Reaction catalyzed by GDP-mannose 6-dehydrogenase (1.1.1.132)
+
2
NAD+
+
H2O
=
+
2
NADH
+
2
GDP-D-mannose
+
2 NAD+
+
H2O
=
GDP-D-mannuronate
+
2 NADH
+
2 H+
