1.14.14.16: steroid 21-monooxygenase
This is an abbreviated version!
For detailed information about steroid 21-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.16
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1.14.14.16
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adrenal
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hyperplasia
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cortisol
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virilize
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androgen
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17-hydroxyprogesterone
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glucocorticoid
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children
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acth
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steroidogenic
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testosterone
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adrenocortical
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salt-wasting
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aldosterone
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hirsutism
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nonclassical
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prenatal
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girl
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androstenedione
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genitalia
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steroidogenesis
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mineralocorticoid
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hyperandrogenism
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hydrocortisone
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addison
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puberty
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11-deoxycortisol
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dehydroepiandrosterone
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beta-hydroxysteroid
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11beta-hydroxylase
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adrenarche
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p450scc
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c4a
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endocrinologist
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acth-stimulated
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pseudohermaphroditism
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debrisoquine
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biotechnology
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1'-hydroxylation
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hsd3b2
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incidentalomas
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cyp11b1
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masculinization
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bufuralol
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medicine
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deoxycorticosterone
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adrenocorticotropic
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11-deoxycorticosterone
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17alpha-hydroxylase
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dextromethorphan
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fludrocortisone
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hyperandrogenemia
- 1.14.14.16
- adrenal
- hyperplasia
- cortisol
-
virilize
- androgen
- 17-hydroxyprogesterone
- glucocorticoid
- children
- acth
-
steroidogenic
- testosterone
-
adrenocortical
-
salt-wasting
- aldosterone
- hirsutism
-
nonclassical
-
prenatal
- girl
- androstenedione
- genitalia
- steroidogenesis
-
mineralocorticoid
- hyperandrogenism
- hydrocortisone
- addison
- puberty
- 11-deoxycortisol
- dehydroepiandrosterone
-
beta-hydroxysteroid
-
11beta-hydroxylase
-
adrenarche
- p450scc
- c4a
-
endocrinologist
-
acth-stimulated
- pseudohermaphroditism
- debrisoquine
- biotechnology
-
1'-hydroxylation
- hsd3b2
-
incidentalomas
- cyp11b1
-
masculinization
- bufuralol
- medicine
- deoxycorticosterone
-
adrenocorticotropic
- 11-deoxycorticosterone
- 17alpha-hydroxylase
- dextromethorphan
-
fludrocortisone
-
hyperandrogenemia
Reaction
Synonyms
17alpha-hydroxyprogesterone 21-hydrolase, 21-hydroxylase, 21-hydroxylase cytochrome P-450, 21OH, C3B21RA protein, CYP21, CYP21A2, CYP2D, Cytochrome P-450 specific for steroid C-21 hydroxylation, cytochrome P-450-linked mixed function oxidase system, cytochrome P-450C-21, cytochrome p450 21A2, cytochrome P450 steroid 21-hydroxylase, cytochrome P450c21, EC 1.14.1.8, EC 1.14.99.10, EC 1.99.1.11, P-450(C21), P450 oxidoreductase-21-hydroxylase, P450-C21, P450-C21B, P450c21, Progesterone 21-hydroxylase, Steroid 21-hydroxylase, steroid 21-hydroxylase system, steroid 21-hydroxylation system, steroid cytochrome P450 21-hydroxylase
ECTree
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KM Value
KM Value on EC 1.14.14.16 - steroid 21-monooxygenase
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0.00044
17alpha-hydroxyprogesterone
mutant R409C, pH not specified in the publication, temperature not specified in the publication
0.00046
17alpha-hydroxyprogesterone
mutant T296N, pH not specified in the publication, temperature not specified in the publication
0.00046
17alpha-hydroxyprogesterone
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mutant T296N, pH not specified in the publication, temperature not specified in the publication
0.00135
17alpha-hydroxyprogesterone
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mutant enzyme D322G, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.00138
17alpha-hydroxyprogesterone
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wild type enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.0014
17alpha-hydroxyprogesterone
mutant V282L, pH not specified in the publication, temperature not specified in the publication
0.0015
17alpha-hydroxyprogesterone
wild-type, pH not specified in the publication, temperature not specified in the publication
0.0015
17alpha-hydroxyprogesterone
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wild-type, pH not specified in the publication, temperature not specified in the publication
0.0015
17alpha-hydroxyprogesterone
recombinant enzyme, at pH 7.4 and 37°C
0.0017
17alpha-hydroxyprogesterone
mutant L108R, pH not specified in the publication, temperature not specified in the publication
0.0017
17alpha-hydroxyprogesterone
mutant P31L, pH not specified in the publication, temperature not specified in the publication
0.00181
17alpha-hydroxyprogesterone
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mutant enzyme A265V, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.0024
17alpha-hydroxyprogesterone
mutant W303R, pH not specified in the publication, temperature not specified in the publication
0.0036
17alpha-hydroxyprogesterone
mutant G292C, pH not specified in the publication, temperature not specified in the publication
0.0046
17alpha-hydroxyprogesterone
mutant G292S, pH not specified in the publication, temperature not specified in the publication
0.0049
17alpha-hydroxyprogesterone
mutant I172N, pH not specified in the publication, temperature not specified in the publication
0.0073
17alpha-hydroxyprogesterone
mutant P31Q, pH not specified in the publication, temperature not specified in the publication
0.0108
17alpha-hydroxyprogesterone
37°C, pH 7.4, presence of 0.002% Cymal 5
0.013
17alpha-hydroxyprogesterone
mutant G65E, pH not specified in the publication, temperature not specified in the publication
0.013
17alpha-hydroxyprogesterone
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mutant G65E, pH not specified in the publication, temperature not specified in the publication
0.022
17alpha-hydroxyprogesterone
mutant R357W, pH not specified in the publication, temperature not specified in the publication
0.00021
wild-type, pH not specified in the publication, temperature not specified in the publication
0.00021
progesterone
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wild-type, pH not specified in the publication, temperature not specified in the publication
0.00039
progesterone
mutant R409C, pH not specified in the publication, temperature not specified in the publication
0.00072
progesterone
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mutant enzyme D322G, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.00072
progesterone
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wild type enzyme, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.00079
progesterone
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mutant enzyme A265V, in 50 mM potassium phosphate buffer (pH 7.4), at 37°C
0.0011
progesterone
mutant T296N, pH not specified in the publication, temperature not specified in the publication
0.0011
progesterone
-
mutant T296N, pH not specified in the publication, temperature not specified in the publication
0.0012
progesterone
mutant G292C, pH not specified in the publication, temperature not specified in the publication
0.0012
progesterone
mutant P31L, pH not specified in the publication, temperature not specified in the publication
0.0018
progesterone
mutant I172N, pH not specified in the publication, temperature not specified in the publication
0.0027
progesterone
mutant L108R, pH not specified in the publication, temperature not specified in the publication
0.0038
progesterone
mutant V282L, pH not specified in the publication, temperature not specified in the publication
0.0047
progesterone
mutant G292S, pH not specified in the publication, temperature not specified in the publication
0.0055
progesterone
mutant G65E, pH not specified in the publication, temperature not specified in the publication
0.0055
progesterone
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mutant G65E, pH not specified in the publication, temperature not specified in the publication
0.0096
progesterone
mutant P31Q, pH not specified in the publication, temperature not specified in the publication
0.022
progesterone
mutant R357W, pH not specified in the publication, temperature not specified in the publication
0.11
progesterone
mutant W303R, pH not specified in the publication, temperature not specified in the publication
additional information
reaction kinetic, overview
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additional information
additional information
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calculation of intramolecular and intermolecular kinetic isotope effects for wild-type and mutant enzymes with substrates 21-[2H]-progesterone, 21,21,21-[2H3]-progesterone, and 21,21,21-[2H3]-17-hydroxyprogesterone, overview
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additional information
additional information
Pre-steady-state and steady-state binding kinetics with 17alpha-hydroxyprogesterone, stopped-flow spectroscopic measurements, overview
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additional information
additional information
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Pre-steady-state and steady-state binding kinetics with 17alpha-hydroxyprogesterone, stopped-flow spectroscopic measurements, overview
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