1.1.1.229: diethyl 2-methyl-3-oxosuccinate reductase

This is an abbreviated version, for detailed information about diethyl 2-methyl-3-oxosuccinate reductase, go to the full flat file.

Reaction

Diethyl (2R,3R)-2-methyl-3-hydroxysuccinate
+
NADP+
=
Diethyl 2-methyl-3-oxosuccinate
+
NADPH
+
H+

Synonyms

diethyl-2-methyl-3-oxosuccinate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.229 diethyl 2-methyl-3-oxosuccinate reductase

Substrates Products

Substrates Products on EC 1.1.1.229 - diethyl 2-methyl-3-oxosuccinate reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
diethyl 2-methyl-3-oxosuccinate + NADPH
diethyl 2-methyl-3-hydroxysuccinate + NADP+
show the reaction diagram
dimethyl 2-methyl-3-oxosuccinate + NADPH
dimethyl 2-methyl-3-hydroxysuccinate + NADP+
show the reaction diagram
-
poor substrate
-
-
?
additional information
?
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-
no aldehydes or several synthetic substrates are reduced, such as: acetaldehyde, formaldehyde, isobutanal, n-pentanal, n-hexanal, n-heptanal, 4-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, benzaldehyde, furfural, 2-methyl-3-oxobutanoic acid benzyl ester, 2-chloro-3-oxobutanoic acid ethyl ester, 3-phenyl-2-oxobutanoic acid methyl ester, 2-methyl-3-oxobutanoic acid ethyl ester, 3-(2'-furyl)-2-methyl-3-oxopropionic acid methyl ester, none of the following alcohols or other substrates is oxidized: methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, benzyl alcohol, glycerin, shikimic acid, 2-deoxy-D-glucose, glucose 6-phosphate, in the presence of NAD+ or NADP+
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-
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