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1.14.13.9: kynurenine 3-monooxygenase

This is an abbreviated version!
For detailed information about kynurenine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.9

Reaction

L-kynurenine
+
NADPH
 +
H+
 +
O2
=
3-hydroxy-L-kynurenine
 +
NADP+
 +
H2O

Synonyms

BcKMO, Bna4, cinnabar, EC 1.14.1.2, EC 1.99.1.5, FAD dependent kynurenine 3-monooxygenase, flavin adenine dinucleotide dependent kynurenine 3-monooxygenase, hKMO, Hs-KMO, K3H, KMO, KYN-OHase, kynurenine 3-hydroxylase, kynurenine 3-monooxygenase, kynurenine hydroxylase, kynurenine monooxygenase, kynurenine-3-monooxygenase, L-kynurenine 3-monooxygenase, L-kynurenine,NADPH2:oxygen oxidoreductase (3-hydroxylating), L-kynurenine-3-hydroxylase, More, NADPH-dependent flavin monooxygenase, oxygenase, kynurenine 3-mono-, pfKMO, Rat-KMO, scKMO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.9 kynurenine 3-monooxygenase

Expression

Expression on EC 1.14.13.9 - kynurenine 3-monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression level is upregulated by pro-inflammatory cytokines
KMO is an interferon-inducible gene. KMO expression was significantly induced by IFN-alpha stimulation in Raw264.7 and WT-J2-BMM cells. The upregulation of KMO expression is abrogated in the IFN-I receptor (IFNAR) deficient (Ifnar-/-)-J2-BMMs. KMO expression is significantly elevated by HSV-1 infection in both dose-dependent and time-dependent in Raw-264.7 cells
KMO is downregulated in autografts and is almost completely silenced in allograft rejection
upregulation of KMO expression is abrogated in the IFN-I receptor (IFNAR) deficient (Ifnar-/-)-J2-BMMs