Reaction catalyzed by 4-hydroxy-6-methylpretetramide 12a-monooxygenase (1.14.13.233)
+
NADPH
+
+
=
+
NADP+
+
H2O
4-hydroxy-6-methylpretetramide
+
NADPH
+
H+
+
O2
=
4-de(dimethylamino)-4-oxoanhydrotetracycline
+
NADP+
+
H2O
