1.1.1.222: (R)-4-hydroxyphenyllactate dehydrogenase

This is an abbreviated version, for detailed information about (R)-4-hydroxyphenyllactate dehydrogenase, go to the full flat file.

Reaction

(R)-3-(4-hydroxyphenyl)lactate
+
NAD(P)+
=
3-(4-hydroxyphenyl)pyruvate
+
NAD(P)H
+
H+

Synonyms

(R)-aromatic lactate dehydrogenase, D-aryllactate D-hydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.222 (R)-4-hydroxyphenyllactate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.222 - (R)-4-hydroxyphenyllactate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-ketoisopentanoate + NAD(P)H
2-hydroxyisopentanoate + NAD(P)+
show the reaction diagram
-
poor substrate
-
-
r
2-oxobutyrate + NAD(P)H + H+
2-hydroxybutyrate + NAD(P)+
show the reaction diagram
-
poor substrate
-
-
r
3-(4-hydroxyphenyl)pyruvate + NAD(P)H
(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+
show the reaction diagram
indolepyruvate + NAD(P)H
indolelactate + NAD(P)+
show the reaction diagram
phenylpyruvate + NAD(P)H
D-phenyllactate + NAD(P)+
show the reaction diagram
-
reduction at 27% the rate of p-hydroxyphenylpyruvate reduction
-
r
pyruvate + NAD(P)H + H+
lactate + NAD(P)+
show the reaction diagram
-
poor substrate
-
-
r
additional information
?
-
-
best substrate for oxidation is p-hydroxyphenyllactate, D-phenyllactate is oxidized at 75% and indolelactate at 52% the rate of p-hydroxyphenyllactate
-
-
-