>P76236|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>P76245|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A0H2ZJS2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain UCBPP-PA14)|Swiss-Prot
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
AAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPASRVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEDAGAESPPAVPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEVVFERADQALYRA
KRAGRDRLEVA
>Q9HT84|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|Swiss-Prot
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>Q8XB92|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7|Swiss-Prot
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>Q8FGJ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)|Swiss-Prot
MGVVRVQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAV
YVSRAGFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ACPLAKLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGR
VGGEEFCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>P76330|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>Q1RAI4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain UTI89 / UPEC)|Swiss-Prot
MGVVRVQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVCASDNA
>Q57N14|diguanylate cyclase|EC 2.7.7.65|Salmonella choleraesuis (strain SC-B67)|Swiss-Prot
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q5PLI4|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A (strain ATCC 9150 / SARB42)|Swiss-Prot
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q8Z5R0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|Swiss-Prot
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>Q8ZNT5|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)|Swiss-Prot
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q32HJ0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|Swiss-Prot
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELAFLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNT
>Q83KM9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|Swiss-Prot
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLARVHTLSEGVRGDF
GSISIALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>Q3Z0N3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|Swiss-Prot
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVCASDNA
>P75908|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>P31129|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0H3AFM6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)|Swiss-Prot
MKNWLCQAVRGEPMIELNRIEELFDNQQFSLHELVLNELGVYVFVKNRRGEYLYANPLTL
KLFETNAQSLLGKTDHDFFHDDQLSDILAADQQVFETRLSVVHEERAIAKSNGLVRIYRA
VKHPILHRVTGEVIGLIGVSTDITDIVELREQLYQLANTDSLTQLCNRRKLWADFRAAFA
RAKRLRQPLSCISIDIDNFKLINDQFGHDKGDEVLCFLAKLFQSVISDHHFCGRVGGEEF
IIVLENTHVETAFHLAEQIRQRFAEHPFFEQNEHIYLCAGVSSLHHGDHDIADIYRRSDQ
ALYKAKRNGRNRCCIYRQSTE
>P0AA90|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>P0AA89|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>Q320T0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>Q73RG3|diguanylate cyclase|EC 2.7.7.65|Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)|Swiss-Prot
MKTTPNEKLLKKALHSCNNKKYADKILHQEKEIFDLKQLLQISKSLNSVLEFDRLIEAIL
YIVMAQLKTLGAAIFTKKSFDDNLFVLNRDHYGFDIIRDAQYSINVDHPLINFLDKSDSG
CTPDEISKNIKTDKIVKDLFSLSPSFFVPLKAKNRMIGFLLLGEKMESSHQFTDYEKNII
ENIASLAAIAINNSQLLEMTTTDIMTHLKLKHYFFTLLMEHLYTINSSGEKKETLSILMI
DIDFFKNINDTYGHAAGDIVLEEVAKIIKSCTRNADTAARYGGEEFIVMLNNTSASAAMA
VAERIRKSVEEKSIMYDGKKINVTISIGVSSYNFDLESAKSIVERADKALYESKQNGRNR
VTLSKNNLPKA
>P0AAP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)|Swiss-Prot
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>P0AAP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>P38097|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>Q8XAZ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7|Swiss-Prot
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>P76147|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>Q8X6V3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7|Swiss-Prot
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>P75801|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>P76237|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>Q8X8Q3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7|Swiss-Prot
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>P77302|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>P46139|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain K12)|Swiss-Prot
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A381HBN1|diguanylate cyclase|EC 2.7.7.65|Capnocytophaga granulosa (strain ATCC 51502 / DSM 11449 / JCM 8566 / LMG 16022 / NCTC 12948 / B0611)|Swiss-Prot
MEKKNYSALFENLQNRSNPEKLQEITTKFFSDNPDVKYNDVLKYITLAMNGVSPEYTNKS
REAGEKVKLHLQDILLDVEYQYQGSVMTNTHIKGYSDIDLLVISDKFYTLDERNIIENLE
VNKFSLSQEKIQKLQQELLGKKYHSATNDLKNNRLLSEQKLSSVYEICDITHPKAIKITN
KSMGRDVDIVIANWYDDAQSVINNRQIEYRGIQIYNKRSNTIENRDFPFLSIQRINKRSS
ETKGRLKKMIRFLKNLKADSDEKIELSSFDINAICYNIEKNKYLHSNKYQLVPILYEQLN
ELVSNSNKINSLKSVDGHEYIFSRNNIDKKESLKMLLQEVKIIYSNLQSYL
>P0DSP2|diguanylate cyclase|EC 2.7.7.65|Elizabethkingia meningoseptica|Swiss-Prot
MNFSEQQLINWSRPVSTTEDLKCQNAITQITAALRAKFGNRVTIFLQGSYRNNTNVRQNS
DVDIVMRYDDAFYPDLQRLSESDKAIYNAQRTYSGYNFDELKADTEEALRNVFTTSVERK
NKCIQVNGNSNRITADVIPCFVLKRFSTLQSVEAEGIKFYSDDNKEIISFPEQHYSNGTE
KTNQTYRLYKRMVRILKVVNYRLIDDGEIADNLVSSFFIECLVYNVPNNQFISGNYTQTL
RNVIVKIYEDMKNNADYTEVNRLFWLFSNRSPRTRQDALGFMQKCWNYLGYQ
>P0DUE2|diguanylate cyclase|EC 2.7.7.65|Flavobacteriaceae sp. genome_bin_11|Swiss-Prot
MQKNYLELIKKVRERSNPDLVQMTKMYSETLSGSKLFENKSIEYSDVSIYIKESMKGVAP
SYTMNSKVAANKVEAHLKKSHGNLVDFERQGSVMTNTHILKENDVDLVQITNKSSEFDHK
GLEKALNNTSVLKTEEILNLKKHKENFSPYQGNQIDDLKYVRLKSELVLSSTYKTVDIEK
ENSIYVKVTEPERDIDVVTATYYKSVDFMKTNDKSRKGIQIYNKKTGKINDVDYPFLSIE
RINVKDIISNRRLKNMIRFLKNIKYDCPHIENKGSIRSFHINAICYNIDVKKYEDLHYLD
LVSILYQELTNIISNKSYRDNIKSVDGCEYIFEFDCAKKLIEIEFLSQELDSIIADLHNQ
SLLVG
>P0DUE3|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium (strain RUG226)|Swiss-Prot
MSSFDYRSRLKELSARYNPEASILVNERMQSEDHYLDTDVVRYVKRSMRAVDDDYTKRTK
DAGEAVKQHLNNELINVTYEYQGSVMTNTHIKGASDIDLLVICEKFEDTEINRVRDCLKT
PYGYSNIQLSRLRNYELSFSLYRGDSREDLSNLRRQIESIMISKYTICDISKAKSVRITN
QHLHRDVDIVTSSWFQSLEYVLDGMPKEEKGIKIYNKNLGFAEGPDFPFLSISRINQKSS
ESNGRLKRMIRFLKNVRTDSQKDIQLTSFDINAICYSIPVADYAYLDYKQLVYLLWSTMY
HLWYDNKLDKLKSVVGDEYVFKGKPNKIEALKALEDDVFKIHQDLN
>A0A150XSC5|diguanylate cyclase|EC 2.7.7.65|Roseivirga ehrenbergii (strain DSM 102268 / JCM 13514 / KCTC 12282 / NCIMB 14502 / KMM 6017)|Swiss-Prot
MLITSNAKTQLEDTLAKMAEAAELDKTRWSRLNTAYEAISKWLSDDPEFFGGVEIEIYPQ
GSVSIGTTTKPYGKTEFDLDVVIHIKLLSSNYDPKTIFNEVVRRLNENETYRKICEPKSR
CVRLNYQGDFHLDVVPGCMVIIYNHELIDITDQKNEIWLRSSPKGYQKWFLDIANRVELT
LLEMTFSAHKVEIEEYAKKKPLQRAVQLIKMRRNIYFDQNPENAPTSIILTTLAAQFYEG
QSSISETFEGIISKLKNHIETLFPNRPFELPNPVNPSENLADIWVDKPELYKHFISFINN
LHNEWQDLKKAHGIEEEAILMKGMFGNDPYIKAMEARAETVNQKRGNGLGILATGVMVDR
AVEKSLPVMPNTFYGD
>Q9KKZ4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)|Swiss-Prot
MMTTEDFKKSTANLKKVVPLMMKHHVAATPVNYALWYTYVDQAIPQLNAEMDSVLKNFGL
CPPASGEHLYQQYIATKAETNINQLRANVEVLLGEISSSMSDTLSDTSSFANVIDKSFKD
LERVEQDNLSIEEVMTVIRRLVSDSKDIRHSTNFLNNQLNAATLEISRLKEQLAKVQKDA
LFDSLSGLYNRRAFDGDMFTLIHAGQQVSLIMLDIDHFKALNDNYGHLFGDQIIRAIAKR
LQSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVRRSIEKLTVKDRRSGQSVGSIT
ASFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL
>Q0T466|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENGEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>Q83KV7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>Q3Z1N3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|Swiss-Prot
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVHSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>Q9A5I5|diguanylate cyclase|EC 2.7.7.65|Caulobacter vibrioides (strain ATCC 19089 / CB15)|Swiss-Prot
MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMD
GFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLT
RFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPV
IESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRM
VKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNR
RYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRA
IDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSAT
AGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA
>B8GZM2|diguanylate cyclase|EC 2.7.7.65|Caulobacter vibrioides (strain NA1000 / CB15N)|Swiss-Prot
MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMD
GFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLT
RFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPV
IESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRM
VKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNR
RYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRA
IDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSAT
AGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA
>A0A655X316|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIRNSDHLRSLGIAPNDVVAFSYPLPQTNALLGLDYRTVPQQWQSIKKAREIKQTFVSGP
VDLVQGGRALVIREPIFYDPPKDTRYWGVLSVVMDWDSLLSATSIYSFGEHFQVAIRGLD
SRGSEGDVFFGEPRVFEHAFAQENVYFPYGSWRIAVAEKQDLLQQLSWYTRNAVRLLGYS
VLLVLMAGFGVIMRLYQVAEERALHDPLTHLPNRRYFIYTIEHYFENAKRSHSEGNFALL
NIDIDRFKSINDSHGHSAGDKVLVACAERIKSSLRVSDLVARIGGDEFLVLIPRIHREQD
VLKVSDNILKRISETPIVYDDKLIHVRVSIGYALYDQSFATPDEMFKLADERMYTAKRRQ
NPLYRF
>A0A1X1PL54|diguanylate cyclase|EC 2.7.7.65|Burkholderia puraquae|TrEMBL
MTRHAPPVALSRVPRPTLQSVLRRAHLRLAFVAVAMAAVSLIVVAVIALRAYAGNNLNLL
ARSLGYTVEAALVFGDRVAAAEAIGMIAGDEDVAQVVVTDSKDQPFATWQLPAGSGIARL
ERGVADLALPGPVTAPVVHDGIVVGHVVVRGRGHQFFGFLLGGVGGILGCLAVSVIGAYI
SSKRLLRNIVSPLRALAGVAHAVRRERAFAQRVEPAAIAELNQLGDDFNALLDEFEDWQN
TLRDENASLEHKATHDALTGLPNRMQFESRLALALGEAAATGRRVAILYLDCDRFKEIND
CLGHDAGDAVLIGIASRLRKQVREADLVARLGGDEFAVMLPAVHEADSVCRIADEILSGM
VLSIELSDGRVVATMMSAGVALYPDHASDARGLLRAADAAMYRAKRARPGSWQLAEGVAG
AA
>N0GU94|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIKMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPDFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRTLKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGTVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A0I2WLD4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSPEQRRAICEAFESANNTH
GLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKF
HYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQR
TKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDI
IINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHF
RLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLG
HQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIA
PQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A2C6DK50|diguanylate cyclase|EC 2.7.7.65|Budvicia aquatica|TrEMBL
MDSHLIYILIESSIEASCVIYTFLSIPYIYFISGKLDLQKSTIAMGIIAGVLVGYLVNFD
GEQSTRLYGIIVSPIIVSYFVFGKRALILGCLTAILLTVGHSLSFSVFSFIFFTIMIVLS
FFRQIRFSYLIIAMLMAQLINLYVNYNVILLKVTPTELTTRMTLSFLSLFFLHVTFNFLF
SLSGRVNLLQHQSETDALTQFINKRGIDINLKLIEISKTHCCIAFLDVDFFKKVNDTYGH
PSGDIVLSNIAKIIKGNIRSNDFAGRYGGEEFLVILYNDNLNKSKEVLDQIRIMIEGNTF
YSTDSRPIKLTLSGGVAKYNPSGDKSINTVLQYADKALYTAKSQGRNNVVLYQDE
>A0A1C5W481|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKIKKEINLFAGMFTAEEIYRYGDIILLLGHIIYLVLFYRFGVYQMVYYNYFSVAFYAVM
YFLLHFKKIGKISFTYLVLGEIIVHACMGAYYIGWSAGFTQIMLCIIPIPFFIVQNRKAI
PYILSSFDVVVFIVMRIIVTNRVAPYSFDTNRENILYIYNTLCSFIIIIYVSSIYIFTNE
HNKREAKAQNEKLQKLATIDPLTQLFNRRAMMDFIKKIESNSRRTNSVYSMCLGDIDDFK
HVNDTYGHEVGDKVLRAVSDVIAGNVPSEGYVCRWGGEEILFVVPNTDTESCEKIAKSIC
QKIHECTFKENSRSFNISMTFGVYSVTPNENYDEGISKVDKLLYKGKNQGKNCVVSK
>A0A3V2FQI3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Braenderup|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2X2WLA1|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MKLHHKALRLFISASVIVLTSSFLAYELIASDRAMNAYMGYIIEKADSSFLYDKYQNQSI
AAHLMRTFTEPKTPPSDEQQYALCRGFETDSNTHGINLTTHNNPSLHGTLQTAEANCAIV
ADDAPLLFAFDQAVAANRNQKDYGKGLGTVEDKFHYYLDIKKRYVYFYNLIDSRQFFMHH
WSFLRKGTLGINRNDIDGQFTGRTVLSSIYQDDLTEKNVMSFLTPVYLHGKLKGIVMVDI
NQDNLKNIFYTQDRPLVWRYLDATLFDLNSEKKIIVHQSENNLFNYVNYVHDLPGGIRVT
LSLDILYFIVSSWKLFAFYLLVTATLLNMVRMHFRLYHNVNRENISDAMTGLYNRKILTP
QLEQRLQRLVNTGTSVTFIAIDLDRLKVINDTQGHQEGDRTITLLAKAIEASVRKTDYAI
RLGGDEFCVILIDSVVPATTLPERIANKLRIIAPDKVISFSAGLYHMQPEDTIQDAYKAS
DEQLYLNKQQNHARL
>A0A8E6XAN0|diguanylate cyclase|EC 2.7.7.65|Salmonella pullorum|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A607PF43|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHRRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A069AVE6|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAIFDEFNLSKEIESDLVN
CWSKIVYPDDVQIWKDDIQELLHGKKGEHNLEYRLINKYKEIVWISCRGKVYVSDDPKTI
FLVGRIKNIGEKNKFDSITGTWNREQFEHRMNYLIKEKIYKNGAMFIMDIDNFKNINEKY
GHSYGDKVLRAIATEVLEYLPKDVRLYRLDGDEFAFFYPMCTKETIEKIYEKIQMYTNTQ
HEIESNKYYCTVTAGVAMYPEDGDNYLDLFKHADIALDIAKISGKNRIKFFSQELYENKL
KVISMQQKLRECVENNFNDFELFFQPQVNAVTKEVIGAEVLLRWHSSTYGEVSPVEFIPI
LEQSNLIIPVGKWIIKEAVKQCKEWHKINPDFKISVNVSYIQLKEDFFRDFIVECLVEYQ
LRPEFLILELTENCWIPDINLLNDKFISLKGIGVYIAIDDFGTGYSSLNYLKELSVNIIK
IERSFVKNITYNSYEYTFLEYIIKLAHIINLKVCVEGIESYEEYDIVKSLGVDIIQGFLF
GRPVSASEFYKFQLSK
>A0A5I2AE40|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durham|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A031WLI8|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MKINKKFNRVDMQVSILTAIIVIISSSCVYFFNYTLTYKSMIYSLSERSKHIYEYVERNI
DKNTFTEINSKEDQSKKSYKSSKILLESVKNTTGVMYLYTAKKTKDGSLVYVVDGLNSSR
SDFRNAGDLIEKEIWGDLNKALDNHILLPKKIKSTSWGYIFISYFPIHNDVGKVVGVIGI
EFEAKHQYNTFKFISIVTPIIALLTCLISALIAVILFKRISNPTYTDFANTDYLTGLKNR
NAFEIDMNNLNNSNLKNLISIISIDLDGLKKINDKFGHQTGDLYIKQASKIIQYVINKKY
IVYRIGGDEYIIILKNLSHKEINNIINNINLKIVEENSTNELKLSMSIGYAIFDEKVDVS
LFDTYRRADSQMYDNKRKINKQYQ
>A0A3Z1TWA8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Haifa|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMHVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3W0FGL0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Litchfield|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5J1URL9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mississippi|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0P6Z0B4|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MTLYKQLVVGMVAVFILLMTSVFMIEFNTTRGYLEEQQRSEVSNTINTVGLALAPYLEEK
DKVAVESVINALFDGSSYSVVRLIFLDTGDDILRSYPVKPTGVPEWFTNLNLFEPVHDRR
VITSGWMQLAEVEIVSHPGPAYDQLWQAFIRLLSIFGTIFLLGLVSISWILKRALRPLSL
IITKMDQIAKNQFGEPLARPKTKDLTLVVDGINHMSTQVELAFKNQAKEAQKLRERAYID
PVSQLGNRAYYMSQLTQWLEESSLGGLAVLKAEFISEEYDEKGYQEGDALVHQLAEQLQA
SISSPDITIARISSDEFGFIMPNIDESELKLVAGSIVNCIQNLGSDPTGTANPHIALGVT
YSNTRKTSTEIMSLVDNALSSAKANRELTYGYVTADDHGAVMGKQQWRMLVEEAIINDLV
TFRLQAANNSFGKTYHQEVFSAIEKEGVRYGANQYLYALEQLEMSHILDQYVIEKMIEKL
NAKEVTSPVAINISPSSISQPSFIRWIGKTLEHNASIAHLLHFEIPENCFINVPHYTALL
CNTIRNAESVFGVDNYGRNFQSLDYINEYRPSYVKLDYLFTHNLDDEKQKFTLTSISRTA
HNLGITTIASRIETQTQLDILSDNYVEVFQGFIVDK
>A0A0D6ISP2|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MDTGLSFSLPKWRLTRWLTHSGQDTPADIRAALIASLFGTLPIFAGGVINTLMISGVVAW
RRPEPLYISWLILEILLAVVRVTVLRSALRNAARGGSTHTDIYIVLALLWAFSVGYGVFV
TFLNHDWLAATLAGVSCGAMAGGICFRNYGAPRLVAAMIFLSLGPMCLGALFAGEYVTAI
VFIQIPFYLVSMSIASQRLRRILVSTMLAERENERRASQDALTGLANRAGLEAALERICT
SAREHDSAAALFYMDMDDFKIINDTHGHAAGDQVLKTIAQRMRAMLRVDDVAARIGGDEF
IVLATGIDATAALRLGNHLLHDASQPIVLADGTRVSVGLSIGISIISGANRKAQAVLDSA
DAALYRAKARGGRRCSVAGLPDAEDALRPGDAAAAA
>A0A1C3IMY5|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MASSFVTSSMFRFCFPLFLLAILFAGMNNVILVTDSNLGFASNLPYILLSVAVLLCHTFR
QGRMAMVSLTMLVAYLIIQVRLQTPLNTGTTLLELSLLAALVPVTCLLVYAFPDNGVNSK
SMLLYAIVLVLFMVWAQLIVSHFHAGGFESWSEGLLFIVRDFSKLPFVLVLYSLCLLGLT
AILVLVYNRSIDVVVYSTILLSSCTFIFFDVQYISSTMFSLSGTLIIVYVMSASHDMAFN
DQLTNIPGRHALEVDMKHLGRKYSMAMVDIDHFKTFNDTYGHDIGDDVLKLVARILRETT
GGAKAYRYGGEEFTIIFKGKYKEQAKEHLQVLISEIQNYDMTIRNSHERPDDHEVGIKNR
GQNGKPSEMVNVTVSIGLSDSTTTKHPEEVLKLADKALYKAKETGRNKLCVNS
>A0A174TSW1|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKQDWAALKEENEILSKLASHDWLTSIYNRGATETKINQLLAEKKTGVLFVLDVDQFKQI
NDRYGHITGDSVLQEVVRILSLMTFKHDILGRVGGDEFVIYMPLAQNQNFVDERCRQIRS
RLLGIQMTNPLINGISVTVCGSLYQPGDDYKSLFDRADQLLLSEKRKKNKKPFLTAAEER
RSAARKGIEIDMALIRTELSEQELTTGAYCQDYDTFKSIYRFVERRLRRSGESAYIILFT
LTDKNGDFPKLLTRENQMDTLKSVTQYSLRLGDVFTQYSSCQYLVMVSDVDGQNAELIAR
RISEAFYAETADIEDKLLLHHCYPLKPAGTS
>A0A447KM64|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MNARSYQELLTSKHRLSLFLFLLMNAASSIFTLLMPFKNTPVITLPLMGIPLFCLAAMAY
TVFCPRQYVRKLHVFAAILGVLWAAHIYLKSRYCVPDSQNFLLISLFSMFFISAIALTDN
FVAFCLHSVPSAITILLLDGMNNTVRIVFTSVLPIIAFSIHHLMLKRSEAFTQALVANLY
DERDKLSDLSMLDPLTGLYNRRGLENKLNQLLAPTAGRHFVVLLDIDRFKAYNDNYGHTM
GDQALVQVAAAIRDAVRSRDIVVRYGGEEFLVLLTNVSEAYAAQLAERVRQRVLGLQIPH
RFNQLATTTVTLSAGISALDQLDVKSAIRAADAALYQAKGNGRNTIQLAENAQSAPLA
>A0A702JCH4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAVG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A315G7P5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A729QQG9|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSELRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2T6X790|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A3V4R6V9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X5BIH9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3Z4EUB9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0C7KEQ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAMMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
AEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A5D3JEQ7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A5I0NZN4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Brandenburg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A132HJD5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus metallidurans|TrEMBL
MTPETAATRSTLPIPVPAARWGLLLAAVGYFALATAGIWLGRQPGTGAMLWMGNAFGLGL
LLHRPRQETPALLASMLAADVVANLLADHTAGVALLLAGANLLEIGGMAMLLRLMSGSGT
LARTGPLATFALKIGVAATLGPAISGVPGAAVLATAYGTQFPRVWWAWWNAGAIGMVMLL
PLMVSISRERVQAALRRPMLLRLIALFVLCMAIGTGAIVAGHEPFVVMSLPLVIVALASN
PFATALLTLVSALALEGIAHLGGMQFLASRATPLSGALILVFPICIAFMTEQNRNGRAEL
RSSERRFRQALEHSAIGMALVGLDGKWQLVNRAMVDLLGYSAEELRDLPFQVMTHPEDLA
ADLSQLDRLLAGEIDAYRLEKRYRHKQGHYLWALLAVSLVRDEHSGEPRHFIAQIEDIHT
RKLAQEQLEAQTRRTQLAVEAGGVGIWEWDFNTAAITWDARMHALHGADMELGPPSLAEW
IAKIHPEDVSRVSSEMRQAIRGARRFDTEYRIVRPAGETRHVRAMAMISRHEDGTAHSLV
GTNWDITEQRTLTRALFEEKERLQITLRSIGDAVICTDRVMRVTFMNPIAEQLTGWSLDA
AMGQPLDQVFRIVDEITGLTIPSPVEQCLETLRPAYLQEGAVLQSLTGERHDVQDSAAPV
LTNDGAVLGAVLVFQDITSSRAMQRELAHSATHDALTGLPNRAWFEKRLREACEQARLHG
HRTALCFIDLDRFKIVNDTAGHGAGDVLLRELGYVIRHHVRPDDLLARLGGDEFALLLKD
CSIDHAEQVCQKVINAIRERRFPWEGRVYDVGASIGIAAIDADAPPVSELMSRADVACYA
AKAAGRNRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLYVQEIQPLQPETEHARH
VEVLVRMVDEQGTLIMPGAFIPAAERYDLMGHVDRWVIRNVLHQFGERLARVADLVVSIN
LSANSLGEPFLLPFLHTTLEDSMLPAERLLLEITETALIHNMTAASRLLKEMRHAGCTVA
LDDFGSGLSSFAYLKQFPVDYLKIDGSFIRNLADNVVDREIVSSINDIGHRLGVRTVAEW
VEDEATLRVLRAIGVDYAQGYAIGRPMPIEIFLEICENADT
>A0A3V7IKU6|diguanylate cyclase|EC 2.7.7.65|Salmonella rubislaw|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X3FAY3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLMEVASRL
MTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNLHNGHSATLSLSV
GYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A066RE33|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2V2LZD0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAATNSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQTAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0Q2YVL3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8F6W9C9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1X9TMG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMASNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAK
>A0A232N463|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A1Q6BFX1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
QGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENRWHDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEESLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>C3SCD9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLPLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSAARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYGVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A376YAU2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQ
KVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A376WVB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0K4LFC8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDIEARLQHIMFARNSQ
KMHIPENFSVCWDYSLCKRAIDENCFFSDDVPDRWGDCIAARNLGITTFLSTPVHLPDGS
FYGTLCAASSEKRPWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDALT
GLPNRRAIFDNLTTLFSLARHLKCKAIIAFIDLDNFKLINDRFGHNAGDLFLIQVGERLN
TLHQNGEIIGRLGGDEFLVVSLADENANIPSLRGRIEQQIRGEYRLGDINLFYPGASLGI
VEVDPETTDADSALHAADVAMYQEKKHKEKTPFVAHSALHS
>A0A377LDG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADYNMYQAKHQRAEKLVR
>A0A765T5T0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLSLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAH
PGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A400L8M3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVFLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A4V6YJ94|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7B8D7J6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQDNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFNPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQACHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7A9NAA8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLFSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLASYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A377LHQ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQDQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A730GVN7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A165JXF2|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MKLRDNFKRKTIDRLDYRYHLLLLIVPICLFVLLFIFNAPTEGWTILPLLFVCIIYIFAY
SLIYYLHQGRLTRLWEHLEQVVTINDAIYELAHLSSHYKNEHAFLDALLNKAVYVINGAE
MGSIIKVNEANNKLHFESVVGLDLAKLRQLDFTLEQTFEYRLTKGRCDQVVVINDMKNIN
AASTLTEDDQRVLLTVSKQPIRSTLSSPIRIDGKLYGMLNLDSSSLGAFSDYDRNLVSIL
THEASNAIALYQKSQQITKLANFDPLTGLYNRKNFEDELHHWQHKPHLGSFLIIIDMDNL
KAINDAYGHQTGDVAIKRTATAILTYWQNKGIISRFGGDEFVALCHGPLTQIEQDLDNMR
KTLNQGSELSLAFSFGIAPFETDWYQSFKTADHAMYEQKRAKKKAIKALETFAVKAQ
>A0A5C5HBB9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6S4YBY2|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MSDESKKYISVIFKEWLPLYDGLKPEVKAILKNIAAEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKEQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDHQTGLATIHYAVMAINMAIEMMCHAYTLSHYRATKNEEAYRLYSLM
DNVPMEYGKQQASLSGWENSAIFNIVSENKNDINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLITQVDNLIIGWKSSDSGAEYKNTQTLLQSIHILCQKISSQLGVIFSSLSQMQN
GKDSLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDNWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSAGFAVHTGHPDYNRLLRDADSALYVAKRSGRDCVKMHQVEQDPQH
>A0A5H7K3J1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cubana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5H7K1V8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cubana|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A746ZFT0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAAIMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A633VXT9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDSRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NSQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Z3MRV6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLVSCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379SCF9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A624MAK9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A757ZUL7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>I4ELX5|diguanylate cyclase|EC 2.7.7.65|Nitrolancea hollandica Lb|TrEMBL
MIVVDSAIWALPLLIIPAAVSYRAVAHRLRQEPEVTGKAGAERPGSHFQRLLDSASDGVF
SIDQDGRCTFINRAAAELLGYAPEDLLGQVIHQIIHHSRKDGTSYPGDSCPDFTALKRGR
GMRVDDEILWRRDGAMLHVLYAVSPIVDSGNITGAVVVFSDSSERQALQERLRHQALHDP
LTGLPNRILFMHRLDQRLANPEESSAALAVLFLDLDGFKFINDALGHEAGDQVLVVVAER
LKACVREGDTVARFGGDEFTILLDSLAATSDATDIASRIVEQLQEPITVNQYQISLTLSV
GVVLSLSPRDLSGDLLRHADAAMYAAKADGKARFTVFDSRGQVSARDRSYSACRKGPSRA
NTDEQGDHDPADQAVRFVRVGKHGVLRLPVWIDSDSWKLNALDESPPLDHQFEDDGLVDA
G
>A0A8E7U808|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVSHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G1HVD2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MIKASLRSHLTLWFAGLSLLTLVSVGFYVGHIATEQMKQASGNALLSTARSAAELLGAQL
HERQLEVSLLSRAPLFKHGDLGDPDILSSMELRSQSRAEYAWMGVADANGRVRQAVNGLL
VNQSVKERPWFQAGLRGAYTGDPHEAVLLAKLLPGTASGEPLRFIDFAAPIRNAEGQVIG
VLGAHAHWSWATRIVDAAVLRKDMTPEVEALIVDHDGKVLYPEALMGQRVANMPVARENH
SDTAGWSVGDGYLTSVVAVPTPSSTDLTWYIAVRQPLDIALQPARILFYKLLVLGVIAAI
VFALVAYYLALYLSRPIEQLAKSAKRVQNQQPGVTFPRDHSVREIAQLGQSLQGMTESLL
GKERELQEANASLEATVAQRTAALTQANADLLKLATHDALTGVYNRRRFDEKLNECNLLF
QRTGRPFALLFIDADHFKQINDTHGHAIGDEVLHQLARLIQGNTRATDFVARYGGEEFAV
LLPEVEEPESPEVVAEKIRAAIAAAIFATAGHVTVSIGIGLAEISDSNTTALIKRADQQL
YQAKWSGRNRVAPQARVTERH
>A0A853SLN3|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MAGRQNRASWRKAHWLLVLACLLPPASHAQVSKLEQHIAAVREDGRFVPARALQRLEEVE
SQARNAPLLVRAEFLTQLSTVRMRLGQNDIAMRLAEELIAYARQNKSDVALAKGILCKAY
VTFAMNERRASHLLAFEAERIANRTDDLPVRVQATISAGQSWAEEGNFPFALAKLQAAVD
LARQSNSPSSLAAALNALTLLYTQMREYDKGFEVLDELLAVSGTLASPGRMAQAKNTEYG
LALDAQQPQRGQRALLAALALERQLGARGMVAVTLVNLSDSYLKEGDYTRALRFANEAIT
AARLVNNEQVEATARLNIGQALIGQGRLQEGKQSVATGLAYYERTANQPEMQAVMLEYGM
ALEKAGDLRGAVTAYHRERGISNQLFEKQRQKAVYELQEKYEAEKKQRQIELLSRENQIK
STEIDNRRLQQRVWWLLALVLAMASVIVGLLYRKVRHANVQLKVKNQELKRQSSRDPLTA
LYNRRHFQEFMRSHAGKPQPSYGGADVVGALFLLDVDHFKHINDAYGHAAGDLVLTTIAE
TLHEVLRETDMIVRWGGEEFLAFLPAVARDGLDDIARRILNGMAAQSIHYQGQAIKVHVS
VGFAPYPLAPLGRPLTWERSVNLIDMALYLAKAHGRNRAYGLRGFQQVERTTLEAVEQDL
ERAWRDGFVDLSVVLGSADGVDKTETVGQKRPGGQASDGVAAAAIT
>G4SU30|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MVEDDPGDANLVRQALRASRDVHFEIIWSTNLTEAKRQLQDGSLDVVLLDLTLPDSSGLD
TVDAVRQAAGTLPLIVLTGNDDSQFALRTLDCGAQDYLVKGRFETDGLVRAIRYAVSRGR
LEQRLAETGMHLRTLINALPDIVCFKDGEGRWLEANDFDLKLFGLEHVDYRGKKDSELAV
YQDFYKESFLACEASDEKAWQAGVITRVEEDIPRPDGSSRTFEIIKIPLFHDDGRRKGLV
VVGRDIDERKQAEARHRLSTRVFETAGEAIMVTDADANIIAVNPAFTRITGYTEAEVQGK
NPRLLNSGRYSKSFWAAMWRALQNKGEWAGEIWNRRKNGEMFLEWETISAVRDERGNVTQ
YIAVFADLSEIRRAQEAAEKLAWRDPLTGLGNRALFLKELEQTLIAASREGRFAGVLLLN
LDRFKDINEARGLAIGDELLKTVATRLLDALSDDDLLARLDSDEFAVLLTRQAPTQEAFG
REALALAEKLRAELRRGFEVEGELMHLDAAVGIALCSEGNGETAIDILRQADMAMHRAKT
EGGGRVVFFETTMGDAVKERFKLEGELRTAIAEGQLKLYLQPQVDSDGIQVGAESLVRWQ
HPERGLIMPGVFIPLAEATDLIVALDRWMLGSVCRILAELDGEGRSIRLSVNISPRHFER
SDFVGEIKRQLMLSGADPTHLVLEVTEGLMIGNLEDVVAKMTILSTMGIHFSMDDFGTGY
SSLAYLKRLPIHEIKIDKSFIQDAPTDPNDAALVETILAVAQHLSLQVVAEGVETQAQSD
FLKARGRVIYQGYLYGKPEPAESWLQRLRDQ
>A0A8G1HL46|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MGKTGGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLNPASWVWGLMVVNGVLWPHVAYQ
WARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQILGVGVGLLVFTPAFVAQTSPLQLYACLPLLSLYPLALGWICFQQATTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQQQGGAIALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVLLPDLPLDSAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFDPSHTDATLWLNDADQALYQAKTTGRNRVIYRIDGKPHHELLDPV
>A0A7T4B300|diguanylate cyclase|EC 2.7.7.65|Achromobacter deleyi|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHKGMKGWLKGLLCVREQGDIAALMAVQKKVGEVHARVH
IPIHLVMAGARILKNEIALRLRASDLDGVAASVATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPGLLQADLAGLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAVNDQHGH
AGGDQILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALLVAEKLGAEIRRHAF
TIPEVGTLRITASIGVAAFDGHPDYAYLIDRADKALYQAKQLGRDRSVAA
>A0A853HDY5|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MDLQQIDLSLKELNQAVKLHYEWSGKFLELVLLGSEPDNTFIHPQSHLYCRFHHWVVSCD
NIPSRYARFIGNISETHKTMHDYARTLIQSIANKRVDSDELYAYHDAQQQFVASVDGYRQ
QLISLRNRHDTLTGLPLRQLMYEDFAFLHAHAREQTLWLLIIDIDRFKKVNDTYGHNAGD
DVLREVAQRLKTEARSGERVYRFGGEEFIVLLDAHTSQAAREAGLRFCGSPGRRPLRLNG
ETLTVTVTGGLTCVRPDETLHEAIGRADDAMYFGKNNGRNRCILTLDGLMRETLK
>A0A8G2RFU3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRAREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2D1QEN7|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MSSPPAFFHCSGRHIGPLLMPLLLIILACLPARVAAQDPIVLQLKWHHQFQFAGYYAAIA
QGYYRDAGLDVRLREAGPGTDVVDEVVSGRAHYGVGSSDLLLDRQRGQPVVVLATPFQHS
PLVLLARAEIDNVHDLVGRRLMLEYHSEELIAYLQHEGVALGLLHRQPHTLSADALIRGE
VDAMSAYNTDETYTLQRSGVPYQTFTPRSAGIDFYGDNLFTSERELRDHGARVRAFREAS
LKGWRYAMLHPEEVVAWILTQYPATNNPALDRNKLLFEAKQMQPLIRADLVEMGYMYPGR
WQHIAQTYMDLGLLTAMPDLDSFLYSQQEERAHQQQLMIYQGIAIGLLVTAFLLILLMIF
LRLNRRLREESKARHQLSQEIADNERHFRFITENSADVIWTMDIQSGRFTYLSPSVQHLR
GFTVEEVLAQTGEELMTAESADRIARQMKESLATWAAGDHINTKRVTLVDQPHKDGRLIH
TEVVTTLHADKDGNPVSVLGVTRDISDRKASEEMMRQLAFYDPLTHLPNRRLLQDRLQHS
LQQADGKPLALLFIDLDHFKPVNDQHGHEAGDWLLATVAKRMLHCVREGDTVARIGGDEF
MVLLPEITGEAGAIAIAEAIHQSLNQTFAMTDALHFHISSCIGVALYPQHGTTQKQLMNH
GDQAMYQAKEAGRNRIQLFTPQMAGGITREVANQMQLGWKQSHDCGHPQIDDDHRQLFAL
ANQLLNGVLTMEEDTDQFHQNFEALLALAASHFNNEEAILAKLEYAELDTHRQEHQKLLR
RANSLYQAARTGELTNLALLDFVLQDLVLGHMVKQDRRYFPLLKASMQEETLLSPDGPLT
SPPPGLVKH
>A0A2T3QLM0|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MFSLSMLRNASIRLLIPLLIAGLLIFIYPQLYVLLTPFQASLQVLPFVVLALVIILSQPF
NQGRIGIIAILMLESYFLILNCLQQPLASGDTRLIYILLSALLPLNLLLLHIVPEKRFLS
RCGFAMLIFNMVQIALSVAIVWLYDGSALSDWWYAVFYSYNNISPLPIILLLLNIALICS
SASAILKRNQRTDQAIYICLLFSFITLAWFDNPFISSMSYSCAAILLLSSLITSTHELVY
IDPLTTIPGRRALDTELKYLGRTYTLAMMDVDNFKDFNDLYGHETGDEVLRLVAQISQKI
SGVGKVFRYGGEEFTLLFKGKNINEVQSQLEYVREEIACYDLVLRDHDNRPLSALQGKLK
RQHNDLEPNAVHITVSIGAADSYSAPTPNDVLNLADIALYNAKDDGRNQVSVDYTLRKTK
KKKRTPKKKKATK
>A0A5S9P4C7|diguanylate cyclase|EC 2.7.7.65|BD1-7 clade bacterium|TrEMBL
MTLVDKRILRVTQALVLAALAPIGWMLLQYLMGIDVYATIREDSLVYWYMFVGSALAFVS
FGFYVGTNEMHLESLAITDEATELHNERFFKQRLPEEAARAGRLRQHFALIYLSLDHFSD
INSLYGRSVGNSALKLIANAISGVARKDEIIARVGEAEFVILLTDCSQGQANIAAARFLK
CVSDVEFQVEKGKQISITASIGLISSETNNSDEWQLYTFAETAMYRARRDGRNQVAAYNI
D
>A0A485GLC6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRHPLALIAVLFLLLAGATSGAASGPPGGAWLNGSLALLEDPDGSLQVDDLEQPERAERF
VAAQGRTSVGLSRSVWWLRLDLPPREAVPGGWWLEVASASLLDLRLYLPDGQGGYRERRS
GDAVPFAEGRDHAYRHPLFRLPADDGPLRVYLRSHDPGGNAFPLRLWSHDELLEYRSQGN
LLFGMAYGLILALLLYNLFLFSSLRDRACFWYVLTGASALLLTLSISGHGFEYFWPEHAL
PWWLNRLTLLAFWGICVIRFSQNLLQSRQHARRAHHLLNACCMLFLVCLALNAGGWRWQA
GGMLAATLLANLPIAIGLALQRWRQGSATARLYLLGFGLVLASVSLELMRATALVQPTSA
NATVFPLALTLEALLFSLALASRIQNLKQERAQALEQADQEKNARLALLHSAQRDLARAV
EVRTNELSEANRLLQMREAQLQYAALHDPLTGLGNRRQLLEFAERALEDARRHGDSMALL
LIDLDHFKPINDTHGHDAGDFVLQSVAQRLRQCVRADDCVARLGGDEFAVFIGGSNAEQH
AREIAERLLRELAKPVEFAKQWLVITPSIGVALFPGDALQFGKLYKAADQALYRVKGAGR
AGYAMAADAQRETAPALPWPSALAPDRSS
>A0A6W0P387|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rubislaw str. ATCC 10717|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKDLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2X4YQS6|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MNLAVRNGTPLSCLMIDIDHFKAINDNYGHEAGDLVIKNVAAIIQRAVRDIGMAFRYGGE
EFLVLLGGTHEEAAMACATEIYHSVQRLTLRYGLAEIGQINVSIGIASYPQHTHSDSLLR
AADAALYRAKELGRSRIVSFGMLKAD
>A0A564JB48|diguanylate cyclase|EC 2.7.7.65|Klebsiella huaxiensis|TrEMBL
MDKPMWMKKLRRVLSPGYVVNLCFFIVFCFSTLLIWREVKILEEAYVANQRNNLENVTHE
LDGLLQFNIDRMIFFRNGMQSALGTPLDFAVLRKAEQDYLEKRHEPIWSVEIRNRRTLPV
YGVADAFVDSDDLLSRDIPFSGNELMASLELGYLLRLANNNQGLTERMLYVSRSGFFITT
KPPKNSTQALGLYSRAISASWFIQQTQRNNPARGIVWQTFSGDEPQREAQVVTASIPLDY
QRYWLGVLAMDFSVREMRNFLVNAVKNGQESEYQLYDNRLNLIASSASDNVLTLLSPQEQ
EQLRSAFSHGNQGGIRLLTRYISWEKLRNFDGVLLRIHSLKDGVRDDFGRITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWRAWHDALTRLLNRGALFERASEATTLSERLK
RPIAVIQLDLDYFKGVNDRHGHQAGDRVLSLVGSTIASHIREDDLAGRVGGEEFCIVMPN
TTLHEATAIAERIRVRINGREILLRNRTSLRVSASFGVSSSDNSNEFNFESLQSIADHRL
YLAKQNGRNQVCAEG
>A0A1A6AVP3|diguanylate cyclase|EC 2.7.7.65|Clostridium ragsdalei P11|TrEMBL
MDYENMDKKMLIKILRQKDDMLKKLCLEKEKLNYYANTDAMTGVLNRRSGLKLLDKGLNL
SKINDRDMVVCFIDIDRLKIINDTFGHEEGDKLLINTARILKESIRKTDFVIRMGGDEFL
VVFPETTMKEINKIWHRIYVKIEEINKNSSKYNLSLSCGFYEYKKEGQSEMTASDLIKNA
DFKMYNKKLNKKEKFDDKCINNIN
>A0A7W6FLG3|diguanylate cyclase|EC 2.7.7.65|Rhizobium fabae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYEALAICERHQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDNLTRAGEGRADENAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGSD
EMVVRALDLGVNDYIVRPVDPNELVARSLTQIRRKRYNDRLRNSVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEVAATVAERLRAAVESTSFALKHSGQALSVTASFGI
ASRIASVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A064EB61|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii MGH 56|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADYSSSLLSDAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATAMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
NEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKSV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMASSATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A7Y8GPC6|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp. SAM-B|TrEMBL
MHNVPNLDDASQPLALAWSQTLAQTPAAAATLLASLSAESPPELAHHFYDVLLEDPRAGR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQAEESATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTRTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATDVQAEVIAENLRKHIAQSPVQLASGQALSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDRVVLASDDLPDAPGRQALQRG
>A0A176XXA9|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSSGVPPAAATANAANGQACYLSASNAQAWEAVYQSVDANTRGQVAALVSDHAAQLV
DAFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVREQGDIDVLMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIAQRLRAGGLEGQAASVATQYVCNLFDLAIEQMSRAFMRD
INRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAASEFG
LWLQHKGAVLFESAPALRQIVEAVARLDDTVLPGMMQSASQAPESLPNQVRELQELVARI
KHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISLAQRQRSSFSVLLLDIDHFKA
INDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAALAAAEKLNA
EIRRHRFMIAEAGAMHVTASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSVEA
>A0A6J4G0F8|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. SS-4|TrEMBL
MDRAGRILLVDNSRAYSAIVAGTLSERLGFSVILADSLDGARKALESGDDGIMLVLSGLV
LPDADERQVVDFFVGRGLPLVVVSGVFDTGIRERILARPVIDYVLKDNPASVDYLAWLVE
RIARNRDLTALVVDDSRSYRMQISSLLRLYGFSVLEADDGARGLELIRDNPHIRLAVIDY
QLPGLDGIHLVRRIRAIHPRDRLAIIGISSSQSSRGPISAQFIKSGANDYLNKPFLPEEL
FCRVSQNVESLESIAALRTLATTDYLTGLSNRRSFFEIGPRRLETLVQQGEGMSVAMIDI
DFFKRINDGHGHECGDAVLVEVARILAASVRAGDLVARFGGEEFCILAAGLAGDAAMAFF
EGIRAAVEAAAIVFNGAHIPVTISVGLCPVAQDSLGVMLAQADAALYRAKQSGRNKVERA
>A0A1E3GUI6|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MLYAILIITLTVLVIYQNYQQQLAAYSSQVNQQIAQRNQLLALMQAQLLESKLEAIDQTL
KLISSHPDFVSDPEPQTYLLRHYSINNPEMQALLHVNADGLLRYPQHLRGPLDLSGRDYF
VVHQTTRTDKVYTSKPMLPGRGHEDPVLVISRGLYDAEDNFQGVIAAVIDIKTFSLALSG
ISVNAQLFSSIVHEEGEIVFRVPYQDFEPGQTLDYVTEHIKTDKLPLAGEGIYQRSNGDY
YQFAYQTLPKWRLHVFVGENRAVVDELLSIYKFSHLRNSTLTALSLIILIVMTAWLIGRR
LEINQQLIESKVALQQSYQRNQAIIKAIPDLLFTIDRSGKIVDFEQGESVPLLLPEEDFI
NKHISHTLPDFLARRTLKALHKTLDEGESDYYEYELNLVGNQHYFMARTSPINQNRMLVV
VIDITERKKSEIALQWQATHDSLTKLPNRVLFYDRLNQAIAESARYKQPFCLLYIDLNDF
KAVNDTYGHLNGDMLLILVAERIGDTIRESDTAARLAGDEFAIIINHSNYEEAQQVTEKL
RQQLALEYELNEGVILNISASIGIACYPHDGKNADELISYADDTMYNDKRSTTAESS
>A0A1L8CM88|diguanylate cyclase|EC 2.7.7.65|Mariprofundus micogutta|TrEMBL
MSQMENLNQLLDDMDDIRPIVIAAMPDDFELRNKTRRMISILEQLRQSPGIPHDTYVWVI
KLFAKFLDVEHGAMLRPTHSGTIPAESRAKLESQAMERLNFFQEAQRDLPATYSILDRSS
NLIGKHTAVDASLKERAQHLENLIKQRLQQDSSLRAELHQLINAFSPSLEAISKVLEEAG
EESPDLKLAKQLLEQDLPDDIDQARAMLQTAREGILKAGNKITSASEKLHETLQNNMQQL
SQLSQQLVEAETEARNDPLTGLSNRRRLAEFLKELGQSNFCFVVVDIDHFKKINDTYGHD
VGDEILQQVGDMLDDCTRKTDLAARVGGEEFCIVFPQTDLTTSARLAESLRESIAMMPFR
TSGGIIELTISIGVAEHIVGKEHSITFKAADEALYHAKTHGRNQVTCAPVEKH
>A0A2S8Y8C7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. MYb187|TrEMBL
MYPMQPKPSTASRSRLFLPLACARPRRTVILCFLAAFVITLVLAGRQYWQLHQRELEDRQ
HNLHLQALAIETVVYHGKSQLQFLRSIAERVLVEAQNQPSMRRNDAIDLAIRNSHQPVWG
LPVPKSDAPIRAIGDAQVATIHGLSRDHEQLVEDLHLSRAMSQVLPAQFQSGGNLERILF
LTTSGIVIAYPGVEDDQLEAVLRKFTSSPLMHLGRAYTEDLDITFYPLPGGDFGKIPHLL
LSSPVYLNAVMRGALIYDLPQNKVQEYLYQTTEEDEHHALIDNQGNLIASSDEVFSPHEG
NWLKTLPASPRPLALPTLFQRDHGTVELDQGYLQYRELEGIDLMLVNYISAADLRTAVNG
QMDILFLGVWALLALLMALTLYIVDRLFKGQLRLNRQLREIGLVDSLTQLANRRRLQADF
GGLLQRLQDNQPVALWMLDIDHFKNINDSWGHSAGDEVIKHLATLLRALVRNKDLVVRYG
GEEFCVVMPETSLAEATQVAEQLRSATAQSVCVPDASTLLASAPSLEIHLTVSIGVAELR
IDACQGLEDLIASADRRLYTAKKSGRNRVVNHD
>A0A1E3GT37|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MTRGSMFEVVKKYRHFLLPLSLVVIFDITLLAMNYGISAQLEASSININIAGRQRMLSQK
MTKSLLLMHYQHQQGMDTQAAYHEVMDAMSLFDQTLKAMSLGGETLSADDQLIQVKQLKE
TVIQRTLMQSIELWEPLYSSIQQMQLSDSALNVLVDAMVADNLQLLYLMNKLTNQLEASA
KRQTYLLRGLQTIIVILILLSFGMAINRLIRREQYFSKLMEKSSDIVIGINSATSRITFM
SASVKLLLQHDEMYYLGQPYHRLFSQESASRISHLLLLAKKFRPLPYNRCEVQLVRADNE
LIDAEMLLQLNRSEDGRTIELSADIRDITERKQLELALTEMAHKDSLTGLPNRAQFSLLA
EQAILQAQRKSSSLAMMFIDLDDFKSVNDMFGHHVGDALLIEVANRISQRLRASDTVFRI
GGDEFVVLLSDVSHNQHLQHVGDKIIAALSEKILIDNCPCQVGASIGIARYPDDGEDIDA
LLKAADEAMYRVKQSGKNAVAFVA
>A0A2T0BAI6|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MNVVYDKRKQTNDIVSVVKLMSLLFSGMIFFNFIADFYKLTVDNSNYIIIMNVFIVPVFV
LALIYALWAFSTTKKVPEKYIALIQLAENFLFILIFFGIVLITEAEKSDYKFLFLFIIIT
ATIQSGMKQGMNIAFFSSAIILTIALVYGPSSGENLYFEKDLILAGVFILTAWTIGFYVK
TEDEHIRKLESMVNQDGLTEVYNHRFFYDVLREKLISYEKDNKSISLVFIDIDHFKNYND
LYGHQKGDEVLKIIGSLLKNNVREGDVVARYGGDEFTIILPDTSEQNAIRIAENIRIKIE
DTYFDGEENQPKKKLTASIGISVFPDKAKNEVELIKCADDALYRAKFFNKNRVEAYYSIL
DDLKEDIEDEHIDRITSIKTLISVINAKDRYTYGHVERVVVYSKLLTDKLKLSEKDKKKL
IYGAYMHDIGKMNIPEEILNKKMPLTKEEWEILKQHPAYGVEIIKPVESLIELSPLILHH
HERYDGKGYPGDLKGENIPYLARVLTVVDSFDAMTSNRPYSNRKTHEEAIEELRKCSGTQ
FDPFIAKAFIEVIEENKNNIKY
>A0A8H9DZ04|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHC
>A0A8H9ADU2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDSGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A8H9DYN8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2X2L754|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A2T0BGM5|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MQDSGLGNDEIKEEFEKYQRKTEMQMQTLSKKNMKLEKDINVLANIVEISKYINSFLSDE
NLISMINDMVLGLLGVAYSTIFLEEDGELVIKATNVKNKKVELTSQEKVYIQLGKEYLIN
SLDGIRDYKCLNVKICSVMAMPIQIRDKSFGFILVEHQLYNFLDKEHKRFLKSIASQIAI
CIENAILYRELHEASKKDPLLGIYNRRYFFEKVEDKALANPDKRYAVVMMDLDDFKKIND
DYGHQFGDQTLIETNQAIRKLLVDGDVLARYGGEEFIFYIDSFKDKKEVYDKIEAIRQSI
SGNVIDNGEDSKIITASFGIGYYPEDGDTVSEIINEADILLYQSKESGKNKVTYYGNKQ
>A0A730K623|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 43:z4,z23:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQSFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A2H5Z1F0|diguanylate cyclase|EC 2.7.7.65|bacterium HR27|TrEMBL
MLEQFWRHEVTGEPLRLEYRFLRKDGETVWLWHEVRAIRSPDGAIEGRQAILMNITERKR
MEEALRAAEERFRTLVEQVPAALVILDPHAQWLPDGLPGYRTLYASPRIFDLTGYTPEEW
EQLGILARSVHPDDRPALLEFLQRVEATGEPANLEYRFVRKDGQIVWHRLGIWPLRAADG
AVSHWHALMLDVTREKEAERALREAEERYRNLVEQLPAVVYVEGVTPVRYPNGRLDRPLL
YVSPQVEELTGYPPEAHQRDRSLWVRAIHPDDYQRVRQETREAWATGRFHSEFRVVHRDG
SVRWLESTARLIRDADGKPVAWQGVMLDVTERKRIEEELRVAEERYRSLVEQIPAAVIVT
AAQPVLLPDGTLHYPITYVSPRIEEVTGFTREEFEGTPGLWFSRMHPEDQPRVFVEAQRT
DETGEPFQVTFRWQHKDGRWIWLENRAVMMRDTQGQPLFWHGLLIDVTERKRTEQLLVTQ
TTLLRLIAEGAPLSEVLELLCALVEEQAPGLRCSVLLLGSDGRLHHGAAPSLPPEAMRSI
EGLAIGPEAGSCGTAAYLNQPVYVTDTRTDPRWADWRDIAERFDLRACWSTPIRDASGGV
LGTVALYASEARAPRPEEERLLELATQLAALALEHWRESEELRHRAFHDPLTGLPNRLLF
LDRLEHALARAERDGGIAVLFVDLDDFKRINDTWGHGAGDLVLQEVARRLVRNVRAGDTV
ARFAGDEFTVLLEGVSDPDEVRRVAERLIAALAEPIDFELATARVSLSVGAALGIGSPLP
DSGTLLLAADQALYRAKRRGKSCAELVLLGPQVDRTGA
>A0A5E4U228|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MVKSLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSAMQAQLDTQVKLVAEQLDDKLR
GKFLALHRMARHMGNPYAMTIAQFDAFATMSVSMPETFNTFFVAAPDGRMLYDSTFPATA
INIADRDYFRQLLAGAPQAASGLIAGRITRSPGIILAVPVVDAHGKTIAVIGGAVNLLRQ
NFMVDLASNAIGATGRYCVTTNEDPARYVIQADVTKILSPVGPAQTLCGVRDPGPEHLLH
MHPLVARASMATTGWSVMAVLPGTEAFDPLARVRRRVTLLAIAVIGLAAFAMWWMARHML
RPLDTLRDLVQRSASDMHAVQSLPVQRADEIGALANAFRDMMEQLRDRTEALEGSREAAR
ANVRRMQEIADRVPYLVAFLDSAERFAFVNRACEMRLRHPRERILGATVSELLGPSLHRE
FAPHLARAFAGEATTFIWDFGEDVAYRCFEVSYQPEWAMHNVLAGVHVFVRDITVERSNE
RRWRRESHTDHLTGLLNRKGFDQALAGA
>A0A4P0YAD5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNRILTAIILSLFVVTGYITYLVHERQSELQKFTRYTDSWSMSQMVSEYMRLESRLAGMA
IGAEGADHDEVRLRLEIMMSQIELLQEGDLGKFINKSEQRKTVVATLIRNLHLLDKQVDT
MTPEQVRQILPVLSELDGPLTSIAAATLTQDINIVNITHDKIQHLYYIYSVISILLIAMC
ITLGLLMLRQNNNLRRAHVRMKTLANDLQASKEKLQVQNRRLQYDAYHDSLTGMPNRLSF
WQRLQEIVNQVRPYKGCAVVMLFDLDSFKDVNDTLGHDAGDKLLQDLASRLSFSAKPPRR
CIALAVMSCDALLRSH
>A0A2X3E1R4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDGGNAHQTYLANK
YPGPGRHPHYE
>A0A486CVZ9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALYGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A5C6FEP7|diguanylate cyclase|EC 2.7.7.65|Rubripirellula tenax|TrEMBL
MWLDLIIAMSCGGAGLTCGWVMHATRHLPIDPINGDSGDSSTTTLTTTQVEEVETRREQI
SEVADQLRAYARTMAADVDAHQTTVQAVNSQLTSDQTDSPEAVFRAITQLIEANELMQSQ
LHSAQDRIHEQAMQIESAERRAETDALTRVPNRGAFDKHLASQHAKGHANAGTLALLDVD
HFKKFNDVYGHRAGDEVLRVVAGILHSRLDKYGIVARFGGEEFAAVLDGCPVDRAKELVD
AARVAIGEREIVFEEKRLRVTVSAGVAQLSAGEAAEGWLQRADDGLYRSKEAGRDCGHWM
DGTTPIKITPAKSTASNEKSDSASDAAATGTAVTAIEAAKPKAKTFANLPGRSELNENFS
EVRDRTQSTVSMFVMAIRCNTESTANNMRSLMQIIRATLRSVDRLGCDDESTFLVFMPSV
DEETAQNRSVQICRSASAIGIGKSELAMNPISIGVSQVRASEEFDDVVDRCVALAIEAKE
EGSEPTRLDTAGQLAL
>A0A486TXL6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKRNKLRHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTL
PVFGVSGSVVGNNPILLKDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMTHYSQAISALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLAVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVL
PNTTLQDAVAVAERLRLRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADR
RLYLAKQNGRNQVCFRSEA
>A0A330T2M4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A377WBX9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLWAWHVVTKAMLLTPPHFNYLVIALLSILFIGTIAFSNNITAFTLHSLPTFLACLIMAE
GEQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMHERNTLNDLSMLDPLTGLYN
RRGLQNRLDTLLALDGDNHYVLLLDIDHFKAYNDHYGHMMGDQALIRVSAAIRNAVRSRD
IVARFGGEEFMVLLTNSSEETAWKTARTYTSAGL
>A0A378F3I5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MFTLFQLLSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRQSNHKYVHSYQNSIR
DPLTRLYNRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAAS
VLESHSRVDDAAARIGGEEFTLLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGV
YTTHDNSVTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A447RGL2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKNHPD
>A0A862ZHP8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A0C1MZZ1|diguanylate cyclase|EC 2.7.7.65|Candidatus Jidaibacter acanthamoeba|TrEMBL
MTAKILVVDDIVFNVKLLETKLKQEYYEVFVANNGVEAVKKAKELNPDIILMDVMMPEMD
GIEATKIIKNDPNTMHIPIIIVTALNAQEDKVNGLSAGADDFLTKPINDHALITRIKSLL
RLKFMMDELRARHVTSNQLGVGEEIIIDESNKIEGAKVILVDDDVAQAKKIKEKLNSAGI
SVDIVTEEQETLSLAEKNNYGLFIISTQLIDSDGLRLCSHIKNHDKLRGIPILIIVEEAD
EKTLTKGLEMGVNDYLLYPVESNELLARTTTQIKRKNYQDALRENYIHNLSLSVIDQLTN
LYNRRYFDIHIKNLVTNAASTGKSLSLIMLDIDHFKNINDTYGHQAGDVIIQEVARRILL
GVRPTDLSARYGGEEFVVILPDTKLEDAIKVSERIRQSVEMYPLTTVDSLEIKCTLSLGV
SALNSDDSPENLLKRADQCLYKAKEGGRNRVVAEEAFFT
>W6KDP4|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MFEKTHQKERQSTKESGRGEGLRCKVCWHVTLRVFLAIVAVELMVLIPSYLKFEHDWLDE
LADKGRTVGMTLLSTPMQSMPEEILDQLEVAGMGTVIRGARLLDKEGNSLGSVGEKPKLL
TGPDNQDPILNDDRDRLEVLVTASQANGGRSLILCLDSSGLDAALEAYVLRIAGLVLVIA
LFVTIVTMLVISRAILMPLLTLRHRLQAVGDDPEKADQYQAPEAREDEIGDLQRAFNGMI
TRIAADIGIIRATETQLREAHDRLEEKVVERTRELSHEVAQRRHAMELLEASQEQLTHKA
NFDDLTGLPNRLLAMDRLEQALGVARRYEQKVALMLLDMDNFKTVNDTLGHNYGDQLLIE
ISKRFGDCLRDSDTVARIGVEPDAQGDGTGPDTVARIGGDEFMVILPHMDHVTDTDIVAR
KILEACAAPFDINGHEIFITTSIGITIFPQDGQSAVALLANADNAMYEAKRIGRNGRCFF
KGEMNARVRERHMIESQLRYAMEKEELSLAFQPLIDIPTGETIAFEALLRWRNPDLGQVG
PDRFIPVAEGTGLIIPIGDWVLHEACMAAARLAKGLGRPIRAAVNVSVRQFRGGAIMKSV
ERALADSGLAPEHLDLEITESLLIEDSDEIARLLRRLRNKGIRISIDDFGTGYSSLGYLK
RFPVDILKMDKSFMSGITKNDEDRALARAVLSMAHSLGLEVVAEGIEDADQLAFLSANDC
DIGQGYYFNCPVPEQELLNFARQN
>W6KMN0|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MLPRLTSKAFTDLAIWMVVLGLIVGAIFPFFAVMLGVASDQVMTPAFFFATLGAGLALGW
LNYALAHVVFRPRLQIMSQRMNKVEDLFSTHMFEDGPIECDPLTCHVAEDSEDEIGECAR
SFNHLIQTLTDAHDVETAVNTFSRTLSEHLNFDELTTEAIQLLLEYTSSTAATILIEQEG
QMQVAGAHGIRTPAKLADSDHVRHVLRTGKAVTLDLPNDLQVDGTLTDFRPRQVLMAPIE
YNKAVFGILVLAAPQSYEMGTKRLLDLLLQSLGLALQNSLVHERLQHMAAIDPLTGLYNR
RFGSKRLREEFVRASRNDNTISVLMFDLDHFKHINDTYGHLIGDRVLIAVAKAAQKLFRE
GDILVRYGGEEFFAILPGASTEDTRDLGERLRRSIEESEVQDGDQVIRVTSSVGGAAYPD
SKSYNNEEELLKAADEALYAAKQNGRNQVVLQK
>A0A8G1GUI6|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MPNSLSLFSDQLAEISHQLAENAPLQALALIDEISNTSYQFTTPKPRIALLMLKSQAETE
LGQCHALIATLNEALSLSQDDDFAAERLQILNQLADQVYTMGDYRQSIQLWMNSIELGLE
LGDISSAILAFISIGGIFNAAEQHERALKLHQQALHYSHKLDNPHIFYTLRLYLAADYMW
LKLPNDTLTILNQADPILKKCNHFNGIAESHLWRAQALFQLERYAEAIDHLQQGLQCAVQ
HHHYWASIKCAYHLGLILTHQKRHAEAEQALLEALATASDNEFMQLLRDCWLGLSALYED
MDQAQQAYFALQSAHSFEHQLAKSAPILEVEPRILQRLAALETRFSLEISRQENRQLLEQ
QAQQIQKLNQLLTEVEQDALTKLANRRWLDTHLAPQITKLNAADTISILLLDLDHFKQIN
DDFSHLAGDEVLRDIGLILQQACRDVDTPVRYGGEEFLVVLKGLNLFSAAKVAERIRTQV
AQHAWPSSIEGRQLTISVGVAQAQLGDNLISLIERADLALYRAKDLGRNRIEL
>D8G6R5|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MLQKLTLNNKNSLEFLLDKLLSLRRIEYLTLDRELKIRETSLKVQQFADFPGEVVPGNDV
RAGFLELIGLEEILIEIIKQPQKHFEIQGIARNFKNSSYLYLDLYIFGYQEKDKDEKLII
FYEDVTDNMTAKQALVQVAHETSLLLSALATAHDYINKIFNSIADVLLVTTATGKIKIVN
QAAQLLFGYSEVELIGQHITLITAEEKLLHQASQVLSSVDNNAANQVTVVCKTKTNLKLS
VAFSCSISQTDIKGQRGSADFTQYFVYIGRDITDRERIKKRQAAHYAVTQILSESTSLDD
ATPKILQAICENLGWDIGELWTPADGKISSQVSDRAQVGHELIFSCLRPHSPLDATPCLQ
RVGVWWQRSLPVSNFMENSEAITLDPGKGLPGIVWVSGCTQWITDVVKDPNFLRSEFAAQ
VGLRSAFAFPIHTNGEVLAVMTFFTVEEQPPDRELLEMMTATGCQLGQFFKRKQAEEELR
AAEASIRILYEQEKQQSEELNLKNFALEKTKQELEAANRELQRIASIDGLTQLANRRCFD
ETLEREWRRMARERSPLSLILCDIDFFKLYNDSYGHQGGDECLKEVAKIFYQNARRGGDL
AARYGGEELALILPLTDAKGALKVAEIIRSDLQARAIPHAASNVSKYVTLSMGIATVVPT
HESSFEALITAADRALYRAKAGGRDRVATSF
>A0A517VC72|diguanylate cyclase|EC 2.7.7.65|Gimesia algae|TrEMBL
MTPVLSTSLSTLPNEILICFGAGLLIAVSLGFATGYFLGKSAPVRNLRRAQKHLQNCYQH
VKETLDTAYTACTLLENFPGTILTNDQTRELNSKRTSLLSLINRLVERKNTEPDKTPPVK
KQEKKKQQDFPTLQWAFQPEHSHLKLPDSSAFEANLEMMLLTGTATDNHSGLLLVQMNQH
DQLKERFGIMAPIKFMKTLSRLIMHQVRDEEVICLWKSDTLAILFPGVEVDAGQTCAETI
REAIRHHHFRLESNSPEVVVTASLAYLNCVPGDSAELVLERGLHALAQSQKQGRNQLIIQ
DSHSYEHKQAV
>J5XV82|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. OBRC7|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNAFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
EPLKNSTQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDDASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLNRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLVISWLVIRRMVRNMSVLQTSLEWQAWHDGLTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDRYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSKSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVSAEG
>A0A212LIK8|diguanylate cyclase|EC 2.7.7.65|uncultured Pleomorphomonas sp|TrEMBL
MLKGVFPGGRVGIFAGCGLLYAGLSAVMIAIVVTAGVRTPVWPADAVLVALLANRSTGDR
LAGVAGALVGWLLFAWYRGGDAHFFLSILLVRAVTMATGLWVIDLVRAWARRSRNEELFE
VAAALVATVFPPLASLAVALLLSAAGVLSRTPMPLGVWWGGATAAFAIFLPALLYLQRDA
ARRGRRPAWLNRGVFAAVAVLFPAGAVAATATLPEPMVFFVVPLLLTSFVLRPVDMAVLS
GSVWFATMMAAYGLADTPRTPMLLPLGVSVGALLPIATCVLLERLRQRERDLAESENLFR
RSMDDASIGVTIIGGEGQYLKVNAAFCAMTGYDEAELVGRSFKDITYEQDRDELDSFRNG
ILDGTVRSFKAEKRYVRKSGEVFWAEVSVIVVCDPATGRPDRLIAQVEDIDLKKRTLQAI
AESESRWAFALENGQQGVWDVDKPGGRLYTSPTWKRMLGYEPEDVSIDGGDAWLELMHPD
DRDRFLAINNAHERGETEWLEAEFRLRHKDGHWVWILDRGKVISRDADGKPLRISGTHTD
ISRNKAAEREIQLLEERVRLAVEAGGIGLWSIDLATGVATWNGETFGHMATDDTDRQSLE
WLRFVHPEDRAGLSEMLRQAAHDPEARVNTTCRLLSPVRGLVHIRVLADQVTLSNGDRLL
LGTAWDISEQVSAAQALRDEKERLRTTLHAISDGVIATDAEGRVTLINPAAQRMTGFSEA
EACGHPIEDVFQAVHDDSGHPAASCVRQVLETGAPVERLGTQVIDVRGRDIHYIREAAAP
IAATADGRAGAVLVFQDVSAERAMQRSLAHAASHDDLTGLANRRHFETRIQSMIAAARDD
DSRHGLLFIDLDRFKIVNDTAGHLAGDALLQEVARTMRSIVPISDCLARLGGDEFAVLIE
NCDRQFAAFVGEKLIDALGAIRFTWEGKVYEIGASAGVTQVDATTASAEAVLAEADVACY
AAKAAGRGRVSVFLQDTGEAQRHMSDFRMAARIRETIESGHFVLYAQEIRSIAEPGTRGR
SLELLVRMLDDDGSILTPDTFIPAAERFELMGTIDRWVLAKVIDDFGPAIMAVPGLHVAV
NLSANSLNDPTLWRYLADLFRASLLSPSRLTLEITETAVINSFEVARDFIRAARGVGCRV
SLDDFGSGLSSFTYLKSFDVDAIKIDGSFVHNMADSTYDRTVVRAINEIGRELGVDVIAE
RIEDEATLRELAALGVSYGQGYLFNQPRDFHAVLADYGVDMDEDMAEPLRA
>A0A142Y157|diguanylate cyclase|EC 2.7.7.65|Pirellula sp. SH-Sr6A|TrEMBL
MPRLKITYKMAIILATMSFGPMVAGQLTGLFQDETIELQKERVEKSRLVATACSTQLNNV
DSIKLQMGCRDLLRKIEDLRSLRILRHDGLVLYASPGHEQYWTLPIESPSTLDQVRIPLM
RGNSVFAELEIAFQPAAPDMVAMLARWLVVAAIGFALNFGSFSLFLNKALSVLDPKSAVP
KRVRNTLDTIVGGVVILDAEGKILLVNDSFAKYVSQSIDELTRQRLNQLGWSREASEEDW
PWEYVIREKSQKAGVKIHLKSGDEPRTFMVNATPVFDAQENISGALVSFEDITLMEVQRR
HLLTVLSDLETSKEQIRRQNEVLHELATRDGLTGALNRRALLEKIDKLWGARNQGDRGLV
TIMMDIDHFKKLNDQHGHSAGDAVLKEVVKTVSRIVEGRAVLGRFGGEEFCVVLSQATLE
EGAALAEEIRGGIATELANPYRVTASLGVSSSLHGAPTIEAQIEQADQGLYAAKHGGRNG
YRVWSPELEEQSKEEERKKAAKLASTDVEEQPVSYHAVVTLNSALIAKSPVIAAHSHRVA
EICVTMARGVLPVGQLYTLEIAGMLHDIGCLATHQDAEHSDEHVSPDRVAKGVQILRSAF
QSQVLLGIVTHQNASVREMDALEDIAVVAGAKILAIANAYDIATSELSESPLSHEEAIAW
LRQEVGSRFDSEWVERFADSPYGWRPVSGMGDVAMLDSALMVGYQLERVIHCFESGNLMG
LKPRLESLQTLARKIEMPWIGRIIEELQGDLERKAVADWGSLAPLVQDLVEICLSIQRAH
LRSDLAVCEPTVASVR
>A0A385Y3R4|diguanylate cyclase|EC 2.7.7.65|Dickeya dianthicola|TrEMBL
MKKYNSDERRVSKINEYHLLDLYLQQSFQNQVRLFAHILNFPAAFISIIDNDKQWLIFSE
GINIECTDRELAFCNTVISTATTLYIPDTLTNNPFCEHPLVIGAPHIRSYFGIPLVLDNV
VVGTLAAIDYQPRTLDDAVRETAAFVASTIESLFRLHNERLHREQEIRLLNNSSVVLINW
QQDNMLHISYISPNAQHVLGLTEEEIKHNSTVMENYIHADDYENLLFTLDNHKKGVANLE
CEYRFLSPGGKTLWIRQLSIANYHHNGKLSHVQALLIDNSHQKYLQKLLVDTNTQMRLVL
ESSSLGTWDWDLGRHSIRVNKQWCEMTGVTQDQFDSSLDYWQQLMHPLDRERMVLAAESC
ITGQATLINEQYRMRHNKGHWIWIETYGKVVEHNEKGKPIRVAGTHRDITEKKNKELQEE
ADKRLLELINRAQKIFLEKTDIQEACMSIFDDLLSISESEFGFIGQVRDHDEKKVLHIVA
ISNVSWNGDSKNSYNTFLQNKLNFTSLDNLFGHVVITGKPVITNSPRTHTASRGVPTGHP
ILRQFMGLPIYFRNEVVGMIGLGNRFDGYNERQLRFLSPFVDTLGSLFYALETQRAREEL
EAKLLEMANTDALTGIHNRRSYILETEKCYRNHEKNTALAIIDIDFFKKVNDQYGHHVGD
VAICRLAEIITGKLRTDDFVARLGGEEFGLIVHNANLDNVDAIMNGIRTEVENTLFTVDG
YSFHFTVSIGATFIKHRNVQNLKDSFESDMKRADDALYEAKNAGRNRVVWK
>A0A3Y6QG14|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQIAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C3JNE7|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MHNIDELIDNVRHNEQIALKFFDIERCILSIGRCDQFVSTLTKEVQKQFNVPFVWVNLIN
EAPLAHLIETLEKTVGLKDRVLFTRRSAMIDAIGTGIKTVQVNQDIERYWEVIPQSYRGI
VGSVAISPLTIDGELVGLFCQADQDPTRYDSATKDTFLLDQLSIKISICLSNVTAREKLE
YLATRDPLTGLLNRRQLELMLEREFARCKGQNRDLTAVFIDCDAFKSINDTLGHNCGDEV
LEYIAKRLLRHVYKQGLAFRFAGDEFVFVIPGKSYEQAIAIAESVHDYLQSNPLRYKSNL
VPITISYGGASVLSDAPSSYKQLLKIADERLYNYKNNRKRSVPTKVFKFLNKIR
>A0A485CY00|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MTASDIYFNRSTIKSINIIQYQEHLTPIYLLNIKLDLIYFIIDNLWLAFIYVMSTWLLCR
YTKKQMTRHAELSKDNITDTLTGLYNRKILNEALSNKIDAMLKKNIPVTLVSIDSDGLKR
INDTLGHDMGDKVIQSLGQAIEQSLRKSDYGIRPGGDEFLLILIDTDYAKRLRNHRPNQR
KLTPYG
>A0A3P4B258|diguanylate cyclase|EC 2.7.7.65|Pigmentiphaga humi|TrEMBL
MPPIDLRTVTLLTSVMGVLMSIVLISVYRGFPSSIKGLGQWAGGSILYSVSAVAFGLRGI
APDWFSIIAGNVCLLIGTACWLTGLQRFYGQPPARFWPAAGIAAGTACICWWLLVDPNYI
MRLASFTAILSVFYGALFIVVVRHGPRHFDTGFLAVLMLILTVVLVVRCVTSLMPDFTGT
GMFSDDVVQVVYLVTYNFMMLLLTVGLVMVATHRLRTELTRHAEHDPLTGLLNRRALVSI
YERACRQRSGRHAPIALLLMDLDHFKAINDLHGHAVGDAVLQDFSRRAMAAVGARTCFAR
VGGEEFVILLPDTDAARAHAIAEAVRLAVQRDEDNGLPAYTCSIGVATMPRSACRMDAHL
QAADTALYLAKSRGRNRTKLADGMPVAAVARHAAAPTP
>A0A1C3JPL0|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MPDKSLSIRKSLRARIAAAVFTMVLLMLVSGAVSLYYFSQLNIAVSKQSEQELPALKTLN
SIQLSITRLATLSNEVSNSNSPAYSRILMSQVRQQVEELQLSLKTLGSANEQIQRLTEIV
AKVEPSVMNMSLSKAMLDQVEDALFTRTTEALQQTIEHYKMVEEADTKALLDGLWQDLNQ
LAANEHLYEQNRTLANIRKTLASLSQVDSASFQAINPLISAPNGVFELLSKKEVYRTEVL
GLSTQNRILLGSVVDFGHRVYIETEDNVTFQANDISASSERFIDVLTVMFIIQLLVALSL
IVYLHRELFRRLQALKHLVGQQKKITADDVALFDERNELGVLVKQLQNYVDTITAQQQQI
EATSHQLQMIIKHSHMKVAVFQGEQLLYCSESLSQLFSERELRCVDEFPESVQQSIRASK
SGLKAVDKATYLDEHNQHWYEIVSDVVFWDNQRADLVCFMDVTEQIKAEQEFKRTLMVVE
SEAKIDPLTGLLNRKLFDTQVASFQSGEGEGGYAVLLFDVDYFKHYNDQLGHLQGDNILK
MVASVIKRNTPASGLAIRYGGEEFLVFIPDCPERRAVNIAQSIVEDVYGQRVPHPTSPHE
YLSVSCGISVQQTAEDAVLKVFDQADKSLYKAKNSGRNCMMVWRALHQSESTEEPPLTQ
>A0A2H6FVI6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MAVLTGGIKTYKSMTKEELIQELIMKSNQLEEMEKKSIQDQVGFRRLATMVRDSNDAITI
QDLDGTITEWNRGAERMYGYSETEALGMNILDIVPDLSKEEAVGLIQQIKTGRPIDSLET
KRVTKDKRILDVWLTITKLTDDNGRVTAVATTERDITERKQMEHKLKLVSMTDDMTGLYN
RRGFRLLAEKLLLQAERNNNRLLLLYCDLDNLKVINDRFGHREGDQVIMDFVDILKNTFR
KADIIARLGGDEFTVLVTGVKNLWSEQVIIKNLKEKISGHNEQERRSHPLEVSIGASYFN
PVHPCTIDEFINRADNAMYKEKKKK
>A0A4Z0LE36|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Poona|TrEMBL
FEQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLA
RSSAMLTLETMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWF
TSAQPYVADEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDN
HLRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRV
HTLREGIQGNFGSISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLT
RLYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIG
STIRAHDIAGRVGGEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTRRICASMG
ISRAGE
>A0A655WVY2|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTGIRLLACCGVQICSVFLLIISSSAYAVVEHISDYFVETWTSTDGLPHNSINSIAQTRD
GYLWFATWEGVVRYNGINFQVFDRNPQTGMVDSGTRTLLPMDNNGLLVAGARGSITHRQS
YGWQSFRSAPSLVNGALIDDAQNLWLAIEGLGVVVRPYLGNNLYGPDRWLLTDASVYRLV
KNQHGVIFAATDKGLYRFNDWQASAMELPIGRYERINYISISLNQELVVATDQGVWINTE
EGFQSLFVPLEKEVVTLAEQDRAGNWWIGTVNRGIARLKNQQLQFLEPSRGLPYSRVLSW
YQDIEGSVWVGTNAGIMRLRDAPFININSDKGLVGDYVRTLLPLDDRRVMVGTSRGLSII
EEGLAHSALMPQVGARPSILSLAKADQQGEKVWVGTVQKGLLLWQNGQLRPVLDENNGLP
SSEVRAIVTDPQDNLWIGTSNGIVKRTPQGVLTTYNKDNSPLPDDYIMALAVDSEGKLWV
GSAVGVAYFDAQGKIRPVDLTKQEQAQYVFGFYMESDYVWMATDRGIVRYRLSDASVSLV
GRAAGLPIDKFFQMLRDSEGHVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGDGM
ATSQANGGTNPASASLPNGELLFATAKGVASIKVQRLQQLSELRLPVVLESVSFDSEIIN
PDQQYIAAAGTNRVSFGYVGLGFVMSERLQYRTKLEGFDRDWSYRGHNTQAEYTNLAPGK
YRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIVMAGMLFLALAVSLVMWRIRILKR
RELYLVEQVALQTQKLRLQAEKFERLSKEDDLTGLANRRAFDMYLKQAFSRLQNPDQQVS
IALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYVGDKTRVARWGGEEFTILYVGDPKQ
AWGYFEKLRCKIEQVDLSAVAPGLNVTVSIGFADAALDAGRDVKFVERFEQAADHPTDTA
YPEGFYLKGFACKVL
>A0A2H6ARG6|diguanylate cyclase|EC 2.7.7.65|bacterium HR38|TrEMBL
MNPLEAPYPVYLVRETEVVRNSLAEGLPLPQGDTLEVGTKTYHVVRLPAPEGTYLLLLEV
SHLAVRAKAYQSLLRVLKGLVQHEEPEGLLKDLIREAVAVVPGAEAGSILLREGGFFYLV
AQEGFSDRLLMARTSLEEEIFWYGLGVDNWQKGRPRVLKGEEVRHLSSLSTVEARPLFFE
HGRLLEIQATLGLPIVLEGEVLATMNLDSFSDPEAFSPLSLELAQAFALEAALLLKALKE
RQALQEAARTDPLTGLGNRRALEEAFPLLLQEARTLGEPLSLIYWDLNGLKALNDREGHA
VGDQALRSLAQALRNLSRRRDVAFRIGGDEFVSLHLGLKAEEIPALIARLQENLPYQVAA
GGLLVEGEDLEVLLKEADKRMYRAKRARKGL
>A0A656AEG6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIDIDHFKSVNDLYGHDTGDKVITQVVEIMNTHCRELDLLFRLGGDEFLLLFENTSLTDA
TLVMSHIGCRIQQTHYPYHAKVTVSVGLAEALRTDDPEQWFKRADQALYHSKKMGKNRVS
FDEEHVIELNGDHCHALLGSTHGHR
>A0A0B7JBP3|diguanylate cyclase|EC 2.7.7.65|Photobacterium kishitanii|TrEMBL
MLTLKGFSSNYSIYRNIALQLTVCFSLIYFIFQILIEIHFFGKDTLNAIHNHSIKINILF
VFTLLFVFCYLINCINKWFISPLNQLTEVINDRNNISNNTIIHETNINNTFEYYCMMIKE
IAEKDSQIDLEISILTKEKQAVMRQKQLTSSIFNNSQDVIIIIDSYGIIKQVNPSFCQLI
GVEYENIIHQPLIKFINTAAYKNIKASLSHELNNSHQWQGEFNVQHAINKKNIPVYVKIN
KFTDHNKNNNIQYSIIATDLTTIKEIDRLIHINHHDPLTGLPNRTALNNRLNCELKMQHT
AQHKFAVLFIDLDNFKRINDNYGHQMGDQVLKITANKLRNSVKKSDMIARLAGDEFIAII
NPAAGHDDVLQTCERILSVLQQPIIIEKYRLTVSASLGCYYAHPNKQQTIDEILSQADIA
MYKAKIAGKGCIIECNSF
>A0A7Z1CYJ1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRQDAEVIMKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKIYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDSLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDFIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMQAWGINGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A822TLN8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLG
>A0A0E1CIV3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MARSRVIAVSRCLFCFHFKPALGLHSVKCRSAPAVGRFGACMLLKELAVFEVLSTPIWVV
HPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPT
ANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNT
APMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGG
HKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLT
GLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVD
REDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVE
QLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A822TP10|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVP
LLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNI
GSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFI
DLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARF
IATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGR
VTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSC
EGEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATL
VNDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLQLAGCRIVLSQVGRDLQIFNSLK
ANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGV
DLIYGDVIADAQPLDLLVNSSYFAIN
>D2AAA3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A0M2WP15|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MRAALSESGLEPDLFTVEAAALAAARRMHADANASGAEQRRVLGELIIHYERLMRETRRL
IGRSDRAERDMHLLNRQLQTLAGQLEYRATHDPLTGALNRGAVIDHASRCLAQGDMALIV
LDIDLFKQVNDDFGHPAGDGVIQAVVDCLKGLLGQETAIGRVGGEEFSVVWPTSSRDDAA
QVAQRICETVGRQRHAAPITRAITVSVGLSWNRAGTPFETAYSHADQALYQAKREGRNCV
RQWLES
>A0A482PV21|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium|TrEMBL
MNDENFYKRAVAVDETSSLTPPHDLQRSGLRFARRVRAPRAVALGGMFFPIAAALVTHPV
AGGWWLLLVGWAFVWPHLAWQIASRAIDPRGQEFNNLKADAILAGMWVGLMGMNALPSAA
LLMIVSMNLMGAGGLRLSVIGLSMMAVACLVTLQLTGGSLILMSIPLVGWLTLPVMVIYP
LLFARLSYQIATRLAEHKRRLQIMSSRDGMTGVYNRRHWEQLLRNEFELCRRQHRECTLL
IIDIDHFKDINDTWGHDVGDEAIQALTRQLRTTLRSSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRVHEGLRALRLACAPQVILHISVGVAPLTPQFGHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A349Y6F9|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp|TrEMBL
MHNVPNLDEASQPLALAWAQTLAQTPAAAATLLASLSAESPPGLAHHFYDVLLEDPRASR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQADESTTAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRKHIAQSPVQLGSGQSLSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDRVVLASDDLPDAPGRKALQRG
>A0A0W0XNE5|diguanylate cyclase|EC 2.7.7.65|Legionella quinlivanii|TrEMBL
MSNRLLILDDDVMICKTIQNIARFTDIEAQYTTNPATFLHQVQTWEPELLAIDLIMPGMD
GIQVMTELARQHCTSKILITSGVGSRVLDAAQRTAYEHGLNVVAVLPKPFSLTDLRKLLT
QLNTSVIKLPSNYFDLIEKKPEPLLKSDLSNALEQKEIYVVYQPKIDCKTQELRGFEVLS
RWVNTRFGIVQPDRFIPFAESCHLIDGITYEVLDQALHWFSEIISGPVYKQYLSEKTIKN
LKLSVNISPSSLKNTALFEQLSENIKKLGLEPNCLILELTETAAMEDPVASLEILTRLRM
QGFELSIDDFGTGFSSMLQLVRLPFSEIKIDKSFVINAKHSLESKVVIKSIVDLGKSLGL
QTTAEGLEDQETLSYLCEIGCDQAQGYYISHPLVAKEIFEWIKNKSIIFSTN
>A0A6P1Q4P6|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MKTPEIPENEPQRLNELHALKLLNTPAEERFDRLTRLAKRLFNVSASVVSLLDAEHQWFK
SGDGISATQTARDISFCGHAILQDDVMIVEDARQDERFYDNPLVTGEPQIRFYAGCPLRA
PNGSKVGTLCILDSKTRPFSEEDIHALRDLASMAESELVSFQAATSDELTQISNRRGFMT
LGQMLLQECALRHCFASLAFFDLDRFKQINDDFGHREGDRALMDFADALKISFRQSALFA
RLGGDEFVVLFIDTNQQQAEARLAEFRSELDRYMQPLDRRYRLDFSVGMVEFDPAQPQPL
AALLNHSDGIMYQHKKARR
>A0A447LSE8|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MIKDINNLQRPTFKRTLRRISMISVVITMIVAWMLLSVSSLLTLKQYAQNNLRLQSVSIS
HSLEAAMVFHDGPAAYETLSMLGEQGQFSSAQVVNSNGEIIADWSGTAENARDMMGGIVS
KWVFPTPVVQNIYHDGKTLGEIRLTAMDNIITHFVWTSLGVLTACLILASLISLSITRYL
HKGMVDALSNITEVAHDVRTNRNFSRRVSAERIEEFHLFAQDFNTLLDEMETWQTQLQRK
NASLLISATHDPLTGLANRTAFRQAVESMMNDRSRKIDAALLFLDGDNFKYINDTWGHAV
GDRVLTEIANRLRTFAGDNHCAYRLGGDEFAILLTGVQSTDALLTLIQSLRHALLPPIML
NNGETTVMSMSIGYALAKCTATPESLMEVADQNMYIEKNKRRLVFG
>A0A1S6IM40|diguanylate cyclase|EC 2.7.7.65|Jeotgalibaca dankookensis|TrEMBL
MLATLSKNKKMFINYVMIIFLLLSFVVLFSSVFLQYKSNEVEKSSVISNEQNLLKIENNV
VSNRINKISSDLLYLLDSFQLEDQGDGNYSKQEQQFLAFSSRKKIYNQIRFIDVEGNEVI
RVNYKDNRATLVEQNELQNKQGRDYFQETIRLEQDQIYISRLELNIENKKIIEEDNPVIR
ISAPHYLDGELQGMIILNYSANDIFNQIRQVASISHGQIFMLDSQAYWLYNSHNRDKEWG
FMYENRTNHKFSKEFPTEWEKMHTDESGYQVSKAGLFIYTSVAPSRLFRQTNTTHTYVSS
LEDWLLVSYVPAQSQKGMLFSQDIWLLSLNSLKKNYYFYIIILLIAIAIAALIVTNKSKI
EEIKYFSEYDVMTGVYNRRAGFHKLAQLYKKSADKPVHHSLCFIDINGLKEVNDALGHET
GDELIRSVVEGIKKNIRTNDFISRLGGDEFLILFENLNAYEAEKVWQRIVKYYESINKNE
GRPYLIGVSHGIESFKFDANQYIDAIINSADEKMYHEKRVVKKEMQVLREN
>A0A447LP54|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MLKKAVISEIDNSIITLNQAIRDHFAWANKLIEFALFGDMMDSSFTDENSHQLCAFGYWL
RTQLSQSDEDEKALRTIEATHEIMHEAMRELITGIQDQHKVRENLNNYFHAQLHFLQAAD
DYKTSLISLRNCYDALTGLPLRQLLYKDFARFNASRQRNKTQLYLSLIDIDNFKSINDTW
GHNVGDMILKELGQLLSTNVRLTDRAYRFGGEEFIILQECQSQQNYAAIIQRMMTLIRSH
AFIIPEGSISITVTCGTTLVTEDESLQTLIDRADKAMYFGKQQGRNQCRFWTENKMINIE
KRAPWAVT
>A0A447LIU5|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MTSQTWRSLLQEKYQLSLRLFLFLNALSALFSMLSPLFRVKLVTAPLIIILSLSIAMLIW
RWVSQTRNISLNLISLLFGALWAWHVYIKQPFIPIYESSYLIIALMSVLFVGALAFINNL
KAFICHCLPVIVTVLWLDHGQHTIRMLYAVLLPMAGIVIQHLIQKRNDAFAQGLMFKLME
EKKTLTDLSMIDPLTGLYNRRGFQNRLENLFTLGSERNVVLVVDIDHFKAYNDHYGHMMG
DQALARVSAAIRDAVRSRDIVARFGGEEFLVLLSNSDLELARKTAERIRQRVFDLRIPHR
FNTQAATNVTISIGLAPMHERDFNDAYKLADKALYKAKNMGRNHILSSDEIEDNE
>A0A2T0BMJ7|diguanylate cyclase|EC 2.7.7.65|Clostridium luticellarii|TrEMBL
MIQNVLGIADKNFVKVNIFSGVNSIQHHFYENDIVCFVVYDSDELAGIITEKELIGAHPN
RIIADVMSDKYVCLNGDTYIWELMEIFNTDRELEVVLIKEKNVIVGFITRIVLKIELGKH
IDLLTGLYKNDYIFYYAYKFIMESKEVSIIFMDLDNFGFINKKYGHINGDKILKSIACII
KENIGLDEDIYLCRYAGDEFAMLTLKPLNENKILSERLIESIKSGSFPDEIPVSISIGMA
EYRADNLHEERDVFELVNKLVNSASLASTKAKSMSSHLFVAESMDDICFNEK
>A0A1Y6MQN5|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MKLRLKSSLALLMLIISVVPAAIVGGLLLKQQSDVEANYRIDMLDRLATTIGQEFDYRFS
LLSTSLDVLSRDRLFVQAINNYFLAGHVINSLGTLVKNTPLTKAAYLVDDQWNEIESYNG
IPGLNSFLQLKKALNYRLSTKGKERLKQWVFYYNGEKLMPEKYNPTRRGVVIGVPIFRSM
TDELKHLPLGYLIVVVPIENIKKVLKPYLKDGERVVFRNHRISDMKNMADMSSIIISQDN
VDKKKPTIQKTIKIKLENKYISEPIEYTMVVYMDKYISKNPYINSLKYISLFGVVIILLA
FFSAGMTYRWIARPLGGLMATVRAYSQGEYQRSGRDLRFAEFFMVDKLIRKMAKTIQAQV
SDLAAKNAELNAAYKEKEQANLQLVDFNDELERKVEEKTLALSYSLMREENRRSMLQSLL
SFSHDLQAHNNIIEIVMTQVVALYPTAGWAMKAYTHNNEAWACENIDKDCLENNNIQPET
HYSDYYCLPKNDEYLHCFKVKNSHNEVVGVIVMQYEKLQRDDFEVISLFIRQLSTELEGR
LLNSELARIAVTDSLTGIANRKAFDHDLEQHIQLYNRYPERCFGLFMLDVNGLKRANDNY
GHNMGDALLIQTSKLLVEACRLTDKVYRLGGDEFAILLEGGDDDSCGILWQRLETVRKNI
NYASLPNGQCVEIHFAMGYASCEHHLTDQLCSIADKAMYKDKRSFYKQRGIQR
>A0A653KMI5|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MLNKLGSNLLLIAAVTCAPLLLLQGIWLAAQATPLTLTLILGTSLLGFGLLFMLAYRARN
AERAQQDRVWIKALQLRDPAVLETAEAQAALQQLLSHFNEADLDAHRQIDELHNLATQDE
LTQLQNRHAFRRDMTALLQRDQDTQSATLVLIRATELGKLNAQRGFQSGDAYIKDIANLI
TRVVSRFPGHQVYRISGADFAVLVQPVANIPPPLLGRDLKIAFDHYQQQHELESAAYSGL
TRLSSGQKIEAILARADLALARAQTETVNGWAIQQDDDEVVDLQGQHHWKLVLNELLDQE
RISFTYQPIQPMHRSMLAYNEIYTRFSSADGTVLPTDTLFAMAQRLDMVMKLEQMLVVHI
MRQYRAFGANQSRWGINLSSNLLQNSTFLIWLDRQLLKDPNTSANLVFELDEEHLERNMT
GAKRVFELLRRNGSRSAICNFGKGIGSFNLFRELKPDYIKLDPALITGLEQDLTNQQFVR
MIVDVSHRMGCQVIAEGVEQLGQKQLLQGMYVDGLQGYLIARPQPLRPDISQLGLFTEDV
STSAESE
>A0A5C5WF48|diguanylate cyclase|EC 2.7.7.65|Botrimarina hoheduenensis|TrEMBL
MDPLSLAAHPPRPIPLALLLPTGAIAWANEVFTQLPTASQVRLCQAIPLTRVLEPFALPP
ENGWSFRAEPIHTPGVRAPDLRLTECGTLWLLCGLPVVSRATLAESNDPVTGLAPRAVMD
ECLAEWTGPNGPACFALVFIDVDDFKGVNDRFGHQQGDATLREIAQRLQATVRSDDVVAR
FGGDEFVLLLRGIEPGGGWRKLKKRLIARLNEPFETEGNAYHSPGSLGVAFFNRSDPRTA
TELIAVADRAMYADKPAR
>A0A1Y6MH58|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MRNNWMNSLSLNQRLYLPLVFFIVVLFIVFQTLSSYKYIESEKQNLVNRITILSTGIGAN
LTAAIQFDDAITGQEILSAFSADPMLVSVSVLTAANTVFADFNNTDKLHTQANNTEQLTL
KKQGYVFSKQHLYMLVPIYMDEKELAKMSIVVSLDGLHALKWSQLEISLYLLVILVLLSS
FVIHRLRHWMISPIRQLNDAMINVIHFNQTEMVQQQANSKDEISALIDYFNTMISKLNQR
ESKIKHTIFQLEYEKAFADDVISTVQHALLVVDHAGHIILANDSCSKLFHDSPPALQSKH
ICDVINPSDPELFQQSLQNALLGNKQFSNDLIKAKNANGTAIYQVVSHPLSHKHQTLFAL
EDVTEKSLAERQQHLAAKIFENSREAILLLNRHGHIEMVNQTFCNLIGQKRTQIIGKYYR
SVLTETDNLPMKKEILMALALDQQWQGECSFYNRKRKISTPLHLKINKIIDSETNDSQIV
VLASDISSVKEAQRLAYIAQHDALTHLPNREFLHHYLVEKLALPRTYVMAVLFIDLDGFK
FVNDSYGHEIGDHVLQIVAKKLMKSVRQNDIVTRLAGDEFVAVLNPVKNREPVINVGERI
IASISQPIKIKDHTIHVGASIGFYYIEPTNVTGIDSVLHCADMAMYQSKMQGKGRITEFN
QIEEIECG
>A0A0H5NPJ3|diguanylate cyclase|EC 2.7.7.65|Nocardia farcinica|TrEMBL
MGEEQTNDAVDAEQLAQRYRALVEHTPDGICVHEHGVIVYVNHATARLLGARTADDLVGR
PLTDFVHPESVPGMLERIGKLTTAGAASQPTEMELVRVDGGTVPVETVSVLTPWHDHYAY
QVVIHDLTAQRAAEDAQRRAEQHFTAVVEQLEEGVVVIARGGVIESANPAALRIFGADER
YGDLVGYSIDDLPLTLLDANGKPLPVTRHPMARTLATGEAFTGYVFGIDRRDGQRRWLSG
SSRLLNPGDPYSPAVSSFSDITEFRASRRQLEYQATHDSLTGLANRSLILSQLAGALAAS
DDLPVATVLFIDLDGFKSINDTLGHAIGDTVLQIVAQRLQRALRSEDLVGRLGGDEFLVL
LANGPGPLDLDALVARLRATMAEPIVARGHRIQVRASIGVTELEPGDNRTPEAVLHDADV
AMYRAKPPGHRDSAVADSSHVS
>A0A381GGC3|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MARHNRKLSFTTPILVSFTGIILSFLLIAIFITFTQKNDFLEDYHGINRNFTHNLAVNYT
ESLLRENDYILGRAATYFSRNDHLNDTVNLDPEQGLKTIMQLQTLMPSVSSISLVDIEGH
YLRAPQVLNTERSTTFDVKSRPWFMDQAEASTFSNYTAPYIDYFTHHPTVTIYKPVISPE
GKMKGTIAFHLDLTSMGYALRQMVAPVQGEFYVVDRDGKVVLHPDTGALFKQYVSKKTMS
RMTSGEGHLYDPDTQDWYYYYSFTNPDWFVIYRVSDTTLVDLTRHETNIVVWGFALAAII
IALFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIESNKERELAYVRQATIDA
LTGCKNRRAFDSDIVALMNDHQPFVLALVDIDNFKFINDTWGHLNGDIVLRNVAREGIQI
MQPAAVSVYRYGGEEFAVLFSGEQLNNAHTLLERWRIEVAQRSWREEGLHVTFSAGLGEW
NLEAQEQLIMRVDEALYKAKQEGKNRIIVANR
>A0A4P7J3R1|diguanylate cyclase|EC 2.7.7.65|Citrobacter tructae|TrEMBL
MEQVAPVNNTLLLTEWQALLRQTSPDVHTLLTSLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFGWLRSVLGSAQEDLSQLLTKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKNKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHILGNSNLL
VEMEVLIAEIDSRLTQTLSNQQQPTEAARMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDRFGHITGDLTLKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDVSQASIILEGLRKKIADLRLGAQATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKNNGRNRLETYQE
>A0A5C5WRC4|diguanylate cyclase|EC 2.7.7.65|Rubripirellula amarantea|TrEMBL
MIWLDYFIPLSCGGGGVACGWVMNALSRQGAPPNVPRKTAAAELATESVPVETMEAKQKR
IAAVAEQLQSYAKTMAADVDAHQTRVKEVNHTLTNNQTQAPEAVLEAIHELIASNETMQN
QLQDAHDRIHEQALQIESAERRAETDALTRVANRAAFDKHLQSQHALGTGKAGSLAMLDV
DHFKKFNDVYGHRAGDEVLRVVAGMMHSRLNKHGLVARYGGEEFAIILDGKSLEEASLLV
ESARMAISQREILFEGKRLRVTASVGVAALESDESIEQWVQRADDGLYRSKEKGRDCGHS
MKRSKATLIQAKRISNLASPDQAPERESASIEAASIDLDDVFSLDDDEMIGGSEGEQASK
NSPPSDPSTSETVAAGPLASLPNHNALRETFEDILKRAQTSASMSIMAISCNGPANSTTM
RSLVQIVRATLRSVDRLGYENDSTLLVCMPSVDPSTAQARGLQICRSAGAVGIKQTDTGE
NMVSVGIAPAAEESDFEEIVRAAMDMSVRGRVPGMRPVVFADAVTTT
>A0A3T2V000|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPSQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATRGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A8H8Z6B6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPIMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFAHPLPIEIFEESYLE
EK
>A0A381C3F0|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MSDNLIERISTALESEYTLEGLVRQLLEMLELVTNMESTYLTRIEPDSSFQHILFARNTR
QMQIPEGLSVPWGDTLCKRALDEGKRYTSDVAKVWGDSQAAKALGITTYVSTPVTLADGS
LYGTLCAASSEHRILTDRSEQVLQLFAQLIAQQIQNEQLLQQLQQANAALTTASYTDELT
GLPNRRAVFEQLPKLFSQARDDARFVLLAFADLDDFKEINDIHGHEAGDDFLCEIGQRLQ
KGTRPDEIIGRVGGDEFIVAGFGPSNTDEAQHAAQAFKIRLSNLLTGEFQLHSSVINYAG
PSIGVVAVNPAEIDHDTALREADTAMYVEKAHRRAF
>A0A7H9I4Y5|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNKDFSQAPRPTFKNALRRISMISVVISMTLVWLLLSAASVITLKQYAQKNLELTAATMG
RSLEAALVFGDATAADDTLATLGRQGQFSEATLLDSHQRHFADWRNDALVKNEKFSGYIS
KWLFPEPTVQPIWHQGKIIGELRLKALDRLISHFLGTSLIVLTGSILLASVIALMLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVIGKLMDDDAARHSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGDQHQAWRLGGDEFAILLHDVHTETEVQALCATLSEQFLQPFNL
HNGHTATLSLSIGYALTWEHTSVEELQELADQNMYRMKNQRFHHTQK
>A0A8H8ZBU0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQKLQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A1V6DFZ4|diguanylate cyclase|EC 2.7.7.65|Chloroflexi bacterium ADurb.Bin120|TrEMBL
MDKDVYFGSGKTFIAPIKWCRYIVNVSYMTVALIIMAHLIWYFAARSVLVWPPDIYLRYY
IILPAIGLFALVIFTDLLVRFSRFSLLLKESLSLSLIIVISFYLCLTHNIAEVLLGSFIL
PIFVSTIFSNVKITRWVFWTSNFAVLLLGVIRYFTGKLNSDMVMQIFVASFMFLCSYLLA
KILIRYGHDNLAALTNFDNKQQYMQEQLKLDPFTGLFNRKTFDDYLPKLMEECRSTNKNL
SLALIDVDHFKYINDLYGHAAGDRVLLYFSQILKIIQTENILTFRMGGDEFSVVFRDCNV
EEAYSICEEIRNRMESCPMRAADEKRVTLCCGVVCMNPKDVDLEKFTKAADSALYAAKNN
GRNQIIIHHHT
>A0A3S4F499|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MPLKLNRLSHRLFAYIIACSLAIITIDLLSNSVVNRIPTTSSPLFPLLTIILMIFHITIS
CFMSMKYWCDKNRLYLMPIAFAFASSALLMLGTLSSYPGWLLCNSEYIVKQNDALIFYSF
RNILMAVLFITAIIIYRFRQHLNQAAGAHAIILTVCFLFSAAILILSWLHSSNSPLLSID
FIDDITSTFTPLWHNWMGWLLFLAWVCTLILLIMLTRLRNIFWYSGAFFCAAYIFTLNVL
LTATGSQHIIAWNQARLFETLSTLFMLFVLLSDVFLLYRDSNNKYINSYQNSIRDPLTGL
YNRSYFYDTLNGLLPHTSAAQPLSVIVSDLDHFKRINDNYGHVQGDKVIQFAASVLQTYV
RREDIAARIGGEEFALLLVNTDADDALAIAERIRQMVSAGQDSLPEQMTISMGVYTATSS
LIEAEECVKRADTAMYAAKNCGRNRVVVWQNK
>A0A6N3GGW1|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MEKRKKPTLERATWPTRHAMVMHGLAMNLPWLAFVNVSFAVMILLRHVLLKASDPLYPHI
PQLTTLVDASMLGIIILSAALILMAWRRIAGISVVLFICSAIWSVSCFLFITYLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPVASWILNDGLNLHFVIIWSVFTLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRRMEVVLENAVEQKKPFSL
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPLN
IAEKVAMRIQDGLRTEAIPHGASTVSDHVTVSMGIAGMTEGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A5E4TTX6|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MEFVTKDVLASCMALLLDAVFLVNRAGTLVYVSPACEPILGYAPQDLLGRSMIDFVAKED
RERTIEESKFVMAGLPRIGFENRYIHKDGHYVHIMWSARWSEDHELRIGVARDVSAKKQA
EALQRATYSISEAAHDAADIRSLCKAVHDTLSTLFPIEAIVVATCDAELSTWEKAYQYRD
SAAIPLLDWPQAQRLSTQATQAQGTLWHLIEAAPIDGAGQSIPHVCAEPLAPDTLVEPGK
QALAILSMHTARRAVGTLMLYGPAGALQAEAAQRLLAFVCDQTALAIERKQLIDDLYKAA
RFDELTGLPNRRTFGEFASEAVRRAQRTNAKLALLFADIDGFKGVNDSLGHAVGDLLLKE
IGQRMKSGVTGCGFVARHSGDEFVAIVQDAEVVERIDFAVTRLRAEIEQVISVNDASLSV
RVSVGVAVFPDDGESMSELIRVADQRMYANKSARKSGEASFLRRLI
>A0A0H5EXF6|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYNADEIIGQSFELF
YTPEDLATQLPAKGLLHANQLGHYENQGWRVRKNGKRFWGHITLSALHDSDHNLQGFVQI
TRDLTDKWLRENALRKSEELFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAIVMLDPWGRVNTWNHGAERN
MGYASNEIIGQHFGGFFLPEDIAAGLPEKLLKTSASASRVEREGWLVRKDMTRYWAVAII
TVIHDNSGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEEVFILWSPLQDKNQLVAINQCLAEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAISQLGQDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCQHKPATEVLERVVADIASIQFHWHGQSYSFTASLGAVSL
NRQTETAAQAMRQADIACYAAKHAGRNRLSLSL
>A0A1V4VYW5|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MDTIIKTKKELINESVDDNDGNLVGAIKSIRDITKHKHEEQEIRQYRNHLEKLVIELRTT
NERLQQEITERKQIEEALRESEERYRQLVELSPDAIFLHSKDRLDFINEAAAKLIGAESP
EEAIGMPMIDLIEPDYREIVSEKWRLVQEEGKRVPSKEEKLIQFDGTVIDIEVMTAPLTF
QGKPKILAVVRDITERKQAEKALKESHDRFVTVLDSLDTGVYVIDIETHEIIFTNEYTRK
HLGAVEGEICWKSINAGQSGPCDFCTNNKLLTPEGEPTGLHIWEFQNTISGKWIECRNQA
IRWIDGRMVRLEIATDITERRLVKDLIEVERKELFTALQLTEERYQQIVETANEGIWIID
SNEEITFTNKKLNELFGYTNEEMIGRSIKSLMDDEYRYKIKREIEDGNSQSKITEAKYQR
KDGTELWVIISSSRLYDHDGCFIGDLGMLTDITLRKKTENALKESEEQLRLIIENSQDAI
AKIGKSGKFEYLSPSIKNITGYAPEERLERSAFELIHPDDLDRVMTTYETLIKLSSSGKA
EYRLRHADGHYIWLETTGNVLFNEYGEATGAIMIKRDITGRKLAEEKLREAHQQLKAVIE
FLPDQIFVVDKEKKIIAWNKAIEECTGISKAEVLGKDDSTFAVKIYGESRPLLIDLTFID
SQEIELEHISRYNNFKIIDNVLHGETFIQSLFNGRGAHIWITAAPLYDSKGNQVGAIETT
RDITERKQMEEKLKYLSLHDSLTGLYNRAYFDEEMLRLGGGRYLPLGFIVCDVDGLKLVN
DTMGHKSGNNLLVKAANIIKSCFRSGDMIARIGGDEFVVLLPCAEKRTVENACRRLQEAI
ENHNKTNSELPLSLSIGFAVSNDTHTKSPNELFIEADLNMYREKLSHNQSTRSIIVKTLS
KTLEVRDFTTEGHAERMQKLVVRLATACGLPDYRLNDISLFALFHDLGKIGVPDRILFKP
SSLTENEYLEMIKHCEIGYSIANSVPDLIPIADWILKHHEWINGGGYPLGLRGEEIPLEC
RILAVVDAYDAMTSDRPYRKAMNQGEAIAELRRCSGTQFDPHIVQNFLEMLETG
>A0A5E9H785|diguanylate cyclase|EC 2.7.7.65|Carnobacterium divergens|TrEMBL
MFTIFKVIISDFSILITASYLFSKLTKKGVNSELKFFKKIQFGIYSGITGILLLVFSIFF
NNEFMIDLRLVPIVICSFWVGGISPFVASVIIGSGRYFYDFSDKGFRFFILYLLIGISQI
FISHLFKEYSPAKRLFLIFATIQIPVILNFLSYSGNSWANWLLILASVSYNTIGIILNNQ
FLKDMEDRKVSYQKLEKASTIDYLTKIPNRFSFDNQLKKDLSEQESTILFLLDINNFKKI
NDLYGHATGDEVLIHFSAILNEHPQINSRIYRLGGDEFAILLPKRDLHASIEDFRFLIKS
LIQENPYVEEGYELIPLSTSVGIGVSDVESNSGLLYISADKDLYHDKAQHKI
>A0A1C3JGN8|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MPHTTDPLTGLKRRTLPLVVFLVSFLITVLCFMLVALNQNRALNMNLDSFATHQTLSLEA
FIANDVAYIGSGANFFYANDPENWDKFDRFAQQTINESKSLIGLQWMQKVPADEIAEHTA
KMKEKYPSYELFTIPKHEAKTFGYILDGEPAFIASDLYPNTQANDNVLGFYSSRERFKLV
LDNIRQTRKANISDKVRLLQDGLDQDTPKTGMLVYHPVFEGESDNLLGVVIGVVRTTYYF
ENLLASAVGDMDVYIRVTDTGFEAEDSPILFETEGYEAVSGHHITKTIELTNRDWKVDYK
IDSCISFYGYLVLTGIVLVGTTISLLLAYIVNMQIREKERLYQMLDKRTEELRFLANHDS
LTEVYNRRAFNKMLDKAIQRNEPFSLIGFDVDMFKGINDEFGHPAGDALLIHVIKLIAVS
LKEGDNLFRIGGDEFCIISSITNHEALDRYLQCILSTVSHSHCEHKGRQLSCTLSIGAAI
RANENTEEILQKTDSMLYQSKSNGRNRVTIAG
>A0A1C3JJ32|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MSSINFESTYGVITIQDMNVVSVDANYARIYGYQSPEELVSNIDSFLDLISEDYHVLAYQ
NYLETVSGQRDPQVHTYTNVDRNGREFTVFSIDHVTEWQGRPALQVTVIDLSPAIQLQKA
VLEQDKMYHDMIMQSGQGILVHRGFKPLMVNQSWVNMQGAASIEQVLELDSILELVPKQN
TDGISKHYHAIVSGELSGTSTVVENIGFDGVHRFFNIYDNAITWKGQPAVQVVLEDVTQK
VMLEKQLVHQANYDEMTDLLNRRAIYEWLREHMSSNSYLVCMLLDIDDFKSTNDTYGHMV
GDEVICALANITKRSAEKVGGVAGRWGGEEFIIFIPNASLETALQVSEEIRQQFNQVEFR
IDEQLRFNSSVSIGISDSRACEDGVTIDALVNLTDQSLYRAKANGKNCVDGDVVAL
>A0A446ZF06|diguanylate cyclase|EC 2.7.7.65|Acinetobacter calcoaceticus|TrEMBL
MSGLRSEHISNRLFFFMLVIILSLLFMAIPLIVGSYQDYIKTRQALAEIKSLRAVADIAY
KISKERAPANKMMSSRPDNLLKNQQELKKFRLIVDAQIDTSILILKQAGYISLANELQTN
FKENLKQARRVVDYYGETSYEARTSVQMDNAILGMFGVWDNCREILQKLMLQLKSKDSRI
SNYFTLIIVLTDMRDQAGRMASNIIAPVSFNEEIPSNNRARSLQTQHQSKYLWILVDTLQ
PEQAKTPKYRRLYSQVKSEFIDKGIPIVEKLLEESQKGEPYYLNGTQLTEAIVGKFTTVV
DLQSYILDESVVIASQENVIARNGFLLTLLISLISLATALLTLNYAQRRVFSPLIKARTL
ILDLSHSSNHWTDEMNVTTKGEFLSLFEAIDRLQRMLQQRDAFEFQLKNIANTDPLTGVS
NRLALSEYLKIVESYPQKFTQTCLMIIDIDRFKQVNDQYGHIVGDHVIVSIAEQLKQNIR
SSDLIIRYGGDEFLILLEQVQFVDARLLAEKIRNAISLEEIDLSGSDEKLHVSVSIGFAI
GATSWIELLEKADRSLLKAKARGRNVVEG
>A0A011NZ01|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MLHWADDAAGADAQAAAGLSRWKVLVIDDDPEVHTVTRFSLQDLRVFGRPLDLLHASSAA
AARALLRGNLDVAVVLLDVVMETAQAGLELVGFIRDELGLAECRLILRTGEPGYAPELTV
IQEYDINDYRTKGELTHTRLITTVSSALRSYQQLHALAEHRRGLELIVRAAADLMQEHAI
ANLAEGVLTQLAALLRLPVDGIVCSQKGSPLGDDRERCYVVGATGRHAGCIAQPLEMLAD
QRIVAAIVSSVARRRHLFGPDYAVLYLQAAPSQEAAIFLEGGQMLETIDRTLLDVFVANI
AACFRNVRLVERLLRAQEEIEAQRSFLRSVIDASPHFIFVIDRAGRIRLANQSLAKRFGQ
TPEQMVGRAQADFVSDPQLLQMLRSDDEAIAACRQERIEREVSFIGRSGEERWFHTIKVP
LKDASGAVEQLIGVSIDVTDRKRAERRLLEARERVQVTLDSIGDAVITTDALGRIDYMNP
VAESLTGWTVAEARGRPAGEVFRVVHEETRVAVIDPIQRCLQETGIISLPGPCVLLARDG
REHDINDSAAPIHRGGGALQGVVLVFHNVTETRQLARQLAHDATHDALTGLINRAEFERR
LARAVSSAQDGGARHVLCYIDLDQFKVVNDTAGHAAGDELLKQIKALLAGTFRESDTLAR
IGGDEFALLQENCPLERGHAVAHAALRTICQHSFSWEGRSYQVGASIGLVAITAETQDTA
ELLTRADVACYTAKELGRNRVHVYQPTDTETVQRHSELLGAAGLRDALERGLFRLHYQPI
VGLAGPEFRILRYEALLRVVHDAGPGRKGELVLPAAFIPAAERFGLMGAIDRWVIRRAFQ
EYAQGIGTTGATLAINLSGNSLSDESLLQFIEIQLAEFSFPAERACFEITETAAIQNLRP
ALGVMAALKRHGCQLALDDFGSGLSSFHYLKTLPVDFLKIDGSFVKDICSSARDEALVAA
INQMSHALGLRTVAEYVESRAIVDRLIDLGVDYAQGYFFGKPAPWGEGGG
>A0A128FA94|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MTVTSIDVLDSVVDITAQTESDTISESLITTVLQLTPANQVLVLDYNSEATPEFMVVACS
DIFLYEDERDAIERVIKNCVLIGENIVEYSNDDNQALLAVPVRCGEKGEIEAVVFCKADE
LKGDEVQLIEGLTKIYENYQKIISASERDGLTGLYNRKVLTSKIDLLLDRFLIQGDTILD
CPSSTHWVCLFDVDQLKIINDSLGHVYGDEILLLITAIMKQVFSEDDILFRYGGDEFVVI
MHPQSREEMESTVRRFMQAVHERDYGQAKDVAISLGAAAISEDEMNAITVIGYADQALYK
AKQNGRSQLAFYEDLIASGELQSFVPEDDVEMF
>A0A4P7TT61|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A564FWM1|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MRQLRTRSWILLGVLAPLGMLAVSGLMLLELRRETWAKAEQTSRNLLQVIDSDIVRTIAV
VDRSLLAVIANLDAPGIEDIAPDLRQRLLFGPAATADHLAGMAVLDENGDSVFDADAVPA
RRVNNADRAYFRAHKADPDLGLHISEPIVSRVTGTPVIVLSRRIQKPDGSFGGIALGILR
LSYFTRLFDRIELGGLGAIKLYRRDGVRILRHPEAGPGSAGAATFARFGGAESGGFVARS
GWDGVERQHTFTRVGGLPLVLDVALATREIEAGWRAKALVIGAVVLALCGLAIGLCLLFG
RELGRSAAMQAELTRLSRTDPLTGLANRRRFEEAFDEAWDRAARADGGPLSLLIVDADHF
KRINDRHGHAAGDAVLRSLARALAASIHRPADLVARVGGEEFAVLLPATDAEGAARVAET
IRRTASRLPAGAPGIPAVTVSIGLATGRPGVGAAADLYRRADAALYEAKATGRNRTCSAP
AQTEPAGARGILSLVGAA
>B2U0I1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINNREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYKVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGPGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>B2U0Y8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAA
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRQEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTNRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLI
PRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAK
NDGRNRVLAA
>A0A564G518|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MPHRTATGIKRAAEDSFSLFDAEEAIIGRTDVMLARLSEVAEGVQELAGAYRRGTREQRR
LVRMSDRMQFELQRVNQRMAEQQRELQTLNEALSGEIEHRTRLEAELRRLADTDHLTGSL
TRRRLLEIGERIWARGPACLLMLDLDHFKHVNDGHGHAAGDAALVVFAAVCRASLRPCDA
FGRMGGEEFAAFLPETDAAAGRALAETLRRAVAEAPVPLERGSLSISVSIGLAASRAGEP
LAVALRRADAALYEAKTVGRNRVSSPETDGA
>G9Z6T9|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei ATCC 43003|TrEMBL
MMQSYVARVREEWLELLRDTDSDVQASAKALADAHARALSEVFYQRMLADPQAEEFLSND
QVETRLKKSLALWIQRVLACKADEVDALIALQQHVGEIHARIGIPIQLVDMGARVIKKNL
IPIIIAEGGREDEKMKLLSFTLCSIDLAMEIMSRTFTFGESSSLKDDENYRIFSLLENAE
EEKERQIGSLLSWEMDVMYKVMLDSELGSTPPISRADFGMWFTHKGRHYFSGIAEVGYIA
KLIQETDELFSRFRDPSRTAKQKHQRTELLLQMKSNTAQINTLLRGLFDDVAKHEVGMDV
LTKLLNRRFLAAIFKREIAHANRSGTPLSVLLIDVDKFKEINDGYGHAAGDEILRKISQV
FYDNVRSSDFVFRYGGDEFLIVLTEANQTETLRIAERIRSKASRQSITTPDGKLLATTLS
IGAAMFDGHPDYERLVQSADAALYRSKRQGRNRIEMYILGDTPYS
>A0A8G1HXP0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. ERGC3:05|TrEMBL
MIKASLRSHLTLWFAGLSLLTLLSVGFYVGQIATEQMKQASGNTLLSTARSTAALLAVQL
RERQLEVSLLSKAPIMRRGNLDAPDILTLMELRTQSRAEYAWMGVADADGRVRQAVNGLL
VNQSVQQRPWFQAGMHAEYTGDPHEAVLLAKLLPGAANGEPLRFIDFAAPIRNADGETIG
VLGAHAHWSWVTQIVDSAVMQKDAIPDIEALIVDVDGKVLYPELLAGEHMPPDSLLTTSG
WSTGNGYVTASVAVPSPTNAKMTWYIMVRQPLDVALQPAHTLLYKLLLLGLLAAIIFVLA
AYYIASSLSRPIERLAKSAKQVQDQQPGAVFPQEHSVLEIAQLGRSISSMTQSLLAKERE
LQEANASLEATVAQRTADLTQANADLLSLATHDALTGVYNRRRFDEKLAENSLLFQRTGR
TFALLLIDADYFKRVNDTYGHAVGDDVLCQLATLIESNTRATDFVARYGGEEFAVLLPEV
EEPDSPDVVAEKIRAAVAAAKFPTVGDVTVSIGVSIAQPSDRDSLALLKRADMQLYEAKA
AGRNRVV
>A0A7L8QG31|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSVMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVDDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A8B4G0I2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNKDFSQTSRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIGLLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQDLCQALSEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQILK
>A0A8G2AFJ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MHSFKAHVMTFAACIVFTLMIIFLSWIYSSHSPWLSIRFIDDLSHTFTPLWRSIIGWLLM
AVWFIALILIIWFSKLRNIFWYSGAFFCSAYLFTIFQLLSAVGELDQAWYQARFFETLCT
LFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVKAQHPL
SVIICDLDHFKRINDNYGHIAGDKVIQFAASVLDSHSRKDDAAARIGGEEFALLLVNTAE
DEAQAIAERVRLAVSAEQTPLPERMTISMGVYTTHDGSVTAEECVQRADEAMYEAKNSGR
NRVVIWRRQGR
>A0A5Q9LGC5|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLEQYQQLQRSDKSIELRLARLKDNGASREELALLHDGLQIAAELQD
EQQAALAHVANGDAPAAIAILYGKAYETELERMQTQIDRFRQMLENRAAVAIDQATDRSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEEHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAEAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTG
>A0A080M2Y9|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MPSLSNPSEIARETLRLLAARRISPSPENYRDIYNEIAGTSGNLAEAFPKRELQALQTAL
PRETAVQQKLVKRFEQAFKGKNWDEFRDGVADLVKQLANEHELPWSELFRDFLRQWENKH
AGLTVARKREALERVLAAAAGNSELLFGRLQGLVRSWSGSGPADGEIPLVESGTNTETET
SLPLAAEAGADSSPRTNELSGELRDIFAYTLEVIIETQLADEPELAADARMLVHKTRSAT
SSAALQGLLAGVKRFAFRLEILAEDRTELRAGLLNLLQLLIKNVGELVTEDRWLAGQIEI
VRDIVSNPLSIRAIGDAESRLKEVIFKQSQLKRSLNEAKESLKQMLAGFVDHLAEFADST
SDYHDKLELCAHRISMAEDISQLEDVLADVIHETRIIQLNAQRSRDDLRTAKQRVSEAET
RIGELELELDRASMLVRHDQLTGTLNRRGLDEAFDKEVARAQRRQAILCVALLDIDNFKK
LNDTLGHDAGDAALIHLATVIRETMRPQDTVARFGGEEFIIILPDTSVEDAQTAIVRLQR
ELTRRIFLHNNDRRLITFSAGVTHLQPGDTQGSVTKRADEAMYAAKQAGKNRVMIG
>A0A7Z7RHI0|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MSNSLLIMVSLAVASIGLITWQHSVRSDLIRARRRWLQASLLLAAGMLVEGYVEPGKGEM
LRLALGSGMSNAGIALQLTIIARVTGLKPPNWLWLAVGLVSTLDKLLPYRPLMLALESAE
IPLLYLAAAWLYQRAERLVSRNRFSPTALLFLLGALLFVWRDASDFYLRLQTSAAPDSLD
QLHQLALAFAAAAQVCGAVGFLNIVLQRQHNRLEDAANFDPLTGAGNRRALQYWLRTLEA
SVERVCVVMLDIDHFKSVNDRYGHPAGDAVLQVLAAVLRGGIRDNDMLIRYGGEEFCLLM
PDADIEDGMLATERLLQAFRQLAPLPKQPELRCAFSAGVHEWHCRQQDFADAQQKADQAL
YLAKQSGRDQVRRL
>A0A483K7J9|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MEKPLRLKLKKLYHLTRPAHVVNICFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLSQRHQETWRVALPNRRTL
PVFGVSEGVVRDHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTYYSRAISALWFTRQTQRNNPHRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMQGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEEAMAVASDCQR
SGRPLAVIQLDLDHFKGINDRYGHQAGDRVLSMVASTLAGTVRDGDLLGRVGGEEFCVVL
PNTTLQEAAAVAERLRLRIHGREVFLHNNVTLRVSASLGVSGSEERGEYHFEALQSVADG
RLYLAKQNGRNQVWYRSEA
>A0A8B4FML4|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MMCRSAPGVGRFGACMLLKELAVFDVLSTPIWVVHPFTECVVYANQASRTLSGDMSLNEM
RNGIYSTCPETQLQHYLRYLDAMTEIFEVWTLQTAKGLQSVYCKTTLVETEDSGTLLLFE
AVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPQKEGRIVDANIAALRFYH
YSDEEMRTKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGSLRHVQTYAGPVV
LYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFYRLVDAPSFIAHGFCLLL
IDIDHFKSINDIHGHQKGDEVLLVISRILETSVDREDKIYRWGGEEFLLFLPHSPIARAL
MVAEAIRQAVSEYQTLSVTVSIGVAEHHDGEAIDQLFYRVDKALYAAKNDGRNRVTRIPF
DSAELLRNSGGAA
>A0A380WHT7|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MPVSLKKLSPGAWLQLAGWTVFGTLGCIAVSLAATYAVFRNASADVLHLGLIEATVLPIL
LAGPLFFYLTLKLRELAIVNHKLVVAASTDALTACLNRGAFSTRVENVLTREIARRQRAM
GALLVIDADHFKSVNDRFGHAEGDEALRIIVAAIQPCLRRDDMLGRLGGEEFAVFLPGVT
PVNAADIAERIRRSVADAPFRPGGNNHTLTVSVGGALFDRPVMFEELFRVADLHLYEAKG
AGRNRVELAAMPSDMTPSWFHTGLPN
>A0A380WGC1|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MLTATGELPAKANTEPQLAIALIVAGIVFLASFFGILTRPVGFLAAVWPANAILLGMMVR
NPAFATPLGWLAAFVGYIAADLSTGGNFFVTLWLTIANMTGALTGYLLFRLAPESDRWLQ
RPASVLHLFAICCAVALAASIAGGGAARLLFGRDFFHGLTFWFITELVNSLIILPVLLTF
PGFRKLRELWPAKLSPALLQHALPMLVLAASVALAIMLGGPGALAMPIPALLWCSLTYRT
FTTSVLTMLLCTWLLISIPANFIPLPELPDPLRSLDSLRLGIALMALCPLTVASINAART
ELIERLSHAANHDSLTGALSRGAFIDRSETCLRINQDRGTSLLMLDIDHFKNVNDRFGHA
GGDAMLKEFVVLVSHVLRPADLFGRMGGEEFAVVLPGLDMIAATSVAERIRQALEARAIK
MPTGGEVWATVSIGVATRAPGGWTSFDEVMLAADRALYEAKDAGRNMVRVGAQQAYAAAP
TLN
>A0A0M6YAN1|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MIRKPISRITSVLIGLRDGTSLRQQIALLAASLCILSIAVAAFGAALIARGEAIRENRWD
LTLIARSMAQRLDQTMFDRYREVRNVADMELLKPVWTRNPDIIRETLDQLQRSLPQYAWI
GFASVDGTVVAATKGMLEGASVAERPWFVSGLKGPAVEDVHLAKLLDHLLRTSPDEAPFR
FVDVAMPVKDENGKLAGVLGAHMSWSWAEETRRDVLENNLGKEGLDLFVLARDGTVLVGE
DAEGTSLSRETAAYDPGNPDMVVAEVETSGLGDYPGLGWKVAVQQPVSVVSARVAALVRN
IFLIGFAVACLSALLAWLASRTISQPLLGLVTALDRIGRDEKETTVPRLHGFRELSQVSA
SVRSLLRRLGTVEESARTARDMLAVLKDEYSRNIRSSEERNRQLGADIRSLRTLAEHDSL
SGLLNRRAFQPFAEDAFATFQRHDRLFSVLMIDADHFKTVNDQFGHRAGDDVIRAIGDAI
VEEIRSTDKAARFGGEEFVLLLRENDANGAWVLAERIRLRIAALTMDAGVGNISVTVSIG
LAEVTADDRDVEDTIARADQALYIAKSSGRNRVCVDYPTPRSQSA
>A0A1J5SYQ3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDAPAPRRIYRLFDFVPHAVSAIAVATGVLVIIGWIFDLSPFKSALPGLVAMKANTAVGF
ILSGVALWGFETGIPGRPLRTIAQACAGLVLLLGIGTLVEYLSGIDLGIDQLLIEEVTHL
PGDIPGRMALNTVLSFIGLGTALLLLSTGQGGRVVPIHALAMAPLILGGSSVIGYGYDIE
DFLRERLNYTPMSIHAATIFVLLAVGILNARADYPLRRFAAGNTPAGVMVRRLLPAAIAF
TLATGWLIQQGYRAGYFGETFLLALFTATSIAGLAALILAIAGKLYDTAMLRERAEQALR
ENEEQLNTIISILPTGLWVLDAEGKVTFANPAAQRIWADVRYVELGRLGEYKGWRTDNGN
PIGAHEWAGARAVEKGETCIEEEVEIESFDGAHKIILDSAVPLRRPDGSIRGAITINQDI
TERKRIADELRRSAKEIEDLYDHAPCGYHSLDENGTFTRINHTELAWLGLNRDEVIGKLK
FSDLLTSSSLQTFQENFPRFKQNGYVHDLEFELKRKDGSLLPVLLSATAIYDASGRYVMS
RSTLFDLTDRKKLERELEHQARTDMLTGLNNRRHFFELAEQELTRSRRHGKPFSLLMLDL
DNFKSVNDTYGHHIGDMALQKLSEVATRTLREIDILGRLGGEEFAGLLPETTGTQALEVA
ERLRQAVERAIVTLEDGSPLHVTVSIGLASLQTGDADVDTVLKRADAALYQAKHSGRNRV
CREATAPS
>A0A7L6YN59|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C16|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A1J5SB55|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLPTEDVAQYKQQDPAYMEPQIGSSNSPRFAPGPILVFAGFILATLLSGDMLFVYMRDGV
RLEAQRSITEVGTLKANQIDNWLDDHFTDAGMLSGNSDLLHEVQSWIRGGTRDDARRRQI
ANRFGEFLNLLHYEAVVLYDASGSVLLNTGEPVPDAQERGKEARAAAASCQHKFIDLHPY
QDGNRSIRLGFMSPLSAGETCFGAIYLVEDPARYLFPLIHYWPNENKTAETQLVRKDGDQ
VLFLDQLRYRTEPPMAFKLPLDTQQASAIALRGKQGLLENARNYRGKSVLAYATAISGTP
WMLVSKVDEDEAYRLVNRMERMAGAMVLLVFCLIGAWFWQWRRRVLAEARTAILNQRIIA
DGLRLEGEKRFRTIFELTSLPLVRNSLTGEFIEVNEAWCKLFGYSQEEVLSRHLSWQQLT
HPDDFEPSDSMLKKMIAGEMPDYKIEKRYLHKDGSVLWGIAQVKLVRDEKGEPAFTIGTI
QDITERKQAEKMISFMAYHDRLTGLPNRALLFDRLSQAMSQAKRDGKSVALLFADLDGFK
AVNDKYGHEAGDSVLKMAAQRFLACVREVDTVARFGGDEFAVILGNLDDPQQARGVAEKV
VQAFAQGLVLADGSECNVGASVGISIYPENGSAMDNLMTAADQAMYESKRIGKNTYTFYN
AKASPRNDSIWFKIDDSHLVGVEEIDEQHGNLVYMVNRLNDALKRDDSPETILLMFDELQ
VATQHHFDTESRYMANCHYPGREAHEAEHAQLLNQLQHFKAQFNEGRELLVLQSIKDWLL
EHITYSDKKMAAYLAQHGVT
>A0A1J5TN67|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MWESLQSSGYWQGELWNRRKNGEAYAEWLTISVILDADGKVKNYIAVFADITSSKITHDE
FEFLAHHDPLTNLPNRLLFNARLAHSLSRINRTGDNLAVLMIDLDGFKLINDQFGHQSGD
QVLEVVAERLVANTRGEDTVARLGGDEFIVLLEDIVGVDGAMDIANKLIQEISQPIILDT
NIMLVTASVGIALSSTINNKPKALVNLADDAMYKAKNAGKNTVVCAEAPPQSNLKLLETN
V
>A0A1J5Q722|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSVAVAVPVLAHGSVWGQLYLARREPLPYTSEEVELLEVFANLVAGALTRIDIASQVERL
VMADPLTGLPNRRAADSALAAALASGAVTSVVMCDVDSLKRINDEHGHERGDELLRSVGD
VVRRMRDALPGSTAVRLGGDEFCVITVGIPSADVRIVVETELALGGLPYGASLSYGIAST
EHTDPELTGRSLFRLADAAQYRAKRARQLRAPAVNRYGGITQLTVLDDGLAALDTLTRDA
RARDTVTHTADRLCAVAAALTESVGAMRWYVSACESQAHVLRLVRRGESTTRPDTVFLTD
AFGLDFTSCTNSSTARALDGGAFWVHVSDPDGHPHERHLLAATDATAVVAAGGPDASGRR
WLVELYFDSLHVDVEYIATPVRAVIAAAIVGLP
>A0A1J5TUY5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFSNLLHASRSSIQLKLFLSLTAIVALSLSAILASQVYLVQDYFVRQAEANLRSSNYLLS
RVLADPLFEKDLSLLQARLQEVQTKLPLCNFQLKDDIGTVVYKVGEVRARSDTEFDPNSL
DGCYNTIIPVVHENRLLGTVRMGVRTDDIAQARESLIQHSAFFALFWFAIFMLPFFVQIR
RLVHPLGDLSKAAQEIANGNLDYPTPEPVRGNDEISRLITSFQGMAQALVSNRNAQAASL
AALNNEKSTLDALLATMPVGVIFADRSHIRYCNNAFRQLCLLGPDEDLVGMKNDTMLLRL
GQIAAEADSFLKTLAEILETRKLIEPKYIALKDGRHLRLISNIVIAPESSGYLGRFWLFE
DVTEERKTLHMAELRAEHDALTLLYNRQRYDQDLPRLIAQAERDGSRLALLLFDLDNFKP
VNDLHGHAAGDIVLKKIAETLTLQLRRNEVLYRIGGDEFALLLVNASNDEIALLAERIVQ
TVHSLTFDFNGTTAKVGCSLGVARFPHDAITLQVLLQLADRAMYEAKQRGKNNWVMHHDT
TKH
>A0A5I4KJ49|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Aberdeen|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1W1H7P1|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MNRDLSEALALRYDNNQLVKNLHIEKKNTERLNEQLMSKNRELKSLTRIDPLTGLKNRRY
LFEVFTPENTRLMKDYLLDEKGTNRRFKQHASQNPLEPILTNNEDDMFDFHDKTNSINYG
YGIFMMDIDKFKRVNDTYGHDSGDMILRQFSTKLTDQVRSDDAVVRMGGEEFVVILKLAE
ERYIDRFAEKIRTSIEEYMFSITQGRKINITTSVGYVFYPFFSKFPMSMTFEQMISLSDK
ALYHAKENGRNMCVRVRCRERDSDNIETVKSVCSNLDRAVEKGNIFFEICPPCSSGAILK
KKKKSKGKLLNDKNCNEA
>A0A6N3HCH4|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MMKRNQRVLKTTPHPFLRLASLGLLSFIFTLFSLELTRFGTLLAPLWFPSALMMVAFYRH
AGKMWPGIAFTCSCGSVLATACLLSPHDINLWYTAINIVEAVTGAMLLRKLLPWYNPLQN
LNDWVRLAIGSAVLPPLVGGVLVCLLPGHDLLLQTFLLWVVSEAIGALALVPIGLLFKPH
YLLRHRNPQLLIETLLTLGVTLFLSWLALTWLPWPFTAVIVLLMWSAIRLPRMEAFLIFL
VTVMMVSWLMAANPLAETQPKAGAMLNAPWLPFLMMLLPANIMTMVMYAFRAERKHISES
EERFRNAMEYSAIGMALVGTEGQWLQVNKALCQFLGYSQDELRLMTFQQLTWPEDLNKDI
EQLDQLVRGDINNYSLEKRYYTRNGDLVWALLAVSVVRFPDGSPRYFIAQVEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWELEPDIISWDKRMFELYEVPSHVKPTWQLWYERIL
PEDRAETERIIRDSLMARIAFKLEFRIRVKEGIRHIRTLANRVLNRNGEVERLLGVNMDM
TEVKQLNEALYQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWSQEQALGQPL
LTVLRITFGDNGPAMENIHSGDMSRSAIEQDVVLHCRAGGSYDIHYSVTPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFETHLKRLLQTVQDLHQRHALVFID
LDRFKAVNDTAGHAAGDALLREISSLMLSMLRSTDILARLGGDEFGLLLPDCNVESARYI
AGRIVQAINEYPFMWEGRQHRIGASAGITLIDETNHQASEIMSQADIACYASKNNGRGVV
TVYEPEQGLMQQERSMMSLDEQWRMIKDNHLMMIARGVASPRVPEACNFWLLTLRLWTSE
GEVMEERAFRASLNESELIRALDRRVFHEFFRNHATAVAAKGLGVALPLSSAGLASDRLV
DELLELLERGPMPGRLLHLVINADVLTREGKTIVGNLKKLRHAGCRIILSQIGHDLEIFN
HITPHTADYILLDSELVNNVHGNLMDEMMVTIIQGHAQRLGLKSIAGPTNQPLMMDTLSG
IGVDLIYGDTISQAQPLDLMLNTSYFAIN
>A0A1C6DN17|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKSIKKYETIINEALRSALEYDTPEGQINEFISFFGKHIGSDRIYIFEDDEEHHVTNNTY
EWCAEGITPQIEHLQGVNMEVIDWWYDTFDEGKSVIISDVEELKGVHQVSYNMLKYQNVC
KVVVSPLRHKGQIKGFFGVDNPPAVDYNALTMFLDMIGTMLISLLKIRNTFQKEQYNASM
SSYSALSEIYLCMHLIDIKTGKYEQIKNAKHVEKECEELDQENFSKRVYTTMKYFCTEMY
LSSVLEFVDLSTLDRRLMETNTIVHEFIGTVSGWCRERFIKVDSDEKGRLWHVLYCVEVI
DEQKRREKKLLYLSETDSMTGINNRGSGERKITEFLEKKKGGLFCLLDCDKFKKINDTYG
HAVGDTVLIKLAAVLQRACRENDIVMRLGGDEFAMYLPGMPDKAQAESFFKRLFTQIDKI
SIPEMQGEKINVSLGASLCSDKDGATFDTLYHEADAAMYESKKIVGNHAIIYSDLPQAR
>A0A1C6FWF8|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNEDIIKLKQENERLSRMAEIDWLTGLYNRGTSELKINQLLEKTSMGILFVIDVNHFKQV
NDRYGHIAGDHLLQEIARILGFMVLRKDLLGRIGGDEFVVYMPIERDKHFAEDRSRQIKE
RLADIPLADAKTKLSVSIGWAVFQEGDDYQTLFDRADQRLLKEKRARDRKSSGDFKAVNN
GIDMDIKRIRAELSEHDLIQGAYCQDYDTFKSIYRFVERRMQRVQSSAYIILFTLTDDEG
AFPSLRERECQMMILSEKIQDNLRATDVYTQYTSGQFLVMVSDVTADLAEMIAKRIQGAF
YRDFDEKKEHILLHHCYPLTPVEPIMRIRNTEI
>A0A653PMP5|diguanylate cyclase|EC 2.7.7.65|Bacillus altitudinis|TrEMBL
MTHLTGSYNGWLVFLSVAVAAVASYSALQLASRVIQSSGAKKRVWLIIGAMIMGMGIWSM
HFIGMMAFHLRSGITYETPLLILSILASFIGSFIAFSICIQQQLSTRRLLISSITMGSAI
CSMHYLGLESMANVSISYDPVLFFLSFFIGALASFFSLHLFFRLHRSEKRREDQLLKIAG
ALMMGVAIAGMHYTGMASSTMFFHSDGQVAAGGSLEMSPFSLSIFIGLMTLIVQSLMIFG
AYIDHRIMSQSDQLKENEQRFQSLIKHNIDGIIVLSVDRKVISANDQGKHILKMCNSWIG
DDVSQYVMPTEMWEDFIYQSKKAITREAELKTADRFYYYHVTYIPVHVNHTLDSIYLVLK
DLTQQKIAEKEIHVMAHYDALTELPNRRHGINHLNDVLSAQEETKTSTAVLFLDLNRFKI
INDALGHNIGDLLLKAAANRLTKCLPDNGFIARIGGDEFLMIFPHLEHGTHKIEQLSKNI
IRQFERPFFIQNHQLITSISIGIATSPQNGKNGMELMRKADMAMYLSKKHKQSRYEFFTE
SMERLSEDRLNRELELRDAIQRKQFVLHYQPQISAKTRQMTGVEALLRMKAPDGSLKSPE
AFIELAEESGLIIDIGRWVIDTACQQAKLWYDKQLKIPVAVNLSAKQFNSEDLIDLIKLT
LKKYDLQPSLLELEVTESMTMDNIKQSKQVLTSLKQLGVRISIDDFGTGHSSLSYLKDLP
IHRLKIDKSFIEDILSDSKSEQITGAIIAMGHQLSLEVIAEGVETFAQAQLLSAQGCDDL
QGFYYAKPLPASDIEKFIAYPAHQLDT
>A0A0J1MD30|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. MGH105|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHMLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTGLEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDNRMTTTFSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMCMAASAAESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRIEVYQE
>A0A1Y6MFD0|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MATLIKSSQLQATNFAYIELSEKTLKKQLSLLFPFAGAICAVIAFTYLVSQQGHYFTLVG
ILGMALCYTLAALNRTLFSATILFWIFLIATTLVCSSGFYFTGARHISNTIGLTIPLLSF
FALQIRTATWYSSIFGMLYIVLSVSEIANKQMQISSALQNICAYSIIFVMAFLLSRHRYD
AIQQVKRTTTNDFLTGLLNREGLLPLYQNESSRCKRYRRDISMLLINIDKFRDVNDRFGL
DAGDKTLMMLAKCLREMCAENMHIARLSSQEFCIIIPDADIQRAEQFAVNIRDEIGQWVL
ELTTGHQINITVSIGITNVEYQDFSYDYIKAESALMRAKRWGYNQIATNE
>A0A090NMJ8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFR
RCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREI
RATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVDD
VWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPT
KQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPY
YGNSASVKLLTPTQDSRDIINAATRSLDAIWQVGHRYQKAGVMLGDFFSQGVAQLNLFDD
NAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRVK
>A0A378KU04|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MLIDNGINRQLNQRLIIECYKDHFFLILTDIAASVLFLTILWNSVTNRTILLLWFVLEII
INDVLRIGVLLVYHNQQKHSKPQNWKFWNFFYIATSAISGIFWALGGLLFVYVDDPVHRC
VIFLFIIAILSAPALKMIAIKYAYIAFEVPIGILLFLISTSITPSVSMELFIGVIIFLAL
LTYGAISAHKTLRTSILKTLENNLLIEELKLSEDNFRNIIENAPIGMAFLSLDGKYLDAN
RKVLDILGYSKEELKQLSYQQITHPDDLEDSLHAVHKLINGEISSVTVEKRYIHKNGNII
TAISSGTILNQSNDIKVFLTQIVDISDRVANEHKILALNNKTISTLNELTLLEKNEKLVN
KLNGMLQLCITMDETYPRINLIAQELFSGFNGALSVLNKTNNSLETVIQWGNDKILKNVF
SPEDCFSIREGSITIIDDPKSWVACSHYLTTPIGGYMVLPLFVQNELLGVIHLAAQSTIP
IPKHLQDTALTFSNMVKIALSNIKLRETLREQSLRDALTGLYNRRYINEYLPNELAKIMR
TKSTLIIIMMDLDDFKKFNDNYGHEAGDEVLKLIGQIINQNFRVSDTACRFGGEEFLITM
SHSELDTCIKRLKEFQKTIKSKSIFFNNQILPFVTISIGVAVAPMHGSTMDELIQAADHA
LYTAKKLGKDRVELYESPGSHS
>A0A8B4S567|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MPSNLQLYLLVAPVCIAALGALMAFCWLAQRRSVFLLSTACGLTLTGLALGWQCLTPHGQ
LVRWAVYTGPIYLLGAWLCTWGVAQKFSVSSYPKISALVSIIVVAALYEYSIVQDNIAAR
VLWLNTGLGIIHFIPFPAIALKKVRRDGLEKLLYRSYGAFAIYTVLRPIMVLFLGFTELQ
DMLSSIYWLVTMLGSLLFSLVFSGLMLIVSMRDAMATLRDERNHDMLTGVLNRRGFWEFA
DPLARDRKAQPISIVVADLDHFKRVNDSWGHEYGDGVLKAVAEVIQASVRGSDLVARFGG
EEFVLLLTHADIETAQCVAQRIRAGAVEIIAPLPDGQRVTLSMGIVVNTFGSDLREAVMR
ADQQLYKAKELGRDQVVVHGPGDVAAVA
>A0A8B4S4A2|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MSGNMRLSRLFFCTTLLLLGLVSLMMVRTMWTDWQDVRRAEFGLQAMELAYAAMKVAEHA
SAERGPAIPVLNDPPSDALRKRLAQFQQATDAAFEVALTRLRRREEAELSTALPVLERAR
TQMQTARQELERVAALPQAERAAIDKRSTRQVIDQMFEVVDTVLEAVTLLSASAERIHPS
LSLPLVGARYAAELREHAGRLGSQFTAPMASGSPLGPQERDGIPRLLGRIEQLKALLDVK
ARTSLSDPRIDAALQAQQERYFGQSLPFIAEITARGLAGKPYGMDSAQFVSRHVPGMRSI
VDLRDTLHEVGREQIQEEVAGAWRRLRVNALIGCCILVLEVSVFITLRRRVLSPLLIITR
HMMELMRGRLNRQLPAVQRSDEIGELQAAVHALQASLQRTQELEAERETLITELRQLSHR
DHLTGLMNRRAFDDQAPAQLAQAERHRWPLALILFDLDHFKRINDQYGHETGDQLLQHAA
QLAQTQLRRGDLLARYGGEEFIALLPDCDDQAALALTERLRQAMQQPLQRPDGSMLNLSA
SFGLAVQPAGLKSSLPELFSRADAALYTAKAKGRNQVQLAL
>A0A1S7RUH0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense Zutra 3/1|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSVGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDESILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDGEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISAVLGENDMVSRLGGDEFAIIQSANGDCES
DAAMLAARVVHAVSRSFSLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEPGMDMAAQHKHALEIDMKSALENQEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLIAPDRFIALAEENNFIKPLGEWVLAQACRDAMTWPKDIRLAVNLSAVQLSNDDIV
PIVDRALETSGFPAERLELEVTETVMLERDNSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPSNPMCSAIVNTVIDMAEQIGLKVTAEGVENREQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAPIAKDEFGDIGRPTQETYCPPQKAI
>A0A5I8HXY5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ouakam|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3AAW6|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MLRKRTSSNIILIAIVVVLVLLSVVSFVLYQNNTRNILAEKSKADMKKSTDQSIILTNSL
IDNYFSELDTIAIFCSVNTGINDHEIFELLQQKNLGNTYSQIGVAGLDGFIYTGSGSKQN
VSDQDYFQRAIKGERVVSNVITDANTGRDIIVLAIPIERNGVITGAACAQYDVQSFTDLL
SSSQFKGAGATMIMQKNGKMVSSYVGMEAFDTFYDALEQQMEFRGENTLESFKSRVKNEE
SGLFTYFRNNNERYVYFEPVGINDWTMISLVMAETIDKQTTAINAGAFVLMIFNILLYGV
ILAIVIAIIKRFGKQMEANQRDPLTRLYNKDIAHTIIERHLKKEGQKQRHACFFLDIDDF
KHINDTYGHQTGDDVLFSVAQILLHCFRETDIIARFGGDEFVVWIKDLPSADIVRQKAEM
LCNITAAGPNIPISLSIGIAWYPSDGTSYTEVMQHADEALYRTKHSGKGNYQFYSDLQ
>V0AC45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 909945-2|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7L6CIU3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00994|TrEMBL
MNRKFREIDATLRGLNYSTDAHFKWLVTILRFVANRDVELPEITHDDAHHRCEFGLWLNN
QLQDEQNDSHYLLDISAKHHQVHQTCRQIMASIERQEECPASYDAFEVALLAFTESLSHY
KAHLLQLRTSYDALTGLPLRRILDESFDRLNAGAEERGLYLLLLDIDHFKKVNDNYGHLT
GDAVLRSLALHLEDNVRRSESAYRYGGEEFIILLRANNDREAAAAAERLRHIIADAETVF
GGHTIRITFTSGLTRVHRGEPLREVLERADMALYRGKHGGRNCTMLINRNLDCINVST
>A0A098GCV3|diguanylate cyclase|EC 2.7.7.65|Tatlockia micdadei|TrEMBL
MIKEIVAPKEFNNGSSAALREMGRGRKLLSFNLLFIFAFIFIIFFYFFSYKQIDRLISAN
SWVIHSYEVIQATDNALYFIIDAETQQRGYFITGNKQFLIDRNNSLVSLRNTLKKLEKLI
QDNPLQMEKVKEFAALIERRIDLLTQLQQTKENNLANTQRSLGLIEFGQAMSNRIRSLAE
EIRTVELTLLTERNHAVLTSTKTEDVILVIGNLTSLVFLIIAFILFNRELKRRIHSEEKE
RDTESRLLSIIESEHDMVAAVDTEYRFIVFNDTYQIEFKRLFGILIRPGMSVHDALVNVP
EIREKFLSIWKVSLEGKGYTENMEFTHEQEKNIYEITSSAVINNKSQIIGAVQIIRNITK
RIQEQTKLQDYSEKLNQGMNELQNKNQQITLLVEMSDNLLACASQEELSTVVEQYCQRML
SFSSGFLYAMHPSKNFLEVMVKWGEPSEQDRVFYPDQCWAIRRGRLQYVSHSHLELLCNH
IKNKKNNTAYVCIPLMAQNDIYGLLFMEMQAEQEKQFVESTRLIVNAFSELTALALANVR
LRENLRYQSIRDPLTSLYNRRYLEDFLQKQIHQAERAKTNLVVLLLDLDHFKKINDTYGH
DAGDIVLKELGRLLQSDIRMGDIASRYGGEEFIIVFYDTPLNVAKKRAEQIRRAVSLLPI
KYGAQEVGPITISIGVSIYPQHGTNSASLIEAADKALYMAKNSGRNRVVVFGEKEISHIP
NPNKKSEG
>A0A857JDT8|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MTYLYAIFRHLFVYAALFILVVYFVEAQRPLLRDWFLPLPWIGYVALGVSAVIALQFGRS
RLFWCCVMLAILLLIGHEKIDLSSEFSRRLPLIVLMILSYLSCVKDSGFSGHNVAVTLVK
LFVVTVLSWAALTYLPALVQNHLSPMYTFANQIAPGLNAIYTPLEWLLVGLALVTCLLRF
IFVTDNNHAALLLGALLVAIMPAYSGFELHSVLTLVLATSFVYAMLKDSFNMAFKDELTG
VPSRRALMQYVNTLGRKYVVVMADIDHFKKFNDTYGHDVGDEVLKLVASRLNKIGGGGKA
FRFGGEEFIMIFPRKTPQQALPFVEQIRQLIADYPIALREKPRPKKAPKRGTGKPNQGKT
VKITASFGIAKRSSEFNQFSDIMKQADIALYTAKKAGRNCVQLAKQPE
>A0A5C6CBQ1|diguanylate cyclase|EC 2.7.7.65|Bythopirellula polymerisocia|TrEMBL
MENQLPKTIHFTSDLKMSIPQFPLPIRGICTGACIIDFAEDRVLATNDLIRQWIGSPIDP
ISNDQLFSLIPDLKSAMQELNGTSPRKSTSSNSYQINLHRNGQPVTQATVYLSSLESNQN
LWHLLLIQPNTQTNHLASYSDVVTGLPDRRVMEDWRQQWGYRNPGEPCPHALLFLDLNDF
KQINDKHGHANGDRILAILAERWQESLRDDDLVVRYGGDEFVVLLAGVQSIEEAIPVVDR
LRATAEEPLLVEGREFSVSVSIGIALANDLTVPMDDMLETADRNMYAQKQQAKPNKSRS
>A0A7H4MCL1|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNVCRKKIGQLAFNVGGDTQIPITASIGFAAHTGHPDYNLLLRDADNALYAAKRDGPQLR
EDAQRRGDKTAAPGKRSATWEGALKLRTAPAAPARASLHAASAA
>A0A177W0X9|diguanylate cyclase|EC 2.7.7.65|Piscirickettsiaceae bacterium NZ-RLO1|TrEMBL
MGQNIFTIIKPSLETQLLIYQTLYHQPNNQFNLADAFANFYQIIYQITPCAGVTYENQED
HIYLQQGTTGKYSYSVLLKHQNQPIGKLTFSHSLPFSLGSGLELDALCSLWLTPLFHILQ
YHSALQATRQDHLTQTGNRAAYEKILDQEINYAKRHDSPLSMLLIDIDHFKRINDQHGHQ
QGDLVLQHFSRLLKELVRDSDMIFRYGGEEFIVLLRNTDLAGANLLAKRVCESVYHTLTF
KMDINVTVSIGSCEFDHYDTDQQFFQRADQALYHAKHQGRNCVASYSIFDTSPKLLSTLS
EISQNIS
>A0A7Y8VH31|diguanylate cyclase|EC 2.7.7.65|Alteromonadaceae bacterium|TrEMBL
MPRFSSEHLCSEWLAINARFTADAQRFVIDFARQHAASLSEHFYREMLADPGASQFLSND
EVQNRLGQSMQRWVAGLFAPTTEEDVFRLIAEQRKIGEVHARIGIPVHLVLRGARCLKDR
FVHLLHHASELDENTRFAATRLASDTVDLAMEIMGHAYSVSHDRNSRAEEAYRLFAITQN
IANEKDQQRAALFDWENQLMFSQAIGTLPGELPRIQASDFGLWFRHKGIHAFEGSDEARA
VMDTMEEIDNVLLPLFGADEQSTALGTSRVDLLKDLRDKVKSIRFHLGNLFEQNNELEAG
RDVLTRLLNRKFMPVVLSKQISQARAQKSSFAVLAIDIDYFKQVNDTHGHQAGDQVLQQL
ALILVNNSRSGDYLFRLGGEEFLLIAVDMDPTRAKAMAEKLRNSVNREAFLLPDGKELQT
SISVGVACFDGHPDYQLLLRRADDALYSAKNSGRNRVVMATATDTALPANPPG
>A0A7L6UGV6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C17|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYHYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A7Z1Y218|diguanylate cyclase|EC 2.7.7.65|Pantoea vagans|TrEMBL
MTIEILSPQNNPPNRWLSALVLGCVVFVLTMFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIIIGPALANIKFALLNLIQASVGGMLLRALLDRRAPLNS
LHDWARMVVSVGIVTPLLGGVLAIWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRAQFSDLRLAESLLTLVLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFISMLLAFDLVNVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPQGNWLQVNRSLCQILGYPAEELKRLTFQQITHPDDLSL
DLEHATRLLEGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDSSYAPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWVHL
LHPADREYAALTVQQAIELRSAFHMEYRVVDAQGQRWVRTQANRQLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGLSQEQAAGQ
PLSELLHITQGRNGPEVENLLLCQLPAEKITPGLAEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHHLRSSDFLARLGGDEFALLMPDCEV
DQAHDVVQRIVAAVNDYRFQWLGRLYHVGASAGVTQISADNCQSGDVLSQADIACYNAKR
SGRGRLVIYEQHRLPLPGNHQGMDAAMIDALQIELPAWAVAPPKTPQAAFIWLLEVQLLT
ADGLLVDETLLRNNLPDDSLRRRLDNNILDTFFRHDVQRLNSKGIPVILPLNAQVLNDAV
FVQQLCQRFVAEGLSDSRCGFAFPAASVLSKGDQLYAALMQLRQCGCRVVLQHFGRNLDA
FNLLSDEVVDYLVLAPELVANVHNNLMDEMLLTIIQGQATQRNISVLAGPISVPAVLSTL
ATLDVDGVWGSAVAEHQPLRSLAEDRIFAIR
>A0A7L6UIX5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C17|TrEMBL
MDKDLSLTPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQRNLELTAATMT
HSLEAALVFADDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNALENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSHEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRAVRSIK
>A0A6N2V5W9|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKKRLLSNRVRNAILMAILLQSVIFGIGLMVTGTFSGTANRPYKVMESQVAEKDALISGY
MNNSLLIANTMEKELAKIKDDRKIHDRLIDNLNHASSVDGVFYLDLDKKEAVIYRDGEPQ
IFSSAYGDIYCVVGSSKSEYPIALSKDWSPKLTPEEWAKAELFWTDRTKGGKWFFDDNRL
YYVISQEVYGSRRMMGFQISGEVLDSYLSLDNPPYKGMEVLLMTDETILYSRDKAFIGTD
YDYRGDGSRISLTYNGASYDGVRSVLQVYGHMEGGSVYVGAVCYHSELAELSRSTIVMVA
GVYLLSIVIAIIFSYIAIWMVLKPIKKLHEDITCQNPEEVHFRESGIEEIDRIHQALNDM
AAKLEQSYSRYSFTLESAGEKVGSFEYQEGGSRVKLSSSILQLLDIGADRMGTDGCLDYD
VWEDILGGLDRVMELEDGFSYTDRMCNTRAVSIRQRHEEHGVFGIVMDKTDAYMEILRLR
NISQHDQLTGLYNASYLKKEGQKILDGNRSRVNALVFCDLDNLKFVNDNYGHEMGDHYLK
AMADLLTDIAFGEQCMAVRLSGDEFVLFFYGYSERKTIEDKVRSGYEGRSSIQLPDGTSR
RINASIGLAFAQRESESMEDLINRADRAMYRVKRTEKNGIAIYDKSDEAGPV
>A0A1W1I3K8|diguanylate cyclase|EC 2.7.7.65|Nitrospira japonica|TrEMBL
MIAVLLIEDNDVDAQFTQDLLAEWSIEEFRITHVKTLADGLALIGQTRFDAILLDLSLPD
AFGLPTVRQVHATNPAIPVVVLSGVSDQALALQAVQQGAQDYLVKGQGHPELLARAVRYA
IERKRTEERLTYLAQYDHLTGLVNRSLFRDRLIQAMARSKRLQQPIGLMLLDLDRFKAVN
DTLGHDIGDELLKAVSERLKSCVREVDTVARMGGDEFTIILEGVPSEASIVVVAKRIAEA
ISSAFELKGHHVSIGVSIGITVYPHDDQGIDELLKHSDEAMYRAKQQGGSGFYFHEASGY
HTQSAHAES
>A0A3Q9KIJ0|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MSSNKSALPVWASRADQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFY
STLLADAEAGPRLSHEIVSTRLHKGMKHWLLGLLCVRDQGDIVALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAERLRASDLDGTSASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALGQITEAVMRLDDVVLPRLMMDDRERQLSMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISISSRQGSRFSVLLLDIDHFKAINDA
HGHSGGDHVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTSEEAALAAAQKLGAEIRR
HDFTIPEVGALRITASIGVATFDGHPDYAYLIDRADKALYQAKLAGRDRSVLA
>A0A3S4MYJ8|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MHVDLYTLYLLVIGTLLASAGMLYWEYRTNTRRGKELGLLAVGFTTIAAGCTVVLLRGHL
PAALGPGLSNFIILSGYLLVLHGVAAFNGKQYRWTSAALLAMTALLWTAAGTRWQGIMWS
YVSAAPIAAVAALTAWEMWRCTPLKPLAPRRFVVAITGIHALFYAFRALILPWLVSAYGP
AVQLASSNITMYEGVLYSVLLPMALLKLVREEAHGQLLRESQTDYLTRLGNRRWFFEEGT
RLLHAHANQGPVAVLAFDLDHFKSINDRHGHQAGDQVLKGFADIAQNVAGPGVLLARIGG
EEFAALLTGDEARRAQALGEAVAQRFADTYSEQVDRSAIRATVSIGLARFEHNAPPLADS
LAAADRALYRAKSLGGNRLELA
>W9V001|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MRLSNPAKNLPKLHLLGTLLVVFTLTLMLGGLFLGQRFADQINFLNKLEDSVAQQIQDQL
QSEMITLRNYLDHTRAQSDEILRARLIEQVDLAYDLMNTIYQQERNIRNTQEIKKMIVES
LRELRFFDGRGYFFVDDMEGRFILLPTAPEFEGRLMPDNQDDTGHFIMQGLIEAARKPRG
EGFSQYRWYHPEHPSQMSDKLAYVRYFEPFDWLIGTGDYTYEWDKKQQEVAKNWIRSHRF
GQSGYITLFDISGQLLVSPGNVELEQTPPTQRSQIEQASLNQMVLTATDGGGFVDYWFEE
PSTKVLRKKQALVGVYEDWGWILATTIFEDDFNSLLSQERQAFSVAQARNYRQLLIGGSI
ALTLSVLASLVFSRWSRRLFRSYHETNQAQQRQLEKQAKELKEKEKQLRALAFFDPLTSL
PNRRSFMNTLSNRNDGRQSGAGYASLLFIDLDNFKPLNDSYGHDYGDLLLQQIADRLQEG
VDGNCFVARLGGDEFVVLVDDAGEDVQKAYTRTENVILSLQGDLADLYQLRDIQYPITIS
IGATVFCAGEKPVDALLKEADLAMYASKAKGRNGFTFFEPSQVQSNNEEI
>A0A377GCN0|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MRSLKNLLNRIGYADPMDRYARQYRLIWYISLELIAICLILIFLYSLMQLWHMVVLFSSG
ICIALINLWVLSRTANTFFCGHLITLIAFIIICLVNYMIWGIGTLHNQWFYIIPLLAAAL
VGRSGLIIYSILSFFMILGFSTFSLPPFYNLPYHKLEIIEWGNHLLAYLIVVTTLVNLLY
EHDKYERKLTDLNYLLQSEKDKYHYLARVDQLTNLPNRRYFNQYLQEVISSLSSNYCATL
FFIDLDNFKYVNDCYGHNIGDHLLLEASRRLKISFREGDFIARVGGDEFTAIVLHTIDDQ
IPQLIAQRIIQEFDREIKFGEIELNCPVSIGFATYPIDVHGVTDLMIKADRAMYAAKKIK
GSSYCKAEA
>A0A5P9CDL9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MAVVMDAEGNAVSELEELTLALLHSRAEVERLGEREQLFSSLLGSVNAVLWAFDWNEQRM
IYVSPAYERIFGRSAALLLADYGEWRNSIYPDDVDYAAESLAKVLETGAVESREYRIIRA
DGQLRWLSDKCFVSPRGRQQQGPVIVGIAEDITEKKRLEGELHRLATTDVLTQSSNRRHF
FECARREFEHARKFGSPLAFLLLDLDDFKKINDHYGHQTGDDVLRRLAHCGSNALRRGDL
FGRIGGEEFAALFPGCEPDVALQVAERLQREVQRLGFQHEGTSFRITVSQGLTSLLAADA
SLDALYARADAAMYLAKRQGKNQIVVG
>A0A2G4B346|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPVKAFAKQISATRDHRLLAESLFGYLVEVLAPKGIGVFAEPSPEGDSLPLFSCGELTSL
DKYPSTFWPWVSQFDTADGVLPMSINTCKWEHMEVLGGESFIMMLDNAPACRTYLIVQNC
NAQQINQTFDQDLDVLQLAAARWQCIRAEKNAALEIKHRDTREAQYLDEIKLRELFVENM
KLVHQVALELSNPDSLDALYKASVEAVRDRLGFDRAIFMLLDMKKRCFSGTYGTDERGKT
NSEHHTQYDLHQLEAEYIEALSDNHINLVIIEKAPLYTEGKVVGQGWNGMLILREGDKPV
GWIAMDNYIHRSPITNYQKQMLESFGSLLSQIYIRKRQEQNIRMLHSSMVELSRCDSVSE
VCKSAVSFAIQHLGIDRLAVFLTDKNCSYMQGTWGTDIKGDIVDESYYRSELVERDIVAA
ARACPNQVAFEESVPIYHDFNIVGVGWTAMTMLTTNMGEPIAFIAADNLLTRSPLTSQLR
EVIRIFASSLAEVLQRTMAQEELKKLNETLEQEVSKRTQELERANEQLDIISKLDPLTRL
GNRRMLSQVLDDLNCDDQGAFATEHEVTFGLILVDLDHFGLYNTVYGHTEGDAALRTIGK
ILNAHVHSDKETFCRIGGEEFMLLMIGTHHSETKQRAESIRKCIEEAKILHCESSTSQYL
TASVGYASITSDQRQFDFDLLYGKADKALYQAKDSGRNRIVSALKRRKVATPLI
>A0A550AKH9|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MKKILLIEDNPQLLKSKIEELRKNFSYSIDTVETFAQLQDYLTKNNENVFIALLDYFLDG
AMEGQSVDLLLEHKIPTIVYTQEYSTEIREVLLDKCVFEYLIKKPNTDLLYSTRLIERVY
KNDFIKALIVDGSESFRNKLAGSLQQFGLASLQSSDAKTTLELLKTHSDIQVVLIDLDIS
GDIQGVELVEDIREHFPSTMLGVLGMTPHGYNSQLSIEFLKKGANDFITKPFVKEQLNLR
IMQVLEMLDTIQEKNIEATIDPLTQLKNRRALEVESKVLIQSALIANSPLSVAMIDIDHF
KAVNDTFGHDVGDDVLKWISEILKSNFRKKDLIVRNGGEEFCVVLDDLSLEKAIDIFEKM
IRQIESKSYENDGVIINVTVSIGLFHGIKNDIKSMLSLADKKLYLAKKNGRNQLVL
>A0A447L0T3|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MGTRFITYSALKNLDGTLVNVHSLSEGMRGEYGRIISVLLIMWLVFSCALLLAYQVILRL
VRRMSDLQGNLAIRASYDTLTRLYNRGAFFEKAYAIVEKCRAINRPYSVIQIDLDHFKFV
NDCYGHLTGDRTLATTARLVLGAVRQHDVVGRVGGEEFCVILPGTTKSVASQIAERIRAS
LEGAMILTDDNLPIGVTASLGVACADEDGSTALNDLRMIADRRLYTAKKNGRNQVISDDT
PSTGA
>A0A649YRU3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MNSTFSAAVARNPDLMHAVFESLPEPTFLINKSGIYVEAWGGTDTKRHHNPASLIGLNQY
QVLPADKAVWFSQVIVDVIDNQKPAELSYSLDPKDLTCFEGIQGPAEIQYFSALVIPLPN
TEYVLWTVRNISEYQRALNKLAEQQNELERLTLIEHLTQVYNRYAMDALLPDSIELARLK
GMGAAVFMIDIDCFKEFNDHYGHIKGDEALKAVGSAIKQWAHNNDLCFRYGGDEFLVFVP
GISEHMCIQHAQDLLDAIAQLALEHRTSHVSQYLTITVGIRHCDPIPADMTAEKFVGIAD
KALFFAKKHQRGTIHKM
>A0A5E4Y863|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MPDAMPAVPSTSSAATTVAAATPPSVASDDAVMFDLAPVSLWLEDFSGVRQLFDQWKAQG
VTDLRAHFKTDPAHVSACSQRIRVIKVNRKTLSMFNAPSLDALIENLPRVFRDDMLKTHI
EELCQLWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEASLDRVLISLEDVTELEHAR
ERVTMGEQYARGLFEYSPVSLWVEDFSAIKLLLDDARARGITDFRTFTDVHPEFVERCMQ
EIHVLDVNRHTLAMFVATDKATLLSRLPDVFRDDMRHNFREQLVDLWENKLFQQREVVNY
ALDGNEINVHLQFAVLPGHEARWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSF
YVDELNRLERKGPYPVTVVVADLNGLKAVNDQLGHAAGDALLRRAGEVLGKSVTAPQIAA
RIGGDEFALLLPSTDATGGAAMMESIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEAT
VQKADLLMYEEKRNHYAGSLNERRTVDGLPSGTGPAGGVGGA
>A0A7W4XMN5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas umsongensis|TrEMBL
MYPLDPAPWVWVVMLFNGVIWPHVAYQWARRAKIPYHAEHRNILVDAFLGGFWVAAMQFN
PLPSAATLSMMAMHNVAIGGLRFLLAGAVAQILGIGLGLLVFMPAFVPQTSPFQLYACLP
LLSIYPMSLGWVCFRQAHTLGRHKRELLALSRTDSLTGLLNHGAWKDQLDIEFQRCRRQQ
KGGAIALIDIDHFKTINDTYGHVAGDIVLRQLSKILKQNLRAADVAGRYGGDEFCVLLPD
LPLERAAVAMDALRARFATLGYEQNPALKVSLSIGLAAFNPDHDDATLWLNDADQALYEA
KTTGRNRVICHGDGKPRKELLDSV
>A0A8F7LDS0|diguanylate cyclase|EC 2.7.7.65|Rhodococcus globerulus|TrEMBL
MGRVTRLLVVFVVVLLAALIGILTRPPGLLATFWCANALLLGMMVRWPILIEWPTWIAAG
VAYVSADLLTGNTLSMAIQLNGANLVGVTVGVLLLDYLKRTPFRLVDSTSLMWMVVVAGL
SACATAATAGLMDWVFRGESFADTLVHWGSTEFMAYLLVLPLILSMTIPSSIAEIRSKTT
VRAVLAITVPLLATAACMPIALSIEGPIALLLPIPALLWCATRISVPSTALVSAVWSVWS
LMMADAGRLALGEQSGANVNEAVITSIAVTLVALGPIAVACATQERRAAERELFRAVEYD
SLTGVLSRGPFLRQAEERLQQATQTALPIGLLMLDLDHFKAVNDTYGHMVGDSVLADFGA
RMAERVSDTDLVGRLGGEEFAVLLTGSSFARATEVAEEIRHAQVHDSARSGHDSTVSVGL
AWTNDSTPTLASLMVAADAALYEAKHAGRNVVKAENVSDIVSGVVPERITRTA
>A0A7T8AQB7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter variabilis|TrEMBL
MNNECMAMLAEQWKQICQNYSSDDLLHAFQFIQDHSLVLVEEFYKNMLLEEEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
MFELLSLNPQPNMLTTCSYIVQIMGFATEIMCHSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDTLNQAVLECTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDSDERRALNIAENIRTYVEHGLINTSQGQQFRLTVSIGCAL
FDGHPDYQRFLDAADAALYMAKNTGRNRVYLAQPSQIQGTQKASV
>A0A6M8MDJ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MSFPTTTNAIDFDSARLQRHGFAPQHSLVRPALDYEQLRRQLDLQLQTSLEADKILSMLF
QSIQQLIPLNALNFKHLPTDLRLELGERARHNATYSMTHEGKQLGELSFQRDHRFAEHEL
EQLESLLSSLLYPLRNALLYRHASLSALRDPLTGAGNRIAMEQSLIREFEIARRQQQPLS
VLMLDIDHFKGINDTHGHATGDEVLRAVTNAVKDRLRNIDQVFRFGGEEFLIVLTNTSRE
SAALVGERLRSAALQLSYPVTGRPLDLTVSLGCSTLLPGESSDSMLRRADTALYAAKRKG
RNRLEMAG
>I6CSW4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGEAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A085HEX9|diguanylate cyclase|EC 2.7.7.65|Leminorella grimontii ATCC 33999 = DSM 5078|TrEMBL
MKTYLSKMKQEWAELIESTSPEVLSLAAKIAREHAVPLSQTFYEIMLDDPEAEVFLTNEQ
VEKYLKPALAEWTENVLTCTQDNIDQMISVQQHVGEVHARIGIPVQLVEMGARTLKKLLF
PLIQTMEYDCTDRDRVALCRFAVVSIDLAMEIMSRVFSFSDNSASREDENYRIFSLLENA
EEEKERQSASLLSWENDLIYRIMVDTDMESVRPLSRADFGLWFNHKGRHYFSGLPETGYI
AKQLQELDELVIRTQNTPKALARREQRVSLLLQVKSALLQISIFLKALFDEVSRHEVGMD
VLTRLLNRRFLPTIFKREIAQANRNGTSLSVLIIDVDKFKQINDSYGHQIGDEILCKVSQ
VFYNNVRSSDYVFRYGGDEFLIVLTEASKHEVRQVAERIRAMVSKQTVMAPNGQRIVLSL
SIGGAMFSGHPDYERLIQAADEALYRAKTLGRNRVEM
>A0A0S4X378|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum|TrEMBL
MSEPAQRQETSPLRTDDVTGMDPCRAPSRMEPAPVVLIVDDEPSILSALTRLLRKPRYTV
LTAEGGEAGLNVLASTPVDLIISDMRMPYMSGADFLARVQARYPDTIRILLTGYSEVESV
VRAINEAGIYRYLNKPWDDHDLLTTVAQALEQKRLSREAVQLTALARKQNDELRAFNAGL
EAMVLARTEEVQRLARHDPLTGLYNRRVLAAELEAAIAESRVTGCPYLVLIIDLDRFKPV
NDLRGHRVGDIVLCEIAERLKDALRRSDIVSRLGGDEFAVIAKADRGSYAESAINLAGRL
LAEIRKPVMIDGNRIEIGASIGIASCPSDGSDAEGLLRSADIAMYRAKREARGSFRFFEQ
RMDEELREQRELEVDVRAAINNGLVLPHYQPLIDIRNNHLYGFEILARWQDPVRGAVPPD
IFIPVAEQLGLIPRLTSSLLRHACSDAVRWSNDKIRLSINISPSQLKDIRLPDQLLAILD
AESFPPPRLEIEITETALVGDIETAKAVLSALRAAGITVALDDFGTGYSSLYHLRELKFD
KVKIDKSFVQSMQSNNESDKIVEAMIGLAKCLGMPAVAEGIEDRASLDHLIFKGCDFGQG
FYFGKAMSAEKAKALLTAFEDTSAIVDSKR
>A0A5E1AW28|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAT
LGKQGQFAVAEVLNAHKKRFAYWSWNPEENNDTLGALVSRWLFPDPVAQPIMHNGNAIGE
IRLTARDNLISHFIWLSFAVLTGCILFATAVALTITQSLHHGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRSSIAALMHDASAKTNTALLFLDGDNFKFINDTWGHAAGDCVLIEVARRMVEFGDKRHQ
SYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDLHNGQTATMSLSIGFALAWESA
SVEALLEQADRNMYQDKNQRTKAIT
>A0A8F8GZE5|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A5P9HBT4|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MLLRSSFPNIPLLGGLRPGLAAMVLLFSLATGAMASSGPPNIESVAMLADPGGQWQAPAL
IGREDAFRPLETRAEQSIGYTGHPVWLRLRVSGGAHGASEAVLRFVYPLLEHVSLYRVEN
GAIAQAWQSGLALAPEHRVLAHRLPAFPLELEAGETVTLLARVESAGSMALGVELLSLEA
FRVANDREMFWLSAYVGLLVALGLYNLLLFVGLQERVFLLYALFVGSFCVAVVTANGLGP
LLLWGGLGEATARLLALCFTLSAALGILFARQFLRTRHFAPRWHRGLRWLLLACLAGLIG
VGVLPRHLALQLMDVVGLATCLSLLACAVTCAYRRVPGARLFMLAWAFLLVGASIFALRN
LGIIPSNAFTLYGIQAGSALEMLLLSFALAARFNTLKRQREKAQAQLVASLKTQEAILEK
RVAERTAELEEMARQDTLTGLLNRTGLADRAAAAWGRREKSGGPLAVLMLDLDDFKPIND
RFGHATGDSVIRVIAGRLRHQIRQHDHCARLGGDEFLVLCEDLSGLEEVEALKRRLEAAI
RQPIRLSDDTAIRVGVSIGIGFDDSRTLDLEALMQRADAAMYARKRHRQRRPTSP
>A0A484YXM5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MISVIVTMTFIWLLLSFASVVTLKEYAQKNLELTGATMSHNLEASLVFNDSLAANETLTT
LGKQGQFAAAEVLNVHGETLCLLVLEPAG
>A0A5E1AKU5|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A5Q2K1B6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MQRDTFVVRRSFLHGLRTRSNPGLIVNVCFLVVLIFSTLLTWREVVVLEEAYVSSQRNHL
EIVANALDRQLQFSVDKLLFFRKSMNEALSTPLAFGVLQDAVSRFNALRTKPFWQLAVDK
SRTLPVNGVSDVFVEKTTLLNRDNALLNHEISAALEVGYLLRLASSSSHRESRAMYISRA
GFWLATDAPAKTTDAISRYYAFVTQPWFTGQSERENRAGAVRWFYASTPSAVEPHSTITA
SVPVYHDRYWYGVIALEFTQATLRRLLMEAVDDRTEGEYQLYDTRLKLIASSELSSATVN
QFDAAELAQIAKAIEGDTEGGLRMGSRYVSWVRLGHFDGVMLRVHTLDEGVRGEFGSISI
VLALLWALFSAMLLISWLLIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERANRLA
RECQAQSRPFSVIQIDLDHFKNINDRFGHQAGDKVLSHAAGLIAGGLRPCDVAGRVGGEE
FCVVLPGLALPQAAAIAERIRSRIDSKEILLKKSTTLRISASFGVSCAHEKGNYNFDQLQ
SIADLRLYQAKQRGRNQVVWQDHDKK
>A0A1J1LK66|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MASFFKVLQCMFLSSNFEENERLETLYRYQILDTPSEAAFDRITLLASRLLKVPISLVSL
VDQNRIWFKSRLGLEYPQVDREGSFCGFAMYNPGVYCINDTLTDSRWCNHPLVTGEFNLR
FYAAAPLCTSDGQRLGTLCVMDHHPRQLSELEVQTLQSLGELVIEQLDLRLASQRLQQTE
IALLQSEDRFRSLVEQAADGFLLHDLNGQILDVNQFACQSLGYTRQELLKLSIQQIETEE
IPALFLQSLVPNEPITLRRIYRRKDQTTFPVEVRVGLIQVGEQQLIHALARDISDRLQIE
QQLKQQAERERFTSRLTQRIHESLELSEILNTTVTEIRQVLQTERVIIFRFDDHYGGEVL
TESQTKGCFSLLGNRYTDSCIQQTLGLENPQKIKSVADIDTSNLSCCHYELLHKLQVRAY
LVTPIWHGQKMWGLLLVHQCSSPRQWQTWEQELLVSLSAQLAIAIQQSELYHQLQLVNHE
LKDLATSDSLTGVANRRCFDDYLHHQWAQLSQDQLPLSVILCDLDFFKRYNDTYGHLAGD
LALREVAQGINRVMRYPGDLLARYGGEEFAVILPKTDVSEAILIAQNIQNQIEQLKIVHE
GSLVDTYMTCSLGISSVIPSEKIPPKQLVAMADQALYQAKAQGRNQYVVSSLSSSFSQKK
>A0A2X1AF47|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MSNPTPAVAASSRVPEPSLDPQSLERLRALLSANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRSWLIALFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDPAAFDLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRAGLMEWSQKTLFRILGSGGVDGAGALGASPFGLWIRHRADFLFDGSPHLSRLNAAMD
RIDRELLPRFTPDAAPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKAITTGGLTPFHITASIGVAAHQ
GHPDENYLVKAADDALYRAKQNGRNRVEQDRRGA
>A0A6I6H4J8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas alkylphenolica|TrEMBL
MQQKSPSASRSRLLLPMACAHPRRTVILCFLAAFAISLVLAGRQYYQLLQRELQEREHNL
HLQALAIEAVVSNGKSQLQFMRNIAERLLIEAHIQPAMRRNEAIAAAMRNSQQPLWELPV
PKSDAPVRAIGDARLANIPGLSREPQQLIEDLHLAHAMSQVLPAQFQGESNLSRILFLTT
SGIVIAYPAVRDEQLEPILRKFTRSPLMHLNRANAEDLDIAFYPPPGSNLGSMPHVLLST
PVYLNAVMRGALIYDVPQTKLQNYLYQTTASDEQHALIDDEGSLVASSEQTFKPLPGDWL
GSLPASSMRLSIPMLFQRDHGTLKLDQGYLQFRELQGIDLMLTNYISAADLRAAVNAQID
ILFLGVWAVLGMLMALTLYIVDRLFKGQLRLNRQLREMGLVDGLTQLANRRRLQSDFGGL
LQRLREDQPLALWMLDIDRFKHINDNWGHSAGDEVIKHLATLCRALVRPQDLVVRYGGEE
FCVLLPDTSLAQATQMAEQLRAATAQSVCVPEAGTLLAGAPSLEIRLTVSIGVAELRVDG
CLGLEDLVATADRRLYAAKKAGRNRVVSSD
>A0A379ZGS3|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MPSIAASTNYDETLTKIEKLQHSDLPAAINLLKTIESEFDTMSRSQQGQFLVFKGAASIY
AGQYQAAIDMLSRSETLLKDSDMLFSAYSYEATAHIALRDFNDAFNAMGKSLGLIERIDD
INLKRASYLRLASLYSAMGIIEEVPTYAAKAYALASPNDVKDICVSKLYLSVHQLEIKSY
FQAFEEFKSTRSYCESNGYPLIAYIALKGMGESKLRLNEPHSAVSYLLDSLKGYESFNFQ
LEINSAHELLSETYLMLQDFAKAELHAQYIMKLSDDSSNTMLKHGASRMLAKLNAQNKQF
EQAYEYSRKEQQYNQLIFDESKMKTLAYQAAQFNANEQSREIYLLNKERELYVSQQTVKE
REYTNMLMFITILLGGLFFLGILLAVGHAQKRKFMRMARMDALTGILNRGAGQELGENLF
VQATARGGDFCVILFDLDLFKHINDSYGHGTGDWVLKKVADSLKSYIRNGDVFARIGGEE
FAILLPYANEEKGMEVAELCRARIEAIETQHSGHKFVITASFGVSGLMADDLSLDPLFHR
ADMALYAAKSLGRNTVVRYSEALKCDQQATDLRRYIASTSIS
>A0A829FV36|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE36|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGTPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5B0KDL2|diguanylate cyclase|EC 2.7.7.65|Pseudocitrobacter sp. 73|TrEMBL
METYLQKMKDEWAQLIGDTDPQVRLLAAEIAGEHAKVLSQEFYSVVLSDSQAADFLTNDQ
VERQLKTALQQWIIDVLSCQVEGVEQQIQVQQRVADVHARIGIPVDLVEMGFRVLKKLLF
PVISASQQSSDIKLNVFHFAINSIDLAMEVMSRAFIFSENSAAKEDENYRIFSLMENAEE
EKERQIASLLSWEMDLIYKIMLDTDPGNNVPLGQSDFGLWFNHKGRHYFSGIAEAGHISR
LILEFDDTFRAVRGSAQAMNNRTRRVNFILQTRNTLSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHAGRAGTPMSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YEHVRTSDFVFRYGGDEFLIILTEANEADTLRIAERVRSRVEKINVTAPNGESISLSLSI
GAAMFNGHPDYERLIQLADEALYGAKRRGRNCVELWKAS
>K9NM94|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MSQSDTRATVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGQEPELNR
HLDRVVNDFDSFPPESAAKLFREYIIRDELADARSGQQEAINLVDDMERDVSRSVKGNQN
FQASLGQYLQMLEEPATERLPSILIQLQQSTQLMQSQQEHFLSQLQSAQHEIKSLRDKLE
RAQLAATLDGLTELLNRSTFNRKFEQAMNDAASGLALVMLDIDHFKQFNDQYGHPLGDRV
LQHVARVLRESLSGEAFAARYGGEEFCVVLKDCPDLAAAGAFAERLRLKIQSLRVKARGT
DTVLDTITASFGVAHAQPGDTPESLLTRADDALYQAKRNGRNQVRQQPDVPVAAG
>K9NLW3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MILLWTSVILGSMTLTLIVALIWREHSLHKQLAQYRAIINSLSEGRNIHQAGDAERFKRS
QYFARIGTWDWDVDTDRLYWSDAIFGMFGFKIGEVTPSYALFCSCVHPDDRLRVRAGELR
CLETGENHDEEYRVVWPDGTIRWLRETGNVVKNDHDETIKMMGVVRDITEEKASANYLKH
LAHYDPLTGLANRLVLEERLSEALEQARASATRVALVFVDLNGFKAINDRYGHAAGDRVL
VTTATRLKRILRGTDTVARIGGDEFVVILQGLPQGESLQDEARSICQKIFVELSPPVTIG
NDQRHIGTSLGVAVFPDHAPSIDRLLHIADLAMYEAKRSGNNQYRLGTESVVRAHSE
>A0A399F174|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MTGATTLDRERFYQSLANWKDDGPISVAVADIDEFLAVNQNYGREVGNAVIALVMKALAG
SLPPGSLLTRLGGDEFACALPGASPEEALIQLEEIRQYLAGRKHNVGEVSLAVRLSIGIA
SFPRHVSDPQQLLQAADEALLRAKREGRSRVAIYVEDRMVLKSNYYPKNQLARLATLSER
LGRTEAALLREALADLLDKYREFL
>A0A8K1IUB5|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MLPPTCTQLESEWQTSDPVKQLLDALPICLSYLDRHRRYRYVNHNYETWFNIEPERIYGQ
RLVNVIGKQAYRAVRAYVNRALTGETVTYETSVPYSRGGTRYIHATLVPDIDELNRVQGY
YALIADISDRHRLEESLRASEQKYQTLFQTLPVGLSITDADGKVIEANPASEGILGIASR
EQTQRTYDESSWQIIRPDGTPMPACEYASVRALEENRPVLGVEMGVVRPDNRVRWIRVSA
APIPLDRYGAAIAYIDVTEQKQLELALRESEIFCRTITDIAPVGIFVYDLNRQTVIFANA
AYESQLGYCLAEIQALGRDWLPTLYHPDERDAVLAHKKRIKGDRKDCVYHKEDKCRCKDG
NMVIVDTREVVLNRHPDGTPAQILGVGIDISDRKATEEALNRKVQQERALNRVIEAIRRS
LTLDEIFTTAVLEIGQFLQGRVAIVQYLPDEGCWRHRALSDWESSQAEALQADVPDEDNP
FAARLKQLQVVQINDPASIREPVGQKLLKRFLGIWLLTPISLHGRIWGSLSLNRPNDNSP
WQTDDIDLAGHVADQLAIAIEQSSLLQQLNRQSQELKQTNQDLARINARLNKLSCTDGLT
QISNRRHFDEEVRKEWLRLQRSQDPLSLIMLDVDLFKRYNDLHGHPAGDRCLVEIASTVK
QLLKRPSDLVARYGGEEFVVLLPHTDLNSAVQVAESICIAVRNLKIFHSEHDGKPAYVTV
SLGIASQIPNLFGSVEDLIDRTDLELYRAKTRGRNTWSYRG
>A0A2X4U9F9|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MNARSYQELLTSKHRLSLFLFLLMNAASSIFTILVPFQGKPAFTLPLLAIPLFCLVALLF
TLQSMRQFVKKLNLFSCVIGLLWAAHIYIKSQYYAPNNQGFLLLSLFSMFFISAIALTDN
FIAFCLHAVPSALVILFLDGMHNTVRIVFTTVLPIIAFSIHHLMLKRSEAFTKTLVANLY
NERDRFSNLSMIDPLTGLYNRRGLENKINMLPESQSGRHFVLLLDIDHFKAYNDNYGHTM
GDQALVQVAIAIRDSVRSRDIVVRYGGEEFLVLLTNVREDYAAQLAERVRQRVQELKIPH
RFNQLEITNVTLSAGIAMLDKLDVASAIRAADAALYLAKNNGRNNIQLAENVQAAVTP
>A0A3A3Z9K2|diguanylate cyclase|EC 2.7.7.65|Enterobacter chuandaensis|TrEMBL
MDKDFTTTPRPTFKRTLRRINMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINVHNKRFAYWSWNPKDNNDTLGALVS
RWLFPVPVSQPILHNGAKIGEIRLTARDSLISHFIWMSFAVLTGCILFATVVALTITQSL
HRGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSEPEVQHICAALAQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLEKADRNMYQVKNQRTKTIS
>A0A0F6B2X1|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain 14028s / SGSC 2262)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A509CHL7|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 6947|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A509CNU5|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 6947|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCMPMIGIVVLSVLLLIW
HGKYGQKSINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A7T8RCB1|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MFPKIMNDENFYRKAVERAVAPPASQNEQQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPLGGGWWLLLVGWTFVWPHLAWQLAAKARDPLSREIYNLKADAILAGMWIALMGVNLL
PAAALLMMMCMNLMGAGGPRLFFAGMALLWASCLVTLQLTGLPVATRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRQHWEILLRDEFDHCRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVVLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A837FCS4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. xiangfangensis|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPSLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMHDALETPLAFGALHDAVKRFAQLRTSPTWQIAVDK
RRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYHHVWYGVVAMDFTFATLRHLLVEAVGDNPEGEYQLYDSRLTLLATSESPAVDVN
HFDARELAQLAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFDQAKILA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHLKK
>A0A173SHK7|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKVKTILSRIYYIIVAVCVFLHVVILSLSFFDNKHQEKYCRSIIPDREYQTDEDNRRFVF
SAQKIKDGGDCLRFYTAHMEVSVYADDTLIYHVGQQQAMPKVSPGVMWNYVGIPSGAEQI
QVMIRAVYPEVRQKQIDFSIGGYTQMYSGMLYRSMPVTFICLLEILLGFFMVLWWLIART
RMKMKQTLLHFGTFSFLTGTWALNETDAALLILFPVRVEIVFVSAVVLILMVPSFVWFTK
GFFDIEDKWGSDIICTLAYLNLAVQLILQLAGIRGFRQMYTVTHVLLGITLLYTIVMLIS
EYRKTKVHRHLWVVVVGGFILLGTLAADLLHFYYGSFQTSIYDIYGVFIYIIIFAAEVCR
QVAEQVDAGQKLQIYEELATKDMLTKLYNRNAYDEWIKVNRWPKKAKIVVFDLNNLKQCN
DTMGHAAGDAYIQNAAGIILHVFGNCGNCYRIGGDEFCVVIYGNDPSDMEELFRQMKQEQ
DEFNSKNAIPQIQIAYGYAEFDPETDRDIEDTRSRADDKMYQKKREIKAGYQ
>A0A846V1J3|diguanylate cyclase|EC 2.7.7.65|Dyella sp. SG609|TrEMBL
MSKAAVEGHLRFVTRVYRLRLLGLALGALPVASVLYQLHAAWWLWGLLGVNALVWPHLAH
LRASRSARPIETEHGNLVIDAAMGGAWVALMQFNLLPSALLVAMMAMDRISAGGLRLVLK
SLALQAAVCLAVWWLNGFRLQPASTMLNVAASIPMLMIYPVWMSMVNFTLAQRVRQQNRQ
LDQLSRTDALTGLNNRNHWLEAAGVEWLRYQRNQRPAALILLDVDGFKQINDRYGHAAGD
QLLGDLARLLQRGLRDVDTPGRLGGDEFGIVLPETDLERASAVAERIRLLAENSRPERGD
QHIPWTISLGVASVGEDARDVGAWMRQADLALYRAKAQGRNRVCVAPARGSGGHVAHATV
>A0A840UFP5|diguanylate cyclase|EC 2.7.7.65|Marinobacter oulmenensis|TrEMBL
MPRFSPEQLSAEWQAVNQRFSNETRQFVLAFVRDNSASLSAHFYREMLADPAASQFLSHE
EVHARLGRSMERWLSVLFATATKDDLLSLIAEQRKVGEVHARIDIPVHLVLRGTRCLKDR
FHVLLDDHPGLSESQRISAARMVCDTMDLAMEIMSHAYAISHDRNSRAEEAYRLFAITQN
IANEKEQQRAALLDWENQFMFNHAVGTDGTRMPRIQASDFGLWFRHKGVHAFEGSPEAEA
ILDAMEHIDDVLLPLFNTSVQAAPGAGDKVQMLREFRDRVKGIQFHLDHLFEQNNELESG
RDVLTRLLNRKFLPVVLGKQISQARNRDNVFALLAIDIDHFKQVNDQYGHQSGDAVLQQL
ALILVNNTRSGDYLFRLGGEEFMLVIMDTDPTRVRSIAEKLRRSVEQEAFRLPEGETLNV
TVSIGVACFDGHPDYQKLMHRADAALYRAKHGGRNRVELAEHLELRE
>A0A1V5UGT2|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin239|TrEMBL
MILAMNIQYINASTDFLTGLANRRSLSNHLHNRMTGSDKQSSFSIIMFDLDNFKMINDTM
GHNVGDDALRQFGRFLRNNCKDVDFVARFGGDEFILVLDSMSPEQLTQKVAIIRESFKLY
EGNKVGDFQIGFSAGYFIHTKDLNLSVSELISIIDERMFKDKRKRGNGLI
>A0A060DNP6|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALAEAEAISKVFYAILLDRPDSNTFL
SHTLVQERLRPSLARWIKALFTASTDTAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISAKVSAAVEGGWVTPAFVKELNNDVTEIAYILGTIIEKAMEIENGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKAINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRMVEEHRFPGAGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A174BTT1|diguanylate cyclase|EC 2.7.7.65|Mitsuokella jalaludinii|TrEMBL
MKLFYSLKRKVLAVCLAGMILMALCVGGISLWTISHLTYDYEIQNMNHLVDTTATIIDDE
LLRSENIVNYTANAISRKVDDPAQLRDLTFRQHLARSVDHDFQDASTNLHIICSYYLYYP
SENISALWKASNGRDSVFDDVLAKQQEDFGHTAPRHVLAFAYLMDQGEAAWTQPYYSSYL
NRYIISYLRPIYKDGVMVAIVGIDIDFQAFIDRLYANPPKGEHGMIMLCDATGSMEYSPE
APLGTPVAEKGIRLVDPPETVAEAGRTDDEMLRYSWDGQESIAGIRALRNRMNIIDLRQK
PQIYSRTHRAMMQMGMGLIAVCIMASLLPIYMINRLSERLQRVIEAAKEVGEGNYDIKLY
DTQLDDIGELSRNFQAMVGKVAASQGNLTYMSQHDVLTGLFNRMGLDKEIADWLREHPAS
HGALVSLDLDGFKFINDLHGHMAGDEALRTLARDLVENFGHEQIIGRNGGDEFVVFMKDA
EPEAAQAAVKAFSNKKKSFTYDGETHSFSVSIGYTFYRGDGMRLFHESDTALYAVKLRGR
NHYRAYEPSMESLNRTSLGFNLETITKNLPTALLVSEAKPDGKILFVNKTMVEMLECRNI
REFMEFTQEYAPNVVCPCDRERMTKMVWEQTVREPDRPHCMTYCVHTVKGRDKQVFAIWR
QADNVNYGKVFYATLIDGHFMYEELASSDGSAEGGTPNRDS
>A0A498D0F7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter cumulans|TrEMBL
MPQNVSIQLSETWKSICYQYSALDHHLTVELITKNLDAFVAAFYKQMLLEPESAEYFSDN
IIQKRLIDTLKAWLLETFNVALNGQYESAVLRQQKVGNVHARVGIPSWLIMRGVREIERT
MFEYIASDNSTNYMNVVSYVVQLLGFSTEIMCRTYEDKTAKNHEVKHSYRLFSAMQDVAV
HKDRQRGSLLDWENDLMFKIFSGQGKFYQQLFSKSEFGLWFIHKASYAFTGSEQVGLITK
RIYEIDALTEECMLLEGREQLMLMVQKIRSINREIQHLVDQLFQVTEYIESGNDALTQLL
NRRYLNTIVGREISYARKHRSALSLLALDADYFKTVNDRYGHAAGDMALKFIAETLQKFS
KGSDYAFRIGGEEFLLLLVDSDLSHAKMVAENIRMCIEDTTLQTSVGEDFNFTVSIGCTQ
YDGHPDYQRFLDATDLALYSAKNRGRNCVYVTEVQKMA
>A0A8F7QFJ5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MTKQGKAFAIIAITVFLCCLLGILTRPLSFLAFFWPANAALLAIFLRFPQLNNAGGWIGA
FTAYMTADLLTGNYFDLTFFLSLSNLLNVSVSLFFINYFQINYRNYSKGFTFLYLFAICA
FAGCLAGAAFAVFTIPHVPNTFMSADRFWIDFGMWWTGELVNAILIIPLILSMPTLGELK
LAFRKRRHKQYPLSHIFPLIAIFICVLMTYFLAGPGALLYPLAALIWAALTYRLFSVAVI
NFAVLLATYHSLNQFYLSESSSAYLSTSISVRIGLFMLSLAPLILCIISQNRHELFKQVL
YLANHDSLTLAMTRRYFFQQSELLMQNAKRHPFSIIMLDIDHFKNLNDQHGHYAGDLVLQ
DFARTVQDNLRNNDLFARIGGEEFVIFLQNVQLQEAHAIAERIRAITENSPINIHTKAPL
HITVSIGIMHHNFTEQKTLQNLINNADNALYQAKKQGRNQVASFNSSEFSSAIQL
>A0A8F7QI46|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MQSVNLPDTQYFLLVVPVCLILIGGVFIAAHLVFKAPKYLLWMGIGCILPYLALGLQSLM
TNEQLTATAPWIGILYLGGAWSVAHGMTVKANSQPKPILSAAVVALGLMFLFYFAYVDEQ
LWFRMITINLIILCLEALALPAVYALYKKSSGLLKLLSFSYFLLFSYALLRTLAVVFFLQ
NVDRIMLSASSWWMLMLAINIVLSLWFTIIVSASTIKEFFTVLNEERIRDPLTGLYNRIG
FFEKSKALFIDPCAGHIYVVMCDIDFFKSINDTWGHTAGDQILCRVAALLRESIRQKDIV
ARFGGEEFIILFQSTDEASSYYLVERLRSKIEKQLFMNNIKVTASFGVACMANEEDLMNA
LEMADKRLYSAKNNGRNQICFEL
>A0A447IGA0|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MPTMPAAPVSGPGRDYATAASRLLLVLATTIFFASLAGILSRPNGFLAAFWPANAILAVI
LLRVAAPMRFPALIGGLLGYQAAGYATGDVSWGAIQLTAANMVSAVTFTFAYLSFCEEQM
SIGRPRAILALVGASVLAAAAAGVAGAPILAEISHASYFDAWRTWFGSEIMSYLVLVPGL
LALGWPLRRPRLADIRRLTASATLLPALAVVATLAVSVVAVEPIAIVFPVPALIWAALVL
PLPATCLLVMLFSSVTMFAVKLGLYDFGTGGLSDPLISSVHLGVAMIALAPVLVAAVTAD
RRRQFSELEKAARFDALTGALNRGAFMAEGEAMVTAQRRAHAPMAGLLLDVDHFKRINDL
HGHAAGDLALTAMAAVIRKTIRGGDLFGRLGGEEFALLLPDADLDAAALVANRICRQIER
LQTPIADGTILTMTVSIGVVASVETTVELSEVLSLADRAMYEAKRAGRNQVQRCDLDAMH
YDEDSDHGGNRPVSGSQLQADSGHHSV
>A0A0T9NWC1|diguanylate cyclase|EC 2.7.7.65|Yersinia similis|TrEMBL
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELF
YTPEDLVNGLSVKGLQHANQFGHYESQGWRVRKNGKRFWGNVTLSALHNSENILQGFVHV
TRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGRILTWNKGGERHEGYTREEI
IGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAINPIHDDRG
NLLGFTKIVRDLTERRQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNLGAQRN
IGYASNEIIGQHFCCFFLPEDIVAGLPGKLLKTAASTSRIEHEGWLVRKDITRYWALTVI
TAIHDHNGKLLGYTKLIRDMSERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNS
EGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQNKNQLEAFNQCLAEGRHTLLPE
GHHLVSRRGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRELQYQASHDMLTGL
INRRRLEERLTQAINQLAHDGQHMLCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCPSQSAAEILEQVVADIASIQFHWHGQSYVLTASLGAIPL
TQQTESASQAMRLADIACYKAKHAGRNQLSLTS
>A0A1R7QAT2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MINKNQLTERSFTPSQLSSFDGAHSIQLPVDFIHDLSKADSLQAVLDTIAYWISHVFDAD
RASITLQDTEEYLKLYSISGNHAIPMDFKIPIGQTFVGRVFAQSQLIICDDLAQSDELDC
KMLSEHGMGTCMDAPMIHNGVCIGTLNVADQRKHHYTLQQAILLQSLATWLALNIKLHLQ
VQEMAVLASTDELTGTFNRRVFVQESNQTMQHFSHTRVPFTIGILDIDHFKQLNDCYGHT
AGDHVLKKMTKKIRSVLRDEDFLARIGGEEFAIILPACLGDEAMRVFKRICSTIEAMEMH
YEQEVLCFTVSIGVAEVGKHDADAEDVFKRADKALYCAKQAGRNRIHFAN
>A0A1R7QCP2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MGSLLLICHFAFRAPSYLLWLGLGYIVPSFSVAAQSFMSNKQLALSAPILGSMYLFGAWA
SAYAMGLRKNANAHSYWCLALVVMALLSLSYYSYVDDQLWIRMLILNISIALVESLVLFS
IFKHYQGIDLLNKIVDFSYLFIVLYTFVRGIIIFLFLRNIEADMLANSVWWLMMLAASII
LSMWFAIVLLGTLVRDIIHQLNDERLRDPLTHLFNRRGFNEAAKRKLHQLSKQSYFLLMC
DIDHFKKINDTYGHLVGDQILQQVGQIIGQNVRDHDLVGRFGGEEFIVLLQIDDPTLAYN
IANRIRLGIADARLSSKSLAVTASFGLAAVHQPNLKYAIHTADQLLYQAKHSGRNQIGFE
PAQSILDVSH
>A0A239RU19|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MREIRSEYLSQKLYIAMSIIILSLCSLSIPLIVKSYRDYNKTNQALTEIQALQAVADLAN
KISRERAPANKLMSSNQQDFAKHVLELKLYRLTVDEQMKKTLEVLKHSNLPNLDLSLVDR
LDEALTQGRQQVDAYAALPREQRNAETMDQAILKMFNAWDRSHDVLKDVIAVSEGKDTAI
SNFYTQILLLADLRDQAGRAASNVMAHVTFEQPIPETNLARSLQTRKQVMYLWELIDTLQ
PERDKTEEFKVLHQAVYNEFLAKGLLIVERLMNESIYHRPYYLTGTQLTEAIVDKFSTVV
ELQKYLLKYSVEKAIIEKHKAQNILLTTVGISLISIFAALFTMIYARKRVFSPLIQAREI
LFDLSHSSIRPNPMDTKDQPANMYSLFTAIQQLKQTLQQRDALEFRLKNIAHLDSLTGVA
NRYALNEYIKLLENQPTQFSETCLMVIDIDHFKQVNDVYGHLMGDQVIQFVAEKLKENIR
TSDLLVRYGGDEFIVLIENVGMERALKIAEKIRSEIYEAKSVDNVRCPDLKVSISIGVAI
GATSWMALLEKADRALFQAKEQGKNKVVAYSVDEVNESYYI
>A0A7W5TLX0|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK650|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAADGHEALAICDRNQVDLILLDIMMPGID
GFEVCERLKANPKTSHIPVVMVTALDQASDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRVRAETAQTIGIDELIRAGDGRLDEAGQILLVDSRANSQERIIKTLKPVAD
VIAISDPQAALFEAAESAFELVIVNTNFDDYDPLRLCSQFRSLERTRFLPILIITEQGAD
DMVIRALDLGVNDYIVRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
SNRRYLDNHLNVLFSRSMARGRPLSVLIADIDRFKQVNDTYGHDGGDQVLKEFANRIRST
VRGADLACRYGGEEFVVVMPDTSPEVAAAVAERLRAAIENTPFLLKLSGETLNITASFGI
SSRIASVITPDQLMRQADLALYEAKNTGRNRVVASAA
>A0A0Q0NYX4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MLCSTSAFASITDYVVKQWNIQNGLPSQSLKSIAQDEQGYMWLGTQFGLSRFDGNTFTNF
NTQNSDFLPSNGINKLLVDSTGLLWVGTKNGLVTLDPKTMMSQTFNVKGPVRDILEDSKG
SIWIAANGLYYVARNQVTLNQNSALIVPVSNATAITQIVGSVSQMALSPEGIWLVNERHL
LRLTNTSSDFAKLRLELTAKVSLPERLAQTIIHDMAWLEGNLYLASELGAYFLDLDDELR
PFPLPNASNSAVYKFMSDSDGALWISTYGRLLFRDNSGDWQWVEPSQLDQSIWFADIFRD
NQNNIWLASFSEGLWLAHEGRIERHSAISNMTEAVMAISQAPDGKLWVANRSGVGYFDYN
KNFVNQIPSNQFGRAAVHDLQFDGDRLYIATGRGVFYYENQNLYTVPGRALRDNPVFAIS
RSSKGGFWLGTGRGMYRLSYGGLTPFAYNAFLSSKFITYVLDEQNFGLIGTSKGAYYFTD
RGIEKIGDQTSLESAYVTSILNIEGVGILIGSLNDGLFYRSTKGQWRQLDATDGLPYGSI
FSLVYDKQLKRIWVSTMKGVYRMPVEQFGTDIESLKVEQVISSFDRQLDGKASQCCAGLG
HDAVADTGNSIWYPSLQGVVEIPKSVELFGVQALKPRIESLITPLRHLSTATLGSKPELQ
IDERDVTLKYTAIDYYAPSSIEFRYRLSGLDSDWRYANTRREAIYTNLPPGSFLFQLEAK
RRGEDWQKARRTEYSFVVPRRFDETIYFRLLITSSFILLFYLVFWVFRAQEKRKQLALES
LVTERTVELREANDKLNQVNSQLKLVSHSDELTGLRSRRFLFDQLPKDIEHFQRNSQSLQ
AQGKSLVLLIINFDNFSRINDAYGPLAGDSCLQQMATLLNSRTQGSDYVARWSGDEFLLL
LRDFKRTAIDNYVADLCEAIAANPFRLPNGESTTITASVGWSFYPLPLLGGQVIGWETSV
NLADIALHQVKKRGGDGVANITFDEQLDAFEFEQSHNVDQQLSALQANGLADIKIWMR
>A0A0Q0G2Y6|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MKLNDVQMFVNPIYRLIEITPIPVIVSSPSGKLEYANPALKQLLGYEGDEVYADDVVITH
ADDRELNKTIRAKLNQFPEQPLQIEKRYMHKLGHAIYCQLNIVAEMDNDGNVVRYISQII
DLTTVNKEAAADILLTHLVDKSNDAIFVANPQFGQILNCNQFAYKCLGYEKEELLKLTIP
DINPDYDTKAKWQERVARVKAQETTIFESSLKQKDGQVFPTEVSVCHIDHQGKSYLLAIV
RDISARKNKEQALIELANLDPLTQLPNRRYLEQLLNDVFSENGDVAEGMGFIYIDLDDFK
QINDQNGHALGDEVLVWVAKQLKAAVRSTDYVIRMGGDEFLVTISGVTNTTILNRLAHKI
AEQFSAPFSCKGKSIEVTASIGVTAHFLGDGVYAANQLIEEADAAMYQAKKQPGTTIIHF
S
>A0A0Q0KKP9|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MDIGALRGTQALRNNVLKWMGFCLGALAGIFAGFNLFINDFFVLGALEVVFASFCFYIFF
YTRKRNGHLWQSLTLCVFLTLLITLGTYLSNVKSLLFIWTCSLPVLFYLLLGKQYGKVLS
LLVAVLQGVILLTKSSLEPLNSVNFLLNFSFTYISIWAVSHTFENSRAEYGKRLENLALL
DPLTGAGNRLAMTHYFEVELKNKNGLFILMLDLDYFKNINDQYGHDVGDRILIEVTSFFR
QRISKGYVFRIGGEEFAIFLPDSDPQSAYEFADMLREHLATTIHNIDEQAINLTISIGVA
CYMPNQTLKNFIKRADDALYQAKQQGRNRVVTAYELSQQNKAS
>A0A0Q0HKC5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MILSAQAEHSLSYSSHCLKLAIPLMVKYKMPITPLNYALWYCYVSEKNQDLNKELDSIIK
KHNTCSHEQAKHLFNKYLSRDDLALFYQLSGGFNDVVGKVHQDINEALSYSAEFNQALQE
CRDTLTSADISQERGFDDVLDCVERLSDESAALQSRAQDFQNQLALAYSEITELKQELVR
SRSKAEKDPLTGLYNRGKFDEDITRFCQTNDLAEVTVLTMVDIDHFKQFNDTFGHQKGDQ
VLRAVSAKLLKHVSSVGQAYRYGGEEFCFTAQFASISDMTNFTQQLRHAVAKLQIKEPKS
NKVLSQVTASFGIAIKAKNSNPEQLIAKADKALYLAKEHGRNRIEIVEE
>A0A8B3JXV8|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MNKDFASTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGSTMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVLNAHQKRFAYWSWDPEDNTDTLGALVS
RWLFPVPVAQPIVHNGTAIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVTEMQNITDVVHDVRANRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDSSAKANSALLFLDGDNFKFINDTWGHAA
GDGVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSEREVQYICAALSQQFIRPFDL
HNGQTASLSLSIGFALAWENASVEALLEQADRNMYLVKNQRTKTIT
>A0A6H2GEW6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAITQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A6L5E821|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MPHETTMENWGWLKTLARRLGPGHVVNLCFLIVMLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQFNVDKLLFLRDGMHEALITPLGFSVLKDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDSFVNQTQLLSRDNESLDNELTAALEVGYLLRLAITRASLSLQAMYVSRA
GFYVSTLPTSLSSEITTRYYDYVIQPWFTEQSQRKNRTRGVRWFTSPSPELSYEQQRVTV
SVPLDNNYYWLGVLAMTIPVSAVERFMDEAIDKDVEGEYQLYDSKLKLLAASTPELRNAK
TFDERELAMLAHDIEQDTVGGLRMGSRYISWERLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKQLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRQRLNEKEILVAKSATLRISASLGVSSTQETGDYDFEQLQ
SLADRRLYQAKQAGRNRVCAADRG
>A0A447NRH3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sanjuan|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVVNALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARLSAMLTLETMYVSRS
GFYLSTLPTTYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7X8S3V5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDNMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADHSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A336QLP4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MQLHHKALRLFISVSVVVLTSSFLVYELIASDKAMNAYMRYINEKADSSFLYDKYTNQSI
AAHLMRTFSSPQAPASIEQQKALCNAFDSVNGTHGLNLTQHNYLPLHGTLQTTATKCNEK
LADVFLLPSFDQAVNVNREQKNYVHGLGTLEYKIRYYVDLKNNYVYFYDLVDSRKFAIHN
WSFLQKGSLGIDQNDIDGLFTGRTVISSIYEDNLTEKKVMSFLTPVYYAGKLKGVVMVDI
NKENLKNIFYTSDRPLVWRYLNVTLSDINSGKEIRVHQSENNLFSYVHYQKDIPGGIRIT
LSLDFMYFIVSSWKIFAFYLLATILLLNMVRTHFRLYHNVTRENISDAMTGLYNRKILTP
TLEQRLQQLVNAGTPVTFITIDCDKLKVINDTLGHKEGDRIITLLAKAIQTSIRKNDYAI
RLGGDEFCIILIDHPGELTPRLLERIRYNLQIIAQDIAISFSAGIYTMQPNDTIDDAYKA
SDAQLYLNKQKKRTGA
>A0A7W3FA00|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVIFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITSLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQGHDACSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEAIEEQAFRAGLVDPALSKALDRRVFSEFFQNAAPAVANKGLSIALPLSAAGLLNTELI
DELLEHLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A844CG30|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT693|TrEMBL
MIGNAFERFLSRYKRPQWVVNLCFIVVFIFSTLLTWREVAVLESAYISNQRNSLDNVATA
LDRQLQHSIDNLLFYRNTMHYALQSPISTDVSRKALADFAIQRTQPYWQLRLDLNRGMPI
NGVSDEFVTHNSLLDRDKSLLYPELGAALEFSYIMQLADGKRDLQRRMFYASRAGFFLSS
TPPENDPGIVSLYYRLIDQPYFVAQSPENNPDRGVQWTHTYNPGSRSGQIITAAVPLDLN
DRWYGVLAMDFPVNAMHQFLQSQSHDRYEGTVMLFDKTFTLIASAAEHVSRAPVFDVKQQ
AEIARSMESGEAGELRMDSRFVTWAKLMNFDGVLIKVHTLSEGVQGEFGRISIVLTILWL
LFTLMLGISWRVIRRLVSNMLTLQQTLSWRANYDTLTRLYNRGAFFDIARNLAQDCQRKE
QPFSVIQMDLDFFKGINDRYGHHAGDKVLSHAAALLGSVIREEDVAGRVGGEEFCVVLPG
ANLAEAASIAERIRVRINTKELLLVAGQTIKISASFGVSCAHERHDYDFEHLQSIADGRL
YKAKENGRNQVYTRDRSVHQGNSAISYKHC
>A0A6N2SNT5|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MSAKRNQRVQREDVLTYSPVLKYMVIFFTAAMFIVLVGGIFISAQRMKKDARAAHKSVET
QVTNRVNESLKLLESLAVQPEYYDPSLPPLKKVEKLDRITEKYGYMMICYVDADMNVYTI
GEEPASLASRDYMQQLFSTGKPQVTDSFLAGADGVTLNYTVAYPLKKGNKITGCLFCAIY
FDDVVDILKKAVETSDAQAVLIGSKGQIMSSTSNLQYGEPYMDYVREAHNIGVTADQLET
ELLAKTPGTYWSYRDGNLYYTMYNNIENTDWDILTTIDFWSIYRTIISGFLVIVALMAVL
CSVIFFLVKRFISKQKEVVDMLVQSIQELEEKIYQDERPDNMDFREIIRLTSNGLSDGLT
GVVTRSVFLKQAQAQLDKIPGDKITVLCFVDLDNLKKLNDTYGHKTGDTALKSIGYILRE
YEKKYDGVVGRYGGDEFVMLLTDIDDEDELRSVLESLVLRLHSDIGTKGESLPIQCSVGV
AVRQQGSSLEQMIANADEALYFVKQNGKGYYKIYQD
>A0A1X6Y419|diguanylate cyclase|EC 2.7.7.65|Pseudooceanicola marinus|TrEMBL
MSLSRPDRDAALSPGLCQSAEGAAGAVRGRADAEAADLPRDAPSAGIADGTGPVLIGQAA
HPLPPMPQGALDILAPMHLVLDATGHVSHAGPTMQKLRPDVPMAGQRFLELFELSRPRAV
DSMAALLASAGIKLHLRLRDAPRTALKAVLAPLLPDEAGRAGAVVTFSFGISILDGIQTY
TLHSGDFAPTDLTIEMLYLIEAKTLAMEASRTLNLRLQGAKIAAEEQAFTDTLTGLKNRR
ALDHVLARLIRTGQDFSLMHLDLDWFKQVNDGHGHAAGDYVLQHVARLMLDETRAGDTVA
RIGGDEFVLLFHNLTKRSRIEEIAARLLARLEQPVTFEGAVCRISCSMGTTLSSAYDAPR
ADQMLADADAALYASKHSGRGRHSFHVPPPG
>A0A6I6ER28|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J780|TrEMBL
MTIKTLTRVAPFNPTWVDGLLLGLLSFVVTVYCLELIKTTGQISPLWCSTALMTIVIFRN
PRHQLPLLLLGTLLGIICANTLVLGTSPYNLKFPLVNLVQAMAGGMLLRRLLDRDAPLNS
LFSWCKMMLTVGLFTPLLGGLLASWLSNVEGNFSLHFFTTWTLSEAIGMLAFGPVCMLWQ
RDYVRRHLRQNVLFETLLTLMVTLILCWFSLRYIPWPFTAVVLILFYSAVRLPRFEAFVI
YMATISMMSLMLALKLIPGDTSHFQALESMPWIPFLLALIPSHMMTLVMHSFREERKNIS
ESETRFRHAMEYSAIGMALVSVKGQWLQANKSLCRLLGYTPAELYALTFQDITPPEDLPA
DLANVKTLLAGEVESCSMQKRYFRKDGQILWALLTVSLVRDSEQVPLYFISQIEDISDLI
KTEKVNQRLMERITLANEAGGIGVWEWDLQSGVMSWDKRMFQIYRLPTNSHASYQNWVDS
LHSADRSAAVRAFEDAIKTTLPVDIEFRIETDIGIRHIRAQCSVVLDEKGEVERMLGINQ
DITPLRQLTDALHEEKERMHITLDAIDEAVISTDEEMRVIFMNPVAEKMSGWLQHQASGR
PISEILRITQGSNGPARENLMLCDLPLQKNPGEMDTELVLHNRAGEQFAIHYSLSPLKKL
TGENIGSVMVIQDVSESREMLKRLSYSASHDMLTRLPNRVSFEHQLKRLILSCTAQKQHV
LVFIDLDRFKAVNDTAGHAAGDSLLREISGVMQRHLRAGDFLARLGGDEFGVLLAECSLS
QASEAIRRIVQAVNEYDFLWENRTHHVGASAGLTQISPENSSASELMAQADLACYNAKHN
GRGQLSTYESHLLKRLKPVMNRIENEQIIAQQPMLLQVWAAAPPGRTLASSFYLAEMQLF
TPEGHEIDEVSFRTGLHDSDLFVALDRKLIREFFQNYAQGTISRGLTLALPLSGFGLRDS
TFINDTLAEFTRYNVPPDAIWFAINADVLSQCDEILHQNISRLRAAGSRIVLRDFGLNLD
AFNQLPADEIDYLILASELVANVHCNLMDEMMVSIIHGHAQRLGINTLAGPVKLPVALDT
LSTIGINTVWGDVIAPRQPLSALLTDSHFAIK
>A0A6N2TLK3|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MTHREKIGCMAADGSPIDLSEAMIFEWDIEQDRITCTQSNGVEVCIRDVCFDTDQADSTF
LRIHPEDIPALAEFRNRVRQGNLYSMSEFRWKDSEERYTWCRIYAIIRYDGQKKPVKAVG
SVWNIQKEKQRIQKLRYRAEKDALTGVYNREETEKRIKRYLEMHSDNQCALFMIDTDNFK
QINDTKGHMLGDVVLTEMASGMKKLMRESDIVGRIGGDEFAIFMKNIPSSQAAEKRAGEL
SEMFAHLFEDEKQEVQVTCSIGIALSRRMERILIPYTGVRTMLFIRQKSREKADTYCITK
RNLSVWMKQNILF
>A0A239SSS7|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MTTQFPPAHPPPSGPGSPVAGLLSPQASPDAATGAAAHESTHEPPAGAAVTPSTPPAALS
VRRRRPSLQRVLRRTHLRLAVSAVVLAALLLSGVAWIALRAYAENNLLLIGRSLAYTAEA
AVVFGDKVAAQEAIALIARDEDVVQVRVLDARNAQFAMWRRPDGGTLARIERTVADIAMP
GPVTLPIRHEDKVVGTIEVQGQGNQFFVFLMSGIGGVLACLAVTFGVANVLAKRMHRDIV
KPLRALAEVAHAVRRERAFHQRVAATPIAELKELGDDFNALLDEFEGWQNHLRAQNATLA
HQANHDPLTGLPNRAYFESRLVQALDEARELGTHVALLYLDSNRFKDINDQLGHDAGDAV
LVAIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRLAQNLLASMERPIALPDGS
ELATSMSIGVALYPTHANDAVALLRAADAAMYQAKRAGDGTWHVAESPKG
>A0A6N2TCV7|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MDKKKRLIQLTEGILLCCVIVVMTLLCIGIIKKEVKNTKGKLTETTGWYRIQDNKKVQVD
LNQKIKTDTQGKLVLYNDTIAQKYKGYLMTTKAAKYSVRIYAGDQLIYQYSDSNFHRNDQ
MKSKLSCDARIPEQGKKGTVIKIIYQNGSNGIYDLDDILVGRGDVVMGFHVQQEIVGIVM
IAIMFFLSFVALTTGIYLKHFKLNSTRFLNIAAFLALSGIWFLSDSALAQEYTSFPALTG
MISFYAFMLMSVPMVHFVKNTLKFEKYKVLDVINLLFYANALIQGILNKCLKIHMVHMLF
VTHVLLFIAVITIVVLMIEEYRRTKDSELKIIMNAFGIMAVAGVLSLCMYWKLEIPFYGT
IFEVGVLIFEQLLLTSIFVNLVEQAKTRSELEVYERLLKEDRMTGINNRTAFEEQLQDIE
DHAQDYDNAALIFMDVDGLKNTNDLYGHNAGDELIISAALCIKNVFATYGKCYRIGGDEF
CVLIFDSIENMDELLKQMDQEIIKYNRNNRYYLSITRGVSFLKDTEGKQKKISDWKYEAD
QDMYCNKKRRNINDRL
>A0A7U2ZVG7|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MLTPANHLTKRLIIYIFICILAGLGIAGLTAFFHSSLSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPIAFAFACSALLMLGTLSSYPNWWTCMTTPVVKHNDAVIYYFF
RNIMMALSFMSSIILYSFRQRLMHSWHARAITFTACIVFSLTIIILSWLFSSHSPWLNVD
FIDDISHTFTPLWQSITGWVLIFIWFITLVLLICLSKLRNIFWYSGAFFCSAYLFTLYQL
LSVTGDLDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLSKVNAQHPLSVLVSDLDHFKRINDNYGHVVGDKVIQFAASVLENHSR
VDDAAARIGGEEFALLLVNTGEEDAQSIAERIRIAVSVEQSHLPERMTISMGVYTTRDSS
VSAEECVQRADTAMYEAKNSGRNRVVVWRRQGN
>A0A0Q0JIY8|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MNLKSIINLGTNQQSFSSANRIRTMNIIGLITVAISFLYSLNYILFLDNPSVGFINLGFT
FAYFVTNVLTAKQQPKIAKIWFFSVLMLHLLVCTNVYVTNASGFHLYYFLVPTGAFLLFE
LRERLEQVTLSALAMVLFFYCENTVNEAPLIELSAQVNHMLYQSVVFFTMLEVIVVLYIF
AKQIDKNEKQLTLQASTDSLTRLANRHSFFTEGKSLLDKAVAHQLPFTLVLIDLDLFKTI
NDKHGHLVGDKCLIEVTKTIKALCREQDLCARIGGEEFVIAMPNTHLHDANKVAERMRGH
IAECKIPLTDSQNLQCTASFGIAEKTASAKELKDLLMRADKALYMAKENGRNCVKPYYDK
AA
>A0A0N8TXV7|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MGEEGDLELLNKYLAELDQLIPADDIKQREKLIPLQCWYHPSETTEEFQKAIKHAEVLME
AHQKSYPSELHADLLLCRGSHYQYSGKPEQAKLDYDAAIKEAYLIENMRLIADGRSMRGT
MLSYEGDYTGALEDLIPAQSMYEQLNLAYWARVNLSEIANSYRRFGDPQMALTYQLKLEK
AYLDNNQLVEAFDTNTQIAYSYEALGDNQLALERHQKSYQYWHQQKNSLSAAASAVDMAG
ILIKLNQVDEAVEILEQAENTITIEFDGIFSFMKLFSAQAALIKQHPEKALEYAEEAESG
FNVSNNDRGLSQLYTLRNQIYLSIKDYQSAHQALTDYLNVHHKLDQLSLTSRNSEMRARF
NTDKIEAENQNLLSIQLIKEKELAALEQNKRLQNIIIILVAIILIIVTIYAVKQVKRKQK
FKDLALTDELTKLANRRHTYALAKTYINQAKTEHRQFSVISFDADHFKKVNDTLGHDIGD
KVLIKLAKIAKELMRKSDTVGRVGGEEFLILLPGANEQQAYDIASRLIVRIADADWDTIA
PELKQTVSAGVTHYQNGDNFENMLLRVDNALYQAKSAGRNCVKTV
>A0A5J6W3H3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. E76|TrEMBL
MNDEQTFSKWRLWDISAREKPLNDDKYRSGLRFARRIWLPRTVGHFCCFIMFAGVLVDQA
LPGWWWLALVMYAFVWPHLALQIAERSSNPMTAERRNLIIDTLMAGIGIAIMGGNALPCL
LLSMMINMNNIGAFGVRFFAAGLMLQMMTALMAMQFIDAPLNLTTTPLQFFLSLPTLIIY
PALFGFVCYRTAVNLAEHKRRHQLISTRDGMTGVYNRRHWEQLLSIEYENALRYRRASTL
LLIDIDHFKQINDTYGHDVGDKAIIAVTQYLQLTLRVSDVIGRFGGDEFAVIMSGTSPES
AVAAMDRIHERLQNLRIENAASLNVQISVGIAPFNTHMKDYQEWLKAADMALYQAKKAGR
NRTEVYTVR
>A0A060URX1|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus ferrivorans|TrEMBL
MISRDEKSAPSELYDLLMDGGWMDVLQQHPTPQVITKNRKIIFINSAAVNLFDGINIESF
MGKDIIELIHPLDQERIFLRINALTKQNSQNAPTKIRINTVTNKIKYIISSNANQLTKLI
SRHPEDCLLVVVDLDYFKEINDRHGHLSGDKILKTIVSLIKESLREADIFGRLGGDEFSI
IFRNCTLSEGCDICRRTIKKIKDTKVSMPSKEKVSLSVSLGVTPLTAEDNPFVQALARAD
RALYLAKTKGRGCFAVSPLDGGEPFLPLHSESE
>A0A5Z8BXW6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9EFA1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V3AV23|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLHNGVV
DALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKNAQLL
RTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAGDRVL
IEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELHNGQR
ITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A763XHC7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLLIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>D7XPD9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 84-1|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSEN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A5T7VVM5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISRAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A157RS14|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MRRLDLRGLILGLSILSLLMALAGALYASVVVQRDIQLSQSLDHNRSLAQRMARSIDVFL
REGLNELSYAARQIGADDASAASVRAEIQRLKHQNGRFDAVGFVDARGQVAMLLPDGPGG
AGRRVRSAEMELALASRLPRISDLFLSSAGQWMLALSQPVFLADGRFGGFVVGLLAMSER
NALSDILGESREVGNGNHYVVDARGALLYQPSLRRIGQNLEENRAVRAVMGAEEGAQRLT
SLDGQDMLAGYALVRETGWGVIVQSAAESSLSRTQQLLTGILQTSLPWLCLSLLCVWWLA
NRIARPLAQLAGVAADLDKPRVGERLATVGAWFREAEQLKTALIAVSRKIGTKFHQLRQD
SLTDALTGLLNRRGLDEILQTEPRPGQSIAILAVDIDHFKSINDQLGHAAGDTVIRSIAA
LLRDRARASDILGRLGGEEFVVLLPNTERGQALQAADRIRAAVESFQALPGGACTVSIGV
AMYPHEGGTLTEVLECADLALYEAKRAGRNQVRSRLQAET
>A0A5T7KUK4|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A750KRY4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAVADTLATLGRQGQFAAAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSHPIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
HGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFARDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQEFNRPFELH
NGKQVKMTLSIGFALAWEHTSAEKLQELADRNMYQAKHRRTKRLLK
>A0A6L5BSQ8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MPLDPLTMLTISVALAAAAALYLAIEWRSIREPSLLFWSAGFATITVGSTLALLRSSGFL
LIGIWFANGLLVTAHFLFLLGVARFTQTRLSRGWALIFIAWLAMLLVPDGPIWSKVMLLV
NSLLVALSTLRASFLLRPHGKSLSVGAVQLRYVLLAHGVFYVAKALTAVIPGTLIDLAAL
RGAIIQISLVEGVMAIMLIALSMTGTERYRREKQIAHLAARDPLTALYNRRALEVRAPRL
LEDVSSTRPGALLLIDIDNFKLVNDLYGHTAGDRLLIALSEMIRAVLPEASLAARLGGDE
FVILLGNASNEQVVSLGNTLREQFQQTATQTFATPEPVTLSIGADLFDQPPASLAALIEQ
GDAALYASKRGGRNSIRLVDRTH
>A0A5T2VMG5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRSVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6L5BXJ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MPLRSPLYSQRSLVLTLIALLGAGFLATSFLSYYASRASIRDNIVNTELPLTSDTVYSEI
QKDLVRPILISSMMSRDTFMRDWVVNGEHDPDQMTRYLNEVMTHYGAYTAFFISNSSLTY
YHAKGVLKQVKIDEPRDAWYFRVRDMKEPYEINVDPDLANKDNLTFFINYKVYDYDGRFI
GAAGVGLTVDAVIKLIDKYQQRYQRSVYFVDTFGRLVLTGAEGGPEGARAGRSLGDLDSM
KGLVSQLPKPHSGSYEYSVHGQGHFLNVRFIPELNWYLFVDKREDGALSEIRQSLYLNLL
ICLLVTSIVLVLLNRVIKRYQGKIRAQAILDSLTELPNRRGFDLLAAQAMHEAQREPKPL
TALLLDLDHFKVLNDTHGHLAGDQVLIGFARDLESCLRHSDIVCRWGGEEFIVLLKDTDG
ETGQKIAEKIRQHVEKQRYAYDGKELQLTVSIGLTTLQPDETLHTLLSRADHAMYRAKQA
GRNRTCVEMPHSVYD
>A0A378CSK2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MQIPEGLSLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGSLFGTLCA
TSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELTQLPNRRA
LFKQLALRFASARAQQQQVSLIFYRSRWFKAINDRFGHPCGDSFWCRSANDSPLSRAGKI
SLAALAAMSF
>A0A623SYP6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINGKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A238LGW4|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MIRSTSHALLVSLCVFMGCNIGIDLMALVVFEREMWRPVVLFILGVSVFVGAPMTLIMTL
SMMRSTKLTEELQILLNRDRLTDAATRHFFFERMEAEPNARGVVLMIDIDHFKSINDAYG
HLAGDSVIRSVAQVLSGVAAPDDIVCRFGGEEFLIFLNARGRDDGLAIAERMRLEVERNT
FDIAGKIAGETVTVTVSIGGALKTDAIEINRAIADADAALYRAKAAGRNATLFAPLLESQ
AA
>A0A0T9KYZ2|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MTLSSLFNDACVTYASLSISYFALSKNTPFSYDGEKWKRLLFGLVSGLISLYLNQDKFII
TNSFFYSFEILPIILATFYGGWLSGLVALAINIIFTGLFTLDNMLIVLIIFPLLLSKVWE
RKSNRVFYITIALIAVYRTCVGATFLNYGQLWPSILIYQASSALCLAICFHALNFKERHI
HAYFAMKDRANVDNLTRLNNRASVDFRLNQLSTLRRACGLLILDLDKFKTVNDNYGHGAG
DLILSSVGEILKQTVRSLDFVGRFGGEEFIIITESHHPESMKVMAERIRESIQQLEVTLS
DGRKVRITISIGVSLYLPGMSMVKAIKMADDALYQAKRQGRNQVVYSKLMPFSPLGDRTR
GVGKRQPRRNNPL
>A0A2H5ZA30|diguanylate cyclase|EC 2.7.7.65|bacterium HR29|TrEMBL
MPMLQRAANTVRRFIHPAVPEEELGTHARRYHTLTLALLALAVPLELYLAWRVPIPGLAL
LLATCAALLAAERGRELSWRERQQAIESEVERQADALLRDGQTGLPNRNYLIDQLTREIA
RAERYGTTLTLAVIELARADELQRSWGGDIVSRAAVHVAETLRRVTRASDFLARLDEQRF
AVVLLECTREQAVRFADRITLAVANRPLEPAGRQRVPIYIAVQVRATQFERERFRGPLDF
ISAAGGDVVIDPPSARANETVDVRAIRRRALGDLPSVDSTQEFADAWRAYRARRRLG
>A0A0L6CTZ1|diguanylate cyclase|EC 2.7.7.65|Roseovarius tolerans|TrEMBL
MPWEVRTRQDEIRFTLVVSLIVLAASGVLRSLMLPPELAMPTLVPGAAMAVMIAAPIGWI
IARHLRAVHDLSARLEHALHHDLLTGVRTRASFYEAARALEDQPCVVIVADIDHFKGFND
CHGHFAGDQALRQFATLLAGNCRGGDLVARFGGEEFVIVLRGTGADQGRAIADRLADRVR
ASPIYVGERSLSLTASFGVAAWTPGGDMDHAIQQADGALYRAKNSGRDRVCCHHPGPEGA
APLQAVS
>A0A848NBN9|diguanylate cyclase|EC 2.7.7.65|Achromobacter ruhlandii|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHEGMKGWLRGLLCVREQGDIAALMAIQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPSLLLVGPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAINDQHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGREAALAVAGKLGAEIRRHAF
SIPEAGGLRITTSIGVATFDGHPDYAYLIDRADKALYQAKQSGRDRSVAA
>A0A2S0XGY4|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MRASLKKLSWSAWLQLAGWTVFGTLGCVAFSLAVTFVLFQNAGAEVFDLVLIEATVVPIL
LAAPLFFYLTLKLRELAIVNHKLVVAASTDALTACLNRGAFSSRVNDVLAREIARRNQRT
MGALLVIDADHFKTINDSFGHAEGDVALRVIVAAIQPCLRSDDMLGRLGGEEFAVFLPGA
SPVNAADIAERIRRSVAEAPFQPAGRLHRLTVSVGGAVFNSPVGFEELFRVADLHLYEAK
GAGRNRVELAPMPPDLTPGWLAPSLLN
>A0A377FRS1|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MRFRKYLVRSWLSWSLVFAGIIYSTWQSMGAFEWTLFWFIYTLGALFVMNPLKRRHLHFT
FHEMFVFMTFFFYGLVPALIMGQLLLLTFQARSFTKRVGRRRFLHFYPLNTLIEAMILLI
PGLVYLRLGGQIGPSVHLLEQGMALLAFFAVLYLVLGFSFVLSRFLIGERIPLPIMWRLL
RFDWLVVSLELLFTMVAIEAYQLFGYVGLMTTFLLLSLLKMSLSKATETEETQTKIDQIE
RLKEQLYRVDSETLLIEKFWNGLREIVEVERGWLQVNRDSSRTFYDMTGRADRAVPDAYT
LERHRDAGETYFLYDSLHEWHPELLVHQTELHQSALVIQPVRSTTNAVSCMISTTANGAY
EEALAVEIHRLLKTLSWSLERIDERDRLQHESLTDPLTALPNQRALRRWTKERMNDVASY
PLSVFLVDLDHFKAVNDTYGHAFGDEVLIEAGALFTRLVRTGDLVTRYGGEEFVFPRTNE
QAAILTGEKIRQALKAHPFGTEGVRINVTASIGVETIHEYEELDTVLRNADRAMYVGAKF
NGRDRVAHYRDTSTERIQ
>A0A377FWX9|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MNHFRKLSALGWGIWSAFVLLTITLFATGVLNAPAIEPLPFILIALLVIIFQLDSIERKG
VYFTFSESIVLIIFLFFDFETALFVNQIGLLVFQFVNLKPRVALRRFRFTYPWNAITSFL
ELAIPASVYLALGGETGLGFYTQDSFLPVAGLIAAIVLNTVLQKYQVGWWFRVDVPVRDF
LSIAFYTYIVSLVFIFAASFFRETNLLVVSSIAAALTFFIKRLLIQKGRQDAFKSLIEQY
DEAKEAVSLSQSEAQAIEVFLSQCERLNQYDAGFVEFTLFDRSLYFDLKTRQPIERPRVF
DLLESTYPNESSVEYEMRFEWDAPMSDEFHDDYHSFISVRSEEIEGIRTWIVMAGEHVYG
YPLIIQREIVKLLKSFNRTISRCHERDRLYTESRTDSLTLLANARAFYEYGIQQISDASM
YPISVAMLDIDFFKKINDTHGHQVGDGVLQEFGRRIRQALRTDDFAARYGGEEFILLLNH
CDVDQAVEIAERIRQKIEDKPFYVDGIAIQVTASIGVDTIQAFGDKRLDDTIRNADRALY
VGGKYAGRNRVAHYNYLTT
>A0A7W6DSU0|diguanylate cyclase|EC 2.7.7.65|Sagittula marina|TrEMBL
MTSRILVVDAVPTNRIILRVKLSAAYYDVVQASSGTAALDMMRTSAPDLVITASELPDMS
GRDLCAAVYEKSARRRGPATPVIITHNANDKAERMASLAAGADDLLERPIDDLVMLARLR
SLLRARDAEAELRLRDDTRRALGLEEQAAEFATPGRIRIISTGHQPEMSTLVHQLQQRTE
HRIELVGTDDPLKTAARAPDVVVVAEAPGTEGTGLSLLPQLRANRSTRHCALIYVAQSNQ
RREAATALDLGANDLMVNGFDVEELSIRLKKQITRKRTNDRLRANMRDGLRAAVIDPLTG
LYNRRYALPYATRLAERTAVSRKPYAILLADLDHFKHINDDYGHSAGDVVLATVARRIKD
NLRAGDLTARWGGEEFLVAMPDTNRQIAQRTAERVTALISETPITLPDGRNILVTLSVGV
AIGYGADDLPEELIARADNALYAAKHQGRNTVVMADTVTALPPREAPKAEYGPMDDLPQT
GTYGPALPKLRHS
>A0A0N0GLQ5|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MSMQLAPASPDVAQLLAQAEALYLPQCELSLPLAEQAAHLAATLGDEAGEAAALWLWGRC
LNVLQGGEAAQPVLRRALTMATHLDNAFARARANHALAEALASGGDDSRALSHWLDCLED
ALSTQQIGLFIEATLGLGNLYVIHEDHENAFRYHTIASDFSRLHDNQDLRAKAALHLAAD
LIKLDRLPVAESVLRRAQQDLILPLRRDWLAEIHNYLGAIALRQNQFDAAREHLEQAYQI
NLDTGLMWGQIVNLTGLGKLLLRSGDGQTAERYLLQALKAVEKLHAPHLVQDIHEQLALL
YEQRGDDVRAVMHYIGFHEHYMQRVNQGVAGKLAQLSSRRLANLEIRLRLLGSEFELNRL
REANRETDLRVQALQDAAYRDALTGVMNRRALDESLPGMIEAAQQTGEALSMLVLDFDHF
KLINDRWSHQVGDQVLRTGATVLQASLREHDLAARYGGEEFVLVLRNTALDLARNVAERI
RARVETEAWHHIERGLQATVSVGVAQWQSAESAGAWFSRADAALYDAKRRGRNRVSVAGA
DR
>A0A0F0CAM9|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MWMKLKCLLGIDAGLRDFDEIECSLHRDVVNRNFFFHLFIIIYELVMLVSISLRPGGPFL
KPRRTAYFLMYLILILVTLCVMAGQAWVDRKKENSHRYYFWIEHAYLVFFSFWGIAVTLN
DQLGGNGLTVYNYVILILAILSMMKPWKTALLFLADVLVFNLLLPYFPDPAGLNHTYNNL
MNSLFLSLVAIGIATSLYNSRIQSKKDEITIRRQYQQIEAANKILSKEALTDALTGIQNR
NSYKKAIRTLTQPDTLSLACVYIDVNGLHEINNHLGHKAGDVMLKTVAAILLKNFGRESV
FRIGGDEFVVLCRDVLHQTVTENLEDVRQEVERAGYSISVGLEWREEGLDINEIIQAAET
DMQMRKEEYYSAQGGERQQRSLDSQMERVITEKRDAERFLRVLAPVFKGVYFVNLETDTL
RRIFIPSYFEKMLEESRDSFSKALLMYANRMVEPEYVRLFEQFCDYGNLEMMLDGDEIPG
FIYQKRDGSRLKLRVLRCNSYFSSSQETLWIFSDMEESY
>A0A0F0C779|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MKKRLLSNRVRNAILMAILLQSIIFGIGLVITGTFSGTANRPYKVMESQVAEKNSLLSSY
MNNVLLLANTMEKELAKMTDEVEIQNRLVDNLNHASSSDGIFYIDLDGREALVLHDGEPD
IYSSTYGDISCTIGRTQSSYPIALSKDWRPKLTDQEWGMVEQFWENKGNGGTWFFTSERL
YYVLSQESSRGRRIMGLEISSDMLDSCLKLDNPPYQGMTMLLLSDESVRFSLDQTFEGTG
YDLEEKTGYISLTNNGVGYDGVRSALQTYGYMYGGAVYVAAVCHHSELTALSQSTILMVA
GVYLLSIFIAIIFSYIAIYMVLKPIQRLQEDIACQKPEEVHFRESGIVEIDRIHQALNDM
ADKLEQSYSRYSFTMESAGDNVGSFEYQEKGGRVKVSPSVRILLGIPADSREPVNEIDYD
KWSRILGGLEQIEELEDGYAFTDIYGDRRAVTIRQRREEHGVFGLVIDKTDAYNEIVRLR
NISQHDQLTGLYNSSYLKKEGQKILDENANRVNALVFCDLDNLKYINDNFGHEMGDRYLK
AMADLLTSMTQGEQCIAVRLSGDEFVLFFYGYDNRDVIEQKVRDGYAGRPSLRLPDGTDH
RINASIGLAYAQRETESMDGLLNRADRAMYRVKHGEKNGIAIYDKSDEAGPA
>A0A8F9TDJ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MNDLQLDDFKTDENAAMVLLVDDQAMIGEAVRRGLAHEENIDFHFCADPHQAISQAIRIK
PTVILQDLVMPGLDGLTLVREYRNHPATQNIPIIVLSTKEDPLIKSAAFAAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYLELEWRRAMRDQTQLSLLMIDVDFFKTYNDSFGHLEGDEALRKVAASIRDASSRP
SDLPARYGGEEFALVLPNTSPGGARLVAEKLRQAVAALKIPHIAPSEGASLTISIGLATM
TPLLGTDCRQLISAADKGLYLAKHNGRNQVGIE
>A0A1Y6KSX0|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MDRKQKTIIFLIVTLVITIIGVAIIENINSTYNKQLIHEVNNKAKENLAALRFELESALV
NDIYLTSTLADIATIDFQNRNEVLNKISEAVILKSGHLTSVGFAKDDIIDFVYPFESNAK
AIGLVYKNKPEQWKDIKKARMTKQILISGPISLIQGGKALIVRVPVFYDYPNKNKYWGVI
SGVINYDKLFETLTSMKNFEKYDLSIVDVSDSRQTSFIYGQPKVIDNYLFYEEVKLPYGK
WGIYLSHSKHNTDYFNDNVRIIAYPLLFCFIILFLSIAILYITNEHRAYHDALTKTPNRR
YLIKKLAKIFKQAKLGNIDGTFIVVNIDIDKFKHINDNYGHAAGDKVLTVLSKRIENNLR
KNDIVARMGGDEFLLLINFKNDSINIKDRVINIVNDVTQNTILFDGKQIPISITSGYVVY
DESIANFWDMLILADKSMYNKKTY
>A0A517T0C3|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium SV_7m_r|TrEMBL
MNPELARIIDGENMPSPPTVAAKLLELVDNPDTGLNDISRVISVDPKLTAKTIAYCNSPL
IAPVKKVTTLQQAVTLLGIRTLKLLALSFSVMDTRSGRAFPNENFWRRSLGIAIAAKVLS
SAGDQDDDESFLLGLIFNVGVMAIGIAFFDRLVQQFDADEFLEKLTTELEYELCGHDRYF
VGARLLERWHFPDRMIQIVESYDPNRLTQDHMGLFVAQQFSDLLLAAESTEGQILKVRDS
AKRYLDLSKDQFDEMFDNMVQQWYGYQGLFDFKSLKHASIEDMEAKARESMVRLSLGMEQ
TIREMHTEQEELRDLARTDNLTGLLNRTAFDQDIGPLMKGYQERSESVGMIVADIDYFKQ
FNDRYGHAAGDNVLCGVAAKLTELCRKHDHVYRFGGEEFVLMIGECDYAAAATIAERFRK
GVEQMRVGYNEDLLKVTISMGVCWIDSAKLTDVEQIFKQADACLYEAKKNGRNCSVARKA
QDSMGCTVS
>A0A1S8LCH6|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MNILSMLSFTNFILFVRGALYSFGHIRKSKLALPFMLVFTSLAIWCFGDTFFYTAPTIAN
AIFWYKLAGIGWVTFPATALHFFLLLTKFINKSKQKKIIIAIYIIPIIFLTKNIFSSKLL
LAVTIIKNPAGFGWTDIGSNDLWFWSYSAYLITFIVYGLLLVYKWGKLSPYFSEKRQAWA
LLIVSSITLIIGVYTDILAPTIGIRLPPISNIIIVLLAVTGFVAIQRYNLFSDANTVTAE
TILNTIKDPVLVFDANYKIIKINKATTDLLGYTFKQIEHKELSYILANSDYDEFKKKLFL
SNKPFKYQEATLLTSDCRLISTIYSTSVAKNKYNEFLGYIITFKDITDRKAIENQLRISN
YKYKKLVFNLFKAANYDLLTGLPNRRVFFSKLSKLANSYKRHKQDFVVIYMDLNGFKQIN
DNYGHDIGDYILKTAANRLKDCIKKPEILSRLGGDEFVILIPNSPSKLIIDDKINMIRKN
FEANIKVGEKSLNIGISIGYSTFAICNENINTLVKTADSKMYSDKLKNKNIRV
>V6F8R7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MDPIGNIIDLAFERRKRGPRFNGEMMQILEVSRDLICLCRGGAITAINGAGARMLGAKTT
EQLIGRRLAEFLIPEYGQVLDLFLSGMASEDRGVPTRIVGLDQAVRDIELQVFRAREIAT
DATVVTGRDMSKEGKLAGSAHKTDTRFHLLVDNSMNLVCHVVGGSIRYVNKAGIALLGAT
EAEQVIGLRLEEILHPDYADLIGDIAKEGAAVPLRLLHRDGSAFDALVRLTELPAGGMGT
ELMVEARDITGHNRAVAALRRSSETLEMRVAARTRELAEQHARAEEMTLVAEAALRFSES
LIDTIPSPVWFKDALGRVQTSNRAFRALFGDGEPKLLLPLEDTVTDAELMSGACDQASFE
APILPPSGGRLDTMVLKSAYLDDEGRPVGVIGVLTDISDRKAMERELRRLATTDSLTGAF
NRRHFLAAAGTELERANRYGNPLTLLMLDVDYFKSINDAHGHGTGDDALRRLVEGLRHAL
RDIDVIGRLGGEEFAVLLPETGMAGALITAERLRAQVADLRLDLPDGGQLAFTVSIGIAA
PRAEDGSVEAVLARADKALYRAKDEGRNRVCAEVVDPD
>A0A158S5T4|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. KN65.2|TrEMBL
MTNCIAIAGRFFGSLEKRLIGAMALIVALTLLLQFVSQREAFGLQRESDALVRASALAEN
ADQFAEAVGKLRTATNRGLVASNISTTSDALTDAAIAIGDRLAKLRDSGTVLSDLQTASQ
LFADLDQHVSAILKVQTANGGKAALIAKVEAKNAAMETLATQVVEKAHAHRQAAQARLVT
SIERWQFLVLGTGGVTILVVLIVLFDLMRNILPAVRRMHRALQRLADGDLDIEIGEFRLK
ELQALSGPLETFRRNAKAVKNLAFTDAATGMPNRRAFQEATEKLLNGSKEGRFAFMLIDI
DRFKHINDDYGHATGDELVRIIGARMKDFLGERSVVARVGGDEFAVSLPLTRQASAIAMG
SALVEAMREPFSLGEFSVASTVSLGVVEVQLPTGSDVDAILRNADLALYASKKNGRNCAT
AFAAHMAEERSIDRALEKDLEAAFDAGQLRMVYQPIHSIDEDCREVEALVRWKHPELGEV
PPSTFIPAAERSGLMVRLGEWIIRRALQDFAQWPDIQMSLNLSPLQLQHDGFSTFLLDCC
RQNGIAPQRLFLEVTESLSIERNTRALLTLNLLRNLGFRIALDDFGTGYSSLSMVKSFKF
DRMKLDRSLVMDLGQDPASLAVLEAAVTMARHVGAEVVAEGISEDHLVGPTRSAGCTHLQ
GYFYSRPIEAGHVSSYIAKVQGKSAKAA
>A0A840BQC3|diguanylate cyclase|EC 2.7.7.65|Niveibacterium umoris|TrEMBL
MVQAKVYWVTPDGIEHADEVRAAVLRQAGHDVRCVAPGLQSQYPDAVFVIRADLLIEPAA
VKLALPAGGLPVVLIISDAAAVEDYFALLDQRPEADSLHDVLRAADVEEFLAWRVWRLTE
LHRHRRAQLSRVNHDSLTGLLRRSTWQERAEKLVKTCVGSTTTVGLLYLDLDHFKAINDR
YGHAIGDEILLFVADCLRDWFAPDDLIARLGGDEFVVMLRRDDELAVANDARRFVAHFCT
IRYPISPGAGEGGERARARNRGYWRGTQAGGAAQRAPLSVSGGLTFVRGQLALDELVEAA
DLALYRAKSEGRGRLIVVDELAEVLASEGKDLRVDHFENVTRVVTERVTSLITLMGRRLM
NEATRDAYRDALTGLHNRRYLDEHVERELEAAQRNHRALSLVFLDLDHFHDINMTYGWPT
GDSVLRAFAGVLERSVRMIDWSARYGGEEFCLVLPDTLLAEAVEVAERIREHTEALTIVS
SDGRPVKVTTSIGVVQRGAEMRAVELFDRVGELALAAKQRGRNCVVSPLNLALAG
>A0A7L6YDZ8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C01|TrEMBL
MNDDNFYKNHIAPDEGGYISLQHDLQRSGLRFARRVRLPRAVALGGMFFPLAATLVSQPV
AGGWWLALVGWAFVWPHLAWQIASRASDPLHREFSNFKIDAIFAGVWIGLTGVNALPSCA
LLMMMGMNLMGAGGSRLFFAGTVLMTLSTLLTLQLTGGVVSFSSTPLEGGLTLPIIILYP
LLFAWVSYQTATTLAEHKRRLKIMSTHDGMTGVFNRRHWEMLLRAEFERCRRQHCDCTLL
IIDIDHFKGINDTWGHDVGDEAIQALTRQLRMTLRSSDLIGRFGGDEFAVIMHGTPAGNA
IAAMSRVHEGLRALRLPCAPQVMVHISVGVAPLTPQFSHYREWLKSADLALYKAKHAGRN
RTEVAA
>A0A7W9BM32|diguanylate cyclase|EC 2.7.7.65|Loktanella ponticola|TrEMBL
MNSLLQTAEILVDPMLLAIAVIYIYGFIVRLTPNTYVHQIVMGVTFGVGAIFAMLMPITF
ADGVIIDMRNLLIGLSSAFFGIPGAIIAGGMGLVTRFYIGGSGAIAGMTGIAIATCAGLF
WAHFVRGKLKMQGFELVLLGLLICTYLLAVVLLPTTIMWSAIYELIPVLIVFNVVGTVLI
GSLMIREEGLAAENAALLNAATTDPLTRLQNRRSAVAAYNALPIPKNSRHGIAILCFDVD
NFKIINDTYGHVWGDKVLAEISDRISKTLRPTDVFSRLGGDEFLIILPAVTEAETQQIAE
RCRDVIAQTDIADAGETMNVTISVGAEWLSERPDFLTFVARADEALYHAKKLGRNCVSFA
WLNTATAAQAFSQATQNRTA
>A0A653VC14|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MASCHAQADIRSRIAEAERVANTDSQRGLSLLDALARDVAQGPLAERQAVRESTCWLLGQ
SAPAQALELVRKAEGEATAMLRLCGGYALEQLDRREEALAEYEAGVLAGRRAGNDSVLAR
ALALRGEQRYVRGLYAGAIEDLKAAHALQARLDEPGQRRYVLNALANLYADRNVGDYDAA
LASYRDLLVEHEKSGNRQNIATAHFNIASTYEKKGNLGAARPHFEQALAIDRARGAAADI
ATDQRAYAVLLSKLGEDAQALRLLDQALALAAGDETLVSAIRLSRGAAFRRARMPVQALA
EFSAVRRFYEAPRNERFLQKLFEEESLARAAMGDWKGAYAAQGRMMAAQEVLNQQMLDER
TTRLRVQFQSEQARARNTELQYQNSVQRLELDKGRDVRRWQLAALAASAGVILLLAAFAM
HQRRLGSRMRDLALTDELTRLPNRRHLMALGLRVFSDAAPLSVAALDIDHFKRINDRFGH
AIGDLVLQRVAHALQAALREGDVAGRTGGEEFVALLHGAGELDAMRAAERLRSAVERMDC
SGLPAGLAPSISIGVAQRTPGESLDALLQRADQALYAAKEAGRNRVSMAA
>A0A7W9BM65|diguanylate cyclase|EC 2.7.7.65|Loktanella ponticola|TrEMBL
MAPKNVGHKSSFPTSQPRACSAIVSACSGLIRVTSFVRNNILTFPRQVEHRGRVEQALLE
GNTMSGRILIIDAVATNRIVMKVKLLSAQYDAVACATQSEALATFSEQRPDLIVVNLSDQ
TEDHHAFCRNLKDDPATASISIVGTGIADTSRARFAALDAGADDVLTNPVNDVLLHARIR
SLLRTRHTPSELWMREGTQRALGFEESPTGFERPSRITLLTANSVLSTGLIARLNRINPL
GVAVVGFDAVLKERSDMEQPDIFVIDSNTMLNPREDLFRLVADLRSRAQTKHISQLVSLP
ADAVETAAMALDLGADDVVTSQIASDELCIRCTALTRRKRQQERLRTTVRDGLQAAVTDP
LTGLYNRRYATPYLMEIAKQSKKTGQEFAVMMIDIDHFKRINDTHGHAAGDAVLIELAHR
LRGNLRAIDLIARVGGEEFLVALPHSTAEQAQAAANRLCRLVNQKHFDIGNKSRPLHVTI
SVGVAVGCAESTEMICADDMCHQADDALYVAKSAGRDRVSFAHSAA
>A0A0P8WUG3|diguanylate cyclase|EC 2.7.7.65|Oxobacter pfennigii|TrEMBL
MKEIIMPEIMQKAPISYAYHKVVYNREGIPDDYIFLDVNSAFEEMTGLKKGTIAGKKAME
VLPGITNNSFDWTDFYGKIALCSEGQEFTGYMDFMSRCYKIIVSAPQKGYIIIFFLEITP
EIERIKALEKQEQRNKELAAELEMVFNSTQDAMFLVRFENDEFRYIRNNAAHQKLAGYSL
EDIRDKTPFEVTGEEIGKILISGYQRCVDTRSPITYEETLPFPAGVRTWLTTMTPAIENG
VVKNLIGSRKDITIQKHAEEERKELFNRLQAMFNEHTAIMLLIEPVSGKIVDANPAACAF
YGYTKEEILDIYIQDINVLSEEEVEKRRLIALREKQRYFLFPHRLKSGETKMVDVYSCPI
THSGEKLLFSIIFDVSDREKYKEELYWEKELLKTALLSIGDGVVTTDEKGRVTVLNKVAE
EITGWREEEARGRPFEEVFELISEDTGKKVEDPILKVLKTGKIIGLANHTILIAKDGHMK
PIADSAAPIKNEKGHILGVIMVFRDVTSEKIWQKKILDLSYHDSLTGLHNRRFIEEHMKK
LEASQDLPLAVIMADVNGLKLANDVFGHEEGDRLLKKAAGILKENCRKDDVISRWGGDEF
LIILPKTTNEIAEGIIERIKNKCPEIKSIKTQLSIAMGYAVKREASERLDHVIKEAEERM
YRQKLMEGKSYRNALVSTLLATLFAKSMETEEHAERLKSYCLAIGKEMGFSIKEQDELSL
LAVLHDIGKVGINENILQKLGPLTTEEWEELKKHPEIGYRIAQNTPELSTIAEYILYHHE
RWDGQGYPRGLKAEEIPLLCRVLAVADAFDAMSSNRTYRKAISRMKAIEEIKRNSGSQFD
PKVVKVFLQLYRKETPEVSDKKD
>A0A653J844|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MPRRILPKFAPADAPGSADEDIRVGRERSALHFGSLRARIAAILASLFGMLVGTLVVLFA
AGIVRIDSGPIGATVGQSALLLLVIGAAELALVVVLGIALTRTITLPLADLLRATRSVTR
GRKAHVQVETGDEIGKLAASFNTMVDAIETRERRITHVALHDALTGLPNRQYFVEQLDQA
LARRRDGTRVLVAYIDLDDFKMVNDTLGHAAGDRLLCDVARQLQAELPEGLIARLSGDEF
AAMIPAIPADADIAAFGMRLQGCFARDIVLDGRKAETSASIGIAVAPEDGAEGSVLLKNA
DLALYRAKQQGKAGHHFFETALDERARHRRQLELDLRAAISGGGFALHFQPLYSLSEERL
TAFEALVRWPHPTLGLVAPNDFIPLAEETGLIMQIGEWVMREACRQAMAWPEPLSVAVNL
SAKQFLSPALPAMVVHALAASGLPPQRLEVEITESAFAANVEKTLETLHALQGLGVRITL
DDFGTGYTSLSHLRLFPFNKLKIDQSFVHDIAPTGNAHAVIRAITTLADALGIETLAEGV
EEPSQLAVLRQEGCQQIQGYLLSRPIDGREVGAFIDDQRARAQVIRLRA
>A0A445N5D7|diguanylate cyclase|EC 2.7.7.65|Streptomyces netropsis|TrEMBL
MNALLTASAAAGPLVAGWSLHTLLLRRRVERARRDPLTGLPGRDAFTATARRRLRAPGGV
VVLVNLDGFKQVNDTHGHAAGDEVLASAAQRLAVWAETRGGCAGRLGGDEFAATIACPEP
SDLPFELGALGLPHRPPRGGQVHRGSDARADHRGHER
>A0A653INC6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MDRRRVSNAQQPTRTPFRWWAPAVLPAAVYRDLVAPLFTMRMPILGFGILFAFVSGLIFV
RWHDPIILALGASAALVTVVRLLVISRFYKAGGSSQPVQALLGWERVYTALTFVFALLLA
GLNVRVLMVHEPLMLAATVSLVFTFGAGLVSRTACRPRLCTGSLLIAVLPTALAMLRHVG
HPDGQALHGEFFLLLSFLLVAVLGMSLDSVRHLYAATLEQLITKHDLAKLARVDALTGLP
NRLMLRENYQARLEMAERSGTQLALHFLDLDGFKAVNDQAGHPAGDKMLREVAARLQGTV
RADDVVFRLGGDEFVVLQTGVAHRDEAELLARRIIKQLSEPYFIEEREMRISVSIGIALA
ATMESELDDLVGSADAALYCSKARGKAQLQFSDGERAANATVARVNLKEAAPAS
>A0A0J0KM05|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MSQPCFDALNVIKTPVWLVSPVSEKIIFANVSATQIMGDKTLDDLRKGIYSASAQTVLSM
YVSELKTEQEIVEIWTTSRDGQDTPLSCRLSLAHYAPWGDVIVFEGISQQILSGLKASRS
ANYRRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDDMCSKHTWEIN
TLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELEHAALRDSMTGLLNRRQFYAITDQSNLNTLPAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSREGDMVFRWGGEEFVILLPRTSLDTAMQIAESVRAAVA
RITIPGLPRFTVSIGVARHNQGESIDELFKRVDDALYRAKNDGRNKVLAA
>K8CCY1|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii 701|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLAGPQTDALIAGFKAERDKPEWTLPTGRDLAPEIQ
GVSDAFIGQSTLLERDDALLYSELNATLALGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTASIPLDDK
GRWFGVLAMDFPIGAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTADGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A0M6ZIG8|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MGRRLTGKFAFTSNGAWVASVVAIICFLTGIAVTAHVGLLVRNELVSQHKQTVRTELSEA
RARLEGEISRIVAHGLGFRAFLAEFNDRPFVPADYQNIANELFAENPAIRSIGLAPGNIV
RAVYPMEPNQAALGLDYRSNASQWPAVERAMNSRETVISGPLQLVQGGRALLIRIPVYPA
AFADQPLKDRSYWGVATLALDEETLMQASGINAVVNGTSLSIVDGDAGDAASKVLFGNLP
PEGTDFVSLPLFLPGGLNWKLLGYPKEGWSSTGKQVWITQFVGSLISLIFGVMAFLLISE
IYKVRSMALHDPLTGLANRRLLEERMYQLAAMCERSGVGFEIFYVDLDAFKPVNDNYGHS
VGDQLLIAVGDRLQSQTRQYDTVARVGGDEFIVLTPGSMRRLEREAFVTRLSERVSKDFE
FSGTFIDVRASIGSASFPKDAMTVEDLLRVADGRMYAQKAKSKQASADIREDGVPQAG
>A0A554XPC1|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MGSPASTPQEIAREAVKLLTARRLPPTPDNFQAAYHEVAGTRPLQPFPLAQLRQIAQALP
ERTPAQVRFKALFNKAVSRHSWDDLEKLLTQNPLASAAPAAAPEPAVPSAPSAPPASAPG
SEGALLPPDLAEQTARLIDVGLPLVAADDARLREMGEELVRYLRLEQQHAPTLRRMLADY
AYRLSFGVEEQLGVRQGLLGLLRQVFEHIDAISPDNPWLRQQMQALVQAAQPPLSQRRLE
DLQSRLKDVIVKQAEAREQTVRAQALMRETLATFLERLAQTATSTGQYQAKFEACAQALE
RADSLADMAPVVQDAIQTARAFAVDTQRVAEELTELRDRADRAEAEVQRLRAELDQMAEL
VTHDLLTGVLNRKGLASAIDRETRRAERTGTRVCIALLDVDDFKRLNDTLGHLAGDAALK
HLADVARRSLRPQDTIGRYGGEEFIIVLPDTTPEEAAGVVQRLQRDLSAHLFLQGEQKVL
ITFSAGITELRHDESVEAAIARADAAMYRAKRAGKNRVMTG
>A0A891SS05|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H-|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8F6XMJ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQSNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3LXK2|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo SFn135|TrEMBL
MKRKFLFTPFLALLAVAFTTALVTQSTHLLVKKSPLAEAAAEIKLNGTLAYLWFDEIMSG
DTAQSIQEVWYYLEIADWHVVALLEGGESITGSYQPVDDPQLRPQLVALREILEEFRREA
EANYRQLQSKRSAVHSLQRDEHFLKFASKADDIQRFIKSSYESGIESYTHTSVTLILAVI
VIAIYAIRLQHKHERSRDLLLTSLTDAKNAIEEKNVQLHNRAYFDPLTHLANRTLFLDRL
NQSILKAEHAKKSFALLFIDLDHFKDVNDQYGHQVGDHLLQKVAKRINQCIRTTDLSARF
SGDEFVVVLDHLQDIKTAIHIANKTASKLNHALSQPFQLKNHNVLISASIGIAIYPEDSV
TQDTLIRYADNAMYHAKGMGKNNFQFYSNELNRIAMSQKKTERALDVAIESDQFELYYLP
KWNLKTEEIEGVEALVRWTHPTLGLQYPDSFVPVAESTGQIRLLDLLVTQKALAQQKSWL
TEGVDLGVLGVNISARSLKHPEFFEQLKTLIMESGVPPQKLEIEITETVMVEHIEFAQTI
FSELKSLGVRVALDDFGTGFSSLSYLKDFDFQTLKIDRSFVVDYATNTTSMVLLKSIIQL
GKELGVSVIAEGIETAKQQQDLHDLGCLTGQGFYLTPPLPAHALVERLLNTPNHNIVPIE
AKT
>A0A2J7S4K8|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MLANSRSVKGRYISFCFGCLVVIGILQALFSKLVDWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLIAISFAFAGSALLMVGTLTSFPAWLDLYQFNVVNYNDAMIYYMF
RHLLMAVLMIVSALLYPTRNLPLSRLAHIIIVSGSFLFTACMVILAWMYSSHSPFLSLDL
VDNETRQFMVLWSHSINISLIVLWVVTLATLMFITRVRNLFWVGGNFLCVCYVVTLSMLL
VGGHAEDISWYRARLFETVATLIIIFVLLYDVFRLYRDSHLKYQQSYQNSIRDPLTRLYN
RSYFYESLNQALGIAKPSRPVSVIVSDLDRFKRINDNYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLANTSAEDAYQVAERIRLKLSGFDKISSEGQLPEPITISMGVFTA
TSSSVSAEACVESADKAMYEAKETGRNRVVVFK
>A0A379W4N0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MKYNVFAQRYPRRLIDLFELHNGQRITMTLSIGFALTWEHATAEKLQELADRNMYQA
>A0A5H7FZB9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Meleagridis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
TLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379WYP6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MCGTPADSAITAMSRVHERLNTYACRRAAGHVTYQRGRGAVNAQIGHYREWLKSADMALY
KAKNAGRNRTEVAA
>A0A3Y2DPJ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNCICASDATQEREKK
>A0A3S4I544|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNYSHDIPGGLRVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENIS
DAMTGLYNRKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLA
KAIKTSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIY
NMQPNDTINDAYQASDAQLYLNKQQKQHRSS
>A0A3Y8NX84|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1C6Z0N5|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNPLQSLDVLYINACVTYASLSVSYFVLSKHNALNSNSSLSRRILFGVIAGLISLYLTRS
KMYFTQEVYYSFEIVPMLLVTFFGGGIAGITAWLVNFATTGGFVLDNLLLAVMLVPVLIA
RVWERNTFRTYLKTIILITLYRIVIVLPFLHTKNHMLDILIYQAVSFLCLLVCYQTLSIK
RRSVDAFFKVRAASLLDPMTKVHNRQALEQQMQALSKSRSPCCLVMIDIDNFKSVNDTYG
HLAGDQVLIEVAELIRLITRSSDFVARFGGEEFAIIIHYDDLNRAYHICERIRLAISNRK
FFLSHGPKIHVTASFGISLFDGKTATLEEVLNRADNALYTAKHSGKNRVVIE
>A0A447N7X4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MCIDVAMNITFMNPIAEKMSGWRQEDALGTPLLTVLRITSGDKGPLLEDIYRADRSRSDM
EQEIVLHCHNGGSYDIHYSITPLSTLDGDKIGSVLVIQDVTESRKMLRQLSYSATHDALT
QLANRASFEKQLQQRLQTIQESPQHHALVFIDLDRFKAVNDSAGHAAGDALLRELASLML
SMLRSGDLLARLGGDEFGLLLPDCNSDSARFIATRLINAINEYHFMWEGRLHRIGASAGI
TMINEHNCQLTEVVSQADIACYAAKNSGRGRLTVYEPQHALTSSKGMMPLEEQWHMIKNN
HLLMLARNVAPPRTPEATSFWLVSLRLWTSEGEVLEERAFRAGLADSALHHALDRRVFHE
FFHHAATAVASKGLSVALPLSARGIIQRDPY
>A0A377PEG8|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MLEREKISFLGKGHFLSVASFLLLFCLFAFFIRFGAHRVDVLRSFFPVSTAIVFVLHLFL
TIIILIRFHFKNTHLHLLTIASAYGLSSLFLANSLFIYPGVLISESNINESANALAVDFV
IRSFSMAVLFLLSVLFYIKGRCNYVNKSNVITSCAAVILIAIGFAVVIINHNNILQLPII
ETDELNYRRLWSSHIGSALIIIWVITTFTVVFFTKLVNGFWFSLSLSCLAFLGSILLMWR
SEYVTSLAWYGSHLFEVLATLFVVLAFIYDIYKLYQKGLEDYLESYENSIRDSLTHLYDR
RYFDNKLASRIKRASKESPISLFFIDIDHFKSINDGYGHPVGDKVIRRVADTMVASVRKT
DVVARYGGEEFAIILKGLNSKLASKIAENIRNRVSKEVHVHAGPEKVTVSVGVYTITDHH
LSVDESISRADSAMYQAKKSGRDRVVVYSHPASEFEHTTA
>A0A6G3FC48|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSLL
LSGVWWLLLVGWVFVWPHLAWQLAFRSTCPHSGEIVNLKIDAIIAGVWVGLIGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRAGDYIGRFGGDEFAVIMSGTPAEN
AIAAMARVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A8E7QPG9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Corvallis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALPIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A830DM80|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MVSDNQGVCVQHDTFVVKQSFLQWLHKRSNPSLIVNLCFIVVLIFSTLLTWREVVVLEDA
YISSQRNHLETVASALDRQLQFSVDKMLFFRHSMHDALETPLAFGALHDAVKRFAHLRTS
PTWQIAVDKRRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNE
ERVIYVSRAGFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSF
VGKKPLITASVPVYYHHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLAT
SESPAVDVNHFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGV
RGDFGSISIVLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGS
LFDQAKILAKQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKD
IAGRVGGEEFCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEK
GNYHFENLQSTADARLYEAKQRGRNRVIWQDHLKK
>A0A822WYD3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MALHSKKLSFTRPIMVSFAGILFSFALIAIPVILSQRKDFLEDYHKINGNFTHNLAVNYT
ESILRENDYILGRAAMYFARNDRVNQTINIDPTHGLQMLMHLQNLMPTVSSISLADTEGR
HLRAPEVLPTEKSKSFDARTRPWFVGQAEASNFPHYTRPYLDYFTQHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLFDPKSKTWYYYYSFTNPDWFVIYRVSDATLNVITRHETTVVGWGFALAAII
IILFGLYLRHASRSVLMNIINAIKTGDVNQAPRLEAMLSHTIRTNKERELAYVRQATHDA
LTGCKNRRAFDNDVDELLTAHQPFVLALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFGVIFPAELMNSAHALLEAWRTAVEKRTWREENLRVTFSAGMGEW
HFEPLEQFIGSVDEALYTAKQQGKNRIVSTACR
>A0A8B5ZY88|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
VTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRHAGKMWPGIA
LACSFGNIFASWMLFSWESLNITYTAINIIEATVGALLLRKLLPWYNPLQNLNDWVRLAL
GSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPHYLLRHRNPK
LLLETLVTLVVTLVLCWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFLFTIMMVSLM
MARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITESEERFRNAME
YSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDLEQLGQLING
EINSYSLEKRYYTRSGAVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQTEWVNKRLME
RITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMVPEDRPHAEQ
VLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDMTEVKQLNEA
LFQEKERLHITLDSIGEAVLCTDFDMNITFMNPVAEKMSGWSQSEALGQPVLKVLHITFG
ENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGNTIGSVLVIQDVT
ESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQHHALVFIDLDRFKAVND
TAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYIAGRLIDAIN
NYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVVTVYEPQQER
IHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQGEVLEEHAF
RAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLVDELLDLITK
GPLPARLLHLAIAADVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFSQLSANTADY
LLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSGIGVDFIYGD
TIGEAQPLDLLLNTSYFAIN
>A0A0U5IBB6|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MGTLRSRRLGLRLTVGFLIVALLPLAGLAWFYLHTFERALTATVLQNITSIADKKADQID
SYINERLADARSFASQALVREAVSTLVATRTLSAETRTELATLGERADYHDVLLIDASGD
VVFSLRGEADLGTNLLHGPFRDSELAAGFRQAMTFMHIDMTRFEPYAPSAGEVAAFVVAP
ILDAQRPIGALALQVNLATLMPVVSDRTGLGASGETVLAVQEGQAVRYTVPLERTPGAPF
TNLVPLVRTAEPMRMALAGNQGRGIVSDYADIPVAAGWRYLPALGWGMVVKMDTAEVLAP
LHAMQQATVWAFAVFLLASAGAALVLGRRLVRDERIIAAQQARYRAMLGSMNDGVALFRP
LADGSEFTLLDINAAGERITGVKRREVLGRPSRIAFPGLDAAGIYAAFGRVHRRGGSETI
GLTAYVKDRQSLWLETDVIRLHGGEILTVFKDITARKTADERIEHLAHHDSLTGLVNRHN
LQILLAQALHAAHREGRLLAVLFIDLDRFKVINDTLGHHIGDLLLVEVARRLCRDVRESD
IVARQGGDEFVVMLTALECAQDAAVVAAKILHTLGEPFDIESDRLHTSPSIGISIYPDDG
MDADTLMKNADTAMYHAKEQGRNNVQYFTETLNVAAGERLTMERELRVAIEEGQLALHYQ
PQFEAAADPLGCPDAMEALVRWRHPLRGLITAGQFIPIAEESGLIHTIGDWVLNEACRRL
AEWKAAGIGPRRIAVNLSAHQLRNPALLQKVVAVLRRYALNDDELELEITESVAMRDPAR
AVKTLQALRDLGVTLAIDDFGTGHSSLAYLKRLPIQTLKLDREFVRDIETDENDAAISAA
TLALAHELGLRVVAEGIETEGQSRFLQQHGCDLLQGHLYGEPASAEVWTTLWTEGRTAEL
SRTRNHSA
>A0A7B2BC47|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8E6NGU6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000542|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAMLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6N8R7I7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
WLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLM
SHMPWLPFLLILLPANIMTMVMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWL
QTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNG
DVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEW
ELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEF
RITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIG
EAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSR
SAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHD
ALTHLANRASFEKQLRMLLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAS
LMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGAS
AGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAAMSLDEQWRM
IKENQLMMMAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQKFRRSFSDPALSHALDRR
VFHEFFQLAAKAVASKGISIALPLSVAGLSSATLVNDLLEQLENSPLPPRLLHLIIPADA
ILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEML
ITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X5PX85|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSL
PLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLL
QIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVL
IIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENET
LRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGR
NRVELWKASL
>A0A1C3RBX9|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MNPHNVLLVDKSEPSDIVTCLQEMGISLFQSASQMPSSGDIQNIDLIIYDCDGAKGSLEL
DKTSQGSPAVLVVGSVETKEKAFEYLDKVADEVLIRPFDPLEAQLRISRLLKNRRKQSTA
KLPEQTEHIRYEKLLDLSMDIILTVSNGIITFANKTAETLLHVKEDGLEGTHITSIAQKD
WVEAIEEVLPELAETGDRLPIQLLGSDGRAIHVLIGAVAIEEEGPNTYMVEAVDRSEHKQ
ALENLLQRERRYRSLVELSSNMVFVISDGVITFTNPTCDQLLNSANDPDGLVGRPMASIV
DIDYVPLIDGLDELAELNERLPLKFRSLDGTLMDVIIGVAHMDAEQGESLLVEAVDISQQ
KKSAEALLEREERLSGIVDNAPDAIITMDEAGNIESFNNSAETIFGFDRSEAVEKNIFDF
IQLLDLQKDANPKKKIKECSALEATGIKNDGNQIDIDLSIKSMIFGEHQRYIAIIRDVTT
QKRDHEELAFLATHDPLTKLPNSHFILKTIERFTESPDSDTKCSVLFITLERLNRVNDLF
GHQMVDHVLSAVANRLNETIGTYNIIGRWGGGKFVAITMGLSHDEIVNQICNEVEEALST
PFNIDDNDIVIGCTIGISCYPEDCDSPAALVKNAGMAAFAARQNENTPYLFYSKEMEAEA
EERDMLERELRLALEHDQLEVYYQPKIDLSTGFIKGMEALVRWIHPDLGFISPVKFIPIA
EETGQIVTIGEWILRRACQDTKDWIDQGATDLKVAVNLSGRQFDDESLLSNVKATLDETG
LKPTNLELEVTESSLMRDVDQGMRTLKELRDLGITTAIDDFGTGYSSLSYLRRIPLDTLK
IDQSFVRNLHVDPDDAAIARTIMDMAENLGLKVVAEGIEIAEHEEFLKTIHCHIGQGYYY
SKPVPSHEFDGLLQKFSPLKGVVYERRVGVDRRRYQDRRV
>A0A827LR44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSNDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A418TWX5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYDRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376MAS3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALLFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKKSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQKNELNPKE
IYQLADNALSEAKETARNKVVVKEAEILINRKDDE
>A0A826WZL4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPKKIMNDENFLKKAVAPGEEPPSSPQNEHQRSGLRFARRVRLPRVVGFGGMFFPIASAL
VEQPIAGWWWLILVGWSFVWPHLAWQMSSRAMDPLNREIYNLKTDAITAGMWVGIMGVNA
LPSTTMLMIMCLNLMGAGGIRLFVAGLVLMVVACLVTLQLTGIRVAFTSSPLEWWLSLPV
IVFYPLIFAWVSYQTATKLAEHKRRLQVMSARDGMTGVYNRRHWETLLCIEFDHCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAILALTRQLQMTLRSSDVIGRFGGDEFAVIMCGT
PAENAIAAMSRVHERLSHLRLSCAPQVILRISVGVAPLTPQISHYREWLKSADMALYKAK
SAGRNRTEVAA
>A0A2X3K5N3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRARNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFIS
HWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGRR
>A0A657FZ20|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Denver|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A797AQF0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A378AAY4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MLTGSILLASFIAPAADPLPTRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFA
QDFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPFDRPS
>A0A827UH30|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A646IXK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIYSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRELNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANLASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8B4NTB8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MINDAVFEKSAITLAYSYIPEVMFIVAYKKDKYIYMCLLFVFTSAISAGLIYFHYIKLMQ
KIINKGKSEKESILSNNHYNLHGKNLFFNVEEIDAIREIYDSGTYDALTRASGCRVFDKN
IRMLSKDFGYLCLFDVDKFKTINDKFGHLFGDEVLIRLVNLIKDELPLSKGEVYRFGGDE
FAIIYHDKDINQISRILHRIVHFSIGGLNCSCSIGVANTDECMNNIERLKLLADERLYKS
KQNGRAQVTWC
>A0A7H9S5S2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKDITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8G2GVR8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKWLAEFGGLRHKAYRLGGDEFTMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A828GNR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPFTPQNEHQRSGLRFARRVRFPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A377EPL5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIPIADEALYIAKRRGRNRVELWKASL
>A0A2X3K4S7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMC
LNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYPLLFGWV
SYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDH
FKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLR
VREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>A0A376LQ25|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQDLTFSQLRTSPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELT
EAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDA
NLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRH
VQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQM
QHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEF
VLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDAL
YRAKNDGRNRVLAA
>A0A2X3K9H3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQNRRC
>A0A377ZMC6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTITAMIYLSGAKWPAATAASGRT
>A0A1E5MCP3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTLREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRILSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLYQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A2X7Q1U1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEYDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376VLA5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPR
FTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X5QJ97|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKSSI
R
>A0A7A6PLN4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVGQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377K5B1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTRLVGLLVMQTRH
>A0A6D0DDY5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHSSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHLTGN
IFDPRELALLAQAMEHDTRGGIRMSSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2X3K6C5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAKIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKL
ADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYH
ITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVF
RWGGEEFVLLLPKNPTGYRAFAG
>A0A377DS83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSL
ADRRLYLAKQAGRNRVFASDNA
>A0A2X3LXS8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWK
>A0A2X7FSI5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDPITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A376JEI5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGTPVEIVEMGFRVLKKSSI
R
>A0A485DXS3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLITLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A376YBZ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFPKK
>A0A4Y8FYN9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A1V5QRB0|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MAAWFSSRERQSSMEGHLQRYSKRIFSWVFALGGVGLLPFALLHWVRGNLLMAIPVALLV
VVFIGFATWTFSGRRLDSTAVLLLTLFCNFVGLFALINVRELGFYWIYPLLLAVAFLVPW
RWSAPINAANILFTIVFAADSAPEAHLYRLIITLFLTYTFTVLFSYNIERQQQALKDLAV
HDPLTGIYNRRYFEQKQEEAYRHWKRTGRKSALVMIDIDHFKEINDCYGHAVGDQVLVAL
SEFIGKQLRPLDLFFRLGGEEFALLLYETTADQAALLSERLRRHFETGSLDGLLPAFTVS
CGVAELPEHGSSAVWLEQSDEALYAAKRAGRNRVVVAPSSEERGDTA
>A0A6C9JFV6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHTAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376TH60|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHK
PLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGL
LNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESC
ARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEG
NESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377CWL7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASEN
ETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRR
GRNRVELWKASL
>A0A377K4Y2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTSML
LLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTHQHPFSVI
QVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILPGANLTQA
AEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQA
GRNRVFASDNA
>A0A509EBB2|diguanylate cyclase|EC 2.7.7.65|Methylobacterium symbioticum|TrEMBL
MDVLPDLQTLRLCSLLASTAFAMVFLAFWQARRAELFWLHWAGSSLLYAGLMVGFSRVEH
AAAVALLYALLAGTNILIISGVRAFDGRPAFRAWMLMPILATGLGFGLPAWLVPEPALAG
TVSRIGGTALLASSSALAGATLAFEPQAQPSRGRRIAGFAILGYQPSYALAIVAEVSGWS
EPNMAALLPMLSDQVLLGIMSLGLLAMPGERAQGALRDAALRDALTGAWNRAGLAARARL
PAPDAAVILIDVDHFKAINDRHGHAAGDAVLVALVARIGALLPGPADTVARLGGDEFAVV
LHGTTRPAAHRLAGEIRLAARRAAETPAWTVSLGVAMAEGADLAGALARADAALYAAKAA
GRDRAA
>A0A7U9B2H7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA143|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNARNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1S7LHS7|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MLCQTMVEGISIWYADGKLCYANDAALKLFGLVEAPQTSLHYTEIMTRMFDHNRASMTNE
TFPLSRTLRGDKTESNTLIGTTVKHLPIWFHLNAYPITNSDQSLAPLILCVAHEVSDVVE
RSLNLSQSAYYDNLTGLPNRSLLHDRIKTGIAHSKRNGQILAVCMMDLDGFKPINDTYGH
EAGDEVLKVTASRLLENMRGDDTAVRLGGDEFVLLINDLKSEDECILALNRILSSVSQPT
PFGDAVCQVTGSMGVTLYPNDSSEPDTLLRHSDQAMYKAKERGKNDFEMFDPTLASRHRA
NKSTLSRIAKALDKKQFKLFYQPQVNCQTGEVVGVEALIRWDHPVLGIRPPGEFLPLVEK
DDTIIALGNWVIGEALAQWQRWQAEGLDLTISVNISARQLLHKGFGETLQRVHASLPNGH
SNPLELEILETAALEDLNSVARLINNSRQMDYKYALDDFGTGYSSLAHLKHLSVNTLKID
QSYVRDMLDDPGDMAIVQGILGISEAFNATVVAEGVENIDQVMMLIGMGCQVIQGYAIAK
PMSHEKFAAWLANYNSNPVWKAARDTYPSRGQFDLLVIEVAHRHWFEQIQRSLQHNPTNT
AQMPPLESYDQCKLTSWYHGEGSKHHGHKALIHDMDANHRKVHDKYKRLCEQIDQKDEIS
AMLTIKELQELNNTLITAIHQLRMHDH
>A0A1S7LDG0|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MLCALLIADRAYALNEIDLTPAEIEWLQNHPEIKMAVDIDWAPFEYVDPQSRYKGMAAEY
IRLIEKRLDIAFQIDKKRKWPEMVKAVQNRDLDIFSCVVRTPQREAYALFTKPYLTFPMV
IVTLEGQGFVDGIQDLIQHKHSVSVVKSYASHELLVQNFPQLNLHPTGNVKEGLEQVSSG
QVYGFIGNLAVVSQVMRESGLTNLKISGQTPFRFELSMAVRNDWPELVPILQKAIDSITQ
EEQDEIFNKWIRVDYSQRVDYTIIFYTVTIGLLIFGFILYWNRKLKAEIMRRHVTELNLK
RSKESLDKAQAIAHIGNWDWDIEHGSLAWSDEIYRIFGLSPQAFAATYEAFLESIHPDDR
HLVKDAVAAALEDPNAEYEVEHRVVHPNGEERIVREIGHVLRNQHGQPIYMRGTVQDVTD
FRSTEEKLILSKLVIENASEAILITDHQGQIIDVNPAYEQVTGYSADEVIGKNPNITQSG
RHDASFYKTMWQTIRQTGKWEGEIWDRRKNGEVFPKWLTINTINNRRGKISHYMGIFTDI
SRQKSTEQTLEKLAFYDPLTSLPNRALFRDRLNHEMSLTSRTGGALSIFFIDLDRFKYVN
DTFGHDVGDELLIEVSNRTVHCLRKSDTVCRLGGDEFTVILPDPGTAESVAQVARTIIES
LQKPFQLKGHEVFIGASIGIAMFPTDGDNFEVLTKNADLAMYQAKEAGRGTSRFYTPEMN
KKSELRLMLEADLRKALELKQFTLFYQPKIEVGSNSVAGMEALIRWIHPKKGMVSPVDFI
PLAEETGLIIPLGAWILETACAQAKAWLDATGRELRVAVNLSAKQFQDPDLLENIQATLA
RTGLPVRLLELEITESVVMDDVESAIETIDAFKALGLYISIDDFGTGYSSLSYLKRFPLH
SLKIDQSFVRDLTVDSDDAAIVESIISMAKAMGLAVIAEGVETDEQLGFLEQKKCGHIQG
FFFSKPLPAEEFAAYVESCDPNCSTE
>A0A7V8QA13|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MSASLPTFLTVDVRRSGLRFSQRVYIPRIVGTIFCSLFISSVLMTKSVPTLLWVLLFLNT
FIWPHIAYLFSLRSSDPMGCEKRNLLLDVAFGGIWIGFMGVNLLPSALIVAMVGMNCTAG
GGIKLFVQGIALLCVSCALTLVLFAVPVSLDTTPIQIYACLPMLLIYPISLGYVTYTTAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDICQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKAADMALYRAKNKGRRRTEIA
>A0A5B8RF38|diguanylate cyclase|EC 2.7.7.65|uncultured organism|TrEMBL
MPSAPWRCCSVAAPDGRARRAGPARTAGACARAEAKIAELRRRLAEERNRGATDALTGIY
NRKAFQERFAVELARRQRYGRRLSLIILDIDHFKGVNDAYGHVTGDRILTAVASRLQAEV
RAIDLLARYGGEEFVVLLPETDLQQARHTAGKLLARIRDEHFQTGEHKIGITISAGVTEV
RSDDTAARALERSDAGLYAAKNGGRNRIGVSGD
>F5RSW1|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei ATCC 49162|TrEMBL
MFCPDLRIGAFFCLSPSPLPEEYIKFFSFMFYYGRSLYFQHNMQIQRSSAWELTCLMSDI
ILARVSETLSTEQSLDSLVRQLLEMLEIVTDMESTYLTKIDINARLQHILYARNSKQMQI
PEGFSVPWDETLCKRAIDSDTVFSNEVPERWPECEAAKALGITTYMSVPVHLADGSLYGT
LCAASTAQKQFSERGEQVIRLFAGLIGQYIQKESLVLQLREANAALIAHSYTDALTGLPN
RRAIFENLTTLFSLARHLNRKVMMAFIDLDDFKRINDQYGHEAGDRFLVQVGRRLTHEQT
QDEIIGRLGGDEFLVASLSHGDDGDASTEVNAIKTRLNSRIAGEYGLGNATILYPGASLG
VVIVDPHSTDEDSALRTADLAMYQDKKGKSKTGFVALD
>A0A174ZU01|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MSINKKEFNLEQVVKLCVVVNISLFLFVAFMLTLFVYFNITPMIYYSVIALIGYVLYFML
LKRQKVSAYMWCVYATIIIYMAIATICLGYKCGFHLYSMSLIPIIFYSQYISTKTDTKDP
NPLAVSIAIVAVSIISSAIAIINGPLYEINKTIISVMLACNAISVSAFLIYYTKVIVDLV
IESEKKLNSIANIDLLTDLYSRRYMINYLEEYDADDEGWLAMADVDDFKKINDTYGHNCG
DYVLNFIAQKMKNICSNCVISRWGGEEFLIHNGTHDSTHEVLEKLRREIENSECIYKQQK
INISLTIGVAQRNADGDIEEWIKHADDRLYYGKNNGKNMVVD
>A0A5M8BE93|diguanylate cyclase|EC 2.7.7.65|Cupriavidus cauae|TrEMBL
MTSAQEAPPLPALPRWQRVSLASALFFLLAIAGIALTRYPGNAAIVWLATAFGAGVALHQ
RPRERAWMLAGMLVSGVAANAMFGDPWWLALVLGASNVAEILFVAWLAPSISGGIGRASA
VPLARFALMLGATCTLAPVIGATIGAAAISAAYGRPIGDIWSTWWSADAIGMLMLVPLSV
TYSRERLRETFSRARLPRVAGLLLLTASVGGLSVLQTHDPFGVLSLPLVVAALFTNPFTT
ALLTLLSMLVTVMLGLAAAQAGLVDAPAFLTHAMKLSTSLILVFPVCIAYLSEQNRRDRS
ELRGSERRFRQAMQHSAIGMALVSLDGRWQQVNRAMCELFGYSAAELSRIAFQDITHPDD
LAADLAQLERLVAGQTDSYRMEKRYRRKDGNFIWTLLAVSLVRDEATGAPLHFIAQVEDI
HEHKLAQQRLEALSRRTELAVEAGRVGIWEWDIAAGTLSWDRRMHALHGTEAVGGAPDLD
GWIAMVHADDVMRARHEMRQAVKGTQPFDTQYRIVRPDGEVRHIRAMAVVSRADDGTALS
MVGTNWDITEHHRLTEALFEEKERLHITLRSIGDAVICTDAALRITFINPIAEQLTGWTM
AEADGRPLATVFHVVDETTGQPIACPVAKCLQTLRPVYLEDGAVLISRHGERHDVQDSAA
PVLTPRGDVIGAVLVFQDITTARALQRKLAHSAMHDALTGLPNRIWFEQRLREACESARE
FEQQHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRSQVRPGDLLARLGGDEFALLL
RNCSVDQGERVCLKVIDAIRARRFPWEGRVYDVGASVGITAIDREAPPLGELMSRADVAC
YAAKAAGRNRVSVYRRDESDARRHHRELQVAAGIHSALEANRFRLFAQEIRALAPEAGGT
PPASTTASSSASASASMPASASASASASASVSPAASSPPTHIEILVRMVDEHGSLVMPGA
FIPAAERYDLMGHVDRWVIQHVLRDFGARLLAVPGLSVSINLSANSLGEPFLLPFLHAEL
SNSVLPASRIRLEITETALINNMAAANRLVADMRKAGCTMALDDFGAGLSSFAYLKQFPV
DYLKIDGSFIRHLAASAVDREIVSSINDIGHRLGIRTVAESVEDEATLDVLREIGVDYAQ
GYAIGRPMPLEDYLARCAGSVPGETAQRQSR
>A0A1R3U0L7|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MEGSVVRVTLSLIGPGILTVFAAAFSAAWLIDRKRHYLLLLSGSCLLFALGVVAQVMYWP
RDTGLNAMVSGAFYTCAVVSAAQGILLRSSQSISGRFALSVTLSIMALLWYFFYVDRSLI
ARIYIQNFGYGAILIFTAGKLLRSRTARPVDNVLFWTLLLFGAHFFPRTMFTIGFSEPIS
PSAFADTVFWQALQLSLAVLGAALALAILSAAMVDIIGDLRNERDRDHLTKLLNRRGFEA
AISAIPPRTTSHALILCDVDWFKSVNDEYGHDTGDAVLKRIASVLQKTARKHDIVGRLGG
EEFAVYLTDATVVEAHDCAERFRKAIRSADFSDMLGSRRITVSFGVAVGSGEWVRMYKTA
DARLYEAKKKGRDQTVSVDHASSHILGAEQ
>A0A5C1BWZ2|diguanylate cyclase|EC 2.7.7.65|Enterobacter chengduensis|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPIAGMLVTHF
LAGGWWLLLVGWAFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGVMGMSALPTA
ALLMMVGMNMMGSGGCRLFIPGIALTLLSALVVLPLFGRLAVFNPDLLEWGLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRSHCTATI
LLIDIDHFKNINDTWGHDVGDEAIVAITRQLQLSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHERLENLSLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
SRTEVAA
>A0A175A084|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MKTKKYESIMNKAMKAAMNYENPDDQINEFIRFFGEHIGSERIYIFEDNIRKKVTNNTYE
WCADGIEPQIEFLQNVDMSIIDWWYTSFNDGRNISTKDIEEIKDEYPAAYELLKVQNVKS
LAVSPFRYKDEIYGFFGVDNPPESEMDEISRFLDMIGTFLVLLLKQRNVFKKSKREAMFS
AYSALAGIYLSMHIINLKTGEFHEIKSTDFIRDNMIKGEHTFAEQINSVMKILPSRKYVE
SVLEFVDISTLPERMKNKTTIVHEFLGNYSGWCRERFIRVDEDSNGELWHVVYAVEVIDA
EKRKENRLLYLSETDLMTGIRNRGSGEEAITDLIKEGTKGLMCLLDCDKFKNVNDTYGHV
VGDAVIIAVARSLQSVCREHDICMRLGGDEFAMFIPGITETKDAESFTMRVFAKLKDIRI
PEMGDEKIYVSMGEAFYKGEKDIDFDELYRRADSAMYKSKNNTGYCATLECVTKTF
>A0A1F2PLZ2|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKFRNLSIKYSMMIVLVAIITPLYFLFAMINYNSIRNGILNNTQLAINQTRINIIDTIIS
TEKSYELVSTYYDEMMAESLQLFNAEYETQKGNVSAIDLDAIKARYHNNLDLYIIDENGV
IIRTTFPSALGIDFKTVPDFFKTLTELRQRHDPEISHVTTDLVTGELRKWGYIPTADHRY
VLEVGISPGSLSQFITQLNYTDMEKTVQDNNPFIADITVYDKNHIMLGSGQTETDPARIA
MIDTVISNGTDQIITGDLGLLDQEYIYVNTFPGGMNDSQKVIAIRYQYDDIIRQINGTRM
ATLLVFLTYTVFSLLLIYFLVTRSITEPLIRLTNRIKGVSGTNLDFFMPVSGSNELGQLT
QSFNELSAKLQSTLVTKTYLENVIDSVGDILIIMDSDLKILRINQYTRLFLSKHCGQIVG
SPIDTIFDGSSSLRDLQAKLILNPRLENIEGTMIKDNHQKTTVIASISAYRSEDGQILGY
ILNAKDISKTKQILKKLEESNLFLKKQESILLTQSTIDALTGACNRGCIFNILEDIHANT
PLLYSTFSVIMIDLDHFKSVNDRFGHQAGDTVLVETVQIIMDNLRKSDFLGRYGGEEFLI
VMPDTTLNEGYQIAQRIRIKIKDTRFYHDRIELTISGGIAEWDHNSVSELIETADRLLYQ
AKKQGRNTILRTEKS
>A0A1G5SFT9|diguanylate cyclase|EC 2.7.7.65|Nitrosomonas mobilis|TrEMBL
MNNKNLSLTQAELQKRNAALALEIQELKRDALKYRGLIESAHAIVWSADPETFQLTYVSK
EAETLLGYRLASWTSETDFWLQHIHPDDKEWAVSYCLAETRAHREHKFEYRMIAADGRTV
WLYDVVEPIIENGELKELVGVMMDITERKEAEAALQNRTGELTLQNSILQLINQKMALNQ
VLDSLTRQIEALHPEMLCSILLLDAHNKLRHGAAPSLPKAYNRAIDGLAIGIAAGSCGTA
AFLGERVIVADVKTHPYWTAYREIARKACVQSCWSQPIKNSTGQVLGSFAIYHRQPTLPT
DTEIFLIERYADLALLAIEHDSAEATIRNLAYYDPLTQLPNRRLLIEQLQHGLSISQRDG
KPLALLMLDLDYFKAVNDSLGHLAGDNLLQQVAARIKARLRTVDMVARLGGDEFIVLLEN
LAHEEDAARVAESLITDLEKPFSLDQRNDIRISVSIGISLYPQHANTSEQLLVQADAALY
QAKDAGRGNFAYYSEAMTLAARERIELEARLRKVIEQQELRVFYQAQVAAASGRIVGAEA
LVRWQYPDGQLIAPGHFIPAAESSGQIVALGEWVLAETCRQGRAWQDAGLPPLTLAVNVS
PHQFRSSDMNALVARILKKTGFPAKYLELELTESGLMDNQTKVMGILNDLRAQGVRLAID
DFGTGYSSLAYLKRFPLDVLKIDKSFIDDIPHSQYDMEITATIIAMGRTLGFKVLAEGVE
TTAQLTFLKTKGCDYYQGYLKYKPMPSDIFAELLRQTARPPR
>A0A1F2PGJ9|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKFKFFMLISMVILGIVYGFVYHYLAMPLLGDNEFVHCLGSGTIFGLIAYFVAVNITHKY
YKLEKVYNTLKRDIDIDQLTGLYNRRAFDHYIKKISKDKVYSLIFIDVDNFRKFNNEFGH
DSGDAVLQKVSATIKNAIRQNDRAYRYGGEEIVVVLNKCSKHNAIKIGEKIRCNISSIDN
SPQPSITVSLGVASYPDDGRDISTIIKLSDEALLEAKKSGKNRLVYKMI
>A0A1F2PFS7|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKQRNKVGLLISLIILIGIVAIVFFSFTTYSKIIKDDVLNISKLTSTNIYSEINNELTKP
IFVSLTMANDSFVKQWLAQEDPQRNPEIIDYLEGIRSKYNYHSVFLISAQSLNYFHYNGL
FKTISPQDDHDQWYYDFINQDKLYVLDVDQDQVDNQRLTIFINCKILDEQGNLMGVAGVG
IEMTYVQELLENFERDYDLEAFLVDETGLIQAHTNPNLIENQNINDLDIYAAIGPELYNK
TDAINVFNDDDLYNQQYIISHYIEELDWTLIVRKDTSELAQSFNQQLYYDLFVVILVLTS
VLIIVQRIIKKNDQQMKKLALLDNLGILSNRKDFDQHLTATLAQSDETRGAWSVFLMDLD
HFKDVNDTYGHLQGDKILIHVMTLCKAALSDHLITRWGGDEFSGIIYLAGVLAAEKMEAL
RLEIVNDPMLSEFNITVSIGITQAIDIDTEDTILRRADKALYESKSSGKNQVTLL
>A0A1F2PI04|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNIILSTILVVSSMVLIVLGIVGFRHRGISGVKAITLLMFAMAIHSFAYGMELMSSDWET
MYQWIRVEYLGVSFYPILILWFAREYAGERRFANNYVMGIVLAICTATLFLVETNAMHGL
YYAQMGVDRSIGFPIVMTQKGQWYMVQVGALYFAMIYALVVLIGQILNTRGVTRRRAFLV
FTGMLVPMIASTCYLLGWGIGEIDLIPFSFIFLSVLVASGIYRYDILFLSEVTHEMIFNT
IGEGVIVVDSEGYILKMNRAMQSLFGILGQLKIGEPINRYMVLAHILESNDSQTIAMGDK
HYQIRLNAIGKHHGTIVVFTDVTEITEAKKQVEILAITDHLTQLFNRHHFVQRFNQLEKV
GVVMLLDIDHFKLVNDQYGHQAGDTVLCELADCLSKHFYDGVICRYGGEEFAVLIEGESL
ENARNRSETFRTAFQSRQTAFPCTVSIGLCWYNKEDYSKTMNLVDKLLYQAKNAGRNAVV
WEEALET
>A0A1C5LQK9|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MYTVEEIKNKVKTGTWTKEDVARCVEELKQISDFTVYTEEIYYISYGIFAYNFREYAYPL
IEICREAGVHMERSKEKSRLYLALVRLYFCLGFPPKIVEYGLKYANSGFTLGSPLKSVYN
TIVAAFSDCGLFFEADFYLEKMMDISRLDPCDSSVDFWNSDTLNELVYYDSKVYVKLGMG
DVAGAEQAAVDMQAILTEREIPEDGRAFFLLQKEFTDLYLRLYQQKDKAVIAEEFNSYMK
KMEAGEGARDTLSFCVCYFGEFLQVMAEEERWDDIIRIGNYIKNARNFSGRFCPVYKLMR
TAAYGSDREELRRQIPEFERMYLESLEQEKENYDQMVRLLTREELRIERLKVSMDKDALT
GCLNRAAFDRNSRRFMKNHKKGSLVFIDLDYLKLINDCYGHENGDRYLVCFAENMKCAMD
RQDLLYRYAGDEFLILSALEPEQIQGRLNEILEKSPIHFDINGESRNISFSYGVVAFEEK
KGKIEDLVKEADQRMYQCKSRNHERISKRGAAE
>A0A0E4A6U9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MSDTPKVVHRWLAVPDQFDRFTRFLRDNGILMPTRIGIGILVFLLGVTILLKRLGTHSVQ
TIGFPLDVVIAVLVMIGGTALPFTATTRERSYLFVIAGDLAVAVIVLAEANPDQRLLGCL
VFGLVGSYIAFFHNLRAQLWHLLFSGAVIVIASIGVFTDVPSGLSDVLGRIAFAIPVITV
IPVVTQIALALLSNDAQSSELDPLTDLLNRRGLSRRTSELLQAKSSLDQSLLVVVIDIDN
FKHFNDTYGHDVGDRVILRTAYRLHDWARSDAAIARIGGDEFVVVQIMPLPYVGDLLARI
APIMNSPTGEPLSTTSIGIAIHNGGWPDVQAAESGVHDLHRLADSAMYESKRMGGNHVHS
IVLTDQQPQQSGGRSVV
>A0A8G0X8G7|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MRQRRLQLMQSLFDEYIEMYSSRNDKLTTRFSDNFSGYAGSSDVLITNKEEWIRITRQDF
AQVPERIHIEMLDLSLQDLAEDILVVTAFFHIHLPIPESILCQETARLVLIFHQENKDWK
IAHSGISIPYGLANNGEIYPMTSLEERNRELESMIEARTRELAEANSRLEKLSNTDGLTN
IGNRRLFDHILQMEWSRGQRSSAPLALIMLDIDHFKLFNDHYGHLAGDDCLKLLAKGLSQ
SGRRAGELVARYGGEEFVILLPNTDQQTALDTAQYIHQLIQSLAIPHVKTDLGTVTVSLG
VTCIEPSEQHSALELVRQADAALYLAKSAGRNCIRYMSPSVNKLET
>A0A1C6JZ71|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MVVDGLPSGYRWLNIVSNYLGFGLSPAVSVCLVYVLDRKTALRRKIRIAVCCEIAYLMFL
LVSVPYGMVFSVSVDNMYSRGPHFYIYVIMYFGAILYLSISTIITAREFQNRSRMLIYPL
ILFVMVETVIQVALPELHVTWLCVTLLSVLYFIYCNEMWNQLDALTGLLNQNSYLNQTQK
IKYNSGVLVVFDVDDFKQVNDCHGHVKGDLCLAGIAECIKKAYADSGYCYRIGGDEFCVL
LKNRAKEEECRQEFLRRWVEKRRKFTFLPTVSYGSAPFSGEDIAVVKDRADQDMYQYKKG
RKKHGSSGVLSEQQKYQN
>A0A727B9U3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ank|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A174EB47|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MKLAKSGKYCLCAFIIIFICIYMAVPVKAEARRVVRVGFPEQEGFTEKGRDGHYSGYTYD
YLQELSQYTQWEYEFVEMAGDINESLTALLDMLANGEIDMLGGMTYSDALAEIYDYPGMS
YGEVGLVLAVEDDNSELTPVNFTGREMLKIAVTGNGGRQQDAMIKYLELLGQNYELVHCA
SSEEKLKLLRENKADVMMDTEAGISKECRIIARFSFSPFYLAVTRGNTELLKELNAGMAE
LKETDPLLIGRLHDEYFNRAASRLIYEENEKSYLAQNKTLRAVVLNGKLPIQNVAAKTGE
AEGIAVDFLNYISEETGLTIEYIGITDPEEYRSVILNDQADIILALPGSPQLMEQFGIIH
TLPYMNISQILVIHKGLEPGELKGKTAATYDAFGNRDENAGEEKLYYSPEAAMEAVDQGE
ADYCYIDNYSFQYCINKRVYKNISSIVLAESGSQSISMGVVKDSDLVLHGILNKVIAYMP
EATKESIFYESSISQERTSFLEYVRANPLPFAAAVLLLLTAAGAASLHNIRNRYEMSRKM
ALEYQRYRQLSEVVGECIYEYDFRGDVLKFLGDGVYKLGVPETISAFSVYGKQQLAVREI
PPEESLYQWIMEKKDGTKDVQIIFAREPERWYRVTSKVVKDDSGYPVYSIGRVWDIQQEK
IEKDRLLQKAQNDGLTGIYNSATIRENITKALNQSSFGGALLIMDIDHFKSINDRYGHSV
GDHVLTQVGMKMKHIFKGEIYGRLGGDEFVVFLPQ
>A0A7L6PH67|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00127|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A1S8SDU7|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MSNFFINILLLISAISLGGHLSKDTPLECSSKIFAKVLLGLGGGILAIGMMMYTINIEST
KTLVDLRVVALMLIYYIGGFLPSLITGVSIVLFRIIYFGINQSSIVAGYQILILLLSYSI
AGKLKLNMVKKWVTIYLLSIFSIISTYYYLLFNFGDVFKILLAYLIMSAIAAILAYYLLK
YVKSSNELYRRYKNEATKDFLTGLNNTRQFDLIFNKSVENVKEKDEKLSCLMIDIDHFKY
VNDTYGHAVGDIVLRDLAVILKNTCRVFDAVSRVGGEEFCILLIDCSKERAMDIGKRICD
EVKKHEFEIGDGRKIGITVSVGVSAYPELTDNIETLLRQADDSLYKAKQTGRDKVCSVDI
CDEI
>A0A1S8RBS8|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKYGIILDRLVNFKLVKKRDELELRNVNNKYLIEHEIVIEENFSNYIVTDTERDARYVL
CILKNGFTYEKTREYLLSKFKTIKNLNFENVTNIINIEIIYSINGIKLDTPQYGYLMEYV
EAKLDTQDYFNKCDFHKKLDTFMEICAAINTLNMQGYIFDDISMKDVILIPDSNNNVKVK
MKDLLANELRKFNLINSLPYQYNLETREDINSNKDNIVQVAELCRQIFTESELETGFKGL
EDIKNIYNRVNTINKSFKLKYFIQNINKKMKKNYRVFISEALNKIKTDLDIIGMTEEIKI
VEKNFQRILENKQRNKFINFNGEDGSGKTRLLEEIKYRFENKYFKDIIYIDDFNNKNASN
EEQYNTILNYILNKVDKNLRDKYEIYIKKFISILFEKNSTNSENNKQKLQLINRMGKFIS
EYTMTKPFIMIIDDLDKKNEVFKLFIKYIIFLRNNLENVMIIFSMNESSVDENFIKFINE
LKQVETYEEYKINYFNQYNTTKMIRSMLNTGTDVNKLAVKIYSETLGNPQYISGVINELY
GNGTLYFDSNNGEWKTNIKVQDILIPKSLERRLEASIFSLNEEEINILKELAIFKTPLSE
KIILEYVIMDSDNIEIYDNLKSKGILTDKISDQGILIGFRNNLLRNILYLKLSEEERIKL
HSKASIFMEKILLDTDYYIEELLLHLEKSNSYEKAYFYTLKYAEAQDLLGDISKAISYYK
KVLTYPSDSSGSEVAIKIAKLYEKKSNHEKSFEHFEKANQIAIQNDEIEIEIYTLLEMII
IKINSITDIDTGIDYSLNCVRRLLDKEHYPKGEVYYYYALSLKYRLEYNNKLTMLNAQKA
IIICEENKIKEDVYGWAVSILINIYIKKGNYKEAKNLCLYANSIFINNNNINGQLYIKLL
DASVCKEEGRDNKEILEQYLEIAREGNKQKVYKREILSLICIADIYSQEKRYLEAEKYLL
RALEREREEGIDSYSFNICNELCLLYIKSGRISLVVKYHNLIMQMQKGLKLLEDRIINTN
YTYALYNLMICNYDLAYDHLKKIYALIFNSNSSKYKIVVCNYFELILYKCKNESDIRNVY
NKLEKKIKLLQDVDTCLEIRISAIRRILTLGYKGLAKELFFDLNGYPKNYNVEGIYVYLE
LNFRNRNQYNFLINKALRVCSFVDNQEIKADIYSAIGEKYNELECNVLALNYYYESIALY
IDTINLLPQNDKLSYANNSRFLETRKLFVKCLNEDLGINMSFKSTQFIKTIEDLEQILKE
LDLMNILDNEDTFKLVQYLYEKCYYNDFRDIFKVFEKFSNNTIDDIKNVMKYMARLILAD
KAMIVTENEQGENDVICTYRISDKNEINRYLSLKVDSDEDTFAICSNDPRFYQLDDKVLK
DGIRSCMYMKIINREKHINSSAGINARLIFITNNALNYINNESKKTIEKFKPFLTFLLEK
YNLTISSTLDKLTGVYNRKYFEEALLFLLDSAKARESEFAVMMFDIDDFKGVNDKYGHQT
GDEVLVKVADEVKKCMSKGDIIGRYGGEEFIILLPNVNCEAAINLGERIRKNIEEARILG
DKRKVTVSIGIAMSSYESLNNEEIIRRADQALYKAKRDGKNRCIVWENECGASGNTNDEL
TGVLSGNAAKDYNFMLMLKEIAGIAKRRCSKEEKIYNLILKIMQTIECDVATIFIVKEKK
IVNTYSKRRNKDNWNLDDRFNFKLVNQVIEEEKGLYLVDWESMDSHNSYGLPDWKSVCIA
PIICNGELLAVIYLSISVNEKEFICNDYNVLNFLIEIGSSIFLG
>A0A554WPQ4|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MPHAAMLDHLEHVARLTHGRDRDVLDATLADVVLATLQARAVVLWGDEGELLDVRAHARA
DALPGPVATAGTPSPQRPRLIERPELVQTLQAGATTVISDARGSRILVPLLTETQRRLVL
DVALAAAADAQARRVTEGMGRIYVNVINLLDACERDTLTELLNRKSFDDTFYKATRAPDE
AVAGVQRRVDGGTHHWLGVIDVDHFKSVNDRFGHLIGDEVLLLMARLLRSTFRHDDRLYR
FGGEEFVALVRADDAAAAAVAFERLRTAVERHSFPQVGRVTVSIGYTAVRPFDTPADAFE
RADRALYQAKAQGRNRVVCFESDVTPQAGQPLQHAGGNVDLF
>M5CVY0|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia RA8|TrEMBL
MNRLRVHRRHSHRLPDRGTTRRACCSAKVAPETAAIRAEPSLVSHRIMPVLPQAAVDGDL
ADPLPQRILLVENSRAFTGMLREAIEQRLELPVVIASTLAEADRLLSEDGGWFLVLTGLV
LADGDRDAVVEFFLKRDLPTVVVSGVYDEDLRKRVLQQQIIDYVLKNTPGSIDYLVWLVQ
RLERNRRIAALVVDDSPSARGYAAALLRMYGHEVHEAADGNEGLAAIEAHPAIRLAVVDQ
EMPGMQGVEFTRRLRTLRSRDKVAVIGISGNTDASLIPRFLKNGANDFLRKPFSREEFFC
RVSQNVDQLELIGTLQDLATRDFLTGLPNRRCFLEQSQRQLPQLQLHGQCVAVAMIDIDH
FKHINDTHGHEAGDDALRAVAGAVAAHARSQDLIARFGGEEFCLLVPDMEQDEALQYFEE
LRQRIAALEVDIGTATLRMTVSIGLCCLRPQRDALHRLISEADRQLYLAKAGGRNRVSCT
TVASPLRPREPALP
>A0A377Q9E2|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MNWTTRQSAFITLLAMLFGLGMIFILAYQVNSSYQVEIQRTRLEAAHQSSTIASQISSSL
REIDIILKDLSDKISPDDLSNTEKSSARNQELQNILLDKLLQIHQADNIMLVSSNSNISH
RALDTPGSGQLINNDYFQLVRNNRYQEKVYARLSNRSENTGIIVARRVESLMADFSGLIV
ASVTRNYLDNLLSNQNIGKHASIHLIDQNKGVLAKYPSHASAPIFDDFVIQNLMNGKESS
ALISHTEPTQSISSYHPIKDTPFIVVVNVSSEDYLLPWHKNTLYYLFGGGILLIMALLMC
YFFWRSHRLTQNLHKKEKYLNASEARFRQMIETSPVAIVLARMPDYFITYINHQAAELFD
QTQAGALSQRAFELYKSKLTFMEQVQRIQQGDAQHNIEVLLQRKDGQPFWGNLSMSVHET
NQSTTIMIGISDITSKKQLEADLQHRATIDSLSGLFNRAYFTERANHEIARAKRNQQPLI
VIMLDIDHFKKINDNWGHDTGDIAIQSLAGLCQSTLRDIDIIGRIGGEEFAILLPETDLE
KGFPVAERLRQRIEAQRILLTDKQTLQFTASLGLTILEEDDQKIDRILKRADQALYQAKH
DGRNQTVIFNKQ
>A0A377Q883|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MPLKPFIMLDAMADLTSLDDRDALLISLGISLQEIFDLERVDFYHCRPSTEHPQAVWQIK
KTLSLANGEIQQAWQWRPQNTLNSDSADFDPILKSALSDLNTAESIHFRLVRTLKMNDQP
HVLIDCQGKHLFKQTDLRALQGMTRIYENHISLLKYSETDTLTGLLNRKTLERHFQKIMG
SQEKTHAISIEDASAIEENNRRSQQEDDSYFLAVMDIDHFKRINDQFGHIYGDEVLLLIA
QLMQASFRSGDYLFRFGGEEFVILMGPQGESSAIFAVERFRERVAQTTFPQVGQVTISIG
FTRLLHSEVLSTVLGRADEALYQSKSNGRNKVTIAPVDTLNIHHPVNGSIELF
>A0A1Y2NDV2|diguanylate cyclase|EC 2.7.7.65|Streptomyces platensis|TrEMBL
MTECEDPVAGEGDARLRAVVELAQAMAAAHTPRESAHAAALGVRQALGGSFAAISKWERE
LGKLRVLVNTGELAEGEEEFPDDESYPVHEFPEIVGFLHEQWAGGGEPSAWVETAEGVHA
PAPRVPEEGPAGGGGGNRQRMAALRRRGRGCCVVAPIVLHGRAWGELYVARRTGEPVFGR
ADADFASVLAAVTAAGIAQTERLAEARRLAFTDALTGLANRRAVDMRLDEALELHRRDEV
VVSLVVCDLNGLKRVNDSRGHAVGDRLLERFGSVLSLCGAMLPGTLVARLGGDEFCLLAV
GPPADEVVKVAGELCDRAGELDLGEGVAVGVASTGDPIGPVRSARRLFRLADAAQYKAKA
ARSGEPVIAGRHGGKDDPVVRLADAPDRRTGPERRRFRR
>Q8E8V4|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MIRWQHLLNKLTTDDPLLQEKLSVWRIHPHKTPLALIQGFSFISANSATLDYFGTEYDTF
VNATPYDFSPRIQSSGRNSVEFAREMILEAVSGINVEFSWLHLNQQGNELPTRVNLYRCY
LQQQPVVLVELQALNRRTQVRPAIADGFAHIPKEILSTTLEESAEAVYITDIDNKILAVN
KAMCRICGYSAEQLINKTPFFLEASPLNASDESECLQALKQRGFWQGETLKQRSDGSTFP
AWQSSRRIAADGLEYHVNIFSDISTKKLLETQLTTRAMYDTLTGLPNRFHLKQILNGALD
KLKDDPLALGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGCIEKADIARMGGDE
FTLVLQDCSCKEEIQLFAEQILSLFDSPFEIEGQKFFLGTSIGIALFPTHSDQAGQLISL
ADTAMYCAKKNQPHLVFYDKSMSQAAELKLKLINNLRHAHSLKQFKLAYQAIVDLHTNKP
IAAEALLRWQKSPTEHYEAAEFVPLLEETGLIVSIGQWALEQACKQASVWRAQYQPDFKI
SVNVSPLQLEHVDFVGQVVNALEMVALPAEALILEITESALLRQPEQARHTLERIKALGV
GIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLTDASGQKLCHAIVQLAQALGIHFVA
EGIETQQQKDIITHMGQGFAQGFLFGYPSYVEQFTESYLAEKCIA
>A0A379BNQ7|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MADGRSMFRTWWQDPVDYRRLVETFGSHAALGRFKFMLGAGGIVMLTIAVLASIAQGDVA
GPVGEVQGIVEALVAGAWTVRWWFLPWPREKESLLWIVFFDLDTAANDVLVHDRVVGVLG
VVLLTAIGAYVTVFHGPRVLALHIGWTLLTSVVLATLMVQGALADNGPTTRTADLALGLA
VVLVMMVVVGVMLPFIQFSHWLLRKDALSDPLTGLLNRRGLDNRLPSYLGHGRRGAAYVA
TLDLDRFKVVNDTFGHPFGDEVLVCTGERLRAAADADALIARTGGEEFVVVGHLREDPAA
VGERLRDALATMPDLPVRITASVGVAVLDPCHPKAVYTPALYRELLRGSDSAMYRAKRLG
GNAVVVAEQNEPNSARPWRVPDRRAMADLRWHPEMLYRG
>A0A6G7TB95|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 29361|TrEMBL
MFPKTMNDENFYSKIFSREGIGQAYSADEHHRSGLRLARQLRWPRTAGLAILFFPIASVL
VAQPVNGVWWLLLVGWAFVWPHLAWQLAARSTNPWNGEMFNLKIDAIMAGVWIGVMGVNA
MPSAALVMMMSMNLIGVGGIRLYGPGVIMTALAALVSLQLTHVTPDYASTPLEIGLALPV
IVCYPMLFAWVSFHTTSRLVEHKRRLELMSTLDGMTGVFNRRHWEVLLRTEYENCRRYQR
SATLLLIDIDHFKRINDSWGHDVGDQAIVAVTRQLQLTLRASDIIGRFGGDEFAVIMSGT
TAESAIAAMSRVHERLADLQLPGPPHVKISISVGVAPLTTSMVHYQEWLKAADIALYKAK
NAGRNRTEVAA
>A0A6P2EAC0|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. RA8|TrEMBL
MSMKSGFSNLRISLNTRLSAGVAAVVLAATFAIATVALHLVKASMQASIANEEFARVTAI
ADAVDQKFVGRRTLLKTLAESVQSHDVPSAAPLQGLLEKHQSLREAFDNVSFIDLEGEIV
ANLNGAQMIGRANVKDRSYVADTISAGAGVISAPYRNRLNGLAQVAITQPVRDGAGQVRL
VISGSINLKERNILGELADVKFGKTGHLFIVSNDGIVIDHPRPELVLNQAGTDGAGDTEI
QRAISGFEGTTEGLDQDRVRALYAFKRMRQADWILGAVYPQNEAFAHIDAIERVAWGGAI
VLAVLAGAAALAVVRGQLQPLSQLHRRMLDAQAAPAEAAAPRSYARDEIGDLWRTFDELM
LQRRASEKFLRDITDNLPAMVSHADAQGRYTFVNARLCEKLGRSAAELVGQPMRDAHGAD
YSVIPERYLQRALAGEPVTFERRGSIRQGEEPRFFQTELIPDRDPTGTVRGYYAMSSDVT
ERKRIELSLAHSEAQIRTITDNIPALVSHVDASLRYTFVNAKVKALHKSDALVGRPISEV
RGPSDFAGVEPYYLRALAGETVIVETAGDAALGIDGRTYKAYYIPDQDDVGMVQGVFAMT
FDITDEVNVRKALSEQEKRLRDVTDSIPALVGYFDRDENCLYGNSRARQMAGLGNGPLEG
VTLRAAVGEAVYAQHVPFLPAVLAGQAARFPVEAPLYGKSGYFQVNLIPDKDLQGRVPGF
YVMTFNITALKEAEKLLAESEMRLRTITDNLPALITYIDRDQKITFANGTYREWLGLDPA
KLVGHHIRDVAGPELYESRKAMIDRALAGERVEFEAATKRGDFDRVTHVIYVPDVGADGA
THGIFSLSLDITELKVVERKLIELARVDTLTGLPNRLAFNELLPAAIARAARAERALALM
FLDIDHFKSINDTLGHAMGDEVLAEFARRLQASVRSTDTVVRLAGDEFVIVLENLDRPEA
ASMVARKVIARVNSAAFQLDGRGLDVTTSIGVAFHLPAGAAVTTAELLARADAALYRAKA
AGRNTFVLSAD
>A0A0W2H797|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MKAPATPENETDRLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGKAPDTVPRNISFCGHTILTEAPLVVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSVARRRAEPLTLGWLDLDRFKEINDRYGHEEGDKALKVMAQLMRSAFREADMLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVESYNARKLHPWSLHFSWGLSEFDHNGNDLQ
QWLKDADEKMYAMKQQRQRAR
>A0A156GL13|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQMLTSSAWESFYVMSDLILARVSETLATEQSLESLVRQLLEMLEIVTDMESTYLTKVDI
EARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTIFSNDVPERWPECEAAKALGI
TTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQSIQKESLVTQLREA
NAALIAHSYTDALTGLPNRRAIFEDLTTFFSLARHLKRNAIIAFIDLDDFKLINDRYGHE
AGDQFLIEVGKRLTEEKQQDDIIGRLGGDEFLVASLSQPHQDGDNAQLTLLKTRLSACIA
GEYWLGSVHIIYPGASFGVIEVDPAATDPDSALRAADVAMYQDKKGKSKSRFLTID
>A0A1Y2P1G6|diguanylate cyclase|EC 2.7.7.65|Streptomyces fradiae ATCC 10745 = DSM 40063|TrEMBL
METESEPYVRLATLRQLHQVVANLNTARSLADTLQTVADGVLTGLGYQLSCVNLVRADGD
LVVAAFAGDPAAEALITGRVGSRASWDRRLRMGEAWGDLRFIPHTEGWVLVDDDVPQWHT
DGPEPRFEDEWHPLDRLYAPMYTSGGQRELLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
ANDALCRLLGRPAAVMRRYSFADLVHPEDVGTLLRTSPEGGRAELRLARRDGTYIWVSLR
NSVVADTADGPRFLLTHIEDIEERKRHELQLAHRASHDALTGLPNSAELRARLSARLCSR
PDGRVRATAADAAGLAPAYGNGAAYESGAPYESGAAYEDGAAYGGAYEGAYERTYEGAYG
PGATGAYEYEHAYRADGFDFGPSGGAGAGAYDGHVHAVAPVGEIDDGTKGLAVLFCDLDG
FKSINDRFGHHTGDAVLIEVARRLTAGVRDGDTVARLGGDEFVVLADGLGAADAADLAVR
LRNGIIPPIRVDGRAVRVGASFGIGWAECGMSVEEVLNSADQRMYMEKRSRAKVQRRAG
>A0A1Y2NQP7|diguanylate cyclase|EC 2.7.7.65|Streptomyces fradiae ATCC 10745 = DSM 40063|TrEMBL
MDLPLIATALPALGWAIHSGVLARRLDRARRDPLTGLHTRAGWTTRAERILSTSPAALVL
LVDLDDFKAVNDTHGHAAGDAVLVATADRLSAWCGRTGIPARLGGDEFTAITRHTLDTDA
LRVALSQPVDHAGTLIPVGASVGVCHRTDLPLPSLTDALSAADTAMYRAKGHGRRNNHHR
>A0A8G1JSN7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MLKASLRSHLTLWFAGLSLLTLLSVGFYVGHIATEQMKQASGNALLSTARSAAALLGEQL
RERQLEVYLLSRAPHLERGDLDNPAILKSMQLRTQARAEYAWMGIADANGQVHQAVNGLL
VGQSVQQRPWFQAGLRGEYTGDPHEAVLLAKMLPALANGEPLRFIDFAAPIHNADGQVIG
VLGAHAHWSWVTRIVESAALSHKGVAPDIEALIVDHDGKVLYPEALVGQQLAANNPDSPG
WTVGDGYLTSAVTVPTPLSTALSWSIAVRQPLDTALQPARLLLYKLLLLGVMAAVVFALV
AYYLALYLSRPIEQLARSAQQVQNNQPGTRFQLQHPVREIAQLGQSIDTMTQSLLAKERE
LQEANASLEATVAQRTAALTQANAELLSLATHDGLTGAFNRRRFDEKLTEYSLLFRRTGR
PFALLLIDVDHFKRINDTHGHAVGDDVLRQLAQLIQISTRATDFVARYGGEEFAVLLPEI
AKPDTPEVVAEKIRTTIAETTFPLVGLVTVSIGVGLADPADNSPTALIKRADQRLYKAKA
AGRNQVACQASLIEVSENG
>A0A8G1NGS1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MESRNSAPLASYIDLLLDAVCAVDKQGRFVFVSAACERILGYTPDELIGQSMIDYVYPAD
RERTLAAASDIMGGEPKHNFENRYVRKDGSVVHILWSARWSEVDQLRIAVARDITERKLA
ESRQAALYAISEAAHAAEDLLALFKRIHMIIGEWLPALNFSVALYDEHCAQLNFPYHVDD
DELQPEQPGTVTGRLCAEVIRSRQPILLTPDCPHAPPEFAALVAGQQSPCWLGVPLSSKD
RTIGALIVKSLPGGERYTERDKELLQYVCAQVATAIERQQLHARLRRMAQYDQLTQLPNR
ELLRERLKAALNHAREQSGHMALLYVDLDRFKQVNDTFGHTVGDMLLQAVANRLKGCVRE
TDTVARIGGDEFVVLLHSVHAADDADSVAEKIRQVLVQPLRLDGHNLHIEPSIGVARYPE
HGREEQQLFRHADQAMYAAKRLNHRALDH
>A0A5C5WYS7|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus neptunius|TrEMBL
MNSSLLLESVLQLSKASELPTPPNELDDIISIHVLRRLLAAIHFRDVRVLKHSRRVGLLA
VGIGSRLGWEDMQLRLIEIAALLHDIGKLGVPDHILGKPGKLSPDEYEYIAGFNRVAVEI
LQCCQVNTDVVDIVAQSHGVNVDGTSTQDKPASLGARILAVADAYESLTSIQPYRPAFDT
NKALRTLEEQAGKGFDRNVVAALERWLHSERASVLSDTDAENASIAANAPADHNAKMAAT
RFCHVFQYLHTLESLYDAFYMIDREQRIVMWNMGAVKMFGYSPGELIGQTWHRSIVSSTK
AKPDPVDRCLEESIPVCHRLNLKDVDGNSQSFDVQTLPVTNDSGSVRAVMELICDGNESK
RHRGQFRKLQMAATRDALTGAFNRGELEQRLTQAFQKWEKDPQIPYSVVFVDLDHFKAIN
DRLSHAVGDRVLIDVARLIQDELYSGEQVGRYGGEEFVILCPETPLEVAIERSERLRRSI
SSAEIAGRDDLRVTASFGVAQVEPGDTSESVTKRADQALYDAKNSGRNRTCYRVTEQWAE
SQKKNEAGEDAFIHQAEIVACVARGMLPMKLKGYVEDIHAKILSVKEEEISLQVGAPTLF
RKWGKEDDKQPVRVRVEIHDIPAHEQKQGTRRLRLKTFTEPVGKPSSPEVFHKRANRVNE
SLRAYLIAD
>A0A1V5XYF8|diguanylate cyclase|EC 2.7.7.65|candidate division BRC1 bacterium ADurb.Bin183|TrEMBL
MNIVKNVNKKFKKMSDKPQENTEFHSEETTCPFMDFSKNADTTGVNKPRSQKEGREEISS
EGARWYPLLLLIKGESVSERYLLDKEDIKIGRDPAMDISILSDDMVSRRHARIIWNNFND
PQEYPLCTIEDLGSRNGTILNRALIKNKTRLSDGDRFLIGRTVFGFYIKDDHEVNYDNKM
ISRARFDGLTGLSNRRTFQEDARHCIAQAIRQNNPLCLCLMDVDSFKEINDKYGHVAGDY
VLRQVSRDMNLNFREGDIIGRLGGDEFAILMPQTPVAAAQSAVERFQQDIAGRPLAIQGK
QININLSAGIAAINDEITKWGDLYRAADSALYEAKNSGRNRVCVFAGNMIEQDVSDVGDE
>A0A1V6EFV0|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin099|TrEMBL
MLKNKRIRIILISTLVALVISALYMLGIISDEIKLFKMEATSVLDNQVASIRNEFMVNIN
SVYELRALVYGARGKYVDPQIIGERILKNPNIRNILYAPDSVVTNVYPLEGNEAVIGLDL
LSPENKSCEDAKLAVQSEDVVLTGPYELKQGGQAFSARLAVRIPDENSQLKYSGLVSVTM
NFPDLISESTNNLHNSLKYDFILEKRLNDSDEYIEIHSGRVSKYDDYISSDFSVSNMDFR
LSVVPQSGWYDKSGIMIKILAFVVVSLAVGIIMGFIFAARQKLIEKSRTDALTGIYNRAG
GTHAINTIIKNNLYKSGAFIMMDLDNFKSVNDQLGHQMGDEVLITTAAILKNSIRATDIL
ARLGGDEFMLYLPFEGDSDFLDKKLEEIRIKMHRDIKGTEGVVTVSSSIGVTFYDKDKNF
NTLYEQADKALYQSKESGKNRITIYEAKSDIG
>A0A1V5XF38|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin193|TrEMBL
MLKVLNKVLDIIGTGVIIIDEEHKIMFFNSAVEKLCNIPEKEAVGKSIYEVCPVFGQEMY
KSIIDNVFKTGQSRFCSSAIHKSFVFPKGEKRESRRQNMKIDYLSVNAKEYAVIQITDIT
DIHKNELSLHEHIKTLKTGYRDLQFSKKVTEKLAKYDTLTGLLNRFYFEVEYNEMLKTIK
EEADKVAVMFVDLDCFKQVNDNYGHTVGDALLQQAAARMKNNATKPDLIMRMGGDEFVVA
CKDNVYGKTFEGIANSMLIALGKPYYIDDVVMNISASIGISIYPDDSKQLPELINKADKA
MYASKQSGRNRVTFFYEIQK
>A0A4R2XV71|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MVLEEAYVDNQHNNLENVAHEMDGLLQFNTDRMIFFRNGMQSALETPLDFTILRKAEQEY
ISKRHEAIWSVALHNRRTLPVYGVSDAFVDKAPTLSRDNTLSGNELMATLELGYLLRLTN
NNRGFTERMLYVSRSGFFVSTQALTNTTQALALYSAATRSPWFTRQSQRTNPGRGVVWQT
FPEEGALRDAQVVTASIPLDFRHYWHGVLAMDFSVREMKAFLVNAAKGGQDGEYQLYDSR
LNLIASSAPGNVLTLLSPREQETLSYAFSHDNKGGIRLLTRYISWQKLNNFDGVLLRIHT
LQEGVRGEFGSITIALMLMWLLFTSMLMISWLVILRMVRNMSELQTSLEWRAWHDALTRL
LNRGALFERAIAAAGECERGKRPFAVIQLDLDYFKRVNDLHGHQSGDRVLSLVASTIASN
LREGDLAGRVGGEEFCVVMPDTTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVS
CSEDCAEVNFENLQSIADRRLYLAKQNGRNQVCSVG
>A0A6I2ISK6|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MIAVSGRVLVLGNALQRVIGRFKNPQKVVNLCFIFVFLFSTVLTWREAVVLEGAYVASQR
NSLDSVATLLDRQLQHSIDNLLFYRNAMLYALQSPISTDRTRKSLADFDTLRTQPFWQLR
LDLSRSLPMSGVSDEFVNKSPLLDRDEHTLHSELSSALELSYIMRLSDSSGKMPQRMFYA
SRSGFFLTNTPPANDPNIVSLYYRLIARPYFSSQSLQNNPQRSLKWTHTFNGNDTSGQIV
TASVPLDFNGRWYGVLALDYPIESLHNFLRQAKYDDHEGTVLLYDNELNPIATSARSLPQ
HELFTAPQLARIANVVTAAKQGEQGELRMDSRFITWAKLNNFDGLLVKVHTLEEGVQGEF
GRISIVLSILWMLFTLMLFASWMVIRRLVNNMFSLQQTLSWRANYDTLTRLYNRGAFFEI
ARKLSQECEQQGLPFSVIQMDLDLFKSINDRFGHSCGDKVLIHAAAMLSDAFRTGDIAGR
VGGEEFCIVLPETTLEEATKVAERIRVRINTKELLIKQGNTVRISASFGVSSSFEFNDYD
FERLQTYADHRLYKAKQGGRNQVCNHD
>H6RL90|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MTSAAEPAPELGRTGAAAPDRELPVMDADPALDGLVRVAAAVTGMRCAAVITMDTAVMRV
MAVHGFRGAAWPREGSIVATVLARGSGVQTCDDLILEPGFGRSPWVDGRRGRMRAFGCVP
VLVDGVMLAAICVFDDAPHTFTDEERGRLADVATAVASLVRAGQQARQLADLAAASHLAR
AETARAHQQLARSTAFTRALLEVLPVGVIGADPEGRVTLFNATFRDWHGLDVDLTVEPDD
LVETFSLTDTDGTPLQPDQVPLRRVLADGRLDATEIAIAVPGRPPRRISTSGARVHDDDG
NLLGLVLTSTDVTEQRALEAALREAALHDPLTGLPNRNLLLDRLDQSLAAAERAQRPMAV
LYCDLDGFKPVNDSAGHAAGDEVLVQASRRLAAEVRPGDTVARIGGDEFVVLCPEVGSEA
AAQVIADRITAAFDAPLRRAGGAEHAVGISIGVALCGPGHTADSALASSDAAMYRVKAAR
RRPRGRTPATV
>A0A841KRT1|diguanylate cyclase|EC 2.7.7.65|Oleiagrimonas soli|TrEMBL
MSPTDPALAPSEVVVRLADVISQADSLENLVRPLLELLESVTGLESTYLTTVDLQAGMQR
ILYARNTSSLQIPEGTAVAWEDTLCKRALDEGLRHTDDVPAIWADSAAAKALGIMTYAST
PVHTPDGTLVGTLCAASDERKPLPTGADRVLDMFSHLIAQQVERERLIRELREANRLLSA
TALTDEGTRLPNRRALLAEMRRRRQDASSASMELLVGYIDLDRFKHINDTHGHDTGDHFL
RAMSARLRRALRGDDFVARIGGDEFVVLSSVPPRQVDKALSSLRERLRRTTRGRFHLDAV
VLEYAGPSIEVVVAPREVEDPESVLARADAAMYEVKRARHAQR
>A0A8F6D3B5|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVTGAGIWFGAIYALVI
TLLVLFVLGSLLLWFQTGSFMASAVAESLQVLVIWGIALLLFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETDRLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEEHMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAEQFLNELENEMMMNEL
>A0A378HHA9|diguanylate cyclase|EC 2.7.7.65|Levilactobacillus brevis|TrEMBL
MSWTMWLVPPIITSIFFVLGVITLYWSIFTWATTKAESQSKPVNVQKVQIAVGTICAIIS
VFALQLLVRDSHLGWTFVNFQLLLLLFVAYFLQLKIPYWLVFVVAIGFMLMNGNVTAPLS
WVFTLVFVGFYVVAYQHSIHLWRWPYTRYILVALSFGLVLWLLVKMRFHLPWVTYWIEMV
DYAFLATLMYGYFKIQDKDRRIKDRLFQSANWDALTHVQNYAAYDRAISYHFHRSLIRHN
DLTMAMFDIDHFKCVNDTYDHLAGDEVLKQVSSTVVDVLKAKDEQIVLYRTGGEEFNVIF
PGYTVAQAQPLVQEFFNRVKALKIPYNDVELNVTISVGVSSLHRTDHNPLDFYKRVDSHL
YRSKKMGRQQITLE
>A0A4U9CYC8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKDYPKGPRPTFKRALRRISMISVIISMTLVWLLLSTASVFTLKQYAQKNLELTAATMS
RSLEAALVFGDSAAAEDTLATLGKQGQFSKALVLDSQKKHFALWHNHDLVSEEKLSGLIS
KWLFPQPTVQPIWHEGKIIGELRLTALDRLISHFLGISIIVLTGSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQRAAAGQ
KRPASAQLSARSADRACQPRGVS
>A0A5A8IW12|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQSWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4U9CYS1|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MGIASIAISPVIVAVSVQAINTLVRQLSHQVRYDYLTRVYSRFGLYERLKELHDGERDTP
LNVLVLDIDHFKNINDTWGHDCGDKVLAAFAVRVQNVVGQRGIVARLGGEEFAVIMAGKP
GGEGYLLAEEIRKEIESMQVEWGSKMLSLTVSVGLSYGKAMRWNIVDIFDKLLSEADAYL
YQSKKMGRQSHQRPAGNGHQPAAGVNLIILPRAIGRVISSLHSQRIYKVT
>A0A3P8IVN2|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLSDILSLHFYEDNITISVVDNNGRIIFSRDTTQKGSFLPLPAQIRTALQANKSGHYTGF
YGQHKSLVGYASLNQTNWNIFVSTPANTVTRMLWLTVEKISGFVLVILLLVAGSVALLSS
CIARPLEQLAGRVRATDSLTSPEKLSAIRAWYQEADMLRNAMQNSFRSVSARFATLSDEA
MTDPLTGLYNRRGFYEQSARVGAAEDQYAIAIDIDHFKTINDRFGHETGDVVLVRIADLL
KQTCRDGDIISRFGGEEFIVLLPDSTRNGAMTMAERIRRVMAGATFSRAGHITISAGVAG
LRECAGDREKLLRMADQALYQAKQQGRNQVVFSEIIPEPGSQ
>A0A6C8EZB6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Virchow str. SL491|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A399E774|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MLGAIGMNSLESPQQRAYRLYWVIAALVMVPAVFIHPFFGRWPEFLLDGTYAAATVLGWW
LARRLAPKPAITLHLVLGFLLATWYIAQPEGLPGRFDFREEAYVALVAPALLGLSVVWGV
WGFALAVLMGFSRLQNPTLPEQLSAGYVLAFVALLGLVTHYSLRRLEEAHENLANAALQD
PLTQLGNRRVLEADFVRLQALAKRAGVPLLLTLWDLDDLKAVNDDQGHVAGDAYIRDFAQ
ALRLNVREGDGLYRLGGDEFCGLHLGLSEGSSVSLRVRAVFPNVSVGWSEALGSLDETLA
QADQHLYAEKANKRPIRMPKLP
>A0A517R538|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan189|TrEMBL
MVDPQKIWSSSQLPTLPAVAVRLLDLSKNPDAEVNDFIEIIRTDPAISAKILKATNSSYF
GFQSNVTTIDRAVPLLGTTVVTSLALSFSLVEAAMTTGPMVEHYRDYWMQSVIQAATAEL
LATKTPGSLGSEFFLAGLLCDLGRLAMLKTVPDESRQAIETARERGLDLFATENEMVGVN
HVEVGLKLMESWTLPPATILAARHHHDPLELIQQHESANDSDLIHATAVASSVGDYFCGA
NKGQALDRLRVLTAAFYDLDETELEAFLSEAKEKIDSVGELFALNTEGLGDPHELMAQAS
EHLTQLALRQQAAAAEAVARQQKLEEQTRLLESKNKELTQQAIRDPLTKLYNRAFFDESL
QRELDRCARAAATIGVMFTDIDKFKVLNDTYGHQFGDQVLKQAAGLLGGSIRKSDVLARY
GGEEFVVLVAAPTEKGIAKVAERIRAAMEAAKFVFEGEDVPVTISVGAALAIPQRDTAEL
AEKLISEADEAMYDSKKNGRNQCHVRVLLSDAERVLMQKTTARRFSRWLVNRGVFDIPTV
SKALVNFECPHVKIGDLAVRRTVLNSMEVDQILEQQQSSGKRFGEIAMQLELLTEDQVAD
LLAWQSECPQTLAVELVKKGLLERQAATMLLKTYIAEAPAPRENAMA
>A0A399F6G3|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MSDVRSKLPEAELLAAVLEPMAMLDEHSRVLAWNPAAERALGYSPAEALGRPLGELLGVS
LPEEELPAAAPEWEGGQVVEARGADGQLHLLELSLRTYPKDGRTLYLACLRDQTPLHRAR
QEVKALQAETERLAAQRTTLEASLRESAYLAALTGALERYEDLQPLAGEVVRRLRPLVGA
DWITVLLGNPKEGFQPVAFDGYAPELLRSFTERSALLGQDDALTLELAQAQPQFIDDYRG
LTRTYPAHLAAGVASVAWVPFGQPEQEFGLLGAFRLGTPRPWRLEEQGLLEVTADALSIS
AQRVTRARQLREAAQYSEVLLQISRLTETALEVEEVAAEVIRTIANVADVDWIGLAVVRG
NSVGLRKVWDSPMSIPTADMHKEISPVWEAIEAGNPVYIDDYPGHPRAMAALLEVGVQTV
AIIPLTLGERGMAIFAAKFGPDRPWTQKDRSLFEAAARSVRTAQEHRDYLRAVEAAAFTD
ALTGLGNRRAFDRDLDAALNSARRHGYPVSLLMLDLDGLKQVNDTQGHERGDALLRGFAR
ALHSTLRREDRIYRLGGDEYAAILEHTPSGQSTLAAIRARVDQAIAVLRSGGFPDADVSA
GLAAYPADTADPQELVRLADERMYEEKALHRARRARPDGGGRG
>A0A517WG17|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MYFLIASIIEVFTNHVASGASSASVLAIASVCLLQYVVYTMKMSAVRKENAEFQQHYHDV
EEELNDVQSDRAMTLIENHILREFVAQSEFDQTIDLLLKRYVPSIREGLGLYLNRVNGEF
KVRDSRGITRNSKAVFEFDERQLKQLKTQNVIILRGQELRNSKIYQCFDEQDKPRIHKLC
LLAVYDKNAISGVFLTTNLYPDGVDEQQQIKLAKRLLVCVSRNIVKNQDYESYRFELRVT
REQLELRALADQQFKTPVIMLEEFLDRLRQLTNSSRASLFLSTPHDFSNCKSIVDCGMTL
QAGVKTRWKEHELTLVRLGLNSGENTSLSGEQLENHGVRSLIGAALVSPLITNRKRIGAI
CLTNQECQPFDERALRLISWASQFLSNTLLKVLNHANIEKQARQDGLTGLVNRRSFDELI
DNAFGRAQAAQSACSLILIDLDHFKSINDTYGHQAGDEVLRRVARILQDRIKEIRSSDNV
IAARYGGEELAILLPEIGLAGAERIAEVIRHSIETATIEFNDTRIPVTASLGLSTYTSQA
MESVQTLVAAADGALYQAKSDGRNRVCSLTSAPV
>A0A737BUL6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica serovar 45:a:e,n,x|TrEMBL
MFPKIMNDENFYRKAVDQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAITLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIAHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5C6AHT8|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MHVAGLGRGLNLGESTMATPSSPGNAMKSRSSQTDMRVDPKPDVSPFEIAKQALGHVGRF
QTPPTPSVYEVWYRYVEGVDDIIANLSHAVEDVNSVTVDMLDQLHKQYCVPSETSNQMMA
EELIGEMSSLQAVVDDQIQAGQTFGDSINEACDSLNQDNPSLEIVAACAKTMLVSNAAMQ
QQIKQLNQQLQASQEKVQALQHELIDSQRATMTDPLTGLGNRRHFEIGVRKSLVANDRDQ
RNTFLFVIDVDHFKTINDTYGHECGDKVIKYVASQISRHCTQGSISRIGGDEFAIIVDVA
DHQEASEIATELRKFFASTPLKLNASGDDLGTIKLSIGAACLREDDDEKSWFVRADKLLY
QAKDGGRNNAVVEHFR
>A0A4P6WNH5|diguanylate cyclase|EC 2.7.7.65|Citrobacter arsenatis|TrEMBL
MIKDTKEIDAILIALNKSIDAHYKWLVKMFRCAVSSDVTQPDIMADNSHFICQFGQWLNS
QSLHNEDDCSYVNKINAAHEKMHLLGKELLLAIVDNRSHLWQFDSFQDALLAFTSAVMDY
KIYLLSIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDVVLRALASNLLAWTRYDEVAYRYGGEEFIIIIRTKTDEQASLAGLRLCQLIGQKKIPY
ADGEIGITVTAGITRVQHEETLDTALGRADRAMYQGKQTGRNRCMFMDEREQISLVDSND
GISYPLSA
>A0A1V5PWH5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MAIITVIVVVFLLLIPNDNVFLAFNASNLKKFDEGWKMSDGGDIEPDDLSDIARENGSSS
GVTIVNTLPADLERNDSLNFRSRNVDYKIYIDGELIKEFDPYIPRIAGKSYGSAFHHITL
PEDAAGKEIRIETGFLYEDGHCYIDMIFLGDGGDYYHWLITSRLPSFLLSIIIIIFGLIM
FIASFLVKEKSSERSMFYLGLLGIVVGFFTMSDTLFMQLMWGGTLFWHCIAYFGQMLLVY
PGFCYVNSIMLRPEKMYDRIVFVITMLQTVVCFAATAFGIADYHSLLILVHIYQVVIVTA
IVVFLVRDAITYKRLKTRNPNSLVYMAFIIFLVTAAIDMVSYDLSVGSQSADNNRIMRVG
ITIFILSLSVRSINTFLIKMKLANESAVLSKIAYTDPLTGIGNRAAFIRQEEAYEVDIKE
GDIKGVLVGMFDLNGLKQVNDNLGHSAGDAFIQGAAEVIKSSFGPDCGWYRTGGDEFIVL
MAGTLDETEEKYQNALKAMGSAEEAFNATSGLGVPLYIAHGHAYAGTENGMSVVEAERIA
DSRMYEDKKRSKSARKS
>A0A1V5Q4U2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MEPELDRVINGVYEDKQDTLVALVGGRIEQLPPADKDNLVPGYVKKDGEQNTFFFIPLHD
GKHNYGYTIATGTAQLLDSGYSLFYYNEKIRHGMLQLRTNLRLNEVNSELTELYDKDPMT
GLFNRFCYEKKAVPLFEASHSDHSRIMIMFIDINYMKKINDVYGHLQGDNAILKVTEAIK
SSIEEGWLPIRYGGDEFVVIAPEASEEKANDVQSSIMSYLDRVNSEEGSQYSISVSCGYV
LTDPDKDDKLQDYIKEADRLMYELKKKRHEKDSESRQ
>A0A1V5QD80|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MVIIFLFVFLIINNRFEHELTVKFWPMLVMLLALVVFDNIDYFEFDRNNKGFFHVFAAFM
GYNLRIFILYRLVVIVMRDMPFKKKKIFMAPAIINLGITFTAFFTKLVFWYGPDGSIMRG
PLAYTPHFTLLLYMLICAWLSIIFIRQGNTEEATIVIVESILAILGTFVEFMFSLRGILI
GVISTNITFYYLYIHIRYFRYDVLTGAYNRNSFFADAQKYADNITYIYSIDVNNLKKVND
TEGHQAGDKIIRGTALVIRSILPANCYLYRVGGDEFCVLCTDISRENVALFTNRLRQQQQ
ESEFSFAIGFHDWHKDFETTYAEADKAMYDDKIRMKAGRTD
>A0A1T4R927|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MATLIKSTQLQATNFAYIELSEKTLKKQLSLLFPFAGAICAIIAFTYFVSQQDHYFTIVG
IVGMVLCYILAALNRTLFSATILFWIFLIATTLVCSSGFYFTGARHISNTIGLTIPLLSF
FALKIKTATWYSGIFGLIYIVLSVSEIADKHIQISSALQNICAYSIIFVMAFLLSRHRYD
AILQVKKTTTNDFLTGLLNREGLLPFYQTESARCKRYRRDISMLLINIDKFRDVNDRFGL
DAGDKTLMMAAKCLREICDKNIHIARLSSQEFCIIIPDANIQAAEQFAIKIRDEISQWIL
ELTTGHQIKISVSIGITNIEYQDFRYDYIKAESALMRAKSWGSNQIATNE
>A0A0H5LU05|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPKTPAITLPIVMITAISLGTIAY
LILISKKYADKLNYFSIVLGVLWAWQIILKYEYLGTNENNYLLFSLFTIFFISTIALSDN
FIAFCLHTAPATLAVIFLDDFQNIFRILFTIMLPLIGFSLHHLMSRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVEFAGKEFSNAEPSP
>A0A449UN16|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MKEQLIFNITNLVTVVFEAFVIHMFLSDFLGQKEGYIKVVRYAKLGFIICLGLCNLITLN
PKITMPLIFILIFSTSFLYKGNLKTRLFTTVLLSIFFILSEIVVTSIFVLFIKEGFEIMF
ENNSIRVLATILSKIVFLLTCKIICLFKKDVHLDMPIKYWFPLFLIPIFSLFLSVSVFDV
SKFFSLECLKFLSLISSIGILYINFIVFYLFKFIIDKTKLSMKYEILEKEIIHKEELRLS
NERYKIIVEQTDSVVFEWNIKENKSFVSQAWNEKFGYNNVCKNIFKEIKDKDLVHSEDNA
IFENFLESIKKKNRHNQAVYRLKKSNGEYIWCRTSITSIYNDENELLRVVGVIVDVDSDI
KKYEELKTRAESDSLTNIYNKGTFEKLVEETIVMNTGDKKDALFIIDLDDFKEINDNFGH
PFGDFVLKTFADKIQASFGSRDLVGRIGGDEFVVYMQDYVTEVNLHKKAKELNRVLSDNY
TDLSFSFDASVSIGIARYPQDGTSFFELFKNADRALYSIKASGKNSYCLFEEELYVQ
>A0A0S3PX95|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MQNSFLHIQTLTLVTMLLTTLLAVLLMISWWRARSHKILAWWAVSYFLGGTGTLLLALRG
SIPNVLSIEVANALVILACGASWCGARSFEGRPVRTGTIIAAALGWIAICQVPLVADSVP
VRIVIMSAVMSTFIALGASEFWRGRSEHLVSRWPAIVASLVYAAALLSRIPMLQFVDLPT
APLLFRGSSWFGLVSVVSLIYIVVMGCNVLAMAKERMELSYRHKSRTDSLTQLFTRRAFL
DESEAVLQEINRSGTTAAVILIDLDSFKRINDCFGHLVGDSVLQRFAATARKMLRDIDIV
GRLGGEEFAIVLPGLSPHEATVVAEQLRFMFQREAIEVEGELVGATLSAGVSFAARNAKL
ITLLADADRALYVAKEAGRNCVRVASVDVIIEAPPVTQPRAA
>A0A0A0FCZ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli G3/10|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHC
>A0A174DMV1|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MFLDMIGTMLISLLKIRNTFQKEQYNASMSSYSALSEIYLCMHLIDIKTGKYEQIKNVKH
VEKECEELDQENFSKRVYTTMKYFCTEMYLSSVLEFVDLSTLDRRLMETNTIVHEFIGTV
SGWCRERFIKVDSDEKGRLWHVLYCVEVIDEQKRREKKLLYLSETDSMTGINNRGSGERK
ITEFLEKKKGGLFCLLDCDKFKKINDTYGHAVGDTVLIKLAAVLQRACRENDIVMRLGGD
EFAMYLPGMPDKAQAESFFKRLFTQIDKISISEMQGEKINVSLGASLYSDKDRATFDTLY
HEADAAMYESKKIVGNHAIIYSDLPQARQTPL
>E1IT61|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 145-7|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6B9BJ16|diguanylate cyclase|EC 2.7.7.65|Mycobacterium avium subsp. avium|TrEMBL
MSGHLASQPSAGRWHAIGLIAFLWLVGIYSVKARLGGAGDPRLYGLLGGAALAAVAAALV
GRLRGRQESRALLAGWPVASLLLTTVVGAVDPAVTRDFPGTITITFAYIGLTCPRWRSLA
FVPLGVAAFVVGGAKALPDGSTSVLLAAAMWVIVAEVPAWLIARLEEQSALLRKVAHTDA
LTQLLDRSTLGPRLSAHASESAVVVIDLDNFNRYNDTHGHSAGDELLVAFADALRWSVGA
DDAVFRIGGDEFLIMLVGADREQAERVLDRLRGRWAELGEPVGFSAGIAAGAQDLMRLAD
EHMYANKRSRDLSAD
>H8FVK1|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MARHLDDPTDKQKLHRLAERVLKKRPVAHNLSADDPQRLIHELRVHQVELEMQNEALIEM
RAATEEALERYTALYDFAPVGYVTLNRTGMIERANHVALTLLDIPQHQIGQKRLEAFISD
SSQSDLAHFLRSLPDNSGIERCEVALKPTSANLGASIILEGRCGQPGHGDNIALIDITKW
RKAEQLLSQRSLELQQMNQALSISVSDLIEARKSMEIMAMHDQLTGLANRHKFLQTYAVE
VERHNRTLRPLSLLVIDIDYFKNVNDRLGHLAGDTCLRALATLMERNVRTADLVGRFGGE
EFVILLPDSDAEGAVAAAENLRDEIKSTKLDVGNEGLYLTVSIGTATLEAGQPVDFDRLM
RRADRALYRAKAAGRNMVTMSTEADDTNAPLPFTPPSK
>A0A1V4W9I7|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin027|TrEMBL
METTRDFFQGTEAAPILTRNDNDTALANPEHIFSFLSLTQNRAGDQPMSIAPFKFRSACK
RAPVGMSVVKIDDGKVLLSNPAMQNLLGYSRQELIGMPFSQFTHPEDVEKQKEAYLKIKS
GKRVSFDLKKRYIRKNGTSFTAHLVSTLIRRSDSKPQVMIEMIMEEA
>S3J6F3|diguanylate cyclase|EC 2.7.7.65|Cedecea davisae DSM 4568|TrEMBL
MSHFHQPMEKTLRITHVCFLSLFLLITFLFWQQGELFNHGYRTSQLSHLESVIARLETKS
QYQIDNLRYLRRMFIETLDEPLFTPLSRLSMLAGDKKGMAHLWIRNLPIPDSVAEPEKND
QKELLTRREYQALREIQDLFPLAGGGNHLSSNIYYMSRSGAFIASLSQEVNQLLIESANP
LHQQGSFVLGSPLLNPSRGSFWTRQNIPGTNQTLINGSLPVDFDNQWIGLFGIAVTAETL
QMFLSSSLPEGTQSAYLLFDEQLNPLTQAVGSQNGYRLSEPQRQAILESLSHASRGTLRF
SHAYVTFGKVMGTGAILVSIQTIGQGLHEDFGRFSVLLVVMWLIVMFILLGSHRMICRLV
RNMGSLQQEMHRHALHDHLTEVLNRRGFFETTARISPHYVDYSLIQLDLDHFKRVNDRFG
HQVGDQVLSHASRCIQQAIRSQDIVGRIGGEEFCIYLPNTDLHAAVAVAQRVRKMLVNTP
LKLADGESLLVSASLGVASHEEEPEGTLEQIQSLADIRLYYAKQQGRNRVCWREEGELQA
>A0A603BIZ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 50:b:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A427EW94|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. s199|TrEMBL
MQHIPNEQLAGEWRRLLDQFSPEAAAVLHGVAEQSNEDLAAHFYEQMLADPHAAVFLSHE
QVQNRLSHSMQRWVLTVLTSRPEDDLEAVIDLQRTIGDVHARIEIPVSLVLRGARYLKGR
LRRLVERQAAEAVTRRNAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFAVSQNQ
GAEKERQRAALLDWENQLMFDLAVGSGYESLPRLASSEFGLWFRHKASHAFQGTPESASI
LDYIMQIDQELQILADAGKEQGSLGSLHRVREQTRSIRFLLDSLFEQANELEAGRDVLTR
LLNRKFLPVVMTKEMLYSRQAGGSFGVLIVDVDHFKQINDAHGHDGGDQVLQQVATALSN
NTRGGDYAFRLGGEEFLLVLVDIDAQKITQAAEKLRQRIAEDSFRLPQGEVIKVTVSIGI
AVHDGHPDYERLLRRADQALYEAKNAGRNRCVLARND
>A0A7C8HVP7|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MISCFIYMQKRLHNLRPEGLENLTAELDTLRQLILTHAHSTPTPQADQQLALTRLIPGLT
MDSWNALSERYGFSEWLALDLDNSTYFNLANLQKVIDDLTHKSERDPLTGLYNKQAFENK
LTMELQRVERSNGQLSLAMIDLDNFKNINDTYGHSCGDEVIRTLADLLDASTRGYDHAAR
VGGEEFALLLPGAGPIRAKAMLDRLCSLFADTFIKCKDASVQCTFSAGVASLKGRSKASG
QDLFEVADKALYQAKNAGKNQVRVTRQLIEFEYDRSTMVHSNEKQFLFSGSK
>A0A0T9NTH2|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MSSIKNKSAGQAKHHNAPTNLPTLGRVLGRIHLIVALVSVVTAGICLTLAALLALRVYVD
HNLHLVARSISYTTEAAVVFGDSMAANEALALIAANEEVDNVKILDVNGRELASWTKPDT
SPMHYLEQQVARCTLPDPVVLPIIHDGNEIGTVVIAGHGSNLLRFLLQGLAGLLLCLVLT
TAVALVLSRRMLSGVIGSLNQITRVAHNVSRNRSFGQRVPSAKTAELNALSNDFNELLGE
LEVWQAHLTQENDSLAHRAAHDSLTGLANRAFFEGRLSRTLGDCGPGEHAAVLFLDGDHF
KEINDNYGHAAGDVVLTTIADRIRALLRESDLVARLGGDEFAVLLAPIHHIKDVSIIASD
IHESMSQPIMLADGCEITMSLSIGIAIYPDHAQTPEALLQRADEAMYQAKKNFQSGGSMI
APPSDSPLTESLG
>A0A7H4NLA5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MTNWAYGITVALTLASGIAMLMASSADNAERRAVEQRQAFDQLSEEVESGAWELSDLARL
YIIQKNQDVLQEYRQQAQATAAIEHRLEKLKDNGATAEELALLREGLQIADELQDEQQTA
LAQVARGEEKAAVSLLYGAAYEQELERVQTQLDHFRLMLEGRVNKTIAEATEKSRIWRTL
SEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAVRELLARMTQRLQGCESFEDVIKVAELFAPNIAPE
IPGRLYILDTDPWQMRCVAQWLSPPLEADVFHPDNCWAVRRGLSHPPVNGEPDIACYHLS
ESQAQRSLCVPLIAQGEAIGLLSFSNVTSATAPSRAYLELMAEALGLALANQRLRNALLE
KALFDSLTGLRNRHHLDDALHTQMNLAVRNGTPLSCLMIDIDHFKAINDSYGHEAGDLVI
KNVAAIIQRAVRDIGMAFRYGGEEFLVLLGGTDEEAAMACATDIYHSVQLLTLRYGLAEI
GQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGMLKAD
>A0A7H4N1A3|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MRCVAQWLSPPLEADVFHPDNCWAVRRGLSHPPVNGEPDIACYHLSESQAQRSLCVPLIA
QGEAIGLLSFSNVTSATAPSRAYLELMAEALGLALANQRLRNALLEKALFDSLTGLRNRH
HLDDALHTQMNLAVRNGTPLSCLMIDIDHFKAINDSYGHEAGDLVIKNVAAIIQRAVRDI
GMAFRYGGEEFLVLLGGTDEEAAMACATDIYHSVQLLTLRYGLAEIGQVDVSIGIASYPQ
HTQSDSLLRAADAALYRAKELGRSRIVSFGMLKAD
>A0A8E6IJP2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADDQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLTREIEKDTLGGLRLGMHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQHSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAAQEREKK
>A0A1Z5I5A5|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MVFLLSFVSLSTLAAKPVIALEKELTPVTLSIKQPLTIAINETSFPYHAIDEQGNVIGLM
ADMWRLWAKKQHVDIQFVVLPWLETLSQVAKGSVDIHGGLSIIDSRRDTLDFSASLFHVY
SHLYVHQQLNSVDSLADLKPYSIGVVTGSAHIEKLQKFHPDLALKSYDNRHDLYRAALNN
EILVFTGLEKLADNFPDYERLRQRFPVHKVLRYQQGDYGVAVAKNNASLLRFIEQGFAKI
SRKESAAIERKWLGLDKQKDSLLVVFSSHYPPYMGVSPSGEPQGLLIDVWRLWSKSVGIN
VEFVARDMVEGVDLIAEQKADILLVYPDHMKAPENTLFAKPIYLSNVQVFVNHALKNSEG
KKIHSLEQFSKNFSQGIIGIWQDASFKEQFIAQYPQINIRYFSSLSTMLNAADQGEISAI
VGLVDIINAKLVQSNLQALFYRLDSPVITLNLSPLIHQQNTKLMQIINKGFNELDINSLI
QIEARWLNGNTGEYYYKKQAQKISLHDDELAFLASRGKINLGIIKQLSPIEFIDELGDFA
GINRDIINLISDRTSIEFNYVAFDSWQQLYKALLANEIDMLGSITPIPEREKVLLFTDSY
WQMPWVMVHPQYYGRKNKLEDFYGKQVAIVKGYYIIANLRKNHPLITFKLVDHREQALVA
LQQERIDGFITTMASATHLLKQENIVTLMISMMEDVSIDTSHFAISKQLPLLNDIINKGL
RSITEKEKQIIYDNWFTLAIKTGLDKNVVLQVGAQIGVIILLVLGVIVMWNRRLQVEIKH
REQLEKIMKHMATHDELTGLANRVLLKDRLSTAIAFHQRQSLKMAVLFIDLDGFKNINDT
HGHDVGDELLQQVALRLQGCVRSSDTVVRFGGDEFVLLLTGLHSPNEAAYVAEKVLRLMQ
KEFELSKTEAFIGCSIGIAMYPADGDNDTELLKIADTMMYKVKAAGKNHYIFN
>A0A168DV93|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MGISVILVLISTIIILTSIIYVGTRKSKKQFHYVYMMLVSSVLIWCIGALGEVATEDVYH
FDPFIQTCNYFGIALVSVFILLLGVVFTHTRIVITSRFALLFILPIGSAIAVATNERHHL
FMKVFCIIIKDAVLGPLMWAHYIYCYIFIAIGMSYLIKYAVNNSGLFSKQAMTLVAGMCT
PLAINVLTSFGIISGGCYSTIPGIVIMILLIGIATLKLDMFNIVPIALQKIVDHISDGFI
VIDENRKIIDSNKAAQLWLSDKHEIRRNQDFKEFMDSLKIENLDTSKLLDYIKMSFEKKD
SISFDTLIKFENGICYFNIEVTPMFSKNKYIGTIILYRNTTKYIENLQMIKEYQLLLENN
LEKVTRDKQELLIRSAIMEKMSKTDALTDMYNHRTFQEYFDTIIDQASRADNRFQLALLD
IDNFKKINDTFGHSVGDIILKRISSIIKTMVTVDDISARYGGEEFALILTNKTLEQSLAL
LESIRKAIQDESHIELNSNVTVSVGVHEYYKGEPKEELFNKADEALYKAKHSGKNKIVAS
TVYNLGL
>A0A1Z5I5W8|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MNISKILLIIMLMQLMLASVSLAKEPIIASAITEEPANEKALLPLPAVSLLPINEDLLAI
LTQLKQASIDEQKIARALEQLTLATTPLNAAEQYLLLVTQALFKENAIANGVEHSSHNKQ
SREIIVLLEQALKLSAQISAQQLHQPNFLQLHLILAVHYAQQGQFDLAYLEKKSYLKKYY
SYRKAKRLAMIASLEQSFTVHDKKASNSLLASQNKLKIRRVAEVQEQKATQQYNFTLIIS
TAIVFVLLFFRQLKIRNKLIRLTRTDALTGLANRSALFEHGEHMVASFIEQPEELSILLL
DLDHFKKINDDFGEQVGDEILRVIAQLVKETMRSRDVFYRLGGEEFVAILPFADSNKAKA
IAMRINEKIAQHDFSLLILQSRVTVSIGVATMASNKLTFEQVLHCADLAMYQAKELGRNS
VVCYQNIAQAQERRGNTNSVK
>A0A143QAZ1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MATISTSWVDRLRSVLGEHDDATGVSFDRSGPNTLTRVVVGIGTIVIGVIGLLSAPSEEY
SGWGAVATAIISLTSLPVGVWVCFTRRFRGRVVVAFVAWADVSVTVCMLLKEERLTAIGG
TALFAVLTTLAVIATPLAACLTHMLYSTVILAVIAVNAVLWQAASLWVIAAHTLTMLLVF
LTPFVLLVHLGELRGQARQSLLDPLTGLLNRRGLEDALLRLAHRVDGDTTLLETVVVDVD
DFKSVNDRWGHHVGDTVLTDLARHLTVVTAGRWVVARLGGDEFACTRVTDGPGAADELAA
SLTRVSMVAGYTMSAGAADVPLPDRSPAAVTEAMTAALRAADKRLYDSKSRKARGADDHA
RGHRGRRGDDANATG
>A0A5Y3N3M1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETSRSGFY
LSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTVSLP
LDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTANTLN
DRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISIALT
LLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRY
RESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A8G0EDM2|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia sp. DSM 110487|TrEMBL
MSAEPGARPGGRGPSAGVRRWVAGWDLWEVPRRLVAPVFTVELTALALMVFGVLTTVPES
REIRTAVLICVLGVVHTEIARDVERMRRRITGEELHVDLGSVWFFMAAILLSPGYAAVVT
VLVHSHIWYRAAYRRAPLYRQVFNSATMMISAFAASSLMSYVFAQQRIDLLDSRALLVLC
FGMLAFLTINSALVAGAIAVSTPHARLSQMVGVWSENLLEIATLSLGALVAMAYLTNPWL
ALFCLPPLLVLHRAVLVRQLEEAASLDGKTGLLNAAAWHVQAERALQRTKRRDGPPGVLV
LDLDHFKAVNDTHGHLAGDHVLTAVADVLRDEVRERDLVGRFGGEEFVVMLAGLGGRGSA
EIEAVAERIRRRVADLRVEIPTPDGPLTVRGLSVSVGCAVMPDGGAELRDLLEVADRALY
AAKGAGRNAVRMGNATSTRPALLPVNARPNPPTAVEPPTLHSNAGD
>A0A4Y1N0R4|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MRVERGRVHGSLRPPPPPMPPKRVTRRDMFLDAPTLILAVTLVTGTSALACLMSWRASPG
HDLPLIFGGAFLS
>A0A378Z8F3|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MTIQRPPTPTLPPGTGAPMAGLLSPLASEARTGAPGAAGDPPSAAVNGASRRNDHLPPFD
NQPAMASTRGPRRRARPSLQRVLRRTHLRLAVSAVVLAAVSLTLVAWIGLRAYAENNLML
LGRSLAYTAEAAVVFGDRVAAQEGIALIANDEDVVQVRVLDANGAQFALWRRPDGGTLTR
LERTVADIALPGPVTLPIRHDGNVVGHIEVQGQGHQFFVFLLSGVGGVLACLLVTFAVAN
VLAKRMHRDIVKPLRALAEVAHAVRRERAFHQRVAPTPLAELKELGDDFNALLDEFEGWQ
NHLRAQNATLAHQANHDPLTGLPNRGYFESRLAQALIDAHELGTHVALLYLDSDRFKEIN
DQMGHDAGDAVLITIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRLAQSLLVA
MEKPIPLPDGGEVITSMSIGVALYPNHAADAPGLLRMADAAMYQAKRAGVGTWHVAQSLA
>A0A1B7I5L7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella gaviniae ATCC 51604|TrEMBL
MLGNALQRVIGRFKNPQKVVNLCFIFVFLFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHSIDNLLFYRNAMLYALQSPISTDRTRKSLADFDTLRTQPFWQLRLDLSRSLPM
SGVSDEFVNKSPLLDRDEHTLHSELSSALELSYIMRLSDSSGKMPQRMFYASRSGFFLTN
TPPANDPNIVSLYYRLIARPYFSSQSLQNNPQRSLKWTHTFNGNDTSGQIVTASVPLDFN
GRWYGVLALDYPIESLHNFLREAKYDDHEGTVLLYDNELNPIATSARSLPQHELFTAPQL
ARIANVVTAAKQGEQGELRMDSRFITWAKLNNFDGLLVKVHTLEEGVQGEFGRISIVLSI
LWMLFTLMLFASWMVIRRLVNNMFSLQQTLTWRANYDTLTRLYNRGAFFEIARKLSQECE
QQGLPFSVIQMDLDLFKSINDRFGHSCGDKVLIHAAAMLSDAFRTGDIAGRVGGEEFCIV
LPETTLEEATKVAERIRVRINTKELLIKQGNTVRISASFGVSSSFEFSDYDFERLQTYAD
HRLYKAKQGGRNQVCNHD
>A0A011MZT1|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MTADTMPVDDVVGNALVPISGLLRLLLPTSAVGFAIKGLDGRYRLANPTIEELLCRPGEH
LAGRSEDELVPPPTCSLLAECDRQILAGETSASAWVELGHSGQRRHCAWLKMAILAPDRT
LQAIASLVEPAIPQQASAAIQETLRRLQDANRDLQQMVVELEQVASTDRLTGAWNRRRIE
EGVQSEMERMVRYGHPLCLLLIDVDHFKPINDQHGHAVGDAVLQRLVALLQAALRKVDSL
GRWGGEEFLVLCPNTARATAAAAAERLRQEVADAHFATVGRVSVSIGVAECAAGESWQEW
FARADAALYRAKNGGRNQVQVAPEVACHANGKDYVAADFVQLVWRSAYECGNEIVDHGHR
QLFADANRLLSAILADQPADEIGTIVDRLLSDVVAHFREEEAVFTAAGFPAAGEHVLLHQ
ALTAEAHRLLDHYRGGTRAAGDVFQFLAYEVVTKHLLGADRLFFDFLRPPATAMNPGSEV
GPLASPDARR
>A0A4Y1N154|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MALQFDRSALPLLVTVDLSNALAILCSALIWAGHRRADGRATPVLLILLAPLVWLLACRI
PEFYGRYDRRVLLASLLHGGLFAVAAWELWRGRAERISARWWMFAAMVGSVAVMAFRGVA
MLVSPDPVRFHFLPDLSLGLVLVSALVFFVLHGFGAVTMIRERAEAHYRREACSDPLTGL
PNRRRFDQAYAHEFARARHHGRPLSVLMIDADHFKAINDHHGHPEGDACLRRVANVLQRN
LRDGSDLAARLGGEEFAVLLPGTGLEAAMGVAERIRRSMRAQGIPHPTARGGMATLSLGV
AAMAPGQEISPRGLLEAADRALYAAKREGRDLVRAQAPDSREARPASRLRSRPDLPLTQC
>A0A554WSF5|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MPQSRMLEHLEHVARLTHGRDREGLDSTLTEVLSSVLQAEAVTLWEALPHETGERALRRA
VAGAAAPADAVVADEPPPLSAVPGLAAVLQTGRPEVLEAAGGQRLLVPLQTETQRRLVLD
IVLSRAVEAQDQRVAEGMGRIYVNVINLLEASERDTLTGLLNRKSFDDTFYKATRPADAD
GAPAAGGERRARAATCWLGVIDVDHFKSVNDRFGHLIGDEVLLLMARLLRQTFRHDDHLY
RFGGEEFVALIRADDAAAAAAAFERLRASVEAYPFPQVGRITVSTGYTAVRPFDTPADAF
ERADRAVYLAKAQGRNAVRCFETDVAAQAAAEPMQHAGGGVELF
>A0A3N6CH82|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI91-18|TrEMBL
MDSVLHTTGRFGPRTLLITAAAVPLTGWAVHAATLYKQIAAKEKDPLTGLLRRDAYTARA
RRLLARHGDKVTVVMVDADHFKQINDGMGHEAGDTVLASIGARLTAWAGPRASVGRLGGD
EFAVVLELKDDRRTQRLEQLVRMLHTPVTLDDGRTVDVAASVGAAAPASVGSRDLTRLQR
AADAALYDGKHSGRAVLATRQHVTVPSINGRRAGRPGTAVWGRAA
>A0A8J8AL55|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MTAENISSDNVSMPPAKEEYLDAVERHICQVLGFDYGFIDIVSGHDIENVVSFTAATHDE
QVDKLVHELIDENKQPLAVANTLVAQKVKSTQRPWIGKAYIKNKGQDDNELPYAIIPVMS
DASDRQGVVKGLIRVVCFDSSREINNQDLSTLRLMGEHLANRTQLFFNAVVEPQKAGSAP
TRKEGEVEQQQIMMLHSNRVIRRRFSRILSDRYKLFECDSEEKSLSILSESRIDLIIVDS
NLNGTSGFGFCKMLKESQEWKHIPILIVTPDSNPAARVEALTVGADDCLSDSCFDSELVA
RVQSSMRHRKIEKELAFQLGLLEDYSQQLEKAHEQMSQDRQSQLQRNTLLEQLRRESDIL
RHQESLLHRISNTIRRSFTIKENLSEMLEELAGWFALDCCFLVLPSEEEPEDTIRIEYIT
DDIYRVVAFDRDLATLDLYSKLFAADQAIIANDVANDRRLDAFRSQVLSGYNILSLFYIP
IHYSEKLQGLLVGFKGEVQANWNRANEAFMKSVADQVASGVTNARLYARVQRQATTDGLT
SLYNHRTGQEKLTEQLRMAERYERHLSVLMVDVDHFKQINDNYGHPVGDTVLKAVAKLIK
GNCRDVDIPIRYGGEEFMVVLPEVSRDGALVVAERIRKSLAQEVIKHDNFNLSVTASLGI
ATFPLDAAEQHILLEKADKSLYLSKRMGRNQVHSADELEFDQSRGAPKAVDNFGFDVDKI
SEEGRNGEELTGEVVEMVKALAQNLYARSDYNKAHHLEVSRLSELLGKVMGLSKNQIEQI
RVAGLLHDVGTLKLPEDLMKKAGAYTDEERRVVNQHPVLGAELLRPVKALRDICEILENH
HEKWDGTGFPRGLKGEGIPLPARIVSIVDGYHAMISDRPYRPAMSREEAIRNLRLGAGKQ
WDPFLVDIFIAVLANS
>A0A8J7V5X5|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MAIKVLKTPKLSIRARMFLLCLGVAMPLLAIGSFSLFKEYRTLKLEAQRATTLQAATGVR
TLGNWISGQLTSIDQVANLLERQNLSTSNEEIQKTLSTAIVSQPAWQKLILVDSAGKRQF
AAVQSGKSADNKIVTSDLAIKQLLERTRASKKPVMANATLIEGKKCYLVAAAPLTSGDKV
RGQLLAFIDPSAVLNLYAGLSATDKSSAVIAVIDADKRVIARTIDNKEWQGKDFSQAHTV
QAAANQVRGTLEGVGIADPTPRAYAFDHEPNTNWLLVVGLPTRLIYGTAHDWLILMICLA
ACAISVSIMLAYSSTSYFTRAINSLVREALSLGRGDFGKRVQVRSNDELGLLARAFNEMA
SMLEVDRDHKHMVQRISESIRQSLDLNEILNTTVKELGQNLNASRCCLALIDSHQTSDQD
DDELSFDYMWCNPDDQTAPLTKKKILIGVDTTMRKIINQGSIIWLDLLSQGALFDGHEES
EWRLIKSMIACPITTGNGTIGLILIHQCDHLRSWSQSELELVNAVASQVALAIEHGQLYN
RARTMAEQEQLINQIVRAVRTSLDVDTILDTVTKELSLALSADRVQIAQPRAEGPLVVTH
EYHREELESSKGLSLYGSAIDFHPNAKSPQLQTDTGNYVLGIDLSRIRKAFKPTLNNLSN
KPEVENLTPEASDVAATTGDLPQELVSVVNGTHGDARCLVFREYLDVVGGKSLIAAPLIN
DNQLIGVLIVHQCSEQRLWRENEAKLVGAIADQISVAIAHAQLFAQVRHQAITDGLTGLY
NHVYFKNRLSEELRMAERKGTPVSLIMIDLDKLKVINDTYGHPVGDSAIRQISSILKTLL
RSGDTAARYGGEEFGIILPETSLLEAALIADRLCSQIRNCQVPVLGKITASLGTASYPKQ
ARSTSELIERADKALYVAKNSGRDQVRVYEDDMDMNALNQPTFTNVTREMDRPKTIPPNP
NEKGS
>A0A1J6Y6X9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 50:g,z51:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A6N3AKW1|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MTVLQQRSDALLLFPLPLRSRGVYCPDTNRAILTTWILKGWRLVVKALKIEIFLLCMIVL
IGLAARSRHSLFSSTQQLLFSTLGYTSAAYMLFDIIWTLSDGVGGTLGIAANWISNAVSF
SLFAAACLIWFIYSETVQGSRLLTARYRMAFVTLPAVLVVVLAFTSYWTHALFYIDAQGA
YRRGFVYMIQPIVSYCYVIYTSLHAFIQSCKVESLQKKAIYQTLAFFAIPALVAGVFQVF
YSGPCLSVGIMLSMLQLYIVCQEQLISTDPLTGLNNRNRFETYMLSLFSGADQADDVYLL
MMDADGFKLINDRYGHVEGDHALQVISATLKEVCSASGGFIARYGGDEFVVLQKAAAEQD
IIDLCSAINDELARAEVPYALRMSIGYARVGDGVDTWQDLLRAADAELYRVKAEKKKAGV
QIR
>A0A143X659|diguanylate cyclase|EC 2.7.7.65|Clostridiales bacterium CHKCI006|TrEMBL
MDHLAKTTFDSFLSAFFVERNITKALSFVLEDVLFLGTEIHEIALNKEEMLPYLEKAMQR
YQHSFSYQKLSDCVLSFASPNNCHISGLIECTQIASLSTYQVRIVADLVKTTTWQIAYLH
FTGPVALQASPELETHPMSETQTNPSLISLAFNLFPCGIMGNYMNEDYRFYMINEEMLAY
LGYEDYADFIQATSGQLANVISVQDRDRVFQSLREQLCELDEFEVRCRLVRKDQTAFWAY
IKGRKVVIRENQQALVSVAIDVSDFISIQEVLQKEASEDDLTGIYNRRQAILMIENSFRH
YDRGALCILDVDNFKSVNDQYGHQEGDSLLIGIANLLKKHVRQNDVIARLGGDEFLIYFI
GMTERATVEKRVHEFQREFESLVKDCYEDLNLSISAGIGMREHYENFDQLYQMADMALYE
TKRNKKRNTNSILFGRRSF
>A0A853P0G1|diguanylate cyclase|EC 2.7.7.65|[Arcobacter] porcinus|TrEMBL
MEYLWLNPKTNKLEEKISFVKQIPETNYILGSGFYISDIEKQAKINDVKNLKTYEKNIYI
TLMIAFIFIILAIIIAFIISNILLRKFNFLINQKNNLEKESLVDSLTNLNNKVCFFKKLD
NYLNNIDVEIFSLIIFDIDDFKNINRDFSYEIGDNILKELAILTKNSLPNNVEIFRVGGD
RFAIILPNTDLNESYILAKRLKNNCEGKLFEKVERITISLGIIEALEESSSNEVLRKIEL
ALFKAKKDGKNRVIAYKN
>A0A1C5P489|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MWMKLKCLLGIDAGLRDFDEIECSLHRDVVNRNFFFHLFIIIYELVMLVSISLRPGGPFL
KPRRTAYFLMYLILILVTLCVMAGQAWVDRKKENSHRYYFWIEHAYLVFFSFWGIAVTLN
DQLGGNGLTVYNYVILILAILSMMKPWKTALLFLADVLVFNLLLPYFPDPAGLNHTYNNL
MNSLFLSLVAIGIATSLYNSRIQSKKDEITIRRQYQQIEAANKILSKEALTDALTGIQNR
NSYKKAIRTLTQPDTLSLACVYIDVNGLHEINNHLGHKAGDVMLKTVAAILLKNFGRESV
FRIGGDEFVVLCRDVLHQTVTENLEDVRQAVERAGYSISVGLEWREEGLDINEIIQAAET
DMQMRKEEYYSAQGGERQQRSLDSQMERVITEKRDAERFLRVLAPVFKGVYFVNLETDTL
RRIFIPSYFEKMLEESRDSFSKALLMYANRMVEPEYVRLFEQFCDYGNLEMMLDGDEIPG
FIYQKRDGSRLKLRVLRCNSYFSSSQETLWIFSDMEESY
>A0A1C5VQL5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIYELSDLTRTIMNLGFSLIGIYFAHTFQKSKRKLWQCICTWLLVYLFWITAGAFLDACF
LNHSAFPNMTHERIGMFIAPLAIFAYRFLYPEARLPACIFYYYMADNVLILQILFSRTLA
MLLVQLFGLPDQETILCVYVLSLAVVVVLYRTWARGKMRCVLRDFQDRMGLLAAFAFVSY
YGSLLLVDAWAPWQPLTGVNAARNFAAIIIPACGYGVSFLGAEEHVRAEEMRKKASMDPL
TGLKNRRAMLNDIQEMLETLSDPLWLVCLDLDNFKSINDQYGHDIGDQYLRRFGTMLEEM
TEQNGQAYRTGGDEFAVLYSGGPAEKIEALRECYLQSFRDGEKPEFLGVSIGYEQVQDFE
SLAEVMKRADEMMYVEKRAKQYARGYAAEDTKEVLTK
>A0A7U5VDU3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp. FDA-CDC-AR_0132|TrEMBL
MQRETFVVRRSFLQWLHMRSNPGLIVNLCFLIVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRKSMRDAIQTPLAFDVLYEAISRFNAFRTRPSWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDPERISNEISAALEVGYLLRLASSVGQSEERVIYASRA
GFYLATDTPEQTSDISQRYYYLVTQPWFTQQSERNNRARAVRWFISSPSPWTGGERMITA
SVPIYFDHYWYGVVAMDFSLKTMKHLLEEATQERTEGEYQLYDTRLNMIATSEETGSLVN
RFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKMLS
ERCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIGSALRKNDVAGRVGGEE
FCVVLPGSGLEEARGIAERIRSRINSKEILVKKSTTVRISASLGVSSAQEKDNYDFEQLQ
SVADARLYQAKQCGRNRVFWHDQDKK
>A0A1C5VMP4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSVKNNILLRTNIFVCTIIILGFAVTSITSYRANIGVFEKDVEDVTDLASEGIYYKIDSI
FTKPVNVSLTMANDSLLKEFLAEEQSRMEDETFIKSMRDYLYAYREKYAYDSVFLVSAQT
GRYYHFNGLDRVLEQGNPENTWYYDFIADPHEYSLNIDNDEAGDNEITIFINCKIKDRDG
TVMGVVGVGFRVDYLQELLKSYEDEFNVRARLADENGVVEISTHHTSYEPVNLFDDGSYD
DMRDQLLSGREEMQTFWHTADRSRGYMVSRYIENLDWYLLVENDTTDLNRHMKESLEQGI
AVILMIVAGVLFTITTVIRRYNAQIIELTTAREREYNKIRQDAAKELYENIYELDITHNC
AVGENTERYFESLGVPVKTPYSEALNIIADKQIKEEYRRGYVDTFSPEHVMEAYSQGVKS
LTYDFMITNNGSDYYWMRIMACIYFWSEDNSVRMTIYRQNIDEVKRQETKLFEQMQSDPL
TGLYNKAATEEMISEQVKGAEPGSSYAFLILDIDNFKHVNDTLGHSAGDFVISQFAQNIQ
SHFREGDIVGRIGGDEFAVFIPFTGMESLEKKVQQLVADLHTCITTEAGKCNVSASVGIA
IYPGSGMDFETLYKNADLALYKTKKREKNGYTVFKK
>A0A1C6DTJ8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNLGFSLIGIYFAHTFQKSKRKLWQCICTWLLVYLFWITAGAFLDACFLNHSAFPNMTHE
RIGMFIAPLAIFAYRFLYPEARLTACIFYYYMADNVLILQILFSRTLAMLLVQLFGLPDQ
ETILCVYVLSLAVVVVLYRTWARGKMRCVLRDFQDRMGLLAAFAFVSYYGSLLLVDAWAP
WQPLTGVNAARNFAAIIIPACGYGVSFLGAEEHVRAEEMRKKASMDPLTGLKNRRAMLND
IQEMLETLSEPLWLVCLDLDNFKSINDQYGHDIGDQYLQRFGTMLEEMTEQNGQAYRTGG
DEFAVLYSGGPAEKIEALRECYLQSFRDGEKPEFLGVSIGYEQVQDFESLAEVMKRADEM
MYVEKREKQYARGYAAEDTKEVLTK
>A0A1C5U5C4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKKIALLQGGFNGEVMKYAIRGIRKRIQEEGADLYIFSCYGGEKEDLLYNQGEYQIFSL
LDCNEYDGFLMASNNITSGEEREKLRKKLVASGKPAVSMEHELEGLYYVGCENYRTVKEI
TLHMIEKHGCRKIYFIGGPEDNYESQKRKKGVQDAMDLKGLQYEEAWFRNYNYTYHDGYQ
AFYDFQKMGLGVPDCVIAANDEMAIGYCTAAGEQKLYAPEDFRISGFDDLRIASTYRPSL
TSVERRKTETGYQSCDVLFRLINGEDVPKKTTLKGEVVYRSSCGCTSHEEKHQNGKRHII
ETMLNRNYVQNNFQILQKRLVQSENWNEYANTLAEHVINNIPCSAMYILLNRTEQLEQHT
GQILNNQEYDSKLIVIFALEKGKLVEYKELFDISKLIPGEEEDDEKSHAYMIMPVHFQEK
TIGYCVLKDSFQMIDDESLFSGSHCINMSMQVMIERLALKQMNRMLDELSAEDAMTGVYN
RFALSRHAEKILQYDRLEQRETLILFSDINRLKMINDTYGHKNGDIAITTVANVLKKVCP
KQSVVVRYGGDEFVIVVSGGDYNKGISIKQAIHEELKQANEILDIPFQISTSVGWVCAKP
DEKLLLEEYVKQADKVMYQEKKKTR
>A0A1C5Z6Y5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGKLKKFIMNKIEKVNVQVSMLTCGLIIFSCLVIYLVTSGVMISMLADAYNERANLTFTT
IESHFDSRLFTEDVPDGVYGAALSYLSAVKDNMAISEIFVVRKDKNGDFQYILDTKNDKI
NTVINDEKITGKIEKEINDLYTTHYADVGAFYASLDGFRYLNFYPIMDGGTVKGVACIGI
DANRVYIFKIILRVIVIILILLCCLISVRFSMAIFKRISNPLYQDMSNTDTLTGLKNKNS
FTVDMHNIESGNQSRYAIVTVDLNGLKNINDSRGHQMGDIYIQNGADAIRKAMEGTDFIG
YRVGGDEFSVVLKDCDIDMVKNFADRIARMADSINRGGIKTSMSIGYAKFNAEKDRNFSM
TMERADAMMYENKRLYYKTKNLKRREE
>A0A1S8TR67|diguanylate cyclase|EC 2.7.7.65|Clostridium puniceum|TrEMBL
MRNVNNKYLIEYEITMEENFSNYLVTDPEKNEKYVLCILKNDFTYEKTREYLLSKFKTIK
NFNFDYLTNIIKIEIIYSINGIKLSKPQYGYLMEYVETKIDTKKYLEKCTPYKKLDIFME
LCAAINTLNIQGYVFDDILIKDIKLIPTSRNDVKIKIKNLLQNELSKFNLLNSAINLLPY
QYNIETGEEGNLNRDNIEQIIKLFNQIFTDEDLENELKELNYIKKVYNQVKTINNSFKLH
SFIKDINDKMHTDYKYFTSSALNKLQTDLDIIGMEEEIKIVEKNFQKILESKESYKIIGF
NGEDGSGKTRLLEELRYRIENKYFEDILYVTDFIDKNISKEDRYEKVINFVLEKVDKNLK
DKYEIYIKKFVSILIKENPSRSDNKQKLQLINRIGKFVNEYTMSKPFVILIDDLHQRSEV
FKLFIKYIAFLGHKLENVMIIFSANEEKYDKNFLNFIKELKELEQYEEYKINYFNQYNTT
QMIKRMLNTNEEISKLSLRIYSETLGNPQYISGVIKELYENKGLYFNEDIGRWESDIDGK
DILIPKILEKRLELNITTLNEDEIDILKRLSIFETPLSEKIILKYIITELKERRIYLSLK
SKGFLEDKISDQGILVGFTNNLLRNILYLKLKDKNKIELHFKASVFLEEVLFETDYYIEE
FLIHLERGKNYKKACFYTLKYSKVQELLGNLSKSIKYYKKALNYADNPNICNIAINIAKL
YEKKSKHEKSYEYYEKANQLAIQDDELEIEIYTLLEMIIIKINDITDMNTGIDYSLGCVR
RLLDRVNYPKGEVFYYYALALKYRLEYNHKLTLINAEKALNICDENKIKEDVYGWLNMTI
VNVKVKRGDYEEARRLCLNAKDIFINNNNINGELSSKLYYASICKEEGHSNETILEQYLE
ITKLSNRNKVYKKEILSLIYVSKIYSQQKKYKEAEEYLLRALEREREEGLEVYSFKICNQ
LCLLYIKLGKINLAIKYYYLTKQMQKVIKLLEEEVIDSNYTYALYNLLICNYNVAYDYLK
KIYTLNLNTKNSYHKIIICNYYEVMLYKCKNEDDIKRVYEKLNCKFEGVKNTELELEIRI
NAIKRILLLGYKNFARKLFLKLKGYPKDYNIEGIYVYLEFNFRGKNYYNFLINKALRICA
YMNNQELKADIFSMIGQKYTELNCYALAMNYYYESIALHIDIINLLPIDDQLTYINNSSF
LKTREQFLICLNSDLNINVEFKKYKNIKMNKELDELFEELNIKNILDNEAIFNLIQNLYE
DCYYNDLSDIYKVFERFSSDTISNLENVMKYMARLTLADKAMIVMENNEGENDVICTYRI
SDKNEINRYFSLKVDSDEDIFVISNNDEKFYQLDDKVLKDGIKACMYMRIINREKQINSS
GGINARLILITNNALNYINSESKKMVEKLKPFLTFLLEKYNLTISSTLDKLTGVYNRKHF
EEALLFLLDSARLEKTEFAVIMFDVDDFKGVNDRYGHQTGDEVLIKLTKEVNKCISKSDI
IGRYGGEEFILLLPNVNKEKAISLAEKIRVNVEEAKILGDKRKVTISIGVAMSAYEFLNS
QEIIERADQALYKAKNEGKNRYVLWEKYYGISTNTNNELTGVLSGNATKDYNLAVILKDV
ANIVKYKGSKEDKIYEFILKVMQIIECKTATAFIVKQKKIINMYSKSRAKDGWYVVEKFN
FKLIYETIEEEKGRYLIDWDSMDNYNHYGIPDWKSVCMTPIICNGEILAVLYLSVSVNKR
EFTLNEYNLLNCFAEISVPIFDGI
>A0A8H9DK99|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A3P6L2U1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQVDLDHFKAINDR
FSHQAGDRVLSHAAGLISSFLACAGRCRRVGGEEFCVILPGASLTEAAEVAERIRLKLNE
KEMLIAKSTTIRISASWG
>A0A3R0XHS0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFLHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGH
SKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSI
SGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X2KQD3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSVKLRLPHCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFT
VSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3R0XJ22|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MAMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAKVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1A7C602|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium psychrotolerans|TrEMBL
MPEFSTRFLPPDTALTEFKVSVLLVDDQLIIAEAIRRMTSDQLDIEFHYVTDAELALETA
VRMQPTVILQDLVLPGTDGFALIKQYREHEALAHVPVIVLSAKDDPKLKAYSFAVGANDY
VVKLPDRLELLARIRYHSNAHISRLQRDQAFRFLRESQKNLAEANIELQKLAALDGLTGI
ANRRRFDETLQIEWQRGQRDKAPLSLLFCDIDLFKSYNDQYGHLAGDLCLKKVAAVLTEH
LKRPADLAARYGGEEFALVLPETCVEGAMKIAEACRRHLESLQIEHPVAALGIVTMSIGV
ATVVPSPQSTVEQLINHADQALYAVKRSGRNGVLKAEDITT
>A0A378GTK6|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRNISFCGHAILQEGPFIVHDAAADERFRDNPLVTGEPHIRFYAGQPVNL
PDGTVAGTLCLIHTVPRAFTDDDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKVFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTSSFLQALSASLDHYNDTSGKPYNINYSFGELINNADQYATLAE
MIGKCDEVMYLKKKRKTLSRKAEP
>A0A379JBC4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPLQAVRPKILGFISEQASAWLVALVVLLVGVALTAVLALTTADRHHQQVRQRFQLLVNE
RYSRLEERFEDQEQRLGSLQRFFVNSHDVSREDFDGFAQPLLLRARAYAWAPRVARDERR
AFEQQVSRQRGAPFSIRELNEAGALVPAQERDEYVPVLYSQTQSILGSPLGFDLLAQPLR
RSTIERAYRSATIAVSQPMSLVGVEPAYTMGVLLVAPVTRPPTAQMPYNEPYGFVMAVIS
MRQLVADGLPKPARDNLVMQIVDTSDTQQQLLYESDNPVGDSSLESIRRLTLGDHVYALS
LRPSQVFVQANHSSTSSILAMGSLLSLLLSALLYVLVSQRQRALRLVQQRTGQLHQREYE
LRGAHGQLRSVLNAATQVAIIATDLRGVISTFNAGAEKMLGYQADQVLGHMTLESLHLAP
ELEARAVQLSLALGKRIMPGQAMLVEGSDSLHEAREWTLVRQDGSQLTVNMLATALLDEH
GLWIGHLAICLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPNDNWRFIYASDG
IRDIYEIDPGLLQQDAKQVFERIHPQDAERIRASIRLSALQLSQWREEYRVQLPGRGLRW
IRGEATPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLRAEM
SRVRRTSGSLAVIMLDIDHFKRINDQHGHAAGDGVLQELCRRISLRLRRSDVFCRLGGEE
FMVLCPNTDGVQAYSLAVELWEVLRSTPMDGVGTVTASFGVASWRVNEGVDGLLLRADSA
VYAAKQAGRDRVEAQRLPV
>A0A3S4PEE2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLARDSLVQAGLPDNPYARQLRNGFRWLRFEKELENEFREFLSWNSLMQRRAAIGVAFLI
WALFIVADWMMVDIRLHPSLFEQLLGVRLGMIGLLLVVWPAAFLPSLRKVGDAIAPYCLL
LINLAVLACDVLFEWHGVPRFTQLGATLGILAVFFPLGLAFWACVRLALLCLALNLAVFL
LFGGEENLRTNLLNTLYNGLVVLICSFALYLQDYAQREQFLGRRLLGMMAEQDSLTGLVN
RRYYELLAQRALEQGAREEKGVALILVDVDDFKAYNDHYGHPAGDAALRQLGVVLRQGAR
RPLDIAARLGGEEFAVLLYDSEEGNTLAIAERLRQAVEALGIEHLGSSAGPCLTISLGVA
YSTSGMGLDALYREADRALYEAKDAGRNAVRVAFRQHDRLE
>A0A5E6TC09|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTEGKGLSLARRLYTSRILGLALGLLCVGAAVYPLNPAPWVWVLMLLNGVLWPHVAYQ
WARRAKVPFHAEHRNILMDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQVLGIGIGWLIFTPLFIPQTTPLQLYACLPLLSLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDRLDVEFQRCQRQHQGGAVALIDIDHFKTINDTYGHVAGDI
VLRQLSKILKQNLRAADLCGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFNPTHPDSTFWLNDADQALYEAKTTGRNRVICCGDGRARHAFLDAV
>A0A5E7IPM0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTRGKGLSLARRLYRSRVFGLLLGLMCVSVAMHALDPPLWVWGLMLFNGLVWPHLAFQ
WARSSSVPFRAEHRNLLIDAFMGGFWVAAMQFNPLPSATTISMMAMNNVAIGGGRFLLAG
TAAQLFGMGVGLVVFAPAFIPPTSPLQLYACLPLLLLYPLALGWICFRQASTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLNLAFQRCKRQQQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFAVMGYEQNPA
LKVSLSIGLAAYDPSHADATRWLDEADQALYEAKASGRNRVICNSDNKPRQALLDSV
>A0A109LEW8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MFSVLKPHRWKLALLLIAANLGLILHLACGELKSVSEWVWLDIIGEGGSALLALIWLGLV
LKSRPAGRVTQYLALGLSCIFFSWWIDSLDEFIRLPDSISWDHWLESGPMPLGMILLTIG
IYHWHHEQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLADSLRDSQAQQQPLSL
LALDLDNFATINQAYGHAEGDAVLQAVSHVLLLNLRRQDLLCRLAGDRFVVLLPNTGERQ
AQGLALELQHAVQSLAHKTRQQGERLQLTATTAVVMALQESPHELLKRLNMGLARAKQPL
AKSA
>A0A5E7HH41|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLIPGKPVKRGACTDPLRSPLQERELLRDLARKAEQELMGVQMASMDELTLLPNRHGFTA
LAQQGMDACQQLGLPATLLFFDLDNFKRINYLYGRAEGDHALKTFADVLRIAFRESDVIG
RLGNDEFVALLTGASVVELSAIKARLEEILAERNATANRSFAIHFSIGQVEFDARLNPTA
EDVLTLADKAMHDTDHC
>A0A0B7DDX0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGRKGLSLARRLYTSRVLGLVLGLLCVSVSMYSLDPPLWVWALMLFNGLVWPHLAYQ
LARRARVPFHAEHRNLLIDAFFGGFWVAAMHFNPLPAATTISMMAMNNVAIGGLRFLLAG
SAAQLLGVGVGLVVFAPAFIPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGVHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCIRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFATLGYEQNPA
LKVSLSIGLAAYDPAHPDATRWLSDADQALYEAKASGRNRVICNCDSLPKQPLLGLGVR
>A0A5E6V935|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAKAGGKGSSLARRLYTSRILGLALGLVCVSAAMYPLDPAPWVWGFMWFNGLVWPHLAYQ
WARRAKTPYHAEHRNLLIDAFLGGFWIAAMQFNPLPSATTISMMAMNNVAIGGSRFLLAG
TAAQILGVGVGLLIFSPAFIPATSAVQLYACLPLLCLYPLALGWICFRQAHTLGCQKREL
LALSRTDSLTGLLNHGTWKDQLEIEFQRCNSQQKGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRTTDVAGRYGGDEFCVILPDLPLNRAAAIMDALRARFAILGYEQNPA
LKVSLSIGLASFNPAHADAMLWLNDADHALYEAKTTGRNRVICCGNGKPHRELLDSV
>A0A5E7HPI0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDQILSLLSDTIPKAQTLEQLTRPLLTLLSQITGMESTYLTTIDTDEGVQRVEFARNVGE
MVIPEGLVVPWADTLCKRALDENRMYSDNVAECWGDSEAAAALGIRTYVSAPIRSQNGQV
LGTVCAASSAQVTRAPEVEPLLKLLSGLLGYALERGLLVERLQAANAELTKLALTDPLTG
LSNRRAILNDAARLFALAQREKKYVLIGVIDLDGFKFINDTRGHLAGDELLRGLATQLQH
GLRTSDIIGRTGGDEFIVIALGTPSEHSDLAKDMQHAANLLQDRLSKATIGRYELGHGLG
DLQYTGASVGVVAVTPGSMTVDEATKLADREMYRVKQQRNAQRLQ
>A0A0D0T0U2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAVGGNGLPLASRLYKSRLLGLTLGFICVAFGMYPLSPSVWVWAWMLINGFVWPHVAFQ
ISLRAAHTLRSERRSLLFDSFCGGFWVGAMHFNPLPSVTTLSMMSMNNVAIGGPRFMFAG
WVAQALGLGTALLIFAPAFIAVTTQAQVYACLPILMLYPMALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLDIEFQRCRRGPAGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRTTDLAGRYGGDEFCVILPDMPLNRATEVMEALRDRFNALAYAQDPA
LRVSLSIGLALYQPAHADAISWLNDADQALYEAKSSGRNRVSAGQGSWLRSV
>A0A5E6XJ54|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRQGKGLSFARRIYKPRIIGTAMCCISVIAALYPLAMPGWVWALLLVNAFAWPHLAYQ
LATRSKFPYDAEQRNLMYDALSSGFWVATLQFTPLTTVTLLSMVAMNNVAAGGKRLLIRG
AGAQLLGAGTGALLFGVQFNPSVSLVQVYACLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRIDSLTGLLNHGSWKDLLHLKFHKCQQQQSHATIALIDIDHFKQINDTHGHIVGDA
VLRQLSLELRRSLRENDLAGRYGGDEFCVILPKMPLEKAAEVMERIRETFSNYRNPQIPE
LRVSLSIGLAGFQPSFTDAAMWLNAADRALYTAKDTGRNRVNVSDERVAYSA
>A0A5E7DGH0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSGAKVRPTLRSVIGRGHLILALLAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVAQAEVLDANGKLLAQWIRPDTGLLSRVELELAHTL
LEQPISQPILHQGRTIGSIHLIGHGGSLLRFLLSGLAGIFICTALSAWIALHLARRLLRG
ITGPLQSLAAVAHAARSERDFDRRVPPAKIAELDSLGSDFNALLGEMEAWQSHLQSENES
LAHQANHDSLTGLPNRAFFEGRLIRALRSAAKAKEQVAVLYLDSDRFKEINDSFGHAAGD
AVLVAVAERVRAQLREDDLVARLGGDEFAILLAPLHKVEDAERIADKIIASMDLPISVPG
NTQVLTSLSIGIAIYPDHGATPGTLLNAADAAMYQAKRLSSGGQQTAESENPVVNVKHRS
>A0A5E6YXA8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAAGGKGLPLAIRLYKSRTLGLTLGLVCVVFGMYPLHPSPWVWAWMLINAFVWPHLAFQ
LSLRTANTLRTERGNLLFDSFCGGFWVGAMHFNPLPSVTTLSMMTMNNVALGGPRLMLAG
WLAQALGIGASLLIFAPAFVATTTQAQLYACLPILMLYPLALGWICYRQAVNLARHKREL
LALSRTDSLTGLLNHGAWKDHLEIEFQRCRREQQGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLGKILRQNLRATDLAGRYGGDEFCVILPGMPLNRATEVMDALRDRFNALAYAQDST
LRASLSIGLAPYQPEHADSIGWLNDADQALYEAKSSGRNRVSAVHGSWLRSV
>A0A0D0RQF5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAIFKIRPRMRTLLSPAVIKIELVGILAWLGALFIDSVSALNVIHLLITLCLLSVWYVH
RVIRSFLMWRVMGGLYIFVLSVGFAYVIRSHMELRIFALPLAVIIVLSSAILFITVGDYL
LSSVQVWLLMWTHIDIDIYRGQELYLLLFCVSSVSIGFTLSFTYLRNLRSVLLVESEIRT
LAETDFLTSLLNRRAFMELFQKLLAEGRYGYFIMLDIDGFKLKNDQYGHDVGDKILCAMA
NCLKSTPGSYCVGRIGGEEFGVLVLGGDDLVVQEYALRLLGAIRASVAPPHHYTCSAGIA
RFSATSDMSAVLKCADKNMYRAKHNGKDRVFQDGEQVGALMLPLFAQ
>A0A1C5ZVQ6|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MDIGRLVESYMFENLTAVESPDECLGEIFKATYLISPYENFYLCLDEDWLDTDKQIISGY
PEKMKLMLHAIYGDSVTKGTFMDVDSTSFDTKLMLPDLWIEHDKPSVYYFAPVHFSEHTF
GYGVLQCSLESKTKIGIVFRNWIRNVNNAIELTRVRSRLTAFSQRDAMTGLYNRRGMEAR
IREMLERPGADTCLAFVIDMDGLKYVNDHYGHSEGDYGINAIATAARLITRNDEICVRAG
GDEFYIIGLGDYCGADMLARINKFTNAIAEENKTSCKPYEISASIGGCCAELTADMTIED
VVHKADANMYENKTARQKLRR
>A0A518GIP5|diguanylate cyclase|EC 2.7.7.65|Planctopirus ephydatiae|TrEMBL
MTLTSDSAVLDLVTSAGNGDVVPYTSYPLDSSRVLLGLVNLVRRAERDTAPERADANLCS
LISPRVFRSLLNSLLFRDPATLRHSQRVGRLATGLAKYLGWEDRNLRAIQIAALLHDLGK
VGVPDSILFKPARLNSDELRLMTKSYLIGVDLLEMCRVDPLIIRIITDSHHRYSREPGGN
AIFSDIHQGARILVVADAYESLSNDQVFRRAKAHDEILKLLNENAGTQFDGNIVSALQRW
IHTYGPPALDGTMNDDDSLIHYYQPASDAELAEAANFSHLFSYMQTLDELYDGFSIIDCS
RRMLVWNRGAVKTHRRPAREVLNTIWKPQVFGYADDRGVPLATSQCPLEAIFATGSSYAA
TLNMTDGEGEPVSVELQAFPLIDRNQRLQAVAEIYRRTERDEASNVSPEVHALKMMASRD
ALTRVANRGELDSQIEQLLKKYNSESQSEVFSVIFVDADHFKSINDKHGHTVGDQVLVEL
ARLLQHESYSGEIIGRYGGEEFIVLCPATDVELAVRKSERFRMSIQSMRFADYPSLRITA
SFGVSQVVNGDTVASLVERADKALYQAKQTGRNRTCHLMTTDARRSAHRFSTDEEEDPLR
LMQRFYIGVGQSVVPKMAGFVEAHRAKLLVVEPGRVKMQCGQGTIFGMWGWTNSTRPVIL
EIVLPELLEEQRGHASRRGPNSPEAICVTIQPKGRPNSQAIFQNRAKLLMQDLKSYLVPC
DRQPGMGV
>A0A5H6P3V8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Adjame|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V8Y6R7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kalamu|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8D9PQR3|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSNTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A1V6G1V9|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium ADurb.Bin069|TrEMBL
MGPSNTGHSTLTDDRPVWCDPAVTPREFFELVGRASPIAACLAGGRGEILAGNNAFAGLV
RSFLAPQSGRLAYLEEIFVAEDILKLQLAEPTLDVPLSLRLRDLRPVRVFGAKAEIHGGS
VRLFVLSEDPEKLESGSNAAAPVKDQRGRLFDALKCTLRVYELHEKIRRIPSMTRELLQV
GDELRLYEEAGRILRQEGLDLEDVTFLNLVDGNLCVSFSTRAELANLTFALDGGTKYATV
FRRGGSAVDPWSGGGFILPLRGREDVIGLMEVKIAEEARALFAENHRTSVGIHDMLLTVA
DIIALLVENIRLYRRLKLRSQTDPLTGLYNREYLLSEARKEIARADRFVRPVAVLFIDVD
NLKGMNDDMGHLQVDVLLRELATIFLNRTRQTDCVCRYGGDEFVILLPGTDLKGARAKGQ
EILASIAQHEFPSLTSPNERHRLTVSCGATEYEHGLSTQEFLARADKALYKAKKSGKNQV
AIWDR
>A0A517ZNH8|diguanylate cyclase|EC 2.7.7.65|Symmachiella dynata|TrEMBL
MNASISSELGNISSSFWIMVLLAVAIAAGTGFAAGIFYARWSDKRSFSKARAGVAQLFQT
VISTIDTAQEVCRLLEKCPGTFLKPNQTEQLVQKRNGLLEAISGLVRRHDPSYDATPSPV
VAPSPEPTPFNVEWTIEPTDPATGLPGRQAFDENLALLMNAGQESERTSGLLLIKIDKFE
NLRSRLGVGDSDKLVKKMMAVVCRSVRDEDLVCRYSADMLAILMPDTDPETGRSVAGAAR
DSIRAYHFRVEEHGPEIFVTASFGYTACRPLDNPDLAVNRGADALSKSQQRGRNQLHAHD
GQSIKHCLAG
>A0A2V3XNF8|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia tropica|TrEMBL
MQRSAQDTANRTPVRVLSSMIMKRPHLVVTLCFGVAMLLVALVGLRQLYNMTRYDLQSRL
RDLQVRAVGVDALIEAERRRLTFLRNYAEHVLAAAPEARGSMLDPAVQRALQASTQVAWQ
TTGEVNGPPVFGTNAATLAGLPGFHRDDVDLPGDIALARAISPLVDISQHADAVQSTVAF
ISTNGVFVISPEQHGMSVPALLRRFSSMNYYRGQLPDRNPSRDVLWTPVYTGLQKGEAIS
TLSAPIYLNDRFRGAVVMDITQSRLLSLQLATADPGDVLENAPPVEFGLLNNNGNVVYFR
NGVLTEERPRRFSLALLQIARDSTGRWMQRGSGYIERRGDYLLYQRIGQTHWMLMAATDD
RELTLAAARRVFSSPLIAAWAVLVLLLVGTLFIVKNIFGNYVEASGRLETLARSDPLTGL
ANRRRFQEAFAETVERAQRADDTRDTQDANMANAGAASDRSALAVLMLDIDYFKRVNDRY
GHAAGDAVLTLLAQILRANLRGVDVPARLGGEEFAALLPGADLATASAVAERVRLAVEVH
AQHLAGPASAAHPEAIPFTVSIGVAVCPADGPAHYEPLLQVADRRLYVAKESGRNRVVIA
DPQTLGA
>A0A806H2X0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri DSM 10701|TrEMBL
MQHIPNEQLAGEWRRLLDQFSPEAAAVLHGVAEQSNEDLAAHFYEQMLADPHAAVFLSHE
QVQNRLSHSMQRWVLTVLTSRPEDDLEAVIDLQRTIGDVHARIEIPVSLVLRGARYLKGR
LRRLVERQAAEAVTRRDAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFAVSQNQ
GAEKERQRAALLDWENQLMFDLAVGSGYESLPRLASSEFGLWFRHKASHAFQGTPESASI
LDYIMQIDQELQILADAGKEQGSLGSLHRVREQTRSIRFLLDSLFEQANELEAGRDVLTR
LLNRKFLPVVMTKEMLYSRQAGGSFGVLIVDVDHFKQINDAHGHDGGDQVLQQVATALSN
NTRGGDYAFRLGGEEFLLVLVDIDAQKITQAAEKLRQRIAEDSFRLPQGEVIKVTVSIGI
AVHDGHPDYERLLRRADQALYEAKNAGRNRCVLARND
>A0A7I6TJ80|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-CRE-03|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLIDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKIAAPDGSDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A7G2JPB1|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MRSRLPTLTPKRPALLHWLVQSPQHTDDAQFQRQMRLTLVPSPATPWLNAAGVALLLLGY
IWLSHRALGAALLVSLLLLTGGRWWLMRVSPPRWPNAMLVTMLLWCALVGATALLAMLSG
RMVLILFAGLLITGLAFWLMQRHAAAPRFALLEIMLLTLPYLVVAPLSRVQNLFLLADII
PLWLLLAHGLIAFYHRQVTQHVTLTAEKQKAAHQDRLTGFLNRAGGEAVMQEVCRPSATM
HPLSHLFIIEFTPLAALYQSHGVLIGDDVLRTIGERLKMLVRPSDFVCRYTGGQFLILVH
GLPYGSEGEFLARIVPPLQAPYDFGAFGEVSLHLNTGVLALTQDYQKVENLMAAAQHALT
INGKE
>A0A5P9HV34|diguanylate cyclase|EC 2.7.7.65|Bacillus sp. THAF10|TrEMBL
MKALLDRAYQSHHALEVIFSSLRWFFLVLSIVVFSIQYVAQPDFQKLMLFVLLVIFGFIY
MGFSDYYLHKSPEGSKMYTTMTKGGPVFDFIAFSALIPLTGGLASPLFPLAYLIILHVAV
YWRFLGGMIAAGLFTLVYSIIFFMQREEATSLHPFIDYFSAVLFLLLIGGLCGIIVSRER
KHHSENSMLVEAANRDYLTNLLNHRSFQECLRKDLDNGVDFYLTLTDIDKFKSINDKYGH
VMGDRVLRQIGDILSSFVPEKHGKVFRYGGEEFALILYYERQSEVTEVLEEIKQAVASHL
FQCKEETFSVTMSFGMAKQNGENPGQLVEKVDMLLYEAKDSGRDRIVCAG
>A0A654AYA4|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. T1|TrEMBL
MTHFITRLRQLRHSDHAVAADVRATLVTSLYASPKSLVIGALTSTGIATVVAVTSGDRWL
AGFAVLIGLVAALRIIGIVQRVPDQQAADVFAVDRGAAERPRAGQWEFYYRIGAFAFSAL
LGMFGLLTLTRTADGVLHLLSVTTAIGYAAGIAGRNAGRPTIALAQLCLASLPLAAGLLL
SGEPLNAVLAIVIILFVLAMIDITLQTYEAILGATIAASEKTALAEHHAAFARRDDLTGV
ANRTAFREWFERRLHRLESTGELLSIHWIDLDRFKEINDSLGHLAGNVLLTEVAQRLQTA
FVTDGGTIGVAGDAIVARLGGDEFAVVCAIGARDDARTIADHILDLVAQPVAYAGRRLTV
GASLGVAIAPIDGGDADTLLKHADLALYRAKESGRGAFCFYEPVMDEKIERTRALTSDLH
GAIARGELWLAFQPIFDLATHRILSCETLLRWDSPCHGSVSPAEFIPIAEQSGLIVEIGA
WVLREACRHARDWPDTVRVAVNLSPIQLLSPGLAKVLKDALDASGLAPGRLDLEVTESVL
LDDIDASLAALSAINRMAVGTTLDDFGTGYSSLGYLTKFPFQTLKIDRSFITALDDNPAS
MAIIQTVVDLAATLGMQTVAEGIETPTQLAQLRRTRCTAVQGFLLARPMSASQVANLLAD
ETPRMRALS
>A0A518JQF3|diguanylate cyclase|EC 2.7.7.65|Rosistilla carotiformis|TrEMBL
MKRFGTTTRIALAMSMWTATVLLALRMTGLLNDGAAQQIQSRTRLCEAVAVSCSQFASRN
DWMAVEVALRSLKARNPEVLSAACRRMDGTLDFETGKHSDHWSQRTSDLSSSTCIQVPVL
QGDKAWGQIEVCFQSPIAAGLLGFLALPSVKLIVLTSLACMLGFSILLRRCFNQLDPDQA
IPERVRAALNTMAEGVVVLDEKFRINLANQPFADMLGCSVDVCQGKNIDSLPWETQDNRP
LSQLLSEMHGDNPVDFENIKLQQSPSSKRTLKPNASRILNKQGDCKGMLLSLDDVSVLEE
QNEQLRFLATRDPMTSCLNRRSFFEHLEQTWKSAFRYKHPVSCLMVDVDHFKGINDSFGH
AVGDEVLKGVSAALLATARDTDFVCRYGGEEFCILLPHIDIDGVARAGERFRTAIEALQF
PQLRVTASLGCSSGDLGAESADQLLEQADQALYFAKRNGRNQVARFDRLEATPHAIETQP
PADAIQSEDVLLESIKLLIRDARDAGATSVSFDLLNATLEANAE
>A0A8H9CAE2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIVSILRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A8H9S9F6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKEITSTPRPTFKSTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDALAANETLATLGKQGQFAVAEVLNAHKKRFAYWSWNPEENNDTLGALVS
RWLFPDPVAQPIMHNGNAIGEIRLTARDNLISHFIWLSFAVLTGCILFATAVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRSSIAALMHDASAKTNTALLFLDGDNFKFINDTWGHAA
GDCVLIEVARRMVEFGDKRHQSYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDL
HNGQTVTMSLSIGFALAWESASVEALLEQADRNMYQDKNQRTKAIT
>A0A1S7QCE4|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. CFBP 5621|TrEMBL
MFTVLECVAIQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVFAVIGFWLALTARSQAAYSPVIVGTLITLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWVSFLLAFFLFRGIGSWKRIAAPAASAI
FAICALHFTTMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSSTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGRDEASLVGQNPDDLFKAIDGQPAYLP
RHTPVEAVRERAGQAQIFELSVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDEDDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTRAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGRDHESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKVAVNVSPLQFSLANLGHVVCSVLMQTGLSPNRLELEITEAALLKDRKTT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVRTTTRKKHSV
>A0A1W6K8S6|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MPLYLRFLFPLIGLLLVTDLALATHPGTTPHCPALDAIDPVQREALMNHVCFLSAAPDTP
AHRAESPRELPADIQWTSARGHDLVFSHTDSVYWVRLNVRNSGDSQKLWYLKLNYPLLDE
VTFWRSSELVEPALTTGDQHPFLSRGIDYRYFLLPVTLGAGETQTITLRIQSSGALNVPL
SLKTPETTIAESNHLTLLHGFFYGALLVFAVFNLLLFFSSGTGYYFYNAFYMASLGLFLF
AMGGFANQYFWPDSTGFANTSIPMLMSISSLAMTLFGRSFLEIPTNTIANKVLTGLALTS
AGLFIMAFLLPYNRSIVLNTGIALLIIACLFIIGIIRWRQGYSPAKWYVVAWSGMLAGAL
IYSMAAFGYLADFLAREIFMQAAVGAQVILLNYAMVQRWRLLNKKLLDVEHNARTELELK
VHERTAQLRSAMRELEKANRQLATLSLNDALTGLHNRRHMDNLLPELCAEARRTGQPLTI
ALLDADHFKTVNDSWGHEFGDRCLQHIADILRRHVKRPRDVAIRFGGEEFAILLPGTDAN
GALGVCEGILEDIAAIRVPADDGTPVTLTMSAGTATLSQGDDERDLFRRADEALYRAKAC
GRNRTEQATPEVS
>A0A240EJC4|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MNPNRVLTITTMLFRMVVLIVLIGVSPASFAQTALQKTFVVAAHERDFIARFIFSTIEKQ
SNIAFQYVNYPDFSDRLEAVESGYVDFAANVTFTKNRSSRFIFSQPINIEPTYLFNIEGK
PFDDMHVIGTTIGTAFNDIIQRYYPNKRVLSFNDYDVAHESLLAGDIDGYIGTFLQLENF
LSAGFKAASINDRLSIPPVSIVTNKPQNQPLLTLFSDIIAQDEVEKEIRQFIDDYITEIA
IKQLRKKVKSSGLDLDATVEIYLNPRPPYVFSSSSDQPTGISVEFAKKICTLNQLKCNMV
YDPTETWSASLQKLTLGERDVTPPITDFAHRQHLLWFSRPYATINGVIAKRIGYKEEVYR
HISELFAEKVGVVENDVFSSVTRRSLPNKTLTYYCNTERLIKGLITGEVDYAVTSKVTLD
TLLYENTITNVTEDRHFRPFYQSDLSFGFPKTERGQTLAQLFNRTLDFIDADAINRHHQP
PAKWRELNEKESDKRRLNIINALLALLVLVTFLFGYITNHRANHDALTKLKNRHALNRIS
KQFLDKDNGLIYIDLNRFKHINDTYGRTVGDQVLRCYAKRLRETIDGEIYRIGGDEFVAI
TECSTDELDSILKQLESYPFIVRGSGVTLTLHASLGVFPPNTSALRIKQLLIYTDFAMYE
AKRNDSVRSIIIDDNKLTDLIAIHEPSKRSYQPTPEL
>A0A377M0M0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MLNVSWDPVLIAISYLVAFIASFVALENAGKIPLSSGKAALFWRFAGGLTLGVGIWSMHF
IGMLAMKIPMIMSYNFWLTLASMGVAVVASMLAMNIAVTGARLSPFRLLLSTLILSAGVV
SMHYIGMAALMLDSPIIWDHPIIGLSVLIAVMASGAALWLAFHLRHQRKGIFINRILAAL
VLGAAICAMHYTGMRAAQFSDMAHTLPGGISELGLSIGVSVTTLCLLGMMLIISLIDSHW
RTNRLTDNLQALNRQLELQARFDALTGLANRHQMDLRMQDCLRSALLSNKQFAVIFLDVD
HFKQVNDTWGHNVGDELLITIAQRITARLTREMTLARLGGDAFILLVPECDDDKLQSPPL
NATPMMCAARFPYAGIR
>A0A1V4VXQ7|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin117|TrEMBL
MRPRSIVHILYVWLVVGLAAWQLYLLFPALDLDRVRELLSIVLLGVLSEWLAVSFPHGQL
SGGFALVLSAYLIFGPAATAWVSGLSTLFGQGIANRGNPVRTTVFNAGQYVLAAVAAGHI
YQFSGGRLGLSGFAEILPLAAFTVCYMGINHLLIYFYLLPKRRYYPGPAWLDAVKWDSLT
YLFTVPLGLLIAMIYIYTGLTGIMLLFSSVLALQLIMRHYIHLHVANRELKAFYDVATIL
EKNPEPAELLAFILRRAGKVFPYHSGVAYLRSGERDSFAPVAATGPYSKHLSQTKVYSGE
GIAGCSIADRKPEIISDCRTDSRTRNEAGLCQIMRSLLIIPLLSGEEELGVIVLGDRRPM
VFDEKHLHIMAVLGGQAALTVGKSVLAGRLEHAASLDVLTGLLNSGVLFHAASEICGTAG
GSGVAAGLMIIGVDRFKAFNDRYGRAAGDWTLAELAGIIKGATRGDDLAARYGGDEFAVI
LPGASGRRLMDIAGGIRDEIEEHYFLREAGKQARITVSIGAAEFPQDAGDAAGLFKAAQR
ALDKAKKDGGNRVVSAAVSIIGLPRK
>A0A564SEA4|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGVALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6N2XXF4|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MKLLSLTEKIKLTKQQELEFIDVLEDDIKKYFRIPIFFIMLFQIYNMVYVSVYTDFTYYT
KSSKIYMLLYTLMFIICVLGLILLHKKNVKKGLLLKVQNYYIVFLIMWSLAVTIYDNRVS
NNISVHIITMLSIAILVYLPPKLFVPLYLFSDIILITGIELVKHGEPLGSHYSIYVNSTW
LTIMALFVGYYHYQSMRQTFLNQSTILEKNRMIEEKSAELDFIAHHDSLTGLQNRRYLAN
CLNNIYLESRDSQLKTGVFIIDIDDFKSYNDTFGHIKGDECLKRVSNALNLCLSEGFLIR
YGGEEFVYLLKNTDLEEMQRIGTELCHTVERLHLLMPNTSSREYLTVSIGGAIGVLNGEE
SWQAVLEQADQALYKAKNTNKNKCICAVE
>A0A3S5AWT9|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MKVKYLIYFFTFAIMLSFAVFIANGLIKARTSYEQSLENLYKISRTKEVAEAFQATLLAH
RLKRLGLADKSVTQAEWQQADKQARDKIAIVKANVDADLALRLGIRQKIAILSMLDWMER
LLDNDSRQVTQVDTANSNLFNINSAYYIVQTTKAFYRYTYDTRLINADSFLFLEAVRLNN
RLNMSLTELIDQIIDVNLSSLERKNAYLKAIQLTGVFTPLGTRLAFLKLAYNDPQIAELV
DEILRNISNNRISNISDGLYQAITHNTVYDINLIASYIEEMDELSQRLYERSFELEMAAS
EAKKYDSQTAIYGMISLSGLIALFILLPSMIFCSNITRWLTKTHKNILRLSQGDMNIDEN
DAFYSKELIAISDAITQLKQYNQVKIALENEKQQLIKELEVSSFFDPLTNIYNRRKFFLE
CEMLAQSSYPLAFCLIDIDNFKRLNDTYGHDVGDRVLVMFAQSLSNTFRSSDIFCRYGGE
EFALLLGHCSLENARSMMEALREQTQQMCLELLNGKRVRFTISCGIAAVGDLAQLHPAIK
QADEALYFCKKTGRNRVSIYTPTGFI
>A0A1Y0HIF1|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MEMNNNNHIAEMVFQLAEETFAKLKSLNIPPYPKYYHDTFVETLQKSGDTELMDLTKKHS
YLFSNAQQEEMVSETCFGLMKKGLEEFVKTNDNLKFISDETSINIDNIKKDYESVDTHQV
LQAFDNFQGKILHELQAADETIAKLKLEVERLERESNIDPLTKAHNRRVLVKDLEELLSV
GRDRDMDMHLVMFDADDFKQINDSFGHIAGDKTLIFLSKLIQNSLRRGTRIYRYGGEEFV
VILNRTSFEEATKIVDRIIKETSDSKLLYKNHDIHLTLSAGICSHKRTMSADDLLDTADK
ALYEAKKSGKNCFRSAH
>A0A7T5UBF5|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MNELLNVNEQRDNDEPDYNQVITSEWMQLIATTSQKSFNLLRTLAAQKAADFADDFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIAVILTNTGTHLAELISHQKKIGQVHARIGIPVD
LVERGARRLKWHLYEEIAQVASDKALCFDAMRFTSISMDIAIEIMSKTYSQSHDMAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSDFGLWFNHKGK
SSFSNIQGIRTIATIMTETDEYIRSYSNSALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTPLSIAMIDIDHFKSVNDTYGHAT
GDSMLKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKAAAHTIIDRLRKKIQDHPIHL
QNGARVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYALE
>A0A1V5E872|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MPQRKKDERRRAGSKAQSGRVSSAAEPRGAMNRLMLELKQAEEKYRNIIENIGVGVAMID
PQMRILTLNRQMREWFPDVDPAVKPLCYKSFNDPPARDVCPYCPTIRTLRDGQVHEAVTD
TPMKGGVRNFRIIATPVTDAGGRVVAAIEMVEDITERQRAAKALRASEQRHRSYIELTGQ
LGWTANAAGEVVEDLPAWRAFTGQGEEEIKGAGWANALHPDDRERALEAWRKALATKSAY
ELECRVRRRDGVYRHWLARAVPLLDEDGGIREWLGTLTDITDMKRVEEELKKSEDMYRTI
FETTPAATMIVEEDTTISMVNREFAVQTGYDAKEIEGKKSWTEFILKEDLGRLMAYYRLR
QLDPEAAPRNYEFRYTDSKGRIRDVYATVSRMPGTKKTVLSLLDITDRKRNEESLRTIAE
ELKSKTHAVEEMNAALRVLLKQREEDKIDLEKRILASMKELVIPHLRELKKCLTGQKELT
RLQILESNLQGIMSPFAQKLSLQFLNLTQKEIQVANLIKEGKTTKEIARFMDLSKFAIDT
HRARLRSKLGLTRKKANLRTYLSSIME
>A0A1Y0N6E3|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MNALVQSLAALGGLRDRDALDTELVRLVLTSSGVSIQSANLIRVVGEGDDRRCLSLSALS
LGQETATRDLLWSDWSLLPKVSDFPVRQKSLDIGRAATNPQDAGHVVLPVGHAQSLQILL
EVRAPKPLQAADIDLLQSILLAYQNLLGLLDYGERDSLTELLNRKTFDGAFFKATADQSN
TPPDNMPERRHDSPDSGVWLAVLDIDHFKRVNDNFGHLIGDEVLLLMARLMRGNFRFHDQ
LYRFGGEEFVILMRCDSAAHAEGALERLRERVQAYAFPQVGTITVSMGVSSLLPNDTPSS
AFGRADKAVYYAKEHGRNQVCNYQTLVAEGKLVEQVADEMDVDLF
>A0A5K1HZC7|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MSPPPRARRTPGWLWLSLMSFTALMLLIAYETRWVHPDIHAYFSQSGNLTGQQLATRSRE
YLEESLGILLEESDPDAVQRASFQIELGYGLFDIGLYRNEYACTEPNLQRLDALNDSLGQ
GVVPPPDSLSQGLLQPIRCLTEIEMDQLDYRSAVTNRFVEETRHHQTLVLVGSLVIYLLG
LVFWGMHVFKHRLADRATRESLRWMAQALQDPLTGIGNRSALHDDVLAEKGGTMALLLID
IDYFKQYNDALGHPDGDQLLRELVALIDRALSGKARLYRMGGDEFAALLPCDDPRTLASA
AASVVEEVRRAALPHPDHPAGTHVTLSVGGVQFTAEPEAFAAAYVAADRALYRVKAQGRD
GWQLGATAVEESRYGFTGK
>A0A653L7Q5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 8I-beige|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAGLPLENNHYMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A6N1ANR6|diguanylate cyclase|EC 2.7.7.65|Azospirillum oryzae|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYREGRGGERSSAPASFQAWCQAASRDDL
LQQPAVQKLATLHEQMHRQARLILLKSSGGELPTEAEFEGVVGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETRLDEGYEVIERLRVDLMRSPVVLPDG
RMIPVTASFGLVEAVSDLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEPKPAAAKAG
RG
>A0A5K1I7A9|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MKDDTAFQGSAWPPPPAVSCHTEESFRHDHSSKVATLSERQANSASSQDVTAALDAEKAW
SRVALNTIGDAVLTIDLQGSVTYMNRLAETLTGWSASGALGEPLSRVLHLVDGKTHQRVI
TPGRCAIEEDRTVGLALDCVLVRQDGSKLEIEDSAAPIHDREGRVTGAVIVFHDASQSQA
MLEKMAYLAQHDALTGLPNRVLLMERISQAIGLARRHRHLSALLYLDLDTFKSINDSLGH
AVGDSLLQAVAARLQACMRSTDTLCRQGGDEFAILLAEIRQTEGATKVAEKLLDVLGKPY
RIQGHQILITLSIGISLYPRDAEDADTLIHNADTAMYHIKRNGRNGHQCFMAEMHTLPIE
RRRIEPGRQWFFQPSQCLFDF
>A0A448SVC4|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MTYIASISSFYSDACITYATLSVAYFALSRNAPFSYQSAIWKRILFGVLAGLAVLYLNQT
RLLLAGDIYYSFAMIPMILVLFFGGAVSGMVCYLVNFGFNGGFTLDNLFIGSIILPLLLS
GVWRKKSNRVFYLTIGVIALYRIAVVGSLVNFRELWLDILLYQAASALCLAICYHALSFK
ERHIHAFFSMRNKATTDSLTHINNRASVDYKMMLQHAQRESCGLMLLDLDNFKQVNDTHG
HLAGDGVLASVGAILKDCVRDEDFVGRYGGEEFMVITSSYEPLHIAAVAERIRSRVEEFD
FITESGEAIRLTISIGTSLYLPGMSVEKAIEMTDEALYDAKRQGKNRVVSSRLMSLSQLG
ERFSPMAAKKS
>A0A0M7FEE7|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MFRNVFALKSLERYFLTLAAGVALPVSMLTVIVVQQNWRSLAATDDAMRGFIVVRTTLMT
MEAVSAERGPMNSALGSDLPVPENILRALAEARQRTNAQVADLLALYRAPLNPNGAREFT
NIQRIRESLLNARASADAAIAAPRANTSGHNLWTVVGDMVAVVPELRAAMSDGIGLVARN
QGEDFDLLSLALLAGELREQAGLVGSTFAPALSKRRTLTASDQLRIERVIGRIDELRALI
DANIASMPRYASSLAYRELQQQYFGDGMSYLDSVRAIAERAPEESLVSMYELGANYVPRM
KSIVRFRDLMLNEVEQRIGENRQAAIRVLLTTLAAAAMLTAALIIGLTMFRKRVIRPFVR
ATNIIGAIAKGGDVPPIPADQYRGEVNGMFKALNVLNDNATAVRKLELERDRLIQDLAIM
AETDFLTGLLNRRAFEKRLEASLDDIRNDPQSGLGFILFDIDHFKSINDTHGHATGDEAL
KTVADLCRKTFRESDVVARVGGEEFAVLCRSRNPDRVRDIAERMRLSIAQTRLSAGAGAS
FSMTASFGVAHARGSDTAALENLSRRADELLYKAKLTGRNCVLLEQMA
>A0A8F2UXC1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans str. Sal610|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7W4PUY2|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7W3AGE4|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLFDNSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSPDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMFNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A5P9CRC3|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MLDDDFKKSTANLKKAVPLMMQNHVAATPANYALWYTYVDNAIPEMNQELDDIIENYGLC
PPAAGKQLYDSFVASHSETNMKELKANVEVLVNQVASSMTDTLSDTSHFSDVIDKSFENL
ERFEDQAMSIEDVTKVVRQLISESKEIRNSTSFLNTQLETAACEIQRLKEQLAEVQQDAL
FDGLTSLYNRRSFDNDINVLCEAEQTMCLILADIDHFKNLNDTYGHLFGDAVLKGIAKRF
QLSSRDGIHAYRYGGEEFAFIVPNKQLRIARQFADSLRRSIEKLSVKDRRSGESIGSITA
SFGVAELQPGESPESLIERVDKLLYEAKQLGRNRVMPI
>A0A5C6EN22|diguanylate cyclase|EC 2.7.7.65|Rubripirellula reticaptiva|TrEMBL
MGKRLLASLRVAFSLVCVGASLILGAQWFGYMPDAEAIQSSARQKNCETIAIQSVRQISE
RDWVALRSTLQALVDRDTELMSIGVRSEFGTLRLDTGHHEKMWNPTTGATNAADKAKIPI
TLNHRTWGHMEFCFRQSGSNSFDRLLSNPTVQFVGFYILAGMFAYTVFVIRMMGVFSNTQ
VVPDRVRQALDTLAEGLLVLDGSGRIVLANQAFADLVGVEADLLTHKRASELEWVADDVA
ESGYPWMHAIEKSELQSEQMLRITLDDGSQRIFSVNAAPLGKDRTQRGALATFRDVTHVE
EHRAELERMLSLLRSSRDEIERKNRALEILATQDSLTGCLNRRAFFEKFDSIWMQAKAND
SALACIMVDVDHFKSVNDTYGHHTGDEVLRAVAQVIRAQNESDGVVCRYGGEEFCVLLPD
MDIETALIRAEKIREAIAAIRLDDPEELRLTASLGVSELRFRSHNPQELVNQADACLYVA
KREGRNRSIVYNASYSIIQDTEKILEEDKHDRVDIPFQAVIALVSALSYRDTDTAEHSRR
VADLCARAGEGIFDPAERYILEIAGLLHDIGKIGIPDCILLKPGKLTPEEWEVMGRHDRI
GVEIVSGSFECLKLTEIMANHHAFYGGHARDPELPIGEAIPLAARLLSIADSYDAMVSDR
VYRPGRSHEEAVEELRRCAGTQFDPKLVEHFIEKISSTRAIFATGAIALRKQNALAIGSH
VQALVGAVSNQDITELQTQAIRVASLANDFQLTDIANVAVSIEQLAKTEDATWVALLRQS
YDLVDLCRSTQSDFLKRSLERDAEQVNSQAK
>A0A3Q9E9J8|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MVNWAAWLMRAATLGIQYCQSKTDERKLIQTNIGVYIAMLTILIFDIAFLINGNQGLIYS
GLVQTPFLMLLPSVLLLNLRGLRFEATLWLFVLVMLDAFTALVLAQGVTIGLHYYFLLFA
ILPASFLDSRQWLTTAVLFLINMMLFAYFQSFGWQAHPAIAEVPEAILGHLQVLMIGSCV
ATVLLLILISEFYSAENERNLQHLADTDTLTGLPNRRAFMHRLEQVIQEHSPFCLMIVDV
DHFKRINDSAGHLAGDKALRFLANELRMHIRANDFIGRIGGEEFAIVQFSPSPSDNINRA
ERLCRDIAATGIEIGAERLKLTISIGVCLVTPPAKLVNVLTLADAALYEAKSNGRNRIEV
TESLGGF
>A0A1V5LQT7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin419|TrEMBL
MMDIDHFKNVNDKYGHTVGDAVLVVFAQVILRCIRKTDLVARYGGEEFIAILPATDTRTA
VSIAERIRETISTEPMPKMNDILVPSITCSLGVATYPIHADNKNNIIKVADIALYKAKQG
GRNRVEIYNSTFDINVLEK
>A0A645FQX8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MMIDIDHFKRINDTFGHMVGDEILLLVSRLMQNTFRSSDLLYRYGGEEFVAIVAAENEAI
ARNVFERVRLAIEAHSFPRIDRLSVSIGYAEVDPEILPVEVLSRADRSLYQAKQDGRNRV
YDFQELVASGIFPSPSYGDAELF
>A0A645A6V0|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MRFGGDEFVVVLEGTKADDARLVAERIRGCVSELRFLECAPNLTLTLSIGLIEGDAPISE
LIAKADRAMYASKNKGKDSTTVFQSDSADSAFHMKLS
>A0A822PNW9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRV
LIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7W6IJ20|diguanylate cyclase|EC 2.7.7.65|Devosia subaequoris|TrEMBL
MTARVLIVDDIPTNVRLLEARLSAEYYEVLTASSGAQALDICDSQDVDIVLLDVMMPEMD
GFEVCRRLKANPKTHHLPVLMITALDQSSDRVQGLEAGADDFLTKPVDDTQLMARVKSLV
RLKSLTDELRARALTGQQIAIEDALRAMDSISASEGSVLIIDTDRRHAERIQGYLTPDHK
VDILTEPADAVFQVAGGGYELALVSMSLDSFDPLRVSSQIRTVEHARNLPIILMADVADK
PRVVRALDLGVNDYISRPVERNELQARVRTQIRRHRYAMELRESVNNTMALAVTDELTGL
YNRRYFDRHLNVMLHKAQEQDRDIALMILDIDHFKAVNDNHGHDVGDAVLREFAARLKRN
IRGVDLACRFGGEEFVVLMPDTDTGQAEAVAERVRQSMVEKPFDVGPARPLSVTVSAGVA
LKESQADTPETLVKRADVALYRAKREGRNRVIFDAA
>A0A822PQZ7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A751CU56|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAVVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0A8USP8|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MGDLDHFKKVNDQFGHLAGDEVLRIFGNLLKQHACPNDDYCHYGGEEFLLVLPKVEKNLA
LERAEQLRSALSVAPIIYGASVLSVTASFGVATSPYDGQTGDE
>A0A0H7HLP6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSSSFVTSPWFRFGFPLLLLVAIWLGLSNVVLVIKSNLGMAVNLPYILFLIALTVAHIFK
QSRIAMVAMTMLLAYWLIQIRLQTPLTVNSTMLELIMLSLLLPVACFLPYAYKNAGLFSK
SFLSYLAILLLFIFWAWLTQLHIGETDHSSLTEGIFFVVPQISRLPLVVVAYLVALAGIA
AISVLTRNQILDVVVYSSIVLSMNAFVLFHVPYISTIMFTLSGLLILVYLISAGYEMAFN
DPLTQIPGRQALDQDLKHIGRKFTLAMLDVDHFKKFNDTYGHDTGDDVLRLVASRLREIN
GKARVYRYGGEEFSIIYKGKLAKEVLPFIEALRQDIESYELVIRDTNQRPKSHAEGAKKR
SRKSNSDIVTITISIGVCDSELYRHPIEALKAADGALYKAKQAGRNCVKVAS
>A0A5V7XGU8|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSVQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3U7XS49|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7Z8FCT8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A564WVF7|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MRKKNEITEYVAAALIFVCAVAVSLGIFLVCTQNSIERNSQKVIKTNVSRQSEHIKAILD
IHYGYLRGIAKEIGKSEELVSDENMEMLISLEEETALERTALIEADGTAHYDNGAEKNVS
LRRYFKEGMEGKETLSDPLESSVDKETRVILGVPVWKNGKVIGVLGGSYNVTALSRMLFN
DFFEDVGYTLITTSDGEIIAYDGDFAYHEIEYGDNFFEFYDDQTLIFDSSLTEVKKDFTV
GADGLMKIRIGNDYNSDRYLAYTDMGLNDWMICYVIPVSEAQKSYNFVRRYELIFTIGFC
VMVSMLFLWGFVKNRSKDKQLIQAAETDALTSAYNKRSTEERIHNVLQEHPQEPGTFVIM
DVDHFKEVNDIYGHITGDKVLHKFGEVLHEHFREGDIVGRIGGDEFVVFMRKTDSREVAV
SRIESLIKKVEELSFTEMNGKNITISAGMAFAPEHGTGYLDLYKNADTALYKTKQNGRDG
YNIYEEEKR
>A0A2C6DRS8|diguanylate cyclase|EC 2.7.7.65|Budvicia aquatica|TrEMBL
MTYIASFSSFYSDACITYATLSVAYFALSQNAPFSYQSAWWKRVLFGVLAGLAVLYLNQD
RLLLAGNIYYSLAMIPMILVIFFGGAVSGVACYLVNFGFNGGFTLDNLFIGSIILPLLLS
GVWRTKTNRVFYLTIGIIALYRIIVVGSFVNFRELWLDILLYQVASALCLAICYHALSFK
QRHIHAFFSMRSKATTDSLTRINNRASVDYRMMLQHAERQSCGLMLLDLDNFKQVNDTYG
HLAGDGVLVSVGAILQDCVRDEDFVGRYGGEEFIVITSSYEPQHIAAMAERIRTQVEEFD
FITENGDVIRMTVSIGTSLYLAGMSVGKAIELVDQALYDAKLEGKNRVVSSRLMSLSQLA
ERVNRMVAKKPKRQ
>A0A1F2PFV9|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MERSQSITANHQIRMTIVGLCLLGTIFVAVYFNYFKGIDVVYTHLFYVVIVLVGLWYKRY
VIQVAIFLGGFHIIMDYLSQGAFLMAPILRASILLFVASGIYFLINQLESSHKNLDRVMK
SVGDGIIVVDLEKRVTLLNRVAEELTGWSSDEAQGKRFELVFQLSHENPEYQVSNPVDEV
LKTDHSTVSSHHAVITDRQGHCFHIEDSATPVKDGDGATTGVVLIFRDVSERVAQNKRIE
YLSYHDHLTGLYNRRYFEEELKRIDGRRHFPLSIIMGDINNLKMINDAFGHLTGDQVIYA
AGKMLKKFCRPNDVAARWGGDEFVLLLPNTDTETTAKIVERMNQAVALAPVDQGMLSMAF
GWDTKKNLSEDVLAVFKNAENYMYKHKLQMKPQVRDTTIHLIMASLYQKCGAEKNHGKMV
SQYARQIGEAMGLGEKELAALEWAARLHDIGKVTLAPGLLDKTGTLTPEEWLAIKRHPEI
GYHITNIAADMVEIALAILSHHEWWDGSGYPKGLSGQKIPRLARIIAIAEAYDAMVSDRP
YHPALSPSQAVHAIVHGAGTQFDPTIAGVFVSRVLTEQTGCGQRQI
>A0A3V2FSR6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Braenderup|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F6H1C9|diguanylate cyclase|EC 2.7.7.65|Methylococcus capsulatus|TrEMBL
MKNRDVRSGTGEAGSSSIRIAQSCAEDPREAVREFHAGVASQQPALVTFFCSSEYDLDAI
AAEIRRLFAGIPVVGCTTAGEIGPAGYRDHSLAGASFHAVADILTGLRQFDGARAYALAQ
ALLQRLEVSAPGARPENGFALLMIDGLSVRGEEVAHVLQDALGKLPLIGGAAGDGMKFAK
TQVYFDGHFDTDAAVLTLFSTPSPFQAFTTEHFAVTDERVVVTEADTAHRIVREINGRPA
LREHARLIGGTDGVAAFPGHGDTGDLLIRSADRALYAAKHAGRNQVKCYAGNGSGDSAWA
ASHSKA
>A0A8G6YYP8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATVAAIWLPNAILTATLLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A288QWU1|diguanylate cyclase|EC 2.7.7.65|Weissella soli|TrEMBL
MFKTNLTTKKYRNKLLMHIYGQSIGLTMLVGVLLYTEFFDGIGTNIIYLLLVGILIFLFL
GIKRFFSLFNKYENQSALYQDSFEILVNGSFYIVDLEFNYLYMNESNIEFMDKYYKLHPK
LGENVSKYLTPLHMKAFKDNVNAAISLGFQTSEDILKNDGQDLYLYTTYSPVKNNHGEIY
AICCVTTDISDSVQEKERFTELIYQDPLTNIFNRRKVSDYYKMVQNENKKIWVLIFDLDN
FKNSNDTYGHVTGDRVLVDFSNLLKSTFPSSAVIARWGGDEFLVLVSNITFATLRMIQAT
IQSNISNLDELGISVSMGEAFAEDTMNHDLNYYIDAADLKMYEQKKFQKENYRRIAEVRQ
Q
>A0A5J2K5M2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Napoli|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQHSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3KVN6|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MLHLLTLSSLGRDLFNIKMLIVILITIGLITLMTILTYLLEQQVHRRQNRYWTIGAHGAE
ALSVLISMILLRQIFITLNSGSIISWTYATVQLTILLFSLNTMRNLAVEIINLLMPLFIY
GQAIWLGHSTQYLPVFLAMAIILISTVVYITHNYQELHATQWKYLLFQILYSGTWWGVIW
SVHPFKLSHTLVIILAFVLYMWLIRLAVNRVQKFFNEVLTFDQQVNYDELTGIRNRASFD
THAREVFAAYQHHQMGPVTMVMFDIDHFKAFNDQYGHLAGDAVLRHVAHFVELELNQRST
HGQIFRYGGEEFVIIFRGISALEAGQIMRTIQRKLKTVPIKFNAQTLNVTVSIGISELQP
TDQTFTDWFVRVDDYLYQSKQAGRDQTTVESQLLTD
>A0A8F9IA88|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A1S8SLP0|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MDNKLTSKEELIIKMEELISNNEGPFSIVVADIDDFKNLNNLYGNSIGDEVIKKLISILN
NNLSSTDMVFRSGDEFNILLVKKGAERSFMELEEIRRYLSDNTFNLNENSEDNVYFTLSF
GVASYPRDAKNVVELFRVADSALFRAKELGKNRICLSEAESMVLKSNYFTKTQLDRLSRL
SKATDRTEAFLLREALDDLFKKYSK
>A0A607Y588|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Albany|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDNRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5H5RAG3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mississippi|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N2RPB4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MNDENFYKQAVDLDETSLSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPMSREFANLKTDAVLAGMWMGLMGVNALPSAA
LLMIICMNLMGAGGVRLFVTGLALMVVACLVTLQLTGTSLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATRLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHREATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRITLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRIHEGLRGLRLACAPQVILHISVGVAPLTPQFSHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A5I3FDH5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A380TUQ8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MQLLDSPIFELSPIAMWLEDFSEVQKQFDLWRSQGVENIASFLLEDKSRILSCAHKIKVL
HVNPQTLKQFEAQSFEDLTANLAQIFKADMSSTHLNELVALWNGETLFENTAVNYTLTGH
RLDIRLRGTVLPGHEHDLSLVLITTEDITPYANAQRLEEKSRLIAEARFQYSPTSLWVED
FSRVKARLDHLRRLGISDFKTFLDVHNDFINECLRDIMVTDVNQATLDLFAARDKDHLLK
NLHKVFQNETQQTFRHQLLELWDGNIQHNCEAVNYALDGSIRHVLLHFAVFPGFEDDWGM
VQLALTDITARKKAENYLEYLGKHDVLTKLYNRSFYSTEINRLERNNLRPVSCIFLDMNG
LKAINDNLGHDQGDSLLRRMGNTLNQLIENTQYSASRIGGDEFVVLLPAADEAALNHCIE
SLHELLMVDNQFNNHQPISVSIGTATSQPNERVEDMLKRADTAMYEHKKTYYAENDRRVT
NYNPANDQ
>A0A5I0BB09|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A484NSU1|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MKHSTEVMALDWEHTHSRYSAEQCQLAQDVSARHTAALAEYFYDCMLADQGAAFFLSHEL
VQTRLRHSMQEWLLTVFDARDLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLARRM
HELLHAEPAALPDAVLGACRYVSEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSANLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHHPPGSAQRAQALQGIRDATQALAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPMSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGPQALSVADALRRRVQERPVALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAEDDTDVPASAPVSHAAGYRPVRAGV
R
>A0A5H9E4R4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanleyville|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4R8QXW7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MSSHVMSFRDRAEEIYAARTETLDGIRLLRPVWLLTAICAPGIGAAAITLAFEGMSTVPV
VCLAISIPAFAWGIRYALKRPITYAESVAYVVYCDVAITVGVCVVTQTGIAFLKLVWLVA
ANTYAFAFHGRLAMALQAAATALATGLTVGGAIIRGDSSTPALITTVATVILVNAVAAWA
IYAGMAQFTESARDKDRLARHDELTGLLNRRGLQQACANWAGGTIGKHAVVAAIDLNGFK
SINDNHGHQAGDQVLRKTARLLQTLAGPDTWLVRLGGDEFSVVAIVDSNRVLDYQRAVED
ALADDAPPVDASVGVASEELSRADDSAPLSLAAVVADLLVKADSAMYAVKRRVTSEGVNL
IERRTIAGAISARRRGLGL
>A0A398TU17|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A0D5YFW2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKNQEELCANLNLIFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A5Z1L165|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A726JHI7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MLHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377PK24|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNPLQSLDVLYINACVTYASLSVSYFVLSKHNALNSHSSLSRRILFGVIAGLISLYLTRS
KMYFTQEVYYSFEIVPMLLVTFFGGGIAGITAWLVNFATTGGFVLDNLLLAVMLVPVLIA
KVWERNTFRTYLKTIVFITLYRVVIVLPFLHTKDHVLDILLYQTVSFICLLVCYQTLSIK
RRSVDAFFKVRAASLLDPMTKVHNRQALEQQMQALSKSRSPCCLVMIDIDNFKSVNDTYG
HLAGDQVLIEVAELIRLITRSSDFVARFGGEEFALIINYDDLNRAYHICERIRLAISNRK
FFLSHGPKIHVTASFGISLFDGKTATLEETLNRADNALYTAKHSGKNRVVIE
>A0A427LFI3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MTFNIDDIDASLSALNAALKEHYLRGEKLLYLILFGDLTDHNIIDNDSHLHCQFCEWLTL
RMRGDTLDRNMVLSISRNHDAMHNITRMLMQAVVSGTTTKELVSQYHGCQLAFIDSIETY
RSSLSTFRNQHDTLTGLPLRHLLYQEYPSFLERCRRNLSEFYVLMLDIDRFKSINDTWGH
NAGDEVLRLVASRLSSATRRSERLYRFGGEEFIILLETKGRMAAESAAERIRCNLSSYEI
IISGQLVHITVTGGLTRVEAHEELHSVIARADNAMYYGKNNGRNCCVTVMADGEPSRISR
>A0A0D7M282|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSDMILARVSQSLATEQSVESLVRQLLEMLEVVTEMESTYLTKVDLDARLQHILYARNSC
QMQIPEGLSVPWDETLCKRAIEENCLYSDNVPVRWPECTTARALDITTFLSTPVHLPDGT
FYGTLCATSRRQHALSERGEQVLHLFAGLIAQSIQKESLVAQLREANAALIAHSYTDALT
GLPNRRAIFENVETLFSLARHLRQKIVVAYIDLDDFKLINDRFGHEVGDQFLIQIGHRLL
RKCSDNDILGRLGGDEFLVARLSPDDDREQRVRLQQVKHQLQQQICGDYHLGDIHLFYPG
ASLGVVEIDPLETDVNCALHLADSAMYKDKKRQDKTAFVVH
>A0A336P279|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGIIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVASRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A431SLT1|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGSLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESINLTYTAINIIEACVGAVLLRKLLPWYNPLQN
LNDWIRLALGSALVPPLVGGILVHFLVPGAEPLRNFLFWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVITLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPPSMTPSNMMVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLINGEINSYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRAHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHAIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDANYQTAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSG
IGIDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A3V8M844|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2S6E8F8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVMLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A483G4P9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A087APV3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. gallinarum|TrEMBL
MSKTIEASIVVVDDEPSIRELLVASLHFAGFEVQTAASGSEAIEVIEKAQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVSRAGQSIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIMVTDENGEQHKVAPLIETKRGIGYMIRA
PKTVQGA
>A0A0J2G8J0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGLAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A3Y6RBY0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINMVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8G9RN42|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAAT
MTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNF
ISHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTR
HLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQ
AKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGH
ATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPF
DLHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A793GSE7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLEMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6D0IQM1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A135PTU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0E1L534|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGAIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A377BPK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEV
PDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIA
QYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFI
DLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISS
LRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKT
PFVAHPALHS
>A0A1M0JPX4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8H2BHR7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLEHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A193LR78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0K3S3C4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1Q6AGW2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKLLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A379F036|diguanylate cyclase|EC 2.7.7.65|Proteus mirabilis|TrEMBL
MSELVINNNIVNDLLIKQFTNYVFMMIVTDIKGNIIYANKKYCQFNHINFESIKNKRYNL
FYLVDENQDVFSNISDNKEVIRLEAKHPNKNKQEVWEDINIVPIFDKNNLISHYAFLSLD
ITDKVKLRNDLLNKSYIDSLTGMANRLSIIEKIEQERLNIATPSSFCLGIIDCDKFKTIN
DQYGHAIGDHVLCEIAQRLLALERQQVYCGRLGGDEFAVLFPAGLRSCSLLLLEIIESLW
RGMEKPIKINKEKTIVPSISLGIAEYPKDGKTLSELLKSADKQLYAIKEKGGNKYGFYSE
Y
>A0A7B2AQE4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMASNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1Y5BUL3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1C3QAH5|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MCRSAPGVGRFGACMLLKELAVFDVLSTPIWVVHPFTECVVYANQASRTLSGDMSLNEMR
NGIYSTCPETQLQHYLRYLDAMTEIFEVWTLQTAKGLQSVYCKTTLVETEDCGPLLLFEA
VKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPQKEGLIVDANIAALRFYHY
SDEEMRNKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGSLRHVQTYAGPVVL
YNIRLMLCIIHDITEEVLLKKELEFSAAHDPLTGLLNRREFYRLVDAPSFIGHGFCLLLI
DIDHFKSINDIHGHQKGDEVLLVISRILETSVDREDKIYRWGGEEFLLFLPHSPIARALM
VAEAIRQAISEYQTLSVTVSIGVAEHHDGEAIDQLFYRVDKALYAAKNDGRNRVTRLPSE
NVAAHSGRSE
>A0A5I0ZIG2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cotham|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASLGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U2TJP4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAERLQELADRNMYQAKHRRAERSLN
>A0A5V3TPV2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A742KJT2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVPTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A753ZAD9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0D7E756|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MRGPSPLEQEVINLLADPQFEGHPLKEALSQLWGAHHDLLGRIERIARVSDGYQSIARER
ELSLSARFDKQLRQLEKVARISDRYQMMMQDLNASLREASTLDTLTGIANRRLLTERLRE
ESERAKRYGRPLALVMLDIDRFKVINDEYGHEVGDRVLIEVVRVMESEIREHDLCGRWGG
EEFLILMPESSAEMACTVMRRLGDSIAALGVRVNDDLLGVTASMGIAELRADETYSSTIN
RADIALLRAKRSGRNRCELAD
>A0A150HJF2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter venetianus|TrEMBL
MISNLYQSTSLHALFRKSQFTIFAITFVICSCTFATISMFTMETYAKQNLKLLSQTVLER
IQPAVVFKDKGAIDQILDDYTREHAIRSIHVYDPQQQLLAESTKKIANTSFLQDLLDKWF
LHDPVKLMIVHHKKKVGELVLYGSSENILHFLKTIIIGLAISMFFIVIALLWSVNLTYRQ
IMQAIKPLTHIAQLVSDQKAYNLRFPNNHIKEFQNLNTVFNELLEEIQIWNNNLQKENRQ
LSFQAHHDQLTSLPNRHYFYEELLNIFENPLFRHNSALIFIDNNKFKLINDQFGHLAGDA
VLREMAQRLKLSVRQEDFIARLGGDEFAIILHAIHHADHLKAIAEGLLASSVEPLNFNGE
IIHFGFSLGIAFSQFAENPEDLVMQADQAMYKAKNLNPHWFLYKPEI
>A0A3V5VS32|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ohio|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3A0Z4|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MFKFEQLESELQKQLSLYVPEFYRIVDVDTYEVLDYRHGEFIDINQKCYQVWNMNAPCMN
CTSRRAVKEDKPVIKLSFLDKRIFLIHSIPVEIKNRKYSIELIQDVSSSFLLHENNLQGA
DEVLSLISLFDERIMKDSSTNLFNKQYLLENLPAMMAHAKSESRPLSLAVLDVDHFKRTN
DRYGHVFGDEVILKISETLIALMNESIHAVRIGGDEFAVIFENIDPSAAMSICDQAIHLL
ASFHFESYPEYRIAISCGVADLRESDTAESFLDRADRMMYGMKHKKLCNK
>A0A1E3A794|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MNIRTSMYRIVFLMIALPFLLFSLITTYIYSSGLQNALIESLHVVATTHVTEMTDFCEQQ
KDYMTIIGTMDISRAAMKGSLDKDLCMYLDNMLYSRVESLSYLNTFALIDSDYRVVACSE
EHSTFANDGIDSLIKSMGDQDFFFSDILIDGQGNKTLVAIARIDEQGETLGYSLMEINLD
FYEGIRERAALWNDATFYLLDGRQQIISAGTSEEGRDNFVTSATERKDYIKNYESIDFVK
NPQGYFQYKVGGKGYITYYSNVKYTHWRILLTVSMDNFLSQKYVYYILAFFMISLCTILA
FRIGSFVSKRIVHPIKSISSTLTDIRESQDYSLRVSVERKDEIGRLAVEVNNLIDYIETE
SLYKAQQRRLLQQKAEQDALTKVLNKERISQYLQEALDRHCSENTEMAVLFLDIDDFKIF
NDKYGHHVGDQVLLFLTSLLTRESEGTVGRVGGDEFLVIIEKPDNVRSLDQCLRQIEEKA
GSSFVIRGSDCCLPIYCCIGAVRIDFTVMEGETLSAEKAIGLADSAMYRVKNNGKNGHLI
LEYPGSETANT
>A0A3Q9M8D7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Moero|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A822UR85|diguanylate cyclase|EC 2.7.7.65|Clostridium perfringens|TrEMBL
MLEESSLISLLDNFIQKNRESIDNNLKNLIYKDYLTGLYNRRSLIRLFDLMKSSDLLKKL
TLFVMDLDEFKIINDSFGQSIGDLVLKKVSKVLTDTCKDVYIARIAGDEFIIIYENLENI
EKIKSISNRILSQIN
>A0A5C0A7M9|diguanylate cyclase|EC 2.7.7.65|Gluconobacter thailandicus|TrEMBL
MEWQLIIDAVEPAIRLIVADIVEERAPAGVEHFYSTLLNHPEATPFLSNQIVNDHLHAAL
LKWCQSLFTPVAPDLSSLVATQRRIGLVHARIRVPLHVVMHGARLLKSTLRQSLFESLTS
STDLAKAIDYVENMMDLAIEMMSREFVRDLQKEIETDEAYRLVTLGQDVTLEREIQRAAL
LDWGHKILLAICCNAPPPLPLLEASGFGLWLNHKGSLLFPNTGGIEHIKTAIRRIDQVLI
PSLATETPPAAARIHELQAQIEEIRFLMDDLFKKSEALESGRDPLTCTLNRRFLPTIMAR
EVAQSIRRKVPFSILMIDIDYFKAINDRYGHTGGDAVLREVAEKLIASCRTSDFIFRYGG
EEFLVALVETDLQRAFQIAESIRESVTKVSTQPTGTALSVTVSIGVAHFEGHPDYTHLIE
DADRALYYAKERGRNCTVIATPDLASLPRL
>A0A517MKV6|diguanylate cyclase|EC 2.7.7.65|Roseimaritima multifibrata|TrEMBL
MPEITKEQLEFTASETTVIPDLLADLGSLAAADSLTGEASSAPEMEFENQLAMVRLGIAT
ALYYALRTKHPPTAAHSLRVAVGCSAWAEWMGVAPEVRDRIEVAALLHDIGKIGIPDSVL
RKPGKLSVREQLAMDLYPRLGCEILEGCTDDAEILGIVRYGHTWYDSRRSDDGPQRDALP
LGARMLSIVGAFDSMTTDHVYRPAISRERALTELLEGSGTQFDGELVHDYCRMLESHPAK
LQGQVMTRWLRQLKDKRDARPWSTAGRASSVSLAGDEAESQYQLFHRQLFDHMHDGVVFI
DKEGNVVEWNRALERMSGVGAEAAINHLWTPDLVGLCDSQNQLVTETQCPLLQSLKSGMY
SSRQMLMRVADGTEIPVHVHVSAVTSGVSETYGAMAVFHDASRQANLEERLVDLHEQATK
DSLTRVDNRGQFDRALIELTDLATNSGATFSLIICDIDHFKRINDVHGHQAGDEALVCFA
EVLKACTMEGDLVCRYGGEEFVVLSPGSDNPAATQRAEQIRAAIENTPIDSLNRKNMTAS
FGVTEYQAGDSPETLLARADRALLKAKDGGRNQVVQLGAGRSSDPETASGKTGRLSSWLS
WFEGGDVGNTEVRMITPVPADLAIEKLRGFIADHQATIQDVNESKVSIRMSVMFSFGGRR
RVDQRIDFDLTVQLSEEHTKRSASGGLQTSTVIDAQLRPVRGRDRRMRELTACTDRVIAS
LRSYLMATLVRP
>A0A853SBT2|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MDIKTLVLALALGNLSLCAALFFFEYERKKSLSMSTWAVAKQCQAVAWCLLYFRGVLPDF
LSILLGNSLLFAGMALDAGALWQAAGRSGWRRYVLPTLGLSVTLFAACYLLDVAPLLRSA
GGSLIVAGFFLAGVAALCLKWREASMLRRFLVVSMGLLSLLIAARGVLAAAVPDFDAELL
QLAGFGALYLMMLTNAFGYLLLSREKLGGELARLEVLDAATGVPNRRGFYQALAPWMALA
RRPGLPTALVVLNIDHFKRVNDSYGHPVGDAVLKTIVDTCRQQLRDSDLMGRLGGAEFAI
QLPRTTLADALMVAERIRAAVEALPVKTERAVLQLTASLGVTTIRAEDSTVSLFKRADEA
LQAAKQAGRNRVVEAQGASTLDI
>A0A5E4SMN5|diguanylate cyclase|EC 2.7.7.65|Pandoraea aquatica|TrEMBL
MSHTLPPRRTTDSTDSLYSSDRPAQTAHALWRTGGMSGLGGMHNAADRVDVVDAGAGTIT
SPYLPSSPGRGRIDSVTDVFDRESTWLHARSTVAAEPSAKSVPSASPFMAAASGVSLASA
VRFEHHESFEPFVQLPNSRPEPSPSTALLSSTRWALPTRRDMTASGHDSSDANDLNDARA
RLLRSAGSPLGRATGVGLDEAERLAALRRYEILDTPPEPAFDRIVRLASHVLGAPISLVS
LIDESRQWFKARRGIDASQTPRSMAFCAHAILSDDVLVVPDARADRRFADNPLVTGDPNI
RFYAGAPLRTPEGHRLGTLCVIDRRPRDLDDEKRGLLADLSALVVDELELRRVNRVLGDM
AMRDGLTGLLNRRAFLMQADRLFAVARAQQRRLAVLMLDIDHFKGINDTWGHAIGDRVIV
ELTLVLRAALRKSTVIGRLGGEEFAVLLPEADAQRALQAAERMLVAINGASVPGPNGPVR
FSASIGVASLGPDDADFGTLLQRADRALYAAKQAGRNRVAVL
>G4SX83|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MTDVLTELPNRRYAMSVLRQLWSSVDAKASILTCMMIDADGFKQINDNYGHESGDIVLQA
LARELSHSVRNDDIVCRLGGDEFIIICTDTPLNGAMYLANLVSKTVAEMRVKAGMGVWKG
SISIGVAVRDHTMKSPDSLLKAADDGVYMAKHDGRNCVRSIQVATKD
>A0A8E6KKW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000541|TrEMBL
MSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAHSLEAAL
VFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISHWLFPLP
VSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLHNGVVDA
LQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKNAQLLRT
ALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAGDRVLIE
VAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELHNGQRIT
MTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8E6NHZ2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000541|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8G4D7F3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGWLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERALSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEGNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G5UEI5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGC
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A1V5WDT4|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MKTTLRLGLQINAIDADYSRDLITGISNWCSEHDMSFILFSGRAFGWPYGYEYQNTAVYS
HIHPGSIDALILITGTQCNFIPKEAFQEYLTSLAPLPVISVSVALDGIPSIVVDNETGLR
NLVSHLIEVHGVQKIAVFKGPDDNPEAVLRLSVFLKTLEEHGIPFDASRVINGDFSIENC
HTALAEYCSRHPVDFDALVCLNDNMAIGAVKYFQEQGIRVPEDLLVTGFDDLVRSRYEEP
SLSTVSQNLVEQGRLAAEYATRVIQGKQVPSRTTLATRAVFRQSCGCVPRGNLEYTAIME
DNQKQYASPEFFINPSASWFRLQDGMYKLRQYLFRLVSLLSLSDLIEELRVNFESFDIQT
CAIVLFRKAPRNSRGERFALPAEAEIILHYDEETRGNADRNPLFFDPRKELLPAGIFSDR
PRMLIVNALYHREHQLGYIVFEQGMYDAALYETLCVQLSTSIRAALVFEEKEAAEERLNE
ALFDLERSNKKLNDISRTDELTGLYNRRGFISLGQRSIDLALRRNKNGLIMFGDMDGLKL
INDTWGHETGDRAIVAMANVLKKTFRNMDVLARLGGDEFSVVAVDINPGFLETIRSRIED
YLAEYNETSGEPFTLSISIGAVAFSGSENNRLEKLLSVADSLLYEEKRLKRESRRKAKGH
KPKS
>A0A8F9JU19|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGSKESET
AAELSASVPSVVASNTPIQPAAAAPSLPVAEHDEAPGGPPQSLPASRVAAIESAPTGWIG
VAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEPGVEPSLAVPADVESAPEAPATP
VDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERID
GSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHSGYTDVLD
NARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVSG
RLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDGG
DLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPAT
SLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRAK
RAGRDRLEVA
>A0A8G4RHU1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQXGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2D1QJY8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MSVTPSSSSNHSFILRFLFLLALPLVLTTLGSAYLFSVMQKNTLLNTMRFFNDSTGQQWD
NSLSSVERQINIIIDDIKKNDGQLPISLRTRYHDIWQYLLYPDGPIKTVYYVLKNNEQTN
FSLASMPQDINVTQRTWYQNAMEKPGTSIWSSPYIDAVQKTPVVTLSHAVLNNKGNFLGV
IGIDLNLKVFSARIGRLLESGDKVGYMLYDRGSRLVIAHSDPLENGMPLVTSWTDELKGR
NGSFMNTDGELIAYHALHNNPSWLVITVFPFTNSFLIGEMLPTTLISLILSLSIFTLVAI
IFRQRLEHTISTLVQVVRQLRVTPAGQQIVIPKLAGIEELEDEIVMISDKMQAETEKSLR
DALTGLYNRRHLEETLATLHRDNHQYILAIIDIDNFKRINDTYGHPIGDAVLKRTAQLGN
QLLEEHATLCRFGGEEFVAIFEQTDIASAQQLMELWRASMGQQDWREPGLSVSFSGGIAE
SLDTPPDSVMARADAALYQAKQTGKNRLQRA
>A0A485EME7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MPSLPTLQPLDLYRRTLACLVLAVSCLGGGGLWADDARTSVEQRSNAVSQVLLGIFSYVR
WPKEPAVLQLCVVGPTEYADGLLRGMVQANGRRVHAERRAVDNPDLGTLCNVIYLGVVDE
RERQQVFRSPGRASGPVHQRAWHRMQRRQHVLPQRRRSAHHLRGQSRLHRPQRRTRAPER
IETGKAAGHSVMNRRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYA
DPNQQLIARSISYTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGQTLASWHRES
TGPLHLLEQQLAHWLLSAPTEQPILHDGQKIGSVEVKGSGGSLLRFLLTGFAGMVLCLLL
TALGAFYLSRRLVRGIVGPLDQLAKVAHTVRRERDFEKRVPEAGIAELSQLGEDFNALLD
ELESWQARLQDENASLAHQAHHDSLTSLPNRAFFEGRLSRALRDANEHREQLAVLFIDSD
RFKEINDRLGHAAGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGADALRIA
DNIIASMQAPIRLSDGSTVSTSLTIGIALYPEHADTPAALLHDADMAMYIAKRQARGSRR
LAELNDPRILQEEKEIDSATPEAPPK
>A0A5E5QZ37|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRQNRTLDKPRLLGLVWPFIVVVLLQAMLAGGSLYVLSAVRSYVGGESLWSKGQKDAIYY
LTLYADSRADEDFRRYEEAIAIPLGDREMRLALDQPDPDIEAARQGILKGGNHADDVTAI
IWLYRNFHDFSYFERAIELWLVGDKYVMELIDVAGKMRAGIGAGQASAEQVQQWKTEIHA
INEKVTPAAKAFSDALGEGSRALLRLLLVANLTTASVLILLAFLRTRQQLMQRQEVENAL
DAERERAQITLASIGDGVITADTQGGISYLNPAAEQMTNWTLDKARGLPLASLFRIVDES
SREEGMLLIEQILSGEIDGGREHSKLVLRHDGSSVPVTLVGAPIHRGGEITGVVLVLHDM
TRERQYMARLSWQATHDALTGLTNRREFEYRLQIALERLERNSGRHALMFLDLDQFKLVN
DTCGHAAGDELLRQVCTLLQQGLREGDTLARLGGDEFGILLENCPAEKAVEIADHLRKTI
QDLHFTWSGQPFNCTVSVGLVHLLPGISTLEEALRSADMACYMAKEKGRNRVQVFHQDDV
ELSMRFGEMTWVQRIHLALEEDRFSLYAQPIVPLGEGAEEGLHVELLLRLRDEGGRLVPP
LSFIPAAERYGLMTLIDRWVVENAFRTLVERAQDPRAEPIGTCAINLSGATIGDESFLQF
LTELFARYRIPPQTICFEVTETVAVANLASAIRFINELKDTGCRFSLDDFCAGMSSFIYL
NHLPVDYLKIDGSFVKDMLEDPIDRAMVQVINHIGHVMGKRTIAEFVETVEVMEALREIG
IDYAQGLAIGAPLPFSRQPPGAGVDAQGLWPSLGQNLR
>A0A2X1WJ27|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MIISVTTYVIKINMDVKKSPISLIDVVNNKDEQSVLDFKLKCVTDECEVINSFLSLPVSS
YPYEYQEIAESIRPILHTPQGAKIGVTILTQVKDALSDNKPAQLYLLRKISTLRFLSQDL
YGMIQPSIEYLALAKEEGDPYLIAVGTVNLASIISYFEGYSTSNRLLQNLLSSHMGHSDK
WQRLKIRSLLILAENKIANGEYYKASLTLNDVIKNKPKMPYNEWDDYLIYILALKSEIAI
NLGLKDESYKLIKQAKGLLENDSHNFLVDKDIAVKSVELQWLLKNDNHIEQHIDLPELLN
RYTAATNTRYVKMLYKGLLKYYYSKENYDDYYKLRQTYEAEMEKRAGISYKLLFSNATSN
INNKSLKNNNDLYIKRFEWLTYVLLGLVLLLTFVLFKVVHLQRENVLDGLTLIGNRKKYN
NTLKEIGNRPYYLALFDIDDFKQINDHYGHDFGDLVLQEISQKIDFILPKVAQIFRIGGE
EFAIVIRHHDPLFVKREMDRVRQFIQNIKWPDESLQVTVSMGVELSVNGSDIYKLVDEKL
YLAKKLGKNRVEM
>A0A5S9Q7M0|diguanylate cyclase|EC 2.7.7.65|BD1-7 clade bacterium|TrEMBL
MSTFIDRLIARGLALLVPSILLISSYVALSYIDLLAEQWQVLVLQAGPILGLLLASALSI
QFSRTGYFFALLFVIVASIASDAGLGVVIPYQTPIYVVLFINLLIFSGLEDRGLFSVHGI
LRLAVLGLETVLGVYFMEHQQQFIDYFVALYPSIEALSPLTYSLGGLPWIIGVSVVAVCI
QLLCLLFSNQVNQPIFLITQVVLLLMISGVQSDLWVPLLLIVFSMAVCFSVLRQSHDMAY
RDELTALPSRRALNQLLLRVGRRYTVAMMDIDHFKKFNDTHGHDIGDEVLRMVASKIARV
GGGGKPHRYGGEEFTIVFSGKSPAQVESHLEALRETIANYSMVVRSKRAKENTKKTKSDA
KKGRRPNKDMSQYKTLSVTVSIGVAERTGTLKTTTQVVKAADEALYRAKKAGRNCLQY
>A0A157P7T3|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MLDPILAQLSVSMPNAKSLEDLTRPLLEMLGAVTGLESTYLTSIDLEKSEQHIRYARNAG
EMNIPEGLTVPWSDTLCRRALEEGRMYTDDVGSCWGDSDAARQLGIQTYVSAPVRAGDGA
LLGTLCGASAGQQPLRPDAETVLRLFSNIVAGYIERERLMDNLKNANSQLHAYAMTDTLT
GLPNRRSLFESLQTLLAKGVNHGNSVLVGVIDLDGFKAINDNYGHQCGDQFLQQIAKTLS
AALGPDDVLGRIGGDEFVVAGPGPAIAGSDSQPGRIIDNGGPQAAARLLQDRIGTATIGD
ATNWASAGWTTAAPAPASWRSNPPTWARMPPCGWPIH
>A0A6N2YIB3|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MTAQSWRSHYEQKYQYSLRLFLLLNLVSSFLSLVSPLFTVITFTPPCFLIVACSAVLLLW
HWKFAQHKINIPLIALIFGLLWAWHVALKAMVMGPPHFNYLVIALLSVLFIGTIAFSSNI
IAFTLHSLPTYVTCLFLGGGEQWLRMSWCFVLPIAGIALQSLMQKRSDVFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTILSLDSSEHYVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTSSSAENALQAAERIRQRVYDLKIPHM
FNESVATNVTISIGMTPLVDADIDSALKRADNALYEAKNMGRNIILAS
>A0A157SLJ1|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MQGLNEYAARDSLREQARLDALTDLQVLDGGPDPVFERISRLARATLRFPIAYVSMVGLH
HEILKTRATHPVSTGSRDTAFASYALQSAEPMLVSDTLEDPRFCRFPQVAGAPYVRACWS
VPLATRDGLLVGALTLLDHVPRQAVRDDLSILKDFGKLAAESMELRAQSTTDVLTGVQSR
RAFLSEGERIFLSRHPDRQALSCVILDLDDFRRLNDALGHDAGDDALRQIGGLLRSGVRP
DTPIGRVGGEEFAILLPGESLYGAHTVSERLRHALARLSDQGFPGLSASCGLAERNSTDR
CFMDLLDRASQQAYVARHAGRNCTRPDLAHISGHAPGFRHRTPI
>A0A8E6VXY8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 6,7:m,t:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWVALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7X0DLH9|diguanylate cyclase|EC 2.7.7.65|Novispirillum itersonii|TrEMBL
MIHLAKALIAIGESEAAEALSRALSAQGYTCTHTADGAAVDELVVTHSPDVLIIGPGLSG
IDQKELAGHLKAAPATRGIPLFYLSADPLDQTGDGLLDLGIDDAVHWPGTPDLVLARLRP
LARVATMRTEYMARRAVMDAESLSPEIPEAVISDSPPSILVIGGDDTVQAVTHALTDAQV
MVAADLIEAQQLMDERLFDAAVMAPGGNPQPYLDLCLQIRRNVRLFNLPVVFVSPADGAD
DLNTAMSMGASSALRADAGVAELRFTLRVLVRRQRLRWALRRCLGGQLTPATVDPVIPGV
YSQAFLDLCLSARLSGAETRIRRFSVIEFAFAGVESIRHEFGEESELSLISQIGQWLTLL
VRAEDMVASLGGSRFAVVLPDTPLSEAQVVMHRIAGVISNTEFAAKDVYRVVTVWPFVNA
AEVVAGDTPASLLARATAVVGEDMAPW
>A0A1Z1VVS5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri Y|TrEMBL
MFALADVNSFYASCEKVFRPDLRGKPVVVLSNNDGCVIARSAEAKRLGIKMGTPWFQLKE
AQFPEKLYVFSSNYELYASLSNRVVALLEELSPRVEQYSIDECFLDARGISHCMDLEDFG
RQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEWPQFSGVLALSPENPRRTAKLLSLQ
PVEEIWGVGNRIAKKLHVMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISLEE
APPPKQQIVCSRSFGQRITTYGEMRQAVCQYAERAAEKLRGERQYCRHISTFIKTSPFAV
NEPYYGNVATEKLNTPTRDTRDIIAAAVRSLDRIWLDGHRYAKAGIMLNDFSPNGVAQLN
LFDDVQPRPHSDALMKVLDGINHSGLGKVWFAGRGIAPDWQMKREMLSPAYTTRWKELPV
ARF
>A0A2M9MYI5|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM2FR|TrEMBL
MGTPYSAMITLIVTAGVLNIIMGLYALSGRSKLAMVKPFFVFSMLASIYTFGAALELSSN
SLHEIQFWIKFEYLGMPFLPPLNLLIILSYLGMERYLRRPLLIGMFAIPVVTMLLVMTNE
MHHLYYRDIGLHSGISSLKVDVVAGPWYIIQGAYTFACMIGGVILLLRSWHKMPSYRFQL
NTMLIGLVLPLIGDFLYLGGLTPDGMDPIPVIMTLTSALYLWALTSKGLFHVAPIARDNL
FSSMREGVLVLDLDNRLVDFNPAAAVMMPELSPSAIGGPLLELWHLHTTEPIFGMEQREG
WDAGESDIQEMRWQLGDQSFNYQIRSSVVRNQGGREVGRLIVLIDVTERTRLQEELRQGA
YYDGLTRIYNRAHFMKLSCTLLSQAVRSREPMAILLFDIDHFKRINDVYGHDMGDQALLH
IVELSRQSLRSEDLFARYGGEEFVIAMPGRTTTEAEAAAQRIRAELRTQPMATPQGPLFI
TASFGIASIGASFYNSTIEVDAEEVKWDAELKRLLKLADRALYEAKHSGRNTIRVSDEEC
>A0A4V2BUT0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. MEBiC 03485|TrEMBL
MEVYSLVMYQNTGQGISSLSNTQLEDVIGEIEQAIEWHQSWYRNLLRSLIADIPADDQDL
SDNAHNLCRFGQWFNKLPEQTLNLHPYFSEIASAHQKMHQGAKVLSSLKESNSAIPVNLL
DQFHTDLDSLRDYFEAINDELYELLHTRDPLTGATNRANLVENLQKEQELCKRKSLSCAL
IMIDLDHFKRVNDEFGHGAGDKVLIALVKCIKSHLREYDQLYRYGGEEFLVCLPHTELEG
AKSFSERLRAAVATLKIEIGNDKHINVTGSFGVALINANDDIETAIERADQAMYQAKKSG
RNRVCTV
>A0A7H4P6F6|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MILSNPGMYIDLLALLFLLFMLWSSTKVRMNHVAVNWVRYGLLLWIAGGTFDLMDEIFRQ
PRWMGYYCEDLLRLTGMLLSAVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTV
REKAGNTQALMIVDIDYFKKINDTYGHLVGDEVLFALGKQLAKLTSDKVLPSRIGGEEFA
IIVDGLSAQEVDELAQSILQNARAILINHDNPLSISIGVGLRHKDEPQNQFIKKVDDALY
KAKNNGRGRVEWGRVNYPCCALRQWRRYSDGERSV
>A0A807LJ26|diguanylate cyclase|EC 2.7.7.65|Kosakonia cowanii JCM 10956 = DSM 18146|TrEMBL
METYLKSMKGEWLTLLEKTDHNIRRLTAEVAHTHAHDLSETFYRIVLTDPHAREFLSNAQ
VEIHLKSALERWIKEVLACTPDDIERLIQQQHTVAEVHARIGISVELVEMGFRVLKKIFY
PVIIESEFSAEEKLQIYHHAINSIDLAMEVMSRAFSFSEHNSAKEDENYRIFSLMENAEE
EKERQTAALLSWEIDLIYKIIMDADLGNTLAVSQSDFGLWFNHKGRHYFSGIAEVGHISR
LLQELDEIFRSTRATPRALSNRALRVGFLISVRKNVVQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFMPTIFKREISHAQRASTPLSVLIIDVDKFKQINDSWGHPMGDEILRKVSNAF
YDNVRSSDYVFRYGGDEFVILLTEATEFDTHRIGERIRSRVEKTIIKTPEGERVPISLSI
GAAMFDGHPDYERFIQRADEALYIAKERGRNCVHIWQAAE
>S0G5S5|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MIPNKTTRILIVDDEKMNLKVLTELLREDYTLVLAKNGEQALKFARQKPLPDLILLDVVM
PEMGGHDVIRQLKEDPLTKEIPVIFVTALSSTGDEEQGLKLGAVDYITKPFSPPIVKMRI
HNHIRFVHHHRLLDRLAYLDPLTEIANRRRFDQVLVKELSRAARNCTSLSVGMVDVDFFK
QYNDQYGHAMGDRALYQIASSLKASLERPGDLVARYGGEEFALILPETDAPAAGRVAEKA
RRAVENEKIPHTISSVSSHITVSAGTATVRFTGRAGEQLRETRDGQTCEHTVESLMLQAD
QHLYKAKQNGRNQVWP
>A0A0M7JA93|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSRAVPSSTDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVSTRLHKGMKGWLRGLLCVREQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLISLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALGQIIEAVARLDDVVLPRLLQGGPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATREHSTFSVLLLDIDHFKAINDSHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTAREAALAAAEKLGAEIRRHAF
AIPEAGSLRITASIGVATFDGHPDYAYLIDRADKALYQAKQAGRDRSVAG
>A0A171KNL8|diguanylate cyclase|EC 2.7.7.65|Kerstersia gyiorum|TrEMBL
MLRKNTSPEEWVADWRRICGRYGEDIWVLVQGIVREHKAFLATRFYEQMMQDAAASFFLS
AQLVQNRLHPALQAWLEGVFSVALNGDYEGTVAYQKRVGGVHARIGIPTHLVMRGTRALN
EAIFARLQDVDVVQRTNAVAYVAELTSLAMEVMCQSYAVSHDRNSRAEEAYRLFAISQDI
GAEREKQRAALLGWENQFMYEVAVNQARANLPLLGKSEFGLWFTHKAAHAFEGSADVASI
LAEIDRVDAAASQLGSMAGSSEGKDAGQVEVLRRIRDHCRTVGFLLEGLFQQAGYLESGR
DVLTRLLNRKYLQVIMNREIEFARTNGCGLAVLMVDIDHFKRINDEYGHDGGDAALRHVG
LFMSQTVRSSDYLFRLGGEEFLVVLVDVEPETAMLVAENLRRRAENERIPLGQDIHLNMT
LSIGVALYAGHPDYLLLLKAADQALYRAKHLGRNRVELSRGLE
>A0A7U1KX40|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1L8CK97|diguanylate cyclase|EC 2.7.7.65|Mariprofundus micogutta|TrEMBL
MKLKAKVNRLTIFATVVLAVLVSSVVSVLIRDYAEEQARNEGLIVVEMAKIGLLHSMQEG
VAFANDKEHVRNEINLMFQEFASLPELIEMRALRGESVTRQYGQVAGRGEIEEVERQMLA
SGEASETIEINERGIKVFHYNGPLIASSRNRLNCMTCHDAAEGEVLGGLSVQVDLTKAEN
AISSAIYQLVALLLLVGVLFAFALRKLFMPMVMVINQITGAFHRAHNGDFTHRINYRSDD
EIGSIADATNELMESLSENVGAIARDVEALTGRGNQGTNVKPMQHMANVVHNLTTAVRFK
EEIEADRDLDEVYAHIQRVLVNDFDIDKFTMYEVSSQRNSSIPVLSAGLPEGFDSWCSKE
VQGDADACRAKRSVRTVDSRSDSEICLPFCADCKESCATLRHICLPVLNSEGDGVTLQLV
FDLDQQGEIEKKVSLLQYYLRVAAPEIEAKRLMRSLKETALRDALTNMYNRRFLEDYANS
MESSVTRRGSTVGVLMCDIDLFKQVNDKRGHASGDMVLVETASILVETLRASDLVVRYGG
EEIVVLLMDTDDQRSMEVAERIRSNIESYVMRDEQGSFGITMSIGLSMYPENGSTLNECI
KNADSALYKAKETGRNRVICHK
>A0A8E2TD76|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A7G6KEB0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A8I0FPB6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. C1|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIHHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A2X2JI87|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIVAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A8H9AAZ6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A2T0BIH1|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MKQYGHVYNDFDEMKAFINTMVISKTDSILIQIMTGIIEVEFAIKLIDELIILLPKAEII
GTTSSGEIYEGNVYTDSAILSFTIFEKSKVKTALINNETTEYELGLYIAREFVEEDTKLM
IMFSDGLLTSGDNILKGIHSINSNVIICGGKAGDNDSFKETFVFTKEGITNKGVVVAFIS
GDQLNVTTDSSFCWSSIGKEMTITKAYNNTIFTIDNIKAIDIFKKYLGEDAVKNLLMYAT
GIPLIIKKHDMEIARIVYQCNYDGSISFFGNVEIGDKVQFGYVDITSLTVKPLEIFNNLK
QKSLEAIFVYSCSVRRALLKEGAALEIAPLAKIAPTFGFFTYGEFFSTNCSNELLNLTMT
ILGLSECGEFCKTSTVELDNNENLNKHFFEHKELVSKKMFIHLVDEVTKELKEANEILEE
QKNKIEEIKNITNSIMDINMQLLSSGEFDSLLQMILDKALEIISVANMGSILLMENDMLH
YKATKGYLLDKIEKATYKIENMAQYTPSGKYGLYNPIIITDIENYPLGSKESHRKWRNII
SEEPSEILSCVIENDGKIMGILNIFSTSDHAKFNEDDKAMIRHLANDISIAYKYSKLLED
TLYMSRYDGLTQVLNRHYFRIKLDQVIHKAKALHENIIICELDLNNLKVTNDTFGHESGD
ESIKYLTDVFKTRIETNNIMGRTGGDEFELIFTNKTKSQVIALIDHIYDICKNNPIYFNG
QPIEISFAYGLAELYVDSEDIGELLKLADNRMYEKKRLMKKL
>A0A8B4MSL7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKSQEELCANLNLLFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMILQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A823BAJ4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEVLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
SDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8H9E2S3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIAPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7Z8A3U8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDSLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A0R3JY95|diguanylate cyclase|EC 2.7.7.65|Caloramator mitchellensis|TrEMBL
MKRINIGSLRIVLVYVIISFIWILYSDALIMNNQNNLTYIKGISVFKGFIFVLTTAVLLY
VLIKKETERRIKLWKYYATYDIMTGVYNRRTGLDLLEKLFTKYKKEDRDLTIIYADIDNL
KQVNDTLGHSEGDRLIINISNILKKNIRNTDYIIRLGGDEFLIVLPDCDMNKAQKIVNRI
NDGLAELNLIFSRYEHKVSFGFATIEELYNNADEMVACADIKMYENKKINKQLNCRLA
>A0A8B4SUQ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRSGPAAVARVTLLPALLIIVAVAVGCALVSPPVGTRHEILNNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNCVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHAL
AQAILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
SAGAAG
>A0A3D1C217|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A1V5UAX6|diguanylate cyclase|EC 2.7.7.65|Candidatus Dependentiae bacterium ADurb.Bin246|TrEMBL
MKNFLSQLNDIEYNEAISNQLDTPEKLIQLLLKRVHPKNVEVIIDILKQAIIPSISSDLN
NIADVLFEQLKKNPKDIFEKSVQIQIEKLIFERFEKDKKLVIQKTEDISKLVVLMEEYFN
EAIFSSGNGSKKVLNIKEKIQAINLTNGGIEVLSKLQNELVVAASSIEQEINSVTNKLEN
GKSKIEELEEKINSLENELNKTKQENRKDFLTQVLTRKAFNEEMVKVENSYSRLKTQYAV
IFFDIDHFKKVNDTYGHECGDVVLSTFGKILEKSIRDIDLVARYGGEEFIAIIHFNLDRE
LLMLLKRIKSIVTENSFIYQDKKLKITFSAGVTIRNKYPTYDIALQKADSLLYKAKDSGR
NKILLDNGIEI
>A0A2X3KFM8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLQGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A3D1C3X2|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A486U1U9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MFTLFQLLSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIR
DPLTRLYNRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAAS
VLESHSRVDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGV
YTTHDNSVTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A486S1U8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLKNFPDEKYISDRNASFIKRVYFLRQLGVVLCFIPIYSVLQEQSHKKITIALLILNALI
WPSVAYLASMMSKDMLNTEKKNMILDSFWAGIWIGLMQVSPIPSLFIVSVQIADRYAAGG
WKILKPALTWMLTSFLIVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLRVVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRCFEQNMESAFRTTRKKKILSYILLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECSGENDIPARFGGDELAVIVNNSNDELVLTQVNLIQKQINNL
SLPSHKDFSCTVSIGISCAKNKASIIEWLKDADEMLYNVKRNGKNGYCMEVNKD
>A0A377TGA6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAAYDSLTDIYNRSKFMSLFNEIKVDSEKYQSPLSLAVIDIDYFKSYNDDFGHQEGDLAL
KIVATSLTNSLTEKGILARFGGEEFIVLLPNTTESECVAKCEVLRKCVQGILTLKRTITI
SIGAVSIYPNEGCNISFDELFKIADTKLYDAKKSGRNRVKNHRID
>A0A377TT00|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNLRIFWLTARYVMSKLMPGRWCCIIFD
>A0A377YIG0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSPERRRSRDGAA
>A0A486NKK8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGATWFTRQTQRKNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A3S4I2E6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGVRNLLCCWSTPVKK
KRKRFAERIRLAVSAGESHLPERMTISMGVYTIYDNSVTAEACVQRADEAMYEAKNNGRN
QVIVWHQQGR
>A0A378HA89|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKSEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKIQHRFFCRDY
>A0A377VZ30|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLTLAEYALLTAQRRHEPVSLAFVDL
DRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILARQGGDEFIILFANTSRHDAATAM
ETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHPSLNALVATADRLMYQAKQKQGRERR
>A0A486TPU2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLREKDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A6C8GQH5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Adelaide str. A4-669|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X3INV6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDSVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A7Z9DNB5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLI
DPS
>A0A1V5UBW7|diguanylate cyclase|EC 2.7.7.65|Candidatus Dependentiae bacterium ADurb.Bin246|TrEMBL
MNYANSIKDDIENLKIEHRGNKASKYVTISLGVVCKNAIEINSSKEIYKKADDNLYEAKR
SGRNCVVIK
>A0A2L1BY06|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTIYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHQQGR
>M1WLX4|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MRLEDIPGGLIILFLSGKIAVCNQAGATLLGRSQEELSGMGLDELFLQAEDFPPLLEELS
KGKSLEDREVCFQHTEKSEHWLRLNARPGVYEGEAAALLSIFDISSHKKTHEQLQLTREE
LRQTLRHHAIDLEQSREAVQALDCELSQKNCELDKATREKEGKFRALFNNSHAVMLLLDA
ETGEIKDANPAASEYYGYSLDELTTMTIAEINSLSPEEFREEKERAEKRQHHNSFFSHKL
ASGEIRRVEVFSGPVEYGETSLTYSIVHDITDRRQAEEQLLRFKRIIASTPDLIALVDRQ
YYNRLANDSYLKALGKPIEQVVDKPMEDVLGTDYFKNELKPYLDKAFNGEVVQKESVITT
HVNTRMHLSITYHPVCNANGSIDFVSITASNITERKRHEEKLKIFSERLALATDAGKIGI
WEWNAQDGSILWDKMMMHLYQTDKKKFAGTFDSWMGYIGKEDVEPLRKQLMECFEKETPF
DAEFRIVWPDGEIRHVKAAALVKTQSGMSKRMIGVNWDVTTKRRLEEKLRHIATTDSLTG
ANNRRSFMERAHEEIARSKRYGTPLALLSLDIDLFKRVNDTYGHPVGDMVLRSLVKVCRE
TLRETDIFSRMGGEEFSAILPETDLDSARATAERLREAVEADMVHAGADTVRYTISIGVS
ILQGEKDLLDRLMRRADKALYRAKEFGRNRVEEE
>A0A862ZJP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVILLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2N9LQH1|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MEFRRIPGMLVPLAVACLAARAQGPPRETPRMLTTAQEVHSLTPEKAARAYPVCLHAVVT
YYDPYIDTRHGALFVHDASGDVFISVPARPILPLKAGALVAINGVTGPGDYAPIVERASV
RVIGQSHLPPNPPQGTLAQMLTGAMDAQWVQVEGRVRSAHLGTNNVVLEIATDGGTLSAI
STREGSADYEALVDSLVRIRGNAAPVFNQRRQMVGVHMFFPSLHEVRVIQAAPLDPFAVP
AVPVSQLFRYSQDPGLLHRVHVRGSVTLDWPGSMLCIEDGKDGICIQTAQATPVATGSLV
DVVGFPAISQFKPTLEDATIRETGGPVWPVPPVSITADQAIRGNLDGRLVRIDAELIGQD
LTSAEPTLMLRTGRFLIPVMLPKDAAAGAAMRWKDGSILRMTGVCIVRVDSLRTNLGEGA
VRPGSVDILLRSVDDIAVLRAPSWWTPEHTLESFGATGMLVLAALGWIVFLRHRVRQQTR
ALRESEERLRHLSEHDALTGLPNRILLNDRLQIAQARAARFQTCLGLLMVDVDGFKEVNG
ALGHQAGDNLLRELAGSLGGCVRSTDTVARIGGDEFVVLLPDLRIPVEAEMIAAKIVAAA
SGPMAIDEAQTAITVSIGVVTDRDGSCDEQALMEHADQAMYAAKKRGKNGFQVYSPGLAE
DRGGGERALRGAPGVTLSTGRA
>W6KAD3|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MAEITAAQGIAATLATDERRRRDPPGNPYGRATAEADLAVPDIDEVRVEASVLGIPAEEL
TPEVVVAIRKLMEEAETLRRELAATRRHESHLGKLADNHSYLPLYNRRAFLREMSKALVR
SEHARVNCTFLYLHLANLQEIRKVHGRAAGDQAMVHAAWILRNDLRDSDLLGSMDGYDFV
ILLMLTGGQVAEDKARGLVEAVESQPFRWLETHIPLRMKCGLHQFSAGETVDQVIDAAES
ALRRNELRR
>A0A8G1LWX4|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MADRYILVVDDQMNNIETLGEVLGDEHDIHFALSAQQALVQISQQMPELILLDIMMPDMD
GFQLCEILKAKVETRDIPIIFITSLSTPAQETRGLEAGAVDYIVKPFNASIVRARVHNHL
ELKRTKDLLRVLSQTDALTGLANRRRLFEHLDAVQDKALRLDQPLSVLLIDVDSFKPYND
LYGHIAGDVCLQRVAGMIQSSLRSVTDMGARYGGEEFCCVLENADQELALQIAERIRANI
EALHIPHLHSMVLPIVTVSVGVASSTSSNRSLHANLLMAADKALYVAKDKGRNKVIVL
>A0A8G1GP98|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MPDSSTAITQLDQWIKEARSWFVPDCAKTIEILQPACQLAHDIGDSAREVQALLLISKSQ
WALGQLIAGNQTIEQAEPLVRELKDPRLQAEFENARADLLLANSQYSQALKAWSICLKQA
LSIHAYHLYVEACLGIGNIFTAQNKHGDALQWHETALEFAKKTTDHELLAESFLHVAADL
IHLKEYELTLELSKMGEPVFLTSQHKAWLADWYSYRGEAYFELGKHTEAQAWLHAAWDLN
QNLDYLWSQSINLMALGRVYIAQRRMDEAKDYLLRALQTIKTFGAHTLLLRVYALLADLG
EAKQDYKMAWEFRRQYHELAIQDAQQLAKEKLTNALERRIKDLDSQLFVLQTRQENILLR
QQNSADTELLQTLRNATLQDPLTGASNRRHLDQEMPLMYQRCNEENRPLTILMVDLDHFK
RVNDRFGHPIGDDVIRSTAAILLQSCRGGDLVARFGGEEFALLLPGAAGTTAVDVAERIR
KRIETFDWQQFHPDLKVTSSIGVAEMNQEANAAELLNCADQALYQAKDKGRNRVEFFNDN
R
>A0A149VYU6|diguanylate cyclase|EC 2.7.7.65|Ferrovum myxofaciens|TrEMBL
MLDSKPFSGCTEQEYNLSLLPKTCPPQEYIMASEPTPAELAGKTLKALVARKLSPTPENY
ARLYAEISGKEIFRPVVPPSGPVAEPAEVRPSLAWGGLIRELLRQIDLPHKGMTLSRKKE
GVNTVLARFGNDSELLYEKLQGLMRSWGSGVVSSGEAPESIENNSPVSPVVSSGPVQPVA
SGMDTAIDPVVMAHLRDLLAQTLESNKLLQPELGEEINILVTQIRAAVNGDQVTDVAKKL
RHFWVKMELRGGDKVKIQEGLLSLLRLLVENVGELVADDKWLHGQISILRDIMEQPLDKR
SIADAEKNLREALVKQSSLKQSLADAKDTLKILMTSFIDRMGEMTESTGDYQAKIEGYNL
KIGLADNLTELGHILEDLMQDTRVIQASTLRSHEELMVARRQAVEAQEKIRLLEQELEQV
SELVREDQLTGALNRRGMEDVLQREITRSNRTQSPLCISLLDIDNFKLFNDLLGHKAGDL
ALMHVSETIKTALRPTDAVARYGGEEFLVVLPATHINEATDILQRLQRLLAQKLFVYDGE
EIIITFSAGVAIRGLNETAEEAIGRADQAMYQAKAAGKNRVVKAES
>A0A6B8N6Y4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MKYRFGNRWSVFLLAFTLFSLAVGLIESIDRSQKNFLRDSLLDRAKEELSIVRSELESAI
VYDIFAVNDISALVASNPSFEYSGWDLLASSIMRKASHVTIIGLAPDDVIKYIYPLEGNE
KALGLDYRTVPSQWRTIKKAREVQEIFIAGPVNLVQGGRALVARIPIFTDPLYNRDYWGV
CSVVISLETLFIDAGAEEFSFKYNLAMRGINSSGLDGEVFYGSQSTFDNAFATETVHFPY
GSWIIAASTKDDLLRHSEWYRVHAVRLLGYPMVLVLLIAFVTIFRLYQAADRRSLHDELT
SLPNRRYFMYTLQGHFDAVSHSGKGEVFAILNVDLDKFKQINDTYGHAAGDKVLIAVAER
IKSVLRASDVVARIGGDEFLIMLPRISSIEDVDVLNIELQKAICHTPVIFEQHLINIHVS
VGFALYSADFKDVDDMLKLADVRMYEEKRRQAQRSGL
>A0A1V5UE22|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin243|TrEMBL
MPETDAAGAKVLAERLRKRIEAYEFPGQEKPLHVTISIGVSIFPDDATEKLMLIKKADDA
LYRAKEAGRNNTQIYSEAPAPQETEKKIEQKPAGH
>A0A4U9HS98|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MSDLDRFKRINDNYGHLQGDKVLQFVSRLLMDSVRPQDIAARIGGEEFVLLLNQTSSEAA
LQIAERIRLKLSSVDSASSGGQLPEPITISMGVFTATSTNTSAETCVECADKAMYEAKET
GRNRVVVFR
>A0A2M9TCX8|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. 141|TrEMBL
MRYKDKHQLAAEWLTLLERTPVALRQAVEQLAHARRAPFAEHFYRVMLDDPHASLFLSNE
QVEKRLHPSMQRWLSAMFAVEHADLEALVEHQEKIGQIHARIDIPINLVLSGARQLKQVF
YEQINRSIQAPLSAGEAAVYVSDHIDMAMEIMSHAYSVANNRHARTEEAYKLFSLTQSIG
DERERQRAALLNWENALMFAVAAQQETSALPRLASSEFGLWYLHKACHTFEGAPEIAVIS
RHIHLVDDQWMAQLTDGDSALRLAALSHIRDAARTILMLLDDILDRASGLDAGRDSLTRL
LNRKFLSVVLNREIELARRSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIILVDTDPDGSRLFAERLRQAVAKEPMLAAADTLLSVTVSVGLT
LHDGHPDYQHSMQRADQALYQAKRSGRNRVVVQ
>A0A6B8NAT0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MRFCLILLAVFLTSLSHAHAKDKDVLIVHSYHPGFFWTDAFQYGLEDILRGESITTRVVY
LDSKRLQNPAYLEQLYKLYQTKFSQETFSAIVVSDNNALNLMQRLAPEIGETPVIFGGIN
NYNPQMHSQLRATGVVEDIDIYSNVTLIERVQPEVETIYILSDHSVTGEAVRRQVEQFLT
LNTEYQTMVEQLAPETYQQLIEFTSSLDKSSAVLFWVYYRDKNGRVATEDEWEQLNQESK
SPIYMVHDLGLGHGAVGGVILSGRTQGQQAAQQLLKVLNSTSKTLPKVEAGIPEIKLDYQ
AVVRWGLGIEGEAISTLFNKPQPFTVRFQKELRAVASLVVLLSVIIVVLVYYLSRMKKSE
TLAKESQTLIEMVFDQSYHFIGLLDAQGRTVSSNSKLQELFYHQDFSVDRPIWQHQHWED
QAAQQLKSYFNTDKSEQNTQFEAEIWHSEQGSIVLEISLKPLPKTGQGADFLLEARDITS
RKITEARLYQREANLSHYYDQQPVMMITLDDHNCIQQVNHFAEQLLGYTSNQVLGHSLGE
FYSHQDAVTPRQVLLQPKQAMRGVWRREIEYRHADGRAVWVRENIRPLVESGHLLIVGED
ITETKKLAEQLEYQARHDLLTGTFNRNHFEMELAKSLLEVESYTRTHAMLYLDLDQLKVL
NDTAGHEAGDTAIQFCASMLEEVLPYNAILARMGGDEFAVLLKDCTERDAKNVANTIVMT
LSEQPFVWDDIRLNMTCSIGIRLIDHTADSPQMVHAQADTACHAAKEEGRNRYNLYCQDD
ADLQRREQEMECVSLVHNALANDRIELFAQQILALSQDDAPMHFEILIRIRNAEGEYISP
GIFMPASERYNIAQLLDKQVVTQTLDWLAANPEALANLGMCSINLSGHSMGNKEFIAFLL
DTLQHSPVPCEKICLEITETAAMSNMNQAIELFSQFKRLGCKIALDDFGSGLSSFGYLKK
LPVDIVKIDGLFVRDIDVNEVDHLMVRSINDLAKQMGKQTVAEFVENSRIIDLLVELGVD
YAQGYVIGKPKPLEELVDELLTDKRSVG
>A0A1C6K0N6|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MKRPAPSTTAQKKQDLREHMAQRVLRYLWWILLLVAGIQLFNILHALVYTGWRLHTPASR
VYVLLYACLLVVSLLGLACVPFLKRSLPHSAGLTLWLQWIYCGFLLCWAVMVTLYDQRVG
PGAETYLTVLLTVAVLAELPPVPAAVLLGVPQIALMLALPYYQPTKQDNFGLYLNSTVLA
AVAIFIACYRYLSQKRQHEGAQLILEKNREIAEKNRELIYLVGHDSLTGLYNRRFLDLRL
PAICADCAEHGKHLGMMMIDIDDFKLYNDQFGHQMGDACLDQVSQALLGCLQSEGEYILR
YGGEEFLYLGSGADTAAVRRRGEEMCAAVRALALHAAGKPSPVTVSIGACAAVPQDKSAW
QTLIRRADQALYTAKHQGKDQVVCDTVEGR
>A0A5B7XVD6|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNDENFYTKAYAREGINQARSADEHHREGIRLARRLRLPRAVGLAILFFPIGSMLAALPA
NGLWWLLLVGWAFVWPHLAWQLAMRSADPHHNEMFNLKIDAIMAGVWIGLMGFNAMPSAA
LIMMMSMNLMGVGGIRLYATGALMTALSALVTLQMMHVPLAFVSAPLEIWLALPVIVGYP
MLFAWVSFHTTNSLVEHKRRLELMSTLDGMTGVFNRRHWEVLLRTEFENCRRYHRSATML
LIDIDHFKGINDTWGHDVGDQAIIAVTRQLQLTLRASDMIGRFGGDEFAVIMSGTPAESA
IAAMSRVHERLAELRLPGAPQVKLCISVGVAPLTTSMVHYQEWLKAADIALYKAKNAGRN
RTEVAA
>A0A011QKD0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MFKHDQSSPLQSSRHASRRSHRLPDLANMPLSLLAHAPRPTTNGRVHHPHIRRVEPPATA
TSALELLAAEARIAELENALSEARQAAFTDPLTGALNRRGFEETYQRELARSRRNGSQLA
IALIDLDNFKHLNDTLGHQMGDEALVHLVKSLRAALRPSDILCRFGGEEFVLLLPETTLD
EAVAAIVRFQRQFAASAMPGCELAVTFSAGVVAKQISESVEDTILRADAATYAAKRAGKN
CVVRG
>A0A8G2E852|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MSSLSIRLFTLFREEHPVRDALVLFTITLLLHFFGAMLRLVQELSFFWPLNAVMVGIFAR
YVWLNRSYFYATCFVAMMVYDGLTSRWGMGFASLLINFSNIVFIVSLAQLLLWDKRRTDS
MPGPINVLNLFCYCLLAAFLSAAVGTLGSMDVERETFISLLADWFSEQFSTAVLILPFIM
TVTIPSTLSGFRWSQLLPVMVLVLSIILGVAVGGAESITFPLPALIWCAIRYPLPLTCLL
TFLTGIGEILLVANALIHLSPDAHLQPWQLFSTRLGIAAMLISPVIVASSVDAINNLVKQ
LALRADFDFQTRVYSRSGLSEALKRQPQSATQQLTVMLLDIDGFKRVNDSWGHECGDCVL
AQFAQRVRDLVGEQGLVARIGGEEFAVAMLSATPQEGQLLAEKIRQGVAAQTFVWGPHKI
KLTLSMGLECRPVGGGRITELFNQLLMAADDYLINAKQAGRNRICTPTLAENQ
>A0A2U3K269|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MNQHSPPRRYLVAALLLLAVQALASALLAPGFARTAVTDISGALLMLAALLAFATNGYAS
SGRMRWLWALQAAGWALWLADQAVWIMFDVVWRQKMPAMQFADALLFLAGAPMFAGVLLR
PHREPSERSARLGAADFLLLLLWWLFLYISFVVCWQYIVPNEDAYNRNFDLLATAENMLL
TCILAVFWWQTSGRWKKFYGLFSGAVACNAVAFYLINRAIEQNVYFTGDWHDLFYSASFA
VYPAVALAGEGLSPTQKAESGDGSWLANWAMIAVLSLPVIACWALLDPRLPRLAAHFRVL
VALATMFLMVLLLFIQHQRLNRELRHTNVVLHEASLTDPLTGLRNRRYFSATIDADVSQA
LRAHADGHDLHIRDLVFYLIDADDFKEVNDRYGHDVGDRVLVEMTRRVSSSIRDSDVLVR
WGGEEFLLISRHTDRREAELLAKRVLAAVADMPFNVDEEGGTIYRNCSVGWAAFPWFPDN
PRAISYREVLTLADRGLHQAKVSGKNRAVGMLPPTGKVIPISVEGLHAARMQVDVLAVSG
PSRQP
>A0A6N3DM86|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MKKKIKIQNTIYWSIVVTLIFTALFIFICIFNQKQFHSFQESSQQYVLCKDSVEQLEEGC
DYLVEQARLYAMTGNEYYMDLYFREAHMTRRREHALKQLEEYFDGTQTFTSLKSALKSSG
DLMSIDYYSMRLIADANGISEDSLQQEVANVKLTDEDVLLSSEEKLKKASSILCDNTYQA
LLVQTKANLANCTQSLLDYTQKKQNRAQAIFFDSFRNLKISTFLMVFLMLAFCFTIRHLI
VKPLISYNECIRLGEIFPVLGAVELQNLAITYNQVYRENQQTQQLIRHQAEYDALTDCFN
RRSFNKFLSLYETDAENHPFALILIDIDVFKSVNDTYGHAIGDVILKKVADYLKAAFRNN
DYVCRIGGDEFAILMVEMTTDLQYTIKNKIDSVNQQLSSPEKGIPKVSLSAGVAFSDREN
PGENIFEDADKALYKVKENGRNGCGFY
>A0A379KAX5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSQPAKPPSIIDLYPEETREAAELLKQAVPLMMRHNIPPNPVHYALWYTYSRGSEPELNR
RLDKVVEDFDAFPLKTASRLFRDYIIRGELEEARAGQQQVIELVDDIEGDVSRSVLGSQY
YQQSLSQGLSALQDPIVDDLPSVLSDLQESTQLIQDQQEKFLYRLRAAQQEITHLRSQLE
RAHLAATLDSLTRVFNRHAFTRLLERALNESYQGLALVILDIDHFKQFNDQYGHPLGDRV
LQHVGQLLRDLLPPEAFAARYGGEEFCVVLRNCANLNEVLDFAEQLRHKIQSLRIKVRRT
DQVLDSITASFGCAMAAEGDTFESLLTRADDALYQAKRAGRNQVHPTTSETMLSA
>I3X8Q0|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MPNANLMLLLAEALVYVASMIGLLHLRARLGLGVFVAALGVMHFIETYLAAVFYVQLPFG
VISPGSAVFFSGKLMMILLLYVKEDAATVRQPIYGLLAGNFLTVALSLLLRRHDTVSIVA
GRVADIAFIDEMGWLMVWGTTLLYFDSLIIILLYEKLGRWFRRFVTMRFLICGVVVLTFD
QVGFYAALHFVNGAPADVFWGGWMAKMLAAPFYAVAIGFYLNASRHTFLAISDRPLGDVF
NDLTFRERYEDLLSRSGRDTLTGALDRGRFEAEGQRMIRDAVAQSAPVSLMIIDVDRFKS
VNDQFGHLEGDRVLQKLAETVRAKLRPTDLLFRYGGEEFVVLCPGLPYADAHARAEDIRL
AVSAGVKTPNGHPVTASFGVSSTLADGAGIHELLAQRDIRLYAAKNTGRNRVVGR
>A0A379K581|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MATQTARLLKRLRNDFQLSIITLMGLFGVIGISPYAIYRLLEGNYLVGIADTIIVLSTLF
AVRYAWVTRDTVKPGIYLAAVFSVSATLIAINLGVNGLFWIYPLILFNFFMVTPGKALLA
TALVLVSLVSHALLVPGSVFESHYQMVSFLVTCMMASVLSFIFAFRTRTQRDQLQLLAIH
DPLTGARNRRAMNEELKIAMASHRRHSDSYGLLVMDLDHFKQINDRFGHHVGDQVLVAFV
ELIKRCCRKEDRLFRFGGEEFLLLLPSTEAEGLRTAAQNLLSRVANELRSPGGAVTVSIG
GAILHGGEHWESWLQRADECLYRAKSEGRNRAVIADAPNGQSKTATSH
>A0A655XRB7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMEMXXXXXXXXMHHFA
>A0A808FBV2|diguanylate cyclase|EC 2.7.7.65|Xanthomonas citri pv. phaseoli var. fuscans|TrEMBL
MGRGGTQAHTSCVRSTCVRRIGQAWLWLLWCCAVLNAWPAGAQVLKHTAYHTVTRWNMDD
GLPHNLVHAVAQGEDGLIWLGTWEGVARFNGRDFTVYDRQNTPGVELGGVFVVVRDSTGG
MLFGTAFDGVYHYQDGHWQQLGDASARHLAVSALLRRADGALWVGTPQTLYRIEGDGRVV
DVGRQTGLPRARVTALSADESGDLWVGTEVGLYRLPRDGGQAAAWGRVHGMRDAPVRRLA
SDRQGGLLVAGDDGVWWWSRGGGLQRFRQGQRVDSVLLDRRGHLWMSLSSGMLVVHSGPN
DPDEQIAISGVASPALLEDAEGLIWVGSTHGLFRIAEGAAHGVTHDEGLSSDYVRCVLQT
GQGTVWVGNAVGLDRWRDGTISRVSLSPSEGGRVLEQSVLALADAGDGGVWAGTYSQGVV
RLDAQGHVLVRIGAADGLPSMSVRAVLPDGDDLWIGTTAGLVRWRNGKARRYTPADGVPD
GSVQVLYRDAQGIVWIGTDRGVTALSPDGSTRAWLGEQDFPGQNAFDFLRDAAGDVWIAS
DRGLLRLRGDSFRVYDHRVGLPRDKVFRVIDDGRGYFWLSSNHGVFRIARDNFDQLDAGT
REQLSVEVVDRSDGMPSNQGNGSSAPAGWLTRSGQLLFPTAAGLGVIDPARVGTLQGHRL
PIVFERLLVDGMVQPLSGPHRFGAETRRIAIAYAGLNFRGPDKVRYRYRLEGFDPEWVDA
DNASEAVYTNLPPGRFRFRVQAMSLPVDWRQNDLLGEASLVIELAPPWWRRGEVIGLGIL
ALASVIYGFYLWRTASYRLRQRQLNTVIDRRTRELSDKNLALQQASQEREALMRQLEHRA
SHDVLTALPNRREAERVLQQWFDEAHAGGAALALALMDIDHFKRINDDYGHEVGDAVLSA
IGEVLGEQDQAHCFAARHGGEEFLLAATGLDAVQARALFERMRQRLADIEVDAQGMTVRC
AASMGMAMSEEAPSRRELLALADRRLYEAKRQGRDRLIGP
>A0A655Y8G1|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRXXXXXXXXXXMNPKHRDATKYQYSPPWKCITLRDAKSM
YAAKIIRRYLTACSDFHSALSSVRLSPPLTFASCTTLHRLVLLQTHLNSLVLQVGGK
>A0A655WHB0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQQRFPEFTLYTVPNTGEIKYGLGSDDQAKYVLSDVYPLDYDNRKLLGFYSERERFKLIL
TDIFANRRPNVSDKVRLLQDGIDKSIAKDGILVYHPVFSSEDESSLLGVMVGVVRLSTYF
DKLVQLSLMEQDLYMRVSDTGFDSEDSPILYQSPMWRADEGLKIDRKLVLPNRDWVLEFE
LHQPINHSEQWVLLGLGLGGVIISFLLSYIMRMQLEEKQRLTDMIDERTAELRYLVEHDG
LTNIYNRHFFSQHMCKMLDEKQSFTLISFDIDRFKQINDSYGHLAGDCALTHVVNVVKKE
LAESDIFARFGGDEFAILSSVTDKAALISYLERIRKVVETEPLMLNAETQLTLTISIGAS
INCDYSEPEILQSVDDQLYLSKSKGRNRVSIAQQCSKVESNYAFISGRMSDFM
>A0A655VXG8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNIAWQKGNNTTLATMNIGSLHTAIYHSLMEQIAVIDAQGQIVDVNRAWVEFGQNNGVDE
QYDWININYLDALYKASQAGETRAFEAYQGIQAVIQGQSDSYYHEYPCHSPNEQRWFLMR
VVPLKIEQYQYWVISHHNITQRKLAEMRSEFQATHDPLTGLANRRHFHQQLEALLLENQQ
QQAGLCLMMIDLDNFKHFNDTHGHQAGDLCLVRIAATLQHNFSVPCTAYRLGGDEFALLL
SHLTQQQSQDIAASVSQRIQELRLLCGNKLQVTXXXXXXXXXXRHIYLR
>A0A655YGT7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDHRFSTKLFLLLMIAWPLLFGSMSEAVERQTLTIANSKAWKPYSYLDEQGQPSGILIDF
WLAFGEANHVDIQFQLMDWNDSLEAVKLGKSDVQAGLIRSPSRLAYLDFAEPLLTIDTQL
YVHRTLLGDKLDTLLSGTMNVSLGVVKGGFEQEFMQREYPQLKLIEYANNELMMSAAKRR
ELDGFVADTQVANFYIVVSNGAKDFTPVKFLYSEELRPAVAKGNRDLLEQVEQGFAQLSS
NEKNRILSRWVHIETIYPRYLMPILASGLLLSIVIYTLQLRRTVRLRTQQLEEANQKLSY
LAKTDSLTDIANRRSFFEYLEAEQTRSGSLTLMVFDIDDFKTINDRFGHGAGDNAICFVV
GCVRQALASDTYFARIGGEEFAIVARGKNVEESQQLAERICQRVAEKKWVVNAQHSLSLT
ISLGCAFYLHPALPFSLHDADSLMYEGKRNGKNQVVFRTWS
>A0A7L6Z0W1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C15|TrEMBL
MNDENFYKQAVDLDETSLSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPMSREFANLKTDAVLAGMWMGLMGVNALPSAA
LLMIICMNLMGAGGVRLFVTGLALMVVACLVTLQLTGTSLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATRLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHREATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRITLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRIHEGLRGLRLACAPQVILHISVGVAPLTPQFSHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A655WU78|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MMDLSFLEIATVINNIACSAIAALFLYMLRSKLIEHKLDTATWFVLLFLAYGLAYTTSSL
RFILPMGFAIFVNNLLYQLGGYCMLFAVLRWYQKPIKSGLYLLMMAHSLLFALLLYLLFR
LNPEDIGLRILIASLSLSSVYLISAIVAAKNGQRGRPEQTLFAVVLAMMMVMLYVPFVAY
QTLPLLAVFRASTIVVQNLFFFIILGTMLMLFLFEEIEWHRLRSIQDELTGAFNRRHFKE
QVQQKLKQSKQKSMVALVDIDHFKQINDSYGHDIGDSVITYVVRHLESLALTECLVARYG
GEEFAIFARENDFERVSQALDSVRDAISVGFHVEQQPLKVSVSIGAVIFESSHEYGEVLR
QADKALYQAKQQGRNRIMLQDVSAS
>A0A7W2Z5S0|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-01064|TrEMBL
MQRDTYVVKRSLQQWLHQRSNPGLIVNLCFIIVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVANGLDRQLQYNVDKLLFFRHSMRDALQTPLAFGVLHNAVTRFNTLRNTTNWQIAVDE
NRTLPINGVSDAFVEKTTLLNRDNDRLANELSAALEVGYLLRLASSHSSNVERVLYVSRA
GFFIATDTPAQPRDISPRYYQLVTQPWFSQQSERENRARAVRWFISPPSPFIGNKRLITA
SVPIYYDHFWYGVVAMDISVDTMKQLLVEAMDNHSEGEYQLYDTRLNMIATSESPESEVN
HFDASELAQIAHAIESDTEGGIRLGSRFISWERLDHFEGVVLRVHTLHEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERANALA
KQCQQQSLPLSVIQIDLDHFKGINDRFGHQAGDKVLSHAGGLIASALRANDVGGRVGGEE
FCVVLPGLTLEEAANVAERIRARIDSKEILVKKSVTLRISASLGVSSAQEKGNYNFEQLQ
SIADARLYEAKQGGRNCVVWRDHNKK
>A0A7Z8BGB0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B3KJV6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
IGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A8B3KGN9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A235Y082|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A7Z8BLZ6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTRGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A7Z8BR53|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQQRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A1X9WYH0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>Q7DJY9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGHRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLG
>A0A840RF50|diguanylate cyclase|EC 2.7.7.65|Silvimonas terrae|TrEMBL
MESALIRLTESVSSARSLEELARPLLEMLHNLTDYESTYVTRIDMQAATQLVEFAMNVGA
LNIGENMTVPWSDTLCKRSFEEGRQYTDDVPGQWPDSVAAKALGIKTYVSAPIRSGSGEL
VGTLCAASKRQLPLSDRARSAINLFSKLIAQHMERENLLEQLQSANQRLALFALTDPLTG
IPNRRAISDELSRLLAAARREQTTVLVGLVDLDGFKGINDEHGHEGGDYLLREVAIRLSG
AARGTDMVGRLGGDEFVVVGPGPANRGDAHIATIAMTERFSSAASGVFGIGGRTVDYPGA
SVGFVAVDGSVSVDQALRLADGEMYAIKHRRKNMANVR
>A0A7W2Z6M1|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-01064|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSLNLAYTFVNIIEACVGALLLRKLLPWYNPLQN
LNDWIRLAVGSALIPPLVGGVLVYLLVPNAEPLRNFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTTVITLVLCWAAITWLPWPFTCVIVLLMWSAVRLPRMEAYLVFL
ATIMMVSLMMARNPASITPQNVIVAFNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLVSGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDAMV
PEDREHAEKVLRDSLIARLPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICTDIDMNVTFMNPVAEKMSGWPQTEAIGQPI
LRVLHITFGENGPLMENIHSGDMSRSDIEQDVVLNCRNGGSFDIHYSITPLSTLDGHNIG
SVLVIQDVTESRKMLRQLSYSASHDALTRLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNLESARYI
AGRLINTINNYHFTWEGRLHRIGASAGITLIDESNHQAAEVMSQADIACYASKNSGRGVV
TLYEPQQERIHSNRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESASFWLLSLRLWTSQ
GEMQEEHAFRSGLAEPELLHALDRRIFNEFFRTFAAPVAAKGMGVALPLSEAGLASVTLV
DELLDLLEKSPLPGRLLHLVIPVDVVRNPDENAQRNLQKLRHAGCRVVLSHVGRDMNDVN
HLSPNMADYLMLDTDVVNNVHGNLMDEMMVTIIQGHAQRLGMKTLAGPCHQPIVMDTLSG
IGIDFIYGDTIAEAQPLELLLNTSYFAIN
>A0A0E1CHU3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MRLRNILSARPYYPQERKLALVTHRRCRCLLCGILPMPEHVHHIVKRLILYICICLLAGI
GISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIACFMGMKYWSSKRRLYLTPVSFGFA
CSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFFRNIMMAVLFMSSIILYYFRQRIMH
SWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVNFIDDLSHTFTPLWQSIIGWLLMAV
WFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLSTAGELDQTWYQARFFETLCTLF
LILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHPLSV
LISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEKE
AQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNSVTAEACVQRADEAMYEAKNNGRNQ
VIVWHQQGG
>A0A8B4LFD7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MPFYFRKECPLNSGYLILVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQ
SIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKEN
DTLHDAYKASDERLYVNKQNKNSRS
>A0A482PK44|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium|TrEMBL
MEMYLKRMKDEWVTLVEQTDPQIRRLASEIATRHAHDLSIEFYRIVLADPHAEEFLSNEQ
VERQLKHALEKWIVDVLSSGVEDVERLIKVQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PIIIDGHHDANDKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEMDIIYKIMLDADFGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGLFLQSRETAKALSNKAARVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQADTLRIAERIRLRVEKTKIKSPDGATIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRQGRNRVELWSPAS
>A0A806UBE4|diguanylate cyclase|EC 2.7.7.65|Priestia megaterium Q3|TrEMBL
MNLDLTAYITLICTSGVLNLYLCFYVFIKRHHYANIAHLFILHTGFTTIYCMGAAFCLLS
VNLEEMKFWTAIQYVGMPFSPPAGLLFVMQYVGIKVRKKHIFALFIIPFISLIMVATNDW
HHLHYRVFEIDPVLGAPYVHQEIGPWYTIHGMFIFSSMFVAFLLAVYRWKETAKAYRLQL
ISLMVGQLVPIVTAFIYLMGFTPQGIDPVPMVLWVSSFLYLWSINSSRMFTVMPVAKDAI
FNSINDGVVVLDESYRLIEFNLASKNMFPQLKKSMLGKHFADIWVTLSGRSFPFALENTK
SSHELELFSEDQSSYTYQVRTSPLQYANNSHGLLLIFTDITELKRLQLKLENQAYYDELT
QIYNRRAFFQHSKQAFDEAKKSASSFTLLLLDIDYFKKVNDTYGHYAGDQVLVHVVKACE
SALPQGALFARYGGEEFVLALKGHTLSEGETLADQIRRHVETQPLLINEKTISVTLSLGV
AQAEKQENETLDELLNKADIALYAAKQHGRNQVRVYKEIKEILKRT
>A0A6L6INL2|diguanylate cyclase|EC 2.7.7.65|Escherichia alba|TrEMBL
MDKEHSSLSRPTFKRALRRINMISIIVTMTLIWLLLCVASILTLKEYAQKNLELTAATMT
HSLEAALVFSDGDAADETLAALGRQGLFSVAEVVDQNQKALAIWHYNPDESADKFSDLIS
RRLFPTPVVQPVRHNGEIIGKIRLNARDSLIGHFIWLSLAVLTSSILLAAGIAIVLSRHL
HNGVVDALRNITDVVHDIRTNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLMRTALHDPLTGLANRAAFRSSIGALMNDYSARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVARRLSDFGEKRHQPYRLGGDEFAMVLYGVHTEEEVHHICAALDKRLNRPFDL
HNGHLASMTLSMGYALTWEHASADKLQELADRNMYIAKHQRTERSIN
>A0A378K4Z8|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MHQKKRSSLELEALLSLFEGSLRTIPFNILAVMVLSLGFIYTNQIPIKLVIICFFLILIL
SVVRWVTSRIIISKEFYITKGKQALIGFLLLNFFMGLAWSLSYFIFSPYLNDTSEFIFVF
ILGGLSTGAIASLSIYLPAYYAYVLPMNFPIIAYNLYLFQFDKAIFAVMYSLFLIIVLLT
ARLNSKLLSKVRVLSITDSLTGLFNRRHFDVVFRNELSRAKRNKYPISLVFIDIDNFKYI
NDTFGHSVGDSFLIHVSNILKQTLRRSSDSLFRIGGDEYAAILINMPPSEAITVCALLQE
QFNKKNQYKNVSLSMGVISIDSIRVIDQQSAITAADKTLYQAKKAGKNQIKSKSLG
>A0A7Y8YET9|diguanylate cyclase|EC 2.7.7.65|Kalamiella piersonii|TrEMBL
MSVELLSSLDKPQNRLLSALILAVLAFVLTLFCLELIVFSGRISPLWFATALMTIVAFRA
PSRHAPLLLLGCVAGTGLANALIIGPELANLKFTLLNVLQAILGGVLLRGLLSRQAPLNS
LLDWLRFVLSVGVLTPLLGGLLALWMLNIHGSGTLPFLLTWVISEVIGMLALGPVLLLMP
WPLRIGSISVRRLAEFLFNLLLTAGASWLALRFMPWPFTFIVVILFWCAVRLPKREAFLL
FLLNACTISLVLALGLVSIETPGNAPGQIANWLPFLLVLMPSHVMSLVMDAFQREKHHIS
ESETRFRHAMEYSAIGMALVSPQGVWLQVNNSLCQTLGFPAAELKKLTFQQISHPDDLEN
DLQHADRLLRGDIDAYTIEKRYFRKSGEIVWARLTVSLVRDAARKPLYFISQIIDISELK
QSEQVNRHLMERITLANEAGEIGVYEWNLVRNEMMWDRHMYALFGLPAHQQPSRELWRSQ
VHPADRERLDLALMTSKESADVFDIEYRIQRADGVHTLRTQARRFFSQDGRLERMLGICQ
DVTHLRNLTDALFQEKERMAITLDSIGEAVISTDSEMRVTFMNPVAEKMSGWRQEEAAGK
PLSELLHITQGRHGPPVENLLLRRLPTEKTTPELDDELVLHAADGGVVEIHYSITPLRTL
EGEEIGAVMVIQDVSESRKMMKHLSYSALHDTLTGLPNRASFDRQLQRLLNDAVEHQHQH
VLAFIDLDKFKAVNDSAGHAAGDALLRELSGLMQRHLRGTDFLARLGGDEFALLLPECPI
AQGCEVVQRIVSAVNGYTFNWQNDIFQVGASAGLTQFSATNGVGAEVLSQADIACYNAKK
AGRGRLTIYAPEAH
>A0A3D5MLN8|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp|TrEMBL
MQPSFPALADPQHAAQFGVADPASVRRLRHLVQDHAEALVAAFYDALLAHEEARAFLHHS
VVQERLSPSLRRWLIDLFAPEADGDEAGFVARQVKIGEVHARIKIPMHLVMAGAAVLKRR
LAEVLASEPAAFDLLRLSGERIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDVNFER
ESQRAGLMEWSQKTLFRILASGGVDGAGALSASPFGLWIRHRADFLFDGSPHLARLNEVM
ERIDLELLPRFLPGAAPSDLAAPLTALEAAVDEVAFLLNEMFQGLAGMEGGRDPLTRALN
RRFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPIGDEVLRQVAEAVTENVR
PSDFVFRYGGEEFLVVLVETGLRQAAIIAERMRQALAAKAVTASGLAPFHVTVSIGVAEH
GGHPDENYLVKQADDALYRAKQNGRNRVEVA
>A0A5E4U452|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MTTRLPPTHPPPSGAGSAVAGLLSPQTPPPDVYSTGTGTGTGTGTGAPASSNASTPPASP
PAAPPTHQAVRSATTGTTGRRRRPSLQGLLRRTHLRLAVSAVVLAAVSLSLVAWLALRSY
AENNLQLIGRSLAYTAEAAVVFGDRVAAQEAIALIANDEDVVQVRVLDAYDNQFALWRRA
DGGTLARVERIVADFALPGPVTSPIRHDGKEVGHIEVQGQGHQFFLFLISGIGGVLACLL
VTFAVANLLAKRMHRDIVKPLRALAEVAHAVRRERAFHQRVAATPLAELKELGDDFNALL
DEFEGWQSHLRAQNATLAHQANHDPLTGLPNRAYFESRLSQALVDASELGTHVALLYLDS
DRFKEINDQLGHDAGDAVLVAIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRL
AQSLLASMEKTIALPGGGEVVTSMSIGVALYPTHASDASALLRSADAAMYQAKRAGVGTW
HVAESPKG
>A0A086ZFT3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bohemicum DSM 22767|TrEMBL
MTKPIEASIVVVDDEPSIRDLLVASLHFAGFEVSTAASGSEAIEVIEKVVPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPVIRVGDLEINEDSHDVSRAGQTIELSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKIDGIEFMGDDGKRHKVIPLIETKRGIGYMIRE
PKTASDQ
>A0A735PWK1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:z:1,5|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWKLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A653KJU1|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MHNLFSSAQLLSLVLFVTLSHVGVAVIFAYVWHTQRRIRGLLYWSASELAIAASFCGLLL
RPLEGDISLANILLTNLLLLAAPLLYERGLRHFFRREADQLGWLCPAIALIGFVLFALTA
SLRPLSDVHSRIMVLSAVLSLQFAVLIWQLWRYQRLAPLYRVLRFAILLLGLQLLLQLLR
IAKHLWQPELNASTFTDPLLGPVILLSLLFTIARSYLLLSLVHTRQQQALLATQRELERR
ANQDELTGLLSRHYFQQLLQAQVSAGANPCQLLLIDLDDFKQINDQHGHPAGDAMLRLVG
QVIRTTLPRQGIAGRLGGDELVIFLMENPQTLPHYCHTLQQRIAQATSQLAGGPISMSIG
LTSLQPGERFEQAYPRADRALYAAKQGGRQRTCVQESHHSEPQLLQPLVTGS
>A0A8I0MPJ2|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRKLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSGEADNIDELIKVQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDGQYGSVEKLQVYHYSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFTLLENAEE
EKERQIGALLSWEMDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHSTSSTAKALNNKASRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRANTSLSVLIIDVDKFKEINDTWGHNTGDDILRRVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEANQTDTLRTAERIRSRVEKTKIKAPDGEIIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A2S4S2H4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MENWRWLKRLARRFGPGHVVNICFVVVMVFSTLLTWREVVVLEEAYISSQRNHLENVANA
LDKQLQFNVDKLLFLRNGMHEALVTPLDFSVLQQAVTHFQQVRKEHFWRLELDTRRTLPL
YGVSDAFVEQAKFLSRDIDRLDNELIAAMEVGYLLRLAQSPVSLASQAMYISRSGFYVST
QPGAYDSEILNRYYHFVIQPWFSGQSQRQNRMRGVRWFTSLPVQSGEQPQVIVSVPLDNN
QYWYGVLALEIPVSSMKRFLEDAIDKDIEGEYQLYDSQLKLLTTSTPEQRNVNIFDEREL
AQLANDIEHDTQGGTRMGSRYISWERLDHFDGILVRVHTLSEGVQGDFGSISIALSLLWV
LFTAMLLISWAVIRHMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFEKARTQAARCRTQH
QPFSVIQIDLDHFKSINDRFGHQAGDRVLSHAAGLISGTLRSQDIAGRVGGEEFCVVLPG
TSLAQAERIAERIRRRLNDKEILVAKSTTIRVSASLGVSGAEETDDYDFEQLQSIADSRL
YQAKQIGRNRVCSRDE
>A0A6I6DLA2|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 119287|TrEMBL
MNKKYQRVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTFLAPLWFPTSIMMVAFYRH
AGKMWPGIAFACTLGNILASWLIFSWASINFWYAGVNIAEAFVGALLLRKLLPSYNPLQN
LADWIRLAIGSAVLPPLLGGVLIYLLVPGDEPLRSFLVWVLSESIGSLALVPLGLLFKPH
YLLRHRNPRLLFETLLTMAVTLVLSWISLQFLPWPFTAIIVLLMWSAVRLPRLEAFLVFL
VTVMMVSLMIAKNPTPLATQYASAMINAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSVIGMALVSTDGQWLQANKALCQFLGYSQSELRSLNFQQLTWPEDLESDL
EQLEQLLNGEINSYSLEKRYYTRNGEVVWALLAVSLVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDVKPNVISWDKRMFEMYEVPAHVKPTWQLWHECML
PEDRALAEQVVRDSLAARIPFKLEFRIRVKDGIRHIRALANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVNMNVTFMNPVAEKMSGWLQQDALGQPI
LSVLHITFGDNGPLMENIHSGDMSRTDIEQDVVLHSRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRELSYNASHDALTHLANRVSFEAYLKRMLHTVQDTRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDMLARLGGDEFGLLLPDCNTESARYI
AGRIIDAINEYHFMWEGRLHRIGASAGITQIDERNNQASEVMSQADIACYSSKNNGRGVV
TVYEPQQERMPDAPGTISLDEQWHMIKDNHLLMIARSVASPRIPESSTFWMLALRLWTND
GEMLEEQTFRAGLAEPELVHALDRRILQEFFRNFATPLTSKGTGVALPLSMAGLASATLV
DELLEMLSASPLQPRLLHLVVHVSVLTLEDEHSRNNLDKLRQAGCQIILSHVGRDMEVFN
HLSAQMADYLLLDPELVINVHGNLMDEMLVTIIQGHARRLGIKTIAGPSNQPIMMDTLSG
IGIDYIFGNTIGEPQPLELLLNTTYFAIN
>A0A6N2VFT3|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MKLPHKALRLFISASVVVLTSSFLIYELIASYKSMNGYMRYIIEKADSSFLYDKYQNQSI
ASHLMRTLATLEKTLPADTRHTLCQSFESVNSVYGLNLTQHNYPALHGTLQTSIDDCARI
ADDVLLLPAFDQAVKVNREQVDYGKGLATSEEKFHYYLDLQNQYIYFYDPINTRQFAMHH
WAFLQKGSLGIHQADIDELFSGRTVLSSIYQDDRTELNVMSFLTPVYLHGKLKGIVMVDI
NKHNLQNIVFTHDRPLVWRYLNASVTDTDSDKTIIIHQSENNLFPYVNYISDLPGGLHVE
LSLDILYFIVSSWKLFLFYLLATALLLNMVRLHFRLYHNVTRENISDAMTGLYNRKILTP
TLEQRLQRFVSTGTPVTFIAIDLDKLKMINDTQGHHEGDRAITLLANAIEASVRKSDYAI
RLGGDEFCIILVDAEPDMAARLPERIANHLRTVAPEKDIRFSSGSYSMQPNDSLQDAYTA
SDEQLYLNKHQNRQRS
>A0A7Z8DSE1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHS
>A0A200NJK1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A841L4Z0|diguanylate cyclase|EC 2.7.7.65|Polymorphobacter multimanifer|TrEMBL
MQIGFVGASDIGEALLPLLPPDTSMVMLTVEDATARAAAGTLQLLIVAPDCPSWRSMAER
LQPLQAIAEANPFPVFALVPRADPQALVQAFDMHCADCAWLPVDPMEVRARLAALVRRRR
VALTRAAEVRKAWRVATRDAVTGLFNRHHLERVLPQAIHTAHRENRILSVLMTDIDGLKR
FNDLRGHLAGDVALRRVAEAIEDNLRPADTVARYGGDEMAVIMPDADRAVAAAIAARLVA
VVASLGLGCYGPEAERAPLTLSVGMATLRGPGCNADSLLARADQALYEAKRQGRNRANAA
A
>A0A1H8QLR3|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MQCEQLFARCGVILANRLKERAAITLSHSFCRRQDERILNPFTTVLRLQTRKPNDKSAQK
CTDGPSAINEVASFFRKNARNARGIAVFNITTGLAIWCSEAMTLALVAFMAWRHNVRNKT
YFYWGMGFLLSGVGFAMVALRGQISDILSIEIGNAIALCGQSAWVVGYLALDRRKVEWWA
LLPPLVWLAGVFLPWVNDDYTNRVILYNLASATGATALAMAVCTAAWRNEGSRSKLGAIF
VIQSLLCFGTAMAMAVIGPTEAEAANFAGAAAMATGFLLTLACALTCLVIMERSEKHLRM
LSLTDSLTGVLNRRGLFGRFDAIQESAFQNNRQVAVLLFDLDHFKRVNDRFGHQAGDIVL
TVFARMARQFVPAGAFGRMGGEEFAAFATAADQTEAEALAESIRAEFCRIPVSTGDAIIP
ATVSTGVALASAIEANRDKLVSAADRALYAAKAAGRNCTVIFGEAEAAAPPPPEPDQTSG
ELVPTLDDQIHALRRVGSLS
>A0A5E4V3T1|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MVKSLKGRVAATTAIVSMILIVGVAVGIEFFVYGELRSSMQAQLDTQVKLVAEQLDDKLR
GKFLALHRMARHIGNPYAMTVAQFDAFANMSVSMPETFNTFFVAAPDGRMLYDSTFPATA
INIADRDYFRQVLAGAPQAASGLIAGRITRSPGIILAVPVVDAQGNTIAVIGGAINLLRQ
NFMVDLASNAVGTTGRYCVTTNEAQARYVIQADVTKILSPVGPVQTLCGVRDPGPNHLLR
MHPLVARASMATTGWSVVAVLPGAEAFDPLARVRRRVTLLAIAVIGLAAFAMWWMARHML
RPLDTLRDLVQRSAGDMRAVQSLPVQRADEIGALANAFRDMMEQLRDRTEALEGSREAAR
ANVRRMQEIADRVPYLVAFLDSEERFAFVNRACETRLRRSRQRILGATVSELLGPSLYRE
FAPHLARAFAGEAATFIWDFGEDTAYRCFEVSYQPEWAMHNVLAGVHVFVRDITVERSNE
RRWRRESHTDHLTGLLNRKGFDQALASALRGARDGGGAQALLFVDLDRFKLVNDTWGHAL
GDELLRRLAKRLVACVPEGDVIARFGGDEFAVVMRNVQDVLDVERTAMSILEAASRPMAL
SVGPVTVGACVGVAMVACGEVKTPGMMFEAADRALYDAKHGGRGRFVLGDGACVEH
>A0A379AM01|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MLDPLTGLYNRRGLKNRLDNILENHAGSHYVLLLDIDHFKSYNDNYGHAMGDQALARVSV
AIRDAVRSRDVVTRYGGEEFLVLMTNVNGSIAMKLAERIRQYVLDLEIPHLFNETVSTHV
TISAGIAPIYDNEFDLAVANADSALYVAKNQGRNTILAWEDLPRKQHQTASEHA
>A0A7W8QCZ1|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia atlantica|TrEMBL
MDTSKPQQNAATLHPAGEAQAQAHALVTEDAPGLAIDDSLARILAAPPAAECPITVLLVD
DQAVIADGVREALADEPGVDFHYCASWEDAVRCAEETRATVILQDLAMPGTDGLTLVQQY
RLNPATRDIPIIALSTREEPLVKSAAFAAGSNDYLVKLPDRIELIARLRYHSRSYLNLRQ
RDEAYRALRQSQQQLLATNLELQRLTHSDGLTGLSNHRYLDQHLADEWRRGTRDKTGLGL
LMIDVDNFKGYNDTYGHVAGDEVLKSVAHTIEACLRHSSDLAARFGGEEFAVVVPGTSAG
GLRLLAEKIRIAVEDLAITHAGSAEGVVTISIGAALMVPSAAEPVTTLIEAAGVGLYRAK
HDGKNQVAVSG
>A0A011PVZ5|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MWIEVRDEDGRVLIWNRAAAEISGHASEQVVGHGDVDGWLYPDRARLDAARSRFAAARRS
ESPAGVKTTIRCRHGDDRVMVWHTATLPADASATGGLLILGLDVTAQERAEAALQQSEAN
YRLLVENQSDLVVKMDTANRFLFVSPSYCQVFGRNEADLLGQTLMPLVHEDDRAATAAAM
EDLFRPPWRTYLEQRARTGAGWRWFGWADTAVLDDDGQVVAIIGVGRDITDRKLAEEALF
EAKERAQVTLDSIGDAVITTDGRAIVEYLNPVAETLTGWSAADANGRPLQEVFRIVDERT
RQPAPDPVERCLREGKVVGLANHSILVGRHGWEHHIDDSAAPIRGRDGQVLGAVLVFHDV
TENRQLARRMEYDATHDALTGLINRQEFERRLERVVNSARQYDARHALCYLDLDQFVKSG
DSILNCPFHQRRQKVPRGACMRISGRRAALPAVDAAKNGPGRAAQPPQQAG
>A0A127K8G3|diguanylate cyclase|EC 2.7.7.65|Thauera humireducens|TrEMBL
MHKSLPAQTTETIENDWLALFDQAPLGARAAVRDIIATHREAMADAFYERMMQDPEARAF
LSSEVVHERLHASMQRWLTTLFSCETREQFLTAMAMQRHVGEVHSRVDVPVNIVARGARV
LKNRIGGYLARSPLGRDELVEAVIYVDSLIDLAFEVMSSAFVASHERTARIDEAYRSFSS
GQNMSLERERQRSALLDWENRLLQTVMTGQPGDDLPSVSGSSFGLWMQHKASALFRGASE
HATVRKLMRSIDETLLPLCAQQLGAGNLSEVRHLLKQVQAEVGELKFLIESMFEHLVDLE
SGKDALTQLLNRRFLPAILARECEITRSEGKPFALLLVDVDHFKHINDAHGHQAGDRVLQ
QVAAILQNSVRSGDFVFRYGGEEFLIVLVEMDHTRAMRVAEKIRTRIAAEPLLISNGGQL
NVTVSIGVAMHDGHPDYQRLVNRADGALYRAKQGGRNRCEPDLPDANA
>A0A011P8E4|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MPTPTNPSEIAREAFRLLASRRLPPSPENYRALYHEIAGTPAGAAAPFPERELKALLSAL
PKEKPAQERLLKRFEQAFKGKTWDELKRGLGEFFAQLGKEQDLPWSELFGDFLRQWESKQ
AGLTVARKREAVERVLAGAAGNSELLFTRLQGLVRSWSLNAPMAEEIPLVEDDKAVTATA
APSAKPSTADLAAAAKAQQTSAQAAELSAELSEIFAYTLEVLVPSQLHDEPELVADAKAL
AHKIRTATSRAAMDGLQASIKRFAFRLEILAEDRVELRAGLLNLLQLLIENVGELVVEDR
WLAGQIEIVRDIVAGPLSIRSIGDAENRLKEVIFKQGQLKHSLNEARESLKQMLAGFVDH
LAEFADSTSDYHDKIEICADRISNAEDISELEDVLAEVIRETQIIQLNAQRSRDELRNAK
QSVEDAEKRIGELQAELDKASTLVRHDQLTGVLNRRGLEEAFEKETARAQRRQSTLCVAL
LDIDNFKKLNDSLGHDAGDAALIHLTTVIRETMRPQDTVARFGGEEFIILLPDTPLEDAQ
TALVRLQRELTRRIFLHNNNRQLITFSAGLTDLRAGDTQASVSKRADEAMFAAKQAGKNR
VLLG
>A0A5E9H4I5|diguanylate cyclase|EC 2.7.7.65|Carnobacterium divergens|TrEMBL
MQTSELLIRSLENISVIYFFISVIFYLFDGKEIITVYSTYWKKLLFGISFGMLALLLTET
AINEGTSELSYSLIPIFICFYLAGPFAGMTSFFVLSVTDRVAFSFFNVTYMLVIFMFLIV
LRVWEKRSVKAFSIVLFILIFYSLVLIFIFYPTAIWKPSIWIFELFCYLSSVICYFFINK
QRIYFQSHLTLVDESRKDFLTELYNRNYLVKLIKQRDAKQKRYSILLLDIDHFKKINDHY
GHAAGDTILMQFAALLMRKTSGRNSLVFRYGGEEFIVLVDETDREKITKLAETIRVAVET
YPFILSEEKKIAVTTSIGVSFKLNEKQRYQEIINQADEALYKGKAQNRNQVVVFDEK
>A0A1E8E225|diguanylate cyclase|EC 2.7.7.65|Acinetobacter towneri|TrEMBL
MSQECMRELADQWKIICEQYSQADLEATFQFVQRHADAFVLEFYKQMMLEEQALEFLSVE
MVQNRLKNSLHQWLVSSFEVPFKQNYLEIVEKQFKVGDVHARVQIPYWLIIRGVRIIIKK
AFVFLAQEAYTNLNQINYLCQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVQ
KDRQRGTLLDWENELMFQVVSDNHNLQQPILSKTEFGLWFIHKAAYAFSNTEQVGTITER
IYQVDELIQQIKSCENQAQVVEMIQLIRAKNREILYLIDQIFQVSEYISSGNDALTQLLN
RRYLSTIVAREINFARKHKTRLTILAIDADHFKYINDRYGHAAGDEALQFLADSILQYTK
GSDYAFRIGGEEFLLLQVDTNVERAVKVAENIRRRIAERTVNTSTGASFNFTVSIGVFEY
DGHPDYQRFLDSVDKALYVAKNNGRNNVYMG
>A0A128FJK1|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MKKPELPIDETHRLEVLYHLNILDTGNEERFDRLTRLAKQMFGTKIAAISFIDTNRQWVK
SGKGLDREYPRDISFCAHAILDSDPMVVNDTLADTRFSDNPLVLGDPRIRFYAGYPIRHV
SGSLLGALSIADDEPRGFDDYDLRCMKDIVDLVENELASMQLSTQDHLTGLLNEHGFEVI
CQNSLNMCERLNAPASLAFFDVRGLKTINKLRGNVEGDRALAFFADLLKFGFRDSDVLAR
LESDKFAVLMNNTPIANTQEILDRFKERVDRYSVENALPYTLDYYVGVSWVEPESNYDFS
NLLDIARNFAVKAKG
>A0A624B2A5|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDYSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0J6WFH3|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MSAEALPIPSAGPRFAEADYVRGMTRLADVIQQLSLARTMDEVQRIVSATARDITGCDGA
TFVLREEHMCFYADADAIAPLWKGRRFPMHSCISGWTMLHKQAAVIPDIYLDDRIPHDAY
RPTFVKSLVMVPVRRRDPVGAVGAYWAEQRTPTEYEVALVQALADATSVAIESVQMHAAL
KQMTAERQASAPAAPSGMDATFAAAFANSPLGMAVVGLDGSFQRLNREFCRITGYPEHEL
MRLTFQDITHPDDLDIDLAEASRLLAGDIASYQMDKRYYSRDGHVIWVRLSVFVAYDDSG
QPLAFISHIEDISARRRDEEILRRRATLDALTGVYNRSRFDEELAKYAAQASPHATADPA
AVFMIDLDGLKQINDRHGHIAGDAYLKTVADTISRRLRLSDVVARIGGDEFAVLLPHTTV
AHAQQLAQTLVDQVGALSPGGICIGIAMVTPDTVDDALERADQAMYRAKRSGGSDWCGPE
PYPTD
>A0A0J6VXG7|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MSGWWRHGGRFDALSAYLRDRGLETQWRIAIFAFTCTLGTLPLILLASPVGASTPVARAV
AIAAGVGAIAVSTVWLPGWPTRTRSLVYNLVCCACIAAGSLSMSYAYAGLMGCVMFAVLG
GYLAYFHRLVDVVGNGGVAAVCAVITATRLIADTGDVAVTIASVVTVVALNVGVPFGIYS
LVHSLHADLAESGRDSLTGLLNRRSFHQALRQLIADQRSGAAVNVTMIDLDDFKGLNDSR
GHATGDRALADVGDVLRHTCGDAAVLGRVGGEEFVVADTGTPSGHAETTNAVRAGIAALP
FDITASLGTCTALLDDHVDDPDDADLDDFLDRMIATADAAMYRAKRAGGDRVEHRLLTPS
SRQQD
>A0A128EVL5|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MSNFSSDDDVILFKEKLQHSQLVFRDLALKSRREATILKRLISRLVAASQVHDDPLLSER
LSQIRRELDSQEDVSRLIPQLALVERMVNRHNQATERAKDSLECQFQQSGETLKCLPGLP
AQLKRDLRTLLTTPAAEQKGSTDKIVALLQLYERALKLLSLPSSGHSARDLLNIDRINQL
CSELQHLITELDFDGEVGDRLLDIRSRLLLSPDAQTLLELTLESVQLILDGTRNERKASQ
AFLSQLNDDLSILQRHNGRSIDNSQAIATQRSSLNEELAASVDSIHNHLQEAESLEELRP
NLSQVAVNLASLVARNRELEEREQLLMEQLQHNEQKLEALYQQTMDYRRRLGDQERKLLL
DPLTKVYNRAALDDRLEHEYRCWVRYQTPFCLAMIDIDHFKSVNDQYGHLVGDKVLKVVA
RTVHQCLRDTDFIARFGGEEFVVLLPDADEDTRKALLNNVRETVSKLPFKFKDTRLTITV
SIGASLFKDNDNTVDVLERADNALYNAKHNGRNKLVWA
>A0A564G6E8|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MPPQPPAATPVLATRLIRAIFGCYFVVAAALTAVQLAVEYGDAHDHLQRDVAALERTFGP
GLEDAVWRFNGEVLRGILAGMREIPAVVGVEVRDEKGRRVEAVGAVAEADSGAASPTRVG
GLGTRFSRRFDLVHVDETGRRYPVGSWTVFSDTGIAIEQVRRTLVVILINSAIKTVMLWF
IFVAVIRWMVGRPLAQVAAHLARMDRETLAEPLVLRGGGRHELHALVAALNATTDRLRRA
FEERNALTHDLTEMNATLQARVAARTRELEALAATDQLTGLPNRRRLDAALDEALAAEAG
SGLAVIVCDVDQFKAVNDQHGHTVGDAVLGGIAGILAQAQGPGDTVGRWGGEEFMLVCPG
ADLAAARARAEALRVRIEASALPFVGPRTCSFGVAARRPGEAVDGLVARADAALYRAKRN
GRNRVEIEESIEARDAA
>A0A378PGS7|diguanylate cyclase|EC 2.7.7.65|Legionella steigerwaltii|TrEMBL
MVFPVVMIVVGIVFLISGAYLIKSVLQQTNHYRWQWLVYLAFIGAFILSYSASIFYGLLV
DPHCLNYFYGSVFLLGATYVYLSCRLMTKTIQKMEVMDDFKNRYELLRHHTKYDSLTGCH
NRETLFDILNTRFQHIKSNDGWVIVLFIDMDKFKAVNDRYGHDVGDNTLTAFGQLLRQRL
RKEDVVARYGGDEFIAVMEHISVDEAKKIAENLITVTKQSFKKGILSKLNLGCSIGITQM
NSHSASVNAVIKEADLACYAAKQRKINGSVCVYSTMLATTNNPIDLGIHQVTE
>B2U419|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MPFYFRKECPLNSGYLSIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VSRENISDAMTGLYNHKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTFEVA
>A0A1A8T4M9|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MTESAQDKLIGALRKAISRISLLAEGNDPEVDSVIRQIRQNITKGADADKIQAMLSAAEP
HLLNSEETHLNRAKQVRETLHDLIDLLEVNHKKRLPSSEKKALESLIRLHWQSPPSWPYL
FSSYLALAKTTLSLETTEESSKQSLIKRLFHRTKKQQDTQNSQEIMAQISHTLSSLLTNL
SLSHEYDEQIIALREVLANSNDLQQLPDLLDEVINLIIISTGKTQEGLTNYLNELNQQLA
SMNTSIVSHYKSQKTLIENRDGLNVKLEKQVSDTNLATQSATDLNELKELIDTRMKAMTT
TMVDYKQQMMLLEKETHQSIISLKSKVDQMEKEASSMRTKLQEKLAQAMTDALTNLPNRA
AYQDSILPLVQSSKKSGKKLFLAVCDIDHFKQVNDTWGHQAGDKVLRLVTRQLLNSLSNK
DMIFRYGGEEFVALFVNSNEQEAIHKAETIRAAVESAPFNVNGAPITITISIGMACHRVT
EDHDSLFERADKQLYIAKQAGRNIVKVDQTKE
>A0A080M768|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MFKHDHSSLVHSSRRASRRFHRRPTLPALASAQPPGCLPAASGRAQHAHVRRFDTRKPEA
TALELLAAELRIGDLERALSEAREAAHTDALTGALNRHGFAEAYQRETARSRRNNSPLAL
ALIDLDDFKRLNDTLGHQVGDEALVHLVRVMRSALRPSDILCRFGGEEFVVLLPETALSQ
AINAIARFQRQLAAQAIPGQEIVLTFSAGVVVQQSGESLEQSILRADVATYAAKRAGKNC
VVTG
>A0A142M8W2|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MTARILVVDDIPANVKLLEVRLLAEYFEVLTAFNGPDAIAACEDGKVDVVLLDVMMPGMD
GFEVCRRLKADPATAHIPVVMVTALDHVTDRVRGLDVGADDFLTKPVNDLQLITRVKSLV
RLKVLTDELRLRASTTHSIGVDELLARSDLLKGELPKVLLIDEQSSSAAHICALLDGAAD
VQIAADPQSGLFNAAEGAYECIIVSSGFSDFDPLRLCSQLRSLDRTRSLPIVLLVNKEED
DLTVRGLELGINDYLVRPLDRQELIARLRTQVRRKRYNDELRQSVSQTIEMAVTDGLTGL
HNRRYLDSHLPRLVERAAARRRPLSLMITDLDRFKRINDTFGHDGGDEVLREFARRVKKS
VRGIDLACRFGGEEFVIVMPDTEGSLAEIVAERIRSEIARTPFKVGGTEQGVSVTVSVGV
SALVMEGDTVAGLMKRADLALYDAKTRGRNRVVARAA
>A0A0E8XF83|diguanylate cyclase|EC 2.7.7.65|Yersinia wautersii|TrEMBL
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHILTWNNGAERNTGYCAEEVIGQSFELF
YTPEDLVNGLSVKGLKHANQFGHYESQGWRVRKNGKRFWGNVTLSALHNSENILQGFVHV
TRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGRILTWNKGGERHEGYTREEI
IGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAINPIHDDRG
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHN
IGYVSNEIIGQHFGCFFLPEDIAAGLPGKLLKTAASTSRVEHEGWLVRKDITRYWALTVI
TAIHDHSGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNS
EGRVVLMNPKAEEMTGCKQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRHTLLPE
GHHLVSRRGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGL
INRRRLEERLTQTINQLAHDGQHMLCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCPSKSAVEILEQVVADIAAIQFHWHGQSYVLTASLGAIPL
TQQTESASQAMRLADIACYKAKHAGRNQLSLTS
>A0A7S9DR27|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MKIMTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKS
CYGLKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLP
DGEIAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALM
TDESLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVAR
LGGDEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEEIHTECS
AIMQDADERMYEIKKGKR
>A0A1J5QYS6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MADTDPDDELYLSTAAPSVAQQRLALAVFGVSLALFVLAAPFARVQFAGEPAFLPGVQSA
YVVVAATAAALLFGQYLTRPSVAMLALVAGYLYAALMGLVHTVEFPRLFTADGLFGHAYE
GTAWLYFLWHGGYALFMLAYAALGGARRWPLSSAQARRLAWLVLGLGVPALVALLTWAAV
SPAAHLPALMRGDLDGSRKFAVALVTWLLGAGALLALWRKRPRAVLDLWLLVAVAADMFD
TALAAVLNHARFDLGWYAGRAYGLLAGAAVLLMVFYSNGMLYAQLARLRAAERQRARERL
QESEGRFQATFEHAATGIALVSPDGRFLRVNARLCQITGYRADELLARRFHDITHPDDLD
ADLSELRRLLDGEIGSYTLEKRYVHRDGARVWVNLTVSLVRTREGAPDYFVAMVEDITTR
KATEAALAESQQRLQLLIDHAPAALAMFDREMRYLAASRRWIEDYGLGGRPLLGRSHYEI
FPEIGAAWKAAHQRALAGEVIRCDEDRFERADSSECWLRWELRPWHAADGEIGGIVIFTE
DTTGLVEARRAIVELNAGLETRVAERTAELAAANAELDAFAYAVSHDLRAPLRAMSGFAQ
ALREDAGEALGEDASADLREISAASRRMGELIEGILALSRSTRGEFDRSVVDVSAIATRV
LREFGAREPQRHVDCRVEPGLAVQGDARMLESALANLLENAWKYSAKVDAARIDVYAETD
DGRRWICVRDNGAGFDMAYAKRLFQPFQRLHRQDEFPGMGIGLATVQRIARRHGGEVRAH
AEPGRGAVFCLYLPAAAPAPAP
>A0A1J5S2R6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MATSDDPEANPPWRDSNAELRLLTDNVPAMILHLDRELYCRFANRRYVEFFGFGNGSPVG
KPVREIIGEASYREVERHFAQVLAGRPVSYQRIVHHRSGEPRHIEAKLVPSVTKQGSVAG
CYFLATDISEQKQVEQALCDAVAQLRMFADNVPAMTVSYDANLRCRFVNKRFAEFFGFTV
EGMLGKHLREVVGEDAYREIERHFVLVLAGVPVTYQRLRKLGNGECRHLEVKLIPHLGDD
GKTQGCFAVTTDITEHKQAEERIWYMAHYDNLTALPNRLLFNDRLSQAISLAKRDSRELA
LLYLDLDKFKPVNDDLGHDAGDELLKNVADRIRQQLRESDTAARVGGDEFTVILPDIAGR
EDAATVAGKIITALVAPFELGRAERSAAIGVSIGVALYPADGQDREALVKAADSAMYDAK
RAGNCFCFR
>A0A1J5SB97|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFKTVALQKAILNSAHFSIIATDAQGVIQVFNIGAERMLGYTAAEVLNKVTPAAFSDPQE
MIARAKSLSIELGTAIAPGFETLVFKSSRCIEDIYALTCIRKDGSHLSAIMSVTALRDAQ
GLIIGYLLIGTDNTLPMKIEAERQQLALRLSDQQFYTRALFESSVDALVTTDLEGIITDV
NRQMEALTGNTRDGLIGAPFKSCFSDTEHAEAGFKQVLNGIKLTDHELAVSGRDGKETVV
SLNATTFTDRSGKPTGVFADARNITERKQAEKQILYLAFHDSLTQLPNRRLLDDRLRQAM
TVSKRNGRYGALIFLDLDNFKSLNDAQGHHVGDLLLIEVAQRINDCVREVDIVTRFGGDE
FVVILGNLDADKATSTAQTMVVANKIRTTLNHPYVLKVRQEGTADKAIVHHCTASIGVAL
FLDHEVGTEEVIKWADIAMYQAKEAGGDSIRFFDAE
>A0A1J5T7K5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MALDDVTRDELQGIIAQLKESLYNHQQWHGTLIRTLVCKLPGDKHDASDTAHMECRFGQW
YYSKAPEKLRKHPGFIALGEEHERLHHMARLLLIAAGAGNPIAPLDYDNFANALERLRLE
IFALERELENSLFNHDSLTGAITRYGILPTLREQQELVKRHAQLCYIAMMDLDNFKAVND
LHGHAAGDTVLAVSVRYLIKHLRPYDKVFRYGGEEFLLCMPYTELTSGHDRIRELNEGLA
ATEIDIGKEKPIRITASFGLALLDPDVPVEKSIDRADKALFAAKSAGRNCVQIWDPSM
>A0A1J5RBH7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNPNTVIAMEPMRNPLRGNGLFARSDDEQEFLQEEWAFIGSRLRSLGIWGTLAFMLAAVT
DWIALGPTPDFFGIFVLRFFVLGLGLNLVRISSAAQAPEPASLAQALLVFEAAIVTIFLL
VVAAYGGTVEYHAITALLLVIALYAYAPALSSVSLWLGPAFTLLFLLEAVFVLHAQPKVT
SIMAVLLTFANFVGWQIAVQFNRMQRLNWLDRRSLRHEAADRLAAELRALDGEDSLSRVF
DATPVPMVLARQHDGRVLHYNEAAERLLDTAGKTRGGLVPFSSDFFSDPEQFAQQRRILL
RDGRVGPLDVRLKTTEDKPVDVMLSSALLQFHGEPAIITSLVEITARKTYERELQRLAHT
DPLTGLRNRRGFFAEASAQLQAARASGGALAVLLIDADHFKRINDTHGHGVGDQALRQMG
LAIQAALCETAVLTRVGGEEFACLIPGASLQRAGDIAERCRARVVAQELRCGEVTLQVSL
SIGVSLVLEYEQRIDEALSRADRAMYAAKQAGRNRVSLAA
>A0A0M6Y6W6|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MERAVVANLYGKGGVLDRVARPEMRVPFLLGLVVFLACIFGILTRPTGFLAAVWPANAIL
LGLLVRVPKSACWQSWVAAAVGYLAADLLTGATLEKAVLLNAANMVGVAAGYQVYKYLPA
SSVRLQQPLALLHLAVASAIAASLAGVVGGIANPILFGGGVIPGWIFWSTTELVNYISFL
PVILSAPKLEGTLPDFSGLLARLRQEKRAPLILLLISCIAGAVVGGPGAIAFPVPALLWC
GVVYPVFPTAILTLCIGVWGLVILSNGLGDSSSLQLDVMTLISIRLGISLVALAPIMLSC
VTQSRNALLVRLQYLATHDQLTDVLNRNAFREEVSRSLSLGMDGFALLMVDLDHFKSVND
TYGHAAGDTVLVSFVRRVQGTLRPGSLLGRMGGEEFAIMIPNSQIMDAVAEAEKIRQSVC
SEPVAAGDGKLVRVTASLGVVAVEHDNAACLDTLLAEADRLCYQAKERGRNRVEHCGAV
>A0A1C6J7F0|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MLTFTPNLADRFQGGGKRGFRVLDPREQMDLIHPDDAELLRSILNEAAEKPECQSQSINL
RFVDNRGVYCWMRCQVRVLTDVRGTPELIVGKLSDIQEQRLKEQRLIEKASVDSMTGILN
RKAADHQIAKSLSTSEKGFLFMIDIDNFKLLNDTLGHAAGDEALIHFVSEIKDSFRQEDL
IGRVGGDEFIVFMSNTDQEEAACIKAEHLLLRLAEWEKYALSASIGIASYPRDGRSYHEL
YKAADTAMYQVKERGKNGYYLLNNKGL
>A0A1C3HDP9|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MPLGTLCIIDSHPQPFSPAQLADLHDFAAVVEEYLQSIERLVYTENLKSDLQRTEALFEQ
TFSQAAVGMALVSLQGYWLRVNPRICEMLQYSERELMDRTFQDITYPLDLNTDLEKLQQL
LKNEISTYSMEKRYFRADGSIVWVQLTVALNRLPNGKPDHFISVIVDISERKAAEADLFA
LQHELEQRVEIRTRELNVVVKKLNEEIETRVLAEYQLSAEKERLRAITDNMPALISQIDG
NERYLFANSAYKTWFGLEESSLRGMTVRDFMGESVYRIAKPMIERALAGEMVSFENELQT
RQGLLMIHTTLVPCEAQGFYILAMDITELKRLQQRLEYDATHDILTGLTNRRAFLRRLSG
TLQACCHQRQMALLFIDLDGFKTLNDSYGHDFGDLILKTFATLLSTCAGERHSVSRLAGD
EFTVILWPLTDPRREVSEFCENVLAHLANITQIGPQKVRLSASIGAAISPRGDVTEEMLL
TRADGAMYQAKSAGKGTYAICEL
>A0A732D487|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAEKLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3E2KK31|diguanylate cyclase|EC 2.7.7.65|Citrobacter gillenii|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A6L7ENU2|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. Lac1|TrEMBL
MDKPLWVRKLRRVSGPGHVVNYCFVAVLFFSTLLIWREVAVLEEAYVTNQRNNLENVAHE
MDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHDPIWSVALHNRRTLPV
YGVSDAFVDSQSMLSRHDARTGNELMAALELGYLLRLVDENRGFNEGMLYISRSGFFTGT
TLPKNAVQAQARYTHAIAAPWFTRQSQRNNPGRGVLWQTVFDGHEQNDDPVVTASVPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRFNLIASSASGNVLTLLSAREQ
AMLSYAFSHQNQGSIRLLTRYISWQKLNNFDGVLLRTHTLQEGVRGAFGSITIALTLMWL
FFTLMLIISWQVILRMVRNMSVMQKSLEWQAWHDALTRLLNRGALFDRAIAITRVCERTA
RPVSVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCIVMPD
TTLQMATAIAERIRIRIYNREILLCNDTSLRISASLGVSSSDDSAGFNFESLQSTADRRL
YLAKQNGRNRVCFNDLFLRDGMGK
>A0A1Y6MJ14|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MSKAEQHILKNKTSKWQLDHILCGNDMIRRCLILFFNLMLLVIIVGFSLRQEINETRLYI
EANLNQIKNTTDSLAYRNKRYANTATKAIANMDEYNKRLQVLAEIHYYPKLKEFGFNRGI
YPNNLFNGSLVGPGFPNQLIQKDTHLFAVLDELWAEQQAHPIVYNYYYISHLLKYFYLSS
KLPVDKFNTTKEFFSTDLYRNQSSISQSLDELQKGIYYTYPYLDFFSQEMVVTIKSPVYK
NNKIAGDIGVDIPVKSLIKSITLPKKLKSSLNFYLYVKDKKQKIEIYNGYNNRILPSIPV
YTHLNNNILIFADISPWFFVNFAIKITILGLSLLIILNYMNALLKRHKFQKQRYQLEAYT
DLLTGLFNRRVMDTIIKDIVTENNKNGQPTALIIFDANDFKIINDTYGHDIGDLALKHIS
STITDMTRDSDICIRLGGDEFCIVLPSADLEKALIMADRLELAIFSGYFCHYNIKISIST
GCTVIEKNESLHNALVRADKILYKNKKNKTENKKALQKQLNNYIFKSPPNFPKKE
>A0A150I0G6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter venetianus|TrEMBL
MFRVDSFRNRLLILFAGMSFILGLCITLYIGKTASAQMSKSSGQTLYIAAKSISNTLANS
LTEREREMVLLSQSPFFAEADFQNPRVQQQLDQVKTSYKYYAWIGIADPDGQVAVAANQL
LQGADVSERPWFIHGSKQVYLGDVHKAVLLAKKIKAINPNEPMRFIDFATPIYDPHTKKL
KGVLAAHADWSWASHVLSSSLSENAGQRGIEVFIVNQQGEILYPFKSIGQVQPPVSKKHK
ANYFVDNWSEDQQYLTTDVPVLSQTQMNLGWHVIIRQPMSIALAEVKSLQHKILAIGFIL
SLLLLLLTYKLANRFSRPIETLAQSAHAVEKGQEDIRFETQTSIREIKGLSQSLQSMTDT
LLTQKHQLLDANATLEQKVAERTHELQVANVELAHIARYDALTGLHNRRAFNDYLSYLFI
QMSRTEQTYAVLLMDIDFFKKVNDSFGHEVGDKVLQRVAEILPTSLRITDFVARLGGEEF
IALLPATTLEGAMHLAEKIRSAIEQESIIENHPVSLSIGVSLVQLDDTDMNDAIRRADQC
LYRAKQQGRNRVISSITDATDCLA
>A0A2X3J9P1|diguanylate cyclase|EC 2.7.7.65|Listeria fleischmannii subsp. fleischmannii|TrEMBL
MSNQFDAYIDSISTFLAILFIQGIVFRKLREVKPNWFLNHRTVLLLNILLGIYYGLIGIY
FIWRGELDSATVIYTNMRMNILLITAIFGGRVPVSIAYSIMVLGRLLLGDSSPHDIKFIL
LLTGFFLICFIVTNFKLNLLKKYVIVFSCAIPVLAYYYFTDFGSRTILSYGEAIIYYFLF
MVTSALLFAASNYIDKSNKTMFQLRNSAMTDMLTNLPNIRYFLNTFEKYFLTSSKKRRPL
SLIIIDIDHFKQINDLHGHQAGNTVLSQFSAILKNHFLPKQALISRIGGEEFSILLPNIT
LSESTQIAEIIRSEIERAVFPYNPKSGNVTISLGVSCHNDLNVFYKTKENLFEAADQALY
SAKQGGRNQVQASKKEA
>A0A1E3AU00|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKRLLKGLSPEGEALLNLIPGGVMQCRNDSSYTIVEVNDGFLSMFGYTREELDERFQNRF
FQMIHPSDQQNFLIEAERQLEKGDRLSLSYRVLCRDGSYKWIASSEKLFGDEKEERFFCI
FLDLTEVRDAQEKLRLSLEHLEIIMNQSSDIIFEWDLIADSISFSPNWLEKFGYAPHYDG
RQQKEEMLHNFYPDDVEPMAAFMEEAKRGISDSVIDVRIRSFQDQYIWCRIRAATQYSAE
NTPIRAVGTISDIDEEKRMVEELRRRAELDALTGLYNHTETERRAELYLADKPDTICAMF
IIDVDNFKLVNDGQGHLFGDAVLAELAAGMKKITRKSDVIGRIGGDEFAMFLKDLPSVSI
AEDKARKLLQLFQNLFQGEKQSVEVTCSIGVAVYPWDGSSYQELYHCADLALYQAKCWGK
NRFARFDAGSMAAMDRIGYSSLGASIDSDQNTGGKTGDLVNYVFQILYDTNDIDDAIKTI
LEIVGRRFDVSRAYVFENSFCGNYADNTYEWCNEGIIPQKEFLQQYPYEKVEGYKDLFRD
NSVFYCRDIHSLTPAQSRLFESQGICSTLQCALYDDKEFCGFIGFDECTGLRMWNKEEIG
ILSLVAQMLTTFLSKKREADRNRQILVQLNTILDMQDAYIYAIRQDTYELLYMNQKLLRL
DPSARPGMACHQAFYGRSAPCENCPLTGAMEVYNPQYGIWAKVQFSPMKWGDDSAYLINC
ADITEYKRMQEKKGSGR
>A0A732GTV9|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1Y6MBG8|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MTNDLYFKYQPRYYDGEISSYEALLRSDINDFNVEKFVYSIENSAAFDLNIIGKVLQDRK
SLHICDDVSISLNISIASLLDDVFIRKCLNIFEHEKNITLELTNHDQTDDFDGIQKSILL
LKEQGVNFALDDYGKGYLNTDIFLYLDVDYIKLDRRLIRNIEHNYISYSILKSKYDHIVN
VLDKVVIIEGIETFEQFNLVKEFGDMFYQGFYFSMPINIYDIEKTRLTKYRVKNERIQFS
LQLDQAIFDLNRSQEPKNVKQAIDNIKRIDKYNIIGLTSNTFDLYSERHRINKNYREIIK
NKKHSHYMLAASLVCGCDGAVVIRDVDGNVIFNNDHFIRFMGVDLVDMPIDQVCEQVTDY
RTTLHVESELLQSDSCFMMSDEVMKTKNGMELVHVYRQKVSHFGQNFVVCSVYEAIDTIV
IDELTNCYQKNYLSSSYMKQHKILVFIDLDGFKAINDNLGHCIGDEILRDFAQTLKSMLR
DSDVMVRFGGDEFIILLNSHVMTTVQQRIVQLRTDIEDYFTQKEMKLSFSYGVASLQNGV
EAALKQADNRMYQEKSFRKRKLDIVKLA
>A0A6N3QT21|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIVAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A378KVW6|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MITVLGYELHDKMRHNHNIDTYHALRLKDKRKVLLKIPNNNYTSSENLAILQHEFHLLKT
INAPPIIKAYDFLQNTPAPVLILEHVEGQLLSSYLMENTLEIGDFFDLALQLVDIIGELH
QRNIIHKEIRPSNIIIDTQNLTLKLIDLSASTKLSEESFDYSNLDKFVEGLAYISPEQTG
RINRPVDYRTDFYSLGVTFYEMLTNQLPFQTSNSQELIESHITKKPITVLAVRRNIPKML
AAIIDKLLEKMPEDRYSSFIGIKSDIVDCYKQWVIKRNVSEYALGTKDIRDHLSISRNLY
GREHEVKQLIDAFKRVCKATSEIVFIAGYSGIGKTSIVREVYKPIIEYRGYFIQGKFDQL
RRNMPYSAIVTAFQNLVKQVLAKQEGTLEVLKNQLLHSLGTIGQVVIDVIPEVELIIGEQ
PAVPQLNPVDAQTRFNLVFQNFVRVFAKAEHPLVIFLDDLQWADNSSLGFIENLLQDRET
QYLLIIGAYRDNEIIANHPLQLSLNHLSASHVPFTTLTLHPLNLKNVQQLLHDALAGSFE
RVQSLAECVYEKTQGNPFFINEFLKLIYQQQLLTFSYEQSIWEWNVEEIKQQSADDNVIN
LITAKIHLLTKPGQETLKLASCFGHQFDLKTLLITNGQSASNTAEQLWQAINANLIIPLE
ESYKTLGLVGLNGALSDLDLGNLHYRFAHDRIQQAAYDFIEAQDRPAIHLKIGRLILKQK
PLEEHDERLFSVLKHFNQSITLVEDIEERHVLAKYNFWAGQKAKMESAYDAANEYLSAGV
DFLEPVNWSKNYNLTFQLYKECAVCKYLLGDFITADLYFSELLNHSRCATDSLEIYRLKI
EMFSVLGKHTEALQMGLTALRQFNIKIPEKPNVLHILIAIYKIKFQLRTTKIEELYLPPM
SDLQQKAIVDLITQLLNSAFIINQKLFVILTCKNISLSLKYGYTESTSMSIPVYAFIIMH
SLNLYDEAISFVRLYERLKQDYGASDFEGKNQFILGTFIEPYQTSFEQCNSTVNKAFRLC
CDVGDLVYSNYSKLLLVLHSISAGNHLKEVKKNIGSALSFMNRVKISDFITVAKFWEYSV
QCLEDSELATMDKSAFFEEEIQNGKSKTELSFFYSTLTRMNFLLGNYEDAVKSGEQHEIF
AEYDKGLVSHLDGKFFFALALFSYFPQLSKAKSKFYLKKLKRLALFIDKYASWCPDNYKI
YSLLMASELARLDNYEEKSLALYEESIKLALSRGLILIAAIASERAAIHCLDLKIDRVAK
FYLRNAHRYYKDWGALTKVKLLEEAYPTLLLNYYNSSYETGVSDTPYPLASTKSLDMLAI
LKFSQLISGEIRLDHLLQKLLVIVLELTAAERCVILTKVEEQWVVEAEGNLVHQTVYLNG
LVAADTSQDYPKSILYYVERTQQPLILKDASQSELSSQDVYVIEKNPKALLMMPLFYKGQ
YSRILYLEHKGMNSAFTPEHLNSLHLLMTQTMTSLENGRIFYEVTHDLLTGLANRNMLYE
LFQITVKQIARTQGSVALILLDINHFKSINDDLGQDVGDKLLIHLASKLTANLRRGDISA
RIGGDEFVVMFANVPSTALLISIVERLIKELIAPVQIKDHVIHLSVNAGVSMYPQNGNDI
QTLIKLAELALNQVKEEGANRFKIYSANRYDELNQNPGDTAQ
>A0A090NH59|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGRNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTALCVTVRKLSDIFIHSER
FKCNVFYHFMFEEKSYFLN
>A0A0J6ZBS1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MTVRRKGLPMGFAAGLQRRMLLGYLAVLLALYASVAVSSWDLASAFGERISAVLCLLGLA
LAVRAPMGGARYVLALLCLCAAPVAAMPFHVYDSAQVWAVIPAMFSAIYIRAWHRPVPAR
AAAAGIAAATCLGLAVAPAPAPWGWYGMFTVCIMASAEIVGVLHATLYEAALRDPLTGAW
NRTGVERHAAELMARAARRSEPVAVIALDIDDFKGLNDRAGHAAGDRALAHLVRDWGPRL
PDQAVVGRLGGDEFVVVLMGHDASRAVDLARDLASAGPVKVSAGTAVGHPVDARSLEALI
ARADRDLYRVKRERKAQSDGSAVDAQREE
>A0A0J6ZEZ3|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MTPGASPIDGQSPIAADNQPPHFSDSDYVRGMTRLTDVIQELSLSRTASEVQRIVASTAR
EMLGCDGATVVIRDRDMCFYADEDAVTPLWKGRRFPMEACVSGWVMVHKQPAVIPDIYAD
ERVPHDAYRPTFVKSLAMVPIRRRDPVGALGAYWAQRRRPTQHELALLQALADVTSVAME
NVRAHAVLEQQIEERPTSIDVAMPSAAAPGGLDATFAAAFANAPIGMAVIGLDGSFQKVN
REFCRIAGYEPEDLTRLTFQDITHPDDLDIDLAEASRLLAGEIASYQMDKRYYSRDGHVV
WVRLSVFLVHDDSGEPQAFISHIEDISARRRDEELLRRQATLDTLTGVYNRNRFEEELRR
YKVRASRHANVDEAAVFMIDLDGLKQVNDQHGHSAGDAYLRNVADIISRRLRLSDVLARI
GGDEFAVLLPRTTLAQAQQMAQTLVERVEALSPGTICIGIAMLTPDAIDEALERADRAMY
RAKRQGGSHWCGPEATPVVSEESTRSPGSPASSASGTR
>A0A8B4RYV7|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MTDASAPKPTPMLQTAAPRTWAAALGLGSLVFLAALLGILGRPMGFLSAIWPANALLLGL
LLHRPDWLRPSSVLAVSVAYIAADLLTGSRLDVAILLSIANMAGVGAAWALMHRQRHATL
FMQRQSSALLLFVGSGLGALTAALLGAPVLSAVFGTPHWQAFSMWLSSEWLNYMMFLPIV
LAWPTRKQPAGHLGESSPLRRILPLLSVIALEAISYWIKGPGSLAFSLPALIWCALSYRI
FSLTLITATLCLSSIIFISLGTLEFTPAHFLEALSFRVGLCMLVLGPLAVAGSHMARNEL
MQKLSHAVNHDFLTDMLARGAFMKQGQRILERCRQDGQPFAILMLDLDHFKQINDSFGHA
GGDQLLRSFSQTLSQVLRAQDIVGRMGGEEFAVALPKVDATAAQEIAKRINRSIRELRVP
MNDKTMSATVSIGLAHTASLQAHQSLDLLLQQADQALYEAKAAGRDRVAAQLR
>A0A6N2YG12|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MFRIKDSDAMLHNLIDQSAAAFFDQYRFVTPADYCVYNCKNACLEAEDIPCYAIWQRDTP
CHNCSSIRALSLKEPVIKLEYLENKVFLILSTPHTLDGRRCVLELAKDVTASLMINDDRH
CDNTIITDVIAELNNLSVRDLYTGLYNKNYAESEVSRCINEKKSFTAAMMDIDDFKIIND
TYGHQTGDIVLREMASLLTDAAANGKGWAARIGGDEFILIFPSLSLEQAEPVLSALSRDI
KEHLFYKGDSRFSINASMGIKEYHPGEMNAADFFDQVDMRMYAEKRRNKSGR
>A0A2U3Q7G9|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium vignae|TrEMBL
MVTEQDRRVIASGMPMFLEEHLLEVGEGRDRVVNSRKMLIADGDGNPQYLVGVIEDVTER
VTTRQRISHLAHHDVLTDLPNRSASNAALAERLKRAGEAATSFAVLSLDLDRFKEVNDVF
GHPVGDLLMRAAADRLATEAEGAFVARIGGDEFVVLMPEDARREDVLVLAERLVETIGRE
LEVDDYLSNVGLSIGIAFCSRSRSTRSSSRFQASASAIWNLGLTTKFKCGGAANLLHNRH
RPDANQGNNPSKRGRVSWRTYVATGRWRPSVASRRPIGRSRIGNCSAEPNISNISPKSS
>A0A7L6CLQ5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00994|TrEMBL
MQRDTYVVKRSFLQWLQKQSNPGRIVNLCFLVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDRQLQFNVDKLLFFRHSMRDALQTPLAFGVLHDAVFRFKTVRNTPFWQLAVDK
DRTLPINGVSDAFVEKTTLLSRDDERVNNELSAALELGYLLRLASSSPQREERVFYISRA
GFYLSTDTTSQTVDIVSRYYRFVTQPWFTQQSERENRSRAIRWFVSPPTAYTGNAPVITA
SVPIYYDHYWYGVVAMDFALTTMKRFLMDAMDDHTEGEYQLYDSRLNMIASSEPSVRHIN
RFDEREMAQVAHAIESDTQGEIRMGTRFVTWERLDHFDGVVLRIHTLHEGVRGDFGSISI
ALALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRDALFERAKILA
VQCQEKSLPLAVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIASGLRSNDVAGRVGGEE
FCVVLPGITLEAAAGIAERIRARINSKEILVKKSTTIRVSASLGVSGSQEKGHYDFEQLQ
SIADARLYQAKQSGRNQVVWHDHEKK
>A0A8F8C3L0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MLKASLRSHLTLWFAGLSLLTLVSVGFYVGHIATEQMKQASGSALLNTARSAATLLGDQL
RERQLEVYLLSRAPHLERGDLDNPAILKSMQLRTQARAEYAWMGVTDAEGHVHQAVNNLL
VGQSVQQRPWFQAGLRGEYTGDPHEAVLLAKLLPGTPNGEPLRFIDFAAPIRNADGQVIG
VLGAHAHWSWVTRIVESAAFSHKNASPDIEALIIDHDGKVLYPEALMGQQLAVNDSKSPG
WSVGNGYLTSMVTVPTPSSTALSWSIAVRQPLDTALEPARLLLYKLLLLGVAAAVAFGLV
AYYLAQYLSRPIEQLAHSAKQVQNQQPGAHFPLQHPVREIAQLGQSIDAMTQSLLAKERE
LQEANASLEATVAQRTAALMQANAELLNLATHDALTGVYNRRRFDEKLSEYSLLFRRTGR
PFALLLIDADHFKRINDTYGHAIGDDVLQQLAQLIQVSVRATDFVARYGGEEFAVLLPEV
AQPDTPEVVAEKIRVAVALAHFPNIGQVTVSIGVALADPADNSHTMLIKRADQQLYQAKA
AGRNQVA
>A0A6C0Q4T0|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. S4.7|TrEMBL
METESEPYVRLATLRQLHDVVGELNTARSLADTLQTVADGIVKGLGYELACVNLVQPDGD
LVVAAFAGNAAAEALITGRVGARASWERRLSMGETWGELRYIPHTEGWILLDDDVPQWYT
EGPDPRFEDEWHPQDRLYAPMYAPGGGRELLGVISVDRPRGGRRPGPWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
TNDALCRLLGRSASAIRRYAFSDLVHPEDIGTLLRTSAEGGRAELRLARRDNSYVWVSLR
NSVVADTTDGPRFLLTHVEDIEERKRNELQLAHRASHDSLTGLPNSAELRARLSARLCER
PNAISVRETAVQTVDKAFGGYEGANGAGSGGGYDEGGHGTGVVPYGQEPGYGGYNGTSGA
GYAPVPAPGYGGGHGGAAGGYDPGYGPYEPYDSYDSYGDPAERAFPRDGFDPSAAPVPLD
HHVHTVAPGADPDDGSKGLAVLFCDLDGFKSINDRFGHNTGDAVLIEVARRLNTGVRDGD
TVARLGGDEFVVLADGLGATDAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWASCGMT
VEEVLKSADQRMYIEKRSRSKVQRRAG
>A0A7W8K6N5|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. K2C7|TrEMBL
MPEFSSRLPQHEPALTEFKVSVLLIDDQLIIAEAIRRMLSDQQDIEFHYVTDATQALDTA
LRLQPTVILQDLVLPGTDGFALIKLYREQEALAHVPVIVLSAKDDPKLKAYSFAVGANDY
VVKLPDRLELLARIRYHSNAHISRLQRDQAFRFLRESQKNLADANIELQKLAALDGLTGI
ANRRRFDETLHFEWQRGQRDKAPLSLLFCDIDHFKSYNDQFGHLAGDLCLKKVAAVLTEH
LKRPADLAARYGGEEFALILPETELAGALQIAEACRRQLEGLQIENPAAAARIVTMSIGV
ATVVPSPKSTVEALINRADQALYTAKRGGRNSVLSAEETGD
>A0A857JFD1|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MTYFHVLRKLSVMALNIGAHFRLLSLLLIGFGLFSHSVSAQPLDRCQLLSDNNKTKVSDL
TLAAALSLPVTQFDNLFSFQCSLEQPRVLMTKDGFIRHSVLLINGVEQSALAANQLAYAL
PQGNFKLAFQIDAEKDFTASLRLQSWRDYALVGQQHNLLLGLFFGLCITLVFYLFFMGRS
LNDERFHYYCYYVLCAGVFFLLQEGNLDLFLNGSSFNNRSVNLLFAGLTVFSGTIFVVAL
LDLQRRWPRFTRFTVVYPAAFVLAISIALQFIARGQLFSWLSSVMSIITMLLMLCTFALI
GYASYLRVHTARLVLLASCIVCCAMVFRLWFGDLSPFIERYGLIYSFAIESFLLAIATSE
RIKRINNDKIFAQAQAMTDSLCEVLNRRGWENAAQKMLSEHQANGGVLCLLYIDLDNFKQ
INDSFGHKAGDEVLQIIAKIIRKQMRDQDAVGRLGGDEFVGLARFEDESLPMALKARMTQ
RLHNIKISTDSVQIKVNASVGCVTFAHSDISVSDMLHKADHAMYIRKRENQSTI
>A0A7G8QM03|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. JUb54|TrEMBL
MNKELSQAPRPTFKRALRRISVISVVISMTLVWMLLSTASVFTLKQYAQKNLALTAATMS
RSLEAALVFDDSSAAEETLATLGKQGQFSEALVLDNQQNRFAVWQNTDLVRHEKLSGIIS
QWLFPEPTRQPIMHQGKVIGELRLKALDSMIGHFLAISIIVLTGSILLASVISLLLTHSL
HHGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRSSLHDPLTGLANRAAFRSIIMALMKDDTARQRSALLFLDGDNFKLINDNWGHAT
GDKVLIDVASRLMAFANKRHQAWRLGGDEFAILLRDVHSEAEVQALCATLSALFLEPFNL
HNGHTATLSLSIGYALAWEHHSAESLQEFADQNMYRKKHQRIQQVQN
>A0A857JPX7|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MFRAKLWANELDYRRTVLKVVLCIIIFAGSIFVVNNWLNGFKVYALIELAVVLFSVGLLA
IHKKTPNLTLWSSLFLFAVYTVILIGIFTVAFKAALYTWLFLIPVLSYLLLGITLGNLFT
CVYVITGVVALCKALFSDSSEIPLISVVNISLCLSAIWALSYTYESKRASMVKRLQQMAS
LDPLTGLHNRLLLDSSFEMLCESLPEQHQTMSMLLIDLDHFKKVNDKYGHDIGDKVLIEV
ARLINETRRLNDWAFRLGGEEFCMLIPDTSEQQAQNIAERIRLAIEKDIMIKNEDLTISV
SIGVSHWPEDGQTLNQIYKLADERLYRAKETGRNKVIAR
>A0A5X6ERQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Aqua|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVVSLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2S0I4V0|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MSSSSTGVPPAAPANAAAANAASGHDCYLSASNAQAWEAVYQSVDADTRGLVAAVVSDHA
TQLVDAFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVRDQGDIDVLLATQKKV
GEVHARVHIPIHLVMAGARILKNEIAQRLHGSGLDGMAVSMATQYVCNLFDLAIEQMSRA
FMRDINRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAA
SEFGLWLQHKGAVLFESAPALRQITEAVARLDDAVLPRMMQGGGHEQESLPDQVRELQEL
VARIKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIALAQRQRSSFSVLLLDID
HFKAINDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAALAAAE
KLNAEIRRHRFMMAESGTLQVTASIGVATFDGHPDYAYLIDRADKALYKAKQAGRDRSVE
A
>W9VKL9|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MIHSLPTFNQDNSLEWQLNLIQHLDVGIVVLDKAFTVRLWNTFMVNHSGISAEHMLNAHL
FSKFTDLPEDWLRRKIQTVIMLDNSAFTTWEERPWLFKFKSYRPITGSARHMYQNATLLP
LKNAQGEVDHVAIIIYDVTDAATNRLSLLNANQELSRLSITDQLTGLSNRGYLESCIKSE
FERFCRTQQKSSLVMLDIDYFKKVNDTHGHLVGDEVIRKISKCITMFTRTTDLAGRYGGE
EFAILLINTPIGNAKIFAERLREAIENTVIQVDNLDLYVTVSLGISVSDKGYTDYNQWLN
DADQALYRSKERGRNQVTLADYD
>A0A448C1X7|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MVGSQVRVTLSLIAPTLVLIFGITFVGIWCVYRRRTYLLHLATGCALFAAGAVSQILYVP
RDSGANALVSGMLYTAAVCAATQGILNRVGRGLRWRAYAVFCAAIMVALWYFFYVDRNLL
VRVYVLNIGFGGLLCVAALRMRSAATGRRIDTALFVVLLAFGLHFLPRTLLSIGARAPSG
PLAFADSPFWQWLQLSLAVFSVGLAITLLLAIAADTIEEVRHEGEKDWLTGLLNRRGFEA
RMRPYQNGGPDPAALIVCDVDHFKRINDEYGHDGGDAVLKNVARVLALSVRKRDLLGRIG
GEEFAVYLPATDFQEALHCAERLRAAVADTVRAPDLATPVTMSLGVAAAIGAENWESLFR
RADENLYAAKRAGRNQVAA
>A0A0A6ZS47|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MSVKLRLPHCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFT
VSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5P9D8S8|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. THAF82|TrEMBL
MLELGEKLTNLTLRYMLRGRRSGVGRMGISLTRDLLGKTNGAVAASIVAVACFLVGIAVT
AHVGQLVRNELVSQHKREVIANLSEVHARLEGELSRTVAYGFGLRSVVSQDTDAPFDMAD
YREIAIDLIEENPSIRSIGLAPNNILRAVYPFEPNQAAIGLNYRMNTAQWPAIRKAMLTR
EVVIAGPLELVQGGRALVIRIPVFPASFPGQATKDRPYWGVVTLVLDEAGLMASAGIRES
VDGLRMALLNKNAVNSQSAVIFGSAAIENLDFVSLPLHLPGGLDWELIAYPEAGWSNMGN
KVWITQLVGSFLSLVFAAMAFLLISEVYKVRSMALHDPLTGLANRRLLEDRMMQLAAMCE
RSGSGFEIFYVDLDAFKPINDSYGHSVGDRLLVEVGQRLQNQVRRTDTVARVGGDEFIVL
TPGNMRRQERKSFLTRLSDHVSRAFEYSGARIDVKASIGTASYPGDAATVEDLLRVADGR
MYAQKAKTKQNSQDAPKKGVIQAG
>A0A1V5BGL1|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin035|TrEMBL
MEVAHIHDFTRIICKSSRGIIYIAALIWIIRYICLHRTKIKKAVWVSFAGIPMILLGMFL
DLWGELHPMPHLIKEIVGEIILTDIGIALILGSLIQLIEEISQTSRKHQRDAETDPLTGM
FNRRVFFAEAERVLNKARVGKCKPALAIVDVDNMKDINDTSGHQLGDAALKLVAQAIRKS
IRECDVAVRYGGDEFVILFPEKGPYIDTIQARLQKNLETSLIETWDAPLTISVGLADFPA
DGKTVDELLRIADARMYAGKNTKKQ
>A0A2X5BK49|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MLSKHGLPGAVRLVNLFLLVFFLSLVGIFSRPLDSLSLFWPVNAILLGVLLRKPAYASPA
GWLVTYIAMIAADLTTGEGWMLALWLNLCNMSLVATGYCVMRLLPQSQRRMGNPQAILYL
FAAGLAGAVVASTLSILRNDSLYNNTVLTAWLAWFSEQFSTTLLILPVLLAAPRLKTLLR
MQYHWNLSDGLPLLALLGSLLFSIYIGGPGAIAFPIPALLWCAVRYQLFTVTLLTLLTGV
VEICTISANVMLYETPTSRGALLDTLMSARLGIAMLVMGPLILSSSMVANRKLVRRLEHS
GNHDFLTGTLTRSALTRKARELLEHKRRSKEAVSLLLIDIDHFKLINDTHGHIVGDRVLT
HVTHVLRRELRHDQPLGRLGGEEFAVVLPRALAAQAVALGEFLRQQVEKSEVKSGHKALK
VTISVGVASLAMKEVKSWEQLMNMADIALYRAKSLGRNRVESFNVVSGSSVDHIWFKE
>A0A0G4JMY3|diguanylate cyclase|EC 2.7.7.65|Pandoraea apista|TrEMBL
MNAPNTDKYDLESEYEALLSFMYLSPVGIVRSDKSGAVDMMNPLAAQLLMPLISGGSIEN
IFDSLASVAPELRNLVASFEAERGPVCENHRILVTPAKDDAVVLACSIIKVSADVLMMVL
TDISRQVAAERRARQTESWLAGIYTSVNDFAYFTLDAQGCIDSWNSSIERLTGYEAADLL
GHMLSRLYADDEIVLHCSPEHMALTRDDGWHVEEFWCKTKSGRRYWGQLLVAVLREEDGE
VSGYSAVLRDITERKINSENLARLLTTDHLTGVTNRAHFFEIGESEVARAKRNGRTLSLV
MLDADHFKRINDNAGHQAGDEVLKRITEEARALLRRSDIVARLGGEEFILLLPSITSGEA
MTVAERLRVAVEQAIIETAVGPLSVTISLGVASLGDENHTLQDLLAAADHALYDAKQAGR
NCVRGFAVQAEDAANFLGK
>A0A4U9HAV6|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MLYETPASRGALLDTLMSARLGIAMLVMGPLILSSSMVANRKLVRRLEHSGNHDFLTGTL
TRSALTRKARELLEHKRRSKEAVSLLLIDIDHFKLINDTHGHIVGDRVLTHVTHVLRREL
RRDQPLGRLGGKSSLPYCRAHWRRRRWR
>A0A653JKS7|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. 109|TrEMBL
MRLFVAFLAYLCLWSPALAEVPMANRLCTQSSAADVTAESLLQSGNAFDCSDSKYALDGP
RVWVKIPFLADRLPPGSVEVQGDNNGLTTMQVHAQLDDGSLISSSFSEQQVIDSWRPKGH
YGLPVPGSENPELRNRITHVYIAIDNPKVVSSMSLIQLASKDKWDGLKLPLSIMFGVLCG
MVIMPLFYHIFFYAALRYSFMLWHSAMIAATVAYTFSSSGLMFLAFPETSLLAKMLINYW
ALAIAVAASGFFLIRFIEPGKIAPWLRNGIILSSVLPVFVTAFVLRIDEGYDMDARNYYH
ASFLPAFFIVLYAMGHALRRGSKAIWFQIAGWTPIVFFGLDRVARGMDLYIGWPALDYGL
YFALVLETIILALGVANRIWLLRQKHENTLRKQVELTLLADTDGLTMMNNRRSFEREYRR
NQRDRRYSHLAIIDIDFFKRVNDRYGHEVGDEVLRVVGRQLDGTGHFAARIGGEEFTLLI
KDKGRDKRRNYPANVLTEICETLIMAVHEEVPEIREPVTFSVGVASLGRRDSLRSAMATA
DRRLYDAKKNGRNQIVWIDISSSGPVKPAGTASV
>A0A7Z9BYY7|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MQQEDALILNHDLMKIEQEFIHNPGRIQPHGLLLVLQEPDLKILQVSQNALKLFGVSFST
FLNRPLSHFLNKLQFFQIQDCLINNNFQSYNPIHLVFHIKNKKIICEGILHRNQDIVVLE
LELTQDQNVTFVNFYHLVRVSVCKIQSATNFQSLTQFLAEEIRKISGFDRVMVYQFDQAN
NGIVIAEDKRQDLESLLGLHYPHTDIPRFYRELYKQNWLRLLVDIDHEPVDIIPAINPVT
QKPLDLSFSVLRSVSPCHLEYLRNMGVQATLCISLIKKDRLWGLIACHHYSPRYLSYGIR
KACEFLGQVMAVELPYKEVSEDYLYYHEILKLVRKNLLNAPALETSFIQSLVQDKTNLLN
LVKAQGAVIRFGEDLMLIGQTPSLTEVQQLITWLSQYCHQEVFYTDCLPALYPKAASYKD
LISGILAISLSPNQSEYHLIWFRPEVIQMVNWAGNPQHSLEIENPGVLRLTPRQSFELWK
ETVKLKSLPWKSVEIETAQELRNSLMLAALESSEYQLRQSKELAQVTLQSIGDAVITTNN
QGEIESLNPVAEELTGWSVIQAKNLPLHDVFKIFDGITHEFIENPVKTVLKEGCIFDFSD
NVILRSKDGKERAIDNSAAPIRNRDGAIIGAVLVFRDVTQERELSQRLSWQACHDALTGL
INRSEFEKRVKTTLQLMQESPNHHAICYLDLDQFKIVNDTCGHLAGDELLRQLSCLLQTQ
VSERDTLARLGGDEFGLLLNYYSFDEAQKKALDLCNLIRSFRFIWQEKVFSIGVSIGLVI
IDEKTSDLATILSAADAACYAAKNQGRNRVHLYQADDQDLIQQRREIRWAAQIPQALEED
RFCLYHQPIVEVNTTSKQHKHGEILLRLRDTSGQLVSPMAFIPAAERYDLMKSIDRWVIR
TVFSHLEKHHQSLNLTTNAGETEEFYAINLSGASLNDNEFIKFLYEQFKVYQVSPKMICF
EITETLAIANLKKAVQLIQSLKLLGCSFALDDFGSGMSSFSYLKTLPIDYLKIDGGFVRE
ILTDPVAREIVEAIHRIGHVMKIKTIAEFVENDAILTELKKIGIDYAQGYGIGKPQPFIL
PVIKTGRETDWNRH
>A0A7Z9C0I6|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MNKIKVGILYSLSGTMAMSATPLLEATLMAIAEINAQGGILGHEIEAVIEDGASDIFVFE
NKARKLLEIDQVATVFGCWTSTSRKAVKPLMEEFNVLLWYPVQYEGLECSPNIFYTGSCL
NQQIQPAVSWSLKNLGKRFYLLGSDYVFPRTAHKLIKSLLKQEGGTVIGEQYFALGNRKF
SDIIDEIKQLKPNVIFNTLNGDSNFDFYQAYYEAGIQPSELPIMAVSISESEVHNMVQAG
VGHYACWSYFQSLNTPHNQEFVNNFKALHGIERVTSDPIEASYFQVYLWKQSVETANSFE
TDAVRKAAYHQTFPAPGGVVKIEANHHLWKNCYIGQITKNGQFEIVWKSPSLIKPLPWLG
VEELKNFPQADLVIDMLAEVSQGIQHSCLLEANSRRLELTMKQLKTEIEERQRIEITLKE
VNLELKYMAITDSLTKLANRYWFNECLKSLWNQHLVNQTSLALILCDIDYFKNYNDTYGH
QKGDDCLQEVAQAIKKAVRNGFDIVARYGGEEFAVILPQTALFDASQVATRINIEVQQLQ
IPHLTSLAEPYVTVSLGVSSQIPTLISSPELLISESDKALYKAKNNGKNQWCLHYTSEQG
TGGKRETQV
>A0A7U7G9D7|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MYKASSSLTQTSCLLPVIIKMAGGFMGIMLILLMSIFLMGNAVAAEKVSLQLRWDHQFQF
AGYYAAQWQGYYADAGFEVEIRSAIKPDGTILSATQEVANGNADFGVGAADILIARDQGI
PLVVLASIFQNSAAEFYAKEGTHLQAPVDLLKLRVARIKNDLIDIELQAMLRAEGIDPNQ
ITPYPHEPGIDHLVTDRVDVIPGYRISTPYAFQQQGISVTTLRPINYGIDFYGDSLFTHA
RWIERDPKAVQRFVQATLKGWAYALEHPIEIADKISQDLPRTETIAHGTFHELNRFQIDG
VKTLTLYPLLDVGHTNPNRWRRMYELMRTIGIITKPMAIDELIFDPARQEHNREHNIHRQ
LQTALYGIAGLIILIFAWNQTLRKVLTRKTRELLGVNQQLQDSTLRLKMATEAGKVGLWD
WDLGTNEVFYSAEWKRQIGYQDHEIAHNFMEWQSRVHPDDLDRALRTVQTYIEKPWPNYT
VELRFRHKDGSYRWILTHASLIQDAQGKVLRMLGSHIDITERKQTEKALRRSEEHYRAVI
ETSPDGFWMLDTQGHLLAVNEAYVRLSGYSRDELCTMTAADLEASENPAEVAAHIKTIIE
QGSDLFQTQHRAKSGRIWQAEINAAYYRYPAGDRIFSFIRDIHRRQRSEALLKVRMHLSE
KARSGSLDDILRAALDVMERFTGSQIGFFHFVDPDQETLTLQSWSSHTLNTMCKAEGKGL
HYSISQAGVWTDCIRQRQPVIHNDYASLPHQKGLPEGHAPVIRELTVPILRNDQVIAIIG
VGNKPEDYTSDDVAAVQVLADLLIDAVERKQAEDRIEHLAYHDALTQLPNRVLLTDRLQQ
AMAQTERDQKRLAVCYIDLDDFKPINDTWGHSHGDQVLMEVAQRLKASVRAGDTVARLGG
DEFVLLLGDLADVEECEHALDRVVTALRVPFTVSGQLLPLTASLGVSLYPDDHADPDTLL
RHSDQTMYAAKQAGGNCYHWFDAEYDRRSRHYRDSLHRIEQGLVAGELRLYYQPQVDMRH
GTVIGAEALIRWQHPDEGLLPPARFMPAVEASDLAIAVGQWVMNEALRQMTIWAAQGLRL
PVSINISSRHLQQSDFVAELQAALAAHPDVPAHGLELEILETVALEDMAIISHLIESCRQ
LGVRFALDDFGTGYSSLTYLKNLAVHLLKIDQSFVRDLLVDSEARAIVEGVIGLSVAFRR
KVIAEGVETDAHGSLLIRLGCDLAQGYGIARPMPPEQLPAWIAAWTAPSAWIGMANGERD
LDIPA
>A0A2G4ATZ1|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MFEALSYQDALTGCYNRLYLHQVIEPSIDRQLSITSIMIDIDHFKSINDTYGHQMGDMVI
KELADEIQKRLPTSSNCFRYGGEEFLVMVQGETEASIESLVNSLLESPSRLRLEVTISIG
VKHAPQALGSVEQLIDDADQALYISKKSGRNKITWSD
>A0A174P4D6|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MSLVLSWKGYYTMFVAVCYYIYNHHMFAYIDYLTGKKLPKWKRSVVTFIINYEVFMLISQ
LRFYLIINWTIFAVFLVLEIALLYRVPWTMSLFCGIQGAMIGLAFNFITRSGTALLVNQS
LAAFDSRISSSIASLKPYPIAAGFVLAGLGFWGLQHKFHDWAEKEENPDKPVNLIFSLCL
VLSLFIYLDLNLLIYFTPSNEPIIKLWGMKSGICVLIGYYIGISHIHTLTELQHFERQSY
SVRKELISHKILEQKLEQLAFHDVLTGCQSREVARKAMLYHYENGIPFYICFADLNNLKP
VNDNLGHDAGDRYLAAVAHALEEAAGADDIVSRYGGDEFLLMTAEDGIERVRAGIKNAQW
ALKELSNSSEYPFELWVSYGIAYSGECRDMEELMRLADDRMYENKRRDKQERSGGKAAGG
G
>A0A6N2ZHV9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKKAITFRLCVVIITAMVMMALLGYYLLTKSAKEAMRTNSEIRFNQVSEVLKRNDTEIAE
LRENLKEDYFIRAKAAAYIVQNQPDVVGDLEEMRKIASLLQVDELHLFDMEGRLYAGSEP
KYYDYTFRSGEQMQFFLPMLDDDSLQLCQDVTPNTAEGKMMQYVAVWREDHGGIVQIGME
PARLMAAMEKNELSYVFSMMTTERGVTIFAADQDTRAIIGATGEIPVGTPLTSLGLCLPE
DIGEGTLYSREMVLDGQKNYCMMEMTDGILVGVSAAYEKLYENVPGNMMLIIFSLCVLSF
VTVFLILKMLDTFILNDIYGTIDGTQKIAAGNLDYRLEIDHTPEFKELSANINRMVGSLL
EATGKLSLVFQNVDIPIAVYEYNQDMKRVLATKKLGEILMIPEEELSAVLADRALFVEKI
REIRSEPLKEEKEICCLNGEERRYVRIKTYEGEGKTLGIVIDVTEAIVEKQQIEQERDID
LLTGLLTRRAFFRTADQLFADPDRLKTAMLLMMDLDNLKHVNDSWGHEYGDKLLKTAANL
FAGLKAPEKLAARLSGDEFVLLIYGAEEKEELYACMERLEQSIREARITLPAGEEAEVSV
SGGYLIYPEVCADCTEMLHLADQAMYRVKKRGKGRFEKYGGPEAKEG
>A0A2S7IW78|diguanylate cyclase|EC 2.7.7.65|Brucella oryzae|TrEMBL
MDYSTSELDTTWGSKTGLGTTQTEWVELVRSLPEDHSISLRNLITRHREQFVGVFYDRLM
SNRDAAVFLSQKIVQERLHNSLSDWLLKMFQRTADDVDAFIREQRKVGEVHARIDVPIHV
VMQGARLLKNEIIRQLGLEIASREVLARLIVHVSNAIDIAIEIMSQAFVKDARESAQTDE
AYRAFTLSHDFPLERESQRAALMEWSQSLLFNLYGNSDSPLHSLASSDFGLWLQHKADLM
FSNSGTLENIRRNVEHIDDVLLPAINSARKDNPTELAASLGLFQTKIGEVKFLLSELFQA
AAAMETGRDPLTRTLNRRFMPSILTREVRMASQKAMDLSILMIDIDHFKNINDTYGHSSG
DAVLQQVAEAILSLCRPSDFVFRYGGEEFLVALVEADENKAFAIGEELRRQIAKQPLNLP
DGARQSVTLSIGVAAFNGHPDYSHLVNAADRALYRAKQTGRNRCEKEAPLANH
>A0A649YXA5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MNKLSVKIFIILLPLAVSLLIFSYAYYKAREKLTIDHIFQSIQLSSSLGANEISHYVEGR
FTEFDRLSSEITTCKEGESSLSISSADALSFTSGFSALAISDLSGQVTAFSLSSNKSNRY
VLRKNIKGLILLPEHVLALLHTSYQEWQTTYPENLRLEQETLRQLLELNQRGEVNSQASR
DLSNLLVKIREGRRLPRQVISLASAETISKLGLIFETETYLYSRPLIGCDKQIVGFYTAV
LDRTIVEDHLYQIKNTLIQSNLQHVDVLMVRNQGLHSLSAANHLSLHELSKAGLNETNKP
QMRDDLNGMLINQPIELNIQNHLISVDNTHPSIPDNQKGINLVVYVSMEELKSSNLLLMR
EVFLYLCIALFLFASLTLYLSHYIASPIVDLRRRISVLSKTGRAKTDFSVRDDEIGQLFS
AFSDMAYSIKTKESQLVKLVREDPLTGILNRRALVNHAEDIRRLNAVSCICMMDLDHFKQ
INDNYGHAIGDSVLKTFCTLVASEIRDTDIFGRLGGEEFALILPETQLEDAASLAERIRS
RVEVQLVASLRSVVCSKVTVSIGVVEWLDDDFAKALSSADKQLYMAKESGRNQIKVQESK
SPL
>A0A3P5XK06|diguanylate cyclase|EC 2.7.7.65|Rhodobacteraceae bacterium THAF1|TrEMBL
MDAILTRRTLDALMPMHLLLNSEGRIEGVGRALQRLAPDRKLIGSNLRDVAVLDRPAGMA
SIADLNGRRVALHLRNQGKTYLRGHGVAIDGGRLLLNLALALGELQKVGDSGLTAMDFAP
TDPTLDMLYLIEANHLATTQTHRLIGRLQSAKTTAETQATTDPLTGLVNRRGFDSVLTRA
IADKKPFALAHVDLDHFKAVNDRLGHPAGDAVLVAVARRLRDIVRTSDTVARVGGDEFTI
ILHRLTDRDTLSDIARRIVAELEQPVEFEGNTCRVSASIGIAISRGGDVKDPDTLIADAD
TALYASKAGGRARHTFTAPRSIS
>A0A6N8HPJ8|diguanylate cyclase|EC 2.7.7.65|Lentibacillus sp. JNUCC-1|TrEMBL
MPTSEQHLTPERRKAFEESLNVNQIREVKGKDLTTFRYVPYASEFDKGTTQQKAIEIIYN
HDELNQTLLHFKRVFLIQLLSVVVVSILLSYLIVKWVSTPMHLAFHDELTGLRNRAAFAD
YNRKGNVSKNEMTAFIMMDLDNFKQVNDYLGHDEGDRMLREVARIINENLTAKDQAFRFG
GDEFLIVVIDTNRSGAHEVADKIAHDVQRLIAENQAWANLHISASLGLSFAPDDGTNVEQ
LCKKADIAMYQSKYATKHQV
>A0A6M8MXH7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MALDPITLLTMTIALAAAAALYLAVEWRTVRGPSLLFWSTGFAIISVGSTLALLRSSGIL
LIGIWFANGLLVTAHWLFLLGVARFTETRLSRAWYLVFVLWIGLLLLPDQPWWSKVMLAA
NSLLISLLMVKASGLLRPHGKSLSVGAVQLRYVLLAHGVFYFSKAVTAVMPGTLIDLAAF
RGAIIQISLVEGTMAVMLIALSMTGSERHRREKRIARLAARDPLTALYNRRALEMRGQRL
LDSVSAARPGALLLMDVDNFKLVNDLYGHSAGDRLLVALSEIIRSALPKGALVARLGGDE
FVMLLSDTSSEQILALGRTLREAFHSIASESFSTPQPVTLSIGANLFSQPPPSLAALLER
SDAALYESKRGGRNRIQLVDQSLEGVNALHLP
>A0A829CP83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MP021552.8|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7X3HG03|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. SW-Y-13|TrEMBL
MTSETVAPPSTQPPLPGIVSWRPLLLAAGGYFVLALVGLWLARVPGHAAAVWMANAFGLG
LLLHRSRQEAPWLMGAMFLGNIAADLLGGHPIGSALLLSGANLIELVATAAVLRSLVGHP
VLARSGQLAMFALTLSVASTVGPALSGLMGAWIISSTFGTPFLKVWWNWWNAGAIGTVLL
LPLMVSISRERVRATFERTRLARLGGMLALCVAIGAGAIRAGHDPFVVMSLPLVIVALAS
NPFATALLTLLSAIAAEGFSLAAGVDVLASRSVPLSGALILVFPVCIAFMTEQNRKGRHE
LRSSEQRFRQALEHSAIGMAIVGLDGRWQMVNRAMVELLGYTPDELRDLPFQLMTHPDDL
AADLRQIEGLLSGEIDSYRLEKRYRHKDGHYLWTLLAVSLVRDDEGRPDHFISQVEDIHT
RKLAQQQLEELARRTQLAVEAGGVGIWEWDFSQASITWDARMHGLHGTHPELGPPTLAQW
IAMVHPEDVSRVSAEMRQAIRGERRFDTEYRIVRPTGEIRHVRAMANTSRREDDTTNALV
GTNWDITEQRNLTRALFEEKERLHITLRSIGDAVICTDPVMRVTFMNPIAEQLTGWSMDA
AMGQSLDLVFRIVDEDTDLTIPSPVEQCLETLRPAYLQEGAVLQSLTGERHDVQDSAAPV
LANDGGVLGAVLVFQDITTSRALQRELAHSASHDALTGLPNRAWFEKRLRESCEQARLHG
HRAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYVIRHQVRPDDLLARLGGDEFALLLKD
CSIEHAEQVCQKVIDAVRERRFPWNGRVYDVGASIGIAAIDNDIPSVSELMSRADVACYA
AKAAGRNRVSLYRRDESDARRHHRELEVAAGIHSALDSNRFRLYAQEIRSLRPGQDDAQH
VEILVRMVDEQGTLIMPGAFIPAAERYDLMGHIDRWVIRNVLQQYGERLVRVPGLSVSIN
LSANSLGEPFLLPFLHAALEDSALPANRIRLEITETALINNMTAASRVVADMRSAGCTVA
LDDFGAGLSSFAYLKQFPVDYLKIDGSFIRNLTRNAVDREIVSSINDIGHRLGVRTVAEW
VEDESTLHTLRAIGVDYAQGYAIGKPMPLEAFLDSCEAAA
>A0A5P9H709|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MPLTLTRSDNVPRLIRAAPIGICITNEAGILEMVNPAFCEFYGYAEEELLGRSFALVVPE
AEREAMLRRHRCFMQGDEEHDERQEWEVVGRDGETHSIIAESSRLKDDAGRLKRVIFITD
ITERKALERRLDFLARHDELTGLLNRRAGMARLGEEIARARRQGSPLCVAIIDLDNFKQI
NDRHGHATGDEVLCDVAARLGGELRDYDVLARLGGEEFLVILPGATQEQAHESLERLRTR
IASASPGRSDLSVTLSAGIAALRADEACHVLLERADRALYRAKQDGRNRTQAG
>A0A5E1AT70|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MSDIILARVSETLTTEQSLESLVRQLLEMLELVTEMESTYLTKVDINARLQHILYARNSK
QMQIPEGLSVPWGDTLCKRALDSDTIFSNEVPERWADCDAAKALGITTYMSVPVHLADGS
LYGTLCATSTEKKLLSERGEHVLKLFAGLIAQYIQKESLLSQLREANAALIAYSFTDVLT
GLPNRRAIFEDLNTLFSLGRHLKRNVIIAFIDLDDFKRINDQYGHEAGDQFLIEVGKRLS
DEKTEDEIIGRLGGDEFLVACLSKAENQADEGQINLLRARLLDRIAGQYGLGSVSIVYPG
ASLGVVEVDPAGMDPDSALRVADVAMYQDKKGKGKTRFHVLD
>A0A2C9D7X7|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MLDLKTVFIFSAAINLFIVAVATVAWLRSENKLDFWYWCLASWLMVGGSLMMSMDKYLPY
VICGYVGGMIYISSTGFLLLGFKEFFHQPYRLSEAFTVAILVGLGIVVMDQFTAGTTKSV
SLLYVGPGLNLLLMARAVWRGGDGENLPSRHVAAVILLIYAVSDLFIAPIAFFDPIRFVD
GIPVSEWLKTSSIPLVLLQMATYLMAVVLKLERATEGQRLLAEKDALTGVLNRRAFYSRV
EAAAGRDGTLAVIDLDHFKTINDSHGHQGGDEVLRGFCQLVREHLPADAIFGRLGGEEFG
LCLPDCDEQDAQAVLDRLRRRVEDHAFRSHNGAPLSVTISCGHSVLLPDQRSVNETLSQA
DHALYGAKNAGRNRVHAFHAGHAPTPRAERAGVPLPGQRLGPCPATPSA
>A0A128FB76|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MPSIRQLAALSLTSVLFLFSPFSYAEAKKLIITGSSTWQPFSFINRFGEPDGIMVDFWRL
YGEANNVDISFELKPWSESLAFTRNTPNVVHGGLGYTGDRAKSLAFSRELPLNHYNVNLF
VQKDLPFDDLHALDSALVGTVKESTKHAFLVSRIPEQNIRLFPTFGSLNDAAYRGEVDVF
IDDLSTALYDMRHTGNSGQFTSRQKLYSFPLHFAVNKDSKETIADVERGLDNIRPDDIKA
IYEKWLPQNKLHLALPWLNKTAQYLIFICSLVLLTVGLFLYHRLLKHRTAELKSAVKALK
DSKQKLETATQNDPLTGTKTRHQFFTALSDKRFSPSPYVVAVLDIDHLKEVNESYGQDVG
DMAIKHLATQLRLQLPSQTLCARLGGGEFAVLFDLSDTSQAQRKLQQLQKTLQLSLLYID
QQVVPVKFSSGIAGYPYDGESGEMLVRIASTRMRANKPSQNNFTADNNDDDLFTEHRWA
>A0A5B8QYB6|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MSLEESLEQLKRQYLHALPDKKKQIITLWISLRKNWQGHMLSAVYREVHNLKGSCETFGL
TETKDIVDKLELQLKNLLDTPAPTLNVIKGLDTLFHQLLQNNLQYQPAAPVVEANMQQSP
YKPSKARHEYCIAIIEDDSNVGAMITKQLHEFGFNVQHFLNFTDFLKVQYSTPFDLILLD
LILPDYTEEALFEAATEFEKHNTRVFVLSSRGDFDMRLLAIRANISEYFVKPAETTLLVR
KIHQWLKMSEKPPLKVLLVDDQQSMVDYFSSLLRSHGLMVRGMTKPEQVLPTLEQFEPDL
FIFDLYMPEVNGLELAKMIRQLDKYTSSPILVLSSDDTMQNKVSIIQAGSDDLISKQTAP
SLFVTQVISRAQRGHDIRSSASRDSLTGLLNHTQILVAARRSVNLAKRVNQSVCIAMLDL
DHFKQVNDTYGHSGGDKVLLAFAHLLQQSLRPTDFMGRYGGEEFMLVLPDMPAPLAIAKL
NAIRESFSHIVFVEEGAEFKVTLSGGLAFSTECEEFQDCLLLADKNLYEAKRTGRNRLVT
TLIKNSEST
>A0A1J1LJ31|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MQQEEASILNQDFVALEEEFINTPGRIQPHGLLLTLQEPDLKILQVSRNALRLFGVSVSA
FLNRPLSHFLNKLQFFQIQDCLISNNFQYYNPIHLIFHIKNKRIICDGILHRYQDIVILE
LELNQDENVTFINFYHLVRSSVCKIQSATNFKDLSLFLAQEIRKISEFDRVMVYQFDQEK
NGVVIAEDKRQDLESFLGLHYPHLDIPEFARDLYQRNWLRLLVDINHQPVDIVPPIHPLT
QKPLDLSFSVLRSVSPCHLEYLRNMGVQATLCISLIKKESLWGLIACHHYSPRYVSYTIR
KACEFLGQVMAVELPYKEISEDYLYYREKLKLVRKNLLNAPALETSFIQSLAQDQINLLN
LVKAQGAMIRFGEDVMLVGKTPPLAEVQKLIEWLSQYCHQEIFYTDCLPKLYPQAESYKD
LISGIMAISLSPNQSEYHLIWFRPEVIQTVNWAGNPQDSIEIEQQGLRRLTPRQSFELWK
ETVKLKSLPWKPVEIETAQELRNSLMLAALESSEHQLRQSKELAQVTLQSIGDAVITTNS
QGQIESLNPVAEELTGWSVLEAKGLPLNDVFKILDGKTHLFSENPVEKVLKEGCIFDFSD
NVILRGKDGKERSIDNSAAPIRSRDGTIIGAVLVFRDVTQERELANRLSWQACHDSLTGL
INRSEFEKQVTKTLKLVRESPHHHAICYLDLDQFKIVNDTCGHLAGDELLRQLSCLLQNQ
VTERDTLARLGGDEFGLLLNYYSLDEAQKKAVDLCNVVRDFRFAWDEKVFSIGVSIGLVQ
ITDKTHDLATVLSAADAACYAAKNQGRNRVHLYHADDQELIQQRREIRWAARIPQALEEN
RFCLYYQPIMDINPATKPHKHGEVLLRLRDTSGQLISPMAFIPAAERYDLMKSIDRWVIR
TVFQHLEQHYLSIHLSENLAEIQEFYAINLSGASLNNDEFIEFLYDQFAQYKVPPQVVCF
EITETLAIANLKKAVQLIQSFKRLGCSFALDDFGSGMSSFSYLKTLPIDYLKIDGGFVKD
ILTDPVAREIVEAIHRIGHVMKIKTIAEFVENDAILTELKKIGIDYVQGFGIGKPQPFIL
PVIKSGGETNPNKH
>A0A2T8X9H5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Gaminara|TrEMBL
MPHETLLDNQGWFKKLARRFGSGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5B8R3F8|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MGYRFWIIFLCICSPLSVSANRLAASNLKADDSLNSTQLVRYCVDPNWLPYEAIREGKHV
GISSDYIRYLESHSSLKFSLVPTSSWTETLSFLQSGRCDLTPLLNKTVSREQFLHFSHVY
FRSPNVLVSLKDQPFLQGFENIGSRTLAVPKGYRLAEYIQHYYPSVRTITVASEPAGLEA
VLDKRVDLFVGSMFSVNAYIQQTGFNHLKIAGWGGPEDELRMGVGLGHEGLLPIINQVLD
NVDELERIRIYQKWNNIAIIDETNYLLIYQVIAATLLVIFLLAIRTYTISRYNRRLTDKN
QQLEVLRLQLEQSNAELEFLSTHDPLTKLYNRHYFNRQFVHDNRLTLSPESSICLVMIDI
DFFKEINDTLGHSIGDSILKELSEVLQHCVRESDVVARWGGEEFVILCHQTSVDAVKSLC
QRIAFAIKEYQFSGDVQLTCSFGIAKLAVNEPMQSCFERADKALYQAKALGRNQVCVDET
HL
>A0A350DIL8|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVARILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVC
>A0A2H6IR80|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MSEINEYKKLVAIESIKTNFKLINLVIVLIVFTLFLTITKFMYPILNYIPMYSIGIMLAI
TAILVSMGFYLSSLSSKNAIKQLNDYSTQVGEMVHSMEYEINQRKLMEKDLRAMSLTDDL
TGLNNRRGFLTLATQYLKMIDRHKGNTFLFYADVDHFKQINDTYGHNEGDKVLVDIANIL
KRSYRDSDIIARIGGDEFVVLPVGLHKFDPEIINKRLDENFNELNASNNKNYNVSISIGI
AFYDPEKPCFIEELLDRADKLMYQDKKAKENTGQNDLIQ
>A0A841I207|diguanylate cyclase|EC 2.7.7.65|Deinobacterium chartae|TrEMBL
MEFYPLIFNFCLLVTLTYAACLLYNAFPNLEQRRARLAHIGGAALASVLLMLSPIQLAPG
IIADLRTVPLAATALILGPRAALLAALPVLTYRLILGGNGVIVAVLSIASVIVMAALLRH
ARRRRGQLPWWSVAIIFSVHNLGLLLVPHGPELLLRSYLPINLTNALSLVVVLHMLYTFQ
RMRELTQMYREQAATDALTGLGNRRQLQHDQPHFKAHDHLLALDIDHFKRINDTFGHGVG
DEVLSTLAHLMRASLHPADRAYRVGGEEFLVLLRNTNAAQAEKVAERLRRAVEAHTFINI
PFPVTVSLGLLQDVHRFEASRQLELVDQALYAAKRSGRNRLVIAEPPALS
>A0A7W5YVW6|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK591|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRSDTAHTMGIDDLARAGEGRADETAQVLLVDGRANSQERLVKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
DMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAATVAERLRAAIESAPFMLKHAGQALNVTASFGI
ASRIAAVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A8F9MML8|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A380B2X7|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MINIEQMALVLDALPDPTFVLSKSGKYIAVFGGKDGRYYHDGSGLIGLYLADVLKTDKLN
YFLTTIEMALSSHKLLIEEYELSSKDVKGLPDTGPEHPIWFEGRIQALDFLVDNEPVVLW
VASNISQRHELEIQLRQFSDTDQLTGLFNRRRLDQDLTEQFEISQHNHTSASILVLDLDH
LKAINDNLGHHIGDKVIMTVADTCRKQLTAIDNAYRFGGDEFVIALPGQQLEQALAFAEH
LCQCLYIELQKHIVDGVFATMSIGVASIHPRDKSYEETLKRADAALYQAKRSGKNRVIAK
HI
>A0A377NAZ3|diguanylate cyclase|EC 2.7.7.65|Ewingella americana|TrEMBL
MTDNLLERISTALEAEYTLEGLVRQLLEMLELVTNMESTYLTRIDEDGAQQHILFSRNGS
NMHIPEGLSVPWGDTLCKRALDEGRRYTCDVAGVWGDSEAAKALGITTYVSTPVTLADGS
LYGTLCAASSEHRELSERSEQVLQLFANLIAQQIQSEQLLKKLQLANDALTTASYTDELT
GLPNRRSLFNQLPTLFSQAHANSRYVLIAFADLDDFKEINDVHGHEVGDDFLVAVGQKLK
EGVRADEVIARVGGDEFIVAGAGPAEFSEAQQAALAFKTRLSELLTGEYQLQSCLIDYAG
PSIGAVAINPTDTTPDMALREADAQMYEEKNRRRRWRVA
>D8NAZ6|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum CMR15|TrEMBL
MGLGGLILLLALGSVLLTMANAMYSSYRTQRDLLIRNALEANRVYAAKLAESTDSAIGVT
RQELAYGAGLLAAHMEDPARLTEEAERLRQQMGSLNSVVIVRRDGTVIGSSPASLQLKSM
RSDWGRRLLDSRIPEISRPFRAPTGRLLIFLSHPVIDDQGRLLGYVGGTIYLNEKNLLHT
IFVQHYYRDGSYIYVVDRDGTVIYHPNSGYVGDMSGANPAVAEVMLGHAGAQRIRSLHGI
DMLAGYAPVASTGWGIVVQTPTETTLRDLNGLMLVTLSHSVPLFVLSIVFIWWFARSISR
PLVELASQARLVATPERLERIKTVSSWYIEAHRLKRALLRGTRLTSTRMARLNLEALTDP
LTGLYNRRGVANALRLHAGRHQPFSAVTLDVDHFKRINDRYGHDVGDQVLRHLAALIREQ
ARHGDITGRIGGEEFILLLPDATPDGAFKTAERLRLAVEARPNPTGQVVTVSLGVAHYPQ
SAGEVDAVLKLSDLALYQAKRDGRNRIVVYRAERADGSADLEPASRIRAEEGN
>A0A379ZCZ1|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MKLRDNFKRKTIDRLDYRYHLLLLIVPICLFVLLFIFNAPTENWTILPLLFVCIIYIFAY
SLTYYLHQGRLTRLWQHLEQVVTMNDAIYELAHLSSHYKNEHAFLDALLNKAVYVINGAE
MGSIIKVNENNNKLHFEAGVGLDLTKLRLLDFTLEQTFEYRLTKGRCDQVVVVNNIENIN
AGSTLSKEEQHVLLTASKQPIRSTLSSPIRIDGRLYGMLNLDSSSVGAFSDYDRNLVSIL
THEASNAIALYQKSQQITKLANFDSLTGLYNRKNFEDELQHWQQKPHLGSFLLIIDMDNL
KAINDAYGHQMGDIAIIQIANAILKCWQNNAIISRFGGDEFVVLCHGPQTQIEQDLENMR
KNLNHDSELNLSFSYGIATFENDWSQSFKIADHAMYEQKRAKKKAIKALEAFAIKAQHTN
>A0A7Z7NNL5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MTRLLPTLHRLSGHAWQLLASRPHRFVVASFSLSVMLLVLLLWRGLQLSQDREIETLRHM
QAVRAQSMDALLQREAERLLSVRNFTEHLLQIQASTPGRPDAALRATLARRDEPVWPVPA
HDAAAVYGVGAAALSGLEGFERNEARLAADVVVARSLSHLLSAAPQESGIRRRIAYVSRN
GVLTAYPSIPPQQVAPAVHRLAAAPYFQDSLPARNPGRQVQWRIAPATSERDQVSLFLSV
PVYAGSDLRGVAILELPQRSLDDQLSAAPFHDASSYLVDREGRLIGASARNVRAGETMQA
ALSGPWPAATLEAVFHADAGLLTSVSGGGNDLMFRRLRNGGLAMVDEIPVNQLWLAGAAR
LSGVIGAGAAALGILLCATLAVVHSLFRHYLARGEALRTLAETDALTGLANRRVFAARFA
AEAARCAAEQRPIAVVMLDIDHFKAINDRWGHASGDVVLRAVAAALRSGVRKDDLPARLG
GEEFAVLLPGTGVDDAAAVAGNLRQRLERLRCDPAADALCSEPMRFTASFGVAGSAPGVP
GSLDALLMAADRRLYAAKANGRNQVVAHESGNVASHHRNLKGL
>A0A735IHE5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSNQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8K1IPT6|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MTSSPNSSSLTGEILVVDDTPANLTLLRQMLSARGYNVQVCRTGEVAIKSATLMQPDLVL
LDIRMPDLDGYDVCRWLKTHPETAEIPVIFISVLETTEEKVAAFQVGGADYVTKPFQAEE
VIARVEHQLLVRRQKAQLELEIRERELTEASLTKSRSLLASVLNSTLDSVSALQALRNQD
GTIVDFEWLLANAVAATAAETTPEAITGQRLLKLMPEYAAVGLFDDLVRVVETGKILNRE
LCYESDTLCGWFQAIAIKLDDGVTLTFRDVTARKQMELALKASNVELQQQANLDGLTQVA
NRRRFDEYLQETWTYCLKHQRPLSLILGDVDRFKMFNDTYGHQTGDVCLQKVAQTLRSLV
QYPDDLVARYGGEEFAIILPQTEAAGAIRVARRLQDAIRQIILYPEGDSEPTSVTISLGV
SSVTPFSSLPPAALIEAADRALYRAKSEGRDRACWQLVRSLT
>A0A2X4X3L5|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MIACLVLSTLCALVLSRRMLLGIVSSLDDIAKVAHVVRRDRTFGLRVPSAPIAELHELSN
DFNGLLDELEAWQAHLKQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIQPTEKLAV
LFIDGDRFKEVNDSYGHAAGDAVLTTIAGRIRAQLRESDLVARLGGDEFAVLLAPVHSTE
DVLQIADNIIDCMTQPIILPNDEAVTTSLSIGIALYPEHAVTPQGLLHEADDAMYQAKHR
YNGGWRLAIQK
>A0A517XXQ2|diguanylate cyclase|EC 2.7.7.65|Urbifossiella limnaea|TrEMBL
MELTRLAFTVQALAAPPVALLVVLLARAVPRPFLRHWAVGWVALAAALLSLRAAFLLPRG
LLPAGLVTSVYYCLEYLFGYLVWVGCRELVGRPGPRWPDAWVLGPAMAFGLVAPWVADHV
SDVFPFHAPMFGSFFLLALAATRGYTPTGPRTRFGIHVVRLCLLLLGGLFVHYGPVSYHT
LRLGGAPPEYMLLSPMYDTLAEVGLAFGMALVAVEQVRDELDAANHRLADMNLRLEESNN
RLEAASDQLEVAARTDALTGLLNRRALDALLAARQGTSFAGAVAVVDLNSLKHLNDTYGH
EAGDAAIKLVARALRAHFRISDPVFRTGGDEYLALAEGGRAADLADRLAAVDAAIRGVRL
PGLPAPVDLVVAWGLADFGSPAEFPAAQARADQAMYAEKARRKAAARA
>A0A7W8UMZ0|diguanylate cyclase|EC 2.7.7.65|Rhizobium lentis|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGHEALAICERNQVDLILLDIMMPGID
GFEVCERLKASKKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGMGDLMRTGEGRADEAGQVLLVDGRANSQERIVRALKPVAD
VLALSDPQAALFEAAENVFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLSVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVAMPDTSPEVAAAVAERLRAAVESAPFMLKHSGEALKVTASFGI
ASRMGSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A8F0CFF4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6P2E3U2|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. PBL-E5|TrEMBL
MRARPAGEEFCVLLPDQGEALVRTLADRLRILLAAVPRPDGRLTVSAGVAGMRVDESVLQ
TLHRADLAMLKAKQSGRDAVCVADEIH
>A0A1V5HTL6|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.BinA120|TrEMBL
MKSGFTKSRQLLLVAVVLLVLILSNGAFLWREVSRLQNDALIINYAGIMRGSIQRACNHE
LAGRRAGAAFEQIDEIMSNFEERKPGFEIKMFEERFFKELQELKASWGLLKEQIARFRLS
PDAINRERVLATCEQCWVASNRLVFATQYASEAKLDVLEYVFILIVLNVIAVLIIIDLIR
NYVRQQLEFAAHHDQLTGALNRYSYSIALDHEIKRSRRYGSPLALLLFDIDNFKAVNDTH
GHKAGDSVIEEIAYIVKGQIRDSDSLSRVGGEEFAVIAAESDRGRAAAMAEKLRGLIQEH
RFRPAGRVTVSFGVAALRPDDTADTLFRRADAALYRAKEGGRNRVECA
>A0A1V5HRX6|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.BinA120|TrEMBL
MGDIDHFKAINDTHGHHAGDLVLISISRAIIDAMRDRIDWVCRYGGKEFIVVLPETRIED
GSVVAERLRAKIENTPVEASGTSIPVTMSFGMTGFIPPVRGMKITMKYLIESADSMLYRA
KNEGRNRVVGGPVENTPER
>A0A833Q630|diguanylate cyclase|EC 2.7.7.65|Burkholderia gladioli|TrEMBL
MPNRASPTRLNNWKSGLHRDANFFRYDTRFARRHPNQPRDLALRPVPSGIALFRYAAMSI
PTALIGIASLSCLMSVAVLGSLFHAQIPGIRHWCLASGVLAAVTALLLLFQRSPSIILGA
SALLVVASLSALQGFRRFFHLRASLSGEYLAVGAILAGLVYWTYLSPDIDARVVIISAFL
GYVRFVIAWLVQRHRPAGRPRYGYYFVSGVALLGAFVHVIRCAVYGLGLAHETDFLEATP
VNVAFLGMATLTLPCLSVGMVMLAHDRLAQRMERLATIDDLTGVFGRRAFIARAEALLGS
ARGAKSPLSIALLDIDNFKSINDRHGHAAGDQALANVAATISREIRQADVLGRVGGEEFA
LLLPRTGKEDALRLVDRLRAIVASAVSEGPAACVACTLSAGVDEFRACDTLASAMARADA
ALYAAKAKGRNCVVPAGAEQGKWIEPVETAVLNRR
>A0A7T8LLQ6|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQSQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDATEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWVLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A1V6HRZ1|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MDPETPTDRRAGARPASDPLAGFPHAEPGGELAFRDPLTGLLNRRALNLLFAERWRPLLA
AHGEITLLLFDLDLFKQINDAYGHLAGDQVLRRVAELMRETFRAEDLLVRYGGDEFVAVL
PGAGAEAAPPLVTRLREALAAESLPEPLRARARQLPLGSSVGIASAPADGLGGEEVLAIA
DRRLYAEKRQRRRPRRRRAWLLAALLATVGAAAWVTAQREVRPLAIPVAPAPVATLEPAR
AAEIAALQAQVARLTEELAAARLAHPANQEPSAREGELERTIAALQEELERLSEPPAPAP
VPPPSPPVRATPAAAPPPAPAPVPVVRPAPAPRAEAPRVTAPVLLSVPRPEYPPLARRLR
RSANVELLVEIDADGRVTAVRQEGPPVGLGFDERARQAALRARYQPATRDGEPVPGMARL
TVSFHLGEGEGP
>A0A509C8D6|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 6947|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKHRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKDTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGSLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A8G0SSU5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MPSRSALFSQRSLILALLILLACGFLATSLLGYFSSRGAIRDGIVNTELPLTSDTVYSEI
QKDLIRPVLISSMIAQDTFLRDWVLAGEQEPERITRYLDEILSQQNTCTAFFVSERSRTY
YQAKGVLKQVKPDAWRDAWYYRVRESQAPYEINVDLDMANHDRLTVFINYRVLDYDQRFI
GAAGVGLSVESVVKLIDAYQQRYQRAVLFTDANGKVILTGSDGSMHGLRAGQQLADSKAF
ETLLARMPVPSPGSHEYQDEAGHSHFLNVRPIPELDWYLLVDKRESGALDRVRQSLYLNL
AICAMITLVVLSLLHAMVKRHQQSIESLATLDSLTGLPNRRSFDLLAGQALQQAKRENAP
LVALLIDLDHFKLLNDTHGHLAGDEVLRQFANVLQGSLRQSDILCRWGGEEFIVLLRETE
GRQAIDVAEKVRRRTEQLIFSYNDQPLRLTTSIGLSALQPDDSLHSLLTRADHALYRAKQ
GGRNRVCSEMPGAVHA
>A0A0B0HJB2|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus sp. BCO1|TrEMBL
MFRSYFHLPTVEEWVWIYFLAITAFFLTYFEIQVVENKNTFSMDSAIFLAAALHFGPSVA
IWSFLLFSLVRIIYHRHIPLWAHLLNFSMYLLMMVAAFLLFFFFGGKIGDEVSENLYPYI
FSLTVYFAINILIIAGFYLTDRSKKFNRVFNIGLLKEVFFAYFVTLLLSLVLIILIDNEG
FFGLFLFTVLVVLLSITFGKVLEWYQEMANQANKDYLTGLYNHGYFKDYLKELFRETKRT
GGQFSVAFLDLDDFKKYNDYHGHVQGDRLLKFVGEYLKNETKDRGFTVARYGGEEFAIIL
PKTEKHEAAAFMDQLRKKLNDTPFDGVERLPYRCISFSCGIAEYESDMYEESELLHKADQ
ALYYSKAQGKNNVQLYDEKRISRDALKFKEDLDAIEEQLKLLLYKDVYTYRHSKRVFTYA
MEFSDRLPLTEEEKRTLILGHSFMILVKSKFRETLLIKQANSPLMNGK
>A0A6L3B495|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTSSSDTRSPADSLGLVLDEHLRWIGQWHRAVFFRGGEGGERVSAPASFAAWCVAVNADD
LAHQPAVEKLVTLHEQMHRKAKLLLLKAAGGESPSEADYEGVIARFEEFVLHLRRVERAF
GAAASGLDPLTGLRTRRGMQEALEREHNRFRRNGPAFCVAICDIDRFKGINDTFGHDIGD
RVLAATAAAISRGIRSFDEAFRMGGEEFLICLKETGLAEGFRVIERLRGELARTPVVLPD
GRRIAVTASFGLVEAGEDLPVEEMVVCADRALYQAKNSGRNRVVRYGVDQPEGVAGRSAL
PNRR
>A0A454A544|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6:K15:H31 (strain 536 / UPEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2X3IY43|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MNKDLTTPSRPTFKGTLRRISIISVVIAMLAVWLLLSVASMLTLKQYAQKNLELLAVTVS
HSLEAAVVFRDGTAANETLAVLGKQGQFTAAKVVDVNGQEITHWQADKPSQHDMVGGLVT
RWLYPQPNQATHLA
>A0A174CH74|diguanylate cyclase|EC 2.7.7.65|Mitsuokella jalaludinii|TrEMBL
MTNLPKGISCAFVFGDVNGLKRMNDVHGHEAGDVLIKTVARIMQRAQQGAGEGHVFRMGG
DEFLMIVEHADGQKTAAIIQSLRDAFRANNVSVALGHLTCMTPISDIDAIITKVDREMYK
DKGRQKR
>A0A517R939|diguanylate cyclase|EC 2.7.7.65|Gimesia alba|TrEMBL
MISPEKIWSSDQLPTLPAVAVRLLDLSKNPDTDIKEVIETIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITEGPLKSRFDSYWKQSIIQSAAAEL
LASKLGNELKYDSFLIGLLQDIGHLAMLRSIPNDLLPVLEQAESQQRNCSEVETEVLGIN
HTEVGVKMMERWQMSEQFKSAIAHHHDTFEQLKALESDPNFKLIIIIATSASIGDYFCSP
NSGLALHRLQELTAEFYNMPHDDLHGFLENVQSRFEEAAQVFQVNMDDIGSPYEIMATAN
EQLVQLTMKAQVDSTQACARQAVIEEQKVKLESENKQLQSKAIHDPLTKAYNRSYFNEAF
EKEIYSCARAAHPIGIIFSDIDRFKQLNDTYGHQFGDLVLQRVAHVANESTRRSDVFCRY
GGEEFVIMVNNPSENGIKEMAERLRALIENEVIEFEGKRVPVTASLGAVVGIPPRNITGF
AERLVAEADEAMYESKEKGRNQVHVRSIISQEDQELHRLIKRSRFSRWLVTKKVFDIPTI
SKALLKCPKQGEQVKIGELAIAEKLLTAEQVVKILDQQKETESRFGEVAIRQDLLTLEQI
AYLLALQIEPPIALGKTLITLELLDSTNTAELVKQYLSEIKDNAAPKEEHRTEYANS
>A0A6I0S7H5|diguanylate cyclase|EC 2.7.7.65|Bacteroides thetaiotaomicron|TrEMBL
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVS
>A0A3V4QKI8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kottbus|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0T9NNB3|diguanylate cyclase|EC 2.7.7.65|Yersinia similis|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMLSSSPKTPPVTFPVVMIAVINLSAAAY
LIFISKNYIDKKSYVDKNDYANKLNLFSIIIGVLWAWQIILKYEYLETNEDNYLLLSLFT
IFFISTIALSDNFFAFCLHTAPSAITVILLDDFHNIFRIIFTIMLPLIGFSLHHLMLRRT
DNFTRKLVDHLSNEREKFSDLSMIDPLTSLYNRRGLESKLETLLSQSPGNHYVLLLDIDH
FKAYNDNYGHTMGDQALVRVSAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAER
VRQRVLGLDIPHVFNHKVSTTVTLSAGISPLQAYDLAASLKAADEALYRAKKNGRNSIEF
AKDELSNVQSSP
>A0A1A8TJ90|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MMPQTEMTELHWLFDMLQHIDVGLVVVNTKYEVELWNGFMENHSGVSSSNARNCSLFDIF
PTINQSWLQHKLDNAFALRTPIYISWEQRASLFPFKSYRSVTSISDTMFQNVVIRPINNA
NGSVDHLCLVVYDLTDVAVNKAALSAANRKLDQMSKTDGLTELNNRASLDRAIKLTFDSF
AVGNSGPHCLVMADIDHFKNVNDTYGHPVGDIVLQEMAKILSSASRRGDFVGRYGGEEFS
VLLLNTTKEGAKVYCEKIRQQVEQRVFNSNKGDIKITVSLGCSELGKQHSSIEQWIESAD
GALYHAKHNGRNQTVIAD
>A0A735HGY6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 47:b:1,5|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLSVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0Q0JNJ3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MLEENKWTFRRADKQFSLEKWQKTIDLMTELFSAPAGFIVHKTDDVYRIIVSSEQQENPY
DAGAELSADDNIFCKKVLRDMAPLYVDHASQDSQWDDSPLVKDGFESYLGVPISWPSGEP
FGTFCVMDFKQTHYQQSFLELIEQLRDMVEDDLALLDNFTQMREIAMLDSLTNIYNRRAI
DLLCQHKLNISKRLGFDISCLFIDINSFKPLNDTYGHEVGDLALICLADTMKECLRETDI
IGRLGGDEFIALLQVQPGDCIDSIADKLNTTYQSNLEKRGIPVTSLSIGSGVIAQPKENF
AELLKRADEDMYEKKQASKAAR
>A0A0Q0IU89|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MERPSVPLNEQARLEELRSLDVLDSQSEPAFDRITRLAQQFFSVPICVISLIDEHRQWFK
SCVGLDVTETARDVSLCAHAILYKDPLVVENALNDKRFADNPLVMGDPNIRFYAGCPITL
KSGNRIGTLCLIDHQPRSFNKQEIKALQDFAAIVEREFAIMQLATTDELTLLPNRRGFIS
TAEHYLDLCIRQHLKAKLVFIDLDNFKAINDKFGHAAGDRVLRDFAGLLENCCRKADLYA
RLSGDEFVILFTDLNTSECDTIMQRLLLSFSDLPNSFNNQVELGFSYGIADFSGQQPCSL
TKLLSAADARMYADKAQKKAR
>A0A2X2I6E3|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MTYVASIPALYSDACITYATLSVSYFALSKNSPFSYQSERWKRLLFGLMAGLAVLLLNQN
QLELIGNVHYSFAMIPMILVTFYGGAISGLACYLMLLALSGGFTVDNLFIGSIIIPLLLS
RVWLRKSNRVFYLAISLIALYRITVVWYLVDMRTLWLDVLLYQAISALCLAICYHALNFK
ERHIRAYFSMRDKATIDSLTHISNRASVDNRLMAQYAERRPCGLMILDLDNFKRINDTYG
HLAGDLLLTQVGQLLKNSVRSEDFVGRYGGEEFMVITASYDPAVIGGVAERIRHSIEARV
FSLDAGRETRITISIGASLYLPGMAIDKAIEVTDEALYDAKRRGKNQVVCSRLMQYSPLG
DGFRHL
>A0A380B040|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MYEPCFPENETERLSVLHSLNVLDTNSVEKLDRVTRLAAKYFGVSIALISLIDRERQWFL
SRSGLEARESPRNISFCGHAILQRDALVVPDTAADPRFFDNPLVTGGPKIGFYAGQPLLS
LDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHSIERDIYTEALKSNLQRSEAL
FEQTFSQAAVGMALVSLEGYWLRVNPRLCEMLQYSERALLERTFQDITYREDLHNDLGLL
HQLLANEIDTYSMEKRYIRADGSRIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEAD
LYTLQHELEDRVVTRTRELNFAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQ
IDANERYLFANSAYKSWFGLDESHLSAMTVQAFMGDEAYAAAKPMIERALKGETVSFENE
LQTRQGTVIIHNTLVPSETRGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
LGATLQACCPQQQMALLFIDLDGFKTLNDSLAMISAILS
>A0A0P9JZT0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MQQNNSHTTELWRSFIEVDGLHSAELKRRVFSFLAMSGIALVVFSGLLLANFQTYPWLLS
ITLLGALIAVFINVVIYFSTRQLKYCSIGIALTVLLLSILLVYTGGKENTALYWIMFYPV
VVFTMLGVRFGLLLTAFAIGAIAFQLYGPDFGQANYGHVEKSRFLSGFSLVVFFAFISEY
FRDKSHQAITNITYNQKQKANTDALTGLPNRRFIDAIFLTKMEKTTAEFLPMTVIMCDID
RFKAVNDNHGHDIGDKALMHIAKLMQNQLRYSDVVARYGGEEFIVCLPHASMRQAVQIAE
KLRKNIEDHPVNLESGENLALTASFGVAEVHSVVAFYNAVKQADEALYSAKRSGRNRVAT
L
>A0A0N8Q4P9|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MQKDLLNSVVKITRHRDVDSLELSLLSTISEFLQPTEAALYKDLSRFNGIGIESSASLLS
DEQGKIHWRSREIIKEPTKELQCCLESACTISLQDKSGNETRWIPVMIDDQVSGAVYIVA
KHLNSSEQVTLNALCRIYENYLTILNESERDKLTGLLNRQTFERKIKQLLEDQLHSHNTP
QLQGNRNKRYDESSWLAILDIDHFKHVNDTYGHVCGDEVLLTLAQKMQLFFRSSDLIFRF
GGEEFVVVFEPTTLEHITSKLAEFQQYVRDNKFPFVEQLTLSIGFSRMSPYDFPISVIEN
ADKALYVAKNSGRNQCVYYGDILDEDSQEHPSADDVELF
>A0A3S4FDC0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sanjuan|TrEMBL
MFLPVAAVLVTQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGM
WIALMGVNMLPAAALFMMLSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSS
LEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNE
FDHSRRHHREATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGD
EFAVIMCGTSADSAITAMSRVHERLNTLRLPGAQQVMLRISVGVAPLTPQIGHYREWLKS
ADMALYKAKNAGRNRTEVAA
>A0A6L5E9F5|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MNDENFYKKAVDLDEESFSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
SGVWWLLLVGWAFVWPHLAWQIASRAVDPLSREFANLKTDAVLAGMWIGLMGANALPSTA
LLMIMCMNLMGAGGARLFITGLALMVIACLVTLQLTGVSLALRSAPLEGGLTLPVMVIYP
LLFSWVSYQAATKLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHSRRQHRDATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRMTLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRVHEGLQGLRLACAPQVILHISVGVAPLTPQFGHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A1H6YB39|diguanylate cyclase|EC 2.7.7.65|Azotobacter beijerinckii|TrEMBL
MPSISPEHQAAEWKRLLEQFPVAVATRVRELATAHQAVLAGYFYAQMLQDEEAMLFLTHE
QVKSRLQGTLQQWIAMLFAARPDEAELLPLIAQQQRIGEIHARINIPIHLVLRGARHLRE
RLFALLCQQPVDAEHKLLGQRLIGETIDLAMEIMSRAFSDAHDRNSRSEEGYRLFSVAQN
LGVEQERQRGALLDWENQLMFDLAVGHALAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQGMQHIDGVLLPLFEQAAAQMDADRRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQNERTFAVLAIDIDHFKQINDEFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDINANSALGVAEKLRRQAGQERFRLPGEHDLQLT
VSVGVALHDGHPDYQRLLRCADRALYEAKHGGRNRVVLSGGA
>A0A437IL32|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVSNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLSVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A8H9U2X0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIVGENSHCICRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDLVLRVLASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGFRLCRLIGQKKIPY
ADGEIGITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A7D6Y2W8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQIWYDCVV
PEDREHTENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANQVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAMEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVINAINDYHFTWEGRLHRIGASAGITLIDDKNHVATEVISQADIACYAAKNSGRGRV
CVYEPQQNQMHAAPGMLSPEEQRNIITHNPMLMIAHGVASPRIPETFSFWLLSLRLWSSE
GDVIEEQAFRASLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLAWMENSPLPPRLLHLSVPGEVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A7D6Z273|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A7G9HXH2|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHMLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTGLEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDNRMTTTFSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMCMAASAAESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRIEVYQE
>A0A7W3E7L6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVQDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKILY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A381GP01|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MTGLYNRKILTPTLEQRLQQLVNAGTPVTFITIDCDKLKVINDTLGHKEGDRIITLLAKA
IQTSIRKNDYAIRLGGDEFCIILIDHPGELTPRLLERIRYNLQIIAQDIAISFSAGIYTM
QPKRHH
>A0A7H9FV45|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQSGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A6N2VCM5|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MRRLYQKLGPAVTASVVAAVVILCSLFNFNWQIRSDLRGGREDSAQSHLELVEKMGRLLT
AELVGTMSVLLAVVVTERKKEKKRLVLMKNAYHTALSKSSDLFFEVDLSADRLKIHSCRV
EGVWEQRDLPYSEIVSCSAKKCAPQFQEAFTKTFSLEYIWDAIKKSIPSVCFEYEAAVKE
EERWYSATLVPVFTGDKASARLFCMERDITELKQQQIKLKTSAMLDGSTGLYNKKTSEHM
IRQRLGKQSEGQKYALFMIDIDDFKAINDSYGHMEGDAVIAQTALQLKKLFSPADITGRF
GGDEFIVFFDEISDRKEIEEKAEKIKEMLRSAGMNVSFSVGIAVSEGRNMTFEVLYKKAD
SALYATKQRGKDGYTIYTMSEV
>A0A6N2W1T0|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MKEKTRNYSFAFLVILSLITALGTFVYGMKNYHTDNISINQRQEITSLSEGWYYIEEGKK
AEISSLPVKIKDSGRKSLTIYLDLSKPAAEDAVLCMENFHQAVEVFAGDRKLYSYGAGNK
GPAGWILGNIWNIIDLPEGVHGKTIAVKITSPNTPGRWKIPEIKYGNRSAVMQMISENCI
GIAVFAILSGVLGSGFLLVFCLLRWKGLDYNSKDFVYIGLFIVISTLWIITDSKIPQFLT
KRLTPIYILSFLLFTLMPVPYLMFLRQICRHGKGALDCLSILFLLQTIFCAVLYITGTVD
LIMSLPVTHFLIICTVAASIFLCLRELLHYHNKDTFFVLIGICILAAGAMLSLAAFLPQK
ISDNSLFFRIGLIGFYLSLCYVSLRRGMGLLRTSMEAETYRRLAYKDAMTGIGNRAAFDR
DAGILHAKRDTNTFAVAVFDVNNLKYTNDTYGHAAGDRLIKDTADSVKDAFSAIGRCYRI
GGDEFAVIMEHIPDESIEEAFCSFRENIRKYGKGNPEGLDAAGGWVKGENTGTDFIYRLF
HQADTKMYESKEKAKHAEK
>A0A2H5XEH9|diguanylate cyclase|EC 2.7.7.65|bacterium HR17|TrEMBL
MRVAQAEQWVKQLMELAVMATVQGTAADEGGIAISLGDGTFYLLATYGGANAAPFLFKLP
EPLAKVLPRTPAALMFPDTLFLPATAPFTHALLCGVSEQERLGMMLWVGRYRRLPFSDQE
RALLERFAHGTYRLLLPFVPFYHSTALLRSWLEMSLATDIPEKLEQSVTFLLELLLHVAN
SSDGAIVLRGKSGESQLGVAYGKGAHLFHPDRRAALLRDPCWVVQSVAESDWNGWIALRQ
RRLRPAHLFAVLRLGAKALQGLVNWSRYALWLDHLVWRDPLTHLLNRRAFLTRLENELHR
SVRYGYPVALLFVDLDGFKPINDLLGHAVGDKVLQQIARTLQSSVRRYDIVVRYGGDEFA
IVLPATGVEGAVVVAERLRSRVAALTVDELTAIRYHLGVSVGVTVSLPTAPLSVQQLVEL
AERAARLAKVRGRNRIEVLLPDRAQEVTPSLPSVPRDLWAALLQYLCHSINNPVSGILGL
TQIALQDLSLPPSLREVFSQIEALALRLRDFSHRLARQPVGQLLCELEAFQRRMTAPIAT
ELPVRRDDL
>A0A239SHK1|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MELLLDAVFLVNRSGTLMYVSPACEAILGYSAQELMGRSMIDFVAKEDRDRTIEESKLVM
AGRLRIGFENRYIHKDGHYVHIMWSARWSEEHGMRIGVARDVSARKRAEALQRATYSISE
AAHDAADIRSLCKAVHDTLGTLFPIDAIVVATCDADLRVWDKAYQYRDSTDIPLLDWAQA
EALSTQATNAQEPLWQLIETVPDADPATHAVQVRTESFSLNDNVEAARHALAVLPMHTAR
RAVGTLMIYGPVRALQAEAAQRLLAFVCDQTALAIERKQLIDDLYKAARFDELTGLPNRR
TFGEFASEAVRRAQRTNGKLALLFADIDGFKDVNDSLGHATGDLLLKEIGRRMKAGVSDC
GFVARHSGDEFVAVVQDAEIVERIDFAVNRLRSEIEQAISVNDASLTVRVSVGVAVFPDD
GESMSELIRVADQRMYANKAARKSGGASFLERLM
>A0A8F7LHR9|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MPYASWLPIHPQLLSATQAQKVLVIDDVEINAALIASVVGTLCDVQTATSSQKGLEMAMQ
YHPDLILLDVLMPEMDGFEVFRRLQNEPRTAHIPVIFLTGISDASAEEVGLNMGAADFIA
KPFRTAVLLARVRNHLQLAQQRNLLERLSHADGLTGIANRRYFNTMLTREFSRMQRHNQP
LALLMLDVDDFKAFNDHYGHVHGDECLQQVAHAIAQCLHRPGDMVARYGGEEFVCLLPDT
TLDGALKLAHDIQAAIAALRLPHVQAQATAFVTVSIGVASELPHQLGHSQQILSIADARL
YRAKRGGRNRIVSND
>A0A5P2H540|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pauculus|TrEMBL
MTPDSAANSRNTPNATHAPAIAPAPLPAPALPWRPLLLAGVGAFVLAASGIWLSRLPGNA
AALWLANAFGLGMLLQRPRYEARWLLAAMFAGCLLANWVGGDSVIVAVLLSCANLLEIVC
SVTLLRLMSAHMGNVRSGPLASFALTLGVAATVGPAVGALAGAAALAQAYGTPFTRVWWT
WWNASALGMVMLLPLMVSVTRARVSATFQRGLLVRLTILLVISVAIGAVAVLQSHDPFVA
MSLPLVVVALLSNPFATAVLTLISTLAAELFALASGAPDVAMQRLPLSAAAIMVFPVCIA
LMTEQNRAGRAHLRNSERRFRQAMEHSAIGMALVGLDGRWQMVNRALTDLLGYSPDEFRG
RPFQLMTHPDDLAADLRQVERLLAGEIDSYRMEKRYRHKEGHYLWALLAVSLVRDEITGE
PVHFISQVEDINSRRLAQEQMEQLSRRTQLAVEAGGVGIWEWDFTNASITWDARMHALHG
TTPELGTPTLAEWIAMLHPEDVSRVSSEMRQAIRGLQRFDTEYRIVRPTGEIRHVRAMAM
VSRQEDVRAGDRDSGMTRALVGTNWDTTEQRRLTSALFEEKERLQITLRSIGDAVICTDA
AMRVTFLNPIAEQLTGWSMDAAMGQPLEQVFRIVDELTGEVIPSPVEQCLQSLRPAYLQE
GAVLQSLTGERHDVQDSAAPVLTGNGDVLGAVLVFQDITSSRALQRELAHSATHDALTGL
PNRAWFEKKLREACESARQHGHRSALCFIDLDRFKIVNDTAGHGAGDVLLRELGYVIRHH
VRPDDLLARLGGDEFALLLKDCTVDQADHVCQKVIDAIRGRRFPWDGRVYDVGASIGIAA
IDSEVPPVGELMSRADVACYAAKAAGRNRVSVYRRDESDARRHHRELEVAAGIHSALEAN
RFRLYAQEIRALRPESDPACHIEILVRMVDENGTLIMPGAFIPAAERYDLMGHIDRWVIR
NVLHDFGPRLAAIPGLSVSINLSANSLGEPFLLPFLHAALDESVLPARRIRLEITETALI
NNMSAANRLVAEMRRAGCTVALDDFGAGLSSFSYLKQFPVDYLKIDGSFIRNLADNVVDR
EIVSSINDIGHRLGVRTVAESVEDEQTLHTLRAIGVDYAQGYVIGRPMPLESFIAGATHQ
AAETPPAP
>A0A8B6IQB2|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRAERQAVQQRQVFDTLSDEVENDAWEQS
DLARLYVVKPTPETLQQYQQLLHTDKSIEHRLAGLKDNGASREELALLHDGLQIADELQD
EQQAALAHVARGDAPAAIAVLYGKAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMHCVAQWLSPAGETTSFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDTGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTG
>A0A8B6IWL3|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MDKSLRLTLKKLHQLTRPSHVVNVCFIVVLFCSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRRLEAWRVALPNRRTL
PVFGVSGSVVSNNPMLLADDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMAHYSQAVNALWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVNEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWTKLRNFDGVLLRVHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVLRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAITVARACQR
SGRPLAVIQLDLDHFKGINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCIVM
PNTTLREAAAVAERLRLRVQGREVFLHNNVTLRVSASFGVSASEEQGEYQFEALQSVADR
RLYQAKQNGRNQVCFSGEA
>A0A2K9JTM8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MTKYHPYSKPDQVEALKFALLRRVAAYCMWLHAGLIGVFWHLEVNILAWVNVGSVLMWYV
GIKLIDASKPSIALRVFCLEVAVHATLVCAYLGMSLGFQYYLWTVSCLMLLDYQLRLRNA
VIYSVVLITLFAVLELLFGDVAYQYRYQQLIPYVHFANVLICGIPMIYTISHIRKMTVQQ
RDKLEELAAHDPLTQMFNRRYARELITHAKENCISTHSPLCLVMADIDHFKKINDTFGHD
KGDQILKSVAETIKAHIHPADIAVRWGGEEFLIVLAPCSSGEAMQRMEKLRRAVEATSFE
NEILKVTMSFGVANWDPSQTFEVVIQHADAALYDSKHSGRNRVTAAPILRVSEGVS
>A0A2K9JUA3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MSISYSPCGHELTLELLAQKSELVLMQALERVISDVCGESYAFYFSKSLSEKEVPKSIFV
SHRDFCVVVGPVDAVVDKLQQRQDDKHLIQYHGDSVIPFYHQAQLVGFLYIEGQVNLTTA
TLMKHLLTVFAHQMATLHFARIDPLSELLNRQTFDEKVMEITNGDGFTVCRDDSEDRKWY
LAMVDIDHFKQVNDNFGHVIGDEVILLVAQKIKANFRAEDYVFRYGGEEFAALFQSRNDD
SAAVALERLRSTIASSRFPQVEHVSVSLGFTEVVDTLQVSEQVHKADLALYHSKENGRNQ
VTNYLALGLAESQYACAEIELF
>A0A2K9K2B2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MNKRIFLQISGLVIFTILVSGGLFYWSTLLNHSISSFHQSWQSETEVAIKRAELLAELER
SFGYNGFIHHFKNYVLRQDEIYYEQALADVEATKATILKLQSTVLSSQETKALAVIQHTF
DEYTQMLALAKSKFTSGRLSSEVVDRLVRVDDTDAEVAFNYLRKLIGEKFELAKQNQSVK
LAQTQELSNTGVLLLLPIVLLFACLNIFTLIFVVKLINEKRKLFNSTPDAILYCDKDGRL
KEVNKACTDLFGYQPQELLGMKVEDLIPERYTGKHVADREKFQGTSTMRRVTHDGLKIVG
RHQSGVEIPVDIALSTVSVSKNDVFIAVIRDLRQEQELKNRAELDFLTQVMNRRKIEALL
KEEVQRAIRYHRALSLLVIDVDHFKQLNDTAGHQDGDNALKEVGQFLREQARPSDHIGRW
GGDEFVIICPETRPDAALNFAQRLVHEFTRFTSFGLTFSIGVAGYELIGESFNHKRCFEE
ADLALYESKKSGRDRASLYIAPRSSLDKKA
>A0A745Q8F7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWHYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATTEKLQELADRNMYQAKHRRAERSLN
>A0A157SSI7|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MNSPTATYVLRWKATCAQYSSETIHLAHERVVEHARSLADYFYESMLADDAAAFFLSDKL
VQEKLHASLQAWMRSIFGAALTQEFEATVAFQQRVGEVHARINIPVHLVMRGTRALIRRM
QSILADDASLSPAQRWSTGNFISEIMLFAVELMSMAYAASHDRNARAEEGYRLLSLSQNI
GTEKERQRAALLDWENQLLFGLSVGQNGSSLPRLSKSEFGLWFNHKAAHAFEGTREAEEA
KQNIIELDRMLDEADTADTTSRIELLHALRDGAKAIGYLVDALFEKASQLESGRDTLTHL
LNRKYLHVVMSKEVAYARKTGSPLSVLMVDVDFFKRVNDEHGHDAGDFVLQQVASLISTY
SRGGDYTFRLGGEEFLVVLVDATAQQALQVAESLRLRLADKPMSLPDGSQQRVTMSVGVA
AHDGHPDYQRLLKRADQALYAAKARGRNACVLEGM
>A0A3R0Q8G6|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A728RG36|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEIAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3R0PY44|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A625WG34|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379Q978|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFETINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVSLKDLDSGKEIIINQSKNNLFQYVNYNHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRS
>A0A7D8ERR9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VVFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQALGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTAAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A379R3G2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTAEKRRAFCDAFETINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGRLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVSLKDLDSGKEIIINQSKNNLFQYVNYKHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRS
>A0A379QR40|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGIWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VFYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5H7LID5|diguanylate cyclase|EC 2.7.7.65|Salmonella moscow|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A705SR34|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQ
>A0A379QYD0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQNQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A749LNY2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQTMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A757ZNC5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERAFLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0L6Z7U7|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MKRTLASKEYLVSKIEELISKNEGPFSLVVTDIDDFTNINNLYGNRIGDEVIKKLISILN
NNLSSTDIICRTGDEFNILLVKKGAERSFMELEEIRRYLSDNTFTLSDAKEENIYFTLSF
GVASYPRDAKNVIELFRVADSALFRAKELGKNRICLSEVESMVLKSSYFTKTQLDRLSRL
SKATDRTEAFLLREALDDLFKKYGK
>A0A0T9LAC6|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MRLIKRINKRRAKLPSLGKILQRIHLTVALVAVGMAGIFITLVAIFSLRVYADHNLHLIA
RSISYTTEAAVVFGDNIAASESLALIAASEEVAEAKIVDANGKLIASWSLPAHGPFHKLE
QSVAHWALSGPVELPIMHNGERIGTIIMVGHGGSLLSFLLRGVIAMLAGIIASTLVALFL
SRRMLRRIVGSLNRITEVAHDVSLHRSFGQRVPSVHIKELNELSNDFNGLLEELEIWQAH
LTQENDFLTHRATHDSLTGLANRAFFEVSLNRTLNECADKDMVALMFLDADNFKEINDNY
GHAAGDVVLITMAERIRSQLRETDFVARLGGDEFAVLLTSIGNSYDVLSIADNIIHCMAH
PITLPDGTDITTSISIGIAFYPEHAQTPVELLQRADEAMYLAKNNYHGGGRVILPQSLTH
TA
>A0A0J1FFZ8|diguanylate cyclase|EC 2.7.7.65|Peptococcaceae bacterium CEB3|TrEMBL
MKDIPAEVVERILEEVQVGLTLLDREGNLVWSNAVARRLFGWQGEGPGNILACHKPEAKE
AVGKKLVDAGQAKEWHRIMRIDNRFIENVYSFVVIPEKFSGVMMFSRDVSERENMINDVW
EKASHDPLTKLFNRQEFDRVYQNIVHSSKHGSKPFGLIMVDVNELKFVNDTYGHPAGDQL
LIQTGRILQACVREQDSVFRLGGDEFVLIVASDKDSTLQAICSRIRRQCESSREELGMKV
SLSVGTCLSSEVTRAEEVLSVADKRMYEDKAKYYLAKKGQRQSNSQLPPLNA
>A0A1V6B1M0|diguanylate cyclase|EC 2.7.7.65|Candidatus Aminicenantes bacterium ADurb.Bin147|TrEMBL
MTIRSKLAFVLGVSMLLFIALIQVFGRRVMKEQVRVQEESTVRTDIKRVITLFEEEENGF
VAFTESESFRADAAEILDPARNRSLDSHKVASVFLINQCDIIACADPSGRVLQARMFDRK
SGGERAVPTDFQARLDMIKPLRETLSPAEDFSVILAFEKIPHLVVVHPSLKHPPNAFGDG
LLIVARKIDGTFMEQLGRIANLPLRRLPTMKIGLPDGVKAALDAGTNRFTTAVRAVSEDT
ISGLVQVRDPGGAPALVMSFDAPRLLNALFNRSWTLFAGVFVGAVLLMMILSAVVIDKMV
VARLSRLAAVVKTIDSDTDRPGPVPVEGGDEISGLAVSINGMLESLHDYNEERRDLIQRL
ESDSLEDPLTGLYNRRGFLTIGREYLNLSARNKTRMHLLFLDMDNLKQINDTFGHATGDE
AIVRAAEIIKSVFRSSDVKSRLGGDEFAVFPIASSIQGLKSSLSRFHEKISEFNRSGICP
FTLSFSSGVAGYDPENPSTIEDLLARADKRMYEEKRRKTENDDRA
>A0A087D1M3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium ruminantium|TrEMBL
MLETMSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKIQPDLIVL
DVMLPDIDGFTVTRRIRQEGITTPVLYLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVA
RIRAILRRTQEQVEDDPIIRVGDLEINEDSHDVSRAGQPIELSPTEYKLLRYLMDNEGRV
LSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDGIVVEDENGEKHKVTPLIETKRGIGY
MIRAPKN
>A0A4Q4H1V6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter piscicola|TrEMBL
MNEASIVDLSRQWQWICDDFSNTDLTYALQFIQDNSFVLVSEFYKKMMEEKTASEFLSDE
IVQSRLKSSLNNWLLESFEVPFQKNFYEMVQKQLKVGEVHARIGIPSWLIIRGIRQIEKK
VFCLLNKPQQNLLSIASYIVQVLGFTSEIMSRTYEAKAEINNDMKHTYRLFSAMQDVAVQ
KDKQRGSLLDWENELMFKVFSDQTNFTHTSLSKSEFGLWFIHKAAYAFSSSDQVKEIIGG
IKKVDVLNQKIISCADKTLAIQLIQEIRNQDREILLLVDQLFQVSEYIGSGNDSLTQLLN
RRYLNTIVSRETLYARKHKTHLSLLAIDVDHFKRINDQYGHATGDTALQLLAEVILEHTR
GSDYAFRVGGEEFLLLQVATDLKMAEQIAEKIRQRIQTSEILSSTGVAVQFTVSIGVVSY
DGHPDYQRFLESADTALYAAKNNGRNLVYIA
>M5CKD2|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia SKK35|TrEMBL
MPVLPQAAVDGDLADPLPQRILLVENSRAFTGMLREAIEQRLELPVVIASTLAEADRLLS
EDGGWFLVLTGLVLADGDRDAVVEFFLKRGLPTVVVSSVYDEDLRKRVLQQQIIDYVLKN
TPGSIDYLVWLVQRLERNRRIAALVVDDSPSARGYAAALLRMYGHEVHEAADGNEGLAAI
EAHPAIRLAVVDQEMPGMQGVEFTRRLRTLRSRDKVAVIGISGNTDASLIPRFLKNGAND
FLRKPFSREEFFCRVSQNVDQLELIGTLQDLATRDFLTGLPNRRCFLEQSQRQLPQLQLH
GQCVAVAMIDIDHFKHINDTYGHEAGDDALRAVAGAVAAHARSQDLIARFGGEEFCLLVP
DMEQDEALLYFEELRQRIAALEVDIGSATLRMTVSIGLCCLRPQRDALHRLISEADRQLY
LAKAGGRNRVSCTTMASPLRPREPALP
>H1WLM7|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MFSILIVDDDPDNFDVVETCLIDENYHLHYAYSGQDALSVINVIKPDLILLDVMMPVMDG
IEVCRRIKAMGEWKGTPIIMVTALSSTESLAECLGAGADDFIAKPVNGLELLARIRSMLR
IKQQYQLLADFNTKLELMVEERTAQLQRLIDEDTLTQLPSRAQLLHKLSDSYVDSSGENY
AIAYLDCDQFKLVNGAFGYQVGNQLLRAIAERLKKHLRPGDLLCRVGEYEFCFGLKNISA
TGELTDWINGVMGSFIQAF
>A0A290HX51|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MQKKLSLIIVGTIFISFMLLMVISALSIRNLGIKNAEEKAQIIANLVQDGLSAHMLSGTM
AQREFFLKKISTAKGVDALWVVRSNSVINQFGKGFSNEVARDSIDEEALNSATVHKQIIE
DSGNVKLRVTTPYIATEHGTPNCMQCHQTKEGEVLGSISIVFDITEARTNGILNALMILG
FSIVIMLLVFLIINRSMRPLMEIFHSITFVMNKAQEGEYVRRVRCSSQEKEYQNVKFGIN
SLLDKLEGTLTDIEMTVKKFLALSPNHQPDLLLETQSIVHELSDIYQFKRTIEFDEDKEQ
VYHRIGSILQHDIGLKDFVLIESGKNDIHPNIVFDASSQKRSINLNCRALRTKQTVTSDQ
FRDICGLCNTSASHLCIPYLISSDLELLLSIWERTPEELTHTKTLLPKIQNYIDAARPEL
VSKNLTEILKVSSTTDALTELYNRKYLDEYIEKALSQAKRNGIIYGILMIDIDWFKMVND
TYGHDIGDRAIKALSQALKANIRESDTAFRFGGEEFLVLLYECEDAMVMQIAEKIRLAFE
KMPIQSNTSATFYKTLSVGASIFPKDSDSLWKCIKFADIALYNAKDSGRNCCKRFDPSMI
ETKELRNDF
>H1WLZ1|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MQPEVKSAIIRDPLVVSGDLTVMEAIACMSGVRLQCQMTDNISISESEPDLYSHLTCVIV
LQDLMVVGILTQRDIVGLAAQQQNLEELLIQEVMTPSVITVRESELTDSLTTINLLQKHR
IRHLPIVDDSDRLVGLVTHESLRKLMRPIDLLRLRLVSEVMTRNVVSANCDQTMLEIARL
MSERRVSCVVIVETQGHGDHAMPIPVGILTERDLVQFQSLSLNWENIRAENMMSSPLFTI
KPQENLWEVQQLMEQRRLGRVIVTGSRGELLGIVTQSSLLQCLNPLELYKLAELLEEKVS
RLESEKFQLLENRAAELEKQVKQRTNELVKRAEGEKLISELATKIRSSLDLQTILDTTVD
QVRQVLKCDRVNIWQFGDNWETVVVAESTNSPFSLMGERIADTCFQQNQAEIYRLGKTRV
VSDIYTTEMTDCHREMLIRLHTRAKILLPLLCGDQLWGLLNVTESEHPRQWKTEEVELLQ
ALAVQLAIALKQATIHQKLQVELQEKTRVEAELRKTENQLRKAQKIAGLGTWNLNHKTQT
LSWSEEVFAFFEIEPENFSYTHEQLISLIHPEDRDLVNDMYNQHLCDRQSYSVSYRILLN
DGRIKYAQEYCQTIYDDNNQPIISDGTIQDITLQKELEQEHIRAEAMRQQAESISREVKL
LDNILDIILAGYWDWDIPGNKEYMSPGFKRMFGYEDHELPNVPESWQKLIFPEDLPGVFD
MFEKHIKSRGKIPYYNEVRYRHKNGSTVWVVCSGKVIEWDDDGNPKRMVGCHIDISDRKN
SEIALAESEARYRSIIETTLEGVWIIDGDAKTTFVNQRMADMLGYTPSEMLGMGLMDFLN
SEDQLEAVNYLERRKQGIQEQHTCQFQRRDGTALWAIVSTTHQLDNQGNFVGAISLLTDI
SQLVSIQEALKTSEMQLSGILNSSEYGIMAFRSVRNEQGKIIDFEWLLVNPSAGKVVGKS
ADELIGKRLLEELPEYQESGLFEHYVEVVESEKSVKKEFYYNQYGIDFWFENISVKLGDG
FAVTFRDITGIKQSEKALSLANEQLNNRINELDQRHAEMLLLSEISDFMQAALTVQEACE
AISYLLEPLFPECAGGIFLMAASRDSLEMISSWGKECTSVSVFVPKDCWALRRGRVHLCN
HEKGGISCRHIQVSSTLSCTLCVPMMAQGETLGLFYLSTDSATALSEGKQQLAHTVAEQI
GMAIANLNLRATLEHQSIRDPLTGLFNRRYLEEYLSQEIARAQRQKHPIGVIMMDIDNFK
HFNDTFGHDAGDYVLQKVGELLKQKVREYDVACRYGGEEMTLILPGSSLENTSMRAEQIR
EAIASLVVASGGQHLGSITASFGVAAFPKHGSIGIDLIQAADAALYRAKADGRNRVVIIP
>A0A290HHE2|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MKQFLLEERNVTRYIIAAIVIFAMIIGFIIMALSSLRQEAIQTHRHIANLHAYTIEEHFS
QILQHASITIDRIPLLSNESISEVALAPVFTELLHNAPYLRSLSLLNDEGVIVASSHELN
IGKKVSIDNFLPIPFGETPLLRIGVPWSGRDFDNAHSSSIEKPIPSSEITFLPLLKKVFF
EDTLYYVIANINIDYLTNRYTNTLPTDQGTVSLWRLDGTLLVSTNPQFYLGSSHYNMNHL
QHVNEDFFTHLQKETHTLLDVFRLAKVFPFIVEIQTNEANTLGYWDKERQKILSIITLLI
TLTGVLTLALIVRYYNENSRQREQLSYEKQFRIAMEATQTGLWTWNLKTNQVTWDPQCFL
LLGYQPNSFETPWDKIYELTYPDDANDMLSSIQDQILAQSIFLIERRMKAASGEWVWIQV
RGKVIEFSELNEPLLLTGVYINIDTQKKVEQLHLSAVAFETQEAILITDVHEKILKVNEA
FTRITGYSDNEILGETPRILHSGYHDKAFYQVMWKALLEEGFWQGELWNKRKNGEIYAEF
ITITAIRNDQGTITHFIANFNDITTNKVEQLKIQELAYYDPLTRLANRRLLEESLHKTLK
HCLYENHLGALLFIDLDYFKELNDTFGHDAGDMLLIQTAARLKETIRESDLVARLGGDEF
IVLLKDIGKQHGSANHLTENIAHKILSLLCQPYALAHGNYQLGASIGCTIFGNDPKKDST
MLLKEADLAMYQAKEKGRNQVCFYETSS
>H1W671|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MPSKSNFGHVDEAIALLERLKALGIKLSMDDFGTGYSSLSYLHRFPIDTLKVDQSFVRRM
DDSQQNTEIVKTIIMLGHNLNMDIVAEGIETEGNVQTLKNLNCEYGQGYFFSKPLPVTAL
EDLLNRTLYQS
>A0A5M9J4P5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MTLDPPTILALTVALAAAAALYLAIEWRSVREPSLLYWSAGFAIITIGSTLALLRSSGFL
MIGIWFANGLLVSAHFLFLLGVARFTHVRLSRLWLLMLFAWFGMLMLPADLPWSKAMLGV
QSLLVALPTLRASFLLRPHGKSLSIGAVQLRYVLLAHGVFYVAKALSVLIPGTLIDLAAF
KGEIIQISLVEGAMAIMLIALSMTGSERYRREQQIARLAARDPLTALYNRRALDLRAPRL
LAQVSPSQPGALLLIDIDNFKGVNDHHGHTSGDRLLIALSEMIRSLVPQGALAARLGGDE
FVILLNPVSKEQVIELGSDLREQFQQLAAQTFATPERVTLSIGANLFDQPALSLAALIEQ
GDTTLYESKRGGRDSIRLVDRTGVGAYR
>A0A2P8B185|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MH33|TrEMBL
MDHERVVRDVTVRLPMASTALEACQWTVAALARHTPATISILLQVHDRLRCVAATGAWQV
FSTVPLKTGSDNADAPRRDPEPSIVARVYDSGEPATVPDVTADPDYLPVRPDVTAEICVP
VRDRAGRPLGVLDLQWSGPVETDRWRATTQRLADRLGARIGALGGPPAESRSEKLLRHAA
AMTTAPTDWDLMTAAITAARDVSALSAAVLILADRREPRLGAPTGTPGPLEARIRAELAE
AGPAALGRMIARAHRHGSAYTLGEAGHPPTEDYLPLTRAGARTLVAVPVGPPDGGGVLLV
ADERLLRPDPTTVNLIELLAGQAWTCLDRLRTLARLREQASSDPLTGLRHTGPFGQRIAS
ATPGRTALLAIDVDGFKDVNDTYGHQAGDRLLVGLARALEGALRQGDELYRTGGDEFVAV
IEVSRPEEAVRIAERLTEAARRAGRTISVGVALPRPGETPERTLRRADQALYAVKQHGRD
GVHLSAA
>A0A8F9TCD3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MKLRNAKTRPTLRSVLGRGHLSVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVGAAVVFKDRVAATEALALIASTEEVAEARVLDLNGNTLAHWVRPETGVLSRIELELAH
TLLEEPISQPILHQGQKIGTVELSGHGGSLLRFLLSGLAGIIICTAISGWVAIYLARRML
RGIIGPLHSLADVAHAARSERAFDRRVPPAQIAELDSLGNDFNALLDELEAWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRSAAKLNERVAVLFLDSDRFKDINDNFGHAA
GDAVLVAVAARVRAQLRESDLVARLGGDEFAILLSPLHKLEDAQRIADKIIASMDQPIPL
PGNTEVLTSLSIGIAVYPDHGATPGALLNAADVAMYQAKRLSQGGQHTAESEHPAANVQH
RS
>A0A379XM46|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAALVFSDNAAVAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARNSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLHGVHSEYEVQRICAALSLAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1S8LB11|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MRNTYFLMILVISIIVLLVLAIKVLRNKNNDKVSLFFSIFLIIIIFRDVADAALFCFSTK
SKVLINVLIFIREGTNPYVPIVLLFMCIAYVNSENNFFTFKYLRYLIIPIISTIMLLLNS
RYHLFYREYNMDGSFTWGAYGLYIHIIYSYICILYGFYLLLKHSIKHSGFFSKQVLVFIL
GLLLPLVVNVRTAFIGNFTPDDSIIFSPISVILCWIAISRYGFFNIKPIALRTVIDNIQD
SFIICDINLKIIDYNKSFENLFCSTKIKRGANIDVLREKISDNNLQIVDDVTKALKLGME
ETFTHKLIFKLKEKCFQVQYTPIYEFNRRLGSILLLKDVTEYIKFTIELKRQNKEITELN
SKLKFLAERDGLTGLYNRRYFNELFYNEMYKLQHYNNDDQIDIGISIIDIDNFKRINDTY
GHIVGDEILKQLAEVITKNVRKEDVVCRYGGEEFVVIFMILSSKDMVCICEKIRKTIEKF
DFYNSVSPNKPLHITVSIGVATYSEDYNGNKDDILKAADDKLYKAKNNGKNQVVS
>W6M1T9|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MLACLALLAGSAWLNSAQPKDPSSDNRSTIPPGQPTKITVVDDRSYPPFAFLDAEGRPRG
ITIDLWTLWSKKTGIAVEFYLAEWETALAAVREGRADVVGALFRTPQREEQFDFTNPYHN
IATSLFFHQEIQGVRSIEDLAGFVVGVVKDDSAEELLIKQYANVKRQTYPGAEELVKAAL
AGDIKAFIADSQVVRFYLAKLEAGSEFREALTPVAVNALYAGVKKGNTRLMGLLEQGFQQ
VSAQEKIAIIENWTGISAFSKVPWVALRTLFTLIAAILCVMVLWNVQLKRKIAQATSVLQ
KRHEELQNSERNYREIFNATHEMIFLHDAREGRILDMNEAAVKSTGYSKQELLGQSIAKI
TVNPPATVDESPSYRIRKAVTDGTLVFQWLFQRRDGETFWAEVALKSSRIGGENRVLAVV
RDISMHKQAEAALKNSEATLQSLFSAVPVGLAIVQNRRLQAVNERVCQISGYGRDVLLGR
NMRSFYENDTEYQRVGEMLYQRLPPYGLKFVETRLRHANGSFRDISVCAALLNPQDPTGR
VALTIQDITSQKKAQSALRASERRLRNIAKNIPGVVYQFYVRPNGQTGFYYISHRAGQLF
GIGRRLNGAFNRFIKHVAPEHRKALLASIEQSVTTQSPWSFEWRFIKPTGESLWFRGASS
PTNFGEELIYSGVVLDVTEHKLVEQRIAHLAYYDVLTALPNRALLTQRVELALALAARHQ
RQLALLFLDLDRFKDVNDSLGHSEGDLLLTQVAARLQALIRAEDTACRLGGDEFALLLPD
TDQNGALRVADKLLEAFQQPYNVAGHRLRTTVSIGIALYPHDGANATELLKNADTALHRA
KREGRNVRVFYDRQMNAATFQRLVLEGELRQAIAMGELRAYYQPQVRLTDQTLVGAEALI
RWQHPQRGLVSPAEFIPIAEASDLVVALGRWMLEAVCQQLYHWHHSGLVPPPVAVNMAAR
HFHSPHLPSELHQLLETYGLPRHALELELTESTLLGTEETPEAALRAIEQLGIKLAVDDF
GTGYSNLAYLKRLPLAALKIDRSFVRGLADDANDRILAATIIALGHQMGLIVVAEGVETE
QQRQILLAQGCDLAQGFYFDRPMPAEAFADRWLQQTVGDQNLLRQRCSPKHSPTVSYSGQ
PE
>A0A0F3NHQ6|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum str. ApNP|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLTKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNVLQESF
QETTILSDPIQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSVLLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMYFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>A0A2H6A508|diguanylate cyclase|EC 2.7.7.65|bacterium HR33|TrEMBL
MTFPSRTVPARIVGISLASLAVPLVTALAAPDWLAEEEGLLIWLWAFAPAFLFAYYRGLR
GVALALAAGMATLSLAHVELILLESTPPNWNLLFAAVSAYLAACVGAGIVAEMLHRERAK
AERLALVDQLTGLPNRRHAELTLDAQFAAAGRGQKLAVVLFDLDLFKQINDRHGHKAGDA
VLRIFGQILRRNTRRMDLSARFGGEEFITVLSDCDPGGAELFAQRVQRELREARFGWGSV
TVSAGIAFYEEGMGSYEVLVAAADRALYAAKHAGRDRIEVYRPPKVAAVAQGARPASERG
EPRRSASIVVIDDDLDVLRAVTRLLQRAGYRVEGTDDPQRVIALYRDGQTRPDLLITDVM
MPRMNGLTLVDSVLRLDPGVRVVYLSGYLQEEARWAGLPGAASAFVGKPVEAERLIAAVR
EMLERKPEDDSSASAGRNAQVPEPK
>A0A5P9BEJ1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MNLQREGMTINQRNIERYFELVNLTTEQVQTLSHHLAQLSINHSEFSDRYLHQLRTKTRF
SHPEVHSCLSHGPLCNAIKHHIQTWLTCSYTQKNFNYHVRLVTELNAHHVTVAEFLLCGL
AVKANLLSQLKHSLHTHHIDSARLIRDFEKWLTVDEHILRDLELNHQLEKLRQATSFKDE
LTNVYSYAVFLEELDRAIALCDRTCQPLTVVHFDINQLNTINHKHGFQVGDAVLQQFASV
CIEQLRKTETIARDDDEFFILLPNTSLKEARNVFSRLVELFDNASEIPVTLTAGASSYVP
DSDLTLEQVLKRTRAQLARAKTRSASNDTHHCCLDIDGKMDNVLHFAR
>L3Q8R7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE75|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8F6L6T2|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. WY228|TrEMBL
MGGDDVRLRAVVSLAQTMAAAYTPRESWRAAALGACEALSGSFAALSVWERDRGRLRVLV
NAGQRAEGEEEFPEEEAYPVHEFPEITEFLHERWAGGGEPDAWVETADGLPGAGGPARGA
RPYCHQRVAALRRRGRGCCVVAPIVLHGRAWGELYVARPAGQPVFDRADADFATVLAAVV
ASGIAQTERLEEVRKLAFTDPLTGLANRRAVDIRLDEAIELHRVDDTVVSLVVCDLNGLK
AVNDTHGHAVGDRLLERFGSVLSLCGAMLPQALAARLGGDEFCLLAAGPPADAVVGVATE
LCDRAAVIELGDGVACGVASTGDPIGPVRSARRLFRLADAAQYRAKAARSLGPVVAGRDG
EVIRLADSPPKSAHDRRRLRGNRP
>A0A378TLH3|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MSADPAPVVPVLPPVEFTDADYLRGMERLLQAVQELSLARSIGDIQLIVRTAARELTGCD
GATFVLRDNGKCFYADEDAIAPLWKGSRFPMEICISGWAMFNKAAAVIPDIYLDARIPHE
AYRPTFVKSLVMVPIRQLDPVGAIGNYWAHQRQPSAPEVSLLQALADATSIAMENVRVYG
ELEQRVSERTAELERAYEEIRELSITDELTQLYNRRGFFLLAEPTLEAIRRDHRDCVLGF
IDVDGLKQINDARGHAVGDALIADTAHILKSTVRPSDILARLGGDEFCVLITDPYADPTA
VRRQLLDAVALFNEAEVRPYELSVSVGLMLVRADDIDDIDGLLNRADELMYLEKKARLSG
>A0A6V8LQL2|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MLLPPSWPLRSHLRVHALVSTLLPCLLMAGFLSYYLSERLHERYAAEMLLTLKLQRHFVD
TWLADRQRDVIRLADQPELKAPDPAQAEGDFRRFVAVMPEFRGLVYVDALGLTVLDTVAK
PGLYLGDRVYFKEGRQGRPYITDLIVGRATGARLIIFSAPVQGPGGEFRGIVFAPISPDV
IVQAVGGARLDYEGQTFLLDRVGAVVAGDEQLVPNPGAAQPSQEGLQGEAQEFTYLRRDG
TAMMAMALPLSVPGWRLVAATPKETLRDAVRPVVGVVFAAGIVSFVVLLPLVLGFARRIG
AVVEPLADHASQLAQGRYDLPLPALPTGRVPRELDTLARTYEIMREKIVLDVSALETMAL
TDALTNLPNRRYLMEEGPRLVELCARTRLSCACLLLDLDNFKAVNDLHGHATGDLVLAGV
ASVLRRTARGADILGRLGGEEFLLLCADTTREDALILAQRVREAVKDARIAPLNAGGVTV
SVGVATLNTFVQPSGVLFDRLLVAADTAMYQAKAAGRDQVAVSPCDPDTSACTPDKR
>A0A653UNE7|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MLSQYKQSSPARPRASRIGVDPRACILALSAIALGLATAAFAPVVRLPPAAFLAGSSLAL
LLALSLSAWRRHARAQRSLNASRSGWRDFQQLAGIGSLRYGLDDGIWHASSTFVALTGLG
TGAGHGPAELFGLLGRRDRVRLQRAVRAAWIDGESFDHDMLRLSLADGSTRWVHLRGRVS
ERGKGAMVLLCTIQDISRRSQAVSAAGDPDARDALTGLPGQGALAGRLLLLQREARQRTG
LLMLDLDHFSMFNAAQGSDRGNLLLRAVAARIQFRLGPDALATRVRADRFAVLLTDLPWS
AGAAHEHVVRVAEALRDALAEPFELDGLRQACTASIGLALAAPDTPPARELMRRAENALT
QAKAGGRNLIRLYDPAMEAVEAARLALENDLRLAVSSGQFELHYQAQVDSADRILGAEVL
VRWRHPLRGLVPPASFIPLCEGTGLILPLGRWVLETACARLAAWSGDPLLGDLTLSVNVS
AAQFTEPGFVDQVLATLAHSGVDARRLKLELTEGLLLADTEGVIATIRALKDAGVGISLD
DFGTGYSSLAYLKRLPIDQLKIDRTFVADVLSDANDLAIVRTVVALGRSFGLEVVAEGVE
TDAQRALLTELGCRVFQGFLFSRPLSLAGFEELVGRCGRIAAAREAVAPVPEYALSCVRG
DNMRHADE
>A0A653UX86|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MHMREGRGERFAGAPALGAEPVTAPPDERLPVLGPAFSACVLILGIWDLVANGSQTPSSL
LLRLALVLLGIPGYAWPGGAASTLGRWLLVFTTHSLALVVNAVSLAHGLTEAMPVLVISV
LVAGLAESRPRRCIAILLPSALFHAIAGALVLPQLVWLASVAASAVAVAMAMLIAAANGS
IREAAWRHEQQLLHACRYDSLSGAMSRAYLTELARRDVSLARRHARPLAVAMIDIDHFKR
VNDTHGHATGDAVIRSLVDTCRASLRQDDYVGRIGGEEFVCILPETGVDEAFACAERIRT
NVEASLLAAAGGPVRFTVSIGVAVLCGHDGWDALLRDADEAMYRAKAGGRNRTTVASDAR
CDACA
>A0A7U6F9U9|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINAHKKRFAYWSWNPADNNDTLGALVS
RWLFPVPVAQPIMHNGATIGEIRLTARDSLIGHFIWMSFAVLTGCILFATIVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQAYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTTS
>A0A653J8Q6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MDLGRDNLAFSSAVDGPFEPAARLGSAEFSAQALAGAGVGTWHYDAVSGLSSWDAETSKL
FGHDTVDQCGGEFPILQDDKKRVQLSIRQCLKKNEAFDIECRIVRADGAIRWVQAKATVL
GPCGGPQRDLAGIIADITDRKNAETKLREAEERYRLISQTTMDFVYEWDFDEDRLSWNGA
FERCFGHSPDQVETMDSLHGKIHPDDAEFVLREMRGLLESANSQIALEYRIMRSDGTYAN
VYASSHIIRDPLGQPSRLIGALLDLSERKLADAAYKQSEALNHRIVEAVTECVMLIGLDG
KLEFINGPGARAVGIQDPSLFYGQDWVSFWPARARKAVSAALSAALNGGNGAFAEATPTL
HGVLKYWDVVISPVLTDGKPAKLVAIARDVTERKEAQEALVRAATRDALTGLMNRATFQE
VLASRVAMARESGCQLGLMLLDLDHFKHINDAEGHDVGDHLLAVIAQRMREVAPANTKLA
RLGGDEFAVLMPDIGSGDEAVDMAGKLLERIRTPLVHDRRKLDCSATIGVAVFPDHGRTQ
EELLKSADIALYVAKNQGRGRAALFESHHRAEIQARQSMLSLARAAIRNQRIVPFYQPKI
QLPDRQLHGFEALLRWHDVRRGIQFPSTIAAAFDDLDLAATISDHMIDRVIEDMRCWLDE
GLAFGHVAVNAAAAEFRRDNFAESVLDRLASAGVPSSRFQLEVTETVFLGRGSEYVDRAL
KLLSREGVSIALDDFGTGFASLRHLKDFPVDVIKLDQSFVRDMKKDPDDAAIVGAVLNLG
RSLEIEVVAEGIETAEQEQRLRELGCRYGQGFLYSEAVPASAAADIIRRMMKQGLPA
>A0A7W4Y0M2|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. RAS22|TrEMBL
MTARVLVVDDIPANVKLLEARLVAEYFDVVTAEDGFKALAICDKEQVDIILLDIMMPGMD
GFEVCERLKANPDTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLIARVKSLV
RLKAVSDELRVRAEAARQIGIEEMLRSDGLMQTPGRILVADGRASSQERIVRALKPVAEV
DAVTEPQAALLKATGNPFELVIVNSNFEDYDPLRLCSQLRSLERTRFLPLLLVAEQGADD
MVARALDLGVNDYILRPIDPNELVARSLTQIRRKRYNEHLRLNLQHTMELAIVDGLTGLN
NRRYLDNHLKILFDRAAVRGRPISICMTDIDRFKLVNDTYGHDVGDEVLREFAARIRSTV
RGADLACRYGGEEFVVVMPDTPIELAASVAERLRTIVEDKPFYVRSIDRELSITASLGIA
SGSGAFGTPDELLRQADRALYEAKHAGRNRVVSAAA
>A0A653J713|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MRVLTCLLYEHDLWIVLLAALMCLTGSIVAVTLFRRTLAESGTARFHWCFLSAVTAGAAT
WATHFIAMLGYKSGVPIDLDGPLTIASALIAVGGIAIGLLLATAKDRAFSVVIGGGAIGL
SIAAMHYVGMFAYRAEGIVEWRPIYVIASLFVAAGLTMALIYRLRRSRPADRLVPTAMLV
IAIVGLHFTGMAAFSVAPIPGVSAGADSEAFTAVALAIAMVALLIVGTGISTYLLESRTQ
SESRDQLAHIAMHDALTGLANRHSFSLTLESECGKLERYGRPFALLMLDLDRFKPVNDTL
GHPVGDLVLQRVANRLRQAVREGDMVARIGGDEFAIVAFGIADAEQASALAARVVEIMSR
PFIVGGSVAELGASLGIALAPDHGGESEQLVQHADVALYSAKRAGKDRFCLFETEMMDAM
QRRRFLEVDLRRACMRDEFEVFYQPVIDSKTGIVTGAEALLRWHCEGRGDVSPAEFIPIA
EELGLVSRIGANVLQQACHDATTWPEELDVAVNVSPVQLLDPRLPQIVAQALLDSGLRSD
RLELEITETALLGDDEAALRTLNHLRDLGVRISLDDFGTGYSSLSYLHRFPISRIKIDRS
FIRKLPEDPGSASIVRAIAQLGESLDMKVTAEGIETSEQLSFIAEHGCDHVQGFLISRPI
RVGDFLALVKARTASIAA
>A0A380PXV0|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSSIKDKSASQIKNQTNAVKLPTLGRVLGKIHLTVAIVSVATAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDKIVANEALSLIATNEEVAQAKILDVKGREIASWTLPDD
GPIHYMEQSVARWALPEPVVLPMVHAGTEIGKIVIVGHGGSLLRFLLQGLAGLLICLVLS
TAVALFLSRRMLFGIIGSLNRITEVAHNVSRHRSFGQRVPSAQIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAFFEGRLSRTLKDCKTNEHAAVLFLDGDRF
KEINDNYGHAAGDVVLTTIADRIRALLRESDLVARLGGDEFAVLLAPIHDTDDVLTIADN
IIESMTQPIVLVDGIEITTSLSIGIAVYPDHAQTPEELLQRADEAMYQAKKGFRPSERGI
VHQSGLIYTEDSQTESLG
>A0A4U8Q9Z0|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MEKDDKKALSMQSFVFDSLLNNMNAVLYVSDIETDEIIFMSKNMQEIFGVENPEGKICWQ
ILQRGMNHRCSFCPIARLLEQDSETPFFVWEEENTATGRIYENYDSLIRWADGRLVHLQH
SVDITEFKRITEIASKDELTGMFNRRAGKLMLQEALKKLQGTERTLCVCLYDLNGLKQIN
DVYGHYEGDKSISYIAQAALDNLTADDMAFRLSGDEFVIIFMDICLEEADGRVRSIQKDL
KQIVKEKAVSHEVSFCYGIVEITGKDEFSVSKVISLADEEMYRQKKVYHIKKAEERLSGS
LSEYQAAVEDFDYDKEHLYDALMESTDDYIYVGNMKTGTFRYSPAMVEEFGLPGQVIPNA
AAVWGSLIHPDDKKCFLEANQEIADGRVNSHNVKYRAQKPSGEWIWLRCRGYLIRDKYDI
PELFAGFISKVKDPSLD
>A0A4V1C8L7|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MKTAKKTFFTQHPFIELEKIISSNNLILFVLIVLIIAINSAGFLSVKWLQSEWTQQYTVY
QTKQKLYFDLYRESGYGGFIHAFKNAVLRKKTIYLKSLSTHHQNVEETISKLKSLASTQA
EQNKLQDVQNTFHHYWQKYPLLEKAIQENWSAEKLDNRVYVNDKAALEALNDLIALNQKN
FNRSVARNNQLIQRVGVYETISLGVILFFSLILFFSMRKKAGLVNNVLKMQKEAVAYKEL
YEATLDSMVDACIITNEKGIIENFNQIALQRFGYTAEELMGKPIEILIPQGEHKRNHAHY
MASSSMHKKVLFKGRELKAITKHGELLSSEITVTPLKQSEDLKYVGIIHDISDRMKLMEQ
LGSLLNQLRDEATKDYLTGLLNRKAFFEQAHQIWLSAKEQHQPISLLMIDIDHFKQINDS
FGHDAGDRVLIEVARVFNQNCREEDLICRYGGEEFVILLENKDEEPALEFASRLKKIVEE
ISVKEQSEEIRFSISIGVATGDALELNSIESFISQADQALYQAKANGRNRVEIFHTEEKK
R
>A0A5W5KNF3|diguanylate cyclase|EC 2.7.7.65|Salmonella ordonez|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4P7NZD1|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MSIKKEDMISLEKMPAVLDALPDPAFLFSRSGKYVAVYGGRDNRYYHDGSGLVGLYIADL
IEAEKSNWFLAKIEEALWSKKLLIEEYELSNKDVKGLPDEGPQNPIWFEGRIQALDFLVD
EEEVVLWVASNISERHDLEVKLRALSDTDQLTGIFNRRRLEHDLLLHFDAFAQHATPTSI
LMFDLDNLKQVNDRFGHHAGDDVILAVTRICRSHLNKNDIACRFGGDEFIVVLPGTELEE
AVSLSEKLSAEFKRGLTPFCVDGIKVSVSMGMTTIKPVDESYQDTLKRVDKALYTAKKNG
KNQIVID
>A0A4P7NYP3|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MSIQQFFVKTDYRFVFLIPVYFLTVAVFAVIAFFNQEWPLFSVLSIFTLAIFLFGIYIIK
RGLTWWSKAFMLLVNAAFVIFLMVHGGHNHTGYFWVFPILVATIQILGALSGIFFACLLV
LMIWLLEKWGMTDLILSSRFYFASLALVFITGIHEMTLENNRKILKKQVDDKEYENRLDP
LTKVGNRRLVDYELERINAQGMDGLAVGALVVDLDNFKKVNDTLGHSAGDEVLKTIANHL
TSCVRPSDKVARWGGDEFMLLLYGISLIDVERVAKRIQESITHDERLESLDVSVSMGGAI
TSSDYSELFKAADRNLLSIKNHTKNSFKITML
>A0A379W471|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MYSAGIRHCLLLTRYLHNGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFN
SLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFL
DGDNFKYINDTWGHAAGDRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQ
RICAALSQAFNRPF
>A0A509DZ28|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MELSLNKYANSYEREPDHAQIIARQQHKRTDRLGISFVYQLGTCSLVLAATLLGELHWLV
PSLFLVFIFANTACLLLVFRSNLNLYFKDPSLTTFQILLSYVPPIIIMYFFDSSQARAAF
IIMALVPISFGVFLLTTKQFLFIGVTLLSFYALVMILLAFTRPQVINPNGDMLQTYALVL
SIIEISLIGGYITGLRTKLTARNKELESALNTIQDMANRDALTGVYNRRYLFNKLEQYAE
EQQILSVCLMDIDGFKSINEIHGHLNGDLTLQRIANSVTSLLDESESFGRYGGEEFLLIL
PNTDIDIAKVKADTLRHFISKIAFPEIGQDFRVTVSVGIAEFKPDEDIKETINRADLALF
EAKSLGVNHSVIKEAFPIGDFKSP
>A0A1C5XP89|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MTMTINVAVFLALILEIVILYVVNLQDYKRTSQMLMNQTMEVIEKNDSREKEMLESLKED
YKVRVNAVAYILDAKPEVENDLNELKKIAAFMSVDEIHLFDENGVIYGGTIPKYYGYSFD
SGDQMAYFTPMLQDKDLTMCQDVMPNTSEGRSMMYAITWNNSGTKMIQVGIEPKRLIDEM
NQNQISVVISNMPMYTGINIFVADSGDGKILGSTKAAMVGKTLNDVGISRDKVTEQADVP
AICYRNIDGIVSRCAFDRTDDYIVVVTCNLLSNIKTDVIIMVIMIVYFIIAAKALASMFT
KLDRVRRSAYTDELTGCFNRKAYQENVEEYWESPDMVYISMDVNGLKKVNDHQGHAAGDE
LLQGAAECMMKSFNGYGRVYRFGGDEFAAIVFADSRRLKKIIDDFKERMNKWSGKKVADV
SVSLGYAEKCERQWENFEELAEHADERMYACKAEYYSKKGEDRRKLQAAHNALTKLYTKV
LIINLTQNSYQIVSIDRESLKNSVFSAKLSDWFATFANSDELYPDDRQAFLQKTSLQNLK
KNINGTGKSYSIIYRRKYGEEYKDTMMEILAAEDYTDDSQVCYLCVRCLG
>A0A3Z0VBP7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDQLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3X9IRP3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A381DK30|diguanylate cyclase|EC 2.7.7.65|Campylobacter sputorum biovar sputorum|TrEMBL
MARFKHKFYKINSVEEVPKPNLDEHQYFFIVDESSTLSIKALKEHAGKYGIIVFYGKNTK
NLPQDDIKNFDDIWISISSELDKFYFERMLKIIADQKDAWLQKNWLESAINSLPDMIWFK
DMQGLHINVNNSFCQAVNKTKDDIRGRDHYYIWDIPKEIYENSDYVCVETEDSVIAARKT
VLFDEEVMKTDGNLIKLKTYKTPIFDGDTIIGTVGIARDVTQEYEYLEKIKYLAIHDQLT
GLANRNQLDIFLSKLKTSKMSIVCMDLDNFKGINDSYGHQTGDKVLVVFSNLIKEVFNDA
LNVRTGADEFIISIFTDSSNIKNILNRVQILIDKFSDICKKDFRFQRLSVSAGIADGKFG
HGSFDILFKHADNALYKAKRKKKGGGCYHNDKTKH
>A0A447TNC2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MSSAVLGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHMFNESVATNVTVSIGIAPL
TDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A8F6MV56|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKEPEVLKTYQAKEGELKNIEHKVGQLKDTGATGEELALLYEGLKIVDGLQD
EQQAAIASVARGEEQQAIALLFGKSYELETERAQSQIDHFRLLLDKRIIADAQAATKTSK
TLRTLSEVMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPSFSQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVMNVAELFAP
NIAPGVSGHLYILERDPWQMRCAAEWLSPEGEKKPFHPDECWAVRRGQSHPPVNGEPDIG
CYHLPESQAQQSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTFRTQMKQAMRNDEPVSCLMIDIDHFKSINDRFGHEA
GDLVIKSVATIIQRAVHDTGLAFRYGGEEFLVLLTGADEEAALAAATEIYNGVHALSLRY
GLSEIGPVDVSTGIASYPQHAQSDNLLRAADVALYRAKELGRARIVSFGRLEAG
>A0A377CUU0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFNAKLPMPTGPVHRCQC
>A0A4T8SYX3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A6L6I2Q6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVLYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTINSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSTLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A024L170|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSPEQRRAICEAFESANNTH
GLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKF
HYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQR
TKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDI
IINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHF
RLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLG
HQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIA
PQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A8F9DUI6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAAQIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8H1S5Y0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADVSSLRERIQQQICGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A6L6ZZP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSAALV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6L9DDS4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTALHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQQADAHIERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIFDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLSLVMDTLSGIGVE
LIYGDVIADAQPLDLLVNNSYFAIN
>A0A826U1B5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLREFFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6M9QTJ1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEELFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A827ZCJ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTCKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A826KYG1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTRLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRIGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGYQTTMTLSIGYAMTIEHSSAEKLQELADHNMYQAKHQRAEKLVR
>A0A5E8P331|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTNQKTR
>A0A4R5JY38|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. H9|TrEMBL
MSQPPATPKPRRFLPQACARPRRMVVLCFLIAFAISLVLAGRQYYQLQQHELEIREHNLQ
LQALAIETVVFSGKSQLQFLRHIAERLLIEAHVQPAMRGHEAVLSALRNRQQPLWGLTVP
KSDAPVLAISDAAVADIHGLSRDPQQLEEDLHLSRVMSQVLPAQFQGEPNLARIMFLANS
GIVVAYPALRDEQLEPILRKFASSPLMSLNRANAEDLDIAFYPMPGTNLGTMPHVLLSTP
VYLNAVMRGALIYDVPQTKLQSYLYQTTGNDEQHALIDNEGNLVASSDQVFKSPEGSWLS
SLPDANPRLSLPMLFQRDHGTIKLENGYLQFRELQGIDLMLTNYISATDLRAAVNRQIDI
LFYGVWLLLALLMILTLYIVDRLFKGQLRLNRQLREMGLVDGLTQLANRRRLQSDFGGLL
QRLRDDQPVALWMLDIDRFKNINDTWGHSAGDEVIKHLATLCRALVRPQDLVVRYGGEEF
CVLMPDTTLADATLVAERLRTATAQSVCVPEASTLLAGAPSLEIRLTVSIGVAELRGDNC
QGLEDLVATADRRLYAAKKGGRNQVINRD
>A0A7H9LTU0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASMLLFSTSSLNMTWTAINIIEAIVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGALIILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRAYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGKPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDIAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSADTSRSAIEQDVVLHCRSSGSYDVHYSITPLSTLDGSSIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVHSRHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFMWEGRLHRVGASAGMTLINDSNHQAAEVMSQADIACYASKNGGRGQV
TVYEPQQETAHNERTVMSLDEQWRMTKENPLMMIAHGIASPRITETRSLWLISLKLRSSK
GELIDEQTFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSVAGPHCVTLV
DELLEQLEQSSLPPRLLHLIIPAEAIFDHGLAVQKLRLAGCQIILSQVGRDLQIFNTLKA
NMTDYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVLDTLSDIGVD
LIYGDVIAEGQPLESLVNSSYFAIN
>A0A7B1MMU2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGISLSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWFSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESACFI
ATRIISAVNAYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQRRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRTVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H9JLN1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVASLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8H8ZM87|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAATHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3J0R0X4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
RWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSADARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDL
HNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A376X1D3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTLCISLFFVFGGPIVAHILSSHYESYNLHIAELTNENGQVVWKASYVTIMIFMWLTLLS
VNLYFNGLRYDIWNGVTVIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFM
CHIFSALRVTKNIAHRDPLTNIFNRNYFFNELTVQSASAQKTPYCVMIMDIDHFKKVNDT
WGHPVGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVER
LTGDNPEYAIPQKVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNF
CESP
>A0A376M7P4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFARYVWLNRLHYY
AISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKYESVSALRLFN
YCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFK
AEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLV
ANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQ
VYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAQHIQKIVG
DKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGC
ASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A7D7H7X9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMSSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A5B9A8Q9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTPATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376L2P1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWA
FVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGA
GGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYPLLFGWVSYQTAT
KLAEHKRRLQVMSTRDGMTGVYNRRHLGNYVTQ
>A0A3F3NUK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLIFWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7T8R1I3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTDTHQCLAGGK
>A0A376KU23|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAGVFARYVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDK
RLGKNKYEPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLI
VPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQ
VTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAIN
SLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHEC
GDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTW
QQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A376S7T7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRI
>A0A5N8HJN9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLD
>A0A376LNY7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDLHAEEFLSNEQ
VERQLKSADGTLDY
>A0A377DUP3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDV
GPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLI
FLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTG
LYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVL
DGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNI
NDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVH
FQVGSINLSTSIGVAHSNECPTSNA
>A0A7D6F1B9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SRADRRLYLAKQAGRNRVCASDNA
>A0A376Y465|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQIFWHPGIHP
>A0A376L132|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIG
RFGGDEFAVIMSGTPAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYR
EVVEIGRFGALQSKESRT
>A0A7W8JVB9|diguanylate cyclase|EC 2.7.7.65|Deinococcus humi|TrEMBL
MLTNPLLMNLALLVAGLFTVSLTYVRASVSEAWTRLLVRYALMVGTSVALMVNTIPLGPG
LLYDFRTVPVALASRRNGWLAGLAVALPLGVYRWLLGGLGQVPACINLLLVALLAGWGRP
AFTRRSGNVGPALYTRWREALQIFAMANLTTFVAFALAAKPVAEALGVYTLFTLLSTVGM
VAGHLVVQTRLSALANAATLGQLAFTDGLTGALNRRQFDLDLPQAGPASYLLLLDLDHFK
QVNDSHGHAAGDRVLGALADVVRQSVRPSDRVYRLGGEEFVVLLHHCQPDAALLVAERVR
ASIEGRLAGLAGVPGVITVSGGLVPARGAASLAAADTWLYAAKAAGRNRMFSWLGAGENL
MS
>A0A376W8P6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAGTQSWHHHISEHANSLTGWI
ILWHALRRQQ
>A0A378C469|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MAKWSCTPTRGALFKPFVRDELMDKMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDN
ATLVNLTRHETNLVIGGFTLAAIIIILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEA
MLSKAIETNKQRELSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKS
INDTWGHLNGDIVLRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWR
INVERRTWREDGLTVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A827W0G3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLHQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7B6VM45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRAHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6D0I963|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFA
>A0A376LM10|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAME
HDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTSMLLL
SWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTHQHPFSVIQV
DLDHFKAINDRFGHQAGDRVSFSCCRIN
>A0A377D012|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMILIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTSAIS
>A0A6D0DD03|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDTAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAIKH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376PVV9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKTSATYRAAERDRLLFRYLRDERKRYVT
>A0A5X5NN78|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Colindale|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A348AGQ2|diguanylate cyclase|EC 2.7.7.65|Methylomusa anaerophila|TrEMBL
MQANKEIRSSLPWDCGPAYAQMLLRIISVIFAFFPAIYAVAIHEAGWFTTAFLAAAYIAY
NSWLSWRRILPQVKELWIDLSLVAGMTLLDAVFVNILYHLVLARMVLRVGRQGAWKVTIV
VAAVFLAASVIGRPALSIAAVFPILYNIIGFATLSFTAIFAWRVMDKQTKNEGRIAELVH
QSDRHYRLALTDELTGLYNYRAYQERTPALEEYILIMLDIDHFKKLNDCYGHSFGNDVLK
TIGDIIHRGIRDEDMAFRYGGEEFAVILPNANLVLGLKIAERLRERVESWEFYYDKCTKV
PLTISVGLSLKKSGITGQEAFRQADIALYRAKRQGRNNVQCYQAWDDLSERTLNQA
>A0A3P5XLS0|diguanylate cyclase|EC 2.7.7.65|Filibacter tadaridae|TrEMBL
MWGIKRSTIKLFVVWLLIVPPGSIYLYSTYPPTEVNWLSIAFFIVFGFLTVRFPIIRNGT
PVFLVLWLTIPAFLLYGIFTEMIIMQIALLATLFNTSNKNPISIRFYLNSLVFFFLSISA
AWVFRLVGGEIGSDEFWPLILAVFCYQVAHMVFNDIFIKLVAIYKKNSSPLFTKEMIFDY
GMIFVILPLSLTQYYLLQFVGIGSFLLLGIPFFFIILVIRLYSNSETINESLQKAGDIGH
GLSDMLTEKAVIDRFVIEVADMFDSSFSYLFDHVEGWLEPIRVYKHQTFIDIEFDQMVSG
QGIAGLVLEKNQPIIYSKKAEWELIGKGTAQDSIESVLCVPISRNKKVESVLLLASEKIN
AFDDYQLQILDLLCSYFAVAVEKARYMQEAVTRSERCALTKIYNYRFLEEKLIYEMDKLQ
KDMITNLSVIMLDIDHFKNVNDTYGHQSGNDILYQLARKLEDLLPTGATVGRYGGEEFVY
ILPNMSKEMTMEFAERLRAEISQSGFLITPDLGDDKQQLEVTITLSIGVSSAPEDTDEAM
SLLRNADRALYTGAKHAGRNRVASYVK
>A0A1Q9R3T4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MKGKRTLETPRLLGLIWPFIAVVLFQALLGSMSLYALSAMRAYVAGESLWSKGQKDAIYY
LSLYVDTRDEENFRKYQQAFAIPEGSHRLRLALDLDPPDLEGARQGILAGGNHPDDVASV
IWFYLNFRHVSYLEKAIDRWQVGDSFLQELDTLAQEVHAGIRANQATPWYLAEWKRRIVA
INDNVTPAARAFSDALGEGSRMLLRLLLLINLATAVFLIALAWLRSSKLLAQRQAFASAL
QVEKERAQITLASIGDGVITTDVDGCILYMNPAAEQLTHWDALHAQGLPLAALFSLLDDN
AEKDSLTLTEHILNGALSGGSEHVRQIQRLDGSTVAVALVGAPIISEGRISGTVLVLHDM
TRERQYIANLSWQATHDALTGLSNRREFEYRLEQALNELARHSGRHSLMFLDLDQFKLVN
DTSGHAAGDELLRHICAVLQSALREGDVLARLGGDEFGVLLHDCPPEQAERIAENLRQSV
QSLHFVWKGRPFMNTVSIGLVHLAQAPETLEAALRAADMACYMAKEKGRNRVQLYQADDT
ELSVRFGEMAWIQRLHIALEENRFCLYAQEIAALHPEEGNGGHLEILLRLHDESGRMILP
DSFIPAAERFGLITALDRWVVNSVFGTIRQCLDEGAQAPLAMCSINLSGNSIGDDKFLEY
LRRQFCEHAIPPELICFEITETSAIADLGSAIRFINELKGLGCKFSLDDFCAGMSSFAYL
KHLPVDFLKIDGSFVKDMLDDPINRAMVQVINHIGHVMGKRTIAEFVETPLIEQALREIG
VDYAQGFLIERPQVFTCASLQRQRDAARPLLFGSPGTLR
>A0A1R3TLU6|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MLAFIDHYVKKACSTNRFETRRDVLSFALSITICVTIAADVLNVVAHYSLDGLGWLPYDV
VPAATVGVIISTLVASSLTFSITYVVGLAIHHLTISRATFERLSRTDMLSGLLNRRAFLE
EAMRAPANSSLILFDIDKFKSINDQYGHDIGDQAIIAVATNLSEIFAHCKAVARIGGEEF
AVLVSALTPTERFALAQRCRELIAAQSFEAGSSRFHVTISGGVADQEDHPTFEALYTACD
KALYLAKASGRNRVVHSRDIQSLERPEAHKARVPVKRRSIQK
>A0A1V6AW27|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MIIAERRKQKRRSEDIRGDDNLFKRFEFLIQNSRDIILTVRQQDRKILEANKSALKAYQY
TITELRSMTIDQLESAESKDQVKLHAGPDGRHEMFFETIHVRKNGQTFPVEVSMQKTLMG
NEKILVSVVRDISRLNESQESMQESESNIRALLNAVTESLLLLDKDGTILSANDTFAKRL
RIGMDKIIGANYYDLLPADTANERRRQAENVIQNRIPVRFEYVSDKRWIDQVIYPVFDSL
GEVVRLAFFGADISRRREMERELEAMALNDQLTGLYNRRGFFTLATRELKRAQRSKKNLL
LFFIDLDGLKDINDQFGHEEGDRTLTAAAKVLTQTFRISDITSRIGGDEFAILVVDADET
LIEKLLLRLYRLINNFNARKTHKSKLALSIGHAVYDPLKPSTLDELISQADQGMYKMKKV
KYRRL
>F5RV88|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei ATCC 49162|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKEPDVLKTYQAKEGELKNIEHKVGQLKDTGATGEELALLYEGLKIVDGLQD
EQQAAIGSVARGEEQQAIALLFGKSYELETERAQSKIDHFRLLLDKRIIADVQAATKTSK
TLRTLSEVMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPSFSQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVMNVAELFAP
NIAPGVSGHLYILERDPWQMRCAAEWLSPEGEKKPFHPDECWAVRRGQSHPPVNGEPDIG
CYHLPESQAQQSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTFRTQMKQAMRNDEPVSCLMIDIDHFKSINDRFGHEA
GDLVIKSVATIIQRAVHDTGLAFRYGGEEFLVLLTGADEEAALAAATEIYNGVHALSLRY
GLSEIGPVDVSTGIASYPQHAQSDNLLRAADVALYRAKELGRARIVSFGRLEAG
>A0A808Y6C9|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. X13|TrEMBL
MDKPLWVRKLRRVSRPGHVVNYCFVAVLFFSTLLIWREVMVLEGAYVTNQRNNLENVADE
LDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHEPIWSVALHNRRTLPV
YGVSDDFVDSQSSLSRNDALTGNELMAVLELGYLLRLVENNRGFNERMLYISRSGFFTST
TLPKNAVQAQTLYTHAIAAPWFTRQSQRNNPGRGVFWQTVLDEHAQNDDPVVTASIPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIASSASGNVLTLLSAREQ
AMLSYAFLHQNQGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGAFGTITIALTLMWL
LFTLMLIISWQVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFERAIATTRMCERTG
RPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQVATAIAERIRIRIYSREILLCNDTSLRISASLGVSSSDDCAGFNFENLQSTADHRL
YLAKQNGRNQVCFNDLPSCAGLRK
>F5RZA0|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei ATCC 49162|TrEMBL
MVSDNQGVCVQHDTFGVKQSFLQWLHKRSNPRLIVNLCFIVVLIFSTLLTWREVVVLEDA
YISSQRNHLATVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRTS
PAWQIAVDKQRTLPINGVSDAFVEKTTLLKRDDEYLDNELSAALEVGYLLRLASSASRNE
ERVIYVSRAGFFLETDMPGNASDIVPRYYRLVTQPWFTHQSERENRARAVRWFIPPPSSF
VGKKPLITASVPVYYQRVWYGVVAMDFTLATLRRLLVEAVNDAPEGEYQLYDNRLTLLAT
SGSPAADVNHFDPRELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVVLRVHTLDEGV
RGDFGSISIVLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGS
LFEQAKRLAKQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLTHAAGLIASTLGAKD
IAGRVGGEEFCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEK
GNYHFENLQSTADARLYEAKQRGRNRVIWQDHVKK
>A0A198GFL2|diguanylate cyclase|EC 2.7.7.65|Enterobacter soli ATCC BAA-2102|TrEMBL
MVLVFSTLLTWREVVVLEGAYISSQRNHLETVATALDRQLQFSVDKLLFFRHSMRDALHV
PLAFGVLQDAVQRFEGLRNIPSWQLAVDKDRTLPINGVSDAFVEKTTLLNRDDDLLNNEL
SAALEVGYLLRLGTSATRKEERIVYVSRAGFYLSTDTTSRTEDIVPRYYQLVTQPWFVLQ
SERENRARGVRWFISSPSTWSNGEKAITASVPIYYDHYWYGVVAMDFALNTMKRLLMDAT
SDHTEGEYQLYDTRLNLIASSEPTAGLINRFDERELAQIAYDIESDTEGGVRLGSRFVSW
ERLDHFDGVVLRVHTLHDGVRGDFGSISIVLALLWALFTAMLLISWLVIRRMVSNMYALQ
HTLQWQAWHDPLTRLNNRGALFERAKKLAKSCAQQSLPFSVIQIDLDHFKSINDRFGHQA
GDRVLSHSAGLIASALRTNDVAGRVGGEEFCVVLPGIALEEAGEIAERIRSRINSKEILV
KKSTTVRVSASLGVSCAQEKGNYDFEQLQSIADARLYRAKQLGRNQVVCDD
>A0A174ZHF9|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MASGFIFSTVDKVTPADKRTSVVVKPEDTRYIGDDTIEYHVKIRASAGNNNALAFVSRHQ
EVEVYAGGRLIYYIKAHRSVYGTTTGTNYTIVNIPPYTTDIIVRLTNVYAGHKIRGTTFE
YGDETKLIKELIAKSLPSAVLSSFIIIVGFAMIVLWIFCRKKIAQTQALFYFGIFAMIIG
AWALNETDIATILVENRKIGSLIGYILLMMMPIPFMQAEKNFFQIGKSALNNILCAIYAA
TAVILLVCHMTGVWEFKNSVYIIHMMLAMSLVYFWTVLIKRVWVKGFDRKVKANIVGAAA
LGISMIVDLIAYYKGMQQTDLIGKLGILIFIIVLGYESISEAFEKIKEGQKVDFYKEMAV
TDTMTGVYNRSAFEEWEQETSDYEGYSIVTFDLNNLKWCNDNLGHAAGDAYIQASARIIK
EIFGRHGKCYRIGGDEFCTVINQKQKSFDIGRHVKQLRELEKYTEEELGIKDLNVQIACG
YAEYDIKTDKNFEDTRSRADKRMYESKRRLKRE
>A0A1F2PJX9|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNDAMYQSILEHAPMGYAYHKIVCDEAGKPCDYEFIEVNPAFEKLTGLFGAKILGKRITE
VLPEIVNDSFDWIRFYGDIALNGGKKEFDQYTAALNIWCRVLAYAPKKGFFITHFIDITK
EKTQLEELNNFFELSLDFLCIADMDGYFVKTNRAWEEVLGYSCEELIRTKYLDFVHPDDV
QVTREVMNRLNEQNPVVNFTNRYRAKDGTYHWIEWSSRPQGKLVYAAARDITDRKKIEQR
LERRMLELTRPAEDTSTIDFSELIDLETIQRLQDQFSEATGVASVITLTDGTPITEPSNF
TRLCRDIIRKTVRGCQNCYKSDAAIGAYSVDGPIIKRCLSGGLWDAGAAITVGGKHVANW
LIGQVRDENIKESQLVAYAREIGADEDDVLRAFREVPRMSIQQFEKIAKLLHTIANQLSN
LAFQNLLQARFINEKRQNEKEILYLSYHDYLTGLYNRRYYEQELARLDKKENLPLTLLLG
DVNGLKLVNDTLGHLMGDELLIKTARIISQVCRKDDIVARLGGDEFIVILPRTAGSVIEM
MIDKIKSLAAAEKVGGLAVSISFGYETKNNEAEDIEEIFKRAEDDMYRHKQYESTAIRPR
PK
>A0A2S1XH07|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. TSH58|TrEMBL
MDSQKDRKATILAATLSSLWTDTEPAVRERVTAIALADADAISDVFYTILLDRPDSNTFL
NHALVQERLRPSLARWISALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDNNHANPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTTRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVSISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKAEQLRRMVEEHRFPGAGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A1C5MA88|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKNHFELKNYVMATGVFILAVVAGILIFFECVQRAVQVNSQNTLKINVQRQSEHLQTIL
DINYQYLKEIASAMGKSEELFSEENKERLVSIYEKTDLERAALIDKNGDAYYDNGVTKNV
SHRRYFQEAISGEQTISDPLESSVDHEVRVVLGVPIYKDHKVIGVLGGSCNVTALSHMLF
NDLFDGAGNSLLATSDGEIIAFDSGSASGTEITYGINLFKYYGEKNLKGKNTLQDIQEDF
KVGERGLVKLSLKERKEEDRYLAYMPLGYNDWMICYAIPVKSAQQAYEFISGYEILFMGS
FCILVLLLLLYIVVRNNQEKAELVRSAQKDALTGVYNRENTQKVIDAILREKAPEGFHGF
LILDMDHFKEVNDVYGHVMGDNVLKMLGGFLKEQFREQDVIGRIGGDEFVILLCNIGSRE
NMESRIKNLHEKLREIRMEGMGEYTFTFSAGIAFAPQDGDTFMELYQKADLALYQVKRSG
RNGYRIYK
>A0A8G0U017|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MDFRVLALSMLLWLVTLNACANSQLDELTEIIYQYPTKAFNQIATLEKQPVTEKASDIDQ
LRLSILKCQNLLQLGENKAAINLAQLGEAKAKRLKLDQARPYFLTCQAEAHLNNNNIQNA
LPLLDSAITLARRYQQPQSLIDSLRLRGQLDTDTDNFSSAIEDLRLAIDIYPDIHSQTQN
WIWPPQAYIYAAMGNLLYATHDFPQAMYYTNLALQSSDAKGKVLHVILRNASRIAFDNQE
FDYSDQLEKQAKALLPEIGSPLELAYSYAILASISLDKGRIDTAEEYISISINSFQKQNQ
LVAVMRSTRLLAQIRFAQSQDEAALTLMQSAIEQGESLKQYSDLKEFYRILSDYYVDKGD
FKQAYDFLLKRHQASEFANEAMNNTRILQFKARINQQDLPQETAPNTQNPNILDELNLDW
AYSTLFLLAMTILGGAIWYFIDKQNNRVPATDNDSQSLSPIQQLESALNSAKQGNYPLAL
LLFNASQIRQVDLPPLQDELQHKLREHDKLIRYSMDEIVIVLPHTSAMGAQRVVNQLTAA
IQPWQGSNRVYIGIAALQQFDTLESLIKRAGINQLGKIKISENSQDNHSPAK
>A0A1C5SN23|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MGLSAIDFLTGILNRRAFQKSVEDEMYKKTPGVFIFIDVDNFKSYNDTYGHNNGDFCLKH
FAETMKKCFPAESIIGRYGGDEFVVYLKNLTVEEVQNYMADFQRMISHLTLPTGEQVQLS
ASAGGAAFPDQGEDFISLCRNADSALYNVKQNGKAAFKMKEK
>A0A1F2Q0X9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MTSFGQDRLQSILPAPRGREKSAVKSAFDLLVQWYRRPDQFDSFNRYLATKGLELAVRLL
VIGSLTTVIVAMTLLRFSDAGVHNHVTSVVNAVIIGVTVAVIVLFCLLPEITRRWSYFFV
AYCEVGVFVGVFLNNDPFIGLIQCVLLILIGGYIAYFHNARLQAIHIALSIVVLAVVGRK
VAVYADPALATALCLIIATGIVVIPFACQFVLSLLGSDADSSDVDPLTGLLNRRGLQRAV
VEMGATGHASSKSSYVVAIVDVDSFKSVNDSRGHEEGDLVLRQIADRLRWCGGEKALFAR
FGGDEFVLVDTIDVGAAPAFEDNLRRHLRIDDRDPAVTTSVGVAITSAEWSSIISDEELT
ELFRVADASMYRAKAAGGDRVVMWDGKE
>A0A853W6M5|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MSLKTKVLLVFCSVFTLLALIFFTVSHVIAGNIAGKLENESIRENVERALQALERELTAL
DKSAADWAIWDDTYSFVENRNREYLEKNLSDSTFEILGFNYALFLNTRGEIVYARGYDPE
AGKEIPLPPGIVFTAHNQTGGLKGVLVTPQGPVLVAARPILKSDGSGPSRGTLIFGRAFR
DKDVKELAEITRLPLSLRPPEAVDFRELKPAGLLKNGEPFYVKILSPEESAGFAVIKDLQ
GERALILQVNSYRRTVQAFLAARRAFGLFLALAAALCCLLALFWLDRTVLSRLARLTAAV
TDIGRSPSSAPGIPLLEGKDELALLSSEISKMLERLEEFQRELGEKEKKYYSLVDNAAET
IIVVQNGMVTFVNQAALAHMGYTAGELLSRSFLDFIHPEDKESALQHYRELLEKKSPLYA
CPFRIYAKDGSVKWVETNSEIIEWEGKPATLHFLTDITPRKILEEELQRLMAEKSLILDS
LTEMVAFLDRDMHVIWANKTASQSVGKSPESLFGAKCHEIWQGKNAPCPGCPVVRSMETG
QVCAGEVTSPDGRFWRITATPVKDKEGKIIGAVEAALDISESKRYEEQLKFLSLHDSLTG
LYNRAFFQEELRRLSGSREYPLTIMVADLDGLKLVNDTLGHAKGDELLQACADVLKTSLR
RSDIIARIGGDEFAAILPKTGEKTGEDLARRIRSTVEAHNKEHPELPLHLSLGAVTSRSA
AESLEETFKKADDLMYRNKLLNRASARNQIVGHLLAALKEKNYITAGHAERLQELCLKTG
EKLGLSPQQMADLALLVQTSDGQIPE
>W7WZ24|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MTSDFTIHLPTLMLLAVVVMGATAAIMSVFGLSQRVYRGYWWWVGAMWLATLGAALHGLR
NLWPVAVVPACLLVMVWPVLITTGLRRFFSRDRQFSSTRIDVALYVACYLGWLACWLASA
PQPIRSLAYGAGSLILLLYAAVFIGKLDDFRRSPALKLLMAVMIVQAAVPMLRLAGMFSQ
GAGALPAQSLVVTGVVLPLLLSMLFTVYLCLVLTHERTVRDLRETQRQLRVLADIDMLTQ
VPNRRHFEELATAIVGNGAAPPSVLMLFDIDHFKHVNDNHGHAVGDAALRLVARCTRDTL
RTRDVMGRVGGDEFMLLLPGASVDDALHVADRITRNLDLASKNFPLPLSLSFGLVQIQTG
ESLAAAQHRADLALYEAKRQGRRRAVPARQDGPDTVFGESRSLGLDPL
>A0A1S8QCT8|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MEPVNVRKKVDILITILIAYFFVLCLSYKVFELDNSFENYIMLEVVMIIALVSYYTNVTL
ALVVTLTADFIYMSYKLYLNFWGNVNIDFYSYYWIFLIPSTAILMSLVSRNIFALQTENE
SLINENSELVMIDEETNIKNQRALLMELPIYMKLSTRHKIPVTLLIVKIKFAEKLRSILG
KEGYKLLLIQASQVLEKSLREEDIKYIIDDKTFGFLTITDMSGAKVVKERFRENINKYDF
TKGSHYKKVKLDIQIGSYTFDNSIKDPLELIRLAEKELEYDIHE
>A0A7Y9D4G8|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MVLEFFQNACILIAFMSIAQHLLRNKRIFEDMSLKSKFLWGLYSGILGVILMINSVHITP
DAFIDFRYIPILFSAIYSGFFSSIIASILIAIFRSLILGVSDISLIGSAIALAMGIGFGI
ISLLKISKKRKYIYSMIFFVIASVISSFTVPQNVKFVFQAVSLYFSGYLIVSYISIKYAD
YIFETVRIYQKLRNEATKDYLTGLNNVREFDNSFNNISQRAVRKEEELSMLFIDIDFFKK
INDTYGHNAGDTILKSLALILLDTCRAYDVVSRMGGEEFSIILLDCSDSKAVKIAERLRE
KVEDNDFYISDNKFIKITISIGIASYPNMTTQVDNLLEMADTALYQAKNTGRNKVVLFNN
EEHKI
>A0A1S8S6Z1|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKYGIILDRLVNFKLVKKRDELKLRNVNNKYLIEHEIVIEENFSNYIVTDIERDARYVL
CILKNGFTYEKTREYLLSKFKTIKNLNFENVTNIINIEIIYSINGIKLDTPQYGYLMEYV
EDKLDTQNYFNKCNFHKKLDTFMEICATINTLNMQGYIYDDISIKDVILIPDSNNNVKVK
MKDLLANELRKFNLINSLPYQYNIETREDINSNKDNVVQVVELCRQIFTESELETGFKGL
EDIKNIYNRVNTINKSFKLKYFIQNINKKMKKNYRLFISEALNKIKTDLDIIGMTEEIKI
VEKNFQSILENKQRNKFINFNGEDGSGKTRLLEEIKYRFENKYFKDIIYIDDFNNKNASD
EEKYNTILNYILNKIDKNLRDKYEIYIKKFISILFEKNSINGENNKQKLQLINRMGKFIS
EYTMTKPFIMIIDDLDKKNEVFKLFIKYIIFLRNNLENVMIIFSMNESSIDENFMKFINE
LKQVEKYEEYKINYFNQYNTTKMIRGMLNTGTDVNKLAVKIYSETLGNPQYISGVINELY
DNGTLYFDSDNGEWKTNIKVQDILIPKSLERRLEASIFSLNEKEISILKELAIFKTPLSE
KIILEYVIMDSNNVEIYKNLKSKGLLTDKISDQGILIGFRNNLLRNILYLKLSEEERSKL
HSKASIFMEKILLETDYYIEELLLHLEKSNSYEKAYFYTLKYAEAQDLLGDISKSISYYK
KVLTYPSDSSGSEVAIKIAKLYEKKSNHEKSFEYFEKANQIAIQNDEIEIEIYTLLEMII
IKINSITDIDTGIDYSLNCVRRLLDKEHYPKGEVYYYYALSLKYRLEYNNKLTLLNAQKA
IIICEENKIKEDVYGWAVSILISIYIKKGNYKEAKNLCLYANGIFINNNNINGQLYIKLL
DASISKEEGKDNKEILEQYLEIAREGNKQKVYKREILSLICIADIYSQEKRYSEAEKYLL
RALEREREEGIDSYSFNICNELCLLYIKSGRISLVVKYHNLIMQMQKGLKLLEDRIINTN
YTYALYNLMICNYDLAYDHLKKIYALIFNSNSSKYKIVVCNYFELILYKCKNESDIRNVY
NRLEKKINLLQDVDTCLEIRISAIRRILTLGYKVLAKELFLDLKGYPKNYNVEGIYVYLE
LNFRNRNQYNFLINKALRVCSFVDNEEIKADIYSAIGEKYNELECNALALNYYYESIALY
IDTINLLPQNDKLSYANNSRFLETRKLFVKCLNVDLGINMSFKSTQFIKTIEDLEQILKE
LDLMNILDNEDTFKLVQYLYEKCYYNDFRDIYKVFEKFSNNTIDDIKNVMKYMARLILAD
KAMIVTENEQGENDVICTYRISDKNEINRYLSLKVDSDEDTFAICSNDSRFYQLDDKVLK
DGIRSCMYMKIINREKHINSSAGINARLIFITNNALNYINNESKKTIEKFKPFLTFLLEK
YNLTISSTLDKLTGVYNRKYFEEALLFLLDSARARESEFAVMMFDIDDFKGVNDKYGHQT
GDEVLVKVANEVKKCMSKGDIIGRYGGEEFIILLPNVNYEVAISLGERIRKNIEEARILG
DKRKITVSIGIAMSSYESLNNEEIIRRADQALYKAKRDGKNRCIVWENECGASGNTNDEL
TGVLSGNAAKDYNFMLMLKEIAGITKRRCSKEEKIYNLILKIMQTIECDIATIFIVKEKK
IVNTYSKRRNKDNWNLDDRFNFKLVNQVIEEEKGLYLVDWESMDSHNSYGLPDWKSVCIA
PIICNGELLAVIYLSISVNEKEFICNDYNVLNFLIEIGSSIFLG
>A0A3S4IKK6|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MTAQTWRALLKAKHQLSLRLFLLLNALAAAFSMLFSLHSVLRLTPPVIAILLASLTLLAW
QIRDKKRLINLNIASFFFGLLWALHIFLKNEAIGHPDTSFLVISLMSVLFIGAISFINNI
VPFLLQSLPVALVVLWLGDVDQWLRVLYSIALPAIGITIQHIIQKRNDWFTQRLMNQLLE
EKETLSDLSMLDPLTGLYNRRGFQNRLEHIQASGPGSHYVLLLDIDYFKSYNDHYGHAMG
DQALIRVSAAIRDAVRSRDIVTRYGGEEFMVMLTNIDAERALQSAERIRQRVFDLDIPHM
FKNQATTNVTVSIGMAPFSEGSIDDALRLADKALYQAKHRGRNSILTHEMVTVN
>A0A377Q480|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MPAQKIISQWRILQPIHFVLGLLILLTVSLLLWQHYGMNLFLRFDPGNFNQISASDDRDN
EGGKSIGLISINPKYWRLDCQLQKGHRSPYCSIDFDLSKGKQGIDLSKYTDITIRYRYQN
PREQVNLVMVNFNPEYSVESDYRSQKFTEVYLPGVMGWSTYTLKWQQFNVASWWIADKKI
PPKWTDNEFNNIREIRLATGLYPELSNHQIDLAYIEFRGKWINNNTLQLLLLLLWGGTAA
FWLLSELRRSMLALQRSHARQKDLENAQQHLQETNQLLAERSMRDPLTLAFNREGLSILL
AKETPDTPGSIIFIDIDHFKKINDHYGHGTGDQVLCLLVQHIQQQIRPSEQLIRLGGEEF
VLLCQHSNLAQAERLAEKLRLWLFSQSWPADIPLSCSFGVAERQKGERFEATLHRADLAL
YRAKAGGRNRVEVAE
>U2EJN3|diguanylate cyclase|EC 2.7.7.65|Salinisphaera shabanensis E1L3A|TrEMBL
MIDLELLQHAVMDSRDGIAIADARAEDLPLIFVNPAFERMTGYSHDEVLGRNCRFLQNGR
IDPESRAEMRAALRKGQGFSKVVTNYRKDDTPFWNELSISPIHTERGAVTHFIGFQKDVT
QRLLVDEELRARNRDLESAKKALEELVTLDALTGVYNRRHFDDRMESLWKISSRTGESMA
IFFIDIDYFKTFNDHFGHQAGDEALIQVAQTLAESFQRGSDFLARYGGEEFVVVACGMDQ
EPARYFAERLCERVRELDFDNPDTESGRLTISVGYTVVTPHGGLNAQTVIERADQALFEA
KKAGRDRACEATGSTHGWAPARRSYEVSRRSNS
>A0A7R6W5L9|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MSQPNSELSKWKDKYYNALDDLEALELVSQTSNSLFCRALIRLSLAVKGFNQQLDPHLLR
LRNQLKQGLANAELKQELESFSEALLRFEDGSAIEPLQDAALLFDFLTNQEQSPQKVSAI
NLLRGQYDTGKLAGSKELLELVSELYAVETIELDDGGDLVGIAANLDAKFICEQLSQLIQ
GLDVPDISQARTKKILQALQAEQIEATFQENIDAALSLLQDLKEHNQFEKKEMEVFLAHI
NQQLAALSKSAKGVVGSTGKIIRKRNNLDQTVSKQMQSLQENSATATKLEPLKSLIKSEL
DDIEAQIKQHQQEEQQQQASVEKQLAAMTTEMETMKAEALSLKENLKRASAEAMTDALTQ
LPNRNAYDSHFSAEYARWHRYQTPLSLLVWDIDLFKKINDNYGHKAGDKTLIIIARLLEK
YCRETDFVSRFGGEEFTMLLSDTDKKSAWVLAEKVRKIIAKTGFNSAGKAIGITISCGIA
ELQQGDTQETVFERADKALYQAKKNGRNQCVIA
>A0A377SWE3|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MIDKIILFIPWALALLMFGLWLRSERIRRMQKIKLTELIGKDPLTGLSSRRHFLDIAARE
INRSQRFSNPLSALIIDVDDLRNLNKTYGQIGGDLALQHIAQACRQSVRDFDLIARFSGE
EIALLLPDTPLDGAIVVAERIRRKAEEKRIMMPDGLEFAMTVCIGVAQTQTEMDSTEDLL
LAADTALQKAMTTGPNKVMY
>Q8EEE8|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MKLVLQLIVILCCVLSNSTVNASQGQTESLIVVMGEDSFPYQFVDNDGEATGLLVDLWKE
WGKRTHTPLVFVARHWNESLAQLQQGKAQVHIGMGKTPEREQRFDFADAIANVSTYLYLH
KSLQGKKNIKELIPYQVGIVSGSSHEAELRRLEPGLVFKYYQSRETLLAGVAAGETVVFA
GLDGYLRDPASNQTIAVNYPLNIRIPIKAMQFVPAVMKGNTELLNKIKAGFNGFDPKFIQ
QTERRWLGFNGQKPGIVVAMQLGVEPFVDLGVDGLPHGFYVDLWRLWSAKTGIDINFISG
DMNGTVNDVRQGLADAHIGYPESDDMKTGLTRAWQLYTVKSRLFLYQQQLTDLLSLKGKR
IGVVPTAPYLVSLRKALPDVAFRYYDNMDAMVAAARAGEIIGFVAAGAWTSHYLLQNKAW
ADFHQYPELEFPTEIYVLTRSDDPGLTQRITNGFRSISMQEFADVEQKWMLNPKDRIFNQ
AGLHGIQLSASEQEYLASIERIKLGYLKQWLPMEFTNEQGQFAGINSDIINMLSEQLGLK
IQPIAFDDWQSLIGALRAGDIALAGSIAQTADRQRHIVFSDPYWPSPWGVVSQLEQVSVF
NLAQLAGQRVAVVEGYHLVTQLMTLQPSLKLVLVPNTQSGLLAVTEGKADVFIDKVVTLA
SELKTGQYSLLKMSLLSDLADQHSHFGLNPQFSSLAPLINRVLAQIDQQKQQQIYSHWVS
FTIATDDGQYLRWIRYLLFGALGLSLFMVVVLVVNRRLKREITRRIAAEKRLQHVASHDV
LTQLPNRGLLDDRLSQALLSHRRDQSHFALLFIDLDGFKQVNDQHGHPIGDALLLRVAGL
LTQAIRHSDTVARFGGDEFVILLNRVQDLDAATQVADNILHSLSSPFTIEGVTVEIAVSI
GVVIYPRDGDTAIELLKKADQLMYQAKTVGGRCYRVA
>Q8EIP1|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MINIAQMALVLHSLPDPAFVITQSGRYVAVFGGKDDRYYHDGSGLVGLYISDVLSENKAA
YFLSIIEKALNSRNLLIEEYELSNKDVKGLPDQGPTEPIWFEGRIQALDFLVDNEPVVLW
VASNISKRHDLEVQLRQLSDTDQLTGLYNRHRLERDLNYLFDTYCRHHIPASILMLDLDH
LKLINDQLGHHAGDNIIMTVANTCKQQFRKTDSAYRFGGDEFVIALPGVEYTQAIVFAEF
LCDCCFKELQKHAVKGLYATVSIGVATIQANDKSYEDTLKRADAALYQAKRDGKNRVIAN
TA
>F4T0W6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M605|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5B0T0P8|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVEMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGSAE
GEVIEEQAFRAGLVDPALSKALDRRVFSEFFQNSAQAVASKGLSIALPLSAVGLLNTELI
DELLEHLQRSPLPPRLLHLTIPASVFKTNPTQAISALHRLRQYGCRIILSQVGRDLELFD
NLKYRIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGVDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A0T9NK72|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPAPETPAVTLPILMITFISLSAVGY
LVFISKNYADKLNLFSITLGVLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPPALTVIFLDDFQNIFRIIFTVMLPLIGFSLHHLMLRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAVAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYATQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLASSLKAADEALYRAKKDGRNKVAFAKDELSKFESSP
>A0A6G7TGF1|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 29361|TrEMBL
MCVQPDDIVRKEVFAAPHRFHPGRVVNICFITVLIFSTLLTWREAVVLEDAYAATQHTHL
ENVVNSLDRQLQFSVEKLLFFRNGMQDALETPLASTVLHDTVSRVSDLRTKSFWQLTFDE
RRTLPLNGVSDAFVEQTNSLIRDDERLEQEMSAAFEMGYLLRINAPPAHAKRIVYVSRAG
FYISTEPNNGERDITTRYYQLAITPWFTRQSERDNRARSVRWFTQAAERDRIVTVSVPVD
YQRYWYGVLAIDFTLQGIKKLLQDAVDGNGEGEFQLYDNSFTLLATSESVARNASQFDER
ERAQIASAMEKDTEGEIRLGSRYVNWQHLDHFDGVLLRIHTFREGAQGDFGSITIALTLL
WLLFTGMLVVSWFVIRRMVSNMYRLQHSLQWQAWHDPLTRINNRGALFERAKALAKRCEQ
QQQPFSVMQMDLDHFKNINDRYGHQAGDKVLTHAARLITSTIREADVAGRVGGEEFCVVL
PGAGPEEAMQIAERIRARINGREILVKKSQTARISVSIGVSSARENGNYDFEQLQSIADA
RLYQAKQRGRNQVVGQEEKK
>A0A1K2G1E5|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. F-1|TrEMBL
MNDLLTMVSAAGPLAGGWGVHWLWMRRRLSAARRDPLSGLWTRAPFERRAARLVARRPHA
AVVLVDLDGFKALNDTFGHAAGDEAIRATAASLNDALAEKRGAVAARLGGDEFAAVVPLE
EPFTLPWLLNALHGAFTAPFTYRGRTIRVGASIGACLTAELSSRSLPLALRRADEAMYTA
KRDGGGWCVADGPDLTHSSRTGRRAGRPGTSGKEAA
>A0A178WV80|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MIALVALHRGLLLTQFQRDARTDVTTGLATKRWWRTVAERYLERARANQDSVGVLLLDLD
HFKAINDTYGHPTGDLVLREIALSLRDEVREQDVCGRWGGEEFAIALPDIPSAEHLGHIA
DRIRRRIPQVIVTLPGQDSVISDLTVSIGCALYPAEHLTSVDDVLVAADAALYRAKQAGR
NRVELASA
>A0A8B3UDG8|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MMNDETYYNTKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWAFVWPHFAWQLSCRAASPHQQEEFNLKIDAIIAGLWIGVMGMSALPTA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPLVGRVAVFNPDLVEWSLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVYNRRHWEMLLRNEFEHCRRDRCTATI
LLIDIDHFKNINDTWGHAVGDEAIIAITRQLQMSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHERLETLSLPCAPKEALRISVGVAPWGPQFAHYREWLKAADVALYRAKNAGR
SRTEVAA
>A0A156K0W1|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MLANSRCLKGRYISFCFGCLVVIGILQALFSKVVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLIAIAFAFAGSALLMVGTLSSFPAWLNLYQFNVVNYNDAMIYFMF
RHFLMAVLFIVAAILYPTRDYSFSRLAHLSIVSGAFLFTACVVGLAWIYSSHSPFLSIDL
VDNETRQFMVLWSQCINISLIVFWVVSLVTLMFVTRVRNLFWVGGNFLCVCYIVTLAMLL
VGGHAEDISWYRARLFETVATLMIIFVLLYDVFMLYRDSHLKYQQSYQNSIRDPLTRLYN
RSYFYESLNQALDMAKPSRPVSVIVSDLDRFKRINDNYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLANTSSDAAHQVAERIRLKLSSFDKTSSGGQLPEPITISMGVFTA
TSSSVTAEACVESADKAMYEAKETGRNRVVVFK
>A0A608MUY5|diguanylate cyclase|EC 2.7.7.65|Salmonella thompson|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1E2RX39|diguanylate cyclase|EC 2.7.7.65|Methyloligella halotolerans|TrEMBL
MFDSFTTRLVVEAACLMGSLTIFSFWLKDRHTSAHLWWIAGFGLFGLGLILGSLRQHLPA
LLSYPVPGLLTLLGVSAFWAGLRAFDRRPFPLLALLPPAIWGLGLPLVLSSYPLRYALFN
LAIGTATLLTGTDVWRQAPKGINPRTCIGFICLLETAISYTQAVALIAMQEVIGDGPLFG
WLTFAPFQSAVALIALVIFGIQLISERSQQRLQRLAMSDELTNVLNRRGFFELGQQALRG
QSDNAGDSSVIVFDIDRFKSINDTYGHAAGDQVIATFAKRAARLLRPDDIFGRIGGEEFA
LLLPGTPSDVAASVAERIRLAISEEPITGEGYTVSVTTSAGLTSAPNSHAHLDRLMATAD
AALYEAKRLGRNRIKSLDSLPSGLRHLTPIARVPHKA
>W5SDI3|diguanylate cyclase|EC 2.7.7.65|Borrelia miyamotoi FR64b|TrEMBL
MIKGMILDNFEEISNEPQKLLLVDDTPTNLDLLISILQHDYEIRVALNGFDALKQVEIAS
PDLILLDVLLPDMSGYEVCKRLKNDPETRDIPVIFISSRASIEAQLEGFNVGGVDYILKP
FNSRIINARIKTHLELKRLRDYFKNLARIDGLTQIPNRRFFTDKFAKAWMQALEHKRHVI
VGMLDIDYFKKYNDNYGHTNGDECLKLIAKSLNKIALRYKIDIARYGGEEFILFCVDKSL
EEMIEIVSLIIEDIRSLKIVHQYSSISNFVTVSIGLAEQIPHDVNFTNIIKLADDKLYEA
KISGRNQFKY
>A0A7I0E2B7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFITVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A2J9E9Y3|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. FDAARGOS_194|TrEMBL
MAALPLSIRKLRPELRVHLLFLAVFLFSFFLTWRELHTLKINYEDRQRAALADMQNGLES
QFQESIDGMIYYRRMFTYALAHPLDAHHARRALAEFQQLRAQPAWQLRLNMPRSMPINGV
GDSGLAQDALLQRDPARLDGEVLAALEFSFIMQFSDAEADFHSRFWYTSRAGFFITSRPP
QSLSALAANYATMVSRPWFRAMATLASPQELRWSAVYQGGEDEGAMLTVSTPIFINGYWY
GALSMDFTQQRIASQLSNMHHSALQGSVVLLDKAQQLVASLNASDAKPLSDGAQRQLYAQ
IARQPQGTLRLEHQFISWSRLKNVDGYLVNQQILAQGLRQDLGRAMLFMLVMWLLFVLLL
LLAHQIIVRLVRRLSQLSDRLAWRASYDGLTRLLNRSAFFERFEAEATRCRALNAPLAVI
QLDIDHFKAVNDTWGHQAGDQALMRVAAIVSQALRKNDLAGRVGGEEFCVVLPETGLADA
EKVAERMRERLAAKTILVNASHCFSVTLSAGVASSEEQGDYQTTSLQAEADRRLYLAKSQ
GRNRVVAGG
>A0A6N3J1G7|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. (strain W3-18-1)|TrEMBL
MPTIGTEKYTAEWLALVNNLSRSDAGQLEHLIHQNQHALSDTFYQAMMQDSSASEFLSND
LVQKRLKASMQQWLTDMFQSQTTEHIQALVAQQIKIGEIHARIGVPVHLVLNGARYLKTR
ITQLTSHALASHASILIDLAMEIMSQAYSNSHERNSRSEEAYRLHAIAQNIAHEKDKQRA
AFLDWENKVMFDCASGVDAALLQPLYSSEFGLWFRHKAEHAFAGAEEITLINDGINHIDN
VLLPLLALPSLQADTKKLQCLRELREQSKSIRYYLDLLFEQNREVESGRDVLTRLLNRKF
LPAVMTKEVSYSRRNKSQFAILAIDIDHFKTVNDSYGHEGGDLVLQHLAALLSNTGRGGD
YLFRLGGEEFLMLLVDINAREAALSAENIRRKVERETFLLPHNQQLQITVSIGLAMYDGH
PDYQRCLRAADDALFAAKRAGRNCIITAIDKADS
>A0A7S8W8K5|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKSLWGRKLRRLSSPGHVVNFCFVVVLFFSTLLIWREIMVLEEAYVDNQHNNLENVAHE
MDGLLQFNTDRMIFFRNGMQSALETPLDFMILRKAEQEYISKRHEAIWSVALHNRRTLPV
YGVSDAFIDKDPTLSRDNTLSGNELMATLELGYLLRLTNNNRGFTERMLYVSRSGFFVST
EALTNTTQALALYSAATRSPWFTRQAQRTNPGRGVVWQTFPEEGALRDAQVVTASVPLDF
RHYWHGVLAMDFSVREMKTFLVNAAKGGQDGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
ETLSYAFSHDNKGGIRLLTRYISWEKLNNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGLFERAIAAAGECERGK
RPFAVIQLDLDFFKRVNDLHGHQSGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPN
TTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVSSSEDCAEVNFENLQSIADRRL
YLAKQSGRNRVCSTG
>A0A3P8KKF8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTAQSWRAHYEKKYQYSLRLFLVLNLISAFLSLASPLFTVVSFTLPCTLIFACSAGLLLW
HWKFAQRRINISFISLIFGLLWAWHVCEKSSMMPPPHFNFLVIALLSVLFIGAIAFSNNI
IAFTLHSFPTFVACLILAEGEQWLRMLYCFVLPIVGITMQNLIQKRSDTFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGNSHHVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTNSTAETAQQAAERIRQRVYDLKIAHM
FNESVATNVTISIGLTPLVDADIDGALKRADSALYEAKNLGRNIILAS
>A0A2U1TY18|diguanylate cyclase|EC 2.7.7.65|Brenneria roseae subsp. americana|TrEMBL
MNELLDSNKRIENNEVIYNQVITSEWKELLAITSPEAFNLLQRLADEKSADLAEAFYSYM
LQDKEAAFFLSHQQVHDRLHGSMCNWVTSILSNVGEDLPALIEHQKKIGQIHARIGIPVE
LVERGARRLKWTLYEDILPETGNDPLCFEAMRFASISIDIAIEIMSRAYSQSHDRAAKNE
ESYRLFSILENAGMERERQNAALLNWENAFIFSVATGAPLASIPELSGSEFGLWFNHKGK
SSFNNAQGIKVISDLIVETDNYINHYSKVSPLSPSNYSPFLKSVRGKIYKINMLLGSLFD
DVQKLESGKDTLTLLLNRRFLPTILRHETALAMHANSALTVTMIDIDHFKSINDTYGHAT
GDIVLKKIAEILYENTRNSDYIFRYGGEEFMVVLIETPKLAAYALIDRLRKKIQDHQIHL
QNGKTITTTISAGIAVYNGHPDYEYLIKSADDALYKAKANGRNRVEYASEDDLQKN
>A0A5I8VHX0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stockholm|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V5J4B4|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA052|TrEMBL
MAGSKDGAARALDAVSRIVREARMEQDADGARRAVARLTAECMGYRAAALGIIDSDGLLK
FTVFGEAPNCQEARACREAPTRAPDGSWISAPLAGIGRFIGTLIGYGHGTGTFDAEDLRI
HARLCDSVAVILEAQMARANLVETMDRDAVTGLYNRKHLVKRIHEEISRAERYGGRFALV
FLDIVGMNDINASFGYGMGDAVIEAVASALRSSFRGSDVAARFGDDTFAVLLPGADKPQG
QIVANRISRVAAGNPVASDGVRMQGPDMEWCVVSYPTDGSTCDALLAARNMGP
>A0A653RI09|diguanylate cyclase|EC 2.7.7.65|Pantoea brenneri|TrEMBL
MEIGGISAWYFEAAQVKRALLTGIGLVQDKIGRLNSEAQTDPLTQLLNRRGLNAVLDYYQ
TLRQPFSVLALDIDHFKNVNDSWGHDVGDRVIQQVASTLRASARQSDVVCRNGGEEFLML
LPGTPLEEALIIAERVRLGIAEAWLTDVGRITLSIGVSAWNGQQDVSLEASLKQADAALY
QAKNSGRNCVIAAPVS
>A0A845SIL5|diguanylate cyclase|EC 2.7.7.65|Acerihabitans arboris|TrEMBL
MKLNGQYYDALIMKEWHDLIAITSDAAHNILISLLDEDIDLLVDDFYDSMLGDDDARLFL
SSQQVKDRLHGTLAQWIRGVLSSSTADLPALVAVQRKVGDVHARIGIPIDLVARGARRVK
ISLYTRLRRDITDLTLCYDAMRFSSLVMDMAIEVMTTAYSRSHENSTKDKENYRLLSILD
NVHVERERQLAAVLNWENRFIYNVATGLPLAEIAPLAEAEFGLWFQHKGRYVFESVDQVA
AIEALLTGADAFIASYSAEKVAVVEERYILLRTVRSQVQKIGTLLAGLFDELAKFENGKD
PLTNLLNRRFIPTILRREIALAMRSGTPFVMAMLDIDYFKSINDRFGHDAGDAALKDIAA
ILHESVRSSDYVFRYGGEEFMLLFVEASESQAIAIINSIRDRLENRPLHPSGGGKVSLTV
SVGLCLFDGHPDYERLIKKADSALYLAKRNGRNRTETYRDGQPAAAGDEV
>A0A1S8MG29|diguanylate cyclase|EC 2.7.7.65|Clostridium roseum|TrEMBL
MLYEKYEKLKNEFSTYQNFAEAQIQRMNGKNTELEKKLDILTNIIEVSKYINSNISADNL
IPMINDMIIGILGVTYSTIYLVENNEKLIVKASNVMENYNVIVNPAFSTFSDNRPVVINS
KKPLFKEFKNKLEVHSIIGVPITLRDNFRGYIIVEHTLYDFFSHGHIKFISSIANQIAIA
IENSFLYNKVKESSIKDPLLGIYNRKHFFDMIEEKVAKDSRKSFAIVMIDIDHFKNFNDS
YGHQFGDEVLIQTAKVLENNISNNDEVARYGGEEIVIYLDNAENTEEVFKLVDEIRFKLS
NNLVKHGGIEKSVTASFGISYYPQNGESVEKVMSVADAMLYEAKDTGRNKVVSSL
>A0A2H6AX07|diguanylate cyclase|EC 2.7.7.65|bacterium HR39|TrEMBL
MEDGDGSRPDLAYRFPLPEVGDADIPDRGIRRPRVFRRPPARPDASTPRTASQPMQPCGP
PQRAQPAGLRRSIRMVRVRSGTDRTSRERLAREAAMVRGSETLHGMFDGSGRALARNGAM
RDALGAASGHFLDMFEEEDERRRAAAALRGGSAYRGLGRLRVRAGGPWYRIVGNWRTDPV
SGEPALFVEAVPVNELREEAAHYRHLAETDALTGLLSRRAVLERLQELCGDRRARPLSVI
LADLDHFKRVNDRFGHAAGDRVLTAFARILREALRGDDLCGRLGGEEFLLVLPRTGPEAA
AGVARRICGWLRTHLAAAADIPGDPLTASFGVSAFAAGDGDPRAALERADRALYRAKAAG
RGRVEVEAAGPTRR
>A0A1A8XNQ7|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MTNAVVIAVAGSDRKVWRPALKALLDRSLPVVALLCLAIFSTSVSADATSPQKVLVLHSY
HQGYLWTDMIQDGFSRTLLEQLPGTEVYVEYMNTKRQAAEVMFPHLVKIYRQLYENVKLD
AIVASDNNALDFLLQYRDTLFPGVPVVFCGINNFLSYQFYPGSNYTGVREDLDIVSTINI
ALRLHPGTSKIALITDSTETGQINLGLARDVAHNFPAIAFIELNDLTALQLSDSLKQLSD
DTVVLALAFFRDSAGRNFSARESMDFIVSASPRPVYTVWDFYMAPGAIGGKLLSGRLQGE
SAAVLTGRILRGEKADSLPVVESPTGYIFDYAGLDRFGISESLLPVGSIVTGRPDTFYSR
YKYYLWFGAALFTAQLILIISLFWNIARRRRGEAARQCAVNALSETNRMFSQFLLHSPVH
VFINEIKPAGSHVLMVSDNFRDMVGIADSEIIGKTMRELFPAEFADKMDAADLSVVSTGK
PLGAEEHFNGRSFTSIRFPLIQGDRKLVAGYYIDITERKEQEEKNRRIMAENETILNNVL
VGIVYLKQRRIVSCNRRFEEIFQYLPGELLGESSLRLYDSRETFEQVGVEAYATVAERKN
FTAETRLRHKDGSLFWGALSGRAIDPSRPQEGSIWIFSDVSERKRAEMALYERERYQRAL
FDNFPFLVWLKDRDSRFLAVNQAFAEACGQASANLLVGKTDLDVWPQELAEAYRADDRMV
LESGRARSVEEHIEVDGQWVWFETYKSPITVDGRVTGTVGFSRDITERKRAQEKLQLAAS
VFTHAREGIMITATDGTIIDVNDTFSAITGFSREEVLGQNTRILSSGRQEKAFYALLWRD
LTETGHWNGEIWNRRKNGEVYAEMLTISAVRDSRGKTQQYVALFSDITALKEHALQLEHL
VHYDGLTTLPNRTLLADRLQQAMAQAQRRRQPLAVAYIDLDGFKAINDRHGHDAGDQLLI
TLASRMKQSLREGDTLARLGGDEFVAVLLDLAVVETSTRLLARLLQAAAEPVLVDDHVLQ
VSASLGITFYPQMGEVDADLLLRQADFAMYQAKLAGKNCYHVFDAEQDHSVRGRHESLDH
IRRALSEREFVLYYQPKVNMRTGRVIGVEALIRWQHPEKGLLLPAVFLPVIEDHALAVDV
GEWVIDTALTQIERWREAGLDIPVSVNVGARQLQQPNFVKRLRAILAAHPDVSPGDLELE
VLETSALVDLARVSGIIEACREIGVMFALDDFGTGYSSLTYLKHLPVKLLKIDQSFVRDM
LDNPDDLAILAGVLGLAVAFRRQVIAEGVETVEHGKMLLQLGCELAQGYGIARPMPALDI
QGWASAWRPDCAWSNRSAINRDDLPLLFAGAEHRAWIVSIARYLKGKRVNPMPLDHYLCR
FGAWLDAEGQTRYGQHCAFQGMLSLHRQVHALAGDLCELRSMGRNLEALARLCELDSLRD
ALIEQLQALLESRQ
>A0A1R4LUM5|diguanylate cyclase|EC 2.7.7.65|Vibrio ruber DSM 16370|TrEMBL
MRDILFKKWTVIGFLVLLACILIVLVEFIFQRHQEVMRQEIQSRTTEELSIIRFKLEATI
LADIYVAKSLSTLTTVNASTVAESWEKVSQRIMEQGKYIRSLSLAPNDIVEYVYPQEEHH
NVVGLDFRTLPEQWATVKQAHELKEIFIAGPVERGEGDHVIIARCPVFLDPPYNQFYWGV
ISVDIDIDSLLQSLEVDKVLPGYDIAIRGQDSSGEQGAVFWGQPDVFKHAFAKEMIYFPH
GSWSIAIAEQENVNILDQVPWFQTNIVRVIGYLLLVCLVASFLVIYRLYDKSNRLSLYDE
LTHLPNRRYFMNELNRYFEREKRAKQPMGFALLCIDVNKFKTINDTHGHSVGDQVLVECA
RRIENAIRDNDCAARIGGDEFLVLLKGGEKGEDLRKIMDRVRHAVGVTPVICGELAIPVG
ISVGYTRYRPDMQSVNEMIHHADNEMYDEKYAS
>G6F8T6|diguanylate cyclase|EC 2.7.7.65|Lactobacillus delbrueckii subsp. bulgaricus CNCM I-1519|TrEMBL
MQLLEDGVPVKERGKTRSRGQIREIMILKAPVYDQDQIVGLIGFFMDITNTSKQINRLEN
EAARDDLTSLKNRHNFARDFNYLTGKPILAMMLDVDHFKKFNDNFGHRYGDEVLKKISQA
LLKIYGIGHCYRYGGTNSWCSATLLILTRLRKKTGSSGKNWNMPGSWIFT
>A0A4R0GZC2|diguanylate cyclase|EC 2.7.7.65|Kosakonia quasisacchari|TrEMBL
MRQNRVVKQPRSFKQLQRYFVPAQVVNLCFVIVMVCSTILTWREVIVLQGAYVASQRSAL
ENVSNALDMQIQVGVDRLLFFRNGMQAALQKPLGFEALNSVQGEFDRKRTLPYWQIGLDN
SRTLPIYGVSDSLVEQSGLLRRDEERLHNELTAAMELGYLFRLSYEASMLPRQAYYFSRA
GFFLSTRAVEREQDIISTYYRLLTRPWFSGQQQQENRARGVRWFTLLTNPETNSFVAASV
PLDYEHYWYGVLVMSFPVSAIKPLLVGEQLQQDGGEYQLYDNHFRLLTSTQPLQNASGEF
NQDEVAKLQADMARDTVGGLHLGTRYVSWQKLKHFGGALLRVHSLREGLSGDFGRISIAL
SLLWVLFTGMLLFSWVVIRRMVNNLYSMQHTLQWQAWFDPLTRLYNRGSFFEQAKLLSEQ
ARVKQRPFSIIQLDIDHFKGVNDQFGHQAGDLVLSHAAGLISSTIREQDVAGRVGGEEFC
ILLPDSTLEQAAQVAEHIRSRIESKEILIHKRTTLRITVSLGVSDAQESGNYDFEYLQSI
ADSRLYLAKNNGRNQVCSVDEMPKR
>A0A7Z9BXZ6|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MSPSPSFQENQRLQTLYRYNVLDTASEAAFDRITLLASRLLGVPISLVSLVDQDRIWFKS
RQGLDCPTVDREGSFCGFAMYNQGVYCINDTLIDPQWCDHPLVKGEFGLRFYAAAPLCTS
DGQRLGTLCVMDHHPHELSELEVQTLQSLGELVIEQLDLRLASQRLQETEIALMQSESRF
RALVEQAADGFLLHDFNGQILDVNEFACQSLGYTRKELLRLSIQQIETEPIPMILFQSLV
PGQPIAIQRIYRRQDQTTFPVEVRLGLIQVGGQQLIHTLARDISERLEIEQQLKQQAERE
RLNTRLTQRIHESLELSQILNTTVTEVRQALKNERVIIFRFESDQEGEVLTESHAQECFS
LLGNRYKDGCIQETLSLEKTDKVKSVADIYTGDISRCHQELLIKLQIRAYLVTPIWHGQK
MWGLLVAHQCSNPRKWQVWEQELLVSLAAQLAIAIQQSELYHQLKIVNHELRDLATSDSL
TGIANRRYFDEYLKNQWEQLSQEQAPLSVILCDLDFFKLYNDTYGHLAGDQALREIAQAI
SQAMKHPTDLLARYGGEEFAIILPKTSVADAILIAQSIQNQIEKLKIIHSGSSVSHYMTC
SLGIGTVMPSEKMNAKHLIEIADQGLYQAKAQGRNQYVVSALSHSIGQFV
>A0A8D9L3T3|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MSQTSDMKKRLPGIILITGGIVLVAMVIQAVILSFINNRSFDRTSQVLLDQVSNVIEKNK
ASEEDLIDSLKEDYMVRAKAVAYIVDAKPEVANDVDELRKIATLISVDEVHLFNTDGVIY
AGTNPEYFGYSFDSGEQMAYFKPMLDDKNLTMCQDVTPNTSNGKKMMYAITWNDDGTKMI
QVGIEPRRLLNEVKQNEISTVVANMPMYDGLSVVVADGESGEIYGCSYEPVVGLTLDEIG
ISVTDDMLPDDEDSFTGIRRINGFRNRCVFRRSGEYVIGVIYRMDVNSRSNMAIMVIMAL
YLCFAAGLVVSMVMKVIHANRERNEQLSILTSMSGMYYSMHMLDLQHDTFALYTAGDLIL
RVGERAAGAKELMRKIVHKVVVDEHQASAQKFMDLDSLGDRLIKKKIVSGEFMVKDLGWF
RLSFISIDVDEDGRPLKVIFTTRNIDEDKKREQKLIRRSYTDELTKCYNRSAYIDDVREL
PGDSVYVYVSMDVNGLKPVNDTLGHAAGDELLQGAAECMEQCFGNYGKVYRMGGDEFAAI
IFVNTRRLKRVQQEFDDVVRGWSGQLVKSVSISCGYVSSDEKDWESFDEMVKAADERMYE
NKAAYYRQEGVDRRYR
>A0A8D9P1T6|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MDRTAVFNIAFEMWGILICLFAFVVIFLQKNNNRDKKNVSLCMEAACIILLAADMLSWYY
QGKTGQTAYYMLKISNFAVFFINYLYMTLFTFYLLVILNRGETKMPAKARGVVVLSAAGI
VLLIISQFSDKLFYYIDDNNFYNRSSCYLLSQLIAAAGLVLSFSILLQYKKRLEKRVFWS
SVLYFILPCISTVVVIFYYGISFQTISVVASTQIMFAVDMVEMDRSLARSRQEVERTKYE
AEHDLLTGMYNKTAGMQRIREYIDNMTDEDSASLVFVDIDDFKSVNDTYGHAVGDYWIEK
VAKFLRSDCYEEDVACRYGGDEYVVLHKGLSDISVLESKVIRFARKLQRKTMERGQNVHC
SAGICQINGSGFSTEECMNVADTALYEAKKKGKNVSVIHSISRDGTDRVTVLDKIESDIK
KAQSRVEARIAYMYTDIIYVNYENNKYRVIKGDSELNNAVSCANNYDEVIGLISNRFESD
RSRKIVRDFLSRERMESYTGGNTGYQTENIRRGVLSVSCANNHGGASLIHVIPVDEDGDR
GYFVVVQDLDIYAG
>A0A7Z9DZF0|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MGWIIHQLNSMQYQCSPTKKSDSIKPTPNNQKLTNSGIKTQQRVNKLLHNSPVVIFSCQP
QPNYQITFISDNVKILLGYDVVQLLREKDIWHTYVPASDQDQWQNAFGQLLAKESHIHEA
RFVHANGNLCWLRVEMRLIKDKAKNVSEIVGYFVDITDRKEAEIQLLTTENRLKTVIETV
GSGITLSDQKGNFYIFNSKMTEITGYSLEDAQSHQDFLALLYPSSESYSQAQSRLKQVAL
TGSIFNAETTIPTKKGELKTLLLSTVMMENQENPLFLSTYQDITPLKRAEKTLCQLIVQE
HLIWEITHKIRQSLNLDDILNTTVMEVQQLLECDQVFIYRIFPDYRGKIIAQTNSNELLK
TKQSETPLISLESYEKFSQGRLRVINNINHDPIHPEMFEFLKYWDIDSAIMVPLFERNHL
WGLLIVNQNQGLRRWLKWEANLLRQISEQVGIAIQQSQLYQETQDQARRAQILNQVIQVI
RQSLDLDTIFSMAITEIINLFHLERACILQYLPETKQWQEVASCSYDGDINSPILSEIQQ
LYCLEIDDFDLPNCEEIQCLTGILGSWLPIPLRVGSEIWGCLGLLKHQDAMGWKESEIEL
TCAIADQLVIAIQQSELYQELQVANQQLLRLATIDGLTQVANRRRFDQYLEQEWQRLQVE
KGDLALILCDIDYFKQYNDYYGHLAGDSCLKKVAQALEEILHNSADLLARYGGEEFAIIL
PNTTRDEAINLAQHIQNAIAHLQLPHADSRVSQWLTLSLGVACTIPSSLVPSSSLIAAAD
LALYDAKQQGRARYCVQEVDV
>A0A174FL49|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MNDINKDEIDARWHMLVWRMMIVICSISFVIAWILFGVYRVDKSIGAGAYIVKYIVLPMI
VQAIAITICYFYMKHDEADIKHKNYVVTGMIYVCVGVIAFTYCTIYPLILIPCVTIIATA
LFADQELTVWSGVAVLALMVINVVRLHLNVGELATQMNWVGALLIYILVVSVMCAMVMVV
NKHTKALTESIAGSYNRQVTLMSELMVDPMTGLYNRRSFEESLDKEIENVEQTGAKSYVT
IFDIDHFKEVNDTYGHSNGDIVIKALCKMMKEKSKDMGLAFRYGGEEFVILFHDVELSKV
MNVVDDIRTEFRCYYFHFMNKDGITCSCGVAEYTKGESSKAWFNRADSALYKAKESGRNR
IVISE
>A0A0T9LHY2|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MNSTQNKSVKQTKNRPNTAKLPTLGRVLGRIHITVALVSVATAGIFLTLAALFALRVYAD
HNLHLVARSISYTTEAAVVFGDSVVANEALSLIAKNEEVAQAKILDVDGREVANWTLPND
GPMFDMEQKIARWALPEPVVLPIEHSGKKVGSIVIFGHGGNLLRFLLQGLAGLFICLILS
TIVALFLSRRMLFGIIESLNKITEVAHNVSRHRSFGQRVPSAKIAELNELSNDFNGLLEE
LEVWQDHLTQENDFLAHRAAHDSLTGLANRAFFEGRLSRTLSDCAADEQLAVLFIDGDHF
KEINDNYGHAAGDLVLTAIADRIRSLLRETDLVARLGGDEFAVLLAPIHNTDDVLTIANK
IIDSMNQPIDLVDGSEITASISIGIAIYPDHAQTPEDLLQRADEAMYQAKKSFPSGGVIT
HQSDITLTESLG
>A0A5E4VM76|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MSQTVANVMPESATLLEIVRAQTEIAKLGLDLGGVMSFVAERVQDLTQANGAVVELAEGD
DMVYRAASGVASDLLGMRLSRDGSLSGQCVKTGSILRCDDSETDPRVDREACRRVGLRSM
IVTPLRHLDTTVGVLKVFAPTPSAFPDADVRTLELMSELIAAAMFHAARYETSQLYLQAT
HDALTGLPNRALFYDRLRQAIHLAMRSSQRLGIFNIDMDGLKPINDRYGHRAGDAAIRTA
AERMHAAARRSDTVARVGGDEFGMILPGLHSREDAEAHRQRLMQQVGAPFEFEGNALELG
VSVGIAILPDDGTEMTALMDRADEAMYAVKRTRTTTRG
>A0A1C7FGY3|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTNKSKTKRFSTLQSRSKGMLLALSALLILANLYVFSETRQLARSYSEQQNQATWFLFQL
TKEFSSLVSVTPFALESEQYRKKAELSYELTWSRFDLLLNAKEADSFMQLTGAREFFSAL
FQRYISLEPELWKLTSKRQAMVLTNQLESIYQDMITYVNINFRIKSPIYQQQMDQARLLN
QTQWFLMSLLFICALLVGYILHLESNYNKHLALTDALTKIKNRLAMTEDVNRKIESQTQF
TVCLLDLNGFKQINDRYGHHAGDITLQTLAKRFENVEYHCRAYRMGGDEFALILPQQRQE
EMEQTLEAILSCFDEKITLSLETSVQLSASLGLASYPAQGSNFSELLKTADSNMYQMKFA
TQKRSIQL
>A0A329HSI8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RIT 418|TrEMBL
MNRKFREIDTTLIGLNQSTDAHFKWLVTVLRYVASKDVELMEITHEDAHQHCEFGQWLNA
QLLEERGDRHYLLDISTHHRKVHFACQQIITAIDARDVSSHSYDAFETALLGFTEALSLY
KVHLLQLRTSYDALTGLPLRRILDESFDAMNAGQEASGLYLMLLDIDHFKKVNDNYGHLT
GDAVLRSLALHLEDNVRRSESVYRYGGEEFIILLRAKSDREATAAAERLRRSTAEVSTVS
GEHTVRVTFTTGLSRVHRGEPLREVLERADMALYRGKQSGRNCTMLIGKNLDCMKVSG
>A0A087BDA6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium merycicum|TrEMBL
MLEAMSKPTEASIVVVDDEPSIRELLVASLHFANFEVSTAASGSEAIEVIEKVQPDLIVL
DVMFPDIDGFTVTRRIRQEGINAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVA
RIRAILRRTREQTEEDPIIRVGDLEINEDSHDVTRAGQSIDLSPTEYKLLRYLMDNSGRV
LSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVTDENGEKHKVTPLIETKRGIGY
MIREPRS
>A0A1Y6IZ17|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MFSVSGSSPRILLVDDDVDQINLLYQVLRSIGQVFFEQNGIEALKKSVNIQPDIILLDIQ
MPGMNGYEVLTKLKSHHVTALTPVIFITSHDSVEDQLHGLRNGAVDFISKPLQPPVVAAR
VRTQLMLRNRERQLADIYRHAQVTLDSIGDAVMTTDKNCYITYMNPAAELLTGMTFNEAQ
GKTIEEVMPLRIGDDGPSHVNPIRLAIQDKRVVGMALNCQMKCQNGQWISVEDSAAPLIS
ESGETLGGVIVFDDINESRAMALKMSHTLQYDQLTSLPNRFLFMDHLSKEMAKAEHNKKK
LGLLLLDINRFKLINEEFGFDFGDTLLKKIAQRIKKHLRNNEMVSRHNADEFMVLVPEMN
HPGEL
>A0A2T4IIE1|diguanylate cyclase|EC 2.7.7.65|Thauera lacus|TrEMBL
MHTNNLPLSGTMEADWISLFDSVPESTRNALRKVVDEHCEDMAVAFYARMMGDVDARPFL
THDAVEKRLRHSMQRWLSTLFSCADRDQFAAAMAMQRHVGEVHARVELPVNIVARGARVL
KGEIAHRLLQGGLDGEALVDAVLYADNLIDIAFEEMSSAYVASHERAARIDEAYRVFSYG
QNMSLERERQRAALLDWENRFLQEMMAGAAGDELQTLGDSSFGLWLHHKATAIFEGSSEL
PAIRLAIHSVDDNLLPLCAGQLENGEREETRRLIKAVQAELGQLKFLVGAMFERFVDLES
GKDALTQLLNRRFLPAILSRETEISRNQGKPFALLLVDVDHFKHINDRHGHEAGDRVLQQ
MASLLLNTVRSGDFLFRYGGEEFLVLLVEVDEAHARRVAEKIRSRVEQESFLLADGRSLR
VTTSIGLAMHDGHPDYQRLVNRADDALYRAKHDGRNRVVIATE
>A0A0T9NUC9|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPKTPAMTLPIVMITAISLGTIAY
LILISKKYADKLNYFSIVLGVLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FIAFCLHTAPATLAVIFLDDFQNIFRILFTIMLPLIGFSLHHLMSRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVEFAGKEFSNAESSP
>A0A2L2M1W4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SWBY1|TrEMBL
MYQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSSSEQVQTITEF
IYQVDELIQKIGQCESQAQAIEMIQSIRAKNREILHLVDQIFQVSEYINSGNDALTQLLN
RRYLNTIVSREINFSRKNNSPLTLLAIDADHFKSINDRYGHAAGDDALQFLADVILQYAK
GSDYAFRIGGEEFLLLQIDTTIDRALVVAENIRKRVEKATLKTSTGEEFNFTISIGVHEY
DGHPDYQRFFEEVDKALYMAKNNGRNNVSVG
>A0A0T9PPG5|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MLTAHLDALNILSTPIWVVTPKNQELLFANKEARKIAGDCQLPLMRNGRFSAHAQQQLDA
YLPAIVGDDQIVEIWTIEREGNAFPLSCRLSLTQLEPYGDVIVFEGLYISEKVLTQPQVG
QPCSTSYRRDEMGFYEQFFNTNTAPMLLIDPSKEGQIVDANQAAIRFYGYSRDEMCMKHT
WEINTMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNIRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEQAHAQSQRYGHHFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIIRESDSVFRWGGEEFAILLPLTNLEGALQVAESIR
ETIQMICQPNLPQLTVSLGVAQHQIGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A8B4TT20|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MDKSLRLTLKKLHHLTRPSHVVNVCFIVVLLLSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRRLEAWRVALPNRRTL
PVFGVSGSVVSNNPMLLADDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDEAQVRAHYSQAVNALWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVNEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWSKLRNFDGVLLRVHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLAVIQLDLDHFKSINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCIVL
PNTTLREAAAMAERLRLRIQGREVFLHNNVTLRVSASLGVSASEEQGEYQFEALQSVADR
RLYQAKQNGRNQVCFR
>A0A7H4MTR1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MGRSLEAALVFGDSAAAEDTLATLGRQGQFSQAILVDGRQRPFASWHNDGLVSQDKISDV
ISKWLFPKPTVQTILHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTH
SLHRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQ
AKNAQLLRSSFTRPANRAG
>A0A7H4MTR0|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDETAQSHSALLFLDGDNFKLINDNWGHAAGDKVLIEVASRLMAFVGKQHQAWRLGGDE
FAILLRDVHSETEVRALCSALSEQFIPPFNLHNGHTASLSLSIGYALTWEHTSAENLQEL
ADQNMYRMKHQRLQQTQNKRNHHDRKIFCSCFTGRTFS
>W8U5W8|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium acidaminophilum DSM 3953|TrEMBL
MDYSKLTKEELINRITELEMLNRELLREKEAETRLDFAWTGNLGHWYWNIQTNSVVFNPL
KVTTLGYTKEELPQKVTYQFFTDKLHPDDYQNAMDAMLLHMKGKKSVYEVEYRIQAKDGS
WKWFYDRGKITQRDGEGKPLFASGIVFDITKKKEQEISLKKKNEKLRKSAETDALTGIRN
RRAIMDELESRVLEASINKSPLSIAIFDIDKFKAINDTKGHVVGDKVINEVASIIANTIR
GLDSAGRYGGEEFLVILPNTDKTNAAGVAERIRKNVESHDFGEGFKVTISGGVKQFQGEE
KTELIDGADKNLYEAKNGGRNKIVV
>W8TKA8|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium acidaminophilum DSM 3953|TrEMBL
MKRTTWFFTATVTIIFLAAIFTGMQGSEHYIAKLHQNSIIAEFFLMGFMLSMALYHIVIA
SFIKRQRAFFYFAVFCIIMCVRIMITGERFVLDTFGWISWEMAQKLEYLTFYSALPIFLK
FMDTLFENIFGKKMNETIYMITAVFIGLVLIFPAAVYTKSVFLYQLITLASGIYIVQKLY
EAVKLRRTGSFEILIGFTLMLVLVTLEILGTNGYEGYTGYNGMTFWGVMIFFFSMAFGIS
KQFSLAFIQMERLATENKLMLGKIRKLNRALKKRNTELADKVSRDGLSGLYNHRHLHEKL
HEKIEKAVLVNSSLSIGMFDIDRFKDVNDSYGHQFGDKVIVEVARILAENTRSRDIVGRY
GGEEFMIIFDGVDSLDCTCISDRLREKVSQELKASLGISITISGGVVQLQQNEKADEIIQ
RADKLLYKAKENGRNRIECEKELA
>A0A2J5P8V2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
DPLWSVEIHNRRTLPVYGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGF
AKRMLYVSRNGFFTTTEPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEA
SQREMQVVTASIPLDFQRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIA
SSAPGNVLTLLSPREQEMLSRASSHESQGGIRLVTRYISWENLRNFDGVLIRIHTIREGV
RGDFGSITIALMLMWLMFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGA
LFERATAETRLSERLKRPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGD
LAGRVGGEEFCIVLPNTALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDS
GEYNFENLQSVADHRLYLAKQNGRDRVCAEG
>A0A7H4LUX5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNLAVRNGTPLSCLMIDIDHFKAINDSYGHEAGDLVIKNVAAIIQRAVRDIGMAFRYGGE
EFLVLLGGTDEEAAMACATDIYHSVQLLTLRYGLAEIGQVDVSIGIASYPQHTQSDSLLR
AADAALYRAKELGGREL
>A0A1V5DFR2|diguanylate cyclase|EC 2.7.7.65|Smithella sp. PtaU1.Bin162|TrEMBL
MSLHDKQPDNLPLVLIIDDSPEYLTMLSDILRNNNYSVCAAGNKPAALAALAGNTPDLIL
LDVKMPDMDGYEFCRHLKSTERDRDIPVIFISGLGDASDKVKGFKAGGIDFIAKPFHMAE
VLARVATHIDLNRLQKQLAKQNIRLQQEITERRQAEAELKNHKSLLEETVDRRTAELKNV
NEELQHEIAERRRVEDALENANFKLHSMVYEYGLRHHRVSLFNQMSEHLQMCNSLEEAYP
VINQFTQKIIPRIPGALFIMHPGNNLLEAVTSWGKAIRGKKVFSPEDCLALQKKEMHVTP
ASATDISCTHLTGAAESDCLCVPLLAQREILGMLYLQKPPVSSSARSAYEDSSPEFGPDT
QQQALTLAHYLSLALSNIKLQISLRQQAYRDPLTGLFNRRYLEETLKREIYRAQRHKTPL
GIIMLDLDRFRDFNNTYGHGAGDLVLHELGQFLQNNVRKEDVACRYGGEEFTLILPGASL
DVTRNRAETLRQKVQQMKVYYNDRTLDQITTSAGVAIFPEHGPTGEAVLQAADLALYSAK
YMGSNKVMVSGNGTSDYRKTT
>A0A1Z5I045|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MVHYKYLHRRSFVRDGLWLLAINAILFAFFAHYDVLEVIINLVKEYEHWELDEFLPLGAS
LTFSLVIFIYRRLVELGRVTQAFEDLAKQDPLTHAYNRRAGQVILHNFCQKAHREGEGFS
LLQLNIDNFKRINDCYGPSVGDDILIKLVAIIQKNIPAKSELIHWHSDNFLLVLPTSITS
PYEFANNLRETIAQQLFTTDTITCSMGLATWQKGFSLSDMLHNVEDALLDAKAANKNTIK
VA
>A0A143QDE0|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MNTARRLEASTALVAYLGLTSILFVAGAVAFSGTTSGTVVMIVVGVAQSVAAALVHFGPH
PTPTRTLGIATGVAVGGLWAVFLTSDGAVAYLLLTQAAMLLAMQLTGYWSERGGWVWVVV
LLAGCVVAAALSPSTMPAVAYLLTALGIVAAAEFFGNHSRRMRHSANRDPLTGLLNRQGL
EARVEKLLPTYAARGLPVSMAVLDLDNFKTVNDRYGHIAGDVLLERVAASWRARLRKGDV
LGRLGGDEFVLFMPGTTEHDAAALLDELRLAHSAEWSVGLVCMPTVRRWSEIYRAADAEL
YRAKRARGADRTDRPVPRAVVEDAGAPLDVTRRPPS
>A0A4Y1MZU4|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MPDGLETIGVIGQILDSQGLALCLFDAEDRTLLWNRTFLRFFPEHDGHVHVGEPYASNLE
RFYAARLSGPEHDRLPEFVAAGIARHRTQTRPFSFEHRGRRLLVSSLPLPQGGRVRVWKA
LAEALPASESRMPVDPFAHLADGATVLDREGRITDANQEFVELYDLPSKEVAIGRTFREV
LQLLWEGQADAALDAFLDNARFAGAPFEVELPGDRWRRVIERRMEDGTGYVSHADITTLK
RQQRELQEAYERIATMAVTDGLTGIANRGHFEAVLEEEARRGGRNRQPLSLLLIDIDHFK
RINDRFGHPTGDTCLRMVARYIDRGIRRPGDLAARFGGEEFAAILPGTDAEGARVVAEAI
RLAIEGDHTHDFNASQPVTVSIGAASLTPAPGGVEDAGRLIREADDALYRAKRAGRNRVI
LAA
>H6LJE5|diguanylate cyclase|EC 2.7.7.65|Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)|TrEMBL
MSHLNSHLKKIKLHFSKEKKLNQSVEDEMIAKNASRLVVLIPAIGVVNLAHIFYFIINFT
PTTLLEEKWVTGIVFIHAVSAVIALILTLTFIHINKKKATYLHLKIIENFVALFILILGI
SLVSVDQYVTTNITPFLVVCTVLGLFIIKRPLAAILQYAVALISFFVLMTIFQTEPAILA
TNQLNGITFVAIGLCISLLSWHSGRSAILQQRKITEQHHKLEEIAYYDHLTGLINRWKWL
QYVDVELEKNYFPGKESCILLLDIDFFKQVNDQYGHPIGDQVLKQLAQILKNEVGSQGDT
ARWGGEEFIILLPGVSLSKSIAIGEQIRQRIAQTPFNIENHQIHITVSLGATLLEHDSDF
MDAYKRADQALYIAKNNGRNRLEYIVDPA
>A0A6I5AGF6|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MSKQSQHVLVTLPHPLLRMASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPVLGGLLLWLLLPKETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETVITLLVTLTLSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSMMLAAAPSLLYIPKPNLTTSLPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLNNDL
EQLDMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRNSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAKNVIRDSLAARAPFKLEFRIAVKDGVRHIRSLANRVLNKDGEVERFLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDEKNHVASDVMSQADIACYAAKNSGRGRV
CVYEPQQSEAHAARSQLSLDEQRHTITHNPMLIIARGVASPRIPETFSFWLLSLRLGTAE
GEIIEEHAFRAGLVDSTLNQALDRRVFTEFFQSAAPAVASKGLSIALPLSAAGLLNTELV
DELLGQLQRSPLPPRLLHLTVPSNVIKTNPTQAISTLHRLRQCGCRIILSHVGRDLDLFD
NLKYHMVDYLLLDSELSASVHGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSHFAIN
>A0A127MMR4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MKQSSESARFSRSYAQRVLLPRAVGLAVGFFCVAGVLWGKGHSPWLWGLLLWFCYLWPLM
AYQITSRSPRPKELERRFVLFDSLMGGFWIATIQFNVLPSVMMLSMLAMNNTAAGGAWFV
AQGFVLQALGMVLSGLVLGFGFSPDTSQAELYACIPMLVIHPMTIGLVLYRLAIQLSRHK
KALRDLSRTDSLTQLFNRGYWKERLQQAFEHCRQAQKPASLALIDVDHFKTTNDRHGHVI
GDLVLRRLSEFMRSHLRAEDLAGRYGGDEFCVLLPGLQPEAAREVLARLSRELAGEEWER
VPELRVSLSIGIAGFDPAMPDATEWLRRADQALYEAKGQGRDRIVLASELDAAARRA
>A0A8J8AKD0|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
IPRDTAKGALQRALEELNKMQFEGDRGEIFNISFSAGIVSFPDDCKDIDELLRMADERLY
KAKDAGRNCIINS
>A0A8G0UN91|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MRRPYKREDIGQSIAGAPSFEPLIQSDNGSYIGTATLDGAQRLYSFRRIGKYPLIIVVGL
AIQDIYAQWTQRAWAIGGVVTVLDVLIIWMSVMFARLFRKRLEMENRLHLLATADSLTGV
GNRRVLSSTLETEWKRASRDGRNLSVLMLDADNFKALNDRHGHAIGDEALKAIAQCITKN
IRRPGDFVGRYGGEEFSVLLTSTDMNGAIRIAENIRAAVMATELTSMGARPVPLSVSIGV
ATFDGKNARAESSEQLLRQADRRLYQAKAAGRNTIMPRQAHGQAAMVGDPHPST
>A0A8G0UZQ3|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MFQSHMIVLIAGVFALQMAVVCAVLRRTPGMAMSGLTSWALGDLMAALAAVMPVAAGFAG
YWLAADAVDMGLFSAVSLMVVGTRHFAGKPGRASVLIAANVLLVAAIAGGTWLTHADWLE
PLRPWMPAVLRLGHVLLLLDLARSVAPLLAQKRGTGRLAALSLVVIAAACAGLNAWKLAG
SIGQPAVAGPLLRDGSLVVLNVFAVVGLSVSFALMAHDRLRRMLEHKASHDDLTGLLART
AFWQALEAASTHVDRHGKPLTVAFIDLDHFKAINDVYGHLAGDSVLRHFAGLLRKTAGPE
DIIGRLGGEEFAVVMPDTTIERGRAVSMHLSTTVRNTPCPSEPDAIAYTASIGMAQREPG
ESVDSLMRRADQALYDAKQRGRNCVSLHRATKPSHGVTLGGSAQWQRRAAS
>W5SQP2|diguanylate cyclase|EC 2.7.7.65|Borrelia parkeri SLO|TrEMBL
MTKSMILDNFEEISVEPQKLLLVDDTPTNLDLLIDILQHKYEIRVALNGFDALKQVEIAS
PDLILLDVLLPDVSGYEVCKRLKNDPETKDIPVIFISSSDSTDAQLEGFSVGGVDYILKP
FNGRIIDARIKTHLELKRLRDYFKNLARIDGLTQIPNRRFFTDKFAKSWMQALEHKNNVI
VGMLDIDYFKKYNDNYGHTNGDECLRLIAKSLNKIAIKYKIDIARYGGEEFILFSVNKSL
NEVIKIVSILIEDIRNLEIIHEYSNISNFVTVSIGLAEQIPYDSNFTNIIKLADDKLYEA
KISGRNQCKY
>G2DH68|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MNKISPCQILDPIETAQNRNRAAMELLQQHQIPPSPVCYAVAYEYVAQRTPTLNQALDQH
LEKHGSLNPHLLREFFETHFEGGTELQLDDHIASLHDTLYKVLEGVSSACHGISDFGRLL
EGQMESLQGQTDLGSVRRIADTLLQATNQAISNNQKIQDNLASAERNTTELRNQVEQLRE
EAHRDSLTGLYNKKVLNQRLSQCIESSIESQTTLSVLMLDIDHFKHFNDSFGHLIGDEVI
RRVAQTLQQRARKNDIAARYGGEEFTLVLPNTSLEDAIKVAEMIRSTVGKLVLVRKSTKE
KLPGITISVGVASLHPEDSIETLLERADQALYYAKNHGRNCTISESLLITETDSNNQKIA
Y
>A0A2U3QIQ9|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MGYLLISAALLIVVIVTVVAYRKGEARGLHDNDTEENKKNKALLKEISSKGQLVLDLQAQ
IDALNDLNGRYLTFMFTIPSIVKRLNASQHFDEVISSISRLIKDVISTDTVEIYTLDREN
DILQKVSSEGEAPEAQCTYALGEGLVGAAAKDGMLRTKDTIPKGRIIQNNTGQDKSDIWM
AAPINFDDSLIGVIGIGKAKKRTGNEGNFMKMIADVAGVVLMNQALLGDTKHKAETDPLT
GLYNRRYFFQMAQNAVEKSIMDHSPISIFLFDIDHFKNYNDTNGHDAGDRLLKELSSVTL
KVTRKTSVVARYGGEEFIVLLPGLGKEDAFTYAERLRETICSHPFPNGDMQPLECVSISG
GIASFPADGGSIKELVSLADTALYQAKSEGRNRVAKHKPFFFSEAEVVK
>A0A380SUW4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MTETALQKLLLKRFLMAAGTYLLVLALVWVALLSGHLQASLNALLLGSGLLLVCQLLLGW
VFASGRNLRFNDPSLTEFQVLLAIAWQTWLLAQLDQGRGTFLMFYPLILMFGLFHLSGRV
FVRCALLVLCSFVGLIAWEAWQAAHFDGSLLALQACALLVVLCWLCLYARYVQAARQRMR
QRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLSLATCELERMRADSCHGLALI
DLDHFKRINDVYGHAAGDQVLQVFATIASDCLGDTAVLARYGGEEFVLLLPDCSEEQLAS
CCERLRKAFALAQPPAVGLRVEPLSLSAGMTLLSEGDDLDDALQRADQALYRAKRSGRNR
CLAAWEAVDA
>A0A1C5Y1C5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MANGLAVLMMGYLLLCRRKNRESLHAEDKIYDGIALVNILGALSETVAFLIDGKSFTGSR
QINYAVNSLCFIGTVSMSLLWCLYVELRIYRNYKRIFSKIAFLIFPWLVEVIMILCNLFR
PGIVFRISGANVYQRAGGSLACYISVIMYFGYSIYLVYHSRKQGINLSYFPVMYFVGVGF
AGVILQLFFYGITASWLLAAVTLIFVQMQLYAENLYTDELSGLYNRRYLNAVLAKRKTAG
WKSLHGIMMDVNDFKHINDSLGHSIGDKAVSTMGSILFRSIPDTGMAIRYAGDEFIVLLA
GVDTECVLATMDEINDNISQFNSSGAEPFSLSVSMGYAEFRPEDDTETFLRNMDEKMYEK
KRKYHSLNQAERLKKDQQKI
>A0A1C5SBT1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRIKDNVKSVYTQIIVLCEIFHISFLFIFKHFSMQIPFMYNIGSVIFYILMLFVVLKGYY
RVCIVLVHLEVSAFVTVTVLNGGYSSDFALYLISMATFVYFNPFKHRSVTYIFSICEVLL
YIGLTLHCRHIYSEAEVHIVFVTIYNTVLAVGIILIGAYISDVSATVTHRKLIDENKTLN
NLANYDRLTGLQSRRMFMERIKDSEDNKSVVICIGDIDDFKKINDTYGHLCGDYVLQNIS
EIMRKSLGLENVDICRWGGEEFVFMFCNDDIDSAFVKVENLRKTIENKNFVYENNNIYVT
MTFGIIERDSGKVDDVLLESADKLLYRGKINGKNVVVKA
>A0A1C5R1A8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKSSVDVLTGVFSRLAYHECLEQYADSVPADLTVFLMDINGLKGVNDALGHQAGDRGKIF
RIGGDEFVVLGQMTQAQAQEILAALQRIAAAWSGTKVGTLSVSTGCAFAGDHPDFSVERL
TQAADLSMYARKQEYYRAKKLSSGTPVSSGNGVRP
>A0A8H8ZJW5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X2IA49|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLASLNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCEVYWQ
>A0A7W5J6H9|diguanylate cyclase|EC 2.7.7.65|Pseudoxanthomonas sp. OG2|TrEMBL
MPLERANRIDEQTRSRFGFRTYRMRVLGLGLGTLCVGAVLHEHGDGPGLWLLLLFNGLVW
PHLAYWRVRRSADPINDEYRNLTFDAAMGGFWVAAMRFDALPSALLAVMLTMDKVIIGGP
RFGARTLGAMVLTCLAASAAWGFAFEPRTSYPVVLACLPFLAIYPMAIGFATHAISRKAQ
QHKDLLEKMARFDAATGLMNRQQWLYAVSVELNRYQRARRPAVLVLIDIDHFKQINDTRG
HTIGDGVVEEFARLMKACLRDADTGGRYGGDEFGIVMPETQWEDAIVAAERLRRQVAAYA
FTRDGLRCTVSIGLAEISPSMATVSDWIDAADRGLYQAKRKGRDCIVVG
>A0A7Z7HUA0|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MYSMHKPAPNWLIRLVEKLPHHKTTPQALALRYGFALATVALAYLGREFVGPSSVGLPLL
TFFSAAALTLILTGIGPGLLAAAIGMSIGTCFYMPPYGVFTFEFASGNVLSNLVFAFNIV
LLSLVVKALQIYFDRYLANRRLLSAIVEGSKDAIYVKDLQGRYRFMNAAGKRYLGQAADA
TLEQSDGVMFSAETRAQLAAQDQQVLAQGKVIDFETAIDTPGGRRIFHSTKGPLQDEQDR
MIGIFGLEHDITRSKQIEEALQEKLAIQEQFVNLAALVPGTICTYRRNASGLPCFPYASA
SLGEIFGLSPEEVREDASAAFARIHADDMPHVLDTTQQAMNYGSIWNTGFRVNHPQKGEI
WVEGFLRPVQQADGTTLWHGYLQDITTKRHAEEQMHLAAGVFDTITEGIVVTSPQNRILA
VNEAFIAMTGYTREELLNQTPRLMHAERHDAAFFEAMQRKLLEHGRWEGEVWNRRKNGEL
YLKWLSVRVIRDGAGNLASYISVFRDISLVKNSEERVEFLGTHDDLTHLPNRTLLNDRLR
QAVNRAERSGHRLALMFVDIDNFKLVNETFGHTLGDNLLLQTAERLKDCVRCEDTVARMG
GDEFVMILEDCERDAVIHTAERILARLSEIYRVGGQECFTAASIGISFYPDDATEPSDLL
RYADNAMYRAKEKGKNNIQLFSEDMAERSRKRLEIERSLRHAIERNEFFLEYQPQIDLGS
HTLIGVEALIRWRHGGKTIPPLDFIPIAEETRLIITIGEWVVKEACRQIKVWDRNGLSPF
TVSVNISARHFLDPNMVIRLHSIIQDAEVDPRRLCLEITEGAMEDIDNTMTMLQELEELG
FRTSIDDFGTGFSSLSHLKRFPLHELKIDRSFVDGIIDDQDDRAITSTIISMAGNLELSV
VAEGIETTEQLQELHGMGCQIGQGYYFSKPLTADRFNEWLSNRKSQT
>A0A0E1BWB7|diguanylate cyclase|EC 2.7.7.65|Borrelia hermsii MTW|TrEMBL
MQSFDNLSKDIKNFSYTIDKDFLVWPKNSLLNPINTELIEKWGLKSALKLQRTFFDETLI
RETKKLINIEYDEESIANYHILISNLEEVYETCKKNKKIYYQDVLPTIKKVMEFYKKNQQ
TFIKYMKVPKLLSDYHVVHSINTAILTVALGNEMNLNNHKTVELCTIALLHKIGFLFIPP
RISEKKEKLSDEEFQVIRKYPILGYKILSTTNFSQSICLAILTHKENLDGSGYPNKLKSE
KINIESNIIGAASAYSAILLEKTYKGALNSGASLIELIQDADRKFDKRVLKLIIKVLSQC
PLDFIVELNDNSIAKIIKINEINVNVPYIKYIIKDGKIVPPSENHNYVKSIPKTETGIKK
ILRQDEIEFILKKYGLKEM
>A0A1C5RJJ1|diguanylate cyclase|EC 2.7.7.65|uncultured Dorea sp|TrEMBL
MPNYPDSIQDLEPLSGLYIRKRFLNEVRTFLDQKHPQGWCIVAIDIENFKLFNDWYGQDS
GDYLLLEIAAYLRNLHQEDNYITGHFSADDFFICMPDDSHKLRHIYATIYHYIDKLEQDD
SFFHPSASIRLKTNL
>A0A3G4VXW5|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI95-16|TrEMBL
METESEPYVRLATLRQLHRVVAELNTARSLADTLQTVVDGIVVGLGYELACVNLVRPDGD
LVVAAFAGDPAAEALITGRVGSRASWDRRLTMGENWDGLRFIPHSEGWILLEDDVPQWHT
DGPDPRFEDEWHPEDRLYAPMYATGGELLGVISVDRPRNGRRPGAWGREALQMYAFQAAI
AISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLRTN
DALCRLLGRPASVLRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVWVSLRNS
VVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRSRLGARLCRRPQ
SARATAIEALDAAYEGRGPVPEPAGGAGEHGFRPDGPHTFAGPDPFDFPGGPAGLGPPGG
GPGEAGPYDHHVHAVAPATDVDDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARR
LTTGVRDGDTVARLGGDEFVVLADGLGAADAADLAVRLRNAIIPPIRVDGRPVRVGASFG
IGWASCGMSADEVLRSADQRMYIEKRSRSKAHRRAG
>A0A448E0R4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTHNAIQRLLLKRFALAAATYGLALLLLWLAFFTGHYQQPLSGVAIGSALVVISQATLFG
LFWSGRNQRFADPSLTEVQVLMGLGWQTWLIAHVDEARGAFLVFYVLILLFGLFHLTRRV
FIRCALLVFFSFSAITLWDAYHFRLAEPALAALQVCILAMVLAWLVLYARFVQVSRQRQR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRIASRELNALDSDVVHGLALI
DLDHFKRINDLHGHAAGDQVLQAFAAVAQACLRDGDVLARYGGEEFVVLLPDCDAERLTA
CCERLRIAFTEVELMGLQVRNLSLSAGMTLLAVGDDLDEALQRADQALYRAKRDGRNRCA
AAWENVDA
>A0A5E7F6U5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLVQDIMENQRGKGLSFARRIYLPRIIGLGIGCISVAAALYPLSLPIWVWVLLLFNGYV
WPHLAYQLSTRSTFPYKAERHNLLFDSLCGGFWVATFEFNPLTTVTILAMMAMNNVAAGG
QRLFIQGSLAQVAGGTISVLLFGAAFTPYSTQMQVWACLPMLTLYPLAVGMVCYRLAIKL
SKHKRALSALSRTDSLTGLLNHGAWKDLLQLQFQRCRAHQQPAAIALIDIDHFKSINDTY
GHIVGDSVLRKLSAELKRNLRECDLAGRYGGDEFCVILPGMPLHQARDVMERLREVLHNY
RHQEIPELRISLSIGLAAYHQSFTDAIAWLDDADKALYTAKNTGRNKICLAARDTERRTA
VAQAI
>A0A5E6Q077|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAAEGNGLPLASRLYKSRTLGLTLGFVCVVFGMYPLDPAWWVWAWMLINAFVWPHVAFQ
LSLRSANALRSERRNLLFDSFCGGFWVGAMHLNPLPSVTTLSMMTMNNVAIGGPRFMLAG
WVAQALGIGTSLWVFAPAFIAVTTQVQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLELEFQRCRRGSAGAAIALIDIDHFKVINDTYGHVTGDI
VLRQLGKVLRQNLRATDLAGRYGGDEFCVILPDMDLNRATEVMDALRNRFNALAYAQDPT
LRVSLSIGLAPYQPNHADSTSWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A5E7A8Z8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSQSESRANVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGQDPELNR
HLDRVLRDFDGCPPESASRLFREYIIRDELEDVRAEQQQVFSLVDGMERDVSRSVMGSQN
FQNRLGQCLEMLDEPVSDRLPGILSELQQSTRVMQSQQERFLGQLQSAQNEIKTLRDKLE
RAQRAATLDGLTELLNRTAFTRLLEQALGKASRRVALVMLDIDHFKQFNDQYGHPLGDRV
LQHVGQVLRGALPAHAFAGRYGGEEFCVVLEGCADLASARAYAEQLRLKVQSLRIKARGT
DTVLDTITASFGVAFAEPGDNLESLVTRADDGLYEAKRNGRNQVHALQKSPVLQP
>A0A174UYR7|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MRKKNEITEYVAAALIFVCAVAVSLGIFLVCTQNSIERNSQKVIKTNVSRQSEHIKAILD
IHYGYLRGIAKEIGKSEELVSDENMEMLISLEEETALERTALIEADGTAHYDNGAEKNVS
SRRYFKEGMEGKETLSDPLESSVDKETRVILGVPVWKNGKVIGVLGGSYNVTALSRMLFN
DFFEDVGYTLITTSDGEIIAYDGDFAYHEIEYGDNFFEFYDDQTLIFDSSLTEVKKDFTV
GADGLMKIRIGNDYNSDRYLAYTDMGLNDWMICYVIPVSEAQKSYNFVRRYELIFTIGFC
VMVSMLFLWGFVKNRSKNKQLIQAAETDALTSAYNKRSTEERIHNVLQEHPQEPGTFVIM
DVDHFKEVNDIYGHITGDKVLHKFGEVLHEHFREGDIVGRIGGDEFVVFMRKTDSREVAV
SRIESLIKKVKELTFPEMNGKNITISAGMAFAPEHGTGYLDLYKNADTALYKTKQNGRDG
YNIYEEEKR
>A0A0D0TBU7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRRGKGLSFARRIYKPRIIGLGIGSISVVGALYPLSMPAWVWALLLFNGLAWAHVAYQ
LSTRSPFPYQAEQRNLLYDSLAGGFWAATIQFSPLTTVTILSMMAMNNVAAGGKRLFLLG
LLAQAAGIAVAWGLFGVKFDSGVSLIEVYTCLPMLTLYPMAIGMVCYQLAIKLSDHKRAL
SALSRIDSLTGLLNHGSWKDLLNLKFHKCQQQQGQATIALIDIDHFKNINDIHGHTVGDT
VLRQLSHELRQHLREDDLAGRYGGDEFCVILPRMPLEEAAQVMERLRETFGNYRHPQIPE
LRVSLSIGLADFHPSFDDAVAWLNAADLALYAAKDSGRDRVKTCDWIAAYPT
>A0A5E7U360|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLDPPLWVWALMFFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGSRFLLAG
SAAQLLGVGVGLVVFAPVFVPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFAILGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKAGGRNRVICNCDGKPRRTLLDSV
>A0A5E7JGZ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKMGGNGLSLARRLYTSRILGLVLGLLCVGVAMYPLNPAPWVWGLMLFNGLLWPHLAFQ
WARRAARPYHAEHRNLLVDAFMGGFWVVAMHFNPLPSATTISMMAMNNAAIGGLRFLLAG
SAAQVLGMGVGWLIFRPVLVPETSQLQLYACLPLMCFYPLALGLICYRQAHTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQQQGAAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKILKQNLRATDVAGRYGGDEFCVILPDLPLNSAAAVMEGLRDRFATLGYEQNPA
LKVSLSIGLAAFNPGHTEATLWLNDADQALYEAKSTGRNRVICCGDGRAHQELLDSV
>A0A5E7FAZ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MWPRAPAKNRFKRLQLLLIDIDNFKLVNDLYGHTAGDRLLVALSEMIRSALPDGAVAARL
GGDEFAILLGRASNERILELGSALREQFHQAASQTFATPEAVTLSIGATLFDHPPTSLAA
LIEQGDTALYASKRGGRDSLRLVDRTLASSEPQRVR
>A0A5C5Z4J3|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MLQGNAMMMAAGSAVALVLIAIGIAIGIRIARNRNKASQSSMSQEERERILQMLHELGAW
TSEYSGNVSQYQTRLGELNDAVRVDPSVNKTAPKVVSLLQQIMESNEALQTRLDAAERQL
DKQTKQIESYLTEARTDGLTGLYNRRAFDQRLEELFGGFRKGGRSFVFVLVDIDHFKNFN
DTHGHQVGDQVLQQVAKTLRLELQGAIMVARFGGEEFAVLMNGPLRIAAEKMNEVRKSLA
AQEIEIGKKHLSVTISIGLSEPRDDLVVSPVVRRADEALYAAKNIGRNRVYYHDGKGTSL
VGAPEVARG
>G2FG30|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Tevnia jerichonana|TrEMBL
MRDMERENRHLKQRLKELSNEARRNETTLNRFHQRELELLSAGSLAELLQHLTDGMRRSM
ELASICLLLEDRKHHLRDLLNNNGIPAESFPAVRLVDDLQQAHPHLTSLQRVWLGPFLVP
EHAGLFDNPQQLQSVALLPIPRRGKIIGWICMGSRRHDRFTRHHASDFIEHLATVSGVCL
ENAANRERLLLSGFTDPLTELYNRRYLDRRLPQELSRSHRYHQPLSCLFVDADHFKQIND
QHGHSAGDQVLQELARRLREQLRASDLAIRYGGEEFTLLLPHTTLKEALRLAERIRQRVE
REPVRLESGQTIPIRVSVGAAQSLPPPPDLQPDLESIAKALLENADQALYLAKSNGRNRV
ECINPQARS
>A0A1C5V1F5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLE
ITGNQNDELIKYLDDILLGLRYQDGHYDLVKFNDEEYQEKLQIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKEILKSLSREKER
LNSCENQLPIDYACGWALSSDDMACIMQMLLDDADAYMYKNKQLCKKYN
>A0A5P9JC91|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MQLASNQGDSRMSMLPGSDAQTLLALMHARAEAERLGEREQLFSTLLGGVNAVLWAFDWQ
AQRMIYVSPAYERIFGRSPALLLADYGEWRNAIYPDDVEYAQKSMLAVLDEGAVETREYR
IIRGDGQLRWLSDKCFLGRRAEHGHGPIIVGIAEDITEKKQLEGELQRLATTDVLTQSSN
RRYFFECARTEFERARQFASPLAFLLLDIDDFKRINDTHGHQMGDQVLQKVARCGASVLR
QSDLFGRIGGEEFAALLPGCQPDLAEQIAERLQREIERLVFTAENGERFRVTASLGLTYL
KASDPELSAVFARADAAMYTAKRLGKNQVIVG
>A0A2K8PF68|diguanylate cyclase|EC 2.7.7.65|Streptomyces lavendulae subsp. lavendulae|TrEMBL
METESEPYVRLATLRQLHQVVAELNTARSLADTLQTVVDGIVRGLGYELACVNLVRPDGD
LVVAAFAGDPAAEALITGRVGSRPSWERRLAMGEDWDGLRFIPHTEGWVLIEDDVPQWHT
DGPDPRFEDEWHPEDRLYAPMYATGGELLGVISVDRPRNGRRPGAWGREALQMYAFQAAI
AISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLRTN
DALCRLLGRPASVLRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVWVSLRNS
VVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRSRLGARLCRRPQ
SVRATAVEALDAAFETRPEAGGAGEHGFRPDGHDGSDYGYPAAGAGAGAGAGAGTGAAAG
SGAAPGTDPFEFSGAFTSHADGPYDHHVHIVAPATDVDDGTKGLAVLFCDLDGFKSINDR
FGHHTGDAVLIEVARRLTTCVRDGDTVARLGGDEFVVLADGLGAADAADLAVRLRNAIIP
PIRVDGRAVRVGASFGIGWASCGMSADEVLRSADQRMYIEKRSRSKAHRRAG
>G2FE35|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Tevnia jerichonana|TrEMBL
MEDSQAINALLRAELMELAGVASEGAATLEQTKALLAERPERFFIAVLDLNLPDAADGEV
VDYVSQFDIPIIVLTGNLDTSARQRMRQDHLVDYVLKRNASEIDYVCNLVRQIRDNYRRK
VLVVDDSRSFRLYLRGLLSVHKYQLLEAANGKQALQQLKANPDTVLVISDYNMPGMDGAE
LIEIIRRDHRREELAIIGISDRTKAQVSARLLKAGANDFITKPFEVEEFYCRVMQSVDMI
ARVCQIRNAARRDFLTGVYNRSYLYEQGEEMYARAKKSAAGLAVAMVDADHFKRINDRYG
HQAGDAALVAIANSLQQSLGEACVVGRYGGEEFVCLLPGASESLAMQQFERVRAGIEALS
IQNGGDSFQVTVSIGVTLDPGESLEQMITRADQGLYQAKAAGRNRVELN
>A0A8H9B523|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MFPKIMNDENFFKKAATHGGEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKADAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A517ZRZ1|diguanylate cyclase|EC 2.7.7.65|Symmachiella dynata|TrEMBL
MPLISFVNWDAIPGVAHAAFGGWGVTALGVICILQYVVYLQRTRANQDETTSAFDEIRSE
LDNIQKDHRITRLENRLLREFVSETDVDRAIRVLLNNLIPNTDRGFAVSLEISGKDISVG
QSRGLSREARKALTVDPDILARAAGGEPFVLEGPEFRSSHLAGSLTVADRRHIHRLFIVG
IESEDALSGLVVATHLFHAETADQRHFALLKQLVQRISELRRAALALESQRHELTRTNDI
LELRAITDTRFESPVDMIQEFMTALKGKTAASRAVLYISTTAEGVSRNSFVRCGTVANPN
VERQLCQAEDAIATQAHSTLTTQVFNRTDLLRHGIRSFLTHALAVPLVRKGATVGAICLS
RDSSDRFDDADIELAMWAADYLAGTILNALQHAQVEQRARTDGLTGMANRASFDEAIKKE
VLLANETDECCSLLLLDIDRFKVINDKFGHLVGDHVLRSAAQTVLVSLERLRTHDRVLAA
RYGGEEFAVLLPGVNETGAARMAEVIRTAISDHTFVFAGATIPTTVSIGVATLPKHAMDV
NQLIAAADGALYYAKESGRDRVAIARATDPRRGDAPVTQPGASQSL
>A0A2C9EG13|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MHRGQPVLPAGRRQPGVVRGQPGFRGAQWGEDSSQRAAAFPSSSGGPMKLFKPNARPTLR
SVIGRGHLIVALLAISMASLSLTFLGVLALRVYADHNLHLIARSISYTVEAAVVFNDSVV
ATEALALIASTEEVADAKVYDSQGQLLASWQRPESGFLTNLEMHVASAFLEKPISLPILH
QGREIGTINVTGHGGSLLRFLLSGLVGIVLCIALSAWLALYLARRQLRGITGPLRSLADV
AHAARRERAFDQRVPPAEIAELDNLGNDFNALLDELEAWQTHLQSENETLAHQASHDSLT
GLPNRAFFEGRLIRALRSANKLNERMAVLFLDSDRFKEINDNFGHAAGDAVLVAVATRIR
AQLREDDLVARLGGDEFAVLLTPLHRVEDAQRIADKIISSMEVPIQLPGSLSILTSLSIG
IAVYPDHGATPGSLLNAADAAMYQAKRGSRGGQHTVGAELPIVQVQNRS
>A0A2C9EFS4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MTEPEDPSRERLKHHFAQRVIHQARQILEIWQRLQRSEWSTTDMSELCEANLRLLRFAER
FEQPEHTQLARSISQSLEAVDANRGRLSSNLITDLNRLMQRLSRTGLRHGDQLEQTFLPP
LRKPIYVMLQDHDRAERLAKQLEFFGLSAQSLDSIPAFRSSMVERLPAAIVIDVDFCGAG
MGLTLAAEAQVGLEQKLPLLFFSLHETDTPTRLAAVRAGGQEFLTGTLEASSLLEKIEVL
TCVAQYEPYKVLIIDDSRAQALHTERLLNSAGIVTRTLIEPIQAMAELADFQPDLIILDM
YMPACTGTELAKVIRHNDRYVSVPIIYLSAEDDLDKQLDAMSEGGDDFLTKPIKPRHLIT
TVRNRAARARNLKARMVRDSLTGLYNHTHILQLLEDCSFRARREGKPLSFAMLDIDHFKR
VNDSHGHPMGDRVIKSLALFLKQRLRKTDFIGRYGGEEFAIVMPDTDQDAACKVLDEIRQ
RFAEIHYPAQPQDLWCTFSAGVVEMQEDSDSLMMASQADEALYRAKHGGRNRVQAARSSQ
SAIFSSESTDSVITL
>A0A1R4B2C4|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MMNSITRKLTVLSVSSVLLVGFILFSLGKIWQEQNHTLDQLGRLAEIQRNVNGLRGQLWV
FLQYGDRNSLEQVAFEQKNLDKRLKSSQGQGIKLANLMKMNSSLDVLLEQERRLVSSVEA
QSMKDNKRHFVGSSELLHARYNMLIQNMTDELGYREKTILSKSEKNQKIALISTLIQQLI
LSILVCGFAFFIRHHFKRGFALLSQGISDLAKGNLDSRLSYHNVDSEFKTLIQFFNQMKR
SLQDTTYSKDELAQEVARQTSKLNKQKQQLQFLSEKDTLTGTLNRRAFKDYFQRSLINAQ
RTQVKSAILFIDLDKFKQVNDKYGHDAGDKVLCTIAKRLQNNLRESDFFARFGGDEFLVC
LDLLNSYDGVHDKALQLSEVLHEPISIGDQKEVHVESSIGIALYPLQADNVDDLINLADQ
AMYNAKFSIDYGIYCQATDNVNEIKPG
>A0A4R8SNN0|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MSSHVMSFRNRAEQIYTVNTETLEGIRLLRPVWLLTAICAPGIGAAAVTLAFAGMSTVPL
VCLAISIPAFAWGIRYALKKPITYAESIAYILYCDVAITVGVCVVTETGIAFLKLVWLVA
ANTYAFAFHGRLAMAVQAAVTALATGLTIGGAVIRGDSSTPALITTVATVILVNAVAAWA
IYLGMAQFAKVARDKDRLARQDELTGLLNRRGLQQACANWSGDATGKHAVVAVIDLNGFK
SINDKQGHHAGDQVLQQTAQLLQLLAGPDTWLVRLGGDEFGVVTVVDGNRVLDYQRAVED
ALADDIAQVDASVGVASEELSRTDGSAPVSLAVVVADLLIKADSAMYAAKRYATSQGVNL
IERRTSL
>A0A1R4B5D9|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MPQKNTLSDQDLAVLSRGFEYLDQATVITSLDRQILGVNLKACELFGYQVSELVHKSTQI
FYATIEEYERLGKERYNGLNKSTNTATNVQYTTKSGKSFVGKTYGGIVYDDNGNPSCIVT
LISDVTTQVATEEALNRLHRITSSRQLSFEQRVHAVLELGTRLFGLPIGIFSKVTESEYV
VQQAVHPENALEKGMTFDLAGTYCSHVYNANDVQGFNHVSNSSIACHPCFKNFGLEAYLG
APIFVDGGRFGTLNFSSPEPCRPFIQQDIELVKLFSAWVGHEIGRNSDISALEHAHKEME
RIANTDDLTGLVNRRYIEVTLTQMIQHSAALEIPLCVAIIDFDRFKQVNDTYGHSIGDQT
LKTHSELMQANCRGTDIYGRWGGEEFIAILPNTSLKSAVSSLERFRSKAESHIIDASIPE
LIVTASIGVTELRPDDNLDSIVNRADALLYLAKQNGRNQIQHEK
>A0A8F9XP20|diguanylate cyclase|EC 2.7.7.65|Bacillus sp. 7D3|TrEMBL
MLKELFLNLTILITFNYLFTLLFKESLSHKEDRPMFQLLKGTACGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFMIIVAGRILINFNASAIFSIAAVGMIAILSVAVL
RGKKPDRKKAFVMLLFSNVIFTLTMLLLMPEQQPAMALVYYWLISTVGGMLSLYIIKHEA
DARLLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRASQSASSQLALIYFDIDHFKQIN
DQYGHYEGDQVLKELGARLRFLISGSDTSARIGGEEFAVLIPNCTYKKGLHLAEEIRQAI
DGNPILLTSGDTIPVTVSLGIAHYPTNTADPQTLPLIADRLLYKAKTSGRNQVCSTEKKE
>A0A1V5MVH2|diguanylate cyclase|EC 2.7.7.65|Bacteroidetes bacterium ADurb.Bin416|TrEMBL
MNVLADIRRITDTDWYLITKTDKAELYEQLHKIQVFVSMISAFLLMLLWVSLAWLYKVRQ
QKMYKELVAKNLALKRSQEEFAATLYSIGDGVITTDDRGHLVRLNSAAEKMTGWLEKEAI
GLPIETIFTLVNEETNAPEPNPVRLILVDDPP
>A0A3B7PRJ0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. WCHAc010034|TrEMBL
MNTESIDVLAQQWESICSDYSAGVLSDTFQFIQAHSEALVIEFYKNMMLEKEASYFLSDD
IVQNRLTKTLNQWLIECFNAPFQRNFAELTEKQQTVGKVHARIGIPSWLIMRGVREIEKK
VFSLQSEALQPESYAFSMTCYMFQVLGFSSEIMCRSYEVNVEKSNDIKHTYRLFSAMQDV
AVQKDKQRGSLLDWENELMFKVFSDQHKFTHPALSKSEFGLWFIHKAAYAFTGSEQVDEI
IARIYEVDQLNQTVLECEEKERTIQLIQNVRGKNREIQHLIDQLFQVAEYIDSGNDALTQ
LLNRRYLDTIVSREINFSRKNRAPLSLLAIDADYFKRINDRHGHAAGDLALQFIGEVLLE
CVRGSDYAFRIGGEEFLLLLVDSDLSRAQEIAENIRRRVQETAIRTALGSSFNFTVSIGC
SLYDGHPDYQRFLDAADAALYAAKNNGRNNVYLSR
>I6DXG2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>I6EEH2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7I7G069|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIQTPLAFDVLQKAVSRFSSVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A7H8UF73|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHDTYVVKQSFLQWLHKRSNPLLVVNLCFIVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQFSVNKMLYFRHSMLDALETPLAFGVLQDAVKRFDRVRRSPVWQIAVDK
KRTLPINGVSDAFVEKTTLLTRDDDYLNNELSAALEVGYLLRLASTNSRHEERVLYVSRA
GFFLETDTPAHHGDIAQRYYHLVTQPWFTQQTDRENRARAVRWFISPPSAFAGKQPLITA
SVPVYYHHVWYGVVAMDFTFATMRQLLVEAMDDHTEGEYQLYDSRLNMLATTETPAEEVN
HFDERELAQIAHAIELDTEGGIRLGSRFISWARLDHFDGLVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGALFERAKVLA
KQCEQQSLPFSIIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTVRAGDIAGRVGGEE
FCVVLPGLTLEEAAEVAERIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFEQLQ
SAADARLYEAKQSGRNRVIWQDQDKK
>A0A240EJM6|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MIIIDIDDFKNINDTYGHIQGDKVIKVVANTLRSLLNNDYVLARIGGEEFALAYVYQGFE
YSYQLSQNICRSVREAKVNDACTSPVTVSVGCAIYEAATEFETLYEADKLMYAAKKQGKN
RAVVELLSSREKRMSVID
>A0A1W6K431|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MNTPQHPDLGASLEQSRSGLRDTHRRSLMRALFLVTASALVVFGCLQILNGYIWLATGEL
IASLILFFGVTRINRTPRLQVWIYSYLVTGFSFALMIMLVPEASVSAFVWVLMIPVLAYL
LLGKKECFLLSAPFVVAGCVTYYFHLEFVADAGGVIDLLNMVLCAILMLSFIHLYEARRE
EAEQKLFTLAQTDALTGLANRANFQSTLARTIAECARSGSGFALVIMDIDHFKVVNDTMG
HDAGDHVLQNIGKQLTERLRTTDAVGRLGGEEFGLILRDVKLEDSFQLMDELRQRIADSE
LPYGDALIRVTASFGIAHYPDHAIEAESLFRIADRCLFSSKRAGRNRVARAGLSPVKGPL
ATART
>A0A330G6Q9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHDTFVVRQSFLQWLHKRSNPGLIVNLCFLFVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRELQNSVDRMLFFRQGMGDALQTPLAFDVLKDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDADRIGHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTRDERTITA
SVPIYYDRYWYGVVAMDFTLSTMQQLLAEATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKILT
ETCRQQSLPVSVIQLDLDHFKNVNDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVADRIRCRINSKEILVKKSTTLRISASLGVSSAEEAGLYDFEQLQ
SIADTRLYQAKQRGRNRVVWRDQDRK
>A0A7Z1AEM7|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MNNHHWLLALLALLLLVPFLETRAFEQQAPQSVILENGFSYADLTDKIQILIDPQQQLGF
KAISSTGRQRDFRLNSGKIGFTDAAVWIRFSLESRFTTKQPVILEIDFPLIDKIEFYEMD
GKGNYRLRFGGDSIPFNLREIEFRNTLFKIELEPGQTATYYMKFTSRGPIQLPLRIWNYQ
AFTEHSTSSHLWHGLYFGAILMLIVASVVGYNLFRASFFLWYAYYLSCYGLLNFTLVGFA
GQFLWPETPILQQYATSLLVNLVIIGAVVFSGKLLDIRKYSRAYFLIFRTLIILALLGIA
ISLAGRLEIANRIASLSGMALVPILISAAIVTYRKGNFAARYFLVAWGVFLIFVFISGLY
YWGMLPYGFVTAHALQIGSVFEVTMLGVATADRVRLLNREKEEADRLANKYLVLLNEKLE
DLVHERTVELEESNRKLHELATHDSLTLLLNHNAIIHALESAISAVERHRQPLSIAMVDI
DRFKQINDRFGHQVGDDVLVAIANTFTSSLRGYDIIGRYGGEEFLLILPQTNTEDAGELI
ERLRQSIADLSFTGTQGKRVTISVGMIAYLHGIKIDADAMIRCADDALYRAKANGRDRIE
WGNCTTILNKTGCAGSEDGQR
>A0A8J7SMZ9|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MSDEPSLILLDPLGGVADEIDGLLRPFGYRVTAIADATALGACVGRDSPSHVIVRLRGGK
EDGAVLDAVRDLAAASGPAVTVIADDASMRARIEAVRAGVEAYLTPPLDALGLVERLESL
KRGVRADPYRVMIVDDDVTMAKYYDAVLRAAGMQVMVLNDPMKVIRYLADFRPELILMDH
YMPEIQGRELAAVIRQEAAFDSIPIVFLSAEDDATIQQRVMGIGGDDFLTKSIRADNLVS
AVANRARRFRALRATMLRDSLTGLLNHTAMKERLAADLARMKRTDRPLTLCILDLDHFKL
VNDTYGHPAGDRVLRALAHLLKQRLRVSDVIGRYGGEEFAIALPDTSVEQALPVLDEIRV
AFAEMPQHHEGGTFHVTFSAGLAAFPRSEDSARLTDAADRALYRAKAAGRDRVVPAGAVE
YGSRDAMHDHDGMRAL
>A0A1V4W0U1|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin117|TrEMBL
MDTYQQILNIVEFLPDATFVINRDKKVLYWNRAIEEMTGMPKENIIGKGDYIYGVAFYGK
PVPLLIDFIFSDNKDIEKKFDFIERKGETLFAELFVQSVYKGKGAYLWMKASPLYDNDGN
LVGAIESIRDITKHKREEEEIRQYRNHLEELVIKLRAANEHLQKEIIERKQIEEALRESE
ERYRQLVELSPDAIFLHSKDRLEFLNEAAAKLIGAESPEEAIGMPAIDLIEPDYREVVGE
KWRLVLEEGKTVPLREEKLIQFDGTVIDIEVMTAPLTFQGEPKILAVVRDITERKRVEKA
LKESHDRFLTVLDSLDTGVYVIDMETHEILFTNQCTREQIGAVEGKICWQTIQNGQSGPC
DFCTNNKLLTPEGEPTGLYVWEFQNTRNGKWVECRDRAIRWIDGRMVRLEIATDITERRR
ARELIEAERKKLFTALQITEERYQQIVETANEGIWIIDSNEKITFTNKKLNELFGYTNEE
MIGRSIKSLMGEEYRYKFERDAEAKYRRKDGTELWVIVSSSRLYDHDGRFVGDLGMLTDI
TLRKQAENALKEREEQLRLIIENLHDAITKIDKNGKFEYLSPSIKNITGYAPDERMGKSA
FELVHPDDLDRVIATYETSIKTSSSGKAEYRLRHADGHYIWLETTGNLLLDECGKFIGAT
MILRDITGRKLAEEKLRDAHQQLIDVIEFLPDQIFVIDKEKKIIAWNRAIEDATGISKEE
VLGKEDNTFAIKVYGESRPLLIDFTFDNNPEIKSEYVSKYSYFKKIDNLLHAETYIPSLF
NGKGAHIWITAAPLFDGEGNQVGAIETARDITERKQMEEKLKYLSMRDSLTGLYNRTYFD
EEINRLKGGRQPPLGIIVCDVDGLKLINDTMGHEAGNTLLVSTANLIKSCFRSGDMIARI
GGDEFVVLLPCTDRHAVESACHRIREIIADYNIANPELPLSLSIGFAISDNQTKSPNELF
AEADLNMYREKLSHSQSTRSIIVKTLKKTLEVRDFATEGHAERMQKLVVHLATACGLPDY
RLNDMSLFALFHDLGKIGIPDMILFKPGPLNEEEHLIINKHCEIGYNIANCVPDLIPIAD
WILKHHEWVNGCGYPLGLRGEEIPLECRILAIVDAYDAMTSDRPYRKAMNQDEAMAELIR
CSGTQFDPRIVQKFVEISENQLL
>A0A8I1YZZ7|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MRSLFSSGRPFRLVPYFFLLSLLLMAGATALMAGNLRHYSGEQLLKLEKSRAASLVQIFE
NSLWTDFRPLLPLARDPAKLKQVAGQPRLREAVIRLMRGTDVIRVKMYALNGITLFSTDD
SQIGEDESDDDGFRSAAAGTPASELAHNHSIDAFERTLTDRDIISTYVPVHDPAGKIEGV
LEIYLDATPFVADSDRQLSWVTLAICALMAVLFVAQMLVVRLAGRIIDRQAAALSETNRE
LDSRVAARTWELANANARLEDEIQERRRAEERLDHLAHHDPLTGLPNRLLFQKRLSRALS
VPDLPPYKLAMLFIDLDRFKDVNDTLGHYIGDQLLNAVAARLAGSIRAEDMLARLGGDEF
ICVLESIENRDMAADVAGKLLALFRQPFCINGNDLYLSASIGISFAGNDGSDVDTLLRHA
DIAMYSAKNTVLRCPRTPSSGWCWNDNCARRWTTTKSPSTTNRKSTRSPASWSARRRWRA
GGIPYLAWCRRRDSFRSRKNAA
>A0A564SNA1|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A6N2Y4J0|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MQKIFRKYIIIIMSISLASVLLINFFLSTDSLQARTLETFNLKINQVIQTIENNRTELVS
LKSSLDEDYLTRAKAFAYVIEKNPNIIESVTELQNLATLLDVDELHVSDSEGLIAYSSVP
KYVGLDFHNGEQMRGFLPILESDDPDEYVIQDAQPNTAEGKIMKYVGVARKDKKGLVQVG
LEPTRLLEAQQRNTYSYIFSRFPTNEGEQLFAINKTTNELIASTNDLDDKEASYYTYDNL
KDCQSGTFKDIGNKTENFFVTREYDNILIGATVPKDILYKNRSSDLLLIGAYLIAIEIVI
VVSINVILNKKVLKGIHSVLNDLNRIKNGDLNTVVKADDNQELIDLSSGINSMVNSVVNS
ADRISKIISIIDIPLAAFEYQNDTKQLFATARLKELLHLSDEEANQMYLDPKQLLKKLQI
IISNPIEGESDVYCLEKDTFIKIRLVKDENGFYGTVNDVSSDILKKKQIQYEKDHDHLTG
LLLYPSFKREVTLVINNNNYNHLYAAIMVDLDSFKHINDTYGHDFGDHYLKRLTYALNKL
SKSNCLIARRSGDEFCLFIYNYQDKNTIINQLNKLWSYFKEELIELPDHSYQSIKVSGGF
VCSSGLNNTIEELMKKSDKALYEAKNHYKGHFIEYKGK
>A0A1Y0HP81|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MQKEYIHILECVGHGVWEWDPIGNRITLSPQWVSMLGYEYETFQQTKDMWMSLIHPEDLN
YCLNELTSLLSGRIKHYRHQHRMLCQDGSYKWVLDQAKVVAYNPHGYPSKVVGTHTDIHE
LRTTVEMYKQQRK
>A0A3S4X601|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MSVERQRLPATVLLVNVFLLAYLLSLFGIFTRPLGSLSLFWPVNAILLGLMLRKPGYATM
LGWIGTYLGMIAADFSAGGNWPLALWLNACNMALIATGYAVMSMLPKSQRRMGKPQAILY
MFTACLLGAALSATLSVLRTDSQYNNTLIIAWMSWFSEQFSTNLLILPVVLAAPRLKQLL
SLQFGWQLRSSLPLLALLLSLALSVYIGGPGAIAFPIPALLWCAVRYHLFTVTLLTFLTG
VTEIVSISANLMLYETPGARGAVMDSLMSARLGIAMLVMGPLILSSSIAVSRKLLRRLEH
SANHDFLTGTLARSALTRKGREMLEQKQRTKEAVSLLLIDIDHFKLINDTHGHAIGDHVL
AAFAHILRRELRHDQLFGRLGGKSLPLCCRERWGRRRWPWGNICAGG
>A0A609II35|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMKEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DCVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F4ZYK5|diguanylate cyclase|EC 2.7.7.65|Modestobacter sp. L9-4|TrEMBL
MGATVTPTGELTRAIVDATTALVMLIGEDGRILLANPAMQAFTGQPESELLGRLFWEVYV
TPEDIPRARQAVGAALIGGASFLDEGTWFRGDGVRRRVSMQNSVVTDETGRPHGIAVVAI
DVTEQRQREALVQRRATTDALTGTWNRGVLFDALQKQLAPGIGPGCALLFCDIDHFKAVN
DQHGHARGDQLLVEVASRLLELAGPDDLVARFGGDEFVVLVPDVAASELAALVDRARAGM
GLPLQGATASLPFSVSIGGAHGRPGDDPDHVLAMADQSMYRRKRRRT
>A0A0M7F283|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MPATLLEWSVPAAILMCAIGLCAARFIGFNTLRWGCALASLGAGYAIMLVQASALSPYKQ
VVEDAFILGGVILACRALQSRRRSQVPPYFDAAVLLASTAMVVVSVVLFASAKLETFFVQ
ACCALVTWRATLSFARHAVTTSDRVLTAAFLFISLVLTGQCILYIAAPIPPLSTGEWRTS
VWGILIQYTGLLGSIVLTFAVFIATSYDAIEKYRRHAHTDALTGLLNRQGLDSLLASGRA
FSDAATPTALIMADIDNFKRINDVFGHAFGDMVLARFGALLRPLTDTRIHAARLGGEEFL
LLLPTASLENATAIAEEIRASFVAQRWTPQVPDSCFTASMGVTAVQAGEPFASALKRADD
LLYEAKRRGRNCTVAGMAPAEAGHGRHAPGDNASTQACCAQA
>A0A0U5MQC5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MKSPDTLDVAAHCARAALAMMERHKVPPHPENYAIWYAYVAGRNPELTAAIDAILASGKK
FTTKVNDELYERFAVFPQDTAELREVGQRVEEAVGRVLEYLSNANQGTSNYGAALEDFSG
KLADGPSAAGLSELISGILSETKVMAELNRQLEQRLENSSNEIARLRNHLDDLKREASTD
ALTQLANRKLFDHSLNLAVLDARASDAPLSLLMIDIDHFKQFNDTYGHQLGDQVLKLVAR
SLTEIAQAKDTAARYGGEEFAVILPATSLDKSVEVAEAIRSQVSTKRLTNRRTGQVLGQV
TLSIGAAVLRPDDAPEVLVHRADEAMYLAKRDGRNRVKSEAHLENPLTDAAK
>A0A1T1JBS0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. MF4642|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETILMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A7L7IIW0|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00175|TrEMBL
MQRDTYVVKQTFLQWLRKRSNPRLIVNLCFLVVLVFSTLLTWREVVVLEGAYVSSQHNHL
ETVATALDRQLQFSVDKLLFFRHGMRDALQLPLAFGVLHEAVQRFEDLRNIPSWQLAVDK
DRTLPINGVSDAFVEKTTLLNRDDDLLNNELSAALEVGYLLRLGSSSTRQEERVVYVSRA
GFYLSTDTVSHTEDIVPRYYQLVTQPWFVQQSERANRARAVRWFISPPSSWTGGEQAITA
SVPIYFDHYWYGVVAMDFSFSTMKRLLKDATSDQTEGEYQLYDTRLNLIATSAPTAGNIN
HFDERELAQMAYDIESDTEGGIRLGSRFVSWERLDHFDGVVLRVHTLHDGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYALQHTLQWQAWHDPLTRLNNRGALFERAKILA
KSCSQQSLPFSVIQIDLDHFKNINDRFGHQAGDRVLSHSAGLIVSALRTNDVAGRVGGEE
FCVVLPGIALEEAAEIAERIRSRINSKEILVKKSTTVRVSASLGVSCAQEKGNYDFEQLQ
SIADARLYLAKQGGRNQVVWDDQDKK
>A0A8I2CV55|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium|TrEMBL
MNEYIVDRTLELSPEFIKSNADIIPLLFQVSLLSDVEVRIEKISDLFLNFLGHVTPYDVA
FVYIWDPQDTWFCRGLQGEIPVDIEKGDIFTSAIRDMAKPILVPDVNLAGIKPDELPIHC
SSMIGLPIYRDTKVIGCLELFRKKDKSFSIDDLVLTKHLLLSSEKVLREVLSPERDFDDA
LDVRIDVPQRHILLDVLHQYEELAKRLGFPLSVAIIEIEDRDKFGLYQHIPEGIRTLKSL
AKRIQGCLRCYDKVLRYEELSFFVILPGCSSGDAVTALHKATQSLGADLADTMTIGVATL
PDDAQDAKGIIHDVHQTLSHARKKGIRLATYSQAGAMKKVNLSLELGIRKLLQAGPCMKA
LAELLHLVKIQCQADDISIRYDAPGNQICWDGHELGYLRQDGLPQDIFEWISSYITPAWA
VAAGFDSDIHDWYMGVLNTLSIMSDLRAGYPMGYSLKVSDQTYTLAKEMGMGDVLANQWA
ISSLVANIGYLGIPTTLFTKGDLTPFDKKKINTHPIITTRILKDVAVIDLDDDLLSFHHE
NFDGTGYPRGLSGQDIPISARAMRVVDTYNAITSPRLYRPHMKHKDALRELCAMSGKGLD
PEITSLYVDLIGS
>A0A7Z9CZQ1|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQACMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A3S9L5E5|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MSDKPQTPDDGARVLMQTAATRLKKAVPLMLKHQIPTTPTNYALWYAYVGEQQPALNQAM
NQAISQYQTCPPVTSELLYREHIADPIELDVRDMRQNLEAMASDLASQLQDTNLDATEFQ
QKIDANFTKLNRIENEGFTLEQVLVLVRSLVKESDAIRASTSYFTGQLSKAQQEIDALKS
RLAASEHDMLYDALTGCLNRRAFDTDLAGLLSQAPDGTCLIICDVDHFKAFNDNYGHQLG
DQVLKLVGKRLCDACRDGVKCYRYGGEEFALLVPGSNLRIARQLAEAIRRGVEKLTLKDR
RRDARIDNISASFGVAQWQPKMDSRALIEAADKLMYEAKRLGRNRVMPISG
>A0A5P9CLG2|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MKSLSPLRPTLGLRLCVHLGTLITLILISFAILVGEYKEQKRRILDNYSVSMESKVRSSI
GVYKKFSHYIYQQIVNNQEVLQLLEIAVAETGNKRDQARMKLYQLLKDNYQLLRAHNFRQ
LHFHFPNGDSFLRVHKPGKYGDNLFSIRESVRLANTQQRIVEGFEEGRIFNGYRFVYPIT
YGQQALGSVEVSLSMGSIIDLLVELYPKDDFQFIISQDAVDSKLFDDMKDHYIPSVLTDG
YYYDKAVFEKHLRDVNHRNLIDQAKTYSSKLKPLFDKKESFSQAVSIQGKDYIISFLSIK
NFKDQHVAYLISSSRDNLLGTLLQNYATYFILIIVVSLFYVWNIYSEFTHKKQLTYLSST
DFLTKLSNRNTFTENIQFEHAKSTSFNTTFSVILFDIDHFKKINDELGHNAGDDCLKELS
ELVSKKVRHTDTLARWGGEEFIILLPETPEESALKVAEAIREAIESNAFSLNRTVTVSLG
VAEITPDDGNVDMVIARADEALYASKEAGRNKAKAWSSLKGNN
>A0A5P9CPZ1|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MLKQQLSENYVNQIQISQTLAMLQTDMGYLGFIHHFKNYVIRRDDQYFQEAKQSYRNVKQ
HVQKLYFLVSDVSFLNDVSIVESTADEYYEKLLMAKEKGTRLSTAELDKLVKVDDIPALN
AMLRTHHIVLPEVNRILDVTEYQVSKLTASMWIFNIVLVPIVFFSTWFILRVVRKTNVYT
EELGEIFNLSPDGILYIDNEGNILGANKMVSEIFEYTNKELKRLKVEDLIDPNIKDKHIQ
LRHQFQSQQQSRVMTDRKQRIQGKTKSQIDVEVQIAISSTIVDGKPRTICVIRDMREHNE
LKETAEIDYLTNLYNRRSIDKIVFNEITRADRQKSSVSLILIDLDNFKQINDEKGHDAGD
QALSQVARFLQEHTRNYDSVCRWGGDEFVIVSPGMSEKDVANYANRLIESFQHSPASDGL
LNFSIGISTHTPKNPYDADSLFRHADQALYHSKSAGKGQATHINDMDQSEVKSKPVNL
>A0A6N1BHA9|diguanylate cyclase|EC 2.7.7.65|Cupriavidus gilardii|TrEMBL
MTSDPEPTLPALPRWQRVSLASALFFLLAVAGIALTRYPGNAAIVWLATAFGAGVTLHQP
PRERAWMLAGMLVAGIAANAMFGDPWWLALVLGASNIAEILFVAWLAPSISGGIGRASAV
PLARFALMLGATCTLAPVIGATIGAAAISIAYGQPFAGIWSTWWSADAMGMLMLVPLSVT
YSRERLRDTFPRTRLPRVAGLLLLTATVGGLAVVQTHDPFGVLSLPLVVAALFTNPFATA
LLTLLSMLVTVMLGLAAAQAGLVDAPQFLTHAMKLSTSLILVFPVCIAYLSEQNRRDRSE
LRGSERRFRQAMHHSAIGMALVSVDGRWQQVNRAICELFGYSATELSRIPFQQITHPDDL
AADLAQLDRLVAGDIDSYRMEKRYRRKDGNFIWTLLAVSLVRDEASGAPLHFIAQVEDIH
EHKLAQQRLEALSRRTELAVEAGRVGIWEWDIAAGTLSWDRRMHALHGTAAADGAPDLDG
WIALVHPDDVARARHEMRQAVKGAQPFDTEYRILRPDGQVRHIRAMAVVSRADDGTALSM
VGTNWDITEHRRLTEALFEEKERLHITLRSIGDAVICTDASLRITFINPIAEQLTGWTMA
EADGRPLATVFHVVDETSGQPIACPVAKCLQTLRPVYLEDGAVLISRHGERHDVQDSAAP
VLTPRGDVIGAVLVFQDITAARALQRKLAHSAMHDALTGLPNRIWFEQRLREACESAREF
DQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRSQVRPNDLLARLGGDEFALLLR
NCSVDQGERVCLKVIDAIRARRFPWEGRVYDVGASVGITAIDREAPPLGELMSRADVACY
AAKAAGRNRVSVYRRDESDARRHHRELQVAAGIHSALEANRFRLFAQEIRALAPGSGSTP
PAALPASSPASPPASHIEILVRMVDEHGSLVMPGAFIPAAERYDLMGHVDRWVIQHVLRD
FGARLLAVPGLSVSINLSANSLGEPFLLPFLHAELSNSVLPASRIRLEITETALINNMAA
ANRLVAEMRKAGCTMALDDFGAGLSSFAYLKQFPVDYLKIDGSFIRHLASSAVDREIVSS
INDIGHRLGIHTVAESVEDEATLDVLREIGVDYAQGYAIGRPMPLEDYLARCASGTPGET
AQRQPR
>A0A645FRV8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MYAGEKLGVNEYLGLRPDGSTFAMETSSELLMSPDKRTIQLISVVRDVSERRQLEQELVQ
KGQDLQHLNEVLRSSSLTDSLTGLHNRRYFDEAFAKAYEEARHGETSLALLIIDLDRFKL
VNDTFGHAAGDSVLVRIARAIQEKAGPETLLARWGGEEFVLLSKGMSREQVVQYAQQLRV
HLADLAHEQVGQITVSIGVATYQGSENVHELFKRADDALYQAKQAGRNCVFSV
>U5Q8A7|diguanylate cyclase|EC 2.7.7.65|Bacteroidales bacterium CF|TrEMBL
MEVNNPDYTILIVDDVDANVLLLKLLISKAGYKTMTAFNGRDALDAVEKQKPDLILLDIM
MPIMDGHEVAKKLKERPEYADIPIIFLSALNSTEDIVQGFRFGAADYVSKPFNKDELLTR
INHQISLIEAKRIITRQTEELRKTILGRDKLYSVIAHDLRAPIASIRMVMEVLISEVKKE
SIGDDMFELLNMANRLTDDSFSLLDNLLKWTKSQTGRLNTVFQDNVDIMNMITGVVEVQR
GVASLKNVRLNLLGSTNRSARIDIDMAKTSLRNLISNAIKFSYENSEIDVGIEEKEDKVL
VYVRDHGTGISEDDQEKLFKPDSHFTSFGTDNEEGSGLGLLLCNEFVMRNGGTLRFTSKE
GAGSTFTFDIPTIAKNE
>A0A822PPM4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSRKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>E6WNA7|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. (strain At-9b)|TrEMBL
MQEEIKQYISVILKEWQPLRAELPQDVIVILRNIAEEQSDNLAHRFYESLFKDPAISRHL
SYELVEEQLSRSLSKWVKAILTQDESQFEVLAQQQYHVGGVHARIGIPVEFVQRGARQLK
YGIYDYVTDNNITTALGLQVMHYAAMAIDIAIEMMSHAYAMSHYRATRNEEAYRMHVLMN
NAYQEQGKQQSALSSWENSVIYGLVSGVHQTEPLIKIAESNFGLWFRHKCARQFGENDQI
QQIRQLMTTIDEKMAHLDITAVIPVEKMQDLLRTIHACCQKIGTYMEMLFNDVSHMQDGK
DALTNLLNKRYLPIVLKHEVSLAMENHLPLSVAIIDVDFFKKVNDEWGHSVGDRALTHIA
NLLSDNIRASDYVFRYGGEEFMIVLVEAGRSEAYTLLERIRRIVSSTPFEAVSGKILPLT
VSIGYTVHDGHPDYNQLLNRADVALYQAKRNGRNRIEQQ
>E1J7F9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 124-1|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSEN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A0J1FNM0|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MLPAQSKTYRLKPEDVFGLLQEINHQENLEDALKLLAKRGLDFFNSTMAGIWLFEERKFH
SLTISTLTEQQERFLKHSFLSSDLRNFFKGKIESDAFFEPSITLHEIDEQGYEHDFGELK
KGYRFTEWSENLREFAIRRILCVPLVHYGQFFGLLALFSADPSAFDENSVYWLEQLMPLI
SSNVYEQQLRLAALDREQALSLLLRGTEILVKAVSEDQLLAEAGEMAMEILYLEAGFFHM
EQEGNWIIRSPFGRLKQLEKVWQEWMNRDKQIHFPAGYVPRSTPRLRVLEESDQRDMPYP
VKRIYIHPIIAHRGIVGELWLMDSGVRNLEQTQEILSAFVRILSMSLETIRQRLELRRLA
TTDCLTGILNRQGFEQRMLGEMANTLRRGTTFQFLLLDLDGFKYLNDTQGHPAGDLALVH
VAQNLQKSVRLGDIVARTGGDEFAVVLTDLKAGTDAIKIIERLKKNLDLEKFGLGITIGV
AEFPTESQDYETLYKVSDRRLYIGKQNGKGQIIVKD
>A0A7W5PPV0|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK275|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAADGYEALAICDRNQVDLVLLDIMMPGID
GFEVCERLKANPKTAHIPVVMVTALDQSADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRVRAETAHTMGMDELMRSGDGRSDEAGQVLLVDSRANSQERIIKTLKPVAD
VLAISDPQAALFEAAESAFELVIVNANFDDYDPLRLCSQFRSLERTRFLPILIITEQGAD
EMVIRALDLGVNDYIVRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
SNRRYLDNHLNVLFNRSMARGRPLSILITDIDRFKQVNDTYGHDGGDQVLKEFANRVRST
VRGADLACRYGGEEFVVVMPDTSPEVAAAVAERLRAAIETTPFLLKSSGETLNITASFGI
SSRIASVITPDQLMKQADLALYEAKNTGRNRVVASAA
>A0A0H5V4C0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MKVLPRVLLGLVAVTIVTVLLYWQFGSAKRVLIEPQHYAYFTTNDQTAGGTSTSALSLNG
NTAKVDCELNASRYAWPYCGISIHLNPDPQRGLDLSDIHTIRLNVDLQGPAAEPAAMRLY
LRNFNPIYSQLDDEYTHKYNGLEFVPGVGKGVIDIPIRSLQVMTWWLVDNRIAIEHSAPE
FSNVNKIEFATGSASPLGQYQLTLHQVELIGDYVAGEKLFLAMLIMWAVAGAWLSALEIR
RNRREVLRARMRQEHLQRLNHSLHEQNIKFVEMAHRDALTGAINRHGIRDWLQDQARLVR
WQLNHVSVLFIDIDYFKQVNDVYGHSLGDDLLREFALVISREIRESDKLVRWGGEEFVVF
CAQTTLEQAIELAERLRAKIADHSWIHGGAITCSIGIAQMGDERITETVSRADEALYRAK
RLGRNRIEVHYGLMAKSSDGEKG
>A0A3Z3I1F1|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A085R667|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MINSLNRKMTLLFIASLLLVGFIAFSLLNLDQRQQQTNAELDTILEIQNSIAMLRSQLWV
FLQYNDAHSLEQVYRAQQVLAGQLEMETVFGQHLAGIQRMNNSLAGLLEQERYMAEESGI
TKLVDGIGTYELLHSRYNILVQNMNEELAYFQRQVMEESINNQRYLLLTTMAHLLLFSSV
VCGIALVVLRRFRHGCKTLQEGIEQMAKGDLASRISTQNNEQEFVQLTQFFNQMKASLQS
TTVTKDELQAEVARKTAKLERQKAELRFLSERDSLTGILNRRAFKQQLSHALIKAKRSNM
KLALLFFDLDKFKEINDTKGHEVGDLVLQEIAQRLKGSIRESDFCGRLGGDEFVVCLDLL
QDHSGVINKAYQMLEKLQKPLQLNQESLEIGVSIGVALYPEQATQVPELLRIADEAMYTA
KHQSGNTVYCAHQDKHDHTSLVS
>A0A2T9Q6C4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A174F735|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLE
ITGNQNDELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYYTSEAEIKEILKSLSREKER
LNSCENQLPIDYACGWALSSDDMACTMQMLLDDADAYMYKNKQLCKKYN
>A0A3M3Y5H4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLHIPTLLIVAVFVFCLMGLLTAHAWSRGREPTLGYLSIMLLLASLGTGLIVVRGMGMDF
VALIIGNVVLLLSAAMNWTAMRAFVQNTPSVPGIFAGAGLWLLMCLVPPFYASLSARVTL
YSLLAAGYGVLSALELWRKRDSLEVAYVPALVLTLWHTGFYAIRAFTDPGLPIKSAQQSG
SEGVPFFSFMLFESMLYAIGIAYVTLAMVKERAELRFKAAAFSDALTGVGNRRAFMLTGD
KLLADSARRRQCVSLLLCDLDHFKRLNDTFGHPMGDQALIAFSRVTEATLRSSDVFARIG
GEEFACLLADSDEAGAFEVAERIRQAFAQLDLLTPGFLSVSIGIVTTDAAGYDLSHLLSQ
ADQRLYQAKSRGRNRVQGMATA
>A0A655YM16|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDYRTVPQQWQSIKKAREIKQTFVSGPVDLVQGGRALVIREPIFYDPPKDTRYWGVLSVV
MDWDSLLSATSIYSFGEHFQVAIRGLDSRGSEGDVFFGEPRVFEHAFAQENVYFPYGSWR
IAVAEKQDLLQQLSWYTRNAVRLLGYSVLLVLMAGFGVIMRLYQVAEERALHDPLTHLPN
RRYFIYTIEHYFENAKRSHSEGNFALLNIDIDRFKSINDSHGHSAGDKVLVACAERIKSS
LRVSDLVARIGGDEFLVLIPRIHREQDVLKVSDNILKRISETPIVYDDKLIHVRVSIGYA
LYDQSFATPDEMFKLADERMYTAKRRQNPLYRF
>A0A109LF92|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAPLPSPVKQANPMHSLGQDQGHLIEEQVRTDRLHQLFRQSFSAIFGSYLGAVMLCWLCW
DRFDQQVILVWLVLLAGSSLVRLHLFVQWFRCPDAGRTPARWERHYWVTLMLSAGIWGGG
ALAVMPVDDRLSQVLVMLFTVGMSVSAVSCYSAYRYMTLGSMALVLLPCTVWMLFQPSPM
QVGVALAVLVFASFVVGATRKLSDALEKAFRLTRQMERAHHISTRAAQTDELTGLMNRRA
FYEQAQLLYAQCLREQQPLCALMMDMDHFKAINDTYGHQAGDQVLRQIGAVISASFRQTD
IYGRLGGEEFAVLLPNTSLETARSIAEELIQTIHDLPADPVQGVSASLGVASTCTQPLDL
NALMNSADKALYQAKASGRNQVAVVD
>A0A1C6IAM3|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MFTSDTAKYKIIGICTSCVQSDYVRDIVSSISRKGVKEGYKVLLFNTFCDLYHNISYNHG
EASIFDLINYDILDVLIIMPEAIKRDSISNEISKRAHEHGVPVICVDSTMDNCCSVTFNY
SDVFEKIVRHVIEFHGCRRVNFIAGVKGNAFSEERIEAYKKVLAENGIEFEPERLGYGDF
WDMPTKGVLEKFLESSLEFPQAIICANDAMAIAACSILRERGIKVPEDVIVTGFDGIELE
QYNSPRLTTAAVDNDVLGEKIINAIDHMMNGVPLPEKIEVSYTMRISQSCGCKKIDPREV
GDKILELYHRMNNSDGHEQHMFSYLAKSVECHTVEEMAKVMARSGDYYSWVCTNSDFLSN
TRQRERFNNSFTKHMRVFMQTFDNKYKTGEVFDTKDLLPDMEQVLGRHNCLMFSPLHFQD
EVIGYAANSFSPIYFLFQNTRRFINNTNQIMESFKNRQRLERANAELARIHMLDPMTGIY
NRRGFYKNVRKLISKAEKQGVGVWVFSIDMDNLKKINDLYGHNEGDKAIKAVASLMTKCT
AEGGICSRFGGDEFVAVIAETDGADSFYEKVSRSIAEYNRRSKSPYDVSISCGYKAGKPK
TLKEIDDLMKESDREMYTQKRKHHSRRD
>A0A0I5BNU0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGISTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNPRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHC
>A0A0I0E539|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSG
>A0A5M9IKL3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MSRVSALRFSHFLPSLLLLLAGLSAAYVKDLSVFFTSLFNVLPTLVLLLGGSYCAVYRRQ
RELFLMITVYIAYFLLDTQTDFYRDNGRVRADAAVVFHLCCLLLPLLFSIYALWQEKTHL
FRDFVARCAVLLAIGSVALALEQSYPQALLNWLAEIRWPALHGTWMSLIQLSYPMFLVGF
LTLAAQYWYQPRPLHAAQLVGLLGMFWMLPQTFILPFTLNIMCSQVMLMIAAGVAHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMTDVDHFKRFNDTHGHDVGDQVLRLVASKL
SKVNGGGRAYRYGGEEFAVVFAGKTLDECMPHLEEIREIVANYDIKLRNSDRPQDDQQGR
QRRAGSGASSVSVTVSIGVAERQIDQRTAEEVLKSADQALYAAKGAGRNCVVAAGQTRRG
AVRMQSAAG
>H1WD66|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MRRSATLKNGLSGQSKVICLPGGDLDGCGDRIHQINRLKKTRSAQRFGLYTQEAISLNSG
ESKRYCEILIRFIDEPEQVVPASWLVPIITQGYRLAEKIDRWVIETVLDLLSETSPENRE
KYRFAINISSRTLYDYRQWRKLEREILKRDLTPDLFCWEIAESTILANPQKAADAIANLQ
IQGYYVTVDQVGGRYSSLDYLNYVTVDYLKIADDLVKDIAQDLGDRSIVQIIQLVAQSLA
IETIANGVETSPAFETLRDLEIDYAQGYYLTQPHPLAAKFLG
>A0A0G8D778|diguanylate cyclase|EC 2.7.7.65|Bacillus cereus|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCTHQQTIENIHPKCMFIANSFEEGEVLFQR
TKPHIVIMYVTDFSQIKYIKNMYNPQSTFIVIWDQQITSEFAEVLTLGIRNIVIAPVTPQ
MVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFRNDLLFIVEDDEIVDCNTNFLEFFGYEN
LFAYREQHLVFAEHLIRENGYYSTTHDITWLDDTLSYDRRIKMSNYEGEVSTFLLRATPL
PEDLSRFIVKCTEITELDEIYQEQERLAMIDSLTEIYNRLKFQQILEAEWDNAMRNNENI
ALILFDIDNFKAVNDTYGHDFGDLALIELAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFSGISKLTASFGVALYEKGITREELMQRADIALYEAKKNGKN
QVCVYRKEKK
>A0A6B0TD98|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNDENFYKKAVAQSEPPHSPQNDHQRSGLRFARRVRLPRAVGLGWMFLPIAAVLASQPIA
GGWWLFLVGWSFVWPHLAWQLASKAIDPLSREIYNLKADAILAGVWVGVMGVNVLPSTAL
LMMMCMNLMGAGGLRLFIAGMVLMVVSCLVTLQLTGITVAFRSAPLEWWFSLPVIVIYPL
LFAWVSYQTATKLAEHKRRLQVMSMRDGMTGVYNRRHWEILLRNEFDNCRRYHRDATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPADNAI
AAMSRVHERLNALRLPCAPQVILRISVGVAPLTTQIEHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A8E6Y4S4|diguanylate cyclase|EC 2.7.7.65|Salmonella pullorum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPIWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A095EZA3|diguanylate cyclase|EC 2.7.7.65|Burkholderia gladioli|TrEMBL
MSSAPLPADEASRLAKLRSLQLLDTPDEERFDRITRLARRIFDVPIALVSLVDENRQWFK
SCFGLDVRETSRDVSFCAHAILSQQTLVIPDATLDPRFADNPLVTGAPGIRFYAGHPLAL
PDGTNLGTLCLIDTRSREVDPDDLAHLRDLAGLAEREVAAVQMATLDALTSLSNRRGFEV
LARHALNACKRGGRRASLLFFDLNDFKQINDRYGHAEGDRALTLFARSLSTVLREMDVVG
RLGGDEFVALLITSHEVDAPGIVERLRENLDARAEQASLDYAIRFSVGHVDYDPREDPSV
EQLLAESDTRMYADKHRRKSGGSR
>A0A424XKC3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MDERASKPPGLLPLSREDLEKTLRYALEIVSDGIWDWNIATNQVSRSAGWYLMLGYPPNS
LPESVDTWKGIIHPEDYPGVMASFQAYLDGESPEYCEEYRCRTYSGDYLWISDRGRFVEF
DERGEPRRMIGAHHEIHQRKLVELELQQRNEELFDWNLRLEELVAERTEALHRVNQALAL
KMAEAQRLSEIDPLTGLYNRRKFEQCLHQEWMRRQRHGRSTALVMIDIDHFKRINDLFGH
SIGDSVLVDFGHLIAGELREVDVLARWGGEEFILLLPETALEAAAALAERLRQRVRGQPF
EVCGRLTASFGVGVLDDGETLDLLLCRVDDALYRAKQRRDCVTCC
>A0A173SDH7|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKKIALIMDGWKRWFTFAWPAGILQRIRQTGEEVSLYIFNSSGGWSCDEEYNTGEYNIYR
LPDLREFDGIILDLNNIGYPEVWEDVIRRAKESGVPVISIANEIEDFYYVGINNEKAMRM
MIEHLYEKHGCKKYWFVMGPEDNYENVKRIAALRAYMDEKQLTYSESDFYCESFEYQCGV
NGFEKLLETHDKGRLPQAIICGNDNIAVGVCEAATAHGYQVPKDFCVTGFDNFDKAAYYE
PRISTISHIRENVGIACVDLFLHIWKGEKPDRFYYTDTEGIFWDSCGCMPGEVPDQAEYL
KGQVMYGIETARFEDEVFSLEYELLKCNTVREMMYCIPQCIPSLKCDAMYLILDSHMDTY
KEQVKTHRSLSFFEEEDFHVEGYPKCMQVKFAYKNGKMLDTDQMEIEGIFPFFESQKGGT
DFLFLPMHFRNRTVGYFVIENAVYLMEKQYLFQVIKTLTNAMENLHKKEKLEHMNQILSD
LYVRDSVTGLYNRMGYQKLSISYFTIMREKKMPVLVMFIDLDRLKYINDTFGHEYGDFAI
VSIAKAMLKHCDADAIAARTGGDEFIVLEGAKDEESGRVLAQKIRTELSKTQRAMQLPFD
LSASIGAVVAHPGEENVLESYVKRAEMLMYEEKAEKKVSRDS
>A0A069AF64|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNREFMYQHIDDCISKNIHI
GIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKGIVAYLKGEGFLIVLPNVS
NKELNNMGATIIESARELKIRLPNEKEIYSNVTFSIGSTIWNGEPNMNTLMLFNQVYSAL
KKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHVLQTKQIEVFYQPLYNIKNNTIV
GCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDLHLFEENCKNIRRWIDNNDVFVPIC
CNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIEITENILIENTNTIIQQLAELRSYGFS
VSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLSHNLNDFKNTTILYSIINIARALGMLTVC
EGVETEQHVEFIKSINCDIAQGYYYAKPMECKEFEKLLSKENNSEKMFIKYSDIGKSLIE
KIFDGFFIMQDMKKLRANVTEDIQWFDFYNKTEITSFPKVIEHFEKHIKGKKFSILYKSI
TPHNTESDSLLISGEAVLSDEAAEHQKYSNFYFSANCIISENKLLLAKLHLDLIKTAGYI
NEFESYSIPKMTNTHLDESNILSQFYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKE
QFFGEMGGNLRAIVHPDDLDFVYKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLS
AIDGRSIAQGMYVDVNKIKNLTKI
>Q1PZY6|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MANREVLKTVLDSPSLPTLPTVASKLISITSNPETSMAEIAHLISKDIAISAKILKIANS
SFYSFSSKISTVHQAVSNIGKNAIRSLVLSVSFLTIKTNYKNEVFDYEKHWQKSLSAAVA
AKLIMAEIDKTDPEEIFIAALLQDIGGLILARAFPQQYEQTLIALTDDKRDIIEIERRII
GADHALIGYEVTRNWGFPAELLVPIQFHHNPESYKEGNNKLRTATNVVYLSGMITNILFS
NKPQDYHQQFLEKSGKMLGFDNTVINRILRKVHTEIAEVASFFDFQIQNPKPVEEILQEA
NIALSLINLSYEQMNKELIAAKMELQKLANDLEEKNKRLEKLANIDGLTDVYNHRYFQNF
LETEIRRSLRKKTSVSLVLFDVDHFKKFNDSYGHPAGDFILKELCKLVKKNLRDYDLIAR
YGGEEFILVLVETAAEDAAEITEKLREVIASHIFIDDINEYKVTASFGVATMSPAKDEFK
QGDFIDFADKALYESKKKGRNKITAYTHKKRWFGKG
>A0A6X8YJ67|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
NLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMPLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A0D6HL55|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRLVSSNDALTVPQPRVAETDSGNAGDPRDQELARLRQVVAQYEALFHEAPVLINAFDEH
GKCSLWNEACERRFGWTREEINRHAEPLALFYPDPDIRARVLDSVGFAAHRSFREWHPLA
RDGERLSVLWSNVRLPDGSVINIGMDMTESRRNEAALARLAKVDGLTGCWSRAEILQRMK
AMLEAAKRGARHTALMLDLDYFKQVNDRYGHLGGDAALRHFCDQLRACLREGDSVGRLGG
EEFVVLLADADKDVALAVCDRLRLSLRQHPANIDGQALVLSASGGVTGFLETDASMSDVL
RRADLALYQAKRAGRDCAVVLPS
>A0A0F1RVB1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MKAPATPENETDRLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPGSVPRNISFCGHTILTEAPLVVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSVARRRAEPLTLGWLDLDRFKEINDRFGHEEGDKALKAMAQLMRASFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVENYNARKLHPWSLHFSWGLSEFDHNGNDLQ
QWLKDADEKMYAMKQQRQRAR
>A0A5I9C9N4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A174SQG4|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MRLYKRPLFAIGVSLFLVLAVIIITTLIYGNSVHSALKEETDTYMEELTEQSARLIYERV
KSDQTYLEGLAASISELDMPLSSPGTLSILSQWIDITRFKWMAVADADGTLYVPGYPETP
DISREPYFQSGILGESSVMWLPEIDGKSEKLVISVPIHDNGEPEGVLLGRYSMENLAELF
TIGAFDGKGYNYVMKSDGGIIFRALTDSTASEYKTLDEIADNTSNTLTPGDVDAILHNME
TGAGGSITYERDGQERIMKYIPVGINDWNLALVIPSDVIDAKAQAIIKSTSFYSGVMILS
FSFIAILIFYLKHQSHRALQRAYQNIESIYRTVPSSVVQFKNDRDYSILGANNAFYHFLA
YTPQEFDKRIGSFLLPIIHPQDREFLSALPDGLSAHEFRVQDAHGQMKWVYGNFDCSKDS
QTVLCAFFDISEQKKLLMSAEQEALIDPLTGVKNRLAVEKKLPELLCAAEAAGALMIFDL
DKFKQINDTLGHPEGDLVLQKFARCLLEVFGSDNFVARLGGDEFIVYSDDTLTQEAAAQK
ARQLIDKMALQMGMAEKRCGLAVSIGIAFYPSDAGSLPELVKLADRALYRAKHNDGKCYM
FYSEIK
>A0A3T2YJ99|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGGYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379A9G1|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MKAPEIAADEAQRLSQLRALNIMNTPAEERFDRLTRLARRLYDVPIALVSLLEADHQWFK
SAQGYEPAGSPRDISFCGHAILQDEIMIVEDAAEDERFYDNPLVTGEPHIRFYAGCPLRA
PGGAKMGTLCIIGREPRQFNEEDQATMRDLAAMAEAELVAFQTATCDELTQITNRRGFMT
LGQMVLNECRLKNRPACLTFLDLDKFKQINDSLGHREGDRALMDFADAMKVVFKHSDLFA
RLGGDEFVVLFNGLQQQQSEALLLQFDRYLQQQSVSLNRRYRLQFSSGVVEFDAAHPQSL
EQLLHDSDEQMYLSKKQKRVAI
>A0A3Z0Y096|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDSRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSCSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3U8XUL4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYKTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0W2BYG7|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MEKRKKPTLERATWPTRQAMVMHGLAMNLPWLAFVNISFAVMILLRHVLLKASDPLYPHS
PQLTRIVDASMLGIIILSAALILMAWRRIAGISVVLFICSAIWSVSCFWFITQLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPIASWIRNDGLNLHFVVIWSVFTLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKPFSL
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPEDVVSRYGGEEFLVILFNCPEN
IAEKVALRIQDGLRAEAIPHGASTVSDHVTVSMGIAGMAGGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A078BJW5|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. CB2|TrEMBL
MHLITPLLIDLGIVALAMAGVLMLAWKLLQQLWGTGTSSAYQPAALLFSAGVATAVRNRF
PWMRAAYRQRPDRKLMLTAAVILLLASSLTALFTALVMADHERNRLTLSMENDRDALSRG
LLMAMEVRGKELERFSHNPLLLRTLRTLQTGKEGSPAHPSAELQSQLADLRTMMALLAPH
EYSITNLWGETVLSSAASTAHHPGLPSLAPAMPPASQFMLQRDPVTLNFFLHAQLPIRKG
EQTIGHFSASLPLPASSRIAHELTRRAKHTVIKICSLSNDLWTCLPSQAGESEQTTRLTS
KRLPAEVRWAQGKAATTIQEIDGQRWLISSTPLGTTGLALAVEVPTAELYAPVVDTLETG
LLFVPGLVLLGLLVLGWQLRPLTQRLHQANARVQNAFDYSGIGILMVNGQGEILDFNPAF
SEMLGYTPAELRQPHVVDDFLHPDDRGAVAAQLGGMADTEVGAYCAHRRYRHKNGRYRML
QWHVSPVKNEDGAVTSIVCYALDVTDELARRDAAIRQTAFLNAVLDNMRDVVYACDENGL
LSYVNAAAIRAGLPTKMGVSLRELELVTPVHTTDHKPVPLEQLPLESALRGEPKEAENFL
IESLEGQWRHYEITARRLLDSTGTPLGAAAVAHDVTEIRAVDRRLKWLIDHDELTELPNQ
TLVIESLERLLEAETSRDESRQLAVYLLDIDRFRQINDSFGHALGDDLLIETAARLKVAL
APDDFLARWGGNAFAVLHPCTADQQALLDHAEQLLNSLTEPFVLDGQTIFITASLGIARA
PRDGRSATQLFSRADVAMYRCKANTPGRALLYTADMSQRGRELIEMETDLRHALAMEQFF
VLYQPKVCLQTRQVIGAEALLRWQHPQHGLVSPATFIPLLEETGLIVPVGQWVLNAVCKQ
LQEWEQQGKTPLPIAVNCSMRQLQGDLILRQVSSALEHSGIAPGLLELEITESMMLRDPE
HVSGLIVQLRELGVNTSIDDFGTGYSSLASLKRLPVTTIKLDRAFVKDLPNDADDAAITR
AVISMAKALHLIVIAEGVETQEQADFLQQLGCEAYQGWLFSQAVAPKRFAQYLADAKTHT
PG
>A0A379W8V1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A5W2RKN3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3S0IF84|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MKAPLIPVNETERMNALRESGLLEIDNYPAFDRLTRLATRFFRVPLAMITLVDDHAAIVK
SADGRALASQPRDLSFCGHTILGDAPLVVADTLLDERFADNPQVAGDPGVRFYAGFPLRL
RDGACVGSLCLIDYAPREFTAADSAVLADLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
FAQFALSVSQRRAEPLTLGWLDLDHFKTINDRFGHQEGDKALKAMAALMRSSFREADMLV
RFGGDEFAVLFADTDEPGAWIAMQYLVEQTEKYNARQLHPWSLQFSWGLSEFDHHRNDMQ
AWLKHADAQMYAMKRQHHGEK
>A0A132HPY0|diguanylate cyclase|EC 2.7.7.65|Cupriavidus metallidurans|TrEMBL
MHSASDTGQLVPSDRFLSRLWLALIRRPRRFILIAFSAAILLILLLIFRGMMLSRDAEIE
SVRQMQAVRAVSINALLQLEAERLTNIRNYAEHLMQIQDELPALFAHDIQTAFEHRNDDV
WALRTRDAAPVFGVSAAQLTGLDGFLRDDAKLIPSMAVAIALSHMFSAGHNEPGLRERIA
YVSGNGIIVAYPAISEQDVNPTLRSLASAAYFRNNLPLANPTRKQQWSIARSMDDIGESS
LFLSAPVYAGNAFKAVLILEIPRHSLDESLNVAPHHDVNNYLVDHNGALMGASMRNVHRG
ETLASVLINKWPADKLAVAFRSDAGILSNEHGSRLIYRKLGNSGLIMVDEVSTRELLQAS
VARLSGAIGAGAVALGLLLCFTLAIVHTLFGHYIARGEALRTLAETDALTGLANRRVFAS
RFADAYAWCKRDAVPVSLIMLDIDRFKKINDRWGHASGDVVLRTLADALRANVRNVDLPA
RLGGEEFAVLLPRTGIADAANLAEKLRLALQALVCEPVDSDDTASIRFTASFGVAQIAPD
EPGNLDSLLMVADQRLYAAKAGGRNKVVWDEPQPEEMANEKPVKGT
>A0A081M5W8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRTADEAMYQDKKSRRQENFIHID
>A0A483ZPV7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLNQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A3T3ZGW8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYELCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3L5JY09|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNHPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8G9AZH3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKMLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRRTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRELNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGQGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLPGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A232Q3V4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A099B1H0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H1PLZ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKTVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A1Q6BFS0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTIRNTKNLSNKTLRVRFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A827XBA7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A0K5J522|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A1Q6B8I5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAITQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVT
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A090H0F3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3K3UN80|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A085NXD5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A143DVE8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSILQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A246NT06|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVALLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A853SU81|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MGDQQKRLQMALEAAHMAIWDSRIVDGQVIDGTVSWSAKGAALLGLEERALTQPFRAFLD
CVHASDRDKVMTVLQDGVRRREGYALQYRVVWPDGSEHWLAAKAQIFMDADGHPERTLGI
IWDITEHMERELLIAESKELAEVTLSSIGDGVITTDPQGKTRYLNRVAEQLTGWSNELAQ
GLDIWETLKLVDEHTGAPLEHVAIKCLRQRQAIGISTHAQLVTREGRHIAVEDSAAPIWS
RDGEILGAVVVFRDVSHERKLSQQLSWQATHDALTGLINRREFEHLVAGALHTAKQDGHT
HALLYLDLDQFKVINDTCGHGAGDVLLQLLAKMLQGRMRDSDILARLGGDELGVLLPHCP
LDHARQIGEQLRQSIRDFRFAWDNRSFELGVSIGIVEINQDSKSMSELLSAADQACYLAK
EQGRNRIHVYQESDVMLAQRHGEMLWISRLNEAFAHDYFRLYAMPIVHLHDREEHHDEVL
IRIRNSKGDLILPGAFIPAAERYDMMLPIDRWVIRAVCAHIESVRDSLPPLEALAESRRR
APALYSVNLSGMSLADTGLHDYITEQFVQFAIAPEQICFEITETAVIANLPKAQVFMRQL
KAMGCRFSLDDFGSGFSSFGYLKALPVDYLKIDGVFVRDIATNAINRAMVKAINEVGHVM
GLQTVAEYVEDEATLAVIRELGIDYAQGYAVGGLRPLTAGVD
>A0A0K5SYP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEVVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A7H9QQK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAARGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFFPIASTL
VSHPPSGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTALLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A7H9QVT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQNMHNCGRELMLAIVENRWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLANWTRDYEAVYRYGGEEFIIIIKAANDEEACRAGVRICQLVDNHAIAH
PGGHIQITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDQQSVINRVLAPF
NIH
>A0A3J6S8T9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A3Y8YXN3|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3L2NI33|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHRLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVT
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2S5ZH16|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3V4SRX1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Altona|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0C2E924|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A6P1K5N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEQDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A181W1F1|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVTPLFTVVRFTLPCALIVACSGLLLLW
HWKWPQSKINISAISLLFGMLWAWHVVTKAMLLTPPHFNYLVIALLSILFIGTIAFSNNI
TAFTLHSLPTFLACLIMAEGEQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMQ
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHFVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSEETAWQAAERIRQRVYDLKIPHM
FNESVATNVTISIGLTPLIDDNIEQALARADGALYEAKNKGRNIILAS
>A0A5J2UTR1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mikawasima|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFAQRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A177Z7N3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MLAARFHVETRYVHMAKNIPMTSPGPVPPGAARTLLALLHAQGEVARLSEREQLFSSLLE
SVNAVLWAFDWETREVLYVSPAYERIFGRPASLVLADFNEWRDSIYPDDLEYAERSLAQV
LLKGAVEDREYRIINADGQVRWLSDKCYINQQHDGDRVIIVGIAEDITEKKQLEGELQRL
ATIDVLTQSSNRRHFFECAQAAFDSARENGTPLAFLLLDIDDFKQINDSYGHQEGDQVLQ
HIADSGKAVLRRGDLFGRIGGEEFAAVFPGCSAELAGQIAERLQRQIQRLSFSHGAHTYG
VTVSQGLTGLTAEDVALDSLYARADAAMYQAKRQGKNQIVRG
>A0A3U3R720|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A729FQJ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4Y6N3T3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Indiana|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V4W199|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALTQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2X2IEU4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAQNAQL
LRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFIDGDNFKYINDTWGHATGDRV
LIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8E7N6C2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
TLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y3XWQ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHCRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A701T1Q2|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A747C1P2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQVGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A764QRN5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A485BLH0|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFFGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALSLFCYCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALGAFRFRQLLPVIALVLSIILGVSVGGAGSITFPLPALIWCAIRYPLPLTCLL
TFITGISEILLVANSLIHLSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINNLVKQ
LALRADFDFQTRVYSRSGLGEALKRQPLAEGQLLTVMVLDIDGFKRVNDSWGHECGDCVL
AQFAQQVRQLAGEQGMVARIGGEEFAVATLTSSMQESQALAEKIRQGVEAQTFVWGQNQI
RLTVSMGLESRPVGNERITELFNQLLMAADDYLVSAKKAGRNRVCTPGLA
>A0A627ESA2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
AGSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A754LZ06|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
AILLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3T3IEY4|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDSRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSCSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5T5I9R4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6Y0YW41|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A378GLV1|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MSDIILARVSQTLATEQSLESLVRQLLEMLELVTNMESTYLTKIDTQADLQHIVYSRNSG
EMNIPENFSVPWGDTLCKRAMDDGCFYSDHVPEQWADCDAAKALGITTFLSTPIHLTDGS
LFGTLCATSTEQKPLSFNSEHVLQLFASIIARYIEKESLVAQLQEANAALIYHSYTDALT
GLPNRRAVFENLETLFSLARHLNHSVMLAFIDLDKFKMINDCYGHQAGDAFLQQVGQRLK
LGISPDDQLGRLGGDEFMVATLARTAVQLEHFAETLRQLLIGDYLLGDTLIHYPGASIGA
IVVDPNVMDPDGALRAADSEMYQDKKFRHRPEITAQRVE
>A0A3T3IMT0|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>G4SY12|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MDRTEQPLSKPALSLNNVSILCVEDEHEPRKVLANYLRRRGATVFEAENGQEGLRLFESH
RPDIVVSDIRMPVMDGIAMCQTIRKLDADAAMLFLTAHSDTGLLQKAIDLETIQYIIKPV
NADSLNSAFRTALDKLHKKHSLNETLNQLHTTIELQQEETERLQGYVSQMIGNDRNIAVH
AITRPRDKISGDFYTIEHTETELYVLLADGMGHGLSAILPALNIPKKFRELAGRGFSLSR
IADELNQALYDQHLSGHFLVATLIKLDPRQCLIEVVNCGNPPVLLTDSNGRIVHTFPSNH
LAWGIVGGDDFLPEVQGFHCDTTAKLYIFSDGLTELLEHQTQKQGLETLIEQIAETGHNS
YLNRIDGYLKSIPKTLYHDDITLLEIAYGPELLDQQDNRVNDSVLHLPRQKNDTTDDLSP
LKWISVLYVEDDPDSLACLSKFLQRRVGVLYTAENAETGLRLYKKYRPNLVICDIVLPEM
NGLQLVEHIRVCDPNVPIILISGIEPGPGRVAQVEAMLDLEINKFLAKPLTEDKLVSTIL
QCIKHLKYINSLKLSASVFMASPLAISITDHNRNIIAINPAFTAITGYTFAEVEGCNPRI
LSSGKHDSEFYRQMWKSLNTTDRWSGEIWNRRKNGELFLEWITVNAIRDEEGTLTHYASV
FSDITQRAVAEDKIRYLAHHDPLTGLPNRVLMLDRLNTAILQAQRDRSQLAVICLDIDNF
KTVNDTLGHGFGDELVKDFAQSVLSSIRESDTLSRLGGDEFAILLPRISSREAAARLADK
IFHAVKKTYRLAERELHISFSMGISLFPDDGDNTEALLKHADSAMYLAKNKGRNNYQFFN
QKLESQAERYMLIQHGLHRALKLKEFYIHYQPKFALDSSLIVGAEALLRWRSPTLEDITP
AEFIPIAEETGYIVDIGCWVIEQVCQTLAAWKATGINLVPIAVNISPIQFHRGNIKKALL
KSTINHRLDPSLLQIELTEGVVMSGQQKTVQQLQELKDLRFSISIDDFGTGYSSLSYLRE
LPIDELKIDRSFIMEISDESSFNNPHLTAIPCAVIDLAKNLGLNLVAEGVETEIQSRFLM
QKGCNVIQGYLFSAPVDKDRMWELLKEYS
>A0A518H1Z4|diguanylate cyclase|EC 2.7.7.65|Tautonia plasticadhaerens|TrEMBL
MLTSTLLPAPGPPEGPGFDPLADPARLSALSRTGLMDSPPEGAFDRLTRLAGRVLRAPVA
LVSLVDDRRQFFKSALGLPEPWASRRQTPLTHSFCRHVVRSNGPLVVPDARLDPLVRENL
AIRDLGVIAYLGAPLTTSEGFTLGAFCAIDGRPRAWDDLDLEVVTEMAASTMAEVELRME
VSQRREAESRLADSLRRAEALNLALRARTSELADCNARLELLARSDGLTGLLNIRAMRQE
LEDRAAFCLSAGLPMSVLMIDVDHFKAFNDAFGHPLGDDVLTTVAGLIRQGIRQEDLAGR
YGGEEFIVGLPGCSSTRAEALAERLRASIASHPWPLCPVSASVGVSSASRPSDLPALIRA
ADEALYRAKRDGRNRVCVAEPLP
>A0A5C5D524|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. B2|TrEMBL
MIKQSAKELIALPPFVLPVGLGFLSFIFTYYSLELSLVGTVLAPLWFPTSVIMVALFRNP
LRQWPMVIVVCALGSLSASMILQPLNDINLGYTAINIIEALVGASLMRRMLPQHNPLQNL
NNWVQLVICSAIIPPVIGGVLAVWLDDSGIGSFVKTFFVWILSETIAALAFVPTALLFKP
NYLLRHKNPKLLIETIFTFVITLSLSYLALRYMPWPFTFIIVFLMWSAIRLPRLEAFIVF
LGTLMIVSLMMATHATTIQQPHTTIMENAPWLPFLMILLPANVMTMVMYSFREERKHITE
SEARFRNAMEYSAIGMALVSTDGQWLQVNKSLSKFLGYTAEQLRSLTFQQITHPEDLHAD
LQQLNMLVSGSINSYSMEKRYYTSKGDVVWALLAVSIVRDIDGSPLYLIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLGTDVISWDKRMFDLYEVPAHVKPTYSLWLECI
VPEDAPSAEKTVHEALKARVPFKMEYRIHVKDGVRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNITFMNPIAEKLSGWPQQQAIGQH
ILTILHITFGDNGPVMENIHSGDYSRTTIEHDVVLHCRNGGSYDIHYSITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRASFESHLKRLLQSAGENRQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELSSLMLSMLRTGDFLARLGGDEFGLLLPDCSADNARH
ISERIIQSINDYHFTWNGRLHRIGASAGITQIDADNRLASEVLSQADIACYASKNSGRGR
VSVFESSQHDIRKDSQEMSLEEQKRIINENPILMVARGVAPPRVPESTSFYLVSLRFWGS
DDVVIDESKFRAAVTDKELQCALDLRIFNEFFSKFSQQVANKGFGIALALSTHSLATDRV
IDELLERLSRSALPERLLHLMVHCEALQSEDEKIGRNLQRLHDSGCQLILSNVSRDLDIF
KRVSRQCFSYIIVDEELIQNVHCNLMDEMMVTIIHGHAQRQSLQTIAGPADLPMVMDTLS
GLGIDLIFGEAVTQPAPLEMLLNTSYFAIN
>A0A377RQ21|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MSSKLPSPPASAPAGATNTAAAMNPADIAREAFRRLATRRIAPTPSAYRDIYNEIAGISE
PADSAVAPGAVLAASAPTESGAENVLTQFAAKMSESAGELGDFGKRFQRALKARDWDSYA
RTLAQLAEKQVKKGGGIELPPLPDGEQTRTLRELLSRTLGFAVATLLTGTPALVEEAESL
GAAIKQAHTEEALNEAALRLKQLCYQIELKSGDTAEQQELLLRLFKLLLDNVSQLLDDDS
WLRGQVDAVQNLIAGPLDQRALEDATRSLKEVIYKQSQLKHSLSDVKLTVKNMMMTFIDR
LGQVAASTGDFHEKIGGYSEKISQAENISELNSVLDEVLRETRMVQNEALRARDKMVLAR
QEVQDAEQRIHTLEAKLQHMSELVREDQLTGSLNRRGLDDVFERETARSDRRGTPLCIAM
LDLDDFKRLNDTYGHLAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILLPETTVEAAS
STMTRLQRELTRHFFLHDNEKVLITFSAGVALRLPNEDQAELVKRADRAMYQAKQTGKNR
VVVAE
>A0A1Y5SML8|diguanylate cyclase|EC 2.7.7.65|Oceanibacterium hippocampi|TrEMBL
MSHVAIAENFGSTVFPVFDGQLGPDAERLNALLKRTKLGNAADRRLIEEVLAFAATAEQR
LIQQESRIAELKSISMSDELTGLLNRRGLMDNLNRTIAAARRHGEGGVVVFLDVDNLKTI
NDECGHDIGDAAIRHVARVLAENVRASDFVARVGGDEFVVVLVRADRKQGLVKAARLQEA
LASSPLHIGKKELPLGASVGASAFDGSAEAEDVLRSADLAMYRDKRNRRRCRTN
>A0A381H6P6|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNDENFYKKAVAQSEPPHSPQNDHQRSGLRFARRVRLPRAVGLGWMFLPIAAVLASQPIA
GGWWLFLVGWSFVWPHLALQLASKAIDPLSREIYNLKADAILAGVWVGVMGVNVLPSTAL
LMMMCMNLMAREDCGSLSPVWC
>A0A4R0XVP6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4862|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLNTLNAWLLESFSVGINKRYSEAVQKQHKVGHVHARVGIPSWLIMRGICEIERK
VFELVAQNPQQDMFTVCSYIVQIMGFSTEIMCRSYEFNLEKNNDIKHTYRLFSAMQDVAS
QKDKQRSSLLNWENELMFKVFSDELKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVSVIID
RIYQIDLLSQQVLNAIEKDKAIQLIQDIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNTPLSLLAIDADFFKRINDKFGHAAGDLALQFIGEVLLESV
QGSDYAFRVGGEEFLLLLVDSDLGRAQEIAENIRRCIQETTIRTTMGSSFNFTVSIGCAL
YDGHPDYQKFLDTADTALYAAKNSGRNRVYLAQNELQVAVANTPESVQL
>A0A6L3PIG7|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MDLQQIDLSLKELNHAVKLHYEWSGKFLELVLLGSEPDNTFIHPQSHLYCRFHHWVVSCD
NIPSRYARFIGNISETHKTMHDYARTLIQSIASKRVDSDELYAYHDAQQQFVASVDDYRQ
QLISLRNRHDTLTGLPLRQLMYEDFAFLHAHAREQTLWLLIIDIDRFKKVNDTYGHNAGD
DVLREVAQRLKTEARGGERVYRFGGEEFIVLLDAHTSQAAREAGLRFCGSPGRRPLRLNG
ETLTVTVTGGLTCVRPDETLHEAIGRADDAMYFGKNNGRNRCILTLDGLMRETLK
>A0A3S4J6L7|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNDENFYKKAVAQSKPPHSPQNDHQRSGLRFARRVRLPRAVGLGWMFLPIAAVLASQPIA
GGWWLFLVGWSFVWPHLAWQLASKAIDPLSREIYNLKADAILAGVWVGVMGVNVLPSTAL
LMMMCMNLMGAGGLRLFIAGMVLMVVSCLVTLQLTGITVAFRSAPLEWWFSLPVIVIYPL
LFAWVSYQTATKLAEHKRRLQVMSMRDGMTGVYNRRHWEILLRNEFDNCRRYHRDATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPADNAI
AAMSRVHERLNALRLPCAPQVILRISVGVAPLTTQIGHYREMAEIGGYGAL
>A0A8F9IXB8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLKREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>A0A2D1QI23|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MRVERQCLIRSLFDEYIEMYSARDVRLVTRFSDNFSGYAGSSDQLVTDREEWIRITRKDF
AQIPERIHIEMLDLSLQDLAEDVVVATGFFHIHLPIPDHILSRETARLVLIFRHEEGEWK
IAHSGISLPYGLAQDTEVYPVARLCERNLELERIIEIRTHELAEANRQLEILSNTDALTN
IGNRRLFDHILQQEWNRGLRSGIPLALIMLDIDHFKQFNDHYGHLAGDSCLRALAQALSQ
SGRRAGELVARYGGEEFVILLPNMNMQAAFDTAQHLHRLILTLALPRTDSPLGIVTVSFG
VASLQPSTTQSAIELVQQADAALYHAKLAGRNCIALSE
>A0A643EF99|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATVAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGSALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G6V3P7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVAVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLPDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G1NKZ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPKEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPMRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>T0P9A6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MDMLKAPLREVVTRFDPTLMADAMALLEAGLWSWSPQQGVQRDLSCLRLLGLSETGLDDL
GWLERVHPDDVAVLQEALAACQSGRVPQIRLEYRILHHDGHYVRLEERARRDVHGQVLGV
VRLLESQAVAEERHGTDPLTGLESRSHFEQLLDERLATESGSFSLLQFTVDHSAKIQQLF
GEAACDAMLAKLARMVRHELRREDPFARWDQDGFILMLSQTDRLSGLEIAERLRLEIADA
SLLPQRPVTVSVGLVQSQAGEHIDHLLARLATCHGQARREHNAVVG
>T0QVY6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MQLTQSVTRQVKQAIMAQLYTHSSFSLPCLGLLALGWSLLFHDYLPAGEALGWLALVCLL
LLCRGWHLRWRQSSLTQTPLPVLERELFIGVTITSIIWALGVLLYMDKLPDTYRAAMMML
SSLILTGSAIMLFGSRRSLYGAVLPLGLAMLFELGAGNEQERIVSCMLAGYLFVFLPTLL
RRLRRDQVASLYHRFSNADLVAELKAVSEHLRLTSRLDGLTGIANRAHLDDSLERAWRRC
HRARVPLSLVLVDVDYFKQFNDLYGHQQGDECLQRVAALLAEVQRREDDLAARYGGEEFA
LLLPCTSMQGALQIAENVRMALKDLGIPHQKSLVSGRVSCSFGVATLVPDQSGSIAELIQ
KADAALYQAKHNGRDRIEVALMGKVA
>T0QRV9|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MDASILLKLDVFTLMVMALGGYSLGFITLSIIWLTHREIPGLGFWWWSSLCALAAQSLFS
LQAFMPNLAGIWLANLLITVCIALMPLALQRFFGKPLSWGASALFMLVYVLILSWSILFN
DHMAPRVLLACLSYMVLGAVIVFLIWRHGYPAYLPAVLVFTVVNILLYGFNLMRMGFLLE
GDARGLMDQSGVNVLPFLSMLMGSYLSTFGVLLLCTQYRALALRQQASHDSLTGLLNRRG
FMEQMGARRIGEFGALAVLDLDDFKQVNDRHGHEIGDRVLEAVGAYLGAQPELVASRFGG
EEFVLLLPREDEQAQQARCERILQDLAALDLSGIRITVSMGLARCQHDWHFDTLFSQADG
ALYQAKREGKNRICRLA
>A0A1V6GRA0|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MSDSRERIDHLTAELDRARGRIAELESEAASLRRCEDDLRESVEKYSLYFSIVNDVIYSY
DPDFTLLSVSPNVERLLGYSAEELVGKPFHELGVLDEGDLDRALKDALHVLNGGTIHATV
YRFVTRDGRMVFGEVSGTPLLRKGKIEGVISVARDITRRIDLEKSFREEAEKYLAHFPLT
SDVLYAVDAQLVLKTVSPSVKHVLNYSPEELIGRSLRDLDMIHPEDVDRAASDTLRMLSG
DKMEPSVYRFITSAGEVRYGEVKGIPLMENGSVAGVVAVARDVTGRVMAQEKIRTYQDRL
EELVRERTAELIRANESLEKEIGERARTEDALRVSEARYRLLYEGMEDAFVQVGMDGSIQ
EFNPAYPRMLGYDPEDLHTLTYLDITPSRWHAYEADILRSQTMVRGYSELYEKEYARKDG
TIVPIELRTYLVRDAQGQPSAMWAIVRDITGRKKVEMALRESERRFRDLAENTSDLIWET
DEQLRFTYMSQKIVDHLGYGPEDRVGRTLLDVIPREDSLRLGPFILSLMEQPRPFQNLEY
TALHQDGSVRIREASGVPIYDSEGRHVGYRGVTRDITERRKAEDRLRDSEAKYRFVAEKM
SDIVWTMDLNLRTTYVSPSVTTVLGYTPEERMQQEPRDQLTEASYEHATGLLAGEMEREG
QEGVDPERMISMEVEYIHKDGSTVWMENVISGIRDEHGTLIGLHGVSRDITDRKRAEEQL
LASEKKFAAAFHSSPAPMVITSPEDGTIIDANQACQEWSGYTLAEAAGRTTTEMGFWQGP
GKRTAFIHEMMGKGAVDGLEMEYTNRGGEARDVLHSARLIEINGRQCLLSHIQDITEKNR
AEKALRQSEERLRGMANNFPGVVFQFYARDNKEMGFYYLSERTINVMGLENDTGDFLDRS
LACISPEDLERFRAAVRESIRAESAWDFACRFTKPGGKEVFLRGISQPVRHAHELVFSGV
LFDVTQQKLLDEELRRHKDQLEEMVLSRTSELIRTLQMLTDEIEIRKKTEKTLRYREMEL
KNRSIELEEMNAALKVLLKQRDEDRSTMEMNVLTNMKTFILPHIERLEKAGLEEGQIKSL
WMLRGHLEEITSPFTRRISSEFLGLTPAEIQVASLIRDGKSSKEIARILNISINTVHTYR
FNIRKKTGVKNNKVNLRSFLKTLE
>A0A498QUN2|diguanylate cyclase|EC 2.7.7.65|Mycobacterium pseudokansasii|TrEMBL
MNALHLSVPAASSSPLRFALFDYVSGMERLVQAVQELSLARSLPDIQRIVRSSARELLGC
DGATFVLREHDMCYYADEDAIGPLWKGSRFPVEACISGWAMLNRDAAVVPDIYRDPRIPH
TIYRPTFIKSLVMVPIRKLDPIGAIGNYWAQQHRPTEQEVCLLQALADSTSIAMENVQVY
VEMERRVRDRTAALEKGHEEIRRLSVTDELTGLNNRRGFYLLADAALGAARRQGRDCMLA
FLDVDGLKRVNDQLGHDVGDTLIADVARVLRTALPESAILARMGGDEFCALVTDVDCDSA
TLKARLVAGFRHFNETSHRSYRVSASIGVVRARAADVNAIDELLAQADELMYAEKKASPS
SRLAD
>A0A5P9F2X8|diguanylate cyclase|EC 2.7.7.65|Sulfitobacter sp. THAF37|TrEMBL
MQRVRWILVAFAFLAGTIASELFSDAIAKSTQIRFLSDALRHEVPVNLITLAIFLAGVLA
ASISYFSDRLRRSEAEILRLSSEVDIASSKLHDLNLVKYIDRTTRIPNETKFEEELADVG
KAASSGQPFQLAMIDLQNFGTLNDTIGYSAADEIIRAIAQDMFKTMRRNEGMFKTTPNEA
SDKYFTERLYRKHSGGDEFLIIVEGPEFEALGLLNRFAGNAERYSEIARTHGSDWRFGFH
AGICPIERNDTAALARKRVEDCLLVAKRSDHGRSMYWYSELKADDTEDDRWQRLPPFAQN
IYRKATSLTFDDAN
>A0A157MTH3|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MYESAPAQAQVPATPSARLAQAVCCALLAATILFLCCLVGIWSRPPGLLAALWPANAVML
GMMIRWPRMAGPAGWLGAAAGYILADLATGGALSMTLWLTLANIAGVFTGWTLFSRLEPD
EQRLQRPSSVMHLFGICAAAAAAASLTGAGITTAVYAQDTLTGLTYWFIGELANYIIMLP
VLLTWPGLRRVALLRRSADVSALLGRGLPALALAASLMAAMAIGGPGAIFFPIPALLWCA
LTYKMFAVSLLTMGSVIWAQLYSSRDMTGEVMASFIHATTSIRLGITLLALAPLTVASIN
AARNRLLAELEYAAHHDSLSGALTRAAFIKRGTQIWQGRAPSRCSAAALMLCVDGFRQVD
DQYGYWAGDRILQAFARQVRAVVREEDTFGRLGDEEFGLLLFGISRQECLGVGERLRAAV
ESMEIVLDDGSRLSATITVGITWIPDLNDTALGRLLVRADAALHRAKKAGRNRVVDDEDL
SLLRV
>A0A8E1V6B4|diguanylate cyclase|EC 2.7.7.65|Pantoea dispersa|TrEMBL
MPISPLSSRRMTPALRVHLCFLAVFLFSLFLTVHEALELKNNYQQRQRAQLSEIQRSLDS
RFQESLDELNYYQRMLSYALTHPLDADYGQHALQRFQQLRHQPMWQLQIANLRSMPINGV
SDEWLQRDALLQRDDTYLLPELRAALEFSFIMQFSDEAQDFHSRFWYTSRAGYYISSRPP
RDAQELAQSYATMTQRPYFRDQQPGRAPQMRWHWTEAYQGEFNEGLMLTVSAPVIAHQHW
YGVLSMDFTQQRINALLQQSRHSVLQGKLVLEDRALNEITRLPAPHDVALTPAQRGQLMQ
AMHQQPAGTLWLDSQLASWVKLKNVDAWLINVQSLRQGLAQALGRVALFLLGMWLLFVLL
LALAHQVIFRLVRRLEDLSARLAWRANYDGLTRLLNRSAFFDQFIALARRCEQQQQPLGV
IQLDIDHFKKVNDSWGHHAGDQALMRVAGVIKHTLRPYDVAGRIGGEEFCIVLPHTTLAE
AQGVAERIRSRLAAKTILVNASTTFSVTLSAGVSCSTEQGSYHAESLQAVADRRLYLAKS
GGRNRVCAAG
>A0A518XDR5|diguanylate cyclase|EC 2.7.7.65|Pantoea dispersa|TrEMBL
MPIPHRRINPYLRVHLCFLAVFLFSAFLTAHEALELKNSYATRQQAQLAAVQQTLDSQFQ
ESMDELNYYQKMLSYALTHPLDADYGRAALQRMQQLRQQPVWQLQLPNARSMPVNGVGDS
WLARDPLLARDDARLEQELRAALEFSFIMQFGDETQDFHSRFWYLSRAGFFISSRPPQSA
QALEQSYATMIRRPYFRDQNPANPQHARQRWTQAYQGGFGEGLMLTVSSPVISEGYWYGV
LAMDFTQARIRALLMHARQNLPQGSLLLLDRRQQPVTGLTAPDDPVLTPAQQAQLAQQIR
QQPAGVLRLGTRFASWSKLKNVDACLVNIQSLPQGLSQELGRVALFVLGSWGLFILLLVV
AHQVMFRLVRRMDDLSARLAWRANYDGLTRLLNRSAFFEQFVALAARCQQQQQPIAVIQL
DVDHFKKVNDTWGHHAGDQALMRVAAVIGHTLRRYDVAGRIGGEEFCIVLPETTLAEAVQ
VAERIRARLAAKTILVNASTTFSVTLSAGVSSSEEQGDYHAESLQAVADRRLYQAKSGGR
NQVCAAD
>A0A533QI38|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MANPSNPSEIAREALRLLAVRRLQPSPDNYRALYHEIAGSQPAEALPQREFKALLASLPQ
ETLAQQRLARRLEQAFAASNWQQLGVGLSDLVRQLGKEQELPWNELFGDFLREWENKQAG
LTVARKREALERVLAGGSSGGEVLFGRLQGLVKSWSAAGPAGGDIPLLASEAVEAGSIGL
QAAGDGAATARDDGSDASAQLRDLFAHLLEALIGSQLASEPDLAADARALVHKVRTATSR
SALDDLLAGIKRFAFRLELLAEDRAELRAGLLKLLQLLIENVGELVVEDHWLRGQIDIVR
DIVAGPLNVRSIEDAESRLKEVIFKQSQLKHSLTEARENLKQMLAGFVDHLAEFADSTSD
YHDKIEACAAKINQAEDITQLEEVLAEVIRETRIIQLNAQRSRDDLRAARERVGETERRI
AELQQELERASTLVRHDQLTGALNRRGLEEAFEKEVGRARRRQSTLCVALLDIDNFKRLN
DSLGHDAGDAALIHLATVIRETMRPQDTVARFGGEEFIIVLPETPVEDAQTAIVRLQREL
TRRIFLHNNNRQLITFSAGVTEVRPGDTQASATKRADEAMYAAKQAGKNRVLVG
>A0A8B2S940|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. GER_MD16_1505_Eko_090|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>A0A0M7BWZ1|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MPAAILMCAAGLCAARFIGFNTLRWGGALACLGAGYAVMLVQAAELAPYKQVVEDAFILG
GVILACRALQGRRGRQAPPCFDVAILLASTAMVVVSVVLFASAKLETFFVQACCALVTWR
AALSFARHAATTSDRVLTAAFLFIALVLTGQCILYLAAPTPALAAGEWRTSVWGILIQYT
GLLGSIVLTFAVFIATSYDAIEKYRRHAHTDALTGLLNRQGLDNLLASSSTRPLSDGPTP
TALIMADIDNFKRINDRFGHPFGDMVLARFGALLRPRTHAQAHAARLGGEEFLLLLPVAD
LASAAAIAEEIREDFVAQRWAPQAPDSRFTASMGVTLAQAGESFTSALQRADDLLYAAKR
RGRNCTVAGHAQADAGPGLAAFRDAASGESSTHDFEARAAVQRG
>A0A174H1V8|diguanylate cyclase|EC 2.7.7.65|Fusicatenibacter saccharivorans|TrEMBL
MKTIMKYELVINEALRSALNYHTPDEQINEFIRFFGRHISSDRIYIFEDCKERHVTNNTY
EWCAQGVVPEIDRLQNVDMDIIKWWYDTFSKGESIIIADIEDIKEEHRMSYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKGDYRGLTIFLDMIGTLLISLVKLRNSFIKSNKEARL
SSYTSLSKIYTSMHLVDVQTKKYHIVKMTDQIVEGLGKDFKKMGEYEIRDDFCGHINDMV
EKMCIESQRQESLEFVDISTLEKRLLGKNNISHEFIDKKSGWCRSRFIPVDYDENGRLLH
VLFCIECIEEEKKRENWLIYLAKTDLMTGLCNRGSGEKRITELLKEKTKGLLCLIDCDKF
KSINDTYGHSVGDKAIIAVAKTLQKTCRDSDVVMRLGGDEFAIFMPKMLEQTVAEKFFER
LFENIRQIDIIEMRGKSIEISLGACFYDGYEDVSFDQLYRKADRAMYQSKKQKGCSAVIY
GEGM
>A0A174E4N2|diguanylate cyclase|EC 2.7.7.65|Fusicatenibacter saccharivorans|TrEMBL
MKTIMKYELVINEALRSALNYHTPDEQINEFIRFFGRHISSDRIYIFEDCKERHVTNNTY
EWCAQGVVPERDRLQNVDMDIIKWWYDTFSKGESIIIADIEDIKEEHRMPYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKGDYRGLTIFLDMIGTLLISLLKLRNSFIKSNKEARL
SSYTSLSKIYTSMHLVDVQTKKYHIVKMTDQIMECLGKDFKKMGEYEIRDDFCGHVRDIV
EKMCIESQLQESLEFVDINTLEERLLGEKSITHEFIDKKSGWCRSRFIPVDYDENGRLLH
VLFCTECIEEEKKRENWLIYLAKTDLMTGLCNRGSGEKRITELLKEKTKGLLCLIDCDKF
KSINDTYGHSVGDKVIIAVAKTLQKTCRDSDVVMRLGGDEFAIFMPKMLEQTVAEKFFER
LFENIRQIDIIEMRGKSIEISLGACFYDGYEDISFDQLYRKADRAMYQSKKQKGCSAVIY
GEGM
>A0A1E3GW74|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MMTGSKPELPLRRYVDMHIIKSMLLVGIAYYVAALIAIHQTITPEGIAILWPPNAIVLAA
FLIYPFRYLPFIAAAGITAELVASAPFFPLWSAICFALINLSSVSLAAFLIRRKSGQNFN
FDRLKNGAYFLVFGPFLSASIAGMLGGGVYVFLGRTDTSYLSLWQIWWFGDALAMLVLTP
LIVVLARWMQAGFPHFKLHFLLEAFLLWLVVIIIGYQSFNIESSDNAYLFFTPVWLVFLG
IVAAIRLGVAGASTTVALITAFAVEHLLRGTHPLIVNMPQNALLLTQEYLAIIAIVSIGL
ALLIQEIAEQRDELKRHENALKAQNQFLEERVNERTLALKEVNQALQHANDRLAKSAATD
ELTGIANRRHFLSEVERELQRLRLDGQTASAIMIDIDHFKLVNDNLGHDAGDKVLRDIVE
PISQAIRPRDLFGRMGGEEFLIFLSGADYDMSNAVAERIRLAIESLTVNYREHQINITAS
LGVAQWDGNSHLDELFYQADKALYQAKNRGRNRVFNITNIESENRSSRGSNHEDHFELP
>A0A1E3GQ85|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MATSIEGQSVSDIRIDGIQSFGCLIRFDSLLQEVLQVSANLQEKLGISIDKALTSAPKDI
LGSKLQQRIKQSLSNNLRLSAALIINRQVLGTYQRFYVMAYRSDDSIIIEFEPLSRSGEQ
RLMPIVNEWLSRLAQVQQIELLQQMLVQSIQAVTGYDRVLLCQFDSHWNRTAIAEVCRNP
SRSLLNYRFPASDIPAQVRNRYVIQPLRNIPDVNAQIVPLTPTSADLDLPQLDLTAGMLR
ALSPHHQRYLREIKVAASLSIAIAGEQQLWGILTCHHFTAVEVSAAERDAAFNLVQMATQ
RMFLLQARQQATFLQQVLDSRELLSTERDKVVQPKALLEKYGKNWMQLFNCSGIALLYHD
QVSCTGETLDSYELDIVGKWLSEHNGNKVCWACDQLSNSPLDKLVNLRSRAGLLAVPLPI
EQNQSGWLLLFRNAKKVQFSWVGKKQIIEAETSNPLHRVEERGYEIWVETIDTEAPRWSV
KEQHAAQDLAEDLAVAITVHQISRLNTELQRANKQLKEIAHTDTLTKIWNRYRMELAIDA
ELAAAERYGHPCSILLFDVDRFKSVNDTYGHDVGDQVLTRLAEEVQSKLRISDNLGRWGG
EEFIVLASHNSLEEAIALAERLRQHIETVEFKTVGKITVSIGVAEAIPGKESRRRLFERA
DQAMYRAKQSGRNRVEAASTELSAS
>A0A1V5G1W3|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MSASHASAIEDRLDQPPRSEVVHCDVESSALWQRFEIAAPDGGWKGEPVAVLVHGGPSDR
VQISQGARIYCGQFGDAARMDSRFHTGVGGVFVPAAGSAQPIVVHALGPDIALWPVVLTS
GPPAAVQRQDSYRFGLRIGVLSVMFSVVISSLLAFLVTRESALLIFALNSAVVFVWIALM
TGVSSFPGAWLPVGEWRVRLLIGVPLLMVVGTTTLMFSGRAQRKRHIWLPSLAVAMGLVA
VTVLLLSLMMDASLLAPLAMLVEIVSMAVLGGVAAFSVWRFLKARSTTAMGNFVALLPVL
FVGVVGALMGGAFVSWKIEWMVGTVAWIGVAASAVLLLRLGNIRRQRDTMRRLAETDSLT
GLANRRAAIQELERCMAESRRTRSSLGLIFVDIDHFKAVNDVHGHAMGDAVLIAVSERLR
SLVRTSDTVARLGGEEFLMILPGADETTCVRLGQRCSEEVLGIELPCETGLVRVTISVGV
ASSDRHPDAQAGQLLQLADKAMYSAKRAGRNRVISASGL
>A0A8E2P1Q4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSDQIIARVSQSLAKVQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFELINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A398Q731|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNSQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8H9A926|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1S9IUA8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MDIIKKIADETLMPVSKVSAFIFTAPYRYKVYPIPKRNGGFREIAQPSRALKFMQRIVIA
ELEKVLKVHENAYAYVKGRSIKDNVEKHKRNSYILKVDFCDFFNSINPYGLELCLKNNGL
DSLLSSQELLNKLFFYKKSKRGALSMSIGAPSSPFLSNAIMYKFDSVISDMCSNKNITYT
RYADDLTFSTNEKGILYEFIHEIDKVLEEIDSPKLKLNDKKTIFASKKCNRHITGIVINN
EEKLSIGRDKKRYLSSLIHKFSLNALNEEGVEHLKGYLAYVNKIEPSFISRMKRKYGVEV
VNSIITFNPL
>A0A398TPM9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8E2TDU6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAKELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPGD
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A8H9E182|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
FNGLRYDIWNGVTVIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIF
SALRVTKNIAHRDPLTNIFNRNYFFNELTVQSASAKKTPYCVMIMDIDHFKKVNDTWGHP
VGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGD
NPEYAIPQKVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A2N9LIJ9|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MAKRKAQEQVANTSHWHLAPASFLILGFVGSGLPAGNANSWYWIAAMALNVVARLTIPVE
PVVLARRADTPMSPAVRWRAVSYLADALLWAGLVISINPLTGPMATRVGGSLAVAMLLSA
LSSASRATPLGLALGWTIPVLAMAVHGSSGGVIAVGLMLWIASVVWLGATRPVAPPRRLA
TVESTLPNSSGSTRRGVQLAIQTSAAPMIAIHEARVFEINSAGAALLGQISFDCIGRRIG
ELAVFDPPNALDLAQAARDGPVRAIMRSVTLPRGDPIDVRIRVGRSRSGERIAVLAMDAP
PVAIAAPVAPAPSPEALVRPPTRPASLGPPGARGSGAAAEGEPRVVAGQFATVPTGEAST
QAAGALAAGPAGGPEHRAPAKPTSESVAPAGAASAVPAGAQAALQLPDLLAKLPVLAWVV
DGDGRVVHTHSAEVRRWGMKIGATMRPRWWDTFVYQARSREAVLKALESAVLGRPTYDLL
IERASPSGGRLALRSHIVPVSWPDAQGKEQPSALVLDTIASAHELLENDRVRRRKDHYKS
LVEASPNLIWACDASFHFTFVSRRACRELYGYAVDDLVGVSIGVLLNPGADQTAARRALL
ALREGRVMRDVEMSHVTKDGKRIVVAVSAAALAGSGGRFSGAVGIMVDVTALKQREASLA
EALRVERTVLDSAGQALAVIRDGVVARCNEAFLQLLRRSASELQGLRIVEIFAERGDWAA
ATADADRASLSDQAVVREIKLRRSRAPALDEQTVWCQLTLRSVDRGEYVVALADIDSLRR
REAHALFDARHDELTGLANRRLFAERARTALATSALRNSGCAIVVIDLDRFKQINDRYGH
QAGDEVLQEMARRLQRVVRPQDTVARYGGDEFALLIPDAGARRDIEAISNRILDELARPV
RVGGRIEESLSASVGIALAREQGREPSWLLSLADRAMYEAKSAGGNQAVFAPLADSISES
PGLGMPPAVGRAA
>A0A1V5LR52|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MNLFNSEQPKKNNMPDRTFIRDGVFHRQLSNVRNQVWSDGKVKALEQANAPGERQAGDIF
SHVREGDEEITLTSDDLDLIAFYDGLPGCYNFRYLFRKLTREVKRSKRYNRPTSVVMVGV
DGFDKIELGFGNLAADTVVFSVIEFLLAGIRSDVDMCGRLADDRYILVLPETPGRGATVL
ADRLRKRFEELDLRHNWHKLPVTLSFGVAYFPGHGDDPRELIARADLACEFVQSRGGNGF
AFAPEA
>A0A730K4F7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 43:z4,z23:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDYSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A212JL57|diguanylate cyclase|EC 2.7.7.65|uncultured delta proteobacterium|TrEMBL
MDQTFLFPLYSLLDIHIKTLIAVLFWGNLVAATLVYSFIALTPRSGHGKHSYSYFTGKVF
QSLAFLLLFFRDQIPDILSVNCGNTFLFIGFCIEAGSALEAIHADSPKVRKLCIGITAAC
VILFNAAEVIQPGDPAFRVFIASICVFLTLCVPTERLLRFPGPSQFKRAVGVFYLVFLAM
LLPRALAAMLSPFGLHSNTLVQALTFLSLVLLLVFSLAAYLFLLKEESDKALSEMAAMDT
LTGLPNRRTFFAKAQIAFAGHAGGNTPLAVLHFELDDFKNVNAIWGHSFGDFFLKSFATA
LKRSLRATDTPCRYSNGEFLAILPGADAEQAMAIAKQALVGLKKTFLERRTGLIFTVSGG
VSSGVPAPDSTLAEYLRQANQALHIAQTTGNNKVVLWKK
>A0A1D4GYX2|diguanylate cyclase|EC 2.7.7.65|Staphylococcus caeli|TrEMBL
MFEAIIYNISVTVAGIYLFHRLQYSENRIMIFSKEYVSVLMTIVALLLSAYPVPLFNEYA
LYLSFVPILFLGRYTNMFYTVLSAIVVGLVNLLIGDYTFITAIVLIVIAVIVGAIGPFLK
QNDIISLQILNAITLVIFAILSLISPYYDVTEVLFLIPISFVLTITSSITFVDIWHFFSL
VNRYENEDKIDYLTGLGNVKEFDRHLNETARISEENNQSLGLLLIDIDGFKDVNDSYSHK
AGDAVLRQMAQLLKNYVPQQFSIYRNGGEEFSIVLYDYTLDQCVKLSESIRGGVEQSTFH
LPNKEVIKLSVSIGVGYLTTEDYKSQRKVFKIADDMLHMAKNEGRNQVMFNPIVKL
>A0A3D1C0U8|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFALVDVNSFYASCETVFRPDLKGRPVVVLSNNDGCVIARSAEAKEIGITMGEPFFKQRD
LFRRYNVATFSSNYELYADMSNRVMTTLEIMSPRVEIYSIDEAFCDLTGVRNCRNLDDFG
KEIRATVLQNTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNVDRQRRLMSIVP
VEDVWGVGRRISKKLNAMGITNACQLADTSTWVIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTEYEQMHQAICSHAARAAEKLRGEHQYCRYISAFVKTSPFAIN
EPYYGNSVSVKLLTPTQDTRDIINAAVRCLDNIWRDGHRYQKAGVMLGDFFSQGVAQLNL
FDDAAPRRNSEKLMEVLDQLNAKGGKGTLFFAGQGIQQQWQMKRDMLSPRYTTRFSDLLR
VK
>G0F196|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MSAHQPARGNGARPTLYSVLRRIHLGVALIAVFTAGVSLTALGLTALRVYAEHNVRLVAR
SIAYTLEAPVVFRDQAATGETLAAIAASEDIARATVYDHDNHVLAEWQRPGQAPLTGLRH
VLSEWLSMGVVEQPILHQTQPVGMLRVSGNARNLLHFLLQGALGLLGCLLLTAVGAHYLA
SRLLVQIVEPLRNLMRVAHAVRSKRDFAQRTPPASIAELNALSEDFNGLLDELQTWQNQM
QHENRSLAHRANHDALTGLLNRAAFVEALEHAVRHAAANDEYAAVLYLDSDDFKNINDRH
GHAAGDAVLVAVAQRIRTSLRASDTVARIGGDEFAVLAAALRAPRDAIHIAEHILHAMSA
PIDLPDGSTVQASLSIGLAVFPVHAQGSQALLHAADAAMYGAKRRSGGTWQSAEPRLDVT
Q
>A0A377TQT5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MELDIINQREALKIANKELEKMAAYDSLTDIYNRSKFMSLFNEIKVDSEKYQSPLSLAVI
DIDYFKSYNDDFGHQEGDLALKIVATSLTNSLTEKGILARFGGEEFIVLLPNTTESECVA
KCEVLRKCVQGILTLKRTITISIGAVSIYPNEGCNISFDELFKIADTKLYDAKKSGRNRV
KNHRID
>A0A1V5R190|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MSRPPDEDPELLPPTLPVTAFADLETLLRSRGAEDGQVEPCGWALVVYAGPQLGRLFPLA
MGENVLGRAPGTAIALPDEEVSRAHACLRLAQGSEGDQLTLVDLGSTNGTFVNGQAVAEV
RSLEAGDRIEVGGHVLKLVALDPLERSFHETLLDQSTRDPLTGLSNRGAILSELQNRFDL
SRRHGRPLSVVVADLDHFKAINDTHGHGAGDLVLNTFGELVRQNLRGTDLAGRIGGEEFL
IVLPETELAGALQLAERLRASLERQSGSLVEGLLRVTCSLGVGERSGEDRDAGALMGRAD
RALYEAKRGGRNRVVSAGSKRH
>A0A4P0Y4E7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVNFID
DLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLST
AGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNRS
FFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDD
AAARIGGEEFALLLVNTG
>A0A378AQS3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQLPDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRG
FLTLAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESD
ILARQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWAASNTIPPAI
PVSTRWWPPLTA
>A0A2Z2P020|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MTDAPRLGLQSKLAIWLLVVLIPVVVAGTACLYTINLRLSQRIEADLMNTRRLEAARITE
ALANYKSDVESLVAGRDVVALVSRIDKAQRDPSVSGITIDRYNGFDTIDPLSDKPLQQLV
DGLDEKARSVGSEVVELKLSDMQGKVLGSTAGFAWEPYDRAIVAKAIAQQKTLFGNAFRA
NSGEHRMGMVSPVYDLRREIIGVLQVEMRLEPIVGLVVAHEGFGETSEAHIAQPTVDGDA
EFITLLRFKRKAAFNKIVPKSKNLPINWSLESPGGQLVHSPDYRSIDSILAIETLPETGW
GLVVKIDAVEAFQPVAEVQRIVLIATIALMMGVVLGWILFLRPLGQRMQRLSKAADRIAS
GDLHSAIGDSSVDEIGMTSRSIDKLAKDLLEDINRRAHAEQQLLYRAHHDELTGLFNRMR
GNELIELLDQKRSKIKDRAILFLDLNGFKAINDQFGHDVGDQILVAVAKRLKEIIGGNSA
LIRWGGDEFVIVALGADARNVHDIIERLNKMFSEAFFLPSGAHNVGCSIGLSAANDRSCK
LDTLLIEADARMYEDKQLRKAS
>A0A517VEK9|diguanylate cyclase|EC 2.7.7.65|Gimesia algae|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKNPDTDIKEVIETIKADPAITAKILKASNSSFF
SLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITHGPLKSRFDSYWKQSIIQSAAAEL
LATKAGFDLKYDSFLIGLLQDIGHLAMLRSIPTDLLSVLEQAEKEQRETVEVESAELGIN
HTEVGVKMMERWQLSEQFQTAIQHHHDSVAQLKTLESHPDFNLIIIIATSAAIGDYFCSP
NSGLALQKLQDLTSEFYNMPHDDLHGFLEQVQARFEEAAQIFAVNMDDIESPFEIMAKAN
EQLVQMTMKAQVDTTQAFARQAVIEEQKNKLESENKQLQSKAIHDPLTKTYNRSYFNENF
EKELYSCSRTAQPIGIIFSDIDRFKNLNDTYGHQFGDLVLQRVAKVASDSTRRSDVFCRY
GGEEFVIMVNNPSEKGIHDLAERLRKLIENEVIEFEGTRVPVTASLGAVVGIPPRDLTGF
AERLIAEADEAMYESKENGRNQVHIRSIITKDDQELHKLIKRCRFSRWLVTKAVFDIPTI
SKALLKCPQQQTQTRIGELAIAEKMISEDGVSKILELQQLKGMRFGEIAIQQNFLTQEQT
AYLLALQVEPPIVLGKTLISLNLLESAQTAELIKQYLAEMKPCSIPAGEHQNQLANS
>A0A3M2RL09|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MLGTRFRIFTRFLILASLFVASEAIAQNPCPTLVANDADARQTLNNYLCYAVTNPGEPAH
LANGPDNLPSSLKWQPAGGHDLVFSHTQATYWIKLTVTNTGTQQSLWYLKLNYPLLDEIT
FWQTRETQTDHSSAPALTTGDHHPFTSRGIDYRYYLLPVTLTANEVATVYIRVHSSGALN
VPLSLVTPDQAIEESNHLTLIHGLFYGALLILAIFNLLLYASSGTRYYLLNAFNTASMAM
FLFAMGGFANQYFWPDNSQLANLSIPLLLAVTGLAMTLFGWSFLEVPRRTLSGRTLHVLA
WTGFGLLALTLVIPYTKSIVINTVFVLAAIAILTVIASLRWRQGYQPAFWYLAAWMVMVV
GALFYASAAFGYLGDYLAREVTMQAVVGAQVVLINYALVQRWRLLNEKLLNVEHQARSEL
EIKVHERTAQLRTAMYRLEQANRKLETLSLKDALTGLHNRRHMDNLLPELCLEAQRTGKP
LTLALLDADHFKRINDTWGHDFGDTCLRRIADILTEHVKRPRDVAVRFGGEEFALLLPDT
DTSGAVRICNGILETIRTTPIHTPINEAVTLTMSAGIAEFAGHENAQELFQSADEALYTS
KHRGRDTLTCAGTVPQPPA
>Q32B88|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTFLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSIPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPTTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSGWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A0W0SCU3|diguanylate cyclase|EC 2.7.7.65|Legionella brunensis|TrEMBL
MVFPVVMIVLGIVLLISGAYLINKLLQKTNHYRRQWFSYLAFIAVFILSYSASIFYGLLV
DPHCLNNFYASVLLLGATYIYSSCRLMTNTIQKMELMDDFKNRYEVLRHHATYDSLTGCN
NREYLFEMMNTRFQQVKMNEGSVIVLFIDMDRFKTVNDRYGHEVGDTTLHMFGGLLRQRL
RRDDVVARYGGDEFIVLMENTSMDEAKKIAENLITVTKKSLKEGTLSELNLGCSIGITQM
NHHSASVNTVIKEADLACYAAKQRKINGSVCVYNSMITTKNNAINFSGNQITP
>A0A808IFA4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. Crenshaw|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIQTPLAFDVLQNAVSRFSSVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFNHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASTLRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A4U9HF05|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MTDDLTGCLNRFAILQQIAVALEASQRQEADSYFSVLMFDLDFFKQINDQWGHLVGDAAL
VHFCDCLRALIPPDAALGRVGGEEFLLLLPKTRSDAAVQLSTRLRQALTVTPLNVGTRML
TLSFSAGWWR
>A0A1V5JCC5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MQEEILTTYSFDPRVLLIILTGVAIILAVIMNLILLFRKTYPGFGLWTMGITAFALGWNL
ILLRNVFPDIFTIVLANMLFLTAAISFLEGIKIFRGKRTRKTLFIAIIFLYTVFQSYFTF
ADYNTSARIILVSFISAIICGFIVFELLSNIPADLRITSYLTAGVFILYSTFMFIRGILT
TLHPSPQNFLEPNIITAITLLLNLFFIIAVTFSFIMTNNIRMEIELRGTMTQLQKMATTD
PLTGIPNYRFFFQAGEQEMRRVYRYKNHLSVLMLDIDHFKKINDKYGHAVGDTVLATFAD
VCKKCLRDIDIFGRLGGEEFAVISPQTDIIGAKILAQRLRTNIEQAEIKTEKGNVRITVS
IGATELLPQENNFESVLKRADDAMYEAKRKGRNRVVAL
>A0A212LGT9|diguanylate cyclase|EC 2.7.7.65|uncultured Pleomorphomonas sp|TrEMBL
MTARILVVDDILVNVRLMEARLTAEYFDVHTATSGAEALAMLDNAAYDIVLLDVMMPGMD
GFEVCRRIRANPRTTQLPVIMVTALDQPADRVHGLEVGADDFLTKPVSDTQLITRVKSLV
RLKQLTDELDLRANQGSVAFDRAMTYADLTARAPGRILLVEDRRSAYVRIAQALAGEMAV
DIETNPQEALFRAAEGDYDLALVSTSLDDYDALRLCSQLRSLDRTRLLPILLIADPDEDS
RLARGLDLGINDYLVRPVDTQELTARCRTQIRRKRYTDRLRASVLQTMELAITDALTGLY
NRRYLDSHLAALVERTIEKKGDLSLLIVDIDYFKRVNDTHGHDAGDEILREFATRIRRNL
RALDLPCRFGGEEFVIVMPETDYGIASIVAERLRTKIARDPFAIHGGAAFVDVTISVGAA
YILHDGDTPESLLKRADNALYRAKAEGRNRVVLAAA
>A0A4U9IRP2|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MGIGIWSMHFIGMLAMDVTLRLNYSLLPTALSMLIAIGASLFAIWLVSRDHFRRRRLFTG
AVILGTGIVAMHYTGMAALQVEPAIVWDMRWVALSVVIALLASLAALWLTFRLRRDAAQV
ALMRAGAAVLMGVAIAGMHYTGMMAAQFPVQAHMHHQGVNGSWLAVLVSVVALSILGITL
LVSMFDARLQARTALLASSLAEANRELAQLALHDTLTRLPNRVLLEDRLDQAINKADREG
KLFALLFMDLDGFKAVNDAYGHDAGDKLLIAVTERLEQPLKGQYTLRPYWR
>A0A2P9EVM1|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. MA5143a|TrEMBL
MDPQTSSDQALRASEQRRLRLQVLGLNSVEAEATFDRVARLAASFTRSPLAMVNFINDER
QMFRGMYIPPSSPGEKVGPDSPAVPFDLSELSREAPGDYGFCPHVVAQGSQLALDDVFDY
PRFKGNPLVNDLGVRSYLGTPLRDNTGMILGTLCVADFEPRQWDRRIREAMQELSETLLA
DFKLRDSLLAQQQELFAVFDGAPFPIMLTEGPSHLLRYANGRQGQAFGMVPQFSPGRLAL
PHLDAVGVFSAMDDAFHSGRAVTLSRARLGTYDYPQPQEFDFLCTPVRTSPGAPISGVLT
VAMNVTGQAFAGPEQQGFAGPEQQAFAANVQERFEQLGAGAFPGQRP
>A0A6B8N678|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MEAKILNSVVEITEQRNSISLGHCLVATLLEMMPIESISLTHYLSNTSIVVAKVFRNSKQ
EEYQWTYDQAPEQCYMHDHKESAFNVTKPQTSSYICRYPIPISEESSALLQIETEADPVK
FELLIDGFAKIYRNYLMVLHESERDKLTGLLNRKTLEERLSHCFNLSVNQDSGLYAWVAI
IDLDLFKSINDTYGHMIGDEVLLMFSQQLQNFFSGSEQLFRFGGEEFVVLLPPQEKKQVL
KELELFRRHIESFRFPQVNNMTFSCGVCAISRHEYLPTILGHADVALYSAKEHGRNRIEC
YEDLILGATEPGDNDHLDDVELF
>A0A564TLR3|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MLRIPTGKTPLVTKEQGIAQLTDDGRHHQYMVYLLFSGERQYGLLLCEVSVRDIPFYYVV
SLQIGLALHNYELNRIEAMRRQQLCQDMERIREQNRELGMKSAYDQLTGLLNLRGFTDRA
KKICTEERKQRAYLLYGDLDHLKEINDTWGHAEGNFAIKASADILKNCIRGNDMIARIGG
DEFSCLIFSDGESIDVKLKNRIVQACREFNKHSGKPYYVELSIGIECFELEKYEELQLAA
VKADQKLYEAKKGRRKSIRRVEETEEE
>A0A1C3JSX6|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MQVFRYIFRADLRRLILLLTIGCVLVTFGNSYQAIYNVQRKLLIDNTLEANQRYAAKVAE
SAEMLLTSAQDSVAFSAELLAGNFHFSGKPEEEIYRLVEQSEVFNSAIIVNNEAEVVATY
PEGILQKGFVLPENTRQSYYERKPLITNPFHSVSGNTLISISHPIWGEHGHYLGYISGTI
YLNKNGSLSRLMRDHFFTDQTYLYVVDQLGELLFHVDPNRIGENVSQLPLIKQALGSAEG
SQETINSLGIEMVAGYASVPSANWGVVVQRPKDKVMKSLNDQMLNVFWASLPIALLTFIV
IWVLAYLISKPLRQLARSAANVNDVDMQRQIVSVRSWYFEASQLKIAVLNAIGLLNDKIH
KLDVDSHTDPLTQLHNRRGMQRLLDDFEAKHLQFSVLALDIDHFKLVNDCYGHDTGDLVI
QELAKTMQNFIEDSDMVCRVGGEEFLIFLPNTSGESAVSIAESLCEHVANTVMPKVKRIT
VSIGVGCVENDIDMADIDMAIKQADTALYDAKNAGRNRVKSMLNSQGLKL
>A0A485DC33|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MGDEVLVALAKTLNRLSRPEDVVGRLGGEEFAVLFLAASSDEVASYTARIQQEIRKLTFH
TTGDITFKITASFGVSKGWQCRCRN
>I3X7N8|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MTARILVVDDIPANVKLLEARLVAEYFDVLTAGDGRSALAICENTPVDLVLLDIMMPDMN
GFEVCERLKANSRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKNVSDELRLRAQTAHTIGLQELARVDRPDELGNVLLVDGRASSQERLLRALKPIAEVA
VISDPQAALFEAAENSFDLVIVNANFDDYDPLRLCSQLRSLERTRFIPILLVTEQGSEEM
IVRALELGVTDYIMRPVDPNELVARSLTQIRRKHCNDRLRASVQQTIELAITDDLTGLHN
RRYLDTHMKLLIDRASARGRPLSICITDIDRFKLVNDTYGHDAGDEVLREFANRVRATVR
GADLACRFGGEEFVIVMPDTTPEMAAIVAERLRLMVEGRAFGISQEDTVLTITASLGIAT
LRPHEDTAEALLKRADTALYQAKNNGRNRVVAAAA
>A0A2H5WPL1|diguanylate cyclase|EC 2.7.7.65|bacterium HR14|TrEMBL
MRWRFWRWFCEGEVEPDSPATEALAATLECFGRYAFDLPDQRAREIQSRFQKLAQQARDG
QVQGIPERVCEHRRAEQAFVAQSLNDLRDLTWQLISGMARILQEDGEGDRAVRQQIQKIA
ESPPTEVQVLKQALTALTQMLEERERRHKQTLQQMQSQMGQLLQELEQARKESHIDPLTG
LYNRRALEHHLQSTVELNRLFGYSAALILIDIDDFKRLNDTWGHTTGDEVLKAVAEVLVR
VCKRKGDFVARYGGEEFAIVLRETTLKEAKAITQKILDAIRREVFQLPDGNLLTVTVSAG
VSVLQEMEEARAWLERTDQLLYAAKRAGKNQLQAA
>A0A379JRB1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MAAVMDDQGNAVSELEELTLALLHSRAEVERLGEREQLFSSLLGSVNAVLWAFDWNEQRM
IYVSPAYERIFGRSAALLLADYGEWRNSIYPDDIDYAAESLAKVLEAGAVESREYRIIRA
DGQLRWLSDKCFVSPRMGSAEQGCVIVGIAEDITEKKRLEGELHRLATTDVLTQSSNRRH
FFECARSEFEQARQFGSSLAFLLLDLDDFKKINDQYGHQVGDQVLQRLAQCGSHALRRGD
LFGRIGGEEFAALFPGCEQDVALQIAERLQREVQRLGFQHEGQHFGITVSQGLTVMRATD
ASLDGLYARADAAMYTAKRQGKNQIVLG
>A0A8E6VVC2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Shamba|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A517YYT6|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MNPKILIIEEEARLLDQMRDALEQHFGSSCVQYCCSVFEAKEQDLLHVDLVLTSMDLPDG
SALDVVENLLVKRNDLPIVVMADESIIELAIQAIKQGAYDCIIRGGDWLTGLPFIVEKNL
AVYIVKMENEQLRKRLERTLDQLRVKNEQLEMVVEKLEDIAATDPLTGLANRRAFARALG
RYFAASTRDDTDLACIMIDLDGFKALNDTLGHQNGDKLLQHTSRVLQQFLRRSDLAGRFG
GDEFVLLLPNTNQQRAIQVAERIQDEFRKEISRQIMDEHDQIKLSMSMGLATLRVSEAKS
PQALIECADKTLYAAKRSGKDQLLVYQPKRTAKV
>A0A896Z252|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A378IQG0|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MIPPDIPENEAGRLATLYKLKILDTEQEERFDRITRIACKLFGVPISVISFLEAERQWMK
STQGFDIKEAERKTSFCGHVILSDEIMVVEDATKDKRFHDNPFVLGKPHFRFYLGCPLKI
KGYNVGVICLIDNKPRARNEVDHNVIYDLAQMVEMDLEQLQVSITDELTGLSNRRGFLKL
ASYLFQKCQRENQLFTLLFFDLDQFKSINDQFGHAEGDMVLKIFANCLLQNFRYNDVIAR
LGGDEFCVFCSGLNQKDVSGIIQRLKDSLKSAKTKDYTIQFSVGIIQYEPKQHRTLGDMM
ALADSEMYVSKRGNSSL
>A0A378KL99|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MDNLDQYKAKLLESTNDVVIITDNNLENPVIKYVNKAFEKLTGFTKEEAIGQTPRILQGP
KTDKNTLRRIKRAMVLKKSVNYELLNYSKNGREYWLEFSVIPLLNERGEVSYFGAIERDI
TQQKYLHNNLYEMATKDYLTGAINRNRFYEVAAISFASYLRGNFNIAIMVIDIDNFKFIN
DTYGHKEGDEQLKLVTSVCFNNIRQTDYLCRFGGDEFIVMIHGLDDKTLKNKADTIINAI
SKSQKSKVSVSIGATLVDIKDTNIDDLIARADLALYEAKKKRKGKAIVF
>A0A822TK83|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHSAPHC
>A0A840RGM4|diguanylate cyclase|EC 2.7.7.65|Silvimonas terrae|TrEMBL
MESNMVRLAESASAARSLEELAKPLLELLQNLTDFESTYITRIDSGMTTQLIEFARNVGK
LEIPEQLAVPWSDTLCKRSMESGCTYTDDVPGLWPDSEAAKALGIQSYVSAPIRSQTGTL
IGTLCAASTRQLPLPERARSSLHLFSRLIAQHIEREKLLEQLQESNTRLTRAAMTDPLTG
LPNRRAVIEELARMLAVAGRERGTVLVGLVDLDHFREVNETQGHVRGDHLLRDLATHLNR
AARDYDLIGRFDGDEFAVIGPGPASRPEAQLLTAELASRYTSAAANVMAASVVFIVADGT
MSADEALQQADGEMSILKRGKGGKLN
>A0A7X2FZC6|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium HT1-32|TrEMBL
MTNDYAGDLLDALDTAINEHMAWTLDWFRAALAGSGFDSSDLSDSAEETDSFSRWISHNS
SSPLLDQPAFHALVQLHQDARTAGRDLARRIEAGQEVGAYELAAFSDQLQQFHVSARRLE
KAFGAAASELDTLTGLYNRTAMRRELERERERSLRTGLPCTIALADLDHFKAINDDHGHA
AGDRVLQMAAEIFSQNVRPFDHVFRYGGEEFLICLPNADLEQADIVLERVRTALAAILVD
IGEADPISVTASFGAAPTCSDIDLNETIELADKALYQAKETGRNRVEISKG
>A0A0M2WMZ6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MIAITRPLQRLARRLYSLSLVPLFALILLLALWAAVFYQVGQERASAVRDAVAVSQSLAR
TLADHTSFTLRQTDHATQLFKLKYEETDGSLRLNEFTRRQGLLDSVLPSKLELPIALIDA
QGNVVDSAHAYLPENLATQPFFRALAANASDTALVDTPMLDADGKRWTIRLARRLNDAQG
RFAGAIVILVDPTYFVDDYDRLNLDEHGALMLVARDSGLTVGRIGEQLILSDRIDFRMPG
PPQHAAEELLIEPPVDATSRIYSYHELPRYPLLAVVGVSRTVALARFEHRRIVYIGALLA
ASVLIAGFTTLLMRQSARLRRSIRQAKETQALLRAAHQGSLDAVLLLKAWRPAPGKPVED
FTFADINERAADMLGKPRSELLGQRVLPQMPLLRGERFFQRFVLVMETRQPLEDEFELPL
ASGGTRWLRHQVVPIADGVAVTSRDISARKHDELALQDNRSFLQSLIDHLPVLVYVKSAR
PENFGQMEVWNKAAEDITGHLAADVIGKTDFQAFPPDFGLHDAEDDRAILAEHGVIDHTE
KPLRLLDGSLRYLRAVSVPVFDERQQIEHILCIAEDISQRRQQELELRQKQAELAAVNDA
SPLGLVRLDRQRRCTYVNRTFESITGLPRAAALGAGWTSALHPDDYPLMHVALEQLTRSH
APFQSTLRYLQRDGRLVWVSVKIAPILIDGQIEGYVGTLDDITTLRESEVALLESEARLR
TIADTLPAMIAYIDADQVYRFLNIAYEREFGLRGRQALGKSVRDTVGEARYRTVAPYIER
VLAGETLSFEEEDEKEGIERCLEVIYIPQIGEDKLQVVGFHVMRQDITVQKREKQRLLKL
AQVDALTGLSNRAGFQQKLSDAMHASRQQQHLMAVMYMDIDRFKPVNDTHGHGTGDALLR
AFAQRLTHTMRATDIIARLGGDEFTIIMEQITRPDDAAVLAEKIVAAMQQPFELDGITVR
ISASIGLAFYRDEDISPAVLLQRADVLLYKAKQDGRNTYRAGALTA
>A0A359KJ34|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp|TrEMBL
MPNPTSAVAASSRVPEPALDPQSLERLRALLSANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRNWLIDLFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADELAADPEAFALLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRAGLMEWSQKTLFRILGSGGVDGAGALGASPFGLWIRHRADFLFDGSPHLARLNATME
RIDSELLPRFTPDAAPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHQ
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGV
>A0A447LP52|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MPLSEYINNRDGVAGLRFIRRMYLMRMLGTLLCFIPILSVLTEHRLSLGWILLLGANAFV
WPTVAFVIARRARQPLKTEYRSLVLDAAAGGFWIAMMSANPLPSVTIASVLLSDRLAAGG
IKLLRKAAVALITGFLLCWLVRGAPFEPTISQRTVYATLPLISIYVLAVSVLTDAIARKL
RLKSEELGRIAMMDPLLDIANRRVLEPRMFHVLNTVRQRHTQSALMFIDIDDFKDVNDRY
GHKVGDSILVAVADILRRCTRQQDTPARLGGDEFVVLLPNTSVEEASAIGEAIMGEAAIL
QADHGIPYHCSLSIGIAFATPDMTSATEWLKAADDALYTAKRQGKNCIFLC
>E3G434|diguanylate cyclase|EC 2.7.7.65|Enterobacter lignolyticus (strain SCF1)|TrEMBL
MEMYLSNMTDEWTNLVENTAPRIRSLASEISRLHAHNLSIEFYNTVLTDPHAEEFLSNEQ
VERQLKAALARWITDVLSGKTEDVNRLVALQQTVANVHARIGIPVELVEMGFRVLKKLFS
QVIIDSECDPSDKLQVYHYVMNSIDLSMEVMSRAFSFSESSTTKEDENYRIFSLLENAEE
EKERQTAALLTWEREVVYKVMLDVGPERSLPLNQSDFGLWFNHKGRHYFSGFAEVGLISR
LIQELDGFFSHTRDTAKAFSDKKQRGNFLLKVRNTVSQIMTLLRELFEEVARQEVGIDVL
TKLLNRRFLPPIFKREVAYASRTGTPLSILVIDVDKFKGINDTWGHHTGDDVLRRISQVF
YDNVRSSDYVFRYGGDEFIVMLTEASGSETLQLAERIRRRVEKIKMQSPTGDAIPLSLSI
GAAMFSGHPDYEHLIRNADEALYIAKKRGRNCVELWKPTA
>A0A734HKE5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:l,z13,z28:z6|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379CNC4|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MNNNPLSAAEYDRLLDHRMHNKKLKTIAFLEKQEKTVNTVAGFTLIGIIGVCDFLMGYEI
AFSLFYVLPIAFLLWFTGEKNGLIASFVSAIVWLLADKASGHVYSSMIIPLWNTVIRLSF
FIIIVLLLSALRSSIQREKTLARMDNLTGAINSRYFYLLVERELDRFHRYGNPFSLVYID
LDNFKAVNDCSGHAGGDETLKSVVAFIQTHLRRTDIVARLGGDEFALMLPETNLDMAQSV
CTKLQSGLLAEMQQHGWPVTFSMGVLTCQDSAKPQSVDELVQRADELMYTVKHTGKNGIL
YEQYICAPKSTTSHTTDSDTA
>A0A1V5CTT7|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin050|TrEMBL
MGIDKRIFIIDDEKDLLFILKEFFEAHGIEAITYEAPPDLRAEISEKKPGAVLVDIFIPN
ASGFDILNNIRKIDSNLPVIMMTGQPDDEKRLESLRNGAYALLAKPFRSFEEVYHIVNNA
ANHYGEIQRTFELTAEIRKRHEHERLNLLELDFLKKLQLMIGETEDSSFVIKNSFALLKN
FLDFQVFAVRMVQGEDINIQIYPNVGPDTKLMECVTTSLVGKVPERSQMQTGDKIGDDGE
PAYNYMTVDISSRDTVYGYAGLYRMLPFNESEEAIFNRFCSNIALTLEKIRLFNEIKALS
IHDGLTGIYNHAFIVRTLEDEIERSKRYGSALSVALFDIDDFKSVNDTHGHLAGDAVLQR
LAELMKGSLRTIDIVGRYGGEEFLAILPETDGANGYTVAERFRETVEKEYFVYGGERIMM
TISGGVGRYTYGMDVNKLIKVADDNLFRAKREGKNRIVL
>A0A8H8ZBG2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALNCRLVLRKLTEAEPVIIFEGIEASATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7X2F8A7|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A6A9U4U9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLG
>Q6R282|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQDKTLAKLANHAAKXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQG
>A0A087BCI9|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium magnum|TrEMBL
MNSSTQRGKSRVILVVEDEPTLATAIAQRLTAEGWTARVASDGATAVQAALQLRPDLIIM
DVMLPVMDGLEATKRITAERPTPVLMLTARDDEADKIIGLGAGADDYMTKPFSMRELIAR
CKALLRRVDRARVIAKNSENEKILDFGSLVIDPAQRVVTLNGETVHLTPTEFDLLVTLAR
KPRSVLTREKLLEEVWDWVDASGTRTVDSHVKALRHKLGSSMIRTVHGVGYAFEPPVD
>A0A658XZS0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MHKFVFGGPIVAHILSSHYESYNLHIAELTNENGQVVWKASYVTIMIFMWLTLLSVNLYF
NGLRYDIWNGVTVIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFS
ALRVTKNIAHRDPLTNIFNRNYFFNELTVQSASAKKTPYCVMIMDIDHFKEVNDT
>A0A658Z244|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLIFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGCIRMDSRYVSWERLDHFDGVLARVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H9DEF7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRG
>A0A0H2V2X3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNTLENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A518BQG9|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla133|TrEMBL
MADPADLPFAQSKGLFSPDEMRRLMRSELARAKRYGFPLTCLVVGIDRLEALHDLYGVDS
KSAIYRSVLEFLRRESRAADMVASLTGDRLILIVPYVDRVGGLRLAERMREGARKLDFAS
DSRALQVTLSVGVAHARTREPEAYDSLFRAADDCQRLAATGGGDRVVDVDVLDAARDRPA
GDRRAGDSPERIEHERRQRADGPPADPNAVQVPTPSNPLAGLDPADLMEVVRDALGQLGL
DAAALAQAQAAAQTAAPQPSPAAAATPAAKTAPGEDRSEELDLQDRRISKLAKAVQAMQE
QLASLARGAGGDAGVASMGKVFGALEAAAGGGEGDDRRKELMGALFKANMALQKRRAAAD
DGA
>A0A1C3JB82|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MALPKTLIRLFKPYIILLTGGMLYLAMAQLEKIETAATEQSSSNIRIASSTIRSNIEATF
GKLYFLETSLGLPKTAPIGDKKFRELSDNILKRTPNFSDIVRYQPQSQQYISSRGLPLSH
EQIDSIKWNSIDSVVEDFYISSIYQKADGRWVFAVKHTAERLNEEIWIEFDLLHTTQGLR
DLKTLNHGYVFVVDRATERLVFHPDPKRIGSKSVSYHAGISHQLSQGETVGKHEYYYQDN
FKISVFDADNSLNWVFIAGTDRHDILTSSHQFTLTGLVLGSLLLLWIGANYLAYRLNVSL
SQLNKVDDLVSFKRELKSILDSFTYQKGIQFCLYQPENHAFSTIDYHGNKSTVHCDKALA
ERFTPDTMAYRSGKYADPLACKLKIHQRHYCIPLHSRKQLIAVLYVNANLPISQSILRMI
RDYTEVSLSNLLLQHQLSSKDLMTQLDNKSSFSIAIENYASEPDTYVALLDIDNFDHVNR
AYGEAVGDKMIKLTAESIRCYFPKPKGLCLARVGGKEFAVLFKANDVKDAKFQLDQCRVE
IAEKTIVTPDITLSLGVSVGYSQIEGETDSALALAEQAKLIAQQLGKNRVEGHIRAIAKA
S
>A0A1C3JGC6|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MRVNRHFSLTFVFGFPAVIAAMLLGLIGKNHFDAVEKDISSEFHRIEEVFKRTTKVVTAL
DYSFSNYYKSGNPLFLDHNKQVVDGLCQIWPIDVLLLADGKTSDIPSVDIDYMLIGQESL
CSESSDSYKSASEKIALAPILSFLSQLDEYHAGVHFIDTSGYVISSPEGFAKKLSKELLS
TIKSRPYWQKTANNPEQLTLTGPGYRFDSLDRIISMTIPVFHKGVHQGMLSVDINADKLL
ANSNEHLAGRIDIIDTTLATPVDSAAFYHEIKLDGVSSHHAMYYELDIAKEVEHFFVYEK
DSLIVAIIVYLFSVTIFFYVNSNIERGYFKDLAAKDPMTGLLNRRGLEAFWRSVEHDQLF
ALTVFDIDDFKSINDTYGHDKGDDVIRYMSRQISNSIRSSDVAARFGGEEFVVYMKGEDC
ETLMRTLERVKNAICTTSADIIPNGFTVSGGVCIVETEQSKLNFDEIFKYADEKLYVAKT
TGKDRLKF
>A0A6J7ZRZ6|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MILNNDYVQTNPELIHTQDGIQPHGLLLTLEETDLKILQVSQNAMKLYGISTTALINRPL
SDFLDKQQLFQIQECLITNNFNYYNPIRLIFHIKNKKIICDGILHRHQGIVILELEPTQD
QNVTFINFYHLVRGSICKIQSANNFKDLSQFLAEEIRKIIEFDRVMIYQFDQDNNGVVIA
EDKRQDLESFSGLHYPDTDIPEFARELFKQNWLRLLVDIDSQPIDIIPSLHPLTQKPLDL
SFSVLRSASPCHLQYLRNMGVKATLSISLIKKDRLWGLIACHNYSPRYVSYTIRKACEFL
GQVMAVELPYKEISEDYEYYREILKLVRKNLLNAPALETSFIQTLAQDQTNLLNLVKAQG
AVIRFGEDLILVGQTPPLTEVKKLIEWLSRYCHQEIFYTDCLPKLYPQAESYKNIISGVL
AISLSPNQSEYHLIWFRPEVIQTVDWAGNPQDGIEIEPQKQIKLTPRRSFELWKEIVQLK
SLPWKLVEIETAQELRNSLMLAALESSENQLRQSRELAQVTLQSIGDAVITTNSRGEIES
LNPVAEELTGWSLIEAKGLPLNDIFKIFDSQTHNFGENPVKKVLEEGCIFDFSDDVILRG
KDGKERAIDNSAAPIRSREGEIIGAVLVFRDVTQERELTRRLSWQACHDALTGLINRSEF
EKRVTETLKMLRESSGHHAICYLDLDQFKIVNDTCGHLAGDELLRQLSCLLQNQVTERDT
LARLGGDEFGLLLNNYSLDEAHKKAVYLCNLVKDFRFTWKERVFSIGVSIGLVGFDDQIC
DLATILSAADAACYVAKNQGRNRVHLYQVDDQDLIQQRREIRWAAQIPQALEEDRFCLYY
QPIVETNSTSKSPKHGEILLRLRDTSGQLVPPMAFIPAAV
>A0A0J6VIY5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MQGDDTDAAGASVESVATVEQRFRELFDLSSDGICVHQDGAIVFANATAVRWMGVPGSED
LIGRRVADFIPADILGKVESRLSGLHHDGDNAPPTEVSMSRSRGAMRDVEATSTRIHWHG
RPAVVTYFRDLTKSRAADLLRYQAALLDHVSDGVVGLSPEGTVSTWNAAAEKIYGRTAQE
VRGRPVHEAVGADVDADRLIDTLGVLHATHVAADGSPRSIGLTAARTASGYVLICADMTA
LRRAERHFEAVVTALDAGVVVFHPDGSAMSANPAAQRILATVRPVDAPFASNIPLVDADG
RALPVTEQPVWQVAHSGDPQVDRVVGVDCEDGSRVWLSMSTRMLSPDDPLRSPVVATFVD
ITAQKMAHERAEHEAAHDVLTGLLNRSGAFARIAASLRPDAVQRLSAVLFIDLDDLKSVN
DSFGHDAGDAVLVTASARMKDALRESDLIARLAGDEFVVLLMQGIEQEDLDRLIDRLHRA
ATDPIPYHDFEITVTASIGVTLVGLNDMRDALELLRAADEAMYNAKASGRGRTRYAV
>A0A087ANT2|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. gallinarum|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSSAATGEEGLELFTKGGIDLVLLDLMLPGIDG
IALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
LSGEGSGAADDDVPLVCGDISMLVGQHQVTVRGENVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRAKIEEDPAHPQYLTTVRGLGYKIADPE
>A0A2H9TAC7|diguanylate cyclase|EC 2.7.7.65|invertebrate metagenome|TrEMBL
MLLKELRQTTLFIFGSVAETPTRSFYFRLFFYGLMLYGLVLHTPVMANSNVHSQSFSLTN
SLHLLQPDEISQYPFLSTKDRASGQWYRIEMADHPLVSGYYVLDFGPIFYQQLDLFYPDK
KKDYQHKAFGISSGQQTIILDLHPKELSPLFIYIKSALPHKPAPILWPTTLYIQQAFSDH
GWHSALLALSILSLCFALYSCVRDQNSQSLYLTVHLAVTTLMMLTNQTPTLPLLSNLQPQ
ASWLLGFWFLSVFTGMLCYQKLALSPIHTLKLTFWSKITGITAGITLSAFLLFFPHSTAL
LSTSLGLLLTMLILTLSSLIYCAAQGIRASRQALMLSAILLLAYSIIFIKTQGWETGLPH
LVEQSLLVIQAMALLYLYRMQHKHLPRQVLAVSIDQKSMGKRTVFDPNLRQHLKKNAPLL
PESHLFEQILTTLQAVLPDTPALIVSRHQKTPWQIICQHTELAQLFKKKLPLLEHNLIPI
AESGQETRINLRDHLGSTYWLFPIENGDEYYTILVIAPVKLRYRTRQWQQATHLACHGRT
LFQSFRQTQYWQSRASLDPLTELLNRHAFMKEGQQRLLQDPDKNVIHNILFIDLDNFKHI
NDTFGHISGDKVLSNIAALLTQNTRQEDLICRYGGEEFVVLLPETDPWQAKLVADRILHA
IAQYQEPDINWQFSASIGMTASSQEAPSLHQLINEADQAMYKAKATGKNQIFMTHVCQDI
RIKGQQESLIRGN
>A0A381J5V9|diguanylate cyclase|EC 2.7.7.65|Clostridium putrefaciens|TrEMBL
MYKVSDSHNLGEEEMEGYKEKYEKSLEEFEIYQNFAETQIQMLSEKNIILEKSLDAVVNI
VEISKYINSYLSNENLIPMINDMIIGILGATYSSIYLEEEGEIIIKASNMEKAYLIFEES
FYIEKIKSGRPFILNCKETIFNTRNRGNMHSIIGVPINLRERLMGYMILEHSLCNFFTPG
HVKFISSIANQIAIAIENNILYKEIQKQINVDPLLGIYTRKYFIDFVNGKVLQNEDSNFA
IVMIDLDDFKKINDSFGHQFGDEVLLNTVKEIKNGLGIKDIVARYGGEEIVLYIDQGEDF
KSVYKTVDNIRKSIEDNEYSLIEDYKCVTATFGISFYPVDGGDIIKLLQAADRLLYKGKR
SGKNKVMYNT
>B2U417|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATRGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>C4YV54|diguanylate cyclase|EC 2.7.7.65|Rickettsia endosymbiont of Ixodes scapularis|TrEMBL
MTTILVVDDIETNIKLLTAKLLKEYYTVLTANSGKEALAILKKEKIDIILLDVMMPEMDG
FEVCKTIKTDPETTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSR
MKSLINELKLRNNTNALLGVTNIEMHDIFADKKILLINDDVVQAKNIKQMLLKITQNVKV
ISNSDELDIINEYTPDLVIISSMLENDDPLRISVILRGKAEISGVVIISQIDEDGMPLVV
KGIELGINDYFVYPIEESELLARIRTQLRRKQYQDNLRNDLEQSVNLAAKDGLTGLFNRR
YFDIHLKQMIEKANKESIKLYLLMCDIDNFKHVNDTYGHQAGDKVLTIVSRILKNTLRIT
DLIARFGGEEFIILLTDIDISKAIETAERVRVKIECMDFHIEDQIEPLKKTISIGVTEYK
KEESIESFIERADKAMYEAKTTGKNKVVKL
>A0A6N3EB16|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MINYKQLYNSLKSEYETYQQFSEKHMQELVNKNIKLEKNIDALSNIVEIGKYMNAYLSDD
NLISMINDMILGILGVTYSTIFILENGELSIKASNIDSMNIKLTSTEIASISKEEEFIMN
DENIIKQTGSAKVDIHSIMGIPIVLRSKFIGYILVEHKMFNFMTTELKIFLKSIANQIAI
IIENSFLYRQLENLTQTDSLMGIYNRKYFLDFLEKSIKENEDRKFAVVMVDIDDFKNVND
TYGHQFGDEVLKNTAKILKKWTEENDLLARYGGEELIMYISDIKDAESVFNKIEIIRKEL
ENSKVNCYGLSDSVTASFGMAFYPEESKDIKQLIKVADDLLYESKRQGKNKVLYSKSLKK
QTI
>A0A1A8TJ01|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MKITTSAKTMRLIIWLIFIFFLILCIGSLSYFQKQSRQLLGSNFTALVIDVMQAEEDAHL
LKRALMQLKSNSPYFDSNELKAISLRMQYRFPIIDRKMQKSSFEPATYQPYTKKLQMLKS
LLPELGKRIEAFQKDPSNKAPLVDLLTTFDVDMSFAYNELHTIIQVNSDIERRLKNKLTL
LIWGLVFAFLCTLFALCLAITHLYSKREELTIQSNVDHLTQLPNRRFIAEKTQEFLSEAP
DFIGLAILDLDHFKKVNDLFGHPAGDEALKAIANIIKQYTTPPHIAARLGGEEFCILFTD
ISERKANTICEDIRQAVEETNIPINNTSTQVTISVGLYCQANTCDAQAFRHIYQMADNAL
YLAKKQGRNQVVMFQKEVMDHA
>A0A6N3CUL0|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MFLKYKNHFFLLIIIIMISTVFIPTANFSDTIEAQNGTITYSDYSILKNNNVKLNGQWDL
YYNELLTPEDIKKRTPSNFYAIPGRLSNQIENVKSGYMTLHLRIQVPEDDIYGIYFYGLF
TSSEIWINNINYGGHGKIGKNFNDEKASYRPQYLFFPSENNQIDIVINTSVYREIEPFLR
SPILGVKDNITKLNFIKTSVDGFTIGIMLIMFIINAGFFFARTKQKRHLYFSIICLVLIL
RCLVFNSRLLVQFFPNIPFEVISKTAAITFYLWATFYVLFLNDIFNNRLYIKKPAILFGW
SFTILCLLTPNIIYDRIQTVPQIIVGIFIVYVLIFMIKELINKNKNIMLNFISFIVLCLT
ALNDILVNNSVIPNPYSALYGGILFVIVESFYIIIDYLQSIKKLEKLNTDGLTSLFNNKY
IKILLSNMIDRYIYWNEKFSVIMIDIDNFKSINDTYGHLYGDRVILDVATILIYISDNKG
YAGRFGGDEFILILPNTSEEEAIYIGKDIMKKIERLNTLNESERPISLSIGVYENTCDNI
HDCMNNADSAMYKSKTNGKNQINIISSSII
>A0A0J6ZBN8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MTPGALPIDGQPQLAADDQPPHFSEADYVRGMTRLTDVIQELSLSRTASEVQRIVASTAR
EVLGCDGATVVIRDRDMCFYADEDAVTPLWKGRRFPMEACVSGWVMVHKQPAVIPDIYAD
ERVPHDAYRPTFVKSLAMVPIRRRDPVGALGAYWAQRRRPTQHELALLQALADVTSVAME
NVQVHAVLEQQIGERPTSIDVAMPSAAAPGGLDATFAAAFANAPIGMAVIGLDGSFHKVN
REFCRIAGYQPEDLTRLTFQDITHPDDLDIDLAEASRLLAGEIASYQMDKRYYSRDGHVV
WVRLSVFLVHDDSGEPQAFISHIEDISARRRDEEQLRRQATLDTLTGVYNRNRFEEELRR
YKVRASRHSNVDEAAVFMIDLDGLKQVNDQHGHGAGDAYLRNVADIISRRLRLSDVLARI
GGDEFAVLLPRTTPAQAQQMAQTLVERVEALSPGTICIGIAMLTPDAIDEALERADRAMY
RAKRQGGSHWCGPEPAPVISEESTRSPGSPASSASGIR
>A0A379ZKB6|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MSLELLQAAALNLKKAVPLMLKHKIPTTPVNYALWYTYVGEQNPELNQRLDTVIAQYNTC
PPVSSELLYRQYVADPVELDVREMRQNLDAMVTELSQSLKDTNLDANEFQSRIESNFEKL
NRIEDEGFSVEQVLDLVRSLVKESDNIRSSTEFFTGQLQKAQTEIDALKKKLEQTEKDVL
YDALTGCFNRRAFDSDFAGMLAQAPLGTCVILADIDHFKVFNDTYGHQLGDQVLRAVAKR
LQESCRDGAKLYRFGGEEFVIIVPKSQLRIARQLAEAMRRGLEKLSLKDRRKDERINNIS
ASFGVAQWQEKQTGMQLIEAADKLLYDAKRLGRNRVLPISN
>A0A8B4FNT3|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDKVENDAWALS
DLARLYVVKPSPETLEQYQQLQRTDKNIELRLARLKDNGASREELALLHDGLQIAAELQD
EQQAALAHVAHGDAPAAIAVLYGNAYETELERMQTQIDRFRQMLENRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGGTTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGTAFRYGGEEFLVLLPGIDEAEAHQCASEIYTQVHAMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A8G2E8Y5|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MLTNFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITIALLILNALI
WPSVAYLASMVSKDMLSTEKKNMILDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALMWMMISFLTVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLSIVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSKLVIAMVHIIQKKIKDL
SLPSHNDIYCTVSIGISCAENKESIIEWIKEADEMLYEVKRNGKNGYCMPNN
>A0A3S4P962|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MHLPAFQTAHLRLAIILGVFGLVLNLFPIPLFANVQLILGNVAVVIVAILLGPWYALITA
LFTATGLMIVWSSPHVYLLFLLEALWLGFARRRDIQILYASVSYWVLLGIPLLAIYVAVI
AKMPASHIPFTAIKQAVNGMIYAAIGELCVVAIPSLWYFKGKLTNLNRRTFSSQLSYLFT
LIITVSLLVSSLAFNHFFIDKQQVLINRNLDDTATHLSHATDNYLAYNTQVIASTAKFLS
LSNADINEWQTLLSSIHDSNQGFKTMLIANEQGNLLAASPMASIVELDRLAEIPSVMDRE
YFIQAFYNHKTFVSPAFIGRGFGNDVIVAISAPIFSQIDPNQARGIVEGSLDLRYFSSID
KQNLHHEQQSILLTDENNNLIYASEGLGLAPLTPLSFSKGSEIYRARLQLMNLHNLDSNT
PEYIYAQHKLNNGWQLYVLEPFVPLLKLAERQYVNTVILLFCSLVGAFFITKAISKLLTE
PLSLLAQHFGPAKQEKASDEKFEHDLLDKSTPKEIYSLYESLASNQQALLEHQQELEQKV
QQRTQDLEAANVKLKDLAERDPLTNLYNRRYTEHQFPLIQQMCERGQDAMTLAILDLDHF
KQINDTYGHLGGDECLKVVAELLTSLFKRDIDLISRYGGEEFLLILPMCNALKVEAHLNE
FKRQLAGTVIINPQDHRSFKVTASIGAVIANATYSDSLEYWLKQADNNLYLAKEQGRDRV
VCSLIV
>A0A448ENK1|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MDFGLATELYPDEYRYQTEHYSPNDNPLDLVQVIQQLHASLDPRTVFACYGKVLGQHLPI
QGVRLSYGEHKLSWGKRYGISVKRQLICAGMPLTIQYQLLTPLTPSQTSNLKEIEPLLLQ
PLLNAMQYQEMSMQAMFDSLTGLGNRHYYSQSLSNATARAHRKQGSVALIVLDLDNFKQL
NDKFGHKCGDYILKEFGDIIRATIRNTDQAFRIGGDEFIIIVQGNIHAAGLLCERIVSAI
NQHSSFTQFGVSCSLGAAESHDTIEAEQLYELADKALYQAKAAGRNCYKLSQNQLV
>A0A2N9LRS9|diguanylate cyclase|EC 2.7.7.65|Acidobacteriia bacterium SbA2|TrEMBL
MGLIFVQLFPSSMYPYSAILLTLFLLLIYFRHQRIERANKNAELQWFSELHLFGRSLAES
AGPQQMADLTGQRIHDVVGSGGCYILVQASGSEAPGHVSAQGLSAESIGLLSADPLRSYL
ISCGERWGNLLIFPDLSRPSVDFAWQRDALFHELRALWVREGLRTLVVVGLQVRESSYGA
LLMGCRKPKNFRANELRLLLAIGNQLGVAMENWSLHRAAERHNQELRLLHRVSELLRTKF
DLESQVEILRQELQGVLGTTNFSLALQDSQDGPLKTVVAFQPANPDVLSGGSELDGLADF
VCQGRRPLLLTQDLPAKARRLGIKTVDGRLRTWCGVPVHFSDGAMGVLSVADFERDNAIN
QEQFELMQVLADEATGALESARLFQKERRRASHLALLNELTRKAASDLNPKELLSNICRE
IRSAFERDFARIEVADTQKKELIVEAEAGYGADLLGRRIQFGDGLSGAAAIGSEPILANS
VLRDLRYVALRPGVRSALSLPLKYRDDLLGVLSLESLREHSFSQQDVLTLQSLANQLAIN
LHNAHAYQIALDQAITDGLTHLKTHRFFREALDGEWRRSIRSGRPFSVIMMDLDCFKQVN
DNGGHLEGDRVLAAVAGVLDSRSRQSNVVARYGGDEFAILLPETTTEQAEILAERLRSAL
QADHYLHSHHVTASIGVASFPTHGPTPEDVLSVADSGMYLAKHCEGNCVRVASLRIAPGN
AERDQELLDACLGVAVKRMFANRNEAVNNRYLHRFEQMKPLWDTITALAFAVEAKDPYTK
HHSAEVSAWAAKIAVHVGLSRAEVEDIKLAGIVHDIGKIHVPEDVLSKPSFLTPTEFDLV
KSHAAWGAKILEPLKETGIERIVRYHHEAVDGNGYPDGLKGEQIPVGARIITVADAFQAM
VRDRRYRRRRTMDEAVTELRRCSGSQFDPLAVDALVQLIESDGGLPIPEPIEREHTLP
>A0A378RH56|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MNDQRASGPGNQPGGPLARWWRLPDQFEWLSGYLRARGLAWPTKVLMALISAGLILMGAA
TPTMRNVPTVWAWTFGGAAVLTGITYTTLWLRGWLSRRQSLRMACFGSSLIAVGCVMQTY
PMVALMGCTGMAVVGGYAAFFHNSKAITFIVVLGMAVGALCALRVVQNYGWAVAAAGWWL
VVELNLAVPLAIQAVMRTMGADVVRSHQDPLTGVLNRRAFYERAALLLTSPANELHLVAV
MIDLDEFKKLNDAYGHIAGDQALTAVGWALRENSNSSAIIGRFGGEEFIVVDAVPAELAE
ELPAQLCLAIAALPQPVTASVGAAIVRWESVTSMDDLIRAADAAMYAAKRAGGNQTRISR
PARVDR
>A0A1J5RWM5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MRIDTEPCIPDNSAVPDTTPTPSAAAAVALPVDAAGSGGGREATFRRIYPMRVLGMGLGG
LAIGGTLYAQHASALLWGWLALSCLLWPHLAFVHALNRRDPYAAERRNLLLDSAIAGAWV
PLMHFCLLPSAILVTVTTFDKLNTGMRRLWLQSIPMLFGAMIVVTAWWRPGVALDSSLIV
VVCSLPLLIVHTLATGMANYHLVRTTARQNRQLEAMRRIDPQTRLLSRESVLEHCQAAWQ
AHAATGAEAALLMIDIDHFKSINDTHGHGVGDEAIVAVADAIRACLRQQDVAGRYGGDEF
IVLCLGAGEVQAQYIAQRVLQRMHDVRELRPELRLTGSIGIAAAQPAHQSLRDWLHAADQ
ALYRAKAEGRNRAAVA
>A0A1Y2MYZ9|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia autotrophica|TrEMBL
MRAELGRHCAKGDFDHSARPVDGYDRELYRLDGGFGPGTTRGGGMTSPPAPLFRIDRWQV
WRVPSSLLGAMLAVELLAGALTLSDLVLRPDLDPATLGLLLTLTVAGLLHTEIVVGIERI
RRYTADTHHVNLTSVWTLAAALLLPPALGAVVVVVLYTHLYWRVLRPVPLPDRRPAYREV
YNASTVIVAVHGASAIVGATGPGGVYEGLPPILGLVLALLVYTVVNTCLVLGAVAIVNPE
SRILQILFGGDELVLELATLCLGALTAVALLTVGPLAAVLAVPPIIVLHRTIQVRHLREK
ADLDAKTGLLNHAAWSVRSAHALQVAERERRQAALLLLDLDHFKEINDTHGHLYGDQVLA
ATAQVLREELRDHDLVGRFGGEEFVVLLPRLSGHDGQDEVRQIAERLRTRVSGQQEGVGP
GTGASNSGPRPGRDGLGITVSIGGALFPADGTGTTALLEVADSALYAAKRAGRDAVRIGR
HQFPRPEIPEQTGEASEQTG
>A0A1J5TEF5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKFTRKARTRQLQYMGTAMAEKEVAHTVSVNKGDSHLHNQVGHRAFHDPLTGLPNRDLFV
ERMNRELARVRRYESGFALIMLDLDEFEAVNDANGHDAGDQVLCDVANHLASAIRDVDTV
ARTGCDEFAILLDGVMNKKEAEIVALKIMRAMSGPIKLGNGTQISVGASAGIVLSPQDGY
LAEQLMLCANQAMNVARNNGRGLIGFSRNLQMASRKVGQPSPGAPPTNMNLGISILDEQH
KAMANFIQGIIESLKNGDHSTKLLKRVDLLVELCRIHFKTEEDLMQLHDLDGSDAHRTEH
QVRLRQLRSIFGNLNFNEEELARVIHSANEWLWEHIREHDTQLASQLRNKGVS
>A0A5X9FMZ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tamberma|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1J5Q5Q3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTAPRELVVVGEFGPFDALADGAHAAYVGGRAEQAVHLCRVLVVLCRASGDRLTERYAWF
IAGLALCELGRYDEALGAAESLVALAPGRYLPFWKAKALALRANASAGRGDAARAIDDLA
HAQVLLGELDGRSYNQVSGATITGIGLRSMMLYEASDDLLSRAAAMVAGRGRANVLSESL
LTHAEWGSLLVLVGDDEGAAPHFVACLHRATQMRHALRGAADDPSLAAVAEWGRLFALEM
LGAHGAVATAFRLIVDDIPLGPHRSERILRSLACGRAHVALGDHRRARDFLMTAQEAAVQ
TNRVIWSSLADVALQELDVIEHGPHPALERASVRFQQLLRQRWTERSAWFDGLDARVRAL
RLATEAERATLLSRQDPLTGLYNRRALADRLAAARGEQSAVMVDIDHFKRVNDTHSHIVG
DRVLVAVGEILLRTVRIEDLPVRYGGDEFLVLLRPEVGVDPARAAEALAQRIQQEARAFD
WSTIAPGLRLSLSVGVASTRSPLEVISEADASLRLAKQAGRDQIIMRAHGVSDDQYTVSR
IRG
>A0A1J5RT67|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKPSSEQPLNTSADAPAARGFSLPVPGGSFATGWLAFVFAYGVALIVSESLRPPTALCSP
VWLPAGLLVAVLVSASERRRPLILGTAAVLGFLYALGKRDGVTPALLETFGGILEAVAAV
VLAGLWQGRRGSGSRGGAIGLLAISALPGPALGAALIASAHLLSPGSGGYLSTWLALWCR
DVLSILLIVPLAMGAVSERRSWMDLTFRVRRLEAALLAVLAAASAWIVFSLIRVAGTEVK
FLAVPIFVWAAMRFQARGVALAGALVSLIVFGLATWDPGAAGAFAPGLIELLQVFFVVAV
ATALMISIAWTEYQSSAGRLMRLRDAMAEIVVTLEVMRDASGAVEDFLVVDANPAFRTAS
GRQEPAASAVRLSAFIENPGLAYGREAEALLRDRRPRRLEVRSSRSGRWYQVSAYVPEDR
DRIVAVATDITPVKEREAEVLRLSRRYEIVSDVNQAIVRSASREDMLRQVCAALVREGRF
EVAWSGRFRGTEDRLVRVASAGDESLLADLRALGPEAEGMLARRAFEVGGVVACSRTGDD
PTVRPWGPVAARHGIVAVAAFPLREDGRVIGAVAVGTGDGQDFCREEIGLLEQVSQDVGY
ALDKIRSDELGAQTVANLLESDRRFRGLFEQAPIAYQALDVRGVIVDVNPAWLALFRATR
PESIGRPFMDFMPDEHRPDFIRGFSALVSGGGERAFEMALAREDGDPFSAHVTIRAQGDR
AGGFQVAHCVIHDISERLRYERSLREGEERIKTAFEIANDGIWEADLRTGKLTLSSRFYT
MLGYEPGAFDETPREWIDRIHPDDVARIVGRYPDFLASAEDSFEIEYRLRDRGGAWRWIM
ARGRVVEKGPAGEKARILGTNSDITARKQSELALRQSERRLALVIEGSALAAWDWDLHSN
EILFNAYWARLTGNGDAERILSAQEWRTLIHTQDLPAVRLAFEDHLAGVQPHFECEYRVR
KGDGNWVWVYDRGQVIARDGSGGPLRAAGTLRDITDRRLAEKQVREQAALLDQTQDIVIA
TDTAGRVRFANRSAEVFFGPSEEGLHDRRLADLFEGSEPVFDGAAIERVVADREWATEVR
LEKGFLKGRILDARWSVVHSDAESPERLLLVCTDITDRRLLEARFLRAQRMESIGSLASG
VAHDLNNIFLPISLAAHILKKSPPRTSAPRSMRCSTRARSGGPISSSSC
>A0A6N3HGU9|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MREDEVVKSPLRRAFFKTRFNPARIVNLCFIVVLICSTVLTWREVRVMEGAWVASQRNAL
NNVANVVDRQLQVSVDRLLFFRNGMQEALRTPLGLAVLHSVQGEFEDDRAQPYWRIIRDT
RRTLPLYGVSDALVSATPGLNRDIPLLHNELAAALELGYLFRLSESSAVVPRRAAYVSRA
GFYMSTVAAQSSEEIIHRYNRMLARPWFTSQSERQNRARGVRWFSESVNGDALVTASVPL
DYQRYWYGVLTMSFAVDTLYERLVETRQQDDSGEYQLYDAHFALLTRSTPPGVESQTFTP
EQKASLQRAIRNSAAGGLRMGTRYINWEKLRHFDGALVRIQTLREGIRGDFGSISIALGI
LWLLFTTMLLVSWAVIRRMVSNMLSLQKTLQWQAWFDPLTRLLNRGALFERASLLTAEYG
ARKEPFSVIQLDLDHFKSINDRFGHQAGDRVLGHAAGLISKSIRAQDVAGRVGGEEFCIL
LPGATLAEAEQVAEKMRQRIAGKEILVRKGKSLRISASLGVSCSDESGSYAFDYLQSVAD
GRLYTAKRRGRNQVCSDDTSSMPNS
>A0A6N2ZMJ3|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MLDINELFKEEYSVLEDARLAAADSQLPADACREKLWLVAKHYQRLIRESYRLISRSDRA
ERELNRMNEQLQKLAAQLEYEATHDPLTAVFNRSAIINLINRALTQANVALILLDIDHFK
RINDEYGHPTGDRVICALVSRIRKALPQSAAIGRVGGEEFTILLPEARLEDAMIIASYIH
SSLNASTLDALPGRSVTASFGVSLGRKNSDFETLYGAADAALYTAKKRGRNQVALHEDFF
CQPENTACKVALAR
>A0A6M5HYA8|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MDISAPNAFGTHKGVMLTHSLFVALATFLLALLSLSLSSEAHHFTPLWFPTAAAIAVLYR
HPPRHWGLPLLASGTGIVLASFLLFGLSAIPVKLAAINLLEAAVCALLLRRTLPAIDPLS
DLGCWLRFVVCAVIFTPLFSALLAAGLTPTPDQTFWQSFGTWFISEAIGVLSLAPLGLTY
HRRLLAGLNPYPLLLTLMGSLAFSYLALTHLPFPFTFVILPLLWAAIALSRFETFTVCFS
TLLLITVLLSLGLLRLTSSRHTFLGELGLYLPMLLILIPAHAMAMVMHTFRVEKQHIVES
ESRFRSALEYSAIGMALVSPEGKWLQVNQALCRLLGYPPERLYRLTFQEITHPDDLNADL
TQLHELLDGHISSYTMEKRYIRSDGQTVWALLAVSLVRDGEGRPLYFISQVEDISDLKRS
EAENNRLVERITLANQVGGVGIWEWVMSQENFTWDQRMFELYDLPPDQTPTLALWRTLLV
PEDRERTDRELAEILAQPRPFIMEFRITTRSGKLRHIRGQGNVILDDQGRPLRLIGTNID
MTELKSLAEALHEEKERLHITLDAIGEGVISTDSHQRITFMNPVAEQMCGWPLELAIGMP
VAGVVRLTNGKDGPEIENLTQYPRQWPADYALVLHSRDGRYFDVQQSVSPLKTLDGETMG
AVMVLQDVTASRELMKKLSYSASHDALTGLPNRTRFEKQLKAAIVAGGEPSSSHSLVFLD
LDRFKAVNDTAGHAAGDALLRDIAQLMRHQLRGSDCLARLGGDEFGLILYDCRLEQAKSL
MQQVVNQISQHPFYWEGKIYRVGASAGITRISADAKSSELLAQADIACYTAKHQGRGQVY
LYETRQKQLLERQHEVLSQQEVQTIISEGQLRLLTHAVAPPATPLSAAFHQVKLQVMAPD
ERPLSHEAFIAAAQLYGLMPDIDRWTAAQLLVKYADDIKRKGLSLALPLAIDSLLSADFQ
RYLTETVRASSLPPQALLFSVDEAAILEHAAQCRAFLRELQQQGCRLIVNGFGHNINAFD
ELSDQKIDIIRIDERFITNVHCNQMDELMVSMLNGAAHRIKAQTFAGPAHQPVTLQALRD
IGVDLADGDQVALEQPLAVLLSDGYFGIR
>A0A727M9P6|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F9I4C9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8F9I6M4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A6M3NQX3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A653NDR8|diguanylate cyclase|EC 2.7.7.65|Bacillus altitudinis|TrEMBL
MLRDLFINLTILVTFHYLLMLVFKENFLKKEDTLLRQIFKGMISGLLGVLLMFFSIKAGP
AIIDLRHIPLILTAFYGGIAQTFIAACVIIIGRLLIEANVASFINIFSMIFIATASFLIA
ERHINHVVKMLLSITMSNVIATILFIIIVNERSFELHTAYWMFSYIAGLFNFYVIEHQTK
AYQMLNLYKFQAHYDFLTGVLNKRKFDEILSDAFSLNLKQPIHQMSLIYLDIDYFKTIND
QYGHHEGDIVLKEIGTRLIKNTRSSDYIGRIGGEEFAVLLPNCSVEKTWQIAERLRKKMA
DQPIYLQNGTSIHITVSIGCAYDAGTSENMKQLPIIADQELYKAKQSGRNQVSFSGRKRE
HLT
>A0A1E3A7D8|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MQEQLGKRVRKRINILIGLMVVVAAAVFFVVGNQSGLENTAVDFGNTEDFSRGWYYEENG
QVKYVEELPFTAEADEMIFYHKLPDSGEEPVVLSFRNRQQKVTVRVGEKCVYQYGGSSPL
RGSLLPSIQCFVPLGIQDGTETAAIQIESTVGKKIMLSEIRLGSQGAVLMEFFRESWGII
LFGVLMVVFSMGLLAGGLVLRIRSGYTEYSMFLSAGMFVLLSSLWVLSDSPVMQLLTGSS
EVVFIVSFLCFMVFPIPMFFFVESICEKKYRGLSVLKLLFSFNFFIQVFLYMAAGVEFYK
MLPITHILIAASIIFTIYCLGKECRRNRSFYAREILIALFIFMATAFLSLADFYSNRKDY
SVIMRLGLLAYALILIVISFRKLILSGEERAKLKVYRSLAYVDIMTGCNNRAAFEKALEI
LRAGEEESELAGMAMIDLDGLKRVNDTYGHSMGDEMIIGAGDSIKKAFAGRGECFRIGGD
EFTVILKDKKLQEKEYRGLLEEMVSAYNDYHEIPIRLSCGFALIGTEKRDVDALYKEADR
NMYREKQKTKDKR
>A0A1E7WKT1|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MSSKPAVPEQNPAEIAREAFKRLALRRISPTPEAYREIYNEIAGISEPVAAPVVAIDPGP
EAVLNQFATRLTDGTGDLADFGRRFNRAVKSRDWDGYARMLSQLVEKHFISKKPGIEVAG
IGGVGGAAVVGSVEDEQSRVLRELLSRTLTFAVASLLAGAPALAAEAESLGSAAREAHNE
EALTEIGQRLKQLCFQIEVRGADSGEQQELLLRLFKLLLENVSELLDDDSWLQGQIEAVQ
HLISGPLDVRALEDATRTLKEVIYKQGQLKHSLSDVKLTVKNMMMTFIDRLGAVAASTGD
FHEKIGGYSDKISKADNIAELNTILDEVLKETRMVQAEALKARDKMVLARQEVQDAESRI
HALEAKLQHLSELVREDQLTGSLNRRGLDDVFDRETARADRRGTPLCIAVLDLDDFKKLN
DTYGHIAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILMPETTIDAAASTMTRLQREL
TKHFFLHDNEKVLITFSAGVALRRPNEEQTDLVKRADKAMYSAKQTGKNRVVMAE
>A0A6N3QN67|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGT
PLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEA
SENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIA
KRRGRNRVELWKASL
>A0A1E7WVT4|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MPIPESRNSKDSPFAWLSDRRQRSKEEIILMIMCALSIPSILPFGLYRLWQGAWLSAVVD
LALVLAMSLVIVHVWHTGRYKLASLGVTLFYSAGMLATIYLRGMPLVYWAYPTMIAAFFM
LRPRVALGINSVSLLVLVAMLLPQMELLNLLTVVVTISLVNLFAYIFSYRTGLQNRELHI
EAERDFLTGAGNRRAFDSKLISYAAERRPQPEACLLLLDLDHFKQVNDQHGHPAGDQVLR
RLCDVLRHHTRVTDEIFRYGGEEFAIIANGASLRAAGKLAETLRSAVATAPLLDGHPITA
SIGVAPMPRGGLASEWLEQADKMLYAAKEGGRNMVRLAGAMEERQ
>A0A2X1BSK8|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MEYILSEDFFNSLFIGKDFVFLVKKVGDDYQYIRLNQAAQDLLSNEAIGKMISTVTSKRN
FLIIQKNYNEAIREHKQVDYVDYAYVQSEVRKYETSVRPLKYKNEDYILAITKEILYDRS
IEDKFLFMRSMFDHAFFSTVILSAEGMIYEVNSSFMEDFQLDNETVKQKMFVDLPIIPKE
EVEQIKICLQKAARGENVGEKFIKLHTLDQQERMYLLSLSPVMQDDNSFAIFLIMQDFTQ
FTLQKAELRSKSHGLEVFKSALNSATAIAVLDHNCNITEVSEMFLQASGYTAEELIGQPY
ALIEPRFRGQDLFQIIEDKLDTMGMWRGELCYRTKYHADYWVETTIVPLKDEFGQIEQIL
TINYDITDKKRMFTELKNIERTFRLITENTNDLIVITNEDGIIIYASPSYGIYLGYENVE
LQGQFYSDIIDRESKGEWQTFLNNYTGQTDSQFELLLKAKDGTPIWTEGNVTVVHDPERE
KVSQIMMVSREITHRKERENDLLYLAYHDALTQLPNRRFLEKEFPKILAEANENQTCVAM
LYIDGDDFKEVNDRFGHETGDAFIQRFGSSLNKTVRSHDMVIRIGGDEFIVILTGLTRDQ
EKRHHQIMHIIRRIRDELAEGWMIEDHLFTPTASIGIAYYPEHARTLDELMDLADQALYK
SKESGKNNLSISDIH
>A0A6B2FQS5|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium 4M9|TrEMBL
MSADRNQQQTGRVKNPHRVVNICFLVVFVCSTLLTWREMVVLEHAYISSQRNTLDNIATS
LDRQLQHSIDNLLFFRNTMRYALQYPISTDKSRQAMAEFDALRREPHWQIRLDPGRSMPL
SGVSDDFVSANALLMRDETILHSELSAALEFSYILELSDTRRDLQRRTYYVSRAGYYISS
LPGKNDDSLIARYARQVSRPYFAQHDERDNHTRALRWEHSWDPTRKKDQVITASVPLDYQ
DRWYGVLAMDFTIPAMNKFLASAMPEDDESTILLYDRKFNVIASTKPQSDRPQFTQSQFA
EIARSMELSNEGELRMDGNFVTWDKLNTFDGVLIKVHTLDEGVRGEFGRISIVLLLLWLL
FTLMLLGSWIVIRRLVNDMMSLQSRLTWRANYDTLTRLFNRGAFFEHAQTFAKECRSRGQ
PFSVIQLDLDHFKSINDRFGHDAGDRVLSHAAGIISGSLRGEDIAGRVGGEEFCVVLPGA
TMAQAAEVAERIRERLSVKELLIRNGDTLHISASFGVSSSQESGDYDFEHLQNVADGRLY
KAKQGGRNQVCSEG
>A0A8B4S9V2|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MLRSMVLVAMIAVLLVGAGAAGWVAYSLRRAVMDGALPAQTKALEYAVRSLAFRVEQQQK
PLHSLSSVLAGHMHDSQESLQAMLKQPTSMAQQYEQLQLADGKGQLLVNLHQEQALAAEQ
LEEPLREVLKRSLAEGKPITQAWVRPGDAGLQLEFQNVVPVRDLQGKLQGVLGGSYRTPL
SVLFSLEVASAEAGSQLLLIDRDLRPLALSSKGQWQLPPALADAALPRGLDQAWLKTAQT
GAVSEQRNNQLWSAMPLPWAQWTLLKVSNVQEWVPGVSVKMMGWLATALLVLAGLLGAVL
CLIAYPLTALFRSAEQASRRGLMLEVDSASRRGNWWHGLSDHDWGEAQTLRTALQALGGG
YEAHGELERDLQMQLQTLMDYAPVGLIVTHGSTVQRVGMQAARVLGYQPQEMQGLAVRGL
CASDADYEDLMGRVRRALDTYGQFDSEVCLVRKDARPVWVRIHGQSMQRMHRAWEQSGKA
LDGQYLVWELEDVTTQRQLREQSSWKAMHDPLTRLPNRTAFALRLKEWLREYTTPDYLES
LGGANVTARSQSEPKAHGIVLYVDLDHFSQVNRQGGREVGDEVLGHIARLIESTVRPHGW
VARVGGDEFAILMAGISREEGMRHAQLLCMAIQDWEGSYQGQRYMLSASIGMLLLDASYH
TAASAFKGADMACYAAKRKGRNRVEVMTAAV
>A0A1Y5Q3D1|diguanylate cyclase|EC 2.7.7.65|uncultured Stenotrophomonas sp|TrEMBL
MKTGRPRWPRVLAACGLWLLLQTAQAAAAMHGLPLMRHFGVGDLPAAPFYSDIAVDAQGT
LYAGSSEGVMVFHSGLWELFELPHRAAAYTVLAASDGRVYVGGSGVLGELQREPDGDLHF
IDLLPEFTDDDGKPLPPADFYGLLETARGIVANDGRMLYRLRRDGGGTRQPLPEGAAQLL
FVAGGELYVRIAGTGVCRLDATGMVPLPGTAALDGLRLSGLWEWKGGLLYAASDGFHFGD
AGGVHKLPGDADAAFAAHVPYSSIRLPDGGFAFGSYDGTLMRFSPELQLLDSFMPARGNL
DGFGLDRDGGLWAVGESGLTRLRLPSPWTVYDQRHGLFNRLHDSAWYDGSLWVAALGLWR
AGPATGGVPRFLPQPWADTQLEVFALQGTGAGLVVGDRLGLMVLDPGAKSPRRLVGPQMG
SSTLRLLPSAFDPERMLALGSREVRWLAQRDGRWQLAARWPIHVGAINGIAQVAPGEFWV
GDERGGVHRWRFDARTGQLHDQQHFDVGQAPLADDGQGTHLVRIGEAVYAITGSDVRKLA
GEHFVPASLPVLPGLERPWELEAATTALGSFVWTTRQLWWRRPGESAFHLQQVSSSRVPG
FAGLALQGDGRLRLVARDSLLQFDPDIGKPSSAPLQARLDRIRLRQADRNDVLLPLQSAQ
VQVLPPGSGLALRFGLATMEPDVEFRYRMLGYNEAWSPWGANRDLGYRLLPPGDYRFELQ
ARIRGGRQAEPLLYRLRVEPFWYERGVVQALFWVAGLLLLVLAVRLRNRSVNARNRELER
RIAERTGELEAANRRLTELAVVDGLTGIANRHAMERALQRGWQRCGERGEPLAVVMADVD
HFKEFNDNHGHQAGDMQLCRVAAALAAEVSGVDELAVRYGGEEFVLILPGVGREAALQRA
ERVRQRAARAMAEAGMPGSISLGVAVRIPAAADVPGHLVHCADLALYRAKHAGRNRVECA
DEADFASAAQGAVIAAETVAPPPAPTLSSAP
>A0A6N2ZZA0|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MSIDRKTRAFVKELQRAYFEMRDTEKILSMATEDVLWSGLYHSNIHESGGLEAVLEADFS
RFPYPFTILDTSVETRVLSNTHCLADCQLRLRAGTPASTAPEVQLSGSLVCSLVDGVLRL
RQLHIARIDSSAHLPGLSQSILTASDPRIQRFIEKTTRELEARSQDLQQLTENIPGGIFR
CLYDEKLTILQVNDGFLSMFGYTRAEIRERFDDSFMAIIDPRDRSSTLLEVKRQLRQKST
KQIEYRATRSDGSTIWILDKGQLIKSESGPDSFYCILIDDTAGKEAQENLRLSLERHEII
MDQTTDIIFEWDIQKDTFIFSHNWQKKFGYEPMTENISTGTIAHSHILASDIPAFTGILE
DIRQGSPYVETEVRIKKANALYIWCRIRITAQYDENCEPFKAVGVIVDIDSEKRHSQELM
QKAERDTLTKLYNKGTTESIIEKHLSRCPENSLCALLIIDIDDFKNVNDTRGHLFGDAFL
MEIAGKIQTLFRSGDVVGRIGGDEFIAFIRDIPDIQVATQKAQQVIENFHSLDVFNEDDA
ETSCSIGIACYPDHARDFHELYKRADYALYQAKRQGKNQYVIFDRELEVMALKNAAMGVY
SAVNERIDSDSEVSPQAVNSQLVEYVFRILYKSIDIESAVHSILEIVGRQFDVSRVYIFE
NSEDDTHCANTFEWCNDGVAPEIQNLSHVSYATDLGGSYLDNFDENGIFYCRDIASLPKA
QFEVLAPQGIKSMLQCAIRDNGCFKGYVGFDECRNNRFWTQEQIAALSFISEILSTFLLK
KRAQDRVEQSAAAMKTVLDNQNSWIYVIEPGTCRLLYINQKTKDLVPSSEVGMYCYEAFF
DRTEPCARCPARSVGSASKNCTMEIYNPMLRVWSSADASLITWKNRPACLLSCHDITRYK
ENQT
>A0A8B4S8W5|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MTPSSQPIRASKSLKLSLILPFVALIALLTSALGMLWYWTGSNTVSALSEQVMQEKAERI
ALIVDRHLYPSSAVLEAAFPSGQPVAADISDHIPDLISRLWVATSLHTRPNDYVYYANIA
GQGIALKRVAPELGQLRLKTQPGEHRSYFKIAGMPAEPIYESTETNLFEPRQRPWFKLAA
ESADVIWTPAYIDFSAKDLVLTRARRILSSKSSLEGVVATDISLRALNEFVNQLHLSEHG
RAFIIEADGSLIAATGMPNIHQREDGKLERMTAANSQDPLIQAVYEKIQGAFQSSLSSDG
PGTALLEDDRHNHIRIAYRRLSNGAGQDWMAVVAVPHKDMLAGVYRHMALVGSLGLLALV
VAVVIGTRIFGAVANDMRSLTRAVRRVGQGEIDTPIEVQRRDEIGELAHNFHRMRHSLFT
DPLTGASNRSALQHILTTLTRPLPGQNMAAPFALLFVDLDRFKPLNDRWGHDNGDLALAE
ISLRLRNLLRPDDVVARLGGDEFILILRGVSDEEQVQAVRLKIEHALQQPLSTLQGIPEG
EAVTVGASVGQALYPRDAQDAQSLLKVADQDMYRNKRPAVS
>A0A6N3E1Y0|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MNKNNQKSKDGNWQISFSPIFRYVAVFCLLIFATIMLGGAVLSFSQMKSNAQVLLSNVHA
QTSQRIDESITLLESLASLPEFYDPNVPPIEKVKKLDQMSPYFDYLMICYVDSNITVYSD
GSEPASLASRDYMQRLFSTGQRQVTDSFAAGADGVTLNYTVAVPLLDAQNNITGCLFCAI
YFDEVVDILKQSAATSGYEATLIGSQGQIMSSTAGLPYGEPLMKELQNARVIGTTPDKLQ
EQLLAAEPGDYWSLQNGSLVYTAYQRVEDTGWDLLCSVDFRTAFLGILPSLLLVAALAAL
LCLGLSFLLRRYIAGQMHSVDLLVESVEKLEKKLYQDERPENVDFNEIIRLTSDGLSDAL
TGLVTRSVFLNQAEAQLQKINPEYTSALCFVDMDNLKSINDTYGHYGGDVALKNVGYILR
EYEKKYDGLVSRYGGDEFVMLLINLDDEAELRSVLEELVLRLHSEIGSAGQQINVQCSVG
VSLCRPGMKLEKMIADADEALYFVKQNGKGYYKIHQN
>A0A2H6AZE5|diguanylate cyclase|EC 2.7.7.65|bacterium HR40|TrEMBL
MNDETRIVQIGERAFAALRERGILPSPENYLVWYTHLAGENPALSRMIRLLEQNRDSFDA
KRCRELYARYFLRSDMQRTLAEATDRIKGLTERLGDLLAHSGEESARASSRFEAAARALA
TTCGLEEIRRVVVALDAEARRMAAETRTLGCELQRSSREVAELQSHLERMQREVETDPLT
GVGNRRHFDVALKRLAARSLEDGTPLSMMLADIDHFKRFNDTFGHDVGDVVLRLVAGVIR
RGVRDNDVVARFGGEEFAVLMPGVELAEAAAVAERLRATVAGRRLRSREDGRDLGMVTLS
IGLSAYCPGEPLDRFFRRVDSALYEAKQGGRNRVVVRDVEDRLVNEEELARAGRAGEQAR
ASA
>A0A2H6B384|diguanylate cyclase|EC 2.7.7.65|bacterium HR40|TrEMBL
MGECRGPHGKARAIAVQVVKSLRRHGLPPTPEYYELFFLYHEGSHPALARDIESRLAAGE
SLDEATCRTLYERHVARAGLEQAIERAGEQLAELGSRLDDEVAEAEVGFRQSAERIERLV
ARAADSEEPRELKDLLARALAETRAVVEAALQLEHRLHVTRAELSAVTEAFISARREAET
DPLTGLPNRRRFERAVAHAVERVRRGGPAPILLLADIDHFKDFNDRHGHVTGDLVLKAVA
QLLRRNVDERDLVSRWGGEEFAILLQPRGLAQGEAVAERLRRTVGSRRIRQRTTGRDLGT
VTLSIGVGEASPYDTPEEWIERVDRALYRAKRRGRDRVEVAEPPARSVSPAEIAFTPGDD
DAPAAATVAPRLPAAEERP
>A0A2T7YVZ8|diguanylate cyclase|EC 2.7.7.65|Bacillus thuringiensis|TrEMBL
MFIANSFEEGELLFQRTKPHIIITYVTDYSQIKYIKNMYTPHSTFIVIWDQQITKEFTDV
LALGIRNIVIAPVTPQAVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFQNDLLFIVEDDE
IVDCNTNFLAFFGYENLFAYREQHLVFAEHFIRENGYYSTTHDITWLDDTLSSGRRIKML
NYEGAVSTFLLRATPLPEDLSRFIVKCTEITELDETYQEQERLAMIDSLTEIYNRLKFQQ
ILEVEWEKVIRSDEKIAIILFDIDNFKTVNDTYGHDFGDLALIQLAELMKSKVEQQHVFA
RWGGEEFIILVTNTVEKEAFQVAESLRFFIETKQFTGISKLTASFGVALYEQGTTREELM
QRADIALYEAKKNGKNQVCVYRKEKM
>A0A1C5LNB9|diguanylate cyclase|EC 2.7.7.65|uncultured Faecalibacterium sp|TrEMBL
MNGYFYVLTAIDLFVLSFMCILTKLSESLNKKQKQGFFFAFVLIAVISVLEVVTLAVDGT
PAGYRWLNILSNYLGFGLSPGVCLCLVYVMDRKKRMNRWFRAAVCCEACYLLFLALSIPA
GLVFSVSADNVYSRGQYFYIYIIMYFAAIVYLSVSTFVTAREFQNRSRALIYPLTFFLLI
ETIIQVTLPELHVTWLCVTLLSVLYFIYCSEMWNQLDALTGLLNQNSYLNRTAEMRRRGG
VLVVFDVDDFKQINDRYGHLQGDICLAEIGRCIKKAYARSGYCYRTGGDEFCVLMENANR
EAQCAQEFVRQLEQRRKAVDFLPTVSFGSAPFLGRTCWL
>A0A4Q9VSH1|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum|TrEMBL
MPSTSPEQQAVEWKLMLMQFPAAVAAQVRELAATHQAELAGYFYEQMLQDEQAMLFLTHE
QVKSRLHGTLQQWIVSLFSSTGDETALLALIAQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFELLCRQPLDTEHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQH
IGVEQERQRSALLDWENQLMFDLAVGQFAAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQSMQQIDEVLLPLFEKAVAEPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDHFKQINDEFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDVHQGQALGVAEKLRQQAEKERFRLSGEHDLQLT
VSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVVLARELPG
>A0A857JI63|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MKYQKRSSEEQIVMSISAAGALCILPFLIIRIYNQDWHIALLNFSTIAITSGLFAYVYLT
KRTLLARWLLSITCMFIASGTIWLKGPDQIVWTYPAIICLFFILPPNIAALLSAFTVTLI
GCLLFSDISLLDNVRFYFSSLITFIFSYAFADRMLYQQAQLMILSYKDPLTGVGNRRAME
EQLISTVQLQRQRPSHRKASLLLIDLDEFKKINTQQGHACGDNILAQTAALIEHLLSSDQ
HLFRFGGEEFVVLANNDLEQTINLAENIRETINDFQFEKGIHLTVSIGLAEYQFDETSFE
WLGRADTAMHQAKAAGRDLCCLAAS
>I3TUJ0|diguanylate cyclase|EC 2.7.7.65|Tistrella mobilis (strain KA081020-065)|TrEMBL
MPTTAGKTAARHDIAADPNPSLMAARRDWHRLQAALAPEMRDWLAGLVSASSDELARDFY
DVLMADAEAAPLLSNEIVQTRLRGSLAGWIRSLFPAGPAPDFDSMATVQTRVGEVHARVR
VPLHLVSRGARLIKAGIAGRIAGSRVGRDELVRLLLHVETVIDIAIELMGAVFVSGITHQ
SRDEEAYRLFFLSQDLSLERESQRASLLEWNQAVLLALAGGSGSTEPLPRIGRSDFGLWF
HHRGGIMFEGTPVLDRVNELMQRLDEGILPETDAARAAGDGFGPALGLIQAAVNEIRFIL
NDAFQAMIGAEAGRDALTRTLNRRFLPAILKREITLAMRRDHPFAVIMVDLDHFKTINDS
HGHSAGDAALRQAAETILGTCRSSDLVFRYGGEEFLVVAVEAGEAAARALAERLREAIGK
TEVVLSGDTRIRLGASVGVAVFDGHPDYNHLVEAADSAMYQAKRAGRNRVVVAGGR
>A0A0A6ZT98|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MQHYFYYIHSKHITSCFIFVDDVLSCLQRLNNQHLPAVSWSCSVSDQIIARVSQSLAKEQ
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
KRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHPALHS
>A0A0A6ZRY3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAS
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCEVYWQ
>E2XIZ9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LAFLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNT
>A0A8B3W7Q3|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MNKNNVLGSFLLVVTMSAVLGLYLLYPLNDVDLSPPQADNTSVYTPEKELSQTEYGKKLI
HILGLSRSDPSVAKHQLVLLRPPTGVNDKAIYQAYRLMILSNVAQHQRDADAVMAYVEQI
KALSEHEGMLWLKSESLVESAIEYLKKGELAIAEIEIRSAIGIAESIRYDKLLVKAYNTA
GAINNVRNDLQDAQYFFYKGLQLGKQYPTHIYNSKLMSNMALLYIYLEDWPKALRIIEKA
KKLYFKSGLLEDDAIGILYINESFLHLSSGDVTNGRIAYEKAKALDSKRVSARYKILLLR
TYSDVLLSEGNFSKALQVANQCLQAPNIKKYTLQNGQCYLNRALANIGLDQDDAILNDLE
RALAIFEVVGSRSWKVLGLKTLAEYYESQGDLDTALSYYKQYYHGNKALLFDKRQSDIFL
LEQDYAKQTLANENELLNTEKDLNELLLQKEQLRNRIVVALIIMVSISAVLLAIRLRSIQ
SKNKALVTQSTTCALTGLYNRRYLEQLLTQPMPFNTSRFGISLVILDLDHFKRVNDTFGH
DIGDEVLVEVARRVKQHLFPNDVVARWGGEEFVMLLSGSIDPEQQLNVIRLAISETPIDT
HSGSLNLTTSIGASIGIAHEQLNQDTYKKYLKAADDALYQAKESGRNQVIIAES
>A0A8B3W4T6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MSDKAFRKLNIFLSIFCLAITLVSLISFNTLMNKSYVITLDKYPTRVNTDRDRDHDGGTV
GSLHRSKDGIELQCDFERTYSLPFCEIEFVISTQGKGLDLSTFDSVTINMDYQGQEDPRF
RFYIRNYDKNYSVKGDAMSNKFNRLDFSLPDKNHIDLNYFNVPFWWIDHYNQPITSSAVD
ITNAVSVELGLGASTLDGHHSLKISSIVFHGKIISKALLGELLIGLWVTYAICYVGCALH
IAQRSKTRAAEQQRYLTQEIEELKVKATTNPLTGCRNRTEALDTFYDFEWLAQQGKTIHI
ALFDLDHFKQINDQHGHEVGDKVLIQFVATANESLGEQYLLYRWGGEEFLLVCLEQTALQ
CNESIDNFYLAMDQRPWPKALKVTTSTGVTQLKEHESIRTAIKRADKALYQAKDNGRNQV
VTFD
>A0A7U9IYV9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli HVH 36|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHTWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>F5NTP3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSA
LEAMASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDSATIIRHADTAMYTAKEGGR
GQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIENHLAWRSAQSGSTSTLAVT
>A0A5P9C1D9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSEDAQRWKDKYLSSLERHEKLERRWELRLDLLRRGLVRSSLAAEGADKAVDQCMQEMRD
ILRRDDMDAALGGLIPRLEKAVLESEQRRQKRAAEAATALARLVTQLQDLEPPREVRKAL
KALGKQLDEAASHQYLLPALLSQLSNLQAQALAVQQAPAQDQPGLLQRLFGSRSESASDA
PVTPAPAPAADVPPAAEPAAPSLPVDEPLPAAPAPASIPAPAPAPAPAPAPAPAPAPAPA
PVAEAAAGAAPVRQEAAEVPAVLDSLPVPPGLVPLDDEGDGPFSLPSSEPGYSAVAPHIA
NSLRNLLDELDLPASHLPQGEALRERLEGNLNWYELVPVLDDLAVLLLAVNNGGQREFAG
YLKQLNERLAAFIQTLSEAHEGYGASAQSARNFNQQLQDQVTDLQNSVQEAVDLDALKQA
LEQRLEGLLQSVSNHQRQRDSAEDDVAERLQGLVKRVAEMESEAQQFRAHIEEQRQKSLL
DPLTGLPNRAAWSERLELEVARRQRYGGQLLMAVLDIDHFKRINDGYGHLAGDRVLKIIA
GELNRRLRKTDFMARFGGEEFVLLVPATPLEGGLQLLETLRSAVEACPFHFKGEPVTITL
SAGIAEFRDGESAETAFERADQALYRAKGAGRNRVEQAA
>A0A4P8C0A9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:NM|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKLTGRNRCMFIDEQNVINRV
>A0A8I1K3Q7|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MIFDKLLPSQLNMKNPQKVVNLSFMLMVLIFIVLSWREAIIINESYTESQRNKLLSVATT
LDNRIQYSLDQLNFYQSIMVQALETPLVTDKTRAVQQRFDQIRQRTVWQVEVDLARGMPI
NGVSDAFRGQFPLLHRLPVGALHKELAAALEFSFILHLRDELKELQKRTYYISRSGFYVS
SAPPQNHKEQIVSWRRMMTHNYFTNGQPSRNPQRKLTWTEVYNGILNEGPTITASVPIDL
HAEWFGVIAMDFSTRDIHQYLSNSLPSQNDGTLLILDKKFNVIASTQPTAAAAALTPTER
RRLASALANDDFGTLRMGTRFITYSALKNLDGTLVNVHSLSEGMRGEYGRIISVLLIMWL
VFSCALLLAYQVILRLVRRMSDLQGNLAIRASYDTLTRLYNRGAFFEKAYAIVEKCRAIN
RPYSVIQIDLDHFKFVNDCYGHLTGDRTLATTARLVLGAVRQHDVVGRVGGEEFCVILPG
TTKSVASQIAERIRASLEGAMILTDDNLPIGVTASLGVACADEDGSTALNDLRMIADRRL
YTAKKNGRNQVISDDTPSTGA
>A0A174LV04|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MTEYLKKWRDKGTGKTRAILCILVYILIMVGMIGSLRMQSKGMADRMAWAVFIVSLAAMG
VISYPLIWGKDRGEGERLEEGKMEKQNEQKEQNKQNEQDKQNKQDNQNEQKEDRREALYR
RLGKFTDTVLFEYRYRDGSILFTPNASNQMETSVLKSALEKYVKCPPLQGESRCFEFRMK
ADTEDYRWCICHIRAEYDGGKESGDKYAETERPVCLIGKLDDISKQKEREEQLLFQSTRD
GLTGIYNKTAFEYMMEETLKRGSRGSLYMIDIDNFKDVNDQYGHPAGDKILVKTGELLRE
IFRDSDLIGRVGGDEFVVYSESGDTKMKALRLLNGTADFTKEGELRISVSIGIASSTGDP
GEEYQELFSRADQAMYRAKQEGKNRIAWYEE
>A0A1X1EN42|diguanylate cyclase|EC 2.7.7.65|Pantoea cypripedii|TrEMBL
MQEEIEQYIAVILQEWRPLRAALPQDVIAILRQIADTQSDNLAHRFYETLLKDPAISRHL
SYELVEERLSSSLSKWVKAILTEDESQFENLAQLQYHVGGVHARIGIPVEFVQRGARQLK
YGIFAYVAQHDIPYPLSLQVMHYAAMAIDIAIEMMSHAYAMSHYRATRNEEAYRMHVLMN
NAWQEQGKQQSALSSWENSVIYNLVSGVPQTEQLLNISESNFGLWFRHKCVRQFGENPQI
QQMRQLMAKIDTTMAGIDLTMAIPVEKLQELLRVIHANCQKINTYMEMLFNDVSHMQDGK
DALTNLLNKRYLPIILKHEVSLAMENRLPLSVAIIDVDFFKKVNDEWGHSVGDRALTHIA
NLLSDNIRASDYLFRYGGEEFLIVLVEAGQSETYTLLERIRRIVNNTPFETVSGKTITLT
VSIGYTLHSGHPDYNLLLNKADAALYEAKRGGRNRIVQQ
>A0A161GCR8|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MLAVFAAVTTVLYIANGIASWSDLSGPQQLFAALAVVLGPAAIVVLARAGAPSPKHAVGT
ATALSVGALACALGSSNTMPAFLICVQAAMFLGMHIGAFWSERDAGIWVAVLAVSAVVGA
AVAPYGTPFISYILVALGIVGATEVFGVFARRMRYSATHDALTGLLNRFGFESKIEKMLP
ACAARGLTVSLAVLDLDNFKEINDEYGHIAGDVLLTRVSKAWKGQLTKRDVLGRLGGDEF
VLFMPGVLEAEAWQVIDGLRRSHRAEWSVGLACMPAGRRWGEIYRAADADLYRAKRSRPP
KASRPTEPGDGHRGPVRRIV
>A0A202FCT7|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MNILKEIINNYFNLTSTIITLVTIGLITIITIISYGLERRITDKSPIYIRLPIHLTEGAI
LAGSMIILQQTFHVLNNSSVNNGWLYANAQLTILLYSMYLLRNKITLLINLLMPFAYHQS
NNLQRLTNVKLPYFIVSYIFLVAIVIYIYWQTDRLQDSTIKYLALQILYGIAWWILLWVD
HSFSFSNIFYMLIVFVIYMAIIRFCEHKMQLTLAGYDTLKKAVNYDELTGIRNRSNLDKS
SKEIYDKYSHENRVPLTMAMFDIDHFKLFNDKYGHATGDEVLRHVAHTMERELYLRKTHG
EIFRFGGEEFIIIFRDKTAEECSPIIVDLRNALYSAPLFLNGKKLNVSVSFGVSELKSSD
TGFTDLFNRVDNYLYKSKNAGRNKMTVEDVIYDFDENK
>A0A5F0JT35|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. A11|TrEMBL
MDKDFTSTPRPTFKRTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLATLGKQGQFAVAEVVNVHKKRFAYWSWNPEDNTDTLGALVS
RWLFPEPVSQPIMHNGSMIGEIRLTARDSLISHFIWMSFAVLTGCILFATVVALTITRSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDISAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRYQSYRLGGDEFAMVLYGVHSELEVQHISAALSQQFIRPFDL
HNGHTASMSLSIGYALAWENTSVEALLEHADRNMYLVKNQRSKTIS
>A0A6N6JXA3|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MNKGPSPIKRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RTLEAALVFSDSVAASETLAALGQQGQFSVAEVRNQKQKVIATWRYDAQDTTDKISGIIS
HWLFPQPVTQPILHNGDVIGEVRLIARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICTALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKNLRAERIIKK
>A0A7X5FY53|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYEDLPLLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQALSNQQQPGETERMSLLQDIRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRRPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELRIAASMTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETYRE
>A0A649YX50|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MKYRFGNRWSVFLLAFTLFSLAVGLIESIDRSQKNFLRDSLLDRAKEELSIVRSELESAI
VYDIFAVNDISALVASNPSFEYSGWDLLASSIMRKASHVTIIGLAPDDVIKYIYPLEGNE
KALGLDYRTVPSQWRTIKKAREVQEIFIAGPVNLVQGGRALVARIPIFTDPLYNRDYWGV
CSVVISLETLFIDAGAEEFSFKYNLAMRGINSSGLDGEVFYGSQSTFDNAFATETVHFPY
GSWIIAASTKDDLLRHSEWYRVHAVRLLGYPMVLVLLIAFVTIFRLYQAADRRSLHDELT
SLPNRRYFMYTLQGHFDAVSHSGKGEVFAILNVDLDKFKQINDTYGHAAGDKVLIAVAER
IKSVLRASDVVARIGGDEFLIMLPRISSIEDVDVLNIELQKAICHTPVIFEQHLINIHVS
VGFALYSADFKDVDDMLKLADVRMYEEKRRQAQRSGL
>A0A399DXJ6|diguanylate cyclase|EC 2.7.7.65|Meiothermus taiwanensis|TrEMBL
MHFWDTSFHVNATFVKVIGVHPEVGLLLLAVASGLALWWPARTEPVWRWASLGTLLWGMQ
AAVWLLERQGGLEASLTPSGVLLFAAALTWAATLRQLRLYEPPRLSLALLPFVLAALVTA
LSGLPDRSSQMVWLTDLLPVLLALPLLEAALHGQAGESRLVWGLGLIFKAGGSWALALGW
PPSGFVYLVWALGFVLIGWGGYLEATETRLGKGLLGFVLGSLLGSLVLLGWPSQVVHPLH
SAVLVGWGYVALVALGGVGWGVYQRIIKAERQLELWINLLESLSTKTQSTQNLTPQGVLH
SVMDGLRPLYGNLAGIEVRSDVTIRAGQSGPYVYTFELALDTPTEGRLYFSSAPKDTRRL
EALAPLLTERLRLSLTLNEWRSKAYTDPLTGLLNRRGFERQLQRLIRLAGERNKPITLAL
LDLDRFKQVNDTYGHPVGDKLLKQLAEVLHKASRSDDLAVRLGGEEFALVLFGADLEDAY
RVLERIQSEVRALQISPIAWRLSISAGLAGGEIPPSMATVQRWLEQADRALYKAKQAGRD
RIHPALISSRLAED
>A0A517ZCR6|diguanylate cyclase|EC 2.7.7.65|Maioricimonas rarisocia|TrEMBL
MQAKLAQVSRLPSLPTVAVQVVQAFSDPDVGVQEIAQILRSDPAITGKILQAANSSRFAT
GRQISDIHRALMILGKKVVSSLALSFSLAEASMNNGPHVEYFKSFWLQSFVQGLTCELLA
ESEPSISNGEAFTVGLLASVGRLAMLKGMTEEYIPCIDAAHELGLPIHEVETERLPYTST
DVSATLLSQWKLPEYCTTAVQLQHTPASAMSEVFAEQDSRMPHIVAVAVAVGEYFAGGQR
GLALARLYEMMEQLLERPASGVDALLEEVRERLEENASLFEIDLAQLGTPMELLADAMQQ
LSFLAATSIIEEHPQQRAPSELLEENGRLRKRVAELTRQSSIDPLTSVFNRAYFSRRIGE
EIAVASIQSESIGLLVADVDRFKQVNDTYGHLMGDAVLREVAQALQNSIRGNDFVARFGG
EEFVILVRSTGLEGMAALGERLRESVARTKVQFDGQTVSVTISIGGALGHPADRPQRFED
NLFASADAALYAAKNAGRNRVIIGPFELSGDNNGEATSPELRRRRGDAPSSTTPAVEV
>A0A6M8MHR7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MMSQRVTAQTIQRLLLKRFALATGTYVLGLMLVWMAYFTGYYHATFFGIWCTSVLVLFCQ
AALSLVFFGGYNRRFKDPSLTEFQVLLGLAWQTFLISHMEASRGTFLVIYVLVLMFGLFH
LRPSIFARCALFALLGFAGVNLWDASRGRLSDPGLAAIQTCALFIVFSWLCLFARFVQNS
RNRMHQRRITLQAHQETLRGMMLQLEELASTDELTNLCNRRHFLRIATRELELMDGNYTA
GLALIDLDHFKRVNDIHGHATGDRVLQMFGKTAAECLRSDDILARYGGEEFVLLIPRCTR
AQLVECCERIRLAFTHVTLPELPELDLSLSIGMTVIERGDHMDRALQRADQSLYRAKHQG
RNRCHGAWDYADA
>A0A6M8MCT5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MNSLTADDRTQVTREATAEYWKHIIPIVQIAFAIHVLLLGLFLIVDLPVMWVTNAASVMA
YIACLMAIKRRLYRCAGMLICIEIIAHAAIATWRLGWDSNFHLYVFCIVPIIAFGFHSSP
VRRGCLSAAVLIVTVGGYLMRNKVPVVSISENVQDLFGAANALTATALLLHATALSVRFN
LSMHMNLYHSAHRDSLTNLYTRRRVLQRLRQLGGGRREIPTALVLIDIDHFKQINDQHGH
DMGDVVLQQVADVIARCVRTADIAARWGGEEFLVLMPNTTFEEARLIAERILMRISEQAG
EIRQVSLTLTATLAVAILKDGEAFRDALNRADQRLYEGKQEGRNRVMLAE
>A0A7S6YW32|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MSPGTLHRNSESAVLPQRVLLVENSRTFTSMLREAIEQRVELPVTVVSTLAEAARVLDEE
DGWFLVLTGLVLVDGDRDKVVEFFLSRKLPTVVVSGVYDEDLRQRVLQQQIIDYVLKNAP
GSIEYLAWLVQRLERNRRIAALVVDDSLSARTYAGALLSMYGYRVVLAADGAAGLDAIER
DPDIRLTIVDQEMPGMDGVEFTRRLRAIRSRDKVAVIGISGNSDSSLIPRFLKNGANDFL
RKPFSREEFFCRVSQNVDQLELIGTLQDLATRDFLTGLPNRRYFLEQSQRVIPKLLLEDQ
TVTAAMVDIDHFKHINDTWGHEAGDQALRAVAASVSGHARPQDLVARFGGEEFCLLVPGL
DAANATSYFETLRERISALRVRVGDETLSMTVSIGVCIASESDQSLHYLLNEADKHLYLA
KAGGRNQVRLAS
>A0A0S4UXY9|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum|TrEMBL
MQPLPNAVGLPLPQATPARHAAAKAQFFRQVFPRDTGMQNKQDAVERRPIIHARTTAFGR
RLHNRQQRLQCLPQFIADLLSCHANNNAQPPAFDDLVLLAALNGTRRERMSEPAQRQETS
PLRTDDVTGMDPCGAPSRMEPAPVVLIVDDEPSILSALTRLLRKPRYTVLTAEGGEAGLN
VLASTPVDLIISDMRMPYMSGADFLARVQARYPDTIRILLTGYSEVESVVRAINEAGIYR
YLNKPWDDHDLLTTVAQALEQKRLSREAVQLTALARKQNDELRAFNAGLEAMVLARTEEV
QRLARHDPLTGLYNRRVLAAELEAAIAESRVTGCPYLVLIIDLDRFKPVNDLRGHRVGDI
VLCEIAERLKDALRRSDTVSRLGGDEFAVIAKADRGSYAESAINLAGRLLAEIRKPVMID
GNRIEIGASIGIASCPSDGSDAECLLRSADIAMYRAKREARGSFRFFEQRMDEELREQRE
LEVDVRAAINNGLVLPHYQPLIDIRNNHLYGFEILARWQDPVRGAVPPDIFIPVAEQLGL
IPRLTSSLLRHACRDAVRWSNDKIRLSINISPSQLKDIRLPDQLLAILDAESFPPPRLEI
EITETALVGDIETAKAVLSALRAAGITVALDDFGTGYSSLYHLRELKFDKVKIDKSFVQS
MQSNNESDKIVEVNRPGFX
>A0A1M7YVE7|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MYQKYLFRWIQTIIQNALIFIILFWGISQAGSAVESSGEIRFSQLSAADGLPSNVIYDGL
QDSRGFIWISGSAGLIRYSPHEVRVFSRDIEDKTSLISNSINVLFEDTQGHLWIGTKAGL
ARFDRHSETFERFIHEPGQPGSLSDNHIRSIFEDHAGVLWIGSEGGLDRLIPGENRTWTV
QRTRILSGLKNININAIAQDKTQHLWLGTDNGLYRWNPKIKKLRHFIHHSEQSDSLSDNH
IQVLAYTSSGRLWIGTLNGGLNLYVEADESFTHLRHDENDPLSLSSNDVQDILWDEQGRL
WVATTGGIDLVQGQKVTRHLLRQTGVSHSDDVAFITSVWADRHERIWFGTLGAGIYIQDP
NLKRFKNYLYRHDGHGISARHIRGMAEDARGNIWFGTHSDGLFQFDPVAEKVTVYKSVAG
DHNSLSSNRVAAVIEGDDGMIWIGTGGGGLNKFDPETKRFTRYVYAADESQNPAAADSLP
HNFIPWLIKDKGGILWLAHFGGGLTRFDPKTETFTNYRHDPDDSHSIGFDILTSVTPLHN
GQVWIGTYGKGISVFDRQTKQFRHYRHDPEDPGSLSDDTVRHIYEDSRGRIWVTTNFGLN
RYYPDKDKFRVYTTKNGFPANNLLAVVEDNSGQLWISSSKSLTRFNPDTEAIRVYYREDG
LGVNSFFFYAFGRTRAGQLMFGGDNGFSLFDPMRIEDNLHPPEVVLTRLEIFNQPAEIGP
DRLLKQSITETRSLSLPYNQNSIGIYFSGLNYTAPDKNTYLHKLEGVDKDWVKTGSDRPF
ALYNHLSPGQYTFKVRAANNDGIRSNKEVSLALNILPPWWQTWWFGVLLVVLSGFLLRAI
ILWRVRLIAEQNRYLESQVQIRTEELEMSEARFRGLSEATFEGIFIHEQLKILEVNQYGC
DLFGYDREELLGRSGRILLADETFETVRDNVRRGNECSYEAIGKRRDGSKFPIEIHAKQI
PFRNDFVRVAAVRDITERKQVEAELIRLTLTDQLTGISNRKYLDTMLANEMERAKRHHIP
FVIIFVDIDSFKLVNDIHGHLVGDAVLQGVSARLKQRLRVTDILGRWGGEEFMIICPDTE
SEAGRELAEGLRNIIGQSDYPGAGRVTASFGVTQYRPDESDDTLIQRADEALYHSKRQGR
NCVTLR
>A0A5C6D9V8|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MTEILAPTVAFAPTAVVGPSASSLEDSQGNENQISRLLEGLREAAPAAEENPNAKSVDLK
FENRLAMVRLGIATSLFYSLRAKHVATAAHSLRVALSCSTWAHRLGLQESQRDRIEVAAL
LHDLGKIGIPDRILRKPGKLTVEEQLTMDCCSRLGCEILRGCTDDAELLDIVLHANTWFD
SRRYEDGPRHDALPLGSRMLAIADAFDAMTTDHVYRSAMSRERAVQELSQSSGTQFDPEL
VIDFSRMLEDRPEMLHGIVADRWLKQLQGDPNTSLWTSTTNDFNEAINPNAKSESYFLNH
LTGKLRDGVAFTDNEGTITRWNDAMRRVTSIAADAMLGKSWCDESIRLRERDASRQENAC
VVFECLRTGASVCRGMLLEKPGSSPVPVHVQVSPVISDSGTSFGSVIVIRDLSDQASLEE
KVESLHHQTTRDSLTGIYNRSYFDDQLAASTKRTAEGGETFSLIICDIDHFKRVNDVHGH
PAGDEALIRFASILESHSREADVVARYGGEEFLLIAANCDNATATKRAEVIRAALEQTPL
PSLGGEPVTASFGVTEFQAGDSPETILARADRALLKAKDNGRNRVIQLGAGNCPSLRAET
PKRGWFGFFDHGVSRQNSEVDILTPVPVDLAIEKLRGFIADHDAEIIRVTENQVSLKVNA
VCTTSGRRRIDHYITLDAQLTLSEQQRNDRSGMPSRKWHGTKVHVVVRPIRNRDRRSRAL
HPCIAQLIASLKSYLMGEVIKDVAP
>A0A4Z0IC07|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E5028|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHLAED
LFDPRELASLAQAMEHDTRGGIRMSSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A7U9NB69|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MTGTKSNAVVTRDVLESGKEAFYSSVLIDNRKYFAYYAPLFNSDGSCVGMIFVGKPSEYV
DGLIWHAIMPLLILAVAVILFAGFFALRFSGKLVGAIRKIEEFLEKVSSGNLRAELDYNV
LMRNDELGGMGKHAVSMQKSLRELIEQDLLTKLYNRRCGEKLLAQVQSEYEKKGVPFSVA
LGDVDYFKRVNDTYGHECGDIVLMYLAGKLGAYMHGKGFAARWGGEEFLLVFQNYDLEHT
VKSLEELTAEIRSSGIDYQNEKDIRITMTFGVVEGSNEKIDHILRGVDAKLYLGKNQGRD
RIVS
>A0A7U9WVB2|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MENTNRKEDSGNIFKKAADYIGKDVKCQNESKKLIVVIRLLLISVIIYFTINGILCIPEW
NLTVILFYCIFFAVFACLFAVSYNYRSIVTLWVFNVGMIIWICSIVHLLGWNIGVQHFIM
VLLILYFFSSYRQYTGKILYAVFLCVLRIMLFYIYHYSEPLIPLSTAKENMLQIINTITI
FLCMSIIAFIFSRDSQELESKLVEYNAQLEKQANTDMLTGLYNRRKAVEYLESLTAKKKP
QGKDYSGFSLCICDIDFFKKVNDNYGHDAGDKVLKGIAEIFREEMKEKTFAARWGGEEFL
LLFPGCNGDNAYMELEKIRRKIKEMKVKTEKEDIGVTMTFGLTEYDFNSDLDLAIKEADK
KLYLGKEQGRDRIIY
>A0A7X3HKK6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. SW-Y-13|TrEMBL
MSWRKLLPSPRWLPREVLMHPHRVVVVGFGIAMVLMISVGARDLYLLRERVLGARQHDLT
LRALGIDAVISAERFKLEFVRDYAQQLISIQQGPDALPTDTVIEEAYAARNHAEWTMAVP
EGDASVVGVSADRLHGLEGFERRDADLRSDLYAARQLSHVLGISQRSNDDTESVVTFISS
NGFYVTYPPLSEAKAGELMQRFSQMPYYRNLLPDRNPERIMRLAPIYTQFESTRQRTTTL
SIPVYVGNRFRGVAALDVDLPKLRTLIGEPEQHGAVRYLMDRNGAIFATSDSRERIDLRW
PADVGARWRHTSLADLFAKGNGMLHVDGQYLLFQQAGGRGNWLIFETFDDADVYRAVFQR
TSLPLLAIWLALPLLMLVTLRVVNHLFSHYLAVGEKLQAMAETDPLTELANRRSFSNRFA
VESARRHRDGEPLAMLMLDIDFFKRVNDRWGHASGDQVLQALSHALRDNLREMDVPARIG
GEEFAVLLPGDTLAEATATAERLRAIVETLGVVPAPDAPPAGMADGRIRFTVSIGVAEAG
IDGCQTLDAMLATVDRRLYAAKAAGRNQVCAADGQDGNAAAPPIQA
>A0A8F8C2Z5|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MLEEQEQELPTLLIVDDERVNRTMLAELLGLQYRVLLAKDGHSALTIASREAHRLMLILL
DVSMPGMDGYEVLAQLRSNEATAGIAIIFITGQSDAAAEEYGLRLGAADYVSKPIRPAVV
SVRVRNQIQMAQQRRALERLAHVDGLTSLSNRRHFDDMLQRTSRRCMRTGEMLGLALIDI
DHFKQYNDHYGHLQGDEALKSVASTLARHARRSFDIAARFGGEEFALILPGNTEPQSLVE
QFRASVAELGIAHSASGTAKHLTVSCGVLTIAQPSPESFEQWLQKVDELLYKAKSEGRNQ
VQSALYTHN
>A0A484XS24|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MLSFAGILFSFVLIALFITLTQRKDFLDEYHKINGNFTHNLAVNYTESILRENDHILGTA
TTFFARNNRLNETLSTHPEEGLQVLMHLQNLMPSVSSISLADTEGHYLRAPEVLPTDKSK
TFDARTRPWFVAQAEASSFSNYTHPYRDYFTDHPTVTVYRPVISPEGRLKGTLAFHLDLT
SMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKRYVSEALMDKMTSGEGHIYDQKS
NAWYYYYSFTNPDWFVIYRVSDATLADITRHETALISWGFALAAIIIVLFGLYLRHASRT
VLMNIINAIKTGDVSQAPRLESMLSHTIQSNKERELAYVRQATHDALTGCKNRRAFDNDM
AELMNNHQPFALALVDIDNFKSINDTWGHLSGDIVLRNVAREGLQVMQPHSVSVYRYGGE
EFAVIFQAERSEASRQLLEAWRSAVEQREWREDNLHVTFSAGLGEWQFEPLEQFVGRVDA
ALYQAKQQGKNRILLTSEI
>A0A5E0ZWS7|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MNAADKLSRPSRVPGSRFVKRMYLMRILGTFLCFIPILSVLIEQNRSTWLMCLLALNAFI
WPTLAWYRARNSAMPLVTEHQNLVLDAGAGGFWIAMMAVNPLPSVVIATIMLTDRLSAGG
VTLMRKAAITMVGVFLVTWLTQGMAVDMYVSQRTMFATLPLIAIYLLALSILTDSIALRL
RIKSRELERIAMMDPLLDIANRRLLEKRIDHELNKLRQTCRESALMFIDIDNFKDVNDRF
GHKVGDALLAAVSQILHLSTRPNDTPARLGGDEFVVLLPDTTLEEAQVVARRIMDAAAMK
KEVAQETVHCTLSIGIACATREMISVTDWLQAADNALYRAKRDGKNRIFAH
>A0A5P9H9Y4|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MPYPFSSYRRHAQSLKGRLMLGLLATWIVVMALLLLFGWRTGDDLLESSNNTHLRYEARL
IADDLTNQAQSRLGALERLGAELDDEQGAATVQDQLHGNAALLEWFDRLVVMGGDGRVMA
VWPEMTGTQGVDLSYRDYFRQVRDFRQPYVSEPFVSFMSEIPMVMFTVPRLDAQGRFMGV
VGGAIHLNGDRLFRRLDRLRLGDQGYASVMSVGGTYLYHPEDDQVLRTVPEDERSDARSL
ALLGWEGEVREPLPDHGIGYRAYRQIWPANWIVSVTLPRDQVMAPLAGWLQRLGWWFVPV
ACLLLPMIGWVLWLTLRPLMRLERQIEQVGRGLRKRVTLKTRMHELQQVADTFNRVEVER
SQALISLQQRQAFLDAVLASSPVGMFVTDTAGNMTYMNPVLIELTGFSRVDDARREWAAY
VHPDDRDTLLELWRYHMASGEGLKQQFRYCRQGGELLWLEVHAGPVADGGEALGFVGTVK
DITARREEEAMRQWEAEHDPLTGLLNRRGFERRLEEALVDWRKTGTPSSLILFDLDHFKP
INDEGGHALGDVMLRRIARVIDREVRGSDHVARQGGDEFAVLLPSCTPQHAEKIARALVD
AVGRVDVQHEGRTYRVTLSLGLTSLREGDQRIAAVIERADAASYRAKRAGRNRAVVCHEA
SDDGSLLK
>A0A411ZCL9|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MSEHESAFADEPMGLSTAAVLGLDDAAGEHWPRLRGLQFSTLARVTKYRMIMHLTLAVLT
AAVLHGSVAIWWLAPWAAALGYVHLRGMNFDNGLADTNKRRITKEEFHQQLITPVASGVL
WAIPLLFFAPQAGGVESAVVWTIVAILITGSTLFYTAAPLGIVVFGTIVGIAGLVSLIMQ
GLYPMAAAAFTFLAISLFGSVEAGRMFLVARLAEEGVAEKDQVVSLLLREFEENEADWLW
EVDPTRRVRGASPRLAYALGRHQSEAEGRPLLEMIAGEGWDTGRMPPTLHELADKLKNQQ
SFSNFLVEVSIRGDRRWWELSGTPILSENGRFTGFRGVGSDVTAQRESSDKIAYLARYDT
LTSLPNRLQLTETLGEALQWADQWKTRCAFLMIDLDRFKAINDSLGHLVGDRLLAQVSAR
LQALMGEGQLCGRLGGDEFAVVIRDATDHRIVARVAKTIIESLSEPYIVDNHTLYVGASV
GSAIGPRDGRSVEELMRNADLALYRAKDEGGNDHFPYEPNLHLVAEERRQLELSLRKALD
NNEFRLDYQPVVDANKEHAVSFEALVRWDSRDHGFISPAKFIPIAEDTRLIIPIGRWVLH
QACLEALNWPEHIKINVNVSPEQLLDPSFTDDVVRVLSETGLRPQRLEIEVTESIFVRDA
SIARSALEQVMALGCNVALDDFGTGYSSLGYIRKLRFSTIKIDRTFVQGAAQQSAESLAI
IRAVVAMAQSLEMTTTAEGVETPEEAKLIRELGCDKIQGYYFGRPMSASDAGKIFASPQQ
KAG
>A0A4P6M0N9|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MKQNKKEKKGSQWEVSFSPIIRYSLVFCAFVTAFILLGGALLSVSRMRSDAKASLNSSQA
QISQRVTGAINLLESLASLPDYYDPEIPPIDKVKRLDRLSPYFGYMMICYVDKNIIVYSD
GAEPASLASRDYMQQLFATGQRQVTDSFAAGADGTTLNYTVAVPLKDQQENITGALFCAI
YFDEAVQILKESAGSLRADATLIGSKGQIMSSTAGLTYGDSVMEALRDDTLFGVTSDRLE
ELMLAAQPGTYWSIQDGSLCYTAYRRVDNTNWDILCTVRFETAFSQVFPFLCIVASMTML
ACIGLMVFIRKYIAKQMVVVDTLVQSMGELEKRVYQSERPESVDFQEILRLTSDGLSDGL
TGVVTRTVFLNKAEAHLKNADPEKFKALLFVDMDNLKYINDSCGHDGGDIALKSVGYILR
EYEKKYDGVVGRYGGDEFVLLLTGLDDQKELRAVLDGLILQLQSKIQSGGQNIPVQCSIG
VSIYQPGMKLEEMISNADEALYYVKQNGKGYYHIHQN
>A0A7U9XG28|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MTNTIIIYSFGWNIGVQHFLAVLLILCYFSCYNQYRWKIKYAAFLCTLRIWLFYAYHDKV
PACQLEVSQENILQVINTVTIFLCISMIAAVFSNDSQEFENRMVIYALKLQEEAYTDTLT
GLYNRRKALEYMDYLTKEQNKGFSLCICDIDLFKKVNDTYGHDFGDEVLKEIAKVFKEET
KNKGFAARWGGEEFLLLFPECSGKDAYIRLLNIRDRVKALKIKKEDTVVSVTMTFGLAEH
ITRNSFEATIKEADKRMYFGKENGRDRIVFND
>A0A1W6VI47|diguanylate cyclase|EC 2.7.7.65|Vibrio alginolyticus|TrEMBL
MTLYKQLVVGMVAVFILLMTSVFMIEFNTTRGYLEEQQRSEVNNTINTVGLALAPYLEEK
DQVAVESVINALFDGSSYSVVRLIFLDTGDDILRSYPVKPTGVPQWFTNLNLFKPIHDRR
VITSGWMQLAEVEIVSHPGPAYTQLWEAFTRLVTFFGAIFLLGLISISWILQRALRPLSL
IIKKMNQIAKNQFGEPLARPKTKDLILVVDGINHMSTQVEQAFKNQAQEAQRLRERAYID
PVSQLGNRAYYMSQLTQWLEESSLGGLAVLKAEFISEEYDDKGYQEGDALVHQLAEQLQA
SISSPDITIARISSDEFGFIMPNIDENELKLVASSIVNCIQNLGSDPTGMANPHIALGVT
YSKKRKTSTEIMSLVDNALSSAKANRELAYGYVTADDHGAVMGKQQWRMLVEEAIINDLV
TFRFQAANNSFGKTYHQEVFSAIEKEGVRYGANQYLYALEQLEMSHILDQYVIEKMIDKL
NAKELTSPVAINISPSSISQPSFIRWIGKSLEKNASIAHLLHFEIPENCFVNVPHYTALL
CNTIRNADAVFGVDNYGRNFQSLDYINEYRPSYVKLDYLFTHNLDDEKQKFTLTSISRTA
HNLGVTTIASRIETQTQLDILSDNYVEVFQGFIVDK
>A0A1J1LGR6|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MKLRLIRYGIHKILYETSFWIGGFVGILIVSAIEISKDMGFWVPIPFVIMGFSVILCANL
GGLKTGLACTSVISIYIIYIAWIKWVPSVFTPEPIRISLVILLILITAILLGRTTDKKNL
VIQTLKTTQNELKKRVLELAETNALLDRENQERQQAEAVLQSLILETASVTGVEFFPALA
QHLGLTLGFRYVIVTEVIQEIPGRVRTLAFWGGDHFLENTELDLDQTLCNEINKTRSLTY
FSDRVQELFPHLSFLVKLQVISSIGVPIISHSEQIIGYLCLLHDQPIKNEDRIQSLIHIF
AGRIVAELERKQAEEAQQKAEAKYRSIFENAIEGIFQSTPDGYYLSANPALARIYGYDSP
EDLIQNLRNISEQLYVNPKERQEFTQIMLEQGQISGFEYQVYRQDRQVIWISENSRSVYD
NQGNILYYEGTVEDITQRKLAEEKLLYNAFYDELTSLPNRALFIDRVQQSLTHSQRRSDS
LFAVLYVDLDRFKVINDSLGHAVGNQLLIDLSQRLINTVREGDTVARLNGDEFAVLVEDI
QEIEDATQIAERISLTLSQPFQLEQQEVFTSASIGITFNFQSSGHLYESAEELLQDADTA
MRHAKYLGQGSPQLFDQRMQKNFRSRLQLETDLRRAIERDELLLNYQLIVSLLTGEIAGF
EALVRWNHPKRGLVSPVQFIPLAEETGLIVPIGEWVLRTACKQMRQWQIEQLVNHNVTMS
VNVAGRQFAQLKLVNMIQDILQETGLDAKLLRLEITEGVIMEHFESATTQLQQLRDLGIQ
LSIDDFGTGYSSLSRLQQFPIDILKIDRSFVSPLGSKAENREIVETIINLAVNLKMSVVA
EGVETLEQILELKQLGCHYGQGYFFSRPLDSEGIKQLILNHQFKYL
>A0A1J1LLQ2|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MGFIYHLLENMKIDDQEKDGQKSLRIICAVGLVIIVATVLGIELFYSYQFKARNTEQNIR
NIAQLVAQNISYKLNSKQGLSFFQKNFDSSVLNREIQGINLDNRGVIEIIDLKLRLITRE
PHLSSDKNRLLQLVALQKFIKENQSQKIEILISPRDGKKSIYGIQRIEGYPLIILIELPL
FDVFLTWYIKVMIYGFLFLLLIILLMTLIKRENNYLQQTQELMTRFVAMESADDMIVITS
KDGTIEYVNPAFTKITGYQANEVIGKKPSLLKSGRQNKEFYQRLWKTILSGKGWKGELVN
SKKDGTTYYEEMTIAPVKNSLNEIIRFVAVKRDISDRKQLEAQLAWLAHFDKLTGLPNRV
LFFDRLERAITQAQRQQTRFAVLFIDLDGFKLVNDCLGHQSGDLVLQEVAKRLSLSVRKS
DTVARMGGDEFTLILGNISQKNDVIKIAQTILLTLSKRCVVNGHECQIGASIGISFYPDD
GTDLETLVNKADAAMYRGKHQGKNRYEFASTEESVTVCINHFIPLSDLETQGEGEKGTRG
LGD
>A0A128F299|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MTPTAATNQSSDVFPENAVLIRIMLLFLGCLIESLYSIYFLRQPNSAAFIWYTNGFSIAM
IALAPSSQRLALVGTAFVAILLSNIIFGDDPLQSIQLAAANSSTIILGSLSLAYIARYAE
PFLSMKAFTSFVLLTVLLSPLAGAVLGGWVLNRELSIPFEAVAPAWYLGDVIGILAITPL
VYTLLQSNRELPSSLCRPTTVMTIFVIAALCGWLLTHATFPFIAIAIALTVAGAILDRLS
AFFTAFVVSVTLDLLLVNPEENLVISTEPVSTTGLLLPISGAMLLGAILAVKSARLLQIQ
KTSDERADLFSNAMQSSVIGTVMVQPDGTMSNANKSFIDLIGYTAKELEKKTFRQLVFHR
DKDAANEQLQLLSSGKINNFQTEVRLTRKNKQVVWTRIGVSIIRDKWTGNTLQFIYQVQD
IDKDRRFDDERKMWSKKFEFALGINRTAVYEMECHTKYLHLSENASQAIGIKASDVKRLY
EWMSRIHPDDLREYQHTVTYNGGQFGAIEYRLLDDNERYRWVRDHCQPIEHDSHGVTTKV
IGTITDIDDERELSLQEALAAKQAELVGQVCDFGLWEYNPETEEIYWNTEMYALYGLQES
DGISRSLWRDKVLPSDQHQLEAMFTVARMHDEQLDINIQVRNANGQVVYHHILARVIHPD
SGSRLVGLCQETTTIHRENVQLERENLLLATAAESVSDGIIALDSLLRITFINRHAAAFT
GLSNNDLIGASIDEQFNIFDRQNQYTFAHLLSAYHQDFRLNGTFTLQTEQHQEQLVYLEV
IPVIPDGNAPNGWVLTFHLHTVSMEERIAGKEEKSALDMLTKLPNRRAFEHKLQGHIDSL
EESLDRHTLAVVEIGGLEALADAFGNQIRDQLVKSAGLIIKSFGKQNAARLSDKQFGVLL
PNESIENAQHSLNKLSEKICSLKYQHGETSYPLDCSIGLTAAEALQSTPFQLIYQAQVAL
ESLTESCKPAISVFDPSLLNDGISFRRDFLLQRIDTAISTNSFSLLSMPLVPNSQELPTW
HEVLVRLITEEGDLLLPAEFLPAAEPTGRLISIERWVFNEVLVEQANALAETGLGIAVNI
STGAFYSESFMSYCLGLIKDSVLPASQICIEVKESTLLIDTIRSQDIVSSLRKLGCEVAV
DNFGSELSSFGYLRKFNISLIKIDGSIISMMKSSKVDKRIVESIKQVADTLKVKTSAHKV
NSEEDLRHVREVGLDYTQGYVYGEPIPLGRVISSSKAGIRNPYEKDAASNRKSAG
>A0A679KIT5|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MLGRLADKISLRHQISLFAGAVGLSIVAASTLGSALLARGQATDMAQNALLQVARSVADR
LDQDMAERLREIRNVAALDPLQPHWMEETGSLRKVLQTMQKTLPDYAWIGFADETGKVRA
ATGGILEGANVGQRPWFIDGMKGAVAEDVHVAALLQSLLKPSGDKTPFRFVDFASPVTDA
SGRIIGVLGSHLSWSWADVVRREVLSSRRPELKEEIVVLDRTGRVLLGPDLGTTPYSPAD
LAAGHFIASGPDGKRLAAVSATRGRGDYSGLGWIVVALQPEDTALAGANRLTLLITLIGL
GAGAVGVLGIFLVVTRLSRPLVNLTDAVDRIGREPNATMTERVHGSPEVLRLSAAVRSLL
RRIGTAESDARDVETEASRAVQAAQDRVRRIGDDLHALQLIANKDALTGLLNRRAFLPLA
KEALNAFKLYRRPIAVLMIDIDHFKRVNDRYGHPAGDVVIRKVGSIISDTIRTTDKVARF
GGEEFIVLLGDSSAVGAALIAERIRQSVASTVFEPDNNRLLATISIGIAEADSSDKDIDH
TIERADRALYEAKSRGRNCIHTFTADIADLRSVA
>N9N259|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 51.11|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLHDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQEIMDCTDKNNMLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A4U6MNR6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. TBCS-14|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A4U6M046|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. TBCS-14|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNAGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A2X4V5A5|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MHTTQSPDTTKLQPALTVFMLVFATCIFGIESRPIGFLAAFWPSNAVLLAVFVRYPELVS
RLGWVMAILGYLTADLITGSPLDKALLLNGANIAGVVVGYQLFKLVPPQVKTLERTSSSV
YLFAICLASAGTTGVIGAGASVLLFDREYFPALALWMSSEFTNYITLMPFILALPGDWRG
YLRSVVHGIIRPGSGRKLAVLVLLALACIGSILIGGPGAVIFPVPILLWLAMSFSLFTTL
VVVLIYVLWCHLAIDLGLIAINVDMKALQNTVSMRLGVALLALGPIAIASMNFARNALLR
QLEHVANHDALTHVLTRNAFMQRGSRLLTQKGEQVCVMMLDIDYFKSINDRFGHSGGDAA
LISFTRAITGDLRDSDLFGRMGGEEFAIVALIERQEDAVYLAERLRRRVEIESIAMPAGN
HLQITVSIGMVTCIGGTEQNLDNLLKIADMAVYKAKNSGRNRVATPEISPLSYRDR
>A0A6P2FB00|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. PBL-E5|TrEMBL
MSSASDLESMFDLAPVSLWLEDYSGLKRLFDQWRAQGVEDLVAHLGAEPGRVQECMSRLQ
VMRVNQSTLTLFGAATQEELLSRLDSVFRGDMADSVIHEFDLLWRGQLSFDNQTVNYALD
GRRLDVHVHVRVLPGHEAAWDRVLVSLHDVTERVQAERQRAESERYARGLFDHSPVSLWV
EDFSAVKTLLDDIRARGISDFATFIKVHPEFVTRCMQEIRVIDVNHETLRMFAAADKNTL
LRHISRIFRDEMRESFGDQLQDLWNGKTLQQREVLNYSLSGEPVNIHMQFAVLEDHLDTW
DLVLVSLVDITARKKAEAYLEYLGKHDVLTQLHNRTFYTEELNRLSRKGPWPVSVLAIDL
NGLKNINDEEGHAAGDALLRRVGEVLSKAVDAPSWPARIGGDEFAILLPMTDERGAEAMR
ERVMSLLDLNNQFYAGQNGHVLSLAIGQATCSAGDQLDLALMRADKAMYEDKARHYDGHG
APGYA
>A0A2S6U5T3|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha4_Bin1|TrEMBL
MTEATNQAGPAAQDTGEILHGIDAAIDENAEWMQRWHRAIICGEAPDPSVVSQYAQFLSR
FGSWMDLNRDQGLLDQAAFRALGRAHEDMHEFGRFLALKAAEGEAIPTVEYGAFVEKVRL
FNTQARRIRDAFRMAVSELDPLTGVPNRQIMMQVLERERERALRTGVPCCIVLADIDYFK
AVNDSHGHVAGDHVLRTVAGRFLANLRRYDEIFRYGGEEFLICLPSANAERASEIVERLR
QSLANAPVPLPDGGELPITASFGLCLAAARVPLKQTIEFADAALYQAKDEGRNRLRLWQP
GEPA
>A0A4R0FRZ8|diguanylate cyclase|EC 2.7.7.65|Enterobacter quasihormaechei|TrEMBL
MNKDVISTPRPTFKRTLRRISMISVVITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVS
RWLFPLPVAQPIMHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILIASAVALTITRSL
HHGMVAEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTEREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENGSVEALLEQADRNMYLVKNQRSKTIS
>A0A3S4GE58|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MCGTPADSAITAMSRVHERLNTLRLPGAPQVVLRISVGVAPLTPQIGHYREWLKSADMAL
YKAKNAGRNRTEVAA
>A0A1V6H7A1|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MSITISPQAVADQLAAERWYRHGWAFTLWDYVAGHPVLLAHWGGVPAPPGSEGTFDNHFE
VGERQLLAVMRPLLPQRRSHEPFGMAGSVLGLTVLIGFMVWRLDHQRSLADWLSRTDPLT
RLANRRELERALEEALDSGVSVSLILADIDFFKSVNDSFGHAAGDRVLQLVADALRRSVR
GGTDRVGRMGGEEFAVLLCGLEEEEIVPVWRRLHEQIDALEPQLPKPVTLSVGIASTCLE
EPGTPLRSGVLSAADRAELLLRNADNALYEAKHRGRDRAIILRHGAFETPAEPPAATT
>A0A8J7VGQ5|diguanylate cyclase|EC 2.7.7.65|Proteocatella sp|TrEMBL
MKKRDILAEMEKLRGNQDYCIELCDAIFNMPQAEYIEILGELVDFARNSRLDFAYPWFLY
KMGCSFYSCSEIERAIDLLEESCRIFEAENDARGMLNASVALISVYSCCFNFEKAVEISI
SAIELATDKNDYEAVSVLKADIVAMYIDMEDYEQARYLSQEIERMSYIGSISNDFIINLN
RAICEMKLGDMGEAQKYLERAEVLLNDRNISLRYMLLQEKANLMKLRGLYQEAGFTYEES
AYLAEKYGFTSGLAEVLLDWMDMDMMRGRHESAVKKADQVMSIIEDDCNCRLKRKLYSQM
SALFKARGDSEMALFYLEKYMETEKMISEALKSPSMKELEIKRASDRASTYMAISRQKDR
IYESLGRIMSNLNEDGIFAVIAEEIQDICSPDIIQIVSYDESVADYEYKISVEKGRRLKV
DNLPVESNTFSGYCIRNDREIFIRDMENEHSRYINNFGEYIEDVRKLQTGVETEVSVDIP
NSAIFVPVRFHGKVTGVISIQSFSKDAFSLEDLSTLKVLAEYSGIALNNALSYKKLEHSA
NHDFLTSLLTRSSILKTGKEMYECQERKRSDDGMCILLIDIDDFKLVNDSHGHTVGDIVL
RKVADIIRYSVRSDDKAGRYGGEEFIVLMNDARREVALEAAERIRRNIEDDSMTIVKPGV
ELSVTVSIGVSGTRSGEKTVDQLIEEADEALYRAKAEGKNRVSEYYNYNE
>A0A8G0WSS7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MIDNRSGKGLSFARRIYLPRILGMGIGLFSVMAAMAPLHPPGWIWALMLVNGLLWPHVAY
LWAKHSTAPYRAEQRNLLLDSLMGGFWVAAMHFNPLPTVTILSMMTMNNVAAGGKSLLAR
GLLGQLAGMLLASAMLGSGLQLQTSALQVWACLPMLALYPVALGWVCYRLAINLADHKRQ
LSALSRTDSLTGLLNHGSWKDLLLLKFQISRQQRLPAMIALIDIDHFKAINDTYGHVVGD
CVLRHLSQELQRSLGPDDQAGRYGGDEFCVIFPGADQARAGLAMEALRERVNAYRNPQLP
MLRISLSIGLAAYDELLKSPEHWLEHADKALYAAKHQGRDQVSFNHGPAAPLRLAYPD
>A0A0B0HLR8|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus sp. BCO1|TrEMBL
MNDTYGHDVGDAVLVRMCEAISNRLRDCDILARWGGEEFIILAPATSRTGAYRLAESLRH
LVETVHFPKVGHITCSFGVCEYEQGMTKEQMVKRADEALYEAKRGGRNRVVVSE
>A0A2U3N031|diguanylate cyclase|EC 2.7.7.65|Acinetobacter stercoris|TrEMBL
MKFHWLNLTHLKIQRFMSESVIVNWSNVSKGVLILVLGALDHILWLAWYWFGYTHDVLHH
WLSKSYFAGHLRYLIVVITVFIILILSCFLFKNNKFFQKYFPYVAVLYFGLTFIKGGYTI
GIISPATIAGYISLISVGLVLFERRIIYFTFIPITIFLLIAIYLSATERIDYAPIFSEEL
KFSVLYKNDFWVSSMLFLYVPIFFASIVLFEILLIQWKNREKLFNEMSLIDPLTGIFNRR
SIANHLKCIQEKNIHYSLILIDLDYFKNINDTYGHDAGDNVLKNVANILSQNLREKDLLG
RFGGEEFILILNETNLTQAVAIAECCRQNLQKKPIVINRLHSIQVSASFGVAESLEDLSN
EIVIHRADQALYFAKANGRNQVRYYQELEQRHPPHN
>A0A1A8TFZ4|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MKQISLWGLIVVPFALLATLGGATVYLFSTVTVSNVSDNVGLHYVHEIEARVYDRVTELI
EPLNTIAQLNRDALVHHPEYLENLDFLAGRFYEQAVSYPYMTFISLATADGRYVNSTRDP
FGSSHHIATNYTTEPNSLEAFYYDPVSFVGARIETEPSFKNYNPTTRPFYQDAVVAGDVV
WSSIAPYFGYQSLGVGLSAPIYDQDGKLLGVTATSVALVALDKYLQSINLVDSAYVFLAE
QNGDLIASSRKVALFNNDNGVSTRLSLSAHSDQVFQRAGERFAPGTQRIAVDGETFLYHV
RPVELPYGQTWYVGVLIPESYYKGILTEYSQAMVLIILLIFVSIALAGSLIARFIGRPIL
LLNDAVNANSLERIREIPQPLSHVREVNSLGEGLQGMAYKLSDVLQNLEQKVAQRTSHLK
DENELLLEQSSTDELTGLYNRRGFNLLSEQALRQAAQFDQSFCIVLCDIDHFKRVNDSHG
HSVGDQALIGVAQVLQSHFRAHDIVARYGGEEFMLITVNMSKEDILVRLNSVRQSLITQP
VLKDLPITLSFGMTHLTPPIEMDLEALVNDVDAKLYQAKNTGRDKIVG
>A0A7S6UEK2|diguanylate cyclase|EC 2.7.7.65|Lysobacter sp. H21R20|TrEMBL
MNTSSTRSSTATTVQDTQVADAWHALLDDVAQEQVALLRELAHSAPPSLAEHFYAGMLDD
PRASRFLSSEQVQSRLKPSMLRWITNLLTSGPDDVDAQIAEQRLIGDVHARIGIPVDLVI
RGTRMLKHQLYRHIINVAPPELASATIALVSDLFDLALEMMSHAYSVARERSTRLDASYR
MFSLIQNIGTERERQRALLLDWENALLYRYASAPVDVGTAPQLAQSEFGLWFSHKGLPSF
GDTAETRQVSALIASIDDLVSSPGENPSTSLPSIRAQLAQTRALIGMLFDNIGALEAGRD
ALTSLLNRRFLPTVLRREVALASESSGGFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
NLAQHTRSSDYLFRFGGEEFVMVLGSVSADQAVAIADELRERIAASPVTMSDGSKVPVTA
SIGVAVHDGHPDYERVLARADAAMYQAKRNGRNRVELATAAMVEPPGSRLLSAR
>A0A554WZP9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MGQVLEHLEQLARLTRGRDRDSMDATLVEVLLPLLDARCVVLWEAVPEDAGERLLTRARL
ERGMTVPQSSPPWVSLSDLPRVDDDPVRVQAWLARQTRVVADGAMHRVLVPLITESDRRL
LIEAVLERAPDVHAVRVVEGVARIFENFINLLESSERDTLTGLLNRKSFDDTFYKITRRT
PVLPDADGGQRQGQEAAQHWLGVVDVDHFKSVNDRFGHLIGDEVLLLMARILRSTFRHDD
RLYRFGGEEFVVLVRAADSAAAAGVFERLRRNVEQYPFPQVGRITVSVGYTAVREHDTPS
DAFERADRAVYLAKAEGRNTVRCYETHVQLGEPTPQRGSDGDIELF
>A0A5P3VLY8|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MTPDTAPPSHQAATAPSTAPRRWQPLLMAGAGYFALAAVGLWLARLPGNVAAVWLPNAFA
LGLLLHRPRRETPWLLAGMLGANLLANHAAGDSTASALMLAGANLAEILCATGLLRLLER
HAGLVRHGPLASFAVMLAVAGIVAPALGATAGAAAIARLHGTPFASVWWTWWQASALGMA
LLLPMMLSMTPGRVRAAFARPVLAPQAGLLALCLAIGALAQWQGHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLSLQALMLAGQDHEAVPLSAAVIMVLPVCIAYLTEQNRHGRASLR
SSEKRFRQAMEHSAIGMALVGMDGRWETVNRAMTELLGYSGEELRAITFQQLTHPDDLSD
DLRQVALLVDGEIESYRMEKRYRHKSGEYRWALLAVSLVRDEDTGAPLHYIAQVEDIHAR
KLAQEELERLSRRIQLAVEAGGVGIWEWDFASAVITWDARMHALHGTDPGRGAPQSEQWI
AMLHAEDVSRVSAEMRQAIRGAAPFDTEYRIRRPDGAVRHVRAMAMVSRGADGMAHALVG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDASMHVTFMNPIAEQLTGWTMGSA
SGLPLERVFRLVDEASGDPIPSPVESCLRTLTPAYLQDGAVLQSLTGERHDVQDSAAPVL
TAGGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
RAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYLIRNHVRPDDLLARLGGDEFALLLKDC
TVDQAEQACEGVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPASTGRGEH
RHIEILVRMVDESGEMILPGAFIPAAERYDLMGHVDRWVIHNVLHAYGERLRAVPGLSVS
INLSANSLGEPFLLPFLHAELDASALPASRIRLEITETALINNMAAANRLVTDMRRAGCT
VSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVKTVA
EWVEDERTLDALRAIGVDYAQGYAIGRPIPLEAFLQACGPRGVEQQQGA
>A0A485M3B2|diguanylate cyclase|EC 2.7.7.65|anaerobic digester metagenome|TrEMBL
MARKPTYQDLERKISELNMRLGDYRERFAEISRNITEFVFEHDLEGNVTELNPHYTGRLG
LYREDMVGKNARSLIPKPFRKQFDDYLKRVISNGKDEGLMQVVSKDGKSHVIEYNNILVT
NKDGKKMVQGVARDVTERLETEHALIESDTRFRIILDSIEDGYFEVDLAGNFTFFNSRIP
EHMGYTEEEMMGMNYRRLMDTANAEYIYNVFHKIFITGESVKSIEWELIKKDGSRFIADT
SVSLKRNRKGEPVGFQGIIRDVTERKRFEQELAYMAYHDPLTGLFNRKAFVEKLTETIRE
ARRYHGRRAVLFLDLDSFKKVNDIHGHEIGDRLLTEVAARLRRAVRESDFVCRLGGDEFS
IILTNSRNLNAELVAGRIVEALCMPYHIMGITIDFISTSIGISIYPEDGLDAEVLLKRAD
EAMYHAKERKSCFVHCSEVRDTPSPAP
>A0A0P9FXJ1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MKIVLKPWQFNLITCCIYLLFAIFTMQALHTLSTWPPAGVALAAVTLFGRKAWLGVALGS
FLAIIYYFHLYNLNPFTFNHFAINLATSTGNTLAALCAFNIMYKQIVLHNPLKRVENVAG
TFIFACAAMGMVSAIFGVGIYYVLGLEWFDGFFFGVLNWSISNALAAIAISPALYFLWRR
WPHKMTTQNVTQSLLITAITVLCCYLIFGPGYTHLDLPILQPSLILFPLLYCAMRLSSTL
TSCMNMLVFCLAWIGSNQGWGYFYEHHAGDAEITLQFFFLFIFAVVLLVQAVFNQRQDEQ
EELTRLLEQRVEERTCQLEYQKQKALKLAVTDPLTELYNRRGFFRTAHHLFSQYLRHPGS
CALLLLDLDKFKLINDNYGHAMGDEVIKNTADILRHFTRESDITGRIGGEEFVVFLPMST
QDDATSLAERIRQAISEQQVTLDNVTVQYTLSIGVSTFDQNDKTLESMLKRADKALYLAK
NQGRNQVQYC
>A0A6H2GCP6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X2HK02|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MKWLRKNRSGQSRPTLGRVLQRVHLGLALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFEDRTAASEALVLIASKEEVSEARILNNSGKVLATWRHPEDGPLHGMEQ
IVARWALPEPVILPITHEGKEVGKVWLLGHGGSLLRFLLRGMIGMIACLVLSTLCALVLS
RRMLVGIVRSLDDIANVAHAVRRDRAFGLRVPSAPIAELHELSSDFNGLLDELEAWQAHL
KQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIKPSEKLAVLFIDGDRFKEVNDSYG
HAAGDVVLTTIAGRIRAQLRESDLVARLGGDEFAVLLAPVHTTEDVLQIADNIIDCMTQP
VILPNDEAVISSLSIGIALYPEHAVTPQGLLHEADDAMYQAKHRYNGGWRLAIQK
>A0A0U1K9V4|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MSSIKKQSATRAPDHHNATKLPTLGRVLGRIHLTVVLVSVTTAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDKVAANESLSLIAANEEVAEAKILDVNGREMASWTQPDD
GPMHYLEQNVARWALPQPVVLPMVHAGNEIGTIVIVGHGGSLLRFLLQGLAGLLACLLLS
TVVALVLSRRMLFGIIGSLNQITDVAHNVSRNRSFGQRVPSAKIAELNELSSDFNGLLEE
LEVWQEHLTQEHDSLAHRAAHDSLTGLANRAFFEGRLSRTLSDCKPGDHAAVLFLDGDRF
KEINDNYGHAAGDVVLTTIADRIRALLRETDLVARLGGDEFAVLLAPIHKTDDVLIIASN
IIESMSQPIVLADGREITTSLSIGIAIYPDHAQTPEALLQRADEAMYQAKKNIQSGGGRV
IAHPSDTPLTESLG
>A0A380AL87|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MRSRSPTLTPKKPALLNWLLQSSHQADNAQFQRQMRLTLVPSPTTPWLNAAGVALLLLAY
GWLSNLAIAAALLALLALLTAGRWWLARVTPPIRPTAMLVTVLLWCALVGAIALLAMLSG
RMLLILSAGLLITALAFWLMQRHAAAPRFALLEIMLLTLPYLLAAPLSRVQNLFLLADII
PLWLLLAYGLIAFYHRQVAQYVTLTAEKQKAAHRDHLTGFLNRAGGEAVMQEICHPATTI
HPLSHLFIIEFTPLAALYQSHGVLIGDDVLRTIGERLKMLVRPSDFVCRYSGGQFLILVH
GLPYGSEGEFLARIVPPLEVPYDFGAFGEVTLRLNTGVLALTQDYKTVASLMTAAQQALG
IKGKD
>A4YAH3|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)|TrEMBL
MPTIGTEKYTAEWLALVNNLSRSDAGQLEHLIHQNQHALSDTFYQAMMQDSSASEFLSND
LVQKRLKASMQQWLTDMFQSQTTEHIQALVAQQIKIGEIHARIGVPVHLVLNGARYLKTR
ITQLTSHALASHASILIDLAMEIMSQAYSNSHERNSRSEEAYRLHAIAQNIAHEKDKQRA
AFLDWENKVMFDCASGVDAALLQPLYSSEFGLWFRHKAEHAFAGAEEITLINDGINHIDN
VLLPLLALPSLQADTKKLQCLRELREQSKSIRYYLDLLFEQNREVESGRDVLTRLLNRKF
LPAVMTKEVNYSRRNKSQFAILAIDIDHFKTVNDSYGHEGGDLVLQHLAALLSNTGRGGD
YLFRLGGEEFLMLLVDINAREAALSAENIRRKVERETFLLPHNQQLQITVSIGLAMYDGH
PDYQRCLRAADDALFAAKRAGRNCIITAIDKADS
>I4EY43|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MGEEPAPARPATVSVPAVVLDGLARATLEATAALVVVCDGQGTMLLANPALQRFTGSSED
QLIGRPFWEVVTLPEEVALARTAVATVLSGAPAIPGEVDWLSGEGVKRRIELQTSVLVHE
DGRPYAVAFIGIDVTVHREREAEVQRLAMTDALTGAANRGALFMVLGAHLDPGSGTGCGL
VFCDLDDFKAVNDRHGHAAGDRVLVAVAERLRELAGPDDVVARLGGDEFVLLCADGDEEA
LADRVRRFDHLMAQPVEVAGTPVHVGASTGTAVGRPGDDPDDVMLRADLGMYGMKTRRRI
RRASRG
>A0A7W3F646|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A7W3I5L6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLDKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDARLTTTLSPHHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAIIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKGNGRDRVEVYQE
>A0A7X8S101|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAIDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLGVLLSLPV
LVVYPLLFAWVSYQTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7W3F6N7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAIDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLGVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>I4F0M1|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MADHEQVRTEKAAAGRLMGKAETQRLRRMWIGSSLRRRFLLSVGLMLLPLVNLAAAAWFS
VSQMADSAQQLAGEAPATWLEELAAVSAVRHEALLAVFGVCLGGVVLAALVGRRLAHSVL
GPLLAIKQAADQLGRGNLAHRIASGRADELGDVARAFDGMAQRLQISQDQLAHSATHDLL
TGLPNRRMLHERLRQASPASGPASGLASQDVWALLLIDLDKFKDANDSLGHSAGDQILTV
IAHRLQQAVPEPGLVARLGGDEFAVLVAHADGPDGAVAGAEQCQQLIERPVRVAGRDVVL
SASIGVVADLGAAGGDPEELLRDADLAMYAGKRAGGGRSRLFSPDLHRRALARLELEVEL
RQALSHGELRPVYQPVIDLITGRTVGVEALVRWFHPRRGVVPPDEFIPLAEESDLIVALG
QQVLIRACTEMASWLRAHPDALPLMLNVNISARQLQHEELVDHVQEALRISGLPAGQLTL
EITETTAMTDPEASLQRLRALVGLGVGLAIDDFGTGYSSLAYLQRFPIQTLKLDMSFIAG
LDTDPDAVRLTGGVLRLAETLGLRVVAEGVERPSQADVLRAMGCPAVQGYLFGRPGPLTT
ALERFRQPDTQLQLTAGS
>A0A336QN59|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSDMILARVSQSLATEQSVESLVRQLLEMLEMVTEMESTYLTKVDLDARLQHILYARNSK
QMQIPEGLSVPWDETLCKRAIDENCLYSDNVPARWPECTAARALEITTFLSTPVHLPDGT
FYGTLCATSRHQHALSPRGEQVLHLFAGLIAQSIQKESLVAQLREANAALIAHSYTDALT
GLPNRRAIFENVETLFSLARHLRQKIIFAYIDLDDFKLINDRFGHKVGDQFLIQIGQRLL
RECGDNDILGRLGGDEFLVVSLSPEDDRDPRDRLQQVKNQLQQQICGDYHLGDIHLFYPG
ASLGVVEINPLETDVNCALHLADSAMYEDKKRQDKTTFVVH
>A0A7W3I7Z5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIMGENSHFVCRFGQWLNN
QSRYNEDDCSYVSKISATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDVLTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
SDGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDIND
ETSYPLSA
>A0A8G0WJY6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MSGFVAWLRSVTDSFFSSLAAKRGVLILALLVQGTCAGVYLYLEHNWIEARVVQSLKNVS
SMHLRSFDQLEITLNYQLSSIGEAMGLLGMDLPRKQALLQKELKQAWLDTVIVLDAAGNI
VTFATDVPLSAALPPSVLAASSYKNWSRYRAFMDSGAETASFFVSRPQIPELRGGGIVMY
RRIKSTQGDLLGSVVGFTSLHSLSNLLNADVARGFDLGKNGILNFIDRRTNKILYRYMYS
NDPAEVYSGGLIPLGGASFQDSRYGAEVKFYRSPVDGLERLAVLAPMHNDQWLQLVGASK
DEYLFNWRIQVIFSVFAFICLCILQWLLVTFIHQNRAQRALLDLVLDTMDAYVYFKTSER
RFVYANAKTADLFGLPAEQIIGRLDREILPPKVADDFWVMDRQVFASGTKQSATEVVTTP
DGKKHYYASIKVPVQLPDQPLALIGFSTDVTELHEQTIAREAAEKELVAHNHSLRLNNLV
LDKLAQNATLSEVLNAMVCIIDDYRVGVSGAVYLVADNGKELIGCVAPHLPEAWFGATAR
VPIDDMNGSCAIAVSRGETVIVEDIASDSSYRGSTREAILAFGLRAAWTQPIKNNEGTIL
GVFALYQRQPAAPDIHDLALLVDYSKLAQLVIERSRLAEALAESQALYRLVAENSNDVIW
VVQYPSMRYSYISPSVEWLRGWTQEETFNVPLLQSMPPDSVYLWNEVVAEHLRRIDEGDL
TGRFIGIELSVWHKDGHRVPVEVVANIMLDNACRPTHIVGSSRDITRRKVAEDTIRKMAF
YDQLTDLPNRRMLEDQLAKMLALANREQRTLSLLFIDLDRFKAVNDQHGHEAGDWLLKQV
AVRMCSVLRASDTASRIGGDEFIILLPDAHKTVEALQVAKKIRRILEKPFVMDNGVELDI
SSSIGVVMYPDQADNMRDLFHFGDEAMYRAKKGGRNAVEVFAPLAQSDERSRENLQGRDA
QQLTGDEEH
>A0A239SHT8|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MSQNAVAVMPESNTLLEIVKAQTEIAKLGLDLGGVMDFVTERVQHLTQANGAVVELAEGD
DMVYRAASGVATNLLGMRLSRDGSLSGQCVKTGEILRCDDSETDPRVDREACRKVGLRSM
IVTPLKHLDTTVGVLKVFAPDPLAFPDADVRTLELMSELIAAAMFHAARFETSQLYLQAT
HDALTGLPNRALFYDRLRQAVHLALRSSSRLGILNIDMDGLKPINDRYGHRAGDAAIRAA
AERMNATARRSDTIARVGGDEFGMILCGIHSREDAEAHSQRLAQEVGAPFEFEGKPLELG
VSVGIAMLPDDGTDMTQLMDHADEAMYAIKRTRPGTRR
>A0A5V6HHH0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Goldcoast|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F7LHQ7|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MAHQNSEFRSIATLMLQRIIALSLVCLVGIGGFQVWLDRQKQEKQFFNTMSLIVETSSRA
IAYAVWDIDREVLHNHVQRLTEIEAVGFVRLTMNVTGEMITAGRTGIGKDVPSYQAVIYS
PDYKNQSLGTIEVWADRAYHRNLLWESQKHVIPGYLIFTVLMCFMVAWVMQHDLGIPLRQ
IADFVRNLKPEELNQPLELRRPDRQRADEIDMVMQGFQHLQTALDRHIKDLDGLVKERTA
ELSTMVDEVKRLSQLDALTGAYNRRAMELRLPLDIERCMRYGRPLSVIFTDIDRFKLIND
QHGHAVGDEVLKDVAKRLQEGLRANVDWMVRFGGEEFVIFMPETALRSATEIAERLADVV
RKTPWQMGDLVLPLTCSFGVTQYQPGDTMDSLLERADELLYKAKRDGRDCVRASLGSEAE
ISANYVN
>A0A1B2D0F6|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MPSFYAKQWRRLLSSFSPQIRCLVAEMAQAHNQALAEHFYSAMLEDEAAAGLLSHEQVHA
RLMGSMRQWIAQVLSAQPEDDLEPLVQHQVKIGEIHARVDVPVHLVLRGARRLKDGWHHL
LAQHHPEQQTLASQMVAAVIDHAMEAMSQGYAVSRDSNSRTKEAYRLFSVTQNLTTVREQ
RRAELLAWENQCLYLHALGAESQPLSNLASSNFGLWFRHKGADMFQGAPAAQSILDAIER
IDQELLPALMRAKGGEVAQPLLQLHEQVRHMAMNLEALFTQNSELDAGRDVLTQLLNRKF
LPVVLSKEVSYARKSAAAFSVLTIDIDFFKQINDQHGHEGGDMVLQQMAALLSHNIRGGD
YLFRLGGEEFLMVLVDTGSEGAQRVAEKLRKQVEQARFQLPRNQTQGVTISVGVATFDGH
PDYQRILRQSDAALYRAKTAGRNRVQVAELEG
>A0A8F7Q6X0|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MDTAFVWDQHFVTDLDSVDEQHHALVDLFNELSRGLFSKRSDREVVLADTYARLLAYTEH
HFQEEEALMQTFSVDSRHVESHRSMHQQFVEQVIMLWAQRTTMSDPATTLVGFLTSWLGL
HILGIDQSMARQIKSIQDGMLPADAYDKERGNHDNGTQALLKMIGKLYTALTSQNAQLAL
ANQTLEARVARRTKELEEANTRLKALSNTDALLGIANRAHFNERLEQTCAMARRSGRPVG
MVLIDVDYFKRYNDRYGHLQGDACLQAVAKAIQSGAHRETDLVARYGGEEFAVILPDTTM
EGAMAVAQRMVDAVQALGLEHESSPIAKVVTISAGVFSQVPTGAGAKLLVREADEALYRA
KSAGRNGVMGSAQQLPAHAQA
>A0A427V8W7|diguanylate cyclase|EC 2.7.7.65|Atlantibacter subterranea|TrEMBL
MSAKIQQHAWRARHPIKIVNFCFLVVFLCSTLLTWREIVVLQNGWTASQKNRIQSVAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAQFDQQRQSGAWQIRLDTQRGLPVN
GVSDDRVRQNPLLARDEQRLENELIAALEFGAILQLADPQQDRQRRTFYTSRAGFYLSST
PHAASDDIATRYHRLVTRPYFHSHTQRNNPDRGVRWTHAREANRQEDQVVTASLPLDYQN
QWYGVLAMDFSLGTMNDFLNQAMFRRENGEILLLDNQFQVIASSAEPVPAGSVFSDSERE
RLTREMAEHNEGGALIDTRYVSWAKLNFFDGVLIRVYSLKQSLSGEFGSILLVLGLLWAL
FSLMLLGSWYVIRRMVRNMFAMQETLQWRAWYDAQTHLFNRGTFLERARQIARRCQQQQM
PLCVIQLDLDHFKRINDTWGHQTGDKALSHAASILRQSLRGDDIAGRVGGEEFCIVLPGT
LLPEAAAIAERIRVRLNSKEILVRQNTTIRISASFGVSCAVQEGDYDFEHLQSIADRRLY
QAKQAGRNRVSSSDG
>B7LRF4|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)|TrEMBL
MGIMEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLS
NEQVERQLKSAMEKWIINVLSGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKK
LLYPVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFSDSSAAKEDENYRIFSLLEN
AEEEKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGH
ISRLIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGM
DVLTKLLNRRFLPTIFKREIAHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVS
QAFYDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIRSRVEKTKLKAANGDDIPLS
LSIGAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL
>A0A5Y2SBQ2|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYAASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVSRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGYFGS
ISIALTLLWGLFTAMLLISWGVIRHMVRNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAQRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVG
GEEFCIVLPDATKAQALQIAERIRQRINDKEMLVMKSTTLRISASMGISSAEEYGDYDFE
QLQLLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0Q0IQW9|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MDFFALTMVLLGLVGLALSLRPAYDICAYSQFSSKGWLALLMMIVLFVIGYFSYLSLLLQ
HQDRVNFIEVIVAGIFLAGGWFVFLVTNLSKQTIENLDDILQQKAHQASHDILTGLPNRQ
QFYQQLDSAIARKPDSFYCMMLDIDNFKMINNTFGHVEGDKVLQVVADRINQTVPSDGVI
ARIGGDQFALIVPDVEARNITVVAKEIEQALLVDIPCSGHMIVVGVSIGISKYPDNAQDR
KTLMKTADNAMYHAKEHDIAHHYYQADIQSSQYTSFAADPHGRRF
>A0A0Q0H858|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MMGLSMNKKKPIFDPKTFLLDNPNELISLDKWQKTVNLLAKVFHAPAGFLVQFTPDDGFQ
VTISSQQDSNPYAAGIVIEPEANIFCRRIVETGNPLYVPNAPIDPCWDTNPEVHNDGFTS
YLGVPVFWPDGHPFGTFCVMDYKQTEYEDSYLELIEQLKDILESDLALIDLYGQMQQLAI
TDPLSGINNRRGFETLSQQRIALAKRNQAKLGLCYLDVDNFKLINDQYGHKTGDDMIKHI
GTVLQNTVRQSDVIGRIGGDEFVALVMLEHESDLVAFKQRLEVGFCCAKRAKHLPEYSVS
IGSIEVDLHANFTDLLDKADQEMLKNKKRVA
>A0A653HYH1|diguanylate cyclase|EC 2.7.7.65|Moraxellaceae bacterium 17A|TrEMBL
MTQAALPSFKEQLQQTLKFFSFKPSLYINSPRVNDTNKFMLFIMLALVETFFHLVWYATV
LVITSPIDIFPFAHKFNQIFNRSLMINITYLGLAMVLFCGYSLWVITRIPEQSRLWREYQ
IFFVIIYLIYENLFIVWIGNNSALEGVMLISATGLGMVLLRWRLVWVSFVSCIVALFIFN
ISNSMNWWQLLPRLYPSLAARSHWLWGLSFSFLVTAKATVTLYCILQGMKVMSVQRRKIY
DLLEADALTNIANRRTIYSFLSYLWQRKSDWNTLSVIYIDLDKFKHINDEYGHDAGDATL
ICTANTLKNFLPTGTMFGRMGGEEFCIILPNTGIEQAADMAEQLRQAFEKQVVRYGIFDT
EIQFTASLGIASVYQNHGRDSERAIDNRGFIEYMREYMHSLPTMPALPPALERIIKCSDL
AMQQAKANGRNCVVKGQCYLLMTQSNQPS
>A0A2K9JZY4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MARTQALAQPSYEELASTLSAMPDLMFELDEEGRHWDARILRPELLVAPAEQLIGHTVTE
VMPEQAAKIVMRALQEAKVNGYSHGSHIHLSTPVGERWFEVSIARKIVTASDNHAETRFI
VLSRDINDRKLEYLEAEKLAYHDQLTELPNRHVLQHGLMEQLHAGQLFGSYSAILFLDLD
DFKKVNDLHGHHVGDQLLKAVAQRLSASVREDDVVIRWGGDEFVILITHLSPQQPQAESH
VVGICQQIINKVDKPYLFEGNKLSCRISIGVSLFNNVDIETGIQQADSAMYQAKQSDSVR
YAFHDKPIKDVGT
>A0A759HAA0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYTKQSGRNRICASDATQEREKK
>A0A6W0MVX9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGYNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8I1ZRE0|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp|TrEMBL
METRKRTFVIDDEEDILFILKEFFRNHGIEAFTYEMVPDMASEIREKKPNAVLLDIFLPG
ISGIEILKKIKEIDSNLPVIMMTGHLDEEKKIESLRSGAYAILAKPFKSYEEVYHITNNA
ANHYLETQRTIELTAEIEKRHEHERLNLLELDFLKKLQLMIGETEDPAFVIKNSFALLKN
FLNFQAFAALMLQGEDINIQIYPNVGSNQKLMECITMSLMNKAPERTKVEKQMSEMTIAG
KDTLSTGEDKYNFMTVDISARDRIYGYAGLYRVLPFHDDEKAIFNRFCSNIAMTLEKISL
FNEIRSLSIRDGLTGIYNHAFIVEALKDEVERSRRYGSLLSIALFDIDDFKKVNDTFGHL
AGDAVLQKLAELLKSSLRAIDIVGRYGGEEFLAILPETDGINGYIVAERFRERIEKESFT
NDEGKFNITISGGVAHFTQGMDVNKLIKIADDNLYAAKRGGKNRISYA
>W8UM50|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30684/NJST258_2|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A6L5BW98|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MVTKNLQDSSHPQWPEAAQTLMALMHAQGEVARLSEREQLFSSLLVSVNAVLWAFNWETR
QVLYVSPAYERIFGRSAGLLLADYNQWRDSIYPDDLDYAERSLAEVLVKGAVEDREYRII
AADGQVRWLSDKCFINRQAEPGQPVIIVGIAEDITEKKQMETELQRLATTDVLTQSSNRR
HFFECAHREFQQAKLQGAPLAFLLLDIDDFKVVNDSYGHPAGDTVLQHIAESGRAALRRG
DLFGRIGGEEFAAVFPGCAPDMAMQVAERLQREIQRLSFSHDEQTFGITVSQGLTSLTAE
DESLDSLFARADAAMYEAKRQGKNRIISA
>A0A5U7YWZ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMVLKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2H6IWT6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin10|TrEMBL
MPNEAKKTPMQKQSGARTGLKSRAAGKRRAGAEAEFLPAIRPSDLPPETRSAVSRLMAEL
DRLKEELSAARGRVIELENKADEDVLLPVLNRRGFDRELERTLAYVKRHGTDVSLIFIDL
DNFKSINDLHGHAAGDAALMHLTDILIANVRRSDIVARLGGDEFAVLLHRAGEEAASMKA
DQLSRALASSGLVYEGKEIAMSLTAGATRLRADDTNAAALGRADKLMYEAKMRRNDARRA
HSA
>A0A5Z0QYN9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLFHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U2F3M9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALY
>A0A0L6Z877|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MSVVNTVLLILTLFFALIALYQYKLIKDFNKSQELMEKIKEKLYQTSEKVLMTENEDEIY
SIVLNTAVDLIPNGTNGSILVMDEDENFHFKVVRGFHEDLHDLVLKKEEVYLNSVNKFKE
TAIIENPRKFDEVNTNAETINELRKRDALNIYCTISAPIYIDNKLIGLLNVDSSKPECRF
TKKELNLMNLIKSELQIALKNAFAQNKLKYLANFDELTGVMNRRRFNKEFSIEMEKIKQE
GKEFSLVMIDVDEFKAINDTYGHNFGDKVLKCFSSLIKSYISETDIIARLSGDEFVILFR
NCIGDMAKERMDKITDIISSKKINGINISFSHGICEVRDFDNITAEEAIVLADTKMYSCK
RSKRI
>A0A0L6ZB50|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MSNFEFDKHKRIYEILSIVKLAALLFSGVAFFRSYFDNRFVLSNTKSFYTSLFCIILVLL
LSLVYIVWTFPTDKKNILKDDKYIQFAEGFIFTVIFFTAILISGGYESSYKFLFLFIIIT
STIQSGMKQGIIIACISSVIILAIDILGVHSGEVNSYFENDLILVGVFILTAWPLGFYVK
IEGEHIEELKRLVNEDGLTGLYNHRFFYEVLNKKILSCEVERKPVSMILMDIDYFKYYND
LYGHQKGDEVLKSIGLILKSSVRKTDIVARYGGEEFAIVLTNTIEEDAIKIAENIRSKIE
ETYFEGEENQPNGKITVSIGVSVYPDKAKNDVELIKSADDALYRAKFFNKNRVETYTSIL
DELKKDIEESDIDLVTSIKTLISVINAKDRYTYGHVERVVAYGRILADKLGLSNDDKKKL
IYGAYMHDIGKINISKEVLNKKMPLTNEEWELLKQHPQNGVAIIKPVKSLRDISSLILHH
HERYDGKGYPGNLKGEEIPFLARVLTVVDSFDAMTSNRPYNKRKTYEEAIEELKKCSGTQ
FDPSITNSFIEVITKEEYKILR
>A0A840AVW4|diguanylate cyclase|EC 2.7.7.65|Kaistia hirudinis|TrEMBL
MTARVLVVDDLVANLKLLEARLSAEYFDVVTATNGAEALEICASGQCDIVLLDVMMPGLD
GLEVCRRIKRNPLTAHLPVIIITALDQPSDRLRGLEAGADDFLTKPINELALITRVKSLV
RLKALTDQLILRASATADLGINDPFDGAIVSGDGGRILLVDDSASSRARIVDALRVQHQV
DIEADPHEAHFRLAEVNYDLVIVSLNLTGFDGLRLCSQIRSIERTRMLPVLAIVNPDENQ
RLERALELGINDYLIAPVDRDELQARVRTQIRRHRFTERLRETLHATMEMAITDGLTGLH
NRRYFERHLAAMFEQATVRRKPLSVLMLDVDFFKSVNDTYGHDAGDDVLREFSRRVRRTV
RNVDLVCRLGGEEFVVVMPDTDTPIATLVGERIRQRICGQPFLIEGGEQSISITVSIGLA
RRQDGGDSPEAVLRRADEALYQAKREGRNRIRSAVA
>A0A7S6VV64|diguanylate cyclase|EC 2.7.7.65|Acinetobacter piscicola|TrEMBL
MNEASIVDLSRQWQWICDEFSNTDLTYALQFIQDNSFVLVSEFYKKMMEEKTASEFLSDE
IVQSRLKSSLNNWLLESFEVPFQKNFYEMVQKQLKVGEVHARIGIPSWLIIRGIRQIEKK
VFCLLNKPQQNLLSIASYIVQVLGFTSEIMSRTYEAKAEINNDMKHTYRLFSAMQDVAVQ
KDKQRGSLLDWENELMFKVFSDQTNFTHTSLSKSEFGLWFIHKAAYAFSSSDQVKEIISG
IKKVDVLNQKIISCADKTFAIQLIQEIRNQDREILLLVDQLFQVSEYIGSGNDSLTQLLN
RRYLNTIVSRETLYARKHKTHLSLLAIDVDHFKRINDQYGHATGDTALQLLAEVILEHTR
GSDYAFRVGGEEFLLLQVATDLNMAEQIAEKIRQRIQTSEILSSTGVAVQFTVSIGVVSY
DGHPDYQRFLESADTALYAAKNNGRNLVYIA
>A0A811GZG7|diguanylate cyclase|EC 2.7.7.65|Achromobacter mucicolens|TrEMBL
MLDPILAELSTTLPAAKSVEQLTRPLLDMLGAVTGLESTYLTSVDLKAELQRVRYARNVG
HLQIPEGLSVPWDDTLCKRALDEGRMSTSNVAQCWPDSDAARQLGIQTYVSTPVRADDGA
LYGTLCAASARRHEISPEAEAVLKLFSSVIASFIEREMLVEQLHAANVQLMSYALTDTLT
GLPNRRALYEALDRLLARAVREHGSVLVGVIDLDGFKSINDTYGHQAGDTFLQEVSRRMA
AALRGSDMLGRVGGDEFVLIGPGPALIRKRPDAGGVAQQAEAEEAARAMEERILAATMGR
YPLGETTVAYEGASAGVVALDPAGLDAEAAVRLADARMYEIKQARRAARTIH
>A0A0L6CUA5|diguanylate cyclase|EC 2.7.7.65|Roseovarius tolerans|TrEMBL
MSRVSHEAFLAVLDRICPMHAVLAPTGHIVQAGPTLAKVIMPRAVTGTRFLDLFELVRPA
RVHDMTGLLALDGARLRLRLRAGPRHAFKGVLAPLDMAGERGALVNLSFGISVIEAVRDF
GLTGADFAATDLATEMLYMLEAKSAAMEESRKLNLRLEGARIAAQEQAFTDTLTGLKNRR
ALDHILDRMVQGGEDFALMHLDLDYFKRVNDTHGHAAGDHVLQVVARRMLSLIRPSDVIA
RVGGDEFILLFVGSNARDWLADVAHRLIRRLEEPVEHDGRICRISASIGATLRSLYDHAD
IARMLADSDQALYAAKEAGRGCYVIHPPGPETRTTLRDVG
>A0A2S0XRM2|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MKIVLLKSGFVTLLCIAVTMALVLTVIPLTNGTVDTAAYLLPVLCPVLIAFPFSFHTFWQ
REKLKVAHAELTRAHAQLAAAHKRLSEKASRDEMTGMLNRENFFAALDGSRRKTDRGALL
IIDADHFKQINDSFGHLTGDQALLQIAAAITRGVRSGDILGRIGGEEFGAFLVGATKDEA
KLVAERIRSEVEALRFQPNDERSVPLTVSIGGTTCESEANVSELMKSADKRLYEAKRRGR
NRAIFDTGVPEAA
>A0A2S0XF16|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MSGAGFILTINVFVAGLLAAAFMAISIYDAKRVSARWFALCYLTGLLYIGTEFSIPWFEN
TRPIVTANFAAFLATLIIMNVGLARRYEVAPPWRTMLVFLVLATAAVYFTQGLPRDSLLR
MMTFQTPYAAVQAMGAAIVLRSRDKLSQFDYALTGVLLTSALQFFSKPYLALAVGSGSDP
HQYLQSTYAMISQALGTVFALSIALMLLVILVRDILADATQKSETDALSGLLNRGGFQRQ
AAIALREAERQGLPVTLVISDLDHFKSINDTYGHLSGDRVIETFARFIHESKVGHHIAGR
IGGEEFAIILPGTHLAAARLFAEGARSAFSALPIEGLPSNQRFTASFGVAELVAGEFIDQ
LMRRADAALYEAKKDGRDCVRVAPGSVVEMQAETNVVPFGSKS
>A0A290HT32|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MEMNNNNHIAEMVFQLAEETFAKLKSLNIPPYPKYYHDTFVETLQKSGDTELMDLTKKHS
YLFSNAQQEEMVSETCFGLMKKGLEEFVKTNDNLKFISDETSINIDNIKKDYESVDTHQV
LQAFDNFQGKILHELQAADETIAKLKLEVERLERESNIDPLTKAHNRRVLVKDLEELLSV
GRDRDMDMHLVMFDADDFKQINDSFGHIAGDKTLIFLSKLIQNSLRRGTRIYRYGGEEFV
VILNRTSFDEATKIVDRIIKETSDSKLLYKNHDIHLTLSAGICSHKRTMSADELLDTADK
ALYEAKKSGKNCFRSAH
>H1WBC0|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MMGSISEQTLKADILVVDDQPENLHLLSSLLRQVGYNVRQSLNAEMALTSVQAKLPDLIL
LDVRIPGMSGYELCRHLKNSENTSKVPIIFLSALNDIDSIMAGFQVGGVDYITKPFHNSE
VLIRVNTQLRLYQLQKQLELQNQSLQEQIRLSQIYLHDRQVAEARRKLLEKAIAATQNGV
VITDPNQPDNPIIYVNAGWERLTGYAANEVIGSNCRFLQVNQRDQPALDDIRRAIAEAEE
CRVILKNYRRDGTIFWNELFISPVRNEPGELTNFIGIQTDVTERKKSEEALERSRIALKK
TNQELQRLALDDDLTQVANRRRFNEYLAYNWHRCAREQEPIALILCDVDYFQPYNDTFGH
QAGDDCLHKIARAISGAIQPFSRFGGSLWWRRICAIILPNTPINGAMKVAERIRKQVENL
RIPHPSSKSSNYVTVSLGVACQIAHSELCVDS
>A0A0F0C2Z9|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MRQSKYTDPGRMTKKQLEAENSRLQYIADRDWLTGLYNRGAMECRVDEYLKKKLPGTMIV
LDLDHFKQVNDRYGHIIGDELLCSVATILNKMSGRQSLVGRVGGDEFVIFMPRLMSAKDM
EELFERIKSRFQEIRLKNSILIKLSITIAGADSLGKQRYKNIFDCADQKIMEMKRQRNTG
TPRTKSGTAPGSINLDMDLIAGEIEEKDIIPGAYCQDYETFKQVYRLTERRLARERRSVY
IILFTLTDQNNEFLSLDIRDREMDLLGKELQNSLRMGDIYTQYSSCQYLVMVSGVSGEDT
EKIARRVIKIYYETRRDTVNNLVLHHSYPLKPAEPRKRASTLSGTHL
>A0A6F8ZDE4|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MAKDLAGETWPWEHLLAAWRALGEEAADEAAFLARVLAVLVDGRRVRAAWVEAAGSGGVM
AAAGEPLPVAGADVRSWPVGGPEGATPWRLQMAFAEAGVPDAGLAGFYGEWAQALGRALA
RREHERRRRRLEALYAALAALGEWFADHCERCRAPVPHPLLDQLTRTLAGVGFPSVSLRV
PQGARLVPVATAGAAGPLVARLPLGTGPGGCSAPVRAWSTGATAVSSDWTQEPLLRCPAL
APWRDRLAAAGVGGLIAVPVIVEGEHWGLLCVCTGEGAGLSAEEITLVERAARFLGLALE
WARSQETLARAHERTRRAERLYRAMLHGSALPLRRQGERALLRRICRDLVSSRIFTAAWV
GRPGEDGRFRYLAAAGAGSQALQQLRITVRDEATGGALASRAWRSGRIVYNNRHRADPAL
APWADFLARYRWESAAAVPIRRGGIIWGVLAVAAARPDVMDRTTLSFLSRVAELAGNALD
QADLEARLNRELEHQAWLATHDPLTGLGNRALLSQELPRALARSLRQGTSLALGLLDLDG
FKAVNDRLGHAGGDRLLQVVAQRLQAAVRASDLVVRLGGDEFVVLWEGITGPDDLPELVA
RLETGVGQPVVIGADRVQIGFSLGATCFPADPEDGDALLRHADWALYRAKAAKGRLGPRW
RLYGRDTGTWEGEAGKA
>A0A1S8LEM3|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MLYEKYEKLKNEFSTYQNFAEAQIQRMNGKNTELEKKLDILTNIIEVSKYINSNISADNL
IPMINDMIIGILGVTYSTIYLVEDNEKLIVKASNVMENYNVIVNPAFSTFSDNRPVVINS
KKPLFKEFKNKLEVHSIIGVPITLRDNFRGYIIVEHTLYDFFSHGHIKFISSIANQIAIA
IENSFLYNKVKESSIKDPLLGIYNRKHFFDMIEEKVAKDLRKSFAIVMIDIDHFKNFNDS
YGHQFGDEVLIQTAKVLENNISNNDEVARYGGEEIVIYLDNAENTEEVFKLVDEIRFKLS
NNLVKHGGIEKSVTASFGISYYPQNGESVEKVMSVADAMLYEAKDTGRNKVVSSL
>V6F668|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MENRSPSLREKVKQLRRTFVDKLPGTLAEARRLCDLLVRVPSDDSTLDDLYRTFHSIKGT
AASFGLLEISAEGAGGEQLVLQLQGLEGGSRGQQLPALLPGFQQRLERLEELWKLARQAD
ESNSSPESPSFDLGKEGAKAASKKLFICDDDEAQAEILAAQLSCFGYGVTIFTSPDSMRA
ALLVAPPDAVIMDIVFPGGVNGTDVVANLHREMRAPPPVVFVSSRRDFEPRLRAVQAGGE
AYFPKPVKAIELVEILDSLTLGQEPEPFRVLVVDDEPEVAAYHSFILEQVGMTTRLLHEP
ATILDVLTEFKPDLVLMDMYMPTCTGRDLSRLIRQVPEFISLPIVFLSSETNKVKQVSAL
RVGAEGFLTKPIQPEDLISAVAIRAERMRTLRSLMVRDSLTGLFNHTFMSQFLETSLASA
RRDDGMLCFVMIDVDHFKQVNDTYGHPAGDQVLVALARLLQQRLRNSDMVGRYGGEEFAV
ILQDIGTDEARRIVDDLRADFAKVRFTAGDGDFSCTFSAGIAGYPGKAQADLLLESADQA
LYVAKKSGRNQVQVAP
>A0A6F8ZDA1|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MALLPPLMLTAMARVGGFPLPWGLWPTVTVAQSYWLDWPLYAAATVAAMAAWAVSGGSAL
PGALALGVVAALAAWSPIRRRAARVGLLLASGWGIAAAAGWPGAGTRLAPGPALGEELLA
GALLAGYVLSHRERTQALSAAVEAVARDHLTGALTPEGLETWLESWARPPRGLVAIVDLN
DFKAVNDTYGHPVGDQLLSALARRLRQGLRNGDVVARVGGDEIACWCPGAEEEGAAQLAE
RLYHAVIADPVSTSAGPIRLDACPGLGGGSPGARNRRPCRAGAAAGQAAGGAAGSGPGGP
AGTGKPARARRTPLADGCGAAAVERLGGAGGAGGP
>A0A7W5KH44|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK049|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGHEALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGMGDLMRAAEGRGDEAGQVLLVDGRANSQERIVRALKPIAD
VLALSDPQAALFEAAENAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGTD
DMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEVAAAVAERLRAAVESAPFMLKRSSEALAVTASFGI
ASRFGAVLTPDQLMKQADLALYQAKNTGRNRVVAAAA
>W6M2Z0|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MQLALSADLPEREFKHRLASGEVRNVQVYNGPVKGGGLSFLCWVVIDITERKQAERQLRQ
SEEKFTKIFQTTPNVVVISRMTDAVLLEVNPGFEAVTGYSRMEAIGHSTLELGLWAEPAD
RERMVADLHLYGQVLYQLFNFRRKDGTVRIGQMSVRPITLNDESCVLFVMQDVTESQQSE
RELRASEERYRLLFERSHDAIFVIDRQSGRYLAANRAAEELTGRTAADLVQLTVADVVTT
EPSQRLLGNEEMPERLPLGEVRYRRPAGGSRTALLSLVPVNDAIMFGIAQDITEIKVARQ
RIEHLAYYDVLTGLPNRALLAQRAEWALALAMRHGQELAVLFLDVDHFKEVNDALGHSEG
DALLAEVAVRLRALVRAADMVCRIGGDEFVLLLPDTAQQGALQVADKVLAAFREPYKVTG
HVLNVSVSIGIALYPRDGADFNDLLKNADTALYRVKQQGRNACLSYDREMNAATLERLMV
ERDLRQAIGAGQLRAYYQPKVRLSDRTVIGAEALVRWQHPERGLVPPGQFIPVAETSDLI
VELGDWMLEEVCRQIADWQARGWVVPTVSVNLAARHFRLPKLVERVGSLLQAYGLAPRLL
ELEITESTLLEVSSQTTETLRALEQLGVGLALDDFGTGYSSLSYLKRLPLTALKIDQSFV
RDLVADSDDRTLAATIVTLGHYMDLVVVAEGVETEEQRSILFEQGCDLAQGYLFGRPVPA
SEFIGWLT
>A0A1S1HE19|diguanylate cyclase|EC 2.7.7.65|Sphingomonas haloaromaticamans|TrEMBL
MSGPDPFADIVPPNRSEAMFNGAFHSAVIGMALVGLDGRLIRVNPSFADMLGYPAGELEG
QRFQAVTHPDDLAADTEQFEAVLRGDIDHYRLEKRYLRKDGKVAHGMLSVSVVRDAGGHA
ELFVSQIEDIGARKLAERAAREEAERLALAFEVMEGGPWQYDIAGGVFTMSSYLTRFVCG
DGHGGIDADDFQARIHPDDRPAASFMALLANETDRAVAHFRIRVHDDEYRWVRSTAKLLR
DGAGQPESIVGITIDINEERSRQARLQMEAESDPLTGLLNRRGFDRRAAAGWGGLVLIDL
DHFKAVNDGHGHAVGDAVLCEAARRIRATVRAGDIVARLGGDEFAVLLVEDEGGDHAALA
ERLLAALQAPYLVDGARIAASASIGVAPRNYGGEAAAGLLVRADAALYEAKRGGRAGWRI
AA
>A0A6V8LMQ0|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MAARRSKPAKGDAPAVCARALLKGEASREELARGLAALADAHGELVRRFEKTLRISDTYQ
LQIREMASNMERMAAKVRHLQELTLPICVQCRKIRLDDDYWRQIETFLRDNVDTLFAQAL
CPECVQAGHDALRAGSESRPSFGTPAPVGAKPPARLTPAEEETVREMRALAAKAAASDPE
QGERLERFAQLHAKLARRFAKTVSISDSYQSQLKDLSLRLELLARTDVLTGLVNRWEMTH
RLDVEYARMMRRGVPFSIALGDLDTFKRINDSRGHAAGDHVLRSVAGAMRANLRAEDLCA
RWGGEEFMLLFSDTPQEDALAAAGKILDVVRGLEPEWEGSKIKVTISFGVVQLRPGMSLD
TAFRLADDALYEAKRQGRDRVVAASGESL
>A0A0N8NSR5|diguanylate cyclase|EC 2.7.7.65|Oxobacter pfennigii|TrEMBL
MRWCFYKSAPAIISASGFIFSLFIYMAVKYLPPDADLLLWATVIFTQTLSGLMFGLLIKK
LHDRSNSDSLTGLKNRRYFYNRLAHEMGRLKKVKSSVSLAVIDVDNFKNINDTYGHVEGD
RVLAELASIFKTHARAKDIVVRWGGEEFAIILPDTDCEGAKAYAERIRSVVENHSFPCKV
TICIGITCTEIDMDMDKFVAMADQALYKAKEKKNRVVSMKGQLLLK
>A0A0P8WEW4|diguanylate cyclase|EC 2.7.7.65|Oxobacter pfennigii|TrEMBL
MKLNYLFSSILIISTIIMMGIWIYSWRRRKGTMALNSTAVMLAASLYSLGYAFEIVSTDI
EQIQFWLKIEHLGSIFLPIFWLIMTMQYLGYTKYMNKGIYVLLFTIPVISLIFYYVNGWH
HLFYTDIFISEHLPFPVVMVERGVWGWICIIYSYLAIAVGVALYIIMFKRSAPLIKKQVL
FMLFAALAPLILNMIYVFGGFAHHIDLSPLGFMISGLFYCMIILKFNLLRLTPIAYEKVF
KSMKDGVIVLDDENNVINYNNSAKNIIIELNYNSSIGEKYSYLFKRYPEIIDILERKAET
DNIQASIVNEKGIKHYNVSLSFIKNRSLNNLGKIITIRDVTEQVDMMQKLDMLASTDELT
KLYNRRQFYQKCEIEIERAKRYNRPLTIAIFDIDHFKQINDTYGHHVGDLALKNIADICK
KSVRTSDIIARYGGEEFALLLPETNFKDALRTVERLRVAISKEDLEVDENKINVTASFGI
CSLDLESNQSLSDLIIKADRALYDAKKLGRNKTVSYK
>A0A8F8ZMQ2|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTGNAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASTLRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A2D0APQ1|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. VS1|TrEMBL
MPISPLSSRRMTPALRVHLCFLAVFLFSLFLTVHEALELKNNYQQRQRAQLSEIQRSLDS
RFQESLDELNYYQRMLSYALTHPLDADYGQHALQRFQQLRHQPVWQLQIANLRSMPINGV
SDEWLQRDALLQRDDTYLLPELRAALEFSFIMQFSDEAQDFHSRFWYTSRAGYYISSRPP
RDAQELAQSYATMTQRPYFRDQQPGRALQTRWHWTEAYQGEFNEGLMLTVSAPVIAHQHW
YGVLSMDFTQQRINALLHQSRHSVLQGKLVLEDRALNEITRLPAPHDVALTPAQRGQLIQ
AIHQQPAGTLWLGSQLASWVKLKNVDAWLINVQSLRQGLSQELGRVALFLLGMWLLFVLL
LALAHQVIFRLVRRLEDLSARLAWRANYDGLTHLLNRSAFFDQFIALARRCEQQQQPLAV
IQLDIDHFKKVNDSWGHHAGDQALMRVAGVIKHTLRPYDVAGRIGGEEFCIVLPHTTLAE
AQGVAERIRSRLAAKTILVNASTTFSVTLSAGVSCSTEQGSYHAESLQAVADRRLYLAKS
GGRNRVCAAG
>A0A376FAJ1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MAGEPRVRFYAGFPLRLRDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISA
ATTDELTGLFNRRGFNQLVRFTLSVARRRAEQLTLGWLDLDRFKEINDRFGHEEGIRR
>A0A376F860|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MLGNTSSDAAYQVAERIRLNLSSFDNSSSGGQLPEPITISMGVFTATSAAVAAETCVENA
DKAMYEAKETGRNRVVVFK
>A0A445N8P1|diguanylate cyclase|EC 2.7.7.65|Streptomyces netropsis|TrEMBL
MNALLTASAAAGPLAAGWSLHTLLLRRRIERARRDPLTGLPGRDAFTTTARRRLRAPGGV
VVLVDLDGFKQVNDTHGHAAGDEVLATTAKRLAAWAKARGGCAGRLGGDEFAATVTCPAP
SDLPFELDALYDALTTPVVFRGAEPEVGASIGAFAVAGLPDPVLALALRRADEAMYAAKR
SGGGWRIAEGPIPAMTSTNGRRTGRPGTTPTCTGGTQ
>D8ABH4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain MS 21-1)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGTPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1M4N7B0|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. N3C|TrEMBL
MYKDKFEVIEFEKWNKKILNVYWIIAIISTITEIIIYFLTKDQILSNKFDYILVYIITPS
VNNVILLSISEIINKLIKNKHKEAAKYLIIISGTFMAFNLICIHYSVSMMYLLFILPIIL
SVYYGSHKIAAFAFFLNMILYILFITFYLPNIPSGEIYHDLTDVITTISAMISTALIVRS
LIIRTGEIINNFLSTYERERDLTLKNFVMEYNSKIEPFTGLYNHKTFYEYLKSLIEQSEY
YNFPLTLAVMDIDNFKKVNDTYGHSFGDEVIKALADIIKENTGTDDYAARYGGEEFAIIF
PDKDKKKAFEIVEAIRKQFNEKVFQGKENERFSISAGIRGHYKGLSMEDFFTQADAALYV
SKSSGKNKTSIYEDMES
>A0A8F6RGK1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIPLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y9I4L3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWELLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379V1A4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFLPVAAVLVTQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGM
WIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSS
LEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNE
FDHSRRHHREATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGD
EFAVIMCGTPADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKS
ADMALYKAKNAGRNRTEVAA
>A0A5Z0E802|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARSIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A822WI09|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRVDNGYAILRLYLCAVRRKMKNITLAEKLIMLSGAVLFALMIAVNSFCVNDNPGFRVPM
TTYLIVMIALFFLDTIIFIFIQMLYASDRTRFSLFILSLAFLSGLVYFIETIIVIQLPEH
AGFTQAAKTNDTAVFHFFRQLSFIVLLALAVRVEKITIRSTLRFRNKISMTLALMMSLVM
FPMLAHYLSSYHPAWTLTIAAYEDEHHHPVWDIRYVNVLILLWSALLCYMISVTRLASGI
WNSIIVVCLSAIVYNFFLLLLDTYNLSLWYISRAVEVLSKLFVICTLMFHVFNLLKIFGD
RVDRDPLTQIYNRKYFYEALPRIRSLRTEKGASIMMLDIDNFKSINDNWGHLVGDRVILA
VVDIIKDSIRDNDIFARLGGEEFGLLLPDTDSRQAIAVAERIRQNVQQRTGPGYHYALPV
KVTLSIGVCSAIQNNVNSNDIMRDVDEALYEAKHNGKNRIVTRQAECS
>A0A8F6MQ16|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVALTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPLPVAQPIIHNGNVIGEIRLTARDNLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVAEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAHEVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A8F8GSC7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGALHDAVKRFAHLRTSPTWQIAVDK
RRTLPINGVSDAFVDKTTLLNRDDEYLDNELSAALEVGYLLRLASSSSRNEERVIYVSRA
GFFLETDMPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKILA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYLFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A8F8GW33|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKESDVLKAYQAKEGELKNIEHKVGQLKDTGATGEELALLYEGLKIVDGLQD
EQQAAIASVARGEEQQAIALLFGKIYELETERAQSKIDHFRMLLDKRIIADVQAATKTSK
TLRTASEVMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPNFNQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVIAVAELFAP
NIAPGVAGRLYILDRNPWEMRCAAEWLSPQGEKNAFHPDQCWAIRRGQSHPPVNGEPDIG
CQHLPESQKDSSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQITQAMRNNEPVSCMMIDIDHFKSINDRFGHEA
GDHVIKSVATIVQRAVHDAGLAFRFGGEEFLVLLTGADEEAAHACATEIYNGVHTLSLRY
GLAEIGPVDVSIGIASYPQHAQSDDLLRAADVALYRAKELGRSRIVSFSMLEAG
>A0A1X7A8A9|diguanylate cyclase|EC 2.7.7.65|Limimaricola soesokkakensis|TrEMBL
MAMLLNSLSLDGDAEIRDLCSALGSCAGVPARLRLLPAPSAGQAGWRDGAAASHVIFPVD
TDWMGELTFDMAGETELSEAGRKAVQALLPLAGSLLSAAQERRRLKASLDWLRDHNMALR
RRTRHDPLTGLLNGRSFHAMARLMSRQPLQKRASALMLIDADDFKGVNDRFGHPAGDRYL
KALARSLRDLCRPEDPVGRIGGDEFALFLHDVPADRDWREVMTDRLRARLRQEVHLAVGP
DCQASVSVGIAIFETPRGDYATLLKEADTALYAAKAESRASG
>A0A2J0R6R4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A793GI31|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSMLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8G9C9T6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVLRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMSSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376KWJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTFLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVT
QENTLNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A5B9AIB2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYLLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A3S4K004|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLIGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A376P8G4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQPLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDG
>A0A811VZL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPISIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376L9C3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRYISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A400U3I7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCINMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLDNSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A826SK98|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGGEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLHNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A826TUV4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKIEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPVLSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A8H2HB13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTRRNRCMFIDEQNVINRV
>A0A826TIZ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNDGRGRV
TVYEPQQATAHSERAVMPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLKLQNDE
GNVIDELVFRHGFSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEVIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A6G4LPU3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8G8YG98|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISRYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A143DU20|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRVFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A376LP25|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPRIGIPVEIVEMGFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTF
SDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADF
GLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVS
QIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKF
KEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERI
RSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWK
ASL
>A0A826XDF7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFSTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGALVVLLTPGNDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSTLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8G8XWP5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHVSNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A826UJF8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVILLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTALQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGRV
TIYEPQQTAKHSEQAMMSLDEQWRMIKENQLMMIAHGVASPRIPATRNLWLISLKLWSSE
GETIDELAFRRSFSDPALNLALDRRIIHEFFQQTAKTVASKGLSIALPLSVAGLSSAPLV
DKLLEQLESSSLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSGMGVD
LIYGDVIADAQPLDLLINSSYFAIN
>A0A1Y2XJ47|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPSGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A6C8RXS8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1X7BMH3|diguanylate cyclase|EC 2.7.7.65|Roseovarius aestuarii|TrEMBL
MNTDAGTGRSWFRPAFLAAFLLASLGASFVVVRHAPEPIVCWLLETEFRSLAEKWRTRTL
SQLENSTRTFENQILTDTDIQLLSMIPKVSDYYRFTFIDTEGNTFWSSHPDDIGKSDMSH
ETGQALARGEVVLLHLHVNHGENEEMDGHGVHLYDGDHRTVYEIYVPVMDGDTRLGAVKF
HTDVSSIHDIFLDRVSRWISVAVGIILSLMLIAIGLIIRSSRIQLKNLENRTREEREMMQ
RQMRLAREVRLLGELNEWLQSSRSLSELFDMVARFMLHILPESEGSLYVYSNSRDVLDGS
ASWNGGSHRDHIHPEACWGLRRGRSYHYGQSEVDFACEHTEPNDGRPYFCFPILALGETV
GLMHLKRHADATEEAFEDSRRLAQMCAEQISMAIANVRMRDQLEDRSIRDPLTGLFNRRH
MLDSMRRLIAQADGNGSALHTVYIDVDHFKKFNDNHGHDAGDMVLRAVGDLLIKQCDGDE
VACRMGGEEFMLLLPNLTLDNLKERIETLRREVTAISVRYGEKALPKITISAGIASYPAH
GRMPQDLLRVADEALYKAKDNGRNQVVVAELSEPTEATPQNPPPKKPHSLGAE
>A0A7H9N896|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLDNSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A811VVV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYFYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2X1NKD3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMILIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8G9NY32|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTWTTINIVEAVVGAVLLRKLLPWYNPLQNLADWLRLALGSAIIPPLLGGVLVVLLTPGD
DPLRAFLIWVLSESIGALALVPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSML
YLPWPFTFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPW
LPFLLILLPANIMTMVMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKA
LCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWA
LLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPN
IFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRIAVK
DGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVC
IDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQ
DVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHL
ANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSM
LRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITL
IDDNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQAAAHSERAAISLDEQWRMIKENQ
LMMIAHGIASPRLPEASNLWLISLKLWSCESEIIDEQTFRRSFSDPALSHALDQRVCHDF
FQQAAKAVASKGLSIALPLSVAGLSSATLVNELLEQLENSPLPARLLHLIIPAEAIFDHA
ESVQKLRLAGCRIVFSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQ
GHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIANAQPLDLLVNSSYFAIN
>A0A8H0NK03|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLHDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A3P5DUZ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKH
>A0A8H9E8Y4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSNNYWYGVLGMNIPVRTMQQFLQNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTHLYNRGALFEKARQLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRALDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSSTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A485JGV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKSQRHLGASGWRSGDKNSGEYHWEKHTAR
>A0A376KNL4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKWKSGSFVYRPKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGD
NFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQIC
SALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A789M6Z3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLSLYLMLLDIDRFIDRFKLVNDTY
GHLTGDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNH
AIAHPGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A377MYX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETPLSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKNKVFMRAFF
>A0A377YWF6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A377MZV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHK
PLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGL
LNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFIHINDLYGHSKGDEVLCALARTLESC
ARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEG
NESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376ZZK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEE
ACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGR
NRCMFIDEQNVINRV
>A0A377D5X6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPKNSWSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEM
GFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYR
IFSLLENAGRRKRTANSLITFMGNRYYL
>A0A7H9Q6Y1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPTTLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHRLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A6D0G1E0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
TNYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376KV44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKNPL
SGNLLFGLFCRRKTSGLPFLD
>A0A6C8S811|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1V5QQD8|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MLPLFPELEAISSCRDRSALNQILLRAFAHLLGEDADVALFRRDQGETGLTQCVGPTVMS
AAFGAWDGLLRASLVPNLLKSEVQDGRAYGVIPLHSSEVSSAKTLIAFAADEKLLRRHED
NLLCVARVYGNHVKLLDYSELDSLTRLLNRKTFEETFERLLQAGNTEELDEDMVERRSNE
DGVAWLCVIDIDHFKRINDNFGHLFGDEVLLRMGDLMRKSFRSGDRLFRFGGEEFVVILN
ADNESLAQRGFDRFRQAVESNEFPQVGKETCSIGFTRVSDSDIPTDVVGRADEALYYAKE
NGRNQVRCYEALLAEGMVSGPAVVEAPVADFDIDALFD
>A0A2X6RSW3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGELLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A6D0IHK5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQNLTFSQLRIGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAAL
>A0A5F0Q4D7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLIRLYNRDALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAHDVAGRVGGEE
FCVILPGASLTQAAEVAECIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376X3Q8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSEFDGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGW
VSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDID
HFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAML
RVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVA
A
>A0A376MWX3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPIARARLLMQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALS
CRLVLRKLTEAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDP
SRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLKFVH
KLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQF
YHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDL
VFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDE
LFKRVDDALYRAKNDGRNRVLAA
>A0A376HXH3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAVHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A6G4C029|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDSHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376U3P0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEFTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A376VJG0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLI
DPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNL
FINWRMVRLVMCRPMPGRLKFMATSSCYVLCMILLSKNGWRSSWNMLPTMTR
>A0A1V5QUL5|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MNVPGTDPNPYRYSKRNFSLVFFLGGLAMLSFVPRNWRSGDVLVAVLIAVLVAVIWGLAA
WALLRQRNGSAVILWVTVLCNVGCLVALFHLHRVGVYWFFPLLLATSFVLPWRWSIPVNV
VNVAFALFFAFGWMPLEQYYRLIATLSISMLFSSLFSINIERQGGLLMSLVIHDPLTGAF
NRRYFEQKLSESLRYRKREGMVSCLVLIDIDHLKPINDIHGHAMGDRVLVAFSSFISGQL
RPLDRFFRLGGEEFAILLPDTTATQAVQLAERFRRYLADGSLDGILPAFTISAGVAESPE
QGTEGEWLAQCDQALYAAKESGRNRVVVAENTSVNESPGIEAL
>A0A379KVP9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MNQETRPAPPGFSEQQLHTLFELVSDGIWDWNANTGYVYRNPGWYAMLGYANHSKANSVF
TWESVIHPEDYPRVMAHFEAYIEQRTERYLIEYRCRCQDGSYLWIEDTGYIIDRNADGSV
ARMLGAHRNIDAGKRLVAQLQQKNQSLESLVAERTRELSWVNQQLQRQLDENRELAERDA
LTRVASRYRLEKELQLECQRAQRFRQPLSLIAMDMDDFKPINDRYGHAQGDRALVQVAEN
LRSCLRDFDLLARWGGDEFIIVLPQTALSEALDVATRLRQAVQQLEPVGDCQLTMSYGVV
QRRGGEDQVELLARADQALYRAKGNGKNVIAE
>A0A5E4YR99|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MKTTISRTEPGNRVAATTILVACAALTLAGFFARAIQGEVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTHAPFWLWFMAEA
SFAAYVMLSVHSYTRTRSDPHIRPGYKEAAWYGATVLVIWATVSLALIGTGRPLIVAPPV
GGISVETLALYGLFVAYVALWWRVATVTRLSHKLFLLVWVVVTISLCQLLLSLTAPNDAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFVDPLTHIYNRRYFDNR
IRLVADRVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDIVLQRIASTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQQAALRVADRIRESVKRASTELLPEKARDRGEAITISVGIATWQP
GEPLVISAMLERADRALYQAKHKGRDQSVLGQLAA
>A0A1S7LF03|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MSEEREAGRILIVDDMVTNIKILKQAIDPKHQVFFATNGTDALQLSLEKGPDLILLDVAM
PDLDGFEVCKRLKADPVTADIPVIFVTSMEAEEDELKGLRSGAVDFITKPVRSAVVAQRV
DIHIKLRLLQRKLEALSYHDGLTGVANRRRFNELFKTEWARSIRSPAPISLIMVDVDHFK
QFNDHYGHQAGDDCLRTVAHAMEQSLKRVTDLLARYGGEEFVVLMPGTDEEGAKQVGEAL
LKVVAELQIPHAYSSIAEQVVTISVGMVSCMPDKLMHRDSLNKAADDALYQAKQQGRNRM
CIGSCPLDKA
>A0A086F1L6|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMKLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDLLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRGHSTTTLLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A1V6AXM3|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MKKKEKEGSTLPESRISRKKEKLLEDSEELYHLLADHMKDLVWLLDLNLNIKYISPSVEK
LTGYNLNEIQNITLEKLLSKTSFDKAKKFFSAEMTKALAAPDDYVLKRSLELELNCRDGC
MIWTENTFSFIRDEHRKPVSILCEGRDITDRRRAEKALRESEAWHRRSEERYRNILDNME
EAYYEVDLKGDLTFFNATAVTNLGYSNDEMMGMNFRKYVDKENEQKVFEAFHRVFVTGEF
SKGVDWELISKNGEKKPIESSISLMKDVDGNPVGFRGIIRDITERKRAEEALRESERKFR
SLTETAQDIILTIDMKGIITYANPAAASMAGRNDLVGKVLRDFISPEVVNQHLEMLDKHR
RGFTGTMSYESQISARDHDGLIYFDVKSTTLFYHGKPSGVLIIARDSTERKRTEEQIRLL
AIVDTLTGLFNRRGFITLAEQQLKTAYRTEKKQLLFFIDLDGLKMINDTYGHDEGDHALQ
KTAMILKQTFRESDIIGRLGGDEFAVLVVDDDELQKNILKRLKERIKEESTVSDVSYKIS
MSIGVAEYDPSRPCKVEELMLEADRLMYIQKKEKKQAGGYHM
>A0A485CR91|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MLNPSRWRNIATARTLFVMIFLAGIGLIFSIISLLYLSQQLISTKTNDIDARRSALSVDG
AIQTSINRVMSLVIDNAIWDDAVRKVYPPTLDTTWLYNTWGAGYKINNLYDGTFVLDENY
RVLWGSFHSKPFDEKNLSFFGEGLQSLISKNRQPLSEGKNMFAGITRTREGIAFIGIGLI
RPMTGRLEVYDATRRYLVITRHVNPTLLRNLGNTFQIENLTLADAPQNQYNIPIRTAGEQ
VVGWLNWQLRQPGAEAANAASPQIREIVLLAAGLILLFIVLSSLGLWKLARGERQAREIA
LTDWLSHLPNRRALIEQLERISLRGDKDPKTVVFIDLDGFKDVNDIYGHDVGDILIIRIA
DMLQTLVPPGGMLARMGGDEFAMTVANVRKPWRLILPYGCWITLILQSVLANGRCISAPV
LASPAVRYRAVPAPNCSARPISRCTILKSPVKGVLPTMTRSSIAFANTSCRLKMIFAMVS
NMTNLRCGTNRLSVRDPSGDGWRGGAGTLATPGEGRTDAGCLHLDCRDQWAHLFAGAVRA
GPRLPRPAGAQ
>A0A2N7QT84|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MPRTGALGRNLFLAACLLLGSSVGAARAAVPATAEDPAPMLDRADRIKTSDHDAFLKLLS
ELDQRSAELSSSEQWRLRYLDAWQVAFQGRYDQARPQLTEIVNLSGDPTLQVRATATLVN
ILGIGRHYEDAFTRLSVLIDQLPTVKDPEARYQALGEAAQFLTFAGQYDLAIGYAQQILD
DTALAGHTCQGLVFKIKALYHSGKIKGTDADFDRAIDVCHDSKQELFADGLRSERADYAI
KQGHADDAVTLLLAHYGEVKSYHYPALLADFDTLLAQAYWEQGDVTQARKYANAALADAV
PNEFAETRSTAYKVLYNVENRQGNPQGALEYHEKYMEADKGYLNDVSARAIAYQTVRQQL
LANKMQVDALNKQNQILQLQRRLDRKDMETSRLYIALLLTVVASIAFWLWRTKRSQLRFK
RLATRDSLTGVHSRQHFVDEAEIALRVAAKSTRDACLVLLDLDHFKDVNDTHGHVIGDLV
LKRAVAACQHHLRRHDIFGRLGGEEFAIYMPGCSASQARERAERIRQAIAATPLWGETRH
VIITASFGVASTERSGYELRQLMIDAESALFEAKRDGRNRVVYGQLGDFIVPATSADPTE
APDAIGDVANHAYGAHRP
>A0A2N7QUJ0|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MVALLCLLILPALCLGSDKDPWAPFDAPWFDRIGVNDGLPHSITTTLEQDRRGLIWIGTL
SGLVRYDGYRMQVFTAAGGKADIPDAYVRCLLTLPDGGLLVGTNAGGLSRLNPLDNTFHN
YPVGRGGTSDRKIYAMAPDGSRGVWIATERGIDYLDLTNNRITAVPLSDGMSPRSFSILQ
DREGNLWAGNNSGLFVRHAGDTHFARAEHPANDSNVDAVLSDGIWALLEDREGRLWVGST
QSGATYRDAAGHWHAIAGFSGYQRDHARRATVRAFTEMASDTIWIATDGDGVLAYEVNAG
TLHAVAHDTARPSSLPGDSVRDLLQDNSGNVWVATDLGVARYDPDARKAFALQPSTSDDR
SLANTNVRGIFVDSRQRIWLGMSSGRIDVIDLSAGAIRHLELNGVQTRRDVQAFTEMPDG
TIWVGTQGLAKIDPDTLAVHGSAIPEMDDKPVLHLLPDDDHLLIATYDGVYRYDTHTRAL
AHFNHDANDTGSLASDTVRRIARIDDDIWYVTGRGISIATSPLQTRNFENLLHRPGDNTS
LPNNLASSIAMDPQGNLLVGTYGGLAILQPRSADDPYRFTTIGVANGLPSENVNAVQPDD
YGNPWVSLPNGLAMIDANTHTVHTLGVRDGLRISSYVYAAAARAPGGELMFGGLGGLTVV
RPSWQPRDEPDAALAITYAAVNGAPLAFGRLPRNGESLAIRSRNRSLRVDFALLDYEAPP
ETSYSYRMEGFDEDWIDIPHGGLPTAIYTNLPHGDYKLRLRAQTHGMQPHLIESTVDVNV
EPRWYETIQALVAAGILALVAIVGVIQLRTLYLRRQARQLQHQIDLRTQDLLVANKRLDE
LANTDALTGACNRRRLLELAEEVRAQSPDGQACIALLDLDRFKRINDTYGHLAGDAVIRH
ACRIMQEQSRDTDIIGRYGGEELLACLPASTLEQGMVAAERIRSALAEQPLIHDGQTIVV
TVSIGVAAYRAGETLSQWLTRADGALYEAKHGGRNRCVAAR
>A0A737RGW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sendai|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1V6BA13|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin140|TrEMBL
MNSPNFLKLVFMNTKELLKNNKEEVHKFNQQIVPKVFIITVLTLFIPIISAIFSESMRQN
VPAYVLTMVTLLGVLGLSKIPKLKPYPLVFVYIFGLVVFALFLYLSIVKFPTRPAGSILT
FFVVVPLLIIDHSFRINLYAFGMFVVHMILSFVFKGVSLGSVDLINTFTSVILGMLIGRL
FLITRLKQFETEKQLKIERETDFLTQLYNRRKLYMDLNRLDQTGYQEVGTLIIDLDHFKE
FNDLYGHLTGDRCLQEFGKLLQSVSKANSVKFYRLGGEEFVGITLNMSKEEIMQLAEEIR
MSVKALNIAEKNLTLSIGISIIPIKKDQSVDYYLEGPDKALYKAKELGRDKIELWD
>A0A8G1KSF5|diguanylate cyclase|EC 2.7.7.65|Qipengyuania aurantiaca|TrEMBL
MAHEPHSGPTDRAGASPDVDPRAVQQETMLAMLERERRSLSSSLLAMALLALSFAFYALP
GPFYLLLGLRLASFTFTRRAAALLNLAVRENRRTTWPHRRMMLAMGLTGFTLAMLLLPAP
AGTPFAAQLLVGCVVLVALTLISTTLAAMRGPRDMMLASFFLTMCVIVPSQLASTANMWI
IAVAAITVAGIRMYAYNAGEHIITSAAVLVENRLLSQDLAQALAKAEYLGACDPLTGLYN
RRKLFEQRERAADGGLRQVLMIDLDRFKSINDKFGHSAGDRVLVAAADAIGARLDGMKGS
GHMAFRLGGEEFVALLQDTDCDTARRVAEALRGDITQISAAAADIGALETTASIGIARWH
PGEELDEALQRADAACYAAKNAGRNRVQAAA
>A0A1R3TI50|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MLDAKTGMLIWSMQTLTLAAVLAVLWLHNPSKKYHLCFASGFALVGIGAILVSLRGQIPN
FLSIQVGNTISLAAFGFWLAGLLKLEDRKIDGWIAIPALIWVAFMFVPPVRDSMEARIIL
YHICAAVGYFMLAGVLVMSSEYISKTRKVLIGALIVQAFMGAITASLVIPYNLATGQVVP
LTAPVAVAGSFGFIVLLMISVKMFMEDTERRLQHLAMTDHLTGTLNRRGMTDAFEMLKTK
AGRKSRHIALILFDIDHFKNINDRYGHQCGDEVLVRFCAEAGDIVHGQGVLIRMGGEEFA
CLIETDDPSKAAILAEAIRIRFSRLALFADNERFFATVSAGVFCQQAANADLDAMLTMSD
RALYGAKKEGRNRTVVRERSINIVIPADDRDEDPCDNNADRQVAALTRITHIANR
>A0A7Y6R0R9|diguanylate cyclase|EC 2.7.7.65|Halomonas titanicae|TrEMBL
MRYKDKHQLAAEWQALLERTPKPLRQAVETLVEHHGQNFADHFYRVMLEDPHASLFLSNA
QVEQRLHPSMQRWLKAMFAVDHADFESLVEQQEKVGQVHARIDIPVNLVLSGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIAAQQDIATLPRLSNSDFGLWYFHKACHAFEGVPEIATIS
RHIQQVDCEWLEVLLHDDASQRLKALGEIRDAARTVLMLLDNVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKELMLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A7C9K2T3|diguanylate cyclase|EC 2.7.7.65|Halomonas alkaliphila|TrEMBL
MRYKDKHQLAAEWQVLLERTPILLRQAVETLVELHCDRFADHFYGVMLEDPHASLFLSND
QVRERLNPSMRRWLKAMFAVEQVDFYGLVEQQEKVGHVHARVDIPINLVLNGARQLKQAF
YQQINATFATPLSPGDASVYISDHIDMAMEIMSHAYSVANDRNARTEEAYKLFALTQNIG
DERERQRSALLNWENELMFAVAAQQETATLPKLSKSEFGLWYFHKACHAFEGSPEINTIS
RHIRQVDQEWLVALGLDDMTQRLNALSDIRDAARTILMLLDDVLERASGLEAGRDSLTRL
LNRKFLPVVLSREIEIGRHSEKRFALLMVDIDHFKAINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRRAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQLADQALYQAKRSGRDRVVVQNA
>A0A3S5E6H3|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MKLRDNFKRKTIDRLDYRYHLLLLIVPIVLFVLLFVFNAPTEGWTILPLLFVCLIYVIAY
SLIYYLHQGRLMRLWQHLEQVVSINDAIYELAHLSSQYKNEHAFLDALLNKAVCIINGAE
MGSIIKVNEETHRLHFESVVGLDLNMLKQLNFSLEQSFEYRLTKGKCDRVVVVDDMKNIN
AASTLTTEEQHILLTAAKHPIRSTLSSPIRIDGKLYGMLNLDSSSVGAFSDYDRNLVSIL
THEASNAIALYQKSLQITKLANFDNLTGLYNRKNFEDALQHWQPKAHLGSYLVIIDMDNL
KSINDQQGHQVGDLAIKQVAKTILGFWKHKGIISRFGGDEFVALCHGPLEQLENDLDAMR
LKLHQESSLNLNFSVGMSAYDNDWAKSFKQADNAMYEQKRGKKKAIKALEAIAANNQLTQ
>A0A448CF74|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MKTLFSPLLPARQSHTALLCAGIIYWLTGALGQTLFSLQPENITLIWLPSGIALVMLLMW
GRKALVLIFLGSFTLNFQGMLQQDSLGLSLLHTSVAALSDMLAPAMSMLLLRRFLPQGTG
SANDLMKFVVVAGIIPIFGSSALLSANLVLGGYILPGAFWSMGQMFFFADILGIVLVYQL
YAGWVEPNALSIAKTRHILLPLIGLPLFCLVGVKFDLGWLFYVIPPLLVVLSFEVTRFYL
ALFSSASMLFMILATAQGYGPFINATPYQTNAEMMAFVLSSALTIFGVSLQRAQLRRTER
DKQTAVQEALYDPLSGLLNRRGFMPQLTNLNGPTVRYSVAMLDLDNFKMINDTYGHSVGD
RVIQLLAQLIHNHSRSQDIAARLGGEEFALVLRDIDAEQVYPVLERIRKSFAEMSIAAEE
HTIYCTVSIGWVEYQQGIAGESLLHLADKALYQAKAKGKNTIVKYQA
>A0A1C5U5Z0|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MYTVEEIKEKIGSGQWTRADVDTIIADLKASSKLTSHVGEIYYSSYGVFAYSFRDRVYPM
LEICQEAKLLLGPSMEKALIYLALMRLYFCLGFLPKVVEYGLKYAESGYTLRDCLKSVYN
TIAATFTDCGLYKEADIYLEKMLDISRLDPCGPEVDFWNSDYMNEFVYYDSKVYVKLGMG
DVKGAEQALEGIGRLLACDDISEEGKNFFRLQRECTDLYLRMHKTKDIAAIAEEFNEYMR
KMESGELKVDCLNFCIYNFGELLQVMAKVERWEDIIRIGNFIKDAPNFSGSICPVYKVMC
QAARRSEKEEIRSQVHKYERMYLEALEKEKENYDELLRLLAKEELRLVNLKDTMKKDPLT
GCLNRAAFEKSSRRFVSEHKKGCLAFLDLDYLKEINDSYGHEGGDSYLVCFAENMKQALR
LDGALYRYAGDEFLILASAREEEIKRRLHFIVEENPIKFHINGDERNIGFSYGIVAFEEK
NGNVAELVKEADRRMYLCKKRNHESILKEAKTK
>A0A1F2Q2M8|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MPSPVIASEGHSSWQTLHEWFNEPHDYEWIKHQRSGRAIIPIFRTLLGMMTIIFGLSAFY
KLIGPDTPPTTPGKALSIFMICTCVGIAACWFTQPFPGRRGLLAFGIFADLGIAAAVLLM
PDRSSATFGCTVFAVTGTFATLFVSARWLVAHVVWSTTITTTVFVLAYLEGDVDITTLLA
RGTVLFGAVTLVPIFAHLTWRTLYRDAQYSDRDPLTGLFNRRGLEGAVGDLFESSRDDSS
SLAFIVVDIDKFKTVNDLHGHAEGDHVIRRTANRLSTHLGERGVIARTGGEEYLAVIAGD
PESTTLLIEGINAALSDCSDAIPTTVSVGAVMMTAESKAWSGGASAILAATNVADSMMYQ
AKAAGGNTIRSAQI
>A0A853W0G9|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MSVEQAKALSEFCKTVIYFLSAIGMGICLHKGRNRKGRGPEKLLLLGLLTMGTGTFLSAY
WVKLGLPESWGRILGDLVLVNAGTAVTILAMYFLTLKFHLVALALKKEAVTDPLTGLYNR
RTFFRELDCRLERGGSFAVAVLDLDNMKQINDTLGHQIGDEVLRAAARALKKATREKDIA
ARYGGDEFVVLFAGKGPRVEKFKARLKENLMAELPYTGEIEVGLSTGVAYCPEDGEDARS
LLSAADARMYAEKEAKKNRYYAFGLLAENSKP
>A0A5D3HZJ5|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MLKGAVSAFKKRLRKTDCLARWGGEEFVILLPETGVEGAATLAEELRQKLSEMEIPGAGL
VTASFGVTGYRPGDTVDTVTQRVDSALYRAKGNGRNCVCVGDPD
>A0A517N6Q1|diguanylate cyclase|EC 2.7.7.65|Rubripirellula lacrimiformis|TrEMBL
MWLDLMIVMSCGGAGLACGWVMHATNAGASVATTSPESVGGVETGSPASSGDDGEPSREK
INEVADRLRAYAQTMAEDVDAHQTAVQAVNNSLTSDESKSPESVFQAITQLIEANEVMQS
QLRTAQDRIHAQSAQIQSAERRAMTDALTLVPNRGAFDKHLARQHDLGGINAGTLAVLDV
DNFKKFNDVCGHRAGDEVLKVVANMLHSKLNQYGIVARFGGEEFAVILDGCPIERAKELV
EAARAEIAERDILFEDKRLRVTASAGVAELAEGESSASWLERADKALYRSKKAGRDCGHW
MDHQTPVKIEPSIPLPAPPTVATTPVSPVAAVLNTASTASVKGSAAQPKPKKHMGLPGRA
DLAGAFDEIRNRTQSNVSMFVMAIRCNTEANPTAMRSLMQIVRATLRSVDRLGCDDESTF
LVFMLSADESTAEARSLQICRSVSAIGLDSDSGVAHPVSIGVSQVRSDEGFEGVVERCVA
LAVEAKDVDGDPVRMESFV
>A0A0D8HJF5|diguanylate cyclase|EC 2.7.7.65|Acidithrix ferrooxidans|TrEMBL
MPALTRPSSISKVAQDTQLYHWLTDAPRALPLTTGSRGKWLGLFVIIASIMGLSVSLITD
PSPQTQIIDILDVVSLLLGVGIYIIAEKIPRVGINVIVLGCTTTITIEVSIGYSARPANL
AIVFYVWVALYVFSFLSTAESLGHVGYIIVAYTVALILGARPHEPLADWILIISTVVIAS
ISSGYLNYTIRQLAITDSMTSVSNRKGWDLVAPREINRARRNGGFVVVAMIDMDGFKEIN
DTHGHPMGDQILIDTAKAIRQSVRPFDVVARWGGDEFAFMGLVSNRDEAKAFIERVVTNV
QKVSPLSCGAVVATPDHDIDNLISAADDALYRSKGNSNKRFHMVDI
>A0A8F9X3Q7|diguanylate cyclase|EC 2.7.7.65|Bacillus subtilis|TrEMBL
MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYFSTLCVSLTPSPSGFVT
KLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEGLPDVVASFLNQSMKQERL
YNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSLFEFSLFISHDQDQCLGIPAK
ELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQGTYGVLKAEGTGDSFLTDACLD
EMSLLANAAGKAFENAQLYEQSKASIANLELINETSRRLNQRLTLTDTMNDLAVRMAESF
QAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDFYNELKEKLYEGEKGVFIGNGQSVFGK
AGYGSLMAAPMIQNDRLLGFAVLLKQELYAFTFEMYKLFQALIHHATLAVTNSMLRDRLE
HLVKTDQLTELYSRVYLDEKIQYSMKIHQKGVFILVDIDNFKNVNDTYGHQTGDEILIQV
ASVIKSNIRKHDVGARWGGEELAIYLPNVPVAVGKRITERLVYAVRKNTKPEVTISCGIS
CWTTETRKSLKELVHEADEALYSAKRSGKNRLMVHDSIK
>A0A378JAA9|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MDNLDQYKAKLLESTNDVVIITDNNLENPVIKYVNKAFEKLTGFTKEEAIGQTPRILQGQ
KTDKNTLRRIKRAMPLKKSVNYELLNYTKSGEEYWLEFSVIPLLNESGEVSYYGAIEREI
TQQKNLHNNLYELATKDYLTGAINRNRFYEVAAISFASYLRGNFNIAIMVIDIDNFKSVN
DTYGHIEGDEQLKLVSSVCLNNIRATDYLCRFGGDEFIILIHGLDGKTLKNKADTIINAI
LNNEKAKVSISIGATIVDKKDTNIDNLIARADKALYEAKKKQKGSFIIL
>A0A1V5VZA3|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MGVNSLRNTIFRSIFLISGTLLVVFSIFVSVLIYKSGIDSAFAIIRQRNFAMRNYMLWYF
MPLKNTVEVLSEHSDIKKGTKITTSEKQGILEFYRIVKKIIPNINYVYSGYEDKSLFIND
YTPPAGFNPTERPWYIKALESHPYVSDGIPYQEIKDKSWLVSLGKTITDNNGKIIGVLAV
DASLQHLAEQIRVSDSSLKTSYSYVINRNNIVILHHENRFLNHNLSEVIFPMPDFKEKEG
SFHYSTIDGVSKIAYYHRIDELGWILITVVNKNEILLPIIFKIILMLSVVLSAAVILGII
TSNTLIKNVVAPLVELESYLIDSTKKEKEIQYPDNEIGRLARAIQSITDAELYKKNQQLM
DMNAQLEVLSITDPLTGLYNRRKILQEIEDEKLRAERYVCNVSILIFDIDHFKNINDMYG
HGEGDLILKELGELIRSSIRATDVFARWGGEEFMLLLPETDLTSAVAIAEKLRVAVERHI
FSNGKNITISIGVSTFIKGCSVDDFIREADDMLYRAKETGRNKVQYIKKRESS
>A0A6C7A177|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin (strain CT_02021853)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A554WL07|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MGELDLRALVLLGAIGVLTSVVLQHVSRQNRALLGKGIGFVLLSQQRLQQHMRELASHDS
LTGAMTRAAWWNAALHEVLRQRRQGAPLTPLMLDLDHFKRINDTHGRDRVVCAPADAPAP
PAATPTSGTAATA
>A0A554WRQ0|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MPPFDDRRAPPSALPTGGVHTLWQRVRGDYTLGVLVLGVVVAVVWLLPFALYRAWQGNWL
AMANDLVLSALLSGAAGYAWRSGDTRRAGWVVGLAIVGGIWAIGWAARFAALFWIYPGVL
MLFFLVPPAAAIVLGLAAIAGAAALSWGELGGHEGLLFFIFTASLTALLGYVVAQQAQQH
IRGWRTLSLLDALTGVGNRRLLELELAQAGGALGTLVVVDLDHFKAINDRLGHDEGDAVL
RRFADVTRGVLRKSDRLYRLGGEEFVLWLPQGEPQAVQALLQRLRARVAEDVQADQQPVT
FSAGVAVHAVGEPWQACLARADAALYDAKRTGRDRAAWAPPGPAMVARS
>A0A1V4WNH0|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin006|TrEMBL
MRIMGIDKRIFIIDDEKDLLFILKDFFEAHGIEAITYEAPPDLSAEISEKKPGAVLVDIF
IPNASGFDILNNIRKIDSNLPVIMMTGQPDDEKRLESLRNGAYALLAKPFRSFEEVYHIV
NNAANHYGEIQRTFELTAEIRKRHEHERLNLLELDFLKKLQLMIGETEDSSFVIKNSFAL
LKNFLDFQVFAVRMVQGEDINIQIYPNVGPDTKLMECVTTSLVGKVPERSQVQAGDKIGD
DGEPAYNYMTVDISSRDTVYGYAGLYRVLPFNESEEAIFNRFCSNIALTLEKIRLFNEIK
ALSIHDGLTGIYNHAFIVRTLEDEIERSKRYGSALSVALFDIDDFKSVNDTYGHLAGDAV
LQRLAELMKGSLRTIDIVGRYGGEEFLAILPETDGANGYTVAERFRETVEKEYFVYGGER
IMMTISGGVGRYTYGMDVNKLIKVADDNLFRAKREGKNRIVL
>A0A5J0IT58|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hvittingfoss|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAERLQELADRNMYQAKHRRAERSLN
>A0A1Y2MZ83|diguanylate cyclase|EC 2.7.7.65|Streptomyces platensis|TrEMBL
METESEPYVRLATLRQLHQVVAELNTARSLADTLQTVADGVITGLGYELSAVNLVRPDGD
LVVAAVAGSAGAEALMAGRVGSRASWERRLSMGERWGDLCFISHTEGWVLDDDDVPQWHT
AGPAPRFPDEWHPMDRLFAPMYTAANGGGELLGVISVDRPRNGRRPGPWGQEALQMYAFQ
SAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAVAEMGGDQHGRLL
RTNDALCRLLGRPASGMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLARRDGSYVWVSL
RNSVVADTADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLGARLCS
RPAGSMADAYASSATLSTDPRAPHGFRADAKEPFDGLDGFEGGPPPPFDHHVHLVAPADG
PADDGSKGLAVLFCDLDGFKSINDRFGHNTGDAVLIEVARRLTSGVRDGDTVARLGGDEF
VVLADGLGTADAQDLAVRLRNAIIPPIRVEGRAVRVGASFGIGWASCGMSAEEVLESADQ
RMYVEKRSRSKANRRAAG
>A0A021XCU7|diguanylate cyclase|EC 2.7.7.65|Shinella sp. DD12|TrEMBL
MTVRTFGKSSDETIQRQRKRLAALENLDLLNSPRDAGFDRFVRLIQQIFTVEIGLVSLID
GHRQWYQACSGLSADEVPLEDTFCRHVLVDEQPMIVQDATRDPRFVAHPAVTGPEHIRFY
AGVPLKTKAGSTVGTVCAIDRRPRSFGRKDLDILQELAGAAMDRIELMQTAATDSLTEAL
TRRAFKREAEQLIAAALRHKHDLSCLVLDVDHFKNVNDTHGHAAGDEALKAVAAACRSSL
RASDLFGRLGGEEFAIVLPHTSAEDAMITAEKLRGEIAARPISGAFGTLAVTASFGCAAL
SIVGRDIETLLAQADAAMYHAKQNGRNRCTAWSSLQAAGGIGARRRVLKAGSIIFNDRRS
TIDCTVKSLGVDGAGITVSNSAGIPPDFMLSIKAEGFETACSVIARDRQNLEVAFC
>Q8E9Q9|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MAKLGNILVLLISMFMSSAVYADTMSIDDHTPTPLNLMPWLTVTHLNTTSELADIQALPK
TKWHQFTSGDIQRLSQHNFWLTFSIQSGDESLSRILALDNPLLDKVTLYHLVGNQLINTT
YMGDTLPYQQRPLLSNIFLYPFKINANEQHTFYLHIETEGNAAVPINLWSANDLVQIAES
TAVEHGFQLGVLAAIGIFSLFIALASGSFSYSYYSGYVLCMTLLVATINGFAFRFLWPNW
PALQQLMVPMLLPLVMGFALMFTEKILQLKYYNRHMLLMCRYSAVYILLVCLLVPFTRYG
TVLYIEIVSVAVLSIIMMILAIIQAVRGQKLAKLYTIGWVSMLTGACLSSLLYLSVIELN
IKPQTPVMLGLTFEIIFMSLVLAIRYNDERKAKQRIQQEALKQAQKIRSAREEALKVEAE
TNERLEQKVQERTLELEITLRELHEVNQKLTEQSTIDSLTGVKNRSAFDKRLLAESRISR
RQETPIALLMLDIDRFKSINDQFGHLAGDQALKLIAQTLQQHLKRPTDLVSRFGGEEFAI
ILPNTTADGALQVAESIRDTVSCIGLTWEGKPIPLTVSIGVSADVIMNEQHSTELLEQAD
KALYQAKNSGRNQVKLYAPAQTEPN
>A0A1S8TQN7|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MRCDVLNVNYYFSLILFVSAVVLVFIGYFSWKRNKVYMSMCLLPVSIYEFGYAFEILSTS
LEKVKFWIKVEYLGIAFLPVVWLMLALNFNGYEERLKKSTLKLFYIVPVITLIMNYTNDF
HHLFYESLYMNNDGIFPIVEIVKGPFYWLNIVYTYSSMLAGLIIFIFAYSKAVSIVRKQI
LLLIMAWIIPWISDIVYTLRLMPFNLDLCPLAFSFSGIISSYAILNFKLLKLAPIALEKV
FSNMLDGVIILDSENNIVNFNDSSQNIISELKNIKAGDKKIDEVLKEYKEVLKALNSDSY
NESLITIKNYDKLRYFKININNIYRKNDEIIGKILIFNDVTEIKLHAKKLADNFKFLETL
MNAIPHPIYSKDEQGGYNHFNTAFIEFLGITKEELIGNTAYDVFGKGLAERYYESDRNLI
EKNGTQVYESKLKHNDNTYHDVIFSKSVVKDEHDKNKGLVGVIMDITEEKKNRERIDKLL
KLKEVMVKIGYSINEITNINDLLQLILDEVINCIDEQNSGSILLLDEDKNLKIAVAKGYD
SEEIKTFSIKLDEHRLRFNNGEKINETVIFNDIYKSQNINMLDTMEGVKIRSSISSPIII
EGKLYGFLNIDSIYNNAFNEGDIELMEYMRNQASIAIAKHKLYEETLYLSRYDKLTNVYN
RSYFEQLVNTNIYSESADKKEFCAAVFDLNSLKFVNDNYGHLCGDELIKTFAKGLSTLRG
TSDIIGRFGGDEFIGIFFDIDQGDLVNRFEELAKSFKSNPISFGERTIVCSYSYGIVNGQ
RDGMKFNELLKIADARMYEYKRLVKSKKI
>Q8EJN6|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MKKIIIHFLLASMLVFCSGLYSAWAGNFVQRVFTDRDGLEATSIRALTLDDHGFIWAATE
QGLYRVSNSKVRRIDKTGSELRLADEFITTVVNIDRDLLLLSTNAATYLYNIAKNQFIQM
GSPNLFPHFSGGVLISAVRKNAQEWRLLIDNGQIYDLSTATLTLTLVTQLPVNRDLPWRK
LLSMPDGQILVAGQFQLLLLNHLGEKLVDYQWTESMGNILDMLEDSKQRIWIATSRGVYR
FEPQTLQISPVPELPDWSTAMVEDRHGEIWFSSRAGLLKWSPDTHQLENYQQELKAQANM
ETLKAILFDKSGLMWVGGSGDGLALLASQPDFILDTFTSEPPHELSDAMVWSVFASDEGL
WFGASHLSFIARNSQKAVTIDIDGLKPHESIYGISDFIDHYLLVSTTSGLFVVDKLTLKG
SSFAQWAHGSEAFKNKVIYGTYADPKLKGRFWIASATGLYFWEQGLFEPQPFNIDGPTGD
DSPELKRPTIRTLYRASDGKLWISGRKVFGYIDEQNLFHDQRQLFSGLNSEPSISHLEEI
SPGVMWFGSYERGLFEYHLQDGKLVSLTLQWQVNCSSVFFIQKTTNANIVACADSLIRQD
RASGQIAMFTQLDGLISNEMNEGAYFYSPGAGLYIGTPEGVMHLDADKLTNRIADDHVML
ESVSVYYDNNTQVSLLPQPMMVIKPGANMVSLQITNLDYLDDSPIQFKYRLRYQGDEDNY
VLLQGESQINLAGLAAGEYVLEVLSQVNGIWSDKPFTFPFYVEQHWWLSQGFKGILLLVF
SIIALGLAWYRQRQVRTFMAMNQALTESDDRLRQSLRGSDSDLWEWHRDTQCFYLDNRGY
VLGNHANEIVLTLETLPVHPLDREKVLIQWNRMLSGDLDRFEAEYRYHRRDGNWGWLRVR
GRPVARNKQTQEIERVAGIYSDITLRRQLEDEVSLLAQAFENTSEGVLILDVDENIRVAN
HAAQHIIGSEQKSLVGLSFSQFVQMKDGLSTEVAQLLGQETSWTGERELVGQNGLVCPVW
LNVSVMQSVNQNAIHYVVVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSNRLMQSIQ
AAEQNGEKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSCIGSEHLLCRFGGDEF
VILLKNVKELSDINHLAEQLLAQIVAPFRLFGREFYISTSIGISIWPDDAMQPEAFIKNA
DLAMYHAKEEGRGNFKYYSSERNAQALYHLRLEADLRKAIERQEFELYYQPQIDILRGDK
FIGMEALIRWQHPVDGFVRPDIFIKVAEACGLVVDIDRWVLRCACLDGARWAKQTIEPFK
MSVNISAVHFRQPDFIDGVKKILDATHMPASSLCLEITEGVLMKELQVAKTHLKQLDDLG
IEVAIDDFGTGYSSLAYLRNFEVDTLKIDRSFLIDIASNGADQAIVSSIIELARNLKLTV
IAEGVETVEQLEQLFSRGCYIVQGYYFAKPMSVSDFEKYLQSQYPLDSLQS
>A0A1S8TC92|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MDTTLRSKEELISKMEELISKNEGPFSIVAADIDDFKNLNNIHGKSIGDEVIKKLISIFK
NNLSSTDMVCRFGDEFNILLVKKGAERSFMELEEIRRYLSDNTFSLNDDENIYFTLSFGV
ASYPRDAKNVVELFRVADSALFRAKGLGKNRICLSEAESMVLKSNYFTKTQLDRLSRLSK
ATDRTEAFLLREALDDLFKKYSK
>A0A0D8FR79|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MSRLAQDSVPLRRIKNMAIDSHTDGDYLNMAGFARAVLDALPDATAILDSSGTIIAVNRV
WLMFALDNGGNPETTGVGVNYLEVCARAAESGCIDAAEVLAGLRAVLAGETVESDREYPC
PSPTVGRWFTSRITPIGDPIGGAVVSHVNISRRKMSEQDLAHRASHDPLTGLANRLLFAD
RISEALRIHPSRRGATAVGLLYLDLDDFKSVNDTYGHDAGDEVLLTATHRLRSAVRRNDT
AARLGGDEFAVCAPQITLDQLTRLAHRIEVALGEPHHIHGNEVHVGASIGTYLADESVTV
AEALRLADKSMYAIKRKRSEHKLLA
>A0A5B0T9M5|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIMGENSHFACRFGQWLNN
QSRYNEDDCSYVSKISATHEKMHLSGKKLLMAIVENRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDALTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
AEGEIGITVTAGITRVQQGETLDTVLGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>W0BMY2|diguanylate cyclase|EC 2.7.7.65|Enterobacter ludwigii|TrEMBL
MQRETFVVRRSFLQWLHMRSNPGLIVNLCFLIVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRKSMRDAIQTPLAFDVLYEAISRFNAFRTRPSWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDPERISNEISAALEVGYLLRLASSVGQSEERVIYASRA
GFYLATDTPEQTSDISQRYYYLVTQPWFTQQSERNNRARAVRWFISSPSPWTGGERMITA
SVPIYFDHYWYGVVAMDFSLKTMKHLLEEATQERTEGEYQLYDTRLNMIATSEEAGSLVN
RFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKMLS
EKCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIGSALRKNDVAGRVGGEE
FCVVLPGSGLEEARGIAERIRSRINSKEILVKKSTTVRISASLGVSSAQEKDNYDFEQLQ
SVADARLYQAKQCGRNRVFWHDQDKK
>A0A7W3DX41|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00013|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A1V6A0D0|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin155|TrEMBL
MEGVNSTFNIDAFYETLIDQTPLGIAVQTPDGKVARANSAFCEMFGYDPGEVVGSQLDDL
VAREEDLSADAGDLTELVLRGRSNLAERVRVRKDGSRFPVLIWGVPIIQGDRVLAVYAIY
EDISERKVAERELARERSVLERIVVDSPDGMVLFDEEGTVFRSNPAFDRLFDLGQDEVLG
HHLWEILGGGGKEEEIRGYIRQLRDRKRLDYDAVRFRKDGSEIHLSIRAVAITGDGPSGE
YLAVYRDISSRVMVQQQLATERTYFENLFMNSPLAIALVGGDGIIQRVNDSFERLFGYYS
YECVGADLDALIAPGELRGDAVGLTRGAADGTTIKAERTRRRKDGSWVEVQINAVCFPVG
DGTTLIYAIYQDITERKMLDDKIRFFGCHDALTGLYNQSFFEEELRRLDSPRQLPISLVV
ADLDNLKLINDAFGHLEGDKLLTEAGTILRSCCRQEDIIARIGGDEFIMLLPQTTLLEAR
SVCDRVRRACERSQGGMIPLSMALGVAAKEEVTQDLMQVRKKADDDMYLDKLTRSERSRS
AIYSRIVEFLDSDPRMKTHISRVRGLAHLFGKHLALRQDEMEKLALLARFHDVGLMPIPA
EVLYKKGPLDPGEWEDVRRHPERGYRLARNLAPLSSIAEEILCHHEKYDGSGYPRGLSGE
DIPRLSRVIHLLCAYEAMTGWRSYRPSLSSEEALEEIASQAGKQFDPRLAGVFVQLHRTL
EVGNGLP
>A0A5P9EM54|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MAFQNPEAGAFHWLVDMLESVEVGLVVLDLDFRVQAWNGFMEHHSGITGSQIQNKVLFDV
FPDIPQAWLTRKVDAVAMLNTRAFTSWEQRPYLFKFRNTRPITGTEEYMFQNLTISPLTG
TNGEVDKICLLIYDVTEFASSKRALERANEQLAKLSMTDRLTGLLNRGTWENLVDAEYER
YRRYGQATSLVMFDIDHFKPVNDTYGHLAGDEVIRHTAQITRSSIRQSDSAGRYGGEEFG
IILPETDAENARLLCERIREGIEKSTVETSAGNITYTISMGIAQLTDEPENYMQWMQKAD
EALYAAKESGRNKVVVGE
>A0A7D6U4P5|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQHNTFVVKQSFLQWLHKRSNPRLVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRASPTWQIEVDK
QRTLPINGVSDAFVEKTTLLNRDDEFLDNELSAALEVGYLLRLASSSSGNEERVIYVSRA
GFFLETDTPENASDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSGSSAADVN
HFDAPELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLEEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGALFERAKILA
KQCEQQALPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A212JKS6|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacteriales bacterium|TrEMBL
MFWRENEQFRINILRQISREILFEYTPKTDTMRYQYIRPDDCSVNVTIQGYIQNKEYKKR
IHPESQENFEKSFCNVLSRSIRLELEILLNLNETGYRWYRVICQSKANAKGKVIKVLGRS
LDIHKVVTERDLAVKKASTDMMTGIYNKSTLFEKIQERIDLDGGARCAMLMIDLDDFKNI
NDAFGHVVGDKTIQFVAILLQRIFDADDLIGRFGGDEFIVFMQNVSKDIVQKKVEQFRRI
LANNQGDDFTLTCSIGILFLDGVENSVDALFRKVDDAMYQNKKNGKDGYHVWRSDE
>A0A603L530|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pensacola|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4S7LYJ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A554W4D8|diguanylate cyclase|EC 2.7.7.65|Tepidimonas alkaliphilus|TrEMBL
MRTPSSSAPGRQDDTAAPSGAWALLRARVRADYRAGVLLLGVGVTLVWLLPFAVYRAWQG
NWLATANDLALSLLLGGAAAYAWRTGDTRRAAWVVALAIVGGLWAIGLAARFAALFWTYP
GVLMLFFLVPPRAAVLLALLAVTGAAVFSWSELGGSEGLPFFAFTALLTALLGYVVAQQA
QRQIELWQTLSLLDALTGVGNRRLLELELAQAAARGGDVGALAVVDLDHFKAINDRLGHD
GGDAVLRQFASVAQAVLRKTDRLYRLGGEEFVLWLPPDEPQAVRALLQRLRAAVAERVRA
GEAPVTFSAGVARHTAGEPWTACLARADAALYRAKRAGRDRLEEAWDATGQPARTAD
>A0A1V5RM25|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin315|TrEMBL
MKDLKAMFDTMDQGLAYMRLIHDKAGDVVDFEIVRANRAHSEFIGVPNEEILHRPASTLS
PPLSKELVELNLNVGITGKSVIFETKDLLFGRYFRISSYQPEPGFVAMLMDDITNERDME
HKVLYERMLFETTLLSVAEGVISTDEVGIVQFINEAAEHLIGWEAEEAIGRPLSEIFHLV
PTDRRKRTPDLAQLVLSKRESLSLGDQATLVARDGVERYISDHASPIIGKDGELYGMVIV
FRDATEDRTKVQEMRTLSISDPLTSLYNRRHFDRIKEEINNEPYQPLTLVLADVNGLKLT
NDAFGHDAGDELLKKVAAVMKRTCRENDIIFRVGGDEFVLLLPQTDAEHAETILNRINNA
LKKEKVQNLLISVAFGSAQHNTEEGFETTFKTAEDRMYRNKLKENVTYKRQMIVSILDQL
YEKEESIEEHSKLVSSYAKDLAMQTQLSSEEVELIEKAALFHDLGKIAINKNILRLKTSQ
LTQVQTLELRRHPEIGYNILRSLDEYAPLAEAVLYHHERFDGNGYPRGLKGEEIPLYARI
IAVANAWANLTDPNSTADQVPKSVAVASLKGMKGTVLDPDLVDCFLKKAFTSR
>A0A1V5Y514|diguanylate cyclase|EC 2.7.7.65|candidate division BRC1 bacterium ADurb.Bin183|TrEMBL
MRIAKNMFPALRHLGKKAMPVFFLMLLCARAPRASDSMQRIKFDHLTIEHGLSQNTINAI
LQDRHGFMWIATDDGLNRYDGYAFTVFRTIYGDKTSISDNWIVCLFEDKDGTLWIGTNSG
GLNKFDPITETFSCYKNDPANPQSIASNYVEAIAEDAHGNLWIGTRHDGLDKFDKQKNIF
THFKAEPSNSNALVDNNIWCLYIDRNNIIWVGTELGGLNCYDPQIQKWKIYKYDPNNPQA
LSHYGVSCIHEDRQGNMWIGTVRGGLNCLNKKTGIFTSYRNDPNNPKSISNNYVTDILED
SSGDIWVSTSSGGLNKFDRVKGEFTAYRADRLNPHSLNDDTIWGMCEDRSGTIWFGTSVG
GLNLYNRKKSKFTHYYHETNNPDSLSDNTVWAIWEDYESELWVGTSNGLNRFNRSTKKVT
RYFHDPSNANTLSHNFVWAINGDDAGNIWIGTRGGLDCFNKNTERFTRYYNIPNNASSLS
NNTVRCVVRDSDGSFWVGTNNGLNRLNPRTGVFTRYFNDRNTPINLANEVIRTLFLDSRE
LLWIGTNEGLCVLDISQNTLSRFSHDPNNYASIRNNRIRGITEDSQGNIWVGTIGGGLSK
YDRDSGTFLTFTEKDGLANDTVYGVHEDAEGILWLSTNKGVSKFNPGIMLFRNYDTSDGL
QSNEFNTGASHKNRKGEIFFGGINGFNAFFPKDIKDNPIAPTVVLTSFKILDKPARLDKP
IYLADKIPLTWRDRYISFEFAALDYTAPEKNQYAYMLEGLDSDWIYSGHRRFGSYTNLGA
GSYTLRIKAANNDGIWNESGVSLAINIPPQPWHTWWAYTLYGIAAIAIVLFYVRIKTREN
LLASERKERHLSESLRAIAKALNSSLDLSDVLEQILSGLSQIIPYDGALVLLKHGEDFRI
MAALGRRRDEPMKRHIKTREDSILAEIVNTPQTRLYDNVSGNERFQDLQAALEEEMAAWI
IIPLVSKEEMHGMLIIGSKSRGSYQDYHVLIADTFTEQAATAMENARLFGKVKRLSLTDG
LTGLLNRRHFFDLAQREFQRAKRYGSGLGILMVDLDNFKHCNDTYGHLCGDEVLKIVASR
LRQSLRTTDILGRYGGEEFSILVHEAKSDEIEALAQRLLESVSSAPIITRECKNPLKMTI
SVGVALLADDNPTLESLIERADNALYRAKRKGKNRYEMD
>A0A554WBW4|diguanylate cyclase|EC 2.7.7.65|Tepidimonas alkaliphilus|TrEMBL
MSPQGLQLDHARALLRQEGIALPAAETPPSLQELQAIIDGLCLLSERDPLTGLPNRRAFE
ARAQQELDRACRTGEMALLLVVDLDHFKAINDQQGHAVGDAVLKEVARTLQRSVRPMDTV
ARLGGEEFAVLLPHVVPARAGKLAERVRLAVAEARVPLPQGGQLGVTASLGGALAAPWVR
STWQHWLERADRQLYAAKNAGRNRVCLEPVPHTEVSAEEKRWLLGGAELGVDRIIAGTAE
AEPDLT
>A0A377ZLJ9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNRVTRMPFDSPERRRSRDGAA
>A0A0D6PTZ7|diguanylate cyclase|EC 2.7.7.65|Gluconobacter frateurii M-2|TrEMBL
MTVDTLPITTAPLSPDEMEWQLIIDAVEPAIRLIVADIVEDRAPAGVEHFYSTLLNHPEA
TPFLSNQIVNDHLHAALLKWCQSLFTPVAPDLSSLVATQRRIGLVHARIRVPLHVVMHGA
RLLKSTLRQSLFESLTSSTDLAKAIDYVENMMDLAIEMMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREIQRAALLDWGHKILLAICCNAPPPLPLLEASGFGLWLNHKGSLLFPNTG
GIEHIKTAIRRIDQVLIPSLATETPPAAARIHELQAQIEEIRFLMDDLFKKSEALESGRD
PLTCTLNRRFLPTIMAREVAQSIRRKVPFSILMIDIDYFKAINDRYGHTGGDAVLREVAE
KLIASCRTSDFIFRYGGEEFLVALVETDLQRAFQIAESIRESVTKISTQPTGTALSVTVS
IGVAHFEGHPDYTHLIEDADRALYYAKERGRNCTVIATPDLASLPRL
>A0A8F9MSD5|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MSDESKKYISVIFKEWLPLYDGLKPEVKAILKNIAAEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKDQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDHQTGLATIHYAVMAINMAIEMMCHAYTLSHYRATKNEEAYRLYSLM
DNVPMEYGKQQASLSGWENSAIFNIVSENKNDINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLITQVDNLIIGWKSSDSGAEYKNTQTLLQSIHILCQKISSQLGVIFSSLSQMQN
GKDSLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDNWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSAGFAVHTGHPDYNRLLRDADSALYVAKRSGRDCVKMHQVEQDPQH
>A0A087DHA8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium stellenboschense|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKVEPDLIVLDVML
PDIDGFTVTRRIRQEGINAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVDDDPIIRVGDLEINEDSHDVTRAGQTVDLSPTEYKLLRYLMDNAGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGVMVEGEDGEKHKVTPLIETKRGIGYMIRE
PKS
>A0A1V5CIG3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin002|TrEMBL
MKDSGLFALDILDVAAAWINREYIHKNANNRYCSAVNRLLDEVVNRSLADIWGSETFDTY
LKTDVDRCLSGHQVHRETSLDFPAPGLRLCKILYHPYPDTGGVPTGAIVMIHDLVEPEAE
KVNLQTSFEYLTEASREAIILVRDGVIEETGETFGRLFGYAGKDARGKPISDLIAPDQRT
QSMEQIQGQAGGIFKTVGLRHENLRFPMEVNFRRVHLEGRELTVWAVRDLTKFEEIKHQV
EAYQKHLEQMVRAQTQRIEKRESKYRSFYENAIEGMFRVDANGRLVSANTALAKMYGYDR
PEDLIRTASDLGDVYTKPKDGGKVTKLLQNQGVARDLETELYTKDGGRRWARMNVRAEKD
KDGRILYYEGTLEDITEKKWAEDKYRNIFLNATEGIFQITPEGRCFNANPALARIHGFNS
PEELMQNATDISTQLHVDVETWYNYLALMEENGYVRNHLWKMYRKDGSIAWLSCNARVVR
DETGQVLYHEGTIQDITDKQLMVDQILMQRDLALRLAQTGAVDAGLALVLETAVKASGME
SGGVWLKGPGEDMKLISSINFSPAFEKKCSFMAVGSRHWKRMMNKIRMVMAPTRESMPNI
HEEGYKCAAVIPILHDGRVIASFNLFSRTKDTISEQVLINLDFLAGQLGSIIVRMGIQQQ
VEQEIKTRREAEKALQAEQQGLEEANIALKVLLGQREKDKEDLEQRFVSNVNELVLPYLE
KLKKGRLEVLQRSTLNLIETNLKEILSPFRVNIRNFNLTPRQMDIVTLIKQGRTTKEIAG
LLNTTKDAIDKQRFIIRKKLGVNKDKTNLRSLLLSLQ
>A0A811GDY3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MSLLRKIRMSIFHYWGRFRFHLLESDNLIIYWPNFDKGVLLLIFGALCQVSAIKWYLFSY
FSPDNRVWINPDFFLIRIVTVFTTLVIFSFLTLLSFRYKRNKKFRTFIAYFAPLFFGGVM
IYAGYTVGIYSPATIAGFVNIVLIGLVFYSREIIYSIAIPASIFTVVISYLTYNGMIRYA
PVFSDVLTMSEFYHNKFWIGSMAEVYLPILLVSVLFFEILLSQWRRREKIIKKMSQTDGL
TNVFNRRYIGEELSALERKNKTAYAVILLDLDHFKLINDQYGHDVGDTVLQRVAAILCTT
TREQDIVGRFGGEEFILILKDQNLQQAIEIAERCRRIIELEDVQIETGENLKMSASFGVA
LSLPHLNKEQTIRMADRALYLAKQKGRNQVRHYLELNLVPSA
>A0A1V5PA77|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin356|TrEMBL
MLNTVREEAGLMQDKLRIRRSDGTYIWCHVLVATLRDESGRPLRVLGKITDIDSQMQETE
WLRQKAQQDSLTQLYNKQTTHNLIQRFLLREGKDGIHGLIIIDVDDLKHINDTQGHLSGD
AVLVELAAKMRSLFRSTDIVGRIGGDEFLVFLKNVNSRSQLKLQAKSLIDAFTSKADGIE
YSCSIGAALYPEDGETIDWLFKNADSALYNSKRAGKRRISLHGETQL
>S5YVE2|diguanylate cyclase|EC 2.7.7.65|Paracoccus aminophilus JCM 7686|TrEMBL
MSGRIMIVDGVPTNRIVMKVRLAAASHDVTAVGSGQEALDRLAADLPRIVVIGSALPDYP
AAELCRALRRRPGGQSFAILVQATNGQGAEALHAGATCLFDPQDDEHTLLARIRSLLREM
PDSAEAETSGAGWQITAEPVRQTRLRAVFIADQIGTGLSWRYALQDHLGCDIDLRDPERA
LSEAQSGPSADLYLIAADIQRRGDGLRLMAELRSRPLSREAAFLVVVRPDRSDLTAMALD
LGAADVLPHALIDRPTAAEAGLRIQAQISQKLLSDRRRREARRNLVWAMTDPLTGLYNRR
FAMPRLQDMIARSAEDGKGVAVLALDLDRFKRVNDGFGHAAGDQTLIAVAERLRDALPPD
ALIARIGGEEFIAAAVIQSPDEAQALAEALRCAIGESPIHVEGDDAAIELVMTVSVGVAV
MVAGSPTKSLTPELLLARADRALLIAKSQGRNRIVVAPQGLAA
>A0A3P8M412|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTNWAYGITVALTLASGIAMLMASNADTAERQAVQQRQIFDQLTEEVETDAWALSDLARA
YVINKNPDVLEEYRQQAQATIAIELRLGKLKDSGATPQELALLREGLRIADELQDEQQLA
LATIARGDDKEALSLIYGKPYEQDLERVQTQIDHFRMLLEGRANDAIAQATEKSHTWRSL
SELMVGLTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPNFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFEDVIKVAELFAPNIAPE
IPGRLYILDLDPWQMRCVASWLSPPDEPEVFHPENCWAVRRGLSHPPVNGEPDIACYHLP
ESSAQWSLCVPLIAQGEAIGLLSFRNVTPATAPSRAYLELMAEALGLALANQRLRNALLE
KALFDSLTGLRNRHHLEDALHTQMNLAVRNGTPLSCLMIDIDHFKAINDRYGHEAGDLVI
KNVATIVQRAVRDIGMAFRYGGEEFLVLLAGTNEESALACAEDIYNNVRNMTLRYGLSEM
GQIDVSIGIASFPQHTQSDSLLRAADAALYRAKELGRSRIVSFGMLKTD
>A0A485B782|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSPEEVRSLAQSILENVRTILINSDYPLSVSIGVGMRGRDEPQEAFIKKVDEALYKAKNS
GRGRVEWAAA
>A0A659LUT6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E2593|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKRTTNSLITFMGNRYYL
>A0A5E4YF14|diguanylate cyclase|EC 2.7.7.65|Pandoraea horticolens|TrEMBL
MPDAMPAVPSQPTASSYAANGASGASDDALMFDLAPVSLWLEDFSGVKQLFDEWRAQGVT
DLRAHFKTDPAHVSACSRRIRVIKVNRRTLTMFNAASLDTLVANLPRVFRDDMLKTHVEE
LCQLWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHESTFERVLISLEDVTELEHARQR
VTMGEEYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVHPEFVERCMNEI
HVLDVNRHTLAMFVAPDKATLLARLPDVFRDDMRHNFREQLIDLWDNKLFQQREVINYAL
DGNEINVHLQFAVLPGHEPRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYV
DELNRLERKGPYPVTVIVADLNGLKLVNDQLGHAAGDGLLRRAGEVLGKAIAAPQIAARI
GGDEFALLLPSTDTTGGAAMIESIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEATIQ
RADLLMYEEKRSHYAGSVNERRATDGTGGSGA
>A0A378ZLW3|diguanylate cyclase|EC 2.7.7.65|Paenibacillus thiaminolyticus|TrEMBL
MNRLFTPEFSGSTAVAVTSACMMYIVFIMLLMTVRLYSRQRSGAYILFIAALLLIAFERT
LDLTDYDWFPGWFDQYGIGRTALQAFSFLLMNLAVLRLYKRSNRRMRVYVLAALLLLAGA
AALSLILAEQYGMSAKPTWPLIVYHMTFTVFCYFWIGPRAGQRVKYAFTLLVHFLMNLSS
AVNSIYFGGMNTLLFYLEHGLPLVYFTLMFFILFERVVEHLQRTYRSSITDGLTQLYNRR
YLFKAMQSYVQKEAAVSLIFCDIDNFKRLNDTQGHDKADDELKLVSAIIREEVEEAGIPG
RFGGEELVALIVNPHARVEQFAENIRRRVEAETSVTVSVGHSTLRSGMTPEELVREADQA
MYHSKTTGKNRVTDYETIGSPRQRKRASAGGGR
>A0A737EQZ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica serovar 45:a:e,n,x|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A654DAU3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MQKIDLRRLIMLLAVATGVVTLINVLFASYLTQRDLLMSQALEANHVYAAKQALNTDHLI
RSSQAHLAFSARQLIGRLQKPEYMQQETDRLRLQSNDFNSVFIVGADGRVLSTSPSGLGL
VGTRPQTQGALAIIGKRTPIITDPYVGSTKRLLVVMSHPIVDSDNRYLGYVSASIYLQEK
NIFNAILDEHYRHDGSYAYVVDRNGQLIYHPESSGIGEPSSANAAVKQVTDGKDGALRLT
NLKGVDMLAGFAPIKSTGWGVVAQTPTTSTLAVLNELMLDTLLQTAPLSILTLLGIWWLS
QWIAYPLKRLADNVKAWEEPEALERFRNIKTWYFEADQLKFTIIKGVSLLQARLGKLNRD
SITDPLTGLNNRRGLRFALDRLLLKDQGLSVIALDIDHFKDVNDRHGHDVGDQVLKFLAG
QMRECFRADDILCRVGGEEFIVLLPELGIDSAHKIAERLRLSMASQPSPSGEVVTISIGV
AYMPVGGDSIEIVLIASDAALYRAKEQGRNCVVSTSGP
>A0A1A8Y176|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MPKMQPGRTSRTLTGLAAAVALAITVLPPLGLFFIQREGLIHSLEADAKVQAIVVSEIVG
RNPRIWNQAHERLKEGIEPIRDNARTTRIVDDQNRLVTAVTAELKWPTIVRSDEFFDSGF
AVGRVEVIASAASILQQSILAFAISATLGFLVFVPLRKMPAKALKRASESLVRGELSRSL
VDGLSAGVVLTDDQLQVIAFNCSATSIAGLTQPIAPKTNLLDCFEGAIGDDGSPFAAEHW
PMRLALDGGVSAGPATVGLRSSAGRPVWLSVRSMPIRHGEENENTAIVTSIEDVTEQKDN
ADRLLITERAVQSSHDAIMITDAELRIISVNDAFCTITGYESDEILGQIPRILQRSAQHE
QDFYDGIWARLSDTGSWNGEVWDQRRNGEAYPAWLSLSEIRDPGGRLTHYVGTIFDLSER
LKAEQDARRLALHDSLTGLPNRTYLRESLSQALAAAQRHEWRVGVYFIDLDHFKLINDTM
GHQVGDQVLCEVARRLKSVLRDEDTVGRLAGDEFVAFTPNVDSDAAFVTVAEHVLQVMNE
PFAFDNDNLFVTPSIGVVVYPDDGADIDALLSNADTAMYAAKADGRANFKFFTEEMNESG
RHQIETTRAVKHALELNEFVLFYQPKVLASNYRQITGTEALIRWNHPQRGLVPPGQFIPV
IEGTRLIIEVGNWVLNEALRQAREWRQQGIPVCISINVSPLQFQQQDFVPGLRRLAERHE
FVAGSIRLEVTENLMLTNPEATIEKMSEIHELGFLLSLDDFGTGYSNLAYLARFPFDELK
IDRSFVCRLTHERTVEDIITAIFMGGQSRLAISPLECGWHRPHNRIRI
>A0A1V5Q0H5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MKKIYDDVLHFLIHHSIIFTVIIMCMVHASLLVLAWAGGAPELALTNVVSVIVYLFCIIL
CNFGHITPVYVSILLEVGVYSAISTHYIGWDTGGFFFLFAIVPIIIYFGCFIFKGVQRWI
IAISLIAIFIEYVILYLICVDRVPVYDVGFGIKVVLMVFSSFVMFFGVIFYNGMHIYASE
HEVISLEEKNEKLTEDAKIDALTGLLNRRGFMPIVEQTFKSKDVEKYCVAFGDIDNFKRI
NDSYGHECGDEVLMHIARLITKEMSECDVCRWGGEEIVILMKDYDLKEARTKAENLRKII
ETTPTVFYNVRVPVTITIGLCDNAAADSSPDDVIKAADARMYYGKQHGKNIVISEDISED
D
>A0A549V911|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
METYLQTVKDEWVQLINETDPYVHQLAAQLAHVHAPVLIAEFYRVVLADPNAAEFLTTEQ
VERQLQEALRRWLIDVLSCQVEQVEGQMRAQQRAAAVHARIGISVDLVEMGFRVLKKLLL
PLINTGPHTSEIKLNIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTNALLTWEMTLLYKVMFDSSIGNSSPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQDFDDIFKDIRISDDALASKPRRVKFLQQTRNILSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREIIHASRSGIPLSTLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRGLAPI
>A0A679JS50|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MAHGASAVCGYDAADRVTFWNERFLVFFPELATFLQVGTPYLDTLEPFLALQHPQASALE
RADEVRNALFRHVHEEGPVQYQRADGRWLELRMFPQPDGGRVKIWSDVSAQKAPGSEGSL
LQGLMAVANVGLIVHDAAGVLRYVNSRYFSEHFLSLIQRVPSIERRGRQQGGYWAKFRDI
FGDDETFEELCDSTECGPLAAPATMRARNGRFYRVQEQAWDQGGTACVWTDVTELVQREN
ALRAAHRELSLLNRRLIDLSETDALTGLPNRRRFNTAIQSAQAAVRGGAHASVAIIDLDF
FKSINDRFGHDVGDVALVEVSRRLRALVPGEVPIARLGGEEFGLVFEAMPLLEAHACVEA
VRQSFSEHPFMSESESLSLTVSIGIAPLMAEREASASLKEADMALLRAKARGRDCVVLAG
QAAAGQGTGAADAQGPGAALLAAGVFADEAGLDATGLRDKYAPAAEHPAFAFANWEKAVR
DGTTLDHYWGWVEYQISASQQAPETE
>A0A0T9LRW1|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MQAPLIPQDETKRIATLRAYNILDTSPEERFDRITRLAKRLFDVPIALISIVDVNRQWFK
SHPGLVTSETPRDISFCGHAILGDDILLVPNALDDIRFSDNPLVTDDPGIRFYAGCPLVV
PNGSKLGTLCLIDLKPRILDEYDQQLLCDLAKMAEQEIAAVQLATIDELTQLTNRRGFEI
LAQHALTFCSHNNIPATLIFFDLNDFKEINDCYGHAEGDKALVTFAEELQLFFRETDVVA
RLGGDEFVTLLTASSCNDIPEILNRFKIALELRNSQELRGYNIGFSVGYANCNLDKDTPI
NELLAAADSSMYTHKLELRTKKPPFSKS
>A0A0H5LUJ1|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVSAVLYTQNSPLWLWIMLALNGLVWP
HVAFLLASRSEEPFEQEILNMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFSPETSPLQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQERLADLVF
EQAPPLQLRVSAGIAEYRQDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A0T9LHD3|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSSIFSMILPSPETPAVTLPIVLITVISLSAAAY
LIFISKNYADKLNLFSIIMGMLWAWQIILKYEYLGTNVNNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPSALTVILLDDFQNIFRILFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKNGRNKVAFAGEKLSNVESSP
>A0A0T9MWE2|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MSLTSPPEQKERGSRQLPYSSRMNTRRSGLSFAKRTYLPRVFGLGVGMFCVSSVLYTQNS
PLWLWLMLAINGLVWPHIAFLLALRSEQPFDQEIINMKIDSALGGVWVAIMSFNALPSVV
ILSMMSMNNIASGGKNIFCKGLALQISCSLLTAWIFNLPFKPETSPLQVYACLPMIIIYP
SLLGLVTYRTAKRLAESKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLI
LLDIDNFKAINDTFGHAVGDEAITILAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQT
REVLTRIQEKLAALVFTQAPTLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRN
RIELAS
>A0A7Y0LQF8|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNIVNKKIDLLILALLVFIFLIVGIVILSIRTENKLNVFIMLAIIFFIIMLTYLSNSIVG
LITSSIIIFMYTSYILYNNITYNMDVEFISYMWIIAIPISSIIMGNLNKSINELQNTNKK
LSEQYKELVTIDSETGLRNLKIFYNDVNMEISKSIRHNTDFSLMIVKLPYYGNLQTIFGE
SKTNKIVKYIGSNIIECTRNEDIIYSLQKDMLGILMPNTSLEGSKVVKDRIKKRIKELNL
DLNNRGKYVNIDVKIAFLQYRDSFGDSINFKNIVEEELQYDV
>A0A8F5F2A0|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MTPPASEPAAPDESAPLHVWGPGPLVRSLAVLLVAVAVVAGGLSAWLVSRSSEPQALQRI
LDQDGGEVEMLARMLSSKMELNFKMLAALADGLTPQVLGSTARLRAWLLQARPGGRLFES
VAVLRAPEADGLQMQGANVSAIEQLEDAEQALARRAWQEGKPLVSGVLGGRTAQARLVLA
LPVLGEDGHTQALVTGSLRLQSQNLLPPSLALPERENTRYLVFTHEGVIVSHPDPARVLG
LVRDEPELATLFSGKDSAAALAQPGRVVLGDGTVVGWAVVGLPGWTVTRVNHAPSLLKPL
MAAEQRLWWLVAAGVALVAVAALLVLWWLMRPLTLLRQRARAVLAGEHPASVPWERQNAA
RARGEVQDVVRVFARLVQLRRQQQRSALALARQLEAVLEHVPLGIVLTHAQRIELASGQA
CRLLGSTPGQLVGRDLLQLVADAPAGQSVAERVRADFAAHGRFHGELALTRRDGSTFWAQ
VQGEPVHLGDLSAGVIWLLEDGSAEREARLQHDWARWHDPLTFLPNQAALVRKLPLLLSD
QVAHGAAPAGAPAPEVVGALLHADLDHFTLINELAGHDAGDDVLRYLARMLQSLVRQMGW
VARLGGDEFAVVLPGADLERASALAEKLRAAVAQWEPTYHGRSFSLSLSMGLVLLRPGDA
VTDVLASADMACYGAKRQGRNRVQLAQSGAAANAA
>A0A450CC41|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNFRLPKKRLPKKIIFISIILISIILFIKYDQNGLREREIINRGKYLSESLVADKEYDEA
KKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVIDSLEKMRESDVKLSDECRF
NIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKARLDVDLASILLKVGSYETAE
KLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEVGEYDKAIEISSRIKDYKKFVNTDDY
NDFEIMASIMQSNAYIGKNNIQKAKTFLEKADYLIKSDRTVHILDKDMYYYMAMGNLEYK
SKNYNSAIDNYKKSLEISTKRKLIQEKIKNLNKILNIYEKQGNVKSLNEYQKILINEYKE
NKSIRDSETSFYIIDKVSNESKLFEKTKKEIKYYKILFTVILIAILGSTFLYNRLKYFKA
QNLHDGLTNVYNRKSFDIMYEKYIEKDDNFALVMIDIDNFKLINDNYGHKFGDVVIKGIT
NTICVMLEQDDKVFRYGGEEFSVLIRNKSGEEVVDIIDNIRVAIANKKWSEDVTVTISAG
VAHISGSKNVLEEADKNLYKAKQLGRNKVVYK
>A0A8B6IBN4|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MQVSILTAIIVIISSSCVYFFNYTLTYKNMIYSLSERSKHIYEYVERNIDKNTFTEINSK
EDQSKKSYKSSKILLESVKNTTGVMYLYTAKKTKDGSLVYVVDGLNSSRSDFRNAGDLIE
KEICGDINKALDNHILLPKKIKSTSWGYIFISYFPIHNDVGKVVGVIGIEFEAKHQYNTF
KFISIVTPIIALLTCLISALIAVILFKRISNPTYTDFANTDYLTGLKNRNAFEIDMNNLN
NSNLKNLISIISIDLDGLKKINDKFGHQAGDLYIKQASKIIQYVINKKYIVYRIGGDEYI
IILKNLSHKEINSIINNINLKIVEENSTNELKLSMSIGYAIFDEKVDVSLFDTYRRADSQ
MYDNKRKINKQYQ
>A0A7Y0LQ62|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNFRLPKKRLPKKIIFICIILISIVLFIKYDQNGLKEREIISKGKYMSESLVADKSYDEA
KKVVKTSFESIPAKKYNKVYNEVWDMLKTISYVPDGTKIVIDSLEKMRESDAKLSDECRF
NIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKARLDVDLASILLKVGSYKTGE
KLIKDSFKIDIDEGEKNGMVRLYALINLAEIYVEVGEYDKAIEISSRVKDYKKFVNTDNY
NDFEIMASIMQANAYIEKNNIQEAKNLLEKADYIIKSDRTVHILDKDMYYYMAMGNLEYK
NENYDSAIDNYKKSLDISTKRKLTQEKIKNLNKILNIYEKQGNVESLNEYQKMLINEYKE
NKSIRDSETSFYIIDKVSNESELFEKTKKEIKYYKILFTVILIAVLGSTFLYNRLKYFKA
QNLHDGLTNVYNRKSFDIMYEKYRAKDDNFALVMIDIDNFKLINDNYGHKFGDVVIKGIT
NTICVMLEQDDKVFRYGGEEFSVLIRNKSGEEVADIVDNIRVAIANKKWNEDVTVTISAG
VAHISDSKDVLEEADKNLYKAKQLGRNKVVYK
>A0A450CJA2|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLKKLLLLIIVITSIFTSCIFSFDINAIGNDNRTIRVAYPIQKGLTEIDEQGNYYGYTY
EYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENGEIDIMGGMLYNEPMQKIYNYAGN
SYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVIENSKTRLKELDEYCKINSMSPELVY
CKTNDEQLEALKNGKADVLLNVSMNQIEGVRTVAKFSPRPFYFITPKGSTDLTQNLNSAI
NNIEQKDPYFSTTLYEKYFTPENNQMFLSDEETNYIKDTEKLKVGVLLNKPPFQNIDKDT
GELRGISIDLLNHICDKTGLEFELVPVKSQEDLENMTKNHEIDIVAGMIYDYEYSREHNV
AMSRPFISTQYTMMINNKLNENSLDGKRIALTKGINHDGQFEENIVWYDNLEECIEAVNK
GYADYTYGEGYSMQYYMNQPKYKNVRLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISI
SSEKMQSIVYQNTTYRQDFSLLYIMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEK
ISLELKKHTQLYEMTSEYFFEYDYKQDKLIISMPERGIETYYGLDKNDKEGENGNTTNEI
DKIRREYNKKFFNVIKSQENGTTEMYSIMFDDTFHWIRITSKIIYNDRKIPMYVIGKICN
IDSEKEEKNRLLDKAQRDSLTNIYNAAYIRKLTAQNLLNLSTKKNGALLIIDIDYFKSIN
DTYGHLVGDKVLIDVAKALDESSANDDIVGRLGGDEFSVYINDIINKEELINKCNDVYNH
IHFIKLPNGESLSISMGVAISRRGQEYDELYQIADNALYDSKRQGRNRFKIV
>A0A4P8YPN0|diguanylate cyclase|EC 2.7.7.65|Jejubacter calystegiae|TrEMBL
MLADRSQRKSFFKNPRRVVNICFTFVFICSTLLTWREMAVLEDAWISNQRNSLDNVATAL
DRQLQHSVDNLLFYRNIMSYALRYPISTDKSRQAMADFERQRTHEHWQIKLDVNRSMPLN
GVSDEFVGTSGLLLRDADYLHGELSGALEFSYILQLSDNSRDLQHRTYYVSRAGFYISSR
PPRNDEQLVSRYYRQVARPYFAQHSERYNKGRGLIWDHTWDPTRGGDQVITASVPLDYEH
RWYGVLAMDFTIDSMHQFLQRALQDGNEGVVLLYDRKFNAIATSADAMPEGKMFTPTQLA
QLARAMESKNEGEIRMAHSVVTWDKLNNFDGVLVKIHSLDEGIRGEFGRISVVLGLLWVL
FSAMLGGSWLLIHRLVKNMMNLQSTLSWRANYDTLTRLYNRGAFFDQAQYLADYCRQSGQ
SFAVIQLDLDHFKSINDRFGHDSGDRVLASAGAILSASLRGDDIAGRIGGEEFCVVLPGS
SLSQASAVAERIRERINGKEILVRSGQTLHISASFGVSCSQEHGDYDFEHLQSIADGRLY
KAKEGGRNRVCDSD
>A0A329HPZ4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RIT 418|TrEMBL
MNKQHHRVLVTSSHPLLRLVCLGLVTFIFTLFSLELARFGTLLAPVWFPTSIMMVAFYRH
AGKMWPGIALACSFGNVFASWLLFSWESISVIYTSINVIEACIGALLLRKLLPWYNPLQN
LNDWVRLAIGSAIVPPIVGGVLVHLLVPDDEPLRHFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPHLLFETLVTMAITLAFSWISILWMPWPFTCIIVLLMWSAVRLPRMEAFMVFL
ATVMMVSLMMAHAPSLLVSQHSNAMLNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCQFLGYSQAELQSLTFQQLTWPDDLNIDL
EQLQQLLNGDINTYSMEKRYYTRSGEVVWALLAVSLVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLAPDVISWDKRMFELYEIPPHIKPTWQLWYDSVV
PEDREHAEQVIRDSLTARQPFKLEFRIRVKEGVRHIRSLANRVLSKDGDVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWPQGEAIGQPL
LKVLHITFGVKGPIMENIHSGDISRSKMDQELVLNCRHGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTRLANRVSFEAHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
TGRLIHSINNYHFMWEGRLHRIGASAGITILDDANYQAAEVMSQADIACYASKNNGRGVV
TVYTPQQERAHSMRSMMSLDEQWHMIKDNPLVMMARSVASPRIPETCSFWLISLRLWTSQ
GEMQEEQAFRAGLTERELLHALDRRLFGEFFRTFAALVATKGLGVALPLSEAGLSSATLV
DELLDHLQNGPLPGRLLHLVIPVNVVRSEDVKLQQGLHKLRGAGCRVVLSQVGGDMDIFN
HLSANVADYLMLDPDIVTHVHGNLMDEMMVTIIQGHAQRLGMKTLAGPCNQPIMMDTLSG
IGIDYIYGDTLSEPKPLELLLNTSYFAIN
>A0A6N3EGJ3|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MKYHIFLIITTLLIIELCNIYICKIASFGNKNITIHKNYKYIFLIKPLTFLIIIFTKLPL
PLYYILFYIVSHKLLLSRKSSTNNHFIPNMAVISFCILHLITVSTISLVKNTSPDIIFAN
MTYKLISILIASILDFILWYSMNKIKEHIYIITQNQIEFSLFLKFIWFTLGYILFDSIQI
TFAPPSSLTSYFILGSNILLILQLIIFINHIYSIEKNIYLEKEHHRLKMIKQEQLLKVNL
LKKKANIDELTSAYNRKFAFEKIQHYIDNNLLFSLIYIDLDKLKTINDTYGHLAGDNYII
NFSSIVIENLGIDDIFARIGGDEFIVIMPKSNENTTKEFIEKISKIMDNKISFSYGIVEV
SSENKMTVEEIINIADIRMYTNKQNNHKRNNN
>H8FVI9|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MAPPSPSPVLSVLVVEDNPGDARLVKAYLEEDQARPFAVTCVSYLSKALEFLKTHPVDVV
LLDLSLPDSFGLDGLAQLRQAAPTLPVVVLTGTVDERLALEALRQGAQDYLVKGQGEGDL
VRRAIRYAIGRSRADAALRESEARFRALFDNAGAGVILTDAEGRYLHCNPAFCAMVGYSE
SELHLMTFRDISHPDDRDSVNHLYRQVISGEIESCDITKRYLNRDGTVRWGRLTVTPIRD
TEAGQLRHAVAVVEDVTETKRLEDHMRLAATVFENTGEGLFVTDERRRIIHVNPAFTVLT
GYAPEDVLGKTPRILASGRHPPEFYDRMNESLVKTGRWQGEVWNRRKTGEMFAEWLNIAE
VRDEHDRLTHYVAVFSDITSRKEDEERLSYQANHDPLTRLPNRTLFQERLSRALTRAHRN
HSIVTLLFIDLDHFKQVNDTLGHLAGDCLLQQVAERLSSCVRQGDTIARLAGDEFTVILE
DVTEARDSAIVAQKILSLMAEPFDLQGHEARISSSIGVALYPNDGDDPQTLIKLADAAMY
QAKNQGRNACRFHSESVYAQAFERLGLENSLRLAVERNEFELYYQPVFAADTGRVMAVEA
LLRWHHPEIGLMTPDHFLPLAEETGLIFPIGRLVLESACRQTRLWLDQGIAPPRVCLNLS
ARQFHASTLADEIAAALAESNLPAAMLEFDLPESCLTEKGPKTDSLFTSLKTLGIGIAID
DFGSGHSSFSLLRQMRTDTLKISQDLVRDPAGSSGNTEVIQAIVAVAHGLHIRVVAPGIE
TVEQLTSMIGYECDLLQGFLFSPPLPTEEMTAFLRQGIPPPALANRI
>A0A1V4XGU0|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaB.Bin095|TrEMBL
MIEAKRTHQPFQTGAKNGKEPLPPSESERKYREMLDSIDDGYYEVDLTGRFTFFNDILPR
LTGYAAEELRGANYRILMDDANAAQVFQAFHEVYRTGAPARLFEWKIMTKSRTPLQVQTS
IFLIRDQKGNPIGFRGLTRDITEKKIAEERLRQSEEKFRTIVENLNDVIYTLDAQSRFTY
VSPSVERVIGYGVNELIGQPFSRFVPAEGIPTLHDWFEKALIDGTKTTELRVLTRDGRIL
DMRTSVRPLRDKGDAAAGLGGLLTDITEYKLLHEELRALAVTDPMTGLYNRRGFTTLAEQ
HMRSSSRTRMKMLLFFCDLDYMKIINDALGHLEGDRAIMDVASILKKTFREADIIARIGG
DEFAILSLNTADISPEYLLKRLQHQFDRHNAEANRSYQLHISIGWAAFDPEDPRTLDDLM
TRADTAMYEQKKVKRL
>A0A7H8VCE4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFVFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSQLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSNQQQKLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A173T610|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MKKYICLFLSTLMFLTVFSPVNCYARDGKKVIRVGFYTLANYQECDENGNYSGYFVDYLR
EISQYTGWEYEFIQMNYSACLKSLNDRNIDLVCGVDYSSFRTSTLDFSAQPAVTTHYELY
ALKDNDTYYYNDYADFDGMSIGVLASCNHLDALDDYAAAHHFSFEKQYFGNTAQLEKALE
DNTVDAIYATNVSHPSEKKILASLPSFPLYFVTFKGNPIMEDLNSAQAVILDVNPNFDHD
LYTTYQQDIRNYRCEFTRDELDYLSTAPEITVTCDPSKAPIEFYNENTQTVSGIAADVLD
LVSQYTGLHFRYIKSDSFSDALAKLQSHEIDILTALAHDYAWSEQNQAFLSTPYLNSSIV
VVRNNKTKSHERNIVALPHSFNLTNSILDNPEYDTEDVVYYDTIEECFQAVLSGSADCTY
ANSYNSSYLLSQVKYRNLSSTTLTAMTEDVSFGLSDQCDPRLLSIINKGLACISSEQLDS
IILQNCSYKEDPSLFTLVYAYPRISIAIILAVSMTLLSLLLGILLIHSRKTKEIRIMSET
DALTGLYNRRAAEDHITRQMQEDGRNPGCVRPLISIDLDKFKQVNDTYGHLEGDALLIAV
ADTLRTSVRSSDIVGRIGGDEFVVYLSNVTDRQNAMAVAEKLCQVIRELSTMKKEWSNIS
ASIGISFADHPNIKMEELYISADKAMYSAKENGRNQYQTL
>A0A8B4TWK0|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIAAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRQEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A2K9P904|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii complex sp. CFNIH2|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRKLASEIAITHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSGEADNIDELIKVQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDGQYDSVEKLQVYHYSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFTLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFYSTSSTAKALNNKASRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRANTSLSVLIIDVDKFKEINDTWGHNTGDDILRRVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEANQTDTLRTAERIRSRVEKTKIKAPDGEIIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A7H4PDS4|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MARHNRKLSFTTPIIIGFAGILFSFLLIAVFATTTQRNDFLEDYHHINRNFTHNMATNYT
ETLLQGNDFILTRAATFFARNDALNEAVNVNPEKGLMQLMQLQNMMQTVSSISLADTNGH
YLRAPEVLETEDSQSFDAKTRPWFIKQAEASTFSRYTSPYNDYFTHHPTITVYKPIISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVILHPDPGALFKPYVSEALMD
RMTSGEGQLYDTNTDTWYYYYSFTNPDWFVIYRVDNSTLVNLTRHETDIVAWSFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAAIFTTGHSDDALMLLESWRARVALRSWREEGLTVTFSAGLGEW
NMEPLEQLVVRVDEALYKAKQQGKNRIVRA
>A0A7H4LUV2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MMNLFANLISHYVEKETLVQQLRAANVALEMHSYTDELTGLPNRRSLFKHLAAQFSQARE
QQRSVLLIFIDLDDFKAINDRFGHPCGDSFLIQIGERLAARVRSGDIVGRLGGDEFFNCR
SGSRFSRPAGVISPRYVKRWRGSISLANTGLNYPAPVLG
>A0A7H5A2I7|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTSLERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A656ILK0|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis (strain 2009K0958)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1Z5HZU2|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MKPVVIAKITGYAALLILYTPVAMAVTAESSEPLYFTMGFFFGSVITAIITCYLSRHFHK
KYQQMLLQLKLAKNNNKIAEQTMKILTEEQQDSQDLLEERVQERTLELNIALQELESANQ
ELERKNVLDELTGLHNRRFYDQKILAEYRRSRRNLTPLSLVLIDIDHFKLVNDNYGHLAG
DQCLIWLSKHIKQSLKRSADKAFRYGGEEFCLILPNTDVEGALLLAEQLRLLLNEQVFIF
QEIEIALTISCGICTYQQEVDIGPEQIFSGADKALYQAKNNGRNQTQQYILTE
>A0A162SJ07|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MDKILLNALNCISEGTIILNDKCQILYWNNYMEYLTGMKLENVLQSNIYDILPTMNKKYF
RDLVKNVVNHECKMFFSAAMHKDLISSNKKLNLKISKMKSENNDYVILEFIDVTNQFLHI
EQLRKYVHDLYLLNKELKEKEKIIEELAYYDKLTKVANRTLFYKYAEKFLYNAKRNNSLL
GLMFIDVNKFKSINDTYGHEIGDKVLIKVASILTEATRKNDVVARYGGDEFLILLPNVKM
IDNYKVIASRITNNKNKIINIDEKQIKISLSIGVSFFPKDGDNIDKLIVEADKAMYIAKK
RAGEDNCFCSL
>A0A8F7V919|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVAGAGIWFGAIYALVM
TLLVLFVLGSLLLWFHTGSFMASADAESLQVLVIWGIALLLFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETDRLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEENMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAEQFLNELENEMMMNEL
>A0A5Y3N217|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLYLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6S6WMU8|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MKDERDLSELIEIIPDAAIVVNQDGMIVLVNQLAAELFGYRHDELLKAPLDNLLPESMRS
QHKFHVASFFNTQQSRPMGRGFRFLGQRKDQSTFNVDIMLSHVEVKQNSYAIAFIRDATQ
ARETEEKIRRQLEHERKQAATDFLTGVANRRAFHQELAQEITEARLRPHKFNVALIDLDN
FKGLNDSLGHEEGDRALQAIANAVCSAVRGSDFVARIGGDEFATIHPGSTLDEGMTILER
ARAQVLKVSAENNWNISISVGICYCASDTPIDHEDYRVETILRLADAAMYKGKRAGKNQI
TTIEFSSIDS
>A0A143QDL6|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MTRRADRRLRPERESHFDTRSKGVIFSAGGALPLLLIAVLEPTFLRPGTLPILVGIVVFT
VVTVGFTVRVGTLTDRQFTVLGSGGMLGVAVCAFLIADPSGARAVTAMLAVVPALAASGS
PRRVTLSLTGAAVILAVALSINGAEGVVRYVAAGAAVTTVIVPALLIAAMRTSLESVTER
LETLANTDPLTGLLNRRGMLPEVEALLARACLTRKAVVVSLVDVDHFKAVNDTRGHAAGD
DVLTTVAEAIARQVPSDAVVARLGGEEFLVLRVAATVTGLEEHILEAVRSSCDVTVSIGV
AQADVRPGSADAVVDVETTLDRLTYAADRALYTAKTSGRDRVAFALEDPVEWPLGGISSR
RDRLEVLRRGAS
>A0A5P2MGW0|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKKQNVIATWRYDAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGDRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQAFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A8F3VL26|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MQRDTFVIKKNLLERLRHHPGQIVNACFLVVLIFSTILTWREVVVLEEAYISSQQNHLQN
VANTLDRQLQYSVNKLLFFRQSMGDALQTPLGFRVLQDAVQNFNTLRAKPFWQLEVEQRR
ALPINGVSDGMVTQTTLLVRDDKRIGRELSAALEVGYLLRLAVSHANNKEKGVTYVSRAG
FFVSTLPAALNTSIISRYYDLVTRPWFTQQTDRGNRARAVRWFMAPFTAGKNERLITASV
PVYQDNYWYGVLAMDFTLPTMTQLLMDAVDQHKDGEYQLYDNRLNLIATSEENTERVTQL
DAQELAQIAHAVESDTQGGLRLSTQFISWERLEHFDGLVLRVHSLKEGVRGDFGSISIAL
ASLWALFTATLLISWLVIRRMVSNMYTLQNSLQWQAWHDPLTRLNNRRALFDRAKALAEE
CRQQQLPFSVIQLDLDHFKSINDRFGHQAGDKVLAHTARLIKHALRNSDVAGRVGGEEFC
VVLPGATAEQAAGVAERIRVSIHRKEILVKKSTTARVSASLGVSSTEENASFDFEQLQSI
ADARLYLAKQQGRNQVVCRGPDKK
>A0A1B7HRS4|diguanylate cyclase|EC 2.7.7.65|Buttiauxella gaviniae ATCC 51604|TrEMBL
MKNIQPLNYDIIKNEWQLLINNTNAATHQTLMSLSDEEVRQLVDAYYQYMLQDEKAKLFL
STTQVEERLSASMNNWLRKVLGSSCEDLSELIAHQRKVGEVHARIGLPIDLVARGARKLK
YELFQLLLNKPQISAKEISDAIFFSGMAIDSAIEVMTIAFTPSHQKMMHDQEHFRLLTVY
DDMNVERERQLGALKDWENQFIYNIATELPFEERVLLSDSEFGLWFAHKGQHIFRQPDLI
KKIDSLIQKIDRIITTEFANESSDAFSRIHLLRMLRQDVEQVNMILSSIFEEIVKSENGK
DPMTKLLTRRFIPTIMGREIGLSIRSGKPFTIALLDIDYFKKINDNYGHAVGDNTLKNIA
TWLHEYVRSSDYVFRYGGEEFMLLLVETTLSQAQVLTERLRNHIASQMIEVDVDTSFNVT
ISAGLVEFDNHPDYQRLINKADQMLYQAKNNGRNCIESYPFGMDNSL
>A0A127MTQ1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MNLPRLTERRSTRRKSLGRLLYRAHLGVALASVCMAGLAVAVVGLLTLRAYAEHNLHLIG
RSMAYTVEAAVVFNDSAAAEEALRLVASTEEVRRCAVYDAQGRLLATWERGHGVSALRHF
VGRWWLNHEEVQPIVHDGRQIGEIRLTGTGGRLLTFLITGLGGMLGCLALTALGAFYLSR
RMVSRIVTPLDRLARVAHAVRRDRQFSRRVPSARIAELDELGGDFNALLDELEAWQQHLE
RENASLAHQANHDSLTHLPNRAFFEGRLSRTLRELAQRGEQAAVLYIDSDRFKAINDELG
HAAGDRVLVAIAERIRGQLRDSDLVARLGGDEFAVLLAPLPDSRAALRVADDILASMAAP
IALPDGSSISTSLSVGVALYPRHGRTLAELLHRADGAMYQAKRRGRGMRSLAGEDTDSNT
EDYKEIARDSQAPET
>A0A170NG70|diguanylate cyclase|EC 2.7.7.65|Clostridium coskatii|TrEMBL
MKQYQLKYENFEKMQHFIYGNNINNSDNILIQIFTAVVEMKFIKDLTDKITSMLPRAEII
GATTAGEIYEGNVLSKTTIISFSIFEKVRIKAKLLSDKNEYKIGVNIVKELSEDDTKVII
LFCDGLITNGYEIIKGIESANNKLIVCGGKAGDNGYLKKTFVFTKEGITENGVAAASLTG
KSLNVTTERSFSWSPIGKLMTITKALNNRIFTIDNIKAIDVYRKYLGDEVAKDLPMSATE
FPLIIKRNGTYVARVAFGCHNDGSLSFLGDVKVNDKVQFGYGNVNMITSQALEMTHRLKN
KNIEAIFIYSCSVRRNFMQNKIGIETSAVNSIAPTFGFFTYGEFFTFNRSNELLNTTMTI
LGISEGNQTFYKNEPTPNSENENSSKSFFEGKDVGVIKVFTNLVNQVTKELQEANNVLEK
QKYKVEQMNNATKAIMEINSHMLSSCEIDSLFEMILCKALDVIPSGTMGSILFMKDDELV
YKATKGYFPDKIKEIGYKLKNLYQYKVHDMNIKELRNPIVISNLEKNLFNEKDKYNSWKK
LFIKDPYQLLTCGICIDGCVKGFIDIFNTDEKESFNEDDKKLLKYLSYDIAIAFKNAQLL
ENILYMSRYDSLTKVYNRSYFNKLLDETLNKARLSDSIFVICIIDLNNLKVINDTYGHIV
GDEVLVKFANILKKEICEEDIFARIGGDEFAVVFVNKDKNSVINIISRVSKIFKDYPFNL
NGDKKEISFAYGLSQFKDDSDDVNELLKIADKRMYEKKKKMKDRRKI
>A0A4U6LSF3|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
MFPNTMNDENFYQKKAVPNEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAEDPLYSEFTNIKADAILAGMWVGIMGANL
LPSTALLMIICINLMGAGGVRLFIAGVVLMVVSCLVTLQLTDIPVVFSSTQLSVLLSLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRQQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PAASAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NAGRNRTEAAA
>A0A127MZ27|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MKPTQWQQDIQQLRHLRLFQNVAGTALQRLLNEFRALELEAGEVLLSPFNRNHFLYLVLE
GQLKVYLGSLDNSPVSTLGSGDCAGEISFIDHDHPSAYVVATEATRVLRLHREALLSLFE
HSPQLMQNLLEMLCARVRQGNRIILNTEQNANIDTLTGLFNRRWLEHVYERESTRCAFNE
QPLAMLMLDVDHFKDYNDRHGHLAGDYALCLVAHTLRSQLRPKDSMARFGGEEFVILLPE
VSLDEARAIGERLRMSLEQIDSFYSPLGALPGVTVSLGVAEMHLQESLQGLLRRADEALY
RAKQHGRNRLCG
>A0A259UBJ0|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MRTENGVEIQISSLKPRRSLLEVVNIDELRDVCEKFTCFTNAVTAILDLEGNIILETGWQ
EICTCFHRIHATTLFRCRESDTILARQLRLGEAFTVYKCKNGLVDVAMPILIRDEHVANF
FIGQFLFEVPDKEFFIRQANEYGFDQSHYLAALSKVPIFSDDYIKQIMEFISSLVRTIGE
TGLIRRMLEETNQRLEQDIIERKREKIALQESEERLRFVLEGSRLGFWDWNLVTGEVNRN
RQWAEMLGYSFEEIQSTMKQWEDSVHPDDRLMAWQSINNHLKGKTPLHELEYRMFAKDGT
YKWIYDRAMVMVRDQEGNPLRMSGTHTDVTDRKNAEERLLYYSNHEPLAGLYNRAYIDVE
LSHAACGRRFPIGIIVGDLDNLKAVNDILGHAVGDWLIKSAGEIIKKVCRAEDVVARTGG
DEYVIILYEIEAAAFSAVVERIRAEAKRFNQKQTGPTVEISFGAALAISDKELKETLKRA
DDAMYSDKRLRKNLNNS
>A0A7U8X5N9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli FVEC1302|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A174L9Q6|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSIIAYLQRLANGVSTAELDVAALPTELCAIGEQLQKTFAILQQERELLER
GAYIDSLTNLGNRAGLHRYAELLWHKGTPFTCAYIDIDRLKHCNDTFGHTEGNRYILSIC
RALTETMEPNDLLFRIGGDEFVLVSPTTDEAELEQRLERTRTDLIEATSGGKAPMIASFS
FGCSRVDPLAGDTRRQMTMDADRKMYRYKLMHRVQQPKENDASMRPIADQPPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSINAVRDFDLPSQHPYNSLDMWLARVHPEDRDNVRSEL
DMVVNGAWHFHYMQYRVMNTAGKYALCECTGYRLDSTETEPNMYVGIIINRSLADTTDSV
TGLGDIHALVNAIGEMRRVARKAGLVAIKIDDIAKVNARFGFDAGDRVLAESAACLMDCS
RGKGRLFRSTGPMFVALFDDLDPEETDAIAEEIERFLGSPVLFGSFEYQPPIRVATLHLD
AVDRQPVSILNELKALLEEAPQVPGTKLD
>A0A168FXF1|diguanylate cyclase|EC 2.7.7.65|Isoptericola dokdonensis DS-3|TrEMBL
MHDEISQVARHRQLRGGVRLAGVVSDLAQPLTVVGSSMPVGQLEVMFRNPEVTCVVVEDE
ESDRVGMVMRAGLAAALTGRLGYGRAVLERRPVATVTHWEPMVVRPDEAVSAVATRAMER
TEEHRYDDVLVAGPTWAGAGTADLMRSLVAALAERSSVDPQTRLPARAATWHSLGRRCEL
VRGGGTRVVVVLLDVAGMSRLNARHGLATGDAVLTELGARLRDDLPRGCEAGRVDGDRFA
VLAILPPMDDVHAAASADQLRRYVLARVMEPPAHLDALVWPDLRSSVVWSAEGSGDPERL
VREAEARLATGDDLTVRAGAGEVAKRSPAGTPPPPPPPPAPPTREADRSFSDSVRVEGPP
AGAPSLPSRRAR
>A0A142YEJ6|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL62|TrEMBL
MQSEKGWRRDAPTSTLATREGEEMDAGRRERAEVEAAVHDFATAASSSTDLVALCDALAT
AARRVAGGAPIAVHLAGEAVEPASGATALPLRVGESGKTWGWLVLDGPGADPEPPSEIMG
RRLESLATLAAFAIERHRAGRLASPSARSGPNVAPSALHDVGLLGTVLPFALSQARRHKE
PLSILVVAIGRLRGVRDLLGDSEADRVVSRIGIGIVGLLRSSDLVARLDGDRLMVVLPRS
ELNDARRVGEKLCQGIAAAHDLMGIPLKASLSIGAATFPTSASTLGELFDAADAALAEAC
ELGPGRVAAAFDRGREVASRC
>A0A1C5VNB4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSATRQQMLETAERLNQQMTDGIPFTWETLEQALTSVTEQDDKGIHGWICYFAAFYQLTT
GNQEGCLHYLDESVRCLLGTDLEHHVARVYNMIGIVAHMQNNLSLAMEQYDKALDYTEKY
DDKMVHSIVLSNMSDAYYLIGAYERAVQCHAECIREFEQADDNSTYSRINFRKMLAEYGC
CLLHLHMDDEAEKVLCKLEETGQSEEVIRETRLGVNVFLAHLAERNGDRKKAEEHVRTAV
MALEDMTQVSSEYDSIQNLLQYVEKIGKPEQIEEVLNCLEPKAAIEQNKSLLLQLLSLRM
RYCSSRMTPEEFKQSADTFFHLKDSWELTENSQVMYMMELRKRLQTAEEEQKEQERKRNR
LLYQADHDELTGLYNKRSLNRYLEDVFEDCLLNEKELGILFLDIDHFKQLNDRYGHGRGD
EGICAVADTLKKCFPEDYVARYGGDEFLVVMTGRDREYAEEHARQLCMGIRECEIPNEDS
SVEPWLTISVGGVCAIPKEPNRVWDFLSAADKTLYDQKNEQKGKVRFYVGEGQYL
>A0A1C5ZKI5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKTIEEAKNICRTIWHLYLEQRDYKTLATFVDQEMTLIGTGAHEICHTSAECFQKLYQEE
EQWDGSFLITREWYQGYACDAHTFNIIGELHTKENGKNRIIYEVTTRFTMLLHYKNEQWK
VLHVHQSVGDHNQMDNEFFPKHIVDQSNRMLKERIAQKTKELEERNQQVLYYSQYDYLTD
IWNRQYCEKQIEQTMAKHAYGIMLMIDVDHFKWFNDSYGHPFGDKVLKTLAYCMKTVFFQ
GLCGRIGGDEFVVYGTNCEGDITCVEDKINSFFTYWKQAQKALDIAQTITLSVGVAYYPI
HGTNFDKVWQHADKAMYEAKKHSDNTICFYDTKH
>A0A1C5XCS9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDNGISANDFCRNIWKLYLEERRYDLVGDYISDRISVIGTGAHEVERNLDEFLGTIEQES
REWNGRFTIQDQWYQTTELSDKHSFVMGELIVRENAPDGILYDMRFRFTVVLERSEHEWK
VLHIHQSVPDPNQTRDEFFPHHMVEQTHTQIIYNLRHDSLTGLLNRLYFKETCERFLASG
DSGAFLMMDLDCFKQVNDQYGHPDGDKVLISFSESLKAICFSTALAGRMGGDEFAVFLSG
FNQKTEVETFFDRLKKDWQERQIVLPMKNPLSVSVGVVFSGTGETSCDSLLNKADQALYE
SKKEKGTELIHWVFYTADGVSSF
>A0A1C5PY33|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MYLSLAVVPETWYNRYMKKKKLTFLAFVIIAIALLLEVGILKFVNDNNTYQMSKVLLDRV
VTVLNKNNENENGLIESLKDDYIIRAKAASYIIDAKPTAEHDVEELQKIANLISVDEIHL
IDKNGYIYSGSMPKYYGYNFDSGEQMSYFKPMLTDKDLTMCQDVTPNTAEKKEMMYAITW
NEAGTRMIQIGIAPKRLLEELKQNEISNVVSDMPLYKGIEIFVADAKTKIIKGATDRIWI
GKTLDASGIATDKINNSKTVSFHTKVNGKLFQCFLCHDDTYMIAIAVDNSFYLKNSIFAI
LIVGIYLVFASCCMVYMLSRVLKEKYEKEKLLYTSNTDELTKCFNRHAYETAIHGLDLHK
EWIYISMDINGLKCVNDSLGHAAGDELICAAADCMKECFQNYGNVYRIGGDEFVIIMTEK
TEELQKIIKDFEQKSALWHGELVDSISVSYGYVFSSEKAWNGIYDIAKAADERMYKSKSC
YYRESGLDRRR
>A0A6I2JG03|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT702|TrEMBL
MTLEILTSRERPHRIWLNALLIGGLTFLLTLFCLELIVVSGRISPLWYSTALMTVIVFRA
HSRHVPLLLFACVMGTALANLIIIGPALSNIKFAILNMVQAILGGVMLRALLDRRAPLNS
LLDWVRFALCAGLIAPLLGGVVALWMLHVGSSASLPFFSTWVISEVIGVLAFGPVLLLWP
NKPLRQIFTPGRQLETCLTLLGTLLASYLSLRFLPWPFTFIVVILFWCAVRLPKFEAFLL
FFLNASFISILLAFNLVNLAQNGMLLGQVSTWLPFLLVLLPSHVMALVMDAFQREKHHIS
ESETRFRNAMEYSAIGMALVAPNGGWQQVNQSLCQTLGFPADELKKLTFQQITHPDDLNS
DLQQLERLVAGEIMTYTMEKRYFRKDGEIVWARLTVSMVRDAAQQPHYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYELFGLGPHQTPTYDLWVHL
LDPAERETAALVVQQAIERRSAFQLEYRINLPEGPRYVRSEANRILSQDGQIERMLGICQ
DITPLRALNEALFQEKERMAITLDSIGEAVISTDDEMRVTFMNPVAETLSGWPQEKAAGV
PITELLNITRGASGPRVDNLLLCQLPGEKISPDLDEELVLHTPDGTRVEIHYSITPLKTL
TGASIGAVMVIQDVSESRKVMKRLSYSASHDMLTRLPNRHSFEQRLKQLVNDAAANNSHH
VLVFIDLDKFKAVNDTAGHAAGDALLRELAELMPHHLRSSDMLARLGGDEFGVLLPNCEV
DQVRDVVQRIVTAVSEYRFMWQDQPYHVGASAGITQIDQRNCISNVVMSQADVACYSAKH
AGRGQYHVYQEVQM
>A0A1C5N1D5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKRDAESKQHKKWRTVSTIIQSCLIVILIVLVGMMMFEIEHLQGTARVINYAGLVRGATQ
REMKLEMSGCQNDELIQYLDDILSGLKYEDGNYDLISLDDKEYQKKLDEQIHYWADLKEE
IQKVRDVGYQMTNIVDMSEKYFHLADETVSAAENYSEKMAKDIRVLEIVSAIDMFILFCI
VLEQMISGVRIAKKNKILEQRAYLDVHTGLPNKSRCEELLHDMRLITEPVACVMFDLNNL
KKANDTMGHSAGDQLIANFARILRNVVPAKDFVGRYGGDEFIAVIYDTDKEHVQEILNQL
QEEVDQFNMNRKSIPISFAQGCGISTDYKECTLRNLFDKADYYMYENKQKTKAGRKDII
>E9T8U7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 117-3|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A245ZL47|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MHGHSFAKLGPVGRALHWLFEPGGEVDAKGRALLLGQLLNSTAAAIMGSFCSLVVAGAAL
IRSGQTVFAIFCLIELVVLVARLLEWRTRVARSRANPDYLPSIDGSAVLSVIWCATQGTL
ALTAMVSGDLVLSVLSTTLLVAMLGPVCARNYPAPRFAFLLVLLCDLPFVAGAALSGEPW
LLVILILTPPFLLGAMQIIRTFHRSMLLMIAAEKQALYLAEHDALTGILNRHGMDDALGR
IAPDAHRCMALLSIDLDGFKQVNDTHGHGAGDVLLMKVADRLAQQLGPDDLLARMGGDEF
MVVARGVAADRAAPLVDRLIEAVADTPYDVSDDCKVHVGASIGFACLPEDAASTVELRKR
ADLALYAAKGAGKGVGQRYRPQLDTARTPARAASSRGGRR
>A0A0S4ICI6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MKGHRTQEAPKLLGLTWPFIAVVVFQVALGSLSLYTLSAVRAYVAGESLWSKAQKDAIYY
LNLYATTRDEATYGRYQQAIVVPQGDHRARKLMDQSNLDLEAVRQAVLQGGNHPDDVQRI
IWFYRHFRTVSYLQTAINYWDIGDDYLAKLNVLAGEMHQRFASGPVDEQVIRAWKSRIAT
INEGVTPAAKAFSDALGEGSRVLLRVLLITNLLTAMILITIAWRRSSKLLAQRQAFANAL
QEEKERAQITLQAIGDAVITTDVEGLIGYMNPAAEQLTHWKAAQALGLPLSALFTLVDEH
DVDEGRSLVEQVLSGSLKGGAEHARLIQRLDGSTVSINLVGSSIVNDGQVNGIVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQALNALARQPGRHSLMFLDLDQFKLVN
DTCGHAAGDELLRHICAVLQSGLREGDTLARLGGDEFGVLLENCPSEQAERIAEQLRQTV
QSLHFVWKGRPFVTTVSIGLVHIAQAPGTLEASLRAADMACYMAKEKGRNRVQVYHADDS
ELSIRFGEMAWIQRLHVALEENRFCLYAQEIAPLKAFEGPGHIEILLRLHDESGRTILPN
SFIPAAERYGLITALDRWVVRNVFIIIRQCLDAGHQGPLSTCAINLSGASIGDDKFLEYL
QRLFAEYAIPPRMICFEITETSAIANLGSAIRFINELKGLGCRFSLDDFCAGMSSFAYLK
HLPVDFLKIDGSFVKDMLDDPVNRAMVEVINHIGHVMGKRTIAEFVETPMIEQALQEIGV
DYAQGYLIERPQVFTCDSLHRQRIAARPLLQRAPGTFR
>A0A3P6KWK6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTARSVS
>A0A403A517|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQMIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVLGGPIVAHILSSHYESYDLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETRRNKVVVRDVVNFCESP
>A0A2S8D5T8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
MFGYCISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKAS
ISPVYDVLAHLQNLVMTFSDITEERQIRQLEGNILATMCSSPPFHEMGEIICRNIESVLN
ESHVSLFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAF
IERVADISQHMATLALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVY
LIGVDHIQDVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNI
TQIADELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAIDYIRKNGGNGW
QFFSPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHG
HVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLP
NQVSDAMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSFLFPPPTRRRNS
RLDEQRVTAENLTNSSRPHSRVFI
>A0A1S8TBD3|diguanylate cyclase|EC 2.7.7.65|Clostridium puniceum|TrEMBL
MKFPNKQIRNTTSFKENNLEYIEMHKLLLENAVECIWLYDLAKKCFKYISPSIINLTGLT
VEETMKEKLENSLTPQSLEKISKTIPKRLFRFLNGDRSQKVIWDINELQQYCKDGTIKTI
ETSTKFILNENTNYVDILGVSRDITERKKIELNLKNEINEKNEVIENMRKSEKRLSILMQ
KLIKKNNKLRNIAIKDKLTGLYNRYFFEENMVKKIEKIDFSNIPLTLIIFDLDRFKNIND
IYGHYEGDRILKKVANTCIKLMSKYDIFTRWGGDEFVILVLQTDLDKVSILAEKLRCSIE
TTLNKDLGQVTLSLGIAERSDSESFKSWFKRADMALYQAKNNGGNCVVIG
>A0A2X2K8B3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEGLTRKQE
ESSHDPTRSGHSTTAFEFPRF
>A0A809MN69|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MKLPIDTFVLRWKETCAPYSSDILALAHERVDRQAHELADAFYESMLADEAAAYFLSDQL
VHQKLHASLQAWLRSVFGAAVHHDYEAAVAFQQRVGQVHARLDIPIHLVMQGTRTLIRRM
RATLADDTSVADALRWPLSSYLGEIMLFAIELMSLAYASSHDRNARAEEGYRLLSLSQNI
GTEKERQRAALLDWENQLLFGLSVGDSAQSLPRLRKSEFGLWFIHKAEHAFEGAKEAEDA
RAQIEAVDRLLDEHPAPPDRIRLLHAVRDATKTIAYLLDVLFEKANHLESGRDTLTHLLN
RKFLHVVMSKEVAYARKTGSPLAVLMVDIDYFKNVNDEHGHDAGDFVLQQVATLISTYSR
GGDYTFRLGGEEFLVVLVDANADQARHVAENLRQRLAGRMLALPDGSQRRVTMSVGVAAH
DGHPDYQRLLKRADGALYAAKARGRNTCVLAD
>A0A1M6BF47|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MRHPFLLKQWTVIIFLFILGCAYTGLIEFLFLTHRQAMRHDIQQRAEEELSLIRYKLEAS
ILADAYAAKSLSMLISVHSRSIQQFWENVSRQTIEQGKFIRSVAFAPDDVIRYVYPLQGS
NKVIGTDFHQLPDQWKSVRKSRLLQEVVVSGPVFLVQGGRAVIVRSPVFLDPPENQHYWG
GVSIVVDIDKLFNFLNFTHLASHFDIAVSGQDFTEKKADVFWGNPEVFQHIFVQEMFYFP
SGTWQIAVAEKPGSILSRYTWYQYYLVRLIGYSLFIVLAISFLTIYLLYKRSSRLSMCDE
LTQLPNRRFFMDRLSKVFEGKKQRGRCSGPGFGLLCIDIDKFKLINDQYGHLVGDQVLIE
CARRIRHVVRDNDCVARIGGDEFLVLLADSGHSLYIRSVIEKIRHTFERASIDCEGHRIH
VEVSIGYTAYMEEMNNVGDMIRYADSNMYAEKYQR
>A0A0H4W166|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MLAPSNLLLITALAALIGLCVLGSLWRSGMAGIREAMGANVATIVAMLIMVQQASAPPWL
GVLLSNLLFTLGGILFVAGARRFLGQPVPWRAMLGGVAVLIPALAYYTYASPNVSVRIVL
ASLMYTSLLALLAWSVWRSRRQRFAYSQIFMLSLALVAVLGHGTRMTVYALGVDVIPGLL
APTFWNIVFLSLGVVIMPSLTLGMIMMIHDRMLIEREREANTDFLTGVLSRKAWWQGAQQ
LGARARAGRPLALLILDIDHFKQVNDTMGHAAGDAVLRHFAAVASAALRPGDALGRLGGE
EFIAALPGASAHEAQALAARMLAALEAMPCQYGDTQLRYTFSGGVTSWDGAEALQSAVQR
ADQALYRAKAGGRSRVDLARQA
>A0A1V5IQ00|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MAFRDKKRKKQKAERGEAELLRALLRLANQLQSNLALDAVVHVIATALSDTFGFREASVY
LREDADEFAVHATVGEFPDYDRVLFERPVPRRIWDELFLEKHRIGSSYFVDHRRHEWTEE
QLHYLPELDLGPRRDDEWGSGDDLFVPLYGKEREMVGVLDLFDPADRRLPTLDLVESLEV
FAAHAAAAVENARRYEALEETSTQLEGQLALQHAILEVSGDLLAALEPRGVFARLAMLLK
EIVDFDSLEVRLVDEKAGELYSGYSVDEVDGEAVRSWRTPVDTGVSGWVVRHNEAQLVND
MLNDPRGALVPGTEWEPQASIIAPLSLGGDVLGVLALDRMGGRTFEAHELDPVALFANLA
AIALHNARQYEQAAQAAKLLEEQLALSHVLLSASGAVLSSLEQTEVLEHIADTLKQIVDY
DTMDIRLVDPERGQLVAIYARDEDDEQEIFAFPIPIEEGISGWVVRHNEAQLVNDMTNDP
RAVHIPGTEQDEVQACILVPLSVGDEVIGIMTMDRLGGRTFEQHELEPAKLFGNLAALAI
RNARQYDALETTSARLEGQLALQHELMSLSTLLLSSLDQKDVFSRISTMLKEIVDYDAMD
IRLLDEATRELVCIYSRDVNAELNEQFRLSIDEGLAGWVVRHDRAQLVNDMATDPRGVHI
PGTGENVPQASIVVPLRVLGKVTGVLTIDRLGGRVFAESDLEPVTLFANLAAIAIQNART
YEEMENQAIRDGLTGIHNFRHFHESLKAEVSRAGRYGDHFCLLMMDLDHFKAVNDTVGHQ
KGDEVLKAVAGVLRECSRESDYLARYGGEEFAMILPRTTLVEATTLAERIRTSVALLDFG
HPGLRVTMSIGVSAYPESARDSDGVLGAADAALLRAKNSGRDRVCLYTDAAVDATAELEG
DLAALGRRFAAFLGLDEAETAGLVTALAVYETGAAVQDEVQTILGGGEAAAAAADEVREK
AVDALVYGNERWDGQGYPEGRRGSEIPRVARAFAVCRRWQPSAHNGDAVEDLRGRAAHEL
DPKMVQRFAAMLRAEKAPQN
>A0A0D0TK00|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPMQAVRPKILGFISEQASAWLVALVVLLAGSALTVIVAWAAADLYQQQVRQRFQLLVNE
RYTRIQERFEDQEQRLGSLQRFFVNSGDVSRAEFDGFAQPLLLNARAYAWAPRIFREQRS
LFEQDISRQRGVPFSIRELNTVGELARAAERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RSVLERAQHSGKLAVSQPMQLVGVEPAYAAGVLLVAPVSKVADTEPYGFVMAVISMRQLV
ADGLPRSNRDNLVMQIVDTSDTQQRVLYESSNAVGDSDLRAARRLVLGDHVYALSLRASE
IFDKSNHSSMRAILAMGVLLSALLSALLYVLVSQRQRALKLVEQRTVQLRAREQELRGAH
GQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGLKAEEVLGHLTLESLHVGVELEAR
AGLLSLALGKRIPPSQAMLVESPDSQHEAREWTLVRKDGSQLTVNMLATVLLDDYGLWVG
YLAIYLDVTQQKRAYEALAARDRLLKKLSAHVPGGIFQFTHEPQDNWRFIYASEGMRDIY
EIELSVLQQDAGRVFERIHPLDAERVRASIRLSALQLSHWREEYRVQLPQRGLRWIRGEA
TPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIYNRRYFQDRLKGEVLRLNR
NCGALSLIMLDIDHFKRINDQHGHGVGDAVLQELCKRIGQRVRRTDVFCRLGGEEFAVLC
PNTDGTQAYSLATQLWQSLRDTSMEPVGIVTASFGVASWRIDEDIDGLLLRADSAVYVAK
QAGRDRVEACGSGQALMPDGL
>A0A5E7J990|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGRKGLSLARRLYTSRVLGLLLGLLCVSVSMYSLDPPLWVWALMFSNGLVWPHLAYQ
LARRARVPFHAEHRNLLIDAFFGGFWVAAMHFNPLPTATTISMMAMNNVAIGGARFLLAG
SAAQLLGVGVGLVVFVPAFIPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGVHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCIRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFATLGYEQNPA
LQVSLSIGLAAYDPAHPDATRWLSEADQALYEAKASGRNRVICHCDSLPKQPLLDSV
>A0A1T2ZIS7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAAGGNGLPLASRLYKSRLLGLTLGLVCVVFGMYPLHPPAWVWVWMVINAFVWPHLAYQ
WSRRASNSLRSERRNLLFDSFCGGFWVGAMHFNPLPGVTTLSMMTMNNVAIGGFRFMLAG
WVAQALGIGASMLLLGPAFIAVTTETQLYACLPILTLYPMALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLEIEFQRCRREQVGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRASDMAGRYGGDEFCVILPDMPLARATEVMDALRDRFSALAYVQDPT
LRASLSIGLAPYQAAHADSTSWLNDADQALYEAKSSGRNRVSAVQGSWLRSV
>A0A5E6TEF7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLDPPLWVWALMLFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGLRFLLAG
SAAQLLGVGVGLVVFAPAFIPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFAILGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKAGGRNRVICNCDGKPRRTLLDSV
>A0A5E7NEN9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRLFRSNTRPTLGSVLGRGHLTVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKAAATESLAMIASAEEVADAQVLDARGQLLARWQRPETGLISELEMQLAR
AILEKPIDLPITHQNREIGRVLLTGHGGSLMRFLLSGLAGILLCTAISAWVAIYLARRQL
REIIGPLRSLATVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAYFEGRLIPALRNAGKLKERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVADRVRAQLREGDLVARLGGDEFAVLLAPLHKVEDAERIADKILASMDLPIAL
PGDGSVVTSLSIGIAVYPDHGVTPGALLNAADAAMYQAKRLSRGAQSMAGSEHPVSPVQT
RS
>A0A379IB85|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKQKRTLGTPRLLGIVWPFIAVVLLQALLGCVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LTLYADNRDQATFLKYQNAIAVPQGGHELRVALDRPSPDLEAARLGILKGGNHPDDVSSL
IWLYLNFRHFSYLEKAIELWTVGDGYLVQLDDLAQEMHRAIIANQVSSADIHAWKERIIA
INDGVTPAAKAFSDALGEGSRMILRLLVTTNLATALGLIALALLRTRKLLAQRHAFADAL
QLEKERAQITLESIGDGVITTDVDGAIAYMNPAAESLTHWNAAQAQGLPLAALFNLLDEH
AQADGFTLIEHILGGQLSGGSEHSKLIQRLDGSTVSVTLVGAPIRSAGKVSGAVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQVLHGVGRQQSGRHALMFLDLDQFKLV
NDTCGHAAGDELLRHICALLQSDLREGDTLARLGGMSSAFCWKTARRRWPKKSPRACDIP
CKTCTSSGKADRLSPRSVLAWCISRTPRPPWKLHCVPQIWPATWPRRKVATGCRSITPMT
LNCPCALAKWPGSNACTWLWKRTVFACMPRKLPPWATRRWVPGISKFCCACTMRQGGSSC
LTALSRPPNAMA
>A0A379IEK4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLHIPTLLMVAVFVFCLMGLLTVHAWHRVREPTLGYLGVMLLLASLGTALIVVRGVGVDF
VALVLGNVVLLLSAAMNWTAMRLFVHGKPHLPGILAGPLIWLLMCLIPQFYGSMSSRVSL
YSLLAASYGVLSALELWRHRQHLEVAYLPAMGLMLFHTTFYCVRAVIDPGLPLKNANVLM
GEGVPFFSFMLFESMLYAIGIAYVTLAMVKERAELNFKAAAFSDVLTGIGNRRAFMLHGE
QLLADSKQRGRSVALLLCDLDYFKRLNDSFGHPMGDQALIAFSQVTSSVLRKHDLFARIG
GEEFACLLADTDEQGAVQVAERIRQRFAELDLLEPGFLSVSIGVVTTTPACHDLSRLLSQ
ADQALYRAKEQGRNRVQTACNTLQAIAPLRWSE
>A0A174A6Y5|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKKKKIIILSIMIIVVALLLEASILKYVNDKNAHRTSKVLLDRVITVLDKNDESRNELIE
SLKDDYIVRAKAVSYMIDADPAVEYDVNELQKIAKLMAVDEIHLFDDQGTIYSGSAPKYF
GYNFDSGAQMEYFKPMLKNKSLTMCQDVTPNTAEGKKMMYAITWNEDGTKMIQVGIEPKR
LLNEIKQNNISNVVARMPVYKGIEIIVADADTQVIEGATDSSKLGKKLEDVGISANPDSD
DGATVTQIRMDGKHCRCMMRQNDNYIVFVTVEDSFYQQGGMIAIFIVGAYLVLASCCITY
MFSKVMKERLEKEKLIYTSNTDELTRCLNRHAYENDMKKLNLSEEWVYISVDLNGLKRAN
DSYGHMAGDELICAAADCMRDSFHEYGKVYRIGGDEFAVIITENPNQVEELIHSFDSNVA
NWHGKFVDSMTVSYGWVFSTERNWGSAYEISKAADARMYQSKERYYKESGADRR
>A0A5E7A591|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDQILSLLSDTIPKAKTLEQLTRPLLTLLSQVTGMESTYLTTIDTDEGVQRIEFARNVGD
MVIPEGLVVPWADTLCKRALDENRMYSDNVAECWGDSEAAAALGIRTYVSAPIKAQDGQL
LGTVCAASSDQVARAPDVEPLLMLLSGLLGYSLERERLVEQLQTANAELTSLALTDPLTG
LSNRRAILNDAARLFALAQREHKYILIGVIDLDGFKLINDTRGHQAGDQLLRGVAAQLQH
GLRTSDIIGRTGGDEFIVIALGTPSQHSDPETDRRHAAELLQDRLSKATIGRYELGHGLD
AIEYSGASVGVVAVTPGSMTVDEATKLADHEMYKVKQQRNRQRF
>A0A5E7VKZ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLDPAPWVWVLMLLNGILWPHVAYQ
WARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQMLGGGIGWLIFRPLFIPQTTPLQLYACLPLLCLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQHRGGAVALIDIDHFKSINDTYGHVAGDI
VLRQLSKILKQNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFNPAHTDATFWLNDADRALYEAKSTGRNRVICCGDGRPRHELLDPV
>A0A0B7DGC6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENQRGKGLSFSRRIYLPRAIGLGVGFFSVAAALYPLSTPTWLWALLVFNGFFWPHVAYQ
MSTHSAFPYQAERRNLLYDSLCGGFWVACFQFNPLATVTVLSMMTMNNVAAGGRRLFVFG
ALAQVAGVLLGAMLLGFKFNPIMTQIQVLACLPMLTLYPLALGMVCYQLAIKLAQHKRAL
SALSRTDSLTGLLNHGAWKDVLHLKFQQCHQHNSQAIVALIDIDHFKVINDSYGHIVGDA
VLQQLSRELKRLLVENEPAGRYGGDEFCVILPNLPLYKAEALMEQLRQALDQYRHPDVPQ
LRVSLSIGLAQFQPSYCDAIVWLDAADKALYTAKHAGRNTIGVAMSDPASNDASLLGI
>A0A120FWC5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLSVLKPHRWKLALLLIAANLGLILHLACGELKSISEWVWLDIIGEGGSALLALIWLGLV
LKSRPAGRVTQYLALGLSCIFFSWWIDSLDEFIRLPDSISWDHWLESGPMPVGMILLTIG
IYHWHHEQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLADSLRDSQEQQQPLSL
LALDLDNFAAINQAYGHAEGDAVLQAVSHVLLLNLRRQDLLCRLAGDRFVVLLPNTGERQ
AQGLALELQHAVQSLAHKTRQQGERLQLAATTAVVMALQESPHELLKRLNIGLARAKQPL
AKSA
>A0A172YSH0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. NCu2D-2|TrEMBL
MNNECMAMLAEQWKHICQNYSSDDLLHAFQFIQEHSLVLVEEFYKKMLVEKESAEFFSDD
IIQQRLRDTLNQWLLESFSVGINKSYSDAVEKQRMVGHVHARVGIPSWLIMRGVREIERK
MFELLNNSDTKSALTTCSYIIQIMGFATEIMCRSYEAKTVANQEVKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFTGNVGFKHPMLSKSEFGLWFIHKASYAFSGSDQVKLIID
RIYEVDKLNEIVTQCYEKEQILELIQSIRDLNREIQHLVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIVSREITYSRQNRTPLSLLAIDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVATDLERAVNIAESIRKYVEHGMITSAQGQQFKFTVSIGCAL
YDGHPDYQKFLDTADTALYAAKNTGRNRVYIAKTDPQASLSNS
>A0A1V6IUW4|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MQNIFSELKTDSRFIRFVMKVGSPSPMDPDEQHRRIPAVFVLMIISVATAVSGIYHCSSG
KNPLVVLDVIGFILSLIMLLYLRQGKNPGIAYGMISTGFVLLCCAATVLGRTEMSLIFWA
LVLPAGCFSILGRKMGMFVAAFFFFINLLLMNLPEHMILSKPFPASVAARFSVVYLILTF
MLYYYESSHQMLIRYIRHEENKFQNASRYDPLTGLSNRRDILEKMENERERHSRLEKTFT
LIMGDIDNFKMLNDTLGHEAGDYVLQTIGRILKNQVRGIDCSSRWGDDEFLILLVDTDLE
GGQRVAERIRKKVENTSFQYQGKGLAVTMTFGLSIYQSADEQIDACVRRSDDALEEGKRQ
GKNRVVPV
>A0A1V6IVL6|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MTIAVKQQSGKKSINKRKVLQNDLSILARDIIANAGVGMYIVQDGKFVYVSELYQKITGF
TEEELIGTYPLDNIHPDDMKTVREKAIKCLKEGNCNPYEYRFITKSGEIIWVLEAVTSIS
FKGERAALGSFINITERKLIEKKLHHEEQLFRTLTDQSSDIIAIIDRKGVITYENKAIEP
VLGLKVDEQMGGKGFDNLHPDDVPFVSNELKRLFADPDASASRSEVRLRHKNGQWLVFEF
MASGLVNNNVVEAVMINLRDITERKRAEESLRFSEEKYRTILENIQEGYFEVDLAGNLTF
YNDPVCEIMGYTREELMSMNYKKYTGNEMAVKVYQAFNKVYLSGNSTKEIDWQIIRKDGA
RRYIEASVSLQKDFSGHPKGFKGIIRDITERKEMDQKLNHLATHDALTGLPNRILFMDRL
QVALVQSRRNRNKLAVMMLDLDHFKDVNDTLGHLAGDKLLQEVGNRLTDILRHNDTVARL
GGDEFVVLLSDLERMEYAAGVAKVILKAFGKPFLLADHEITPNVSIGIAFFPDDCDDVES
LLQKSDMAMYSVKTHGRNSYKFYSHIAS
>A0A0F3RH13|diguanylate cyclase|EC 2.7.7.65|Rickettsia argasii T170-B|TrEMBL
MTTILVVDDIEPNIKLLTAKLLKEYYTVLTANSGKKALAILKKGKIDIILLDVMMPEMDG
FEVCKTIKTDPETTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSR
MKSLIDELKLRNSTNALLGVTNIAIHDTCVDKKILLINDDVVQAKNIKQILLKLTQNVKV
ISNSDELDIINEYTPDLVIISSTLENDDPLRISVILRGKAEISGVVIILQIDEDGMPLVV
KGIELGINDYFVYPIEESELLARIRTQLRRKQYQDNLRNDLEQSVNLAAKDGLTGLFNRR
YFDIHLKQMIEKTNKESIKLYLLMCDIDNFKHINDTYGHQAGDKVLTIVSHILKNTLRVT
DLIARFGGEEFTILLTDIDISKAIETAERVRVKIEYMNFHIEDQIEPLKTTISIGVTKYK
KEESIESFIERADKAMYEAKTTGKNKVVKL
>A0A6M5D245|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. MUSA4|TrEMBL
MRQNSVVKQPKSFITLKRYFLPARVVNLCFLIVMVCSTILTWREVIVLQGAYVASQRSEL
ENVSNALDMQMQSGVDRLLFFRNGMQAALQTPLGFKVLNNVQQEFGLRRTQPQWEIGIDN
TRTLPIYGVSDYFVNQSDLLNRDDERLPDELTAAMELGYLFRLSANASMLPRQAYYVSRA
GFYLSTNPVESEDQIVPTYYRLLMRPWFRGQQQQQNRARGVRWYTDQARQGSVTRGFVAA
SVPLDYQRYWYGVLVLSFPVSNINRLLVKAREDQEGGQYLLYDSSFNLLTSTLTEQGAAP
VFSAKERNQLLADMERDTVGGRNLGSRYVSWQKLKQFGGVLVRIHTLREGITGDFGRISI
ALSLLWLLFTGMLLFSWGIIRRMVNNMYSMQNTLQWQAWFDPLTRLYNRGSFFERAKTLS
EQARVENLPFAVIQLDLDHFKSVNDRFGHQAGDLVLSHAAGIISNTIGGQDVAGRVGGEE
FCILLPGSTLEQAARVAERIRVRIRGKEILVQKDTTLRITVSLGVSDASEHGDYNFESLQ
SVADSRLYRAKNNGRNQVCSTDGAPKK
>A0A7U8Q3Z7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter radioresistens SH164|TrEMBL
MNEQCITMLAEQWKDICGQYSATDLNYTAQFIQDNSFLLVDEFYKNMMQEKEASYFLSDE
IVQSRLKTTLNQWLLDCFNMPFKQNYEEVVQRQLVIGNVHARIGIPSWLIMRGIREIEKK
VFSLQASRTQQNIYAVTNYIVQSIGFASEIMCRSYEANIEINNDIKHTYRLFSAMQDVSI
QKDKQRSSLLDWENELMFKVFSDSASFNHLLLSKSEFGLWFIHKAAYAFSGTDQVQIIID
RIYEVDKLNLAVLESQDKANAIALIQRIREKNREIQHLVDQLFQVSEYIGSGNDSLTQLL
NRRYLNTIINREINFSRKNGSPLTLLAIDADHFKGINDKFGHAAGDLALQFLAEVLLECT
KGSDYAFRIGGEEFLLLLVDSDLSRAQSVAENIRMRIEETVIRSTMGVSFNFTVSVGAVL
YDGHPDYQRFLDAADSALYAAKNNGRNNVYMG
>A0A517ZLZ7|diguanylate cyclase|EC 2.7.7.65|Symmachiella dynata|TrEMBL
MPSTIEILNRLKSWPLWMAVFAALALAAVVGWVDYTVGDAFDLSLLYVPIIAIVCWVVNL
RAAVMFAVLCSLIWLMDDWIVSGIALHGAEVYWESAVRFLLFVAFAVVLTHLQTALQRES
ALARNDPLTGLANLTSFVEEAERASHHSRRGQTPITVIFLDCDHFKEVNDQFGHPQGDAL
LKDVADCIRSSIRRGDVAARMGGDEFAILCPGMDESLARQIAERVKGDLDRKMQSGNWPV
TFSIGVATFPIAPPSVADLIRESDNLMYAVKHDTRDGVRFKTVSNVSDVA
>A0A5X5PMN8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Offa|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1A5X3D1|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia tropica|TrEMBL
MQRSAQDSANRTPVRVLSSMIMKRPHLVVTLCFGVAMLLVALVGLRQLYNMTRYDLQSRL
RDLQVRAVGVDALIEAERRRLTFLRNYAEHVLAAAPEARGSMLDPAVQRALQASTQVAWQ
TTGEVNGPPVFGTNAATLAGLPGFHRDDVDLPGDIALARAISPLVDISQHADAVQSTVAF
ISTNGVFVISPEQHGMSVPALLRRFSSMNYYRGQLPDRNPSRDVLWTPVYTGLQKGEAIS
TLSAPIYLNDRFRGAVVMDITQSRLLSLQLATADPGDVLENAPPVEFGLLNNNGNVVYFR
NGVLTEERPRRFSLALLQIARDSTGRWMQRGSGYIERRGDYLLYQRIGQTHWMLMAATDD
RELTLAAARRVFSSPLIAAWAVLVLLLVGTLFIVKNIFGNYVEASGRLETLARSDPLTGL
ANRRRFQEAFAETVERAQRADDTRDTQDANMPNAGAASDRSALAVLMLDIDYFKRVNDRY
GHAAGDAVLTLLAQILRANLRGVDVPARLGGEEFAALLPGADLATASAVAERVRLAVEVH
AQHLAGPASAAHPEAIPFTVSIGVAVCPADGPAHYEPLLQVADRRLYVAKESGRNRVVIA
DPQTLGA
>A0A4R8S4N8|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MPLNKVVAYIRSTAWMIFLLQWWTEPVPTGWLRSFLRDRKLDRTVRNLIGGYALIFAAIC
VALQFSDTGPRSTVGRVIVGVCAVGALGWAVRWAVGPWPSLREAVAFVVFADVGIAIACW
QDSDPLAGLVGAVLFTPVGAYVSFFLGNRLLVAHVAWCGPMILALSSRLFAEGTVGAAMT
AVVKVTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYGEWQRLHGGLMR
VHGVQGDRVVAAAIVDIDRFKSINDRYGHGTGDRVLVDLAEAFTGESIRGNTVGRSGGEE
FLVVTICPAHAVVDFATRLREAVTATRPAGIMVTASVGVAAQPVASVAAAASREAIDVLT
ACADRAMYEAKRNGGNQSRILHPEYDSGDHYLWQPGV
>A0A4R8SJH7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MSILPLGTIVNMHPLGPQGAGRTIHQSLIAVSFLVGVCWMVRPWPSRSWAISFVMWADLS
FAVSAWMYAGPMMRLAPILYMSTVGVFAAFLLGWRVLTVHCVFASAVLGSITLWNIHTGA
ATFLDQFLYNAPAFTTVVLLPILIQAVIEGGRRSIRAAVTAANRDPLTGLLNRRGVQSVF
EFELRKRPGPATVVVMVTDVDRFKELNDTYGHEAGDRALQAIADALFANIRDGDIAARIG
GDEFMVVAFVDNPDDIAAINARIRNAPIRSDTPETSMSIGIAWSSTDAEDFSFESLTREA
DFRLYEAKRDRAPRGSTA
>A0A511TMY3|diguanylate cyclase|EC 2.7.7.65|Neoasaia chiangmaiensis|TrEMBL
MTDQNVLAGHPPENAFPADRDEWQAILDTVAPAVRAEVATTVTRHAERCADIFYKTLLRH
PDAATFLSHDVINVQLHHALTNWLRTLFPESAPDLDTLIRIQRHIGLVHARTRVPIHVIL
HGARLLKYELRHHLFARQLPPQTLSAAIDYTETMMDLAIEVMSQEYVLDLTKEIEDDEAY
RLITLSQDVALERETQRGALLEWGQKAVLGIFGAATGPIQSLENAPFGLWLNHKGSLLFP
ANAGLRQIQSNVRHIDRTLLPGITAETPPSLDKVKDLQAALDEIRFLLDELFRKHEALEN
GRDPLTRVLSRRFLPSILGREVTSAFHRNTPFSLLLLDIDHFKTINDRFGHTSGDTVLRH
IAELVVTCSRGNDFVFRYGGEEFLIALVETSGHDAELTAERLRARIEESPILGLGDAPVR
VTASIGVATFDGHPDYTHLIEDADRALYRAKSLGRNRWATA
>D6CLU5|diguanylate cyclase|EC 2.7.7.65|Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)|TrEMBL
MGQETQARVADSWCEDIAQWAEHLPLMAACFDAHSHLLYCNTAYANWLGKTPAELLGKSL
DALVPHETLVTITQPIVAVLRGEIAQYERQGHHAGRQAKRWLRVRLVPFPPDEQGAVLGY
FCFMQDTTRLHASDTSLDLLRTSPGLTVWELDLQTGQLHAEQNWLDEAHRHEPKTFTIPE
WMGHVAPADLPALEQAIARISAPDGFVQTVETRFIRVDGSTVTTMNHGMVRERGPDGVAT
RIFGLTWDITELRQTQTRLQRSESRFRMLAELSSEWFWESDPNDVLTYITRSSRRASESP
LATLNLVGHNLNSLYPGQEFSPEWAQLRFLMEEHEEVRDLIVPFRLGPDQALLWWRIDAS
PMIDHLGLFQGYRGVVRDVTKAHQAEEKLELAAYRDTLTGLANRTLFEKHVEDAIAVTPP
GQSFAVLFIDLDRFKLINDALGHAVGDKVLVETAQRLVQLARPNNTAARFGGDEFLILAR
DAHDAAQALRMAMLVQQSLGEPMHHAERTLQTTASIGVAVFPQHGRTTAELLGRADAAMH
ESKMLGRNRVESFSVALQSRIERRSQLEEELRAAIANRRFEVHFQPIWSRKQNVLLHDDS
ATLEILRSAYEIAGVEALARWTRGNGERVQPDEFITILADCGLLDSFGPVMMSVALEGFA
RLRKEQGFTGTMAYNVSPRQLHVNACVSCIFDMAASFDVPRDKLVLELTENVEIEHNPDL
LAVFEQFRQMGVQLSLDDFGVGYSNLGYLTRLPVSQIKIDRAIASGVSTDRFKAAIARAT
LTMAKTLNLEVVAEGVETVADLLWMERAGCPMIQGWVFSRALNLQQTLNLLRDLRTQQTH
>A0A7G2JHG3|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MNARSYQELLNSKHRLSLFLFLLMNTASSLFTLLVPFKDKPAFTLPLLGIPLFCLVALLF
TLQSPRLYVRKLNLFSFVIGLLWAAHIYLKSQYCAPNNQSFLLISLFSMFFISAIALTDN
FIAFCLHAVPSALVILFLDGMHNTMRIVFTTVLPIIAFSIHHLMLKRSELFTQALVANLY
NERDRFSNLSMIDPLTGLYNRRGLENKINMLTAPPSGCHFVVLLDIDHFKAYNDNYGHTM
GDQALVQVAIAIRDSVRSRDIVVRYGGEEFLVLLTNVSEDYATQLAEQVRQRVQELKIPH
RFNQLEVTTVTLSAGISALDKLDVSSAIRAADAALYHAKNSGRNNIQLAQNTQPAAV
>A0A136WGC1|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MNNISKQMRCLAHLKGKLLADKVNLYQEEINDRNYHSFLGLSVVGVVISGSILIIGIPFP
HFFIYNKQIFGLFCLCIVLYFMGKLFLQKEKKYSTLAFYCALTPIMFMGILMGTFLDPRV
PSVTIMVFLCVLTLFMIDKPWRIIMFITCSAIVYVILCYKAKEYELFLTDVIHLFAFYSM
AVGINFLTVNERIDNVEGFVNYRIRSELDLMTGVYNREVGLNKIKQLINDGVQGAFIIVD
IDNFKRINDNFGHLYGDIVIKGVSRLIKKSFHEEDVVLRMGGDEFIVYSVNLVEVKECKK
KLECLLDCFSSSEAGEEKKGIPVSISIGCSINDKVQIDFNRLYRESDQCLYVAKQSGKGC
CVIKE
>A0A702GFK0|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDDAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGYFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A395LB68|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MTSLDEGLDRRAIIWITNWTFSGTAGCTAVAVLITYYYIAPFGAEVMVTSMRLALFIPLL
LAIPLFAFIGIKLQQLARANDLLTLASRYDGLTGCLNRAAFTSDVTAFVAEQDLKPFPTT
SALMVLDADHFKRINDRHGHLAGDDALVAIATGMRLAVGDGGLIGRLGGEEFGVFVHHAH
PATIGAMAERIRRAVAEHGQAIAPDADPVTVSIGVALFTYPVQYEDIFKIADDQLYLAKN
TGRNRVCLIEYSRLPGGIRAMATQLREGLAGAPTDGFARHGDAPSRVVGC
>A0A564M7Z1|diguanylate cyclase|EC 2.7.7.65|Klebsiella spallanzanii|TrEMBL
MDKPMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEDAYIANQRNNLENVSHE
LDSLLQFNIDRMIFFRNGMQSAMGTPLDFTVLRKAEQDYLERRHEPLWTVEIHNRRTLPV
YGVADAFVDSDELLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMMYVSRSGFFTTT
ELPKNSTQALALYSRATSDSWFTRQTQRNNPARGIVWQTFPEDESLRETQVVTASIPLDF
QRYWLGVLAMDFSVSEMKAFLVNAVKGGQEGEYQLYDTRLNLIASSAPGNVLTLLSPQEQ
ALLSRAFAHENQGGIRLLTRYISWEKQRNFDGVLLRIHTLREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDGLTRLLNRGALFDRAIAVTHLSERQK
SSVAVIQLDLDYFKRINDQHGHQAGDRVLSLVASTITSHIREGDLAGRVGGEEFCLVLPN
TSLKEAAAIAERIRIRLYAREILLRNCVSLRISASFGVSSSGDSSDYSFENLQSIADHRL
YLAKQNGRNQVCAEG
>A0A702DMI5|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNSMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7T1F3T4|diguanylate cyclase|EC 2.7.7.65|Atribacter laminatus|TrEMBL
MRAEQKYLLSIEQYPEGIALFREELSTDGKLEDFVFIEVNQPWERLTGLSQKQVIGKKAS
DILAEIDFPVENWISLCEKIWLNKTHLRFEHFFQPIDRWFEITSFYDQTNILVCIFREIT
DLDKDHDLMSPSIIEKDVKNLKLTDLIDKPALQSLINDFYNLTKIRISLLDVEGKVLVST
GDEEICRRFHHRHPGTKMHCQESNTQLTKDIPEGTFKAYKCKNNIWDIATPIVIEGKTLG
NLFLGQFFYDDEPIDYEFFRAQARQYGFDEHKYIACLNQVPRYNRDIVQSALTFVSNLAK
MISVMGFSSIKLTRSLEERNRYLREMRESRERLTATLHSIGDGVISTDKNGFITNLNPMA
EIITGWKATEAKGRMIDEIFSIRDEKSDFSYNYQIVGVLNGKGIHNFTNSIILIDRNGIA
KPIDGSIAPIQDQFGKRIGAVITFRDQSMNRAITRDLRIMKSAIESSINAIAMANLNGLI
TYVNSAALRLWGYEKKEEVMGKPVRYFWGKEFEKLQVMNKVREKGEFFGELSGRKKDGTF
FDVQISATLVTNEEDQPVCFMDSFVDITEQKWTEKTLAEEAIRRRILIEQSRDGIVVMDQ
EGGVFEANQRFADMLGYTMDEIYRLHVWEWDAQFTREQLLSQTQLVSEAGDHFETKHRHK
NGSIINVEISSNAAVFDGKKLIFCVCHDITNRKKMEEELRRERTLLRTLIDNLPDAVYVK
DRETRKLLANPADLENMGLKREEDVLGKTDFEVFPQEVAQLFYKDDMYVLNKGKPIINRE
ERLVRPSGEEHFLLSSKIPLFDEKGEVIGLIGIGHDITEQRKANERVNYLSFHDSLTGLY
NRVYLEEEIKRLDTDRQVPIGIIMVDINRLKLINDAYGHPMGDQLLKTSSGVLKNVCRKE
DIIARWGGDEFVIFLPKTSVKEIDSIKKRIIEQCKKTQVCSIPLSMSIGFSVKTQVDQDI
MKTFKEAEDNMYQNKLIESRSSRNTFLLTLKSALQKKNDISNEHIDYLQNLAQIFGEAVN
LTGTDLDRLILLVTFHDIGNIASPDEIVNKTGPLTKEEQSIIQRHSEIGYRIARTIDELS
GIAYAILSQHENWDGSGYPQGLKGEEIPLLSRMNAIITTYDEMTRKNRFNQGRICSKAKA
LKELERCAGKKFDPELVNLFIDRMKILSV
>A0A4Y7RFT4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum schinkii|TrEMBL
MLCLLLLKFISDTLGHDAGDGFLVAASGVIGRSFRKGDIVSRIGGDEFAILLTHSDEKTV
EDACNRIQEVTTRRRCCWHTRCCLKPPLYGIDLRLRLAIALRYGKGGNYDLIIVLA
>I6E0G9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINM
DMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGV
PLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSN
IGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVF
IDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESAR
FIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRG
RVTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWS
CEGEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSAT
LVNDLLEQLGNSPLPPRLLHLIIPAEAILDHAESVQKLRLVGCRIVLSQVGRDLQIFNSL
KANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIG
VDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A7H8UEB2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKDVTSIPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLAALGKQGQFSVAEVLNAHQKRFAWWAWNPANNTDTLGTLVS
RWLFPVPIAQPIMHNGIKIGEIRLTARDSLIGHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVTEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHSEREVQSICAALSRQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>I6E6D0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRGIEVS
SKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCVMLVD
INQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQAKII
ADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKSEGGN
KVIIHHI
>A0A8H8X9F4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MKNITLAEKLIMLSGAVLFALMIAVNSFCVNDNPGFRVPMTTYLIVMIALFFLDTIIFIF
IQMLYASDRTRFSLFILSLAFLSGLVYFIETIIVIQLPEHAGFTQAAKTNDTAVFHFFRQ
LSFIVLLALAVRVEKITIRSTLRFRNKISMTLALMMSLVMFPMLAHYLSSYHPAWTLTIA
AYEDEHHHPVWDIRYVNVLILLWSALLCYMISVTRLASGIWNSIIVVCLSAIVYNFFLLL
LDTYNLSLWYISRAVEVLSKLFVICTLMFHVFNLLKIFGDRVDRDPLTQIYNRKYFYEAL
PRIRSLRTEKGASIMMLDIDNFKSINDNWGHLVGDRVILAVVDIIKDSIRDNDIFARLGG
EEFGLLLPDTDSRQAIAVAERIRQNVQQRTGPGYHYALPVKVTLSIGVCSAIQNNVNSND
IMRDVDEALYEAKHNGKNRIVTRQAECS
>A0A8H8X2N0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWASINITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSTMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGVEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLIHGEINTYTLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPSHIKPTWQLWHAAMV
PEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDTDMVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A377M4H9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQMQTSCAWESTYVMSDIILARVSETLTTEQSLESLVRQLLEMLELVTEMESTYLTKVDI
NARLQHILYARNSKQMQIPEGLSVPWGDTLCKRALDSDTIFSNEVPERWADCDAAKALGI
TTYMSVPVHLADGSLYGTLCATSTEKKLLSERGEHVLKLFAGLIAQYIQKESLLSQLREA
NAALIAYSFTDVLTGLPNRRAIFEDLNTLFSLGRHLKRNVIIAFIDLDDFKRINDQYGA
>A0A240EIK8|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MQKLTKKYALLLLKSALVSSVIYGFAVFQSLDKLVKNEVAQFHLVTKSIQDYKSTVYILG
FLFEAQIAANKSTQVGYPLFDKGRVYLLNPGELLAHNERVVIMTAQKMFYSMPELALAKE
YLLYYRSYEGMKILASHAFGGVNLDVTEVFSQKVCVESFKCSKYASQEDLDNRIVVSDIY
RDNVTNKAVITISSPVYDGSRMVGDLNADVYLDKFPFLSNKQYVSRRTEAGREIIIEDRR
YPFAHSAHSQRTDVDTGLTIVYKIPYSKIVVDSLWVYLAMVVVFLYVLIRLDELKVKKEK
LKVAELAVKLDELTGLYNRAILRDSGVKYAVEKKGLAVIAIDGDRLKSINDNYGHHAGDE
AIVYIAQCMRKCFRESDYLIRSGGDEFLALLPGCGLQTAERLAVKLSHIVRSKTFGLKES
RLGISYGVAVVLDNESLSSAIKRADAALYQVKRNKSQPVNRVV
>A0A377M2C6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MYLMRILGTFLCFIPILSVLIEQNRSIWLMCLLALNAFIWPTLAWYRARNSAMPLVTEHQ
NLVLDAGAGGFWIAMMAVNPLPSVVIATIMLTDRLSAGGVTLMRKAAITMVGRFSGDLAD
AGNGGGYVRFAAHHVCHAAADCNLSAGAEHINGQHCAAPADQEPGA
>A0A8E4IQ78|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLSNEQ
VERQLKSAMEKWIINVLSGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFSDSSAAKEDENYRIFSLLENAEE
EKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGMDVL
TKLLNRRFLPTIFKREIAHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIRSRVEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQMADEALYIAKRQGRNRVELWKASL
>A0A8I1Z255|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MNQDTPDLARPTAGRRGRILVVDDQPANIVVAHQILRERHDVFMATGGEQALEFCRTTPP
DMLLLDVEMPGLNGMDVCRRLKQDPATQDIPVIFVTGLQNPQQELACWEAGAADFVSKPV
TPITLLNRVNAHLTLKFQADQLRVLAYHDGLTGIANRRNFDERLERAWRHCQRNRSTLAL
ILSDVDLFKKYNDNCGHHAGDECLRQVATAIQSQMRRPYDLAARYGGEEFVCLLPETTLA
GAVTVAIKIDAAVRALQIEHPASNVDACVTLSQGVAVIEPETGADSERLLRLADDQLYLA
KRTGRGRVCAV
>A0A447TA63|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPALFAIGLFGACAAAAWAGWEARRRGRYLRWFEQYPDAVLVVGKTGRILCANQRAAELA
GGDASRLANSPLSQWLPAGDPLATPAWKALFAAEGSQACGSLGLHVWRGVDGEACEWLIT
ARALSEDRAVLLSLRRPQELYPDQPKYYLAEKLLHTAESDAGIGSWVLHMESGRLEWSQA
VHDIFGTDSATFDATEDAYFQRVHPDDRARVRRELDRHVLGDRPFDVEYRIVRPDGQLRE
LLERNHIQRQASGQVDHLWGTVIDMTEHKQLKRQLQLSQLAVEHCSEGIAIADEGLDWLY
VNPALARMGGLTMADPSQLSGLFMAPGVEARLEREALRELLDASGAWQGELLLARRGAAP
LPVLASATRLRDEDCRLLSVWVVSDISGMKESERRLHALAFFDGLTGLANRALFGERLRW
HLQNEPAGGRLAILFLDLNGFKQVNDLLGHEAGDQVLREVARRLQAGCRPGELAARWGGD
EFAVLLPGVADDAVLAARLRELREAARAERWGGGRWLRVSASLGAAVYPESAEDAERLIQ
LADRAMYRAKSEGGGQVWLHDGGGLRTLAGADCGA
>A0A3S4IC52|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSLTAWLIRGGAPMVLTGERIEALCRQEALARPANLPAFWMGAPLRNAADELIGAAVLQR
YDDQPPLTSAEQLLFMFAARHVGFALDRVLYHRRLERQVALRTSELEGANARLRAEVASR
KRAEKFQDVLFRIAELSNTSLSLEAFLSGLHRLLLEMVAARNCVVALYDMGSDLISFPYC
ADEYAPALKPRKPGKGLIEQVLHSGRPLLLDPYGSLQGMAAAEGATPPKSWLGVPLYCDH
ELLGVLAVQSYDGDVVYGYRDQEVLEFVANHIGTALARVRALESLQHAYADLEQRVRERT
SELDAVNAQLEFDSLHDPLTKLPNRNYFSKALRRAWDAYLDGGDRFAVVFIDLDRFKLVN
DTLGHLAGDHLLFEAGPASVPACVITISWPGWAAMSSRC
>A0A7W3EE03|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSKPSQHVLVTLPHPLLHLVSLGLVSFIFTLFSLELSQFGNQLAPLWFPTSIMMVAFYRH
AGRMWPGIALTCSLGNIAASVLLFSTCSLNMIWTGINIVEAATGALLLRKLLPWYNPLKN
LNDWLRLAFGSAIVPPLLGGVLILLITPGDDPLRSFFIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYNQDELRALTFQQLTWPEDLNKDL
QQVEKLINGEINTYSMEKRYYNRTGDIVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EHINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWMQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQQADAHIERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIFDEQTFRRSFGDPALNHALDRRVLHEFFQQTAKAIASKGLSIALPLSVAGLSSAALV
NELLEQLENSPLPPRLLHLIIPAEAVFDHAESVQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNNSYFAIN
>A0A6N2XXJ7|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MEYQDRLFNQKNRASMDKIINNLPGGIIVFEMQENKIKTLFSNDGTYQLFGYSKEAFKTV
FHSDVFEIVYQPDLAPLQEEFYEATKNRESFEHGCRCFRNDGTLMWTYFRVNYIGTEDGR
NVFVGLITDSSKERLLEEKSRINEEMYHIAFNQSNVFLLEYDHRSKQVSCSSESSAAYFD
SAAFSNIPESLIDSDLIHERSFDDFYHFYHQIIGGVKTGEVKLKMRALNSDKYIWIHVKF
TNIFDDDNQPIKAVGVYQNIDEQVRLESRYLQEIKYRQKLMQRSITNLEVNLTTDEVIKA
HNVTYNLLGLDEKASYSEFIKKMVTLVADEDKHLFLDTFGLDNVRQAYHDGKDDLRISFL
FYRPTKKRYGWVSTHMMFLYNEETNQLMGFFYANDIDDDKRKTIELTRQARTDALTGLIN
RRELERVITSEIQLVEPGNYGALFMIDVDNFKLVNDANGHSAGDETLRFVANRLKSLFRG
DDVVGRFGGDEFMVYMKEVGAKKDVISKAKQVSEALATTCPGSKIDISCSVGVTFVETPR
VIFDEIYHQADSAAYEAKKNGKKSYHIFE
>A0A1Y0HKV1|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MYSVIVIVELILLVIGALFLIRALTPISHLILELPEGSIKERWKVLSIFILFFIAGYFIF
GYNLWLLGDEFNHLSIITSITMLFGGVFAYLVGQLALHTMNDVKNMAILQHESITDGLTN
LHNRRYFDERITEEVALSKRYKLPLTFMLLDVDHFKKINDTYGHKVGDEVLRNLSKVVLE
VVRDSDVVARYGGEEIAIITPSTNKQEAELLAERLRGIVEKTTVSTISTTQEVIQVTVSI
GICSLSAVITDKDALIEETDQALYLAKKYGRNRVVVSNW
>A0A5K1I4Y0|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MPIPTRQQTQRPQWLIGLVIMTVVGLGYFAGAWLGVTQTISPDGQAIIWPPNAVALAALL
LLPVHRWAWIIPAVMAAEIIADIPAFPLWAAVSFGLVNLFEVFLAASLVRWFTGPRFDFD
SLARGGYFLLFGPLLAAGTAALLGAGVYRGLAGEEAEYLAHWQMWWFGDALGLLLLTPLV
VIFARQWREMLHAWTRWRLLEASALLLLLGVMGMVLMATAGVEDGGHPLSLVLLLPLVLW
AAARFGVPGAAALVALVTATAIARTLYGAWPLHGEDPNGAILALQEFLAVTATVGIGVGL
LLHEIEAQRMRLHLFERTMESTNDAVIITDARRRDDPIIWVNDTFETLFGYSRDEVIGRN
CRLLQHGEEDQDGVRKARDALRLKQPVKTLVRNYRRDGQPLWIQLSLAPVGDSRGRVTHF
VGVLHDLTELKHLEEKLERRVAERTEALQEANRRLERIAATDPLTGVANRRQFMRQAKRE
LARAQRNGTTLSLICLDLDHFKAINDVHGHQVGDQVLTQVASTMEQNLRPSDLLARMGGE
EFQVLLPDSDIRQAGEVAERIRATLHELEIRLCDTVVKVTVSVGCAQMGLDGSDMDSLMR
IGDQRLYEAKSLGRDRVVTGTADGVHAI
>A0A4U9TYG5|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MWILLAVNGFIWPHIAYQWSIRSEAPYATEIRNLLIDALLGGMWVAIMGFNALPSVVILS
MMGMNNIASGGPSLYFKGLMAQIIGALVTSAILGFPFTPQSTPLQVYLCLPMIFIYPVFL
GYVTYQTAKRLAEKQQELLRISTRDGLTGVFNRRHWEHLLHNEFDSCRRL
>A0A1Y0N5W6|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MVSPERDTSTLFEHLPIGAYRVAVDGQILQVNAAFLRLHHCQDFAQLHRFLKERGFNTYV
QPQRRKDFESEMRQHGKVTDFVSEVFRLSDGKPIWVREHAHALTDKVGKLLGFEGTIEDI
TRERKARSALRKSEAMLRNVMQTIPDQIWVKDLDGVYLTCNDAFAAALGIQVEDIIGTRD
AHWVEESIAARFLLSDQWALQTGRTVTFEENNASQINPDEQLFEVHKTPMRDAQGKVIGV
LGVSRNIQARKDAEALLRDTTEQLELAIMGAELGRWDHDLSMEPGYRMDARAFSMLGRAS
DDATLPRAWSQFVHPDDLAHVAQALHSHLSGQSSAYQAEYRALHANGSWIWLSSRGKVVQ
TSKEGTPLRMVGTLMDITARKQAEESLLATRAELQATLDALPDLLFEFSAQGHYRAVHSQ
FKGALRMAPDKLIGRTIHDVLPRDAADACMVALRQAAEDGRSNGVQYCLDVGSNQKWFEL
SVVRKPRVGDEELRFIAIARDITERKEAEEAIRHLAFHDALTGLPNRRLLTDRLQNAIAQ
SQRSRENGALMFLDLDRFKQLNDSRGHEVGDQLLQEVARRLQHCIRQVDTVARLGGDEFV
VLLHNLGVDTEAARLHASMIGYKILASLNEPYVLGDSQHSTTPSIGITLFAESPTGPSEV
LKKADTAMYAAKQRGRNNVCFFEDIPPIAPAKSA
>A0A1Y0ND58|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MATLIEHLIKLTDHRDRDLLELTLSKALIDLVPIQRVLVSKVVSEEGIKRWMDVTVLDAR
GGGKVVDPLRVDFQTLPLLEDNRDRLHCIQGQERVEIAWAGEDGPRITYLPLFTDPVAGD
EGVLEIHSASPLQDDQLAVVGDVSRVFRNMYRLLAYSDRDALTGLLNRKSLDDTFYSAVL
EELGQVEETAAAARQPALSAGQERRHRVPPNYWLGTISVDSYGVINDQHGHLIAEEVLLL
VARIMNNTFRTYDRLYRFGGEQFAVLMHCPDEALVLAAFERFRANIEKFNFPQVGRLTIS
GGFTRVSPDDSPSTALERAERAVDYAQHHGQNKVFSHAELVRKGFFGEALKIGAVDIF
>A0A851GDK6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SECR19-1250|TrEMBL
MSVQNLSQDDAHRTGIRFARRVRLGRIVGLAAMFFPVAGVLVTHFLPGGWWLLLVSWVFI
WPHLAWQFTCRSSQPYQCEIFNLKIDAIFTGIWIGLMGVNALPSAALVMMMGMNMMGSGG
CRLFLSGIAITTLSAVVTLKLTGNVVVLSSGSLEWWLTLPVLMIYPILFAWVSHQTAIRL
AENKRKLELMSTRDGMTGVYNRRHWETLLRMEYEKCRRDHGQTTILLIDIDHFKSINDTW
GHDVGDEAIIAITRQLQMTLRAGDYIGRFGGDEFAIIMSGTPAESAIAAMSRVHERLKKL
SLPCAPNERLRISVGVAPWGTQFAHYREWLKAADIALYKAINAGRGRTEVAA
>A0A1Y5RZ67|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MRDLEDFAGIASDWFWETDADHRFTYFSARMQEVTKIRPEDVLGKRRDEQLAVCPDNASF
EAHLEDLYNHRPFRNLEYKIKRQLSDGYLWLRVSGNPVFDPEGRFKGYRGTGHDITLEKE
ALERLETANAALSAKNQELEVLRRELELAAFEDPLTGLPNRRAFDGEIDEALHGDRSGVG
LLLLDLDRFKWVNDTLGHPAGDMVLVKTAERLVNRCDTKAKAFRLGGDEFAIIVPRCPSL
EDAVDLGRAIIKDARQPMSFSSVDFEIGASVGCAVTHGLPSSPSRLFKQADVALYDAKNG
GRNRVMPVAKNVA
>A0A826L6M3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A506PE06|diguanylate cyclase|EC 2.7.7.65|Pantoea anthophila|TrEMBL
MTIEIFAPQNSTPGRWLSALLLGCAVFVLTLFCLELIVVSVKISPLWFPTTFMTIVVFRC
PLRQLPLLLTACVLGTAAANAIVIGPALSNIKFALLNLVQAGVGGMLLRALLDRRAPLNS
LHDWARLVLSVGIVTPLLGGLMALWMLRVSGHASFPFFYTWVISEIIGMLVLGPMLLLMP
WPLRRAHFSDLRPAECVLTLLITLGASYLALRFMPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFIALLLACNLVSVVNNNTALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPQGNWLQVNRSLCQILGYPAEELKRLTFQQITHPDDLAL
DLQHVNQLLEGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDGDTAPLYFIAQIIDISELK
KSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWLHL
LHTADREYAALTVQQAIELRSAFHMEYRIVDAQGQRWIRTQANRQLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDEAMRVAFMNPVAEKMSGWSQEQAAGK
PLSELLHITQGQTGPEVENLLLCQLPPEKITPDLDEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHHHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSELMQHHLRSSDFLARLGGDEFALLMADCQV
DQARDVVQRIVAAVNDYRFQWQERRYQVGASAGVTQISADNCVSGDVLSQADIACYNAKR
SGRGRLVVFEQHRLPLPGNPQGVDAAMIDALQIELPAWAVAPPKTPQSAFIWLLEVQLLT
AEGILVDETLLRHNLPDETLRRRLDSNIIEAFFRQDVGTLNKKGIPVILPLSEELLGDAA
FVQQLCQRFVAAGLASSRCGFAFPAASVLSKSDRFYTALLQLRECGCRIALHHFGRNLDA
FNLLSDEVVDYLVLAPELVANAHTSLMDEMLLTIIQGQATQRHISVLAGPVSVPAVLSTL
ADLDVDGVWGSAITERQPLRSLAEDRLFAIR
>Q0T612|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQ
KVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVSFCESP
>A0A7L6TZB7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C21|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A826L9A1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDNSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A645INF9|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MIGREVGVLVIDIDRFKTINERYGHEGGDLVLQMLVKFMSSSLRRCDKVFRYGGDEFAII
LANPDCAEVEAVAQRIAGVIASTPIVYSQGKVLCTVSIGKAKGYIVENGDLDSLIRVADN
ELMTIKNLRNPK
>A0A2W6KF92|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia|TrEMBL
MEPPQLDDASQPLAEAWQHCLQQAGPAATALLHAAVTDAPPALARRFYEVLLQDGRARRF
LSHDQVKQRLQPAMQRWLVQLLTTDADGIAATVASQRVIGDVHARVGIPVDLVTRGARVL
KHELFVRLRDDAPDSATAFAAIDCLSAIMDIAMEGMTLAYTHARERSTRADAAYRLFSLV
QNVGTERERQRALLLDWENALLYALAGHVQGSDSASLASSEFGLWFTHKGIPSFGESSET
QQVGQLMARIDDRLQQAATDTPAQRLAVLPAIREDLAAIRTLMTLLFERIGELDAGSDAL
TNLLNRRFLPTVLRREIELATRNRTPFSLLLLDLDHFKAINDGHGHDAGDRALQHVAGLL
GQLTRGSDYLFRYGGEEFVVVLVAASESQASVIAESLRRQIAQSPVVLANGQVLELTASI
GVAGHDGHPDYERLMARADAAMYEAKRSGRNRVVVASADLQEAPGRRALQR
>A0A644Y211|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLFVDLDHFKQLNDRYGHAKGDEVLVRVAQAVRDCLREYDLLGRVGGEEFSIFLTGTTLD
GGRTVAERIRASIEAQRVPFHGGHIRVTASIGITGSCCSVRPLTSIHEIQPLADKAMYEA
KLAGRNQVAVFGA
>A0A1V5T789|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin269|TrEMBL
MAITRKDTSEFTDINDAFCLTFGYSRDEVIGKTSRALNLFVNDDNWLFTREKLIAGGRIQ
NRELVMRKKDGSLIHGLFSGDMINSQGEEHFLTVLIDVTEESELRAELTTEQKRLENVIE
GTRLGTWEWNIRTGETVFNERWAEMIGYTLEELSPVSIKTWSLLSHPDDLAESDRLLEEH
FSGTSEFYEFEGRMKHKDGRWIWVYDRGKVIERDSEGCPVKMYGTHADITEQKKMQEKIT
ELAINDTHGHIAGDIVLKEFANLVASMVRTYDLAGRFGGEEFIIVSPESESAQIARMTER
ILGKVRDTVFATETDKIRFTFSAGIACSTEVPGNPPIIAELLALADKRLYQAKAEGRDRC
KWN
>A0A564VCW3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pseudocatenulatum|TrEMBL
MTVRAMFHICMELWGIFICLICAGGIFIATPQKTRRTRIKILMQIACMLLLGADALSWYF
HVDAGETTYYMVRISNFSVFCINYIFMSFFATYVWLTVSKHQHRKPAALYAVYALSVIGI
LLLIITQFTGLFYYFDDHNLYHRGNFYLLSQAIAVLGIALCLFMLISYRKNLDRIIFLSM
MSFFVLPVLATIYQALAYGFSLQCLAIVISTQIMFVMDTVEMNMRFHSQQAAYEKARYEA
EHDGMTGLLNKEAGWKHMRKYFDRMDLHDEAMLMFVDIDDFKIINDTYGHTVGDFWIREV
ASQLRHIYRQDDIICRYGGDEFIVLIRNTASEQVLETTLGMFFQQLTRTSEQRGQDVHCS
VGVCRIAAIRISGNRDISRNTDEGNGEDTRGGVDFDQCVKQADLALYETKRFNKGTFTVY
NYDRPSQHPQSAPRNGRKV
>A0A0F6TUW4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus Y19|TrEMBL
MENWGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKQLQFNVDKLLFLRDGMHEALIAPLGFSALKDAVTHFEQLRHSRVWQLELDKRRTLPL
NGVSDSFVNQTQVLSRDSESLDNELTAALEVGYLLRLAITRTSLSQQAMYVSRAGFYVST
LSTSLSSEITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTSPLPGLNYDQQRVTVSVPLDN
DHYWLGVLAMTIPVSAVERFMDEAIDKDVEGEYQLYDSKLQLLAASTPELRNAKMFDERE
LAMLAHDIEQDTVGGLRMGSRYISWERLDHFDGVLVRVHTLSEGVHGDFGSISIALALLW
ALFTAMLIISWVVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKQLTQRCRVQ
KQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRSYDVAGRVGGEEFCVVLP
ETSLAQAEQIAERIRQRLNEKEILVAKSATLRISASLGVSSTQETGDYDFEQLQSLADRR
LYQAKQAGRNRVCAADQN
>A0A5V9L7N0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A378YLR2|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MKSTISRTEQGNRIAATTILVACAALTLAGFLTRALEGTVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIASHVTRAPFWLWLMAEA
SFAAYVMLSVRSYTRTRGDPHTRPGYTEAARYGATVLVIWIVVSLSLVGAGRTLVTPHLA
AGIDVETLALGALFATYVALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPSEAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRLVADRVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDTVLQRIATTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKARDEGEAITISVGIASWQP
GEPLVISAMLEQADKALYQAKHKGRDQSVLGQQMAA
>A0A2Y6DWS5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPIMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFAHPLPIEIFEESYLEEK
>A0A719ZT87|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. 404ty|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A381H2A3|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MPHETTPGNWSWLRTLARRFGPGHVVNICFLVVMICSTLLTWREVVVLESAYRASQRNHL
ENVANVLDRQLQFSVDKLLFLRNGMYEALVTPLDFADLHDAVAQFAQLRGKSFWQLELDR
RRTLPLNGVSDAFVNRTTLLTRDNDALANELSAALELGYLLRLAHSSTMLAQRTMYVSRS
GFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQRQNSARGVRWFSSPVPGGEVQQKVTVS
LSLDNERHWYGVLAMDIPVSSMKRFLEDAVEKDSEGEYQLYDYQLRLLATSTPEKRQVNT
FDDLELALLANDIEHDTHGGIRMGSRYISWERLDHFDGVLLRVHTLREGVQGAFGSISIA
LGLLWALFTMMLLISWVVIRKMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFERARVLIQ
RCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDRVLSHAAGLISGTIRSHDLAGRVGGEEF
CIVLPGTTLVQAAQIAERIRQRVNDKEILIAKGTTLRISASLGVSGAQENGDYDFEQLQS
LADRRLYLAKQAGRNQVCVRDDHPAPSPDTR
>A0A5J1BZP9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Coeln|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A162EAS0|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MTWSHWEITPFITSVFFILGVLTLFWVSQNWIINFFNTHHWRVDQSLITDWYGLIYMMLF
VFGMQTAVVGQNDAWIFMNFQLIGLTFCGYFLNVRVRYYYLYPLVFIFMGFNHSLYYWES
WGHAVTLILFFTALGRLRKHVPLQTKQGQVALYLVTCAGFGAVLWWFMKLKFNLSWATYW
QEWTYLLVFASLLYIYASMLSANAHLKQNLVAFANHDALTKIENFAAYKTAINYQVTSSR
KNGSQLTMLMFDIDHFKQVNDTYGHLAGDKILQHVAQVATIVFHANNPQISLYRTGGEEF
NVIFPNYDLTEALAVAEQLFAAINHIAVPVNDHQIQLSISIGLSELAADDQSPTAFYQRV
DANLYHSKKHGRMQITAK
>A0A0F6UBQ8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MAPPKQSNTIDFDAAKQKRGAQPGAGGVPRAGNLMELRQQLTQQLQSSLEAERILGLFFE
EVRQLIPLDALGYRHPGSDLRLEFGSSAKHSVSYRLSHDSDYLGELIFRRRQRLGEEEQR
QLESLLGTLLFPLRNALLYRAAIQTALRDALTGTGNRIAMDQALGRELELARRNLQPLSV
LMLDIDHFKRVNDHYGHAVGDEALKAVAETIKDHLRNVDMVFRFGGEEFLVLLSSTPLQA
ACMVGERLRQAVEELDYRHAGETLKLSISLGCADLRPGEGSDDLLRRVDEALYEAKRDGR
NRLRCA
>A0A5J0RNZ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Napoli|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A736KDX5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MNKEFPLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKGNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9IEB4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3V3TXK0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Havana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYKTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A381IBT0|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLEKIKKFFGFPLDKKHKDNVEKELCNYLYHTGKIICIIIVISQIIMMISISAREGGPF
VTPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCCTFYINLWIIYVTFFCLWGCVITL
LDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLFLNLFLPGIQTIPGNEFSNIV
NTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEISHINNLLNDKVMTDDLTKMNNRR
YLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNYGHQKGDYCLQNIAKVILDFTSSEN
EHAIRYGGEEFFICIFNCNEADAKLKSECLRKIIESCNFERDDVPLKCVTVSIGVYTKKI
EKTITLNEFISNCDKALYTAKEQGRNCVAFY
>A0A4Z8YQX7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4P9T552|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3Q9LVE0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 43:a:1,7|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0T7RZ19|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0M6WSM1|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MKKPDLTKYKTTSTLYLLILIIAAVALVFGWQCTSYSLSNHSADLHIQMLPSRRVKVSKA
TTVYRISDVRWTKKASTLMFYSQHQTVVVEVDGKLLYTRSLKTDSILHTTGRNCEMVSVP
ENTRSILVTLTNCNLDKQVSDPVFYQGDGVHMFRHELLKAGIPMLLGIMNVVLGILMLIY
WLFVHHWAYVSKSMLYLGILTTDLGAWFCLETSSSILLSQNPVFHSYVTRMLLLLLPIPF
MMFVRHYLKARDRYLCRIFVWLDVAEIAVVLFLQLMDIRDLTQTLWMTHVMIGLAVLYFI
YTICNKFYHHTTTHALWICTIGIIILIGTLFSDMYNYYQGSQDIEIVGRIAMLLFIVTLA
CDTAFVSLKEIDTGRRAALYRELAEKDLLTGCYNRNAYHEDTSRCKKLTNLLLFVFDLNN
LKYYNDKFGHDCGDQYITDAVHILQKVFSRYGKLYRIGGDEFCVLIDDHNTCDISHLISC
LRKEEAVYNASSRNIHLQIACGYAVFDSRTDADLDALQKRADQNMYENKKQLKTFSYR
>A0A100J2Q6|diguanylate cyclase|EC 2.7.7.65|Streptomyces acidiscabies|TrEMBL
MNARLALLGTVGPGIPESEVFRLALQHAVAELGALGGTIHLRGLKSPLRLVSSTGLPTAL
TRTWEIIDHNGPLAPARALHRGSGVWDPLPGDATDPAWPGTGLAALPLYRGEHSIGALTL
LTGDSGQPTAAQWSYLRSLVSWAEERMGQAPALTHRPRGEQHARLRQALKEARVGAWDWD
LTTGALSWDEAAMELYGTRPADFTGHIDSWIRVVHPDDLAPTLTLAERAVRDHAVFEAEY
RVRALDGGWSWTRTRGKATYHADGEPHRLIGMAWDSDDSRPGRDALGRALRHMSDGFLAV
DDDWRITFANLEAERTLGLTEEELFGRTLWDVPAVRYVPGLEQRCRKAAAEERPTEFDIH
PSDTCRRFHLRLVPGPDGRTLYFTDVTEKRRLADERRAGERAASQRAARIAELTAALAKA
TTSADVVEAVARRVLPPFAASGLLVQVIEDDRLHNVGAVGYPDTFLAEVEGRRRAPRDPS
WDAVTHGTPLFLSTARELVERSPQLAGMPERAGKAAWAFLPLTASGKTFGICVVAFDRPR
RLTDEERTLLATISALVAQALERARLYDAEHTRSRELQRSLLPDALPALPACTAAARYLP
AGQGMDVGGDWYDIIPLSGGQVALVVGDVMGHGLSEAVTMGRLRTAVHTLADLELPPDEI
MGHLNDIVGAMGERSYVTCLYALYDSTTQTCSIVRAGHPPPALVHPDGTVHFPDEVVDPP
LGAARPPFETVELAVPEGSLLVLYTDGLVESATREVDQGMADLGQLLRTAHRDGTAADLE
ALCDRLTAELLPADQQAADDAAFLVARLHALPAEKIASWSLPDDPRAAGQARGHVRDQLT
AWHLDDLIPTTELLVSELVGNVVRHARGPARLRLLHGTDLVCEVFDGSLTMPRIRRATDT
DEGGRGLQLVSALAHRWGTRYTATGKCIWTEQPVDGSGVLPGFADAEILPEFADFDGDLD
KLPFGDDW
>A0A1L8Y595|diguanylate cyclase|EC 2.7.7.65|Staphylococcus hominis|TrEMBL
MIEAIIYNIAVMVAGIYLFHRLQYSENKIMIFSKGYVTILMTLVALLLTAYPIPFHHQYL
IRLTFVPLLFLGRYTNVGYTFIASLIISLVDIFLFGNSFFYGVVLIIIGIIVSLIGPFLK
KNDIIALIILNAISIVIIFVLSIFTTLYDLTELIMLIPISFVLTITSAITFVDIWHFFSL
VTRYENEDKYDYLTGLGNVKEFDRHLNKISQKAEIEHTSLALLLVDIDGFKDVNDTYTHK
AGDAVLKQMSQLLKNYVPHQFKIFRNGGEEFSIVIFDYSLDQSVKLAENIRMAVEKSSFH
LPNKEVIKLSVSIGVGYLSQDEYKSQRKVFKDADDMVHVAKKEGRNQVMFNPIIKL
>A0A3T2UQS7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A380U682|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MFRKSSNTSLQKIFSQSQLLIFALTLGICSLIFVVISIYTMNTYAKQSLNIFSATLSEQI
QPAVIFNDPITLQQTLNNHIQQYPIRAIQVINLQGKPLAEAYKPTPEFAWTENLFDKVFF
KHPMTRTIQHQNNQYGTLIIYGSATQLMSFFFQLLICLSAGIFVILLIMLWLVHSTYQKL
MHSIQPMVNTAESLNLDTQYQARLPSSPIYEFRVISGAFNNLLDKVQRTNEKLQSENSQL
SHQALHDQLTELPNRHYFYNILFNQFEHPEKNQTALFFIDNNNFKNINDVYGHLAGDAVL
KEMAQRLKKNVRSHDVVARLGGDEFAILLRNIKHYDHLELICEHLIECSKAPLSFDQHQI
YFSFSIGVAFSKCATTPEDLIAEADNAMYKAKNLAQGWYITPCLNPDQESSC
>A0A729PWS8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 48:d:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5A9DQ69|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGLRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A239RSF7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MIKKSVFHSLDLQKLILILIIGCVSSLFLISIFVLNYVIKEQLTENSLAANQRYASKIAF
STDKYFESMLSELRYSAQIVGQDFSNQQVLKAEVTRLKGQSQKFNSITIIDKNAFILEYS
PETLHVNQKKQYKTPGITEALKLKKTYISSPYKGLSNNLIVLIAQPIFNRKNEFLGIVTG
SIYLNKENLVSELLATTYSYKKSYTYVVDNKNKIIFHPDKARIGDSLKNNTGMQYITSHP
TGKIALVNSKGIENLAGFASIPSVNWVVVSQQPTLELLSQANSIIIKVTLAMLGFYLLLF
IFVWKLSYWISSPLNKLAQMASMLTRPNIDQDIKNIDPWYFEALRFRTALLLSSKHFKDE
IAELKQHVNTDPLTGLYNRRGMKLFLNELEATNTPFSVLTLDIDHFKAVNDNYGHDQGDN
VLKKLASHMKSNFRQHDVCCRVGGEEFIVFVVHEDPKIAYIAAERLRKTVAQSYIDPIGT
ITVSIGIASWPQDSENIQEVIKLADQKLYQAKNDGRNCIRSTSLD
>A0A1R0FZY9|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A0D6HMU7|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MLRSRFSIKSLERYFLILAAGVVLPMSVLTGILLIQSRTAYLASTDAMRAFGVVRATVAA
MEMVSAERGPMNAALGADYPVAQPMLDALRQARDRSDTSIAELLALYRAPLSPNSAREFT
NVQRIRHALLKAREQADIVIATRRADVSGLRVQAVVDGMVALVPELQAAMAASVGVVMQN
EADAPNLLTLALLASELREQAGLLGSAFTPALAKHRQLTEADEYRIERVLGRIDQLRDLL
ETRMATRPDLRASLAYNDMRHFYFDEGMRYLEEVRDMAALQPGGARLTTRELAAAYVPLM
HAIGQFRDLMLDQMEQSMRAHRAQAMRLLLITLVAATALAAALMLSLRQFRRRVIRPFVQ
ATRIIGAIADGTPAATIPVGKYRGEVNGMFEALSVLKDNAAARRQAELERDRLIVDLAVM
AETDFLTGLLNRRAFESRLEQALAQWRGTDAVLAFILFDIDDFKGINDTHGHASGDEALK
TVAGLCRQTWRQADVVARVGGEEFAVLCHVGAADHAVQAAERMRRRIAQARVTAQDGAVF
TLTASFGVAYASWRNAEAADALFRRADELLYRAKMDGKNRVVPGEVG
>A0A3S4F4K1|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MKFPGVPENEEERLKSLYLADLLDTRDDERFERLTRLAKKIFQVPVVLISLLDRERQWLL
ACQGLGIRQTRRDISFCAHAILQDGAFIVNDAVNDDRFYDNPLVTGEPYIRFYAGYPVHL
PDGAVAGTLCLIHTTPREFNDEEIAVLKDLAYIVEDEFQVIGMAMTDSLTGIANRRGFYR
IGDKRFRTLTSNATPFSLVFFDLDKFKPINDLWGHAEGDEVLKTFAAFLAQHLLPGEVVG
RLGGDEFAAIITRNGRADTFLQKLRESVDHYNQTSGKPYNINYSYGELQSDVSRYPTLGD
MLKQSDEVMYSRKRRKTL
>A0A484U0L6|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSAPTELLATTWRRAQARHEPGTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIAFNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLGDAPVAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENTFVYEIAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCAAIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQKASHLSVLSIDIDHFKGINDQYGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQAIAIGEKLRRRAELERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADTALYGAKRAGRNRVLANSAL
>A0A484RPV1|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSASTELLATTWRRAQARHEPRTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIALNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLADAPAAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENAFVYEVAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCATIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQTASHLSVLSIDIDHFKGINDQHGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQATAIGEKLRRRAEHERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADAALYGAKRAGRNRVLAHSAL
>A0A737VXM1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:d:z6|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A398TYM4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A3G3DWJ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2P1BA97|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
METLDSSTFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKSQEELCANLNLLFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A3Z4YAD8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A377PEX2|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNAKNYDDLLNSKSHMTFLLFILLNGATSFYALLNPLQTDPPYTFAGIGVFVFCLFSSIS
LIWHRDKYLLKLNVASLLLGLLWSFHIAAKYQHVDANSHEFLLINLFSIFFIAAVALSDN
LLAFCLNAVPVAITVIVLEDFHNMTRILFVLTLPIIALSLHHAMTRRREAFTRRLVTQLE
QDRARFSDLSMIDPLTTLLNRRGLEFQFHHMGSDCDTEHKHFVVMLDIDFFKLYNDHYGH
QYGDIALKSIAQIIKEAVRTRDLAIRYGGEEFLLILRDASESLAIQICEHIRLHVEQLAL
INEYQPNGSNVVTISAGLSEMHGNNLENAITRADQALYISKQKGRNRVLLQKET
>A0A3U4Y9P2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
SLTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2R7ZWD6|diguanylate cyclase|EC 2.7.7.65|Carnobacterium divergens|TrEMBL
MDAFLLVEPYITGIISILGIFFIEAFVVASFKLYINQFLSPKTYHIMITLISGLIMTFFS
IYFMMMSQKEDYYLIFGNLRMIIILIPIIFLNRNISLVSVILCSVFRLFYYGTTIVSLGY
ITIFSSFFLLVVVIQLIVKQNQVLTFIYSILSASVFWVWIYLTNFDGYHSYFFVAVVSDY
LNFVILSSIAYVSASYLYHLNNLLFQTIEESLTDELTKLRNLKDFNAKMDDGFLKAREKR
EAFSLIIFDIDYFKTINDTYGHLAGDLVLKNLAKTIKEIEELKKVDVFRVGGEEFTIILT
KKNGTESVRIAEKLREKVEETHFYYDNQLIHVTVSVGVTSLVKGLRSEITSNGFLELADE
ALYHSKHNGRNRVFISDVFTGEFK
>A0A3V2EPG6|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A486FLE7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHILTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A3V8XN87|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6C8RV52|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQVRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A1D7Q1E2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMSSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0J2DH65|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVPPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A2S8JWP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWMQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNVWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3M9R3Q7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQEIADHNMYQAKHQRAEKLVR
>A0A827QEG5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGM
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A6N4P2Y5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDIERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A192ES56|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLLEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNRSYFAIN
>A0A827XBD8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAHDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2H9A3P8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASSADTLERQAVEQRQKFDQLTEDIETDIWAQS
DLARLYVIKKDPQVLKEYNQAENSLKSIELRLEKLQDNGASDEELALLHEGIKIVDELQD
EQQTALTSATQGEDAQAVALLYGAPYEQELERAQSQLDHFRQILDKRVIASVQDATKKSK
ALRTASELMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAIRIFRENGLARQRLERERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYVLDREPWQMRCVAQWLSPVGEETSFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPAPQADSSLCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQTAQALRTGEPLSCMMIDIDHFKSINDRFGHEA
GDQVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLPGADEPEAHACVQTIYTGVHELSIRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A0L6Y429|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNTIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A400NQ99|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFRSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5F1DQV8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLSGWWWLVLVGWAFVWPHLAWQLASRAVDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLKSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
RAGRNRTEVAA
>A0A377ZZC1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A7A0HA94|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPVMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISSLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>C3T9M8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LRPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEETLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X1PMU4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPVSQKLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLD
ESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYR
YGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDV
VIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A738AWG1|diguanylate cyclase|EC 2.7.7.65|Salmonella abortus-equi|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Z6V7B5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium var. 5-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5J2DE62|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mikawasima|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C6FTH9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKSNKKILYLVIFTFFVIICLLGHRVIDLSKLESMERDTINKAKLQIQKGNYDLAEKKLE
YILNDKHKFKTLSKDDKFDVLNYLGVINTLQGETVSALLMYEKADKYVSKINKYKVEMNT
AIAYRQIGEYLKSAEILVKILTSKGKIDGDNARVKTYSLLNLAEIYLQIGNTEEYSSILE
KVEDYIYDSPKEHRDDLLIIYYSDLIIRDIYRNNLDKVDYYFNEINKLKNKNDEVYYTEN
NMFKTRAYAMYYEKIGEVEKAIKYFDKLEEYAQKEGDTFIAQFSIRERIEIYKRLGDKEK
YNELLQEFYNKDQEILDINDKQYDFHLNNKILEQSNIGAMKKTVVLFILIDLILIAVVIF
IYEKMRKSKTDSMRDALCNTYNRRYLESYKIKARKGDFPLTVLMIDVDYFKLYNDNYGHQ
KGDEVLKCISRVLKSSCRRNDIVFRYGGEEFCVVLKNTIKEEAIALAQRIKENVANEKIK
HEYSKVDDYITLSMGITTVYSKENLRKSIALADKALYMSKESGRNKYTYI
>A0A078MHJ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas saudimassiliensis|TrEMBL
MARLSLDELAAHWQHQLNRFDDAVKEGTAEVAMRHKQELADHFYAALLGHGEAGALLSHE
DVKTRLNNSLQGWLVNLYSSQQATEIQALIAHQHKIGEVHARIDVPVHLVLHGARLLKGR
LVELLHQQLGPAQRSQAASYATTLIDLAMEIMSQAYAVSHERRSRAEEGYRLFAVTQNMA
NEKERQRAALLNWESQLMFDHAMGLAADQLPRLRASEFGLWFRHKGAHGFEGALETGLIM
DAITEIDDVLLPLFAQPATGEAPHSPTQLLREVREQSRSIGHHLELLFEQNNELESGRDT
LTRLLSRKFLSVVLSRQINYARQAGNSFAVLSIDLDHFKQVNDTYGHEAGDLVLQQFASV
LLNQSRAGDYLFRMGGEEFLVIMVDVNDANARRAAEKFRQLTASETFRLPQDVTINLTAS
LGLAMFTGHPDYQQLLRRADSALYEAKHSGRNRVVVAAN
>Q9L401|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A344SLU7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A701P2I9|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A0D7E8M4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSNSAELNELHWLLAIVQSIDVGVVVLDRDYRVEVWNTFMENRSGLQPENARNRSFFTLF
PEVDEDWFRRKVESVMTLGTPSFTIWEQRPYLLRFKNYQPITGLEDFMYQNTTLLPLKGV
NGSIDQVCLIIYDVTDVAVNRRQLQAANAELQRLSSTDRLTGLYNRGHWEEMLRLDYARH
RRYDSQAALVMFDIDHFKAINDTYGHQVGDTVIQQVAELIRENLRDSDVAGRYGGEEFVV
LLPDTDKQGAMTFAERLRHAVESREVQHEQHRIRFTISLGVADLSVPTHSHAQLIEWADS
ALYASKAAGRNRVTLHQH
>A0A2X4XWK3|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5W1J341|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X2I4T1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLGAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGERSRQFNQPFYLVFARRTDRLYSAGIRNRNYPHPPFAQW
PGGSTEKYHRCRT
>A0A746H882|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLYRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y4X5D9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A742SFE9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNCICASDATQEREKK
>A0A1B6VNB7|diguanylate cyclase|EC 2.7.7.65|Gluconobacter cerinus|TrEMBL
MTVDALLSNSKQLSPDEVEWQLIIDAIDPGIRSAVADMVENHAAASVEVFYSTLLTHPEA
TPFLSNQIVNDHLHSALLRWLQSLFSSTAPDLAQLVATQRRIGLVHARMRVPMHVVMHGA
RLLKNTLRKLLFEIFLTPADLSTAIDYIENMMDLAIEMMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREVQRAALLDWGHKILLAICCNAPPPLPSLESSGFGLWLNHKGSLLFPNTM
GIEHIRTSMRRIDRVLIPALSAQVPPDTARIHELQAQIEEIRFLMDDLFKESEALESGRD
PLTSTLNRRFLPTIMAREVAQSLRREVPFSILMIDIDHFKSINDRYGHTGGDAVLRGVAE
KLISSCRTSDFIFRYGGEEFLIALVETDIKRAFQVAEHIRENVTHILTQPTGSSFSVTVS
IGVATFDGHPDYTHLIEDADRALYYAKAEGRNRSVIATDALASLPQLQ
>A0A7W3BA12|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RHBSTW-00215|TrEMBL
MNKDLSQAPRPTFKKALRRISMISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSSAAEDTLATLGRQGQFSKAVVLDNQQKHFAAWHNNHLVNQEKISGVIS
KWLFPEPTVQPIWHQGKIIGELRLTALDKLISHFLGVSIIVLTGSIFLASCIALLLTHSL
HRGIVTALQSITDVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVRSSSALLFLDGDNFKYINDNWGHAA
GDKVLIEVASRLMTFVGKQHQAWRLGGDEFAILLRNVRTEAEVQALCHSLSEQFLQPFNL
HNGHTARLSLSMGYALTWEHASAENLQELADQNMYRMKHRRLQHTQK
>A0A517MFD3|diguanylate cyclase|EC 2.7.7.65|Roseimaritima multifibrata|TrEMBL
MFEFFVALSCGFGGLLAGCYLRGITHHSAADTVEAEPGAELDGAAKIAQDQSKLKRVAEQ
LRQVSMRVAADVDEHQSKVQHASRVLSGNQNLLDSDTILEAVNQLVRANEEMQIRLNMAQ
ERIQKQASQIQSAEAKAATDALTKLHNRRAFDAYIEKCQSNGSIENCVLMILDVDKFKSF
NDNHGHLAGDEVLRRVSTILSVRLSDVAFVARYGGEEFAAVFTGKSYEECQKIAEETRCL
IGTRSIHFEGQDLAVRASMGLAKWNPGEERNGWIKRADSALYHSKQTGRDRGHWMDGNKP
RPIGQLKTEPASENSQRLSVSLKTKEQAIVSTEGAPNAVTRIPAEPKMREMFSELKARLQ
HVSVDLFVILISCDQEPTKAANHPHILRVTRATVRSLDHVGKSANGDLMVYMPSADVRGA
IDRADRICQGIFSATQSSSGSPITVSIGITWVPDNESFDEIRSQAEKAVTKARQAGGNQV
VVQGCPA
>A0A5H7F8Q9|diguanylate cyclase|EC 2.7.7.65|Salmonella potsdam|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A853SB46|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MLPLHRNSLIAAALALPLFLFLYATLGHLKPFAIWKWMDIVCEGGTAVMAGIWFLFTLSS
RPRGLVTSLIAGGLCAIMLGSWADCLDEFFAVDKSAVWDNWLEALIPFGMLVLTIGMYYW
RQEQFRLNEHLQKRERLFRDHRAFDRITQLADASYLRTQMRLEQERRPGLDCALVLLDID
SFHLINREYGHREGDRVLQAVGHMLLLNLRNDDLLCRYAGDRFAVLMPGVSREDAAVKAR
HLCAMVGQMRHHANDNREIRLSLRHACSLTDGVPEVVLAELSRAVETPRSGAGISSAAPA
>A0A377QBK8|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MRVPDLSSLRRVAVPLAFGGNSEQQHTYFAELHRVGMVTQALGIIAFSLTWLLMPPAYHP
NLTHAVLALLGMLISLVVRYRCTTLPVLTVTGACAVLALTFGLRTMADAVHHASFWVLPV
GVFMTLAIASIFNGGLSYLAVVAGVWWNVGHGLYPVNAGLPDQSWVPLMIAVSVLFGLAL
NVSFSLLRLRNYHSKVELTRLAFQDSLTGLNNRRMFTQRAQQMHGATHGGKLHFLMIDID
NFKIINDQQGHDAGDAVLVRTAAVIADKAQGHLCGRLGGEEFGIVYAGDREDARAFAGSL
VEAVSQAFLAAQFVSISVGVAELDRSKDLGHSYRLADEALYLAKRQGKNRYVIA
>A0A120JWV3|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MPVPVFPDDARLLGALASGSRGLINARFWGDGVDALLDELGRASGASRVWIFQLLELKQE
GVVQDYVFEWAAATHYRQLTQKRFRFFSTLFNDPVYQRIVAERQRGESQCFITSEMPSGS
LLKNLESQGILSMVTVPIMVDGQWWGTLGIDDCERRLEWQGPGLQALVVAAELIASAIYR
HQLTSRRRQVELFQQVADCGIWEVDPHSGSTWCSRALLNTLGYPDQYARVPLRRLLAHIL
REDRLCFWSQLRTCLVDASKNLRLDVRLISKNGDTRWHEIVAEVVCDDSGRLEALAGLVI
DISQRKQGEERAMIAAEYDELTGVLNRRGLTRHLAETLGGVSEPLPPHHLLLVDIDHFKQ
INDAYGHPAGDALLRLLAERLDKELRSEDGLARLGGEEFAIVVSGLNDQQVMQVAERLRG
RIADTPFPLESLPAKPPSHQVGISISIGVAGLSVGQDLSHSQALAMAQADQALYAAKGGG
RNRVVAYWQQSRERQTSRASTTGAEPGTAQ
>A0A853HAI9|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIAGFKAERDKPECTLPTGRDLAPEIQ
GVSDTFICQSTLLERDDALLYSELNATLALGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTASIPLDDK
GRWFGVLAMDFPIGAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTAEGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A0X8HB85|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MAVEPPQQTLQSFHDALMRHPLIRELWNHFPENMFLVRVEDDGHFTVEAANPAQLDTVGR
ECLGQPLPAFMPAASAEAIYTRYRECVARDKPMRYQEHAVFFDEHGNEQYGYWLTLIVPL
HNAAEDPQRVTHIFGISQDVTELHQAREALERHNQALEARVEQRTAELQHANRELRLLNA
QLEEMATRDFLTGCYNRRHIETLGQREIERARRYDTSLSVLMVDLDAFKQVNDTQGHDAG
DAALKCVAASLQNALRANDLLGRFGGDEFLILLPESNNEDARVAAKRLQQLTHEQTDITI
SVGIATLRRDDTLESLAARADQRLLAAKREYHRKASG
>A0A0X8HHJ8|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MTQQHEFPEGDASPDAWDHIDASGSPGTLVQSLKHFYTAVEHSPMATAITDPSGRLLYVN
LRFVDITGYSRDELIGKTCSLIKSGKTSPETYRELWQTLKAGNIWRGEMLNRRKCGEEYW
EYEVITPIKDEHDKVISFITVKEDISERKRQEEELRLLATAFETGQATLIANAEMRIERV
NQAFVNITGYTADEVVGHTPRMFKSGRHDASFYAGLWQSLTVKGHWQGEIWNRNKRGEIY
PVWQSITAVKGESGEVRHYVSVFHNIAERKQVEQALVHEASRDHLTGAANRRAFDRSLIT
AVRLAEKEGGEFAMMLFDIDHFKAVNDTHGHDVGDAVLFALTDCVQRRLRKTDLLARWGG
EEFTLLLSGTPLNGALQLAERLRSDVASAELPGGAITISIGLTLYQPGDTARDLLMRADR
ALYRAKQGGRNRV
>A0A5E5QW79|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERALSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEGNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G7AXJ8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLXLLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G4AH87|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRLQPFATVLDQLRSGLRRQELG
>A0A8F9JEY5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGTPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPMRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>A0A8B4ZHW3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLVAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALVNAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2X1XTW4|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MLKMMNYIKIPLFIFLVFIAFFSKDQNIIKRNISFENRKELIELQGYCSKEECRIINNFL
MLPIEKYPSEYKAIAEDIRNILHTKQGARIGSYILETMNNYFDENIDAKMYLLLKISTLK
RLSDDLYGMLIPTIEFLSLAKKSGDEYMISVGTVNLASILNFFDGYHTSNQLLNAVPISN
FSDNKWNRLRIRSQLIIAENNIAIGDYNKSSKILKNIITQDNGIPSNEWDDYHSYILALQ
ADIAMHFNRDDEARKYLDQANSLLNQDDYNFLVDKHTVIKTIELKWAIKNNINVYAKLND
MKFYHDNSAIISSRYLKMLYESIFDYYFESNDHTKYHELRKEYLSKIEYRMKLSYKLLYN
NSIINVNNDLLIDERDNLITKLKYSLAIILVITLILILVFIKYILINSENLNDELTKIGN
RKKYNRDIKKLGFNVYYLVLIDIDNFKLINDRYGHDVGDYVLKKLSNVISHLLPNNSEIY
RIGGEEFAIIFRGCHPQNIVDIMNHIRINVENLSWNSIDKVTISIGIARSDNSKDVYKKA
DELLYLSKTSGKNQLSIEEDYI
>A0A822IYH5|diguanylate cyclase|EC 2.7.7.65|Methanosarcinales archaeon|TrEMBL
MSQTKVMVVEDERIIAEDIRRSLLNLGYEVSSIVSSGNKAIEDAEKYHPDIILMDIVLKG
EMDGIEAAGHIHRRINIPVIYLTAYTDEQIMERAKITEPFGYIIKPFNERELHINIEIAL
YKYKMEKKLMESERLLSATIKSLGEAVIATDTEGNITIMNPSAECLTCWKQEDSMGKPLM
TVFNIICEDTGRQVENPVSQIIREGIFYGFDVNTVLKTKEGSVLPVDIIGTPIKDNNNNI
VGIVIVFDDITQRRQMAQMLRENSGH
>A0A1V5WEF7|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MISLGLTLTILDFQNGRNLTSVFLASLGVTVMFSGPLIAYILTSGWLLGMFSIAYLRFFH
TVADSSLIVTMVFLASLIFVFGLYAEHIRLKANLSAVRMRDLTLHDQLTGAYNRLFLNEY
IQKLISAKNRYGTTLSCILIDIDHFKDINDTWGHPVGDRVLVTLVGTVREQLRDSDTITR
MGGEEFLILLPETPLYAAMIVAEKIRRITEKIPFNGFTLTISLGVCEIRDKESFESVFRR
CDQALYRAKDKGRNRVESCMECSPVTSPSK
>T0PDU8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLKLSEFWSARAHSEDFTLTRMGFMTVRLRLLTCLLMVGLPAWALVDWLTLPAAQFDALL
QARIFCLLALSPLIPFSYLIHFQRERMKWALGYLMTVMLLFALICLHSFGADQELQAGYM
AFPYLLISLFAIFPIPLSLSLQLTGGIMVTTLVGNWLLVGQPLWSMQTLNQVWLLGLFAM
TSAWVQCGQLNMLLQLYRESTTDELTGMMNRRLLMKQLDKARVTMDHKHSPFAVMLLDLD
RFKRINDTFGHLAGDAVLKEVAATLAEQLEPGMVLGRYGGEEFAILLPRCGELAQAKRVA
ERLRVAVEARLVKSPTSDELLEVTVSIGLTLAQRGESVEDLLNRADECLYMAKMAGRNCV
VGELAGGPGLHPPAKTDAA
>T0PID0|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKRYLLWLLLIGASYIGPLLANESSLEAPERVVLQLRWLHQPQFVGYHMAKAKGFYAKAG
LDVEIRPGGKGISPVDEVHSGRADFGVGNTEVLTAYANGKPLLALACVFQHSPSIFLARR
DSGILTVDGMRGKRIMMFSAHQDAELLATLFYQGLNESQLTPIQTSVNIDDLIEGKVDIF
NAYLSNEPFYLEERGIPVSVINPRNYGIDFYSDILFTTQAQEQAHPGRVERFRTASLEGW
RYALAHPQEAIALLRSEYGVNRSQAHMEYELQVSKEMIQPLYVEIGYMNPDRVTHIMEQL
TEIGLIKRPVPLADFLYQAPSEQWVFWRPWFLLSLAACVLILLLAVYLLVCNKRLNREIA
LRQQREEEILQLARRDPLTGLPNRLSLMERLEAQISSPNPGCLLFCDLNNFKQVNDGFGH
SHGDAILCQLAERITRSLNHQRFFARLAGDEFVLLLPDHDLIDAEAIAEVIRRVMTAPFQ
VKDHQLEVGISVGVSQYQPGWRAEQWLIHADRAMYNDKGIELAVAPP
>A0A5P9FCQ7|diguanylate cyclase|EC 2.7.7.65|Sulfitobacter sp. THAF37|TrEMBL
MNVPLDLSFLDVLCPMHLVVDAAGHILHAGPTVRKLSKGMSLIGVDFLEVFAVNRPRAIA
SFRDLRLSQDTKLHLEMRAPPQTALKAVLVPLGDAQGRMIVNLSFGISIANGVRDFALSN
ADFAATDLAIEMLYLIEAKTAAMEESRRLNHRLQDARLVAEQEAVTDALTGLANRRALNG
VLARMAAGRVPFAVMQIDLDFFKTVNDTLGHAAGDHVLRQAARIMREETRETDTVARVGG
DEFTIVLPNVADAATLRGVGQRIIDRISEPIPYDGHLCRISASIGTVWHPQGLSQGMDRM
IEDADLALYSSKHAGRARHTLYDASLRGVTLDRREQSSA
>A0A157SLX3|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MQAAPTPADERARIAALRSLNILDTLPEERFDRYTRMARRLFGVPVSLVSLIDTDRQWFK
SRMGLELPQTPRDVSFCAHAILSDDMFLVPDARQDERFHDNPLVSGDPRIRFYAGCPLSA
PDGSKLGTLCLLDFEPRVMDEENQGLLRDLASMVEEELSSLKLAGTDPLTGLSNRAGFET
LAMHALSFCQRMEKSATLLFFDLNEFKPINDQFGHAEGDRALVTFAAVLRTSLRNMDVIA
RLGGDEFVVLLVDAGAEDVERIASRLREAMDEKNRSLNRGYAIKYSVGRTTYDPQRHASV
QALLADADAAMYEQKRLGKAGR
>A0A174KHK1|diguanylate cyclase|EC 2.7.7.65|Enterocloster clostridioformis|TrEMBL
MSGKENLTKIEFINQNVYHVRSTYVEVDGYPYLLELVDQITEETLLGGHGRDEVIKYITV
HDFRLYVDILTGIYNRRYYEEQLRDMSHVSAAAMIDMDHFNAINDTYGHPVGDLALKQAA
KAIKNCVKRTDSVVRFGGDEIFVVFGDIPFHMLQEKLEEIRSCVDKAVIPDYPQLKLSIS
IGGVYGPGQVSDLMEAADRLLFQVKREKAGLKIKEKMNERL
>A0A157RRP8|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MHGLNEYAMRDALREQARLDALTDLQVLDGGPDPVFERITRLARATLRFPIAYVSMVGLH
HEILKTRTPLPVSTGSRDTAFASYALQSAEPMVVPDTLEDPRFARFPQVAGSPYVRACWS
MPLATRAGLLVGALTLLDYAPREANAEDSAILKDFGRLAAESMELRAQASTDVLTGVQSR
RAFLGEGERIFNSRHPDRHALSCVILDLDDFRRLNDTLGYEAGDDALRRIGELLRGGVRP
DTPIGRVGGEEFAILLPGETLYGAHTVSERLRHALSQLSDQGFPGLSASCGLAERGSADR
GFTDLLDRASQQAYVARHAGRNCTRPDLAHISGQAPGFRHRTPI
>A0A2X4YQE5|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MSDFLLARVSQTLANEHTLETLVRQLLEMLELVTRMESTYLTRIDFEAQRQQIMYAHNSS
EMQIPEGFSVPWNDSLCKRALDDRCIFSNDVAERWRSCIAAQDLGIATFFSIPVRLTDGS
LFGTLCATSRERQPYNIEGEQVMNLFANLISHYVEKETLVQQLRAANVALEMHSYTDELT
GLPNRRSLFKHLAAQFAQARERQRSVLLIFIDLDDFKAINDRFGHPCGDSFLIQVGERLL
ARARRGDIVGRLGGDEFLLVGLCSEAEEQQEYIAALRKELTGIYFLGAHRINYPGASFGV
IEADPQAMDVEQALRSADDAMYQDKKSRRQGTFFHID
>A0A1A6B4G4|diguanylate cyclase|EC 2.7.7.65|Clostridium ragsdalei P11|TrEMBL
MKFLYKVILMLGILIALSCFVQFVVFNKFFISNTDSLLLSTNEKASKDVSMQLVENFNKI
QNFVKTVASDEEIRENQELLDKFNEIIPEVDVVTILNSKGDILRMSGNVHSPSVSNLAYT
DYFHQAIHGKTYISNVFTSASVTKVVVISVPIVKDGSIDGVVAGTVELQGTSLASMFDNK
KFGRSGYISILDSHGYVVYHPDKGEIGKKSIVFGKLQGKSGSKIMKDYSGKDQFVGFSKV
PNLNWYVIVITPTADIMTSRNIVVYETFIGSVIVGILIILLGIYTIKRYSKPLDKLIFSF
NALKAGKYKKIDPYNYGKEFQEMVRVYNHTIERLEEEYNDLEEAADIDSLTGAYNRRAFN
NLLSILKQEISNCSLESLGVLLLDIDRFKELNDTSGHLAGDDILKKLTQIMKSTAGDRSV
FRFGGDEFAVVIRNVSDERLLAIAEVIRLKGEEALNGCTVSIGTAKYPKDAYSIDKLIDF
ADKALYISKKSRNKVTTFVK
>A0A174CXC7|diguanylate cyclase|EC 2.7.7.65|Turicibacter sanguinis|TrEMBL
MKNYLFIFLIAICSMINSGDDFCIEASSVFNNSDEEWLLEKSQSKFKIGYPSSITPLNYY
YFYSSLKGVINDISQEFSNLTDKNLSSYLISDIAENESLLKYGIIDLFVSGKMEAYKEFY
YSSPIHEFEYTFYVNQGNNAKNTEDLMKYKIGIVNNDDKIEKYLLSFKDIISYPNYMALY
AGLNNGEIDAIFVPRDLFQYQSLVHELREVKSTEYLSSAWYFISDEPNLISIIDRIMSKM
QTMEKHADYFFNHQNALIGKLYNLDKSTYEWLFYRQPVIKVGIYDVPPFMYYNEDEDTLS
GMLDYVLKQIHNNFGVKFEFVFGDYEELVGAYQQGVIDILPVFEMESNEKLFLEGNNYEI
YQGQINAYGLFNQVMFQEAVGTNLNTVLGSVSSEGFLRSEMNVRVEDSISKLHEGLVERK
IDYLLLDPVYLDYFEQYNLSYKGKIGKYIFSLMVRDNQNFMTLFDAIKVHDFEDDEVRLK
YEMVLSSEMYLFEMSSLNHDLYLMHQQQFLFAGGIILCTSIILVLGRMRYLDKKTEHLKY
TDYATGLLNRLGYMNQMDKMMNKGEPFTFAIMDIDHFKSINDTYGHLVGDQVITYVANVL
KKCCPQNSVICRLGGDEFVICIRDHSKEVAISVVESIREDLKGYSEYFEVTVSIGISFYR
GEAVDLEKLYQQADHALYESKKNGRNQYQIFQN
>A0A730ZPW9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 1,40:z4,z32:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAALVFSDNAAAEETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFAGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRAERSLN
>A0A173T0E3|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MMEGITIIVLEEILMANGLTVLMMWFLLFCRRKNRESLHVGDKIYDGIAIVNLVGALSET
IAFLVDGKQFTGSRQINYISNSICFIGTVSMGMLWCMYVELRIYRNYKRMVQKAGVEIFP
WLVEVIMVLCNLFGTGIMFKISGENVYQRTAGVLVGYISLVIYFAYSIYLVYHSKKQGVN
LNFFPVIYFVGPCFAGVVLQFLFYGITSSWVLVAVALIFVQMQSYAESLYMDELSGLYNR
RYFNAVLAEKKIASHKSLYGIMMDVNDFKCINDNLGHSTGDKAICTLGNILIRSIPDDGM
AIRYAGDEFIVLLSGVDTERVLATMEEINHNLSRFNESGMEPFHLRVSMGYTEFGTEDDA
ETFLMHMDEKMYEEKRKYHMRKKSASLENKV
>A0A729KZK6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kouka|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRIRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7H4PAZ8|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVKAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
TYDLVQERLSSSLAGWVKDILMCEKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSHLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENSAIFNIVSDNKTDINGALLSDSEFGLWFRHKCVRYFNKNPQM
EEIADLISKVDALLSAWKSSSDGSEYKNTQALLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDSLTSLLKPPLSAGCPQA
>A0A3A9JL55|diguanylate cyclase|EC 2.7.7.65|Roseomonas wenyumeiae|TrEMBL
MNAPLASDLPDEAAASRWEWESLNGSIPEELRRHIAEIVAREAGMLTALFYDTLLKDPEA
AAMLSHELVSHRLSRSLQRWLVDLFPPDAAPEFADAARLQRRVGEVHARIRVPLHLVTRG
ARVLKGGIARCLSQTSLPRDALVETLSYVSHILDLAMELMATAFIQGTERATRNEEAYRL
FSLGQDASLEREAQRAALLEWLQSLLFAVAGRNEATRLQPIGRSEFGLWMQHRASVMFGG
IPALQRIIQLMREIDEEILPGIERGNGIGAALQRLQAHANDIKFLIGDAFQAVIGLENGR
DALTRTLNRRFMPSIFAREIALATQSGRGFAALMIDFDHFKSINDTFGHSGGDVVLSRGA
ELIMDAVRLSDFVFRYGGEEFLVLLVEADANLAMRTAERIRTAVEACHFSVGEERSLRVT
TSIGVAVFDGHPDYTHLMERADKALYAAKKAGRNRTILG
>A0A174HTZ8|diguanylate cyclase|EC 2.7.7.65|Fusicatenibacter saccharivorans|TrEMBL
MSLSDKDYQKKLDVQIAYWDKLKNEIQKVRSGENGTADLVDMSETYFQMADETVAAVKVS
HANRQLEQKAYIDLHTGLPNKSKCEELFHNVEFIKTPTACIVFDMNNLKRVNDSLGHSIG
DQLILNFARLLRNSIPAKHFVGRYGGDEFMAVIYDATRESITEILTELQNEVEQFNGYGT
QFRISYSHRLALSTDYNECTLRMLFDKADKYMYENKQQSKQGRQD
>A0A0X8NY53|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNVQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHKGMKGWLKGLLCVREQGDIAALMAVQKKVGEVHARVH
IPIHLVMAGARILKNEIALRLRASDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPGLLQADLAGLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAVNDQHGH
AGGDQILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALLVAEKLGAEIRRHAF
TIPEVGTLRITASIGVAAFDGHPDYAYLIDRADKALYQAKQLGRDRSVAA
>A0A3S4SEN4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MGDGAVGSLLRQWWQQSDDYQWRIDFLRSRGLLPVLRWVIAGIGATMGVLSAANVVAPAG
ADGAAFRIGWAVVAVGSLGWAARWAFRPWPSARESAALVVFVDVIMTLSALLFGDPNLAI
SGITILLCAGGYVVFFHGPRLHLAHIGWCIVSVVGIAVWLAAGSGEYGLQVGVSRAVIAL
LVTVCVLPALQFGFWLLQGSSKQSFTDPLTELTNRRGLEVSMKRLNEAARGDAQLCAVMI
DVDGFKEVNDTLGHSVGDDVLIRTARRIRESVRDDAVVVRWGGEEFLVVDRIPAPQAETV
AERIRSAVSAPAKPAITVSIGVATCRPSESALGDVIVAADSAMYEAKACGGDRVIVTSAA
>A0A446CGJ3|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MRSSSSNDAAGAQALPAEDARILSVASGILGVEPDARYFEMLVRRAVEDMGADYAWVRLD
SDGSADLIASTSCRAGAPAGPEGAASALQSRLADGASFECLDGMSGNHPWIAQAGVRACV
ARNLRDLNGAVCGHIAFAFKQAPASVSAYADVLAMLGAFAQHAVLPAMARKRELTHLRDV
VAQYEALFQAAPVLINAFGPGGQCTLWNEACERRFGWSEAEVKAYQDPLALFYPDPHIRA
QVIDSVGPQPSRAFREWHPCTRSGERLAVLWSNVRLPDGMVVNIGMDMTESRRTEAALAR
MARVDSLTGCWNRAEILKRVEDRLAGARRGEGGLNTALMLDLDYFKQVNDRYGHLGGDTA
LRHFCDQLRACVRDGDSIGRLGGEEFLVLLIDADMDVAHAICTRLRMSLRQHPVDIDGEA
VALSVSGGIARFADGDASASDVLRRADFALYQAKRAGRDCAVEYRV
>A0A075R764|diguanylate cyclase|EC 2.7.7.65|Brevibacillus laterosporus LMG 15441|TrEMBL
MRYRYRGAGIGFLLGCLWWWLGAVSQVSFQSVYVPFFLAVLQGACGFYYGKKLEDYKKQA
HHDSLTEVLVNRQFFKMMDREIQKAKIHEYSVTLLVIDLDHFKKYNDEHGHLEGDRLLKR
FAGFLRENVRGNDLVGRWGGEEFVVLLPHTCLEEGVDVGLRLQNKIRQEVGEVTVSIGVA
SYPDHAATATELTAYADQIMYQAKKQRDCLYSGPVGGEIKFWHRDTNHIPLH
>A0A8H9AHF0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLTLTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8I0FJ27|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. C1|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVQDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRPGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A517Q0U6|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MNSPQIATSQTVPQQQQSVHGSYNMGSSQILRELIAFSAESDEIALETRHADEIDQVICR
KHLRKLLTALQARDAATLSHCRRVAFLAKGIATNLGWEGIHLKRLEVAALLHDIGKIGVP
DHIIFKPGKLTSDEIELMSHYHHIGLDVLQACRTDHEVLTILSQTRFHFSGATNGYQCIG
SDVHQGARILAIADAYDSLATDQVYRAGKKHEEIMSILMGAAGTQFDGNIICALSRWEQT
ERDTFHEAIQEVNQNFQPKPLTEQEISEANLISNIFSYLFQIESLYDGFYIVNADFQFVL
FSPGLEQLTEIRAFDILETAWTNHSLPITNQEGTSLASSEHTMNRVIASGKSMTTELMLK
RPDGRLIQIEVQSVPMFGEDGRLVGVAEIFRDLSRSLKRPQEFNELKMAASQDALTSVAN
RGELETQLAILLNQASQNQNAAPLSIIFIDADHFKNINDTYGHAVGDEVLIELARLFQHE
TYSGELVGRYGGEEFVILCPETDLDHARLKAERLRLAVNNLKLDNLNNNRITASFGVAQL
EPGDSLESLFHRADNALYQAKETGRNRVCSLTCDEQMSGAAPDIVEPAQPNVGKMVFESS
FSALISSDIVVYKLGGFVNDNDARLTEVNPNRAVMRLGKAGLLPFWGKTDDRRPIEVELV
FDNATKKSTSASRHATPRVEVMIRMTPLGWIKQPDVFQQRATRVFRLLKDYFVAD
>A0A398PZ20|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMFGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A823B7W7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
RHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINMLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2X2IVD0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGISPV
>A0A7G6K5H1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIMEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A518FHR5|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKDPDTDIKEVIDTIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITHGPLKSRYDSYWKQSIIQSAAAEL
LSSRLGNELKYDAFLIGLLQDLGHLAMLRSIPNDLLPVLEQAETEQRETAEVETQVLGIN
HAEVGVKMMERWQMSEQFQIAIQHHHDTFEQLKALETDPNFNLIIIIAASASIGDYFCSP
NSGLALQRLQQLMTEFYNMPSDDLHGFLEEVQSRFEEAAQIFQVNMDDIESPYEIMAKAN
EQLVQLTMKAQVDSTQAFARQAAIEEQKVKLESENKQLQSKAVHDPLTKTYNRSYFNEAF
EKELHRCARSAQPIGIIFSDIDRFKNLNDTYGHQFGDLVLQRVAKVASESTRRSDVFCRY
GGEEFVIMVNNPSENGIRELAERLRKLIENEVIEFEGKRVPVTASLGAVVGIPPRDMTGY
GERLIAEADEAMYNSKENGRNQVHVRSIITQADNELQKLIKRSRFSRWLVTKKIFDIPTI
SKALLKCPQQETQTKIGELAVNEKLLTTAQVTEILERQQQNGERFGEIAIQKQLLSREQV
AYLLALQIEPPIVLGKTLISLEMLQSAETAELVKLYLSEFKASPAPIEERRSDFANS
>A0A2N9MGH7|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MYEEDDRDVNVLKSVLPLMSRHAAGYHPISYTVWYEYAKGQHTALHQSVDDELKRQERLS
VAQTYFLYTKHLVEPAEQALMTARSGLLDLAEQVKKAVHEVDVDTAGFDTHLNEFQHDLT
SAKTIEDLGGHVSTMLAETRRVSEGLGKLSTQLEQSKSEVRRLTDELHRVREDSQIDALS
GLLNRRGFDRELQRLFPNAGTQDGALAVIMLDIDHFKVINDTYGHPLGDAVISVVGHLLR
ECVGQLGVAARYGGEEFAVLLPERPVAAAEDLAQLIRIRVEQGQIRRRKGDAPIGGVTIS
AGVAAWRGGEDAGSLVERADRALYASKRAGRNRVTVDAG
>A0A6C7I149|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A (strain AKU_12601)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3D1C3F5|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
TVITSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVV
SEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFF
RSGNAYEVERWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILA
NTDSITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVS
LAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCS
VGIALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKAL
ENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVIL
DVVRQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLI
ENDELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQ
SLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRY
LKRA
>A0A378BHW6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPSFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A358FQN4|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A3D1C590|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MRQDAEVIMKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHVWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A0R3JWJ7|diguanylate cyclase|EC 2.7.7.65|Caloramator mitchellensis|TrEMBL
MKVSKKLFKPYLYLIFTLGTAISIYYVANIKSYAFPLVSIFFMMVTVISEVFDYDGEAND
DELSFSLSISNIFFLILMFNAIIAITSNIIAFLIKGLKLKMEGRYNKILNIKTMFNISQT
TIIIFITEFLSKKLDIDLISSRDILKLAILILIFDVLNRLIVSLVISFHSGKLFLEAFKF
KMFILYNYYSIILTFALIFSYKGYGLLGATIVYLMYIPFQIVTFRYTKLKEKERELFKDR
LSGAYNYRYLEALINSKISKKEQFAICMMDFNNLKYINDNFGHVTGNQLIEFFAKVVNSA
IDRNTVFCRYGGDEFCLIHSDYDELKLFINSINELLKTRFIETNGTKIYTSVSSGLYKYT
GEEVDFNFIIDKVDRAMYKSKHKKGSEIVEAF
>A0A483LR08|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEEWGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A377TJM7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMG
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQRSISIASTSAASWECYSVVCRRCKTA
KTH
>A0A2X1QI00|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFAL
LLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNSVTAEACVQRADEAMY
EAKNNGRNQVIVWHRQGG
>A0A486R0P2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLTA
VARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVV
TCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A2X3DA58|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKEL
EFSAVHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGHPKRR
>A0A862ZJ75|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4Y7RQH8|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum propionicicum|TrEMBL
MIEHTQLFAKAIEVLTQPFVARLLDGSMLMCNRAFCDITGYSEKELRSMKKKHGLVPPGW
VDYKTKALEELCRTGQPQRFEIEYLRKDGSHLPVEILIYLVNGADSTPLYYYMFVNDITK
RRQAEEALQLSEERYRQLIENAPLGIAVFDTKGQIKTVNKALMQIFGTPEDEVMRINVLE
YPPFVQAGLPGDIHKCMETGETVVTEHPYTTRWGNNIHLRLHLTPLRDTNGVINGVQAIL
EDFTDRKRTEEELINAHQKLMDIIESLPDATFVIDKDRKVIAWNQAMEELTGTPKAEILG
KGDYAYGVPLYGEPRPVMIDLAFGEDKQTEEKYDYVTKEGNIFYAEAFLPAVRGGKGAYL
WGKISRLYDREGRLIGAIESIRDITERKRTEEQLKYLSLHDPLTGLYNRTFFEDSMRRAG
DGRFSPVGIIVCDLDGLKFINDTLGHDAGDSLLENAAAVIEGSFRQSDIVSRIGGDEFAI
LLIHSDEKTVEDACNRLRHAIDRYNEARPEIPLSISMRFAVSTQSDHGINELFKEADNNM
YREKLHCSQSARSAIVQTLMKALEARDFITEGHAVRLQEFVTILAGAIDLPKRNISDLNL
LAKFHDIGKVGVSDNILFKPGNLSSEEAAEMRRHCEIGYRIAQSAPDLAPIAEWILKHHE
WWNGKGYPQGLKGEEIPLECRILAIADAYDAMTNNRPYRKAMTHHDAVRELKRCSGTQFD
PHLVDKFVDVLSKSARPEKT
>A0A4Y7S9E4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. FP|TrEMBL
MRPKEGFFHFTTSWLVVILAVWQLCRLFPSLDLDQTGELLVIVFLGVLAELLAVSFPHGQ
LSGSFTLIIATFLIYGPAATAWVSGLATVFGQGIANRGNPLRTTLFNTGQYVLAAVSAGW
AFYLCGGAPGMVSLPNALPLIAFTVAYIVVNHLLVYLYLLPQRRCMPHLAWLDTIKWDGL
TYLFTVPLGLLVAMIYPFVGMAGALMLFFSVLGLQVILRFYVRLQVTNKELTAFYETARY
LEENPGSVKILEQVLTNARKAIHYHSAAAYFRSGERDTYLPAAIDGPYAKQLGSTAVYTG
EGITGSVVANREPEIIYDARLDPRTRSDTGLCQVMRSLIVAPLCAGGETLGVVVLGDKRP
LAFDQNHLHIVAVLCSQAAVAVENSVLHDRLGQVLSHDTLTGLINFSSFAELAAELCDSA
GEAGYPVGMVLVDIDRFKNYNLRYGRQAGERVLAELAALVEEDARRDDLIARYGGDEFVL
LLPGAEGARLMGIAEDLRVRVREHAFRRAGGVSTRITVSVGLAEFPRDAGDLTGLLLAGQ
RALDKAKEAGGNRVVAAAVSIVE
>A0A3N2EL04|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. BIGb0359|TrEMBL
MPGVLLARRVDVRGQYQGAYVRRDNRVKHPRWLAQLSQQSRPGRVVNLCFIIVLLLSTVL
TWREVAVLEDAYVTGQQTSLVNVARAFDAHMQLSIDDIRIYHDSMPEAINAPLPFEALRH
AKNDFDALRKLPEWVISLDVMRTIPVKGVSDAFVEETHLLSRAHPWLENELTATLELGYL
MYLSRHASRFAWRTQYISRAGFYLSSEDLHNTDGTDILSSYYSRESEPWMVEQTPQANPS
RKLRWYSAMTPEVTLTASMPVDYRNQWLGVLAMDFDLSAINTFLANAAAGEGDGRFQLYD
RHMNLIAWSGDVVTLSERENARLAGAIAKKSRGGIRFTGGYVSWQRLADFDGVMLRFHTF
GEGVRSDFGTISIALTLVWLLFTSMLLISWGIIRRMVLNMSEMQRSLEWQAWHDPLTRLY
NRGALFERARQQTNLCQQRQEPLAVIQLDLDHFKNINDSWGHQAGDRVLVHVGGLIGSSL
RGGDIAGRVGGEEFCILLPGTDLADAYQIAERIRQRLNSKEILLSRGTTIRISASLGVSS
SEEHQQYDFEQLQSVADNRLYRAKQQGRNQVQATD
>A0A2R8B3J0|diguanylate cyclase|EC 2.7.7.65|Defluviimonas aquaemixtae|TrEMBL
MDGGAACSDPALLNAAALGRLMPLSVWVAPTGHIRAVGPTLAKLCTGQRLEERRFLEVFE
IRKPQTAQSMEDVRRLVGRRLDLKLREAPRTGLRGLCVALADGQGFVVNLSFGISAAEAV
SKHGLTNADFAPTDLTVELLYLTEVKAAVMEELAALNRRLQAAQRAAEEQALTDALTGLA
NRRALDLSLAAAIDRAGRGGAPFALVHLDLDHFKAVNDTLGHAAGDLVLGHVARVLRGVV
RKHDFVARAGGDEFVLILAAPVESMLLERIAARMIAGIEEPVEFEGKPCRISCSVGGTIS
DLYDVPDADRMLSDADTALYVSKRQGRARSTIYAPGLSVPEDGAPATDSVRR
>A0A2X2DLQ1|diguanylate cyclase|EC 2.7.7.65|Proteus mirabilis|TrEMBL
MSELVINNNIVNDLLIKQFTNYVFMMIVTDIKGNIIYANKKYCQFNHIDFESIKNKRYNL
FYLVDENQVLFSNISDNKEVIRLEAKHPNKNKQEVWEDINIVPIFDKNNLISHYAFLSLD
ITDKVKLRNDLLNKSYIDSLTGMANRLSIIEKIEQERLNIATPSSFCLGIIDCDKFKTIN
DQYGHAIGDHVLCEIAQRLLALERQQVYCGRLGGDEFAVLFPAGLRSCSLLLLEIIESLW
RGMEKTDKNQ
>W6K5P5|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MDVDTAVDTDLLKQTLEAVTNLVCLCREGSITYINTAGVSLLGALSKDQVLGRALADFVP
SEYGDLMRADMGAFAEDANGTPLKIHSLDGSVRDAVLSVTPLEGEPGTFIVEVRDISDFL
RAAHETQQQELKLRRIFESVADGIVAIDGRGIIHTFNPAAEAIFGYRATEVIGQSIDLFI
PEQDKGFHGSAIKDYRKRGHSDVVDNTRDFQARRKDGTIFTAEIRVTEIEEGRHRNFIAT
IRDVTEKRAQEEKIRRLAHHDILTGLPNRALLKDRLNRAVARAHRQEIYLALMYVDLDKF
KPINDLFGHDAGDDVLRGVAGRLVSSVRGTDTVARVGGDEFVVLIESLNAPEEAGKIADK
ILTLLLAPFRIKGADVHIGASIGISLFPVHGEAPETLMKRADEAMYKVKGAGRNSFVYAE
GASLP
>D8G7D0|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MFQESQTQPQQLKQLQHLPLHLLIVEDVAEDAELMVLALESAGVNFTWNRVATATDCEDL
LTNTTYDAVLSDYRLPGFNGLEVLKLVQQSGQEIPLILVTGSLGEEAAVECIKAGMTDFV
LKDRLFRLPTVLERALGEFKLRRQQQQAIALVQRQAKREAIINKIVQAMRSTLALDEVMQ
ITVDQLQTALQTTRCLICQVEISNQTRACYVSMSATNRENIIGVQCGFSTLHYQTLSQGE
TVIASEFDNLPPQIQELLRIFEVRSLAMIPLLYRDSFLGVISLHQCDRPREWSSEEISLV
KVIADQCAIAIHQTELYQKAQAELAERKRAEETVLLIQQQFAAIATNIPGSVYRIAIDPD
GKMSLLYISPGVQEITGISPAEAIARPESLIEIIHPDDKAMFDTSLQTSIETLQPCHREY
RVISTSGQVKWVQDSGHFSKDSNGNVIVDGVALDISDAYGELSLRKQAEEALRQREQRFR
SLIENATDITVILNASGKYDYISPSVKRILGYTPQIAIGRNALSLAHPDDKAAIAQTLSK
AIQNPGISQSPIEYRVRHRTGSWCVLEAVATNLLHDPAVNGIVINCHDITARKLAEQQLL
HDAFHDGLTGLANRALFSERLDHAFAIAKRRKDYLFAVLFLDLDRFKVVNDSLGHAIGDR
LLIAIARRLEKSLHPGDTVARLGGDEFVILLEDIDSLSSATNLANLLHQELTSPFTLDGH
EVFITVSIGIALSSPECEDAANLLRDADTAMYRAKEQGRARHEIFNTSMHAHALRLLQIE
NDLRKAIEAIKKEQYINSTAPKLQNSAATESNEQNIILSQLPITNHHQPITIPQFLIHYQ
PIVSLLTGKITGFEALVRLQHPERGLVSPAEFIPVAEETGLIIPIGQWVLRESCRQIRQW
QQQFPHRLSLTVSVNLSVKQFSQPDLIAQIDRILRETDLDGRSLKLEITESVLMENSKSV
TALLKELKARNIHLCIDDFGTGYSSLSYLHRFPTDTLKIDRSFVSRMGVESNINQGSIDP
TEIVRSIVTLAHNLGMEVVAEGVEKASQLALLRALKCDGGQGYFFSRPVDSWAAAALIAK
DEGDFERRG
>A0A8A4K8B6|diguanylate cyclase|EC 2.7.7.65|Pantoea ananas|TrEMBL
MIVETLASSDKSPKKWLNACWLGLASFVLTLFCLELIVVSGKISPLWFSTALMTIVVFRS
TSRQLPLLLIACLIGTALANAFIIGPAPSNLKFALLNLLQAILGGLLLRALLDREAPLVS
LNDWIRFVIATGLISPLVGGVLALWILQVGDQASFAFFYTWVISEIIGMLALGPVLLLLT
WPLSQNGLKRASLVETLITLALTLTASYLSLRFLPWPFTFILVVLFWCAVRLPKVEAFVL
FFVNASFMALLLSLGWINVTPTAASTYAVISSWLPFLMVLIPCHIMALVMDAFRHEKRHI
SESETRFRHAMEYSAIGMALVSAEGRWLQVNKSLCDTLGYPEHELTQLTFQQITHPDDLY
DVQGRLEKLLQGEIYSYTLEKRYFRKDGEIVWVRLTLSLVRDQAQQPLYFIAQIIDISEL
KQSEQVNKRLMERITLANEAGGIGVWEWNLTSGEVLWDKRMYALFGMKPHELPSYDLWVT
LVHPDDRERCVLTIQGAIEKSSSFQMEYRVVREDGQHWIRSQANRLLSKEGRIERILGIS
QDITSLRNLNEALFQEKERMMITLDSIGEAVISTDQDMCVTFMNPVAEKMTGWSQEAAAG
KPVNELLHITHGRHGPEVDNLLLCHVPSEKTAPYLSEEWVLHTLNGEHIDIHYSITPLKS
ESGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAVEHQNQ
HVLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHRLRGSDFLARLGGDEFAVLMPECS
LDQARDVVQDIVRAVGDYCFEWLGRAYQVGASAGITQINAQNCQSSDVLSQADIACYNAK
RSGRGRYKVYEQHALALMGSHHSVDLATLDALQVDMQVWAVAPPGKPHSASVWLVEVQLF
SPEGLLIDEHLLRNNLTDDMLKRRLEDNIVNAFFRQQIATMSQKGIALILPLDVHALYDP
AFVDNLCLRFAESGLARSHSGIALNASSVLSSGDGLIGALMKLRQAGCRIVLQHFGRNLD
AFNQLTGKVVDCLILSPELVANLHNNLMDEMLISIIQSQTSQRDITLLAGPVSVPAVLTT
LTSLEVDGVWGSAVAERQPMSRLAEAPLFAIR
>A0A3M2RCU7|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MRPNDPNNLPGLSSKDSLMLLRSTAELSFTSIVITDKQHDILYANPAFCRMTGYSLDELF
GQNPKILQGPLTDPLVIEKLRRGLKERGFFAGSTINYRKNGQPYLLEWTITQISDDSGAP
RFFVSVQKDITQLDAERSTGNLFAKAIEAAYDGIFITSSEGVIEFANQGFELITGYTPAE
VIGQTPAVLKSGKHDKAFYQRLWRHLHEGLPFRAMVINKHKNGREIHCQQTITAVKGANG
AITHYVSIIKDMTERVFDEIKLQEQASHDAMTGLLNRRRGEFELDTLLTQSDDSRSTFCV
LMADIDNFKAVNDTYGHPRGDEIIKVVADILVEHTRKSDKCVRWGGEEFTVLLPFCDLDR
ATRIAENIRTELAAMTFEDIGSVTLSLGVTESTAGDTPSQILDRVDQRLYQSKRNGKNRV
TSENAA
>A0A514V7L5|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNKKYQRVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTFLAPLWFPTSIMMVAFYRH
AGKMWPGIAFACTLGNILASWLIFSWASINFWYAGVNIAEAFVGALLLRKLLPSYNPLQN
LADWIRLAIGSAVLPPLLGGVLIYLLVPGDEPLRSFLVWVLSESIGSLALVPLGLLFKPH
YLLRHRNPRLLFETLLTMAVTLVLSWISLQFLPWPFTAIIVLLMWSAVRLPRLEAFLVFL
VTVMMVSLMIAKNPTPLATQYASAMINAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSVIGMALVSTDGQWLQANKALCQFLGYSQSELRSLNFQQLTWPEDLESDL
EQLEQLLNGEINSYSLEKRYYTRNGEVVWALLAVSLVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDVKPNVISWDKRMFEMYEVPAHVKPTWQLWHECML
PEDRALAEQVVRDSLAARIPFKLEFRIRVKDGIRHIRALANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVNMNVTFMNPVAEKMSGWLQQDALGQPI
LSVLHITFGDNGPLMENIHSGDMSRTDIEQDVVLHSRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRELSYNASHDALTHLANRVSFEAYLKRMLHTVQDTRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDMLARLGGDEFGLLLPDCNTESARYI
AGRIIDAINEYHFMWEGRLHRIGASAGITQIDERNNQASEVMSQADIACYSSKNNGRGVV
TVYEPQQERMLDAPGTISLDEQWHMIKDNHLLMIARSVASPRIPESSTFWMLALRLWTND
GEMLEEQAFRAGLAEPELVHALDRRILQEFFRNFATPLTSKGTGVALPLSMAGLASATLV
DELLEMLSASPLQPRLLHLVVHVSVLTLEDEHSRNNLDKLRQAGCQIILSHVGRDMEVFN
HLSAQMADYLLLDPELVINVHGNLMDEMLVTIIQGHARRLGIKTIAGPSNQPIMMDTLSG
IGIDYIFGNTIGEPQPLELLLNTTYFAIN
>A0A564UGQ1|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MKKIHTAVTLIIIFFMVAALYICGRYENAPDRIFTGKVSAPEGEWTIDASDGVTKAEVTF
SLSDRGEHEEWVLLLRSHWKNYYVRVGDETIYYRNGKRDGSVHLFDIPSGDSLTISFIGG
TKDNLKGIENSEILIGDKTSMYRRIIKDNLYAALIGVLSLAFGVMCIVACLYMKAEKTEK
IYRALRNLGICILTEGIWVVTDSQILLLVTQHTSIIEQISFLSFFTLPFPLLGFIKEIMP
GKHRMLSVMRKLFVFNLVLYLLNYISGCDMMIIILICEHLLMTVTLLRVIWNGVNENKRH
KNLKLQRVINGCVAYCVFSIIALVSFYYGNVVSYSYIYSVGIAIFIVFLINAACIVMYEQ
VQENANVEIYARMAYMDTMTGLGNRTAFLEENKSNAVFPGMISYIMMDANNLKKINDSLG
HNKGDELIITIAKCMRAAVGQNGQCYRIGGDEFVIILKNKTAEETEEIIRQVRAEIEFAD
EQSDIPISVAMGYVWTDAEEKNLQELIHCADEKMYQDKKQIKENTPSA
>A0A8G2A795|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MTNNDTPNMTAQSWQKHYDKKYQYSLRLFLLLTFISAVFSLVSPLYTPVSFTLPCVLIVI
LSAALALWHWKFSQRKINIPFISLIFGVLWASHITEKALLLPAPHFNFLVIALLSILFIG
AIAFPNNITAFTLHSLPTFIACLFLAEGEQWLRMLYCFTLPIAGITLQNIIQKRSDAFTQ
GLMDKLLQERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLAVSDSDHHVLLLDIDHFKAYN
DHYGHMMGDQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTNSTTEAASLAAERIRQQV
YDLKIPHMFNESVATNVTISIGMTPLMDSDIDGALKRADTALYEAKGQGRNIILAS
>A0A1C3JVH2|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MKHNIKALEQRVVAALEDETNQGHPLHEVLEALWQYNQDQWSRMEHLIRVSDSYQDMMIQ
REKTLSERFDKHLRQLDKITRISDRYQTALREANLELEQASYVDALTGLPNRRKMLRRLK
AEFDMRPESVRLAMIDIDYFKRINDEFGHLIGDDVLVSVGNLIELTVGELGHISRWGGEE
FLVIFSQPDQAEVEACLKQLANTIRETHFESGDHAKIRTTISIGVSHYQAGDSADTLITR
ADDALYRAKNRGRNQVVFG
>A0A564WB70|diguanylate cyclase|EC 2.7.7.65|Candidatus Defluviicoccus seviourii|TrEMBL
MRYAHSFEKAVAYAKKAFEQMLARDVPPHPNNFVVWYTYCSGEDQELGKVLDILIDNNQE
FSEERNAAVYNKFCSSPYEAVPMHLIAERMEAELTAAVSVLEKTGRDVSTYGDSLQEVRT
KVREARCAQDVVQLLTGMLTQTRAMASQSREVEGQLRQSWTEVSRLREELEDARREAMTD
ALTGLANRKMFDFMLRDTATAAMEAGLPLSLLFLDIDHFKNFNDTYGHTVGDHVLKLLAT
VLRDTCKGQDTPARYGGEEFAVILPQTTIQQAAALAESIRGRVAAKGIVHRKTGEQLGRV
NVSIGVAGLIYGESMRQFVERADHALYMAKRTGRNKVVVQDGKLDKKSIALAP
>A0A2H6FX08|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MKDEDKTREQLLKELSELRQKIAEHELPGSPRGRTGDALMEKDERFRSLVDSAEDSIYLV
DRDYRYLFMNKKHLSRLGLLGDQFMGMAFGELHSPKETKTFIEKIDRVFKTGGSGQYEYK
SDRDGRFFLQTFSPVKKSDGSISAVTVVSKDISERRISEMALKESEERFRALFNQASDSI
FLLKSTDEGPIIVDTNYAACSMHGYTFEELIGKPISFLEDMETSKEVREVIRRLMAGELV
TYDAEHTREDGSTFPVEVSAQMIRISDRPYILAIDRDISERKRMEEELRALSLTDELTGL
YNRRGLLTFAKQLFKMANRGKKGMFILYADVDNLKGINDSLGHKEGDRALVDVANVLREN
YRESDIIARIGGDEFVVVPVGSTGDSTEKIRDRLKKQLEIFLEKNKREYRLSMSVGLAYY
DPKKPCSIDDLLTEADELMYEQKRLKKKGGQVL
>A0A7W8UF95|diguanylate cyclase|EC 2.7.7.65|Rhizobium giardinii|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTASDGYQALAICDAQPVDLILLDIMMPGID
GFEVCERLKANTRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKNVSDELRLRAETAHSVGLADLTSADRPDEVGKVLLVDGRGSSQERLVRALKPVAEVA
AMSDPQAALFEAAENSFDLVIVNSNFDNYDPLRLCSQLRSLERTRYIPLLLIAEQGHEEM
VVRALDLGVTDYLMRPVDPNELVARSLTQIRRKHCNDRLRTSVKQTIELAVTDGLTGLHN
RRYLDSHLKLLVDRAIARGRPLSICITDIDRFKSVNDTYGHDAGDEVLREFAHRVRSTVR
GADLACRFGGEEFVLVMPDTPADAAAAIAERLRTIVEDRPFSLQNTDTVLSVTASLGIAT
LNPGGDTPEALLKRADTALYQAKNNGRNQVVAAAA
>A0A0F3NCM0|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum str. NCH-1|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLIKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNLLQESF
QETTILSDPTQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSILLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMHFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>A0A808FGH5|diguanylate cyclase|EC 2.7.7.65|Xanthomonas citri pv. phaseoli var. fuscans|TrEMBL
MSMCVVRWRHGLAAFALLLGSGMVSAQPQPWKTIEAATIDDPVVALQIAQGALQRASGDH
DVDAEFWALLAQARVLISLEDRERRQVALTQARGRLDQLHGNASQAQLWLDIVQALSDVR
ENPNRVMVARLEALRQRASALGRNDLLCEVEAIDMWSMLASGSSDESWSAAQASYQCAAR
EKLLGLELDALTQLGALASRVGGRAAEDNETEDYLQRALARLHDQPARFQRSLIEYEFGT
ALATRQPEAGLLHFRRALALSRELRDQAGVAAALTSASEALIETGDAASALTMAREALPL
MQQQGNIGRVAACHAVLLQALIALKAEGLDAEIVAAKAADDPNLTLNRRAQLVDAIAQAL
ASQARHAEAYQELQRANALRAQSLDRQRDTVMLRLQARYEDARRGAETAELRRRSETAQL
ALQAREAGQRTLWIALCAACLLLLGALVVLAFGARHRRQLSRLAMRDELTGLPNRRAIRS
EAQQQIEQALRSHTPGMLALIDLDHFKQINDVYGHATGDAVLKALASASRLALRGQDRLG
RLGGEEFLLVLPGCGEEEIPAVFTRLRSAVAAIDIAGLPPEQPVRFCMGAVRIVADTGLD
VLLSQADLALYAAKTAGRDQWAVC
>A0A8G0CEA6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MPEFLSEFVRFLFATGLMLGGGLWLFSGWQRYAQPKRWIQLLHHAPSGVLLVGEERVLRA
NLAAYLLLGIRLVGRHYLFSAEQSEESQQAFYRALASSAQQKRSVPLLWPVPGNLTQTLE
ISASLLRRWPKKLWLVNVIGFECPSHDIQQERHSLAIARTALDSLSELIFIKSTEGHLMA
TNRAFDQFWQGRIEEGCATFKGIMKGRTSQRCWTVTPDGRSCLLETYQRVLMSPQGENIG
LLGISHDVTDWYNMQRQLREEMEKRRDTEVALAQRDTILQNILESSPDSIGIFNENMVYQ
ACNQPFVEALGIAEVSDLVGKRLQDVIPEHIYARLSDTDSQVLHQGKSLRYIDRIERSDG
EFIWFDVVKSPFRDPASGTNGVLIMARDVSERYLAAEQLEAANQELERLSFLDSLTHVAN
RRRFDEQLHTLWHLHVREGKPLSIILCDVDYFKDYNDAYGHLMGDETLKQLAIAFTQVAN
RHSDCVARYGGEEFGILLPNTPQAGAILVAERIHEKVRGLAIPHDHSKVADKITVSLGIV
TLIPQPEEVPEQMVELADRALYQAKANGRNQTSIYQPNH
>A0A090V0U1|diguanylate cyclase|EC 2.7.7.65|Pseudescherichia vulneris NBRC 102420|TrEMBL
MPPSTAATGSSRLNSMRNYFVPARVVNLCFVIVLVSSTLLTWREVVVLEDAYVASQRNTL
DKVSSALDRQMEIGVNALLFFRNAMRAAVETPLTSDVLKNVQVEFAQQRQQPFWRISVDQ
RRTLPITGVSDDFVAGHPLLSRDDPQMHNEMTAALEVGYIMRLATALPAMPKHAWYVSRA
GFFLSSQPSVASAESVTRYESLLAEPWFTGQSHHANRFRGVRWFTSAHHTDTQASIVTVS
VPLDDAQRWLGVLAIDYAFSSVKTLLEEALRDEEQGEYQLYNSQLERVVTSLPAGVQPRA
FTPAQRQALMQAIAQSNSGSLRLGLSFVVWQKLDRFDGLLLRIHTLREGLQGDFGTISIA
LALLWLLFTAMLLSSWIVIRRMVNNMYAMQHSLQWQAWHDPLTRLLNRGALFERAKALAE
LCQQQHRPFSVIQLDLDHFKNVNDHYGHQAGDLVLTQAARLIGGCIQGEDLAGRVGGEEF
CIVLPGSTLLQAQRIAERIRERISRKEILVHNSQTVRISASLGVSSAEPSESYAFEYLQM
VADRRLYLAKWAGRNRVCAVDPIQDAPNT
>A0A192C877|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAV
YVSRAGFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLKNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A655YLE4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLSATSIYSFGEHFQVAIRGLDSRGSEGDVFFGEPRVFEHAFAQENVYFPYGSWRIAVAE
KQDLLQQLSWYTRNAVRLLGYSVLLVLMAGFGVIMRLYQVAEERALHDPLTHLPNRRYFI
YTIEHYFENAKRSHSEGNFALLNIDIDRFKSINDSHGHSAGDKVLVACAERIKSSLRVSD
LVARIGGDEFLVLIPRIHREQDVLKVSDNILKRISETPIVYDDKLIHVRVSIGYALYDQS
FATPDEMFKLADERMYTAKRRQNPLYRF
>A0A0A6T1R2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sacchari|TrEMBL
MQHSAKRTSGHTRPDRFSSIVMKRPLLVVTLCFVGAMALVTLVGLRQLYTIARSDLQNRQ
RDLEVRAVGVDALIDAERRHLVALRNYAEHVLAAGEQQRIGLESPAVRPALAHTSQPVWQ
VPGLLGGPAVFGTNAAGLADLDGFHRDDAALPGDIALARALSPLVEISHQADAMRGAVAF
VSPNGMFVSAPEHHGMSTPELLRHFSTMYYYRGQLPEHNPRRDVLWTPVYTGLQDGEAVS
TLSAPVYLGNQFRGVVVMDITQSRLLSLRLSTGNIEDNEDPLDFGLLNTNGSVVYFRNGA
VIAQRPARFSPRLLQTAANSVDTWMRQGSGYIERNGQYLLYRRIGQSHWILLAATDNAEL
TIATARRVLGSPLIAAWIVLGLLLIGTLRIVTNIFGHYMEASERLETLARSDPLTGLANR
RRFQEVFAEAHERANRAPQQPASLAVLMLDIDFFKRVNDRFGHAAGDRVLTILADILRAT
LRGVDLPARMGGEEFAALLPDTDLAAVTAVAERVRHAIESHARDATVPASTEHPEAIAFT
VSIGVAASPVDGPIDYEALMHVADARLYLAKQGGRNRVVHASAPMPDVKA
>A0A7Z1D453|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHKCGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A7Z1D3V7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLSKEKRAFTLSWLAALSVLLLLMCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVLTEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSIYRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
NISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A7Z8FBT1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A7Z8BIF6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRSDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7Z8BFW6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGGFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGLPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARIGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A378IU96|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MSDKIDEKELPFKSVLDQTDDVVIITEVEPLNEPFGPKILYVNKAFTTLTGYTQEEVLGK
TPRILQGDKTDKNTLKRIRTALEKKEAIHVELLNYAKDQTEYWLDFTIIPIKDSKGRIQY
FAAIEHDITERKKLEDAKAMLSALVEFSGEAIIGKNLEGIIQSWNKAARNLYGYTEKEAI
DANIKMLFPEEREGEFQEIMDKIVKDEHIKGFETFRTHKDGHIIPVSLTIAPIKNARGKI
IGASTTARDITQQKINEEKLKHLAEHDVLTGLINRPLFEDRMVQALAIAKRTNCNMAVCF
LDIDGFKNINDTYGHNIGDLVLCTAAKCMQKCIRDIDTLARFGGDEFALILSYLNEEKDV
IKIVKKLIHLFSKGFLIENYNLKVTLSIGISLYPRDGMNDLLKKADAAMYYVKKHGKNNF
IFFNAIDKD
>A0A0K2W1S1|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium plurifarium|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTASNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRDFATGDAKPRVLLVDERKSSVERIQKMLRNSAE
LDVATDPNAGFFQAAETPYECVLVSTAFTGFDALRLCSQLRSLDRTRFLPIMLLADEGEE
GRILRGLELGINDYLIRPIDQHELTARLRTQVRRKRYNDQLRASVAQTIEMAVIDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDTYGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGPVAEKVAERIRAEIAQAPFAVGNDGKTIEVTVSVGV
SSLLKGADSVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A6P1Q5D1|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MLPINKGENLSFSLPATLIVALSLLLLAFILIQPDTKRPLLSLTAFIMGSLWAWLIVHKS
ALVFYFDGGFLLISLMTVFFISAISLSEHLLAFCLHIAPPSLAVLTLDRGQHSLTLLFTI
TLPLIGFTLQSLMQRRSDHFTRRLLFQLYEEKQTWSDLSMLDPLTGLYNRRGLKNRLESL
LNSHAGSHFVMLLDIDNFKAYNDNYGHAMGDQALARVSVAIRDAVRSRDVVTRYGGEEFL
VLITNVNAAIAMRLAERIRQHVLDLGIPHHFNHLVSTHVTISAGIAPIIEQDAEQAIANA
DRALYVAKNRGRNTILSWDEICEAPPISQPADLI
>A0A7W7YXK6|diguanylate cyclase|EC 2.7.7.65|Shinella fusca|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAENGYDALSICERTQVDLILLDIMMPGID
GFEVCERLKANPRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKTLTDELRMRAATARAISLEEGLDTNLGDEPGDILLVDGRGSSQERIARALKPIADVT
CMSDPQAALFQAAESNFELVIVNANFEDYDPLRLCSQLRSLERTRFLPILLIAEQGDDDI
IVRALDLGVTDYLMRPIDPNELIARSLTQIRRKRCNDRLRNSVRQTIELAVTDGLTGLHN
RRYLDNHMKLLVDRAAARGRPLSVCITDIDRFKAVNDTYGHDAGDAVLREFASRVRSAVR
GADLACRYGGEEFVLVMPDTPEDMAAGVAERLRMTVEEAPFRIPGTDVFLSITASLGIAS
LVPAGDTPEALLKRADTALYEAKRSGRNRVVAAAA
>A0A1N6M6R5|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MIVNGLEKWLGVGRADSEFRESSFIFISLTVLTLILTFFVCYNVFVIPSRLLAAIEAIGV
LFCLFSYYFLWQSRDPRVAAIILVSVMTSISLLFILGTGNDEFALAFCFLTPVIAIFILG
YKLGSLFSLANFIFVAYICITYMDNWSPVYFDTISFVHLTTIYFFLFSVSYFYDAGRRRT
MVLLEESNRQLQALSNTDGLTNISNRRFMEKLLLDSQVGQWVAIIDIDDFKQVNDVYGHE
VGDKVLVSIANILKVSVQGIGHVGRWGGEEFLVLFTDATEDVIESHIHQCQKSITDYDFG
IGRSVTISCGIAPHLDSFNTSTFSHADEALYRAKTSGKNCFRFSVAHKFTENPI
>A0A6P1PIY2|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MMIFVFGMQAAVVGQNDAWIFMNFQLIALIFCGYFLNVRVRYYYLYPLVFIFMGFNHSLY
YWESWGHAVTLILFFTALGRLRKHVPLQTKQGQVALYLVTCAGFGAVLWWFMKLKFNLSW
ATYWQEWTYLLVFASLLYIYASMLSANAHLKQNLVAFANHDALTKIENFAAYKTAINYQV
TSSRKNGSQLTMLMFDIDHFKQVNDTYGHLAGDKILQHVAQVATIVCRANNPQIALYRTG
GEEFNVIFPNYDLTEALAVAEQLFAAINHIAVPVNDHQIQLSISVGLSELAADDQSPTAF
YQRVDANLYHSKKHGRMQITAK
>A0A4U9Z088|diguanylate cyclase|EC 2.7.7.65|Gordonia terrae|TrEMBL
MALIRRVLRRYDARSMATLISTGGVIPLPVISVLAPETLYPGGMPILLTIWSFIAVVFAV
TAIRARLTDLEFAFLGGLGIVGICGTSMILASPRSSTLVLAIVAVIPAIGAISATTRLIL
SHLALAVVCASVVLGVTTSSVPEYLISFGAMLGLIVVPVFLVVALRKSMEAVLDQQTRLV
GIDPLTGLLNRRGFLIRASQLLSAARSSTGWIGILLLDVDHFKRINDQYGHLAGDGVLLA
ASAAIREHAPVGSEVCRYGGEEFLMFHVVHDADELWLSAERLRAAVAAAAPVTISVGGVC
APLRVAGDHLVSGHFETAFSTDDVIGNLLGQADDCVYQAKENGRDTTVIKSIDEVIWNDG
APSAHAADAERTVSPPSASLYEVFYRRPADFVDIDSRTSGR
>A0A447LUI0|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MNTAHKNSLLGDGAQVLRILTKVIPQLLPHRSVHEIVGDIQLALGSHVTWIAIERDGNVQ
VSQCDDDGKGHEQACQLLRHPRIVNHPYAWRILSWPHSVGAQFYADAPLPLRELQTGILC
KLPLHDYNATAWLFLAYRQTLPSVTLLKHGVTILADKLRDYLLESFAREIAALELQHISE
RYKVLFERAPVLINSFNRNGRCTLWNGECERVFGWTLEEINQASDPLTLFYPDPVVRSEV
RASVNTTPLPTMKEWHPVRRDGTMLTTLWANIVLPDNSVLNIGLDITARKQAEQILTRKA
TIDDLTQCYNRAEILKQLENEFENEPQNSFAVLMIDLDYFKRINDSWGHAAGDKALLHFC
DCIRACHFPEFYAGRLGGEEFLVILRNAGCDDAVAFTDQLRDVLSATPLHIDQQRVDLSF
SAGAVEVKSGALPLSQVLTETDKALYQAKHTGRSRTVCAVIEDPC
>A0A0F3NL07|diguanylate cyclase|EC 2.7.7.65|Candidatus Neoehrlichia lotoris str. RAC413|TrEMBL
MTARILIVDDLIANVKLLQAKLTQEYYDVIVAMSGLEAIEIAEKKHPDLILLDVMMPDID
GYETCKRLKANPSTTYIPIVMITALDNTSENRVNGINAGADDFLTKPINDLALFARIRSL
TRFKVLVDELRLRGKTSTEMNALDDNIMNYANQISNGKILIIDEDKVRTEYINVILQKSF
QETVISHNTDQATNIANTSDYDLIIIDAQFSGDGLRLCSHFRNNNKTRYTPILTLFDESN
DTHLITKAFDIGISDYITTPIDSNELIARVNIQIKRKRYQDALRNHLDNNVAMSIIDPLT
GCYNRRYFDIHFQNIVNESIQKDKSLSLMIIDIDHFKEINDNLGHIVGDELLQQFKQRLE
SNIRVTDLLARFGGEEFVIILPDTNLKSAIEAAERLKNKIAEEPFNISTGSIFKTISIGI
SEISPNDTVKTLINTADQCLYIAKKSGRNKIACLSNNNIVLY
>A0A173SGG3|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MLLGAPLLALLVLLVANLFGTGWIFSISADNAYHRGPLNILLYLLLFGYYAESVWQVHKA
KRDGITVEFFPVYYFVVTCAVGTLLQGAFYGMAFGWLSVAIAFVLVDSQTRSLRGYTDEL
SGLFGRKYMNYCLDRIHDTQEKDVYGIMMDVNCFKEINDTYGHAEGDRAIQEIGHILSGA
LVANSVAIRMSGDEFMVLIRHGSEELLNETCAAIEQRVQHYNETAPAGSFQLSFSTGVAK
YEGGSVEKFLVELDQRMYAQKRAFHAARDGHAAPEQGNAPSI
>A0A653KPG0|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MAQPSRSIDHLLAYSMFPVWAGAIMMLLIVIALAQVPAAQRVEERRMKEHLQRVIKAVQG
DISAINAFTRDWGIWDESYRFLAHPNQAYIRSNLLVDTPMRDFELNVLSYMDLQGAEIWT
RTLLPETPGTDTTLLPFFLDDLKLQLLRESRQEGIRSLSGVRGSQWGPLIYSLQPVTNTL
GNATPNGYLLVTRWLDARYLHDLAERTALSLTLSQPKPSDNFLSFKPLKPQMSYRLVDLG
LQRIRGEGLLLDSNGDPVLTLIVEDDRDVLQGAMEGAIWTFFGMLLISIACVLMALARLR
AIVLGPVSEMVKALQKFGDKQDVSLLPLIDSSQEMALLSRKFREMAAKISLHHSALQAHS
SRMEVAAYTDPLTHASNRRYLDEWLLSRDNVTAARVLVILDLDYFKQVNDRFGHDMGDLV
LCQLAALMRNALGEEEPLIRLGGEEFLLLLTCEEAERVADRIERLRRKIAEYRFGREEVP
LRMTASLGYCSYPLHPELKDSFWNLSFKLADMALYRAKQEGRDRWRGYSGELAREQWALS
PEQIVEGEFLLCQASHLRQPA
>A0A1V5CC62|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin050|TrEMBL
MKDSGLFALDILDVAAAWINREYIHKNANNRYCSAVSRRLDEVVNRSLADIWGIETFDTY
LKTDVDRCLSGHQVRREISLDFPTPGLRLCKILYHPYPDTGGEPTGAVVMIHDLIEPETE
KVNLQTSFEYLTEASREAIILVRDGVIEETGETFGRLFGYAGKDARGKPISDLIAPDHRV
RSMEHIHGQAGGIFKTVGLRHENLRFPMEVNFRRVRLEGRELAIWAVRDLTKFEEIKHQV
EVYQEHLEQMVNAQTQQIEKRESKYRSFYENAIEGMFRVDANGRLVSANTALAKMYGYDR
PEDLIEKAADLGDAYTKPKDGGKVTKLLQDEGVARDLETELYTKDGGRRWARMNVRAEKD
KNGRILYYEGTLEDITEKKWAEDKYRNIFLNATEGIFQITPEGRCFNANPALARIHGFSS
PEELMENATDISTQLHVDVETWYNYLALMEENGYVRNHLWKMYRKDGSIAWLSCNARVVR
DENGQVLYHEGTIQDITDKQLMVDQILMQRDLALRLAQTGAVDAGLALVLETAVKASGME
SGGIWLKGSGEDMKLISSINFSPAFEKKCSFMAVGSRHWKRMMNKSRMVMAPTRESMPNI
YEEGYKCAAVIPILHDGQVIASFNLFSRTKDMISEQVLINLDFLAGQLGSIIVRMGIQQQ
VEQEIKTRREAEKALQAERQGLEEANIALKVLLGQRDKDKEDLEQRFVSNVNELVLPYLE
KLKKGRLEVLQRSTLNLIETNLKEILSPFRVNIRNFNLTPRQMDIVTLIKQGRTTKEIAG
LLNTTKDAIDKQRFIIRKKLGVNKDKTNLRSLLLSLQ
>A0A517X527|diguanylate cyclase|EC 2.7.7.65|Gimesia maris|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKNPDTDIKEVIDTIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITQGPLKSRFDSYWKQSIIQSAAAEL
LAAKSGNDLKYDSFLLGLLQDIGHLAMLRSIPTDLLSVLEQAETEQRESVEVESAELGIN
HAEVGVKMMERWQLSEQFQTAIQHHHDSVAQLKSLESHPDFNLITIIATSAAIGDYFCSV
NSGLALQRLQDLTSEFYNMPHDDLHGFLEQVQVRFEEAAQIFAVNMDDIESPFEIMAKAN
EQLVQMTMKAQVDTTQAFARQAVIEEQKNKLESENKQLQSKAIHDPLTKTYNRSYFNENF
EKELYSCSRDAQPIGIIFSDIDRFKNLNDTYGHQFGDLVLQRVAKVASESTRRSDVFCRY
GGEEFVIMVNNPTENGIRDLAERLRKLIENEVIEFEGARVPVTASLGAVVGIPPRDLTGF
AERLVAEADEAMYESKENGRNQVHIRSIVSKNEQELHKLIKRCRFSRWLVTKEVFDIPTI
SKALLKCSKQQKQSRIGELAIAEKMLSENDVSKILELQELKGLRFGEIAIQQNFLTQEQT
AYLLALQIEPPIVLGKTLISLELLESTQAAELIKQYLAEMKPCSIAADAHRNQLANS
>A0A149VU27|diguanylate cyclase|EC 2.7.7.65|Ferrovum sp. PN-J185|TrEMBL
MLYKSYNHVTISLWIILICILGMLTYYLCTLIYPHFDYVFVFKMLYNSPISLSFITSIFI
TKLILSNKRLKRDLQYDELTHLYSRREIFHKANQEIFRANRNHKPLAIIIIDVDNFKGIN
DSLGHPIGDYVLKNVAADFLKVVRNIDHVGRIGGDEFLIVLPETNFNDAKIVADRIRTVV
SEHSYQIALNQQTKITVSIGITIYKAEENLTKDNVLTIDQLIKKVDQALLFVKQNGKNHT
YCIN
>A0A8H8ZCG9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGMGIAQTKTLAKLANHAAKKWQRQ
>A0A8G0BME9|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MRIATITNWAYSATVCLTIASGVVMLMASSADNTERQVVEQRYQFDQLTEEVELDAWSLS
SLAREYVIAKDPEALNAYRQKEASLKAVEQRLSKLKDIGATDEELALLHEGLQIVDALQD
EQATALASVARGEESQAIALLYGKSYEQELERAQDRIDHFRQLLDSRVRNTIEDATQTSR
TLRTASEVMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVNRLASQDYAVETPSFNQIDE
IGDMAHAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFADVINVAELFAP
NVAPGIAGRLYILDREPWQMRCVAQWLSPQGKADAFHPDECWAVRRGQSHPPVQGEPDIA
CYHLPESCQQHTLCVPLIAQGEAIGLLSFQNLSNDSAPSRAYLELMAEALGLALANQRLR
DALLEKALYDPLTGLRNRHHLEDTLRTQMSQAVRNKEPISCLMIDIDHFKNINDRFGHEA
GDSVIKSIATTIQRVVHDSGMAFRYGGEEFLVLLANTDEQAANRFATDIYNGVRELSLRF
GLSEIGHVDVSIGVASYPQHAQSDNLLRAADVALYRAKELGRSRIVSFGMLEAS
>A0A0D8I7I7|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MDPLLQSWPVPPSVMLWGSKNGPGSMLRLVNFTIGFCSLNFSLVAYLFLISGEGPDRQFA
RTWLIAFATVNLIPTALWFLGKVRGSRALKLFGIWADLGTASVIITFTSHDAALFGAVLF
VASGAYFTYFLNFRWLAFHLAFSCTFIISLAILAITRGTLPTAGVIARTDVILCAVIFIP
ATIQLAWRQLLARANGSKVDALTGLLNRRGLWDMAERVWSTSHANRVDVAVAVVDIDKFK
AVNDAYGHEVGDTVIIRTGNRLQQHVNGFGYAARTGGEEFTLVMIGTPYGLRKRIATLPR
AVVEATDAPLATVSIGASTMPFTPDVEQFDYTAFSRAIVHADHLMYEAKSSGGNSANTAP
LDMTRFDRSGN
>A0A6J5E9S9|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia humisilvae|TrEMBL
MKPRIVRRHTGPHRDVTRRPSLEHVLRSTYARLAFAAVSLAAVCVVLVAWTVLRTYANDN
LMLLARSIAYTVEAAVVFNDKTAAEDAIAQIAGHEDLAEVRITDTHGATFAIWQRTGDGP
LTRWVHRLADLPLPGGAVVPVTHNGEVVGKIRVRGRGHQFAIFLAGGIGAVLVCLIIILG
AGTLIARQMHRNIVEPLRALAEVAHAVRRDRAFSRRVQATPIAELHELGDDFNALLDEFE
VWQHSLNEQNATLAHQANHDRLTGLPNRAHFESRLEAIIREARVSGTTVGLLYIDSDRFK
EINDTLGHDAGDAVLVAIASRLREALRKTDLFARLGGDEFVALLQGLTDEEEAIAIAEAL
SESMLEPITLPGGHEVTTSVSIGIAMFPLHAHDVASLLRTADSAMYQAKRHGDRAWQLAK
>A0A0D8HY01|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MNPIREVVERWLAMPDQFDRFTRLLRGNGFLEATRILIGLMVFSMGVTVVGKRLGTASDQ
VSSIPLDLMIGVLALIGGLAYPVFTTTRNRSLQFVIASDVSIAIIVLTEADLDQRLLGSL
VFGLMGTYIAFFHNMRAHLVHLLFSITIVVAACCGVFTEEPTTFFDTFGRILFAVSVISV
VPFLTQIALILLSNDAQGSELDPLTDLLNRRGLARRTAELIRSKSGIGQSLLVVVIDIDN
FKQFNDTFGHDVGDRVIIRTANRLTAWARADAAIARVGGDEFIVVQIMPLSDVGDLISRI
HPAMNTPIVEPRSTTSIGIAIHNGSWLDSDAEEAGIDALHRLADSAMYESKRLGGNHVHT
IVMTSP
>A0A1H8MT88|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MKQSGNAKPLYRESAHSAEERGALFDYAFEAAPIGVALVSPSGKIIKVNGSLATMLARAR
DDLTDVPFGHITHPDDLETDLNLFDDVLGGKRDGYRLDKRYLRPDNSVVEACLTVTAMRK
PSGEVARLLAMIEDVTEARWIERQLLERATQLELAMEAVRGGFWHMDLQTKRFETSDRLA
RFIGGPHAGRMELNAYLANVHPDDHPAADLTPLLEGEVDKSVAEYRLRTTEGERWMRCDR
RLLRDAQGTPFRIIGVVIDFTEEHLRRAELEVNADTDVLTGLFNRRGLQKKFDRMSKEKR
RLVLTIDLDGFKEINDSLGHAAGDQVLIETASRLKAAVRPSDAVCRLGGDEFVVLLEGGG
DVAERVASRIVAELAAPVDLKDGVVLVEASVGAAWTTSSTPTLEKMMRHADGCLYEAKAR
GKNTAVVCEIEMME
>A0A0J8SUT8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. VT 511|TrEMBL
MDNECMHMLAGQWQHICQNYSSDDLVHAFQFIQDNAPILVEEFYKNMLVEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDEAKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYS
QGGDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGMQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A2Z5SJS1|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MTIPAIEMFVGETAEIVSLGDDFPDVKKLKNMGVREGKLIDLLQSDPLAARKVVLGVDNF
RIAVHTELAAQMRVRPIKSYYEAVKVQAHYDNLTGCFNRHALEGIVRGEVLKYAEKRVPF
SLLLADIDHFKKINDTYGHQEGDRVLKRFADLLRHGLRRSDVLCRWGGEEFLILLRGTLV
EEASLIAERLRRIIEESIFPPFAAEGLVTVSMGGVGMPPGTDVNRLFADADSALYISKRA
GRNRVTVCR
>A0A4R8RHX3|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MQPPPHAETGFQYELVTNALRDTGQLDRLKNAIGLLCFLIVILEVITQFYPLGPHGTWPR
VIHGTVAVSVVMVGLCWINFSWPSRRAMIAFVVWADVALAIGAALLSDPTARICAVVYLG
PVGLLPTFFLGRRALVVHCVFATSLLGVLVAVNVLSGEARLPEQFFYAAPVISAIVLVPA
IIQAVLEGGQDSILSAALAADRDPLTGLLNRRGVTTAVDLLHRGRIDAVDIVVVMMDVDG
LKELNDTHGHGAGDVILKQVAAMLTASTRVGEIAARIGGDEFLVVAFPGRAENIDSTIRR
VSTPRAGIDMWSVSVGAAWQSQTGGKVDLDLLVRQADYELYKVKSSRGMLDPQH
>A0A1C3JH15|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MNHFVFVTFLLFISFCSYSQVSTSDRDHNSPVYTSNLSTTPNADWNALYLSTLNHSPERA
LNMLQTRYIGSTVYGDKLYLASLLYQYMSHRDQPFYGIASNDSDYQAMETAFISALMKDG
KGQYEQAQQGFLTLLARMQSRGDLTGKALLKYQLCRSLNEQAKYHQANYYCSALESDLHD
IADPVLPKFGTYRVIANNHHFRSDYQAALDTYLSLINVFPQGHDISGVYNDVGNLLKELK
QYEKSAEYLEQALILRVNASDLMKAQVHHSLADLYLNQEQSELAIHHFQTARTLLSSTSH
SYGIALTSLGLGKAYTQTKNYDMARTYLIESLSASSELSNDVIRINTYLAISDMFEEQKL
PTEALNYAQQALEIAEQVTRHKYIAQSLLQLSDIHQSLGDYQQAFYFYQRYSSIQMEARD
IDNRLALEALGLTHAKYEQELESSFLTHQTKLDRVQIEKMEHQRWMYNIVIVLLLCAASF
TVLINKTVRAKAAIDGLTKAYSRTEIIRRIKRVKRCKGSDKQHVLVLLDLDKFKKINDQH
GHPTGDRALVHISDQIRKHLVNGELFGRLGGEEFVIMLTDTQPAEVRERVEELHYAISST
VFLSESKKSLNVTASFAYLATSNALSDFDDLYSVLDQALYQAKSNGRNCIIDAYNEPIDL
PEIIYSQPVCEPTQP
>A0A1V4VLU2|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MRPKGFVHILYIWLVVGLAAWQLYLLIPALDMDRLRELLSIVLLGVLAEWLAVSFPHGQL
SGSFALVLSTYLIFGPAATAWVSGLSTLFGQGIANRGNPARTTVFNAGQYVLAAVAAGHI
YQLCGGRPGWSGFAAIFPLAAFTVSYLIINHLLIYFYLLPKRRHYPGPAWLDAVKWDSLT
YLLTVPLGLLIAMIYVYTGITGIMLLFSSVLAIQLIMRHYIHLHVANRELKAFYDVATFL
EKNPDLGELLNFILRSARKVFPYHSGVAYLRSGERDAFAPVAATGPYSKELKRTIVYRGE
GIAGCSILDRKPEIISNCRLDPRTRNEAGLCQVMRSLLIIPLLSGEDDLGVIVLGDQRPM
AFDEKHLHIMAVLGGQAALTVEKSVLASRLEHAASLDVLTGLLNSGVFFQAASEICEAAV
ENGALLGLMLIDTDRFKNFNDRYGRAAGDDMLAELAGIVKGVTRGDDLAAHYGGDEFAVI
LPGAGGRRLLDIADSLSNEIREHYFLRRAGRQARITVSIGVAELPRDAGDAAGLFKAAQR
ALDKAKKEGGNKVVSAAASIIGLS
>A0A1C3JIK6|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MIDRKYTNLVIIEQAPLYTEGKVVGQGWNGMLILREGDKPVGWIAMDNYIHRSPITNYQK
QMLESFGSLLSQIYIRKRQEQNIRMLHSSMVELSRCDSVSEVCKSAVSFAIQHLGIDRLA
VFLTDKGCNYMQGTWGTDIKGDIVDESYYRSELVERDIVAAARACPNQVAFEESVPIYHD
FNIVGVGWTAMTMLTTNTGEPIAFIAADNLLTRSPLTSQLREVIRIFASSLAEVLQRTMA
QEELKKLNETLEQEVSKRTQELERVNEQLDIISKLDPLTRLGNRRMLSQVLEDLNCDDQG
AFATQHEVTFGLILVDLDHFGLYNSVYGHTEGDAALRSIGKILNNHVYSEQETFCRIGGE
EFMLLMIGTNHSETKRRAESIRKCIEEAKILHCESSTSKYLTASVGYASITSDQHQFDFD
LLYGKADKALYQAKDSGRNRIVSALKRKKVAVSIS
>A0A0J6VQR8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MSYEVADDALRLRQLIDRLPSMVAYWDANLCNVIANNAHAQFFARTPAEIRGRHIFELLV
GDLGETSRPYVEAAMNGRDQVFEKTLTDGNGLTRHVQASYLPDLVDGAVQGLYVEVADVT
ARVEAERARDEAQRLLHISRENAPFGEAMFTTTGDALYANPSLCRMFGLPRGEDAVALNY
LDGIHPDDRDAAEQEWRQLVERSAPQIFAEFRYVRRDGATIWVQCHAVLVAAAHGGADVV
LSQYQDVTDRKLVDAEFARLAVTDQLTGLHNRHSLVARIAECREAQPHSPVGVVFADLDG
FKRINDTHGHAAGDAVLQAAARRLADAVAPHSAYRLGGDEFVVLMIDSVTDDLVAQLASL
VAASLSGSHQLDSGEVSVTASVGWTCNVPSDITELIRAADLDMYRHKAKRRTLPDEL
>A0A128EUD2|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MSDYTFFEATRIFKRAIPLMVKYKVPTTPHYFSLWYTYCAGTYPQLNKAIENKISRFGAC
SIRHCDEIIDNYLIDDAKREVNNFRQKLEALTTNLGESMEHTVSDTEEFRDILSNSVDKL
ENVKGDIAKNGESKKVLHELLKGSQHLLSATSQYQLQVTSQKTEIDALKKQLQEYQKQAS
HDALTGCLNRREFEKQLDKNVNQDNVFSVMMVDIDHFKSFNDEFGHQMGDKVLQIVAAKL
KQVVDTSGAVFRYGGEEFVAILPGLPLKSAFIYAEKMRLTLERLSVTDKRSGQKINSITA
SFGIAEHKKNEFGHALVARADEALYSAKHKGRNCVMPQVR
>A0A6J7ZL33|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MEKIKVGILYSLSGTMAISATPLLEATLMAIAEINAQGGILGHQIEPVIEDGASDISIFE
KKARKLLEIDQVATVFGCWTSTARKAVKPIFEQFNILLWYPVQYEGLESSPNIFYTGSCL
NQQIQPVISWSLENLGKRFYLLGSDYVFPRTANKLVKSLLKHEGGTVVGEQYFPCGDKNF
TDIIEEIKHLKPDIIFNTLNGDSNFYFYNAYYDAGIKPSDLPIMAMSISESEVQSIGQAS
IGHYACWSYFQSLNTPHNHEFVNNFKALYGQERVTSDPIEAAYFQVYLWKKSVETAKSFK
TNEVRKAAYCQTFYAPGGLVKIEPNHHLWKHCYIGRVNEIKQFEIIWKSPNLIKPLPWLG
VEELKNFPQADLVIDMLAEVSQGIQYSCLLEQNSLNLELTMQKLQLEIEQRQRIEIALQE
VNKELKYMAITDSLTKLSNRYWFNECLKSLWHKNLHSQTSLALILCDIDYFKNYNDTYGH
QMGDYCLQQVAQAIKKAVRNSCDIVARYGGEEFAVILPHTTLFDASQVATRINQEVQELQ
IPHLNSLVNDYVTVGYSSIVFLDNCCIF
>A0A6J7ZSF7|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MSLSPSVEENQRLKALYHYNILDTASEAAFDRITLLASRLLGVPISLVSLVEQDRIWFKS
RLGLDCPEVDREGSFCGFAMYNQGVYCINDTLIDPQWCDHPLVAGEFGLRFYAAAPLCTS
DGQRLGTLCVMDHQPHELSELEVQTLQSLGELVIEQLDLRLASQRLQQTEIALIQSETRF
RALVEQAADGFLLHDFNGRILDVNEFACQSLGYTRKELLSLSLEQIEVDPLPLVFFQSLV
QGQPITLQRIYRRQDQTTFPVEVRLGLIQVGGQQLIHTLARDISDRLEIEQQLKQQAERE
QLNTRLTQRIHESLELSQIINTTVTEVRQALQNERVIIFRFDSDKEGEVLTESCAQGCFS
MLGNRYKDCCIKETLSLEKIDQVKSVADIYTSNLSRCHQKLLIKLQIRAYLVTPIWHGQK
MWGLLVAHQCSSPRKWQAWEQELLFSLAAQLAIAIQQSELYHQLQIVNHELKYLATSDSL
TGIANRRYFDEYLQSQWDQLSQEQAPLSVIICDLDFFKPYNDTYGHLAGDQALREVAQAI
CKAMRYPTDLVARYGGEEFAIILPKTGIDEAILIAQNIQTQIKKLKIIHSGSSVGYYMTC
SLGIGMVIPSKKINYKQLIEIADQGLYQAKAQGRNQYVVSSLSHSMSLN
>A0A0J6W157|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MNHIRGWWQQPDRYDWLARYLAKRQLLRISSAVMATIMAVLAVALALTTMSPAGPEGSAR
PVVWVIAAGFVGVAAAYARRWPTRRQSAVFSICGCAALAVVAVLQSDPHAGLLTCWAFVG
LAAYVASAHSPRLLVLTVTIALGTAAACAVRMGVDGDVPLGVATLLMSIGGLLTVPFGGH
ILTRLLWNDAVSTDPLTGLTNRRGFRRSAHALITEAAQRGSGSFSVVMIDLDGFKRLNDT
LGHAVGDRVLVDVAGRLRAACGSGMISARVGGEEFVVAQACPPREMEMVARRLCAAIAAN
PWHVTASLGVAGVAVQDLAAGTRTLIDRAIAAADMAMYEAKRAGGNQIRQSDAA
>A0A4P7TMS7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTSVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLGANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A149S7W7|diguanylate cyclase|EC 2.7.7.65|Gluconobacter japonicus|TrEMBL
MTTDAREVQEPSAAQKEWQNLIAQTSDRVRNIVAEVIDRHAMDCVQRFYDVLLNNADAAL
FLSNEIVDTRLRAALGRWLAELFSHDAPDAGALVQTQQRIGAAHARIQIPIHVVMHGARL
LKRKLRMFIQGLELAGTEYSMAIAYVEDMIDIAIEVMSLAFVQGTRKEVEVNEAFRLMSL
GKDVSLERETQRAALLEWGQSFLLDICYGGGSASTLSDSAFGLWLRHKGSVLFQGASEID
VVLKAVEHVDNDFVPRLVSERPVSPQAVKALQRALDEIHYMMDQLFKAAEAVENGRDPLT
KTLSRRFLPTILGREVSLSLRRHIPFSILMVDIDHFKSINDTFGHVVGDSVLRYVAKILV
AQCRMSDFIFRYGGEEFLVLLTETAEEQAIQIAERIREAIERDSVLVVNGNNIHTTASFG
IATFDGHPDYRHLIEDADRALYLAKSSGRNQYQVRKRHDSVFQTGEGEEND
>A0A378L8I2|diguanylate cyclase|EC 2.7.7.65|Legionella steigerwaltii|TrEMBL
MIFKLGKEAIVLLIEGSKKAIPFNIILASLLALIIYPHVPFYLVSIWYCGILLISLIRWL
FCRHIIKNKLYEVKKQYILITFFLLTLVIGIAWGSCYLISLPYVTELYEFIIILVLGGMS
AGSIASLSAYLPAYYAYIFPMFLPVIIYNYSVLDIDRTILATMFSLFIVMLIVSARINKN
LLDRTFQLSQDRESLIFELQLISITDPLTGLYNRRHFEVLFPQELERAKRNRYPLNLIFM
DVDNFKLINDNFGHLYGDKFLIGIGELLNGVCQRANDTIFRLGGDEFAAILANQPLGEAL
SICRTISNQFRENLLHGDFNMNEQTILEQVTLSMGLVNIHFESSSNIETVISLADKALYQ
AKKGGKNQIIIEQLH
>A0A0J6YVZ6|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MEKGLRDFLLIWWRQPFDFAWTARHLRSRGMLRIHQVFIGAFSLLYGLTALLTMLWASRD
GGAVTGQALVLVVAISSAVLGLIWIVGPFPTKRQSAAFAVYADFAVLAVIACYQDAFTAM
PGLALLAANGIYIVVAHGPRALALHLVFTVAAFGWLYALALAQDTAEPSVVTVRLLVLLP
TVVGVPVIVQSYLLALRMGAVDALYDPLTRLLNRRGLDDEVTGLVPAGGAHLGVLAVDID
KFKAVNDGHGHDAGDRVLVSVANAARDAVTSLRVRSVIARTGGEEFVLVVDAGPRTVREV
ADRLHQAVTRCDATVVPTVSVGVATAWTSDRELPAAIRALIERADAAMYRAKGVGGNCTF
SADDAVPAGE
>A0A5H9WVM2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ajiobo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A238DRQ8|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MAFALYRGPCGAPRLPHEAARDIARPAKVSDTRQPRTESAPNLETLPPVLAQAIDPDGSQ
TERTDLLRVRSLFALGYAICMMLTLVLFGVYAILHWQAQQRSLNTRLASNAQLLASATQG
RLGQYTVLADALAASLRRNPQLLANPAELEHRLMQARTGMAGTAILRVVDAQGVILGATA
ALGPAFELRNTPQIWAGLLQARSLGRPVVGPLVRVPALGMWILPQVHFYPAKGQTPAFWI
GVGIDREAFNRFWGGLMSRQMGSNRLRQSEAFILVRQDGYVLARWPDVPAAQFTVYYTRP
QTGILVRSLQANEGLSGTAFHGVVHSINQERRGYWTRLGPGAPDLAVSVSLPASVLWSDY
WRSLAPTAAAALLILATLTLAYVLLQQRMRTEARAINARHEALLSYNGQLRQLADKDYLT
ALPNRRYLMAQLGRLCDAGEREEALRFAVAILDMDDFKRVNDTRGHTEGDKFLKVLSRRL
QQALREGDVIVRLGGDEFAILLQGLTQGRDAMQACQRLVDCARTLVELNPQDAVQVTASL
GLALYPEDGTEPEALLRHADQAMYAAKLSGKNLVQRFAPRMEEAVHAQQSAFDLLRQALT
EHWLCLHYQPVVGISGREVGRVIGVEALLRIRHPEHGVLAAQSFISALDAPHLARPVGRW
VLQQALGQAQFWNAQGLDLRVMVNISTLHFLDSAWLDDLREALAGHPGVRPGQIEIELTE
SGALRDLDLAAQVMRASVAAGVRVALDDFGQGETTLRYLQRLPTHAIKIDQAFVRDMIDD
PRDYAIVAGLLHIATLMGLFTVAEVWKISTP
>A0A1V5UST5|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin236|TrEMBL
MNSWAVYFIPLLAVSAVYRFSADQSLAVSVALAAGIVAFASFNRQGTLYQAFMWAAIVMA
VWAVSVQRFRVSQEEKYRMMYLDQEKAASELEKKIRELEEKLQSHTITDTVTGLKNFRYF
RARLEEEVARAQRKNQVFSLALMEIEDMPDFSKVYGEQETRKALARLAAKLKDAFRNTDL
LCRYSDTQFMMLLTEADAKNSLVPIMRMRKNLEKTSFGPDNRFQFSYSFGISCYPYDARE
AGGLLSLASASLRRSRQKGSGMITLASSLFKKGPVS
>A0A7Z7RG11|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MSGPLSRYRLAIIVALLLLAGIIVNAGLYYQQGSQDIRHGIVEQGLPLTGDTIFSEIDKS
ILRPLSVASLMANDTFLQDWLKDGERGPDRVARYLAAINGRYGITGSFLVSESSRRYYYA
GGVLKTVSPSDPEDRWYFRSLKNAQGAYDIALDEDMTNGGKTTLFINHRIVDSQGKLLGV
IGVGLPQAELSAQLAAHERRFQRRIYFIDHDGRIVLDSAGAGQRKLRDLPGLAQLADAIL
AGGPEPRKLEYSRDGNRYLLTTRLLPELGWHLLVEQNETRALQPLHAALQVNLAINSTIL
LLVLIAVLATLQHHQRRMRQLATTDPLTGCLNRLAFLDLLPGWLRACERASAEPQLLMID
IDHFKQVNDKHGHQIGDRVLREIADLLRSQLRGGDLLIRWGGEEFVVLVHSHGDDDALAE
RLRSIVANHIMSASGKRLTVTISIGLCQWLPPETLEAAVARADLALYAAKQGGRNRVCHA
QPYHPLDEPVA
>A0A7T4Y5Q4|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. ISTL7|TrEMBL
MTSDPEPTLPALPRWQRVSLASALFFLLAVAGIALTRYPGNAAIVWLATAFGAGVTLHQP
PRERAWMLAGMLVAGIAANAMFGDPWWLALVLGASNIAEILFVAWLAPSISGGIGRASAV
PLARFALMLGATCTLAPVIGATIGAAAISIAYGQPFAGIWSTWWSADAMGMLMLVPLSVT
YSRERLRDTFPRTRLPRVAGLLLLTATVGGLAVVQTHDPFGVLSLPLVVAALFTNPFATA
LLTLLSMLVTVMLGLAAAQAGLVDAPQFLTHAMKLSTSLILVFPVCIAYLSEQNRRDRSE
LRGSERRFRQAMHHSAIGMALVSVDGRWQQVNRAICELFGYSATELSRIPFQQITHPDDL
AADLAQLERLVAGDIDSYRMEKRYRRKDGNFIWTLLAVSLVRDEASGAPLHFIAQVEDIH
EHKLAQQRLEALSRRTELAVEAGRVGIWEWDIAAGTLSWDRRMHALHGTAAADGAPDLDG
WIALVHPDDVARARHEMRQAVKGAQPFDTEYRILRPDGQVRHIRAMAVVSRADDGTALSM
VGTNWDITEHRRLTEALFEEKERLHITLRSIGDAVICTDASLRITFINPIAEQLTGWTMA
EADGRPLATVFHVVDETGGQPIACPVAKCLQTLRPVYLEDGAVLISRHGERHDVQDSAAP
VLTPRGDVIGAVLVFQDITAARALQRKLAHSAMHDALTGLPNRIWFEQRLREACESAREF
DQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRSQVRPDDLLARLGGDEFALLLR
NCSVDQGERVCLKVIDAIRARRFPWEGRVYDVGASVGITAIDREAPPLGELMSRADVACY
AAKAAGRNRVSVYRRDESDARRHHRELQVAAGIHSALEANRFRLFAQEIRALAPGSGSTP
PAALPASSPASPPASHIEILVRMVDEHGSLVMPGAFIPAAERYDLMGHVDRWVIQHVLRD
FGARLLAVPGLSVSINLSANSLGEPFLLPFLHAELSNSVLPASRIRLEITETALINNMAA
ANRLVAEMRKAGCTMALDDFGAGLSSFAYLKQFPVDYLKIDGSFIRHLASSAVDREIVSS
INDIGHRLGVHTVAESVEDEATLDVLREIGVDYAQGYAIGRPMPLEDYLARCATGTPGET
AQRQPR
>A0A378RBP8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MAETELDAQLETLVRRAGRTALAVVFVVTAADWLGWATGTERLTRVFRSWPQMTPWGALV
MATLGVAILLQSGRATPGRVWVARALAMACAAIATVFIAEYATGLAFGVDRLWFPGGVAA
MQRPYPGRPAVQTAVTVLLLGIAVALMRLDHRAVRSVRTVCLVSAAIMPFLVTVVYTFHA
LSVIETTPSTGMGIATAVSLLLLIAATFAGRVDANPVAWLLARPDGLGLVRMAALFVALP
LVVGLSRLAFLAFGVEEGAVWPLSISAGAAVIGVAVFYLSQREQRLLIDRALLIREREDA
EARYRILAENAVDAVIHLRGTQVVWASPSVRTTFGDRSWIGSDFDRHIHADDVGLVSVGR
QPTGAAEPAVERFRIMRADGGHHWVDCRSKPYVGGDGETDGVIAALRVVDDQVEFERRLE
RLARFDELTGLVNRAEAIARLESALAALASDGGCLGVLFCDVDGFKRINDQWGHAVGDTV
LAALATRIRDCVRQGDTVGRTGGDEILVLLPAVRDLDAVIEIAESIRHRAAEPIYHPGGI
IHASLSIGATLAVPGETATTATARADEAMYRAKETGRNTVVQVLGA
>A0A1R4HCJ9|diguanylate cyclase|EC 2.7.7.65|Crenothrix polyspora|TrEMBL
MVKVTGQTIFLKNAWQYALAGLLFYATGWLAMMIAPPPAYISSIWPPAGIGLAAVLLWGY
RVIPFIFLANILLYLKVFDLASVLDSPQKLMALCSVASCGVLRVWLATILIKRFAQFPYT
LIAIRKIALFFTLTGGVAAFIPTALTVFALHISGVIVTQDIYYAFIKAWIADCTGVIVFV
PLFFIIFDRQQRIWEERIITLGLPLVICFLATIALALFFQQQATQYLQFQGVFLPGFVSI
VLLILTGRHEWIKIQVEQRTEQLVKKNHKLSKRDKQFKKLLQTQSVIIWRADPVSYRFLY
VNEEAESILGYPVTQWRDESDFWWQRLHDDDKDRVQAFCAEEQAAGNVDLEYRMISAEGT
IVWFRDSHTKVIKDGVVSELYGLMLDITKQKLAEEEFRVAAITFESQQGILITDRLGKII
RVNKAFTEITGFLPREVIGKDPKILKSGRHDKSFYKHFWQELADVGKFEGEVWNRRKNGE
IYPEWQIVTAVENNREVTHYVSVFSDITHKKEAEDKIHNLAFYDALTGLPNRRLLLDRFE
QEIAIARRHKQFGAVIFLDLDHFKLLNDSQGHLVGDELLIQVANRLSSVLREEDTPARLG
GDEFVVLLHANSENLIEVSDHARTVAEKIRKQLNTPFLLHHYQHQISTSIGITLFPEGDE
RPDMILQQADTAMYRSKSGGRNAISFFQPFMQEAADQRLKIEQDLRMAIEKEGFMLFYQP
QVDHTGVMIGAEVLIRWDHPEQGIVSPADFILVAEESSLILDIGLWVLKNTCQQIRTWLA
MGITVPRLSFNVSSRQFRQREFVDQIKNAISETQIPPHLLGIELTESVMIIDIADTVAKM
KALKSLGVSIAVDDFGTGYSSLAYLKSLPLDVLKIDRSFVGDILLDSNDAIIIETIISMA
RHLRLRVVAEGVETEEQFELLKKLGCLLFQGYYFSRPLPSVNFAQKYLRSAKSE
>A0A1J5RZD3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFETLRTLLHSLRFRLAIASSAVLMVVLLLVAGNGVRLLDRTLTAQQDRQLTRMQGLFNA
TLAEPLEHRDLSALTALLGRLRQDGGIDYLVLQDAEGAVVASVGRDPASPLPPQRASYAQ
LPAGAKRFDGVCTIHLGSLVLGRLFYGIPVGYAHAAKSQLLFQSTLIGWSSLILSAIALI
AIGRWLTRDLRRLQRGVAALQRGEAAVKLTVSGSGEIAELTRAFNQMAAALDERVRALQK
SEARFHAIADYTFGAEAWLDPKGHLIWVNRSVERVTGYTPQECLAAKNMVELLVYEKDRG
HLLSQGWQALRGGQGQNFETRLQRKDGAVIWVALNWQAIYDAQGGYLGVRVSMNEIQARK
EVELRLLETVAELRRAQGLSGAYLRRSNEERARLAALLDVLHIGVLFVDTDHRVIYCNDP
YRSIWGFAHDENLVGTRETVLLGRSASLRLDNAAFLLHLEQVEASTVTSAPFEITLVDGR
VITEISTLVRGAEAGRHIGRVWTFEDVTERKETAEQLTQLATRDPLTNLYNRRRFHEELE
RMLPDAARRGGQVGLLAIDLDGFKPVNDRFGHQAGDEVLVTLAQEVSATIRRNEMFFRLG
GDEFAVLASDSTEEDMVGLAKRVGSRIAETRFVFAGQETRLTASLGIALYPAHAGTAELL
VAYADQAMYQAKSSGKHGWQVYRKEVRH
>A0A1J5QWI6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDSASSLPDPDILMEIIRSQTEIAQQGLDLGGVMAFVSERLQGLTGADGAVVELAEGDEM
VYRAASGIARSQLGLRLSREGSLSGQCVARQRILRCDDAETDAQVDREACRKMGLRSMVV
APLKHGEATVGVLKLASARPNAFSDVHLRILELMSGLIAAAMYHAVRFETDALYHRATHD
ALTGLANRALFYDRLRQTLSQAHRQSSFLGVLNLDMDGLKPINDTHGHRAGDEALREAGR
RISSISRQSDTVARLGGDEFAVILTDVGGRDNALRHADRLAEEIRRPFSFEDKALALDAS
IGLAVFPEDGTDMDSLIEKADQAMYAVKRARKRLAESGAAVAS
>A0A0M6XWY9|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MTLDTPTLFTCIMIAEFAGSVILFLFYMFWPGRSVACSRSLALWSAGMFLAACGTVLLAF
RGTIPDLFSIVAANFLVILGTGLRRSGFAVFLGRSGHVWVFATIAFAWLVLCQFPEFQDN
FLTRVNYVQSVLILSGLWVVWMAFFENREKLYSARMLGMTTLVETAGFMWFTFHQNILLF
PSFQSTFTEGFMSTYLITVLFSIIMTIVLPASMVIERSLHGFREQALQDDLTALPNRRAF
LNDAEDWIASNSSPKGIYSLILFDMDQFKSVNERFGQAMGDALLQLFARILKDTLVENAI
SGRIGGAGFAVFLPEGNKELAHLTAQRICRRFGLECQEASGGRLMVTASVGLVSASVSTP
LERAMEAAEGGLHRAKKQGRAQIVTMDLAPNGRLIKDAKRTGFSVLRKKAA
>A0A1Y2MYY7|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia autotrophica|TrEMBL
MTRARRSAYRCPTLDLPRPMVLVLFTVELLTVGLVAGGLAALPADRSTGLALLGAIGLVA
LGVVHTELATGIERVRRRVAHASYFDLSSVWTFAGALLFPPGVAGLVVIGVYSHLWWRVW
RPAGAGFYRHVYTTSTVVLAAIAASTVVAPDGLATVAGAGGPGSMLPAVGLLLLAMAVYV
VVNQVLVALALALTTGRRFALRGVLGEWDDHILEGATLCLGVLAALAALRQPLLILLVLP
PLLVLHRAVLIRQLEERANTDAKTGLLTAAAWRGQAHRGLARGRRHRDAVAVLILDLDHF
KSVNDCYGHLAGDEVLTAVARTLTAQVREVDPVGRFGGEEFVVLLAGLPHGQEGRTLAHA
AAERIRRAVRGLAVRVDQPGGPLTIADLSVSVGVAITGQDGESLEELMQVADYALYAAKR
AGRNRVRLGRSEGEPGSEA
>A0A1J5R5P8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPAVDSKIAHQDFNEARKLGERAFELLLEHSIAPTPQHYAVAYLYAAGTHAELRAEIDQR
LQSGRALDAFLLAELHERHIAVDPYKNLRGVGGDLKQLVEQLANSVGEAGEGAAAFGREL
EASLNHLDGATAADAVEAVVVRLADATRDVVRSNERLQQQLHDTLEETETLRSELEQQRR
AALLDPLTGLLNRRGMDAQFDELMAIDSGEPLSVLMVDIDHFKRINDTYGHALGDAVIRN
VAEVIRKCLRGADHAVRYGGEEFIVLLPRTPEDAALHLAETIRTRIQSLRLVRKRDNFML
EPFTASLGVATRARDDTRETLLQRVDSALYASKGAGRNRVTVGAAQFVSH
>A0A1R4H8Q6|diguanylate cyclase|EC 2.7.7.65|Crenothrix polyspora|TrEMBL
MPAKIAFILFALWFGSPVQSSPVQSIALNQITDQFLGKHVWVLKDSEQNLAFFEVYRHHA
KLPWKSSQNDVPSLGFTSMPHWFYLAIHNDSPLAQQRLLEINFPTLDDIQVCYLARKLDL
ASVICLTEGDRYDFSKRPIIAPQPVFPIQFAPSSTTGIYIRVKTSTALELPLRLWTDKAF
NGHLQTQTLVLGLLFGIALGVCAYSLFLYYCTRETLYLYYIAALISSMLMCSVLFGLPYQ
YLWPEHSEWNERFTKIFAGIMPALITLFTKRYLILFFELNARSPKLTKLLDIQILSSGIL
AILGMFLIYSSEFTLWCRINFLWIEVSILYIGIYLVFKGANYAWFFLCSAACVAVPGIIA
TLHRLAVIPYLPTDHIVLASITAMFILLSLSITKHINKDREEKLHFQQKSIIHLKRYQDL
YDTAMEGLFCVHPNGQLVYGNPVLEKTLNISLKTLSSHPVFLHNYFEPTQNIWKNLTAAL
YDQGSLINHEVQGKRKGDNSSWYMISARFTQTHEGEFIEGSLIDISQRKHQELQLAYLAH
HDPLTHLYNRTAFENYLQDAVRSQSPHTLLFIDLDQFKVINDTCGHAAGDECLRQIAAIL
QEHTDPQDMLARLGGDEFGIVFWDQNQLDGKASAKRLLQALAANHFQWLQRVFKTSASIG
LITIDEHISCGEQALSLADAACYEAKEAGRNRVVANHPDKQATIYRHSQMDMVATLTEAL
RNHQLVLFQQPIIALFTEPTSLQHYEVLMRLHTDNGLLSPGFFLPAAQRYQMLPQIDRWC
STEPVSGWQKVITWYTQAW
>A0A1C6JA45|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNKVLCVLRENKEIREKYFSTAKEEISDTNLHLMIWIGIFTIVIEMILLCFAKMLLPAWV
LKQEHLQMAMINLGFIFLAAKLKSIHYKNDKVVATLCMVYMLLIATCIIKIDVFYEPETL
SSFIPLLFVVTPAAFVLSLFRIYLTMILVEIEYIIALFMVKDAILVYADIFYSLAGLSFG
MLVTAIILRLRSKDNYDKLTYRHLSMTDSLTGVLNKSTALSQIGRYLLTRIDNTNCALLI
IDLDNFKKVNDKYGHQVGDRLLNQVGEILHEAFRGNDIVGRFGGDEFVVLMKNIFDDEII
ERKCEEILSLLESLTLDEENFKISCSMGAVIAKKKNESLERLFKIADDALYEAKAMGKNG
LVKKIDK
>A0A5I3D475|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Berkeley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C6IX78|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNGYFYVLTIINLFVLSFMCILTKLSEALSKKQKQGFVCAFVLIAGISVLEVITLIVDGK
PSSYRWLNIMSNYLGFGLSPAVAICLVYVLDKKTTFKREFKMAVYCELGYLIFLALSIPH
GIVFSVDADNIYSRGQYFCIYLIMYFTAILYLSISTIIKAREFQNRSRKLIYPLIVFLTA
ETIIQVMSPELRVTWLCVTLLSVLYFIYCNEMWNQLDGLTGLLNQSSYLNRTEEMRYSGG
VLIVFDVNDFKMVNDDYGHLQGDICLAAIADCIKKAYACYGYCYRIGGDEFCVLLKNGEK
EEECLHEFMNRLEERRKEITFLPIVSFGSSVFSGEDINVVKEIADRNMYQCKKEQKNRVA
SQL
>A0A1C6E4C2|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKKRIEQNEIKRYFLIIAAFLSFMILSLLFFLSWLQQDVEVSSRKTVATNVERQSYHLK
SVLDIQFNYLTGMASYMGEGEDLFCQENKRLIQSIVKEQDLDLIGIMKADGDTYYNNGAR
KNVKNRGYFKKVMQGQKIMSPPIESKVDGRTKVILAVPIYRNGKVTGALGASYNVGALNQ
MLFNDIYDGIGFSMIIDTSGKIISCDSGLSYRKIGINDNVYDFYTKSGEVAEKTMKSAKA
NIKKQKSGILVLKEKNAMSYLAYEPLHINNWMLCYLVPQSKAQEEFQFIGNKEVILFAVI
GVGVITFFILIFQRTSMKQKKMREIASRDGLTQLYNKAGTEQRIKEWLHSDRSKAGAVLM
MMDIDYFKQINDTYGHAVGDRVLYKVGHLLKSSFRENDIVGRIGGDEFLIFMEGITSEEF
AVRRMENLQQYLRELPIEELEEHTLTCSMGAAFMPKDGTTFGELYKHADEALYTTKRNGR
DGFRIYHDVEEKEV
>A0A518LN73|diguanylate cyclase|EC 2.7.7.65|Phycisphaerae bacterium RAS2|TrEMBL
MGTAESSQASGRRSPLERSLQWRIVLALAVTAFAGVALLAIQSARQQARLQSAMALQWVE
PLRAKAAMAWSDDAACTDWNIERLLDHAAVRAVAYWGGDGKRLAARALQQNDLAGLDSPP
VLDGAVPLARNFKPAGRVDKSHAYYRIDFSLPGTTKASGPRAVSAVVRLNDPPAGFWDWS
VAVGSLVAVAGIVFVLLLRWLRRNVLRPMEALRRLASTAHLETDTELAARSDELGELARA
MSDLREETATWREHAWRVERRMDSRVAEQTKSISRDLKQMQREIWIDALTGVKNRRLMQE
RLPAIFDAQRAAKKDLTIVMLDLDHFKQLNDARGHTAGDEVLAFAGELLRQCTREEDLVV
RYGGDEFALILPGMHVKESVALVERILAMFRQRTRVMTRLDPPPGMTAGIASLQANHPTT
YQDLLKMADQALYAAKRAGRGQASVSGHVATGAA
>A0A0C2S3N4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MHITNEELAGEWQRLTAAYAPAAADALRQLAEQESAELARYFYAQMLADPQSAMFLSHDQ
VKTRLSASMQRWVCNVFRAPDEPRFIEVIEQQRKVGEIHARIEIPVSLVLRGARALKHRL
RELLEEQGLDEPLRRQAARLGADIIDLAIEIMCFAFSQSHDRNSRAEEAYRLFSVSQNIG
AEKERQRAALLDWENQLMFDFAIGNTATGLPQLASSEFGLWFRHKASHAFQGSPESASIL
GYIDSIDRTLGELCEAPPSAERGDLGLLHQVREQTRAIKFLLDSLFEQANDLEAGRDVLT
RLLNRKFLPVVLSKEVLYSRQSGSTFGVLVIDVDHFKQVNDRYGHDGGDQVLQQVATLLA
SNSRGGDYAFRLGGEEFLMVLVDIDASKALQIAEKLRKRIASETLRLQKGGELQVTVSIG
MAVHDGHPDYERLLKRADEALYQAKHEGRNRCVVHSSVS
>A0A2H6B5W4|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MQQQQRERARANALGGLVCSLVAYALTVPYVVSTWDRPNRAAMLVALCAVLAEIVVISLL
PVRLAFKTPLRANLVAGLWSVSCLALVAFNASLDGGLDSPLAPLAFVPVVFASLVYGTVL
VTVVGIAGVACAAAIGVFDADARWTETFVFAGSLAVIAATCVWQATAARRRREELAQASR
TDPLTGCLNRRGFAEHFERVSAAAKRSGSRFALIEFDVDDFKRVNDVYGHDTGDRLLVQL
VRRMRTVVRTSDPIGRLGGDEFMVLAEGADREGAERLAQRIRDVIAPQVISVGMAVYPED
GETFDELYRAADRGVYREKEEHHGAAPGASPRARGRSSGD
>A0A735JQG3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAMLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F6C8Y6|diguanylate cyclase|EC 2.7.7.65|Methylococcus sp. Mc7|TrEMBL
MSQYRPTLLIVDDSPSNIRLLGGALGDDYEVRFATSGDEALRLAGRLPPELVLLDVVMPA
MDGYQVCRRLKADPATRDIPIIFITSACGEENEVHGFEAGAADYISKPINIPVLRTRIRN
QLELHRAFAELRLAASVFHNTMEGILVADADRIIIKVNEAFCGMTGYRPDDLLGLSMTML
QSDRHEAYFYDDMWDAVRRNGHWAGEIWSRMKNGESHPQLLNLSRVENAGGGISHFVALH
SDIRFLLDQARQLERLAYHDALTGLPNRRLLMDRLQHAIALSLQHRTPLAVAVLDLDGFK
PVNDRLGHHAGDAVLARIAERLSGVLRMSDTVGRFGGDEFVLILPDLEIASDIETVFARI
LEAVAEPVSLFEEDIVVTASIGLAFCPADGSEPELLLRRADRAMYRAKASGRHRYRIFDA
GWDGTVY
>A0A1E3A6U7|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MMENDKNNKSSLPEARLMQQILKARHTDLEEEKRLCKELLSVSEAEQYYYGSAFANVYLM
DSQLSMGEYTSCDFYLLRAVFLCREYGYDDLMLVLCNNAGLYYQKLNDDQTALSYLLEGK
KLAEKLGDITMLGKLYNNIGYSFGGRDDWESAGVYFRLAYRTVEDHLDEENRRSSISYLS
NIAEACRNLGDLEGARKAMERCEELGADSAYSRVRLGVSWCSYYAMCEDWDKFTEMADRL
INSDLLAVEDHFFICDMAESLCTEMLAACDEKRADRLLAIMDNLEYDNSLSLKYRIQCLK
IRCWEQFGETDKLDQAYRDYYEIVKDVSAVEDDMRIQSMLSKIQINQAMHEHEEMVRNKR
ALENASQLDELTGLYNRRYFNKLLSKMTHKEDGKKLGFIMLDVDYFKPYNDFYGHFKGDD
ALKSVARVLKDDQMDGMYVSRYGGDEFVCLCMDLEDRDIEEYIKRVGRDMEAVAIPHEKS
PGPKVLTVSMGYCNEIYRKGMDWEPVLNRADRELYSIKKKKRARIKN
>A0A1Y6M584|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MAGLNKWLRSIVLFLVFLTIVAYGWYLLGGAKKEYIVTPQNSQYKIIDDSAQKGATTATL
DIGQDHVLLECNIINKAKWPFCEIAISLTDYVDKGIDLSAYHSVGIDIDYTSPLEDERVR
VYLRNFDSTYANVNDPISLKFNAIEYSPGIDDGLKVFPLRNFQVLSWWIAENNIPVDKSS
RQFDNISVIEIATGSYVKESYYAIRLNKLVFYGEWISESSLVKALLLLWVVTAIIIIMSE
RFILDKKIKFTEERSQRLRDANRLLYNKSLKFEHLACTDPLTRIRNRHTVTEWLEEITIQ
TQSNDIPFSMIFIDIDHFKAVNDTYGHGFGDTVLVKFAETIDKLIRRSDMFARWGGEEFV
LFCPETNMSTAVEIAEEIRETIANKVWDFDREFKLTCSLGVAELVNESSEELIQRADLAL
LKAKKMGRNRIEISWEHQQLK
>A0A1E3A8V1|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MQEQLGKRVRKRINILIGLMVVVTAAVFFVVGNQSGLENTAVDFGNTEDFSRGWYYEENG
QVKYVEELPFTAEADEMIFYHKLPDSGEEPVVLSFRNRQQKVTVRVGEKCVYQYGGSSPL
RGSLLPSIRCFVPLGIQDGTETAAIQIERTVGKKIMLSEIRLGSQGAVLMEFFRESWGII
LFGVLMVVFSMGLLAGGLVLRIRSGYTEYSMFLSAGMFVLLSSLWVLSDSPVMQLLTGSS
EVVFIVSFLCFMVFPIPMFFFVESICEKKYRGLSVLKILFSFNFFIQVFLYMAAGVEFYK
MLPITHILIAASIIFTIYCLGKECRRNRSFYAREILIALFIFMATAFLSLADFYSNRKDY
SVIMRLGLLAYALILIVISFRKLILSGEERAKLKVYRSLAYVDIMTGCNNRAAFEKALEI
LRAGEEESELAGMAMIDLDGLKRVNDTYGHSMGDKMIIGAGDSIKKAFAGRGECFRIGGD
EFTVILKDKKLQEKEYRGLLEEMVSAYNDYHEIPIRLSCGFALIGTEKRDVDALYKEADR
NMYREKQKAKDKR
>A0A6N2ZHV8|diguanylate cyclase|EC 2.7.7.65|Eggerthella lenta|TrEMBL
MLHEVGKVLRSSFRESDVLGRVGGDEFLLLLKNIDLEVALDKLEQVKRQLAAVKVGSQGK
ALSVSMGVYVPEDDDLAYRDVFVKADEALYRAKRSGKNRICVHGR
>A0A1E7WDV7|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MPASTHRCAIERTTLKQISTFGSAGYQPGDLQLLRDANDDAAVARLLANCPVMRLEAGKA
VVESNQAQLYIVLRGVLAVETDSNTGMADGNGSVSKVLPGESVGEQSVLDEEANLSRITA
LEDSDILVIEADLVWKLIDQSNVVARNLLRLLSFRIRAANAQLRTRQKLGEFYRRLSMND
GLTGLYNRAWLNDLLPRLAATAHSSGAPLALIMIDLDHFKRFNDTHGHLAGDQALRTAAQ
VLSGALRPSDFAVRYGGEEMMVLLPDTNGKLAVAVAERLCERMQQAVVFADMRQPLPHVT
ASFGVATLQPQQSEQDLIARADAALYRAKELGRNRVVQEDLTG
>A0A1E7X4P6|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MRAPSIRSRLLYLVVACIVPAALMAILLIGYDYTQARAAFITGAMATARANAMDVDKEFA
TVEAALRALATSPDLARSDRQAFYAQARGLAASQHMLNIVLEDASGQQLINTFIPYGAAL
PPPSMGNVLQFVQKNDATAISDLFIGAVSNRNIASVSIPVRYLPGRPDLIGALNATVPVE
RFNALLAQQSYPEHWIASILDRGGKVVARSQDTQRYVGHKALPEVIDHMRAGFEGVIETN
TLDGKPILAVMTHAGDSQWTVGIGIPIEVLNAELNRKLLVLVLATATLLAASLVLAWSIS
NRITRAIGALVAPAMALGRGEAVAAASYGLREADEVGVALVDAARMHAQARHQATHDPLT
GLANRAMFCEFLERQVELCARTGEPLSLLYLDLDSFKQINDTYGHAAGDQLLTGAALRLR
EELRKSDLAARLGGDEFAVILVGCDAAATATVVAKLETRLAQAHHIEGYELVAGASIGVA
MLAPQGSAQQQPVSATDLVADADDAMYRRKAERKLAAKAQSLPAASM
>A0A1E7WYK7|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MDPAAPAPFRQRRPLAPVLALAQSPRVLSALVLAVSLGVTAVLWRDARHDADQELQADFE
VRVRELVNQLDQRMQTYVQVLYGVQGLFYSSDHVSRREFRTYLAAQGLARHSPGVQSIGY
MQLVAGGARAQHEAATRREPDTNPDYRIYPAGERPWHAPTVYSEPPNPLSLRALGFDAAS
EPLRRAALERARDTGLPAMTGAVRLLDDPAEAPRSAFLMLLPLYRPGQPVATVAERRAAL
TGWVFAPFRVGELMMRLGTPRTAGLMVEVHDGERATSDNLVYRSAAGAGAVTTVPAPARS
SIQQVSLGGHRWTLRIAMPHAAHLLVTDRMRLVALGGALLSVLAACLTWALARGRVRAHQ
ALARSTALAAELKDGQGALLAMADSARRSQAMLRSILDATVDGILADDFKGTILNANRRF
RELWNVPEYFDWDSDGAVLMAHLRTQLSRPEDGQFELDPLQPAALEPHGGWQMPQQALLR
LKDGRVIEQHTRSLQLGSEPARIWSFRDVTEREHGKRREHTRRRVLELLATGAPLERILE
SVVAGVEADNEDLLCSVLLLDEHGERLLVAAAPSLPPFFNAAIHGMALHGTQGPCVEAVV
SGRRVIIEDLHRAPAWMAHRDIALRAGIGSGWSDPILGAGGAVIGTFSVYQREVRQPSMA
NIALIEQAARLAGIAIEQAQAAQAVRAGEARFRRLYDHAPVALWQQDWSALYAALAELTA
SGVDDMGRYLDANPSQVARLAALVRIVDLNAAARRQVGAGPHGLADITLAQNFEAAAMPA
FAQALAALARGEHFFVGEGSFRRLDGVVRHNELTLMVMPGHTDSLDFVIVSTVDTTEKRR
MHDELRLLATTDFLTGLANRREFMHRLADEEARLRRDIGACTAVLQLDVDHFKRINDEHG
HAAGDAVLRQLGVLMLDGQRKIDMVGRMGGEEFAMLLPGTTLPAAAVFAERLRQRVAQSP
LQLGGDVRLHVTVSIGISVMGGKLPGGDAALIRADQALYRAKRAGRNRVELQDKDSIGSD
RHGLSNPAASD
>A0A6N3QND9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A5I8I0N4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ouakam|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6N3EYL1|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MGEEKRRNKKAVIFVVTFLVVNLLALSLITMWESVSVNRRLTAHAEEIGDGFDEVMDSYE
QSFKLFAQMMGREIQNNPNPDILWDYLKSIDAPLLAIEGETFDGLYMYYQGRYLYSWDKP
YSAYEETGYVATERPWYKDAVAGKGEIVFTPPYMSYANHYILTTISQLQPDGETVFAYDI
KMGDIQKLVSSTLQYDDEQIMIFDQNGTVIGSTNTDYLGGNLRASLEDTAQAVSLAQREK
EALDTTDEAGLAKAEEKIQSAAAFYSFRHSIDSGLSRVMDTEQKAVTVKLSGNRYYAYLD
RVDGYSALVLVPVLSMLKGTLEVWLVPLLIVEILLIYVLGRVSKEQKNRELKNAYIELGQ
TQRRLEIALSAAKKAAAIDELTGMMNDRSFRKEIARTLDNMDSDESGILIMMDGDHFKEV
NDHYGHNMGDEVIKLSAQMIIGRIRVVDLASRLHGDEFAIFVTDTADYAVARRIVEDIND
TIAREAKKMNIPPITLSGGAVIARHGDTYIELSKAADKALYKAKETHDGGFAC
>A0A0C7P1P0|diguanylate cyclase|EC 2.7.7.65|Defluviitoga tunisiensis|TrEMBL
MYLVLIYLTFVTFLLALILFRGIQTVKYIKRLTSNKERFFIFIPPSPKKTVINRFKSILY
ETALYCLEDEKEKSDILRIFIEHLPDFLKSDSWSFLLTPTKAHWTFLTWSKNLDFLPLED
IAYELENEGENIRNVLESNSSLFIKNVKENVTWKQENPLTVSWLGIPIKIGDEIVGVLNI
DWFKTKKFTKIEKELARSFKIEIENVLTKVFKLNELFLNFHLDPLTEIYNRKALEDYMKN
RQIITDNIALVFIDIDGFKKINDTFGHTVGDQILKTIVKRIKNVLRVEDYFFRYGGDEFI
LILKNINNHEDIKKIITRLQSIVSDTIIIDDYIIKSSCSMGYCLLPLETNNIQRAIEIAD
KKMYLQKSNLNH
>A0A379IMW9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MSDDARRWKDKYLSSLEQQEKLERRWESRLDLLRRGLVRSSLAAEGTDKAVDQCMQEMRE
ILRRDDIDAALGGLIPRLEKAVLDSEQRRQQRAGEAATALAGLIEQLQRLQPPREVRKAL
KSLGKQLQDATSHQYLLPALLSQLSNLQGQALTVLQAPVQEQPGLLQRLFGSRGESSEEI
ANTDPAPAPAPAPAPAPAPISEPEVEPATVSESAERTAVVLMPASEPAAVATLAKRKHQA
NDAAPMLDSLPLPPGLVPPEDAGDSPFSLPSSEPGYSAVAPHIASSLRSLLDELELPARH
QPQGDALRQRLEGNLNWYELVPVLDDLAVLVLAVTDSGQREFAGYLKQLNERLAAFISTL
SEAHEGYTASVESTRHFNQQLRDQVSDLQNSVQEAADLDALKQALEQRLEGLLQSVSNHQ
RQRDSGEDDVAERLQGLVKRVAEMELEAQQFRQHIEEQRQKSLLDPLTGLPNRAAWSERL
DLEIARRQRYGGQLLMAVLDIDHFKRINDGYGHLAGDRVLKIIAGELHKRLRKTDFIARF
GGEEFVLLIPGTPLDGGVQLLETLRAAVEACPFHFKGEPVTITLSAGIAEFRNDEATEDT
FERADQALYRAKGAGRNRVEQA
>A0A0A3ZAY9|diguanylate cyclase|EC 2.7.7.65|Erwinia typographi|TrEMBL
MILSRLRSTAPKKVVNGCFFVVFLILTALTWREALILKDAYEVDQRDRLNTLSNSVERQG
QRSIDELHFYRNMLQHSLEQPVLSNYALQEIAQFQRVRHQPVWRLSHSAQRSMPISGVSD
AWLQTHPLLGRGDQLRLEDELSATMDMSAILQLQDSSRNYHSRLWYLSRAGFYLSSTPPL
NDAHAFESYSKMIARPYFTGMSPSYNPQRKLAWSDLYQSLFNDEKVITVSLPVDDNGHWY
GVLAMDFRVERIRSFLLQARPKGMTGNVLFYNGHMQRIAMTDETSDPARELSAEEEKKLA
AEVAGGQQGTLRLGTRFVTWTQNQHFGSVMVNIQTLREGARGDAGRASVVLALIWLMFSV
ALVFSHQLIIRLISRMLTLQNSLSWRANYDNLTRLLSRGAFFDRAEHLAKQAQTSQRPFS
VIQLDLDRFKSVNDLYGHQTGDRVLTQAARAIQSAIRSQDVVGRIGGEEFCIVLPDTGLK
EAVNVAERVRRKLASQHVLTDGNQQLTVTVSLGVSSSDEQGKYPFESLQSVADGRLYLAK
TTGRNRVCAEG
>A0A379ISI8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MPAYFTKNEQHRRLVLKALLWITLCGGLFFSVVNLLHDNWLLAGLEIGYAAVSLYLLTIL
ERTRNLQLLTAAYLLPFFSIMIVALAQTHTTFAVFAWIQSIPIICYLLLGLRLGMYGSVL
FVGIGLFVFSRRFSSESLLQNVEIIANLGLASLAVMIFAHIYERSRILNEKRLTEQATTD
ALTGLPNRLKLAEVFERERAHALRNGTSLSLVFLDIDHFKQINDRFGHEIGDRALAHFAK
VLAQRLRINDLFCRLGGEEFAVLLPGSTAEQARDIAESLRERLAAEPLAFDDIALPMTLS
AGVASFKADGQSLHELMLAADRRTYAAKRAGRNRVISREGAGDSQAALG
>W9UWA8|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MSDGQAFPESCFASVLAVTADCVFIIKDQCIQYVSVGDEVWLQPDSIRGVSIENLLSETI
LTTLREQVSSAQASGDVSKARYIFRPEHLPELKNLGLSETIWFETRLNCVDASTYVWSLR
NINERKKLERKISHQAQRDSLTGAYNRRALIPVMEQNIAQAQRYDGICSMLLIDIDDFSR
VNDDFGWDAGDQLLRQIVTSLYQMKRTADFLVRFGDDQIGLFLPETNHEQAVLAGERARR
LVSELDIPSASGNVSCTVSVGVSSLSGPEDTAAEMMKRIIENLAIARHCGGNRVEGDS
>A0A6N2X3F5|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKQKQSIASKCSAFTAGLVILQSLLVLGMLIAGGILKQTRDTAYQSFASTVTLRASSIQD
QIDNRWTNIHPYVQELSDQLSESGYGEGKMDAESFLIGSADTLISMLHVSGTTGTFLILD
EPGQGKSMPALYFRDYDPETYSADNSDLFQVMGPAEVSRRYQIPLDSVWHYGLSLNEENR
KFFDMPFQAAGQSRDYEKLGYWSRPFHMTPEDVPVITYTVPLFDRTGQVHGVIGVEISLE
HIRKLLPANELSAQDSPGYMVAAMQENPQELFVLVKKGEYQNRLFGDEPLLRIKQEDETY
SICQVSSLTGEKIYGCIKSLDLYGTKNVPYDSGNWVVLGLMRGDALYGFLHRIIKIFAVT
LMVSLLLGAGAAGFISRKITEPVAKLAAKVRNFDYTRKIRLERTGIEELDLLSQAVEISN
QNLLDNTLKMSEIMDLLGLHIGAFEYSPGGYGVQVTKQIFPLMELPCEDENHLYVDEKIF
LSRLSDMQRCPVPEENGIYRISGKTERWVRITLSLRHGHSLGIIEDVTGDMMKKQRIKYE
RDHDSLTRIYSRAAFQREAEAILEQAGEMPGQTGEMPGLSGNGPVNLGTAAMVMLDLDGL
KSVNDTYGHESGDIYIRETAVCMKGIPEDHAIVGRRSGDEFFILLFGYEDRNCVRKQLRD
FYDILDKHPAVLPDGIQLKIQISSGIAWYGGELCTFEELVRCADIALYEAKSTMKGQTVE
YRKG
>W9URE8|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MQYSDNSQQAAEYLRQAVPLMVKYKIPPHPLNYALWYTYVTHKLPRLNQELDQTIQKYGT
CPAGLETKLFRSHLISQELGETEKLQAALISVATGLNHSAELAVASTHDFTQLLQESLHA
LHEADEAPALESIAQSLYSHTVKVSEATSHFQQRISDAQKEIKRLQDELTATRQDVYTDA
LTHLYNRRFFDETLTRVCNSTPKPLLALIMLDIDHFKKLNDTYGHMLGDKVLQCLGQIIK
DECHESADGVRFGGEEFVILIYEHNQENALALAERIRHKIQAIRVKHKATNSTISSITAS
FGITLQQAFDVPERMLERVDQALYQAKNTGRNKVVCI
>A0A7W9C3J1|diguanylate cyclase|EC 2.7.7.65|Brevundimonas aurantiaca|TrEMBL
MSARILVVDDVDVNVRLLEAKLTIEYYDVLTCHDGQTALTLAAKEQPDLILLDVMMPGMD
GFETCRRLKARAETRHIPVVLVTALDGRADRIRGLEAEADDFLTKPIDDVVLLARVKSLT
RLKQVMDELREREESSRRMGVGDEAAARLRTEGGRVLIVDDDESQAAAVAAELGREHRVV
VETDPQAALAAAKGPLDLIIVNVAAQSFDGLRVVAMLKSGDARRAPVLAIVEPSERPRMV
KALELGATDILPRPIDTEELSARVRTQIRRKRYTDFLRQKLDSSLEMAVTDSLTGLHNRR
YMAGQLQALVGRATHGGSPVAVLVLDIDHFKAVNDGFGHDAGDEVLAEFAVRLATNVRAV
DLPCRMGGEEFVVVMPGAGLEDARMVAERIRRDIAAAPFRVMGGEEFLTITLSIGVAATT
GAGDTPEALLKRADEGVYEAKAGGRNKVVARAV
>A0A0A6ZXC8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MAKPLANARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDV
RSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAQNAQLLRTALHDPLTGLAN
RAAFRSGINTLMNNSDARKTSALLFIDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGL
RHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTI
EHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7W6CUT7|diguanylate cyclase|EC 2.7.7.65|Rhizobium metallidurans|TrEMBL
MTARILVVDDIPANVKLLEARLIAEYFDVLTAADGYQALAICERNQVDLILLDIMMPGMD
GFEVCERLKSNPKTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLIARVKSLL
RLKTLSDELRIRAQTAHTMGIDELLRADQRGEEGGQIMLVDGRANSQERIIKALKPIGNV
FAISDAQAAVFEASENQFDLVIVNSNIDDYDPLRLCSQLRSLERTRFLPLLIITEQGDDE
MVVRALDLGVNDYIVRPVDPNELVARSLTQIRRKNYNDRLRANMQQTIELAVTDPLTGLS
NRRYLDNHISTLFNRSMARGRPLSVLIADIDRFKQINDTHGHDAGDDILREFANRVRSTV
RGADLACRYGGEEFVVVMPDTSPEIAASVAERLRGVIESVPFVVKGTGEELQVTASFGIA
SRTPQVITPGHLLKQADVALYEAKNAGRNRVVAAA
>A0A7Z0ASD6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas moraviensis|TrEMBL
MNDLQIDDIKTDENAAMVLLVDDQAMIGEAVRRGLSNEENIDFHFCSDPHQAVAHAVRIK
PTVILQDLVMPGLDGLSLVREYRNHPATKDIPIIVLSTKEDPLIKSAAFSAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYLELEWRRSLRDQSQLSLLMIDVDYFKSYNDTFGHVEGDEALRKVATAIREASARP
SDLPARYGGEEFALVLPNTSPGGARLVAEKLRQTVAALKIPHNAPAEGSSLTISIGLATM
VPESGSDCRLLISAADRGLYLAKNNGRNQVGIE
>A0A7Y9W2T2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas moraviensis|TrEMBL
MSVAMYPLDPPAWVWALMLFNGLVWPHLAYQWARRAKVPYHAEHRNLLIDAFLGGFWVAA
MHFNPLPSATTISMMAMNNVAIGGVRFLLAGAAAQLLGVGVGLVVFAPAFVPMTTPAQLY
ACLPLLMLYPLALGWICFRQAYTLGLHKRELLALSRTDSLTGLLNHGAWKDQLEIEFERC
KRQQTGAAIALIDIDHFKAINDTYGHVAGDIVLRQLSKMLKQNLRMADVAGRYGGDEFCV
ILPDLPLFNAAQAMEALRERFSFLVYEQNPALKVSLSIGLAALDPAHGDATRWLDDADQA
LYEAKAGGRNRVICCSDDKPRREVFDSV
>F5NWS7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLAN
EAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSL
QSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKE
RLHITLDSIGEAVVCIDMAMKITFMNPAAEKMSGWTQEEALGVPLLTVLHITFGDNGPLM
ENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKML
RQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAA
GDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFIATRIISAVNDYHFIW
EGRVHRVDYLD
>A0A7U7J3Z2|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MKSDESGFVLASAAQARTGQDAAPPANAAMTEPLSSASAPGQRQRILALVIGYLLLYFGA
FWAAALLDQGGLIASLWYPPAGLTVFGMLAFGWAGVALDVAGSFLTLLILETAQGASLSA
DQVLSELIYALFHTAGYAAAVLPLRHWVRSVGSCLAQPAQISGFLFAALLGAALATGINL
IWFYSTRLSDFSPLSIASTWLVGDFIGIITFTPLLLVFLLPSLNQYRQQGRWCWTGEPAV
KVSGSAHHSILADGLMLVTMLLMIFGIPWSLEMGRHFPFAALLLLMPLAWFTQRHGLRGA
VLGTMLLSSGLVVLVALLNPSDYTLEYQLVMIAIALTGLLLGGAVETRNQAQAALQVQAM
RLEQDVAARTEELQRAYQELASKEHHQRTLVNAAPVGIAEFDAQGYCRYLNPVGCALTAC
NLEAAWGRHIFEFIHPDDRDHVEFIWQLNATYAGVNQLEFHLRGTDFWVSAHWINLFKVG
QPFVGSIIIFVDNTEQRRKDQQLWFQAHYDALTDLPNRNLFWERLTQNLHRAKRNHQNVA
VLWIDLDGFKAVNDTLGHAAGDEVLQQVAHRLSGRMRDSDTVARMGGDEFAVILPDIGEI
GAAEQVAADLTVLLAKPFALKGGVGHISASIGIAMYPLHTEDAEVLVNYADTAMYFAKNA
GKNQIAVWQPDI
>F5NR97|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTER
AKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNEIYRLADNALYEAKE
TGRNKVVVRDVVNFCESP
>A0A751D2P0|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICVALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A745QVZ4|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAK
>A0A142WNP5|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL14|TrEMBL
MSPFPLLTVASLAPPAGWLAFGGIAAAIPVVVWDQIRRVRNRSRDWEQLQQSLDNARARE
EILAAELRLLYCVLSPGAIDDRLRRLQSATREHDAAEATAVFRHRSGVLTLVHSHELSAA
TRQRLSISPAILPQLTRHRILHRSLISQSSPASNGASPLVGGLDAAARAALSDVILRPIG
DPAHPWGVLASFLRHDHEDPSPADEALWSRVLTLLGDELRREEHTTQRDSELSVSREILE
LRGVVDQHFHGPAQMVLEFLRRLALLADFERVTVHLFGAQLTPESSVIRAGAALPRPLGE
AWILAEDRLLPRLAQTRGLHIHDAQHLDQSTAPLPFATVVSVPIERQDAAVGLLCLTRRS
GSHVADADRSLIEWAARYLVDLLTQTVDRARVAEQARLDPLTLLPNRRTFDAEFSALLER
SGDREEAFSLLLLDIDHFKSVNDRRGHPAGDAALQAVAHVLQRVLAMTRESDQPLAARYG
GEEFAILLPATDGPGAVRIAESIRQAVERTPIRFEDQEFRVTLSIGAATFPDHARALQRL
LKSADTALYQAKRDGRNRTRTFQAESVAAGT
>A0A5P9CAJ0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MATQTARLLKRLRNDFQLSIITLMGLFGIIGISPYAVYRLLHGNYLVGIADTVIVLSTLF
AVLYAWATRDTVKPGIYLAGVFSLGATLIAINLGVNGLFWIYPLILFNFFMVTPGKALLA
TSVVLVSLVTYALLVPGSVFESHYQMISFLVTCMMASVLSFIFAFRTRNQRDRLQLLAIH
DPLTGARNRRAMNEELKIAMASHRRHSDSYGLLVMDLDHFKQINDRFGHHVGDQVLVAFV
ELIKRCSRKEDRLFRFGGEEFLLLLPNTGLEGLHTAAQNLLRSVQQELESPGGGVTVSIG
GAILHSGEHWESWLQRADECLYRAKSEGRNRAVIADAPGHPDKLAANR
>A0A5P9C8I1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MVPPSRSNTIDFDAAKLQRLGFTGNRNLPLKPASLVELYHQLSLQLQTSLDAERILNLFF
REVQRLVPLDALAFQHPSQDLRLELGERAPHSAGYRLSHEGEYLGELIFRRKQRFSEEEL
MQLEALLACLLFPLRNALLYRTALQSALRDPLTDTGNRIAMDQVLQREVDLARRNLQPLS
LLMLDIDHFKSINDNHGHALGDEVLKAVAQTLKNQLRNIDMVFRFGGEEFLVVLSGTSRE
GAALVGERLRFAVMELQCLDAGRPIDVSISLGCACLLPGESSDSLLRRADNALYVAKREG
RNRLSMAG
>A0A8B3WNA6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MALPKTLIRLFKPYIILLTGGMLYLAVAQLEKVETAATEQSSSNIRIASSTIRSNIEATF
GKLYFLETSLGLPQTAPIGDRKFRELSDNILKRTPNFSDIVRYQPQTQQYISSRGLPLSN
EQVGSIKWNPIDSVVEDFYISSIYQKPDGRWVFAVKHTAERLNEEIWIEFDLLHTTQGLR
DLKTLNHGYVFVVDRATERLVFHPNPKRIGSKSISYHAGISHQLSQGETVGKHEYYYQDN
FKISVFDADNSLNWVFIAGTDRHDILTSSYQFTLTGVVLGSLILLWVGANYLSYRLNVSL
SQLNKVDDLVSFKRELKSILASFTYQKGIQFCLYQPENHAFSTIDYHGNKSTVHCDKALA
ERFTPDTMAYRSGKYADPLACKLKIHQRHYCIPLHSRKQLVAVLYVNANLPISQSILRMI
RDYTEVSLSNLLLHHQLSSKDLMTQLDNKSSFNIALENYADEPDTYVALLDIDNFDHVNR
AYGEAVGDKMIKLTAEAIRSYFPKPKGLCLARIGGKEFAVLFKANDVKDAKFQLDQCRIG
VNEQAVATPDITLSLGVSVGFSQIVGETDSALALAEQAKLIAQQLGKNRVEGHIRAVAQA
S
>A0A550AGB2|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MRSFNILSNYVLLLSILVGMTLSGLVGYSFYQNETLAIELDFKRDVDDKAAALERELLIN
LEVLYAVKGLFDSSDNVTEIEFKKLASSFLVRHQNIQALEWIPRVSDDERETFEALKRQK
YPDFEFTEREFQGSMVKAAKRSEYFPVYYVEPLEGNEVAVGFDLASNPKRETIIDKSRDL
DLSLATASITLVQEVSNQKGFLVFMPTYEGTPTTLVKRREKLRGFVLGVYRIGDMFETAI
KYTDVQGINLKLIDNTAIKAEELYINFSPEQVQDNTQLHLTYSKPLRRFGGRQWTLVTSP
TLGYIAERRSLVPFLISALGMLFVLLGACYIYAITRRSSLISIEVEDRTKALNEASLALE
ELSYTDSLTSIANRRRFDQQLSKEWQRAIRGNTRLSLIVIDIDNFKLFNDQYGHLAGEQC
LIDVSKALSCTTSRNTDLVARYGGEEFVILLPNTNESALLADKCRMNIEKLRIPHEPSSV
SEFVTISIGAISTFPTLNCDPIAFTAKADRLLYQAKELGKNRVCVEDLPISKTGDVIDFK
APQK
>A0A383RNK5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MANKNPPAPPTHRPPEVAQTLLALLHAQGEVARLSEREQLFSSLLDSVNAVLWAFDWESR
QVLYVSPAFERIFGRPVSLVLADYNEWRDSIYPDDLEYAEHSMAQVLVKGAVEDREYRII
NAQGEVRWLSDKCFINQQREGEDRVIIVGIAEDITDKKQLEGELQRLATTDVLTQSSNRR
HFFECAQQAFDTAREDGSALAFLLLDIDDFKLINDSYGHQEGDQVLQRIADSGKAVLRRG
DQFGRIGGEEFAAVFPGCTAEVAEQIAERLQREIQRLSFTHGQQAYGVTVSQGLTGLTAA
DDSLDSLFARADAAMYQAKRQGKNQIVRG
>A0A1X1F183|diguanylate cyclase|EC 2.7.7.65|Pantoea cypripedii|TrEMBL
MAQSPLPRQSDHPFLRVHLCFLAVFLFSALLTVHEALELKANYEDRQRAQLAEIQKSLDS
QFQESVDGLVYYEKMLNYALAHPLDSDNAREAVQRFERLRQQPQWQLQLESPRSMPLNGV
SDDWLAHDPLLQRDPTRISQELRAALEFSFIMQFSDPDQDFHSRFWYISRAGFFISSRPP
QSLQELAESYATMVQRSYFRSQQPQANASARLRWTTAYQGLFNEGLMLTVSAPIISKGYW
YGVLSMDFTQQRIRELMVETRHTLLQGKLILMDSSLNEVTRLYAPDDEALEPQEQQQLKI
LMAQHPSGILRLGTQFASWSRLKNVDTYIVNVQSLKQGMQQELGRVSLFLFGMWMLFVLL
LVVAHQVIFRLVRRMDDLSARLTWRANYDGLTRLLNRNAFFEQFVAQAARCQQQGQPISV
IQLDVDHFKKVNDTWGHHAGDQALIRVASVISHTLRKYDSAGRIGGEEFCIVLPETRLEE
AAAVAERIRARLAAKTILVNASTTFNVTLSAGVTSSEEQDDYHAESLQAKADSRLYLAKA
SGRNRVCSED
>A0A3G2IB22|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. 3AFRM03|TrEMBL
MFGDAIQREISRFKSPGKVVNLCFIVVFIFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHNIDSLLFYRNTMHYALQSPISTDRTRKSLAEFDLFRTQPFWQLRLDLHRSLPM
NGVSDEFVNSSPLLERDDETLHTELSAALELSYIMRLSDRSRTLPQRIFYASRSGFFLSS
TAPVNDPKIVSLYYRLIAQPYFSSQSPQNNPSRVLRWTHTFNPNSTSGQIITAAIPLDFN
GRWYGVLALDYPIDSLHSFLQQAKYDDHEGTVLLYDNELNPIATSAKRMPKHALFTAPQL
AQIANAVTAAKPGEQGELRLDTRFITWAKLNNFDGLLIKVHTLEEGVRGEFGRISIVLSV
LWLLSTLMLFVSWMVIRRLVSNMFSLQQTLSWRANYDTLTRLYNRGAFFEIANKIAQECK
QQAQPFSVIQMDLDLFKSINDRFGHSSGDKVLTHAAAMLSDAFRQGDVAGRVGGEEFCIV
LPDTTLEEAVKVAERIRVRINSKELLLKQGNTTRISASFGVSSALEFNDYDFERLQSYAD
HRLYKAKQGGRNQVCSHD
>A0A809G6I6|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYEDLPLLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQALSNQQQPGETERMSLLQDIRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRRPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELRIAASMTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETCRE
>A0A6N6K7A0|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MSKQFQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGDSLNYTYTTINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLALGSAVIPPLLGGALMWLLLPEGTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STILMVSLMLAANPSLLYTPKANVMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNNDL
EQLGMLVRGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPPHIKPSWQVWYECVV
PEDREHAENVIRDSLAARIPFKLEFRIAVRDGVRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDADMNVTFMNPVAEKMSGWQQDDAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGGSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHDTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
SGRIINAINEYQFRWEDRLHRIGASAGITLIDEKNYIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQTHVSRELLSFDEQKHIIAHNPMLMIARGVASPRIPETFSFWLLSLRLGTED
GDVIEEHILRTGLVDPALNHALDRRVFNEFFQHAAAAIASKGLSIALPLSAAGLLSTELV
DEMLAQLQRSSLPPRLLHLTIPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVE
NLKFHTVDYLLLDSEISASVHGNLMDEMWVSIIQGHAQRLDIKTIAGPVQMPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A7X5G2Q3|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MIRRTQEIDVILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDISGDDSHAVCQFGQWLKD
HPQHDDDECSYVSNIHATHEKMHLLGKELLLAIVEDRSHSWHFDSFQDALLGFTSAVMDY
KIYLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDMVLRSLASNLLAWTRYDEVAYRYGGEEFIVIIRTKTDEQACQAGLRLCHLIGQKKIPY
PEGEIGITVTAGITRVQQGETLDNGLGRADRAMYEGKQTGRNRCMFMDEKEKITLVGTND
QLTPRVRA
>A0A0E8C3Y6|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis|TrEMBL
MRKIEALAMWIATLIRVHRQVERLTHLSRTDPLTQIMNRRAFTESFQTRRLEGERRRAEV
GTGLGFAVVDIDHFKQINDTYGHDVGDVVLAFVGKMMNEFFRESDCVARFGGEEFCVLMQ
DVDEGGMQRLLERFRVALGDCVVTHSAGTVSITASIGAVLVKTSVAGIDRAFRSADLALY
KAKADGRNRVRIAPSAEQSHAGNPANRLCYPG
>A0A732CWE9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 18:z10:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLYLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1G6SA76|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. YR651|TrEMBL
MPWRKLLPRPRWLPRAVLMHPARLVVWCFVVVILMMLVVGARDLFLLRERVLTSRQHDLT
LRVLGVEAVLAAERYKLTFVRDYAQQQITIQESAAARPPDAAIEAAYAARNQPVWQLAVP
NEDSSIIGVSPQLLSGLEGFERRDADLRADLYAARQLSHVLGLNQRNDATAGAVTFISSN
GFYITFPPLAADKAPALLRRLNGMPYYRDLLPDRNPNHELRWSSVYTQFESTQQRTTVSV
PIYVDNRFRGVVAVDLSLRQLRTLLGTPDDADATRYMLDRKGKLMAASTNETIRDLRWPD
ALGEKWKHLTLAELFSARSGVRQSGGEYLLFQTGDDGNWMLLDTLKSDDLNRAVLARMSQ
PLLVIWFLLPLLMLVTIRVVTLLFDHYMALGEKLQQLAEHDPLTNLANRRHFSDLFRRES
ARRHREGHPLATLMLDIDYFKRVNDRWGHASGDRVLQRLATAVKENLRAEDTPARLGGEE
FAVLLPGATLAEATATAERLRAAIAAIAVEPAPDAPPQEGGDGRIHFTISIGVAEAGIDG
STTLDAMLATADRRLYAAKAAGRNRVCASDAPAGSVAAPTVQG
>A0A6M8MEZ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MDNQTPHVETPAAAETLLALMHAQAEVARLSEREQLFSSLLVSVNAVLWAFDWQTQRMIY
VSPAYERIFGRSAGLLLADYSEWRDSIYPDDLDYAERSLSEVLEKGSIEDREYRIIRADG
QVRWLSDKCFVSHQVEHSQRLIVVGIAEDITEKKHLEDELQRLATTDVLTQSSNRRHFFE
CAQREFEQARLQGTPMAFLLLDVDDFKLVNDTYGHQEGDLVLQRIAECGRKTLRRGDLFG
RIGGEEFAAVFPGCAPEMAQQIAERLQREIQRLSFQCNDKTFGITASQGLTNLGEQDQSL
EALYARSDAAMYQAKRQGKNQIVLV
>A0A7S7C001|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MADQPEHPSRPRGGLRRLLPWGGTDTARPAAALPTVINGERGGHGLAAHQLVPAKAKSGA
HDPAAATALLIRLFSHAAHPEALLLAFAEGIASLHGELGDMGVRLSAAYAAGDWPGYGRA
LRQLIDKYIRTIDIGDSLAEGRTEAEQLRDLLRHALGNALATLLQRSPELAEEAQTLASA
LRHWRPGHELITLEQRLRELSHQIGLRAEDASEQQNLLLGLFDLLLENVGELLDDRSWLQ
GQITVVRQLISGPLDVSSIEQARGTLREVTYKQGLLKQGIAESKTAMREMMVSFVDRLDG
MATSTGEYHDRVAGYSQAIGEARGIPDLNRLLQDLLQDTAGVQAQALAARDELLAARRQV
EDSEQRIASLEQELKDVAGLVREDQLTGALNRRGFEELFQREAVRTQRSGQPLCVAMLDL
DDFRRLNETHGHAGGDAALRHTVEVAKAVLRTTDAIARFGGEEFVLLLPDSTIFEASAAV
IRLQRALSQRSLLHDDVRVFISFSAGVALRGTDETQDEVIRRADRAMYDAKAAGKNRVIN
AD
>I6CXS5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEE
FVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDA
LYRAKNDGRNRVLAA
>A0A5C6DVD6|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MLKLYLATIRFALAIFCIAISFVLGAKILGFLPDLIHGNSRLIIRWAIGLIVSGIGVYSL
LIARLFSSMKVSQLVASRVSQSLDALTEGLVVIDENERIVLANRAFSDTIGVPQPKLVGR
RVSSLRWVGSPTATVHDCPWVRASEQSWRQTDQRMRYHHPDGSFRVLCINASPIKASDAT
PGGVLATFRDVTMMEEHHAELEQMVVMLRNTRDEVCSKNRELQVLATCDALTGCQNRRAL
FAFLDKAWARMQQEGTSLACLMFDNDHFKQVNDTYGHQIGDEVLQRVAAVLQEAFPEPSI
ACRYGGEEFCVVMTDVTESQAVAAAEQARKQIEQLRFEEPAELRVSASIGVSMSEFGARD
PQEMINQADRCLYVAKEQGRNQVVAFDEVVDQSTQSSQCVGSNATRKSHRPTETVQGIVA
LLDAIEGK
>I6CVD8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVL
LDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGI
RVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHLRLYQNVSRENISDAMTGLYNRKI
LTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSD
YAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDA
YKASDERLYVNKQNKNSRS
>A0A174HRY2|diguanylate cyclase|EC 2.7.7.65|Lachnospira pectinoschiza|TrEMBL
MLCLAFVFFVLAIFIVQIFITKNVLAPIEQIMNVFNDIKATQDYSKRLPKSNSVEMNQLS
DEINGLLTHIEDENIQEKERQRHLRELAECDPLTGINNKKAIEQKMLAMVQSATDKKVRI
SVGFLDIDDFKDYNTNYGHQEGDNVIKFVANTLKENFKGEVGRNGGDEFVFGYEGDISKE
ELDRKVKKVYDILNKGYTRGDLLKNMSVPCSIGIVTAIGGSFDYAKLLKEADNAMYDAKI
NGKNTYVIREL
>A0A7X0DI48|diguanylate cyclase|EC 2.7.7.65|Rhodanobacter sp. MP7CTX1|TrEMBL
MSEARIVVFLVDDQAIIGEAVRRAVENEPDIEFHYCSVGAEAIGMAAALRPTVIMQDLIM
PDVDGMTQIHLYQMHPALRHVPIIVLSSKEDAAVKSLAFATGAVDYLVKLPDSIELIARI
RHHSRAYTNQLQRDAAYRALRENQQQLMQLNETLRRLSDVDGLTGLSNRRNLDAYLESEW
RRAVRDREDFSILMIDVDNFKLYNDTYGHLAGDEVLKQVAKVMQECAHRPADLVARYGGE
EFAMVLPSTLQAGAKRVAERICANIRGLSITSDASEGMCVTVSIGGATAVPSRGESYTPL
LEAADAALYEAKRAGKNRVVSHELD
>K1LNQ5|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MVIPMQELQMYQNFNELASDVLELAKEIMPDKLIYLSSFTENEQVILRLSNADSHILLSE
GMAVKLNQTACNQIDFENNQPLIYEDISKETDFEELKKISGKININSYLGIPISLTNGEK
FGTLCVVHHDAAHFDTKSISLLQKIAKIFSYYLMLEKLAYKDSLTGLYNREFLFAFFKEY
SELGGTLFFLDLDGFKKINDLYGHDAGDQILKSVSSKIKKFIKHHVNVFAVRLGGDEFII
NLPHISSKEETAKQAEILLEYLNTWDNEYQLSASLGIVHYTAEDTSALETILKHADKALY
QAKLAGKNTYKFFEA
>A0A4P6LSM9|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MNRLDQNISLANRNGTLIGIMFIDLDSFKSVNDTMGHTAGDIVLKSVAERFEHCLRREDT
VSRFGGDEYLVQICNLDKI
>A0A6J4G0U6|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MDGGDAIIEQAAVGTARQDGHAPDQYRSLFENAVEGIYRTTPDGRYLAANPALARIYGYD
GPEALVAGLTDIAHLLYVDPADRDRFTHLLEHHSEVRNFEARVRRKDGSVIWIAENARAV
RDPAGAVLCYEGTVQDITERKQTEERLRLAAAVFDNVGEAIVVTDGDHVVRAVNSAFERM
TGFTAEAVIGLKARILATEVNDPDLVAEAFATAAIGGIWQGELWARRADGDVFPVSAALT
GIRGPDGGVQTHVLLCHDVTRRKLDEQKIRYHASHDTLTRLANRHTVMEALRDAIARAAR
TGQRLALLFLDLNRFKDVNDSFGHGAGDDLLRQVARRLKSCVRASDIIGRLGGDEFVVAL
PTITDPQGAVACAEKVVYSFSDPFTLAGRELYTSASIGIAVYPDDGDTAEALLSSADAAM
YHARASGRPYRYYDQEMNRQAVDRLNLENDIRKALADRQFRLHYQPKVERGGTRIVGAEA
LIRWRHPERGDVSPAMFIPVAERAGLVGAIGDWALSEACRQMAEWRARGLEFGCVSVNLS
PAQFHDAGLKDKVEAALKATGLGADRLELEITETMMATEVDRAIAILSDLGRMGVRVSID
DFGTGYSSLAYLKLFPVNALKIDRAFVSELPGNGKDGAIVASVVALAANLGFEVIAEGVE
TEAQAAFLIERGVHVMQGFLYSPAVDSETFAGLLAQGF
>A0A5E1AVM0|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MTSQSWRSLVNSKYQLSLRLFLFLNATSAVFSVTNPLYSVQLLSFPLLAIFTLSTGLLLW
HWQKSTRKINIPVVSAIFGILWAWQIASKFSLITHDRATYLIMALLTVLFIGSLAFAINI
KAFTLHSLPAFIVCLWLSPSEHWLRMIYSFILPVVAIGVHHVLQRRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPAVENGEHFVLLMDIDHFKAYNDYYGHMMG
DQALIRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARQTAERIRQKVYDLKIPHM
FNERVATNVTISIGIAIFENEDAEGALEKADKALYEAKHLGRNNILLSEELQAV
>A0A246KIW1|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MFQSLTSRIAAVSALVVVALLVLVAALADASRQTRESFRWVTHSAQVIQAMEETVAGLRD
AESGQRAYVLTQNPAYAQSFDARISDSLRAFSELVELTRDNPSQQLRLQALGAQLSGRIE
LMRQPLTLARSGDFARAEALIAEGRGFDSMSAFVLAARELLDEERVVQSRRVEAAERRLA
RVRGLALIGGPLIAFFSLSVSLMVIRGIRQPVRVITRAMTGLGAGDLNQRIDSRMGSREF
DRLARGYNDMADRLATAAKDQSRSERELKRVHEELLASAQTLRERGEVIELLGGMAHRMQ
AARTDDELAQVIHAFVPRVLPGLPGALYAYNNSRNLLVPLSGWGGHEAETEGFAPDQCWA
LRRGQSHFVSEPGADVVCGHVNPLAAPYHCEPLLASGEVIGVLHLDGLVEAETQFRLNVL
AENIASAMVNQKLQRDLKEQTIRDPLTGLFNRRYMEEALALEVARAARSGAPLCVVMCDV
DHFKRFNDEFGHEAGDVVLQAVAAELGHRFRDGDIVCRYGGEEFIVIAPGTKAETLAPRV
ETVRQAIAAIALRLGKQPLGSSTMSFGVAEWSKGMNRDGDALVQAADAALYRAKKEGRNR
VVLHVEETA
>A0A098G111|diguanylate cyclase|EC 2.7.7.65|Legionella fallonii LLAP-10|TrEMBL
MISIAGYIIHEKMRHNHNIDTYYAQRQKDKRKVLLKIPSNDSAPSENFAILQHEFHLLKM
IETPSIIKAYDFLQNNSVPALILEGVKGQLLCSYIATNLMQLGDFFNLALQLVDIIGELH
QRNIIHKQIKPSNIVIDPKKLTLKLVDLSASIKLSEESFNYLNLIEFKDSLAYISPEQTG
RINRPVDYRTDFYSLGVTLYELLTNQLPFQTKDALELVHCHIAKKPPTVLEIRHDTPKML
AAIIDKLLEKMPEKRYSSIIGLKSDLQECRQRWLQENNKNEFFLGINDVKDHLTISRNLY
GREQQVLHLIEAFNRVSLGTKEIVLISGYSGIGKTSLVKEVHKPIVQHKGYYIHGKFDQL
QRSIPYSAIVVAFQNLVKQALSESEERLVVLKNQLVQALGNVGQVVIDVIPEVELIIGSQ
PSVPILSPADAQTRFNLVFQNFVRVFAQTEHPLVIFLDDLQWADNASLNFIENLLQDGET
NYLLLIGAYRDNEIDENHPLQLCINNLNNHEVPCTSLTLQPLQLENIQQLLEDTLSGALE
KIPSLVQGVYDKTQGNPFFINEFLKIIYQENILFFSYENGVWQWDLTKIQQQSATDNVIS
LLTTKIHLLPKLTQDVLKLCSCLGHQFDFNTLLVISGQTISQTATQLAQAIKANLIYPLE
ETYKTLGLVGLDDSMIELNVSALHYRFAHDRIQQATYALIKGKDRPEIHLKIGRLLLKEK
PLEEHDERLFDVMEHFNQGISLIEDMDERLLLAKYNYWSGLKAKSAAAYDAANEYLMAGV
TLLDLENWNENYNLVFQLHKELAVCKYLVGDFAAADEYFSELLNRARNSLDTLEVYKLKI
EMLSTLGKHTEALAMGISALHNFGIKIPNKPNITHMLTAIYKIRFQLRKTKMANVYLPPM
TDLKYKAIVDLITQLLNSAFITNQQLFVLLTCKNISLSLKHGYTESTSMSLPVYAFILMH
SLNLYDEAISVVTFYNRLKKEYGSSNFEGKNQFIIGSFIEPYQKSIVACNKAVVKAFSLC
CEVGDLVYSNYSNLVLVIHSFSIGKNLTEIKRSIQATLTFMSRIKISDFITVAKFWDYLT
QCLENSELADIDRAAVFENDILLGKSKTELSFFYSTLTMLYLLSGNFTKAIDAGKKHELY
SDYNKGLMIHLDGKFFYALALFFYLPQIPKNERKSSLKLLKKLQRFIAKHTAWCPDNFKA
YSLFIDSEFARFEHQDQHVLALYEQTIEAALATGLMLIAALASERAGHYCMNQKIERVAK
LYLQNAHRYFKEWGAIAKVELLEDTYSCLNNDHHHLNYKSALSNQLLTKTNTQELDMLAI
FKFTQVISSEIRLDKLLQKFLIIVLENAGAQRSIILNRMNDQWVVEAEGNLEQQTIYLNN
PIASEVSANYPVSILNYVQRTQKPIILNDAIQSDLTFQDAYVQQEKPLSLLMMPLFYKGQ
LSRILYLENNSSSYTFTPNHLDSLQLLAAQAMTSLENAKLYYQATHDPLTGLANRNLLYD
LFHQITKQANHVQERVALLFLDIDYFKVINDTLGHDNGDKLLIHVARTLNACLREGDVAA
RMGGDEFAVILANNPSTEQIIAIVELLLREMARAVPIDNHSIQITSSMGISIYPTDGHEI
QTLLKLADTALYQAKEKGRNQFHFYTTALYEDYQQSHGLGRDLQRAYDKKEFFLMYQPLY
HCRTGQIIGVESLLRWNHPEKGIIPAGDFIHTLEKSPLMIPISEWVIKTACQQAKDWYEK
KILPGSVAINVSAVQFIRHSVSELLANNLAEIQLDTSCIELEITETSFIEYTDNLNKEIT
ALKNMNIKLVIDDFGTGYSSLSYLKHLPVHKIKIDKAFIKHCDNDYLDQTIISAVTNIAH
KLNIKVTAEGVESEGQLKFLQDQRIDEIQGFYYSNPMIAEECEIELKNSSLI
>A0A098G5I6|diguanylate cyclase|EC 2.7.7.65|Legionella fallonii LLAP-10|TrEMBL
MSDLPPVPDNEQVLREEIKRLNKIIKALIDRAEQDMNAPNSDFGVFQTTIMLEDKVRLRT
KELEEALHKNAKITRALQQASILIEESEQRLHDITSALGEGLLVMDKEGSIMFINAAACK
ILLLNEDEVLGTNAHELFHHSYSDGSPYPIQQCMNLSVLQTGQPYSSEDEYFWRSDGTGF
HASVIATPIKLKENTQGVVVAFHDITQSIQERNQLRDMKAAIEQSPASVLITDKDKNIIY
ANPELMRATGYTKAELQNEKASIFHGDLTPGDNYIELWKTILTGAPWNGEILYQRKDGST
FWQSWKVAPVMDNHGVIQNFVAVGEDITEKKKLQTMLQEMSYQDGLTGIANRRRFDEYFS
QEWNRALRHGQPLAIIMADLDFFKSYNDSFGHQAGDECLKKIALKLKSNILRLTDLLARY
GGEEFVCVLPGTNLAAAKLLAEKLRLAVCSLKLPHPNSTVSPYVTISLGVACCSPCEDMP
NNLLKAADAALYQAKTLGRNRVEVATDF
>A0A128F3X8|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MILRWLNNLPLRIKLVLPTWLLMTSGVVLLGFAIEKIAEDKMEQSLIGRTEILTNAAAVN
LTAALAFEDQRTAFEQLEALRVDPDLIGARVLKSNRTEFASVMDLPSDCHPTDASIMCSD
TNFERVKKPIVLGQEILGFIEVYVSREAIEEERHFLVGYLTAGTSLLSLLALVFAQMLHR
LVSHPLASLHQSMSSMLRLGVFGRAIPVKHKDELGQLTACFNDLISNLSERDYQLKQTLN
QLENKSQYIGEVLDTMEDGVMVIAPGDVVTYFNPAAEYLLRRVNCSPRNLTKLLRTFEPV
SRVHALSHAIDKHQPMRGIELTHTATGKVFQVSTQPMAAAQHSLVQFDDVTDQREAEQRR
KLAELIFDKSQDATLVMSRDLTIKTQNAACIHTFGVHHSWHTMSTDASYRLSYAELKTLL
TTGNMEWHRMLSGHGGIDIPCQVVARTLTNHRGRVEGFVITIVDLSAEMEIKRLNYIANH
DALTGLANRAHALDKLTQDHDKERDMHVLFIDLDGFKSVNDQFGHQVGDELLKVVAERLK
SSVSRRDFVSRLSGDEFLIALYGNVPVDTVANRLLEKLSDEIVINNCKPKVSASIGVRYW
SANDPSSLAQVIEQADKAMYDAKANGKNRFSMSEKNAITTKLV
>A0A128FC24|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MTVTSIDVLDSVVDITAQTESDTISESLITTVLQLTPANQVLVLDYNAEASPEFMVVACS
DIFLFEEEKDAIERVLRNCVITGENVVEFSKDDNQSLLAVPIRYGENNEIHAVVFCKADE
LKGDEVQLIEGLARIYENYQKIISASERDGLTGLYNRKVLTTKIDLLLDRFLIQGTSITD
DPTHHHWVCIFDIDHFKQINDALGHVFGDEVILLITAMMKQSFDDEDILFRYGGDEFVVI
MHPQPREEMEKTVRDFLVTVNQRDYGQAKDVSISMGAASINDQELNAITVLGFADQALYK
AKQKGRNQVAFYEDLIASGELQSLVPEDDVELF
>A0A679JUL5|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MVLPRRFARRFRSARTWILFGILAPVGMLVVSALMLLDLRKDAWDKAEQTSQNLLQIIER
DIARNIEIIDLSLQGVTENLKLPALADLSPELRQLILFDRAISAQDMGVILVLDERGDSI
LDGHAIPARHTNNVDRDYFKAHKAQSGGGLLISQPLMSRLTGARVMVLSRRVDKPDGSFG
GVVLGTLKLSYFTRLFDRLGLGRDGAINLYLHDGTRVMRYPNRDSDFGTSLAGTANFERF
VREGSGSFVGTSSLDGVDRHYAFTQVGTLPLILNVALAVNEIEAEWRAKAIVITAIVVAL
CGLTVCLSLLFGRELERRGAMQVELARQSLTDALTGLPNRRRFEEALTALRGDAGHAARP
FALLVIDADHFKRFNDRHGHAVGDEVLRGLARCLLESIHRPVDLVCRVGGEEFAILLQDG
DEDEALRIAERVHARVALLAVEAAGIEPGSVTVSIGVATMGAPGADLLTPSDLFSLADAA
LYEAKANGRNQTRFVERRRGVVDRRQASFRLAGA
>A0A679JKS3|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MTLDLNTLHFASAASRCAYVVVFLVVALSQRRQTYLWQWMGAMGTSMAGSLIMMSVPPDA
LPSIPVTMVTYWLYSASLVLSWTGLRTFFGRPVKVGLSACLIAFPGVLYPLLLGAGLTVR
LSLAAIFACCLVMVLLATCETVRASAVVERLWSQYIVSVAFGSYALSFLLSIGMLVGTDL
PIASAESARISMIIDQVLGVFVYFGYVAMTAERANQVLLRLAETDPLTGLSNRRGLQTML
GHSSPLSNGHSAGGVLILDIDHFKSINDRCGHACGDLVLSAFAARIKAALRPKDVVARWG
GEEFIVVLPGADPQELREVAERLRATVADQPFSLPTEALMVTVSIGAALTGPTGASFEDA
TQHADAALYEAKAKGRNRVCLGPITASPSGAQVQAVDVPLGEFRLARLN
>A0A8F8F4C7|diguanylate cyclase|EC 2.7.7.65|Providencia sp. R33|TrEMBL
MAILLLAIPMLLTNIWFYVYVKNNTEKDIHDTFTLLVHNASIQSTTQQISDIKNNIVTMS
SFANQKEMSNFVLKDSGDLKKLISYTLNSSRFISNILFMDKSEKFNSIPEIPNEDFRPHT
RPWFKNDTNKNNLITFTYPYLDILTDKPIISASKNLYDTNGNNYGLVSMDLDLYEMSKPL
NQIKVPLNGELYIAHKDGRIIMSANKQQIYSEISNLKWLDNINSVQNYFYDPLTKSYIYY
YVFTDPDWIMLLVVKNEQFQNLIDDNRHSFIIIGIISFILYIAVSMLWNANFQRMMSELL
SSIKNGYEKKETNYSKEMLNIYDEIYKQHQEKSIAAKAAQEDELTGLYNRRAFNYCLKSL
IESKTAFSIGMIDIDDFKGINDQYGHAIGDLVLQGVCDKGKKYAGKNNLLFRYGGEEIIV
IFLSLTNDEALQCINAWRKSVQKMNWSNISELKVTFSGGFLTWSGQTESEILSQVDMLLY
KAKSSGKNNIVSL
>A0A2U3LBM1|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MVKLRQNVPNWDISQLFQELFLETNDILWLLDGHQGMLYLSRRFYVMSGHEQKHGQAIRL
VEDYYPMIHSVDRKHVAERIQEFVQCVSPKLAVEFRMLSRKGDILYLMMKGQRTEGTTNW
TSDDKHCLYSGTLSEISELKQKDSKLNRLTYFDSLTQMPNRSMFNYRTKLAIQQRIGGEG
SCAVVYLDLDNFQRINDLYGQHFGDNVLQVAGKTIAKSLEQEALVGRPGSDEFLILFSKI
EGQQALLEKLMLLRQLVAKPMTVQGRVIKLACSTGVAIYPEDGLKCTL
>A0A5B0K3A3|diguanylate cyclase|EC 2.7.7.65|Pseudocitrobacter sp. 73|TrEMBL
MNRKLKEIDELLSGLNRSVGGHYRWLVQAFRLIAKRNDGTDGITGLEAHNCCQFGGWLSQ
YLATNTEDKGFLLTINDKHIRVHEVCRRLVDSVLQDNIRETLFNDFEHALQEFVAAITVY
QTHLLQLRISYDALTSLPLRRILDESFESQIMDRSNGELYVMILDIDHFKRINDTYGHII
GDEVLRAFAQKLQSCTRHYEPVYRFGGEEFIVILKAKGEAEAMAAGLRITRAIEHHQIRV
GQYDIPVTVTSGLTRAIPGELLRIVLERADGAMYVGKQSGRNRCMYISEEGSIERVVE
>A0A375IJ83|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLANLLDRLWEQAVRTPQRFVVLSFAVAAMLLVLFFGYGLALLRDHQIQSLQQDQQL
QVAGISSVLNVEAERVMSVRAYAQHLIRLQSGPHAIAPDPPLKAAFDHRNDAVWTMPAPE
GDAVLVGVSPATLANLDGFSRRDADLLPGLYVARGLSHLISAEPVNPLVARKLLYVSTNG
FFVAYPPVPPAEAAATLRHIAAAGYLREHQPQDNPGQPMRWHFAPAADGTPDGYLSLSVP
VYLDRQFRGVAITEIPQHSLDAYLTRTTRPDVQRFLVDADGNLVGASTRDVRRGETLSAV
LPASWHEATAQEMFRRGSGTLRAADGSRILFQRIGNSSLALVDYFSATDLLLRVASHLSA
VLGASTLALALLMWVTLQGIGKLFSHYQARGEALRELAGTDTLTGLANRREFKARFDIEY
QHRRREQTPMSLLMIDIDRFKRINDHWGHASGDRVLTALAGVMRATVRAIDLPARVGGEE
FAVLLPRTALDEAVRIAERLRRIIGQTTCAPAADAADQAEIRFTVSIGVSDMGGDANDRH
HDAGCGSQAVRGQGGGPRPGGQR
>A0A6N3R3J2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTI
FKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFR
YGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYE
RLIQIADEALYIAKRRGRNRVELWKASL
>A0A6N3R2X9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINM
DMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGV
PLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSN
IGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVF
IDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESAR
FIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRG
RVTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWS
CEGEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSAT
LVNDLLEQLGNSPLPPRLLHLIIPAEAILDHAESVQKLRLVGCRIVLSQVGRDLQIFNSL
KANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIG
VDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A518F051|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Poly30|TrEMBL
MRARAAFSEGNHMHRSLGSRLRGKYRLVDPGELHRMRDSRAEERLRTLREVVDVMDEPAF
VLRSDGVVMAANESLARLIDKDIAELSREHLDLVLGLNVNDSYRVIAALFRKDSHGPVHL
NAEESPTGAVLELDASPMTLRKYDRAQFAFVRVRPDGNLADRLREMTSRLASKTLSADAI
QADSHALERDIAALERLAHKDPLTGLENRGAFDKHLARVLGQALRDGDSAALIILDVDNF
KVLNDTWGHDRGDECLRQLAKVLSSAARRPLDLVARVGGEEFAVILADCSLHNALAAASR
IRRSIHAAALDHPYGRVTASIGVAATTPADRKDTTELYRAADRGLYEAKRSGKDRVCAGF
LEDDKGESQTAG
>A0A3S4GZM5|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MHTTQSPDTTKLQPALTVFILVFAACIFGIESRPIGFLAAFWPSNAVLLAVFVRYPGLVS
RLGWVMAMLGYLTADLITGSALDKALLLNGANIAGVAAGYQLFKRVPQQVRTLERTSSSV
YLFAISLVSAAATGVIGALASVLLFDREYFPALALWMSSEFTNYITLMPFILAFPTDWRA
YLRGIAQGITRRQAWYNTGKKLAVLILLVLACVGSILIGGPGAVIFPMPILLWLAMSFSL
FTTLVVVLIYVLWCHLAIDLGLIAINVDMKALQNTVSMRLGVALLALGPIAIASMNFARN
ALLRQLEHVANHDALTHVLTRNAFMQRGSRLLSQKGEQVCVMMLDIDYFKSINDRFGHSG
GDAALISFTRAITGDLRDSDLFGRMGGEEFAIVALIERQQDATYLAERLRRRVEIESIAM
PAGNHLQITVSIGMVTCIGGTEQNLDNLLKIADMAVYKAKNSGRNRVATPEISPLIDNDR
>A0A1X1DAH2|diguanylate cyclase|EC 2.7.7.65|Pantoea wallisii|TrEMBL
MPITLPPQRRINPYARVHLCFLAVFLFSAFLTAHEALELKNNYEQRQSAQLAEIQKALDS
QFQESVDELNYYQKMLNYALTHPLDADYGREALRRFQLLRHQPTWQLQLPNARSMPLNGV
GDSWLARDPLLVRNPATLEAELRAALEFSFIMQFGNQTQDFHSRFWYTSRAGYFISSRPP
ENAQALEQSYATMIQRGYFRDQNPAGAQHAQRRWTGAYQGEFGEGLMLTVSSPVVSQHYW
YGVLSMDFTRQRMHSVLQSARHSLLQGKLLLVDHNLQEITRLSAPDDRPLTSQQQARLEQ
RMRQQTTGVLRLGTQFASWSKLNNVDAWLVNIQSLQQGLSQELGRLALFLFGMWLLFVLL
LLLAHQIIFRLVRRMDALSARLSWRANYDGLTRLLNRSAFFEQFVALAARCQQQQQPLAV
IQLDIDHFKQVNDRWGHQAGDQALMHVAAVISHTLRRYDVAGRIGGEEFCIVLPETTLSD
AQAVAERIRIRLAGKTILLNATTVFNVTLSAGVTSSEEQGDYNAERLQAVADRRLYQAKS
GGRNRVCAED
>A0A833UPN2|diguanylate cyclase|EC 2.7.7.65|Burkholderia gladioli|TrEMBL
MRAFRSASIGRRLWWRAILAILLVAALAILALGQVYEAFSQARHHARLLRELRVLLDVAN
DISSERAPSNVVMTASGHASSAAVDWLARGRAKTDRDLDAASARYLSSSQAALVKRRLAE
ARRLVDLRALQVDPPGVDVQDSIDAMFAAYDAMHDVVAAHAANTIASTPSLQGAVLQAMA
LAEVRDAAGRLGSCLVASMATHTPLSERNLENIDRLSERIRAFWWQSGLDERSAEIARRR
AEAWGAFARDGLPLIDSLTHAGRRARLDTMTVADFTARYVQALRPLEDMRRHYLETLVDA
YVEQERYRLVLLVVAALLALVVVALVAGLMSIMHFRVLRPLLEVSEAVITLADETRMPKG
LRRNSARELHVLFDAFDILESRMRERASLAEKLKRQAQTDALTKLFNRRAFETFGQIKLR
GADPAGQPFLILLDLDHFKSINDRFGHPVGDGVLVKVADALASQVRPGDLVARFGGEEFV
VLLHAVDVAAALSLAERLLAAIRAVAVFAADGTAVPVTASLGVASGSQLSLRQLLSHADL
ALYEAKRLGRDRIRMFGLAAPA
>A0A1V6HF49|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MIRTVPKPDDLTKLLLENLSDGVYYVDKDRNITYWNATAEKITGYRKGELLGCSCADNIL
RHMDVSGQELCEIGCPLLRTLQDGEKREAFVFLHHKEGHRVPVHVRVAPLVGETGEIIGA
VETFTESAAGLDMQQEIERLKNDAYRDPLLGIGNRRLAELMFQNFAGQRDVIGMIFFDVD
SFKEINDELGHAIGDRVLTMISRSVSSALRQSDLFFRWGGDEFMILLPNVSRSDLRAIAE
RVNVFVERSFLMVDGRKISTTISTSATFAATSESLELAVERCDHLMYQSKKDGGNRVSVG
>A0A5C6BRJ3|diguanylate cyclase|EC 2.7.7.65|Symmachiella macrocystis|TrEMBL
MTNVTEVPAPSNSNSQQYLTDSSQVLLGLLTLSDNCVAHPRTTDDDTGDVIARPALTSLL
SALHYRDVATVEHARRVAMLSLGMASQIGWEDRELKILEVAALLHDIGKIGVPDSILFKP
SSLSPEEAELMSLHYYIANDVLQAYHVDPEVLEIVSQCHEHYDRVGYDSQRVGSDVHMGA
RILAVADAYDSLATEQVYRKAKPHDEIMQILMLGAGTQFDGNIICSLSRWVEDGRVPTGM
HLNSKGLLPSEVSDREFRGDSENAGALCHIFAYLHLLENLYDGFYLMNSDQRFVVWNRRA
EDLLGHRPHHMLNNVWSNKTLGYCNDKGKPLADKKCPLFQALAERKPVTTTLPVRHRSGE
LVEVEVQTVPLIDSDGVLKGVAEIFRNTSRQGGKTKQYRELKEAASRDSLTQTANRGEME
RQLEQTLAEATNSQTAETFCVIFIDADHFKSINDDFGHTVGDDVLVEFAKLLQNETYSGE
LVARYGGEEFVVICPATDLDQGYKRAERLRIAVSKLKIADLKGRKLTASLGIAVNEPGDT
VTDLLSRADKALYEAKGAGRNTTRAYANKELDIKCQVENAQKEAKEAEAFMYKGTFHAVI
ASDMLVYKLAGFVDDYQSKIMEVTPERVVMRLGNRGVIPGWGNHDGRRPVTIEVVIGKEE
VPEPGKARARAKRVEILVTISPVGWIRKKDVFQHRAAGVFKDLKSYFIADMDLTP
>A0A1H6FAG9|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MAKALYFIFLFSLFFSASLGAQVSASSAEQKHLTFGVLESPPLVQRTPEDFLQGFYIDLL
REYAKLHNHSIDFAVTRSTSMLEKLETGQFDLLIGFNPEQYPQAQWIFSKESLVTHWAEV
FTHISRSGKIYSLPDLDKRSIGLVQQTNASTNLKNLCNSFQIRCNIKQYPSNEALLKALE
QGIVAAIVLDTLEAQTYQNQQILHSTGIVFAPRNKYLMGLKGRSEALLQNLDIQLAAWKT
QADSHYETARQTWLQTPQAAPVSPLSATPLSAIKQPLLTDRVRWGLMIAGFFILLGTLLL
WRNSKQGMRMLRLERDVLQRNESRFRNLLENIPYGLQDIDLNGQILFANSSYYKQITIFE
AIKEAEEQRRVQQYLKVLSIEQPEHPDPIYTTLKCRRKSGCAVRMEWSYKYDEQDQLTGF
FVLVTDVTGVGETKKRIRDYHIQLKKVADERKADLMDAYNDLLITAAVFENTSEAIMVID
LEACLTSINPAFESMTGFNKEQTLGQPLSMMASKKHDASIYPRLWEKLLNQQCWQGEVWN
QRANGSIYPGWLSINVVLNSDEEVTQYVALLSDITKRKQYEKQIWRQANYDALTQLPNRN
LFHRRLEQAISRVRQDKHQAALMFIDLDHFKEVNDTLGHDAGDELLKAATRRIVDAVRKN
DTVARMGGDEFTVILPIVEKPDIAVQIAKKILEGLNQSFTLNQGEVNISGSIGIVICPKD
GEDLTTLLKNADIAMYKIKEHGRNGYYLYQKES
>A0A8I1MAJ0|diguanylate cyclase|EC 2.7.7.65|Thalassospira povalilytica|TrEMBL
MNDTSQPASNATRSAKGNSKGHKMPESVAEGGMADAERDILAELEKALGEHIALILRWNR
KLMFPDSPHPSEMDDDEHDCDFGAWYELNRNNRLIDQPAMHALAATHQQLHDSAKRLLSA
RAVDGVIDSAEFDMMALRAESFFAQLRRLERAFRTARSDVDPLTGTYNRQTMMGDLNSER
ERAIRTQVPTAIALVDLDHFKSVNDTYGHQAGDLVLQSVAGILQSHVRPFDKVYRYGGEE
FLICLPNADMKQCARVLERLRRVIEASPVAISDSTTLPVTASIGAAPMTKSRTIEQIIEK
ADRALYAAKEGGRNRVRVWRSPDTKPAPKPSK
>A0A377KS78|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MLERGVLLAFGLPLMIASLLVTADVFVRSVQKISVSRPFKYFIIGILTFTHLYFILSFSM
NSVGFICYQYTTAFIASHFFYGDRGKILILITPCMVVFYLLFVGFSDIGKAFYLPLLGVG
VFVLDFLLSKIKPLRPQQQFYLMYFLTCLLSPRFSMLVHHTTTYDWEAMLAVLVGSFVLL
GGFMWLHRLIEGEEYQVLAELANSKIDALTGCFNYGTYNHDLLQAVSQKKTVTIAMIDLD
HFKKVNDRYGHIAGNELLRTFATRTTTFLEAHFAETFSFYRYGGEEFCVVIEGDVKEKTV
AAMTTLCQTISSSMFPVANFEKGTMSLSCGVEASTVCHGDILAAVERADQALYLAKQSGR
NRVCTLPET
>A0A4V0AP82|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MTKVKNIRSLNEDVDSMTDVEKEKLIFIMMDLDHFKRINDHYGHITGNRALIFFSKKITT
FLSEAHQDQVEVYRYGGEEFLVIFKDSTLKSVQKTILRFQAFLLKNKLNIGGERKITLYF
SAGISKYDSSLDVYELINQADQALYAAKKKR
>A0A0P0EVI5|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALAEAEAISGVFYTILLDRPDSNAFL
SHTLVQERLRPSLARWIAALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDNGHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTNRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEASLRVKADQLRRTVEEHRFNGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A7C1XQ62|diguanylate cyclase|EC 2.7.7.65|Rhodospirillales bacterium|TrEMBL
MNKNNTFPSLSTEEAEKIVQELGNALDVQRNWTRKFQAMLVCRTKPRATDLNENTHRKTV
FGRWYYGNVNPLLRNHSDFTAVGGNSERMHDLARGLATAVSDGADVTPAQYKAFMNSVSR
FRVSVRKLLSEAWESLRYTDPLTGVMMRTIMHRRLEEEQERVRRSGQPCSIALMDLDHFK
RVNDAHGHQAGDQVLQSIAAYILGHMRRYDQIFRYGGEEFLLLFPNSATSNAKGVLDRLR
RGVKRHKIDIGKSKKMSVSASFGLAELHPDHPVRDSIKCADQALYEAKNAGRNRVRVWRR
EN
>A0A8J7R1S0|diguanylate cyclase|EC 2.7.7.65|Tianweitania sediminis|TrEMBL
MLNITFLLGIVNSLGIFALVTMGYGILLKRIHNRFVLSVVLGVVFGTAGCLALANAFKIL
PGVLVDVRGVMLVLAAPFGGTLAALVAGALVSLARLYAGGVGAWAGVCNVAATVLIGLAF
TNLIFHQKRPGSLRQFAALGLASNLPLLFILTIPVEDPLGAFLRAVGPLMVAQTIGILVL
GRFLCRERQAFVARQRLEAEASTDPLTNLMNRRRFDALFNAKLAEARQACSATSMLVIDI
DHFKRFNDRFGHDVGDMILVRVAQAIDEQTRSGDLIARFGGEEIVVGLPQTGLSEAAVLA
ERIRAYVADSVFYGDTESGRVTVSIGVAMHQGSGITMQRLFKAADEALYQAKGRGRNRVE
LSPPRNFEEEAASNRRRYADGKSPQEPNWNPRRARASAKGR
>A0A3N4NWS5|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. RIT388|TrEMBL
MSVELLSSPDRPQNRLLNALILGVVAFLLTLFCLELIVVSGRISPLWFATALMTIVVFRS
PPRDAPLLLLGCLVGTVLANALILGPQLANLKFSLINLTQALIGGALLRMLLKPQAPLNS
LLDWLRFVLSVGIVTPLLGSMLALWAFHVGSESTLSFFYTWVISEIIGMLALGPVLLLLP
WPLRPPALSLRRLATFLFSLLLTFGASWLALRFMPWPFTFIVVLLFWCAVRLPKRDAFLL
FLLNACFISLLLALSLVTLEQRDYSPGQIASWLPFLLVLIPGHVMALVMDALQREKHHIS
ESETRFRHAMEYSAIGMALVSPEGAWLQVNDSLCQTLGFPAAELKKLTFQQITHPDDLES
DLQHADKLLRGESQAYTIEKRYFRKSGEIVWARLTVSLVRDGERRPLYFIAQIIDISELK
QSEQVNRHLMERITLANEAGEIGVYEWNLMSNEMMWDRRMYALFGLSAHEQPSRERWRSL
VHPADRDRLDQALLRSTEKPGAVDMEYRILHPDGVRTLRTQARRFFSPDGRIERMLGICQ
DVTHLRNLTDALFQEKERMAITLDSIGEAVISTDSDMRVIFMNPVAEQMSGWQQEAAAGK
PLSELLHITQGRHGPPIENLLLCRLPTEKTIPDLDDELVLHAADGREVEIHYSITPLRTL
EGDKIGAVMVIQDVSESRKMIKRLSYSALHDALTRLPNRASFERQLQRLLDDEEQRDRQH
VLVFIDLDKFKAVNDTAGHAAGDALLRELADLMQRHLRSSDFLARLGGDEFALLMPGCAM
AQASDVVQRLVQAVNSYPFRWQGGTYQVGASAGLTQITAANAVASDLLSQADIACYHAKN
SGRGRLAVYPPQRS
>A0A3S4GJD7|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MRVGRLRVMQVKWPSRYVLRKTALVSVIAAAISISLSTGVRAVLGIEADTVTVLVRLILP
FAIAIPIALVGFSKLEETLNAYRDLMRKSSELARRAATDPLTGLLNRRSFIEQFDLTMAH
GVGGLFVLADADRLKAINDQYGHLAGDDAIIALGKALETVMGADCLIARIGGDEFCAFVP
NRTATLNDAQLAEINRLATEGFATRSGNDRQPVSATCGSVVLRPPTTFREAIERTDRRLY
GEKQARSSSGAVQFA
>A0A3S4CR42|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MDHFAFLLPSTMILFAITFLAVGWSGPKSARAWGLAFLFGALGFIAPILPLPFALQSLLA
NAAFLVSFYCYGDALLLHFRAPRMIAPRIIFALLAYAMVIVAVEGFASLPLELTVADISV
AILLGVPLASVIWRAHTLPDRVLVAVAGIVVLDIIVRLFIFNVLVGISPALSDFAASSYA
YYNQVAVGVLSVGFALAAMGSIVSQMLAGYRSAAERDPLTGLLNRRGFDAVAAPMTPMGQ
GAAILLVDVDRFKLINDDFGHEAGDLVLAGLADILRSILPGTAVISRFGGEEFAVLIPRL
SMAEAGALAHGIRLACSERDWRLCGVDRLVTLCVGVSLVLSEEPNWKAAFKRADSALYAA
KDDGRDRVMFAKPDAYLAIERAA
>A0A1A8T5S1|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MSLFSEYLQKLALIGSRNSADVDHNRKQVVNITYLLSMLVGTVSAMIFTAQGWLVESLLH
WAGAGVSCIGFLLSIKGHSRSARVLFPFACALYVSLCTFLFYGSDSHFPWLLIILAAYSV
AGFRVESGKEQLSVCWFALLVFAFNKLFAPLTTGYASKDVQLFVSLATFIAAMIMIVLIT
GVVVNKLRKLNEHLRYHAEVDDLTKVSNRRKVLAEAVNVFADAVISNQRCCFAILDLDHF
KQINDCFGHEVGDRVLQRCAQTMQNAARRGDWVGRYGGEEFVMVLPNTRLQEAFEIMESL
RVQIGDLRIYLDDQDAPIAVTTSVGVAEIKDNTLRYEQILARADAALYLAKKNGRNRVEM
DLSE
>A0A1A8TEX7|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MPSLLKHYRRSIALHLLLVIFGIYFLVAVLVTVIQLYKEYENTKKEFYNEIQTLPSTFGK
GISDSVWTYNQELLQSILQGMYNLPIVVGVKVSSLDQKMDFQIGAVLNEQHQFEYYDSKG
RPTEQTLTGLGSQALFDHEFPIYYQGPAFDQKIPLGTVTLYSNDQLVFERLKYGFILILV
NSIIKTCMLWFIIYFFINKYLGKPLKEFTFKIHQQDTHSPKPIDLAINWTDKNELLVLKD
SYNQMIQRVNNNQLELLKLNQELDEKVKARTQDLELAKENAELLAYSDPLTKLNNRRAFF
DSGKQSLNQADTQKHSLSLIMIDLDNFKKLNDTYGHAMGDKVLIAFADMLKSSLSSTDII
GRLGGEEFAVILPNTGEEKALQIAEMLSQKASQIELIHEQSLVHFTASMGVVVNPQGNAT
IDSLLAQADKALYFSKRQGRNQVTAYSSVVTTT
>A0A1A8TLT5|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MAVVLGLSSVFALLGLKRPQLSRYILLMLVVLVCFSAMLIKGNQGYNLAWAFICPPLSIF
LLGYRRGAVISGLYLAMVVGLMVAQGDSWQATQWHGGALANIIMIYLGLFAFACHYEASR
RSSHEHLREANAKLALLAIQDDLTGLYNRRYIEDLLLNSEQESIFVAMVDIDDFKSINDR
YGHPVGDEVLKQTAHILQDVVAEEGIVGRWGGEEFIIVHYADQPSVFVNLLEALVQQVRQ
RSNQYGPSVTISVGGSTYYKQFHKASLHHVDHALYDAKESGKNDYRIVRHAYHGDLLL
>A0A0N8Q4V4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MLFRLILLFTVVLLSTLKPTYASLDDYVVKQWHIQHGLASQSLKNIVQDQQGYLWIGSQF
GLSRFDGNRFTNFNVNNSDFLPSNAINSLLIDNDGFLWIGTDNGLVKFSPSELTSERFSL
NGPVRDIAQDNNGRIWIASNSLYLYSNQKLNTISQLLGVSDTNNNFSNKRNALVKLIGEV
RKMALSPDGIWLINDRFLLHLQSLANETTGKIRFEITERISLPQRLAQSVLYDLAWLEGD
LFIASEVGAYFLDIDQELRPFSLPYANNATVYKFMYDSDGSLWVSTKGRLLYRDSSGIWQ
WIEQSDLEQTVWFSDIFRGQDDIIWLASLTEGLWQARPSQVKRHRDSKGLNQSVTTLKYG
EDQRLWLATKNGIGYLDESGLFNVEIAAAKLGGLTVHDLHFQGSRLFIATNRGAFVYDGK
ELLKLDAATLRATAVFAIESAEQGGVWLATDRGLYRLAFNGLRSFVYNSFLDSKYITFID
EQNGKGYLGTSRGAYFFSERGIERLAMGSALAESNISFILPVENRLFVATQNNGLFYRSE
KGVWRQLDVSNGLPYGPILSLHFDQALNYLWVSTSKGVYRLPLKQFEEGIHSLEVEQVIS
PYNKQLDGKTSQCCSGNALGAIARVGSSLWYPSKSGLVEIPTNIRLFSESDIRPIIETVT
ADNGGEKNTYSVPEVDTLTLQTEERNLTLGYTAINFQTASEIDFRYRLVGLDGVWREANN
SREANYANLPAGKFVFELQAKRRGQEWSSADTISQTLIIPKAFDETVVFRLIVVMSFILA
LYIVFLFYRNQERRKQEELERLVETRTQALISANEQLNKANDRLKLVSHSDELTGLRSRR
FLFDQLPKDIEHFQSNRESLEIQGKCMALLILNLDKFSRVNDVFGSFAGDNCLQQIASLL
TEQVQGADYVVRWSGDEFLILLRDMQKSAVHQFARSISHQLAGQNFVMPDGRKTKLTGSV
GWAFYPLPLLGGQIISWETSIKIADIALQKAKAKKPGSVAYFSFSDNIDAFEFEDSERVA
QQLESLLDSEQAKLHISEI
>A0A0P9HKT8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MKPTALSEPYSDKKEPLSKFKSLKLKTYLRLENNPLVELISSHSHSTDFTHKRSDYIRRR
LWIMCLFFAFSVPLFGFFDFLTLPQAHAQTLLVARISLSVALFIMAYRVKRSSSVSLIKH
VIALSFLCPSLFYLYIMLTFNSLDSVPLIFTMMPYLTLAMIGLFPLTIRGGVILISLIFI
PFMLVQAHFFNGDYWHLFNGVWLFGLFAGISLWLQIAQLSMLMNLYRESTVDPLTKLINR
RVMLRHIEQLKQQNIGFSVVMFDLDRFKRINDTYGHLAGDNVLKVASHIIKSKLTRHDIV
ARYGGEEFVAILPNTHTTQAISCAEQIALALKAEPIKMSDENSITITSSIGVTQYQHGEA
IEMMFKRVDDLLYDAKELGRDRVVSDIT
>A0A0P9K1U2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MNISYQEAVGVSSTIEIIACIFALFILRSVIKDNKETPYLFGYFISSLLFFYFLNKPPLH
IANTDWYLEDLIGTITSLLFGLTICKKSESDKLSLLLLVSFAVFTCSILFIENHVFYTML
FSAYCLCIALISLVKVKNPNQADKGLVIFLVISLLVIFYELSSIPKGISRREYFETDFYY
LLVYFSSLILVLTVFIFTSQLINLTLKYKALATQDALTGLYNRTAVYNLVNNQLALAKRN
KQTCSVLMLDIDHFKQVNDQHGHQQGDDAIKLVAEQIQHCTREYDISCRYGGEEFFIFLT
YSDENVGFQIAERIRKAVTEQSKDKLYGPLTISVGLTQFKETLSVDENIDIADKALYASK
QAGRNQTTLS
>U4K7G4|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo|TrEMBL
MPLPSRLQTPVLLTVAILFTLCAVVSVTQIVKSLDLLAVNEHSTGRAIVQLMLLHQEYMN
DAENYFRGLIEVDELLTSYDLTWSAFEILLVGSESANLMERQGRLEIIVDTFESFKELDP
TLDSFNEIHFSQYLAHGQQTSETINALLNEEFQRVSEKNYSRDLELVRLNSIMGYSYAGL
AICGSLLLYITLKDRRKISHLAYHDSLTGLANRAALQNQLIDLKRQNSAGFTVLLLDLDG
FKLVNDTYGHDVGDRLLKRISARLLKTCGEGDFIARLGGDEFAIIQHSQEEPQVLPEKII
ESLSKPIKVGSVDCKVGVSIGICLASEYQDTWVDILKAADIAMYQAKSNGGNSYDFFDDA
G
>A0A1C3IT24|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MALPKTLIRLFKPYIILLTGGMLYLAAAQLEKVETTAKEQSLSNIRIASSIINSNIEATF
GKLYFLETSLSLSTSGPVGEQKFRDISDNILKRTPNFSDIVQYQPQSQQYISTRGLPLSN
EQIDAIQWNPIDSVVEGFYISSIYQKPDGRWVFAIKHTTEQLNKEIWIEFDLLHTTQGLR
DLKTLDRGYVFVVDRATERLVFHPDPKRIGSKSISYHAGISHQLSQGETVGQHEYYYQDN
FKITVFDADNSLNWVFVSGTDRHDILTSSHQFTLTGVVLGSLLLLWIGAHYLAHRLNMSL
SQLNKVDDLASFKRELKAIFNSFTYQKGIQFCLYQAESHSFSTIDYHGNKSTVHSDKALA
ERFAPESMAYRSSKYADPLARKLKILQRHYCIPLHSRNQLIAVIYVNAPLPISQSILRMI
KDYTEVSLSNLLLHHQLSSKDLMTQLDNKSSFNIAIDNYACEPDTYVALLDIDNFDHVNR
AYGEAIGDKMIKLAAEAMRSYFPKPKGLCLARVGDKEFAVLFKANDAKDAKHQLEQCRVS
IAEKTIVTPDITLSLSISVGFSQIDGETDSALALAEQAKLIALQLGKNRVEGHIRGVAKA
S
>A0A3S4IVP3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sanjuan|TrEMBL
MVGIAIQHVIQKRYDNFAQQLMFKLLAERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAP
GSHEHYVLLLDIDHFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLL
TTAEPQQARATAERIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIGDAIEKADKA
LYEAKHLGRNHILVSDDMRAL
>A0A3S4FB63|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sanjuan|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPITAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQESVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A5K6CNW1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii (strain AB307-0294)|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKNQEELCANLNLIFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A0H3LKY9|diguanylate cyclase|EC 2.7.7.65|Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWAAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A241Q7J0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MKQENKHIAMAAAQEKIARLRQGFLRRIPDMLAQAERLLVQLVAEPSEACRKQLHILLHS
IHGSAGSFGFSPLANASAEGERLLTEPETEQSPLHYDELRRIIRWLYTLTQEQLNLEHRI
SDTDFTLPITAQRPEEGYVRRASKPIYLCDDDIDQVELLATQLRCFGFTCHVFSSTQDFT
QAVLSQPPAVVIMDVSFPDNAYGGPLTMSDLKQKVGKAFPVLFLSCHSDFNARINAIKSG
CDGYYVKPASITDLVQELHRLTQPSLKKPYQVLLIDDEPAVAEYNAEMLRMAGMEVHVLE
KPHYLLHVLNAQPIDLVLMDYHMPEFSGEELTKLIRQIPQHIGLPIAYLSSETNKHAQLG
AMSIGAEDFILKQADPEELIRAVTIRAERMRVLRARMSQDSLSGLYNHSTTTHFLKSAIA
ESNYSGNQFCMVMVDLDRFKSINDTYGHAVGDQVIVGISQLFSHRLRSTDIVGRYGGEEF
VIIMPNTSSEKAARVVERLRKDYEQVAFSVNDASFHSTFSAGIAQWQFGDRIETLRERAD
QALYAAKQNGRNTFCIAE
>A0A8D4LYQ9|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFAYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLMWMLLPKETTLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKNISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSVAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSLLPPRLLHLTVPSSVIKTSPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A381GPM8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFYHAGHVSPVITQEHLHLMSDMILARVSQSLATEQSVESLVRQLLEMLEMVTEMESTYL
TKVDLDARLQHILYARNSKQMQIPEGLSVPWDETLCKRAIDENCLYSDNVPARWPECTAA
RALEITTFLSTPVHLPDGTFYGTLCATSRHQHALSPRGEQVLHLFAGLIAQSIQKESLVA
QLREANAALIAHSYTDALTGLPNRRAIFENVETLFSLARHLRQKIIFAYIDLDDFKLIND
RFGHKVGDQFLIQIGQRLLRECG
>A0A7D6XX88|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLCKDLLSVIVEERSQSWHFDSFQDALLAFRSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQACLAGLRLCHLIEQKKIPY
PQGELGITVTAGLTRVHQGETLDTALGRADRAMYAGKQTGRNRCMFMDKHEQVRRVGAND
RITTQV
>A0A336QPI7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRMLKTKADSTPALLSDTICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPYGEMVFLANSDFGMWLSHKGKHILGNSNLL
NEMESLIAEIDNRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAIIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>I4F584|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MLLDHDDDAQTAPRLLPGWWWRGGDAVGYGRLLGLGSLLISGLALLLLHPAQVHWDQLGV
LAGFHLVAVWLSFALPWRRWSPWALVAFPVTSMAALVLVTDAAPGLAGVTVAYFVLCFAY
TGLFLPAHGSWVLLVPAVATYFGTLRAVTPELAVRTVFVAAAWVVLAGLLNRLQTRQLAL
IGQLRADNLTDPLTGLANRRGMEVFLAEAEPGDVLIVFDLDNFKRLNDEHGHAAGDVVLQ
TFGRVLTQQLRTRDRAARSGGEEVVVLLRCGESRCGQTVTHRFREALALACPGVTFSAGM
ALVTADRPVQEVLEAADRAMYSAKHAGRDQVWVSTGDDRPDYCVHRHAEYTPEATPVGV
>A0A844CS51|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT693|TrEMBL
MNKDLTMPSRPTFKGTLRRISIISVVIAMLIVWLLLSVASMLTLRQYAQKNLELLAVTVS
HSLEAAVVFRDGAAANETLAILGKQGQFTAAKVVDANGKELTHWQADKPAQRDMVGGLVT
QWLYPHPIRQPIWHNGKIIGEMRLIGTDATVTLFVWLSLGVLTACILLASVIALGISRHL
HQDIDAALQNITDVVHDVRSNRNFSRRVSPEKIEEFHLFALDFNSLLDEMEEWQSQLQLK
NASLQKTALQDSLTGLANRAAFRCALDKLIEDADTLKDSALLFMDGDNFKFVNDTWGHAA
GDAVLIEVAKRLLAFANTRHLAFRLGGDEFAMLLHSVNSDNEATLVLKQLKEIIEQPILL
PGGHWVTMTLSVGVALAKDITSAENLMETADRNMYIEKHKQRELLTKQHQRNSL
>A0A378IJG7|diguanylate cyclase|EC 2.7.7.65|Legionella cincinnatiensis|TrEMBL
MQIDFLNREELQEFIFQFEQALYNHQQWYNSIIRSLVCRLPSDQHDVSVNAHKECRFGQW
YYGPNSHKLKQHAAFIALGEEHHYMHKAATTLLVAIDNDNKISPHDYDIFSNSIEKLHLE
ISALQRELNELLYSRDSLTGTINRNNMLPILREQQELVKRQVQLCCIAMLDLDKFKNLND
QHGHLAGDCVLATVSRFIIENMRPYDKVFRVGGDEFLLCLQNTSTVLALEILERIRSGIA
KMAIHINNNESVHTTVSMGLTSLKANISIEQAIEQADQALYKAKNEGRNCIRII
>A0A514ERA7|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MSSLSIRSFTLFREEHPVRDALVLFTLTLLLHFFGAMLRLVQELSFFWPLNAVMVGIFVR
YVWLNRSYFYVTCFVAMMVYDGLTSRWGMGFASLLINFSNMVFIVSLAQLLLWDKRRTDS
MPGPINVLNLFCYCLLAAFLSAAVGTLGSMDVERETFLSLLGDWFSEQFSTAVLILPFIL
TVTIPSTLSGFRWRQLLPVLVLVLSIILGVAVGGAETITFPLPALIWCAIRYPLPLTCLL
TFLTGIGEILLVANALVHLSPDAHLQPWQLFSTRLGIAAMLISPVIVASSVDAINNLVKQ
LALRADFDFQTRVYSRSGLSEALKRQPQSATQQLTVMLLDIDGFKRVNDSWGHECGDCVL
TQFAQRVRDLVGEQGLVARVGGEEFAVAMLSATPREGELLAEKIRQGVAAQTFVWGPHKI
KLTLSLGLECRPLSNGRITELFNQLLMAADDYLINAKKAGRNRICTPTLAENR
>A0A239SL86|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MALGLSLPALDLPTLQFVTFLLSIATGILFMLDALRRDEAESPRWWSLAFLLATFSPVLY
LLASRSAQLAVLYPLGNAVATLAFAMVWSGARRFYGQSVQWVAVFGGPAVLLWGTWLFAR
PLDAWSGGVLFFSLLALYSLMAAREFWQASGLRLPSSIVLAVVAVLHGSFYTARAVALVW
LGPTDSQFLAWFGPQVSTTEMLVLIVVASFLMVSLGKERSEIALHRAATRDGLTQAFNRP
EFTRLAREQLRRHGAARAPVALLLLDLDHFKRINDTYGHPFGDTVLLLFARTASQQLRAD
DIFGRYGGEEFALFLPGVGANEAQTIAERVREAFERSARTVQGEAVAATVSIGIACDERS
RGELSSLVQRADRALYQAKAAGRNRCVRYTPETAMPVVDPSAHRADRGDRVEPAEVATPS
LQAAAGS
>A0A2H6IEQ3|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin07|TrEMBL
MDALVLLGIVLLTSLPVSLYLYKLKNRMRDYNKSFNKLQTQAKELADNAPSFNDDTLMSR
YLTDVLEVEDDILGLLRIAERAMVADAVSLFINEDSGLVCRLSSGRSGIVTTGDGLIYTV
FRSGKTLLHYAESPGKDIRPGYLSDAEISTLLAVPVMELTTSLGVLCADSMRYRAFDQQD
IGLMELVAREIAKILKRQRVYSQIQLSYRSLRILHEESAPLARSLELSALCERIVESAVR
VSGGKVVLLLKKGRSYELFTKGAGYLNEKKVTSLKGTLLEMVHANRDPLYHPDVSGFRTR
VLPFHFRGVKSVLALPLFHEAKVKGILTVFSEKKNAFNSMQINLLEILVNQASVSISNVL
LHEEIKKMAFTDGLTGLFNHRHFKEKLTEEFRRSERFEDTLSLILTDIDHFKKVNDTYGH
PVGDIVLKGVAGIISRTVRDIDIPARYGGEEFAILVVKTDAKGAKKIAERVRKNIKAHDF
KVEGHLLKVTVSIGIASYPADVTSGDELVEKADQALYGAKKGGRDRTVLYGDLK
>A0A6I6E9Y0|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J780|TrEMBL
MDKPSADYSRPSFRKALVRISVISVVTTMTVAWLFISATSMLSFRQYADKNLQLMAHTVS
YSLEAAVVFRDGNAAMETLKELGKQGQFSSAVVTDIRGNELVRWGQDDDSLLHKDPLGGM
VSGWLFPQPVEQPILHNGERIGTVTLIGEDATVTDFVYRSLGVLTICLLLASLVALLFTR
HLLRRLIAALKNITGVVHDIRATRDFSRRVPPSQINELHLFGEDFNSLLTEIEKWQQREQ
QERASLLKRALHDPLTGLANRAAFRSALESVLSDSTRKTHTALLFMDGDNFKEINDTWGH
AAGDEVLLAIAGRLSDCAGNTHLVCRFGGDEFAMILENISHDDEIQAVIDDINRRMAEPI
HLQGGERVVMTLSIGRAIVSQAATVEGVMEAADRSMYLEKQQHHQRAVS
>A0A8F7LHL8|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MSICVQLRSLKLRLLLPYATLILLLTCAIGSLTYWAGARTVTGLSDQLLKEMASRMHQSI
EHHVSGSAAVLEAAFPTGMAAGADIRHDWKALRARLWAATTLAPRTNDYVYYGNIAGQGV
GLKRHPDGTAELSVRTDANQHRRYYRLDRIDDPAHYLRTEAVMFDPRQRPWFQLASRVDQ
HMWTSVYIDFGIKDLVLTRARRVLNTQGQFEGVVATDVSLRALNDVVNDLGRSIHGLAFV
VEPDGQLIAVSGMDNVRFADGGRIERLTATTSGNPLVHSIYLQVRSHFNATVARSGPDTE
SVSEVHNLQLQDQDGEPLHVAFVRVTDHAGLDWIAAVAVPRATILADVSRLVELVMVAGA
LSLLLALLVGMRLFGRVADDVRSLSNAVQRVGRGEISSSFETTRQDEVGELARNFSHMRH
ELFTDRVTGISNRSALQHVLSNMVSKPAHGAPQPFAVLFIDLNLFKQLNDRWGHDNGDLA
LAEVAQRLRHQIRTDDHVARLGGDEFVMVLRGIGHRETAQAISAKMVDIISAPLTTLQGI
PAGETVQLGASIGIALFPHDAHDVHSLLQHADQRMYAQKANNPLSDKR
>A0A011Q3B7|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MTADTLPVDDVVGNALVPISGLLRLLRPTSAVGFAIKGLDGRYRLANPAIEELLCRPGEH
LAGRSEDELVPSPTCSLLAECDRRILAGETSAWARVLDRASPVAAHYSWLKMAILAPDQT
LQAIASLIEPVTRQQASPAIQETLRRLQDANRDLQQMVVELEQVASTDRLTGAWNRRRLE
ESVQSEMERMVRYGHSLCLLLIDVDHFKPINDQYGHAVGDAVLQRLTALLQAALRKVDSL
SRWGGEEFAVLCPNTARATAAAAAERLRQEVANAHFATVGRVSVSIGVAECAAGESWDEW
FARADAALYRAKSGGRNQVQVAPEVPCHGDGKGYVVANFVQLVWRSAYECGNEIVDRGHR
QLFADANRLLSAILTDQSADEIGTIVDRLLSDVVEHFRDEEAVITAAGFPAAGEHLLLHR
ALTAEAHRLLDHYRGGTRAAGDVFQFLAYEVVTKHMLGADRMFFDFLRPPEAAMNPAGQA
GPLA
>A0A174UMJ6|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MDKKKRLIQLTEGILLCCVIVVMTLLCIGIIKKEVKNTKGKLTETTGWYRIQDNKKVQVD
LNQKIKTDTQGKLVLYNDTIAQKYKGYLMTTKAAKYSVRIYAGDQLIYQYSDSNFHRNDQ
MKSKLSCDARIPEQGKKGTVIKIIYQNGSNGIYDLDDILVGRGDVVMGFHVQQEIVGIVM
IAIMFFLSFVALTTGIYLKHFKLNSTRFLNIAAFLALSGIWFLSDSALAQEYTSFPALTG
MISFYAFMLMSVPMVHFVKNTLKFEKYKVLDVINLLFYANALIQGILNKCLKIHMVHMLF
VTHVLLFIAVITIVVLMIEEYRRTKDSELKIIMNAFGIMAVAGVLSLCMYWKLEIPFYGT
IFEVGVLIFEQLLLTSIFVNLVEQAKTRSELEVYERLLKEDRMTGINNRTAFEEQLQDIE
DHVQDYDNAALIFMDVDGLKNTNDLYGHNAGDELIISAALCIKNVFATYGKCYRIGGDEF
CVLIFDSIENMDELLKQMDQEIIKYNRNNRYYLSITRGISFLKDTEGKQKKISDWKYEAD
QDMYCNKKRRNINDRL
>A0A2K9K542|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MYYIGHYEYESYEELFWFGISFTLFNLITREIANSFLRIALLVYCAGLLLDIIDNFTDGF
SIPLLNFDTSLKNIGFSLISFGFYCMITNKRASITELKKEVERRRLLEERMRYEADHDAM
TGVGSRRACFEGLQTHRFDDQWLLYLDLDNFKQVNDNYGHHIGDEVLIKFTQNMKDYFGL
DYSFRIGGDEFIAYINAVLPDTDEVRAALLKGLHDYKINVSIGMVKVDPAKQADLIIHEA
DEHMYGDKRGKSLSSSARG
>W5SZS0|diguanylate cyclase|EC 2.7.7.65|Borrelia coriaceae ATCC 43381|TrEMBL
MQNFDNLAKDIKNFSYVIDKNFLVWPQNSLLKPINTELIEKWDLKSEIKLQRAFFNESLI
TETRKLINVEYDEESIANYHILVSNLEEIYETCKRNKKIYYQDVLPTVKKVMEFYKKNQD
TFIKYMKVPKLLSDYHIVHSINTAILTVALGKEMNLNNHKMVELCTIALLHKIGFLFIPL
HISEKKEKLNDEEFEIIKKYPVLGHKILSSTNFSHSICLAILNHKENLDGSGYPNKLKSI
KINIESNMIGAASAYSAILLDRTYKGALNSGASLIELIQDADKKFDKRVLKLIIKVLSQC
PLDFIVELNDNSIAKIIKINDANINVPYIKYIIKDNKIIPPSENQNYVKSIPKTETGIKK
ILRQDEIEFISKKYGLKEI
>A0A173R1W1|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MYNKKKKIKHKTLKIFCLLIGMIVTAVFLEAGILYIVNSKNVYKTSKVLLDQTIEIVEKN
KQSEVGTVVADIPVYKGIALYVADKETGRIYGATDASKIGVKLDDMGFRKQRKTVAKEKI
VSGIIRVDGKKNYYILKKTQKYIVGVTYWIAVDNKSNLIAILIMVVYLSIAAIGILFMVL
RLSKVKKKNKEQSVMISSISEMSNIDKMTGCFNRKAYDEDISEIRMDSQFIYVSMDVNGL
KIINDRQGHAAGDELICVAASCMKCRFNKYGKVYRMGGDEFAAILFVKREQFEWIRRQFD
GDIKYWSCNRIKELSISYGYVSSSECQWDSMKEISDVADIRMYEEKAMYYKKNGVDRQGQ
PASYVALYRLYTQILRINLEKDRYKIINWEETKNKKKQDSIGALSEWFHNFEDIRLIHSD
DLVKYLKKTKIEYLKKQFANKKKFVTITYRRKEGDGYKRITLEIIPEDENSQNTYEGFLY
VKE
>A0A2K9JVT4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MPAADFDMNEIHWLMDMFNTVDVGLVVLDRDYKVCIWNGFMENHSGLLPSAVKDKDIFDL
FPSIDEQWFRSKAEPVFVLKNRSFTIWEQQPYIFRFKNYRPITGKADYMYQNATFIPLTT
VTGDVGHICVIIYDVTDEAINKLELESLNKQLEKISRTDSLTQLHNRGFWEESLKQEFKR
LKRNQGQSALLMFDIDHFKRINDEYGHSGGDEAIRHISDLLRKTLRETDTAGRYGGEEFA
VTLLDTDVKGAITFAERLRSLIENSSIYYDEQQIKITVSLGVAVYEESFEKHEQWIEAAD
SALYVSKEGGRNRVTVYSEDMASE
>A0A0E0XZA2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O104:H4 (strain 2011C-3493)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A628E4M5|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V8I7Y4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRCDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A757H2S5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A759NFP5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRTAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U5BXB5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A744ELK0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSPMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A750KLA2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPRIMNDENFYRKAVERAVAPPASQNEQQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVGGGWWLLLVGWTFVWPHLAWQLAAKARDPLSREIYNLKADAILAGMWIALMGVNLL
PAAALLMMMCMNLMGAGGPRLFFAGMALLWASCLVTLQLTGLPVATRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRQHWEILLRDEFDHCRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVVLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>F4VGK7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H591|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRSLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5Y3BD87|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDANQEREKK
>A0A5V5HG91|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5H7LMS1|diguanylate cyclase|EC 2.7.7.65|Salmonella moscow|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQVWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0L6ZCX1|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MNINNTDLDDQYKRDYLKLKDEFETYQSFAESTIQLLTEKNIRLEKKLDSITNIVEISKY
INSYLSKKELIPMINDMIIGILGATYCSIYLIEDDELTLKASNLRNQSSDLSHKELFKEC
FNGKPFIINSKEPIFDRNYNKSDIHSLIGVPIYLREKFIGYIIVEHALNNFFVHEHIKFI
STIANQIAIALENNNLYNQIRENSIRDPLLGIYNRKYFYDVVEDKLAKDNTRKFAIIMMD
LDNFKKANDLYGHQYGDEVLKLTVKTIEENIDKNDMLARYGGEEMVIFIEGFHSISEVFD
KIDKIRNKIKNTVVSYKEIQGSITASFGISYYPEDGKNLNEIISVADYRLYVAKKSGKNK
VVNH
>A0A0T9KCI0|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MNLKKNLIGELEKASFIDPLTNIYNRRKLFNLCEAMPTTSYPMAFALVDIDNFKSLNDTY
GHGVGDKVLIEFSKLLISYFRSTDIFSRYGGEEFAIVLNNGTPEDAIRIMNNLRLKVNQL
MLKLEDSTTVMFRISCGIAMLESYSEMKRAIKQADEALYYCKGNGKDRVSFYTADGFI
>A0A2H5ZFK3|diguanylate cyclase|EC 2.7.7.65|bacterium HR29|TrEMBL
MDPATDSGSSRRKVVLRLVSLALWGAVLAMFAVPAVREPSAGRVATALLFALLFVAANAQ
LVLVRWAGHRRVRQLNAKLRTSGYLSDEFDLPNRNYLLAELRREMPHAREHGSPFTLIVL
SLDDFEGIRERRGEDFAQRARRAFVDVLQRVTRGSDFLAHLGGATFAVLLTECTREQAFN
YLKRVPGTIGVSDGRRVYDVGVTARVSEYDMESLYATDVLRAAEEATPLRRKEEPRPWAE
AA
>A0A2P8B097|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MH33|TrEMBL
MGWLDRVEDQVDALRRARALQEASRSAEACALLDRVIRTTDDPRARADALVQRLSALINL
GRTAEFTRAVEEASAAVRDLAEPYLHGHLNALAALAAHHQGALDRCVTHLVRAARALGAD
DDPDRDTAWGWHDLAMAYSYLSFHGHALGAIERARQVGLTAGIPEETFAAPGIRLRNAVA
LDHNGDSDGCLRVLRDVAGDLSRFLRSGRAGNLRPSSLAAYGYAAARRAALGDRVDSGGD
ADPASLLGHGGDSARARDLRQLGQVCLAVGEGRPIEAVARLDTIRVSDETLGAAEAPRLR
SVALARAGDHAAAHRADRHAFRLAAQRSDRLRDVYIDGIAARIDHEEMRREAARYEGEAL
TDPLTGLPNRRRLERYIGAVVARGERVVIGVCDLDGFKAVNTRHGHHSGDLVLQRIAGVI
NRVMRRGDFVSRYGGDEFVVVLPETGMAEAAEVARRIQAAVHTEDWESLVPGTPVGVSIG
FAEVDGGTGVSVREALGAAFELADREMLRAKDRLRAC
>A0A377FVQ1|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MKFVTMRLGLILALSIATLVFLLTVTLTYTISQRSGASLEEEIGERLSMTSHQLVDKLDF
YMWSRYQEVQLLQGLDALNDPDSSRALLDQVQTNIPAFSWMGVTDASGNVVASTNGILEG
ANIGARPVFLEAQTEPFIGDVHEAVLLAELLPNPSGEPLQFVDISVPLFRDGAFQGVLAT
HLSWEWGKEVLRHFDRTLHHQSGYTDLFVMSERDNLVLLGPDELVGKPLGLTLEDGWHVV
TWPDGTDYLTGITKGEGYDDYSGLGWSVVVRQPVDVAFAPVASLERNILSFGLIAALVTA
ILGWLLASFITRPLQKITETAALMEQGKVKTFPHQSGIHEIESLASALESLVTSLTQAET
ERIHFETLANRDVLTGLANRTALRHYLNEAQTGQHEYVCFYIDLDGFKAINDTYGHASGD
DVLIEIARRLNETSLDSAYPVRLSGDEFFLLFERNGRSHRAIARIGDDIITALSQPISFE
NGTARVGASIGAALWRSDTVPHTAIERADQALYRSKANGKNQITLDETLIA
>A0A084XUY4|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MFKHDHSSLVHSSRRASRRLHRRPILPAMASAQPPGFLPAASGRAQHSHVRRFDTRKPEA
TALELLVAELRISDLERALSEARAAAHTDALTGALNRHGFAEAYQREAARSRRNHSSLAL
ALIDLDDFKRLNDTLGHQVGDEALVHLVKVIRSALRPSDILCRFGGEEFVVLLPETALNQ
ATNAISRFQRQLAAQAIPGQEIVLTFSAGVVVQKSGESLEQSILRADVATYAAKRAGKNC
VVTG
>A0A5M9ISS2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MDDTPGSNSLRNDFSDLNADMLHAVMELVSDGIWDWNANTGFVYRNPGWYEMFGYPPHSL
ENSVFTWENIIHPDDYPRVMAVFDDYLQRRSPHYQIEYRCRKKDGTYLWIEDRGYIIARN
LDDSVARMVGSHRNIQTRKSSIEQLERRNQSLEALVAERTRELSRVNQQLQLQLEENRSL
AERDALTRVANRYRLEKVLLEECDRAERFRLPLALVAMDIDDFKLINDRHGHGVGDQTLV
RVVEGLETCMRQGDLLARWGGDEFIVVLPKSPLEAAKALAERIRQRIAQLPAVGDFNVTL
SLGVVERRTGEPPAALMARADQALYRSKAAGKDIVSE
>A0A2P5IL08|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. PSNIH6|TrEMBL
MAALPHSVRKLRPELRVHLLFLAVFLFSSFLTWRELHVLKANYEDRQRAALADMQSRLES
QFQESIDGMIYYRRMFTYALAHPLDAHHARHALAKFQQLRPQPAWQLRLNMPRSMPINGV
GDSALVQDALLQRDPARLNDEMLAALEFSFIMQFSDAEADFHSRFWYTSRAGFFITSRPP
QSLSAISASYATMVSRPWFRAMATQVTPQQLSWSGVYQGAEEEGAMLTASTPVFNNGYWY
GALSMDFTRERIASELSTMRHSALQGSVVLLDKRQQLVASLDATDSRPLSDGAQRRLYAR
IARQPQGALRLENQFISWSKLKNMDGYLLNQQTLGQGLRQDLGRAMLFMLLMWLLFVLLL
LLADQIIVRLVRRLSQLSARLVWRASYDGLTQLLNRSAFFERFEAEVARCRALNAPLTVI
QLDIDHFKRVNDTWGHQAGDQALVRVAAIVSQGLRKNDLAGRVGGEEFCVVLPETGLADA
EKVAERMRERLAAKTILVNASQSFSVTLSAGVASSEEQGEYQAIRLQAEADRRLYLAKSQ
GRNRVVARG
>A0A8F9T8V3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MPLQAVRPKILGFISEQASAWLVALVVLLVGVALTAVLALTTADRHHQQVRQRFQLLVNE
RYSRLEERFEDQEQRLGSLQRFFVNSHDVSREDFDGFAQPLLLRARAYAWAPRVARDERR
AFEQQVSRQRGAPFSIRELNEAGALVPAQERDEYVPVLYSQTQSILGSPLGFDLLAQPLR
RSTIERAYRSATIAVSQPMSLVGVEPAYTMGVLLVAPVTRPPTAQMPYNEPYGFVMAVIS
MRQLVADGLPKPARDNLVMQIVDTSDTQQQLLYESDNPVGDSSLESIRRLTLGDHVYALS
LRPSQVFVQANHSSTSSILAMGSLLSLLLSALLYVLVSQRQRALRLVQQRTGQLHQREYE
LRGAHGQLRSVLNAATQVAIIATDLRGVISTFNAGAEKMLGYQADQVLGHMTLESLHLAP
ELEARAVQLSQALGKRIMPGQAMLVEGSDSLHEAREWTLVRQDGSQLTVNMLATALLDEH
GLWIGHLAICLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPNDNWRFIYASDG
IRDIYEIDPGLLQQDAKQVFERIHPQDAERIRASIRLSALQLSHWREEYRVQLPGRGLRW
IRGEATPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLKAEM
SRVRRTSGSLAVIMLDIDHFKRINDQHGHAAGDGVLQELCRRISLRLRRSDVFCRLGGEE
FMVLCPNTDGVQAYSLAVELWEVLRSTPMDGVGTVTASFGVASWRVDEGVDGLLLRADSA
VYAAKQAGRDRVEAQRLPA
>A0A8G0CR20|diguanylate cyclase|EC 2.7.7.65|Devosia salina|TrEMBL
MCSSSPHTLDFDAFVHGVTRARLGVWDWDLVTGDCVYSDSWYAMLGYASGELQPSSELWL
ELTHPDDRQRAIESGERHLRGETTEIETELRLKRKDGTWLWALDRGGIIERDELGRPTRM
IGVQTDITKQKAAELDLERANERFRLALDASDVGVWEVDFATETSYWDSRTREIFGLGGD
GESQPLNSWHAYLHPDDKASTEHAHENVGLETQVIRYRIVLPSAQIRHVETFAKLVPVPN
GANRVIGTIRDVTVETDQRAALQWAADHDGLTGLLNRTAFKQRLRVSLAAAGANPVCVLI
IDLDHFKAINDQGGHAAGDRALCQTANVLRWAVEGEDVARLGGDEFAAIVQGSVQEAETL
ANGIRRSIEGFGTDTKLSASIGVAGSSPTNRSASALIKSADLACYQAKRSGRNRVATAEG
AVLRAEGQS
>A0A0N0GQQ3|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MIAPDIPFDEASRLLLLSSLRILDSAPEEEFDRITRVARQAMNVQTALVSLIDTDRQWFK
SKIGLEACETPRDISFCGHAILSDELFVIGDAQQDPRFFDNPLVTQAPFIRFYAGYPIKS
LEGVRLGTLCVFDSRPRHLTSSEAAMLKDLGALVEREFAHRETATIAMQSHAKGLEQVLE
SRTDLDVTFEQAATGLAWVALDGTWMRVNQPLCDFLGYTNQELMALTFQDITYPDDLRID
LQSLEDLLAGLIDHYTLEKRYVRKDGQVVWAKLTVSLRHHADGTPQHFISVVEDIQRRKA
SESALKNLRDTLEQRVGERTAALQQANQSLSIAVNQQLEAQAQLRRSEALHRSVLETAAD
AFISIDAHGLIIEWNRKAEQIFGWSRAEVLGQLIEETLIPPTYRQRHTRGLVNFLQTGQA
VVLDRVLQLPARRRDGVDVPVEMTISHVSVDGQVRFNAFLRDVSARQEAEAAVRRSQQEL
RTITDSLPVLVAEIDTDGVYRFANATWHRWYGVEPGSLIGLKFGEAPPLQHSPQLQQYLR
RLHENPYATLEVQTLQEDGEHWEHYDAVPRPNADGKVGGYYVMVQDITARKELEHSLSRQ
AMEDALTGLSNRRGFEQHWHRATERAKRVGKECALLYLDLDGFKGVNDTHGHDVGDAVLI
AFAARLTQCIRQSDIPARLGGDEFVVVLEFLSQGMADAENVARKIIDAMREPLMAYDQAL
TLSTSIGIASFQSCGQDARMCVNMADEALYTAKRAGKNRYASAPIVNP
>L9UDC4|diguanylate cyclase|EC 2.7.7.65|Halomonas titanicae BH1|TrEMBL
MRYKDKHQLAAEWQALLERTPKPLRQAVETLVEHHGQNFADHFYRVMLEDPHASLFLSNA
QVEQRLHPSMQRWLKAMFAVDHADFESLVEQQEKVGQVHARIDIPVNLVLSGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIAAQQDIATLPRLSNSDFGLWYFHKACHAFEGVPEIATIS
RHIQQVDCEWLEVLLHDDASQRLKALGEIRDAARTVLMLLDNVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKELMLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A7Z0MEI4|diguanylate cyclase|EC 2.7.7.65|Alcaligenaceae bacterium|TrEMBL
MVKPCGARAGNRLSSQEWRPWGAFVLVLPEPTSFATMPIIDTDLHTRVSTAWCQQLEHTS
AEARHLAQRLAREHAVALVGHFYASMLEDADASEFLSHQMVEQRLAASLHRWLEEVLQGG
DAATIETLIARQVEIGNVHARIGIPAHLVAAGARLIKQTLNGHIEQADADTATRFQAVHY
ATGVIDLTVEAMIAAYSQAREQSVKEEEAYRYFVGVKNIGLERERQQSSLLEWENSVVFQ
LATGAPLANLPLLSVSTFGLWFKHKGHPVFNKDPQSGTVVALITACDTAVEALQHSRGGD
SPEARTGLLRQLHSNATQIKQLTQSMFEKMTELESGRDELTHLLNRRFLSTVLRREVALS
GRGRKSFSITMVDVDHFKAINDLHGHAAGDLALQSVAAVLLRNLRVSDYAFRYGGEEFLL
LLVETDVEKARMIGERIRREIADENVRLPGGESLKLTVSVGVAPHTGHPDYARTLAAADA
ALYRAKALGRNRVEVSPAGA
>A0A158S3H3|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. KN65.2|TrEMBL
MKGFPKTGNELSALIVDDDDVDRERLIRMLRRCPRDISIVEAASHAEAMTLIRMPASHFD
IVFLDFGLQDGDGRDLIPAIRDEIDPDCPIVAVTGNSNEQIAVDSIKSGMTEFLAKRQLS
QEQVLASIEEGMAWRKYRQELRRAEEELTHRSLHDPLTDLPNRTLFFDRLGQCCARARRH
GDAFAVLMLDLDRFKEINDSLGHAAGDLTLTVIAQRLRSHLREVDTVARLGGDEFAVILQ
AIDSTELALKMGQKLTDLIEQPVACGNRMLNVGGSIGIALCPEMGTEPQTLLSAADDAMY
LAKRGIDKVVIATDSRARPGPSLDRKGMLEELESAMSRDAVDWHWQPKIDLRSGRVLGFE
VLVRWRHPTGAPVPADQLIHTVEQSPLLESFTNHCLNKVLRQFAQIQDRIDEASIAVNIS
ARMLERAKFIDSLPELIARHGVEPRRVTLELTETALIANPAQAQRVIERLRKNGIGLSID
DFGSGFTSFGYLREFAISEIKIDRSFISRFTESRFDQSLVNSLVVLCENLGISLVAEGVE
TPETQQLLTTLGCNAGQGYGICRPMPYEDVLPWMAQRGDATPQHRLRA
>A0A158SQZ1|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. KN65.2|TrEMBL
MVAKVSEGKKDWQHCVDSALIGALGYALLAWTTIYVTSDLHAHATMWPADAVILALLLKH
PKRDWPYILLAGWCGNLIANVLTREWTPGLFLYGGINMGQTWLAAWLLLQVNKGDSLLDS
ARTVLGFVTCAGLVAPLVGAMAGTLVTFLSYGEDLGSSFLSWFLSNSLGYIVVTPFLKAL
FEGSYWHGFQSRGPTEKVEVLGLVGTHTLLTAFVFAQDNIPLLFLLTSSLLVLAFRHGNS
SVMAGVIIIAVIGAVATIRGAGPIAIMPYSKGAQEFYFQFYLVLLLATVLPVATIVSSRK
TVMHDLAEREEALRLMMSHSPDGILGFDVDGMCKWAEGPLRKYLGIEPGQMIGRSMDTVS
PLAQDLVREMHRAARNDIALPGTFEFTPMLRPELVLEGSIGLLRRNCCIAGAVINLRDVT
VRKDNEATLELKALKDDLTGLPNRQGLRVELEALAHSPIGSTSLAIVDVDCFKAINDAHG
HGVGDVVLREIAQRMKRSMREGDFIARIGGDEFAILLHCDLETARNACQRIVESVRQTPA
FSEDTVHILATVSCGVAEFRASDLPDQVFHAADVALYEMKRFGRNGVRAAA
>A0A5P9BDE3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MNKLVGRHLEEMADIRSTRKQKIVYSFSLTSAALFIFYTWAYFQDGYYTLSVFEMMFAVI
AVINAIYIKKVQEPHYCEILLSCVLLVQGVVLFLYSGTIPERMLWLYPILAAVIFINEFR
MGLILSVTFLLFLSGLMALIPHKFALPFNSTHRFSLSLVTMSAVCHVSSYYYTKAVGYIQ
RLYQEGIEDLAYRDQLTGLANRWSFERWAIEKLNTVNPNNSVTALVFLDIDNFKTINDSF
GHDVGDSVLQHFAQRLKNNVRNKDRSTHKHDYSIARFAGDEFVLMLYDVRSKQDLDGILQ
RISGLFENENLTNNQVGKLTLSIGVAMYPTDAKDLAELTRCADKAMYFAKHSGKNRFAYY
QDDLTTPLIEDMKCFEPCKSVETIPSNVTALHQQSS
>A0A5P9BAX8|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MSQITFEMDELHWALQVMDTIDVGLVVLDLDHNVCLWNSFMQSYSGINGDRILHQNLFEV
VPNLPQEWLKAQISACSELKSRIFSNWEDRPHIFDFKNYSPLSHQRINMYQNLVMTPLTS
LNGQVSHVCLMVQDVSDVASSKLQLRDSNERLSTMSRTDGLTGLFNRAYWESCLAREYES
AKLLSQPSALVIFDIDHFKNVNDTYGHGAGDEVIRQTARLLKKTARNSDLCGRYGGEEFT
VLLPGTTADQALYFAERLRKRVEKYVVDTSSGPINFTVSLGVCELSSCVASHLEWLESAD
KALYRSKQSGRNQTSLFPFE
>A0A1P8UXQ7|diguanylate cyclase|EC 2.7.7.65|Salipiger abyssi|TrEMBL
MTGRILIADGVPTNRIIMRVKLTAAYYEVLQAASGAEALLAVRREKPDLVLAATDLPDMT
GRDFCTRLRAMPDAADTPVILVHPQPDRGQRMRALAAGADDVLARPIDELVLQARLRSLL
RARHAQDELRLRDDTRRALGLAEPPAGLEVPARIAIVPVQMDIPLRDGIAAMRSCLPDRF
EEMTPEQALHLDAPVPEVFVIVDTGSMSGAGLSLLTQLRTSPDLRQTAIVYVTRADCRQE
AASALDLGANDLLVNGFDPEELILRLPKQISRKRTADRLRANMQHGLRAAVTDPLTGLYN
RRYALPHLARLSDRAAGQNRPYALLLADLDRFKQINDSHGHATGDAVLTEVARRISENLR
VADLVARIGGEEFLVAMPDTGREAALRTAERLRRVIECSTVTLPGDGARIGTTVSIGVAL
ARRGVTERPEALLDRADRALYKAKDAGRNRIALAEDTGWDDAGRAASAAP
>A0A7C6NLQ7|diguanylate cyclase|EC 2.7.7.65|Alcaligenaceae bacterium|TrEMBL
MVKQIALENKHVLASFFYEQMLQDQAAQLFLSHEAVQSRLMLSMQNWISQLFSVDGQADF
IALIELQRKVGEVHARIDLPVHLVLRGARTLKRKFADLLDAHAEEALEKRKEAFRLVSDS
LDIAMETMSRAYASSYDRKSRAEESYRLFSAVHNAAAEKGKQRSALLDWENQLMFDLAVG
TQVDNLLSIKKSDFGLWFLHKGLHAFENLPESKIIMDSIDRIESMTPQLEKNEERVSLLK
QIHAEARNIQLNVDILFDKYNELEAGRDELTRLLSRKYLSVVLSKEVAYARKRGITFALL
AIDIDFFKNINDTYGHEAGDMVLQQFSELLSNRSRAGDYVFRLGGEEFLILLVDVNKDAA
LRVAQQVSQKIRDEKFFIPNGEVLNLTASLGVTLFDGHPDYSKSLRRVDKALYQAKESGR
DQVVYIEG
>A0A5P9BJQ7|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MKAFVYIALASSVIGLAVLDFNVSAVSRIDSMAEFSQAIRNYTSKLNLSAAQDFPYNVPS
FAAVHVMKELNDLSVNMKYREVSNNPSNRQNLANDHEKKIIMGAKKSVAQYGFSSDIDHI
YLIRYDPIYVKESCLSCHGKVENASAQQHRHYGKKTGYGYKEGDLYGVKVISIDITWFLI
RYLAFLVIFVIPVIMWFKGFDKKLTEALNVDSLSGAYNKNYYLKSKDRLIDNGYVLLFDV
DDFKNINDTYGHTCGDNVIWQVCELIKSKCRKTDMLFRFGGEEFVLFLKGINSKERVISI
VGDIMTEISAHEFVHEGIKFNVTVSIGICKKAPSISTEDAISKADLAMYDVKKHGKNNFK
FAD
>A0A1X3L0E2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H420|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6S7A5P6|diguanylate cyclase|EC 2.7.7.65|Achromobacter pestifer|TrEMBL
MSSSKSAVPAWTDGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDVFY
STLLADAEAGPRLSHEIVSTRLHSGMKHWLKGLLCVRDQGDIVALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAERLRASDLDGNAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITESVSRLDDVVLPQLMMADEQRQVSMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIAISTRQGSRFSVLLLDIDHFKAVNDA
HGHAGGDHVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTAEAAALAAAEKLGAEIRR
HHFTIPEAGALRITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSVAA
>A0A5C5VL08|diguanylate cyclase|EC 2.7.7.65|Blastopirellula retiformator|TrEMBL
MRPFDIDAPSLQSLRPSQAERLLDVCAAHRQLTILMASIFCLAISAADIALGNEFPIAAL
CLPFVVAVCWVASLQTAVTLAIVCSIAWIVDDAFFLQSASPGVTMTEIWQTAVHVCFFLV
VLSVVTRLRGAYERERLFARIDSLTGLLNTAAFNDTAEREAARCRRTKSPLTVAFIDCDN
FKHVNDTLGHRAGDRLLKTVAKILCQSIRDMDVVARLGGDEFALLLPEATAEQAQIVIDR
VRSRLSEAMATESCPVTFSIGVAVYHKPEPDADSLLHGADQLMYDVKRNAKDGVAYHVV
>A0A376FIS9|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MVAIAIHNILQTRNDRFAQELLSRLLEERETLTDLSMMDPLTGLYNRRGLQSRLENLPTV
ENGEHFVLLMDIDHFKAYNDHYGHMMGDQALKRVSAAIRDAVRSRDIVARFGGEEFMVLA
DQYFTRTCSPDGRADPSESLRFENPASV
>A0A6C7CCX9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K|TrEMBL
MPHETLLENQGWFKKLARRFGPSHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNVDRLLFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYISRS
GFYLSTLPTAFGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQTYIADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGLLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQHSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7W6R4B2|diguanylate cyclase|EC 2.7.7.65|Rhizobium esperanzae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAPDGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKSSQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLARSGEGRADETAQVLLVDGRANSQERLIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTFGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAATVAERLRAAVESTPFMLKRAGEALNVTASFGI
ASRIAAVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A445NA62|diguanylate cyclase|EC 2.7.7.65|Streptomyces netropsis|TrEMBL
MNLILQALPIAAPSIGWAVHACFLVRRLRSARRDPLTGLMCREEFTTRSLRAIRHPQAAV
LLLDLNGFKQINDTHGHAVGDQVLAAVAKRLSAWCQARGGFAARLGGDEFTALVRLAPDA
DVDAEMTYSLSAALSAPLDTGGVTLSPRASIGVCRTADRPGAGLSDLLRGADEAMYTAKR
LGRHWQPAGPADVYGTTNGRRSGRPGTHLTLLAPTARRTAS
>A0A8E4F9D2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrae|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLVLVEEFYKKMLVEKESAEFFSDD
LIQQRLLDTLNAWLLESFSVGINKRYIEAVQKQHMVGHVHARVGIPSWLIMRGVCEIERK
VFELMAQKPQQDMITTCSYIVQIMGFSTEIMCRSYEAKTAVNQEIKHSYRLFSAMQDVAV
QKGKQRSSLLDWENELMFKVFSGNAGFHHPILSKSEFGLWFIHKASYAFTGSDQVQLIID
RIYQVDQLNTAVIQCTQKDEILGLIQQVRDLNREIQLLVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIISREITFSRQNRTPLSLLAIDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDVKRALNIAESIRKYVENGMITSSQGQQFRFTVSIGCVL
YNGHPDYQKFLDTADTALYAAKNSGRNRVYLAKNELQVAVANTAESVQL
>A0A5C5Y8C3|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MSDLNPSCPLESSANPAFAPVVAASPAASGPTNRPVAPTEIPPDSRVGDLLAGLRENALA
PADSGTAAQEAKFENHLAMVRLGMATSLYYALRTKHAPTAAHCLRVALACSAWAQRLGFN
DEARDRIEVAALLHDLGKIGIPDRILRKPGKLSVDEQLAMGTCPQIACEILRGCTADTEL
LDIIRYADTWYDSRRQDESMRGDALPLGSRMLSIASAFDAMTTDQVYRPALSRERAISEL
IRGSGTQFDPELSLDFGVMLEQRPELLQGAVVNRWLQKLGQDVDRPMIGGDAAALQVNTQ
STRKYVKRRDEFFLERLSDHMTEGMVFADGEGTVERWNHAMTRMTGIAADAIIGQRWKDE
TLRLRDTDGTRSGCPVTDCLGGGAQVSKKMMIERPGKDPLPVHIQVSPVMGSEPGLQGVV
VILHDLSDKADLEQRLEKLNNKVTRDPLTGVANRAEFDRQLLELTESAKSGEATFSLVIC
DIDHFKQVNDVHGHPAGDDALVQFARLLESHSRDDDLVARYGGEEFLLLTANCDNATATR
RAEAVRQALEVMPLKSIGNDCITASFGVTEFQSGDTSQTILARADRALLQAKSNGRNRVI
QLGSGRATDASESVGKRSGWLGWLDGNRKAAKEEFVVLTTVPLELAVEKLRGFIADHHAE
IIQVKADQLELRVNALCSSGGRRVADQQISLQVLLTLSDQMSGSRVRQTRVHAHIRPVRN
RDRRRRELHACVSQVISSLNCYLMGQVQSAEEA
>A0A4P7NYT6|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MRLPRLTRSIFLDQFIFMQLVGVLIGLAFPHFLVWYGFHAEEVMTVDFYIVSQIAGQMVG
LISFILISMVIRPHLKLLSHKMHEIAEGLQQKTFHEQTSRCEEELCQIDVVSDDEIGVSA
KAYNKMLEALIQAHEVERVFNRFSKVMSENLELSRLADETLALLIQSTNIEAGAVLVTKN
GVLEVGASRGILDAESLVKHDVINKAIKDGQQVRIELPKNIDLDGVLAQFKPSEVFIEPL
EFKGTNLGVLIAATGAMVADERTDQLVQLFSRSIGLAINNAMIHSKFQKMAAIDSLTAIY
NRRFGMDRLREDFSRAVREQSSLSLAMVDIDHFKSVNDTYGHLVGDKAIKLIATIIKKTL
REGDIVVRYGGEEFLMILHGASSTNARNVCERIRHQVKDTFFKEGNQQIQLTVSIGIAAY
PEQQAGDEMALIHMADQALYYAKEGGRNRVVPFRKVNEEVA
>A0A4U8Q116|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MNKKNKNTFRRILTCLSGILLITMLLNVIHTSALPDVRPKVEKCRLFQDGWQLEGKEGEA
VHFPFKLKNESGYIKLKNQLPQVKDGEKIIFNNGYQTVRVNIGQDCVYEYGFDTKPPVGN
MLGYISCQIPVSAKDSGKDITIELERPYKNLSGGVGSVKIGTTGAYVTEVLYSNVGKIGC
ILFLLLFGIVLLVVYSGLYIKKFNYNFDSFLYLGLFMVISSVWIWSDSELSQLMIGNSVA
LCILSFISFMAMPVYILSFVKNICEKKGKYIEQIQTVLWVNMIVQSLLYMGNIADFPQML
IITHTMMFLVIIILVAFLIYEAVKMNSRKAKGMLYAILCLTVFSIIALIRFYTNPMEDNS
KFFIYGLIVFLVILIYLNYEELFLYLKEKTQFELYEKMAYSDMMTQTLNRISFDEFMEEE
KEKDKNQEHKAPLAFVMLDLNNLKQTNDLYGHKSGDDVIKGAAECIKLEYGGVGDVYRIG
GDEFLVAIQKEDADLAELDRALKERIRIYNKVHCHDISIASGSAVRGTSNKDAETLFREA
DERMYSDKQQYKIKL
>A0A379W1Y7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPVSEYNHILVAVSFAVAIFASYTALNMAGRVAGSARSNARIWLMGGGFALGVGIWAMHF
VGMLAMDHAMNMRFDPFLTGLSMLIAIGSSLFALWLVSAEKLRLRRLLPGALVMGLGISA
MHYTGMAALQFASIIVWNSAWVALSIIIALLASCGALWLTFRLRHEGTDVALRRAGAAVL
MGIAIAGMHYAGMKAAHFPQNWPMEHRGVDSNWLAVLVSVVALTILGITLLVSLFDARLQ
ARTVLLASSLAQANQELAQLALHDTLTRLPNRVLLEDRLEQAISKANREGTSFALLFMDL
DGFKAVNDAYGYDIGDKLLVAVTHRLNQPLSGQFTLARIGGDEFVLLAEVSAPDEAASLA
SALVHSIDAPLR
>A0A509DW17|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MNTINQWVNGSGQPDFALIDRLARWQSKTWTFATLLGVLLLAITSLSLIFKQALSSSDLF
AFNSAFLTLVGGVLAYFVHKPQSFKRLWLIRLSSVIMLIAASYFLLEAWLEKQWIAQSIV
RTPVAFEPLTEFSIQTYLFFILYSVISCLEVHLKKPWWRILDGLTLILAFNVLLMFFGFC
LQCISASQTGVQAFYSLCITLCIFAMFMVLVIKRVQTGIFSVFVGVGIGSEVSRIIAPVL
VVLPLLIVGLCLFIDNFAVFSLIQVATMIAAVTACGLIGLSMRLANHVNGLEKQLMDMSL
TDDLTNIYNRRGFYLLGEHMLREGKRSGEPVMVLFFDLDGLKAVNDSSGHDVGSTLLVDF
AELLRSNFRSSDVVARVGGDEFAVVTQQDAYKVVLNRLKNTVESANRNHTKAYTLNYSVG
VASTVHRRRNERFDDLVKEADARMYARKKAKRSQAVMSQTHSADCAYLSEETIRI
>A0A554XQF9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MTIRETWRRWADEDRQVQDSAVRRNLQVLSLAAWVLVALNAVHIAVFGLLTFDEPVRDGW
ARQIATAHGAMAVVMALTGWLARRLHARPVLPIVGRILPLAVSAVVLAWAIVLTVMDQAV
SSSVNPYVNAAVGVAIVLLLRPSTMVGLMGMAWVALAWVLGGTTDDPAVLATNRMNAASA
TALAILVSILFWRHYARTELLQRALAESNRQLEAQRAELEALATRDPLTGLLNRREFVRQ
AEHELARARRLGAPLTLIMLDLDHFKAINDRHGHAVGDEVLRQTARYMAGSTRQTDRVAR
FGGEEFVLLLPDTSAEQAWHLADKLREGLARVCIPTLGVPVTASLGVASVLGTESVTLEA
VLHRADQAMYEAKRSGRNRTVVAADAGTGAA
>A0A5U3E9D0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A822WMI8|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MKAPATPENEIDRLNALRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHTLIVK
SADGQAPDSVPRNISFCGHTILTEAPLIVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RNGASVGSLCLIDYAPREFSATDLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSIARRRAEPLTLGWLDLDRFKEINDRYGHEEGDKALKTMAQLMRASFREADMLV
RFGGDEFAVLFADTDEKGAWIAMQYLAEQVENYNARKLHPWSLLFSWGLSEFDHNGNDLQ
QWLKDADEKMYAMKQQRQRAR
>A0A2U3EZN3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. CGMCC 5087|TrEMBL
MQRDTFVVRESYLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFVSTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSRTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A822X6I7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKEPDVLKAYQAKEGELKNIEHKVGQLKDTGATGEELALLYEGLKIVDGLQD
EQQAAIASVARGEEQQAIALLFGKIYELETERAQSKIDHFRMLLDKRIIADVQAATNTSK
TLRTASEVMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPNFNQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVIEVAELFAP
NIAPGIAGRLYIMDRNPWEMRCAAEWLSPQGEKNAFHPDQCWAIRRGQSHPPVNGEPDIG
CQHLPESQKDSSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQIAQAMRNDEPVSCMMIDIDHFKSINDRFGHEA
GDHVIKSVATIVQRAVHDAGLAFRFGGEEFLVLLTGADEEAAHACATEIYNGVHTLSLRY
GLAEIGPVDVSIGIASYPQHAQSDDLLRAADVALYRAKELGRSRIVSFSMLETG
>A0A822WN45|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MTSQSWLSLVNKKYQLSLRLFLFLNAASALFSVTNPLYSVRVLSVPLFAVMTISTGLLIW
HWKNSTRKINIPVVSAIFGLLWAWQIVSKFLLITHDHATYLMMALLTVLFIGSLAFASNI
KAFTLHSFPAFISCLWLSPSENWLRMAYFFALPVVAIGIHHVLQRRNDRFAQELLSELLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPKPDAGEHFVLLMDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVARFGGEEFMVLLSNIPLEQARQTAERIRQKVYDLKIPHM
FNESVATNVTISIGIAMFEGDDVEGALAKADKALYEAKHMGRNSILLSEELHTA
>A0A826X7J5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVHQTSVENRSWHKKLARRLGPGNIVNICFVVVLLCSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMHEALMTPLNFSALQNAITQFQQNRNKRYWQIGLDR
RRTLMINGVSDDFVSQSNLLSRADDDLHNELTAALEVGYLLRLSHAPGAAAQQAMYVSRA
GFFLSTQPTSNSKDILTRYFDFVTQPWFNEQSERMNKSRGVRWFSTPGDHTNETKPQITA
SIPLDNQGYWHGVLAMSIPLAAMRSLLVNATHNDTDGEYQLYDSKLNLLTTSTPEQRKIN
TFDDRERALLAQDIEHDTQGGIRMNSRFISWERLDHFDGVLVRVHTLQEGVHGDFGSISI
ALTLLWALFTTMLIISWIVIRKMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARFLA
QECRENQRPFSVIQVDLDHFKSINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEE
FCIVLPCANLAQAQEIAERIRLRLNEKEILIARSTTLRISASLGVSSTEETGDYDFEQLQ
SLADGRLYLAKQAGRNRVCASDQPLSEDKK
>A0A2S8JXZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGNYTQMVKERVYDLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLHDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A793CJY1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGTWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFADNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>J7QSG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFMRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGR
VGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVCASDNA
>A0A8H1MDF3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISSLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X7H2U5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQMIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVLGGAIVAHILSSHYESYDLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPIGDQVIKTVVNIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQGNALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A8H1ZF21|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A377DPT4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKNVGVTIS
>A0A7D7HKX8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRAYLMSHMPWLPFLLILLPANIMTMVMYAFRTERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDREHTEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSSIG
SVLVIQDVTEARKMLRQLSYSASHDTLTHLANRASFEKQLRILLQAVHSTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFIWEGRLHRVGASAGMTLINDSNHQAAEVMSQADIACYASKNGGRGQV
TVYEPQQATAHNERTVMSLDEQWRMTKENPLMMIAHGIASPRITETRNLWLISLKLWSSK
GELIDEQAFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSVAGPGSVTLV
DELLEQLEQSSLPPRLFHLVIPAEAIFDHGLAIQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMTDYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVLDTLSDIGVD
LIYGDVIAEGQPLESLVNSSYFAIN
>A0A827XSP3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTINSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSTLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8G8WVK6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINNIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFNGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9XZ66|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQVF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8G8PL82|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKDRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3F3NZM3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCSNVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A379CUQ2|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MKQHVNSAILGFSEQNLHTLLELISDGIWDWNANTGAVYRNPGWYSMLGYPRDSLSGTVG
TWENIIHPDDYPRVMEHFRRCITQDEQYQIEYRCQCRNGTYLWIEDRARIIARNPDGSVA
RMLGVHKNIDAAKRLILNLQQKNKSLETIIAERTAELLVLNQQLQHRLKEYKILLERDPL
TLAANRYGLERALSEQCERARLFRQPLSAIVLDVDDFKEINDKHGHLFGDTTLIKIADCI
RSSLREKDVVARWGGDEFVLVLPETAHEEAEQVACLIQRNVNQIRQPDEQQIKLTLSFGV
VQFCENETQIDFLERADKALYRAKGAGKNSISR
>A0A859W9Z7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHLQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A6L7CWY6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
LRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIF
EGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFY
GYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYA
>A0A2X3M1M9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKL
TVMVIFMCHIFSALRVTKNIAHRDPLNQYI
>A0A376W2R5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHFI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVLIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376P6P6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSSYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A377D0G4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALLFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLYIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRGKC
>A0A376JH35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKVLLDSDLGSSL
PLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLL
QIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVL
IIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENET
LRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGR
NRVELWKASL
>A0A2X1NDK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FLCDSARRESDGGCGSRRTYSPEVK
>A0A377K8V9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTERDLQPTDWCSFMEKDYLGISSTVLVSLLFGLALVLVNSWFNQPTVEEVVPRSTYLMV
MIALFFIDTVAFIFMQLYFIYDRRQFSNCILSLAFLSCLIYFIKTVIIIQQIIEGRLTSS
VVQNDIAIYYLFRQMSLCVLIFLALVNKVSENTKQRNLFSKKVTLCITLFFVLGGPIVAH
IFSSHYESYDLHIAELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVSV
IAFCAVLYNISLLFMSRYSVSIWYISRTIEVVSKLTVLVIFMCHIFSALRVTKDIAHRDP
LTNIFNRNYFFNELTVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIG
KSIRPDDLLARVGGEEFGVLLTEIDTECAKALAERIRENVERLTGDNPEYAIPQKVTISI
GAVVTQKNELNPKEIYQLADNALYEAKETGRNKVVVKEAEILINRKDDE
>A0A376U9N3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEKRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGYSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKTAVHDNLLWLFACNLRSMK
>A0A377AZ62|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMS
HYREWLKSADLALYKAKKAGRNRTKWRPDVRRKSSGFAEFF
>A0A418GQP5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQYNVDKLIFLRNGMREALVAQLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVS
DALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVSTLPTL
FTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVLVDSNNYW
YGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALL
AQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFT
SMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTHQHPF
SVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILPGANL
TQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLA
KQAGRNRVFASDNA
>A0A376W0W2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVT
LRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>A0A5B9ATJ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELT
EAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDA
NLAALNFYGYNHETMCQKHTREINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRH
VQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQM
QHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEF
VLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDAL
YRAKNDGRNRVLAA
>A0A376UA15|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LMGILKVMRCYAPSPAPLKVALAKAIWCFVGEAKSLSYCYQEPHWIPRFRWLKLSV
>A0A8B4ND79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTSPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376W3V3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNEN
ADISSLRERIQQQIRGEYHLGDVDLYYPGCQSWHSRSRS
>A0A348AEH3|diguanylate cyclase|EC 2.7.7.65|Methylomusa anaerophila|TrEMBL
MKINTKLKSIMLLSAILPLFVVIVVGRTELARNYNFDRAAAIGMVTAILLGLLGPKLVER
WLVTGSLAKIKDFCRQVKQNKYDGFDGLPNEEADSDAENEFISLMRDMNWMAHQIKCREQ
QLETTINDLTSTRSELLEQKQALEAANTSLLQMAMTDWMTKLPNRRHFFDHLEREMCRRN
RNIRSISLIIIDVDHFKRVNDCYGHQVGDSVLIELAAVLQQGLRLSDLAARIGGEEFCLL
LSDTGWEETLAVALRMQETIRNHVFHDCDGNVLQITCSMGMVHDRRPAAAEPELLYRYAD
RALYAAKEAGRNRVCYYDLESGVQPVSEQKISAS
>A0A1R3T7K1|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MLDAKTGMLIWSMQTLTIAAVLAVLWLHNPSKKYHLCFASGFALVGVGAILVLLRGEIPN
VLSIQVGNTIALSAFGFWLAGLLKLEDRKIDGWIAIPALIWVAFMFVPPVRDSMEARIIL
YHICAAVGYFMLAGVLVMSSEYISKTRKVLIGALIVQAFMGAITASLVIPYNLATGQVVP
LTAPVAVAGSFGFIVLLMISIKMFMEDTERRLQHLAMTDHLTGTLNRRGMTDAFEMLKTK
VGTKSRHIALILFDIDHFKNINDRYGHQRGDEVLVRFCAEAGEIVRGQGVLIRMGGEEFA
CLIETDDPSKAAILAEAIRIRFSRLALLADNERFFATVSAGVFCQRASDADLDAMLTMSD
RALYGAKKEGRNRTVVREGSINIVIPADDRDEDPCDNNADRQVAALTRITHIANR
>A0A379KYT0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MMIAHTPTLFAAVALVATILAFCLLLVGHGNRRDNLMLTGCGLLVHALAYVCYTLYAQAP
LWLSYGLGNSLLSLALAFYTASLFRVRERVVPWRVIFIIPAFMLVGLMLLLDTLEPRMLL
ATLVLMLQCALILYWAWRHGERPGKAHLLLEIGALISLVGLGMRVVAVANGKAVEMRYDT
SNLKQSISVAIGTVTVMMYSIGLVLMAKERSESRLQHLALHDVLTGTLNRRAILERFASE
LDRARGQQASLAVAMIDIDHFKRINDLYGHLAGDEVLCHCVRQLQQRLRQGDSLGRYGGE
EFLLLLPATDRAGALTAVQGLREAIARSPARFAGDHIELRFSVGLWCGVPGSKDSTASLL
AQADAALYQAKAAGRDTVHMVALDAAG
>A0A385EY53|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii WM99c|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKNQEELCANLNLIFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAKEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A1S7LL16|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MNVTQYRGEKFDDLHLFMGVGYESVSYALEDCMIRILEHNEILIDPDHPNDSLYVVLDGK
LRVHLGKLHHEPFLELEEGSCVGELSIIDSAPASAYVVCEGGARVLVVDEDKVWSLIYSS
HGVACNLLTILSKRMRHNNRVIIEGHDRQRTLENYAKVDPLTGIHNRRALDEALSRQLRR
VAHSKNPLCLIMLDVDHFKNYNDTYGHQGGDVALVALAQNIAGHLRPGDIAARYGGEEFT
VVLPDTRLEMAFKIAERLRKAVEAMDITDGTNTKLARVNISLGVAQTSTTITAVEPLIAA
ADAALYRAKNNGRNRVEVHTEEKAS
>A0A088TK82|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR1|TrEMBL
MNQSLKKPLVFFLVSFIILFVLAIWDYGIFHFAIDFFTIFIGLMMFVLAINSRVYTEKSI
YLVLAVSYLYISCFDVLHLISIFDISDMGLSYNESYQYFAIARVFEAFVFVIIFGFIKVP
SKVNYKLSHVIAAIVLIVGTLLIHQGVVSVYYIEGVGQSAIKLIVSYMTAALYLSSAYLV
QRSKFKLNQKNLLVIVLLLKAFSQVIHASFIDLGDIYQTVAMILRFASYGGLYLIFIREI
ISSPYQKVYELFESKEQELLLLSERDGLTGLFNHSLTFKNIERMIGDIGRKKYKDLCVIL
FDIDNFKQINDSFGHIKGDEMLVLFTTILQGIDFKDKMVGRYGGDEFVLAVPDCHKPDIE
GIFDVLNVILNEIAEEQGILITFSAGVVLWHMGDNATDLIRKADIKMYESKSKGKNQYTV
WQHELKKE
>A0A485CAE7|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MAAEYIRDKVRALNPEQHDTHRYIIDSNGNWFYWFNAADSVPFTFSSSQMANNPRAFFAE
PEMFYDRVLQKSMRKKSLSVTNFYEDKITGDKAYSVVSYIYDLSEGDPSNHIIGYLAYDL
SRSELLRMLQNAFNHQVPRALILGLQSRQTGEVMCIVNNCRWLDRHHIHEISSRYEITYA
MPVWLFILNDGNALAILAMAPALLILLFFLIRYHLNHADLRFYRDPLTGCFTRNIFALIQ
QRSLPFTTVILFDCNKFKQINDSYGHQAGDRALQAIAQCMLGDVRANGDWVIRSGGDEFI
VLLSRTDIAHAHIIAERIAAKIAVFPFSPEEQPVPLSVSWGVAPCLDSLDNAIQQADAQM
YQMKNNRGEKR
>A0A485AW15|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MHGEPDIICYHLPESCQDHTLCVPLIAQGEAIGLLSFQNLDAASTFSRGYLELMAEALGL
ALANQRLRDALLEKALYDPLTGLRNRHHLEDIMGTQMSQAIRNKEPISCLMIDIDHFKSI
NDRFGHEVGDGVIKSVAAIIQRVVREGGVAFRYGGEEFLVLLANMDEEAANRCATVIFNG
VREMPLRFGGVDVGHVDVSIGVASYPEHVQSDNLLRAADVALYRAKEMGRSRIVNFGMLE
AG
>A0A0T9TU15|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MSRSIISTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNTLESNRVYATK
LASSTEIFLKSAQKQLHYSSMIAAQHFDDQAILQAETARLKYQTDSFNSVVITDAHGVIR
ATSPDSLQLLGHVLTSPGSIEALKARRPLISKPYVSAANNLVVNISTPIITPDGRYRGYI
GGTIYLRKQSVLNELLGEHYYRDGSYIVVLDSERRILYHRDASRIGEVLAPRPLTEAAKT
ATNGSLMVTSSGGESMLAGYAVVEPSGWEIITLRPEASTLKPLEGLMIKGLGHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIAISIKEIPSWYFESTQLKRAMLIGISLLQ
KKIGKLKFEAQTDPMTGLYNRRGLATTLEPIAQLGQHFSVIALDIDHFKLINDTYGHDVG
DEVIKQLATQIRDSSRDTDILCRSGGEEFLMLLPGTTLDVATQVANRLRHNVEMMEIAKI
RPITISLGVAYWSGEAMPEDALKLADEALYRAKQQGRNRVVVS
>A0A5B9QX11|diguanylate cyclase|EC 2.7.7.65|Roseimaritima ulvae|TrEMBL
MLEFIFALVCGLGGLLAGYFLRGSLSQENETPAVDPAGEETTSEDALDRNTVNQVAEQLQ
RLTARVAADVDEHHTQVQRASNVLCDSDVPPTAESIVATVADLITANQHMQAKLEQAQER
IHEQSEQIQTAEARALTDSLTKVWNRRALDEQLQECHAKIGEQACSLMLVDVDHFKKFND
TYGHVAGDHVLTRVAVMLRARLADFAFVARYGGEEFAVLFAGRDINACRHQAELSRRAIG
EREIIFEDRSLRVKMSAGLAELQAGESVQDWLKRADAALYTSKQSGRNCGHWMDGDTPRP
LRDAQLNKTTALPALPAETSSGPAGQTLRVEAASGEQSLEAEAVGDAMTAPATADKTLAG
EPQLREHFGRLVDRLSKVSVELFVLVIRCDQARPATATDASILKVIRATTRSLDYIGQTS
NQDLVVCMPSANENSAVERAQRIRSGVEQSPAVAGVGPLTVSIGIACVSAEDDFDSVLSL
ATAAAEDVQQAGGNQLAVRRPQLIS
>A0A335ZP12|diguanylate cyclase|EC 2.7.7.65|Acinetobacter nosocomialis|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRAIHIYDSEHHLIAQSFKLSSQTSVLEKWFDHWF
LNEPVHLTIYHHQQNVGELTLFGSSEKILQFLKMIMVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQILLDMFEDKDFDNKSALLFIDNNNFKSINDQFGHLAGDE
VLKEMAKRLQTRLRHQDFIARLGGDEFAVILHSITHADHLISIAENLLESCKEPLHLNDQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKTSEQHWFIYKPEN
>A0A5D4YBB0|diguanylate cyclase|EC 2.7.7.65|Lelliottia nimipressuralis|TrEMBL
MFPKIMNDDNFYNKDVTREEWPQNLSQDDHHRSGIRFARRVRLPRMFGLAAMFFPVAGAL
VAQSPPGLWWLVLVGWAFVWPHLAWQLAYRAADPRASEIKNLKVDAIMAGIWMGLMGLNV
LPTAALTIMIGMNLMGAGGVKLFTAGATLTIIAALITLKLTGVSPTFTLSSQELWLALPA
MVLYPVYFAWVSYQTAIRLAEHKRRLELMSTRDGMTGVFNRRHWEILLRNEYDTCRRSHR
EAAILIIDIDHFKSINDTWGHDVGDEAIIAVTRQLQLALRAGDLIGRFGGDEFAVIMSGT
PAESAIAAMSRVHERLATLTLPCAPQVRLRISVGVATLTPEFGHYREWLKAADVALYKAK
NAGRNRTEVAA
>A0A1V6F5E8|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.Bin100|TrEMBL
MVQHAGDSLAQSQWAERGRMPFFSLGPDTSREVTYLVRISHARVPFSGGLFLKTQVVASD
QEQRAQFFLGGYFGLAALAVFVALANALVYRDRGFGAYAIYVLAMILGQAGITGVGGMLF
WPEMPALNNPMTFFMPLLAGALGVWFVRIVATPQQYSTLLDRLAVSIILGLIAVAGIDAV
VPSVIGFELSLYLLALSMGVVLLLLGLAIARGDRHSRWIAAGYALIVLGGIFPVARNFGL
IQSGFLSEYGLMLGSAMEMPLLFYGLNRRLNEQTETRARARALAVTDPLTGLTSHRRLLT
QLQASINRARNGRPFALMVVELANHAALARELGREGAERALVLAASRLRRVVRGTDTVAR
VGAQHFAVLMDSPCSLDEANAIATHAVAQGLRENEVLPPGASLRFHVALGQLPMVDLDAV
ATLDMLLAELKAISLDARKTIRVVKR
>A0A2P4URP3|diguanylate cyclase|EC 2.7.7.65|Actinomadura rubteroloni|TrEMBL
MTAVQSSAEDRGGDLTQKPSWRGLSGRPSVTAVYVSVVIAVHVFLTVGALLEAPLRLNDL
GTFGAILACGVVCIEASRRLGMPAGVARDLLSAWWLPAALLLPPAYALVVPIPLQLLLQF
RVRRTLLYRRLLLMAAHGIAAAVASVLFHLVVPDPLAGTGWVVDVTPGIPVAVGCAVLFT
VISTFIVAIAAHAANPESGWKDVLWTRESLLLDLVELCVGVTVSICATISLGLLLLALPP
AVLLQRSLMHQQLQAAARTDAKTGLLNAVAWQREADTELSRAQRGHDSLALLLIDIDYFK
RVNDTHGHLIGDQVLIGVASTLCHQLRDYDIVGRFGGEEFVVLLPGADTVEACRVAERLR
GRVRRLAVPAEEGTVSVTISIGVALFRMHGADMIEMLAAADLALYRAKQSGRDRVCLPAL
DGPRTL
>A0A2S9Y7C8|diguanylate cyclase|EC 2.7.7.65|Bacillus sp. M21|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCTHQQTIENIHPKCMFIANSFEEGEVLFQR
TKPHIVIMYVTDFSQIKYIKNMYNPQSTFIVIWDQQITSEFAEVLTLGIRNIVIAPVTPQ
MVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFRNDLLFIVEDDEIVDCNTNFLEFFGYEN
LFAYREQHLVFAEHLIRENGYYSTTHDITWLDDTLSYDRRIKMSNYEGEVSTFLLRATPL
PEDLSRFIVKCTEITELDEIYQEQERLAMIDSLTEIYNRLKFQQILEAEWDNAMRNNENI
ALILFDIDNFKAVNDTYGHDFGDLALIELAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFSGISKLTASFGVALYEKGITREELMQRADIALYEAKKNGKN
QVCIYRKEKK
>A0A8F7M4X0|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MDKRAVSKKTWSLVARMRLGLLLLFIPVLMLGAIYYLHMERSLQRELQQRLLATNHQLRH
VFIEPYLHELERQFSLIYDRVRVEDISGPRLLNTETYLREWRLYKGVMADLVYIYVGTAE
RQMLIYPAWQADAGFDPRTRPWYQLASQHLGEMVWTEPYYDYTNGNLVIALARAITDKEG
KVRGVFAVDAILAPFSAQLNRQWNSGYQMIVNQSGKVLAHPDPSRLLKPMTHPSWLSRFN
GADGIFLDPESRQFVAYSRLPERNWVLISVLPASSIQAVVASASLNVLGIIVLASVLYVV
LALIWSRYFRRMVDEISTRIRASRTQPEGLSHGGMRELRHVYAELAEVSKDYHEARQQAN
LDKLTGLYNRRFFDERLNRLLLDQHPFCLAMIDLDGFKRVNDTYGHQTGDVVLKRVSSLG
ARLLGDHGWVCRYGGEELVVLFANPDVHFCLMLLEQFRKGVESLDWREPGLGITFSGGLV
ASAPGMDARHLLAMVDAEVYRAKRDGKNRIHLGEAAPSNDLQSDDGMLSKEEA
>A0A8G0TEC4|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MNNDGYTSLSNFIDLLLDAICVVDKTGRFEFVSAGAERIFGYTPAEMIGMQMLDLVLPED
RERTLATANEIMTGRYKVDFENRYVRKDGTVVDILWSARWSEVHQQRVAVARDISKSKNA
ERRQAALYEISEAVHVAEDLLALYRRIHEIIAKLLPAANFAIALYDQDLNELSFPYKAAA
GDNSLVDIASFSVFTEQVIHSAESLLLCPLSLTEYPQAIREELGNGNLSWLGVPLKLQKG
VIGALMMHSLPTSASYTHQDRELLEFVSTQIAFAIERRQMLARLEHIALYDQLTLLPNRE
LFYDRFQKALSRAHRESSYFSLLYLDLDKFKWVNDTFGHSVGDLLLQVTAQRILSCVRGS
DTVARFGGDEFVILLERVDSAQNTLLAAHKILQVLNQPFELADQQIHILPSIGIALYPEH
GMDEKQLLSCADAAMYKAKKNGGNRIEMGYQGLRNLNADPLPAASESEESESEESELEDA
ELNNLENKVTKIV
>A0A8G0U0F7|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MIYSFHNSGFRDPETGVYNQTYFMEVFNREWHRHMREHQSLALLYLCPHIHETVKQPHLL
EFFTKQVQEALLRATDMIARLDHNHFALGLFNIDEEGTEVVLERIDQHIRKFNQEFGKNH
KLKIDYKLAACICTPTQKQKVDVLFASVSKLSQELEKEQLQSQALIRLQ
>A0A3S4PTS4|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MSRDLLQTAALNLKKAVPLMLKHQIPTTPINYALWYTYVGEQNPALNAQLDTVIAHYNTC
PPVSSELLFRQYVADPVELDVRDMRLNLEAMATELSQSIRDTNLDATEFQTCINNNFAKL
NGIEEGALSVEQVLDLVRNLVKESENIRSSTEYFTSQLQKAQTEIDALKQKLEKSEKDVL
YDALTGCLNRRAFDADLAGMLAQAPEGTCLILVDIDHFKAFNDNYGHQLGDQVLRAVSKR
LQEACRDGCKLYRFGGEEFAIIVPKSQLRIARQLAEAMRRGLEKLSLKDRRKDQRIDNIT
ASFGVAQWQEKQVAIHLIERADMLLYEAKRLGRNRVMPMSN
>A0A8G0TTP0|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MNNDEYTSLSQFIDLLLDAICVVDKTGRFEFVSAGAERIFGYTPEEMIGMQMLELVLPED
RERTLATAKEIMDGRFKVDFENRYVRKDGSIVDILWSARWSEDHQQRVAVARDITKRKNA
ERRQAALYEISEAVHVTEDLLALYQHIHQIMAKLLPAENFAIALYDQDLQELSFPYRVST
QENSAVDIESFRVFTEQVIQNAESILLCPISLNEYPKGAAAELGNSRLSWLGVPLKLQKG
VIGALMMHTDPTSAPYTYQDYELVEFVSTQIAFAIERRQMLARLEHIALYDQLTQLPNRA
LFYDRFQKALSRAHREGSYFSLLYLDLDKFKWVNDTYGHSVGDLLLQVTAQRILGCVRAS
DTVARFGGDEFVILLERVDSAKNTLVTAQKILQVLNQPFELIDQQVQILPSIGIAMYPEH
GIDEKQLISCADTAMYKAKKNGGNRIEMGYQGLRSIFVDTILPLELHPTNAKKVI
>A0A1C5TPA0|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MPDEKVLQVAILIWGCAFCAIAALCIFLSSNYDREKRWYLILMESFASMLLLMDALGHIF
SGYPGVPGSVMVRISSFLVFLLSDVVLVCFHIYVCVYLFSKKERRTLKRVKAGYVIAAAG
AAFVVISQFTHWYYYIDGDNCYHRAPLYIMSILLSAASLLIDLTLLLQYKKRVSRKLRFS
MLSCVVLLAVAAVVQVFWYGISLIDFSVGISMIIMFIVTMTELNQEMYQLISREGKIKER
LEIATILNKCIAELISGEDEDAAISNLLRIISGYFDGDRSYIVQIDEKRNVCTNTYEYAM
NGVTAEKDNLQEVPMEMLDIWMDSFRKNGLYYIPDIEEEQGQPYYETLKMQDITRLLAVP
LNSDGKIIGFLGVDNPRLHYEDHTLLSSIQYFLTDSLKAKERKARLQYMSYRDMLTTLYN
RNRYIQVLEGMQAKTVIKTGVAYIDINGLKRVNDLYGHEAGDRLIINTARSMLAILPENA
YRVGGDEFVLICFDMDEKVFRSKVRDICDSIAAKRISVSVGVVWEESSSELETMLRRADD
LMYAEKKKYYEKHGTM
>A0A1C6I747|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MYTVEEIKNKVKTGTWTKEDVARCVEELKQISDFIVYTEEIYYISYGIFAYNFREYAYSL
IEICREAGVHMERSKEKSRLYLALVRLYFCLGFPPKIVEYGLKYANSGFTLRSPLKSVYN
TIVAAFSDCGLFFEADFYLEKMMDISRLDPCDSSVDFWNSDTLNELVYYDSKVYVKLGMG
DVAGAEQASVDMQAILTEREIPEDGRAFFLLQKEFTDLYLRLYQQKDKAVIAEEFNNYMK
KMEAGEGARDTLSFCVCYFGEFLQVMAEEERWDDIIRIGNYIKNARNFSGSFCPVYKLMR
TAACRSDREELRRQIPEFERMYLEALEQEKENYDQMVRLLTREELRIERLKTSMERDALT
GCLNRAAFDHNSKRFMKNHKKGSLVFIDLDYLKLINDCYGHENGDRYLVCFAENMKCAMD
RQDLLYRYAGDEFLILSALEPEQIQERLNEILEKSPIHFDINGEIRNISFSYGIVAFEEK
KGKIADLVKEADQRMYQCKSRNHERISKRGAAE
>A0A1F2Q406|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MFASIGGYIAFFHNPKLQVGHLVFASMVTVFSGWTLLFGPAADVGLGLAKIAVVMATIIV
IPVVSQIVLAVLGSDATTSDIDPLTGLLNRRGLSRRVKDLMGPPVTEADAVLVVVIDLDR
FKTINDVHGHDVGDSTILRTALRIRLWTTKAALTARVGGDEFVVVERVPVSVIARLEGQI
RSAMDGATDDPPTSASIGMAVRTAPRHPGESVDEAFAELFRVADSVMYEAKREGGNQVRA
SLV
>A0A376DEZ4|diguanylate cyclase|EC 2.7.7.65|Edwardsiella hoshinae|TrEMBL
MSPLQSLDLLYINACVTYATLSVSYFALSQQRALGPYSPLPGRILWGVIAGLLSWYLSGS
KMPVSAHIHYSFEIVPMILVTFFAGWCAGLTAWLLNFITTGGFVLDNLFIGLMLAPLLLS
RIWQRNTLRVFILCISLVALFHLLIIVPELAQRIELLDALLHQVIAYCCLLLCYQTLTLK
QRSINAYFTLRESALRDQLTQTYNRQGLQQQILTLERERRPCCIAMIDIDNFKQINDHYG
HLCGDQVLITLAKMANQTLSPQDYIARFGGEEFIILFTGLEITQANARCEHLRRLISHAP
LYLGHGQRAWVTASFGLTHFDGHSNLKHAIAQADEALYRAKRQGKNCIIVT
>A0A376D9C2|diguanylate cyclase|EC 2.7.7.65|Edwardsiella hoshinae|TrEMBL
MEGKAPRVSRCGGPLGVSLLSLTIISYVLILYAAEYPITLLYGFVAVCNAVLLILHLLIA
IFIFMQFNCDRTQVYKLPLIAAYILSALILSYSLLFYPDVFQSRNSHALTLNDFVLFYLL
RYGGMGMLFLYALYLFVRGRTGLGGHRSVPAICAAIVSLVTLSALLLSSRTAWPNPAILQ
ESLSYHADYRYLLLPTMGALWAGVALLLIWQTRLATHFWLAVTLACLAIVGGFLLQWRAP
HVNSVGWYGSLLFGLLANFCVMAIFLYDIFQRYRCMQHAYVITHDNAIRDGLTRAYNRSY
YYDALHHALPQASAERPLAILIIDIDHFKQVNDRYGHLSGDRALIAVSDVIEQSLSAGDV
LARIGGDELCVLLLAVENEAGLYRLAEQIREQVAALAFRAQDGQPVALTLSIGGVVCRTA
RQSAEGYMVQADSALYQAKQTGRNRVVLAPGTS
>A0A1V5W3X1|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MDSAIVNWLKKTEIFASLQGRELSLIESSCDVCHFNQGDTIINEGDYSSSLYLIVSGKIH
VVKTDKWEGDTLIAELVEGDLIGELEFFTEGSFNHSFKAVTDVSLVKFPSDDKSYSDLLK
ENPEISALILYQFLKVFSSRLRKANILVKDNSALVTELKRQVYGDKLTGLYNKTYLEETL
PSLLKSRSNPVALLLMKPDNFKLINDTFGHEAGDNTLKIMAVALKRWTEGYGTVLRYMGN
ELGVILEGYDRERAYEVAAGILKMFNELDISDATGSKDIFLSMSIGIAVYPDHADIADEL
IARAHELPLVGRERGGNQILFPEDR
>A0A1S8NZR5|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MAIFSPVQVNIVLFILLLILFGHTYFNMNRKNITNRLFMWIMGLTAFAIMLEILSVILNN
PNLKQFMVMQKIVNVLGFTVTPIIPFLGYIFSKEWVNRYQKDKIKLNKILLLPLLINGIM
AFISYSVNVLFYVTSENTYERGPLFFILPCVSYFYFGYNLYFIYKQRKRFSWWELRIFNL
FYIAAGVFTGIQIVYSSYLTIWNGTAMMIVIIYIFILNDQVHRDRLTGLENYSSYERYIE
NISFKRINKLFIINIDIDDFKSVNDKYGHNEGDEALKMFANLLIESFSLRRKKLIRVGGD
EFLILLEVERQEIVDNYIQNLNKNIEAYNKTKEKPYELKFSYGVACCSNAKEDIHDILKC
ADKLMYEQKKSRKMKL
>A0A8F9USS8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MTHKAIQSLLFKRFAIAAGTYALILLLFWLAVVTGHSRASSGSALLGTGLVLASQVLLCW
VFVSGRNLQFADPSLTEVQVVLGIAWQTWLMAHLDQARGVFLVFYLLPLLFGLFHLSRRA
YLRSAALIFFCFAGVNLWDGYRLLLGDPQLAALQVCVLLVMLVWMCLYAAYVQASRSRMR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRIASRELQAMDQEQVHGLALI
DLDHFKRINDLHGHAAGDQVLQAFAAVATACLRDGDVLARYGGEEFVVLLPECDAERLTS
CCERLRLAFTEVQLVGLNVRDLSLSAGMTLLRAGDDLDHALQRADQALYRAKRDGRNRCS
AAWENLDA
>A0A8E6KV82|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000540|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7R6W7F1|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MQWLNRYSLSTKALLTGIMVGFLLWLSMDFLQKQQLDKLFNDELLTQLEYDSQSAQSHFY
KAIEEHAKIVTLFAKQKSIVDFILANKPNSLPQSTPPQWVPEMITWRGLILPSAFILYDK
NHQPIDQYNIYADETLPAMFTQDASDWLNASVKSPMLSQVDGNPALIVSAAIFYQQQVIG
FITIFVRIDDHFMYSELAQDLSPGAIAVLFAKDTDTLSVLTSSDLVRAPKGALATNLQQS
YLFGGKGLFDQGDWSLQAKLFILLPQGTKDHLAISVRHLERQQRFIAAIIFVAVFTLLMV
LLSRRIQHISNSISRFAKNELDITLSQDLNVDAVANLQECFDKLSIEITESHYKLLLQHE
MERKVDQLQILESVTDSLRVGVLERDAENWAILNSPMHQFVNDIGDISPFIVENSQQSLV
DKSGERRIFTISHMETDTRSLILVNEVTELAIKTEELTKMALYDALTGLPNRVLFHDRLN
QLIDCSKRNKETFSVLLIDLDHFKEVNDTLGHSTGDQLLFEVAYRFSQYIRSTDTFARIG
GDEFAIILPHADAKTAELVAHKLVDAQQQPYQILTHAINVGASIGIVTYPDNGRVADLIM
SRADMAMYHAKRNHFGFFFYQSEIDSSDQERLRLVADLRVAIQRKAISVYYQPQLHLESK
TISGWEALARWYHTEHGWISPEVFIPIAEENGLINAISSIVLQQAILDCSQWQSAGQSGG
VSINLSTRDLIDSQLTQKVALILAENQLGAEQVTLEVTESTLMQDPVKAKHELELLDKLG
VSLSVDDFGTGYSSLAYLKHLPVDEVKIDQVFVKNIIADPSDAAIVRAVLGLAQNLKLKV
VAEGVESKDIYQQLEHFGCDFIQGYYLAKPMSFDQLINFNINHIDTGELTTKG
>A0A7R6W8N1|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MKILIAEDDVTSRVLLEALTRKWGYTPVTAEDGEAAWQILQAENPPRLLLVDWEMPHLSG
LSLCQRIRRQVDTDPVFIILLTARNETLDIVSGLEAGANEYITKPFNQIELKARVQVGHR
MLQLQSELNQAKEALLFQASHDVLTGLLNRRAILTALDTEMARAQRQQQALCVAMCDIDF
FKQVNDNYGHLAGDYVLHEIAQHISSELRPFDLVGRYGGEEFLLILNAPVNEADKIFERI
RSSIETARFTHNQQVLKVTISCGISIFTPPTDHRNALDLIDSADKALYSAKESGRNVVVF
AD
>A0A8F9WP34|diguanylate cyclase|EC 2.7.7.65|Mycobacterium pallens|TrEMBL
MAPAEQPNPEDELRQLRQLVNHLPGIVGYWDRNLRNVIANDAYLGYFAMAPHQVHGRHIR
EVLGETVYALNLPYIMGALAGRPQLFERELVGLGGIRRRTLLSYIPDIVDGEVLGFYIQG
TDLTEEADAERALDDGRRLFEISMANAPYGKAVVTTTGEMLLANPALCALIGYGADELVG
RDYRDFVHPDDVAAGEQEMASLLAGTVTQISSERRYVRRDGSVIWMQRSAVLVPGRLPGA
EDLVIAQFQDVTARRHAEAELARLAVTDQLTGLFNRRALVSRVAEHQAGRPWAAVGLIFI
DLDGFKHVNDTHGHATGDVVLAEVARRLSDAVCEPNSAYRLGGDEFVVLVPDAAHDTEVG
ELAAAVRSALTGRYTADSSEFGLTASVGWTWGHDDNAEELIRKADIDMYRQKARRGQSAV
RGNPNI
>Q8E9F9|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MFRDEDETTPPRAREVERLKKRLYRLKYLAHKYKRAEVVQNALLELSHIATQVSSLEEFY
LGVHHHLKQLISADNFFIATLDVNSGAISVPFFADEKDAHPSQLYPEQSLSTLLQQGLTG
YVFRTGQTLLCDESKVDELVNAEEIVNLGSPCHLWLGVPIKHEDIVTAVLVVQTYDTNVS
YGDIEVELMTFICHHITGVMERLKHQEQLEQAIQQRTKELSQAYDKLKQEVYERRRAERL
QKSLFEIAELASSGSDNPVFYTQLHNVIRHLIPANNCYIALLNEESTHLTFPFYVSQIEN
QHPGARPLQDGLTEYMLKHKRPLLLDQNDINNLIAAKEIYAKAPTLNHTQTMHQWIGIPL
FIHDEVRGALTIYSFSMTQNYQTKDLELLTFVSQHIGAAIEKKLAAESLRRSYEELEEKV
AARTTALAELNKDLEKEIRQRRNMEAKLVHDAKHDALTGLPNRAMFMERLNHAIKHVRRH
SLEQFALLFIDLDRFKLINDTMGHLEGDRFLIETATRLRSCIRSNDTLARLGGDEFVILL
DTINDMNDARDVAERVIRKISQSYHFGTIEFHSGASIGITISGNKLDTSESMLRNADTAM
YQAKANGKGCYVIFDDSASQQKMQDIAFENDFRQALQADELQLNFLPIVDLQTRQTRSLE
CRLSWEHPQWGSIPQEVLNKLAEQANLQVELDKYAIRLLDKCYHQLLISHGDNLDLHLML
SSQHLKHKHVLRGLKTTLKQTQLPLSQLWLFFNEKALVQETENHISGFELLNKLGVNLGI
SHYGSGHSPLNSLLFLPLKGLKLDANITKQLQDEQHIKLMSAYQKAASTLELQTFVDGLQ
SPEQINIFHALGYRFGQGCALASPFALVETQQLVCA
>Q320D6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAA
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLL
PRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAK
NDGRNRVLAA
>A0A5A9BY85|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A8B4DZA7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MRHRALIITTVGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
LGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWADISMVVGACTLSAPAS
RLGALAHMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLMGWNVRLGEATWFDQYVYSAPA
LSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPLTGLLNRRGVQVALSSLLSGQRATRIV
AVVLVDVDELKELNDRLGHDAGDESIRAVAAMLATTTRASDFTARMGGDEFMVVGFFDHA
DEATGLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIERRN
GFHAVP
>A0A0P1EPM3|diguanylate cyclase|EC 2.7.7.65|Shimia marina|TrEMBL
MRVTNTRQKWLFVLIVTASSVLASLIITAFLSPTGLSSVAFIPAVSVPLIVAPIASYVAA
QMMLRIYELNARLTYLATHDQMTGLLNRGAFFERLEDLGRQRSGALMMADIDKFKNINDT
FGHDVGDKVICSVAKTIHAQAGQGSVVARFGGEEFVAFCPGVIAEDAVALAELVRAAVAQ
QEVHLEGEVLKVTVSIGLKPMGEACDVDQALTSADQALYVAKRDGRNKVVSQAA
>A0A259UZM9|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MSEQQTNQLVAELTAELESLQTENVRLKETQQQIAEINNNYLMLHYLTSSIQACQTTREL
WETYLHNLSDCGFNYDHVAVLLADEDGNFTERLTLAAGKVVQTTVLQTNGYILQAISTKA
AVTSPDNLKAALPIAGKSGKITAILLAEKASGIFFEDLQLLDVYIRQTAALIDNIMLTEK
LRHFQELLGRQLDQFVMLHYVTKAIHDAGNYYDVLEKYLTTLCSSLGFDFREGILYILAE
NKLQRASLQGEQLELVEMEAAEGQFLESVVKTKQYKLSDDSRHLLMPLNSFGNVTAVIEI
NHDVPITPEQIQILEIFAMQTSSAIDNTRLKLHLEYVSFHDQLTGLYNRAYFEREIQRIE
KEDTKPVGLIICDLDGLKVINDTCGHAAGDYFIATAAELIKTVVPANTIAARIGGDEFAI
VIPGSTAKTTKQTGLALKKELRNYNARLPVMPLGMSVGWATRTKLIKMIDVFKQADSRMY
QDKYLHGEASRNYILKMLTQRQQGKS
>A0A259UDM5|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MLEYIIQIDFVNCPGLGYEIFRITEKNNVDKIAMEVIPKHGMIIQFQCAAEEQAQRLVAE
LTELKNITAVTFRTQMPYQEKEIELRTILNSVSEGVLAIDKNGIISHINEVACKILDCKL
EETIGLKVEKLVGEDPPILETLCLGHVYRLKERTIKRKGKTLQFLASNIPIRNDQGQIIG
AVSTIQDFQQVEKVILQAGKSCKK
>A0A5B0T0F1|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHMLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDNRMTTTFSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMCMAASAAESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRIEVYQE
>A0A0D8FU95|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MDESLVRYLEVLQRPLALVEAERVLWVNGALTDLLATAREDLIGRDLPIAGGLKLDRLRR
SSTEAALRHATGYLLDVVITTTLVSAETWMLEFAMADYEDHKSADYFRKLQALADNLPIG
ILISESGLRLGYVNTSLAAIFGTIPTDLLGMNWLEVFAEEDRGFLRGLALTALTGVPVRT
TAKITAQRSGERTLDISLVPVTSRDMSVSFIGTVQDVTEQVANEARLTFEVDHDALTGLA
NRRRLEGDITDRLGKLTAATLGSSMIGFCDIDNFKLINDTLGHLAGDRVLIEVANRLSSS
GFAAYRFAGDEFVVLIDDDDRSVEELEELLSKTIFDAIAVGTALLNVHASVGVAMIEAGD
TASEVIRKADRAMYDRKQMRAC
>A0A1V5VLY1|diguanylate cyclase|EC 2.7.7.65|Elusimicrobia bacterium ADurb.Bin231|TrEMBL
MRKLMGRLKITFKTLIVVGGFAVLIFLFALDRLTGLEPSFTISYILPAFLIAWFMGRGTG
IIISMISAILATILTTIAIFYEINPGDLTVALYDDVAGSWNFIARFGFVLVLTYVLLAIR
GALEYERDFSRTDYLTGIPNRRYFFEMADIEIKRFKRYTRPFTVAYIDIDYFKNINDTLG
HTAGDDILKTVTAIIKNSIRTIDLFARIGGDEFAILFPETDEAVCKTVIERMRNNFSTDI
PSAYGKITLSIGVVTFRITPYDADDMLNQADRVMYEVKKSGRNNVKYKTIAAGDSRSTGA
DTKDGSA
>A0A156MR00|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAAAEVINAHEKRFAYWSWNPEDNNDTLGALVSRWLFPVPVAQPIMHNGLTIGE
IRLTARDSLISHFIWTSFAVLTGCILFAAVVALVITQSLHRGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMMEFGDKRHQ
SYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENT
SVEALLERADRNMYQVKNQRTKTIS
>A0A5P9EFL6|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MNTPKHPDLGAALEHSRSGLRDNHRRTLARLLFFVTGSALVVFAVLQFLNGFPWVSAIEL
LASGLLFFGAQRLKTTPHLQQWIYAYLVAIFSFFIVIMLLPDASIAAFVWVLMMPVLAYL
LLGKCEGMILSVPFMIVGLVVYYFFLETVGTAHGMIDLLNMVLCGVLMQVFMHMYEERRE
EAEQRLVDMAQTDALTGLANRANFHSTLARTIAECERNGSGFALVVMDIDHFKLVNDTLG
HDAGDHVLRNIGQCLAERLRTTDSVGRLGGEEFGLILRDVKPADAFELMDELRERIAGRE
LRYGEAGIRVTASFGIAQWPDHGQDAETLFCVADRCLYTGKRAGRNRVAPAGPIHSDRSQ
KTVAGGTV
>A0A7D6YZF2|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAAAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGLTIGEIRLTARDSLISHFIWTSFAVLTGCILFAAVVALVITQYL
HRGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENTSVEALLERADRNMYQVKNQRTKTIS
>A0A155ZDD8|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MMNDETYYNTKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWAFVWPHFAWQLSCRAASPHQQEEFNLKIDAIIAGLWIGVMGMSALPSA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPLVGRVAVFNPDLVEWSLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVYNRRHWEMLLRNEFEHCRRDRCTATI
LLIDIDHFKNINDTWGHAVGDEAIIAITRQLQMSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHERLETLSLPCAPKEALRISVGVAPWGPQFAHYREWLKAADVALYRAKNAGR
SRTEVAA
>A0A5P9EFV7|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MKEFIIQRYRPDLSGPVIQPTLLRVDDDGRIAHVDRHAEAMFGYDAGALIRQPVQRILAS
RQDDPFAPAHRHHLDNGQTVLVTFRHKDGFFFTAILGLRMEMRDSDQAANATISLKDSGD
MDGRLLRLAEQGAGFGLWELDMTSNEISWSEGMYRLLELRPGTELSPEQALFYCQVGQNR
VRALFRRCMRTGRPFSMELSVLTSRQRLQRVILSGRALKSGGRIQKLGGVMVNHSEAMLH
DHARQQAQRILEATANATPDLVVAVDTSLNLLHFNAPWAEQFRNAFGAEPRPGDNLKTLL
ADFTNERRMIERLWQRAFDREHFVAEMPLNRQGEGLPVYEFHFQNIQGLQGEVVGAVHVA
KDISNRVQHSGSGDYRMRHDPVTGLMNRRSFVEHLERAMKHKRKRQSMDGLLLLDLDSFE
QFNEQAGSGTCDRYLRELAGMLGLRVRQRDALARLSGDTFALFIENCPEPRARKIAEEIR
EQIAQFQFEWQGRQLQTTASGGLLILGTDAPLQPEQLLTQAADLCHTAKTSGRNRIHTTQ
ALPGELANRGTDRQLEQLHQALDNGQLILEFQSLKPVASVTWGDHIEILCRIPGTGDDSP
LLPEQFLPVAERFDLAKRLDRQVIRQTLQWLSQHRLLEPRLKYCGFNLSLATILDDTFAD
FMEQQVRQTPFQARCFCLEIRESHATQYPDEVAVLCDALHRAGCRVALEGAGASVESYSL
AANLPVDIIKLDRRIMNDLERDPVQQIMVDALHRIAETAGKETVATFIENDETLRKVRTL
GIHFGQGYRLSRPRPLDELKPAEVELSTGRIGG
>A0A1S7QRR6|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense RV3|TrEMBL
MFTVLECVVVQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTAFSAVLAVFGFWLALTSRSQAAYSPAIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWAFFLLAFFLFRRLGSWQRIAAPAGSAI
FAICALHFTAMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSTTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGREEASLVGQNPDDLFKAIDGQPAYLP
RHAPVEAVHERAGQAQIFELGVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDEEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTTRHTRAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGKDDESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRRAT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVSATTRKKHSV
>A0A7U8W275|diguanylate cyclase|EC 2.7.7.65|Escherichia coli FVEC1412|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKISQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A380BGS3|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MDFGLATEFYPEDYQYLSDQPHAIRPKMDSLQAVQRLHASLDPRTVFACYGKLLQQYLPV
QGVQLRLKGHQFHWGRTSQSTVSRELVSKLGTAKLRYRLQRVLSPVEQAELEQIEALLSQ
PLFNAIAYSQMSEQAMFDSLTELGNRHYFGQCIRTSLARAGRAHSPISLVVLDLDNFKQL
NDSLGHKFGDRVLTQFGKLLKCGIRNADQAFRIGGDEFVVLVEGNLESAVRMSERLLEML
ANETLFHRHGIACSIGIAAWSAGVNQDQLFEQADRALYRAKAAGRNRYCIATRD
>A0A6I2ISF7|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MKNIQPLNYDIIKNEWQLLINNTNAATHQTLMSLSDEEVRQLVDAYYQYMLQDEKAKLFL
STTQVEERLSASMNNWLRKVLGSSCEDLSELIAHQRKVGEVHARIGLPIDLVARGARKLK
YELFQLLLNKPQISAKEISDAIFFSGMAIDSAIEVMTIAFTPSHQKMMHDQEHFRLLTVY
DDMNVERERQLGALKDWENQFIYNIATELPFEERVLLSDSEFGLWFAHKGQHIFRQPDLI
KKIDSLIQKIDRVITTEFANESSGAFSRIHLLRMLRQDVEQVNMILSSIFEEIVKSENGK
DPMTKLLTRRFIPTIMGREIGLSISSGKPFTIALLDIDYFKKINDNYGHAVGDNTLKNIA
TWLHEYVRSSDYVFRYGGEEFMLLLVETTLSQAQVLTERLRNHIASQMIEVDVDTSFNVT
ISAGLVEFDNHPDYQRLINKADQMLYQAKNNGRNCIESYPFGMNNSL
>V1HV80|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica serovar 6,14,25:z10:1,(2),7 str. 1121|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4U1G676|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6I2IPE9|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MFLIIMKDEYSSGRWLPGGFMDSSTYLDEDRHRSARRFARRLYIPRIIGLATGFFCVSSV
LVMQPVSGWWWLLLVAYSFIWPHFAWQTADRASDPARAEIRNLMVDSLMGGVWIAVMGLN
ALPSALILAMLCMNNVGCGGLKLFLGGLGVIVLSCLLTLGLSLIPLNLQTMPSQVWICLP
LLLIYPTYFGLVSYRTALKLSEHKRRLMHMSTRDGMTGVYNRRHWEHLLHGEYDNCQRYQ
RSATLLLIDIDYFKSINDSYGHDVGDEAILALTEHLQLTLRITDVIGRFGGDEFGVIMSG
TAQESAIQAMARVREYLEEFRIPHAPRISLRISVGVAEFDKSMVNYREWLKAADVALYKA
KNLGRSRTEVADIAA
>A0A8F6TP57|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sanguinis|TrEMBL
MNRIRLGNGQCRMIIDGGNAQERRAGSDPVGILDASHEAIEFLDRHRLARTTTSYALALQ
TILHPYGPLGGEVSRRTDGGIRLTEDDVRELMPLVREHEVADLGLGRIQMEQDLGEQAET
LEALTSDARAITSDFSEQVTALSHAHRSNDFGPDTRAIATLLEQLIARISKTERDLEELA
GNIAGLRSRMEPGAADDRIDQLTGVTSRTGAHAMIEGLTNEPHGYVLAACSLDDLEGINE
RYGRSVADNVLRAFVATLRQSCEGTEIVRWQGNLFLVVLRGRPLSTLAGMMEDARAAMRE
RTLKLRGTGEPIGAVTMSGGVAVGVGVPLEDTLARADMLRDLASGGLGNRILSRA
>A0A174ZA75|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] siraeum|TrEMBL
MNKKSDTVNSELRDKLFIVLALTGCVSNIAGFTANAVIFGFTSQTLFCAACALVIIVSSL
VGFLTGRTYVATFIILLVLGFVEFPMLYISYGASTAVYMLVAEIGIITFMKPVHRVIMGA
AVFVADIAAFVVRSKFPQLNMVNDNKELDTLFSFIIAFIGIMVAVAIVIVQFERQAKQLS
KMGEELTLAVNTDPLTEIRNRRYLIKYLENQLSQDDKKKHCAVLIDLDLFKSVNDTYGHV
FGDDVLKHFAYAVKTNIGENDLIARFGGEEFMILFDTDNIEAVMTVMKRISKSYSEFSEK
EKGKEFTFSAGVAVYGSSNSITEIFTTADKRLYKAKAAGRNKIMID
>A0A518CSJ4|diguanylate cyclase|EC 2.7.7.65|Polystyrenella longa|TrEMBL
MTSQETQTSSVASADSNQMVSPEIAIDRTNANVAVRRSGTSSELVTLFHLASLSGENSEQ
KERRRLGIGDDNKPSEGNQENQVSKSLLSVLLSALRSYDPYIYLHSQRVALISTKIASKL
GWNEAQQREMEVAALLHDFGKISVPQHILNKPGRLNPIERELMSRHLFNASCLLQAFKIP
LSIITILVEAERAQIIKKLLQNNSLSNTSLGARILTVADAYDSLRSSQVYRSGKSHADAI
QILFEQSPARFDGAVVSALQSWVDKDAAAQMIYKEGATNEIPAGQLKETRESILAERNIH
QIMQYLASLDEHYSGFYLVDRKMDIVMWSQGMQQLTGRSANEMIHIDWNPELLTYYSEKR
KKIGLEDQALLLAHSSKKSVLSTYYLMNESELLDEFEVQSIPIVGEKNQILGVLEILFNQ
KTVEKSGGDEMQQLKLAASRDALTKIANRGELERQLQSMFQLFDKKGKKEIFSAIFLDVD
YFKSINDSHGHAVGDRVLIDLARLLEAETYSGEVVGRYGGEEFVVLCPNTDFEMAIQKAN
RFRLAIEHASVGGLPRATVTSSFGVAQIETGDVVHDVVRRADKALYQAKETGRNRVCSLT
RLEQSEEVVEGKPAEKISVNAMEHIQTITACTSADMIVYKLKAFLEENHAVLKEVDSEQV
LMKVGRSGMLSGWGKSPERQPVQMRLEFDSQSRKQGGHKVSEIQVTVTPAVKPPSAEKFQ
IRARQIIRSLRAYLGSI
>A0A0H3EE16|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bifidum (strain PRL2010)|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSAAASGEEGLELFTKGGIDLVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
GAVDDDIPLVCGDISMQVGQHQVTVRGESVFFPLKEFELLEYLMQNKGRVMTRHQLIDRI
WGSDYVGDTKTLDVHVKRVRSKIEEDPAHPQYLTTVRGLGYKIDSPQQ
>A0A7Z9E128|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MEKIKVGILYSLSGTMAMSATPLLEATLMAIAEINAQGGILGYEIEPVIEDGASNISVFE
DKARKLLEIDQVATVFGCWTSMARKAVKPIFEQFNILLWYPLQYEGLESSPNIFYSGSCL
NQQIQPVISWSLENLGKRFYLLGSDYVFPRTANKLVKSLLKHEGGTVVGEHYFPCGDKNF
TDIIHEIQDLKPDIIFNTLNGDSNFYFYNSYYHAGIKPSDLPIMAMSISESEVQSIGKAS
IGHYAGWSYFQSLNTPNNQEFVNNFKALYGQERVTSDPIEAAYFQVYLWKQSVENAKSFE
TDAVRQAAYHQIFHAPGGLVKIEPNHHLCKHCYIGRVTEVKQFEIIWKSPNLIKPLPWLG
VEELKNFPQADLVIDMLAELSQGIQYSCLLEQNSLSLQITMAKLQLEIEERQRIEIALQE
VNKELKYMAITDSLTKLSNRYWFNECLKSLWHQNLQNKTPLALILCDIDYFKNYNDTYGH
QMGDYCLQQVAQAIKKAVRNTCDIVARYGGEEFAVILPRTALFDASQVATRINLEVQQLE
IPHLNSLVEKYVTLSLGVASQIPRLNSSPELLISEADKALYQAKHNGKNQWCLHYV
>A0A4U6HKK2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls714|TrEMBL
MSKQSQHVLVTLPHPLLRMASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGESLSFTYTTINIIEAIVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPVLGGLLLWLLLPKETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETVITLLVTLTFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSMMLAADPSLLYIPKPNLMTSLPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLNNDL
EQLDMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAKNVIRDSLAARAPFKLEFRIAVKDGVRHIRSLANRVLNKDGEVERFLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWEGRLHRIGASAGITLIDEKNHVASDVMSQADIACYAAKNSGRGRV
CVYEPQQSEAHAARSQLSLDEQRHTITHNPMLIIARGVASPRIPETFSFWLLSLRLGTAE
GEIIEEHAFRAGLVDPTLNQALDRRVFTEFFQSAAPAVASKGLSIALPLSAAGLLNTELV
DELLGQLQRSPLPPRLLHLTVPSNVIKTNPTQAISTLHRLRQCGCRIILSHVGRDLDLFD
NLKYHMVDYLLLDSELSASVHGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A679JJA6|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MHLDVPSLMLPLGLGYLLFAWQLVLVRRRLAADRALALWTKGCVFLLAGMVGLLSRLVLP
EWLSIVVGNPLVLCGMLYFTQAVYLLVGKGPVPRWITALVVASALATPVLLAWPMSVRSM
IFSVVLMLLSGALSLHVFRHAWHAESTMRAVALTMLMLSVAHALRALQAGLVPDQYLNFF
QSSLGQGIVVLLAFLALLGSGVGFVMASLERTAKNMEFLASHDALTGCLNRRSFDPLFSH
EVARSRRSAEPLALLLLDLDHFKQVNDLHGHRSGDLVLQAFARRVQGRLRSADVFARLGG
EEFAVLLPSTDLAGAQHVADALCRAVAENPAQLPGGRPFALTVSLGLAMFEPGPANAGPA
ERGAHSGATAQVSPELLYMRADQALYEAKRQGRNRVAVWREQPLAFEDLVVSA
>A0A1V5QBE7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MRILRTIRNYFFYCGIEKDEYNAIKKEAYVSNFEVWKILHFLMAVLFAALFISSLFTDLM
RVNGPAYLAGFGYSLLIIGLFFMMKKDSIIPQFLIYLTISLLFIFGIVLSVRNPDVPAVS
FIAFLLITPMFMIDKPFFMAFELSAASAVFLIWTYPVKPYDVWIVDLANIIPFTIIGIFL
NVIANSLRIKEFVLTRMLNIQKDTDDLTGLKNKGAIIREIDKFLSDDHTRKGIMYVMDID
HFKVINDTCGHDVGDEVIAQFGRFLDELFAGDEIVGRFGGDEFIVFIRDTDDRDIACRIA
EDIVKGCAGKVVYGDGSDKVSASIGIAIYQGEEKDYSELFKRADSALYEAKADAVIRYHI
SEG
>A0A1V5PIX1|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MRDPSTGVEEDHMSIFRLLTDLGRRLVNADRASLWRVDNEAHTIWTLSATDEGRIVIPEG
SGMVGKALAEGKTLVTNDPYHDPFFNADVDKSTGYVTKSILVMPVTNSRGEYIGAYQVIN
KLDGDGKFNSRRDCKRLSLAAFICSLTLESELFLADAESDRLTKVRNRVGFYHDFNMRYG
TGVDRRNDAKPGSMIMCDIDHFKLVNDTYGHNAGDAVLRHVSRMLVETSRKTDTVYRWGG
EEFVVLLDETDIFGAARAAEKIRAAIEESTCIFEGTAIQVTVSFGCCVVNPNMTAEENIA
VADKRLYNAKESGRNRVVMEG
>A0A1B1NU00|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MSNFVGRHLEEMADIRATRKCKLVRLCSLLSICVLTGYGFAYFANHENVFATINFVCCVV
LALNLWHLHYHRSLNYSDLILTGVLMLQGVILLLYSERFPDRLMWIFPIIAATILINEFR
TGLLFSVSFCALAIAASLFTDAVFTQLDTSHERFILSLIVICLICNTASFYYSKMLNYIQ
SLYREGIEDLAYLDQLTGLANRWSFEHWATKKLAEIIHLPSTTALVFLDIDDFKEINDTY
GHEVGDRVLQQFSKRLKNNIRTRDRDSNKHDYSIARFAGDEFVILLYDVRSKQDLEGILH
RICHLFQDSYSGSKQVSSLTVSVGVALYPQDADNLHELTRCADKAMYAAKHKGKNQFQYY
HGDTLCSLQDIPTLTEGNVRKINNA
>A0A0B7MRM9|diguanylate cyclase|EC 2.7.7.65|Syntrophaceticus schinkii|TrEMBL
MDYIMWGSIFLELALSVSGDQELDNLVKKAASTFLKKLNCTHVSVLQRNNNRLEAIYVLP
RVTLKNPAYDDLVGEFERKIQQDKDENVIVIEKDVHYYGFPLRNFGLLLLGSNVPFQDLF
LKELLPITTMLAQNCFAKFDADMKRRATEAEFKKERHLLREIIDTIPDLIIYKDPKGVYK
VANKATEKYFSLLPEQLIGCTDWDILNKVEASKYREDDQKVMASGRVQRYDRPIQRHDGC
LVPFETIKVPIYGMEGRCIGTVTVSRDISERVEADKKIYTEKQWREILFKNSTNAIVRVD
CNYCIEEINYSFTRLFGHKMKEIKGKDLNSVLMGDTCTAGRYYKQILLSGKEIALEGTYY
TKEGLPVEVIVKGFPIIIDGEMLGAYMVYIDITERKRHEEQLKYLSSHDQLTGFYNRSFL
EEEMKRLDTPRQLPLSIIIGDLNSLKLINDVFGHQKGDTLLIKAAEIIRGSCRQEDLIAR
WGGDEFVILLPQTNIKIAEDIILRIKEKCDSQKDEPIQVSIALGCAAKNSAEIIIWKVLE
EAEGRMYSNKLLHAKTYRDTILLSLKAALMEKSMETEEHAERLKEMCRKIGEGMGLSIQQ
LNTLELLAVLHDIGKVAIEEGILMNPGSLTEEEWGKMRKHCEIGYRIAQSAPELSHIAEY
ILSHHERWDGKGYPQGLKGEEIPLLSRILAVADAFDAMIHDRPYRKAMSREKAMAELKRN
AGTQFDPDVVGVATKLDTFRNVKIS
>A0A0S3PQA8|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MMLAPNAVFEPDTESARLEALERYDILDSVPEESFDRVTRLVQRLFGVPISNITFIDGHR
QYFKSSAGMVCDDTDRGPALCYAAIRADAPLVLPDTLKDPRFADNQFVIGEPHVRFYAGA
PLRSDDGYPIGTLCAIDTKPRDFSEADLATLKDLAQIVESELNLRRLASTDSLTGLLSRR
SFHSEANRIINLGQRYGTRAACIAIDLDHFKSINDRFGHAKGDEVLRRTTQACAKALRKA
DILGRIGGEEFAVMLPHTDPEASREVVEKLRAAIANVMFDYEDEPFTVTASFGLAQFDRS
VKDIDELLRRADIALYEAKKAGRNCYVEWQKPTEGPAPSIPRRVLKAGQISFNAGNSTID
CTVRQLSDTGARIEVFDSVGVPQQFKLRIPGDSFSKSCSIVNRESRSLDVAFA
>A0A381IDB6|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MDDALIAKVNFLKARKYADLLKDMQVSSLCNIKIGECECSFENYECSMEYFNEVISNKKY
RNVNIIQKYRASNNITKILIKTRNYPVAINNLAKSEVYLEKIKNHSLKEVEKFDLFISLA
MYYAKSNEKSFEQSICYLDRAKNILNMIKNIEEYIIYDLEIIYHQAKIYYIFGYYDNALN
TNKKLLEKSKNAKNYNYVKLAYKSIYLCFEKIQNYEMSMKYFKMYYELKMMYIKARNRNY
IDSLNYRHEYIEKEINNMRKVKLDLDKKKYVDHLTSAYNRTFLNDFLEKQEVSEYCTAFM
IDVDYFKEYNDTYGHYNGDIALKNITIIIKKYLKKDMLMIRYGGEEFLILSVCKDYKKSK
IFGRKLCRIVKKFLNNNLTVSIGIDTCKNSSIDIKEIIENADKALYKAKESGRNRCLHYH
DFKNF
>A0A0S3PX21|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MLFRELLEDFLQCLGLISLISIGYGFFVRLRPVWIGQLATGASIAAAAAISMAVPVVIDG
LFFDLRHVFVLISMMYGGPVGLLLTVLVTAAFRAWTAGPAMAAGLVGIGLSAGASIVLAH
YVPKVSVSERALFLLGASFISLLSLFLLPGSMLTTAINKVVVPLTVANFLGVSIAVLLLE
IKRTRWTHEVQLANDARFDLLTGIRNRRVFDRVAPRLVERSVRQQKPVGVLMLDIDRFKS
INDTYGHHAGDEVLKRVAHLLDDAARAGDLVARFGGEEFAIVLPGANEAVSRSIADRYRS
VIQSASIVVDGKVIPVTASIGFYVVESIEDLEKILRKADSALYRAKTNGRNRTEGWQPNQ
LSLAYGQPIIRR
>A0A1Y5SL56|diguanylate cyclase|EC 2.7.7.65|Pacificibacter marinus|TrEMBL
MQLNKTSLDLLMPMHVVVDEAGRICGIGPTLRKLRPEAQLLGARFLDVFDLRDDGRDKGD
MILPIDKKLYLTFKAGIQTRLKGVATPMHKGAGLLVNLSFGISVVEAVRDYRLTAGDFAP
TDLTIEMLYLVEAKTAVMEETKQLNARLQGAKVAAEEQAFTDTLTGLKNRRAMDHVLERM
IRSHSPFALMHLDLDYFKDVNDTHGHAAGDTVLQRVANLLVEETRSEDLVARVGGDEFIL
VFHKMTNQDQLMKVAQRIISQLEIPIPFNGAVCRISGSIGVTITDLYETIDVDQMVQDAD
TALYASKHEGRARANMFTSGMALDDMSDLPRVAERR
>A0A1Y5RUJ3|diguanylate cyclase|EC 2.7.7.65|Pacificibacter marinus|TrEMBL
MSGKLKRYCAPDHAGTVGFGPALAALQCQKMLTYIGITSAISVVISILFAQNFLPTSTVV
LFPHGLTLTCLLLLACTAFAKPKLLRLSIFGLCILLAGLRWIEILAWPDIPFSLFLEQKM
KAVMPSETAMGANTAMSVVFISIGAVLRHRSPTFAFVLLLAGLAFPSISAIGYTYGHHGL
YGVMSPATTIVLIALGGAEVLNFVRSPLLLPLLTTSSWARMARLQLVCVVIGAWVIGVFL
NHSGSGATSEAVVGWVIWLFLGTMLVAGARFERIDRERRAFERELERRANFDPLTGLWNR
RAVRDLPWFNAVKRADQRVEKDDHVGVILADVDMFKRINDISGHEQGDRVLRDISRVLRE
RVRGVDVVARWGGEEFLVLLPNITVEKTMEMAQILRVAVATSVSWSNAGQSEPVTLSMGV
TVTNENAEKTLESAIQNADTALYSAKSQGRNQVMLFGDQPSRPKEDLVVKFASNRAIH
>H8FR47|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MARPGRVLLVDNSRTFSMVIAAALTDRLEIEVTIADSLGAAARVLDDETGCDNVVLVISG
LVLPDAKESEIVAFFTGRDLPLVVLTGTFDTASRERILSHPVIDYVLKDNPSSIDYVVWL
VRRIWRNRDMTALVVDHTPSDRAMLSGLLHLYGFTVLEAEDGTQGLTIAETTPRLDLVVT
DYEMPGLDGIQLVRRLRIRHPRDRLAIIGLSSSTGAISAQFIKNGANDYLNKAFQPEELF
CRIAQNVENIENIASLHALATTDPLTGLRNRRSFFELAQSRFRTLTQSGRPVAVAMIDVD
HFKRINDGWGHDCGDRVLIELARVLAETTLDGDVVGRLGGEEFCLLAADLDETSDFFDSL
RRTVAALSPRFGDETLHVTISIGVCVRAGDGRADSLRALLTAADRALYNAKRLGRNRVEY
A
>A0A2Z4UIX3|diguanylate cyclase|EC 2.7.7.65|Rhodobiaceae bacterium|TrEMBL
MGQQIPNERAANAFSESIHPVIDTMEMRLRCELLREAQESVDPDTVVVKALEYAAEAEQR
IAELNARVRTLESLAKTDELTGLLNRRGFYDAVRRELQQSARHKETGVLAYIDLDEFKPI
NDTLGHAAGDEVLRAVGRQLGTNIRATDFAARLGGDEFAVLFVRAEHIPARKRARVMLEE
LNSLTVPWKRKKVQVRASMGLANYTGETAFEELLAQSDRAMYREKRKATESRSAAATR
>A0A6N2TR24|diguanylate cyclase|EC 2.7.7.65|Clostridium innocuum|TrEMBL
MKRSLFKKHQLWYVAGFLIINLAACIIIGNHAYRQIQADMNAHALQSQEEVQSVMDDYRH
SFQLFTTMLEREVEAEPKPAVIWKYLKKLDKQLQAIEGDTFDGLYMYYRNSYLYSWDTPY
EQYEKSGYDATTRPWYRNAVDAKGEIVFTPPYMSFANHYILSTISQLQPDQKTVFAYDIK
MGNIQKLIASLQAYDKEQLIIFDKKGTIIGSSEEDYLGGNLMQSTEENREQLTEANNKLK
QADSSISKEDRKKLEDEASYAQAFYDFQNSFSTDFNSLLKDNGMQLVDYQNQKYFGLIQQ
GNEFDYLILVPVYSMLSATLQIWLIPLLILEIILIYVLSQISRELKNRELKGAYVELGQT
QKRLEIALQAAQKAAAIDELTGMMNMKSFRSTVKHHIQGMEEDENGILIMIDGDHFKSVN
DQYGHSVGDEVIRLTAQMIVGRIRTVDYASRLHGDEFAIFVSNTRDYCVAEKIMEDINLS
LAKEAQKRNMPAITLSSGAIIACPNDNYMELIKAADEALYRAKETHNGAFRQAEER
>A0A655BV31|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPAD
SAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAG
RNRTEVAA
>A0A8G0HZL8|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. sptzw28|TrEMBL
MLFILSFSFVFFGQFLLHVLPDESSLFAVNIMLAAAFLSMTFGLYFSRALSKSTYRPFLF
HCCASVPLLGIAVLAARSPLLDFDVIHGPYWRTIHYSGLFSIVIFGLLIYTVSGFLSQSI
AAYRRAKSNKVSVQERTRLRLILKGAVIANIWMALSFLFMGTLEAWNPFLPTVAFSSYSV
IIFLLFIRYATVNYDFLSTTGRRYQILFDLSPNGIVLLDELNRIVEANPALLRLIGVQNF
QESHWKRERISTFVTIEGDGTTYKQLTDALANKEIIQLELQIRNHINEVYIIEINTRYME
VEGRIWTYMTTKDVTMQNENERKLSFLAYHDPLTGLLNRRRFYEMLDLAIGQTVTANRVI
AVISIDLDRFKCVNDTLGHSAGDELLQTVAERLLSCSPSDACIARMGGDEFVILLQDISP
STEWLTDYADRLNVQLGQPVLLDNNPYRISASIGIDIVTETDADAKTVLTNADKAMYAAK
QNGRNQYCFFDAEIA
>A0A1V6AHV9|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MTNEIKRKKAISIKSVVVIIYSILVIIAFTVIIYALFNTSMYAARKEADVACSNLNNDIL
NIIQSSIDTTNHINKVYGDMISSRIISINDKLSRDALLINFLKNHSDYISAFAYIDAKNN
LYAALYQNNMDIQVISENEMVISQKTEFFNWLILARATNKAMILPVSASYWSPAPTIKSF
YPISDSNGLFVGILYIEIDLMSVYEKISSSVVSNTDVIYIIDKDTDKVIFSVNSGLPLSD
ASIKEYKINKQYLTYITTSENAFSSGGLIRGNYYTFKEYSHDMINWVIATSVPHRFYLDS
FRENMSILMLFTVLSFTISLVLYHLLSDKLIKPLGNLVDYASDISNGNLDVRVPVFQDNE
IGKLSYAFNQMTKRLKNLVSNLEKTVDERTDKLTFANEQLKESKEQLQIILNSTAEAIYG
VDLDGICTFCNISCLKILGYESEDKLLGKRMHDLLFDTSKNPHSSCRIVEYIKKGHILHE
DNGEFLKADGSSIYVEFHSYPQYKNNKVIGAVVTFLDISQKKSNIEQIRYLSYHDVLTGL
PNRRKFEVITEQIDISNNIPYSVIYADINNLKMTNDIFGHDTGDNLIVKAAQIIKNNVNE
DAFIARIGGDEFFILLSKTDYNQALSILNNIKEEIHNTKIAAIMCSISIGAETITDDKTT
IEQAISNAENKMYREKVMNRKSNNTNLLKDLINTLHERSPREITHSENVSALSEKIAIAM
KLSEPMVKRIKLAGYMHDIGKIVLNEAILKKDYYSDEEREQFHLHPVHGYRILNLFDDTL
DIAEGVYCHHEKWDGTGYPKGLKETEIPLIARIIAVAEAYDALVNRKNDFDLSKEEALKE
IKDASGISLDPYIADLFVDIM
>A0A8B4TW97|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVSPLFTVVRFTLPCALIVACSGLMLLW
HWKWPQAKINIPAISLLFGMLWAWHVVAKAMLLTPPHFNYLVIALLSILFIGTIAFSNNI
TAFTLHSLPTFLACLIMAEGEQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMQ
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSKETAWQAAERIRQRVYDLKIPHM
FNESVATNVTLSIGLTPLIDDNIEQALARADGALYEAKNKGRNIILAS
>A0A8I1ZVQ6|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium|TrEMBL
MKNSTRIDELKATGRLPSPTGVALAVLRLTQDPNVTVEQLADVLKCDPALSGRILKHANT
SAAYDGCPAVSVTEAAIRIGVYRSSQIALGFSLLSRYRNNPCRKFDYESFWSYSLATAVC
AQGLSRAIASANEGEAFSMGLLCQIGRLALATIHPDRYSAVLDAAGASQEAQLCGLEREE
FALDHNELTAAMLEDWGLPAVFVEAARCQEDPAGSGLDRASLDFRLATLLHMARHMADIC
RAEEAFRPPLRSALRAHAEEMNLDPEAAAEMLETAAGEWRRISRLLGIPTTKADDEKLAL
GGQGGERPDPEPKDHERMRILIVDDDPALLDFIGALLRHEGHEVEAASDAETALRRALEA
NPHFIVTDWVMPGMTGIQLCKALRQSEQTKSIYVIMLTACEDESHLVEAFDAGADDYVVK
PFNPRAFLARVRAARRIVNLQEQVARDKEEIKHYAAELSVANRKLERAALTDPLTGLANR
RYALDRLEQEWNTAVRYARPIACMIVDIDHFKAVNDTHGHDVGDRVLQQTAQLLRENVRK
SDVVCRFGGEEFLVICKDTNLQGVRTVAEHIRTKVEGTPFEVAGVTGYVKVSIGVAVRST
AAASTKLLLKAADGALYAAKARGRNRTCVAQ
>A0A7H4N1V5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNHVAVNWVRYGLLLWIAGGTFDLMDEIFHQPRWMGYYCEDLLRLSGMLLSAVGVYKIIE
RINLLYVDARSQSLKDELTQLPNRRFFIDTIREKEGRRLALMIVDIDYFKKINDTWGHLV
GDEVLFALGKQLAKLTSDKVLPSRIGGEEFAIIVDGLSAQEVDELAQSILQNARAILINH
DNPLSISIGVGLRHKDEPQNLFIKKVDDALYKAKNNGRGRVEWAA
>A0A5Y2QNW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V6AFK2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MLDDGTLLRLFVSQSFIVYFILLISPLKKPERRSIILVIIGSFIIMIFNALLIYYIGISF
YIRFYFLTLTLPYIILGLYFSVIKGAKFIFVIFSTQLIANFAILNGLLASYIFYGENTPL
IDTAARVLTYLIILPVVIKFIRPTYRKMLESIKKGWWMLNSALIISYILTYFILFVPDAV
FNRPVYFYHAYIGMILSLFIYAIIFYLFIEIQNKTTIEHDKQLLSTQVLSLKKATDEITS
IAYKDTLTGLNNRYLLYKQINKYIQNKQEFLVIFIDLDNLKVINDTYDHSTGDSYLKQFA
KALLKVVSNQVDVYRFAGDEFICLITNAQAGFDCNHFREAIAKEMTMDIPYLGISIGLAH
YPYDELDPDDLIKLADRNMYLEKRSKRKANPIV
>A0A7H4MW09|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITALRLG
>A0A162TD02|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MEYLEKKSVHRNSIFDSIKKEITFELDSSNLIIDISHNVINILGFLSDEMIGRNIFDFIE
VKESYFNLNFLDNIDMFFIHKNRGLVYMELQIKVIEDDRGKILRKYGSMIDISKYKEIER
RKEHFKVVLESAKDIIYRFEIIPEPKFVYISSAVEEVFGYEVEEYYKNYMHVFNTSHPDD
ISILYKKMNNELDYSKPIESRWIHKSGNCVWIEDYVTPVYDNSGKLIAFEGVCRDISYRK
ALEENLSYLTYHDSLTGLKNRAFYDKQIEELNTLSNLPVGVIVCDLDNLKVINDTMGHNK
GDSIIKSVSDLLLGIENNHIFISRIGGDEFVILVKNTSEFEIEELGRNINLLIKKHNSKN
RECPIQLSIGYAFADRSVGKMEEIFKIADKNMYANKLHKNKRDRNAIEVTYNYTTIAIE
>A0A6S6WMS4|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MRSKVSWLFSAVAIIYFVIAFYAADELQSLLESRASSLAKEKTLVSVSSAKSTLESSLYR
DIYLGDSLATVITLNRQFAMDNWLDLGATLISKANNVRNVGVAPDDVISKNYPAAGNERA
IGFNLRESATQYPSVLEARELQDVFLAGPFELVQGGKALAGRYPIFSDSPFNTNYWGTVS
VIIDFDRLIESTGILDVQGATLAMRGVDGKGDEGEVFFGPAEVFNAPDFVTRVSIPNGEW
VLAGNYTSVIPQALHSPYVLVKWTVFSALALVFLSAWFMWRGYRVHRLHAYQDELTGIAN
RRYAMRRLDELMSNERRSDFTVLSIDLNRFKRINDNLGHHAGDLLLQLVSDEIQRAIRGS
DIVARMGGDEFLVLLHRLKDPVKVNKVIEKIREQVEHSSICINEQVIHPSLSIGFATKTK
AITCVRELLKIADERMYEDKAQRSTH
>A0A161Y447|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MKYAMLFILLIVIIIVAIYQLFIYKLKKDYNLKLLRLESKLADVKSTNILRELLEISYEK
ESIGKASKKIIYILLNNFDINFCTVFLNTGNKLTACASNAGSKDIMKELGDYVNNLSETV
MGVGGKKLYTECGTLSYNTAADRDINFSFFIPLKVNGNMIGALLIENVNYDDRNNDMGVE
FFKVVIDTISITLQNLIYYDKIVHMATRDALTKMYNRRQMEKVLTEYMAEEKVFSVAMMD
IDHFKKFNDTYGHAFGDLVLIEVSKFMKKQVTGYGEVFRYGGEEFLICFNNLNSEQAFEK
LDNIRKGIEALTITNENNVSSHVTASFGIAEYPKNKAKDTTILKEFADQALYYSKEHGRN
QVTIYNDIS
>A0A1Z5I122|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MTMTTKHHKVSFSIFSAKVFQAKCYSLIALSLLIFSFASHADNIASINTLSNVTKMLQDK
HGFIWLSSQQGLTRLDGSNNITFSLNNQEWPLPYSWINDISLIDDKLLIASERDGLWLFD
TNNGVAKKLAVDIPRQSHYHSVWFKDQYYINAPNKLYRFNPSTKTTQLLDDNIAIKHLVH
NKEQLYVANSDGLYQLQDDQLQQILSEPITALTALSDAVIAITANKIYRLSNEGDISSIK
HNEKLYALTKAFASDNFFTVSNAGKISKYNGTSLLPLSHNYGSSTPVRLTSLFHDASGGL
WLISSHGVEQLNETYVTNHKVIFDIPINANEITLFDNEIIIGSYGAGLQNFLKPVFKQDI
NSAFTKNGLKIFDLLEINKDLYIASYDGLWRYDNSTKQVEKLDVVADKLILKLEHKNNLL
YIATNYYGLYIYDLSANKIIKHLDIIDGLPSTEIIDVLPLDSGKLWIASSNNISIYQPTL
NKLITLTTPNKSKVISFVYADNKIFASTLGDGILVFNQQGGLLAQLSKGHSFTEMLLIND
TIWASGKPGLYRISPKNYQVTMIENSQQYSFVSSMLVKDDTLYAIHYSGVLALNLSAKKQ
FNPNVIISKTTISGKAYLLNKTIEIASGNDVITLDLASLDYRPGLAKEYQYRINNNQWQK
INNNQLTLTGLASGRYNIEIMATNSLGQWSDIIAYTEIDVAYPWYWTIELRIFYAVLVLF
IVLLTSWLLFLRTKSIKHIHTLLKDDMRNYGRLMNTLQRNLQLTATSLANNDVEQGKQLI
EKSILVLKDNINSQEPDNLAGKTLALAIPFLADYVQSKYEVKLHFTLDDKVDKLKYELRA
DIYKVIFEAIMSAIFKSEAQNFSLSLKEVKQKLWLTVNSDKNSFSQLNSKINFDLASYTI
RQITTKHQASLNIFANDDGSSQLVISVPLMALN
>A0A1Z5I885|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MNSNSIESNKYKRLHIKGVLLLWLVTCCNLASGQQENLPNPVLSEQLILTHQDDISATLK
LADEIRRFQPLKFQQLMQNLSIKDDFTIEQQHLFNFLKGYGYTFRGELDKAEKQFKSILA
SDASQLTKFRASYTLVHVYAVKKMWYEGLELVATNIKTSTSIENSDYYQAYLITTIIFYK
NMKQYDLSLHYIKELSAQILSPKLDCISKQLALEVKFYLNELKSSDPDTAIAINSCKKTN
DIMVTSIIRVYQAKAYLAEQDVNGALDSLLPYMQELDSSYYPELITGVNNTLAQAYWQAN
DIASSKHYAEKALLSNKNNNNVNQATRTYQLLYQIAKTENNPSSALNFHEKYAELERLYS
DDIKTKNLAFQLAKNKNLVQQNKIDLLNEKNNVLAAEQALAETKIANRHLVLVLLTFIIV
ALVLFALRFWRTHKRVKELAEWDSLTGIFNRGHYTQVTNSALKYCKNAQQDLSLIMFDLD
YFKKVNDCFGHACGDWALKAVTKACKSIGRKNDIFARIGGEEFCIVLPSCNIDVAMLRAE
ACRAAIEDIITDASGCEFTITASFGVTDVKRSGFDLDKLLADADFAAYASKNSGRNRVTL
FEVPANEAEEKLDSSWSYS
>A0A6S6WS20|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MAKSIVYWLALALLVTFSSVASARAETAEDMPPVYYHVDKNGRQSIEQVIDKELNFWDVL
NQRAASFGYTSDTYWFHFNLPAADYDRVMRIAYPLLDNVDIYFVQNNQVIQRTIVGDEQE
FSQRPISSRNFVVPIATRDSVAVYMKVATSSSMRVPISIWQPTKLLSDEQLVTTATALYF
GLIICMIVYNLFSFSLTRDPYFAYYSAYILAIGLLLAGLDGSGYQYLWSNFEWLQSKAIP
IFGSIAFIFASLVASHILQTKERSPKLHRGLQGVMVLAGLSFLASILLPYEWMIQWILIL
AIGAAALLICTGISLWQQGLGYARIYTLALSVLLSTIVINALGYLGLFESFFIQSYLIML
GSAFEIMLLSLILAMRFNENRKERLAAEKRLSSRLEVKVKQRTEELEAVMRKLKEMNKKL
EVKSNEDRLTKLFNRGVLDEDLPLEVRRARRTGYDIAIVMIDIDHFKKVNDKYGHPVGDE
VLVELARLLKVHFRRAGDRIYRYGGEEFVILMPGAQELGCHDKVLAVMDVIRSHSFKTER
GAVKITISAGMSLLNSLPGHVASKHLLEAADKALYEAKNAGRDQIRIARPATDVSDNS
>A0A8F4G9K2|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. PL-2018|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A8A8DH18|diguanylate cyclase|EC 2.7.7.65|Burkholderia seminalis|TrEMBL
MSASTSIEKIADWAGRHYLVVGALGTLMSLAALSISAITLWATRSEVVEHAHETSRNVAA
VLVSEIARTVETSNNALVALAADLGKPAVRHMDAGLRHDLLFQRSAAQYVTGMGVTDRDG
QLIDACCGPSHHWNFSDRDYFKVHRDAPNVGLYVSEAYRARSRGGKESIALSRRIEQPDH
TFNGIAVVAIDLAYFDQLLSRLDVGPHGISAVLRADGTILARNPSLNDHQMVRLRRSNTF
DRMLNQDSGFYAAHSRIDGTLRLYTFQRVPGTPLIAVVAPAEGDVLDGFIRMSWSVGISA
SLLCALFCAVVWLLAFALRDNLRKQTLLTGLSRTDPLTGLHNRRALDFALADQWERLHRN
GHGSLSLLFIDADHFKQYNDRHGHARGDTGLRFLAACIRAHTQRRGDFAARYGGEEFVAV
LPDTDERGAAKVAEAIRREVERNRLDGFDDPVPAFTVSIGCATARAGWPASVDAWSREAD
LALYAAKRDGRNRVRHAPSPRNEQAA
>A0A6I5ABX8|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKAEYSPALLSDAICFSSLVMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A378ZAE0|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MPDAMPAVPSQPSSLSPSPSSSPTTDDTLMFDLAPVSLWLEDFSGVQQLFDTWRAQGVTD
LRAHFKADPAHVSACSQRIRVVKVNRRTLSMFNAPSLDTLVANLPRVFRDDMLKTHIEEL
CQLWDGRTHFTSKTVNYTLDGRRLDVLLHGTVLPGHEDTLARVLISLEDVTELEHVRQRV
TMGEQYARGLFEYSPVSLWVEDFSAIKMLLDDARARGITDFRTFTDVHPEFVERCMTEIH
VLDVNRHTLAMFVAPDKATLLSHLPDVFRDDMRHNFREQLIDLWDNKLFQQREVINYALD
GNEINVHLQFAVLPGHEARWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYAD
ELNRLERKGPYPVTVIVADLNGLKGVNDQLGHAAGDALLRRAGEVLGKATVAPQIAARIG
GDEFALLLPSTDASGGAAMIESIRQLVELNNSFYPGTPLSFSMGTATCEAGERLEAAIQR
ADLLMYEEKRNHYAGTVNGRRALDAVSSGSGDAGT
>A0A6H2H664|diguanylate cyclase|EC 2.7.7.65|Polaromonas vacuolata|TrEMBL
MTFDIFSELPCAVLVTDEHERVVSANPNLNALICNAQNALFPEFMDSLLTRASSIFCQTH
VWPLLRRNGEVHEVFLHLHRPNGSPLPVMTNIKKTLMKDQVVYIWLFFLALERSRFESEL
LEARKRSEQLTSQLQDAHERLRELNAQLEARMVVTEDANRSLTILTNTDSLTGLGNRRAL
ESAVAKLGQESDATFSILMVDIDHFKTVNDTYSHDRGDDVLRDVGQCLQAAARQSDTLVR
YGGEEFALILPNSDAEQSLRVAQRVHEIIATARPGGIALTVSIGAATAKLDKSHDIQPTL
KQADEAVYAAKHQGRNRTVHRGSWNSTSL
>A0A378YY66|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MKRKLLSAASYTGRLRVQNLAVVFVVAVLCCALLTWAWGTYQRTSDADAALDALRATLLA
MEKSSAERGPANAVLGADLPLPNASVVALRNAREATNGCLQELLSALSDDGCEQCNPSLR
AVERARLDLAAASANVDLLVQRPREMRSDAAVRDAVDRMVRVIADFVPVAVSRIDVVARG
APDALHYVILARLAADLREYAGQLGSHFTATLTTGRPLTEADQRVIDRTLGRIDQLREMI
AAHLVEPPDLGPQALAPLNTRYFAAGLHYVATVRTLASQPRRAPLTTAEFANQYVPTMRA
ITDFRDSMLGLAKRKVEAQRERALRMLILTAVVEATLVLVIFMVLRNFRRSVVQPFEAAV
RFVDSLAQGDLDAPLPDERTPPRRPQVRAVFDALRVLRLNAVELVQLRRERARLHGELEM
SADTDPLTRLMNWRAFERQAQALSAIPSQGQVALIKFDIDDFTQINATWGHRVGDDVLRR
VGAVCLNTCQPGDVLARLGADGFIILARVLDDSRAQQFAELLRGRIEATALPLPNGGYLS
LTASFGIAMACPQTGRTVADAANDPVDVSALLSQAERQLHAARQAQRHAVD
>A0A239ZHW7|diguanylate cyclase|EC 2.7.7.65|Clostridium cochlearium|TrEMBL
MVDNENLINMECYNTWSKQQLVKRINELEKLIKNLKDMERNLIEKNKFLQEISMYDCLTK
VYNYRTIMGIIENQTKYSKDREEVFSILMIDIDDFKSINDKFGHVFGDEILVKICNEINK
NVRKDDYVGRYGGEEFIVIFNNTKLDEAVTIAERIRKSIEGLEILPYLKVTISGGVKEYK
NESCREIIESADDFLYRAKRAGKNRICY
>A0A1U3QLN8|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQ
FSDTGPRSMIGRVIVGLCAVGSLGWALRWVVGPWPSLREAVAFVAFADIGIAVACWQDSD
PLAGLVGTVLFTPVGAYVSFFLANRLLVAHVAWCAPMIVALSSRLFAEGTVGAAMTALVK
VTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPL
DGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLVDVAHALTCGTTGTSVVGRSGGEEFLVV
TVCPAAAVAEFAARLREAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACAD
RAMYEAKRDGGDQSRILHADHDSEGRYL
>A0A1T5HWG6|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MSAELITAYRSFNKILKRLPVDKSLADMLSQVIELTEETFNSRQTSIFLYDDNEKKFTPF
INKDSHSICNERFMVNPAQIHFEHICAKNKLIISENITSTNEYREYYSLKTINNFNFCYG
QPILSSQNKILGIIYSHCPHHSSMTDNECELLDMAATVCSISIEKNIKEQELDYLASYDF
LTNIWNRRAFYHQINQAIINIKRKNEYLIIFYLDINKFKMINDKYGHHFGDRILKKYASK
LRKISNDTTGVARLGGDEFIVYSEVSTLVDANIKKREVLSELQQIEIDGVSITASIGSYC
IHSKNINNTNIDSLIHNADMSMYSNKHLSRPC
>A0A5C6ARQ4|diguanylate cyclase|EC 2.7.7.65|Stieleria varia|TrEMBL
MNQYVQEILQNDRIPSPPSVAIRLLDLVSQPDVNVDELTKVLSADPRLSARLIAYCNSPM
VGSKRKIASVPQAVMVLGLRTLRLLSLSFSLMDTQSKSDFDFDDFWRSSLATAVAAKCLG
RRSGQSGDEEFLLGLVLNIGMVGMGVTSPQKLTELLADGKAMSEITIEMENSVFGTNRFE
VGGKLLEKWNFPSAMAQTIGDFNPEQLNPESTRLALGQTLAALLLSTDVSEAQLAQAKTD
ALTLAQIDDVGFRELFDEMVAQWTGYESLFNFDSIAYGSLQELEERAKDSMMKISLGMDS
EIQRMTIERKELEERVMIDVLTNLKNRAAYNIEVSAAFEHHRRNQMSIGVVVIDIDHFKS
VNDTYGHAAGDDVLRAVGRCLATNCRKGDSVYRYGGEEFVAVIHNCEFNSIKAVANRFLT
AIQDLQIETDVHSLKITASSGACWADKANVQSVETLFNHADKLLYKAKVNGRNQMFIDDV
TTLSAAT
>A0A173YD17|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSIIAYLQRLANGVSTAELDVAALPAELRAVGEQLQKTHAILQQERQLLER
NTYIDPLTNLGNRNGFDRHVEQLWRKGDPFTCAYIDIDHLKHCNDRFGHAEGNRYILGIC
RTLSETMEHDEMLFRIGGDEFVLISLSANETELEQRLEQVRAGLIEASSGGKAPMIGSFS
FGCSRVDPLAGDTRRQMTMDADRKMYRYKLMHRVQQPKDDDAPQRPIVDQLPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSLDMWLARVHPEDRDNVRAEL
DMVINGTWHFHYMQYRVMDATGKYVLCDCTGYRLDGTDTEPGMYVGIIINRSLADTTDSV
TGLGDIHALVNAIGEMRRVAREAGFIAIKVDDIAEVNARFGFDAGDRVLAESAACLMDCS
RGKGRLFRSTGPTFVALFDELGPEAIDEIANDIERFLGSPVLIGSLEYQPPIRVATLHLD
GVDRQPVSILNELKALLGKAVQVPGTKLD
>A0A8J7V7U7|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MSPDNKPDERYTRDSLFKAKLTDIRRQERKKTEETKKILNARSSLATSKTIMPPEEEVST
GKDRHHVLKDPKTGLYTERFVKRVLKEEVKRAKRYKNSLGIIVGTIINAEDIERSGGPIA
KAALDIESARVLQECIRDVDVPGKLDDGGFIVVCPETGEVGLQIIIERLHKRLNYNQKVN
LRTTWEPVFCFEAAAFGTSLNNPDFLLNSALEKLTLTALETKAEMENVVNEEKW
>A0A8G1FYH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MTQPAEPSHERLKQHFAQRVIHQARQILEIWQRLQRGEWSSGDLGDLCEANLRLQRYAER
FEQPEHGSLSTAIGQTLRAIEANSARLNSELISELNRLMQRLSRTGLRKGDQLDNVPLPP
LRKPVYIVLQDHDRAERLAQQLEFFGLTVQALCSAEAFQASMSERLPSAIVMDVDFTGAG
VGLQLAAQAQQGLEQPVPLLFFCLHETDTPTRLAAVRAGGQEFLTGTLDASSLLEKLELL
TSATQYDPFRVLVIDDSRAQALHTERLLNSAGIITRTLTEPIRTMSELADFQPDLIILDM
YMPECTGPELAKVIRHNDRYVSVPIIYLSAEDDLDKQLDAMSEGGDDFLTKPIRSRHLVT
TVRNRAARARHLKARMVRDSLTGLYNHTHILQLLEDCSFRARREAQPLSFAMLDIDHFKK
INDRHGHPMGDRVIKSLALFLKQRLRKTDFIGRYGGEEFAIVMPNTALEAAHKVLDEIRR
RFAEIHYPAQPHDLQCTFSAGVVQLDDSLDALTMASAADEALYRAKHAGRNCVVRVEP
>A0A2U3QG75|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MTISIVLLLLVNFVYTFSNGLGTSDVLFLFHAEWHIKNMLTGFILGASTLIQFVTAYLAL
RLIKVTGNRTSWGLISLAISFMAIRRSISLYEFVSGDYRYPLDLSFESVGLITSILMLGG
VVLISPLFKSMADEITRRKEVEKALRKIDKELSNITSNIGEGIWVFDKKGVIVFMNPEAE
RLLGWTIGELKEKGAHNLIHCCSADGASLPTEECNILKVMRTGERFHSRDEVFARKDGRI
LPVSVISTPIMEDGEIVASVTAFQDISELKRAENKLREMSLRDELTGLYNRRGFLSLIDQ
YIKIAKRQDKIVFMLYADVDNMKAINDKYGHLEGDEALRESAIILKETFRESDIIARVGG
DEFAAITLEASQADMHVVVARLQENLERHNSKSNRNYILSLSWGISHCEPESVCSVDEVL
SQADKSMYEHKKSKIKL
>A0A2U3QFM1|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MIRIISAGKIFIGAAIMLLSIVTALEIRKNASSFLYSRWVALSWFSVLFFLICVCVIVPL
FPLPFSPEILTGSILLTGAAFVYFVVRTAGKTLSDIVEKEKEIVTVTEKMAVANAELREI
NESLEMEIAEHRLAEAALMKSEEKYRSLVESTDDSIYVIDREYRYLFINKKHRARMGIDD
GDYVGKSYGDFHSPEITKEFRKIVEEVFAVGRSLRVDHLSERDWEHYLLTLSPVRSSDGG
ISAVTVVSKSVTEMKRMEQELRELSLTDELTGLYNRRGFFTLAEQHTRMANRNKNRVYVL
YADMDNLKMINDTYGHHEGDAALIVTANILKNSFRDSDIIARIGGDEFVVMPIGMTESEA
KITVGRLFNCLEAANRDRNDNGRLSLSVGVTHYDPQHPSTVAELLVQGDKAMYENKKDKK
SQQQ
>A0A517W3M6|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLELSKDSDTDIKDVIETIKADPAITAKILKASNSSFF
SLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITEGPLKPRFDSYWKQSIIQSAAAEL
LAAKLGNELQHDSFLIGLLQDIGHLAMLRSIPDELVNVLEQAEEQQRDTAELETEILGIN
HAEVGVKMMERWQMSEQFKTAIQHHHDTFEELQELKSHPEFNAIITIATSAAIGDYFCSP
NSGLALQRLQDLTTEFFEMPHNDLHGFLESVQARFEEAAQVFQVNMDDIGSPYEIMATAN
EQLVRLTMKAQVDSTQASARQAVIEEQKVQLETENKQLQSKAVHDPLTKVYNRSFFNEAF
EKEIYNCARTATPIGIVFADIDHFKQLNDTYGHQFGDLVLQRVAKIANESTRRSDVFCRY
GGEEFVVMVSSPTETGIQELAERLRALIENEVIEFEGKRVPVTASLGAVVGIPSRNTAGL
EERLIAEADEAMYESKANGRNQVHIRSIIRKADRELQQLVKRSRFSRWLVTKKIFDIPTI
SKALLKCPKQGPLVKLGELAIAEKLLTAEEVAQILETQKENGQRFGEITIQQKLLTQEQV
AYLLALQIEPPIALGKTLITLELLESTHTAELVKQYLAETKDSSAPLEERRQEPVKS
>A0A8J7V697|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MPNEENISAHTIYILSAVELEDVMACTHELCARVLGAQSTVVMMWDADLEQISEHRMFGA
MVTEMTELAEAIQDVDGDLLSRVLTSTDTPVSRSTGDIRVEFIDSRLINKMDAARRLSIL
EKLGTVLTLRVFFKGVLSALVVISGPDLPSALHTQDLVSGAPIAVALSRAWEMKELQREN
ERLRSQYEEIEEKTSSMEEQTLKLIHDITARDAIRMKHLERERLVYWISNAVRSSVHIKE
VVDTTVEKIGTTFGVSRCLLLRAEKTTSDDVTDMEVFEFCRNGVEPARELFFTEDGRAFT
KLALSKETPESIEIQDLSTKATYDPNFLNLLSLRSGLIVPLIMRDTILGVLFLQDISFDR
DWSIDDISLIGSLADNLSVAIENAELHQEREKQAVTDGLTGVNNRRSFNENLQKEFERAK
RYDQPLSLVIVDLDFLKKINDQYGHMAGDEAIRSIGGVLKLSSRSTDFVARYGGEEFCLL
LPNTGIEMAEQLAERLRRKINEITVTGYGNISASLGVSNFPLHCNDAEELFGTADAALYK
AKQGGRNCVKVAADLIVDLSQTGPLPAVQMQAIATTEDSTQASETAS
>A0A5K1J024|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCTIVLIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYISFDMIWTLSDGV
DGTLGIAVNWISNAVSFSLFAIVCLIWFIYSETVQGSRLLASRYRVLLVTLPTALVVVLA
FASYWTHALFYIDARGVYRRGVAYMIQPIVSYCYVIYTSLHAFVHSLRVESLRKKAIYRT
LAFFAIPALVGGTLQVVYSVPGLCVGIMISMLSLYIIYQEQLISTDPLTGLNNRNRFETY
MLSTFSNVDQAEDVYLLMMDADGFKQINDRYGHVEGDHALQVISAALKEVCSASGGFIAR
YGGDEFVVLQKATTEQDIMHLCATINDELARAEVPYLLRMSIGYARVGDGVDSWQDLLRA
ADAELYRVKREKKQAGVQIR
>A0A174IS86|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCMIVLIGLAARSRRSLFSSTQQLLFSMLGYTSAAYIFFDMIWTLSDGV
STPVGITANWISNAVSFSLFAIACLIWFFYSETVQGSRLLTARYRVALVTLPTVLVVVLA
FTSYWTHTMFYIDAQGVYRRGALYMIQPIVSYCYIIYTSLHAFIQTRKVESLQKNAIYRT
LAFFAVPALVGGTFQVLFSVPGLCVGITLSILLLYIIYQEQLISTDPLTGLNNRNRFETY
MLSLFSNVDQAEDVYLLMMDADGFKQINDRYGHVEGDHALQVISATLKEVCSASGGFIAR
YGGDEFVVLQKATAEQHIMCLCAAISDELARAEVPYLLRMSIGYARVGDGVDTWQDLLRA
ADAELYRVKREKKKAGVQIR
>A0A380T8P9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MVKNKPTTLACNPPPEAAQTLLALMHAQGEVARLSEREQLFSSLLDSVNAVLWAFDWESR
QVLYVSPAYERIFGRPAGLLLADFNEWRDSIYPDDLDYAERSLAEVLVKGAVEDREYRII
AADGQVRWISDKCFINQQSDPDQRVIIVGMAEDITEKKQLEGELQRLATTDVLTQSSNRR
HFFECAQHAFETARLQQTPLAFLLLDIDDFKQINDTYGHQEGDYVLQRIADTGKAVLRRG
DQFGRIGGEEFAAVFPGCTPEIAQQIAERLQREIQRLSFSHEDKVFGVTVSQGLTGITED
DESLDSLFARADAAMYQAKRQGKNQIVRG
>A0A2D4XRZ9|diguanylate cyclase|EC 2.7.7.65|Pseudomonadales bacterium|TrEMBL
MPRLSVEQLSQEWSLLNQRFSAQSRRFVLSFCTRHAVDLTEQFYSEMLADPAAALFLSHD
QVQGRLSQSMRRWLEGLFDAEAEGGLTRIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIELLHEDRELSDRDHLDAARLMSDTVDLAMEIMSHAYSASHDRNSRNEEAYRLFSVTQN
IAAEKETQRAALFDWENQLMFDQAVGQPGAHLPRILASEFGLWFRHKGAHAFEGSREAGQ
IIEAMEQIDDVILPLFDGDAEERIARLRELRETVKSIRFNLDNLFEQNNALEAGRDVLTR
LLNRKFLPVVLNRQVSHARTHGTPFSVLALDIDYFKRINDSFGHDAGDRVLQQLATVLVN
SSRAGDYLFRLGGEEFLMLLVDTDLNGARRTAEKLRASVEREVFRLPQERTLNVTLSVGV
ACFNGHPDYQQLMRRADEALYAAKHGGRNQVVVAE
>A0A0K9T594|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M114|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1C5TJ06|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MAVKKRKISKFVAVTMAIFVVLYAVVFSTSLYVQKTAEQQCYDTLRKSTENLGKEIKNNI
YSNQEQLEIIADVIASRGNADSEQTKHILKSYMTRGQISHLEVLLPDNRVITSDGNYADV
SGILSYAEEVEKGEYVSPNSTVDISHGDKKVLKCAVPILKSGKTIGILYGIIEVDSLPTY
YVAESYAENASIYLIDGDSGDFIMDTWHLSLGNIADWSNHKVKNDLKTSEIDKDIKSGKN
GYLIGYSERAKENMYSYYTPVGINNWSVMLSIPESTVMKIAWKIKQAMYVMAVITVIIIV
AYFLWLLSLRKKDINKVEYMLEVEKSLFDAHKHTENVDNTLGKVADYMKAETAFFTKVKN
GIIDEVYCWSNKENFDINAAENRPVKVVIPGFNGDGTSMKFGKKLYNLRDYGLPYDYYID
SYIVTSVYDVKKRFVGVLGVVNMDKVWKNADYIENVAGTFSLAVNNISSYKSLREMGIID
SLTGLLNRNCFEQTIENLDKNEYRNVACVYIDANGLHNINNRFGHEAGDNMLKAIAQALQ
SKFGSDKTYRIGGDEFVVFTFGESEKQIEDDIESIKNDIEKQGYSISYGVSFSEVSTNAE
RFIKQAERNMLDNKYSYYHKKSVENNKDGDWTISKAHINEHDMDTFLSAVAPKFTGGYIV
NFDDDTVRVIYVPEFFKSMLKITNGKFKEALRMYLNEKVDSKYHRNYEPFFDYEWIERQI
QEGNIPEIEFERTNGELAKMHIIKAPDYSENHRETVWIFETIKEVE
>A0A1C5ZWG2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLENYVALSITNILAMLLLAFVVGRNNLLDRKMKRFFSTAIFCTILVILAEIGTSVFGQP
VASFSLPNMFFNVLGFSLSPFITISLAFVFNHKNYRNIFYLFLPAVTNMLLAMLSPKFGL
IFSISQQNEYFRGPCFFVYVAAYIWSMTILFKETLYIAKRYQNKDCFALLLLFLFILGGT
SIQVLFPSIHTTWSCVSLSLILYYAFFCELKEKHDILTGLFNRRAYEYEIQHLESLGYGA
IIFFDVDDFKKINDQFGHQYGDQCLSTIAGLILKSFSGIGFCYRIGGDEFGVLSDKADEI
DILNAISLFINNLNSSREQDCNLPLVSMGYSIYHKSEGSITQAISKADAQLYRYKKLHKQ
ETKEPGKTNCNFSRSLTERTPH
>A0A1C6I5U1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MPFPIYIGWGLLAPVCLSLFYGSLSYPAMKALGYQPNHSVRYRISVYLFPMLLFLGWGMF
NIPLPLMYILAFLEKMFRIDRKNMGHTKELILVNLSHLTSMALHMILIGVFSLILRMPMN
ELLRQPFWRILTICSVLAANSLLTLLIPHTDIVGEVFRTQAESAEVRPFLIFLWFCNAFL
LVDSVLCISSIDWRLLPLFLVGSTVLLEFYLIRFLKHLYNLLKEHYVEEEHRSLMKKLEQ
QKQDAAKLRSRSERDPMTKVFTRRYVLEQTEFLLKEKKPFSFVYLDLDHLKQINDKEGHE
AGDLYISRFAEEFSRMLRKTDIFSRVGGDEFVVLLPGCEEEKAAERMEAIRSRLSEEFHP
PYSFSYGIFYVSGRNAHSVEQIFRSADLAMYQDKQARES
>A0A1C5SWD7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIIIVVILYVKIQRTNLSIYSPVKSIQSNLKHLSWVAQRVAAGDYKQHVSSLGRFSDSFN
EMIDQLSHYREKMEHISNTDVLTGIANRRAFNQMIKKLWDKDIPCVVVFIDIDGLKYVND
DYGHSEGNHYIKEVCQILKMNLKEDELIFRIGGDELLILLKKEDAYTCEERLLEIRLQFR
KEMKRKYRIHVILVLVVWILIKKKTKQLMNI
>A0A1C5ZX17|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNKLRKLNSKYMFLILVFIICFIGLFVYLKGDMYKCKILSEDEFATLKTWTVEKDNSKVI
LPCGFKYTGEPIVLTKKIDKVNAFDDSQYLMVMSRYFDYTVYLDDTKVFDLTTPQNGFSK
TMGTQLRLVRIGKDLNGKTIKLEIRPLLEDHIQYSVVPMMIGNRSDIIWHILKTEQSEVI
TAVLIIIFGFVLLLLAMIIRCSEYEDDESSKMFYLGMISVICGIYLACQFKVSHIIAPNG
YLPYYFEFTSLMLISVAVSLFIQTNVDGVIKKLYTSMSCIFVLNVLVQTFLNFVLKIDYK
MMLFVTHILIGLFGILILSTMIIFHKKKSIQYMLISIMFPIVGSIIDIVRLYRISDDKTI
YFFSMGLYIFVLMQVTRTIRQYLAKSRSHLKAEVYEHLAFTDGLTELNNRLSFENDINEC
IGNNRPACISIDLNNLKRANDTMGHSAGDVLIRGIATVLREAVGKDGKIYRIGGDEFVVL
IHDITDDGIEKVLKRIEKCRVKYNEENNVNLDFAKGVSLYTEGDTTFENLVARADAEMYR
DKRLTKKGRRDDYE
>A0A1C6DF65|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEHSIKAGLMITSASDYNMEICRGANEACKELGIELVIFFGGSVDPNVKFVQSSDYQKAN
VYAFANYLDLDFLVIPASSICRTDQKTREAFPKYFHIPVVTLNSQIKDYPFVVYNNKKSV
YNAVSYMIEKNHCQHIGIITGYDSGVTAKQRLAGYQEALSSHDMPFEEKYILSTPGYNID
SGNLMNKWLQENPELDGIMCVTDDIAYYLYRELEKIGKRVGKDIMVSGFDDKPESTHMVP
PLASCHADASFIAYLGIKQGYDLYKNGSTQNQYIDAHFIPRLSVDCENHEEIEIGEFIRF
CRAEKESNEYIAQGMTQYVFGNKLVYSSNYQKTVWSFFTYLLDLSVKDCTKHRVYQQIGD
YINLIFNEDDIRYLDLERLFLCLSFLINTENYLNMEDKIKLQSFKQYIYLQMISSYNYLL
LLKEKRYTRRMRSIGQVNKGMLFESLNDDIYAIADNIPSLGIHNAQLYLFETPVMTYEFR
PFIMPKTMELIINVENGQRQPIKNTHVLLKDVLNLAKQPYKILTSIYSNENFYGFLVTDC
TYFDLETLEYLSNQIGISLNVNAIVRELNSISNTDELTHIYNRRGLIQNIKVLYKKYKEL
SKNLYFFIGDLDNLKYINDTFGHDQGDKAIQTVCEILNDIFQTHAVIGRLGGDEFGIAFT
CKNEDFIIQIDSLIQERTQYFNKKYHLPYYVSLSYGISVFDYNSPFDLNHTIRLADTLMY
ERKKEKHIQRGKKG
>A0A1C5SXA2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIDKDQELFLDYIKQLLYNTDEATLCRDELSDDVTQLADGIEYLGEVIKDEKIVLSKMAQ
GEVDEEFSISHNYLAAPVKSIQSNLKHLSWVAQRVAAGDYKQHVSSLGSFSDSFNEMIDQ
LSHYREKMEHISNTDVLTGTANRRAFNQMIKKLWDKDIPCAIVFIDIDGLKYVNDNYGYS
GGNRYIKEVCQILKMNLKEDEFIFRIGGDELLILSKKEDAHICEERLLEIRLQFREEMKK
KVPYPCDFSFGCVDIDKKENKTISEYLSLADKKMYHFKMQHYIDQRRPKYSNHIDKSGLD
SRIFDAFSQTSINRYAYICNMETNVSRWSVQAVKDFDLPYEYMYDAGKIWEEHIHPDDCK
EYEEDIEAVFSGKKECHDLTYRARLKNGKYIKCRCEGYVLRGRTAKEPNLFAGILTRVDE
AVNYEER
>A0A1C5R8H2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRKWKAWLFALAVLIGIGTIGTVSVTAEAQNLNQGKRVLFISSYSYGWDTVQTQIEGIKA
GVDEKTTVDYEFMDTKRFRTKESTEMFYTMLKYHLDHSDPYDVVIVGDDAALRFAMAFRE
DLFDDIPIVFEGVNDEEYALEAAKNPLVTGILEKLSVEKNIDMALKVNPSADKVVAILDD
SVTGEAERKNFYSAEAKYPELEFSEINSSELTTAKLQQAVSKVDENTILIYIVMSNDGSG
KQYTNAQAIRMVVTYSKVPVYRMVEDGIGAGLLGGNVVSMYKSGEIAAQMAMDIANGTDS
AEINVVKDSPNIYCVDEDVMRKFGLEASQFPKDTEFVNHREGFFARNREALIPALILIAA
LDVIICWVCFDNYRRRKLLQELEQARAIMESAAQHDFLTGLPNRSKFMKDLEQLIGARIP
CTVMMLDIDNFKKINDTYGHTAGDEALQQVANRLKDMQSQILTSYRFAGDEFILILRSSQ
SMLVEKTAYQCRQVFAKDVTLCGTKRRIGGSIGIASYPKDTDNLEQLIVCADDAMYKVKK
NGKNDFAYYGKSTEE
>A0A245ZCT2|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MVDPMLDRAMALAGLGAWSCNLADERLSWTSGVYELFGLPLETAIDRRETLAMYTEESRA
TLERLRALAIKRRGSFTLDAQIRRADGAPRWMRINGEVVCQADGTRLLHGMKQDVTEEKA
RFEALRRLAENDALTGLANRAIFEARFLNHDRAAPDLPVGALILFDLDGFKAINDRYGHL
AGDACLQAFAERLAASFPEAVVSARIGGDEFAVILGDEPAPATVEAKIAAFAQRLRAPVA
WQGHLFTIGATSGSAVPENRMCYDAEALFARADAALYVAKRTRRRRRTDRR
>A0A1C5KP14|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNKSRKQKGAEAFCITVILIFLFLLVRILYQPEATAERISISSLGSGWYQIRDGEKITLE
LPCQVLTDADGKAVLYNDTLSAEDKGKIVSTRGIQDHLEAYMGDRLLYHYSDNSFLRNKP
MKGKLWADICLPDETGEEPLCFIFEGKENSLLYVQAPILGSFSSVVGRHLQESIFLILMV
LGMLGMGIVAVIVFLYARHRQMLEKRFLNVAFFLILCSLWCIFDSGLYQMYGRQNAAGTL
ISFYAFMLLSIPMLRFVQNTVRSEVRWIPQIWMFLFYGNTILQGILNLLFQIPFIHMLVL
THLLLFTGVASMILLLWNEYRKTGTQELSLCLKAFAVLGISGVLALILYWIFSIYWYDTV
FQFGILLYIAFLFWGLLCKVANDSQFRLEQAVYERMSLEDRMTGLKNRKAFEKCLEKIQD
DSLLLENALLLFIDIAGLKEINDIYGMQLGDEAVIRTARSIQTAGNMISEQQAECFRIDG
DEFAVVVSDPQKLPSEWIRLIKAEMENEAPGKYHVRLKFGYSYLRKTDGVLNSVSDWKQQ
ADRMQHSNKEETAEADYDLSY
>A0A2S9YHA4|diguanylate cyclase|EC 2.7.7.65|Enhygromyxa salina|TrEMBL
MGRKAAWAESITRGFVGWCHVLVDCAKVTRWTSTRRWVNPRSAWTWAAIGLGLAPGAPLG
LWVVFKLTGADLSDDVCQMALIYSGVATAVVFVTFGGLTGRLMDRLRSASLHDGLTGLFN
RRFLRESLPQLQAAAARRSQPLCVLMLDLDLFKRVNDAHGHLVGDQTLCAVAETLRRHSR
RSDLVARYGGEEFAVLCPDTDGETGLQVAERLREAVEALGEDRLGHPGPQTVSVGVAIQS
PEHELAPEVLLDHADMALYRAKHRGRNQTVAWLDGQELA
>A0A446CNC9|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MYVDLLTLYFIIIGTLLATAGLTFWEHRAHPKRSGSLRILAAGFATLALGCTAALFRGQA
PGGLGSATANLIVLGGYLLVMNGAASLRGKRYRAASFALLIAMALVWAAAGAEGEDFVWK
YVSAFPIALVSAATTWQLLRCDALKALKPLRIAAAVTGIHALIYIARAFILPWWVARYGP
GVQLAASTLTMYEGVLYSILLPMTLIKLVREETHGELVRESQTDYLTRLGNRRWFFEQGA
RLIEDGKGRVPVAVLAFDLDQFKAVNDRYGHQKGDQVLQSFAETARGMLGEDAILARIGG
EEFAALLSGDAAHRAPALGESIVRRFAETISNRVDDIGIAATVSIGLAQYEQDAPPLAEA
LAAADRALYRAKALGGNRLVAAGAAALRVAAG
>A0A403A0T4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLGNEQ
VERQLKSAMERWIINVLSAQVDDAERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8I0KYE8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas balearica|TrEMBL
MHITNEELAGEWQRLTAAYAPAAADALRQLAEQESAELARYFYAQMLADPQSAMFLSHDQ
VKTRLSASMQRWVCNVFRAPDEPRFIEVIEQQRKVGEIHARIEIPVSLVLRGARALKHRL
RELLEEQGLDEPLRRQAARLGADIIDLAIEIMCFAFSQSHDRNSRAEEAYRLFSVSQNIG
AEKERQRAALLDWENQLMFDFAIGNTATGLPQLASSEFGLWFRHKASHAFQGSPESASIL
GYIDSIDRTLGELCEAPPSAERGDLGLLHQVREQTRAIKFLLDSLFEQANDLEAGRDVLT
RLLNRKFLPVVLSKEVLYSRQSGSTFGVLVIDVDHFKQVNDRYGHDGGDQVLQQVATLLA
SNSRGGDYAFRLGGEEFLMVLVDIDASKALQIAEKLRKRIASETLRLQKGGELQVTVSIG
MAVHDGHPDYERLLKRADEALYQAKHEGRNRCVVHSSVS
>A0A3R0JND5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRF
NRLCEDYTGLNEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQR
LFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTDSITGLPNRNAMQELID
HAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGD
EFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDSAAIIRH
ADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEV
RSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVAKWRDKGINLRVA
VNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSQLGAQ
VHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQMIA
EGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRA
>A0A3P6LNM5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEK
ERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPL
MENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKM
LRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHA
AGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFI
WEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSER
AAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQTFRRSFS
DPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLVNDLLEQLENSPLPP
RLLHLIIPAEAILDHAESVQKLRLAGCRLVLSQVGRDLQIFNSLKANMADYLLLDGELCA
NVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGEVIADAQPLD
LLVNSSYFAIN
>A0A1V5SKU9|diguanylate cyclase|EC 2.7.7.65|Candidatus Atribacteria bacterium ADurb.Bin276|TrEMBL
MRESRERLTATLHSIGDGVISTDKNGFITNLNPMAEKITGWKASEVKGKMINEVFSLRDE
KSNISFNYQITGVLNGKGIHNFASSILLVDRNDIAKPIDGSIAPIQDQYGKRIGAVIVFR
DQSMNRAITRDLRIMKSSIESSINAIAMIDLNGMITFFNTAALRLWGYEKKEEVLRRPIR
YFWGKDFEKFQVLNKLRENGAYFGELAGRKKDGSFFDVQVSATLVTNEDDQPVCIMGSFV
DITEQKQAEKTLAEEAIRRRILIEQSRDGIVVMDQEGGVFEANQRFADMLGYTMDEIYRL
HVWEWDALFTREQLLSQTQLVSEAGDHFETKHRRKDGSIINVEISSNAAVFDGKKLIFCV
CHDITHRKKMEEELRRERTLLRTLIDNLPDAVYVKDRETRKLLANPADLENMGLKREEEV
LGKTDFEVFPQEVAKQFYKDDMFVLNNRKSIINREERLVRPSGEERFLLSSKIPLFDEKG
EAIGLIGIGHDITEQRKANERVNYLSFHDSLTGLYNRVYLEEEIKRLDTDRQLPIGIIMV
DINRLKLINDAYGHPMGDQLLKTSSSVLKDVCRKEDIIARWGGDEFVIFLPKTSVKEIEA
IKKRIIEQCKRTQVCSIPLSMAIGFSVKTRADQDIMKIFKEAEDNMYQNKLIESRSSRNT
FLLTLKSALQKKNDISDEHIAYLQNLAQIFGETVNLTGTDLDCFVLLVTFHDIGNIASPD
ELLNKTSPLTKEEQSIIQRHSEIGYRIARNIDELSGIAYAILSQHENWDGSGYPQGLKGE
EIPLLSRLNAIITAYDTMTRKNKFNQRGGVCPKVRALKELKRCAGKQFDPELVNLFIEMI
NNLPE
>A0A0S4HYG0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MVSQRLTHNAIQRLLLKRFALAAGTYALALMLLWLAFFTGHYNEPATSVAVGTAMVIISQ
AALFAVFYSGCNLRFSDPSLTEVQVLMGLGWQTWLIANLDEARGAFLVFYVLILLFGLFH
LSRRALVRCALLVFFSFSAITLWEGYRFQLPDPALAGLQVSVLFIVLIWLVLYARYVQAS
RQRMRQRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLASRELNAMDAGVMH
GLALIDLDHFKRINDVHGHAAGDQVLQAFAGVATACLRDGDVLARYGGEEFVVLVPDCDA
ERLTACCERLRIAFTDVELIGLDVAHLSLSAGMTLLELGDDLDDALQRADQALYRAKRDG
RNRCAAAWENVDA
>A0A3R0XHN5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLNEHDIIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINHANNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKAL
>A0A0S4IB42|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MIERTGTGLSFAKRMYAPRAIGTGLGFFCVLIGIAPLQPEWWVWALLLAHGFVWPHLAFQ
IARVSAQPYKTEQRNLVVDGFAGGCWAGAMGLNPLPSVIILSMIAMDKIAAGGWPLLIRT
VIAQGIGIALGLWLFAPPLFPATTQVQMLACLPILLIYPMAIGMICYQVTVQLGQHKRAL
ARMSQTDSLTGLSNHGAWQELLLREFARCRANAGSSCLALIDVDHFKQVNDRHGHQVGDN
ILRVISATLSFHLRKHDPAARYGGDEFCVMLPDTTPGQARDVLERLRLAVEAFRDPALPH
LTLSLSIGIAPYHAGITDAQAWLHAADMALYAAKRAGRNCIVLAPQASEPA
>A0A3P6M4N2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILAPGITPVRIQAILSAIS
>A0A517MXX3|diguanylate cyclase|EC 2.7.7.65|Adhaeretor mobilis|TrEMBL
MLSISDTLTSDTPEVATPGAHAASAPAEGTVTTRMEATQTRVAEISSLLSALENAAAESG
LSVKNASAQPVPTNEHENKLVQVRLGMASGLFNSLKHKHPQSASHCLRVALGCSSWAFYK
KLDDESHDAVELAALMHDLGKMGVPDSILLKPGRLNAEEIATVLEHRRSGVEILASCCSS
QRVLDAVKYSTASFDGTSGDLPLKGEQIPVEARMIAIIDAFDAMTTDHLYRQAMPRDRAI
AELFECSGTQFDPVLVKQFVDLLSQRQDLLTEKVASRWLGELNTHSREMPWQLGQASSVP
ADLVPSRPATKPQAINGHSLFEQKLIDAMHDGVMFVDEQSRIQLWSKGAERLTGVSAGAA
QGRIFTPDLLDMCNSDGRRVANDSCPVAQAIKSSSQIRQRLQLLGRQGTHVAIDLHAVPV
HGTSGSLLGATVMLHDAQPEASLEEKCEALHAEVTKDPMTKVANRAEFDRMQALFIDAHE
QACMPCSLIMVDIDHFKSINDTFGHQAGDEAIITVANLLKSMCRSGDLVARYGGEEFAVL
CADCGNATAASRADQIRRKLSETPHSVLGNKRITASFGVTELQAGDNPESMLRRADRALL
MAKEQGRNQVVQLGNGMEEQKKKKKKWWSLGGIRGKAVIETKLSSMVPSDIAIEKLRGFI
SDHKAKVLSTKENRVDMEITSETVAYQRRNGDREIRFIVEIEFSEERFEKTNGAGFGAGK
QVRTHTIVKVRPKRGRSRRNADTAERARLLVQSLKAYLMAREDDGTPQDEPRRFEPTVV
>A0A8H2RZ37|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTPSPNPKAASCFAAVRCIQDSIEFGDRLEMSERTTKGLTFAKRMYVPRAVGTGLGFFCV
MVGIWPLQPGWWMWALLFGHGFIWPHLAYQLARRSGYPLRAEQRNMIVDGLAGGCWAGVM
GLNPLPSVIILSMIAMDKIAAGGWPMLFKTLCAQAVGVGLCLLLYTPPLFPETTHEQMLA
CLPILLIYPMAIGLICYQVTVQLTQHKRTLARLSKTDSLTGLANHGAWKDLLVREFEHCS
RTQQPNNLALIDVDHFKQINDRYGHLAGDNILRTLGATLASHLRKTDLVARYGGDEFCVM
LPGTTPHEAHEILERLRQTVETYHDPELADMKLSLSIGIAPYGDHFADADRWLHAADMAL
YAAKNAGRNTIRQASAPD
>A0A564ULS6|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKEKLLTKNKSQRMLTGVMVALFFVLSVCTIFTGKYVPTEKGLTLWEPERTQKQDDGTRH
IYFTADTDREDRSSLVFFTSHQWVEVFADGKQIYKLDYTGGIWGHTTGNVWNFVKLPEDA
TQIEVCLTACYPKIVGSSNKFYVGTGNEIYAALLRQSMPVFIISMLTLMVGLFIVLYWVI
IHKSSQIDGTLLYLGVFSILLGLWSANETDVTALVITNRQASAFAAFAFLMVMPMAFIMF
VKSFLEIKDEWYWKRICDINFGVIVVSFILNFTGIYEFRRSLWMTHMIIVLMLIYVFAVI
ITKIVKHQVDHRFKSCVGALALISVATIVDMGRFYKTSNNAGIFGNVSFLIFIVALGIES
AKQAIESMKKRHRVAELEQFALNDSMTGLYNRNAYDYFANNAKKLENHMIVTFDLNNLKS
CNDTYGHSTGDLYIVNSAHIIENIFERFGKCYRIGGDEFCCIIPKAKDFNVERFIQKLYQ
DVEVFNNKNIIPTEAAIACGYAFFTAEDTDIEKVRERADEMMYQNKKKLKGRD
>A0A5E6TJ43|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENQRGKGLSFARRIYLPRAIGLGIGFFSVGAALYPLNMPGWLWALLLFNGFAWPHLAYQ
ISMRSAFPYQAERRNLLYDSLCGGFWAASFQFSPLTTVTILSMMTMNNVAAGGYRLFVFG
ALAQLAGVLLGWMIFGVQFSLTMRQEQVWACLPMLTLYPLALGMVCYRLAIKLSQHKRAL
SALSRTDSLTGLLNHGAWKDLLHLKFQQCRQHNSQATLALIDIDHFKDINDSFGHIVGDE
VLRQLSHDLKRLLDQYELAGRYGGDEFCVILPTRPLNKAEALMEQLREALQQYRHPQVPD
LRVGLSIGLARYQPLYKDALDWLDDADKALYTAKHTGRNTISVALSRAATDNASA
>A0A3S4N1P0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDDLTGIPEDPQEAALALLHSRAEVARLKEREQLFSALLASVNSVLWAYDWQNRRMVYVS
PAYEKIFGRSAALLLADYEEWRNSIYPDDLDYADSSLLQVLERGAVEQREYRIVRGDGEV
RWLNDKCFVSRQGEAGLPLMVVGIAEDITDKKHMESELQRLATTDVLTQSSNRRYFFDSA
EAAFKECRREGIPLAFLLLDVDDFKKINDRFGHQVGDQVLQRIAQSGSAALRRGDLFGRI
GGEEFAVLLPGCDEQTARQIGERLQREVQRLRFQEGEHSFGITVSQGLTVLQADDEGLGA
LYSRADAAMYSAKRQGKDCIVVG
>A0A173ZH00|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKTIIKYELVINEALRSALNYNTPDEQINEFIRFFGRHIGSDRIYIFEDCKERHCTDNTY
EWCAQGVIPEIDRLQNVDMDVIKWWYYTFSKGESIIITDIEDIKEEHRASYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKSDYRGLTTFLDMIGTLLISFLKLRNSFIKSNKEAKL
SSYSSLSKIYASMYLVDVQTKRYHIIKMTDQIAEYLGKDFKMGEYEIRDDFCGHIKNIAE
KMCTESQLQESLEFVDISTLEERLLGENSITHEFTDKISGWNRSRFIPVDYDEDGKLLHV
LFCIECIEEEKKRENRLIYLAQTDLMTGLCNRGSGEKKITEFLKEKTGGLLCLIDCDKFK
SINDNYGHSVGDKVIIAIAEKLQKTCRDSDVVLRLGGDEFAMFIPGMLEQRVAEKFFERF
FENIRQIDIIEMQGKNIEISLGACFYDGYEEVSFDQLYRKADRAMYQSKKQKGCSAVIYG
EEM
>A0A5E7RQ97|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLFRSNSRPTLGSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKSAANESLALIASSEEVADAQVLDSQGQLLAHWQRPENGLFSELEMQITR
AILEKPISLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKHDERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKVEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVFPDHGVTPGALLDAADAAMYQAKRLSRGAQFTAGAEHLVDSVQT
RS
>A0A240CAQ0|diguanylate cyclase|EC 2.7.7.65|Serratia ficaria|TrEMBL
MKIKGFIDFLCRVKSILERKSIRGEVNHGLSKTIRDRLLYYICVAASFTLLLAAIIFIPA
YKDYKLATRTVDDIKEFKELSELAILMARERAPTAIIMSREPTVDSLWGTSLKKHRDNVD
LAFSNLIETYKKIGVTYLNEIKSVHSQLILARSDIDREISINRSELKAGDYQKALHRMLL
VADNYQGYMSDRVIEIAKDNKSLAPTLFHALMITDLREHGGQIAGFLVSSLAAQVPLDIE
NEIAARRNITRTYEIWKLIQVHCQIFGCQSLVEQTKEINNRFFSDAFEPIYTVINESKSS
ERYKWTVSEFVNAFSPMLISFSKYRDALLYKAISDAELKRTASIIILIMLIAIIAIVCFI
HFYVVFTIRKDIFIPLIKVNEEVLLLSDDRPSGDYSTFKTKEMKEIWRSMEVLRNKVIER
KELLGYFRTLSETDSLTGLPNRRALEHIAGEISSVVEGELFSLVIMDVDFSKGINDKYGH
ATGDIVLRKVASVIRSVLGDAGIIFRYGGEEFAIVLRGHGLDGAIKIAEKLRITLENEII
YSTNNERVCITASFGVASAKGKKETWLQLFSNADKALYRAKKEGRNRVRALFEGEQ
>A0A5E6WQC9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKAVGKGLSLTRRLYASRTLGLTLGLICVGAAMYPLDPAPWVWGLMLFNGVLWPHVAYQ
WARRSPVPYHAEHRNLMIDAFLGGLWVAAMQFNPLPSAATLAMMAMNNVAIGGLRFMLAG
TVAQILGIGVGFVVFAPTFIPETSQWQLYACLPLLCLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCKRRDHGGAIALIDIDHFKTINDTYGHVAGDT
VLRQLSKMLNQNLRAADVAGRYGGDEFCVILPDVALESAAAVMDALRDRFATLGYEQNPA
LKVSLSIGLAAFNPAHTDATLWLNDADQALYEAKTTGRNRVICSGDGKPRVELLDPV
>A0A125QHG6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPDIDLAILTPLTLTINGIVAGYMLLLARLNIAQPAFNHWAASCIIFIFASLLAVSRLYQ
VTPIISVWLAHSLLALPPILIATGLLRFFRGTETALPTKMLGSIFAVYATLLFFTYKLSY
SAPILTAAAIALACFWCIALLNLNTMQRIISRLLQGVLLLHALAMFAEITLYIDQWQLPL
TRHIELYLKLTLISHLLLTTIASMLLPLLLFVHREQNLMLQANRDELTQLPNRRHFLRES
SAYMAKATGSSSVIIMMLDLDNFKSINDTFGHAVGDAALKQVARALEIELRKTDFIGRMG
GEEFAIVMTDTTEAEARAIAERLRQKVELRARVIEGNQVNLTISIGATCSYKHNSSGFQA
LLKLADDALFEAKRRGRNQVVFDYAKNDAKSIADS
>A0A5E7Q9I4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSQSESRANVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGQDPELNR
HLDRVLRDFDGCPPESASRLFREYIIRDELEDVRAEQQQVFSLVDGMERDVSRSVMGSQN
FQNRLGQCLEMLDEPVSDRLPGILSELQQSTRVMQSQQERFLGQLQSAQNEIKTLRDKLE
RAQRAATLDGLTELLNRTAFTRLLEQALGKASRRVALVMLDIDHFKQFNDQYGHPLGDRV
LQHVGQVLRGALPANAFAGRYGGEEFCVVLEGCADLASARAYAEQLRLKVQSLRIKARGT
DTVLDTITASFGVAFAEPGDNLESLVTRADDALYEAKRNGRNQVQALHQSPALQS
>A0A448DMX1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTQFQAKTRPTLGSVIGRGHLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKAAATEALAVIASSEEVADARVLDAQGRLIAQWQRAENGLFSELEMQITR
AILEKPVSLPIEHQDREIGRVLLIGHGGSLMRFLLSGLAGIVLCTAISAWVALYLARRQL
RAIIGPLHGLATVAHAARSERALDRRVPPARIAELDNLGNDFNALLDELESWQTHLKNEN
ETLAHLATHDSLTGLPNRAFFEGRLIRALRNGKKLDERVGVLFIDSDRFKAINDNFGHAA
GDAVLVAIANRVRAQLREEDLVARLGGDEFAVLLAPLFTIEDAERIAEKILTSMDMPIAL
AGDTSVVTSLSIGIAVFPDHGATPGDLVDAADAAMYQAKRLSRGAQFTAGTEHPVDSV
>A0A5E7KER3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRLFRSNTRPTLGSVLGRGHLTVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKTAATESLAMIASAEEVADAQVLDARGKLLARWQRPETGLISELEMQLAR
AILEKPIDLPIIHQNREIGRVLLTGHGGSLMRFLLSGLAGILLCTAISAWVAIYLARRQL
REIIGPLRSLATVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAYFEGRLIRALRNAGKLKERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVADRVRAQLREGDLVARLGGDEFAVLLAPLHKVEDAERIADKILASMDMPIAL
PGDGSVVTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRLSRGAQSTAGSEYPVNPVQT
RS
>A0A109KRA2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDDTSGKEPLRSEVSDLNVDLLHAIMELVSDGIWDWNANTGFVYRNPGWYEMLGYSHHSL
ENSVFTWENVIHPEDYPCVMAVFDDYISQRAAHYRAEYRCRKEDGTYLWIEDRGYVIARN
PDGSVARMVGAHRDIHTRKCSIEQLQKRNQSLEALVAERTLELSRVNQQLQLQLDENRSL
AERDALTRIANRYRLEKVLLEECDRAERFRLPLALVAMDVDDFKPINDQYGHGVGDQALI
RVVETLETCVRASDLLARWGGDEFMVVLPKSSLDTAKELAERIRHKIKEAAPVGALNVTL
SLGVVERRMGESPAALMARADQALYRSKAAGKDGVSE
>A0A5E6UPG1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MIGFGKGRERPTLRAVLGRRHLSVALLAVGLAGVSLTLLGVLALRVYANHNLHLIARSIN
YTVEAAVVFNDAGAANEALALIAAAEEVADVKVFDDNGELLARWQRNNSGLLAQTEQLIA
RSLLEEPIILPVLHQGQQVGRIELVGQGGSLVRFLLSGLAGILLCTALSAFSALYLSRRM
FGDIVGPLRSLASVAHAARRERSFDRRVPSAQIAELNELGNDFNALLDELESWQSHLQSE
NESLAHQASHDSLTGLPNRAFFEGRLSRTLRNAQKYNEHLALLFLDSDNFKEVNDSFGHA
AGDEVLISVAARVRAQLRENDLVARLGGDEFAVLLAPLHAREDALRIAEKIATSMKLPIR
LSEGQIIVTSLSIGIAYFPDDGLTPSDLLNAADAAMYQAKRNLRGQGQMAETERSAHPVK
NRS
>A0A1C5QGT0|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MFTSDTAKYKIIGICTSCVQSDYVRNIVSSISRKGVKEGYKVLLFNTFCDLYHNISYNHG
EASIFDLINYDILDVLIIMPEAIKRDSISNEISKRAHEHGVPVICVDSTMDNCCSVTFNY
SDVFEKIVRHVIEFHGCRRVNFIAGVKGNAFSEERIEAYKKVLAENGIEFEPERLGYGDF
WDMPTKGVLEKFLESSLEFPQAIICANDAMAIAACSILRERGIKVPEDVIVTGFDGIELE
QYNSPRLTTAAVDNDVLGEKIINAIDHMMNGVPLPEKIEVSYTMRISQSCGCKKIDPREV
GDKILELYHRMNNSDGHEQHMFSYLAKSVECHTVEEMAKVMARSGDYYSWVCTNSDFLSN
TRQRERFNNSFTKQMRVFMQTFDNKYKTGEVFDTKDLLPDMEQVLGRHNCLMFSPLHFQD
EVIGYAANSFSPIYFLFQNTRRFINNTNQIMESFKNRQRLERANAELARIHMLDPMTGIY
NRRGFYKNVKKLISKAEKQGVGVWVFSIDMDNLKKINDLYGHNEGDKAIKAVASLMTKCT
AEGGICSRFGGDEFVAVIAETDGADSFYEKVSRSIAEYNRRSKSPYDVSISCGYKAGKPK
TLKEIDDLMKASDREMYTQKRKHHSRRD
>A0A1V6IXH2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MNMKLHPITLRFSDENAHLEALFQKDYYRISLSTMRLFVFLGAVLYASFGILDAYVMPEQ
KIIIWFFRFIIVGPVLLGVLLISFTRLFKKYMQPILAALYVLAGTGIVAMIVVAPPPVSY
SYYAGMMLVFMWGYTLIRLLFIWASLAGWFQVALYEITAVFINPTPLDILISNNFFFISA
NLVGMMACYAIEFYARRDFFMKKQLESERENVSRINAELEERVAKRTEDYRVVNRALQEE
VAGHREAEKALRDSEERYRALVENASDMVFRTDIHGRFTFANVSTIRVSGYDESEIIGKH
YLELLRPDMREDAAGFFGLQIKNRIRNTYSEYPVIKKDGSEIWLGQNTQLITEDGKVIGF
QAVSRDVTERRRLEKELKESEERYRELSIIDDLTQLYNSRHFYSQLHMELDRTERREYPV
TLLLLDIDDFKVFNDTYGHIEGDRVLRRLGQVIKRCLRKEDSAYRYGGEEFTVILPMTAK
EEGAVTAERIREELRKENFSPLPDRDIRITVSIGLAEYEKNENIKSFIDRADHFMYRSKK
NGKDRIYFE
>A0A1V6IM91|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MDKKKETLFPLSLEAPVPEIYMPRLQLFVRLLLGALVALYINYSPVPPLVLSVNQVNLSL
VFYYAFHLLWWWYYRKYGANIIMFRLGGWIDILGAFIGALSDPFTIPPMILLFLIAALGN
GIQHGLYFFVESMIGSLILAGAVLVIHCRILGDWPPYHLYFYVFLIVVGVSYAYLLVRRI
EMMRGEAVRISEHDSLTGMRNRRSFLKAAQYLLLLNERSNISLVLMFADLDNFKTVNDQF
GHEMGDKVLRHFSDMARSSFRKSDILARYGGDEFVMLLTNTSPEAAQSAARRLQGEFGAW
AKENGLQTGVSFGLAAISKGKNNLDDLLRQADAALYEAKPKEGLKGF
>A0A1V5E4I1|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaU1.Bin208|TrEMBL
MDDWKKTKAHLIRELEELRARVAGYESIEQRQKLTQKKQKKKENSTLRNASLVDIMAGSA
LSLLTCPNISEAVDQALAILGEGANVDRVYLFENHQDPCTGELLASQRFEWSKAGIISQR
DNLLLINQPYRNFFPRWQSELPLGRSIKGLIEDFPAAEREFLAAQGILSLLVVPVMIEGR
FWGFIGFDDCHEEKEWTKEEESILVAAAGNIVNAIERKRTEEALRKSEDQYRTIFENTGT
PLLIFEKDTTICLVNAEFERAFHYSRDEVEGRMSWMDITLPEDLEWLKRYHYARRVDPGA
SPRNYELRVVDRFGHIHESYITIAMIPGTKRSIASVLDITPLKAVENALRESEAHYRTLF
EHTGVAIVHVNPQGNWLRANENFLKFIGYTWEELEKINARDVTHPDYIEQTAVLIEKQIN
GEIDRFSQEKYYVRKDGVLRWGEMRSTPIRDERGRLLSAVVAIIDRTQQKQAEDRLKKYL
EEMEDLYENAPFGYHSLGEDGKILRMNDTELSWLGYSCNEVIGKKYIDFVAPEGRDLWQQ
LFFLLQNRGRMNDIENKLIRKDGTLFPVLLNATAIYDEKGKYQMSRSSVLDNTERKRAEI
ALAEGEALYRNLFESALIGMFQSTLEGRFLRINQAYATMLGYESPAEVISTITDTATQIH
ADPRNRAELLAAVDRDGWFYAEQPYLRKDGGVMIGKLSVRKVVKGDGVSAYLEGIVEDIT
ERKKTEKALQESERELRVKATRLGEANMALKVLLKSMESDQEEFRERILTNIRDQVLPYL
DKLKHSPLNEFQRDYVQTSERNLKEIASPFLKKIASGCFNLTMKETQIASLVRDGKTSKE
IAGLLNVSQRVIDFHRKNIRKKLGLTERGESLVMLLRSLS
>A0A1R4B1L6|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MINFIKELKVSEKKRLVILSFLFILLSIAFVRFVTQEVYERISDDKKRDLESQVSLVRAN
MEAAIYMDTYLADSLAMIVTINPEFALKEWHSISEKVITKAQYVRNMGIAPNDIISNTYP
LKGNERAIGLNFRELPEQYETVLKAKESGRVYITEPVALVQGGKAIIARYPIFTDYPLNQ
NYWGGVSVVINYEKMLEAVGIQKISNAYVTLSKGNSILYGDGFLDQPDIKLPIHLPSSKW
QLEAKLNFSNNPDVSRYTTAACLISVLICILVYIVLLLLIRSYFFARRHALQDELTHISN
RRHAIQYLRNTLNSRANKPFSLFSIDLNGFKLVNDTYGHNIGDEYLKFVAQSLLGLTRET
DLVARIGGDEFIVVLLDVHKPGQVEVVLDKIDHHFKKHLFKSNDITLQVSVAVGVAVSND
KKATLDDLLAQADEKMYKDKYDKKNKMQ
>A0A221VXI9|diguanylate cyclase|EC 2.7.7.65|Actinoalloteichus hoggarensis|TrEMBL
MVDRNDSPLAEHLPQQDREVRLLLESGRVLEANALFDEVVSGMPPGEDDRWRRATVLVHR
AVVAFRLSRIPLALELAAEAWVELDAERPEGTAAAQTIGMLGYLVESIGHRRAALDMMRV
SVELARRAGHPETLAHCMQRLGGTLNMRAAEASPDDAKRIFSEAQGMLEEALSLVHTGFL
HRALLAAYSRSLAGLGELAEAEELAQRALRLNEIAEDRWGLAVANWVLSGVRRTQGALPA
ARTLASRAVAEADRVGDTIMLRRFSHDLADICADLGDHVGEAEALRRGMAAGGKILDTLQ
EALGQALEQRRLAVQAQRVAVAAQEAAARDPLTGLVNRLGLERTAPHLIKRTASRGRVPW
LVLVDVDWFKDVNDDAGHAAGDAALREIAQLLRRECRADDLVARWAGDEFVILLVDVSDE
RTEAGPTVAERIRAAVHGHDWRLVLGKTTRPPTVSIGVAAGPAQLDQLFTAADNALYRAK
RQGRNRVEVQPPAEDELNARAASTLTTR
>A0A2H5XQJ2|diguanylate cyclase|EC 2.7.7.65|bacterium HR19|TrEMBL
MKILERADIPLILSVILSFLVGVSDIEVNYKIVISLLLLLLGVFLKSKVKEREFKTANDI
IKDVKDFPEYVDIGSLKKRLPQQYHLFINAMEFLLKRIQEYEVQKIELENMIKYANVEGV
DRLRKELKTASDRIKKMEEKVSHLQIIYDITSKINSIIEAEDILDFVVKMIGEKLKVEKL
AVLLKNENGDLLEVKALYGFPKNLRNMKFAPTEGISGLVFSTGEYIYVPDTARDRRYLHW
KGEFVEYGSFLSIPIKFGGEIMGVLNFNKSGVASFSDEEIELLKRVADQLAIAIKNSNLL
KQIKSMYGKDNLTGLLNRTRMMEEVQKVISMGQNFSFVLFDIDDFRDINLKYGYSFGDKV
LVEVARILKEEFRRLDVISRFGGDEFAILISGASRGKAVREMEKISELIGQLGWENQVKI
SISGGISEFPEECKDAREIFEFADRKLLLAKKENKGKIIA
>A0A2H5XPL7|diguanylate cyclase|EC 2.7.7.65|bacterium HR19|TrEMBL
MEITLYILLFVLFSFASLALAKMRIFFILPKSFFIIPATIFIILLLLHIFGRIDIISFIL
IAFSLFILSFIIYREFISKILNFFEELKYIKNILENPEGKEEKASSPKSPDEKLEKISIP
ELSKELEEIFYTILKTKKGIKEKLVSADKHEKFIIYLTNFIRYSIAETDRYKLFREVGNF
LEYILPQNEIGIAIFEKSSEQEVITETDKKEKIKIIKGEEFLSKIIDSIAKGMIEEEKEY
TSFPLSNGEKYGFIVVRGELDANKKNLLYLISKLTSAILKRIETEEELKIKAITDPLTAI
YNRRYFMARLEQNFAKYRRTQKNYVVVIFDIDRFKSINDKYGHTVGDEILKKFALILKQN
VRGYDIPARFGGDEFVLLLDEIEKEESISVIRRITGKFSLYQELKAILGESPTVSWGLCA
VKEADSNYEEIIKVADKRLLKAKGLGGNQGVWE
>A0A6J5DXT7|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia solisilvae|TrEMBL
MASHTDRTTDRTLDRTTDQRSDLATGRGKRFVERTYRLRIVGLSLGFLCVASVFLGQQRG
IALWSLAVFHGFIWAHVARRAALACVVPYRGERLNLMIDSLFGGFWIVAMQFNVLPSVLI
LVMLSMDNIAAGGPRLFVRGVAAHVAGVALGALVLGIRFNPMSSMATIVACLPLLTIYPV
SLGWSMYRLSQKLAARTSDLEHLSRTDGLTKLWNRRHWEGQLSLEFERCRANGYASCLLL
IDLDHFKRVNDTLGHPAGDAVLVAFADLLRGHFRAGDSIGRYGGEEFGVVLPGATLRETQ
TITRALLVRVREQAREPDASCPCTISAGIAQLMPDMPDYHTWLLEADRSLYQAKAQGRDR
IIVAGAAAPAQPVASAKS
>A0A4R8SYL4|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MNAAEPGSSRRGETNVLVIESRPISIDRQSRRYGVTYRFLVMALETTRNAIRLKIAIGVL
CMSMTVLAVIMQFNPLGPQGLWPRVVHGIAAGSALLVGLAWIVRPWPTRPWAIAFVFWAD
TATAVGGSMSSQPVSQLGATNHLALIGIFAAFLLGWRVLAAHCLFATAVITALTLWNLHT
GAATLSELYVYNAPAYSNVVFLPIVIQAVIEGVRKSVHRNAIAAHRDPLTGLLNRRGVQS
AMKARLRREPRPAIVAVFVVDIDCFKELNDTYGHDVGDSTLKRVADTLATGIHNRDIAAR
IGGDEFMIVAFLDRSEDVDTVRARICDSSSNTPDVTVSISVGSAWQYTHEEDFTFESLSR
EADFGLYEAKRTRKNRHVPRSCTCYPSYPGAQGPCDTNMHVPTATMAHR
>A0A352RST5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp|TrEMBL
LLILRGMMLSRDTEIESVRQMQAVRAVSINALLQLEAERLANIRNYAEHLMQIQDELPAL
FAHDIQTAFEHRNDDVWALRTREAAPVYGVSAARLTGLDGFSRDDAKLIPGMAVAIALSH
MFSAGHNEPGLRERIAYVSASGIIVAYPAISEQDVDPTLRTFASAGYFRNSLPLANPTRK
QQWSIARSMDDAGESSLFLSAPVYAGNAFKAVLILEIPRPSLDESLNLAPHHDVNNYLVD
HNGILVGAGMRNVHRGETLASVLIDKWPADKLAVAFRGDAGILNNEHGSRLIYRKLGNSG
LIMVDEVSTRELLQASVARLSGTIGAGAVALGLLLCFTLAVVHTLFGHYIDRGEALRTLA
ETDALTGLANRRVFASRFADAYAWCKRDAVPVSLIMLDIDRFKKINDRWGHASGDVVLRT
LA
>A0A7G2JGW9|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MKWLRKNRSGQSRPTLGRVLQRVHLALALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFEDRSAAHEALVLIASNEEVSEARILNNNGKVLASWRHPKDGPLHGMEQ
VVAHWALPEPVILPITHEGKVVGKVWLSGHGGSLLRFLLRGMVGMLACLVLSTLCSLVLS
RRMLLGIVSSLDDIANVAHAVRRDRTFGLRVPSAPIAELHELSSDFNGLLDELEAWQAHL
KQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIKPKEKLAVLFIDGDRFKEVNDSYG
HAAGDVVLTTIAGRIRAQLRESDLVARLGGDEFAVLLAPVHTTEDVLQIADNIIDCMTQP
VILPNNETVISSLSIGIALYPEHAVTPQGLLHEADDAMYQAKHRYNGGWRLAIQK
>A0A8F8BJH3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. steigerwaltii|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIVSILRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A379U2P1|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNMLPAATLFMMMS
MNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPLLFAWV
SYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLIIDIDH
FKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSR
VHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKNAGRNRTEVAA
>W1XEJ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli DORA_A_5_14_21|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRR
>A0A7T1AJZ8|diguanylate cyclase|EC 2.7.7.65|Atribacter laminatus|TrEMBL
MKRKALKRGLNPTINQKNYRNELFNSFNQNNFNSNSFQPKDQIKVNNQKAPFNQDEKDEI
FIEENEDNRIQPMDNQVKFYFYEDEESFQDFTIKSQKYFSSDMILHDPLTGLWNRVLFEE
EIKRLDTERQLPISLIMGDVNGLKLVNDIYGHDCGDELLVDVATILRDSCRKEDIIARWG
GDEFIILLPKTSGVTAQAIIQRISELCQKRKTDTIPITISLGIGTKSHPGDQIKEVLKQA
EDEMYHKKTVESQLIRDQLFASLKFKYWEVKKLFQKEGNTQNLLYHHQLGEILQLDQQAL
NNLLLLAALHDIGKITIHRHLLLKKEPLTITEKLTLRKIPEISYRVLQYFPFTNQIADAA
LSYCEWWNGSGYPRGLSHEDIPLISRISSVVNTYDLMIQPRPYKSSLAPQEALIELQNQS
GKQFDPEVVKNFLKMMEEKAG
>I6DUI0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7Z0VPJ4|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MSVFRSFIQHLGDNSRIYSIGELDKLISSDEHPAYMRKHRAELLLERIRFIASLLSILIP
LWLVIDFLLLPLNLFWPIVVIRLLSTAHFVYLARYRTEQATLKTSLLLLAGMLINLPLTF
FASAHYLAMVPPESVYHLPLALYTLLPYIAVGLLGLFPLTLLECAVLALLIAMLTVTGWS
YYSTVPALELLPTLWLLIIILGIVLFTSTIQLQYMISIITRTDHDPVTGAQTRKSGVQSL
AKAFQQAKLQNEFLSIALVDLDNVQNIIAEFDYATYDHVVLEAADILSDGLRHNDMLVHW
GEKVFMMILPGTDCKGARIIAQRVLNQGLGTLPDGRPVTASIGVCERSADDIEEWSSMLE
LVDNRRDDAKRQGKDRYIICNEEIGMAAAE
>A0A330EQP0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAAAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGLTIGEIRLTARDSLISHFIWTSFAVLTGCILFAAVVALIITQSL
HRGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTIS
>A0A2T0B596|diguanylate cyclase|EC 2.7.7.65|Clostridium liquoris|TrEMBL
MTSVNRILYSILDNIDEGIVILDEDSEILLWNSHMECLTHINGKQAINSCIYEVIPGLNK
GYFKETINCALNDGRKMFFSAAMHKDLLNNNKNLNLKVSRIEKDNLKFVLMEFIDVTNLF
LRIDQLKKYVNELYILNKELKEKERTINKLAYYDGLTGVANRVLFYKIADKFCINSKRSG
SLLGLMFIDVDKFKCINDTYGHIKGDDVLVHVAKILKKSTRKGDIVARFGGDEFLILLPF
VKNYHDCEIVASRITNSNKVLLCGSDEIKISLSIGISILSNDSNDMDELVLQADRAMYKA
KSQGGNGYYSFVEC
>A0A144GWK3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLRNAVSRFNTLRMLPTWQLAVDK
KRTLPINGVSDTFVEKTTLLNRDDERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDHADDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTHDERTITA
SVPIYFDHYWYGVVAMDFTLSTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHAENAVN
HFDERETAQIARAIEYATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEAKSVADRIRCRINSKEILVKKSTTLRISASLGVSGADEAGNYEFEQLQ
SVADARLYQAKQGGRNRVVWRD
>A0A1W6KET1|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MGFTVHLPTLLLLSVAINLLIGGLLWAIFRLRSRQHCFRLWALACMTFAVGTLFAGTRAF
IDTPWITVFLAHLFLGLSPLLVLAGLQRFSGSASRKTRRSRHALRLSAACYLLILLLTFQ
GDPLNARLLTALFSAAIFIFAVYTLSKLDTTPSLPVRILKVLFTMHGVLMMSQALVIGMD
WLGLNQANTGFVLQLILVNHILLATATTLALPLLAFTHSEQRLRVMAERDGLTGLYNRRS
LFREGIRAFDQATQSQTQLAVLMLDLDHFKQVNDRWGHAAGDDALRLVARTLKNELRDDD
IIGRVGGEEFAMVLRITGDDDVRIITRRLLDTIATNGQEIDGLPLYISASIGGVEKAGHH
KTFADMMIEADAALYNAKDKGRNRAEFGRLTPETSVS
>A0A1W6KC76|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MDPAPGNHLQAVKIELNRLETYRRRTYLGVLALTVAIMMLSWAFREQGDPFITIAYPVFS
VILTILGFAFWRRSLQLRTMEITLVAVVGTMILSRLAWHFAVGDPLGEHLLLLTGGHYWA
VGIMIVGGFIALGFRGGMVTGVATLLFSGALTTQEVSQCFLAAGDHCQNWVYLLRIHLFL
TVLLVLTSAGTLLRERSWSAFARAETLHHWANTDPLCGLANRRGADRFLSAEAALADRYQ
RPLTIILIDIDEFKSINDDYGHEVGDAVIREFAAILSKTVREVDLAARWGGDEFLVATPG
VDLRSARHAAQRCRRAIERAPIAGVSVTATVGIAEYLPGQGIEDAISRADAMLYRAKAAG
RNRVITEACELA
>A0A2W0GKW4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp|TrEMBL
MQRDTFVVKQYFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALQTPLGFDVLRDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKMIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A4Q8WZ80|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKIHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A4Q2EDU6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRSFFQWLQKRSNPGLIVNSCFIVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQFGVDKALFFRNSMRDALQKPLAFDVLHQAVDRFDLLRNRPAWQLAVDK
ERTLPINGVSDAFVEKTVLLNRDDERIRNEISAALEVGYLLRLASSTVQNEERIIYISRA
GFYLSTDTPAQSDDIITRYYHLVTQPWFTQQSERNNRARAVRWFISTASSWTGNERMITA
SIPIYFEHYWYGVVAMDFSFSTMKRLLADATDDHAEGEYQLYDSRLNLIASSESPASLMN
RFDEREMAQIAHAIESDTEGGVRLGSRFISWERLDHFDGVVLRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYALQSSLQWQAWHDPLTRLNNRGALFERARILA
QQCQQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGIIASGLRENDVAGRVGGEE
FCVVLPGVALPEASVVAERIRARIDSKEILVKKSTTLHITASFGVSCAHEKGNYNFEQLQ
SIADTRLYLAKQGGRNQVIWRDDDKK
>A0A144E188|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MTSQSWRSLVHRKYQLSLRLFLFLNATSAVFSVTNPLNSVRLLSAPLIAIFSISTGLFVW
HWRKRARKINIPVVSGIFGILWAWQIVSKFALITHDHATYLLIALLTVLFIGTLAFASNI
KAFTLHSLPTFIVCLWLSDHDIWLRMTYSFALPVVAIAIHNILQTRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPTVENGEHFVLLMDIDHFKAYNDHYGHMMG
DQALKRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARLTAERIRQKVYDLKIPHL
FNESVATNVTISIGIAIFEDEDVESALEKADKALYEAKHMGRNNILLSEELQTA
>A0A427KSF6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHVAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQIRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDSWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A381KP90|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MFDSSDKGIMLKAIMVAAPILLCMGLLPVLSFYIEKMEENGRAQIVEYIAIAQAAMEVKF
DAADLNGWQTGYAFDIVRNIEGASHDDAISRSEFLRSADNFRRDIQTLRGMALSADQRSQ
LDSVQRDFNAFMERDRDIIAMYRSGHAAQRDKASKLVMGEEIQIFTHISQNTNALAVSIT
LDLMKKVAQSNSYGIVARWIMLVMWIIASAMAILLVRLLHKWLSQMRSLMQKLEALAGTD
ELTQLPNRRTWDIQIEMMLATARRYRQPIAVALFDLDHFKQFNDSYGHPEGDRLLREVAV
LIKSRMRQSDLFARFGGEEFVLALMDCNLDQAAARIESLRGNLPDQQTFSVGVTVWLEGE
RIHSTLARADKALYLAKNGGRDRVVSVEPPAPGRRPEAAD
>A0A564T534|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRIGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGYQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7W3ET75|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MPKKIMNDENFLKKAVAPGEEPPSSPQNEHQRSGLRFARRVRLPRVVGFGGMFFPIASAL
VEQPIAGWWWLILVGWSFVWPHLAWQMSSRAMDPLNREIYNLKTDAITAGMWVGIMGVNA
LPSTTMLMIMCLNLMGAGGIRLFVAGLVLMVVACLVTLQLTGIRVAFTSSPLEWWLSLPV
IVFYPLIFAWVSYQTATKLAEHKRRLQVISARDGMTGVYNRRHWETLLCIEFDHCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAILALTRQLQMTLRSSDVIGRFGGDEFAVIMCGT
PAENAIAAMSRVHERLSHLRLSCAPQVILRISVGVAPLTPQISHYREWLKSADMALYKAK
SAGRNRTEVAA
>A0A564SAV8|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHTWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQP
>A0A2G2JB23|diguanylate cyclase|EC 2.7.7.65|Leeuwenhoekiella sp|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A5K1I3N8|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MSRPAINLNLLALLLALLASLLDWTAPGTVLSLTGSLPIVATALCQLAWHHRRPALARGT
GLAVLMVLIPALASFLIPEYWISHSAWNRQVEGWTAGSLIVDWRPPLLVILCLIMLIASL
LVRTRANLGAPQLLAMTAILLVMQGVETWHATNLLSLTGSALEQAALWSLLAAQLSGVAV
NWRGHLPGLKRALPAGVLLACLTLLFWHQQKTLVEGNLHAETQAQSQRLAESLSLEIRDH
LQAMQRFANSWQLQDTLPTGGQWAAQAAPYHQDFQYFLNIAFIDTDSRIRRVHPANATNQ
RLLGRRLFDEQPAGRSALEEALSNGEMGRTGIIDLLQGEPGIIHYLPVLDDDSQRPRGAV
GMVVSLPALADTLFRQTNPSHFGLTLMTPDRTLAERQATSRLATWQHRSAIDLDGLSLTL
TSRPTLSLLLSRLSRQPVVSLTIGLLLAYLLFMVLFAHQHMDTQQRLMRRSNRELRHEVR
SRTRLQKEVEWLASHDDLTKLPNRRQFMWDLERHGQTRPLSLLICDIDHFKQVNDAFGHL
QGDRYLKSIGELGRDIIESVDGVFARYGGEEFIACLPGHDAIMARDIAERLRVAIQQIDL
RHADGSPLTISIGITTQVGGDLQTDTLLQAADEALYAAKAGGRNRVIIAPPP
>A0A1V5E2Q8|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MQDGLKSKEELLQELAVLRQRNASLERAEAERRQMESILKESEERFQVIFRSVNDGILIA
DTETHRFLAQNETMFEMLGYTSDELSAIRVRDIHPEADCPRIIQLFDDLVHKRIKVAPDV
PVRKKDGSILIADIGATVLTFRDRPCAMGFFRDVTDRKQDEEALRRSEEQFRKIFDTSPL
GIVLTRPSFFFEKVNPQFCRMLGYSEAELCAMTFVDITHPDYVMQDIEQVKRVGRGEIPS
YETEKRYIHKNGGTIWGKLLVSAIREEDGALRYYLSSVIDVTDQKQAEAERDKLIADIQK
AFSKVRRLSGLLPVCSSCKRIRDDSGYWKQLELYIQDNSEAEVSHGICPDCTKRLYPDFY
ERSLKGRNG
>A0A1Y0HMC8|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MITLAKNIQYFVDIIVSKSLCQDKTELSRLNHYVWITLLMAPVALGTSAYNAYIHNFTLS
FLVILFSTHLIGSLVFIPKMKETFLIYHISNLLYAFLILYMIFNATDTDNSRILWAYVYP
IGTIFLFGNRLGFLYSCFLLGMIILLFGIVPEIHTTYSTPFQVRFSVTYMTVAFISSWVE
YHRSRYQKESMKSHKALFLEQMNLKEEIEQRIELEKELQYLAQTDTLTGLHNRRYFLEVA
EQEFTRAVRYNGSICFAVLDVDQFKSINDTLGHPIGDAVLKTLAKHCLKSLRETDIMARI
GGEEFAFLLLHVNEEQARAKMETLRKELSSLEIPYDEGKILNFTVSIGLAMCTPEIKRLD
ELYIKADAKLYEAKDAGRNCVR
>A0A6H2CB53|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. NEB149|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1Y0N9I9|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MGLQAFCPSMQWFAAISACSATVLRLSMNTYTVRELRHTMERWNSEYALVLDEAHASNLQ
RTRLLSPLAAALNGFFAVLFLWMALSAPDDDPAYRWKLWQLLTHTGMGAAFALCAWACRP
LEHRHRSWSGRWLPVLAMAVCIGFAMLITAIDQWVTPAITPFFIACIVTSLTIFLRPHVA
AALFGVAFVLFSTLIGMTQHNPEMLLSNRINGLAVCVIGFCLSVLMWRKFTTIAVQKHQL
EKAHTELQLKQRELERLTRQDGLTGLFNRNTFVELSTNELKRAKRQGSATTILLLDLDHF
KRINDTWGHPAGDVVLRHVAQTMVNSVRSTDLVGRLGGEEFIVLLPHTTAEASRKIAEKI
RQRLEVSDIRWEGKRIAVTASIGLSGTTAEESREFDSLYTEADKALYLAKQRGRNRVI
>A0A1Y0N9W9|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MVEKRSFEIARETLKQLTARKLVPTPANYQSVYNEIAGIPSVQPFPADFLRDLSQSLPLK
TPGQQKQKGLLDYAIDRLSWDGVKSALVGYGAFAPVVASDAATSPLTSSSAASAEPPPAN
PPALTAEFFAQIARLIEYAQPALGTDDERFVEQTGLLLQAMRKPDADAFTLKTMLVNYSH
RLSFAAEDQAEIRKGLLKLLHLVFTNIGELSLDEQWLKGQMDALMSVSTPPLSLRRLDEL
ERLLADVIFKQKDAKYKALEAQDEMRRMLAAFIERLAQMTQSTGTFQSKLEESARLIEQA
KSIADIAPVLKEVVGTTRNMAQESQLSREQLGAMQERAKQTEAELAKLHKELDRVSLQAR
HDALTGALNRKGLDEALNREISTMRRNESVLSVALLDIDNFKKLNDTLGHATGDVALTHL
AAVAKECMRPQDTLARYGGEEFVILLPDTPLDKGIEAMTRLQRELTKRFFLSGTEKVLIT
FSAGVAQVVAQEEPADAIRRADQAMYLAKRAGKNRVLGA
>A0A1V4ISY4|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MDLINNRYRVLDVLYEKYYTNRYLVADAKLSNKKVCIDIFNKENMNSEILDYFENEFIKL
KNANNRGIANIFAYGNIYSYDNIEKDDTIYFYLSEYIDETMDLKEKLDSMNLEQRLDTFA
QVCCEINTLYLKGLYCNVESLDDIYILVQDNKPVVKIRDIVSMILDTWSKRPSSLNEKIL
IRNLRIIFNKLFKGYNGNETELSDLAAFITENKNESNVHSITEIINYINKKFSKEYKAFY
LEELEKLNLKNVMVGRKDIKQHIIQEYQNIVNNKAGITKVIGIYGDSGSGKTRFMNEMIH
SFSINRVKFFWDRTDMYIGEEGKTNNNFIKQLIDSVDNIYDNDYPMEINSLMAMFLNSDY
GIFDSDNSNINDVYKFISIVYRILEEAAKKQPIVIMIDDIDLNHAIYKDILKYVISKNRI
NMLIIFSYKSMNAEMEEFLSFLENYENYENIKMQYLNESETVLMVKEVLSMVKTPTKISG
RIYSYTYGNPLFIEEVIKNLFLTKKIYINKNGRWATDYNTIQDIPMPNSLKEAISSQIES
MNDNELNVLKKISLFSIPVTIDILEKVFQIDFELLSIIDDIAEKGILTLTKTDSESLYEF
SNKLMKNLIYHKLDENEKKLFHLKIADTLEKDIENNGFKYIDELIYHLEKINDNKRLLKY
YVRNAVRLEEKGIYEGSIKYLEKVKQLFLKYSEDKRVLNVFLKLGDLYRRNGYIEKAQDY
YKTCYEESCNINDTELQILALIKIATIYFNRNEIDVCDEYLSKAEKILEQHYYMQGEIEI
NIIKIKIYELRQEYLRAMELSNYTIRLCHGKMPKYMGRLLKHLGNINYYTGNISRALENY
EESIRWYEKINYIKGTLNPLNSIGVIWGDYYQDDEKSLQYFLKMKKISQENMFLDSDILA
LINIGETYLINNDYEVAIKYLDEAREKCEKFSREADIFYNYIDIAYTYLKMEDYKNMFKY
YKILCSELLEYPEQGMSLNDFYRFLSEMFLKMGVIEKAKYFSHLAVKRYGEDNSINKWNA
NLIKNLIDINENKSEEFIDRALNNIDEILDKHKSDARKAEIIYRTSYALHIKGYNEKSIE
LMKKHDFNTKEIKMLALGKYLRAVLYEKGDSIEALMESLQFCEKSKNKELQWRLCCKIGD
WNYKRGNHFYAVNYYFQAMQVIKGLLYGIENKHKVDYYNSNGMNEPVYKVYSISVNMTKN
APIKVSRHGVSDINELDRLFKYENTKSLLGNRKLIRSAREIFDKKNANGIESYKQLLSSL
QIDPIYNLSIIAKYMARILLAKQAYIIVEGYKKELKVIFTLDDNKDTVNKKDVIEMVRKT
RREILITDAMLDQDKDALEGLDIDNKVIICIPVMVDMNVASARYKNERRNIKDKLIKNIG
YVYFEADRIINNFNKTSLDKCNKLIPLVGLNIDKYVLKSNSSIDKLTRTFTRKYLEDTLE
EQKYLCDSNETEFSIIMFDLDNFKHINDKYGHQAGDEALKNICSIVLNSIREVDCCGRYG
GEEFIIVLPQTNLEKAAVVAEKIRNKIFKTRVLHNNHKATVSMGISSYPSQAHTVKELIE
KADQALYVAKKMGRNRSRVWNESFKGKAKASSKLTGIITGNATQDYRNVSVMIEITELIK
NNDKLENKLYTFLGRIIEVTESEFGSFVIINDNNVDKIYSRRMFKEGWQESEDSMFLIEE
TVRSGEGKYMIDWDTAYDKEIKNGVPDWKSIIVSPIINNGIIKAILILSAHSRNREFDFQ
DYNFVRILGQMSVGLL
>A0A0M7DB77|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MSTSSVGVAPSSDRHAGASGQACYLSASDEQAWIAVYQSVDAYTRGQVAAVVGDSLSALV
DAFYSTLLADAEAGPRLSHDIVSSRLHAGMTRWLKGLLCVRDQGDIAVLMATQKKVGEVH
ARVHIPIHLVMVGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPGLQQITDAVAQLDSVVLPQLMRGEEQGLAASMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSAFSVLLLDIDHFK
AINDQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAQQEAALATAEKLG
AEIRRHVFNIPEAGPLHITASIGVATFDGHPDYAYLIDRADQALYQAKQAGRDRAVAA
>Q0T5L7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A7L6LC46|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMNDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQACMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A5P9CNR1|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MTINLDIATLSIICVLLSVCYCIGLFLIQRLQPSVCGINTIATSLLLLSLSFFFLSFGND
VTLWLSKILANSLMAFSYILLLMGICQFRGFSVKLANVGFYSFPVLVVGLTYFTFFMPST
SARVILMSIYISTMCFVSIIANHKGKSIDISPSTVLLSVGLAIQSSYNLFRFGWSLFEGV
VDDFMHVGNVHQLAFVSTLLMIILIFFSVTWMLTGRLVATLHNTAIKDDLTQLYNRRALE
ELIPTEVARALRHGQPLSIVLLDIDHFKQVNDTYGHQIGDKVLSTIGSILKLHTRRDDLS
FRYGGEEFMVLLPNTEIEKALIVAEKLREEIENSRMLPSKKDRCTASFGVTQLRDEEWQS
AVERADVALYNAKENGRNQVIEGRVNLVSTVNGEES
>A0A7W4PT96|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVT
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3S9L6M1|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MTVDESLAQIEESLRTSPETAIKELRLLDKGNLSEQQQLKYATLVGIYHIFTADYQSAQK
SLEEVLPQITSTPERVKVLGYLATVRLILKQFPESMQAISDMLSQISSINDKDIQRNAYI
RLASLYYQMSLFEQVGVYAEKALNLAPDDAVTDICYSYLYIAASLMEAGKITRAVSAFDE
TRDYCETNKLPLIATMATKGLGWTYLRDNQVKKAIGPLQQALDKYREFGFELEIASTQSL
LAQAYLDAGEWDNAGAAADEAIDNAAADDTSLRGAWKVLAAVYARNGDFKGAFEAQQKEA
EYSTRLIDETKAREMAYQAAKFNFEEQRREISLLNSERDGYLVRQETISREHSGSLMAST
VLLGMCLFLSLFLAAGLSQRNRFMRLAQRDGLTGAFNRATGQEKGENALVRCMARGEDAA
MILMDLDKFKSINDECGHATGDWALKKVVEVIRPELKSEHILCRFGGEEFMIVLPGCSGQ
EAAEIAEACRRAIANVDTHYSGNRFILNASFGVTSLDERDLSLDPMLRRADKSLYCAKHL
GRNMVVWDQERYPPVSAGAAVSRPADEPKAQNASDSAGPAQASVPQTDPVTAEANNASAT
NNTTVATSGDKPTAVAN
>A0A7Z8ZPG9|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQSVITRV
>A0A5C6F5N6|diguanylate cyclase|EC 2.7.7.65|Rubripirellula reticaptiva|TrEMBL
MTDTTDSTVPSDATVPMAIIPESMAGYGLAPLTPLPNAHSFPHAKDAGRQIDAHISSDTL
VGNLLAELHAASPTAIELGSKNAIKPEDIQFENRLAVVRLGMATSLFYSLRTKHAPTAAH
SLRVALSCSAWAQRLGLDEATRDRIEVAALLHDLGKIGIPDRILRKPGKLTVDEQLTIEL
IPELGCEILRGSTGDTELLDIIRYANTWFDSRRHGDGPRGDALPIGSRMLAIADAFDAMT
TNTVYRPALSRERAIRELMQNAGSQFDPELAAEFSRMLEDRPEMLHGGVVDRWLRQLQGD
TPPKMWGSLGELSQSNPGSEQSASSGPATREALFYQHLFGNLKDGVVFTDAEGTITHWNE
SMQRLTSIAADAITGQSWSNDSLRLRGSDSRRDEDECLVRDCLACGNTVSRSMMIEQPGK
VPTPVQLVVSPVTGATPGIRGTVVTVRDLSDQTSLEEKLETLHHQTTQDQLTGVANRAHF
DHMLEELTAATKAGGPSFSLIICDIDHFKRVNDVHGHPAGDEALKGFASVLRAHSRDGDT
VARYGGEEFLLLAPNCDNATASKRAEAIRIALEGTPLPSLGGEAVTASFGVTEFQAGDSA
ETVLSRSDRALLKAKDNGRNRVIQLGAGNVVQMPSEEPAVGRSWFDWFKGSESTENGEFD
IVTPVPVDLAIEKLRGFIADHNAEIISVDENQVSMKLNVTYSRGGRRRADQQMAIRVQLT
LSEGREESSARRGRIRTNVHAQLQPIRNRDRRGQEVAICFSQVINSLRSYLMGELKRSDL
S
>A0A7L5X9R5|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEEAYRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQSVITRV
>A0A3S9L777|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MSSAPEHLLNSVASITEQRQLLSLATSLIDTIEQTMGVSQVAVINVGELPHFPQLLSSSG
FTQGMDPLPPCVQACVERGELVLCDLQTPCKVALPIKMNDTVVKVLLINDIDPDDTQLTM
LRAFSRIYENFARVVQESQTDSLTGLLNRKAYDARLFHLFTCIRSETRRAPYFWMLTFDI
DFFKKINDTLGHLYGDEVLLQISQVMHRCFSADDALFRFGGDEFVVLLDNKSQREVEDIC
RQLLAGAANIRHEKTGPVTLSIGITALNLEDNPVSVMMKADKALYFAKENGRNQWAFYHQ
LISHGDLLPPQIDDDIELF
>D3GRM3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O44:H18 (strain 042 / EAEC)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7Z2GE11|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia acidiphila|TrEMBL
MKRPHLVVTVCFLAAMALVSGVGLRQLYQMTRNDLHSRQRDLEVRAVGVDALISAERRRL
LFLRDYAEHVLASPSQQRAGLLDPAVQAALRNSDKLAWEVPGAMDGPLVFGTNAQGLAGI
EGFHRDAATLPADIVLARSISPLLAISQHADAVQSTVAYISANGLYVLSPERPDAPARDL
LRRFSTMPYYHLHLAGRNPAREIVWTPIYTETKKSEAISTLSAPVYANGRFRGAVVMDVA
PSRLLALQLASANLTDDEEPAEFGLLNKNGDLVYFVDGKITAHPPANFDPYLIDMARAQA
ADWMQRGQGYVQRGGRYLLFQHVGESHWMLLANTDDSELTLAAAHRVFSSPLIVAWLAIA
VLLVGTLFIVKNIFGQYVLASSRLETLARSDPLTGLANRRRFQEVFDETLERSAREGGGE
AAAPIAAMLMLDIDYFKRVNDRFGHAAGDRVLVIFADILRKNLRSAEMPARVGGEEFAAL
LPGADLATAAGVAERIRLAVEAHAAGLAHASGAPGEAAGNLDPDAIAFTVSIGVAASPAD
CGAHYEALMSVADRRLYAAKEGGRNRVVAEDSRSIDPAQA
>A0A495AFM4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. R1(2018)|TrEMBL
MTGNWVQRVISRFRRPQRVVNLCFIIVFIFSTVLTWREVVVLENAYVANQRNSLYNVATA
LDRQLQYNIDNLLFYRNTMHYALQSPISTDKSRRALAAFEISRAQPFWQLRLDTSRSLPI
SGVSDAFVNGNALLDRQEERMHDELEAALEFSYIMQHSDRIKDLQRHIFYASRAGFFLTN
TPPGNDPQIISLYSRLVAQPYFSSQSPLYNPSRRLQWTHAFDPNTENGQIITASVPLDDN
NRWYGVLAMDFPIESMNKFLREARHSEREGTVLLVDKHFTLIASSDDNPSRQTRFTQSQQ
AEIAMHMNNAKRGDEGELRMDSRFITWSKLNNFDGLLIKVHTLEESMRGEFGHISIVLSI
LWLLFTLMLAASWLVIRRLVSNMLKLQQKLTWRADYDTLTNLYSRGAFFDIALRLAAQCE
QQARPFAVIQMDLDFFKSINDRFGHHGGDKVLAHTAAMLAGSLRAEDVAGRVGGEEFCIV
LPDATLDEAAQVAERIRARINNKELLLKQGNTVKISASFGVSSAQELRDYNFERLQSCAD
QRLYKAKQAGRNQVCTAI
>A0A645GR20|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MFINKVEIDKVKYYSEFDEMTGVYNRRAGFKRLSQVNTNKTSCTISICFVDINGLKEVND
SFGHDTGDELIKTVVLGIKDNIRNDDFITRLGGDEFLIVFSGIAKDEAEVIWDRIQKYYD
EVNNKNDKKYVVSASHGIETFFCNSQEKIDDIINNADGRMYLEKKRIKKNLSVIKQ
>A0A645DN99|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MRKQDILARWGGEEFLMLLPNTKGDEATSLCEGIRKKIEGTNFVYRKKKIKLTVTFGVEE
YNESLGVDSTINNADKNLYKGKNQGRNRVVFH
>A0A822PFB5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A1X1CVC3|diguanylate cyclase|EC 2.7.7.65|Pantoea rwandensis|TrEMBL
MPISSLPQRAGHPFLRVHLCFLAVFLFSAFLTVHEALELKNNYEERQRAQLAEIQKSLDS
QFQESIDELMYYEKMLNYALTHPLDSDHAREAIARFQRLRQQNTWQLQLSSPRSMPLNGV
SDSWLAHDPLLLREADHINQELRAALEFSFILQFGDSAQDFHSRFWYISRAGFFISSRPP
QSPQELAQSYSTMIQRPYFRDQNPANSSHSRLRWTEVYQGEFNEGLMMTVSTPIVSNGYW
YGVLSMDFTQQRIHALMMQVHHSLLQGKLLIVDRSLNEITRLHAPNDEPLTQEQQARVEA
RMRQQPAGVMRLGTQFVSWSHLKNFDAYLVNIQSLRQGLSQELGRVALFLLGMWLLFVLL
LGVTHQVIFRMVRRMDMLSSQLAWRANYDGMTRLLNRNAFFEQFVALAAHNKQQQTPIAV
IQLDVDHFKNVNDTWGHAAGDQALIRVASVISHTLRKYDVAGRIGGEEFCIVLPETTLSE
ASAVAERIRTRLAAKTILVNCKATFSVTLSAGVTASEELGDYHAETLQATADRRLYLAKT
GGRNRVCAEG
>A0A380TAX8|diguanylate cyclase|EC 2.7.7.65|metagenome|TrEMBL
MRMPWPHGLPSLTTNGFGAADGQTVRPPRHTARLLRHGLLAALLLFGATAAFQLSTILQD
RADGMSRYVRVDAWAVGQLEYELQQFRSRLARHVAGDAQAPWALVAAQLNTVRATLPLLH
RSQEYEQFRLFVDVDGTAAAVGAALDRVNGLLTDRTGLAGDLATLSQVEAALAAPLIRLR
QLMVDVATVRSDLQDGDLANVRWLIGANRWMLLAFGGITAVFILLLMKEALDARRAERIA
SDSERKSRHIAEHDGLTGLPNRMLFHAHLREAIAGAAASGHDVLLLTLDLDGFRDINDTF
GHDFGDSALTAAADRLRQALPADAFLVRLGGDEFAVIRTGSGASESEDALANHLLATFQQ
PLVCGDRTVQLGTSIGAARFPVDGTDAETVMRAADLALHAAKAAGRACFQPFRIGMMTEV
ERRQDMQEDLRRAIADGELEVFLQPQIDLASGGCIGAEALLRWRNGDKGWISPGVFIPLA
EQTGLILPLGRFVMEAACREAMRWEGAAARATIAVNVSPAQFLYQDIYAEVCEVLEATGL
PSHRLELEITEGLLMRDQRAAMAVLKRLEDLGVQLAVDDFGTGYSSLSYLKQFPVQKLKV
DQSFVREIEANASDKMIVRTIVTLASGLGLRTIAEGIETPAQSRILGELGCEEGQGYLFA
RPMPAADFRSWTSTWLAQAGAQPAILALAAG
>A0A378SR47|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MRRLSTSAVVLLTFPPVFALSIVAGRATRLGGSEVALVWPAAAVAVMWLLAVHPCSLRQR
AIHVTLLGILAYGVNVATGATVSLSAWFVLVNVVLAVVTVGLLHYGRSDAVLRDPADLAR
LVVAVATGTMCAAVLATLYLTPVTGAPAWATFALFTARNGASALVGVAVWLCLRDVPWKR
PRVRPAMLVEGLVVGTIVVSVFAWSFWLNTGTPMTFMVLLPTTWVALRYSTPVSTLFVVA
AANWIIFATLSDRGPLLASDLQVRALLAQGMVFSLTVIVLALALYRDSRVRLIAELEASR
DQADQDSELLGAVLDSIHDGVILVDPADRVVLRNARADDSGLVDEVVAAARTAGHGGADA
PEPAVPHDVIVSVEDSRTLELTTTPLPRQPQFDVMAFRDVTEVRRNARELREARDLFAGV
LQAASEQAIIGTDQDGLITVFNQGAERLLGWTAEEMIGRPVTDVHDLGEMIVRADELGVP
PGFEAFIANVTPDDAEIREWTYVRRDGSHADVSLAISQMSDPDGSRVGYIGVATDITERK
KAERALAESEERFRSAFDTAPMGMFMFTVTPGDAGRITRCNQALADFLGRSTSEVPGMSV
TDLGTNENADGTEGLARLLALTDGEPVSAEVRFRRWDGDTMWGAVSASVVAAAGADPYGI
CLVEDITSRKRAEAELQHLALHDPLTGLANRALLVDRVEQAIADIGRHAPACVGLLYLDL
DGFKPVNDTWGHAAGDEVLNAVARRIENSIRPGDTAARLGGDEFAVLCPVIKDSEALHGI
AERIRREVRRPLRLRAGRTYDRLSASIGAATSGGNSNAESLIAHTDRLMYRAKRNGKDRV
ADDLVPVEG
>A0A481QKI1|diguanylate cyclase|EC 2.7.7.65|Yersinia hibernica|TrEMBL
MWWDFPITIKVMANKIRRSMDLSAVEKPAPDNKTILHITITSIVVFLFALFCIRLSEQSE
NLAPLWFPTAVLMVALFHHPTRYWSWQLLAAGIAIIVANFILYGISWFPLPLTLINLTES
AVGAWLLRKLLQPKDPLNSLFSWLKFSICTVILVPLISGLAAAWYLAPQHGNFTQVLTVW
FMSEAIGMLALGPVGLLYRRGYFNLTTKSKALFDMIWMMTASLTACYIGLIYLPFPFTFI
IMALIWASIRLPRFETFTICFLATLLIAMMINFNLFTLQADTKLSVQAFSFIPLLMVLIP
PHAMAMVMHAFRMEKEHIVESENRFRNAMEYSAIGMALVSPEGKWMQVNQALCKLLDYSQ
DTLLTLTFQQITHPEDLSADLKLLDDLYHGRIPSYSMEKRYIRRDGEVVWALLVVSVVRD
HEQQPLYYISQVEDINDLKKSEIVNRRLMERITLANEAGGIGIWELDVKKQQINWDKRMY
ELFHLPFNTPVDDAAWQQYIHPEDINRVIREYSTALAQRQPYRLEFRLLLPNGNIVHLRN
NANMICDKNGNTLRLIGTTLDMTEVRNLTEALHEEKERLHITLDSIGEAVVCTDQEMNIT
FMNPVAEKMTGWANTIALGQPVHQIIKLTDGVDGPTINNPIEHILTQRPYSSLNESMVLH
HRNGQHFDIQESVAPLKTLEGTLVGAVLVFQDVGESRAMMRKLSHSASHDNLTGLPNRAN
FDNKLKAAIQQSADFDQQHALAFLDLDYFKAINDTAGHPAGDALLKELSQLMRQHLRNSD
CVARLGGDEFGLLMLNCTLPHAKAITQSLVSMINGYHFYWEDKLYRIGASAGVTQISSSN
NQRSEIMTQADIACYTAKHSGRGQVYLYQPRQKQLLARQHELLSREDVENILSDDQLLLQ
MTPTAPPKTPLSVCFYQVSFEINRPQNMIVSQFAFEEAAALYNIQPKVDHWVCEKLLVEQ
AQAIHRKGLALAIPLSEVALLKEDFRQSLLSLIQQTILPPQSLYWMVDESTLLQYPFAIG
NFLAKLQQLGCKLIVKEFGHNLNDFELLAEHTIDYLKFNSDLITQIHINQMDEVLISIIN
GTAQRARIATLAGPVELAATLNKLVAIGVDLADGEMIGRTTPLTEVLNSGYFAIK
>A0A0A8URU4|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MSDIELRIMVIDDNPAIHEDFIKVLTTTHQQSKAFDNLDKELFGEDSRLESEESLLPEFK
IDTAEQGREGVEKIKKACEAGKPYALAFVDIRMPPGWDGLETIKRMWKIDSDIQVVICTA
YSDYSWEETVQKLGVSDNLLVLKKPFDKVAVRQLACALTRKWLLAKEAKKYTESLQKIVD
ERTESLQQSLSLLRATIESSTDGILVVDLKGNLIDCNKQFIKIWGIPKTLIKQKNENLLF
EYMINKLRKPEELSVQINRLHQHIDDTSLQVVKFKEEKIVECYSQPLRISKVTVGRVWSF
RDITERAFLEEELEHQATHDSLTDLPNRVLLNDRIKQSIAVASREGTCFAILFFDLDRFK
LINDSLGHEFGDEVICEVSKRLFTLLRAEDTLARLGGDEFVIVVPELKKGEDVVNVVQKI
LTSFNLPLHIAGHEFTLTTSIGISLYPTDGTDINSLLKNADLAMYQAKEQGGNQFRFYTP
QLNQLTNQQLEREAELRRAIQNKEFFLVYQPQYDVKNRKLLGLEALIRWQHPQKGVVLPL
EFIPTAESSGLIVPLGEWVIRTVCKQITEWREQGLSAVRVAVNVATQQLKQVNFADTVKS
ILKEHDIEPELFEIEITENVIITNLEVQRMIQKLKKIGVKIVLDDFGTGSSSLNYLKQLH
IDRLKIDQSFVKNICRSRSDEVIIESIIAMARSLNFTVLAEGVENPNQINFLKDQKCDEV
QGFYLSKPLLSESVTEILQKTTLKKEKNKKDRF
>A0A4R1N5C9|diguanylate cyclase|EC 2.7.7.65|Sodalis sp. 159R|TrEMBL
MKINGQYYDALIMSEWHDLIDITGAAAHSLLKSLSDDDISLLVDDFYAYMLDDDDARLFL
SNQLVKDRLHATLLNWIRQVLNSSTADLAELIAEQRKVGNIHARIGIPIDLVARGARRVK
QSLYSRLRREKMDPALCYDAMRFCSLAMDTAIEVMTTAYSRTHESTTKDQENYRLFSILD
NVNVERERQLAALLNWENRFIYNVATGSPAVEIQELKESEFGLWFQHKGRHVFAQVDEVS
EITALLGSTDEFIKTFTPDMIAIAEQRYVLLRTVRNRIMKLTSLLSSLFEELAKFENGKD
PLTNLLNRRFIPTILRREIALAIRTNTSFVVAMLDIDYFKKINDKYGHDAGDAALKNIAA
ILYESVRSSDYVFRYGGEEFMLVFVEITENQANLIIDSIRAKIAGRPTYPTAGEKIDLTV
SVGLCVFDGHPDYERLIRRADSALYEAKQNGRNRAETYHPKG
>A0A087BMD8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium minimum|TrEMBL
MTRVLIVEDEESYREPLAYQLTREGYEVASAGTGEEGLEIFTRGGVDMVLLDLMLPGLDG
ISLCRRIRGQSRVPIIMLTAKSTEIDKVVGLEIGADDYVTKPYSFRELLARIRAVMRRNS
LAADQTAEGADDDLPLRCSRVSMLVGQHEVRIDGDAVFFPLKEFELLEYLMRNKGRVMTR
HQLIDHIWGSDYVGDTKTLDVHVKRIRSKIERDPAHPAILTTVRGLGYKIDDPQ
>A0A1C0B8B2|diguanylate cyclase|EC 2.7.7.65|Aliarcobacter thereius|TrEMBL
MDNNIVLGGRVILDSYILNYQKEILIVVLFIFIMIYLYSKIKYINKIEHINKELILISSI
DYLTKINNRKSIDYFLNENIKFFERYKENFSIIMIDIDRFKNVNDIFGHLIGDNILIEFS
ELIKKSIREIDILGRFGGEEFIIICRKTQIDGALKLSEELRKKVAKHNFLVVGNITASFG
VANFSSKDNIYTLLKKADTALYLAKTNGRNKVELIR
>A0A5J0NH06|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Telelkebir|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3T3EXU4|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2T9Q8N8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A655TZT7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIELNRIEELFDNQQFSLHELVLNELGVYVFVKNRRGEYLYANPLTLKLFEADAQSLFGK
TDHDFFHDDQLSDILAADQQVFETRLSVIHEERAIAKSNGLVRIYRAVKHPILHRVTGEV
IGLIGVSTDITDIVELREQLYQLANTDSLTQLCNRRKLWADFRAAFARAKRLRQPLSCIS
IDIDNFKLINDQFGHDKGDEVLCFLAKLFQSVISDHHFCGRVGGEEFIIVLENTHVETAF
HLAEQIRQRFAEHPFFEQNEHIYLCAGVSSLHHGDHDIADIYRRSDQALYKAKRNGRNRC
CIYRQSTE
>A0A423P6K0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLDPPLWVWALMFFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGSRFLLAG
SAAQLLGVGVGLVVFAPAFVPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFAILGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKAGGRNRVICNCDGKPRRTLLDSV
>A0A0I3VSN1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A653Z7P2|diguanylate cyclase|EC 2.7.7.65|Halomonas titanicae|TrEMBL
MRYKDKHQLAAEWQALLERTPKPLRQAVETLVEHHGQSFADHFYRVMLEDPHASLFLSND
QVEQRLHPSMQRWLKAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLSGARQLKQVF
YQQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIAAQQDIATLPRLSNSDFGLWYFHKACHAFEGVPEIATIS
RHIQQVDREWLEVLMHEDASQRLKALGEIRDAARTVLMLLDNVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A1C6FRT5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MESCSQLYIRKIIDSILNNIKQRHNNILFVKYYNTLNLRESELREVFETQDDDICFLYHE
FSSKYMHSVFEPFLDWIMELYQKFYSDVAIDEFLEKADVYFQARSVIKSYIETGECQRDE
DLIFAEYEYEAKRFTKSVYNILEYVSKEHTLFLLLNKLHFAEQSTIKLLIELVNHNKENI
ALLANYNEVYDVPEYTKKDWDTMIDYIDSNNMIVDWSLQDGHASESERVELFDPIPKDIN
PYVRLINNMVSCVMIGQANYYLEQIHNKFEIEKITIPLKDKLSYLKLYSIVALCLDNSTT
ALMLCDNINNSIKMTTSLEERFSCSYISALIQLRYGQKETSNKYIQECFDLSDEIDDEEY
KFKAKLLDYIITSNCWKNIYSWDVNLIIDENFANDAIKYKYYNHLAYIYLFGTCNDILYF
VNGTDGIENAEYFKRGMALAKKINNESIMINAWQKNVMMASSYGYFSLVDYFYKKTLEII
EGQNNKFEESNVYNGLGYNRIVSEEYDVANKYFNKALGILYKLNNPYRICETLYNMATNA
ILAHEYYTAINYLTIVIELLDALDEHQMRICNLGKIYGFMVLCNYYLGIEYNANLYFSKL
ERSVSHMLEKPVESSFYLWDDDMFFYFFTAGLIAKDDDIEKAQKYFDRARIHLFRSTGNL
FFSYYQFAIAQYDLYEIQGRHKEAVEILNDALDFCETHNYQFKAEILRAKLEDRTLPHKK
FDLKLESVTQKQLELMSKRCKIEHELSNKNKGINFLLSWQDLLNKDYSTDKELVNSAMNN
IQNSYNIDCALFIEMKNNSPKISYKSKSISLTDKDIQTITNFFLDYRKEFITSRFDKTFD
DYDCILNIFGKINVASLMCIPMYINEVLKGVMISIVKVHENLTSNIHFFGNTDLIIFKFA
AMQILDAVERLNAKIEIKAINAKLQKSSVTDLLTGLLNRQGFAKKLEDFSDYSTKQNFEE
QETTILYIDLDNFKYCNDTFGHDIGDLMLKKLSSLFTEIVGDKGYCVRYGGDEFIIVLPG
SSTEFGIKISKQIYKKIEENGYFINDIANALKRPIEIDAQHRISCSIGISTSQKYNQESI
MECLKHADSALYDIKKGTKHDFKVWQKVQK
>A0A128GFL3|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MVFPAIMIVVGIVFLIGGAYLIKSVLQQTSHYRWQWLVYLVFIGAFILSYSASIFYGLLV
DPHCLNYFYGSVFLLGATYVYLSCRLMTKTIQKMEVMDDLKNRYELLRHHVKYDSLTGCH
NRETLFEMLNTRFQQIKSSDGWVIVLFIDMDKFKAVNDRYGHDVGDNTLAAFGQLLRQRL
RKDDIVARYGGDEFIAVMEHISLDEAKKIAENLITVAKQSFKKGILSKLNLGCSIGITQM
NPHSASVNSVIKEADLACYAAKQRKINGSVCVYNPMLATRNDTIDLGIHQIAE
>A0A069Q6A5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0C6F2L5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MLACPLPPDEALRQQALDDMALVDTPAEHYLDALVELARETFGVKTVLISLIDHDRQWFK
ARIGLDAEQTPRDLSFCGHAILASEPLMVTDASRDPRFHDNPLVTGPPFIRFYAGEPLHA
SNGQAIGTLCLIDPSPRLLDLREGRQLNRLSILAEGYLQLRSLTEHTRFLRQEIDREQRK
SLLDPLTQLWNRAGFHALHQHELELARASDQRIGIIYSDIDHFKRINDTLGHRAGDSVLR
EAASRLRAALRPEDLLARFGGEEFVAMVRVRETTELTMIANRIRELMEATPIDCAGTSVP
VTISAGCTLAGSGEEPERALARADAALYDAKRAGRNRVVSV
>A0A8F8WCN3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPV
>A0A418Z7V1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mbandaka|TrEMBL
MNKEFPLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKGNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F8WGQ0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPETPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>A0A8G6LXD3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFLNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2S2CB07|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MLVIAVVPAAMIGGLLLKQQIDVEKNYQTEQLKRLSNTIGQEINYRFYVLSTSLDVLSRD
RLLVQGIDNFFLSSHVFATLESLVDNAPLVKSAYLLDKDWDEVENYNGISGIESLKNIQT
HLLKQTRLSKNLKGDQWIFNYYDEKLMPNKLNPSERGIVVVVPVYQSTLTEGLKKDPLGY
LVVVIPMESLGKMIKPYLSNGEWVELNRNTIDSILFTAGESEHNAPSMSLQRKIELNNEY
VAEALNYELIVYMDREYKGDQFTQSLKIFTILSLIAIALGLFGAGMTYRWVSQPLAALMR
IVREYSRGNYSVPKRNLRFMEFYSVDNLIQEMSSTIQAQVKNLAVTNQALTNAMKAQEVA
NVQLSNFNGKLEKKVQEKTEALSTSLKREERRREMMQSLIAFFSKVQTDDFRDVVIQQLK
ELYPDAEWALKFQYDHKDWSYEDLPLHKLEQLELLQTDQDYFNYRSNQLYHGFNLLDSDN
KSLGLLIMQASDLQIDDFEVISIFANQLASTLEGKILNQELKRIAITDSLTELANRKAFD
IDFEAYTKRLKRYPERHFGLCIIDVNGLKQANDLHGHKMGDALLISVGNILVSACRNTDK
VYRLGGDEYAILLEEGSVAACERLTERLRCERNKHVITTENNQIIKVSFAVGDSCSVSTC
VSTMFHVADEAMYQDKMACYAKNKD
>A0A168NTH7|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSHFDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKTDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSDGSEYKNTQALLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHSGHPDYNLLLRDADSALYVAKRNGRNCVKMHEGDGN
>Q1Q7M5|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MLLNINKHHNGKYSSNKNIENSTREGAFSLYLLYLLNENLNLSIKIEELFEYTAIFLKNN
LCIDDFCFMLNNGDNDELTIFKTGSDIFEAVKDVTFKKGEEYTCIAAQTGKPFLLNDISK
KKDQFFYKGKLENIGSFLSLPLRSKNNRMLGLLNIHKKEINAFTEEDMELFITVALNIAN
TIERIELYEKAEKGAMYDDLTMLYQRKFFFDSCHLEHSKAIRHNLHFSIAMIDIDHFKYY
NDTYGHLFGDEILKKLAYILKSNVRYSDIVSRYGGEEFAILLPGMDKNSATLVIDKLRDV
VKRILSLEVAEGKVECVTITAGVAGYPEDGNSVKQILSVADKYLYIGKSCGRNRVINNTL
DDQPFHQNVKKTKHSSLLSKEEVNLLLYKNVNRRISRFKTLLRVDKGVNNIQCFEIKVME
DDWRICVIGDIGKGGFKGDLDFKPKLDEIFTCRVVVDSEVYLPAIFSIRIAHEKIIHKNR
YEIDAEIVDGHNNWKYIFSLLTNNK
>A0A2I5HC28|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCAPMIGILVLSVLLLVW
HGKYGQKRVNLPFISILFGGLWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLHSLPSVAVCLWLNGHEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFTLLT
ERETLNGLSLLDPLTGLYNRRGLQSRLDTLQVQDSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTAAEPQQARATAERIRQKVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDTI
>A0A5S9ND12|diguanylate cyclase|EC 2.7.7.65|Zhongshania aliphaticivorans|TrEMBL
MVCTGGEEYIVLLLDSGRAATIELANRVIRSLFEQYIPHSSSPITDRVTVSAGAATSEIN
DKTTAELLITQADNALYTAKHKGRNQVSY
>A0A3U1D961|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A3V8VR66|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agama|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1B9QME6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPSGSSKQWSAKVVSFLFFLAIVSAIEFFHAKQLTFLKNESYSEGKKQLSIIRSRIEAAI
VSDMYILNNFSTLVTINPDGEVKNWDKIAENIIQDGFHIRLIGLAKDDILNFVYPMEGNE
QILGINYRDYPNQWESVEIARNLGNTFIAGPFELFQGGQALITRTPIFRDPPFNQDYWGV
SSAVIGLDELFEDVGIGKIENKYELAIRGANSSGKDGPVFYGTQDVFDNAFATEQVSFPY
GGWYLALSGSEHVLMDVPWYRVQAVRLVGYSIMLVLAIAFMTIYRLYLIADSRSMHDELT
MLPNRRYFMYSLKQAFKTTQKQRARTFAVVNIDLDGFKAINDTFGHAAGDQVLVECAKRI
KSELRGSDIVARIGGDEFLVLLPRIIDDQHVSSIVAKLRKVICTTPVVYETHSIYLRISV
GWVIHNNNYDDVDALLKAADEKMYEQKRQVM
>A0A0P6Z272|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MKKDEFQKSTANLKKAVPLMMKNRVSTTPANYALWYTYVDNAIPQLTKDMDGVLEHYGIC
PPAVGEQLYNNYVASKSETNINDLRANLELLVSEVSNSMNDTLTDTSAFSDMIDQSFEDL
ARVDNESLSIDEVMSLVRQLVSESRHIRHSTQFLNSQLHSATSEISKLKTQLVEVQKDAL
FDSTTTLYNRRSFDRDIETLCEAKESLCLILLDIDHFKNFNDTYGHLFGDMVLKGIARKL
KLSCREGISAYRFGGEEFALIVPNKSLRIARQLADTNRRSLEKLSIKDRRSGQQVGSITA
SFGVAELEPGESAQSLIERADKLLYEAKSLGRNRVMPL
>A0A8F4WY92|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MSDDAQRWKEKYLKSIEQQEKLERRWAARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRD
VVRTDDMDAALAALLPRLEKAVLDSEQRRETRVDQISTALTSLVTQLQKLPLPREVARPL
KTFAKQLDGRVGQAREIPLLLSELSGLQSQALNNLEPDSETMRSGPGLLQRLFGSKDFAN
ETVADEPVPSPAAPLPVAKPVAEPQQPEQSEELTQALRAFSPQPRAPVAPAVEPDAPAKV
AEASSETFVYEAPAQAAPVDELVAPLARVEPEPEPELQAEQPAPESALAAFIETSELQVE
TPDKTVIGSLSLPPVLEVEESDPDELQSDGVYSLPDSPEPSYSSVAKHIEDTLLGLLEEL
ALPERHQPQAEAMRERLAHGLNWYELLPILDDLAVLMLAITDSGQHEFEAYLKQLNERLE
AFQGHLQVASDGHADSRSAARELDTQIREQVDGLQSSVQEAADLDSLKHVLESHLEGLLG
TMDEHQQQRDQREQETAARLKGLAERVANMEQEAQGYREHLEVQRQKALIDPLTGLPNRA
AWSERLDQEVNTWHQRGNNLSLAMLDLDHFKRINDGYGHLAGDKVLKIIANVLRNRLRPT
DFIARFGGEEFVLLMPDSSLTDALAAGEVLRAAIEACPFHFKGEPVTITVSMGVAQFQPG
ERSDLALKRADAALYRAKAAGRNQVQAA
>A0A1C3ITZ4|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MNQASESEIVIRRLYQITNDYRKGFDIQIAQLLIMGLERFNLDIGILSKVEGNTYLVEHS
VTPEGVELNSGDIFDYRSTYCEITCKSIGPICIEHCGKHDKYATHPAYQSFGLESYIGIP
IFVNDELYGTLNFSSPAPYHREFKEFDIDVMRLMASWIEVELVRRQQERKLKELNEKLEY
QALYDPLTHLPNRRCLFKTLNAEVEQLKGSLGKGTLAVVDIDFFKQVNDTYGHQMGDVVL
KKVANVLSNNTQEGEFVARFGGEEFILWYPNKTPSCVEDKFMTLLQEMKKITLDRKPVTI
SIGACHFELSTGDTKGERMSALDKLIKVADECLYIAKQNGRDQFISRPYHQERSGI
>A0A239RTI7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFSRKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A3Z6QNF6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5F1J019|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHAT
GDQVLIEVAKRLAEFGGLRHQAYRIGGDEFAMVLYGVQSESEVQRICTALTQIFNRPFDL
NNGHQTTMTLSIGYAMTIEHVSAEKLQELADHNMYQAKHQRAKKLVK
>A0A3Z5HIX1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0E2GL77|diguanylate cyclase|EC 2.7.7.65|Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788|TrEMBL
MNEQCITMLAEQWKDICGQYSATDLNYTAQFIQDNSFLLVDEFYKNMMQEKEASYFLSDE
IVQSRLKTTLNQWLLDCFNMPFKQNYEEVVQRQLVIGNVHARIGIPSWLIMRGIREIEKK
VFSLQASRTQQNIYTVTNYIVQSIGFASEIMCRSYEANIEINNDIKHTYRLFSAMQDVSI
QKDKQRSSLLDWENELMFKVFSDSASFNHLLLSKSEFGLWFIHKAAYAFSGTDQVQIIID
RIYEVDKLNLAVLKSQDKANAIALIQQIREKNREIQHLVDQLFQVSE
>A0A3V7EW34|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2T6X0D4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377PFV0|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MKRSEVNTGSIKINKFVIFSIILLVVLFVLFRMFGYIRLPALEALFPVSTSVTLILNVLL
ALFMLMKFSVDRKHLYLVVLAFAYGISSLYLMSKLLSYPGVIFTEGGIGTNANDLAIYFI
FRSASMAIFFLLSLVVYRLWNNRFINMVSVTALCACLTIILLSTAYFVSSHSSVLSLPIV
DEGSLSYQQFWNSSVGLYLVLLWGGTTCAVMWFAGVKNNFWASLSLSCMAFLGSTMLLSG
SEYLTSLAWYGAHLFEVLATFVVMLAFLFDIFKLYQKARIDYKISYNNSIRDPMTRLYNR
SYYYDSLVNRMKSASKNSPITLLVADIDHFKRINDIYGHITGDRVIQYVAKTLQDSIRKT
DIAARIGGEEFSVMLDGVSRDDALEIAEKIRVKICHHQDSPFGQDVPERITISIGIYTVM
DNELTAEQCVARADEAMYQAKQEGRDRVVIYSARTTQIMRRENSVPLRVIYT
>A0A0E1NLW9|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVGSVLYTQNAPLWLWLMLVLNGLVWP
HIAYLLASRSEQPFEQEIINMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFKPETSPLQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLMRIQERLADLVF
TQAPPLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A612JHS9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDCERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C3K295|diguanylate cyclase|EC 2.7.7.65|Orrella dioscoreae|TrEMBL
MPYQSAPTELLATTWRRAQARHEPGTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIAFNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLGDAPVAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENTFVYEIAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCAAIRFLLESLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQKASHLSVLSIDIDHFKGINDQYGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQAIAIGEKLRRRAELERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADTALYGAKRAGRNRVLANSAL
>A0A5J0T375|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5X3FU71|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRIRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A486T798|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VSRMPFENVELLHSRGGAA
>A0A095KBI7|diguanylate cyclase|EC 2.7.7.65|Burkholderia pseudomallei|TrEMBL
MSTVFTAHESPRVIGTIARLYTACLLIGFALVPAFLIAYVRFFIDPRLVFENHQFHELAI
AAATLEGLFVTYVTWRCYLASGEPLLRWLTLGFLGFALIYSLHGAFTGMAHQNIWLFLLY
GPASRLVMSILLLVGQLSYFRDADPPERRTHLSMWLPWIAGYVVVCFAVAAIAYSPIAGH
LWTRASMEGGAMIVSLVNVALLLVRRIRTPLMLVYGISVTSFALSSIAFILGKPWNHMWW
LAHAVFAGGFFMLSFGVVQALMTTRSFATVYSQQDLMARLAESMARTEGVLQELKRTNQK
LEHLATTDPLTGASNRRKFIEQMQSEIARAKRDGTAFSLLALDLDNFKTINDNYGHQVGD
VVLRNFVRQCLAAIRPYDHIARVGGEEFMVLLPRMLADTASGIAERVRTTIANASFGIDG
KHTPVTVSIGVSQYGRDGDTVDEILSAADKLLYRAKNEGRNRVVAS
>A0A0K3R646|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGAIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A827S3G3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAANPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKHGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X7C9W3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3L5HA91|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A0K4SH17|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>J7Q938|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A3Y3V3P6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQRRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALSLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A828NK35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A370V8C2|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A7D7DUY0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQADPLIRDKAAEIAVAHAHYLSIEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRMLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEMDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFKQTMRNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
MKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1V3VVN7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAVDIAMYQEKKHKQKTPFVAHPALHS
>A0A370V6U8|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMNDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQASMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A854BY39|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLFHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRAHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQQADAHIERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIVDEQTFRRSFGDPALNHALDRRVLHEFFQQTAKAIASKGLSIALPLSVAGLSSASLV
NELLEQLENNPLPPRLLHLIIPAEAVFDHAESVQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNNSYFAIN
>A0A1U9TT29|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNSETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A853SYI1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MLPLHRNSLIAAALALPLFLFLYATLGHVKPFAVWKWMDIVCEGGTAVMAGIWFLFTLSS
RPRGRVTSLIAGGLCAIMLGSWADCLDEFFAIDKQEVWDNWLEALIPFGMLVLTIGMYYW
RQEQFRLNEHLQKRERLFRDHRAFDRITQLADASYLRTQMRLEQERRPGLDCALVLLDID
SFHLINREYGHREGDRVLQAVGHMLLLNLRNDDLLCRYAGDRFAVLMPGVSREDAAVRAR
HLCVMVGQMRHHTNDNREIRLSLRHACSLTDGVPEVVLAELSRAVETPGRSASPRAGSAA
PA
>A0A3Z9KSV1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKTVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A853T6F2|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MWTKPVPRMNLRRLIVLVAFASALVSLANTFYASYSVQRQLLIDTTLEANHAYASKLAST
AEDFLQSARQQLAYSAGSLPSRMGDEQWLTDEAQRLRLQTNSFNSVLIVDAQGKVLGVSP
ETLALKNRTLDSAGAAQALRERRPLVTQPYISSVGNLVVFISHPILGKDGRYLGYVGGSI
YLKQKNILYTMLGQHYYRDGSYLYVVDQNRRLLYHPDPERLGHVAGRNDVIDTIIAQRGG
GNRRMHNSLGVDMLAGYAVMPSTGWGIVAQRPTAMTLAPLNQLMANTVWHSLPIALLSLP
FIWWLASLISRPLMQLAEGARRMDVPGTSEHIASIRAWYVEAAQIKKALLKGLALLQNRI
GKLKTDVETDPLTGLSNRRGMAAALDVWQAQARPFSVIAIDIDHFKQVNDKWGHAVGDEV
ILRLAQLMRACSRDADVLCRNGGDEFIMLLPDADLDVAMQVAERLRAKVAAAVIPGAGAI
TVSLGVVASSHGERSTDAVLLAADAALYVAKENGRNCVGITEPA
>A0A0K3QA84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRARNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFIS
HWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDL
HNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7H9K481|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MFKYKKKAAGICFLYFLCVSVVTCYLYTMYVKDRVNSVKVSIIDSGLAIANVSEYRRSVS
NNVFYELEISPDELLNKIRDSFSNFQHPGYLYDLGPYMISDDKCIKITSKGDDFCDDIVS
SVRVINEFERGVISLKDKYYVYYAHPIAKRTSLISVVDPERYLSLIRNQSGEREDIYVSF
YDINDNEKKIAGDDFLINDAVFEISAITLTYSYIPEMIFIVAYKKSKYIYMCLLFVFASA
VSAVIIYYYYINLLQNIIYKGRLEKESILSDHHYGLRGENLFFNAEEINAIREIYDFGTY
DALTRASGRRSFDKDIKILSEKFGYLCLFDIDKFKTINDKFGHLFGDEVLIKIVNLIKDE
LPRSKGEIYRFGGDEFAIIYHDKDVSQLTRTLHRIVHFSMGGLNCSCSIGVANTDECMNN
IERLKLLADERLYKSKQNGRAQITWC
>A0A2A6Q3E8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQRRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSNNYWYGVLGMNIPVRTMQQFLQNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTHLYNRGALFEKARQLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRALDVAGRVGGEE
FCVILPGANLAQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2U9LBL6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A828M1B6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVFRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0D8WE21|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A376TEP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A641HRA3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1C3PJ49|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIQAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEIQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKSAFRESDILA
RQGGDEFIILFANTSRHDAAAAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A735RGD2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 48:i:z|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A737JVZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi C|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X3GBV8|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MQHSGRKLSFTAPIFISFAGIILSFILIASLVTVIQRNDTIRDYHNINRNFTHNLAVNYT
ESILHENDYILGRAATYLARNDELNNIVNINPDKGLQTMMQLLSMMPTVSSLSVADTSGH
YLRAPQAVERPDTHAFDATSRPWFVHQGDVGIFSRYTQPYIDFFTKQQTVTLSKPVISAD
GKLKGTLAFHFDLSAMSHTLRQMKSPVPGEFFVVNRQGQALLHPDSGKLFQTVVSDKLLT
GMTAGEGEFFDKPSQTWYYYYSFTNPDWFVIYKVSDETMSQLAQHESIIVSWGFALAGII
IITFGLYLRHASRGILMNIINAIKTGDTRHAPGIEVMLHKAIETNKERERAYVRQATVDS
LTGCKNRWAFDTDISTLMNEHQPFALALVDIDNFKSINDTWGHLSGDIVLRNVAREGITI
LQTHGLSLYRYGGEEFAIIFTAEHVEQAGALLELWRINVANRTWREEGLNVTFSAGLGEW
HMETLEHLVSSVDEALYKAKRQGKNRILRTSIT
>A0A3R0XPP5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5Y6G9Z8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSALEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A344SEC1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7U8KCG2|diguanylate cyclase|EC 2.7.7.65|Brucella suis bv. 3 str. 686|TrEMBL
MTARILVVDDVDSNVKLLEARLLSEYYEVVPAYSGAEAIEICLDGQIDIVLLDVLMPGLD
GFEVCRRLKANPRTANIPVIMITCLTSPEDKVRGLEAGAEDFLSKPVNDLELLSRLKSLT
RLKMMSDELFQRAGRIADAEVDALLARKMAGKDGNKDEIARILVVDEDELAAARLRHILD
ENYRVDVASDAETALIRAIETDYDTIIVSASFTYYDPLKLCTQLRTIQRTRLIPIILMVW
EDEGALVVRALELGVNDYLMRPLEKIELFARLRTQIKRKCYNDILRQSMERTITQSVTDG
LTGLHNRRYIDMHMPLLLTRAIERKQPLSIIMIDLDHFKQVNEQYGHGAGDHVLREFSGR
LRRNIRGMDLISRYGGEEFVVVLPDTDRQAAFNVAERVRGIVAEAPFVLDDGKRRASLTV
SVGVAALRPAGDSLEALFTRATDALIQAKQSGRNRIVLSAA
>A0A743JF17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVSHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A603AWN7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGGYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>U9XYE6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 113290|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>N8WQZ6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. NIPH 899|TrEMBL
MNNECMAMLAEQWEQICQNYSSDDLLHAFQFIQDHSLVLVEEFYKNMLLEEEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
MFELLSLNPQPDMLTTCSYIVQIMGFTTEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDTLNQAVLECTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDSDERRALNIAENIRKYVEHGLISMAQGQQFRLTVSIGCAL
FDGHPDYQRFLDAADAALYMAKNTGRNRVYLAQPSQIQGAQKASV
>G4SXU1|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MGIERQKILIIDDTPANITLLGMALKDHYEIQIATSGKKGLELASETPPDLVLLDIMMPD
LDGYETCRLFKADERLRHIPIIFVTALSEIEAEIHGLSLGAADFLIKPFNLQIAQLRVRN
LLETERMRQALRQTEEDQRLAATVFAYSHDGIVITDVENRIINVNNAFSRITGYGLDEIK
GENPRILKSGRQDTEFYQNMWQALLSEGHWSGEIWNRNKQGEIYAALTSIAVVRDDQDSI
HHFIGSFIDITPIKEHQHALERIAHFDPLTGVPNRFLLSDRLEQAIVHTRRSRKLMAVCY
LDLDEFKPINDRFGHQVGDQLLIEITRRIKACLREGDTLARIGGDEFVLLLLDINDRGEC
KTILRRILKAVSAKMLLANQYVSVSLSLGFTLYPDDFSDTETLIRHADQAMYQAKQQGKN
RFQRFDMLQEKHAYEQGKQLARIECALANNEFVLYFQPKINLRDGAILGVEALIRWQHPA
RGLLSPSMFLPMIQGSQLEINIGDWVLSTALSRWNQWKKAGVDIAISINIAAGALLHPDF
VENLSAKCAEYPDLQSGCLELEILETGALDDDERAIKVMKACQALGVVFALDDFGTGYSS
LSYLKSLPAKTLKIDRSFVLGMLENEGDLAIVKGIIDLASIFKMQVISEGVETVAHLLKL
LELGCENGQGYAIAKPMPEEDLLNWLKEWQLEQKNYLKKAFHHEEHED
>A0A853HGF2|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MRSGIAPDGNAYADYVVMIKKKNKQELAATPHPLLRLVSLGLLTYIFTLFSLELTLFDTL
LAPLWFPTSIMMVAFFRHALRLWVPIALVCGAGTVLATLTLFPPGHLELSYTAINIVEAL
VGAILLRKLLPWYNPLKNLNNWLRLAFASAVVPPLVGGLLLAAISEGHVTLRLALVWILS
ETIGALALVPLGLLFKARYLLRHRSPRLLAESLATLCVTLLCSWLALHYMPWPFTFVIVL
LMWSAIRLPRLEAFTVFLATVMMVSFVIATNPALLDLPHQGMVVNAPWLPFLMILLPANV
MTMVMYASREERKLITESETRFRNAMEYSAIGMALVSTEGGFLQVNKALCNFLGYTPEQL
AHMSFQQLTYPEDLHADMEQVEKLLNGETNNYSLEKRYYTRAGDVVWALLAVSIVRQRDG
SPLYFIAQVEDITELKRTEWVNKRLMERITLANEAGGIGIWEWELGTDVLAWDQRMFELY
EVPPHTRPTYQLWKSRLLKEDVAHAEATIQEALRARMPFKLEFRIQVKNGVRHIRALANR
VLNKQGEVERLLGVNMDMTEVKQLNEALFQEKERLHITLDSIGEAVICTDVDMNVTFMNP
VAEKMSGWRQEEAIGQSILTILRITFGDNGPLLDDIHSGEATHAGTGIEQDVVLHCRSGG
NYDIHYTITPLSTLEGENIGSVLVIHDVTESRKMLRQLSYSASHDALTHLANRVSFETHL
KRLLQSVSDTHQRHALVYIDLDRFKAVNDSAGHAAGDALLRELASLMLGMLRTTDVLARL
GGDEFGLLLPDCSLENARTICERIVAAINEYPFVWESRLHRIGASAGITIIDASNNQAQD
VMSQADIACYTSKNAGRGVVTVYEPHQQQLHSGRGTLTAQEQQRMINEHHHVLMVRPVAS
PRVPESASFWLLSLRLWTSEGEMIEEHSFRAGLNAPELMQALDTRMMTDFFRDHAASVAQ
KGVGVALTLSGATLLNAQRLDALLAQLAASPLPPRLLHLVIDSDVLMQDATQARRQLARL
REAGCRVVLSHIGRELEVFEHLSASCADYIMVASDLVADAHASLMDEMLLTIVMGNARRL
GLQTIAGPADQQSLLETLANVGIDLVFGETVAQTQALSARLATSYFAIH
>A0A381H139|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MRFRRISNPPGNSGTTACCRKTARRRKRSSASLWRRVSPLSSNSGLGVKDGIRHIRALAN
RVLDKDGDVERLLGINMDMTEVKQLNEALYQEKERLHITLDSIGEAVVCIDVDMNVTFMN
PVAEKMSGWQQEHAIGVPLLTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGR
YDIHYSITPLSTLDGGNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLK
EILLTVRDTRQHHALVFIDLDRFKAVNDSAGHAAGDALLRELAALMLSMLRSSDMLARLG
GDEFGLLLPDCNIDSARFISTRIVNAINEYRFTWEDREHPIGASAGITLINNANRLAADV
MSQADIACYASKNNGRGRVTVYEAQQEQAHSERKSRLRMSNGA
>A0A1V4X7I7|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaB.Bin038|TrEMBL
MPAKRPEKTTGGRKKKRDGPSPGPKAHKRAGKDGAAQRSTAKPPAAASRPREGGDLYGSL
FRDSPTVMLIIDPTDGRIVDANRAAVRFYGYPARMLKSMRISDINLLDERSLRAKMTQAA
REEKRHFRFRHRVAGGAVRDVEVASGPILLGGRKLLYSIVLDITERRRAEEALRDSLETA
GAMLNAVTESFALVDREGMVLAANETFAVRLGTTLDRIIGASVHEHLDPELVKSRKKRID
EVIRSGKPIHLTDERAGRWLENSIYPIFDSRGKVGRLVIYSQDVTERRRSEEALKQSEAL
LKSILQAAPIGIGLVYNRVLGWTNDQLARMLGYAVEELAEKSARILYDSDEEFERVGLEK
YVEVLKGGTGVIETRWRRKDGTMLDILLSSRAIDPRDLTAGVVFTALDITDRKRSEEALQ
QYQDELEQRVLERTSELMVANQALILEIEDRNRAEKALRDSERRLADIISFLPDPTFVID
RDGRVIAWNRAMETMTGIEARDMLGKGNFEYALPFYGERRPMLIDMVLSGDESGAGPYAR
VRRRGEILFGESYTSSRASRKQRLYLSGTAAPLYDSQGNRVGAIESIRDITERKRAEEQL
RYRDAILEVAGFAAERFLKAPSWETDIREILARLGTVTGVSRVYLFENRTSEGGILLTTQ
RYEWVAEGIKAEIDNPVFQDLDMEREGFARWMEVMRRGGHIYGIVREFPESERGLLQSQG
ILSIAAVPVYLGDRWWGFVGFDDCAEERAWSEAEMEALNVVANTLSAALSRRHTEMRLIQ
TSERLSVVLESLPIVTFTSSGGEEERITYITGTVEELTGFRPDEFLRDPGFFLDHVHPDD
RPVVRSCRMGSARRERAAASSGSAPRTGPTAGSPSTAASSGAPRGRSATLWASGRTSPRK
SESSRSPTPACSR
>A0A2D1QJU6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MPEKRIHIVTRRLQWLLGSLVILLLALTFHQTLKQVTELNERDTLNIAARLRSQFQQMET
VLEAMRGQAEERLRSNPQSALTRQLYQALHTDPELGFSLDKVPANLPAGLSGNLTGLGRL
PAPGSEREARLHLALSLSPLLSTASKLLGDKVAWVYFTGVDDFIYLYPWIPSSEFRFHRA
IYLKSYWQDALKQQNPSQRAIVSRPYEDFAGMGQMISLSQPIVKDQTLVGVISIDVLLTR
LDRLLHESTPAIGSLFLVNQYQQILASSAQGADFVPKFQTDRHGYQWRQGALQLVQTIPD
TQLTLIHRIPLTALTQALFWHSLPSLITILFMMWAALSSLKARRLNRQLDYLSSHDALTG
TYNRHYFDEFERLHLRAKAREVGVVMFDCDHFKQVNDRFGHEVGDQVLIRLVTLCQPLLK
KEDALIRWGGEEFLLLARGREPLEQLAERLRLQIAEHPWEEIAPDLAVTISLGYHHCRAG
TPLQEAIHRADLALYQAKANGRNRSEGWQDDGAKNTG
>A0A8G1Q8I0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALGLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVTRRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>A0A8F9JZQ7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVPPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVGLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLSASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFEEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>A0A2T3QI80|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MDSKLRDYTTAPLFTHQKSSFLGADTRLLFLQQLQGKLDLYDVFQIFTQEIDKYIDVSKL
SWHFDNECALIKSTDMPKYHTYCFSLSFDERVLGELHYQTPYTLEPEEQTLLHHYHRLFA
GSLNNALEFRRIKKMALRDHLSDLGNRACFEQDIHHALAISERRAVGLTLVIFDLDNFKQ
VNDRYGHLNGDKVIRSFSKALKESVRASDRCYRLGGDEFIALLQPSTEQSAEKVTLRVIE
ALSIHPILQHFNIGTSFGYANYHDGDTSASLIERADRRLYYHKRNK
>A0A1V5WHB4|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MQLSADVLAQFNHLERSGALETLDDLRKENRSLERIITDATLLVSYTDVEAMLGFIISQL
LDYFIPRFLVFVIQPPRGKHIRQFCYRNLKKADDTLDEAYYEILRTHFKTNPASISLADL
QKALPPDTLGADFLQFEPEIIFPMFGIGGMYGTVILGSKIVDQKYTEQERKYVDRMIRFL
SVSMQNGLHYESSITDPKTGLYTHDYYMHRLEEALAHNRRHGTRSGILMLDVDHFKRFND
TWGHVTGDEVLLALSRVLVKTVRTEDCVARFGGEEFSILVTECTPEKLMQVAERIRTAIE
SLRIPCGDHQLSVTVSIGARMVDGLPGISPMILIGDADKALYRSKGSGRNRSTLYVQGLL
ERAFILRNSR
>E6BE90|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 85-1|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSEN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A1V5WID6|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
METQIQSIAHLVVSLYAGVLFFEGVRRRRDIDRFSYVSIVNAGLASWNFLLFLYYGLDNP
DTVYLVSQWGFVSVNSTIFGLFFFAWRISFGRKHDRLLPFFAVVPVVNCLLSITSKFQPL
FLSGHRGFQFFPLRELTIIKGPWFIVHAVYSYLLLTLSLTLLVILYFRAIKKNRAAKLLF
VVSAMTFSIFLFLTNFTSLKSAIQPYAFIGHLFCVSIFYWATFLDEDDSVVYFGIHRFYD
TVGMPVLIFNDGGELLHYNDDARRCFEQFNASLEKYNHFGRIFDGSFLSGGTPDSASGDD
RSFFAQNTQNAQTLYVGWRDIVNRRNVRIGYALILYDISRMGSFVKDLEKRAYTDELCQC
KNRNCFEQQRQRILEDSPRPLVLFIADIDNLKAVNDKWGHSAGDEYIRVCVTIMKKVTRS
TDYLYRIGGDEFAFFIPGLDETGIVRVQQSLESELAALHKEFPCSLSVGYSVFEADDYDF
EEHFNRADKVMYAQKKQKNRG
>A0A8E0J0H3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli HVH 70|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A157S5Z9|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
METEGSLVRVSLSLITPTILTLFGVAFVAVWAGYQRRIHLLCLAAACFAFGAGASSQILY
VPRDAGANALVSGAFYSSAVCLAVQGILLRARRRFSWIGCVAFVVLVMAGLWYFFYVQRN
LLARVYLLNASCGLLFCLAAVRLWSAPRVRMPDRLLFWIVLALGLHFLPRTVLTLGGSAP
VGARAFADSVFWQGLQLSLALFGIALALVLLFAVVSDVLQAAIDDRDRDLLTGAYTRRGF
DSRTRKRMAGATAPCALILADVDHFKRINDRHGHPTGDRVLAAVSETLSEHLRKQDILGR
LGGEEFAVFMPRAGLREAVACAERLRTQVSLSVPRVLGGEPVTISLGVVEISPGTSWEAV
YHQADQKLYEAKRMGRDRVCG
>A0A3Q9LGX4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 43:a:1,7|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1A6ARW1|diguanylate cyclase|EC 2.7.7.65|Clostridium ragsdalei P11|TrEMBL
MYKYKNYIFEVIILLIVIAVLYMTNLYSYLLFHSFAELFSVIIGFTLFIVAWNSKNFSKK
YFDYLVFIGIAYMFVSFLDLLHTLSYNGMNIFRGYNFYANQLWIGARYLESISLLIPFIF
IRFKRKLRPYLTFGIYTVVTLSIIASIFYFKVFPICFIQGKGQTSFKIISEYIICGILTT
DIILLRKNKNKFDSKVYGYLFGSIIFTIISEFEFTLYINNYAFSNLLGHYFKMISFYLIY
KAVIITCITQPYNTIFKELTDKENELEKTAATDEMTKLYNRRAGMEFLDKEMKNALRNKN
NLTICFIDVDNLKKTNDTYGHIEGDNLILNVVKLLVSNVRNSDYVCRIGGDEFLIVFPNI
AIKDAELIINRIRSDMDKLNAGSSFNYKVDFSYGFAEYNNVKKVDIDTLIETADSNMYKN
KVQKRKMTV
>A0A6N2S7V1|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium adolescentis|TrEMBL
MTVVTLFNIAMELWGVLICIVCAGGVYVGAIRRTRRTYTKVSMQLLCALMLLADVSAWYH
NGGRDKLDFYMTRIGNLGEYLINFIFIALFANYIWQTVSGDDMLENVSPHEWRARTSGGA
KRNRKNQRSANAQSKPKKPRSKKLDVIYAASALGIVLTIATQFNHMVYYIDSQNYYRRGP
LFAIPQILGLVELALIVMLIIENRKNLSRPLFVTSLSFFVLPIVTTIVQILHYGLALQAI
AITISIQFTFVVDTIEMNKKIRSQDDAYQKASYEAQHDGLTDLWSKSAGREQIENYFAHM
QEGDQAVLIFVDIDDFKQINDTYGHKVGDFWIREVAQTLKRLYRHDDIIVRFGGDEYVAL
IKNTANERVIESTLDLFRRQLAQASAQYGQDVHCSIGACRVLSGKNVDLNLCLGFADHAL
YQSKREGKGMYTVVDYDSGKVQAA
>A0A0D6E3X1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. R57-5|TrEMBL
MRYKDKHQLAAEWQTLLERTPRPLRQAVETLVTQHCGYFADHFYSVMLEDPHASLFLSNE
QVEQRLNPSMRRWLKAMFAVEHVDFEALVEQQEKVGQVHARIDIPVNLVLSGARQLKQAL
YRQLSASFKSPLSPGXASVYVSEHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQDIATLPKLANSDFGLWYFHKACHAFEGAPEIATIS
RHIQQVDREWLEVLLHEEASQRLKALGEIRDAARTVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDTVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDHDGSRLFAERLRQAVAKEPMLAGADTLLNVTISVGVT
LHDGHPDYNHSLQRADQALYQAKRGGRNRVVVHEGVESEHKLG
>A0A109Y4A2|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHQGMKGWLRGLLCVREQGDIAALMAIQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPSLLLVGPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAINDQHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGREAALAVAEKLGAEIRRHAF
SIPEAGGLRITTSIGVATFDGHPDYAYLIDRADKALYQAKQSGRDRSVAA
>S0G241|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MMTETKNHPPNSSSPFLQVLVVDDSAAMRMAIREELEPGGYEIIEAANGLDALVSACTDR
PPDLITLDVEMPGLNGWETCKKLRSPHYADRISRHRNSRIPVIFVTGQNTMSERKKGFSA
GAADFITKPFAEGELLETVDRILKPVALSQGMTALVVEDNVVARQIVADILIQEGLQVIE
AKDGQEGYALFSSHADDINVVITDLFMPNMNGDALSKKIRKELNRSDLPIICLTATPDQS
ELLNVFNAGVSDYLVKPFAKEELLARITVHLERYRLSRQLKEKINDLKISNEKIRKLSIT
DPLTGCYNRNYLSRQLAKEITRTQRYQTPISLVLTDIDFFKKVNDTFGHSAGDTVLVEFV
NTIHRVIRKDLDWVTRYGGEEFVIVLPETAYDQACQCTERLRKKIADTPVTHDEVPISIT
ASFGVTCLDPAQITDDFSTDRLIDTADHFLYQAKENGRNRVEGSPFKPA
>A0A0M7M562|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MYEDYRLHKERIYQATVSIARSMTVDWEREIHGVTAGLNVLAASEELARGDLRGFHAKAR
QIAQLQNVDSYVLVDARRMQILNTAHDYARPAVPASAPQGALDRVFSDRTLMQTDLFNTR
ATNRYLVAIGVPVIVNNEVRYSLQAGISPEAIGRLLRRQALGEGWVAALLDSQGIIAGRT
REESRFIGHPAVPSLRRAIENRAENTLESTTKEGAPVFTAFTHTSDGKWAVAVGAPANFL
LEELIASLAKVILAGIAFVGLGVALAVWMARAIERSIAALIEPAIELGRGGTFVAPPTHF
VETAALGSALTETSRMLARAQQLAYHDPLTGLCNRVLFGELASQTLAAAASARRQVAILA
IDLDHFKDVNDTQGHAMGDAVLEFVAQRMKTTFRASDIIARFGGDEFFVLMDDSNAETAL
SAANNLIRSLSRPYPGVEATVGASVGISIFPADGSDLASLLSEADAALYAAKDAGRGQAL
RRSAQD
>A0A6J4G1D4|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. SS-4|TrEMBL
MSGAFAARRIRVSIALIWVALTLLAVHVYIDLNRSYQDARERGVRLATSYARLVAEHAAG
TFDRADLVLERAVRLPQPEDLASARRLDDSRRAGIETGLKAIQAKAPAIVSMTMTDHDGY
AFANTVGTPPGGNLGDRGYFLALKAGGPEPAVSEVVKGRISNIWGIQVARSIPVPGGGFG
GMVVANVGMTSYMEGFYGGLSLPPGSIVSLRDLQHRLLVRHPVREDLFGKVIPSGEFAPL
FQAGGDEGIFDRVSPIDGVMRLVAVKKLAKYDIYAVVGIPETEVLGAWMQSRDQAIVILA
LALAVAVVATLLSHWKGKVDTTLRTQLSFQDALFDTLPIPIFTRDADGRFATCNKAYERY
FGTRREDLIGKTVYDVFPGELAANYDAADREVLDGSGNKTYEIAVVAADGSTRQVIIDKA
CYQGADGRPGGIVATVVDITERETMERELWRLATTDPLTGVGNRRHFLSIAEAELGKVHR
HGRPLSVVTFDIDWFKQINDRFGHGVGDDVIKAVAGVCTGVSRDIDVVGRMGGEEFAILL
PETDLAAAMEVARRLHERIGDIHIATDKGELSVTASFGVTQVRPDDGDIDIALRRADQAL
YEAKETGRDKVVFRD
>A0A377G0T3|diguanylate cyclase|EC 2.7.7.65|[Flavobacterium] thermophilum|TrEMBL
MALNFKETEKIYIIIISFLGLSSFWINLDFFAQSLWDWVLIYMLVGSIILLNFFPISLPP
KANSFSMDSSIYLAILFLYGISFTLKVLFIYSVVELFYRRKMSFWRHLFNFSMYCLMISG
AYYSFLFFHGEIGKINYYNLLPYLVSLLVYFGINVILILLFFLCVGQIFKGALELGILKE
ACVSYSITLLLSLVLAILLWEAKYFGLFLLIILVTLLSFIFKKFLQLYQLVSNRANKDHL
TGLYNHGFFKETLKEQFSDCKLLKQPLTLAFLDLDDFKKYNDRNGHLQGDRLLAFFGKLL
QKAVEGTNFTVARYGGEEFAILMPNTTKEDAYAFLNRLRKEVNDTYFDGVEHIPYRCLSF
SCGIAEMEKDMHESDELIHRADQALYYAKAQGKNNVQLYDKHNMCLDEIKFKQDLEALEQ
QVKFFLSKDVYTYRHSKRVFKYALEFGSRLDELTDHERQTLILGALIHDIGKIEVPRDIL
NKRGKLEKHEWEIIKKHVTWGREIVAAEKRFDDLLPLVELHHERYDGKGYPYGLKGEEIP
KLARILCIIDSFDAMTTERPYQPTKTFEEALEEIERCAGTQFDPVYAAKFVAFVREHYLP
LAEMEQLN
>A0A5C5VDV7|diguanylate cyclase|EC 2.7.7.65|Posidoniimonas corsicana|TrEMBL
MPTPRPEPDGGTPHSLPWEAWRHASDGVAIATPDGRSVLAHNPAFERLCQHLNLTPQQCL
DALAAELATLSPKGFCWRELHFPAAGLLRVGLMRQHGEPPTVLLMLPAPAHDPDIVTGLA
DRRRLEEELEARFHGGRPFALLFVDLDGFKLVNDELGHVAGDLALREIAQRMRESLRERD
IVGRYGGDEFVVLLDGAVQPEDLELIVQRIEDAAAQPLESVPGAGPLSASIGWAFSADGY
QRPADMLDTADRRMYANKRQEC
>A0A8F7N0S8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas amygdali|TrEMBL
MSDDAERWKEKYLKGIEQQDKLEKRWDARLDLLRRGLVRSSLAAEGSDRAVDECMKEMRE
IVRKDDMDAGLAALIPRLEKAVLDSEHRREVRVGQIGSALTALVSQLQALPLPREVRKPL
KRFAKDLEERASQARELPLLLSELSGLQGQALTLLEKHEEGPRQGLLQRLFGSRDEHGNE
HPPEAAHPENASSAQETHETHVEPEAENAHAPIDVAASEVEAAIVPDIANQKTKDAYTLP
PPVSEAETIVVTATETPVPSPAAAALAPALAETVTEPAVVPVEPIDYTDLLGPVPSVPYQ
QRPAPIIQALEEPQEDAESEAETVEGEEGYSLPSSPEPSYSSVAAHIEETLLGLLDDLTL
SEHFRPQVEDMQLRLKHGLNWYELLPILDDLAVLMLAINNGGQQEFSTYLKQLNERLESF
QSHLQAASEDHAEDQSTARDLNEQLREQVGGLQISVQDASDLTSLKQVLDNRFEGLLSTM
DHYQLKRDAREREVASRLQGLSARVASMEQEALGFRTHLEEQRQKALIDPLTGLPNRAAW
GERLEQEMSKWQHEKNSLLVCILDLDHFKRINDGYGHLAGDKVLKIVANVFRKRLRSDDF
LARFGGEEFVMLLPATPLSTGLTLLDELRAAVESCPFHFKGERVTITVSIGVTAFRTAER
SDTAIKRADQALYKAKENGRNRVEQG
>A0A1L8CM96|diguanylate cyclase|EC 2.7.7.65|Mariprofundus micogutta|TrEMBL
MGTLREDPHRAVILGAGIGGTAVLEMLLEEELVTVLAVVDRDPSAPGLKLAEQHQVAVYT
DVEQALKKCTPCVAFNMTGNEMVEAVVAEVLGSGGVIGGMEANLILSIINNLKKAKEDLK
FQASHDPLTGLRNRRYMMEQLQQGVSQALRYRHPFTVVMLDLDHFKKVNDLHGHVAGDKV
LSHMARVLRGGMRESDTPGRWGGEEFLVLLPHTDIEGAHQAAEQWLNHLTSAPLLLDNGA
SAAVSFSAGVASLDMVEKGVDLKVATDALLHLADARMYLAKEQGRNRVCAIGEPSESFNG
GQK
>A0A380NZD5|diguanylate cyclase|EC 2.7.7.65|Weissella viridescens|TrEMBL
MHTFAGFLIVVFFITSILVALVYVYQNMLIYSDQLFPKFIIVILYIVFTYIILILDANLV
DRLILYFVPLLFISLDTAPWKVIFCASIHPWLMALYIGRYAPIPHHDARILFISEIILMI
VLAVLTIGVKNKKYLAILLPIFFSGLEFWQSYQFKDILTPKSLSVFICILVAYLFLSWLI
CYINAVCTRLRNELFYDKSHDALTHVYNYQQLTTDLFQKAPIANRDAWIVIMDIDKFKSI
NDTYGHQHGNLALKLLLIPCKKP
>A0A446CK30|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MSSSSLGIPSSPDRSDDAPGLACYLSASNEQAWEAVYQSVDAYTRGQVAAVVADSVSQLV
DMFYSVLLADAEAGPRLSHEIVATRLHSGMTRWLKGLLCVRDQGDISALMSTQKKVGEVH
ARVHIPMHLVMAGARILKNEIAQRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQALPRLAASEFG
LWLQHKGGAMFESAPALQQITEAVARLDQDVLPRLMRDETPGQASSMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISIARRQRSEFSVVLLDIDHFK
AVNDEHGHAGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAGREAALAAAEKLG
AEIRRHLFTVAEAGPLHITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRCETA
>A0A602UA35|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVIQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1E3GVE2|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MPQQDVTTLQDRLNDLIRIAKSNERKQLNFQQYELSLLNSSGLEPLLKLILEEHKHRFQL
TAVTLMLHDPEYEFQRLLESFPETQQWQDHLLFTESVQRLEQFFSLRRTPRLVTFSQHQH
QQLFPSYNELGSIALLPLIRQNQLIGSLNLGSRNPNRFQSNIGTQFLEHLAAVVSACIEN
ARLHEEVKLVGLRDPLTGVNNRRFFDQRINEEFSRANRNRTPLSCLFVDLDYFKRINDSH
GHQTGDQVLKHVAQLLNDSLRQGDVLARYGGEEFVVLLADASRTVAADIAERMRKTVAET
DFTATKGKIIRVTLSVGVSTLEPGSNMTIKRLLQSADQAVYGAKLSGRNQVKVSAEA
>A0A1V5MBE7|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MADIKVLYVEDAKSSGGTLRQALKDAQVNLVLLGGGFDALDELIDSGADAIVSCLDLSDL
PGYQLSQLIKSSAGASKMPVVLFGTVSMGARIDPLWIKGSQCDLYVADRDIGNGTDVVKQ
LLELVEKSRSAGFNRSQASSMLKCRFNFSSSKVLESSQKLLDELLISRNATTLVSDMFKE
AGNRKALLDVFYRGAAAFIEADLVGLVVIGEAPWASFSADGVVSGSYKKLVDRLTNELEL
RSALEIDLRGELVEGTAKDLGSVQIVPVVAQSRAVGALVVASKDRNSFSDQAIAFGEQLG
MALGPLFELVLAKEAIANLESAAAYNASIDSLTGLYNLEFFVGFLQQQLLFSFRQRLPVA
VAIIDIDNFEKINEQYGVEFGDGALMTIASRLLNITRSSDLIARYGSDQFAVVLPNTDVA
GAKVLGEKVRSEVESIDFSGTSSISSGPVRITVSVGCASFNMEDLNPETILRDAKVALRK
AKDEGRNRVILG
>A0A823B0U2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIMEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLKILKSQIPVDKGK
VYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERLKMLA
DERLYKSKKNGRAQISWQ
>A0A380UYD4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIGSFAGAFTGYMIADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGALFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKNHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
INVALITSFTSAYIIYHVSGHYLLLYPQDYLGNTISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A2N9L811|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MNPGGNKRKPPLDPASVLGPTVGGHGPVAIVRDLARELLQQGRITLDEAGRIDGALRDHD
WPTVRTYVDLGLARRPVAKAAPDNGAATTPAPGAGPTASAPSREPPAEDQVLIAGLLRMV
MRLCDALPKLVLNDRSFVERFAPIRALLTARLTPERLGEAEARIAAVIDQQIEMQRDLED
ARSSLKDMLTMVVDRLGSIGNTTARFQQRISGYQEELGGQPDVLVVARVVGGLLADTKLV
SEEIEKSQQDLADARRKVESYELRVRSLEHELAQTARMVQNDPLTHALNRRGLEEVFRIE
VSRSSRYRVPLTVVMIDLDDFKSINDSLGHAAGDRALVHFVTTAQACLRSTELIARTGGE
EFVVVFPATGAADCVDAIRRLQRELERSGFQYEGQSRVMTFSGGAAAWREGESLAQILRR
ADTAMYEAKNGGKDRVVIAG
>A0A0A0MAY8|diguanylate cyclase|EC 2.7.7.65|Lysobacter defluvii IMMIB APB-9 = DSM 18482|TrEMBL
MEQSASRAEHDEPTGPSIADDPQLANAWRALLRSARPEIPPLFARVAERTLPDMADHFYG
GMMSDPRASRFLSVEKVRDRLKPSMQNWLREVLTATAGDVDSLVARQRVVGDVHARIGIP
VDLVSRGARELKNRLYHRIEELADDPGLALSASVLVSHSVDLALEIMTQAYVSARERSNA
IDASYRLFSLIQNISTERERQRALLLDWENALLYAIAGRTSTSADDCGLRRSEFGLWFTH
KALPSFGHTDETREIVSLMDGIDAKLREMLPACDAPAVRQELLGDVRTSVARIRSMMGLI
FENIGDLEAGRDALTSLLNRRFLPTVLRREIEHCRRSGNGFAVLLLDLDHFKPINDRHGH
EAGDRALHHLATVLTQATRGSDYLFRYGGEEFVAVLGSVNQQQALTIAENLRQRVATSPA
MLTDGTTLPLTVSIGVAMHDGHPDYERLLARADAAMYQAKKRGRDCVVLAVDDLPDPPGA
>A0A2N9MFN4|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MNLEGCGFSEDKLGTAVIPLRQSAIESALKNEAFDHLPSPSLCLNASAQVLATNRAFARF
VSIDLSDLVGRNISELIAVPRNAVFQRRWSRFWGRLLERRSCQQRTRIAIVGGRRVTLDI
SASLLRSEDDPIAVISLREIDADISARLSAARAAALGDGVAEGTMLLASDRRVLVTGGRM
RNLLGVNAAGAAGVPFEYLVDEPTARDFLQAFERLGGEPTRASVKLAGAARAFSGHTPPR
RLSLTLVNFLGYPRVNGVLVRVREFDERISLRDRADHLQERLSGYAEHVSDLTMLTDAIG
MVAYQSPAAHALLGRAPKDTIGKSAAALFIEEDRPGFSRALRAAVDANEGDRRRNYLARA
RGADGVLHTMWVSIRNCLDDPQLGGMVVTAADVSTLIAEAGPDARQARQLELRDRLLHLA
IQSRADFVQSLSGVLRSSADALRVSMAGFWRFDRTTETLVCESVYSRSEQRFLRDWIGVD
FPRTGVVESASRLRERTPLALTDTLVAGVERDPRWSGVRAFLSAPVLLEGEAIGVICVAD
SVSRRWEDDEIGFIATASLMVALAVEAAQRVEAEGRIEQLAWYDPLTGLPNRNLLRENLR
DALLSAIGRKRRLAVLLIDLDRFKDVNDTLGHLVGDSLIKSAAEVLREVVGTMGTVARLG
GDEFIVLVEEFTHRQEIAELAARMAQALHRSDFVPNVVTQVSASIGVALFPEHGREIGTL
LKNADAAMYQAKRDGRNQVSFFNPIRYERAAREVRLGIELMKAVQSETAQFFIEYQPQVE
IASGRVMGLEALIRWRHPVHGVLTPDRFIDVAEVSGLSERITRWVMQEVCAQILRWRQVR
PGFDIPISINVAGRELGSNVLPILVRAALSRFHIEPKMITLEITERTLVKDGEINNDVVN
ELSSLGVGLVLDDFGTGYSTLGYLRRMPIRAIKIDRTFINGIPQDPDNCAIVTAMLTVAH
HFKLAVVAEGVEHSAQASYLSSLGCEYAQGHFYSRALAPSIIVEHLAVDKTAKT
>A0A8E2P476|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNSYWRLTESSDVLRFSTTETTEPERMLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A1V5M583|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MIDVDHFKQINDSHGHLAGDRVLAALGQLLKKRFRVEDIRGRWGGEEFIVAFRHIPRNTA
RGALQRALEELSKLEFKGDRDESFSISFSSGIVEYPAESKDLSDLLRRSDEKLYRAKEAG
RNCIIA
>A0A332LLB6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEMENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTAMMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALSVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A8B3Q9U4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKRYFLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLNQRHQEIWRVALPNRRTL
PVFGVSESVVREHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTHYSRAISALWFTRQTQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMKGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMALASACQR
SGLPLAVIQLDLDHFKSINDRYGHQAGDRVLSMVASTLAGTVREGDLLGRVGGEEFCVVL
PNTTLQEAAAIAERLRLRIHGREVFLHNNVTLRVSASLGVSASEEQGEYHFEALQSVADG
RLYLAKQNGRNQVCYRSEA
>A0A3D1C510|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFALVDVNSFYASCETVFRPDLKGRPVVVLSNNDGCVIARSAEAKEIGITMGEPFFKQRD
LFRRYNVATFSSNYELYADMSNRVMTTLEIMSPRVEIYSIDEAFCDLTGVRNCRNLEDFG
KEIRATVLQNTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNVDRQRRLMSIVP
VEDVWGVGRRISKKLNAMGISNACQLADTSTWVIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTEYDQMHQAICSHAARAAEKLRGEHQYCRYISAFVKTSPFAIN
EPYYGNSVSVKLLTPTQDTRDIINAAVRCLDNIWRDGHRYQKAGVMLGDFFSQGVAQLNL
FDDAAPRRNSEKLMTVLDQLNAKEGKGTLFFAGQGIQQQWQMKRDMLSPRYTTRFSDLLR
VR
>A0A7Z7X3D0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
AEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A5E4TJE8|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MKSTISRTEQGNRVAATVILVACAALTLAGFLARAIQGNVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTRAPFWLWLMAEA
SFAAYVMLSVRSYSRTRNDPHIRPGYKEAARYGATVLVIWATTSLALVGTGRTLVTPPLP
GGVGVETLALYALFVAYVALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPNDAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRLVADRVQQRAVPLSVLLIDIDFFKQVNDRYGHPFGDVVLQRIANTIQHCIRLPADFAV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKAREKGEAITISVGIATWEP
GKPLVINAMLERADKALYQAKHKGRDQSVLGQLAA
>A0A377W9V2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MYNRRGLQNRLDTLLALDGDNHYVLLLDIDHFKAYNDHYGHMMGDQALIRVSAAIRNAVR
SRDIVARFGGEEFMVLLTNSSEETAWKTAERIRQRVYDLKIPHMFNESVATNVTISIG
>A0A2X3FX62|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MIFTAIQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQA
VSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNGGRNRVTRMPFDSSERRRSR
DGAA
>A0A1V6E5P7|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin110|TrEMBL
MSMRESCVIVDENGRIVDMNQKAKEMLPFLNSGVIGEKALDVFSIFPSLIEAMIHPKEQE
MELNASSVGGPEWILAKISPLNDDRKDSIVYAIFFEDTTERHRMLESLQYYATRDDLTGL
FNRRYFYEAIKPGIEASINKVSEVSIIMIDIDSFKEVNDAYGHALGDKVLRSCAKVLAAN
IESESDAIIGRFGGDEFIVFMPEASLEEAQRIAEKLRLSVVAMPILEEIERPLHISVGVA
AGQIERFEEIEMLISKADDAMYKAKRSGGNRVCT
>A0A2X3EHP9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSVCSPICWVTFGVLELYYSCQILFLPGCRKPSAAEQSLETLVRQLLEMLEAVTRMESTY
LTRIDTNAQRQQIMFAHNSSEMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIA
AQELGIATFLSIPVRLADGSLFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLV
QQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAIN
DRFGHPCGDSFLVQVGKRLTAVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQAL
CGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A483IRU2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGYRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A0N1QXB1|diguanylate cyclase|EC 2.7.7.65|Salmonella schwarzengrund (strain CVM19633)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQERKKK
>A0A8G1LVI7|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MSEQQKILVVDDSASNRQLLGELLQADYTVLLAKNGEQALLRAREQLPDLILLDVMMPEM
DGYEVLQLLKADPDTAPIGVIFITGLDTPDDEERGLLMGASDYIAKPFHPAVVKARVSVH
MQVARQRRMLETLANIDALTELPNRRQLDAVLAAECSRAGRTGNPLSVAILDVDYFKLYN
DYYGHAMGDRVLQTIASVLNGKMKRPSDLAARYGGEEFVLIMPDTLLEGALEVANKLCSA
IAALQIPHEKSRDYACVTVSIGVASGTVNVPPTAESLLQVADARLYRAKAAGRNRALAT
>W6KB35|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MIRKKIPIGWLLGLISIGGMLVIGGVLGLVTLKSFGGAFEQHAARLTLSQTETSIAGIHE
FVRTRTDMLRDIAHSPLLLQGVMQQETGLPNAVDHLESSRLAGQRVRLMLFDFEAMPIHD
TAAAPRQPPKEILTALLESDSPTLARFSWFPGGKSALWLGASISWRGSTEGVLIAEIPMD
RMGFLSARMFSTGHGKLEILQDSKTLFSDSWQAMGKTIGRGLPQLGVQIRYTSDLSQIRR
EQQELAVNLIFVGSLLVAAIGLITFWVGRRTLVQPLLKIEQMTARIINGESVESASLKSH
VVELQSLGRRFDEMARETQLARQHLQSLVEARTQALNKELQDKKTATMELRKVSALQSAI
LESATYAIVTMDPLGTIMSFNPTAERMFGYRAPDMIGKRSVLVLHRHEDLVKKSETLSRE
RGQTIASPFDALTFVADRGRVDETECHLVRRGGGTFPARLTITRLGDRDDLVEGYMAVSS
DITQRKETEEKLQLAHEIIQKAGEAVVITNPSGQIIDINPAYEKVTGYHRKDILGRNPSM
AKSGRHDAAFYADMWTTLNATGRWEGEIWDRRASGEIFPKWLGINAIRDDDGHVSNYVGI
FTDISAQKSTERKLERLAFFDPLTKLPNRALFRDRLTQGLEMARRDTHPLALMFIDLDRF
KNINDNLGHDVGDEVLIAVAQRIKGCLRKSDTVARLGGDEFTVILRDPGDSVDLGTLADD
IIGVLTKPFHIREQDLFIGASIGIALFPEDGADDETLMKNADVAMYQAKQAGRGTYRFFT
NEMNDNTGRRIALEADLRTAIDQDQLALHYQPKIALENNRIIGFEALVRWNHPTKGMISP
IEFIPLAEETGLIVPLGEWVLKTACTRIKNWRTKLNEDLTIAVNLSARQFEDPLLTEKIE
GILTELHLPSSALELEITESIAMADVERTIAVIDGLKSRGLRISIDDFGTGYSSLSYLKR
FPLHSLKIDKSFIHGLAIASDDEAIVTAILSMAHSMNLNVIAEGVETEDQLSFLRTNDCE
EVQGYFISKPIPAEDVEKML
>K0MGJ8|diguanylate cyclase|EC 2.7.7.65|Bordetella parapertussis (strain Bpp5)|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDLDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLINGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGAQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>W6K5V0|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MPGMPTDPLASPIETKPLLRSADLRAMLDGQSDPALLLDTKGAVLATNPPGQRIVNALES
GHPTDFKPQIVAAMQGNGPLTGSYTFDGDDEAALILEVQILPLAPPHFLLLGRDVTLERN
LRAALVDSRERFKDLVEASSDFAWEVGPEGRFVYVSPRGALGFEAARLVGHAPSELLKKG
GDSRNPFVTRAEVEEAEVWVRRADGTRACLIVTAVPLQAGDGAWRGARGVCRDVTSEREK
DAALARAHQREKILNSVVGAIRDEVDPQDMLDVAALATAQAISADGVRIYRGDERDGFYL
VAEQGTPSSNEALDELVRNVHADHRVLDNNAHGLSMLAAATPYRHQVNGAICVWRDEKGN
AWSDDDRIIAGDVANRLGIALEQFSNHERILKLSRTDGLTGLLNRRAFFEDELPHRLRKS
GKPGGGGALVYVDLDNFKLVNDVHGHQAGDDALLKVCEILDTHTRASDLLARLGGDEFVL
WLDRMPPDVVRQRVDELHHSALDLKPLSGDMARPLGFSVGVAIYDPAVEEGMESLVARAD
AAMYTVKNRGKGGIEISLPGGGEGEAS
>D7Y8B8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain MS 115-1)|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A0T7CRJ6|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVTRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A5B7XH20|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNKEFTLAPRLTFKRTLRRISIISVLITMTLVWLLLCIASVISLKQYAQRNLELTSATVS
RSLEATLVFNDTTAANEALATLGKQGQFSSAVLLDRYDHPFATWSMGPNDRADPLSKLVS
RWLFPQPIRQRVWHNNLPIGELHLTARDSLISHFLWTSLAVLTGCILFAAMVALIITRTL
HNGVVTALQNITEVVHDVRSNRNFSRRVSEERIDEFHRFGQDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRTSITALMNDSLARTNSALLFLDGDDFKLINDTWGHAA
GDCVLIEVARRMVEFSGERHQPYRLGGDEFAIILYGIHSEHEVLRLCAALTQQFSPSYDL
QNGLSTRMSLSIGFALSWEHHSVETLLDQADRNMYLVKHQRSKNTA
>A0A6B8N8Q6|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MLDKQREAWLSLILNELPDRLFVLEQSGRFVEGFGGTFHSVRLEKNGYANKTLHDILPQD
KADQLLSYIQDVSESAKPLVVQYSVNPIECLQLSIDELETLDGPEDMWFEATIKPLCLVD
GTQYVLWQERDITSNYRRQEELKRLSETDELTGIFNRRAFLEALEQELQSYNETQRNLSC
LMIDIDHFKEINDQVGHLSGDEVITQVARICQKQIRGSDYIGRLGGEEFGIVLSNTNAIQ
AYDIAERIRQSIESSPCSVDDHIIHPTVSIGIAEVTSGISHVKELLVQADKAMYYSKQTG
RNQVTLYHDNLPDMKVQSAIQAKIRQAS
>A0A6B8NGB4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MVDTQQCLTNPDAQLIDLSKWQEMVNLLADLFGAATGAIVQLRNDEFNVVVSSQNPDHYL
EAQMNWPWNMKSFCRHMVETRQDLYVPSAATHEVWSAAPPVAEGAVRSYCGIPIFWPNGK
PFGSICVIDTNATSYDKTLIRMLCQLARLVTLDLDTACRLQEAEELALKDDLTNTFNRRG
LTLLGEQKIKDAPRYQQAIGMLYIDIDNLKQVNDKGGHESGDQCILILAQTLREACRQSD
VIARLGGDEFVVLSLLNTRRELKQLAARVSAEYLAQTKDKESLSLTSLSIGSHIEDCFGA
PCLEDLIAQSDKAMYQNKQSKK
>A0A7I7A7U7|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MDKPLWVRKLRRVSGPGHVVNYCFVAVLFFSTLLIWREVAVLEEAYVTNQRNNLENVAHE
MDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHDPIWSVALHNRRTLPV
YGVSDAFVDSQSMLSRHDARTGNELMAALELGYLLRLVDENRGFNEGMLYISRSGFFTGT
TLPKNAVQAQARYTHAIAAPWFTRQSQRNNPGRGVLWQTVFDGHEQNDDPVVTASVPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRFNLIASSASGNVLTLLSAREQ
AMLSYAFSHQNQGSIRLLTRYISWQKLNNFDGVLLRTHTLQEGVRGAFGSITIALTLMWL
FFTLMLIISWQVILRMVRNMSVMQKSLEWQAWHDALTRLLNRGALFDRAIAITRVCERTA
RPVSVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCIVMPD
TTLQMATAIAERIRIRIYNREILLCNDTSLRISASLGVSSSDDSAGFNFESLQSTADRRL
YLAKQNGRNRVCFNDLFLRDGMGK
>A0A564UFD1|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MEEKNCEILFEYLRDIIYDSENAKLDLEQLDEPFLKLGMGLQYLDKAVKEMKHYSAELSQ
GNLSIEAPGRDNFLCENLKNIHANLNHLTWQAKQVAKGDYSQSVSYLGEFSEAFNTMTKQ
LKEREEELEEEAYRDKLTGIGNRHLFHERAETMLATGEKIVFCYCDLDHLKYVNDHFGHQ
EGDRYLLYFVEKVKANIRPGDLFVRLGGDEFCVVLLNCSQETMQEKFRNVHEAFSRDGSG
DYPKSFSYGIIELPGGHDIVSTDEILQRADEVMYEYKRKHKEKYLKQLEK
>A0A7I7AE82|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MSDESKKYISVIFKEWLPLYDGLTPEVKAILKNIAAEQSEALATRFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKDQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDYQNGLATIRYAVMAITMAIEMMCHAYTLSHYRATKNEEAYRLYSLM
DNVPMEYGKQQASLSGWENSAIYNIVSENRADINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLIAQVDNYITGWKSSDSGAEYKNTQALLQSIHIHCQKISSQLGVIFSSLSQMQN
GKDSLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDSWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSTGYAVHTGHPDYNRLLRNADSALYVAKRSGRDCVKMHQDEQGPQH
>A0A1V5GQK9|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MSKSIRKRIGLTISCVLALFVIISFIVSFICVLSVGSEYQQSIADSALDFSELTINADTA
KEVFATRNINDEFVSVNNKLYTYQNRSKNVIERISVVVFSNSAGSYIYDTGGQTLGSRVD
YDNYTESIKAELINGRNEIQRIESKQLTIYRPIRTVDDRLAGHIIVKLNQPFEYRFLPVL
IAVFAGLVLLSVIIVFIIVIYLNKKIFRPIKQITDSTVYLSGDDSASEGKDTSVIFDTDR
SDEIGQLSKALQKILFDMNSGAEHLSQALYDANHDGMTQMLNKRCYHSMIEKFTKSESIC
IIYFDVNNLKLMNDTHGHESGDYVIKRAADYIREFIDKNDYCFRTGGDEFVLIMLDCSFR
DIDHIVTHLDRDCPYLLNRESDTVKCALSYGFAYAKGEYVYDDLVAEAEANMYEKKTELK
KQLNMPDR
>A0A1C3JPZ2|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MPEYKKQPWHLIWKRWFSVTLNAGAINHSFTNSSRRTFIINLFCLVGVLFTAPLGILSLL
QGNLLVGIALLVIATIYILNHLYLRRTRNYLFSANVILYPLYTLMLYLVYSGGVNGTGHV
WIYCIPPVSLFLHGLKRGLLEVFVFILALIFILFVIPTPFDKLGYHPDLKTRIIYSFILI
AFLSTIYEYISSRFNQSLQELSVKLEVAATTDPLTELLNRRGLQQSFEALQWHAPALLLL
DIDHFKRINDDYGHKYGDEYLVLFAQTLEAFFPKQESLVSRWGGEEFLVVIEKVDSLRDM
AEALREALKAITLSTGYDVNMSATVSIGVTHVGVGEDILKAISRADQGLYAAKNRGRNRV
EVVEKSSGN
>A0A8E5MVU1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Dessau|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A564W9I4|diguanylate cyclase|EC 2.7.7.65|Candidatus Defluviicoccus seviourii|TrEMBL
MSLKSRIAATIFLVEAILIAVLLLATAAETRESLARHFRATEQTLLQLMGDLSRAAFLTE
DYAELQAFIDQAVEHPRIETVVLTDVRGRVVVSTLPNLLGTTLREFTDTEHHHWRLREVR
GHSNALGTIAVRFSDAAVVEMYTRIRNGALLIAVIGLVVSSLVGVGVGFLLTRRLERLAS
AADRVADGDTSIRVDDRGGDEIGRLTRAFSSMVGRLQRRAAYMKRTRDLLIEPTQAMSQG
FAVWDADERLVLYNPRFRQLFHEIADDVVSGLPFREFCSLLDPHIRGEAVSEWLCNWDRT
GHHAQGVWELRFRDGRWLEIRETRTTAGRTIGIVTDVTSARAQALALVESERRLRAIMDS
MFDAMIIVDDNGLIDTLNPAAEAMFGVRTRAVRSRPIGTLLALASDDDRSGTAPPCQAAD
LKVIQGRPVREMWGRPRRGATFPVEISVSHALLKNGRITIVTARNISERKAAEQQIVYHA
THDQLTGLLNRSQFMERLRATIEGSTDAQDQLAVLFLDLDRFKVINDSLGHMMGDALLVA
VAKRLRRSLREHDIVARMGGDEFTVALPGIDSEATALRICRKLIETMRAPFVVKGQELHL
TTSVGISLYPAHGDSPEMLLRRADTALYRAKAKGKNQYCLFTAGLGGNVDYHVYLENELR
QAIELGLLRVVYQPQVELGSGKIIGAEALLRWQHPRLGAVPPKVFIATAEDAGLIGKIGT
FVLAQACAQLRRWRESGAGPLRIAVNLSPRQIHDPEWPATVTSCLESAGVPSDCLEFELT
ENVFIEDDDTTARFVEAMRELSIGLVLDDFGTGFSSLSYLRRYPIRRIKIDRSFVSDIGG
GNDGALVRATVAMASCLGIGVIAEGIETRPQWEWLRQHGCPEGQGYLFGMPEEGERLAQR
ISGIKRHAGQVVAFSASREAFRERAHPVGRDT
>A0A808FKU9|diguanylate cyclase|EC 2.7.7.65|Xanthomonas citri pv. phaseoli var. fuscans|TrEMBL
MGFEHRQWRSSHRRAPLAMVLLLALLSLADLAGAQSASIRRYAHDQGLLGLAGTCLLQTR
ATLLWVCTESGLYRYNGRIFQQVPLDGLRNEPTTSIAETADGRLWVAGFQALFVGDEHGF
RKLQPDEAEHLGEQMQLATLSWGTVLANGGTLEILQGRANDRWHSEPLLDTATRVRVPEL
AKSLSLSVDGDTLWVGCARKLCAIDAQRKVQVFGPEHGVPDDRWYSVLRDHDGGLWVRGA
GTLLYRARGTTAFSVRSLPLLDGSTVGRPASLVMDREGRVLVRRNDGLARWENGHWRTFG
ADNGLPPGSSDAILVDRDGDVWMTVDGEGLVRWAGYEWIENWDASQGMPAAPTWSIARDA
QGALLVGNEHGIGRQADPGERFVPALHSAGIQVVGMQRSADGTLWTLNSAGFLRRTWPDG
HSAQIAKLPRTARRLLIDRQGRLWMLSAGGLFVIEHPLDGGSLQEVADVPAIAYTDIQQT
ADGTLWVSSSNGLFRLRDGRWSKVKVKVNGGTPEPWIAKFHISDSGEVWLAFYRPGLWHG
MLLHDGLDLQEISDEALRDVGVYLLRGDSVGRVWVGHARGVEVYDGERWAHLSQSQGLIW
DDVSEAAFAEDPDGSVWIGTARGVSHVSDPARLFDERQPSVRIDSVSRGGMPVQRGQLLG
WSDKPLHIELSTMEVYDDPSRLTVRYRLLGLHDQWIQSDNLSIDQPPLPSGHFRLQVQVL
DRYRRTASPIADLPFAVAPLWWRSPPAIALYVLIGGGLLIGLWRWRHRHLVARERMLAEL
VSERTYQLEREKRELENARAALALKASRDALTGLLNRSGILEAMAEELQGCAHGEHPLAV
VLIDLDHFKQVNDEHGHLVGDAVLAKVGARLTACLRDSDKVGRYGGEELLLLLPGMSQQS
QHRLRAIHEALSLAPYEVGAARPLQVTCSVGVSWFRVGDTAASLLARADEALYRAKRSGR
NRIEPEEPESSVA
>A0A655PNR7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MRFHTFAEETLKGSQSLIALQWLVKVEPPQAETFTARMQQRFPEFTLYTVPKTGEIKHGF
GTDDQAKYVLSDIYPLNYDNRKLLGFYSERERFKRILADIVVNRRPNVSDKVRLLQDGID
KSIVKDGMLVYHPVFSSEDDRSLLGVMVGVVRLSTYFEKLVQISVMEQDLDMRVIDTGFD
SEDSPVLYQSPMWRADDEPKIERKLVLPNRDWVLEFELHQPINHSEEWVLLGLGLGGVII
SLLLSYIMRMQLEEKQRLTDMIEERTAELRYLVEHDSLTNIYNRRFFSQHLCKMLDEKQS
FTLISFDIDRFKQINDSYGHLAGDYALTHVVDVVKKELVESDIFARFGGDEFAILSSVTD
ETALYTYLERIRKVVEAEPVMLNAETPLTLTISIGASINCEYSEPEILQSVDDQLYLSKS
KGRNRVSIAQQCSKVESNYAFNSGRMFDFM
>A0A3S2Z9N9|diguanylate cyclase|EC 2.7.7.65|Hwanghaeella grinnelliae|TrEMBL
MTKTRVISGKRACPMTPSDETGRGAKNRAAAKGSETGAERRGPDRPPACKPQDVLGALDE
GVDELRRFMQAWHRSIVCGKPPDRRVMALDSHMQTQFGKWMSERSGDGLLQQPAFEELTR
SHRQIHEQARRLANVVLEGQPIRTAEYDGLINHVSRFYDQSRRLRDAFAKLVSEIDPLTG
LHNRQIMAHDLDVEFERGQRTGGPLCLALTDIDHFKRVNDTYGHAAGDVVLASVAGRFQS
NLRPYDSIYRYGGEEFLITLPNANTGTAISVLERLRGALETAPIALSDGTRLPVTASFGI
VRVKYDIPLKQSIERADKALYAAKQGGRNRVVTWSEALETETLEDQAEEEE
>A0A7Z1CYV3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDEVWGIGRRISKKLDAMGIKTVLDLAGTDIRFIRKHFNVVLERTVRELHGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPPPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A7L6JMB0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00524|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A7Z8FEA9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAKELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPGD
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A7Z8BHR6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKIYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNARSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A8B3KEZ7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A0M2WFP4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MRVPDLSSLRRVAVPLAFGGNSEQQHTYFAELHRVGMVTQVLGIIAFSLTWLLMPPTYHP
NLTHAVLALLGMLISLVVRYRCTTLPVLTITGACAVLALTFGLRTMADAVQHASFWVLPV
GVFMTLAIASIFNGGLSYLAVVAGVWWNVGHGLYPVNAGLPDQSWAPLMIAVSVLFGLAL
NVSFSLLRLRNYHSKVELTRLAFQDSLTGLNNRRMFTQRAQQMYGATHGGMLHFLMIDID
NFKIINDQQGHDAGDAVLVRTAAVIADKAQGHLCGRLGGEEFGIVYAGDREDARAFAGAL
VEAVSDAFLAAQFVSISVGVAELDRGKDLGHSYRLADEALYLAKRQGKNRYVIV
>A0A736H3L1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIDHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6A5KWB6|diguanylate cyclase|EC 2.7.7.65|Lupinus albus|TrEMBL
MLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDKKRTLPINGVSDAFVDKT
TLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRAGFFLSTDTPDRAGDITA
RYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITASVPIYFDHYWYGVVAMD
FTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVNQFDERETAQIAQAIEHD
TGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISIVLALLWALFTAMLLISW
LVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLAETCRQQSLPFSVIQIDL
DYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEEFCVVLPGLGLEEARGVA
ERIRCRINTAVRGGRPAVSGQAERA
>A0A5P9J1V3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MTPTVKAQSHASARLPHLNTFPKLLIGGLLYYALAQFGMTFMATQPANITLIWLSVGVAL
VMYLRLGKASAIVVFIASFAANYPGMQVADMAHGVVHTSIAALIDTLAPWVMAGLVKRHL
QSGLSRFQDLVTLVVRVYLLPIALSVVMLTVNLILGGYIGSELFAQYVLQLLFSDILGAL
LVYAFFDAFVKQQQWPLRQSALACAAIVLALAAMLTGKLWLGGFIFAVLPCVLVMIFVCA
SVFVYSVLLAVVAALVVLFGHDFGPFIQDTPMQSLFMLQSFIVTLSMLTIGGRLLQSQLL
NETDSKHYWQHQARFDDLTQLMQRNAFMDAAEHSLRCGGLKGKSSSIAVVDLDLFKKVND
RFGHQAGDEVLECVAYCLTKQLREHDLAARFGGEEFVLLLSAHLEQGCGIVERIRIAISE
LTFDDYPELRVTCSIGVTHVNQGEDIGSALSRADGSLYKAKQQGRNQVCINH
>A0A5A9GU54|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYRDGRGGERSSAPASFEAWCQAARRDDL
LQQPAVQKLANLHEQMHRQARLILLKASGGELPTETEYEGVIGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETGLDEGYAVIERLRVDLMRSPVMLPDG
RVVPVTASFGLVEAVADLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEQKPVTVKAG
RG
>B6JFU3|diguanylate cyclase|EC 2.7.7.65|Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)|TrEMBL
MSARVLVVDDVPANVKLLEARLSAEYFDVVTASCGREALDICRRAECDIVLLDVMMPDID
GFEVCRQLKSDPRTHFIPVVMVTALDSPADRVRGLDAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRALTSCEIGVQAPEREVIADEGKGGRILLVEDRPSSYERLAPILAEEHT
VDVEPDPAQALFHAADGNYDLLIVSLNLENYDGLRLCSQARSLERTRNVPLLALSNADNN
VQLLRGLEIGVNDYLLRPVDKNELLARARTQIRRRRYTHYLRDSVQSTFEMAITDPLTGL
HNRRYLEGHLATLAEQAAVRGKPLALMILDIDYFKSINDTHGHDAGDDVLREFASRIRKS
VRGIDLAARYGGEEFVIVMPETDQHVAGIIAERLRRAIANEAFPIEKGAKQIEVTISVGL
ATLETKHEPVGDVLKRADQALYRAKHDGRNRVVSAAA
>A0A734HME6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:l,z13,z28:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A653KQM6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MLQESDTIRISDLSEAVVHGILEVVSDGIWDWNVNTGFVYRNPGWYQMLGYEPHSLGNNV
FTWESVIHPDDIARVMACFDAYLTGSAPDYRVEYRCHCQDGSYIWIEDCGHIIARNPDGS
VARMIGAHRNIHARKLLYEQLESRNHSLEQLVAERTAELVQLNGSLQQKAEENRQLAETD
ALTGAASRYRLERDIQMECERAKRFHQPFSVIAIDVDDFKQINDSHGHAAGDQTLINVVA
RVQSHIREIDLLARWGGDEFMVVLPNTALADARRVADKLRALIAQSQVCEQRDITLSFGL
AEYRLNEPLSQLMVRVDRALYQAKLAGKNQIGE
>A0A024HLE7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13)|TrEMBL
MDQLLSFLSTTVPQAKSLEQLTRPLLALLGQVTGMESTYLTTIDLEQGVQRVEFARNDGD
MEIPEGLQVPWEDTLCKRALDEGRAYTDDVSGCWGDSDAARALGIRTYVSAPIRAQDGRV
LGTVCAASAMKVARNEQIEPMLSLLSGLLGYSLEREVLVDRLQVLNSELAQLALTDALTG
LYNRRAILGEIPRLLAMARRERRFILVAVIDLDGFKQINDNHGHQSGDQFLSQIAERLKD
CLRGSDVLGRTGGDEFVVCALGNLAGQGTLAEDMELAARLLQGRLAKATVGRYALASGTD
IQYGGASVGVVALLADGIDADEAIKLADREMYRVKQQRKRGASVA
>A0A6N2SBT5|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAILLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARLPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A379CM66|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MKRKKRSFLLSAFAIVLLANTIYFLIGHTLLNDNDSLKIKIDSLLQKTIPALNLSGSLMM
STDELRYALLDLRLQGKPAAQIRNSKEQQAVSTAITDYYPLIESTEEHQIYRRLQDNWLL
YLDGLNEQVQSETDFLRSIDYLRKIDNLSYALVQKNNDYIGEIRSHENQSHLKAAQLFGY
GFIFNLIFQAIAVTLLYRLYISKNDAILSAEVDPLTGLYNRRKIARTWDKINIHNSAIVV
LTDIDFFKKINDTYGHDGGDFILREVALLFQQIIGEQGVIARVGGEEFAFLFKKHTVDQA
FALAEQIRESAEQRQFDYNGTPIQLTLSFGIARATSKHDSFEKVYSAADRLLYQAKHSGR
NRVCR
>A0A6N2UKL4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MKIVQDSLRNRQALIISALTTLLFTSLFLFIIYEQRLAAVNEGMNRLQTRMLDIFNDNEM
IADATGVRYRQIKAADQCGAMSLFLPRGRVWGINADRKRIHSASGAMVAREPTLNALCMY
TAAEFIRGRVNALNPGNFDAHRYVIAEDASYFYWFTPTDTKAFNYRTSQMAQNISDFFLP
PVDFYTRLLEKSVKTKALSSTDFYNDKITDEKAFSVVSYIYDLSRTEISDHILGYLVYDH
AKPELQEALRDAFDGQVPHGLNVSLVNTLNQQSLCLWGECKKRPEIAFKVLSEKYVIHYA
ISLSGFAMHDTQAGLLILMAPFFFVLIMMGLKSWLNESDLKVYIDSLTGCFNRKILDIIK
RRDLSDSSVVLVDCNKFKAINDTWGHVAGDRALQIIANRMLSNTRTSDDLVIRTGGDEFV
IVLYKAKTSDAVAIAERITQQINEYQFLVKETQVPLSISWGVAEVTESIDDAIQYADGEM
YKMKQAK
>A0A658YVS8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDALRFSTTKTTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSEHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRTQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
SLSPEHGSDSATIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIENHLAWRSAQSGSTSTLAVT
>A0A380AWQ8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAV
EGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRK
DIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDR
PLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWK
SVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGS
SVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNKQNKNSRS
>A0A384KWB2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A0H2V0V8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINLLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A8H8ZBM1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A379ZQV5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLSGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMLMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7Z1EMN2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3S4DUD3|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MSDFILARVSQTLATERTLETLVRQLLEMLELVTRMESTYLTRIDLEAQRQLVMYAHNSS
EMQIPEGFSVPWDESLCKRAIDDNCIFCNEVGQRWRSCTAAQELGIATFFSIPVHLADGS
LYGTLCATSRVKQPYNLEGEQVMTLFAGLISHYVEKETLVQQLRSANAALEMHSNTDELT
GLANRRALFRHLKTLFTQARAQQCRLLLIFIDLDDFKAINDKLGHPCGDSFLIQIGERLS
ANVRNEDTVGRLGGDEFLIIGPALESPEQEAFIAHLRQQLTGRYRLAGYGIEYPGASFGV
INVDPQNMDVEQALRAADEAMYHDKNARRMLTIFDIDQKA
>A0A381C2Q3|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MTATTWRALLKGKHQLSLRLFLLLNAFSAGFSIVSPSANTQHFTAPIIMVLVISMSCLLW
QFINKKKLININVVSLIIGLLWAWHIYIKVSAMPVVDLNFLIIALLAILFIGSISFINNI
QAFFASCLPATAVILWLDHGANWPRVLYSVVLPGVGITIQHIIQKRNDNFTRRLMDKLLE
EKETLNDLSMLDPLTGLYNRRGFRNRLDTILALGSGQHFVLLLDIDHFKAYNDNYGHSMG
DQALTHVSAAIRDAVRSRDVVTRYGGEEFMILLTDIDAERAIQTAERIRQRVYDLKIPHL
FNDDVATHVTASIGIAALEQSDIEEALRQADTALYRAKRQGRNSILISDSLLPA
>A0A3S4DPA8|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNKDFSQAPRPTFKNALRRISMISVVISMTLVWLLLSAASVITLKQYAQKNLELTAATMG
RSLEAALVFGDATAAEDTLATLGRQGQFSEATLLDSHQRHFADWRNDALVKNEKIQWLY
>A0A7C6T6N8|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium|TrEMBL
MTQISTEQLIKEWQILLDSTPSSIFANTQQLAEQYTAELANSFYKHMLEDPVAAQFLSDE
QVKERLSGSMQCWIITLFSLTARDDLQPVIAQQKHIGDVHARINIPVHLVLRGARVLKET
AAQLLSGHAQHKECLSFITALIDMAMEVMSQAYAVSNDKNSRAEESYRLFSIAQNSAHEK
DRQRAALFDWENQVMFDIAMGLQFSQLNALSASEFGLWFRHKGSHAFEGASETDLISTAI
DKIDTVILPMLKLAQENPEQHQQLLRNLHEQMRSIAYHLENLFSQVSELESGRDVLTHLL
NRKFLPVVMSKEINYARQHKRNFCILAIDVDHFKKINDSYGHEAGDTTLQQLASLLSNGC
RSGDYVFRMGGEEFLMLLVDITAEKAVKVAEKLRLLVEKEEFRLPRGVSLKITISIGLAQ
YAGHPDPQMLLNRADDVLYQAKNQGRNRVVVAD
>A0A447LEZ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MARHNRKLSFTTPIVVGFAGILLSFLLIAIFVTATQKKNFLEDYHHINRNFTHNLAVNYT
ESLLRENDYILARATKYFARDDALNSAVNLNPQKGLDDLMRLQELMPTVSSISLADTLGH
YLRAPEVMEGDESRTFDPKTRPWFIRQAEASTFSLYTSPYLDYFTHHPTVTVYRPVISPQ
GRLKGSLAFHMDLTSMGYALRQIVSPVQGEFFVVQRDGKVVIHPDTGALFKTYVSAELMD
KMTSAEGQLYDEEHKAWYYYYSFTNPDWFVIFRVTDTTLADLTRYETDIVAWGFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGIQI
LQPQEISLYRYGGEEFAVIFPAEHIDNALTILESWRLNVASRTWREEGLTVTFSAGLGEW
NMEPLEKLVVSVDEALYKAKQQGKNRIVRA
>A0A7W8NCX3|diguanylate cyclase|EC 2.7.7.65|Rhodanobacter sp. ANJX3|TrEMBL
MKWHSGGDFFTSLYPTLAMRTAMMKTARSKPQTFDFVGKLAVSMARAHTLEELVRPLLEM
LEAVTGLESTYLTTIDEAAGVQHVLFARNTQRLRIPEGISVPWESTLCKRALEEECSYTD
DVALRWGDHDAARELGISTYASTAVRTHDGALYGTLCAASDRRKPIAEGAEQVLQMFSIL
IAQQIEREKLVLALLKANEILTINSLTDAITQLPNRRALMSEMGKRIASTALSDQALIVA
FIDLDRFKAVNDQYGHDTGDRLLVAIGARIQGAVRSSDFVARLGGDEFVVLATVARSAAK
AMAKRLGAKLQAVGTGQFHWDDQVVDCAGLSAGLIIAAPDARDAAALLAQADAAMYVAKR
ARRDTGILH
>A0A2Z5SEX8|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MPRKKKTVEDPALTRALKVMEAGALPDADLAAEFAILTESYGKLLRKFNKTLVISDAYEA
QHQAMAKKLEEATWKYRQLKDVALPICMYCKKIRSDDDYWQRLETFFCNHADIMFSHGIC
PDCIKTAYEKMGMNRRAMPLPDAAVAGQPAASPERQPVEDDVLREMRALVRRSAFDGSPV
APEVEQFVEKYGKLLRRFNKIVSISDSYQSQLRELNARLELMARTDLLTGLANHWEMVMR
LAAEQSRSERNGKVFSIVLADIDHFKKVNDTHGHQAGDRVIRGIADTLRTNIRREDICSR
WGGEEFLIILPEADLPRAGAVAAKLLAKVRNTVVPWDGRDIRVTVSIGYGTSEPGMSVDE
LIRRVDDALYSAKAAGRDRFAAAGSRADV
>A0A7W8CNQ1|diguanylate cyclase|EC 2.7.7.65|Planococcus koreensis|TrEMBL
MTALLFFFLENMALIIALMYLGLKTKETLFLDWTNPVRQRWAISIFIGFLTFSIMYNPFM
YEGMRLDLREVPLFFISYVGGWQAGLLSAVLPAFYRGLMGGPTVVIGIIQSILLPVLIGG
LFHDRKPANQFFVILNIKRMMGAFVVFEAIKSIWMYLATPANTIVTLGMVFFAAIAVLAM
GLILNGENRNLVLRKELEFYSNQDPMTHLPNIRYFKNHVGKLVDNGTPMAIVMLDVDYFK
VYNDTHGHQKGDAVLRSIAQILKDSTRKDDFVARYGGEEFIVCLNNPINTQEAALLAERI
RQNVEAYQFEGEAKQPEGTLTVSMGMSCPMDLKSLEDMIEEADQALYQSKRQGRNRVTVF
NASA
>A0A6N3GWK7|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MSQNGFDALNAIKTPVWLISPVSEQIIFANVAATQLMGNKTLDGLRKGTCSASAQSVLSM
YVPELKNDHDIVEIWTISRAGQDTPLSCRLSLSHFTPYGDVIVFEGISSQTPSGLKASRS
TTYQRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALSFYGYSHDEMCNKHTWEIN
TLGRGVMPIMTEIAALPGGHKPFNFVHRLADGTTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLELELENAALRDSMTGLLNRRQFYNIIDQTNLSHLSAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSRQDDLVFRWGGEEFVILLPRTSLDTAMKIAESVRAAVT
RITIPGLPRFTVSIGVARHEPEESIDELFKRVDDALYRAKNDGRNKVLAA
>A0A379AB32|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MSEEALRLQIQNLKKHNARLKRIAHDARTKLNAALDGTGLFLWQLDIPSGKLVIFNRRWG
AMLGFQPKETDANFESWKESLHPDDAADVLQAFNDHIAGKAPYYEALHRMIAKNGSITWV
LDRGRVSEWNAYGEPVKVIGTHIDMTKEKQYEEQLALLALHDPLTLLNNRHALQNYFCEM
KAQGPLCVVFIDLDNFKHVNDTLGHRSGDEVLIQLSQRFTELSPAEVIIGRLGGDEFVLL
IPLALNHPRVKTLAHACLDAVMTPFDMANGHALIGASVGVSQAQDKDDFDTALQRADEAM
YRIKKNGKRGVAFDSTFPDSL
>A0A011PRZ0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MVGVVLDVTAQRRDEARLRQSEEELRAAFEQAAVGISLVAPDGGWLNVNDRLCEIVGYRK
EELLRLRFQDITHADDLASDVAEIDRMLAREIASYSKEKRYIRKDGGSVWVNITVALIWN
EDRTPKHFVVIIEDIDARKSAERELGHTREMLRNFLDHLPGLAYIKDQSLRMLHVNRRCR
DLLHRDAEQLIGKTSAEIFPGDRGEGVSARDRQVLDSGNSEVVERSYGDSRYQSIRFVIR
QNDDPPLLGGITIDVTQRYKLEQRTTALLEINARGGTLPEKEFLACALELAEKLTTSRIG
FLHFVNDDQETIELSTWTAGALQSCSAMFDAHYPISQAGIWADCCRESRAVCFNDYAAHP
ARRGLPDGHAPLQRLISVPVLDEGAVRMIIGVGNKTGPYDDFDVTSVQLIGNDVWNVVRR
GRAEADLARRLAEVTELKDQLEQAHLQLLQSEKMSAIGQLAAGVAHELNNPIGFVYSNLG
TLAEYVDDLLAIDAAVDRVAQLPAQAGCRRKPAAACSTRFAGSRPRATIRTSSRTCRS
>A0A0E1NGN1|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MVATDLDALNILSTPIWVVLPKNQEILFANKEARKIAGDIQLPRMRNGRFSAHAQQHLHA
YLPALAVDDHVIEIWTIQTEENAFPLSCRLSLTQLEPYGVVIIFEGLYISESVVTQPPSS
KLMAKAYSRSEQSFYEQFFSTNTAPMLLIDPSKEGLIVDANQAATRFYGYSRDEMCRKHT
WEINSMGKDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGMRLMLCII
HDITEQKRLEQALEYAALKDPLTDLGNRRQFFPLVEHAHAQSQRYGQNFSLILLDVDHFK
NINDQLGHHKGDEVLIFLARTLESIIRECDIVFRWGGEEFTILLPSTNLKGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A1V5S4A5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin300|TrEMBL
MSLKTFSQAELYYGFNKDTFFSQRSNIGESNLRVLKNLSVTVYFTEAAEVLFLRFFSPES
LIRIVACLLTAALSLLVFFLCRKTLLSKKSLKSRSVNVLIFFTSLFYCLNAGFFGTFFSA
DRPGVKFIILLCVLQIIFIVPPFQSLLTFAFIPFFFIYFSIYLNEGNFSAINLFYTFVSI
SIGLVMSWSISKIKIENMISAEKLRKSNYDLYNENVTDSLTGLANRKMTLNTLYELFNNR
NADAAYLNCICMEIDYFREYNRFYGTKSGDKVLILMCDALSNYCKKNGITVGRVGGGEFL
ILFNDSSPDKGEKAAKELQSLVRELNIPNEASPISSEVSVSLGLFTDKTDGYKFFEEIYT
LSGRALYRAKENGGNKVWKYIPEINGFSPAEQ
>A0A1C3JHK4|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MSDKAFRQLNIFFSVFCLAMTVLSLISFHTIMDKNYIITPDRNPTRVNTDRDHDGGTIGS
LLRSKDKVELQCDFNRTYSSPFCEVEFVLSTEGKGLDLSTFDSVTINMEYEGQEDPRFRF
YIRNHNENYSVQGDPISNKFNRLDFSLPDRKHIDLAYFNVPLWWIDYYNHPITNSGVDIT
NAVSVELGLGASTLDGPHTLTDESIVFHGKIMDKVMLWKILISLWVIYAVCYVCGASYVA
RRARILSVNQQRLLLAQEIEELKIKATTDPLTGCRNRTEALDTFYDFERLAKQGKTIHIA
LFDLDHFKQVNDQYGHETGDQVLILFVSTVIDNLGEQYLLYRWGGEEFLLVCIEQTTLQC
NATIAKLYSSMGETTWPKGLNITASVGFTQLTQNESIRSAIKRADKALYQAKDNGRNQVV
TFD
>A0A736VKS6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 45:g,z51:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A753EJI9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 45:g,z51:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A518B809|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan216|TrEMBL
MVLASPKDEHEFPPADPRVHSAPQTMLAVVVGAILVVGVGYLDHKTDERLAFEIFYLPVV
LWASWYGGFIAGLVAAVSSAGTWALNNWFDRPAPLSELLLFWNVSVRLIYFAIFAFMTAR
LRGAMELNRALSRTDSLTGLANHKSFVEQTNRELVLSRRHKRPMTLAYIDCDHFKVVNDT
MGHAAGDTVLQTIGKTMLATVRESDVPARLGGDEFAVLLPETNAANARSVVERLREQLLE
MMKDNDWPITFSIGVVTFPTPPESCTAMTRTADKVMYTVKHGSKDDVAYAVAE
>A0A8F9CBG7|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MNVSTASLSDLVVERVGFGIFVLDRQMNVLMWNRFMHDHSGLSAEQVVGKSIFASFPELP
RVWLTRKLESVFQLGSFAFSSWEQRPYLFKFDHDRPITGGVDFMQQDCTFMPLMRDREVE
AVCVTVSDVTHVSIMQREREEAVAKLQEYADRDGLTGIANRRYFEVRLRDEYTRWQRYGG
DLSILLFDLDHFKKINDQFGHVAGDSVLREMAQRVAGVVRAQDTFGRFGGEEFALLLPCT
PLEDAMLVAEKIRHTIGDTPVDVHGVSVPVTASVGGASARAGVPAYEALINEADAALYTA
KRQGRNRSIAFI
>A0A518AZ96|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan216|TrEMBL
MSRQLSSSPPATEQTVRSRFEALDAIVASGLTMSGLARVLGQWIVEGFPIRECTIRLTDT
RGFDRYYRADASSQDVSEVLVTAASPRDSRDANTDARNVSIEGSHDLLGDVEVVPISPDA
LTPDLQEQLVHLVRRFGFLINCHVTMERARAEADRDELTGLYNRRFLRRCLRQALAEPSP
RPMSLLMLDVDHFKKFNDSWGHAVGDRVLRLIGELMQSIFRSEDIVCRYGGEEFAVLLCD
DRAKPTGDHPHEVRQYAERLRREAEHLRLTSEDGRVLSQITISGGIASVPWDARDADELL
LKADDALYIAKRSGRNQIVFSDGLAKSA
>A0A753EE54|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 45:g,z51:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
STLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A087AQQ6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. gallinarum|TrEMBL
MARLLIIEDEAELLHALEQLFVHDGHDVLTAIDGEQGLRRFREGRVDLVVVDILLPKLDG
FAVCKAIRRGSDVPIIVTTALDDEGHQLQGFSLLADDYVTKPYSLSVMRERVRAVLRRCA
TRSDAAASHAIEPTTAGGPAGGAPIAASAAECGPGTAARGLLGFGDIIVDTEAHEVLLRG
DVVALTRTEFDIIRLLAEHPRRVFTRDALARQVWGYADDCGNKAINIHVMNLRRKLGADS
VDTVRGVGYRAGTRHG
>A0A5B9WDI1|diguanylate cyclase|EC 2.7.7.65|Aquisphaera giovannonii|TrEMBL
MLWSQTFAGLVAGPLSIREAEDVFHELCAAIDGMDDAGAIEQTLLGAAGWITRGGEARWV
DEEGGRGAAVDGGPAGARRASCWEFPARRGDGRRRLLVVPGPDTPPSAYQRLRTLCVVAD
AALARSRAGCACRFTGPDAEGAGAGLGPIGLTPDCGESWQEEPASECPLQVQDGTFLKAV
LPFAVSQARRHQEPLCLVCLAIDRLAGLRELLGEGTVERLAGRVGAKIVGIVRASDVVCR
MEDNRFLIILPRACLPSGLAVARKICRAVEDAPELFPELGGLTVSAGVAEFPASAPSVYS
LIDEADAAMERAQARGRNTAVAADGAYCPGALAC
>A0A4V1CTZ0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A564FYU8|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MRLDVTTLLIVTFALTFLVGLLFLLSWRQSRDMPALLVWGIAHLAGSVASVGLALRGQVP
DAVSIGLANTVMIAAYGLIWSGIRMFEGRPFRPVATFTGAALWAVLCLVPAFYDSIVARI
IVASAIAVAYTGHGAVMFWRGGHEPLASRRPAALLLAAYAACYVVRIPTTLLMPPTEVRN
PLASSWVTVLCLASMLFTLVVAFLFTALAKERAEHRQRVAASTDPLTGVANRRAFFDRAE
TLAASGRPLTLVLFDLDHFKAINDRFGHAIGDTVLVGFCEVACTLLPPGSLFGRLGGEEF
GCLLVAREPDAVVAQVECVRQAFSAIRVADLPDLRLGASAGVACGTGARFDVLMRRADAA
LYAAKRGGRDRVAVAEPVLKAA
>A0A4P7TR11|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A653WDT3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 8BK|TrEMBL
MKLSLGNKLTVLLCLFGLLLSGLASYYSLSSSKQILVAAAKRDLLVANQVLGRNLQISLE
NFANDLKVLSTQSQPVDVLEDTPRSNREAVELTQLFTSMLNAHPEYQRIRLIEAKNHGLE
RINVDPQGPISSNALQEKGHFPYVFKTLQLVPGQQFFSEIAPSRLDPDKALTLHLASPIW
KNDQQVLGLIVLSIDVKKLFSRLQREIPDYYQLFLANSQGELLLNPERNTSQGRDQGPSV
MIQSQLPELLALLEGQSTNMLSILPAKREQPTRLAAFTSVSIEAESNHLLLGLAVPEEHI
LQASRELDQRLVQIIVALSLITLLLSLWLARKMIRPLNQIGLAIAHFSKNLSLQPLPIER
GDELGKLARDIRAMQEKILAQIIELNTNQQELQHMAHNDPLTGLPNRRLFFDRLQHAISN
AKRNGKLLGLLYIDLDHFKEINDSHGHAAGDKVLGNVAHLLGSVTRSGDTVARLGGDEFV
ILFDEVENRATLLGIAQKLLALLQNRLLIDGKDLQVRASLGISLYPQDGSDAQTLLQNAD
RAMYSSKCSGRNTITCA
>A0A0J6VLN8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MFDGLRSSSARSIGPALWGSDQYYWFTAVLAARGMQTATCRLVAVCIAALGLIPVGLLAS
PVGPRGTFGRTAAVVIAVACFGLATVWLRDHWPTRAQSLLCVLIGSISIGVSALIQANPV
VGLTGAASYAVLTAFVVCFHTARLLALVWTVAVFALGVLIVRLAATDLALAICAAGMIIL
LNVFVAFACRAMILLIQPDTHHGDIEQLTGLLHRDAFYQSVATLLASRSRSADKYLVVVA
VNIDSFSLLLGLSGPSGGNRARVTVGQALRETVRHNAIVAHVSDDDFLIADSFTTADASP
LVERIRGAIAATPQRLTASIGVVCTPLPPLAAEPPDEVLDKLIAIATQAIEQARMAGGNQ
VRYVLRPTLDEDPDGDGDDPRPGTGKSA
>A0A238DML1|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MDDPATLPLLPAASRADARAAAMRKPSAPTLARLGWRLMASAAGLFATLVGLWLWSSWET
TRHDLEQRSELTATLLAVNAETTFLRIQDDLQQLGDTLQNRGALHDPVGMFIALDAFKSR
HPELGGATVFSPDGQMLASTASRPTRSLPNVLQEPAYADYRDDFNLALATQGLSVGRPQY
GLLLKQWFIPLRYAVRGADGQARFVVQTSMLLEHQQALWRGLPTQPGVAMGLLRTDGWLI
SRYPDQPSHVSIYGQPAKGALVRALRSAGDAWRGIYTGKTADGEQREGAWARLRDFPIVA
FLSYTHDEVMQMWWADVRAPLLALGGMLALLITAYTLLLRNFVRRMVRIRRQMDFVRAEE
LPSSGVAEIDALLRQLVRSREHMRRFARNREKALLEAAQAGTYTRSLRDGVLVAADSSFA
RMLQRPVRRLIGREWDELFNTVDEVPVGEAIGDAKTQKRGGRRLVWTRGLHGETIWLSLA
EHAETTAQGHKVIHGLAIDVSERENLLRAVERQSQRLQTLWELATGSSMEDPGVETGDAI
AYMLAQGRDALDMQAAIICLRLGDECHMLYVQDLHGRFRQGQTLSANHPLCACDDHENGA
LWIADTSLHPNLAATAGVRSVIRLPLVRAHQTLGCLLLLGDDPQGEEFDPTDRQYAELLA
AWFARVLHDRNQRDTLLAQAYTDGLTGLLNRRAAQLRLDEALQSMRRGGQSFSLALCDLD
HFKLVNDEYGHAAGDAVLRQMASTLRQGVPRGGWVARWGGEEFLIMLPGLDTQAASAAMD
VLRQRVAQRPFLVSERSLHITLSIGIGGLQGPQDEVVRVLTEADDSLYEAKRQGRNRVIT
MR
>A0A8G1HY62|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. ERGC3:05|TrEMBL
MSAAGGKGLPLASRLYKSRALGLTLGFVCVVFGMYPLHPPAWVWVWMVINAFVWPHLAYQ
WSRRVSNSLRSERRNLLFDSFCGGFWVGAMHFNPLPSVTTVSMMTMNNVAIGGFRFMLAG
WVAQGLGIGLSLLMFGPAFIAVTTEIQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDQLEIEFQRCRREQVGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRTSDLAGRYGGDEFCVILPDMPLNRATEVMDALRDRFSALAYAQDPT
LRASLSIGLAPYQAAHADSTSWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A080MAT7|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MSSSPPLLPPVDLRADDVEIGNYATLLDSLDIALLVFSADGSLQLRNTQAATLLGDTPVV
WEDENGQPLAVDQRPEREVVQTRQVIRHRAIGIRKAASGATDWYRASAFPVFADDGSLRR
VLLALANLTRDRQLASQSMPTHDPLTGVFNQGYIRLLLDDEDRRARRYGTPFSLALITID
DFADFCAANGREAGDRLLAEVGSLLGRNLREFDMVGRFASDQFLLILPNVRINDAMIGLE
RVLAAVEATYAHHTRAPLTISGGVTEYSGEDSSILIEHLKPLLSAAQEAGGNRLCVDLEI
F
>A0A380AD03|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MELRGLLRLLPLLICTPLLAHADRLAMANAKLASQDVSVSITQIVRYCVDPDWLPYEGIR
EGKHLGISSDYIDYIESHSSLKFQLVSTSSWTETLSFLQSGQCDLTPMLNKTLIRETYLH
FSDVYFRSPNVLVSLKDQPFLQGFENIGARTLAVPKGYRLAEYIQHYYPQIETLTVASEP
AGLQSVLDKRADLFVGSMFSVNSYIQQTGFNHLKIAGWGGPEDELRMGVAYGQESLLPVI
NKALNAVSEQERILIYQKWNNVTVIDETNYSLVYQVICATCLLLLMLGARTYFISQYNRR
LTDKNQQLETLRKQLEASNAELEFLSTHDPLTKLYNRHYFNRLFINNEQHDKSAKAGMCL
VMIDIDYFKEINDTLGHNVGDRILEQVSQVLQHCVRESDVVARWGGEEFVILCQHSSLPL
VESLCVRIAERIKHYQFTDNVQLTCSFGVAKLADNEPMMLCFERADRALYRAKAQGRNQM
CTDK
>A0A080MDS9|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MTNERIRHIEEWANPRMVVGVTLLLVGALWLALMVSVVADRHESIATTGGLLQRMTHAVE
EQTRQQFRVADTFLASCEHWLQANPDLDPRTDRTFRQLIETFRAGTDQSIDIYLLAADGQ
MFDILDPAQGPLANVADRDYFKGALNSPGLFVGNPTRKPLADHDGLPLSLSLQHPANDIQ
VLLAVIDLPTLTRSYEKQRLQPGGAITLLRRDGTVLARAPHDDRLPGHSMASEALFREHL
AQQPQALVLPDARLGTRAREFISYSSMPDFPLVIMVSEDYDEALAAWLRQTAWVILLGLG
VTLPLAFIAYRSLHLLQALTSQDAELQRLATTDLLTGSSSRQHFFETLTDEVARARRRQI
PLTVVLFDIDFFQRINDGYGHAVGDQALILFANTAKEGLRDMDLLGRLGGGEFALLLPNT
KAREAVLVAERIRKAIPGISIPSDNGTVQFTVSVGVSEVHADDTSIDDLLKRAATALHNA
KAGGYDRVAVV
>A0A1J5RF33|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAELVQPAEIAREVLRRLAMQRTPPTPENYLRLYHEIAGTTAAEIFPEKSLKILAAALPR
ATPEQTRFARNLDAAVSEKSWEALKAALLALTAAAGAEPPQWSALIHELVLQLERTHVGL
TPAKKREVLDHVLKSSNAPELLFSRLQSLLRSWSQGPTAEAEESLVEGEAGVRVEARAGA
AETPLASEWRELLAQVLENSLSQLLSDNPALIEEAAKLAAAVRAARNSDDIARLGGQMKK
FSYRLNFVAEDQAELRTALLHVLHLLIENIGELAIDDQYLHGQIAVLLELTGQPLNLRRL
DDVERRLKDVIYKQGALKKQLHDAQDRMKAMLASFVDRLAEFSDTTSGYHDKIERCAEQI
SRASDISQLSDVLAVVMQETRAIQLNAQRSRDELCEMRRRVEETEKEVGRLQHELAETSE
MVRMDPLTGALNRKGMDDALEREVARAMRHQAMLCLGLLDVDNFKKLNDTYGHHAGDEAL
KHLAAVIRETLRPQDTLARYGGEEFLILLPDTTLDAAVQTLTRLQRELTRKYFLHENQKM
LITFSAGAAELGPQEAAADAVKRADAAMYLAKRAGKNRVVAA
>A0A1J5U5G2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNKHLTPAGIALLYGILAALWIFLSDKLLTLFLPEHALALWINLFTSLVFIAATALLLFL
LMRKLLRQATDKDRQLKLFYDLPFIGMAISSPDSKAWLYANERLCDMLGYTRAELQQTTW
ADITHPDDLDDNIAQFERMKSGEIDGYSLEKRFIRKDGSSINANINVKCTRGVDGKANYI
VALVDDITQRKRAELALRKSEATYRSLFDNMLNGVAHYRMIFRDGVPVDYEFIAVNPAFA
LTTGLKDVIGRKVSEVIPGYAEANPDSLQVFGKVARTGEPTRWEHYLAALDKWFSFSIYS
PAPGEFVVVNEDISERKRAEAALRESEDRFRNIFSNAVDGILLADATTKKFVMSNPAIQH
MLGYSAEELLQLGVDDIHPEHDLPDVLTKFEQQVNGKITLAPNLPVTRKDGSILYADINA
APIMIGGKSYLMGFFRDITERKQTEDALHQAATVFQYSHNGIIITDLEGNILAANQSFMK
HTGYSEAELLGKNPRILHSGRQGKPFA
>A0A1J5SUS8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSNPRTDSGLPSVLKKLGAMTAIRDTYLVEQSLLRTLGPLLGVLETSFYRLDDNGGIARA
LYHSRKVEQKEGVKRIIDNIEEVAVGQEVTDTERNLFESVRLLGKSCSRKVGSDLHICYP
IYGNSELVGYFLFQRDREVTPVEDAIVHGVLEVFTNYFDLLDTSQRDQLTGLLNRYSLEI
NLDRLWNLLSARLHESIEENTKRINTPDTYWLGVLDIDHFKNINDTYGHVIGDEILIMVT
RLLQSSLRQSDLLYRYGGEEFIAIIAANDLDSAIQAFERARVKIEQFQFPQVGHITISGG
FSNADPGVLPQEVINRADSSLYAAKDAGRNRIFHYGTLVKQGVLKETPSGSIDLF
>A0A1J5SVA1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MGTQAQMPSGLIAQPPWQALTKTLDRLHPVVMICAASEILWINRAGAACLGHADPAGLCG
RSFFEFLHKDYAELADFGLAVFAEEEGAISIKLVHADQHDIDAQMWVSPLEDGLYMVECH
DMSEHLRAARALRQREQRLEGIINTVADGIITLDERGVIQTFNPAAEHIFGFSKEEVLGK
TLRALMPDSLVDDGRPAKDWVQLLSQMAHLTGKKKGGEEFPMEMSVRELQQGEYLSFTGI
VRDISARRAEEERIFYMAHHDALTGLPNRHLLDDRIEEAFKRSRRHHYKMALLFVDLDKF
KPINDRFGHAVGDDVLKEVARRMGQVVRATDTVARVGGDEFMVLLEELTTVAEAEDVAGK
IKAAVSAPMALFGHEMAVGASIGIGVYPDHAKDMCELMNFADQAMYRTKNQTRV
>A0A1J5QM35|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTSNLNKNIHNQKDTCVATTSLTEAHQRMQISEALVEQAADAMFVFSRDDGRFIKVNQQA
CNSLGYTRDELLQLSVGDITPGHDLARRRLAWDSFEVGKQYSFIATHRRKDGTIFPVDIH
LTKLQISNEPLMMAQVRDITERKRMEHDLRLAHAAIQDSRNAFFWISPQGQVVYANDHAC
RNLGYTRAELIGLYVWDFNPDHSSEAQVQGWADIKQNGMMILETRHRRKDGTIFPVEVIK
EVLNKHQFRTLRF
>A0A378RD21|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MGSGEQWLNWLAGGNVAGFLCRRDGADVVIVDRTPMFEAMTDPGAGWPGEVALLAGLAAA
WPAADGSPSVLHVDDAPDWTCVLQPLDREPGRCVGIVRGTSERQRYNDGFHSIVEALPDI
VARLDRNHRHLYINPAIEQMTGLSPQAFIGKSKREIGLPPELVAQWESLVDRVLDSRAPA
EEVHELPTVGGSRQFLTRVVPEFRSDGELLTVLSTSHDITELTSLQRQLAVLASTDPLTS
LLNRRGFSERLESELSRARLGGDHGGRHVNLLMLDVNNFKAINDKHGHMAGDRVLVAIAE
VLRHAAGADDFAARIGGDEFCVGLVDSDGDSVRAVAERIRRRIGDLGADDGCPCAVSVSV
GLTADIEAGRSVSDLMAAADQSMYAEKSARRDQR
>W6RG97|diguanylate cyclase|EC 2.7.7.65|Rhizobium favelukesii|TrEMBL
MAVREDLHRDGSGPRFGGQRLLLVEDSRMFSAVLCHRLHAELGLNVKPCSSLKMLEETIA
QSPTDYSMAIVDLNLPDAPYGEALDCTIKAAVPTIVFTATFDLDTRNRIMERNVIDYVLK
DNEFALDNVVASVRRVLSNRKTRVLVVDDVASARQVLVGLLEAQQYMVVEAASGLEAFAA
LEAYDDIEVVVTDHQMPDISGYELTRRIRRRFGSDRLRIIGVSSSSDRMLSASFLKAGAS
DFLYRPFVAEELQCRIANNVETLIQLKQLRAAAACDYLTGLYNRRYFYDLGPKLVNDCLR
HKAASAVAILDIDHFKRLNDTYGHEIGDEVLKAVAGRLAAIFEGSDRLLSRLGGEEFAIL
FPMMDSIAATKLCDEIRSDISRLKVMADDEELSVTVSIGVAEISDHETFDNYLNAADQFL
YMAKHKGRNQVYSDARMTEEAAQ
>A0A1J5P4Y0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MHQMAAKLLQTASSGGIISPLDYDSFINALERLRLQILTLKRELEETLYNLDPLTGAHNR
IGMLTKLREQLDMVKRHVQSSCIAMMDIDLFKTVNDTYGHSVGDIVLAASARNVMEHLRP
YDKLFRYGGEEFLLCMQNTDIGLGYEVVERIRQGLAANHIDYGGKKPLQITMSFGIALLD
PEATVEQSIERADKAMYVAKIAGRNCTRIWDETM
>A0A0M6Y2R7|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MDLSTLFSANVLLLSIFAICFLAISLQTSPRAHWLSWAAANTLLASSLVCFALSSMVPPL
VAYLLPNTLLLLGFGCHWHAARLLADMPSKLSNVVAPAFAYGIVAGCAYLLSNYALAYMA
SNVVFTLLSVATITVYASRPFRGLISNIGLILAFFFLAAEGVLRTVHGLVSGGPQGPGMI
DDLIVDIHLMCALVFVSLTGAFSLALSFELVANRNREAARRDPLTGAFNRREFQTRLESL
LQETQKDDFGLVHFDLDHFKQVNDRFGHVAGDEALVKVCSEVKAHLRQNDCFARLGGEEF
AVLLPSISRENAFRVADRLRERISDLRFEFAPQDFNLTASAGVYHGDGSQLPSAELLKTV
DESLYLSKRTGRNRVSVVEKVSGAIPAEPLRAAQE
>A0A1C6BQ31|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKLKWRGLQFEHYILGILLAVEWIMSFTFLGYIHIPPISITTAHIPIVVIACLFGPVESS
VAGLFFGLGSMYKASALYVMLGDRIFSPFQTDFPIGSILLSVGTRVLFGFLMGCIFKIVN
KSRYKWAGKSLAALIATPLHALLVYGAMGILFPESGFNYKSSFRWGVNNYAIAAICILAV
ILSDIIYHSSFVTHYKNVINDSELRQHWSVKMKISLFIIIIFVFCIAAFSTIYFASRTEY
MFGVYGIKVTKKIAQDILHLQVQFLAAMISLNFILIVIILMIYNYMKHREYMGEMDALTN
VMGRRLFLNYCTKCQNDRDDIDNKSKRKGWFLFIDIDWFKQINDTLGHTVGDETLKQIAE
SLKNIFSSYGAVGRVGGDEFAVIINEKMTKEQLEEQLKKFLLDISTILPERTVSCSIGVY
HFGFPKSQKELLTRTDDALYKAKEKGRACYVILDE
>A0A1C6EW87|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MGNMKKKRIEQNEIKRYFLIIAAFLSFMILSLLFFLSWLQQDVEVSSRKTVATNVERQSY
HLKSVLDIQFNYLTGMASYMGEREDLFCQENKRLIQSIVKEQDLNLIGIMKADGHTYYNN
GARKNVKNRGYFKKVMQGQKIMSPPLESKVDGRTKVILAVPIYRNGKVTGALGASYNVGA
LNQMLFNDIYDGIGFSMIIDTSGKIISFDSGLSYRKIGINDNVYDFYTKSGEVAEETMKS
AKVNIKKQKSGILVLKEKNAMSYLAYEPLHINNWMLCYMVPQSKAQEEFQFIGNKEVILF
AVIGVGVITFFILIFQRTSMKQKKMREIASRDGLTQLYNKAGTEQRIKEWLHSDRSKSGA
VLMMMDVDYFKQINDTYGHAVGDRVLYKIGHLLKSSFRENDIVGRIGGDEFLIFMEGITS
EEFAVRRMENLQQYLRELPIEELEEHTLTCSMGAAFMPKDGTTFGELYKHADEALYTTKR
NGRDGFRIYHEVEEKKV
>A0A379Y1A1|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MVGMIACLVLSTLCALVLSRRMLVGIVSSLDDIANVAHAVRRDRTFGLRVPSAPIAELHE
LSNDFNGLLDELEAWQAHLKQENDSLAHRATHDSLTGLPNRAFFEGRLSRALGDIESPAK
LAVLFIDGDRFKEVNDSYGHAAGDAVLTTIAGRIRAQLRETDLVARLGGDEFAVLLAPVH
GTEDVLQIADNIIDCMTQPVILPNDEAVITSLSIGIALYPDHASTPQGLLHEADDAMYQA
KHRYNGGWRLAIHK
>A0A1C6FZ98|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNQIVSLFMFSCGDYEKVKQDTWEENWKAMRLYSVVALVAFGVITLVSVFSLSIGKFKWV
YLVYTFLSLVCFCISRCQLRSFLGKELVVYSFFAALLLFGIITGTLITLEELTVNYIVFM
MVAPLLFTARTAVMNGLILSSMLLYIGLAFFAQHNPILSKNLVDVILYGVLSMLLTATMM
RSKLQRILYHKEKEMLEVSKRESQERILNYERFLTDMVRYAASEETPDKVLNQLVEYIGQ
RMTANRAYIFEQNDRGTFDNTYEWCKAGVSKEKDNLQDVPYEGIIETWFAQYQESNNVII
HDIEECKKTSEAIYEQLKPQGVNTLVTGPIKINGKMVGFYGVDNPPEEKLHEISNLIDMI
EFMISFMIRLRNNADALEHSALYDQLTDCKNRKALDWAYTEKLEKYFPLAVVMCDINGLK
EINDQKGHDAGDKFIVQTAQTLKSVFEKRHVYRLGGDEFIAVLPNITHPAFQKLLETAKS
QLGATASLGTTISGTKDTDFELLLKAADAEMYENKKQYYIVTGKERRKHSL
>A0A1E3AY44|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MSNYVGIGENMQYKRFPLWEKGCLAAFIILILAALLPARSLEAKEDRPVVRVGYPIQQGL
TEIDENGNYTGYIYDYLQEIAQYTGWDYEFVRAEGDINESLMTLMEMLENGEIDIMGGML
YNSRMEEMYDYASNSCGIVYTVLKVLYEDTAFNEASREERPLRVAMIDGAAQRREELEEY
CRMNMLIPEIVPCDTEEEMLQALRENRADVMLSTSMEFMEGLRTVARFSPRPFYFVSTKG
KTDLLNQLDKALQSIEQADPYFSASLYEQYFNPPNTELWLTSEEKKYVETAGTLKVGVLS
DLPPYQYTDEVTGQLKGIGVDLLEKIQEQTGLSFQLVVAPDEKTLNRMAAEGSIDLVAGM
NYDYELAKDRNVAMSRPYITTQYMLLISDRMQNRRLEEMSMAMVDGCGCYWEKTDTGVYF
QSREDIVRAINSGKPYYSYMDAYVAQYYFNKTEFKSLKLIPQISIDSSTCIGVVKPASTE
LLSILNKVIQALPQDEMQSIIYANTIFKESPTLADYIKENPFQAAAAAGVVIFLIIAALA
WGIFTKEKLNRKITLELAKHREIYGLVNDYFFEYDIKKDIFTISMKPDGNGEERTAIYNL
KSGTDEKTDYRKQLLEIMVPGKDGIRELQLPEYKQNQTEDKLTLIWIRLAMKTIYDYKGN
PVCIIGKMNDIEEERRERDKLKNQAERDGLTHAYNAKTSLRLIEERLQCLEEGNRGALLL
IDIDKFKNINDTYGHMAGDQVLCEVAAVLRECFREEDIVGRPGGDEFVVYMDRMKENKAL
ADTCERLLQNIRKINAANAGKVTISVGAVVTKRGDRYDEVYKLADNALYRAKREGRDGFF
IA
>A0A1Y6MB10|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MTMDRKQKTIIFLIVTLIITIFGVVIIENINSTYNKQLIHEINNKAKENLAALRFELEST
LVNDIYLTSTLADIATIDFENRNEVLNRISEAVIFKSGHLTSVGFAKNDIIDFVYPFENN
AKAIGLVYKNNPEQWKDIKKARITKQILISGPISLIQGGKALIVRVPVFYDYPNNNRYWG
VISGVINYDKLFETLTAMKNFEKYDLSIVDVSDSQQQNFIYGQPKAIDNYLFYEEVKLPY
GKWGIYLSDNKRNSDYFNDNVRIIAYPLLICFIMLFLSIALLYITNEHRAYHDALTKTPN
RRYLIKKLAKIFKQAKLGNIDGTFIIVNIDIDKFKHINDSYGHAAGDTVLTVLSKRIKNN
LRKNDIVARLGGDEFLLLINFKNDSINIKDRVIDIVKDVTQDAILFDGKQIPISITSGYV
VYDESIANFWDMLILADKAMYNKKAY
>A0A8F9I1M4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A6M3NY99|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3ANP1|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MAENRKRFTEDFTSRILEVRYTDLEKEKRLCLELLVLAKEECDLYGEVFALAYMGDYYIA
VSDMDRAGKYLLKAQRMFPEDQDWEELRLGLTSLLGIYYDMRGDEQNAIDYYLKAVTIAE
ELGDADRECVVLNNLAFAFQRHRCYEVALEFYQKAYWLQKNAGINPVRSILLENLAEVSL
FLRQYEEAKEYILEFEENEKDPLQRVVMGDKNWCCYYGAVGEREKALVYADRLLRNQDVI
NENKMTAFESYHMLCRSMMELREADYAGRFLEAMEEVSVGGGLDQVQTLEEMRIQYSLLF
EPPEKHSEAYCVFYKKNQQFRAKIDETIAAAMKTRIQLEQLMQQVEDMQSEQEILEREVN
RDELTGAYNRRFLETLIREHTDGAAEESFAFIVMDVDCFKEYNDFYGHLKGDEALREIAA
CMMEGARERIYASRYGGDEFVCVCIGLTEKEIRTYIEGVRARLHARAIPHEKSLCSGEVT
LSAGYAAGIVKTQIEVRQLLQLADHELYKSKNSGRNTFTGKRVDIL
>A0A1Y6MNE8|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MKLRLKSSLALLMLIISVVPAAIVGGLLLKQQSDVEANYRIDMLDRLATTIGQEFDYRFS
LLSTSLDVLSRDRLFVQAINNYFLAGHVINSLGTLVKNTPLTKAAYLVDDQWNEIESYNG
IPGLNSFLQLKKALNYRLSTKGKERLKQWVFYYNDEKLMPNKYNPTRRGVVVGVPIFRSM
TDELKHLPLGYLILVVPIENIEKVLKPYLKDGERVILKNNQIGDMKNMADMSNIIISQGG
IAENTPTIQKTITVKLENKYISEPIEYTMVVYMDKYISKNPYINSLKYISLFGSVIILLA
FFSAGMTYRWIARPLGGLMATVRAYSQGEYQRSNRDLRFAEFFMVDKLIRNMATTIQAQV
SDLATKNTELNIAYKEKEQANLQLVDFNDELERKVEEKTLALSFSLMREENRRSMLQSLL
SFSHDLQANNNIIEIVMTQVVALYPTAGWAMKAYTYNNGAWACENIDNDYLENNNIQPES
HYSDYYCLPKDDEYLHCFKIKNSHNEVVGMIVMQYEKLQRDDFEVISLFIRQLSTELEGR
LLNSELARIAVTDSLTGIANRKAFDHDLEEHIQLSYRYPERHFGLFMLDVNGLKRANDNY
GHSMGDALLIQTSKLLVEACRLTDKVYRLGGDEFAIILEAGDGDSCAVLWQRLEAVRENT
HYASLPSGQSVEVHFAMGYASSEINSTDQLCSIADKAMYKDKRRFYKQRGIQR
>A0A1E3AMS2|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MIEKELCALTKQLMLTCMGGRNLDKIQEITGFFTNNAVVIGSRSDEFYTSVEQIENALNN
DKWKEGRNYICRPVKEWFQCIPLSEKVFLVCGNIRLEMIFGSGDAGEAAQDYRAGLSEAD
VRVSVVWKLEKEQIHALHIHFSLPEEDFLPCRAEDLTGTAADEYHGSVDRKEAAYYKKLS
ERDLMTGLYNRGSFEKYVKLQLNEVGGGTFYMIDLDDFKAVNDTYGHVAGDRVIAGMAGI
LREVFGESAVIGRLGGDEFAVFENGSSSRKESEEKARRVMQAYRLMSEKYGNEILLSCSI
GLYREKGKETFENLYSCADEALYFSKNSYKGTFHWYYRQCRT
>A0A1Y6MEQ1|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MRNNWMHSLSLNQRLYLPLVFFVVVLFIVFQTLSSYQYIESEKQNLVNRINILSTGIGAN
LTAAIQFDDAITGQEILSAFSADPMLVSVSVLTAADTVFANFNNTDKLHTSTNNAEELTL
TKQGHVFSKQHLYMLVPIYMDETELAKMRIVVSLDGLHALKWSQLEISLYLLVILVLLSS
FVIHRLRHWMISPIRQLNDAMINVIHFNQTEMVQQQSNSKDEFSKLINYFNTMIIKLNQR
ESKIKHTIVQLEYEKAFADDVISTVQHALLVVDHAGHIILANDSCSKLFHDSPQALLSKH
ICDVINPSDPELFQQSLQNALLGKKQFNHELIKAVNANGTAIYQLVSHPLSHKHQTLFAL
EDVTEKSLAERQQHLAAKIFDNSREAILLLNSHGHIEMVNRAFCRLIGQESATIIGKYYR
SVLTDTDDLPMKKDILMALALDQQWQGECLFYNRNKKVSTPLHLKINKIIDNETNDSQIV
VLASDISSVKEAQRLAYIAQHDTLTHLPNREFLHHYLVEKLALPRTYVMAVLFIDLDGFK
FVNDSYGHEVGDHVLQIVAKKLMQSVRQNDIVTRLAGDEFVAVLNPVKNREPIINIGERI
IASISQPIHIKEHIIHVGASIGYYYIEPEDVTGIDNVLHCADMAMYQSKMQGKGCITEFN
PVEEVECV
>A0A378KQI4|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MAEQLQKVVCAIKLPHPDSNISQFVTISIGVACCIPHHGEPIKLLDLADKALYRAKTLGR
NRIEVIDATKLK
>A0A0J6V9F1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MRAMHSGQPVHGAIMGVHRPGHDEAGEHVWLTVDSVPIDFREGRPHRVVTRFAMITDARA
VALQSAASGHLHRLLIDHAPDIAAWQLPDTTFLWVSSSSKSILGLEPEEIIGRTAHELMH
PDDVAHMRNDLAAGVPSSRTVRMRHRDGCYRWLDVATQVIRDAAGEPAQLRSAWRDVTDR
VEAEQERDAAARMIRSVWTSSPIGIAICTATGTIEDANLALCVMLGRQRGDVVGCTLRAF
LHPDERGRDATIPRADEGRGPHHSETRYLRPDGTAFWGFRTTVALDPRIGREPRYLVHLQ
DVTLRRIAHEKLLHTASHDALTGLANRTAFDENVERTLKRLPPDACSGMLFIDLDGFKSV
NDTYGHHVGDMVLQAVATRLERAIRKGDLAARLGGDEFVVCLPTVDDAEEAVVVARRVAA
LLSAPYDVEAQTVEISVSIGVTTAAAEQRALLVRAADRAMYRAKSTGNAIATVRAEGEGR
CRPSAGP
>A0A841GGW7|diguanylate cyclase|EC 2.7.7.65|Thermosipho japonicus|TrEMBL
MKKILLVDDSKFWRLLLYDLLKSNFEVYIADSGFDGIKKAFEYYPDIILTDYNMPDISGI
FLSIVLRNYNEFKNSGIFILTSSDDKLDDFWVKKSGANKFFSKLIFKEKDKLDDFLITLK
MNDFYSIKTNNHKISREKIYEIIEQKLKSEIFQKEILNLLKFVRDEKHLIFRLYIFFKDL
FDIDSFFTLLLSESEGRIYSFNGNVSKNHAKALLLSYFEKPTIPTTWTFIGDFNDNSSKK
IKEHEKFLIKFENKEEGIILVKPGLNNFKSMTNLISTSLGVVFNTLNNFKEYMNASIFDG
LTELYNKKNLIIKIEEFVKKYSTNSTIAIIDIDNFKSVNDKYGHVVGDKVLKKLANIIKN
TIDKNAIAGRYGGEEFIILFNSPEIAFTTVEKIFDTIHKTDWGGILNDKRKITISCGVSS
YKMNQTITDFIDSADKLLYKAKKDGKDRYYFENYNLMENKYIV
>A0A7L6CLU4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00994|TrEMBL
MNKQYQRVLITTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACTLGNISASWLLFSWDAISFVYTLINVVEACIGAVMLRKLLPWYNPLQN
LNDWIRLALGSALIPPLIGGILVHFLVPTAEPLRNFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPQLLLETLLTMAVTLALCWVAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMMVSLMMAQNPIPMATQNSGAMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQAELQSLTFQQLTWPEDLNSDL
EQLEQLVNGDINTYTLEKRYYNRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHEAML
PEDRDHAEKVIRDSLMARLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWVQTEAMGQPI
LKVLHITFGDNGPLMENIHSGDMSRSDIEQDVVLNCRSGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIHSINNYHFMWEGRLHRIGASAGITLIDENNYQAAEVMSQADIACYASKNNGRGIV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEQAFRSGLAESELLHALDRRIFSEFFRAYATQVASKGMGVALPLSEAGLSSVTLV
DELLDMLEKGALPGRLLHLVISIEVLNNPDENVHQGLQKLRHAGCRVVLSQVGRDMNILN
QLSAHMADYLMLDAEVVTNVHGNLMDEMTVTIIQGHAQRLGMKTIAGPSNQPMMMDTLSG
IGIDFIYGDTIAEPQPLELLLNTSYFAIN
>A0A2S6Q345|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
IFYLDQLTGVENKKGLIRQFAKYQDEGIKFDLYYMDINKFKQINDTLGHNVGDIAIIESV
HAIRDYANNNSGFAYRIGGDEFAMLTTSNKTEEQIIKDIKDIIKKPIKYNADGKSGVLEL
SISIGRANIIKDDDVKIKQVIQSADKNMYKDKTK
>A0A5B1CGA6|diguanylate cyclase|EC 2.7.7.65|Rubripirellula obstinata|TrEMBL
MTPIIDTNSSLLGGPSPNVLPLIPNPGAANDPSVDQQVADSAQNAPPKNAPPKSDSATSN
EEDHSRVGRLLEGLQQSSPRAKESDSPASEVRFENRLAVVRLGMATSLFYALRTKHAATA
AHCLRVALSCSAWTERMKLEDELRDRIEVAALLHDLGKIGIPDRILRKPGKLTVDEQLSM
DLIAPLGCEILRGCTGDQELLDIVLYAGTWFDGRRLDDGPSGAKLPIGSRMLSIADAFDS
MTTDTVYRPALSRERALEELNKGGHTQFDPELVADFSRMLEERPELLQGCVVNRWLHGLA
DDKSQSMWTGPATIAAGAGLPTSGSLAAGQTTRRETLFYHQLLDNMKDGVVFTDAEGIIT
RWNDVMHELTSITAEAIVGKRFSNETLRLRDLSQKRDGGDECLIAETINSGLSTTRSLLM
EQPGREATPVQLTVTPVSGAEPGIHGAVAIFRDMSDQKTMQRRIETLHEKSTQDALTKVA
NRAHFDDKLKEMTSKAARGKSKFSLIICDIDHFKSVNDTHGHPAGDEALIKFAAVLKSHS
RDGDLVARYGGEEFLLLAANCDNATAASRAEAIRVALEKTPLPSLQNESVTASFGVTQFQ
AGDTAESVLARSDRALLKAKDNGRNRVIQLGSGSEQAVTTDQPKSGWFSWLSGSSVEKSG
EFDIVTPVPVDLAIEKLRGFIADHGAEIIVVKENQVSIKVNATYSSGGRRRVDQRMAIQA
QLTLSETAQSRGTVANPGKSLPSLTNVHVNLKPLRNRDRRGRDVTACYSQVISSLRSYLM
GELKRQEG
>A0A811XM18|diguanylate cyclase|EC 2.7.7.65|Citrobacter europaeus|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADYSSSLLSDAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATAMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
NEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKSV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A0T9NVC4|diguanylate cyclase|EC 2.7.7.65|Yersinia pekkanenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSSIFSMILPSPETPAVTLPIVMITIISLSAALY
LIFISKNYADKLNLFSIIMGVLWAWQIILKYEYLGTNENNYLLLSLFMIFFISTIALSDN
FLAFCLHTAPSALTVILLDDFQNIFRIIFTIMLPLIGFYLHHLMLRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTGLYNRRGLENKLETLLAQSPVNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAHDLASSLKAADEALYRAKKDGRNKVAFAGEQLSKVESSS
>A0A087A9Q1|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium callitrichos DSM 23973|TrEMBL
MTQDELEGRTIMIVDDDQALGEMLSIVLENEGFRTVTCLDGLRAVEMFPTVEPDLILLDV
MLPGIDGTEVARRIRATSSNVPIIMLTAKSDTVDVVAGLEAGADDYVSKPFKVVELLARI
RARFRIQPKAAGVVGSSAGARGLVPNGDAGPSGMAQGGNGDPNRIERGSIVIDRLAHTAT
RDGRDLSLTPMEFELLAVLAASAGDAISRSSLLKRVWGYESSGDTRLVNVHVQRLRAKVE
DDPEHPSVIVTVRGIGYKFVPPEPRADA
>A0A1V5I1I4|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.BinA166|TrEMBL
MRMNAPSREGFASVGRTRLFLSGLCFALALAAGLAFLPASFDARGARRQGQLVAEVRFVN
VTLARTALEDRITSAVAQQRFLMDHLVLDRDAPLDDVQRSLLGSIYNTPDVLGYYLLPLP
NQPQRRFSAFRSTPQGDAARDFARILAYKLEEDATPFVEGRQQTRRFMPSSRVNMLALVE
TAPGRSVTWHSIAVLNLAPFLARFVEPLETSAEGGFFVVASDGTIIAHKDGTLVGRNVED
LSSGEGEGLREFWGRASQAFSGMEVVEAPLSSLIGSERKSIVWNSLRMGDERVFIGSYAP
AEGGGAASSEPGALSRPLSVVLPFLLVLAGILVLTAGRRPGGGERGLSRVPSLDDAPVAA
ALLDVKGAVLYSNDALIAMTGRTREQLRMRTIFDLAGETPREEKDRVREALRVGARSSGF
EMLFSNREADPSPAADSFWGLVSLSSPGDGFPAGSMLALVSDISELRQARLTLRHNAEAL
DAGKSELEHLAASQAAFLNMLTRFSECSSIEELFDVLSEHMMPIIQFRCLTLYIRSSRDS
SFSVIDTGGDVVQSNQTDFLDNKKGVLGHVAETGKPYLMGDASVDPYFIPHSREVQSAVF
APALYKDFLWGALILDSERKFAFAARDRDMLSIVASYVALHAEEFSVRRELDKKAVQLRF
LHGVVQKIAAERDNETLASNIVDVLCDELHFPDARFYTPAPKGGGAPVQAAGRASSDCAE
CARGFELEASAAMRSRTLVERMENGKVMVLAVPLVFENEVFGALAARHGAGFSASDRELL
EITAEHMTTFWALNNLIAKRRHESLVDPLTQVWNRRYIMQRLNEESSRISRTSGRGAVVL
VDLGDFKMINDRYGHMVGDEVLRVTSETMSKNLRDYDMIGRYGGDEFLVYLPDASRQGAE
AIMDRMEKEVGRQIIDGFDGAVILDYGIAVCPEDGPVISDVVRIADMRMYKNKERRKAGL
AR
>A0A448KQM1|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MRLVMALALLWMTQLQAAPLLEEAELQAARDPAGYLQRLNAKPRPDMELFHARSLAKAAL
GYYPEALLDNARARGLATARQETLRLLDFRLQQVALTLDTEAPQQALRLLSQLQSSVRGH
PAQESEWHALNGLALYRTQRLKEAIAELKTAFRLKQQIPASPLAGLQFARLMMTLGNLYA
DLSLYQEAEGYYRDALQQMVQLDEPNSQAIIRANMARLYIDMDRPIQASQLLDGLLATPD
LAPDYRAIVLGYQAMALNAQEKWHAAWRSLDEAQAIYQRLGYPQAGSRLTETRARTLQGR
GEKQLALQLLTAQASPITIDGKALQARLLADLGRYPEAYRVMREYMHDYKQHFNQTLSQH
ASAFQAEMELARSEASNRALQQENERRRQQLLYQQSARNYQLLLVALLPGALILLGLTTH
RLHRNSRHLYRLATFDQLTGLPNRRALLERLSQQWQLNEPLTLLIIDIDHFKQINDRHGH
QTGDLAIQRLAQELKHWAPDLQQIGRWGGEEFLVAMSQDGATCRHHAERLRHRIEQLDAP
RMTISIGVAERSPADDSLHQLIHRADMAMYQAKRQGRNQSILAPSPDQPSPLTSSVA
>A0A380MMJ2|diguanylate cyclase|EC 2.7.7.65|Streptomyces griseus|TrEMBL
METESEPYVRLATLRQLHQVVADLNTARSLADTLQTVADGAVTGLGYEICAVNLVQADGD
LVVAAVAGNSSAEALLAGQVGPRHAWEHRLSIAEHWGDLRFISHTEAWALDEDGVPGWYT
PAPAPRFEDEWHPGDRLFAPLHATGGDELLGVISVDRPRNGRLPGPWGQEAFQMYAFQAA
IAISNARLRANMQRALVRLEREQQALRASEESFRQAFEFAPSGMAIAEMGGDQHGRILRA
NDALCRLLGRRANTLRRYTFSDLAHPEDIGTLLRTSAEGGRTEVRLSTNEGAYLWVSLRN
SVVADATDGPRLLLTHVEDITERKRHEMQLAHRASHDALTGLPNSAELRARLSARLCTRP
HAGRPSAVDTLDAAYGGPAPGMFPGAADKGDAYDQDAHDFGLDLGLGPGGARQSAGPTGA
GFGVAPYEHHVHTVAPDEDGDQESESAKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVA
RRLTNGVRDGDTVARLGGDEFVVLADGLCQADAQDLAVRLRNAIIPPIRVDGRAVRVGAS
FGIGWAHCGMSVEEVLQSADQRMYIEKRSRSKQQRRAG
>F5NUH0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTTQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>A0A8B3W3B0|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MKVNRHFSLTFVFGFPAVIAAMLLGLIGKNHFDAVEKDISSEFNRIEDVFKGTTKVVTAL
DYSFSNYYKSANPLFLDHNKQVVDGLCRIWPIDSLLLADGKTTDIPSVDIDYMLVGEESL
CTETSGTYKSASEKIALAPILSFLSQLDEFHNGVHFIDKRGYVISSPEDFAKELGKELLS
TIKSRPYWQRTANNPDLLTLSGPAYRFDSLDRIISMTIPVFHQGVHQGMLSVDIDADRLL
ASSNEHLAGRIDIIDTTLANPIDTATFYHEIKLEGVASHHAMYYELDLANEVEHFFVYEK
DSLIVAIIVYLFSVTIFFYVNSNIERGYFKELAAKDPMTGLLNRRGLEAFWRSVEHDQLF
ALTVFDIDDFKSINDTHGHDKGDDVIRYMSRQISNSVRSSDVAARFGGEEFVVYMKGDDR
ETLIRTLERVKNAVCANSADIVPNGFTVSGGVCIVETEQNKLNFEEIFKYADEKLYVAKT
TGKDQIVF
>A0A143QRH7|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MWLAPFEEVNRTIMVDADRWYREMFEASTVGMALADEHGLLLLANEAYAAIVGCPRDLLW
GRSSREFTHPDDLDQHAAMEQMMDDAEARGESVHVEKRYLHPDGTVRWGWVSASEVPGPD
GRRWTMAVVHDVTDRRRLEDDLREAALTDPLTGLLNRRGWRDRLSQLTTPRGVDVSLAMA
MIDFDRFKSFNDKYGHGRGDRLLVQFSTAAMQLLAGRAYVARWGGEEFAIAMPDTGSTTM
ATVLTELAAVVPDEQTFSAGYTTLRAGESLYDCFDRADLLLYRAKRDGGARSLGDRSSTP
SQ
>A0A7G4RL80|diguanylate cyclase|EC 2.7.7.65|Legionella sp. PC997|TrEMBL
MALVSLEGRWLKVNKSLCQITGYTEEELLQIDFQRITYPDDLQTDLNYVRQLLNGTISSY
QMEKRYICKNGAIVWILLSGSLIRDAHSAPLYFIAQIQNIDAQKKAEHELVRMAYHDALT
GLANRKQLEQSFLLFMAYAKRHQCSIAVLFMDLDYFKKINGTFGHDAGDLLLIEVASRLT
ASVRSSDIVGRQGGDEFLIILSDIVHEEEVHTVINHLFHAIQQPILIKEQTISISLSIGV
SLYPQDGSDLDTLIQHADAALYQVKSTGRNNFKFYTPFH
>A0A143QKL9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MYFLLATTGLYAVGVILTLLPHGDRVTSDVTGGVVAVGLGAAGVVVLWVRPGTAVALRLA
LAAAMVATPAVMAFHRLAAAQSQCLIAAMFLAMYIRAFHRDGPGRVLVGVLVVSVLSAVW
ASPAPMYPISYLIFGVAVIAAGEAFGVVTKALIAASCTDPLTGVFNRAGWEMAAAEVAGS
RTAELPVAVVIVDVDNFKAVNDSGGHRAGDELLIDLAQSWTRAAPSDAVIARLGGDEFAA
LLTGHSRDVVDEFARITTESLPYASVGTAQSTDPQESVSDILARADENLYGVKHVRRERP
>A0A174IMH8|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MTEYLKKWKDKWSGKNGAFLCGLIYILIMAGMFGCCRMQYGGAAGGLIAAVFVVSLAAMA
VMTVISYPVRREKEIMQECGQEQDGQEVRDALYRRLGEFADTVLFEYRYRDGAILFTPNA
SGQIEIPVLKSVLEKYVKRPPAQGENRCFEFRMKANMEEYRWCICRVRVEYDGADTPVCL
IGKLDDITKQKEREEQLLFQSTRDGLTGVYNKTAFEYMMEETLKRGSRGCLYMIDIDNFK
DVNDQYGHPAGDKILVKIGELLREIFRDSDLIGRVGGDEFVVYSECGETKTRAMKLLNGT
ADFTKEGEHRISVSIGIAASTGEPDEEYQELFSKADQAMYRAKQEGKNRIAWYEE
>A0A549ZWW7|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MCADKTIGQLQAEIKALQDENIELTRQKRSVEEKLTAALDGTGLCLWQQHIPSGNLTIFN
REWGHLLGYTEQELAAHVDSWKETLHPEDRDWVIAAFEEHVSGKTESYQAIHRMLHKDGS
VSWVSDRGRIVEYDDEDKPIRMMGTHIDITKEKRYEIDLARLAHCDPLTHLLNRKALEQA
FYEHQSVSSQAGGALFFIDLDGFKQLNDKHGHRLGDLVLMDVAQILQNKAGERAKLARFG
GDEFVILYPTRDKAVLTEVAESILSHYHTRIQIDGCEVQLGLSIGISLFDGSDPFIAACE
YADRAMYQVKQQGKHNYAFWKIKDPLALISNNEVSKLTY
>M1YY20|diguanylate cyclase|EC 2.7.7.65|Nitrospina gracilis (strain 3/211)|TrEMBL
MKRDIANQIIQEKTFLLEHPEMFFQLFDGLFPFFLFTRDPEGPLISVSNKVTHVLGHAPE
DFMQRWPDYLANHPVNETFKQRACLEAGSAKEPINYKTIFSNKHHEPIWLEMFESPQMVD
GKPDKIIGIALDLTKRSVLENQLRLGEKRFREMSQTSPIGIFQTDNDNLIAYVNPAWEVI
TGRTISESLGQAWWDCIHPGDQEDVIRKWGRGNDKGEEVDAECRVIRPNGTMIWVKIRSQ
ILFDDTGKITIATVENIDQQVADREKQKQLIHELLQLKEKLEVATRTDPLTGLPNRRDLN
DKLGHEKARFERTKRPFTLLIVDIDKFKSINDQYGHDAGDYILVQVGELLRNSCRRMDHI
CRWGGEEFFFLLPETNLENGYVFAEKLRTKLASAKFNYKGQQVSVTASFGLSCVDDDSRD
LESYIKEADDCLYDAKNAGRNRTVARKRKPGAG
>A0A174NM39|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MSDRKRRYKMMIPFVVLFCLLLFSFTAGAAESGTRVVRVGYPIQPGFTEIDENGNYSGYT
YDYLQEIARYTNWEYEFFTMEGTLDEQLSGMLTMLINGDLDLMGAMNYSDRLAEILDFPE
YSYGTAHKTLSVLKDNLEYTEFDYESFDNIRVSVVSFDGKEDEKLNSFAKMNGFHVNQVL
CSKGEESLEKLESGNVDAVLGMDVALRDSELRVISRFDSRPFYFGVTKGNQEVAGALNKA
MEIITTTNPYLSAELNKKYFTGDEGLVLSNLELEYIGQKKTIRAGVMLGRAPLQYQAKNG
EIRGISIAVLKYIEEQTGLTFEIIPFYNWEEYSRAVEEGTVDMAVGIVDDYEGTGTVSCA
LTVPYLSVPLQLIMNDKVEKLADMSGKRLALQKSLLKEQNTAGEVLYYDNIEGCMEAVHK
GEADYCYGNSYAVQYYMAGHNYKNLLTFAQSENSSQKYCFGIRRPVDIMLLSIMNKVIRV
LPEERINRFLYENVYDSGDLTFSEYVMRNPEQSVLYLALFLLVVVTAVFITVEIARRRNM
ARKALENQRYEQLSELSNEFLYEYNIREGTLNLTEQTAGFLGCERKIQNPETMEQKYPVF
GYMISQKENNTEHECLLPGGNVRWLKVISKMVLDITGRPWYAVGKLIDIQMEREIKTQLE
AKAQRDSLTGVYNSATSHQLIRQVLAEEDRNGTGAMIIMDIDYFKQINDYLGHYTGDQVL
EETAEILQACFRTDDIAGRLGGDEFVVFMKAVSDPEIVKQRCFEVLDRVKAVTMEKHGKE
VTLSIGAAMAGGETDYDVLYRKADQALYQIKKHGRSGVLVME
>A0A1V5NDW4|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium ADurb.Bin401|TrEMBL
MQSKIIIDTIKPQPQVLLIGRADKTVIDIEKNENIKIENCRDIPEAISTFAGNQFDVIAI
NTEALDKNLTLSLRNLRQVNPDSKIFLLAQMWQEPLAAHIVAESSNGAKLLDDYYICPAV
ITTSKPPGEEVQPEGSPSQEHLERIAILERLVMEDELTGVKNRRYVREFLRQIIEHAKQL
SLQVTLLIFDIDNFKQYNDLFGHPVGDNILKQAAVLMQKCCRKQDVVGRIGGDEFAVVFW
NLPGENIISLDTNQEERRRIESEHPKQVINICERFRNEINKTDLPALGAEGQGTLTISGG
LATFPRDGLTVMQLFEQADKALLEAKRSGKNRVYLVGSDSNQQS
>A0A383RT63|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MALDPPTMLTISIALAAAAALYLAIEWRTVRESSLLYWSAGFATITVGCTLALLRGNGHL
LIGIWFANGLLVTAHWFFLLGVARFTETRLSRAWYLIFVVWLAMLLLPEGPQWSKLMFLA
NSLLVALPTLRASFLLRPHGMSLSVGAVQLRFVLLAHGLFYLIKMVPPLVPGSLIDLAAF
RGEIIQVSLVEGAMAIMLIALSMTGTERYRREQQIARLAARDPLTALYNRRALEVRAPRL
INAVSAARPGALLLIDIDNFKLVNDLYGHTAGDRLLVALSEMIRALLPPSALAARLGGDE
FVILLGHASPERVHQLGSSLRDQFQQLAAQSYATPAAVTLSIGANLFDRPPASLAALIEQ
GDQALYESKRAGRNRIRLDDRTLAAPAAD
>A0A6P2FSJ3|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. PBL-H6|TrEMBL
MVAALLFVQYQGSRVALRASVERHHARLTERTAAVFEDRLQALSELADGVAASLDEAALR
DKPRLQQRLAQLTLVAPHAFRTLSVTDLNGYPLAWVPATTGPQADASVADRSYFSGVLAT
QSRVIVGPVLSRSLRTHVTIFSSPIYGAEGKVVGVVVGSIENIALAATAGLGDFAGGPAS
LVTVASEEGTIIAQRNADRMGESVRTLGPMAKLFTEAEAPSGLVYGMNADGVPSLMYVTT
ISGPSSPWRLVMEAPVSKIFTDEAELRWHFLVVLSAGTALLPLLWLTIRAVLQPLRVLHR
QVAAVSLGNTVPAMDTSGLHTSDELELAEAVRTISRASTKSLSVEEAETTRLRTALHNVD
AGVLVVDCESRITTINQVAARLLGWRVSDALNRPLDQVYQPRLRASGETMPSLHPALLSA
KTALRRVNTLEAVSRDGKAVPLSEASVPVFLADGSTAGAVIVIRGPSAAEVPAVAGVHLR
DETTGLRRHCELQSVLTKLFNANGPADGHHAVITMDMAGCGDQGPNLGQLRNAGKAVRET
LRMGDRGFRWTEASLLLVLKNCDLPEAAFLAEDVLGKLRASDAQTAPQVSVGVLAFGPGP
ATWTEVVQAATRVTDAARRQPGAVYIAPESNGAGMLDALGDLFGQAPAA
>A0A6B9GBK6|diguanylate cyclase|EC 2.7.7.65|Pantoea cypripedii|TrEMBL
MQEEIEQYIAVILQEWRPLRAALPQEVIAILRQIADTQSDNLAHRFYETLLKDPAISRHL
SYELVEERLSSSLSKWVKAILTEDESQFENLAQLQYHVGGVHARIGIPVEFVQRGARQLK
YGIFAYVAQHDIPYPISLQVMHYAAMAIDIAIEMMSHAYAMSHYRATRNEEAYRMHVLMN
NAWQEQGKQQSALSSWENSVIYNLVSGVPQTEHLLNISESNFGLWFRHKCVRQFGENTQI
QQMRQLMAKIDATMAGIDVTTPIPVEKLQELLRVIHANCQKINTYMEMLFNDVSHMQDGK
DALTNLLNKRYLPIILKHEVSLAMENRLPLSVAIIDVDFFKKVNDEWGHSVGDRALTHTA
NLLSDNIRASDYLFRYGGEEFLIVLVEAGQSETYTLLERVRRIVSNTPFETVSGKNITLT
VSIGYTLHNGHPDYNLLLNKADAALYEAKRSGRNRIVQQ
>A0A649YN08|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MKVKGHFSLKFVIFVPAVIASILLALTVKNYLDAVNRDIDDEYQRIETSLERATKVVTAL
DYSFSNYYKSGTGLLLEHNRKIEDGLCKMWPIDALLLAENKTLDIPSVDISYMLVGDKSL
CQQESALYQNVTDHVSMAPLLSFLHDIDDFLSGVHYIDFDGFIMSSPDTLAKQITKPLLN
STLVRARGLFRKHDISKDNIVIYGPETLTNPAKKRLNISSPVVSQIDYEGLLTLQIDLAR
LLQSEVKLASDIHLINTSNSKPSGRAVREYVLGINGIVSSHMLYYELDLRAEIKNFFVFE
KYSLIVTGSLYILLVTVLFYVNTRVERSYFRELAARDPMTGLLNRRGMEAFLRNTTHSEY
LALSVLDIDNFKSINDAYGHDVGDDAICFMAEQIEKNIRDSDAVARFGGEEFVVYLRGRD
VEKMRMTMERVREAISRYSANVVEGGFTVSGGVEIVRTEENSDFERLFKAADEKLYEAKN
SGKNRLVF
>A0A399E268|diguanylate cyclase|EC 2.7.7.65|Meiothermus taiwanensis|TrEMBL
MTLPYPIILVSSILAVAAAYALDREGIHALPWMMFFIAVAASAYGFRVGLASALGSLAVL
IFFRTTLLDYLVMGFILLLSAYLADQVGRSLRKAHQQAQQMAQLQDVFLQGLEVVPRFGN
REQLLRQLPAMLAQLLQGSRLLVWVPSGTGQLSLLEDPGTRPPEAPSPLVQQAWQLPGQV
HWNAQSAQDRRRASPLGWWVPVAQPELHELAVALRIRDETVAVLQFLSKDAWQQQERELF
FRLAQAISRQLEHLHNLELRRLLLKVADHLASASDKHRIADDALRFLMSALDMEAGAVFQ
YRQGAMHGLAWRIPRELRPQLTPLTRKLPYNHGLTWRAYQSGAAQFFENYSSLPEAIPEL
QALGFESVVAYPVHTRDAMKGRVVLVLGSRKPVAWTRSRKEILLGVERLISSALERVLLE
ELHQRITRLLTEAWSYPSQQVHQHILEAAVELVPGSDAGSLWMREGDEYVCQAAIGPVWA
CEQRWSEAAFLEWYGLARSLALRGQPRILYQTQLLPEGCAVNLCLPVSHQGKVLAYLNLD
NLHDSEAFAEDSLNAVQLFSTPIATLIRELQSREAMEKAALTDSLTGLYNRRAFDRRLKE
ECERAARYQYPLTLLVVDLKNFKPINDRLGHVMGDQALMAVARALSQTQRAGDMVFRWGG
DEFAVLLPQTPKEVAGVVGARILEAISKICLGGVCLSANIGYASFPAEAQTAEALLQLAD
QRMYADKNGTSPKTSTDGLEG
>A0A1B2ACX8|diguanylate cyclase|EC 2.7.7.65|Tsuneonella dongtanensis|TrEMBL
MWGMISPGEASALYRLVAESPTDLVIKTDRTGRIVHATPATAGLGLAFAGDPVGRHLLEL
VHPSCSEAVLAEHSAAIGGHDASGWLEVLAVAQDGAERWLEMKLGALPGLSGALGIFRSI
DDRRALEDRLFVAAMTDPLTHLTNREAFVRMLGHLIDNGAGGHVALFDLDHFRTINLRHG
HSGGDRVLIAFARLLQSLLRADDIVSRVAGGTFGVLLPEVDAATAHAACARVVAAMTELN
EGVNDQRLTASAGVARFAVSADATLREAELALIAAKARGRNRVERARRWH
>A0A6M8ML89|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MYLPRSIGLGIGFFAVAAALYPSHPPTWVWIAMIAHGYGWPHMAFLLARRSPQPYAAERR
NLIYDSLGGGFWAGAMGISPLPTVTVLSMMAMNNIAAGGLRLFVLGSLAQIAGALAAYTL
FLPALFPHVTQLQLFACLPMLVIYPMAIGLVCYRVAVQLSKSKKALEKLSTTDSLTGLMN
HGAWKDRLALEFDKCQTLNRQYSVALIDIDHFKTINDTYGHITGDNVLKQLSNTLCASLR
QTDLAGRYGGDEFCVILPDTTLAQATEILERLRRTVHDHAHSALPDLKLSLSIGVAAHGA
HQTDAAQWLHEADMALYDAKSAGRNQVTPARPSTKVCAHEGAALG
>A0A7U9IGI7|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. AS-PWVM4|TrEMBL
MQEEIKQYISVILKEWQPLRAELPQNVIVILRNIAEEQSDNLAHRFYESLFKDPAIARHL
SYELVEEQLSRSLSKWVKAILTQDESQFETLAQQQYHVGGVHARIGIPVEFVQRGARQLK
YGIYDYITQHNIETELGLQVMHYAAMAIDIAIEMMSHAYAMSHYRATRNEEAYRMHVLMN
NAWQEQGKQQSALSSWENSVIYGLVSGVHQSEALIKISDSNFGLWFRHKCVRQFGETEQI
QQIRLLMTTIDQKMASLDITTDIPVEKLQDLLRIIHACCQKISTYMEMLFNDVSHMQDGK
DALTNLLNKRYLPIVLKHEVSLAMENHLPLSVAIIDVDFFKKVNDEWGHSVGDRALTHVA
NLLSDNIRASDYVFRYGGEEFLIVLVEAGQSEAYMLLERIRRIVSGTPFEAVSGKNLPIT
VSIGYTVHDGHPDYNQLLNRADVALYEAKRNGRNRIEQHK
>A0A1M7Z0P7|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MFFLLSFLYILSSLLILVTTAKFFVDTQSDKHTQAIKQEVELVRFKIESNLYRDAYLADS
LATLITLAPDFALSNWKSVAGRLHNNSETIVTIGLSPDDIIKRIYPEKNNTSALELDFRT
VPEQYADVVKAKLEKKLYLSGPIELVQGGTGLVARYPIFSNPPYNTEYWGGLSVVIDYNQ
LLERSGVLDLEGVTSAIVRDFDVIFGQTLEDKAPDFSYPIYVPNDIWYIYIYLNKEYNSQ
FKEFKYYFYLLGIITFIVIYILGILLFLNFNKVRELSFSDALTGLPNRRYFMLELDRIAS
GENEHLEVALLTLDLNDFKFINDNFGHKKGDEVLISAGRLLRSTVRTSDIVARLGGDEFV
VLLHRFNDEACIKTVIHKIKSKQLSIHSDDEGISCTFSIGYSYFKGKKRDFCIETLITAS
DDNMYLDKAFHKAEKIARD
>A0A5C6DZC2|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MFLDLAIAFSCAAVGLCCGWVMHGVGWLLSSDEFAAGQTSRVTAELEQVKAEQERLSIVA
DRLRDYAQKMAIDVDEHQHNVKAVSDVLSSDQSLTADAMIEAVNDLIEANETMQTKLHSA
QKRIHAQAEQLESAERRAQTDALTSVSNRGAFDEHLTRRHALGPGRAGTLMLLDVDKFKK
FNDDYGHRAGDEVLKVVAQMLHARLKSYGIVARFGGEEFAAIIDGYTVDECKKIVESARV
AISQHTIDFEGKMLRVTASIGVAETIDGESAAQWIERADAALYHSKDHGRDCGHWMNGIC
PERICLDDEDQASEPFLIPEVEDRGPDDAEMQKDGETRRNSSKASSVEEEVPQDKPKNAK
SSFDDELKAKPSTDAEAAKAMSAQPETQSHPKTSGSKPKKGGAKPSAAPADRGAFAGLPG
RAALAGAFCELQERSKAIGMSTQIMALRVNGQPAAGSMRTLLQIVRATLLSVDRIGADDA
NTLLVCIPGVDEEAALERAEQIRASADTVQFAEAADGSGSTLQIEVVQVAQTETFDEAMT
RLADCFVSPVPASAG
>G7Z1L7|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MNAIVAALDLKHHASDRFDVPVGWSPVALASRVGLLRGTERQTLDETIALLSEAKETIAE
LQERIAYLESLTMTDELTGLLNRRGFYSHFRRELASARRNGSAGGLLVMIDLDGFKAIND
THGHVAGDAYLRQVARMIVGNVRQEDVVARLGGDEFAVLLTNTDTATGLARARQLAAIAD
ATHVEWGGHSLPVRFSVGTQPYGAEDSEDEVMRRADAMMYGAKGARRRDAKRRTKRVA
>A0A0B7IYU1|diguanylate cyclase|EC 2.7.7.65|Candidatus Methylopumilus turicensis|TrEMBL
MLMKNKLFSGIFGHFFIRTSIIQSFTGLLLLLVVLPFFNRLSDEMAAEQGRTFSNSTLAA
TYDALYKKEFSQIIDYCMNVMRDTPNILMIVYSNRSGEEIIMTKDNWTLKEKSLPYYKIH
FNHDKALLIGDRPYVISNSHNLFSTTKHFEFSTPVAISGQEWGVITVSFSQEAYFSIINS
FYWAVIVFTILSCGLSLFLFFASSSKIRRQISTFTSMAKNLAEGKLSTRAPETSIGEIGE
LGKAINEMSSSLQEKSSRLFQLVQIVEQTHDAFVLFNKNLNIVFVNDAVTSITGYPTDYF
NGMHVVAFSDALNLDLADLLREIEWMEKHKSNPPSHDIVISKQNKTALPVEMRLEFIEDS
EKSENHLLAVLSSITERKKLENELHQLAFFDKLTGLPNRRMFLDHLNQVIRFSHHNNQSF
ALFFMDLDNFKYINDSLGHEAGDALLIQIAGRLKDIFRSSDMVTRLGGDEFTVIIENTKE
NAQFDVTLLAQKLLDQLATYPIVIGARSFTVNTSIGIAKFPDNGLDSDTLLRHADTAMYA
AKKSGKNRYALFTEDMNSDMREHIEMESALKEAIRVKDQLNLQYQPIVDLKTGALVGAEA
LARWHHPTKGLISPSDFIAVAEKSDLIIDLSDKLLNIAFKQAQIWEGNENSPYLSINISV
KQFAKDDFVDRMIVMLQTFQINAHKILLEFTESVMLDSTNETFTKFEKLKKVGFQIGIDD
FGTGYSSMGYIHKLPIDILKIDRTFVVDVTNNNKSQAIVSAITKLSSTLGIKTIAEGVER
QEDADWLQAFDCNYGQGYLYDEALDIDVFEKKYLK
>A0A4P6M3L9|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MKSIQTKFILLILSCILICSTTIGGAGIINAERVVDEDAAQLMNYRCSELACEMNAILSR
IELSVKTLTAFTDEHLESVERLKSEDTYLEEFTQQLESVAVNAANNTEGAVAVYVRFNPD
FTPPTSGLFWSKTDLNGNFQQLTPTDFSKYSPSDTERVGWYYIPVKNGKATWLAPYSNEN
INVQMISYVIPIYKGNETVGVVGMDIDFNVLKDMVNEVRIYKSGYAFLTDDKANVMCHKT
YPFGVPVGSVDESLLPLVTELENGTSGSSLFSYVNNDVEKKMAFRTLRNGMRLAVTAPLS
EIDQSKNRLLLQILISLLIIAPLSVLVTVLITRRIIRPLKELNTAAKKIAEGDLSISLTK
QTKDEVGTLADSFQQTVHHLQKYINYINSMAYRDALTGVKNKAAYQEAERRLEDQMRQGH
PEFAVVVLDINDLKCVNDNFGHDFGDMLIIDACRLICKSFSHSPVYRIGGDEFAVILEGS
DYDNYMHLLENLQSSIAEYNKNNQQNHPLSIARGIAVYNSGTDLVFSNVFKRADDAMYQN
KADMKHKCKAAASEKLTII
>A0A174HSJ9|diguanylate cyclase|EC 2.7.7.65|Lachnospira pectinoschiza|TrEMBL
MYSINRLLSITIGNNRSYFDVQYVNIAMLVWGCVFCLIAGVGMILSKNFDRRKRLWMILL
QFATAVLLLSDATACIFRGWTGIFGYWIVRISNFIVFLDNNIILYLFHRYVCSFIFTEQE
ERTLKRATFINILCAVAVALVIISQFTDLYYYYDAQNVYHRSEGFIISIFIPVTGMMVEM
SFLIEYRKKLSNITISSLGSYIILPIVAAIIQFYFYEISLIDIAVCNSMIVMYITVIGEQ
DRKLNNLEQKQIKTEAELEISMVLNQCIAELTTEADINIAIHNLLAIINNYFGADRCYIF
ENNYDDNTMDNTYEYVSDSITAKKDKIQKLSMNIVSLWMENFKEEKPYYIADVSKQKEEP
VYNMLHEQNVDRLLAVPLKRDGNIIGFLGVDNPVNHYEDMALLSSIQYFVTNSLEKRVQQ
DRMRYLSYRDMLTGLYNRNKYISIVKAAKDQILKNVGVAYIDLNGLKAINDNYGHSNGDK
FICTAADTFKMVFPDNSYRIGGDEFVIIEQNIERDKYEERITALKNIMQDKQVSISIGVL
WREYVDDLEELLKAADKLMYKEKEMYHNNRE
>K1KJW1|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MKKQDLNLLQQKVTMLRAEGKYKDTIEAGYELLKVGIELKDYKSILTAYINNAASFYCVG
DIEEAFNCIDQYTEVCTKHGDEADWVNLYNVSFLLYETNKDYIKAKETLEKSIQLAGKLE
KYNIVSNGYSNLSHVYMMEGNFEKALEMARLGLEMAKLHKPVSFILAFRVKLNLAKSYIG
LEDLEASKSLIDDMIHEPLLEDFKREKAQCYDLQGAWYTKSKLYAEAYESFTNAKNIVEE
YNDVNLLKTIQEERCKLSELMNNVQLGYTVQKEYIALLNEISERQIALSALKLDIKHRVS
AIKAKANIDYLTGLYNRSYLEGTANEWLQEASINNESIQCLVLDIDNFKGINDEFGHLFG
DEAIKLVSKACSSTLKENELIGRYGGDEFVVILRGATREEGLLKAKQINHSIRNLCINKD
GKTVKIKVSIGMSNNLNRKVETFENLFYSADMALYEAKKGGKNQIRVSR
>A0A5P9H9J1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MIPASGLRLLAGFCLLGAIGAVVAGAFALQAGRHLGADYSALAGDIVRAQEDTAELRLEL
DGLIDHAHHAWHMDRITSLVERIPERIRTIRVGLARSEINAADYAPMLAELTQAEGLYRR
LASTLDTLAPSVGDDVRQLNRLGHELEGSLAWTYSRLLQEVHQAAADQQRLMTWLSLAVI
LLVLLVAAALMLALVRIHRQWLSLRQLSVTDELTQLANRRQLWEVAQRYLELNQRDGGEL
SLLLIDLDHFKRINDRYGHPAGDAVLQAVAAEFTRVARESDLVARLGGEEFAVLMPNTGT
EGGRRLGERLREATADLPLPGEAREHRLTISLGLATTLAGREALAQLYSRADRCLYRAKQ
NGRNRLEINAQP
>A0A7U9RR27|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MNDPIKKLNYKLYILICVTICIFLISIFVYDQTTDTRQQQSPNAVTKWKDWQKTLYKKKT
VVSGKISADSAIGNILAFYSVHQNVKVYVDSNLIYEYPVSNNNPLSDSPGYCWNFVTLPD
DTNNIEIVFTSPYISYLKKIPTFYIGNNISLLAHITTSNILPFLLCMIMFVIGFILVVYH
LFVSRNISTSGKLLKLGIFSIVCSIWSINECNITTLLLKNSLVTSYLAFLSLLLLSFPFA
MFVQTFYEDNSKIWNWFCKIDLIQIILCIVFQLIGIADLRETLWTTHIMMCVLTGIIIVQ
SHLLIKNGIHSQMVKIHLTCIVICSLTFLLDIIGFYSGSWNTNTFGRLGFLLYIIVLGLA
STRESALLMKMGLEANAYQTLAYTDQMTGLHNRTCFNIDFAELSKKPEDIAIIDFDLNNL
KYTNDTFGHSAGDLYIKNCATIIYEIFNGIGKCYRVGGDEFVVLIERASTIDITHYMAML
ESSVDVCNRENKTLKMQIAYGYATYTAKSDKNLEDTYNRADKIMYINKKDKKEQQKFERI
>A0A5E1AV41|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MALHSRKLSFTRPIMFSFAGILCSFALIAVVVTLSQQKDFLEDYHKINGNFTHNLAVNYT
ESILRENDYILGRSALYFARNDTLNEMLNVNPSQGLQMLMHLQNLMPTVSSISLTDIQGR
YLRAPEVLPTEKSKTFDPRTRPWFIAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPE
GRLKGTIAFHLDLTSMGFTLRQMVAPVQGEFFVVERDGAVVLHPDPGALFKQYVSEALMD
KMTSGEGHLYDKKTKAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHESRTVLMTIINAIKTGDVNQAPRLEAMLSHTIQSNKAREMAYVRQATHDA
LTGCKNRRAFDSDVDELLSAHQPFALALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHNVSVYRYGGEEFAVIFQADQIASAFSLLDAWRTAVEKRVWREENLRVTFSAGLGEW
HFEPLEELVGSVDNALYSAKQQGKNRIIRTSVG
>A0A174HYX4|diguanylate cyclase|EC 2.7.7.65|Lachnospira pectinoschiza|TrEMBL
MVNKDLKKNSKIRTVNMMIQSALIIILIVLVANMMVEIKNLQGTARVINYAGLVRGATQR
VVKLEVIGNSDDELIEYLDDVLADLKYEDGEYNLVSLRDTDYQKKLDIQIDYWGKLKNEI
NNVRENGVDNSDIVDMSEMYFSLADQTVSAAERYSEGIADNIHFIETITVIDMAGLLLLI
IIQMIQAIIIVRKNKVLEQKAYLDAHTGLPNKSRCEEVFHDLRFLDRNVACIMFDLNNLK
IANDTLGHSVGDQLIVNFANILRNVIPSKEFVGRYGGDEFVAVIRDMPKEDVIGVLEKLK
EKVEDFNDHGKNIKISYAYGWAFSDDYTECTLRTLFDRADKHMYENKRLVKLAQQ
>A0A395R5P8|diguanylate cyclase|EC 2.7.7.65|Halopseudomonas gallaeciensis|TrEMBL
MPRLSVEQLSQEWGLLNQRFSGHTRQFVLNFCTRHALDLTETFYSEMLVDPAAALFLSHE
QVQGRLSQSMRRWLEGLFDAEAEGGLARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIELLHEDRELSDREHLDAARLMSDTVDLAMEIMSHAYSASHDRNSRNEEAYRLFSVTQN
IATEKESQRAALFDWENQVMFDQAVGQPGAHLPRILASEFGLWFRHKGAHAFEGAREAGL
IIELMEHIDDVILPLFDGTTDERIARLRELRETVKSIRFNLDNLFEQNNALEAGRDVLTR
LLNRKFLPVVLNRQVGHARSHASVFSVLALDIDHFKRINDSFGHEAGDRVLQQLATVLVN
SSRAGDYLFRLGGEEFLMLLVDTDLSGARRAAEKLRRSVEREVFRLPQERTLNVTLSVGV
ACFNGHPDYQQLMRRADEALYEAKHSGRNRVVVVE
>A0A7U9DG52|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. KTE159|TrEMBL
MEMYFKRMKDEWTGLVAQAAPIIRTKAAEIAVTHAHYLSNEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFNQTILHAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASETDTLRTAERIRSRVEKTKLKAANGEDIVLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A727YR72|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:g,z51:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A1J1LSE0|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MVNFKPSELELKQEVDNLRYQLSIAEETLRAIGNGEVDALVIAGSQGEQVYTLQGADSSY
RLLVEEMKEGAATITTDSTLLLYCNKRLAALVKTPLKKLIGSDFKQFISPSDIMLFEALC
QKASLGSGKGELILIAADGTEVPVYLSISILNQKGVDVGCLIVTDLSEQKRDEELIAQER
LTRLLLEQAAESIIVCDHQGKIIRASEESHKILGKNLLLSNFDDMIKLELFPNSNGGQSG
LGKENNSMFSIASVINGNPYKGQEVLFLRDDGKTFNFLMSASPLSIPHNSFKGCVVILTN
ITERKWAEEALKKINEDLEIKVSERTAELESLNHRLKQELLEQARTQQILQDQTQLLDLA
NDGIVAVDLNNNITYWSQGAEKLYGYSKLEALGKNLVKILNTQFPKPLDKIHQEVFEKGN
WEGELIQTNRQGNIVVIHSSWSLKKDGDGNPIAILKINRDITKAKQAEQAIIDSGLRLAG
ILDMAQDAIISINEEQQITLFNQGAEKIFGYTANEVLKQPFCLLISKTFIERHDQSNLEL
VSSNCCLFKNIKDYSEVIGRRKDGTEFPAEVSISELFLDQGKILTVFMRDISDRKQVELA
IQKSQEDLEIKVQERTLQLATSNDELIREIAERKLLENQLHQINEELEERVEQRTQELAK
AINDLQQEAIERQKATVALQDSESRFRAAIDGSLDAFFLLQNCRDEAGKSIDFILVDMNS
KAEEMISQNKESLLGKGLYEIFPWGQWGYFDKYLRGFKTHKGFEEELAVSDPNVKAKWVQ
LQVVPLFDGLAVTCRDITERKQTQEAAQQANEKLTRWVNDLKQRNRETVLLGQMSEFLQA
CNSTEEAYQVINELLKPFFPHLSGSLFVTKNSKNLVEMVASWGNLEALSESVFSPPDCWA
LRRGRSHFVASPKSHLLCKHIYKKLHRSQLKLINSSEIGRALTTAIESSGVPLPAVEHLC
IPMTAQGDALGLLCLASQEPGQLSEDQQRLAIAVAEHIALALANLKLREALEYQSIRDSL
TGLYNRRYLEESLEREISRAQRQKFCLGVMMIDIDHFKHYNDNYGHDAGDIVLQKLGAFL
QQHIRGSDIACRYGGEEFTLILPEVSLEILEERAETIRIEVQNLKLQHHYQDLGQITLSL
GLAIFPAQGVTGESILRAADAALYQAKQQGRNQVCIFSQSCDHFA
>A0A5B8R4Z2|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MKDEGYTSLGRFIDLLLDAICVVDKSGCFEFVSAGAERIFGYTPDEMIGMKMLDLVLPED
RERTLAAAEEIMASRYKVDFENRYVRKDGAIVDILWSARWSEEYQQRVAVARDITKNKNA
ERRQAALYEISEAVHLAEDLLSLYGHLHQIIAKLLPAENFAIALYDQDLNQLDFPYRIAV
AENNVAHFGSVNLFAEQIIQTGESSLFCPVCETYTFPVGETPINPHISWLGVPLKLQKGV
IGALIMHSTPGARTYTAQDCELVEFVSSQIAFAIERRQMLARLEHIALYDQLTHLPNREL
FYDRFQKALSRAHREASYFSLLYLDLDKFKWVNDSYGHSVGDMLLQITAQRLLGCVRASD
TVARFGGDEFVILLERVDSAHNTLLVAQKILETLSQPFELADHQIHVFPSIGVAFYPEHG
RDEQQLLSCADDAMYKAKKNGGNRIELGYPGLRGKHLEALMV
>A0A1J1LJ47|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MDLLLGLNALLSIVYTYLPAYVWGLSLDFDRNVSHQQLKLQLYEEKQNCKQLENRLRSQE
KYREIVETQTELICRFLPDGTITFVNLAFSRYFNQSFQELIGKMIYSLIPPDEHQPLKTY
LQSLSPQASVGTYKHPIILSSGEVRWQQSEVKIILSLAAQVNMAIQQSQLYHKLEEVNQE
LHRLATVDGLTQVANRRYFDTYLLAEWARLAREKLPISLILCDVDFFKKYNDKYGHLKGD
ECLKQVAEILEKFAQRPADLVARYGGEEFALILPNTDQSWAFTVAKLIQEKLAQMKIIHP
DSPHHYVTLSQGISSCIPCPNTNIDLLIKRADDALYEAKAKGRNLIIVYGMELTTN
>A0A841I258|diguanylate cyclase|EC 2.7.7.65|Deinobacterium chartae|TrEMBL
MLTSLILNLGLLVALAHLGSLTLREWPLKRDRAHLLLHTVLAALASTVLLRFPTELQPGI
PVDLGHVPIALIALRYGLLPAAMAALPALLTRTATGSPEAAAALWGLLGVLLIGSALGGL
LRRRRLKLTSAWWVAPLTFSTNGFGLLLLPDGAALLQASYLPLLLFNSLGLVAVVGLLQA
RLRLLRLSHAYRQQALRDPLTGLANRRQLLEDLETLGPEDGLLIVDVDRFKGINDACGHE
AGDRVLCVVAETLERSVRPGDRVYRYGGEEFVLLLRQVRRENAAGVSARLLGRVRSTSIE
DLPNVRVTVSGGLAFPIEGEKPADTLRRADEALYQAKDAGRDRITLARTVHQPDTEPDPA
SPLEVYAASAPDPLPRLALWRSARDTLALLASDHGLTARDWHALLEAAVTCVPGAEAGSI
NLRDGEHFEIVAQVGFSERLLGTQQSQQAWMHYYTGSEEDWRAARPRVLRAAQLARALRE
SGELTGILVDEGPFAEAGRVHELRASLCMPVVCGGEVVAHFNLDSFSREDAFDNGSIEVA
REFCTQASALLAAQRRRQQARHSHEAALETLGLLLEARDFETQGHTRRVARWAIELGEAL
ELSADDLEALRLGALLHDLGKLGVPDRVLLKPGPLSHTERLEMQQHVEAGYRLVQRLSDV
PAGTLEVVRSHHERWDGQGYPDRLAGEAIPLLARLFSVVDVYDALISVRPYKGAWSEEEA
LHEIERQAGQQFDPVIVQAFLRLCRRTPLSAVAWTDALGSGSRTFGR
>M9YE33|diguanylate cyclase|EC 2.7.7.65|Azotobacter vinelandii CA6|TrEMBL
MPGISPEQQAAEWKLLLGQFPAPVVAQIRELATTHQSELPGYFYEQMLQDEQAMLFLTHE
QVKSRLHGTLRQWIVSVFSMSDDDAALQALIAQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFVLLRQRPLDPEHKLFGQRLISETVDLAMEIMSRAFSDAYDRNSRSEEGYRLFSVAQN
IGIEQERQRSALLDWENHLMFDLAVGQLATQLPRLSNSEFGLWFRHKGAHAFQGSRETEL
ILEGMRQIDEVLLPLFGQPAAGADADQRLQNLRLLREQTKGIIFHLDNLFEQANVLESGR
DVLTHMLNRKFLPVILAKEVAYARQNERSFAVLAVDIDRFKHINDEFGHEAGDVVLQQLA
SLLSNHCRGGDYVFRMGGEEFLVLLVDVTQAHALGVAEKLRQQAAQERFRLPGEQDLQLT
VSIGVALHDGHPDYQHLLRQADRALYEAKHGGRNQVVLARKLDG
>A0A6J4FZ47|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MFKFSDPIEVAAHCARAALGMMDRHGVPAHPNNFIIWYAFVADRDPELTKAINGVLRAGQ
KFSDDVCADLYERFFGTSQHEAELRAVGQRIENAVAQVLAYLSTANQGAAQYGEALVSFS
GELNRDPAPNDLGDLIRGILDETKSMIEVNRQLEERLESSSGEIARLREDLDQLKREATT
DALTGLANRKLFDVALREAALEGEEDRSFLCLLMIDIDFFKQFNDSHGHMLGDQVLKLVA
RTIQDSVKGKDTAARYGGEEFAVILPGTRLIEAIAVADTIRRNVASRKVLNRRTNQVLGQ
VTLSIGVAEYEFGESLGAFVHRADEALYMAKREGRNRVISQTELRGTQALDFEP
>A0A174LT98|diguanylate cyclase|EC 2.7.7.65|Dorea longicatena|TrEMBL
MNGYFCVLTTIDFFVLCFMCILTYLSETLSKKQKRGFFLAFVLIAGISVLEVITLVVDGL
PPGYRWLNITANYLGFGLSPAVCICLVYVLDRKTALRREIRTAVRIEIGYLIFLFVTIPC
GIVFSVSADNIYSRGPHFYIYVIMYFGAILYLSASTVITAREFQNRSRLLIYPLILFVMA
ETIIQVALPELHVTWLCVTLLSVLYFIYCSEMWNQLDALTGLLNQNSYLKQTGGVRYKGG
VLVVFDVDDFKQINDQYGHIQGDLCLAGIAECIKKSYANFGYCYRIGGDEFCVLLKNGGN
EGRCKQEFLQRLQEKRGEIAFLPTVSYGSAPFSGEDIVKVKDRADQDMYQYKKERKNRKR
LS
>A0A840C808|diguanylate cyclase|EC 2.7.7.65|Actibacterium naphthalenivorans|TrEMBL
MPGKILVVDDVATNRIVMKVRLAEACYQVLQADGGLAALDLARRERPDLILLDFMMADLD
GIEVCRRLKADPDTAEIPVIMVTAARNSEEKLRALQAGAEEFLPKPLDELTLLARVRSLL
RARETARELALRDGTRRVLGFDEPAEDFARKGRIALIAARQAQALHWKGALSRHLNAELT
VMTRDGALALSDGGPVPDLFVISADLERSGAGLRLLTDLRSRAATRHSAVLMVVPEGARE
AAAMALDLGANDLVNSPFDGPEMALRLATQLSRKYQSDRLRASVKDGLRLAVTDPLTGLF
NRRYALPHLARIVSRAGETRRPCAVMLLDMDRFKQVNDRHGHAAGDAVLEQVARLLSAEL
RAVDLVARIGGEEFLIALPETSLEIATATAERLRLQIGETPVLLPGGKGVISVSVSIGLT
LCDRPGCAVDVLMEEADAALYAAKADGRNKVTIRNSAA
>A0A378JYH1|diguanylate cyclase|EC 2.7.7.65|Legionella moravica|TrEMBL
MITVLGYELHDKMRHNHNIDTYHALRLKDKRKVLLKIPNNNFTSSENLAILQHEFHVLQT
VNAPPIIKAYDFLPNTPAPILILEHVEGQLLSSYILDHTLELGDFFDLAIQLVDIVGELH
QRNIIHKEIRPFNIVIDTQNLTLKLIDLSASTKLTEESFDSSSFEQFSEGLAYISPEQTG
RINRPVDYRTDFYSLGITFYEMLTNQLPFQTRNSQELIEQQITKKPLSVLAVRRNIPKML
AAIIDKLLEKMPEDRYSSFIGIKSDIVDCYKQWVVKRHVTEYSLGTKDIRDHLSMSHNLY
GREHEVQQLFDAYKRVSQASSEIVLIAGYSGVGKTAVVREVINSIVEQHGYFIQGKYDQL
RRSMPYSAIVTAFQNLVKQVLAEHEGKLEGLKNQLLHSLGTIGQIVIDVIPEVGLIIGEQ
PDVPQLNPVDAQIRFNLVFQNFVRVFATEEHPLVIFLDDLQWADNSSLSFIENLLSDSDT
QYLLIIGAYRDNEINENHPLQLCLNHLNTSHVPHTHFTLQSLNLNNVQQLLQDALASSIE
RVQSLADCVFEKTQGNPFFINEFLKLIYQQQLLTFSYDQGIWEWNLEEIKRQSADDNVIN
LITAKIHLLSKPGQELLKLASCFGHQFDLKTLLVINDHSVSNTAEQLWQAINANLIIPLD
ESYKTLGLVGLNETVSDLDLGNLRYRFAHDRIQQASYDLIASQDRPAIHLKIGRLLLKQQ
PLDKYEDRLFTVLKHFNQSILLVDDTEERHLLAQYNYWAGQKAKMESAYDAANEHLSAGI
EFLEPVNWSKNYTLAFQLYQECAGCKYLLGDFIAADLYFSELLNHAQCATDRLEVYRLKI
EMLSVLGKHTEALHMGLAALREYNINIPEKPNILHLLIAVYKIKFQLRNTKIEQVYLPPM
TDVQQKAIVNLITQLLNSAFNINQKLFVILTCKNMSLSFKYGYTESTSMSIPVYAFIIMH
SLNLYDEAISFVRLYDRLKQEYGASDFEGKNQFVLGTFIQPYQTSFEECNRTVNNAFRLC
CDSGDLVYSNYSKLLLVLHAISAGHNLDEVKKNISLALSFMNRVKITDFITVAKFWEFLV
QYLEDGEFAGINKTELFEEEIKNGKSKTELSFFYSTLTRLNFLLGRYEEAVLSGEQHEVY
AEYDKGLVSHLDGKFFFALALFSYLPQIPKAKRKGYLKKLKRLAFFIDKYASWCPGNYKV
YALLIASELACLDKAHDKALALCEQSIKLALSSGLILIAAIASERAALICLDMKIERVAK
FYLCNAHRYYKDWGAVTKVKLLEETYPALLLNYCGSSDESAVSNPTYAFGDTKNLDMLAI
LKFSQLISGEIRLDRLLQRLLVIVLELSNAERCVLLKKMEDRWIVLAEGNLVHQAIYLNG
LEAADAVNVYPKFILNYVEQTQQPIILNDAAQSEFSGQDPYVMEKNPKALLMMPLLFKSQ
CTRILYLEHRSMSNLFTSDHLNSLHLLMAQIMNSLENSRMFYEVTHDGLTGLSNRNMLYE
LFQVSTKQLTRTQGTVALIVIEMNHFKSINERYGYEVGDQLLIHIASKLKVNLRKGDILA
RIGGDEFVVMLTNAPSNAFLASLIEQLIQDLIIPVHIMEQLIQISVNAGVSLYPVHGTDI
QSLIKLAEMAMNQSRQIGVNRFKIYTAHRDDELNPRDKKQ
>A0A8F9MLL3|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A378JSW0|diguanylate cyclase|EC 2.7.7.65|Legionella moravica|TrEMBL
MTLGEQEVMNRKSQLPLPSEHDRKYRLLTTITVELLVIGINFAALNIYLHFWIIAYFLCF
ASVIAIGNLILLKKKYSIILCGHVLNSLCLLVMTVGNLCLGGISSSYFGWFYLSPILAAA
TIGLEGLIFYSLLSASIVLIFVYQYISPVYQVPAEYLLYIENINHIFIFLLTITILYNLL
KENKLYETVLREQNFLLKADKQKFHYLSNHDSLTNLPNRSYFNTHLQKILDLAVSTQNTV
TLFFMDLDGFKKINDKYGHDVGDILLLQVGKRLKNCFRANDIIARLGGDEFTAVITYKPN
ESISDTIIKRIKQEFSEPFHIKNLDLNCTISIGTAIFPDDATNAENLLKLADNNMYKNKK
IKTKHNKHSQ
>K9NGI4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MNELQLDDFKTDENAAMVLLVDDQAMIGEAVRRGLANEENIDFHFCADPHQAIAHAVRIK
PTVILQDLVMPGLDGLSLVREYRNHPATKDIPIIVLSTKEDPLIKSAAFAAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYMELEWRRSLREQSQLSLLMIDVDYFKTYNDSFGHLEGDEALRKVATAIKEASARP
SDLPARYGGEEFALVLPNTSQGGARLVAEKLRQTVAALKIPHNSPTEGSSLTISIGLSTI
TPKAGSNCRDLILAADKGLYLAKNSGRNQVGIG
>A0A752IS85|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 21:z4,z23:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A399F007|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MQGRVLTVWVIALASALAWLLTHWLRPSERYEVPWLIAGVGALASLYGLPGGLLAGGLVL
GLAAIVVGASYLPWLAMVLLVSVFLSDRARLRLDSVLRRQLQTNRQLALLVGALEDLGRL
TTREAVLAALPELLHRQGEGHASIWVPSGEGFRKVASSGASHLPDAIAATGVVGRAYATG
QTQYVRDVSKDPDYIPPTPTSRGSELALPLREGDQVVAVLNLERTQPFLEEERQGFERFA
RAVSTQLSRLAERLETELLNHLAISLATISSPQVILERALEILAPTLNLHHGGILMQQGA
QMLLMARQGSDGSDSQSSIPFGWGLVWQVYRDGQPVFIESTSTYQGAPLEALLEGLEGLV
VHPIPLPGGERQRAMLYLGDPQPRAWRKAERELLQAACRTIGLALEAALTRERLEGLLCL
ARDTVEAPPAQVYQQVLEAAVRLVPGAEKGSLLVRKGENFYFQAVVGFDLAALARLHFTE
ADHLVWYGGDRSGWQRGEPRILSTAQLSIAEVSRRTAPDDTLERVAAIDRLQANLAMPIL
YQGEVLALLNLDNFHDPAAFDTYSKEVARFFSTPVAAILHEVKNRNLLEEAALTDALTGL
PNRRAFDRRLGEELERARRHSYPLSLLVMDLRGFKQVNDRLGHARGDEALVRVAQALLLE
QRKGDSLFRWGGDEFAAILPHADLLGGVTAAQRYASLVETICLEGLRMGLNIGVATFPEE
ATDHDTLLQLADSRMYKAKEQGVAVLRQT
>A0A2H5W7C5|diguanylate cyclase|EC 2.7.7.65|bacterium HR11|TrEMBL
MREPRRRALVFRLLTGWLQRVVLYLGFRPSGRDLWRTGAVFRVLLTAVAPLMIASGWVSM
SGWDYIRLAAAAWAYAAFVWWVSPRAGVWLDGLNLLTDLTLFVLLLRASGGSESPLTILI
YLWLVAMCVANLRERPGLNLAVLNGVALAALTLGAWGFPRLGPFLGFHGATVLLFDVVAL
GYIRQLQSSRLDALTRTLHRGAGLEKLQEWIRAGRSFRLAFVDLRGFKQVNDTYGHRVGD
EVLQAVAGRLLNAFRSEDLVIRYGGDEFIVATAASDALDRLQRVFADPIRTSIGSLRVEG
DVGLVEARAGEGLDGLLSRADAAMYQVRGTEH
>A0A8K1MT93|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MPQDNTGVNNYRGDILIVDDTPENLKFLSKTLSEQRYKVRSVTEGKMALRVANAAPINLI
LLDVKMPEMDGYEVCAQLKKHNKTKHIPVIFISALDDMLDKLKAFNVGGVDYITKPFHVE
EVLARIETHLSLENAKAEILKLNSELENRVRQRTHQLENEISARQKAQEELLHLALHDSL
TELPNRVLFMKQLGRILEQSKQNNEHQFSLMLLDCDHFKVVNDSLGHLVGDRLLIAVARR
IQTCLPPGVMLARLGGDEFAILIEEDTPMGDRARTLADTIQRELSYPFQLGSQENFTNVG
TGVLGGDRLEWWQCVRYNR
>A0A8I2BV98|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MPGCERSEAQRLARLALLQVVDTAAEPFFDALAAAAQAIAGTPIALVSLVDEHRQWWKAN
IGLPGVSETPRELAFCAYTIQGDAVMEVRDAPADPRFHDNALVTDAPGIRYYAGAPIVLP
DGLRMGTVCVIDQRPRALEPAQLQALQQLARVAAEGLEQRRVMLERETANAQLQQRLRES
EAFLERTGRVAGVGGWEVDVASGTLIWSDQTCRLHDVPPGYRPSLTEAIGFYPLEARAVI
TEAVDACVRDGTSWDLELPLTSATGRRLWVHSTGSVEHVDGRKRLIGAVQDVTDRHRAVD
ALAASERKFRKMFQYSLGLICTHDMHGRLVSINPAAARSLGRSVEQMEGRSLVEFVRPER
HAALRGYLSRMVLDGQDSGVIELMAGDGSLRHWQYHNVLDVESDATVVLAHAQDITNQYR
QEKQLLEWSFTDPLTNCYNRRFLDELDKRDPSVRWGCIVVDLDKFKLVNDTHGHQRGDEV
LVQMAWFLNQPLRTQDRLVRLGGDEFLVLLHQATQAQLDALKRDYVGAIDDAPIRFTLGT
ALRQDGEALAAVVDRADHSLYSLRRARRGTGTSDQR
>A0A2X4WVN6|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MIWLRKNRSGHSRPTLGRVLQRANLGLALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFGDRPYIREAMVLIASKEEVSEAKILDNGGNVLVSWHRPKDGPLHGLEQ
IVAHWALPEPVVLPISHEGKQVGKVWLSGNGGSLLRFLLRVFWA
>W7PHD5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MFYYARSLKTQHNMQMQTSSAWESFYVMSDLILARVSETLATEQSLESLVRQLLEMLEIV
TDMESTYLTKVDIEARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTMFSNDVPE
RWPECEAAKALGITTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQS
IQKESLVTQLREANAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNAIIAFIDL
DDFKLINDRYGHEAGDQFLIEVGKRLTEEKQQDDIIGRLGGDEFLVASLSQPHQDGDNAQ
LTLLKTRLSACIAGEYWLGSVHIIYPGASFGVIEVDPAATDPDSALRAADVAMYQEKKGK
SKTRFLTMD
>A0A2X4UC43|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MKVKYLIYFFTFALMSSFAIFISDELIEAHTDYRDNQLNLYKVSRAKEISEAFQATLLAH
RLKRLSLVNADITPAQWQEADSLAREKIARFKPHIDSKISQQLGIRQKIAALSMLGLMEQ
LLDNDNRQLSYVTDANANLFNINSAYYISQTSKSYYRYTYDTRMIDADSFLFLEAVRLNN
RLNMSLTELIDQVIDVNTNQLERKDAYLKAVQLTGVLNALSTRLIFMKLTYNDVPTTLLV
NEMLRQLSKGQIDRITQGLYTAIDNHTPYSADFIYQYVKNLSELSQRLYQRSFELEIVAS
QHKIYTSQTAIYGLISLGGLIVLFIFLPTLVYCSNISRWLTKTHNNILRLSRGNMNIDRN
EVFYGQELIAISDAIKQLKQYQLEKVTLENEKHLLIKELEASSFLDPLTNIYNRRKFFRE
CESLAARSYPLAFCLIDIDNFKKLNDSYGHDIGDRALVAFGKLLQDAFRSSDIFCRYGGE
EFAVILGNCTLENAREIMSKLRERTHQLTLTLDDGQTVRFTTSCGIAQVNSLRLLPTAIK
QADEALYFCKKNGKDRISIHTPTGFI
>W7PSI1|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MLANRRALTSRYITFCLGCLVVIGILHALFLKLVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLVAIAFAFAGSALLMVGTLTSFPAWLDLYQFNVVNYNDAMIYYMF
RHFLMAVLFIVAAILYPMRDYPLSRLAHISIVSGASLFTACAVGLAWIYSSHSPLLSIDL
VDNETRQFMVLWSHCINISLIVFWVITLVALMFVTRVRNLFWVGGNFLCVCYIVTLSMLL
AGGHAEDISWYRARLFETVATLLIIFVLLYDVFRLYRDSHVKYQQSYQNSIRDPLTRLYN
RSYFYESLNQSLDIARPNRPVSVIVSDLDRFKRINDTYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLANTSSDSAYQVAERIRLKLSSFDKTSSGGQLPEPITISMGVFTA
TSSTITAETCVESADKAMYEAKETGRNRVVVFK
>W7PGT4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MPPRTASDLYSEMKNMSVEERIRFFSLSLAEMHSELQESISQIESMKQALEESEEYHRQL
VETAQDAVITIDHAGNVVNWNQAAERMFGWSAEEAIGNSLGKMIVPEAFREQHARGLMRF
KAGQPSNILNRTIEIAALHRTKGEFPIELSIWPHQQAGKQIFSAFIRDITDRKQREHIAW
LHANFDALTGLPNRRLLVNRLELAIAQAIAHDKEVALLFIDLDRFKPVNDRHGHAVGDEL
LRLVAFRLQSVLREGDTVARLGGDEFVALLPDLTTDDALPTHTAEKISAALAQSFLINEQ
VISISGSIGIARFPHDACDADTLLNSADKAMYTRKRVTPGER
>A0A399FAI5|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MEALLLRLLLLHETVVGCAALPFTEMLQQVQERSCWVFEGARLHLLSPREAQGLPGRGLV
EKPRGYGAYFGGPPEPLYLFLEHPRIQDPTELRLAALYMEHLLSMLRAAGCCQELERQAH
LDWLTGLGNRWSLERRLGQGLPPNWGLALLDLDNLKEVNDTQGHLAGDRLLSKVGEALRH
RGLEAYRIGGDEFVVLLYRPDLECLQQAIQGQSLSLGIAWSEEAEAANLLRLADERMYAD
KRRRKAMAPLRTRPLCS
>A0A828U5D0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli DEC2D|TrEMBL
MILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSL
ADRRLYLAKQAGRNRVFASDNA
>A0A5E4Y6X8|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MPISAVFISIAVLSCVMSVAVLGSLFGTKVPGVRLWCLASALLAIVAALLLTGPSDIVVA
VSSSGLLIASLIGLQGFRQFLNARASYAWEYVALGVILVMLTYWTFLSPHVDARSTMISG
CIAYVRFSIGGAVLKYRPRERPKYAYYFVAIAAILGAVVHAVRSIAYGLGLAHESTFLQP
TPLNVMFLGMATLTLPCLSVGMVLLAHDRLADRMERLATFDDLTGLLARRAFIARAEAIA
RECADKKSTFSIAILDIDNFKSINDRYGHAAGDLALAHVASLIAGAVRATDIVGRIGGEE
FALLLPGETREHAGHLINRLRDIVATSGSCVPGREVMSTLSAGVDAFREGDTLATVMARA
DAALYAAKAKGRNCVVVAPAMDPLPIVVAHGNGAGFGGKTANG
>A0A1X3LKV1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA054|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVAYA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGVYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A1V5LZX5|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin429|TrEMBL
MVAASRHQDTSPCMALIIHTDACSRLDALRCGAWPGFAFCAASSEAELQAALEILPVEVG
IICGAPNDPRLRQLLAVLHAAAPDLALLWVMDTQDAGDLPSDALTLPSLEPNTTFFDTLT
LARRVTRSREETRRAQDEMAVMRELADDLADLRTQAEISACLLETAITLLRRRGYQPSSG
AVLAAGEGAQLTVQAALPPYDACLGCALPPSLSADLAQLVEHQSIRATATQLLIPLCWYG
RVCGVLLLDGSELPAVPPDGLCLLVNQGAAALEGAALFELAAIDSTTRAYTRAFTVQRLY
EALKSAYRSGLDLTIMMMDLDKFKLVNDTYGHLVGDRVLHAAGQLLRSTLRESDVLGRYG
GDEFLLILPNTSIAGGIEVARRLLQSVREFSLEINGARLTLQVSIGIGGISSDAQPATAG
VRPDHAFFHRAMERLITQADGHMYRTKHAPNSTHYAAGLPMSWGSLIASEGLLMV
>A0A1V5LRW2|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin429|TrEMBL
MTHTLSTLEIATPGLARMILEHVPAGIAVLEGPKHRFLLVNPAYEPFIAGKGDVHGRTVA
EVFPEIAETVVPLLDHVFQTGEPFSALDMPLALWRNGSLDETRITFNYIPWRDASGEIQG
ILVQAIETTERKRIEDTLRHREAQLEAILEHLTEGLVVATIDGFVLQWNPVALRMHGFAT
LEEARRSLPELTEIFELATEDGAAVPVEDWPLARVLRGETLDHWEVVVRRRRSEWQRIFS
YGGTLVYDTNGQPLMAVLTIQDITERKASEKRLYYQATRDTLTGLLNRAHFFEHLSHALS
AAQRKRQPVAVMFLDLDGFKPVNDTYGHDAGDRVLQAVAHRLRESLRDSDAIARLGGDEF
VLLLTDYEDGREPGEIARRLLDTVARPIEARGHRCQVTASIGISRFPEDGPDAKTLVKAA
DTAMYRAKTRRGCFAFAGEEPGCLDG
>A0A2X3KZI8|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MNDRFGHQVGDRVLIHATRCIQQAIRTQDIVGRIGGEEFCIYLPNTDLHAAIAVAQRVRK
MLVNTPLKLEDESTLLVTASLGVASHEETPEGDLEHIQSQADIRLYRAKQQGRNRVCWSG
EAELQA
>A0A4D8R1T3|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWADTEPAVRERVTAIALAEAEAISGVFYAILLERPDSNTFL
SHTLVQERLRPSLARWITALFTASTDEAIATVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDRNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRNRTTRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEASLRVKADQLRRTVEEHRFHGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A518D9W4|diguanylate cyclase|EC 2.7.7.65|Pirellulimonas nuda|TrEMBL
MAVPPLDQLCLAAEASGLSAAPVCPSRGMPSVQGRLGMASALFTALRCKHTPTADHCYRV
AVSCSTWGAALRMPEHLRDVLESAALLHDIGKIGVPDAVMLKPGRLNDDEYEIISRHPDL
ASHVLMAAGAPQGVIDTLLEMSQWFDGSNRPIDGRGAPPSVTARMLAIADAFDSMTTDHI
YRPAKTRDAALAELLKHSGTQFDPDLVRSFTEHFAQDQSALREEVGRRWLSALTPHESPV
GWHPEEAIVGPLNSDPTTARSAFEQSLIDNMHDGVIFVDSQLRITLWNTGMQRLAGVDPS
AAIGQLLRPTLLDMAEASGRRMADDECPVTAAIRGGVQDIRRVSILGRSGKHVYVDLHVV
PVRQPAGAAIMLRDVSSEQSLEARCLALHVEMTKDPMTQVANRAEFDRMLEQFIETHLAS
GLACSLVMADIDRFKLINDTHGHQAGDTAIIAFANLLKTLCRSGDLVARYGGEEFVVLCA
DCGLNAAARRAELMRKKLAAMVHECLGNQPFTASFGVTELQAGDTPETLIRRADRGLLMA
KEQGRNQVVQLGGDAVEAKKAQGAWWTGFSFGRGAGATGERRSSGVVEVALVCDVPMNVA
VEKLRGFISDHDAKIVKTGENRLRMTTQCASVDRSMRKGDKPIAFQIDLTLSETHTERCN
TAGLAAGKYVQTVAEVQIRPRRDGDLRRAGAVERARLLLASLKSYLMAKEQTAQA
>A0A6L3B207|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MNSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALADADAISDIFYAILLDRPDSNAFL
SHTLVQERLRPSLARWIAALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSTRLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTTRISAKVTAAVEGGLITPAFVKELNNDVTEIAYVLGTIIGKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKAEWLRQTVEEHCFHGTGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A2K1FQP5|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALADAEAISDVFYAILLDRPDSNTFL
SHTLVQERLRPSLARWITALFTASTDAAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVSELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTNRISAKVTAAVEGGWITPAFVKDLNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRMVEEHRFNGAGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A151AWJ1|diguanylate cyclase|EC 2.7.7.65|Moorella mulderi DSM 14980|TrEMBL
MALEKIQVVDWLRVACKASKLFIYLASLAWLAWFARRPKPGCPRRGLAAMLTGMVVAVAG
LSVDLLGEFFRLPVVLKRVAAELVLFNAGTLLVAWSVALVLTELARASCRYQHEAERDPL
TGLYNRRAFFSAAERAFAKARSSGRTPAVAVLDLDGMKAINDTFGHQCGDEALRQAARAV
QKSVREGDVVARYGGDEFVVLFPSKGPREETLRSRLDKHLKAVCFSGEEIPLSLSVGLAR
FPADGESVDALLAVADARMYADKEAKKNSKGSYRV
>A0A3N4P3S6|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. RIT388|TrEMBL
MAVLPLSVRTLRPALRIHLVFLAVFLFSSFLTWRELHTLKINYEDRQRAALVDMQNGLES
QFQESIDGMIYYRRMFNYALAHPLDADHGRRALLEFQQLRSQPAWQLRLNMSRSMPINGV
SDSWLTHDSLLQRDAARMDAELRAAMEFSFILQFSDPDTDFHTRFWYTSRAGFFISSRPP
HDLSTLAASYATMVSRPWFRAMQATADDAKQLRWSGVYQGAEREGAMLTASTAVFNDGYW
YGVLSMDFTRQRIDALLNRMRHSALQGSVVLLDNMQRPIASLDAADSKALSQQAQRLLSA
QMARQPQGSLRLEHQFISWSKLRNVDGYLLNQQTLTQGLRQDLGRATLFMLSMWLLFVLL
LLLAHQVVIRLVTRLSDLSATLAWRASYDGLTQLLNRSAFFERFEAQAARCRQLNAPLAV
IQLDIDHFKAVNDSWGHQAGDAALTRVAAIIAQTLRKNDLAGRVGGEEFCVVLPETTLAD
AEQVAERIRQRLGAEIIEVSPDGVFGVTLSAGVANSEEQGDYRAQNLQAEADRRLYLAKS
RGRNRVVASD
>A0A447IF86|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MSTALELDMPTLVVARIVSIIVFAIAVPIMTLRRDRPETIMFCLALLMAVFSWAAVIPAV
LTRNIFLVAIYGGCVTSIIALQWAAVVAMTGRRVHRAWFITPPVSAVAAILLLPITAEQS
AIVIAVVLSAQLGAAAVFVLIHGRQVVRPSTAVLLAMGYSVSFVSAMSRPAEAVFLGRID
LYAISGDPSNTWPFFASYIGTTLITLSWLAALKDRAEARLAELAFRDELTGLVNRRALHE
GGSKLWHQSMGQGTAFTFVALDLDFFKQVNDRWGHDEGDRVLAAFGATISDAKPKPAIAA
RMGGEEFCLIYQGADANTVHGFVERLRDEFAAGLRLPDGAPVRFSAGIVQSTDADDGINS
LYRRADQTLYEAKASGRDCAIIGLPQQGRAA
>A0A1A8TLP0|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MHNINELIENVRHNEQIALKFFDIERCILSIGRCDQFVSTLTKEVQKQFNVPFVWINLIT
EAPLAHLVETLEKTVGLRDRVLFTRRSAMIDAIGTGNKTVLVNQDIGHYWEVIPQSYRSI
IGSVAISPLTIDGELVGLFCQADQDVHRYDPTAKDTFLLDQLSIKISICLSNVTAREKLE
YLATRDPLTGLLNRRQLELMLEREFSRCKSQNRDLTAVFVDCDAFKSINDTLGHNCGDEV
LEYIAKRLLKHVYKQGLAFRFAGDEFVFVMPGKSYEQALEVAESIHDYLHANPLRYKSNL
VPITVSYGGASVLSDAPTSYKHLLKLADERLYNYKNNRKRSVPTKVFKFLNKIR
>A0A7T0DT65|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRSGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWEATSFTYLSINLIEAFIGAVILRKWLPWYNPLQN
LGDWIRLAIGSALIPPLVGGVLVHFLIPSPEPLRTFLVWVLSESIGSLALVPLGLLFKSH
YLLRHRNPKLLLETLLTMAATLTLSWVAVTWVPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVISLMIARNPLPLATQNASAMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGVEGQWLQANKALCSFLGYSQKELQSLTFQQLTWPEDLNSDL
KLLEQLVRGDINNYSLEKRYYTRNGEVVWALLVVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHEAMV
PEDRAHVEQVIRDSLMDRLPFKLEFRIRVKDGIRHIRSLANRVLDKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPI
LTVLHITFGENGPLMENIHSGDMSRSAIEQDVVLNCRTGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHAINNYHFMWEGRLHRIGASAGITLIDENNNQASEVMSQADIACYASKNNGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLMLIARSVASPRIPESCNFWLISLRLWTNQ
GEVQEEHAFRSSLAEPELLHALDRRIFSEFFRTYAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKGTLPGRLLHLVIAVDVVRNPDERVQQGLQKLRHAGCRVVLSQVGRDMNVFN
HLSANMADYLMLDAEMVTNIHGNLMDEMMVAIIQGHAQRLRMKTLAGPSNQPIMMDTLSG
IGIDFIYGDTIAEPQPLELLLNTSYFAIN
>A0A0P9HH08|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MNNPKIRQVGIFTESEEITHWLACTLKLTTLSFDSICILNKSSDIAKNSPSLIIVTECKF
RALYNYLNKANTLLPVLVVTRDFNGFRVPNANRLTIDLLPLPAATIGLLEHSIKAVFQDF
KLNQELTKLAHYDALTGAANRLLFQDRCKQALKMAKRNKRAVGLLYFDLDEFKPINDTYG
HDIGDELLKRFVEIVSSVSCETDTLARLGGDEFALLLPDLS
>A0A0P9FNU1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MTAELMKRIAILERMLDNVGACIFSKDLDGRYTYANQAVLNVFDLTEEEVLGKDDSHFFN
LTKSQEIIENDRAVMQTGKVLQKEETSFVKPFNKEVTYRIVKKPIYDEDSKVIGLFGIAS
DVSEQRELESKVHEQNQLLDIVLDNVAAHIYMKDDAREFMYVNAKVASLFGLPVKQIIGA
KEQDILPAEMAAHFHQSDSELFASGKKQTIEETVTDESGNTRHYLSVKVPFEQQGRRSLI
GFSTEVTELYELKEQFRKQANTDYLTGLYNRRYFVEVAEREFKRAMHSGEPFALMSLDID
HFKRINDKYGHPAGDEVLKKIAKNLIGNLRDEDVLARIGGEEFAIILPHTTFEQASKVAE
RIRDYQSSHAIATEQDDVLVKVSIGLVMREHGDETFDSMFKRVDKALYQAKEQGRNRVIA
HVS
>A0A5P9ERP8|diguanylate cyclase|EC 2.7.7.65|Microbulbifer sp. THAF38|TrEMBL
MSLFDPQSAQYLGQLGELEAQLKPCEQISLQAAEAALGEIADGVIVTDPRGIVQYANPLV
SEMSGDLVGLLPGQPVNEGLRLCDSHGEPLNALIPDIPYHEVPSVREIRAYIWRSGENRP
PLEVSVQVMALWDAGTLKNYVLVLRDTSAARRVSTRLSWQTSHDALTRLPNRQYFEGELQ
KLLSQCVDKRQHHVLLYLDVYQFKVINDTLGFVAGDQLLVQLVSLLQRGLSKADLFARVG
SDEFAILLRDCTLEEGGRVVARLRESVQDFSFHWQGSDSRVAVSIGVVGVDRFTPSASQL
LATANDACCSARDQGRNRVKLFGDSRKVLEKRRESTWVAEIHAALREDRLMLYRQPVVSL
KGERELHHYEILVRMRGRDGGVISPGLFLPAAERYGLIEEVDRWVIRRVFHYMAQEQLIG
IDTASYAINISGISLGDDTFADFVLEAMSEEGVTPSRVQFEITETSAINNLERALIFIHK
LRAAGCSFALDDFGRGVSSLAYLRQLPVDFLKIDGSFVRNMLEDEIDSAMVSTIDHLAKR
MGISTIAEYVESPELMDKLCRMGVDYAQGFGIAAASGLPDIGEPQGF
>A0A8H9P7H6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLMWMLLPKETTLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKNISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLSMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVYMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPSSVIKTSPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>I4EZ55|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MGDFRTARPGGGPAARWPWAVLLPRPAELLRRPAEPVERVRWLFALSALSALFLTPVGML
LAGDRWTIALVAVSCSGLAASWVHRYRTREVPLVLDLTDTTCLLLFALSCTQPAIAFGVV
VPALWFRGAYGSNGRVAGYAAGACLAISLAVPLWGVVPGQAPWTSPAPVLGSLPVIAINA
LVARYLALGLFQRDVDHERDRALAAFASRLIGVTDRLAVMAASWVTAEAICRSTPGLRLA
VVYDEGGDTLRVSGTAGGWRRQPSTLPRTLLPPASTGQEAAVITAPPELVLASGVAGQWV
CLPLPDTAGGHLLLGATPRVPREGIVATRSMLAQVALALRTCDAHAELRTQARTDGLTGL
ANRPAFTAALVQALATPDTESWLLFLDLDDFKVVNDQLGHLAGDRLLAHLGGQLRSVLRS
GDLCARLGGDEFAVLLRDAGEADARAIGRRLVQLISTPVQLAEGLARIGASIGVTPVPAG
HAESLVVHQADVAMYAAKAAGKNRVQFFSPALLQLDDRAAAEAELRAAVADGQLVLAYQP
VVSAVDGRCTAVEALVRWHHPVRGLLGPDEFLGLAEETGAVLELGEWVLRSACADAAGWD
DGSTPVALHVNASPVQLAHPQFVDLVRAALAGTGLAADRLVVEVTETTVLDSPAVSATLD
ELVGLGVGVALDDFGTGYSALTTLRSLPIGIVKIDKSFVAGALTRTADAAVVEAIVQMAG
RLGLATVAEGVESAEQEAFLRMAGITALQGFRYLRPAPVAEFGRWLAGNRRPASDGELTP
A
>A0A7D6TK45|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILVASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A2S6R7E7|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha10_Bin2|TrEMBL
MKIEENRAPRVGVASRAQGAKLRAADAAASAGHQVQDSASVMGIPEAELTPKIRMAIMTL
MEEVARLREELNGSRGRIEHLERLADQDSLVPVYNRRAFLRELTRAISMTERYGAPSTVI
YFDVNNMKQINDSHGHPAGDAALRHVAETLIEQVRDSDIVGRLGGDEFGVILYQIDADVA
QDKSIQLAQEIAKNPVPFNDHELAISVTFGAYTFNGVEDAGQALAEADKAMYASKQNGPR
AKAPPQ
>A0A859TMH5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRETAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRNLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A2S6R7R3|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha10_Bin2|TrEMBL
MVTPNAAMNAARAGSPGRISSVVPGALEFVGADLTAHYPGALILIDPQNRAEAINKQAVE
LTDVLNGAQHSYLIALIARTAEAKTAQTDLLVIGDSRASVTIELTVIPLVESDSFLVLGK
DITLEKNLRGALVESRKRYKELIEYSSYFVWETDGDGRFAFVTALGALGYSAGMLVGRSA
RSMVDRRKPVPEPFPFESRQSADRVEVWMRDSAGEPACLLVSSVPMTAEDQGFLGARGVC
RDVTEARKRDDALAKIRVREAMFATMVRTIRDEIDPDRMLNTAARVLAEGFAASGCVIFR
IDAEGNIRESASFGHPPEGPVAEAVRAVENGVSDIEFTPGSDETRALACPTRYQGRRNGA
IFVARSDRRRWATDERALLAGVAERIGIAIQQVDAKDELLILSRVDGLTGLYNRRAFVQA
VEQNMAARAESGGPAALFYIDLNNFKGVNDNHGHHQGDAALKAAADIMTACAKRDDLVGR
IGGDEFALWLNACDEAGALERAAQLAESSEYLADFSEALPRPLGVSIGIALFDPDSNEAV
DDLLVRADRAMYAAKRNPEQEYSLALPAEQSNMGGNDGAIG
>I4F3W0|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MAEPMVPEQLGTPFLRRPWTIALLGGVVALVLAVPTLPAAWSTPPFWAVVAVFVAFVLTE
SVQLDLEFRRQTFAVSPSEIAMVIGLVEVGGVWTAVVRVAVMLLIGARQSLPLPKVAFNA
ASSVIEVCTALLVLSLLPELDLDDPLTWLGLVFALVAATVVGMLLICAAISLSDGWPGRQ
MLLSAVPALVVAPLSVVVGVIALLLTWETPWAWALIVPLVIGVVAIFRQSAHAVRERRTV
QRVYDFARRVELVTPDEAGTREIVNAVRELLNADRVALWLPPYLDEGPQLVVDAADGELG
WYDGPGDPDDLLRRRALAPDCGGPVLSSAARADGAELAALVRRGAREVLGAPVTTAAGEP
GYLEVCDRRSDVVTFDPGDRGALDSMLTHVNAAIRQQQLLSQIRHDGDHDRLTGLPNRQR
LAAEIDALLLAEPATARAGLVLATLDGYTNVTDTLGHAASDELLLVTAGLLREHAPPQAV
VARMEGGQFAVLLPELSLPATERAARRLREAASTRARVAGLDLEVSLTIGVAAAPVHGTD
SGTLIQRADVALLAAHSSGGVATYHPVLDQQSLRRLQLGTELETAMAEEQITVVFQPIVD
ARTADIVSVETLVRWAHPRYGDIPPDDFISLAEQIGRIGPLTDHVLDRALDRCRRWLDQD
IAISVAVNLSARCLSEPDLVARVRGALRHHGVPGELLTLELTEGSVVDDTVRNSNVLGEL
HALGLRLSMDDFGTGYSSLSQLRQLPIDELKIDKSFVLGMSTSQNESFIARSIVELAHNL
GLRVVAEGVEDEVTRDLLAQMGCDKLQGFLVSRPLPEDRLEGWLLARTGVRSAAPGARHR
RLFVRT
>A0A3C0H5E2|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium|TrEMBL
MSAETKQHPWRLKHPIKIVNICFLVVFLCSTLLTWREMVVLENGWTASQKNRIQNIAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAEFSRQRHSDAWQIRLDATRGLPIN
GVSDEHVRKNPLLNRDEQRLERELIAALEFGAILQLANPQQESQHRTFYTSRAGFFLSNA
QHPTADAIASRYHRLITRPYFHSHTQQNNPQRGVRWTRNKEVNREGDHVITASLPLDYQN
QWYGVLAMDFPQGTMNTFLNEAMFRRENGEILLLDNDFQVIASSAATSPAASGFTQRDRE
ILSGEMKQHSQGGMRIGSRYVSWAKLNFFDGMLVRSYSLKQSLSGEFGSILLVLGILWLL
FSLMLLGSWYVLRRMVRNMYRLQETLRWRVSYDSHTHLYSRGAFIERAKRIAARCQHQGL
PFSLIQIDLDYFKRINDTWGHQAGDQALIHAAGILRKALRGDDIAGRVGGEEFCVVLPNT
LLPEAAAIAERIRERLNSKEILARPNTTIRISASFGVSCAIPGGDYDFEHLQSIADRRLY
QAKQAGRNRVCSTG
>A0A8G0WL17|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MTLRKKLLWLFVPPLTLTLGLVYVLSQTMMLDRLDREDELLLFNEAKRLRALMSNSINFD
LDRLQRLAQQMAAEMPVQAVEQATLEQLNFDFLLQLEATGTLQLEQWRPIDLATRPLLLT
TQHADLNNLRSSIRQRATQLSKRHTAQASQVELVVLAGVPLILASVTLTPDQGEARRTLV
AGHLLDASRINTLQAELKGSLQVVPAERYTASDSAQAATSGPDQDQISISSRHVPDERHQ
QVALLFSHSPNEQQLVLELTRERRLYNEGRKAINLFLVVSTAVALLAWLLIYLGLEFLLL
RRVSRMHDEFARIGPDVTGARLSDSGQDELGYLAEEANQTLERLEQSEARDRAILEAIEE
GYFELDTNGEIVSVNRAFCQLLGYKSHSPVGIRVQTLLDDDANQRFLALLNSIDDNRSQV
MSGRLRRVDGSLCHYETRLSTILDAKGEIRGYRGILHDVSRHVEYQSQLLDIAYRDALTG
LGNRKAFYEHLQQRLDEAPAALALLFIDLDRFKQVNDSFGHDVGDALLVQMAQRLRSAVR
KPDQAYRLGGDEFTLILTADAAGAQGLAQRLLAALGQPVTLDALQIDFVTPSIGIAVYPQ
HAQDIDSLIKAADQAMYQAKRGRNEAVLFSARC
>A0A8F9HVZ2|diguanylate cyclase|EC 2.7.7.65|Polymorphobacter sp. PAMC 29334|TrEMBL
MRGLSNRQLTISYVTALSIIALLSIASHLLLERMLAAHAGSAAVVNMSGRQRMLSQRIAG
LAAQYRLGVPDAKTDLVAAVDEFEVNHHALIVGDAARHVPAADTPALQKIYFGGQYPLDP
MVKAYLAHARRVLTMTQEDPALPAEISALAAAARIRLIDGLNAVVTEHVHESERQLANLE
LLQNLLLIVVLLTLFFEALGIFRPMVTRMTRYSNELFQLASTDPLTGALNRRSFDERAGA
ELARAYRYKEPVSMLMIDADNFKRVNDTYGHSGGDQVLVALAAYLKNAARRNDLVSRFGG
EEFGILLPVTDISAALILAERIRSGVEDLRVPFNGSEIAFTISVGAAEVDAAATCLQLTR
DRADQALYAAKMSGRNRVSAAAQPEFELQ
>A0A8G0SJ37|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MPQQPPSAAPSRLLLPFACARPRRTVVLCFLAAFAITLVLAGRQYYQLQQHELEVREHNL
QLQALAIETLIFSGKSQLQFLRHLAERVLIEGHSQPSMRQNDAIAAAMRNSQQPLWGLPV
PKSDAPVRALGDALVASIPGLSREPQQLVEDLHLSRAMSQVLPAQFQGETNLSRILFLTT
SGIVIAYPAVRDAQLEPILRKLASSPLMQLNRANIEDLDIVFFPLPGSNLGSMPHLLLST
PVYLNAVMRGAVIYDVPQTKLQNYLYQTTESDELHTLIDEDGSLVASSDQSFKPFQGNWL
NTLPTARKRLSVPMLFQRDHGTLNLEQGYLQFRELQGIDLILTNYISASDLRAAVNAQID
FLFLGVWALLGLLMFLTLYIVDRLFKGQLRLNRQLREMGLVDGLTQLANRRRLQSDFGGL
LQRLREDQPLALWMLDIDHFKSINDNWGHSAGDEVIKHLATLCRALVRPQDLVVRYGGEE
FCVLMPDTSLADALHMAEQVRAATAKSVCVPDAGTLLAGAPSLEIRLTVSIGVAELRVDG
CEELEDLVATADRRLYAAKKSGRNQVVNHD
>A0A8G0WLS4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MTDEAQRWKEKYLKSIEQQEKLERRWEARLDLLRRGLVRSTLAAEGSDRAVDQCMKEMRE
VIRTDNMDAALAGLIPRLEKAVLDSEQRRETRVAQVSSALTSLVSQLQTLPLPSDVSRPL
KKFAKQVEARASQSREVPLLLGELSGLQGQALSALERPEEAQRPGFLQRLFGNRETEAEN
LQPVLAGVASGVSEVAEVVEQPVPVAQSSVAVAPQPYATVDVDELQTLEATAEVIVEPLP
SAVDVPGVREKLENEAVPALQITELPANLEPEAEPPAPVEPPPGGSEQDVLALLEHSPDE
RQDDQPEVAPVDDEEAHYALPDGTEPSYSSVATHIEETLLGLLDDLTLPERYKVQAQSVR
ERLEHGLNWYELLPVLDDLAVLMLAINDSGQHEFEAYLQQLNERLESFQSHLHEASEGHA
DNTCAARDLDNQLREQVDGLQSSVQGAADLDSLKHILENRLEGLLGTMDEHQHQRDQREQ
DMASRLQGLAERVASMEQEAMGYREHLEEQRQKALIDPLTGLPNRAAWSERVDQEVLEWQ
ENGGHLLMAILDLDHFKRINDSYGHLAGDKVLKIVANVLRKNLRSRDFIARFGGEEFVLL
IPQTTLSTGCQLAESLRAAIEACPFHFKGERVTITLSIGISAFRSGERSEGVLKRADEAL
YRAKHLGRNRVEQG
>A0A378INU8|diguanylate cyclase|EC 2.7.7.65|Legionella cincinnatiensis|TrEMBL
MDNKGILTSKFSKFLLYAIFILALTLVSSMGFLVYRELNKMFDANSWVTHTYKVIQATDK
ILIAILDIDSQQEAYLLSGNKQFIANINKVKFNLKQDFDNLLDSIKDNSEQTKRASHFLD
LTNQRFTQLNQIIQLKMDNKLHTSEGMNFLLQEHDLSNQIKGVAQEIKSVELVLLNERNQ
LAINSAKMTNIAIILGRVVSICGLIIAFILANKELSRSLSEEHSRKNIENQLRSILEGAT
DMIAAVDNKYRYIMLNKAYEREFKRLFGKPITIGMTLDDIFKDSPNSKNKLIKQWKEFLK
GGEFIRNIEFEINKEHNVYEITSSVIQNENNEINGTVHIIRNVTKHVQEQLELKESYKKL
NEGIQALQDKNEQITLLVEMSDIMLACSSQEELCHVMKKYCQRMLHFASGYLYVMHPSKN
YLEIAASWGSPNTQETIFTPDECWAIRLGRMHQVSHSRNELICNHVNASGEHVLSFICIP
LMAQNDIYGLLYMEIPQEPAIAFSQNQQLIITAFSELTALAFANVRLRENLRYQSMRDPL
TGLYNRRYLEDFLLKQIHQSERTKSPIALLMLDLDHFKKINDTYGHDAGDVALKELGKIL
QEDIRVGDIAARYGGEEFIVAFYNTDEETSKARAEHIRQAVSRLQIKYGAQHVGPITISI
GLALYPTHGRTAMELIEAADKALYFAKAHERNKVILYSDIDSKKSHLNKKNEL
>A0A378IVE6|diguanylate cyclase|EC 2.7.7.65|Legionella cincinnatiensis|TrEMBL
MPFSYEEEMIFLFEGALRAIPFNVILALLLTLDLLHNKAPLQLIIWILFIIVNSIIRWIF
CRYVMIKRLYMIPKILTIFVVLTFLMGAIWGACYLLVLDHISTLQEFIIILVLGGMSAGA
IAPLSVYLPAYYAYILPMFLPIITYNYLTFELDRAILATMFLLFVIMLFTSAKINNLLLN
RVFRLSREKQVLIDDLHQLSITDPLTGLYNKRYFESILKTEWSIAQRNHYSLVLISIDVD
NFKLINDNLGHPYGDHFLIYISELLKSSFRRSNDFICRIGGDEFSIILVNQSIKESLALC
DSFNNKFNQNKPQEETIMRQITLSMGLAWIKSNYNLQVEKLITCADEALYQAKKKGKNKI
EVIALD
>A0A388RLU6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. P-10|TrEMBL
MRPRLSALLDRLWEQAVRTPQRFVVLSFAAASVLLLVISAHGLVVLRDHEVQTLQQTQQL
QVAGISSVLNVETERLRSVRNFAQHLIRLQMGPHAVEADPPLQAAYAHRNDDLWQLPAPE
GDAVLLGAGPRMLEGMDGFYRRDEDLLPGLYVARGLSHLLSAEPVNPLVTRKLMYVSTNG
FFVTYPPVPPARTAAVLRRVDDAGFMREHLPHNNPDRTLRWQMVPAADGSGDMYLTVSLP
VYLHAQFRGVAISGISQRSLDAYLTSTTRKGVRSFLIDIDGHLIGASTRDVKGGEKIDAV
VPPAWREATPQEMFSRGSGTLHLGDGSRLMFQRIGSTNLMLVDYFSATDLLLRTASHLSA
VLAASALSLAVLLWVTLQGFRKLFSHYLARGEALRELAETDALTGLANRRVFEARFAIEH
NHSLRENTPMSMLMIDIDRFKRINDQWGHASGDRVLKTLADVVRATVRAIDVPARIGGEE
FAVLLPRTSIEEATQAAERLRKILGQTACGPAADATGKGDIRFTVSIGVSDLGADGTDNL
DTMLMVADRRLYAAKNAGRNRVVSDDRMPEPAGESMPAPAPTA
>A0A514EY16|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MARHNRKLSFTAPIVIGFTGILFSFLLIAVFATMAQRKDLLEDYHHINRNFTHNMATNYT
ETLLRGNDFILSRAATFFARNDELNNAVNVNPEKGLMLLMQLQNMMQTVSSISLADTDGH
YMRAPEVLKTEDSQAFNAKSRPWFIKQAEASTFSRYTSPYIDYFTHHPTISLYKPVISAE
GRLKGSLAFHLDLISMGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSEALMD
RMTSGEGQLYDTNTDAWYYYYSFTNPDWFVIYRVDNSALINLTRHETDIVSWSFALAAII
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAVLFAAGHSDNALMLLESWRARVAQRSWREEGLAVTFSAGLGEW
NMEPLEQLVVSVDEALYKAKQQGKNRITRA
>A0A011MVB9|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MLLLLADRQHRGRVVGDRQQLPTHDPLTEVFNQRHIEILLDDESRRAQRYGTPFAVALIA
IDQFAARCQAVGEEQVLARAARLLCHSLREFDMIGRHGADSFLIILPNVRVNEAMVGLER
LRETIETGSTQGGDAGLTISGGVSEYTGEDVPALIERLASLLASARESGCNRLCVNLDLF
>A0A3R9GE72|diguanylate cyclase|EC 2.7.7.65|Atlantibacter subterranea|TrEMBL
MIKKNMRVEVSTPHPVLRLLSLGLLSFLFTLFSLELTLLGSSLAPLWFPTAIMMVAFYRH
PASFWPAIAAACVAGNLLASLVLFPSNHIVITFPLINILEALLGAILLRKLLPSANPLQN
LNNWVKLAIGSAVIPPLFGAVLAVIFTPNDENLRTFFVWVLSETIAAIALVPIGLLFKSH
YLLRHRNPRLLVETLGSLCLTLALSWLALHYLPWPFTFIIVLLMWSAIRLPRLEAFTIFL
ATVMVVSLTLTRNPEMLTAPHPSVMVNAPWLPFLLILLPANVMTMVMYAFREERKHISES
ETRFRNAMEYSSIGMALVSIDGRWLQVNKSLCQFLGYPPEKMCGMTFQQITWPEDLHDDL
EQLESLIKGDINSYSMEKRYFNHAGEVVWALMSVSVVRDNNGAPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELGPDIISWDKRMFELYDIPPHIKPTYQLWASRVV
KEDLGSVEMTINDALKARIPFKIEFRIQVSEGIRHIRALANRVINKQGDVERLLGVNMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICTDVDMNVTFMNPVAETMSGWSQEQAMGQPL
LSVLRITFGDKGPLMENIHSGDVSRTAIEQDVVLHCRNGGSYDIHYTVTPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQSVGENHQRHALVCID
LDRFKAVNDTAGHAAGDALLRELASLMLGMLRTTDILARLGGDEFGLLLPDCGIENAYTI
STRLIQAVNDYHFMWEGRLHRIGASAGITLIDASNNLASEVMSQADIACYASKNKGRGMV
TVYEPQQQHLQQQRTLLAHEEQARIINDNHMMLLARAVASPRIPESINFWILSLRLWTSE
GNVLEEASFRSGLTDPALSCALDRRVFTDFLHNHATAITLKGFGVALPLSPQGIASDETI
NEILAALSTSALPPRLLHFTLHSDVLLAEDERAKNNMIKLRNAGCRIIVSQVGRDMEIFN
QLTRQMCDYVMIEPELVTDVHTNLMDEMMVTIIQGHAQRLGLKCIAGPADQALIMDTLSG
IGIDMIWGDTIAQTQPLDMLLNQGYFAIN
>A0A0Q0NXK1|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MHFIKQNLQEETALKRYNTLLCQRHYWPFINKITSPIIKLTFCLCLILLGCFTQHVFANP
IQNQAADDIFNQFNNDELTGTLFTDEKLLELKALIAPNDLPRLQALETFTCKQVRAHETD
KLHALIKSTDSISNGHYYAKSTPILLNLCRSKALRYLGKHEQAKAINLAMLASATELNDE
NVLASAHNSIGQQALFENQFFNAIESISKSYELHQKIGHTNSANLNIIELASAYRRLGDN
DKALYYYGIAEQRLIENQSHILLAIVQHSLAYIKLDNGEYQTALAYFQDVLNVANKSNNQ
LYQTRIKVDMAAPLIKLSRLEDADRILTDAQTIIDEEMFSHYGYMHAYLFELRFLQSHNE
QALRHFIEAERSFKKYNNKKGLSLIYQLISEYFAQQQDYKTANHWHHQFLTIHLELDKAT
QETYNSEMRIRFDSKQLEDQQDQLLQFQALKEQQLEALKTKQRLQYIALMLTAVFFIILV
TFLIKLIRKSIQYKDLSLTDPLTELPNRLFAYQVLNKLLAQKNQFSILLLDVDHFKSVND
QYGHDAGDRALQLIAKQCLSILNKDYTLSRIGGEEFLIIMPSTDKTQAIRFAANINQKVK
LIDTTSLAMNKPFTASIGISSVTSSTTISAQLKQADIALYKAKNNGRDNTVHFQDCSSHE
REEQQ
>A0A2K9K029|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MTRLLFFIFTLLLPITSFAAIDDYVVKQWNIQSGLPSQSVKSVVQDNQGYIWLGTQFGLS
RFDGHQFQNFNTQNTEFLNSNAINKLVVDRFGMLWVGTRRGLLRLNPQTLEARRFDLQGP
VRDILQDEDGGIWIAANGLYYVSAKKLTLAANNIEQSTLDVTQINQIVGSVTKMALVPDG
IWLVNERHLLKISESSNRNGDGVRLELASKVSLPEQLAQTIIHDLAWVDGKLFLASELGA
YFLDIDEVLRRYQDAGNNAVYKFLNDKEGGLWVSTYGRLLYRQNNGVWQAVEPIQLDQSI
WFADIFMDKDNNIWLASLNEGLWLAHSGKVERHHIGPRVNQAISAITQGPSGQLWVASRE
GLGIMGLNDSYQPVLTSAQLNRSVIHDLEFIGEKLILGTDRGALIYENGTLQKLTERELR
QNPVFSLSPSNRGGMWFGTGRGLYRLDYKGITPFAYNAFLGSQFVTFVEDFPRYGFIGTN
KGAYRYNDKGIEKIGSQTSLDTAYITSILHLDTVTTLVGSLNDGLFYRTSDGDWYQLDAS
NGLPYGSIFSLHYDKSNQLIWVSTMKGVYRMPVAQFGHVIESLQVEQVISPFDRQLDGRP
SQCCSGLGHDAVVETESAIFYPSLQGVVEIPKNVQLFGGGDLLPRLESLSTHDRVFSTES
LNQVIQLETSERDLTINYTAIDFYAPHSIEFRYKLNGHDTQWRDAQSRREAIYTNLPPGN
FTFVLEAKRQGQDWEKAKVLSLSIVLPRRFDETIYFRLFITCAFIFMFYLIFWVFRAQER
RKQAALEALVAERTTELRKANEKLNQVNTQLKLVSHSDELTGLRSRRFLFDQLPKDVEHY
QRNAQSLQAQNKSLVLMIMNIDDFSKINDSYGPIGGDSCLQQLATLLNTRTQGSDYVVRW
SGDEFLLLLRDFSRDDIEEYVSDLCKAIAETDYRLPNGKTTKLTVSMGWSYYPLPLLGGK
VIGWESSVNLADIALHQVKQRGGDGAATITFDDQLDAFEFEQSANIESQLQLLQSNGLAE
ISVWMR
>A0A173YKD5|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKKKQTQIRQYAKIMSVFLVAVVIGLLIFFYCIQRSVEHRSQKMMMNNVSRQSVHLRTIL
NIQYAYLNGFAEEIGKSDQLLDQKNINLLQSVTKNTDFGATALIEPDGTSHYSNGQTKNV
SHRRYYREAMSGKRTLSEPLDSSISGSTRVVLGVPIYKDKKVIGILGGSYDVTALSRMLF
EDLFDGEGCSMIIAQSGEVIAFEGDTSYWNIDYRDNFYTYCKKLMIKDNVTAKMIKQDFY
KGKSNLVTADSKKKGNVRHYFAYMPMKINNWMLCYAVPEKTAQQSYDFIEHYEIIFMAVF
VILVILLVLYIVHENYRRDQELMKYAQTDALTGLYNKETTKLRTDEILSTDKDMIHAFLI
LDMDCFKQINDGYGHAVGDIVLQKFGQLLRDIFREDDIVGRIGGDEFVVVMKNIKMKEMA
IAKAEELLTKTQQYEIKELNGSAISISIGIAMAPEDGECYMDLYKRADQALYQAKRSGKA
RVCGY
>A0A7U3F3A5|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAIFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPVITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSDELMD
KMTSGEGQLYDPRSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLINIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A5Y6M658|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDYSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A747EAG1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A403F7I6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A8I1ZMR5|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp|TrEMBL
MSTIDRLSQLIFNIYEAFTVAFFIRESDHLKCLSSISFAPSFDKSRPVSIENSLPGWVIK
HNEPLIIPNFDKDVEALGYYGVDEGIKSFMGYPMEGKGVIIVDSKKKWVFTDKEKKILAS
FVSLISEEIEKRKKTQDFEDIIEELIIERKIMSLFRNLNLSHISIKEIFVELLSLSGADL
CFTGIEKNGKLFIKEILGVNDEDYLMKVCPSGHSIASTVLDGERELLLPYNSGFLKEKAL
FFSGESIKAKQFFGFPLFSNEVPIGVIGFVSISDRPLHEKSIEPLRNISILLSLYYSSLL
MRENLEKVKDFDPVTGSIQFTTFLGFVERSIKKNERFSLLSVKLGGIDMYNRNMGYEFTN
GLLQKVFQIIRHCTGSSSFISRKGGGRFYILLREREAFDVRNILKILNYTIAKNISEDIK
IDQNNLTEVGVSHFPDDSQNLWELLDRAKERRIRSA
>A0A736JTY0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHLGSVAN
VLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDKRRTLP
LYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRSGFYLS
TLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLPLD
HDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTANMLNDR
ERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALTLL
WVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYRE
ARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVL
PGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADK
RLYYAKQSGRNRICASDATQEREKK
>A0A174DEU5|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MKKLSRHELMQYGTAIISFLIVMTFTLLIFFWFVQQSVDKSVQNVIQKNTLQQKDHLELV
LEKEYEFLESPAAYFGTTSDLFSSDNLQLLAELASSSSFHRLMLFSTDGIGHSSDGKNTD
ASSRDYFQKTLEGRRVLSSPLSSSVDNETLVVLTVPVYDKDQNIIGVFGGSIDVAKLTTM
LFEDLYSGSGYSFITDSDGNIISIESTHNEIRENFFTSSSDWVFQTSEDGATLQEDFKQG
HANCRKITADLSHARYISYQPLKYNDWMLCYIVPAVEARQHFAFINNFEIILFAFFICIV
LLLIFALWKINQKNQTSLLRQAHTDALTGLLNKVYAEHTISEWLREKDFEDLQALMMIDM
DYFKQINDTYGHATGDQVLKIFAGFLKEQFRTTDIIGRVGGDEFMILMKNVRLDYSIHLH
LQKLYTNLQNVDIPELNGRKLSCSIGCAVAPTDAESFSQLYRLADHALYTAKHNGRGRFV
IYHDIKNQQETVLS
>A0A6Y0UB66|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVIA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A603L0S0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAT
>A0A378CPZ3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGDNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVITHYSQALS
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSASGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TCYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHSGGGQGAVDGGQYAVQRGSAGRSAGQEWAEKSFVS
>A0A5U2F5F8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKKSGRNRICASDATQEREKK
>A0A1V5FGP5|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MSACPAPGKAEDAELLAEIALGVRSVEAIFLPGLALRWISPSIEALTGFTAADCVAAADP
FELLVFEDDRVFCRRMAQRVAAEESAQAFELRLRARDGRAVWVQTHWRPRADGGLRLSAE
HIQARKETEFTLLETVAELRRQEALRELYLVRSNDERQRLAALLNLIRLGILFIDHDRRV
LYHNRAMLAIWGYPPDTVLVGCRDAVLKERAPVVLADPAGYLAHIHRTVRAKQSISEEYE
FRFADGRIATDRSAVVAGGEAGRRIGRLWIYEDVTVARRTSMQLVELAERDELTGLYNRR
RFHEELGRMLADAGRRGSRLGLLAFDLDGFKPINDSFGHQAGDEVLVRLARELGRTVRRN
ETLFRIGGDEFALLVPEGSTEGLCELAHRLVETVGAMRFVFEGRAARVTASVGIARFPDN
AREGEALVAAADEALYRAKSEGRNRAAVSGRRADESARMPSSNPDEPASRED
>A0A742QPK5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDSMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0K8MZT2|diguanylate cyclase|EC 2.7.7.65|Gluconobacter frateurii NBRC 101659|TrEMBL
MTVDTLPSITSSLSPDEREWQLIIDAVDPRIRLIVAKTVEERAPEGVEFFYTTLLNHPEA
SPFLSNQIVNDHLHSALLKWCLSLFSALAPDLSSLIATQRRIGLVHARIRVPLHVVMHGA
RLLKSTLRQSLFDSALSSKDLSTAINYVENMMDLAIETMSREFVRDLQKEIETDEAYRLI
TLGQDVTLEREVQRAALLDWGHKILLSICCNAPPPLPLLESSGFGLWLNHKGSLLFPNTS
GIEHIRTAIRRIDHVLVPSLALETPPAATRIHELQAQIEEIRFLMDDLFKESEALESGRD
PLTCTLNRRFLPTIMAREVAQSIRRQVPFSILMIDIDHFKTINDRYGHTGGDAVLRQVAE
KLVASCRTSDFIFRYGGEEFLVALVETDAQRAFQVAENIRENITQISTQPTGSTSSVTAS
IGVAHFEGHPDYTHLIEDADRALYYAKARGRNCTVIATPNLDSLPRY
>A0A518J189|diguanylate cyclase|EC 2.7.7.65|Rosistilla oblonga|TrEMBL
MPEPGPNENLDAFAIAKDALRLIGQFKTPPTPNVYRVWYRYVEGQDQELVRQLQPAVNDA
RSVSVGMLESLHSQSPDVVDDTNANIGEALVAELSRFQNLLSQQQAAGDEFEGTIDTASK
LLNTNSPSDKNSADCIAVINAGAALMKGQLTEASDKLAAAKNQIAKLQTELAQSRRGMMT
DHLTGIGNRRYFDAHVRQTLQSLEYCSGAVYLILMDVDHFKNINDSFGHDAGDQVIRFIA
SETSRRHPNVSLSRLGGDEFAVILQTNSSLEAAEFADELRKFFATQKLKIMPSRTPMGSI
RISMGLARLRVDDNEQSWYTRADAMLYRAKGAGRDQVAIEEECMPV
>A0A5C6E911|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MLGNTLMMAGGSGLALILFLIGIKVGMLIAASRGYRGKNGKSGSALSQKERQRVLQMLQE
LGEWTSEYSGNVSDYQTRLGKLNEEATTNLASDQSAPKVIALLQQIMESNEMLQSRLDAA
EDQLDKQTKQIESYLTEARTDGLTGLYNRRAFDNRIEDLFAAFRGGGRSFVLALIDIDHF
KSFNDTHGHQVGDHVLQEVAKTLRYELRESIMVARFGGEEFAVLMDGPLRIAAEKMNEVR
KKMAALELRSGSKTLSVTISIGVSEPRDELVIGPLIRRSDEALYAAKNIGRNRVYFHDGK
STMLVGAPEVARRQ
>A0A378YDQ2|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MKRTLLSAASLTGRLRLQNLAVVSVVAILCIGLFAMAWGAFQRASDARAALDALQATLLA
MEKASAERGPANAVLGADLPLPNESVAALRGAREVTNARLQALLSALSASRCEQCGPSLR
AVERARLDLAAASANVDLLAQRPREMRSDAAVRDAVDRMVRVIADFTPVASSRINVVSRG
APEALHFLVLARLAADLREYAGQLGSHFTATLTTGQSLSDTDQRAIERTLGRIEQLRDMI
TSRMTDTAVLGPQTLDALNTQYFGAGLRYVAAVRALAGQPHPKAPTTAEFAHTYVPMMRA
ITDFRDNMLSIARGKVDAQYSSALRRVIYTALAEAALVLVIALVLRNFRRSVVQPFEAAA
RFVDALAQGNLDVAVRDERLPKCRPQVRAVFDALRVLRLNAVELAQLRRERARLLGELEM
SADTDPLTHLMNWRAFERQAQALCATNSPGRVALIKFDIDHFTNLNATYGHALGDDVLRR
VGAVCLNTCQPGDVVARLGADAFVILARVLDESRARQFAELLRGRIEATTLTLPDGDALP
LSASFGIAMADPVTFDAEGRALGMPTNVSALLSQAERQLHAARQARRHALD
>A0A2S0XL82|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MHSAAAPTDRGNDIASSVLATMAQMGVIGLPRNYEIFYEALTGTNPALSLEVIALGNRPT
QDQLDLIGRKFFAQNHGQGIVEHARDILARELEGVASLLRNERSHLERYGKVLDETSSGL
NSRTAMSQELLQKIVGVMSVATASTIDHGKQVASTLGDKSSELESVKSKLEEYKKLADTD
PLTHIWNRRAFDRRIARIYNDNKGILFSALILADIDRFKDINDRHGHPVGDKILRIIADI
FQSSVHRDMFVARTGGEEFALIVEGTTEEATFEIADRVRLLVAQTQLKEIQPGVNCGQVT
VSMGVCMASDAESAEDLYAKADRALYRSKLIGRNRVTRYSTIAERQGKNWMLYKKD
>A0A2S0XLG2|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MLLNHLATGECVANLHTGVGNCRTMTGALLLILQAVIYFVTMAAVFRSRHQFGIGIFVCV
LGVMHFLETYLAAVFFVQLPFGLISPGSTVMFSGKLMIFLLLYIKEDAETVRQPIYGLLV
GNCLMVVLALILRLYSSVAELPGYRPNLTFLDDMGILMIWGTALLFFDSIALILIYEKLG
QRIANTLLKRIFLSAAIVLTFDQLMFFIGLHLVSGVPISALYGGWIAKMAAAALYSALLV
GYLRFIETSKPALAGPEPLLQVFDRLTFRHRYEDLLQKTGKDILTGTSDRGQFEAVAQSL
IDQALAERKPVSLLMIDIDHFKNINDQHGHVTGDNVLKDVARSLGSSLRSGDRLFRYGGE
EFVAICHDLDRADAATLAERLRANVEATTFVEPGVRATVSIGVTTADTGPVSTEQMIRDA
DARLYSAKRLGRNRVESAPVAS
>A0A290HCW4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MKETSLIYHISNLLYAFLILYMIFNATDTDNSRILWAYVYPIGTIFLFGNRLGFLYSCVL
LGMIIGLFGIVPEIHTTYSIPFQVRFSVTYMTVAFISSWVEYHRSRYQQESMKSHKALFL
EQMNLKEEIGQRIELEKELQYLAQTDTLTGLHNRRYFLEVAEQEFTRAVRYNGSICFAVL
DVDQFKNINDTLGHPIGDAVLKALAKHCLKSLRDTDIMARIGGEEFAFLLLHVNEEQARA
KMETLNKELSSLEIPYDEGKILNFTVSIGLAMYTPEIKRLDELYIKADAKLYEAKDAGRN
CVR
>A0A377FSQ0|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MGQVVNIFFINISIIYLVLSLTLYLMRHVLPVQVASPLAVRVWFGLAMGLAAVLLTVNSF
SVGEARIDLRIIPLALAAAYAGPVGVAVTIGLTLLGRFGLDGMTDQFIRSFGTLGLFFVL
SLVLNRLSLRRGHLYSAYLVFGAVLVLFRIAGNIPMHAFTNVFLPYFVITFFGGWMCYWV
AKQIETHLRMFRLHTQRATVDELTGLPNRYMTIERLNDVEASGLPWALLVIDVDRFKQLN
DTYGHRAGDAVLRRIGTTLRDHCPEAGFVGRYGGEEFVMVTEDTHDADQLAERLVRAVRE
TTYTFEGQPIPMTISVGVSIANAEPGTVVFERADAALYQAKADGRDQVKIG
>A0A1V6GZ51|diguanylate cyclase|EC 2.7.7.65|Thermotogae bacterium ADurb.Bin062|TrEMBL
MSKNEFDEFSKELIAMAQSGGLTLGDVDIDQFESINTRYGRAGGDRVLAHVEQLLKSCLP
EGFFVRRFGDEFYVYSSNCSLEAMFMELEEVRAKIAAHKVPYDGHEIEVQVSGSVGEFGR
TADNVVKLLNLCSEGLMLAKKQGRNRMVFAPGSREQKMVLKSSYYLSSQLEGLSKLSAKT
QKSESALLREAIDDLLRKYGL
>A0A0F0CB81|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MKQMIRKRLCIVILTAMLISLFVNYFQLIHNAQSGMYRNSQNKFWQIGQILNQNEKETQK
AKESLMEQCFMSAEAISYMIQGKPDIVGNQQEIQRIAGMLQVDEVHLFDTEGNLYAGSEP
RYYGLNFNSGEQMRFFLPMLKDYDLRLCQEITPNTAEQKLMQYAAVWSRDHKGIVQVGLE
PTTVLEAMKKTELSYIFSLVTSEKDETIYAIDPDNGLILGSTDDGLVNRQIQDIGIEPGH
LGVRGRGIRLMINQEDSYGVFETSGSVILGITKSTAALYGELNRSTLLLAFYLTCISLIM
IVCISAYIDRYIVDGISSIHEKLERITRGNLDTRVEVDSTPEFGELSFQINQMVESLLDT
TNKISQILEMSKAPLGVYEYNCDMRRVMATNRLAEILMIGRSEAETLFSDYTLFEAALEQ
VKKHPVEGENGVYRMEGEEVRYIRLETFARGHSTLGMIMDVTDDIREKKRIEQERDVDLL
TGLYSRRAFYRQTEALLSGSEPLGHGLMLMADADNLKQVNDQYGHQNGDRYLAAIGRILI
SCAWEKCVTARLSGDEFAMFLYGAGSREELMVPVRKMMRDMEEAGVELGTKERIPVHFSA
GYVFYPEDGCDTAVLLKQADEAMYDAKKTFKAASAHGGGEPVIYS
>A0A0N0GNL8|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MSRKAVQHQSRRVAAACPRLCYCHGEHKKSASGIITVCASKTLCLCSFLECTHDQPFQVI
PPLLPRLRNFYTDNRLALRLVAAVIVTSVLVALSLAFFLARQEYQRSLTQIRTDLETLSR
TVRPQLAVNLWLVNTEAVRTQLNSLLQTKVVGYAELVETDGSRYQAGQLPDDHRSVVSMS
FPVEYLHPLTNKAVRLGQLTLVNTLDGLESQIFDQMMRILLLLATGMFAAALCFILLYHR
LIARHLRHIADFTRHFNYESLTAPLVLARRDTSPDELQTLADAFNAMRRNLQQGLNERDQ
AQHELIREKELAEATLGSVADAIITTTADGRVKLLNPAAETLTGWMYQEALGRPITEVVA
TLAESGSTQLIEMLDEVQSGTHPARRVTATVISRLGQRYRVEMALAAVPDADGIGFVVAL
HDISEAEALTARLAYQATHDELTSLTNRRGFMSALVQANETVRSGGKACVLMQLDLDQFK
LVNDTCGHLAGDELLRQLARLLQEMVPIGVLVGRLGGDEFGVLVPGEESDGAQALAERIL
MTLEQYRFVWHDRPFTVTGSMGLVHLDADAPNLQEVISRADVACFAAKEAGRNRYSWYRG
GEVNLEHRHNELQLLATLRQAAEQNWFQLYFQPIVAANGQGEPHYEVLLRLVDATGKVIS
PGAFIPAAERYDLMATIDRWVIAHTLAEINERMARGEKVTMLSVNLSGKSLTKQTLAFVL
EQLDESKVPPDLLCFEITETSAIANIKESTLFIEALRLRGCRFALDDFGSGFSSFTYLKT
LPVDYLKIDGSLVRDVVEDHVSRQMVIAVNRIAHAMGRQTIAEYVESAQIAAKLTEIGVD
YLQGYHIGMPRPSQV
>A0A8G0G1Q3|diguanylate cyclase|EC 2.7.7.65|Devosia salina|TrEMBL
MLVQPFAPDDLPYDAVPLAGGDAASGRAFLRRLRDCAGMAGAGLVAQGLHWVEMDGMAPP
EGITPAMLGLSGRVATDAASMLIVVPIPSVYRNAPHWLVLWDSAPRPAAEANLLLARVTE
LVAHAAIERRRGAEIHRRQLIERASATARIGIWSCTLPDETLSWSDGVYDLFELPRGSLV
DRTQVLRMYTPESAARMQVLRADAIARLGDFNLDVEIITATGKHRWMRITATVDGVNGRA
RRIFGMKQNITEEKLLAERTRRLAETDSLTGLANRSLFQARLDDIHGAVTRNPVGTLLLV
DLDRFKAINDELGHSQGDACLVEAGQRLVECCPPGALVARIGGDEFAIIIDRQAKAEDIT
LCIRIVEAFRKPFHLAGQARRVGVSVGMARRDGQSADALYRNADTALYQAKSAGRDTWRQ
YSAA
>A0A1Y6KV64|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MIINIKDFFKKTLRHFKLFCFFFIISSSLYFIYNIYNINKLQGQYITTLNNLYSAARRFG
YFYNNTGTEDLKEGQYLFNGVSVVVNASTQAKILSTGINKLRLQIDKLTDNHIWTVAVFE
TSAKYSHFDPLRAVYLKLYDHVVLNSIVKNEGLMDTYQSFYGCNIKLTDIYTEQSTDKIL
RTVYFPIYNNKKLDALLAIDINNSMFKNTLDDYNRNNMTIINMNNNNLYQTQELLPCSEV
DPIHLGINFYTLLKFTFLPSILLMFLYHSLTKLIANKNFILHYDQMTHFYRRDFYETKLL
NQSNFNLLIIDIDHFKKVNDTYGHEVGDEVIRAVTKRINNCIRNNDIAIRWGGEEFMLSF
PKMNSEQLTRKAQQICDSIALYPISDIDISVSIGGVSAKNIHFNDAYKAADQALYHSKNN
GRNQVTIV
>A0A0M7PTP2|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MVASVVILGMLCVHLFCFCAMFLLISTRLGGRKMGTDVFAAGHLLLGVAYILQLLGAEPG
WGAMNFLNHTLTLCAPVAYVFGALRFFNRPIPVLYPMLALAIFYTALQVLVQAAWGTEAR
HALLAASCALLFLAMTLGLLYGARTFARDLRLEMIVFAILVGGICGLNAAKFMLILKGGM
PALDMQGQFQTVFYIYMSFLGTVLPPAVVWLILRRLTDELRTMATRDPLTGLLNRRGLMD
GLEAHFRVRHAAPSHLLIVDIDRFKQINDTYGHQTGDQVLSRVARVLQDTVRQGDLVCRL
GGEEFVVVALNSDRDGALHLAERLRAAIAHSQVPGGRPHGPIRCTATIGVSQRFASTQVL
DDIMHQADAALYRGKMSGRNRVEWAGEAMALPLAAQASA
>W5SIM5|diguanylate cyclase|EC 2.7.7.65|Borrelia crocidurae DOU|TrEMBL
MMKGIILDNFDEIAIEPQKLLLVDDTPTNLDLLLDILQNNYDIRVALNGFDALKQVEIDK
PDLILLDVLLPDVSGYEVCRRLKNDPETRDISVIFISSRNSTDAQLEGFNVGGVDYILKP
FNGRIINARIKTHLELKRLRDYFKNLSRIDGLTQIPNRRFFTDKFAKSWMQALEHQDNVI
VGMLDIDYFKKYNDNYGHTNGDECLKLIAKSLNRIAIKYKIDVARYGGEEFILFSVNKSL
EEMIKIVSFLIEDIRNLGIVHEYSDISHFVTVSIGLAEQVPQDSNFTNIIKLADDKLYEA
KISGRNQFKY
>A0A6F8ZIA5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MRWRVTTDGPPDGVMRFSSLAQALQTARSAARWPDDLAVDDIVVREAGGRPVEERHRLAE
AWDQISALFAAKGTRVLIVDTAWRPGLWAVLLGISDTLPDPSWPPGDPTTWPEPYATLAR
DRLSGCWSRPAGERWWQWRVERREPGPYAILFVDADGLKTINDTQGHAAGDRLIQRIGQL
VRSAAPASAMVSRWGGDEWMIAWRETPDATMDHVVGNLEAGAAEAGVAISCGGARCLVAS
GWETAIQEADRAMYQAKVAHHQASGRQIASTGLAEPKEEPAAAPPAEPKPPREEPAAAPP
AEPKPPREEPAAAPPAEPKPPREEPVTAPAEVDGETRPTSQEPAGQPLVAPASPAGKRRT
WAMKSATAAPSSPPAGRHAERSGSSPPPWRTGVAHRWGVTDLDAGRSTAGESHPETEPGA
TPQPPGFAWPEWAKAKRAIWASRRDEPPPEIPQVEKPPDQAEPEIPHPPTESHVARGLPI
PVGTVWWVWGEDRRVGTSTLALVLAQWLAWEGAVPVRLLEGTPTHPRLGVMIGKAPPHNR
GWEVSWIAGTPAQSPRVEVRMADRLSAWLFAESIAVHPPILDRYLALGARSAAVDAVVVL
DAGVRPPALPGVEGICVLAGARPVVPLPSGVWAATRSRVDPATPRLIRIPSDPLGLGGVP
TGEWVRALAPLREAILATWREGAAASS
>A0A6F8ZD49|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MAGARRWNRKGGRPSSLFRFLWTRALLVLMLGMAGLGLFLWAQARAAVIAAAGQRLQARA
AWVARAWSRGPRTEAAFEADAAPWRVLAGWALLGGSRETVIAHYAVIGSDGRVLAATLPD
LIGQPVLALPPDLLARSPAGWEVAVTPRLRTESVVAWQAVGPGLTAVGSLPVGRLLSAAL
FSLAWRLALGGAALAAVLAWAEAVLARDLRRGLDWAASPGEPGPAPVPLSDLLGARRRVR
QQLDALADAARRDPLTGLFNRGGLEQVLESYFALPQPPPAVFILADLDRFKQLNDTRGHA
AGDEALMRVARNLAAGVKAEDVVARLGGDEFVVVLFGIRCNPRVKNRITAVLSRVASLES
ELGVSAGVVDLPAEAGTFAAAYRLADRRLYAAKGAGRHRWIGPHTGVVEIPTGPPPAL
>A0A5P9B6B5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MIRLLSLFLIIFISLPAKSEIDRKDAGIQIHLGETPNSDWNVLYLSTLNTDPDRAFNMLK
ARYASAESNGEKLYISALLYTYMKRHNQPFYGGSSGDENYQALEAKFIEALFLDSQGQYQ
TAQQGFIQLLRQMKAQSDETGKLLLKYQLCRSFNEQSRYHQANYYCSILEADINDIADPI
VPKSIAYRVIANNQYFRSDYQAALNTYMTLIESFPKGQDISGIYNDLGNLFKEMKQFDQS
EQYLKAALNLRLTASDLMKAQVRHSLAKLYMAQSSYDLAISQFLQAKTLLYSSGHNYGTA
MTTLGLGKAYTATQQYPLARAYLTESLSLATELNNDVMRIQAYLAISEMFEEQELLSEAF
DYAERALILARQVERESYIADVYQQLSKLYRTQEDYQQALFYYEQYAQSQIATRNTDNRL
ALEALSLAHNQYEQELESSQLRNQHDLNQLQIEKMQQQKLMYNAIVLLLVVTASLTFYSN
KKIRRKASIDSMTKAYSRAEIIKRVKETKASSKANKQHVLVLLDLDRFKTINDQFGHPTG
DRALVHVSHQIVKHLNKGELLGRLGGEEFLILLKDTNIEDVRERVEEIHYAISTSEFLSE
SKKPLTITASFAYLATQKSLSDFDILYSVLDQALYQAKANGRNCIIDAYNDPIAADSFSD
SPIAYEPVQP
>A0A2H6A2V2|diguanylate cyclase|EC 2.7.7.65|bacterium HR33|TrEMBL
MRFWIDPQKCVSCLACVRVCPAEAVAVDGDSVSIVEEACIRCGMCVPACPHDAIDASGEL
AKAVGYAAGGRAVLILSVEAAAYFYPSTPEQVVNAAFKAGFRAVHHGVTGDELVAAEYLK
LWAEPEWGTMIRSTCPVVVETIKREYPELLPYLAPVETPVAAEARYLRRLYGRDVPIVYA
GVCLADGEADVDAVVTFQELAQLFEARGVVVSEQPLYFDRVVGERRRHWSTAGGMPLPVL
QEEHQASRRFRKVRGLGGLAALARAVAVDRIDLGFVDILPCEGCLDHPLLGPREELFWRR
RVVGEAEPPRSRVPVLEDGVGLEVGRGFEPGRNGRRVPESDVEAVIEAIGRAPTGKPWDC
GACGYGTCAAFAEALVKGRATYRQCPPYQERRLAEAAREAAVDRLTGLATFRVFKDRLVQ
EVARSKRSGEPFAVVFVDLDRFKRLNDTYGHEAGNRVLEGVGRELHRAIRSTDVAARYGG
DEFVLILVRTDEVGGRRVGEVVRRSVESMGVAMGYGEGVVTVSVGVAGYDPGRPEVDVVE
EADRALYRAKAAGGNRVE
>A0A4Q8U670|diguanylate cyclase|EC 2.7.7.65|Alteromonas sp. KUL42|TrEMBL
MKTITNQALEPVINNIDKAIQSHRFWVRSIMHTLVCDEEPSSKDLSESAHKLCEFGCWYY
GPQPEKLERLQAYAVIETHHINLHVATAELLRKKISNVVISQEDLDVFFGHIDLFLNTLE
QFRREVYTLLYNRDPLTGVFNRRSFDEELNKLQDLVSKDANLACIVILDLDYFKKINDSF
GHTKGDEVLRQTAEVVQQKLRNIDKVFRYGGEEFVISLLHTSKAEAYQVAERIRESIASM
NIVFEGNSVNVTASFGIAEVASNINAEQAVVLADKALYQAKKNGRNRVEIFEC
>W6MCI4|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MKYAFSLAMLYAVVSTLWIFGSDQLVFWLNLDAEATLHLQTAKDWAFVIASSLALFFLLR
RLDAEKQLAAQLQMPPRTASMPMALLVLFAVLAVLPGLLAYREVLRHFGDTAVSVRLLVW
FGFVLLFALIAGSVCILFWWRNTQAHFLLDCLRVDFERANLSSRHEALLRQSWDVVVLLS
EDGTIIEVNDRVFEYYGRTPEELRGRPVIELRFASSKEALAEDYQRVAATGGAIFERLHQ
RRDGTPFPVEVSARAITDQQKLYFQSVVRDISERKRTEAALADQALRFRATFEQAAVGMA
QVAPDGRWLRVNDRLCAMIGYAREELLQKTFQELTHPDDLSKDLWLVEQILSEQIRTYSM
EKRYFHRDGTTVWVNLTVSLLRGAKGQPEYFIVVIDDITTRKRTEHRLARISRFYAALNA
TNEAILHNTGTADALFEQICRIAVKCGELEGAWIELVDPATQQLRPQAAFGELRSRLPSR
GESITEGVALPTQPAHTVVSSGARWLNNDLLNDHGGEPDWQFLVATTGVRACAAFPLRRA
DAVIGAFSLYASEPDFFDPELVKLLDQMAADVSFALDNLESEAQRRRAEQDLRLAAAVYE
QSGEGILVSDRNNAVIMVNRAFTAVTGYCLEEMRGRNPRTLSSGRHDRDFYRSMWADLQE
TGRWQGKIWNRRKNGEIYPEWLGITALRDANQRISHYIAIFDDISAHRATAQNIRYPVGR
DPLTGLPDSTLLRDRLRQALLHAMRHQHSVVVLRLDLDRFAAVNEQYGYTVGDRLLERVG
SRLLALVSETDTVCRLTGDEFVLVLTELDDPQEIGRLADRIRQVLAEPIELDGQTLISGA
GIGISRCPVDGTDVDLLLENAAQALRWAKDCGSNQVRFFTADSHQSLLPEAKRSC
>W6MBT6|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MNATPTELVNLQTERLQSRVRHLAEEKAYLQLIMRLIEQLNPRPGLPDMIRNMLHSIMEA
LGGTDIKLWYWIEHEVRHASFLGESGFVAEINDPLAVQVVSQRVFIERRGTPGQTLLRDG
GTPDSWTWCFPLLVEPDLIGVIKLENIYLSSRPLRNYLPIFFSHAALLLSNEIRNYLRQR
AQAALREKTEELNNYFNGALDLFCIADTDGYFHKLNPAWEEILGYQVADLEGKRFLDLVH
PEDLAATLGTLATLAAQQPVLNFVNRYRHRNGAWRWIEWRSQAKGPLIFAAARDITEKKF
AEDALRLAASVFANSQEGIVITDNTNRILDVNAAFCRITGYAREEALGRNPKLLGSGRQD
AAFYETMWHAIREKGAWRGEIWDRRKSGEIYPEMLSIAAVPNEKGTIEHYVGTFFDISHI
KAHEAELERIAHYDTLTGLPNRRLLADRLQQQLAHARRSGHSLAICYLDLDGFKPVNDRL
GHEAGDQLLIEIGQRLKSALRVGDTVARLGGDEFVLLLCDLALEEECVPVLERVLAAIAM
PLYLQGQQVAVSASIGVTLFPRDDANPDFLMRHADHAMYQAKGAGKGRFHLFGPTDSEPA
ES
>A0A0V9J705|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. 50677481|TrEMBL
MENWGWLKMLARRFGPGHVVNLCFLIVMIFSTLLTWREVVVLEEAYISSQRNHLENVANG
LDKQLQYNVDKLLFLRNGMQEALAMPLDFPALRDAVSRFEQQRDSRFWQLELDKRRTLPL
NGVSDSFVNQTHILSRDSDTLDNELTAALEVGYLLRLAQTRSSLTQQAMYVSRAGFYVST
QPSALSSEITARYYDYVIQPWFKEQSQRQNRMRGVRWYTGQTAQLRDELQRVTVSVPLDN
GQYWYGVLAMTIPVSSVERFMEDAIDKDVEGEYQLYDSKLKMLAASTPALRNINTFDARE
QATLAHEIEQDTEGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVQGDFGSISIALALLW
ALFTSMLIISWIVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARQLVQRCRAQ
KQSLSVIQIDLDHFKSINDRFGHQAGDRVLAHAASLISGTLRANDVAGRVGGEEFCVVLP
DTTLAQAERIAERIRLRLNEKELLIAKSTTLRISASLGVSGTQETHEYDFEQLQSLADRR
LYLAKQAGRNRVCASERG
>A0A554XHP9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MTPSDFAGVGYGLAAVLAIVCGGLMWRLRATRRLLREEQRWVSQLFDQLGIAHWRRNLDT
QELWWSDVFRRMHGVGPDEPAERARSLRQLVPEDRARINQMLEDAYARGGGEAGYRIQHP
DGRITHHMLRIAVTREPASGQRLAYGVNIDITERVQLQNALRERSAYLEAIVHHLPMGLS
VLDRALKLRVWNPQFGQVLDLPPELLYEGVDFDDLIRVPATRGEYGPGDPQQLVAERRAL
ALQFRPHRLERTRPNGRTHLVIGEPIVRDGEVVGFVTTYTDITEQKVERERLAQALDILR
TLVANIPVGVSMVDGALRLQVWNERLLELLELPRALFEQPGVTLVDILRFNIERGEYGPT
DDPEGMLEEMRSRALRFEPHEFERVRPNGRVLHIRGQPLATGGFVTVYADVTERHQARAA
MERLANTDALTGLINRHALPWALQQALAAATRDARPLALLFIDLDRFKTVNDSLGHEAGD
AVLVETARRLRERLRSSDVVARIGGDEFVVALTGLRSEEEAARVAL
>A0A509BLN2|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 3046|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPGLHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
ELEQRLQRLVNAGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A0W0W106|diguanylate cyclase|EC 2.7.7.65|Legionella lansingensis|TrEMBL
MDKLNHLLIVDDNIEDQVAYKRYISKTFQQQLSIQTMEKGELALDFLKTNQVDCILLDYQ
LPDMTGLDFLRKLKDGDVISTPVIMLTGTGNEKIAIEALKIGAYDYLNKGELKPEILYSA
IANAVEKSQLIRKVKAKESEINYLAYHDFLTGIPNRAQFETHLKKVFARAQRYCRAFALL
LIDLDRFKLINDNYGHETGDSLLKQVARRFQQCLRESDILARLGGDEFAVLADHIEHHEQ
IAVIAKKLIDALSVPLNINGHKIKTSPSIGIAIYRDSNTTISRMLSNADLALYKAKNSGR
NTFRCFSEELTIQSNQQMETENALYDALETQNFYLCYQPIIHIETNQLLGMEVLLRSDHP
VLQHTPVNTLIEIANKTGLIIPLGNWILEKTFQQLSTWREIKVSPFKLSINLSINQLAHG
NWLQTFQSLINKYHIDPRELIFELAESDMVFNVNDIGEQLATLTTMGCDLLIDNFGAGYS
SLNLIRQLPITGVKLDRSFIKNLATTPNDAKMIKAIHLLIRSLDMLFIVTGIETQVQFNI
LKNHSHLLGQGFYFSKPLRDPLPFLK
>A0A6V8LNV7|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MNAAGVSCGPFDAMDFLPMGILVLEEDFTVSFWNACLESWTGLSREEVLGRDARQLFPQL
GRPLVTSRIRELFRGAPPAVFSYHLHNHLLPARLPDGSLRLQHSVAYGVPSCEAQVRHVV
LSLQDVTEIHNRLQENLRVKLSLEQEVKRRKRVEAKLRELVTQDILTGIANRRAFLHTLH
REVRRCRRHGHALSVAVLDLDHFKAINDHWGHLAGDDALKTFVRACSDELRGADTFGRLG
GEEFGLILPETDMDGAQVLAGRILERVRAISITWPGGTIRFTVSLGLAELAPEDTLETLF
LRADQAMYQAKAKGRDRVERA
>A0A7X4JXM0|diguanylate cyclase|EC 2.7.7.65|Halomonas alkaliantarctica|TrEMBL
MRYKDRQQLGDEWQTLLQRTSTPARQAVAALVETHQESFATHFYQVMLDDTTASLFLSND
QVKQRLNPSMQRWLGAMFSVEHDDFEALVEQQEKIGQVHARIDIPVNLVLNGARQLKLAF
YRQINRDMDAAMRGDASVYVSDHIDMAMEIMSHAYSVANDRNARTEEAYRLFSLTQSVGD
ERERQRSALLNWENTLMYAVAAQQNADSLPPLASSEFGLWYLHKACHAFEGAPEITTINQ
RIEQIDNQWLDKLHSAKSASRLKALSDIRDATRSILLLLDNMLERASGLEAGRDSLTSLL
NRKFLPVVLNREIEMGRRANKRFALLMVDIDHFKAFNDNHGHDAGDSVLQQVASLLDAAT
RGGDYVFRMGGEEFLLVLVDTDPEGSRLFAERLRRTIAHEPMLVAGDTLLNVTISVGVTL
HDGHPDYQRSLQRADQALYQAKHNGRNCVVVQ
>A0A840HKJ5|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. ERR14|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDID
GFEVCRRLKSDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRPSSYERLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQASTRGKPLALMILDIDFFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>A0A4P1JXM6|diguanylate cyclase|EC 2.7.7.65|Brevundimonas vancanneytii|TrEMBL
MNPLADQTIAPVSEDELHAELARLRAEVAGLIQRAERAEALADHDVLTPALNRRGFMTVL
ARNLAYCRRHGVEAALLYLDLDGFKGINDGLGHAAGDAALIAVAELLLANVRESDAVGRM
GGDEFTVLLMNAGAEEGREKARRLSEALQSEGFIWDETRLALGGSFGVRAYAEQADAEVW
LSEADAAMWLRKKARPEATR
>A0A2S2E6U6|diguanylate cyclase|EC 2.7.7.65|Saliniradius amylolyticus|TrEMBL
MRSISQFRRNFTLLFLLLSLIVSALAYFAISSMVGTQSRQQQKAIAPVFNLIDHKLLRPL
HITHALSESNVFLPYLDSAKPDEAAIQRELQRLQTSLKVNVFIASDKAMRQYFANDEENR
ALTEQTTAWYFRFKESEADVQVVLGNQERLSLYLDYKEYNHKGEFVGVSGAALSLESFMQ
EFERYQQQYGYDFYFIDEQNNVLLTSDSGSQPKLAERTGLDQLTWYRQLSSAPLIKGVYS
NLVDYKGKEHLVLELPLPQLKWRVFILLPFDEQARSSAVNLWRLGILIFLVVVVLCLVIL
FFTERYSSHYEKRLFTDGMTGIANRRYIERLTQDLIEQKIPVSLILVDIDHFKSVNDNYG
HNAGDKVIKTLGGVLKDAMRDQDVAARWGGEEFVLLLPKTSYAQSMKVAERLRKQVAETE
FNIADGQSVRVTASFGVTQADYYESLADLVHLADRALYSAKHKGRNRVEGHC
>A0A2K8R869|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. M56|TrEMBL
METESEPYIRLATLRQLHQVVADLNTARSFADTLQAVADGVITGLGFELSAVNLVRQDGD
LVVAAVGGSAGAEALMAGRVGPRCSWERRLSMGDRWGDLRFIPYSEGWVLDDDDVPQWHT
PGPAPRFPDEWHPMDRLFAPLYAGGASGGELIGVLSVDKPRNGRRPGAWGREALQMYAFH
AAVAIGNARLRGNMQRALLRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLL
RTNDALCRLLGRPASAMRRFSFSDLVHPEDIGTLLRTSAEGGRAELRLARRDGSYVWVSL
RNSVVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLAARLCA
TPPRPGGGYEDEADSSGDGGAGGVYVDAAGHLHGFDEFEFFGTPPPVESAPFDGHVHTIP
PNEDSSVDDGHKGLAVLFCDLDGFKSINDRFGHHAGDAVLIEVARRLTNGVREGDTVARL
GGDEFVVLADGLGRADAQDLAVRLRNAITPPIRVDGRAVRVGASFGIGWAGCGMSAEEVL
HSADQRMYIEKRSRSKERRRAG
>A0A6V8LUU1|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MNFKEHIEQGADSEYLARLFDIERYAWMTLCYDMAMVIGIDGSILTTNSIWERSTGHSQK
DLNSKHLLEFMDYEDRELVLARFQRLITSAKGATTFAFRFRCSDDRYKRLNWNIYYSPEL
EIIYCVVKDISDVKDFSHAAYHDTLTGLSNRLFLLDNLPKLIEDAGRQDQPLALFLIDLD
GFKSVNDSMGHQAGDYLLQIASERLRLIVSDQDYCVRLGGDEFILLEKNCGTNGAERLAK
MIITSINKPVLIDESDVQVGASIGIAIAPHDANAPRELMRLADTAMYEAKRGGKNRCVFA
NELPSPGRG
>A0A8I1KBQ8|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWSFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGVMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGIALTLLSALVTLPLAGKVVIFNPDPIEWSLTLPVLMLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIVAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLEKLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
GRTEVAA
>A0A653IVQ6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MRFYKATQFLFPRSFELRLLTICFLAVHVPLIACIAFSAATWHWQADTLLVILLATLLGT
AGGVAAIHALLAPLTAATGMLRSIQKGERVDEIPVGGEDLVGRLLRGVTQAANDAADRSE
ELTIVAEHDSLTKILNRRGFLRAAERALVGDRPAVLALIDLDHFKTINDHLGHAAGDELL
HAFAQRMSTVIRQSDICARWGGEEFAVLLPGANLSQAHDAIERLRSSISRHPLPGVGLTF
SCGLAATAGSAELDDTARRADKALYSAKHHGRNRIEAAE
>A0A376FJY5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MDFTLNTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTGNVVNHFDERETAQIAQAIE
HATGAGSASEAVLSAGERLDHFDGVVLRIHTLHEGVQDDFGSISIVLALLWALFTAMLLI
SWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLAETCRQQSLPFSVIQI
DLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEEFCVVLPGIGLEEARS
VADRIRCRINSKEILVKKSTTLRISASLGVSSADKAGNYEFEQLQSVADVRLYQAKQSGR
NRVVWRD
>A0A653IVV7|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MRSEVTSTFLQQSLPHRYLWPVLLLIGTCLASLLALLTVTTRAQDDLQRIREQQSIERAL
RTAGEMTTHDLQDYAKWDDAVRHITQHFDANWMADNVVAYLADTQGYSHVVVLDGNDQLT
FVQTPRRADPASKLVTSVEFRRSIKRVRGLPVDGKPIVSGFSRVGSVVYIYAVAQIVPLT
PKVHLSPGSTHLLAIARPIDQAFLSGLSENQHVRELSLSLRSTSAGARAAIPGSDGKPQA
WLTWQPGRPGGELRRRILPVFLLVGALTLAAGALIVRLGARTIKALQLSETHARYLALHD
PLTGLPNRRALMEQIESRVGEDVTLTLLWHDLDGFKDVNDVYGHGAGDAVLRQVQERLTA
ALPGVFVARVGGDEFAALLTQDNIQDAELASQAVLDAFALPFLIGSYRIRIGVSIGCAGA
EETDLPANELLRRADAAMYAAKAQGKGCCRTFQSSMDQVHRLRISMEKDLGEAIAAGGIE
VVYQPIVDASTGKIVCIEALSRWSHPKHGIVSPDVFIPLAEQVGMIDALGRHVLRQACQA
AAALPVVLSVNLSPAQFWDRSLVGDIRAILEDANFPPDRLQVEITESYLLRQPEAAAAIL
TQLRTLGIKVALDDFGTGFASIGYLRQLPLDHLKIDKQFIAPLATAGQGFELVSAISSLA
ASIGLAITAEGVETHEQAALARLAGCTQLQGWLFGRPMPISQVSELLREDVQAQRHRAA
>A0A7W6UQJ3|diguanylate cyclase|EC 2.7.7.65|Rhizobium esperanzae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPTDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLSRAGEGRADETAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKHVNDTYGHDGGDEVLREFSNRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAIENAPFMLKHAGEALNVTASFGI
ASRITSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A7Z2FN63|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVSGMLVTHF
LPGGWWLLLVGWAFVWPHFAWQLSCRATSPHQQETFNLKVDAIIAGLWIGVMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPLVGKVAVFNPDPVEWGLTLPVLVFY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIIAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLENLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
GRTEVAA
>A0A7Y2LE52|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrae|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLDTLNAWLLESFSVGINKRYIEAVQKQHMVGHVHARVGIPSWLIMRGVCEIERK
VFELMAQNPQHDMITTCSYIVQIMGFSTEIMCRSYEAKTAVNQEIKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGNAGFHHPILSKSEFGLWFIHKASYAFTGSDQVQLIID
RIYQVDQLNTAVIQCTQKDELLALIQQVRDLNREIQLLVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIISREITFSRQNGTPLSLLAIDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDVKRALNIAESIRKYVENGMITSSQGQQFRFTVSIGCVL
YNGHPDYQKFLDTADTALYAAKNSGRNRVYLAKNELQVAVANTAESVQR
>A0A4P7NXK7|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MIHISTIKEMVRISPLDKLEVEKHYSYLLEQEPQFEQSVAQWIEAYQLHALTPELLLAND
YYQKLIHGVYQNSFYNVQYHQALYWLKSGLTQNQILLLFAHMRMQFIMYAEGLESDALAS
SLCHVLDVGQSIVATIFTVAESIERMKARSSQEIRRLKNSYRLVAFDLPKDVLQAYIDHQ
TWKISAFELSLGYETNIHGFETSHLKCCLAKWLDNGGLELIPKSKRRKFLNAHEQVHRLG
TMAIEESNHNRPENIVELLFEMEVASEDVMEVLLNLIEQEFVAAANADSLTGFPNRRAFD
LEFDKALAFAKRHDFWLDLVIVDVDFFKAVNDEHGHVVGDAVLKRVAEILDHVARTEDML
FRWGGEEFVIITLDKDSEGSEMLAERIRKAVEEEVFFAGTEQEMHLTVSCGALSYWAGLS
LSEEEVFELADKQLYLAKENGRNQVCHQVYDVIPIQKP
>A0A4P7P020|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MAFLKHYTWLLGLTAFAVWQMPNILTWPLSTQKLLPWLPYVIAGLGVFVGIFLNRLQPIL
ILLSLVCFNIGMQYFIPAGSTGLSAVTLFPVLAILLPLNLLLWLLFPERGIHDKFYTLFQ
LSLLVGQVYLVYWVMENLPLTYWQWISQNIGIDGLNLSKAALITMVSVWLILMLRNALLN
QPKVLDRTVVFVLFLMGFGLNAFYQFGSIAWVSSFAATMLLLSLIFDAHHIAYTDQLTGL
NGRRALLESFLGLGRKYSIAMMDIDHFKSFNDTYGHDVGDAVLRTVAYELSLISTGQVYR
YGGEEFTIVFKGKQAQQVKPALEVVRQAIENRVLEVEKQGQPVETKVTVSFGLAERNDQF
KKPEEVMKAADEALYKAKKAGRNRIVVEGESPKAVSKTTRPGRKSVKKKEA
>A0A3U2TWY7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NDQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y3XJQ0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVADALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3S4J1A7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSFIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C6YUY9|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MHYFVRNKHSQMKLLAIEGRFNIHQEKGLSDTPAVPQCSRRFTPQRIINICFFAVFIFTS
LLFWRQGQVLNNGYQASQLNRLENVSAQLGSRMQFRLDNLLFLRNYMRYMLSQPIMPEQK
RLLEAEMATLRVQDIWQTGHAHSASPPINGIGDSQIGLLPSSDRPNNDLWLTELNAAMRL
KALLPLTNLNQALQPRIYYISRSGFYLSSTPPRDKSLISGLYTHMLARPYFPMTAPEANP
HRKAFWSRMFDNQQDGMLISATAPVDYGDRWWGILGMDFSIKRLNYYLQAALPSHPHSVF
MLYDSHFEPITSSDKSWYRGKYFSEAQRLSLQQAVLKQSEGTTRIGTSFVTFTRMENPNI
TLISLQSLRQGLQDQYGRISLTLVALWCLFVITLIGTHYVISRLVRNMETLQNQLSWRAE
HDPLTELLNRRGFFDKAEEITRRGQCYGRSMAIIQVDLDKFKNINDVYGHHVGDLALKHA
ADTMTSMLRKQDIIGRIGGEEFCIMLPNTVLSEAVAIAERIHAQFNRQNLALSDGRTVEV
TASMGVSACSGTTGCSIESLQSQADKRLYKAKTAGRNQVCASDMDA
>A0A509DSZ9|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MDWHYVPESGSLDFGTNGREIIVNSTAQQLHHDAVRFSDTDALRYAFELSTKVISSVDYH
AMTHCLLSMIEEFPGVKHASSYEVFNHKAKNITGLTHQDELLFRRFPLSLEEEYEDEYTD
VLARMLSENNTGISLLRTEKSHYILLDIVKDVNPPRAILIEGELDEYHFTILEGLFSVYA
SQTALLDKKERDVLTHLLNRQSLNHVFTQILDYYRKPENEFDTNNCSWLAVLDIDHFKSI
NDNYGHLFGDEVLIHFANIMKEQFRFSDFIFRFGGEEFLVILNQTNAAGAQATLERFRKA
VEKHQFPSGKVTVSVGYSFLDPNGSMSQLLEEADRAVYFAKESGRNQVVNYLDAKEGLQS
HDSQDIELF
>A0A6Y5CQK1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDANQEREKK
>A0A8E7UXT2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Corvallis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6N3E278|diguanylate cyclase|EC 2.7.7.65|Ruminococcus gnavus|TrEMBL
MKKGMLKGQRRKLLFTVIFIMILTVSLNMIAFIWFQLRVYHMTFQQEFVYVKEIQELSVR
FFVTIVTGLILLAGMICSELYQVYKMTEEKHRRLEALNGVFQLTLQKTKDIPFEVDMKQK
RILLYGDMENECEKHYSLDRIHPSEMVKAGYICEEGLTQYEKLYFSIMEEKECEPVVLPV
QYGGKRGWIRSRTIINGKEKNKKIIGVLENYDEQKEKEAEIEHHLKNINKIQKASQRDFL
TGVYNREGLIQNIEKALKEDKNKQGVDAFFILDLDHFKEINDFLGHGTGDQVLQNTAKIL
DQCFRKEDIVGRLGGDEFVLLIRRINRIEAVHRMAKRLNESLCNTYEKDGQRIQISASIG
IALGQAETESFEKLYEKADEALYEVKREQKNGYKIYEGQSRV
>A0A0U5IRK0|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MLDPKGASAKAPNGSAVQTLGTLIKVVIVAILVSLTLTVLILLHAGSIQDETAAEASLRQ
VEGLLLMTGRNLADHVRDYAVWDDAIERVILARDADWWDSNPGRYALSTFDLSLTLAADG
ADRIYFISTPDGTRSAPSDLALEPSTKALLDLERRSSPSALRPATAGLIELNGTVYLAAA
SRFLHEEDFAPPAEALGAVMLFAVALDDTVLPELGDIMGSSPLARNTTPESAAVRMPLAF
ADGTSAGILTWTPPAPGRSMIKSVLPIAILAFASVAGLTLLFAFRARTLARRLSDDEAAR
HELAQRYESILETAGDGIFGIDRDGRIQFVNAAAASMLGLPRTEIEGQDAIHFLLCRPVD
EPAERADEAPLLRALASGRAEVSDTECFRGADGRRFPIEYAVTPMLLGNTPTGAVVVFRD
ITKRRQTEEEMVYRANFDAVTGLPNRNLLLERLGQELKRARREATRVGILFIDLDDFKRV
NDSLGHDAGDLLLRQVAERLQHSMRETDTVARFAGDELVVVVAPVADLSFLQTVAEKLLQ
VLREPFAIGTESVRIGGSIGIAIFPDHGEDPQALLNRADLAMYQAKADGRGIYRFAAKA
>A0A6G4MLY2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWASINITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVCVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLIHGEINTYTLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSARSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDTDMVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A8G7VHP9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISC
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376ZW19|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESTIKRHFDPTHVIWTQA
>A0A3P5DPM8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A8F8YXG1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGNVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376KU83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLG
SSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVK
FLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPL
SVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGR
>A0A765T601|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVHSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A4T4XSP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYNVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDDELCTNVQGNLMDEMLITIIQGHAQRLGMKTIVGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H1SBU1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLLEDAYISSQRNH
LENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELN
RRRTLPVNGVSDALVSKGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSR
AGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVT
VSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTG
NIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSIS
IALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPL
AKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGE
EFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQL
QSLADRRLYLAKQAGRNRVCASDNA
>A0A368IL57|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDCSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A827K171|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISTINNYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSLDAPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8G9LZ95|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALSAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A6D0DBC7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
VKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTILKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRQVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A376LN04|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLADVDLYYPGASLGI
VKVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALDS
>A0A8G9BQH4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A376UA13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRN
>A0A789RD85|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSAKLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8E6NI77|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000542|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A376JI56|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLADVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALDS
>A0A827BN93|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKDDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377BIA0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGI
>A0A418TWH0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEFIIVLTEAS
ENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAK
RRGRNRVELWKASL
>A0A400AH23|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X7GCN2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWMVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2X3JXF3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTSALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAIHT
F
>A0A377DIM5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNDHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWGGVMGVNV
LPSTAMLMIMCLNLMGAGGPPSVCRGSGVDGGFLPCHPRTDGHHRVVQ
>A0A2X1IRU9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLSI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A376PY48|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMF
SLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAAL
VAVISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLD
DLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQI
PVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVE
RLKMLADERLYKSKKNGRAQISWQ
>A0A3S0XJB1|diguanylate cyclase|EC 2.7.7.65|Azospirillum doebereinerae|TrEMBL
MSETTSSTLPAVDMLGVVLDEHLRWIGQWHRAAFFRDGQGGERASAPASFAAWCGAASRD
DLVHQPAVQKLASLHEQMHRQARLVLLKASGGDTPSEAEYESVIARFEEFTLHLRRLERA
FGAAASGLDPLTGLRTRRGMLEALEREHNRYSRTGQTFCLALADIDKFKGINDTYGHDIG
DRVLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETDMAEGFAVIERLRIDLMESPVPLP
DGRLVPVTASFGLVEVRAGLSIDELIVCADRALYQAKHSGRNRVIRHGVDRPVPLPTDSA
GVKPSRPQRA
>A0A376HH81|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVPPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQQLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A377FDR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPISANLRVEPSEECDASVPR
>A0A2I6JES1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A509EJR1|diguanylate cyclase|EC 2.7.7.65|Methylobacterium symbioticum|TrEMBL
MSHGHHADRDRSFALAQRAQELMRDYGPSATPRAYAVWYTYVAGEQPLLNDAIKRIITQN
RGLTEHDTDELHDQYLGGRRLTSVAGETSATMLAEIETVMEMLDLSVGSAAQYSESLRVL
SQDLSLSTLNRARLREIVGSLVATTREVAASNQVLEARMRESRAEIETLREKLEETRLES
LTDTLTGLSNRKHFEEMLAKAIEASNQRAQPSSLVVLDIDFFKRFNDLYGHLTGDQVLRL
VAIVMREHVSKDATLARFGGEEFSIVLPGVDRAAAREIAERVRVSVMGRELIKRSTGESL
GKVTISVGVAAFRPEDTSVSMLERADQCMFAAKRAGRNRTIDDSAAPETLQDVA
>A0A376HIV8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKGEETALSCRLVLREQTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFIVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X5E994|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAYQHMHNCGRELMLAIVENHWQDAHFDAFQEGGLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A109CEA9|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
METTVQNIGDYFSKTIVDSLSVGVVVLDLSSRVVVWNSFMSKHSGIGAEDAVGKDLFDIF
PYLSRNWLELKFQSLRILKSYSFVSWKQRPYLFRFQHNRQITGGGEYMYQDCTFIPILDT
DGKTTLICMTIQDMTEAAESQKIVEEVIDANKALQLMTNYDALTSVYNRGYIEKQLEAEF
NKSKMNGNVFSMLMFDLDHFKKVNDTYGHLAGDDVLKTVSKKVGGLLRNAVDSLGRYGGE
EFIIILTETNEETAAVIAEQIREGVEQMTISSGDYTIKATLSMGVVEYRADLRDYLQMLH
EVDIALYNSKKQGRNRVTKYTQLNNIN
>A0A1S7LI19|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MDKAKRAKALAKMQAARRKYAEQLPDKITQMEQVWAELCQHGWDEESLRTFHRMVHTLAG
SGATFGLAEVGAQARELELMLKSQLDGKSSLDSEQQQTITVAMAELRRIVTCSLEQGQER
YAELAASASLGHAMVNSGVIYLVEDDEQLAEELASQITHYGYRVELFITLAAFNDALERR
RPDAVIMDIQMPDGDGAEALLPIQAAQEVAIPVLFMTVHNDLVARLKAVAAGGRAYYTKP
VIITELIDTLDELVGGDEEEPYRILIVDDSRSLALQYALFLQKAGMATEVVTDPMALMAP
LEEFRPDLILMDLYMPGCSGFDLAKVIRQRAQFVSVPIVFLSGESDLDKQLAALSLGGDD
FLTKPIKANHLVLSVTSRAKRSRILREYMIRDGLTGLYNHTQTEVQLEVEVERARRRDMP
LTFAMVDIDKFKNVNDTYGHPVGDRVIKSLSRLLKQRLRKTDFIGRFGGEEFAIILPETD
IEVAASILNQLRIAFSELQHQSKETSFQVTFSCGGAVYPASLDGTSLKHAADEALYAAKR
GGRNQVVMASGQHINP
>A0A5E4UMS0|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MKRTFLSTVSLTGRLRWLNLAVVCVVVVLCSSLLAWTWGTYQRASDASLALEALRATLLA
MEKASAERGPANAVLGADLPLPDASVIALRNAREATNARLQELLSALSADRCDACGSSLR
IVERARLDLAAASANVDLLVQRPRDMRGDAAVRDAVDRMIRVIPEFTSVASSRIDVISRG
APDALHYVVLARLAADLREFAGQLGSRFTAALTTGKPLAEVDQRAIERTLGRVEQLHDMI
AARMIDPPELSPETLDTLNTQYFGAGLHYVATVRTLASQPQPVAPTTAEFAREYVPTMRA
ITDFRDNMLTLAQRKVDARAALALKWLIVTAIAALMLVLGMIVVLRRFRLSVVQPLEAAT
RFVETLAQGNLDQAVPGDDMPTQRPQVRAVFDALRVLRLNGLELGQLRRDRTRLLGELEM
SGDTDPLTQLMNWRAFERQAQALCAMPSPGWVALIKLDIDNFTQINATWGHGVGDDVLRR
VGAVCLNTCQPGDVVARLGADAFAIVARVLAPSRAQQFAELMRGRIEATALTLPNGEVVP
LTASVGIAIADPATSGPPPVSSGGPANVSALLSQAERQLDAARRARRRAIE
>A0A1S7LFQ9|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MAFERQEFNMSTAKFEELTQKISELLYSDALAGLKVDLQEVLRLIHLLQVYQLELEMQNE
ELRKTQIALQQSQQDRQLHDKKTDFGFLTLNAAGLILKSNATLASILGMESKRLIGRKIS
TLISPNDQDIFHFFRQRVLKTGEFASCELNLLGRDGSHVAVQLQSEGPQQDLSGEKRWKI
IVRNRSCQNLESLSPVGIFKIDADGYCLHVNPTWLQITSVDSHAAIGSRWTESIHPEDRD
KISDTWLRATGERSPFKAKYRFLKGSGDEVWVLGQATPEIDTQGRLTGYMGTITDITAQM
TTEQMLLTSQELAHLGSWDWDIPGGQLIWSDETYRIFGLSPQESPPTYEIFLQSIHPADR
ILVESSVEKALQDPDFNYQVEHRVVRKKGAPRYVIERGKVQRDAAGNAVRMIGTVQDITS
LRSTENQLALLERILEHTDEGVFISDQKASITSVNPALCALYGYPPEEIIGQTPNLFISH
HQDHIFYARMWQTLLKEGYWENEIWNRRKDGEVFPVKATIQAVHNLYGEITHFVCIYRDL
SDIKKRDEKLLFTRSHDALTGLPNRVLFLDRLGQALRQIQREKRQVAVVMLDMDLFRKIN
DSLGHALGDLLLKQIALRIQALLRSEDTLCRLGGNAFTIFLQHLESMDGVTQFAQRLLGA
LAKPFQVQEYSLHLSASIGLTIAPNDGDEAETLLKNAELAMYRAKERGRGCFHFFNPHLS
EQANQRLALENNLRQGLDQQEFLLHHQPKVDLLSGQIVGMESLVRWNRGEQLVSPDAFIP
VAEESGLIIPLGSWVLRQACLETVKLPAAGDSLRVAVNLSPRQFRDPKLLQHIDESLLHS
GLPPERLELEITESMLAENVEEAIASLNQLKDRGIHIAMDDFGTGYSSLNTLKRFPIDTL
KIDQSFIRDLTSDSEDAQIVTAIVHMAQSLNLKLVAEGVETREQLAFLESRGCDQIQGYL
FSKPLPYSQFSVLLTQGKSLKSKPATAL
>A0A1S7LHL6|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MIDQIDTRQYAGEAFSSLTLFRDISWEEVAPILQRCAMSSLQPGEVLLDPVHPNERLYMI
LDGCLTIHLKSKDTPAITSLWRGNFVGELSLIDQKYPTAYVVVEEEALLLAITRDILEQL
VEESSTFVFNLLQVFSNRMRFSTDALIESHFVRTVPDIIYRLDAQGRFVYLNESVEKLGF
EPEELLGEHFSRLINASEVESVSFSQAVVRQRAGESLEEGSQPKLFDERRTGERRTQGLE
LQMLKKVGRGALDSHEEAIFAEVSCTGIQVDSLKGGEKVYHGTIGIIRDVTERHLFLSQL
SEQKAKIEAIFNTMADALLVTDSQGVIESVNHSACEIFGYSERELLGLSVDTLLPNGSDS
TDSEKLGGHWRHMAGQRQEVHAKRKSGRHFEAELSVSRVGLESRVLYTGIIRDITERKEA
ERRITYQANYDALTGIPNRNHFQTLLGEAIVRAEEKQRQVGLIFIDLDRFKWVNDTLGHG
AGDTLLQSSSKRVASCLKSRDIVARLGGDEFVAILEDVGSPEQSRESIRAVAKRVLESLN
KPFTLHGQEVYISGSLGVALYPDDAPDKDQLLKRADEAMYAAKHAGRNACHFVVGEPFNL
PKNYDVATAKR
>A0A485AT47|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MNKDSTFTSRPTFKKTLRRINMISVIVTMTLIWLLLCFASVVTLKQYAQKNLELTGASMS
HTLEAALVFNDPQAANETLATLGQQGQFAMANVLDIHDKQFAHWVWNPEDSSDTLGALVS
HWLFPVPISQPIMHNGQPIGEIRLAARDTLIGHFIWTSFAVLTGCILFASIIALTITRSL
HHGMVEEIQNITDVVHDARKNRNFSRRVKEGRIEEFHRLGEDFNSLLDEMEEWQMKLQEK
NAQLMRTAMHDPLTGLANRAAFRNSIAALMTNSAAKTNSALLFLDGDNFKQINDTWGHAA
GDCVLIEVASRMIEFGGQRYQSYRLGGDEFAMVITGVHSEVDVQHISAALAQQFSRPFDL
HNGHHTPMSLSIGFALAWENKLAGNVTGKSGP
>A0A840Y453|diguanylate cyclase|EC 2.7.7.65|Roseomonas pecuniae|TrEMBL
MTARVLVVDDIAANLKLLEARLNAEYYEVALASSGTEALRLAQLWSPDVILLDVMMPGMD
GYEVCRVLKASPVTAHIPVVMITALVDQAERVRGLEAGADDFLSKPVDHATLFARLRALL
RTKQVLDAFRLRAETARDLGFEPMPDPSRSVAGAHALLATEDDAEAASLASILAQDGVTV
TRAADAAGAWQRLLEENVDLAVLSLWLDDGEGLRLASRMRAQSSTREVPVLLIADTDQRN
QVLRGFDLGANDHVLRPVDANELRARARNQIRRKRYQERLRADLQRSLEMAVTDSLTGLR
NRRYVTRHLEGLLRAGGATLLLIDVDRFKAVNDTYGHAVGDVVLREVAERLRVHLRAVDV
VARFGGEEFVVAMAPQPADDAGMVAERLRAAVSDTPVVVGEVSLEVSISIGVAVAVPDCT
VDGLAATADVALYRAKAKGRNRVEIAGPEDWTAAELGSRQA
>A0A518VJE8|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum subsp. carotovorum|TrEMBL
MNELLNVDEQRDNGESDYNQVITSEWMQLIVTTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNNGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASIERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRSHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYENTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQTHPIYL
QNGESVTMTISAGIAVYNGHPDYECLIKAADDALYQAKANGRNRIEYAPEA
>A0A737LP42|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:f,g,t:--|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A837DRS4|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum subsp. carotovorum|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWTKLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEVMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIVSIMTETDDYIRSHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDNILKRVAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIHL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A737LIJ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:f,g,t:--|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDVTQEREKK
>A0A8F7QMY5|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MNTPAIRSRDIDAFDRYEALARLTALDRAYGMVEFDLDGRMVSVNPLFCRMFGYAPEALV
GQSHLLLLPPELHAEHGRFWQGVLKGEIHSGAFRRVIQNGDTLWIHATYMPVTDEAGTLL
GVVKLAHDITAEMLAKQRVEQQSQLFDIVVAAHQSFLLDRNLGSACDTIFERLLSVSQSS
YGFIGIMQYEEGRPSLYIPSISNVSWDEATHAWYEQQRQNRGGLTFSKLDNLFGHVVTHN
TLVCCNDLPSHPASRGVSPRGHPHLDSFLGIPIRHKGEAIGMIALANRPGGFDETQVTLL
EPLTTALGTLIHARNLEDERNRMERVLRFNAEHDFLTKLPNRSSFFHQAKVLLDHIQQHP
AEGEACCLALIDIDFFKQINDEHGHLAGDAVLEALASLLMQAVRSKDLVARFGGEEFIML
LRGTTLEEAHAIMERIRQLVEQHSFAYQRQAIAVTISVGLTPYQMSYRRMDDWLQCVDQR
LYEAKRWGRNRVA
>A0A8F7QLX3|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MLQDNDTLTIPDLNEAVMRGILEVVSDGIWDWNANTGYVYRNPGWYQMLGYEPHSLDNNV
FTWENVIHPDDLARVMERFDAYLSGKVPDYRVEYRCRCRNGDYLWVEDRGLIVARNPDGS
VARMIGAHRNIHAQRELYARLELHNRSLEQQVAERTAELERLNLMLQHQVEENRRLAETD
SLTGAASRYRLEQAVRLEYERARRFKEPFAVIAMDVDDFKQINDRYGHGVGDQTLIDIVR
LTRGSIREIDLLARWGGDEFMLVLPNTRLPDALMVAEKLRQRLGYARVKGVEPVTLSFGL
VESDPDEPLPQLMARVDRALYRAKLAGKDQLCG
>A0A8F7LXY1|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MLTFRRTQKNFTFITGYLWLLALPMLLGIGGLFALSVYNHGVVVEQKLASLNGMAVVTED
RMLDHLEQLMSVEVTADLLTPVFSSSEARQVYRERWGNMAALDPLVTLIFHADSNGYFFS
GSKEADQAWVNARANVRSRAWFKGALEARTFYWTPAYQDILTGDYILTLAHRLTDGRQQG
EQGERVIGIDVNVAQWSKMLRDMLYGDNAVSHMVIDRRTHQILVSSQSANNGQILQAPWL
ARLTAHSGSFYSDLSNEYVAYGTLPDREHWMAITVQPRRDSVAAMGGGLALGLLVITCAL
FITMSAFFRLRLLVLIDNLAGRIRRLGAGSREAHPVSVLPAFPEMALLDQELDQVSDHLQ
ESFDLAHRDALTGSYNRRFLDQRLRQLHEEGNSFVLALVDLDNFKQLNDVYGHAGGDAAL
CRSVELGQTLLGEGVLLCRYGGEELVALFEQHSLAEAERLMELWRCQLSEQKWREKGMRV
TFSAGIGASLGRSPEVLIALVDKAMYQAKRAGKNRIHRIEEA
>A0A737RHW0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sendai|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPLDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A174Z4K7|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MSINKKEFNLEQVVKLCVVVNISLFLFVAFMLILFVYFNITPMIYYSVIAMIGYVLYFML
LKRQKVCAYMWCVYATIIIYMAIATICLGYKCGFNLYSMSLIPIIFYSQYISTKTDTKDP
NPLAVSIAIVAVSIISSAIAIINGPLYEINKTIISVMLACNAISVSAFLIYYTKVIVDLV
IESEKKLNSIANIDLLTDLYSRRYMINYLEEYDADDEGWLAMADVDDFKKINDTYGHNCG
DYVLNFIAQKMKNICSNCVISRWGGEEFLIHNGTHDSTHEVLEKLRREIENSECIYKQQK
INISLTIGVAQRNADGDIEEWIKHADDRLYYGKNNGKNMVVD
>A0A5C1C481|diguanylate cyclase|EC 2.7.7.65|Enterobacter chengduensis|TrEMBL
MDKDFTSTQRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPIAQPIMHNGATIGEIRLTARDSLIGHFIWMSFAVLTGCILFATVVALAITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTKSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSEPEVQHICAALSQQFLRPFDL
HNGQQASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTIS
>A0A1F2PGL5|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNKKKTQSATTVIGEDKDSEERLRRLVDILKHPSYSIQEFLDYALTQAIELTGSQIGYIY
HYHEDREEFILNTWSEEVMEACHVEKLETVYHLEKTGIWGESVRQRRPIVINNYQQKNPL
KRGYPKGHVPLYNFLTIPVFKNQEIVGVVGLANKATDYVERDILNITLLMESVWTVTETK
KAEQALAQSNARYDKLVQRIPVGIYTMRRKSTGETRFEYCSEKFCQMLGLTVAEVLADTE
AVDRAIFPDDRKSLRAAKKGAASRGQSFRWEGRSQIGGAIRWIRFESEPTPLKNGDCLWN
GVLLDISEQKQAEEELKRTSTRLTLATRAGRVGIWDWDILSNQMLFDDLMLELYDLPEKN
YWVPEQIWKQVIHPDDLEQLIAALEQAIREKQEYNFEFRVVWQDGSIHTIRALATVQYDE
GGNAVRMIGTNWDISEEKEAHARIIETNRRLQDEIIERRYIEEALRASEEKFKAIIETSP
DGIAISSMDGVVEFATEKSYSMWGLDSMAECVGKNILEFIHESHQQKAIYYVTEMIKGNL
TGAAEYLMVRKDGSHFYCEVNANILRDNNNNPIGVLYMERDVTERKRLEEELKELAIKDQ
LTGLYNRRKIDEVLKQQKSAADDMVRDLSVIMVDIDFFKKVNDQFGHQVGDQVLTEITEI
LAKGIRRNDVLGRWGGEEFIIISTDTDLSGAMVLAEKLRVMIESHVFRQVGKKTCSFGVS
QLRKNETIDALLIRSDQALYRAKSQGRNRVVAES
>A0A558JF34|diguanylate cyclase|EC 2.7.7.65|Halomonas titanicae|TrEMBL
MRYKDKHQLAAEWQTLLERTPRPLRQAVETLVTQHCGYFADHFYSVMLEDPHASLFLSNE
QVEQRLNPSMRRWLKAMFAVEHVDFEALVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YQQLSATFKSPLSPGDASVYVSEHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQDIATLPKLANSDFGLWYFHKACHAFEGAPEIATIS
RHIQQVDREWLEVLLHEDASQRLKALGEIRDAARTVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIVRHSEHCFALLMVDIDHFKSINDTHGHDAGDTVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDHDGSRLFAERLRQAVAKEPMLAGADTLLNVTISVGVT
LYDGHPDYNHSLQRADQALYQAKRGGRNRVVVHEGVESEHKLG
>A0A1C5NG11|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKFKAASRETVVKRLRKRIELQEESSKRVNMEAWRNALYKRSEYDELTGVLNRRGIRKYM
VQAFSDAKAVGNKFAVLIIDVDFFKEYNDTYGHVAGDEFLLAIGGS
>A0A8F5Q3A4|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
METPAKSLRLASVYGVSLLIIFMVPLLLWQSTTAKTVTAVDWFDVVTEGALFVLGMCWLM
VMVSVRPSGRVTNLLIAGLSSYCLGCYLDLLDEIFIVKTIPVYNWFEKMPTPVGLLVLTY
GLWLWRDEQTVVNRQLQTREQFHREHQLTDGLTLLNDAKAFEQHLIRQISQNQSFGLIML
DVDNFHQYNESNGVEEGDRLLSQLALWLSASLRSQDLVCRYAGDRFIILMSGAIPPLVSV
MAEQVQQGVRELGCSVSVVWTLPSPKALDRQDKQNNPKAEAATLLQLLNQKISQKKAKRA
SAAPITQPFHSRSTSTESGLN
>A0A4Z0Y449|diguanylate cyclase|EC 2.7.7.65|Caproiciproducens galactitolivorans|TrEMBL
MLKSRINTSITAILVMAAAILVIILSFSHYTLLVKNTFTEDNQKNLASEAGQDALIVRNE
LQFAEASVRGLSKVMEAQYHSLGKEEIQSFLKKMDSSDPIISLSYVQADGTCYFQDGRIL
PIADRAYFKKVMGGSIVIAPVEDSRLDGKNMIVAAAPVRLSGKTVGAVQAIIPANKIDAL
LNVNGNEDFSETNIVLGNGTIISTTNPEKRNSNIFSNTNLTFEDSNGLNLIKSNMRGGKS
GNSHYYTNKNEYFVFYMPLGIEDWYIFKTVSVSEIAFKTNKIMHYTIPLMAHLIVAMLLF
ILYMVLSDRKNRKMIRNKNDELRSTKVELETFIANLPGGAFRYNDSEDMEFQFVSDGLLK
MFGYSREQFLEKYHNSFCNMIYGEDRVQTLNNLRQQFTQSKFAEVKYRIVTSEGEIRWFL
NRVQIVTCEDGQRQFYAVVIDITESKQAHKKANDAMKQLLTLANSIPGGVAQYAYEDGKL
KLVYASEGFYRLCGYTEEEYKSKEHEGIENVHPDDARFLSSMISRQIAEKRPIMAEFRMV
QRDGKVIWVSLSGTRTVNQNQQVFYQCVFSDITTLKMTQEELEVEQERYQIAENLSDDIM
FEYDIPADCMEFSPLFTALTGRHPNISGFLENILQNESICDKDLPEFKAYLNKLRMGNAD
SETEVRFITKSNEFIWHRIKAKIIYDSYGRPSKAVGKAYNIDKQKKEMQRLLDKSQRDPL
TNLFNKTATQSQIEDHLAESAPVERHALMMLDIDNFKAINDQFGHMTGDEVIMEISHRLQ
KLFRTSDVVGRIGGDEFVVFLRDISADDLIEQKAKAMCEIFRTTHASKDLSYQISGSIGI
ALFPEDGKTYQELYPKADAALYKAKRRGKDCYEFYSEEDDFCD
>A0A8G0TBW2|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MHLPAFQTTHLRLAIIFGVFGLVLNLFPIPLFANVQLILGNVAVVIVAILLGPWYALITA
LFTATGLMIVWSSPHVYLLFLLEALWLGFARRRDIQILYASVSYWVLLGIPLLAIYVAVI
AKMPASHIPFTAIKQAVNGMIYAAIGELCVVAIPSLWHFKGKLTNLNRRTFSSQLSYLFT
LIITVSLLVSSLAFNHFFIDKQQVMINRNLDDTATHLSHATDNYLAYNTQVIASTAKFLS
LSNAGINEWQALLSSIHDSNQGFKTMLIANEQGNLLAASPMANIVELDRLAEIPSVMDRE
YFIQAFYNHKTFVSPAFIGRGFGNDVIVAISAPIFSPNAPNQARGIVEGSLDLRYFSSID
KQNLHHEQQSILLTDENNNLIYASEGLGLAPFTPLSFSKGSEIYRARLQLMNLHNLDSNT
PEYIYAQHKLNNGWQLYVLEPFVPLLKLAERQYVNTVILLFCSLVGAFFITKAISKLLTE
PLSLLAQHFGPAKQEKVSDEKFEHDLLDKSTPKEIYSLYESLASNQQTLLEHQQELEQKV
QQRTQDLEAANVKLKDLAERDPLTNLYNRRYTEHQFPLIQQMCERGQDAMTLAIMDLDHF
KQINDTYGHLGGDECLKVVAKLLTLLFKRDIDLISRYGGEEFLLILPMCNALKVEAHLNE
FKQQLADTVIINPQDNRSFNVTASIGAVIANATYSDSLEHWLKQADNNLYLAKEQGRDRV
VCSLIV
>A0A8G0TC62|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MDKKPLELVYPFITEALRLSENGLAVLDKHNHFIFYNNTFAKMFGFVEQDMVGKHFDDMM
RFAFTHKQGPNIEHETIEEWLELIHTNQRKSAFRRFEVDLVDGCWLQLSEQVYHNGDMVI
VCTDITQLKQVEFALRNAQTELNRLALTDELTGIANRRHFFQQLEHEIKRLGRLQLPLCL
VMMDIDNFKLVNDRYGHQVGDKILQHFTQFISTRTRPYDIFGRLGGEEFALLLPETTVDT
AQKIVMRMMSSLANEDISAIVADFQYQFSAGVSALTPVIIRHSIDNSTDIADVEQVALPI
GTGSQCRSDAEKLVAEADKALYHAKTLGRNRAVIWDEVMLPRHKPS
>A0A1F2Q1Y8|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MESAESVERSDAVASQRPLSGPAFRLISSQLVDWYRRPDQFDTFNRYLADKGLTVASRFL
VVCSLVLVTVIMSLTRFSPQGPTTPHARTANAVIIVITVMMAVALSTRRNLSRSWSYAFV
LYSEVGIAAAMLLYSNPLAALAHAVMFSVIGGYIAFFHNARIQSLHMLWVFVVVIGIVTR
ISVVENYSDVPVLVALTVLVGAAIYVIPFACQFIFSILGTDALNSQLDPLTGLLNRRGLA
DEVRLLLERSYANSALVVVAAVDIDRFKTINDEYGHTVGDAVIEKVGSRLVECAGPAALI
ARIGGDEFIIVDSGDQRSVDRLEQELQRSTVTAPGHSEVALSVGIAKVAGPFESPDDALI
AYPTLLRRADRAMYAAKARGGHSVVLLTETD
>A0A3S4NN98|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MVSIEQMALVLDALPDPAFILSQSGRYVAVFGGKDERYYHDGSGLVGLYLSDVLNDEKTT
YYLNIIQQALDSRKLLIEEYELSNKDVKGLPDEGPSQPIWFEGRIQALDFLVNNEPVVLW
VASNISKRHKLELQLRQLSDTDQLTGLYNRRRLDRDLQLLFDTFSRHRIPASILVLDLDH
LKRINDQLGHQAGDRVIMAVAEACQQQFRKTDSAYRFGGDEFVIALPGVDHDQAIVFAEY
LCDCCFKALQQLSVKGLFATVSIGVASIEAGDKSYEDTLKRADTALYQAKRDGKNRVIAN
SA
>A0A498PYG2|diguanylate cyclase|EC 2.7.7.65|Mycobacterium attenuatum|TrEMBL
MNAPHLPVPAASSSPPQCALFDYVSGMERLLQAVQELSLARSLPDIQQIVRSSARELLGC
DGATFVLREQDTCYYAEEDAIAPLWKGSRFPVEACISGWAMLNRAAAVVPDIYGDPRIPH
TIYRPTFVKSLVMVPIRKLDPIGAIGNYWAQLHRPTEQEVCLLQALADSTSIAMENVQVY
AEMERRVRDRTAALEKGHEEIRRLSVTDELTGLNNRRGFYLLADAALGAARRQGRDCILA
FLDVDGLKRVNDQLGHDVGDTLIADVARVLRCALPESAILARMGGDEFCALVTDVDCDSA
TLKTLLVAGFRHFNEASHRSYRVSASIGVVSARAADVSTVDELLAQADELMYAEKKASPS
SRLAD
>A0A376DE37|diguanylate cyclase|EC 2.7.7.65|Edwardsiella hoshinae|TrEMBL
MCCSWQRKKGNRVKRLFSKRVSSHRTRPTLRRMFQRIHLMIIAVTLLLAGIPLSLLSLFT
LRSYAEHNLHLVAMTISYTSEAAVVFNDKSAALDALNMIAKHEQIAEATISNAQHQVWVR
WQSPAPSNERVNRLLRGWLLPSAVTGPIEHKGQLIGYVSLKADGAMLVHFLGYVLLGMLC
CLILIALLSLCLVQRMHTGIVDELYAIAKVARQVRERRTYSLRVPHSQIAEIEELSRGFN
SLLMEVESQHDSLVNENGVLSYKALHDPLTGLPNRTCFMNMLESFDLQQEQVCVMFLDGD
GFKSINDSWGHAAGDRVLIEVAHRLSQQIRKTDMVARLGGDEFAILLRNIEHSREAERVA
NGILRAVPQPITLANGVQVSMTFSIGFTFSSPASQLNELLERADSAMYQSKQRGGGWSIG
>W7W8W6|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MWAALARPAVAAVVLVAVATAASASVFSHFRYVYVSVALMLVAAVGGFAGAATGGLLASL
SVGIVIALGLFQPGPGEGWLETVAFYLPVVLTLVPPLLLAAAMERNRQHVHEIEDREAQF
RTLYERTPVMMHSVDVERRLVAVNDAWLARLGYERSEVLGRRSTEFLTTESRERAERSII
PRFMREGELRDMDYQMVTRSGEVLDVQISAIWETDAHGQPLRTLAVLKDVTEQKRLALEL
AAEKERIEVTLHSIGDGVISTDEAGRITYLNPVAEQMVGCLLAQARGLPFAQVVQLFDQE
SGAPLPSPVEQCLQDREVYGVRESAALRHRSGRDYGVQISAAPIAGRDGRVLGAVMVFQD
VTEARGLAQKMSYLAHHDGLTGLPNRVLFQDRVHQACQSGRRHGRRFAVIFMDLDHFKHV
NDSLGHAVGDELLKAVAQRLTGALRASDTICRLGGDEFVVLLSDLDDVEVDGVAEVAKKI
LRQVAQPCVLGGTEVNVGASLGIALFPGDGEDPDTLMKRADAAMYRSKREGRNRYHFFSK
AVDDAASARLQLEADMRRALAAGQFIVHYQPVVHGRTRDAVAVEALLRWDRAGQGLQSPA
VFIRWPRRAA
>A0A378J2T7|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MLSANMIPRHELQQVIIQLEQALSEHLQWHSTLLRALVCHLPIDNNNLQADGHHQCIFGQ
WLSTSAPKELNDYPGFLTIDEAHKKIHLLALQLVKEAATGTISPVNYDLFTSALAYLQLE
ITALKSELESLLYNRDALTGAISQLGILPILREQQELAKRQGQNCCIAMVDLDHFSEINE
QHGRYIGDKVLAAIAHYLIDNLRPYDRVFRYGGEEFLLCIPFTALAPGQKVVERLRKGLA
TITIDAGQQETIRMTVSIGLALLDPHLPIEQCIDHSMHAMSAAKAAGRNCVQIWETSNE
>A0A1D2IM45|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. AVP053U2|TrEMBL
MEAESEPYVRLASLRQLHRGMADMNTARSLADTLQTVADGVVDALGYELACVNLVRPDGD
LVVAAFSGNAAAEALITGRVGSRESWERRLSMGESWGDLIFIPHTEGWVLDDDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYAPGPQGGGAGELVGVLSVDRPRNGRLPGAWGREALQMY
AFQAAIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYAPSGMAVAEMGGDQHG
RILRTNDALCRLLGRPASAMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLARRDGTYVW
VSLRNSVVADAADGPRFLLSHVEDIEDRKRRELHLAHRASHDSLTGLPNSAELRARLSAR
LCRQRPSVLPAAVDEAMAAFESFDSQDAAHGPPAFDRGHDFDFPPEGEGLEGYDHHVHAI
APDGDRDDGAKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLSNGVRDGDTVARLG
GDEFVILANGLGRADAQDLAVRLRNEIIQPIRAEGRAVRVGASFGIGWAHCGMTADEVLK
SADERMYVEKRSRPKQHRRAG
>A0A6J5G778|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia caffeinitolerans|TrEMBL
MQHSAKRKSGQTRPDRFSSIVMKRPLLVVTLCFAGAMALVTLVGVRQLYNLARSDLQNRQ
RDLEVRAVGVDALIDAERRHLVALRNYAEHVLAAEEQQRIGVESPAVQTALGQTSQPVWQ
VPGLLGGPAVFGTNAANLAGLDGFHRDPAALPGDIALSRALSPLVEISHQADAMRSAVAF
ISPNGMFVSAPEHQGMSTAELLRHFSAMYYYRGQLPEHNPRRDVLWTPVYTGLQNGEAVS
TLSAPVYLRNQFRGVVVMDITQSRLLSLRLSTGNAEDDVDPLEFGLLNTNGSIVYFRDGA
VIEQRPTRFSPKLLKTAAKSVDTWMQQGSGYIERNGQYLLYRRIGQSHWILLAATDNAEL
TIATARRVLGSPLIAAWIVLGLLLIGTLRIVTNIFSHYVEASERLETLARSDPLTGLANR
RRFQEVFAEAHERANRAPQQPASLAVLMLDIDFFKRVNDRFGHAAGDRVLTILASILRAN
LRGVDLPARMGGEEFAALLPDTDLAAATAVAERVRLAIESHARDATVPASTEHPEAITFT
VSIGVATSPVDGPIDYEALMHVADERLYLAKQNGRNRVVHASAPAPDVKA
>A0A1S8RBY0|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MDNKLTSKEELIIKMEELISNNEGPFSIVVADIDDFKNLNNLYGNSIGDEVIKKLISILN
NNLSSTDMIFRSGDEFNILLVKKGAERSFMELEEIRRYLSDNTFNLDENSDDNVYFTLSF
GVASYPRDAKNVVELFRVADSALFRAKELGKNRVCLSEAESMVLKSNYFTKTQLDRLSRL
SKANDRTEAFLLREALDDLFKKYSK
>A0A0P1I5M3|diguanylate cyclase|EC 2.7.7.65|Shimia thalassica|TrEMBL
MLEAFCPMHVVLDKTGHIKHAGPTLRKLMPDETVVGKRFLEVFELMRPRSVNTMAQLREV
SGQRLRVRKRCAPQTILKGGLVNIETEEVSVINLSFGFSVMEGVRDYALTSADFAATDLT
IEMLYLIEAKSAAMEASRKLNQRLQGAMIAAEEQAFTDTLTGLKNRRALDMILARWLESG
RPLVVAQMDLDYFKRVNDTFGHAAGDHVLQTVARILVEETREGDCVARIGGDEFVLLLSG
ALSDKKLAGFANRVIARIEKPIPFNADECKISTSLGFAPSATTAGLSAETLLVQADTALY
DAKRRGRAQHRVYTPEMDLAVPPEKGDAPVAEQSDPPN
>A0A8F8S2G7|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. USK10|TrEMBL
MALGIPRLGVGIVRYDVVNGTLWWDEKAAAIFGDDGSLSPLELWRERVHSEDVGTVRRMF
GDTAGSVGAECVFRIVLADRSTRYILTRSIDVTTDASGAPVELTGVVIELGHVAGRDAQL
ASLLDRVGLGFLALDEDLRIIYVNSVCLRHVRRSRDELLGRVVTEVLPETQGSYFDALCR
KVLATGTQQQARVDSLYWPGATIEVTAAADAGALVVHFRDVTAEVTAQKRAEEAHALLLH
EATHDSLTGLLNRAAITEHLQRLFEPGVGPAVALFLDVDGFKEVNDTRGHRVGDRILQAV
SEHLRHAMRAPSAVGRLGGDEFVAILPDVDQLAVDDVVDRMLASITTPIDVGDELLVVTI
SVGMAHSTSARTVDELLHHADIALYAAKRRGGNTAVWHE
>A0A7X0PBP5|diguanylate cyclase|EC 2.7.7.65|Acidovorax soli|TrEMBL
MDPLLSRLSDSVVQAKTLEQLTRPLLEMLGTITRLESTYLTTIDLQRAVQHVLFSRNTRK
MQIPEGLTVPWGDTLCYRALKEGRMFTADVQGCWGDSDAAAALGIQTYVSMPVRLSDGAV
YGTLCAASAEPAELSPDTEKMLQLFASIIAQQVEREHLLEELQRKNSLLSTMALIDSLTG
LPNRRALFDELERLQARARRSHGQVMVAFLDLDGFKQVNDEHGHEAGDALLCAIAGQLRL
ALRESDYVGRFGGDEFVFVGPGPQKGQDSAEAVRSLRHRLEEATVCRVTLADHRTLEYPG
ASVGVICVDPELCTADLAIRHADQAMYAAKQERRMVVHH
>A0A8F9UZ95|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MATKNSAPLASFIDLLLDAVCAVDVEGRFVFVSAACERVFGYTADELIGRPMIELVHPAD
RERTLQAAREIMGGVPKPNFENRYVRKDGRVAHILWSARWSEVDQLRIAVARDITERKQA
ESRQAALYAISEAAHATEDLLVLFRHVHRIIGEWLPALNCSLALYDERSASLSFPYHVDD
CEGSPELPGTLIERFCVEVLQCGQPLLLAPECPVNRVLWSEFAAIQGSRCWLGVPLNSQK
GTIGVLMVKSAPGTESYSEQDQELLQYVSAQLAAAIERKQLHARLHYMAEYDQLTHLPNR
ELLRERLRSALARARRESGRMALLYVDLDKFKEVNDTCGHAVGDMLLQAVANRLKGCVRE
TDTVARIGGDEFVILLESVQHSEDAQRVAEKIRRTLGEPLRLDGHSLNILPSIGIGLYPE
HGLEEKQLFKHADEAMYAVKRAQKSRSNA
>V5C1L9|diguanylate cyclase|EC 2.7.7.65|Methyloglobulus morosus KoM1|TrEMBL
MAERQQDSWLKNLRYIAMTTLLFYMAGRLSFPLTWSQNYAGAVWPPAGIELGAVLLWGYA
MLPGIYLAELLLHYEAFFVADTALKQVVFFLAPLSSVLRVWLATVLVRRYAGFPNTLISI
RAILLFFLCACPVATFLPALLSVIALRANGIILESNFLFTFLTWWVGDCSGIAIFTPLFF
IVFNKSHRIWRQRLFSLGLPLMVIFSIVAMGYLYAQNKEFGRLQNLVSNQTGAVKDALLD
EYSIHVSVLGRIKDVVALNPFNETYFRFSAQTALTQHPDLVGIEWLSAQKINQGYRFNRQ
IFETRQFGRPVNFYSIPKLLSTLNIAQGSIALLGKQHYLIAVPNYEMGLNTCQCMTGVVV
GVFDIKAFLYDAMHRGNYRQIVVKLMDDVSNPQVESVFGMNDDEDMADRFGLAKWETIKL
GNKDWYLQVMPKPIFLSENYSWSPWQLLIGGMFLTGVMSIGLLALTGHTEFVADQVDKRT
QELKRSNIKLAAREQQFRKLVQTQSAIVWRADPVTFRFVFVSAEAASILGYPVKQWLDEP
DFWQKHLHEDDKENVLNLCARGSISTHNQNFDQEYRMIAEDGHIVWLRDISTLVVESGVI
TELYGFMIDITRQKHSEEQLRLAANTFESQQGIMITDKEAKILRVNKAFTQITGFSAVQV
IGDNPRILKSGRHDQAFFEDYWRQLLTNDKFEGEIWNRRKNGEVYPEWQTVTAVRNNQGE
VSHYVSVFSDITEKKDAENKIHNMAFYDPLTNLPNRRLLLDRFDHEIAIAKRYKQFGSVL
YLDLDHFKILNDSQGHLVGDELLIQVAARLSEVLREEDTPARLGGDEFVVLLHANSESLS
AAADHAMTVAEKIREQINAPFVLGQYQHQIGTSIGIALFPGDQESPDGVLQQADTAMYRS
KSSGRNAINFFQPSMQEAADLRLSLEQDLRGAIDKGRFILCYHPQMDIKGEIVGAEALIR
WEDSLKGRLSPADFIPVAEESNLILTIGKWVLMEACNQIKMWQDDGLAVLPYVSINVSSR
QFRQQDFVDQVKYALESTGIAPSRLGIELTESVMIVDTNDTVDKMKALKALGVSIAVDDF
GTGYSSLVYLKQLPLDVLKIDRGFVRDILSDSSDAVIVETIISMAKHLNIKVIAEGVETL
EQLVFLKEKGCTIFQGYYFDEPLTAANFAETYLKQEL
>Q8EF60|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MSLEESLEQLKRQYLHALPDKKKQIITLWVSLRKNWQSYMLSAVYREVHNLKGSSETFGL
TETKDIVDKLELQLKNLLDAPAPTLNLIKGLDTLFHQLLQNNQHYLPAAPVVEAQMQQNP
YNPSKARHEYCIAIIEDDNNVGAMITKQLHEFGFNVQHFLNFTDFIKVQYASPFDLILLD
LILPDYTEDALFEAACEFEKNNTRVFVLSSRSDFDMRLLAIRANVSEYFVKPAETTLLVR
KIHQWLKMSDKPPLKVLLVDDQQSMVDYFSSLLRSHGLMVRGMTKPEQVIPTLEQFEPDL
FIFDLYMPGVNGLELARMIRQLDKYTSSPILVLSSDDTMQNKVSIIQAGSDDLISKQTAP
SLFVTQVISRAQRGHDIRSSASRDSLTGLLNHTQILVAARHCINLAKRANSSVCIAMLDL
DHFKQVNDTYGHSGGDKVLLAFAHLLQQSLRAADFMGRYGGEEFMLVIPDMPAPLVIAKV
NAIRESFSNIVFVEEGAEFKVTLSGGLAFSTECHEFQECLLLADKNLYEAKRTGRNRIIN
TLVK
>A0A0D8FSG3|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MSCRLSGSEYIDSAQLPTRLVTGVENVERLNGVDNLQLSGHLGDKDFDAIVASLGIGCHV
PIAVVNIVTPGKQTYAAEIGVGESSTSVPDEESFCAEVVNTGRSLVVADAATHRVYRANP
LVRDHVVAAYAGEPLVDNGIVIGSVAIFDSQPREFTSDELSLLRHLAQLASAVLGLRRAA
MTDSLTGLPNRAWCVEYIQRAVAQLLGTGQLLAVLFVDLDGFKEINDHFGHAVGDHVLKV
MAAAMRSHIRPTDSLARLGGDEFVIICPDLGEPSDAVRIGERLLRAADDSMSFETGAAAN
ISLSVGIAVTGDPHESVDNLLRRADGAMYRAKLRLGSAVELAVVT
>A0A0D8FVV1|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MLWQWGIEDEKAWNLHVEGINALFSEWVRLATKAVEDDASLFGDLSLEFQTADWFHSHLE
AYRLTFCASPETPASRDSARRVGFAHIYAHVPPSVYVGLYNLMFSGYHALEADPQAPDLP
PLLTVRRRWLSDMQTALDTYASALSGLVSSWSSLASIDPLTGTLNRRGLWQHITSDIASP
SSPAAFIVWDLDHFKTINDRHGHPEGDRVLQQLAALERRQSRVNDALGRLGGDEFVWWAP
GLLDRVALCERIQGFARVLYRQEGMTFSAGVARYPLDGTTADHLYAAADAALYRAKHAGR
RRWCMAGTEAVYPTLRS
>A0A1M9IIZ3|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MVTTYPGRNGFGSESNRCSRGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLA
ATGMSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVA
FVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTML
LANLFAGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVV
VVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPDI
DYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAK
KAG
>A0A0P1FEL0|diguanylate cyclase|EC 2.7.7.65|Shimia marina|TrEMBL
MTQTVRSVFFLTCAALCVVSLVVLLFLPQVLSLEDDTPPPSGPIYNFEHAIFETGKRASL
QGLWWFKFGTHLPPDDALDAFQNDTLQKLEVPHDWANDVPKTNTNPFADGIATYAALLNL
PPLHQQQLVVALPRVHDAYRIFWVPLDAPEDSLEIGADGTMSGPIVASHGTRAYALEGVR
EGLLVIHVRKSLSSFGGILSAPFIAEAGSYQDRLQVRRVMEGAIMGTTLLVALFNLFLFL
AYRKDPASLLLALTAAALLLRAVILSGTLEILFGGDIRPLRVRLEYSSVLILAWAAYAMH
QTLIWQKFGELRGPLLFAMVGMLGVALIFVAPLPVVTADLIFLQIYCVVVIGLMLMTSAR
AIAQRQKDAWFYTLGWLVPLSAGIHDVHISQAYDGVYLLNLAFVIFVCVYSLKLGRRVAA
GITRADIVEEERGLRAQLARRANAMEGHDPLTGLPNRAHFEDELALAWHQKDRSRDGLTL
LLLEIDNYSALRDCLGANAAQSLLRQVANALRTNGLRRLDVLARINEAEFAVLLSDTNID
NARLVADRLRHGIEALSTLCDGDNLLCVTASGGLTQAKPCDTRYPTAFAMMDSARHALQQ
AKAAGKNRVISADNPAEPS
>A0A0T9KSI1|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYKTEEIIGQSFELF
YTPEDLANELPAKGLRHTNQFGHYENQGWRVRKNGKRFWGHITLSALHDSDNNLQGFVQV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTNGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDNG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVTTWNHGAERN
IGYASNEIISQHFGCFFLPEDIAAGLPERLLKTSASNSRVEREGWLVRKDMTRFWAVTII
TVVHDNSGKLLGYAKIIRDMSARKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEEIFILWSPLQDKNQLVAINQCLTQGRHTLLPE
GSQLLSSQGERQEIRCSISPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAITQLGKDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLLNCPNKPATDVLEKVVADIASIQFHWHGQSYSFTASLGAVSL
TQQTETAAQAMRQADIACYAAKHSGRNRLSLAL
>A0A173V196|diguanylate cyclase|EC 2.7.7.65|Eubacterium ramulus|TrEMBL
MQESKNCELLFEYLRSILYDTKIETLNIFDLDEPYRKLGQGLQFLENAIGEMKSYSEALS
HGNLSVDTPPRDNFLCENLKNIHANLNHLTWQAKQVAKGDYAQTVSYLGEFSEAFNTMTG
QLHEREVSLKEEATREKAHANMLESYNQLLMQLIDRSNEDILVTSVDHQEILYRHQRTSG
DTLSNELYALCIRHLAEKNADPFQGEQAYEWIWETEDSLHRFYRITTGLMEWQGQKAYAH
IIQDITEKKQREQKLTAEAYHDSLTGIGNRQFLIEQMGELLNSKRQLTFCYCDLDHLKYI
NDTYGHLEGDWYICHFVHTIKKFIRKEDILARIGGDEFCLVLEGLPGTIARERLIDIQNA
FDRTKEKPYPKGFSFGIIEIPANHDELTVNDVIRQADYAMYQQKELHKQAYAPFLT
>A0A2X3N3M4|diguanylate cyclase|EC 2.7.7.65|Frankia sp. Ea1.12|TrEMBL
MAGATGVHLLLRDQQDQGWLVPVGNGGSVPLPEAARRRLLPASVVRYAERTREPVVVVDS
IRDDRFCRDPYFTDIDRCSLLAVPLMIRGRLRAMLLLENRMIRGAFATERLEGIMLIAGQ
LAVSLDNALVYASLERKVAERTQQLAAANRRLEQLSRTDSLTGLANRRRLEEVLDAEWHR
ARLHSTPIALAMIDIDHFKLYNDHFGHTAGDRCLQRVAAGLAASLRPTHTAARFGGEEFA
VVMPDTGPETAVELARHLRRAVVELAEPHPLVIHRIVTVSIGVAATIPAPGDEVAAFVER
ADVELYRAKRGGRDRVEGPLPRPVTR
>A0A379BGV4|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MNERSKRGAALTDHLQLLRDWWRDGVDYRWVVNALESRSALGVVKIAIGLCGLATPFISV
LTVTSPAGPDTLLGRTVLWCIAALSVVWVARWWFLPWPNVLESLVLIAAGDVCVTVVCLL
SPGYVVRSVGMLLLLIVGIYVSAFHSPRLLAVHTAWSLASAVVLAVPLFGDGDPASAAIM
ILGMVAATVVAPGLQFCYWVLRTDMLSDPLTTLLSRRGFEYHSSLVVARPGPVPVCVLMA
DLDRFKVVNDTFGHHAGDKVLVTTAERLLHNAPADSIVSRLGGEEFAIVARLSLPDALDA
AERLRAALAAPMGSISVTASIGLSIGEADVVGFHRTRRLVQDLIRCADSAMYQAKQRGGN
TVVVENIAALYGVDTRDSA
>A0A6P2EX90|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. RA8|TrEMBL
MAGPYQMKAAPKRKNEEASLAALNALRVLDSEPEPEFDAIVRTAAEICGAPISLISLIDR
DRQWFKANVGLPGTAETPREFAFCDHAVLGSDLFEVPDAMQDSRFADNPLVVGSPDIRFY
AGAPVLLNDGICVGTLCVMDRKPRRLSEKQRETLRCLSRTVAHALQGRYAIRETLRLVSR
LSEQHELLRVTLQSVADGIVTTDAEGNVSLLNPVAERLTGWSTSEAQGRGLSEVLCVIAD
ASVVASQSGSYDLLVSRGGRRYGIEKSVTPILKEDGSVLGEVCVFRDVTEQRRSYAQIAY
RATHDMLTGLANRSEFDTQLGRALHTTRTTRVRHALMYIDLDQFKRLNDACGHAAGDRLL
KQFARLLTATVRGGDTVSRLGGDEFAVILVDCALDDARRLAQEICDHMEDFRFAHGELKF
RVGASIGVVRIDDHWRSEAVLLQAADAACFAAKEAGRNRVHLWGETDLAVQAREEGLRWA
MQIEQALDENRFQLFAQRIVPLNRPANAVHAEVLLRMVARDGALVPPGAFLPAAERYNLS
SRIDRWVLLRTLHWLRSASNQARIDMLSVNLSGHSVGDPAFHVWACGKLDEAGSALCSKL
CLEITETSGVSNLVQAAAFIVALRSRGVRVALDDFGSGTASFGFLKKLSVDFLKIDGQFV
REMLTDALNEAAVRCFVDVAKVVGMKTIAEFVESPAVMSQLKRMGVDYAQGFLVHQPEPI
DGLLDDFPNAVARAPTQSVHELRTCS
>A0A602ZAA8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pensacola|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0Q0HX77|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MNAYSDNRERKLIVRFFSTIGFIATFAMACNALSNTDVILGTMLLVSAGFYAWAFSLYRA
VEKSATTILYNLYCLMLYLVITGGAEGTGPIWIFIVSPVTYSIRGLKKGTVDIIAFLFAV
IAGFIITDSFNIYDYQPEALPLRVVISFIIVALLSGFYERSREKYNEKIVALSIKNERLA
TIDHLTDLPNRRFMMKELAQLKHLHKKTKQPYVILLADVDNFKKINDNYGHDFGDEALTQ
LANILKKSLPKQAIASRWGGEEFLIALPNSDKEQGQSIAEKIHAELQKKPVRMNGNSVVL
TISIGLAQSQLTTTIAQDIKLADERLYKAKEQGKNRTCS
>A0A380BMD1|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MTDLRRWGRDEWLLLLLGGLVCYLSGRLGMATLVLQPSNITLLWLPSGIGLILCLRFGAV
AIVPLFIASFLANLPGLNNGHLSQTLLHTWVSAAIDALMPLLAARMLRWALPMGLQRARE
LLGFGIYACVIPVALSSILLAANLVWGGYIDKSYWPTMAVMLFLADALGIVLVYQVYLGW
SERFFISQRQIRASLLSILALVLIFSLAFGNQPWVLYLLLPVLVMQAFEGSFLLTCSLSS
GAFIVVICGSAKGLGPFDAGLYSAETAELAAFCFANALVLLGIALQNRQLRLSEQHREAW
QQVAFRDPLTGLLNRRGFEPQLELVDKQARLNREDYSLALLDLDHFKLINDSFGHATGDK
VLKQLAGLMQAQCRQSDAIARIGGEEFAILLPNCAPAQAVHLMERLRARVADEDFHDESG
QPIRLSISVGLVSGPAGCRSGKDLQDKADHFLYVAKAEGRNRVVQG
>A0A1V5RFZ9|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin315|TrEMBL
MFVDDRLIYSYDGNIDNRRISIIGLINHFVRLEEEDEGKVLSIEMIGNLPKSSGQFHDVY
FGNRTAQIRQLFGYDGISFIIGIFLIIISLITALIASRSLRNGRLYHSTLALGAIELCVG
LWACGGSMSTQLFIRNQLFLVVLAMTALYMLPVCVTWFVISMYSIPKPRCFMIAVLFFPI
AFVVVSALQLLGMITYITVATPVGILLFIYMLTLIGAVMYAYRRGEKNAKPFLIATGFLL
ASIVGELTLLILPHRTFINIQPFNIGVLIFGSILYSQILALGVNYLEERGRKEYLQSLAY
TDALTGLGNRRAFDEELIRLAKSGSDQKDLGVVMFDVNNLKQINDDFGHAEGDLVLKQIG
ELLSSLYGAFAKLYRIGGDEFALVCEQCSQKKMAEIKRSFSEATTGKPFTLAFGSALSSM
DSPDSIDVLFKIADRRMYQHKKMMKYDSHHKSSPIPSSIDMVEGTR
>A0A6I2IMN9|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MKMIINDLDYSLSELNIAMKDHYDWAGKFLRLSLLDGEVDSDILDPTSHQRCRFSRWLSL
RLNGNALDKEMVMAINTNHILMHDVARELMQSIIQKNVTDSLLEKYQQVQQEFIHSLDRY
KEHLFSYRNLHDALTGLPLRHLLYQEFPIFREQCQRTCRNLYLLIMDIDHFKSINDTWGH
NAGDDVLRSVALTLKDATRRTERIYRFGGEEFIILLDARNDEDAQKAAIRIREHLQQHQI
TVGDEQISVTATGGLTNVSHTDSLHEAISRADKAMYCGKNSGRNRCIMSTAAEEMIALD
>A0A1V5X888|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin193|TrEMBL
MFYSYLPNFLFGIGTVFFSLFLYSILKQNNRLTTLFALMSLSISIYVFAYGLEILSNSIS
EMKLCLIVEYFGVSFLPVLWLLFSYKFYTNKDLPARIAVALGIIPFITLFMISTNDYHHL
FYKTVDAIRENGYLLAVTGKGPFYILYVSYTTTVMIAGICCFFLSWKKTEYSFRTQSFWL
FIGSVFPLAFSLIYIFGRVKYDIIPFSFSVVGLTCFVALFRYDFLELKDIVRGYAFSQIN
EGIFVIDDKNRLIDYNAAGKATFSWLRPHNVGISIDCFAEGKCLLANNCDFFDLSVNTKG
GVKTYEFRVTPIKEKDSTVGKVFLFQDVTENKMAVERLNYMATYDTLSEIYNRSKLMEEV
ERIVFHINRYGGNMSVLMLDIDHFKSVNDKYGHLAGDLVIKGVAQNSKSMLRNIDIIGRY
GGEEFLIILPGCNKENAMAIAEEIRTSVEECRFYFGENEISITVSIGVVSVSGHDKASLQ
EIIKNADTALYIAKDSGRNTVKAAF
>A0A1V5PDJ0|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin356|TrEMBL
MSIKELQAQVFEKTPLAVTINRVIFNVRGEPVDYKLVDASPSFEKKLGLEKSKVLGKKLT
HWLLKHNSEQAKWLNEFAKVQATNELIEYSDVLEYNAFWYYVAAYKADSEHVVIILHKAE
RLKNVFAEFHKTKVGLEAMLDASKAFSESIFDNSPFSIIIYRVEGDGSKGADYIIQAANP
TCLELEGWKLEEIVGKPLAKIRPGVDEFGIISAFKKAYDTGKTVYFPARRFSEGGSCRWF
ENVIFKLPTGEVVAVYDEITKRKQAEDALLEEKEKLRVTLYSIGDGVITTDAQGRIDILN
EVTERLTGFTQDEAKGRPLTEVFKIYNETTGKACKNPVEMVLNSGSIVGLANHTVLKSRK
GEEITIADSAAPIKNQDGETLGVVLVFRDLRESKAREEQIQFLIHRDTLTGLHNRTYFEE
ELKRQNEVTRFPLTLIMGDLDGLRLINDFFGHAAGDQALKMTAEVFKSCCRSTDIVSRWA
GDTFTVLLPNTPEDVGQKIADRIKLACSEIEIADTKLSISVGCSTKIDKAEKWVAVIKRA
EDSMHKSKLLGSKSYRSTVLASLKSTLFEKSFETEEHGERLGLFCREIGLAMGLPAHVLD
EFEVLAMLHDVGKIAIDDRILQKPSALTPEEWVAMKKHPEAGFRIAQTVPELSGVADCIL
SHHERWDGKGYPNGLSGKEIPLLARILTVADAYDAMTQNRPYRKALSHEKARDELKKNSG
TQFDPQIVAIFLEYLEQVEPDI
>A0A8F9WVQ3|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESVSLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLRSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLSA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLVQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKTINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVRAIRENTEPRVTISCGV
SCWSKTGPMPLKMLVQQADEALYIAKRNGKNRLIIHQNSTTT
>A0A737NU76|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z4,z24:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A517QWE8|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan189|TrEMBL
MKRSSATIRICLGLTAMTVSIVMLAVIIGLVPDGTQEILHRRATLCETIAIKSTILVRHD
DTEGIKAGLKAILARNPDMLSAGIRHADGTLLVEAGPHSAYWMDAKADPTSGTHMSVPIH
SGGAEWGDLEARFAPVTKSGGILGHGGRLGLFVGALCFVANFFYLRRVLKHLDPSRAVPD
RVRDALNTLAEGVVVIDSEERIMLANESFSRAFGLGIDNLVGCTLSMLSWTKKNDRQPLT
KSPWSDSLKNGTKTTGDVLEMTSQEGEVRTLLVNCAPIFSGNGTTQGVLASFDDITPLEK
KKAELRQMLLLLQKSSDEIKVQNEELERLANVDPLTSCLNRRSFFERFAKLWKIAETSDG
CIACIMLDIDHFKSVNDNHGHAVGDEVIKSLAGIVHSTIGKHDLACRYGGEEFCIVMPNA
GTAAAADLAERIRFQVENTSVEGLTITSSFGVASLEMSVPDPEALVDLADQALYAAKKSG
RNRVVTADNIATVSVQSEDADPRSEAGDQASASIPFDAVTALFSALAYRDHGTAEHSRRV
ADLAVALSDGLMSSRERYILEVAALLHDIGKIGVPDAILLKPGPLTSDEWELMRAHDRIG
TQIIATSFKCEPLKEIVRTHHAFYGDVDRQPGLPVGTDIPLGARILTICDSYDAIVSDRV
YRKARSREEAFQELRRCAGSQFDPVLVERLIEVLTAASPSGECDARTAASSEAIGMARQV
APLMTAVKDSDLEGVRTFAEQVGSFANKEGMTALADRAVKLEASLGADSDLLEMLGTAHE
LLDLCKTTQRNCLDATRETADVVE
>A0A399F3F0|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MQNRVLTVWFIALASALAWLLTHWLRPDQRYEVPWLMTGVTALASLYGLPGGLLAGGVAL
GLEAATVGASDLPWLGLVLLVSALLGNRARLRLDVVLRRQSQTTRQLTLLVGALEDLSHL
TTREAVFAALPELLQRQGEGHASIWVPSGEGFRPVAFSGTPHLPGAIAPTGVVGRAYATG
QTQYVADVHKDPGYIPATPASGGSELALPLREGEQVVAVLNLERREPFPAEERQGLERFA
HAVSAQLARLSERLESELLNRLAVSLASIHSPRAILEQALEILMPTLGVQHGGILMQQGA
RMVLLASRGTSSVQASIPFSRGLVWQVYRSGRPVFIESASAHEGAALELLLEALEGLVLH
PVPLPGGERQRVVLYLGDERPRLWRQSERDLLQTACRTVGLALETALIRERLEGLLHLAR
DTVEAPPAQVYQQVLEAAVRLVPGAEKGSLLVRKGEHFYFQAVVGFDLEALAGLHFNEAD
HLRWYGEDRQGWLRGEPRIVTAEEVSIAQISRSTAPDDTLERVAAMDRMQANLTLPIPYR
GEVLALLNLDNFHDPAAFDAYSKEVARSFSTPVAAILHEVRNRNLLEEAALTDALTGLPN
RRAFDRRLSEELERAKRHGYPLSLLVMDLRGFKQVNDRLGHARGDEALVRVAQALLLERR
KSDSLFRWGGDEFAAILPHADSLGGLSVAQRYASLVETICLEGLCMGLNIGVATFPEEAN
SQQTLLQLADSRMYRAKEQGVAVLRPS
>A0A517W6E6|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MNSSLIANNQTVPQQQSVHGSYHMGSSQILRELVAFSAESDELALNTQHTDDVDQVICRK
HLRKLLTALQARDAVTLGHCRRVAFLAKGIANNLGWEGIHLKRLEVAALLHDIGKIGVPD
HIIFKPGKLTSDEIELMSHYHHIGLDVLQACRTDHEVLTILSQTRFHFSGATNGYQCIGS
DVHQGARILAIADAYDSLATDQVYRTGKKHEEIMSILMGAAGTQFDGNIICALSRWEQTE
RETFHEAIQEVNRNFQPKPLTEQEIAEANLISNIFSYLFQIESLYDGFYIVNSDFQFVLF
SPGLEQLTNLRSGDMLGNAWTNHSVPVTNQDGSMLASSEHTMNRVIASGKSMTTELMLKR
PDGRLIQIEVQSVPMFGEDGRLVGVAEIFRDLSRSLKRPQEFNQLKMAASQDALTSVANR
GELETQLAIMLNQASQNQNTAPLSIIFIDADHFKNINDTYGHAVGDEVLIELARLFQHET
YSGELVGRYGGEEFVILCPETDLEHARQKAERLRLAVNNLKLENLNNNRITASFGVAQLE
PGDSLESLFHRADNALYRAKETGRNRVCSLTCEDQMSGAVPEVVAPAQSNAGKMVFESSF
SALISSDIVVYKLGGFVNDNEARLTEVNPNRAVMRLGKAGLLPFWGKTDDRRPIEVELVF
DNATRKSTSGSRNATPRVEVMIRMTPLGWIKQPEVFQKRAARVFRLLKDYFVAE
>D5MN70|diguanylate cyclase|EC 2.7.7.65|Candidatus Methylomirabilis oxyfera|TrEMBL
MKKEHPSPLPVDRDVHRPQSAPATSLRALLVENDQVDAELLVRALTHGGFHVTSVRVDTA
EQMRAELARADWDVIVSDDALPTFDGMTALKLLRSTGKTIPFILMSGTVSDETAIEAVRA
GARDYIRKDQPARLVAAVRRELDAARIQRAQPQSGAPPMWRRIGIAPRLVSGFLVATLLF
AVLGIWSAVVYTRAVEQIVIAGAEQSARYLIVSVAELDEKSGTPDLFSNRSAYLQELVEK
LARVQKRDIGVVDSRKRVVADVITKDIGVTYTHDEGNEVALTIQDGRARTFVERSADYPA
GIRRMVVPIQAGDGKIVGALLLDYTVSYENAIWHAAVQARRIFITGLLVLAVAVGIGWIT
SWSITRPLHQLRAAAHRLGRQELDTPISMECPGEIGDLAAAFEQMRVNLVAALDARANLE
QTLAGSNRSLRRLVNRAPIAGMVLDFDGVVRMWSLDAERLYGWADREVLNRPAPGIPPDK
RDEFAVLCKRLAAGEVVTGHETTRLTKDGALLDVALSLAPWSDSRGNVTGFISIAIDNTD
RKRAEIALRDAHAEITASVRELERRTAELHLLREMTDLIQGSVSIEAAHEITQCYLPRLF
PYGTGALYVRSPSRDLLEQTSAWGDRAAHLGPTFTSGDCWALRRGQPHYVHASREPLCRH
TFAADGGEWICCPLLAYGEVLGILHVYRPERDTTSSSEQAFLTLAETVTSSLSLSLGNLR
LRETLRQQSIRDSLTGLFNRRYLDETLPREILRAARTGSTLGVMMLDIDHFKRLNDTHGH
DAGDAVLSALGRFLQHHVRGDDIACRYGGEEFTLILPGASLDAVCDRAEQLRIGVQSLVV
RFNNTQLDTITLSLGVAMWPQHGETEDLLLPAADAALYRAKQGGRNRVEIAV
>A0A1S7TSH5|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense NCPPB 1641|TrEMBL
MFTVLECVVVQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAAGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVLAVFGFWLALTSRSQAAYSPAIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWASFLLAFFLFRRLGSWQRIAAPAGSAI
FAICALHFTAMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSTTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGREETSLVGQDPDDLFKAIDGQPTYLP
RHAPVEAVRERAGQAQIFELGVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDEEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTRAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGKDHESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKAT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSEDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVSATTRKKHSV
>A0A7W6KHS9|diguanylate cyclase|EC 2.7.7.65|Martelella radicis|TrEMBL
MKSATHESIVLIGGEGAVAQTLSAMLSGWPVGFFQADFSDSDTTMAAVNAASLILVAVDD
DAPGPALACCGILKEHDSGVSAPVAIVTPERADATLRLAALRAGADDVIGLEHNLATAAA
RISALLRFRTLQSEAGTSAEAWPTAPRAAAVPDETVRVLIVAEDAAMRQDLLKSMLSLTT
TVATGNLREALYLASSQSFDLVLVHGGPVLGDGLRICGQLRCVPGMRFVPLFALCEPGGL
HENAGDAARSVDDCMEWPGETGELILRALLHLRRKRFVEALGAAVEDFADAPEMVESDTG
LLAPERFAATLNTLKREATTAGSPLYMGVVRVPEDPSGARVEAVAALIRYHLSGRDAASR
VEDGLFAILYPDRRRDDAEQAIAVLRQRLDANLSRLLGEGVQDAYQPAVDPALAIRTALT
EVN
>A0A7W6KHN8|diguanylate cyclase|EC 2.7.7.65|Martelella radicis|TrEMBL
MGALIVMGYGMVLRHFRGKWYEDYASAVVLACGALAAMTNPIVLETGYIFDARAVFIALA
GPFAGPGGAVLVAACTALPRIMIGGDGMMAGVAGIIIAAAAGIIFTWIVPQKRTPGSFLL
LGCLAALMVLSLFLLEFHTALALMESIGFTLTLVNILGIVLLGSALEATKRSADYLRDVE
FNAERDPLTGLYNRRALEQFEHSLGQSVAPDKRFGCVVLFDIDRFKSVNDRYGHARGDEV
LQRIANTVTSRMRRSDLVVRYGGEEIAVVLLSTSVDDAFRIAEHIRSLVEKLVFSHQRES
FSVTISAGIAAFTVGETQLEEAFDYADRALYQAKNAGRNRTEILNVPVTHEVPVRANA
>A0A1A8XLN8|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MLRVAIDDNYPPYVFRDGSGRLMGYLVDSWKLWERKTGVRVELLGSDWSTAQQRMANREV
EVLDTAFRTPERERLLDFSAPYEPIPVSIYTHSSIGGIVDLDTLHGFLVGVKAGDACVEE
LAAAGIDTVQLFASYQALVRGAVEGRVRVFCLDEPPANYLLYLNSAEQWFNKAFTLYSGE
FHRAVHKGDAATLALLQRGFTEITAGEEKALREKWMGIPFALSPHTRYLGYALLVGSLVG
ALLLIWVVTLRRVVRQRTAKLEATLAAIPDLMFELGLDGRYHDYHSPRTDLLAAPPEVLL
GKRVSDVLPPDAAAVCLSALQEALTTGHSVGRQFELPLAHGRFWFELSVARKPAKVGDET
RFVVISRDITERKRVEEALRASEALKASVLASAACGIVATDRQGLITVFNPGAEAIFGYC
ADEVVGRVTPTLFHDHDELAAIAEAQSEALGYPVEVGFDALVVRARTTGATDEREMIGIR
KDGRRISVRISVTVMCDAQGELAGYLGTLIDMTEHKEAEASIQRLAHFDSLTGLPNRTLL
NERVRHDLARAHRGHESLALIFLDLDRFKNVNDSLGHRIGDDLLVQLAGRLKRAVRDDDT
VSRLGGDEFVLLLPNTDADGAAHVATKLLEVTAPPYCIEQHELVCTVSLGIALYPADGDT
FEALSRCADTAMYRAKQRGRNAYCFFTAEMQERSTRMLQIENELRRAVVHGELRLHYQPQ
FALVGRRRLIGAEALLRWQHPELGMISPAEFIPIAEECGLILSIGEWVLRTAVLQMRLWQ
QAGLPPITVAVNLSAVQFRQANLTEWVSRILDEEELPAEYLELELTESVAMDNPLAAIET
MDRLRRRGVRMSIDDFGTGYSSMSYLKRFRVHKLKIDRSFVADLAADPDDAAIVAATIGL
AHNLGLQTIAEGVESEAQLAFLCAKGCDEGQGYLFSPPLPAPQFEAFVRDGWLV
>A0A1V5PYH3|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MDTSNERFNPADGSGLLGETPEKSVTGESKTYGISDIFPDNIPDSVPGITATVGRDIQGG
ADDFFGEDLINNIFEISNELYLKMRDPATSAEEDHLTIISLLTDLGRRLVNADRASFWRQ
DKEKGTIWTMSATGTGKIEIPIGTGMVGKALKEGRSLVTNDPYNDPFFNAEVDKITGYIT
KSILVMPVTNSRGEYIGAYQVINKLDGDGKFNIRRDCKRLSLAAFICSITLESDLFLADA
ERDRLTKVRNRIGFYHDFSMRYGDGIDRRNNVVGSMIMCDIDHFKAVNDTYGHNAGDAVL
RHVAAIAAGSLRRTDTVYRWGGEEFIVLLNDTGIEGAVATAEKIRAAVEESECIFDGTAI
SVTLSFGCGDIDPARSAEENIAVCDRRLYIAKESGRNRVVREG
>A0A549TY07|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
MIRRTQEIDVILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDISGDDSHAVCQFGQWLKD
HPQHDDDECSYVSNIHATHEKMHLLGKELLLAIVEDRSHSWHFDSFQDALLGFTSAVMDY
KIYLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDMVLRSLASNLLAWTRYDEVAYRYGGEEFIVIIRTKTDEQACQAGLRLCHLIGQKKIPY
PEGEIGITVTAGITRVQQGETLDNGLGRADRAMYEGKQTGRNRCMFMDEKEKITLVGTND
QLTPRVRA
>A0A380E2Y3|diguanylate cyclase|EC 2.7.7.65|Staphylococcus aureus|TrEMBL
MTIVSLLLSVYPIPYREDYLIHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIM
YGVTLIVIAAVTSAIGPFLKQNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPIS
LIITLASAITFVDIWHFFSLVNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSI
ALLLIDIDGFKDVNDTYSHKSGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSL
DQSVKLAENIRSGVEKSSFHLPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVA
KNQGRNKVMFNPIINL
>A0A7Y2LUE2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5414|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLVLVEEFYKKMLVEKESAEFFSDD
LIQQRLLNTLNAWLLESFSVGINKRYSEAVQKQHKVGHVHARVGIPSWLIMRGICEIERK
VFELVAQNQQQDMITVCSYIVQIMGFASEIMCRSYEFNLEKNNDIKHTYRLFSAMQDVAS
QKDKQRSSLLNWENELMFKVFSDELKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVSVIID
RIYQIDLLSQQVLNAIEKDKAIQLIQDIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNTPLSLLAIDADFFKRINDKFGHAAGDLALQFIGEVLLESV
QGSDYAFRVGGEEFLLLLVDSDLGRAQEIAENIRRRIQETTIRTTMGSSFNFTVSIGCAL
YDGHPDYQKFLDTADTALYAAKNSGRNRVYLAQNELQVAVVANTPESVQL
>A0A0T9V1H9|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MLVTGLDVLNILSTPIWVVLPKNQEILFANKEARKLAGDVLLSVLRNGRFSAHAQEHLDS
YLLPLAVGDQIIEIWTIQTEQSVFPLSCRLSLTQLDPYGAVIIFEGLGEPVPAQPTDERL
LTKAYSRSERSFYEQFFSTNTAPMLLIDPSREGQIVDANQAATRFYGYSREEMCMKHTWE
INSMGRDILPVMNEIAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCIIHD
ITEQKRLEQALEHAALKDPLTDLGNRRQFFPLVEHAHAQSQRYGQNFSLILLDVDHFKNI
NDQLGHHKGDEVLIFLARTLESIIRECDIVFRWGGEEFAILLPLTNLEGALQLAESIRET
IQMICQPNLPQLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A0T9TKD2|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MSSIKNESAEQIKNQTHATRLPTLGRVLGRIHLIVALVSVATAGIFLTLVALFALRVYAD
HNLHLIARSISYTTEAAVVFGDTVVANEALSMIAANEEVAEAKIMDVNGRVVAQWTLPDD
GPMHQMEQSVARWALPEPVVLPIVHSGNEIGRIVIVGHGGSLLRFLLQGLAGLFVCLILS
TAVAIFLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAYFEGRLSRTLSDCKTNEHVAVLFLDGDRF
KEINDNYGHAAGDTVLTTIADRLRALLRESDLVARLGGDEFAILLAPIHNAGDVLIIADN
IIRSMTQPITLPDGSQIITSLSIGIAIYPDHAQTPDELLQRADEAMYQAKKGFRPCEQGT
VYQSDYIHAESTHTNLG
>A0A450CRH6|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNRINKKIDLLILALLVFIFLIVGIVILSIRTENKLNVFIMLAIIFFIIMLTYLSNSVVG
LITSSIIIFMYTSYILYNNITHNMDVEFISYMWIIAIPISSIIMGNLNKSINELQNTNKK
LSEQYKELVTIDSETGLRNLKIFYNDVNMEISKSIRHNTDFSLMIVKLPYYGNLQTIFGE
NKTNKIVKYIGSNIIECTRNEDIIYSLQKDMIGILMPNTSLEGSKVVKDRIKKRIKELNL
DLNNRGKYVNIDVKIAFLQYKSSFGDSINFKNTVEEELQYDV
>A0A8B0SHD8|diguanylate cyclase|EC 2.7.7.65|Thiothrix fructosivorans|TrEMBL
MRFVVPILSSIAVALACVWVLSSGQLSKLFMTDALSGLTETVPHLLLAILAAQVGAVYLL
KRTALIASRTSLPDVNITPNTEELLAMQDQVNTEWVLDALAGGVIVANQQGNITYMNTSA
EKLTLWSRDKVLGEHISKVLKLDDLQGNSIEIKAFETNLTHPNHPLQFGQVKLHPRVGEE
RFVELNTTCILEQCKAIVFIFRDVTADRKVINRLYRQASRDALTDLMNRTSFEQYVEQLA
HDTSALTRSHVLASVDLDNFKIINDTCGHLAGDELLKQVAQIFRRAVRTSDKVARIGGDE
FAVFLEGCGLEKGRSIMESILTELRNFRFSWEGKVFTIGASVGLLEFMPASTLQIKQLFS
DADKACYTAKALGRNQVFVHEEEKREAMSNQRVHDWGKLLKDAIREDRFILFAQPVVPLH
SERTQRFRQYEILLRLPFRQALLNPGSFLPVADRLDLMTSIDRWIIRKSLEAQYVFQGLV
FLGIANVTDSGKVSHFR
>A0A8F5IG70|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MNDRIFTPEHGRGPRPCVHWLVRQNRRHRTWFFPLIAAMIGAQLHDLDAAASSWLFLALH
FFVYPQLVYLRTTRPKSPAGQRDVELRWMVLDNVLYGLWFAALGFPLWICYVISLAGVMS
LVAYHGLSGVVRAVPAQLAGAALGVPLFGPLVWHVQTGVLVTALCMGSFVLFSLMYAYDA
YVRARRLKDSRQVARNQVDEIRLLQTQLRAEALCDPLTGLHNRRHLSEALPGALARCARL
KLPLTLVMIDIDHFKRVNDTHGHAAGDTMLQALARLLQGHVRQGDTVCRMGGEEFLLVLE
NAALEPAWQRTQALRLAFADLAVVHDGSSLRATISCGLATFPEDGGDAPSLLQAADRALY
AAKEAGRNRLQAARPCV
>A0A381I5A8|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MLILFIQIKVTYKISTIKNIFYSLNCSIIGLAINIFFRSLMSIVLNMPAYLFDSNSIANI
YRVFPISFSFIVTGLYFSYKNNKNNKINFEAVLEDKKNLIFLLSLMFGMYLYLCLSLSIY
YTVGNVLILKLYGIKSAIIVLVGNYIAERYSFRITQIKGYDIKNQIEYVESVKTEYEINK
LNDIVYTDLLTGFYNRPFVNQKLSEWTSNHYKFTLCFTDLNSLKPVNDKFGHQFGDKYIS
TTAQIIKKLINVENSLLFRYGGDEFLFLLQNTSCVEAEKIMININYELSKLSNTDEYPYA
LSISYGLVEWDGISDIETLISKADSLMYENKLKNKSTLN
>A0A8J7X449|diguanylate cyclase|EC 2.7.7.65|Silanimonas sp|TrEMBL
MERTSPPRHRLIEAAARALVDPVFVLDREGRYLEVFGGTDREAYDSPDYLVGKTLHELMA
PKLADVFLDTLRRVLDSRRPRIREFRLSAADFAGNRNDGPKGEQWFEARIAPVHADADEL
PECVVWTVINISQRKQLEAELQRLATRDELTGMLNRRAFLATLEAAMRQAQADAAPLVLA
ILDLDYFKTVNDRFGHMVGDAVLRHLSERLLRSADGALLGRLGGEEFGVLFTRSGVDAAM
TVLRAMQQSCEEEPFHLGDTPVPMSFSAGVAALQPEQDEQPSDLLRRADHSMYRAKNAGR
GHVVGPDCTLAPAQVASASVVLSADD
>A0A174HLV4|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKLKWRGLQFEHYILGILLAVEWIMSFTFLGYIHIPPISITTAHIPIVVIACLFGPVESS
VAGLFFGLGSMYKASALYVMLGDRIFSPFQTDFPIGSILLSVGTRVLFGFLMGCIFKIVN
KSRYKWAGKSLAALIATPLHALLVYGAMGILFPESGFNYKSSFRWGVNDYAIAAICILAV
ILSDIIYHSSFVTHYKNVINDSELRQHWSVKMKMSLFIIIIFVFCIAAFSTIYFASRTEY
MFGVYGVKVTKKIAQDILHLQVQFLAAMISLNFILLVIILMIYNYMKHREYMGEMDALTN
VMGRRLFLNYCTKCQNDRDDIDNKSKRKGWFLFIDIDWFKQINDTLGHTVGDETLKQIAE
SLKNIFSSYGAVGRVGGDEFAVIINEKMTKEQLEEQLKKFLLDISAILPERTVSCSIGVY
HFGFPKSQKELLTRTDDALYKAKEKGRACYVILDE
>S3IRJ1|diguanylate cyclase|EC 2.7.7.65|Cedecea davisae DSM 4568|TrEMBL
MHNTRLLRPERRKKRNGWFEKIAARFVRQGAPTLIGNAFERFLSRYKRPQRVVNICFIAV
LLFSTVLTWREVSVLESAYVSNQRNSLDNIATALDRQLQHSIDNLLFYRNTMHYAMQSPI
STDISRKLLANFDIERTQPYWQLRLDINRSMPINGISDESVSRSPLLKRDEALLHPELAA
ALEFSYIIQLADGKRDLQRRVFYASRAGFFLSSTPPENDPGIVALYHRLIDQPYFAAQSP
QNNPRRCVQWTHTFNPSSQSGQIITAALPLDFEQRWYGVLAMDFPIEAMHQFLQNSSRDR
YEGTVMLFDKQFNLIATGADKVPAGPLFDDKQQAEIARSMADGQEGELRMDTRFVTWARL
TNFDGVLIKVHTLDEGVRGEFGRISIVLTVLWMLFTLMLYISWRVIRRLVNSMLALQETL
SWRANYDTLTRIYNRGAFFETARALASDCQRRQEPFSVIQMDLDFFKGINDRYGHIAGDK
VLAHAAALLSSALREEDVAGRVGGEEFCVVLPGANLAAAAGVAERIRVRINNKELLLMAG
QSIKISASFGVSCAHERHDYDFEHLQSIADGRLYKAKQNGRNQVCAADSSAGPDSSGV
>A0A151B2C4|diguanylate cyclase|EC 2.7.7.65|Clostridium tepidiprofundi DSM 19306|TrEMBL
MAYNEKLLHEYKKIKEEFINYQNFTESTIQMLSDKNSKLEKKLNVMANIVEISKYINLNL
SNDNLANVINDMIIGILGVAYSTIYISENSDWVVKATNISHEDFALHQEFHFNPLKKNNP
FILNLGDTYDNNNLVALTGIHSVSGVPINIRDNELGFIVVEHNLMYFFDVEHIKFLSSIA
NQIGIALENNSLYKKVKDMSIKDSFLGIYNRKYFFDTVEKFISENPKQVFGIVMVDLDDF
KKHNDKYGHLFGDYVLMNVTDIIKRNISSEDILARYGGEEIIIYLNDIKSSDEAFDKIEK
IRREISETVFEYGNNASKITASFGIGFYPYNGLSLEEVINASDNMLYKAKEMGKNKVVCA
>A0A1S7SDU6|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. NCPPB 925|TrEMBL
MRAAVAVPYHSGIRLHLLFEKNARMSETIDTNVFNLAPVAMWIEDFSAVKSQFDIWRADG
VEDIRAFLLEDLSRVAACSQKIRVIAVNAKTLELFEARDQAHLVDNLHRIFRDDMLESHV
NELSELWAGRTEFTSNAVNYSIGGRRLDIQLRGAVIPGHEDTLGRLLLTTEDVTEREEAR
RKELLNRRYAEGMFKHSPVSLWVEDFSRVRRLIEEVRDRGIVDFRVFMDVHPEFVRQCMS
EIRVIDVNRATLDLFCAPDRQVLLQRLGDIFRGEMEKPFREQLIELWNGNLTHHREVVNY
ALDGSERHVLLHFSVFPGHERDWSLVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAF
YSDELNRLERSALRPVSAIVIDLNGLKDANDKLGHDAGDALLRRMGEVLNGVVTAPNHAA
RIGGDEFAILLPGADKQVAAAMVETVYELLKINNQFYSSAPLSLSLGVATSEAGEAMESL
VRRADMNMYEQKNAYYAALRNRSADNSDTTKSGAQPETTSLKRLF
>A0A318VY79|diguanylate cyclase|EC 2.7.7.65|Thioalkalivibrio sp. ALE21|TrEMBL
MSEGEPAGAVAQQLVDEWQRRLERCPGPVRGRVRELAEQHRASLAERFYAEMLADPDACV
FLDHEDVNSRLNASLQEWIRGIFSVESGSGVEEQAARQAHVGGIHARISIPIHLVMRGAR
CVKEQFLTLLELDSAMGHEMRLQAARHVSDSIDMAMELMSHAYSRSHERNARAEEAYRLF
AVSENLASEKDRQRACLLDWENGLMFDLAMGASGDQLPRLSASEFGLWFRHKGVDAFGGA
AETERVLEAIARIDEFLLPSLVCVEARQRQDYLRDVREQVRSIDYHLGQLFERSNELESG
RDVLTRTLNRKFLPVVLGRHIASVQQTHAPFAVLALDIDYFKRVNDEHGHETGDRILQQF
ATLLVSNSRAGDYLFRLGGEEFLMMLVDVVPRDAERIAEKLRTAVRAEPFQGAHGQQLGL
TVSIGLASHDGHPDYQRLVRRADDALYAAKNSGRDQVAVAD
>A0A0J2K3L2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHEPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A1V6ANB7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MNDNEKRIKALEEKLLEIMTINQQLIEEKQQDTNLNYSWTGNLGKWYWYVPTNKVTFNHL
KITALGYSESEIPEEVTYQYFTDKLHPDDYEQCMQIMRDHLNGKIPVYDVEYRIKAKDGS
YRYYYDRGKITKYDKDNNPVLLAGIVFDITEKKKLEEQLAEQNKLLYTLSFTDGLTKVKN
HRALIKILEDTAIDANNNNETFSIALFDLDNFKKVNDTKGHVCGDMVLENIAKIMMESVR
KSDTVGRYGGEEFMIIFPNTKKEDAFKITESIRGKIEKYRFPCDVLATISAGVCEYDGTS
TIELIRKADTLLYKAKDNGRNRVESL
>A0A379TLB3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLITMTLIWLLICVASVLTLKQYAQKNLGLTAATIAH
SLEAALVFSDNAAAAETLAIPGRQGQFSAAEARDKNGRIIASWRYDAQAADDKLIGLISH
WLFPLPVSQPIWHNGRTIGEVRLVVRDSLISHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDQRIEEFHLFAQYFNSLLDEMEEWQLRLKAKN
AQLLRPLCTIR
>A0A7H4NT33|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MARHNRKLSFTTPIIIGFAGILFSFLLIAVFATTTQRNDFLEDYHHINRNFTHNMATNYT
ETLLQGNDFILTRAATFFARNDALNEAVNVNPEKGLMQLMQLQNMMQTVSSISLADTNGH
YLRAPEVLETEDSQSFDAKTRPWFIKQAEASTFSRYTSPYNDYFTHHPTITVYKPIISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVILHPDPGALFKPYVSEALMD
RMTSGEGQLYDTNTDTWYYYYSFTNPDWFVIYRVDNSTLVNLTRHETDIVAWSFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAVIFTTGHSDDALMLLESWRARVAQRSWREEGLTVTFSAGLGEW
NMEPLEQLVVRVDEALYKAKQQGKNRIVRA
>A0A2X4W632|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MKDNSACSSSALLFLDGDNFKYINDTWGHAAGELVLIEVAKRLAEFAGNRYQTYRLGGDE
FAMVLYGVHSEYEVQRICAALSQLFNRPFELHNGQRITISLSIVFALT
>A0A379S953|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MCGTSANSAIAALSRVHERLNALRLPGAPLVMLRISVGVAPLTPQIGHYRGWLKSADMAL
YKAKNAGRNRTEVAA
>A0A379S374|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MLFSTLLTWREAIILKDAYVASQRNHLGSVANALDRQLQFNMDRLIFLRNGMHEALVVPL
TFSALQSAVMQFEQRRARRFWQLELDKRRTLPLYGVSDQFVARTTLLSRDNSDLANELTA
TLELGYLARLARSSAMLTLEAMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQ
RRNPQRGVRWFTSTRPYFSDEQQKVTASLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEK
DIEGEYQLYDNRLRLLADSTPEQQTANMLNDRERTLLAHEIEKDTEGGLRLGTRYVSWER
LDHFDGVLLRVHTFREGIQGNFGSISIALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSS
LQWQAWHDPLTRLYNRGALFEKASRLAQRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGD
RVLSHAAGLIGSTIRSHDIAGRVGGEEFCIVLPDATKAQALQIAERIRQRINDKEILVTK
STTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYAKQSGRNRICDRGATQEWEKK
>A0A379SGU9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNDENFYRKALEEAVAPADPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVSQHVS
GGWWLLLVGWSFVWPNLAWQWATKAPDPLQQEIYNLKADAILTGMWSALIGVNMLPAAAL
FMMMSMNLIGAGGLRLFFAGMGLFLASCLATLQLTGLPIAMRSSSLEVTLSLPVMVLYPL
LFA
>A0A379SVU8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTTEKRRAFCDAFETINGTHGVNLIRHNYPALHGTLQTAATQCTDN
IDDVFLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLKKHYVYFYDLINSQRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLSGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNITLKDLDSGKEIIINKSKNNLFQYVDYNHDIPGGLRVS
FSLDLTYFIVSSWKALAFYLLATALLLNMVRMHFRLYRDVTRENISDAMTGLYNRKILTP
ILEQRLQRLVNTGTPVTFIAIDCDKLKLINDTLGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIVRNLQIIAPDKSVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKTASFIIVFRSKNQFSCRTRSEK
>A0A8G1DZK1|diguanylate cyclase|EC 2.7.7.65|Leptospira interrogans serovar Bataviae|TrEMBL
MNVYQQNESRIQKKKILMVLAVIPILMIGTFVYEVKQIQSEIHRVVWMRARVTQDYIRRI
SNQTRALKLSISHSMDYYEDSILDKRVLHKFKKYSSLKIFGNKNQIKTNSSTSEFLATSA
SITPFFLREVEAALGLGGQFETLVETETQSEVVWAYYLSAQKFLYFAPTLKPYKDIFNEG
LYQRPFWVQATPKTNPQRKQVISELYNDIGGQGLMITISEPVYFRDQFIGVAAIDIGLDA
MRRVLAVGDCIGESILIDENNKIIAKESWIDINDSTIQLPSGPSEKIFLQEGYYWAFFEI
KDQEVRLVHRISAVEFLFSVILNLLPFWGLICTLGIVSILYIKLKASMEQVSKMIHTDPL
TGIANRRGFLKLTQKSLVTIHRHGQSWTILMIDIDHFKQVNDRFGHDTGDRILIKVSQIL
SANIRQTDVVCRWGGEEFAVFLFGVTPEDSINIAEHLRKEVESKVVLKDGKPVTLSIGIS
EGKSGKSSGSGLENAFACADQALYQAKTLGRNRVCVFDTTTEMF
>A0A2K8L3M4|diguanylate cyclase|EC 2.7.7.65|Mariprofundus aestuarium|TrEMBL
MADQKINAGIGVPAKAPFRVLLVDDQAIIFEAVRRMLSAANDIELHYCGEGAKALQMASE
VKPDVILQDLIMPDVDGLMLVKFYRANAATTEIPVVVLSSKEEAKTKAEAFHCGANDYLV
KLPDQIEMLARLRYHAKTHKTLLERNAAVEELKRISLTDGLTKINNRRHFDMTLLGEFKR
ARREKSSLAVVMLDVDHFKQFNDNYGHQAGDECLVQVAEALQSSISRPADMVARYGGEEF
VAILPDTSREGMLHVAEKIRQAVFNLQIPHEYSSVESVVTVSLGVAQMMPAPEAEDSQVE
LLIKLADQGLYEAKESGRNRIAGVN
>A0A011NQ56|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MTDDLLRWADDAADADVRPATALLPWKILVIDDDPEVHTVTRFALLDLRLFGRPLHLLHA
SSAAAARALLRDNLDVAVVLLDVVMETAQAGLDLVGFIRDELGLAECRLILRTGEPGYAP
ELTVIQEYDINDYRTKGELTHTRLITTVSSALRSYQQLHALAEHRRGLELIVRAAADLMQ
EHAIANLAEGVLTQLAALLRLPVDGIVCSQKGSPLGDDRERCYVVGATGRHAGCIAQPLE
TLADQRIVAAIMSSVARRRHLFGVDYAVLYLQAAPTQEAAIFLEGGQMLETIDRTLLDVF
VANIAACFRNVKLVERLLRAQDEIEAQRAFLRTVIDASPHFIFVVDREGRIRLANQSLAE
RFRQTPAQMVGRLQADFVSDAQLLQALQGDDEAIAAGRQERIEREIGFIGRSGEERWFHT
IKVPLKNAGGAVEQLVGVSIDVTDRKRAERRLLEAKERVQVTLDSIGDAVITTDAEGRID
YMNPVAESLTGWAVAEARGRPTADVFRVLHEETRVPARDPIQRCLAEKRIVSLPGHCVLL
ARDGREYDINDSAAPIPRADGGLQGVVLVFHNVTETRQLARQLAHDATHDALTGLINRAE
FERRLERAVSSAQDEGARHVLCYIDLDQFKVVNDTAGHAAGDELLKQINALLAGSFRESD
TLARIGGDEFALLQENCPLERGHVVAQAALRTLRQHSFSWEGRSYQVGASIGLVPITAET
QDTAELLTRADVACYTAKELGRNRVHVYQSGDTETVQRHSELLGAAGLRDALERGLFRLH
YQPIVGLAGSEFRIVRYEALLRVVHEVDPGRQGELVLPAVFIPAAERFGLMGAIDRWVIR
RAFQEYAQGIGTTGATLAINLSGNSLSDETLLQFIEAQLAEFSFPAERACFEITETAAIQ
NLRPALGVMAALKRHGCQLALDDFGSGLSSFHYLKTLPVDFLKIDGSFVKDMCSSAHDEA
LVAAINQMSHALGLRTIAEYVENREIVDRLCQLGVDYAQGYFFGKPEPWRQGGD
>A0A378Z7A1|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MKSTISRTEQGNRVAATVILIACAALTLAGFLTRAFEGAVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTRAPFWLALVAEA
SFAAYVMLSVRSYARTRSDPHTRPGYSEAARYGATVLIVWVTVSLSLVGAGRTLVTPHLA
GGVDIETLAIGALFLAYAALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPSESS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRLVAERVQQRSIPLSVLLIDIDYFKQVNDRYGHPFGDAVLQRIANTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKARDDGEFITISVGIASWEP
GEPLIISSMLEHADQALYQAKHKGRDQSVLGGGQMAA
>A0A2X2W7Q5|diguanylate cyclase|EC 2.7.7.65|Clostridium cochlearium|TrEMBL
MDKILFDTLNYVNEGIIILNDKLEIIFWNKYIEYITGIKEEKVINTTIFEAVPSLNKCYF
RKAVKFVIEKDHKFFFSSTMHKGLISQNGEFNLRLNRIGDCNSNYLIIECIDVTSQYMRI
NELKGYVSKLCLLNKKLKEKEKEIEKLAYYDKLTGVANRTLFYNCAEKFLDSAKEENKIL
GLMFIDVDNFKCINDIYGHKIGDKVIVEVAKLLAKCTRKSDIVARYGGDEFLILLPDIKD
YSNYEIISLRIANAINKVNIKDIDINISLSIGTSFYPRDGENIDELISKADKAMYNVKNL
GGNRCAHY
>A0A543Q7U9|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MTHKNPSEIAREALKRLMELDLSPTPENYTQYYHEISGTHNTPEINWQHLMRRFCTEWER
SQAGLSHLQKILAKNQLLDEKNTGTLAIKLEQLLQKWEKLPTRQATISSDEINENDGDDV
NCVLWQKLFRTVIRHSIREQDQPSALLLEQMDGLLNEKEIQADALFPLARDLLHHQQELH
EKETKIRKGLQELLQQLLRNVADLLDNDAFLSGQMDVVRQAVQIADNHEELDLAISRAKE
VIFQQGKLKSEVREAREAIRDLVNLVLVSVESMAGENGRNHQQLESLANELDSAADWQQI
RKIVNEVLNTSKNITKQSIEARDTLLQAKNRLSAAQEKIRKLEEEMESISQLVHVDPLTG
ALNRRGMSAAFDRESARTQRLNQPLIVAIIDLDHFKQINDRYGHDLGDQVLQGVVKIMQD
TLRANDVITRYGGEEFVILMPDTTPKNALDILERVQTRLNRQSYQTQDQPLKISFSGGIV
LWQNSCSLEQSIAVADDAMYHAKTDGRQRIYLADQANSST
>A0A543Q7W5|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MLIETFLPQLEKGNCPSPSQSTLALMELLQKEDASLDEAAQLIRLDPILVAKTIKLANSP
IYRPTRPIISLDEALMRIGLQVVVRMALGLALINGKLSDTPDFDLNHFWSASLLRAIAMQ
ALAKEIGNWPAGEIFIFGLLSEIGSLMMVCTAPEKSTIFSNKGLSFAEQQILEKNEFGFS
RHDLTAALMRQWRLPETMVMAIENCNSGIDFDLEHASNSSSDRLQTLISILGSGRSITEW
AMSPASDRSLEVLQENIQSWWMNTPHFVAMIHHILFEWTDIAEIFELPQSPPGLENLESI
RNTLMRLREDHEDIRNKPLLLVDDQAGDRALLQRTLEPAGYQTLQASTADEAFTIIYKNS
PRIILLDWVMPVINGLDLCRRLRREFGPRLYIIILTAHYNQSYAVEALQAGANDYLSKPI
PRSVLLAKLAVAQQIVEFISSLESNCEKLIHQNNSLQSMAMKDALTGLANRRGADEFLKQ
HWSNALRSQSILSCIMIDIDYFKQINDQHGHDQGDLVLEALGKLLLETSRVGDLTARVGG
EEFMIICLQCQLADAAALAERIRHKAMSLSDKLPPITISAGIAELSENMINSEALLRAAD
QALLVAKRNGRNQVVCAPKDTGGAAL
>A0A554WQT6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MHHPLRPPPTPHAAPAANANATGWAALWGRVRADYTLGVLVLGVLVAVVWLLPFAVYRAW
QGNWVAMANDLVLSVLLSAAAGYAWRTGDTRAPGWVVALAIVGGIWAIGVAARFAALFWT
YPGVLMLFFLVPPRAAMLLGALAVAGAAGLSWSELGGSEGLPFFVFTALLTALLGYVVAQ
QAQRHIAAWRTLSLLDALTGVGNRRLLELELAQAARGASVGALVVVDLDHFKAINDRLGH
DGGDAVLRQFASVAQAVLRKTDRLYRLGGEEFVLWLPHGERGAVQALLERLRVAVTERVR
AGEVPVTFSAGVALHVAGEPWAACLARADAALYRAKRAGRDRIEWPAADAGVPART
>A0A8F8E591|diguanylate cyclase|EC 2.7.7.65|Caulobacter vibrioides|TrEMBL
MSDVETTLRGPEAYKIASRALELMERHQVWPTALNFELWTHYVADPNGALARELTRLISL
GEPMTELVSEELAATFLPKARLNEQIRDAGDILSKELEAVSKAIQNAQKSNAAFGQELAG
ASKSLDTHTDVASIKAVVGSIAEATRRVHKENQSLEARLADSTAEVERLREHLEQVRRDA
TTDGLTNLANRKAFDDELDRACAEAEEGGTTICLAVLDIDHFKGFNDTWGHQTGDQVIRY
VASVIGRVAAPPRFAARYGGEEFAMIFPREAASVVATTLEEIRVEVSSRMLKRRSTNEDL
GAITVSSGFAERKPGESGHSVMERADAALYASKRGGRNRVTAAESMPGAANAA
>G2D9D7|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MRDMERENRHLKQRLKELSNEARRNETTLNRFHQRELELLSAGSLAELLQHLTDGMRRSM
ELASICLLLEDRKHHLRDLLNNNGIPAESFPAVRLVDDLQQAHPHLTSLQRVWLGPFLVP
EHAGLFDNPQQLQSVALLPIPRRGKIIGWICMGSRRHDRFTRHHASDFIEHLATVSGVCL
ENAANRERLLLSGFTDPLTELYNRRYLDRRLPQELSRSHRYHQPLSCLFVDADHFKQIND
QHGHSAGDQVLQELARRLREQLRASDLAIRYGGEEFTLLLPHTTLEEALRLAERIRQRVE
REPVRLESGQTIPIRVSVGAAQSLPPPPDLQPDLESIAKALLENADQALYLAKSNGRNRV
ECINPQARG
>A0A8G1D6T3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MSTPGVPVKRLGLLGDELSAWGVALAALVAGALLTAALAIATQTFYQQQLRQRFELLASE
RYSRIAERFEEQEQRLDGLRRFFAYSTEITPREFDGYARPLLHRTQAYSWAPRVAAAQRE
DFERRASAWLGQPYRIRDVDAQGDWQAAPARDHYYPVLYTQATSRQAQPYGFDLGGQPLR
AATLARAVSPGSMAVSAPLDMINVEPTYTRGLLIVAPVFAEQASAGEPPRGYVMALLSLH
QLIAESLPTVADDNLVVRILDLSTEGGHEVLFDSGMPPARMGFASSHLLHLADHHYQLDI
RPSQGFLAANRSSAVPVVALLGGLLSVLLALLLYSLFSQRQRALGLVARRTAELRVSEQS
LRETHNQLRSVLDAATQVAIIATSLRGVIGTFNAGAERMLGYSAGEALGQLRLEDLVLPE
ELHQRAHALSVRFGREVGAGQAMFAETVQEGGAEPADWTLVRKDGSHLLANMLVTAVLDE
QGLWVGYLAICIDVTERRRVHEALAARDRLLEKLSAEVPGGIYQYRLDADGHSCFPYASQ
GLHDIYEVDLALLRQDAAAVFERIHPDDLERVRRSVRYSAEYLTPWREEYRVCLPRAGLR
WVRGEATPEIGEHGSTLWHGYLTDISDLKRVEEELRALSVTDALTGIYNRRYFQERLRNE
LDRAQRDGLDLAVIMLDIDHFKRINDQYGHAVGDHVLRSLCQRIGQRLRRTDVFCRLGGE
EFMVLCPGSNAEQARMLAQELWQGVRSVPVEGVGRVTASFGVAGWRVGEGADALLLRADA
GVYVAKQGGRDRVEGELS
>G2DH51|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MAERPERFFIAVLDLNLPDAADGEVVDYVSQFDIPIIVLTGNLDTSARQRMRQDHLVDYV
LKRNASEIDYVCNLVRQIRDNYRRKVLVVDDSRSFRLYLRGLLSVHKYQLLEAANGKQAL
QQLKANPDTVLVISDYNMPGMDGAELIEIIRRDHRREELAIIGISDRTKAQVSARLLKAG
ANDFITKPFEVEEFYCRVMQSVDMIARVCQIRNAARRDFLTGVYNRSYLYEQGEEMYARA
KKSAAGLAVAMVDADHFKRINDRYGHQAGDAALVAIANSLQQSLGEACVVGRYGGEEFVC
LLPGASESLAMQQFERVRAGIEALSIQNGGDSFQVTVSIGVTLDPGESLEQMITRADQGL
YQAKAAGRNRVELN
>A0A517W4Z2|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MRNYYAAIQFWSYALLVVCLCPLAVLLGTYMDWPLGAAPLLLLTLPTILAAVSSPRICYW
TITALAVCACFAEILFRTDISEVNTTYLFSILSAAVLVGMTLLIDLYIGKLRGTISQFDA
QNDELVRRLYESQKEPTSGFDNISSDSETEPDETSDTDSAEKDVNYPLLLLTLQDIGRRI
STNQSNESLIPTVISTAKASLQCEHCQVYLWDSKVRALKNPLPARSRDKLDYRPDPNQGV
AAWVIENRQIVMRNDADQDYRLKRILEEDPHMPDAIAPLTVGSELIGLLIIDKVDLDSPT
IGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLFNHATFQEKLQQLTKTADAQSTT
LSIIMSDIDHFKSFNDTFGHQAGDFVLKEVARIWKTVMPENAIVARYGGEEFIGVLIDHE
YSQAMQIAEDLRETLENCPILFEGQQLQVTASFGVTEYKHPASNTNEFVRIADEYLYKAK
ENGRNRVVGMAPNSTRKPSS
>A0A1V0LG07|diguanylate cyclase|EC 2.7.7.65|Kosakonia radicincitans DSM 16656|TrEMBL
METYLKNMKAEWVNLLERTDEHIRLIAADVGKNHARLLSQEFYTVVLTDSQAAEFLSNEQ
VERQLKAALARWIAEVLACQIDDVERLIEVQQTIAAVHARIGISVELVEMGFRVLKKLLY
PVINSADYAPAEKLQVYHFTINSIDLAMEVMSRAFSFTEHNASKEDENYRIFSLLENAEE
EKERQIASLLAWEIDLVYRIVLDADLGNSLSLSQADFGLWFNHKGRHYFSGIAEAGHISR
LIQDIDEVFRNTRETTKALSNRSLRTKFLIQLRKNVSQISTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAQAKRASTSLSVLVIDVDKFKQINDTWGHHTGDEILRKVSAAF
YDNVRSNDYVFRYGGDEFVIVLTEASEFDTTRIAERIRSRVEKTVIKSPDGQTIPLSLSI
GAAMFSGHPDYERLIQAADEALYIAKKRGRNRVELWKPAP
>A0A0K9T7S6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M114|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAS
>A0A1C5MH10|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEFLDSEMMKRFMRSAPVNIFFKDTECRYCFASEICNLVSVGKNGSIVGKTDLEIQKFPE
MGKMFYEDDKKILATGKGSQYISEFPMENGESLYFEIKKSAVRDENGNIIGIVGIVDNVS
ERVRLEKKVEELSIIDGLTGVYNRNYLNYRIEEKKKNLTFPFTVIMSDCNYLKKVNDQFG
HEYGDILLKIIAGTLKEEMPEDSPVIRMGGDEFMILGNGIAEEKASELMENIRESLKRKS
KEKIPLSLAMGSYTVQSKDFSFDEVCHEADLRMYADKKRLKADESTEITE
>A0A6N2X376|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEKEQGKLIIIVSVVFAMVLLCMICTSGSVPEVKSLRACTPEAVSVLDDGRELYDFILDQ
NDDETNSIVFYSTHQEIVVYADGKLIYQLDAVPGIWGNTPGWTWNIVRFSSNVSSLQVQF
TPCYPETAGQQKTFYIDGGYNIYRWVMRRTMPAFLISMMVILIGLYISIYWIVIRCGSRI
DGTLLYLGIFSILLGTWSANETDVATLLLTNRQGCSYLAFATLMLLPMSFILFVKSFLEI
RDDRFCRIICNANLALIVLTHILNATEIYEFRRSLWMTHALIILMILYLLVVICSKIARR
QLDQRLKACVGALLLVFFATIVDVSGYYKTSNDVGVFGRISFLIFIVVLGIESARQTVAR
LKKGRRVEELEQFALNDSMTGMYNRNAYDYFVKNEKDFEGYVIVTFDLNNLKQCNDQYGH
RAGDEYIINAAHIIEDNFERYGKCYRIGGDEFCCIIPKGRYFKIERVMHKIDQDVEILNH
KNIIPVPVGIAYGYAVFTEDDTDPEKVRERADEDMYRNKKAMKQS
>A0A6N2WT07|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRINSVEQKGYANRIMDWKIFVRQDLVVAKASEFFYEFVGENSFRPVSELLLPEDGELLK
KAVEADTFQPLELITVLHNLKDSVRNVYLRLEQSEQTENGIPLYQITVSDIHDLENRNLR
LEQSILKYRHFMTLEDVYFFEYLIEQDSITVYKYVNERAMNQFEGPMNALIRNVEQAHEG
SDIAILEGQLRTFCAHLRNGDDFFEMEFVSEQEDKGIWRVKGSRIPKKRDMVAGIITPDR
NREQEAYYLTPAARDAGTGLLNKRAWTEYTIEQLNRKDGQVRWLVIIDIDDFKHINDTYG
HIFGDQVIRRVAEIMQELVGQRGVIGRFGGDEYVILLEKVETREQLKTLLKTIAKEFALA
FDPKTHATASIGVSEYPVDGSEYEELMRKADKALYLAKEKGKNRHIIYEERLHGKLESDD
MQNMAMAYAVSKEKKREVITKMITELCVSDVNSIVKKEERLQQIRSLFDLDGITIYSESG
AQLVCRNGNYMVEVPDGRGLFEDEKYLALFGDDDNFIESNTLKLRSQDPAAFAVMQKQEI
GAFLQCLCRKEGVPNVIVNYDVFNRNRKWSDEDITLLTILGHCIGNLLNYSE
>A0A1C5MK46|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MELKKRGKLHYGEHNKKESMKKRKVVILSIAIIVVALLLEENILKYVNDKNAYRTSKVLL
DRVITVLDKNDKSKAELIESLKDDYIVRAEAVSYIIDAKPEVEYDVDELQKIAKLMAIDE
IHLFNEQGYIYSGSLPKYFGYSFNSGTQMGYFKPMLENKSLTMCQDVTPNTSEGKEMMYA
ITWNEDGTKMIQVGIEPKRLLKEMKQNAVSSVVAGMPVYKGMEIVVADEDTQVIKGATDS
NKIGKNLDEIGMSLDNLCVDDASATHIRVDGKRCRCMVRQDDKYIVVVTVEDAFYLQGSI
IAIFIVGAYLVLASCCITYMFSKILKERLEKEKLIYTSNTDELTRCFNRRAYENDINLLK
LSDSWIYMSMDLNGLKRANDSYGHAAGDELICAAADCMKNSFNEYGKVYRVGGDEFVVII
TEKTEQFEDIRHSFDIHVANWSGEFVDSMSVSYGWVFSTERNWNSVYEVSKAADKRMYES
KERFYNESGGR
>A0A1C5WIA5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTEEKYTIRKYKRILFYVVICVLLAAFLLGQYIYPSEREPVTEESITYTGTFYRVLADGT
KEEIPVPGKCDVPAGEPMVIRSVLPQDYHENTIAIRSSLENVRIYIGGELRAVYDTENTR
PFGKNSASGYVFCETSGEDAGQEVRIELQSFTDKYSGVVNTVYCGDKSDIWAYMFHCYFM
VTLVACAMLFAGLVVLIISLVLDIIYKTRFDLEYLGWCMLLGAVWMLGESKLRQLFVSNA
SILSNMCFFVVMLCPVPIMFYIDSVQQGRYRKVYHVAECITYVNFVLCTALQVLNIADFI
STMFLSHMVIAGTFLTVFITICRDLIKGTAKHYKLPLIGLVAAMIAVMLEVTAVYRVVSL
SGIFIATGLVVLLVVTLIQTMDRIRELELARQREARESLDYLTGLPMRHKGEALILEKMQ
KQGGCLGFVDMDNLKKINDVYGHKAGDHALRLVGATLTECMKNAVVCRLGGDEFLFYLPE
VSEAEINMRVRKLFDSFRAAKNAAAETSAASLSCGLCMCRQGDNFEEYYIKADKALYYVK
QNGKNNYRFYEELEEQQLTKRSVNNEGILIKDS
>A0A1C6B9H5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIKNKKERVMPFLIGIVCIAAIAVLLWVAGHFQTQNVQLIQDGVEPLSKGWTYTVGEESH
AITRFPFSLNLEEGEEVLLSCLLPDELPAEGVIMYIADHQNIQVYLEGRLIYEYGNRDHT
PFGDVFGSVTNLIPVPKDAQGKQLSIRAVCPGKFRHYNYNFYPVYLGTKSAAVFNLFQQN
FSSLCFCFIIVLLGITFIVGGVYMNTKKYPSNGSSFFYLGVFSLLAAAWILTDSNVMQLW
YGKAPVIYIGSFFAFMLMTIPFLQYIRQIFVGGKRLLNVLSLLFVLNFVLSTIIYILGAA
ELFETNLMTHLLMLFSIGCIGILCYREKKVYHNREIRGLLTGLVILCAAGIFSIVKFYFS
SHDNNSLYFRIGLLGFIVVLGFSTLKKSLLLVNTRAEAAAYRKLAYLDSMTMLGNRTAFD
VQTEKDLQEQEGIETVAVVVCDLNDLKSTNDTYGHRVGDKMIIGFAKCLMEAFEGLGKTY
RIGGDEFAVWFVNQREESIQEGIRILRETVEKQEPDPRFELKYACGYAFETMEEGKEIKF
NRLFSRADANMYREKLEIKGLDQRLFD
>A0A1C6I4T4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIDKDQELFLDYIKQLLYNTDEATLCRDELSDDVTQLADGIEYLGEVIKDEKIVLSKMAQ
GEVDEEFSISHNYLAAPVKSIQSNLKHLSWVAQRVAAGDYKQHVSSLGSFSDSFNEMIDQ
LSHYREKMEHISNTDVLTGTANRRAFNQMIKKLWDKDIPCAIVFIDIDGLKYVNDNYGHS
GGNRYIKEVCQILKMNLKEDEFIFRIGGDELLILSKKEDAHICEERLLEIRLQFREEMKK
KVPYPCDFSFGCVDIDKKENKTISEYLSLADKKMYHFKMQHYIDQRRPKYSNHIDKSGLD
SRIFDAFSQTSINRYAYICNMETNVSRWSVQAVKDFDLPYEYMYDAGKIWEEHIHPDDCK
EYEEDIEAVFSGKKECHDLTYRARLKNGKYIKCRCEGYVLRGRTAKEPNLFAGILTRVDE
AVNYEER
>A0A1C5VXM6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKSLKYKIVLAIVIIVCIMDVNFIFVNYVNYMNVNRNYTDSLAQTVANTCSLVVDGDSV
TGYLDNRRRNTAYYEVWNKLIDYRNTSENVLQISVVNFRDGGGCYVYDTDLTENGAFLGD
IRPYDEVQNAIKDELIACEKIEPLEYNGRSDYYIPLNSSYNIPVAYIIVGISTENVRREQ
LTYLGYITIIVTSITVLFGVFMIWFMQHNVLGPLNAMSKAASSYSIAILRDGKESPISRM
NIRTGDELERLCESMKKMEHDIIASSSQLAIADWNSNHDSMTQLYNKRHYKEQLKELQND
CTIGVIYFDIDNLKRMNDTFGHEKGDAVILKAAEFIRRYLTEQASGFRIGGDEFVMLIRD
CTEEKVQELVSTMRGDEKGNLSDVTAEFYCRLAIGGAFRKTAETLEETIKRADDEMYKNK
HSVRKA
>A0A1C5KI14|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MITENGGKNMGYDRMEQEKSPTEMMYGLTRAFYEEKDAEKILGFYDPKAICWFGMTERGE
AYHIQSLREKLQTIFENMQKTCMEKENYRVVTENNKSCMISGNLALLENGERIENEISAF
WTFFQGVWYLSRFSIQHAGMTPEPEKEAWEEKLDLEKSRNQTLMNLIQGSVLEYDVLKDQ
LDLYIQRSMREPKKHMVYPDLVKSGKALFQAAVHPDDREKLERAFLKNQDYRIIEFRFQE
KEGFYSWKRLTLQKVRDSKGKLLRILGNVVDISLERELLEEARKDSLTGAYNRYGLRTCL
ESYCGELKRRKRGVKGAVLLLDLDNFKNLNDTCGHPAGDQVLKDLVELLKSHFRSDDKIF
RMGGDEFLILMKDIPGKDIVCRKGQAIVEDFSKYAAQYDTHGILLSLSIGAVVFSGKSSG
SREIYQRADEALYKVKRSGKKGICIDEN
>A0A446CJF1|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MKSDAAQLDQRIAALLADPAYAGHPLREALDALWRHTADQMARIERVTQLSDAYQSMAHE
RELGLYDRFDRQLRRLTRIARISDHYQSMMRDLNVALLETSNRDPLTGLLNRRALMEMIK
QEVHRASRGGESFVVAMLDVDHFKAVNDRYGHETGDRALVELAGVLGKNLREYDLCGRWG
GEEFLVLLPNTQSEAAQRVMDRLVGAVRSLTIAAGDGVLRLTVSIGMAYHQLGETFSETL
SRADQALYLAKQDGRDRVALGFPKR
>A0A2S9YC42|diguanylate cyclase|EC 2.7.7.65|Enhygromyxa salina|TrEMBL
MQELDRSAARKWGGCGSSWTWALVGLGLAPGAPLGLWLTFEWCGVDVPSEAVKAALIYSA
VGTVIVLTAFGWGMGRMVDQVRSASLHDGLTGLFNRRFLRESLPQMQAAAARRGEPLCVV
MLDLDLFKEVNDSHGHLVGDQTLCAVSQALRDHSRKSDLVSRYGGEEFAVLCPDTDYATG
LQVAERLRAAIEGLDASKLGHPGPQTISVGVALQSPHQQLSPEELLDHADMALYRAKYAG
RNCCVAWLDGDEPRPVLTPSRQSASVIE
>A0A245ZE83|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MRFDLFTLYLLAVGTLVLSAALTYWELRARSQRRAELRLLTASYLLLATGCAIGGLRGLL
PGVIGAAMGNLVIVSGYLLLLNAVALFSRRRHVRVSIALWAGLAFAWLVGGARLEATLWS
YLGGIPIVVASALTTWEMIRARALRPLRARRLVVAILAVHSLFYAARVVVLPLLVARYGA
PALAFAGMLTMYEGVLYSVGLPMALLSMIREEAHRQLLESSSTDFLTGLGNRRWFFDQGE
RLLRARDGQGSAAPASLLAFDLDHFKAINDQHGHAAGDAVLQIFADTARATLGPDAAVAR
IGGEEFVALLPGFGHGVARDLGRVLAARFAAAVPQDPRTPGIAATVSIGVAEQDAGQGVG
GTNLGELLSAADCALYLAKARGRNRIETAAPTAIPAAVPTHTAPTLVIAG
>A0A8H8ZKY6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDNFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
ISRLADNVILPT
>A0A3P6M8X5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDLGQIYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATRGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVGNDSNLLIVFYVQIMPDDFVMQLHRF
>A0A3R0K118|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIQSTRISMGLFFKCFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A1S8TGQ5|diguanylate cyclase|EC 2.7.7.65|Clostridium puniceum|TrEMBL
MLCVIDENLNFLKVNREFEKVLGYTAEEFEEKNFLSLVNKEDLPKTMNAIRNLNELEPIS
GFVNRINSKVGGYRYLEWYIQINSKYIYASARDVTEKIKQEANFNKVSYKDEDIGLLSID
FFNKRIAEEIERADRYNDPLAMIMLTLDNLKTHKLDSSAKEEMVKETAKIAKSVIRKYDI
LVRIDDEKFILLMPKTNKSGGIVVAEKIRRALNETIHPIVGKFMASFGVSERVKAESLKQ
WQERLNKLLISSQEQGKNFIIATKFE
>A0A0S4IE24|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MVFPAQSRLLPYAALFSLTFALTIGGILARPIESLSLFWPVNAVLAGVLLRYPRQATVAG
FVLMWLAMVGADLLCASALGPALWFNLCNMGVVVTVWQLLSRLPRLHRRMRTPHGVLSVF
GACAAGASVAASLASVMAAPWFEQSLRSTWLAWFSEQFSTAVLVLPVMLTAPAARTLLRG
GSQRIRLAPLMVMLVSLAFSIAFGGPGAIAFPIAALLWCAWTYSPFLVSLLTLTAGSTLI
VAVAQSLMHFSVPQSESGVTALMSARLGIAMLVLGPLVVACVTQANRSLLARLAHQATTD
HLTGTLSRSAFTRRANALLESRQHQQFLPLTLMMLDIDHFKSINDAHGHAVGDQVLRQFA
DALQEQLHSGEVFARMGGEEFVIIVPGLAPDRAQFTAERLRRAVQDLQVEQAGQRLQITV
SIGLAGCDEGMPTPDLTTLLASADKALYLAKAKGRNRVEQAEPQRRAI
>A0A6P1S795|diguanylate cyclase|EC 2.7.7.65|Pectobacterium polaris|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIVTTSQKSFTLLRALADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRGHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAYTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKDNGRNRIEYAPEE
>A0A6I6MRN5|diguanylate cyclase|EC 2.7.7.65|Terricaulis silvestris|TrEMBL
MINDLSLFRGPPGVERAREIIERMGKQQIPTSPANYEIWTTHVAGVKPDLSREIEARLQR
GEAFTDETNEELFERFFANTRLSIQMLETSETIARELDDTVSSLRGAGGQAGSYAKVLQE
AASRFEGGVDSAEFRTIVEHLAVTTHEMVESNLKLAEQIEAQSRQVEELQTALQSVKVEA
LTDGLTGLANRRMFDETLRRRMNDAAADSSDLCVLVFDIDQFKRINEAWGHALGDQVLRY
IASVMRAHAQGDVLAARFGGEEFALIMPRTNVNLAEALAARISRAVKSKRLSLKSTGDVI
GEITVSIGIARFRDADQSGDLAARAEACMLAAKHGGRDRIVTDAQLDRQSAA
>A0A5C6AGR1|diguanylate cyclase|EC 2.7.7.65|Botrimarina colliarenosi|TrEMBL
MPVNASPDVTSPPATVGDAPPAPSTAGVDVGALLRSVDAAAAVSGKSSPEQRAAGAAEQH
QLVAGRLGMASALFTSLRCKHPPTADHSLRVALGCSAWAAALQMPDKLRTQLEAAALLHD
VGKIGVPDSILNKTGRLSDIELEIIDSSREASRHILHSSGAPDEIIDGVVSASAWFDGSH
RSVTLTGDQTPFVSRMIAIVDAFDSMTTDQVYRPARSRDQAIATLYEQAGTQFDPDLVRS
YCELFSHDQRQLEADVAARWLTSATTTSLPWKATPRPAEAASEGSTPPSEPDLFTTRLVE
NMHDAVMFLDSQRIITMWNSGAEKLTGVGATAAIGKEMTPSLLDMAAATGELIDEAACPI
KKSLGEGMQALERVSVMGRNGQSVTVDMHVIPVSATGRPGHFVGATVLMHDVSSEATLEE
RCQALHAEMIKDPMTQVANRAEFDRMLAAFVEAHLDTELRCSLIMADIDRFKSINDTYGH
QAGDEAIMTFAGLMKSMCRTGDLVARYGGEEFAILCADCNNATAAKRADAIRKKLSETPH
TNLGGRTITASFGVTELQPGDTPETLLRRSDRALLQAKDQGRNQVVQLGGGMQTENQPKA
GWGGIGKWLLGSIGGGNGAIVQTRLVTNVPIELTVEKLRGFIADRDAEIVKTSENYIRLI
TEEADGSGSRRGSDQPISFIVDIHLSQVHIERTNNVGLAAGKYVHTYVDVKIQPRRDRDR
SKAKIVDRARKLLSSLQAYLMAREAVAEPTTV
>A0A0H4WGQ8|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MRFAMISSDKTSRAHRIPLRKRVSTLASRHSGPSLPARCPAALCQPALRRKLTELEAENR
RLRRLVVTDDLTGIFNRRYFAKRLREALHAPQRGLGVALCLFDLDDFKAINDSLGHAAGD
RLLHAVAQAVKLQLRRNDDCVCRVGGDEFAAIYSADSPEKALRQAEGLMSAIRQLNWGQT
GAVSATFGLVWLPPGVMVDWQHAYARADDALYRAKHREKGGITLLDAAQAV
>A0A5E7F166|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAIKLTCLSPNGAVMHRGMAVCPAYGYARNVLHLPIINNHSDDMSQSETRATALALYPE
DSREAAALLKQAIPLMVRHNIPPNPVHYALWYTYSKGQDLELNRHLDRVVKDFDCFPPES
ATRLFRDYIIRDELEEARAGQQQAINLVDDMQRDVSRSVEGNLNFQSSLGRCLEMLESPV
NERLPGILSELQQSTQLMQSQQEQFLSQLHTAQSEIKSLRSKLERAQLAATLDGLTELLN
RTAFTRLLEQALSNESQGVALVMLDIDHFKQFNDQYGHPLGDRVLQHVGQVLRSSLPPHA
TAARYGGEEFCVVLQHCADLASAAVFAEQLRVKIQSLRIKARVDGKVLDTITASFGVAFA
QPGENFDSLLTRADDALYQAKRTGRNRVHR
>A0A5E6PFH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSPIETRATALALYPEDSREAAALLKQAIPLMVRHNIAPNPVHYALWYTYSKGQDPELNR
HLDRVIRDFDGFPPESATRLFRDYIIRDELAEARAGQQQAINLVDDMQRDVTRSVEGSLD
FQNSLGRCMEMLETPTHDHLPGILSELKHSTQQMQNQQERFLTQLHSAQDEIKTLRSKLE
RAQMAATLDGLTELLNRTAFTRLLAQALRKPAEGVALVMLDIDHFKLFNDQYGHPLGDRV
LQHVGQVLRSSLPPHATAARYGGEEFCVILEHCADLESAAAFAELLRVKVQALRIKARID
GKVLDTITASFGVAFAQAGEQQDSLLTRADDALYQAKRTGRNRVHR
>A0A5E7U0X9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENQRGKGLSFARRIYLPRAIGLGIGFFSVGAALYPLNMPGWLWALLLFNGFAWPHLAYQ
ISTRSVFPYQAERRNLLYDSLCGGFWAACFQFNPLTTVTILSMMTMNNVAAGGYRLFVFG
ALAQLAGVLIGWAIFGFKFSLTMTQPQVWACLPMLTLYPLALGLVCYRLAIKLSQHKRTL
SALSRTDSLTGLLNHGAWKDLLHLKFQQCRQHNTQATLALIDIDHFKGINDSFGHIVGDE
VLRQLSKNLKRLLDQYELAGRYGGDEFCVILPTLPLNKAEALMEQLREAMQQYRHPQVSE
LRVGLSIGLARYQPLYKDPLDWLDDADKALYTAKHKGRNTISVALSRAATDNVSA
>A0A5E7WMA4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSDTVLKQTCTLIGQRLRASDVFCRIGGEELAILCPFTSQENAEQLANVLCQSLANHEIA
VAGRVTASFGVASWTADLSTEELLRRADQASYSAKQNGRNRVVSA
>A0A379IHE8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENLRGKGLSFARRIYRPRIIGLGIGSICVLAALYPLAMPGWVWALWLFNAFIWPHLAYQ
LSSHAAFPYQAERRNLLYDSLSGGFWAAATQFTPLTAVTILAMMTMHNVAAGGKHLMIQG
MLAQLVGVALAWLVFGPSFNPNVGLIQVYACLPMLILYPVAIGMASYRLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLQLKFHKCQQQQSQATIALIDIDHFKQINDAYGHIVGDR
VLRQLSKELQRNVRENDLAGRYGGDEFCVILPDVPLEQASYVMERLREMFSRYRDPQAPE
LRVSLSIGLAAYQVQFTQAHMWLNAADQALYAAKGTGRNRVTVAESLIARSA
>A0A0B7DDM8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEQKRTFGTPRLLGIVWPFIAVVLFQALLGGVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LNLYADSRDEKIFLKYQTAIGVPQGGHQLRLALDRQPPDLAAAREGILKGGNHPDDVSSV
IWLYLNFRHFSYLETAIDRWTVGDAYLIELDDLAREMHRSISENTASSADILRWKAQIFA
INDAVTPAAKAFSDALGEGSRMILRLLLAINLATALGLIVLALLRTQKLLKQRHAFAEAL
QLEKDRAQVTLQSIGDGVITTDVTGAIDYMNPAAEAMTHWKAEQAAGLPLAALFNLLDDN
AQAEGLTLIEHILSGQLGGGSEHSKLIQRLDGSTLSVTLVGAPIRNAGKVSGTVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQALHTLTRQAGRHALMFLDLDQFKLVN
DTCGHAAGDELLRHICTLLQSGLREGDTLARLGGDEFGILLQNCSPEAAEKIAEVLRHTV
QNLHFVWKGRPFQTTVSIGLVHITQTPTTLETSLRAADMACYMAKEKGRNRVQVYHADDS
ELSLRFGEMAWVQRLHMALEEDRFCLFAQEISPLKPSEGKGGHIEILLRLHDEAGRMILP
DSFIPAAERYGLMSQLDRWVVQNVFKVIAQCIAQEHEGPLAMCAINLSGITIGDDAFLNF
LREQFVNYSIPPEMICFEITETSAISNLGSAIRFINELKGLGCYFSLDDFCAGMSSFAYL
KHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKQTIAEFVETTQIEQALLEIG
VDYAQGYVIERPQLFTCDSLQSRPARPQPLLFKAPGTFR
>A0A0D0TCT9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVHEKPCLPDVPTAEPPRPAAAATLLALMHAQGEVERLSEREQLLSSLLVSVNAVLWAID
WETRRVLYVSPAYERIFGRSAGLLLADHREWRNSVHPEDLDYAEHSLARVLEQGAVEDRE
YRIITADGQIRWLCDKCYINQQVVPGEPLIVVGMAEDITEKKLLELELHRLATTDVLTQS
SNRRHFFECANQAFDNACVQGTALAFLLLDIDDFKDINDTYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCAPEMALQVAERLGKEIQALLFSYEGREFNVTVSQGLAS
LREDDSTLDSLFARADAAMYEAKRLGKNRVIAG
>A0A379JA28|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAAGGKGLPLAKRLYKSRTLGLTLGFVCVSAGMYPLDPPGWVWAWMLINAFAWPHLAYQ
MARRAENSLRAERRHLLVDSFCGGFWVAAMHFNPLPSVTTLSMMTMNNVAIGGLRFMLMG
WVAQALGIGVALLLFAPAYIALTTPAQLYACLPILMLYPLVLGWICYRQAITLARHKREL
LALSRTDSLSGLLNHGAWKDQLEIEFARCRGGQQGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKILRQNLRATDLAGRYGGDEFCVILPDMPLGHATEVMDALRDRFSSLGYAQDPT
LRASLSIGLAPYQASHDDATSWLNDADQALYEAKSGGRNRVRSMQGGWVRSV
>A0A0M6ZZF1|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MTPLPLFSANMLLLSVFAISFLAISFSARPNRHWRSWAAANALSVGALASFASLSALPPI
ATYLLPNILLLAGFGFHLHAARSLKQVSTPYGVVIAPAGVYIVVAAFAYVFEVYALAYVA
SNLLFAALCISIAATYGSAAFRGLVSSLALIIAFGLLALEAGLRIVHGALAEGPFGPGMI
DDGTVNIHLMISLIFIAISGAFSMAISFEQLARNNHEDARRDPLTGTFNRREFLRRLEGQ
LQPATGAHFGLIQFDLDHFKQVNDRFGHVAGDEALVKVCQAIRHHLRRSDCFARLGGEEF
GLLLPNVGQEDAVVIAERIRRLVENQSYEFAPDGFQITISGGMYHGTGKGLTPTDLFKIV
DSGLYTSKNAGRNRITMAAQENETPKFSEELAQLDGLNQPENELQSAV
>A0A737HZK9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z36[z38]:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A1C6CL12|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MMNDTAKRRRIKIGLLVSHLEDDFDDAVAEGAMIGAEQCDADLVIFPGRYIDGVYADKLR
TVYEYQYNTLFDMAAANKFDVLLVLIGTLGTYLDNEHKVQFLKKFAGTPVITITAHIDGY
PCIMLDNRTGMKEAIEHLIKVHGCKKIGMVSGPKTSDDALERLDVYKETLEENGIIYDEK
RVAYGNFSKFCVDEVGKLIDDNPELEAIVFANDQMAIAGYKAMEERGIRPGKDILVTGFD
DDPVAEELNPHLTTVKADPSELGYHAVQEAVNYVVNKAINNDKISSEMVRRNSCGCQGNS
KLKTISFGRISDDPEAFARRMSQFLFNKYSASETTAKMRENYVKIIYALDDYAREENLDN
EIKKDKVLEMVSTLASEEFFRFVNVDELYASVEYIQQKLISRFDNVEKHLKLNQTFIQIY
KILAERNANYCKEKLEDNEFLAWQANSITRDMLVFEAYDDRAYETVVDKLMRLHMESSFL
FSFEPAIIHFGTDKWQPPEYMYLKAYHNGSDAIQLPHEEQAVKYTELLSNKYLPTDRRYT
LVVSPLFSNEEHYGILMCEIKHEYFNYLQSVTVQLCAALKIITLMKQQAVTQKQLKKSLI
EIKENNELLRDLSRQDALTGCYNRRGFFEELRKRLSNDKNEGEKAIMVFADLDCLKTIND
KFGHEEGDFAILSAAKILKHSFGNSEIVGRIGGDEFVVCAFLDNAIDIPSMRNHIEAVTR
EYNIKYAADKPYIIHTSVGVYPFVCSATLEIGELLSHADILLYEEKKHKRSILKSDYE
>A0A6V9XUM9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Decatur|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A829J464|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KOEGE 73|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1V5E7A1|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaU1.Bin208|TrEMBL
MHQQLSMERISRYARLALPLMSKHDIPLIPENYSVWFTYVSGADKDLTNRIDMIIKNGAY
FTNTTNEELYRQFFTEKNDHELERIHKDLHLALVTIIKHLMELSGQSQDYESFVSDSVSM
LSEKSSLEDIRNITREIIKKTKIMTTFSKTLQNELNHTMKTLEGLKKDFEQIKMEIIEDF
LTGMANRKAFDETLAIKMEEAKVESKDLSLLLIDIDHFKKFNDKHGHLIGDEVLKFVAKK
TKEMVRGIDFVARFGGEEFAVLLPHTSLKGGVVVAENIRKFFAKVQLKASSTSKPLGSLT
VSVGVTSYRPGEPRETFLDRCDQALYSAKKAGRNKVACA
>A0A0F3QB46|diguanylate cyclase|EC 2.7.7.65|Rickettsia bellii str. RML An4|TrEMBL
MSANILIVDDIETNIKLLEAKLLNEYYTVFKASSGKEALNILKKEKVDIVLLDVMMPEMD
GFEVCKKIKSDPETTHIPVVMVTALSDVDDRVKGLEAGADEFLTKPINDNALFIRIKSLS
RMKSLIDELKIRNSTNALLGGINVEIHDNFADKKILLINDDVVQAKNIKQMLLKITSNVK
VISNPEETDTINEYKPDLIVISSTLENEDPLRVGAILRGKPEISGVILILQIYEDENGNE
NQMQLVMKGFELGINDYFVYPIDESELAARIKTQLRRKQYQDNLRNDLEQSVNLAAKDGL
TGLFNRRYFNVHIKQIVEKANKEGMKLYLLMCDIDNFKHVNDTYGHQAGDKVLITTSRIL
KNTFRVTDLIARFGGEEFTILLNDINIDQAIYTAERVRVKIESMNFQIDEQEEPLKKTVS
IGVTEYKKCESIEEFIERSDKAMYEAKTTGKNKVVKL
>A0A8D9K9K1|diguanylate cyclase|EC 2.7.7.65|Staphylococcus warneri|TrEMBL
MFEAIIYNISVMVAGIYLFHRLQYSENKRMVFSKGYVTVLMTLVALLLAAYPIPFRLEYL
VHLTFVPLLFLGRYTNMVYTLASGVVVSLVDILIFNNSIIYGITLVVIAGVVSAVGPFLK
QNDIISLLILNTISIIILFILALVSPIYDLIEIAILIPVSFIITIASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNQLSKYTETHNESLGLLLIDIDGFKDVNDTYTHQ
AGDAVLKQMSQLLKNYVPKQFLIFRNGGEEFSVVINDYTLDQSVKLAENIRQGVEKSSFH
LPNKEVIKLSVSIGVGYLTQDDRKSQRRVFKDADDMVHVAKSEGRNKVMFNPIIKL
>A0A4R8SYL8|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MPLNRIVTYIRSTAWMSFLVQWWTEPVPTGWLRAFLRARKLDRTVRNLIGGYALIFAAIC
VAVQFSDTGPRSTVGRTIVGVCAVGALGWAVRWAVGPWPSLREAVAFVAFADVGIAIACW
QDSDPLAGLVGTVLFTPVGAYVSFFLGNRLLLAHVAWCGPMIIALSSRLFAEGTVGAAMT
AVVKVTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYGEWQRLHSGLTR
GDMLEGDRVIAAAIVDIDRFKSINDRYGHGTGDRVLVDVAGALTAESGRGNLVGRSGGEE
FLVVTVCPAEAVAEFATRLREAVTTSTPAGITVTASVGVAAQAVASVASATSEKAFDVLT
ACADRAMYEAKGNGGNQSRILHPGHALVDD
>A0A6C8LW38|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lubbock|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>D6CSJ0|diguanylate cyclase|EC 2.7.7.65|Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)|TrEMBL
MLSLVQPQIGYLAILLDRLLTHGELRVEFQPVFDLRGQSIHAFEALARGPQSSPLERPDA
LFQTARENGRLYELDALCVRTSLETFARLNLPGQLFVNVTQTLLDSGWLGSSAALDLLQR
LGLPPSRIVFELLESDDLLKDGVGMEQAEHLHRLGFTLALDDMGRGFGRFEAWQRLHPRY
LKIDRAFCAGLADDAIKAAFVRSMLLMAEASRSWVVAEGVESARDLRVLREIGVQLAQGF
VLERPSAAPSREMRPAQRGLIEAAQPELYPLASRGSVEQSALGLARPIAPVQPQVRLEEV
LRRFDAQPDLMSIPVVDANGRALGILNRYVLADRLWRPHVRDLLGNKPCAQVMSADVLKL
DVSSSLHQASQLIADASFRHATEGVLVTEQGDYRGLLLVGDLLRLVNEFQIQTARYANPL
TLLPGNVPINEQIDRLLASGQSFVAAYGDIDHFKPFNDVFGYRLGDEVIVLLADLLRARF
GRPGDFVGHIGGDDFIVVSAEPDAVERLQTIPQEFAAEMPRFFNADQRERGGYEAVNRRG
EAQWFGFPTVSFGVLTLASGQVESHREVSALLVELKKVAKAQAYDRVFIDRRQYGPQMPP
ALR
>A0A7G2JK50|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MGKAMNARINTKHGLPATIQLITLFLLAFLLSLLGIFTRPIGSLSLFWPVNAILLGLLLR
KPAYATPAGWLITYLGMIAADLANGESLSLAMWLNACNMSLIGTGYAVMLMLPKSQRRMG
KPQAILYMFTASLSGAAVASTLSILRNESLYNNTAVIAWLAWFSEQFSTNLLLLPVLLAA
PRLKQLLRMQINWQLRAGMPLLALLFSLVFSVYIGGPGAIAFPIPALLWCAVRYQLFTVT
LLTLLTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAVNRK
LLRRLEHSANHDFLTGVLARNALTRKAGELLDHKHKSKEAVSLLLIDIDHFKQINDTYGH
LVGDQVLASFAHVVRRELRHDQLFGRLGGEEFAIMLPRALAAQGLALGEHLRQLVEKADV
YPRGKTPLNITISVGVASLAMNEVKSLEQLMNMADIALYRAKSQGRNRVESFNVVSGNSI
GHIMFK
>A0A7G2JM94|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MHTTELSGATKLQHAVIVFLLVFATCIFGIESRPTGLLATFWPTNAVLLAVLVRYPKLAS
PVGWLMAILGYLAADLITGSTLGKAILLNGANIAGVAVGFYLFMRLSPQIRALERTSSSI
YLFAICLASATATGLLGAGASVLLFGRQYLPSLALWLSSEFTNYITLMPFILAFPVDWKG
YLRGITQAVTLRSQWYNTCTKVAVLILLTLACICSILIGGPGAVIFPMPILLWLAMTFSL
FSTMIAVLAYVLWCHLAIDLGLITINLDMTLLQNTVSMRLGVALLALGPIAVASMNFARN
ALLRRLEHVANHDALTHVLTRSAFMQRGTRLVSQKGERVCIMMLDIDYFKSINDRFGHAG
GDVALLSFTRAIMGDLRDQDLFGRMGGEEFAIVAPIEQPQDAMSLAERLRRRIEIEAITM
PAGNHLQITVSIGMVTCIGGSEQNLDNLLKIADLAVYKAKNSGRNRVATPELLPRNSPDL
>A0A8J7VPF4|diguanylate cyclase|EC 2.7.7.65|Cypionkella sp|TrEMBL
MVGKILIVDDVATNRIVLKVKLTEAGYHALLAVDGTTALAMAAKERPDLILLDVSLPDLD
GVTVLQRLRADPLTRTIPVIALVGTNAHHSLRTNVFRAGADAFLAKPVDDQTLLARIRSL
IRNADQMDGLARDKGKLALMGFAEATPMLERPGLLALITATPERGLHLRHALAQHSHDRI
VLIPPDDCLRNGLIDGTAPDIFLIDSDLASPGAGLRLMSELRSRAPTRNARFCILFSEPA
QINAAMAFDLGANELIEVTTGAEETALRLARLLARKREADRLRASVRQGLRLAVIDPLTG
LHNRRYGLAQLTAIHASSLSSRQPYAVLIVDLDRFKTVNDRFGHAGGDTVLIEVASRLRN
GLRDQDMLARIGGEEFLIALPDITLAEARGIAERLGEIIRNSAIVLEQDIALFITVSIGL
AFCSASAGKIASADQPDNDAVSQIIARADHALLASKSAGRNKITISRSAA
>A0A8F8BIG2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. steigerwaltii|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWASINITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSTMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGVEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLIHGEINTYTLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPSHIKPTWQLWHAAMV
PEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDTDMVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A729Q7M5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 18:z36,z38:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKTDAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A380G8K1|diguanylate cyclase|EC 2.7.7.65|Staphylococcus intermedius NCTC 11048|TrEMBL
MIEAIIYNISVTIAGIYLFHRLQYAESHDFRFSKSYITVLMTIVGLLLAFQPIPIENYMI
QLSFVPLLFLGRYTNSIYTVFAAVIIALVGYFVLSTTLTYAVSLLVIAAIVSTIGPFLKQ
NHVVAIQILNILSIMILAIIAMIMPSFDIVEVFYLIPISIIATLVTAVFYVDLLRFFSLI
ERYENEDTVDYLTGLGNVKEFDRHLNEMARVAEDEQQSLALLLIDIDGFKDVNDAYTHHA
GDAVLKQMSHLLQNYVPKTTHIFRNGGEEFSIVLRDCSLDECVKLAESIRKAVEKSNFHL
PDKIVIKLSVSIGVGYMTSESHKSQRKLFKDADDMLHVAKNEGRNQVMFSPIINPK
>A0A8H9PLQ2|diguanylate cyclase|EC 2.7.7.65|Kluyvera intermedia|TrEMBL
MNCFPVKDESFAKRHSHLKRPACPGVFLLSVICRWQSHNAFSVAFIQGVFVGQEKVVKSP
PRLAFVKTWFVPSRVVNLCFVIVLVCSTVLTWREVIVMKGAYVVSQRNALENVANVLDRQ
MQVGIDRLLFFRNGMQSALQTPLAFDVLRNIQAEFEQKRMLPYWQIVLDNRRTLPLYGVS
DYFVEQSASLSRDNPLLHNELTAAMELGYLFRFASSATMFPRRALYVSRAGFFISTLPVG
NNNEIVQQYYQYLTSPWFSGQSERENKLRGVRWFSDEAHELSLADSLVTASVPLDYENNW
YGVLSMSFPVSSMKALLTEARQNQDRGEYQLYDAQFALLTTTAERGTANQQFSSEERAQL
KREMAKDTAGGLRLGTRFVSWEKLKHFEGSVLRIQTLREGLRGDFGSISLALALLWLLFT
TLLLLSWGVIRQMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERARVLTKECAAQNLPL
SVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEEFCVLLPGATL
LDATVVAEKIRQRISDKEIFVQKSKTIRVTASLGVSGAQEGGNYDFEYLQSVADSRLYQA
KNNGRNQVCAEDGVSPLPNT
>A0A653ZQP4|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. T1|TrEMBL
MCVKPPPPITIEPPVLHRIAARQAERARRPDGGIDTDRLLALVSATYAETDVDRRRSDRA
NRLMAQELEVALAESALQNLRFKAALDNMNQGLALFDASRRLVLTNQRFLDIYGLDHAVP
GLTLDQLLTNSPCLSVSTADEHRRLVEEYDGAASAYGARIEQRWPDGRTITIERTRLVDG
GFLDTVADVTEARNASARLAHLARHDALTDLPNRTMLRERLDEMMRNARSGDRCAMLCLD
LDRFKLVNDTLGHPVGDALLVAVASRLVTLVRHHDVVTRLGGDEFSVLVQHVTSDHAIEQ
LCRRIIEALTQPFEIGGHHIQIGASIGVTMVEVDALDPNVMLRNADLALYSAKAGGRGNY
CFYTPDMHVFATRRRELEIELRRALKSEEFEVHYQPQVAIGTHAVVGFEALARWYHPERG
IIPPNEFISVCEEIGLIGAVGEFVLTRACRDAACWPDSVKIAVNLSALQFKSGTLPAVVA
HALRVSGLDPRRLELEITESAMLDDTASVLRQLRDIKQLGVLISLDDFGTGYSSLSHIRN
FPFDRVKIDQSFVRDLGTNSDSLAIVRAVTGLCGSLGILSTAEGVETLDQLNILVAEKCD
SAQGYYFSRPVPFVETLPFVSRMHALHSQAA
>A0A7V7JAL4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKEITSTPRPTFKSTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDALAANETLTTLGKQGQFAVAEVLNAHKKRFAYWSWNPEENNDTLGALVS
RWLFPDPVAQPIMHNGNAIGEIRLTARDNLISHFIWLSFAVLTGCILFATAVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQTK
NAQLLRTAMHDPLTGLANRAAFRSSIAALMHDASAKTNTALLFLDGDNFKFINDTWGHAA
GDCVLIEVARRMVEFGDKRHQSYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDL
HNGQTATMSLSIGFALAWESASVEALLEQADRNMYQDKNQRTKAIT
>A0A330GB99|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKDFSSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINAHQKRFAYWSWNPEDNNDTLGALVS
RWLFPVPIAQPIMHNGTKIGEIRLTARDSLIGHFIWMSFAVLTGCILFAAVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKGGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTKSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSEPEVQHICAALSQQFIRPFDL
HNGQQASMSLSIGFALAWENASVEALLEKADRNMYQVKNQRTKTIS
>A0A1W6K825|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MAIKEIGASTFHWLVDMLESVEVGLVVLDLDFRVQAWNGFMEHHSGITASKIREQVLFDV
FPDIPKAWLTRKVDSVAMLNTRAFTSWEQRPYLFRFRNTRPITGTEDFMYQNLTISPLSG
PDGQVEKICLMVYDVTDIATSKRALETANEQLAKLSMTDRLTGLLNRGTWENLIDAEYER
YRRYGHNTCLIMFDIDHFKAVNDTYGHLAGDEVIKYTAKVMKDNLRQSDSPGRYGGEEFG
IILPETDAEGARVIRERIREAIQNSTVQTTAAPIQYTVSIGIAPLTDRPENHMQWLQQAD
EALYAAKEGGRNRVVVFGEQS
>A0A8H8X6M7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MLAICRFVKNRFVAFALGCIVIIAVLQAFFIKLVEWVPSFSPLFFPTLTIFLLVFHLFIA
CFMAMKYWCDRRRLYLVPIALAFAGSALLMVGTLSSFPAWLDLYQFNVANYNDAMIFYMF
RHFLMAVLIIISALLYTLRTSALSRSTHIGIVVGASLFTGSMLGLALFYSSHSTLLTLDL
VDNETRQFMVLWSQAINIILIVLWVVTLITLMAITRVRNLFWVGGNFLCVCYIVTLLMLL
LGGHAEDISWYRARLFETVATLIIIFILLSDVFNLYRDSHVKYQESYQNSIRDPLTRLYN
RSYFYDSLNHALSTATLAHPVSVIVSDLDRFKRINDCYGHLQGDKVLQFVSNLLTDSVRP
QDIAARIGGEEFVLMLTNTPSDLAQQVAERIRLKLSGFDNVSSGGYLPEPITISMGVFTA
TSPETSAETCVESADKAMYEAKETGRNRVVVFRT
>A0A1W6KD31|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MAQMAEKFLLSRLSRTGFLILIAIAAFSVIQRETLTAITAIVAAALVFSGNTFHPGRSRQ
PWPAIHRLLFVALLSLLATSLWTGPWSLTHWLYVAPLVGFALLPVTWAAAITALCAVLAM
SATHWSAGLPERHQMLSALLLTVMLSGLLVFLREYKSRQLAPLRRTDELTQAASREYLTA
DLHKEIQRSEREGTDMSVIMIGLDTHLSDSDPDADIRSILPRIGRYLHSQLRDFDTYYRV
ADLQFLVILPGIPTAEAASQAETIRKGLRTLLASHQLHLTVSAGIAGLNIGDDADSLQQS
AANALRRAQQQGGDRAQSYSTWTHTSPPPRTEGPAL
>A0A377LYT1|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MRRPLSVCGHTLSTTLSAGVSRYPQDGETLHELKLKADAAMQYVKKQGQNDWAVYRTEMS
TAIPANPGFLQELTQALERDQFELWYQPTWHAEERTIHGFEALLRWRHPEQGVLLPNLFL
PSLEQTGLIIPVGNWAIEAACRQLHFWTEQGFAHWTLSFNLSPVQFEQPDIFQTVSSLLQ
KYNLSPSRLILEVTESTALKNLDRSIELLSAFNQAGITVSIDDFGTGYSNLLMLSVLPAK
ELKIDKSFVTSMLENEKSRKLVETIINIARTMEMYVVAEGIETEEQRAVLTELGCDYLQG
FLFSRPLPAEQIPWLLLQINSQKQIIPIGKIHSEIRFCFTKKSCYTGLTGVWFRGVHASR
FRRDRQAYCADVQEFLMSQNYFDALNVIKTPVWLISPVSGHIIFANTAAVQVMGDKTVDD
LRKGAFSANAQDVLSMYIPELKTDQEIVEIWTVWRDGHETALSCRLSLTHHAPYGDIIVF
EGISHPAPTGLKASRSATYQRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFY
GYSHEEMCSKHTWEINTLGRDVIPVMSEIAALPGGHKPLNFVHRLADGSTRHVQTYAGPI
EIYGDKLMLCIIHDITEQKRLELELEHAALQDAMTGLLNRRQFYIIAEQMNLTHLPLQQQ
FSLLLVDTDHFKNINDVFGHLKGDEVLIALSRTLEACSRKEDFVFRWGGEEFVILLPRTS
LDTALQIAETIRAAVARISIPACRDLRSALAWRGTTRMRVSTISLNG
>A0A156T510|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQMQTSSAWESFYVMSDIILARVSETLATEQSLESLVRQLLEMLEIVTDMESTYLTKVDI
EARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTVFSNDVPERWPECEAAKALGI
TTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQSIQKESLVTQLREA
NAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNTVIAFIDLDDFKLINDRFGHE
AGDQFLIEVGKRLTEEKRQDDIIGRLGGDEFLVASLSTCHSEGDTAQITLLKTRLSACIA
GEYWLGSVNLIYPGASLGVIEVDPQITDPDSALRDADIAMYQDKKGKSKTRFLTMD
>A0A377M1S3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MFCLYDVFRLYRDSHLKYQQSYQNSIRDPLTRLYNRSYFYDSLNQALGACKASRPVSVIV
SDLDRFKRINDCYGHLQGDKVLQFVAHLLMDSVRPQDIAARIGGEEFVLMLTNTSSEAAY
QVAERIRLKLSSFDKTSSGGQLPEPITISMGVFTATSVETTAEECVEKADKAMYEAKETG
RNRVIVSR
>A0A8F4J5Z1|diguanylate cyclase|EC 2.7.7.65|Aquihabitans sp. G128|TrEMBL
MDPWPGGEAGGRGQRARGFALLVERSADPIVIVDELGAVSYANPSVERVLGYRVDEIVPN
ALDLLHPDEVEEAVARIAAVAQGEPANELVMRRVRHADGRWIWCETVNTNLLAEPTVGGV
VIVLRDVTERLEAEARADVEHRLTQTILDTTTALVVHVDMEGRLLSMNRAAERLTGFATA
EVAGEHVSRFVPIEERILAPGPMAVADVPTVHENHWTHRSGRRHLMAWNNAVLFDADGQP
TGVVATGIDVTAERRAERAARRADRREHDRLAYEATHDALTQVLNRAGLLDELDAQLREA
PPGQPTAVLFLDLDGFKAINDEHGHHVGDEVLKVVSERLVDAVRTTDVVGRLGGDEFVVL
CPGLDAQRAIATAQRIGEAIDAPMLVGELPLACGVSTGVVSAVGGDAATLLHQADLAMYE
VKRAHHEARRPATLDNGPVDPNESVRLSVLRRLGLLDSDADPFVDTIVQLAAQVCGTPMA
AVSLIDADRQWFKASVGLDVLETPRSEAFCAHAILDATETFVVPDATEDDRFRENPLVTA
EEGIRYYAGAPITVGGEAAIGSLCVLDRTPRTLTVEQVGTLERLRDSLVTYLELTAPEGT
FAGVGTEARTGVLLGAVRGA
>A0A377GKV4|diguanylate cyclase|EC 2.7.7.65|Fluoribacter gormanii|TrEMBL
MDFPGVTSTEIENKLITESYKKFYVLVIADFFATIIFASIIWGQVNNKLLLASWVLLMFV
FNQLLRGLFLLRYYRQKKEDGLFRPAFWKKYFIINNFLSGILWALGGLLFLYIDDPLHRM
GIFVYLIGLLGAPAAKLLTIHNAYIAFMAPIWLLLIFLSVSITPSLSLILFMAILLYASI
MVYSTTSVNRFLMKSIYLEIYSSNLLSDLRRSEESFRNTIENAPIGMAIVSPEGKCIHAN
RTLQEILGFSGEELFCKNMLEITYADDVSMTQDAMNKLLQGELRISHMEKRYIRKDGSII
WVMVSATLIRDEHGEPINFIVQMKDVSDRIQNEEKMRELNEKTMETLNELKLLEHDESLL
NRLNRSLQICITAEEAYPRISLIAQDLFPDLSGGLSVYNKGVNQMETVVQWGKEQLLPKT
FLPMDCFSIREATTNVVDDPNKSVPCSHYKTAPQGGYMALPLMVQNELIGVIHLLAPKSK
KLTQHQQDMANSFGNIVKLAIANINLRVSLSELSLHDPLTNLYNRRYLNDILSRELIRIA
RDKNTLCVAMLDIDNFKKFNDTYSHLAGDEVLKSIGKLLKDNFRESDISFRFGGEEFVVV
LLNATLNNAVSKMDALREKIKTISIYFKGNPLDNITISIGVAEAPKHGATIDEIIKAADH
ALYAAKQAGKDKVKAYSQNS
>W6R733|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MDQILSLLSETIPKAQTLEQLARPLLSLLNQFTGMESTYLTTIDTEQGVQRVEFARNAGA
MIIPEGLVVPWADTLCKRALEENRLYSDNVAECWGDSDAAKALGIKTYLSAPIRSQDGRV
LGTVCAASSAQVARPANVEPLLALLSGLLGYALERELLVAQLQAANSELGRLALTDPLTG
LANRRGIMRDLVQLFALAQRDSKYVLVAVIDLDGFKLINDCYGHQAGDQFLLGIATELKR
SLRASDMVGRIGGDEFIVIALGNALQRPAPAQELRDAAALMQARLSKATVG
>A0A8H9YAG4|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MPTAPSAFNTRRAGLNFARRLYLPRIVGLGIGFWCVLTALYPEHQPVGVWILLAVNGFIW
PHIAYQWSIRSEAPYTTEIRNLLIDALLGGMWVAIMGFNALPAVVILSMMGMNNIASGGP
SLYFKGLMAQIIGAVVTSAILGFPFTPQSTPLQVYLCLPMIFIYPVFLGYVTYQTAKRLA
EKQQELLRISTRDGLTGVFNRRHWEHLLHNEFDSCRRYNHPATLILMDIDHFKAINDTFG
HGLGDEALIVLAEELVLGLRAMDIVGRYGGDEFGAVLPNTSAEQASQALHRIQERLNEVV
FREAPGLKLNISAGVADYQPEMLDYQEWLKAADIALYRAKNNGRNRQELAVHQC
>A0A1Y0HJX2|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MSSLDHSLNETMDSIVSTCNLIPEVFRDGIILCDSFKESISISDKVCEFTGYSQEDFAAQ
SPFSLITHCEPIFQKDTVQYATSIQSKLGHSIPIIIYPKIIYRNHHTLFLFIIQKQAEFR
VPLKNYFLAQFPNRFLFLHEMLRQTIRYSHQTNAYGALLLLDIDNFKAVNHVKGYSFGDQ
ILRDIAKKISSVVNTLSVEHLNGDEFAIVYHTHACVYDKAKEEVNTLSRKILDTIKKPIV
VEDQSFLLSASIGVVPFIGEEYLPDTIIQYADGALHEAKKNWS
>A0A1Y0N5C3|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MHDPANLDEKLRIEDLRSFNILDTPAEQAYDDVVSLASFICDTPIALISLVDEDRQWFKA
RLGLSAMETPRGQAFCAHAIVDPDRVMEVPDALQDARFVDNPLVTGDPGIRFYAGAPLLT
PSGAALGTVCVIDKVPRKLTERQSEALRALSRQVVQLLALRRANAELELVAKAQTLRQQQ
LENHQRRIEELNQDLQEQTLTDPLTALKNRRAFETLLANEFARSQRSKSPLCLLMVDADH
FKAYNDAFGHVAGDQALMFVSLAIKSQARAYDHVARYGGEEFCVILPDTKLNEALVVAER
IRESIKSIIGLRRPMTGSIGVAYSEGVPSPKRLVELADRAMYLAKQGGRDRVEIFLPPV
>A0A1Y0NBV3|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MSISLLSKLEKITATRDFVAIEHSLLRAIGSTVHVEDLSLWTLDANHEVTKALHYYRQIE
VLAGSMGRDTEQVDTVYANIEVPADVRSLAQTVVLSLKPAARKTETGGLQMFPLIGSHGL
SGLISMRLSQPMGEHDQELINGILRVYSNYHALLDESQRDRLTGLYNRHAMDLNIDRMWS
VLGRESTQSDARRNSVVQMYALAVIDIDHFKKVNDQYGHILGDEILLLVSRLISSCFRKS
DPVYRYGGEEFLVVAGAESPQAMHTLFERVRSKVEGHYFPQVESVTVSVGYAIIDPALSP
SENIGRADRALYCAKEMGRNQVQSFSDLLQRGLIKDMRYGSTELF
>A0A8F5A1I0|diguanylate cyclase|EC 2.7.7.65|Modestobacter sp. L9-4|TrEMBL
MTSIATPTSSLDDVLRTGAVHSVYQPIVELGTGRIVAYEALARGPQGPLHTPDALFAAAR
TAGRLAELDALCRSAALRGAVAARLGPPLTVFVNVEPEVLESAPLEDLLAIATTAPAGLR
VVVEITERALATRPADLLRAVERVREVGWGIALDDVGAESMSLAFMPLLRPDVVKLDLKL
VQQRPGPAVAEIMNAVNGYAERTGALVLAEGIEDEAHLAMAMALGASLGQGWHFGRPGPT
AVTDREVAALKLPKAIPLDADVHGSPFGCLPAGTELRVAPKALLIELSKHLERQAMRLGE
TCVVASTFQEARHFTPATTLRYRDLVARTGFVCALGADLPVEPVPGLRGAHLHPDDPVRG
EWDVVVLSPHFSAALLARDLGDSGPDAQRRYEYALTYERTTVELAGISLVARVAAQPAPP
EPETTAPTPEVIAALAHSTLVGPSPDEPLLLRALAATTSGVAITDMTAPDQPLIYVNAAF
ESLAGQSAAQVLGRNCRFLQGPDTDPAVITRMRSAINAGQEFRATLLNHRGPQREPWWNE
IHLAPVHDARGVVVQYIGVQNDVTTRVTAERELLTERDRTRQHLARIEELAYTDPLTGLP
NRRRLEERMETALWQARLDGGAVALLFLDLDGFKAVNDAFGHAAGDELLQTVADRLRARL
RRGDLLARLGGDEFLVGLLGLDAATARVEAERVADDLRAALTHPVELAGSEVTVRVSIGV
AVHPEDGDEFGPLLHRADARMYAGKHPADR
>A0A0M7JV70|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MSPRSSHAGMRKRKIGLLAVLVALAVLSVAVGFSNAMYSSYQVQKAQIIKNALAANHARA
EKLAEVIDVYVAALHRQARSAADRLPGSLGKPQALQDELQRLAGQIDSLHAVMLADAEGR
IVARSPMGQLADAKVLRLADLGISAQGPESWVTTIPGAQAAVLTVAEPVEDAAGAPLAYL
AIAITLDAGSGMDRIIGDRDEIAGMSVFLVGSNGDVLYRRHAPAGTFDLASLEPARHGGA
ALYPKADGGAVLIGYAPLAKGNWAVVAQRSLDQVLSPLRELLGDALRSAIPAIVLTLLLV
CGLAYAIASPLSRLTRAMSAGKSPGVDLGRLNAWYAEADTLRDAVELTLNQHQDEVGRLN
TQALTDPMTGLLNRRAMTDVLDAYAADGASVAVIAMDLDHFKRINDSFGHMTGDKVLIAL
AEVIRAGLRDQDRAFRVGGEEFIALLPTGSAEKACEIAERLRTAVARRLMPDSVGRVTVS
IGVALWPQDGESAADVIRRADEALYESKQLGRNRVTLWRDRAATEQSPPNKRN
>A0A8B3JL16|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. WCHEn090032|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSVSLIYPTINVIEAVIGALFLRKWLPWYNPLQN
LNDWIRVAVGSALVPPLVGGVLVSLLAPGAEPVRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAITLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EARFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLDTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEQGPPMENIHSGDMSRSDIDQDVVLNCRTGGSFDIHYSITPLSTLDGQSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIQTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNGGRGRV
TVYEPQQERDHSTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCNPNKNLEQGLQKLREAGCRVIFSQVGRDMNVFT
HLSANMADYLLLDAEVVSNVYGNLMDEMMVTIIQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A851G337|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SECR19-1250|TrEMBL
MDKEITSTPRPTFKSTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDALAANETLATLGKQGQFAVAEVINAHKKRFAYWSWNPEENNDTLGALVS
RWLFPDPVAQPIMHNGNAIGEIRLTARDNLISHFIWLSFAVLTGCILFATAVALTITQSL
HHGMVTALQNITDVVLDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRSSIAALMHDASAKTNTALLFLDGDNFKFINDTWGHAA
GDCVLIEVARRMVEFGDKRHQSYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDL
HNGQTATMSLSIGFALAWESASVEALLEQADRNMYQDKNQRTKAIT
>A0A735IQY1|diguanylate cyclase|EC 2.7.7.65|Salmonella typhisuis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHEQLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>Q0T6C9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>Q0T3H7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVS
DALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTL
FTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYW
YGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALL
AQAMEHDTRGGIRMDSRYVSWERLDHFDGVLARVHTLSEGVRGDFGSISIALTLLWALFT
TMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPF
SVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGANL
TQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLA
KQAGRNRVFASDNA
>A0A8I1ZNQ0|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium|TrEMBL
MWHIIPHDDHNQSLRIKRFLIACASYLMWILLIWYCSIQGMIRLGPKEILLVFAMVLVMN
LVLYAIFRTGLNRRLKDPSLTMVQMSLATAWIMIVAYNLNEARGIMLQLYLVVFIFGAFR
LNLRQFIMLSILAALSYGLVILSLLENHPETVNFKVELLYLVILTAVLFWFSFVGSYINT
LREKLSRANSELNHAVEIIRQKAIRDDLTDVYTRGYLFQILAREKSLADREGLIFSVCIF
DLDDFKKVNDSFGHHVGDMVLKTLSGIIRDNIRQQDYIARYGGEEFVLVLAYPDMHDALA
CVERIRTLISEASFPGLPGDYPVTVSMGLTRYQPEETIDSLLIRADDALYRAKRSGKNAT
ACEPSSLLQPAA
>A0A5P9CPF5|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MRERLGSRWAAILVALLLCVIGVGLVEFIDRSQKTFMHNSMLVRAKEELSIIRSELEIAI
FNDIFVANGLSALIAANPNFEFSGWGLFASSVMRKAHHVELITLAPDDVVKYVYPYEGNE
ALLALDYRTLPERWMTVNKARDIHEILIAGPLNSIQGGRVLIAQVPIFSDPIYHRDYWGV
CSLVISLESLFEDVGVKSYTEKYYLAMRGADSSGEEGDIFYGTQSTFDNAFAIESVKFPY
GTWIIAAATKSDLLEYSDWYRVHAVRLLGYPLIVLLLLAYGTIYYLYHAANKRALHDSLT
SLPNRRYFMYTLERHFALVAGSGKSESFAILNVDLDKFKWINDTFGHAAGDKVLVEVARR
IKSALRLSDLVARVGGDEFLILLTRIKRKEDVDAINNQLQKSICRNPVIYEKNDISVYVS
VGLAIYDERYKEVDEMLKAADDSMYDEKRRED
>A0A741S2N6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sandiego|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8I1ZQU5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium|TrEMBL
MDLDIAGLEAVLSPYIVLLGGTGVHYVSAALSGRLGVDEGEVRRGLDRIPAFVSPGAEIP
SSVALATKGGGEDVFACTAITLGDCRVIALISEKNPARPFVEYADRDTFVRMFTRAPVGG
LVVDRGVVVYVNEFLCALLEKERGQVLGTSVISLVSKEGRQDFIRACQIWHDQGNGEVET
FDLMLTSCRGSRLLFTARGGCIERASRRLIWITLDDVTENHRIRRALKEEQLKFAELFGE
LPAGIIYISPRGRIMECNDYVAALVGRPREQIRGTPFTDHVSPDQAGVLRDDFRELFTDG
REIAKRESTITTMDGRPVTIEYNARVIYRKGHPSKALMMFSDVTDKKVLELELLEKNAEM
ERTLWDMAEVKDALEARAGELNKATEDLKQLNEKLNLLSITDGLTEVYNHRHFQDRLTEE
VERLNRLKGGGVLSLLLMDIDDFKLFNDTYGHQCGDMVLKHIASLLKSSIRSIDILARYG
GEEFAVILPNAGTEQAVIVGERIRQTIRSTPFTYGEAVGAKVTVSIGVGTIVSGNTDKAD
LVRKADSAMYAAKARWKDRVEVWEED
>A0A8J7VR20|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MLLAAAFACAQARDAAPEPAVVHSLERFGLDDGLSQLSVTALALDDQGFLWVGTQEGLNR
FDGHGFEVYRRDPEDADAGLASSSIEALAFDRRRRLWLGTDESGLEVVDLGSWRRWRLGP
GSGLSHARVRHVLLDADDGAWLGTEAGVDRVGPRLDRVRRLGATPPVVGLAPDPAGAGAL
VLDRDCGLWRASSGTLVPLPVELDLEPAPACVAMAADGGGVWLATRSQGLVRLDAAGAVV
ARLAPATLREREVPVTALGALRHGGVLVGHADGAVLEVRLRGGAPEVRPLWLDPVPGSAI
TALHQDAGDLLWIGTYTDGLQRVRPLSGVIRNDRIADAAGWPSRSARAIGEDGGGLLLGT
DAGLLRRRAGAADWQPVAAFAGRSVRALLPADAGWWVGTHDGLYRWDPPRAPVRLEGLPD
ARVEDLLETADGLWIATRGGLALRTPDGAVSRDFGALDGQLLTCLRHDADGTLWIGSNEQ
GLWRLRPGADPERVAAADGRLPDSVWALHADAGAVWIGSFSEGLVRLDRASGATRRFTER
DGLSNNVVYRIVVDGDARLWLSTNAGLTVLNPGSGVIQTLGRRDGLRNHEYNSGSGLRGG
DGLLYFGGTEGVDVLDPARLSPRSLPARPAITAVTVHSTRRGGGAPEVRAGGAASVYAAA
LELGYDDSVLAFALTAIDLAAPAAARLRYRLAPLHQDWVYPQAPRTEFWVSRLQPGDYSL
EVQAAGRDGRFGPSRLLALHMPPPPWRHPLAHAAYVLLALVAAAWLAWRVRVAVRRERRR
AERLHRLVAERTAQLEEANLALVGSNARLEEANRRDPLTQVSNRRDLHDWLARECDGVQA
RLDRGDGEARLVFFMIDIDDFKHINDEHGHQAGDQVLVHFAERLRQLCREDDVLARWGGE
EFMLASCRLRMDDAAGLAERIRATVAAHPFRLDCGRVLPVTCSVGFAPWPLALAWPRLGD
SEQSVDLADRCLYAAKAAGKDTWVGIVAAPGAGRGCLQALLAGAAPDALAPGCVELLHPA
QVVPRFLRQPAGTGGGRAG
>A0A645GGW9|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MSQAFYDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIP
LSLSIGAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A645B095|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MVDMDNLKTINDTYGHDAGDEILKNTVDTIKAQIRLEDKIFRWGGDEFVIACRGLRIENA
VSVCEKWVKAVRESGIDHDGNRISTTVSMGISYFRPDDKESTDVIDRADEAMYRAKRGGK
NRVELAL
>A0A645GGB5|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MQISAARYANPLTQLPGNVPINEHVDRLLAAGSPFVAVYVDIDNFKPFNDTYGYRRGDDV
IQTLARLLCEQVDERLDFVGHIGGDDFFVIFRSADWEMRCWETISRFAESVTNMLGVDER
LSGGYMAENRRGELSFHPSPTLSLGAVRVGPGDCESHREVAAAASGAKKQAKKRSRSGVG
EPAGGCLFIERRRLGDGASHLFARPLVN
>A0A3F3S817|diguanylate cyclase|EC 2.7.7.65|Tissierella praeacuta|TrEMBL
MGTGVFNKKQGFIKLKGKIERYHLEKKSISITFIDVDKLENINDKFGHCEGDRLINIIAT
IIKNIRKEDFVYRYGGG
>D2Q8C7|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)|TrEMBL
MTRILIVEDEESYREPLVYQPTREGYDVSAAATGEDGLELFTQGGVDLVLLDLMLPGLDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARVRAVLRRNQ
MVAESDSASDDDIPLVCGDISMKIGQHEVSVRGENVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRSKIEEDPAHPKYLTTVRGLGYKIDAPIE
>A0A822PJT3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MYMHVDINGAYAAFECAMDPKLAKSPLIIASNNDATIIAMNRLAKNTGLKRGMPIFKCRD
LIEQHHIAVRSSNFTLYEDYSNRFHETLEGFAEDTDRYSVDESFMLLKNMDKIVDFEEYG
CLIRRTLLHNLSLTCGIGVSTTKTLAKLCTYASKRWAATGGVVVLTDPFRIKKLLSLIST
REIWGIGRKISERLAAYGIITACDFYDSDVRFLRKAFGVEMERTWRELHGESCFRLHESP
PVRQQIIVSRSFGQRLNTFSKMHEAVSFFTGRAAEQLRNDGSWTRQITVFIQSSPFARAE
TRYSSCGIEPLTATQDTRDLVSAAGAILTRIYKPGIDYAKAGVMLSSMTDGTEQLSLFDE
RPARRGSEALMKVMDRFNKEHRGSLFLACEGIHQDFRGKQAMLSPRYTTRWNELLVVKA
>A0A127SQ43|diguanylate cyclase|EC 2.7.7.65|uncultured bacterium|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7R9R8X4|diguanylate cyclase|EC 2.7.7.65|Candidatus Methanoperedenaceae archaeon GB37|TrEMBL
MAVLDLYRIEDGNKIQEQLINEVYELRRQVAELKKIVIEYKKLEEKLKYLSFHDSLTGLY
NRNYFEEEMKRLNTTRKYPVGIIIIDIDNLKFVNDTFGHVKGDELIKYVANILSSIFRKE
DVVARIGGDEFAVVLPNVNEKIVQSLCKRIKDNCNRNNNPLKVSVSLGYDIQYGQYKDIK
EVFKMADSRMYKDKNGKKWAGS
>A0A7V8HPN2|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSSAATGEEGLELFTKGGIDLVLLDLMLPGIDG
IALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
LSGEGSGAADDDVPLVCGDISMLVGQHQVTVRGENVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRAKIEEDPAHPRYLTTVRGLGYKIADPE
>A0A0J1IGJ4|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MIFSSALYLFFIAVFNTFTTHILLTRKKSIIFCINAFIITTICAYITNILAEKYIHNPVL
LEYVLYLISCLYIVYIHIVFNESISKKIFAMFSIWMFSTICLVVSVKIAQIFTGINEIKY
NLEIIYFLRECLQIILLLITYFYIRSPYKDIFNKVSNKTIGFMSLYPLFAFLLLINNYTT
SISGLKSLDYTLNMLFLLVFIIMGYVFVFSGISSASRIISMQYRMERLEWTSRSDPLTGL
YNRRYIMEKIENEFKRPKKKKFSLVIADIDYFKKINDTYGHDCGDCVLQMISKSLMDNVR
EQDLVSRWGGEEFLLLLPETEVEGAYTLMNRIKKIIGEQIIEYNGNQVSITMTFGIADSQ
DYQLIDDVIKKADNALYEGKGRGRNCVVVA
>A0A0J1FP30|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MLSLQNYFDVVGLSISVSILLTIKKIRKIDTLARWGGEEFILLLPETTINKAVVLGEKLR
ERLSRMDISNVGNVTASFGVAEYNSGDTVDTIVQKADDMMYQAKSAGRNCVRYIENENKY
FVLEIFTLNSLGLIK
>A0A8E6EV35|diguanylate cyclase|EC 2.7.7.65|Telmatocola sphagniphila|TrEMBL
MSTDNRHKSTVLIVDDEPVLRNMARTTLASDYQVYLAESAEEARETCLRNHIEVVICDQQ
LPGLQGIPFLEWVKNHDPRTVRILMTGLFSLERAVEAINDGIAQRFLFKPWRPDQLITIV
RNASHLFHLERRNEQLLDELKRLNSELEQRVIDRTQELQEANKQLHSRNHMLQRMALTDA
LTNLPNRRAIDRLAKNEMLRRARTPSPLAIALVDADYFKDINTQYLLPGGDHVLKWLSQT
LQNAIRTIDTVARVGGEEFMILAPDTNVEGARILAERIRSTVEISHTTYNGHKIQITVSV
GMVVVDSLVLAGYDQMRETAASALSKAKKTGRNRCVVQVISQFGGPSST
>A0A655WU27|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLKHVRVIVPLLVLLFSLLLTVFVVYTAYSLQLRHNRTLLENLADRQTMALQQFVDGDIH
FIGSAANFFRSSTSDDWVRFHTFAEETLKGSQSLIALQWLVKVEPPQAETFTARMQQRFP
EFTLYTVPKTGEIKYGFGTDDQAKYVLSDIYPLNYDNRKLLGFYSERERFKRILADIVVN
RRPNVSDKVRLLQDGIDKSIVKDGMLVYHPVFSSEDDRSLLGVMVGVVRLSTYFEKLVQI
SVMEQDLDMRVIDTGFDSEDSPVLYQSPMWRADDEPKIERKLVLPNRDWVLEFELHQPIN
HSEEWVLLGLGLGGVIISLLLSYIMRMQLEEKQRLTDMIEERTAELRYLVEHDSLTNIYN
RRFFSQHLCKMLDEKQSFTLISFDIDRFKQINDSYGHLAGDYALTHVVDVVKKELVESDI
FARFGGDEFAILSSVTDETALYTYLERIRKVVEAEPVMLNAETPLTLTISIGASINCEYS
EPEILQSVDDQLYLSKSKGRNRVSIAQQCSKVESNYAFNSGRMFDFM
>A0A109LD46|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKQKRTLGTPRLLGIVWPFIAVVLFQALLGCVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LTLYADNRNDATYLKYQQAIAVPQGGHELRIALDRPNPDMEAARLGILKGGNHPDDVSSL
IWLYLNFRHFSYLEKAIELWTVGDGYLLQLDELAQEMHGAITSGYVSSDDVHSWKARITA
INEGVTPAAKAFSDALGEGSRMILRLLLITNLATALGLIVLALLRTHKLLAQRHAFADAL
QAEKERAQITLESIGDGVITTDVDGAIAYMNPAAEALTHWRSEQAQGLPLAALFKLLNEN
AEPDGFTLIEHIVKGQFSGGSEHSKLIQRLDGSTVSVTLVGAPIRSAGKISGAVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEFRLEQVLQQVARQQSGRHALMFLDLDQFKLV
NDTCGHAAGDELLRHICALLQSDLREGDTLARLGGDEFGILLENCPAPVAEKIAESLRHT
VQSLHFVWKGRPFMTTVSIGLVHISQTPTTLETSLRAADMACYMAKEKGRNRVQVYHVDD
SELSLRFGEMAWVQRLHIALEEDRFCLYAQEIAPLGPTDAGNGHIEILLRLHDEAGRIIL
PNSFIPAAERYGLMTSLDRWVVENVFKIIARCMHERPGRPMAMCAINLSGITIGDDDFLG
FLRQKFDSYSIPPEMICFEITETSAIANLGSAIRFINELKALGCHFSLDDFCAGMSSFAY
LKHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALLEI
GVDYAQGYLIERPQLFTFDSLQCRPERPQPLLFKAPGTFR
>A0A655YJW7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDTDNRWRIALRSIRGELIIIGMIAVSIVLINTPKLLFEDKIHAYEKEQLQLTVELQKTR
IDYASLILEHLETHSLTPQLQEFFNLYHGNLCVLDENSPQQCPLSIIDAVQSTTSASDFV
ASTSVNITFAEGSILFFQVQGKQIRVLWFNHASFWPAPQKNISLVLVRGNHIQFLDNPIA
HYNALLNYTILRHRDDYGTLQFENMELSFLRWNLGEYQLISVFNDKVRLFNLIYWVMSAS
LTLLLTLTWFLTRLNLQKVAAQRHVYIDNLTRLNNRHFLNKISTKFIEHPHSIAAMIDID
HFKKINDQYGHITGDRILQAVASCLRKNVRDGDTIIRFGGEEFLLLFQAHSNKEAWYMLD
RLRQRVKDDHSLYGTTISIGFTFIDGSLPAAISRADTALYQAKEAGRNQVVADSEKENDS
AADLPIQC
>A0A7Z8FHT1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPERTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
SLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESKKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A377RT07|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MRAALSESGLEPDLFTVEAAALAAARRMHADANASGAEQRRVLGELIIHYERLMRETRRL
IGRSDRAERDMHLLNRQLQTLAGQLEYRATHDPLTGALNRGAVIDHASRCLAQGDMALIV
LDIDLFKQVNDDFGHPAGDGVIQAVVDCLKGLLGQETAIGRVGGEEFSVVWPTSSRDDAA
QVAQRICETVGRQRHAAPITRAITVSVGLSWNRAGTPFETAYSHADQALYQAKREGRNCV
RQWLES
>A0A377RV72|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MLPLHRNSLIAAALALPLFLFLYATLGHPKPIAIWKWMDIVCEGGTAVMAGIWFLFTLSS
RPRGLVTSLIAGGLCAIMLGSWADCLDEFFAVDKSAVWDNWLEGLIPFGMLLVTIGMYYW
RQEQFRLNEHLQKRERLFRDHRAFDRITQLADASYLRTQMRLEQERRPGLDCALVLLDID
SFHLINREYGHREGDRVLQAVGHMLLLNLRNDDLLCRYAGDRFAVLMPGVSREDGAVKAR
HLCAMVGQMRHHANDNREIRLSLRHACSLTDGVPEVVLAELSRAVETPGRSASSRAGTAA
PA
>A0A3T3G8A5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Braenderup|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1C5T4J5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MDKDKGVFMTAREVNMEIEMLKTVFDIVRLVDVSRTAPVNIGSDDCSYEAEHKCFAVWNK
GRRCENCISAKVFARKNKMTKFEFVNDDIYQVIAKYVVIDGTPLVMEMVFKMTDKIFLGA
YGSGSLIDKISRFNRELYEDPLTGARNRRYFEEQLKSLDKMGAIAMIDVDNFKQINDSYG
HVAGDAALCTIVRTIFEHVRADDVVLRYGGDEFLLMFEEIPEKVFQQKLEDIREEIAMAD
VPEYKEIRLSMSVGGVYGSCKVRDGVMEADRLLYQAKRQKNCVAYKRI
>A0A0D1JYG3|diguanylate cyclase|EC 2.7.7.65|Staphylococcus aureus|TrEMBL
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYL
IHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLK
QNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>A0A8B5A758|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGSRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2T8MNT2|diguanylate cyclase|EC 2.7.7.65|Salmonella anatum|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A232CRB9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MLACPLPPDEALRQQALDDMALVDTPAEHYLDALVELARETFGVKTVLISLIDHDRQWFK
ARIGLDAEQTPRDLSFCGHAILASEPLMVTDASRDPRFHDNPLVTGPPFIRFYAGEPLHA
SNGQAIGTLCLIDPSPRLLNLREGRQLNRLSILAEGYLQLRSLTEHTRFLRQEIDREQRK
SLLDPLTQLWNRAGFHALHQHELELARASDQRIGIIYSDIDHFKRINDTLGHRAGDSVLR
EAASRLRAALRPEDLLARFGGEEFVAMVQVRETTELTMIANRIRELMEATPIDCAGTSVP
VTISAGCTLAGSGEEPEQALARADAALYDAKRAGRNRVVSV
>A0A7M2ZRX2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPSTIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G3EEJ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLACLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A1D7XB76|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MVQNGLVTFVNQAALAHMGYTAGELLSRSFLEFIHPEDKESALQHYRELLEKKSPLYACP
FRIYAKDGSVKWVETNSEIIEWEGKPATLHFLTDITPRKILEEELQRLMAEKSLILDSLT
EMVAFLDRDMHVIWANKTASQSVGKSPESLFGAKCHEIWQGKNAPCPGCPVVRSMETGQV
CAGEVTSPDGRFWRITATPVKDKEGKIIGAVEAALDISESKRYEEQLKFLSLHDSLTGLY
NRAFFQEELRRLSGSREYPLTIMVADLDGLKLVNDTLGHAKGDELLQACADVLKTSLRRS
DIIARIGGDEFAAILPKTGEKTGEDLARRIRSTVEAHNKEHPELPLHLSLGAATSRSAAE
SLEETFKKADDLMYRNKLLNRASARNQIVGHLLAALKEKDYITAGYAERLQELCLKTGEK
LGLSPQQMADLALLVQTSDGQIPE
>A0A2R3IRB9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MDDLPSIPEDPQEAALALLHSRAEVARLKEREQLFSALLASVNSVLWAYDWQNRRMVYVS
PAYEKIFGRSAALLLADYEEWRNSIYPDDLDYADSSLRQVLERGAVEQREYRIVRGDGEV
RWLNDKCFVSRQGEAGLPLMVVGIAEDITDKKRMESELQRLATTDVLTQSSNRRYFFDSA
EAAFKECRREGIPLAFLLLDVDDFKKINDRFGHQVGDQVLQRIAQSGSAALRRGDLFGRI
GGEEFAVLLPGCDEQTARQIGERLQREVQRLRFQEGEQSFGITVSQGLTVLQADDEGLGA
LYSRADAAMYSAKRQGKDCIVVG
>A0A3U5N720|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W6XD72|diguanylate cyclase|EC 2.7.7.65|Rhizobium cellulosilyticum|TrEMBL
MTARILVVDDISANVKLLEARLLAEYFDVLTADDGYKALAICESTPLDLILLDIMMPGID
GFEVCERLKANPKTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDVQLISRVRSLV
RLKALSDELRIRADTAHSLVIEDILRGADGRDDIGQILLVDGRASSQERITKALKPVCNV
VAMSDPQAAIFEAAENSFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILLAAEAGAED
MIVRALDLGVNDYIVRPIDPNELLARTLTQIKRKRYNDRLRMSVKHTIELAVTDALTGLN
NRRYLDNHLKILFNRAAARSRPLSICLMDIDRFKSVNDTYGHDAGDDVLHEFASRIRSTV
RGADLACRYGGEEFVVVMPDTDATASAAVAERLRAIIEKTPFVLKNAGTAIELTASFGLS
CSTGDADTPEQLLKQADQALYKAKADGRNRVVANAA
>A0A0M6WPE3|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKTIIKYELVINKALRSALNYDTPDEQINEFIRFFGKHIGSDRIYIFEDCDEKHVTNNTY
EWCADGIVPEIHELQNVDMDIIGWWYQAFGSEKNIIITDIEQIKDEHRESYNMLKAQNVK
NLVVCPIRYKDEIKGFFGLDNPPESDTLGLTTFLDMIGTLLISLLKLRNSFTKSNKEAKL
SSYSSLSSIYISMAVVNVQTHRYHIVKTLDEVTHFLGVKPQKEGEYKIDEDFPGHINSVM
NEFCTKAHRKEALEFVDITTVEDRLRGKNTIVHELIGKVSGWCRERFIPVDYDDDGRLWH
VLYCVENIDEEKRRENRLMYLAQTDFMTGIRNRGSGENKITEYLVRKQCGLLCLLDCDKF
KSINDTYGHVVGDKVIIAIADTLRKSCRDDDVVLRLGGDEFAVFIPGMLDKERAEAFFDR
LFSNIEHIDIAEMNGKHILLSLGACFYDGMDCITFDQLYRRADTAMYDSKKKQGYSATIF
DAKQ
>A0A379TYZ0|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTAEKRHAFCAAFETINGTHGVNLTRHNYPALHGTLQTAATRCTDN
LDDVFLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDLDSGKEIIINQSKNNLFQYVNYNHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDKLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRS
>A0A419IJW4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQERKKK
>A0A174A5T3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium adolescentis|TrEMBL
MTVVTLFNIAMELWGVLICIVCAGGVYVGAIRRTRRTYTKVSMQLLCALMLLADVSAWYH
NGGCDKLDFYMTRIGNLGEYLINFIFIALFANYIWQTVSGDDMLENVSPHEWRARTSGGA
KRNRKNQRSANARSKPKKPRSKKLDVIYAASALGIVLTIATQFNHMVYYIDSQNYYRRGP
LFAIPQILGLVELALIVMLIIENRKNLSRPLFVTSLSFFVLPIVTTIVQILHYGLALQAI
AITISIQFTFVVDTIEMNKKIRSQDDAYQKASYEAQHDGLTDLWSKSAGREQIENYFAHM
QEDDQAVLIFVDIDDFKQINDTYGHKVGDFWIREVAQTLKRLYRHDDIIVRFGGDEYVAL
IKNTANERVIESTLDLFRRQLAQASAQYGQDVHCSIGACRVLSGKNVDLNLCLGFADHAL
YQSKREGKGMYTVVDYDSGKVQAA
>A0A2I5HJS3|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5X9WD35|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Albany|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A381G6F8|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A173Y4W7|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MTNFGEHYNEELAQQESEINKRTLWEMVGAFIVLTAVWGLAFGRFPTVNAIVFSVTYAIS
TGFFIASVILFFKADPSDERMKNFFVTGICIISAAMNLMFSYHMVLAYVFPLIVAVQYKE
KSVLWLSYALEVFLMPVSMIVGFYYGICDLNLLLQGNHTRTWYLAELADGFSKIPFSKMP
VVVIVVYRILPQLLILFVFVMIMQHTIGSMREDAYRIAELTYRKEVDSATRLYNKNKYED
MLANYYTMVERVAVVLWDINNLKEINDRMGHGMGDKLIETMSGAIYAQTDSRKKAYRIGG
DEFVMLIENPEKQEAEQIIQNVRDTLARYREEGGLRVSSATGTAEGNGIDILKIIHDADE
RMYEDKKRGKESREYAMFYSE
>A0A1V4ILY2|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MNFTRFDKKSIIFKLTSFVIVIIIFQAILLIATIVLGGVLSQGKDIAYSSLSDKVSNRKD
YMQREMSNRWINMDAYVSEISKSISKNGNNEIFFSDAAKYLISMLRTTQTTGVFLILNDE
NNKGEHSALYLRDYDPLFNDYNNKDLYFLIGPYELAKEINVPLDEDWNYRMKLTEDNEDF
YRKPYEKAYLSNDSKLLSYWSVPFKLFPKDQQIITYSEPFFDKDNNLRGVIGVEISVSYL
TQALPATDLQQKDSLGYLIGYKRKNEDEITPVIMTGALQKRMIDSDKKISLTHISPEKDI
YRIENSNSKDDIYGCIEKIGLYKSNTPFEEEEWYLVGMMTEHSLFSHVLKIKNILWISLS
ISILIGIIGGYIISYKFTKPIIKLAKQVRESDKSKAIRLEATGLSEVDELSSTIQFANNA
LLESTVKMSQIIDLVGVPIGAYEYKEERDRVFVTDQLKVLLSIDDSEMIKIVSDKALFIE
KINKILSRQQEDGVYIVSEAPDKYVKFKTVKNSDSTIGVVLDVTEEIIEKNMIKEERDYD
PLTKIYNRKAIQIRIQEMLSNIETLGTCGILMFDLDNLKTMNDTYGHKWGDIYIKAAVEQ
LKTIGNDKKVLGRRSGDEFVLFLYGFSNKEELKALIDNFYMNLENYPLILPDGKVKTVTI
SAGLMWVESAELTYDELLHYADEALYKAKKSYKGTCCIHESL
>A0A1Q8ZYS2|diguanylate cyclase|EC 2.7.7.65|Rhizobium taibaishanense|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGFKALDICERTQVDVVLLDVMMPGLD
GFEVCERLKSNPRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVKDLQLISRVKSLV
RLKTLSDELRMRAEAAQKAGVDNLESRLEEIGQVLLVDSRASSQERIIKALKPVAEITAM
SDAQAALFEAAENNFDLVIVSGALEDYDPLRLCSQLRSLERTRFIPVLLIADQGEDTMIV
RALDLGINDYIVRPVDPNELLARTLTQLRRKRYNDRLRNSVQQTIELAVTDVLTGLHNRR
YLDNHFRVLFERAAVRKRPLSICLVDIDRFKQVNDTYGHEAGDDVIREFAVRIRATVRGA
DLACRHGGEEFVVVMPDTSLDMAAAVGERLREMIQQRPFRLQGGAEISITASIGIASSGP
DTTTPEQLLRNADRALYQAKTDGRNRVVMTAA
>A0A3T2UWM0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8F5ABD2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MSLQAVRPKILGFINEQASAWLVALVVLLAGFALTAIVAWAASDLYQQQLRQRFQLLVNE
RYTRLQERFEDQEQRLNSLRRFFVNSDDVSHEEFDGFAQPLLLRTLAYSWAPRVYREQRS
QFEQNVSERGGVPFVIRELNSAGELAPATERDEYVPMLYSQTQNPMGAPLGFDLLAQPLR
RSALERAQKTGKLAVSQPMQWVGVEPAYATGVLLVAPVSHLPLSGQSQNEPYGYVMAVIS
IRQLVADGLPKPDRDNLMMQIVDTSDLHMRVLFESGTFGASKNDLVGTRRLTLGDHVYAL
NLRPSQVFEQANHSSLSAILTMGGLLSLLLSALLYVLVSQRQRALKLVEQRTVQLRMREQ
ELRAAHGQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFEAEQVVGTHTLESLHLA
VELEARSATLSVALGKRIPASQAMLVESPDNLHEAREWTLVREDGSQLTVNMLATVLLDD
HGLWIGHLAIYLDITEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPQNNWKFIYASD
GMRDIYEIEPGVLQQDAKRVFERIHPQDVERVRASIRLSALQLSHWREEYRVQLPQRGLR
WIRGEATPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLRAE
MVKLNRTSGALSVIMLDIDHFKRINDRHGHAVGDGVLQELCKRISQRLRRTDVFCRLGGE
EFMVLCPHTDGEQAYSLAIELWKSLRSAPMEPVGTVTASFGVASWRVDEGVDGLLLRADS
AVYVAKQAGRDRVEAERLRA
>A0A5I5LQS4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Uganda|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379S9W8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MTGILALSALLLAWHGKYGQKRINLPFISILFGGLWATHIALKYPALGHYDFSFLLISLL
SVLFIGSIAFSANIVAFTLYALPSVALCLWLNGNEQGLRILYLMALPMVGIAIQHIIQKR
YDNFAQQLMFKLLAERETLNSLSMLDPLTGLYNRRGLQSRLDTLQALDSHEHYVLLLDID
HFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTATEPQQARATAE
RIRQKVYDLKIPHMFNESVATNVTVSIGIAPLADRNIGDAIEKADKALYEAKHLGRNHIL
VSGDLHAM
>A0A2G4B0B8|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MASSFVTSSMFRFCFPLFLLAILFAGMNNVILVTDSNLGFASNLPYILLSVAVLLCHTFR
QGRMAMVSLTMLVAYLIIQVRLQTPLNTGTTLLELSLLAALVPVTCLLVYAFPDNGVNSK
SMLLYAIVLVLFMVWAQLIVSHFHAGGFESWSEGLLFIVRDFSKLPFVLVLYSLCLLGLT
AILVLVYNRSIDVVVYSTILLSSCTFIFFDVQYISSTMFSLSGTLIIVYVMSASHDMAFN
DQLTNIPGRHALEVDMKHLGRKYSMAMVDIDHFKTFNDTYGHDIGDDVLKLVARILRETT
GGAKAYRYGGEEFTIIFKGKYKEQAKEHLQVLISEIQNYDMTIRNSHERPDDHEVGIKNR
GQNGKPSEVVNVTVSIGLSDSTTTKHPEEVLKLADKALYKAKETGRNKLCVDS
>A0A0D6HKT1|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRINLRGLVLALTVFSAIAATANALYASYRLQREQLIANTLESNRVYAAKLAESAGGFLK
AAQRQLGYSARHIAAHMDSPGLLAAEVLRVQEQSENFNSVGVVGADGLILATTQNFRSFL
GTRVDSPGSRAALQARHPAISKPYVSIAGNLLINLSYPIFSTDGRYLGYVAGTLHLRKES
ALEDLLGRHHYTDGSYLYVVDGDGRLIYHTDPARVGEVVTGNPVIEAVIEGQAGARRVTN
SRGVDMLAGYAPVPASGWGVVAQRPTAVTLEPIRDLLWALLGYAAPLAVVFLLAIWWCAR
QISLPLSQLATNVEHHDVAVAMQRVKSVRAWYFEAERLKRAVIWSFTSLQEKIGKLNLAS
ITDPLTGLRNRRGTQDAVDHLQAAGTPFAVVALDIDHFKRVNDTYGHTVGDKVIQDVAQL
MRDCSRPSDILCRNGGEEFLILLPGVAPTEAVIVAERLRQRTAEREIDLVGGITVSAGVA
QWPTSGPEVLQAFHAADAALYAAKQQGRNRVVLHGTP
>A0A0D6H7R0|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MTTSLFFLVWGLATALALPLLLPFNARRVPGVRAFTIANALAVLSLLAYASAEILPPAVY
VMVSNTSWLVAVSLVYVGVRQFFGLRPQVLRVGAAAAVGIAAMALMLYVTHDLVGRMMLF
SGYTGVLMAATGAVVFRQRRGIRTPGVILYVLLSLSALVVLHALRAGVYGSGWAQAASLL
EPAPWGLFFIVCGSVTVPALFLALLLLIQTSLSEQMQAALTFDSLTGAYSRRSILDELEH
ELQRCARSGGRLAVLVLDIDHFKSINDRHGHAAGDAALRHFAQVVPKAVRASDSFGRLGG
EEFVLLMYGCDAAHALVQAQRVCDALRDSPLYLQGQELRMTTSGGVATLQPGDSADGILA
RADLALYKAKELGRDRVEMAWSARASGRPQAAREEEAAAEAAEPAKLTA
>A0A728LKY8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:d:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A344QYT9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3Z6QK58|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A380UIU1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter haemolyticus|TrEMBL
MISSLYQSTSLHALFRKSQFTIFAITFFICSFTFATISMFTMETYAKQNLQLLSQTVLER
IQPAVVFKDKGTIDQILSDYTTSHAIRSIHVYDAQKQLLAESSKTIEYTSFLQDLLDNWF
LHDPVQLTVIHNKKQVGELVLYGSSENILHFLKTIIIGLAISMFFIVIALLWSVNLTYRQ
IMQAIKPLTHIAQLVSDQKAYNLRFPNNHIREFQNLNTVFNELLEEIQIWHTHLQKENHQ
LSFQAHHDQLTGLPNRHYFYDELNNIFDNPQYRHNSALLFLDNNKFKAINDQYGHLAGDA
VLTEMASRLKLSVRHEDFIARLGGDEFAIILHAIHQAEHLETIADTILASCKEPLDFNGQ
SIHFSFSLGIAFSQFAENPEDLVMQADQAMYKAKNLNPHWFLYKPEN
>A0A484URV7|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MADIAATGIHLPSMPYQSAPTELLATTWRRAQARHEPGTHARLRDLVAEHRTTLATRFYE
AMLESPSASRFLSHQLVQTRLHAALQRWLDTVFDIAFNARYDEAVAFQRHIGEVHARIGI
PSHLVMQGARALMMDLHALLGDAPVAERAQALACAVDTIGQATEIMCHAYDTFHERNTRA
EESYRLFVVSQDIVSEKEKQRAALLDWENTFVYEIAVNGAGPSLPRLGKSEFGMWFLHKA
AHAFEGSKDVENILAQITQVDEAVAGLADTPAQAAIPVLKTVREQCAAIRFLLEGLFAQA
AHLESGRDTLTRLLNRKYLQVVMAREINYVRQKASHLSVLSIDIDHFKGINDQYGHDGGD
AVLQHLALFLTQSVRSGDYLFRLGGEEFLIVLVDANEAQAIAIGEKLRRRAELERIALRD
GQTLSVTLSIGVATHDGHPDYQRLLSAADTALYGAKRAGRNRVLANSAL
>A0A398Q3N3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A615FWF2|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3S4J7E8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIMVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A1J1EH29|diguanylate cyclase|EC 2.7.7.65|Lysobacter enzymogenes|TrEMBL
MSDPIFPGPNEPHPHLRQHRLVVLLVDDQPIIGEAVRRALASEADIDFHYCAQAAEAVAA
AEALRPNVIMQDLVMPGVDGMTLVHHYRIHPVLKNVPVIVLSSKEDAVVKSQAFSTGATD
YLVKLPDSIELIARVRHHARAYLNQIERDEAYRVLSEHQQRLLELNETLRRLSDVDGLTG
LNNRRYLDSYLETEWRRALREGADFAVLMLDVDNFKLYNDYYGHLAGDEVLKDVAGVMRR
TVQRPADLTARYGGEEFTVVLPATSASGALQLAEQICAGVRALSLPNRAAPSGLVTVSIG
VAASSPAQGERYAPLLRVADMALYEAKRAGKDRAVYRTKDE
>A0A3Z2GMQ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>G3FT03|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A3V9FI47|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V9RY32|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MFPKIMNDENFYRKAVEQAVTPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5I5ZFP6|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6G4MNE4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAIIAGVWMGLTGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSMGTPVVLTSEPLALWLTLPVLVVY
PILFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A5P3HVS1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGVGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHQQGG
>A0A5I9FEW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Brandenburg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1W1T1T6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A486LBV8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKSEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNYGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEKIHTERSAIM
QDADERMYEIKKGKR
>A0A486MTB0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVTRGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A0V9LZV2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A244BM70|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEMHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3V7IG37|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weltevreden|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F7SV94|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGSAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>C3SDP5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGAIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQGNALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A369FL80|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A241QVC1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A5J1R452|diguanylate cyclase|EC 2.7.7.65|Salmonella muenster|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0A1AA82|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKADNDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIHRV
>A0A8G9R6P1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQASDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A827DT65|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCQRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A2X5EQL9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQAPGIPENEEQRLKSLYITSLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A2U9KQ28|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILAALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A1D7Q375|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A6D0CCV1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWNGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A400LA30|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVYDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A368IU61|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0K4YF22|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A4Y8A2G5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEAAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3V9PS82|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bredeney|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2A7M3C1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENEILDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDGKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0K4RIN5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGLGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A0V9S5A9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5C5HHL0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G2ADB4|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDTRMQPWQLFSTRLGIAAMLISPVIVASSVEAINMLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRHLVGEQGMVARIGGEEFAVAAVVDSAQQGYVLAEKIRHGVESQPFGLGQHPI
HLTISMGLETREVGHARITELFNQLLLAADDEMVKAKQTGRNRICMPALTESAP
>A0A736UR98|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTCYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1D9LMK3|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MKSKRLSDSIIIRLLALSLAIMIFGVLSRYYALGSFLRQDLGQVVSEQQLALAGYVAHDI
DDKIRQRKALLSRLATALPPELLDRPDALRAWLKERYQYQPLFSIGLFVVRPDGRVIADY
PEVPHRMQVNYGDRDYIRQSLQGRFYIGKAITGRSSGVPVLPMSAPVQVSGEVPAVLVGV
TAIAAPGFLDLLQQSRIGDHRDSFLLISPRDHQIITGSQSELTLQPMPEPGRDPLHDQAM
AGYRGAAVAATPQGEEEVRAIVQVPSTGWLVVAKLPGRDAFATVARVQHFTLRQALIAFV
VFSVLACGGMYIVLRPLFRAARHADRMTRGELPLEPLPIHRKDEVGYLIASFNRLLRKLE
DKQTELAQMAHHDSLTGLPNRLLLSDRLHVALAQAQRRETRLALLFMDLDSFKMINDTLG
HKAGDKVLWQAAQRLSGTVRQSDTLARIGGDEFVLLLSDLDDKAEDIARTVADKCLEAFD
TPFLVSGNSCQLGISIGIAIGDGYSNPDSLLQAADQAMYRVKKTGSSGSATIHL
>A0A5I2CYA0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mikawasima|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A622HHW6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKFADMALYKAKN
AGRNRTEVAA
>A0A246KIU4|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MNPLADQTIAPVSEDELHAELARLRAEVAGLIERAERAEALADHDVLTPVLNRRGFMTVL
ARNLAYCRRHGVEAALLYLDLDGFKGINDGLGHAAGDAALIAVAELLLANVRESDAVGRM
GGDEFTVLLMNAGAEEGREKARRLSEALQSEGFIWDETRLALGGSFGVRAYAEQADAEVW
LSEADAAMWLRKKARPEATR
>A0A5T6NX77|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A758C7G2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A486WV96|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y4VC31|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3Z7J8Z0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPRAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U3HP26|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEIAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V5H931|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERNAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A754D8F4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQIAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A764MT98|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHEQLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0H3YR43|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MRGPSPLEQEVASLLADPQFEGHPLKEALSQLWSAHHDLLGRIERIARVSDGYQSIARER
ELSLAARFDKQLRQLEKVARISDRYQAMMQDLNASLREASMLDSLTGIANRRLLTERLRE
ESERAKRYGRPLALVMLDIDRFKIINDDYGHDVGDRVLIEVVRVMESEIREHDLCGRWGG
EEFLILMPECTAQMAQTVMGRLGASIAALGVRVNEDLLGVTASMGIAELRPEETYSNTIN
RADLALLRAKRSGRNRCELAD
>A0A615E3A9|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRLGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Z3BMP1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDNRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A4U8KJI0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379Y1E4|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MNARSYQELLNSKQRLALFLFLIMNAASSVFTLLFPFRDTPAFTLPLLCIPLFCLVAALF
SLQTPRKYLCKLNLFASVLGLLWAAHIYVKSQYCLPNNQDFLLISLFSIFFISAISLTDN
FTAFCLHAVPSAMMILALDGMHNTLRILFTTLLPIIAFSIHHLMLKRSEIFTHALVANLY
NERDKFNNLSMLDPLTGLYNRRGLENKITMLLEPQTGRHYVLLLDIDHFKVYNDSYGHAM
GDRALVQVAIAIRDAVRSRDIVVRYGGEEFLVLLTNVHEGYAAQLAERVRQRVAELNIPH
GASPQHSGTLTLSAGISALERLDVESAIGAADAALYLAKHSGRNNIQLAQNVEPALLQPQ
ELTH
>A0A7W3B8J6|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RHBSTW-00215|TrEMBL
MDKPMWVKKLRRVLSPGYVVNLCFFIVFCFSTLLIWREVKILEEAYVANQRNNLENVTHE
LDGLLQFNIDRMIFFRNGMQSALGTPLDFAVLRKAEQDYLEKRHEPIWSVEIHNRRTLPV
YGVADAFVDSDDLLSRDTPFSGNELMASLELGYLLRLANNNRGFTERMLYVSRSGFFITT
EPPKNSTQALGLYSRAISASWFIQQTQRNNPARGIVWQTFPGDEPQREAQVVTASIPLDY
QRYWLGVLAMDFSVREMRTFLVNAVKNGQEGEYQLYDNHLNLIASSASDNVLTLLSPQEQ
EQLRSVFSHGNQGGIRLLTRYISWEKLRNFDGVLLRIHSLKEGVRDDFGRITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWRAWHDALTRLLNRGALFERASEATTLSERLK
RPIAVIQLDLDYFKGVNDRHGHQAGDRVLSLVGSTIASHIREGDLAGRVGGEEFCIVMPN
TTLHEAAAIAERIRVRINGREILLRNRSSLRISASFGVSSSDDSNEFNFENLQSIADHRL
YLAKQNGRNQVCAEG
>A0A8G1HUN4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MGGPGFRHDQDAFIAAQVRSDRLHQLFHQSFPAIFGSFLAAIMLCGLCWERFDHSVIFTW
IGLLTASSLLRLLMFMAWFRCPDSERTPQRWEKKYGVTLVLSAGIWGAGAFAVMPANDLL
AQALVMLFAVGMSVSAVSCYSAYRYMTLASIGLVLLPCTLWLLFQSSAIQVGMALAVIVF
ASFVASATRKLAEALETAFLLTREMERAHRIATYAAQTDELTGLKNRRAFFEHAQQLFHD
CQHNRLPLCAVMLDMDHFKHINDTYGHQVGDQVLRQMGVIINRSFRDTDVFGRLGGEEFA
ILLPDTSIEVALNIAEQLIQSIGGLMTGPVHRISASLGVAAMDIGDNDFQSLLNNADKAL
YRAKARGRNQVAVSE
>A0A517PEJ1|diguanylate cyclase|EC 2.7.7.65|Alienimonas californiensis|TrEMBL
MVHCPVAPPGAAELAGGWKPSRLVGGRPDLAVWGVFVVWPLGALTGAALSWPPGAGAVLL
MAIPAVWIGWRLSGPAAGLFAAIAGLCCASEATLLRVMRRIGEWYDVVLPGPADDRLFAP
LAAMILIALVFRALRDRPEELTLHPRSVDPRRSGSGVGVLEQAASLLSLQQQDEFTVDLP
GASRSLDGVVRSVRATARGCLRCEHASVWLWDGLRLREAGPPSGSNVRTPVPDPRVGLAA
WALEHRRPITRQTLGMWVARDRTLADALASDPAPPAGIAPLLTRCAPGEGTDGGDEILLG
LLIVDQPQGFDPQFAAVLAALARFAATALENARRFDQIQGRARRDDLTGLLRRDPLLEDL
AAMLVPGHAQRRGHSVATVIGDLDHFKTFNDSFGHPAGDAAIRQAATIWRDLLPVGARLC
RYGGEEFLAALPDHTAAEAAAHAEKVATAIRAAGVTDDGRTLPMTASFGVAAADPIDTPQ
HGGAGAAADRLIRRADSALFAAKEAGRDRVAVVDVDGILIAQPVGPSVRKAL
>A0A031GJ86|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MSWTNLAMNGRILIVDDAMENIQILHQLLREEHDVLFALSGEKALEIAHNQLPDLILLDA
VMPGMDGYAVCNALRESAILSAIPVIFVTALNQPEDETRALEAGAVDFITKPFNAAVVRA
RVRSQLTIKRQADAMRELSLTDSLTGVANRRSFNDTMDSEWRRCARDGVPMALIMADIDH
FKDYNDTYGHQAGDLCLQQVSAALRRCAVRPPDLLARYGGEEFIILLPQETRDGAEVVAQ
RILDEVRALQIPHTRSSVGPHVTVSLGMASVMPTEGMDPSALIRAADALLYRAKHTGRDR
YCASEGE
>A0A653V552|diguanylate cyclase|EC 2.7.7.65|Nocardioides sp. AX2bis|TrEMBL
MTADALGPAGADLIDVLLEAATAMPWPEEEIDRRLVQWAADAVGATVTLGPAPAGTHGPA
ELAVPLHDERFLLARRETGSAGFGDLEHRLLLALAAMAATSARHAQREARLRRRALTDDL
TGLWSHGIFPDLLATASRRRDDGEQLGVLFLDLDRFKQINEELGHLDADAVLREVGRRLL
AALPPDSVVGRVGGDEFACVVRRLAGQDGLTETRTLLRRAVNQPIPVGDRLLSVDVSIGG
VVSVSPDEDPDALLRAAEEAMRTAKRGREDVAPPRWYDEKTLVRDLLDQGGVGIALQPMV
LLGSGRVVGYEALVRADHGHLGAVSPLLLVGSASRTQMLDELTEVVAAQAVETVAAIARD
SQTPQWLCLNVEFEQLVPGSGLVPALAAAVAGTDVRLVLEISEREIGRWTGAHDAVARDL
DQAGIGLAVDDFGGGHATFALLHSWPWRWVKIDQALVSARDDDSSRVLLGHVVTMLRDLG
LTAVAEGVESTDQQDLLRSLGVPLAQGTLFAAPATAALVRDAAATQLHAAPPDL
>A0A078LG17|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MPHETTPGNWSWLRTLARRFGPGHVVNICFLVVMICSTLLTWREVVVLESAYRASQRNHL
ENVANVLDRQLQFSVDKLLFLRNGMYEALVTPLDFADLHDAVAQFAQLRGKSFWQLELDR
RRTLPLNGVSDAFVNRTTLLTRDNDALANELSAALELGYLLRLAHSSTMLAQRTMYVSRS
GFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQRQNSARGVRWFSSPVPGGEVQQKVTVS
LSLDNERHWYGVLAMDIPVSSMKRFLEDAVEKDSEGEYQLYDYQLRLLATSTPEKRQVNT
FDDLELALLANDIEHDTHGGIRMGSRYISWERLDHFDGVLLRVHTLREGVQGAFGSISIA
LGLLWALFTMMLLISWVVIRKMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFERARVLIQ
RCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDRVLSHAAGLISGTIRSHDLAGRVGGEEF
CIVLPGTTLVQAAQIAERIRQRVNDKEILIAKGTTLRISASLGVSGAQENGDYDFEQLQS
LADRWLYLAKQAGRNQVCVRDDHPAPSPDTR
>A0A0X8HBL5|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MSTLRSRLLLGVSLGWLVLVAALLAYSHLSGGALAQRENLTHLEYEAQLIAKQLDRSIHV
RQQALARLRPSLVLDEDLFTQLQRQEGLLALFDRLMVFDAQGEPVAAWPPFEHGGPNIAA
RDYFHHVRGFRRPHVSEPYVGGETGIPQVMVIEPLLDDEGRFLGILGGNASLHDGTSFVN
LRSQRIGEDGHVVLTTAQGQIISHPDPAYLMQAVPAADRLPLLDRALYGWEGSGMGEQLD
GQPALMAFRQVWSADWVVGVFLPLSQAEAPVNRYATELRWVGLATVALMLPLLWWLLGLG
LAPLHRLERQIERVGRGDARRLRLHTSMRELHQVADAFNRLEDQRRDALASREAREAFLQ
AVLASSPVGMFLADMKGRINYVNPALEAISGFNVAASRTSEWVRRIHPEDRPAFIEQWRA
TLERGDDHHLQYRFQRDDEQLWLEAQVSRVELGDTALGFVGMIQDITERHERETRQLWEA
EHDPLTGCLNRRGFENRLEEACALHRRESDKVLSLIMMDLDHFKPVNDTAGHAAGDELLR
LIGQLLEESVRQQDAVARLGGDEFALLLPSCPLERATEIAERIRRGIETLEFQVDGHTFR
VTASIGVSNLSVDDRDGGPLVKRADRASYRAKHQGRNRVEVQAGLSKVSES
>A0A1M4MME5|diguanylate cyclase|EC 2.7.7.65|Methanoculleus chikugoensis|TrEMBL
MQKNPLNQQICAVRECISELTPGTPADSDDSASLGSLLRAAESLAAAATRVEEERQQLLD
LIGSSPDRFVVTDADGRIIDANPAAASLLGEPLPGTLLAAHGFPDVQSEIALMLADLRAG
KACAPRETTLRSRSGAPVRVVITAAGRGVGEKRWLIREHPESEEQDRLLARAEEERTLLQ
AIIEQMPEGVVIAEAPSGMLIHYNEQLRRMWGRPDMPRDLRMFRGVHPDGRPYLPEEWPI
ARSVASGEVVRDEEIRLLRADGTWIYINASSAPIHDESGIVRYAVAVLSDVTDRKQMEEE
LQASEEKYRRLFENTGDAINIFEMVRDEHGEIVDWILRDANPVSQRDLGRLDEIVGRRVT
ELFGAGVMAEYITRSREIMASGVGQKYENSFWGNRYYISSTIPIGKDLLGSVSTEITDRK
RMEEELHLQQQRLELALSAARMIAWDWEPAAGRLRISGDFAGIYGRPPFARPEERLTLVH
PDDIDRLRAEGEHNGPYHTEYRIIRPDTGAAVWLESRGEVQRDEAGDVVRAVGVTMDITG
QKQSRQALEHQQELLQGIIDAIPVMITIYDPDLRLFHLNREFQRVLGWSEEDGARGDLIA
RFFPDPEYRKMAGDYMQSLKPGWRDLLLVAKDSSIVETAWANIRLSDDTRVGIGIDIRER
KRAEATIIESEGRFRALMNASPNAVMLIDRDGTILVLNEVAAERFGRSVQELMGTSIFDY
FSPDVAARRREIIGEVFSTGRPVRFADERQGMVLYNSLFPIADAEGNVVRVAVLSYDITE
QRRSEEMRHQAFTQIEHNMEQFAILGDHIRLPLQVILAASELLDDEQASERIRKQVWRIN
DIVRQLDRGWVESREIREFLRRHELV
>T0PPK4|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MHNLFSSAQLLSLVLFVTLSHVGVAVIFAYVWHTQRRIRGLLYWSASELAIAASFCGLLL
RPLEGDISLANILLTNLLLLAAPLLYERGLRHFFRREADQLGWLCPAIALIGFLLFALTA
SLRPLSDVHSRIMVLSAVLSLQFAVLIWQLWRYQRLAPLYRVLRFAILLLGLQLLLQLLR
IAKHLWQPELNASTFTDPLLGPVILLSLLFTIARSYLLLSLVHTRQQQALLATQRELEQR
ANQDELTGLLSRHYFQQLLQAQVSAGANPCQLLLIDLDDFKQINDRHGHPAGDAMLRLVG
QVIRTTLPRQGIAGRLGGDELVIFLMENPQTLPHYCHTLQQRIAQATSQLAGGPISMSIG
LTSLQPGERFEQAYPRADRALYAAKQGGRQRTCIQEPHHSEPQLLQPLVTGS
>A0A1V5WDA7|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MPLVISVSVPRNDVLREWGQRVRVWLFVLAGVSVMLAGLGIFLWQSWKANIRNEMGMPHL
NDGLIRVNEMARLVTENSNDVFVVVSLPGLIIEYVSPSVERNWGWVREEFIGQPLGNILD
GETAERVGEKIAGMMQEIGPAGTGGRHGKIDIDILHREGYRIPYDVSMTIICDDRGKPMR
AVALARDLSDRKASEEIVRNMAFYDRLTGLANRRLLEDRLGFKPVNDTFGHEAGDWLLRQ
VADRMRSCVRGTDTVARTGGDEFVITIPDIRSAEEALAVGEKIRASLEAPYPFNETNTFE
ISASIGVVLYPDQGKDARNLLLMSDAAMYQAKKAGRNRVVLYTAGIVDTADAHVLSVAIP
WQESYCSGQPDIDRDHRELFRISNGLMPHLAAQESGGASYGNILIHLRDHVEKHFRDEEK
ILREHNYKDVQLHSILHRELLRAFDDMVKRHSEGSASIEELFEYITRTVIEEHLLMEDRK
FYYLFDSSAHGTAEQG
>A0A2D1QMK8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MSAQPTAPHYSTPLLALVSSIMDFPAPSEATPKEYDTLIQQLNQLCPLQHFGILGLSEAG
LHWVCEHQISDRFKLQLGLEESRISDQLDQLDEAKGWCILPVEHGQIQWLLACCQPKDLP
TLRLLLECLAKRLNETQAGSQLSELASPLIRKDPDWQKKIESINRIIRLANTLPSQALFS
QLEAVLRQILAIQDMLLVRIDSHRLEKIYPEQPPHSDEFITSLCHSTNNMEQHKEQLHWY
SQPLRLQQQYFAHFLISTQQPLETDNRLFLDFLRSQLTLLLELRRIRQQLHDINSEDSIN
QRLQQLRQTNLRLQKQLKQHQELERRLQFDALHDPLTQLPNRALLMNHLNHAMTHFHRYK
TPGFALIFVDVDHFKQVNDTLGHSAGDQLLKEMSRRLQTCIRQNDMVARLGGDEFVIYLD
NSKDEEDISPVLNRVISRLSYPFRLQGNELSITVSLGVASVSEQTSDISQLLHQADLAMY
QAKRNGRSRIVSYSEECSAQTWTSPEEMLARALREGRIVPYFQPVIRLKDSRLTGLEVMA
RWITEEGVLKDAFDFIPLAEQCGLIQELDYQILRHTCQQLKNWLPMSGQSKFKVAINLSG
KHLVNHDQIMRLVDIIESEGIAPGYLIFEFNERELSRQDSDALTSLHELRAKGIQISLDD
FGTGFSSLNALFHFPVDYIKVDDSFTHRMLQSPKDLALIRAMRDICQDLDFTLVVEGIEN
QQQLQKLIDMGCLMGQGRYISPPMPGADITPLLSQTKGERG
>A0A1V5WE58|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MASEYRKSHYRFILVFMLFLCAMSIMLTIGAVRNTRQVHAVETYNEIYEIKKVFLKNTVQ
NMVRTIENLYQFHTRTGELYRDRLFTDIDRLYAYNPVRFATRARELLVDTNYGDSLFIRF
TDTRDNTELYSLGSPDPESSQTRTWDRFALTIGISSKWIDERTVAAVREIIYQQEYENGG
YIWVNEVHDWNGGPDYATRRIHANLRDSEGTLLDTATTDVAGNTPYLTELEGVRKNGEVF
FTYFFRRMESRDIGEKITYATLYPRYNWIVAMGYYLDDVQVYIDRVEEASDRITGIIVFI
TVLSNCALFVFAFFLLSRRENRYFLRTRRQITEESNIDPLTGIFNRRVGNAFLEDAFRSW
HETGATPALFMVDIDDFKPVNDKWGHACGDEVLRTTVQAIRDSMRLSDKLIRWGGEEFLV
VCPGLSPEGSYVVGEKFREAVMNARTANCDQNERREIAVTVSIGTGFFAEGDHDPFEAVN
RADLALYRAKKAGKNCVR
>A0A1V5WD45|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MIQSKPRKTAVNHVLVILAWLILTISGLTLFINENANVIEKNSALINEAGKIRGGAQRII
KIHLSGKPVAMYLPEIEQSIDILFAHTRSANSFYGSYDEQYFTATLGSWEVLVRLIEQDA
PQDEILEQSEIIWYSSNALIAHIEHQTLAYTKRFNLVSAIFFTIVLVLLFVFFVTKHVIR
DKIEYGSTHDLLTGLYNRYYFQEALEQNYASSKRTGQGFALLMCDIDHFKKINDSRGHPA
GDRILHELGMLLRSVTRTMDTAVRYGGEEFAILMTTNTTAECEKYAERIRHTVENHRFRG
NIPVTISIGFCLYRSGMKREQIIENADKALYHAKEAGRNCVIDFDSLTV
>A0A1V5CIG6|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdaceae bacterium PtaU1.Bin034|TrEMBL
MTRRTLHRPHKTTQSQRSKMPNGGSVNEPSGNRAAIPRGPEGTTKRPDVKEMLRESKNLL
QLVFNLSTNFIYLSPDEIESWMQDVMRIVGEYAGVDRISVFLFNKDCLTAFKNAEWTAQG
FKPGREVAPVVSEKEYPWIFSKIKNLEMIHIPDVLQLPTEAGAERRAFLSENVNSMLSVP
IVHGFNIMGFLRFDGVANRKVWPDEITLLLRMVGEFFADALVQKQTDEQARTSALRYKSL
FEQANDAIVLIKDGKFVDCNPQALKMFRCSKEEMVGVPILSFSPEFQLDGVSSGDRMGQK
SSTVLSRGAQFFEWRYRRPDGTLFDSEVNLNQIEFGGETYLQGIIRDVTARKQWELALRE
SEERYRSLFDGSRDAIYITSGDGTFIDVNEAFLSLFGITREALRTTNAKSAYVTQADCET
FKKIIKEDGYVKDFEIRLKGNKGIMYCLITVNTKRNEKGEIVEYQGIIRDVSATKKSEQT
IRRLAYHDALTRLPNRVLFNDRLRVAMARASREKKRVAVMMLDLDKFKSVNDELGHKVGD
ALLKTVARRLGRVLRKSDTVARMGGDEFLIILPDIVDESDATIVAIKILEAFGFPFELDK
SPLSVTTSIGIAIYPRDGRDIETIVKNADIAMYYAKGNGRNKFFHYRPDMKSGEAFAGQS
AEHESNVTTLVPDRTVNGSS
>A0A5W3E862|diguanylate cyclase|EC 2.7.7.65|Salmonella anatum|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYLYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEWEKK
>A0A4R6DWH2|diguanylate cyclase|EC 2.7.7.65|Azoarcus indigens|TrEMBL
MHPANASPDPVSDYIQSDWLALFDSASPAARIAIRDVVLAHKAEMSDAFYARMLSDAEAH
PFLTHDEVNSRLRHSMQRWLETLFSCETHEQFGSAMAMQRHVGEVHARIDLPVNLVARGA
RLLKGEIARRLPGSGLDRNALVEAVLYVDNLIDLAFEVMSSAYVASHERAARIDEAYRVF
SYGQNMPLERERQRASLLDWENRFLQAMVTARSGDELPPIHGSTFGLWLQHKAVAVFEGS
AELPAIRNAMDTVDHTLLPLCGQQIDNGDRAEARRLVKEIQHQLAQLKFLIGALFERFVD
LESGKDALTQLLNRRFLPAILTRETELARNQGKGFALLLVDVDHFKRINDDYGHEAGDRV
LQQMAGLLLNSVRSGDFVFRYGGEEFLVLLVEVDRQHALRVAEKIRGRIEQELFLLPEGR
SLRVTGSIGIAMHDGHPDYQRLVNRADEALYRAKNEGRNRCVADPD
>A0A2X4Z2Y3|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MIWREIKVLEEAYVANQRNNLENVAHEFDSLLQFNIDRMIFFRNGMHSALETPLDFAVLR
KAEESYLAKRHDPIWSVEIHNRRTLPVYGVADAFIDGDELLSRDTPFSGNELMATLELGY
MLRLANNNRGFAKRMLYVSRSGFFITTEPLKNSTQALALYSQATSDAWFTRQTQRNNPAR
GIVWQTVPGDESPREIPVITASIPLDFQRFWLGVLAMDFSVQEMKAFLVNAIKTGEEGEY
QLYDNQLNLIASSAPGNVLTLLSAHEQEMLKRAFAGENQGGIRLVTRYISWEKIRNFDGV
LIRIHTIQEGVRGDFGSITIALMLMWLMFTLMLMISWFVIRRMVRNMSMLQTSLEWQAWH
DALTRLLNRGALFERATAAARQSERLKRPVAVIQLDLDYFKSVNDRYGHYAGDRVLTLVA
STIASHIREGDFAGRVGGEEFCIVLPDTRLKEATAIAERIRIRINSREILLGNSASLRIT
ASFGVSCSEDSSDYSFENLQSVADHRLYLAKQNGRNQVCADG
>A0A2X2US12|diguanylate cyclase|EC 2.7.7.65|Enterocloster clostridioformis|TrEMBL
MSGKENLTKIEFINQNVYHVRSTYVEVDGYPYLLELVVQITEETHMDHFNAINDTYGHPV
GDLALKQAAKAIKNCVKRTDSVVRFGGDEIFVVFGDIPFHMLQEKLEEIRSCVDKAVIPD
YPQLKLSISIGGVYGPGQVSDLMEAADRLLFQVKREKAGLKIKEKMNERL
>A0A518XDY3|diguanylate cyclase|EC 2.7.7.65|Pantoea dispersa|TrEMBL
MTVEMLTPQDTSPRPWQHALLLGGLAFLLTLFCLELIVVSGRISPLWYATALMTVVVFRA
PAKQVPLLLAGCVLGTTLANLLVIGPALSNVKFAILNMVQAVIAGLMLRALLDRHAPLDS
LADWARFALCAGLIAPLTGGVVALWMLHVGSGAALPFFFTWVISEVIGVLALGPVLLLWP
RRPLRQLITPGRQLETALTLAGTLLASYLVLRFMPWPFTFIVVILFWCAVRLPKFEAFLL
FFLNASFMSLLLALNWVQLARYEMLFGQISGWLPFLLVLLPGHAMSLVMDAFLREKQHIS
ESETRFRNAMEYSAIGMALVSPQGNWLQVNQSLCNTLGYPAEALKKLTFQQITHPDDLHS
DLQQLQRLVAGDILTYTLEKRYFRKDGEIVWARLTVSAVRDAERQPLYFISQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALLGLDPHVTPTYDVWLHL
VDPAERETVALIIQQAIERRSAFHLEYRVNLPQGTRFLRSEANRILSQDGQIERMLGICQ
DMTPLRALNDALFQEKERMAITLDSIGEAVISTDDEMRVTFMNPVAETLSGWSQEKAAGM
ALSELLNITRGASGPRVENLLLCQLPSEKTTPDLEEELVLHTPEGGRVEIHYSITPLKTL
AGHSIGAVMVIQDVSESRKMMKRLSYSASHDMLTGLPNRHSFEQQLRQRVSEAATGQSQH
VLVFLDMDKFKAVNDTAGHAAGDALLRELAGLMQQHLRSNDMLARLGGDEFGLLLPDSEV
DQVRDGVQRIVSAVNEYTFYWHGEPYHVGASAGITQIDAHNCHSNVVMSQADVACYSAKH
AGRGQYRVYQEVQM
>A0A7W7N5M2|diguanylate cyclase|EC 2.7.7.65|Brevundimonas bullata|TrEMBL
MSARILVVDDVETNVRLLEAKLTIEYYDALTCGDGLTAIALAIAEQPDLILLDVMMPGMD
GFETCRRLKDEPKTRHIPVVLVTALDGRHDRIRGLEAGADDFLTKPLDDVILMARVRSLT
RLKMVMDELREREESGRRVGVDTAGVARLKGSGGRVLVVDDNALQAAKVAQELAVEHRPL
VEADPVAALEAARGAVDLMIINVTSEGFDGLRLIAQARSKEPTRRLPILALVDAQDRPRL
LKALDLGANDILTRPVDPEELSARVRTQVRRKRYGDFLREKLDHSLEMAVTDALTGLHNR
RYMTNQLQALVARTNRGSEPVAVLVLDIDHFKAVNDGFGHDAGDEVLREFSVRLATNVRA
VDLPCRFGGEEFVVVMPGTTLEDAHRIAERIRRDVGAAPFRVMDGKAHLNITVSVGVAAT
TGADDTPESLLKRADEGVYEAKASGRNKVVARAA
>A0A0M7JV76|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MTTSLFFLVWGLATALALPLLLPFNARRVPGVRAFTIANALAVLSLLAYASAEILPPAVY
VMVSNTSWLVAVSLVYVGVRQFFGLRPQVLRVGAAAAVGIVAMALMLYVTHDLVGRMMLF
SGYTGVMMAAAGAVVFRQRSGIRTPGVILYVLLSLSALVVLHALRAGVYGSGWAQATSLL
EPAPWGLFFIVCGSVTVPALFLALLLLIQTSLSEQMQAALTFDSLTGAYSRRSILDELEH
ELQRCARSGGRLSVLVLDIDHFKSINDRHGHAAGDAALRHFAQVVPKAVRASDRFGRLGG
EEFVLLMYGCDAAHALVQAQRVCDALRDSPLYLQGQELRMTTSGGVATLQPGDSADGILA
RADLALYKAKELGRDRVEMAWSARASGRPQAAPEEEAAAEAAEPAKLTA
>A0A8F7U714|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MNKLSVKIFIILLPLAISLLIFSYVYYKAREKLTVDHIYQSIQLSVSLGANEISHYVQGQ
FTEFDRLSSEINACEDGNIPLSLSAADALSFTSGFSALAISDLSGRVTHFSLSSNSSNRY
VLRKNTQGLILLPEHVLALLHTSYQEWKKTYPENLRREKDTLNQLLELNKRGEVNSQASR
ELTNLLVNIREGRSLPRQVISLANAETISKLGLIFDTESYLYSRPLIGCDKKIVGFYTAI
LDRTIVEDHLYQIKSTLMQSNLQHVDVLMIRNQGLRSLSAANHLSLDALSSKGLNTTNKP
QMREDLNGILINQPIELDIQSHFISLDNTHPSIPDHQKGINLVVYVSMDELESNNLMLMR
EVFLYLCIALFLFVSLTLYLSHYIASPIIDLRQRISILSKTGKAKTDFSVRDDEIGQLFS
AFSDMAYSIKAKESQLVKLVREDPLTGILNRRALVNHAQDIQRLNSVSCICMMDLDHFKQ
INDNYGHAIGDSVLKTFCTLVTSEIRDSDIFGRLGGEEFALILPETQLEEAVSLAEKIRS
RVEAQLVASLSSIDGSKITVSIGVVEWLDDDFAKALSRADKHLYIAKESGRNQVSAQSSK
SPL
>A0A619AI17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAER
>A0A1S9JB25|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFQLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFTVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWELPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNISALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A1V5M7Y5|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MSENRQRRLSEKEERERLFQRRLAELRARNNQFPWELSENADFELPAEQTKLFADRSIED
PNLTDEEVERRALLDLNSYNFWSFYKRLNYEVRRARRYNRPLSLLFVTIDRLDRVVENHG
LQGENAVVLACGKVLLSCIRDVDVAGRCRDDSFGVILPETPRSGAEIAAERIRTRMEDLG
VDLGHTAIFCTVTVGGSSLDSGETAEQLIALTVKGLKAGIAAGGNTVNFLIES
>A0A518A0H0|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MNSPQIATSQTVPQQQQSVHGSYNMGSSQILRELIAFSAESDELALEARQADEIDQVICR
KHLRKLLTALQARDAATLSHCRRVAFLAKGIATNLGWEGIHLKRLEVAALLHDIGKIGVP
DHIIFKPGKLTSDEIELMSHYHHIGLDVLQACRTDHEVLTILSQTRFHFSGATNGYQCIG
SDVHQGARILAIADAYDSLATDQVYRAGKKHEEIMSILMGAAGTQFDGNIICALSRWEQT
ERDTFHEAIQEVNQNFQPKPLTEQEISEANLISNIFSYLFQIESLYDGFYIVNADFQFVL
FSPGLEQLTEIRAFDILETAWTNHSLPITNQEGTSLASSEHTMNRVIASGKSMTTELMLK
RPDGRLIQIEVQSVPMFGEDGRLVGVAEIFRDLSRSLKRPQEFNELKMAASQDALTSVAN
RGELETQLAILLNQASQNQNASPLSIIFIDADHFKNINDTYGHAVGDEVLIELARLFQHE
TYSGELVGRYGGEEFVILCPETDLDHARLKAERLRLAVNNLKLDNLNNNRITASFGVAQL
EPGDSLESLFHRADNALYQAKETGRNRVCSLTCDEQMSGAAPDIVETAQPNVGKMVFESS
FSALISSDIVVYKLGGFVNDNDARLTEVNPNRAVMRLGKAGLLPFWGKTDDRRPIEVELV
FDNATKKSTSASRNATPRVEVMIRMTPLGWIKQPDVFQQRAARVFRLLKDYFVAD
>A0A1S9IYE5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLF
MLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQ
LSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVD
YCPDNHTATWGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTL
DEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVE
SLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGE
VFGLLFTELNSAQAKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLV
MTEADKALREAKSEGGNKVIIHHI
>A0A1S9JN43|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMRYPGALLARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGIC
AWRSGQDTEQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGP
RLYQKPAVTREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLL
RYWPEENLAIQVTVESLICPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPV
IRLVNALGGRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENLLLVQSLVEA
CSGTST
>A0A2P9H3H2|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MALVAYHVYTSRPTAQAFSSLLFLAILAAAFYRLALAESRRDKTEQALRRSQALLNQAQA
VGKFGGWEYDVATGQVFWTEEVYRILEVGPEYDPSNVAKDIEFCAPDVRTVITRAFERAV
ALGEPYDLEARFTGAKGTHKWVRTSARAEIVGGKVRRVIGDIQDITDRKVAEVRSGFLAN
HDRLTELPNRELFYDRLSQAISRAARRKECVAVFLLDLDDFKPINDNYGHAAGDVALIMV
ARRLKACLRNMDTVARLGGDEFAVVLGDVENPADSKTIAEKIIKSLSEPLKLIDTGECHI
GVSIGIAIFPENGSEIDKLMSAADSAMYESKARGKNTYTFSSEGTHAEAAARPWIALDAS
LMVGSPEIDQQHQRIANLLNNLNTAVKYADEPAELTARLFDEMVHYVRFHFQTEERLMDR
QGYPDRIAHINAHQKLLDEVMYLRTKFIQGGELVVLQSLKDWLLLHIASSDRPLAEYLAN
PQEKALAAPTPEFSIADR
>A0A518FZC9|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGAYMNWPLGIAPLLLLAPATVLAAVSSPRVCYW
TITVISISSCFAEIFFRPDLEEVRSTYPLSIMSAAVLIGLVMLIDLYMGKLRRKLSQLHQ
QNDELVRQLYETQKQSIADASKSAIAELKEKQTSESKDNTSAESGVNYPLLLLTLQDIGR
RISTNQSNESLIPTIISTAKASLQCESCQIYLWDTKSRALKNALPARARDQLDYRPAANH
GVAAWVIEHRQIVMRNDADQDYRLKRIIEEDAQMPDAIAPLTVGSELIGLLIIDKIDVES
PTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLYNHATFQEKLHELVKNAEAQS
TNLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPENSVLARYGGEEFIGVLLD
HEYSQARQIAEDLRETLENCPILFEGQQLQVTASFGVTEYRHPATNTKDLVRVADEYLYK
AKEGGRNQVVGLDSNTTRKPGTQAS
>A0A8B2UQF8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. 9-2|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGATSFIYPLINVIEAVIGALLLRKLLPWYNPLQN
LNDWIRLAIGSALVPPLVGGVLVYFLAPTPEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPKLLLETLTTMAVTLVLSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPVALTTQHTNAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNRRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHETML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LRVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGYFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
ASRLIDTINGYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGIV
TVYEPQQERDHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQVASKGMGVALPLSEVGLASMTLV
DELLDLLDKSPLPGRLLHLIIPADVVCNPDENLQRGLQKLRQAGCRVIFSQVGRDMNVFT
HLSANMADYLMLDAEVVTNVYGNLMDEMMVTIIQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGLDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A7Z7HFQ8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A447RNS5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLISKWLFPEP
TVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSLHRGIVAA
LQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAKKRAAVAQ
FVTRSVDRPG
>A0A3D1BZZ7|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MIQSTRISMGLFFKYCLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A486ME69|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLIIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A0R3JYZ0|diguanylate cyclase|EC 2.7.7.65|Caloramator mitchellensis|TrEMBL
MNKRHAVFRLATLLASLYILSMAFNESFLYHQSTALMIITLFVATIIMGLKQIAADRNKV
ELTDAVFAFVFFIWGWQYAVIFTFVYWIVIDLLRARQGYELIDINKALFHASIFSIASYL
ASNACLYFILNFKVGYLLRYYIMSGIFVGLYLLVNIAFVKIDYYFIDGEKFNFSTEIKKY
LWINFIVSALISSILWLIYFVSGYTGTILVLFILVIIHYFMNVYSELIRKTELMNSLIKI
TRDIVIYGDFSDKINRLVDNLKNLIPYDICAIYFFQSQDEETQLPIAYRAPSELDISELE
FNLSSSAVTAKTVREGKIYISKDVAKDSRIKITGKLSNYAKSIVFVPIIIDNSVNGLIAV
AGGTKFSQFLSQGVIDCLSILSNQLALAFENNLIYKDIKFRAEVDALTGLYNRNMFDNQI
NQLTSSNVPFSFILFDLDDFKQINDIHGHIVGDKALKLASDIILKSIRKTDMAFRYGGEE
IAIILKELSEEDALIIAERIRKKIEKAEIKDLNNYIRITISGGVVSFPGKFKSIEDLIRR
ADAILYSECKNKGKNRVCASINM
>A0A377XRG3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGGNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A422Z4Y5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVNDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A486SS42|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYYQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A377ZYT2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKSAVCGKK
>M1WQE1|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MKIRSFLQITFVTILILIMDIVVQQTALYRYRNQQVVEITQELSPVRFGLEKEIVSGLLL
IQGMANHISIHPTFTQKEFALYAENALRISPVLKNIGAAPDFIMAYMYPRAGNEKMLGVN
YRSLPKQWPQVQLAWLSGGIIVAGPLDLVQGGSGLIGRTPVFVRQNDKENVEGEDSFWGI
VSAVIDMDRLFESVNINALSGLKIAIRGIDGKGAEGEVFWGRESLFDPTGDPVLVDVFFP
SGSWQIAALPVGGWPEESPYSLSIHLFMGGLLLIGLFLSYKDIRHRIEIQNVKEKLGEAQ
AFAHLGSWEQDLRRKTLWWSDEVYNIFGVSKDEFVPSEQGFLQKVHPNDLVRVKEAYRQS
AKGENAFSLKYRILRPDGGVRFVQGQGKHLRNEKGEPTRFLGTIHDITEQREIVNALESE
QAKLQAMAEATYDPYIMIDSQDTILFWSPAAEKVFGWTNEEALGQKMHELITPPEYIEPA
LEGLHHFAQSGKGPVLDSISELPAIRKNGEYFPVERSVSAFQVGDSYYAVGVLRDITERK
KAEEKLAQLASTDELTGLFNRRTFIEMTEYELKHSKRSGSPISLVMLDADKFKNINDTYG
HAFGDEVLQVLASTVLSCVREVDILGRVGGEEFLLMLPDTPLEGAVGAAERIRAAIEQVE
LQHESGETIRFTVSMGISVCNHGEESFDDLFNRADMAMYQAKQKGRNRVETA
>A0A4Y7RCA8|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum propionicicum|TrEMBL
MVVTALDYRHIFDTSPLSVFIHQDGTLQTANPRMVSLIGYSEEELRGKFFEQIYPEDRTI
VADSARRRLAGEDMPDSYEFRAFNSDGELLYLKGFFSLIEYNGRTAILGQLLDITGHKLA
EELLERERSSFSTIIENLPCGVFFLDRNWNIIHQNTASINMLGYTLEEIHTFNDSQLKFY
PDPAYRKKVIEDWLENIKNPVMSRTFTVTCKDGSAKEIEFWPTFLEDGRIVLAMFDVTER
RKAEEQIRTSEEKYRELADSLPEVVYEMDEKGIIKYGNNNCYEFFGCTKDDFDKGIKALD
YLVPEDRVRATQNILRLMNGEKLGIIEYTVRRKDGSTFPVIIHSSPVIKDGKPAGLRGVI
MDISERKQMEERLKTLSLRDSLTGLYNRSYFENEIERLESGGFNKVSVIICDVDGLKIIN
DSFGHGSGDALLIAAADVLRSSLRDSDIIARIGGDEFAVILPNCGHTAAQRAFNRILKAV
ENYNAANPALPLSLSAGFATTNDPLGLGDLYREADNNMYREKLHQSKSTRSAVVQTLVKA
MEARDYNTEGHAERLLVLVSSLGKAEGFPKQRLDDLSLLAKFHDIGKVGIPDSILFKPGD
LTHLELIEMQRHCEIGHRIAQSAPELALIADWILKHHEWWNGEGYPLGLKGEEIPLECRI
LSIADAYDAMTSDRPYRKALSQPEAVAELNRCAGTQFDPKLVQKFIKILNMG
>A0A862ZIR4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYCITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>D8G4Q3|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MKMHASQIHPLPERKRVMTEFMKSIKKGVAWLPNTLVLQKEGQTVWVDINSRVVEWGGSG
KVVQTIFRDITYRVQLENTLKQQAERERLVRGIAQNIRESLNLEEILNTTVNKVREFLQT
ERVIIHRFKTGESGQIVAESIADGWGSSLDWAIGHPWITENQLSNSPQLRQICAIEDIYT
SGLEQSHIELLETFEIRAMLVMPILTGEYPSLLWGLLIAHQCSGVRKWEQLEINLLQELA
MQLALGIQQSQLYQQLKEANVELHQLATVDCLTQIANRRRFDEYLHQEWWRLSHEQKPLS
LILCDIDFFKLYNDACGHQAGDRCLKQVAAAIRAVLKHSADLVARYGGEEFAIILPNTDA
ITALSIAETIRSTIKDMRIVHRGLAPDRYITLSLGTTTVVPGPKISPERLISAADRALYS
AKEQGRDRVGTIEC
>W6KMQ4|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MPAKGTNAFLVLGFGAILICMVGSIIIGFRHLDATREAWLRDAAFREKVRAAFLMREAIR
ERSFRLTYAATLSDFFDRDEQHELFNAEAAHFLVALDMLQKLKVTPTEEKALASLRETII
RDRPAVEKSMAAIVENGYGEGIQATLEQGLNAQRELITELNRFVKTFEEISLKEAGGASA
AIAHTQRNMMFLSGGALALALTIGIMVSAREGRNKRRLRDNRDQLAKMSSTDALTGIANR
RRFDEFFEFAWHQATRSSLPLSLILIDIDHFKLYNDHYGHAQGDDCLVAVARAIDDVIGR
STDLAARFGGEEFACVLCDTSVEGAIALAEQVRLAVAALGEEHVKSQTADHVTVSVGLAT
CIPSRDGDMAQFFKAADSFLYAAKHQGRNRVIFGSCEIEDAVA
>D7Y8M4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain MS 115-1)|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
VKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTILKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRQVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A3M2RJ81|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MPQLAEKFLPSKLSKIGFIVLALTAAGFAALREPLAAAAAASTAGLFLTGMHGNRRRQSM
PWRQLRILFFITLNLALFTALWRGPWALSHWLYALPLITFGFVPAYLATVVTIVGVIFVI
SSTQWLITLPDRHQMISAFVLSTLLGAILIFLQKYKDRQLKPLRRTDQLTQAASREYLSA
DLHKEIQRSEREGTHLSAMAIGLDTHLSDTAPDADISAILPRIGRYLHSQLRDFDTYYRM
ADLQFLAILPGTNTAEAADTAERIRIGLCTLMASHGLKLTVSVGVAGLNIGDDADSLQIS
ASNALRRAQQQGGNRTQTYSNPVPHELSGTKGAAQ
>Q32GI8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLASLNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCEVYWQ
>A0A1Y5SDU8|diguanylate cyclase|EC 2.7.7.65|Aquimixticola soesokkakensis|TrEMBL
MTRQPLTMTNSVLDTLMPMHLLVSACGTIRRAGPTMSKLREGPLAGQAFSTLFTVRRSRR
DPTGEESFIPLNQKLHLVFCDPPKTSLKGIAVPVLGSSDILINLSFGLSVVDAVTDYELN
SADFAATEMAIEMLYLVEAKSAVLEETKQLNARLQGAKIAAEEQAYTDTLTGLKNRRAMD
HVMERMTSSKVRFGLMHIDLDYFKSVNDTYGHAAGDAVLQTVGRILSEETRGDDMAARVG
GDEFVLIFNRFTEVSRLVKTAERIIERLEVPTIWEDAQCRISGSIGITTSDFYDTPDVAR
MLADADAALYLSKDKGRACVSVHDPAVGQEAKGAPLGPPADRAGQQAGRLG
>A0A140NCD2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain B / BL21-DE3)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4U9I0J7|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MFNWQHLDHFNGVLLRIPHPPGKGRKAILGSITIALTLLWLLFTGMLVVSWFVIRRMVSN
MYRLQSSLQWQAWHDPLTRINNRGALFERAKVLAKRCEQQQQPYSVMQMDLDHFKNINDR
YGHQAGDKVLTHAARLITSTIRKVDVAGRVGGENFVSSCRGRP
>A0A1C6FSS5|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MDRVRSLERENARLLQLAQHDYLTGLYNRGATQEKVEQLLRQTGDGALLVLDVDGFKQVN
DQYGHLAGDRLLQQIGQVLGLLFLVEEPVVGRIGGDEFVLYFPGKKGPDFVPSAVRRVRD
RLAAVPIQPDSGVYLSVSVAGSAAQPGDDYLTLFDRADQQLLRRKRRRSPPSGPLVPVQG
LDADIHKVRQDLREQKRLPGAYCQDYQTFQSIYRFVERGLQRTHRHCCILLITLTDGQGD
LAPLPRRQREMDLLQETVSLSLRAGDVFTRYSSCQFLIMAIGASSEDAGHIAARIQKEFY
QKVPASSDTKLQHAVCSLVDIGEPARS
>A0A087B943|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium catenulatum subsp. kashiwanohense JCM 15439 = DSM 21854|TrEMBL
MIPVRAMFHICMELWGIFICLIFAGGIFIATPQKTRRTRIKILMQIACMLLLGSDALSWY
FHANADETTYYIVRISNFSVFCINYIFMSFFATYVWLTVSKNQHRKPAALHTVYALSVIG
ILLLIITQFTGLFYYFDDHNLYHRGNFYLLSQAIAVSGIALCFFMLISYRKNLDRITFLS
MMSFFVLPVLATIYQALTYGFSLQCLAIVISTQIMFIMDTVELNMRFYSQQAAYEKARYK
AEHDGMTGLLNKEAGYKRMRKYFDLMDSYDEAMLMFVDIDNFKTINDTYGHTVGDFWIRE
VASQLRHIYWQDDIICRYGGDEFIALIRNTASEQVLETTLGMFFQQLTRASEQHGQDVHC
SVGVCRIAAIRISGNTDISRNTDGGNGEDTRGGVDFGQCVKQADLALYETKRSNKGTFTV
YNYDRS
>A0A5B7XPH7|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNRKFKEIDETVRGLNQSTDAHFKWLVKLLRFIDSGDVDIPEICSDDAHLHCEFGHWLNT
RLLEEREDTNFLLDINKKHICVHQTCRSLITAIEHRRQKSEDFDLFEQSLLAFTDALTTY
KVHLLQLRTSYDALTGLPLRRILDESFCSMNKELGAEGLYLLLLDIDHFKKVNDNYGHLN
GDIVLRSLAMNISNNIRRSESMYRYGGEEFIVVLHATNDREAVTIAERLRRDISRLETIA
GEHIIRITFTGGLTRIHQEETLREVLERADIALYTGKKSGRNCTHLINRDLQTQKYCD
>A0A011NQA1|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MRRRVPLSQSLGELLLGTDPAMRLRLGQTGLALLLMLMGMAVVLWAAWTLDLPRAPLVLW
TLTSLFAIVMVYMTIRCGWSLRFKDPSLTLPQMAIAIACSASGYALMGPVRAIAFPNLLI
ILMFGMFGLRAGSALGISIYALLAFGLSMAVMSSIKPDEYPATVELAHFMMLVIVVPAVS
VLSERLSRIRRRLGEQKRELTLALEQIQLMAAHDDLTGLLNRRHMQVLLEQEAQRSLRSG
EGFCLALLDMDHFKRVNDRHGHAAGDVVLRAFSDTAQTVLRRSDVLARWGGEEFVLMQAD
INISRASATLVRLREQVSKLKLTFGEVRLQLSFSAGLTAHRPGESVTQTLERADRLLYEA
KAEGRDRVVAG
>A0A1C3JUN9|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MHPDSPRQANALLYKAVPLMRKMDIAPTPYNYGIWYEYVRQTSPKLNQLMDSTIGRLGSL
PSFISKELFHQFLVAEEARYNSDHKDRLEELVNSVSTSTYTMTESLQELGSVIEKSRRVL
SRADRQQHLEKVVRYLDQGTKKALEEAEYFSTSLHKVNEEVLQLKAELDEMKNNVDLDPL
TQLLNQKGLERQLYSLIPSSEDDLSLLILDIDYLKEINHKNGRRAGTALICHISRILHSK
KLENATIARLNGGTFAIVLHEATLDYAIEYAEILRTHLNKQRLKNRSGEGIIDKICVSVG
VATVIGQETPANLIARASGYLDNAKRQGRNRTASR
>A0A8G2A5B9|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MSDFILARVSQTLANEHSLEMLVRQLLEMLELVTRMESTYLTRIDLKAQRQLVLYAHNSS
EMQIPEGFSVPWNESLCKRAIDDNCQFSNDVNTRWPSCIAAQGMGIITFFSIPVRLADGS
LYGTLCATSRNKQPYNLEGEQVMELFANLISHYIEKETLVDQLRTANVALEMHSYTDELT
GLANRRALFKHLSSMFPRERERQRNLLMIFIDLDDFKAINDRFGHQCGDSFLIQIGERLK
ANIRQGDLVGRLGGDEFLVVGTELDTVQQQSFVATLREALRGVYFLGEHRINYPGASFGV
TEVNPQIQDVESALRAADDAMYQDKKSRRRDSFLNID
>A0A8G2E7R0|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MHTNTLSTRFRYINTLIVILTTAIFIGFIIREYRDLERYMSYVAENGKSALSHAEYINQN
MAFQLSRAFSAAPSASDEQRIQRDDICAHLESVNGVLGLNLTRQTFHGLNGTLQTRNPDC
RSWVRDVPSLSVIQNDRHLPASKYTFSSYRGYIFNNLRYYIDLDNDYIYINKPIAANQYK
FDNWQVRNDNAIDITRSAHIISIDRRALNDFLHGENVTSHVYRDGYTKKNIISMLTPVFK
NGQIKGIIVTDVNIDDLATAFYTADRPILWRFLSLYLTDEVTASDIYFNRSTIKSINIIQ
YQEHLTPIYLLNIKLDLIYFIIDNLWLAFIYVMSTWLLCRYTKKQMTRHAELSKDNITDT
LTGLYNRKILNEALSNKIDAMLKKNIPVTLVSIDSDGLKRINDTLGHDMGDKVIQSLGQA
IEQSLRKSDYGIRPGGDEFLLILIDTDYAKSLEIIARIKENLRHTDKDPRVSFSHGNYPL
KPGDSLESAIKKSDKLLYVHKRNKYGEAAQ
>A0A1V5GF08|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MSEKCRLIGVCISKIQDEGRFWMIKALNEYACKSNFRLLIFNSSSTLAEQGNKSDSGESA
VFRLIPYDKLSAMILFSEFIKDEALIRKIADECISRRIPVISMEKKLDGCVCFSFDHSNV
FEKLCDHIIQDHGAKKLFMMAGMRNNSFSDERVAVFRKALENNGIPYDNSLVGYGEFWEG
PTIDTLAQWFEKEKRDIPDAIICANDTMAIVVSTYLQKKGYHVPEDCIITGFDGILHTEC
YVPHITTCKQNNNKLARLSIETIEKMLSGEPYETDNVVDFCIVRSQSCGCMPIAPENQNE
SVQMIMDRLWHTMQNHEMMCDIQSAIANISSLPELPSILIEKFVFNTLVFAVNNDLFTAP
GFGKHHHEEASFSSNINVLYHQYNWNLCEPCTISLEQLIPEMDMMLESERPIIFCSIHLL
ELVLGYCVFQPDITFDDYEKINMYMGTVNSSFGTMHSKAQIEYANKELKNLYIHDHMTGL
LNRRGFYRLLQKLIDSSENDSTSIVIISADLDGLKYINDTFGHFEGDNAISEAARALLAN
TSDMDICARFGGDEFVVAALVPEGTEKQYFIKFKNGFLKKLAEYNSSSGKAYQIGSSIGF
FAEKLTADFDMEKMIQLADKQMYADKAARKKERNN
>A0A2Z3XBU4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. CRE-46|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKAEYSPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A0T7EQR9|diguanylate cyclase|EC 2.7.7.65|Vibrio coralliirubri|TrEMBL
MNILKFIIKQRHWMIACAALSILCLHIGDIRKLIGFVEKDQQHRTQLIQFLVQDNISRTL
EILRTTLSPSLGHVDINSLEGVLHSSSSPFSGSDVQIVARRFGLNPESSTFTNAIKHKHT
LWGLDYDQANSQVHLIAGSIKPPNYFETHFDLMPYFPKINSGWNTIIMIENEKKEVFMPS
GEPAKITFTNNLIRSGQVNADSTLHFTETHLGNLLFFRLGSDDNRYFHLITVPLPQLNAN
LLVFDNMTSSVVEIIVSLQNLIEIILLLGLFYVLMQAFSRYQDRTAQALQSDTLTGLKNR
LYLETASSRIEQTQQHEQARCVGVIAIDLDHFKMINDKYGHHIGDCVLVRVSEILLESVR
RHDECYRIGGDEFIVIIKTEKQSDIVKLADRIRAKISSDQQLHNQVNGGISASLGLVDLS
TGQSIEEAIISADELLYQAKHRGRNLVQSSI
>A0A0T7DBG0|diguanylate cyclase|EC 2.7.7.65|Vibrio coralliirubri|TrEMBL
MSLKKGHFAVHFIFPSRLLVLLFLVVSSTHASEFSKKNLLLIYSYNPTFETTGKIFEGLR
SGLGNLDVNIDVEFMDSKSVNNDITQKNFHTSLKYKLSTKRIYDAVVLADDNALLFGLKH
QQELFLNIPMFFLGVNDIDVAIDQNQNPFVTGVVEAVSIDENIEAVIKMLPNHTGIAVVS
DGTTSGKADMSQWNRLKSDYPDISWITLSLDHLTWQEYKTELNSLNPNTNVLLLLSAYRD
AEQVSKTFKESLYFSAENTEVPIVHPYVHGLGDGVLGGVVISHKKQAYEVGLMVAKHFSG
VEVHDIPVLENSPNIPMFDERQLSKHNISPSSLPNNAIVLFQEKRILDTYSLEINFILLT
LTVVLLAYSFIKSSKAKLSKDNERKLQTILDSIDIYIYLKDTNGRYLFANRVVRDRFGLT
LNQVKGKKDSDLYDVHKAKSVREVDELVLKSKEKYSQDEVVWSEDLQQHQTFRTTKVPLL
NDNLTSYAICCVSFDITEQKRQERMLEQTAYYDVLTGVANRILFMDRLKLAIGRSRESGN
TLFVALFDIDDFKSINEQYGHDFGDAILKKLASRIQKIIEKEDVLARLGGDEFHFMFESK
LNGHAEVELVQSCVSRPFNIDGIQVDITASTGVTQCSTNSEPEHLIRQAEQALYIAKSNG
KNQVQYFSSNELRQYEPQRLKSLLSAFSSQEFVLYYQPKVSLTTGEVVGVEALIRWNHPI
EGLLSPAEFLDDIEKYDLIKALDDWVFDEAIRQANQWFKKGIKLPVSINASHEYFRQKNI
ADILKSKLELYPEFPSSLIEIEIVESNALENLVDVANTIRSCSELDILFSLDDFGTGYSS
LTYLQQLPVSTLKVDRSFVIDMLTNVTDRRILEGILGFCRAFNLTAVAEGVESLEHGRVL
KSIGYDVAQGYGIAKPMNQNQFLDWLGVWVPPLEWNLSPDQVAEKTRMIASKNIFPIGKN
ETNIL
>A0A8E5MWK0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Dessau|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2H6FY11|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MAKKQIMIVEDESIVAEDIKMSLQGMGYKVPAVVSRGEEAIKKATKFRPDLVLMDIVLQG
EMNGIDVAGQIRAKLNIPVIYLTAYADDDTLSRAKVTEPFGYLIKPFEDRELYSVIETAL
YKHGMEKKVKESQEWLSTVLKSIGDAMIATDMDGRIMFINPVAEKLTGWKQEEAKGKTIE
EVFNIINEETGERAESPVKKVLRERTVVGLTDQTILIARDGAKRPIDDSGAPIRDEKGNI
TGVVLVFRDITEHKKLQEMIINAKKEWEETFDIINEAITVHDSDFNIIRANKAAETMLGK
SFKTLLSQKCYLSYHGTTCPPEGCPSCQTLKTGIPSTTELFEPNLNKYIEIKALPRFDKD
NNIIGVVHIVRDFTKRHKLEEELRSLSLTDELTGLYNRRGFLTLSSQQLKIANRLNKGVL
MLYADLDGMKWINDKFGHKEGDRALIETANILKQVFRESDIIARIGGDEFVVFPIELTDK
NARMLNDRFMRQLETYNAGRQDRGYKLVISVGIVHHKGRCPYTIDELLIQADRLMYEQKI
NKKMA
>A0A080LWM8|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MAMKMPAHIFDRRSLLILLSSVLSIGFFATTMFGYFVSKQAIRAAIISEDLPLTSSNIYS
EIQKDLVRPVLISSNMAHDTFVRDWVIAGEREVSAMARYLKEVRERNGAFSSFFVSQQSQ
LYYTGLGVLKQVNRKEPRDAWYFRVSEMKEDYEINVDPDLANKDALTIFINYRVFDYAGR
YIGATGIGLTVDAVRHLIALYQERFHRTVYFVDQQGRIVLFADQTGLHPDLRTNPGVGPL
VDRILEEKKGSYQFTVAGDNHILNVNYLPELKWSLFVEQNEEVALAKIRHTLYVNLAISM
VVTLIAIYLTYLALGRYQSRIEEMASSDELTGLLNRYAYSILQERMLASWRRTPKPISVL
LIDIDHFKSVNDRYGHLFGDRILAAVARLLREVSRNSDIAVRWGGEEFLLDQISLRTDRT
SGASSGTGAAAPTVRHRTRGTRPVDVRLSSGLVSDSAGDQRQATPPCRVSPFDHLTITEE
TTARAVIRQQCRPYDSFGALFGAAGSVLATHPGTAPARADRIDLDRSAFQLLGSEASQRV
ECRFRHPVARPEAAHLGQLPHAGRDVDDPPPAIFAHQGYKHLNQSQRRERVASVRRRHQF
RIDHENAGRLRNHEIRCFEKNAGIVHQNVGAAKLAAQAGAKGGNGAGIGNVGDVRQNLVP
TLAQLSGGIFDRFGAAPDHQYHAPGGGKVARHGEADATRGTGHDGKFLS
>A0A8G0FU94|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNLNNLSLRWLTTLNALAVVAGFLMFYLTFKYFWSHDREIAQVLQLQLAELQRVETLVSL
ERKAMGASLADYAAWDEMADFIAEPNLEFTERNIGEHAFSSQFLDGVFIYDSDGNLVWGK
KYDATIGQSINYEHLLPDFSRILQQAASLNVNKISTSVRYMVVENEPYLVATTRVCNSEG
KICDKGYLIFIKKVRAQFANVVEQATGVDIEVLTCKNDAPLPKDEVDVSYIKQLDYSGNS
SVLFKINHHIKHPPFIRTEEILALLFFSLVMYLVNLWVVIALIKPITTASQVLQQFKTSG
GKMPDASTFISSEMKEFATTINRIVGQLEESQQVLRWQSEHDPLTRISNRRYLEQQFKSY
LSDRPQAYLVLFLVDIDFFKRFNDSFGHLAGDEALCSVADVLQSVEFHGEKIVARFGGEE
FCVVLASDCAFDAEQYAQQMRSKIEQLAIANPVDALCQYLTVSIGGVYAISPKMESYLAL
FHQADMALYHAKEHGRDRYVVRNFV
>A0A1V5TYE3|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin248|TrEMBL
MLSFLYVELNCFAIAVLLAIYLNIRRYINKYLLDQKIYLTLIYVNALILALDAAMWLLDG
LPGLVTHIAFSMFTTAYYILNPFICVMWYLYADFYIFRSYARLNRRMLPVMIPALVNLAL
SVASNITGTLFSIDAQNVYRRGPYFLILVSISFGYLIYSMLFTLAHRRKIQAKDFLMLLL
LPLLPLAGAVVQVLHFGLSLIWILSTLSTLIIFINFQNVELDTDHLTGLYNRRQLDSYLH
AKSQSAGTKAVAGVMIDINNFKRINDGYGHDEGDRALAHVADILKRTFRENDFVARFGGD
EFVAILEMNDKSGLEPALARLKANLAQFNEKKLAPYEISLSVGYDFYPAEGAEPSEFIKN
IDRLMYEQKKKLREAEAKQLTIEN
>A0A8G0CGM5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSKNLAQAAASLLQLEHLGISQYDLSQLLCQHLSTILPIEGIQFCHPTEMAMCVHHEGAC
LNEHDFDRTWWQWLSTLRRDAGFVAIPNHFLVSKQFALACRLSFEEEHSKVLILLLGSSE
HFQTHSDEWHMLASVLQQFWLTQSIKLLAAEKRRAVDHQYGLILNKLQTQTRRHQAMSKV
ALGVAALTATRTEFDLLKESVKLLREELGIDRVGTFLIEHKASRYHGIFGTDDQGCYRDE
SNDYYPYTQLDPRFLSVLSNPYTWFHLVTDITLYHLQQPIGHGWNAMVVLRNESLEPLGW
IAMDNLLTQKPFDNDIQEALEVFAKTVSRILVEIRHNNRVRMISQALQLMSQARNSLEIC
RQAVEISVSQLDIDRIGIFLPCDTDPNLLLGTYGVDTDGVIREESYFSMPYPKTPLFDEA
YANPNTLVLLNDVPLWHDRKIVGHGWNAAIALSVDNQLIALICADNLLRQRLLSEHQHEL
IQLFTRNFGEMLARLRGQEKLEKLNKTLEERITERTKELQSLNQRLVQAARTDSLTQLYN
RRAYEEFIQECWQTHQGQLPITLAVMDLDGFKSVNDQLGHQVGDEVLRLFSNLLRENFHH
PTAYIARLGGDEFAVIMSGHESQSHLTMLNQIITEFEFKTAQRFQGLSVSIGAAIVIPNA
EMNTDSFFSLADQALYQAKASGKRQLVVYPLAQNDPAWMTNL
>A0A8G0CD85|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MGVLELDIQAELQKLKSQLEQVRLTQRDTSFKFNREQQVLKRMVTSLATTSRGSSPQLNQ
SLEELCFALEQQKDISTLIPKLAVLERMLKQQSLVMDKQTSHLDSQLQHSGETLLRVPGL
PAKIKRDLRDLLSFSAAQPLEKTQQALRLLEIYERAIKIQCANPNLALNELSQQADRELL
HRLAIDLQHLITELDFNGESGDQLTDIRTKILLGVNTHTLLELTLEVLRLVVDGSHAERK
AAEVFLEQVNLSIGNNLKSATQNLEQSQSYMAHRQEMNGELSSLVARSQAAVKEQTELEQ
LKLKMAPLLREMSSLSERLLLAEQREQALLERMRYSQDQMEALADLAQDYRRRLEDQALR
AQLDPLTKVYNRSSFTERLEHEYRRWIRTQHNLRVVLFDIDKFKSINDSFGYAAGDKALS
IIARTIKKELRDSDTVARFSGEEFILLLPERSDNESYQIIHQIQLNVSKLPFKFRDKSLT
ITLSAASIRFMDSDTPETVLDRLNLTLSEAKHIGPSQLVWK
>A0A656A635|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNQRMSLTWIICAPLFIVFVLAASVFQQYLYDLNQEIDDAYADIQQQLERAEKVVTALDY
TFTHNQRPAENILFKHSARVVANVCQIKPIDGLVLAQGLSSSFAVPKLDLSYMLIGDASL
CDSKPSHDPSLQIKLSMAPILSFLHDMDEYIYGVHYVDSSGYIISSPDTISEKVTYQQIK
DFISESPLWSHAIAAPNMIAVDGPYRSVIREQHEWLLTLILPVYRDADYQGLVAVDIGLR
ELLSRMPHLASRFDMIDLNEMAIPTFAYRPHKLTSEYADYHQVVFYKLDIQSELSNFLTE
KSGNLLVVALVYLFLTGVLIYLNTRWDRQHYAQLAARDPMTGLLNRRGMESFLKGKRHSQ
YLAIAVLDIDDFKQINDAYGHDMGDRVICYIGEQIENHIRSSDAVARFGGEEFVVYVTAK
EKEQITRIMQRIFDAVCRESPLILEPGFTISGGIXXXXXXXXXXRSQF
>A0A655ZDN1|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTDQTRTSPLVNRLLKMISLCALGYLLIILAIIIPRGIQSVEQQKQELEEKLALSLSNSA
AIALYVNNYDIASEVMDALLLHKEINAVKLASVGGIVFERTTIPSTYKEQNYWSDANRYR
LDSPVDGNLIGYLMIHEDHQVVRQQAINQILDQIAVVLIQFLVTFIALIWIVRRLVGKPL
TDLSQALSEVRPDHDRKVAVAAEDHHNEIGLVAKSINEFIDASHQALLRERELRQQIERW
ESYYRTIAEQDTLTGLKNRLGCEKFVLRKQRASTTMVLLLIDLDGFKQVNDTLGHAAGDE
VLREIAKRFYALAQTHFSDFVVGRLGGDEFAIYIPLDEFVAESIERFAAQLIESSSEPIA
LGQQSAQVGCSIGISHMNSLHIDLEKLLLQADKAMYWVKYRGKHNYHIYRTGEEILPLPS
AKELKQDQFR
>A0A655UKG0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNQRMSLTWIICAPLFIVFVLAASVFQQYLYDLNQEIDDAYADIQQQLERAEKVVTALDY
TFTHNQRPAENILFKHSARVVANVCQIKPIDGLVLAQGLSSSFAVPKLDLSYMLIGDASL
CDSKPSHDPSLQIKLSMAPMLSFLHDMDEYIYGVHYVDTSGYIISSPDTISEKVTYQQIK
DFISESPLWSHAIAAPNMIAVDGPYRSVIREQHEWLLTLILPVYRDADYQGLVAVDIGLR
ELLSRMPHLASRFDMIDLNEMAIPTFAYRPHKLTSEYADYHQVVFYKLDIQSELSNFLTE
KSGNLLVVALVYLFLTGVLIYLNTRWDRQHYAQLAARDPMTGLLNRRGMESFLKGKRHSQ
YLAIAVLDIDDFKQINDAYGHDMGDRVICYIGEQIENHIRSSDAVARFGGEEFVVYVTAK
EKEQITRIMQRIFDAVCRESPLILEXXXXXXXXXXXXXXXXPDRSFEDLFKAADEKLYVA
KTSGKNQLVY
>A0A655ZRY5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIPLPIIISKSSVLGQGEREHLHFNKAFVKELGYTMAQIPNIETWFERAYPQIDYRQEII
AQWQKTVDEARAQGEDVAHMPALIMCADGVQRWFSVSAQIEPSCRDDLHIITFRNIHDYK
ISLAEAERQSQIDPLTQLKNRRGFFTWSEPIAPETLLGLIIFDIDHFKQINDTYGHPAGD
YVLRQIAGLLEQNLPPLSCCVRWGGEEFLVCFECDDMANVIGLAENIRDYVESHTLMWQG
QQIALTLSAGCTMGAMMSHNWDNLLHTADQALLSAKRLGRNRVIADR
>A0A655R316|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLNELGVYVFVKNRRGEYLYANPLTLKLFETNAQSLLGKTDHDFFHDDQLSDILAADQQV
FETRLSVVHEERAIAKSNGLVRIYRAVKHPILHRVTGEVIGLIGVSTDITDIVELREQLY
QLANTDSLTQLCNRRKLWADFRAAFARAKRLRQPLSCISIDIDNFKLINDQFGHDKGDEV
LCFLAKLFQSVISDHHFCGRVGGEEFIIVLENTHVETAFHLAEQIRQRFAEHPFFEQNEH
IYLCAGVSSLHHGDHDIADIYRRSDQALYKAKRNGRNRCCIYRQSTE
>A0A1V5U201|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin248|TrEMBL
MGKWPGLFWGQGKTYIQLASDNRKAAEEYNENMLSVLTLMGGLLMLLPMLSAPFSNTKTD
AVPVYLLTASIYFALYLLFKLPAMKKHALCGLYIVFSVFFVLAIYLSVIHSPGMRATVLL
GAFCIIPLGFIDRPSRMNLFAVFWLTVHTALAFYLKPKYALDDAINCLCFAILGCFLGNI
MVRVRLESYEARRLLTIEKETDVLTGLFNRRKLFETLAVLETADAEKPSGILMLDIDYFK
EFNDSYGHAAGDRYLNRFGEALTKFAQNFRLHFYRYGGEEFVAMAYGYDEKELFSIAESL
RIAVQSTDMDGHHITASIGVAYCGGEQVLNYEKVIDRADKAAYAAKRAGRNRVCMERNEA
RA
>A0A655UY57|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MAKSINEFIDASHQALLRERELRQQIERWESYYRTIAEQDTLTGLKNRLGCEKFVLRKQR
ASTTMVLLLIDLDGFKQVNDTLGHAAGDEVLREIAKRFYALAQTHFSDFVVGRLGGDEFA
IYIPLDEFVAESIERFAAQLIESSSEPIGLGQQSAQVGCSIGISHMNSLHIDLEKLLLQA
DKAMYWVKYRGKHGYHIYRMGEEILPLPSAKELKQDQFR
>A0A655U178|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSDTLSDTSSFANVIDKSFKDLERVEQDNLSIEEVMTVIRRLVSDSKDIRHSTNFLNNQL
NAATLEISRLKEQLAKVQKDALFDSLSGLYNRRAFDGDMFTLIHAGQQVSLIMLDIDHFK
ALNDNYGHLFGDQIIRAIAKRLQSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVR
RSIEKLTVKDRRSGQSVGSITASFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL
>A0A656AAE9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTMTKSTHSPAFTGSELLNTYYQRRVSLFIGFISSLVFFPLAVKNLLIDYVLLGGLIIVF
QCTLLIEITAIYYQKKTPWGFRLPLALVVVIVVMAIHIFGTLASYWLFPVLIAIAFLLPQ
KDNLLTITIIIPASIWVLIPHQTAEVTLRFSLAISACAAIMYVVVDAIRKLHTELFYLST
RHALTGTLNRHQLDGFLKKCLRHRQLXXXXXXXXXXVIDIDHFKSVNDLYGHDTGDKVIT
QVVEIMNTHCRELDLLFRLGGDEFLLLFENTSLTDATLVMSHIGCRIQQTHYPYHAKVTV
SVGLAEALRTDDPEQWFKRADQALYHSKKMGKNRVSFDEEHVIELNGDHCHALLGSTHGH
R
>A0A8B4CJY7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKYEPVSALRLFNYCLIAA
LLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPLTVMLLDIDYFKSINDNYGHE
CGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFT
WQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A1S9JP00|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MTRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMR
ALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAAL
LPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQS
GSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLR
NIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDIL
YFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRL
QKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDE
FCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLY
VNKQNKNSRS
>A0A0E1CC01|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQIFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A822TPQ5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDHLGPLDNDELPY
VRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNM
DVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATY
LASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTA
GVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7L6JUS1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00524|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7W3A7N8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00901|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRSGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWEATSFTYLSINLIEAFIGAVILRKWLPWYNPLQN
LGDWIRLAIGSALIPPLVGGVLVHFLIPSPEPLRTFLVWVLSESIGSLALVPLGLLFKSH
YLLRHRNPKLLLETLLTMAATLTLSWVAVTWVPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVISLMIARNPLPLATQNASAMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGVEGQWLQANKALCSFLGYSQKELQSLTFQQLTWPEDLNSDL
KLLEQLVRGDINNYSLEKRYYTRNGEVVWALLVVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHEAMV
PEDRAHVEQVIRDSLMDRLPFKLEFRIRVKDGIRHIRSLANRVLDKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPI
LTVLHITFGENGPLMENIHSGDMSRSAIEQDVVLHCRTGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHAINNYHFMWEGRLHRIGASAGITLIDENNNQASEVMSQADIACYASKNNGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLMLIARSVASPRIPESCNFWLISLRLWTNQ
GEVQEEHAFRSSLAEPELLHALDRRIFSEFFRTYAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKGTLPGRLLHLVIAVDVVRNPDERVQQGLQKLRHAGCRVVLSQVGRDMNVFN
HLSANMADYLMLDAEMVTNIHGNLMDEMMVAIIQGHAQRLRMKTLAGPSNQPIMMDTLSG
IGIDFIYGDTIAEPQPLELLLNTSYFAIN
>A0A822W9F0|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MTGALSRVTMLSTLREQQEIIKRQGQSCCLVMVDLDYFKEINDRHGHQMGDRVLATAVRL
FIENLRAYDKVFRYGGEEFLLCLPFTDLDMGFAMSERLRKVLEAITIDDGKEHLIQVTAS
FGLALLEPNKPIEESIEHADKALYLAKSEGRNRVRVWK
>A0A2K8QM56|diguanylate cyclase|EC 2.7.7.65|Dickeya fangzhongdai|TrEMBL
MHTEQRDNSELLLTEWQELVNLTPSGAHQLLSDLCEEELRQLVSVFYDYMLQDKQASIYL
NTQKVADKLSESMYHWLRSVLGSAKGSLSVLLERQQQVGVIHARIGIPTDLVARGARKLK
NELFKLLARKRNLDAALINQAVCFSSLVMDTAIEAMTTAYSPGYKSAMRDQERYRILSIY
DDVNVERERQLGALMNWENQFIYNVATGLPSEEIILLEKSEFGLWFFHKGRHLFNGPDLL
QKLEGLIRQVDSRVRETFPHHVENTAIRTQLLRDIRQLIGQVNAILCSMFDELIRFENGK
DPLTNLLNRRFIPTIMRREIALAISSGKPFILAMIDIDHFKKINDSYGHETGNLTLKTIA
TKIYESVRSSDYVFRYGGEEFMVLLVETQAQQASMIFDSIRQMVAGLSIPAMAEQGVSVT
ISVGIAEFDNHPDYQQLIKKADSALYQAKANGRNRIEIFN
>A0A403QJS9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kidderminster|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7D7XCP9|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MMVRFVLIIFLMTIYCQNAFAATGHHNSIPTLLTDVTYFHEDSTTPLSFAQAEQHFRSGE
NQHPPQDFMSFGINKRATWIKLNVQNHTHVEQYRRLNAAQPWVDSLAIYLVNDQGVIQTW
HSGDEQVADSHLLPGVGFVFDMKLPPGQSQIFIRGQSLDPLTLPIALLDAYQSRTLDAQI
HVTSGILYGILLALVGMNLVLYLSIKQLDALFYSLYISCFIIVNISYNGYGFAWLYSNSL
FIENNLTLIMMVFHGVSGLVFVSHFLRIHQHSPKLNLTLLIYSGLGILTMVTLISLNMHL
WATKFAFKFLSLTTMLMILLGVLNLNKTKDTLYFLIAVMCSMLGLLITTFSVWGVIPYNY
YSYNGAVFGVVFEATILAVIVAYRLKDFEQQRITAEYLSSYDPLMNLFNRRSFMAAGHQC
IQQSNRTKKILSFVMMDIDHFKQINDTYGHHIGDLTLSHIAKLLKRHTRENDIIARWGGE
EMVILLPDTNAEQALAYTEHLRATIAATPFRDEAQDIQITASFGIATRMNGESLETLYQL
ADKRLYQAKQQGRNRVEPQDRHLPITTQEQY
>A0A7D8B2F4|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MKKRFSIKGRLLTPLVFALALVGMLFEGHIRQLERELGEEYERIEREFFRASKMLTILDY
SLNNYIKVRQSLILTHTTKIVNGVCQMRPKFVATDAEERSNAHLQALEYIIVGDKSLCDK
NSKLHHEVGFRIALAPVISLLHDLDDYLVGVHYVDPSGYIISSPDTLSVNATTDVLEQIQ
SPNWDVYQDLGENQPINVRGPMVFQELQSTEDLVSLMLPVYSDHQFEGVISLNIMLDKLL
NTNQRLAGKLHFIDTQRESLPTNAFQPHSLQGEGISFHHAMYYDMRWGNELYQFVSLKRK
TLTLITVMYILAVMSLLFMNTRHAKSYYEGLAVRDPLTGLRNRRGFEAFIEHSPHQSYVA
IAMIDIDNFKAINDHFGHDIGDEVIRYVGDQVHCHIRATDTIARYGGEEFVLYLTAERKS
YLKKTLTRVKDALCGESGTIVKGGFTISGGVEIVACRELNDIDAILKSADEKLYIAKKSG
KNQLIF
>A0A447LJU3|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MADLHLLISNATAGFYYFTLAVLIAIDIAISLACFIAYQCDTRKKHYLMLSLAFFSGVAF
NMGNTICTQVPLAWLDAGSTVTIEQSHKECILNFTRQLCLITIIFIALLINAYKNKINPK
FISGVIVVFSSLALFMMVIYSIESDLDNEILKSIYIYYLSGKKINSGDLIITAWCCLLII
LSVCMFFYKAFKKKIWHCIAAMIFAEMLFNFIIYICTHEPKFSLTVASVFTAIIKFTICF
VVVNEAVKKIAEMRRIKMYDPLTMAYTRNYFFDELKSFSDSHDDNSDLCVLLLDVDKFKE
INDTYGHQQGDTVLKTLSEIVRSRIEPKNIFARLGGDEFAILLPECSLSQACEVAEAIRQ
DVEQISYQTEVGSIDNITVSIGTYKVNGSDSIKQIIASADNALYCAKRNGRNNNVVFKDE
FCAP
>A0A1N6LZI5|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MMVRFVLIIFLMTIYCQNAFAATGHHNSIPTLLTDVTYFHEDSTTPLSFAQAEQHFRSGE
NQHPPQDFMSFGINKRATWIKLNVQNHTHVEQYRRLNAAQPWVDSLAIYLVNDQGVIQTW
HSGDEQVADSHLLPGVGFVFDMKLPPGQSQIFIRGQSLDPLTLPIALLDAYQSRTLDAQI
HVTSGILYGILLALVGMNLVLYLSIKQLDALFYSLYISCFIIVNISYNGYGFAWLYSNSL
FIENNLTLIMMVFHGVSGLVFVSHFLRIHQHSPKLNLTLLIYSGLGILTMVTLISLNMHL
WATKFAFKFLSLTTMLMILLGVLNLNKTKDTLYFLIAVMCSMLGLLITTFSVWGVIPYNY
YSYNGAVFGVVFEATILAVIVAYRLKDFEQQRITAEYLSSYDPLMNLFNRRSFMAAGHQC
IQQSNRTKKILSFVMMDIDHFKQINDTYGHHIGDLTLSHIAKLLKRHTRENDIIARWGGE
EMVILLPDTNAEQALAYTEHLRATIAATPFRDEAQDIQITASFGIATRMNGESLETLYQL
ADKRLYRAKQQGRNRVEPQDRHLPITTQEQY
>A0A5P9J1L6|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MSEQLDALRKKLNSAVSQRQTIENTRQEQVRTLAQFIAKLSLVCKGMDIELDNRLAAFRK
LLHKGANYQDLLPVIDELTDLLSRHEANLEARFRALHQGVQAAGINLQKRKGIPAELRRT
LRHLLNTELVDAQTAVDFLPILERLVTIYDQVMASRSQQEDGDPSDNTQLQPLIDELNAL
SSEISLEGELAEHLRQLKSQINAASTIDSLLNASVEIMRVIVLSLSKERQSAQHFLAALN
HNLSELQQAIAKTSDRSKQLDSKISAVYRQIDENINHLSEQTAQATDIQTLKETVESKLS
ALTEQLLNKEKLEAQQRDTLSQALHSMQSQVEALEQQVAQYETKLERQRLVSLQDGLTKL
PNRIAFDERMDLELKHFKRHQAPLCLVVIDVDHFKSINDNYGHSAGDKTLQVLATAMKKS
IRSTDFIARFGGEEFVMLMPNVSIDNVVRPLEKLRHTIRSIPFKFKNEQVQITVSIGVTQ
INADDTALSAFDRADKALYEAKNAGRDRLILSS
>A0A2R4D6X4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Concord|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>U4E060|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo FTn2|TrEMBL
MPLPSRLQTPVLLTVAILFTLCAVVSVTQIVKSLDLLAVNEHSTGRAIVQLMLLHQEYMN
DAENYFRGLIEVDELLTSYDLTWSAFEILLVGSESANLMERQGRLEIIVDTFESFKELDP
TLDSFNEIHFSQYLAHGQQTSETINALLNEEFQRVSEKNYSRDLELVRLNSIMGYSYAGL
AICGSLLLYITLKDRRKISHLAYHDSLTGLANRAALQNQLIDLKRQNSAEFTVLLLDLDG
FKLVNDTYGHDVGDRLLKRISARLLKTCGEGDFIARLGGDEFAIIQHSQEEPQVLPEKII
ESLSKPIKVGSVDCKVGVSIGICLASEYQDTWVDILKAADIAMYQAKSNGGNSYDFFDDA
A
>A0A6L6Y699|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. 10-1|TrEMBL
MNKPLWVRKLRRFSSPGHVVNFCFVAVLFFSTLLIWREIMVLEEAYVDNQRNNLANVAHE
MDGLLQFNIDRMIFFRNGMQSALETPLDFTILRNAEQEYMSRRHEAIWSVALHNRRTLPV
YGVSDAFVDKANTLSRDNPLSGNELMATLELGYLLRLTNNNRGFTERMLYVSRSGFFIST
ETLKNTAQALERYSDATRSPWFTRQAQRTNPGRGVVWQTFPEEGALRDAQVVTASVPLDF
RHYWHGVLAMDFSVREMKAFLVSAAKGGQDGEYQLYDNRLNLIASSAPGTVLTLLSPREQ
EMLSYAFSHDNEGGMRLLTRYISWEKLHNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFARAIAAAGECERGR
RPLAVIQLDLDYFKRVNDLHGHQSGDRVLSLVAGTIACNIREGDLAGRVGGEEFCVVMPD
TTLQEAAAIAERIRIRINSREILLCDNTSLRISASLGVSCSEDSAEANFENLQSIADRRL
YLAKQNGRNQVCFAG
>A0A1Y6MHU2|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MSKAEQHILKNKTSKWHTDHILCSNDMIRRCLVIFFNLLILVIIVGFSLRQEINETRLYI
EANLNQIKNMTDSLAYRNKRYANTATKAIANMDEYNKKLQVLAEIHYYPKLKEFGFNRGI
YSNNLFNGSLVGPGFPNQLIQKDTHLFAVLDELWAEQQHHPIVYNYYYVSHTLKYFYLSS
KVPVDKFNTTKEYFSTDFYYKQRSQSQQLNELQKGMYYTYPYLDFFSKEMVVTIKSPVYK
NNKIAGDIGIDIPVKSLIQSIILPQELKSSLNFYLYVIDKKKKIEIYNGYSNRLLPSIPV
HTYLNKNTLIFANISPWFFVNFAIKITILGLSLLIILNYMNTILKRHKFQKQRYQLEAYT
DLLTGLFNRRVMDTIIKDIVTENNKNGQPTALIIFDANDFKIINDSYGHDIGDLALKHIS
STITDMTRDSDICIRLGGDEFCVVLPNADLEQALIMADRLELAIFSSYFCHYNIKISIST
GCTVIEKNESLHNALVRADKILYKNKKNKTENKKALQKQLNNYIFKSPPNFPKQE
>A0A653KL58|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MDASILLKLDVFTLMVMALGGYSLGFITLSIIWLTHREIPGLGFWWWSSLCALAAQSLFS
LQAFMPNLAGIWLANLLITVCIALMPLALQRFFGKPLSWGASALFMLVYVLILSWSILFN
DHMAPRVLLACLSYMVLGAVIVFLIWRHGYPAYLPAVLVFTVVNILLYGFNLMRMGFLLE
GDARVLMDQSGVNVLPFLSMLMGSYLSTFGVLLLCTQYRALALRQQASHDSLTGLLNRRG
FMEQMGARRIGEFGALAVLDLDDFKQVNDRHGHEIGDRVLEAVGAYLGAQPELVASRFGG
EEFVLLLPREDEQAQQARCERILQDLAALDLNGIRITVSMGLARCQHDWHFDTLFSQADG
ALYQAKRAGKNRICRLA
>A0A734HIL6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:l,z13,z28:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAT
>A0A449IQ95|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fragi|TrEMBL
MPMTDSFKPSRPLPVNLRGLILCIVLASVLATLCNSLVVAYRVQRDALIHSTLESNAAYA
AKVASSIGEFLRAAHNNLNYSAKILGKHWDDPQVLHEEALRLEAQDQYFNSVEILDANGK
VLASNPPQAQIVGSNVPASGIRQALQERRALVSSTYVSRQGNLIVFVSEPVFSKAGVFLG
AVVGSIYLLDQSALHTVISSHFHHEGTFAFVADSNRRLLYHPNPARISEVLGENLAVDAA
LGGERGSMEIRNSEGVEMLAGYSQVPDSNWAVVVQQPREHSQATLRRLMHDMITGMIPAG
LLGMVLVFVGTTLIARPLRLLSAAAQQLSAPQTTELLQRINAWYHDASAIRQAMLAGVQL
LQQKLGRLSHEAQSDPLTGLANRRAMEELLSVLEQTQQPYTVLALDIDHFKRVNDTFGHD
AGDVALKQVAEILKQNSRANDLACRSGGEEFSLLLPDTTQETARAIAERIRQSIADARIP
QVGNLTISIGVASKAGAPMTPQQVLKLADERLYRAKESGRNRVVSA
>A0A6I6DX82|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 119287|TrEMBL
MNKEITSAPRPTFKRTLRRISIISVLITMTLIWLLLCIASVVTLKQYAQRNLELTSATMS
RSLEAALVFNDATAANEALASLGKQGQFSAAELLDRYDHRFASWSMGPNDKADPLSQLAS
QWLFPHPIRQRIWHNNLPIGELHLTARDSLIGHFLWTSLAVLTGCLLFASLVAITITRAL
HNGVVTALQNITDVVHDVRTNRNFSRRVSEERIDEFHRFGQDFNSLLDEMEEWQLKLQAK
NAQLMRTAMHDPLTGLANRAAFRTRIAALMSDSSARTNSALLFLDGDDFKRINDTWGHAA
GDCVLIEVARRMVEFGGEQHQSYRLGGDEFAIILYGVHSEHEVLRLCAALTQQFSPSYDL
HNGFSSRMSLSIGFALSWQHHSVEALLEQADRNMYLVKHQRSKNHTVERNTLC
>A0A517XEQ3|diguanylate cyclase|EC 2.7.7.65|Gimesia maris|TrEMBL
MSYLIASIIEVFTHNVSQGVTNASVAAIAGVCLLQYIVYTLKMSAVRKENEQFQRNLSEF
EVELQDIQSDRAMTLIENHILREFVSQSDFDQAIELLLKRYVPSLRDGFGLYLNHIDGEF
KLRESRGVSRNTKAVYDIDRSLLKQLRNQNVLVLRGEKLRESSVYQCFHDQDKARIQKLC
LLAVYDKKDISGIFITTDLYPEGVDEVQQIKLAKRLLICVSRNIVKNQDFESHRFELRVT
REQLELRSLADQQFKTPVIMLEEFLDRLRQLTNSSRAGLFLSTPGDVSGCKAIVECGITL
QSGVKARWREHEMNLVQLGLNSGENTSLSGDQLENHGIRSLVGAALISPLITNRKRIGVL
CLTSQDSQPYDERSLRLISWASQFLSNTLLKVLSHATIERQAKQDGLTGLVNRRSFDELF
EDQFQRAQSAEMACSLILIDLDHFKSVNDTYGHQAGDEVLRRVAQILRERIQEIRSSDNV
IAARYGGEELAILLPEVGLTGTERIAEVIRHSIESSVIKFNEVHIPVTASLGISTYSPHI
MDSVQAMLAAADSALYQAKAEGRNRVCSLTSTPV
>A0A8H8Z7Y0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVHSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9DGK7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSPEQRRAICEAFESANNTH
GLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKF
HYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQR
TKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDI
IINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHF
RLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLG
HQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIA
PQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A380AVN3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIQSTRISLGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNEKTNVKLIPQMNYLMVVVALFFLNAIIFLFMLMKYFTNKQILP
TLILSLALLSGLIYLVETIVVIHKPISDSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHNI
>A0A447W879|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MLFDLDSFKDVNDTLGHDAGDKLLQDLASRLSFFRKTSETLYRLGGDEFAMLSYDLTEEM
ALERANVIREKISQPYQIYDAAD
>A0A3S4HWP3|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MKWMGCCNLISIVCSFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTL
TVYGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNNNRIFSERMSYVSRSGFYT
TTDAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPL
DYEHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTPLSPK
EQEQLRYALTNDNHGGIRQLTRYISWEKIRNFDGVLLHIHTLKEGVRGDFGTISIALTLM
WLMFTLMLIVSWGVIRRMVINMSVLQASLEWQAWHDALTRLLNRGALFERAIAAARSCRR
NNQPISVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREQDIAGRVGGEEFCIVL
PNTQLPQARAIAERIRLRIHSREILLHNSVSLRISASLGISSSETSDEFNFEELQSIADH
RLYLAKQNGRNRVCSAG
>A0A2Z5SG57|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MEPYLPPPLRVLIIEDSEDDYFLLVRALKREFDIVPERVDSEESLRANLCDKRWDIVLSD
YFMPQFDALAALTLIQSMNLDIPFIIVSGKIGEFEAVKAMKAGAHDYIMKGDYTRLIPAI
RRELREAVIRQEQRRTDHELREQLHFRQALIDAIPAPIYFMDTTGIFLGCNKAFETFSGH
TQDEIVGKTIYDLMPPSLAKHTDSADRELFEHGGIQIYESVISFADGALHDVIFYKATFT
TTEKNIGGLVGTILDITERKQTEEKLRYMSTHDPLTGLYNRAYFQEEMERLEQGRQFPVS
VVVFDVDRLKYVNDSQGHAAGDELLIRAALVLKGAFRAEDVVARIGGDEFAVLLPSADAD
VVQEALRRVIGKIEQSQTEDHPVPLSISFGAATASKGDRLEEVLKLADRRMYENKFKKCC
VLPA
>A0A379AGY4|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MSLDIYTLFVCELYVLGFLSIIMFFAWIGSQYDRVLGFTCLSLVFTLIAVFLSSLRSSGL
HFLPVAVGNVLVMLAYGGLLNAFRRFCGKPIGTHWLLGALLWALLCCFPAFYYSLPKRVL
VLCIACIAYTAALIQLVWLARATLKVTFWPAQLLLWIHLLFHLARLFLDSAIPSTLPGAI
GGSNFSIYVILESILFVIGLTFTILAMVNEQMQSVLKHASMHDPLTSVWNRRALFNEAEK
IVARCRRQNRPFSAILFDLDHFKSINDRYGHQQGDQILIHFCDIVRGLIPAEGRFARLGG
EEFAAIIPAAATEAEAWCETIRREVCASQPNSIAYSVSIGFATVTHQQQGFDDLLALADK
ALYHAKASGRNRIAQHPVTAGIS
>A0A379ADG0|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MLLPGTALDEAQIIAERVRLGIAEAWLTDVGRITLSIGVAAWNGSQDVGLEGSLKQADAA
LYEAKNAGRNCVIVAAA
>A0A7W2E433|diguanylate cyclase|EC 2.7.7.65|Pectobacterium aroidearum|TrEMBL
MSASPPTFLTVDVRRSGLRFSQRVYIPRIVGTILCSLFIASVLITKPIPVLLWGLLLLNA
FAWPHIAYLLSLRSRDPMRCEKRNLLFDVVFGGIWIGFMGVNLLPSAVIAAMVGMNGTAG
GGIKLFVQGILLQCVACVSVLVLFAVPVSLDTTPIQIYACVPMLLIYPIFLGYVTYNTAL
KLAEHKRMLMEVSIHDGMTNLYNRHHWERLLKHEFDLCQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVSRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYMDWLKSADMALYRAKNKGRRRTEVA
>A0A6N2Z1S2|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGAINLTYTAINVIEAVVGALLLRKLLPWYNPLQN
LSDWIRLAMGSALVPPLVGGILVIFLVPGPEPLRDFIVWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTMAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVVSLMIAHNPEALTTQHEGPMINAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EARFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGERGPLMENIHSGDMSRSDIDQDVVLNCRTGGAFDIHYSITPLSTLDGQSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSMMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
TGRLVHSINDYHFMWEGRLHRIGASAGITLIDEHNHLASEVMSQADIACYASKNSGRGIV
TVYEPQQERDHSTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSDFFRTSAARIASKGMGIALPLSAAGLASVTLV
DELLDLLDKSPMPGRLLHLVIPAGVVCDSDENLQRGLQKLRQAGCRVILSQIGRDMDIFT
HLSPNMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A5W0Q4Q5|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDKMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1V4VSQ0|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MITRILVIRTLDVLKGLVNTGKIKTLAKNASAIFIQVFTSKANPQWVKNIETILHENLPG
AIIVGASTSGEIANGQLFTNSTVISITFFKETTVKAFILDAATGGEVDLGKTLRADIENT
CAKIAGVLLLTTTTTMDVSDFLTGFADAQVAYPVFGGGAGEYSSPVSEMKALIFCNSRHT
FKGVVAVAFLGDGIKIETHNYLGWHPLGKEMVITEVNGYWVKKIDGQPAFKIYRRYLDIQ
NDKSFQHNAIVFPLMVKRDGRQYARPAMAVNEENAILFLADLKKGETVLFGYGDPNTIIE
QAAAVQSLLAAFEPESIFLYSCAARRAFLHNDVELETKPFENIAPTSGFYTHGEINSSPN
SINHLNYTMVAVGMKERNYGGKAAQIQNGHRKPLFQEDADLFAYQHSRFISRLLHFIRAV
TDELEIANKETRRLAETDLLTQAYNRVKACELLNSEKNRCERYGSEFSIIILDIDFFKEV
NDTYRHIAGDAFLVNIVKIIKKQVRAPDMLSRWGGEEFLIAMPETGLDGALVVAEKIRAA
VEQTVFPGAGHQTCSLGVTSFKKGERIEELIERADAALYEAKQSGRNRVIAK
>A0A1C3J865|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MKLSLKYTMGLVLLACSMLPVYLAGQLILNKQNQSSLEQKETKLDNSTTGIRQTVQEQIN
LTASLTQWYSQDRSLIKAGGNIFFSSVVWDKMDSFNALAESVSATYILDQNWKPIYDSKG
SLYHFEQSQLLESLKRPQSVYGQGKLFHTEFTETEVADNATAGIAFVAPILPYRLIEGST
YTPQGYLVVLMGYDRLNTKVTPFLYQNESVEFNYVDSTDAQSSEQSANIISIDSKFFTDK
LVLNVKHHISDSARLLEMQQAQVVFVRILVATLAIAIVFALFLSRWFSGQLNLLAESVKS
YSHNQSPTHSVDEHRFTEFVTLSRLLETMWGRIQYQVRELTESNDKLERFNVQLEDLVEE
KTSKLTYSLAREESQKHRILKIVQFASSRQAAEYRLIPQMVDQELKTLLVQHSIQFHFNR
TGEADLILCDSQGTAIGYFCSSSFALLSEEDLLIFDMYQKQLAGWLELENITRINMPTGC
LNRKAFNEDFEFSKRSINDNQNQISLIIIDINGLKTTNDVHGHEVGDELIQRCVDVISHE
LTPASNLYRLGGDEFTVLTLTSGKSNSLNVAEMAEQLYIAQEQQAIETKAGISIPVRFSI
GAASSDSTDVEQLFSVADENMYQQKRRYYQTLSVFGK
>A0A485DMM4|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSELDSLSTLYRDACVTYATLSIGYFALSKNSPFSYNGEVWKRIVFGLIAGLVSLYLNQD
QWVISGAYFYSFELIPIILVTFYGGWLSGLTALVINFTFTGWVTLDNVLITIVIIPLLFS
KVWEKKSSRIFYTTIILIAIYRMLTAVLLVPNTLFWTQIVVYQLISALCLAICYHALNFK
ERHIYAYFAMKDRANIDKLTQLNNRSSADYRLNSINHNRQACGLLILDLDHFKSVNDTYG
HDGGDILLTEVGKLLMTAVRDEDFVGRYGGEEFIIITHSHDPQAIKAVAERIRQRVESLD
VQLPDGRKLKATISIGASLFLPGMSMLKALKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRMVKDRRRRS
>A0A736R393|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 45:g,z51:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFALVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6N3ABR0|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MSGMRTVNNRYLIDEEISNEENYCKYTVRDCESYDRFILIILKNDFTYEKTQEYLLNKFK
TIKNLNCSNVINLLEFQIIYNIDGIKLDKYQYGYLMEYIDVPVSVQEYIGVCTTKEKIDI
FMELCAVINTLNIKGYIFKDITWKDIVLFYDKTKNVHLKIDNILQNEISKVSLINVSRNE
KPYPYNIENVDESTILKDNISEIIQFLDKMFTDEELYGELKELSDIKKRFNQVHTINKSY
NLNYFIKCVNNALGKKYDYFLKNTLNIIEDNIDIIGREEEIKIIEKNYKNILESKIKYKV
IGFNGDTGSGKTRLLNEIKYILENKYFKNITYIDNFISKSKNETYKNILGYIKNKCDGAL
YDKYDIYIKKFISTCLEGDYDNVLNYDNNQQFQLINRVGKFIREYTNSNPLVLLIDDLDK
KNKGLKELVRYLSFMGNSLENIMIVFSLNENSCDDEFLEYLNELKMVEQYEEYKINFFNQ
YDTTKMIKNILNTNKSLGKLSNKIYSETLGNPQYIREVIEELYSNDILYFDEESSKWRTH
VNIREILIPKTLEKKLETSLSSLNEYEIGILKLLSIYETPLSEKIIFKIINNIEQIRIYN
TLKNKGYFIDKISDQGLLVGFSNNLLRNILYLKLDKEKKRCMHKDAANLLKETLHSTDYY
MEEFLFHLEECFDFETLCIYALKYAEKLKSCANYEKALSYYKKVLKYSKSDRIEAAIRIA
KIHEKLSNHKKSFEYYEKAKKIAIEEKNINIKSYVMLEMVIIQINSSININSDIEKTLID
IRISLDNINSPKEEAYYNYALSLKYRAQFNYKMAIESAKKALNICKNNEINGDIYAWSMV
TLATIYIKYSMYNEAKELFLKALEVFAKNKNNNGIIISRIMSTYIDSEEGKPYKSILEEY
HDIERLSNKLKLYKRTILTLIYISKFYISQDKYQEAEECLLKALAIEREEGIDFYSLNIC
TNLCIVYLNIGKLKLAVKYYSLVKQMQKVVPLLEEDIISINSTNTFYNMFIHNNIKAYEY
LNEEFNFNKITRCVYYMLKLYICNNDGEIRKTYKELLEKINGLNNNNRKLKIRVSSIKTI
LDLGYYETAKEFFYEMNEYPKDYNTEGIYVYLEFKFKNRNSYNFLINKALRLCTVINDKR
ICADLYGVIAEKYEELSCNVFALNNYYESIGLHIDIINILNEEDKIIYANNSRFLDVRKK
LIFCLREKMNYKMVYSNIEKINYIEELNLIIDEISIKNTLSDRNMYKLMQKTYEKCYYND
FSSSYDLFNSFTSDILENMENVMKHMARITLADKAILVIENSNGENNIICTYRLSDKKET
DRYFSLKLESEEDVIVVSNNHNRLDHLNDEVLKHGIKSCIYMKLRNKDKSINSESSVNGQ
LILIATNAVNYINSESKKKIEKFKPFLTFLLEKYKLTISSTLDKLTSVYNRKYFEESLVY
LLEKSSFNNSEFAVIMFDIDDFKGVNDKYGHQVGDEVLIKLTKEVKRSIGRSDIIGRYGG
EEFVVLLPSVDKLKAINMAEKIRNNVEDARILGDKRKVTISIGIAMSGHERINSEEIVNR
ADQALYMAKHEGKNRYVLWDGEKIISKNTNTNNELSGILSGNSAKDYNFISIIKDVAVIV
KSKNSKENKMYEFVLKIMQIIECDSVTLFIIDNNTIINIMSKDRLKDGWNISEKFNFKLV
YQTIENKKGMYKVDWDNIGKQDKYGIPDWKSVCIVPVVCNEEIIALIYLSVSVNKKEFTV
IDLNKLNFFADMGIPIFE
>A0A4P7TK62|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGNLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A222NYJ0|diguanylate cyclase|EC 2.7.7.65|Legionella clemsonensis|TrEMBL
MFEKSKPIRLNLLVLNFLFLIALLTLGTISYLSYSQLKSLIEANLQVNHTYEVLGKIDAS
LYAFAEIEADQRAYLVSGNKNFLKDMTITRPKLNEYLQASLALTKNNHKQNERIRRYAAL
IEERLVLLHQVIDLKANNKLNTPEGLALFNRSSQVSNEAKSLAQEIKSVEEVLLSERNRL
TINSAQIGSVLLIIGSTLGLVFLIIPFILANIELINRKIIEHKNRHIRTHLRQIIESTKD
MIAALDSKNRFEIFNDAYQQEFRRLFSKTLSIGMDINDALADLPQNKRYLVEVWKSSLQP
DETAQVVEVEHEHGKNVYELSASQIKSEHNEMKGVVHTVCDITSRVIEHSKLQESYEKLS
EGMKKLQLKNEQITLLVDMSDIMLAANSQEELSRVMAKYAHSLLTFSSGYLFIMHPSKNY
LEKAVSWGKPHSQESIIIPERCWAIRLGRIHFIKKAEMELVCDHIDISGGKKLPAFICVP
LMAQNDIYGLLSIEVSDSSFSLNEESRLIITAFAELTALALANVRLRENLRYQSIRDPLT
GLYNRRYLEDALFKQIHQAERSQLSFALLMLDIDHFKKINDNYGHDAGDSTLREVGKILE
GYTRQGDITARYGGEEFIIMLHNIDLDKAKKQAEKIRVAVSKLQIKYGAQPIVPITVSIG
IAVFPTDSKNKEELIELADKALYSAKASGKNKVVAISENK
>A0A083ZVD0|diguanylate cyclase|EC 2.7.7.65|Serratia sp. DD3|TrEMBL
MIEPCMPANEPLRQCVLDSLHILDSRATEKLDRITRLAASYFGVPIALISLIDRDRQWFL
SRFGLDAPQTPRNISFCGHTILQRGTFIVPNTALDLRFADNPLVQGPPHIGFYAGQPLLS
LDGLPLGTLCIIDQQPHDFSTKQSTDLQDFAAVIEEYLHNIERDFYTESLKLNLERSEAL
FEQTFSQAAVGMALVSLEGYWLRVNPRICDILGYSEPELMARTFQDITHPDDLDNDLELL
RQLLANEISTYSMEKRYFRFDGTLVWVELTVALNRLSDGSPHHLISVLVDISERKLAENN
LRILQQELEERVISRTQELNTVVNKLNLEIESRVNAQYQLNAEKERLRAITDNMPALISQ
VGTDEVYQFANSAYQRWFGIDEASLKTMTLRQFMGEQAYLVAKPMIEKALQGETVSFENE
LKTQAGLLAVHTTLVPCETQGFYILSMNISELKRLQQRLEYDVTHDMLTGLPNRRAFIHH
LELSRAECLATGLPMAVLFIDLDGFKQINDNLGHEFGDNVLKIFANLLSDCIQNRGFVAR
LAGDEFTAVLGQLTDPEAQIRAFCQQVLAQLAELAFIAGHAINVSASIGASIYTGDDTTI
KMLLLQADQAMYRAKSAGKSNYLIHGSKQA
>A0A829DJ90|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2875150|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQERLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1A8TI79|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MCSYNLLERLLNQGELETDVDFGDKYTVNLVLMLVMLVDLSLMLFFSLGRPDLFACFSYF
ISFVFSIWFFFVNRSKWLRWVRIATPFLVIVQIVFSCFFLLGSGSGLQWLLVMFSSYSFL
SFQRNERAWQASTIVSSFLAFVLCELYAPRSGLLLDKSEQVVSVILVFVYSLLAFGLAVQ
ALVGRLFRVNMKLRELAERDVLTGLPNRRKVLNEALAIFNEALESSSACSFAIIDFDHFK
RVNDSYGHEAGDLVLQKGAEAMSICLRKHDKIGRYGGEEFVIIMPNTDGSEAMSKMELLR
ASIESLNIVSSHGIRIPVTVSIGVASMSKETAIFEDVLALADKALYKAKKAGRNKVFR
>A0A8B4FT98|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MPKHMNHIVKRLIVYICICLLAGVGMTGLTDFFHTRFNSTSSTLFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVAFGFACSALLMLGTLSSYPDWLSCNPSPVVKQNDAVIYYFF
RNIMMAILFMSSIILYYFRRRIMHSWKAHVMTFAACIVLVLTIIFLSWLYSSHSPKLSIN
FIDDLNHTFTPLWQSIISWLLMAVWFITLILIICLSKLRNIFWYSGAFFCSAYLFTLFRL
LSTVGELDQAWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVKAQHPLSVIISDLDHFKRINDNYGHIAGDKVIQFAASVLVSHSR
KDDVAARIGGEEFALLLVNTSENEAQAIAERIRLAVSAEQTALPERMTISMGVYTTHDRS
VTAEECVQRADEAMYEAKNSGRNRVVIWRRQGG
>A0A8I2BGD4|diguanylate cyclase|EC 2.7.7.65|Thalassospira sp|TrEMBL
MPGSVANGGMADAERDILAELDKALGEHVALLLRWNRKLVLPDSPAPDTEDDDHDCDFGA
WYALNRHNRLIDQPAMHALATTHQQLHDSAKRLLSARDVDNEVDSAEFDMMALRAESFFA
QLRRLERAFRTARSDVDPLTGTYNRQTMMGDLNAERERAIRTEVPTAIALVDLDHFKSVN
DTYGHQAGDIVLQSVAGILQSHVRPFDKVYRYGGEEFLICLPNADMKQCARVLERLRRVI
EASPVTISDETILPVTASIGAAPMTKSRTTEQIIEKADRALYAAKEGGRNRVRVWRSPDG
KAAPTAPKHGKNAP
>A0A380WJB1|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MVVASRIAERFNGLSVLGQSCAIVAAATVGADLLTLIFYAIFFSDRLLLDLVLTSLIVVA
VAFPLSYFFMSRSAKLVELAAELDRANRLDDLTALLNRKTFLLQSRQVLSAHDGDDGAGM
LLFIDADHFKAINDRHGHAMGDAVLQEIGAALTSSIGEQDIAGRLGGEEFVVLLRGANPD
KATLVCERLRRKVKGIAAVVGMSGREVTVSIGVSKHQPRQSLDALLLAADRNLYLAKANG
RDRIVNTDGKLAAA
>A0A1V5DGI3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MKTTKQILQSTWTTPNVNRENMTAVLANPEQVFSFLDASQNRIGKKISHHTSLGTALILR
SVCDRAPIAMSVVRIEDGKVLLSNPAMQKLLGYTRQELAGMLFTQFTHPEDVEKQKEVYL
KIKSRQSVSFDMKKRYVRKDGTSFAAHLVSTVIPRSSVKAVVMIGMIMETK
>A0A1V5RFE0|diguanylate cyclase|EC 2.7.7.65|Candidatus Omnitrophica bacterium ADurb.Bin314|TrEMBL
MVGLFASATFIFFRQIISFVAGLAWGGVWVATAFAMFVSRGMWVFVLNPLLLIFSLFVFS
AIFSMTVGRREQERLFALATRDGLTGLYVIRHFRVLLNSAVVEACKKQTALSIILLDLDR
FKTINDTHGHLAGDAVLKKLAQIMQEIFPEEKKKKGKYVVGRYGGEEFIIMLRGCTLVET
AFGFGEKLRKRVEQEVFIHEDKVIPLTISLGVATLRPGETVPDMMVHRADEALYRAKTEG
RNRTCVELEIGRE
>A0A1J5RL28|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLQATLPEVFVSISLTEPVVVLKVSDCIDQLLGYQPVDFLSGNISFRQLIHTGDQDIAES
LFSSEFSQISGDFNIRLRQGNGHIRCVKGYFTKKLASTGVVLDLSLQDAKSLSQLTPHMM
PNFKAMMDNTNDYIYFKDRNHVFTGASQTLVSLTNPSEHWTDLLGQTDYDVFPEEYADIY
YELEKQVFAGIPIAHEIQETLDNAGKKGWVDNRKYPIQNESGEIIGLFGIARDITDSHLK
QQKIEQLVAEQSAILDNKLVGMVTAKARNITWANSAVETLLGYKKGALVGAPTRQLYVSQ
DEYEAVGAAYANIKLEGVIRRQCEFLRHDGQSIWVDMHGMVLSEADGISLWIMVDVTARK
LAEDALLKSEAKFRALYDSNGEAAMLLDEHGFFDCNKAALKLFGIKTIEEFCLNSPADLS
PLQQPCGTNSEVLAKQKIVEAMEIGNLRFEWTHKRIDTDETFPAEVLLSVIELDGRAVIM
AAVRDTTESKRSELLLRASEQQLSFVLEGSNLGFWDWDIQSGHVQRNHIWAEMLGYTFEE
VQLTTQQWTDFLHPDDVQNAWKSIQEHLEGKTSVHESTYRMRTKSGDYKWVLDRARVVQR
DVNGRPTRMAGTHADVTEQKLAENDLRIAAAAFETQDGMFVTDVDGTILRVNQAYTAITG
YTAADAVGKNPRILKSGRHDSEFYASMWQSLASTGLWSGEVWNKRKGGEVYPEYQTITAV
KSTDGITTHYVASFADITERIRMQEELKNRAEKDFLTGLTNRRHFIELAEAELIRAQRYS
SPLSMLMMDIDFFKCINDTYGHKAGDLVLQKLAVVCKEVLREIDVIGRLGGEEFSVLLPE
TGVLRAVEVAGRLRQALESARVVVDEVNHEVTKPLCFTVSIGVAAMSSVDATVDSMLLQA
DVALYKAKNSGRNKVVANV
>A0A078LVF4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas saudiphocaensis|TrEMBL
MQQISNEQLAAEWQSLLQRFPVQAGIELKAVAEANSQGLAEHFYQEMLADPQAALFLSHE
QVQERLSDSMERWVQRVLSANGDEDLEPLIELQRTIGAVHARIEIPVSLVLRGARHLKGR
LRTLIEARVKEEILRRDAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFSVAQNL
GAEKERQRAALLDWENQLMFNLAVGSSLSSLPRLTSSEFGLWFRHKAAHAFQGSPNASGI
LETILKIDKELQLLGEAGVDQGNSTLHSIREKTRSIRFLLDNLFEQASELEAGRDVLTRL
LTRKFLPVVMNKEMLYSRQAGGSFGVLVIDVDNFKQINDRYGHDGGDQVLLQIATTLSNN
TRGGDYAFRLGGEEFLLVLVDVNTEKVMKAAEKLRSHIAAERFRLPQGEMLNVTVSIGVA
VHDGHPDYEHLLRRADQALYEAKRNGRNRCVLAPSS
>A0A1J5P1P8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAIADYLFDKVEHLTVSFGVVIYNPEDDLNSLLKRVDDALYLAKQNGRNRVEALQREEIV
NPAS
>A0A1J5QUW7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MINVTSEELDRILVITKNALSLHDQWREGLLRTLICKLPVATHYIAEDAHQKCEFGYWFY
SKSTSHLRSLPALSKIGELHQAMHLSAREICIRNKGTGMVDEEDYDQYLGRVSQFREELL
ALQYRVSYTLQNIDSLTGAYNHHKLMLDLMAEKLRLKENKEQHSLLLMDFDLKEINQSHG
RNIGDKVLSMAILSIREELTPGDQIYRNGGAEFVISQPSKSMGDTELVKELLLQRMSEAL
IGCAGEGAPSLKIHYGIVELKPNANLDELLDRSARSTTTITL
>A0A1J5RV71|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MMARTMVAQTEGASREKTLSLLTALSDYTRYHFREEAQLMRMWDIDDAQRTTHLKAHERF
IAFLGQVGKLAVSHPAEFTVDLLTFLAQWLLHHIMGLDASMARAIRAKQGVVPTSAAEPN
DNAAQQYLVDLMGQLTDNLGQRTFDLLEQRDQLLAQRQELLGLQNLYRALLHSAEALIHS
PSEAEMLKRLCETLTLNTDFHTVWIGRPGSSMVFDILALAGSGEQLVRETPPRLDTSPET
SIIVRAWNSQRVVVCNEPQGDAGLRPWHAKFASHGWASLLAAPVMRGPCPWAVMVFVSGR
SGAFEEGTVILCTRIADLLSHGLNEFDRKEQLVHLEQQEALAARTDALTKLPNRFAMELY
LPQAMERARRHGTALAVGMIDLDDFKPVNDRFGHAAGDVLLQEIAHRLQAQLRGSDYLAR
LGGDEFVLVFEDLDTANAEAQLAVMLKRLQHVIQEPFDLGQERNARVGMTLGLAIFPGNG
EDSDTLLRNADAAMYQAKARKNHRFQWWNLWREETTASGATPK
>A0A1J5SB65|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKYEHDRQASEEILRLLIQKMAEHPAAFTPQNYAVWYEYVTGINPALSETLVRQVGSGER
LDDTTIEGLYLKYVSECNMDVEWALREDIQHLLRKLAESTIETEKQAYRFDTSLHAYGDT
LKQNPDPVSLSALIKNMADDTSKMIDSMQDLQSELAASKQKVEKLHLELHSARGEALIDP
LTGILNRRGFENSAKIALSNQAALGSGICLLMVDIDHFKTINDTYGHLFGDKVIRAVANT
LKSKVRGQDSVGRMGGEEFALLLAETDISGACTVAENMRKTVEGCQIHRVDAQEKIGGIT
ISVGVAEYVSGNSLLDLLGHADKALYASKKQGRNRTTVYADIKAL
>A0A1J5QIU0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MRPRSRRDKFHCVHVSTKNIVDTMITELSINQQRGTTGRIPWGYLATMRILSSAAFAGLA
CMHNERRSLQTAFLMLGAMLAIPPIFFLVTHPLLASLGSNVDIATRLIIKLYALLPFIVI
AGLSVFPLTLSEVLIASVSVFSIVAISTAYQPDISVDDLIATGWMLILVTGVSGFSGMSQ
LHYIITLVNQACLDTVTGAFTRRSGKETIDLQFRLSARTETPLTVMFVDIDNFKSINDSY
GHEVGDRVLHHVAMKLSACLRKSDVLVRWGGEEFLILLPDSASDGVQHIIRRVSLSGIGL
RPDGHPITVSAGVAERMADDCADWDQLIDLADKRMYQSKSQGKNRCTGYDLETCMAPLID
TSSLISEKSI
>A0A735ZUQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVTPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3S4VAW6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MRVVLFALLLSLCSQASAHAETALLSASDSGRGLNAHVTLLADPGAELNIDDLQRPDVKA
RFVPAEGKASVGQSPHPWWIRVSLQRESDAPFQWWLEVGSVTLKDLRIYLPDGNGGWIER
QSGELVGFNEGRDHAYRRMLFRLPPLGDSQPVTFYLRSYDPAGNSFPLKVWQLDALQEQA
VGENLFLGLIYGVILAMLLYNLFIFLSLRDSAYFWYVVTTTGALLMILAMTGHGFQYLWP
NDPVPFWLDRISIPALWGFSACRFTQTLLQTRQFVPWAHRLLTFALTLYVTAVLLNAFGW
RAFGAWVFVALALTAIPASLWASFRRWRQGYFPALLYLLGFGVILGSVNLLLLRATGVVQ
PAAWNAYLFPLAVTAESILFSFALAYRIQILKQERAAALEHADQEKSARLRQVQASAEQL
SLAVETRTAELAEANRHLSEREVELKQVAFHDALTELPNRRYLIERVEMALSDARRRGES
IALLLIDLDHFKPINDGHGHDAGDLLLRTLSQRLRDLVRSSDMAARLGGDEFAVLLTGPN
VEQDAAQIAERLLHELSQPVPYRDVTLAVTISVGAAFFPRHADGFSQLYKAADEALYRAK
HQGRGNWVQQEEQARPADQPM
>A0A379ZKR6|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MLEPCFPENEAERLSVLNSLNVLDSNSVEKLDRITRLAAKYFGVTIALVSLIDRDRQWFL
SRYGLDARETPRNISFCGHAILQREALVVPDTANDPRFFDNPLVIGGPRIGFYVGQPLLS
LDGLPLGTLCIIDSQPQPFSPEQLADLHDFAAVVEEYLQSIERHVYTENLKSNLQRSEAL
FEQTFAQAAVGMALVSLQGYWLRVNPRICEMLRYSERELMDRTFQDITYPLDLNTDLEKL
QQLLRNEISTYSLEKRYFRADGSIVWVQLTVALNRLPNGKPDHFISVIVDISERKAAEAD
LFALQHELEQRVEIRTRELNVVVKKLNEEIETRVLAEYQLSAEKERLRAITDNMPALISQ
IDGNERYLFANSAYKTWFGLEESCLRGMTVRDFMGENVYQIAKPMIDRALAGEMVSFENE
LQTQKGLLMIHTTLVPCETQGFYILSMDITELKRLQQRLEYDATHDMLTGLTNRRAFLRR
LSGTLQACCHQRQMALLFIDLDGFKTLNDSYGHDFGDAILKTFATLLSACAGEHHSVSRL
AGDEFTVILWPLTDPRREVSEFCENVLAQLAKITQIGPQKVRLSASIGAAISPRGDVTEE
MLLTRADGAMYQAKSAGKGTYAICEL
>A0A8F9MZA4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8F9N712|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A5C6DAD8|diguanylate cyclase|EC 2.7.7.65|Candidatus Brocadiaceae bacterium S225|TrEMBL
MMMNATESREETVRYVRLIFPLMTKHGIPITPKNYTTWYYYVSGRNKELQEAIDSITESN
KPYTKETNEEIYQRFVVEKEENTLKGIRKKLQQTLLTVFGELKELSGQTEEYESTALENV
EKLTDDMSIRDIRNILDEVIVATKKIRRFGEATQQRLKETTKTLHVMQKEFEHAKSELLQ
DFLTGVMNRKGFDETLEKLTNESTGNLCVLILDIDHFKKFNDMHGHIVGDEVLKFVAKNI
RKNVKGKDIVSRIGGEEFAVILPETPLLGAATVAENIRASIARLKLERKGKTEILGMITV
SIGVAQYRQGEPLKDFVGRADQALYSAKNTGRNRVAAESMISNRVE
>A0A1E3ASP4|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKNRVKKQAVKSAEALSYSKVRRAFIVCLFLGILCFLLQNAFLAYTNMKQTVKTIQQSVS
AQISEKVNESLKLLESLASLDLFYEPDTPWEEKVAVLDKINEFYGYMFICFVDQDIVVYT
LGEEPASLASREHMQKVYASKQPYVTDSFVAGADGKTLNYTVIVPLLKDGVMTGSLFATI
VLDDISGLLNEITSTTKAEAVLISSKGLVMCSTNNLTYGTSILDILSNYKLLHTTANQLE
EQMLNRHFGSFQSYNGFGLIYTEYGPVENSNWDILVTVNFWPVFLSMLPSAGFAVLGMLL
IMAALYYFVNRHARLQSQTIENMVKSVQQIKRKVYQGNDPSEQIDYENIIQLSSKGLNDD
LTGTFTRVIFLDRAEAMLKDKQDEQILALCFIDLDNLKTLNDTNGHSAGDMALKKIGSIV
REYGVKYDGIAGRYGGDEFILILRDIDNHDELNTVLKELVDRLKFIIYCEDKEIEIHCSI
GASIWHKGLTLETLISNADKALYNVKCHGKANYSLFLNGGHDEI
>A0A6N2YVX9|diguanylate cyclase|EC 2.7.7.65|Eggerthella lenta|TrEMBL
MVSIPRYDDLATALREENIDIVAGVNDDDNTEIDKIVAMTAPYMTTSILLVYNKFVDPDR
LDGKSIALLWDQAETAPEGAPVQLYDTIEECLEAVNSGEVDYTYGTSYTTPYYLNIDELS
NILYLPTSTQSIDICFGLAQPVDPDLLVILNKALRSLNSAQLDSIIYDNSLIDQDEQINL
FIKDHLGEFALACISLLVLIIVLLALYLRSRMHAARAVREENLRFQELYRLANEQFFEYS
IKSDTLRISKSKSLLSSSYVDDATSMDDGSSYVSYENARQLIKHSANPELLDAFTSPSNA
VTEVLCREEANPDKDRKWIRITSHFVEDDAGKPISVIGKIANIDDEMREKMDLSERAHHD
GLTGLLNWQTFQETAGELLSNGTAGAVLVVDTDDFKGVNDTYGHLAGDRALQQTAAALTA
AFRPQDLIGRLGGDEFAICVNGRIDDERLASACAGIVKRGVTFTDQYGTEHEVTLSIGGV
ELHGKIASYQSAYRQADKALYRAKAAGKNRFVIGSYQAE
>A0A6L7EGQ6|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. Lac1|TrEMBL
MSDESKKYISVIFKEWLPLYDGLTPEVKAILKNIAAEQSEALATRFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKEQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDYQNGLATIRYAVMAITMAIEMMCHAYTLSHYRATKNEEAYRLYSLM
DNVPMEYGKQQASLSGWENSAIYNIVSENRADINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLIAQVDNYITGWKSSDSGAEYKNTQALLQSIHIHCQKISSQLGVIFSSLSQMQN
GKDSLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDSWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSTGYAVHTGHPDYNRLLRNADSALYVAKRSGRDCVKMHQDEQGPQH
>A0A1E3A6V6|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MDRAGKYLLKAQRMFPEDQDWEELRLGLTSLLGIYYDMRGDEQNAIDYYLKAVTIAEELG
DADRECVVLNNLAFAFQRHRCYEVALEFYQKAYWLQKNAGINPVRSILLENLAEVSLFLR
QYEEAKEYILEFEENEKDPLQRVVMGDKNWCCYYGAVGEREKALVYADRLLRNQDVINEN
KMTAFESYHMLCRSMMELREADYAGRFLEAMEEVSVGGGLDQVQTLEEMRIQYSLLFEPP
EKHSEAYCVFYKKNQQFRAKIDETIAAAMKTRIQLEQLMQQVEDMQSEQEILEREVNRDE
LTGAYNRRFLETLIREHTDGAAEESFAFIVMDVDCFKEYNDFYGHLKGDEALREIAACMM
EGARERIYASRYGGDEFVCVCIGLTEKEIRTYIEGVRARLHARAIPHEKSLCSGEVTLSA
GYAAGIVKTQIEVRQLLQLADHELYKSKNSGRNTFTGKRVDIL
>A0A727UBL9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3AZ76|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MSGKLIKCLASSALLITLLCIGALVYIRTDESRFHSETELQQINFLGTYEVDNNGKLLPF
NGSIDGLSHDRHHVTVTGTFSEDIPAGRQLMLRIDNLKVTIYAADKKIYSFGEKGTFPHY
ARSAGNGWDSLISPGISSDDYVRIELENLYTNHSDTAFSVFFQFMYYGYEGELITSLIRS
KAMELLLAVFIFCLGIIAIVYCILLYPLKKVVRQTFCFAGLSLSAGLWFFIDFNVQCYLI
PLPVFNNSLDIVCMIITSVFLVSYFILLLHTRWKILLAAEAALEFILLPAATAAQLMGIY
DYYDFLNVIIVFTILEGISIPAMILYENIRFSDKINHSLIDSLALVAGMFLQIFGEHREN
KTSLFWFKLGFFIFLILQFWHMAKSVKGIIADSTKAALLEEQKQELIEKVQKDPLTGLYN
KSATQKQVAGALRTGNPDSLAAFLMIDIDYFKKINDTLGHAAGDSVILIFAGNLRKQFRD
GDIVGRIGGDEFAVFIWVPDEVWICEKARKINAALAENITLESGACSITASIGIALAKCE
DAEFESLYHQADEALYRAKAAGRNQYSL
>A0A1E7WE17|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MDDHELRSLMAIEAAGMAIWDSSVVNGQIEECTIQWSARGAAMVGLPAQETLQPFTQFLA
LVHEDDRDELLDTMQMAVDARAEYHLGYRVRLADGTVRWLHADAKVLCGDGRHPDRTLGL
IRDVTGMVEHERLVNERERMAEVTLDCIGDGVITTDCHGAIRFMNRAAEQLTGWSRQRAA
GRDVNEVMPLVDEVDDTPLEHVAYKCLLRRETVGISSHAAMLTRDGRRIAVEDTAAPIRV
NSGGIVGAVVVFRDVTHQRALSSQLSWHASHDVLTGLFNRREFELHISHALHVSKQDNHT
HALLYIDLDRFKLVNDTAGHAAGDALLQILAKQLQERMRESDVLARLGGDELGVLLGYCR
MDQARRIAEEIRQLVKDFRFVWDVHSFDIGASIGMAEISADSTSVSDLMIAADEACYLAK
DQGRNRVHVYSPNDAAITRRHSEMMWVATLNDAMQQDLFTLYSMPIAPLRGNHMKHEEVL
LRLTDEGGDVIRPDRFIPAAERYHMMPMLDRWVIRAVCRHIAYSVGSQSQPVREEQHGRN
TETEVPISGISSVLAQEVGPTLYSVNLSGASMSDDALYQFIVSEFAVNRVDPAQICFEIT
ETAAIRNLLKAQDLISQLKLIGCRLSLDDFGSGLSSFGYLKTLPVDFLKVDGSFVRDIAS
NPVHRAMVESIQKVAQVIGIQTIAEFVEDASTLEVISEIGIDFAQGYAVGRERALDSADT
>A0A090ND73|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
GVSVKLRLPHCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRF
TVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A090NDA9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MEASPKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIK
QSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKE
NDTLHDAYKASDERLYVNKQNKNSRS
>A0A090NFG9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLAN
EAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSL
QSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKE
RLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLM
ENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKML
RQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAA
GDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIW
EGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQAAAHSERA
AMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQTFRRSYSD
PALSHALDPGYSTNFSSRPQKRLPVKA
>A0A117EDR7|diguanylate cyclase|EC 2.7.7.65|Streptomyces scabiei|TrEMBL
METDSEPYVRLTTLRQLHQVMADMNTARSLADTLQTVADGVVNGLGYELACVNLVRPDGD
LVVAALAGNSAAEALITGRVGSREAWDRRLSMGEAWGDLRFIPHTEGWVLDEDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYTPGASGASCGELLGVVSVDRPRNGRRPGAWGREALQMY
AFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHG
RILRTNDALCRLLGRPASAMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVW
VSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDALTGLPNSAELRSRLSSR
LCQRPQSLPAGAAADSMDAAFGQFGEQGDFGGGYGEFGEHGGAEHAARLPHPSFDDYEAA
GHHGHAFDFHRAGGAFDSFDHHVHTVAPEGERDDGTKGLAVLFCDLDGFKSINDRFGHNA
GDAVLIEVARRLSRGVRDGDTVARLGGDEFVVLADGLGRADAQDLAVRLRNEIIQPIRVD
GRAMRVGASFGIGWAHCGMTADEVLKSADERMYVEKRSRPRQHRRAG
>A0A5I8HRZ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ouakam|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A518CZQ8|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla163|TrEMBL
MDTRPLILACDHRDGTLARKLAAPERGSVRPGPPLTDARIEVSASLRESLERLRRERPEV
LVIDPLTPGGLAELGALASSGGDQLPVLLVGEHGDASVLVNRVEGSVPWDLIDRRAHPGE
FRLRLERLLRDARLRREVGELRHRASHDDRTDLLRPQAFQDLLQGQFSAALEVGASLALI
MVDLDDFGSINKRYDHTVGDAVIERVGAAVRRTLRLEDFAGRLGGDEFAVLLPYAGAPEA
TRVSERLKDGIVRLSGRWPEFGADLTLSGSFGWAVFDGLQPPSVGDLRLAAERALREAKR
RGGNQAVGAHELVVHTSNGSPAPE
>A0A857JPM3|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MQDNVMSKAIAFKWLRGITFMVLWLTVWAVAQLMEYTAHASVWFPASGLTYAALLIIGSS
AVLPLTFCAVIVTLLTCIQYTLPLNLPQAIQAGILFAGAHIIPYWLSALLFVWIAKLDRL
STPGMIILYIIHSGVASLCTTVLVIYSLVFSNMMPASDISQAWLAFWIGDYAGVLILAPL
FAALLSQHFEKKHFILTKYLSPNQTKASPFYFCKIMLVTLLVSFIMLLNQYTQQQESAFV
IFLLVLPHMWIACTESALFNMLSLTYSCLLIAIFVNLFGLNEYVLIYQFAIIIVAANALF
GIAVPALVADNEKLQAIITTDALTQAASRQHFMQQAERAVKRSLNDEIPLSLIMFDMDNF
KTVNDTFGHSAGDKALQSVCQVAQLSLRPTDLLGRFGGDEFVALLPDSTHLEAQQIAQRI
LTSVNQAEVAPGQPIQCSFGVAQLRQDQNFTELFNAADHALYKAKQQGRNTIVNAESLYA
QDLSTKNNNTDEENLV
>A0A6G7GPQ8|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MNAFMPICSKCFALTFDKEEIYGAITRINCMGLRCKPEAAKAHYLKTDTTMKILIANYSE
DDLRFLERMLEKHGGEVTSATNGLTAFETLQNNRFDLIICDILMPHMDGFQFCRKCKTNK
YLRNIPFIFYTTAFTGRRAREYAMSLGADRLLVKPMPADIFIDAVMSTLNGYKKYLPHPI
SAFSGKDETEFCRNYNEYLIRKLERQLLDSEGENIGLEENELKFANLASVINDGIVVLNE
NGHVTHWNPAAEKIFGYSEEEMKGKNILNVIGGAEHTEPEMRFFNNIKAGCIINETIEIT
GVKKNKSEFPLEASFSTLQIGRQIHIIAIFRDISERRKKDDEKRKKQAILQLINEVFDTA
HDLLTVDSTMRLYLKKMCRYLGWPVGHICKVIYTVNGAIRLESTRLWYFENTKEFSLLRK
IGENTILKPGEDLPGKVFSSRKMEWIPDVTKDSNCIRAQHAIVKSAAIGVRGAFAFPIKE
GDKILYIFEFFSRKEEKPQAIFFEVVDNLALQLGRLIERKRADERIRKLSQVVEQSPASI
LITDKEGIIEYVNPKLAELTGYTGDEIIGRTPRMLKSGKTSNETYRNLWNTIISGKEWQG
ELLNKKKTGELYWEHVHISPIRNHKGHVTNYLAIKEDITEHKKFETQLLNMATRDPLTNL
FNRRRFQEELQYWIAQTLRYGATGALLFLDLDNFKYVNDTLGHQAGDELLIRLAEMLRSR
LRDTDIFARFGGDEFAILLPYTDREKAGLIANEILELTREHTFEHSKVTFSIGIVIFPEH
GRDAETLLVNADLAMYRAKESGRNRFCVFSQEQKTHIEAQINWEKRIRNALDNDRFVLHL
QPVIDLSNKNIIGYEALLRMLGEKDELIFPAEFLSIAERFGLIRDIDRWVVCSAIRLAAE
QQFSDRGIFLDINLSGKAFADTELLGIIKHQFNTSGTKPGSIVFEMTETAMMENMIAAQD
FLAALKHMDCRFSLDDFGSGFSSFNYLRHLTVDYLKIDGSFINDLPNNPVDQHMVKAIVE
LAHGLKKRTVAEFADSGDTLQLLRKLGVNYAQGNYIGKPRSVSEVFN
>A0A1V5GQR9|diguanylate cyclase|EC 2.7.7.65|candidate division BRC1 bacterium ADurb.BinA364|TrEMBL
MSAMRILLIESCPRRAERFRKLLRESGIAAEFSLAPSIDAAFELLDSREFDAALLGVDGL
EEKISAAILRYRRRGERPAILALTENAEEEIARKSVEAGAQDCLALGRIDGEGLARSLRL
AIKRHRKRLALEREVRRYRGIIQASPVGIHVYELAQTGRLVFKGANPSAESMLGRDRKGR
LGRPIQLAFPELASEEMREQFEAVAQHGENWHGEEIVYESDGRSVVLDMRVYRISPREIA
LAFLDVTKRKRAEMALRESEARIRTISDAALDGLAMTDSAGRVIFWNPAAQAMTGYAGAD
ILGRDINEILISAAEDGERECPLLRFLEARDGGSSGHREVSIQRKDGTEFTAEIALSSIR
AGRGYGSVILIRDITGRKSMEEELRRLATTDPLTGACNRRHFIKTAEEELSRARRYRRPC
SMLMLDIDHFKKINDTFGHDAGDRALKALTAACLAALRNTDHFGRLGGEEFAALLPETTG
RAALDVAERLRLALANIRVDSDSGTIQYTVSIGATELREGEDALEDMLKRADEALYEAKN
TGRNRVAVR
>A0A2X0QU84|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrotoga fabula|TrEMBL
MDLSYFNFLAGYILDDTSFTERYPWKIAIYRLYENSWYEGDKPVANSKIMSLLHKAWGCK
KDQKFQNIHITRLENLDAIIATIIPPRTRHTTISDFSKRLAMSISNAEHKYYAMHDKLTR
LYNRVGFEKEFQRKLAETNVLDSANRNSTSSRKYIALLILDIDHFKQLNDSYDHSFGDAV
LKAFAWRIKDFSAELETVENVGITLGRQGGEEFEILLTNLSGKAQAIKIAELFREKINSE
VIPSKSQLPAIVKELQLEHIKIPPERERHIRASIGCAVLLVNSRMDSVADQTYAELKRKA
DAALYRAKADGRDRVCNYDHILQKHGRVIRSFPEVSLVAIDLGEDVGAMPGDVFEVTPVE
FSGGYELTREDARSTRLLGIIPRIPTAKIVVVETQREVSFCRVIESTGNDPFPHNASLRK
IPCGINTPILDVAVPELESALCSYSAFEKGLNQLSDFTGLVFISIEPICGGVNCTERSAS
EVQRKHLHAFVHGLRIILPPKTIFGYVDYKTIVLKFHQLDADEKITRKYINQLASISIEN
HRVIIGALLKDTLENIVREGLSYSPEAILYYVRLAHFVAKKSATQNVEIFDITETCKQAI
YDLRLENRKSDMLLEYHRLSSYGFKNANLDNQIGIILLEMNDMTFLSVAEQAIESAIAID
DNEVAFKANLAIVKTKLAKYQDAYGLFVDARKFMDESGLYWLYSLAFAKAAMEQYKRDQT
VIKPDDLTKAIRRALADSSPSSVQEIEWYSEIEMFSKAIQDRG
>A0A7H4MND3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIAAPYIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A7H4SHY4|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MLKHVNHVAKRFIIYVFICLLAGFGIAGVTAFFHTSFSTTSSILFPLLTSFLMVFHITIA
CFMGMKYWSNKRRLYLTPVAFGFACSALLMLGTLSSYPDWLTCSTTPVINQNDAVIYYFF
RNIMMAVLFMSSIVLYYFRQRIMHSLKAHIITFAACIVFTLTIIFLSWVYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAIWFITLILLISLSKLRNIFWFSGAFFCSAYLYTLFQL
VSTAGDLDQTWYQARFFETLCTLFLILVLLVDVFMLYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNPQHPLSVIISDLDHFKRINDNYGHVAGDKVIQFAASVLENHSR
ADDAAARIGGEEFALLLVNTAEKDALAIAERIRLAVTLSNTLCRSE
>A0A1V5I8X0|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.BinA166|TrEMBL
MDGIFLGAIIGAAVALIAAVPVAISIHSRRMAEIRRKEALARAELGENIVRLNLLLGNSS
AATFIFRGTCFLALNRATEGLTGYSREELLAMRGLEHFHPDDRTAAVERSLARARGEPVP
SFYEIKLLTKDGETKWAEFIARDVIFDGQRCTVGSAYDVTERNRIKDELRLSEARYKFLT
ENMKDVVWTIDTETMRFVYVSPSVERLRGYTSDEVLAAPIEDSLAPEDSAKVSELIRAGH
RKLCEEEGALGAAFHTMELLQPRKDGSLVWTETIVSFQRNPISGRMELHGVTRDISERKE
AQARMAEMALHDALTGLPNRNLFSDRLALAIAASRREGARAALLFLDLDRFKPINDTYGH
AFGDLLLKQVAGRLTATVRGVDTVARIGGDEFLVLLPGEGDEGAAAAADRLVEAVGRPYL
VEGRDIRMSCSIGIAFHPDDALGEIELVKNADEAMYRAKQAGGGCWRMYGQPGS
>A0A379IU86|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MKRRSIGLLLPLILRESMVTTVILSMLCVHLLCFSVMFLLISRRLNGKTMGMEVFALGNL
LLGLAYILQLVDGPPDWGPMSLVNHTLTLAAPVAYVLGAMRFFDHPTPVLRPLLILVAVY
TGLQLLTQELFGSEARHALLAGACALLFLTMTVAALYGMRTFARDLHVEMIVFAVLIGGI
CALNAMKFVMIVNGGMAALDMSRGFQKIFYIYMSFLATVLPPCAVWLVLRRLTDELRSLA
AHDPLTRLLNRRGLMDALEAQFRLRAASPAYLLIVDIDHFKHINDTHGHKVGDLVLCHVA
DVLTSTARQGDLICRLGGEEFVVVALETDEAGARQLAERIRAAIELSAVPASGEKQAIRC
TATIGVADVFNAAQAFDLALQHADAALYRGKTAGRNRVEWAHAARE
>W9UZE3|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MMFYKNENALTAIVQLSRLELSSDYLNKKFNDHRLYTVAILLILIPLGLAEGVFDYKSHP
EIKSELLQLRLYFILLVIPAWIILKSSSLKLVTAIILVTLVFSAYLGIRIIEHTGEDLVT
TVSNVALYPFFIFFVLIGFSIYIQIFFLTVALSYVFLTENHGVLDELIQNAYFQISVQSS
VSTLFIMLVFSWSYYHRYNLQLALEKSSQTDPLTGVANRRHFDNLLKSATTRSARSGVEC
SLILLDIDHFKSINDTFGHPTGDRVICALADLCVKQSRATDLVARLGGEEFAIILPDTNI
TDAENLAERIRKHVEDISVAGDAGEIVKWTISLGISALPLNKSSANTTEIVMEMFIRQAD
SALYEAKNNGRNQTVLSQ
>A0A087A8X8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium callitrichos DSM 23973|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSAAATGEEGLELFTKGGIDFVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVMRRNQ
QAGGAADGSAAGDDVPLTCGDISMQVGQHQVTVRGENVFFPLKEFELLEYLLQNKGRVMT
RHQLIDRIWGSDYVGDTKTLDVHVKRVRAKIEEDPSHPKYLTTVRGLGYKIDQPVA
>A0A1V5HWD1|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.BinA166|TrEMBL
MNIGRMSIEGMLRYYRRVFVLALVAFMAVVSVFGYVQASRVTERDLSRALEMQSTALERW
FSINLNFVRSIANLPSVQALQYEAIFADFHRIAGTNINFRSISYVDRDGNPVVQSDSGVI
LSPGVNVSDRDYFREAAAGRPYITDVLTGRLLGKPIVVFSAPLSEGGRFRGLVAGAVLFD
TILHTIMSTKFSQTGRFLLLDLSGKPIKLQDGTTIHNGDFDLGRLDAESSVVCRDESGAK
FLVKAKKLARTNFILVARMDYGEFLTPILVTLGYLSTVGIMLGFILHLTTRRMFSVAERS
LTLLAEGVASFEHGSFDGLDTARLDEAPEEFRSLGLAFNTMAEKVRVKTEELEFKSFHDE
LTGLYNRAFFVDAMTRFASGRFDPITIAVCDVDGLKLVNDNLGHEAGDELLSAAARVLEG
SARKTDIVARIGGDEFAMILPGSSADSGDNLLQRIRDRLADYKADPGALPLSIACGSACS
CEEAMNMGAEDLFRVADDRMYAAKRSGKRAARKEIQAFLASGARQSLQAGHGALEPDLPS
RGDFDRSAFC
>W9UVM0|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MYPLQELFSAGSHTRYFQHTRSYYIFRRVRIIALLLAILQSAWILVDQWLLPANVQWPIA
IARMISSLFFLGIFFWQTRPYSRRLALLRLLLLFTGLTAFHAFSSALLLIHGYDQSVAGY
QFFPFMIISMMAIFPLVIIEVLGLTLLLTSAELVTQLTRGVLGDVNSINNVWLLLVLAIV
AAWATVNQLNMLLVLHRQATRDALTGLANRRLILEQLDSDMETCRENSLPLAVLLFDLDK
FKGFNDTYGHAAGDIVLKQFASILRKHTRKKLDLAGRFGGEEFLMILPGMDKEAAIQVAT
AIGESCRQTSVAVPSGEKVGFTTSIGIAVLKPHENQSDLIRRADEALYSAKDAGRDRYEV
A
>G8AR87|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MSARVLVVDDVLPNVKLLAAKLTREYFNVITASNGPEALEMVRRESPDIVLLDVMMPGMD
GFEVCEKIRSDPATMHIPVVMVTALSDGADRVRGLEAGADDFLTKPVNDVALFARVRSLV
RLKMMMDEWRLREATSGQLGVLEPTGTLNSESFEGARVLVLEDSRLDLDKVAETLRRDHA
HVMAADTCAAALERALGDDLDLVVISLTLMNEDGLRLCSQLRSHERTRQVPILLMVEEGD
LNRVAKGLELGANDYISKPIDRNELLARARTQIRRKRYQERLRANYEQSLSMALTDSLTG
VFNRRYINAHLPRLLERAIDNHKPVAILLFDIDHFKVVNDSYGHTVGDEVLKEVSSRASR
NLRTFDLVARLGGEEFVVVLPDTDAEAALTVAERLRGRIADTLFKVSADVGEIPVTVSIG
VTVGGRLGDTAEGLIRRADEALYEAKRAGRNCTIADPPAKALLSP
>A0A0K2G722|diguanylate cyclase|EC 2.7.7.65|Nitrospira moscoviensis|TrEMBL
MIKILLVEDNDVDAHLTQDILAEWSIEQFDVVHVTRLSEAFGRLGKERFDAVLLDLSLPD
GYGLPTLRQVQAANPTIPIIVLSGVSDQALALQAVQNGAQDYLVKGQGQPELLTRSIRYA
IERKRAEERLTYLAQYDQLTGLVNRTLFRDRLIQAMARSKRLQQPLGLMLLDLDRFKAVN
DTMGHDVGDHLLKAVAGRLQDCVREVDTVARMGGDEFTIILEGLSCEGDIAIVARRITES
LAQPFILKEHQASIGVSIGITVYPSDDHEIDVLLKHADAAMYRAKQQGGNSFQFHTPLHA
SGPSLSSTSS
>A0A7Z9E1D8|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MVNGRSSEKELQEEVKNLRYQLETAQETLRAIGNGEVDALVIAGSQGEQVYTLQGADSSY
RLLVEEMKEGAATITPDSTLLLYCNKRLAALVKTPLKKLMGTDFKDFILPADLMLFEALC
QKAHSGSGKGELTLIARDGTEIPVYLSISILNQQGVDVGCLIVTDLSEQKRDEEIISQER
LTRLLLEKAAESIIVCNHQGKIIRASEEAHRILGKNLLLSNFDDMIKLELLPKQNGSQPF
LKKQRHSTFSIVSVINGNPYQGQEVEFIREDGEKFNFLLSASPLSIPHNNLKGCVIILTN
ITEQKWAEAALKKINEDLEFKVSERTAELESLNSRLKEELLEQARTQQVLQDQAKLLDLA
NDGIIVVDLSNYITYCNQGAEKLYGYSKLEVLGKNLVEVLKTQFPKSLDKIKQELFEQGN
WEGELIQTNCQGNSMIIHSSWSLKKDVNGNPISILKINRDITKAKQAEQAIIDSGLRLAG
ILDMAQDAIISINEDQEITLFNQGAEKIFGYTANEILKQPFSLLISQELIQNQGQDNSEV
FPSNGLVKHIKEYAEVRGRRKDGSEFPAEVSISQLLLDKGKILTVFMRDISDRKQIEMAI
QKAQEDLESKVQERTIQLATSNDELIREIAERKLLENKLHQINEQLEQRVEQRTNELGKA
IEDLKQEAIERQKTTLALQESEARFRAAIDGSLDAFFLLQSYRNEAGKSTDFILVDMNAK
AEEMILQNKENLIGKGLCDVFPWGCELGYIDKYLRVFKTHKGFEEELAVSNPTVKAKWVQ
LQVVPLYDGIAVTCRDITERKQTEEAAQEVNEKLTHWVNDLEQRNRETLLLGQMSEFLQA
CNSTEEAYQVINELLKPFFPNLSGNLFVIKNSKNLVEMVASWGELSGVSESIFAPQDCWA
LRRGRRHFVASCESSLLCKHIPKKIHQHQLNLLNSSDIPINSLTETELSFISSPMVEHLC
VPMIAQGDALGLLCLASHKSGQLSEDQQRLATSVAEHIALALANLKLREALEYQSIRDSL
TGLYNRRYLEESLEREINRAQRQKFNLGVIMIDIDHFKHYNDTFGHEAGDIVLQQLGNVL
QKNIRGSDIACRYGGEEFTLILPEVSLEIVQERAENIRVEVQKLKLKHHDLDLGQITLSL
GIALFPSQGLTGESVVRAADSALYQAKQQGRNRVCVFSKTFENSA
>F5NTY1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISCLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5P9C2C1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MIQACVASGWSLSPPVLLTLLVCFGVVMLAHWVTRQRDFPGRDSFILLHLASLWWMGAAA
LEMSFLGADCKMFWASMAWPGIVATPTFWAVFLWQYVNSMRAPLPRKGILGLSVVPLLVW
GLALSNPWHGLFYGAGSAPIDDSLGAPVRYEHGPLFYAAAVYVYLFMAFCMGVVTRAAAL
SQGLHRRHYLAFVLVTAVPWVANVGYVGFGWTLFGFDPTPFSFAFTLVAFSWLIVGVRLF
DLLPVARHLLLEALLDPVLVVDPCRRVIEANPAALKLAGLQQGWQGRELKQWPVFGADLQ
ALLLEHAGEHDRPLTLTSAARYYEVRLRAIERATRHGPALLGHMIYVRDVTQRHLSELKL
AEALALSEERLRTISSLHEQLREQALCDPLTGLYNRRYLDEFFERELARVQRENLPLAVA
LIDLDHFKRLNDECGHLVGDDVLKAVAQHLLDNLRSTDAVFRIGGEEFLLILPGADPDEA
SARLQSICSQLAAREIATRGGDQRVTLSAGLAYWPQQGQALDELLHAADAALYQAKRTGR
NRVCSLDESARVSHPSR
>A0A8B3WJZ3|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLLVDSAEESDKQYGIENQGVTRSLAELTQIINALEYNITALYPLHGDTYVFSHEKKIED
ETCYFTSEEQHAPRFDFMFSGPREMCDPKSDLYTEAGKRLFIAPTMAYFANTIETISAIY
FISKEKFIISSPSDIAQYMKGDTFDSVVNSRPYWINTIRFGLAQGQDQVVYTGQYDDYLT
GKKVVTLTKGIYVNGEFKGVLGVDGYVSNLVSNPTHGYKVTSTRGANKYGFMDFTYSKPL
YVDDINTQLYLSIEEDKIEHFLHVLAMEKIQLSILLVLYLLSVLWLWRFYTRQEHQRLND
LAMRDPLTGLLNRRGFEARLLAQDEQPIIGVGVFDIDDFKVVNDQYGHKTGDEVICHVAQ
LMLNSVRQQDIVARFGGEEFVVAITGESSELLSSIFERIQNDISLQSYRCPTGDKVNISV
SGGATLYSLYKFDSVGHLWENQSIRSSDEQLYKAKAAGKNQVCIQVY
>A0A2G4B0B1|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MSDKAFRKLNIFLSIFCLAITLVSLISFNTRMNKSYVITPDKYPTRVNTDRDHDGGTVGS
LHKSEDGIELQCDFERTYSLPFCEIEFVISTQGKGLDLSTFDSVTINMDYQGQEDPRFRF
YIRNYNKNYSVKGDAMSNKFNRLDFSLPDKNHIDLNYFNVPFWWIDHYNQPITSSAVDIT
NAVSVELGLGASTLDGHHSLKISSIVFHGKIISKALLGELLIGLWVTYAICYVGCALHIA
QRSRTRAAEQQRNLTEEIEELKVKATTDPLTGCRNRTEALDTFYDFEWLAQQGKTIHIAL
FDLDHFKQINDQHGHEVGDKVLIQFVAIANESLGEQYLLYRWGGEEFLLVCLEQTALQCN
ESIDNFYLAMDQSPWPKALKVTASTGVTQLKEHESIRTAIKRADKALYQAKDNGRNQVVT
FY
>A0A2G4ATR6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MTHSVFIALLLFISFYSHGQVSTQDRHQDSPFNSSNLNSNTTPNADWNALYLSTLTHSPS
RALNMLQTRYIGSTVYGDKLYLSSLLYQYMSHRDQPFYGIASNDSEYQAIEQTFIYALMK
DGQGQYEEAQQSFLTLLAKMQSRSDLTGRALLKYQLCRSLNEQAKYHQANYYCSALQSDL
HNIADPVLPKFGTYRVIANNHHFRSDYQAALDTYLSLINVFPQGHDISGIYNDVGNLLKE
LKQYEKSAEYLKEALTLRESASDLMKAQVHHSLADLYLNQEQSDLAINHFQTARTLLSSS
SHSYGIALTSLGLGKAYTQIRDYDLARGYLVNSLSASNELSNDVIRINAYLAISDMFEEQ
KLTTEALNYAQQALEVSEQVTRHKYIAQSLLQLSDLYQALSDYQQAFYFYQRYSSIQIET
RDIDNRLAFEALDLTHAKYEQELENSFLINQTKLDRVQIEKMEHQRWLYNVIVILLLCAA
SFTVLANQTIRAKASIDAMTKAYGRTEIIRRIKRVRRCKGTDKQHVLVLLDLDKFKTIND
EHGHPTGDRALVHISQQIRKHLMSDELFGRLGGEEFLIMLTDTKPSEVRERVEELHYAIS
STVFLSESKKPLNVTASFAYLATSNALSDFDDLYSVLDQALYQAKSNGRNCIIDAYNEPI
D
>A0A143QJ82|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MLAVFAAVTTVLYIANGIASWSDLSGPQQLFAALAVVLGPAAIVVLARAGAPSPKHAVGT
ATALSVGALACALGSSNTMPAFLICVQAAMFLGMHIGAFWSERDAGIWVAVLAVSAVVGA
AVAPYGTPFISYILVALGIVGATEVFGVFARRMRYSATHDALTGLLNRFGFESKIEKMLP
ACAARGLTVSLAVLDLDNFKEINDEYGHIAGDVLLTRVSKAWKGQLTKRDVLGRLGGDEF
VLFMPGVLEAEAWQVIDGLRRSHRAEWSVGLACMPAGRRWGEIYRAADADLYRAKRSRPP
KASRHTEPGDGHRGPVRRIV
>A0A550ADM4|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MNETYRHKRVTESDTTLNAILDLIVEGTWDWNGETGHVTRSPGWYRMLGHEIGVFQENVF
TWENIIHPDDYKRVMAHFEQYISGQSPQYLIEYRCKKSDGSYLWIVDRAKILAYKTDGTV
ARMIGAHHNIHDKKLAEDEVKKLNKLLQQGNMSLENLTKIKAKKLQEKNQELETKIKEVD
LLSNIDPLTSIANRRSFEKELSKELLRSRRYNHPLSLAIFDIDLFKNVNDTYGHQIGDVI
LQKLCKLISDNIRELDFFARWGGEEFVLIFPELAIKKALIATDKLRKIISQFEIAPNLYI
TCSFGVTECTDNDSIEDLFQRIDNSLYQAKSNGRNRVESR
>A0A174V7I2|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEDKYQVEIKKKLAESVNRAWKIISVFVMAFQFLMLILMAVKPGGPFKTHRRTVYCFLYL
VLLLVTGIAMILNQRFWKRENKNYHRYLNAEIVYAAFICFWGCCVTLNDQLGGNDLSVFT
YTMLSVAALGFLEPVKAVVIFMSAFVFLNLCLPGIQTIENNMFSNIINSFSIAGISTAIS
YTLYRNKVIVTKQEMTIRKQYEEITRVNEILSRQAMVDELTEMNNRRYMEWFIGEKIKIL
EEKTGTISCMMLDIDYFKQFNDRYGHISGDICLKKIAEMIRECCQDQNVAAIRYGGEEFF
ICLFQWDQDEAVEMAEKIRKRIAECRFKINDEEEGAVTISIGVYTWHGEGKVQMDDLIRL
SDKALYQAKKNGRNRVEVLS
>A0A202FAN7|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MLTKIFLDNAPLIASLFFIMGAFIVFQILFAGVRLILKVRRRNTDRYLLRSILGIIYILS
LLFIMQLSIRGKNQSWIYVNFQLVSIIFYTVILSVPFKYHLFGPIVVAFMAFNSALTSWE
SWCLAIVLIVFYYSLNYIKNHTKNKFPFLSYLIVSLISGFAYWFFVKVKFSISNPMFFRQ
VIYLFIIELFTFGYIAILYTDLESRAALFRDATHDKLTHAYNYDAFDIDFRSLFKDNVIS
DGKFTMMMFDIDHFKSINDTYGHLSWGQGFADSGRGCTDCTRKK
>A0A202FCS8|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MGNLMEILRICFSANALVTGIVTIGLVTIITYISFILERKVSTASSFFKKVGINIAEMLL
LLLMLLLVTIVFKSLTGGSQVELGGLLANAELTILFYGLFIFNNRLIILLNVFLPFLYHP
SSDISRIQGPYAWLFIVSYLILIIVIDYLYSHKEVLAISNYRYLSSQMLFGICWWIFIWI
DYRFPLVDIIGMLILFEFYMFVVRIIELKMSTYMHAYNDLENKVNYDALTGVRNRANLNK
VSKEFFEKYSQSSVPLTVMMFDIDRFKEFNDHYGHEIGDEVLRHVSHTVERELHVDGSQG
QLFRYGGEEFVILLKNVDTKRAQEIVNRINQTLIEMPLFIQGTQLDVTLCFGVTMLRKTD
ESFDEIFKRVDEYLYQSKNNGRDEMTIEGKIFQYEKVPMIKI
>A0A399DVS1|diguanylate cyclase|EC 2.7.7.65|Meiothermus taiwanensis|TrEMBL
MSEGRLPRRLRLPRAPAQAKTQRTPPVVPASLIERLLKGGLSSTLEQTLSELQDELPGVA
QALFWVRTGPNHFNLGAARGVAKAVLEELEEVPESFIRSAYLGPPEGWLGGVAQLDGRPH
LLAQLFGIQPAEAALEVQEAPANLTLPLAVEQKVWAVLHLHATAQQLDAAGVGWVGRFVS
SIAPILHEVYVREQAERQSLWLSAINALLQTSRDQPLEVVLQDALEEATRLSGADGARLI
AFEGSVIRTIAQAGWGAGLPLEAAVARPMGQRLRSGQQVSILRYDLYPGQRPELVEAGLR
SLFILPIQHQNGETDVLLLLSTRPRWSPKAQTQVLLGDMAAAIEAVRTEWILRRELTWAA
HTDPLTGLGNRRAFERDLEQLTSRSDGQKVVLVLFDLDDFKRINDTYGHVHADHLLERLG
GVLRFKSRAGDRAYRLSGDEFALLIGGSSSIDPGRVVERYRALLEGIRVAGQVYLKVSLG
YATFPTEASEIESLWRLADDRMYKDKARRKGRTPLFAPSDDPIQWRLQLETPLLRLAARL
AQVLQMAPEEQQVLQASCYLLELALGRVKPSQDVPIPESLLLEAARVLMRLQTSWEEARQ
SQNLLREPAPLVLHVLQVAQHYITATQAVEGRAARSVEEALEEIAALAHRRFAPAVVEAL
YSLRVWLNSE
>A0A649YKW6|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MLDKQREAWLSLILNELPDRLFVLEQSGRFVEGFGGTFHSVRLEKNGYANKTLHDILPQD
KADQLLSYIQDVSESAKPLVVQYSVNPIECLQLSIDELETLDGPEDMWFEATIKPLCLVD
GTQYVLWQERDITSNYRRQEELKRLSETDELTGIFNRRAFLEALEQELQSYNETQRNLSC
LMIDIDHFKEINDQVGHLSGDEVITQVARICQKQIRGSDYIGRLGGEEFGIVLSNTNAIQ
AYDIAERIRQSIESSPCSVDDHIIHPTVSIGIAEVTSGISHVKELLVQADKAMYYSKQTG
RNQVTLYHDNLPDMKVQSAIQAKIRQAS
>A0A5E4X234|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MTIPRPPIPPPPGAPMSGHAPLAGLAPVEMPGGASADSQGASTAHANGATHDMPLSGGTD
AAAAAANAFDAPVKHRRRPSLQGVLRRTHLRLAVSAVVLAAVSLTLVAWIALRVYAENNL
LLLGRSLAYTVEAAVVFGDRVAAQEAIAMIANEEDVVQVRVLDAHGAQFALWRRPDGGAL
ATLERAVADVALPGPVTLPIRHDGDVVGHIEVQGQGHQFFVFLLSGVGGVLACLLVTFAV
ATVLAKRMHRDIVKPLRALAEVAHAVRRERAFHQRVAATPLAELKELGDDFNALLDEFEG
WQNHLRAQNATLAHQANHDPLTGLPNRAYFETRLAQALSDAHELGTHVALLYLDSDRFKD
INDHLGHDAGDAVLIAIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRLAQSLL
VSMEKPIALPGGGEIVTSMSIGVALYPTHAPDAPALLRMADAAMYQAKRAGVGTWHVAET
PKG
>A0A0E7UKX3|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis|TrEMBL
MLAPVTLLVISTLSSLVTQGVLGSLLRSGIAGIRELMWANVLVLCSLLLFTLQANPAMPP
WLAIQAPNVLISSGVVLFCAGVFRFMQQRPPWRLLLLGLALSIGANIWFHYVDPSVNARV
VTASGLHALLWGGSAWTIYRNMPLRRSRYSYWFAGVTATVAALGHALRTAVYGLQIEQTQ
GLLQSSVWNVAFLAIGVLVMPSMTLGMIMMIHDRMLAEREREANQDFLTGLLSRKAWWRE
GERLCARALRTGRPLTLLALDIDRFKQVNDQHGHAAGDVVLRHFGSLATALLRSGDVIGR
LGGEEFVALLPDTDGDTGVSVAERLLASVRATPCSHGGKALTYTFSGGVAQYRAGDTLPV
LVERADAALYAAKQAGRDRIRNRAG
>A0A649YYU0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MPQISDLFKFGPFELHQRLDALSLSYGDSQAWQSSLTTESREEIKTAVYTQLLQHFEHSD
VVSQILGHFHIHQSLDAYLDTLLTQELEEGYIEELAQHILGIAKYEEVHEYYSIVSHVLH
RCIIDNLASRCRSLENFRSLELRLQLDLSILLQFLHTKSMEDSRRYAALMEVKDPLTDLY
NHNTFPNELEKMLARCKRHKTSVLVLDIHLEGLGAINRRLGYEAGDTLLQNFAFIAQELI
RQSDLIARGTRGNFYFVLEDTTNRDGKAICERLISAVDGSSELPITLQIGGASYSSDSDI
DGDELLGLVHEHMELARARSLINHRHEYSVHFDSKDNLIQLIKG
>A0A649YYL3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MSGYKYGSCYYGKIEDVDWERWQKLVDMIALLFDAPAAFVTQATTNGIEVLVASEQAPSQ
YCPGAYSDKNTNVYCHQVVQSNQMMYVADASEDEKWSDNPEYTEDQFSSYLGYPIQWPDG
NSFGTLCVMDQRPTDYSDKLMTVLSFLRDTINSDLAYLYKANQLKVESRFDELTKALNRR
GFTESFERHISLSNSFNRSSMLMYLDIDGFKAINDQWGHSVGDQILKDFATALLKSVRKS
DLVARWGGDEFVVLLDSEQEVDKSRFVERLDESLKTSCQEHIPQYSIGSVELASGTDPSK
LTDFLCKADAAMYDNKSLNKTKR
>A0A5V9GQ00|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Wandsworth|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4Z0IBY4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E5028|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHQAMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>I6CFS4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFNLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>I6D5X7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MFLPIASTLVSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGM
WVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAP
LEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNE
FDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGD
EFAVIMSGTPAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKS
ADLALYKAKKAGRNRTEVAA
>G7Z7P9|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MNTNIDRYLLAEKAGSEGVWDWDLRSDTLYLSPRFKDFLGLPPGDPSRETNRPNDWLSLV
HPEDIDWLHASFEAQMVGLSVPFQIEHRVRRADSVSAASDKAQWRWLVCRGMAVMDDLGY
PIRLVGSVADITDRKLAEQRLRQSEERYALAAAGAADGLWDWHIDSGEVYYSPRWKAMLG
YGDAEIGDTVDEWFQHVLPGDLDGLRSAIDLHLTGERPHLQHEFRIRDKAGAELWMLVRG
LAVRDDRGCAVRMAGSMTDITARKKAEQQILFDAVHDAMTGLPNRTLLLDRIGQALDRNR
RVGARPFAAIIIDLDRFKAINDALGTSAGDRVLRIVAQRLDISRRVGDTLARLSADEFAV
LVDELDDAGDALEAAERMARAISRPITLEEGGDLVLTASIGVALSQTGYDRAEDMLRDAS
LSMYRAKSGGRARIDVFDANLRRQAMAAMRMEADLRAALEQGQLCLHYQPIVLLETGAIA
GFEALMRWNHPDRGLVPPAEFIPLAEETGLIAPMGRWALGEAVRQLALWQARFPRPAPLF
MSVNVSTRQFRDDDLVGAVRDLLDAVPIPPSSLKLELTESLLMQDPDECRMLMQSIRDMD
VRLSIDDFGTGYSSLAYLHKLPVDVLKIDRSFVRAVSTGEGNAAIVQVIAGLATILRLDA
VAEGVETADEAVYLRGLCKYAQGYHFARPAPPDAVERLLAAEDAHIALPAPA
>A0A4P6LZ55|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MREKGIRKIQHWILIIAAVIMSVLMVLTALQEKPQKDWGKESSLYKWDTGWYCDAGDGWK
EICKVPSRIKSNSGAVVLRQNIPEFLEEEKYLGFLNHYQQAEVYIDGERRYQYLEEETGS
FCSMLGNTLCMVKLNREDAGKELTLRISNFYKAGQVQIPVIYLDSQESMFMHVQVQEQPR
LIFCVVLLVLSAGLFLLWLLLRVGEAVRVSSVFYAWIFILVSALWILTDSQFMMFWVPWP
RLICFISFSAFYMIPIPMLSFIKEVCNRRSVMLDWMKAVLSCNVLVQSLLYLTGVCKLMN
MLPVTHVFYAAAIVCSVIYMAMELKSSRAGYAKIFLAGVFFLMLMAVVSLFSFYTGVGSR
YAMYYQLGLLGFMCALICMTMRQVNEILEDRTGDRILKELAYMDIMTKLGNRSAYEMRLQ
DLQRTMVQGQELSAVMADLNGLKKINDTLGHRAGDEMIKGCAWCLREAFGGFGEIYRIGG
DEFLVFVKRLQSIRTWEENLKKAQERYNQEHEVKISIAAGSATGRMSGESHDWLQELIEQ
ADKKMYENKKSARE
>A0A7U9WUR9|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MGYAEIPYDRRIKENIRNYTLINLYDMDIIKKYLNNLAEILELNLLLTDRHGEKEIVVGD
SFVGFHPDVVNEPGRKLRVQNYTIGHLYVKQLSESRDKALINEMVDGTMKLLDRLGEEAY
LHRESSIYLEELEKQLEDKKHKITQNEREDILTGVFNKIFFENRMKAIDRSEVVPVAVIN
VNINDWKFANDHFGDDESDRLIKIVADILKEEAKQYFILGRVDGDAFGVLIPMAEDGEAE
NYAARIQERCNTYEDPVLAPSVAAGIVYKTNIEETLEERLSDAEYEMFNNKFEVKNAPGY
KERLTRGIHN
>A0A8F8DCS9|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1V5JNQ0|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin520|TrEMBL
MAQSSRDHTFPEVPVLTPHRESRLFTFTKTLLPPSPDDPSDHLLAIVQDVTERHRAEEAL
RFASFHDALTGLHNRGYFEEEMRRLATGRFNPVGVLVCDVDGLRIVNNVAGHAAGDALIR
GAAEVLRRTFRSSDVVARIGGDEFAVLLPQCPAPVAQSRCRDLAHHIEEWNAGSPLYLGL
SLGLAHHQEGGKPSMERLFREADQAMYRHKEARREEVMEKIFARIASLLGEGEDDPVARR
QWEDLRSRWDPQVAHKKTPPTLSGDGGAAPGRHATDQSP
>A0A245ZGR7|diguanylate cyclase|EC 2.7.7.65|Sphingomonas mucosissima|TrEMBL
MPKRTTRVNARVGRGTESMAEFPRQKDDELYKAVGQFLSDQKLSVEPANYAFAYRVLSDP
AGPLARSVAALTDGGVRLTAHDIAELGGPEAASGAPQPCLDEGLAEPHTARVAAEAEAMI
ARAEMQVADFSRAVRSIHEETSGFGRDLAASAAAMRMAAPVAGLDEVVRLTAAMIDRAHA
AERRMAAAEQEAEALRSALDEAHGTARRDPLTELANRRAFDEAYAGLPPGTPIALALCDI
DHFKRVNDEFGHAVGDRVLRAVGATIAGECASAVVARYGGEEFALLFVGVDSDAAIALVD
RARSAVAARRFRSRATDAPIGVVTISGGVAAGTSDEPREALYARADAALYRAKAAGRNCA
FCAA
>A0A7I6TXX5|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-ESBL-04|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLIDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKIAAPDGSDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A7W4VFU7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus alkaliphilus|TrEMBL
MRPRLTTLFDRLWEQAVRTPQRFVVLSFAVAAILLVLFFVHGVGLLRDHQIQSLHQDQQL
QVAGISSVLNIEAERLMGMRGYAQHLIRLQSGPHAIAPDPPLKAAYDHRNDAVWTLPAPE
GDAVLLGVGPAALAGLDGFSRRDADLLAGLYVARGLSHLISAEPVNPLVARKLTYVSTNG
FFVAYPPVPPADAAATLRRIAAAGYLRQHLPEANPGQSMRWHFAPAADGAPDGYLSLSVP
VYLARQFRGVAIMEISQRSLDAYLTRTTRQDVQRFLVDADGNLVGTSTGDVRRGETLSEV
LPASWREATAQEMFRRGSGTLRAADGSRILFQRIGNSSLALVDYFSGTDLLLRTASHLSA
VLAASALALALLMWVTLQGIGKLFSHYQARGDALRELAATDALTGLANRRGLEARFAIEY
QHSRRDQAPMSMLMIDIDRFKRINDHWGHASGDRVLAALAGVMRATVRAIDVPARVGGEE
FAVLLPRTALEEAARIAERLRKTIGQTACAPAADAADQEEIRFTVSIGVADMGVDGTDGL
DAMMQVADRRLYAAKAAGRNRVVSDDRVSEPAAAQEAPVVASHIGN
>A0A411Z916|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MTRKIQKSEFRLKKTNDKLNEKIEKVEYLANHDMLTDMFNRRRIFEQLNTEAERFLRTGD
TFCILIADIDLFKKINDSYGHLNGDLVLQRFAVTLKENIRPYDFVGRFGGEEFIVIFPNT
KTETALSVANRLLQAVIKSPINIEGYTSLSISFSGGIAQMTHNMTIEKLIEIADNRLYYA
KKHGRQQIIVNDIS
>A0A411ZA11|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MKDCANCGGKNTAMSKTMSTRSASLWGAPLAMVTLALLSVALVYNATQSALWSMAAAAVT
GALYLAGLRHLAASHGAQNEPISDFDGLSDLPNRRALHRDFSDANSKGEEIAMALIDLDS
FKQVNDHYGHFVGDELIRACAQIIKTTCGGEAKCYRLGGDEFAILMSGVASGTIVEGICR
KVITTLEKPVEIGKREVVVGASIGLARSSATEQFSSSELLRRSDVAMYASKRAGKMRCTW
FSEGLDRNREAILEMDDELRKALVNEEFVVHYQPLVDAETREIVAVESLIRWQRSDGQAI
GPHIFIPVAEESGFINAIGLWVLRRACTDALQWDGLMLSVNISAAQLRNPEFPVQLGHIL
EETGYPADRLELEITETCLVLDPVVAERNLDVIRGFGVNVSLDDFGTGYASIGFLRQFRF
EKLKLDRSLVVDAETDEGSRAMMLSSITVARALKMGVTAEGVETQEQADLVRTAGCDQIQ
GWLYYKAMPADEISQYLPTKDDAEFHLEAAQTRGAA
>A0A7U9QZJ3|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKIPEYISKSPSDMVYCSAAINREYMVLMGDEHFYRFMGKTVGISMLDCVHPELRQEFQQ
ACGSLEQGGSARILTAMRGMDEGYRQIDMTIRDCGHTVNGEPVWELTIYNLFIIEEKYLQ
ASDDASRYRAFLSMYQDYLFNYDVEQDSFAVFRYMGIKSTVLMKCSLEELKESVTAMYPR
KSFQEELEVFCRHLLSAQENFSCDLRGPMPRHPMLMSLFHIDGKVIYKHNNQRVVLGILR
RMDQREEDASPYYATAEGKDSFTGLLNKRACAEYVAEALAAGGEPHYMAMIDIDNFKNIN
DTHGHMYGDQVIGQVASILNSTINGRGIVGRFGGDEFFLFTNWISSEIQLRAMLTSLRKQ
VQSTFENREKGCKVTLSIGVSRAPEDGRSYEELFKKADKCLYLAKYKGKNRFVIYEADKH
GDLVEEEQSIRHTMDPLEKAEYLADVVADIGIRLSAEGAEPMEEILDQIRSAFELDGVRI
HRAGRREPLYISGDYQPVPDMGSFIVENGMAGIMDHPHYLMASHITNLEGVNRELFETLR
NSRIEGMVCFCYPDREGVNLYFFFETFNHRFRWSESDKNFLLTASRLMANIL
>K1L086|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MGSQLTMYITLVCTSGVLNLYLCLYAFSKRHKYTNIANYFIFYTAAISIYCFASAMTLIS
TTLEQISFWNTILYIGMPTSATLGLLYVMSYLGFKLSFRRSMLILLIPFITIIMVATNHW
HHLHYRVFELDPNLGAPFVYQEIGIWYMVHGVYTFASMFVAFLLLLSHWKETGKAYRPQL
IALMFGQLVPTLTAFLYLNGLTPAGVDPVPMILWLSSLLYLWAINSSRLFRIMPIAKDTI
YNSINDGAIVLDESYRLIEFNQASKAMMPNLNKSMFGNNFVKFWKEQTGEALPFKLVTDG
IATQEIKLCSEGMERIYQVRITSLDQARNRKGLLLVFTDITEIKRLQEKLEQQAYNDELT
KIYNRRAFIQQCEQDFEAARETGLPFTVLLMDIDYFKRVNDTYGHHVGDQLLVHVVKVCQ
TQLQEGHFFARYGGEEFVIALKGYKEAEGITIADRLRGAVEKAPLMTEAGNLSATLSIGV
AEVKDWTEETLYKLLHKADTALYAAKEEGRNRVKVYVSSEGVVK
>A0A173KSY6|diguanylate cyclase|EC 2.7.7.65|Sphingobium sp. EP60837|TrEMBL
MGENYAFFLPVMMASFGVVFLIVWGWHVRAAGWWSAAFFCIAAGFSAPAGFAAIPTPLGS
IIADLLFATGFLLFSQALLQRWRPSWLLPVRLSIWGGSLLLCVIANIVDNLPLELVASDF
GCFLLIALPLIAAKGHLRGGADRALFAAACLVALDNLVRGSTVPLTLSAGSDFLTSNYAY
LMQALACIFGLFLALSALATQVIDLLGRYQREAMIDPLSGLFDRRGFDDAVARIEAEGGH
GGSLIVCDIDHFKAVNDEYGHALGDSVISALSQLIIAAAPPGAIAARFGGEEFVLFLPGT
NAARAAEVANDLRESFTRTVAVTLQLAHVLTASFGLSTVQRSDRSIHDAIARADEALYEA
KSRGRNRVCVRRALSSPAAEPVFPQRIVSA
>A0A7U9SB26|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MQYVGVVRKVKKGIVQVGFKPTRQMEAQARNTYDSIFTLFPADIGEEFFIIDNTTGTILG
HSGGLNQRFNEECYQLEQLRGCAQGAYRKGPQNQTMYLTSTSYENKLICAALPRKILFEK
LWEQISTTFLYLLFIEVVVLLLLNHLVRRKAVDGIHQIIENLTSITNGHLDTEVNVGGNR
EFQELSRRINTMVKSIVTSTDRISAIIEISGVPLAAFEYELGLNHVFQTSGLKELLAIPE
QMAERFFSNSVLFDRYIREIMTAPIPGETDIFHIRESRYVRIHISESSGKHLGVVMDVSS
DIQKKQQLHYENTHDSLTGLCKFPYFKQLASEILENMPKDQICAAVMLDLDYFKSINDTY
GHDVGDTYLQSFSAVMQSMPEEHFLTARRSGDEFCMMIFGCCSREEIISHLDRFYEALQN
HPAPLGPNQSKIISASCGFAQTSDSFSSIHQLLSQADEALYDIKRHTKGRYGEYGK
>A0A128FCI0|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MPDFKDILDIHPNPCVIHINFVPKYANNAFAKFSGMASAEDVLSLPSIRVLFEEEHWPEA
QRRYNHAIETGIPTPPEVINHMDLKGNPMIAEITDKVIDWYGEKAMCTFVSVVTDQIRRE
RTLRDMANRDDLTNLYNRRYLLDLFSERHAAQQRRQYLAMADIDHFKRINDTFGHPVGDI
VLRRFAQEIEDFTAPDEYAFRLGGEEFALLIWADNHTEATARLEQLRQSVQDCEVRVSHP
NSQPLTISCAISIGATVLDATEDFLSASLRADEALYIAKKTGRNRVINYDESAENAPEKS
>A0A098G4T0|diguanylate cyclase|EC 2.7.7.65|Legionella fallonii LLAP-10|TrEMBL
MIDQELKKKIVNTISQYELKCDKMQLQINAFKDVINQLIINSSGVNYEMDDHLTQLRNQL
DAEFDSDALEQKVQYLAQMPAKIQKKRIENTKTITKLIKQGTESISRLAKKSHDKRAISK
LQKMLNTEIESQAILVHFNEVLTQCVSSVIKDLEESAQVLKQNGAKETDWIEVGIKVNES
LQQLLNHLSIPHDLDAKREKIKSSLEQQLTSEGLSKIIDGLTELVVDAFNVEQNRFKGFL
QQLTNQLHDFNIFLKVTEDAHQQAFKDSRQLEHGIQDNINQIKNHFDNSKGIEELSIKVK
QNLDMIGDRIKEYRKNEHKREMEYQKQVMELQTKLSESEQNAEEIKNILSFQKYRINHDS
LTGLPNRDSYDEHIVDSFQRWKRSSNELSLAIGDLDRFKHINDNFGHLAGDKVLKKVATI
FKSSIRNSDFIARVGGEEFVFIFEKTSSKAAQAILEKLRKLIDECQFVYRDHKVDVTISF
GLTTIKKGDDIESLFMRADDALYKAKNTGRNRIEVL
>A0A657I4P3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Crewe|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DQVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A128EVE1|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MAKKIDCSVKQLHLLSFLKLCLLMLLVISTSYQLYNMAHTKQLIEKIDDDYRRLYTTIRR
FGPFYNNSQSVTMHNGVHNFGDISVVVREDETPVKNLSDGLDMLNNKLEQCAPESVWSIV
VLEVPSRYGVFYPLRPGYLESFSTYIPSERVNAMVERERLSNTYREFYGCITRMTEAYIE
SETQERIRTIYFPIHNDQALNAIIAVDIKESRTQDIINQYNADHHTVLNINGPNNIYSES
GELPCANDGPYQAGFHYLDILRTTFGPSILLAALFHLAFHSFRRRDRSIKRDEMTGLFRR
DYYEPKFNRMNSFAMLVMDIDHFKQINDEYGHQKGDEVIKTCARILATQIRAEDIAVRWG
GEEFVVMFKGIQHSALFDKAEQIRQAIASKEILGLSVTVSIGGYIAKNTTFSEAYKAADA
ALYQSKHRGRNKVTLA
>A0A723RYN6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agona|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1P8WJ81|diguanylate cyclase|EC 2.7.7.65|Fuerstiella marisgermanici|TrEMBL
MLKSTKKLSRLPTLPTIAMEILRVFGDPDAPIQRISELVQTDPALASKILKAANSSRFGL
PREVADVRQAITLMGKAKITPLVLGFSLVSESVADGEQGELFKKFWLRSFVRATAAEVLG
SVHGAAIAAECFTLNLLAGIGQLGMMKQAPEDYIECMKRVQAGDVSISEAERSAFGLTHL
ELSSKMLTDSGMPKRFVEAIQALAEPEKSNNLTVESSRLYEILTTAAAFARYLCDHDRGV
ALVVLKEQLDNRAADSNSMDELTTAVRTKLQNSAALFDIDTSVIPEPEALLNEALEQLSE
FTETMNDASEPSIPAELVAENGWLKQQVQSLVIQTSTDALTGVANRSYFDRRLDEMNKHC
LRSGIIYGVAVVDIDHFKEVNDTYGHQAGDEVLKCVADCLRNATRSNETLARYGGEEFVV
LLDNIPEQGMYICGERLRTAVEAMKFEFNGTPIPITVSIGLANGLPSGESFGETLFGLAD
AALYQAKQSGRNCVVVDYFSQSGGRPTRNSTCALRSAATISDDEVVPTYSYSSPSIELEP
>A0A128FBJ5|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MLENVKITRKLPLVIISFALLSSISTGMMSYKFAAEQLILSAESKLVALLDSRKESLLQY
FDTVKRDLFIHARSPQTRDAVIEISEAWADLGSHQQSTLQSLYITDNPFDVGQKEALLNA
EDGSAYSQAHKEYHPFFRNLAAEHGYFDIFLVDKTGNILYTVKKEDDFATNLLHGKWKDT
HLARAFTMVNKNPSVGNAYLTDFERYEPSFNQPEAFFATPIHKNGEEYIGVLIFEMPIKY
INSVMQISAGMGETGETILIGPDELMRSNSRFLDGENILEASVHTESAVKALSGVSGVQF
EQDYRGMEVLSAFAPFDFMSLHWAIIAEIERDEILSPLRVFVSALAFSVLAGTVVIFIVG
YFLASDIAKPIAAMSSMMNRIANNELDINISVSERKDEVGHMAKALEIFKSNAIEKDKLQ
KELTYMAHHDMLTGLPTRQLITDRLQAMTKSYSKEHFPFAVMFADLDNFKTVNDTLGHHI
GDEVLKAAARIFQEALREDDFVARIGGDEFVLLFTNLREAEEAMEIAEKLVVSIETGLKL
VSSTIPVTLSLGIAVCPDDAEDTTSLIRHADEAMYRAKQKSKNCCSR
>A0A2L0I5W0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ACNIH1|TrEMBL
MNNECMAMLAEQWKQICQNYSSDDLLHAFQFIQDHSSVLVEEFYKNMLLEEEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
MFELLSLNPQPNMLTTCSYIVQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDTLNQAVLKCTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDSDERRALNIAENIRKYVEHGLINTVQGQQFRLTVSIGCAL
FDGHPDYQRFLDAADAALYMAKNTGRNRVYLAQPSQIQGAQKASV
>A0A174TF14|diguanylate cyclase|EC 2.7.7.65|Dorea longicatena|TrEMBL
MKRLKQYSFWEYMRVLLVFIAGLAVSLLVFSYNVQVRTEQNVEELLDYNIDHQQSQLKFM
LNTQFIYLGNIADYVAKEDSLMCEKNQELLSCMTQDTLFHAISIIDTDGNGVTNDGKEQK
VADRDYFKRTMKGEEVLSDPLYSSLDGKRRVVLSVPIKKNGEIIGAVAGSFDMVKLSQIL
FEDVYQGKGYPMITTWEGKIIAVESDEIKDLQDENLFEIYQGKFGRNRERLESARQDFKF
HRKNCIKVKYKKQAYYIAYESLGYNQWMLCYTVPVSVASEEYSFITVYEYRLLGAVIVGV
LIMLLVLWKLNQKKQTDLINRAQMDSMTNILNKSSIQYQINDWLQHGEKEGIQALLMLDL
DQFKNINDTYGHALGDEVIKAAAKVLKDTFRSSDIVGRAGGDEFMVLMKNVRWDKVIERQ
MLELCRKFENLKIESIPCGAIHCSIGAAYYPDHGMNFDELYHYADEALYEAKRQGRNTYV
IYHQEKENLNH
>A0A378JYK6|diguanylate cyclase|EC 2.7.7.65|Legionella moravica|TrEMBL
MVISIVMILFGIVFLSRGAYLIKAVLQQTSYYRPQWHAYLAFIAFFIASYLATIIYGVLV
DPHCLNYFYATIFLVGGLYVYLSCHLTTKTIRKIELMDTLKMSYEKLHYHANHDSLTGCN
NRESLFEILKNRFQQIKLDGGQLIVMFIDMDGFKAVNDHYGHDVGDTTLQYFGQLLRQRL
RKDDIVARYGGDEFVIVMEQISSEDAQKIAEDIVRTTQQSINEETLPPLKLGCSIGITQM
NNQSTSFNAVIKEADRACYAAKQRKINGSVCMYSQVLSSEKEHNE
>A0A8F9H7R7|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377NA77|diguanylate cyclase|EC 2.7.7.65|Ewingella americana|TrEMBL
MPDFTSLGKLYADVCVTYATLSVSYFILSRSEPFTSNGDIWKRIAFGLIAGVAALFLSQD
RLMLNDNVYYSFEMLPMILVTFFGGWLSGLSCYVLLFVLKGGYSINNLLIGCIMLGLFLF
RVWRQRRHRVFYITLLLVGLARIALVSSLYGMVVPWATLVLYQLLAAGCMILCYHALNFK
EIYMKKVFAIRVKAATDPLTQISNRASLDYRLSIQQTHRQSCGLIIIDIDNFKRVNDTHG
HLIGDRVLSDVGRVLRNVTRSKDFAGRYGGEEFLVITGAYQPEAVMAIAERLRQEIEQSQ
MILEDGSELKVTASVGVSLYLPGCRSAKR
>A0A3N5D1B9|diguanylate cyclase|EC 2.7.7.65|Buttiauxella warmboldiae|TrEMBL
MIAVSGRVSVFGKAIQRVISRLKSPKKVVNLCFIFVFFCSTLLTWREAVVLEGAYVAGQR
NSLDNVATLLDRQLQHNIDNLLFYRNAMLYALQSPISTDRTRKSLADFDIFRSQPFWQLR
LDLNRSLPLSGVSDEFVASGPLLDRDEKTIHTELGSALELSYIMRLSDRSRTLPQRVFYA
SRSGFFLTSTPPPNDSKIVSLYQRLVVQPYFSSQAPQNNPNRSLKWTHTFEAGRSAGQLV
TAAVPLDYNGRWYGVLALDYPVESLHGFLQHAKYDDHAGTVLLYDNELNPIASSVEILPK
QPLFTAPELAQIASVVTAAKQGDRGELRMDSRFITWAKLNNYDGLLVKVHTLEEGVQGEF
GRISIVLSVLWMLFTLMLFVSWVVIRRLVNNMFSLQQTLTWRANYDTLTRLYNRGAFFEL
ARKLSQRCQQQSQPFSVIQMDLDLFKSINDRFGHSSGDKVLTHASMLLSGALRKSDIAGR
VGGEEFCIVLPDTTLEEATKVAERIRVCINSQELLLKPGKMVQISASFGVSSAFEFNDYD
FERLQIYADHRLYNAKLNGRNQVCNHD
>A0A6N3R392|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNHDYLLSTAHNAIDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>K9NHT5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MATPADAPNSAINEQGSRAKLSRPLPINLRGLILFFVLLSVLATLCNSLYVAYRVQRQSL
IHTTLEANAAYAAKVASSIGEFLNSAHSRLNYSANTLGRHWNDPEVLRKEAIRLQAQDAD
FNSIAIVDATGKVLQAYPDTSQIVGATLTSEGIQQALKERRPSVSAAYVSAAGNLVVFIS
QPVFNPSGAFLGVVGGSVYLLKQSTFHTIISRHFHHEGTFAFIADGNRRLLYHPDQKRIG
EVLGWSLTVDAALRGERGSLEGPNYKGVPMLAGFAQVPDANWAVVAQQPRDLSLAPLGQL
MRDMVLGMIPAGLLGLGLILLGTTLIARPLRQLSAAADQLAAPQTTEQLRQVHAWYRDAS
AIRQAMLTGVQLLQQKLGQLSHEAQSDPLTGLANRRAMGGVLDLLAKTGQAYSVLALDID
HFKKVNDTFGHDAGDVALKEVAGILKQNSRTGDLACRSGGEEFALILPDTPLDTARVIAE
RIREHIAQTEVPQVGKLTMSIGVACRNADTPIPESVLKLADERLYLAKQSGRNRVMA
>A0A0S4RJE2|diguanylate cyclase|EC 2.7.7.65|Campylobacter fetus subsp. fetus|TrEMBL
MQKIETITSNKIYREFIIIYVLISFVFSIIYLYYGITFLAFNKIVTFMISNFIYIALHNP
KYSKLINIWMQFGVAYNISCDIIVFGWGYGFELYFIGFVVVYYFYIFRNQKLEIIFITIQ
CLLYLFLYFMTRDKQMIYGDADFKEAIYILNFIIISCSLLYLHKNLNIVQAIKIINLEKN
KNNYQKIAKHDFLTGLYNRIPIQEIINQNLTLLKNHKLKSMCIILCDLDNFKTINDTFGH
IFGDNILKSVSSSLKNSFSKYGELGRWGGEEFLISIKDIDETYLKEIIDLARIKIENLKP
NELNVTATFGALYITDIKPDMNLEMLIYNVDQLMYQGKTEGKNRLVFKHYESEQ
>K9NK55|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MGHPLINDQIQMLRSAVPRLKVRSAVTLLMAVCLSMVAIVIWEAWSSRQYHLHDKEVVMS
NLAQTLASQAQATIKQADTLLFTLVDRLEHDGVDQSRLPALLNAQRSELSQLHGLFVFDE
KGQWLANSNGAGQTGVNNSDREYFIFHRDNPSRGPHIGPSIKSRSSGEWILTVSRRLNHP
DGSFAGVALATIYLTYFLQLYDSIDMGSNGVITLIADNASIVIRRPFKESDIGSSLAKSP
LFTRLLPKGDAGTATITSVVDGVERVTGYRRVEGYPLIVFAALNKDEVLASWRKETLLSA
GIVTLLLSVLGVLGFRLIKLMKQQNLAQVELLDTQDKLLEVNRNLEGLALKDALTGLANR
RQLDAFIDAEMGRARRSQSELALLMIDVDHFKPFNDRYGHLAGDECLRKVGAIITDNIKR
PGDLAARYGGEEFAVVLPGNDYVGAFLVAEKIRRAVLQAEIAHSDSPEGAVTVSVGVCAS
NGASQVRSEDLIGAADKALYVAKASGRNMSVIAN
>A0A375BBN5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLSALLDRLWEQALRTPQRFVVLSFAVASLLLLLIAAHGLTLLRDHEIQSLQQTQQL
QVAGISSVLNVEAERLMSVRSFAEHQIRLQTGPHAVATDPPLQQAYNQRNQDLWMLPVPE
GDAVLLGVGPRLLSGLAGFARRDRDLLPGLFVARGLSHLLSAEPPSPLVARRLLYVSTNG
FFVAHPPVPATAAAATLQHVAGAGYLTMHTAAANPQRTLRWDMQAASDGSGDSALALSVP
VYLNDVFRGVAITELSQPSLDQYLSRTSRPSVQSFLADIDGNLIAASAGSVRRGETLSMV
LPPAWREATAAEMFRRGAGTMRFHDGSRIVFQRIGSTGLVLVDYFSATQMLWRVVSQLSA
SLAAAALSLGLLLWVTLRGFNQLFSHYLARGEALREMAETDALTGLANRREFESRFGIEY
RHSLRERAPMSLLMIDIDRFKRINDHWGHASGDRVLRTLADVLRATLRTIDVPARIGGEE
FAVLLPRTGLDEATRLAERLREVLGQTPCDPAADASDKGPIRFTVSIGVADAGADGTDGL
DTMLMVADRRLYAAKNAGRNRVISDDCVPEPRPEVPAPMGG
>A0A8K1ITT1|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MSNPVPDPGDILHQIAWSIRNSQELPEILSRSVEGIQEFLKIDRVKLYQFEVDGSGVVVA
EARQGDRLPALVGLHFPAEDIPPTARQTFARIRQCMISDVTRSCKTLFPLDPKLPPYQEP
VSDCHIAYLQGMGVQATLTLPIFERNGLWGLVSIHHSQPRYFSNYEQQILQLAIDQIAIA
ITQARFLEKARENQRHEKALERITEILDDDRDDEQSWILSQQEVLKEAVSALNASGGRLY
LCSQPEIEGVNLAVVGDGAVVEQLEEHPQWQPGFMGYNPLSLDSSPHPEPISLDAETWKE
NQALAFLWDVLTPTPVRSLLVIPLQYHRQCVGYLTLFRRGHNTDVWWAGKTTSDERHQRP
RASFDAWRESHRDQTDPWTSGERKLAHQLGIHLYIAVVQHRVSAMLRYQVSHDPLTQLPN
RLLFDEQLSLALVEARQRQTSMAVGFLDIDRFKAVNDSFGHHVGDRLLKTMTRRILSCLQ
EGDCLARWGGDELVFLLGSRSCRQGVMAVAENILAELRQPFECEGREFSISASLGLALAP
QHGRDNGSLLRYAETALDWAKQQGRNSISLYNPDMLNSRADTLALELDLEQAILNQEFCL
HYQPQIDLASGKIVAVEALIRWQHPERGWVPPDRFIPIAEETGAIHAIGEWVLRTACQQH
RDWVKMGFKPLKMAVNLSARQFQQPNLLGTIVEILETTQMKASYLELEITETTAVKDVEL
SISVLHRLREMGVQIAMDDFGTGYSCLSFIKQFPLDTLKIDRSFVRDLTQDSSDAAIAKT
IVALGQGLNLIVLAEGVENSEQAEFLKSIHCDLAQGYLFSRPVPETEIPDLLQQWAVFQG
IEKVTVLSTRRPRYGSQSSLPETAERRAFLQRRIRDLEQANVSLRRDRDELQQSLQRFNH
HLHWEEHLTSLSRAILGKQPLVVVFQQAVVGIRRELGLLSVVAYRYDFYGNTIPIAEDGG
HHHRRPAAAPDLYSLVSKPSPDVLALCNLDYVHLSVDDAVVLAEQRVKACVLVPIYQQGS
IWGAIVLHQAAVARNWQPKELAWLEKIANLLLLMELPHSSPGESVLSYDLLTGLPDISSF
ESRLRYEWGRLIDTQLPLTVILADVDGFEEYCQRHGQETGDRALKTLAEAWRDSLTRRGT
CLVRWQGEQFLVLLPHLDTSQGRAIAELLRQQARRFIATQLTPTSLTVSFGVASDLPNPN
LEPESLLETAQLAVRAAKASGGDQVVIAPDVHLDSANPNWSLLSNLQKGDTHD
>A0A8K1IPW4|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MLIAPPRFRTRTGHPESMCSSSPVQHRLRQWRARLGAMVGTSGIILAATTGGLFQMLEAA
MLDRYIQHRPLEAPDPRLVLITIDDDDIEAAGEWPLSDQRLAMLLEQVRSQQPRVLGLHL
YRYVPIPPGSDDLSEVLATTPNLIGMERYIGKSVPPPPILQQLNQVGLADMVMDPDGVIR
RGLVSVRGNDGRIRNSFAAALALMYLQAEQVPIEPQGSGSSRVQFGKSLIESLRQNDGGY
AHIDDGGYQVILNYRGTRGNFETISMSEVLAGEVPDDLFRDRIAIIGLVTPTYQEHYNTP
YSNRVRDRYTQMSSLLIHANLTSQLVSAALDGRTMIRFPSPALEWIWVFGWASAGTLISW
YWWQTSQFRNHKSPAWGLLSLYLGGLCLIPPLIGYVAFINGCWVPVISPISAALMASFLV
SLHNVHRLQKLATCDGLTQLGNRRYFDLYLERLWSLSLRRQQPISLILCDVDYFKPYNDT
YGHRQGDDCLQQIARALTRSVRNGDVVARYGGEEFAIILPDTSVKDAMTVAQRMNDMVRH
LQLGHKTSVVAPYVTLSCGVANLIPQPSNSSHELVEAADCALYEAKERGRNTCVLRQISG
QTSSEY
>A0A378JCK6|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MQIDFLNREELQEFIFQFEQALYNHQQWYNSIIRSLVCRLPSDQHDISVNAHKECRFGQW
YYGPSSHKLKQHPAFIALGEEHQYMHKAATTLLVSINKDNNISPHDYDIFSNSIEKLHLE
ISALQRELNELLYSRDPLTGTINRNNMLPVLREQQELVKRQVQLCCIAMLDLDKFKTLND
QHGHPAGDCVLATISRFVIESMRPYDKVFRVGGDEFLLCLQNTNTALALEIIERIRSGIA
KMTININSHESVHITASFGLTSLKADISIEQAIDQADQALYKAKKEGRNCVRII
>A0A5X3P5D6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weslaco|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRTAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1V6HSK0|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MRGIVADPFSFHTLLSLTAAWIASVVAAMLGARRRETPGGPQLFWLMVAAAVWALAAAVE
LMVTSLPAKVFCTRLQYLGILASPVLFLLFAVRFTRRRWLDSPGRVAALCAIPAVTYLLI
LTNGWHGLVWPTVEALSSARHLAAYASGPVFWLGVGYSYLCLAGAFWQLGIAAMRLPRAL
RHQALVILVGSAIPWLTNASFIFRGFPVPGIDPTPLSIAAMGVVIGFAVIRFDLVDLVPA
ARATAVRLMPHGLVVFDEQGRIIDRNPAARYLLGPPERTDSDGFGLRDTGPWSELLARTL
DGPLGRFELSVPADPPRILEGEVAEYRTPKGTVSGRFVLLRDVSERYHAARELAAANQLL
ESRLAEIEALQESLREQAVRDPLTSLFNRRFLEETVERELVRAERTGEPLAAVLLDLDGF
KLLNDRLGHAAGDELLRELGLLLRNKTRRSDYACRYGGDEFLIVMPGSNAGEAMARADDL
RLAFAGQYGRSDRQGIVCTLSAGVAVYPDHAGDLHALLAAADLALYAAKAAGHDRVVVAT
>A0A1H6FDR1|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MRITYPRDIQINMLQRLKHLFSTSIRFRLTLGIALIQILTMSLFALSITWYQHHFLELSH
ELTHATYLQLLEKMAGGILLFILVTVLIGTGLVAMFSHHLTVRLSYLLDAMQEIRGGQRH
LRVDASGKDEIAQLGDSFNLMIDTLSIREVELQNTRERLMLAMRGSNDGLWDWDLQTGRV
FYSTRWKRMLGYRDYEIHDTLDEWRKRIHPEDRELAQQNLDWHLQGESLQYESIYRLHHK
AGHYLWVLSRGVALRDEESNAIRMVGTHTDISQLKETEAQLSATNSRLGKLIESMHDGIL
VEDENQQIILVNQNFCDHLGLDSPAAELVGQSHEQVLEQIACREMDAFMHRIKQLEAEKA
ACFGEVFSLRNGRILERDYIPIVVAGQFRGQMWQYGDITQRKQMEVELFNQKERLLVTLD
SINEGVIATDDKSRIEYLNPVAEQLTGWQESHARLQHLSRVFPIIDEDKQQALPDFSRQI
LEATQAFHQQRHIALVNAAKQQYSIEISAAPICDHTGKRTGSVIVFRDVSKAREMETQMR
WQATHDVLTGLANRRQFENTLNKLLEDAKLHQHQHILLYLDLDQFKIINDTSGHRAGDAL
LTQLATLLQAQIQENDLLARLGGDEFGVLLHDQDLNSAYEIAERLRSVVSSLRFDWQGKI
YTIGVSIGMTQIHTLSGAPEDVMSMADIACYAAKEQGRNRIHIHEANDQKVLQHQGEMRW
TNRIRHALEAQQFELYAQAIKPLTSSVTTTETAGLHVEILLRLHDETDGIICPDTFIPAA
ERYNLMHLIDRWVLNSVFKQLSPFCKMNATHPVLDVCAINLSGDSLGDENLLSYIQELFT
LYSLPPEKICFEITETVAVSNLVKATHFITKLREMGCRFALDDFGTGLSSFAYLKQLPVD
YLKIDGSFVQDILKDESDHAIVEAINDIGQTLGLKTIAEFVESPEIEARLQAMGLDYAQG
YGIERPMALSTWLKKNFPS
>A0A0J1N4Y0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. MGH109|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>W0A0N4|diguanylate cyclase|EC 2.7.7.65|Aeromonas hydrophila 4AK4|TrEMBL
MQVVESGMDKILQTLSERVTQARDLESLTRPLLEMLEAVTGLESTYLTQIDVEQGTQSIR
YAKNANGLAGLQIPEGMTVDWSDTLCRRAIDEGRLFTDNVAECWGDSDAARIMGIRTYLS
SPVRTPSGSLYGTLCGASAERKPLVEGAEQLIGFFARLIAEHVEREQLLLQLQRANDELS
RQALCDPLTGLPNRRALMQELTRLFSLSDRVGHPVLIAFIDLDGFKQINDTHGHEAGDRL
LTTMARQLGSALRSGDMLARMGGDEFVAVGMGPIPEEETVEAAVRRLGRRLFEHSVLQLP
LSSRVLHYPGASVGVVAVDPAHTSVDEALRQADARMYEVKRQRRALG
>A0A7W9S3E8|diguanylate cyclase|EC 2.7.7.65|Aquamicrobium lusatiense|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVITASSGAEALDICETTKVDVVLLDVMMPEMD
GFEVCRRLKSDPATAHLPVIMVTALGQVSDRIRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKMLTDELRLRTATATSIGLANILSRGDNGSDLPAKVLLIDSRVEVFERIRSKIRGEME
LEFASDPNAGFFQAAEGNYECLILSTVLPNVDPLRLCSQLRSLDRTRFLPIILLAEQDDD
PRIIRGLELGVNDYLVRPVDPHELTARLYTQIRRKRYNDQLRASVTQSIEMAVTDSLTGL
HNRRYLDSHLQTLFDRAVARRRPLSIMIVDLDRFKSINDTYGHDGGDDVLREFARRLRQN
MRGIDLICRFGGEEFVIVMPDTEGAVAAKVAERIRAEIARTPFSVGRQGNPVEITISVGV
SSVKRQDDSVAALLKRADLALYEAKKNGRNRVVAKAA
>A0A5C6B420|diguanylate cyclase|EC 2.7.7.65|Symmachiella macrocystis|TrEMBL
MPLISFVNWDAIPGVAHAAFGGWGVTALGVICILQYVVYLQRTRANQDETASAFHEIRSE
LDNIQKDHRITRLENRLLREFVSETDVDRAIRVLLNNLIPNTDRGFAVSLEISDKNISVG
QSRGLSREARKALIVDPEILARAAGGEPFILEGQEFRTSCLAGSLTVADRRHIHRLFIIG
IESEDALSGLVIATHMFHAETADQRHFALLKQLVQRISELRRAALALESQRHELTRTNDI
LELRAITDTRFESPVDMIQEFMTALRGKTAANRAVLYISTTAEGVSRNSFVRCGTVPNPN
VERQLCQAEDAIAAQAHSTLTTQVFNRTDLLRHGIRSFLTHALAVPLVRKGATVGAICLS
RDSSDKFHDADLELAMWAADYLAGTILNALQHAQVEQRARTDGLTGMANRASFDEAIKNE
VRSANETDGYCSLLLLDIDRFKVINDKFGHLVGDHVLRSAAQTVLASLERLRTQDRVLAA
RYGGEEFAVLLPGVNETGAARMAEVIRTAISDHTFVFAGATIPTTVSIGVATLPKHAEDV
NQLIAAADGALYYAKESGRDRVAIARSTDPRRDDTPVTLPGASQSL
>A0A1H6FDZ8|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MLPLTGLERAAYTAERLRESVAGNHFEGIGQLTISIGVAEYHKNNEMISLIEQADTALYQ
AKNKGRNQVAVYDNSRSHFISDTDLVDAGNSQDNAGNNHPDDAAND
>A0A4D8Q2A7|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTNSSDTRSPSDSLGLVLDEHLRWIGQWHRAVFFRGGQGGERVSAPASFAAWCVAVNADD
LAHQPAVEKLVTLHEQMHRKAKLLLLKAAGGESPSEADYEGVIARFEEFVLHLRRVERAF
GAAASGLDPLTGLRTRRGMQEALEREHNRFRRNGPAFCVAICDIDRFKGINDTYGHDIGD
RVLAATAAAISRGIRSFDEAFRMGGEEFLICLKETGLAEGFRVIERLRGELARTPVTLPD
GRRIAVTASFGLVEAGEDLPVEEMVVCADRALYQAKNSGRNRVVRYGVDQPEVVAGRSAL
PHRR
>A0A8J7R0R6|diguanylate cyclase|EC 2.7.7.65|Tianweitania sediminis|TrEMBL
MFFEPFLPGLSGTELLLAALLFVSLVFSASTLFFYRRLQGSLATAEESSAALIAHLSDGI
YRSSLDGRQLSANPALVRLNGYDTEEEMLRSVEDIAVEWYVEPGRREEFRRILQAEGHVS
NFVSEVYRHKTRERIWITESARVVRHGRTGKPLFYEGSVREITETRRRLNQEALFQKLMS
GVPGGIFQLKVGASGISAFTFLSPGFERITGISVQEILRDPATLTQHMHVDDQQRYRTSF
LEAASTLHSWEVEFRVETARGGEKWLRLTADPERSADGVTWHGYMADITIRKRQHAQIEA
LAYRDPLTGLANRRRFFRGMEATMAGLRDFGGTAAVLFIDLDNFKFLNDTAGHDAGDRCL
KDVAAILQSNTAEGEIPARIGGDEFVLIIGGSLMDEAEMTQQALVRGNQILSAIRHGCGS
HQVSASMGVVVFDGSSAGPDDVLQRADRAMYRAKQAGRDGLAICDLRPASETLKPIELLS
LAAADTEQSLDTFQPRRRKLN
>A0A3P8K687|diguanylate cyclase|EC 2.7.7.65|Tsukamurella paurometabola|TrEMBL
MSPRSRRYGRNVRRLARILTDRSGWREAGRAEYAFATSGIIGQGGGLALRFVVSALAIVL
LPIGVVSLFLPIGPSTPAATVAYLGGSIGGAVLGVWWLLRRRRSCRDAIVFVACADVLLL
ISALTMSGYGLVGTTMYFGMLAMLVAFLLGWRILLLHCLFSTAAVIAATVVTVHAHGIAF
GELYPVVAPAATIAIALPLIVQFVVEAGRRGLGQVTLERDHDTLTGLYGRRGLDAEMRRR
LRGDADGVCVVAVLDLDGFKAFNDAYGHQAGDRRLVETARCLQAGIPTAALARMGGDEFL
IVGTGARRADVEAILGAVRALVVAQEGPPLIAASVGVAIVPVRDPRRLPEAIEIADTALY
EAKADRSLRIVVRDPCGAVAPAQAPTDPDPRVSGVTAPQTEVRSAPPDR
>A0A151ASQ1|diguanylate cyclase|EC 2.7.7.65|Moorella mulderi DSM 14980|TrEMBL
MNLERFYPIDWLRVACKGSKFFIYLLILAWLVWFIRTSQLRVRKRTAVVLLFIGLPLVLA
GISLDLVGEFFRLSTLLKRIVGELILSNTGTFLVLYSMVLMVMELARASCRYQREAESDP
LTGLYNRRAFFASAESVLKEAREGKRNPVLAILDLDNMKKINDTWGHQYGDEALKRVAQA
IQKSVREGDVTARYGGDEFVILFPGKGPRLKTLRARLERHLKAIRFSGTEIPLSLSVGLA
RFPADGKDVDALLAVADARMYADKEAKKGRQRAGI
>A0A239RRF7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MFRKSSNTSLQKIFSQSQLLIFALTLGICSLIFVVISIYTMNTYAKQSLNIFSATLSEQI
QPAVIFNDPITLQQTLNNHIQQYPIRAIQVINLQGKPLAEAYKPTPEFAWMENLFDKVFF
KHPVTRTIKHQNNQYGTLIIYGSATQLMSFFFQLLICLSAGIFVILLIMLWLVHSTYQKL
MHSIQPMVNTVESLNLDTQYQARLPSSPIYEFRVISGAFNNLLDKVQRTNEKLQSENSQL
SHQALHDQLTELPNRHYFYNILFNQFEHPEKNQTTLFFIDNNNFKNINDVYGHLAGDAVL
KEMAQRLKKNVRSHDVVARLGGDEFAILLRNIKHYDHLELICEHLIECSKAPLSFDQHQI
HFSFSIGVAFSKCATTPEDLIAEADNAMYKAKNLAQGWYITPCLNPDQEPSC
>A0A554X5Q6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MSATTPKEIAREAVRLLAARRLPPTPDNFQAAYHEVAGTRPLQPFPLAQLRQIAQALPER
TPAQVRFKALFNKAVSRHTWDDLEKVLTQHLAAAPAPASTPTAAAAPATPPAASPVTDGP
AASGFGPSDFAPSAFAPDAAHAPPIAPEIAEQTARIIDIAQPLVAADDRRLHDMGEELVR
YLRLPEHHPPTLRRMLADYAYRLSFGVEEQTGVREALLGLLRQVFEHIDAISPDNPWLRQ
QMQALVQAAQPPLSQRRLEDLQARVKDVIVKQAEAREQTVRAQELMRQTLATFLERLAQT
AASIGQYHAEFEACAQALERAESLADMAPVVQEAIQTARAFAADTQRVADELTDLRDRAN
RAEAEVERLRAELDQMAELVTHDLLTGVLNRKGLASAIDRETRRAERTGTRVCIALLDVD
DFKRLNDTLGHLAGDAALKHLADVARRSLRPQDTIGRYGGEEFIIVLPDTTPEEACGVVQ
RLQRDLSAHLFLQGEQKVLITFSAGVTELQHDEPVDAAIARADAAMYRAKRAGKNRVMAG
>A0A1G4FQ79|diguanylate cyclase|EC 2.7.7.65|Sporanaerobacter sp. PP17-6a|TrEMBL
MKFINNRFKIVTVLHHSTKDDVYIVEDLWNNEEKKFLKFFNYEEHGKLIDYLTENFIFIS
SIKHKYLLSCEQFDICRTVDRSTVNINKYYYVSEYIDASTLAQIRDELSVKDKVFILIQL
CAVLNFLHFRGIIYKSLNPENIYVLKNREIKLRNLISTFEDNLENEYGKNTNQFILSETL
LKEKSKDIKTDFYFLGMIIKYLFPDEILEKGQFQVIENVYDNLVESNKDGKDINLSHIVN
KLSSAFHIRYEYDLRKERETINFKTKMVGQSEELKRVLQICGDYHGRRCNKKIVLVSGEP
GVGKTRFLKEVSYRLKIKGIDVYNSYITKKENESFKVIRDILRQAIKGIPKLLLDKYGGE
LVKILPELNLAKDIVPTPSLGENEDKFRLYDRLLNLMDGLSKIKSLNIVIDNIHYSDIET
LTIIDYILKSPKEFSIAFILSDSGDKISDSNVSKFLEEWRAKGYIEDIKLSKLGLQEIGE
LVQYILGMSFKPLNFSASLLKETLGSPRFIELILYDLCSKGELRINERGNWDLINKTYSE
VYLPVSFDNTLKKQLNSLDDDSLQVLKIISIFNNPISKNGIIKMVNMDVNRLNEIVDKLV
KADFVDERVGDWGYSYIVYDLKLKKMIYYSIDPIQKKELHKKSAVILEEEYKNNKNIDLE
ELIYHLIQSDQMDKAIDYTINYAKEMESLLNSQSVLFWEKAYDLLKDRKDERKLQVLESI
GRLYILRYQNEKALKVYKQLLEEAEQYNSVKYIVDSKNSIAQIYYKKNDLDSAFKYSFSA
KNIAKDVNDIEGLLNSIISLSKIEIYKGNYDSASKELLAGLEISEREKAEKSIGYFYNLL
GIIDYYSGNMEKAEKNFLKSIEYFERTEDYVEFIKPLNNMANVYIEYYGDIDKAIEYYNK
GLNISRKIGDLDLEMTFLNNVGEIYIGNHDYENGKKYIRKTKEIAENIENGNMLFLSNIN
LGNIYLTTGEYGLCYNCYRELQQGYIKNPNKEKEALGQYFNFMGEFYYTFGMWKKSLKNT
YRAIQMCKEFDMRDYLLSKIRIILIKYYEQSKFDKEHIEEIRKEFRKRKYNFDRRKALLQ
FSTIAILEGDLDYAYDLLKEDEDLVQKYHKDSLDFIRNLLLYYLDGNNGDSSKLMYLENE
MKNNDILYFEFYGNFIIADKFYQLGDYYKSLKFYTETLDALYRLTIRIPDKKFQIQYIKI
NRGNEIKQKMKSIFKEIFKKDIPYICLEDLEKEDSIEKYFEFEKISELIDNDCLRKMLGN
STDLQFTNKIKNLEDLIVNFTDNYKENLHLILEYLAEKTIAQKGFIFSYDEKNKDLSLVV
SLNSKDSDIIDENILKIIGENSTGVIIKNTPKELKKKFFTESLSKENKAFICVPVYKPNG
YINNFVHKDRRKHNLKNEKIIGYIYLQTDKLFNRFDYERYQVADLLSYLVFMNLENYNLK
IMSTIDAMTNTYTRKYFDIIINDIMYNVKINGERFALLMIDIDKFKDINDTYGHRKGDEA
LSKIGNTLVQNVRSTDIVARYGGEEFIVILQNTSEKDAKEVAEKLRKKIEELNIENSSCL
LTVSIGISIFPDHSQFKEELIEEADQALYCAKENGRNRIEAWNSNIVNSFERVDRLAGIV
TGNTVQDQRNVLALMDMVDLLRKDNSLRNKIYEFLGRTMEILSAENIILFTLSDSGEIEK
SYSRKRFTKGFSRLPYYNKGILKKTIESKKGEFLIDWEDIGDVDALSGVPNWKSIVVFPL
IYKGIMKGIVYLSVSLKEKEFDYNSYNFIKAICSIFSPLLN
>A0A1A8TJW9|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MTLNAGAINHSFTNRSRRAFIINLFCLVGVLFTAPLGVLSLFKGNLLVGSSLLTIATIYT
LNHLYLRSTRNYLFSANVILYPLYALMLYLVYSGGVNGTGHVWIYCIPPVSLFLHGLKRG
LLEVFLFICALALILFYMDSPFNDLDYHPDLKSRIIYSFILIAFLSTIYEYISSRFNQSL
QELSAKLELAATTDPLTGLLNRRGMEQQLEQQAWDAPAVLLMDVDHFKRINDEFGHEYGD
EYLQRVAYSLEGLLSKYSCLISRWGGEEFMVVLEHPASMKDVAELLRRGIASAVLTTSLG
ANISTTISIGVTEAKVGESVIRALGRADKALYEAKDNGRNKVVIAQKESP
>A0A239RUS6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MSGLIYPCYVLHDRVWVQRFLPYVAIGIFVISLCQDSYFVGVLSPMTMITYMCLLTVGLV
LFKRKIIYIMLILATSFLVFSGYLSFIDVMPYSPLFTINGKLFYNGFWLFSMLYFIAPIL
VTCLILFEILLSQWRHRERLIQHLSQTDPLTNALKRRSINQSLDELHHDKNCPYAIVLLD
LDHFKNINDQFGHHMGDTVLIAVSQKLGLHLRESDVVGRFGGEEFILILKQSSALKARQI
AERCRAAIEDLVIQNENGRAIRITASFGIALAADKLKPQQLLDQADKALYAAKASGRNQI
KCYLEINPSEIKYSAACADTQHISPN
>A0A5H5SVR1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kottbus|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1L9P172|diguanylate cyclase|EC 2.7.7.65|Planktotalea frisia|TrEMBL
MPTLDWPALDAAFDILCPMHLRLTETGHIVHVAPTLKKLRPDADLTGMRFLEVFRLDRPR
SITTMSELMSRARSKLHLELREAPCTSLKGVLVRLPKGQGALVNLSFGISVVEGVQDFGL
SSADFAATDLAIEMLYLVEAKSAAMDASRNLNQRLQGAKLAAEEQAATDTLTGLKNRRAA
DRILETAIEEDRPFTLMQLDLDFFKAVNDSKGHAAGDRVLQEVAKIMRAETRKGDVIARV
GGDEFIILIEGSAEKDRLKEIASRLIRGIEQPIKFEDETCHISSSIGIARRLVGDPRGMD
ALMQCSDRALYASKSKGRACATFDDDLVELY
>A0A0Q0KWT7|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MAFSEGYDAIKSHLGLDIAQLILDSGDAGIWLWNVQTGETIFNDKWADIIGYTLQELLPV
SIETWLSFAHPDDLSKSEQLLNAHFKGDSKRYICEARMKHKQGHWVKVLDKGQVQSWDEN
GNPEWMLGVHIDITEQWLKEREIEFLHAKLQKFTDNLPGFVYQYVVEKDGTAYFPFASSK
VFNIYGCTADDIKNSADLIMQTIHPDDLERVVKSIEKSRVELCEWHEVYRVNHPTKGVIW
VEGKSSPIARANGSVEWNGYSEDVTEEVKSNEKIQLLTAVFSTTSRGILITTPEPKIVDV
NPAFEQITGFCKAEVLDKNPSVLSAKQQPTEFFELMWECLIHNGRWQGEIWNKRKTGEVF
PELLTIDAMYDEHGQVSHYIGAFDDISQAVEKRQLLDELVNQDPLTKLLNRRGLDIQLHS
FSHHAANEGNQFSLIYVDLDNFKLVNDTFGHEQGDNLLLEISEQLSLQLRDKDILARIGG
DEFVIVLPTLAKLSVCQDIAGRCQKAVEGVAKRYATKVPVSASFGIALYPEDGKNAKELL
ATADEQMYKMKLKHKASPLG
>A0A1H0SZ99|diguanylate cyclase|EC 2.7.7.65|Ralstonia sp. 25mfcol4.1|TrEMBL
MSWRKLLPRPRWLPRAALIHPQRVVIVGFGLAMLLMLIVGARDLYLLRDRVLSSRQHDLT
LRALGGEAVFAAERSKLVFVRDYAQQLITLYDSGAAPADPAVERAFAQRNDRIWQMEVPL
GDSPVVGTAPALLDELEGFERRDADLRADLYAARQLSHVLGLSLRLRQGENADGTVSYIS
SNGLYITYPPLPPDKAPALFRRFSHIAYYRDMLPERDASRDIRWTRVYTQFESTQLRTTL
SIPVYVENRFRGVVAVDVELARLRELLGVPEDAGTTRYLMDYRGGIIASSQHNVRIDMRW
PDDVDQAWRGVPAQELFGAGAGIRHVDGQYLIYQPVGQRGTWLLVESFSDADVWRAVLQR
TSTPLLSIWLALPLLMFVTLRVVTLLFRHYVAAGETLQRLAETDPLTGLANRRHFGEAYG
RESARRRREREAAGADESLAGGAPARVEASPAAPLSMLMLDIDFFKRVNDRWGHASGDHV
LVALADVLRRNLREIDLPARLGGEEFAVLLPQTTLADAEATAERLRAAVQGTPVKPAPDA
PPPREGDGHIHFTVSIGVAEAVSDGCPTLDAMLATADRRLYAAKQAGRNRVCAADAPAGN
TVAPSVQG
>A0A6L5EGW7|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MEMYLKRMKNEWEALVENTHPHIRQLASEIAKAHAHTLSIEFYRDVLTDPHAEEFLSNEQ
VERQLKNALELWIINVLSCKVDDIDQLIKDQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDGHHDSIEKLQVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFTLLENAEE
EKERQIGALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHNANGSTKALNNKAARVKFLLQIRNSISQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDDILRRVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEANQTDTLRTAERIRSRVEKTKIKSPNGEIIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A859SYH1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPTLNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVDVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>I4EVA9|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MPETQRALLLPGAPGWALAVPAVALCAAPSGLTAWTTSGTPPTGAGLLLVAAVQLALTAV
LCWRVRRVRHERALWTRLAVAGLIGAVAVAASGVLLLLPVPAAVVPLPVTWAPLLAFPFA
YGGLVRWNRYSTSLADPNDVLNGSAAVLAVVALLNVVVDRSGSELAGLPWWRLQPLLAQD
ATLFVIAGTAFSMVFLGAMGRDPRTWLVVGAFTVQLAGAASTTLAGGDPVVWAGAAGAVS
AACLGLAAVWSPPHSTPQPADPTASTVGAFVVIIASTSILVTGAVSDSATGLATWCAAVA
ATGSSVRLLVNVRELAQLAVSRREALTDELTGLANRRAVLRRVEELCDDHEPVVVALLDL
DKFKEVNDGLGHSAGDDLLRLVAARLVPVLAPVDVLGRLGGDEFAVVARVPAGSSPADHA
VRLGSAVGQQLTEPFQVGGLSLHVSVSVGLTHADGAAGGAGDGQAMRALLLRQADAAMYD
AKRSGTRVVVYDGSRHVDSSGHLALVEEMRHGLATGQFVLHHQPQVDIATGRTLGVEALV
RWVHPSRGLLTPADFLLQAEVHGLMGLLTDTVLRQAVAQAAAWRAAGLDLRVSVNLSASN
LLDTELPQRVADLLRAAGVPPSAIVLEVTESVLLSDPERSLAVVAALAALGTTVSIDDFG
TGYASLTYLRELPVAELKLDRSFTADLLTDARAAAIIASTIGLAHQLGLRVVAEGVEDRA
TLRDLRQLGCDESQGYLHSRPLPAAELEAWLATQRVDARPALLG
>W2UGY0|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium MOLA455|TrEMBL
MTDLDSTDSIPTGFLSFSLVSQEIISVLFAFYSYYQGDMDLATFYLAMAALLLVGLGIHS
IFDRPHTARLVLAIVLIGGYFYLLSGASDGSSLLWCLTIVPVLVGCFGYRRSVLILTAVF
GGSAWLFYGPSLFILMPPYSDVTLVRFLSSFAVLSVFAIAMDNSHSRSLNRYKDLSRRVD
QIAHQDQLTKLPNRHDMEQRLEKKYQQYRLVNQPFSILLADLDNFKFINDRYGHDVGDEV
LHAIGALLSEPLRGEDVVARWGGNEYMVLLPTANSEAAVNIAERLRAQAGKLAMDAQGDQ
LRISLSVGIASIDKCTGIDDLISTAENGLYQAKHMGRDMVIVG
>I4EQS1|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MDAIRLEESQDVLVQSAAVVAAQRQFAQRLRQRTVPDPLTGLPVRSLLVDRLELALAAAG
PQSGRLAVLCCALDGIGSLEDQHGPAVADAARAEAARRLVAAVRQGDVVARTSAQTFVLL
CPGIGAATDAQRLAERVARAFDQPLQPVPGVRALLRLSAGVALSGRASSPESLLAAADEA
LRSVRQA
>A0A2P9ASS2|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium delmotii|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTATNGLDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKTLTDELRLRASTTRNIGIEELLSRNFASADTTPKVLLIDERKSSFERVQKMLRGSAD
LDIATDPHAGFFQAAETPYECVMISTAFVDFDPLRLCSQLRSLDRTRFVPIILLAQEGEE
GRIIRGLELGINDYLMRPIDQQELTARLRTQVRRKRYNDQLRASVTQTIEMAVTDALTGL
HNRRYLDSHLQTLFDRAVARRRPLSMMITDLDRFKTINDTHGHDGGDEVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGAVAEKVAERIRAEIAQMPFAVGHDGKTIEVTVSVGV
SSVLKGVDTVAGLMKRADLALYEAKSAGRNRVVANAA
>A0A8F9HRJ6|diguanylate cyclase|EC 2.7.7.65|Polymorphobacter sp. PAMC 29334|TrEMBL
MARAAQRTRANPLGTNTDVGARLRAKALMSTIVQQIAAMRNEERRLLSVRTYNARNEVQQ
ARALLVYGFPILVLLIGGVAWLIRTGISRPLANLLDVVTRFGAGDRSARASTIVRSVEFR
RLASAYNDMAARLVNAIDTQEARQQSVEMLSEMAQRLQAIQADGELSVVLGTFMPRLLPG
VAGALYVHNHSRNMLFRISSWGDLQSSPEMFPPGDCWGLRRGKTHLIEDPGADIVCAHVA
YCAAERRCEPILAGGEVLGLIYIEGRIEGEQRFRLDALMESVALALVNDNLRSRLREQSI
RDPLTKLFNRRYMEEALALESGRAERNGAPLSIVMCDVDHFKRFNDGHGHEAGDILLAAV
AGLIQSHFRTGDIVCRYGGEEFTVIAPGASSTLVQERVEALRMAVRELTVLHQGSKLGPV
TMSFGIDTWSAGGDRPMSTLVLEADRALFKAKRLGRDRMEIASSVTESGRTELASPQIVR
LQASG
>A0A1V4VJL3|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin104|TrEMBL
MNRDRLKLYDHIIVTKNNLLKGVVSVQNLLDTMTRIRLELARGANPLTGLPGNISIEQEL
LKRATECPIFSVVYFDLDNFKIYNDKYGFENGDKVILFTSKLLNSVINKYGSEKDFLGHI
GGDDFIMVTERERTDALCKRIIRYFDRLIKSFYLPEDRKEGRIPGYDREGRAKWFPFISV
SMAVIECEGSEKADLKTLSEKAAQLKCYAKTIPGSVYVRDRRGRVGLTDSG
>A0A514ET12|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MFQKKPFLLPLLIAFSSGGVILTTFLLLGGIYLFQKKEIENSLLESNLAYAMKIADTTDR
YLAMAQRELAWTASELHSTDTSLARHEIERLQLRSEVFNSVGVVDTKAVIIATSPYLPAL
TGLKVHSDASQNALAVQQPLISGPFTSVAGNEIIMLSHPLRSSDGHYLGYLGGSIYLKKQ
SMLSDIISLHFYKDNVSVTIVDRDGMVIFATTPSKTTPRLNLSPQLKAYMSNNLSGSFVG
RDRLVGYAGLKKSDWNIIVSTPSEVVTSMLLNTAKKISGLVLAILFFIATGVAFLSLRIA
KPLAQLARLVQATDSLTSPEKISSIRAWYQEAYLLRDAMEKRFRLVSAQFAALSDEAMTD
PLTGLYNRRGFYEQLTYIKNLKNQCAIAVDIDHFKTINDRFGHSAGDAVLVHTADLLKLT
CRKGDVISRFGGEEFVVLLSETTLAESAAIAERIRQVISATEFTEAGHLTVSIGVAGLKD
YASDYERLLMEADSALYQAKRQGRNRVVVSEHRQ
>A0A449BIP4|diguanylate cyclase|EC 2.7.7.65|Acholeplasma hippikon|TrEMBL
MYRLKYSEEWEIKQYSNQANIVYLSSIVLTTIILLILTFSKDIFLIVASSFTLITGIITY
ALNRKQKYALASTVFILTISINALFHHLYLGFESGFVFYVFNICALIIFTKWEDKTKQIW
IMIEVAIFLVASLYVLIEGILIPGVMLNQNWFIFYFSINLVMNVIGVANSANFYVKISKN
AHQKLVELASTDSLTGLANRTSFEYKFSLIAKNRSEGVGILMIDVDNFKQINDQYGHTVG
DEILVKIGSLLKKYENNECFPSRIGGEEFTVLIHTNSAETVYKYAESIRKTIQSNKFNLN
IPVTISVGAVFKPKDLFKDINLFSEADNLLYNAKNDGKNKVKFKKFTVTDITWKNKKK
>A0A423XS30|diguanylate cyclase|EC 2.7.7.65|Cronobacter malonaticus|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISAQRNQLDSTATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIDGFKAERDKPEWTLPTGRELAPEIQ
GVSDAFIGQSTLLERNDALLYSELNATLALGHMLSIADARSERPEVRTFYVSRAGFYLTN
LPFFDHGSIPELYYQQVSSRWFIDQSQRRNPGRGVRWLHGRDLSMPSGQRVTASIPVDDN
GRWFGVLAMDFPVSAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGNDAALHFTAQD
KAMLARQMELDNEGDARIDTRFITWAKLDYFDGVLVKVTTVSQSAEGRFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
DEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTPAEGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A7M2V242|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. BDA59-3|TrEMBL
MMKENQRVLMATPNLILRLFSLGLLSFIFSLFSLQLTRFGTHLSPLWFPTALIMVAFYRH
AGKMWPGIAVVCSLGSVVATIQLFSVSSVNLWYTVINVIEAVTGAMLLRKFLPWYNPLQN
LSDWIRLAIGSALIPPLLGGILVCLLVPTDNLVRTFMLWVLSEAIGALALVPIGVLFKPH
YLLRHRKPQLLLETLATLAVTLCLSWLAMTWLPWPFTAVIVLLMWSAIRLPRMEAFLIYL
ITVMMVSLIMATHPLVGILPPKSGAMLNAPWLPFLMILLPANVMTMVMYAFRAERKHISE
SEERFRNAMEYSAIGMALVGLQGQWLQANKALCNFLGYTQEELRLMTFQQLTWPEDLNKD
LEQLDLLVRGEINTYSLEKRYYTRSGDLVWALLAVSVVRHADGSPRYFIAQVEDINDLKQ
TEWVNKRLMERITLANEAGGIGIWEWELEPDIISWDKRMFELYEVPSHIKPTWQLWYERI
LPEDREETERIIRDSLMSRIAFKLEFRIAVKDGIRHIRTLANRVLNRNGEVERLLGVNMD
MTEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWSQEQAMSQP
LMNVLRITFGETGPSMENIHSGDMSRSAIEQDVVLHCRTGGTYDIHYSVTPLSTLDGQNI
GFVLVIQDVTESRKMLRQLSYSASHDALTHLANRVNFETHLKRLLKSVQELHQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDILARLGGDEFGLLLPDCNVESARY
ISGRIIQSINDYHFMWEGRMHRIGASAGITIIDETNHQASEVMSQADIACYASKNNGRGL
VTVYEALQGQMLQERSMMSLEEQWRMIKDNHLMMIARSVASPRVPETCNFWLLSLRLWTS
EGEVMEERAFRAGLNEPELIRALDRRVFHEFFRNHATAVAAKGLGVALPLSAAGLSNSKL
VDEILDLLEHGPMPGRLLHLMINADALMRQGKEIIDNLKKLRHAGCRIILSHIGQDLEIF
NHLTPHTADYLLLDQELVTNVHGNLMDEMMVTIVQGHAQRLGLKSIAGPTNQPLMMDTLS
GIGIDLIFGDTISQPQPLDMMLNTSYFAIN
>A0A7U3F4N0|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATLG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNSQKQPFAAWRHEPLANKEQVSGLVS
KWLFPEPTVQPIWHQGKKIGELQLTALDKLISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVGHQTSALLFLDGDNFKLINDNWGHAA
GDKVLTEVASRLMAFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQSLSQLFLPPFNL
HNGHTATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQMLK
>A0A6N2RAM0|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKKNQTQIKKYAAVISIFLAAVIVGLFVFFFCIKRSVEQRSKNTMRNNVVRQSEHLRTIL
DIQYDYLNGLTEEIGKTDHLLAKKNMDLIKSITKHTDFGGTALIEPNGDAHYDNGLIKNL
SHRKYFKEVISGKRTLSDPLDSSISGSTRVVLGVPIYNSKHKVIGALGGSYDVTALSRML
FEDLFNGQGCSMIIAQNGEIIAFEGDTSYWNLDYRDNFYKCCCKWIIKDKVTVKKIKQDF
KEGKENLVTADSKKEGTRRHYFAYMPMGANGWMLCYALPEQAAQQSYNFIEDYEISFMIV
FIVLVTLLILYIVYENHTRNKELLKYAQTDALTGLYNKETTEQLTDELLSEDENKYHAFL
ILDVDCFKQINDIYGHAVGDIVLQKFGKLLKGTFREGDILGRIGGDEFGVIMKNIQTKDI
AMKKAEELLAKTQAYKIDELKGNNISISIGISTAPQDGDCYMDLYKRADQALYQAKRSGK
ARVCNYFS
>A0A2K9K243|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MMFHDPMAVAQEKMTQVCLFLEQHHLPPTPLNYQVAYTHISATNKDLDCAINKTIKAHTK
IDCVFIEQLYYQFLDQGQKTQSELLEGVDSLVTELHENAETSQKQVIRFAQQVSQCVHNL
DEHNIQKSKRALSTLTKQTELLLKQHKQFKQALIKSRLDYERNQKLLLDLRKQHLLDPQT
GLYKRHYLHQKVSLWQSQQKSVCALSIQVDNLDEFSTRFGDVVGEVVLNRIANNIKRYVV
ESGLPGRTGKKEFTVILADVDLDTASVIAEKVRKGVERLKFVSAKGKIPLPNVSLALGIA
QLAPEQDFNMLAKRAGYAAQKAHSLGQHCYISH
>A0A379QIJ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTKRSLN
>A0A5T3NG53|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSISFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U7LQ65|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMLSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAQQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0L6Z946|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MHKERYGTEEIIQIVLNHENKIQYSSINNGEAYNHLKKLHIFDRLSESSYVQFSYGKRWV
TINKIIIANQKYYVITIDSNNYKCSKLLIDSVTGLYNRNYWQQINDGSIYHHLYSKKDFS
LIFIDIDNLKEINDTFGHLVGDKAIEIVGQAIKNSIRKEDLGIRYGGDEFIILLFNQHKK
AAKRVTERVRREIRKLAVEQGMNIQISAGIACTDCLVDLEDMIKMADKNLYREKEKKKEQ
KGQNNEVNNLAKEIREIRDELNRKIDGKSKIFTSTEILELSQKLDKLIVNYLGKK
>A0A663AKG0|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDTRMQPWQLFSTRLGIAAMLISPVIVASSVEAINMLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRHLVGEQGMVARIGGEEFAVAAVVDSAQQGYVLAEKIRHGVESQPFGLGQNPI
HLTISMGLETREVGHARITELFNQLLLAADDEMVKAKQTGRNRICMPALTESAP
>A0A1V6K0W6|diguanylate cyclase|EC 2.7.7.65|candidate division Hyd24-12 bacterium ADurb.Bin004|TrEMBL
MTGLPPRKALNEDLPRLLKMTATERLPLCAIMIDIDHFKKFNDRWGHSIGDRVLGHVSSL
IRNCARYRGEAYRYGGEEITVLLINFNTGEGLAAAERMVETVRSTPMSIPGNDPAIPVAA
RSRDGEPVRLEVRISAGVCSTRDVTGAELLVMADKALYEAKESGRDRAVGFTPGLNAEKR
TSTISVRFQGKSPILDRNRLIIKAWFPIRLSGSSAAIADMEQIEAREIRFLESNVSEVIP
EASPAGGLITLEIPGRVVSVENQGKYTFFEFDVREEVFEMIQTHRANWKSGGPY
>A0A7U9CWJ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae KpQ3|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFITVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A8E0FU59|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 9.0111|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A2S5D1X4|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MELTLEQLNKTILEMRTKGRLTEALTLAEQGLLVALENDNHRHGLDLFFQKILIHHALGD
TLSMVRHIQEYEECCQKYGTKKDFMNYNLVMSLIYDLVGFREKTVEMTKKSIEYATQLKD
IKMLVRCHSNLCYLEVENGCYMEALEAAFIARNYNVELAKTLPELAKLQEIRIHNNMADV
YILEGDFVTAQALLDQTLNSEIIQNHKREKVAALFGYGFLYEHQHRLEEAVDYYKQAIEL
AQSYGDNPITKKVMRMLLNVLYQLDYRNEIFDVQRAYIELSEKMSADNLLQQVMNLEFNR
QKETLEKRALYDPLTGVLNRHFLDIELNDWLNEAQACHQYVGVIVLDIDYFKAYNDQYGH
LFGDMVLQLLATGLKDFLHNQEAVIIRYGGDEFIICLRHESMLFLNDSIKELHAFMLTLK
LEHEYDSYPLKVSLGACLNDQKNYEYIKLFKQADRNLYKAKNNGRANYVISAQ
>A0A1V6B3Q9|diguanylate cyclase|EC 2.7.7.65|Candidatus Aminicenantes bacterium ADurb.Bin147|TrEMBL
MRGYLLRNRVPAAAVAALLALVLPARAQVLPFEVLGLKEGIPQSQVSALAQDREGYLWVG
TWGGLARFNGAEFKSFFREDGLPSTRIQELLVASDGTLWIATVAGVSRIAGRRLEILPDQ
AVSMVRCRALAEDARKRIWVGTDDGPAVFDGETWFLFHPGSREKGPVVYDILSDREGVLV
AAANGLWRFSGDAPPDAVVSPAGLEPADFRALAVTAEGLWLGTAGAGVWLRDGADWRKIT
GSPVPRAVYSLTVQPSGTLYAATVDDGVFLKRPGASVFEHWGVENGLPSNLVSVVLEDRE
KSVWVGTDIGGLARLSNLAVINHTGNQGLPSACVFGITPGEDSDSLWLGTMRGAVHYLVR
PHPRVLETIRAADGLDNEWVWKALRTADGTLWILTDTALHFRRPGEKAVHPLPPHVSFPR
TNPYDIVLDGAGNLWGCGEWSGGGLARRDAGGTWRIWNTTVTGEPLTAVHHLARSRRGGV
WAVAKSRFFYCDGETVAPLETRCPLETGVNISSILEDSAGRLWAGNDAGLAVLEAGGRWR
LFNAKDHPGFANHHVFSIGEDWKGTIWVNTARGVFRFLSEYRVEAFTPDDGLADWETNAQ
GFFNDSRGDIWIGTVNGLSQYNPTGRIPNTEPPGLAIESVRLPGRTVEYPAGLDLAWNER
TIVCNVAVLSFRGRSRAAYRARLEGLEGDWLPLSRREELRYTNLPAGDLKLLLQPVNESG
VWGEVVTLPIRVRPPFWMTGAFRAGAVVFLLAAAFAAYRWRTLLLLRRNRELQREVGKRT
AELEYLAAYDPLTALYNRRAVLAFLERELKPERGGNRRLGCIMVDLNRFKQVNDTLGHAA
GDQVLKDMAGKIKECLRPGDALGRLGGDEFLVVLPGADGAALKSVEGRISGLACQAGEGS
AAVTVTAACGSVEVPPATNAAVAAVLAAADDLLFQVKRSRR
>A0A509CQ97|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 7297|TrEMBL
MCGTPADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMAL
YKAKNAGRNRTEVAA
>A0A1S7UCV9|diguanylate cyclase|EC 2.7.7.65|Agrobacterium salinitolerans str. Hayward 0363|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPEPGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDESILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLVYNSLAA
LIVVLTVTGALVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDSLLVAVASRISAVLGENDMVSRLGGDEFAIIQSANADCES
DAAMLAARVVHAVSRSFSLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEPGMDMAAQHKHALEIDMKSALENQEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLIAPDRFIALAEENNFIKPLGEWVLGQACMDAMTWPKDIRLAVNLSAVQLSNDDIV
PIVDRALETSGFPAERLELEVTETVMLERDNSTRILKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPSNPMCSAIVNTVIDMAEQIGLKVTAEGVENREQVEALKLS
GCDEAQGYYFAEPAPLARVLKNRAVIASIAQDEFGDLGLPTQETYCPPQKAI
>A0A2S0XK19|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MKFIPSALLLLFAATFLCVWLLERRRRHLLFFSLAFAAVGSATIVQFALWPPDIGYNTIV
SAMLYAAGPLLLVEGVLARSRRSMPLRLHAAWFAAIVGLLCYFYYVDNNLQVRVYVLNIG
MGCIILSGAWKLRDFVRGNVIDRAMVWLLLGLGLTFFVRVLLDGSSVPPDDVDAFFESAF
WIWAQFSMSLLGATLGLGLLVVACADIVLGLKAERDTDPLTGLLNRRGLQGREARLLSVA
RGKPLGIVACDIDCFKTINDRFGHAAGDVVLATFAGIMRKKLRAGDIAARTGGEEFIMVL
NCPLDQAYSLTEKLRREIASAHFAGLPADFAVTCSFGIAEFHPGEGLWDAIGRADKILYA
AKRAGRNRTFAEGLQLPSAA
>A0A3P3XJ33|diguanylate cyclase|EC 2.7.7.65|uncultured spirochete|TrEMBL
MEIDSSAIRSLFIDSSLSEFFDETDLFYIDFQSSIARSCSTLRYLGYEDADLLDILGAFP
VHEADRERVELMQKRIESGETDKVIDSFRVASKKDSRFPWLRFSIKVLGREPDGKPTALI
GHVTDVDDLIASQEEIRERLVEIDAMRELIGAINKSLDFEETFKRIIEQLHRIIPFDRAT
VQAFENDSLTVIAGYGYPKSDIMGLVFPAKGIDNPAVRAIQTQRPIVCNDVSHDFPGFIA
PSKDFTSLSWLGIPMVYEGQAIGLIALDSHLPNFYTDQHVRVATAMAEHIATAFEHARSH
QLVTVQAMTDRLTGLANRYGLEMRGTELFQKAIENDQPIGVFMLDIDHFKQVNDMYGHSY
GDMVLQQIASTIRTQIRNEDYAVRYGGEEFVVLLPGLGPRESLIVAERLRIKISQTEVEK
GRKLPTVSIGIYAAVPGSLDILHEFIRKADLALYTAKEAGRNRSRVWSTSPEFYVSE
>H1WEP7|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MMDKYLCPCCSEPLLIHIIAHKKIGFCMNCHQEMPLIEQSRQMATVTEPVDVSTINTEQL
SRDQVSRGTLQTTAAGIWILDRQTKTAFVNPKMAEILGYIPEEMIGKSLWKFMDERHPAF
SAIAHQNHPGDREEKYNLSLRHRLGKSVWVTLSVRPLFDEENQFEGNLCIAIDTSSQKVM
EDAIKKQSQREEAMERLTQVIRNSLNLERIFQMAVTELGKIFKVESVQIVQFIAQGKSWL
NRAEYRQPTNSILAKIPSNSGKTYTKQVGSELRSVLRSLTLKVPNSQDEATIQDFLQSCP
GGWLPIPLYSRSRLWGSLSLVMTDPGYQWQESDLKLIHGFANQLSIAIYQAELYHQLEES
NRKLQQLDIIDSLTGLVSRHGFNDYLSRQWQRMMEEQAPLSLILSRVEDWEQYREQQGDN
AADQCLRNVAKIIKHTVTHPHGLVARYQQAEFAVLLPSTNTRWAVRLVDTIQEQIGQLSQ
VSIYSQRLLSFGVASSTPAIGSQTQTLTMAAEQALNRGASRFCQCLLSQKD
>H1WDI3|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MINTLVYIMIITMNGKALPILDMEFEYPNDPVPLNSPFYIDHPSIEELAYREIQKPGSVI
RIRAPRKMGKSSLLQRILSYGKQNNYYIVNLDLRQTEASILSDLKRFLRWFCANVGHFLN
LPSRLDDYWDEDIGSKVSCTIYLKYLLNLIDSPLIITINEVNYLFEYPQVAGEFLPMLRS
WHEEAKQSEEMQKLRLVMVHSTEVYIPLKLNQSPFNVGLPIRLPFFTQEQVKDLAKRHGI
EDTDGNLVTSLMDMVGGHPYLVRLALYHLVVTPDNDKKSISDRLQKIISEAYTQGGIYHQ
HLCEQLAILKDQAELLQILQLIVMSNDGIIVEPIAAYKLESLGLVRLEGNQAIASCQLYR
QYFKYLYEQGIFNEYSRLHQLEAMNQELEKLANIDDLTQVSNRRFLFSYLEKQWQKHSYT
GEVISIILCDIDCFKLYNDTYGHIAGDKCLQKVAKVLQSSLHRSTDIVARYGGEELAIIL
PETTSTLAVNLAKTIGQNIKLLNIVHKNSLCADKIITLSMGVASIIPQTHINHFYLMQAA
DEALYQSKNQGRDRITAKDLTITL
>A0A290HF15|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MKKEYITILECVGHGIWEWDPISNRITLSPQWVSMLGYEYETFQQTKDMWISLIHPEDLN
YCLNELTSLLSGRIKHYRHQHRMLCQDGSYKWVLDQAKVVAYNPHGYPIKVVGTHTDIHE
LRTTVEMYKQQRK
>H1WM76|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MDQAIPPELEFSNPLGCLPCPDSPLSLDSAFYVERPPIEIIAYQQITQPGSVMRIKAPRK
MGKSSLMLRLINHANSLGYSTVLIDFQQADLGIFESSTKFFRWLCSNVTRQLGIAYNIND
YWDEDIGDKVSCTMYFEEYLIAQINRPFLLVFNEVNLLFEYPQIFMNFLPLLRFWHEKSA
QSTIWQKLRLVLVHSTEVYVSLGINQSPFNVGVLIDLPEFTHQQVGELADKYQLTLTENQ
LHKLTCLVGGHPYLIHLAFHYLYEHQTKFDDFFHRASTDAGIYKNYLKKIWILIQKKPEL
VEMIQQLITAKTALKIEPISAYYLESIGIIKSLGNNYILAGDLYRVYFSYKPISPQVPSS
IYIEQLERDNQYLSNLVYVDELTKVANRSQFQKAFKMEWECMAIKHNPLALIVCDIDYFK
LYNDTFGHLAGDVCLQKIAQAIQQNLQRPNDLLARYGGEEFVVLLPQTDGKGAMFVAAKI
CLAVKELAIASGVPKSVDSQHPVVTISIGIASIIPSSDYHPETLFMAADQALYESKKAGR
DRYTMSSEFNFKY
>A0A1V6GXU5|diguanylate cyclase|EC 2.7.7.65|Thermotogae bacterium ADurb.Bin062|TrEMBL
MKTKTVALKRFVLWWTILYCAFLVILGFFFGSYYSGLMKARTLSIVSAFPLTFDSLLKER
TDQDPHRAPRSYAYWKWDEKGSLVSSSVDQTVDGPFIPPENYDKIKLLTKNANPCLSDFV
RKPPQGPLYFYYALAEGETLTVFAFLAEEWLTRLKSLLPPVESGFVADRNGNGFYFDAKG
IEEVNSADPATYRSMGSVMVKYLGEHYFYSSASFSNLTLTRLLPFYRTIPFLFLTAIIPF
LGGLIVLWGVSHHIKRLQREQASAFRRLSQEMDRRAFGQGAAARYGPNDPATELREKIRE
IVSENAEYEKEIDRLTRKSALLSESIRDSYQSVSSVNRLLQKFAFSEDFTFPRAIDLVTN
VILSTDQAVEKAVVYLNDEIAFQKGTISIPENGSEEFSIEQGHNRIRVLLEPSKECTERD
FSIKQEVLLTFLYTTAILFQLKRETQLDPFTGLYRFEHFSRLVQVELDKAQRYRRCCSLA
MTNLRNFRIINERYGLNTSNRFLATVSKVIRENIRSGDLAGHYSGDRFLIFFQEIVKNDS
RKKMEKLKELMMQALPKDVHPGQWDFEYGIADCLEGSLSFTELVTTAYNDMAAKRE
>F4TG04|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M718|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAIEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>V6EZH5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MRLMPLLFGDVAFPEGQEYRKFQYRFACAILLTGLGISLLFLLSVEMGFADFDLRFVHAE
RAFCAISLLFYLLLRGHPQRMLVVAYVYEALAFGLYVIVFFYNGVDEMRIIWFALNLPGV
YLILGARAGAVVAIGSVTFVVTGNAHLEQPYSANAITTCVLAIVYISGFFHAFSARSISF
HHGMVEANRKLADMAAKDPLTGLYNARAYYGLCDSALHQAQRSGGSFAMLFVDLDHFKRI
NDQYGHEAGDVVLKAVAQCLRRAVRQSDIVGRIGGEEFSVLLPDTDRDGAMQLAEKLRSD
IEALMPDIGTERLRITASIGVAGRQGAAQSIADVQRLADQAMYEAKRQGRNRVTCIEEVA
A
>X5HK35|diguanylate cyclase|EC 2.7.7.65|Neorickettsia helminthoeca str. Oregon|TrEMBL
MTALILVVDDIPSNVKILEIKLTAKYYQVITASSGIEAIELAKRNQPDVILLDVMMPQMD
GFETCRRLKSDYSTMHIPVIIVTALNDMENKVEGLSAGADEFLVKPVRDFALFTRIKSLL
RFKTILDEVRLRINTKAQLTSGTENEIVSYVGDVSSGVIAVVDQQRSLFEPIEKMLKPVF
AEVIHLSEGEIEQHNFDVLIVNITLSKDLLRVCSTVKSRPKSRSIPIILIINDEDDEGVI
SEITELGISDYVDMPINRSEFIARVATQVKRKKYQDIIERSVEDNLKMAFIDPLTSLYNR
YYFEKYVDELLVTVRKSKSKTFSMMMIDIDYFKKINDAYGHLSGDLILKQLALCLKSCLR
LNDLIVKFGGEEVVVVLVDATLQEAYDAAERVRLVIEQQKFDTINEDVKVNLTVSIGVAE
YQDRDTLKTLLGRADTNLYVAKERGRNTVVMSDCRS
>A0A1Y6KZ90|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MKLRLKSSLALLMLIISVVPAAIVGGLLLKQQSDVEENYRIDMLDRLATTIKQEFDYRFS
LLSTSLDVLSRDRLFVQAINNYFLAGHVINSLGTLIKNTPLTKAAYLVDDQWNEIESYNG
IPGLNSFSKLKTVLNYRLSAKGKERLKQWVFYYNGEKLMSDKYNPTRRGVVIGVPIFRSM
TDELKHLPLGYLIVIVPIENIKKVLKPYLKDGERVVFRNHRIGDMENMADMSNIIISQGG
IDKNKPTIQKTIKIKLENKYISEPIEYTMVVYMNKYISKNPYINSLKYISLFGSVIILLA
FFSAGMTYRWIARPLEGLMATVRAYSQGEYQRYGRDLRFAEFFMVDKLIRKMAKTIQAQV
SDLAAKNAELNAACKEKEQANLQLIDFNDELERKVEEKTLALRCSLMREENRRSMLQSLL
SFSHDLQVDKNIIEVVMTQVVALYPTAGWAMKAYSHNNEAWVCENIDKNCLENNNIQPET
HYSDYYCLPKGDEYLHCFKIKNSHNEVVGMIVMQYEKLKRDDFEVISLFIRQLSTELEGR
LLNSELARIAVTDSLTGIANRKAFDHDLEQHIQLYNRYPERSFGLFMIDVNGLKRANDNY
GHSMGDALLIQTSKLLVQACRATDKVYRLGGDEFAIILEVGDEDSCAILWQRLETVREHT
NYASLPSGQCVEVHFAMGYASSEHYSIDELCLIADKSMYKDKRSFYKQRGIQR
>A0A0N0XKP3|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MGCGQCNRFEKSLCQKTDTPERSWLCPMLVAGNITRSKWPCCVTRATHPVRIACDRTGLV
KRKRTVLDRIRRLWAGLRDGERSNEEIILLSLCAISIPSILPFGIVRLLTASYAAAVVDI
GIVLSMIAVMSHVWRTGRTRLASLAISGIYSTGMVVIVYLHGISLVYWAYPTMVASFFTL
PPKRALTINLTALACMVGLLSHAHATPTLTLATFSVTVALINLFSYIVFYRTHLQVKELN
LRAERDFLTGAGNRRALQRTLMECASSSAPCSLLLLDIDHFKRINDQYGHSVGDAVLVSV
SALIHARIRANDRLFRYGGEEFLIVAKGTPAGAASCLAEDLRALVERAAMIQQQTVTVSI
GIATLRPGEPISEWVARADERLYAAKAAGRNCIQTG
>V6EX04|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MTAAMTGKSASVVLDRELLELVSSLVCLLRDGKVLFLNNAGVRMLGLSAAADAQDELFES
FVVEDYRFLMEAGWELLAEEDFLPLKLSRADGQVFEAELRVRQAPSATDIFLVEARDISK
FVKSAEALREREERLQGVLASVAEGIVTINDSGRIESANPAAERMFGFSRGQLVGRDMTD
LLPTSARERHVRFFDAYMAGLFPTLMGRQVEGMGLRQNGSMFPMEISVSELRHGRHRLFT
AILRDISERKEAEDRIRRLAHHDTLTGLPNRNLLNDRMNHALARIKRHGGHMAVLYVDLD
KFKPINDSLGHEAGDAVLREVANRLMSCVRSSDTVSRVGGDEFVVVVEEITRQGEAALVA
RKILDALEQSIPYHEHQCQVGASIGVALFPHDGTTIEEVCKAADLAMYRVKHSGRNGYCF
YSDTDGEVVAADDDRLLE
>A0A330L7Z1|diguanylate cyclase|EC 2.7.7.65|Nitrospira lenta|TrEMBL
MAILIVDDSPDDRLLLQSILSAAGYEQILVAESANHAFKLIGLDNGKQATARVDLILMDI
LMPAMSGIEACRQIKANDRFRDTPIIMVTVKTDPVELQLAFAAGAMDYVAKPVNKIELLT
RVRSVLRLVHEIDRRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAVRESTPVSLIMFDIDRFKTYNDSKGHTAGDECLKQVATAVTGAVNRPGDLVARYG
GDEFVIVLPGTGIDGAAQVAEGLRRRVEELRISHTDDVLVTVSVGYASMVPTRQTSPTDL
IKAADQALYLAKQEGRNRVKPAGLLSLVQDTRDS
>A0A5P9BDA6|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MAKLKRSEDKFVLLFENSPVGMAMIDHHSGAFLEVNDALLGYVGYSRNEFMKMSFWDITP
REYDSQEHSQIKELNECGRFGPNEKEYIRKDGSKVPIRLSGFKMTDVCGRDVVWGVIEDI
STERELEEERKKLKHLANTDHLTGLYNRQKLEKTLRFEMSRESSSLNTLSVIMIDMDHFK
TINDTLGHQAGDKVLVAVSTLLRECARNIDVVGRWGGEEFLIICPDISQKKLENLAEQIR
EGIENLEVCDDRVITASFGLAQYEDGNDINAVITRADNALYSAKKNGRNRVVLIKQ
>A0A7W6G6J3|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sediminicola|TrEMBL
MNPQVSVDPDMSDPEEPIPNQSIMVLLVDDQIMVGEAVRRALLDEAGIEFHYCSNPLDAM
AIARTVQPTVILQDLVMPSVNGLDLVRQYRADPYTRNIPIIVLSTKEEASVKSDAFRAGA
NDYLVKLPDRIELIARIRYHSAAYLSQIQRDEAYRALRKSQQELMQANFALQRLTNVDGL
TGLSNRRYFDEYFETEWRQAARERQPLSLLIIDIDHFKQFNDTYGHLAGDEVLRKVAQSV
QAAFRRPKDLVVRLGGEEFVVVLPATPMSHLAMLGQRVVDAVEALDLAHSTSPVSDRVTI
SVGGAGCQPDREDRRLALMEAADKALYEAKRSGRNRAVIDRGL
>A0A1X7AF62|diguanylate cyclase|EC 2.7.7.65|Parendozoicomonas haliclonae|TrEMBL
MKWAFQILMLVSGCLALLVYGSQSEETAWVFETNAGRFRLYGSEIEMMALDMVIALAVYN
FCIFVRALKRSYFEYFLYSLLAGLYIAAVGYEREIGQPLVILGGVFASQLILLLMVLSVI
QFQLSLLHFQFRQTLEWNPRIVSIWLVVALCVLISANIAGITLVDAGWINALVIALSGLF
ITACLYLMYKGYEHASYLVVGWLALGFGFLGQEVRGMTFFEAFDVYLQLTVPVGLVVQVI
ANSLALSAFTNERFRHYQQGYVLLENNLQREQNQRRVYNDAVRQYLHNIPSMDEQTVGTR
LLEVLNNLLPIDSSVVIAWREGKLKVISLTFSSKVIYERIVEGQDSQLENIARQGQITSL
PPSPENMSVGTINLVPVYWDSQSWILVAMQPSIGNNLKAAELQLCLDISNHACTLFMASS
NFRKLQHEADMDGLTGMYNRRAFMRESASVVHRLREDHQNFSLLYMDIDQFKILNDSYGH
AFGDHVLKQFAEVCRDNLRDRDLLARPGGEEFLALLPKADVNTAFVVAERIRKGLAELQF
TELGTGYVTVSIGVSDSATHGYDIPHLMGKADRALYRAKANGRNRTVVNDGDMTLSRL
>A0A174G8U1|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MANGLTVLMMCYLLSCRRKNRESLHTEDKVYDGIAKVNILGAVAETISFLVDGKSFIGCR
QLNYISNSLCFIGTVSMGLLWCLYVNLRIYRNFKKISEKMAVVMIPWMIEVIMVLGNLIK
PGIMFKVSADNVYQRTGGALAGYITLVIYLAYSLYMVYHSRKQGVNLSYFPVFYFVCICF
AGVLIQLVFYGVTSSWLITAVTLIFTQMQSYAENIYMDELSGLYNRRYLKAVLAKRKNTD
ANSLYGIMMDVNDFKYINDSFGHSMGDKAISTMGNILFKSIPDAGIAIRYAGDEFIVLLT
DADKACVLATINEINKNISRFNDSKAEPFELSVSMGYAEFGKDDNAEVFLRNMDDKMYEE
KRRYHGAAPSIPELNEVYDFGR
>A0A7U9FWY7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA206|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDGKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A6V8LS81|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MKAEPDDHDAPSIGLRELLRKAGIDRNDLGEGFGEGDQAYADLLYHLTRMRFSVEDSLRY
WKGIISNLEKLNAAQGRDVGLRVAICDYFQNHHPKLRSPILVERKFLLRKESDSLVDELT
GLYNRHYFKKSLHREIERFKRFQHRFSLIMLVLDDFRQIAETHGQPGCEEVLRAVARTLD
ETARDTDHIVRYDTDTFGLILPETNCDQSLAAAERLRQTLERAPVRLNDTPVTLTASLGV
ACFPEDAINAKTLLERIEKALDEAKRTGNCVFSFSGKDAGATGKAPDRNPVTATVLRVTS
RSMHCQSSTVILPGMEVDIVVPGEHPGESDTHLGCRVMRVLRRECQAAEGPCNFTMPLEV
VTAEERRVLLHGYLFNDRPG
>A0A4P7CEH8|diguanylate cyclase|EC 2.7.7.65|Saccharomonospora xinjiangensis|TrEMBL
MPLIPQDRPSPELVTSSESGADAVNRTPQTPDVSGGRPRPGARRRALLPKNWMLWTRPRH
FVVFLLTMEMLAVPGFTASFLNAPAPVASDWLEFAILALGATVHIQLTHRQEERRRNRTK
TVLIDLTAVWVFPATLVLPATLSVLLVVLIRFQRWFTARRPAHHFVFSSIAHGLAAALAN
LTYTAMSPQDWTTLTASGSLREFGLVLVTAAVYEGVQIIYVGGILALGSPSPTVRTVLGS
KTDNLLEAITTGLGAVTAVLVVIMPPAVAIMAVVTVVFNRLAEIDQLQDAVVTDPKTGLL
NMRGWTESAERALNRVRRAGSTLAVLMVDLDHFKWINDTFGHPAGDDVLAAVANALSSVT
RPADVVGRFGGEEFILLLPDADTSAAELAAERIRTTIAGLRIPTTDKRGAQATISGRTAS
IGVAVFPRHADHLDGLLQAADTAVYEAKESGRNRVSFASVPS
>A0A380PXL9|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNAASAIFSMILPSPETPAMTLPIVMITIISLSAAAY
LIFISKNYVDKLNLFSIMMGLLWAWQIILKYEYLGTNENNYLLLSLFTIFFIGTIALSDN
FLAFCLHTAPSAFTVIWLDDFHSIFRIIFTLMLPLIGFSLHHLMLRRSDEFTRKLVARLY
NEREKFSDLSMIDPLTGLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLVSSLKAADEALYRAKKNGRNKVAFAEEKLSSVESSP
>E1VB14|diguanylate cyclase|EC 2.7.7.65|Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)|TrEMBL
MRDIRYRPLTLMLAIGTLLLLGQALWFYLTGEYHRIPPPALLAPIMLVATLLAPVGGDHT
RTAAGLVLICGFLLIAVELPRSTDLASLWIGLPPVLALLLLPLAPALLLNLGLTPIWMIL
LGDPWPDIDVLLTYLSLVAVTPLVPWGQLRQRALLHDTDPQDPECRAVSRAHLQERLAGE
IDRTALLGQPLAVLLIHLPQLEIAEEQFGPKARQALLDGLCQAIAGRYRAHDILGRAEDN
VFWLVMPNTTESGAQLVRQRLSRALEPVILVETGPLEIRSGLVIRHAGEDGSAFERRLHA
ATRSLATARAPDSRRPH
>A0A4R8EVG9|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. BIGb0552|TrEMBL
MSTSLANRFRLPMAKTLRVIHLVFIFVFALTTFLFWQQGQLFSHGYRTSQLSHLESVIAR
IESKAQYKVDNLRYLKRIFIEAMDDPLFPGVATVPSEITGDVGDSPLWIRELPLPDTLTE
DSAFHGEDALQVRQQLYALRKIQGLFPLATGANELTADLYYISRDGEFIVSLSQEMNSLL
VSSYNPQVEQGSFVLASPLLNPQREPFWTRQNIAKTDDTLVNVAIPVDFRGEWIGLLGIA
FENDAVQKFLAASLPEDTQSAYQLFDERLIPLTGTVGSSNQFQLTAKHLQTIRQMLEVSS
RGTMRDGSVFITFGRVVGTRSVLISTQTLSQGLHEDFGRFSILLIAMWGIFVLFLCGSHR
VICRLVRNMGNLQREMQHHALHDDLTGALNRRGFFEKTSQISPDYVDYTLVQLDLDHFKK
VNDVYGHQVGDNVLVHATQRIQRAIRSQDILGRIGGEEFCIFLPNSDLKAGIMVATRIKW
ELESSPLLLDDGTQLQITASLGVAAYSELPECSLEQIQSLADMRMYTAKQRGRNQVCWQD
DGVSQA
>A0A4U8QAT6|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MSRKKKLDSYETKLMERILEVRFTDLEEERQLCKRLLDVSEAEQYTYGCAFANVYLVDCH
LALGEYSSCGFFLLRASTLCKDYGFDDLMLVLCNCAGLYYQKLNDDQTALSYFLDGKKLA
EKLGDISMAGKLYNNIGYSFACREDWETARTYFELAYTNIEHNLEEENIGAAVCYLTNLA
EVCGHLGDADGARQALVKCEKLCDDSVYSRIRLGCSWCAYYAMTGDREKCAEKADRLMGD
DLLNVEDQFFVCDMAEGMCANMLEIGDRERCKKLLDIIQKFEYDVSLSLLYRIQILKIKY
YQQYQEEDELGQAYQDYYIIVRKITAIEDEMRSQSMLSRIQIHQAAMEHEHMIQQRKALE
NASQLDELTGLYNRRSFNKLVTKMTHRENLKTLGYIMLDVDYFKQYNDYYGHFQGDVVLR
KVAQILSHNVMEGIYISRYGGDEFVCLCVNMDDQEVKAYIEQVTEGLKQEKIHHEKHPGS
DILTVSIGYCNETFCDGIDPDELLNLADQALYTVKAHGRNGCAGKKYQLDKND
>A0A3V2RML6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A377PKB2|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNHIFASNANMPKARPTLRSMFQRIHLMIIAITLLMAGIPLSVLSVFTLKTYAEHNLQLV
ASTISYTSAAAVVFGDKPAAQEALTLIARKEQIYEARIYDQKKDLLASWTSPTRLHMTID
DPIRKWLLPKMVVQPIMSENEVVGYVTLTAGGATMVKFLGNLMLGLLSCLVLTALLSFGL
VRRMHTGIVDELQNIAHVARSARENRAFTLRVRPSQIAEINELSRGFNSLLREMELQQAD
LVNENDQLSYKALHDPLTSLPNRSNFMSMLESMNTAQEQICVMFLDGDGFKAVNDTWGHA
AGDHVLTTIAERLRTQIRKSDLVARMGGDEFSILLRHIAHKDDVMQVIDKIVKAMRETIY
LPNGEPVFISLSIGFTLSHAQSTPVELLEKADAAMYHSKHSGGGWSIS
>A0A7W5PC32|diguanylate cyclase|EC 2.7.7.65|Halomonas campaniensis|TrEMBL
MDEFRHARLHALIYLMGALLLLGLALWSYLMGDFARILLPALLAPLMVTAALMRLGQPET
ARLSAYLVLIGGYLMIAVELPQQPDQAALWLGLPPLLTLLLLPLGPAMLLNVTLTPIWLL
LGDSQLGLDLVLAYLALVVVAGLAPWEILHQRALLQATDPVDAECSALKRAPLEARLLSE
CERAELLGQRLAVLVIHLPQLEMAGEQFGPRARQALLAALCRIVEQHSRDHDLLGRQGEA
DFWLVLPDTSDNGALLVRQRIEEALHRTVLLDTGVVETRMMISHLRPGETPDHFLQRLQA
RTQRLGDA
>L0M2K7|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium (strain FGI 57)|TrEMBL
METYLQKMKDEWAQLIGDTDPQVRLLAAEIAGEHAKVLSQEFYSVVLSDSQAADFLTNDQ
VERQLKTALQQWIIDVLSCPVEGVEQQIQVQQRVADVHARIGIPVDLVEMGFRVLKKLLF
PVIGASQHSADLKLAIYHFAINSIDLAMEVMSRAFIFSENSAAKEDENYRIFSLMENAEE
EKERQIASLLSWEMDLIYKVMLDSGPGNSLPLGQSDFGLWFNHKGRHYFSGIAEAGHISR
LIIEFDDAFRAIRHSPQGMNTRQQRVNFILQTRNTLSQIATLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHAGRAGTPMSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YEHVRTSDFVFRYGGDEFLIILTEANEADTLRIGERIRSRVEKILVSAPNGDPISLSLSI
GAAMFSGHPDYERLIQLADEALYGAKRRGRNCVELWKAS
>A0A828AIV1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNDVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTHNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDSNIESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERTVMPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A376IXS5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFAQPTWLHGLGGEEFAVLLEAASIEDAQVWAERFRQDVAATALVCGEVSISYSASMGVA
PLDVRLNSSEQVMQQADSALYQAKRQGRNQVMVANVN
>A0A7B1STM7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLLWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8B4NYT4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLTHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLSALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A485JGK2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVSIIGKSIRPDDLFARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQ
KVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A8H9MN21|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMESRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5E9SEV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMTHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGNNGPLMENIYSADTSRSAIEQDVVLHCRSCGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHAFDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIILSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0L1CBJ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6G4PH23|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGKINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIVSAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAIFDHAESVQKLRLGGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A827LEB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMESRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A765T689|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIDSLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKRKIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSNDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A377AHH3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKNVGVTIS
>A0A6G4KIP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHKGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNCHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A6D0S0P9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNRPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A827D1A7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LVDWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDDELCTNVQGNLMDEMLITIIQGHAQRLGMKTIVGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A828A875|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWNVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7B5Z658|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMSSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWHDTLTRLYNRGALFEKARPLAKLC
QTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCV
ILPGASLTQAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLA
DRRLYLAKQAGRNRVFASDNA
>A0A418TX94|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEMLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377A0A5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTSALTDYKIYLLTIRSNMDVL
TGLPGRRFLMNPLIISYATLSL
>A0A377D532|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGT
PLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEA
SENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIA
KRRGRNRVELWKASL
>A0A509EIY9|diguanylate cyclase|EC 2.7.7.65|Methylobacterium symbioticum|TrEMBL
MPQRSATGLKHAVEDNFSLFDAEEAIIGRTEVMLSRLSEVAEGVQELAGAYRRGTREQRR
LVRMSDRMQLELQRVNQRMAEQQRELQALNEALSGEIEHRTRLEAELRRLADTDHLTGAL
TRRRLLEIGERIWASGPACLLMLDLDHFKHINDGHGHAAGDAALVIFASVCQTSLRPCDA
FGRMGGEEFAAFLPETDAAAGRAVAETLRRAAAEAAVPLEMGSLSISVSVGLAASRAGET
LAAALRRADAALYAAKAGGRNRVWCPETDGA
>A0A376JG83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVA
PLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEI
TAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVSTLPTLFTRNVPTRYYGYVTQPWFIGH
SQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAI
DKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSW
ERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTSMLLLSWYVIRRMVSNMYVLQ
SSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTHQHPFSVIQVDLDHFKAINDRFGHQA
GDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILPGANLTQAAEVAERIRLKLNEKEMLI
AKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A1Q4PHU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A376RJR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLGKRRR
RKRTANSLNTFMGNRYYL
>A0A376RJC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALVRTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376YFH1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKAL
PEKGGYLCLFDVDKFKNINDTFGHLLGR
>A0A6D1DZU8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTRGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A822U3W5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLDIDNFKSINDKWGHHMGDQVIVMVTRIIKKSIRKDDILGRLGGEEFGIIIKGNSQKLL
LSIAERIRKNIEEQCSEKLLSHGPEQITVSIGCFTSKENNHSPSEMLVNADKALYQAKRT
GKNKVIIHSK
>A0A376VZ48|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWAMMWVMKRLWRLPDSYKLPCAVAM
>A0A1X7BVV1|diguanylate cyclase|EC 2.7.7.65|Roseovarius aestuarii|TrEMBL
MADSIMSDEILFKNAPVGIARVGTDGTFLQVNQRFCEILGLSEETLVCLRLHHITHPGDI
ESAALHMRRLLSEDHGRFNMAKRFIRGDGSILWTDLNVSFLQRNERQDAHFIVVIQDMTK
TRSHIDVLEHKLRHDPLTRIRNRAGFIEHLSRACRRYQRNGSSFALAYLDLDNFKEINDT
LGHVTGDILLREVATRLQRMMENDGTVARLSGDEFAVVLTNITTPEMLNAALYRLHSVFG
APFEANQAQVDISASIGLAHCPMDAHTVRGLMQHADKTMYAQKNASASDRSDEPQQRMGA
IQ
>A0A0B0VCS9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGLGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A4C9DMY5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLNFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAYNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A1D7PRA1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A377C599|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFFNCRST
>A0A2X1KKN8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQTRISTPFRRGCFLLLRH
>A0A826Z188|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENRWQDAHFDEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLSTWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQRVDTHAIAY
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVITRV
>A0A7A6Q1M0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGYEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A830V2W8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHYFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5E4U430|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MVKSLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSSMQAQLDTQVQLVAEQLDDKMR
GKFLALHRMARHLGHPDAMSLAQFDAFANMSVSMPQTFNTIFVAAPDGRMRYDSTFPATA
INIADRDYFRQVLAGAPQAASGLIAGRITRSPGIILAVPVVDAQGKTIAVIGGAINLLRQ
NFMVDLVSNAIGATGRYCVTTNENPARYVIQADVTKILSPVGPAQTLCGVRDPGPNPLLR
MHPLVARATMATTGWSVVAVLPGAEAFDPLARVRRRVILLAIAAIGLAAFAMWWMARHML
RPLDTLRDLVQRSAGDMRAVQSLPVQRADEIGALANAFRDMMEQLRDRTEALEGSREAAR
ASVRHMQEIADRVPYLVAFLDSNERFAFVNRACELRLRRPRERILGATASELLGSSLYRE
FAPHLARAFAGEAATFIWDFGDDAAFRCFEVSYQPEWAMHDVLAGVHVFVRDITVERSNE
RRWRRESHTDHLTGLLNRKGFDQALAGALRVAREGGGAQALLFVDLDRFKLVNDTWGHAL
GDELLRRLAKRLVASVRDGDVIARFGGDEFAVIMRDVQDILDVERTAMSILDATSRPMSL
SVGAVTVGACVGVAMVASGEVKTPDMMFDAADRALYDAKHGGRGRFVLGDGACVAD
>A0A1V5K9P4|diguanylate cyclase|EC 2.7.7.65|Candidatus Aerophobetes bacterium ADurb.Bin490|TrEMBL
MEKNAGFEKWLKKVNPWILIFICVLFCAFLGWLGVFVEYEFTFSTLYILPVMAAAWFGRL
RFGIAVSVLAALTWFVGDLFAGRDYSRPFIPYINTAARIVLFIAVSALVNAVRKSLEMEI
RLANEDFLTKISNSRGFFRYAEMELNRLKRYKKPFTIVYLDADNFKSVNDMHGHKAGDLL
LVEIARIIRKHIRPTDMVARLGGDEFGVILIEAGPLKAKKIAGKIYRMLGAAMKKKHNLI
TFSFGVVTFMKPARTVDDVIKKADDLMYAAKHGGKDRINYSVYG
>A0A5E4TWM3|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MALLLDAVFLVDKAGVLVYVSPACERILGYSPEELLGRSMIDFVVKEDRERTIEESKLVM
AGHPRIGFENRYIHKDGHFVHIMWSARWSEDHELRIGVARDVSAKKQAEALQRATYSISE
AAHDAADIRSLCKAVHDTLSKLFPIDAIVVATCDADLMAWEKAYQYRDSADVPLLDWPQA
RGLSTQAAQAQQTLWHRTEAVPIDGAGQSISHVRAEPFVPDALVKPGAQALAILPMHTAR
RAVGTLMLYGPASALQAESAQRLLSFVCDQTALAIERKQLIDDLYKAARFDELTGLPNRR
TFGEFASEAVRRAQRTNGKLALLFADIDGFKGVNDSLGHAVGDLLLKEIGQRMKAGVTGC
GFVARHSGDEFVAIVQDAEVVERIDVAVTRLRAEIEQVISVNDASLSVRVSVGVAVFPDD
GESMSELIRVADQRMYANKSARKSGGASFLQRLI
>A0A1S7LLX3|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MVVALLVYTSLEGSPWVHQGLHVLIEGSGAFIALFIAVVIKLLFRSGRLRGSMLWFSSAL
AVMALITAFHSTMEVNSTFIWLYSCSTMLGGLLLIGMLLPEGEQTPLYFRLMPLLAAGIA
LIIGSSAMIWPALAPQMILDNSLTPLAMGMNLVGGTGFFIIWLHLLSTVENAPYQERLLL
GNFTLLMGISAILYTLSTPWGALWWLVHLLRLLAFALILLHFFRLYTADFRLMRENDSRF
HALVESINAAVYRCEATADRRLVYASNAMTRVTGYSMEEMTAEGAFSLQRIIHEEDLEQV
EEAINGSLKSGQPYRVQYRIRHKEGKLVWINDRAQPVQNPMGGGVWFDGAVCDVTESQER
EQQLELAKRVILTVSEAIVITDAQGSILDVNPSFERITGYMRQEVLGKDPGVTKSGRHDV
AFYKKMWDQLIEEGYWQGEIWDRRKNGEVFPKWLTINAIRDKRREVTHYVGVFTDISREK
STEAQLERLAFYDPLTQLPNRVLFRDRLSHEIGLSERAGKILVLLLIDLDRFKIINDTLG
HGVGDGLLVQVSNRLVACVRKSDTVARLGGDEFGIILPGVEKPEDAAIVAETIISQLQMP
FVLEGNEAFIGGSIGIAIHPQDGENYETLTMNADAAMYKAKESGKGNYKFFTPDMNDQNA
HRLQLEADLRRAIDGNELEVYYQPKMDAQSGQIMGMEALVRWNHPERGLVSPGDFIPLAE
ETGLIVALGEYVLTQACLCVRSWWDEGLPKLRVAVNLSARQFDEENMIEKVQEVLQSTGL
PPQGLELEITESIAMHDVERAIEKVRGLRELGVRISIDDFGTGYSSLSYLKQFPLHALKI
DRSFVQDMQDEDDATIVSSIISLAKSMHLGVVAEGVENTEQLDFLKGRDCNQVQGFFFSK
PLAAEAFRQLLVSKNCAAE
>A0A1S7LHG4|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MALLESLRRLTRFNRLSREHLLMLLHPGGHSLYFNRHRAEVMVTRIRITSAAFGLLVLVW
IPLDLLLLPSPINQYLAAGRILSTLLFVYLALPYATDHNLNPVRLRLMLLFLPPTIMFVA
ASYLLGAVPLQGGAGIIMGLYILLPFIVIAGLCLFPLTIVESLFYAVSMLCLFSLGFVLN
EALSLESMISSSSILILLVGVAMLAGLMQLFYMFALIDRVSRDPLTGAFSRRSGQDMLEL
YFHIADSHERHLALVFIDLDHFKQINDNHGHEAGDEALKEAVKNLSLILREGDMVVRWGG
EEFLLVLNSTPCEGVHQIMERMFENWLGQRPDGTALTASVGIAERKQDKINHWDRLVELA
DERMYVAKKGGRARAVSCENRMLLPNS
>A0A5E4YNB3|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MPISAVFISIAVLSCVMSVAVLGSLFGTKVPGVRLWCFASALLAIVAALLLTGPSDIVVA
VSSSGLLIASLIGLHGFRQFLNARASYAWEYVALGVILVMLIYWTFLSPHVDARSTMISG
CIAYVRFSIGGAVLKYRPRERPKYAYYFVAIAAILGAVVHAVRSIAYGLGLAHESTFLQP
TPLNVMFLGMATLTLPCLSVGMVLLAHDRLADRMERLATFDDLTGLLARRAFIARAEAIA
RECAHKHSTFSIAILDIDNFKSINDRYGHAAGDLALAHVASLIAGAVRATDIVGRIGGEE
FALLLPGETREHAGHLINRLRDIVATSGSCVPGREVMSTLSAGVDAFRDGDTLASVMARA
DAALYAAKAKGRNCVVVAPAMEPLPIVVEHGNGAGVGGKTAVG
>A0A1R3TXK1|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MAEISRADIRSRIGVVLWLLNPVIDAPKEARTLLLGQLLSSPLAIIMGSVNSSLVTAIGF
FRHDGNIFAVFVTLELLMLTLRLMVMRYISHVKAAGKLPFVDLSILFSILWCALQGSFAF
FIMQTGDTVLMVLSATLIMGIIGPICARNFSAPRLALLLVCLCDLPFKTGAVLSGDPWLF
ALVIMTPPFFLGAMQVILTFQKSLISTLQAEIRNNFLANHDALTGLLNRQGLDAALAGLL
ENNSRVAILGADLDGFKQANDEFGHLVGDKLLREVGVRLANSVRAGDLVARIGGDEFLIV
IKGLPPEDVMHITERLIASVAEEPIEIDGIVVKVGVSIGYSCYPEDAKEIEQLRLFADSA
LYSVKRAVKGIAHRFIAFGETTGRPRIAETTDLVIEPTL
>A0A2J7Y3A7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MHHSTGKRGVSYDPSQRRQRRDIPSIVRRVTLGVVVVWLALVASLSGWVAQRLTAEELDN
LAAGAEYEAQITGRVVDRLFTEMASVANMVARQSEVIQLAARYRHDPPGFAALTREERAS
KFTRDPLVRSVGDFMDRLASDLHYARIYMNNLSDDTVTASNWAESFSIVGQIYTGRAYLL
DALRTGSGEMFGIARLNKTPSYFVASPIDDADGKPLGSVTVKFDAPDIALYLTGRHIALI
VNRQGRVTTASSEPFMLRNVASLLPPDIRRPLDGDEEPGEPMDIRAVAAAAQADQWLIGG
HPYLVHRQPLNDAQYQLLTLAKLDHLQPMRQQYYWTGASVAALGLILILLSSRVAGQMLL
RRQEERYAANYDALTGLKNRRAILAALHRHFALAKRTGQGVLVAFIDLDEFKAINDTYGH
EVGDKFLIEGSRRLQGGLRATDELGRWGGDEFVVIGLTASVHPDEMAKTAAAMRRRLVPL
LIGSYEFDDCRFDYAGASFGITSVDPAATSLQAALKAADQLMYADKEVRRGLRRV
>A0A7V8QD26|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MNELLNVNEQRDNGEPDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQAAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLRDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRGHSTTTLLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKKIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDRPIYL
QNGECVTMTISAGIAVYSGHPDYECLIKAADDALYQAKASGRNRIEYAPEE
>A0A1S7T4V8|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum CFBP 5771|TrEMBL
MLFSICCCVRKKARLAASLIGCWLPPLQRGSASGLRISLPCLLIRVQSRSALISSSPALS
AVLAVLGFWLALRARSQASYSPVIVGTLVTLSVAVMHFVGMAGMDVAATISYRWGPVFGG
FAVAWVFFLLAFFLFLRSAAWKRIVIPAGCSILAICALHFTAMSATILSPDPSVAGPDPD
NLARVIMIAAVSGVTFLVLAATATAALVDRYLVDLKGLVDATLDGLAVVRDGRIVELNTR
FAGLVGSDEASLMGKNPDDLFKAMDGQPTYLPRLAPVEAIRERSDRPQVFELAVRTIEYR
GHPCEVLAIRDLTEKREAQREIEYLARHDVLTGLSNRTMFQTRLHQQIEHCDAEDEFALL
ALDLDRFKAVNDIFGHAEGDRVLKKVATILDECARPGDIVARLGGDEFVILTARHTKSEE
ARLLAETILAMFGLKMNAANDPTAVGVSIGIAVFPRDGNSNESILHAADLALYRAKMGGR
GILSFYDPLMDQEARERRQLETDLRLAINRNELVLNYQPVLSVECGQVVGYEALVRWQHP
TRGVVPPDVFIPIAEESGIIISLGEWVLREACRQASTWAPHLKIAVNVSPLQFSLANLGH
VVCTVLMQSGLSPNRLELEITEAALLKDRKATLIILNQLKALGVAIVMDDFGTGYSSLSN
LQSFPFDKIKIDRSFIAAMSEDDNARAIVRAVIGLGRSLDLPVTAEGIETDAQYRMVVDE
GCAQAQGYLFGRPDVAPAAAASTGKRKKHSV
>A0A5B9QMV3|diguanylate cyclase|EC 2.7.7.65|Roseimaritima ulvae|TrEMBL
MAMWSATVLLGLRLAGELNDGDQQLLASRTMLSESVAVSCSQMISRHDYVGLQVVLESLV
SRNPDVLSAKASPTTDPQQGASSPFAEVVVGPHAEVWNREASQATSTQIAVPVLDGGHPC
GRIQVAFRPPVGQGMLGFLALPSIRVTLFATLINFLGFSIWLRRCFQHLDPAKAVPYRVR
SALDTMAESLLVLDRQGRIMMANAAFAKICDQPADRLQGKSFDSLDWEFADGVQRPSTKW
LRETADATSEGDLPGIRLRDAGGRLRHFKVNASSVLAEDGKPRGILMSLDDVTAIEEKNQ
ALQEALGHLEQSQAEVQEQNERLTFLATRDPMTSCLNRRSFFDLFNEQWKSMQRYKHPLS
CVMVDVDHFKSINDNHGHQTGDEVLKAVAAALLETARDTDYVCRYGGEEFCILLPHVDLE
GAKQAAERIRVAIENLEVQSLKITASLGCSDSQQGGETPDQMIDQADQCLYYAKRNGRNQ
VAGFDVIQQAEPEQQVLEQVQQIQEDVDSAGVEVAPQNESAAESESEHAQSI
>A0A433N728|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQAAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRAHSTTTLLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A8B4N8Q8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter nosocomialis|TrEMBL
MPYSLREFSFSSSLKFFFLFTLIISICCFIGIASRPLSFLAFFWPANSVFLGLLIRFPQT
RQVGSFVGAFIGYMIADLIKGTPLFLTLILTASNYLYVVMTLALAMLFGRYIKAAYRGYS
YLVLFALCGIGSITGAFFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNF
PPYLKIKNYIKGNQVYVKAVDFLPLLAVLISIAVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLSNTISIRIGLIMMTIAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKEHKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTKEAAFELAERIRIKISQQPI
YVYGKLPIFVQVSIGISLYSPNYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A238JP09|diguanylate cyclase|EC 2.7.7.65|Octadecabacter ascidiaceicola|TrEMBL
MTKSEPIDGGVPVSKRVSWRDTENSNDAGVLLATQIMNVMEQGIIVWSADGTCELHNTRI
YEVLELERNALGIGTIRDDFLAAAVTRGEYTEEKLSELRAFAKTRISYQYDRMLPSGGVV
ECHARPTREGGYVVTCTNVTEARKAAEELAEAKKAAEAAESKSSMILQEERARRAEARTL
SDLDEWLQSCKSLDELFKIVARFMGYLLPDSFGELYLYSNSRDVLDGACEWGQQDEINSH
ITPDSCWSLRRGRAYEHNPDALCFPCDHLSSSSKETPGDYICIPVIAHGDTVGLLHINFK
KGMSRADIKSSGRFAARCGEHISMAIANVKLRDELHDQSIRDPLTGLYNRRYFMDAMRRE
TSIADRGGKGFGLISLDADKFKTFNDNHGHEAGDVVLRALAERMLAVLPNSAVCARVGGE
EFAVLLPQTDEDESMKLAETLRASVSQMEVRTAYGILPRVTISSGVAAYCGDSTAPSVLM
KRADVALYDAKSDGRDCVRLAKIDTREAVTPMHS
>A0A3P5XB75|diguanylate cyclase|EC 2.7.7.65|Xinfangfangia humi|TrEMBL
MGHEPSPPRAEQEAGLALDPAMLARLMPMHLILSGDGTIRAAGPLIRRMFPGTEIRGRSL
FSLFALRGPSQITCVAGLIARDGQKFRMVPQGGGLRLRGVAVPLARDAGVLVNLTFGIDI
MRAVDQLDLTDTDFAATDMTMELLYLAEANALVMGEMRALSRRLEGARRQAEDEALTDPL
TGLRNRRACDAFLAGLCREGTAFALLHLDLDFFKQVNDHHGHAAGDQVLTAVAAILRGQT
RTRDCVARVGGDEFIAVLPELTNETRLRALAQEVVGQISRPVPYRDTLCRVSASVGMVTV
PPGLYPDPAQVLADADAALYAAKGAGRGRVAWAQDLGLGPGAGRSRGGNADEAGLDARE
>A0A377HR16|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MINSLNPILNMGITRCDKLQVHHLRMVNLLACLCTGGTLLFSALFWFAFGSATAALLNGL
FAVLYIITFVLTREGILWIAKYWIFIIFFLQQLFLPLFVLSDNFETELLLLVVPTAVVLV
FDPKARFPRYGLSLIAIFLLFLAKTLPASDPVLGLTGTNAQAAYLCVILILVLASVALTD
FYLVDLHNIDEQSRKLVHEDLLTGTANSQSLYNQADELFFQSRRRNTPLSIIAINLDDFS
QINEMHGRQTGDQVLIHIADLLREQLPAETPIGRLHADTFVVLLENSPANKAMNVAEQIK
LAIGRSVLLLDNTAVKRTASLGVTTSSDACISGAKLVDTANTAVNHAKKRGKNKIQALLP
KNFTCFYRNESYPPS
>A0A1R3TAK3|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MTERLREFISLEVSLTDLGEGQDLRGFTTKMVFISIILSLLVSGIVIAVANSLNLLPLPL
LEALMYSVAMAWIVGGAVTGILCWVVAGAIRKLHASHAEFERLSRTDTLSGLANRRAFNQ
CFDEVESDASLAIFDLDRFKGINDNHGHAAGDVVIKRAAAAIEDVFGEFHCVARLGGEEF
AVIVRGGIRKDRLTLIELARIRVSCLTINYNGTQLQTTVSVGVADIDPSRSKHDTFAVAD
KALYLAKASGRNCVCHEDELCVAQAVENLKSTLLAAS
>A0A1F2PII3|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKQTVLIINIATILVTLFLVFVSYRHRSEKGGLPFLCSMALLLLWVAGSTISMFTQSYEE
KVFWRNFIQIGMAFIPLANLWFVIEYTENKNRFLKYLVWLAAFLSLAGIVLTFTNPSHDL
IRKSVEFVEINGQWDLVVELTFLGNMFVLLRFALMFASIVILMLFQIRIVKSGQKQVFYI
LIGFTLALVLLIVKNYLMTGYEEVFPMSVIFLIPNLFIAYSVYRYDFLKIAPLAKDWIIN
SLPDGIVVLSAAGEIVEVNQSAERFFGQLTEKEAPPGHKKSALQNRNRYDYSEYTAFLQA
QPLWQKALDERKNGTLEIELENDSGDSLYYEIDQHHFISDRNHYSGSVSVIRNVTNFRLE
KLMLKRQAEMDRHIQILNKHAYIDYVNAASSVQAAFMVIDIDKFKAVNDRYGHPVGDVVI
LKVVEAIKQCIRKDDLIGRIGGDEFSLTLMDCGKKRTQAIIQHILMMVQKETADILEERV
TISIGVVTNQKLPDCSFATLYQKADEALYGAKKAGRNQVVFYDDQPC
>A0A0J6EY63|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MDPLISQLAASLPAAKTLEQLTRPLLDMLGVVTGMESTYLTSIDLQRNVQQVRYARNEGA
MEIPEGLEVDWSDTLCRRALDEGCQYTADVGQRWGDSDAARALGIQTYLSAPVRAEDGRL
LGTICAASAAVKPLSAEARAAITLFSSLVAGFIEREMLMRELQDANQSLRDVALRDALTG
LPNRRALYETLDMALARAAASGDTVLVGLMDLDGFKQINDTHGHQTGDALLCALGRRVAG
ALRPGDVLGRLGGDEFMLVAPGPADRAQADEAADMLQRRMQAESVGEYALGGLRLAYGGA
SVGVAVVSPGADADHAVLLADARMYEAKRVRRVRPQGNSGVA
>A0A8G0TN04|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MYLAELMARPQSEKGKILIVDDQPLNIKILHQLFNEEYELFMATNGEQAIAICQKVQPDL
VLLDIEMPGMSGFDVCQHLKADPETASIGVIFVTAHFDEVQEVKGFQLGAVDFIHKPINP
IITTARVKNQFTLKRQSDLLHSIALLDSLTGVANRRQFEQRLPELWKHCCRNQLALSVVM
LDVDFFKRFNDRYGHQEGDQCLRQVAKAISDSLRRGIDFVARYGGEEFICILPETPLSGA
MNMAKNIVNAVQALHLEHVDSSFKEVTISAGVSSVIPRQDLTWQSLIETADQQLYLAKER
GRNQIASLSL
>A0A8F6CJL1|diguanylate cyclase|EC 2.7.7.65|Methylococcus capsulatus|TrEMBL
MKSPSAGAPDRHASSRSVPDRWNMHKPMLCDSLPTASRTAAAILNLAQREDVTAEALAQL
IQTDPALTGRILRFANAPAQGTRRPVASVIDAIDLVGLPAVRQFALSLSLIDAHREGRCE
AFDYAAYWQKSLARAVALQSITAQASTVAPKEAFTLGLLADVGRLALATAWPEEYSECLR
KADGEALIALERERFATDHDELTRMLLTDWGFPQVFIDALQLSQQDEIRDEGRTGRFARQ
LALAQHIADHRLAEEPRRAALSPLLRAEARRCGLGDEDLARLLADPPADWLDWTRTIGLP
GDAPTGGAEPSRPPPQTDEKLHVLLADDDPIMLARLSRQLEADGHHVASRRDGETALAYA
LEHQPEMVITDWHMKPMNGLELCRALRESALGGNVYIVMLTASESEDALVEAFGAGIDDY
VIKPPSVRVLKARIRAGQRIITLHKKLARERKEIERYSSELAAANRRLELMAHTDQLTGL
PNRRYAMDRLEREWAQARTFGRPLSIMMLDLDWFKSINDSLGHDAGDQALVHAARVMRET
VRTSDVVCRMGGEEFLIIIPDTVGPAAIQTAERVRSAVEQQQPAKLKLSRPLTASIGVAD
STSAPSLKDLLLKADNALYQVKQNGRNGVRYAGL
>A0A087EBR8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium subtile|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYAVSAAATGEEGLLLFTRGGIDLVLLDLMLPGIDG
VELCRRIREQSRVPIIMVTAKSAEIDTVVGLEIGADDYVTKPYSFRELLARIHAVLRRNQ
IDEEDAQAHDDGVTLRCGEVAMHVGKHEVTVRGEQTFFPLKEFELLQYLMQNKGRVMTRH
QLIDRVWGSDYVGDTKTLDVHVKRIRSKIEEDPAHPRYLTTVRGLGYKLSDEDR
>A0A3S4NDK8|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MGCRYWVLLLCLCSPLSGNAERLASTYLNAAEDANHATQLVRYCVDPDWLPYEAIRDGQH
VGISSDYIRYIEAHSSLKFSLVPTTSWTQTLHFLQTGRCDLTPLLNKTVTREQFLHFSHV
YFRSPNVLVSLKEQPFLQGFENIGSRTLAVPDGYRLAEYIQHYYPNVHTIKVASEPAGLE
AVLEKKVDLFVGSMFSVNAYIHQTGFNHLKIAGWGGPEDELRVGVSLGHEALLPIINQVL
DNVDELERIRIYQKWNNITIIDETNYLLIYQVIAGTLLVIFLLATRTYVISRYNRRLTDK
NQQLEVLRLQLEQSNAELEFLSTHDPLTKLYNRHYFNRQFVHEHRAAVSMEGTICLVMLD
IDFFKEINDTLGHAIGDKILMELSSVLQHCVRESDVVARWGGEEFVILCHNTSLEAVKSL
CQRITTAISEYHFSGDVQLTCSFGIAKLAANEPMQSCFERADKALYQAKALGRDQICVDD
THL
>A0A6S6XYE4|diguanylate cyclase|EC 2.7.7.65|Denitratisoma oestradiolicum|TrEMBL
MLPGRKIPGHLAASIGLPMGMTPTFLTGRRLGLRGQHTLYAVALSAAMVLILIGISYIGA
KDLVQQSAQLQLHEAAETIATPMAQALDVAGRELKTLARERLFTSALLDVPGRNAYLLPY
LARHELPTDIDYNLALADFHGDILAARKTRPGYRDQPWFRTMLDRGRPYSGIEMRKGSAT
LYLAVPILYGRQGHYEGALVMDSDLSAWLSPEQDALPRSLGIASMELIAADQVLARQVMS
TPPQVVSVAIPIKAPGLTLDPPLELRVSMDQTLFERPLDKLFIKHISVGLLAILAAAVIS
GMVARTQTRRIEMLAQEARNIALNGRSSISLTDGHFGNDEVSDLANSLSNLLHKLNSRSK
NLEIQVEQRTAELNRAQHIAKIGIWSIDLPTHTMVWSPETYRILGALPDDQATLESFLAC
VAPDDRKRVDEALQTALVTGRFDIEHRIMAPGIRRHVHSVGEVTYSRKGKPLRAVGTSRE
VTAEREAARALIDSEAYNKALFEGSQIPLVIMDPVSGRVVDCNSAAAQIHGMAGPEALIG
MAMLGLSAPVQYDGTPSTTAMARHVAAALETGAVLFEWRHQRPSGEPWDAEIRLMRFRHK
ERPLLQLGLQDISERKRTEARMIEALVVFKASNQGIMTIDDQGLIVSVNPAFCAITGYTA
EEAIGRKASSLNAPPPHQDAGVYQITNQSLEAKGSWEGEIWSQRKNGEIYPQWLSISAVH
EEKTGQVFEYVALFSDISERKKQQEEVWRQANFDALTGLANRNLLQDRLTQALAHARRNG
SKVGLLFLDLDGFKWINDTLGHDVGDELLVEVSHRLQATVRQEDTVARLGGDEFTMVIQH
LDRQDSLENIGEKIVTALRRPFGLASGVQHISGSVGIATYPDDAADASTLMRYADIAMYH
AKQAGRNRVQCFSEHMQADALVRRMEAERRVALDARGRSV
>A0A7W5PX13|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK312|TrEMBL
MPPQLIYRGALRRLGIAMEVETHLISLIRVLGQVAIIVYAYSWVIRIVERGALKSVAVGL
LFGLVGILSMGDPIQWMPGVIQDGRSILLVLTPIYGGLLGTIVAAAMMALFRYMVGGMGA
VVGVAGIVIVAIAGYVLTLLPRQWTGTGWRRSALFGLATCSSIVVVFLFPWAVARALLIS
ATLPVTIVNILGVMLLSDLLQREQYRIGIQRALENEASLDPLTRLPNRRVLQREGDRCSK
EAGMRRIPFSIIMLDIDHFKKINDSWGHSFGDTVLARLADVIRQTVRKTDIAARYGGEEI
VVLLPNTDTRAAAAVAEKIRKDIEDTTLMFEQEAVHVTVSIGIACSLEPTTDFKHVLEAA
DKALYRAKAGGRNRVELAEAV
>A0A6N3AWF8|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MNETLRANMEKLNRAVFRDELTSLYNRRFVVEKLAQDLMEEGREDALVMADVDNFKHIND
TYGHSVGDMVLVGIANIMESICRRHKVIRWGGEEFLLVLMAVTKRGVLEICEEIRREISA
FPFMCGDVDFSCTVTLGVEMYDKQKSFDENIVCADKALYLGKTSGKNRVVMYGSENETGE
>A0A1S8PLG9|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MSKSFTFKLYLIFSIIAILMPTLFIILVQQKIIISFEKWEISNFIYFMFTIILLLAIIVN
KIIRAYIKLKQMKSNLNIGDRKYSNDVKLIDGESLFNEIDKINRSIRILKFENSILYDTA
FAIYNMASIQELLDTILARLVTHTNADFGLIFLLEKDELKLKSHSNVLYEELEKTTFRIG
EGLVGWTFYKGQGLLTDDVQKDFRYIRCISDTRAQITIPIKMHEKILGVLVLGSKKDSDF
GESDFKLISTISGEIGLAINNAKLTAKLQKENQNNQRLFELTKRITSSMDLEEVSNMGIK
IVTEIIEVHSCTLGIFDKVDENKISVISSYGDDKKGLEFSGTVEEAFKKKHMAEIKTDKG
YIYSIPLLSKESCMGILHINTKNKLTIEEIELINGTITPLTSALENAFLYKNVERLATRD
GLTGVYNHRYFQDMLDEYIIKVQKDENDLSMAMIDIDNFKKYNDTYGHPVGDLLLKKVVE
VMRSILRDEDVIFRYGGDEFTIILPYTNSEDAGAIMEQIKNIISDYKFEIGDKEEEETAL
DLELIKESTFKSEKLFNSNIFKKWISEKVGLSKSKLISNTFNITISVGISSLVDVNYDKE
MLIKNADKASLKSKRNGKNQVTIWKPELNMD
>A0A3S5DPX9|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MIDNLIERISTALDAEYTLEGLVRQLLEMLELVTNMESTYLTRIDAEGSQQQIVFSRNTK
TMNIPEGLTVPWEDTLCKRALDEGRRYTCNVASVWGDSEAAKALGIVTYVSTPVTLADGS
LYGTLCAASSEQRILTDHSEQVLQLFSQLIAQQIQNEQLMKKLQQANVALTAASYTDELT
GLPNRRAVFDQLPRLFSRAKDDARYVLVAFADLDGFKQINDVHGHETGDDFLCAVGKRLK
EEARGDEVVGRLGGDEFIVAGGGPAEYSEALRAATAFRTRLSALLSGKYQLKSCVIDYEG
PSIGVVAINPATTTPDGALREADTLMYVDKKRRKNGAAVS
>A0A1S8PJ66|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MEPVNVRKKVDILITILIAYFFVLCLSYKVFELDNSFENYIMLEVVMIIALVSYYTNVTL
ALVVTLAADFVYMSYKLYLNFLGNINIDFYSYYWIFLIPSTAILMSLVSRNIFALQTENE
SLINENSELVMIDEETNIKNQRALLIELPIYMKLSTRHKIPVTLLIVKIKFAEKLRSILG
KEGYKLLLIQASQVLEKSLREEDIKYIIDDKTFGFLTITDISGAKVVKERFRENINKYDF
TKGSHYKKVKLDIQIGSYTFDNSIKDPLEFIRLAEKELEYDIYE
>A0A1S8Q1H7|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKNISIKLKEVNFTALTGIIIISIILLTNFVKVLKYSYFELIDADKYVNLSNNVEYFIP
KDNQYTEINQVADNSNIKFEKNNSKNIYFPEDVQKVWLKLKLQDKQASTDNIMYIDCEFI
ENIQFYIPTTDGKYVTERPNEYFIFPYINLPENTDFNKDIYINSTWDSNVFNLLLAKDSN
FYTIENLLSCFYIGNLGVLLGMLIMNMILFFSSKDKKYLFHSLFTGSLLSLLYCLSGMQK
LILGFNSNNRLIALGAMAASTWVLFIYSYLDIKGHMPILNNFFKLSILFLVLSLYISEII
PGGFTYDILYLQMILVGLYILISIYSYFKFGMGSIYYLVGIFILFTGFIVYILGSYGLLE
WNIFTFSTCYPAASIETLLFTIGIINQIKHEKEVNTKLQLDVITDKLTNIYNRRYFEETV
VNKILQLEKEKSLVSMLVLDIDHFKKVNDTYGHSTGDLVLSETAMIIKQCLRKEDILVRW
GGEEFVAVLPFTDSKESTIIAETIRLSIENHRFKFVNKITVSIGIAEKDIVEDFHSWFRR
ADNALYNAKENGRNTVCVCYTNEIKNNS
>A0A447V0H8|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MYGNAFERFLTRYKRPQRVVNLCFIVVFLCSTLLTWREVAVLESAYIANQRNGLDSIATA
LDRQLQHSIDNLLFYRNTMHYALQSPISTDISRKALANFAIQRTQPYWQLQMDLNRGMPV
NGVSDEFVSHRALLDRDERWIYPELEATLEFSYIMQLVDEKRDLQRRIFYTSRAGFFLSS
TPRENDPAIISLYSRLITRPYFVAQSPENNPGRGLRWIHTYNPDSLNGQVITASVPLDLN
NRWYGVLGMDFPINAMHEFLQELSHERYEGTVMLFDRQFTLIATAADRMPLAQMFNARQQ
AEIARSMESGEEGELRMDTRFVTWAKLTNFDGVLIKVHTLGEGVQGEFGRISIVLTVLWL
LFTLMLFISWRIIRRLVSNMLTLQQTLSWRANYDPLTRLYSRGAFFDIAHGLAQQCQQED
KPFSVIQMDLDFFKGINDRYGHHAGDKVLAHTAALLSSALREEDVAGRVGGEEFCVLLPG
TDLTAAAGVAERIRCRISSRELIVSGGQTLRVSASLGVSCAHERHDYDFEHLQSVADRRL
YRAKQNGRNQVCTRD
>F4NG07|diguanylate cyclase|EC 2.7.7.65|Escherichia coli D9|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7X3M4L6|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. Taur|TrEMBL
MTLEILTSQDRPQRKWLNALFLGALAFLLTLFCLELIVVSGRISPLWYSTALMTVVVFRA
PSKHVPLLLLSCVIGTSLANLIVIGPALSNLKFAILNMVQAILGGLMLRALLDRRNPLNS
LLDWVRFAVCAGLIAPLIGGVVAVWMLQVGHRASLPFFSTWVISEVIGVLAFGPVLLLWP
NKPLRQLITPGRQLETLMTLIVTLLASYLSLRFLPWPFTFIVVILFWCAVRLPKFEAFLL
FFLNASFISILLAFSFVNLAQTGLLLGQVSTWLPFLLVLLPSHVMALVMDAFQREKHHIS
ESETRFRHAMEYSAIGMALVSPNGGWQQVNQSLCHTLGFPADELKKLTFQQITHPDDLNS
DLQQLERLVAGDIMSYTMEKRYFRKDGEIVWASLTASMVRDANFQPLYFIAQIVDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYELFALGPHQVPTYDVWLHL
LDPAERETAALTVQQAIERRSAFHMEYRVNLPSGSRYVRTEANRILSQDGQIERMLGICQ
DITPLRALNEALFQEKERMAITLASIGEGVISTDDEMRVTFMNPVAETLSGWTQDKAAGM
PITELLNITRGAKGPRVENLLLCNLSGERTTPDLEEGLVLHTPDGTKVEIHYSITPLKTL
TGASIGAVMVIQDVSESRKMMKRLSYSASHDMLTRLPNRHSFEQQLKRMVNDAAANHSQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELAELMQKHLRSSDLLARLGGDEFGVLLPNSDV
DQVRDVVQRIVTSVNEYTFLWHDHPYHVGASAGITQIDQNNCISNVVMSQADVACYSAKH
AGRGQYHVYQEVQM
>A0A021X1U6|diguanylate cyclase|EC 2.7.7.65|Shinella sp. DD12|TrEMBL
MMDAKTIFTTASVMVLANGAILAAIHRDLPARLRGAASQWCLGTLLVAFGCIVFAFGAPL
PRPVMLSAANAAFAFGLTAYYAAILSFHRLEMRVWHFLPATIATLSVVWFSTVMPDFRIR
ILIVSAAWIWLMALCVRVLLDRTRGHASLARSILAAMFIGVGAYSALRGALYLRVGVPDA
FAVETGDNWLNVLSAMLLTLLPVMGTTAFLLMCSDRLRRGLERAAATDYLTGLPNRRSLA
GRAAEAFLAAKPRGRDFSIAVFDIDKFKAINDTYGHETGDRVLIHVARRLRAEIRPTDTI
ARMGGEEFAVLFPDLGTDDAFAIAERMRAAVEGSDFTVGDARIDITISGGIAVLRPGDTI
YDDILRRADSALYRAKSNGRNRVEIAGEAGPDSAVKARMVISPPPAISAAGSAIAHTTRQ
SAHP
>A0A8B4DYL4|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQ
FSDTGPRSMIGRVIVGLCAVGSLGWALRWVVGPWPSLREAVAFVAFADIGIAVACWQDSD
PLAGLVGTVLFTPVGAYVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVK
VTSMLLVVVLIPAVIQFGIAVVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPL
DGDQVTAVAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTSGTTGTSVVGRSGGEEFLVV
TVCPASAVAEFAARLRQAVTASMPAGIAVTASVGVAAQAVSRVVSATPQEAIEVLTACAD
RAMYEAKHDGGDQSRILHADHDSEGRYLWRSGA
>Q8EAN9|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MLSYPRYLAVFLLIIGQSCLAFAEEQPQVGQLFKLFDSGESMPRATIEQNIALLEKLISS
DDIERIEKLNQIKCWNQASDTEEEIAKALNYAEQALSQIPSTASTHFITDINLCRAWFLQ
LTGDINGAMEGYTKSVQSAYEHEDIKLIADARSLRGALYSYTGDFSEALDDLVTAQGLYE
SLNLTGWANINLTDIATSFRRYGDPESAIKYYKKLKELYLKNGNKEQVANVMSEIGIALD
EMGKHEQAIEHFRFSYQYFKDQKLNIVAAINATNIAYSLIQLNRLDEAENYLNEAAPDIS
ENEPAAYSFMKLFMGKIRNQQGRYQEALDELSAAEHAFRVMHNDRGLIQLLQLKSDIYAA
MEDLPQAYHILQEFIALTKKVDDSSIAHQTTELKVKFDTSWIESENKRLIDNQKLKEQEL
TLLEKNKSLQLIILLLTGCILATVSLFAYKQVHRNRQLQTIALTDYLTQLPNRRHIYAQA
EQYFQLALKQQIPFSIIIFDADHFKKINDNFGHEIGDQALLTIAEASKTLTTDRNLVGRI
GGEEFLILLPNTDADRAWKLAHELQTLITRFGAINLPVELKLTVSAGVATLPIQSELQDQ
NFARLLKRADNALYEAKNAGRNCVKAAEITG
>A0A0D8FU86|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MPRGHVTSVVRPFIRADQDTLLGLLSVGGAIACSLAALSPMSVHAPVGLNFSIGVTNALL
GIAILRWRLGSRSLFQVSILFFMVFELSVLITATHTQIGLATDLVALPWIAVYAACFATA
RSFFTLATVMTVAVITATALSSVSDPWFTTIRILLITWCASVALHIFIVALRRRAETDGL
TQILNRNGFFRMAVATGVQRSIQSTFVVLLDLDGFKTINDQHGHIEGDEILRQTAKILKQ
HLPTKTILARIGGDEFAIVAVATESEVLLKQLQRLQSATPCTFSFGLVPWTDSSSLDEAM
VLADEALYVDKRNHRSRFGESATECQPE
>A0A1M9P855|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MRHRALIITTVGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
LGPHGLWPRLIHGVLVASALVVGLCWVVLPWPRRRVAIAFVWWADISMVVGACTLSAPAS
RLGALAHMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLMGWNVRLGEATWFDQYVYSAPA
LSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPLTGLLNRRGVQVALSSLLSGQRATRIV
AVVLVDVDELKELNDRLGHDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFDHA
DEATGLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGAKIERRN
GFHAVP
>A0A0T9QUP0|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MALHPASFDDHLFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYKAEEVIGQSFELF
YTPEDLANDLPAKGLSHTNQFGHYENQGWRVRKNGKRFWGHLTLSALHDSDHNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDINGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDNG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVTTWNHGAERN
IGYASNEIISQHFGCFFLPEDIAAGLPEKLLKTSASTSRVEREGWLVRKDMTRFWAVTII
TVVHDHSGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEEIFILWSPLQDKNQLVAISQCLTQGRHTLLPE
GSQLLSSQGERQEIRCSISPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAITQLGKDEQHVLCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLLNCPNKSATEVLERVVADIASIQFHWHGQSYSFTASLGAVSL
TQKTETAAQAMRQADIACYAAKHSGRNRLSLAL
>A0A6A7SKL0|diguanylate cyclase|EC 2.7.7.65|wastewater metagenome|TrEMBL
MVLFDIDWFKSVNDRFGHPVGDRTLIELTHRVAAILREADQFGRWGGEEFLVLAAHTDLR
GATVLAERIRRAVADTPFPGVGPVSVSLGVAEMRFGWTLAMLTERADAALYEAKAMGRDR
VVVAPA
>A0A0T9LW46|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MLRSMISTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNTLEANRVYAAK
LASSTEIFLRSAQKQLHYSSMIAAKHFDDQAVLKAETARLKYQTDSFNSVVITDAHGIIR
ATSPDSLQLLGHNLTSPGSAEALKLRRPIISKPYVSAANNLVINISTPIITPDGRYRGYI
GGTIYLRKQSILNELLGEHYYRDGSYIVVLDGDRRILYHRDVNRIGEILEPKPITEAAKK
SDNGSLMVTSSNGESMLAGYAVVDQSGWEIITLRPESSTLKPLEGLMLKGLAHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIASSIKEIPSWYFEATQLKRALLIGISLLQ
KKIGKLRFEAHTDPMTGLYNRRGLATTLEPIAQLGQHFSVIALDIDHFKSINDSYGHDVG
DEVIKQLAIQIRDSSRDSDILCRSGGEEFLMLLPGTVPDVAIQVANRLRHNVEMMVMPGI
RPITISLGVAFWNGVGTPEDALKRADEALYRAKQQGRNWVEVA
>A0A837Z6U4|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLTTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>A0A5E4SKW8|diguanylate cyclase|EC 2.7.7.65|Pandoraea commovens|TrEMBL
MSHTLPPRRATDRTDSLYSSDRPAQTAHALWRTSGSGGVGLGADRVDAVAAGTIASPYLP
SSPGRGRIDSVTDVFDRESTRLHARPTVAVEPSAKSVPSASPFMAAAPGASLASAVRFEH
HESFEPFVQLPNSRPEPSPSTALLSSTRWALPTRRDMTASGHDSSDANDLNDARARLLRS
AGSPLGRTTGVGLDEAERLAALRRYEILDTPPEPAFDRIVRLASHVLGAPISLVSLIDES
RQWFKARRGIDASQTPRSMAFCAHAILSDDVLVVPDARADRRFADNPLVTGDPNIRFYAG
APLRTPEGHRLGTLCVIDRRPRDLDDEKRGLLADLSSLVVDELELRRVNRVLGDMAMRDG
LTGLLNRRAFLMQADRLFGLARAQQRRLAVLMLDIDHFKGINDTWGHAIGDRVIVELTLV
LRAALRKSTVIGRLGGEEFAVLLPEADAQRALQAAERMLVAINGASVPANGTNGNAPVRF
SASIGVASLGPDDTDFSTLLQRADRALYAAKQGGRNRVAVL
>A0A380BZM2|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MAMTLLQQAAQYLKKALPLMLKHQIPTTPVNYALWYAYVSERNPALNASLDEAVNQYNTC
PPSTAELLYRHHLAPEDELDVRDMRQSIEAIATELSQSLKDTSCDADSFRAKIERNFGRI
SRLDQDAMDLEQVMGMVRALVKDSDDIRSSTDYLSSQLSKAQQEIDSLRLQLQNTEKDIL
FDALTGCLNRRAFDADFDSLLSQSPKGCCLILVDVDHFKRFNDEYGHLLGDQVLKAVAKR
LQDSCRDGTKLYRFGGEEFAILVPTSQLRVARQLAEAMRRALEKVSVRDRRKGQLISNIS
ASFGVAEWQQLDTRQSLTERADTLLYEAKRLGRNRVMPISG
>A0A0Q0HG97|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MSYESNRLTFFPPKNKEAFFFIFILLLALFITFDSHAADVCKIKHLNSSTPASVLKVNTP
SELTAQRGVNQYQINCSLENAGVLSFLRPGLDSFTWRQKNTIKAPLKSGQVAYLMDSGTF
TATITLESKLNYTPRFKWQHTHTYFEKTQQHSLIMGSFYGLCITLIFYVLIMGHRLNESV
FKLYSIYIFCIGSFILLQEGQLYLFVTQHVSGVIFNLYLLSIGLTVLSATWFMLALLETN
KRWPRLTKLLKALACAVMLSAVLKMLFTNLFFWTIAGYVMSYCSLFIVAVIFTLAAMQAL
KGVREATLVFVALSLVLVSMIFRVLLINQSPFMQRYGFVLAFAVESFLLAVAVSRRISRM
RIAQKRAETEADYDPLCSILNRRGWAKKSSSLIDLHTKKGGVLCLMYIDLDDFKQINDTY
GHAVGDDALCKVATCLKSSVRSNDAVGRLGGDEFVVLAHFYKNAQVSPKTHHLKTTLNRL
TINHNNDPIAIKASVGTTVFSEPPYSIDEILKAGDTAMYHEKLQRKVKPLTLVDG
>A0A380A9A5|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MLRYLRPILFGSLLLATAAVNAVTIPYCVDPDWMPYEGIDQGKHVGISSGFLEFIEEQTD
WQFQLVPTESWQQTLAYLKQQRCVFTPMLNYTPRRAEFLYFSDIYSRSPNVLVSRREQPF
LQSMEQVGDRSLVIPRGYRLLDYVRQNYPKIRIMLAETEQQGLEMVSSGEADLFIGSMYS
INARIQQSGLFNLKIAAWAGPEDQFRMAVTENGKWMLPELNRLLAQVSDEHRARLYRQWS
HMAVLEQTDYRMFWQLLTVATLIFGALLARNRWISKYNRELTAKNQQLEQLRNQLLETNR
ELEFISTHDPLTKLYNRHYFHRHFAAEHRSKTAQGHTSLIVIDIDFFKNINDRHGHSVGD
SILSELATLLKEGARENDLVARWGGEEFMIICPDTDCVQAGRLCERLASAMKQFPFSAGV
SLSCSFGLTELKAGESIWSAFDRADLALYRAKSEGRNRICCDPESK
>A0A4U1GPD4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A811G735|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MNWSVLNKCILMLILGSLVHVIWIVWKVFVLITPDLWQWINLPLLKFQLGLNILILITFI
ALIYPCSVLRKKVWVQNCLPFLAVGILVISLCRDGYVVGVLSPATMISYISLVTVGLVLF
NRKIVYCALIPATVFLIACGYLSLQGYIRYAPIFHLSSLPYQNKFWVLTMMYFILPIMIT
CLILFEILLSQWRHREKLIQQLSRIDPLTNALNRRSINDCLEKLERKPTKSYALVLIDLD
HFKRVNDQFGHDKGDETLIKVSEVLSQIIRDSDVVGRFGGEEFILILNQSSLEQAQIIAE
RCRQAIEQINLNSDSGEVISITASFGIALSNHMLKPQQLISQADKALYEAKACGRNQVKC
YQPEFLTEAKLC
>A0A811GEW1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MNLPAHQYFLLVVPSCLILIGSVFIAGHFLFKAPRFLLWMGIAYILPSIALGIQSLMTNQ
QLTMTAPWVGTLYLTGAWATAHGIALKAKSSSNLKISLLLILVGVFTLGYFAYVDENLWL
RILTINIITILLQVMIIPSVYAFFKRSNILNKMLCISYFVVVFYSVTRFLITLFYLKNVE
SISISSSNWWLMILALNILLCIWCAILIVATTIKELFTTLNNDRYKDVLTGLYNRRGFLE
KVNALALDENIEKFYLIMCDIDYFKKINDTWGHIVGDEILKAIADVLKESLRPHDILARF
GGEEFIILLSCPNDYVAMNLADRIRNNIQNKKYTKYDITVTASFGLAEVFREVDFMETLQ
LADQRLYSAKNNGRNRVCYR
>A0A485BD16|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTNWAYGITVALTLASGIAMLMASNADTAERQAVQQRQIFDQLTEEVETDTWELSDLART
YVINKNPDVLEEYRQQAQATIAIEHRLGKLKDSGATPQELALLREGLRIADELQDEQQAA
LASVARGEEREAIDLLYGKAYERELERIQTQIDHFRLLLDGRASGAIVQATEKSHTWRSL
SELMVGLTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPNFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFEDVIKVAELFAPNIAPE
IPGRLYILDLDPWQMRCVASWLSPPDEPELFHPDDCWAVRRGLSHPPVNGEPDIACYHLP
ESSAQWSLCVPLIAQGEAIGLLSFRNVTPATAPSRAYLELMAEALGLALANQRLRSALLE
KALFDSLTGLRNRHHLEDALHTQMNLAARNGTPLSCLMIDIDHFKAINDRYGHEAGDLVI
KNVATIVQRAVRDIGMAFRYGGEEFLVLLAGTNEESALACAEDIYNNVRNMTLRYGLSEM
GQIDVSIGIASFPQHTQSDSLLRAADAALYRAKELGRSRIVSFGMLKTD
>A0A7U7EQI1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas carbonaria|TrEMBL
MRIRRLFSLRPGRPSLRRVFYRANLTVALVSVCMAGLAVTVVGLLALRAYAEHNLHLITR
SMAYTTEAAVVFRDAAAAEEALQAIAAEEEVAEAAVYDANGRRLAGYQRPSGPMVGLERR
LTGWLLDDEYSRPILHNDRRIGEVRVSGSGGGLLTFLLTGLGGTFAGLLLAALGALHLSQ
RMVAKVLGPLDRLASVAHAIRRDRDFAQRVPPARIVELNELSEDFNALLDELDSWQTHLE
KENATLAHKASHDSLTRLPNRAFFEGRLSRALRDVAAHGQRVAVLFIDSDRFKSINDELG
HAAGDAVLVSIATRIRGQLRETDLVARLGGDEFAVLLSPVASPEDAVRIADDIIASMELP
IPLPDGGSVRTSLTIGIALCPEHGSTPEALLRSADLAMYHAKRRQRGTRLLAQQPVSPVP
IEKQEKSREPAESPARPGPADACPGRLPDATADRPDARTDSRPETGGVPADGRWVGVRPV
QQGAVRQQPGRHQPR
>A0A8F6D0G6|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESVSLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLCSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLPA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLVQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKNINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVRAIRENTEPRVTISCGV
SCWSKTGPMPLKLLVQQADEALYIAKRNGKNRLIIHQNSTTT
>A0A3P8KZ25|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSDFILARVSQTLANERSLELLVRQLLEMLELVTRMESTYLTRIDLSAQRQLVMYAHNSS
EMTIPEGFSVSWNESLCKRAIDDNCVFSNDVASRWRSCIAAQELGITTFFSIPVRLTDGS
LYGTLCATSRQKQPYNLEGEQVMALFANLISHYVEKETLVEQLRAANSALEMHSCTDELT
GLPNRRALFKHLSTIFPRARELQRNILLIFIDLDDFKAINDRFGHPCGDSFLLQVGERLN
ARVRQGDLVGRLGGDEFLIIGAGLEAEEQQAFIAALRKEIGGIYFLAEHRISYPGASFGA
IDVDPQKMDMESALRAADDAMYQDKKSRPQRDLPGY
>A0A7L6XIV0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C05|TrEMBL
MPHETTIENWGWLKMLARRFGPGHVVNLCFLIVMIFSTLLTWREVVVLEEAYISSQRNHL
ENVANGLDKQLQYNVDKLLFLRNGMQEALAMPLDFPALRDAVSRFEQQRDSRFWQLELDK
RRTLPLNGVSDSFVNQTHILSRDSDTLDNELTAALEVGYLLRLAQTRSSLTQQAMYVSRA
GFYVSTQPSALSSEITARYYDYVIQPWFKEQSQRQNRMRGVRWYTGQTTQLRDELQRVTV
SVPLDNGQYWYGVLAMTIPVSSVERFMEDAIDKDVEGEYQLYDSKLKMLAASTPALRNIN
TFDAREQATLAHEIEQDTEGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVQGDFGSISI
ALALLWALFTSMLIISWIVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARQLV
QRCRAQKQSLSVIQIDLDHFKSINDRFGHQAGDRVLAHAASLISGTLRANDVAGRVGGEE
FCVVLPDTTLAQAERIAERIRLRLNEKELLIAKSTTLRISASLGVSGTQETHEYDFEQLQ
SLADRRLYLAKQAGRNRVCASERG
>A0A7Z9CTE7|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MPDLQKHLPPKAPLAAGRANLLPALLVIIAVSALCIFISKPLGPWNVIFANSGLYIDLLA
LLFLVFMLWNSAKVRMSHVAVNWVRYGLLLWIAGGTFDLMDEIFVQPRWMGYYCEDLLRL
SGMLLTTIGIYKIIDRINILYVDARSQSLKDELTQLPNRRFFIDTIREKQGHQLALMILD
IDFFKKINDTYGHLMGDEVLFALGKQLAKLTSDKIQPARIGGEEFAIIVEGMSPEEVRSL
AQSILENVRTILINSDYPLSVSIGVGMRGRDEPQEAFIKKVDEALYKAKNSGRGRVEWAA
A
>A0A5U9GRU0|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3P8L3B2|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSSSLMDDMTSAEGQLYDTASD
SWYYYYSFTNPDWFVIYRVDNSTLIDLTRYETDIVAWGFALGAIVIILFGLYLRHASRTV
LMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDALTGCKNRRAFDSDIA
ALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRSVAREGLKILQPLQISLYRYGGEE
FAVVFTAEHLTHAHTLPRKLAD
>A0A3V9NSG5|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAELVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5C6CPX1|diguanylate cyclase|EC 2.7.7.65|Novipirellula galeiformis|TrEMBL
MALMMFLDLAIALSCAGVGLVCGWIMHAIGWGVDPADLNDDRSMIDRSELDHVKGEYERL
AAAADRLREYAITMAMDVDLHQSSVQAVSDALSSETSFSADELGEVVNRLIDANQTMQSK
LQTAQSRISEQADQLESAERRAQTDALTRVSNRGAFDEHLARRHALGPGRAGTLMLLDVD
HFKKFNDEHGHRAGDEVLKVVANMLHARLKSYGIVARFGGEEFAAIIDGYTVEESKQIVE
SARAAIGQHLVEFEGKQLAVTASIGLAEPLEAESIEQWIERADSAMYHSKNQGRNCGHWM
DVNTPELITLGDEPSSIPDIDEALPTVAIPPANQTAAPKPQPRVPAARPNHGAFSSLPDR
AALTGSFAELQERSKSIGLPTQVMQLHVSGAPAAGSMRTLLQIVRATMRSVDRIGAEDDS
TLLVCMPGINDDTAQEKVKQIRSSAESLQFGEPSTHESSKLDISVIAVEPDETLDEAIAR
TPAPVSPAPVSPAPVSPAPVSPAPVSPAPVSPAPANRDNATSPESDLKQTTESAVPESAV
PESAVPESAVPESAVPESAVPASNVPDQATSAAKTKSPAIAAAPNSAAPPPSGLPLKAEP
SSPPQVVASGS
>A0A399DYC4|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MFRAFLKRFGLWPTVALLTLASVVVSVLMTLALNGWRLDSSGVRIAILVPCIVAPLFSTL
QLRLIQQLERIREDLHRLSITDELTQTYNRRHFMHVAERRLAESGQGKGLSILIFDLDDF
KLINDRYGHLTGDAVLAEVCRRCVPQLRQEDVFARYGGEEFVLLLPATNRTQALEVAERL
RRVVAEHPIEAAGFSIPVTVSMGLASQHGSQQSLDELLNRADDALYQAKQQGKNQVLG
>A0A653YRQ7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MLLSAGRVERKLLALLAVAYLSLFVIVGAIWGSRAHLIDGQRVEVLHTSLYQLSETLSLL
KDAETGQRGFLLTGEESFLQPYNVAVQHLHSQFQALRAIPLMEMYADDIARIEQLAEFKM
TELSETIALRRLAGAEAARQRVMDNQGRRYMDELRERISSLEGNVSDELEALHESTDVRS
QVAIWGGSAVALLMLGLLGLTYLDLRRDLREREELLKRLAFESQHDALTQLPNRRVFNDS
LDQALALARRAERPLALIYLDLDGFKPVNDEHGHATGDRVLKAIAQRWRTLLREGEVLAR
LGGDEFAVVAEGDVAAIECLAARMITALDTPLLEEMPHVRVGVSIGMAQFPQHGEDRRRL
VAAADTAMYRAKEAGKHCFAWPESSSAIPAAAL
>A0A850F4R0|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium BIT-l23|TrEMBL
MSNILISSGRPTFRRILQRISILSVATAMIACWLFLSIASVLTLKQYAQQNMQLLGVTVS
HSLEAAVAFRDVGEIHETLTALGRQQQFSSALVRDSEGRPIARWPTTPRPRPKTPDALIQ
RWLLPDPVVQTVWYDGVPVGEVQLTAKGRLITHFIWLSLALLTGFLILASALSLAISHYF
HRGLVQALQNITEVVHDVRQNRHFSRRVKPEPIEEFQRFAHDFNCLLDEMEQWQKQQQRH
SASLRKSALHDPLTGLANRAAFREALEKVLTDPLQRTHHALLFMDSDNFKQINDNWGHAA
GDRALREIASRLLRFSARRYPTFRLGGDEFAMLISDVTIDEQIQRLISRLGYLFVPPMPL
RNGEAISLSLSVGYALVEPDSTSESLLEIADSSMYHNKKLRRGR
>A0A653ZRK0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MQRLTLSILLLLSLFSGPSVASTVQLSTSSSGSVLNGQIELLEDVDGQLSIADMADPAVQ
NRFQPAAGRTSVGQSSNPWWIKLSLQRSSDAPAQWWLEVGAVTLLDLQIFLPSATGQWQL
RQAGERVGFAEGRDHDYRRAVFRLPVLGEQPQTIYLRTYDPGGNSFPLRIWQLHDLEQLA
KREHLVLGLIYGVILALLLYNLFILLALRDPTYLWYVLTMAASLIFIASMSGHGFQYLWP
DDPVPAWLDRITLPILVSLGILRFAQALLSTRTTLRIAHHILNGCIAVYLLALAVNLAGY
RSETGLLIGLIPIVTVPTLLFSAAIRWKQGFTPALFYLLGYGSVLLSFVILVLRAAGVVQ
PGESTAYLFPLAVAAEAILFSFALAYRIQILKQEKADALQQADREKTARLTQAQANAAEL
QHSVDLRTAELAATNERLRQREQALQHAAFHDPLTELPNRRYLVERCETALANARRHSEA
LALLLIDLDHFKPINDKHGHDAGDLMLQQIAQRLREHVRAGDTVARLGGDEFAVLVGGAD
AEEHAREIANRLLAELAKPVMYGAERLTVTISIGVALYPQHAGTFTALYKAADEMLYRVK
TRGRSGSAVCGEDGELSNSARLHLDVLSVPSGLL
>A0A517PZ89|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGAYMHWPLGVAPLLLLAPPTVLAAVSSPRVCYW
TITVLSISSCFAEIFFRPDLEEVRSTYPASIMCASVLVGLVLLIDLYMGKLRHKLSQMHD
QNDELVRQLYQTQKQAAADASKSGITQINEKPVSEQKENTSVESGVNYPLLLLTLQDIGR
RISTNQSNESLIPTVISTAKASLQCESCQVYLWDSKSRALKNALPARARDRLDYRPAANH
GVAAWVIEHRQIVMRNDADQDYRLKRIIEDDPQMPDAIAPLTVGSELIGLLIIDKIDVDS
PTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLYNHATFQEKLHELVKGAEAQS
TSLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPDNAVLARYGGEEFIGVLLD
HEYSQARQIAEDLRETLENCPILFEGQQLQVTASFGVTEFRHPATNTKDLVRVADEYLYK
AKEGGRNQVVGLDTNATRKPGT
>A0A4P5Q7J8|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. A111|TrEMBL
MFGEAIQRDFSRFKNPRNIVNLCFIVVFIFSTVLTWREAVVLEGAYVANQRNSLDNVATL
LDRQLQHNIDNLLFYRNTMFYALQSPISTDRTRKSLAEFDLLRTEAFWQLRLDLNRSLPV
NGVSDEFVNSNPLLDRNDQTVHTELSSALELSYIMRLSDRSRTLPQRIFYASRSGFFLTN
TPSANDPKIISLYQRLISQPYFSSQSPQNNPSRALRWTHTFDANSTTGQIITAAIPLDFN
GRWYGILAFDYPIDSLHDFLQQAKYDDHEGTVLLYDNELNPIATSAKQLPKHELFTAPQL
AQIASVVTAAKPGEQGELRMDSRFITWAKLNNFDGLLVKVHTLEEGVQGEFGRISIVLSI
LWMLFTLMLVVSWIVIRRLVNNMFSLQKTLTWRANYDTLTRLYNRGAFFEIAQKLSQECK
QQAQPFSVIQMDLDLFKSINDRFGHNSGDKVLAHAAAMLSDAFRQGDVAGRVGGEEFCIV
LPDTTLEEAVKVAERIRVRINTKDLLLKQGNITRISASFGVSSAQEFNDYDFERLQSHAD
HRLYKAKQDGRNRVCSHD
>A0A7W6PAF0|diguanylate cyclase|EC 2.7.7.65|Martelella radicis|TrEMBL
MMENVGILATMLEKVGLAALVILTYRAILRSRWPALWSGPAIGLLFSFGAAISMIDPLVV
GPGFILDIRVIMIGLAALFGGVWAALIAGAVAVTIRILIGGAGVMPGTVSIVLATIVALA
FVRYCGNGRDLRNLALLGLSISLSLLTVFLLPLDFALSTAFHSLPALVLRNLLGTMILGY
FLAMEERREVEHKTFKEQAERDALTGLSNRRALELLERRDSGHQTPELFCVIMFDLDHFK
SVNDSYGHGLGDVVLARFAEIITRRIRGSDIVVRYGGEEFCVILNDALLSNAARIAEDIR
GQLADEIFSHDVRVTVSAGVAQSSAAVPSVYSVIKQADQALYEAKGNGRNRVEIHTS
>A0A0H2M6U2|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MNSSGLGNIRISLNSRLSLGVAAVVLAATFAIATVALHLVKTSMKASIESEAFARLSAIA
NTVGQKFVSRRTLLETFADSVASNEFPDAPALQAFLERHPSLRKAFSNVAFFTADGDLIA
SLSGAQQLGRVNIKDRPYFLQTIASQAGVVSEPYLNRLSGLAQIAMTEPVLDPAGNVRYV
ISGALNLKDRNILGELTDMKFGETGYLFITSTEGVVIDHPRTERIINQTGLKGVGNPEIE
RPIEGYEGATEGFNHAGVHGLYAFKRIQQTNWVLGSMYPSAEAFARVDAIERSAWIGTVV
LAMFAGAMALGLVRGQLRPLTHLHRHMLDVDNPALETAVPRTYPRDEIGDIARTFDTLMR
QRKSSEKFLRDITDNLPAMVSHVDAQGRYTFVNAPLCRKLDRGAAQLIGRAAQNVGEDET
GDAAVRRVLAGEAVSFESRGQARHGEEDRYFQTELIPDRDQAGRVRGYYAMTSDVTERKR
IEFSLAHSEAQVRVIADNIPALVSHVDSSLRYTFVNAQVKALHKERAMVGRSMPEVRGPA
DFAIVAPAYERALAGETVVVEKSGDAALGIGNRTFKAHYIPDRDADGVVQGVFAMTFDIT
DEVNIRKALTEQEKRLRDVTDSIPALVGYFDSSEKCLFANSRARQMAGLGDGPLDGVTLR
SALGKAVHRQIRPYLPLVREGKSVRFPVQAPLHGRDGYFQVNLVADMDPQGDKLLGFYLM
TFNITALKRAELRQAESERRLRTITDNLPALITYIDRDEKITFANATYREWLGVEPAGIL
GHHVSDVAGPELYLSRKAMIARALAGERVEFEAQTRTQGVDRATRVSYVPDIGPDGATRG
IFSLSLDISALKAVERQLSDLARFDTLTGLSNRLAFNEFLPGAIARAQRSGNALAVLFLD
VDHFKTINDTLGHATGDGVLVEYARRLLASVRTTDTVARLAGDEFVVVLENVHTREAAVA
VARKIVQQVGTAPFEVDGRSLNVTTSIGIAFHQAADASVTAADLLARADAALYRAKAAGR
NTFGFSD
>A0A1B1NN45|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTLTLEKKWLYPLITFTVTALIALCVGYFSYLSQQRYSQTIFENLAERQTEVLAEFIGSD
LDHIGAGANFFHATDRDEWDHFPIFAQQVVGASQTLVTLQWMERVEEAQVDQFVANARLQ
YPNYQIYTIPKGGEKTLGYIMPAEEPIFAARDIYPRNASNESVLGFYSSRPRFQLVVDNM
RIHHKPSLSDKVRLIQDGLDSSLERDGILVYHPVFDMETNQRLIGVVIGVIRTSHYFDGL
MVRTAAEQKLEVKVVDLGFDAEDDPVLFESDNWATTDGLEVRKVLDLPNRQWAIYFRLGD
KVTANDLLIVHGILFGGFVIACLLSYIAYLQVRAKSNLEHQLAQRTKELQFLVEHDSLTG
LYSRHAFNQFIAAMVEEDRRFTLIGFDVDKFKLVNDNFGHAGGDKMLIHVARTVEQCLEP
GDIFIRLGGDEFGIISNVIERDKLNTYLNHICSTVFASNIQIAEQAVCCSLSIGAAIREH
DSVEQLIHSADAQMYKSKNAGRNTVSIAE
>A0A1B1NN18|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MVRLGLLRGFILAIVSVFVTCCLSMSAYASEQYRVAIEADDVVTRVLFDAVSQRFEVDIA
YVYYPSFNDILTAVESGESDFAANVTYTPQRAERFDYSSPTNIEYTYLYSYTNTTLETIK
RVGIPKGTIYGELIKKYFPSLTQIEYSGHQQARHLLDSGQVDGVVDAINQLKPMLLAGLD
AQLLNHQISIKPVSLIGTKDRFQSQLKAFEQHLHSAPVQKLLRETVNQYQFDIRQKSLRD
LVVASGIDRSRPLKVKIEHAGQYATYHDNGQVTGITPDVLFSACDILMLNCKLVSRGDET
WEDMYADFLAQKVDLISPFAKSEPRKQFAYFSVPYYQSTAIMIKREGYKNNVYSNVSELI
VERIGVVKDDFYQELLESLLPQKTLITYRNAEQQIAALLAKEIDYVIITRSSYNKILRES
KTLLPLTEDKLIGEFYTSNVTIGFTKNARGKSLVPLFDRAIKMLDLEKITNTHYVQPDWK
AALQSEQRLARRSIAVVALGLIASILVSLYLHHQSNTDNLTRLKNRRALQRRYSKDISPH
LTLVYLDVNNFKPINDTFGHEIGDQVLKHIAKQISRYWKGQSYRIGGDEFILIGSVDSVT
LSYALLNLQKLQFTSQDHRITLDVSVAFGVSKPRREAMTLEDVMHQADLSMYSHKRKVTE
REINVAKQQIEQELNMIQP
>A0A0H5LW26|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MLTAHLDALNILSTPIWVVTPKNQELLFANKEARKIAGDCQLPLMRNGRFSAHAQQQLDA
YLPALVGDDQIVEIWTIEREGNAFPLSCRLSLTQLEPYGDVIVFEGLYISDKVLTQPHVG
QLCSTSYRRDEMGFYEQFFNTNTAPMLLIDPSKEGQIVDANQAAIRFYGYSRDEMCMKHT
WEINTMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNIRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEQAHAQSQRYGHHFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIIRESDSVFRWGGEEFAILLPLTNLEGALQVAESIR
ETIQMICQPNLPQLTVSLGVAQHQIGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A5I5DX00|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Miami|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSTEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1E3WP60|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MNNIAQRIVERVDIKILIRIGYIIAISLISYTLIMEHGTVGWSYVLFPIGMISALVTKSL
RRRKLLAFLSFIHILVGGLIEPLELDAIEEAFLLLPLCYLVLFPATIWPVLIVVSLVTHY
FFTTPAELLPELIEDAIELLLITVFATIMTYYKRKFDEQLKVYRKESLSDFLTQLPNRRA
FYEYVNAYADTSIHNRDFVLLKIDVDNFKDVNDSFGQHQADNLLKSIAEKLKYIVIDRAQ
LFRLEGDEFVILLCERADIEHQVSGMVRELMRSEQFQFEFDRGSYQVTFSVGVSSLKKAA
NNHDIWLKNVDVATLKAKTTGKNRVRWYDESLLDETIRSHQIEAELEQAIKLAQFALVYQ
PKVCVETQCVTGAEALIRWEHPNLGTISPFEFISIAEQTKQIIAIGRWVIRTACQQAKQW
ADAGTPITVSVNVSTVQFAHDDLFPYIRHILRQTGLAPNLLQIEITETTLMKDTERVTKI
CRRLQNEGVTIAIDDFGVAYSSLNYLKHLPIDVLKIDKSFVDDCVNEHNDHMLVRTIIQL
GHNMGKKVIAEGVEYEEQRVLLHKEECDDFQGYLFSKPISANEFTHRFVEQRCPA
>A0A5E4WFN8|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MPDAMPAVPSTSSAAPAAALPSAASDDAVMFDLAPVSLWLEDFSGVRHLFDEWRAQGVTD
LRAHFKTDPAHVSACSQRIRVVKVNRKTLSMFNAPSLEALVANLPRVFRDDMLKTHIEEL
CQLWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHETTLDRVLISLEDVTELEHARERV
TMGEQYARGLFEYSPVSLWVEDFSAIKLLLDDARARGITDFRTFTDVHPEFVERCMNEIH
VLDVNRHTLAMFVATDKATLLSRLPDVFRDDMRHNFREQLIDLWENKLFQQREVVNYALD
GNEINVHLQFAVLPGHEPRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYVD
ELNRLERKGPFPVTVIVADLNGLKAVNDQLGHAAGDALLRRAGEVLGKSVVAPQIAARIG
GDEFALLLPSTDATGGAAMMESIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEATVQK
ADLLMYEEKRNHYAGSLNERRVLDGLPSGSGPSGGGVGGA
>A0A0S3PX44|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MMQSIGRRLGGSDKDLPPWVQRQLLTYSFAKKRTLMFSIIASSTIAFAAIVMTQALWAYA
WLALELFFGCFRWINVARYDAHEKRGQRGDAETPLVFSLIWIACLSCALVVGVTTGDVPL
ILLLGTAASALVGALSSRNAGTPRYTIAAIIITTVPYSLALAISPLPYALILPLPLMLTT
VGMISVMRDNYNGLVTLFTAQYENARLAQSDPLTGLSNRAQEREQLNAILKEAENAVGVA
AEVQVLYLDLDGFKQVNDHHGHAAGDSALQLVAKRLRENVRAVDVVARIGGDEFVIILPQ
TSVDVATQISRRIIARISEPYEIGIGKPVRLGVSIGGASYPIDGRSPDDLLASADTALYA
AKRQGAGRHVWANIHPVASPTLAPGGNGVLGAGERSVADPIH
>A0A508TK50|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium ivorense|TrEMBL
MVKLLDEHERTLAFADVALGQIRSLRQTAVPRNYEIWYVYATGYNAPLNKVINETLARSG
KLSESDLEQIYETYLSHIKTSDRIDKVGARVIGEIDDVMKLITDALGVSATYDASLIGAR
DKLATATSRDQIKAIVEGLVKSTREMRDTNMALENRLALSKSEISDLQHSLEAIRAESLT
DPLTGLGNRKYFDRSIDMAVQTALASSEPLSLLMFDIDHFKSFNDSYGHLTGDQVLRLVA
QSLKQTIKGQDITARYGGEEFAVVLPNTALRQALTVADHIRRAVMAKELKKKSTGEILGR
VTISVGVSMLKPTDDTDSLIERADACLYAAKRAGRNRVICEADPEYSSETQTRVA
>A0A0A0FE83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli G3/10|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSVAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5A9FEZ9|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. B21|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYREGRGGERSSAPASFQAWCQAASHDDL
LQQPAVQKLANLHEQMHRQARLILLKASGGEPPTEAEYEGVIGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETGLDEGYAVIERLRVDLMRSPVMLPDG
RLIPVTASFGLVEAVSDLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEPKPVPVKAG
RG
>A0A3P6JG39|diguanylate cyclase|EC 2.7.7.65|Clostridium carnis|TrEMBL
MQDYKKLYDSLKCEYEAYQRFSEKHIQELCEVNVKLENSNNSLFNIVEISKYINTFFSDD
NLISMINDMIIGILGVANSTIFLMENDELIIKATNIEDSKINLTSEEIKYVYSEQEFLIN
SKDPIKQVGSNCSDIHSVMGVPIFLRDKFMGYIIVEHKVYNFMTVELKLFLKSIANQIAI
SIENSFLYKQLERLSQTDPLMNIYNRKYFFDYMEKVIQQENYDKCAIVMIDIDNFKVIND
NFGHQFGDKVLINTGKIIKSWLGDNDLMARYGGEEIILYITDFDDELSVYNKMNIVRRAI
EGSVVSFQGKEKSVTASFGIAYFPMNSRDINELIKIADDLLYKSKNLGKNRVISAHDEKF
KTLLC
>A0A173VDL4|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MTNFGEHYNEELAQQEIEINKKTLWEMVGAFIVLTAVWGLAFGRFPTANAIVFSVTYAIS
TGFFIASVILFFKADPSDERMKNFFVTGICIISAAMNLMFSYHMVLAYVFPLIVAVQYKE
KSVLWLSYALEVFLLPVSMIMGFYYGICDLNLLLQGNHTRTWYMAELADGFAKLPFSKMP
VVVIIVYGILPQLLILFVFVMIIQHTIGSMREDAYRIAELTYRKEVDSATRLYNKNKYED
MLANYYTMVERVAVVLWDINNLKEINDRMGHGMGDKLIETMSGAIYAQTDSRKKAYRIGG
DEFVMLIENPEKQEAEQIIQNVRDKLARHREEGGLRVSSATGTAEGNGIDILKIVHDADE
RMYEDKKRGKESREYAMFYSE
>A0A3P6K672|diguanylate cyclase|EC 2.7.7.65|Clostridium carnis|TrEMBL
MEILIKNKSEIDDNEKLKIANRIVKCISEYSAKNQIVILIDNLEEKHEIIKLLLKYILLL
DRNTENIMVVFTVNNSYCDEEVSLLLKQLEKLEKYEEYTINYFNQYNTTKMIKNILNYSK
EIDKLSMEIFAKTLGNPQYIISLIEELYNNNYICFDFKSGVWKIDKEFKSIAIPEKIDSK
VNFMIASLRESEIHILKKLSIFLTPLPERIILKHVITGEEGIEAYNKLKEKNFLADKIGD
KGLLVGFTNELLKNILYSKIDKKTKYVMHKNATEFLEEEIYNDDSYVEEFLYNLEKIEEF
NKLYFYTIRCAQVEKIYGNPSKSIQYYKKTLKYSDDKNKCNIAINIAKLYECISDHENGL
KYFKLANEYSFKRSKKDMQIYTNIEIIIIKMNNFNECNQDIILLLQNIRKQLDEINYPKG
EVYYYYALMLKARIEEEYEMILEYGSKVLEILDEFRIKDDVHGWILNTIALEYRRIGIYK
QAKKLIFNSTRLFENNKNMNGYIFSKNIYTELLKEEGRPIEKIIDNLIEISRLSNRNKLY
KREIFSLINIAICYLNIDNYVEAERYITKTLERQRDESVEFYSDIIYSTFCLLQIKLGNI
RLAVKYHTLYQMFLNNTKNPEENMIDNSISSYYYNLIFYNYDEAHEILRKIYNKISNKND
YKSRYIVCNYYQMLLLKCENELDVKNIYNILKNKLEYINNINKQIEIKLKAIRFILKLDY
RTLANKLFNEIKDYPNNYNMEAYYIYLELYFKDNNSHYNYLINKGLRVCSLSVEKEIKRD
LYAIIGEKYSEMECYKLAFYYYYESISLHVETLKELPVKEQLIYINKSNFFYVYRLLVEC
LNDKLKIRINFKDFHNINNENELNDILNEIKITRLLNNQSIYNLTQGLYERLYYNNLNNA
YDLFFTFNEDIIKNLGSIVKYISKITLSNKALLLIENENGENEVVYSYRINNVNTVKSYF
NNKIESQDNVLILSENDIYFNNLEIESMKIKGCMYIRIRNEETYLNGSNKINGKLILLSD
NAINNINDSSKILVEKLVPFIKFMLEKYNLTISSTLDKLTGAYNRRYFEQALTRLLDNEK
ATNNIFGIIMFDIDDFKGVNDKYGHQTGDEVLVKVVKEVKKSIYKNNIIGRYGGEEFLIL
IPNADEEKMINLAETIRENIEKAKILGEKRPITVSIGSAIGGNEVLSSRDIISRVDRALY
KSKNAGKNKVTFWRKEFDENIEDVDINGGMISEMLRSHNLDLVISDIVNLMKYNITKKER
IHQFSLKIINTIKCATIGVFLIEDYKINSTFVTRLNGEFSSDLENFNLNFVDKVIGDGKS
IYNIDWNNGKKYEGNSIPEWKSVCLTPVISNGKIIVVLYLYDSINNKEFDNNDCILLNSI
AQLSIPVFL
>A0A1Y6IMI0|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MKKQYGVKGILLAPLIFAVALVALLFEGHISQLDRELDDEYERIGREFFRASKMLTILDY
SFNNYIKVRQSLRLTHTRQIVNGVCQMRPKLNTTAADGDDVNSQPVNPKYIIVGDEALCD
RSSALYHDVGFRIALAPVISFLHDLDDYLIGVHYIDPSGYVISSPETLTVKMTPEVLQLI
KSPDWEVYQNLSEERPIKVRGPIVFREIQYSEPLLSLMLPVYANHQFEGMISLDILLKKL
LGSNRRFAGKLNMIDTRVAQLPPDAYRAFHLSEPGILFHHSIYYRMSWKNELYQFVHMKK
NMLFIVAAMYVLAVMLFLFMNTRSAKSYYEGLAVRDPLTGLRNRRGFEAFLESKQHQSYV
AIAMFDIDDFKAINDSFGHDVGDDVIRYVGDQVRCHIRSTDTVARYGGEEFVLYLTAEHE
SHLKATLLRVKEELCNESDMVVEKGFTISGGVEIIASSELNDIDAILKSADKKLYAAKAS
GKNQLIF
>A0A379T203|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MFLPVAAVLVSQHVSGGWWLLLVGWSFVWPHLAWQWAMKAPDPLQQEIYNLKADAILTGM
WIALIGVNMLPAAALFRMMSMNLIGAGGLRLFFAGRGLFLASCLATLQLTGLPIAMRSSS
LEVTLSLPVIVLYPLLFA
>A0A6Y2KDF3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A2X4U2D8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MLVGWSFVWPQLAWQWATKAPDPLQQEIYNLKADVILTGMWIALIGVNMLPAAALFRMMS
MNLIGAGGLRLFFAGREAFSGVMSGDVTAYRATHRYAKLVAGSHALFACYCAVSAPVCLS
KLSDSH
>A0A7H4PLS1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MRVNIKSLPCRIFIYAIACSLSIAVVNFITTSLIHRISTTSSMLFPVLTISLMGFHIMIA
CFMGMKYLCDKKQLYLAPIAFAFTCSALLMLGTIGSYPDWLVCAQGREINQNDALIFYFF
RNVMMAVLFITSIILYRIRHITGHSRKIHGAVLSSCFIFITATLILSWVHSSNSPLLSIE
FIDNLTYTFTPLWHNRIGWLLIIIWSLTLILLIGLTRLRNIFWYSGAFFCTAYIFTLLVL
LSTVSGNAHSWNQARLFETLSTLFLILILLGDVFILYRESNERYVRSYQNSIRDPLTRLY
NRSYFYDTLTQRLSKASASQPLSVIVCDLDRFKRINDTYGHVQGDKVIQFAASVLQNNVR
QDDAAARIGGEEFAVLLVNIAANEALAIAERIRLSVSEKQEGLPERMTISMGVFTTQDAH
VSAEECVKRADTAMYEAKNSGRNRVVVWRE
>A0A1V6AL58|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MDYLRKKYRILQITIILIVGMVISTIIYVGLKDVDDMYHNYAAKSIMDIKKAYLKDTVNN
IIAGIKQKNDDQVNFYYHIAEDITNILDNYYHLDSEGFYNYTKQYMTQEIKKANFTFFIV
DRQSQQILYMNIPNKEESEIIDIGYINSLSDQLPVYIKKAYGKYSIIIGIDQKTIDNQVK
DLLYNEIHSYKFADEAYVWVNEVVDYEGGDNYAIRRIHPNLKESEGIYLSTEMTDIKGTF
PYKTELDGVKQYGELFFQYYFKKLDSDIISEKITFAKLYKDYDWIIAMGVHLDDIQEYVN
YTSKDKNEQVSMLLIIISLTTIVLICIALGVIHFLEKWYYNNSNKTLIEETQKDPLTQTY
NRRAAYKYLSTSWSNYKSLGINSTIMMMDIDNFKKINDNCGHSVGDKVLVGLADKLNSHI
RSNDFLCRWGGEEFLLICNGLKKQDIAAFSSKLLKVVEEMNFECKEIKKFNITISIGISE
FYPEDEQFSIAINRADIALYQAKAKGKNRCIILEENTEKCNS
>A0A447RA04|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCAPMIGILVLSVLLLVW
HGKYGQKRVNLPFISILFGGLWAAHIALKYPALGHYDFSFLLTSLLSVLFIGSIAFAANI
VAFTLHSLPSVAVCLWLNGHEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFTLLT
ERETLNGLSLLDPLTGLYNRRGLQSRLDTLQVQDSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTAAEPQQARATAERIRQKVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDTI
>A0A7H4M0X0|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVRDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKTSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A7L6DN84|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00903|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A1Z5I8B0|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MTTLAWVIPSKVVASTTFQPNTITSQQSLRVTSKEISDKLLLADRNRRDDPLVYKKLLLE
LSQIKDSFNVEQGYYYQFLQGYLATYRGEYDLADNLLTELLTSSANNLLRFRANYTLINV
AAAKKDWSDGLRHIALNKEMLSLIKDEEHYQVSILTTMMFYNQIQQYNLVLNDVALIKRE
NLSLQHNCFVEQLSLEARMNLQQAKPDDESIDAALSICINAENKVYTNIIRVYRAKLYLK
ALKADKALMTLLPHYDEINATLYPMLTVSMHNILANSYFKLDNLLDAKKYALEAVKANKY
INAFQNTDSYRLLYLIAKQEKNIDLALSYHEKFSEAETERLEGEKSKYLAFKLAELQAFE
HEKQIKLLNKENDFLAAEKVLSNTKVANIQLIITVMTLIIIMLTLGGARLWQSHKRVKVL
SEYDELTGIYNRRHFTQLAVSTLKYCKTAQQDLSLIMFDLDHFKKINDTFGHICGDWALK
ETIRVCKTIGRTNDVFARLGGEEFCILLPSCNIEAAVRLAEACRAAIENTITEESGNNFS
ITASFGVTDVKRSGFNLEKLLADADFATYDSKHSGRNRVTIYEPETPEISESLEGSWRVA
S
>A0A8F8XUI7|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MLKELFLNLTILITFNYLFTVLFKESLSYKEDRLMFQLLKGTVCGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFIIIVAGRILINFNASAIYSIAAVGMIAILSVAVF
RGKKPNHKNAFVMLLFSNVIITLTLLLLMPEQPAGALVYFWLISTLGGMLSLYIIKHEAD
ARLLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRASQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSDPSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTSDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A6D2G8J5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYNHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
ELEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A1V5DU49|diguanylate cyclase|EC 2.7.7.65|Smithella sp. PtaU1.Bin162|TrEMBL
MTNPRKKNHTRAYLERRIRHLEDVERSIVDGLEMAASLGDFQNSISKLSDVSTLLEETKK
RVQGLIPFEAIAFFMVEEASNDFIMKYVDAEIYRSYLQSEVEHFIDEGTFAWALREKRPI
IVPTRDNKGMLLHVMATTTRIRGMCVALLPQYNQHLLNTSLSLLSTVLLNSANAIESFEL
YRTIREINSNLERIDNYRLLFAAAPDGVEVLDAAGNILDSNDSQTKLLGYMQAQLLGSHS
SSYFAEGSRASFTKNHLSLKKKGYWEGEVELVTAKGDVISVWRKEKAIYDKDRKFIGAVV
YNRDITERKRMEAEIISFAITDPLTGLHNRRGFLSLAEQQLKLAERKKQGLLLYFFDLDE
LKSINDTLGHQEGDKAIIETAAVLKDTFRASDIVARLGGDEYAALAVDVAEANAKIFTDR
LQVLIDKRNRRKNRRYKLSISAGCSYYNPENACSLDELMSSADRLMYEQKQNKKGPAIS
>A0A127MUP2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MQSVSTGYAMESMGERHHAGLLRLALGHLALDAAVLMRDDGGAWRLCACLGLGAEDRAWL
ERPGGLPDDGAAALAARWAFRHLCPLRSADGLPLGQLWLLGERPRELDAPQAEALAEYAG
LAAALLELECGAERTRITERRLALAVEGSGTGIWDRHVPSGVIHYSSGWKALLGYAEDEI
GERIEESYARVHPDDLAYVRATMEAHFAGQTAAYEVEHRIRRKDGSYMWVCSRGKVVERD
EQGRALRMLGTTTDITAQRVLAEKLRQNLELLTDLTNEIPGMVFQYRRLPDGSARFPYVS
AGSREIYGMAPEELADGPTERIRAIIHDEDMPRYLAALEASARTLVPWQLEYRVQLPDQG
LRWRQGNAHPRRQADGSVLWHGFITDITERKRIEAELQVLATTDFLTQLPNRRCFMHQLQ
AELGRVQRGGERSAAVLMCDLDHFKAINDRWGHAVGDLALRHFADVLAGLVRRSDCVGRM
GGEEFAVLLSDASRDNAVAFAQRLQEHLAQTPLLHAGERIPLTLSIGVADMLAGDATAEA
VLSRSDLALYRAKQAGRNRIEYL
>R8WYY6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. KTE151|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A5P2ME89|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKAEYSPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>Q18BU3|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNREFMYQYIDDCISKNIHI
GIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKGIVAYLKGEGFLIVLPNVS
NKELNNMGATIIESARELKIKLPNEKEIYSNVTFSIGSTIWNGEPNMTTLMLFNQVYSAL
KKAKSEGKNRYILFDFKDNSFYNKLENDKEFLSEISHVLQTKQIEVFYQPLYNIKNNTIV
GCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDLHLFEENCKNIRRWIDNNDVFVPIC
CNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIEITENILIENTNTIIQQLAELRSYGFS
VSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLSHNLNDFKNTTILYSIINIARALGMLTVC
EGVETEQHVEFIKSINCDIAQGYYYAKPMECKEFEKLLSKENNSEKMFIKYSDIGKSLIE
KIFDGFFIMQDMKKLRANVTEDIQWFDFYNKTEITSFPKVIEHFEKHIKGKKFSILYKSI
TPHNTESDSLLISGEAVLSDEASEHQKYSNFYFSANCIISENKLLLAKLHLDLIKTAGYI
NEFESYSIPKMTNTHLDESNILSQFYSMLPVGIIRYDLFGDMIITYMNEEMFDIIGYTKE
QFFGEMGGNLRAIVHPDDLDFVYKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLS
AIDGRSIAQGMYVDVNKIKNLTKI
>Q183X4|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MKINKKFNRVDMQVSILTAIIVIISSSCVYFFNYTLTYKSMIYSLSERSKHIYEYVERNI
DKNTFTEINSKEDQSKKSYKSSKILLESVKNTTGVMYLYTAKKTKDGSLVYVVDGLNSSR
SDFRNAGDLIEKEIWGDLNKALDNHILLPKKIKSTSWGYIFISYFPIHNDVGKVVGVIGI
EFEAKHQYNTFKFISIVTPIIALLTCLISALIAVILFKRISNPTYTDFANTDYLTGLKNR
NAFEIDMNNLNNSNLKNLISIISIDLDGLKKINDKFGHQTGDLYIKQASKIIQYVINKKY
IVYRIGGDEYIIILKNLSHKEINNIINNINLKIVEENSTNELKLSMSIGYAIFDEKVDVS
LFDTYRRADSQMYDNKRKINKQYQ
>Q18BU0|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MSILLKKAPKLAKHIITSFYINRDINEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAG
QDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENAQMILEVNQRCTFEIIEDRGKLL
IKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDS
TYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPDLPKALEDCERCFAKGPTYSSEY
RIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNIT
DIMFEYDIENDTLIKYQRVEIDKKIELENFETKNYSKLLESGKIIHLDDIGKLLEVLHGN
LRETIEIRQVNSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQ
RDPLTQLYNQRVSQNLIEEYLCSSDSKNNDALLVIDIDDFKTVNDTFGHLEGNEVLVAVS
KILLHNTHDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIG
IAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSTYE
>A0A1T5I1J5|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MLTFKRFSSNYSIYIKIALQLLLFLASIYIIFQALIKIGFFDKDTLNVIHNHHVKLNILL
ICTLFFVFFYILNRINKWFIKPLHQLKNTTNNQYSIYNNENIHESDIFKCYQVMIRNATE
KDTNIDLEISTLTKEKQTDIHQQQLTSSIFNNSQDVIIFLDSNGIITRVNPIFCRLIGLN
YENIIHQPLINFIHTPAYEKIKASLSHGLNNSHQWQGEFNIQHMVSKKNIPLYVKVNKLI
DIKNNHIQYSIIATDLTTIKEIDRLVYINHHDPLTELPNRIALTNRLNDELKNQLTTHHI
FAVLFIDLDSFKIINDNYGHQIGDKVLKITANKLRNAVKKSDMVARLSGDEFIAIINPAT
KHTDVIKTCKRILKILQQPIIINQHHLAINASIGCYYVHPNMQQTIDDILFQADIAMYQA
KMAGKGCLVECNSF
>G2DD42|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MKLLIAEDDLTSRTMLAAVTRKWGYEPIAVEDGEAAWQVMQEDEAPRLLLLDWEMPKLDG
LALCQRIRQQQSSNPPFIILLTARCETGDIVAGLDAGANDYIAKPFENAELQARLQVGRR
MLTLQQELLGAKDALAFQATHDALTGLLNRGAVMQVLEKEMARAIRLSQPLCIGLCDIDY
FKRINDAHGHPAGDAVLQEVTKRIVGALRPYDQVGRYGGEEFLILLNAKQDQAQNLLERI
RRAMADTPIVIEQAKLEVTISCGATLFVPPEDKRGGDALLTIADAALYESKAAGRNCTVF
SPPPFAAHP
>A0A8G1D8I7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MSQATKPLPAGFTEQQLHTLFDLISDGIWDWDANNGYVYRNPGWYAMLGYASHSLDNSVL
TWESVIHPEDYPRVMAHFEAYINQRNERYLIEYRCRCQDGSYLWIEDSGHVIARNADGSV
ARMLGAHRNIDAGKRLVAELEQRNLSLEGLVAERTRELSWVNQQLQRQLDENRELAERDA
LTRTANRYRLEKTLEQACERARRFREPLALIAMDLDDFKPINDLHGHARGDAALVEVTER
IRQCLGEQDLLARWGGDEFVVVLPRTSQEQAREAAQRIQEALAEVAPIGQCQLTMSYGVV
QWREGEERHDLLARADKALYRAKAAGKNAVAE
>A0A7S8FFI2|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira kreftii|TrEMBL
MASEELSPVEPQRSPDHDTLPSTREQVEALHQLLAELAGCADENDITKTLAKGLPRAIPT
DVIGIASSSHEHVRIWSNDRSREQEARLRRYLLRRLGHLPADSVRRPIPLQLVPPRHLSH
ALKSTVQPGELDGSSRNSHEMPLMISEEKKGLLVVQRIGTQPYTAWERQLVETVGTVLTL
CLRNLDACQRAQDSTLRDPLTEIFHKQALDSALTRELRVGLRYQVPACLLLLGLDFFEVV
NERLGQSAGDHVLKAAADLIETTIRDLDIVGRCDGDKFAVVLPHTDRRRARVLAERLREC
IERHLFVNNTGQVRTTVSIGLAAIPDIAVASTVDWMTIASSALKEAKAQGRNCIAVHTPR
PPALACAMTLSLAA
>A0A5E7ZIV5|diguanylate cyclase|EC 2.7.7.65|Hoeflea sp. EC-HK425|TrEMBL
MPFYPLPAQETERLEKLRSYEILDSLPEEAHVRITRLAAKTFNVPIAAISLIEGDKLWFK
AHIGNAYNEISRKLTFCAHAICQDEVFVVEDATKDPRFSDNPYVTGAPHLRFYAGAPLRA
SGGLNLGTVNILDTKPRTITDDERESLADLAAMVIDSFEMRQLLNRANAAERRFIDAMES
LPNGFVLYDKDDRLVICNERYREIYAESAKYIVPGASFEEIIRNGVENGQYPDAIGNEEA
WIAERLEMHQNPGEPIEQHLPGDTWLRVQERRTSEGGLVGFRFDITELKRQERELIRLAW
TDSLTDAMNRHRFMDLAGKEIERTKRRNGELSLLLLDADHFKQINDKYGHAAGDAILKGL
VERWTRSLRSHDLIGRIGGEEFSILLPEANAANAIRTANRLRKEIAEVPFAFEGQLLRVT
VSIGVATLAAGEDLPSLMQRADRALYRAKEAGRDEVIASAA
>A0A494IZG4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>V0Y7C4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 908525|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1C6DLS7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKECTEQDLRELARSAQAVFEAVTLTEAPLCDGWQDDGLRVDYELRNGRVDCVLHRRVE
ADGKCWELEMCAPLAGNVLPEERMTPRERELCREDMSHDFLTGVYNRRYLETVFAQKLEQ
CAAQGRKAAVALVSIDNGQKLRDTYGQPVMDQLHCFVGNQWKKSFDTPATRVVCRLTGSI
FAVGCLDADGKQLTEEMQNLYRQMPRECITTTGMMRRVPFTLSCGAAGLEDVSAKNWQAL
YELCDARLREAQNAGGDQMRAE
>A0A1C5L0I6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDLQLWIMINTASVIGLIYLFVFLYTNTSMEKKLKYNFYWIMGLELLELIFYNCELVTAG
LPYPTMHRILLSALGYTIRPVLAFMVLWCTMQRKISRKRGILLLIPLCLNALIAFSAFFT
DIAYSYSPDNRFIRGPLGYSSQIVTVFYLLLVIIFAIRNAKENPVMESAIIISTVTLIII
SMVLEAVIKVRFTGRAVIVLSTIFYYMYYQTQEYKEHMQEGQRLRTTLEKQSQTDGLTGL
LNKEAFKRAAENVLSSSEDVNMALVFFDMDNFKQVNDTYGHVAGDELLKKAADRMKSTFR
QEDLLGRFGGDEFYVLLHGITYQNLGRRLQLLIEDMHLKSEEGSLVTASVGCAFLAGGRQ
ADVEELIRIADEALYEAKEKGRNQYVIREVKNRGR
>A0A6N2ZPX7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGPQDLLDALDEIVYVSDPNTYELLYANRRCRSLLPTRDYKGKPCYALLQGQPAPCPYCT
NARLTPDKFYVWEFNNPSMGRHFLLKDKLIDWDGRPARLEIAVDITEQELLSRDTARKLE
TERTLVECIRRLMDAASSREAAQAVLSCVGGFYQASHAFLLELHASGRSVHCTQMWTAAD
AEPLELPSISLSNGSLLNRLLESPQAQCILAERLGPEYRQVAAQMQDAGVSALLFAPLPH
TFGRGLLGVANAASGINDTRVLESLAYFVGSELSRRRLQSRLEYQNRHDALTGLENRLQY
QRFLAGPIPAGPIGAVFCDINSLKQINDRYGHSRGDAVIMQTADVLRACFPGAHIYRMSG
DEFVVLCPGVTQARFETMLAKARDRLASETDYGVSLGGAWHACAREDLDELVRAADESMY
ADKQEHYGVPEHG
>A0A1C5NY33|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEHSIKAGLMITSASDYNMEICRGANEACKELGIELVIFFGGSVDPNVKFVQSSDYQKAN
VYAFANYLDLDFLVIPASSICRTDQKTREAFPKYFHIPIVTLNSQIKDYPFVVYNNKKAV
YDAVSYMIEKNHCQHIGIITGYDSGVTAKQRLAGYQEALSSHDMLFEEKYILSTPGYNID
SGNLMNKWLQENPELDGIMCVTDDIAYYLYRELEKIGKRVGKDIMVSGFDDKPESTHMVP
PLASCHADASFIAYLGIKQGYDLYKNGSTQNQYIDAHFIPRLSVDCENHEETEIGEFIRF
CRAEKESNEYIAQGMTQYVFDNKLVYSSNYQKTVWSFFTYLLDLSVKDCTKHRVYQQIGD
YINLIFNEDDIRYLDLERLFLCLSFLINTENYLNMEDKIKLQSFKQYIYLQMISSYNYLL
LLKEKRYTRRMRSIGQVNKGMLFESLNDDIYAIADNIPSLGIHNAQLYLFETPVMTYEFR
PFIMPKTMELIINVENGQRQPIKNTHVLLKDVLNLAKQPYKILTSIYSNENFYGFLVTDC
TYFDLETLEYLSNQIGISLNVNSIVRELNSISNTDELTHIYNRRGLIQNIKVLYKKYKEL
SKNLYFFIGDLDNLKYINDTFGHDQGDKAIQTVCEILNDIFQTHAVIGRLGGDEFGIAFT
CKNEDFIIQIDSLIQERTQYFNKKYHLPYYVSLSYGISVFDYNSPFDLNHTIRLADTLMY
ERKKEKHIQRGKKG
>A0A1C6KB29|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKKKLVFLAFATIAIALLLEAGILKYVNDSNTYRMSKVLLDRVITVLNKNDDSENGLIE
SLKDDYIVRAKAVSYIIDAKPQVEYDVEELQKIADLILVDEIHLFDKNGYIYSGTLPKYY
GFSFDSGEQMEYFKPMLKNKNLTMCQDVTPNTAEGKELMYAITWNEAGTRMIQIGIEPKR
LLKELKQNEISAVVSDMPVYKGIEIFVADSQTKIVKGATDSRQIGVKLEGLVVSSDKKSG
ETDVRLIRIGGKRCKCLLSQYDDYIVAVTIDSSFYRQGNIFAVLIVGVYLVLASCCMFYL
LSRVMKEKYEKEKLLYISNTDELTRCFNRHAYEERINNLDLREEWIYISLDLNNLKHTND
SLGHAAGDELICAAANCMRESFGKYGNVYRIGGDEFVVIITGNTKEFQSIIESFDRRVAQ
WHGKLVDSMTISWGYVFSSEKEWDNIYDIAKEADERMYKNKERYYQESKIVRRR
>A0A1C5KRF7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLE
ITGNQNDELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKEILKSLSREKER
LNSCENQLPIDYACGWALSSDDMACTMQMLLDDADAYMYKNKQLCKKYN
>A0A1C5NXQ1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSSEIMSLEMDVFCLLLLIRILYQMYINRVQNDHWNYFYYTIAWACVYLFMDAIWIMNVK
HFLTFSKIQSGIFNSFYFCSLAMLVCSWYVYVQKTLHSAVLKHKKILVLTFIPLIFFIGS
SLLSYWTHGLFVIDQAGNYHRGKLLPFYFLILFAYILYLSIKAGYLSKKAKNYLYQKEYK
VIVRFSFLPFITALIQITVDHLLIFNLGLTYSIFIVYNYFQQNLISLDPLTKINNREQLN
IYLTMKMKENHQKKDLYLFLLDIDQFKKINDKLGHVVGDQIILKTADILKQIAHLHNCFI
SRYGGDEFIMVCERDKNEEITPVFNNLQRLFQQSYEGLPDFSVSIGYAKYDESLNYIPKF
IEKADRYMYLNKNVKK
>A0A1C5SC60|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MCERRKLLMMKELLHTFFQHYLEDRNLNATLAMLSDQIVSIGTGEQEIAKNKEELTDLLK
KEFQEMPGSLHFQFTEYQETPVGSEGYCIFARIHVQFEEGDDLIEMDTRFTGVAGLEKDG
WKLLSLHMSTSNQVQEDQEFFPLRYGRQAIAKMSSESSARLMELVSKSLPGGIMGGYLEA
GFPLYTINDRMLEILGYTYEELAAATDEKMMNIIYEEDQKRVEESISQQFLNGNEYEIEY
RIVGKGGKLTWVNDIGKKIVTEDGREAMISIMTDISDRRAREKQLIQEAYYDPLTGLYNR
KKAISLYKEAFANGQKGTFFICDIDNFKSLNDTEGHIAGDHVLIFLARLISDRTKELAIS
ARLGGDEYMLFFPSPTETEEAVHLMKSIQTTFAAATKEAYPELSISLSVGGVVRKENEDF
RSLYRQADTALYLAKHQKGSLQI
>A0A1C5PQM6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDLWYNTNMKKKKVIILSSLIILFALVLEAGILTYANERNAYRTSTVLLDRVIAVLNKND
ETRGKLIQSLKEDYIVRAKSVSYILDAKPQVEYDIDELLTIADLMSIDEIHLFDESGCIY
SGTMPQYFGYSFDSGEQMAYFKPMLSDKELTMCQDVVPNTAEAKNMMYAITWNEDKTKMV
QVGIKPKRLLDEMRQNNVSSLVDDMPVYEGMKIFVAGTTDKTISGATDNSTIGKTLEEIG
ISTKDIHKNESKITDLFINGESYRCVMRQDENYIAIVAMEHTFYRQGTIYAILIVAIYLI
LASLCIIYMIFRVMREKFEKEKLFYTSTTDAITKCLNRRAYEEDIARLDPLEEWIYISLD
LNGLKHENDTYGHVAGDELICAAAGFMESSFHEYGKIYRIGGDEFVVIVTKHIHQFKEML
KEFDDSVANWHGELVKSMTISYGYVYSTEQEWETVYDIAKAADDRMYQSKEIFYTKNGSG
KRKVR
>A0A1C5MEA2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIAVICCVCMEVCDVIYRCERVGKLQEAMNQSKENLYWSSKIWGDITGIVIFVISIAAVS
TIYFSDRVRYLLKEHGIYVTDVIYADLVHLQIQFLIAMLALNFILILIILMVYRYMKYRE
YLGEMDPLTDVMGRRMFLHHCEMIQTGSRKDGPEKGWFLFLDVDWFKKINDTLGHMVGDK
TLQMVAQNLEHTFGKYGAVGRVGGDEFAVLIEKKMTRAQLEERLMQFEKAASAILTEEKV
SSSIGVYHFTFPQEIKHLLRETDNALYAAKERGRACFVVYEE
>A0A1C6I5V9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLLILLTAAAYFYFHSQYFLLLTDIGEIPRLRRGIVYLGFIVNYAYFIACSLLEFSLIFN
WFFFAFLLFLETLLYNKGNKIGSMFSTLLGIICGLAVNIFCRSVIAILLNLPLQNFDNRT
RDIGNLKGFPVMLGFVLAGAAMRIIRRPVLIGRIRLILKHRQNLSFILEMMAGLFFYLFL
NLLLYSTPLNDLLLKLWSIKSCLFCVVGFYIAIRYTWRICVLDDYREKNRQIERQLEEQK
REEEYLRHQAFLDTLTGLYNRQCAEETLASLMDQKSGFSLCFLDLDGLKNVNDRYGHEEG
DRYIRAAAEEIRRACRSGMDSLYRYGGDEFLALFVGMGAAAAEQRVDLINERLQKSASAG
EYPYTLSLSYGVVESTEFTDWKELIKTADGKMYEQKRRKQAVKCTYGGQS
>A0A1C5KJF1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRKNLEGKEIYKNYGIVIGIFLIAMMISILIFFGINGKKVRKNTEKELYAYVERQCFHLQ
SVLDVQYKYMEGLADYAGLQENLKDEENLNLIRSLQKQSYLEAVSIIDENGLSTYNTGEE
KDVSDRSYFQQVMKGEQTLSDPLISKLNGEQRVILCVPIYQNGVVKGALGGSYDLAYLGS
LVFEDLYDETGFQFLVTQNGDVISLDHSADDIVNPVETMLSTEDNFYSRCERLRFLGKVN
VDDLREDFEQQKSGLTEFEENETLYYMNYAPLSINQWMLCYVVPQKAALEKYSFIRRYEL
ILASVLFLLVVALFLVITAMNGRRQKALLYYARIDELTGIFNRRALENKVKSWIASEECA
GKQAFLMMDIDHFKEINDVYGHAVGDKVLKEVGKILKEQFRESDLLGRIGGDEFVAFMKN
VATEEIALKKARTLRDHISELDLPELKGKKITSSIGLAFWPDHGKSYKDIYVCADKALYE
TKRNGRNGCTVYRSFLEK
>A0A1C6CH40|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKIKDNVKSVYTQIIVLCEIFHISFLFIFKHFSMQIPLMYNIGSVIFYILMLFVVLKGYY
RVCIVLVHLEVSAFVTVTVLNGGYSLDFALYLIAMATFVYFNPFKHRSVTYIFSICEVIL
YIGLTLHCRHVYSEAEVQIVSVTIYNTVLAVGIILIGAYISDVSATVTHRKLVDENKTLN
NLANYDQLTGLQSRRMFMERIKDSEDNKSVVICIGDIDDFKKINDTYGHLCGDYVLQNIS
EIMRKSLGLENVDICRWGGEEFVFMFCNDDIDSAFVKVENLRKTIENKNFVYENNNISVT
MTFGIIERDSGKVDDVLLKSADKLLYRGKINGKNVVVKA
>A0A245ZEA0|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MEREPHRSADPAETSSVWLAAATLYFLLAASTIHLTSDGRGIATVWPANAVLVALLLIGP
RPRWLTVLSAGLVGNVAANWLTRGAISGPLFYSLANGLEVAIAVLLIRADQRRLELLRST
GRLLRFVLVAGVIAPTISGVIGAATAMLVYDQPFCTAFTTWVLSDALGLLVFTPFFFSTF
NGDFLACFASKSRRQRLEGAALMALTAATAGIVFFVAEQPAVFLLYAPIMLVTFRVGPLG
TKMAVMLVAVIGACATALGIGPVTMTSADPGVQAHLFQATLAVMLLTCLPVAAALAQRAR
LVEGLAAREQEAAQEAVTDPLTGVLNRRGFERAVAEAAAQPESSLSCVIIDLDRFKELND
RWGHQFGDRVLHHVAAMLRSNTRPGDLVGRLGGDEFALLLASAHAPADAVCTRIQAALRA
APLCPDGRTQVMVAMSCGVATRMAGEDFERMYRRADTALYRAKHAGRNTVRVA
>A0A2S8DFN2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQHETKMENQSWLKKIARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A0S4IEK5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MALDPPTMLTISIALAAAAALYLAIEWRSVRESSLLYWSAGFATITVGCTLALLRGVGLL
FIGIWFANGLLVVAHGLFLLGVLRFTQDRISRSWLVIVLIWFALLLLPAGPEWSKVMLMA
NSLLVAALTLKASSLLQPHGQSLSVGAVQLRYVLLVHGLFYVIKAIIAIAPGTLIDLASF
GGLIIQVSLVEGAMAIMMIALSMTGTVRYRREERIARLAARDPLTALYNRRALEVRAGPF
FKEVSNVRPAALLLIDIDNFKLVNDLHGHAAGDRLLVALSEMIRTVLPERSLAARLGGDE
FVILLSGASREGVLGLAKGLREQFQAYAGGAVPTPAAVTLSIGVNVFDQAPASLAALIEQ
GDAALYASKRAGRNSIRFVERQVASGGFS
>A0A0W1AML3|diguanylate cyclase|EC 2.7.7.65|Legionella waltersii|TrEMBL
MSDEQKAALFERSYYREKKAREEAEHLLENETRKLHLLNQDLEKKNSELTNTLKELELTQ
VELSRLAHYDLLTSLPNRLQFELDLNREIARSKRYNRHLALLSLDLDYFKNVNDRFGHDV
GDSLLREVAQRLKSSVREVDCIARLGGDEFAVILTEINNLAQAERVANTIIQLLGNTFLI
QGNTVFIGASIGIAYFPDTGDDAKTIHKNADIALYNAKACGRNNCQFFTPSLQKQYSKRL
GIGTALHLALERHEFFLVYQPRFDLKTNAMVGMEVLLRWQHPKRGVILPGEFISVAENFG
LIIPIGEWVLRTACKHYVD
>A0A1C5TID4|diguanylate cyclase|EC 2.7.7.65|uncultured Dorea sp|TrEMBL
MSSDYIMTMQQAQMEMELYKKVFTVVRLLDKREFRLEENDNPGGDMELCHCYDFWKKEKP
CKNCIAARAFEEKSVRTKLEYLDSDIYQVTARYVEIDGQPYVMELLRKMDEEFLVDLENR
DRLMDKLSGYNEKLYQDALTGVYNRRYYEDRIKKMTASVGVAMIDMDDFKIYNDTYGHNA
GDLALITTVEAIRRCIRKNTVVTEKDFANEEGEDGTALEALKVKQQILIVDDSEMNREIL
TEVLQNGECGAFNPVLLECLTDIQDHLKEVVNSDFVDNFDAEDNPELAGSHRSETENISV
GETVRKLG
>A0A526YBK7|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWASINLTYTAINVIEAVIGAVLLRKLLPWYNPLQN
LNDWIRLAIGSALVPPLVGGILVTFLVPGPEPLRNFIVWVLSESIGALALVPLGLLFKSH
YLLRHRDPRLLLETLVTMAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAHNPSALTTQHAGPMMNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLQPDIISWDKRMFELYEIPPHIKPTWQLWHDRML
PEDRAHAEQVLRDSLVSRLPFKLEFRIRVKEGVRHIRSLANRVLNKEGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGERGQLMENIHSGDISRSDIDQDVVLNCRTGGSFDIHYSITPLSTLDGHSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSMMLTLLRSSDVLARLGGDEFGLLLPDCNIESARYI
TGRLIHTINDYHFMWEGRLHRIGASAGITLIDEHNHLASEVMSQADIACYASKNSGRGIV
TVYEPQQERDLSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFGEFFRTSAAQVARKGMGVALPLSAAGLASVTLV
DELLDLLENSPMPGRLLHLVIAADAVCNPDENLQRGLQKLRQAGCRVIFSQIGRDMNVFS
HLSPNMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A5E7CRM7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENHRGKGLSFARRIYMPRAIGLGIGSLCVAVALYPLNMPMWVWVLMLLNAFVWPHVAFQ
LSRRSTFPYKAERRNLIYDSLCGGFWAATIQLNPLTTVTILSMMAMNNVATGGLRLFVLG
SLSQVAGVLISWLLFGMSFNPTTTPLQVWACLPILTLYPWAVGMVCYRLAIKLSEHKRTL
SALSRTDSLTGLLNHGAWKDLLQLKFQNCRQQQAPATIALIDIDHFKAINDTYGHIIGDS
VLRQLSVELKRNLRDSALAGRYGGDEFCVILPNIPLDQAREVMDRLRKVLHEYRHREVPE
LRVSLSIGLACFHPSYADSIAWLDDADKALYIAKNTGRNKVSVAASSADLDTPSALAV
>A0A0M7A9X2|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MNALRQFFVHSNGAWVASLTAVICFLAGIAVTAHVGYTVRSEIMSQNKRQAVANLSEVRA
KLEGELNRTVAYGIGLRANVIESSKEPFNARKYDAIASDLIDENPVIRSIGLAPDNILQA
VYPYQPNQSAIGLDYRLNTSQWPAIRQAMLSREIVIAGPLELVQGGRALLIRIPVFPPSE
LGQPMPERPYWGVLSLVVDEAGLMQAAGIADTVKQLRIGIVDKAASTPEKAHIFGSFGLM
DIDSVSLPLNLPGGLKWEVLGYPENGWNSNERSIWITQLVGSLISLLFGAMAFLLISEVY
KVRSMALHDPLTGLANRRLLEDRMLQLAVMSDRTGSGFEIFYVDLDAFKPINDNYGHAAG
DQLLVEIGHRLQQQTRQTDTVARVGGDEFIVLTPGNMRRLEREAFLERLGERLSEVFEFS
GVRIGVSASIGSASFPSDAGTIDDLLRVADSRMYSQKTKGRKKPETVSGNELPQTG
>A0A174NXI2|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MDSLELDRSKGSLLPHTVVSAKQNVYFFSPVHFRECEIGYLVLENCDYLLDHQFLFETLN
TFRTSIEALYGKLILRKKNKQLSQLYIHDSLTGLYNRMAYEKLALPLFQQYMQKGRPVGI
LFADADHLKYINDNFGHDMGNLAIWSIASVIQQQCPVGSISMRYGGDEFVCVIPDYSQSK
IQQLKESILASLEEFSSTSRTVFPLEASIGFVVADDPVFSLNDYINLADEKMYAEKKERK
ATRQ
>A0A448BPG6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNRRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYADPNQQLIARSI
SYTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGQTLASWHRESTGPLHLLEQQL
AHWLLSAPTEQPILHDGQKIGSVEVKGSGGSLLRFLLTGFAGMVLCLLLTALGAFYLSRR
LVRGIVGPLDQLAKVAHTVRRERDFEKRVPEAGIAELSQLGEDFNALLDELESWQARLQD
ENASLAHQAHHDSLTSLPNRAFFEGRLSRALRDANEHREQLAVLFIDSDRFKEINDRLGH
AAGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGADALRIADNIIASMQAPI
RLSDGSTVSTSLTIGIALYPEHADTPAALLHDADMAMYIAKRQARGSRRLAELNDPRILQ
EEKEIDSATPEAPPK
>A0A5E6T9D8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRQGKGLSFAKRIYRPRIIGSALCSISVIAALYPMTAPGWIWAALLANGFVWPHLAYQ
LATRAKVPYDAERRNLVYDALFSGFWAATLQFAPLTTVTLLSMVSMNNVAAGGKRLLLRG
ALAQLLGAGVAVLLFGLHFNPSVSLVQVYACLPMLTFYPMAIGMICYQLAIKLSDHKRAL
SALSRIDSLTGLLNHGSWKDLLHLKFHKCQQQHTHATIALIDIDHFKQINDCHGHIVGDA
VLRQLSLELRRNLRENDLAGRYGGDEFCVILPQMTQHEAARVMERMRETFSNYRAPNIPE
LRVSLSIGLADFQPSFKDAAMWLNAADRALYAAKDTGRNRVNMSDERVAYSA
>A0A174F7M5|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKRFDDKNGTDDKKKRKRILFMAGMIAVIIITAALFYFNSFVMKTENSRARDSLLEWTEQ
NAALVGSRIDMYYDLLECAADYISDMPLDEVQTEEMLREKFHRHTEKFDSLKIISEDGRC
VQDGQAYSLKEYFLMAMLGNRGLAENGYSYADGVILSVPVKNEAQQIKGVLCGTLPCSSL
DVYGKADRRKGYAGLFVIDNHGKYIVPDGGNDTFGNDFLTWLERRELSLPISDIKSQMDS
GFQYYFAISDEDGDYMVTVAPVDGTKLFAVTMADNRYIHQAGLRYRIWVFVITLVIILSL
IAVTGVYLYFRREDRIAIRNLNRQLMLNEETYRITARESDLCVFTYDVETEQIQFLNDKY
QNLGLDQSELSVPVLLRKIREINPETCSVIRDIFARVDSAEALHSQKVKVWAGGRMRYLQ
VKTTNLYDESGKVSRMVGSIEDVTDMENDMLKLQKEARTDLLTGAMNRAAGTSAINRMLV
QELHPGCVNTFAIVDLDNFKTLNDVMGHMWGDRALCEVVLIMKKHCRAQDIVCRLGGDEF
VVFLPDMTREAAEESLRVLSAKLHIDYVKENLEVMISASMGIVFSDGRDITFQDLYEEAD
GCLYQVKRTFKGSYHISDRAGRVKAD
>A0A109KVI9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNSLGQDQGQQIEEQVRTDRLHQLFRQSFSAIFGSYLGAVMLCWLCWDRFDHQVILVWLV
LLAGSTLVRLHLFVQWFRCPDAGRTPARWERRYWVTLMLSAGIWGGGALAVMPVDDRLSQ
VLVMLFTVGMSVSAVSCYSAYRYMTLGSMALVLLPCTVWMLLQPSPMQVGVALAVLVFAS
FVAGATRKLSDALEKAFRLTRQMERAHHISTRAAQTDELTGLMNRRAFYEQAQLLYAQCL
REQQPLCALMMDMDHFKAINDTYGHQAGDQVLRQIGAVISASFRQTDIYGRLGGEEFAVL
LPNTSLETARGIAEQLIQKIGDLPADPVQGVSASLGVASTHAQHLDLNGLMNSADKALYQ
AKASGRNQVAVVD
>A0A5C5Z628|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MSLTGGAGKERMLVFQWGVLETKSGFSFVTPHHAIVDLEGHVLNTLDRFHGFTNFDAASK
KALRYLHENYGFALWMVTRTEGDDWIVLQVEDHGYEVKSGDVFRWADSFCSQMVLGNGPC
IAPDSQVIPAYANALIGTQVSIAAYVGLPLTRPDGSLFGTLCAIDPSVQPDNIVNALPQF
ELIAQLLTTILELEIHSENEVRRAERAEAIAESDPLTGLFNRRGWDRLLKAEESRCRRLG
HPASIISIDLDELKQINDCYGHGKGDELLVKAAELIRSNSREYDTAARLGGDEFSILVIH
DQDQEALSLSDRLRESFTLEGLNASIGVGRRKPNGSLQEAWQCSDASMYEQKRSRKKQSQ
QIS
>A0A563VWX5|diguanylate cyclase|EC 2.7.7.65|Hyella patelloides LEGE 07179|TrEMBL
MNTNSPYQFLQPEDVIEVAPPTVDSQMRVIEALAKMNQKEPNQSTYRRYSYVLVVEKLQL
VGIITERDIVKLTSAETNLVETKVDAVMTKQLITLKKSEFLDVQTILAILRQKKIRHLPI
VDAHGQLEGIVTVNTISRALHPSNMLKFRRVDEAMTLQVLEAPETSSVLSLSQMMADNRS
SCVVIVSPQQPEEVTELAERDLSSLSIPVGIVTERDIVQFQILGLDLINTIAQTVMSTPL
VCVKTTDSLMQVHQQMDSLRVRRLVVIGKQGELQGIINQYDMLKVLDPAELFGIIGTLQQ
ELEEKTNQLQQEKELAQVTLQSIGDAVITTDVMGKIVNFNPMAERLTGWRISEAKHQPLT
DIFRIINEHTREPVPNPVEKVLRENRVFGLANHTILIARDETEYSIENSAAPIRDRLGRI
IGTVIVFHDVTESRDLTNQLSWQATHDALTCLYNRREFEKKVAEAIAIAQNEGHQHALCY
LDLDRFKIVNDTCGHAAGDELLRQVTQLLNQRIRSADILARLGGDEFGFLLYQCPLEVAT
KIANNLRQWIEDFHFTWEGQAFAIGVSIGLVEINSNTENLSSLLNAADAACYAAKANGRN
CVHVYQDNDAELAKNLGERQWIIRLNQALSENRFCLYSQKIVSIKDEEEVDRYEILLRLR
DEQGQVITAGAFIPAAERYDLMPAIDRWVINHFLADYERHYQQGGEPKKAQSNSLYAINL
SGASISSQSFRLFLKEQFTRFQIAPSTICFEITETVAISNLATAAKFIQELKELGCSIAL
DDFGSGMSSLNYLKNLSVDYLKIDGSFVKNIVEERVDRATVEYFNQIAQIMQIKTVAEFV
EDKAILQKLQEIGIDYAQGYGIARPIPLVLG
>A0A517ZXP0|diguanylate cyclase|EC 2.7.7.65|Symmachiella dynata|TrEMBL
MMNVTEVPAPSNSNSQQYLTDSSQVLLGLLTLSDNCVAHPRTTDDDTGDVIARPALTSLL
SALHYRDVATVEHARRVAMLALGMASQIGWEDRELKVLEVAALLHDIGKIGVPDSILFKP
SSLSPEEAELMSLHYYIANDVLQAYHVDPEVLEIVSQCHEHYDRVGYDSQRVGSDVHMGA
RILAVADAYDSLATEQVYRKAKPHDEIMQILMLGAGTQFDGNIICSLSRWVEDGRVPTGM
HLNSKGLLPSEVSEREFRGDSENAGALCHIFAYLHLLENLYDGFYLMNSDQRFVVWNRRA
EDLLGHRPHHMLNNVWSNKTLGYCNEKGKPLADKKCPLFQALAERKPVTTTLPVRHRSGE
LVEVEVQTVPLIDSEGILKGVAEIFRNTSRQGGKTQQYRELKEAASRDSLTQTANRGEME
RQLEQTLAEATNGQTAETFCVIFIDADHFKSINDDFGHTVGDDVLVELAKLLQNETYSGE
LVARYGGEEFVVICPATDLDQGYKRAERLRIAVSKLKIADLKGRKLTASLGIAVNEPGDT
VTDLLSRADKALYEAKGAGRNTTRAYANKELDIQCQLENAQKEAKEAEAFMYKGTFHAVI
ASDMLVYKLAGFVDDYQSKILEVTPERVVMRLGNRGVIPGWGNHDGRRPVTIEVVIGKEE
VQEPGKTRARAKRVEILVTISPVGWIRKKDVFQHRAAGVFKDLKSYFIADMDLSP
>A0A0U3RT49|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii XBB1|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFSRKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A4R8SC85|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MQNRQQLEPGFQYLLVTDALRGAGQLRQLKVGIGLLCFSIVVLAGATQFIPLGPQGVWPR
TIQAVAAAMAVIVGLCWILFPWPSRRGMVAFVAWADVTLAITAATFSDPTARLSAVVYLG
LVGLLPTFFLGRYALVAHCGFAVALFGALVTMNVLVDGATWFSQFTYGAPTLAAVVLMPT
IIQLVLEGGRDSILAAAVSANRDPLTGLLNRRGVTTAIDLLHRGRIDAVDVVVVLMDVDG
LKELNDTRGHGAGDAMLKAVAAMLTASTRVGEIAARIGGDEFLVVAFPGRAENIDTTIRR
VSTPRAGIDTWSVSVGAAWQSQTGGKVDLDSLVQQADYELYKVKSSRGMLDPQH
>A0A172Y8P4|diguanylate cyclase|EC 2.7.7.65|Brevundimonas naejangsanensis|TrEMBL
MQLSSDPQGGVLSRAGDAASLGRLRQRVEDHADALVAAFYDALLADEEARSFLHHSVVQE
RLSPSLRRWLVDLFAPGADLAGAAFAARQQKIGEVHARIKIPMHLVMAGAAVLKGRLADA
LASDPAAFDLLRLAGERIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERESQR
AGLMEWSQKTLFRILASGGVEGAGALSASPFGLWIRHRADFLFDGSPHLTRLNAAMERID
AELLPRFTPGAASSDLAGPLEALEAAVDEVAFLLNEMFQGLAGMEGGRDPLTRALNRRFL
SSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPIGDEVLRQVAEAVTENVRPSDF
VFRYGGEEFLIVLVETSLRQAATIAERMRQALATKAITASGLEPFHVTVSIGAAEHGGHP
DENYLVKEADDALYRAKQNGRNRVEIA
>A0A702B394|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eastbourne|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5W3F1W2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7T1F288|diguanylate cyclase|EC 2.7.7.65|Atribacter laminatus|TrEMBL
MEIDIRTLSLVNSITAVIQVIALTLQYILVKTYRGIGWWLIGFLMFALGFLFAPLRDISQ
ISQISQISIFFHNLTLILGIVFLYIGLLRFLNLKENKKIIIFILVSYIFLFTFFLYIQDD
ITARTVIFSSFSALLMFSISFRLLKNLDKSLKTSQLFVMTIFFIQGCFLLFRTFAVITIS
PVSDFFAPTLTQSLTFLSYIIIGNLFTFGFIIMVNQRLNIDMKEAKEHFELIFNTSPDAA
IISRIDNGKIVSVNNGFTNLTDYNREEIIGKSIHKLNIWKNLADRRKLIDEVLKNGFCNN
FESEFLKKDGTQIFGIVSAKTMILHSIPHILSVTRDITIRKNALEALKKSEERYHSLFEN
MIDGYAYCEMVYGKQNQPVDFIYLEVNKAFERLTGLQNVAGKPVSEVIPGILDMNPELLD
TYSRVALSGESESFEVFFKPLNIWLDISVYSPSKNYFVAVFENITDRKKAEEELQYLASI
DGLTGIYNRLFFIKACENELIRFHRYGKTFTFLMMDIDNFKSINDQYGHLSGDQVLQSFV
KTIGKEIRNVDTLGRLGGEEFGILFIETTVKEGLKTAKRIQNALENTEIQLNSDQSITTK
VSMGLTEVNSEDTNFDSIISRADQALYKAKKLGKNRIEVSE
>A0A7V8PLY6|diguanylate cyclase|EC 2.7.7.65|Pectobacterium sp. CFBP8739|TrEMBL
MPASPPAFLTVDVRRSGLRFSQRVYIPRIVGTILCSLFISSVLITRPIPTLLWGLLFLNT
FIWPHIAYLLSLRSRDPMRCEKRNLLFDVMFGGIWIGFMGVNLLPSAVIVAMVGMNGTAG
GGIKLFVQGLVLQCVACVLVLVLFAVPVSLDTTPIQIYACLPMLLVYPIFLGYVTYATAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDSCQRYKHTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKAADMALYRAKNKGRRRTEVA
>A0A1S9CXX7|diguanylate cyclase|EC 2.7.7.65|Chromatiales bacterium USCg_Taylor|TrEMBL
MYLVIRYIAYVGLGVHIICVPLFFVLGVPVLAVFNIFSSVAWFVGYLANRRNNHALAITL
LTTEVVAHTIVAVYCVGWHAGFQNYLMAAISFTMFNRALKTKLIVLECIGIGALYCALYA
LSIRAPNPTLAPALLETLYYANAVVTFAALAMMTYFFRQASARAEQRIKELADTDPLTQL
PNRRKIEELLETERLRCERSGRPFFLVLADIDHFKTINDSHGHDCGDAVLRRVASVMRRT
VRKIDIVGRWGGEEFLIVLPEISLEHAIEVVERLRRGIEAAYLDFAGTRHSVTVTFGMTR
YDQDRPLELCVKQADDALYRGKQQGRNTVIVVEPA
>I6E102|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDV
GPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLI
FLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTG
LYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVL
DGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGSYLCLFDVDKFKNI
NDTFGHLLGDEVLMKVVKILKSQIPVDKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVH
FQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A8H9CDZ3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKEPDVLKAYQAKEGELKNIEHKVGQLKDTGATGEELALLYEGLKIVDGLQD
EQQAAIASVARGEEQQAIALLFGKIYELETERAQSKIDHFRMLLDKRIIADVQAATNTSK
TLRTASEVMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPNFNQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVIEVAELFAP
NIAPGIAGRLYIMDRNPWEMRCAAEWLSPQGEKNAFHPDQCWAIRRGQSHPPVNGEPDIG
CQHLPESQKDSSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQIAQAMRNDEPVSCMMIDIDHFKSINDRFGHEA
GDHVIKSVATIVQRAVHDAGLAFRFGGEEFLVLLTGADEEAAHACATEIYNGVHTLSLRY
GLAEIGPVDVSIGIASYPQHAQSDDLLRAADVALYRAKELGRSRIVSFSMLETG
>A0A100JFT6|diguanylate cyclase|EC 2.7.7.65|Streptomyces acidiscabies|TrEMBL
MSEVLFAAAAGLPLAAGWSVHALLLGRRIEAARRDPLTGLWTRDAFEDRARKLLAKGEGR
AVLLLDLDGFKEINDTFGHAAGDAVIRATGMRLGAWAAGYGGVAGRLGGDEFAAVVDAGE
GLGGRVLELVAGIERPVLSQGRPVDVSVSVGVARWPRRGGDLSTLLRVADERMYEAKREG
GGAWIAPDAVSVLPTVNGRRFGRPGTTGREAVR
>A0A144C5C1|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MLANRRSLKSRYIAFCLGCIAVIGILQTLFLKLVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMTMKYWCDRKRLYLVAIAFAFAGSALLMVGTLSSFPAWLDLYQFNVVNYNDAMIYYMF
RHLLMAVLIIVAAILYTTRNYPLSRLAHIAIVSGEFLFTACAVGLAWIYSSHSPLLSIDL
VDNETRQFMVLWSQFINVSLIALWVVTLAALMFITRVRNLFWVGGNFLCVCYIVTLSMLL
VGGHAEDISWYRARLFETVATLLLIFVLLYDVFRLYRDSHVKYQQSYQNSIRDPLTRLYN
RSYFYESLKQALDIANPGRPVSVIVSDLDRFKRINDTYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLTNTSSDAAYHVAERIRLHLSSFDKTSSDGQLPEPITISMGVFTA
TSPTITAEVCVESADKAMYEAKETGRNRVVVFK
>A0A840FQV2|diguanylate cyclase|EC 2.7.7.65|Variovorax guangxiensis|TrEMBL
MEFLIEQLSETVSSATTLEDLARPMLEMLEAATGLESAYLTVIEPDKARQRILFAHNAGE
LTIPEGAYVPWGDTLCRHALEEDRIYADDAGGCWGDADAARELGIQTCASAPVRLDGGGL
HGALCAASARQMPLPAIAEPVLRLFAKLIAQQVDREQMVARLDKAGIELSANAATDVLTG
LPNRRALVDALQRMLAQGARSAQSVLVGFIDMDDFKKINDAHGHAVGDEFLAAMAKQLSN
CVRASDMLARFGSDEFVVIGLGPGLGESPRTGAMALGDRLAENTKGELRLRNLTIDYAGA
SVGVVAVDPRTTSAEEALRQADAAMYAVKHGRRTMFQHAGEALSD
>A0A4Q4A0X4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESISITYTAINIIEATIGALLLRKLLPWYNPLQN
LNDWVRLALGSAVVPPLVGGILVHFLVPSAEPLRNFLFWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLEQLIHGEINTYSLEKRYYTRNGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPAHIKPSWQLWHDAIV
PEDRANAERVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNITFMNPVAEKMSGWSQSEALGQPV
LEVLHITFGEKGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLDGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINSYHFSWEGRLHRIGASAGITLIDDSNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLGEAELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
NELLDLITKGPLPARLLHLAIAVDVLNNTDENVQQGLQKLRHAGCRVVLTRVGRDMNVFS
QLSATTADYLLLDADVVTNVHGNLMDEMMVTIIQGHARRLGLKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A8J7S3J7|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MNKREQGCQPADQSRPEDLDANDVLAAVDDALDEHARWLNRWHRALVCRIEPEPDLLDED
RVLYSRFGMWYLAHADDPLLRQSAVSELWKSYRSLHELARLLAERARADRPVPVGEYDEL
VARADAFRGRARRLRDAFGKAVSTLDPLTGLSTRAGMMAEVETAYRRGTDTGHGGKGLAI
GLCDIDHFKAINDAHGHGVGDEVLRAVAGRFVSRLRPTDTIYRYGGEEFLVCLPNAGEET
ARDVLERLRRALEERPIGLDKGGAIEVRASFGLAVADRAAPLKTVIERADEALYRSKDTG
RNRITCWRPGLSSDLSPEFSKEGGRSMR
>A0A6N3EDQ2|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MVETMLLFLILPNMACVIQLLKIPTNQTEIIIYRDKKMKRKKRKFAINVMSLAVIPILIL
GMFVIFITSSLIYTALKGEVANNLEDLARVSYQDFDMQYPGDYYLNNNHLYKGTEDIQND
FNLVDLIKNNTGVDATLFYQDKRILTTIRQEDGKRVVDTIAPDEVIETVLNNDKEFFSDS
VVINDSSYFGFYMPVKNTDQHVVGMLFMGRPRADVMNHIMHNIYLVSLSIVTIMIIAIIV
SYYYSKKTIFALNTTKHFLGAVANGDLTTEIDPYVLQRHDEIGDMGRFAVMMKESLSDLV
GKDPLTGLHNRHSCDVVLASLIQRVKQKNTSFAVAMGDVDFFKYVNDTYGHQAGDETLRQ
LAKVISTHMEHLGFVFRWGGEEFVLIYEDMDRYQAFKHLEILQEQIDQESIYWKDDKVKI
TMTFGLADSNEYNDLDELINLIDDNLYRGKKEGRNRIVFNTLK
>A0A6N3BML3|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MFIYIIIRIISSTQDAPIYIISDKNIILTLSIFNAVCCFIVMIYSVFISDVSSKAIDKLN
ENLQEIADNDQLTGLRTRHYLFDSLNSSPNLDCNIVIGDIDDYKIINDTYGHLCGDYVLH
SLANLMKDKIPDDIDICRWGGEEFVFLCFNTNKEELTYVIERFNNLLRQHSFIYEGNVIK
ITMTFGISDTMKAKHLNTMIKCADDRLYKGKRCGKDQIIVDDKK
>A0A7Z7VTB7|diguanylate cyclase|EC 2.7.7.65|Staphylococcus agnetis|TrEMBL
MIEAIIYNISVSIAGIYLFHRLQYAESHDFRFSKSYITVLMTIVGLLLALYPVPIETYHI
QLSFVPLLFLGRYTNAFYTFISALLIATVSYFVLATPLIFAITLLMIAIVVSTIGPFIRQ
NHIIAIQILNIITIVLLCIIAIFVPSFDIIEVFYLLPLSIIATLITALFYVDLHRFFTLI
DRYDNESKIDYLTGLGNVKEFDRHLNALTQRAEAKKQSLALILIDIDGFKDVNDAHSHEA
GDAILKQISHLLQNYVPPKHKIFRNGGEEFSIVIKNYSLDECVKLAESIRKGVEKSNFHL
PNKSVIKLSVSIGVGYLTNEDYKSQRKVFKDADDMLHIAKNEGRNKVMFNPIIKLK
>A0A484UPF9|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSASTELLATTWRRAQARHEPRTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIALNARYDEAVAFQRHIGEVHARIGVPSHLVMQGARALM
MDLHALLADAPAAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENAFVYEVAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCATIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQTASHLSVLSIDIDHFKGINDQHGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQATAIGEKLRRRAEHERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADAALYGAKRAGRNRVLAHSAL
>A0A7Y8XGV4|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MDLSATQHPLKAKGVLFTHSLLSALIVFLLAYLCLTLSAESSHFTPLWFPTAAVIMLMFH
QPPRNWPLHLILCGIGMCIASFLLFGLSWFPVKLTLINLLEATVCTLLLRRILQPDDPLN
GLASWLKFVFCAVIFTPMFSALLAATLAPAPGETFWHPFSTWFISEAIGVLALAPIGLVY
RRSMLRTLNLFELLLVLLGTLTFSYLALLNLPFPFTFIILPLLWAAISLPRLEAFIICFT
TTLMITVMISLGLLHFQDRGTFLSDVTVYLPLMLILIPAHAMAMVMHAFRVEKEHIVESE
TRFRNALEYSAIGMALVSPEGKWLQVNQALCKLLRYPPETLRRLTFQEITHPDDLNADLT
QLQDLLDGHISSYTMEKRFIRSDGESVWTLLAVSLVRDPQGQPLYFISQVEDINELKRTE
AENRSLVERITLANQAGGIGVWEWMLNGDKLTWDKRMFELYELTPDQTPTLALWNSLLLE
EDRERIGRQLATLSDRHQPFVMEFRIKTRLGGIRHIRGQGNTIFDEHGESKRMIGTNIDM
TEIKSLAEALHEEKERLHITLDAIGEGVISTDREMRITFMNPVAEQMCGWPLELALGMPI
NGVVRMTDGQDGPEIENPVKNCLQEGPPLPAEYALVLHSRDGRRFDVQESASPLKTIEGE
VMGAVMVLQDVSASRELMKKLSYNASHDALTDLKNRTSFEKRLKNAIASVAENQQQHSLV
FLDLDRFKAVNDSAGHAAGDALLREIGQLMQRQLRNSDCLARLGGDEFGLILFDCSLEQA
KQLMQQMIEQIGEHSFCWAGKIYHVGASAGITQIGATSGKSSELLAQADIACYTAKHQGR
GQVYIYEARQKQQMERQHELLTRQEVLNIIDNQQLLLRVRAASPPKTPQAVCFYQLKLHV
RPSDDRMLASESFLAAAQLYGLLPDVDRWLVSQVLERHAEALRRKGLVIALPLATDSVLD
LDFQNNFLALLAASVLPASALYLMVDETIVLDHPEDDGAFIRRLQQMGCKLIVNGFGRNL
NAFDQLNGQTIDYIRIDERFITDVHCNQMDELMVSIIHGAAHRNNTQTLAGPAHQQVTLS
ALTAIGVDLVDGDTVALELPLSELLSGGYFGIH
>A0A4V6KMT1|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MIPHGHAIGDHVLAAFAHILRRELRHDQLFGRLGGEEFAIMLPRALGTQAVALGEHLRRR
IESAELNPNGKAPLRITISVGVASLAMNEDKSLEQLMNMADIALYRAKSQGRNCVESFNM
VSGNSLNHVIFK
>A0A1V4IM54|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MGKIECIEIDVFALVILFVIFVNTYNRPGRHLFEQKLFSILLYSNFGVLCSDAILWGLNG
MPNENIRILAGILTVIYYIFNILPCIVWSIYAHYQVYRDEKASLVLLMLISPPAVFGTLI
CAASYFNGLVFYFDSDNRYFRGNLYPVIAFICLSYLLFSLVLISVKRKSLEKNYFTAMII
FIVPPFIGGVIQYLFYGISLVWICTTVSILIIFINIQNNQLYTDHLTGLYNRRQLDYYFH
SIKRRKKRKKLLAGIMIDLDCFKQINDKWGHGTGDAALVDVGEILNKSFGKSDLVCRFGG
DEFIAIMEINQESELLAAIKRIRINTAEIKNKRHSSYNISLSIGYDIYDWDSEISIDDFI
EHIDSLMYEDKRNA
>A0A851GAK6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SECR19-1250|TrEMBL
MNKQHQRVLVTTPHPLMRLVCLGLVTFIFTLFSLELTRFGALLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWSSINPTYTAINVVEAVVGALLLRKLLPWYNPLQN
LNDWIRLAIGSALIPPLVGGVLVHLLIPSPEPLRNFLVWVLSEAVGALALVPLGLLFKPH
YLLRHRDPKLLLETLVTMAVTLVLSWAAIVWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAHNPEALTTQHTGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIDGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRSGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRESLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGEKGPLMENIHSGDMSRSDIEQDVVLNCRTGGVFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLVHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNNGRGVV
TVYEPQQERAHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSEFFRAYAAPVAKKGLGVALPLSAAGLASTTLI
DELLDLLDKGPLPGRLLHLVIAIDVVASPDPNVQTGLQKLRHAGCRVVLSQAGRNMELFN
HLGANVADYLMLDAEVVTNVHGNLMDEMMVTIIQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGVDFIFGDTIGEPQPLDLLLNTSYFAIN
>A0A1Y5RJ92|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MTFSILNNAPRQPLNYIRLAIRARFIAAAAMIGCAGVGLWASFLGINIALQPLEGGAATH
PLTAVCLIALGVCILKAQRYGAAPFWQVAVLGTIVAICAARLMDAVLTGSTGTTSIGILG
AVDGFSGRFSVEAAGAIGGFAMAMLLRQTSARLGALFMVLGVVIVHSTILQLSYGVVFFG
GDVGSFTFLGLAAVSVAMVSVYLNRPFVRIAFAKGGAGAQTRIMLTTIVFVPWAAGIVLL
VSGSVADGVVMATVIASVTLIMAAVLMCTIAYHENATTAKRRAELELAMMSRIDAATGAL
NRFGVTERVEAAWLDFRTTAAQFGVIMMDLDYFRRLDATFGAGEGEGVLARVAQTLDIHL
RDSDAFGRWGSNEFLLVLPVGDVRHLEIVATRLRAALANPENPLCEGFAMMPATMEVPLG
ISAMTDKDDAPTDAIVRADVNLHTAKADEASTVPVLSVEQEDMFIFAGDTVAAFDADAAA
DSVEASDDDIEMPKKVAGRRAA
>A0A0U5MP09|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MPSSVAAVAGTGKVSVDHELLELVSALVCILRQGEVVFINQAGVKVLGLGSQDDAIGTAF
VEFVEADYRFLVEAGWELLAEEEFLPLKLMRRDGTLFEAEIRVRLIPGPEESFLVEARDI
SKFVKSAEALREREERLQGVLASVAEGIITVDEHGLIETANPAAERMFGHPKGKLVGKHI
GVLMGPDMQDQHQALFAQYLAGSAKLMGRSVESMGYRADGTHFPMEISVSELRYGKGRLF
TSILRDISERKENEERIKRLAHHDTLTGLPNRNLLNDRISHALARVRRHGGRMAVLYVDL
DKFKPINDTLGHEAGDAVLREVARRLNNCVRSSDTVSRVGGDEFVVVVEEIGRPGEAAMV
ARKIIETLGSPIFYNEHACQVGASIGIAVFPDDGNTMDEVSKAADVAMYRVKHSGRNGYC
FYSDAMPADEIDLAEAPAGG
>A0A1Y5RQC8|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MRKPMSKLSFLLIPWSGVFAAAFITTVGAVLLANSVLPFFYDGEILAETQRMTPFVTSIT
AFPFCCFVWAQVRYNILLGLELRNLVERDRLTDVATRDYFFSKLKSRPDSYGVSLMVDID
HFKSVNDTYGHLAGDDVIVAVADVMRDTVRENDIVCRFGGEEFVVFLDRADKAAGAKIAE
RIRADVAARVTQTGVGPVRVTVSVGGSLKEELENIEQTIQRADEALYQAKSLGRNRTVMD
WDKQMAA
>A0A0U5MI51|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MSAIRIMVVEDERIVALHLRHQLLKLGYDVVFIASSGEQVLRQIEGLRPDVILMDIHIEG
DLDGIETVARLPAELHIPVIYLTAYSEEAILTRARATKPFGFLLKPFSERELHATIQMAL
ERRNVEEALRDSEEHLTLALDAAGMGAWEVDAQSRRIVRAGHIERVFGCVGQGFGGSLDR
FLDHVVEDDRVVLARAYERLLNETAPLQVEFRGIRPDGTVRWLRAQGKAIPSRAERPQRI
IGVLQDVSDHKAAEDRQRQALTVFEATRDGLLILDPLLRVVTVNPGYCAITGYDEADLLG
RRPHMLEVGAQPTDLHDEIMEALKEGGRWRGEIAARNRDGGILPLLMNIAAVRSEHDSVV
HYVAAFTDLTAIRAAEERLQHLAHYDPLTDLPNRLLAGDRLDHAMERGRRDRKTLAVLFV
DLDYFKRINDTLGHSVGDVVLKTVAQRMRGAVRAEDTVARLGGDEFMVILEQAENPDDIA
AVAMKIRAAVKQPLMVNGRELATSASIGISLFPEDGQTREALIQAADTAMYAAKETGRNG
YAFYTREMTERVIQAVASDSDVRRALAADELVLFYQPQISLESGEVEGVEALIRWNHPEQ
GLLGPAQIIPPAERGGFIIDIGDWVVAEACRQIRKWQEAGLPSFRVAVNASAQQMRNGRL
LRAVQDALAETGISPDMLEIEITESMLQNEDECIATLHALKQLGVTLAIDDFGTGYSCLS
SLKSLPIQRLKIDRAFIEGIPGDINDVAIAEAIVAMAHRLRLSVVAEGVETEAHMEFLRT
VGCEGVQGFFHARPMPAGEVPAFIIGRSPPG
>A0A839VND8|diguanylate cyclase|EC 2.7.7.65|Herbaspirillum sp. Sphag64|TrEMBL
MPTRQPHSQNHSNRIRLQSLLSLLSLAHFRQALGDASAPDELIGKGVRFAARIYRLRMIG
LSIGFFCVAAAFVQNPVPWPLWVLLFFHGYLWPHLAYHLALRNIVPYRAERRNLVADTIF
GGFWVIAMQGNLVPSTLILAMLSMDNIAAGGLKLFLRGLIGSVVGALLGLLLLDFHFQPL
SDLYTIVACMPMLALYPLALGKSTYDMSKKLAERSRAFETVSQRDGLTGLLNRRYWETLL
IEEFEASHHQQRNSCLLLLDLDHFKSINDNYGHLVGDAVLKNFSSLLQQHLRAEDLIGRY
GGEEFVAILRNVDLSEAIAITERLLHQVRLCRGQENSLWGCTISAGLVPFQPDLEAHYSW
LQRADNAMYQAKGRGRDCLVVDGGKETGARIGCQQ
>A0A3Q9E7A5|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MQSAHLARTKLWILAFAIVYWLLSLLTVEYLHRSYVRDYLAEQQQWFSQKLALIRANIEA
KVNADILLADSLATILSFNPDMPYSQWTVLAELMAGKGEFIRSVSIAPNDVVAMVYPLQG
NETVMGLDFRLLPTQAQAVVEARMSRQITLDGPLTLVQGGTGLIARAPVFSNPPLNSHYW
GVCSVVIDLDQLIAQMRSTELAEGTTLAIRPLSYPDTTGAPFIGVVEDFAAAKATARVHL
LGATWELALADRRELRAWGWQNAARLLGYSVALLLFLSFLMVANAYRMAHLVSLHDMLTG
LPNRRFAMALLSKLIQTPNGRFVVVNVDLNHFKQVNDNFGHAAGDAMLKAVAMRMQSGLR
SSDIVARLGGDEFLLILPRLTEPEDIERVLAKIRQAACEQPLELEELTLTISISMGQARY
PEDGLDISALLHDADKAMYTDKQRIKGEHQ
>A0A3S9L2A5|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MKQRDSLKRKRIDSLGLGYHLTLLLIPLSVFIGIFYLFSPKGSLPWMILTLVCLVYLVGY
SLSYYLHQGRLQRLWEHLEQVVNINDATFELVHLSSQYKDEHAFLDALLTKAVNVINGAE
MGSIIRVEPDSHKLMFESSVGLDLERLRQIDFSLEQSFEYRLTDGRCDRVVVVDDMRHVN
AESTLTKAEQEILLTAAHQPIRSTLSSPIHIDGKLYAMLNLDSSQLSAFSDYDRNLVAIL
THEAANAISLYQKSREIYRLANFDALTGLFNRRHFEDSLAQWKHNRAFGSFLTLIDMDNL
KTINDIMGHQAGDEALAQLASALKQHWPQSSLISRFGGDEFAIISHGPEDALQERLNKLQ
AALAALDKPISVSAGVAPFTGQFAQSFKLADERMYEHKRARKLSRTQASQ
>A0A0U1HWJ1|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MNSTKNKSAERNQAQAVKLPTLGRVLGKIHLTVAIVSVVTAGIFLTLAALFALRVYAEHN
LHLIARSISYTTEAAVVFGDTMAANESLALIAKNEEVEQAKILDKNGREVASWTLPESGP
LHFLERSAARWALPEPVVVPVIHSGNEIGKIIIAGHGGSLLRFLLQGLAGLLVCLILSCV
VALYLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSNDFNGLLEELE
VWQRNLTLENDSLAHRAAHDSLTGLANRAFFEGRLIRTLKECKSKEHAAVLFLDGDRFKD
INDNYGHATGDIVLTTIADRIRALLRESDLVARLGGDEFAILLAPIYNTDDVLTIADNII
DSMAQPIILSNGSEIITSLSIGIAIYPDHAQTPDELLRRADEAMYQAKKGFQPCGRGTVQ
HAGFTHTEKTG
>A0A645I8S9|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MEAAAYEDYLTGLLNRRGLSNALTRLDFSQENIAIFIFDMDNLKCCNDSMGHTGGDELLR
RFSDILRSHTRGGDIIARIGGDEFVAVIPQMRSSESALKKGQEICRAFRDSRPGTPDGCV
ASCSAGLAILKDRESFDDAFARADRALYHAKRTRKGACFD
>A0A644ZBQ3|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MMLIMIAVAFVLSLAPLSFPSPNRPAYLLLLGALLILLISAMIAQYKNRYLLSAYLTVAL
ALAGTWPSILINLKAGVPDFFPLCYVIITIMLSSLFLPSLVTIALAAIQFILLVVLVASS
ATLQLQNWPSFFFFVLLVSLLSMIANYLIKTQMRQLNESAIRDHLTGLFNRRYFDETLSN
KLKREQKEGEPWGIILLDIDHFKGFNDQNGHDAGDFVLAKLAEKLLSYFNLSSTICRYGG
DEFAILVPHLEQKKLDELCQGLVEQVHSLTLLYAGKNLGSMAISIGYVRYNGQLSSAELF
IKQADSYLYQAKQEGRNRAVGSS
>A0A644YNB8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MHLLYFDLDHFKLVNDRYGHRAGDLLLAEVGKIAQQPGCVAGRMGGEEFALFSSVHPRQK
MEQISEQLRISVESLVLTLDDSEIRATISAGLASLTNPTFDQIYQLADSLLYQAKRDGRN
CVRF
>A0A241V3H5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4204|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHIKAQNFIQQHSFVLVNEFYRNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVALNQAYFTAVEKQQKVGQVHARVGIPSWLIMRGIREIEIK
ILQLLDELQLKNSHQMLSYMLQIMGFATEIMCRSYEANTEQSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIG
LIQQVDALNLHVLDCQDQTQKIERIQDIREMNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARRNDAPLSLLAIDADYFKGINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSNLQRASDVAETIRSRIQETSIRTPLGQSFSFTVSIGCTI
YNGHPDYQRFLDTADAALYTAKNNGRNCIHVSEKLLSV
>D8PAA9|diguanylate cyclase|EC 2.7.7.65|Nitrospira defluvii|TrEMBL
MIKLLLVEDNPVDAQLTRDLLAEWPLDQFEITHAPILAEGLTRLSRDRFDVVLLDLSLPD
THGLSTVTQVLATSPGVPVVVLSGHDDHPLALKALQHGAQDYLVKGEGGTEFLARSILYA
IERKRAQERLTYLAQHDQLTGLINRALFRDRLIHAMARSKRKDHPLAIMLLDLDRFKAVN
DTLGHDVGDQLLKVVATRLLECVREVDTVARMGGDEFTAILEGISGVADVLVVAKRIVES
ISTPFEIGPHRISIGVSIGITLYPLDDEDIDELLRHADKAMYAAKQQGGSRFHFHSTTGQ
PPSGTPAPVR
>A0A087BQI8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium minimum|TrEMBL
MLNASAQGNVPRTILVVEDEPDLATAIAQRISAKGWTARVASDGASAVRAASQLKPDLVI
MDIMLPVMDGIEATKRIVAERPVPVLMLTARDAEADKVLGLGAGADDYMTKPFSPRELIA
RCEALFRRVERAATIAKNMENEKVLDFGSLVIDPRQRIVTRNGEEIHLTPTEFDLLATLA
RHPRAVLKREKLLEEVWDWPDASGTRTVDSHVKALRHKLGSDSIRTAHGVGYAFEPPEDG
DAPARTD
>A0A399H1Z8|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. YIM 130001|TrEMBL
METESEPYVRLATLRQLHQAVAELNTARSLADTLQTVADGMVSGLGYGLACVNLVRPDGD
LVIAAFAGDPAAEALITGRVGSRSSWDRRLAMGEAWGDLRFIPHTEGWVLDEDDVPQWHT
DGPAPRFEDEWHPADRLFAPMYSPTAGRELLGVISVDRPRNGRLPGAWAREALQMYAFQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRILR
SNDALCRLLGRNASAMRRYSFSDLVHPEDVGTLLRTSAEGGRAELRLVRRDGTYLWVSLR
NSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRSRLAARLCSM
PLSVQPTAIDALDAAYGAPSAYDPVQDSGGHTFRFDTPPPPLGAYDHHVHVIGPEGETDD
GTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLTGGVRDGDTVARLGGDEFVVLA
DGLGRADAADLAVRLRSAIIPPIRVDGRAVRVGASFGIGWAHCGMTADEVLQSADQRMYI
EKRSRAKQHRRAG
>A0A6S7DFU2|diguanylate cyclase|EC 2.7.7.65|Achromobacter pulmonis|TrEMBL
MDPILAELSTSLQAARSVEQLTRPLLDMLGAVTGLESTYLTSIDPHGQLQHVRYARNTGA
LQIPEGLSVPWPDTLCKRALDEGRMTTSDVSACWPDADAARKLGIRTYVSAPIRTDDGQL
LGTLCGASASRQPVAPQTESILRLFCNVIASFLERELLVAQLRDANAKLLAFALTDPLTG
LPNRRALYEELERLRGRALRDGGSVLVGVVDLDGFKGINDTHGHQQGDVFLQEVGRRLAM
AVRASDMVGRLGGDEFVLIGPGPALARGDAAPGHEAERGDAEEAARSLEDRVAAATAGRY
PLGDGLLPYEGASVGVVALDPRGLSAQEAVRQADARMYEVKHARKAARTIH
>A0A1S7RH79|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. Kerr 14|TrEMBL
MPPRTLSAFIRIYLKKNARMSETIDTNIFNLAPVAMWIEDFSDVKSQFDIWRSQGVEDIR
TFLLEDLSRVAACSQKIRVIKVNVRTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSE
LWAGKTEFTSNAVNYSIGGKRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKERL
NRRYAEGMFKHSPVSLWVEDFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVI
DVNRATLDLFCAPDRQVLLQRLGDIFRGEMEKPFREQLMELWNGNLNHHREVVNYALDGS
ERHVLLHFSVFPGHEHDWSLVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEL
NRLERSALRPVSAIVIDLNGLKDANDKLGHDAGDALLRRMGEVLNGVVTAPNHAARIGGD
EFAILLPGADKQVAAAMVETVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRAD
MNMYEQKNAYYAALRNRSADNSDTTKNGPPEATSLKRLF
>A0A0H6R9N0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVNRADSARLLSDQDLQGYVSRILDVIPLPIIISKSSVLGQGEREHLHFNKAFVKELGYT
MAQIPNIETWFERAYPQIDYRQEIIAQWQKTVDEARAQGEDVAHMPALIMCADGVQRWFS
VSAQIEPSCRDDLHIITFRNIHDYKISLAEAERQSQIDPLTQLKNRRGFFTWSEPIAPET
LLGLIIFDIDHFKQINDTYGHPAGDYVLRQIAGLLEQNLPPLSCCVRWGGEEFLVCFECD
DMANVIGLAENIRDYVESHTLMWQGQQIALTLSAGCTMGAMMSHNWDNLLHTADQALLSA
KRLGRNRVIADR
>A0A656A3M1|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNTHCRELDLLFRLGGDEFLLLFENTSLTDATLVMSHIGCRIQQTHYPYHAKVTVSVGLA
EALRTDDPEQWFKRADQALYHSKKMGKNRVSFDEEHVIELNGDHCHALLGSTHGHR
>A0A5I6RWE9|diguanylate cyclase|EC 2.7.7.65|Salmonella potsdam|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTQGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEECGDYDFEQLQ
SQADKRLYYAKQSGRNRICASDATQEREKK
>A0A109LCK7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQPSLRPRRPATLAELRQQLNQQLQTSLEPERILGLFF
REVQRLVPLDALQYRHAASDLRLEFGHRGHHSVSYTLSHEGEHLGELVFRRNQRLLEEEL
SQLELLLVTLLYPMRNALLYRAATRSALRDPLTETGNRVAMDQTLQREIDMARRHLHPLS
LLMLDIDHFKKINDTHGHAAGDSVLRAVAGAIKRQLRNVDMVFRFGGEEFLILLSNTGRD
AARMVGERLRQAAQAQDYWVEGTRIELTVSLGCSTLLAAESAESLLRRADNALYVAKREG
RNRLAMAG
>A0A109LCP9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDDTSGKEPLRHEVSDLNVDLLHAIMELVSDGIWDWNANTGFVYRNPGWYEMLGYSHHSL
ENSVFTWENVIHPEDYPRVMTVFDDYISLRAAHYRAEYRCRKKDGTYLWIEDRGYVIARN
PDGSVARMVGAHRDIHTRKCSIEQLQKRNQSLEALVAERTLELSRVNQQLQLQLDENRSL
AERDALTRIANRYRLEKVLLEECDRAERFRLPLALVAMDVDDFKPINDLYGHGVGDQTLI
RVVEHLEACVRKSDLLARWGGDEFMVVLPKSSLDEAKELAERIRHKIKEAAPVGALNVTL
SLGVVERRMGESPAALMARADQALYRSKAAGKDGVSE
>A0A3U8IPE4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0W0U6X0|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MVKQKEEKSLLLLEGSLRAIPFNIVLSSLLAAILLYHDTPVALVGFWLFSIVLVSLIRWF
FCFYVIRKGLLHKSSLLITFVSLTLLMGTVWGASYWLTLPYLSQPNEFIVILVLGGMSAG
SIASLSAYLPAYYAYIIPMFLPVIAYNFYIMNPDRAILALMFLLFIIMLIISAILNHRLL
NQSLLLSNEKEKLIDKLHLLSITDPLTGAYNRRHFQSILEQELSKKRTNQSLLTLILVDV
DNFKEINDKFGHPHGDRVLIETVQQLKKAFRREHDRLFRLGGDEFCIVLNNQSVQEIISL
CQELVKIYPSNHMDGSFITLSIGILPIPVDSKANYDRIISSVDNALYKAKQSGKAKIVTF
QSIN
>A0A4Q8PJ62|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Brancaster|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A150CIJ0|diguanylate cyclase|EC 2.7.7.65|Bacillus cereus|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCKHQQTVENIHPKCMFIANSFEEGELLFQR
TKPHIIITYVTDYSQIKYIKNMYTPHSTFIVIWDQQITKEFTDVLALGIRNIVIAPVTPQ
AVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFQNDLLFIVEDDEIVDCNTNFLAFFGYEN
LFAYREQHLVFAEHFIRENGYYSTTHDITWLDDTLSSGRRIKMLNYEGAVSTFLLRATPL
PEDLSRFIVKCTEITELDETYQEQERLAMIDSLTEIYNRLKFQQILEVEWEKVIRSDEKI
AIILFDIDNFKTVNDTYGHDFGDLALIQLAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFTGISKLTASFGVALYEQGTTREELMQRADIALYEAKKNGKN
QVCVYRKEKM
>A0A2T8MLF7|diguanylate cyclase|EC 2.7.7.65|Salmonella anatum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G5NME1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLREDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A1N6LZ14|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MIIKVVFSQCLALPWEDVIIKIYKFNPWIFCLLTIGYVLLSFMAVNLVTERFVNKQSQEI
KEIIQHELALVRYSIEANVFRDTYLADSFASVVALNPQFAMKNWEYVAKQFLSKAALVRN
IGLAPNNIISHVYPLKGNEEALGLNFRTLPQQYKTIQIARETQKVFIAGPLELVQGGTAL
IARYPIFTDVPHNANYWGGLSVVINYDKLIALSNLHQFKDVDVALVANNYNGTTSKLIEG
DDAILKDFDISYPIYLPNVNWTLFAKYKNFHEIESVSQFENLFYTLGFMTFSVVYFLILF
LINNYLRVHELSLHDELTKLPNRRYLFNEFERIKLRSGTLIELTVLNIDLNRFKQINDTL
GHEAGDEVLKYIASSLTKCLRSSDFISRIGGDEFVVILQRTTKPEYIEQIIHKIHIYFES
NPLRWRNHEIEISLSIGHYHFQGPSGDLVINDILSEADKSMYHDKLSQRKNEKVSENGQ
>A0A5W2LRN0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lattenkamp|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDIGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A174LNK2|diguanylate cyclase|EC 2.7.7.65|Enterocloster clostridioformis|TrEMBL
MKRKLIGTWHAAAFLTFCFVLALTASGVFYNQRGKLAGEFGNMVAANLTSYTQAQKRYLN
SSITDAWNTLKGISGLVEQIVPEYTEDSLNEYLDQLNLQNRDYMIEYLSLKELERRLRNQ
QAAERDWTLFRKIEQGTGVVSDIWDWKKAGNQSVFTVAEPVWKNGKVIGVLQTRLEPLTI
TEQVPEASAFTRSSTLIVRRDGTILASENHNRGDISTGNLFVSVKTSGITDEVVRQMEEC
FYGDGSDSFMFEGKGDSYYFSWDYLGYNEWYIVNFVRSPDVAIHYENILKELIYASLFLI
GLTAVLGGGIVVLFLHYRRSLDFETKKYGLLAEFSDTALFEYDRRKDILEFTNNARRILM
LDELRISHVMGKKIRTDLFLQEDRKVMEDMLRSRTGSWEDNIQYAELRLKSISGEYHWFG
CHYKTITSDTGTVVKVVGKLADISRQRSREQELREQAMRDVLTGIYNKAGERLIDRMVKE
KGQGLFLMLDLNDFKSINDTMGHAAGDAILTELGRVLKGNCRENDIVARIGGDEFVMFLP
GVFDRQTGKRKIGEIQESLRTVRISTWGIRGIKASIGAALCPEDGMDYGTLYKAADEAMY
QAKEQSKNRNESGEAGEENHDRTIS
>Q1PXY5|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MSIRIKLILFISGIIIIIDALSCMSFFFYSKKRYRVELRYFGETLVNLFSRDNEIRYALE
YEQPLLFASPVRRIKEFDRENVVCYISISNDREKLFEDKATWLDIETNEIPGRNHQDDTS
DTDYRVITVSGKRFYEYFTPIRERQVFSGEGLAEQILSEESVNRKNMPKGFVQVLLSTHR
LDEKIRSVIIYSIMPVGIGIVFGGLGIMLLLTKYIVSPLQHLTNVTLEIAGGNLDRKVHA
SHNDEIGQLCDNFNQMTDALRNSHNHLTAEIADHKRAKEQLLKLSQAVEQSFTAIVITDV
ACAIEHVNPKFTEVTGYAREEALGNKLFDLLLFNMSDERHENIITMVLSGEIWRKELVNS
RKDGEQFFAQVTISAVRGDDGYIINFIGVIEDITERKKFEEMLVVMAEHDPLTNLFNRRR
FQVELEYWLGYSKRYNTGGALLFLDIDNFKYINDTLGHKVGDEILVEFAILLKERVRPND
IIARLGGDEFAVILPNTNVDHARSFAEQITQSAQKHFRVLNERGHNITTSLGIALFPDHS
LEADALLACADMAMYGAKEAGKNQCCIFSLEQKQNIESRFLWDKRIRSALGKDDFEIYLQ
PIVDLRSNAVFGYEALLRMVGENGELIPPAEFLPYAERHGSILDIDRWVVRNAFRLFVRY
NMQEKKAVLEINLSGKAITDSGMLSFIKEELSASQADARYITFEVTESAVVENIEYARYF
MNDLCNQGFRFALDDFGIGFCSFTYLKHLPVDFLKIDGGFIRNLPDNPTDQCFVKAIADI
GNGLEKKIIAEFVENKQTISLLKEIGVVYGQGHFFSKALSASEIFKTSS
>A0A174G2F4|diguanylate cyclase|EC 2.7.7.65|Enterocloster clostridioformis|TrEMBL
MTDEILETKALKVERDRDGLTGVGNRLAYEHMLRHKNSHTEEIPGSGFLMCDLNDLKGVN
DRFGHDRGDEYIRRSADIIREAFPGAPLFRIGGDEFVVQLDGLGQDQVFRGILAMERAVK
AYSDGNVFPAGIAAGYAFFDPGKDVSLESTLARADT
>A0A3V3TWR6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Havana|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6C7HND0|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis PT4 (strain P125109)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A098BPP5|diguanylate cyclase|EC 2.7.7.65|Rhodococcus ruber|TrEMBL
MGDRQVLHGATANLRVQRRRLLAWYLAISTGLVAVGIVAALLDPAVARSGSFAGMASALA
LGIAGLVILRWTPRRLGRTPIVAATACAVAAMPAVIAFHVDPSRILISVMGSMFLSMYLA
AFWPPRQAVLWIGTLTAATLGAAALAPTRLLWVGYVVVAAALLGSGAIFGAVGRLLVNAA
TRDPLTGLRNRAGLDLELRSRPRDRGAWVCLGLLDVDGFKAFNDEHGHPAGDALLRDAAE
AWAQQVPRGGILARLGGDEFLVVLPDTDEEEGRAVLEGLARANPVPVSFGVAAGVVSDPM
DLYHDADMDLYRAKAAAWAQLPDRLAPLPLPDVLDLLPVPILAVRDGGTVAYVNPCFATL
FGVDARNVENRPLHEVLTGGTWPDRSVTVRSLHDRTGQLCEFGRPDGTVVQATVGAARIR
WENTLATLVVLGDVTEQPSYVSR
>A0A2K1G2B6|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTNSSDTRSPSDSLGLVLDEHLRWIGQWHRAVFFRGGQGGERVSAPASFAAWCVAVNADD
LAHQPAVEKLVTLHEQMHRKAKLLLLKAAGGESPSEADYEGVIARFEEFVLHLRRVERAF
GAAASGLDPLTGLRTRRGMQEALEREHNRFRRNGPAFCVAICDIDRFKGINDTYGHDIGD
RVLAATAAAISRGIRSFDEAFRMGGEEFLICLKETGLAEGFRVIERLRGELARTPVTLPD
GRRIAVTASFGLVEAGEDLPVEEMVVCADRALYQAKNSGRNRVVRYGVDQPEVVAGRSAL
PNRR
>A0A533QM09|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MKYRHSAAQSTDYLRLALKHMTQHDAGMHPTSYTVWYEYVSGANPALRRELDSLLQGGGR
LNDQKIDDLHARHISELDARTALRIGDSVSQLVGHVSESTAAAGDEAARFGNTLARWNEE
LIAPATGSGALASGVEDILRGTRQMQEAISTLRTRLAESLSETERLRQEVARAREEALID
TLTGLTNRKGFDLALAACLAEESAQSIGPCLLMIDLDHFKKINDSLGHVFGDRVLTTVGQ
ILRANVKGKDTAARYGGEEFAVVLPNTPRGGAVGLAEALRALVAASRVRRSGDRELVVGN
ISVSIGVADRIAGESATDLVNRADRALYAAKMQGRNRVVLAPRPEAKAGQ
>A0A0T7RRF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3R0LML1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A0A6U5L7|diguanylate cyclase|EC 2.7.7.65|Xanthomonas campestris pv. phaseoli|TrEMBL
MSPGTLHRNSESAVLPQRVLLVENSRTFTSMLREAIEQRVELPVTVVSTLAEAARVLDEE
DGWFLVLTGLVLVDGDRDKVVEFFLSRKLPTVVVSGVYDEDLRQRVLQQQIIDYVLKNAP
GSIEYLAWLVQRLERNRRIAALVVDDSLSARTYAGALLSMYGYRVVLAADGAAGLDAIER
DPGIRLTIVDQEMPGMDGVEFTRRLRAIRSRDKVAVIGISGNSDSSLIPRFLKNGANDFL
RKPFSREEFFCRVSQNVDQLELIGTLQDLATRDFLTGLPNRRYFLEQSQRVIPKLLLEDQ
TVTAAMVDIDHFKHINDTWGHEAGDQALRAVAASVSGHARPQDLVARFGGEEFCLLVPGL
DAANATSYFETLRERISALRVRVGDETLSMTVSIGVCIASESDQSLHYLLNEADKHLYLA
KAGGRNQVRLAS
>A0A380ASL4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A0A6TXW0|diguanylate cyclase|EC 2.7.7.65|Xanthomonas campestris pv. phaseoli|TrEMBL
MSMFVVRWRHGLAAFALLLGSGMASAQPQPWKTIEAATIDDPVTALQIAQGALQRASRDH
DVDAEFWALLAQARVLISLEDSERRQAVLTQARGKLDQLHGSTPQAWLWLDIVQALSDVR
ENPNRVMVARLEALRQRASALGRNDLLCEVEAVDMWSMLASGSSDESWSAAQASYQCAAR
ENLLGLELDALTQLGALASRVGGRAAEDNETEDYLQRALARLHDQPARFQRSLVEFEFGT
ALATRQPEAALLHFRRALALSRELRDQAGVAAALTSASEALIETGDAASALTMAREALPL
MQQQGNIGRVAACHAVLLQALIALKAQGLDAEIVAAKAADDPNLTLNRRAQLVDAIAQAL
AFQGRHAEAYQELQRANALRAQSLDRQRDTVMLRLQARYEDARRGAETAELRRRSETAQL
ALQAREAGQRTLWIALCAACLLLLGALVVLAFGARHRRQLSRLAMRDELTGLPNRRAIRT
EAQQQIEQALRSHTPGMLALIDLDHFKQINDVYGHATGDAVLKALANASRLALRGQDRLG
RLGGEEFLLVLPGCGEEEISTVFTRLRSAVAAIDIAGLPPDQPVRFCMGAVRIVADTGLD
ALLSQADLALYAAKTAGRDQWAVC
>A0A0D6INV8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRYPHIPWLPLLFYPALPVIAAAGLLLWRDWPPALTLVVPFVPWVMALIGAAICLMYQRS
QTLALMLAVLAPAAAWPTLASQAPWALAPALVWWSLAYTINALWPERAGMLRDLAARVGL
MALGAAAIALAGKEGMAQLFGALAVQGALARLGLPFEALAALLLTGLTLTLLLLRYGRPQ
QAGQWLGFVCMAWALPRGAQHEIELAVMAAAALTSLSISLAHEGYHMAFRDELTGLPGRR
ALNERLQRMGRVYTLAMADVDHFKAFNDTHGHDVGDQVLRMVAAQLRRVPGGGYAYRYGG
EEFTLVFPGKTAVEAMPHLETVRRAIEAYQMRLRDKPARPKADQIGLRRRGARGGRNARP
LRVTVSIGVAERGETLRAPDAVIKAADQALYKAKDGGRNQVCAYGSRRRAGG
>A0A5H6FGZ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Alachua|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A202B5N7|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MTTQNPIEVARETLKQLSTRKLLPTPENFERVYHELTQTPMGRDNKLAVLLLRALETLPQ
DNVQAKVTMTRLRQVLDENRWEQAPQLIIDFLRGIFSAQQLAQSWGQLIQNLIKSWDLRQ
PDLPQHHKQSTLERVLINFGNQPEELNQKLVALLQNWNASPSSRDLPPPEPLPALDGADE
AASDASGSWQAWQRTLAFALKHGLEPRLSDYPDLVDGLESLLQELEGIADDPSLNVFMPK
LRAFMIKLELQSQQEGRLATGLANLLKLMLDNVAELNRSDEYLLGQVGSLQEILSHEPLS
MQQIYQLETSLKEVIRKQGMLKSSLDEAASSLRALLDRFVSRLALMTDSTDEFHGKIQAH
SEKLKQMPNVDELGGIIGSLMEDTSIMQLDLTRSRDELVSAKEQVEAAEHRIRELETALE
AASAKVKEDQLTGAYNRRGLAEYFQREIGRAERTAAPLSIALIDVDNFKQLNDRYGHLAG
DDALKYLVDTIKHSLRPADIVARFGGEEFVILMPDTPETEAVQTVQRLQRELTKTFFLAN
NDKLLITFSAGVARWHLGEQESDVLERADHAMYQAKINGKNRVCSAEDMPG
>A0A730JIJ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A484VDT5|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSASTELLATTWRRAQARHEPRTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIALNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLADAPAAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENAFVYEVAVNGAAPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCATIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQTASHLSVLSIDIDHFKGINDQHGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQATAIGEKLRRRAEHERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADAALYGAKRAGRNRVLAHSAL
>A0A447KKT8|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MNARIISKYGLPVALQLINLFLLTFLLSLVGIFSRPIGSLSLFWPVNAILLGLLLRKPAY
ATPMGWLATYLGMVSADLTTGEGAPLALWLNACNMALIATGYGVMLLLPQSQRRMGKPQA
ILYMFAASLSGAAVASTLSVLRNDSLYNNTVITAWLAWFSEQFSTTLLILPVLLAAPRLK
PLLRMRFNWRLSASLPLLALIASLLFSVYIGGPGAIAFPIPALLWCAVSYQLFTVTLLTL
LTGIIEISSISANVMLYETPSTRGALLDTLMSARLGIAMLVMGPLIVSSSIAVNRKLMRR
LEHSASHDFLTGTLTRSALMRKTRELLEQKQRCKEAVSLLLIDVDHFKLINDSYGHVIGD
RVLANFIHLLRRELRPDQLLGRLGGEEFAIVMPRALAAQAVAMGEYLRRQVEKAQIDTGD
RAPLKLTISVGVASLAMNEDKSLEQLMNMADIALYRAKSLGRNRVEPFNVLSGNSVDHIL
FK
>A0A398PVZ6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHNPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A094RY29|diguanylate cyclase|EC 2.7.7.65|Pectobacterium odoriferum|TrEMBL
MNEQLNVNEQRDNGESDYNQVITSEWTKLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAKVAEDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSDFGLWFNHKGK
SSFSNVQGIRTIATIMTETDEYIRSYSNTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTSLSIAMIDIDHFKSVNDTYGHAA
GDNILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIHL
QNGGSVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A078BGQ1|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. CB2|TrEMBL
MCSVSTRSVIRWLFWSVGLAACYILVAWLVLGVRSSELILWPSAAVAAFGLIARGPSMVP
AIALASWVSDYMLLGWGLQASALIAAGDVLGPLLGLWLLRRRARWQGFETTADGLWFIGA
MGVIGAGVSAAVGAAAAATFGFGQTPVSPDLGVQWWVTDMASIVVLTPAAELLRRASLQT
LRAAFNGEMVWLPALAVIGTLLVYLMPVGQSALPIGLASLVMLPLLWSAMRLPLAVSAAL
SAVISLLIVTATVLQHGPMYSMLGSDRFMSMQIILLAFASAMLLAGLLANERTAAIKQVR
DINATLEKKVNRRTAALQISQATTQAQLRFQESLLNALPNPVAFSDPQGRFTRVNVAFNL
LVGLSGPEIHGRTGTQILGTTLGRIWEDMDSELLSGSLQVTREAPYLHPDHEPTVWILNK
ALVRDAVSRQIVGVVTSMQDITAIKQLQQQLSEDEQRFRFLAEESPVPLVITRTSDAALL
FSNKVADSLFRGSYAEHAGQSMRPLWGDSVDRDQLLARLQREGGIVRGVEAQFRRFDGTE
VWLLLSVTRGRYRDDDALIFAFKDITEAKARESELRNLAYTDTLTGIPNRRYFLARAALE
LRRAQREGSPFVVLALDIDRFKQINDRFGHQVGDAVIRCFAQTCMQQLRGPDLCGRLGGD
EFAILLPQTTRQVAFDVAQRLRLSIQEASCLPSSAPDGLTLTTSIGIAEFLPTSTLMDAD
ELLDRADQALYRAKQAGRNRVEIWTGEAPAPV
>A0A0J0HE94|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASSADTLERQAVEQRQKFDQLTEDIETDIWAQS
DLARLYAIKKDPQVLKEYNQAENSLKRIELRLEKLQDNGASDEELALLHEGIKIVDELQD
EQQTALESLERGEDAQAVALLYGQPYEQELERAQNQLDHFRQILDKRVIAAVQEATKKSK
ALRTASELTVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAISIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYVLDREPWQMRCVAQWLSPVGEETTFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPASQAESALCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQTAQAIRTGVPLSCMMIDIDHFKSINDRFGHEA
GDLVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLSGADEAEAYACAQKIYTGVHELSLRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A3G3E3L0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A377PHX9|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MKLKNLIYIFTTALVFFFGIFIYSSLHKAHVDFAQNQQNLYKVKRLRDLTEVFQSALLVH
RLKRISFMSDAITQSEILDAEKQVRLHADALVLPPSDKSATELEKQTHEMFNRAKFFVYR
LTANDNQELSAAGHLMQAQLDLKSSYYITELNKLYFLYVYNTTLSDTHSYKFIESVRLNN
RLTLTATELIDQLVDIKTDEVKRNQSYLRSIELIGVLDSLRSRVDFIIATAPDEAQPSAN
IDELLSKLSKESMQHLTADLTSVMQSRSSNAFDGFYRYIIGIDKASAIFVNNSYDLELHE
LEKKISVSRVQLYGMISLCWLLALFIVMPILVFSSKISLWLTLTNKNIMKLSQGDLDISP
DNSIMTGELSAISDAINQLRQNQIEKRLLETEKQELINELLEASSTDPLTNIYNRRKFFN
QCSQITEDDYPLAFCLIDIDNFKRLNDRYGHDVGDLALIAFSQMLEQSLPKSTVYCRYGG
EEFAILIKYENMQQSMRIIDVVRHRTEMLSIAIPNKPSVGFTISCGLARLDDYQNINHSI
KQADEALYYSKKRGKNQVSFYSPNGFISFDANDKNG
>A0A3V7KI23|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pomona|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V0R4V0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1U7FN51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7W0E253|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SIWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILVVCTYLSMTGIISYAPLF
NFTAMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIAQCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A315GM88|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:i:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1J7Z3P6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MKIVQDKLRNRQALLVSGLITLIFTSLFLFIIYEQRMAAASEGVSRLQAHMLDIFNDNEL
IADAIGERYYHIKTGEQCGVMAQFVPRNKDEWGINADPKRVHSATGTIIAQQPSHNALCM
YTAAEFIRGMVNELNPGSFDAHRYIIASNSDYFYWFMASDSRNFSFSDSEMAMDITHFFY
PPTDFYTRLLQKNVKNKALSSTNFYTDKITGEKAYSVVSYIYDLSGKEISDQIVAYLVYD
HSKPELQEALAEAFDNQILPGLNVELVNLTNKESLCLSGKCAGQSSYLVRNFSEKYALHY
SLSLGRFMARDTHAGIVILLAPFFFIIISFSLKSWLNESDLKVYIDTLTGCFNRRILDII
KRRDLSHCSVVLLDCNKFKAVNDTWGHAAGDRALQIIANRMLSNTRTSHDIVIRTGGDEF
MILLFRSQATDAIAIAQRISGQVTSHVFVVDGHTVPLSVSWGIAEVNGELDVAIQNADSA
MYRMKHTEEG
>A0A431SBY4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVTPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRLL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTTP
>A0A403STA9|diguanylate cyclase|EC 2.7.7.65|Salmonella thompson|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4S7X5R3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELAQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A431SLK3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQL
LSGVWWLLLVGWVFVWPHLAWQLAFRSTCPHGGEIVNLKIDAIIAGVWMGLIGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PMLFAWLSHHTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRHATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRAGDYIGRFGGDEFAVIMSGTPADN
AIAAMARVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A378F652|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQLRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A486W3C1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A403MHC9|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCVVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASLGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377YKI0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWSCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A8B3VAJ1|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MKAPQIPVNEAQRMNALRESGLLEIDNYPAFDRLTRLATRFFRVPLAMITLVDDHAAIVK
SADGRALASQPRDLSFCGHTILGDAPLVVSDTLLDERFADNPQVAGDPGVRFYAGFPLRL
RDGACVGSLCLIDYAPREFTAADAAVLADLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
FAQFALSVSQRRAEPLTLGWLDLDHFKTINDRFGHQEGDKALKAMAALMRSSFREADLLV
RFGGDEFAVLFADTDEPGAWIAMQYLVEQTEKYNARQLHPWSLQFSWGLSEFDHHRNDIQ
AWLKHADAQMYAMKRQHHGEK
>A0A083ZR30|diguanylate cyclase|EC 2.7.7.65|Rhizobium radiobacter|TrEMBL
MGQAISRPDREVERLVAVRSVVAFKNAETDELRAISQLAQGVFDVARAAVHILDEDWLHI
AEQAGLQFQECSRDIAICDRVVVTQNVLTVSDLSVHPEFGWLPYVKGSPELRSYAGAPIE
LEPGLVVGTFCLLDPNVREYSPAEIDNLRYFATLAGALLRLQKANFTMSLAARELRDAAM
TDPLTGFYNRKALDAIVDLELGAALCERETFGVLYLDLDGFKAINDTLGHAAGDKVLVEA
AARIRDVVRAEDTVVRMGGDEFAIFVPRPMSASVIGSLAERLLEAFRQPFHVEGEDVLAR
LSIGGAIAPQAGADRPTLLRSVDEALYQAKKSGRDRFVSRAL
>A0A3T9Y9R6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5M9GZX0|diguanylate cyclase|EC 2.7.7.65|Bacillus paranthracis|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEEFSFWQKCVVGIFTGILSVLLMYFGVHIEN
IMLDLRYLAVILAIIIGGPIASSITVTIILITRLFLTEYSLASELACYTIVLIGVGIIFI
WRMKASIFIRWIWFNVYSLSILIVPLSMLFKDMSIVALYLVCSSVAAYITFISANYVLQS
NELFQKMKQYATIDALTGLGNVRQFDLEMNHHIGNKRMKNDSLCLLLIDIDHFKSTYGHP
AGDEVLKQIGRILREVSTFPDLAFRKGGEEFALLIPQKGLAYGMRMGEQVRAAVEKHSFQ
LLDGTKIKITVSVGISVYEQSPEQFIQAADDALYYSKRNGRNQVSSAS
>A0A0P7MG42|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H1W715|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMTY
SLEAAVVFADGPAATETLAALGQQGKFSTAEVRDKQQNILASWHYTRKDPGDTFSNFISH
WLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLH
NGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATG
DRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLH
NGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A853T0C9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MDIKTLVLALALGNLSLCAALFFFEYERKKSLSMSTWAVAKQCQAIAWCLLYFRGVLPDF
LSILLGNSLLFAGMALDAGALWQAAGRGGWRRYVLPALGLSVALFAACYLFDVAPLLRSA
GGSLIVAGFFLAGVAALCLKWREASMLRRFLVVSMGVLSLLIAARGVLAATVPGFDAELM
QLAGFGALYLMMLTNAFGYLLLSREKLGGELARLEVLDAATGVPNRRGFYQALAPWMALA
RRPGLPTALVVLNIDHFKRVNDSYGHPVGDAVLKTIVDTCRQQLRDSDLMGRLGGAEFAI
QLPRTTLADALMVAERIRAAVEALPVKTERAVLQLTASLGVTTIRAEDSTVSLFKRADEA
LQAAKQAGRNRVVEAQGASTLDI
>A0A7D7DZ79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHETKMENQSWLKKLARRLGPGHIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLAVNGVSDALVREGNQLSRENESLNNEITAALEVGYLLRLAHNSSSMVDQAMYVSRA
GFYVSTQPTLFTRYVPARYYEFVTQPWFIGQSERENRQRAVRWFTSVHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGLRMNSRYVSWARLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWVLFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLIGRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIARSTTVRISASLGVSSSEETGDYDFEQLQ
SLADRRLYIAKQAGRNRVCASDSP
>A0A828NN42|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSNEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A718QQ95|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain SL1344)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A166VT68|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2X1MGY1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A377CJX7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLAQHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8G9X4V6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGKINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>J7QFF9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMTVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376HKS5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGEAIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A0D6I695|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A826VDV8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVTQASPLIRAKAAEIAVAHAHYLSNEFYRIVRTDPHAEEFLSNEQ
VERQLKSALETWIIDVLSAQADDVDRLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PAIFSSDYSPADKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWELDVIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFNQTILHAKNLSNKSLRVKFLLQIRNTVSQITTLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASETDTLRTAERIRSRVEKTKLKAANGEDIYLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0K4IW44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAH
PGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A4Y9BS30|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2B7LN27|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MTTHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQELTFSQLRTGLYSISSQNELPK
YLTDLHNQLDIVEILTVQRNGEEAALSCRLTLKEMSETGKVIIFEGMETPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRIMPVMHEISRLPGGHKPLNFVHKLADGSIRHVQTYAGPIEIYGDRLMLCIVHDIT
EQKRLEEQLEHAAHHDALTGLLNRRQFYHITDPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHQKGDEVLCSLAHTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRLSVA
KVSISGLPRFTVSIGVAHHEGNENIDELFKRVDDALYRAKNDGRNRVLAA
>A0A718V2Q3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain SL1344)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0K4LST3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLSPTEEQLLMGLRTAYADSISPSYLYDVGPYLISSDECIQIKEYEKNYCSNIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVNHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGQPVVGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDIYFQVCALIIFFAALVA
IISGTSCLYLVRRVINRGIVEKEAIINNHFDRVLDGGFFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKTLPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLIKVVRILKAQIPL
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGIAHTNECTSVERL
KMLADERLYKSKKNGRAQISWQ
>A0A221ZN00|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEA
IINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLC
LFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEE
LLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERLKMLADERLYKSKKNGRAQISWQ
>A0A376K7T0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINEQKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2I5SNH2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFRSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0L6XRZ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQGAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3V7IE89|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weltevreden|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X5T3G6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPFNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A3T3ZPV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0Q3KEH1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSLLQWQAWHDTLTRLYNSGALFEKARSLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A765T301|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAATHGGEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKADAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A8G2AII0|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNKDFSQTSRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQPFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIGLLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A2A5MEI5|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MLTNFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITTALLILNALI
WPSVAYLASMMSKDMLSTEKKNMILDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALMWMMISFLTVWLVNDFRYTIEFSTRTVLLSLPLATCYPIVLSIVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSKLVIAMVHIIQKKIKDL
SLPSHNDIYCTVSIGISCAENKESIIEWIKEADEMLYEVKRNGKNGYCMPNN
>A0A0H2WRZ9|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A (strain ATCC 9150 / SARB42)|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A427MC67|diguanylate cyclase|EC 2.7.7.65|Rhizobium pisi|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYEALAICERHQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDNLTRAGEGRADENAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGSD
EMVVRALDLGVNDYIVRPVDPNELVARSLTQIRRKRYNDRLRNSVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEVAATVAERLRAAVESTSFALKHSGQALSVTASFGI
ASRIASVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A5I5U0Z3|diguanylate cyclase|EC 2.7.7.65|Salmonella abony|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3P6LKN7|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A7Z8Z7X0|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKDYPKGPRPTFKRALRRISMISVIISMTLVWLLLSTASVFTLKQYAQKNLELTAATMS
RSLEAALVFGDSAAAEDTLATLGKQGQFSKALVLDSQKKHFALWHNHDLVSEEKLSGLIS
KWLFPQPTVQPIWHEGKMIGELRLTALDRLISHFLGISIIVLTGSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVISKLMNDDVTHRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMAFAGTDHQAWRLGGDEFAILLRNVHTEAEVQAQCALLSAQFLQPFNL
HNGHTATLSLSIGYALAWEHTSAENLQEFADQNMYRMKHQRLQQVQK
>A0A3Y9LUS0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A0W3K4L0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X2GH23|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MLLKELMIFDLLSTPVWVVHPFKEVVVYSNQASRTLSGAMSLDEMRKGTLSSCPQRSLQN
YLYYFKNIAEVFEVWTIQTPEGLSPIYCKTTLIKSEEYDTLILFEAVKILQQNDSFKALP
AHTYKRRSNSFFSRFFMTSSAPMLLIDPEQDGRIIDANIAALRFYNYTADEMRTRHTWQI
NTLGRDVLPVMRSVASLPGGHKPLNFTHILSDGSLRYVQTYAGPVVLNHIRLMLCIIHDI
TEEVNLKEELEFAATHDPLTGLLNRREFYRIVDSSLFHADGFCLLLVDVDNFKAINDSYG
HQKGDEVLLAISRILESAARIQDQIYRWGGEEFLLFLPGATIAPALAMAEAIRHAVSCYH
IPEHAGTVTVSIGVAEHQEGEEIDQLFNRVDKALYAAKKEGRNQVKLHLVEKY
>A0A344SSU4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A736UUY4|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMLLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDAGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6D1SES6|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MHKLTITPADFFKQENPLFNAVVLFSTTVALYAAGRLIRHNDIALFWPMNAVLAGLFIRH
RVLRQFHYFTIFILATLFCSLAVGSRSVSELLTDFSDIAFVAMLSWMIISEKKRCESFIK
ITIFRLYSYCLLTAVACSGPGSYFFSLSHQIDFWRIYPVWFSEEFTTSVLILPFVLICTA
QQPFRPTELRRLIPVGLLAVSLAISIATGTAGSMGTLSMILPALIWCAISYSLPTTCLLT
LLAGVVEVLMVDQKAGGISLVGHVPLIISARLGIASIAISPVIVAVSVQAINTLVRQLSH
QVRYDYLTRVYSRFGLYERLKELHDGERDTPLNVLVLDIDHFKNINDTWGHDCGDKVLAA
FAVRVQNVVGQRGIVARLGGEEFAVIMAGKPGGEGYLLAEEIRKEIESMQVEWGSKMLSL
TVSVGLSYGKAMRWNIVDIFDKLLSEADAYLYQSKKMGRNRTSAPPVTAISQPLASI
>A0A6N2Z490|diguanylate cyclase|EC 2.7.7.65|Eggerthella lenta|TrEMBL
MSDVHNHEHAKENKGVGPASSLRTVIGVIVSIIAVCLVMFAIFRVYSNELSDEFYDLASV
SMDDYTAAQKVEVESFISEVSSVISTMCVLAESPDIDPSGSTFAAYLEEWNQQGSFQVTY
TPIEELEQGVASNRNERDEETLRHLYAGETVVSDVRKSNRLNGYYFSIAKPVNRDGRVVG
VLRSIVKAEKLLDTSQASSQVTLLGTLLIKEDGTVVPVSKEFEGYEGSTLYQVLEGRGVS
SDQIADVRASIENERDVATVMLGKQNGYMTFLTSIRLDVNDWTIVNFTQESSLVEHSESI
LRLTVYTAALLIVISAAACLAVALVVGRIRKRARRSAERYEVLAEFFDTVLFEYSYPRDT
LELTPNARGMFSLSSLSAEGYLAKGIPLIDFLEDDYKRVRMAFENPAPPNELRTITCRAR
VLSGEYRWFSFTCRYLYEGSQPYMAVGKIVDITKQRETEELLTRKSQMDGLTKTFNKMAF
QEKMAALLPETGRGLLFVIDMDRFKQVNDEYGHSMGDRVLEEVARSLLDVFRHRDPVGRV
GGDEFVAFLVGANDDAVIEAKREALSSLIAEASRSLGVPIALSVGVARYPQDGATYQELF
DAADRAMYDEKNEGRVEDSV
>A0A728H3G0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7T7R8L7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CS-2|TrEMBL
MNTESIAVLAAQWKSVCQDFSTTDLNDTFQFIQAHSQTLVDEFYKDIMQEKEASYFLSDD
MVQNRLKTTLNQWLIDCFIVPLQQNFIEIVEKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFLLQTEQTQENRLTIAAYIVQILGFASEIMCRSYEVNLEKNNDTKHTYRLFSAMQDVSA
QKDKQRSSLLDWENELMFKVFSDEPKFTHPLLSKSEFGLWFIHKAAYAFTGTEQVSTIID
RIHQIDLLSQQVLNATEREQAIQLIQHIRENNREIQHLVDQLFQVADYIDLGSDSLTQLL
NRRYLHTIVSREINFSRKNNAPLSLLAIDADYFKRINDKFGHAAGDSALKFIGEVLLTSI
KGSDYAFRAGGEEFLLLLVDSDLVRAKEIAEQVRSRTQETTIRTSIGISFNFTVSIGCAL
YDGHPDYQRFLDAADAALYAAKNNGRNCIQVTKQVASS
>A0A149STY8|diguanylate cyclase|EC 2.7.7.65|Gluconobacter thailandicus|TrEMBL
MTVDTLPITTAPLSPDEMEWQLIIDAVEPAIRLIVADIVEERAPAGVEHFYSTLLNHPEA
TPFLSNQIVNDHLHAALLKWCQSLFTPVAPDLSSLVATQRRIGLVHARIRVPLHVVMHGA
RLLKSTLRQSLFESLTSSTDLAKAIDYVENMMDLAIEMMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREIQRAALLDWGHKILLAICCNAPPPLPLLETSGFGLWLNHKGSLLFPNTG
GIEHIKTAIRRIDQVLIPSLATETPPAAARIHELQAQIEEIRFLMDDLFKKSEALESGRD
PLTCTLNRRFLPTIMAREVAQSIRRKVPFSILMIDIDYFKAINDRYGHTGGDAVLREVAE
KLIASCRTSDFIFRYGGEEFLVALVETDLQRAFQIAESIRESVTKVSTQPTGTALSVTVS
IGVAHFEGHPDYTHLIEDADRALYYAKERGRNCTVVATPDLASLPRL
>U9YVK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 113290|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A1X6ZPQ3|diguanylate cyclase|EC 2.7.7.65|Roseovarius halotolerans|TrEMBL
MRLLLKTRNDVRLFTAVTVAGIVLGTLALHAVMTPRDLLIRTWPVAAAVAAMLAGPLVYI
LGIRMAEAQRLAQRLSEAVSFDSLTGAQTRDSFHARVAAMARGPMTLIVADIDHFKSVND
RFGHPGGDAALQQVAQRLMNHCRAGDLVARFGGEEFVILLPRTGMSSGLRVAERLRTTIR
DTPLRIGARAVQVTASFGVASLTDPRRVELAIRAADAALYRAKEQGRDRVCRGGPDPVPP
PAPDAKAQHFHTRLAQTSQSR
>A0A2X2WFI5|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MLLFDIDRFKLVNDNYGHLVGDSVLRTLASNLSVWTRYDETPYRYGGEEFVIIIRTKTDE
QACRAGLRICQLVADNPINYPDGELSITVTAGITQAQQGEPLDVVIGRADRAMYRGKQTG
RNRCMFMDKDQQITRV
>A0A0X8HBP2|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MRQGHTQIHASRRDVAAALDTERAWTRVALNTVGDAVLTIDLQGAITYMNRMAEILSGWS
EPEAIGQPISRVLLLVDSKTQQTTITSGRRAIEENRAVGLALDGALLRQDGSKLEIEDSA
APIHDRDGRVTGAVIVFRDASMSQVMLDRMAYLAQHDALTGLANRALMTERLSHAIGLAR
RHRHLVALLYLDLDAFKPINDSLGHAVGDSLLQAVAARLRDCMRDIDTVCRQGGDEFAIL
LAEIKKPEDATKVAKKLLAVLSRPYRIEGHELLITLSIGISLYPDDADDAETLMHNADMA
MYHTKRNGRNGHQCYTTEMNTLPIQRRRTEPGVHRSLDSAQLFFNF
>A0A1Y5TXM9|diguanylate cyclase|EC 2.7.7.65|Oceanibacterium hippocampi|TrEMBL
MRNTVLSQVTGDVALDALLDSIVDAVILIDEGGIIRRFNKGAERIFGYGRDEALGRNVAM
LMPAEHATRHDGYLAQYRETGEARIIGIGREVVARRKDGTELPVVLSVGVLEILGERFFV
GNIHDLTVEARLRQLATVDQLTGAFNRGHCLELAAREFNRQRRHGGSIAVLLLDIDRFKS
VNDTFGHATGDLALKGFTDACRGDLRDVDIFGRIGGEEFLLILPEADRTQAELVAERLRR
ATEDIVLPNPDGETFGFTVSIGIACVEPSDEAIENAIRRADAALYRAKAAGRNRVEFRAG
>A0A7Z7VPU7|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNDENFYKKAVAQSEPPHSPQNDHQRSGLRFARRVRLPRAVGLGWMFLPIAAVLASQPIA
GGWWLFLVGWSFVWPHLAWQLASKAIDPLSREIYNLKADAILAGVWVGVMGVNVLPSTAL
LMMMCMNLMGAGGLRLFIAGMVLMVVSCLVTLQLTGITVAFRSAPLEWWFSLPVIVIYPL
LFAWVSYQTATKLAEHKRRLQVMSMRDGMTGVYNRRHWEILLRNEFDNCRRYHRDATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPADNAI
AAMSRVHERLNALRLPCAPQVILRISVGVAPLTTQIGHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A1Y5SEY3|diguanylate cyclase|EC 2.7.7.65|Oceanibacterium hippocampi|TrEMBL
MPGVPATAKSGRTTANGDMSLAGALLETRAFPAAILDRDGRAALRNSLFDTALTSEGLAG
MLEHPAAAEALDAARDPGIPATVTGEFGPGGGIRQLSFTPLADGTVLLDFDAATDGGAPE
GDDPGSEAVILQKSAMLADAERLARIGHWRLVLETGELFWSDEIFRIYGFDRDSFEPSLE
PALAVYHEEDRGIVTAAVQHAIDGGPGWDLTVRLVRPDGELRHVRAIGHVEADSDGKATA
LFGVLQDITEQRDAELARDRSEKRSRLFLEMLPIPAGISSYPDGEIIAENARLPAALGTD
GRSAIGMRTADFYIDDAELAENKVIFERDGSYHNRELHLRRLDGREITIFSSALKFDYEG
QPAVIFAFSDVTDILQVRHSLQESDARYRALIDGSLQGILVHRNLVPLFANDAFATMYGF
ESTGDVTALPTLLDYIDPEMREAVLADSSAVVEGRDFVPSVRIWNTRLDGTPICLDALRK
RIIWQGEPAVQVTLIDVTAQVTHERELLRSKELVEERARQLGEASAQLRETNILLEGAER
AAKLGHWRLDLESGAMHWSAEMYRIHDRDPATFVPDRENARERYLPEDWMRLRAVVEKAI
EESEGYEFDARLVRPNGEIRHVHTIGMLELDWQGKAIAIFGILQDVTEQRRAEEAARRSE
QRFRDFADASVDWFWEMDSDLRFTYLSSSIHERWGIDPTELLGRSRFEIIDATTDAAALI
AHQDDLSNRRPFKDFAYRTNRSATGERWCSISGKPVFDEDGAFVGYRGTARDITEERRAQ
NALRDSESRFRDLIEGSIQGILIHRDMKPLFANDSFARFFGYRDGSEIEALPSASILIEP
SDRAGVAEATARLLAGTETTNRTRLRYRAQSGQVKYADVLRRMTNWHGEPAVQVTMFDVT
PQVEYEQKLEHTNRELTRLATTDSLTDLANRRHFMDTGEAELIRHHRYRTGLSLVMLDID
HFKRINDRFGHDAGDEALRSFARTISPMLRQCDMLSRLGGEEFAILLPNTRLDGARVLAE
RIRERIAATPIVHGAHRFDMTVSIGIAEATRTHSNIQTPLGLADRALYAAKNGGRNRVEV
FSALLDAGVEASGAPREQAAARLAADHGAQSSGKPRATAAETGGDRQKSGTRRR
>A0A120JVR5|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MTEENAMSGGGLGLELPGNVRDFTERLPGVIFQFHRGLDGHMHFPYLAGNGTSLPGIDRD
ALGQDARHMLDRLYDDDYPKLMAAIERSARWRVPIATKFRIRLAHGRTRWVALRAQPEDA
QSGVLWYGLMIDITEQMVEEARLRRLSDTDDLTGLANRRKLMVRLAEEISRCNRHGSPLS
LMLIDLDHFKRVNDTWGHLQGDQVLIELARLCRKLLREEDTIARLGGEEFAVVLPATPLV
RSLPLAERLRHRIGEHPFGIEPGQITVSIGLAEYRPGEPRDVLIERADRCLYAAKHQGRN
RVES
>A0A5W3E9Q2|diguanylate cyclase|EC 2.7.7.65|Salmonella anatum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDSRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NSQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G2WI95|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLITLGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8F9JUU8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MDERASKPPGLLPLSREDLEKTLRYALEIVSDGIWDWNIATDQVSRSAGWYLMLGYPPHS
LPESVETWKNIIHPEDYPRVMASFQAYLDGESPEYCEEYRCRTYSGDYLWISDRGRFVEF
DERGEPRRMIGAHHEIHQRKLVELELQQRNEELFDWNLRLEELVAERTEALHRVNQALAS
KMAEAQRLSEIDPLTELYNRRKFEQCLHHEWMRRQRHGRATALVMIDVDHFKRINDLFGH
STGDRVLVAFGRLIASELREVDVLARWGGEEFILLLPETGLEAAAALAERLRQRVRSQSF
EMGERLTASFGVGVLNDGETLDLLLCRVDDALYRAKQRRDCVACC
>A0A7W6JFW5|diguanylate cyclase|EC 2.7.7.65|Brevundimonas lenta|TrEMBL
MTARVLVVDDVEANVRLLEAKLTLEYYDVLTAYDGQSALDIAGEERPDIILLDVMMPGMD
GFETCRRLKSDPVTRHIPVILVTALDGREDKMRGLESGADDFVTKPIDDVILFARVKSLV
RLKSVMDELREREESGRRFGVDTDGAGRLRGSGGRVLVVDDNALQAGKMVEQLSGEHRPV
HEADPAAALIAARGPVDLMIVNITSESFDGLRFVAQARSTEASRRTPILAVVDPHDRPRL
VKALELGVNDILPKPVDPDELDARARSQIKRKRYADFLKQKLDYSLEMAVTDALTGLHNR
RYMAGQLQALVGRAGQGGDEVAVLVMDIDHFKAVNDGFGHDAGDEVLREFAVRLATNVRA
IDLPCRLGGEEFVVVMPGATLEAATRVADRIRRDVAQQPFPIMGGAESLTITVSVGVAAS
LGTGDTPDALLKRADEGVYEAKARGRNQVIARAA
>A0A1Q2YXI3|diguanylate cyclase|EC 2.7.7.65|Roseomonas sp. TAS13|TrEMBL
MRSVLQRQGLFGPQMPSVARRVTLVVAGVWLVLVTGLSWWMSRYIMTERLSDLAASAEYD
TRTTARIVDRLFTEMSSVANMVAHQSRVIQLATRYRVDPPDLASLTRQQRAAYFTRDPLV
RSVGDFMNSLSSDLRYARIYMNNLSDDTVTASNWAEPDSIVGMIYRERRYLVDALQHGKG
QMFGIARLNRTPSYFVSSRIEDADDVTQGSVTVKFDAPDMALYLAGQHIALIVNRQGRVT
TSSSAPFMLRNVAALLPPDILQPPDGDEDIGKPMDIRAMTGPEQAGQWQIDGHLYLLRRQ
PLSDRTYQLLTLVSLDPLAPMRRQHFWVAGLVAALGLVLILLSGRVAGQMVLQRQEERYA
ANYDALTGLPNRRAILADLGQCFALAKRTRQSILVAFIDMDEFKTINDTYGHEIGDKFLV
EVARRLSAGLHPGDVPGRWGGDEFIVIRLAAPSRPDAPDEAAAVMRRQLAPLLIGTYVFA
GCSFDYPGASFGVATVDPSASSLQAALQEADRLMYADKQARRALRLRVTPRPSVRSEPVD
LIAGRASRPESAGSASPPLSGR
>A0A6W0NUN3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rubislaw str. ATCC 10717|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X4YMD2|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MLKVWQAALLRDLTMPEREKNIHIQPSSSISRTHILPALLAIVAVTGLCAYISSPLGPWR
EILINPGMYIDLLALLFLLFMLWSSTKVRMNHVAVNWVRYGLLLWIAGGTFDLMDEIFHQ
PRWMGYYCEDLLRLSGMLLSAVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTI
REKEGRRLGLMIVDIDYFKKINDTWGHLVGDEVLFALGKQLAKLTSDKVLPSRIGGEEFA
IIVDGMTAQEVDELAQAILQKRPGDPDQPRPSAVDQYRRWSA
>A0A836NCE8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2-460-02_S1_C1|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7H4NYQ3|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MLTGSIFLASCIALLLTHSLHRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFA
QDFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVHSSSA
LLFS
>A0A0D6JE50|diguanylate cyclase|EC 2.7.7.65|Candidatus Filomicrobium marinum|TrEMBL
MRLSQDAKLLLSTLIVIVAAVAASWVALGKARHFILKKEGRYTAVHWAQYLENNLRGLDG
LLSAGLITNEDRMTFDFATATGNVLNYQILDERGAVAFSSWSGDFRLSIPTDHVQAAIRN
DKSYTELIEYEGGESRPRLVAEAYVPIESTAGYKGAVNVKIDLTERAVELERRSMFAFLG
LLGFVTLISTFCGALVWRNIRNRQWAEDLQNSRSVVLEQLATGMPLKQVLLTLVQSVERL
KPDTVCSILLLDESGTRFKDGVSPSLPEFFRNSINGVQIGHGVGSCGTAAYTRELVIVSD
VLTHPYWAGIRDLVARTGLRACWSLPVISSDDEVLGTIALYYREPREPTDAELEFFRTIS
HLVGIAVEQRRFQARIAHLAHYDTLTGLPNRRKLQARLQQYVSEARIANGTMALAILDID
KFKTINDTYGHPVGDSVIREAARRIAACVREDDIVGRLGGDELAIVFRKVSDVREIAEVS
DRIAEAVRLPMYIDGKSIATSSSIGVSCFPQHASDSDELFIKADHALYQAKQSGRATCEI
YDEELHELIREKQILERDAALGIQKDEFSLVYQPQIDLKSGALIGLEALARWEHPVLGQV
PPNKFIPIAETSPIIIELGERLLRQACTQAARWRQGGLTNVKIAVNVAARQFKDPLFVEK
IKNILEQTDLKPCALELEITETMLIDDFDVVEKTLGELNALGTSVSIDDFGTGYSSLLYL
SKLPFQNLKIDRSFVHNLPSDSNSVAIVTSIIAMARQLNLSVIAEGIETCEQAEFLRMNE
CVGGQGYLFAQPMDALQLETWLRDDFVNTFHGRLGAMNGQMEAARVASLKHSELRSA
>A0A173TQC2|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MDDMTGLYSKNKLLETVEHMEPKERPVAVIYWDINQLKYVNDTFGHLYGDQLIAKIAGSI
RAAVTSEETNAYRYGGDEFLMIIPDGTQEIAEDVIEKWRQVMKPIQKNSEIPVSASVGYA
VGKYENIMELIEIADQRMYKDKQLRRQ
>A0A7H4P159|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MWQTFPDDESQREMQVVTASIPLDFQRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQL
YDNRLNLIASSAPGNVLTLLSPREQEMLSRASSHENQGGIRLVTRYISWENLRNFDGVLI
RIHTIQEGVRGDFGSITIALMLMWLMFTLMLLISWLVIRRMVRNMSVLQTSLEWQAWHDA
LTRLLNRGALFERAIAETRLSERLKRPVAVIQLDLDYFKSVNDRFGHHAGDRVLSLVAST
IASHIRQGDLAGRVGGEEFCIVLPNTPLKEAQVIAERIRIRINSREILLGNSISLRITAS
LGVSGSDDTGEYNFENLQSVADHRLYLAKQNGRDRVCAEG
>A0A8F9XDR7|diguanylate cyclase|EC 2.7.7.65|Pseudochrobactrum sp. Wa41.01b-1|TrEMBL
MTDRAVILIVDDEISNIEIMSAVLEDDYEVCFATSGEEALKVAQTVLPDLILLDVLMPGI
DGYEVCQRLKKDRMLADIPVIFTTGLNDQDAEVRGLSAGAIDYVTKPIQPVILLARVANH
VELKRLRDQLAQMAVTDALTGLSNRRHLEQTLATETTKLARTGDWLSVIMVDIDFFKLFN
DTFGHPAGDRCLAMVAAALTRAVHLATDVTARYGGEEFVCVLPGRDHDAAVLVAKEIQEQ
VSSLRIPHPGSTVSPCVTVSIGVASACCLPEMSASQWMAHADRQLYLSKRAGRNEIFSTV
FNAQEIGLISE
>S0G0J2|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MAEIPVPAMKKKHLWKRFFINISLIVVLFLVGIFIGFAVQTDRLISEQYLTTARAHFKNI
VLTRRWNAEHGGVFVKKGPDNPSNPYLENPDITAKDGTVYTMKNPALMTREISEYARQSG
DFVYHITSRIPLNPDNAPDDFERSALSGFEEGNRETYVLLKDNTRSIYRYMAPLHVEDSC
MPCHAKQGYRIGDVRGGISVTFDVSDTEKKMARNRFGFIGLGIAASLALLGIILFLISRL
AGSLSKAYNTIEKMSITDELTQVFNRRHFHARLDEEIARARRYGHPMSLLMVDIDHFKTI
NDRYGHQTGDDVLKAISVLFGSNTRSADIVARYGGEEFVVLLPETEEETARVTADKLRAA
IERQAFTSPDRSLFHVTASFGVSSLHMTDQNTADMADRMVKMADDAMYQAKQAGRNRVVV
SSGM
>A0A424W9Z9|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSTSSIGVPPTSDRHAGSSGQACYLSASDEQAWIAVYQSVDAYTRGQVAAVVGDSLSALV
DAFYSTLLADAEAGPRLSHDIVSSRLHAGMTRWLKGLLCVRDQGDIAALMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQSVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPGLQQITDAVAQLDGVVLPQLMRGEEQGLAASMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSSFSVLLLDIDHFK
AINDQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAQQEAALATAEKLG
AEIRRHVFTIPEAAPLHITASIGVATFDGHPDYAYLIDRADQALYQAKQAGRDRAVAA
>A0A448IXQ1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MAVGGPEDAAFDDVLCRSVQAALDCGRALVSRDGTAVARHLWPGPGAVLIIEDARRSSHP
ARSAFPGAGFVGAVAIHRGPDDVVGALWATDPQPRPATPDLRRRLADFGELASLHAQRAA
EATLYRLVAENSADTLIRGNLDGVRQYVSPSISELLGFDAHELVGSRARDITHPDDVEAF
GRQMLAMRDGHIDSFITEHRMSHKDGSWVWLEAFVRVTHDPVTGVRDGYVVSVRDTSRRK
ELETRLAHNASHDTLTGLPNRALLYERLQEQIDRCARHDGDFAVLCVDLDGFKKVNDELG
HSVGDTVLTAVGERLVSCVADTDTVARRGGDEFVVVHQSGAPLLESAVALAQQLIDTASA
PLTIGEWTGSIGLSIGIVTGGSTSSGEELLRAADRAMYEAKAAGRNGYRIA
>A0A7U1KW36|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0W0SHC9|diguanylate cyclase|EC 2.7.7.65|Legionella cherrii|TrEMBL
MYFTLIMIIIGIFFLLGGAIVVWPLIKKASYYHYQWIANLVLICFFIGSFLFVIVYTLLI
NEFFTNYFYATLFLLGGFYVFWMSYLSSKTIEKIKTMDNLKLEYEKIRYNAEHDKLTGCF
NRHYLMEILDNRFRKIKLNTGQLTVMFVDLDGFKKINDEYGHDFGDQILQRFGQLLKQQL
REEDIIARYGGDEFVVLVENIPLTKAKSIGQKIIQTTSRITKEKLPNHSSLGCSVGITQL
TKNSLSINSVLKKADDACYKAKKNHGNTIWVDDNMTSSFLD
>A0A8F7Y3P7|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MDVLEQDIQSQLHNLKSQLEQVRLTQRDTSFKFKREQKVLKRILASLSDACGGEDPRLKS
GLTELRQAIEQQKDVSSLIPKLAVLERLLKQQSVAMEKQTEHLDSQIKHSGETLLRVTGL
PAKVKRDLRDLLSYSSGVERPKADSAMKLLAIYERSLKIITSNPDSASNQITSSADKELL
LRLSDELQHVITELDFEGESGDLLTDIRAKLLLGVNTHVLIELTLQVLKLVIDGTKYERK
TSEQFLEQVNASLSSTLKSSSQNVDQSQTYFEHRQDMNSELDELVAETKAKVDSASSLDS
LQTQLNPILAKLSSLSERLHHAEQREQALIERMGYGKNQLEALFEVTQDYRRRLEDQAQR
VLLDPLTKVYNRTAFNDRLELEYRRWIRSQNNLRIVMLDIDGFKSINDSFGYTAGDKALK
IIARTIKKELSDTDTVARFSGEEFILLMPDGSDSDCFNTIQSIQSKVAKLPFKFREQNLV
ITMSASSTGFKESDTPEEVLERLNRVLNEAKTIGPNQLVWK
>A0A1E3GV44|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MQNRKRIFTLTISSLVLLGFMATSLIGYFVARDSTSEQLQKQMLPLTSDNIYSEIQRDLL
QPLLISSLMANDTFLINWAESGEQDPQQLSDYLAQIQRKYNTITAFFVSEKTRNYYHPKG
IIKQVDETDPADSWFFKARKINTDYDINIDWDTAAPNRMSIFVNYRVINQQGELVGVTGV
GLSMEMVAQLIENYQRRYGREIYFVDRQGEITLRSSLFQDDIYLQNKAGLDQLFMQILSN
PSASVSYAAKDGNTIYLNSRLVPEFDWFLIVEQINDPATDRIETALWINVGVSLAISICV
LMLAHFTIRGYQRRLELMASKDKLTGATSRQVFDWVFDKAQKTALRKDWSLSMIVLDIDH
FKSVNDKYGHQFGDQVLKSVSRLIKQKVRDVDVLCRWGGEEFLLLLENCDQQHAARVAEM
IREAVSELQIRIKDESISVTISAGVAEYQLGESMDNLIERCDHAMYESKNKGRNRITVY
>A0A1V5FWG9|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MHEHPTTQRTIFSPGPLSPGPSSACLVVIHGEGLGKRQDVREEVIKIGRAPDCTLLIAHP
SISRRHCEVWREDGRYWVRDLGATNRTRVNDRPVERMELKDGDHLTIGETLLKFISHESL
EARYHEEVYQLATQDGLTELANRRHFAAQIDVEIVRSLRHARDMALCMIDIDHFKPINDQ
FGHIAGDLVLKQMAAVIRGNLRREDLAARIGGEEFAIVLPETAAENACVFANTLREAIAA
EIFVLGGEPRHLTVSIGIAGLGPHANDRSSLMRNADKALYHAKDAGRNRVCLCASEDCVC
KEAASG
>A0A1E3GPK0|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MCKEYSDKSPNTSQKRLFLLKNKQGDEFEVQLNCAPLLDTNRQNIGWVVALQDITQNSRL
EKMLTFQAVHDTLTGLINRREFEKRLESLIYEAHHDKAEHLLCYLDLDQFKLVNDTCGHR
AGDVLLKQLSSLLKPVLRQSDTLARLGGDEFGVLLTHCPIEKGLDIAETLRKTVTAFRFS
WDGQVFSVGVSIGLVSITEASGSLDEVLSHADAACYAAKDRGRNRVHLFQPDDIQAQERQ
GQIQWASRLQEALDKDLFRLYFQTIVPLENSDNTMPHYEILARMIGPQGEIIPPGAFIPA
AERFGLMPKIDQWVIRNTLAWMGDQLRQNQQPVFCSINLSGASIGREDCLQLIQEQLEKR
KVPANNICFEITETAAIADPANAARFITELKGLGCQFALDDFGSGLSSFGYLKQLPVDYL
KIDGIFIQELANNRIDQAMVASINNIGHIMGLKTIAEFVEDAATLNILRQIGVDYVQGFY
LSRPEPLESLMSVRVMPR
>A0A839PGV6|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp. RMAD-H1|TrEMBL
MTARILVVDDLPANVKLLESRLLAEYYDVVTALSGREALDICQSSNVDIVLLDVMMPDMD
GFEVCRRLKADPKTTNIPVVMVTALDRPEDRVRGLEAGADDFLTKPVNDLQLISRVKSLA
RLKNLSDELFLRASAAREAEIEALLMSRTEDVKARAKLLVVDEDLAAASRLESLLSKDNQ
VDIITEPSSALISVVEGGYDCVIISTGLSSYDPLRLCSQMRAIERTRLLPIILIAEHGET
GLVARGLDLGVNDYLMRPLDRNELLARVRTQVKRKRYNDLLRKSLSQTIEMAVTDSLTGL
HNRRYLDSHMSMLFTRSISRERPLSVLMTDIDHFKRINDTYGHDAGDDVLRDFAGRLHRN
IRGIDLACRYGGEEFVVVLPDTDAQMAAVVAERIRGTVASTPFLIRNGTMGVDVTISIGL
SSLQPRDDSVEKLFKRADIALYEAKKNGRNRVVGAVA
>A0A2T0BIG8|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MKQYGYIYNNFNKMKAFVNTMDISKSDTILLQIMTGIIEVEFIKKLIDELIVLLPNSEII
GTTTSGEIYEGNIYTNSTTLSFTIFEQSKVKTALINNKTTEYELGLYIGNKSVEEDTKLM
IMFANGLLISGDDILKGINSVNNDVIVCGGKAGDNDSFKETFVFTKEGITNKGIAVAFIS
GDQLSITTESSFCWSSIGKEMTITKAHNNTVFTIDNVTAVDIFKKYLGEDVVKNLLMYST
EIPLIIKKHDMEIARVVSHCSDDGSISFFGNVEIGDKVQFGYVDIGSLTVKPLEIFNYLK
DKSLEAIFVYSCSVRRALLQKGVELEISPLVKIAPTFGFFTYGEFFSTNCSNELLNLTMT
ILGLSECGDTCKKSIVELDNNENLNKHFFEHKELVSKKMFINLVNEVTKELKEANEILEE
QKSKIEKIKDITNSIMDINMQLLSSGEFGSLLQMILDKALEIISGANMGSILIMENNELH
YKATKGYVLDNLEKATYKLEDTHQYRLCGKYGLFEPIIITDIEHYPLGSEESHKDWLTIA
TEEPSEILSCVIGNDGEIMGLINIFSTTKQDKFNDYDKALIKHLANDISIAYKYSKLLED
TIYMSRYDGLTKVLNRHYFRLKLAHVINKAKVLHKNIIICELDLNNLKVTNDTFGHEAGD
ESIKYLTDIFRTRIGANNIMGRTGGDEFELVFTNKNKSEVIALIDHIYDLCKTNPIDFNG
QPIEISFAYGLAELYVDSEDIGELLKLADNRMYEKKRIMKAELRNK
>A0A2T0BKR1|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MKTNKIKKSMNNLGTIIKILLFLIVIITLGLNLILNNIIISKYFSRIENGDVILSTNQSS
KIFQSKIKELERITQDYAFWDEHYSKVQEVNIDETWYKENFTEWLPDKNGIDLIVILNRD
KKIIVQNGLNNINEILNDNNILKSLNENEYNEKSIITGFKMYDGEIYMISECPIFKNTTE
GNCHGVVILGKKVSSLFVQAINEDLGSNIFITYENGFVSNEEISEYVNSNIVLINENKNN
PVYKIDNLKIIGSLPIIDISDNNIGYMNVIQSRDTFLSAQKLLQRNSFAVMILSALIILI
LGFRFKGIIVNPIKNLENQIKSMKNNNLLIHVNVNGTNEVISLAGSFNDMVDKIYEHKKE
NQELKVCVNTDCLTSLYNHRYYFESIKNKLAEGHKQIAVMFCDIDKFKLTNDTYGHEVGD
YVLIETSKIIKDEVKDMGMVFRYGGEEFVVMMCDYTSEEALIEAEKIRKRIAENQDIQKY
SDYFPITISIGIAFYPKHALDAEGLIKKSDTAMYYSKQNGRNQCNIYNENMNVFLKDDNK
DINRELLMDSVVALAEAEDAKVKYTGEHSKMV
>A0A8E2NYN5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWPRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEIQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A1S9J8I1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MLFISFSGSLVSRIPGAVQSIAAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLT
AHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLD
LNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNV
MSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQS
EDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A8B4MXB2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MPYSLREFSFPTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIGSFAGAFTGYMIADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGALFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKNHLKGNRIYIKTIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLGNTISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A398Q4P9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A333VEX9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKNQEELSANLNLIFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
LIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAINYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMILQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A140LDV4|diguanylate cyclase|EC 2.7.7.65|Fervidicola ferrireducens|TrEMBL
MIYKGRKLCLASVENIAERLKFERAIKEKEKLYFELAENAPVGILRCDNKGNILYVNNKL
IEILGSPGEEETKKINLLTFPLLVEQGLSGKLEECLKNNEIGTYELEYTSKWGKRVWIRV
HIKPEEEDGKVSGALIIVDDITEKKEMEKELYLLSITDALTGAYNRRYLLSKLEEEIERA
KRYGEEFSIILFDIDNFKKINDCYGHIMGDEALRRVAKVVRERIRKLDVFGRWGGEEFVI
VLPGTPVEKAAILAEDLRSNIADIVLPCNERITASFGVTEYEKGDTIDSLIKRADDLMYK
SKNEGKNKVNYLKK
>A0A3D1C7I1|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A377YIY2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFFRN
IMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVNFI
DDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLS
TAGELNQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNR
SFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVD
DAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNSVT
AEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A377UW99|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQNGKDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKRSMTNGAIWSATAP
LST
>A0A378BGW3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKTLLRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A377V3Q7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIR
LMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRRSFTVWLRRQLLSPGVIVCC
>A0A486D4F7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MMCRSAPGVGRFGACMLLKELAVFDVLSTPIWVVHPFTECVVYANQASRTLSGDMSLNEM
RNGIYSTCPETQLQHYLRYLDAMTEIYEVWTLQTAKGLQSVYCKTTLVETEDSGTLLLFE
AVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPQKEGRIVDANIAALRFYH
YSDEEMRTKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGSLRHVQTYAGPVV
LYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFYRLVDAPSFIAHGFCLLL
IDIDHFKSINDIHGHQKGDEVLLVISRILETSVDREDKIYRWGGEEFLLFLPHSPIARAL
MVAEAIRQAVSEYQTLSVTVSIGVAEHHDGEAIDQLFYRVDKALYAAKNDGRNRVTRMPF
DSAELLRNSGGAA
>A0A486QM06|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPECLIPAKRPIPSALARGTLLPALLVIVAVAVGCALVSPPIGTWREILANPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEMVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDTWGHLVGDEVLFSLGKQLAKLTSEQVLPARIGGEEFAIIVDGLSEPELHDL
AQAILDNARTILINHQTPLSISIGVGTWRSGEAQETFIRKVDEALYKAKHNGRGRVEWAQ
YSDTAG
>A0A1V5QPL5|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MHPLWIPATGLVCAAVGLALGLRWTRRRGPDPRIQERLEALERARDTAELANLELQEALN
ELEQAAGTDRLTGAWNRRRFEEAAQGEMALARRRRDPVSLIVLDLDHFKRVNDTHGHAAG
DTVLQGAVEALRGVLRTSDRVVRWGGEEFLVLAPATPLAGALALAEKARAALAEREHPGV
GSVTGSLGVAEHRPGEMLEAWVARADAAVYRAKEGGRNRVEADGESGPALETGRPLLEIL
WEEAYASGHATIDTQHQKLFQLANALLAVAGPEDSHQELSLRLRTLLAHTAQHFHDEEAL
LTQARYPDLPEHAAEHQRLLRAARGFLADVEAGRLDLAALVAYLAFDLVRGHLLTEDRNY
FQHLVK
>A0A8F2J9F6|diguanylate cyclase|EC 2.7.7.65|Eubacterium sp. MSJ-33|TrEMBL
MRFLQKQYNKKWMLPLLTFVVGCLILTAFIHHSYDTNRKQVRMITELNASTYAERLRDDM
NRGVAIADALKAIIISGNGTIDNFEKISENLMSDFVQSIQIAPDGVVTEIYPAEGNEAGK
IDLLHDENRGEICRYGRDNNCVTMQGPFDLKQGGRGIAVRYPVYLEAADGNPVFWGFTIV
IIRVPEIFEESVQALTEFGYDYCLTKTVSPLSEERERLSFSKEDLTNPVTYTFEFGGCTF
NLAVTPKDGWKQGRKILPNLVLGFFIVLFLTGLMIVILVIEFHREVLKKIAITDPLTGLL
NRDGFDEQIKSAIQDTPDAHCVGIQTDIDDFKFINDMYGHEAGDTALRILAQSMRNAFEK
DAILCRNGGDEFSAVLIGMTGAEAKEKIEKFTMQPRYITQNGEKRPFYISLGYAEYPKDC
DDVSELICCADMALYAVKLHGKHSCCAYEGNYKVQNRSQLGFALQDVSRNLPGAFLIYIA
DKTNDRILFANQELIEFAGCKDFDEFLAYTDQRFRNLIHPEEQDAVETSIWKQIDSEKSG
NNDYVKFRFAKKDGTYRPVFDHGRIVKNRYYGNVFYVLIMDCALIDSYYDKM
>A0A3M2RFH2|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MAFDSQNLDAFHWLADMIETVEVGLVVLDLEFRVQAWNGFMENHSGITATQIRGQQIFNA
FPDIPKAWLTRKVDAVTTLNTRAFTSWEQRPYLFKFRNSRPITGTEEFMYQNLTISPLTN
SSGKVDKVCLLIYDVTEFASSKRALERANEQLAKLSMTDRLTGLLNRGTWENLVDAEFER
YGRYGQTTTLVMFDIDHFKAVNDTYGHLAGDDVIRHTAQVTRDSIRQSDSAGRYGGEEFG
IILPETDAENAHILCERIRETIAQSTVNTTAGDIRYTISMGIAQLTGEPENYMQWMQEAD
KALYRAKEGGRNKVVIYA
>A0A8G1LXD5|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MPALTIRKKLMTLLSSWQAYCQAPNEEHFVEFALGVNTLAELLRAGPSLGLARMSHDLEQ
DALALFNTPDSHPISFEAQARLAEQIENLSQLIKGDVLATQPERRQQADAACYEAKKASI
VLLSDQPSQWQDLIAQLGYFGLAIDVLSWSSAPQQSQALLLLDLKFTNDWPARLSVLRAA
NPASQMIALGLNSEFNLLHQALQLGCDHCFVQDMSLPAMVAHILELQSCQNEEPYRVLIV
DDSLTAHAMIRRALADQGIETQAIIDPRLVIERMHEFQPDLLLLDMYMPDCTGVEAARII
RQHPEFLSIPIVYLSGETDLGLQVEALRLGGDHFLTKPFNPVFLNAIVNSKIERYRTLRR
SMYHDSLTGLLNHTTSKSHLDLMLEQCRAQQRPLCVAMLDLDHFKQVNDSYGHPIGDQII
RSLAWLLKQRVRQGDILGRYGGEEFILALPGASLAVGHSILEQIRQDFAAIRHPFGDGYF
QLSFSCGMAAYPAIEHSDQLIEAADQALYRAKRAGRNRIECA
>A0A3M2RC36|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MSSQIPSTELPDEPDTNSPAAMISAGGLQAVLDNLDALVYVSDFETHELLYMNAYGRQRW
GEIDGRKCWQVLQNADGPCSFCTNHLLRTPEGSPTPPHVWEFRNPIDQRWYQCRDQAIPW
PNGKLVRLEIATDISERKQIELALQAAHERAQTAALEDELTGLPNRRAFFQFGKQMLHQA
LRNRSTLSMVMVDLDFFKRVNDTYGHQAGDEVLIRVSEVMQARLRDSDLIARMGGEEFVL
LLPETPINKACEIAQQLRVIIRALGVLHEGHTIELSASFGITSNRPNDPNLEALLQRADQ
ALYQSKEQGRDRISIYTD
>A0A149VXV5|diguanylate cyclase|EC 2.7.7.65|Ferrovum myxofaciens|TrEMBL
MSEQDANKERLELALEAAGLDLWENDLVTGEVICKTSKVFTELGYGEEESLSFMDDVFKI
VHPEDIPLIKTAINNHLRGIATQYRCEFRVLSKSGAWVWYANYGKIMDRDENNSGRRFIG
VTFNIDDRKRNEEMLAVRGQVWRTLVENSPDTIARYDRECRRIYVNLALSTLTEGGEKFL
LGKKPSEFPGGQDYVDYEAKIQEVFETGRDIEFELNIKSRTGKELCNHIRLTAEHDSSGS
IVTVMGVGRDISELNIQRQKINEMAFYDSLIGLPNRRLLIDRLQHTLASSTRSSLHNALI
FIDLDNFNTLNDTLGHDIGDLLLKQTAQRLTACMRQEDTVARMGGDEFVIILENLSNHIQ
EAEFQVETINKKILTILNQPYQLANHNRHITPSIGIVIFSGNQFSIDELMKRADIAMYQA
KKSWP
>A0A1V5UQ30|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin243|TrEMBL
MSGFEKIFITNELLSALAGSLSLNEAFKKIFIILENHLKIKGASVVIYNPIDKEFDIQPG
FQYKLSKSRIAKLVAEKKFDLKTAGIFDISRHIIPDDLDGEMSFLYFPLFVNSRLSAMLL
LYIKNSDISDTKIDANLVEAISTPISIIYERELLFNETKVQKNGFEFLHKLSNAVNKTLD
VESILRISLKSICHNYENIVAVIAISRSQFKIIAAGSQKCFDIESNFPTILEELKENLNE
DISNFTIIKEMPKFKDEESEKKLKINIESSMWLSLNYNNNIYGYLGLFSSGRELEKLSVS
AIRFLTLASNHIISAVENARLYNEVERLASIDGMTGVFNYRYFYSHLTTEIQRAKRYSLA
LSIIMLDIDHFKSFNDIYGHQAGDDVLRAVGRILMDEARKIDIVARYGGEEFILVAPETD
LPGALGLAERIREKIEKNNFKVKSKNDTLSLKVTVSVGVSTFAENIPCENDSLIKAADDS
LYHAKHSGRNRVCYNESGDLKQFRRNQ
>A0A6B8N7E6|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MLIKRRFGWIAVLLFAIWFLPVKAQTPNYKVAMEADDVVTRVLFDAVASKFQLDVQYVYY
PSFDAILDSVKAGESDFAANVTYTPDRALYFDFSSPTNIEYTYVYSATNATLDKLHTVGV
PKGTIYGELIRKAFPAIALVEYSGQSEALQLLKQGTVDGVVDAINQLKPMLLAGYDAQLL
NHQLSIKPVSIVSLKGAHHQLLKTIEHYVHSAEVQKLLRESINQYQFEIRQQALRQAVLN
SGINFNRPLRVKIENIGQYATYLNDGSIAGITADIVLQACDILMLNCKLESTADESWESM
YGDLIAKRIDVLSPIAISEARKDLVYYSDPYYQPEAILVKREGYKDNVYSNVSELIVERI
GVVKDDFYEELLRGLLPKKTLLTYDSSESQLKALMNHEVDYIAISRANFNTLLRESKDLL
PLTEDLLIGGYYTSDIAIGFAKNQVGASLAPLFSRALKMIDTERIVKRYDYRPDWKATLQ
AEQSFSRQSRALFMLVLGFLAIVAIYLHSQSTTDNLTRLKNRRSMHRRFRSGINAHYTLL
YLDINRFKFINDTYGHEIGDQVLKAVARQIELYWKGNSYRIGGDEFILIGQPEEVTLNAL
IDKLSSLHFVSEDHQVSLDVSVAIGISCPRDRFMTLQEVLNEADQAMYDHKREKHRCIIS
RQSNEQNVVHFSKGG
>A0A1C3JQX3|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MQKKRLSYYVFFSIVLIGTITLSITSFLWIGNIYQTYQREAQRIQENYTNEVKDELKNRV
DTIVSLINYRKATTEARLQKNIQSRVLELNGLMTYLYESNRDKLPDSDIKKLITEAVRGM
RFNDGRGYYFIDTLQGDVILYPVAPSTEGSNLFYLQDERGNYSLQQEIQLVNKHGKGFIE
GYWTLPGEDTQKDHKKITYVHKFAPYDWYFGTGEYLDITTREVQEEIKSYINQLSYGDDG
KQYVFIHDFEGNELANGRFPELIGQNHYEMTMSPKVQYIDRQIEIASTAPHHGFLTHLWP
NFSNGNTSNKLTYIAAIPSWGWAIGSGANMEDLNNAISRHQNELYNQLISGIQKALLLAA
GIFILSVIAARYVSKKMNASIKLFTRNLETSSAQLSLIDEGKVIYQEFEELAKASNNTTQ
RINTLLHKDELTGLFNRRYINVLFDSLLQQAKKDDSNFSLIMLDIDHFKRINDTYGHPFG
DQVLMNIAQCIATEVSTKGYVGRFGGEEMMVLLPNYNAEQAFEIAMQIKTCVEQIRLPGQ
DFSVSISGGISSGTNATTFELIQQADSKLYCAKNNGRNRIER
>A0A3P4AW31|diguanylate cyclase|EC 2.7.7.65|Pigmentiphaga humi|TrEMBL
MSTADTLLALAHPLVAFLIAALLTGGWHFMGRPAQLLYFAGAFVCYAAGLTLQITLWPAD
LAVNITATGLLYSGATYMFASGITQLERKPMPSWPSAAILAAMLAVRIWSLRDPAWSGLR
IGTLYTAVTLLFLLALWRIRHLGRGSALERLLFWFVLLGTLSLMPRILLTLDARTTHYGY
DGGMYWVLTQLSFYLFSVGAAVLLLLLTAFRTIAHFSRVSERDPLTGLRNRNSLIRFLEK
SLAKADRYGLVILDADHFKQINDRYGHPVGDAVLRAMAGVLALHLRKADAAGRIGGEEFM
LVLPGAALEETEQAAARLQAAMAEQDFSSIAPGLRCTASFGAGSFGRDVPFEQAYAHVDR
LLALAKRQGRNRIGKAATEPAGDEDTQALPPVIGFTGEDSFSTMNR
>A0A1C3JS75|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MLQPTTCDQKFAITHVLDIDALRNVLRRFQSASGVSVWISEQNEQFIVAGSSHYDASFCF
QFVVHIDDCLPVVLSLDGRSFKVGESTLPLSVPTVVNTVRAGIVDVLQVMVEKELLARKN
SQNDIQLESPFHLQTILDALPTPMGWSNAENDNIEYINAAFEALFGYKQADIPNLQQWFE
KAFPDEAYRQKNRLLWQEQIVQRKVGDKETKMQPVEVTCKDGSVRNVLISATSVGNKRLV
NYSDMTSYWQIQNRLSAHREMLEMIAKGQSLASILEKIVFQVQSESKDSICSVLLLDEHN
KLRSAAAPDLPEFYTKAIDGLKIGPSVGSCGTASYLKERVIVADISEHEYWRGFETLAAR
ANLAACWSDPILSSSGEVLGTFAIYHPYPTHPTQNDIDLISFASNLASVAIENRQSRDEL
ERKAYYDDLTGLANRRYFFEYASKVLKELLDGNGYYSMIMLDIDHFKLVNDQYGHEIGDL
VLRKVAQTMIKTLDDTGLVGRIGGEEFAVILPHIGKQEAFDIAECLRIAVSQLMITTPSQ
GHVKVTISAGLAQCCEGEEGAIGIDQLFKRADTALYQAKTAGRNRVMVFNTTQ
>A0A485CGC5|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MSLPPPPLLRAYLELMAEALGLALANQRLRSALLEKALFDSLTGLRNRHHLDDALHTQIN
LAVQNHAPLSCLMIDIDHFKTINDRYGHEAGDLVIKSVAVIVQRAVRDKGMAFRYGGEEF
LVLLAGANEETARACAEEIYDSVRSLTLRDGLTEIGQVDVSIGIASFPQHTQSDSLLRAA
DAALYRAKRAGALPDSQFRHAEIRLKRHTGISCLLIPATANGWLIPPFHQR
>A0A1C3JTC7|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MSISNNILHHIENFTAQRDKELLAFSLLKSIRDILNPIRISILTLNGQDEPIMEISLSNG
ESCDYRYQDIKVSDSTRASLDYINTWHLDELMKAHDDQYTSFHVLQQSRQLNQYLIITLD
NKPSRSESYIIKGMLSIYSNFSSLLADAQTDELTGLMNRKTFEESIIKLYQGSAFSELTD
SHTNWIAIIDLDHFKVINDKAGHLYGDEVLIHVSRVLRQTFRQDDMLFRFGGEEFVVLMR
NLTRQECADLVDQFRTSVQEIAMHDLEPITISAGICEFLNDTFHITLMDHADQALYYSKQ
NGRNRITFYDEIVEAGLAKQNNVTHGDIDFF
>A0A1C3JMN2|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MPQRTGSLLIPLFILLAGLFASVYTTQFPALALDLLPWLPYVLSVVMVFMAWHFNRGKVL
LAGGLLLLPTFYPYVSNHDLPNSFTTIAAIGLGLLLLLRERGFFNRYGFNRILFLGMLVA
WSMSYEKGVINFNFLAVLVPVVNITLSSLLCWLMIGFTVMTSLIFWWRHADGFSTAVLIS
LVSLLLIECMSFTAHQDAAVRSAQILVWVWFVVSESHRMAYRDELTQLPSRRALNEAMLA
LPRHYALAMLDVDHFKKFNDSYGHDKGDDVLKQVARVMQRYSGSASVYRYGGEEFTLLFK
GRGIEHAEVVLEQIREEIHLQRLDVSTETKHKEVSVSVSMGLAFVNTGEAPNDVLKRADQ
ALYQAKRKGRNKVILAS
>I3X1G8|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MNSHHHPNFCINEDGLKSKDMAKDITRLIELFETSPVLVAAYDEFDRLRYANAAFRSAYF
IEADEKPLWPDLMRRNFHAQRGTVIRAGDFEEWLRSTQSRRGKVGFRAFETDLFDGRWVW
MTETVEKDGWMLCVATDVTGLKAKTRTVRQDRDLAIKASYTDELTGVANRRFVTARIGDM
LQRHGGNQASPGCLCVLDIDRFKSINDQFGHQTGDSVLRDFAMRIHRLVRRTDCFGRVGG
EEFVLTLPATPIEQAKLILERMLASVRKSRPLQERPDFGYTFSAGIAGAQSGDTALSLYA
RADRALYMAKLAGRDRIHLDESDPNRSAIAG
>A0A517U095|diguanylate cyclase|EC 2.7.7.65|Lacipirellula limnantheis|TrEMBL
MTLAQVLLGQGLIVDTTALAAVALVGYLFGRRTRRAAAATPDVTLLIELARAQCVAKDLE
HLAQRLRTEAQGHLASLAAFQGQVERMQTGAVTADWRQLRQHADALIGQTMSLASSLSLA
CDEMRDHQSQLMTFADARVDRETGVLNRRALVEHLQARLAARGEGAKKVAIVLCSVDVDP
YAWSIDGEAGLGSVARLIEQYARGNDVIARYGPQEFVILLPRTTLEGGLVVGERLLKIVD
AALERRVWAGVVEAEIEETPEELLARAESALRAAAKEETPTLYVHDGAVTRRHAFELMHA
HSGRLAASSISSSSNGAANGAESETVG
>A0A1X7J8M5|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. NFIX57|TrEMBL
MIGNAFERFLSRYKRPQRVVNLCFIVVFLCSTLLTWREVAVLESAYIANQRNSLDNIATA
LDRQLQHSIDNLLFYRNTMHYALQSPISTDISRQALADFAVQRTQPYWQLKLDLNRGMPI
NGVSDEFVSHSHVLDRDEAWLYPELEAALEFSYIMQLADDKRDLQRRVFYASRAGFFLSS
TPPENDPAIVSLYYRLIAQPYFGAQSPQNNPGRGLQWTHTYNPASSNGQIITASVPLDLN
QRWYGVLAMDFPVSGMHAFLQGLSHDRYEGTVMLFDKHFSLIATAADSAPLSPVFNARQQ
AEIARSMESGEEGELRMDSRFVTWAKLGNFDGVLIKVHTLGEGVQGEFGRISIVLTVLWL
LFTLMLFISWRVIRQLVSNMLTLQQTLSWRANYDTLTRLYNRGAFFDIAHGMAQDCQRED
KPFSVIQMDLDFFKGINDRYGHHAGDRVLSHAAALLASSLREEDVAGRVGGEEFCVLLPG
TKLPEAAAVAERIRHRINTKELLLQAGQALKISASFGVSCAHERHDYDFEHLQSIADRRL
YKAKQNGRNQVCTQD
>N9DHW5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii DSM 14964 = CIP 107468|TrEMBL
MNTESIAKHAKQWKLICDDYSVDILNDAVQFIQRHSEILVVEFYKNMMLEKEASYFLSDD
IVQNRLTKTLNQWLIESFNAPLQHKFEEVAAKQQMVGKVHARIGIPSWLIMRGIREIEKK
IFSLKAESQYAENYTLSMISYIFQILGFSSEIICRSYEVNIEKNNDIKHSYRLFSAMQDA
SVQKDKQRSSLLDWENELMFKVFSDTQRFTHPALSKSEFGLWFIHKAAYAFSGSEQVDEI
ISRIYEVDLLNNHVLECGQKEQTIALIQQMRSKNREIQHLIDQLFQVAEYIDSGNDALTQ
LLNRRYLETIVSREIHFSRKNHSPLSLLAIDADFFKRINDKHGHAAGDLALQFISEVLLE
SVRGSDYAFRIGGEEFLLLLVDSDLIRAQEIAERIRKRVQDTPIRSSLGSSFNFTVSIGC
ALYDGHPDYQRFLDAADAALYAAKNKGRNNVYLAKLSTQ
>A0A1V5U186|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin248|TrEMBL
MLRLAALSLALVALAISIAFVHYNKLSENYAEQLFSQTLVGGRAPQYEAARAAANWLGAF
MAALLAGSYALIVTVFSIDKKRLAAENARMAEEKLRLQASEERYRLIAQDSEAIIVEINY
TEQAIKANAMYESVTGKKPDYAGFVGGEYVCAEDRTAFFELVSLACRTAKPAPRELRMRD
REGGYPWYSLLMSGIADANGNVARLVCKFTNIDAQKRRLALLELRAQTDPLTGLYNKTVT
QEIIERVLRDEAELVHALLIIDLDDLKGINDKCGHIEGDRAIAELAALIRRHFRATDVAG
RIGGDEFMVFLRNVRGAEQLRGAVAALSKRINGLSVGENDLCPVSVSIGAVLTEPGARAS
FCELYKKADAALYGVKREGKNGFAVYGGIDG
>A0A656ACC4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTDQTRTSPLVNRLLKMISLCALGYLLIILAIIIPRGIQSVEQQKQELEEKLALSLSNSA
AIALYVNNYDIASEVMDALLLHQEINAVKLASVDGIVFERTTIPSTYKEQNYWSDANRYR
LDSPVDGNLIGYLMIHEDHQVIRQQAINQILDQIAVVLIQFLVTFIALIWIVRRLVGKPL
TDLSQALSEVRPDHDRKVAVAAEDHHNEIGLVAKSINEFIDASHQALLRERELRQQIERW
ESYYRTIAEQDTLTGLKNRLGCEKFVLRKQRASTTMVLLLIDLDGFKQVNDTLGHAAGDE
VLREIAKRFYALAQTHFSDFVVGRLGGDEFAIYIPLDEFVAESIERFAAQLIESSSEPIG
LGQQSAQVGCSIGISHMNSLHIDLEKLLLQADKAMYWVKYRGKHGYHIYRMGEEXXXXXX
XXXXXXXXXXQDQFR
>A0A655X4X5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MADFIAKPTLEFTQSNIGEHAFSSQFLDGVFIYDPEGNLVWGKKYDAATGQSSSYEHLLP
DFSRILQQATRLSVDEISTSVRYMVVEDEPYLAATARVCDSDGKGCNKGFLIFIKKVRAQ
FANVVEQATGVDIEVLTCKNDAPLPQDEVDVSYIKQLDYSGNSSVLFKINHHIKHPPFIR
TEEILALLFFSLVMYLVNLWVVIALIKPITTASQVLQQFKTSGGKMPDASTFISSEMKEF
ATTINRIVGQLEDSQQVLRWQSEHDPLTRISNRRHLEKQLKSYLSDRPQAYLVLFLVDID
FFKRFNDSFGHLAGDEALCSVADVLQSVEFHGEKIVARFGGEEFCVVLASDCAFDAEQYA
QQMRSKIEQLAIANPVDALCQYLTVSIGGVYAISPKMESYLSLFHQADMALYHAKEHGRD
RYVVRNFV
>A0A655TH78|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIDIDHFKKINDQYGHITGDRILQAVASCLRKNVRDGDTIIRFGGEEFLLLFQAHSNKEA
WYMLDRLRQRVKDDHSLYGTTISIGFTFIDGSLPAAISRADTALYQAKEAGRNQVVADSE
KENDSAADLPIQC
>A0A655SMU6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MAADQQVFETRLSVIHEERAIAKSNGLVRIYRAVKHPILHRVTGEVIGLIGVSTDITDIV
ELREQLYQLANTDSLTQLCNRRKLWADFRAAFARAKRLRQPLSCISIDIDNFKLINDQFG
HDKGDEVLCFLAKLFQSVISDHHFCGRVGGEEFIIVLENTHVETAFHLAEQIRQRFAEHP
FFEQNEHIYLCAGVSSLHHGDHDIADIYRRSDQALYKAKRNGRNRCCIYRQSTE
>A0A655YY20|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MFETDAQSLFGKTDHDFFHDDQLSDILAADQQVFETRLSVIHEERAIAKSNGLVRIYRAV
KHPILHRVTGEVIGLIGVSTDITDIVELREQLYQLANTDSLTQLCNRRKLWADFRAAFAR
AKRLRQPLSCISIDIDNFKLINDQFGHDKGDEVLCFLAKLFQSVISDHHFCGRVGGEEFI
IVLENTHVETAFXXXXXXXXXXXXDPPTFCRASVL
>A0A840I3N2|diguanylate cyclase|EC 2.7.7.65|Parvularcula dongshanensis|TrEMBL
MTARVLVVDDLLPNVKLLEAKLRAEYFDVLTALSGEEAISIANEQQPDIILLDVMMPGMD
GFETCRNLKSNAATCHIPVVMVTALDQQADRLAGLNAGADDFLTKPVQDIALFARVRSLS
RLKQMTDELRHRHAQGAELGVVSPAALEELGDEERQIMVVTDDDLIDGLEGGVAELPAAC
NFTYVSDGRAALEALREGTPDVILVDLGMESYDPLRLCSAVRSFEGSRLAPILAIARSAD
TRRLVRALDIGVNDYMMRPVDPQEAAARIRTQLKRIRYVENLRASFNETLELAVTDQLTG
LYNRRYLATQLPRLMQEARSKGKPLSLMLLDIDHFKRVNDTLGHDVGDMVLKETAERLRL
SVRGVDLACRYGGEEFIFVMPDTDTTFAEIVAERLRASIAKDPVKLPDDGLGSSELGVTV
SIGVASMDPNDTIETPQSLIKAADEALYRAKDEGRNRVVLRAA
>A0A8B3KNP0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFWGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A7Z1CX84|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7Z8FJX4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDEVWGIGRRISKKLDAMGIKTVLDLAGTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A7W2VAQ6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-01064|TrEMBL
MMNDEIYYNKESIQEEWNKHLSQDDSHRSGIRFCRRIRLARVVGLAAMFFPIAGVLVTHF
LPGGWWLLLVGWAFVWPHLAWQLACRSSQPFCSEIVNLKVDAIIAGVWIGLMGLNALPTA
ALIMMIGMNMMGSGGFRLFIAGIIIILFSALVTLQLNGSMITLYSEPLEWWLTLPVLMLY
PMLFAWVSHRTAVRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEYEQCRRSHQTATI
LLIDIDHFKSINDTWGHDVGDEAIVAITRQLQLTLRSCDFIGRFGGDEFAVIMSGTPAES
AIAAMSRVHERLVNMPLPGAPSERIRISVGVAPWGPQFGHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A0K0Y514|diguanylate cyclase|EC 2.7.7.65|Octadecabacter temperatus|TrEMBL
MIELLFNAHIVVDPIALILALILIVSIVKRKKQSEWKSRLVMAGLFSFTLMLSMSNPIDL
GEGGIHDMRGLLIGVAVALLGPTVGLLTLATGLAMRLGIGGPGLAPGLVAMFAAFGGGLV
WRYKFYDSEHAVWIKSVILGCLISFHLVGLTLFPADLALHLFLVMGPYYIAGNIIGALVI
NYLLGGELSFLSEAQALEIDANTDHLTGLLNRRGLESALPNLKTKFAPKKGRALLYFDID
NFKTSNDKYGHAFGDDLLVGISERISMNLRRHDVFARMGGDEFAVILPEVDIEEARFVAE
RCRSVVGDEGFFYGEQKVPVTLSIGAVWLDEPSEMNAMILAADRAMYHAKVSGRNVVVFL
ENHSNSTLKRPIQNMQQVA
>D2A8D5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A174E018|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MQNDKRKQVNEIVSIVKLASLLLSGIILCKYFFTDDSLMFSFPGGIYSNLSLFLPLLLLL
LIYFIWTFSTINRIKNKHSILIGEIEKIIFILIFSIIIFISGSYESQYKFLYLFIIITTT
IQSGMKKGLIVAVISSIIILMMDLLMFQGSGVNWYFENDLILVGIFMLTAWPLGFYVKIE
GEHIKKLENMVNYDGLTNVYNHRYFQDKLKEKVEIGRKESKPVSMIFIDIDYFKHYNDLY
GHQKGDNILKELAAIVSNSVREEDIVARYGGEEFAVILDDTTEKEALEIAERIRANVEET
YFEGEENQPKGKITTSIGVSVFPDKAKDEVELIKSADDALYRAKFFNKNRVETYISILDD
LKKNIDDKDIELVTSIKTLISIINAKDRYTYSHVERVVIYSRLLADKLNLSDVDKSNLIY
GAYMHDIGKINIAKEILVKRMKLEKEEWEELKQHPENGVEIIKSVESLKDVIPLIKHHHE
RYDGKGYPDGLSGENIPYLARVLTVVDSFDAMTSNRPYNRRKSYEEGIEELRKCSGEQFD
PEIAKAFIEVIESNVAFL
>D2AFR5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A822W7X2|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MNNTWHQTATGNRPILSNLRLSRTLLNVIFIIALSLLLIINIISYNQVKNLIFASNWVSH
THEVIQTIDACLYDVVEIESRQRFYLIRGSSPQLMTDIDDMKSTLQLNLYKLEQLTRDNP
EQNKRTHRFIDLVKQRLNLLNQLVQLKGSGKLDTQEGYDLLNQSQDMSHQVKSLGQEIKS
VELVLLSERNTGAVRWADTSSFILISGGITSILFLTIAFILANIELSTRRKTELQNQNTQ
IRLKKIIESASDMIAAFDKDQRFITFNEAYQREFKRLFDKSISINMSLEEAFDDVPENKK
KLVQTWKESLQRDEETKNIEVNTEQEKTIYEMTSKLIQNGDNEIKGVVHSVRNITKRVQE
HTELQESYEKLANGMKELQKKNEQITLLVEMSDIMLACGSQEELSDVMAKYSQRLLQFSS
VYLFIMHPSKNYLEKAASWGNPQPHDLTFTPEQCWAIRLGRIHYAGSSRIELMCSHTMFA
EQPELSLLCVPLMAQNDIYGLLYLEVGLEFDENQQLLITAFAELTALALANVRLRENLRY
QSIRDPLTGLYNRRYLEDFLFKQLHQAERTKASFAILMLDLDHFKKINDTFGHDAGDLVL
KELGQILNSDIRLGDIAARYGGEEFVLLLYDIDAQAAKMKAENLRSAISNLQVKYGAQPV
GQITASIGISVYPDDAKSPAELIEAAAKALYQAKNKGRNKVILFSEISS
>A0A2H6GRF3|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin15|TrEMBL
MAKKCKECTHLEEKNELLQSKNTELAEDNADLNIQISRLTRENKRLKKIAMLDELTGLRN
MNFIRAEVKRIAALKERGYVMKRDTEKLKPEYVSIVFIDVDQLKHINDTFGHTIGDMVLK
HIADILRKNTRKGEVAVRFHGDEFAVLFLTNDRTEGKALYERIKKKVHAISCPIENKKID
VSTSTGYHCQVLTEKFNFDEIKEKADLKMYQNKRKKKPSD
>A0A5P9J5A3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MKFSRFGVIDLRQVILGFAVLCVMVTLGNQFIINYRVHGQQMVAHTLASNQAYASKLSDI
TEQFLNSLQMQLRYSAARLADNNTLKSQQQETLRLLEQTASFNSVVVVNEQGVITSTAPL
TLGVKGVRLESDSAKQSLRAQAPTIPQPFVSPASNLIVSPSHPIFSADEQYQGYIAGTIY
LHGDNILSRLLGQHFHNDKANIMVLSANGSVIYHSQHQRVGSKITPASPLWPAFTNAQMQ
SGSEGVGAMLVGYAPVRTANWVVLVGTERNQVVESVGNTIMNVLAKAAPVTVITLLVIWY
LANLISAPLRQLAQRVADSSKEYDDVPTWFFEAKTLRNALRTYSNEQHQRINDLNKASLT
DPLTGIGNRRYMEVFIQSMVADEQAFAVITLDIDHFKRVNDNYGHDVGDDVIQGLGQLLQ
SSCREYDGVCRSGGEEFLLILPGIGKDIALELAERLRVTIQAHDFTPVPQVTVSLGVSLW
QPGCSVDAVLKAADNALYRAKQRGRNRCEVELLG
>A0A653KMH2|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MKNNKQANFSLASMPQDINVTQRTWYQNAMEKPGTSIWSSPYIDAVQKTPVVTLSHAVLN
NQGNFLGVIGIDLNLKVFSARIGRLLESGDKVGYMLYDRGSRLVIAHSDPLENGMPLVTS
WTDELKGRNGSFMSMDGELIAYHALHNNPSWLVITVFPFTNSFLIGEMLPTTLISLILSL
SIFTLVAIIFRQRLEHTISTLVQVVRQLRVTPAGQQIVIPKLAGIEELEDEIVMISDKMQ
AETEKSLRDALTGLYNRRHLEEILATLHRDNHQYILAIIDIDNFKRINDTYGHPIGDAVL
KRTAQLGNQLLEEHATLCRFGGEEFVAIFEQTDIASAQQLMELWRASMGQQDWREPGLSV
SFSGGIAESLDTPPDSVMARADAALYQAKQTGKNRLQRA
>A0A2C9NYE1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTMLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTSEQQTAN
TLNDRERALLAREIEKDTLGGLRLGMHYVSWGRLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A447JE11|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Daytona|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4P7J2Z2|diguanylate cyclase|EC 2.7.7.65|Citrobacter tructae|TrEMBL
MFPNTMNDENFYQKQVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAIGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPLHSEFTNLKADAILAGMWIGLMGANL
LPSTAMLMIICINLMGAGGIRLFLAGLVLTVVSCLVTLQLTDIPVALSSTQVSVLLSLPV
LVLYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PAASAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A101D0K2|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. 54_146|TrEMBL
MRYKDKHQLAAEWQTLLERTPRPLRQAVEALVEQHSSDFAGHFYTVMLEDPHASLFLSNE
QVQKRLNPSMQRWLTAMFAVEHADFEALVEQQEKVGQVHARLDIPVNLVLNGSRQLKQAI
YKQINATFKNPLSPGDASVYVSDHIDMAMEIMSHAYSVANDRNARTEEAYKLFSLTQSIG
NEREKQRSALLNWENTLMFAIAAQQGTDGLPKLATSEFGLWYFHKACHAFEGAPEIATIS
RHIQQVDNEWLKALSNDDATQRLSALSDIRDAVRTIVMLLDDVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIEMARHSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDCVFRMGGEEFLIVLVNTDQDGSRLFAERLRQAVAKEPMLASADTLLNITVSIGVT
LHDGHPDYQRSLQRADQALYEAKRSGRNRVVVQ
>A0A1H8NB21|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MTTAAAPTRAQVPDVAGQITFAMRSMGVAPIPRNYELFYEAYIGSNPALTRDLAALGSQA
TQEELDALGAQYFAHSPARVFDDAHGRIAAELETLLRVLRQEQISLESYNKLLGETYKRI
SSKNHTSVELIENALTLLTEATGDTMAHGERTVENVVQRSQEMDQVRKELDEYKRIANTD
SLTRLSNRRAFDDRLSAVFNNPAMRPVTALVLADIDNFKKINDTYGHPVGDKILATVASV
IRANVRRDVFVARTGGEEFALIIEGNTSEEVMGTAERIRRTLETTPFTNSRTRVNYGPVT
VSVGACMASYAEDAGELYHKADVALYGAKNSGRNCSVLFEDGMQKDFTKSWLIYKA
>A0A8H9YVL8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MQRDTFVIKKNLLERLRHHPGQIVNACFLVVLIFSTILTWREVVVLEDAYISSQQNHLQN
VANSLDRQLQYSVNKLLFFRQSMGDALQTPLALRVLHDAVLSFNHLRDKPFWQLDIEQRR
ALPINGVSDGMVERTTLLTRDDQRLGGELSAALEVGYLLRLAVSRANNKEKRITYVSRAG
FFVSTEPAALNNSIVSRYYTLVTRPWFTHQNDRDNRERAVRWFMAPASALQNERLITASV
PVYQDNYWYGVLAMDFTLPTMTQLLMDAVDQRKDGEYQLYDNRFNLIATSEENADSVIQF
DAQELAQIAQAVENDTQGGLRLSTRFISWERLEHFDGVVLRVHSLKDGVRGEFGSISIAL
ASLWALFTATLLISWLVIRRMVSNMFTLQNSLQWQAWHDPLTRLNNRRALFDRAQALAEE
CRQQQLPFSVIQLDLDHFKSINDRFGHQAGDKVLSHTARLITHALRSSDVAGRVGGEEFC
VVLPGATAEQAAGVAERIRVSINRKEILVKKGTTARVSASLGVSSTEENANFDFEQLQSI
ADARLYLAKQQGRNQIVCRGPDKK
>A0A200NX44|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A837KG89|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNDESKKYISVIFKEWLPLYDSLTPAVKEVLKNIAEEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLALWVKEILTSDKAQLPALAERQYQIGSIHARIGIPAEAVLRGARQIK
AGLIEYIRSHVNDRQIAVDAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPMEYGKQQAALSGWENTAIFNIVSENKAHTNATLLSESEFGLWFRHKCVRYFNKNSQM
DEIAALISQVDDLLIGWRASASAMDYKNTQNLIQGIHIHCQQIGSQLGVIFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKGINDNWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGVSEAFTILDRLRKKISQLAFNVGGDTQIPI
TASIGYAVHSGHPDYNLLLRDADNALYAAKREGRNCVKMHKGRV
>A0A7Z8GL56|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRCLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A2S4MW79|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A212L6H9|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfovibrio sp|TrEMBL
MAPDEKKDACIGINAFLSSGIVVLGLIFSASFFYYMNMARDISVASTRIYGAYLPLTEAL
DQVDRQKQDLWRLLGEVALAESGAQSRQDVQAAIAQLRKAPPPGAIVQRQHWEGALSALE
RLAFLHAQAHDLEAALHSPPVAQNAGLRHDGDHDDQDATGNAASYAAGRLVAVRLAMDAA
LTDFTSALSNIEARNPLADEMHGQLRRTAALAHDFENRLLLGFLFLGAGMTSLYAILRLQ
LARPLRGIMAYLDQLGTGVKKLFLPRSRIVEIRNIASALDNLSTYLSKATIQSNKLVSEH
DRFQKMSLVDGLTGVRNRRSFDDSLRALWRFAQERQQPLALIMLDVDKFKIYNDNYGHQA
GDECLKRVAAAMTRAARSTDVCARYGGEEFALLLPGADTHTARAVALRIHNEIEREQLPH
PASPVNGFVTVSLGVASLVPGKDAASDGKLLVRNADAALYDAKSAGRNRTHTYGEEMACT
PTAQPA
>A0A6N3HNM1|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MMNDETYYNKKRIREEWSLTLSQDDPYHAGIQFARRVRLARAVGLAAMFFPVAGMLVIHF
LPGGWWLILVGWSFVWPHFAWQLSCRAASPHQQEIFNLKMDAIIAGLWIGVMGLYALPTA
ALVMMVGMNMMGSGGCRLFLVGITLTLLTALVTLPLVGKVTVFNPDPLEWGLTLPVLMLY
PMLFAWLSHRTAIRLAEHKRRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRSHCNATI
LLIDIDHFKNINDTWGHDVGDKAIVALTRQLQMSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHERLETLSLPCAPKEPLRISVGVAPWGPQFRHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A1V4VV01|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MKDSDKTKKQLINELNEMKRKVAGLKTPQQVEEKLTWLASMVEFSNDAIVGMSLEGIIFS
WNSGAERIYGYKADEVIGRPVFILAPSYGEITSNLERIKLGERVDYYETVRVRKDFRQIQ
VSLTISPIRDASGKVIGASTIARDITGQKLIEEKLRTSEARFRAVFEGTSVGITLINREG
RLVESNPALQEMLGYNGQELANMVFAELIYPDDKVNFIEMFNDLWAGRQDSYQMEKRYAR
KVAGWFG
>A0A1C3JI01|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MLTQSRRSRLLFIGPMRYFAYKPIDYYVFLHFTLLNIPNINVAINFGCSGASFMNQASES
EIVIRRLYQITNDYRKGFDIQIAQLLIMGLERFNLDIGILSKVEGNTYLVEHSVTPEGVE
LNSGDIFDYRSTYCEITCKSIGPICIEHCGKHDKYAKHPAYQSFGLESYIGVPIFVNDEL
YGTLNFSSPAPYHREFKEFDVDVMRLMASWIEVELVRRQQERKLKELNEKLEYQALYDPL
THLPNRRCLFKTLNAEVEQLKGSLGKGTLAVVDIDFFKQVNDTYGHQMGDVVLKKVANVL
SNNTQEGEFVARFGGEEFILWYPNKTPSCVEDKFMTLLQEMKKITLDRKPVTISIGACHF
ELSTGDTKGERMSALDKLIKVADECLYIAKQNGRDQFISRPYHQERSGI
>A0A011P823|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MLELLVAETRIADLESALCRAQAAALTDTLTGALNRRGFDQAHEREAARSRRNARPLALA
LIDLDDFKRLNDTLGHQAGDQALIHLVRTLRSALRPSDVLGRFGGEEFVLMLPDTELDEA
VTALTRFQRQLADCRVTGNGVALTFSAGVVVQAPGESLAESIERADTATYAAKRAGKNRV
FSG
>A0A6J7ZGV6|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MSSGHILAYQLVSEQTLNQIMRLTQQIHQQLELGEVLDVTVKGIREILGCDRAVVYRFLA
DGDGVIVEESVSPEWMPILGKLIHDPCFQAEWVDLYRRGEISLIEDVKTKPLQACYKQLL
QRLQIRANLVVPILITRSPSSQISPTLPDLWGLLIVHQCQSSRQWKTLDIQFLQQIAMQL
GIAIQYREANQYPWQLYQQKSQRILLPIQEINIAQDCQYCHLGDEYLTKKSNNAISITEL
NGLDRLQTPIWIFDIENLQMWWANHAALHLWNSTNREELIQRNFQDISEATRIHLNAYLQ
QFKHQKTVTETWTFYPQGQPMSVRCTCSGITIETGRIAMLVEGITKVANQSSPETLRAIE
VLNHTTVMISLYTLDGVPLMQNPSALECYGDTLYPNLNHDNAFVRHFVDPQIGETAIVTA
QSGAVFSIETQVYTLNGIRWHGLDVRCTRDPVTGNAMLLVNEKDITEQQTALIEHLHTEQ
ELRWKEALLRSMTDTSNLAFFVVDNRTDNIIYFNHRFCKIWGVEHLEIQMLAGVLKNNDI
IPDCITLIADVPAFAESCKPLQSEENRAVIEDKIAFSDGRTIRRFSSQIRDQSDHYFGRL
YIFEDISDRQQVEINLRESEERYRSVIAAMAEGIVLQQADGQITACNQSAEDILGLTADQ
MMGLTSIDPRWRAIQEDGSNFPGENHPTMVTLKTGKPQFNVIMGVYKPDGNLTWISINSQ
PLFHPNPPEPYAVVASFTNITARKQVEETLKQQVEGERIIYTITQRIRQSLDLDEILQTT
VAEVRQFLQTDRVMIYRFNSDWSGLVVKESVSPGTKAILKMEITDSYFVENHGQYYQQNT
IKATPDIYTAGLTPCHFELLEKLQVRAKLVVPIILQTQGLWGILIAHDCTKPREWQNLEI
ELMQQLAIQLAIAIHQSELHQQLQLANQQLQNLAMVDQLTQIANRRCFDEILHQEWHRLV
REKRPLSLLLCDIDYFKQYNDTYGHSQGDICLQQVAQALQQGVQRSIDLVARYGGEEFVV
ILPHTDQEGALEVAQKIQDVLEQFNLPHRSSNVADRVTMSIGICSLIPTVERFPLDLINA
ADHALYQAKTLGRNRTVGSVL
>F8JB08|diguanylate cyclase|EC 2.7.7.65|Hyphomicrobium sp. (strain MC1)|TrEMBL
MRGSAAKGVTAFKPSERTQTAAAKKAARKAKTAAAPPSLSGHVKALASALDPFGCVSITD
NEGRIIHVNDAFVRISRYARDALLGQNHSILSSGHHSRAFWSAAYEVLNRGETWHSRIQN
RAKDGTLYWVDATIRPLKGRSGRIIGFVSLQAETAAPVETHVARPNNDVLLQAVAESFPG
GLTVFDRDLHMVLINERQKQLLEYPDDLFKRGLPTLEDLYRFNAERGEYGPGETEKQIRS
RFDLTTKGEAQAFERRRPNGTCLEVRSTPLTDGGFIVSHFDITERKRDQETIGRLEHQDA
LTGLPNRTLFQERVRSALAQAKGGWALAIHCLDLDRFKSINDTLGHHVGDALLFAVGERL
KSEVRDTDTVARISGDEFAIIQMAPQSIEEVESLAKRILSAFSEPFELGDNTLTVGTSIG
IAVGPSDGNDAEKLLTNADMALYRTKSVRRGSFGFFEHSMHERLQKRHQIIMGLHEAIAN
SKFELHYQPIVNVKTRRIVGCEALIRWSHPVRGIIPASEFIPIAEECGLIGQIGDWVLKR
ACAEASLWPDDIWVAVNISPAQFREPDLVEKVTNAAKNIPLSRVILEITETLLMKDRDAA
SATLETLRKMGVRFSIDDFGTGFSSLSYLQDFPFDKIKIDRSFVSAVANIKRSATLRRSI
IQLGYNLGMTSVAEGVETEQQLERLRAEGCVEAQGFLFSRAVPAAKLRTLFANPL
>A0A1A8TSU0|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MKASELIGLSDVLELMLDAVCVVDRFGHFVFVSAAFENMFGYSPSEVIGQSMERMVFPED
KLKTAKVVETLLNGEVQPRFENRWLHKDGRIVHVLWSARWSEEHQVRIAVAHDITERKII
ESRLVYMAAHDQLTGLPNRSFFLERLEGGLLRVNQNESDPSPVVLFVDIDGFKQVNDNYG
HGVGDKLLQLIAQRLQH
>A0A4P7TLG8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENGEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A8G0CW50|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLEQYQQLQRTDKSIELRLARLKDNGASREELALLHDGLQIAAELQD
EQQAALTHVAHGDAPAAIAVLYGNAYETELERMQTQIDRFRQMLENRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFVLKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAYAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGTAFRYGGEEFLVLLPGLDEAGAHQCASEIYTQVHAMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A7Z7RJQ4|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MSFVFTPLAALSGLAALLAAAISIIAWSRRQFAGVRWLALLMASVAFWAAGAMCELSVTS
IAAKLFWSKVEYLGTLSTPVLFLLLALDYNHISLRRRGLALLFAIPAVCLLLAASNERHH
LVWTSFQPSPSGHNLLIYGHGPAFWLGVAGYSYLMMLLGSLLLIRALHYFPAHFRGQSLT
LMLSAIAPWFGNILYLTGAFPLQGLDPTPHSFAFTGLIFAIDLLYLRQLHLVPVARARAF
EAMGDGVVVVDHQLRILDINPSGIRMLGGAPADWPGQPLPAPWLEASMLETGAHLELTTP
DGGRILDIRAYEIEPFHKPARTRMLVMRDITQRRQAEDALREANLQLTDRLAQIETLQAA
LREQTLRDPLTHLFNRRYLDETFERERERAEREAKPIAVAMMDLDDFKRINDLHGHQVGD
RVLQALARLLQQQSRAADIVCRLGGEEFMVVLPGSDAEQAQQRVEAWRRDFHHLEHAGEH
PFRASFSCGIAALPGNGRALDELYRRADQALYQAKAAGKNCSVRAASGQ
>A0A014MIZ8|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica DA1877|TrEMBL
MPSFYAKQWRRLLSSFSPQIRCLVAEMAQAHSQALAEHFYSAMLEDEAAAGLLSHEQVHA
RLMGSMRQWIAQVLSAQPEDDLEPLVQHQVKIGEIHARVDVPVHLVLRGARRLKDGWHHL
LAQHHPEQQTLASQMVAAVIDHAMEAMSQGYAVSRDSNSRTKEAYRLFSVTQNLTTVREQ
RRAELLAWENQCLYLHALGAESQPLSNLASSNFGLWFRHKGADMFQGAPAAQSILDAIER
IDQELLPALMRAKGGEVAQPLLQLHEQVRHMAMNLEALFTQNSELDAGRDVLTQLLNRKF
LPVVLSKEVSYARKSAAAFSVLTIDIDFFKQINDQHGHEGGDMVLQQMAALLSHNIRGGD
YLFRLGGEEFLMVLVDTGSEGAQRVAEKLRKQVEQARFQLPRNQTQGVTISLGVATFDGH
PDYQRILRQSDAALYRAKTAGRNRVQVAELEG
>A0A1V5DCM3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MGTEKRIFIIDDEKDLLFILKEYFEAHGIEAVTYEAPPDLGVEVREKKPGAVLVDIFIPN
SSGFDILNNIRKIDSNLPVIMMTGQPDDEKRLESLRNGAYALLAKPFRSFEEVYHIVNNA
ANHYGEIQRTVELTEEIRKRHEHERLNLLELDFLKKLQLMIGETEDSSFVIKNSFALLKN
FLDFEVFAVRMVQGEDINIQIYPNVGQDARLMECVTATLVGKVPERSRAEKQTGATTGGD
GEPAYSYMTVDMSSRDTVYGYAGLYRELPFNESEEAIFNRFCSNIALTLEKIRLFNEIKA
LSIHDGLTGIYNHAFIVRALEDEIERSKRYGSALSVALFDIDDFKSVNDTYGHLAGDAVL
RRLAELMKSSLRTIDIVGRYGGEEFLAILPETDGANGYTVAERFRDTVEKEYFVYGGERI
MMTISGGVGRYAYGMDVNKLIKVADDNLFRAKREGKNRIVL
>A0A080MCS1|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MNDDELIRTLAEDRVIPMAGLLSLLMPASAGVGFSLKGLDGRYRLVNREMERLLGQGPAC
LVGRSESDVLPTHLLAQLAHCDQRILDGASASYEEVEMPVDGRISRCRWINLSVFGTDHK
LQSIASIVQETFPSPEISSMQQTLDRLRQANQELQRTVGELEQVASTDKLTGAWNRRRLE
ECVRSEMDRLNRYEQPLSLLLVDIDHFKAINDQHGHGVGDQILQTMTSMLQSRLRGTDAL
ARWGGEEFVVICPNTGRSTAALLAERVRVQIASADFPLIGQLTVSIGAAECNPGDTWEEW
FQRADEALYRAKTGGRNQVQLAPAAVRPPDTQGYVVANFVQLVWQSAYECGNELVDRGHR
QLFADANELLAAILGQYEARRLDLIVETLTTDVVRHFADEESVIHAAGYPGAAEHAVLHR
ELVAQARRLLDDYRAGKQGVGDLFQFLAYDVVTRHMLGEDRKFFPYLRTQVAAPVRNREA
PSP
>A0A142MFT4|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MTARILVVDSIFANVRLLEVRLLAEYFDVLTASNEFDVIETCENGKIDVVLLDVKMPDMD
AFVVCKRLKSGPATSHISVVMITAIDEFTDRVRGLEAGADDFLTKPINDLQLMTRVKSLV
RLKLLTDELRLRASTTHDIGIEDLLNGRSVFDGANPKTLLVDERKSSFEHIQKILHGEAE
LDIATDPHTGFFRAAETPYECVLISTAFADVDPLRLCSQLRSLDRTRFLPIILLADIGEE
GRIIRGLELGINDYLTRPIDQQELTARLRTQVRRKRYNDQLRASVTQTIEMAVIDPVTGL
RNRRYFQFDQAVARRRPLSILITDVDLLKLVNDTYGHDAGSDVLRECARRLRKNVRGIDL
ACIYGGDEFVVVMPDANCAVAEKVAERIRVEIAQMPFSVGYDGKAIDVTVSIGVSSIFVG
ADTVAGLIKRADIALYEAKTGGRNRVIVHLD
>A0A1J5T952|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKIGKHISLLWRGSIRRQLILGFALASLALMLGFGYLTLEQQREALYRSSEERASSLAHA
LAISGTSWAVANDLMGLQEVVQGFARTQDLQRAYFVNTHGEVLASTNPDEVGFFLTDKVS
RDMLASSARDQSVLVNQQNLIVVAHPVMAEGRLLGWVRVEMSRDAVNANLSALTRAWAEF
ILIAVLAVSLIAMVLARRLTRGLDHLMQVAAAVEQGLGKRRSDIGRLDEIGVLARHLDSM
LDALDQQKKAIHESEARYRFLADNISDVIWIANLQTKTWMYMSPSVEKLLGYTAEEVMEM
PLGQLLSATSQADVREWIAERSQAFLNGSEGDHVYTDEVEQYCRNGDKLWTEVTTHFATS
DAGELILLGVTRNITERKRAEEQIRNLAFYDALTQLPNRRLLQDRFNQVLSACRRNNRFA
ALMFIDLDNFKPLNDEHGHDVGDILLVEVAHRIVSCVREVDTVSRFGGDEFIVMLSELDA
DRAISMTQASVVAEKIRQSLGEVYRLNVAQKDGRPPRVIEHRCTASIGVVLFSNHGATQE
DLIKLADAAMYQAKSAGRNQVYFADT
>A0A5I4KMA9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Aberdeen|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0M6Y5S5|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MRYEPVGHGSPPLQKAKGEAQAVEIRRLSKPFWITVIISAVSLMAFVSFLSWTLDRNSIR
SSEHIFTAMLGDRSDHLADITLEYGYWNDAVENLVESFDMTWIRETFVDYMQEELQIDGI
HLLDGNNQPKVHVVEGKVANTDLRVRYGPSMSVLIADARNTPQDEAPVPATGLVGNLETL
YLASAVLLTSYTDDSDTSTDHVLVFARPINASVLADMAEKYHLPGLGLAQIPPAFWQAGY
DIETVDRRHLGFFVWNPELAGFRMLPLLALGVLAVYLGMFLSARMFFHRATDTVRALAEA
KHQADKVKELLANQVRSDPLTGLGNRRLLDEKLALLQDVKPLADGHALLYVDLDRFKEIN
DTYGHETGDLVLLHVAEALTGLVNADDTVVRLGGDEFVIVFGRARRERVLSASRAIVEQL
SRPVNLDGATYTFGASVGVAFSHKPSELLRQADVALYSAKRRGRAQVAVYSSDLLDFRHV
PIQSAAQPG
>A0A1R4H2T9|diguanylate cyclase|EC 2.7.7.65|Crenothrix polyspora|TrEMBL
MTEQNIFLKNSGQLVVAAVLFYATGWLAMLVAPPPAYIGIIWPPAGIGLAAVLLWGYRVL
PGIFLATILLYLNVFDLAALWDSPQKLMALCSVCACAVLRAWLGTILVKRFAQFPYTLVT
LRTIGLFFVLAGPVAAFVPAALTVFALHVSGIIMSSDIYSLFLKTWLADCTGVVIFIPLL
FIVFERSQRIWQDRIITLGLPLVLYFLVTMALSLYFQQKNMQYLLLDGALLPVCISVVLL
ALTGYEESIKIAVDERTEELTQSNRKLRSRDRQFNKLVQTQSVIVWRAHPVSFRFVYVND
EAKTILGYPISLWKNEPDFWWEHIHDDDKDRVQAFCAEERKPRDVDLEYRMITADGDVVW
LRDIFTKVVSNGVVSELYGLMIDITKQKLAEEEFRVAAITFESQQGIMITDSQSKIIRVN
KAFTDITGFTLQEVIGQEPKLLKSGRHDQTFYKNFWQQLMTVGMFEGEVWNRRKNGEIYP
EWQIVTAVENNGEVTHYVSVFSDITQKKEAEDKIHSLAFYDALTGLPNRRLLLDRFEQEI
AIARRHKQFGAVIFLDLDHFKLLNDSQGHLVGDELLIQVANRLSSVLREEDTPARLGGDE
FVVLLHANSENLSEVSDHARTVAEKIRKQLNTPFLLHHYQHQISTSIGITLFPEGDESPD
MILQQADTAMYRSKAGGRNAISFFQPSMQEAADQRLKLEQYLRTAIDKEGFMLFFQPQVD
RSGVMLGAEVLIRWEQVEQGIVSPADFISVAEESSLILDIGLWVLKKTCQQIKEWLVMGI
HVPRMSVNVSSRQFRQPDFVEQIKAAISDSQIPPALLGIELTESVMIVDIDDTVTKMKAL
KKLGVSIAIDDFGTGYSSLAYLKRLPLDVLKIDRGFVRDILTDTNDAVIVETIISMARHL
KLRVIAEGVETEDQFDVLKKQGCLMFQGYHFSRPLSAVRFAEKYLANL
>A0A1J5Q4B1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDTSTAAPAPAVRATDPLHRDRVLIGLALVIAGSALVYGLDLGTRSAQVVACWVLLLGLH
IGLAVVARQVSRVPGTARTTRWIWAAIAIAGGTYAVGDTTQLFTIAISPMNLTVAIGGTV
QSFSVLLGTSVPILVALLVTAPIGGGSRRETASFWLDVGIVMAAAATFGGYVYVPDGSKP
AEILLSLLVGPGLFLVGVFAVVKLFLSSQPPFSRLAGLVLGAAAALEGAAQAATALLVDA
RGLSWLLGLTVVASAVLMGSARIQYRQANLATGVLGPRPPRRYSTLPYAAIAATYVLLVW
VLVQDGLTGHTWIVITGAIASTALVLGRQLVAFTDNSRLLDELDAKVQELHQLLRERDDL
ATRLRHEALHDPLTGLANRSMFNRRLQDVIREGDTPARPLTLMIVDLDDFKQVNDEYGHA
SGDQVLVAVARRLRSCVRDVDLVARLGGDEFALLLEDLPDDADQVARRIVDVIAQPVTFA
GGSGGSGGTGGTVTVSASVGVVVADLDRRTAEQLLHAADTTMYSAKRSGKGAYRVSVVAG
>A0A1J5STQ3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTPSLLTNAELYRCAFEGMCDPILLLKDGRFVDCNAATLKMLGGITKSQLIDRTPGDISP
AYQPDGRTSADKAEATIAIAMREGFHRFEWMHARADGSEFLVEISLTPITVGSEVVLLTL
WRDITERKQAERFEQFRSHVLELLAGDQPLPVILEAIVRGVEQLDSAMLCTILLLDKDGK
RLKTGAAPSLPDFYNRAIESVEIGVGVGSCGTAAFTGERVIVDDIATHAYWAPFTELAAQ
AKLGACWSQPIRSSTGQVLGTFAIYHHEAHRPAESDLHLIEQTAHLASIAIERSVAAEKL
RDSEAHYRLLTEDALDVIWKTDSELRMTYISPADERLRGYRADEVVGHHVFELFTDEGIA
TAKEIMRQRKAIGSPAAQADFINFEAQHRCKDGRTIWGEIFSTAVFDEQGAITGYHGITR
EISKRKQMEEQVRQLAFHDSLTNLPNRRLLYDRLKQSMAASKRSGCHNAVMFLDLDNFKP
LNDAHGHEAGDLLLIIAADRLKRSVREIDTVARFGGDEFVVVLNELDADRAASTALAGNV
AEKIRAALSAPYLLTISKDGKTDIVVEHRCTVSIGVVVFINHEVNQDDILKWADATMYLA
KEQGRNMICFFEGEI
>A0A1J5QTS3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDQKPKKKPWIVRTHHRMRTISFAMLFVAIGLHIRDQAYGAAAWLLLTLQFLVYPHLQYW
RARRARNPVATELNNLLIDSALLGVWIAALGFPLWIAFSAIIGTLFNNAGNRGQRGIVAA
ALALSGGALAWIALAGLTLAPDTGWPVTLFCIFGLTVYLLTMGNIGFRRNRELRQTRERL
QQGERVLLRANEDLKSRLREIDQLQEQLREQANRDALTGLYNRRYLDNTLERELARCKRE
GLPLALIMIDIDQFKRINDTYGHQAGDEMLRRLGAILGSMARAEDVACRYGGEEFLMLLP
KMPLGVALERAEKLRTDFCTLTVPFGEFRLKTTLSIGIAIYPGHGKSADALIQCADRAMY
RAKHEGRNRVEVEAVGDEMQTAGSDSGALVKVIWKDRFLSGHRVIDAQHRALFGDANELL
SAILAGRPAADVDAMIDALMRDVVRHFQDEEAILGAAAYAGTAAHAALHRALADRAATLV
ERFRAGAIGLGALFEFLAHDLIAKHMLIEDRLFFPSLRDPH
>A0A1J5TAU3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLKHSKIEDFAEDWRQVQQQVSGATRKLISDTVNRYAADLATRFYDHMLADKEANPFISH
DIVSQRLHTSMQGWLRELFTLQQQDPKEIYKYQCHVGVVHARIQMPISLVLRGSRLLKQA
ITEYLVETELGRMELVQATRFVSEVMELSMSAMTDSYIINVGKSVRTDESYRMFALGQNM
LAERERQRAALSEWAQHILLHLLGDEGAGVPEMRHSEFGLWLQHKASIIFHEAPELARIR
GCVEKLERTLLPSLIEKRRNGGDAREAMRLIEADIGEVKFLLTGLFDRFIEVESGRDSLT
RLLNRRYLPTILMRELALARNSDVPFAILLLDIDHFKNINDTHGHDSGDMVLQQASDLVT
SSVRVGDFIFRYGGEELLVVLVEISKEQALQVAETIRERFAAEPMRVGDGKLMDVTVSIG
VAAYNGHPDYERIVKDADDALYRAKNNGRNRCEVAG
>A0A1J5RLL7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MIALFRQAIRDPLTGVFSRRSGEELLERQFQIALRSWTPLSIAFLDFDHFKEINDRYSHD
AGDKALIAAAAAMTKSLRLSNILVRWGGEEFVLIMPDTDPAEAGQALTRLREAGLGERPD
GSRLTASIGFAERSQDRCGDWRRLVEAADRRMYLAKQGGRDRVVFTDAA
>A0A1J5S411|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNELRVLFAATSVGNMAKVIEHLRAGDCNVQYEQASDEVTLDGHLHQNWDVLLLGVSAEL
TIESVVHALRCRTLDIPLIVLNDAMEPLPLAEVMRLGAQDCVALDQMERLLPSIQREMVS
AILRSNLREQVVADYLMQEIDQLILLGYDMRSLNERICRRMAELFDFKLVWIGARMLDGR
VEPLASAGESAYLEGIEVRWDDTPQGQGITGRSIRNNKAESMSSDSPRFEPWRERVERYG
MRSVLAMPLGVKNEVAGALVMYSAHENTFDKLTISRLSAFAGRVTVAMLGAQEQQELRLM
QAAMSNAANAMFITRCDGVIEWLNEALSRYSGYTSAEITGSNPRIFNSGQHQQSFWSEMW
TTIQNGKHWRGEVVNRTKTGELYTVAQSISPLYDGKGELTHFLAVQQDISEKKRLEEEIH
YLAYHDPLTHLPNRMLFRDRVQQAIVQAQRAHARLAVMFIDLDGFKAVNDMHGHNNGDCL
LELVAERIRLCVRAGDTVARLGGDEFTVLLRDVKDRESIEGVAKKLLDIAAQPYMLDSEI
PATVSFSIGTSIYPEDGESFDALLSRADQAMYKAKQGGKNRHLFCGDRT
>A0A1J5QCX5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLLEQARSARKEREIVKLGEGLKSFWFTLEMSSDAQYRMHEELLHLLRLLVDNMSELVVD
DQWLSGQTAIIRDIISKPMDIEVLYNAESSLKELIFKQGKLKHGLVEARDTLKQMASTFI
TRLVEMSESTGEYHQRIEKYQRQLSSTEDIAELNVILDNLMGDTRAMQLDALRSHEGLKE
TKIKVLEAEQRILALTAELDHASEMAHEDYLTGALNRRGMDEALEREFSRADRFGTEVCL
AMMDIDHFKRLNDTLGHDAGDVALAHLARVTKDTLRPTDVLARFGGEEFIIILPETGRDE
AIAVMTRVQRELTRQFFLHNNERVLMTFSAGVAQRQSGEAAEVVMKRADVALYQAKQAGR
NRVFAAD
>A0A1J5SIH9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKYEHDRHASEEILRLLIQKMAEHPAAFTPQNYAVWYEYVTGINPALSETITRQLDNGER
LDDATIEGLYLKYVSECNMDVEWALREDIRQLLRKLAESTKETDDQAHRFDTSLHAYGDT
LKQNPDPARLVDLIKNMADDTSRMIGSMQDLQSELAASKQKVDKLHLELQSARGEALIDP
LTGILNRRGFENSAKIALSNQAALGSGICLLMVDIDHFKTINDTYGHLFGDKVIRAVANT
LKSKVRGQDSVGRMGGEEFALLLAETDISGALTVAENMRKTVEGCQIHRVDAQEKIGGIT
ISIGVAECTSGDSLLDLLGHADKALYVSKKQGRNRTTVYADIKAP
>A0A1C6I022|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKKVLVPLIVFLLGICFVGFIVYKTDIHEKEQRHTTAQLNASTYGERIKNEITHGIGIT
DTLKQVLISENGKFNQFDTIAKNLMSDSIESVQLAPDGVVTDIYPISGNEAGKIDLIHDK
NRGKISRYARDNHTIITQGPFKLKQSGYGVAVRNPVYLKDENGQEYFWGFTIVILHVPDI
FSDTLNALSNFGYEYRLSKTDAPWSDTYKVVYQSDRQLTHPVSYKFTIGEENWRFEVTPK
SGWKNNTLIAEVGVVFTAIVILLSVLTRVWLVSKEHKNKFKILAHTDSLTDIYNRYGFDE
LAVKMIDKNPKSHFVAALLDIDDFKSINDIYGHAYGDNALKSLADNMKAFFPPDTLLGRN
GGDEFCILLPNYTCEEAEELLQQFTRLPKTFSYMGKEYPFHISLGYAEYPTFASNRSQLM
RCADTALYEIKLHGKNGCMAYRAGLSSGVRKQLGFALKDISEHLPGAFIIYRADKEDDEL
FYANHEFLHMTGYKNMDELFRLTKKSFRNLIREDEQKQIESSIWEQIDNGNENDYIHFHL
RKADGTYLSVLDHGRIVESQQYGRVFYVLFMDWEDMHIHYSDKFSE
>A0A6N3HX17|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MNDSGTVKKGERVSGQKFVRRMFLMRVLGTFLCFFPILSVLLELQRPLWLMLMLAANAFI
WPAIAFLRARNAATPLTHEHHNLVIDAAAGGFWIAMMAVNPLPSVVIATILLSDRLAAGG
YELLRKAGMVMLGTFAAAWLAEGLSVDITVTQRTLFATLPLIAIYTLALSVLTNGIAVKL
KVKSRELERIAMMDPLLDIANRRLLEKRILSELNHLHDAARRSSLMFIDIDNFKEVNDRF
GHEAGDALLVKVSHILHAATRKSDTPARLGGDEFVILLPDTTPQEALEVAKRIVDAASTL
NVAPMKTFRCTLSIGIAEATPGMRTVTDWLKAADDALYKAKRRGKNQIYAR
>A0A379ZX78|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MTYIASISTLYSDACITYATLSISYFLLSKNAPFSYQSALWKRVVFGLLAGVAVLYLSQD
RLELTDKVHYSFAMIPMILVTFFGGGVSGLVSFLFAMALTGGFTVDNLFIASIVAPLLLS
RVWLKKSHRVFYLTIGIIALYRIAVVWLLVDMSGLWPDVLLYQAVSALCLAICYHALNFK
ERHIYAYFAMRARATTDSLTHINNRASVDYQLMLQRAERRPCGLMILDLDNFKSINDTYG
HPAGDVLLASVGRLLQNSVRNEDFVGRYGGEEFMVITASYDPQVIGGVAERIRSAVESST
FLLNAHDEAHITLSIGVSLYLPGMTLDKAIAMTDEALYEAKRGGKNRVVTSRVMQLAPLG
AGFPRE
>A0A2H6B843|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MRQARETQLRRLRRLHELTVELSAAIDPEAVARCLARAASDGLRASACGVYIARGALLEL
VDARVSAAGRVPQQLPVRDAAASLAADVALLELRDGDQLLGAVALSPAPEPGSELDLVVR
NAADVGALALRRALLWERTKEQARLDSLTGLPAHRAFHERLEELLVHGSAPLSLALLDID
DFKQINDRYGHPVGDDALRAVADTLRSGTRGDDEAFRIGGEEFAVVMPATEAASALRAAT
RLCERVRAIAAPVKLMISVGVAEAGVHGTTRDELIAAADAALYKAKRAGKDRAVLADRPA
SDAGAIGATRSGPRGVPERHRLAVIEGGASDRTAGGSDEHRAAGDRDEAEAPAIPSRRPH
PPADRLRLAQAQGSERTAEEALGPQLAALVGALYRRDPASETHTRLTLRLVREIARQAEL
DAHTTLLAERAARVQALGKLAWPPEMLRSQRPLDRSGYELVRVHTLAGEALLRGIGAIEL
ARIVRSHHERFDGCGYPDGLRADSIPLAARLLHLAEAIAAMSLDRPYRRALTPAQVAEEL
AREGGGQFDPDLVDAALSIPGAPFANLSS
>A0A1C6JK49|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKIKHTLYILLLIFSLIPLYTFGIFMVYENDRTVERIMKENLAAISGSQIMNIKNFCDGR
KEAMEMVAQYDIVRDAVEDSLDGKGERAVNHEYLENLLIKRKTYNPFIASISIVDKNFHV
VASSEPYEKDQRSDLKHVDRKYLRGDFFIGDAYERKTDKGTIQMVAAYEGIFQDKELIGY
VIEEIASSHFDEYRSKTNLWKDGTYYILDGNGKIITAGTPEEKRKKPITTKEQRKNYQEA
WNAVDHEKNPSGEITYTYNGTEYITYYSNVNDTDWTIQITTNLSSHRATSRAYKGLLILT
IISVSLLLIVIHYFLTRRLTRPLESIIGTLDKVQEKQDYSLRIESHTADEVGAMAGEVNR
LLSYIEQENIEEKAQQRKLAKLAACDPLTGIKNKKAIEQTILDVIQNAADTQKRITLGFV
DIDDFRNFNSQYGHQFGDDVIRFVADTLTDMIPGLVGRYGGDEFLFCYEAMWDREKTEDL
ARHLLQKLNKGILNEELGRYIPTPCSIGIVSEEGSSLDYVFMLHKADQAMYHAKNAGKNT
FFLAHCEENH
>A0A380AMV9|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MYIAPPIFDARKSGLSFAKRTYLPRVAGLGLGFICVCAALYPLAPPTAVWLLLAFHGFLW
PHLAYRLACRAKEPFKAEIRNLLIDSAFGGFWAAMMAFNALPAIVILSMMSMNNIASAGK
ALFAKGLAIQLTTAMLTAALLGFPFHPHSTALQIYLCLPMIYLYPTLLGLVTYRTAKRLA
EKKQELQRISTRDGLTGLYNRRHWEHLLHRQFDSCRRYQDNATLILMDIDRFKTINDTFG
HALGDEALAALAEELLIGMRNVDIVGRYGGDEFGAVLPNTSAEQAGIVLRRIQQRLDAVS
FKEAPQLRLQISAGIADYHPALGGYLDWLKAADGALYRAKQNGRNRLETAAPPGE
>A0A737U1S9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1Y6M7B3|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MIINIKAFFKKTLRHFKLFSFFFIICSSLYFIYNIYNINKLHGQYLTTLNNIYSAARRFG
SFYNNTGTEDLKEGQYLFNGVSVVVNTSTQAKILSTGINKLRLQIDKLSENHIWTVAVFE
TSAKYSHFDPLRAIYLKLYDHVVLNTIVKNEGLIDTYQSFYGCNIKLTDIYTEQGTDEIL
RTVYFPIYNNKKLDALLAIDINNSIFKNTLDNYNRNKMTIINMNNNNFYQTQELLPCSEV
DPIHLGINFYTLLKFTFLPSILLMFLYLSLTKLITNKNFILRYDQMTHFYRRDFYETKLL
NQSDFNLLIIDIDHFKKVNDTYGHEVGDEVIRAVTKRINNCIRSNDIAIRWGGEEFMLSF
PKMNSEQLTRKAQQICDSIALYPISDIDISVSIGGVSAKNIHFNDAYKAADQALYHSKNN
GRNQVTIV
>A0A2P8VKF6|diguanylate cyclase|EC 2.7.7.65|Siccibacter turicensis|TrEMBL
MHAATLTRRMFWGQSPKRVVNICFLVVLICSALFTWRELIVLQHAYATSQRNGLENVAIG
LDRHLQFSLDKLLFYRNAMQLALAQPLNTDISRRMLADFEAQRDEHTWQLLGNNHRSMPM
NGVSDAFVNQSKLLHRDESRLAGELSAALEFGYLMHLSGGGGGGNGELQQSSWYTSRAGF
FIASDIAPGAPALLPAYYHQVTRPWFFEQSPEKNQTRDVVWFYLYDPVRNVQTLTASVPL
DYQHYWYGVVAMDFPVATINRYLQQIVDDADKGEVYLFDSRFRAIASSQDAPAADTLFDS
VDMARLAGEVEKSSQGGIRFDTRYVSWQKLNNFSGVLISVHSIEQSMQAEFGTITVVLMA
FWTLFLAMLLVSWLMIRRMVDKMTQLQNKLTWQAWYDPLTRLYNRGAFFERAQVLVETAE
KHHAPYSLIQFDLDHFKSINDRYGHQAGDRVLRHAGTLLAALLREGDIAGRVGGEEFCVL
LPNTELDEATQFAERVRARLNAREILLSPTTSLRFSASFGVSSSAEAGIYAFEKLQAIAD
DRLYKAKQGGRNQVCAD
>A0A1E7WI05|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MAGSGYRGTSGKVRRRALALALATALATALALTAGPAGAQTPAPTQTSTQAENEALRARL
IEIREQCRFLPEKALAALAQIAPELAGRPGALQADLLTIEADGRMRQGRYDDAMASAEKA
IALGRELHDDAIVAKAQLTKVYVLFARADVEAAHQLAFEAEKLAMRTNNAAVRAQATITA
GQTHAEQGNFPAALVKLQQAVEIARDVTSDPPTLAAALNALTRLLVQMKEFDQAAASLDE
LLAESAKLNSPGRMSIAKNAEYWLTSDTGQMQRAMRALRAELELERKMGAERMATTTLVN
LADLHLKLRDYPRAAQYAQEALQVTQRNNDQSTEATARVNLGNALLAMGRIAEGKRQFEA
GMARYEKENNKPELQLVMREYGVALENAGDLAGALAAYHRERALSDELFERQRQKSMLEL
QEKYETDKKERQIELLSRENQLQTAELDNRALQQRLWWLLALVFALAAVVVGLLYRKVRH
SYARLEEKNLELKAQSTLDPLTSLYNRRHFQDYMRTLAPVPSDRRGQRGDDVVGALFLLD
VDHFKHINDSYGHAAGDAVLTAIADNLRIVLRETDMIVRWGGEEFLAFLPAVARDDLDDI
ARRILHGISAQRVSYQEQEIAVNVSVGFAPYPLAPGATPLPWERAVNLVDMALYLAKAHG
RNRAYGVRGFALFERTSMEAIEQDLERAWRDGYVDLSVVLSGAPEAPPPSQDNVVRLQRA
GT
>A0A0J6Z2J3|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MTLASFAGTRAVRALAVGVVIFTASVAGIDSRLPESLAVLWPANAILLAVLIRHRAARRH
LEVWSAAAVGYVAADLSQGTAATPAVVLAVANLAGVFVALLVLVRLDVADVRVATPSTVV
RLASGCVAGCAVGAVIGATVAVSSFGGTWPEGWLSWFACDLVNYACLLPALLTVRRWRLT
TWTGAVSALRTVATPWTLLIGLLVVAWLMRDSGSAVAFTMPALMACALGGRMFATALMVM
TSTITMLALSVGVGASAAPAPVSTTTQIALALLALGPLLVAAATAERRRLLDEIRQATTR
DDLTGVLRRGEFAARAQELLAHGDSTGMPTAFLMMDLDHFKLLNDRRGHRAGDQALVEFS
AILRDVLGSAQRDDPRGAIIGRVGGEEFAALLPGVSVERARALAEEIRRRQEERARADFG
ADGSTVSIGVSGYAGRHTLDELMMSADASVYSAKRQGRNDVVVFADTVLRAVGD
>A0A8F6HPC8|diguanylate cyclase|EC 2.7.7.65|Skermania piniformis|TrEMBL
MTQSGSTAAKPTVLIVDDDGVNRTLLAELLHEECRVVLAKDGSSAIGRAQAEAEIDLILL
DISMPDMDGYEVLKRLRWIPATKRTPVIFISAAIEAESEERGLQLGAVDYVHKPIRPVIV
RARVRNHLELVTHRKELERLADRDGLTGIANRRRFDEAYDLAWRRASRIGQPLNIAMIDV
DHFKRYNDLYGHVAGDEALREIAQVIDRYATGTWDIAARYGGEEFVLLLSGEVAFGAILS
RLHGDVASLRLTFDHSGGDDVLLATVSCGGVTAITRTIASPSALLREADALLYQAKREGR
NRVLVRGDTAAVDAGSAV
>A0A0J6Z446|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MEKGLRDFLLIWWRQPFDFAWTARHLRSRGMLRIHQVFIGAFSLLYGLIALLTMLWASRD
GGAVSGQALVLVVAISSAVLGLIWIVGPFPTERQSAAFAVYADFAVLAVIACYQDAFTAM
PGLALLAANGIYIVVAHGPRALALHLVFTVAAFGWMYALALAQDTAEPSVVTVRLLVLLP
TVVGVPVIVQSYLLALRMGAVDALYDPLTRLLNRRGLDDEVIGLVPAGGAHLGVLAVDID
KFKAVNDGHGHDAGDRVLVSVANAARDAVTSLRVRSVIARTGGEEFVLVVDAGPRTVLDV
ADRLHEAVARCDTTVVPTISVGVATAWTSDRELPTAIRALIERADAAMYRAKGAGGNCTV
SADDAVPAGE
>A0A8B4S4Z6|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MALDPFTLLVLSAAMAAASALYLAAEWSSVRERSLLLWSAGFTIIAVGSVLALLRSSGYV
LFGIWFPNGLLIVAHWLFLAGVAGFTRTRLPRTWWLLAVVWLAMLFLPDGPWWSKTMLGI
QSLMIAVITLRAGLLLRPHGRALSVGAAQLRFVLLAHGLFYLAKAGSAVAPDAFVNLASF
RGAVILVSLVEGVMAIMLLAMSMTGTERHRREERIAQIAARDPLTALDNRRALYLRAPEL
LRQSSPASPGALLLIDIDHFKQVNDLHGHDAGDRLLVTLSDLIRGLLPHDALAARLGGDE
FVILLRCVSGADAQALGQNLRESFAQHARAMFATPEPVSLSIGATLFDQPETELSHWLKR
ADEALYASKRKGRNRMELAPLPLGRPQ
>A0A7Y7YPR4|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. P7760|TrEMBL
MIGNAFERFLSRYKRPQRVVNLCFVVVFLCSTLLTWREVAVLESAYISNQRNSLDNVATA
LDRQLQHSIDNLLFYRNTMHYALQSPISTDISRKTLADFAIQRTQPYWQLKLDLNRGMPV
SGVSDEFVAHNSLLGRDENWLYPELEAALEFSYIMQLADAKRDLQRRVFYASRAGFFLSS
TPPENDPAIVSLYHRLIAQPYFVAQSPENNPGRGLQWTHTDNPGSHSGQIITASVPLDLN
NRWYGVLAMDFPINGMHEFLQALSHDRYEGKVMLFDRQFSLIATAADHVSLAPVFNEKQQ
AEIARSMENGEEGELRMDTRFVTWAKLMNFDGVLIKVHTLGEGVQGEFGRISIVLTVLWL
LFTLMLLISWRIIRRLVNNMLTLQQTLSWRANYDTLTRLYNRGAFFDIAHGLAQDCQRED
KPFSVIQMDLDFFKGINDRYGHHAGDKVLAHAAALLSSALREEDVAGRVGGEEFCVLLPG
TNLPAAAKVAERIRLRIHTKELLLMAGETIKISASFGVSCAHERHDYDFEHLQSIADRRL
YKAKQNGRNQVCTQD
>A0A8B4S4K4|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MGQPADLYFALIAPACVVLFGFALLACWYVQRRQPRALFLLWLVGGYVLLATALAAQSLM
SNAQLSHFALMTACLYLLGTWSLAQGMSLRLGSEGASVPGGLLIVVVTLSLLFYFSRVEN
NLWIRVQCLALAMALQLTLAMPAFLKADSSKDWLERGVRWAYGLNVCNALFRPAAVSLLP
VHEVQELTRSGYWLLTQAIALLFAMWFAVGLLACSVRDVMTTLREERNRDSLTRLLNRRA
FMEAAELRLADQRLVPWAVVAVDIDHFKYINDNWGHAAGDQVLQQLAQLLTQQVRDCDLV
ARFGGEEFVLLLSRVQLFEAQAVVERVRERLQSQVLGGLAAQLRVTASFGIAALSSTQDF
EQALARADALLYKAKKAGRNCVMSSAQDESELQWKMFA
>A0A8J8B240|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MSFMELAQIIQLNIFSFIILVLIYSNERKMKEQLVTYKIFKFIVKVGMLLLIVDTSAWYF
NEKSGNLNLFGNQISNLILYIFAIVPVALWLLYVYFQVIHNRNRATRVIIAACLLVFVNG
LLSLMSIKTGWYYSIDSNNVYHRGPYFWVHVLLCYSVVNYTFFFILFNRRKIDKRYYKSL
LLFPIPQLVGSALQVAFYGISLNWSGLTISLLIVYFNIQDMGLNTDYLTGVFNRRILDYH
LRDKINNTSKNKTFSAILIDLDDFKKINDNFGHHVGDEALQETVGLLKSSLKKESFIARF
GGDEFIAVLDIDSIKHLEMIIYRINNNVRAYNQTSGKPYEIKLSMGYCVYDYSSKMKVEE
FIRQIDQLMYENKKKGK
>A0A841GJF4|diguanylate cyclase|EC 2.7.7.65|Thermosipho japonicus|TrEMBL
MNKKVLIVDDSKLWREFLRSIIEGFGCTVKVASDGLEAINKFFEFMPEIVITDYIMPNMN
GVHLTRFIRSYPQFKNVGIVILTAENESINPFWAKESGANLFLQKTLDKEKIIEKLKKFC
ERGYTIEWSMEFYKVKKEPYGELVDLLEERLRNEIIISEVFGLLQYIEDEEYLLNKFFNI
VVSFFDPRSIHVLLITLAEGRIYSCSKNNEKFSLDNVKEKLFENLKKPVTPSKWKYVGNF
SKDGRSLNNIKSFVLEHNGIEQGVILFENVEKDNDFKKYLNVALEPLGLVSKILNDFSDF
KIKVEIDNLTQVFNKQFIISKLNELLKMHRRQNLPLSVVMIDIDDFKKINDTYGHVKGDE
VLKQFAKLIKEGLRESDYLGRYGGEEFLVIFPATSCFDAKKVMERILDKVNKYNWKEELG
IEKVTFSAGVCCDLSKTVLGLINMADEKLYRAKRNGKNQVVGGE
>A0A8F8C9Q6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MESRNSAPLASYMDLLLDAVCAVDRQGRFVFVSAACERIFGYTPDELIGRPMIELVHPAD
RQRTLEAASDIMGGEPKHNFENRYVRKDGRIANILWSARWSEVDQLRIAVARDITERKQA
ESRQAALYAISEAAHVAEDLLALFKRIHLIIGEWLPALNFSVALYDEHCAQLNFPYHVDD
HELQPEQPGTVTWRLCAQVIRSGQPILLTPDSPDASSDFAALVAGQDSPCWLGVPLNSKN
GTIGALIVKSLPGGERYTEQDKELLQYVCAQVATAIERQQLYARLKRMAQYDQLTQLPNR
GLLKDRLKAALAGARDASGNMALLYVDLDRFKQVNDTFGHAVGDMLLQTVASRLKGCVRD
TDTVARIGGDEFVVLLHSIHAAEDADSVAEKIRQVLVQPMRLDGHNLHIEPSIGVARYPE
HGSEEQQLFRHADQAMYAAKRLNHRLVDI
>A0A1V4XPP6|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaB.Bin138|TrEMBL
MALSKGFSATPQDVTTPDKNQLSPPLLLVVDDEREITASLADQFRRSFRVLTASCAEEAL
AVLKGQEVSIIISDQRMPGKTGSELLAEACRIDPDTTRILLTGYSDIEAVIQAVNEGKIF
FYLTKPWRNDELEAVITRALEHHRLLKEKRQLINELRRMNAELEERVKERTAQLEQRAAE
LEEANRKISEMAYRDPLTGVANRRCLEETLLHEASRGARMGLPLTVIMVDVDHFKSVNDT
YGHAMGDKVLQAIAHTLTVQSRPYDLVARYGGEEFLVMLPAITLENGRDAAERLRAAIEV
STIEGFPRKVTASFGVATMEPGQPADTLFERADNALYRAKQNGRNRVELDGNTSTNDVDS
P
>A0A7H4MH12|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MILDIDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPE
LHALAQSILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRV
EWAPSAGAAG
>A0A5W2JK38|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEFGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0T9NUL9|diguanylate cyclase|EC 2.7.7.65|Yersinia pekkanenii|TrEMBL
MSSIKHKSAQQTKKHNNSAKLPTLGRVLGRIHLTVALVSVATAGIFLTLAALFALRVYAD
HNLHLVARAISYTTEAAVVFGDSVAANEALSLIAANEEIAEAKILDLNGRVLASWTQPDN
GPLHQIEQGLAHWALPNPVVLPMIHAGNEIGRIVIIGHGGSLLRFLLQGLAGMLFCLVLS
TVVALFLSRRMLFGIIESLNRITEVAHNVSRHRSFGQRVPSAKIAELNELSNDFNGLLKE
LEVWQAHLTQENDFLAHRAAHDSLTGLANRAFFEGRLSRMLRDCDANEHVAVLFLDGDRF
KEINDSYGHAAGDVVLTTIADRIRALLRETDLVARLGGDEFAILLAPIHNANDVITIADN
IIDSMAQPIVLVDGSEIKTSLSIGIAIYPDHAQTPEELLQRADEAMYQAKKNFQSGGRVI
ANQSDVIHTENLRQLICRD
>A0A2H6JDK4|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin12|TrEMBL
MQRILLIERSATLRHAVGKRLCDHGYRVEQLSGYDQALERLVRAGEDPDYSGIVVGWPTR
TDPHADEFLSVLDDPERRGQAVLILAHDSGATLREWVSNRAGTALLLWDNYTEAVPTLGK
LLTPRVREEHDAPSSAVDEHSIRILFVDDSPSVRGFFRRLLQRHGYRTDTAAGVSEGMEK
ALHTKFDIAIIDYYMPEATGDVLCRKLRENARTRGIMSSIITSTYLEQVIRDCLDAGAVE
CMFKNEADELFLARIAAMERAIRFQRSIEAERRRLEGILSSVGEGVYGVDEAGRITFLNP
AALKILGYPEDERLEGCEPRALFHYADEHGTAIEAQACTLTRAYGGHEEVTSWETVFWSR
AAKPIPVECTVCPLTIGGRRRGSVVAFSDISERRILEDRLRWQATHDPLTELINRRYFEE
QLGQEVRRLKRSGEHSALLYIDLDRFKYINDSAGHAAGDQLLIAVAQQLRILLRETDLLG
RMGGDEFAVILRNITPGHVHDAADKFRNLLDRYSFVDGDKQYRVCASIGVAEMDKNSPSP
GDVLANADIACHVAKRAGRNQIHLYEDGRKEKEAMEQDLGWHSRLREALQYDRFVLHYQP
ILPMEAVDIAHLPERAGVLWTELNRRAPHGPICLEVLVRLRGPGGTLIPPNAFLPTAERF
GFMHEIDVWILTRALEELVALREAAQRVVLSVNLSAGILEDRFALPYIKGTLEDLHLDPG
CLIFEITERSAIHNLEAARRFIAELKNLGCRFALDDFGSGFSSFSHLKHLPVDMVKIDGS
FVQDIAHDPIDWAMVRSMNDIAHSLGRRTVAECVENAATLRMLKECGVDFVQGEYLAVPI
LSLEEAVHGVGDPPVVAAWASTARRH
>A0A6N2XVH3|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKQIIRKRLCIVILTAMLTTLLINYYIEIHNAQNEMYTRAQEMFWQVGQILDQNEKEAEK
ERENLKEQCFIRAKAIAYILQDRPQVTGDQQEMEKIARLLQVDEFHLFDTKGNLYAGSEP
KYFGLNFNSGQQMQFFLPMLENYDLQMCQDITPNTAEGKLMQYAAVWREDRKGIIQVGLE
PTTVLDSMKLTELSYIFSLVTSEKDSTVYAIDPESETILGSTDETLVGKQIQDIGLHPDQ
MSVTSRGVRAVLNQKDSYCVFGKSNSVILGMSTTSASLYREVNRSTLMVAAYLIGLSLLM
ITFISKDMDRYILEGISSIHNKLAKITRGNLDTRVEVDSTPEFRELSFQINKMVESLLDT
TNKISKILEMVRVPIGVYEYNRDMKRVMATSRLAGILRLKDQEAEELLADHCLFEQKLDT
LRSRPVEREERIYRLEGADLRYIRLESFERENSVLGMIADVTDDIMEKKQIERERDIDLL
TGMYNRRAFYRHMEQLLREPEQLEHGMMLMADADNLKQVNDKYGHENGDRYLTAIAGLLK
GCGWNNCIAARLSGDEFALFLYKCSSRNQLMEYEAGLRKTMETCTAELDNGERIQVRFSD
GYAFYPEDGTDTACLLKHADESMYEAKRAYKAASVGKKDESRGSKEGNVS
>A0A448C464|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MDTGLKFSLPKWRLTRWLTHSGPDTPADIRAALIASLFGTLPIFAGGVINTLMISGVVAW
RRPEPLYVSWLLLEVVLAIVRVTVLRAALRAAPKGGNTHTDLYILLALGWAFSVGYGVFI
TFLNGDWLAATLAGVSCGAMAGGICFRNYGAPRLVAVMIFLSLGPMCLGALFTGEYVTAI
VFIQIPFYLASMTIASHRLNRILVSTMVAERASKRRANEDALTGLANRTGLQVALERVCA
SARGQDSDAALLYMDMDDFKRINDTYGHAAGDQVLVTIAQRMRAMLRVDDVAARIGGDEF
IVLVTGIDATSARRLGEHLLLDALQPIALADGTRVIVGLSIGISIISATNRSPQAALDSA
DAALYRAKARGGRCCEVDNGEAEGQPEPVAGSSSEPATA
>A0A0A6ZSQ3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MMPLISVFQLTYTYEARKPGINHLLSIDMDKLKQINDTLGHQRGSLAITLLAQAIKQSIR
KSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTL
HDAYKASDERLYVNKQNKNSRS
>G8AR90|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MSAVVTTQDPDVIAAEHHDGLPFDRGTHDRLLRMPPLRGSRIAHSAVPVTVDASALESQL
AEARATIAEQRERIAYLESLSMTDELTGLLNRRGFFSHFRREIAAARRQRAKGNGKGGGV
LVIIDLDGFKRINDTHGHMAGDAYLRQIARLLVGAVREEDVVARLGGDEFALLLTNTDAA
CGAARARQIATMACRRGVPWSNAELPIRFSFGVQPYGADDREEEVVRLADSHMYRNKAGR
RLRSPGRKAAQPVARSAANRRATA
>A0A448S2Q4|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MMGLFRRKRAAHARPTLGQVLQRMNLSLALIAVGTAGIFLTLVALFALRAYANHNLHLIA
RSISYTVEAAVVFDDRSAAREALMLIASNEEVSEAKILNKDGRLLAYWHHPKDGPLHGLE
QMVARWAMPEAIELPITHEGKQVGKVWLSGHGGSLLRFLLRGLAGIIACLALSTLCALIL
SRRMLHGIVRSLNDIANVAHVVRSDRSFGQRVPSAPIAELHELSNDFNGLLEELETWQAH
LKQENDSLTHRATHDSLTGLPNRAFFESRLSHALNHIAPEEKLAVLFIDGDRFKEVNDSH
GHAAGDAVLTAIAGRIRAQLRDGDVVARLGGDEFAVLLSPVRRQADVTRIADKIIGSMAQ
PVPLPNQEQVIASLSIGIAFYPDHAATPQGLLHEADDAMYQAKHRYHGGWRLATQK
>F5NY69|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGNLRYPFLNLTWAVSTLCLLNYHQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAA
>F5NZ20|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MHNGLVEALKNITDVVYDVRSNRNFTRRVSEERIAEFHRFALDLNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7U7J2I0|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MRIAESRPMVSSWFSVPLTLVLGLGLTSALFLIEQQSIARYGLILPIGLLGTALLAWTLR
QALVREAAAEVLAHERAAALHESELKFRRMLEEIPNISVQGYDQNRRVIFWNTASERLYG
YCRDEALGRLLEDLIIPPPMRDVVIQAVGEWVAGGQPIPCSELELLRKDGSLVPVFSSHI
MLTTDQNQQEMYCLDLDLSERKRIETALTQRDALLEVAALTAARLLREPDPVLAIASCFA
QLGEITDVDRIYLFENHCCPHTGDLRMSQRHEWCAERVSTQIDNPELQNLSYEAAGFSHW
REVLAANAPIAGLVRDLPASVRAMMESQEILSLLIVPISVHGEFWGFIGLDDCRRERQWT
SAEQRILQNIAGNVGEAIARQYAETALQNSEDQFRRLADNMRDLVCQIDITGTILYASPS
YRAVLGYDPQALLGRSIFAGVHPEDRETAIKTCQASLTQREAGRTEIRHQHANGDYLWLE
VVGNPLCNPAGAVIGAVISSRDITERKQAEADLRLATQVFESSREAITVTAADTRILWVN
RAFSDITGYSAAEAVGQTPRLLASGRHGRDFYQEMWRALTVTGRWQGEIWNRCKTGEIYP
EWLGISAVHDPQGHLTHYVGIFSDLSEHKARVDQIEFLAHHDPLTALPNRLLLQDRLDQA
LSQAERSQSSVALLLLDLDRFKLVNDSLGHALGDQLLQKVAMRLHQMLRDTDTLSRQGSD
EFMIVLPDTGHEGAGHVARHLLECLDRQPVQIADHSIGVTAGIGISLYPDHGQDRDSLFK
QAGAALRYAKNGGGNTYRFFTASMNVNTLERLQLETDLRHALERNELLLHYQPQIDLRID
RIVGVEALLRWQHPERGLVSPGQFIPIAEDSGLIVPIGEWVMREACRQIHAWQQAGLPRI
TVAVNLSALQFQRTDLLDAVNQALTECGLAPEWLELELTESILIQDTDNALRTVRQLRAM
GLRLSIDDFGTGYSSLSYLQKLAVHTLKIDQSFVRGLASDADSAAIVRAVVQLAHSLKLN
TIAEGVETDFQLAFLRNQGCDQVQGYYFSRPLPAVEFARLLAQNTLPVA
>F5NUH5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MTISIGTVFSTGDTRNISLVMTEADKALREAKSEGGNKVIIHNI
>A0A5P9CAN3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MPSDNPHKREARPEFWQLSMRCCQLAACVDVAFLFIFLGLGSPILGWVNVISVAMYVYAY
RAFKQRRNRLAVMLIRIEVLVHAGLGTLMVGWESGFHYYLLMFIPALFVSMRARSAWILA
ICLWAYYVGLDVLMWYLPPLQPISSNALLAVHVFNLTVVFCMFSYLALFYVVTVTRAHKK
LARMATTDPLTGLFNRRHLISLAEKVQQPAEMTLMLMDIDHFKAINDAYGHDMGDQVLKA
VSRVLKDSMREQDFIGRWGGEEFLALLPHTDLDQAAASAERIREAVQALRIDGNGSHIGV
TLSIGISQHHAGQSLSHSIARADAALYEGKSAGRNRVERAPS
>A0A7U7J454|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MNVFAVNTDYIYFIYGLSFLLLATRALALSGRDQTLPWRWLAAFGLLHGLNEWLDLLALS
LGDAPVFKEVRLVVMIMSFLPLVEFGRRGLMRQGFKSLGGWIYLPLLALVGLGGWAGISG
LNIAGRYALALPGGLLAGCTLWRAAATVEGERYLGLRWAAGSMLLYGLAAGLIVADADFP
PASWLNYDRFFAATGIPIQLVRALGAIGVMTGIWLHGQQPKSKKGRFGGIVRWRYPVAFV
VLVTLGWLATEWRGHSVEAEMRERLLRQAMEIAQALPVGEVEALSFTATDRGTPAFERIR
ELMIAYGRLVQQHSIYSMALRDGAIVFGPENLAEDDPWASPPGTVYRQPASENFEMFRTG
QPVAFGPWQDEYGVFVSAVAPVRDLHSGKVLMVVGLDIRVSDWNHQALASRLVPILSTLL
LLTLLLGGAGAIQWRNRQAASRRLHFRHFETALVGTLGLALTLAATLLVLEAENRERGVF
FHRLADARAGNIREVFSDIRAALSALAQFYQASQQVNRAEFHAFVAPLAKATTVQAYEWI
PHIPAADKARFEAEAQGEGSGDFIIWEHNAQGERVPVSGRADYYPVYGLEPRVGNEVALG
FDLGSESIRRTALETALRTGLITATHPLTLVQETEHQSAILVFQPVFAPVLPMPENSNAG
GDAGRLRGFVLGVLRLQTLLDRALLHGIHDSDEVAVDLIDLMIAAGPTLLAVHPHDYESR
HIEAITVARFEQREFQAVHPLFTFGRAQAVLIRPTPLFHAAHPARAGWLTGLAGLLLTAV
LATFVGFLRNRQAVLEQQVQTRTAALQESEEQFRSYYELGLIGMAITSPTKGWVQFNDRL
CQILGYPRAELVAKTWAELTHPDDLAMDMSQFNRVLAGEIEGYKLDKRFVCQNGGIVDTV
LSVRCVRDPAGSPRHFIVMVQDITERKALERELRRLATTDSLTELSNRRHFLAQMTQELV
RFKRYARPVALLMFDLDHFKRVNDQHGHAAGDDVLRHFSAVARQMLRQVDLLGRLGGEEF
AALLPGTDFDGAQQLAERLRRRVAESPVTTAGGVIRVTVSIGATSFAPTDPAADAILGRA
DRALYRAKSQGRNRVEIEWPP
>F5NSB5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MVKERVYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPS
YLYDVGPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTH
NRSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFA
YLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNH
FERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVD
KFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYCFGGDEFAVIYTGGTLEELLSIL
KEIVHFQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>H8KYR7|diguanylate cyclase|EC 2.7.7.65|Frateuria aurantia (strain ATCC 33424 / DSM 6220 / KCTC 2777 / LMG 1558 / NBRC 3245 / NCIMB 13370)|TrEMBL
MPLTPRQESDEATRLDRMAQSWRDHLSKAPQATLQLLAALPGPVVADLANDFYRALLDDP
RASRFLSYDDVWTRLKPALERWLHAVLKAKSDDAMELTQLNHRAGSLHARIDLPVDLMTQ
GFRILRHRLAEALQREEPDPALAYSALCVAGESMDLGLEGMSAAYVSGSERSARSDATYR
LFSLMRNAGTERERQRAMLLDWENSLLYMMASGGDISSISTLTETEFGRWFIHKGAPSFG
DHEAVVTVQRAMLAIDALLWRLPDAGSDRMHLLEAIRDHLSNIRQSLTVLFEQVSELDSG
TDALTALLNRRFLPSVLRREILLSDRSGDRFALLLLDIDHFKTINDRFGHAAGDAALRHV
ADLLGRLTRGSDYLFRLGGEEFLVVLVDCEEARATMIADQICRQLSATPMDWSGVDQGIT
VTASIGVAAYDGHPDYEYLMRRTDAAMYQAKQAGRNQVCVSRISPTAD
>A0A7U7GDE6|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MPALALKTKMTLAVSLLVAGIALFIGFVNLFEFERYYKKMLADQQFLLISALVDEIDDKL
ATAQNSLVAVSRLITPGMISDKQEAQHFIEDRVGISSIFEGGLFLFSTTGKVITHNTHHE
ISSNNYSYRDYFKQTMATAKPVISEPFLASFAPYNPVIVFTAPILDNQGKVIAIFAGVID
LTKDNFISKLSSIRIGESGYLYLFNRDRMMIMHPDKNRIFAKDVSIGTNKLYDAAMKGFE
GSGETVNSRGTPMLASFKSLKKSGWILAATNPQRQAYAPLVAARRQFYLLLSTVIGMAMA
LTWLLMSHLTAPLLAVIDHIAVMPLKQGDDRFLHVQTRDEIAVLATRFNQMIMEFDSQTE
AAQRLAAFKKAIEADDSLEDVYVRLGCIFQQFGLRDSLIYQISDDQHKMRLIYPSIRDYE
QIPGDNVTPNQSRLCEKQPATDDRARASLIFQRLCSPFPGESASPYHCIPIIAGNSLIGI
ARFPVNPLAANSPEMTRKIAQAEQYIQESLPVIEVKRLLRKLKESALTDSLTGLHNRRFL
QEYTENLVASMQRHQKTIGLIMCDLDHFKQVNDQYGHDVGDIVLKKTAQTIKKSIRDSDL
VIRFGGEEFLVVLLDIETGSAAAIGEKIRETIQKTTFPLAKGTLKQTISLGISELPHDTD
RFWQSIKFADVALYQAKAAGRNCVVRFTEAMWRKT
>A0A549ZW15|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MRILVVEDSKVVSRILQHLIAQELDCEVDFAVDLASAKIFLEQKQYFVAITDLNLPDAQE
GEIVKLVLSKKTPCIVLTGSLDSEQRKRLLQLGIVDYILKENRFSYEYVVRLVRSLQRNK
DVKVLVADDSVVSRKFVRSLLEQHLYQVIEADDGNSAWEVLQQQPDIQLLITDYNMPGLD
GFGLILKVREKFSREELAIIGLSSDGDESLSARFIKNGANDFLQKPFVHEEFHCRVLNTL
DSLDMIRKLWEQANLDYLTCVYNRRYFFGLFEDQLEQIKQKQGTLSVALLDIDFFKKVND
TYGHDVGDEVLVEFASRLQHFFGQHFTVSRFGGEEFTVAFKSLKQEKAFALMDKFRSQLE
IQPIATSKGDIFITVSTGIAELSDDSLDAVMQRADKALYDAKESGRNLVCID
>A0A173YE05|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MNLRKQLFTSFLMLAMLPLAAVGIYIFATNLILAFDLHEQNLRDSTQIQAELVEENINRL
MVRARKFVSSQEVKRVCGDNSHRGEGTISELSDDILNFTDETLDNVAIFALLDLEGEIIY
SSGSVSDSRVLKANLPTLSQLEQQLVSEIPFTDPGNSLVIYTPVQENKTAVGTLVIVCRT
DYFLKLISSHRQLESSNALIYCREHHQIITSKQDVSGSLSELDLKVGEESRGGLLCKMND
QYNLAYYQSLSKTPWVLVSTVDTAQIFSKVKNYGLINIAALLTVFFIIIILSRNQSRKML
YPLDQLLGAVEEFFLNGATKFPEADIDPKTEIGYLAEKFSNLSDEMTLVQDKIRESNYLY
AALLMATYEFRIVIDFQADTVECSSGRLSARIDDMQGRTASERVLALFSEEGQDISPDTA
LYRIVCGKLTEPMETETCFSIKENEIRKWYRVVAVPVIQGSAVWRAALHFEDITDKKLEE
LRLIQSSQTDPLCGLYNKTAFPLHCKLSREGRQDAVFFIDLDKFKQVNDTLGHAAGDEAL
ISTAQAIRAQFRECDVVGRFGGDEFVVFAPCIGREMAEQKAERLVQAVSFLLDAPPDGQI
HLTASVGVYMVTPPETLDDAVRRADEAMYRAKEKGRSQYCIM
>A0A649YNZ4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MPPFFVLIVAIFISTLPLPAMSACNIQTDSDYLYSHTNAKQKAMLTFYYDSLCKPGQVDL
SHIELPPNASASEQALYYFGLKNLRKYEGLQTPRIPDLLSLGDDSRIEWVSAEATLNKAI
HLIESDLLLEGEFLLHEVVPIARDIGYKRLLGRTYRWLGNVKIQRSNLKSSLSYYKTAYE
VMTEIGDNFQTTMTLNNIATVYMQSEEWKRANKYIKRALDLYQKHGYDNSLFEAIMYSNA
SAIYFALGKEERSEQYMLKALKEADKTGSNKIKFSTLSNMSQRYSDVGNSQEALKLARKC
IEESQVLDTKSNITLATCYEAYAEASFVARDYQKSIDYAKQVIEVLHTSESNEVVWEIQT
LETLVKAYEAQGDYQQALAYMKQQSQVRQNFYRQTYDDEILSEKNALERQLNKREIELLE
AQNELQQTKLRSQRTREILFITLFFALAYLVIRRLWKMKRITKELESQNTTDPLTGLANR
RYIENWLSQSDNVQQHKSYALSVIDIDHFKQFNDTHGHDVGDTVLKATANQLKNNTRSHD
IIARWGGEEFVMIIPIDNVHTVEETLERLRKSVESHKIHIDEDSLAVTISVGTQLCHYQD
IETDWDRVFRKADKALYQAKQSGRNKCITFHYQD
>A0A7W4XQB6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas umsongensis|TrEMBL
MNELQLDDFKTDENAAMVLLVDDQAMIGEAVRRGLSNEENIDFHFCADPHQAIAQAIRIK
PTVILQDLVMPGLDGLSLVREYRNHPATKDIPIIVLSTKEDPLIKSAAFAAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYLELEWRRSLRDQTQLSLLMIDVDYFKSYNDSFGHLEGDEALRKVAMAIRDASARP
SDLPARYGGEEFVLVLPNTSPGGARLVAEKLRQTVVGLKIPHVFPTEGSCLTISIGLSTV
IPQPGSDCRQLISAADKGLYLAKNNGRNQVGIE
>A0A0W0TF69|diguanylate cyclase|EC 2.7.7.65|Legionella erythra|TrEMBL
MVIPVVMIVFGIVFLINGAYLVNRLLQQTNQYRWQWLAYLAFISFFILSYTASIFYGLLV
DPHCLNYFYASVFLMGATTIDFSCRLMTKTMQKIELMDDIKNRYDLLRHHATYDSLTGCN
NREYLFDVLSTRFQQIKLNGGEVVVLFIDLDRFKAVNDRFGHDVGDSVLQTFGKLLRQRL
RKDDVVARYGGDEFIVLMENTSLSEAKRIAENLVTVANQSINEGLLDSLDLGCSIGITQM
SRHSDSVNAAIKEADLACYAAKQRKIDGAVCLYSPMLAATNNHIVSCIKQMAK
>A0A1I1L2R2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. OV038|TrEMBL
MPWRKLVPQPRWLPRAAVMRPQRVVIWCFSLVLALTLAVGLRDLYTLRERVIASHQHNLA
LRAMGLEAAVSSERFRLSFVRDYARQLMRMEAVQARGVSDPVLDRAFAARDEPIWQMEVP
LGDAPVIGVSPQALAGLPGFERHVGDLRADLFAARQLSHVLGLTMGVDEIRNSVTFISSN
GFFVTYPPVPADKAPALLQRFASMPYYRDLLPDRNPGQDLRWAPPYRQFESTELRTTLSV
PIYVESRFRGVVAVDVSLKHIQALLGAPSDDSPALNRYLMDSAGRLIAAYHDHLSTDLRW
PDVLGDTWRDVGPQTLFATDGPGMRKGDGGYLFYQRLGTGQWMLLEAVSTAQLYGEVFSR
ISKPLLPIWIALPLLMWVSVRLVSLLFSYYLALGDKLQKLAERDPLTDLANRRHFGDQFA
QAAARRARDGSALSMLMLDIDYFKKVNDRWGHASGDHVLQRLATALRENMRAVDTPARLG
GEEFAVLMPGATLAEATVSAERLRVALAAMPVEPAPDAPTSATQGDPGARIRFTVSIGVA
EAGSDGGQTLDAMLATADRRLYAAKAMGRNRVCAEDARAGNAEAPPVAG
>I6CQI9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLG
SSLPLSQADFGLWFNHKGRHYFSGIAEVGISPV
>A0A5E1ABV0|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRSRPFWQLAVDT
KRTLPINGVSDAFVEKTTLLNRDDELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTETATQTADIIPRYYHLVTQPWFTQQTERNNRARAVLWFITSPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRMLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIENNTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
GQCQAQSLPFSVVQIDLDYFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKEILVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDHDKK
>A0A2W1JLU3|diguanylate cyclase|EC 2.7.7.65|Acaryochloris thomasi RCC1774|TrEMBL
MKPQQTPDFLRKSSLALAIVCLVFLTPFAINNFIQGRLLLGTGSLALIAILIFNTWTITR
YNRYYDSLTLLGLVPAILFFLVTSLRSQGIIGVLWCYPAAASFYLLLPERKAWIANVALL
IVTLPVAWTVIEQVLAVRMMATLVMISIFLVIFVRVINEQQYKLKLQAATDPLTGLLNRT
LLEETLEQATAQSHRTGVAMTLAALDIDHFKSINDTFGHAAGDQVLRRIGQLLQGRVRRV
DKVFRLGGEELLVLLYGTGGKNGSSVAEELREAIAALELLPDRPVTVSIGLATLYPQENW
KLWLKRSDENLYQAKAMGRNRVVT
>A0A411ZES0|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MFRGFSLQHGEILQELLAETAGSLVIKTDEGGFIENASRGIERLGLRLSEMLFRPHLADL
TSACHAEAIRAYHHDTIKGSSPIKRLEFPLVLPDQEPSWFALSLRALAGDDLTKAGALGL
LRSVEGQRNLEDELSNAAMTDATTGLANDKAFRAMLSHFASGETGGVVAVLELDRFSALK
LRFGHAMASEMLWAFGRFLANIFPPDHLLARLDGDRFAVLMPDLSGERALALVKGALATF
EQLSMQSQRADMRLTASAGLAAMASSTDIILMQAERALVVARALGGHRAELRADVPRWAA
N
>A0A484YJT9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MTASGIRPGIKCSLTPAGLIAGGLRPCDVAGRVGGEEFCVVLPGLALPQAAAIAERIRSR
IDSKEILLKKSTTLRISASFGVSCAHEKGNYNFDQLQSIADLRLYQAKQRGRNQVVWQDH
DKK
>A0A498U260|diguanylate cyclase|EC 2.7.7.65|Bacillus safensis|TrEMBL
MLRDLFINLTILVTFHYLFILVFKENFLKKEDTLLRQICKGMLSGLLGVLLMFFSIKTGP
AIIDLRHIPLILTAFYGGIAQTMIAAFVVIIGRLLIEANLASSINIFSMMFIAAASFLIA
ERHMNHVVKMLLSITIGNVVATSLFILIVHETSFQLHSTYWIFSYIAGLFNFYVIEHQTK
AYQLLNLYKFQAHYDFLTGVLNKRKFDEVLSDAFTKKLKQPIHQMSLIYLDIDYFKTIND
QYGHHEGDIVLKEIGTRLIKNTRSSDYIGRIGGEEFAVLLPNCTIEKTWQIAERLRKKIA
DQPIYLKNGMSIHTTVSIGCAYSHGTGADIKQLPFIADQELYKAKESGRNQVSFSERKKD
HLT
>A0A173KSD7|diguanylate cyclase|EC 2.7.7.65|Sphingobium sp. EP60837|TrEMBL
MRARLALDTQQSAEVQDSLVKSLYASPASLMIGALAGGALSFVIAYNAHRIEITAIAALI
VLVALSRSVSAVYFQRQLAHQDGPAQPIWGLAYELGAWGYAALLGLLAFATLTLTGDASL
HMLSVCLVAAYSGGIAGRNAGRVHIAIGQTCFALLPTTLGLTIAGGLGYWVLATMLFLMI
FAMAEISRTTHRIVVEALQGKHEKTQLATKFERLARFDSLTGVENRMAMQMRLRELFDKR
RSDQDPMAVFWMDLDRFKEINDSLGHIIGDQLLCTVAARLSHALDGRGHVARFGGDEFIL
ICPGADRTIAEQIAGDVMAEFSHDFDVSGYHLTVTASMGIAVAPDDGRDTEELLQHADMA
LYHAKHAGRNRHAQFNWSMKERQNRTYELEMGLRSAMANGELLLHYQPIFDTVTGKIAIC
EALMRWDHPVLGRISPAEFIPVAESSSLIEPITAWALEQACRDAMRWEDNVRVAVNISPA
LIKSDGLPRAVIAALMGSGLKARRLELEVTESIFLEDSGRTSLILSELQRIGLRLALDDF
GTGYSSLGYLRDYAFDTLKVDQSFMRGVGEKGRDRAIAQSVAYLAHSLDVETVAEGIETE
EQLRYAREMGFTNVQGFVLSKPIPLDDLLAMMAQMKRDRSNVVTLMHDRRRA
>A0A2C9DC76|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MHDSPRLQDDVRPAAEHPVYWLSPAGLAVPPVFGSVMPFPVSQSGTRPDDVICLIGLGAS
NPERELREIRRQFGAAPYLLAVASLGLSTETRLRLIELDADDVIGDHSREDLLIALARAD
RVLAERRLSSLRIDRLERERAYLQASIDSLPPPIFFKDRAGIYLGCNKAFEAYIGLSAEQ
VVGSSVYDVAPQHLAQIYEQADDELMAAAGTQVYETQVRFADGSFRDVCFHKAALVFDGE
HVEGLAGVMLDITKQKAFEAQLKEAAERDPLTGVYNRRKFMDVLDQRASAAASGDGHGFA
VAVIDVDHFKRINDTFGHAAGDAVLCRIAEIGMTCCGEDDLFARAGGEEFYFLIDEPHGG
RAEELAQALRLALSRICLGEGAIAPRVTASIGVAHFRPGREEVHETIRRADRALYSAKDA
GRNQVMMAA
>A0A1V5WWY2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin207|TrEMBL
MESLLDPNVVQAILDNLSEAVCAFDLQRRITYWNHGAEELTGFAAQEVLGKKCSAGILIH
VDDRGRPTCQSGCMLGQALRDRRTNDADLFIRHKNGHRVPVHVRFAPLLNQQQDVIGALQ
VFREGTASLALAQRVRELERLSFLDPLTNLANRRYVDITLRSMCSQLKHGGIPFGVVLLD
IDDLKTINDHHGHEAGDMVLKAVAKTLLETSRPFDVKGRWGGDEYIAIVSNVNSVGLAQT
AERFRALIEATAVPYHSIELRTTVSVGATMAQPSDDEFSIVRRADEELYSSKTSGKNRAS
ITGVRMVG
>A0A518I6B3|diguanylate cyclase|EC 2.7.7.65|Gimesia fumaroli|TrEMBL
MNSPLIANSNSMPQQQSVHGSYNMGSSQILKELIALSNEHEEFSLESGETDFVDQVISRK
HLRKLLTALQARDASTLCHSRRVAFLAKGIATNLGWEGIHLKRLEIAALLHDIGKIGVPD
HIMLKPGKLTSDEIELMSHYHNIGIDVLQACQTDHEVLTILSQTRYHFSGATNGFQYIGS
DVHQGARILAIADAYDSLATDQVYRAGKKHDEIMAILMEAAGTQFDGNIVCALSRWEQNE
QDAFHDALLEVNRLYQPKPFSEQEAQEANLINNIFSYLFQIESLYDGFYIVNADFQFLLF
SPGLEKLADIRAIDILGEAWTANSLPLTNKEGTSLTRAECSMNRVIANGKPMTTEFMLER
PGGRLINIEVQSVPMFGENGHLIGIAEIYRDLSRGLKRPQEFNDLKQAASMDALTSVANR
GELETQLAIMLSRVNKETNPAPLSLMFIDADHFKNINDSYGHSVGDDVLIEMARLFQHET
YSGELVGRYGGEEFVILCPETDLEHAVKKAERLRLAINNLKLEKLGKTGLSASFGVAQVE
EGDSVESLFRRADSALYHAKETGRNKVCSLTNHQLLSGINPINDSVETTVDEMVFENTFQ
ALISSDIIVYKLGGFVNDNGAKLTEVNTNRAVMQLGKSGLLPFWGKIDDRKPVEVEVEFG
CAAKKTNSNSRSSTPRVDVKIRISPLGWVKKPQLFQQRANRVYRLLKDYFAAE
>A0A841K405|diguanylate cyclase|EC 2.7.7.65|Chelatococcus composti|TrEMBL
MTARILVVDDTPTNVKLLEARLTAEYFEVLTASNGPQALALCAESLCDIVLLDVMMPGMD
GLEVCRRLKSDPATAHIPVIMVTALDEPSDRLRGLEAGADDFLTKPVDDLALIARVRSLV
RLKTLTDELRNRVLASRGLGIVEDPLAGATNETGRDAQILIVEDRPEAAAQMQQALAVDH
AVHVVQTPAEALARVGDEDFDVFIVSLGLAGADGLRLCSNLRVMERSRNAVVLMVADESQ
RPAILRGLDIGVHDYLLRPVEHSELVARVRTQVRRKRYADSLRASVQASLALAVLDPLTG
LYNRRYFDGKLRTAFTQARERGEKLSLLILDIDRFKLINDTYGHDVGDEVLREFARRVQT
HTRGIDTVCRYGGEEIVVIVPGTPLEAAEAVAERVRTRIEEEPFVVPRCKISLDVTASIG
VASLLPSDNSVHALFKRADRALYQAKTEGRNRVVVAAGESA
>A0A443ZQX6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas alkylphenolica|TrEMBL
MTRQSPTFRRFLPRACTHPRRTVILCFLIAFIITLVLAGHQYYQLQQRELQDRQHQLHVQ
ALAIEAVISGGKSQLKFLRHIAERQLIEAHTQPDLRHNQAIDAAMANARQPVWGMPVPRS
DAPVRAISDAQVANIPGLGREPEQLAEDLHLSRAISQLFPAQFQGETQLTRILYLSTSGV
VIAYPPLRDTQLEPVLRKFSSTPLMHTSRANNEGLDITFYPLPGTELGTMPHLLLSTPVY
LNAVMRGALIYDVPQVRLQNYLYQTTQADEHTALIDDDGNLVASSDPALKPVKGNWLNSL
PVSGTRVSIPMLFQRDAGTLDLGDGYLQYRELQGIDLMLASYISSSDLRAAANAQMSALF
LGTWALLALLMVLTLYIVDRLFKGQLRLNRQLRELGLVDGLTQLANRRRLQSDFGGLLKR
LQPEQPVALWMLDIDRFKRINDTWGHSAGDEVIKHLATLLRALVRPQDLVVRYGGEEFCV
LMPDTTLEDATQIAEHLRTATEQSVCVPDAGTLLAGAPSLDIRLTVSIGVAELRVDGCEG
LEELVATADRRLYAGKQGGRNRVVNHD
>A0A518IAE3|diguanylate cyclase|EC 2.7.7.65|Gimesia fumaroli|TrEMBL
MSLRFKTNYRIRLFIPTLILGMIVFGANSSPQAAESKTELNLNKAGECANGLCQKTSSTT
ALSAEGPGTFFTKLFDTSDFPARWYCGSWSSDVGWLHIISDIAIFAAYFAIPVVLLYFLL
QRKDLPFPKIIWLFAAFIMFCGFGHLIEAGIFWWPVYRFSGLIKACTAIVSLITVLVLIR
LVPEALKFPSAVLLAKDLQRSKERLDFALESGQIGVWEWNIKTDTLSWDRKTREIFDVDQ
EQSVLSFTDFSKRLHLEDRERVISRMKECTETRQTFNEQYRVIYDNGSVHYIQSQGRVVL
>A0A554X787|diguanylate cyclase|EC 2.7.7.65|Tepidimonas taiwanensis|TrEMBL
MTHPTMPAPADGDVASQLARDIDAAIAQHLAWTHRVLRCALLHQTPPGDICADNAHEQCE
LGKWLAHAPAPLQLHNAELLNEIRREHMAMHAAVAGLWAAGARTDPNRVQQALSGFERHQ
RHLVSALERLKTAVLSNLLTCDPLTQLPLRHRLPEQFGALRAQANRRGEAVYALLLDLDH
FKAINDTHGHAAGDAVLREVAQRLRACTRQGEPLLRYGGEEFLLLFTATDRAHAHRTADR
MLAAVSGQPVRYQGEEIAVSASAGLARHHDETGKSLENLLQRSDEALYRAKRAGRRRWME
SEIARPGRCDQARPPRQGRAPSVTA
>A0A128F8Y9|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MKKPELPVDETHRLQVLHHLNILDTGNEERFDRLTRLAKQMFGSKIAAISFIDINRQWVK
SGIGLETEYPRDISFCAHTILDSDPMVVNDTQADVRFSDNPLVLGEPNIRFYAGYPIRHV
SGSLLGTLSIADDEPRGFDDYDLRCMKDIVDLVENELASMQLTTQDHLTGLLNEHGFEVL
CQNSLNMCERLNAPASLAFFDVRGLKMINKLQGNVEGDRALVFFADLLKFGFRDSDVLAR
LESDKFAVLMTNTPIANTRDILDRFKERVDRYAVENRLPYTLDYYVGVSWAEPEADYDFG
HLVDVARNLAIKAKG
>A0A128F953|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MTFRKLNILLVVLTLSVGAILVFHNVRQAEYVREMNESWNQASVETMQIALDLAALERSF
GYVGFIHHFKNYVLRRDETYYFDATESYWQTVDALRRLMMSELPERDRLDLLVVQRTLNA
YFRKLNDLYLNRADLSAVDADRYVTVDDTKAREALVRLRADLIPNLQNQYYQTAASNQDN
AFWILLSSTYPLLIILAFAFSISVISRKVLMRAKEIDTIFNSSPDAFIYSNSNGQILRTN
KMATKIFGYSEEELREMRIEDLVDSALRDSHRKLREKFVSEKGSRVMGAGNSKITGLTKT
GRHVPLNVSISSFGFGRHKGIIAIARDMTTMNKLQLDSTHDALTGVFNRRHIEVRLDDEV
KRAKRYGRGLSVFIVDLDNFKGLNDSEGHRAGDRGLAVAAEHLRLQLRKHDHVGRWGGDE
FLVICPEISQTDATEIADRIRRRFEDLHFPWHCKLTMSIGIATLQPNSATITTQNLFDEA
DQALYVAKERGRNRVEHFAELQRPKRIK
>A0A2G2LDM2|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAVETLIEHHSQNFADHFYRVMQEDPHASLFLSNA
QVEQRLHPSMQRWLKAMFAVEHADFESLVEQQEKVGQVHARIEIPVNLVLNGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQDIATLPRLSNSDFGLWYLHKACHAFEGAPEIATIS
RHIKQVDCEWLEVLLHEDPSQRLKALGEIRDAARTVLMLLDDVLQRASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTVSVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A2H6ISU5|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MKKPLKEKQYTRSESDKQIEALKEQLSVFQNKLDEKERIINELMITDNLTKLYNREYLAT
VLEKEIARCQRYAHPLAVIMIDIDGLRNFNADHGTMAGDKMLSLTGNIIKENIRKFDRPF
RYGGEEFVVVLPETDMTMAYIVAERIRKNFESVCKKEFAPGQNGSYTVSTGITSVFAYTT
NTIEIEELIDQADNALARAKRKGGNISSRFEYVFPLS
>A0A6J4FML8|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MRLQTLVYGNTQFSPGSEYRKFQHRFACVLLLFGVVVTALFITATLFGGAQLHDYYLLAG
SIYCVVQGGAYLILRARPDRLPLVAPFGVTASFLLESVAFFFNTADELRIIWFALSVPAA
YVIMGRKAGLSLGILSVLFIVFANSRLQEPYSDNAIITGAVAILYIAAFFHAFSSKSISF
HHAMVEANQKLADMASKDPLTGLFNARAYYALCDQALNQARRSDQPLAMLFIDLDHFKRI
NDTHGHEAGDTVLKAVAACLLDGARRSDIIGRIGGEEFSMLLPDTDMVGGQGLAEKLRQD
VEALLPDIGGTSLKITASIGVAVARPHQRTVAEIQRDADECMYHAKRAGRNRVSTFEDGV
AA
>A0A6J4FFI5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MKLAHDMSFPTPHELDQLVDLCGDLLCLCRGSRIAWINRAGADLLGHAAADLIGRPFADL
LHEDHRTRLRKGLDPLAEPSCGAPLMLRAADGTWHTMRLSGRDLGDGVFAIAACALSGSV
PAVDSLVRSVHRLEERTRELSRIARRNDLSAQVFQTASEGIMVLDADLRITTVNPAFTQI
TGWLPSEVIGRKPPQLTQDGMDHPAGLLMYDSARTSGRWQGEQWNVRRDGERYAERVGIS
TIHDEEGELRQYVVVFSDITQRKLDEERIRKQANYDALTTLPNRALFLDRLAMAVSQGER
NGQMVGLMFIDLDGFKLVNDTLGHDMGDLLLQEAGRRLSGCIRSGDTVARLGGDEFTILM
PNLGTYQNAPLVAGRVLESLKKPFDLAGKEAFVSGSIGITVFPDDAGDAATMLKNADAAM
YRAKELGKANFQFFTADMNAAVEERLAIKNGLLRAIELDELALHFQPKQDLKTGAITGVE
ALLRWNAADLGVVSPAKFIPVMEESGLMGRIGEWAIDAACRHYRSWTDRSMMAPRIAINL
SVRQLRAPGFVEMVERILHRCGVGPEALEFEITEGMVAKDTKNAVALLNRLSGMGIRLSM
DDFGTGTSSLSVIRIFPVDSIKIDRAFIADLGTDPDCAAITRTIISMGHSLRRRIIAEGV
ETAEQVDALRDMGCDEIQGYVLAPPLPAAELERVLTTLGTGQPPDSP
>A0A8F9H8S7|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8F9HEH3|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A731YIN8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A376E0E9|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MTNIAYGATVALTLASGVVLMMASGADKAERAAVRQGAAYDSLTATVEQETYALTELARV
YVVERRPQDLAAWQAKKVQDDQDEAHLARLRDVGAGPEELEHLRQGMAVAHGLEDEQQQA
VDAVARGDNARALQLLFGVNYERELDRMDFQFAHFRSLLDQRTGATIQAATDASLRLRTL
SEIMVGLTALLFLFVLGFILKRRILQPVVKLSDVVNRLATQDYAVEAPLLQQVDEIGDMA
QAIHVFRENGLARQRLEQERDADWAIRRLLSRMTQRLQGSESRSDIIELARLFAPQIAPG
LAGRLYVLDARDHLMICAARWLEASGGDTAFTPDECWALRRGQTHSPGRDLVDIPCKHLP
PEAALRAICVPLIAQNETIGLLSFEKISEAQEPPYVYLELMAETLALALANQKLRDELTE
KAMFDSLTGLRNRYHLEDALHACISQAEATGSPVSCLMIDIDYFKTLNDQYGHDAGDAVL
KEVARTIRAVPGDTAQVFRYGGEEFLVLLPGLAQAQAHALATRMLTQVGELSLRYNGQEI
GPVSVSIGLATWPDHARRDNLVKNADIALYLAKEMGRSRIVVANRLKPTA
>A0A376EFB3|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MFNQAKLTGFREEKTLLNASLLFLLTTLFYFLGAMMRLVEPLSLFWPLNAVMAAVFARYP
FLNRPGYYAICYVAMLAYDAMTTSWGAASLLINFSNMVFIITVALLLVRDKRRGPALARP
VNALRLFNYCLVAALLCAFFGATGSLGVNAQGFLPLLCDWFSEQFSTGVLLMPWILTLTR
PSWPARIKPEALWPFLALVASLAASVVIGGAGCLAFPVAALIWCAVRYPLNVTCFLTLCT
GVLQIILVSAGIIEISSARLSVGSQMFSTRLGVATIAICPAIVAVSVSAINSLLAQISRR
ANYDHLTGVYSRSGLFEALARDDNNPALAGRPLCVMLMDLDHFKSINDNYGHECGDAVLA
TFGEKLRELTADAGRVARMGGEEFVIVCPDMTLDRACQLAETLRQRVAGETVVWEGQTLS
FSVSIGLGYDAAPRERVSDTFTRLMREADSLLYQSKRQGRNRTSVHDEHQPTLRLAQHLS
>A0A380AMU0|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MSNDQSAMNELHWLIDMVQTIEVGLVVLDRHYNIQLWNGFMENHSGVSPNSIKGQNLFTR
FPDLPDTWLKQKMESVFMLKNRAFISWEQRPYVFKFKNYRPITGRADFMYQNVTLLPLAS
LTGQITHISVIIYDVTDIAINKLQLKAANEQLQRLSQIDGLTQLYNRRYWQECLNHEYDL
HARYSDIASLVLLDIDNFKHINDSYGHLVGDKVIQHIAHLLSQSLRETDCAGRYGGEEFT
VILPKTSGADAIRFTERLREKIASSVITYENLKITVTVSLGACEIGSDITSSSNWILCAD
KALYEAKEKGRNCSVLYTSNQCSINIPNKNAHQ
>A0A5P9QEV4|diguanylate cyclase|EC 2.7.7.65|Luteimicrobium xylanilyticum|TrEMBL
MTHTPGSVAAPATPRASPVNPPDAAYERFARLLSAHLDVPIALVSLKRDDGHVGFPGAVG
LTGEYARTRVLAIEDSFCRQVLATGDPLVLPDVRATEQLDSPALQELDVAAYAGYPVIDT
SGATVGTLCAITHEPRAWTERELTVLADLAEACATQVRLRQESARARSAELAATRRHRNA
RTLLHVAEAMSATTTVDEVLDVAQGLVAERVGAVRGAVALADARGKVLRWVRHGDVPGLS
ESAWEGDLVSDEHWPSVRVLRSREPLWFETNRAVVEEFPRMPDAGGPGALAMLPLLTRDA
VLGVLLLRWPGRATFDHPFRDLLTTLAGYTAVALERARLLQHRRDVAHVLQTALLTDLPA
PDGVTLDGAYVPAVLGDQVGGDWYDALVLPSGDVAVTIGDVTGHDIDAAALMGQLRSLLR
GYLWRDDRTPAQTLSQLDAANVGTGVRANASVLLARLGAPDADGARTLTWSSAGHPPAFV
VRASGAVQRLEGPRDLILGVAPGAARHDHVVELRPGDTMVLYTDGLVERRGEDLHRGLDR
LAAVLAGGGPGAGAVAEPVAAAHDGAPRVVPVQVVRALVPGDLHDDDIAVLTLRVDPA
>K9NRB3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MTASRTPHFQGPSGRPEIMVIFGSTLTVISILCIVTFLLIREHAYAQQIATRSATTIAQL
IDADVLRTVELYDLTLQGLIAAAQRDDLKQVSPQIRHLALFDRSTTARYKGDILLLDKHG
DVLADSSLIEPKPGNFADRDYFLAHVFNRDTGMFISRPFKPRCDCDDSDQWRISFSRRIS
SPTGEFLGVAVASMRMSYFDQLFNSLDIGTGSTLGIINNDGILLAQKPYREPHSIGKSFS
SRPNVVRMLQERNGTFESVSSVDHQRRLYTFTRVGNLPLTVIVALSVDEVFATWNRTAYV
ISGATGVLCIGLLWLTWLLCRELRLRQSAEQELSQLAATDALTGVANRRSLDQTLRHEWF
RAQRSGKPLSLLMIDADHFKAFNDRHGHQAGDEALRALAEVISANVHRPTDLVARYGGEE
FSVVLAETGGDGARQIAEHIREAVQKLPLVDAGERPMSVSIGIATWTAASEITLEQLLFS
ADKALYQAKERGRNRVVCAK
>K9NLZ9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MPTRFNNPDHAPGVALKRIPLRKAAVLFIATVCLCLCGLLYLQLEQSRRHDLSLAQVASS
NLTRAMAQQAEDTFMKADLVLTSLVDWIQVDGFGQDMRPRLQQTFARRVLALDQLHGILL
FDQKGQWVVTSFENLPRGTGVADREYFKYHQQNVSSVAHIGPAIRSRENGEWIIPVSKRV
NDRNGHFQGVLLAGIKMSYFDQFFKSFSLDDNGSMFLGLTDGTLLARRPFVEAQIGVSLA
QGEIFQKFLPQANSGNVMFTSIIDGVTRLYGYRQLEAYPLVVAAASSTQTILADWYDTAY
RSSLIVALVLLGVGLFGWVFIRQVRVGERVESDLRRAQQALELIATHDSLTGLANRRLFE
RAMDIEFGRGARQASSLSLIMLDIDYFKRYNDTYGHVVGDHCLAEVARALKSCCHRKADL
AVRYGGEEFAVLLPDTDIHGAMTIAEQIRRSVIDKNITHTGSPNGYVTVSLGCYSFVPSG
LDSMDVFVERADAALYQAKHSGRNRVATLSMAGGGEALMRSDR
>A0A518EST9|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Poly30|TrEMBL
MSNTATLSFSRTGRGLFTRDEVRALMQIEFERAERYSYPIACMLIQVDHLAQIQTVHGHE
AKEEVLFSIIDLVKGATRAGDLLGYIVDDRLMAVVPHTHPVAAKALAERLLKGARELAFA
LEGRTIRITLSIGLSHNQDPGAKSFATLERVSEEGLDVADNGGGDRCVQTELYQLYEREK
KPVSREDIEDLLARAEKMGYRQRLESLVQGGADLEVAAETVAEEIIDRAVDAARQDWEKE
LAEANAEVVRLSAESLKSPAGSPDEDLRREVEQLHRRIAKLTGSLEMTEQEIARLRKLKN
VDDGVASLYRDVQGLGDGDARSEVKKELMGEIFRANMHLQGKKVG
>A0A2X4WQG1|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MFEPCFPENEAERLSVLNSLNVLDTNSVEKLDRITRLAAKYFGVSIALISLIDRDRQWFL
SRFGLDARETPRNISFCGHAILQRETLVVPDTAVDPRFFDNPLVTGGPKIGFYAGQPLLS
LDGLPLGTLCIIDSRPQSFSHDRAHDLRDFAAVIEEHLHGVERDIYTESLKSNLQRTEAL
FEQTFSQAAVGMALVSLEGYWLRVNPRICEMLQYSERELLERTFQDITHPDDLHIDLGLL
KQLLANEIATYSMEKRYYRADGSIIWVQLTVALNRLPNGSPHHFISVIVDISERKAAEAD
LFALQHELEERVELRTHELSVVVNKLNLEIDSRVLTEHQLSAEKERLRAITDNMPALISQ
IDNEERYLFANSAYKTWFGLDEARLKEMTVRELIGEAAYATAKPVIERALCGETLSFENE
LQTRQGLLMIHTTLVPCETQGFYILSMDITELKRLQQRLEYDVTHDMLTGLTNRRAFLRR
LAGTLQRCCPQQQMALLFIDLDGFKAINDTFGHDFGDLILKTFAKLLSACAGTNNSASRL
AGDEFTVILWPLMDPERQVTEFCEKVLTQLAAITQIGNQKVTLSASIGAAISSDGTLSAE
ALLSKADDAMYQAKSAGKKTYTIR
>A0A399FDQ8|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MLSSAWHPPRLEARALRVRLKPANMRIFLGLLASLLGFVAVHLFRWGDQYGLPWLMVIVA
ILTSLYGRGWGGLAAVLALALDGWLGGARHLGWSAVLLGITFVIADLIGRDLRRAYLRQQ
ETAAQLSLLVAALEELSGLGSQVAILRALPELLGRHGEGHVSVWQPQPGGMGLVSAVGLD
PSAPSLLPERGVVARCARQGQRVYLGDVRQDSDYIALPNSNIQSELALPLLERGQVIAVL
NLERPGPFSPRELEGFEHFAQAVSTQLTQLSERGELQFLNQLSTSLDSATTPVGVAERAL
ALLVGALGLEQGWLWMQQGTRMVALAVYGGETPLTEIPYAQGLVWEVYHTGRPTYAQDYS
ENPRAIPEFRQAFGGVVAHPVFLSNQERPRVVLSLQQKSPRMWREAEQDLLAAACRTLGL
ALDGALAAQQRDELIALSHEAAEAPVEEVYRKILETAVRLVPGAEAGSLLVREGATFRFK
ALLGFDPSLKSHVFSEAEQFHWYAGSAQDWYRGEPRVLSSAHTDLKQFSNEEILVSGRIE
EIASNLALPVVYRGEVLAILYLDNLHDPAAFGEDSLTVARFFATPIAALLHEVRYRGLLE
RAAATDALTGLLNRRAFDHRLEEELGRAQRYGHPLGLLVMDLRGFKRINDSLGHAKGDEA
LVRVAEVLERSKRDGDVLFRWGGDEFAVLLSNTNLAGATAAAQRYAAAIESVCMEGLALG
VNIGAAAYPADAKDGDTLLQRADQRMYQAKSSGVSVMAL
>A0A399FAC9|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MGPVNPEKLRDEDLRLAQLLEQALSQAQTHGGPVSLLEEALRLAQERNLLLLKSRSTLLD
EVTPGELDELTHLPNAKAFSTALERALAEEGDFSVVFFSIDQFDQLSNLFSAALADEVVL
RVAGLVTRALRRGDVAGRLEDGSFGLILRGATGDRAFGVCERLRMAVFKQDWNTLHPGLK
VTLSLGHTGRSGHRSASEVLARARLLQAEASSSGQNQTFPGSYY
>A0A509BQS7|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 6947|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGLTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A173U772|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MRSLQSKFLALTVGCVLLSALALGYVGFLYTHKLVNEDSAQFMNLFCEDKAEEINATLTS
IEQSVNMIQDYTIEQYSELGKNGMDKDNTDVLVKKVQEVALHTVKNTEGSRGVYMRVNPE
LAGPQTGFFWYKDENGEVTEDSLVDFSKYAQDDKEHVNWYYEALEKEEAFWMEPYDNKNK
NDWIISYVVPIYRNEDFIGVLGMDIDMALLKEKVDSVQIYESGYAFLAGADYVIYYHRDY
PEGLDEENTHGKIRKVLNLLYKKGTQDNLVGYNLDGIKKKMTARQLENGMFFVVTAPAKE
INASSNRIIRLFLVSTLSIIFISVLITIHVTREMTRPLKELTEAAQKVAGGNLEVNIDCE
SKDEVGVLADSVQQMVNHLRHYIDYVNEQAYTDALTGVANKAAYKEYVDKLDKRAADEKI
KYAVVVMDINNLKKINDNFGHEFGDMLIRDASRLIQKGFKDHIVYRIGGDEFVIIIEQAE
KAICDELLRNFDDGIVVFNKNNTKYEQKIQIARGIAFYEPDCIDSFASVFREADHAMYEN
KVMQKSMQTAPPAAGQS
>A0A5E4RPQ3|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MALLLDAVFLVDKAGVLVYVSPACERILGYSPEELLGRSMIDFVVKEDRERTIEESKLVM
AGHPRIGFENRYIHKDGHFVHIMWSARWSEDHELRIGVARDVSAKKQAEALQRATYSISE
AAHDAADIRSLCKAVHDTLSKLFPIDAIVVATCDADLMAWEKAYQYRDSADVPLLDWPQA
RGLSTQAAQAQQTLWHRIEAVPIDGAGQSISHVRAEPFVPDALVKPGAQALAVLPMHTAR
RAVGTLMLYGPASALQAESAQRLLSFVCDQTALAIERKQLIDDLYKAARFDELTGLPNRR
TFGEFASEAVRRAQRTNGKLALLFADIDGFKGVNDSLGHAVGDLLLKEIGQRMKAGVTGC
GFVARHSGDEFVAIVQDAEVVERIDVAVTRLRAEIEQVISVNDASLSVRVSVGVAVFPDD
GESMSELIRVADQRMYANKSARKSGGASFLQRLI
>A0A730Y807|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8G0SW24|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MPHAKKGLRLDLRTLILVLSALTAVTMLLTSYFASYRVQRQLLIDHSLEANRVYAAKLAA
ITDTFLGNALQQLGFSAGVQAHNLNDAPSLLAETERVLQQSIAFNSTFLVDAQGFLRAVS
PAPLRHLIGTHVQTPGSQEALRERRPLVSTPFLSAANNLVVVLSQPIFDGQGKYLGYVGG
SVYLRERNFLNSMLGEHYYKDGSYLYVVDRNRRLLYHPDPERVGTVVEGNSLIDQLPALS
EGTRQIHNSAGVEMLAGFATVPSTGWGVIAQQPLSQTVAPMRQLILNVVLLSAPLALLGF
LALWWFALAITRPLWQLAAGALALDRPGTAEHLHKVRAWYFEAAELKRALLFGLNLLQER
IGRLNRDAQTDPLTGLGNRRSLEYNLSLLKAEERNFAAVVLDIDHFKRINDTYGHAVGDQ
ALRQLAELMRSCCREVDVLCRTGGEEFIMILPGASLEIATVVAQRLRICVQDTPLAAVGA
ITVSLGVAHWQANSGSLPAEVLSEADAALYVAKQNGRNQVQVARSGEAAHS
>A0A0B0HNN0|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus sp. BCO1|TrEMBL
MNKKLSSLFETDTFLSIAHTIIQEADEGMIVTDEQGRILLANPAFETVTGYTQEEVLGKK
PNILRSGLHDRKFYENMWETLRDHGVWKGEIWNKRKNGELFVEWLTIKAVYDATGTPTHY
VAIFSDVTQHKRTMEQLARLSNYDVLTNVPNRQLFTKRLQHLLDVARRYNQQLAILFLDL
DRFKYINDELGHYSGDILLKKVANRLKKLLRTKDTLARIGGDEFVVILPKLKDVQEAITV
AEQMIEALQAPFMMNGKDVYISASIGISMYKRWG
>A0A1A8TJX1|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MAEVTGHLRKSLRIRITAAVLIMVLLMLCTGGLCFFYFLKLSESVKLQSDRELPALQVLN
GAQLSITRLSNLANEVANSTSPAYSRILMSQVRDEISELQNSLLKLTDRNEQITRLTEIV
AKVEPSVTSMSMSKAMLDQVEAALQEQVTRALRQVVQTHKGARQAAVEETLDELLLELNH
LLSAKHLYEQNQIVFTLKEQLTQLNRIAPMIHAQLSPLLSSPKGVFDLLAQREQHRSEVV
GLSTQNKILLGNVVDFGHRVYMDMEANVAQQAEQLSENAQSFIDGLVLAFAVQLLVALSL
LGYLHRQLFRRLQALKGLVGQKRTITDEDVAFFDAQNELGSLVKKLQSYMNTITTQQAQI
ETTSQQLQTIIKHSHMKIAVLIDGQLQYCSDALKQLFANRALTSLESFPDDVVNHIKAVL
ENQANTEEGAFWDVESQSWYDITRDTIIWQNQHADLISFADVTEQIQAQQEFKRTLSEVE
NEAQIDPLTGLLNRKTFDTTVMNASHEEMLSHFAILLFDVDFFKEYNDQLGHLQGDNVLK
MVAAVIQRNTPSEGAAIRYGGEELLVYLPDTQVKTALDIAQTIVEDIFSQDVPHPASPHR
YLSVSCGVSMQTQATESVLQVFDQADKSLYKAKRSGRNCVMLWSDTKAEQDLL
>A0A1A8T2E6|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MPQRTGSLLIPLFILLAGLFASVYTRVLPSLALDLLPWLPYVLASVMVFMAWHFNRGKVL
LAGGLILLPAFYPYVENESLPSSFTTVAAIGLGLLLVLRERGFFNRFVFNRILFLGMLVA
WSVSYEKNVINFNFLAVNVPLLQISLSALLCWLMIALTSLLSLITWWRKADGFSTAVLVS
LVTLLLVECMTFSAHQESAVRSAQILVWVWFVVAESHRMAYRDELTQLPSRRALNEAMLA
LPRHYAIAMLDVDHFKKFNDSYGHAKGDDVLKQVARVMQRYGNSAAIYRYGGEEFTLLFK
GRGVEHAQALLDQIREDVQAEQLDVSTETKEKTVSVTVSIGLALGQTSDAPSEVIKRADQ
ALYQAKKKGRNRVVLAA
>A0A239RPE2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MGSLLLICHFAFRAPSYLLWLGLGYIVPSFSVAAQSFMSNKQLALSAPILGSMYLFGAWA
SAYAMGLRKNANARPYWCLALVVMALLSLSYYSYVDDQLWIRMLILNISIALVEFLVLFS
MFKHYQGIDLLNKIVDFSYLFIVLYTFVRGIIIFLFLRNIEVDMLANSVWWLMMLAASII
LSMWFAIVLLGTLVRDIIHQLNDERLRDPLTHLFNRRGFNEAAKRKLHQLSKQSYFLLMC
DIDHFKKINDTYGHLVGDQILQQVGQIIGQNVCDHDLVGRFGGEEFIVLLQIDDPTLAYN
IANRIRLGIADAQLSSKSIAVTASFGLAAVHQPNLKYAIHTADQLLYQAKHSGRNQIGFE
PAQSILDASH
>A0A087A1U9|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium biavatii DSM 23969|TrEMBL
MLGGMNKPIEASIVVVDDEPSIRELLVASLHFAGFEVATAASGSEAIEVIEKTQPDLIVL
DVMLPDIDGFTVTRRIRQEGIGAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVA
RIRAILRRTREQIEDDPIIRVGDLEINEDSHDVSRAGQPIDLSPTEYKLLRYLMDNEGRV
LSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDGITYTDANGEKRKVTPLIETKRGIGY
MIREPKTAPGA
>A0A0Q0IZ22|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MTIGFIDFDNFKSINDTYGHQAGDEVLKGFSKIAQTFLRREDLIFRFGGEEFVIVFQGVN
VIDAKNALVRLQSGVKTMFINHGNKALNFTFSAGVVELHKKLPIKDVIKQADKLLYKAKK
EGKSRIEY
>A0A375G3D2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MQQIPPPPGQPLSLLVCDLDFFKFINDNYGHSAGDAVLAQFGQIIAGGIRRRDIAARLGG
EEFVVLLPDTAPDAALQLAERLRHTLEHTPMTVLPGVHRVTASFGVATLRPGEDLDTLLM
RADHVLYAAKNRGRNCVAWERDEALQAPGALA
>A0A5I6QFL9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kiambu|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4P7LG83|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MWRRLLPQPRWLPRLAVMRPQRVVLACFGAVFLVTLVVAARELYLVRERVIGERQHALVL
RALGVDAILSAERRRLFFLRDFSEYLFALYANVGTADADIERAYAARNDDAWQLPLQRGD
APLIGVGPRSLAGLQGFARRDADLKADLMVGRTLSQLLGLGLRGDLIQGNALFISSNGFF
AIYPPQDPAKAVRLMQRFDSMDYYRGHMPARNPTRSIHWAPLYTEFEGSRVLTTISIPVY
AGSQFRGVIAVDVAQQRLHELLGAASEPGTVHYMVNVHGDVVSSSGSGFTGLRKWPEAIA
GDWSGHGVAELFARGSGMLGHNGDLLFFQRAGQSPWLVVDVLPLSSLAPAMFSRLSGPLL
IVWLLLPLLLWVTMRVVTQLFDHYLALGEKLQELAQQDPLTGLANRRHFRASFGREARRQ
QRGGTALSVLLIDIDFFKKVNDRWGHASGDRVLGALAQALHGTLRGFDLPARLGGEEFAV
MLPQTGLADAVRIAERLREAIAGCAVAAEPEAEPESDPALHAADAGTSGPERVIRFTVSI
GVAESPADAPLALDALLAIADRRLYDAKTHGRNRVVSDDGLHAGEADISERST
>A0A0U1KA15|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPKTPAVTLPIVMITVFSLSAAAY
LVFISKKYADKLNLFSIILGLLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FIAFCLHTAPATLTVIFLDDFQNIFRIIFTLMLPLIGFSLHHLMSRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVAFAGKKFSSAESSP
>A0A5P9F3P7|diguanylate cyclase|EC 2.7.7.65|Microbulbifer sp. THAF38|TrEMBL
MNSGYKKHNPSLNTPVEELERIDLRRRIMASSYMLIFAMAVTGAMAVIALSATDILQATT
LSAAAVVILCAYVTINVMGPSQKTPLLVGILLLVLYFYLLLSGGVNNTGLMWAVMLVPGF
INLYGYKTGTVALIAIGLVTAMALFYPDFPGLKAEYDTAYRARFIAVFGALTALTALLDS
SRHHTQELLERLTGELEKSASTDALTGLANRREAYRAIHDMERRNKELQGQYVLLIGDLD
NFKGINDTYGHGFGDRILQDVAKILKENTRTEDIVARWGGEEFLLLLPNTDVRGGSVLAE
KLRRKVEALSRRYVQPVKVSISFGVVEGSGNPHNQLLAEADRRMYQAKNSGRNRVVAA
>A0A174D1J2|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MPFPIYLGWGLLVPVVLSLLFACLSEHAMSTLGYKQKNTVLKRILNYLPAFLLFFFWGMV
NIPLPLFYILAYGGKLSRLLRNSRYRSQELFLINLTHLTTMALHMILVGTISLATGIQMN
ELLQQPSWRIATAGVVLAANSLTAWLIPRWGMILEVLRTQSESEEVRPFMIFLWFCNIFL
LLDSVLCIADISWGLLPLFLVGSTLLLEFYLIRFLSHFYRILKVHYLEEEHHHLMERLEE
QNRTAAELRSKIVLDSMTGIFTRRYATERIGFLLQEKEPFSLVFIDLDLLKQINDREGHH
AGDLYLIRFAKELSSCLRKADVFARVGGDEFIVMLPGCSLEAAEKRMKSIRIHMEEQCRP
SFSFSYGIAFVTDNYNGSVEQILHRADQAMYLDKQKRNGSERRE
>A0A5P9F046|diguanylate cyclase|EC 2.7.7.65|Microbulbifer sp. THAF38|TrEMBL
MKDRIIRQRLLNFWHAVFKSWYFRPALCVFLLLFVYTVFLSNASVWAHAPLDVTVSEKGE
KSTGLHAIWHDERGESDIYTARQANELGEFRTLETAGSTGLSAGVFWSHFTLRNRDSQPT
TLHIEYVDHQLVGLQAFSREAASGDLYHEISHLSIYEPFASRQVAHNRFVFPITIAPGVT
QELMVRFDVGDLGVAFPSLRIWSPQALQQNSKGETSLIAFLFGGYFLMALFALVGAIAIK
EKILYIYSFYCASKILVWGTVLGYTHQYLMTASSHWGYASLSGAVAIMAGLVFARTFLET
RQFTPKLDVLLQLMMLNAAFLIGCVLLELKALSQISMIIALLCYPIVVPIAMTRWRQGEN
AAGVFALGWATLVLGLLVQAMRDLGFVVHNPVNYYWPPVASFVEMLAIMGAIGLMVQRLR
LQKDRAEKKYLQQLEISKSDLEELVQSRTRELEAAKTRAELEARTDPLTGIHNRRSFFEE
SNRLLKLAQRKGISLGILMLDIDRFKSINDRHGHLIGDQALCATARVISQHVREVDVFGR
IGGEEFALLVSADGPGTLVIAERIHRDIAKIMIKSAQGPVQFTASIGVAQLRGQGDVLEL
LQHADNALYRAKRSGRNRVLEYETVES
>A0A7W3H6G6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICTALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A7D6XT85|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHVESALFL
NTEQVSTRLSGSMFDWLRSVLGSAQEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPGYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGDLVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESAIAEIDGRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALQARKPFTLAMLDIDYFKQINDNYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILDTLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A381GST3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MNDESFYQKKVVPHEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVLVAQPI
TGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNFKADAILAGMWIGIMGINLLPSTA
LLMIICINLMGAGGMRIFIAGAVLMTVSCLVTLQLTDISVAFSSTQLSVLLTLPVLVIYP
LLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQRDATLL
IIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPATSA
IAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAEIEHYREWVKAADMALYKAKSSGRN
RTEAAA
>A0A8B6LGK7|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SRS16|TrEMBL
MRLTLRTKTALLTTFVVLLLVGATGVWQYRRLSDEYVALMRAQQDALTRIAAADLDYKLS
MHLSVLGRAARQLDARSFADSSAQQRFFAGSGLRPMFDSAALVATDGEVVVNDPPIDRPL
NLADRDYFRRARDTATPTISAPLLSRITRQPVILMTVPVKDDDGRVAGFLSAALSLDRAN
VLGELAHASVGQGGYYAIVTRGANPVFVMHPDPRMLLQPVALPSTHLGDDASRDLTTSAP
IDSTDWELRVVVPAKTAYAPLREARRALELQMLWLGVGCGVLVWIGTAWLMRPLAILYAA
IRELRRSPDSAVKLDVRANDERGDLAREFDALMSELRDKRTEIAAVTDASPLGLFRSDTE
GRMVYVNDAYLDIQGLVRSEMAEGWLKLVPDAIRATVREDWMRIVRKAQPFQTTRWLRRR
DGTEVLVSLSMRPIMTPAGVAGHVGTLSDITERTRADQALRTLTAIFEATTDYVVQLDAK
GRLTYMNPAARRRTGIAPDTPIEHLVMEDFTPPESLVRMHDEIVPAARAHGVWVGESLTW
DAEHRLFPVSHMVIAHRDRHGKVERFSAIMRDISAAKETERELLQSEARLRTVADALPMR
VAYIDEDQRYRFVNLAYEAGFGLPRDAIQGRSVRELLGDAAYRTVEPHIRAVLSGQRVTF
QSESAQADNDLCFEANYIPQLAAGGDAVDGFHAVIIDITERKREERRLVRLARIDPLTGL
GNRAAFEERLVEAMDHSRLDGALLALMYLDIDHFKRINDSWGHPVGDALLRAFATRLVQA
VRSGDFVARLGGDEFVVLMEALPRLEAAALVAEQILQAMRSLFMFGDRALQVSASIGVAF
HRGEVTTADALVRRADEMLYRAKGAGRDNCQLAEVPGSPDI
>A0A8B6LH99|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SRS16|TrEMBL
MRARPAGEEFCVLLPDQGEALVRTLADRLRILLAAVPRPDGRLTVSAGVAGMRVDESVLQ
TLHRADLAMLKAKQSGRDAVCVADEIH
>A0A239STE0|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MKSTISRTEQGNRVAATTILAACAALTLAGFLARTLEGTVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGISTHVTRAPFWLWLVAEA
SFAAYVMLSVRSYSRTRMDPHTRPGYSEAARYGATVLIIWVTVSLSIVGAGRTLVTPHLT
GGIDIETIALSALFIAYIALWWRIAAVTRLSHKLFLLVWVVVSISLCQLLLSLTAPSEAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRLVAERVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDAVLQRIATTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPQAARDEGEAITISVGIASWQP
GEPLVISAMLDQADKALYQAKHKGRDQSVMGQMAA
>A0A239SKK9|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MATNQAPTLDSLQSLLATVQRNERSLKRFQDIELALMGAPDFGQFLEVVLNRLRHDFDLS
GVRLMLAEVDDTLRDLIDTAEGIRALDGGLCIAQDTGTFSAVCGNGQLWIGAPRERHSAL
FGARAPASAVVMPLARNGRYIGVIALGSRDARRFAPDMATDFLERFGAVVAVCLENMWNR
ERLKRIGLTDPLTGLSNRRYFDQRLREEVIRGARYGAPLACLLIDIDHFKRVNDSHGHAT
GDRALRAASVCMRAQLRVTDTLARYGGEEFAALLVQTEQNWAGTVAERVRRAVARLEVPD
DDGILVPLTISIGLASVDPRDIADPESLPMRLLGAADAALYAAKRSGRDRVVVAPTASLR
>A0A2E9DDL8|diguanylate cyclase|EC 2.7.7.65|Oceanospirillaceae bacterium|TrEMBL
MPLTDLDALIEEWNAKLDAFPLELHQFVEQCAQTHKETLATYFYQQMLADRDAATFLSHE
QVKTRLHGSMQRWIVGLFQGPETVNVREVIQQQVHVGDVHARISIPVHLVLRGARALKAR
FVHLLHDTPAASPELIALASRRICDTIDLAMEIMSHAYASSHDRKSRAEEAYRMFAVAQN
ISSEKERQRAALLDWENQLMFDKAIGLQPEQLPRVGSSEFGLWFRHKGAHAFEGSHEARL
ILDSMERIDNVLLPAFGKPLSEVSGTYVDQLRELREQSKSMVYHLDRLFEQNTVIESGRD
VLTQLLNRKFLPVVLNKQVSYAREKNQGFAILAFDIDHFKSINDNYGHDAGDQVLQQFSS
LLINNSRGGDFLFRMGGEEFMMLLADVLPGDALRTAEKLRERVAAEPFRLDDNLQINITC
SVGLAMFNGHPDYQQMLQRADAALYQAKSAGRNCTVSADH
>A0A8F7LKM9|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MAARTPADIARDTLKLLATRRLAPTPANYQAVYEEVAGLLPQVSFPLTPLRRIATVLPTQ
TPVQKRLAHAFSTAVEAQDWTALQTVIADYAQLDLGIAPKAPVLQEAPTAITTVNVLPDT
LAQQLARLIETTVTALGEEDQRMQELSEQLVHFLRTAPPPLATLEQRLHNYSYRLSFTAQ
DQAQRRMGMHALLRMVCEHIASLAAHDPTLQQQAQALATAMEQPWTLQQLDRIQTHLKSL
LFRHLEIEGSRADAHEQLKSLLAEHAKQMASLGKLSESHAQALTNCAQQIQQAQDLGDLT
PVLQAVVHSGSALATENRIVQAQLADLRAQTQAQEEQIEALSNALLGVEDSTRNDPETGA
LNAQGLQEALLTEAARNQRQAQPTTLAALHIDQLAALEAENGPQAKAAALVHLARLVRAT
LRPQDAIGRIREQQFVILFPATVVTQAAQALARLQQELSQRPLLLDDRAVPLSFSAGVIA
LSGLDTPAEAVQRASQACEQAQRMGLGRVALI
>A0A011QDJ2|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MFKHDHLSQLHSSRLASRRLHRRPAIPGGHPSAHAQTSGAAAGSGTQHRRMRYGSMPAPQ
ATILDLLAAEARIADLESALSKAQAAAVTDTLTGALNRRGFDQAYEREAARTRRKGGPLA
LALIDLDDFKRLNDTLGHQMGDQALIHLVRTLRSALRPSDILGRFGGEEFVLMLPDTGLD
EAVTALTRFQRQLADCSLAGSDVALSFSAGVVVQAPGESLLQSIARADAATYAAKRAGKN
CVLTG
>A0A6A5BB07|diguanylate cyclase|EC 2.7.7.65|Pantoea dispersa 625|TrEMBL
MPISPLSSRRMTPALRVHLCFLAVFLFSLFLTVHEALELKNNYQQRQRAQLSEIQRSLDS
RFQESLDELNYYQRMLSYALTHPLNADYGQHALQRFQQLRHQPVWQLQIANLRSMPINGV
SDEWLQRDALLQRDDTYLLPELRAALEFSFIMQFSDEAQDFHSRFWYTSRAGYYISSRPP
RDAQELAQSYATMTQRPYFRDQRPGRAPQTRWHWTEVYQGEFNEGLMLTVSAPVIAHQHW
YGVLSMDFTQQRINALLQQSRHSVLQGKLVLEDRALNEITRLPAPHDVALTPAQRGQLMQ
AIHQQPAGTLWLGSQLASWVKLKNVDACLINVQSLRQGLAQELGRVALFLLGMWLLFVLL
LALAHQVIFRLVRRLEDLSARLAWRANYDGLTRLLNRSAFFDQFIALARRCEQQQQPLAV
IQLDIDHFKKVNDSWGHHAGDQALMRVAGVIKHTLRPYDVAGRIGGEEFCIVLPHTTLAE
AQGVAERIRSRLAAKTILVNASTTFSVTLSAGVSCSTEQGSYHAESLQAVADHRLYLAKS
GGRNRVCAAG
>A0A3G8GXM4|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pauculus|TrEMBL
MTWRKMLPRPRWLPRAALMHPQRVVVVGFGLAMLMMLIVGARDLYQLRERVLSLRQHELT
LRALGVEAVFAAERSKLTFVRDYAQQLISIHEAGLAEPDPAVERAFAARNTPVWQMDVPL
GDAPVVGVAPALLEPLEGFERRDADLRADLYAARQLSHVLGLSLHSTEDRDGTVTFISSN
GLYVTYPPRGPDKAPALFQRFSNIAYYRELLPAHDASQDLRWTRLYTQFESTELRTTLSI
PVYVSGRFRGVVAVDVKLPRLRALIGTPEEAQVSRLLMDRRGAIIAASQHSMRVDMRWPE
DVDPAWRRVPPQDLFDKGAGRRHADDAYLLYQPVGDQGNWMLLETLSDTDLARAVMQRIS
VPLLAIWLALPLLMFVTLRVVTLLFNHYLAAGEKMQRLAETDPLTQLANRRHYSEQYGKA
AARRRRDGSPLAMLMLDIDFFKRVNDRWGHASGDLVLVALAGALRANLREPDLPARLGGE
EFAVLLPDTTLAQATETAERLRRVVEATVVAPAADAPPQADGDGRIRFTVSIGVAEAGTD
ACPTLDAMLATADRRLYAAKQAGRNRVCAADAPAGNAPVPPVQG
>A0A7M2V1U5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. BDA59-3|TrEMBL
MGQEKVVKSPPRLAFVRTWFVPSRVVNLCFVIVLVCSTVLTWREVIVMRGAYVVSQRNAL
DNVANVLDRQMQVGIDRLLFFRNGMQSAVQTPLAFDVLRNIQAEFEKERILPYWQIGLDN
RRTLPLYGVSDYFVDQSALLSRDNPLLHNELTAAMELGYLFRFSSSASMFPRRALYVSRA
GFFISTLPVGNNNEIVQQYYQHLTSPWFSGQSERENKLRGVRWFSDEAHTPNIADSLVTA
SVPLDFQNYWYGVLSMSFPVSSMKALLTEARQSQDKGEYQLYDAQFTLLTTTADAGTTSQ
QFSPDEHAQLQREMARDTAGGLRLGTRFVSWERMKHFEGSVLRIQTLNEGLRSDFGSISI
ALALLWLLFTTMLLLSWGVIRRMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERAQVLT
TECAAQNLPLSVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEE
FCVLLPGATLADATAVAEKIRQRISSKEIFVQKSKTIRVTASLGVSSALESGNYDFEYLQ
SVADSRLYHAKNNGRNQVCAEDGVTPLPNT
>A0A2Z5K2B2|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. Go-475|TrEMBL
METESEPYVRLASLRQLHQVMADMNTARSLADTLQTVAEGVVAALGYELACVNLVRPDGD
LVVAAFAGNPAAEALITGRVGSRDSWERRLGMGEHWGDLVFIPHTEGWVLDDDDVPQWYT
DGPAPRFEDEWHPADRLFAPMYAPAPKGSGTCGELIGVLSVDRPRNGRRPGAWGREALQM
YAFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQH
GRILRTNDALCRLLGRPASAMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYV
WVSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRSRLSA
RLCQRATPHAAVAESHDAAYGHPAFDVVGPGFDYRQSAEPYDAYDHHVHTVAPDGDHDDG
TKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLSNGVRDGDTVARLGGDEFVILAD
GLGRADAQDLAVRLRNEIIQPIRAEGRAVRVGASFGIGWAHCGMTADEVLKSADERMYVE
KRSRPKQHRRAG
>A0A5Y2SE82|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPRAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0Q0L035|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MILFYSVMSLFMSFTLHADTIEIPSFSKGSVGKHTAYFRERDGKLSLTEARQQFQTTELS
LGSSNSISLGIGVDPVWMSVKVNNVANTSQDYRLSVETPWIDYIDTWLIKDGQVIKHIAG
GDAFSFDTRPMQYRFYAFEHAYLPGVTDIIMRVETKGPMALPVQFNSVENAINRDIVSGY
QYGALYGIMVALALYNLVLFVFIRQREYGLYGLYLLGFVLNSLSYTGQLHTIITYDFGPY
FQDWLDIFLMITYSVAGLHFARSLLHTKEYAPRLDKFVLRTTLYIPLGMLIGFVFNQLFF
SMVLAFILNTCFVMLFIAMGVKALQAQKPFAVLFILSSVTAAVCITISTLAVAGVLVPYN
DYTFKAIEVGMAFEAILLASILARQFRIAQIDKLIAEKYARTDPLTELNNRRGFKVLTEL
TWPNIVDTQRNISVALIDIDFFKKVNDEYGHSKGDEVLKKVAKAIAETSREGDISARWGG
EEFIVFLPDTTRDGAIMHAERIREAIEAISFTGIDCELMLTASIGVAGSVAARFEDESIN
HDTLEVMIKNADRALYIAKQDGKNQVRVVS
>A0A174AB40|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKKNQTQIKKYAAVISIFLAAVIVGLFVFFFCIKRSVEQRSKNTMRNNVVRQSEHLRTIL
DIQYDYLNALAEEIGKTDHLLAKKNMDLIKSITKHTDFGGTALIEPNGDAHYDNGLIKNL
SHRKYFKEVISGKRTLSDPLDSSISGSTRVVLGVPIYNSKHKVIGALGGSYDVTALSRML
FEDLFNGQGCSMIIAQNGEIIAFEGDTSYWNLDYRDNFYKCCCKWIIKDKVTVKKIKQDF
KEGKENLVTADSKKEGTRRHYFAYMPMGVNGWILCYALPEQAAQQSYNFIEDYEISFMIV
FIVLVTLLILYIVYENHTRNKELLKYAQTDALTGLYNKETTEQLTDELLSEDENKYHAFL
ILDVDCFKQINDIYGHAVGDIVLQKFGKLLKGTFREGDILGRIGGDEFGVIMKNIQTKDI
AMKKAEELLAKTQAYKIDELKGNNISISIGISTAPQDGDCYMDLYKRADQALYQAKRSGK
ARVCNYFS
>A0A379R9H4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEILINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A402SHW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3X4UL35|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A378ECP0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
KRAAVAQFVTRSVDRPG
>A0A157PM15|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MLCAHLLCFSIMFMLISRRLPGNRMGMDYFAAGNLLLAAAYILQLLEGGPAWSAMSVINH
ILTLASPIAYWLGAMRFFGRSVPLWRPLILFAILYGVMQCAVQWGAGPTARYAMLAAMAT
LLFLVMSLTVIYGVHTFARNFYGEMVFFAILIAGIGILNAMKFMKIVDGGLDVLHMDSHF
QTIFYIYMSTLATIVPPSIVWLVLRRLTDDLRSMAARDPLTDLFNRRGLLEAVQLYFNVR
HARPAHLLMLDIDHFKLINDTHGHQAGDEVIGHVADLLRATARRGDLIGRIGGEEFVVIC
LETDEAGVLSLAERLRAGVQAQPFTVSRGSQPLRCTITLGISPPFLGAHGLEDALQRADA
ALYRGKAAGRNRIELALAHDAPPDGNATRTLAPA
>A0A3I8FPW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A157Q2M3|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MSSESLYAHLASKVNLRKLVTSLALLSALVAVLNTFVASYRVQRHQLMHATLEANRTYAA
KLAQSTDSFLKSALRELQVSAGVIAGLISDEEALQKEAHRVRLQNESFNSVVVVDDTGLV
LATSPDVLNIRGKQLVSAANEQALRQRAPMISDPFVSLAGNYLINISQPIVSEEGHYLGY
VSGTIYLKEENVLGSLLGEHYYQDGSSLYVVDRSGRILYHPDRRRIGERVAGNMAIQSVM
RGESGAQQILNSQGVEMLAGYAHVPANGWGIISQRPLASTLAPLSGLMRDVLLHTTPLAL
ISLIVIWLCAREISRPLWLLARYVRGSDTGGALGRVASVRPWYFEVASLKQAVLSSLFAS
QAKIERLSRDSSTDPLTGVLNRRGLDERYGLLRAAQLPGALLALDLDRFKRINDTFGHDT
GDLVLKAFADILQMTSREADVVARVGGEEFVVLLPGADLSVALSAAERIRERVAAHDMPA
SVGQVTVSIGVTVWPAGIHALRELQIQADKALYEAKDSGRNCVRAYTSA
>A0A744LK52|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASKLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Z4EGM1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVAWTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A378E5R0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAAQMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSADLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A378EEJ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MFYQWLYSSHSPWLSVNFIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFW
FSGAFFCSAYLFTLFQLLSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHK
YVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVA
GDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHL
PERMTISMGVYTTYDNSVTAEACVQRADEAMYEAKNNGRN
>A0A6L5BNP5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MGDATDIEPLKFNLSDFNEDMLHTIMELVSDGIWDWNANTGFVYRNPGWYEMLGYTPHSL
HNNVLTWETVMHPDDYSRVMALFDDYLNQRAPGYQAEYRCRRQDGTYIWIEDRGYILARN
ADGSVARMVGAHRSIEDKKRLLEQLERRNHSLEALVEERTRELSRVNQQLQIQLEENRKL
AETDALTSVANRYRLEKTLPQECDRAQRFRQPLSLIAMDIDDFKIINDHYGHALGDAALV
QVVECLKSCGRDGDLLSRWGGDEFILILPNTPLTDAREIAETIRHKLTNLLPVGDFQVTM
SFGVVQRFEEEQQTGLLARADQALYRSKVMGKNVISG
>A0A5U2Q8E6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A703T6B5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRWLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0L6Z8J4|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MKIKNQLLLTHGLLVILSIATVLINAIAYKGMESDANIINHAGKLRAISYNMGQLSNQIN
NQGNDSNYANLTTNLEHRIEELEDILAMLSEGREKSIVGINHNYTILQLEKIIKEWNEVF
KPSYLRILENKSINDACAQINNNIDLYVNSINEMVTSYSIYAEQKVIRALTINGGLVFLI
IIVTVYSFTSTNKRIRRPMKILMQELKELSLIDDEISKQLKNINTDEISEMTQYFNEMMF
DQLTKALNRRAGLSKLSRMLEYTNKRNLKMSLCFIDVNGLKEVNDQLGHKFGDELIVSVV
EGIKKEIRDDDMVIRMGGDEFLIVFTGIDQEVSEKVWNRINQRYQIINEEEERPYVISVS
HGIVEHDNYERSEVELLIKKADDRMYAEKKYIKEQLKVKIIKS
>A0A1J1JD76|diguanylate cyclase|EC 2.7.7.65|Planktothrix agardhii|TrEMBL
MVDLEQSEEELEQEVQDLRYQLEIAKETLRAIGNGEVDALVIAGLEGEQVYTLQGADSSY
RMLVEEMKEGAATITTDSTLLLYCNKRLASLVKTPLKNLIGTDFKEFISPSDLTLFESLS
QKANLGSGKAELTLIARDGTEVPVYLSINILNQKGVEVGCLIITDLSEQKRDEDIVAQER
LTRLLLEQAAESIIVCDHQGKIIRASQEAQRILGANLLLSDFDDLIKLELLPQQNCGHSL
RKKEKSSNSIFSIAPVINGHPYKGREVLFIRKDGEKINFLLSASPLSKPHSVFKGCVVIL
TNITERKWSEESLKKINEELEIKVSERTAELESLNSRLKQELVEQARTQQILQDQAQLLD
LANDGIIAIDLNDHINYWNQGAEKLYGYSKSEALGNNLVKLLKIPSPQSLEKIKQEVLQK
GNWEGELIQTNQQGNTVIIHSSWSLKKDSEGNPIAILKINRDITKAKQAEQAIIDSGLRL
AGILDMAQDAIISINEQQQITLFNQGAEKIFGYRANEILKRPFSLLISEFSFQKDCQYHP
ELLPENRLIQDIGEYQEVTGYRKDGTEFPAEVSISRLSLEAGKILTVFMRDISDRKRVEI
AIQKAQEDLEIKVQERTMQLATSNDELVREIAERKLLENQLHEVNEELEQRVEQRTNELA
KAINDLKQEAIERQKTTLALQESEARFRAAIDGSLDAFFLLQSYRDAEGKLTNFVLVDMN
SKAEELLSQNKDNLLGKELNDVFYQESNLGYFDHYLRAFRTRKGFEEELEVSNPNIKAKW
LQIQVVPLDDGIALTCRDITERKKNEEAAQQANQNLTRWVNDLEQRNRETMLLGQMSEFL
QACNSTEEAYQVMNDLLKPFFPKISGGLFVARNSKNLVEMVAIWGDLQGISDAVFSPQDC
WALRRGRSHFVPATTSNLLCKHIHQKNYRQYQLNSNNSSEIIPKPPEKNKLPATYPVMVE
HLCVPMIAQGDALGLLCLASEESGQISEDQQRLATAVAEHIALALANLKLREALEYQSIR
DGLTGLYNRRYLEESLEREINRAQRQKFGLGIIMIDIDHFKNYNDTFGHNGGDIVLQQLG
NILQKNVRGSDIACRYGGEEFTLILPEISLEFVKERAEQIRVEVQELKPKHRDQDLGQIT
LSLGISMFPNQGLTGESIMRAADTALYQAKEEGRNRVCVFGSNFDHYT
>A0A518IWN4|diguanylate cyclase|EC 2.7.7.65|Rosistilla oblonga|TrEMBL
MLLHRMLQHAPTNGFEVCVCKTAEAAIDRLGDHQYDGLIINLDHEDQDPFEVLLRIRNLD
PRLAILGITDRSDESFGLRMVECGAQDVIAKEMLNGQLLYRAMRYGIARQRQISCLKTAA
HTDALTGLGNRRALDQALDQAVADFAVDRQPFGFLILDVDNFKQFNDQHGHRAGDYVLSQ
LGSLLRTAVTGNDLCSRYGGEEFAILIPATSTAKAVAKMKDLLQRIAEHFVEFEGTQYRV
TSSAGLTISRPNDTVGSIIERADIALYRAKSDGRNRGDLNLPSSAAVPLSCETIAGGNQK
>A0A663B7Q0|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MSDFILARVSQTLATEQSLETLVRQLLEMLEAVTRMESTYLTRIDINAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVARRWHSCITAQELGITTFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVALIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQPPAAQQAYVTTLRQALCGVYFLGEQRINYEGASFGV
VICDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A811GWI0|diguanylate cyclase|EC 2.7.7.65|Achromobacter mucicolens|TrEMBL
MSSSSSDVPPAAATADAASGQACYLSASNAQAWEAVYQSVDANTRGQVAALVSDHAAQLV
DAFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVREQGDIDVLMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIAQRLRAGGLEGQAASVATQYVCNLFDLAIEQMSRAFMRD
INRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAASEFG
LWLQHKGAVLFESAPALRQIVEAVARLDDTVLPGMMQSASQAPESLPNQVRELQELVARI
KHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISLAQRQRSSFSVLLLDIDHFKA
INDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAALAAAEKLNA
EIRRHRFVIAEAGAMHVTASIGVATFDGHPDYAYLIDRADKALYKAKQAGRDRSVEA
>A0A380Q4V5|diguanylate cyclase|EC 2.7.7.65|Yersinia pseudotuberculosis|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMLSSSPKTPAVTFPVVMIAVISLSAAAY
LIFISKNDAGKNNYVDKSNYVDKSNHVDKSNHVDKNNYANKLNLFSILIGLLWAWQIILK
YEYLETNEDNYLLLSLFTIFFISTIALSDNFLAFCLHTAPSAITVILLDDFHNIFRIIFT
IMLPLIGFSLHHLMLRRTDNFTRKLVDHLSNEREKFSDLSMIDPLTSLYNRRGLESKLET
LLSQSPGNHYVLLLDIDHFKAYNDNYGHTMGDQALVRVSAAIRDAVRSKDIVVRYGGEEF
LVLLTHVSEEYASQLAERVRQRVLGLDIPHVFNHKVSTTVTLSAGISPLQAYDLAASLKA
ADEALYRAKRNGRNNIEFAKDELSNVQSSP
>A0A2H5ZAV3|diguanylate cyclase|EC 2.7.7.65|bacterium HR29|TrEMBL
MRLRMLRSGRAAGRSARTELEVGILQAALAALFCVGVGSGWLRGDPSLAPWAVGWIAGYH
ALALLYTLRFRARGRTIPAAEAAKGPLDVASVTAGYIALSDPSSPFWAVYLYALVAYARR
MSGPAYVVLGVYVLANLAAAQLIVEWRAEGSVGADRVAIMVAIGVVVFALAKATGDEFRR
SAGELRRAAETDSLTGVGNRRWFMEALPRLAFDPADRFAILMVDLDDFKRLNDEYGHLVG
DQVLADVGRVLRRTVRPGDLVARYGGEEFVIALPGADDLAARHVAERLRNAILATVPTSA
SIGVAVRRPGEPAESVVRRADDLLLAAKRRGKNLVATEEELAKSA
>A0A380Q789|diguanylate cyclase|EC 2.7.7.65|Yersinia pseudotuberculosis|TrEMBL
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHILTWNNGAERNTGYCAEEVIGQSFELF
YTPEDLVNGLSVKGLKHANQFGHYESQGWRVRKNGKRFWGNVTLSALHNSENILQGFVHV
TRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGRILTWNKGGERHEGYTREEI
IGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAINPIHDDRG
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHN
IGYVSNEIIGQHFGCFFLPEDIAAGLPGKLLKTAASTSRVEHEGWLVRKDITRYWALTVI
TAIHDHSGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNS
EGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRHTLLPE
GHHLVSRRGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGL
INRRRLEERLTQTINQLAHDGQHMLCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCPSKSAVEILEQVVADIAAIQFHWHGQSYVLTASLGAIPL
TQQTESASQAMRLADIACYKAKHAGRNQLSLTS
>W0FUR3|diguanylate cyclase|EC 2.7.7.65|uncultured bacterium Contig927|TrEMBL
MKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKS
AMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSD
YSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIA
SILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDG
IFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRR
FLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSS
DYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNG
HPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4U2UPM4|diguanylate cyclase|EC 2.7.7.65|Martelella alba|TrEMBL
MRIDGPSYDNLILGEWRELIAFTGNAAHTLLLSLSNEDISPLVDDFYDYMLSDDDARLFL
SSKQVKERLHGTLLNWIKQVLGSSDANLEQLIAAQRKVGEMHARIGIPIDLVARGARRVK
LGLYQCLCREERDTALCYDAMRFASLVMDTAIEVMTTAYSRTHDSTTKDKENYRLFSIMD
NVNVERERQLAALLNWENHFIYTVATGLPVGEIQDLAESEFGLWFQHKGRHVFEQGDEAT
EIAALLGNTDGFIHGYSPAMLAVAEERYLLLRTVRNRVMKLTSLLSSLFDELAKFENGKD
PLTNLLNRRFIPTILRREIALSMRNKSPFVIAMLDIDYFKRINDQYGHDTGDQALKSIAA
MLYESVRSSDYVFRYGGEEFMLILVETTENQALQIIENIRAKIAHRPIHAAGGQKIELTV
SAGLCPFDGHPDFDRLIRKADSALYSAKQQGRDRIRTYRSEGK
>A0A087CAA7|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium mongoliense DSM 21395|TrEMBL
MSNSIEASIVVVDDEPSIRDLLVASLHFSGFEVETAASGSAAIEVIERTQPDLIVLDVML
PDIDGFTVTRRIRQAGVTAPVLFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTHEQIEDDPIIRVGDLEINEDSHDVSRAGQPIELSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVADEHGDTHKVTPLIETKRGIGYMIRG
PKAGQAS
>H1W802|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MFRILQGFSKYPQQALTSLKLWFLERKHIWITSSGVAAAVLIVRLVGLLQTSELAVFDVL
VRARLPESPEDRIVIIGIDEQDLREYGFPVSDAILADLLYIINHAEPRAIGLDLYRGIPM
EPGHDEFTQALTNIPNLIGIELLETLKVAAVPPPPALAEIGMIGFNNFVIDSDGRIRRNL
LYAGSDDGQTRRSFALQLALIELEYHGIFPTLTDNYEVQFNGVVFPKFQPNDGPYVRADN
AGYQVLANFRNPAVGFKTVSLRDVLNGDVPPSLFQNRIVMIGSTAFSVKDFHLTPYSSSL
FEEPRFIYGVELHANFLSQILTTILEERPLMSSWSEPVEWLWIIFWSWVGASLSWKLRSP
YRSILMIILLSGGIFTGAYLVLLMGWWIPVVPPLITLGASGIVVTTYLAHIQEEFKRSTD
FLNSIINTIPDPIYVKTKDHKKMVVNQAYSRLVGFPVEMILKKSDHDLFPKREADLFYEQ
DELAFQTNWEQENEEKLTDASGVNHWIATKRSLHKDAAGNLFLVGIIRDITERKKSEETL
RQLAEQLEKYNAELQQRADHDPLTGLPNRQLFEERLTQALIWADTNQKFVGLFFLDLNNF
KPINDQYGHHVGDLVLKLVAERLRGCLRASDTVSRLGGDEFTIILPGIPSHADAVRVAEK
ILDQVTQESELDGHVITIGLSIGISLYPLDSQDYETLVQKADAAMYRAKSRHQNSYELTP
PVPPNITEA
>A0A0N0XML7|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MQSILSRRGALLRLRRTFQKNPQLAVIVMLCVVLGASTGHSVYRDYQETVRQQRAIVRDL
SRVAAAHARNTLQEADNALQQTLGLVSAAGGIDQINSLDYWWRIKSYAFNVGDCQGVWIF
DRSGKPVLESSTFPAPANVNSSDRDFFKAALAGQRFYVSTAFKSRVSGKLVYGVSRPIHA
RDGHIEGVALVALRIDNLNDFYALMSFDSRFIFGIYSNDGRIVARTPDMDAVLGRSVKDE
ALYQDRDGQSGMYDLPSPLDHVQRITGWQRVPEFGVIGYAALSHDLALRPWRVRTLTTAL
EAAITLAVLVAAVLWGFRATVRESQAQRLLREAALNQVRIIDELETAQQDALTGLYGRKL
MMEQAERKRQQAAERNDCLVFMLLDLDGFKAVNDQYGHDTGDQVLIATAAALRACLRPDD
LAGRWGGDEFVVAVSVSPHTARAQVDAIARRIVQRVGEIGYGISGSLGIAIFDAHISIDL
ATRRADAAMYEAKHRGKNGFVIWDESIGLVAAA
>A0A2H6F8B7|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin06|TrEMBL
MKNLIEEITEWEHTFDAIPDIILVIDNQYKITKANKTAAEKLRYERSDLIGNLCYKIFHK
TDEPPSYCPRHKSAATKKEHAEEAYEENLKGHFLFSVTPLHDSEGRITGTVEVARDISSL
KLTTAELQEREKLFRSVTEFATDAIISIESRGRIVYWNRTAGSMFGYSSDEAVGEPLTII
IPKQFRQAHKKGIKRFLSSPSQKLWPGTYDVMALRKNGSEFPVELSLSNWESNGEIFFTG
IIRDITERRLAEEKLHETSITDELTGLLNRRGFLTLSEKQFQVAKRNLRNFSILYADLND
MKRINDECGHKAGDRALVDVANILRRTFRSSDIIARIGGDEFTVLITEPRSADIENIAVK
HLQENLEIHNEQMERDYKVSISMGMAHFDPKHPRSIDELLSRADKLMYINKADQKTGRK
>A0A173XM10|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKTVIKYELTLNKAMRSALSYGTPDEQIDEFIRYLGRHIGADRIYIFEDCPKKNITKNTY
EWCADAVKPEIDNLQNVPMELIGWWYDLFEQKKNVIIDDMEDIKETHPDSYELLSGQNIH
RLVVAPFRYKDEISGFFGVDNPPDTDSMGLALFLDMMSTLIISMIKIRDTHNTKTRKARF
MGYAAFAQIYIFIHYINVQTHLYEVIKNTDNGFRDTTDGSFEIHIKKLLKNCCANEYLSK
ELAFVDIDTIEERLDGRSSIVSEFYGTAFGWCRGRFIPVDYDNDGRLLHVIYCIESIEEQ
KERENSLLSMAQTDLMTGIYNRGHGESLIEQLLHNKVKGMMCIIDCDKFKSINDTYGHSV
GDDVIIAIAHTLQNICRKNDIIMRLGGDEFAMYFPGVTEKKNANEIFERIFKRTEKLNIK
ALGDRRITLSLGACFYDGIADISYDSLYCKADEAMYKSKKQGGFCATIYEP
>A0A261TFP2|diguanylate cyclase|EC 2.7.7.65|Bordetella genomosp. 5|TrEMBL
MPKLSTELLAQRWKETCAPYGATEIALAQTLIEANTVVLADYFYNRMLIDPNAAFFLSDQ
LVRNKLHASMQDWLRAVFAAAPGGQFEQAVAFQRRVGEVHARIEIPVHLVMRGARALIRR
MHELLAAHRDIDLDTLIQTSKYINDVTLIAIEMMCHAYAVSHDRNARAEEGYRLLALSQN
VGAEKERQRAALLDWENQLMFGLSVGQQWRELPRLGKSEFGLWFTHKAAHAFDGSPEARD
VRGHIEAIDQRLDRIRDDSGEAAERIELLHAVRDTTKAIGFLVDDLFEQASNLESGRDTL
THLLNRKYLHVVMSKEVAYARKTGAPLSVLVADVDHFKKINDEHGHDAGDLVLQQTASLI
SSYSRGGDYTFRLGGEEFLVVLVDAGASQALNVAESLRRRVEDKAMVLPDGAHVRISLSV
GVAAHDGHPDYQRLLKRADRALYWAKDEGRNRCVLADDRHDPNLHGDEGAWQGPPIEAR
>A0A554XJY6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MRHVIEHLEHIQRLTRGRDRDSVDATFVEVLRALLDARRVALVQVVPTDDGERLWTRVSM
ERGWTEPQSASVLAALEQGPLLAADAAIAQALAQRRTLALTDTGGVRVVVPVVTDSADRL
AIVVECDACASGADWAVRLVEGLARIYENFINLLDSSERDTLTGLLNRESFDDTFYRATQ
PGPAADDAADPRRHRGGDAYWLAVVDVDHFKSVNDRFGHLIGDEVVVADGAVAA
>A0A6V8LRQ3|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MAEISRLRDELVRRAGETPGECPQGLVIARMCAGLTLDQWEEIAREGHFLQWLALPACGD
ATPHLERIQRTIEELAHQTRQDPLTGLANRRAFERNLKMELDRAYRGGTPVSLAILDLDD
FKAVNDRFGHPCGDRVLLSLAGALLGHKRIYDMAARIGGEEFALVLPGSGLAQAETTLER
ILQEIRQRKVACDGVDPAVGVTCSAGVVCTKGRAPVSVEQFVDLADKALYEAKRQGKDRL
VKAPIPDLFDTSRATLVHAQEKKFLFTGPDT
>A0A653PRG9|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MPAFVQSQDCSANDRLALAASVFAHTRNGVMITALDGSILAVNPAFTVITGYSEDEVLGK
NPRILKSGRQGADFYKDMWDSIRLHGFWNGEAWNRRKDGAHFAENITVTMVPDAHGHPSH
YIAVFSDVTKMSERRRWLEQKSYFDTLTGLPNRVFLMERLTKAIEESKASGVPLAVAFID
LDGFKEVNDKFGHAAGDNLLVQTAGRLAQAIRASDTLARFGGDEFIAVLPDLRNDSILPV
LMQRFLDASSLPLELEGIHVRISASIGVAILQADAYSPEELLKAADSAMYVAKREGRNCY
RVYRSGLFSL
>A0A5E4XAH6|diguanylate cyclase|EC 2.7.7.65|Pandoraea communis|TrEMBL
MPDAMPAVPSQPTASPYAASGASDDALMFDLAPVSLWLEDFSGVKQLFDEWRAQGVTNLR
AHFKTDPAHVSACSRRIRVIKVNRRTLTMFNASSLDTLVANLPRVFRDDMLKTHVEELCQ
LWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEGTFERVLISLEDVTELEHARQRVTM
GEEYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVHPEFVERCMNEIHVL
DVNRHTLAMFVAPDKATLLARLPDVFRDDMRHNFREQLIDLWDNKLFQQREVINYALDGN
EINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYVDEL
NRLERKGPYPVTVIVADLNGLKLVNDQLGHAAGDGLLRRAGEVLSKAIAAPQIAARIGGD
EFALLLPSTDTSGGAAMIEGIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEATIQRAD
LLMYEEKRSHYAGSVNERRATGGTGGSGA
>V2U5I9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus CIP 110367|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFVFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSPLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A653J6M2|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MVDARTSEAGIRAGLAAGVGYCVLATVTIEMTSSGHDHATVWPADALILALLLKSPRSMW
PTVLLCGWIGNLLANMIGRGASVGIVFYGAINMAQALFAAYLIERKFAGRRDFLSDTKAS
GEFLLYAGLLAPGMGAIAGSLVSLLAYGVPFEDSFLRWFASNAIGLLIGTPVMLALLDGS
YRRCFGAKTGLERAETMALMAAHALLTIAVFSQTRYPLLFLPLSSLLLVAFRLGRLGTFA
GVAIVAWAGAIATYFGVGPIALITDGPVFQSLYFQIYIAVILCTALPVAATVASRADALA
ELAEHRKALQQILANAPEGILSFDETGTCRWADGRLKEFTGVEPEAFVGSTLDEVASLTS
QALLQFADAAAHGTHDAITCDFSPDRMPERTLEASVGIVSQGDRRSGMVITLRDISIRKS
REVAISIMAETDDLTGVLNRKGFRHRITTAIEHGHGPLTLALIDVDRFKTINDTFGHAVG
DRVLEAVAERLQAGTRTTDFVGRLGGDEFAILFGCDVDTARIACERIAAALRGVPMVNEG
AIKARASISCGVAQLQPGMTRSHLFDAADNALYEVKRAGRDGVRVAA
>A0A8I1G4H9|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFEVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVQKTTLLNRDDERLSHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDHYWYGVVAMDFTLNTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTGNVVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A0N8NT26|diguanylate cyclase|EC 2.7.7.65|Oxobacter pfennigii|TrEMBL
MEKNKLFYSSGQVKRHMIFAGRLLLLLTVIAALIVSSVQNYLFFHTVVEFFCIVMGSSLF
FISMNAHRISENRSFDFLGMAYGFIIIFNVLHTLAYVGIGTFSDDTYNMSVQFRIVSAYF
ESISFLVFSTLPHKKDNIQKISYGFSVLSVLFIFIIRILRVFPDCYISGVGQTPFKITSE
IIVLFMFCLSLYRIIKNKNKFQYKVFTLLTRSVALMIITEILFTSYATPQSPVNAAGHIF
KLFAYIFIYRVMVETSLKSPYVLLKRMNSELKSAIAQQKTAENELGIQRAYFQQLFESSP
EGIVILDSKDKIMKINKGFEGIFQFSSEEIVGKYLNDVIVPSYLHSEATNYSSEVLDGNV
VQHEAVRIRKDGSFVNVHILGYPVVIEDNLEGIFGIYRDITEQKKAEEKIFYLSFHDKLT
GLFNRAFFEEELKRLDTDRQLPISLIMGDVNNLKMANDSFSHLEGDRLLVSIANILKECC
RNEDIIARWGGDEFVLLLPQTGGDQAQRICQRIVAACRECREGHIQPSIALGMATKTNSE
QNIEKILGEAEQMMYKNKLTDHSRNYRISIASPESPITDAMDNAVT
>A0A518G2Z9|diguanylate cyclase|EC 2.7.7.65|Aureliella helgolandensis|TrEMBL
MNITSLHVLLIEDDAEDSLLIERLLHRYPLVTITTQRVSSLQEAIQTIQQGDFDAALLDL
GLPDSQGMDSLRQLHACDARLPIVVLSGVDDHAIALEAVASGAQDFISKHALSGGMLPRA
LFFAQKRQAKLLGLEAAADVDPLTGLKNRRNLQKAFLDLHTQDSSHVPLSAALLDVDHFK
AVNDRYGHLAGDEVLRQLSQSMRNTAESPHQVFRYGGEEFVFLLQDPLAAAEQRIGELLQ
TIEDRSIHVREQILHVTVSAGITQVRDGDSFDAALLRADQALYRAKADGRNRLVSN
>A0A653IZM6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MHVCCSACAARSRSPLRQTDHPWRYRLRDCRFASAWQYKSAEPLRKAWARVSGQVFLTRL
QSLDLPHKSVDASAGVAGQPLWASPSSDRFLEVMVARVAKRIASEALSFLEKQRLDPTPP
NYTLAYCFVTAPGGAPAKEIAALIEDGLRLTQEATDDIISRHGLGGSGAAALDPENAAAA
LRHQMLKLADITSSQTLATAQFGQDLSAGMGRLGDGLADLRPIIASMIALAANAERDLAA
AAAETDRLRQDLDAARTDANIDALTQLPNRRAIDAILAKLEEANEPRVLAFCDIDRFKRI
NDNHGHAAGDRVLAAVAKVLSDACQGKGVVARWGGEEFVAVFQMTPIEEAAAIIEAARRS
LSQKRFRVRETEQPLGLVSFSAGIAGGHGPNSLIAAAADARLYRAKEAGRNIIISEGVDQ
R
>A0A7W8DYT2|diguanylate cyclase|EC 2.7.7.65|Rhodopseudomonas rhenobacensis|TrEMBL
MSARILVVDDIPANARLLEARLSAEYFDVLTASNGAQALEICSRAACDIVLLDVMMPDMD
GFEVCRRLKSNPATHFIPVVMVTALDSPSDRVRGLEAGADDFLTKPVADVVLIARVRSLT
RLKMMTDELRMRALTSMEIGVQAPEREAVAETGKGGRILLVDDRPSSYERLAPVLATEHA
VDVETNPSEALFHAADGNYDLLIVSLGLEEFDGLRLCSQARSLERTRHVPILAIADADNN
ARLLRGLEIGVNDYLMRPVDKNELLARARTQIRRRRYTDHLRDNVQNSIEMAITDGLTGL
HNRRYMESHLATLAEQAGMRGKPLALMMLDIDFFKAINDSYGHDAGDDVLREFAVRIRKS
IRGIDLACRYGGEEFVVVMPETDLRVASMVAERLRRAIAGELFAIEKGTKRIEVTISIGL
STLEKKGEPIADVLKRADVALYRAKHDGRNRVVAAAA
>A0A4U8QAR3|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MTEYLNHGMRKIMSRILEIRYTDLEEEKRLCQELLDWSEKCNDSYGKAFALTYLGDYYIA
VYDEENAGKCLQGAQSLILENHNWDDLHLRVYSLFGIYHDMRGDEENSIEYYLKAITVAE
RLNDAAGECVVLNNLAFAFQRHRCYEQALNYYLKAYRLQSVLEESPVFLSILGNLSEVFL
LMNQYADARKFIEEYDQTVSDSRQKKVLGYKNWCLYYAAVGENEKAFEYADLLLRSQEVI
NEDMLSAFETYHTLTQKMMDLNNAHYAKHFLKAMQVNCVEAGVDQMQALEETTIRYEFLF
EPVSKHTEVYHRFYEKNEGFRAKVNNVIVNAMKSKIHLDQLVQQKEIMQSEQETLEREVN
VDELTGVYSRRYLESLMRDRTSENARQNMGIIILDVDYFKEYNDYYGHLKGDLVLQDIAR
CLIENRQTGISSCRYGGDEFVCVCEGLAVEEIENFIKCVRDSLHSKALPHEKSPCSNEVT
LSIGFAAGEDKAQVEMHLLFQLADQALYQSKRSGRNTYSRKRVDLL
>K7VSA5|diguanylate cyclase|EC 2.7.7.65|Anabaena sp. 90|TrEMBL
MKKNITLPGDPLPFNSCFYIERTPIESDAYAELLKPGSLIRIKAPRHMGKSSLMLQLIHQ
AQIHEYSVVTIDFKLVDRQTFLSLNNFLRWFCMNVARQLSLASDLDDYWDEEIGSKVSAS
IYFESYLLEQIKSPLVLILNEVDYAFQYQQIAQDFLLLLRNWHEQAQQTPIWQKVRLVLF
HSTEVYIPLNINQSPFNVGLSLKLPEFTVEQVTELARRYELDWCDSQAVKNLMYWVGGQP
YLIHQALYDLYQQKISLPELLDNCTKGKYIYSGYLRNLLNILLQDAELSQAYNQVVNSTG
NNIFLSDNLVYKLDSLGLIKLSGYNYEPFCELYRLFFQKSLLIESNAIPWDKLKKENEKL
QLLVNIDKLTQVANRKCFDETLEIEWERMTYIQEPLSLILADLDNFKFHNDTYGHQSGDN
CLHKIAQAINSVIKNPDHLVARYGGEEFVLILPQVDAEAAIFIAEEIRETVKSLRIKIPE
LTKKNQLTNMISLTISLGIACIIPSGDFSLREFFEAADQAMYQAKKLGRDRSILSSKFKF
GYDE
>A0A4R0ER18|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrae|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLDTLNAWLLESFSVGINKRYIEAVQKQHMVGHVHARVGIPSWLIMRGVCEIERK
VFELMAQNPQHDMITTCSYIVQIMGFSTEIMCRSYEAKTAVNQEIKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGNAGFHHPILSKSEFGLWFIHKASYAFTGSDQVQLIID
RIYQVDQLNTAVIQCTQKDEILGLIQQVRDLNREIQLLVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIISREITFSRQNRTPLSLLAIDADFFKSINDKFGHAAGDLALKFMAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDVKRALNIAESIRKYVENGMITTSQGQQFRFTVSIGCVL
YNGHPDYQKFLDTADTALYAAKNSGRNRVYLAKNELQVAVANTAESVQL
>A0A2C9WT64|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrae|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLDTLNAWLLESFSVGINKRYLEAVQKQHMVGHVHARVGIPSWLIMRGVCEIERK
VFELMAQKPQHDMITTCSYIVQIMGFSTEIMCRSYEAKTAVNQEIKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGNAGFHHPILSKSEFGLWFIHKASYAFTGSDQVQLIID
RIYQVDQLNTAVIQCTQKDEILGLIQQVRDLNREIQLLVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIISREITFSRQNRTPLSLLAIDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDVKRALNIAESIRKYVENGMITSSQGQQFRFTVSIGCVL
YNGHPDYQKFLDTADTALYAAKNSGRNRVYLAKNELQVAVANTAESVQL
>A0A1S7RZF7|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tomkonis CFBP 6623|TrEMBL
MFTVLECVAVQHDRAVVLLAAVICLLGMLAFFHLLLRAEESPAGRKPYWVLTAAFAGGLS
VWATHFVAMLAYKGSVPIGFDFFFTALSAALPVLGFWLALRVPSQAGYSPAIVGTLVTVS
VAVMHFVGMAGMDVAATISYRWGAVLGGFAVAWVFFLLAFFLFRRSGSWKQRILLPAGSS
ILAICALHFTTVSATVLSPDPSISGPDPDSLARLMVIGAVSGVTFLIICVTATAALVDRY
LVDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGNDEASLIGKNPDDLFKAIDGQPAYL
PRHAPVEAIRERADRQQVFELAVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVL
TGLANRTMFQTQLRRQIENCDDEDEFALLALDLDRFKAVNDIFGHAEGDRVLKRVAAILH
ECARAGDVVARLGGDEFVILTARHTKADEARLLAETILGMFALKMNVANDPTAVGVSIGI
AVFPRDGLNDESIMHAADLALYRAKVGGRGILAFYDPLMDQEARERRQLETDLRLAVNRN
ELLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVSPDVFIPIAEESGIIISLGEWVLREA
CREASTWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKA
TLIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRA
VIGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAGAAGTTTRKKYSV
>A0A1C5R5N6|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MTNNRLNIGLFICHLDNEYANEICKGAEYAAKELDVNLIVFPGMFLNASFNDPENEIYDY
QYNSVFYYAKKENLDALIVSVGTIASFISQKSIEAFLDTFKDIPILTLESKVSGYPCLQT
DSTAGLRDAIEHLIIHHNRKHICFVAGRKTNEDALERLNVYRTTMKAHNIPVTEDMIVYG
DYSEYSREIVGKLLDDNPDADAIIFSNDQMAIGGYQELKSRNIRIGADISVIGFDNSHGS
VTMVPPLTTVNANTPALGYRAVGKIIQDIKAGEFCSSVLDSHFVKRLSCGCSLHENTEHM
PIDNSSTVTDILEYCDDSILGNIKNSFFGTIVLDQINSIWKDIIEIAVLPKAKPYPKNLI
VDKLMSLLSSPVTSFFSVTNIAFSFRCFSGVIIALINDPDKRSEYYRLNSHITSAIAQFL
STSLYQQEHDSKTGSWSSIYITRDTLTYGTDTAKTFSSMLAKLKDLGFAASYLYAYDEPV
AIQPDGSWKTPDTLYLQAFYNPKHTAVLSGETRRIASTDIFDNEYTGFEDRFTAVIVPIF
TNEQHHGLFVCNTDVDHFGHIYTTSLHLGASFKYLSLLKEQIQTKEQLVMSLNEIHEKNE
LLNHLSTSDELTGVNNRRGLMEKVEYLINKPANHGRKAMLLFADMDSLKIVNDKFGHNDG
DFALKNIANILMTSFRASDIVGRIGGDEFVCFAFIDDLDFPKTVQARIQELSNELNETCG
KPYYIEMSVGVSEFSCDPNIKIEDLLSQADSALYSNKRYKRMSVLK
>A0A6Y4XX61|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNNL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S4G3E8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MIGIVVLSVLLLIWHGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLL
SVLFIGSIAFAANIVAFTLYSLPPVSVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKR
YDNFAQQLMFKLLAERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDID
HFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAE
RIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHIL
VSDDMRAL
>A0A5U4L369|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPMAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A080J1K2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1-250-04_S3_C2|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A379V007|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HRKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A3S4IX74|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MCGTPADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMAL
YKAKNAGRNRTEVAA
>D8AEZ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain MS 21-1)|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A0U5ILD6|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MPETLLIVDDVPQNLAVLGELLRSAGYAVRAAKSGAMALEYAWREPIPDLALLDIMMPHM
DGHQVLAHLRADARTADMPVIFVTAMDSADAELHGLESGAADYITKPIKGPVVLARVRTQ
LELKRTRDWLRDQNAYLESEVARRFAELRRVQAESEQIQSRLNRQLELILGSTGEGICGL
DLEGIISFVNPAGAAMLGATPEALLGRRFHSLVHDPQGDGNPDREDDCPLHAAVTTGAAL
RTHLDLFRRKDGSRLPVEWTCMPLREDERLLGTVLTWQDVGERQAYLEQLERKSNFDELT
GLPNRNLLADRLARAIARSREDGSALALLTLDLDRFKQINDGLGRAAGDRVIQAIAERLS
RLLAPTDTLARGEGDEFVLVIAADELEAVTGYVRPIQDALGRPLAIGGRELVVCASLGIA
VFPRDGDCAEALMRNAAAAMLKAKREGGEGFRFYAPAMNASVLARLELEHGLRRAIQQNG
LVLYYQPQIEARSGRIIGAEALVRWPHPEQGMLTPGHFIPLAEDAGLVAPLGEWVLREAC
RQNRAWQDAGLAPLVVAVNVSARQLAVTDLVAMTAKVLRETGLDPVYLELELTESAALGD
IDAFVEASQRLRALSVSLALDDFGTGFSSLSYLRRFAIDRLKIDRSFVSDLPDDPGSAEI
VAAIIGLAHSLHMVALAEGVETAEQVEFLAAQRCDEMQGYYFSRPVPADELAALLPAQPF
GPPAASDGQ
>A0A145K418|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKLLFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A0U5E470|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MPATKASGVSTAGDQPGTDAGNPFEIPDEELRTRALLALRQGRFDLAEKLLVGKDVDQAA
LVESLRIYQAELEIQNEELQRSHHQTQIALNRFMAFFDSLPVAELVVDGQGLVKEANEEA
RRLFGLRDTVYHQYFFIRLIEERDRGPAIHALAHLRPEEPIDLHELKFRAKTNEVFIGDL
HMAALPTDEDEGRRVLCAVVDRTEAVLQREALRESRERYRIIAEFSSDWEYWIGPDARYR
YVSPACAHLTGYPSAAFVADAELFGRLIHPDDRHLWEHHLRAHLADESGSAAPIELRIRH
LDGHEYWIEHSCTPVFGESGNFLGRRGVNRDITELKRSREQLRFLAQHDALTGLPNRSLF
RQRLEEAIPRTIRRGSEMALLFLDLDRFKIVNDTLGHPVGDVLLKQVAARLAQGVRANDT
VARLGATSSSSSPRTSRSRTMRRSWPDACSISLRRPSMSRAASFFSA
>A0A822WEH8|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIVSTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A177HYV6|diguanylate cyclase|EC 2.7.7.65|Streptomyces jeddahensis|TrEMBL
METESEPYVRLATLRQLHRVMADMNTARSLADTLQTVADGVVNGLGYELAAVNLVRPDGD
LVVAAFAGNAAADALMTGRVGSRTSWERRLTMGEAWGDLRFIPYTEGWVLDDDDVPQWLT
DGPEPRFDDEWHPRDRLFAPMYATGGAGGELLGVLSVDRPRNGRRPGAWGREALQMYAFH
AAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRIL
RTNDALCRLLGRPASALRRYSFSDLVHPEDIGTLLRTSAEGGRAELRFARRDGTYVWVSL
RNSVVADTADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRTRLSARLCS
RPQHVAPGPVAALDAAYGGSATRVDMAYEAGYDTGYDADGHGFDFGQGADPVGGAFGAYD
HHVHTVAPSGMDDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLTSGVRDGDT
VARLGGDEFVVLADGLGLADAQDLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAQCGMST
DDVLKSADERMYDEKRSRPKQHRRAG
>A0A0U5IFJ2|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MARLPERDEEDLAPTGESSRGYAAGEDELHRLMHDLRTHQIELTQQNRELRDAQRALEVS
RDRYARLYDRAPVGYCTLDRDAIIREINLTGASMLGTERARLTGTPLWSHLDAGQARALH
SHIEAVQRSGERRTLGVRLTPSNTGHVVDLRLESEPARGDDDESVCLTVMIDVTAQRHLV
EQLKEREQALSHLAMHDPLTGLANRSLFSDRLDQAIARGQRTGEQLAVLFIDLDRFKLIN
DSFGHPFGDEVLKDIAARLKEQIRKDDTVARIGGDEFLMLIAPVDSPDAAAAVARKLIEL
LRRPCAGPRGEIALTVSIGISVCPDDGTVAEDLVRQADTAMYMAKQDGRNTFRFYAADMT
KQAFDRILLRTGLSHAVERNELALFYQPQLALDARRIPGIEALVRWMHPVLGCLAPERFL
ALAEETGLIRGIDTWVLRTALTQRKRWQSEGLDEGTRIKINLSRRELERPGFAEDLGSLL
RELDLDARLVSLELTETGVVSDSAAALNTIQRLQRLGVELSIDHFGAFSSSLADLKRLPI
GELKMDKSLIDGLPEDIDDAAIARAILALGKTLGLRVIAQGVETQDQADFLRKAGCTIAQ
GFLYTQPLGPDELMRFVETWT
>A0A8B5J7C1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDGNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A765T9T9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLTPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSNVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRYLQIFNTLKA
NMVDYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A6C9S9F4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
KQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A377BQM1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MATVLLILLPANIMTMVMYAFRTERKHISESETRFRNAMEYSAIGMALVGTEGQWLQANK
ALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLVSGEINTYSMEKRYYNRNGDVVW
ALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKP
NIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRIAV
KDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVV
CIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIE
QDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTH
LANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASVDAE
YAALQRRAGAARRDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGIT
LIDDNNHQAAEVMSQADIACYASKNGGRGRGRFTNRSKLPHIANGRDVA
>A0A8H1WGW1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSA
>A0A826R5U4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVILLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTALQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGRV
TIYEPQQTAKHSEQAMMSLDEQWRMIKENQLMMIAHGVASPRIPATRNLWLISLKLWSSE
GETIDELAFRRSFSDPALNHALDRRILHEFFQQTAKAVASKGLSIALPLSVAGLSSAPLV
DKLLEQLESSSLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSGMGVD
LIYGDVIADAQPLDLLINSSYFAIN
>A0A6N9S585|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDY
>A0A8H9VTM9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVAFTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3W5XZ35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEASNLWLISLKLWSCE
GGIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3Y4XZ79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNQVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDGNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHNERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFRQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNRSYFAIN
>A0A827FWS8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGHMWPGIALSCSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDSNIESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLKLQNDE
GNVIDEHVFRHDFSAPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A1V3CMB3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARISQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNQKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRG
>A0A657FMH3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Denver|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARLSAMLTLETMYVSRS
GFYLSTLPTTYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377D461|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLE
>A0A377DN96|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPEKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMV
LYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHN
MYQAKHQRGRKAGEITRIYRYDKAPGSTPGFHLTNTDWLPVPSGKVYS
>A0A7L7E8I6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSMTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376J9P5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKETLVEQLREANAALIAQSYTDSLT
GLPNRRAIFEKT
>A0A2X1IYK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRGEK
>A0A377CGF2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAKLLVVSVVMSFWLFSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVD
PETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A6D0IK18|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLWRRVMPIMHEISHLPGGHK
PLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGL
LNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESC
ARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETICVSVAKVSISGLPRFTVSIGVAHHEG
NESIDELFKRVDDALYR
>A0A1X7BLA0|diguanylate cyclase|EC 2.7.7.65|Roseovarius aestuarii|TrEMBL
MADGNALQNVSADIQSPLLDSELAMNILNSMEQGVLVWSADERCIMHNDRVFAVMEIGRD
ELYPGRRRRNFLKAAVARGELSQERVDQVEAHFASGAPFEFDRTLPSGRVVATNARPLPD
GGHVVTFTDVSQSRRAAADLAEAKQRAETAETQALNALQETQARQEEATLLAELDEWLQC
CKSLEELFEIVVTFISKLLPGSIGELYLYSNSRDVLDGVCDWGTSGLHDHIAPDSCWALR
RGRHYRYDMQRIAFSCHHVKEQAGGSDARDYLCIPIVAHGDTVGLLHVRFDQAADRKSMN
DAQHFAVQCGEHISLAIANVRLRDELHDQSTRDPLTGLYNRRYFLEALRTELAMAQRKDS
TFALLSFDADRFKAFNDNHGHDAGDMVLRAIAECMYDKFGEGQVPCRFGGEEFTVLLPGA
TLSEATQAGEALRAAVEDIQVRYGSGALPRVTISVGVAAFPDHGPLPQDLLSAADEALYR
SKDDGRNCVTVATSRHA
>A0A376TKX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTE
VAA
>A0A3T6CJR1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A447XFI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGISTLP
>A0A2X5HMS7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENTDISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPIVAHPALHS
>A0A1C3RE18|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MQQSRTTFFFLVLSIASIMLCMVASIYIGYQHLTQTQEAWTRDAAYREKVNAAFLMRESV
RERSFRLTIASTLDDYFDRDVELEAFRNEAGRFLKAREVLQKLNLTTEEARALETLENNI
RLARPIIEKAMIEVVEEDWSMETRKKLFNGVIAQIDVLNSLNAFVKVFEKASKREAVKAQ
KEINKAQNNMILLSAAAVVIALLISWFVLLSENRFKRRVDEDTEKLHDISNTDALTDIPN
RRAFDEFLQSSWDQALKSSTDLSLILIDIDYFKLYNDKYGHAKGDETLITVAQTLSKEVN
RTSDLVARYGGEEFACILPNTNREGAYAVAEHLKETIEYLKIEHGPSMVSDYITISIGLG
SITPCENHNLSTFFKTVDDKLYKAKRSGRNRIN
>A0A376TFC9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEV
PDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAGTGFTVIRWTDC
TIYSKRHWLNSCAKPMPR
>A0A376TI84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIIFFAALVAVISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYS
MYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKV
VKILKSQIPVDKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAH
SNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A376M831|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQDFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGWRITKEMKASMNCLNALMMLCIGRKMMDATACWRHKPRMRLEIND
CA
>A0A376VJX9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASEN
ETLRTAERIRQSGRENQTESRERRRYCPLTFHRCRHV
>A0A4Y9E3I8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLVRRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376TVT8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVKPLGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDV
VHDVRSNRNFFPTSFGRTYR
>A0A377BQC1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHR
AVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEY
QLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDG
VLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAW
HDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHA
AGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRI
SASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVCASDNA
>A0A377K719|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKRTAE
IPLRSAKSTRYYRNPHRSA
>A0A5E9YYT5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A376Y6H3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPTGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLP
FDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5I9BI04|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eko|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1Q9QY07|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MVKNTPPFTAPPEAAQTLLALMHAQGEVARLSEREQLFSSLLDSVNAVLWAFDWESRQVL
YVSPAYERIFGRSASLLLADYNQWRDAIYPDDLDYAERTLAEVLVKGAVEDREYRIIAAD
GQVRWLSDKCFINQQGEGQRVIVVGMAEDITDKKQLEGELQRLATTDVLTQSSNRRHFFE
CAGEAFDRARVEGTPLSFLLLDIDDFKQVNDTYGHPEGDQVLQRIADSGKAALRRGDLFG
RIGGEEFAAVFPGCPPEMAMQVAQRLQREIQRLSFSHEGQTYGITVSQGLTGLNGEDGVL
DDLFARADAAMYQAKRQGKNQIVLG
>A0A379L442|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MMHNRSGKGLSFVKRIYPPRVVGMGIGLFSVMAGVAPQSPPTWVWGLMLFNGLLWPHVAY
LWASRSATPYRAEQRNLLLDSLLGGFWAAAMHFNPLPTVTVLSMMTMNNVAAGGRQLVLK
GAVAQLAGILVGTLLLAPGLQLNATALQIYACLPMLTLYPLALGWVCYRLAIQLGDHKRR
LSALSLTDSLTGLLNHGAWKDLLLVKYQKCKQQKAHAVIALIDIDHFKTINDTFGHVVGD
CVLRQLSAELRRNLRECDQAGRYGGDEFCVILPGTSEAQACQIMERLREQVSGYRNAQLP
HLRISLSIGLSPFNASLESPEHWLQEADKALYTAKHAGRDRVNFAGGAATALKLAYPD
>A0A1R3THH5|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MFQPLDLPTVLLLHKLSFFVAALCFLYVRSQSRESVGLGFLAVGFFLVATASTLVSIGKV
FTDYEHTLALAGTFAGLVGYSLFWIGMCRISTQKSRRREWLILCFPVIVCVTLFVTGLYE
FTTARTTAMQSTAALLLLAAACTVFFDRVIEPLPVRRALAATIGFAALLSALVVLGVLFP
DVALVSSRNAFFVSIVCHFAIAVFVLALVKERAEEGLKRLADLDVLTGVLNRRSFSTRLP
QQMRQGDAIVMIDIDHFKRINDGFGHFAGDEVLARVAQELSARVRPNDSFARFGGEEFIL
FMPATGEGEASTLAESVRQLVSSIKHSIDDQKVAATLSMGLAVCTDKTCTPHALMKMADT
ALYASKATGRDRLTVYNAEDFERNPALSNPARHAG
>A0A379L5A5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MKPTRKRSLRPTLRSVLGRAHLNVALLAVGLAGISLTLLGVLALSAYANHNLQLIARSIS
YTVEAAVVFDDSAAASEALGLIASAEEVAEARVFNGEGEQLARWQRADSGMLALLEAQVA
SALLDEPVKLPIMHQQQQIGRIELVGQGRSLLLFMLGGIAGILCCTVLSALAAQYLSRRL
LGDITRPLRGLASVAHAARRERSFDRRVPETAIAELNELGNDFNALLDELEVWQSHLQSE
NQTLAHQASHDSLTGLPNRAFFEGRLSRSVRNAASQQDHMALLFLDSDHFKQINDTLGHA
VGDEVLISVAERLRAQLREHDLVARLGGDEFAVLLTPLQTRRDAEHIAEKIVASMKLPVQ
LDSGRSVATSVSVGIAYYPEDGADPASLLSAADAAMYQAKRKRRGHWQVAQTERSANPID
NRS
>A0A125P0X9|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MKDKTQKARVMVVEDEGIIAMDIRRTLTDFGYTVTSVSATAEEAVKRSQTDKADVVLMDV
VLGGPMDGIEAAEIIRSTSGTPVIFLTSYSDEYILERAKITEPFGYLLKPFRDRELYVTI
EMALYKDKMQRQLRQSHDWFSTTLMSIGDGVITTDAEGHVTFINKAAARLAGLKEEEVIG
FPIGQLITLKDESAQEAANDFEDVLIPIIGAKTPISLTNHLLITNTGKAIAVSMTTATIQ
DEKGNILGAAITFQDQTKRRELENQLRHMVLTDSMTELNNRRGFYILAEHQLKLAKRFNK
EVAIVFIDVDGLKRINDTLGHLVGDSAIMDTALILQDTFRQSDIIGRIGGDEFVVLITET
LGITEEEVKQRLQTTTAIYNERKGSPYKISLSIGYVLYSPKSDLTIDALMQAADQLMYEH
KLRKHTNESSDQERQHNE
>A0A485CF66|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MNSHQQSSDLCVALIDIDNFKSINDTYGHATGDMVLKTVSDIGLRLRGMENITLYRYGGE
EIAVLFQGINLKKRRPFSIDGVKPAPSAGSVKRNCMLRLAAASVPKAV
>A0A2T0AM97|diguanylate cyclase|EC 2.7.7.65|Moorella humiferrea|TrEMBL
MALERIQVVDWLRVACKASKLVIYLASMIWLAWFSRRPRPGCQGTMLAGMMTGLALALTG
LSVDLLGEFFAIPYIVKRVVGELILFNLGTFLIAWSAATMLTELARASCRYQHEAERDPL
TSLYNRRAFFSAAERAFAKARSSGRIPAVAVLDLDGMKAINDTFGHQCGDEALKQAARAI
QKSVREGNVVARYGGDEFVVLFPSKGPREETLRSRLDKHLKAVCFSGEEIPLSLSVRLAR
FPADGESVDALLAVADARMYADKEAKKNSKGGYRV
>A0A836ZV89|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bifidum|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSAAASGEEGLELFTKGGIDLVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
GAVEASGVVDDDIPLVCGDISMQVGQHQVTVRGESVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRSKIEEDPAHLQYLTTVRGLGYKIDSPQQ
>A0A377J7Z3|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MVMSPRKVNILLVILTLIVAGVLVLHNFQQARHAEYINESWNDKSLEAMQTAMDLAAVER
SFGYLGFIHHFKNYVLRRDEVYFREATKAYWVTNDALVRLILSDLPERDVRDLIQVQRTL
NEYFRKLNDAYTHYAELSAKKLDAIVRVDDLAARDALSRLRIDIIPNLNEHYQVASQSNA
RYEQWTLLSITIPFMIIFGFAIVISVVSRKVLMRAREIDVIFQASPDAFIYSDSKGNILR
SNQMASDIFGYSALELKKLKIEDLVEPTKQEYHENLRETFVKQGGRRMMGGRNTEIKGVT
KSGKRVPLSIAISSFSFEEHQGSIAIIRDITDFKRLESDSMHDALTGVYNRRHIEERFED
EVKRAKRYARALSLLVVDLDNFKNLNDTEGHRAGDKGLVVAAEHLRSQLRKHDHIGRWGG
DEFVVICPELDRADAIEIAERIRRRFEAQQFPWCHKMTMSIGVASLSPDTSVMTPRDLFE
EADQALYLAKERGRNRVEHFFDLQRPKRVK
>A0A5C1C1T8|diguanylate cyclase|EC 2.7.7.65|Enterobacter chengduensis|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWAEINPIYTVVNVIEAIIGAVLLRKLLPWYNPLQN
LSDWIRLAIGSALVPPLVGGILVSLLVPGSEPLRNFIVWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLVETLATMAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRVEAFLVFL
VTVMVVSLMIAHNPSALTTQHEGPMMNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EARFRNAMEYSAIGMALVSIEGQWLQANKALCTFLGYSQTELQSLTFQQLTWPEDLDTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFTWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSFRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSEFFRVSAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISVDVVCSTDQNLQRGLQKLRQAGCRVIFSQVGRDMNVFS
HLSANMADYLMLDAEVVSNVYGNLMDEMTVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNASYFAIN
>A0A1F2PHZ8|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKLDNDQYRIIVESSPNMIWRAGTDTLCNYFNTTWLKFTGRTVTQEMGNGWAEGIHPEDF
DMCLKVYLEAFAKQESFEMEYRLKRQDGVYRWINDRGVPYYIGDHEFAGYIGSCMDVTDK
VEGQKLRDLAQRDGLTRIYNRQYFEQLANVEFSKAKRFDADLCVAMIDIDHFKTINDTFG
HHAGDLVLKTVAKTINESIRAFDLFGRYGGDEFVLLMSNTNYVEASILIARLKHVLETIE
IKYNDTLIRISASFGLYQMHHEVILEKVIIEADKKLYEIKNSRSKQPPHSVEQRPAL
>A0A1F2PM34|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MGQIQKNDAFFEELFRYNTEIMLLIDPESLRIEDCNISACEFYGKPHDQMITSKITHFNC
LNEEQLKKEIIRAKNKEQKQFYFKHRRANGEISDVEVRTIPLTLQGRNYLLSIVTDISGL
QLDSDLLRQENTLLEKRVAERTYDLNELNNQLIVAKAELEREMVFINALFESVPGYLYVY
DETGKLIKWNKKHEEMTGYSAEELAHMTLDQWFEGEDLIRVMAAVEAVYKTGYGEVDANL
ITKGGGKLLIRSNGVLMNLDGKRYFTGVGIDITESKRLETALEQESKLLETTLISVGDGV
ISCDRNGQILFINRVAEELTGWTKNEALGKPIEDVFDIVNDTSHEKAGNIVADVINTKSI
RELDNQTLLIASDGSERPIEDSAAPIIDEGGEVLGVVVVFRDYTEKKQKLEQIQFLSYHD
QLTGLYNRRFYEEELRRMDTQRNLPLSLIMGDVNGLKLVNDSFGHVMGDELLKKAASVIS
KSCRADDVVARLGGDEFVVLLPKTDQAVAEEIIARIEKLASKEKVGTMELSISFGFETKY
DKDEDIQQVFKKAEDYMYRRKLTESLGMRNKTVGMVIETLFDKYQKEMLHSERVSKLSAE
LGSKIGLNTKDSHDLKTAGLMHDIGKIGIADGILDKSEKLNDEDWAEIRRHPEIGYRILS
SANEFAEIADHILESHERWDGCGYPKGLKGEEISLEARIIAIADAYDAMTKMRFHMDTLT
VEEAIAEINRCSGTQFDPEIARVFIDIIKNED
>A0A0J6C4P9|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MKLPIDTFVLRWKETCAPYPSDILTLAHARVDQQAHELADAFYESMLADEAAAYFLSDQL
VRQKLHASLQAWLRSVFGAAVHHDYEAAVAFQQRVGQVHARIDIPIHLVMQGTRMLIRRM
RATLADDPAVEQTLRWPLSSYLGEIMLFAIELMSLAYASSHDRNARAEEGYRLLSLSQNI
GTEKERQRAALLDWENQLLFGLSVGDSAQSLPRLRKSEFGLWFTHKAEHAFEGAKEAEAA
RLRIEAVDRLLDAADAPDRIGLLHAVRDATRAIAYLLDILFEKANHLESGRDTLTHLLNR
KFLHVVMSKEVAYARKTGSPLAVLMVDIDHFKNVNDEHGHDAGDFVLQQVATLISTYSRG
GDYAFRLGGEEFLVVLVDANADQARHVAENLRQRLAGRTLALPDGSQRRVTMSVGVAAHD
GHPDYQRLLKRADGALYAAKARGRNTCVLAD
>A0A1F2Q0M4|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MPHGQARTIPMLPLLPPLTNFDDASRSIVSYLDEYLPLALWSITRFDGSNQIFLTVSPNP
LHIEVGETRTWQNTMCSEVVLGNAPPASSNRALVPALSRDDRWEGIGAYVSIPILHNDGS
LFGTLCGADPITGDSVLEDNLALLTLLCRLLGTILDVDYQRAQSVRLAETAQLDAETDPL
TGLLNRRGWNRILEAEQTRYRQFADPGSIIIVDLDGMKTINDELGHAAGDEYVQRAGKIL
AACAHPGAVVSRLGGDEFGIALPDTQPRAVDYLVECLEKAFRNADVCCSIGRADFSMFQS
LSETWDTADAEMYRHKRSKH
>A0A1V5C002|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin065|TrEMBL
MRENIDALTGCYTRSHLSTLNSMPAGYSLIFIDLDKFKPVNDLLGHAAGDMVLAKIADVF
KKNLRSDDIVLRYGGDEFVIILPGVAPAAAEKTVDRLLAVWQKNHPDTGHLRVGFSAGVI
QGTGDINHDIAAADKIMYEAKQGSNINVPFEPKSQVAFVTPKTVQEAVEYITKNKKQLMV
VIDTNRALLALRLTKISGQNDWRRWPAAKSAFLGKVEIYSTPGGREEKFDANDIRTLIGI
VLKGISEGKKIIINAGPGMVEELSGAVRTARRNALRTVAY
>A0A517N9F2|diguanylate cyclase|EC 2.7.7.65|Rubripirellula lacrimiformis|TrEMBL
MTDITSTTALSSLTATDFAVPVQAVGASDSQGHVQEAGFERVGDLLAGLRDSAPQATASA
SEDQPFENRLAVVRLGMATSLFYSLRTKHAATAGHCLRVALSCSAWAERLGLDSDTRDRI
EVAALLHDLGKIGIPDRILRKPGKLSVDEQLSMELIPELGCEILRGCTSDQDLLDIVRYA
NTWFDSRRHEEGPRGDALPIGSRMLAIADAFDAMTTDTVYRRAMSRERAIQELMQGGASQ
FDPELVRDFSRMLEARPEMLQQIVVDRWLRQLHKGSGPHLWGAAPADNSMPSDAGRASSR
ESLFHQQLIGNLKDGIAFTDAEGTIIQWNATMQHLTSIAPEAIVGQSWSNESLRLRQQDQ
TRDDCESFVRDCLDSGTASTHSMLIEQPGRTPTPVQIQVSPVVGSTPGIHGTIVIVRDLS
DQATLEEELETLHVKTTLDPLTNIANRAHFDHMLAERTDATSAGGPSFSLIICDIDHFKR
VNDVHGHPAGDEALKNFAEILRSHSRDGDTVARYGGEEFLLLAPNCDNATATRRAEAIRI
ALESTPLDSLMGEAVTASFGVTEFQAGDSPETILARSDRALLKAKDNGRNRVIQLGAGNV
VQSPSSESVNSRGWLDWLTGHNQSAVSEIDIVTPVPVDLAIEKLKGFIADHKAEVIHVDE
DQVSLKLNVTYSRGGRRRADQQMAVNVQLTLSEGRKECENRRGVMTTNVHVRLQPIRNRD
RRGQEVAACFAQVINSMRSYLMGELKRSDLA
>A0A094IG56|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR2|TrEMBL
MDVQIFNAFYVNMYSALLLGVLLIILYIKRDIYDFSGRVFKYMIILNIILLVFEAFALIV
EGVDDSFVRLINYILNFTVFLLTPLIGFLWAIYLDNKIFETRGRTKQYIAYIFPFGVGVI
LSILNLFFPVLFSISAANVYSREPMIMVNFFTLFMLLMYVAYLALANRKMVDSKIFRGVV
LFLFFPAMGGILQMMFYGISTIFSMFALAIFSTYIALETIGTSRDNLTGLFTRTKASEYM
NELIHKRSVFGVIMIDLDDFKQLNDTLGHNEGDKLLKVFGEVLMRVFHKDAIVSRFGGDE
FIIVRNNFDSDDLDFYKRSIYREFRNKATSNVFSEDFKFSIGCSVYSEGCLKSGEELVVE
ADNSMYINKAENKNFKRRKTDN
>A0A1V5VXV0|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MSELKDYILADMSKEELERLVFDFQNLIEIGISLSSNLEFSSLVESILYICIGQMLVDKV
AMFLHVNLDNEDLNLYMERGFNINQEWKIPEKSAMLQYFYKKSDIIVGDIIEELMGEDEE
TAELFSILKPEIVIPLFSKNALNGLIFMSRKIMETPYTAKDILFLEKLSKFASIAVENSR
LYRMATIDRMTGLFIHHYFKERLAEELKRAERNKKDLTLLMLDIDHFKRVNDTYGHLNGD
TVLKIIASIIHQNIRVFDMASRYGGEEFAVILTDTDEELGLKIAERLRAKVEEADFDLNG
TKIKVTISIGVAQFNPEVDDSADSIIARADMALYQAKNTGRNRVCCNSKDCRSK
>A0A7W5L7W5|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK312|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGLKALAICASTQVDLILLDIMMPGMD
GFEVCERLKSDPRTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELHMRNETARNFGIGDLMRSGEGRSEEAGQVLLVDGRANSQERIIRTLKPIAQ
VIAMSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
DMIVRALDLGVNDYIVRPIEPNELVARCLTQIRRKRYNDRLRASVQQTIELAVTDALTGL
HNRRYLDNHLKVLFDRSLARGRPLSILITDIDRFKTVNDTHGHDAGDEVLKEFAARIRST
VRGADLACRYGGEEFVVVMPDTPADIAAAVAERLRAAVENMPVKLRETGVALNITASFGI
SCRLETIDTPEQLMKQADLALYEAKRAGRNRVVASAA
>A0A1S8S853|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MEKNSVRYTSVIKRIRRRYILALCIIIFALLLSQIIVQYNINNEMSYSRIINIAGRQRML
SQKISKDVYAIYLSENKETEDLYIDELVSALEIWRKSNTDLQRGNIEEGISKISNKKIED
MFLDIKKPHEAMINSAYDIIDMVKSSNYNKSEFLSKMHIIQDNEKLFLKGMDDIVFQYDL
DAKEKILMIKNIEVILLAITLMLILFEILFIFAPAEKSIIKAFKDINESRKNFHKLFEVA
PGAMFLVDYDTEDVILINKQGKDFKSKLFGKDKKLNIRNIIFSEVENNDDWIKKIKFNER
LENQEMIITTEAEKNIAMLISSIKLYFGKKSTILLAIADITNQKKEKEDLEKLASIDELT
GIFNRRYGLSILEDNYMKAKIESGDFSICFIDIDGLKLVNDKFGHDEGDWYIKTVANCIK
ENIGENNLVFRHGGDEFIIIFPKIGSGQVNQIIDKIQKRLKIIEDLEGKTYKLEISFGLT
SYKLNEVDNLEGLLRKADYKMYENKKLKKVSR
>A0A1S8SDQ8|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKNISIKLKEVNFIALTGIIIISIILLTNFVKVLKYSYFELIDADKYINLSNNVEYFIP
KDNQYAEINQIADNSAIKFEKNNSKNIYFPEYVQKVWLKLKLQDKQASTDNIMYIDCEFI
ENIQFYIPTTDGKYVKEKPNEYFIFPYINLPENIDFNRDIYINSTWDSNVFNLLLAKDSN
FYIIQNLLACFYIGNLGVLLGMLIMNMILFFSSKDKKYLFHSLFTGSLLSLLYCLSGMQK
LILGFNSNNRLIALGAMAASTWVLFIYSYLDIKNNMPVLNKFFKLSILFLVLSLYISEII
PDGFTYDILYLHMIIVGLYILISIYSYFKFGMGSIYYLVGIFILFTGFIIYILGSYGLLE
WNIFAFSICYPAASIETLLFTIGIIKQIKHEKEVNNKLQLEVITDKLTNIYNRRYFEETV
VNKILQLEKEKSLVSMLVLDIDHFKKVNDNYGHSTGDMVLSETAMLIKQCLRKEDILVRW
GGEEFVAVLPFTDSKESTTIAETIRLSIENHRFKFVNKITVSIGIAEKDVVEDFHSWFRR
ADNALYNAKENGRNTVCVCYTNEIKNNS
>A0A8F5J219|diguanylate cyclase|EC 2.7.7.65|Crassaminicella sp. 143-21|TrEMBL
MLDIKNSRMKILEELYLGIQLIILLFGILTSHIFTTSDSYFHIKAFLLIYGLYLLVLLIY
FIRKTYFQNVYTFHPNLYLSFIDGIFLTIFLYLSNDIFHPVFHLFYIYITLQTIRFDHKS
SSLFSSFITICYTIVTIMRHPKDIISLEFIMNVFSFYLLSYILSSVMKEIYRLETQIYFM
LEEIKKKNAVLKEISSKDYLTNMYNHKSFYKYLKDVIEASEKKNTPFCLTIMDIDNFKKV
NDTYGHLVGDAILKEISSIIHDHIRKTDIGARYGGEEFAIIFPNASIEEAKKICERIRKA
IENHTFDVNNQKIKITISGGIGSAIIKPSSSNQHNFVAFVDNLLYEAKRLGKNQLQCSKE
IIYLDSY
>A0A3S4MGU9|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MTINIKDIDSSLLELNIAIRDHYNWANKCLRLSLLGGEPDKDVNDSDAHQHCRFSHWLNQ
RMQGANLDRELILLIDRQHAAMHVAARVLMLSIIAGKVSEELLNDYNEAQQKFISSIDKY
KEYLFSYRNLYDALTGLPLRHLLYQEFPLIRSRSERVERSLYLLIMDIDRFKTINDTWGH
NAGDDVLRSVASILKEATRNEERIYRFGGEEFIMLLEASSREQAERAGKRICQHLASHPV
SVDDQNIKVTVTGGLTLVSADDSLHSAIGRADKAMYYGKNTGRNRCILALSDQEMVTLE
>A0A5S9P3Y5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MGWWQTDQFDWFTIYLRERGLQVRWRLAVFVFTVFLGAVPLLLLASPAGPDTALRRGFAI
AAAGSAFAVSTLWLLRWPSRTQSLIYNVVCSGCIAAGCLVIPDPYGGLMGCTVFAAIGGF
LAYFHALAHVLANFVVAMACAGITATRMFLDTSDGLLVAASFLLVIGLNIGVPFGIYSVV
HTLRIDLRNSDRDALTGLLNRRSFYNAVHELVLAVQGSAGMRLNVTMVDLDDFKKLNDTK
GHAVGDQALITVGVVLQENCGPDAVLGRLGGEEFVIADTATATDHAVTAERIRAGIAAMP
FRITASLGTCSAAVPQDVWTTDPQFVDQLIQVADEAMYRSKRAGGDRSQHRHLDQAGAEC
P
>A0A7R6WAV6|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MKNKLLMHKKTEAVEKSIAIKLLNIIFGVYFCFTVVITIIQIHIELEDSKQVIITELGSV
ERSNYLSLEQALWVLDNKQVASIADGLIQLQFVTGLSIKDDKNNVIFSRGIVSNKHLFSH
QFKISHSHIVDNSKLKAIHLADVELFSDNSIVFERIKTRVISIIVSAIVKTVLLWMIIFG
VLKKYLFRPLSKFVDGIEKVELASLRNKAISIGIKENNELKVIEKSFNSMLLHLESQRMQ
LISHDEKLLEASCRYSEELERKVEDRTKELLISNEKLKSLSNTDPLTALNNRRYFFELGN
KLLAMARRQKKPLVVFMCDIDFFKKINDKYGHAVGDDILVSFAETVSPLLREGDVFARIG
GEEFALISFDSGLDDSVALAERIRQAVANIKHHLTDETIQFTISFGMASYQTENESLDDI
LHKADIKLYQAKESGRNKVCF
>A0A377Q4R1|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MEKSRIKNLPLAKELLLLNVLGIASTLLVCLALFSISYSYLAVQRLKTEAIVNANILAAN
IAPMLIFNDQKAAKTLVHSFITTPDLAYLSIVNTQNQIFADWGALHKDSQLFSFTHISNQ
PLTDMSFDHIAVLVPVSLDGELLGAVQLQIGFDAVYRETLQFFLLGLILTAIAIVTASII
LNRLQVRALAPIFELSTVAENVTLQRDYSLRSSYISNNELGRLSFHFNQMLAKIEKWEND
IKEELNQSKESERCLDILANYDNLTQLPNRHYFHQALATTVGRSILENQFSALMFIDLDN
FKYVNDQFGHEAGDLVLTIISQRLKNILRSTDMPCRLGGDEFAAILPQIADEEAAKILAE
RLVAGVKLPIIVHGEVMPVGISIGIACCPLHSDDPKTLLHYADLAMYQAKKAGKNTFCVY
SEKK
>A0A085AGA6|diguanylate cyclase|EC 2.7.7.65|Trabulsiella guamensis ATCC 49490|TrEMBL
MQSYVARVKEEWLGLIRETEPHIHEMARGLGEDNARNLSEIFYTNILTDPQAVDFLTNEQ
VETHLKKSLVMWLKRVLSCSENDVDELIAIQQHVGEIHARIGIPIQLVDMGARILKRNLI
PLIIERSGSDSDKIKLLSFSLSSIDLALEIMARTFTFGESSSMKEDENYRIFSLLENAEE
EKERQLGSLLSWEMDVMYNVMLEADLDSIQLISRADFGLWFNHKGRHYFSGIAEVGYIAK
LIQETDQILLKTREASRTFRQKNLRNDFMLQIKNNTTQIAALLRGLFDDVSKHEVGMDVL
TKLLNRRFLAAIFKREITHANRSGTNLSVLLIDVDKFKEINDGHGHATGDDILRKISQVF
YDNVRSSDYVFRYGGDEFLIVLTEATPAETMHIAERIRAKATKQAVTTPDGKQLTTTLSI
GAAMFQGHPDYERLVQAADEALYIAKRNGRNRAEMYNPNNKA
>U2FXW1|diguanylate cyclase|EC 2.7.7.65|Salinisphaera shabanensis E1L3A|TrEMBL
PIYRTNGALPITDHLEAKTERYYSEFRIRAKTGVWVWYANYGKILDREGAEPGHRFCGVS
FNLDIKKRQEQELQALNAKLREQNALLERMNAELHTLATSDSLTGIHNRRHLLKAGEDEF
LRARRLKHELALLLIDIVWFKRVNDTLGHVAGDQVICAVAACCARSTRAHIDTVGRIGGE
EFAIVLPEVGLDEALDLADRLRREVAQSRLPYRPITRLMSRSAPASRRYRRHANRFMT
>A0A4V1AC23|diguanylate cyclase|EC 2.7.7.65|Hydrogenophaga pseudoflava|TrEMBL
MVLLGLLALAALLPLTARADKVPGEGDITLSTRFWIDSSGSATVDQVAAESPGTWEAMDH
YRSFELGSSALWVRIEPGQLDSRRRWYLMLTAAAFTNDARLYTRGADGGWTEQRAGDHLP
VAQWSHPDQTPVFSVDPLLTEPLWLRLANAPAPTSPRLQLLTEENLQSKRYTTFLFIGGY
LGFGLLVLFLGWVHVRLYGDRAFVAYCFYVASMLGFQASFTGIGGLFFWPHWAVWNDLAP
SFFMLWLTGSGIWFVREACAVPRHSRGVDRFVVAWSLFGVVYSLVYAALLSPLAFKLLNL
YGLLSVVLSIALCLWTWRRGETYAGWLFLGFLPVHLGYPFPALRSAGVLPDSLATQYGVL
IGSAIEIPLLLYILHRRAKDFSENRARLRAMESTDPLTGLTIAPVLRLRLRDALKRARRS
GHRCGVMLVELSNHADIVAREGREAGDRALVVAASRLSGVVRDVDTVCRISDTRFAMLIE
GPQKPELLKLLGQHVVAKGLEKVPNLPVELPLRFRLVSSTPPDDKDSLEDALSDERLLAR
LNRALDRLSDDPRKVVLHLSQPPLQV
>Q8EGP7|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MKDSNATVTQLALLQQKLHSAKLALDEVNEDRNAKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHNLNTFDRVDEALPELVDVERLLKGQYHHVMVQLEESRAGLAQVIRQIQRVNSVP
EKLKKEINYFKQDLAKPFHTVWEYIPKVKQIIGFYDTILQQQFNGTEKLDVLPKHRQLAH
ELAQMISEIEFRKDQRDQVLVIKEMLASDIEIDNLLEAYQTILSLLLDNIAREKSASQEF
LYALNDALAAVREVVSESYNHNQRSFQLKTQLNREINSRVDNVGEAIIDTDDIVDLKARL
TEQLNSIRSALARKETLEQREQALLRKSMETMRKELNELSNEANTYKERLFEQQKLNLLD
SLTQLPNRAALEERMELEYRNYQRHKSPLWIAVADIDHFKIINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLILPDIDDSDIAQLLNRVREKVKNIPFKFKNQRITVTVS
IGAARVMGNELIHETFERADAALYKAKHESRDRVVIDV
>Q8EF28|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MTMIKNVHNQAFEAIHTILNSLDALVYVSDLHTYELLYLNDYGTTIWGEPTGKKCYQLLQ
AGQNSPCSFCTNHKLINHAGNSTTVHVWEFKNTYNNRWYQCRDQAIRWTDGRLVRIEIAT
DITDRKQMEEALIEAKSTAERLANTDELTKLYNRRAFFNLGLSIAQQSGQALAFIMFDID
RFKHVNDRWGHTTGDAALIHIAKLTQAILKPVDILGRLGGEEFGILLPDLHHEQACQLAE
SIRCRFEEQPLALNGQIIKCTASFGIASITIPVIHSEKEAQNLLETLFNSADQAMMQAKR
NGRNQVCSATELANFAQNNH
>Q8EGF8|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MDFGLATTLYPDEYNYQTDAYSPTSSPVDLVQVIQQLHASLDPRTVFACYGKVLGQHLPI
QGVRLQSEQHKLSWGKRYGISLKRQIICGGTPLTLQYQLLTPLTPSQSICLQEIEPLLLQ
PLLNAMQYQEMSMQAMFDALTGLGNRHYYSQSLKNAVARAQRKQGSVSLIVLDLDNFKKL
NDKYGHKCGDYILKEFGDIIRSSIRSTDQAFRIGGDEFVVIVQGNIHAAGLLCERIVSAT
NTHASFHQFGVSCSLGAAEASETMEAEQLYEQADKTLYQAKASGRNCYKLSPTQLS
>A0A8F9SD50|diguanylate cyclase|EC 2.7.7.65|Mycobacterium pallens|TrEMBL
MVMDAKTLFDPLRGRFRALNVQLDTLITQEIDHIRSVLRTANNSQWVALVILAASIIGCI
VVVQRMLTHPVSRLVRSVRAVADGDYDQPIGRGGPREFAEISAAVDDMRNRLRELARFDS
VTGLVNRAETMARLDAALNETGSRLGVLYCDIDHFKQINDTWGHAVGDAVLSTIAARMRE
CVHLDDTVGRIGGDEILILLPGVNSTEDAIAVGERIRALAAEPIHQFGLTINTTLSIGAT
SSAPGEASAAVTARADAAMYQAKQAGRNAVAGLDANVGVGTSTPNGHN
>A0A8F9WSS9|diguanylate cyclase|EC 2.7.7.65|Mycobacterium pallens|TrEMBL
MVLAVVPIERRRLADLINRRLRLSDVFARIGGDEFAVLLPHTPAAQAQKLAQELVDLVND
H
>Q321S3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATRGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>Q8EGB0|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MTNSPKLARQQPALSIVDDAALPTTKQLKDTELPLNFFEHSSLETIELFIQHLTEAMILV
NANGFIRSCNQRSAELLDCPQVSLKGQDWRNFLTEHHQARYDNLLSHDVQLGTNCGQPVQ
HPAQETTLICASGKAKDVELSISYIPGHEPMFVMVMHDLTHHKAENQKLRKLAATDSLTQ
LANRRYFDEMLQQHWEECTAKLRPISVVIIDVDYFKVFNDQFGHIQGDECLRKIAKVIAG
IVPTEIGLAARYGGEEFALILPNHNAKMALTIAQKIQQGINNIRFTDQGLRDYVSVSASQ
GIACEVNGQFRTSLAMVCAADTALYRAKADGRDRINTSL
>A0A449GRR6|diguanylate cyclase|EC 2.7.7.65|Gordonia paraffinivorans|TrEMBL
MARHPPISGVEQVKESAGRREIARGTAIYDETHHVLQQIRLRESHIRYSIAALVLVFGLI
AFCGLFSPASAQGSVIRSVIIGTAAASTIPAAVMVSRIHLGEIWWTKRSQVRGFNTWFVI
YADVGTAICVFATADPRVALCFCVLFAVVGSYSAHFVKPSVAYAHMIFSSTVTCVLGVGI
WLDGVAPIIAFTTTLAILVAVNSTVTLHQGYTSDMQRTLRHQLRMANTDPLTGLLNRRGF
ILATTTLLRDGTAGHFALFIVDVDRFKRINDDHGHATGDLVLQRLAGILEQAVDEPAVIA
RLGGDEFAIAVHLDELAAGVVAERICGSPVELDDGDQTTVSLGVAVGPIPGGQLIDEAAT
ARIQRDFALADAALFESKSARRGTYTITRAGEIAS
>A0A7G9KN52|diguanylate cyclase|EC 2.7.7.65|Xanthomonas hortorum pv. vitians|TrEMBL
MDLQAVSDEALADVSVYQLRGDSVGRVWVGHARGVEVYDGEHWAHLSQSQGLLWDDVSEA
AFAEDPDGSVWIGTARGVSHLRDPARLFDQRQPSVRIDSVSRGGVPVQRGQLLAWSDRPL
HIELSSMEVYDDPSRLTVRYRLLGLHNEWIQSDTLSIDQPPLPSGHFRLQVQLLDRYRRT
TSPIADLPFAVAPLWWRSPPAIALYLLIGSALLAGLWRWRHRHLVARERMLAELVAERTY
QLEREKRELESARAALALKASHDALTGLLNRSGVLEAMAEELQACARGAHPLAVVLIDLD
HFKLVNDEHGHLVGDAVLAKVGARLTACLRDSDRVGRYGGEELLLLLPGMSQHSQHRLRA
IHEKLSVAPYQVGAARPLPVTCSVGVAWFRIGDTAATLLARADEALYRAKRYGRNRIEPE
EPASSVA
>A0A8E7RDX3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanleyville|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEIAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0T9PAB1|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MSSIKNKSAGQIKNQTNAPKLPTLGRVLGRVHLIVALVSVATAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDTDAASEALAMIAANEEVAQAKIMDVNGRVIAQWTLPND
GPMHQMEQSVARWALPEPVVLPIVHSGNEIGTVVIVGHGGSLLRFLLQGLTGLLVCLILS
TAVALFLSRRMLLRIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSQDFNGLLEE
LEVWQEHLTRENDSLAHRAAHDSLTGLANRAFFEGRLSRTLNDCKTNQHAAVLFLDGDHF
KEINDNYGHAAGDVVLTSIADRLRALLRESDLVARLGGDEFAILLAPIHNTDDVLTIANN
IIKSMAQPIVLSDGQEITTSLSIGIAIYPDHAQTPDELLQRADEAMYQAKKGFRLHERGI
VYQSEFINSESLG
>A0A220W4U5|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. SMR4y|TrEMBL
MSENSGFHIQTIMILAIFALVFWLIHFFNRRQPFSGWVAVAYSAALAAYVIDSTRNESTH
IGFIYASTSLFWIFSLAIAKAIYARCNAAFPNVVVGLILSSAITAFAVLTFVAPDISIRS
VLVSVVAAILLALALPPLWKAGEKVIDGALFGVIATVATIFIVRILIVYSLHGLTLTEQS
YAQSEYAWILHFTSGICALALAVVLLYAAGLDMVWHFHGQSNRDPLTGLLNRRGLKGLFN
ASAAQKPDEELARALILFDIDHFKRVNDQYGHAAGDNVLKRVAKTASGLCQEQGQVARTG
GEEFAILTDWIPLESAQLLAQHICDSLRFVTHPELPADHKVTASFGLVVLADIDSLNDAM
DRADRALYQAKRNGRNQVALAQAA
>A0A087CI01|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium psychraerophilum|TrEMBL
MKILVADDDRTFIEMLRAALLMQGYEVSVASAGDSCLASVSEEKPDLILLDMGLPDIDGI
TVIRGVRRWSDVPIMVVSGRTETTRIISALDAGADEYVTKPITLDELLARVRALIRRVPH
EHGAPLITMGHVTIDLSTHSVFRQYRGRQIRVQLTPTEWKVLQMLVRNVGRLVTRQDLLT
EIWGSEHVNDSGNLRLYVSQLRKKIEQDPAKPQFLKTETGMGYRLELQDSANH
>A0A220W2H5|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. SMR4y|TrEMBL
MMWKPGNDNRNEERLQFEAEAARQFALERYDVLDTPEEARFDHITMAIKQALKVPFAGIS
FMDGERLWFKSKSGLKTTEFPRDISFCGFSIAQQAPTIVQDTLKDERFKNNPAVVGSPFL
RSYIGVPLITPDGHNIGTLCAADITARQFSDDKVDRMKQLAELVIHELELRQQSTRDRLT
GALSRSGFAVEVRKAMSLYERQGIKSTIVLFDVDLYKMVSSSLERASGNALLRSIIQTLI
QRLRQSDYIGRLGGTQFAVLLTCTIGEEARQAMETVQSEWEQANSEIFFDVAFCDISPAM
EGWEDWIEQASTKLRAVKEAGRKDFRHEPARRLKTAGRVG
>A0A345C8K8|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. W17|TrEMBL
MCVKHDIVSGKEAFTAQHRFHPGRVVNICFIVVLIFSTLLTWREAVVLEDAYAASQKNHL
ETVANSLDRQLEFSVEKLLFFRNGMDDALEAPLASTLLRNSVAHFKDLQEQTFWQLTFDA
RRTLPINGVSDAFVEQTTSLRRDEERLAKELSATFEMGYLLRINSPAAHAKRVVYVSRAG
FYVSTDPADWAADVVSRYYQLVTSPWYTGQSERENRTRSVRWFTHDADERTVTVSVPVDY
QHYWYGALALDFTLPGLNKLLQDAVDGNGEGEFQLYDKGFNLLATSESVADNVNHFDERE
RAQIAAALEKDTEGDIRLGSRYVNWHHLDHFNGLVLRIHTLREGANGDFGSITIALALLW
LLFTAMLVGSWFVIRRMVSNMYRLQHSLQWQAWHDPLTRINNRGALFERAKVLAKRCEQQ
KQPYSVMQMDLDHFKRINDRFGHQAGDKVLTHTAGLITRTIRETDVAGRPGGEEFCVVLP
DTGPEQAMAIAERIRERINRREILVKKSQTTRVSVSIGVSSAQENGHYDFEQLQSIADAR
LYQAKQRGRNQVVGQDEKK
>A0A178WW23|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MTQAPVPIGVRGAVTAWRGWPPRWAMWAVARRRWIGYAMACEAVAGALMVTGLATGFGGP
VQFSSFGVLVGLGIAQAEMSRRIERLRRWMSGQTHINVTSVWYLAGAFLLPPAWVALLAL
VLYLHLWLRVWRHVRTRPAHRFAASTAWAMLSCFAASAVLTIGGLDQARLDTAYGVLALV
LAAAVFELVNVVLVATGIYLYTTSRSPADLIGTWEDNAFELATLCLGGLAALAFVHQPVL
VVFVLPPLLLLHRXXXXXXXXXGWHELATREFTRARRRGTGSGFAVLMIDLDHFKRINDT
YGHLTGDEVLAAVAVAIEASVRQSDTVGRFGGEEFVVLLPATGDTDVLGIAERVRVAVGE
LTVAVGGPLRISGLSVSVGVACYPQAGNTLDEVLRSADAALYRAKDGGRNRVAV
>A0A140L9F8|diguanylate cyclase|EC 2.7.7.65|Thermotalea metallivorans|TrEMBL
MELVNGRYKILHYVDKDFYATSYIAMDLYNHNEKILIKIFEPEFSKSDLIQHYIDEYIYF
TSFEHETLLQNKSFDIIQTIDNKTPSTKQFFYTREYVPYNPIKYTDLSQQEAMEAFVKIC
SGIRYLHFRGICYKYLTLDNIFLYKENNQIQVKLKDLAYVKQIEFDRGKIAHYNQQFIAP
ECQMGLEVDFRSDIFSLGVLLFYLYYGASYKNNEFKYLYDSLKNNRNEKLDKMIKEMTSF
EMDERYRNIGQVISAVRELGEGEFMPIEDRGNYERLNFNIKLIHRENEVNKVLKTFNDFN
KAHMGPRAILVEGEAGIGKSRFIKEVLYRFRMDNVHAYFSEYLEPNAVQHKALKEILKQM
LKNAHYDLVKKYGPELVKILPSIGNIWDITPSPVLSAQKEKLRLYDRVFHFIHDAVSLKP
AVMILENIHLADESTLEFISFVLKNKKKFPVFFIMTCRTEEQDGISRFLKEWETTEKISQ
IHLSKFNLEETAALIQNILGMAWKPLKLATRIMKLTDGNPRYIEEVIKNLFIEGTLVVNQ
DNKWMIKGEGIGIDNVKLPSTIGEALLNQVKSLDENTLHVLKTISIFNAPVSPEIISNMM
DMDLSEAKDILCKLVEMKILGEKLEDWGYTYDYENRQLKNHIYRAIGKEEKAECHRKAAM
ILEISYDREGRENKDELIHHLTKCGNVSKAIDYCLESAQKMFSLNIYTQSLDFLEKIIEL
FGNCAEDHRKTTALLIMGEIYFNMGETDKSLYYYEEAVKIAEKFYQKREIVDGKNKISSI
YLIKNMIEPAKKMILEVIRIAKEIEYIDGYLEAGHLLSRTFFEQEDLENASRITDEFLKK
SITFGSYRYIGSFLNRKGNLLGFLGKYDEAMLAYIKSVEYLEKSGYHIETMKPINNMGVL
FMEAMQNTKMARKYYEKALKLAEKYNFIAGTSIYYLNIGETYLVEDEYQLAIEYFNKVIH
LDELTGDKISLSWAYLYLSEAYMKLNEYLKAYNYLKKAEGEMGNCSEPSRMYIYYHILKV
NFYFQVGSEKLATQWLSQEEALLSQTDKISGFEICSLKLLSQLDHMKNEGVQNILALIEK
FQREGFVKEKRRLLLDAALYFVEEGLLHEAAEMLQYDEKLSQTFDSKMLQHKRNYILGYF
TEDKIRYFENMLKEVSQREFLELEWRIYQILGDAFLKEKEYYKAINSYIFSLDILRRLTN
KIPNDLRLDYMNSSKVKKAIKPKILMLKKMILEENYEEDNSQEWNSSMEIEDLNAYFDFS
DLQRLFHNEKFLESALREYESLLPMKIASLRDLIQFLSSDHAENLEIVLKYCVKVSLATR
GFIILVDEGGNVRDTMKLYKHHKLPDIRYILERVSQKQDGILLKETFSTGLKSDYGYLPD
NAKAVICIPITAKQKMGNMTAPGKRKNWGKDETDRILGYLYLDTNKIFNNFDWSAYKTCD
ALCNLLYVLIENYHLKVTASIDKLTNVFMRKYIEKAFNNELIKAETNHSQLSIVMCDIDK
FKFVNDFYGHRQGDDVLRQVAEILRSNVREGDLIGRYGGEEFILILPRTNLTEAKTVCER
LRKTIEHASLLGDDHAVTMSFGIAAYPEHGNTQEELIEKADQALYHAKETGRNKSVIWDK
NIGSHRKRVDKLAGIISGNIAQDHRNVQVIVEIIELLKERKGKRKKIFEILGRLIEIIEA
KQGILIELAEDEIKHIYCRERFKEEWIENVKINEKLISHVLETKTGDYLIDWESIQDVDT
FAGTPDWQSLIILPIINQGKTKGVLQLNVPIKEKEFDFKTFNFVNSITGVIGAVFYENEE
VKN
>A0A1V5ZIK7|diguanylate cyclase|EC 2.7.7.65|Candidatus Latescibacteria bacterium ADurb.Bin168|TrEMBL
MPEATHTLTLFEYPVLVVGAAKLAKDLRAAFESPLTKAQLRRAVYLDHAPAESGEPLANK
IADCIDPRYQAVFLDATDPVLVDDRVLTITEIKKYCPATEVVVVIGKKTEGRLVELLQAG
AWYFLQTPITEAALTTIMVRVVAVREADALVRTDGLTGLFNRAFFEDALRDTVARLRLDI
GGQRTVTAPPVSLLLADLDGLKEAYGDRHQEGEMFLREMGGVVRKRYRPTDVVARIGGDE
FGALLVGMNYTLALMRAELLRKETLKITLPEGIGTRPTLSVGVVTYPSYFDDPQQLYWQA
RRALERAKAAGGNVVFGFDATGTPRPFVELGG
>A0A7M3G673|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVGQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A0Q0FNG0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MSPIFFILITLLLTSIIWSVIFLMAWFTLGKKSYALFWAGAFILSACQWGTILLRSHFDS
DTLYWMTGVSLSMGSVILGTWGHAIRARSPINLRYLLALAVITLASVYYYKAVDVHIGLS
MSLYIYYDILLLLINAVIIIKHKAKSLPAEIGAAITYTVCGVCLFIAATIALMQGSQVNQ
AYLDLYTLINFITVPTAHVGMAVFIIFIMASDLAQEMQKLAMTDVLTQCINRRGFYDIGQ
QKIESQLGCKQHVSLIYWDIDSFKNINDDYGHAAGDEVLVQATQRIKMCLQKDDIFARLG
GEEFVILIARDSELKAKQFADKLRETLASKPIEYEKQCINVTASFGVISIKSVNTPIDKA
IDLADKALYIAKHEGKNKVAYAMPLN
>H6RRK2|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MSQLFLVVVVGGALAAMVGLLQVIGDRGAERADAARLQVAEAVAAGVVRPHLVLNPPAQV
RLAAGQDAALREAVGQLRRDGHLHGLGVWQLDGTPIFLDVEAVSLGKWVSAADLARAGAG
QSWSEHAAAADGSTVLRVFVPIEMDPRVEAAVSSAVVAGVVIPHGALAQAEEHELLRQQV
TTVVLFLLMVSTVVWSRYRVLRREKHARQDPLTGLLNRRALQEDAPALLAHATPQAPVAL
CIIDLAQFKTVNDTLGHTAGDQLLEQVAAQIKGAVRGSDLVVRLGGDEFAVLLTDLRGVA
TARTRADQLLRKLQDTTFTVQGIELSVDASIGVALAPEHGGQAPELLQRADVAMYQAKRS
HRGVVVYDSSTDGHTIGQLAMVTELRRALDNDEFVLHYQPKISLADQRVVGVEALVRWQH
PARGLLPPGEFLPVMEASGLMQPLTQRVLRHAVHQAASWRRAGMPLKVAVNIGPRSLLEP
DFSARVLATLVGAELPASLLELEITETAVMTNPERAAFVLSQLRARGIHVSIDDFGAGYT
SLAFLRILPVAALKIDRSLVTHILDCPEDEAVTQAVIDLAHRLGLSVVAEGPETDAVLDR
LAALGCDEAQGYAISRPLNPAALEGWLTQRHVDHPATTDGANSRRRSLP
>A0A752IG92|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A737BJE8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica serovar 45:a:e,n,x|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAALVFSDNAAVAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARNSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLHGVHSEYEVQRICAALSLAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1S8KZH8|diguanylate cyclase|EC 2.7.7.65|Clostridium roseum|TrEMBL
MGRINDFLSSFLYIETFSIIVIAIYSWRRRKALGAFPLLFLCFSSAIYSFGYGMEITSTS
LESVNLCSKFEYMGLSFIPVLWVIQAYSLANKDKKISNIIKVLIFIIPTLTCIFRIANDK
LNFMYRNEKLISNGYFYILTYEKCFWYYIYYSFFFGCIVISTIMYYKAFLKASGLARRQL
KIIIFISISAILFEGFDQLQIVPIKMDYGAFIMFFVYVLFAAAVYPFDIMHIIPVSREII
FDWIYDGVIVMDTNFNLKDFNYAAKEIFKCLDKSLIGTKLELCTSEACEFMKMIKIWYSG
SEECSKKLLDGGFIKDTFEFRINSKGSVIYFKARLKALYYHGYRVGSTILISNVTKEKEE
VLELEKMARFDQLTGLLSRAYFTKYSNVEFDKLHRKNQTGVLVMIDIDYFKRINDTYGHQ
AGDHILKEMAFIAKNMLRNKDLIGRYGGEEFIAFLPQLSLKQAKLAIECIRLAFQNHDFF
YEDKLIKVTASFGMVECCKRTMANSYEQMVKKADIALYEAKKNGRNRIAVY
>A0A1A8XJT7|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MSSRIPASSGVDVQVLGQLLLMQSVVASLPDDAIIPFVLEGLSDIPGVGFVEFHAGSSSP
DGAPERFLLACGSSNLGELVFKVKYMGAFEPYIDHIRNFLFMLAIILDERRQRRILESRE
HELEYQIEIRNADLTRERDTAQRYLDIAGVMLMALDSEGRIMMINRKGAQLLGKSESALL
GMSWFDNFVPADKRAEIHQVFDTLMAGETQLLEHYENRIINASGQELTIAWNNRLIRDEA
GAITGTLSSAEDITGRRKAEERIQDLAYFDQLTGLPNRTLLQDRLQQTIAVSSRTGCHGA
LLFIDLDNFKTLNDTLGHDMGDQLLKQVAWRLMLCVREGDTVARLGGDEFVVVLAGLSAI
ETQAATAIETVAEKILASLNQPYTLGEIPHHCTASIGITLFLNDSSTVDSLMKQADLAMY
ESKTAGRNAARFYDPALESAVKERAALENDLRRALVDSQFLLHYQAQMLDDGRVTGAEVL
VRWQHPERGLVPPLEFIRLAEDTGLIVPLGRWVLETACAQLAVWSAVPQMTNLTVAVNVS
ARQFHADDFVDQVLAVLEQTGANPQRLKLELTESLFVSDVEGIVEKMFLLKARGVSFALD
DFGTGFSSLSYLRRLPLDQLKIDQSFVRDVLSDPNDAAIARTIVALSQSLGLGVIAEGVE
TEAQKDFLAASGCHAYQGYFFSRPLPLEDFEAFANQA
>A0A5C6AWM1|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MNDHVADHFHSLHSPDVAVPLPPVARDSVSRDGAANDAVNAETDSPSSGESASRLSDLLV
GLGEAATGEIVRLGQTSAVLGGQASSESAAHAENGNQVARQFENRLAMVRLGMATSLFYA
LRTKHAPTAAHSLRVALSCSAWCERLGMDADLRDQIEVAALLHDIGKIGIPDRILRKPGK
LTIEEQMSMDCCAELGCEILRGCTNDQVLLEIVRHSDTWYESRRQEDFVRGDALPVGARM
LSIAGAFDAMTTDQVYRGALSRERALQELFRGSGTQFDPELTRNFVDMLEKRPEMLHECV
VDRWLQQLQVSPDVSNRFFGRHLTSGGSGHHSTLPSSIDPAVLSELVGGAANLPFYETLG
DQLRDGVVFTDREGQILYWNDTMAFMTRVAASACVGKHWDSESLNFEDKNKSIEAGCPVK
ECLERQIVVTRTMRLRSGKVSSETDKNSSKNKPAENAGRDIIVQVAPVNEKSGGGAVVIV
RDVSDRAEMQNQIQSLHKKATSDPLTGAANRAEFDSRLMHCTTKAKQQGVTFSLIMCDID
HFKKVNDVHGHQAGDEALIQFAAVLQNHTRGSDLVARYGGEEFAFLAINSDNATATRRAE
EIRRAIETTPLKGLGGESVTVSLGVTEYQTGDAPETVIARADRALMTAKENGRNRVVQLG
SGLVEPDTKPETGGWFSWLSSSSQSKQQDFHLTTPVPTDLAVEKLRGFISDHRAEIINVT
GSELSLRINVQGGSGRRTADHHMTLDVKIHLNETKAVRGVKGNSFSQTQIIVTVTPVRNR
DRRSAGYAPCVRQVVNSLKSYLMAVLVSESAADLG
>A0A8D9L3A6|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MKRKTIGVLVGGITDDFTRLLCHGVIERAKTLDVNIVVIPGKFLDREYPETSDIYYEYQY
QTLFSYATKENLDGVIVASSCIGCFATKERISEFMKRYLQMPCVIVAADEPDQICVRYDN
GAGIREGLNYMIEELGYTRIGMIGGPDSNYDAKERRRTYIEVLEAHGIEFDPGLYVEGNL
TSESKEVFRDILDRNPDMQGVFCVNDSCASGFYEELKARDILPGRDISVMGYDDIEWATQ
IYPTLSTVRADAGKLGSEAVNLMVRLIDGKQVESKILPTEFIRRDSFCKKGGSRKRSKNV
IEGYLSMNHMLSEQWEERNKTQFKMKTFIQKVLSFDRGNDRSYGEILGTMDWLDIENAFI
FLYKEPIIHLIGEPFELPDQLYLKTKDLKEKVSSVITVNQKVSSSNLYDFESLGVEGAGI
YVLLPLYSNEILYGVLLCDLTEGVLVNGEFLGNQVSAAVKMINLLKTNEEIMKRLEESMA
ILQKNNIMLDNLSKQDPLTGIMNRRGFFDRSLQLLKECEEQKRTATVFYADMNSLKIIND
RYGHDEGDFSLKTIGDILIKSVGDNGIVGRIGGDEYCCLVLGLKDSDAADAFAEEVYSSF
EKFNEHCDKPYKVSVSLGNCQIVEYNKKGLQNAMTMADEKLYEVKKYRKKDVVKVKN
>A0A151AMV0|diguanylate cyclase|EC 2.7.7.65|Clostridium colicanis DSM 13634|TrEMBL
MDVINKRYLILKNIDINNVVSSYVARDVTNNNVVQLNLLNSDYTPEKFIRFLIENFIDYN
NIDSSNIIKTIDFGLVQNINERKIGYKQYYYTTEYIKGIENIKDVLKGCSSDCIIDLFVD
ICSGVHYLHLRSILYESINLNNIYILNNGNKYETKLCDLISVQIDKEFFSGDNRENLIFM
APEVINGAMPSKTSDIYSLGVLLYILLMLRIGIEIDFFYDIHKHMKNTDIKLDLNIINII
NKMICEEENRYRDVREIIKDLNKALGKNYSVNKKADIEKLNFNNKLVDREYELNKVLSVY
NQIKINRTQSNMILIHGERGIGKTKLLKEIERFIYLDGGRVYSIYNLKSNNLSSKGLYEI
IKKLLESCSQEILKNYECELVKILPYIGNDKQVVTLQSLMEKKEKIRLLKVSENFLREVC
ENDEIVFIVDDIHLLDKFSIELIEYLYNNNKNIMFILSYCDDDALFDKELSEFILKERDN
PNSISITLKELSEEGTIRFIKDILHLDKNPVSFSKKIYEHTYGNPLFIKETLKNFLLNKV
IYIDENTGIWCSDYDKNYENLPIPRSLEQACMNQISKLNKKSYLIIEFISFFNNGVSKDI
IKDFLNGWDLQCDFIIKDLCTKGIICEKIEDRGFVYDIYSKILKDIVYKKVNDDKKSKIH
SWIADIFERENEEDKCYEDEIIYHLEKSGQNHKAIRYCVDSSEKMLKLRNREGALLSLKK
ALSLLNSEEYILKIELLIKVSKLYEDNANYKLAIDYGKNAESICIKIGEKRLLVDVYNVL
GSAYLKFGKPDKAIKYIRASENLLMNMDYEKAYIKNRFILARIYLKNDENEKAISICNSA
IELCGENHIKYKAILFSILGEAYMELNRAKDAIKSYKESYKCSESINYRKGIVVALNNLG
IIYGDYYQKEDKMEECLVKAKEICETDKFVYYEIISLINLGRVYLYKYDYEKSLKYFLEG
LDKSREINFEKMFFYSLNQLSMAYLRTNNYEMAYRYYTLSQQEFKNCRKQVIDEANFYRL
QGEFLFNIGYMEKAKEYIKKAVNILSMRKFALKWRSEIQLQYINIIEEKIPENINKHINK
IEKLLSNFKKYNEFDIVYHTAIILYKKGKKDLATNICNKYLYNFNENSNPKIKLRYMHLK
SILSQDNNKIELMNSALKLSDKLNEQKIKYELCMEIGDWYLDRNQYIKGAHYYFEACKII
RGLLSGLPQNIKEQYIKINNLREPFYKLIYIRNRYVKPNINYNEINSVEKLLDFKYSMDL
LKEKTFIDEAKEIYSKSHSIVVKNEMDIINNLTSDSMANLEMILKYLARITLASKGKILL
EGQNEKYVTLVSFCEECDDGEDEEILKKVKSTKTPILLKYRYTLERDTAVICIPIIANNI
KNIPIERRKKNRKEYDLVKGYVYLSSDKILNNFSEDSLKQCTNLTNLIDYILDKYQLKIN
SCLDPLTGTLTRKCLEDKIEEFIEEAYENKNTFSLIIFDLDNFKSINDSYGHRIGDEVLK
KVSSVVLENIRNRDICGRYGGEEFIILLYDVDKYEAKRISDRLRRKIKKKVILEDNMPVT
ISMGVSVYPEHGYLKYELIEKADHALYVSKELGKDRCEIWKREFSSHIKHRNKLSGILSG
NLVQDSKNISSIIDLINIINQEIDLEKKIYDSLGEIMNILSAECASIIYMDEDKVKKSFK
RKINKEGWCKEQGCNNIIDEVVSKKQSICTMYWGEELGYGSINESSEWYSAMAVPLIRNG
IIQSIVYVSVPLKLKRFDYDDLNLFDTLCKIIRLMQ
>A0A0H2M1N7|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MPSSTDYESMFEFAPMSLWLEDYSGLRQLFESWRSAGVVDLVGHLNAEPQHVRDCMAQLK
VLSVNQSTLALFGAQSQADLLSRLDSVFRDDMTAPVIYELDQLWRGNLCFDNQTVNYALD
GRRLDVHVRVQVLPGYEASWDRVLVSLDDITERVRAERLRLESERYARELFERSPVSLWV
EDFSAVKTLLDDIRNRGISDFTTFIKVHPEFITRCMREIRVIDVNRETLRMFGAADKSEL
LDNLSGIFRDEMHDSFAEQLQDLWSGKMVQQREVVNYALTGDLLNIHMQFTVLEDRLATW
DLVLVSLIDITARKKAEAYLEYLGKHDVLTQLRNRAFFSEELNRLSRKGPWPVSVLVIDM
NGLKPVNDEEGHAAGDTLLRRVGEVLSKAVDEPGWPARIGGDEFAVVLPKTDERGAEAMR
DRIASMLELNNQFYAGQSGRVLSLAVGVATCEAGDQLDAALQRADRAMYEEKARHYRDSG
TERRRE
>A0A5J4DY65|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg02|TrEMBL
MAARTKYRPHRGNEQTGPGSPGRHATGARRGRRDPESCLGIPSTEIAPNVRSAVMRLMDE
LDQLKHDLSQAEDRVSELQDIADEDPLVPVLNRRGFIRELDRAIAYVNRYKTGACMVYID
LDGFKEINDIYGHAAGDAALKFTGAFLVANVRSSDIVGRLGGDEFAIVLHQADRSAAEAK
ARHLEQGILEEPFAYQDCKIDLCFSAGVAKISSTKSSAEIVERADKAMFARKKSRRRSRV
QQQD
>A0A679J8W1|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MDTAASPDLFEAESRALQAARTAYDTCATSATSATNEPAPCRQALGDLLGAYERLLRETR
RLVRRSDRAELEMNQLNLRLQDLAAELEYRATHDPLTGVLNRAAIIELVNRHFVRNDLAL
IVLDIDHFKRINDSFGHPTGDRVIQGVVTCLKDEVPAAAQIGRVGGEEFTVVLPGQGGDA
CRQVAHALRHAIEAYAFELPDGSSVTASFGVSWMPCGSSFDDAYGLADEALYVAKRGGRN
QVALASGPVHAQSA
>A0A4U6H3Z2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls714|TrEMBL
MMRNTTEIDAILIELNKSIDAHYKWLVNMFRCAVTSNATQPDIMGDNAHFVCQFGQWLNN
QSLRNEDDCSYVNKINNVHEKMHLSGKDLLSAILETRSYPWHFTKFEDALLAFTSAVMDY
KIYLLSIRSNIDILTGLPGRRMLDESFDQQLIDAGPLNLYILLLDIDRFKHVNDTYGHLV
GDVVLRALAANFLAWTRYDEVAYRYGGEEFIIIIRTKTDEQARQAGLRLCQLVGQQKIPY
ADGEIAITVTAGITRAQRDEKLDTALGRADRAMYQGKQSGRNRCMFMDEREQITLVSASD
GPSFHLSA
>A0A1V5L6X8|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.Bin444|TrEMBL
MTIGFQKGILSNAGVEVNESEDTFRSRAPSIDTAVSTLIWGSVVPLTGLLAISAGVLVFL
GGWWLTKASVQACALLACMCGGIVLVLGVCVQWYVIATRVRRPLQRLDMELRGTRTWAPE
KDLLLRALRESIEETRATSLETRDELSKERDRHALCRRRLSDCEATDRFFAAATEQLAAT
LSLADVAVRSVELVAEQWPDATVMLLQRTDTSADLESLAAVSPAEGPKAVLAMNGRMRPE
RPAYAKATLPLPLKEAFRSGTYLRLSSPVSQDPALPDCRSFLALGLEHRGAVRAVLYAAS
NHTDPPGLSALVRARPFLSMAYSRAMMAHELEDAALRDSLTGAFTQNHFLSLLRAEITRA
NRYAHPVCCALIDIDDLRRINTRYGAPFGDRVIAETARLVQEHVRTSDVVARVSGGRFAV
LFPESSADMAHIGAERIRARVEGHTYLVQRGEAERLTVSVGLAAHPPHGVTALSLMDVAH
SALTAAKEAGRNRVVVASE
>A0A5J4DUH5|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg02|TrEMBL
MVGEDQDFERTIAFGERALGYLKYNVTPAIPRYYELWYTYAAGHNMALINAVRELLAAKS
RLTPEETERLYDIFLSPLRKTEQVEEVGAQISAELKDIVDLVRELSSNSGKYGESLEDAV
AELDTVTSANQLKPIVTSLIGSTKEMVEHNRNLESRLEESREQITELNRSLEVIRTESMT
DQLTSIANRKRFDQVINHEMNEAVENKTPLCLLLADIDHFKNFNDTYGHQTGDQVLRLVA
HTLKTNVKGRDLAARYGGEEFAIVLPQTSLENALKLAEQIRRAVYTKELVKKTTGESLGR
ITISIGVAVYRPDEAVDAFIHRADTCLYAAKDAGRNTVKCETDADVEIKDFGPNAA
>A0A1E3WNK0|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MNRILVKLTCSFALLTTFPSNSQDLHSQWEETYANALKSDKSRALSLLQDRYNALEPGIE
KLYVSSKLHGFMILNGQPYHSKKHLFDAEFTAHEKNFIDALNAEEQLDFASANQRYRSLL
KYAEKKDSLDGKIIFEYHLCRVLNRQAQYQQANVYCSSLNTHIEDTPNALLPKHMAHRII
ANNQEFLGNYQAALDTYQKLLAHIPDYVDSSGIYNDAGLLLSTLGHFEKAKQYINIALTM
RGGHMSPLKLAQSHHSMGKVTLKQGDYRTAIEHFTMSKQIVKQYNHLIGLTFAQLGLGQS
YIGLGKFEQGTRYLLSALESATKQDNPQIRGEIYLTLASAHKQQDKLLAAREFALQAHDL
AESVSSERLKTKSLKLLAELSELQGNFSLALSYYRLYARSELSKRDKEHRSAFIALDTAR
RNFDNETRVSELTIDNTALRAQLANLEEKNHLALFGIILLALSFIGYIYYRRNETTRCEK
DNLTEALTRSAAIRQIKQQKIASNTTLKHVLVIIDLDDFKSFNDQYGYSCGDRALQHVTA
KIQSQLHNSDIVGRLGGEEFMVLLTEVDELDVTERIERLHHAIAEAGFKSDNGESLSIST
SFCYLATSKALSDFDELYAILDHTLYKSKTEGKNRIIDAYQ
>A0A1C7FHD6|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MLKKLTFVLLTIVLSILFMVTIESFLFQTSGQSEKAPTKPLLSPESQLLLIAPQHPLINF
LHQAEAKPSTAKQQLLEWQTSQTQDSAIIEQIYILWIEQEIAKQQNLGQKVRDYQQELAE
LAQEEGIYWLQAQLALEQAVASLKSDRYSDGLEKIELAIKLAETHQAEFLLLESYNTAGI
LYNASNQLKQSQRYFLQGVELGKKYPQSDFNGRFYNNLGLLYVHLELWDKALEHLTSAEQ
FYLNFEQTTDNVLIIIYLNKSYVYNQLQDPHLSRQSYLKAMSYFSNETPNYYSILALKAK
ARMELLLGNASAAEQDALQCLAYEGVDKRPKQAAICQYIQAKALHAQGLNSESIKVMTAS
IDKFQHIAHHRWLIRSNLVLASVYEADGQYEKALQLYKHYHGKERRQIIDEFHVLETAFE
VREVEKERDLLSVQNELIDLENQLNDNRMRILAFWFAVILLVTLWFISRSVMDRRQNRYL
QDLSYRDPLTGGGNRRLYYQELKTPYALNTKHSYRVVLVDLDWFKSINDGYGHEVGDEVL
AEVAKILRSQLKEHELFIRWGGEEFLLLIQDQPDFRMRAQSLVNSISKSPLALSQHQLPV
SISVGVSAACSIDDLRQDSEMFIVADKCLYRAKHQGRNQFVTVEDLSD
>A0A3N6H7Q4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI98-12|TrEMBL
MGDDLRLRAVVGLAQAMAAAQSPREVWRAAALGACGALGGGFAALSVWERDRGRLRVLVN
AGRLAPGEEEYPESETYPVHQFPEITEFLHERWAGGGEPDAWVETADGRAEGRPGYCHQR
VAALRRRGRGCCVVAPIVLHGRAWGELYVAREAGEAVFGPGDADFATVLAAVVAAGIVQC
ERLEEARRLAYTDALTGLANRRAVDARLDEAVEAHRGEGAVVSLVVCDMNGLKRVNDTQG
HAVGDRLLERFGSVLSLCGAMLPGTLAARLGGDEFCLVSVGPGADEVVAVAEELCERAYG
LATGEGVACGVASTGDPIGEVRSARRLFRLADAAQYRAKAVRARGPVVAGREAEPETGAD
AVLRLADAPPPEGGERRRIRGRRDGNGGTGGAG
>A0A0T9TJS1|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPETPAVTLPLVMITVISLSVAAY
FIFISKNYVDKLNLFSIIMGILWAWQIILKFEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPPALTVIFLDDFHNIFRIIFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLASSLKAADEALYRAKKDGRNKVAFAEDKLSKIESSP
>A0A0T9ULU6|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRVFGLGIGMFCVGSVLYTQNASLWLWFMLVLNGLAWP
HIAYLLASRSEQPFEQEIINMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFKPETSPLQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLMRIQERLADLVF
TQAPTLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A450C988|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLEKIKKFFGFPLDKKHKKNVEKELCNYLHHTGKIICIIIVISQIIMMISISAREGGPF
ATPRRQWYFYMYVTLFCVSSVFMFVFSYLWNKKKDCYTFYINLWIIYVTFFCLWGCVITL
FDQLGGNDLSVFSYIMLAAAAFSVLKFGESVIVFGGCFLFLNLFLPGIQTIPGNEFSNIV
NTFFITSLAIFVSTMLYRNRVFTYYDKLLISQQYEEISHINNLLNDKVMTDDLTKMNNRR
YLEDILQKKLISHANQEPITGMMIDIDYFKQFNDNYGHQKGDYCLQNIAKVILDFTSSEN
EHAIRYGGEEFFICIFNCDEADAKLKSECLRKIIESCNFERDDVPLKCVTVSIGVYTKKI
EKTITLNEFISNCDKALYTAKEQGRNCVAFY
>A0A7C8HZ34|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MQNSLSTKAIITPFEVSQDTVQENETGMWYWEPLADSLYFSESYLTCLGYTESELPTSIS
DWMNIIHDEDTEVIKYLLENYIQSAKCGNRYEHPLRIRRKNGKYSSVVVHGYILHRNAEQ
KATMVSGFHINSERVTAIDHEQQRMKFALQAAEDGIWDWNAETNHVYYSHKYIAMGGYTE
DEFPPTADSWASRVHPDDYENTVSMQLKIINSPEHGDSFECVYRFLHKKEFWIWILGKGV
VTSRTAEGKARRVTGVHIDINELQNAKEKLIKTLKKDTLTAVYSRYSFEQKLKTITPEDY
PVSLIYVDADGLKIVNDLLGHTFGDEYLRKISSMLATYTRDRDSIYRIGGDEFVILLPNT
GYNNANEALFRLKSKVEEQNSIDGSPFVSFGVSTAMFPDELCTLASNADSHMYKNKRITQ
EKRHELIRQHCLNIIDTTSREGTKAS
>A0A0F3QK98|diguanylate cyclase|EC 2.7.7.65|Rickettsia bellii str. RML Mogi|TrEMBL
MSANILIVDDIETNIKLLEAKLLNEYYTVFKASSGKEALNILKKEKVDIVLLDVMMPEMD
GFEVCKKIKSDPETTHIPVVMVTALSDVDDRVKGLEAGADEFLTKPINDNALFIRIKSLS
RMKSLIDELKIRNSTNALLGGINVEIHDNFADKKILLINDDVVQAKNIKQMLLKITSNVK
VISNSEETDTINEYKPDLIVISSTLENEDPLRVGAILRGKPEISGVILILQIYEDENGNE
NQMQLVMKGFELGINDYFVYPIDESELAARIKTQLRRKQYQDNLRNDLEQSVNLAAKDGL
TGLFNRRYFDVHIKQIVEKANKEGMKLYLLMCDIDNFKHVNDTYGHQAGDKVLITTSRIL
KNTFRVTDLIARFGGEEFTILLNDINIDQAIYTAERVRVKIESMNFQIDEQEEPLKKTVS
IGVTEYKKCESIEEFIERSDKAMYEAKTTGKNKVVKL
>A0A1E3GXR3|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MLDAHIGELVQLWEGQTSYSGRTVNYTLGGRRLDIELEATILPGHEDTWARVLFAIEDVT
ERESARRRHAESEMFARGLFEHSPVSLWVEDFSSIKTLLDEIRTRGIEDLRVFTDVHPEF
VQRCMREIRVIDVNRHTLRMFGAPDARTLLNRLGDVFRDNMQPHFREQLIDLWQGRLFQT
REVINYALDGTELNVHMQFSVLPGHEHDWRLVQVALTDITARKKAEAYLEYLGKHDVLTK
LYNRSFYADELNRLERNTPYPVTVIIADLNGLKACNDELGHAAGDALLRRTGEVLSEAVQ
KPAHACRIGGDEFAVLMPAADAREGEAMIEKIRKLVALNNQFYSGMTVSLSIGIATREKG
ERMEDVVRRADRSMYDAKRAHYSDRDIDRRRLA
>A0A655D2K2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MFLPVAAVLVTQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGM
WIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSS
LEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNE
FDHSRRHHREATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGD
EFAVIMCGTPADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKS
ADMALYKAKNAGRNRTEVAA
>A0A7C8LWA1|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MPHISNPYFFILLLLLYTGVVLFLVFYLLVHKKPAWIYKWACNRVAAFKDFGRFSPQFRT
KLYSSGAIIAIRFNLETGRVSAINQTGADLLGITKTNNEVHGSFKHGEFLSHESRKGLVK
ELNLHKRVENYPATCVVNNALVKILITAEKYENGDVEAMVIDITKHFNIYQKIEDQYLFL
QNILNALPVPVFVRDKSHQYPFTNQAFNNTFGDINSDSSNKYAFLIPPDFEESDVPTSED
SQYQASISSKFQAEFSTAMSTGVHHFEVRRRPLKKKNGQIFGVVGVATDITHRKRIEQDL
RDTTKRYKNLFWNAAEGITTVQHDGRLTEVNPAMASICGYDSPEQLLEEVHFVDKFWRYP
EQRAEYLKIVLENKTAVGFDFEFVRRDGTIGWMTISSSGKFDEHGNLEYIENIISDITLK
KQSELELTRCATIDSTTGICNRNALEGHLITLLNAKPATPFAVVFIDLNNFKPVNDNYGH
YTGDKVLEIIAQRLVANCRETDFAARLGGDEFIVILNEVNNKKTLSGITDTLLDIIKEPI
LLGGITHVVSASAGVSQYPADGDTTADLLKAADASMYDMKRSSKASKINNQLELLANS
>A0A5E5XAN0|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLQQYQQLQQTNKSIELRLTRLKDNGASREELALLHDGLQIADELQD
EQQAALAHVARGDAPAAIAVLYGKAYESELERMQTQIDHFRLMLEHRAAAAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFSQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIMVAERFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLSPAGEEPPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPQAHADQSLCVPLIAQGEAIGLLSFQNVTASDGPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEADAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTG
>A0A841GXN8|diguanylate cyclase|EC 2.7.7.65|Longimicrobium terrae|TrEMBL
MTDRATVFVADDNPSILQGLDRALKVTGYHVRTATSGRGVLKLLEEAADQVPDLLLLDVM
MPEMTGLEVLRTLRLNPRWVDIPVVLITATNDGALPVSALRDGAVDFLTKPFRLDELLAR
VERHVVRNQELKRAREQARMRLQAIDLIRELNRVVTAEEMFHLVTSRTSEILGVGRCSVL
VVHEGEQVVRVAASSEKELTEGLELDLSLYPEVREALQTRRPVVVRDVALSPLFDGVREE
WERRGMLTPLRSVIVVPFPITETVTGLFVERATVDEPLLGDEAAELAERVVEAIVQACGR
VQLFQKLVDQRKQLHDLAHTDELTGCDTRRSIVGYLTRQFDAARRTGAPLSLVLLDLDRF
KEINDTCGHLAGDAALRALGSWLESDGLGANERAGRYGGDEFVVVLPGVGPAAAQLFAER
ARAHFASIPFVFGEVTIRASLSAGVVSWPDADAATADELISLADTALYQAKEGGRNRICV
SATAAAA
>A0A8G0XR74|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MFAAYWAQLLGDHQARLQAADSDARTRAVQLSANAQAHVSSLVAGLEYVAKTLASTYESD
PKGAFVLAERTARKTFAHDSITQIGVADAEGRIVYSSLGKQPEGVSVADREYFRVQAQGG
QPRLFISRPLVGRVSGQWLVQLSYPIMRQGRFAGVLALSVAPSHFSQGFHDLFGNGSDVA
ILVRDDGSYLTISHPQFDVLGKSVPQDRGFITSPQAMHGEYRATNPMDGVDRYYAWRRLK
AYPLVVIVGLDRDRALAAARSANQQSLWRSGVGSAVILAALLGFALLFRRTQQDRALLQE
NRQRYLLALEGGALGVWDWSLASQRFSVDQHLAGVLGMAPDGIQHSIEGLQPLVHPDDWP
ALQSLREQIRRGQIDSFARELRMRHQSGQWRWLDVRGKVSQRNADGLAARVFGTFSDVTA
RRDAEAAQAELQARLAKLVAAVPGAVYQFRLCSDGRISFPFLSPGVINVYGVTAEQAMQG
DAQQLLQNLHPEDLQRVKEATAVSARDLTPWECEYRYLHANGEVRWLAGYSQPEREPDGC
TLWHGYVHDITEQRATHEALRRSEERLRLTTAAVRDGLWEYDTASGCIEFDARSHEILGH
AGRANCMDFADWCHAIHPNDRPQVLAELHQQVQAGEPFALELRLGTASGDWCWVELRGQA
APLQDADGERVIGTLTDITQRRADEHLRRALLDNAGAALVVTGNDRVVRLANQRAVEVFA
PEGQTLVGASMRVLYLDVADFDHAARHYSEMREYGSTWGEYLLRTAEGEQRWFALRGTLF
DPDQPEGQIIWTLVDTTDRKLAEQALTKARAHLLAVIEHVPGGVLVHNLAGVVEVANEEA
CQLLGLRSPAGALVGLDAQALQSLMPPEVLGHWQAAQQGAQVAELRDGRTLKFEQIPMRS
AGQVIGQLWIVRDITERRRHEQTLQHLATTDALTGLANRRAFMARLEAELEQVAEGGAPG
MVVMLDLDHFKRINDTYGHAAGDRVLVRLAQILRGQGLRQSDLPGRLGGEEFAVLLPGTT
PANALAVAERLRLALEQSGIDSGEGHIIRVTLSAGLAPLAGDAEHSLALADAALYEAKNT
GRNRVVLAGVPSPATA
>A0A5P9IMV6|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MIDRHGGNSHPPSSPSRSMPFTHDAPHAASSGDALLDRLQTPVWVFDIAQERMRYANAAA
LRLWEAETPQALYAQDFSATMSEATRQRLADYLPRLARGEVIDEHWSLYPGERAVSLHCR
CSRYVLQDGRTAMLVEGVDGASSLDASSLRALEAVRQSPMLVSVFDARGRLLTRNPAALD
ARREQDAFASCFAEADLAERLLQRLENEPRCSLEAVMRVGDGERWHHVDLSRATDPQTGA
PMIVMGELDITKRKALEAAQRVSKGQLEGVIERLDLGLLLEDEHRRVIVANQAFCDLFGF
EASPESLAGLDCREAAQASKGLFADPEAFVAGIEALVEARSQQSQELLAMSDGRFLERTF
TPLFVAEEYHGHLWAYRDVTRLKRQQDDWARQASTDPLTGLANRRAFDEAAREVARSVQR
GETEAALLMIDIDRFKAINDSLGHAEGDKGLKLLADTLRAHLRAGDRPCRTGGEEFMVIL
PGMAPAQAETVAGRLLRRIAEASIDADELPFHFTVSIGVTRFRPGDASVQAVTQRADAAM
YQAKHEGRNRVAVRW
>A0A7V8CD83|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas rhizophila|TrEMBL
MHNVPNLDEASQPLALAWAQTLAQTPAAAATLLASLSAESPPGLAHHFYDVLLEDPRASR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQADDSATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRKHIAQSPVQLASGQRLALTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDRVVLASDDLPDAPGRKALQRG
>A0A7H4PN16|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MAGKDPFASWHNDGLVSQDKISDVISKWLFPKPTVQTILHQGKIIGELRLTALDRLISYF
LGISIIVLTGSIFLASCIALLLTHSLHRGIVAALQSITEVVHDIRENRHFSRRVPEERIE
EFHLFAQDFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPR
>A0A6N7JHL5|diguanylate cyclase|EC 2.7.7.65|Niveispirillum sp. SYP-B3756|TrEMBL
MPISQTQGSGSLATVIDEHLRWLTQWHRAAFFGAEAGLSGPDAVPMPQAFIHWMRQAKAQ
ALALQPAVERLIALHEQLHRLARLMLTRIHAGEILSLAGYEAVLDRFDEFIQQCRRFERA
FSVAGSGIDPLTGLRNRTGMMEELMREASRFHRSGRPFCVALCDLDRFKLVNDTYGHDAG
DRVLVAAAACLNSGIRDMDEAFRMGGEEILILLKDAGLPEALGVLERLRQDLAALPVQLA
DGRVLHVTASFGAAEADMGIEPDRLIERADQALYAAKHGGRNRVECWTPPAAAALSA
>A0A736TE92|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWVTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7H4PN17|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSQAILVDGRQRPLRLMA
>A0A498CB14|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas rhizophila|TrEMBL
MHNVPNLDEASQPLALAWAQTLAQTPAAAATLLASLSAESPPGLAHHFYDVLLEDPRASR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQADDSATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRKHIAQSPVQLASGQSLSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDRVVLASDDLPDAPGRKALQRG
>A0A7H4PJG5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MLFDLDNFKDVNDTQGHDAGDKLLQDLASRLSFFRKTSETLYRLGGDEFALVSHDLTEEM
ALERAKVIREKISQPYQIYDSLIQIGACIGIVISDGESRTDYLYKCATWRCMKRKKRVPA
TFRYSVPDCFSASRRINPLKMT
>A0A7H4NLS7|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MPEREKNIHIQPSSSISRTHILPALLAIVAVSSLCAFVSPPLGPWREILTNPGMYIDLLA
LLFLLFMLWSSTKVRMNHVAVNWVRYGLLLWIAGGTFDLMDEIFHQPRWMGYYCEDLLRL
SGMLLSAVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKEGRRLALMIVD
IDYFKKINDTWGHLVGDEVLFALGKQLAKLTSDKVLPSRIGGEEFAIIVDGLSAQEVDEL
AQSILQNARAILINHDNPLSISIGVGLRHKDEPQNLFIKKVDDALYKAKNNGRGRVEWAA
>A0A7H4NK20|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKLAGLHPDELRRLQSLRASGLLNSGKEERFDRLTRLARTLYDLPVASVSLVGENTLHVK
SCAGLEVDTLPRDITFCAHTILQTDPLIVNDLQQDLRFHDNPLVTEAPFIRFYAGYPVQL
PDGATVGAFCLMDHKPRAFSVHEIQILSDLAAIVEDEFKVLDAATADELTGLFNRRGFMS
LAEYALLTARRRNEPASLVFIDLDRFKLINDTWGHEQGIKP
>A0A161YJ81|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MFYKNNLLRKKQNMIILLLILTILFLCGCEGKKSIAPKASQGIIDLSNWNFQKDGLAKLD
GQWELYRGELLEPKDFKNNNKKPLDFFKVPNSFVNTVNNNKLPKFGYGTMRLVIKTKGND
DSLYGIKTQSILSASKIWVNGQLVASSGTVGKDANTAIESFEHQIAFFKNDNREIELVIQ
TSNFNNVTGKIQSVFLGTDTQIKRAYIVNVASDAFIIGCLFIMGIYHFALYYKRRKYKAP
LYFGVFCLIVALRNVLVGERIIFDVFPNIPFNLFNKIAYLTVYIGIPFIVMFFKELFTEE
FSFKMVRLMKIVSLLISLVTIFTNIEFYETFLIYYEIWTLVLFIYILFITIKAVIKKKQG
ALMILFGFIVFLITAFHDMILHAGLLHTNSLIPFGFFIFIFSQSYMLAAKFSDAFVKIEK
LVEENKAVYIDELTGILNRRGFYEQGGNLFKAALITGGRSTLFFGDLNKLKTINDSFGHK
EGDEAIRSTAHLLKNTFGKDDIVARMSGDEFIAISVNKASEEEAKKIIERVNINFHKHNS
SSNKPYELSISMGYSICLPTVNTTFEELIHQADTMLYDAKTIIKNNCSTS
>A0A292YEK7|diguanylate cyclase|EC 2.7.7.65|Lebetimonas natsushimae|TrEMBL
MKEDRQKELFEIILNKTYKNLIEKLKINSYTKNFLKNKDFKFLIMNYKNFLNKNFELFLN
CNFSELKNEIIAYTQKFDNNGIEYSSYLEVINFVELSFLKSIFENINDYSFCNLESFFIK
INEFFNFIRNYSALSYLQDCIDREKLLLSEYILGTIRENDKELFNYINYFLNLTDNFLNF
IKNEDLKFNEKINLFNIKHRINSIEEKEAEKLTSLLDNLNYIIEQIIKLKKEKNYLLLIE
KYNEFMKNSLIFLSFIITHLAMVEIKKLKLDPLTKTLTRTNLESLILGIEDISIISNMPF
GLAFLDIDNFKRINDTYGHLAGDEVLKKVAEIIKNKIRLSDYLFRYGGEEFVIVFSAIKD
TETLKEKLDEIRKTIASTFIDVEKEQKINITVSIGGILVKLSKRMPIKNLIEKADELMYK
AKKSGKNKVIVDEYCKI
>A0A143QCX4|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MPVIIVVAVRMTASGPYRVREYTHARRPLFHAAAIVPNVSPSDHRQRSATPPQDLRGRRA
RRGEPHPWQGPGRHSSPEQRAADARRGRRAAAFGGRIATGPVAVFRRWLTTPHDFDWIFV
HRSTRPLHGLIKGVVVFGVGLNALVSMLMLGSPYGPSGTAEVTWVMIVFAAQISVIAWVI
FAPTPTKKAQFLGLLLFGDLGITSVILLDTPTSALIGTFLFALNGALCTFFLSARILLAH
LAFVNVVIAWIGVQAYLQGLWGVNDAVAAVLVASGSVSGVPVFAHIAWSLVSADARASEF
DELTGVANRRGLQNAVDELWDVARSRGVPVAVLLVDIDRFKAVNDRYGHDRGDAVIKTVA
SRLHALLGSHGILARTGGEEFVGVVVDTDGDLPDLVNRVTATVHDPADDVPVTASVGVAV
MTPDSPSWQVGPAAVTRATRAADSMMYRAKAAGGDRVLTTRV
>A0A0H3FQD5|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)|TrEMBL
MNDESKKYISVIFKEWLPLYDSLTPAVKEVLKNIAEEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLALWVKEILTSDKAQLPALAERQYQIGSIHARIGIPAEAVLRGARQIK
AGLIEYIRSHVNDRRIAVDAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPMEYGKQQAALSGWENTAIFNIVSENKANTNATLLSESEFGLWFRHKCVRYFNKNSQM
DEIAALISQVDDLLIGWRASASVMDYKNTQNLIQGIHIHCQQIGSQLGVIFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKGINDNWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGVSEAFTILDRLRKKISQLAFNVGGDTQIPI
TASIGYAVHSGHPDYNLLLRDADNALYAAKREGRNCVKMHKGRV
>A0A379MYR8|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MPSVARRVTLVVAGVWLVLVTGLSWWMSRYIMTERLSDLAASAEYDTRTTARIVDRLFTE
MSSVANMVAHQSRVIQLATRYRVDPPDLASLTRQQRAAYFTRDPLVRSVGDFMNSLSSDL
RYARIYMNNLSDDTVTASNWAEPDSIVGMIYRERRYLVDALQHGKGQMFGIARLNRTPSY
FVSSRIEDADDVTQGSVTVKFDAPDMALYLAGQHIALIVNRQGRVTTSSSAPFMLRNVAA
LLPPDILQPPDGDEDIGKPMDIRAMTGPEQAGQWQIDGHLYLLRRQPLSDRTYQLLTLVS
LDSLAPMRRQHFWVAGLVAALGLVLILLSGRVAGQMVLRRQEERYAANYDALTGLPNRRA
ILADLGQCFALAKRTRQSILVAFIDLDEFKTINDTYGHEIGDKFLVEVARRLSAGLHPGD
VPGRWGGDEFIVIRLAAPSRPDAPDEAAAVMRRQLAPLLIGTYVFAGCSFDYPGASFGVA
TVDPSASSLQAALQEADRLMYADKQARRALRLRVTPRPSVRSEPVDLIAGRASRPESAGS
ASPPLSGR
>A0A235F2A8|diguanylate cyclase|EC 2.7.7.65|Thauera propionica|TrEMBL
MYKLLPPETTETIENDWLTLFDQAPLGARTAVRDIIAAHREAMADAFYERMMQDPEARTF
LSSEVVHERLHASMQRWLTTLFSCETREQFLTAMAMQRHVGEVHSRVDVPVNIVARGARV
LKNRIGNHLARSPLGRDELVEAVIYVDSLIDLAFEVMSSAFVASHERTARIDEAYRSFSS
GQNMSLERERQRSALLDWENRFLQAVMTGLPGDELPRVSSSSFGLWMQHKASAVFRGASE
LTAVRTLMRSVDETLLPLCAQQLGAGNMNEVRHLLKQVQAEVGELKFLIESMFEHLVDLE
SGKDALTQLLNRRFLPAILARECEIARTEGKPFALLLIDVDHFKHINDAHGHQAGDRVLQ
QVAAILQNSVRSGDFVFRYGGEEFLIVLVEMDHTRAMRVAEKIRTRIAAETLLISNGGQL
NVTVSLGVAMHDGHPDYQRLVNRADSALYRAKQGGRNRCEHDSLETKS
>A0A8J7V3Y2|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MNYKTDEIDFSPFNADEVLRALCSVLRTSKHLSFSYAGDIQSLIDRIGRVFYAGRALIFV
HSSDERPQVEIFEYVKSEKAALAFQFATPFGQRFAAHLVGLAQEVTMVEEPSTFAAELDS
EYKEFFGKLAENLGPERFYMIPLRLLSSDVGSTTSEKRAGLLLLQESDAKVRWNKLVLDS
LVTIADHLAKLAQVESLNCRLEAHEKDDAATGFLNRRGGVVALTEEIERAKFFGDELCLM
LVVVDSLRRSDATMTAAQSKELLAAVSSVVSKFARPVDVICRYGHDQFLLSLPRMAVSEA
EKVAEHIKSGINGALLNVASKQKQANHGKPFDEAQAGVAGQPLSASIGVACMSEDGKCFD
ELLAVCHDLVSQAQSIGGNVVKVRKKS
>A0A8G0UQV7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MPVFLPSLKARIALITTVLAAVFGTGIVLTSLFAAHRDLQDVLQDEQDSIVKLSADQLDT
AMEDRIMLLRQQAAQLGGLFGTARGAQAPAAMAQALAQVRRAIPVPGAFNSLMVVDARGT
ALGDSGMVTEVGDRTYFREAARTLAPVISPPIRARTNDRLGVIVAVPVLSAQGRFAGLVG
GWLDLARSNFLVEVLHNRLGTTGFYCLVSAGSRPVYIQHPDPTQARQPARAIGDTCGQDD
RAATLEFLTPTRPVVSRYLMSTTGWELVALLPAHEAYAPLHRMQQRFLILAGLALLLVAA
SIWLAVRLLLAPLTRLHEVVRDSASDLSAFERLPERQHRDEIGDLARAFTRLMRDVRERR
QELDRSERRLRAVTDTLPSLLAFIDTDERYVFNNIAYEHTFGLTLEELRGKTVREVLGET
RYARAQPFLQRALAGAVVTFESEENEPEYHCMETSYRPEWSADGSEVVGVHIHVQDITPR
KLETMRLSHISSTDHLTQLLNRSAFESRLQDAMARCRESGGMMALLYLDMDRFKAVNDIH
GHAAGDLLLQAFAKRVLGCVRKQDAVARLGGDEFAVILESVGHAAAARSVATDILCAVGQ
RFHFEGMFADIDVSIGVALYDGGPMQERELMRLADVLLYRAKGAGRGRYEIGPPELITAD
SAQ
>A0A5K1IG67|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCTIVLIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYISFDMIWTLSDGV
DGTLGIAVNWISNAVSFSLFAIVCLIWFIYSETVQGSRLLTSRYRVLLVTLPTALVVVLA
FASYWTHALFYIDARGVYRRGVAYMIQPIVSYCYVIYTSLHAFVHSLRVESLRKKAIYRT
LAFFAIPALVGGTLQVVYSVPGLCVGIMISMLSLYIIYQEQLISTDPLTGLNNRNRFETY
MLSTFSNVDQAEDVYLLMMDADGFKQINDRYGHVEGDHALQVISAALKEVCSASGGFIAR
YGGDEFVVLQKATTEQDIMHLCATINDELARAEVPYLLRMSIGYARVGDDVDSWQDLLRA
ADAELYRVKREKKQAGVQIR
>A0A6N3DGV8|diguanylate cyclase|EC 2.7.7.65|Streptococcus lutetiensis|TrEMBL
MILGKVSDFLIKHQRLLTYLSIFAALMLLTYLVYDAWIDHDNPTILVTLVVILVLCTIAS
HLNRRQYILSHFILESAKLINVYAVDLDYRFIAVNKNNIRLMEEVFHFTPKIGDFPMNYL
DGEEAARLKVNVDRAKKGETFTFMDTIKAGDKTLYWQNMYSPVYNNRQKVIGVFCCVLDV
TEQRVHELEIQKIAYEDVLTRVHNRRYIELAFEECLMRKEERITVIISDLDKFKEANDTF
GHATGDKILIEFGDILMKIMPESAVIARIGGDEFAVLLPGVPENQAEFLIKLVQAEMTLK
DMGVTASLGAYTDSYQSHKNFVDFCAIADKKMYENKSQKGERR
>G2DDX8|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MRKLIIKLGRFWVVLGITLVSILLSLTAAWVMMEVTGVPQQDFLPRALPIAVIVLALVAP
LVSWYLVGLFIRVHSLEAEMRQLASFDELTGVRNRRSFLDLASSYFEVARRNQQVFSLLL
LDLDHFKFVNDNHGHLGGDAVLRQLGRQFLDITRKSDMLGRFGGEEFIFLLPETGADELS
HFTERLHGVIRDDPIDWEEQQIHVTASIGITVFDQENCPESLNLLIKQADDALYRAKREG
RNCSCRYSPTLAQMRWSDEPKRVNGETL
>G2DCY9|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MTKKVFADLAIWMLGFGIVVGIIFPFLLLMLEFPEAEVIRPGFFAITLAAGVLLAMVNYL
LVYGVVQPRLNLLVEHMQSTEGMIHNATRQQSWGHCDAKSCFVPQDSDDEIGATAAAFNQ
LVAELMRSRKLDNAASEFSHALSSKLDLDELNQHALDLLIEHTEAAAGAVFVEMQGELQV
AANRGLERVESIAQSNHLLNALNSGEIRQLDLPKEVMVEGVLTSFRPSQILLIPVSFKQQ
SQGVVVLATGTAFPRDALWLLGLVRQGYGLALNNALTHSQLQHIAAIDPLTDVYNRRFGL
ARLHEEFGRSRRSGSPFGLCIFDIDHFKSVNDTYGHLSGDKVLAGVAEQAREALRSEDIL
IRYGGEEFLMVLPGAATSQVAEVGERIRKRIEEMRVENNGTSLSVTVSVGCSAYPDDQVE
DEQTLIGHADEALYQAKAGGRNRVVRYRPATSSE
>A0A380SX83|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MPPRSALFSQRSLILTLLLLLACGFLSTSLLSYFASRSSIRDSIINTELPLTSDTVYSEI
QKDLVRPILISSMMAHDTFLRDWALGGERDTAQVTRYLGEIMRQYQAYTAFFVSSNTGVY
YQAKGVLKKIDPQEPRDAWYQRVLKMNTPYEINVDLDMANQDRLTVFINYRVFDYDGKFI
GVAGIGLTVEAVIRLIDDYQQRYQRQVFFVDQQGLIVLTGSNGGPHGARTGQSLVELDGF
GQMPQPVSGSHEYRSSDGHSHFLNVRLVPELNWYLFVDKREDGAMDAIRQSLYLNLAICA
MITLVVLSLLNAMVKRHQDNIEALATLDSLTGLPNRRGFDLLAAQALQEAQREPKPLIAL
LIDLDHFKALNDTHGHLAGDEVLRQFAQVLEECLRHADIICRWGGEEFIVLLKDTDSHSA
LAVAEKIRSKTEALAFTYAEQPIHLTASIGLSNLQADDTLHSLIARADHALYRAKQSGRN
RVCAEMPRSDHEQPRS
>A0A1V0LCE9|diguanylate cyclase|EC 2.7.7.65|Kosakonia radicincitans DSM 16656|TrEMBL
MRQNSVVKQPRSFITLKRYFLPARVVNLCFLIVMVCSTILTWREVIVLQGAYVASQRSEL
ENVSNALDMQMQSGVDRLLFFRNGMQAALQTPLGFKVLNNVQQEFGLRRTQSQWQIGLDN
TRTLPIYGVSDYFVNQSDLLNRDDERLPAELTAAMELGYLFRLSANASMLPRQAYYVSRA
GFYISTNPVESEEKIVPTYYRLLMRPWFRGQQQQENRARGVRWYTDQARQGSVTRGFVAA
SVPLDYQQYWYGVLVLSFPISDINRLLVEAREEQEGGQYLLYDSSFNLLTSTLTEQGAVF
SVNERNQLLADMERDTLGGIHLGTRYVSWQKLKQFGGVLVRIHTLREGITGDFGRISIAL
SLLWLLFTGMLLFSWGIIRRMVNNMYSMQNTLQWQAWFDPLTRLYNRGSFFERAKTLSEQ
ARVSNLPFAVIQLDLDHFKSVNDRFGHQAGDLVLSHAAGIISNTIGGQDVAGRVGGEEFC
ILLPGSTLEQAARVAERIRARIKGKEILVQKDTTLRITVSLGVSDASENGDYDFESLQSV
ADSRLYRAKNNGRNQVCSTDGAPKK
>A0A7Z0BRL1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas flavescens|TrEMBL
MQAPPHSTEELGSPKEGAVMVLLVDDQAMIGEAVRRELLGEGGIDFHYCSDPTQAVAVAE
QLRPTVILQDLVMPGVDGLTLLGAYRARPSLRDVPIIVLSTKDDATVKSTAFASGANDYL
VKLPDTIELVARIRYHSRSYTALQQRDEAYRALRESQQQLLETNLVLQRLMNSDGLTGLS
NRRHFDEYLEMEWRRALREQTPMSLLMIDVDFFKSFNDSFGHVAGDDALRRVAGALRGCC
SRSTDMPARYGGEEFAMVLPSTSAGGARLLAEKVRRAVTDLGIPHDKPEPGSVLTTSLGV
ATLVPRAGQTSLQLVNLADRGLYMAKQAGRDQVGLVNDTSSLA
>A0A2E8C8I2|diguanylate cyclase|EC 2.7.7.65|Pseudomonadales bacterium|TrEMBL
MPRLSVEQLSEEWGLLNQKFSQQSRRFVLEFCIRHAVDLTETFYSEMMADPAASLFLSHD
QVQGRLSLSMRRWLEGLFDSEDEVALARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIALLQEDCELSDREHLDAARLMSDTVDLAMEVMSHAYSTSHDRNSRNEEAYRLFSVTQN
IATEKERQRAALFDWENQLMFDQAVGQSGEHLPRILASEFGLWFRHKGAHAFEGAPEAQQ
ILDGMERIDDVLLPLFDQDPAERIARLRELRETVKAIRFSLDHLFEQNNELEAGRDVLTR
LLNRKFLPVVLTRQVSHARSHGTPFSVLALDIDYFKQINDSYGHEAGDRVLQQLASLLIN
SSRAGDYLFRLGGEEFLMLLVDTGLDGARRVAEKLRRGVEQEVFRLPQDRTLNITLSIGV
ACFNGHPDYQQLMRRADDGLYQAKHSGRNRVVVVE
>A0A6G8RXD8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter shaoyimingii|TrEMBL
MNEEYIAQMSEQWEQICNEYSATDLNYAFEFICEYSSDFVGEFYKEMMIEKDASFFLTDE
IVQSRLKSTFEKWLYESFNVPNALNFDEIVKKQFVAGDVHARIGVPSWLIMHGIRQIERK
VFEFLAIDAATNALKVAGYIVQILAFASEIMCRAYEAKVEVHNDIKHSYRLFSAMQDVAV
QKDKQRGSLLNWENELMFKVFSNTLNIQHTLLSKSEFGLWFIHKAAYAFASTDQVEIIVD
KIHKVDQMCEIINQQLDPEQSIQLIHDIREKNRQILHLVEQLFQVAEYINSGNDSLTQLL
NRRYLSTIVSREINLARKNQSPLTLLAIDADYFKKINDRWGHDAGDKALQMLADVIVEHT
RGSDYAFRVGGEEFLLLLVDTDIQQAEIVAERIRQRVAQSTVSSIAGANFNLTVSIGLAK
YNGHPDYQRFLDAADTALYAAKHQGRNNVYVA
>A0A1C5QH03|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGKFKKILFQDVENPNESADGPITLRISALVMMIYLLIISVTLVMVHHVWWMAGNLLFVA
IYGYLLYLTYENHTRTALILYNIVMLGAVCFNVMLIGWDSGLQHFLFTLVLLDLLFTYLS
KWSQGVVVMGLCAARLGLYFFCREHGKIVQIDGACDIFLQVLTTVVVFVLLYLSGLMLSK
DSQAVERKLMKYNNELQKAANTDTLTKLWNRHYLMHYMGKKVEHPDDFLSIAIGDIDFFK
KVNDTYGHECGDEVLRTLANIFKKEMEGHGVAARWGGEEFIFLFEGANGDEAKILLAHLQ
NAVRKATITYGEVQLRVTMTFGLVEYDTKLRLDENISIADERLYIGKENGRDRIIY
>A0A1C6DL05|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTTNMEELEQYKIRLDMALKTANLCIFEVDLLQQKYTYFANSEAIFGIKAETILQDIDTY
SALPADAYQKAVSNYFAHPDDHATIDIAFQNIYQGHSASYEARMHANNSKYKWCRIDVTP
IMDAHKPIKMIGVITDINSLKQETLALEKAVHFDIFTGLYNKPSFLEIAHQKLMQKPHLQ
YAVIVSDIDNFKLINDTYGHLAGDDIILSIAQHLQTTFRNQDIIGRFGGDEFIIFVNDIP
SISWLCEKIQSLLICSVTTEIACSNSIGIAMYPQDANNLETLIQYADKALYQAKKQKGTY
SFYQK
>A0A1C6HMK3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDRLDKFHLVQDEYRKLDAQWLRLHVVILSLLAALVMLAEIAMYFILNTDNLITSSPQVY
LLKYLLFPTACDGICVVLAWWAVNTPRLSEKAKRYVLSLAFSLAAFVLSFVHETFLNAYS
GFAIPVILTAFYRDVRLTSVTAGTCVLLQLISAFFIHWDLDKVYGADYYAEILVALLILV
FVYIICFVIIRFDNKRHLIILKNEQERRRLQRELLTDDLTGIYNKVALRDFLEHLDEREK
IANFHIVMMDIDDFKRVNDTLGHLQGDIALRIVGKAIHNHCSINTAFRFGGDEFCLLFEN
MSSDEVHSRIQSMQRDYQAQTQVEISQSITLSAGIAAGRKGESASQLLERADQALYRAKE
QRNAIYLAP
>A0A1C5PKG1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEVRSKNYVRKDDFPTSLIMIDCNYLKEVNDHLGHEYGDLLLQRIANSIQETISKESIAI
RVGGDEFLILCPHHDHQQAEKLIEQLQESFHSKTDNILKLDAAFGYYTAMDDTLPFKEAF
YIADKNMYAHKKIIHQQRNHK
>A0A1C5Q2S7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRKWKAWLFALAVLIGIGTIGTVSMKAEAQNLNQGKRVLFISSYSYGWDTVQTQIEGIKA
GVDENTTIDYEFMDTKRFRTDEWLNMFHDMLKYHLENTDPYDVVIVGDDAALQFAMEYRE
ELFPEIPVVFEGVNDEEYAMKAAENPLVTGIIEKLSVEKNIDMALKVNPTADKVVAILDD
SVTADAERKNFYSAEAEYPELEFSEINSSELTTAQLQQAISKVDDKTILIYIVMSKDGSG
KQYTSDQAVRMVVNYSKVPVYRMVEAGIGDGLLGGNVVSMYKSGEIAAQMAMDIANGTDS
AEINVVKDSPNIYCVDEDVMRKFGLEASQFPKDTEFVNHRESFFARNREALIPALILIAA
LNVIICWVCFDNYRRRKLLQELEQARAIMEAASQHDFLTGLPNRSKFMKDLEQMIDAKVP
CTVMMLDIDNFKKINDTYGHTAGDEALQQVANRLKEMQSQILTSYRFAGDEFILILRSSQ
NMLVEKTAYQCRQVFTKDVVLCGTKRKIGGSIGIASYPKDTDNLEQLIVCADDAMYQVKK
NGKNDFAFYKKPEEEKTDNTQ
>A0A1C6DAH1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLENYVALSITNILAMLLLAFVVGRNNLLNRKMKRFFSTAIFCTILVILAEIGTSVFGQP
VASFSLPNMFFNVLGFSLSPFITISLAFVFNHKNYRNIFYLFLPAVTNMLLAMLSPKFGL
IFSISQQNEYFRGPCFFVYVAAYIWSMTILFKETLYIAKRYQNKDCFALLLLFLFILGGT
SIQVLFPSIHTTWSCVSLSLILYYAFFCELKEKHDILTGLFNRRAYEYEIQHLESLGYGA
IIFFDVDDFKKINDQFGHQYGDQCLSTIAGLILKSFSGIGFCYRIGGDEFGVLSDKADEI
DILNAISLFINNLNSSQEQDCNLPLVSMGYSIYHKSEGSIEQAISKADAQLYRYKKLHKQ
ETKEPGKTNCNFSCSLTERTPH
>A0A2S9YJU4|diguanylate cyclase|EC 2.7.7.65|Enhygromyxa salina|TrEMBL
MSILAEAARKLRVRYIEGLPAKRRVVQEALTARSLGDPEADGTLRRIAHQIRGSAASYGL
LEIDNAAYRLEYAETTAELEQAAAELIVALHEVYRAESSPYMKILLIDDDPAVGPLLEGL
LSEERISLTQVLTAAEGHEELNSGDWSAIFVDLILPDADGRTLLTRIRAAPSHRDTPLIV
LSAKTSSLVKNECAMYGIDSYIEKPIDPRTFAVGIASVLGRARSLQAAAYDDSLTGLPNR
VGFRRAFEPLRLLAERNGSPLSLALLDIDHFKRFNDDFGHHVGDRALVTAAQTIKASLRH
SDLVGRWGGEEFIIGLPETGAKAAVELLGRAARALREHEDFGAQNPMTFSGGVTELEPGE
TLDFGLLRADQLLYQVKRTGRGKSICELEPVADGRPRLLFAEDDPGVASLIMRDLSEDFE
VTHVGDGGEALELSARERFDIVMLDYQMPRRNGIDVVRELRTRPEYRDTPILLLTAIGSD
TAVEQAFAAGADDYITKPHRRRALLARLFRHLGRSAVALSDDTPRPVPQTVESMVTVVVC
DFVDVEGPGAGLPAKRLRPVLDGYTSLATKILVRRKAEVDKLGGHRLVAVFGAPVLREDD
ARRALKAAVEIQQAVRQMASVSRPLGVRVGLHSSLVTAASVAGQRYVQEGALDGVVRVAR
EMATTVSAGAIVLDAKTVEQSSASSSGSLNGPVPWQVEGRSVELYRLRWQ
>A0A7X0IPD6|diguanylate cyclase|EC 2.7.7.65|Rhizobium lusitanum|TrEMBL
MEIQTHLPSLVRVLGQVAIIVYAYSLVTRTIERGILKSVAVGLLFGLGGILSMSDPIRFM
PGVIQDGRSILLVLTPIYGGIVGTVVAAFMMAIFRYLVGGLGAVSGVAGILIVATAGYVL
TLLPRQLTGTGWRRSALFGLATTTSLVVLVFLPWSVARELLISAALPVTIVNILGVMLLS
DLLEKESYRIGIQRALENEATLDPLTQLPNRRVLQREGDRCSKEAGMRRVPFSIIMLDID
HFKKINDNWGHTFGDTVLARVADVIRRTVRKTDIAARYGGEEIVVLLPNTDMRAAGIVAE
KIRNDIEATVLMFGQETVHVTASIGIACSFEPSTDFKYVLEAADKALYRAKAGGRNRVEL
AETA
>A0A739C451|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae serovar 48:z4,z24:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTILSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLHLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A3P6M9L8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCMFGYCISE
ASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVL
AHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFA
LRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADIS
QHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQ
DVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELR
NVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAIDYIRKNGGNGWQFFSPAMN
EMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFI
PLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMH
AWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSFLFPPPTRRRNSRLDEQRVT
AENLTNSSRPHSRVFI
>A0A2X2IIA6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGD
EFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERL
YVNKQNKNSRS
>A0A8H8ZI40|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDLGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKTLREAKS
EGGNKVIIHHI
>A0A7W9TVJ7|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia bannensis|TrEMBL
MQRSVKGTAAHTRPDRFSGIVMKRPRLVVTLCFIGAMLLLIAVGLRQLYNMTRNDLHSRQ
RDLEVRAVGVDALIEAERRRLMFLRNFAEHQLSAHEQPSPAEQTAVMKALAASTQPVWHI
AGALDGPNVYGTNAAGLAGLEGFQRDSATLPGDIALARAISPLVQISQHADAVQSTVAFI
SSNGLFVIAPENQGRTVPELLRRFSTMNYYRGQLPASNPARDVLWTPVYTGLQKGESIST
LSAPIYAGNHFRGAVVMDITQSRLLSLQLSSGQTDDDDENNVIEFGLLNSNGHVVYFRNG
ALTEQPPAGFNAALLRIAQTSADRWMQKGSGYVEHRGTYLLYQRVGQTHWMLLAPTDNTE
LTLAAARRVFNSPVIAAWVVLILLLMGTLRIVTNIFSHYVEASERLEMLARSDPLTGLAN
RRRFKEAFAQALERAERAERADHNSNDEGTQATPARMAVLMLDIDFFKRVNDRYGHAAGD
RVLSIFAHLLHANLRSVDLPARVGGEEFAALLPDADLASAAAVAERVRSAVEAHARDSRA
SAGSADAIAFTVSIGVAASPEDGAADYEALMQVADRRLYLAKESGRNRVVHADPQKH
>A0A0S4I449|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MPNTKHGLRLDLRRLILVLCALTALVMLCASYFASYRVQRQLLINHALEANRVYATKLAT
ITETFIGNALQQLQFSAGVQGRQLSDAVALQVETDRVLAQSMAFNSTFVIDADGTLLSVS
PAPLRHLVGGRMRSPGVDEALHLRRALVSTPYVSAANNLVVTLSQPIIDKQGRYLGYVGG
TLYLRERNILNSLLGEHFYKDGSYLYVVDHQRRLLYHPDNQRVGTVVQGNALIDQLPTLP
SGTVALTNSQNVEMLAGFATVPSARWGVVAQQPLSRTVAPLNTLVLNVIGTSAPLALVGS
LLLWWLALVIARPLWQLAASARMMDSANTAEDLHRVRAWYFEAAELKRALLFGLNLLHER
IGRLNREAQTDPLTGLINRRGLEFSLSLLEAEGRRFSAIVMDVDHFKRINDGHGHDTGDA
VLRQLAHSMRRCCREGDLLCRTGGEEFLMLLPGADLAVAASVAERLRATIGDTPVAPVGA
LTVSLGVAHWEGTGDAAGTLAAADRALYLAKQGGRNRVVVA
>A0A7Z7HRU4|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MNDKLPRTAVHYLVEMVDHFVHPSLRDVPDMLNRARILIASMVIMAGCALIALITIFLSK
FPLHSNISAATLILPMVLWFNYAFIRFWRHGNYAQTSKAVVIVLLVTLIGAIGISGGPLT
SPVIYLLVVPVLTAFFFGGQVLGNRISRITIALLAILLLMQWLGVPFIQTVDAAEKMEVL
SLVIALLGVSVISAMAFIYEYTAAVLKRERDTEREKFMELAKTDPLTGLANRRNFDAMLN
ERMSLYGTQNPPQRFALGYLDLDGFKPINDTHGHAVGDEVLCVISSRMQGVLRDSDFVAR
HGGDEFMIMLDMIGDREALKMMADRLLSVISRPIKTSAGIVSVTGSLGFALYPMDADEIE
ALKKSADSAMYEAKRSRDTWRIYRDASGKLAADTAAS
>A0A1V5SN31|diguanylate cyclase|EC 2.7.7.65|Candidatus Atribacteria bacterium ADurb.Bin276|TrEMBL
MIEYNYLFSIGCLVTATLAIALSLLSFWSSQFTPHARPLGFLLLFSSIYAFGYAFEIMKA
DPEWFFLWLRVEYFGLSFIAGSFLWLSVEFTGRFKAHKPIILVALAGVSLFFLIVVLTND
FHHLYYTSIEVDYRGLFPTAALGRGIFYILNALWFVGSFLLSFILCLHHFFRTTVVLRKR
TLTMLIAVIICLVNYFIYILKVIPWSLDIGPLIITINGLILSIAITRLAFLNISPIAREQ
VFESMQDGVLVTDPQGRILDFNDAAQHIFPNLTRENVGHHLPTLVPELKPYLSTENISKF
NPLSIQKGDAVLFYEARKIPIKNKQNKKIGIAVYLREFTEHYKLLQKLQEHAEKDWLTGI
WNRRKWMNLAKTELKRAKRYGRPLTIAYLDIDHFKLVNDSLGHEGGDTVLIHLVKNISSQ
LRENDIFGRIGGEEFIILFPELDKEKAQMVTQRLLMTVCQEEIIACEQKVKATISIGATI
WDGDNEVSLEELIQKADKALYMSKAAGRNRSTFI
>A0A8F8CPK0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter septicus|TrEMBL
MISNLYKSKSLHSLFRKSQATIFAITFFICTFTFVLISIFTIETYAKQNLNILGLTVSER
IQPALVFKDQLTLQQILNEYTEQHSIRTIHIYDKNHLELASSSKPPVYYSQLQSFLDYVF
LKDPIKLTVYHHNNKIGELVLFGSSEKIIQFIITILIGLAIAMIFIVIALWWSTNMTYRY
IMQSMRPLTQIAQVVSDQKAYNLRFPNNNIKEFQDLNDVFNQLLEEIQTWHTHLQNENHQ
LSFKAHHDHLTQLPNRSYFYQELVDLFEDHQKRQNSALMFIDNNNFKQINDQFGHLAGDA
VLEEMAKRLKSKLRHQDFIARLGGDEFAVILQSIHQVEHLITIAENLIASSKAPILFEGQ
SIEFSFSLGIAFSRFATTPEDLIMQADQSMYKAKHLTHHWFIYKP
>A0A0H4W200|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MKLPIDTFVLRWKETCAPYSSDILALAHERVDRQAHELADAFYESMLADEAAAYFLSDQL
VHQKLHASLQAWLRSVFGAAVHHDYEAAVAFQQRVGQVHARLDIPIHLVMQGTRTLIRRM
RATLADDTSVADALRWPLSSYLGEIMLFAIELMSLAYASSHDRNARAEEGYRLLSLSQNI
GTEKERQRAALLDWENQLLFGLSVGDSAQSLPRLRKSEFGLWFIHKAEHAFEGAKEAEDA
RAQIEAVDRLLDEHPAPPDRIRLLHAVRDATKTIAYLLDILFEKANHLESGRDTLTHLLN
RKFLHVVMSKEVAYARKTGSPLAVLMVDIDYFKNVNDEHGHDAGDFVLQQVATLISTYSR
GGDYTFRLGGEEFLVVLVDANADQARHVAENLRQRLAGRMLALPDGSQRRVTMSVGVAAH
DGHPDYQRLLKRADGALYAAKARGRNTCVLAD
>A0A3N2RVQ8|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MKATTPTPTGWWSKLARRVKPERVVNICFVVVLFFSTLLTWRETIVLEDAYISSQRNNLK
NVANDMDAQLQFNTDRLLFFRNGMQSALQVPLAFEVLRTAEQQFERQRTQSDWQISLNNN
RTLPLHGVSDAFVEHTNLLSRDNPLLGNEFMATIELGYLLRLSAMTRQHLARFETHMLYV
SRAGFYLSTDATQQDSITEYYYRLATSPWFIQQSQRDNPNRGVKWQTTFSRDKTPAAQTV
TAAVPLDYEQYWFGVLAIQLSVNEMTQFLTQSVEGEDEGEYQLYDRRMNLIASSESDASK
RTQLSQEIQAQLAHAYEQQNEGSVRQFSRYISWEKLRNFDGVLLRIHSLEEGVRGDFGSI
SIALTLLWVLFTTMLIISWIVIRRMVRNMSTLQDSLAWRAWHDMLTRLYNRGALFERASK
SLAACQKAGESLAVIQLDLDHFKSINDRFGHQAGDRVLIHIGRVILNKIRKEDIAGRVGG
EEFCLVLPNTSLAQAAVIAERIRESINSREILISRNQTIRVSASLGVCSSDELAQYDFQT
LQSIADKRLYLAKTSGRNRVCAEDGEDRDK
>A0A1V5ICJ8|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MALERARAFRALQGRTATDVVTGLYGRWYFYERLYAEVARARRYRQPLSLVMAELDGDDL
SRARGRPFRDAVLAATARLLLASLRDKVDVACRLGVGRFALLLPSTPPGPETAGLVADRV
RRRVGGTLLADDELGELGRFTMSLGVAGFPQDAEDGDELAAVAGDRLARAAAIGGDRVEP
PLPEPEEEPEGGAPEGDSD
>A0A5F1E126|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4930|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMSSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A5E6ZE69|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDNKRGKGLSFAKRIYAPRVIGSGFGSIGLMAALYPLDRSIWVWPLLLLNAFVWPHLAYQ
LSSRATYPYRAERRNILIDSLCGGFWAAAIEFNPLPTVIIVSMMTMHNVAAGGPKLLVRG
ALAQLAGALVALLLFGFAFTPHTTSLQVYACVPVLILYPFAVGMVSYGLAITLAEHKRTL
STLSRTDSLTGLLNHGSWKDLLQLSFQQSLERNSPATLALIDIDHFKQINDTYGHIVGDS
VLRQLSKELKDNLRTEDLAGRYGGDEFCVILPNRTLDQAREIMERLRHVIDNYQHADEPG
LCVSLSIGLATCRPELLQASTWLNEADKALYIAKNTGRNKISVGAADTLAESQLSNDPV
>A0A5E6SIR2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLFRSNSRPTLGSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKSAANESLALIASTEEVADAQVLDSQGQLLAHWQRPENGLFSELEMQITR
AILEKPISLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKHNERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRIRAQLREEDLVARLGGDEFAVLLTPLHKVEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVYPDHGATPGALLDAADAAMYQAKRLSRGAQFTAGAEHPVDSVQT
RS
>A0A0M7AE93|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MLSTEIGASQKETSKAPTGHQQSDAPAGKARLKRIHKLSRPFWASFIIGAVSLLVFAAFL
VNALDRQAITSSERVMGSVLGERLDRLSELTLEYAFWDESVDRLVNGFDEDWIETTFVDY
IYSDLGIIGVHVLDGENTDRLHVYEDAVTDGTSMKRYGPDAEKLINRARRTPTNETPIPA
TGFLGAIDDLYLASAARMTTYDAETDTSTDHVMMFVRPLDDEALADLGEKFQLPGLQITT
EDPSYFQAHWPIRAEDGTTLANFVWNPVLPGQRLLPPLALGLIIVYAGMMIAARAFLKQA
MHMVSALDAAKRRTERAKELLAHQANTDALTNLGNRWSFEQTLDTLSAKADGTKEFALVC
FDLDRFKTINDTLGHETGDEVLKYVGETLSSLTYPQDKVFRLGGDEFVIVFGLTDRERVL
AVAKEAISILSQRVTLNGHSCHFGASAGIAYSTEPVNLLRRADTALYASKKKGRGQVTVY
IPDSTDTSAQRLPATETL
>A0A5E7FN57|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRLFKPGSRPTLRSVIGRGHLIVALVGVAMASISLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKAAATEALALIASTEEVADAQVLDEQGKLLARWQRPETGLFSDLEMQMAK
AFLEKPISMPIIHQGQDIGSILLIGHGGSLMRFLLSGLVGIVLCTAASAWVALYLARRQL
RGITGPLRSLASVAHAVRSERAFDLRVPPADIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNANKLNERVAVLFLDSDRFKQINDTFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLNKTEDAERIADKIIASMDVPIPL
PGHTQVLTTLSIGIAVYPDHGATPGALLNAADAAMYQAKRFSRGAQHTSGSEHPVADVQS
RS
>A0A379J1E7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVHETDSPIPTTPDSTDTSRPAAATLLALMHAQGEVERLSQREQLLSSLLVSVNAVLWAI
EWETRRVLYVSPAYERIFGRSASLLLAEHRGWRDSIHPEDQHYAEHSLAQVLELGAVENR
QYRIITADGQIRWLSDKCFTNQQATPGKPLIVVGIAEDITEKKHLELELQRLATTDVLTR
SSNRRHFFECAHHEFERACTQGLPLAFLLLDIDNFKAINDTYGHLEGDQVLLRIAESGRG
VLRRGDLFGRIGGEEFAAVLPGCEPERAMQVAERLGQEVRQLEFSHDGRPYGVTVSQGLA
SLTGADATLDSLFARADAAMYEAKRQGKNRVIVG
>A0A109KR57|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRFAKGRPTLRSVIGRGHMILALVAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSSAATEALSLIASTEEVAQAEVFDDEGKLLAQWVRPNTGMLSQVELQLAHAL
LEQPINQPILHQGQTVGSIHLTGHGGSLLRFLLSGLAGILICTALSAWVALHLSRRLLDG
ITGPLQSLAAVAHAARSERDFDRRVPPAEIAELDSLGSDFNALLGEMGAWQTHLQSENET
LAHQASHDSLTGLPNRAFFEGRLIRALRSAAKVNERVAVLFLDSDRFKDINDRFGHAAGD
AVLVAVADRVRAQLREDDLVARLGGDEFAVLLAPLHKAEDAQRIADKIIASMDAPIPLPG
DSQVLTSLSIGIAIYPEHGATPGTLLNAADAAMYQAKRLSSGGQQTAESEHPVANVQHRS
>A0A5E6V1N2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSQSDTRATVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGQEPELNR
HLDRVVNDFDYFPPESAAKLFREYIIRDELADARSGQQDAINLVDDMERDVSRSVKGNQD
FQASLGQYLQMLEEPASERLPSILTQLQQSTRLMQGQQEHFLAQLQSAQHEIKSLRDKLE
RAQLAATLDGLTELLNRTTFNRQLEQALSNVATGVALVMLDIDHFKQFNDQYGHPLGDRV
LQHVARVLRDSLPGEAFAARYGGEEFCVVLKDCPDLAAAGAFAERLRLKIQSLRVKARGT
DTVLDTITASFGVAHAQPGDTPESLVTRADDALYQAKRNGRNQVCQQTDVAVGAV
>A0A248K973|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori serovar 66:z41:- str. SA19983605|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQSQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDATEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWVLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A174RJ08|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MLYLVKSFFYFTTLICYSQELFNWPKKAKTFLHSRIKYFILYIPKLYLSTGETKYEKEKK
ISTNYVAAIIIFICAVVISLGLFLLYVQRSIDTNSQKAMTSNVAKQSDHALSILNIHYGF
LNSIADKMGDSSDILSDENMELLVSLAANTDFERTALIEADGTAYYDNGAIKNVAQRKYF
LEAMKGQATLSDPLDSSIDQETRVILCVPVRCNDRIIGALGGSYNVTALSQMLFNDIFDD
AGYSLIVTKEGEIIAYDGEPSYHKITYGDNFFDFYKDRTLLSKNSLVNVKKDFSAGNDGL
IKIRTDSNKKSDQYIAYTRLGMNNWMICYVIPVSDAQNSYSFIKSYEGIFMSVFCILVLL
LVFYIIHNNRIRNEELRHDAQTDGLTGVLNKRTTEALINEILEQRPHEKGTFIILDVDKF
KEVNDHYGHAVGDIVLSTLGQTLRNYFRENDIIGRIGGDEFVIYMCKTERQKWIFSFPKA
G
>A0A379J5S5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQPSIVARRPISLAQLRQQLNLQLQTSLEAERILGLFF
REVQRLVPLDALQYRHETSDLRLEYGQRGHHSVSYSLSHQGEHLGELVFRRNQRFSEEEQ
GNLESLLASLLYPMRNALLYRAATRSALRDPLTETGNRVAMDQTLGREIEMAKRHLHPLS
LLMLDIDHFKRINDSHGHATGDKVLKAVAASIKSQLRNVDMVFRFGGDEFLILLSNTSRD
AATMVGERLRQAAQAQDYWADTTRIELTVSLGCATLLVGESAESLLRRADSALYVAKREG
RNRLAMAG
>A0A125QI63|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVRDSLTGLYNHTHILQLLEDCSFRARRENKPLSFAMLDIDHFKRVNDSHGHPMGDRVIK
SLALFLKQRLRKTDYIGRYGGEEFAIVMPDTDLESACKVLDDIRRRFAEIHYPAQPQDLW
CTFSAGLVELCDGSDSLMMAAQADEALYRAKDAGRNRVQAARTSKQSAIFSPESTDSVIT
L
>A0A8B6XA18|diguanylate cyclase|EC 2.7.7.65|Derxia gummosa DSM 723|TrEMBL
MTLACSIPMTVLVVDDQTATRAALRAQLMQMGHRVLEAEGADDALRQFHRRRPDLVLLDV
EMPGHDGLWIAREMRSLEPDGWTPIIFLSARRHDIDLWQGIAAGGDDYLVKPASPMVLAA
KLRVMERLTLMRRRLVEMSETDPLTSLRNRRAFDLRLAQEIASARRERSPITLVLCDVDC
FKNYNDALGHQAGDRCLKAIGAMLNLACRRPRDVAARYGGEEFALILPGTPRDGAAAFAL
KLEQMVQLAGLPHPRSVVANTVTLSGGMVSCIPDETVNASRLIAAADEALYAAKAQGRDR
FVSIELERRPKPAPREVCIL
>A0A1C6AKR6|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MVKGLCRKFNALLRKEAVHENEPQRILFLLRIILLILGLYFLIIPLVFCIVGPKTEVWTG
YIFAAMSVAAFYATYRLKVHTSVLVCSGLQLAWVIVFVILYGWDCGIQHLMFEMLVLVYF
AVYNSLVYKISYTVVLFAVRFSLFLYCRVNISVFALTETATVVLQIINTIVTFVLMAVAC
SMFSSNVESAEKKLVLYNEQLKKQAGTDPLTGLWNRRQMMQYITEKHRKEPAMAFTIGMG
DIDFFKRINDHWGHDCGDAVLVWITQHMSRELGEHAKLCRWGGEEFIFFFPDMNGDEVCL
MLNTLRMKLDNDQFDWRGEWIPVTMTFGVEENDFKSNIDTLLKNVDAKLYMGKEQGRDRV
IY
>A0A5P9JT57|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MGFLCVAAVLREAQTPIWAWALLFAFCFVWPMAALGLSGRARSAALSERRFVLFDSLMGG
FWIATMAFNTLPSAILLSMLAMNNIATGGARFLLQGLLAQAAGGVLSVLLLGFGFSPHTS
QVQMYACLPMLILHPAVIGMVLYRLAYQLGENKRALRSMSRTDSLTGLFNRGYWNELLQL
EFSHCKATGGIASLALIDLDHFKQVNDRHGHVIGDELLRQVGYRIRRSLRTQDMPGRYGG
DEFCIVLPGARAKDAWEALERLREEIAGLDVPLAPKLSASLSIGIAEVDPRMEDAVAWLH
AADQALYEAKRLGRNRIALAKPLRAEDVAVS
>A0A8H9B8R6|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIDSLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKRKIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSNDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2C9EJ73|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MPLHVVRPKILGFISEEVSAWLVAVLVLVAGGILTGLLAWSTYSLNKQQVRQRFQLLAGE
RYSRIEERFQDQEQRLDGLRRFFVNSDLVTRQDFDGYAKPLLRRTQAYAWAPLVSRAQRP
GFEQSIRDQGLPGFSILQLNATGQMEPAGEHDDYAPVLYSQTQSPLGSPLGYDLLAQPLR
RATLERARELNGLAVSPPLQLVAVDQAYARGVLLAAPVRRAQDASGPQDRPYGYVLAIIS
LRQLVADGLPVPASDNLSVRILDLSTEGQHEVLYESNNPPISSSLTASRLLRLADRDYQV
DIRPSAAFLHANHSALGSLVILGGMLSLLLSALLYVLVSQRQRALALVEQRTEELRSSEQ
ALRGTHSQLRCVLNAATQVAIIATDLRGVISTFNAGAEQMLGYSSSEAVGHLTLESLHLP
EELESWAQSLTQRYGKAIPVSQAMLVEEGMAGGHEAREWTLVRRDGSHLQVNMLATPVLD
DQGLWIGHLAICIDITERKRVHEALAARDRLLQRLSAHVPGGIYQFKLDADGHTSFPYAS
DGLREIYEIEPQLLQQDAEAAFERIHPEDVERVRESIRVSAQQLSPWREEYRVCLPQRGV
RWMRGAASPESLRGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLQA
EMHRLERGGGVMAVIMLDIDHFKRINDQYGHGVGDQVLRGLCERIGRRLRRIDVFCRLGG
EEFMVLCPDTSGQQALILAQELWHGVRSSPIGPVESVTASFGIASWRAGEGADELLLRAD
SAVYAAKQAGRDRVLMEQP
>A0A8D9PQC1|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2P4EZC9|diguanylate cyclase|EC 2.7.7.65|Halopseudomonas oceani|TrEMBL
MPRLSVEQLSQEWSLLNQRFSEQSRRFVLSFCIRHAVDLTETFYTEMLADPGATLFLSHD
QVQGRLSQSMRRWLEGLFDSESEGALTRIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIALLQEDCELSDREHLDAARLMSDTVDLAMEIMSHAYSTSHDRNSRNEEAYRLFSVTQN
IASEKESQRAALFDWENQLMFDQAVGQPGEHLPRILASEFGLWFRHKGAHAFEGAPEARQ
IIHAMEQIDDVILPLFDSDSAERIARLRELRETVKSIHFNLDHLFEQNNALEAGRDVLTR
LLNRKFLPVVLNRQVSHARSHGTPFSVLALDIDHFKQINDGYGHEAGDRVLQQLASLLVN
SSRAGDYLFRLGGEEFLMLLVDTGLDGARRVAEKLRRGVEQEVFRLPQDRTISVTLSVGV
ACFNGHPDYQQLMRRADDALYQAKHSGRNRVVVVE
>A0A1S1VA23|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MNYIYTKPKILSIAFLIFLVSCFGRENLFLNILSGDVQSLAYVASMLALLSLFVSLYIKD
VKELESISFTDNLTETYNRYRFLEIAQDELDRHIRCETPLSFVMIDIDNFKKVNDDYGHN
AGDLALKELSKLISKNVRKSDIFARWGGEEFILMLPDSDSYSAYKISERLRLLVENYEFK
QVGHLTVSIGLSELTECHNLTGTIAQVDKALYRSKLEGRNRVTVSPKTLCGECDTCTYS
>A0A6J5CXX9|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia solisilvae|TrEMBL
MKPRIVTRYAQAHPVVAPRPSLERVLRRTYMRLAVSAVALAAVCIVFVAWTVLRAYANDN
LTLLARSIAYTVEAAVVFNDKPAAQDAIAQIAGNEDIADVRIIDTHGAIFANWQRTGDGP
LSRWVHRVADLALPGGVSVPVTHDGKVLARIRVRGRGHQFAIFLIGGIGGVLVCLIIILG
AGTLIARQMHRDIVEPLRALAEVAHAVRRDRAFSRRVEATPIAELHELGDDFNALLDEFE
VWQHSLREQNATLSHQANHDRLTGLPNRAHFESRLEQALRDARALGTAVGLLYIDSDRFK
EINDTLGHDAGDAVLVTIASRLRATLRKDDLVARLGGDEFVALLPGLDREENATRVAQAL
SESMLAPITLPGGREVTTSVSIGIALFPLHAHDVASLLRMADTAMYEAKRTGNRAWQIAR
ENSNSQ
>A0A6C8LTL6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lubbock|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1U7M2K0|diguanylate cyclase|EC 2.7.7.65|Tissierella creatinophila DSM 6911|TrEMBL
MEFFNLIKVNLFAFIIIFLIFINIKRDSRNILTDQKLFLTLIILTLSLLIIEIVKTFVDG
REGAFMIKTNLLFSTIDYILAPVTSMIWALYADYKIHEDRARIEKRLTTFLVPIIISIWL
TMINLTRGIFHGILFYVDKTNIYNRGPYFQVIMIISYGYLFYTFMQIIKYKNDISSKNYY
SLIAFIIPPFIGGIIQTLFYGVKLTSVSLALSIFIIFINIQNNKLYIDFLTGLYNRRKLN
IYLEDIITRNKDKLIGGIMIDLDDFKSINDRFGHSEGDKALVYVATILKNNFRKEDFIAR
YAGDEFLIILKVNKVTEIKGIVERLKTNIEKFNSENITPYKLSFSIGYDVFRGDSPITSE
WFVERIDNLMYQQKESKKLSFEV
>A0A1U7M4W7|diguanylate cyclase|EC 2.7.7.65|Tissierella creatinophila DSM 6911|TrEMBL
MEMQGRIIRFLCILTILIFVFMNITNEFDPLREGIILDGAWKIALEDSISFKEKEFNDSN
WKEEEFIYKNVLIKKEVEKLDKTIWVRKNVVIPQELLSQDLMLYIPRLPNYHKVYFNGFL
IGKTISSPEDLFNDWNRKYGYFIPKNLIQYGKENTISIKTYSSYEYGPSKSLTIERAKDV
LKRINIYSSSYTYMYLTNMIILLGMSAYFYFIFTRMKKKKYSYFATLCFVTAIYYIDYFV
STLPIPYIVFKKIVLSCMFFVPILGVLFLREFLSLPIYKAQKINIYIRIMIIALGVILFK
DTISYYKFRRYYMIIFTLDYMYIFFMVLWDYFKNHTKKKWIYPLLLIILLMCGHDICNAL
RGIFPPLGFHLNIYALMIFIGIVALDLAKEYIDIFTKAGKDGLTGLFTQSYFKNELIEIV
KDKDIIKKPFSLMMLDIDKFKTFNDNYGHLIGDEVLKIVSRIIKETSPENAIVTRYGGEE
FGIILKGYDEKESLVLGEKIRKNIEEFRLKIDENSSTNTTISIGITTFDPKRILIHSEML
IEEADKALYYSKENGRNKVTHHREMRYKR
>M5FLB8|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp. STM 4661|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTATNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLDAGADDFLTKPVNDLQLMTRVKSLV
RLKTLTDELRLRASTTRNIGIEELLSRNFASEDTMPKVLLIDERKSSFERIQKMLRGSAD
LDIATDPHAGFFQAAETPYECVMISTAFADFDPLRLCSQLRSLDRTRFLPIILLAEQGEE
GRLVRGLELGINDYLMRPIDQQELTARLRTQIRRKRYNDQLRASVTQTIEMAVTDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKTINDAHGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTEGAVAEKVAERIRAEIAQMPFAVGSEGKTIEVTVSVGV
SSVLKGVDTVAGLMKRADLALYEAKSGGRNRVVAKAA
>A0A136WGV4|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MDNVNVLLEHLSVFKNLYEMVRIVDPINKRVIIDNKGYIPTVGNCFDLWKSKSYCSNCIS
MRAYNEENTFVKIEYNKEKIYMVIASPFNIGTNKYILELLKDITDCSIIENYVNKTVDEV
QKIIEEMNNKIIKDELTGIYNKRYINERLPIDIIKNSNEKNSFSILMTDIDHFKFVNDNY
GHLAGDKILVDFAYILSKSIREGIDWVARYGGEEFIIVLNYADNSIAYEIAEKIRRSIEN
NIFTYEGQEIKITASFGICTMPNDDMDWKANDMILLAD
>A0A136WDW8|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MKRKHFVFILYMAVIAVFLFVCAYAIGFLHNDTSEAQYKKTANINEGWRLKDEDTTDPIG
NLPKVVSAAKAGGTLFRQLPENLERGSILAFENRFQDVRVNIDGKERYSYNGLLPNVNRR
LNTNFFCMIHLDAEDSGKIIEVTFRSPSNQKSIALPIFTIGTEMEIFLEFFRLDIVTLVF
SGIMIFFSVLFLAIFIRERCSKGENCAILAHSAILMALSGIWSIANSSAVHLCAYNDMLL
SYLSFHSFMLLPVVIPIFYCDILEVHKKFLYRLSCGASLNFIMQNVFFFSGKFQYIEMMP
ISFIVFLFTIFALAGISIREFVKKDSTYTGGFLIATAVFGGFFTLDVFRFFYYRPSDNAM
FFRYGVLAFIVIVFWIFAKRMLCYVEVEVENRVYKELALRDVLTHLPNRTALEKRIKGLE
EDGKVCNFFTVILMDVNGLKPVNDKSGHGAGDRLLCEAARSIKEAFPEEMDAWYRLGGDE
FVVLMTETELDNEQCQQRLLMATEKWKNEDYGPISISCGSKTEKNFKITREAVGQVMHEA
DQMMYRHKILYYQKKMNKKTV
>A0A635JD20|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A8H9PJY7|diguanylate cyclase|EC 2.7.7.65|Kluyvera intermedia|TrEMBL
MFPKMMNDNNFYTSESGKERRSTLHDDDPHAMGLQFAQRERLPRTAGLACLFMPLAGVLV
SQPVAGGWWILLALWSFVWPHLAWQLAARSSDPHASETHNLKADAVLSGVWIALIGVNML
PSIALAMMVFITTMGAGGPRLCLAGVVLMAVSCLVTLQLTGITIAPDSSPLIICLTVPVL
LLYPLLFSWVSFRNAARLEEHKRRLQVMSIRDGMTGVYNRRHWESLLRDEFDNCRRHQRV
ATLLLIDVDHFKTINDTWGHDVGDEAIIAITRHLQLTLRGSDLIGRFGGDEFAVIMCGTP
PENAIAAMERVHDRLTGFRLPSAPQLALQISVGVAPLTDEMTHYREWLKSADLALYKAKK
AGRNRTEVAA
>A0A210PC80|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MTWHVWQVSPFITSIFFILGVFTLYQVLYDWLKSISHYKNLRMTDDQLKDVFGILYMLIF
IFSMQATIVGKSISWEFMNFQIMAIIFCAYFLNIRIPYRYFIPIILVYMIFNSSIGYWES
WCHAWTLIMSYESFNHIRRMQEEDHRFARYMMVGVVYGGLMWFFVMVKFNLTLATFYEEW
FYLVIFEILLYSYVNMILRDSKLKMHLLEFANHDALTKAENYAAYMTEIQYEFEVCQRNK
LHLSMMMFDIDHFKKVNDTYGHLAGDKVLQHVADVAQTVINANDPKVKFYRTGGEEFNVV
FPGYDMDSTKDIVNEIFMALNHLEIDINGKKIYITISMGVSTVTAKDVQPNDLYSRVDDN
LYHSKNNGRMQITAF
>A0A4D6P5M6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>I6EAW7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNHDYLLSTAHNAIDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>I6EAW8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGT
PLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEA
SENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIA
KRRGRNRVELWKASL
>A0A8H9VHR2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQHQRVLVTTPHPLMRLVCLGLVTFIFTLFSLELTRFGALLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWSSINPTYTAINVVEAVVGALLLRKLLPWYNPLQN
LNDWIRLAIGSALIPPLVGGVLVHLLIPSPEPLRNFLVWVLSEAVGALALVPLGLLFKPH
YLLRHRDPKLLLETLVTMAVTLVLSWAAIVWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAHNPEALTTQHTSAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIDGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRSGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRESLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGEKGPLMENIHSGDMSRSDIEQDVVLNCRTGGVYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLVHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNNGRGVV
TVYEPQQERAHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSEFFRAYAAPVAKKGLGVALPLSAAGLASTTLI
DELLDLLDKGPLPGRLLHLVIAIDVVASPDPNVQTGLQKLRHAGCRVVLSQAGRNMELFS
HLGANVADYLMLDAEVVTNVHGNLMDEMMVTIIQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGVDFIFGDTIGEPQPLDLLLNTSYFAIN
>A0A7V7JHY5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRSRPFWQLAVDT
KRTLPINGVSDAFVEKTTLLNRDDELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTETATKTADIIPRYYHLVTQPWFTQQTERNNRARAVLWFITSPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRMLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIENNTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
GQCQAQSLPFSVVQIDLDYFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKELLVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWNDQDKK
>A0A8H9S8B6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MMSDENFYNKERIGEEWLQNLSQDDAHRTGIRFARRVRLGRIVGLAAMFFPVAGVLVTHF
LPGGWWLLLVSWVFIWPHLAWQFTCRSSQPYQCEIFNLKIDAIFAGIWIGLMGVNALPSA
ALVMMMGMNMMGSGGCRLFLAGIAITTLSAVVTLKLTGNVVVLSSGALEWWLTLPVLMIY
PILFAWVSHQTAIRLAENKRRLELMSTRDGMTGVYNRRHWETLLRMEYEKCRRDHCQTTI
LLIDIDHFKSINDTWGHDVGDEAIIAITRQLQMTLRAGDYIGRFGGDEFAIIMSGTPAES
AIAAMSRVHERLKKLSLPCAPNERLRISVGVAPWGTQFAHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A7Z0VL20|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MPRVLLVELSATIRHIEKNLLIKAGYEVEADLDFNSALRRFVPGSYDGGTFEAVVLGWPG
DAVHGADELYTLLEKNTYTSLPLVTLAHESDADLIRRVERRDNSAFLLWEDYQKSTELIA
KLLIDANQRKRTEATANSIVQPIRVLFVDDSRTVRVKYQRLLMANGYEAETAATVGEGYE
KALDSRFDIAIIDYFMPDATGDVLCQRLRDNATTTGITTAIITGTYLDKAIKQSLEAGAV
ECMFKNESDDLFLTRIDAMSRHIRAHKSIEKERERLGGILRSVGEGVYGVNSEGYISFVN
PACRRILGYAPDERLIGKSALELFHYTDEEGNPIDETKCFLQHTYADGTPLNARETLFWH
KSGDSIPVECTVYPLTIKGKREGSVVAFRDISERKLLEEELRWQASHDALTKLYNRRYFE
EQLTQEAGRLKRSKETSALLYIDLDRFKYINDTAGHVAGDRLLVEIAQQLKQRLRSTDLL
ARLGGDEFAVILRNVCKESIHQVADDYREMLDSHMFIYNGKQYKVNGSIGIALIDKDSES
ASEILANADIACHIAKGEGRNRTHLFIPESDSKKAMDLDLGWSSRLHNALVQDHLVLHYQ
PIIPVEFISPELMLETEGPIYQRLLSIVPQEQQISELLLRLDDPMWGIVFPGAFLPTAER
FNMMDKIDYWVVNAAVKKLALLQQTGYTGMFTINLSGQTITNKQLIEEIETLVVNSSVDS
GKVIFEITETSAVSNLVSANELITRLSALGCRFALDDFGSGFSSFSHLKNLPVDFIKIDG
LFVRGVATDPSDRAIVHSINDIAHSLGKKTIAEYVEDAAILRFLYESGIDYVQGHFLSPP
MDISHFVPQAVQHIPGNKKQLIGKK
>A0A157JL91|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MALHSKKLSFTRPIMLSFAGIICSFVVIAVAVTLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRSAMYFSRNDRLNETLNVNPTQGLQMVMHLQNLMPTVSSISLADTQGH
YLRAPEVLPTEKSKTFDPRTRPWFVAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPE
GRLKGTIAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRSVLMHIINAIKTGDVSEAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDSDIAELLNAQQPFAMALVDIDNFKSINDTLGHLTGDIVLRNVAREGIQI
MQPHHVSLYRYGGEEFAVIFQAEQMTSALSLLEAWRTAVEKRVWREENLRVTFSGGLGEW
HFEPLDQFVGSVDNALYSAKQQGKNRINRTSIS
>A0A0X4DNA9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLF
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAINMAMTDSLTGIPNRRGFYR
AGDKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTGSYLHALSASLDHYNDTSGKPYNINYSFGELINNADQYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A6S5KAC4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTYFVKRSFLQWLHNRSNPGLIVNICFLVVLIFSTLLTWREVVVLEGAYVSSQRNHL
ETVASALDRQLQFSVDKLLFFRKSMGEALQTPLGFDVLQMAVARFKTVRNTPSWQLIVDK
DRTLPVNGVSDEFVSKTTLLNRDDEHISHEISAALEVGYLLRLASSSTQKEERAMYISRA
GLWVATNTPVNDDEIISRYYHFVTRPWFTQQSGRANRARAVRWFFSSTTSTAPADAPTIT
ASVPVYFNNYWYGVVALDFSVATMKRLLKDAVADHTEGEYQLYDTRLNLIASSEASASKI
NLFDDVERAQIASAIAGDTEGGLRLGSRFVSWERLDHFNGVVLRVHTLDEGVRGDFGSIS
IVLALLWALFTAMLLISWLVIRRMVRNMYTLQNSLQWQAWHDPLTRLNNRGALFERAKQL
AETCQQQSLPFSVIQIDLDHFKNINDLFGHQAGDKVLSHAAGLIATGLRTSDVAGRVGGE
EFCVVLPGIALPEASAVAERIRSRIDSKEILVKKNTTIRISASFGVSCAHEKGNYNFEQL
QSIADTRLYQAKQYGRNRVVWCDRDKE
>W6R067|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MSQPAKPPSIIDLYPEETREAAELLKQAVPLMMRHNIPPNPVHYALWYTYSRGSEPELNR
RLDKVVEDFDAFPLKTASRLFRDYIIRGELEEARAGQQQVIELVDDIEGDVSRSVLGSQY
YQQSLSQGLSALQDPIVDDLPSVLSDLQESTQLIQDQQEKFLYRLRAAQQEITHLRSQLE
RAHLAATLDSLTRVFNRHAFTRLLERALNESYQGLALVILDIDHFKQFNDQYGHPLGDRV
LQHVGQLLRDLLPPEAFAARYGGEEFCVVLRNCANLNGVLDFAEQLRHKLQSLRVKVRRT
DQILDSITASFGCAMAEAGDTFESLLTRADDALYQAKRAGRNQVHPITSETMLSA
>A0A8I1Z6L8|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPAGLVDGRLQRQLACFGFEVTVVSQAAKLAKALQRQAPAAVVAFADFTHNDPILQLAPA
ISSCCPLVVTSPRRDFPARLEAVRMGASGFLDWPLQVNQLVDLLSFGDIGERRDPLRVLI
VEDMASLAGLYSRVLGAHGVEATSETNPERVPELIEHLNPDLILMDMYMPQCNGIELAKV
IRQQRLLDGIPIVFLSVEKRQTVQLDALTLGIDGFLTKPVAPEELVVTVVNRARRYRKLR
SYIANDSLTGLLNHSHLHGQLDSAILRARRVGQPLSLAMLDLDYFKQVNDNYGHQVGDEV
LLTLARFLKERLRRTDLVGRYGGEEFAIVLSGTPADKAHGMLETLRQDFGLLEQQVGERT
FRQTFSAGISSLASAATSTELVQQADEMLYRAKAAGRNRVVCHEG
>A0A1V4W2M4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin117|TrEMBL
MVDFYLFIILFVLFMYVLVANDITILYKVYLAFHYFLGMWPFCNFLINVIPDQQLQWIFL
SAAFVSLCFLGYGWHVFSLVLTGKISNARKLHLCLWAAPAVLCSLLVITNPWHYLFARPS
ADGWMTRTYGPFFWLFVFFIIIYFIVGGALMVNELATVSEKNKKKQLSLCIWGVVFFLAL
SIADVLLNTFVLPKSVIVPGLTSSGIVILTICFVVAIQKYDLFRIVNIARREVIDSMATG
MVIIDQNEVVLDINKSAGKLLSLQPGQVFDIKKFYPHSETESAGLFLEDYNQKRLKKLKT
EIVIRREQPRHITMHIAPVVDHKKNLLGRSITFNNVTELRKLIEKINEKNATLERQNDEL
LRFQTELYEANKKLEQMAITDALTGCYNKRYILNQLEYEIVAAHRYNIPFSLMLMDLDRF
KLLNDTHGHLTGDDVLRDVVEIIKKALRKSDIMARFGGDEFIIYIPQVDNEGAVVLANRI
KSMVENQIVKTMIGDLTVTLSIGLISVVNAESINIREDFLKELLARADSALYEAKLKGRN
RIVAESFNGASRCPANMESG
>A0A6N2Z0E3|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MMNNKNTAKKMSINENAILEKYLNTLATPISKHKPDKKLSFIWANDAFYKMTGHEKKDFK
MIWQDLKTYYKPYTDDFIILENQLAKLQEHRDLHQECIIRIPFRHDEIKWIKLSISLSFE
VITIAYNDISNLINTQNTLISTKNVYIDNFQWMMAENAGNVYISDIETYELLYLNKVACE
TLGTRAEQAIGKKCYEIIQGRSSPCPFCTNKYLKKDQTYEWEFYNPLLKRNFIIKDRMLN
WHGHSARIELSHDTYSTEYKLAKKDQEREAILKTISAAMVRVDARDYSSILWCNDIFLKM
IGYTKEQFKSERYELKSYMHPEDLKRAKQIVHKLRNSKESVVFEGRVYTRNKEERIWTLT
LCYVDERDSWDGIPCFYSMGLDITDERQKIKTLQHKAEKDALTGIYNRSETENQIKNFII
EHHDSKGALFMIDTDNFKQINDTLGHIAGDMVLGEMATAMKKKVRDSDVVGRIGGDEFII
FMKNITSHLDAEKKAEELQKTFAHLFDKEKSKIQVTSSIGIALYPKDGHNFLELYANADK
ALYQAKIQGKNTYIVYNEKSCNQQSITAYSSLGATIDSQQSYSETSVSLADYAFRILFQN
KDLKTAINLILEITGKRYDVSRAYIFETMTDKEHCSNTYEWCNEGITAVKEQLQNISYHD
MDEYERVFDENSIFYCHDVTSLSKKQRQLFEAQGIHSTLQCAYYEQEMIAGFVGFDECTG
KRIWTKEELRMLTLISQIISIFLKHKGLSDQVSKL
>W6QPV2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MPANRHTTLAYLVSLPGLLLVCSLLLASQITLASTRLGDSSAAQDLYGLVDFLADPQSAL
SLDDVRAVDAPFQPSLNRRDLSFGYVSGVIWLRLALQSDAQQTRVWRLELNYASLDEVRL
YDIGADGVRESRSGDTVPYAQRSVGHRNPVFEIALQPGEQRTLYLRVDSRGSMTLSGALM
SSRDFEQHSQNGYLAHAIYFGVLIALGLYNLLLFLALRERPFLNYVLFMFAFALSVLSLN
GLGAQYLWSEAAPWSNRILPVSLTTAALLSVVFARSFLDTRQWLPRWDKGLLMLSIAIGA
AVLASVLLPLQRALQLMSLTGLIATLTLLVTSFVCIGYRVPGARLFALAWLMLLTGAVLL
ALRNFALIPSNFITLYAMQIGSGLEMILLSFALAARLIELKRQREAALQLNEQILAKRVT
ERTQALEQANQRLSELALQDPLTGLPNRTALQQHLEQALARSQRRNELLAVMLIDLDGFK
PINDQHGHGYGDLALAEVAQRLRQYVRDTDLPARLGGDEFVVICESVQSAEDAHDLAKRL
LEGLDTPMYLEDRTVRVGASIGIALSRGADDASMLIRLADAAMYRAKAEGRNRVQLATQY
L
>A0A517P3H5|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium K23_9|TrEMBL
MLLSSSMLSLAVIGSEQVWMTASMRVALWAAASDSSAAPLSISWPLLIISAIGILVFTFG
LGYVLGKRTSKQVRHAVPSDTAAELQRAIEPAERQRMLELLREIGTWSNEYSGQLSEYQN
ELGELSRSVQQNSGSDPKIGDTSERITMLLQQFMQNSGQLQQRLDAAEFQLEQKTRQIEC
YLNEARTDSLTGLFNRRAFDQRLEELFRNYRRGGRSFVVALIDIDHFKMVNDTHGHQTGD
AALQAISNLLKQCLSETLMVSRFGGEEFAVIMDGPLLSAARQLDTIRRSLCQRGLELEKM
KLTTSMSVGLSEPMDDASASSVVRRADEALYAAKNFGRNRVYYHDGREPTLVGSPETARN
L
>A0A564V2Q7|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDI
>A0A564V2M8|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQS
EDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VSRENISDAMTGLYNRKILTPELEQRLQKLVQAGSSVMFIAIDMDKLKQINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A6N3CVH1|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MKTLKTILVLLIMSMLINIIPIKAASRTVKVAYPIQSGLTEIDEDGLYSGYTYEYLKEIS
RFTNWNLEFVRLEGTVNEQLSSAMEKVKTGEIDLMGGMLYIDTLINDYDYSATNYGMGNM
AIYVNSNNAEINDTSIYSLKNLNVGVVSTKKETNVNLKDFGDINGININQIFFDNTPDLL
TSLERNEIDAMVLSDLSIEEGNYRVVARFSPRPFYFVMTKGNQELMSELNEAMTQLNKEQ
PNYMSNLHERYFSLANRNFILTETEKGFVANNSKIDVLILGGKAPIQYYDEKKGKVVGIT
VDVLNYIGKLSGLKFNYIYANDIDEYNKQIETKKPMIIGGVYNSNPEKYITTKAYLDSAM
TLVTNKNINANELDGKQAAMIYDSEVDSAAVGDSSNKVNYYGTQLECIKAVENGTADYTY
INNHVALFYNSNYDFKNINIIPQGNLRNQGSYFAINTGVADELLDIINKGIDVVSYSKIE
EIIFTNASTSENDVTFFDYVENNQLQVATFTLMAVAIIVLFFLIWRNYINKRNNEKILSE
YKRYQQISEFSHDCFVEYNIATDTLVLMGGGAKLLSKETIIKDFLKRPISNKDTLEMSLR
NLTECESEEFVKFIDGKKRWLKINLRPIFDLNNKPTHIIGKVIDIHSEKEEQLLWRELAQ
KDSLTKIYNSAACREKAEEFLQNNTAAQVALIIIDIDNFKYINDTYGHLCGDIVLQKIAQ
ALLEVSHPLDIFGRVGGDEFLTLIKYPKSIEKVAEYCQNMIKSTSKVEYQGTHIIISISV
GAVVSSVSLSYDELYRLADDALYRVKNNGRNNYCIIDYDKENTSS
>A0A1V5E112|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MDKTLRILMLEDNPCDAELVQMELKSAGFSFTEKVVMTEKDFLLALRDFFPDLILSEYNL
PQYTGALALAEAKRLCPDVPFILVTGAVGDEKASEILTGGAADYVMKKDLNRLVPAVQRA
LAEAEAGQEGGKAGGNFRRDRGRPERGTGGKTERPQAEGTGCRKTEEALSRSRRIAERLA
GEMAVIAEIGRLISSTLDIDEVYGRFVTETRKLIPFDRLNVYLNDPSRNAVHIAYVFGPD
IPGRRPGDSFPLAGSTNEILVHRRAGLILGAGSVERIVRRHPHRFPSFRAGMRSFMSVPL
ISRNDIIGALHFRAKKPDAYGDQDLRLAERVGAQIAGAIANARLFSNLKESERSLRESEM
RFRAIFEQAAVGVAEIDIGTGRYLAVNRRLCELLGRTEGEMLATTFQAITHPDDRHVHEE
KTAQLDAGKIGNFTLEKRYLRKDGKVIWVNLTISSLWKPGEASGRNLIIVEDISERKRLD
SEMREMFLRDQLTELYNRRGFINLAEHQLKSAARTKRWLQLTFADVDGLKWINDNLGHPE
GDRILIDAANILRRTFRESDIIARLGGDEFAILAVNTNGYDPEAFSARLQGSIDEYYAGK
PGRCRLAMSWGTAVYDPESPVSLDGLMSAADGLMYLQKRTKANRR
>A0A1V5E8K3|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MRDKIKRAGTGVSEKQGVTLAGNRMEMDRLIHELKQAEEKYRNIIENIGVGVAMIAPDMR
ILALNRQMREWYPAINPSMNPLCYEAFNDPPARDICSYCPTIRTLRDGRVHEAVTETPTK
EGVKNFRIIATPVTDSEGRVVAAIEMVEEITERRQAAEALRASEQRHRSYIELTGQLGWT
TNAVGELVEDLPKWRAFTGQSEEEIKGAGWVNALHPDDRERALEVWNRAVAAKSAYEVEY
RVRRRDGVYRHWLARGVPLFREDGSIREWVGTSIDITDMKRAGEELKKSESMYRTIFETT
PGATMIIEEDTTISMVNREFATQTGYEAGEIEGKKSWTEFILKEDLDRVMGYHRLRRLDP
AAAPRNYEFRYTDRKGRVRDVYATVAMMPGTKKTVLSLLDITDRKRNEETLRTMAEELKS
KTNALEEMNAALRVLLKQREEDKVDLEKRILASVKELVIPHLRELKKCMSGQKELIRLQI
LESNLQGIISPFAQKLSLQFLNLTQKEIQIANLIKEGKTTKEIARFMDLSKFAIDTHRAH
LRSKLGLTNKKANLRTYLSSLIE
>A0A5K1IAW1|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MWKDFITSGGRSTLEDPDFLRLSIMNVMAGAGCVAFLLFLVLDSTGSFGWSTLRIATDLL
GIALTLGVIVGLRAGAPLGVMAKLSHLALFVLLLLLAVARGESVLAVTIPLIYPAPAYLL
LDSVYRASIGTALMVLCLYAVILTNTGGFFEDMVAVLDGALSITLAMAFQAAVMALYLRS
RQQSIAWLKSLKDTLAFQSAHDPLTGLQNRYTFDEVISREMRRRSDDRLFAFLMLDIDSF
KAYNDTFGHPEGDELLQRLAKAVQGLFNRAEDHVFRLGGEEFGIVFRPRDRSEAALMADR
LLEVIESMEVPSPGGPHRHITASAGLLCRAPGPGPDSETIYRLADQAMYRAKETGRARWV
EANDEKRKNDGTH
>A0A1Y0N5N8|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MASHTDFELLFDSAPISLWLEDYSLLKNLFDQWRSEGVTELETHLFADPRRVQACADCYR
VLRVNRQTLSVFAAQSQDELINRLGEVLRGDTYTRMLPELLAFWQGQLQYSGVTVNYALD
GRRMDVRISIRILEGHEDTWSRAMVAIEDITEHTLAQGLLESSERHARNLFEFSPVSLWV
EDFSGVKTLMDEVRVSGISDFKTFLSVHQEFVHRCMERIRVLDVNQHTLQMFSAGSRHDL
LSQLERVFRDEMQHSFAEQLLDLWNGKTVQTREVINYSLNGELINIHMQFSVLPGYEHDW
SLVLVSLVDITARKKAEAYLEYLGKHDALTQLRNRAFFVEELNRISRKGPWPLSVMAMDL
NGLKHVNDNHGHAAGDAMLRRTGEVLSKATAGQALCVARTGGDEFVILMAGHDERAAQAL
KERIDSMLEMNNQFYPGQKISLSIGVASCQSAAEVEETAQLADQRMYAAKRRFYEEAKLE
RRSN
>A0A8B3SY96|diguanylate cyclase|EC 2.7.7.65|Pantoea sp|TrEMBL
MTIEILSPQNSTPNRWLSALLLGCVVFVLTLFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIIIGPALSNIKFALLNLIQAGVGGMLLRALLDRRAPLDS
LHDWARMVLSVGIVTPVLGGLLALWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRTGFSNLRLAEALLTLLLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFISILLAFDLVTVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPHGIWLQVNRSLCQILGYPAEELKRLTFQQITHPDDLSL
DLQHANRLLAGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDGNQEPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWIHL
LHPADREYAALTVQQAIELRSAFHMEYRVVDDQGHRWVRTQANRLLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGWSQEQAAGQ
PLSELLHITQGRNGPEVESLLLCQLPPEKVTPGLAEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHPLRSSDFLARLGGDEFALLMPDCDI
AQAHDVVQRIVAAVNDYRFQWLGRLYQVGASAGVTQISAENCQSSDVLSQADIACYNAKR
SGRGRLVVYEQHRLPLSGNHQGMDAAMIDALQIELPAWAVAPPKTPQAAFIWLLEVQLLT
ADGLLLDETLLRNNLPDETLRRRLDNNILEAFFRHDVQRLNNKGIPVILPLNAQVLSDAA
FVQQLCQRFVAAGLSSSGCGFAFPAASVLSQGDQLYAALLQLRQCGCRIVLQHFGRNLDA
FNLLSDEVVDYLVLAPELVANVHNNLMDEMLLIIIQGQATQRNISVLAGPVSVPALLSTL
ANLDVNGVWGSAVAERQPLRSLAEDHIFAIR
>A0A7L7IKL4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00175|TrEMBL
MNKDFTSAPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLATLGKQGQFAVAEVLNIHEKRFAWWSWNPEDNTDTLGALVS
RWLFPNPVAQPIMHNGNKIGEIRLTARDSLISHFIWMSFAVLTGCILFASLVALTITRSL
HHGMVTAMQNITDVVHDVRTNRNFSRRVKEGRIEEFHHFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKMNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGENRHQSYRLGGDEFAMILYGVHSEPDVQHICSALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYQVKNQRSKTIS
>A0A7Y9WBN5|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia bryophila|TrEMBL
MDTPKPHRNAAAQDLAEDDANAQAQALEAEDAPNLAVDDALARILGNPPAAECPIMVLLV
DDQAIIAEAIRLALAGESSVDFHYCASPEEAVRCADETRATVILQDLVMPGTDGLTLVRQ
YRQNPATRDIPIIVLSTKEEPLVKSAAFAAGANDYLVKLPDRIELIARIRYHSRSYLNLL
QRDEAYQALRQSQQQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWRRAMRDKTGLG
FLMIDVDNFKAYNDTYGHVAGDEVLKRVAQTVEACLGRSPDLAARFGGEEFAVVLPGTSS
GGLRLLAEKIRIAIEGLMIPHAGSASGVVTISIGAATLVPSAAEPVTKLIEAADVGLYRA
KRDGKNQVAVSD
>A0A5H7D1C3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tudu|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKGNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7W3G1H2|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQASMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A7L6UB97|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C21|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGMRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADNPLHSEFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDIGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7W4KJN8|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5H7CW95|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tudu|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMVLKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A645GTV6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MISAAQKLKESFPNELVGRIGGDEFIVLVEDVTDIEKVKQQAENIVSLLKIHSDNGDILV
TCSVGITLFTYGDDFDQVLDQADKAMYHAKQKGRNQVSFYLEDSLR
>A0A7W3BRX7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00271|TrEMBL
MSKQFQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSHFGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGDSLNYTYTTINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLALGSAVIPPLLGGALMWLLLPEGTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STILMVSLMLAANPSLLYTPKANVMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNNDL
EQLGMLVRGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPPHIKPSWQVWYECVV
PEDREHAENVIRDSLAARIPFKLEFRIAVRDGVRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDADMNVTFMNPVAEKMSGWQQDDAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGGSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHDTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
SGRIINAINEYQFRWEDRLHRIGASAGITLIDEKNYIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQTHVSRELLSFDEQKHIIAHNPMLMIARGVASPRIPETFSFWLLSLRLGTED
GDVIEEHILRTGLVDPALNHALDRRVFNEFFQHAAAAIASKGLSIALPLSAAGLLSTELV
DEMLAQLQRSSLPPRLLHLTIPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVE
NLKFHTVDYLLLDSEISASVHGNLMDEMWVSIIQGHAQRLDIKTIAGPVQMPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A2T7B1R3|diguanylate cyclase|EC 2.7.7.65|Cronobacter turicensis|TrEMBL
MPDKILISRWRTKNPIRVVNFCFCVVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDAVMAGFNADRHKREWTLPTGRDLAPEIQ
GVSDAFIAQSTLLERDEALLYNELNATLALGHMLSIADARSERPEVRTFYVSRAGFYLTN
LPFFGHGSIPELYYQQVSSRWFLDQSLRRNPGRGVRWLHGRDLSMPSGQRVTASIPLDDN
GRWFGVLAMDFPIPAMRDFLKNALNDDDSGGEILLFDRQLSPITTTSSRNDTALHFTAQD
KAALARQMELANEGDARMDTRFIAWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARLAAKTCDAQ
QAPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAEDIAGRVGGEEFCIILP
GTPSEGARHVAERIRQRINSQEILVRPDTTIRISVSVGVSEALRDGDYDFEHLQSIADRR
LYLAKQRGRNQVCDEG
>A0A0W0U5T8|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MLSANMIPRHELQQIIIQLEQALSEHLQWYSTLLRALVCHLPIDNNNLQADGHHKCIFGQ
WLCTSAPKELNDYPGFLTIDEAHKKIHLLALQLVKETATGNISPVSYDLFSSALAYLQLE
ITALKGELESLLYNRDALTGAISQLGILPILREQQELAKRQDQNCCIAMVDLDHFSEINE
QHGRYIGDKVLAAVAHYLIDNLRPYDRVFRYGGEEFLLCIPFTGLAPSQKVVERLRRGLA
TITIDAGQQETIRITVSTGLALLDPHMPIEQCIDHSMQAMSTAKAAGRNCVKIWETSNE
>A0A5M9IEV1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MIKASLRSHLTLWFAGLSLLILLSVGFYVGHIATEQMKQASANTLLSTARSTAALLAVQL
RERQLEVSLLSKAPLFRRGDLDAPDILALMELRTQSRAEYAWMGVADADGRVRQAVNGLL
VNQSVQQRPWFQAGLRGEYTGDPHEAVLLAKLLPGAANGEPLRFIDFAAPIHNARGETIG
VLGAHAHWRWVTQIVASAVTQKDALPDIEALIVDFDGKVLYPEALAGEQMPKDKLVTPTG
WFTDNGYVTASVAVPSPSNARVSWYIMVRQPLDVALQPARSLLYKLLVLGLLAAIIFIVA
AYYLASSLSRPIERLAKSAKQVQDHQPGAVFPQEHPVLEIAQLGQSLTGMTQSLLAKERE
LQDANASLEATVAQRTADLTQANADLLKLATHDALTGVFNRRRFDEKLAENSLLFQRTGR
TFALLLIDADYFKRVNDTYGHAVGDDVLCQLAALIENTTRATDFVARYGGEEFAVLLPEV
EEPDSPDVVAEKIRAAVAAAKFPTVSQVTVSIGVGVAEPSDRDSLALLKRADMRLYEAKG
AGRNRVA
>A0A5M9IIP0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MPLQAVRPKILGFISEQASAWLVALVVLLAGFALTAIVAWAASDLYQQQVRQRFQLLVNE
RYTRLQERFEDQEQRLNSLRRFFVNSDVVSREEFDGFAQPLLLRARAYAWAPRVFREQRS
QFEQEVSRLRGVPFVIRELNSAGELAPAPERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RSTLERAQKSGKLAVSQPMQLVGVEPAYATGVLLVAPVSHLPTSEPSPNEPYGYVMAVIS
MRQLVADGLPKAERDNLVMQIVDTSDLQKRVLFESGNTVANSDLAGARRLTLGDHVYALS
LRPSKVFEQANYSSLSTILTMGSLLSLLLSALLYVLVSQRQRALKLVEQRTVQLRLREQE
LRGAHGQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGYEAEQVVGKLTLESLHLAL
ELEARSASLSVTLGKRIPASQAMLVESPDNLHEAREWTLVRQDGSQLIVNMLATVLLDDH
GLWIGHLAIYLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPQDNWRFIYASDG
MRDIYEIEVSALQRDATKVFDRIHPLDAERVRASIRLSALQLSHWREEYRVQLPQRGLRW
IRGEATPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLRAEM
ARLNRTSGALSVIMLDIDHFKRINDQHGHAVGDGVLQELCRRISQRLRRTDVFCRLGGEE
FMVLCPNTDGEQAYGLAMELWQSLRNLPMEPVGIVTASFGVASWRVDEGIDGLLLRADSA
VYVAKQAGRDRVEAERARA
>A0A0I1BDR0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWERELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLQLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A5F1EWY9|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGGLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRAYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDREHTEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSSIG
SVLVIQDVTEARKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVHSTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFMWEGRLHRVGASAGMTLINDSNHQAAEVMSQADIACYASKNGGRGQV
TVYEPQQATAHNERTVMSLDEQWRMTKENPLMMIAHGIASPRITETRNLWLISLKLWSSK
GELIDEQAFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSVAGLGSVTLV
DELLEQLEQSSLPPRLFHLVIPAEAIFDHGLAVQKLRLAGCRIVLSQVGRDLQIFNMLKA
NMTDYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVLDTLSDIGVD
LIYGDVITEGQPLDLLVNSSYFAIN
>A0A0D0QZI0|diguanylate cyclase|EC 2.7.7.65|Staphylococcus gallinarum|TrEMBL
MFEAIIYNISVIVAGIYLFHRLQYSENRNMVFSKEYVTVLMTIVALLLSAYPVTIFNEYS
LYLTFVPILFLGRFTNTFYTVLSAIIVALINVLLGNDTVIAAVILVVIAIIVGAVGPFLK
QNDIISIQILNAIALIIFAILSLISPYYEFKEVLYLIPLSYVLSIASSFTFVDMWHFFSL
VNRYENEDKLDYLTGLGNVKEFDRHLNEVTRIAETNNESLGLLLIDIDGFKDVNDTYSHQ
SGDAVLRQIAQLLKNYVPQQFNIFRNGGEEFSIVLNDYTLDQCVKLGESIRAGVEQSTFH
LPNKEVIKLSVSIGVGYLTQEDYKSQRKVFKVANDMLHMAKNEGRNQVMFNPIVKL
>A0A7Z7YQ67|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAH
PGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A5W2LX95|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lattenkamp|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVSDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9Y9C2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRRLRFPRKRIDCLPFGRGHWPVERARDCRKMDERASKPPGLLPLSREDLEKTLRYALEI
VSDGIWDWNIATNQVSRSAGWYLMLGYPPHSLPESVETWKSIIHPEDYPRVMASFQAYLD
GEGPEYCEEYRCRTYSGDYLWISDRGRFVEFDERGEPRRMIGAHHEIHQRKLVELELQQR
NEELFDWNLRLEELVAERTEALHRVNQALASKMAEAQRLSEIDPLTELYNRRKFEQCLHH
EWMRRQRHGRATALVMIDVDHFKRINDLFGHSTGDRVLVAFGRLVASELREVDVLARWGG
EEFILLLPETGLEAAAALAERLRQRVRSQSFEMGERLTASFGVGVLNDGETLDLLLCRVD
DALYRAKQRRDCVACC
>A0A069A8S5|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPEGKVCWQVLYPEKNSTC
SFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQDGTVVHMHQSIDIANSTSL
NKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDALIRGTDEYIYICNMKTGVFRY
SPSQVELFDLPGEIVENPLVYWKKIVHPEDWNRFYKSNTEIGKNQMDYHTVEFRAKNRSG
EYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKIDSLTQLLNYHEFMSVFEDKISNPMI
EKLCIVLLNIDDFKNVNEMYDRDFGDNIIKTLAQSIQSILPDNAELYKLDGDEMGILVDN
VEENEILTLYNQIQNMIIHLQLWRKYGLNITISAGCVIYPKHGDTVKELYKCASYSLQYA
KEHGKNRLVFFSQEILKNKMYSLEMMRDLKASINDDFRGFSLRFQPQVDTESHKIIGVEV
LLRWTNDKCKAISPLEFIPILEENDMINIVGAWVLRMALRTFRKWIDYYPFFKVSVNVSA
VQILEDTFIEDIVKIIDDENFPYQNLVLELTESHTVQNMSILQFKFKALQDLGIYIAMDD
FGTGYSSLEVLKFSPIDIVKIDRVFVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVET
QEEYDLVKQIKPDYIQGYLFGKPQTATEIFDLLKLDN
>A0A2C9CCP1|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MPCISSNNPDSERPKQFVATQSAVTGRKDKRIMFYTLIEQIPCAVIVTDIKGTIEYVNSQ
FTELTGYTREEVTGANPRILKSGRTAPEEYKHLWETITSGKKWKGVFCNKKKDGSFYWEK
ASISPLMNEEGMITHFFAIKEDITIQKQNEQRHEILYILSNILMESVSVDEAIPKILQTI
GEGEIGRQIGVDRVCLVLSGTNNGMADNVYEWCNEGIPSQRRRFMDVSFFAFTWWMKHLR
AGDVIHIPQVCRMPKEAAAEQEFLIKREVKSVLSFPVFADKDSFGFISCENILNGCSCKE
QDIMLLRIVSEIIGNAIVRKRSEACIQHMAYHDALTNLPNRNLFRARLEMAILQAKRNKK
MAAVMALDLDGFKAVNDSFGHHMGDLLLKEAAVRMKECVRECDTVARFGGDEFMVILTNI
NHREDANHVAKKLLGLLSQKFLINNDKIGITVSIGISLYPADGNDMEDLIKKADNALYCS
KKEGKNTHR
>A0A3Z0CBG9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Haifa|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSALEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A726AQ43|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis PT4 (strain P125109)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A2I5HF33|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3W0FDY3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Litchfield|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A433MRB7|diguanylate cyclase|EC 2.7.7.65|Variovorax guangxiensis|TrEMBL
MESLIEQLSDSVASARTLEDLTRPMLEMLGAVTGLESTYLTTIDLDKGQQHILFSRNVRQ
LSIPEGLTVPWADTLCKRAMEEGRTYTGDVASCWGDSDAAKELGIQTYVSTPVKTEGGDL
FGTLCAASSTQQPLAPHAEPVLQLFARLIGQQVERELLYRKLEKAHAEVVTLASTDALTG
LPNRRTLVDGLRRLMAQAERDGTSVLVGFIDMDGFKKINDTHGHDIGDEFLVAMTARMLA
SLRAGDMLARNGGDEFVVIGAGPAFDQAPNAAARSLAERLGESTVGELRLQGATLDYRGA
SVGVVAIDPRTTSAAQALRLADEAMYSVKRGRRAVANHRETASA
>A0A5I1E7G1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agama|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A202BAU6|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSFVFTPLAALSGLAALLAAAISVIAWSRRRFAGVRWLALLMASVAFWAAGAMCELSVTS
IAAKLFWSKVEYLGTLSTPVLFLLLALDYNHLSLRRRALALLFAIPAICLLLAASNEYHH
LVWTRFQPSPSGYNLLVYGHGPAFWLGVAGYSYLMMLLGSLLLIRALHYFPAHFRGQSLT
LMLSAIAPWFGNILYLTGAFPLQGLDPTPHSFAFTGLIFAIDLLYLRQLHLVPVARARAF
EAMGDGVVVVDHQLRILDINPSGAGMLGGAPADWPGQPLPAPWLEASMLAPGAHLELMPP
DGGRILDVRIYDIEPFHKPARTRMLVMRDITLRRQAEDALREANLQLTDRLAQIEALQAA
LREQTLRDPLTHLFNRRYLDETFERERERAEREGKPIAVAMLDLDDFKRINDRHGHQIGD
RVLQALAGLLRQRSRAADIVCRLGGEEFMVVLPGSDAEQAQHRVEEWRRAFHQMEHAGEH
PFRASFSCGIAALPGNGRVLDELYRRADQALYQAKAAGKNCSVRAGRG
>A0A426WPB6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A447NTM4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGILVLSVLLLIW
HGKYGQKRINLPFISILFGGLWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLHSLPSVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFTLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQALGSYQHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDIVCRFGGEEFLVLLTAAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDVRAI
>A0A059ZJ15|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIGSFAGAFTGYMIADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGALFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKNHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLGNTISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A3U0CDU4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7G6KEA3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSIPIHLPDGS
FYGALCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A3T5MRW8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGAHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5F1I2R9|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MFPKIMNDENFFKKAAAHGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLSGWWWLVLVGWAFVWPHLAWQLASRAVDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLKSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
RAGRNRTEVAA
>A0A486NH04|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLTQYQQLQQTDKSIEQRLAGLKDNGASREELALLQDGLQIAAELQN
EQQAALAHVAHGDAPAAIAVLYGNAYETELERMQTQIDRFRQMLENRAAVAIDQATDRSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLERQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEKHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A8E2C4X9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGNSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A7I6WM95|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A0D7M398|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPENDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSRAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIHDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIYQE
>A0A8B5ZZT3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDSHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAAIFVPLASVLVSQF
LSGVWWLLLVGWVFVWPQLAWQLAFRSAEPHSSEIVNLKIDAILAGVWMGLTGFNALPTA
ALIMMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSAPLALWLTLPVLVVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRYEFEACRRSHRQATI
LLIDIDHFKAINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPTARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A3V9S4Q2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DCVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8B3UTM7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MSDIILARVSETLSTEQSLDSLVRQLLEMLEIVTDMESTYLTKIDINARLQHILYARNSK
QMQIPEGFSVPWDETLCKRAMDSDTLFSNEVPDRWPECEAAKALGITTYMSVPVHLADGS
LYGTLCAASTAQKQFSERGEQVIRLFAGLIGQYIQKESLVLQLREANAALIAHSYTDALT
GLPNRRAIFENLTTLFSLARHLSRNVMIAFIDLDDFKRINDQYGHEAGDRFLVQVGKRLT
HEQTQDEIIGRLGGDEFLVASLSHSVDGDASTEINAIKTRLNGLIAGEYGLGNATILYPG
ASLGVVIVDPHSTDEDSALRTADLAMYQDKKGKSKTGFVALD
>A0A3W0K6D4|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0J6VGA5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MERLLRSVEHYDWITDFLETRGLKDRTRFWLAATTAAMTAGVLTLLFGAGHPNSAIGRTM
MWLAVAGGVFGTVLFLWRWPSRQWSQVYVAATTLSITLACLAYPDPLAALLGCIAFATVV
SYAAFFHSPRVVLGVLLLVTGVAISQTVAVSLQGRPAMALVDLFLILQCSYGVGLTFYTL
VRTLRGDLAIADLDPLTGLLNRRAFRTMVQTRILHHRDDEGYLLAALLDLDRFKAVNDTR
GHAAGDQALVAVAEALRSTATSSTVIARSGGEEFLFADIVASEDAALRYEQVCAAIAGLP
CEITGSIGTALVEVSLVSEDSFDVMMDQLITAADKAMYDAKHDGGNQCRHHGSVI
>A0A5T7FTS1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MFPKIMNDENFYRKAVEQAVTPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGGDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W3F8B3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDIMGENSHFVCRFGLWLNN
QSRYNEDDCSYVSKISATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDVLTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACLAGLRLCRLIGQKKIPY
ADGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENERIALVDTND
GTSYPLSA
>A0A3A3N547|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S0FS76|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MALHSKKLSFTRPIMVSFAGILFSFAIIAILVILSQRKDFIEDYHKINGNFTHNLAVNYT
ESILRENDYILGRAAMYYARDDRVNQTINIDPAQGLQMLMHLQNLMPTVSSISLADTEGH
HLRAPEVLPTEKSRSFDARTRPWFIGQAEASNFPHYTRPYLDYFTQHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLFDPKSKTWYYYYSFTNPDWFVIYRVSDATLSVITRHETTVVGWGFALAAII
IILFGLYLRHASRSVLMNIINAIKTGDVNQAPRLEAMLSHTIRTNKEREMAYVRQATHDA
LTGCKNRRAFDNDVDELLTAHQPFVLALVDIDNFKSINDTWGHLSGDIVLRSVAREGIQI
MQPHHVSVYRYGGEEFGVIFPAELMNSAHALLEAWRTAVEKRTWREENLRVTFSAGVGEW
HFEPLEQFIGSVDEALYTAKQQGKNRIVSTASR
>A0A486QLB3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVAHFNQQAANPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A2X3F3A8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGGNGGLAAPAAGQ
KRAAVAQFVTRSVDRPG
>A0A8D5PH85|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6C9EJN4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYASFFLTNSAPMLLIAPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0D6IMG6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISSLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0V9GF68|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLIVSLNNENADISSLRERIQQQICGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A6N8MBD1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMFQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A828NU84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTWTTINIVEAVVGAVLLRKLLPWYNPLQNLADWLRLALGSAIIPPLLGGVLVVLLTPGD
DPLRAFLIWVLSESIGALALVPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSML
YLPWPFTFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPW
LPFLLILLPANIMTMVMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKA
LCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWA
LLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPN
IFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRIAVK
DGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVC
IDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQ
DVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHL
ANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSM
LRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITL
IDGNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQAAAHNERAAISLDEQWRMIKENQ
LMMIAHGIASPRLPEASNLWLISLKLWSCESEIIDEQTFRRSFSDPALSHALDQRVCHDF
FQQAAKAVASKGLSIALPLSVAGLSSATLVNELLEQLENSPLPARLLHLIIPAEAIFDHA
ESVQKLRLAGCRIVFSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQ
GHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A5F1E503|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHAT
GDQVLIEVAKRLAEFGGLRHQAYRIGGDEFAMVLYGVQSESEVQRICTALTQIFNRPFDL
NNGHQTTMTLSIGYAMTIEHVSAEKLQELADHNMYQAKHQRAKKLVK
>A0A826T5K5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQLFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A1Q4PP80|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANQTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>E2QIK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKSVTGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDVYFQVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A148HKM4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A090HRI1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A229J3X2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A6G2HRK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDQFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3V9X1D5|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A376PVS3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNADPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2I6FDQ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYEFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1V3VTQ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYEFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5J1IMW4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sandiego|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0R9N0L2|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3Q0MZ47|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELAMLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A827RVX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNADPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIHRV
>A0A3L2NMU0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIIENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0U4BFB2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A5W8C5C2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Colindale|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C5WDI8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKQEKEKELWGNCDIEKDMSWNMYQILVITAVSANLIGTICNFCIHGTELPTILCGVCLL
MILIIGCAGWITQKVQLPAVVIILILSWFEFPYLYYCYGNTAIVYLILGIVGLAVFFPRS
MVIASYAFTLLEYLVIMMISFERPSRWSNMDEIGIIGTTLGSFIIVAFSVFTMIFVLLKR
YEEQRKQLLTLSENLEFAANHDPLTRLYNRRYLVKQVDEWMRIPGKNFWIILMDVDDFKV
VNDTYGHGYGDDVLREAGRLMLEEMLGKGIASRFGGEEFMLVFEEDNREQVLQAFQNIQE
GLRKYSQATKQTDITISGGMERYEADKQMDLLFTSADRKLYTAKNNGKNRIVE
>A0A5Z9ZRI4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Gaminara|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5C2HGY4|diguanylate cyclase|EC 2.7.7.65|[Arcobacter] porcinus|TrEMBL
MSLFLVQYQNEFFLILILLIIFIFLVNRIKYIDKIEKINKELMKISSIDYLTKINNRKSI
DYFLNENIKIFERYRDDFSIIMIDIDKFKDINDTYGHLVGDNILIEFSELIRNSIREIDI
LGRFGGEEFIVICRKTKIDGALKLSEELRKKVAKHNFAVVDEITASFGIANYSAKDNLYT
LLKRADTALYLAKTNGRNKVELIR
>A0A3V5B2Y9|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARNSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A623XYI2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A344S7I9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A0H3YRL1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSAMRYETDERSLQQLVTRRFAMASVTYGLALLLTWVAVASGFYEAPIASAVVHSALIVV
SQLMFFWLFHRGINLRFKDPSLTEPQVLVGLIWLTYFLFNLGSARGSLLVLYLLVLMFAV
FLPPKIFIRYASLAFLSFVGLAALDYYLERPMDTTALALQASVLLVTLIWMCLFAGHVYR
LRQRMRQRRYALQAHQDTLRGMMRQLEDLASTDELTGLYNRRRFLRIAEGDLSRLRKGHQ
SGLALIDLDHFKRINDIHGHATGDRVLQTFAKVARSCLRDDDVLARYGGEEFVLLLPETD
AEQFRACCERLREAFASAEPEDAEIAAGHLSLSIGLTLLNAGDELDAALQRADEALYRAK
RAGRNRCEAAWDTCDA
>A0A5T3LX68|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V1QHX1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKFADMALYKAKN
AGRNRTEVAA
>A0A5V3NSS3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Z3LET1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3Y8PLE8|diguanylate cyclase|EC 2.7.7.65|Salmonella virchow|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5H8WNA7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5W0TA62|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3AE22|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKNRVKKQAVKSAEALSYSKVRRAFIVCLFLGILCFLLQNAFLAYTNMKQTVKTIQQSVS
AQISEKVNESLKLLESLASLDLFYEPDTPWEEKVAVLDKINEFYGYMFICFVDQDIVVYT
LGEEPASLASREHMQKVYASKQPYVTDSFVAGADGKTLNYTVIVPLLKDGVMTGSLFATI
VLDDISGLLNKITSTTKAEAVLISSKGLVMCSTNNLTYGTSILDILSNYKLLHTTANQLE
EQMLNKHFGSFQSYNGFGLTYTEYGPVENSNWDILVTVNFWPVFLSMLPSAGFAVLGMLL
IMAVLYYFVNRHARLQSQTIENMVKSVQQIKRKVYQGNDPSEQIDYENIIQLSSKGLNDD
LTGTFTRVIFLDRAEAMLKDKQDDQILALCFIDLDNLKTLNDTNGHSAGDMALKKIGSIV
REYGVKYDGIAGRYGGDEFILILRDIDNHDELNTVLKELVDRLKFIIYCEDKEIEIHCSI
GASIWHKGLTLETLISNADKALYNVKCHGKANYSLFLNGGHDEI
>A0A5V6NI97|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Poona|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A853SAI9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MRVPDLSSLRRIAVPLAFGGNSEQQHTYFAELHRVGMVTQLLGIIAYSLTWLMMPEPYHP
NFSHAVLALLGMLTSLIVRYRCTTLPVLTITGACAVLTLTFGLRTMADAVHHASFWVLPV
GVFMTLAIASIFNGGLSYLAVVAGVWWNVGHGLYPVNAGLPDQSWAPLMIAVSILFGLAL
NVSFSLLRLRNYHSKLELTRLAFQDSLTGLNNRRMFTQRAQQMHGAPHGGTLYFLMIDID
DFKIINDQQGHDAGDEVLVRTAAIIAGKAQGHLCGRLGGEEFGIVYAGNREDAGAFAGGL
VEAVSQAFHAAQFVSISVGVAELDRDKDLGHSYRLADEALYLAKRQGKNRYVIA
>A0A653WU72|diguanylate cyclase|EC 2.7.7.65|Bosea sp. 62|TrEMBL
MMPGMNGFEVCRRLKNSATTAHIPVVIVTALDQPSDRLKGLDAGADDFLTKPIDDIALFA
RVRSLVRLKSVTDELRQRALASRQLGIADPLAAAAAETGLNGRVLLIEDRPLIAERLTQA
LSAFHSIETETDAQAALARAAEGDFEIVLVSLDLQNYDGLRLCSQLRSLERTRNLSVLLL
GEAEDKSRVLRGLEIGAHDFLVRPIDRNELLARARTLVRRKRFAERLRDSVQSSMEMAVM
DQLTGLHNRRYLDSRLATLFDESALRARALSLLVLDVDRFKVVNDSWGHDAGDEVLREFA
DRIRACTRGIDLVARMGGEEIVVVLPDTAIEAARAVAERIRERVEGEAFQIQRGQRAITV
TVSIGVASRRAGDAGPVEMMKRADEAVYRAKAAGRNRVIVASAA
>A0A381H2I9|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MSALITLLFTSLYLFIIYEQRQAVVNEGMSRLQTRMMDIFNDNELIADATGVRYHQIKNA
GQCGNLSRFSPRDADSWGINADRARIHSATGTIVSRQPNINALCMFAAAEFIRDRMNTLN
PGDYAAHRYIIAKDASYFYWFTPADAKPFYFSDSKMAGDITDFFLPPVGFYTRLLQKNVK
SKSLSSTDFYTDKITNEKAYSVVSYIYDLSGKEISDHIVAYLVYDHSKPELQEALTEAFE
HHIPPGLNVALVHTPTQENLCLSGDCQPVAGESIRAMSAKYAFHSSLSLHRFVRYDTQAG
IAILLAPFFFILIFLGLKFWLNASDLKVYIDSLTGCFNRKILDIVKRRDLTRSCVVLLDC
NKFKAINDTWGHVAGDRALQIIANRMLSNTRTSHDLVIRTGGDEFVILLYRAQIGDAIAI
AERITGQINDYAFMVDGHVVPLSVSWGVAEVTRDLDTAIQHADNEMYKMKQVRNDGIGPI
SMALSGLLPAQYYARVAAFIAVTKRFQLGQHLPGGLRRFSQ
>A0A447UVG6|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MKLHHKALRLFISASVIVLTSSFLAYELIASDRAMNAYMGYIIEKADSSFLYDKYQNQSI
AAHLMRTFTEPKTPPSDEQQYALCRRFETGRNTHGINLTTHNNPSLHGTLQTAEANCAIV
ADDAPLLFAFDQAVAANRNQKDYGKGLGTVEDKFHYYLDIKKRYVYFYNLIDSRQFFMHH
WSFLRKGTLGINRNDIDGQFTGRTVLSSIYQDDLTEKNVMSFLTPVYLHGKLKGIVMVDI
NQDNLKNIFYTQDRPLVRRYLDATLFDLNSEKKIIVHQSENNLFNYVNYVHDLPGGIRVT
LSLDILYFIVSSWKLFAFYLLVTATLLNMVRMHFRLYHSVNRENISDAMTGLYNRKILTP
QLEQRLQRLVNTGTSVTFIAIDLDRLKVINDTQGHQEGDRTITLLAKAIEASVRKTDYAI
RLGGDEFCVILIDSIVPATTLPERIANKLRIIAPDKVISFSAGLYHMQPEDTIQDAYKAS
DEQLYLNKQQNHARL
>A0A447UFA2|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MAQDNRKAKHTIWTTREDMVRRGMALSLPWFAFVNISFALMIFFRDALFHDTHARYLAEM
RIVRTIDDAVIGIMLVCALLLITSRRQSWLTQGLLITLSLFWSWCSYYFISHWQLTFAYP
LCAVLLLSAVIALYFHTPSVLAFLLPLWLTVPVASVVLNQKVNIHFAVIWGIFSLILLGG
RFMLIRWFDEAWRQNQHNNLLISRLDNLAHRDPLTGTSNRRAMEKLLHSATAQQNAFALI
MLDVDFFKRYNDAYGHPAGDACLSQVADILAQSVRSPEDVVARYGGEEFAVILFDATLQD
AERVAARIQQALEAAAIPHPASTVSDSVTVSQGIACSEKGKTAEQTIADADAALYRAKEA
GRNRWAR
>T0PLF8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MRFITALALLWITQLQAAPSLLEEAELQAARDPVGYLQRLDANPQQDMELFYARALAQAA
LGHYPQALLDNARARELASAQQQPLRLLDFQLQEVALTLDTEAPDKALRLLARLKPAVID
HPMQASEWHALNGLALYRTQQLKEAIAELKTAFRLKQSARDKPVASLDSARLLMTLGNLY
ADLSLPREAETYYREALQQMVQLDEPNSQTIIKANMARLYIDTDRPTQARQLLDGLLATP
HLAPDYRAIILGYQAMALNAQGDWTAALRSLDEAQALYQQLGYQDAGERLLETRVKALQG
RGEIQLALQLLTSQGHPSAGSKALQASLLAQQGRYPEAYEALSAYMNDYKQHFNQALSQH
AATFQAEMDLARSEANNRVLQEENERKRQQLLHQQSARNYQLMLVGLLAGALLLLGITTH
RLHRSSRHLYKLATFDQLTELPNRRALLERLAIQWQLEDPLTLLIIDIDHFKQINDRHGH
QAGDRAIQRLARELSDWAPDAQLIGRWGGEEFLVAVPLAAEDCWHLAEQLRLRISQLDTP
HMTISIGIAGRSEADEGLGPLIHRADMAMYQAKRQGRNQTILATTPSAQDELTSSVA
>A0A8G4AB70|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERALSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSLLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARFGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2T3QJX8|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MATLVKSTQLESVNFAYIELSKNTLQRQLSLLFTSSGIICTLVAFAYFVAKTSLVSLYSA
LLGLSISYTLAIFNRININPKVLMWIFILSTTLACITGYSFSETHHISNTIGLTIPLLCF
FALKQKTAAWYSGLFGFCYVILSISEIGEKQLQLNDALQNMSAYSLVFVMAYLLAKHRNE
AIHCVKQTATNDFLTGLYNREGLLPIYQAEAARSERYLKDFSMLLLSVDDFKNINDRYGL
ETGDKVLMMLTKCLQQLSRKEDTIARLGGTEFCLLLPDTSLEQAEKFALRLQEQVNSWVL
ELESGHRISVTLSMGLTPIQFREFNYDYIKADNAVMRAKHWGGNQLAISE
>A0A6B8MYJ0|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGKQGQFSRAILVDARQKPFASWHNDGLARQDRISDVIS
KWLFPKPTVQTIQHQGKMIGELRLTALDRLITYFLGISILVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQDK
NAQLLRSSLHDPLTGLANRAAFYNVINELMKDESVHSSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVANRLMAFVGTQHQAWRLGGDEFAILLRNVHSEAEVQALCSKLSEQFLPPFHL
HNGHTVRLTLSIGYALTWEHASAENLQELADQNMYRMKHQRLQQTQK
>A0A157SM15|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MTRILIRPDLRHLILWTSLIIFALALANTFVAAYRVQQSALLANTLELNRVYATKVAQAT
DVFLGGARQLLGAGADELSGKSDLNGQSAKLVVDRLSRVTNTFNSLIVIDQRGLVLATIP
ATLRLVGTVLQSDETRRVLSARAPTTSEPYRAVTGRWIVTVSHPVFDADGRYAGALFGTI
YLHERNALHTVLAEHDFTDGSLLYVVDKSGRILYHPDNAKVGEQVGKHPAVLLARAARTG
SARVRDDDGIDELAGYARMGSTGWTVIAQRPTAVALDVVQEQFGRMFLFSVPIIALCLAG
IWWLAQFVSVPLRTLADAAGELGSNQAADRIRGVNGWYFEVEELRGAMLRAASAVAGRIG
RLKRERASDPLTGLLNRRGADEALIDACNQNASMSVVLMDVDNFKKINDTRGHAAGDEVL
RGLAGVVRAQVREDDIAARMGGEELAVFVPGVDREDGLAFAERLRHAVEAALGGVTVSIG
VARWPDHGSTLDAAIAQADQAMYEAKRAGKNRVRSAP
>A0A1V6GAK3|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MIIREARESSSRKKAVVPEQSRNRPLALFTESIMSLLTSRHTDGAFTDLVSLMAQTFPLA
APALYVDTQGPEPRAYSALDANEGGDRDAVRVLGARRYAYTRVLAGGQAPYGPSRVDIAL
VKGPHATVSLSVNPGGHEGIFYEWVKYLTPAIAKLMDNELLLNMAFRDGLTGLLNYRAFS
EILTTEWERARRYKTTFSLMMIDIDHFKRINDENGHPAGDQVLRSIASRLMSRLRKSDQV
FRYGGEEFMVLLPQTGVYKAGLLAERIRGVVEKMRFPGGVGVTISVGVSQYEDGRTVSDL
VKQVDTGLYLAKGKGRNRVEIYKDLQR
>A0A8F6HAF0|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas indicatrix|TrEMBL
MDEATRLREIERLGVLDTPPEPVFDAIVAAARAATGMPIGLVSIVAEQRQWFKSSIGLGD
VSETPRSISFCTYAIEQDALLEIPDARQDPRFAHNPLVTAGPRVRHYAGIPLATAHGARI
GTLCLLDTLPGVLSPSQRELMVHLGRVTTQVLEQRSALLRQIDQAQALHRDLKRSEDFLE
RTNTAAKVGGWELELATREVRWTRETKQIHGVRSSYQPTFESALSFYRPDSRSIIQAAVQ
RCTEQGTPWEVQLPMTTADGRSIWTRVVGTRQQVEGLPRLVGAIQDITEERAVVDALEAS
EVRYRRLFHYSLGLICTHTLDGTVTSVNPAAVQSLGYPESEMVGRSLCDLMPPEKREAFK
AYLRRIEANHTDAGVIELLAADGTRRYWAYNNVLDTETHPPFVLGHAQDVTALRLQEERL
RELSLKDPLTQCHNRRYLHRLDDVASRSWACLVFDLDHFKQVNDTLGHRRGDTVLVEFAD
FLRAPLRANEAAVRLGGDEFLVALIEPAAGRLAALEAWYAGNAARAPTAFSMGAAVNVPG
EPVAETIHKADSRLYRTRARVRREMRPPGSAD
>A0A178GJS6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SFD|TrEMBL
MDNECMARLAEQWKQICQNYSSDNLLHAFQFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQKRLRDTLNAWLLESFSVGINKRYADAVQKQALVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPEQGMLTTCSYIIQIMGFATEIMCRSYEAKTALNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFVHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMNCTDKNNMLGLIQKIRNLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEGLQKYS
QGSDYVFRIGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSVQGHQFKFTVSIGCAL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSVNLAVQPLSV
>A0A1V6KFA4|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin002|TrEMBL
MILHPRTLHRIGPFILCLVLLWAITAQAGEAPPIRVGGAVPAVEIASQSEYLLDYSGRLQ
YQDILSSGQPFQRHTKYSFQFSFKRATLWFKCRIAPADSGDETALASRRSFLVFDNAALG
AVTLYVPVILDGKPDLIEFHGGWRQGEKSREFPFLYPTFVLPDNLDASRPVVVRVATPYA
LQFRATLYTIDAFRKMSFVLFLIVGFFAGILIAMILYNLALYLFIRDRQYLFYITYIGFL
LLWQCVLVGLFQYIWPPLGAFLMSGIPVFAALMMIFAVSFGIVFLNTPKTAPRHDKLLKG
LAVFIGTIIALVLLRQLWLGNLLSYLSGQVVSVVLFTAALSSLRSGFRPALFYLIAFGVF
LLCAFVFFFKFYGLIPNNTFTMHIVIFGSAAEAVLLSFALGYRIRVLQEEEAQLRERERD
LEAISVTDELTGLFNRRFLNPALVKKTAAARRSGTRLSLLMLDVDHFKDFNDTYGHPEGD
KVLAALGGLLIQTLREEDIACRYGGEEFVVILHNADLNAAMEAAERIRAGFEKISFRPDP
KKEIFATVSIGAAELLPQETPEQLLFRADQAMYQAKQTGRNRICSA
>A0A8F6DCW9|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas indicatrix|TrEMBL
MGGQGAGRRRAGRHAENIGRLLQVGVLWLLLAITTPLAAQSGAPPLRDYAIDVWTSRNGL
PHNSLRDIAQTPEGHLWFATWEGLVRYNGLDFTVFDRSTRPGLRDNGIGALLVDPQGGLW
ISDSRGNVSHRGSDGQWRVWEHQPDTPQVLIQSMQMDSQGRLWLLYEGKGIGYLTPDKGI
VYQRPPSDLPLAMSFTKMAVDAQDRVWIGTLDGLVLRDTAGVLQRAPAAWGVDKGLSWPY
RAPDGTLWIVAGERLYRVEDDRLVLVHRLPGQLHLTAMLQDRHGDLWLGTENQGLLRISA
HGLERLPAGLNLPGGRVVSLREDAEGSIWVGANGGLYRLRETLFSSYTERDGLSGDYVRT
VLEDRDRHLWVGSASGLDLQTADGRFRAIPLHNRGGKAPSVLSLAQDAGGDLWVGTFGDG
IYRLHADGRLRHNYAAADGLPGGNIRAISIAPDGVVWAGTQKGVVRIEGDQVTVPTVAGM
PGGLTTALEHDHQGNLWIGTIEGVRVLRGDRVQSIDLAPLGGGRSVFGFHQIGDAMWISS
DRGLYRWQAGTLARVGLEQGMPVDAVFQLVPDRLGNVWISSNRGVLRTDMATLNAVADGR
APRVTVERYNEIDGMANAQANGSSGPSAILRQDGTFWVVTAGGLSTVDPQRLQRFRERPA
PPAAIENVQVDGAPVHWEGPERNLIPGGRRLAVSYVGLSYLMSDRIRYRTRLEGLDNGWV
ERGPQRSVEFVGLPPGDYTLHVAAAHPGGSWGHQEAVWSFTVEPFWWQRHSVQALIGLVL
LSALVALYRFLLQQYKASNLRLARRVDEATFDLQAQTVHLQALNQEKTELAERLARQAEA
FERQAREDALTRLANRRGFDEALARDFARAQRSGHPLCLVVLDIDHFKDVNDQHSHSIGD
AVLVEVAQVIAAASRDSDLPARTGGEEFALLLNDTRLEEAAQLCARLRGLFHDHPDWAGI
PGLRVTFSAGLVELDGDDRTPALLYQRADRALYRAKSDGRDRTSIG
>A0A510X7R8|diguanylate cyclase|EC 2.7.7.65|Halomonas pacifica|TrEMBL
MHYQDYCQLVAGWQQLLGRFTDSLRRQVEAIVAANTEELASHFYATMLEDPHASLFLSNE
QVKQRLHPSMQRWLTSLFAVGNTAGEALESLIRQQEQIGQVHARVDIPVNLVLSGARHLK
QRLYEFFAEQLVDPALGGQAAIYASDNIDMAMEIMSHAYSLANDRNARTEEAYRLFSLTQ
NLGSERERQRAALLDWENNLMFAVAAAQDTEALPRLGASEFGLWYHHKAMHAFEGVQEVR
AISETIARIDQSLLPAIAGEDRQQAMARLTEIREGTRSIHLLLNGLLERAAGLEAGRDAL
TKLLNRKFLPVVLNRELEMSRAAGKTFALLMVDIDHFKRINDTHGHEAGDQVLQQMAALL
DRNTRGGDYLFRLGGEEFLIVVVDTDAERARLFAERLRRQVEAEDFLVAADTLIEVTVSL
GLALHHGHPDYQRLMRSADEALYQAKHGGRNRLVIATP
>A0A7D4X7T4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. FDAARGOS_724|TrEMBL
MNNECMAMLAEQWEQICQNYSSDDLLHAFQFIQDHSLVLVEEFYKNMLLEKEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
MFELLSLNPQPNMLTTCSYIVQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
QIYQIDTLNQAVLECTEKDQMLNLIQSIRDLNREIQHLIDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDSDERRALNIAENIRKYVEHGLINTAQGQQFRLTVSIGCAL
FDGHPDYQRFLDAADAALYMAKNTGRNRVYLAQPSQIQGAQKASV
>A0A7V8SLB6|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. BIGb0393|TrEMBL
MTLEILTSQHAPQRIWLNALIMGGLAFLLTLFCLELIVVSGRISPLWYSTALMTVLVFRA
PSKRVPLLLLACVMGTALANLIIIGPALSNIKFAILNMVQAILGGLMLRALLDRRAPLNS
LLDWVRFALCAGLIAPLLGGVVALWMLHVGNNASLPFFSTWVISEVIGVLAFGPVLLLWP
NKPLRQLITPGRQLETCLTLLGTLLASYLSLRFLPWPFTFIVVILFWCAVRLPKFEAFLL
IFLNASFISILLAFNWVNLAQNGLLLGQANTWLPFLLVLLPSHIMALVMDAFQREKHHIS
ESETRFRNAMEYSAIGMALVSPNGGWQQVNQSLCQTLGFPADELKKLTFQQITHPDDLNS
DLQQLERLIAGDIMTYTLEKRYFRKDGEIVWARLTVSMVRDAALQPHYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYELFGLSPQQTPTYDLWVHL
LDPAERESAALAVQQAIERRSAFQLEYRINLPEGPRYVRSEANRILSQDGHIERMLGICQ
DITPLRALNEALFQEKERMAITLDSIGEAVISTDDEMRVTFMNPVAETLSGWSQEKAAGV
PITELLNITRGAAGPRVDNLLLCQLPGEKVSPDLDEELVLHTPDGAHVEIHYSITPLKTL
TGASIGAVMVIQDVSESRKVMKRLSYSASHDMLTRLPNRHSFEQRLKQLVHDAATHKTQH
VLVFIDLDKFKAVNDTAGHAAGDALLRELAELMPHHLRSSDLLARLGGDEFGLLLPNCEV
DQVRDVVQRIVAAVSDYRFIWQDQPYHVGASAGITQIDEHNCISNVVMSQADVACYSAKH
AGRGQYHVYQEVQM
>A0A173S487|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MKRKIAIIADGWRRHITYVWIRGCRNYIKEHELDIEISVFHSFGNFSRDEKFNAGEYNII
HLPDLSQFDGIILEVTNMLNQKKRQQIIRIIQESGVPAVSLLEKIPGLYHAGLDNYATME
QMVEHLIVAHSCKTLNYVGGPAESQENLLRRQAYEDVLQRYGIPLENDRIWNESYEVESG
VRAFIHFQEKHLLPDAFVCANENIAVGLCHQAQQEGFKIPADFCVTGFDNFDKASYYRPR
ITTVSYEREVIAEAAMDLLVQIWGQNTTADCKTVPVQMLFQDSCGCKPEQVRSRSEYIED
RIFQEVREIDLHNEIMELKHNLIECEDYKQMAQYFTKCVCGLRCKGVRIWMNQDLVEESL
SDSTGEASYITDGYPDTMHVICEKGMEQEYSLYVYVPLHFREREVGYVVLADCDYMLENQ
FLFETMNTYLESLEYLYRKLRLRKANEKLSRLYVLDSLTGLYNRMAYQEFAEPLYEKCRL
QKKAVTVMFIDADHLKYINDTFGHDMGNLEIRGIADVIRKVFPPEAVSMRYGGDEFVVLL
PGCEKTQAESLKAAFLKALDEISKSLHAEFDVEASIGYEVVLCGEKSLNECINNADEKMY
QFKKARKAQRK
>A0A807LIK2|diguanylate cyclase|EC 2.7.7.65|Kosakonia cowanii JCM 10956 = DSM 18146|TrEMBL
MRHSTFNHLPGQSNNAGRYFDPTWVVNLCFVIVMVCSTVLTWREVLVLENAYATSQRSAL
ENVSNALDMQMQVGVERLLFFRHTMEAALQTPLDLNVLRKRHGEFDSKRVLPQWQIGRDN
QRTLPVYGVSDYFVEQTALLTRDNPNLHNELTAAMELGYLFRLSTHAQMLPRRAWYISRA
GFFITTDTQASEETIVPTYYRLLMRPWFIGQQRQENHGRGVRWFSDLTPGSEHHGDVTAS
VPLDYQGNWLGALGVSFSVDAIHALLMHASPGGESDEKGNYLLYDSHFKLLTTTSLDDNV
KPAFNPEERARLSAEMAKDTVGGLRLGARYISWQKLKHFDGVLVRIHTLREGITGDFGRI
SIAMAILWLLFMTMLLVAWGVIRRMVKNMYAMQNTLQWQAWYDPLTRLCNRGVLFERAKI
LSQQARTQKQPFAVIQLDLDHFKEVNDRFGHQAGDLVLSHTAGLISSSLDDKQVAGRVGG
EEFCILLPGCTRAEAAAIGERIRLRIASKEILIHKHTTIRISASLGVSDALEEGNYDFEH
LQSVADRRLYRAKHQGRNQVCADDEMPNS
>A0A2H5VVW9|diguanylate cyclase|EC 2.7.7.65|bacterium HR09|TrEMBL
MVHRVLLDHEGILWMGTEEGLGKLVPGPFLTFTTADGLPHSFVRAIAEDAKGRLVVGTRN
GLAVGERDGSLPRFRSVFTERRGYAILQHPSGDLWVATNGGVVQLRNDQTARIWQEKDGL
PDRFTFALAYDATTDELWLGTWSGTACLKRGKLVPLPPPLASARPLSMHVDQRGRLWIGL
RDGKVLVRERNGNTKVLGAAEGFSDQVVWSIASDEQGVWLGTNGDGAFYVSDRGISRWDT
SKGLVDDFVWQVLPDKKGRVWFFTSQGLDRLEAGNIRHFGAHDGLPDLEGSANACWQDSR
GNLWFGTGSGLVRYDPQAENKALAPPQVLLESATFGNGVAVQPGKQLPSTHGRVVFSVVS
LALRNEKALRYSYRLLPAQPSWSPPQAQGEIAFAALGPGSYRFEAVALDADGQRSETPVA
FEFSVARPWWQSPLFFMALVLLAVGLTVAYSRWRLARVQARARELERLVKERTRELAEKA
LELARLAETDELTGLPNRRKFFETLRSELQRLWRAPQETRLALLLVDLDNFKDINDTLGH
TAGDLVLKAVGAALAASVRTTDTVARIGGDEFAVILPMTDRLGAAVVARKVLDAVSSVRV
DFAGRTLSVTATAGLAVVAPTAAFAEEEITRLVQRADVALYAAKRRGGNIFLEDTETLA
>A0A3S4VGY1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MVVNARAEVNPLVRPLDDLLRRRMLLTYFVIVLVMYVLALVQALAIDTPSSDARGEVIAL
VVTAVGLLLALPTPLAGWRYAVALLCVGAAPVTAMLFHERLVAQVWSVVPLMFVAIFVRT
WHTAQATRVAVGVLAGAAVAALLVAPAPVPVMWLALYVLSIVGAAEIFGLSNSALLDAAF
RDPLTLVWNRAGTRRQAGRLLARARRRRHQVAVIVFDIDDFKGVNDRGGHAVGDRVLTDV
ARRWREQIPSSGVIGRIGGDEFVVIVGDCDDGAARELADRMSGNLAVDVTYGAAAGRADR
RAVETLFAAADRDLYTRKRARRT
>A0A7Z7LF86|diguanylate cyclase|EC 2.7.7.65|Mesotoga infera|TrEMBL
MNPFALLMFITTVSCGLLGMYSFYKRELTGARPLGFLMFAIAWWSAMYGLELLSNDLQQM
RLLNRISYPAIVSLPVFVFMFVMAILDRREWFTVKRVILLFIVPTIVDLAMWTNEFHWLF
YRVSEIDTQWPFPVQKLVHGPLFWINIVYTYVLLICSIVLLLREWFYSERAYRTQLGIVL
LGMAFPILVNLNHLFKILPVGYIDLTPVAFFLTALFEALSIFRFRLFDLRPIAKETVISN
LEDGIVVIDKSGTLIDVNPVSVRLLEIDGDKALGLSIDDAFSRIPTLLDFIESTDSRSEL
VIGERIIESRKTSIMSKRGKLRGHIVLLTDITDHKRTEEALRKSQEMYRTLATTDMLTGV
LNRYSLEQLLEGETERSSRYGEPLSVIMFDLDDLKKINDTHGHIVGDNALKAISFQILSK
IRKSDSLGRWGGDEFLIVAPSTDLAGALEMAEKLRAEIDSVEFEAIGKLSISMGVSSLEM
GEKDYDGLLRRADRALYESKKRGKNRVMAI
>A0A8F7U2Z4|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MLNSLFKKLFVLSTTTLMLTLFIIVSFAKVAQEQRVTKADLDQIIDLQLSVDLLRSQLWV
FLQYGDEASLSEVDVAQAELATKLTAYKKNNSQLGNIQRMNQSLNALLNKEKQVYFLSIN
GLDDQGLANINSRGLLHSRYNMIVQNMTEELAYVHQSVLNRNAKSLHQVMIYAAAWLIIC
SVLVSATAWLISFRFKSGAEAMKNAILDLAEGKLDSKVEAVKMDTEFRVMAQFFNQMTLS
LCDTTVTKQELEEEVMRQTQQLKHKQEQLIFLSEHDPLTNLVNRRAFDRALENAIVKANR
TQCKLAIFFIDLDDFKSVNDTFGHEAGDAILVEVANRITAAIRESDFAGRFGGDEFVICL
DLLYDFDIVPKKAEQLLDVINAPIQFNGRTLKVGASIGVSYFPDQTKNKEALLSVADEAM
YRAKKMAGSACFDGKTTVCRKGSKSVRLTSIND
>A0A446C435|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MYVDLLTLYFIIIGTLLATAGLTFWEHRAHPKRSGSLRILSAGFATLALGCTGALFRSVP
PSPFGSAGANLVVLSGYLLVMNGAASLRGKRYRVAPLALLAVMALIWAVAGAQGEDLVWK
YISAFPIALVSAWTTWELLRCGDLKALKPLRIAVAVTGIHALIYAARAFILPWWVAAHGP
GVQLTASTLTMYEGVLYSILLPMTLIKLVREETHLELVRESQTDYLTRLGNRRWFFEQGG
RLVDEAKGRSPVAVLAFDLDQFKSINDRYGHQKGDQVLQCFAETARGMLGPGAILARIGG
EEFAALLSGDAADRAAALGESVARRFAETISNRIDNIGIPATVSIGLVLYELDAPPLADA
LAAADRALYRAKALGGNRLVSAGAALRVAAG
>A0A7G6K4M6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHETPAVAHDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
SLSPEHGSDSATIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
T
>A0A398U0L3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSRAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVICLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1S9JCS0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MAMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEFVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAKVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2T0BDV8|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MLNIWGYKIVECINEGKNNVIYRAIRNSDNIPIIIKKPVSDYPNLSVISTLKHEYEINNI
INSNKIVKIYGRELINNIPILFEEDFGGNSLEKILKSRNFNIIEFLNIANKTTDALKDIH
KCNMVHNDINPSNIIVDLEINTVKITGFALSSMFSKQNQCVVDNSFGGTLSYISPEQTGR
MNCPTDYRSDLYSLGVSFYEIITGVLPFVASDKIGLIHSHLAIRPEPPNELNKLIPRVLS
DIIMKLMKKNTEDRYQSAYGLKHDLERCFNSVKSDGSIEYFKLAQEDISERFKITDELYG
RDNEIEVLLSVFDRASKGEKEIVVVKGHSGVGKSALINEINGLISKKHGRFIWGKFDQFK
HGNAHSPLVKAFKALVEQVLTESKEEIQIWGNKLNKSLGKNGQIIIDIIPEVEKIIGKQP
QIIELPTEETKNRFNLVFENSIKVFCEEKHPLVIFIDDMQWTDATTLKLIENFMGSSPIK
YLVLIMAYRDNEVLENHPLLSTLNNISKQRLEINTIFLQPLTLIDTIEMMAKTFNCEIED
VATLAELSYEKTEGNPLFLKQFLFSLYRENLIIFDNLLRVWKWDLYEIQSSGIANNIVEL
ITYRILGLSSNAQEVLKLASCIGIQFDIKTLSKVFKKSTMETYEILCEALQEDLILVNGD
LFSFILGDEEVNLICDFLHDRIQQSVYSIIDEENKRELHLKIGRIMLAEMISSNKDEKIL
DVMNQLNKGIDLINNYEEKKNIANMELIAGMRAKKATAYQVAYDCFSSGIRLMEEKGWEN
EHALTLSLYVQGAELASLTGDYKTLEKYTEIALEHSETVSEKVTVLEVKILSYTAQNRKI
EAIDTSLLVLKLLGIHFPKNPSLVHVLFQLIKTKIMFLGKGHNDFIELPEMTNATAILAI
NNMVKISTPTFMIYPNLFLLMIFKSLKLCWKYGLPSNSSVFFIAYSMLKCTLGEVKSGYE
FGELALKLINKLDANESSIATFVIYANFIGFRKKPVRELLKILIDSHILGLEMGDLNYAT
AATHIYCYTSYYAGKELSVLANEMSYYTDVMNKYNSKEWLYPHLVFHQTVLNLLGTDDGI
SNLNGSVYNEFEKIPYHIEGKEIGTLWDIYLNKLMLCYIFGEYYEANENALLAKRYIEGA
NATFSIAIFYFYESLALLTKFNKLDFIKQKKLIIKVNLNQKKLKKMAHYAPMNFLNKYNL
VEAEKSRVMNKNLKAMDYYDKAIELATENQYIQEEALANELAAKFYISTGKIKKARTYLE
EANYGYSLWGAVAKTKQLQRDYSYLNITGTYQNHSMKVAITPSENRPVTSSMILDSATII
KATQAISGEIKLEELLKKLVFILLENAGAQKVCYLVKKDANYIIQAEGVINGKNLEMISM
PLDERSSRVPEKIIYSVEHSKKSIILDTAFEDEKYMNDPYIIFKKCKSIMCMPVISKGEP
IGILYLENNLISGAFNSERIEILKIVSSQLAISIENANLYNNLEELVEERTWELKKEISE
RKKVQKQLEQIATHDALTGLANRILFQINLKNLIRTSPIQEDSFYVIFIDLDGFKAINDT
FGHDSGDIVLKVVAERLIKCVKTSDTVSRIGGDEFTIILKDIVLKDDVSLICNRIISEIA
EPISIGENKGYVTASIGVSNYPNDSEDVDELIKKADDAMYVAKRTGKNKFIIL
>A0A2S8DRY6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
IAAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A2N9LJX9|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MQRRLFSSPARIWVAYVVATLAFGVLIVAFVRQQNAAAEAVARTTAEQELHLLRLAVLGD
LERSQYRAAGDLVSAWGESGAQVVELSLVAQSGETIAEFRRATPATDSLQLSAPLEYSYT
GKAVLHLRFDLGPTLAGERRFGAGLVGLYLLAALAAAFLVHLNLERQEALKRLRHATEQL
DSYFNSALDLFCIGDIAGRLRRVNPRWHDVFGYDEAELEGKSILEFVHREDQDETRAILA
CLSDQQAVTGFTNRVQHKDGSYRSIEWVIRPKEGVFFAAARDITEREEREQEIRFLNRIY
STLSETNQLIVRSQDEATLFDNICRIAVEFGGMKLAWIGKEEASTGRIQPVASYGERKEL
LGDVVVSTHADVPEGKGPAGTAYREGEPKYVNDWGTNASLAHWRKTNPLWTWGSSAAVPI
RHNGKPYALLSFYDAVAHTFTGKTVDLLREMALDIEYALVRLELEAHKREADAELRIAAI
AFESREAMIVTDAQANILRVNEAFTKTTGYAQEEVLGKNPRIFKSGRHAAPFYAHMWGQI
IATGRWQGEVWDKRKSGEIYPKWLGISTVYGSDGEVSHYVGSFTDISERKEAAAAISRLA
YYDSLTELPNRQLMMDRLKQALLSSARSGAYGAVLFLDLDRFKTINDTLGHVEGDKLLQE
AARRLRTSVRDEDTVSRFGGDEFVVLLENLEEPRERAAVLAKGIGDKLLEALAQPYRLRR
KEYTCSVSIGVVLWRGGPAADVHELLKRSDMAMYEAKKAGRNSVRFFDPIMQTTIENRAR
LEGRLQQGLELGQFQLHFQQQVNQHGDVLGAEALLRWHDPERGMVPPADFIPLAEESDLI
IAIGHWVLETACRQLRAWSRADATRHLNLAVNISPKQFGREWFVSEVADIIDRTGADPAR
LQLEITEGMLLRNVEDAISKMSQLRKLGVSFALDDFGTGYSSLAYLQRLPINILKIDQSF
VRDLGFDERSEAIARTVIQMGQSLRLDVLAEGVETEQQRDLLGQLGCTKFQGYLFGRPVP
IEVFREELGLVNAS
>A0A212JJS3|diguanylate cyclase|EC 2.7.7.65|uncultured delta proteobacterium|TrEMBL
MKKENKKFVKADADGVRNSIIKKSKSRSTSAVARTDASDSLRVMLDSTPLICAVCDECGR
LIDCNLEMLRVLKVKSKPDATKHFFNFSPKYQYDGMASEEKGMRSVELALQTGFHSFEWE
YLATDNERVPTETSLVRVTWNGGYRILVYSRDVRELQKQKKLTEERTAMMLKTLPLATFM
ISEKCEVIDCNEAAIHLFGANDKHHVLNLFLEDFSPQYQPNGELSSDKARNYMQQAFKEG
CVTFEWMHKMANGGMIPAQVTLIRLQWNENEFVLSAYAQDLRDIKEAEQEMIHRSNYLKT
VTIIAEWLLSSDKKNGEDTVEKSLEFIALNMNLNGAKIWMNTEQNGDMYYALYKSWPAED
AVKWPGSYAYNNLPFWKDSMLDNRVINSFVSDLPRAEQASLDKDKIKSILAVPLLVADNL
WGFICFEDTQKERVFTGLEEQMLRSASSLIVSTIVRNRAVSQMLKNNRELRKKSYLMSSV
NRVAELILGSEKSDFPPVIQRTMKLLGESVGANQASLWTVHYGTDAALYAKRLTAWQHGK
GFIETTHRPELKVYDYIPEWDVPVAGLRDIENSLGGMNAHLRQLSLLNGNETLLLLPLVL
RNTFWGFVAFTYEKNNHHTTEEERSILRSGSMMIAEAITRQEVTAILKIVEEKAATDNLT
GLLTRTAFMQAARALFAESQRNKKPFSVLFMDLDHFKNVNDQHGHAFGDAVLVRFAEIIK
ASTRNNDLCCRYGGEEVVVVLADSDSNAAENVARRIVQDVREAAFESDKNFRFTVSVGMI
SAIPAMGEQVHTYIEKADLALYEAKNNGRNRIEKHAAIHDAHAYHSVGASDRVSSI
>A0A517QGT6|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGAYMNWPLGIAPLLLLAPPTVLAAVSSPRVCYW
TITVISVSSCFAEIFFRPDLEEVRSTYPLSIMSAAVLIGLVMLIDLYMGKLRRKLSQLHQ
QNDELVRQLYETQKQSIADASKSTIAELKEKQTSESKDNTSAESGVNYPLLLLTLQDIGR
RISTNQSNESLIPTVISTAKASLQCESCQIYLWDTKSRTLKNALPARARDQLDYRPAANH
GVAAWVIEHRQIVMRNDADQDYRLKRIIEEDAQMPDAIAPLTVGSELIGLLIIDKIDVES
PTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLYNHATFQEKLHELVKNAEAQS
TNLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPENAVLARYGGEEFIGVLLD
HEYSQARQIAEDLRETLENCPILFEGQQLQVTASFGVTEYRHPATNTKDLVRAADEYLYK
AKEGGRNQVVGLDSNTTRKPGTQAS
>A0A2X2LCJ8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSGNDSNLLIVFYV
QIMPDDLVMQLHRF
>A0A7U6YAZ1|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MKHGFLFGKVILAPVLVLLVLMAVAGGQIVASLDLRSDVRKIDNIQIDMRANIEAIVLIH
EAEVALRLFQANERQNGQNGPPPDIRARLGHEAERILSLAEGFNAPAGGLTDKAQTDREL
LRNYAKLLEQLSHSQSSSVYYEEIEHLHGLLAARLKKNDQALHMALAETSASARLEAEAA
MPAAILLTIIGAMTALAASLAITQSLLNSFGRLAGAMRGLVRGDEKAASADVRLGQEFSE
VSEALDLFRRAILERQTALAALAQSEEGLQNVLDAAPVPLALTRLTEGKVIYANQHCRNL
FKVDGTGEGLDVRQFYANPDDRGRFVEQLRRHGKIIGAEVLMKRADGEDRLMLVSAVTLS
YRGETALVLGYSDITEHQRILAKLQESEERLRLIVETAPVPLVLTKIADDTVLYVNRLAQ
ELFRVPKDSDVLGHPASDYWVDPASREKMKEMLKAEGGRLHNVEARLKRSDGSWFWASMS
ADSTEFKGDAVLLVSVDDITGRKEMEDELRRHATTDTLTGIANRRHFIDVAEREFARAKR
YGHALSIVLLDIDDFKRVNDEHGHLAGDKVVQAVARICKSALREIDHLGRTGDEEFAMLL
PETDGDKAFQAAERIRASIEAALLDLEGLVAHISVTASAGVAAMGGEDKGFDQTLARANQ
ALGRSKLAGRNRVSI
>A0A2P9H8Z0|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MRSLFANSNSTRTESHPAAALCPVGLDAQASSLINEAQTGLLIVQHGVLRYTNAYFAELV
GYSIDELIGSRAIEVVAPEDRPRVEEQVRLRLQGQPGRPYDIGCRRKNGTTFDARVCGRK
IEFDGAPANLVTLYDISEHKQALQMGEWNARMLARTESLSRSGSFEIELPEGKIVATGGL
CGLLGLSAKSLIADRLDACAWIPPEDRVFVSAFWRNAQSDEPFEFQHRIVCADGKHLIVR
HRGVLGLDGDMNRGIAFLQDITAQRDAEHRIQELAYYDEVTGLPNRASLLDEIGFAIQAA
RSDAKGFSILAIDVTRIEEVKDTMGFGASDTLAMTIAARLHGACTGRDLAARLGGGEFAV
LLDPENSGDAEAVIARAQIIRSALQSPATIGTTEVIPQCIIGIAMFPGDGDDARTLLEHA
QTARISNGAGQGSEISFFGPQKSARAMRELGLESALCRALELGELELAYQPEVELRTGEI
VAVEALLRWNSHQFGAVPPAEFIPLAERTDLIVSIGEWVLHQACRQAAASRPGGKPSYGR
RASPSTCRCASLANPISPRASRRLPSIALAIRRGWDWKSRKACSWRIRSTRPRSCTSSRR
>A0A2X1QGA7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLVNKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A1V5R5L1|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MNLLAITRHADLVERLRTAFEGVGHRVLQVSDPLEALAAEAWDRAQLILVDSVGDPMDGF
RFCNLLRGESRALFQGLPLVMVFPEVPAPEDLDRLAEAGADGHLVATDGLQRILTLLGPM
VEGAAGRSLGPRVPIVATGLRAPLASRISSILNHFGFTLETVPPRELRAALGDHRAQIAL
LGLDPAGTRTLELLRDLQHLEPRPYPILLGRLPGEALQRRLLLSGAMDWLHLPLSAPRLL
HACNRGLAWLHARRVQQEFQFQLNDLRERRVLLEMEAAALRNEVLTDPLTGLLNRRAFNQ
NLENAFNQWSRHHRPFVLILGDLDYFKLINDRFGHLVGDEVLKGVAQRIQNSVRRSDLGF
RIGGEEFALLLNEATLPAGLEVAEKLRHRIDASPIVLATGQQVFPTMSFGVAGPEGHSLE
SLFAAADQALYVAKRKGRNRVEAASVPGSGSVSVAG
>A0A2X3ILM0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPIRPSRTLSGEMSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVY
CKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDP
HKDGRIVDANIAALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTH
ILADGSLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREF
HRLVEAPTLSPGVIVCC
>A0A486PD10|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVPIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A1V5UCG9|diguanylate cyclase|EC 2.7.7.65|Candidatus Dependentiae bacterium ADurb.Bin246|TrEMBL
MRNSIIELIKQSASDKVAFETLDSIFKLYEQLQYSSNLNQLASDIFLWLEEEFAIKNMVF
SLFDINKNNKTDILAKGDKFYLDDDLSQFFIINTHTNLNATISFCASSEEHSLFLENKYN
SIEATFFIISTIVQNAILKKNFIDSASLDSVTNVFSSHYFIENLSSYLKLSNNKQNEIFL
LMIGIDRFKAVVDEFNYEIADKVLIELARVIHSNINEFDIVGRLETDTFLVSILSNDDEN
QACEVAKKIISDFSKARVIVNEETRQTLQKTVSIGFEKFVLNSNMSLDDAIKNADIALVE
AKNKGRGEFLKFSKINSSDNFKLF
>A0A377TT82|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHF
KSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFCPIRRSATR
>A0A378F610|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTFPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFYDQYRADAVDRPS
>A0A378F5P1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIAN
LPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAH
DPLTGLLNRREFHHLVEAPTFIPRGYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILE
TSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDG
ETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A377XRY7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAI
NDRFGHPCGDSFLVQVGKRLTAVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQA
LCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEAMYHDKKSRRQENFIHID
>A0A377WTD0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQNGKDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRA
IKHVADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDT
QIPITASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A5E4TYJ9|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MLFVDLDRFKLVNDTWGHALGDELLRRLAKRLVTCVAEGDAVARFGGDEFAVIMRNVQDV
LHVERTAMAILDAASRPMTLSVGPVTVGACVGVAMVACGEVKTPGEMFETADRALYEAKH
GGRGRFVLGDGASVAH
>F8GT13|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MHLDQQTIAVVMMVFFCSTLIIAAGLVFALRASEAGRLWAFGHVLVSAAGLALAISAASG
TGHLGTLGALAFVAGWLLIYRGVRVYYGVPAHPAALAAAGVIVLGLIAATSGMPDGQQVV
LRIVYGLLALVSLATFATLARAGRGRRSIGAPLVLVASLVHLATQLAGFSHAMNLPLAGG
AGAAPLTLFFAGPAGSAWLLAPLIATLLGLFGFTMMAMEQIIAHNESGARVDALTGLLNR
GALEMSALSLVARWQRDGQALSCLVIDIDYFKQVNDTFGHHAGDAVLREVAHALDNSRRA
SDVAGRYGGEEFCVLCPHTDEQQASALANRILRKVRAIELPAGHGHASVSIGMAQLRGGP
GSKEALWRLLFADADRALYHAKEHGRDRYVLASSMVAPAAASASPASMLAPEPDLAG
>A0A378F4J3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGWARTRS
T
>A0A2H5WHT3|diguanylate cyclase|EC 2.7.7.65|bacterium HR13|TrEMBL
MTYDQYLALGFGVLFASFALGFKSSIAKKLSAIFSVSFLLQAVVGFFNQKPISILLLFYS
YLLISVAFFYGLSITRTVRALANKAYTDQLTKVNNRTFLEDILKKELKHYETLGINYCVV
FIDMFNFKKVNDAYGHTVGDRVLAEVGQRLRKSVRSDDFVVRYGGDEFLVVLKDVKEDRI
NSVIERLRENLNFDAEGIQVRANIGYAIYPKDGKSLEELIKVSIGRMYEDKKAMENE
>A0A377TKX2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MMGDQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSEETAWKTAERIRQRVYDLKI
PHMFNESVATNVTISIGLTPLINDNIEQALARADGALYEAKNKGRNIILAS
>A0A5B9PCV9|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MSFNELQAWIIPIAWSLAAVGVGLICGFFAGRTFALSNEPRRLKRDRARTMEALMTVINS
TNQLNSDVTDHNTALQNAESEIQQCESSAQVVDMQDSLVHNIRKIVAANQKMENDLVVSK
FQLEETAQELDRSRKEARTDALCKVANRKAVDETLTFMVSRFRSQKKSFGLMLIDIDHFK
RINDTFGHDAGDEVLISVGKALKECVRPEDFVGRLGGDEFVLMLEGLTEANAELVGKRIR
STIELYNFSVGSRGQSTVVTLSMGLAVIKLSDDAKSLYRRADQALYRSKELGRNQLFTIV
ENSNQPPNPQPASSPVATYEQFKATLDGDL
>A0A8F2J9T8|diguanylate cyclase|EC 2.7.7.65|Eubacterium sp. MSJ-33|TrEMBL
MQDITEKLIKNYTIYHKLIYIFMVLLTVLTRVMNFSDDTPVCVTFASVIFLFGVLDSVFY
HTGVFKNIHVNTVFRMIEIVTYSVFMAFIPYQGVLLVGMFIFLFMLMIEFIIFGSDYDKS
TIVLRKMFLVLPIFVNLCLSLRFRTEKFWFCYVLVLAVIAITVFFVTELLEYSYDAYESY
CTKLMLERNDVQDKNEKLKEYQEKVKTVNERVNYQKIELARVVSDLEQANREIESQTEIM
RYMASSFDINKNINVIVDAIMDVKNPKLCAVYLDESVCNEKHGLSIVKTDYSSMERRLRK
DIQKIYIDFENSRKTTELLTGEELKELRFIGETNIKSLVKLALIDDNKQYGMMIVASDVE
NFFEKGISYYETCLVEYNVSLKTTKLYLQTQDMARKDGLTQIYNRVYFGELFTKAAEKAT
KKQQPLSVALFDIDKFKNINDTYGHLAGDKVIKMVASLDDKYAKENGGIACRYGGEEFLL
VLPGYDEKQALPVLEQMHKEIQSTIVHYNDKEIPVNVCIGLSSYPSICKDTNILVNRADK
SMYYGKKHGRGRLVVDNPDVDEM
>A0A2N9LJ11|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MNLHENANPDARQEVLDALPVLVLLERAGKITLANAEAREALGVTEGKWVERSVEDLFWG
LLPGTAEPQTPLTRTRRGKPFHASLRTSDGKLLPIEGTYSVLNAERREGVIVAHPIGREP
AAPKSQLMEDVLASLPEAVAIEHENHVLYTNPAFTRMFGYTAEEAGGGSLRELIVPETRF
NENAASLKAVEEHGSVTIETVRSNKVGELVDVSLQIAPLLVNGAKVGHVFTFRDIGEHRD
TEKKLQHDAMHDVLTGLPNRALFLDRMNLTLSRRLRNPDYGCGVLYLDLDHFKEVNDELG
HAAGDVLLTGVAGRLRATLRPEDSAARLGGDEFAVLVADILTASDLEIVAARILRELERP
FEVYGRAVHADASIGAAMAGAEHSTPELLLRDADFALYRAKQAGRGRYEIFDKHLEVVVT
SQKERERELRSAVEKRQFAFQYEPIYRLADGKLEGFEAFLRLRRADGSIESLQDLYAMAE
DAGMSILLVRETLEAVCAEQRALSDRLPQQDVTLAINLTRRQLYHPDLITHLMRILATSG
ADPSRLLFEAPESAFNEDPDAAVAVLQRLADWQMRVAVDDFGSSLAPLNYLVQLPVAMVK
LAPRLTAAAVSAGRQTVVLESLVRLGNTLGLQIVAQGIQTQEQLTALAHMGCALGQGPLF
SAALDPDDALDLAEAGYWALPKGA
>D8G0K4|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MLLIVDEDESFTDELVVEANRQGLRTEVVRNLSVAREAFCSSNRNGNSLYPDVVLIDLNL
NDGERGSREGDRQQTFEQGKKESEKINCPTTASCKQHQQRWDSSESESITRLESSYQLLA
DFTNLTPPVPVVVFARHGNFTERVQVARLGGRAFLQKPVLPAQAIEVVLDAIRRSRTAEA
KVMVVDDDPYMLAALRLLLEPWGVKTLTLDDPRQFWETLEVVVPDLLILDIEMPYLTGIE
LCLTVRNDPRWSGVPILFLTAHTDAKTVHQVFAAGGDDYVTKPIVGPELVNRIFNRLERS
QLLRSRAETDALTGVANRRRSTQDLSQFLHLADRHNQSLCFALLDLDCFKQVNDEYGHAM
GDTVLRRLGELLLRTFGGQDVVARWGGEEFVVGMYGMAKRDAIKSIEDVLINWRSEEFVD
TDDRKFRVSFSAGIAEYPSDGNDLQALYRAADEALYRAKAAGRDRVMGV
>A0A5P2ZN99|diguanylate cyclase|EC 2.7.7.65|Rhodobacteraceae bacterium|TrEMBL
MFSACTENNTNIDLTSFVANVPGSDAMTKPSIEADLLARIAQLEAENATLRKAAETDPMT
GLGNRAALARTLTAGAPVALALVDVDDLHGLNSRHGHPVADTCLVEMGRRIRAALLPGEV
AIRLGGDEFAVLTTRDTSAAELAGLHLRLARACRLVTGQDWDGPAAGASIGTGLREPGET
YDEMYRRVDATLYASKRASRSAA
>A0A8G1PYM5|diguanylate cyclase|EC 2.7.7.65|Pantoea ananas|TrEMBL
MIVETLASSDKSPKKWLNACWLGLASFVLTLFCLELIVVSGKISPLWFSTALMTIVVFRS
TSRQLPLLLIACLIGTALANAFIIGPALSNLKFALLNLLQAMLGGLLLRALLDREAPLVS
LNDWIRFVIATGLISPLVGGVLALWILQVGEQASLAFFYTWVISEIIGMLALGPVLLLLT
WPLSQNDLKRASLAETLITLALTLTASYLSLRFLPWPFTFILVVLFWCAVRLPKVEAFVL
FFVNASFMALLLSLGWINVTPTAAITYAVISSWLPFLMVLIPCHIMALVMDAFRHEKRYI
SESETRFRHAMEYSAIGMALVSAEGRWLQVNKSLCDTLGYPEHELTQLTFQQITHPDDLY
DVQGRLEKLLQGEIDAYTLEKRYFRKDGEIVWVRLTVSLVRDQAQQPLYFIAQIVDISEL
KQSEQVNKRLMERITLANEAGGIGVWEWNLTSGEVLWDKRMYALFGMKPYEVPSFDLWVT
LVHPDDRERCVLTIQGAIEKSSSFQMEYRVVREDGQHWIRSQANRLLSEEGRIERILGIS
QDITSLRNLNEALFQEKERMMITLDSIGEAVISTDQDMCVTFMNPVAEKMTGWSQEAAAG
KPVNELLHITHGRHGPEVDNLLLCHVPSEKTAPYLSEEWVLHTPNGEHIDIHYSITPLKS
ESGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAVEHQNQ
HVLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHRLRGSDFLARLGGDEFAVLMPECS
LDQARDVVQDIVRAVGDYCFEWLGRAYQVGASAGITQITAQNCQSSDVLSQADIACYNAK
RSGRGRSKVYEQHALALMGSHHSVDLATLDALQVDLQVWAVAPPGKPHSASVWLVEVQLF
SPEGLLIDEHLLRNNLTDDMLKRRLEDNIVNAFFRQQIATMSQKGIALILPLDVNALFDP
AFVDNLCLRFAESGLARSHSGIALNASSVLSSGDGLIAALIKLRQAGCRIVLQHFGRNLD
AFNQLTGKVVDCLILAPELVANLHNNLMDEMLISIIQSQTSQRNITLLAGPVSVPAVLTT
LTSLDVDGVWGSAVAERQPMSRLAEAPLFTIR
>A0A730C4J2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6B8NDW7|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MLRVFATMCMLLFLTSFASASNKQTLIVTNSKAWKPFSYINEEGEPAGILVDYWNEYGLK
NNQNIEFLLLDWNDSLEAVRSGRADVHSGLLWSETRESFLDYNAPIMSIDTQLYISSRLM
GSDVSLFLRGEHDHLVGVVKGAYEEEFTRLHFPNLNIISFRNNERMIDAAFAGEIDAFVA
DLQVANFYLHTTKGLNKFIGIRHLYSGNLRPAVSEGNLALQNHLSHGLKLISNEDKQRIL
GRWMYINTVYPDYLLPLAILMILLAGVAYIFILRFSVNAKTRELAKANQELRVLSETDPL
TELSNRRHFVEEFQQRLVVPESIAVMIFDIDDFKVINDNFGHEVGDTVIRQVADAVRTVI
KKDHLFGRIGGEEFALVVSGHSLGQVTTIAHKVCHSVRSVVIEDKAISVSLGCAYYPLTS
FNITLSDADHLMYQAKSLGKDRAVIQQIILEELSEQKAVNYE
>A0A2U3KEZ4|diguanylate cyclase|EC 2.7.7.65|Syntrophobacter sp. SbD1|TrEMBL
MESLEILTESVLNIFEEFSIGRRPLNAATLKEAFSARKEIQALLQPVLNASPAERSEEVS
GSDKMQPRIPLPQAATPKNATTADQLSGLRDAFLKILKNLGPLIKGEHEIQLTRLQNKIN
QCDSFLQFGLIGELIGTLVGKIIDDTVGRMDYSNDFLVGLSNDLYKLGDQLLSFQAYNKD
THQLSSKFNDDLLTNAHDMHSIFDTGKSLQDIKIHFASKLFAISNAIQVKNQTDEVRAKE
ADTKIAELQSSLNTYNQEILQIRDRADSLEKEVLLDALTEINNRRAFDLQIRENLRRFHR
NGEQFSLVLIDIDHFKIVNDEYGHKAGDKCLQEIAKVIRTSLRKSDFFGRYGGEELIAIL
HGSNIENALEVAEKLRLRIVRTRFLYQDKVISITISLGVTQVLQTDADPETPFIRADNAV
YQAKSLGRNRVCAI
>A0A0N0Z441|diguanylate cyclase|EC 2.7.7.65|Geobacillus sp. BCO2|TrEMBL
MFKLLESLIQHSTLAFMNAMLREELEKMVVTDYLTKLHTRRYLDERIQQSMGTDASGAFM
LLDIDNFKQINDVYGHQTGDEVLVQVAETMRANIRDSDVAARWGGEELAVYLPNVPLSDA
VAVARRIMEKVREQTIPAVTVSCGISWWGHAGFQDAEQLFKRLTPRFIWRKEKGKNCIFV
HDDGHVYKV
>A0A1C3JNU2|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MPRSFCRYLLTAGLSTGACFVLLSFSSLLWATADSTLQLGDATVKLDDNGLWHPIQLEKG
VDLDEDTLSLLHQSTQPSGTIIGQTGRYLTKLSLSAEQAQSRFVVVGANFLDNGVAYWQP
EGQQPRKIANFATLSPQRLPDMLHAQAFPLTMSEQSSGVLWIIISAQYYPTPITLTLYNA
WDYYQVQGLVGLVTQGSVFVMLTLALLALAIYFRTKLMLTFWFAGYVGLHGIGWAVASGE
INSLLPSLGVNLTYAGMHLFPIAIACAAMFTAGLFNTQEYAPRLYRVFRGVAVCGVVMAV
IMLWLPFIGVFYLAHILALIWVPLSIFTGITMLTRHDFKAKYYLTGNLLYGSSLVYYTAS
HALAGSVLPYPELVVLAALALDCFCILLSLSEWLRVKQKELTEILYQAKVDMLTNVGNRF
AMNEKLSELNGDYWIVFIDFDGMKTINDSLGHKEGDRFLIEAASLMRDQIAEDDSVFRVG
GDEFVWLLEAQDRNMITLKSQLQQLILNIETELKTQWPTSGISYGFSKGNPKKDKKVSLT
EADEAMYQHKQSKHAQVPSVHDSLPS
>A0A7X1BJL5|diguanylate cyclase|EC 2.7.7.65|Citrobacter cronae|TrEMBL
MFPNTMNDENFFQKKVVADEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWLGIMGANL
LPSTALLMITCINLMGAGGMRVFLAGVVLMAVSCLVTLQLTDIPVAVSSSQLSVLLSLPV
LVMYPLLFAWVSYQTIIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>N9L216|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 53.82|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFVFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSPLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A379K414|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSSTTRRGTQRSLQSLLLKRFAMAFATYAMMALVCWFAVFNGLFLGSISTAAWLTLGVFG
SQLVFLWLFLSGRNLRCDDPSLTEAQVLVALAWQPPLLALFDSARGVMMVFYVLILLFGV
FQLPPRVFVRCAAFAFFGFTAMILVEAYRMQLVDPSLAWLQVWVLFILLVWLCLFSSYVQ
AMRKRMHQRRFALQAHQDTLRGMMRQLENLVATDELTGLFNRRHFLRLATRELEHLEHGR
HHGLALIDLDHFKRINDAHGHAAGDRVLQTFAAVARACLRDGDIIARYGGEEFVLLLPNT
DADQFTACCERLREAFARAEPVGVKVDNLSLSAGMTLLVAGDDLDEALQRADQALYKAKR
GGRNRCDASWERAGA
>A0A7W5FMP4|diguanylate cyclase|EC 2.7.7.65|Paenibacillus phyllosphaerae|TrEMBL
MKLQLGVIHGIVGTILMLFTVHMNETILDFRQIAVILSALYGGLLSSVITGVIICLVRWL
VFGTDNYATIIAAVNTIAVAIAVGIACSRRWSYWSKWSVSVLICILFTGAIFVFNLRTDA
LVPVVSYACMMAVGGLLTAHLTAFFIRTKAHSLRMEKEATVDFLTGLNNHRTFDNRYNAL
LDSASLKSECLSVALLDIDHFKKVNDTYGHANGDAVLKQLSLLLQSSARPFDIVSRNGGE
EFSVLFYDTPHEHALLIAERIRSAVSQHIFELNEGQRIRLTISIGVATYPDTKPEALREQ
ADQALYQAKANGRNRVCSNMNLSLGVHSMVTG
>K4INL5|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium asteroides (strain PRL2011)|TrEMBL
MIRIAVVDDDSISCRTMVNYLSRYRKERQEELTVSVFTDGKAFADGYRPVYDILLLDIQM
TPMDGIEVARRVRARDESVVIVFITSAPQYAINGYEVGALSYLLKPLPWFAFSQELDRSI
AQVRGRVDLSILITEGARSTRIPLKDIVFIESVRHSSVIHTLDSSLTTNSTLKSLEGQLD
QRGFFRSNSCYLVNLAHVTGMEDQDCIMSTGQRLRVSRPRKKSFMTALTAYVAGRP
>A0A379KBN5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MAAVMDDQGNAVSELEELTLALLHSRAEVERLGEREQLFSSLLGSVNAVLWAFDWNEQRM
IYVSPAYERIFGRSAALLLADYGEWRNSIYPDDIDYAAESLAKVLEAGAVESREYRIIRA
DGQLRWLSDKCFVSPRMGSAEQGCVIVGIAEDITEKKRLEGELHRLATTDVLTQSSNRRH
FFECARSEFEQARQFGSSLAFLLLDLDDFKKINDQYGHQVGDQVLQRLAQCGSHALRRGD
LFGRIGGEEFAALFPGCEQDVALQIAERLQREVQRLGFQHEGRHFGITVSQGLTVMRATD
ASLDALYARADAAMYTAKRQGKNRIVLG
>A0A517YSA3|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MNQTLLDQVIESPRLPSLPSIALEVIDLVQQPDVDIAQIADTIQNDPALSSKILKTVNSS
FYGQAYTVSTISHALVVLGLNSVKTLALGFSLVSNLQNSGGDGFDHIQYWKRSIYAASAA
KEFAKQQRLVQQEEAFLGALLQDLGVLALNQVLGDQYTDLLNQTDGCHRKLIELETSQLK
MNHAQVGAELANAWKLPPLLIAPIRYHESPDEAQPELQSFVRCVSIGSVVADLFINEADG
ESLERYYDLASEWFGLCQEQSEPLLHEIHKQTKELQRLFDLPASDYGNVDDILAKANEAL
MNITLQTQKQQHELTQHANELREQNEHLVNQANTDSLTGVANRRRFNEYIADAFECTKQN
AAGHLSVLFLDTDHFKQFNDTYGHPVGDRVLVALSQTLQNIVGDRGLVSRYGGEEFAIVL
PNTDRRTAALIAEQLRSEIEKTIVQSDEGKDLHITASIGVATYEGMFFDRVEILVKAADQ
GVYAAKNSGRNCVRIFAPKNQPVAA
>A0A655WPJ8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLDLNGFKQINDTYGHQMGDAVLKQVAYRLNNSIPSFDYRVFRMGGDEFAIILSSINSTE
QMMMQRMIKQCFDHEFELSGDLRAKLNTSVGVSTYPLDSTNLSQLIHLADKNMYEMKFLQ
KSPSXXXXXXXXKVYHRL
>A0A655YIK7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTGAYNRQVFEELVDDAISLANKESHPLSLAVIDLDHFKQVNDNYGHPAGDLVLQRVVAL
CQRHIAQVGTLCRWGGEEFVVLLPHMTQQEAYQRMESIRAEIAMHASQPQVTVSIGVVQY
QQNESLLHLFNRADQAMYTAKSEGRNKVVGL
>A0A517YRH7|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MNSRAIRFPKHRAATPNTMSSVEPRSNNEPAKPPRDLFDLFSRLISTSPDFISYIDRKIT
YQIINDRYVTATGLPKEQIIGKHVKDVIGSEIYFTHTEAALERCFNGNTTTYEGWFNYNA
IGRRYVTTKLTPYFDKQNNIIGALIYSRDITDQKKAEDRSIESEAMFRQMFEGHKSPIIL
IDLQNGHVADANHQACSFFNTNYNQITSQHANHIAQPINSSRGLFDMLLSGQADHEQLII
KLNNKTQKEVLIQSTPIWVDADAHLCIIIRDITAEAEHKRELQSIFSNSMIGVGIMRPGR
TIDKCNPRLAQMLGYDHPSDIEKHSTKILHYDYPETERFVHTYRTKLINGEPIHADLQLK
RKDGSPVWCSFSANALDTNIPPDLDKGILWIVDDISPRKAIESMLQKIASKDGLTGIYSR
SYFLEHSKKMIHQTQSDNTPLTLILLDIDHFKRVNDTHGHPTGDKTITSLTQCINKILRK
SDAFGRMGGEEFAILLPNTSLDETRTISEQIRQAIQNTTIDNDNTSFNITISLGFAALTP
ELDTLDKLISAADKALYHAKQSGRNQSCSYHDFCLV
>A0A7W2V5F4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-01064|TrEMBL
MNKDFASTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGSTMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVLNAHQKRFAYWSWDPEDNTDTLGALVS
RWLFPVPVAQPIVHNGTVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVTEMQNITDVVHDVRANRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRASFRNSIAALMNDSSAKANSALLFLDGDNFKFINDTWGHAA
GDGVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSEREVQHICAALSQQFIRPFDL
HNGQTASLSLSIGFALAWENASVEALLEQADRNMYLVKNQRTKTIT
>A0A200L6M4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINLLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A200L495|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSRKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>A0A8B3KKZ1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLSALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7Z1CZH2|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGVNRCISPEVFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERA
>A0A8G1LZ62|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MDSLVLGRTLLQQGQSHQALQHFLDGLAHAQSEQSNEAGYWLAIADIVHDSGQFERALSL
HQHALSLAEGEAHYCSAYLGLAADLWAMGQVAAAYPLQAQALAMAVLQDDAVLLVQSARL
YQLQQQWPAALAQFEQAVLLVDDCESFMLHWSILSLYLQINQTDGLPAAISRASSALAHA
GASDLRGALLIKLAQASQACQQYTAAVDFYQAAMLHSAQQKKPPRPRRLREVEFKLQQTT
SEIEIDLLRLKSAQQDEQVRLLESTTYRDAVTGLHNLRYLEARWPMLLALAIDHPSLCVL
HCGVDQSTYLREVMGEAKSNDCSLRIAKVLQDALPEGAELIAGGQLVFKLMLPASSADLA
NALIEQIQQQIAQLDFSDLPEALTLSMGGTIYQQGDTVDVLQLRADLALYLAMRHGAGAV
VWEMAV
>A0A8G1GWJ6|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MMSTSTDRFSVLARLMISFGALAMLTGLIGGVGIWAFARMTTTFQTVATQDVPALLKLEQ
AQSEMHQVILAERSLLFMQTATPTAQETLKKHAEHLAQLDVLWQQYITLNKAKIAPPPAF
EKALAAWANASRDVLKILSEDTPAARRDAVDLSLSDAAEKYNQVLNALRQMTQQQVLSLS
ERVKQEHLMANQMEKMIFIFVVGTFGLAGGLAIWLARWVGGPLRQIMVAARTQELNKANA
LLFDQSNTDSLTQLKNRRFLETTMQGMSASTLKAHRANQHKNQPDQHANQDLALLMIDVD
HFKRVNDEFGHHAGDLVLQQIAQILQKAARDSDTVVRWGGEEFLIVASNVSRHKFPILVE
RIRADVENHHFNIDAAQPIRLTCSVGFAFFPWIAQHPEACSWEYAASLADYCLYLAKNNG
RNTWAGICPASDFKPEERPINLASDIPPLIEQRRLIVLLRQQSPDDSQAVKSTANERHEA
APINAISPSPS
>A0A1X3JHH5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H386|TrEMBL
MEMYFKRIKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGVRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0M2WWK6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MDSLLKHMVDMTGHRDHTMLDISVISAVQELAAASQTRVLALTTVRGQVFVRSRAIIVAG
SVARMEEHNDPTLPGEPLSDYPALAACIKRHEASADTLCADGRHLLWLPIWIGDQVTTCL
EITNPTPYTGATIQVIGGIVSVYRNFQNLLDYSERDSLTGLLNRKTFDDQLAKILHSRGE
PEAEKPRPIDEERRHHTDTERQWLAVIDVDHFKLVNDKFGHLYGDEVLILIANQLQSSFR
SQDRIFRFGGEEFVVLLRSITLDNAQKIIDRFRTNVEAHDFPQVGRVTVSVGFVSINAYE
APVIILGRADQALYYAKSHGRNLACHYDELVAKGLLTTITSNDTAEFF
>A0A447LKD1|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MINEQTFSKWRLWEIPEREKPMNSDDKYRSGLHFARRIWLPRTVGHFCCFIMFSGVLVAQ
SLSGWWWLALVFYAFVWPHLALQIAERSSDPMAAERRNLIIDTLMAGLGIAIMGGNALPC
LLLFMMVNMNNIGAFGGRFFATGFMLQLITALLAVQFINAPVNVVTTPLQFYLSLPTLII
YPALFGFVCYRNACDLAEHKRQLELISTRDGMTGVYNRRHWEQLLSIEYENALRYHRAST
LLLIDIDHFKQINDTYGHDVGDKAIIAVTQYLQLTLRVSDIIGRFGGDEFAVIMSGTSPE
SAVAAMARVHERLENLSLDDSASLNVQISVGIAPFSVHMKDYQAWLKAADLALYKAKRAG
RNRTEVYDAR
>A0A447LM60|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MSDFILSRISETLASENSLEGLVRKLLETLEIVTEMDSTYLTKVEVEQGKQLILFSRNSK
EMQIPEGMSVPWGDTLCKRAMDEGCLYTNDVAGRWGDSAAAKALGVRTYVSTPVQLDDGT
LYGTLCAASSDKKDLSVRAEYVLRLFAGLIAQYVQKDSLLEQLREANAALIAHSYTDPLT
NLPNRRAIFKNLDALFSIARHMKRTVIIAFIDLDDFKEINDLHGHETGDLFLIQVSDRLS
AGVSKDDIIGRLGGDEFLVAELGGAVDAPQEKNASRLKARLNGLLTGKYLLRDVALNYGG
ASIGIYVAQPAQEDPDSALRKADADMYIDKNARRQR
>A0A8G0E9I1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Minnesota|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6S7AP18|diguanylate cyclase|EC 2.7.7.65|Achromobacter kerstersii|TrEMBL
MDPILAGLSRSLPQAKTVEQLTRPLLDMLGSVTGLESTYLTSIDLAADLQHVRFARNAGD
MQIPEGLSVPWSDTLCKRALEEGRLCTSDVANCWPDSEAARQLGIQTYVSAPVRTDEGTL
LGTLCAASAQQHQIPPQAEVVLKLFSNVIANFLEREILMEQLQAANVQLLSYALTDPLTG
LPNRRALYEELERLEKRALREGGSVLVGVIDLDGFKGINDTYGHQQGDVFLQEISRRLAS
TLRTSDMLGRIGGDEFVLIGPGPAIERGNIGPGGEAQRGEAEDAARALEERATAATIGRY
QLGDAVVPYEGASVGVVAVDPRGLDAESAVRLADARMYEIKRARKGARTIH
>A0A266ZP90|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fragi|TrEMBL
MDNKRGKGLSFAKRIYAPRVIGSGFGSIGLMAALYPLDRSIWVWPLLLLNAFVWPHLAYQ
LSSRATYPYRAERRNILIDSMCGGFWAAAIEFNPLPTVIIVSMMTMHNVAAGGPKLLVRG
ALAQLAGALVALLLFGFAFTPHTTSLQVYACVPVLILYPFAVGMVSYGLAITLAEHKRTL
STLSRTDSLTGLLNHGSWKDLLQLSFQQSLERNSPATLALIDIDHFKQINDTYGHIVGDS
VLRQLSKELKDNLRTEDLAGRYGGDEFCVILPNRTLDQAREIMERLRHVIDNYQHADEPG
LCVSLSIGLATCRPELLQASTWLNEADKALYIAKNTGRNKISVGAADTLAESQLSNDPV
>A0A653KLL7|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MPEKRIHIVTRSQHWLLGTLVMLLLALTFHQTLKQVTELNERDTHNMASRLGSQFQQMET
VLEAMRGQAEERLRSNPQSALTRQLYQALRVDPELGFSLDKVPANLPAGLSGNLTGLGRL
PAPGSEREARLHLALSLSPLLFTASKLLGDKVAWLYFTGVDDFIYLYPWIPSSKFRFHRA
IYLKSYWQDALKQQNPSQRAIVSRPYEDFAGKGQMISLSQPIVKDQTLVGVISIDVLLTR
LDRLLHEFPPEIGDLFLVNQDLQRLASSAQGADFVPKFQTDRHGYQWQQGALQLVQAIPD
TQLSLIHHIPLTALTQALFWHSLPSLITILFMMWAALSSLKARRLNRQLDYLSSHDALTG
AYNRHYFDEFERLHLRAKARDVGVVMFDCDHFKQVNDRFGHEVGDQVLIRLVTLCQPLLK
KEDALIRWGGEEFLLLARGREPLEQLAERLRLQIAEHPWEEIAPDLAVTISLGYHHCRAG
TPLKEAIHRADLALYQAKANGRNRSEGWQDDGAKNTG
>A0A4V6N2F7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrestris|TrEMBL
MNTEGIAVLAAQWKSVCQDFSTTDLNNTFQFIQTHSQTLVYEFYKNMMQEKEASYFLSDD
IVQSRLKATLNQWLIDCFQVPLHQNFEPIVQKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFVLQAEQEQENSLRMISYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAA
QKDKQRSSLLNWENELMFKVFSHELKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVKAIVD
RIYQIDTLSQQVLNIAEKDESIQLIQDIREKNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNVPLSLLAIDADHFKRINDKFGHAAGDSALQFIGEVLLDCI
KGSDYAFRVGGEEFLLLLVDSDLIRAQEIAEQIRSRIQETTIGTRPGSSFNFTVSIGCAL
YDGHPDYQRFIDAADTALYAAKNSGRNRVYLAKNELRNSNIDSTVHS
>A0A5Z6YTF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kintambo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1Y6MP72|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MTDISAIVNEVGVLKQRLDLAQLSYRDSNLKSRREIVILKRLITRLAVACRGIDNELDTS
LQAISLDLEQPLEISRLIPRLSIVERLVIQQADVIQLQNKRLQHHISQRGRTLSHYQGLP
QSLQRDLRGIFNQPSTTLLDNHQRILRLLELYERSIKLIAANNNGTTLSADQQPSFEVEL
AAELLLVISEIDFTNEQGEQLFVIREQLTQGVNQTRLQTLLLQVLRLIVAGTHAERHASQ
QFLNTLNSDLASLQKNTAKAASSFAVLHQHRCDFNTSIATIATTINQQLSLKKTPAATPL
LVNLANELQQLAQRNSQLELREQALIEQLNHNDNKVHQVQQQTHSYHQRLSQQEQNIFRD
KLTLTYNRSAFDDRLKHEYQRWLRYQTPLLLMLIDIDDLSQLNQDYGHNAGDKALKIIAK
TISQQLNPTDFIARFNDDAFMLIITDCNDQQRHQTIKNIRAAVSQLPLHFKGQSVAMSVS
ISSSFFANNDTPKQVIERAETALLHAQHPRCNIIIDQI
>A0A173U0D4|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MDRYFFILTTIDLFVLGFMCFLTKLSESLNKKQKRGFFLAYALIACISVLEVITIVVDGT
PPGYRWLNILSNYLGFGLTPAVALCLVYVLDKKTIIRRGFKAAVCCEGAYLLFLAATLPY
GPVFSVSAENLYARGGYFFIYVIMYYASMLYLMVATVRTAAVFQNRSRTLIYPLTLFLGA
ETVIQIALPALHVTWLCVTLLSVLYYIYCSEMWNQLDALTGLLNQNSYLNRTIEMRRSGG
VLVVFDVDDFKQINDRYGHLQGDVCLAEIADCIKKAYARCGYCYRIGGDEFCVLLKDEAS
EARCAATLQSLLAERRKTLTILPTVSLGSAAFSGEDVVAVKDRADRALYCAKKEQKARAA
AAKPADSGEKN
>A0A087DBZ1|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium saguini DSM 23967|TrEMBL
MAVIFIVDDDQAIGEMLSLVLENEGFQTVTCMDGLRAVEMFPTVKPDLILLDVMLPGLDG
TEVARRIRETSNVPIIMLTAKSDTTDVVAGLEAGADDYVPKPFKVAELLARIRARFRIAR
PVAVEESGSSAKDATVNHIERGGIVIDRLEHTATKDGKDLGLTPMEFELLFVLAKAAGEA
ISRSTLLHDVWGMRAPAIPVW
>A0A517XKS1|diguanylate cyclase|EC 2.7.7.65|Gimesia maris|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGSYMNWPLGVAPLLLLAPPTVLAAVSSPRICYW
TITAISVGSCFAETYFRTDSVNGKNSYILSILSAAVLIGLVLLIDLYIGKLRRKLSQIHQ
QNDDLVRQLYESQKESFTHQQKTVDADETKNRQLAESRDTSTGEVGVNYPLLLLTLQDIG
RRISTNQSNESLIPTVISTAKASLQCEYCQVYLWDSKSRSLKNALPARARDQLNYRPVPN
SGVAAWVIEHRQIVMRNDAEQDYRLKRILDEDPNMPDAIAPLTVGSDLIGLMVIDKVDVE
SPTIGRLLYILSNIYALGIKNSQLFKRIEEMASRDGLTGLFNHATFQEKLHELVTQADAQ
SSQLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPEKAIIARYGGEEFIGVLL
DHEYSQAMQIAEDLRETLVNCPILFEGQQLQVTASFGVTEFKYPATTTNELVRIADENLY
KAKESGRNQVVGLDPNSTRKPSI
>G8S277|diguanylate cyclase|EC 2.7.7.65|Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)|TrEMBL
MTLQPHPSRFGLLPLADRIRWSTSLRLGLAAMVAAFWIFLPGQRRTDGKDLFAVALLCAW
ATVLTVAAPRVGRRMAIVAVNIALLVDGLGLATALHAYGGVSGPISVLMVLHVCGVSLLT
SFRSGGKVAVWHALLVLCVLQAEQVGLLTVKQPAPLPMAGYVTFVALLGAAALATSLYAA
LNERELRRRRYDAEVLRSLAVHLEASNDLGEIAAALTRLAVEDLLAVRALVVIEPASDEE
GRGLRFVEKGWPPLPAALDTGKTAHAHGSLLADTEAGPVLVRNLDKQRDSYVVSRLPGAE
RLAVLPIPLGPAGRGHLVLDMGRSKRVEHRMMSTLIQATAHVGLALTRAGLVERLRLAAE
TDGLTGVANRKFFDAALAQHIDHAMRTGEPLAVTLVDLDFFKKVNDTYGHQTGDEVLKAA
AAALRSTAREGDVVARYGGEEFAVILPGVPVDDVWQTAERFRNAVRTCPAPVPVTCSMGI
ASLPPGGVPPTVLLEAADQALYRAKEAGRNRVEIGHFTDESLGTAVGRGH
>A0A0H2UYV5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A658YYR9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVESINLSTSIGVAHSNKCTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A7Z8GHX0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3T2V165|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGSYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A852Q6U2|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MDKPLWPKKFHRLFNPGRVVNICFIVVLFFSTLLIWREIRVLEEAYVANQRNNLENVAHE
MDGLLQFNLNRLLFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTLTV
YGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNNNRIFSERMSYVSRSGFYTTT
DAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPLDY
EHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTPLSPKEQ
EQLRYALTNDNHGGIRQLTRYISWEKIRNFDGVLLHIHTLKEGVRGDFGTISIALTLMWL
MFTLMLIVSWGVIRRMVINMSVLQASLEWQAWHDALTRLLNRGALFERAIAAARSCRRNN
QPISVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREQDIAGRVGGEEFCIVLPN
TQLSQARAIAERIRLRIHSREILLHNSVSLRISASLGISSSETSDEFNFEELQSIADHRL
YLAKQNGRNRVCSAG
>A0A0H2UZB1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8G0BUE7|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNPELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A7Z8GJ90|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTSALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A658YWC3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A852QSU2|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNDESKKYISVIFKEWLPLYDSLTPAVKEVLKNIAEEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLALWVKEILTSDKAQLPALAERQYQIGSIHARIGIPAEAVLRGARQIK
AGLIEYIRSHVNDRRIAVDAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPMEYGKQQAALSGWENTAIFNIVSENKANTNATLLSESEFGLWFRHKCVRYFNKNSQM
DEIAALISQVDDLLIGWRASDSVMDYKNTQNLIQGIHIHCQQIGSQLGVIFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIIDIDHFKGINDNWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGVSEAFTILDRLRKKISQLAFNVGGDTQIPI
TASIGYAVHSGHPDYNLLLRDADNALYAAKREGRNCVKMHKGRV
>A0A7U9BDU9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA271|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7Z1IY20|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3S4DT86|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MSSLSIRSFTLFREDQPVRDALVLFTLTILLHFMGAMLLLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAICFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVILAQLVLWDKRRADS
MPGPINALNLFCYCLLAALVCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSVLGRFRFSQLLPVIALVLSMALGVAVGGAGSLTFPLPALIWCAIRYPLPLTCLL
TFITGITEILLVANSLIHLSPDARPQPWQLFSTRLGMAAMLISPVIVATSVEAINNLVKQ
LALRADFDFQTRVYSRSGLGEALKRQAPHPDKQLSVMVLDIDGFKRVNDTWGHECGDCVL
AQFAQRVRELAGEEGMVARIGGEEFAVAALLDNAQQSHLLAEKIRQGIESETFTWGQQRI
RLTVSLGLQCREVGEGRIAELFNQLLMEADDLLVNAKQAGRNRVCVQALPDGV
>A0A3S4J5P6|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A381CCX1|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MDINHSTGESVITSTKGYMWFLSLNIIFCAWLLLRGTHRSDVEDLPLMLQILCGCIITLS
LINLLITVKLKKNINDGFYHKLLPFVVLAFGLLWSVLFLNFTLYYQNPLITLMLTVTVLL
PATITFYISGRLLLIFSAPLVICLLYVEFFLQDKFSVAQVVGAVIMLMVIYSARYILLEW
YQRVQRSEYEKNILIKKLVQQAHYDALTGLFNRLSMTSFFEECVSALAGNKKKLFMIVMD
IDFFKQYNDMYGHVAGDKCLIKVSQCIEKSLRKDSDSAFRFGGEEFVVLTVCDDISQVKA
ISHRIQQNIAHAHIPHKGSRISSVLTISQGIAQWQEGMTLEALVEKADQQLYKAKEQGRN
RVNY
>A0A3S4FZ16|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNLAVRNNSPLSCLMIDIDHFKAVNDNYGHEAGDLVIKNVAAIIQRAVRDLGMAFRYGGE
EFLVLLSGSDEASAEACATEIYNNVRSMTLRCGLTDIGQVNVSIGIASYPQHAQSDSLLR
AADAALYRAKELGRSRIIRFDMLKSA
>A0A3S4JE43|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MVYKSGTINDSWLYTTESSLLRTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINR
NFTHNLAINYTETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSV
SSISLADTEGHYLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPT
ITIFKPIITPEGKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGAL
FKPFVRDELMDKMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNL
VIGGFTLAAIIIILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRE
LSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIV
LRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGL
TVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A3S4JKS0|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MQVGKRLTAVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRID
YEGASFGVVTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A839V9Y6|diguanylate cyclase|EC 2.7.7.65|Halomonas cerina|TrEMBL
MTDRYPWPARLFTLMSATGALLLLGQALWFYLMGDYARILLPSLLAMVMVVAALLGIGRQ
NISRTASYLVLICGYLMIAVELPRQSGNPALWIGLPPVLTLLLLPLGSAMLLNLALTPVW
LALLGNGQLDRDITLSYLTLVTVAALVPWEHLRQHALLQATDPRDPECPAVTRSALHDRL
AGEFERAALLGQPLAVLLIDLPQVEMAGEQFGQRTRQALLETFCRAVTSRSRQQDLLGRE
NSEVFWLVLPDTTESSALLVRQRLEQALLRDRLLDIGRIEMHSRLCLPRPRETWPHFEQR
LQAASQALLDT
>A0A0M2HA23|diguanylate cyclase|EC 2.7.7.65|Microbacterium trichothecenolyticum|TrEMBL
MLGLAICGLISVDGQSTILDANTQVLSWLNCDREDVIGRPLEALLTLRMPLEGADGQRPT
DATLHGVSGVVRPVVVGSLGEDESGVERIAVYDVSTRSAFSLGFQGAEAKTERGRQRLQI
LLNAAVGFGNVRTEVDAAELLVDVAQRAFAASAVSVHIGGPEGLIQVAGVNPLAAHWPTG
LRPAGTTTFLGGQVLIVRSPEHADSYVPGVGMSDIYRAGGVHAAIASPMRSHGDAVGAMV
CFFDHPREFDEEAVPLAEALSNQAAQAIARIRLEDTLRRAAMHDEVTGLPNRRLIEEDVT
RTLFQDYSALTVIFIDLDGFKAVNDLLGHAAGDALLREIGQRLRGVIRESDVLGRFGGDE
FIAVAAVDSVGDAAALADRIRAAIAEPYDELPPVLSITASVGVVTVGNDGAPVMDQLIRA
ADHAMYEAKMAGGDRVAVARIASSPVLQ
>A0A4R8R8D1|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MNTTYPGRADADGEQCGRGRRIYQANNELLEQVRLHRPVSLVTAIVISTIGASAILMASE
GLSIIPALCICIALPAFGWGIRYSLKKQVSYAESIAYVAYCDIAILVGICVVTTSGAAFV
KLAWLLAANTYVSVLHGRVAVVVQTLVTALGTVLAVSGAVVRHDVSATVLTSVVFTMLLA
NVIAGWLIYLGKAQFTEHAVGRDHLSRHDDLTGLLNRRGLQEAYAARVGVPGMQVVVAVV
DLNSFKSVNDTFGHHVGDEVLQRAADRLRAVAGPDALLARLGGDEFGIVALTDSPRDIDY
RTAVSEALGGEEPLPVTASVGVASTVLPESDRTVTHSLASVVPYLLVEADGAMYHAKKDT
GIEQCPPR
>A0A5W7Q0H4|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPMPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C3J977|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MRSYSGFKNQRFKTYFDNEIYLPYINFIYIPISIFCAFIVTDYIHFGSECITPIIFRVIL
FLLMMAAARYCITNKPNVLELVESAFLVISSLFLVYVGRLAIELNNFDYQGGIILVMIYI
GTFSRLSARYSISTLSFIFLAYLIGLAPLLYEVEPEHEIETISVYISAYILISAACIRRD
LEVHKRFAQSEQLRKQAIQLRKQSNMFEALSYQDALTGCYNRLYLHQVIEPSIDRQRSIT
SIMIDIDHFKSINDTYGHQMGDMVIKELADEIQKRLPTSSNCFRYGGEEFLVLVQGETEA
SIESLVNALLESPTRLRLEVTISIGVKHAPQALGSVEQLIDDADQALYISKKGGRNKITW
CD
>A0A0T9TV84|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSRSMISTKIFRLDLGRLILILAVMSAFVTLANSFYASYKVQRQLLIDNTLEANRVYATK
LASSTEIFLKSAQKQLYYSSMIAAQHFDDPIILQAETARLKYQTDSFNSVVITDAHGVIR
ATSPDSLQLLGHVLTSPGSTEALKLRRPLISKPYVSAANNLVVNISTPIITPDGRYRGYI
GGTIYLRKQSALNELLGEHYYRDGSYIVVLDSDRRILYHRDASRVGEILPPKPLTEVVKN
ATNGSLMVISSGGESMLAGYAVVEPSGWEVITLRPEASTLKPLEGLMIKGLGHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIAMSIKEIPSWYFESTQLKRALLIGISLLQ
KKIGKLKFEAQTDPMTGLYNRRGLATTLEPIAQLGQSFSVIALDIDHFKLINDTYGHDVG
DEVIKRLATQIRDSSRDTDILCRSGGEEFLMLLPGTTLDVAIQVANRLRHNVEMMEIANI
LPITISLGVAYWSGEGMPEDALKLADEALYRAKQRGRNRVEIG
>A0A7T9XV43|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MDLSAAEKPAPDNKTLLHITIISIVVFLLALFCIRLSEQSENLAPLWFPTAVLMVALFHH
PMRYWSWQLLAAGICIVAANYILYGISWFPLPLTLINLTEAAAGAWLLRKFLQPKDPLNN
LFSWLKFSICTVVIVPLISGLAAAWYLAPQNGSFTQVLTVWFMSEAIGMLALGPVGLLYR
RGYFNITNKTKALFDMTWMMIVSLSACYLGLMYLPFPFTFIIMALIWASIRLPRFETFTI
CFLATLLIAMMINFNLFTLHVDTKLSVQAFSFIPLLMVLIPPHAMAMVMHAFRMEKEHIV
ESENRFRNAMEYSAIGMALVSPEGKWMQVNQALCKLLGYRQEILLTLTFQQITHPEDLSA
DLKLLDDLYHGHIPSYSMEKRYIRSDGEVVWALLVVSVVRDHEQQPLYYISQVEDINDLK
KSEIVNRRLMERITLANEAGGIGIWELDIRKQLISWDKRMYELYHVPLNTPVDERVWQQY
IHPEDINRVKREYSAALTQRQPYRLDFRLLLPNGDIVHLRNQANMICDKNGNILRLIGTT
LDMTEIRNLTEALHEEKERLHITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALG
QPIQHIIKLTNGVDGPEIDNPIEHCLTHRPHSSLNESIVLHHRDGQYYDIQESVAPLKTL
EGTVVGAVLVFQDVGESRAMMRKLSHSASHDNLTGLPNRANFENKLKAAIQKSIDFDQQH
ALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHLRNSDCVARLGGDEFGLLMLNCTL
PHAEAITQSLVSMINGYHFYWEDKLYRIGASAGVTQISSSNSQRSEIMAQADIACYTAKH
SGRGQVYLYQPRQKQLLARQHELLSREDVESILSENQLLLQVTPTAPPKTPLSVCFYQVS
FEIDRPQSPLVSQSAFEEAATLYNLLPKVDSWICEQLLVDHAQAIHQKGLALAIPLSQAS
LASWANIHPDNHGNCPFLDEQQLCQIHKHAGANALSNSCATYPRVEHIYKNQKIKSMSLS
CPEVTRKVLFSPEALILRFSTIHQYDYYKAPDIVIDERIANRACAAIIAASEEISVPGET
ISIEESLWAINRFLLTNQMSSDVNKNKMAEMDSLRAKLISAVASGKAADELMAIDYSPAI
RHELFDYFYHFLAQTPDIRGKKVLAGYADTLQAVLTDTLISPKHIEQQLSDAWHQHALPF
FMQHSSIWRNYFFYRIHHDQLAMGDKCAVTVFNLQVIDFFYLKTLISAHVMKTGQLVEDD
LIDIVYSYHACCDTSDDLGQQLTQELTACAATDDFPLLSLLI
>A0A8F9G4G2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MQRPSLERVLRRTYVRLAFSAVSLAAVCLVLVSWTVLRAYANDNLMLLARSISYTVEAAV
VFNDAPAAEDAIAQIAGNEDIAQVRVVDNHGATFVFWERTGDGPLSRSVHRIADLALPGG
AVVPVMHNGKVLAKIRVRGRGHQFAIFLVGGIGGVLACLLIILGAGTFIARQMHRDIVEP
LRALAEVAHAVRRDRAFDRRVAATPIMELQELGNDFNALLDEFEGWQHSLREQNATLSHR
ANHDPLTGLPNRTHFVARLEQTIRDARALDTAVGVLYIDSDRFKEINDTLGHDAGDAVLV
TIASRLRETLRKDDVVARLGGDEFAALLPGLEDEDDAIGIAQALSESMLEPITLPGGHQV
TTSVSIGIAMFPSHAHDVASLLRTADSAMYEAKRTGERAWQMAR
>A0A128EXN3|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MKILNRRVHIRVATGVAAGALIFSIFASITWFYISYHQEVDRSRSQIKQVITTIEQTASI
AMYLGNKELAEEVLRGLEANDIISAARLTSQDGLSASFSGSSDLEQTDTAIIFPILSPFN
ENEFVGDLLVYPNQKFIENTAISLAKIQVIVLVFYSVITALLTLIIVNRILTEPMKKIAN
RFHLITPGDTTRIDVPVGHKENEIGALVSDINGLLDAVNNQIDNERDLRSETENLSKKFR
FIFERASAGIGLIDSSNRLIVANPALLRLLGQTFIVDTDRFSKTDFTGYFNDPAEIKEFI
DEFWLKPGNQFSAVDIQLKHKVRAADRWVHCLFSKVEDINNPDDSLLEVVLYDITERAER
EQNIIYESEHDPITQLLNRRAGMAKLEVSLQEADKKQRKFAVLMIDLDGFKHVNDTYGHD
AGDKVIIEVAKRIKQFFRGSDVVARWGGDEFLIGFSYNPNYETAVSDIASDLQFQVALPV
EIGHEQTATVGSSIGISVYQNNDEKISALIEQADEAMYYVKNNGKNFFRFYQAEETTASA
NR
>A0A6N3E1D9|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MKFLIKKYGTSIKINIFDKIIILLTVICFCATLTFSFISYYSSLKNNVEYIENNLEEFSE
NTKLLIEEYVDKNFKILEYIAGFEEIYKMDWQEQYEFLISKTKNLDFNHYIIMDILGQGH
YTNTGEIKNQINEEFYRDIIFNEEFISEPFLQVNENRSITTLSVSIYDEENEKIGALCGV
IDLSKINKLFEDKTIGKEGYCFLINREGYYVSHTNMEYVHKRKNIFNDGMINEDNNIEFL
KYVTNINKPLLGNVTLNNNVYYTSINPIENADWYVVYLFPKSEVMKNLNKFISSQIMVVI
FGILLMLLIIRLIYTIIENHKMACTDSLTKLNNHFSYKLTMKKLENKYNKNITIIGFDLN
GFKLINDTYGHNIGDKALCVFSEILLKVFKNKEFVGRIGGDEFIVISLEDNYENIEIKLK
YLEKLISEYNKESEYRLGTSFGYCTRVKGDKSSLEKIQQEADICMYRNKKLL
>A0A564G4J4|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MQIDLPTLWYLTIGTLLLSAAMTLWERQAHPRRARELGLWAGACLVFALGCVVAMSRQHF
PGVTGAALTNLLMVSGYLLVLQGAAWLDGRPRLLRPALALAGLALVWAIAGTHFPAAFWN
HVAALPIALASGLTAWTLLRSRTVRGLRSRPVAVAVSAGHGLFYLLRALVAPVLVAAYGE
ALLPVFAKVTMFEAVLYSVAMPMAFLALVREEAQGRLLAASRTDHLTGLPNRHGFFEDAG
RILVAQAADRPVSLLAFDLDHFKAINDRHGHAAGDAVLRLFAEVARDMAGPDAVLVRLGG
EEFAALLPGAGGGSARQVGERIAQRFAAAAARRDGLDIPATVSIGLAESRSGPGDLPLLL
SAADRALYRAKALGRNRIEVAEPARAAA
>A0A6N3ESU1|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MVIVIKKSLKKPLLYFYITIIIATIIGCLYSMKINSKNNKIDEVLLITSETIKSDLYDHN
KKSRNRELYDYISKDEINKMIIEFQNHNRLNKAYLLKACVNIADNEYDEAKDNLNKSLRS
VNPFTSIKLKTYAGTFLSKIYLANDDFFKASEVVRYCLANINSKNYNKYYKEIWMLMDTI
SDKESGQSKIILWGTDILESHKNLSNEAKLYFILELKELYIKHGNYAKASEYAIKGCYLA
YDLNDNYCLSRCMINLGRILREIENRDRAVELIKDALELPIEDKSHEAYRDVYAYINLGE
IYLESGNYEEAKKTVENISSYKGYFNEEEFRNIEIRRILILADKNFYENNLDEGKKLLDK
ADELIKENKNNISSDVYLNYNSLHGTYLEQTTNYKEAIELYNEILQWCVDKNDIYNQRKI
MKKIMNVAINSKDYKLEEEYILKLAGLINNTEDIIYSDYSYYVLETVKSEVSIEREKHKN
KFIFKVLSLTLVSSLIIFLISYTKIKKLRVQNQKDGLTKSYNRFYFNELYESFIREDTNF
SIMMIDIDNFKSLNDTYGHQFGDTVLINVCNTISKIIDKDSKLCRYGGEEFVVASSNKSR
QELEEISEKIRVEVEKIAFQQNVKVTLSIGVAMSCDNKEDTLNVADKNLYTAKTTGKNKV
VFEH
>B2U0P0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVGLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>M1ZLN2|diguanylate cyclase|EC 2.7.7.65|[Clostridium] ultunense Esp|TrEMBL
MKDLFNKHNCKYKEMFNNNHTPMLIIDAKTGNIDDANLAACSYYGYIRDKLLKMNIADIN
VLKEEEVEEEIEKAKKEERKFFQFKHKLSNGEIRNVEVYTGPIKLGNKELLFSIIHDSQE
RVELESKYKKNKAYFDNLFHNSPEAIAIVDRDYRVLEINNRFEDVFQYNLKDIREKDLTE
LLCDETLYEASHNFRESIRRGKFIKEEVKRRRKDGKLLDVLLLGFPLVIEGETIGAYCIY
SDIREAKEREKKIELLTKCDVLTGLFNRDFFLSNLDYEILKNKRENRLDEKIVVIILCIN
EFKEIMEALGPLAADNILKEFALRLKEGVGPEDIVARFGEDEFAILIPKIKDMDKLNGLT
GEIIECLNMPFYIDANEIKITTSGGISIYPDNSIETIALVRKAEIAMNKSKELNSNMPIK
FQNSLDKEVQEYFWIKNSLTRALPNKELFLNYQPIYDTSVNRLVGVEALIRWEHKEMGII
PPAKFIPIAERTGLIHPIGDWVLLNACKQNKKWQDLGYEPIYISVNISALQLEKPGFIKV
IERTLEESQLEPKYLQLEITETFFAHKYEYVEDTIGELNELGVKLAIDDFGTGYSSLGQL
CQFSINSIKIDRSLISDVHKKSNKNKVVKAVISLAKSLNIDLIAEGVETQEELRFLKENR
CTVAQGFLFSKPVRAEKIEKSFQKTIRNLYKKYKD
>A0A238DI68|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MAAVLRQTARRGEHTMMNAHEDRFNDGHANPLIEANQQLVLAMLRAQGDLTLAVKALDLV
SRTAERDTLTELPNRTLFLGRFMQAITHAHRNGGHIALLFLDLDHFKMINDTHGHLVGDR
VLKRTANCLVSAVREADTVSRHGGDEFLILLTDITHASDAAAAARKIIAALAQAAFLGDG
LPNLTASIGISVYPEDGEDADTLIHRADMAMYRIKKQMRGHFVFHADPVLGVTKMDAPMP
PPPQVHHSHAPWEDADHGLRHEQLRLANQQLVSAASSAEQLRIATDRAQRRQTEFLTTLT
QRLGESLALIREAAAMLHPSQPEPELPDLAQVRAMLERRLDHASQLLENFQDMQRLYPRK
P
>A0A238DKU6|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MPAPAAALAPRQLTPSGVWRLRLWMVAFTLLVLLYTAWATLQIERRTQAEVNGQLQANAL
LLAELMKKDFSRAQQYGDLLAKGLGAQPELLQPSPSALDLWLDAYDDLSPPRVLFTRILG
AQGQVLASDEPGGVRHREPGAARAMVGLRNGQLEVGAMQHLEGSTLWHVPLRLPVRDAQG
RLIGTIELIMDFSPQASMVEKLSQEQDKQWPGFAAGWIRNDGVMLLRCPLVAEARQPGDY
SKPRQGVLARTLRQEPAAQQGFVRGLVSADKMLRNLAWHRVGAFGITAFVTIPQRDLWIA
LWRNTRLQWFAALAMLVLAWSVFFQAASMMRALRVRSVWDRTYSAVVRAGLKSESLQDLP
RLLCASLLEHGLCSSAWLLRVDEVGDMAVLAHAGPPRLAALPLPCLPLALHSRQQEVLAL
GATPEEGLALPVSMQQTPWAVLVLQGVPRLGRGSERQRATQRGAWRLRQQIELVLDNLRL
RETLANERDSQRHRALHDMLTGLPNRAALTEFLSGWARPGTSGRYALALVDLDDFKQVND
RFGHQAGDVFLREVAQRMRHALRPEDYLVRLGGDEFVIAFAPVRESADIDPALRRLIDQV
QRPLQLAGSGVVTPGLSLGIVWLGATPQSMEALLMLADRALYRSKRNKATRKFAWTMFGA
DIPSHACDDALDLPLALQATEAPAAMDDADAVPTRPLGQT
>A0A238DV06|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MQILMDFLQLTHAEAQALAEFAAELLNRAQAPTLAFQEQVEILSTQGGVLSALSMDQCAQ
LIEMHEDHYRELLAPQYTLQLQHRMIEVGDLYYRWGLPPLWIMTTSSLFAADFEAFAADL
SLPQRRPLMAALYKRLRRDEAWQMEGYRLAGDHVRRQLERSPLRDALTGLLNRAALDEML
PTALDRARRNGTKVAVARLDFDAFRCVNDAHGAVLGDLVLQQLAERLRRALRRTDLVVRL
DADDFVLVLEDIHRLENIAPLLERLQLDLDVPYTLSDTLLWQCPISMGITLYPDDNVDAQ
GLLRHTEQVLREVKANKAQRERFWGVYGQ
>A0A8F8ZN81|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MLLEAASIEDAQVWAERFRQDVAATALVCGEVSISYSASMGVAPLDVRLNSSEQVMQQAD
SALYQAKRQGRNQVMVANVN
>A0A448EJ14|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MKLRDNFKRKTIDRLDYRYHLLLLIVPICLFVLLFIFNAPTEGWTILPLLFVCIIYIFAY
SLIYYLHQGRLTRLWEHLEQVVTINDAIYELAHLSSHYKNEHAFLDALLNKAVYVINGAE
MGSIIKVNEANNKLHFESVVGLDLAKLRQLDFTLEQTFEYRLTKGRCDQVVVINDMKNIN
AASTLTEDDQRVLLTVSKQPIRSTLSSPIRIDGKLYGMLNLDSSSLGAFSDYDRNLVSIL
THEASNAIALYQKSQQITKLANFDPLTGLYNRKNFEDELHHWQHKPHLGSFLIIIDMDNL
KAINDAYGHQTGDVAIKRTATAILTYWQNKGIISRFGGDEFVALCHGPLTQIEQDLDDMR
KTLNQGSELSLAFSFGIAPFETDWYQSFKTADHAMYEQKRAKKKAIKALETFAVKVQ
>A0A380B2F2|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MNLSVQNMIELDSPTLIIAQAIVQWLLAILLMAERGMDKGTKYWVIALFIHGIANLLLFS
RPYLPPVIAVIFYNFCVTTAFSFSYLAFARLVGKQAPLWLVLFPIFVMILTMSIYIDDIA
MRVIFASIITGTQLILMAFILTRGNWYGSEKLKGWLMYSTGLFGVGFIVRALFCYVKPEL
FIHLVAKSSFQSGLVIAGMIYIIFSTVVILLVRLDRLNKELSTLASQDSLTGLFNRRAFM
HNATSIIASENFPVSVLMLDLDNFKKINDVHGHNVGDTVLKLCADALQDGLKQYGIIGRF
GGEEFAAILPRADSEQALVVSEKLRLAIETINVNPDIRLSISIGVATSSSVSSIEPLLIR
ADKALYEAKSKGRNQVIHADLLALN
>A0A7Z7WCG3|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MSKFPFRFAAVAVERSLIPRTFVRQSAISALLCLPLLLSALAADQRALLLGQTGWLAALC
CGALWLYGRNQRRKARATLQDACLGLLEFDLAQQYVRGSVHTLQRLLGLPAHTRGMNCAR
WLMLLHPEDRQLFSNLLQHPPGTPETGYEMRIRHHSGHWEWLEMNLQPSWRNGKVQQLTA
ICRVITARKHDEAAMLQREQQFRTLVENAEDIIARYDLELRCLFINRSVSRFSELPLEEH
LGKTPREKGWSNEASARFEQECQLLINNWEARRFELELQHGQQRHIFEIRLFPEFDKAGM
LKSILSVDRDVTATRQGERLLAEENEVLEMIAGNHPLPQTLEQICQMMESQQPGAMCAVL
LLEENGQSLRFAAGLSLPPAYRKLSERVMVGPSVGSCGTAAHWKRTIVVDDILNSPLWAH
ALHKVQPFGLRACWSMPIFSSDRQLLGTLATYYREPRSPSQEELALAQRITRIIAIALQR
DGHEKQLYRLATQDGLTELNNRRQFIELADREIERSRRHGGRMSVLMMDLDRFKDINDHY
GHAIGDEVIRHFSQVCREVLRASDLCGRLGGEEFAAVLPDTGLDDARQVAERLRGLASSA
RLATVTGPLGYTVSIGVAERRADETDIDEVLGRADKQLYQAKRDGRNRVSGAVPAHSG
>A0A1V5KKE4|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin467|TrEMBL
MVERRRVWLRLVPMALLLLAALILAVHSAAQAGASDAAGIRAAAAAVAALALAMCVARMR
HAFRGDALGLTWSEERYRMLAEASDEVFFEFSLRDGSLTVSNNFARVYGRAPARSFGEFL
KMLHPEDRERYEPRWRALASGADCAHMVADIRLLSSEGDPPRYTWCRMRMRALEDGRGRR
RAVIGKLADISQERLNCERLERKARTDQLTGLLNRAGLEEAIRRRLADRRRSPCAIAILD
VDAFKEINDHYGHDAGDRVLRALSNLLSAQFRETDFVGRFGGDEFMALIDGADSREKLEQ
ALQRLRAEIEGLCVPGVRGKLSASIGAALYPSAGDSFEALYKCADVALYEAKRSGRSGFK
LYGRRAQSAVKTTNISA
>A0A7L6YRK7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C16|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A3P3ZMI8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLDSKPFSGCTEQEYNLSLLPKTCPPQEYIMASEPTPAELAGKTLKALVARKLSPTPENY
ARLYAEISGREIFRPVVPPSGPVAEPAEVRPSLAWGGLIRELLRQIDLPHKGMTLSRKKE
GVNTVLARFGNDSELLYEKLQGLMRSWGSGVVSSGEAPESIENNPPVSPVVSSGPVQPVA
SGMDTAIDPVVMAHLRDLLAQTLESNKLLQPELGEEINILVTQIRAAVNGDQVTDVAKKL
RHFWVKMELRGGDKVKIQEGLLSLLRLLVENVGELVADDKWLHGQISILRDIMEQPLDKR
SIADAEKNLREALVKQSSLKQSLADAKDTLKILMTSFIDRMGEMTESTGDYQAKIEGYNL
KIGLADNLTELGHILEDLMQDTRVIQASTLRSHEELMVARRQAVEAQEKIRLLEQELEQV
SELVREDQLTGALNRRGMEDVLQREITRSNRTQSPLCISLLDIDNFKLFNDLLGHKAGDL
ALMHVSETIKTALRPTDAVARYGGEEFLVVLPATHINEATDILQRLQRLLAQKLFVYDGE
EIIITFSAGVAIRGLNETAEEAIGRADQAMYQAKAAGKNRVIKAEA
>A0A1J5SJ65|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFSNLLHASRSSIQLKLFLSLTAIVALSLTAILASQVYLVQDYFVRQAEANLRSSNYLLS
RVLADPLFEKDLSLLQARLQEVQTKLPLCNFQLKDDIGTVVYKVGEVRAHSDTEFDPNSR
DGCYNTIIPVVHENRLLGTVRMGVRTDDIAQARESLIQHSAFFALFWFAVFMLPFFVQIR
RLVNPLGDLSRAAQEIANGNLDYPTPEPVRGNDEISRLITSFQGMAQALVSNRNTQAASL
AALNNEKSTLDALLATMPVGVIFADRSHIRYCNNAFRQLCLLGPDEDLVGMKNDTMLLRL
GQIAAEADSFLKTLAEILETRKLIEPKYIALKDGRYLRLISNIVIAPESSGYLGRFWLFE
DVTEERRTLHMAELRAEHDALTLLYNRQRYDQDLPRLIAQAERDGSRLALLLFDLDNFKP
INDLHGHAAGDIVLKKIAETLTLQLRRNEVLYRIGGDEFALLLVNASNDEIALLAERIVQ
TVRSLTFDFNGATAKVGCSLGVARFPHDAITLQVLLQLADRAMYEAKLRGKNNWVMHHDT
TRH
>A0A1J5P8W4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MEVSGASSVFLLESEDAEHLVITASVGSPLEPVRLDLAEPSASVVAYRSGAPLYIADVEG
DARVSRRLRGLTGARSLLAQPFSHGGRVRGVVVVSWLEPHPESAAESVSTLALLAEEFGS
ALERMDLNAALEHRATTDPLTGMANRRVWREELPRMMTDPGPLCVALLDLDYFKTYNDTH
GHLAGDTVLASLGRSWLSMLRPQDLLVRWGGEEFALALPDCPVDCALDVLERLRAQVPDG
QAASAGLACWDGVETIEALMSRADAALYEAKRTGRNRSVTSVGGPEGVDRGEPAVAR
>A0A1J5P8V6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDPHVLFEPIRDEAGQIVDLSYLDANRAACEYMNIAHDKLIGMRLLEILPGHVESGTLAR
YIEVIESGRPLALDRYAYQNEILGSVSFSDIRAIRVGDLMVLNWRDVTDRYAADVALAAS
EEQYRLLAENSSDVVLRLNMGVVGWISPSITDMLGWNQSDLLDKHLDELILPEDLEKFLD
CQLTISNEEHLHVTRFRMLAKDKSYHWIEIRAKRYINASGEWDGAVASFHTIDAQVAAEQ
SLERRARHDELTGLLNRNDMLDRLSAISSHSLRTGHEIAVMFCDVDAFKSVNDTRGHATG
DQVLRTIATRIEGSVRSGDLIARIGGDEFVIIIGFLDGDNLAPQLQLVLERLHEAIETPF
DIEEGQLAWVGMSMGVALYPDDGTESDLLLRRADAALYRAKTHKQTQGLWWRRWIEESNT
VKPMKP
>A0A1J5RJR8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSSPPPTPALTPPAEWLELLPACVIVIVDGHFAWANAAALQLMEAEEAADFVGRAVAELV
HPLDLHRVEARIRHAVENAGTNPTTEFRVYTCRGHERVLAMTSRPLDFGGRAAVLAAFLD
MTQRAAMEERLQETDRNFRRIMDTMQDVFYRTDAHGITRYVCPAVQNVLGYRADEIIGLP
AAAFYPDLSERDRLVDAIREHGFVHDFPGRMQRKDGVIIDISISTHALVDERGEFAGVEG
IWRDISQRKAMERELERLASLDDLTGLPNRRCTLQALEHAIERRGGRRETSPLCVLMLDL
DHFKRVNDEHGHLVGDLALQHVASIMQRWSRDGDVLGRLGGEEFLLIVDAADLDATLDVA
ERIREAVQDMPPPERPGLALTVSIGVAQWRETDVDASRLLDRVDRAMYAAKNSGRNRVCT
SSNELPNGPIASSI
>A0A1J5QDJ4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDSQFYQDILDQISDGVYFVTRDRHITYWNGGAQRITGFDAGDVLGHSCAEGILRHVNDA
GRQLCVHGCPLAGVMKDGLPRETHIYLHHKDGHRVPVTVRGHPLRNSDGKVVGAVEVFSP
RVANMYAGRRSTDNDDQMDPVTGLPPRRLGELHLRTLMGAVAERSTTLGVLFIDADHFKA
INDTFGHKAGDDVLRMVAQSTANGLRHGDIPVRWGGEEFLVMLPGIDQRGLDATAERVRM
LVENSWIQRGAVQARVTVSIGATLAVPTESTDELLDRSDRLMYASKNAGRNRVTTDTGAL
TNTSERPILGTDIPWLMPGVPDVDGFGCG
>A0A1J5TJN6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MISHQTDLEFVHRVQNAIDMLPSPIFIKDGAGRYIACNRAFESYIGVPRSELCGATVYDI
APAELAAIYEKADLDLMAKGGTQSYEANVRYADGSYHDVIFFKSVFHNAEGKTDGISGVI
LDITERKRLESELAQAARVDFLTGALNLRTFYDLANQQFTSFKRTGEEFSLLMIDLDYFK
EINDTLGHDAGDDALRKFVQTAKTNLREQDIFARTGGDEFRLLLPGTSQSGAMLLAERIR
EEVNQVKIGTPNGSIALSMSTGLCSSLPDDHSIDSIVSRADVALYRAKAAGRNTVKAHGH
IDCKYHPDVKTDSVSF
>A0A1C6L1G6|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MQMQKLAERKKALVFAAVFLIVNVVGIFFISIHESKMIDKYLIEEASDTRHDFNDVLKDY
KHSFQIFSEMLSREIENNPDPDQIWDYLKTIDSTMLDIEGDTFDGLYMYYKGRYLYSWDT
PYSEYEKSGYVATERPWYKDAAAGDGEIVFTPPYMSYANHYILSTISQLQPDKETVFAYD
IKMGNIQALINSMNHFEDEQVILYNQNGTIIGSTDDDYLGSSFHDSIPEAKQRIEEANAE
LSAIDQEDADEIEKAKEKIASATSFYKFRESFQDNLTLLSKNEKEAHSISIGGSRYYGYL
LQEEEYSFLVLIPFFSVLKATLSSWLVPLLLVELFLIYVLSQVNRGLKNRELKEAYVELG
QTQRRLEMALQVAQKEAAIDELTGMMNFSSFRKNMTKILTEMEPEDGGIFIMIDGDHFKQ
VNDNYGHNIGDEVIKLTAQMIVGRIRTIDIASRLHGDEFAIFVADTEDYSVAQRIMEDIN
QTLAKEAAKRKMPAITLSAGAVLAKQGDTYVALSKAADVALYRAKETHDGGFAHK
>A0A6N3E329|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MIYPEMPANETERIKSLYMMDLLDKKDDARFDRLTRLAKAAFDVPIALISLLDRDRQWLA
SCSGDIGVRETARNISFCAHAILAQGIFIVKDASIDERFHDHPFVQGEPHIRFYAGCPVR
LPDGAIAGTICIIDNKPRDLSPENINTLIDIGAIVEDELYIISMAMTDSLTGLPNKRGFY
KLGEKRFKWLSDNKRSFSLVYLDVENITAVNDFFGHHEGDSMLKRFSTSLGQCLHKNDIA
ARVEGGKFVVMLGHDDDRDVDTFLFSLQSRIDDLNEKAHEKYRLHYAYGIVPYDPDQYGN
LVEMVNNSERVMYLERKNPPQRSFNPTSNKPA
>A0A6N3HY59|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MKTPALPIDEEQRLASLHDSGLLDTGTSERFERLTRLAKRLFNVPIALVTLVDGQYLRFK
TSDGQAHDPFPRDISFCGHTILSPQPLIVNDAGSDERFADNPLVTGEAHLRFYAGHPLRL
PDGAVAGSFCLLDRAPRDFSPAELDILRDFALIVENEFAVMSAATTDELTGLFNRRAFES
LVKFTISSARRRAEPLTLGWLDLNGFKQINDTLGHNEGDEALRAMASIMRSNFRDADILV
RYGGDEFAILFSDTSEDGAWIAMQHLAEQTEAWNASSGKPWKLAFSWGVSEFNHDGDGDV
KAWIKDADKKMYDMKTSGRPR
>A0A2H6B5Z9|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MNERSHRSSRVNAVGGLLVLTAAFAVAAVYHAATWDRPHREAMVAMLVAVYLLSLLIVAL
PPSLVFATRRRRVGVAAFWNLVCVALVAVSAALDGGLRSPIAAMMFVAVVFASVSYASVA
LVAAVGFAGLASSVAVGALVGGASWPYVTMFTSALAIVAGTCVWQAHMGRRRRRQLAEAS
RTDPLTGCLNRRGFVEQYERAVGEAERTGTPFALVEFDIDGFKEVNDVYGHEAGDRLLVQ
LVRRVRGVLRSADEIARLGGDEFVVLAAGADREGAQALVERIERALSPQTGSIGVAVYPH
DGRTLDELYRAADAGVYKTKRSRRSEGKGTRTPGEAN
>A0A5W1NIZ3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPMTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2H6B8P1|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MIGGSTTAASDHGENTSLSLADQLRRERLLDIEERISRYRRMTFAVLALSLLLATPELGA
WWLFPFFATVVAFPVCERLMRRAANPFPWAAAGWAVSPLAISVAVALTGGPESPGVPWLA
LPAITLAARFERQGVLIGSAYIYALLFASTVAIDPAAVAERPSRVIFPMALVLGAILLST
ATVESDRKHRREALVDPLTGLLNRAALRLRLDQLLRDPAQAQAPRALAFAIGDIDRFKEI
NDTYGHLVGDEVLRTVARAMRKSLRGGDQLFRIGGEEFVALLPLADRERAVAVCERLRQA
VAAARAPSGLTVTISFGVTIARGADVTLEQLVAEADEALYRAKRAGRDRVELAARQRDDP
ALAAQAPH
>A0A518LMF8|diguanylate cyclase|EC 2.7.7.65|Phycisphaerae bacterium RAS2|TrEMBL
MAESAIQLRRGLFGLQFRTTALLAVIVVVATGLCGWTYSRFSSSLTLAESRRHTTDIARA
VAFSSSGEVAQQDRSALTRTAQACVSQGEIAYLVFTDISGEILASCQRGAGNINSLLVDG
TNRVLVDPINQPRLLHHGEFGPRIDVVYPVTVISPEASGLAAPTVGFVRLGVSMTSAGAR
LARLRQDIIWLCVAVALLMVPVGFQAVRVVIAPINRLAEAVTAFAAGQRDVRVAVSQHEW
GEIADLKRAFNGMADQLNGSHEKLVKLNAELEDRVRERTLDLERANMRLAEMASRDSLTG
LYNRRHFNDVLAQLFAEAARYNTEITCMMLDLDNFKQVNDTLGHHMGDQLLQITSEVLLA
CIREADVPVRYGGDEFAVLFPRTTPAEATASAERILTRFKRELLRRMPDAHFVSLSIGLA
SREDNLPGTCIELVHLADEALYKAKAAGKNQIKSIRPSQVRRNPSQQVQA
>A0A1C6GHX7|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MGGLIVLKILYVEISIIGIVILLAIRFYLRKREYTKDLDKRTFKWLIWSDILILIFDAIT
WVMDGLEFSCSEELFLVSMMIYYCLVPLPSLFWLLYTDVKLHADQQRLKRLLILYSIPCV
ISTILVLTTLKTGWIFTIGSDGVYYRGPYMVVIILLTYVYLGGALAMAIRERCREKNPDR
IKVCRYLIFFPIPTIILSFVQVELYGVTLIWICMAVSLLIIFLNVQSEQISKDTLTGLLN
RGYLDSYLDRILTTSKGKPEVRAKYFAMIVDMDDFKQVNDTFGHVEGDKLLVAAANLLKQ
SCRLDDVVTRMGGDEFFIIGQRDNRDEVRCLRDEILDNVRLYNERSNEPYSMCMSLGFAM
LDKQIKRPDQFITAADINMYRNKEKKKANN
>A0A8F6GV08|diguanylate cyclase|EC 2.7.7.65|Methylococcus sp. Mc7|TrEMBL
MRIELQNLTVALAYAAAGLGTSTLLAGCSFFPSPFWPPAGIALAAALLGGARLWPGIFAG
AFFVNWRLFGEPFPLAAAISLVNVATPVLGALLVRWTTRSKQPFFRLRHVVCFVVFGALV
PACLAASAGIALAVSAGLVPLRGVDSAWWRWTLSEAGGIFLLGPTLILWCGRRRERRLAG
KPGEAVTVAASTLVFAAAVFLGIRAPTHPFEGLPYLLFAPILWLTVRSSLHAATALLSAV
ALIAIGGTLLRHGPFHLLGSTQPLLNVGLLVVALGTSTLATGALVSERRAAEEKLLRMNE
TLERRVAERTEELHYRATHDGLTDVCNRAYFFERGEAMLAEARDSGRPLAALIIDIDDLK
VINDSYGHHMGDAAITRVAEACGAGLRAGDLVGRIGGDEFAALLPDTSAADARRVTARIA
RTLRSASASEPGVGASIGVAVREESDTGLDALLRRADAAMYAEKQSRSGGEP
>A0A6M3NZE0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X3GQN6|diguanylate cyclase|EC 2.7.7.65|Listeria fleischmannii subsp. fleischmannii|TrEMBL
MNLLMTFGANIFIASAGTYFIFKMIPYQINPKLLLWRKTVIILLILIINFLLMNFAFELP
DGVRLDLRYVSIILIAVLASPLFTISTAALIGLARFLLGNVSVSLQAFLFIMVLAVLASF
WTYMRKNKVHESRLIFELYIISVVVNLINMSFFYGFHFKLVVLAIIWMLFNGLSLLLLYG
VLYDMRHTRHLYIIETERAFTDALTNLSNRRAFDQHIRLHSKDVTVKKLSALMLDIDLFK
SVNDTYGHPAGDKVLQSCASIIQEHCFEKGHAYRLGGEEFCILGVNFDQDTAFKLAEKIR
LAIQHTPIPIDAHQKIAITISIGVATAYLSTDFEYIHHFADKALYEAKNNGRNQTISL
>A0A1E3A753|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MIEKELCALTKQLMLTCMGGRNLDKIQEITGFFTNNAVVIGSRSDEFYTSVEQIENALNN
DKWKEGRNYICRPVKEWFQCIPLSEKVFLVCGNIRLEMIFGSGDAGEAAQDYRAGLSEAD
VRVSVVWKLEKEQIHALHIHFSLPEEDFLPCRAEDLTGTAADEYHGSADRKEAAYYKKLS
ERDLMTGLYNRGSFEKYVKLQLNEVGGGTFYMIDLDDFKAVNDTYGHVAGDRVIAGMAGI
LREVFGESAVIGRLGGDEFAVFENGGSSRKESEEKARRVMQAYRLMSEKYGNEILLSCSI
GLYREKGKETFENLYSCADEALYFSKNSYKGTFHWYYRQCRT
>A0A1E7WZP8|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MAAAMTIVLFSAYRSFPADVQGLGHQSLGMLSLTASGLLFCAGPLIPEAVLLFAANSTML
GAAGLMLIGTQLFFGRKPSWWWLALAWVIGMVCLVGWYVITQDYALRVAVFSLLTLSFYV
AQLVLLVRHGERHFSSWFFGTLLLVQSLVLLLRLFAALSGAVGTSNASNGAVQGIFLLTA
NFMTLMMAVGFMTIATRRLQVVMEHRSNSDPLTGVLNRRGFAAAYHREVALMKRHGKPMT
LLSIDLDYFKAINDQYGHAVGDRVLVHAAHTTVSALREIDHVARFGGEEFIVLLSGTTAE
QAKATAQRIRASLFEARGGDVPDYTVSIGIASQQAPDESLEALMARADAGLYRAKAAGRD
RSEAA
>A0A6N3QIJ6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKYPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1E7WTQ0|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MDVRHLRMALDAARMTIWDTAIHDGTVYNSTVSWQCSGQCLLGLPPGRLTQPFVDFLSYV
HPDDRDALATIMQEAVDAGTGYEVEYRVVWDDGSLHWLAAKAHMHCDAHGAPVGTLGVVW
DITDRKLAEQASARDREMATVTLRAIGEGVITIDPHGKTEYLNRTAEQLTGWANDEARGQ
DIAITLHLTSEAGEPIAEHVALRCLRLRQTVAPASDNQLVTRAGRRIAVEESASPIWADN
GALLGVVVVFRDVSHERKLTRQLSWNASHDTLTGLINRREFEARIAEALHSAKEEGHVHA
MLYMDLDQFKIVNDTCGHAAGDLLLQLLARMLQTQMRDSDVLARLGGDELGVLLPRCAID
QARLIAEGLRQSIRNFRFVWQDRTFELGVSIGMVEVTRHNKSMTELLMAADQACYLAKER
GRNRVHVYRESDQRLARRLGEMQWVSRLNEAFEQQYFRLYTQPIVGLGEHGSDHLEVLIR
IQPAKGDLILPGAFIPAAERYDMMNAIDRWVIRAVCRHAGESASAPVEYSINLSGTSLAD
ESLHDYIVEQFREFNVAPQHICFEITETAVIANLIKAQEFMARLKALGCRFSLDDFGSGL
SSFAYLKALPVDFLKIDGVFIRDIATNSINRAMVKAINEVGHVMGLRTVAEYVEDDATLD
VVRDLGVDYAQGYAVGPLRPLAP
>A0A212LXV0|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MQQGKTTIGRIPWEISYLLSLVIKASHDRDVYLDNITIKKVNDSQMIQHRQTLKNISFIL
LFILLIIGLSNSSHAASNIFLTEEEQAYIAKKGVIKAVSLDGIAPIQYSDKNKEVQGISK
RVLQEISTLTGLTFEYTLYGSLREVFESNAEIAFGIPNNYAPPDMILSKPYLRSETILYI
NASQDPNNLDNKIYAAVRGSALPKGIKEENSIYFETREQSLDAVEAGRADYGYGNAYSVA
FYTLQNGYKNLVTIPKGKEARAYCIGFFHEDEILISIINKALSAIGENQLQNLVLDVAAQ
VERKITFSMVINRYGKEITFIIIGVLSILLFAITSNVKANKTLRMNNRRYEVLSEISNEY
LFEYFTKTNRLQLSESFIQQVGTQDNLNEANSILKNMLANTAADRQYFEIKLPLANGEVG
IFKVIHLSVSDDDGNLVSIIGKVVNISDEAAKREELANKALLDGLTGLYNAITTKELIQT
AICSRQEKQRMDAFILIDLDYFKDINDTHGHLAGDNVLLQLGKVLKQSFRTTDIIGRIGG
DEFGIYMPNIPSLDFVKTRCQKVSTLINTAIEDMPVTISVGITLVDQDMEYEEIFKSADE
VLYQAKRNGRNQIVAWEER
>A0A2D8QCV1|diguanylate cyclase|EC 2.7.7.65|Tistrella sp|TrEMBL
MPTTAGKTAARHDTAADPNPSLMAARRDWHRLQAALAPEMRDWLAGLVSASSDELARDFY
DVLMADAEAAPLLSNEIVQTRLRGSLAGWIRSLFPAGPAPDFDSMATVQTRVGEVHARVR
VPLHLVSRGARLIKAGIAGRIAGSRVSRDDLVRLLLHVETVIDIAIELMGTVFVSGLAHQ
SRDEEAYRLFFLSQDLSLERESQRASLLEWNQAVLLALAGGSGSTEPLPRIGRSDFGLWF
HHRGGIMFDGTPVLDRVNELMQRLDEAILPETDAARAAGNGFGPALGPIQDAVNEIRFIL
NDAFQALIGAEAGRDALTRTLNRRFLPAILKREITLAMRRDHPFAVIMVDLDHFKTINDT
HGHSAGDTALRQAAETILGTCRSSDLVFRYGGEEFLVVAVEAGEAAARALAERLREAIGK
TEVVLSGDTRIRLGASVGVAVFDGHPDYNHLVEAADSAMYQAKRAGRNRVVVAGSR
>A0A8J7VYE8|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MIKNVNGIISIIMASLLLVIFILCTLFPGENLQFNTEPVTDLNEDWIYMEPDGTQLNLNL
PARLKVEAGEKYAVRIWLDRDFSERKTLCIRTSMQTLQVLLDQDEIYSQGIEKPKSSITI
PMASMWNLVRLPEDSDGKELTLIFSSPFSSFSGCVNPIVYGTKSAVLYDLLEKYWFGLFV
SFLIMLIGFLLITVPLIVRTKDWALFYLGLFSVFISLWLLAESKMLQFFTGNQFIIGGLA
YIMLSLFPIPMLLYIRETVVTRWKRIYFCLACAFLINTVLCTLLQITDIWGFFGSLVLTH
ILLITGIAFTVLSLVLEIIKFKNKNALGFACTISILFTFAAVEFYGFFSRNFTDVSTYVR
MGLILYICILGLSSLHRWRDVINKSREAQFFERMAYQDILTGGKNRRAFDNDIEHYFSAG
AAGLKDFRLVIFDTNDLKYINDKFGHVTGDEALRKSYDCIEKAFSLSGSCYRIGGDEFAC
ILPRCNDECYQELLTAFRRLVKEIGSNTAYPFEIAVGSAVFDPHRDSGFQGFLNRTDQAM
YENKESFPDLYLQYL
>A0A8J8B0Q7|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MVYTLLILSTLVVLYFLLLVAQRKQKKQIHYAVLSITISILIWNVAVLLYQTFDNVPWIL
SICERLYFLGTILISISILFTGLIFARTKIKFTWKHTLLFIVPVISIAVLLTNQSHHLFY
TTFSLIPSEQNFGIYFTIHTIYSYLCIGIGLAYLIVFSIKNYGVFSKQSLLIFIGLMISL
IIDAISTFKIFDWSTAIENIAFAVTISFFILATVKFDFLNVIPIALQTVVDLISDSYVVI
NEDFEIIDYNKAFVGGFAGAARKVGIMEIIKKNYSDSDFKKFMDVLDEAVHEQKKVSFEI
SRSVGKDLTYYMVEITPIYISGNHIGTIILKKDITEHKNNLKKVMQLNEKLQSLATRDWL
TQSYNRYFFDERLQQEIDRVNRLQIYGQEPCKGANNFGLIMFDIDYFKIYNDNNGHLTGD
ELLQTIVTVVKEVLYPTDILCRYGGEEFAVICCQTSEEGIRIVAEKIRKAVENYDFMFQD
KQPGGNLTVSVGAVCCSTNAKKDDLIKRADNNLYLAKSGGKNKVVF
>A0A1C5PPE8|diguanylate cyclase|EC 2.7.7.65|uncultured Faecalibacterium sp|TrEMBL
MDVPVRFIDSIVNNPLLMQFLVHRWFFLLEYDPRLDQLRVYDTRSRTLETLDAYLGSEKP
EHATIFAEDRWKMRALLTGELYGPLEMRFVSPEGVYYSREVDARPVEDPARGTLYVGYAK
DITDQKNQTQELLEQARHDSLTQLYNNRTGKELIDRYLQAKDPYASCGMLVIDLDFFKNV
NDCYGHLFGDKVLQEFARLLRTLFRSSDILVRFGGDEFVVFLKDIPNTTLLQKTRQLSES
VQQVKFWENDYRMTCSIGACFLPENTAGYSFDQLFENADWALYQAKQNGRNQYVFCDNLR
RYAQAVPAGADGCVCH
>A0A2S6Q6C4|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MFFKNLIKSGWLHAVFIAVIAYPMASMTQKFVASYTDANLLAYTAVFMLCSSISLLVIAG
PGELANATLKRFETWLYAFLQIFSYILFLYSVLYASATQAAALTMIGGLFILIFSIMFLR
QPTNRYEILGSVVMVYGLFLIIAESNLSLEHKAILTFIVVLRGLVISFQKIITEIHKTNR
KATSFKSQMRVTGFIMAVASFVYLIFLLIMAYIKQQHDIAFLKPFPYYSDFANFDMFIFS
MFVGFIVVSSSKYCEFYAGKSIGAKYLTAITSLQIVFVYGLEIFLSKLNLVEHTQVDHSI
IGALALILLGNFVISLAGFIKDIKFIKLGEKQDTLANLEDNYIDNEQDYKLVRLNISNLL
ALYDDNIEKLAQDLKLEVSKLEEVQDNDFVEGLLHSKTAGIINNFASKNVAIKDQLTKAY
NRYYLQHKAEEMFMKNMDFKVYYLDLNKFKPVNDKYGHDAGDYVLAQVVERLNSINYFKE
SVYRIGGDEFILIQTLDLDLDLTSLILQKVEQNICLPEPQEDICISTSVGVVASINCNGI
EDMLNQADHLMYKDKNKK
>A0A7T5FDF0|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum|TrEMBL
MPSTSPEQQAVEWKLMLMQFPAAVAAQVRELAATHQAELAGYFYEQMLQDEQAMLFLTHE
QVKSRLHGTLQQWIVSLFSSTSDETALLALIAQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFELLCRQPLDTEHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQH
IGVEQERQRSALLDWENQLMFDLAVGQFAAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQSMQQIDEVLLPLFEKAVAEPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDHFKQINDEFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDVHLGQALGVAEKLRQQAEKERFRLSSEHDLQLT
VSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVVLARELPG
>U9Y540|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 113303|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2S6Q6Z3|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MKVLKRFDGWLHGLYMACIAFPLYNIGAKYAIEQYQASPLVFLCFSSLFSSLFLLLFAGR
GTLALKSIRTLDTWVFSFLNLAALSFGLSLLVYVSALQGSILIRLTSFVCFVIAVIMGQS
TNRREFFFSMVAFSGIALLFMNLDLTKEQKAIALLLLVGASLCQALRQLLSEFHKTNIQA
KSTKESARVAGVVSSVSALVLVFSLLFISIYQKAFGVVILKSAPDILDFFNLGTIICAAV
VGLFYAGAVYSEFYASKRISAKYLSAMIALMPMFVLIYEVLVNFILSKPIVLDKIDVISL
ALLVLGNLGIAITAIIEMKRGKETELREKYIVASDENIKYAIELVKSTMVFTHNDIKETI
RLLGIDESVIVDLLALEDGETSSLSKLQFHTINKNYYLGVSTKDSLTKINNRGALEQKVK
DILYRKEKFSLCFIDLDKFKPINDIYGHDVGDEVLKHVADLMLSINPKGINGRNGGDEFI
MICFDNSIESKVDKFREQLSKVFAVNDISIKINASIGIAQSDGKMLLDELIKLADEKMYD
DKKSAS
>A0A857JQR9|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MRRILDVSKGNKKLTLTVYLTLIGFVFLTAFGFISWYNSNIKTSSTLFTAVFFGVINLYL
LKTKYRDFTRYILSIIVALIGLSLLAFGGQDATGYLWTFPLMAMALAVLSVREGMCFAAA
YLLGSFSVLFLPLGSETFVHYEPVTATRYFLSAFALCCITLVLVNIQENTNRQLRLKTVK
DDLTGLFNRAILDHNTIEQINLARNERSDYLLLIDIDHFKKINDNFGHSTGDEILVILGE
ILNTSMRDSDLAIRWGGEEFLVILQRCPSVHAQKIANQIRIEFEQNQRILQLLQRPATLS
IGIAATSQNLMFDKALSLADSRLYKAKSQGRNRVVFSE
>A0A7H4M7U3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MLTNFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITIALLILNALI
WPSVAYLASMMSKDMLGTEKKNMILDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALTCMMISFLTVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLSVVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRTHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISSILRDCAGEKDVPARFGGDELAIIVNNSNNKLVIAMVHIIQKKIKDL
SLPSHKDIYCTVSIGVSCAENKESIIEWIKEADEMLYEVKRNGKNGYCMPNN
>A0A379ISQ1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MAFDAPTMLTLTVALALAAALYLAVEWRNVRESPLLFWSAGFATIAIGSTLALLRGSGLI
LIGIWFANGLLVTAHWLFLLGVARFTEARFSRAWYLIFVAWLAMLLLPEGPQWSRVMLFT
NSMLVALVTLKASALLRPHGKSLSVGAVQLRYVLLMHGLFYAAKAMTAVIPGALIDLNAF
RGLIIQVSLVEGAMALMLIALSMTGTVRWRREKRIERLAARDPLTALYNRRALEARAGKL
LKETSPTRPGALLLIDIDNFKQVNDLHGHLAGDRLLIALGEMLRALLPERALTARLGGDE
FVILMDDASNARVVALGDALRQRFNHMAAQAFATPQAVTLSIGATLFDRPPASLAALIEQ
GDTALYQSKRGGRNSTRVDDRTEAHRGRADGGAP
>A0A2H6J8R6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin12|TrEMBL
MKHPPHQPHPPQDGRPPRGLRRDARIQASRLDLLYARHRGGSLAALLFVALLYPALRPIV
PPLQLIPWLVLAALLVVARFGLVHAYWRRKRPLDLGVWYRRFNVATLAAGLVWGTGAVLV
ARFGGPVHQMFLSFTLWGLGAAALSGMAASAASFLLFLVPAFVPPVLWLCLSGDPLHVAI
GAMTLAFGALLALTARRLDRTLARSFQLGIENTDLIEHLATARRQSDHARTQIETTNVAL
GKEVHERRRAEDKIRSSETQLRSILHNLQDVVYRTDACGRIVWATPSVEQLLAYPPEEFT
GMTFADLYRDPDAAAGMERELEVHFGILENFEVALRTRTGATVWASINAHFYHDAAGAIA
GIEGGIRDISGLKYAREALHKEKEKIQVTLESIGDGVLTTDVTGIIEYLNPTAERLTGWH
LLEARGLPLHKILHLIDETTRRAVANPVKRCLRENRATVVPGNTTLLHRGAEHEHSIEVT
AAPIRDGADRVIGAVVALHDVTRLRGLARQMSHQATHDALTGLINRREFEVRVKNALITA
RNDHKHHALCYIDLDQFKVVNDTCGHGAGDELLKQLTHLFRDKIRESDTIARLGGDEFGA
LLEGCPLQNARLVAEDLRRSVEAFRFTWESNTFRVSASIGLVPITADSGTLSDVLSAADA
ACYVAKDQGRNRVHLYQPDDGAVAQRQGEMQWIHRIQLALDEDRFRLYYQPILPISHRST
AGRHCELLLRMLDRTGEVIPPCAFIPAAERYHLMPAVDRWVVHSAITSMARGEGVLKDMD
SCSINLSGQSLSDEGFLEFFVDLIETSGIDAHHVCLEITETAVIANLASAGRFISVLREM
GCRFALDDFGSGLSSFAYLKNLAVDYLKLDGSYVKNLVHDGTDRAMVKAINQVAHAMGIQ
TTAEFVESENILKILRMFKVDYAQGYHIGKPQPLDAPIAASAVTPGPLRQGQSA
>A0A379IT10|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MATQTARLLKRLRNDFQLSIITLMGLFGVIGISPYAVYRLLHGNYLVGIADTIIVLSTLF
AVLYAWVTRDTIKPGIYLAAVFSVGATLIAINLGVNGLFWIYPLILFNFFMVSPGKALLA
TALVLVSLVSHALLVPGSVFESHYQMVSFLVTSMMASVLSFIFAFRTRTQRDQLQLLAIH
DPLTGARNRRAMNEELKIAMASHRRHSDSYGLLVMDLDHFKQINDRFGHHVGDQVLVAFV
ELIKRYCRKEDRLFRFGGEEFLLLLPSTEAEGLRTAAQNLLGKVANELQSPGGTVTVSIG
GAILHGGEHWESWLQRADECLYRAKSEGRNRAVIADAQDTVARH
>A0A3S4SXP1|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MERYETPWVEAVARLEVALVTEAMALLEAGIWTWSVEQGLRRDPSCLQLLGLGEYGLDDL
GWLARVHPDDAARLEEAIRACQAGHSNGLRLEYRILHHQGHYVRLEERVRRDEQGHLLGV
VRHLDPAAPPLGDRHDTDPLTGLESRGHFELLLDERLAGESGNFCLLQFTVDHRSKILQL
FGEAACDAMLAKLARIVRHELRREDPFARWDEDGFILMLSQTDRLSGLEIAERLRMEIAD
ASLLPERPVTVSIGLVQSQPAEQIDHLLARLASCHGQARREHNTVIG
>A0A3S4SVV3|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MKTLPSLSIHPARLFSLSPCRRCVLLALLGSLLLVACLDAYCFDSLAQNHLRTIGALAEA
INVVTLLFMFWVVQCAQISSKTYFFLSAGLGVWLVSGAIDVMDEAYFQPWWLSTVEDSLR
SLGMLATAWGVLLLLQQMHGTHLRLASLAMSDELTGLSNRRSFRSVLEARAEAGTPLLLL
DLDHFKQINDRYGHGIGDNVLREFGCLLRQHCPPNGVVARLGGEEFALWLPGTPAEQAHA
LAEQMRRATETLVSGDGVRFTVSIAVGVCHAGEAVEALFRRTDLALYRAKHLGRNRVELA
>A0A448L131|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MLPDTDTIKISDVSEGVVHGILEVISEGVWDWNANTGFVYRNSGWYRMLGYEPHSLGNTV
FTWENVIHPDDLARVMACFDAYLSGEAPHYKVEYRCRTRDGDFAWVEDYGRIIARNPDGS
VARMIGAHRDIHAQKLLYTRLELQNRSLEQQVAERTAELQRLNRELQRQVEENRRLAETD
SLTGAASRYRLEQVIRLESERAKRFKDHFSVIAMDVDDFKRINDRYGHAVGDQTLIDIVR
LARDNIREIDLIARWGGDEFMLILPNTRLPDAQVVAEKLRQRLSQLSVGEQEGITMSFGL
VEYHLSESQSQLMVRVDRALYQAKLSGKNQLCGWH
>A0A5P9D8C7|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. THAF82|TrEMBL
MSSFLANRSIAFKLALVCWVPVLALIAISAQKIHVEYQAWQRAEAIGEVLNVAPILSDLV
HDIQRERGTSAGLVGSRGLAFKQSIKDERSETDADLKRLQATVGTPSGKLAASNFTDPYN
GALADLKNLTKIRQEVDALQITVPDIANYYTGIVAQLLEAIEKMKLSVDNAEVLHQISAY
IALQHAKEHAGLERAMGAVGFGSGSFEPETYQRFLSLVAQQDNMFSQFRQNAPTEALVLL
SKLQHGPLETRVQEYREIAQQSPYGTSTALVSGKDWWDATTARIDALKSIEDRLSRSLHD
WALEACQKAWTSFLTLTAFLVALVAGAALVSLLVYREIQPPIARINSSMASWASDGAIPD
LKEAQRRDGIGELARTLNDLRHRLEDTRKIELERNARERAQTQEMKLLSDLNEWLQSSTS
TDELYAMIETFMAKLLPESSGSVYVFSNSRDVLDGTCAWNGGELHEHIRPDDCWSLRRGR
GYSFKTDDIKFACEHTQPHDDGPYYCIPILAHGETVGMMHLKPLPDISTDAFFESYRLAQ
LAAEQISLAIANSKMRDQLHQQSIRDPLTGLFNRRHFIEVLRRNVETSKRTKAPFVLASI
DVDHFKRFNDNHGHDAGDMVLRAVGSTLEQACGVEELPCRIGGEEFMLLLSDTTLEAAEN
RAEEIRQLIEKITVRYGEKSLPKITISVGLSAYPEHGSLPQDLMQSADDALYKSKAAGRN
QVTIANLAKEVPDQPTVDFDRVKEELIDHVDQRVAKI
>A0A822V799|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. B6|TrEMBL
MFTVLECVAIQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVFAVIGFWLALTARSQAAYSPVIVGTLITLS
VAVMHFVGMAGMDVAATISYRWWPVLGGFAVAWVSFLLAFFLFRRIGSWKRIAAPAASAI
FAICALHFTTMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSSTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGRDEASLVGQNPDDLFKAIDGQPAYLP
RHTPVEAVRERAGQAQIFELSVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLYQQIEHCDEDDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTRAEGARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGRDHESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKVAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKTT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVRTTTRKKHSV
>Q3Z2C6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSP
EQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGN
RHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIE
KVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLL
WRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVL
FWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVM
FIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQ
IAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A3S5AWW6|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MKVKYLIYFFTFLLTASFTIAICDEWTEAKKQYNDSAWNLNKTLHSEEVSSALQNTLRLH
TVKRLSLVNPELKPALWQESERETRNNIRQIRRYVNSDALQHLTTQQKIDIRSMLNLLEK
MLDNDTQQLAPMNNAIRNLFNINSAYYITQSSMDYYSYTYESRILNADAFLFLESIRLNN
QLNITLTEIIDQLVDITLNGQNDKESYLKTIQLTGVLNVLSSRLLFMEMVYSDPQISRII
NQLLEKLSPQQTDGLAGELYDSMAHGKAFDAARIYAYVKEMGQLSQQLFQRSFELEIAKC
RKQMYQSQTAINGLFAFAWLLALFLLMPTLIFCSNISRWLTKTQSNIQRLSHGDMAIDAP
EVFYSQELIAITEAINQLKQYHLEKVRLEQEKHALITELEASSYLDPLTNIYNRRRFFRD
AEQLPDASYPLAFCLIDIDNFKALNDTYGHNIGDLALVAFADLLRHAFRAEDIFCRYGGE
EFAILLHHCALPDARMALEKLRHKVQRLRLPVPDGQPVRFTISCGIAAVASPRQLQTAIK
LADEALYFCKKNGKDRVAINDGSSCR
>G8AK65|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MPQTSTQVRRPSHRERDRFVGFAFAAADLLIETDARGTILFSAGARCRLTEGDVAGLVGS
NLLDVVAPNDRKYVTVLFKRIQDKGRIKPARVVFQGCDGNRFPALLGGCRLDSCPGSLFL
TVLLASGPRNTNEALAAAGQLLDGNAFSHILEDRILKAREKGLDNALTLLLIDGLQSMVD
ALPEGAASEVMQGIEAYLRAISANGDSAGQLATDRYGIVHASDIDGQEVQDHITQIIQSV
GGELPGGIRTWSLDVSDERLDPADAARALVYTVQAFASAQGGEFTISSLEDGAKRMLSDA
VDRIGRLRATIEKRDFFVVYQPIVDIGTRTVHHLEALTRVEGMPSPADFITFAEDVGLIY
DFDLLLTQSVLDTMHAHRKEPTLPDVAINLSAKTLMSPIFLRQFLAVTEPYGELARKLLV
EVTETVVVTDIAKLNEVLQKLRAAGFRICLDDVGAGSTSFQSLYGIQADFAKIDGHFVRG
AVNNGRDMAMLRSIVDVCGQLGLGLIGEQVEGPEHAQLLTELGVPLAQGYLYSRPSRDFA
YFAKDWAKMAGTGGKVLRKG
>A0A447QQI3|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MISKHGLPGAVRLINLFLLVFFLSLVGIFSRPLDSLSLFWPVNAILLGVLLRKPAYAGPS
GWLVTYIAMIGADLTTGEGWMLALWLNLCNMSLVATGYGVMRLLPQSQRRMGNPQAILYL
FAASLAGAVVASTLSVLRNDSLYNNTVLTAWLAWFSEQFSTTLLILPVLLAAPRLKTLLR
MQYHWNLRDSLPLLALLGSLLFSIYIGGPGAIAFPIPALLWCAVRYQLFTVTLLALLTGV
VEICAISANVMLYETPASRGALLDTLMSARLGIAMLVMGPLILSSSMVANRKLVRRLEHS
GNHDFLTGTLTRSALTRKARELLEHKRRSKEAVSLLLIDIDHFKLINDTHGHIVGDRVLT
HVTHVLRRELRRDQPLGRLGGEEFAAVLPRALAAQAVALGEFLRQQVEKSEVNIGHKPLK
ITISVGVASLAMKEVKSWEQLMNMADIALYRAKSLGRNRVESFNAVSGSSVDHIWFKE
>A0A2X2LZD5|diguanylate cyclase|EC 2.7.7.65|Streptomyces griseus|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQSVADGIVAGLGYELGCVNLVRPDGD
LVIAAFAGNAAAEALITGRVGSRASWERRLSMGEAWDNLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASAGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQQGRLLR
TNDALCRLLGRPASVMRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARLCER
PHSSPAATAIEALDAAYGDVESSLTHCYQADGYEGEAVPGGGPFDHHVHAEAPDPEHDDG
TKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLAD
GLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVE
KRSRSKVHRRAG
>A0A7U7GCI3|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MAALMLPDLKFQLDSAATPDHPPSEGQAQADIALENVLPTLTQILDLNPAATFILQAIPG
STDHAFQPLYLNPQFEHMTGYTAADWRQPGFWAAHVHPEDRPVALANQYRLQHQGQIEHE
YRFCHHDGHYLWVNDRLVAQYDAKGAISLLMGVWWDITGRKETEARLRLAASVFAEAHEG
ILITDIDANVVDVNAGFSMMTGYSREEILGRNPRFLRSGRQPPEFYVAMWQTLLDTGGWR
GEVWNRRKDGQAIIVLLNISAVKANDGMVTHYVGVLSDLTALRQSEQRLEHIAYYDPLTR
LPNRNLFTDRMYQALAQADRQNTLLAVCYLDLDGFKPVNDTLSHAAGDKLLIAVAERLNR
GVRGDDTVARMGGDEFAVLLGGLSSVEECENALTRLLRSLSRLHVFGDRSFEITASIGVT
LYPNDGGDTDALLRHADQAMYLAKQAGGNRYLMFDAEHDRRAHVHRAQLSRIDTALTTGE
FRLYYQPKVDLREGRVIGAEALVRWQHPERGLLPPSQFLPAIEGHPLLAKLDCWVLAEAL
NQMDRWQTQEGLPLTLSVNISATTLQQPDFPDRLAVRLAVHPQIAPAQLELEVLETAALN
DLNHTAQVLEQCARLGVSFALDDFGTGYSSLAYLRRLPVRTVKIDQSFVRDMLTDAEDMA
IVEGVISLAQAFQREVVAEGVETVLHGAVLLKMGCACVQGYGIARPMPPDALPDWVQNFD
PHPFQALSQSLPWLREDLPLLTVISDHQNWCEQIAAQLRGERCPTLPTPNHHRCHFDHWC
SGAGQRRYGNLAVFQAVERLHHQTHVLAQELLDLHRANSAVALARLPELHAARDELIAQL
QRLQQELQISHLSE
>A0A377GBI7|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MEFPGVTGEQIEQKLIVQSYKHYYILIIADFVATFLYAAIIWNNTTRKLPIIIWVLVMFI
FNHVLRGLFLFYYYRQNPTDSSFNSSFWKKYFILNNLQSGILWGFGGLLFIYVADPIHRM
AIFVYLVGLLAAPAAKLLTMHSAYVAFMLPIWVLLLFLSTSITPSLSVILFVAICLFLFT
LVYATNQLSQFLMKSIYLEVYSSNLLSDLRRSEERFRNTIENAPIGMAIVSPAGMCIHAN
RTLQEILGYSDDELRNKNMLEITYPDDLAMTKDAMNKLLSGELRISHMEKRYIRKDGNII
WGMVSSTLIRDEQGEPLNFIIQMKDVSDRVQNEEKMRQLNEKTMETLNELKLLEHDESLL
NKLNRSLQICITAEEAYPRINLIAQDLFPDLSGGLSIYNKTINQMETVVQWGKEQILPQM
FPTIDCFAIREATTHVVDDPHKTVPCSHYQSPPQGGYMALPLMVQNELIGVIHLTAAKDK
KLTQHQQDMANSFGNIVKLAIANINLRVSLSELSLHDPLTNLYNRRYLNDILSRELIRIA
REKKSLCVAMLDIDNFKIFNDTYSHLAGDELLKAIGKLLKDTFRESDISVRFGGEEFVVV
LLNTTLDKAMNKMEELREKIKSLTLYFKGSLLKNVTISIGVAEALKDGASIEEIIKAADH
ALYAAKKAGKDRVEAYSNNS
>A0A7U7G9J6|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MTLTSQHRLSRFSHHLWLTAGLFVALAIAFVLYVHSEKQIDRAHDLRHQSFLLADELRQS
SDDLTRMARSYVVTGNPVYQKYYQDILDIREGRQPRPQEYQSIYWDLVLADGQPPRPASP
QTIALLELMRQTGFTEQEFQKLADAKASSDALTATEREAMQLAQSTGPEAEADRAKARLM
LYGDRYHQAKATIMQPIAEFYRLMDQRTLDAVHTAETRATAFRFLLIGCGIAVLLMLWRV
YTALRGTLGGSVDAVYAQIAQIGDGDLSPAIPIKAELEHTVLGWLSATRAKLNRMDRERQ
QVAEALRVSETRVRMKLDSILSPNGDLGVLELADVLDIPAIQATMDEFFKLTHIGIGIID
LKGQVLVGTGWQDICVQFHRVQPQTCRNCVESDIALSRGVAPGTFKVYRCKNQMYDIATP
IMVGGQHLGNVFLGQFFFDDEPPNREQFRAQAQHYGFDEAEYLAALDRAPRWSREKVNTA
MTFYTQFAHLFSAVNYSNLQLARSVAERDDLLNALQDSEARFRRAMEEIPVPIMIHDEDD
RILQLSKGWTRYSGYTLADLPTLGDWTERAYGARTGSEKDYIDRLFLIDATMNNGEWIVT
AKDGSKRIWEFQTTPLGRIHQDKRVLLSLAVDITERKQAEAALRESNELLSLFLQHSPLF
TYIKVVTATESRVLKASENFQEMIGIPGSELVGKTMEDLFPAEFAAKITADDWAVVSSGQ
TLELNEHLNGRTYTTLKFPLALGGRSLLAGYTIDITERKQIEEALRVSLADVKRHDAQMI
VLNRMNDLLLSCETRAEAYEVIASSAGTLFAGCAGSLAMREATAPELRVVATWGDADALP
TTFPTHQCWALRRGELYEVADPAHRVHCQHFATPPQYAYWCIPLTVRGENLGLLHVSTAT
ALAGDALQEWRPLLMKVSGSIKLALSNLKLQEALREQAIHDVLTGLFNRRYLDETLPREL
RRCQRSGEPLAVAMLDLDHFKGFNDTYGHEAGDAILRTVGELLWRSLRAGDLACRYGGEE
LTLILPGATADQARTRLDGLRQAIMQLRLLYQGSELPAITVSIGIAVAGQWETNATALLG
RADAALYRAKESGRNRVMIAGA
>A0A142X1X8|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL14|TrEMBL
MNLPLPTSEAEVLPVSPITRTVVVWFLAATVVMCGLGLLIHRGVQHLLDEADQIAKTHEF
IALVNDTMSHVKDVQSAQRGYLLTGEREYLEPYHVALPVILRNLDRLREKAGGDPVLLDM
LAKWRTLIDDRVIVARNILETFREDGAEAAVAELRLGQGRAKMAEVRAMAAEIEAAQSNR
LAEGIATTAASTRITFLISVGGFIICLGILGGVFWVVRRETLRRTQTEEVLQQSHQELED
SLADLRRLTTETAVVTTMADFLQTCQSPKEAYAIIGRNIPRLLPGVSGSIGIISNSRNLV
EIVYSWGDDTTFSGDFHPDDCWGLRRGRLHNVSDTEGCEPLCGHLLTVPQGYLCLPMVAH
GETLGVLSITSTRSGGLTDEEQKAARTIAEQASLALANLRLQEALRVQSIRDPLTGLFNR
RYLEASLERELIRARRQDQSVAVVMIDIDHFKQFNDTHGHEGGDALLSNFGKLLSQTVRG
EDIPCRYGGEEFCLILPGANENVAVQRAETIREALKKMTVRYRQKPLGPVTLSAGVAVFP
EHSEFGDAILQAADMALYRAKKLGRDQVIVAGTEDVKPVAASVSPPAPNDLENVLLAVMG
PNGNACCHHEELTATTAE
>F5NVB8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A8B3W6D2|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MNKLSFDRKMPLYVVSTLALNMAVSLWLLSMASSAVMAFSVCALFLLSTLITARLYRHEM
AQSKNSLSEAIIDGVAGFIILDSQLRVIQVNQQFSRVSGYAFNQVESRPISDLCFMNNSS
LISTITRSLKENQRWKGELSGVSRLGEHFTVNVVVEKLVEILSHNNKYVVTFTDISRRKV
LERRLRMLVDTDSLTGCWNRRRFDKDLNHYSNLAERYGYTHSCLALIDLDHFKAINDNHG
HDQGDSALKEVAELLRNNSRDTDIVARVGGEEFAILMPETNLAEAFEAMYRLKEVISKGT
TLNLTVSSGVSEIQAQAEATYRSADKALYRAKGNGRNRVCSSSPGCATPIALG
>M7S629|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Dublin str. UC16|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377G9H4|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MLFNLGKEATLMLLEGTKNAIPFNIVFASLIVLIFLYNRVPISLTIGWYLGILLISMVRW
FFCRQNINNHLFKVNKKNLLIKFLLLTLSMGVAWGICYLISLTYVSVLYEFIIILVFGGL
SAGSIAFLSVYLPAYYAYVFPMFIPVIIYNYLVFNMGRTIFATMFILFILMLLLSAIMNK
KLLDKTFQLSQDKETLIYELQITSITDPLTGLYNRRHFEVLLPQELRRAKRNQYPLNLIS
IDIDNFKLINDNFGHPSGDKVLVSLGSLLTHICKRANDTIFRLGGDEFAAILVNQPLGEA
VHICHKINNLFKRNLLNDFNSKELAILNQVTLSMGIVNIHFNSSYNMETVINVADKALYQ
AKKNGKNQIVIEQIH
>A0A8B3WK10|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MEQQFLLEGHRAVNSLLRKLALGMDRKDLNHKIIQLTEQIFGQRMASILLLNSESKTLHL
EYAPNLPDFYNQQIEGVGIGTGIGSCGEAAALKKAVMVSNINAHPNWAPFLALTNQANLH
ACWSVPIISSRGHVLGTFAIYSQYISEPHEFELEILELLASLYSVALEKFELENQLNFFA
NRDSLTHCLNRRALFNEAEKVLAKRCFSEKVMACLFVDVDKFKSINDTYGHSFGDDVLLA
VAEVLDEATTACAKIGRYGGDEFVVFSCFDDQESVVSFYHSLEKALQQALYINDVQFSVS
VGLSCEKDPQGLDLLIAQADKNMYQIKQAKSQR
>A0A174XLW5|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEKNISANDFCRFIWKSYLEERRYDLISDFISDKISIIGTGAHEVERNLQEFIAKIEEES
QEWTGRFIIRDQWYQTTELSDSHSLVMGELAVREDADEGILYDMCFRFTIVLEKAECGWK
IVHIHQSVADPNQASDEFFPHHMVEQTYTQIVYNLRHDSLTGLLNRLYFKETCERFLTAG
DSGAFLMIDIDMFKNINDQYGHPAGDKTLISFSESLKSVIAPNALAGRVGGDEFTLFLPG
MNHKGEMEGFFTMLNTDWGERQKLLQMHEPVSISVGVTFTSKGNNSYGVLLNKADQALYL
AKTNKNDGLVHWEFLL
>A0A2D1IKP3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. LoGeW2-3|TrEMBL
MDNECMDMLAGQWQHICQHYSSDDLVHAFQFIQDNALVLVEEFYKNMLVEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHIVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDNQLLTLTTCSYLVQVMGFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMYKVFSGQENLRHPMLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQTILECQDKAQKLSLIQQIRELNREVQHLIDQLFQVAEYIESGNDTLTQLL
NRRYLNTIVSREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADALQKYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIENGMITTAQGIQFKFTVSIGCTI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDARVLNTPSLT
>A0A161GKB5|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MNSLREWWALPVDYGWNVAFARSQQALEITKILIGLWCWLFGAAAAIGLVVPGLAEGTLG
TAALWFTVATTIPVGVAWWVGGWPSWQMSIAFVFYADVVLAAVVLTIGVPTTVLPTAALF
TVIGSYVVGFHGPKLLTAHYGFALVTTAVLYGSALVAEPELRLLATVYLVILILVMFSAP
LIVHTFMMMLRRDATGAFYDPLTGLQNRRGFDAAIGNLRLRPGSATGMTAVVMDIDNFKA
VNDRYGHLQGDAVIRLAASRILDVFPAPAITVRLGGEEFAIIALDDRDSVVASAEVLRIR
LCNATDRSPLTASIGIAHAVVDTREIGTAVEELLGRADRAMYRAKGLGGDRVALSEGEPR
SPRPAGEPH
>A0A161GA58|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MRANDETPDPLLRTGVVVQTLLFGLLGIGTTFTQDGPTEGLGTVLTYAVCISTIPVARIM
SKAEFGMDWWSRRAPVNNWFVVYCELGVTVVTATYADPLAALQGAMLLALVGAYAAHFAR
PKVIWFHVVWSTVYMLVLGASALATTPTDTVSVVLRVVVAITVINGAVTLLSAFSRAVLH
SSRVHLSDAMTDPLTGVLNRRGLEARAVGAGNDPVRPALVLIDIDHFKAVNDHHGHSAGD
VALRLTAMRLTMSAGRHAAVSRLGGDEFVVLVPDPTPTLGEFAERLRQAVHNVADDIPIT
VSVGAALPQVDPRSTRTVFDRTLAAADEALYRAKRNGRNCVALARPPGDIVH
>A0A1G4XE86|diguanylate cyclase|EC 2.7.7.65|Kosakonia sacchari|TrEMBL
MENYLKLIKSEWTHLIDKTDDRIRFLAAEVGKTHAHILSQEFYRIVLTDPHAEEFLSNEQ
VERDLKSALEKWIIDVLTCQVADIDKVIAIQQHVASIHARIGISVEIVEMGFRVLKKILF
PVINSSAQEAADKLEVYHYAINSIDLAMEVMSRAFTFTEHNSAKEDENYRIFSLLENAEE
EKERQSAALLSWEIDLIYKIIMDADLGNSLSLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LIQDLDEVFRNTRNTPRALSNRTLRIKFLIQIRNTVSQIITMLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHAKRMNTPLSVLIIDVDKFKQINDTWGHHTGDEILRKVSNAF
YDNVRSSDYVFRYGGDEFVIILTEATEFDTLRIAERIRGRVEKTNVISPSGENIALSLSI
GAAMFSGHPDYERLIQAADEALYIAKNKGRNRVELWKAPD
>A0A5E4SP46|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MKRYLLSASPLTGRLRLQNLAIVFVVIVLCAGLLTLAWRSYQRASDADQAFDALRATLLA
MEKASAERGPANAVLGADLPLPQEAVSSLRAAREATNAQLDRLLYVLSSDHCESCGTSLR
AVEKARLDLAAASANVDLLVQRPRELRSDAAVRDAVSRMIRVIADFSPVASTRIDVVARG
APEALHYIILARLAADLREYAGQLGSQFTASLTTGQTLTEADQRAIERILGRIEQLREMI
TSRLSDPSALRPGIVAALNTQYFGAGLHYVATVRTLASQPKPAPFSTATFARQYVPTMRS
ITDFRDEMLNLAQAEVEARRTYALRLLIATAVIEITVVLLIYLVMRNFRRNVVYPLETAA
GVIDALAKGDPHMAPISEAPSMHRPEVRTMFKALRILQLSGIELMQLRRERARLVGELEM
LSDTDPLTRLLNWRAFERHARALCAMPAPGRVALIKFDIDNFTQINATWGHHIGDDLLRR
VSAVCLNTCQPGDVVGRLGADAFVVLARVLDESRAQQFAELLRGRIEASTLPLGDGAVLT
ITASFGIAMAKPATVDSAPAHEADAADGASSAVPDISALLSQAERELRAARQAGAAGHHS
ID
>A0A649YQE5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MIVRYKRFLSGFCVLSGLAILVTTISYQTNPESYSDLLFEANTLFVLLFIYFVSRELYRN
NTFIKWGLILLVVNQAYDILTEIPVLDQWTDNNEFTHTLIEDGGIQIAYLLIAFGVTRLF
RQMSEHAYTDELTGLFNRKKLFSIARKQFDLIYIDLDGLKQINDTQGHASGDLAIIRFAQ
AVNASVSPTDKAFRIGGDEFVIVVGPGEGEAFIDRIKKDLVEEQILFSYGIEASTPETLK
ENLIKTDKAMYEMKNSQRKGAESD
>A0A1H8EUW7|diguanylate cyclase|EC 2.7.7.65|Halomonas aquamarina|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVARILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVC
>A0A649YUC3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MRFCLILLAVFLTSLSHAHAKDKDVLIVHSYHPGFFWTDAFQYGLEDILRGESITTRVVY
LDSKRLQNPAYLEQLYKLYQTKFSQETFSAIVVSDNNALNLMQRLAPEIGETPVIFGGIN
NYNPQMHSQLRATGVVEDIDIYSNVTLIERVQPEVETIYILSDHSVTGEAVRRQVEQFLT
LNTEYQTMVEQLAPETYQQLIEFTSSLDKSSAVLFWVYYRDKNGRVATEDEWEQLNQESK
SPIYMVHDLGLGHGAVGGVILSGRTQGQQAAQQLLKVLNSTSKTLPKVEAGIPEIKLDYQ
AVVRWGLGIEGEAISTLFNKPQPFTVRFQKELRAVASLVVLLSVIIVVLVYYLSRMKKSE
TLAKESQTLIEMVFDQSYHFIGLLDAQGRTVSSNSKLQELFYHQDFSVDRPIWQHQHWED
QAAQQLKSYFNTDKSEQNTQFEAEIWHSEQGSIVLEISLKPLPKTGQGADFLLEARDITS
RKITEARLYQREANLSHYYDQQPVMMITLDDHNCIQQVNHFAEQLLGYTSNQVLGHSLGE
FYSHQDAVTPRQVLLQPKQAMRGVWRREIEYRHADGRAVWVRENIRPLVESGHLLIVGED
ITETKKLAEQLEYQARHDLLTGTFNRNHFEMELAKSLLEVESYTRTHAMLYLDLDQLKVL
NDTAGHEAGDTAIQFCASMLEEVLPYNAILARMGGDEFAVLLKDCTERDAKNVANTIVMT
LSEQPFVWDDIRLNMTCSIGIRLIDHTADSPQMVHAQADTACHAAKEEGRNRYNLYCQDD
ADLQRREQEMECVSLVHNALANDRIELFAQQILALSQDDAPMHFEILIRIRNAEGEYISP
GIFMPASERYNIAQLLDKQVVTQTLDWLAANPEALANLGMCSINLSGHSMGNKEFIAFLL
DTLQHSPVPCEKICLEITETAAMSNMNQAIELFSQFKRLGCKIALDDFGSGLSSFGYLKK
LPVDIVKIDGLFVRDIDVNEVDHLMVRSINDLAKQMGKQTVAEFVENSRIIDLLVELGVD
YAQGYVIGKPKPLEELVDELLTDKRSVG
>A0A6N8HJP2|diguanylate cyclase|EC 2.7.7.65|Lentibacillus sp. JNUCC-1|TrEMBL
MIGLIIKDLFTNLAIIVAMLFLYTQFINKHPLNRQSAFREKVIAGFLGGLLGFVLMFFSM
NIDTTIIDLRHIPVVLMSYYGGPVPALTAAFVIIAGRLLIGFNLSSVFGILFILLTTGFS
IFIMKQHLAKKFKLLSIMTFSNIIFTSLVAILIKPTDLVIIIPAFWLISYLAGFIAFYVA
EFLLNSHILYTKYMNEAKIDGLTGLNNHRSFDHTFNQLIEHANEKHPISLLYIDIDFFKQ
VNDTYGHSEGDLVLQELGMILARSVRSTDIVSRKGGEEFTIILTECPLAYAQDIAESIRQ
AVEAEPFLLSSGTKIYLTVSIGVATFPETTQNAYHLIEDADHALYNAKQTGRNKVSSIDT
VHNTKETQR
>A0A8H9I5M4|diguanylate cyclase|EC 2.7.7.65|Halomonas hamiltonii|TrEMBL
MRYKDKHQLAAEWLTLLERTPVALRQAVEQLAHAHQAPFAEHFYRVMLDDPHASLFLSNE
QVEKRLHPSMQRWLSAMFAVEHADLEALVEHQEKIGQIHARIDIPVNLVLSGARQLKQVF
YEQINRSIHAPLSAGEAAVYVSDHIDMAMEIMSHAYSVANNRHARTEEAYKLFSLTQSIG
DERERQRAALLNWENALMFAVAAQQETSALPRLASSEFGLWYLHKACHAFEGAPEIAVIS
RHIHLVDDQWMAQLTDGDSALRLAALSHIRDAARTILMLLDDILDRASGLEAGRDSLTRL
LNRKFLSVVLNREIELARRSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDPDGSRLFAERLRQAVAKEPMLATADTLLSVTVSVGLT
LHDGHPDYQYSMQRADQALYQAKRSGRNRVVCVN
>A0A6V8ILX9|diguanylate cyclase|EC 2.7.7.65|Gluconobacter sp. Gdi|TrEMBL
MTTDASEVQEPSIAEQEWQGLISQTPAPVQEIVAGVIDQHAVDCVQRFYEVLLNNADAAP
FLSNEIVDTRLRAALGRWLAELFSHDAPDASILVQTQQKIGAAHARIQIPIHVVMHGARL
LKRKLRVFIQALGLDGPQYSAAIAYAEDMIDIAIEVMSLAFVQGTRKEVEVNEAFRLMSL
GKDISLERETQRAALLEWGQSFLLDICYGGDSANTLSDSAFGLWLRHKGSVLFQGASEID
VVSKAVEHVDNALVPKLVSARPVPPQAIKALQGALEEIHYMMDQLFKTAEAVENGRDPLT
KTLSRRFLPTILGREVSLSLRRHIPFSILMVDIDHFKSVNDKLGHVVGDSVLRYVAKILV
AQCRMSDFIFRYGGEEFLVLLTETQEEQAIQIAERIRTAIEQNTALTVNEIDIRVTASFG
IATFAGHPDYRHLIEDADRALYLAKAAGRNRWHVSKGRHVHSDGLAE
>A0A5C6DEB5|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MLASFEPFSEFRVTAQHILEYLHEQLGFSLWMVTRTEGDDWIVLQAEDHGYGVKEGDVFL
WTDSFCSQMVQGKGPCVAPDAKQVPAYATAPIGQQVPIAAYIGLPLTKPDGTLFGTLCAI
DPQVQPDTIKSQLPQLTLLSRLLGTVLASELKAEAETRRAERAEAEAETDALTHLYNRRG
WDRLLDAEEARCHRYGHVASVLLVDLDNFKTINDEQGHDVGDLMLQNAAAALSEGTRDCD
VVARLGGDEFAVLAVHCDQSMAVELKERIQDNLSKVNLHASIGMAVRNPAQSLEHASIQA
DKHMYACKRAKQTEPIARSSKATMSSNRRNAQFA
>G7ZBS0|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MNFDTTFIAQVITVIGFAVGLSIVVAAGRYPRHIRNSLRSYAYGKFLLGSAFLIAGLRGG
GTPELFIPLANGIGLAGLTLNYTCVRHLQNRPVWPFGPAAVGGGVALCCLLLLLAGGDLS
TVRTLVSFAASAVLLVIAFEVLVRYDHRGVPHYVTGLLSAALAVVYLVRMGAGLSQEAPL
GQLVDDTVERATFLLSLLGTVIGAINYVLMASDEFNRELTKLAHTDGLTGALNRRRLFEL
GEIEFRRARRQGGDLTLLTLDIDRFKTINDRAGHPFGDRVIQAVTECCVGQIRQEDSIGR
MGGEEFAILLPETGAEAGRMLAERLRSAIERQLAPLGAQGGVTVTCSIGGVSMTREHSQF
SDLIAQSDSALYDAKNAGRNQVRFFQAPALRAAATA
>G7Z725|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MIGPVMNPAAGPLGPRRPQSSRDRDRFVGFAFAAADLLIETDAQGNVLFSAGARCRLTKG
EVGGLVGTNLMEVVAPGDRKYVHVLFERIREKARIKPSRVLFQAFDGQQFPALLGGCRLD
SCPGSLFLTILLTVPPRTGSAGSAVQGELLDQTGFANILEERLLAAREKGVDQGLTLLLV
EGLQAMVDAMPEGAAAEVRDGIDAYLRGISADGDSAGQLGGDRYGIVHAADIDGQEVQGH
IAQIIEAAGGALPGGIRSWTLDMADDRLDPADAARALVYTVQAFASAQGGEFTISSLEDG
ANRLMAGAVERIGQLRATIDNRDFIVVYQPIVDIATGAVHHLEALTRVEGSNSPADFITF
AEDVGLIYDFDLLLTQTVLDTLKEFRKEPKLPDVAINLSAKTLMSPIFLKQFQSVVAPYG
DLAAKLLIEVTETVVVTDIAKLNEVLQKLRGVGFRICLDDVGAGSTSFQSLYGIQADYAK
IDGKFVRGAVNSPRDMAMLRSMVDVCRQLGLELIGEQVEEPVHSDLLTNLGVSLAQGFLF
SRPSRDFSYFAKDWSKVRSGGKILLKG
>A0A1M7YPG1|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MSPMQINSPWFRLITPVVVVLAVWVGIEKRFLLLPFHDSVLVNLPYVLFAVSVIIAQIFK
QSRMGMLAVSQLLCYAIIQFRLQVPLSIGSAKLELSLLSFLFPVTCMLNYAFRNAAVLTK
NFLLYILILVLFFAWAVLIINHTSQGGFDDISSGLLASVPQFSRLPFVIVLYLFAITGIT
AILLLNKNKALDAITYTSILLNANIFIFFHVPSISTLLASVSGVFLILYLISAGQEMAFN
DRLTSLPARRALEFDMRHLGRHFAIAMLDVDHFKKFNDTYGHDTGDDVLKLVASRMLHVK
GRAKAYRYGGEEFTIIFKGKDAEEAYKYLDILRQDIQDYKMSIRDSSGRPENSKQGLLKR
RNSDKKPKPDKTVNVTISIGVSDSNSSKVPDEILKLADQALYKAKKAGRNRVKIVK
>A0A1V5JZF9|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin520|TrEMBL
MRYPHAKLRHLEERVAFLSEELYAAMEALDMALGLGAFPATIVTLRDRDAVLRETEEKIR
TLMPFKATAFYLVDEGDASFSLVRCYPEEWREFFERERPPLVEDRTIAWALGRRRGVVVG
ATDGLEQILIHSLATPTGVMGFFLGVLGMKKHEIPDLAMDFLSLTLLSCAGVLESFALNE
HIHRLNATLQSHVASLQSSEGELCRYRDQLEEQVRERTGELARANDDLRQEIAERRRAEG
ELREVLDRYDRLTATAHEAVFRMAFSPDQTSRVVYLNPAAERMLGYSLAEWQEDSLLSEK
VFDAESLKKVNALIDRARWGEEGIPSEVIHWRPRDGRSLIVDYSVLPEVDHQGKVLGCEV
IARDITERMMLEARFRYQATHDALTGLPSRMLFSDRLALALAHARRNRSMVGLLFLDLDQ
FKHVNDTLGHDVGDLLLKAVAERLKGEVREMDTVARMGGDEFTVVLPDLGHPDAAGAVAE
RILEELKRPFVIQDKEIHIGASIGIALYPAHGATVKDLMKRADMAMYAAKGAGRGTFRFW
REAPPSQRSEAGGIY
>A0A8F8H085|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5E1ATI8|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MRIATITNWAYGATVCLTLASGIIMLMASNADTLERQAVEQRQKFDALTEDIETDIWAQS
DLARLYVIKKDPQILREYNQSENKLKSTELRLEKLQDVGASDDELSLLHEGIKIVDALQD
EQQVALTHTAQGEDAQAIALLYGAPYEQELERAQNQIDHFRQILDKRVIASVQEATKKSK
TLRTVSEMMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFADVINVAELFAP
NIAPGIAGRLYILDRDPWQMRCVAQWLSPPGEDTPFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPASHTHTSLCVPMIAQGEAIGLLSFQNITAENAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQMAQAVRNEEPVSCLMIDIDHFKSINDRFGHEA
GDQVIKSVATIIQRAVHDSGLAFRYGGEEFLVLLSGVDEEAAQACAKEIYNGVHELSLRY
GLSEIGPVDVSIGVASYPQHAQSDNLLRAADVALYWAKELGRSRIVSFGMLEAG
>A0A7W4V972|diguanylate cyclase|EC 2.7.7.65|Cupriavidus alkaliphilus|TrEMBL
MQPESSNPTAVPAPAPATDKQEYLAMVLLVDDQAMVGEAVRRALASEPDIDFHYCSQPDE
AVAVAQRTKPTVILQDLVMPGVDGLTLVQRYRDNPATRDIPIIVLSTKEEAATKGAAFAA
GANDYLVKLPDSIELIARIRYHSRSYVNQLQRDEAYRALRQSQQQLLETNLELQRLTNSD
GLTGLSNRRYFDEYLGAEWRRALREQTELALLMIDVDAFKAYNDTYGHVAGDEVLRRVAT
VIRDNCARATDLPARFGGEEFAMVLPATSPGGARLLAEKVRRAVQGLAIAHSGSPTLDCV
TVSIGGAVLVPQPGTQPGQLVEAADAGLYQAKRNGRNQVTMSPG
>A0A8F8DJK6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2J0PR07|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MQRDTFVVKQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALLTPLGFDVLHDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A4P6LXC2|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MELSDMHYSKKRKYRYPAKSRRIWIMISVLLVSCCILDLIYYKKVQDGLLEQTYSDLKKE
SNIARGNLESRLQAKQEWLEMIAAFCDIPDGSGTENWWDKTRQFCSEDYRLEMGDTQGNI
YYGDHQSGYVGDKPYYREIIAGKRSISGIQSMGYQDQDSIVVGVPIFRDGKVEGAVCAEY
TVSSLGNLINGSEMSQYGANLVFTPEGKLAASYSGMEHFETVYEMLETMEYKKQGEVRQF
RKSIEAGESGYLIYYNEGKMRLLYYQPVGIRDWAIATLVVTDSYEKIFNDLRSMSIVILL
ATTVLITAAAILTAYALKVRRKEIEKVKKDALTGVFTREAALQMIQKEFGKKDGGNYRVC
MFLDIDHFKEINDTYGHDAGDRVLIESGAILKRCLRNTDIVSRYGGDEFCIWVYGEADST
VLVNIANRILGEFRKIGSVSVSIGIAAAKQKESDYLEVLKRADQALYKAKRQGRNQYVLD
YSKEET
>A0A5Q2K616|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MINDEIFYTKESVQEEWHQDLFQDDSHHSGILFARRVRLARTVGLAAMFFPIAGVLVSHF
LPGGWWLLLVGWAFIWPHLAWQLAFRSAAPYRREVYNLKVDAIIAGVWIGLMGIGALPSA
ALFMMIGMNMMGAGGFRLFLTGTILAVLSALITLHLTGNIITFAPGGLEWGLTLPVLILY
PMLFAWVSHQTAIRLAEHKRRLELMSSRDGMTGVYNRRHWENLLRNEYEQCRRSHREATI
LLIDIDHFKSINDTWGHDVGDEAIIAITRQLQMSLRAGDFIGRFGGDEFAVIMSGTPAES
AIAAMSRVHERLNHMTLPRAPGVRLRISVGVAPWRTQFGHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A1V5JXL8|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin520|TrEMBL
MGLAIIEEEMRRGVLADPLTGALSRVQFMEAAEREFLRARRHGAPLALLLMDLDHFKQIN
RRFGRAVGDGVLRHVGTLWRRCMRGEDVMGRLDGEEFAVLLPETDLAGALTMGERLRHLV
ESCPPDKEALGVSEGDGLPGDEGLSVTVSVGVAVFRDGDPSFRAVMGRGDRALGRAMRQG
MNRVESYGD
>A0A554WZ82|diguanylate cyclase|EC 2.7.7.65|Tepidimonas taiwanensis|TrEMBL
MRWLLRAVLLGALVGSAVAQPVDLPASTASLSAQALFERHAAPMLWIDPDSGHILDANAA
AARFYGWSVPLLRQMRIQDINVLDVERVQAERQRAALEERAFFIFPHRLADGSVHLVAVH
STPYTVDGLTRQLSIIQDLSGPSTTAHETWRAHENMAQALAVQRAQLEATHRRRLLLGGA
LLTLTAITAALLGALLWRQRRLTHAAEQAEAAERAQHAALQQAHHQLQRLSTLAMALRGG
ATGTWEWDLRRDELQLNAAALQSLGHNAATLPRLDTPAWLALLHPQDRTRFEHAWAAHLA
GNAELLSCEVRLRHRDGHWVWVLLRGQISERDAAGHAARLVGVWLDVSQQRHEQETQALA
EQVFRHTQDAIVVTDPEGRIVRVNEAFCRLTGYATDEVLGRTPALLASGRHDRAFFAAMW
HSLRNDGFWSGDVWNRRRDGSLMANWMSISALRSADGALLGYVGIFHDVTARRLGEEHLQ
RAALYDPLTGLGNRVLLIDRLQQAIAQAQRHGHVLAVVMLDLDGFKAVNDTYGHAAGDRL
LVTLAQRFRALIREGDTAARLGGDEFVFLLPDLIRPADALPTVQRLLQAASTPVEDAAGA
LRVSASIGIAYFPQDGAPGPDALLQRADEAMYAAKHGGRNRYAEWPPDEATRSNTSLAGS
AGANSQP
>A0A6M1SAW1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWLTLLERTPVALRQAVEQLAHARRAPFAEHFYRVMLDDPHASLFLSNE
QVEKRLHPSMQRWLSAMFAVEHADLEALVEHQEKIGQIHARIDIPINLVLSGARQLKQVF
YEQINRSIQAPLSAGEAAVYVSDHIDMAMEIMSHAYSVANNRHARTEEAYKLFSLTQSIG
DERERQRAALLNWENALMFAVAAQQETSALPRLASSEFGLWYLHKACHTFEGAPEIAVIS
RHIHLVDDQWMAQLTDGDSALRLAALSHIRDAARTILMLLDDILDRASGLDAGRDSLTRL
LNRKFLSVVLNREIELARRSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIILVDTDPDGSRLFAERLRQAVAKEPMLAAADTLLSVTVSVGLT
LHDGHPDYQHSMQRADQALYQAKRSGRNRVVVQ
>A0A5B8QSW0|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MSADTIPNVAISQFPATILVVDNQPINIQIVFQVLGNEYNILMATSGQQAIKVCHDSLPD
LILLDVVMPKQDGLETCRQLKADKQLADIPVIFVTGLQHQTDEDACWDAGGVDFIQKPFN
TNTLRNRVKAHLALKRQADLLRSLAYLDGLTGIYNRRYFDNVLSIQLAQHRRKLSPLAVL
MIDIDYFKKYNDTFGHLAGDDALRKVASALKHSMREADMVARYGGEEFVVLLADTDINGA
VTVAKKILHHVLELDIAHPQTPATKLSISVGIAVADEAKGYDSNIIELADQQLYLSKQRG
RNTYSVVLA
>A0A0B8YGF0|diguanylate cyclase|EC 2.7.7.65|Pedobacter glucosidilyticus|TrEMBL
MSYLKDELYQLIKEDSSIFDFLQDAALDGLWYWDLENPDNEWMNPKFWATLGYKAEEMPH
SPSSWQNIIHPDDLKLAIENIQKHCENPETNFDVIVRYFHKNGSTVWVKCRGMAIRDKDG
KAKRLLGAHTDITELKIKEELLERCNIAASVGFWEIDLQIMQPKWSHVTKLIHEVAEDYI
PDVRSAFNFFKEEDKILIETAFTKALETGTPYDLELQIITAKGNLKWVRAIGLSEFKDGV
CTRLYGTFQDIEERKSLELALIAEREKLSNILIGTNAGTWEWNIQTGETIFNERWANIIG
YTLEELQPISIETWVKYTHPEDLKISNNKINDCCEKKSEYYHCECRMRHKDGHWVWVLDR
GKITSWTADGKPLMMFGTHTDITEQKIAFERSQQFIEQAPSAIAMFDTNLHYLAASNKWI
DDYKLNGLDIIGKSHYEIFPEIGEDWKKIHQECLKGKSQKCEEDKFVRQDGTVQWIKWGV
RPWYIDKNTIGGVVMYTDDITERKKAQEQLGISEQAFRGNFENAAIGMALLDRDGKWLKI
NKTLHDMLGYDEEELQHLTFRDITHPDDLDIDVSLYLDLLHGKINHYQLGKRYIHKNGSI
VNIILAASVVKDSHDEILYFITQIIDITALKNAEKEIQALLDVTKDQNKRLKNFAHIVSH
NLRSHSSNIEMLIYLLFKEHPELEENNILQLVKTASDNLKGTISHLNEVVQMNLETSSNL
VEINLYHFAEAAINNLNLLASDAQVKIINNINPKDEVKGISAYIDSILLNFLTNAIKYAA
SERESFVELKTYQKEQYLVLTITDNGMGIDLKTQGSKLFGMYQTFHGNTDARGIGLFITK
NQVETIGGKIEVQSEVNKGTTFKVYLLNAQNKYLNFKAFYLSKHKKIDDA
>A0A679JLF0|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MKAKPGVVPPTDHPPVVGDAFSLYDTEEAVLGKTDGMLAGLAQVAGGVQQLAEAYRRSYR
EQRRLVRMSDRMQLDLQKANHRLAEQQRDLQALNEALSGEIEHRTRLEAKLRHLADTDDL
TGAVSRRRFMEISQREWLRYERDRIPACLLMADLDRFKRLNDEFGHAAGDAALASFVETC
RRRLRKVDVIGRMGGEEFAILLTEIGADAGLTVAEDICRLVGETGVAWPGGPLALSVSIG
IAAIEGTETFEQTLGRADAALYAAKHAGRGCVRPSRGPSADGPPP
>A0A679JJY3|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MSHGSYGDRERTFALADRANVLMRDYGSSATPQAYAVWYTYVSGAQPPMNDAIKRLTTEN
GSLSDADIDSLYETYIDSRRLVAATERMNANMLAEIEGIMEVMDLSLGSTAQYGESLQAL
SHDLDVSGQNRARVREIITTLVSTTREITASNRTLEARMRESRNEIETLRETLEATRLES
LTDPLTGLSNRKHFEESLRKMVDGAASQAIPSSLIVIDVDFFKRFNDVYGHLTGDQVLRL
VAIVMREHLKARVTLARFGGEEFGILLPETNRAAAVAIGEKVRASVMGRELVKRTTGESL
GKVTISLGVATSRPGDTAVSLLERADQCMFMAKRDGRNRTVDDSRVALETLTAVA
>A0A380HQ56|diguanylate cyclase|EC 2.7.7.65|Staphylococcus saprophyticus|TrEMBL
MFEAIIYNISVTVAGIYLFHRLQYSENRIMVFSKEYVTVLMTIVALLLSAYPVPIFNEYT
LYLSFVPILFLGRYTNMFYTVLSAFIVGLVNVLIGDYTIITAMIFIVIAGIIGAIGPFLK
QSDIISLQILNVIALVIFAILSLISPYYEITEVLFLIPISFVLTITSSITFVDIWHFFSL
VNRYENEDKVDYLTGLGNVKEFDRHLNETARLSEENNQSLGLLLIDIDGFKDVNDMYSHK
SGDAVLRQVAQLLKNYVPQQFSIYRNGGEEFSIVLYDYTLDQCVKLSESIRGGVEQSTFH
LPNKEVIKLSVSIGVGYLTTDDYKSQRKVFKIADDMLHMAKNEGRNQVMFNPIVKL
>A0A2H6IR79|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MKKEEDKKIAAINAIKFNTKMYNLTALVVVFTLMLIIVNSVTSLVNYIPKYSIIALLSIV
SVLVVINYYLSKKVALNSIEHMQDYEKEVNKLLIAMEKEMDTQKLKQEQLEAMSLKDELT
GLHNRHGFMPLAKQYLKTLKRDKSIAYIFYADIDNMKRINDTYGHHEGDSVIKTVSDILQ
DLYSGSDLIARIGNDEFVILTVGSTESGVELINSRLQKKFDEANSAAGKEYTISISYGVA
KYNPEGPCSIEDLLTRSEKSMHEQKKGKQNT
>A0A4R0EBE7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4779|TrEMBL
MNTESIAMLAEQWKSICAGYSTTDLNDTFQFIQTHSLVLVDEFYKNIMQEKEASYFLSDN
LVQNRLKATLNQWLLDCFNVPFQQNFEEISKKQLVVGTVHARIGIPSWLIMRGVREIENK
VFNLQSCKVQENSFVIINYIIQVLGFASEIMCRSYEVNIEKSNDIKHTYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSDKVDFKHPLLSKSEFGLWFIHKAAYAFTGSEQVDVIIE
RIYEIDQLNENVLACVEKDKTIELIQHIREKNREIQHLVEQIFQVAEYIDSGNDSLTQLL
NRRYLNTIISREINFSRKNNVPLSLLAIDADYFKRINDKYGHAAGDLALQFIGEVLLESV
RGSDYAFRAGGEEFLLLLVDSDLTRAQEIAENIRTRVQETPIRTAAGSSFNFTVSIGCSL
YDGHPDYQRFLDAADSALYAAKNNGRNNVYLGK
>A0A8F9HD83|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8F9HEX5|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376ENZ1|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MILVVLTFNHMREVCNNAIESVTEILLREQAVNDSIASMISTSTMSHMNTKCESKELLGA
LYTNRNFDTQSCSKINAVIFVENYLSKKTLQNRYYSSPEYGFVYFFNGKKYKKFQPGMYS
QVISLTGNFARFLSYEKRKRDILDFWDNHLEFNEIYRDSVSKNLVMTIATPVTNSYTREV
IGVMYTDISEDELQQHVFSRSPAPKWVSVTANNISYDRPGSLCATQHCDTHALSFKILSQ
PLAEIFILEAKVDLYAFIKENIKIFLAVLIAFIVIVTAAIKAINLFLKTQKHAVIDSLTQ
VYNRQIISHLSGKDYNSLVIFDCDEFKVINDTHGHLVGDAALTHIASIISDNVRNEDVVV
RYGGDEFIVLCTNEKIHARKMAERICSKLKVNPLVCGDLTLPLSISFGVAEFTDDLHTAL
YKADKALYAQKLKSRSQKVDATN
>A0A376E2N7|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MDMTANNWRALTEEKYQLSLKLFLFLNLFSALFNLVDPLYDYPHIPWPALCLIALCGSLL
LHVRTRVFSLKAINLTALLTGALWSINIWLKSPWCVFHDGTCLLITLLGALFIAALSFIN
MPGPSIAFCLPVTATILWLDNARHPVLYAYTIILPLMGLVIRHFIARRNDISARKLMQKL
TDEKATLNDLSMMDPLTGLCNRRGFQNRFDNLAPDAGQLFVLLMDIDHFKAYNDHYGHMM
GDQALTRVSAAIRDAVRSRDIVTRYGGEEFMVLLTQADEESARLTAERIRQRVYDLRIPH
IFNESVATNVTLSIGIAPLENGDIDDALRRADEALYAAKDKGRNHILYHDARRAA
>K9NJG1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MKRDTHLVVLLLLFIGCSLASLTVWKVLASRDRALEDVNVHGLNLTQALATYSEGIVRQS
SLLLLGLVERLETEGSGPIQIRRLSALVNRQQPLMPQLSGISIYDNQGRWLMSSNRPIPA
GANSSDRAYFIHHRDDPSREILIGPPIQSRSNQEWVITVSRRFNDARGEFAGVVAVTLGI
ENFLRLFGKIDVGQEGAIGLSYTDGTLLARYPFREQDMGRNFSKSPIYAKYLVDRSVGTA
SFTSSLDGVERLYAFQKSDKLPLITTVALGKREALTAWRMEALLSAVVVTGLLGLTGLIG
RLLILDIRRRTKVEGQLRGTQEQLLSSNRQLELLAMKDALTGLANRRYFDVTLAMEARRA
QREGTSLALLMIDIDYFKLFNDSKGHVAGDFCLQSVGKVVEECVRRPSDLVARYGGEEMG
VIMPDTDIDGAQVVAQLILRRLKEESISHEASPLGRVSVSIGIATAAGSRLNQLQSLIEA
ADQALYSAKTLGRNQFATHCKG
>A0A399EMV0|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MLRYPHRQAMNPSPVDPSALEASRRRTGLLLLPLAAMATATAWLMSYANHSLNPVDRWLL
PLLTLEALLLWGLLYLRRLSVREVEMGTVVGLGAYQLAMQVYLVISGEVYRDGFGATSLW
YPLMFPLIFLILPREQALRFSVTYYLLGLTIGLVGLALGASPSLKALNSFVQFYVVCVVY
LVLLDIYARVREQYFLMRQMAHTDPLTGLANRRAGRECLEHTLNRAAPGSAAVILADLDH
FKAVNDRYGHSVGDQVLREVAFRLDQELREGDLLARWGGEEFLILVQGADLEQAQRLAQR
LGAAVQEQPVAGGIGISLSFGVAVFRPGDSVETLLERADQALYRAKHLGRRRVELEA
>A0A375CYJ0|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLSALLDRLWEQAVRTPQRFVVLSFAAACALLLIISAHGLVVLRDHEVQTLQQTQQL
QVAGISSVLNVESERLRGVRNFAQHLIRLQMGPHAVEADPPLQAVYAHRNDDLWQLPAPE
GDAVLLGVGPRMLEGLDGFSRRDEDLLPGLYVARGLSHLLSAEPVNPLVTRKLMYVSTNG
FFVTYPPVPPARTAAVLRRVNDAGLMREHLPRNNPDRTLHWQMVPVGGDSGMYLTLSLPV
YLHAQFRGVAISAISQRSLDDYLTSTTRKGVHSFLIDIDGHLIGASTREVKGVEKIDSVV
PPAGREATPREMFSRGAGTIHLPDGSRLMFERIGGSNLMLVDYFSATDLLLRTASHLSAV
LAASALSLALLLWVTLQGFRKLFSHYLARGEALRELAETDPLTGLSNRRMFEARFAIEHN
HSLREKTPMSMMMVDIDRFKRINDNWGHASGDRVLKKLADVVRATVRSIDVPARIGGEEF
AVLLPRTSIAEATEAAERLRQVLGQVVCEPAADATDKGEIRFTVSIGVSDLGADGTDSLD
TMLMVADRRLYAAKNAGRNRVVSDDPVPEPMDDGTPAPARTA
>A0A8I2BUS6|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MGRGGTQAHTSCVRSTCVRRIGHAWLWLLLCCAMLNAWPADAQVLKHSAYHTVTRWNMDD
GLPHNLVHAVAQGEDGLIWLGTWEGVARFNGRDFTVYDRQNTPGVELGGVFVVVRDSTGG
MLFGTAFDGVYHYQDGHWQQLGDASARHLAVSALLRRADGALWVGTPQTLYRIEGDGRVV
DVGRQTGLPRARVTALSADESGDLWVGTEVGLYRLPHDGVQAAAWGRAHGMRDAPVRRLA
SDRQGGLLVAGDDGVWWWSRGGGLQRFRQGQRVDSVLLDRRGHLWMSLSSGMLVVHSGPN
DPDEQIAISGVASPALLEDAEGLIWVGSTHGLFRIAEGAAHGVTHDEGLSSDYVRCVLQT
GEGTVWVGNAVGLDRWRDGTISRVSLSPSEGGRVLEQSVLALADAGDGGVWAGTYSQGVV
RLDAQGHVLVRIGAADGLSSMSVRAVLPDGDDLWIGTTAGLVRWRNGKARRYTAADGVPD
GSVQVLYRDAQGIVWIGTDRGVTALSPDGSTRAWLGEQDFPGQNAFDFLRDAAGDMWIAS
DRGLLRLRGDRFRVYDHRVGLPRDKVFRVIDDGHGYFWLSSNHGVFRIARDNFDQLDAGT
REQLSVEVVDRSDGMPSNQGNGSSAPAGWLTQSGQLLFPTAAGLGVIDPARVGTLQGHRV
PIVFERLLVDGMVQPLSGPHRFGAETRRIAIVYAGLNFRGPDKVRYRYRLEGFDPEWVDA
DNASEAVYTNLPPGRFRFRVQAMSLPVDWRQDDLLGEASLVIELAPPWWRRGEVIGLGIL
GLASVIYGLYLWRTASYRLRQRQLNTVIDRRTRELSDKNLALQQASQEREALMRQLEYRA
SHDVLTALPNRREAERVLQHWFDEAHAGGAALALALMDIDHFKRINDDYGHEVGDAVLSA
IGEVLGEQEQAHCFAARHGGEEFLLAATGLDAAQARALFERMRQRLADIQVDAQGMTVRC
TASMGMAMSEEAPSRRELLALADHRLYEAKRQGRNRLIGP
>A0A378J8Q5|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MVFPAIMIVVGIVFLIGGAYLIKSVLQQTSHYRWQWLVYLVFIGAFILSYSASIFYGLLV
DPHCLNYFYGSVFLLGATYVYLSCRLMTKTIQKMEVMDDLKNRYELLRHHVKYDSLTGCH
NRETLFEMLNTRFQQIKSSDGWVIVLFIDMDKFKAVNDRYGHDVGDNTLAAFGQLLRQRL
RKDDIVARYGGDEFIAVMEHISLDEAKKIAENLITVAKQSFKKGILSKLNLGCSIGITQM
NPHSASVNSVIKEADLACYAAKQRKINGSVCVYNPMLATRNDTIDLGIHQIAE
>A0A8I1XVY3|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. PvR133|TrEMBL
MNGLMLGLFGILLMMTGLWIRGHFVVDLRQLAIIISVYMGGSVSGLLTTLIISLYRIYII
GGWTDVSLTATVNCFMTLGISLIFIREKSLTLRKWMSAVLGAAVVSLLSTFYVVNPPDNE
SMIIITTVKLLGGLFTYFMMSHIKKTERAVHLLEEAANRDHLTGLYSPRAFDALFEEVFH
TSKTTKQPFGLVMLDIDHFKNINDTYGHLNGDTVLSQLGMLLIRESTTRAYPSRKGGEEF
AILIGNCDSQKAASFAEKIRKAVENERFLLNDGTSISLTVSIGAGSSPVIASRHLLEKSD
EALYEAKRSGRNQVKLAKP
>A0A8I1XKU0|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MSLLDTYRRLAPGGRRPRVLVVDDQPVNIHALNELLREDCDVSMALDGQRALQLCREQLP
DLVVLDVVMPELDGLQVCRRLKADPATADIPVIFVTGQDTPEEEVTALQAGAADFISKPM
QPVVVRARVQNQLVMKLQSDLLRAMASLDGLTGVANRRRFDEALQLAWKNCQRENRPCGV
LMIDVDHFKRYNDHYGHLSGDACLREVAQRLAGCLARPLDLLARYGGEEFVALLPDSNSD
GVREVARLMLQGITQLRLPHADSPIGPWLSVSIGGASVLPTPALLPATVLAHADTQLYQA
KQEGRVRACVA
>A0A3S4GWJ9|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MNARSYQELLASKHRLSLFLFLLMNAASSLFTILVPFQDKPAFTLPLLAIPLFCLVALLF
TLHSMQQLIKKLNLFACVIGLLWAAHIYIKSQYLAPNNQSFLLISLFSMFFISAIALTDN
FIAFCLHAVPSALVILLLDGKHNTVRIVFTTVLPIFAFSIHHLMLKRSEAFTQRLVANLY
NERDRFSNLSMIDPLTGLYNRRGLENKINMLPESQSGRHFVLLLDIDHFKAYNDNYGHTM
GDQALVQVAIAIRDSVRSRDIVVRYGGEEFLVLLTNVREDYAAQLAERVRQRVQELKIPH
RFNQLEETTVTLSAGIAMLDKLDVASAIRAADAALYLAKNNGRNNIQLAENVQAATPS
>A0A399FEI0|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MLLGLLKRYGYGSTLVGLVLASVLLSVLITAGINLLIDGQVGRTGVLIAMVVAGSVSLLF
GGIQLRLLQRLEQTREELHRLSITDELTGAYNRRYFLAQATQAFAQARAQGEPFALVLFD
ADDFKRVNDTYGHLAGDRVLQQVVKAARSSLRKGDLLARWGGEEFIALLPGTGREEALRV
AQRLQEGMLQTSLGLEEFRITMSFGVAVCQPSMRDLDDLLSQADDALYRAKAQGKNRIEM
RSTAG
>A0A8F8ARB4|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNSAVADTLATLGRQGQFAAAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSQSIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
HGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFAQDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSVRSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQTFNRPFELH
NGKQVKMTLSIGFALAWEHTSAEKLQELADRNMYQAKHRRTKRLLK
>B5R7E6|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum (strain 287/91 / NCTC 13346)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>B5Y2I5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae (strain 342)|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A1H6FF38|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MAITPTSAHFSKEELAWLKAHPHIHFAPAPNYPPVEFFDKNNIYRGITADFIKYIDEKIG
IHFEIIQLQNWAEVIAQAKLRKVDMWGAAAKTKAREQYMRFTKPYIHLPAVIIVRKEITD
LLNMPDLKGKRVVVIQNYATQAYIQENYPFLKLIPVPDIETGLRMVSFGSADAIVVTNAS
AIYYIEKNGLTNLRVAGESGFEWQLRFAVRSDWPELAAILQKSLDAIPEHKKQEIFRRWI
SLKAPEWKLSKEQIIVLLLVLTTTLIIAILTWNLVLHRKIDTRTKQLHAAMKTQSLILQN
AQIGIAHFVHRKVHWVNPMLAYQCGMPEATLLGKSTRIFFLNNEDYECVGEAYLTLLTKG
ERYETDILLRRGTNGSYWCRMIGQAIDPEHVHEGSIWIIQDISVQKKLEHSLTALATTDP
LTGTYNRRHFSELAKHEIKRSARSNSIFSLLMLDIDHFKHLNDNYGHATGDEALKYFVKT
VRSTLREPDILGRIGGEEFAVLLPDTASISAQHAAERIRQAVASSSFEANGEKIYFTVSI
GLTQAKNNKAGLDALLERADKALYRAKRRGRNRVEMDVN
>A0A6I2HEJ8|diguanylate cyclase|EC 2.7.7.65|Idiomarina loihiensis|TrEMBL
MDSLTNQQLQAGIAELDHAIYLHDQWYKNLLRVLVSRVSPDQSDLMPDAHLKCAFGKWYE
DHSESFFIESQQLKSLFEAHKKVHSGARHLFQRISNGLVIPVDDWDNFESGRERMRREIW
AARHEFAETLKNRDSLTEAQTRTGLLTDLRKQHSLVLRGKQTYALAMLDFDHFKRINDSY
GHAAGDTVLASTVQCVKSHLRPYDRIYRYGGEEFLICMPSTTLEQAGEMMERLRLAISEQ
HFEFGDIQVTASFGVTVLRESQTVEESINGADKAMYKAKNTGRNCVVLDV
>A0A8F9KQU4|diguanylate cyclase|EC 2.7.7.65|Paeniclostridium sordellii|TrEMBL
MNNNLMDLIFDTLPFPMWIKNEDGVFLKINKKFKNTFIDRELTQDDIIGKINKDIFEEDL
AKEYDENHKKVVELKQPMVFEGKTRNKSVMSYLTPILDENENIIVITGVIKDTTETKNYQ
QSLINQNTLLETIINTIPDIIFYKDKQSRYLGGNKAFFKGFFGKKKSEVIGKNDFELHQD
KEVAKAFIERDKEILKNKEDKYTEINILNKDDKILYLESVKTPLINEKGEAWGIVGVARD
MTKRKELEDILTQMSYTDKLTGLYNRAYFEEQINKLDDNEYYPLTLIMGDLNGLKAVNDN
LGHLEGDKLLVEIAKVLKGSCRKEDLVFRWGGDEFIILLPNSDYKLGKEICNRIQLNCKN
TDKTPIPLSISLGVSTKINKQKDIDEILKEAEDMMYIEKLKTKIN
>A0A8G0SPZ7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MIRSARRDRRPTLRAVLGRGHLGVALLAVGLAGLCVTLLGVLALRVYANQNLHLIARSIN
YTVEAAVVFDDSAAANESLALIAANEGVADAKVFNSDGELLARWQRPEDGVLAPLERSLA
SSFLVEPVHMPILHQQQQVGHIEVTGQGRSVLRFLLSGLTGILLCMLLSAWVASHWSRRL
FGDIIRPLRNLASVAHAARRERSFDRRVPETHIAELNELGNDFNALLDELENWQNHLRSE
NATLAHLASHDSLTGLPNRAFFEGRLSRTLRTAERHQEYLALLFIDCDHFKQINDSQGHA
VGDEVLVTVAARVRAQLREHDLVARLGGDEFAVLLTPLQSCEDAQRIAEKIVASMKLPVA
LNDGTSISASLSVGIACYPDDGHDPASLLNAADAAMYQAKRARRGQWHVAHTESSAADFE
KRS
>A0A8B4Z2X2|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. BIGb0149|TrEMBL
MNKPLWGRKLRRLSSPGHVVNFCFVVVLFFSTLLIWREIMVLEEAYVDNQHNNLENVVHE
MDGLLQFNTDRMIFFRNGMQSALETPLDFMILRKAEQEYISRRHEAIWSVALHNRRTLPV
YGVSDTFVDKAPTLSRDNALSGNELMAALELGYLLRLTNNNRGFTERMLYVSRSGFFVST
EALKNTAQALALYSAATRSPWFTRQAQRTNPGRGVVWQTFPEEGALGDAQVVTASIPLDF
RHYWHGVLAMDFSVREMKAFLVNAAKGGQDGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
ETLSYAFLHDNKGGIRLLTRYISWEKLNNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGLFERAIAAAGECERGK
RPFAVIQLDLDYFKRVNDLHGHQSGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVSSSDDCAEVNFENLQSIADRRL
YLAKQNGRNRVCSAG
>A0A8G0SSI7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MTDDAERWKEKYLKSIEQQEKLERRWDARLDLLRRGLVRSTLAAEGSDKAVDQCMKEMRE
VIRSDNMDAGLANLIPRLEKTVLDSEQRRETRMNQVSDALTALVTQLQSLPLPGEVARPL
KKLAKKLDGGVGQSRELPPLLGELSGLQGKALSSLQNQDDEHRPGFLQRLFGKSDSESRA
DTPEPSGPAPNVPVAEAQALPVLASEPQPPVVPAEVQAPAAPEPVIPVRAADVLPTVVEQ
GVQPALTEPVQVQPVAPESSGPALVVPLTSVAESDEQPGEPQQQALAEVEPDELGPSEAP
EVDAEPVDDDGPYALPDAVEPPYSQVALHIEQTLIGLLDDLSLPERHKAQALEMRERVAR
GLNWYELIPVLDDLAVLMLAITDSGQHEFEAYLQQLNERLETFQSHLHEASAGHADNTSA
ARELDSQLREQVDGLQSSVQGAADLNSLKHVLDNRLEGLLVTIDDHQQERDRREQELAGR
LHGLAERVANMEQEALGYREHLEEQRQKALIDPLTGLPNRAAWSEQVEREVLDWQENGGQ
LLMAILDLDHFKRINDGYGHLAGDKVLKIVADQLRKRMRGRDFIARFGGEEFVVLLPQTS
PAAGLQVAETLRAAIEACPFHFKGERVVITTSIGISAFRTGERGDQVLKRADTALYRAKD
LGRNRVEQG
>A0A4V0GM00|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MLERGVLLAFGLPLMIASLLVTADVFVRSVQKISVSRPFKYFIIGILTFTHLYFILSFSM
NSVGFICYQYTTAFIASHFFYGDRGKILILITPCMVVFYLWFVGFSDVGKAFYLPLFGVG
IFVLDFLLSKVKLIRPQQQFYMMYFLTCLLSPRFSMLVHHTTTYDWEAMLAVFVGSFVLL
GSFMWLHRLIEGQEYQVLAELANSKIDALTGCFNYGTYNQDLLQAVSQKKTVTIAMIDLD
HFKKVNDRYGHIAGNELLRTFASRTTTFLEAHFAETYSFYRYGGEEFCLVIEGDVKERTV
AAMTTLCQTISSSMFPVANFEKGTMSLSCGVEASTVCHGDILAAVERADQALYLAKQSGR
NRVCTLPET
>A0A2U3MTX4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter stercoris|TrEMBL
MLTLRSEQISRRLLISMLIIIFSILFIXIPLIVSSYIDYQKSKQTLFEIQSLSAVADLTN
KISRERGPANLAMSSSSEELEENFNGLQQYRAEVDRQIEFTFEILKKSGFNELAIDLKNT
VSKHLNIGRQEVDRYIQTPFEERTSAQFDHAIISMFNVWDYSYSLLKSVMMQSKSKESSI
SSYYTLILILADLRDQAGRVASNVIAYVSMNQPLPSDNIARSLQTQKQVVYLWHLTNAIQ
PEQEKTVEFVDLYLKVKTEFIDRGMPMVMRLIDESQHSQPYFLRGTDLTKEISDKFLTVI
DLQKYILKQSIDFAKTQEREAQLQFIFVSSISILSLFAALFTMIYARKKVFLPLIQARNM
ILDLTNSYEHGNENQQETLTNRYSLYDALQKLRHMMDQRDALEFRLKNIANTDRLTGVLN
RLALDEYLKRLELEPERFYQLSLIMVDIDNFKAVNDHHGHIWGDTVIVRVAECLKSCVNV
SDMIVRFGGDEFLVLIDQMEYEQVLGVAEKIRMEVANLKSMAADSLQDFNVSVSIGVAVG
ASDWNDLFSQADESLFKAKAKGKNIVAG
>A0A517RBR5|diguanylate cyclase|EC 2.7.7.65|Gimesia alba|TrEMBL
MMTILLVSMISLTNDVLILFGAGLLIAVSLGFTAGYFFGKTAPARHLRQAKKHIQGCYQH
VKEALDTAQAACSMLEKFPGMVLTNEQSNELNKKRSNLLELITRLVERKSSDPEQAVAET
KKDKKKKQNFPAMQWALEPEHVHLKLPDTSAFEANLEMMLLGSTSSEQTCGLLLVQMNQY
DQLKERFGIMAPVKFMKTISRLVLHKIRDEDVICLWKSDTLAILFPGYSLEEGQSNAETI
REAIRHHHFRLEATSPEVVVTASLAYINCVPGDSAELVLERGSHALAKSQKKGRNQLIIQ
DSHSYEHKAAV
>A0A1V9DGR0|diguanylate cyclase|EC 2.7.7.65|Pantoea latae|TrEMBL
MAVLPLSVRTLRPVMRVHLLFLAVFLFSLFLTWRELYTLKANDEARQRAALVDLQNGLES
QFQESIDGIIFYRRMFSYALAHPLDADHGRRALARFQHLRAQPAWQLRLDMPRSMPINGV
GDGWLTQDALLQRDPQRLDGELRAALEFSFILQFSDAANDFHSRFWYTSRAGFYISSRPP
QDLAALAASYATMVSRPWFRAGAAQAGLQPRWSGVYQGAEQEGPMLTASMPVIDDGYWYG
TLSMDFTQQRIAGLLNTLRHGALQGSVLLLDKTLQPVASLNVPDGKTLSRAARQQLYAQM
THQPYGALRLERQFISWIKLRNVDGYLVNQQTLTQGLRQDLGRAMLFMLTMWLLFVLLLL
LAHQVIVRLVRRLSQLSARLEWRASYDGLTRLLNRSTFFERFEAEATRCAQLRVPLAVIQ
LDIDHFKSVNDTWGHQAGDRALMRVAATITQALRKNDLAGRVGGEEFCVVLPETSLADAV
KVAERMRQRLAEKTILASASRSFRVTISAGVASSEAQNDYQPQRLQADADRRLYLAKRQG
RNRVVAED
>A0A8F7LV69|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNTESIAKLAKQWKLICDDYSVDILNDAVQFIQRHSEILVVEFYKNMMLEKEASYFLSDD
IVQNRLTKTLNQWLIESFNAPLQHKFEEVAAKQQMVGKVHARIGIPSWLIMRGIREIEKK
IFSLKAESQYAENYTLSMISYIFQILGFSSEIMCRSYEVNIEKNNDIKHSYRLFSAMQDA
SVQKDKQRSSLLDWENELMFKVFSDTQRFTHPALSKSEFGLWFIHKAAYAFSGSEQVDEI
IGRIHEVDLLNNHVLECGRKEQTIALIQQMRSKNREIQHLIDQLFQVAEYIDSGNDALTQ
LLNRRYLETIVSREIHFSRKNHSPLSLLAIDADFFKRINDKHGHAAGDLALQFISEVLFE
SVRGSDYAFRIGGEEFLLLLVDSDLIRAQEIAERIRKRVQDTPIRSSLGSSFNFTVSIGC
ALYDGHPDYQRFLDAADAALYAAKNKGRNNVYLAKSSTA
>A0A1A8T568|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MQTSQIRRTFKWILCIYSVFVSAWLYGASGFNDYFMEVWTSHQGLPHNSVNAITQTDDGY
LWFATWEGVARYNGLSFELFSRDVKTGIADAGIRTLVADQQNRLWIGGARGGLTLHQDFS
WYPQALAKSLINHVLVDHESNLWLAVEGEGVFFRPYLGNNEYGNGRQVLDVGAYRLVQAT
NGVIYAATSAGVYRVSQTNAEQLSIPSVPDKTRIYYVASDHQDELLIASAKGAWRFDGNT
FSPVAEELSGSVVTLIEEDDEGTLWLGTLDKGLARVGYRQVDYIDTQSGLPNNRVISWFQ
DVEGSIWVGTNGGILRLRTAPFQSVDEQAGLLGNFVRTVLQVPGERFLVGSSEGLSLLED
GQAFPASDDLVARQSVLSLAALDSGDALVGTQRSGVYEWRMGKMRQLYSQGNGLPANEVR
ALLEDSKGRRWIGTVNGLVLVESDGSMTQINQHNSDLPDDYIMALMEDHRGRIWIGTAQG
VAFYDRRNQIKQIDISTYEGAQYVFGFYIEPGFIWMATDRGLLRYDAMQNTLSGIGKPAG
LPIDKFFQVIYDHMGSFWLSSNRGIWKVGYVEAHRVASGERHTVNFEHFGEEDGMGSSQA
NGGSNPAAVSSRGGNLVFATANGIALIRPTALKQLYQYRLPVVVEEVDADGVKVNPKIDK
QLGAGVNRVRIKFAGLSYIMPQRLQYQTKLVGFEEEWNYHGNQTVAEYTNLPPGHYEFLV
SARYPYGEWNATKHSLKFEIEPLLWQRKDAQLLASLGLLFSIGSLMYWRVHSLKSRQREL
AQQVRIKTQALREQSEQYERLAKEDPLTGLYNRRAFDERVRRDFMMASQSLRQLNMAIVD
IDHFKQVNDRFSHLVGDEVIKLVAHYLQYTVQPPNIVARWGGEEFTLLIHGDEEEAEKFC
QKLLVGVSQLECEALHMQFNLTVSIGLSNALGCSDYQTLLKRADQALYEAKEAGRNRVVK
YQEFRIY
>A0A447IG35|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MISGPNSRLSRHAWMRIARFTGLILAASVAGSIILTNVFMEMFSEGINLQGLLVAITMPI
VLGGPILLLLFHKQEQLHHANAQLQQMATIDWLTSCLNRGAFTAEVSRRLRFATWQGALF
VIDVDHFKAINDKHGHDRGDDALRLIADAITRAAGERALIGRLGGEEFGVFLPNTTEDKS
RSIAENIRDAVADVAFIVSGARCALSVSIGGASFAGNSDFRALYRLADDQLYLAKNAGRD
RVALWSAA
>A0A2W5RV55|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAGLPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVKRIQEIREVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A554X615|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MTIKARWRRWAREDAQVSEAALRRNLHALAVAAWVVVALNALHVVVFGTLHFDDAVRSTW
AQRVAGAHAAMAVVMLVTGWLARRLQARGALPAAAAWLPLGVSALVLGWAIALTAFDQAI
GGSLSAYVNAAIAVPVVLLLRPRVMVTLMALAWGALAVVLRWVIEDAALLTTHRMNAAST
SVLAALVGVLFWRHFVRTERLQRALADSNQQLQAQHHELQALATRDPLTGLLNRRAFEHE
AQQVLARARRQRHPLALLMLDVDHFKAINDRHGHPAGDAALRQVAACMAEAIRQTDPLAR
LGGEEFVLLLPDTGADQAWHLAEKLRHTLEQTPLPAIGAPLTVSIGLVTVAADATPTLEG
LLQQADQALYAAKRQGRNRTVTWDAEQAARGASTASG
>A0A554X7P6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MRWTIAATTIPQMGDGQSQTAWLRFHFSHVQIRLTAMSHPGATQHVGAPHDRAETPAWPL
PADALLALAADWLWVMDAQFRLVRMARTDGGALPPALSDALGRAPWDHPAFEPGSGHWRR
HRRVLWAHQRFAQLELGWRSPGSRRLRWCAISGQPLFGDNGHFIGYAGVAQDITARKRIE
QTLRATRAQLSELAFYDALTGLPNRRLLLDRIEQALLHQVRAPSWCALLFVDLDDFKAIN
DRYGHAAGDAALVAVGERLRRSVRETDPVGRLGGDEFAALLPDLSLDAPTAQRIAQRVAV
QLLRRLDAALPHLSHVRTPASVGVLLFRGAHALSTLLKQADELMYRAKGGGKGRWSLSGT
PTPG
>A0A0Q0ILJ9|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MPAADFNMNELHWLMDMFNTVDVGLVVLDRDYKVCIWNGFMENHSGLLPSAVKDKDLFDL
FPSIDEKWFRSKSESVFILNNRSFTIWEQQPYIFRFKNYRPITGKADHMYQNATFIPLTT
TTGEVSHICIIIYDVTDEAVNKKELEEANSKLEQMSRTDALTKLTNRGYWEEKLRKEYMR
IVRSGGCSSLLMFDIDHFKKVNDEHGHRGGDEALRHIADLLRKTLRETDLAGRYGGEEFA
VTLLDTDHEGAHIFAERLRTLIENSSIYFDGKQIQLTVSIGFACFDEKFDRYEKWVEAAD
KALYHSKENGRNKVTAYTDL
>A0A8B3JTS1|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MQRDTYVVKRSLQQWLHQRSNPGLIVNLCFIIVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVANGLDRQLQYNVDKLLFFRHSMRDALQTPLAFGVLHNAVTRFNTLRNTTNWQIAVDE
NRTLPINGVSDAFVEKTTLLNRDNDRLANELSAALEVGYLLRLASSHSSNVERVLYVSRA
GFFIATDTPAQPRDISPRYYQLVTQPWFSQQSERENRARAVRWFISPPSPFIGNKRLITA
SVPIYSDHFWYGVVAMDISVDTMKQLLVEAMDNHSEGEYQLYDTRLNMIATSESPESMVN
HFDASELAQIAHAIESDTEGGIRLGSRFISWERLDHFEGVVLRVHTLHEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERANALA
KQCQQQSLPLSVIQIDLDHFKGINDRFGHQAGDKVLSHAGGLIASALRANDVGGRVGGEE
FCVVLPGLTLEEAANVAERIRARIDSKEILVKKSVTLRISASLGVSSAQEKGNYNFEQLQ
SIADARLYEAKQGGRNCVVWRDHNKK
>A0A7U9LP09|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:H28|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A485M7G3|diguanylate cyclase|EC 2.7.7.65|anaerobic digester metagenome|TrEMBL
MISVIPCNDQNQALRVRRFLMALASYVMWMFLTTYCYYKGWFRMSLGDTLTMFAVIIVMH
LCLYLVFMTGLNKRFKDPSLTMLQMILATFWTMVLAYYTDEVRGIALLLYLVVFIFGVFR
LHLRQFFILAVYALTGYGYVIILLLANHPEKINLQAEILYWVVLAAVLSWFSGIGSYINH
IRKKLAKANIELSQANERIRQSAIHDELTGVFNRRQMMKILQREKSLADRGEPSFSLCIF
DLDDFKRVNDTYGHLAGDMVLRTLVQAIKNNVREQDYIARYGGEEFVIILAYPDMGEAVA
CAERIKALASSLNFPGLPDDFRITISMGVTRYLPVESIDAIISRADAALYQAKSSGKNKI
AVEEPPHRKACIRRIS
>A0A6H2GF22|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6H2GD35|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6H2GIG0|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A379YRQ4|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MYTPSVIDTRRSGLSFARRTYLPRVVGLGIGFICVFSVFYTQKTSYWVWGLLIFHGFIWP
HLAYQWARRSAMPFKAEIRNLLIDSFFGGLWVAMMAFNALPSVVILSMMSMNNMASAGKS
LFFKGLAVQVLSALAISALLGFPFQPQSTPLQIYLCLPMIYFYPILLGLVTYRTAKRLAE
KKQELLRISMRDGLTGLYNRRHWEHLLHHQFDSCRRYQHSATLILMDIDRFKTINDTFGH
ALGDEALAVLAEELLIGLRAVDIVGRYGGDEFGAVLPNTSAEQASIALLRIQERLNEIVF
REAPQLRLNISAGIADYHGDMSGYLDWLKAADNALYRAKNNGRNRLELAVPGH
>A0A6L5EHH9|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MSKQFQHVLVTLPHPLLRVVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAAVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWMLSAHETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTLTVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSMMMASDPSLLTTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLDNDL
EQLTMLVCGDINSYSMEKRYYTRAGEVVWALLAVSLVRHPDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYDVPAHVKPTWSVWYNCVL
PEDREHAEKVIRDSLAARLPFKLEFRIAVNDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDMKVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKQLLQTERNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIINAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQELAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEASNFWLISLRLWTSE
GEVMEEQAFRASLVDPALNHALDRRVLHEFFHHAAPAVASKGFSVALPLSAAGLTSATLI
DEILDQLEQSTLPGRLLHLMVPAEALLLHPQESASALQKLRQAGCHIIVSQIGRDLQIFN
LMTKSMADYLLLDSDLSTSIHGNMMDEMLVSIIQGHAQRLGIKTIAGPVQTPIVMDTLSG
IGVDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A174D6B6|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MLLLITAAAYYYFNWQYFSMAGKLRQMQERRVRFVLLSFILNYLFFVACSVLEFPLIVNW
FLFAFLLFFETLIFGKGDGKCALFSTLTGIIYGLSANIFCRSIIAVMLNLPLQRFDNHIT
NADNLKGLPVLLGFLLAGAIMHVFSTVFIERLRLILSHPQHHAFLLEMMAGLFFYLFLNL
LLYSTPLNDLLLKVWSIKSCLFSVIGFYIAVRYTVRICELDDYREKNLHIEQELREQEWE
AQYLRRQAAIDSLTGLYNRQYAEETVNAMLAEGTRFALCFLDLDGLKTVNDRHGHEEGDR
YILTAVREIRSVCRNSDSLFRYGGDELLLLLAGMRAEEAEKKAEAINDRLRNLAEESGFP
YPLSFSYGIVESTEISDCELLIREADQKMYAQKRKKRMARE
>A0A8B5QCV6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls712|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A1X6Y825|diguanylate cyclase|EC 2.7.7.65|Roseivivax jejudonensis|TrEMBL
MLTFPVRLLDRLCPMHVCIDAAGQVTRLGPTIAKVVAAPGAGTGSVFDMFEVTRPSGIDG
IAALVDSTARRLRLRLRHSPHTPLVGHFVADGTGGGVLDLSFGVGVAAALGAHPVSSADF
PPTDLSVEMLFLIESRSAAMSSALRLNRRLHVARLAAEEQAQTDMLTGLCNRRALERELD
RLAGRGAPFAVMLIDLDCFKAVNDGHGHAAGDRMLRMVSDVLRGNIRRGDVAARPGGDEF
VLLLPEPPSQDALRGLAERLIAEIEAPVASDDGPLRISASIGIACHPGGAIEGPERVLDC
ADAALYKAKAAGRGRAIVSAPHRSDRRSG
>A0A174FGG2|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MRMNRQKAQPILKRMLIPMVLLTLIEVMLLSGTFIFGGAIQELDENAKGIVQGKVANRSS
YLQNEMINSWSNVSYTVQLINETAEKLDQDGTIDLDNIGKNSNACLPLVSEISGNLIEML
RSNKVTGAFVVFNNDDPKELREQESFSRPGVYFRDLDPDTSASVRNSDLLIERGSVDLVH
SLDIATDSAWKPQFLFTKEHEEIYNLFLNPQEQGYENPEAASLTELGYWGKPHTLTDDDK
MMISYTVPLITSTGKVYGTLGMEITLDYLATMLPSEELMEDKPASYLLIVQDAETDEYRT
VYSSDSSIAPDMEKLDVSQSSDGNFYFNGADHERYFMDMEYFQLYDSNGPFESDRWGLAG
AVKESDLTEFSNHIMSYIIVAIILTIIMGIAGSVLVSFMISRPIHLVSKHMQQMNTKNKI
GLPRTNIYEFDQLEESIEKLSRDVIDSATKFAQILNKASIRIAGFEIDMDNNTLFLTDGF
FDIFGLKGSIASNMDVQTFIMEMKELEIYKAEEAEDYILYKIPTGEKETFVRLSYSGVED
RRAIGIVEDITKTIQEKQLIEHERDHDLLTGLKNRRAFQRIMQQLFEKGESCLKKAALVM
MDLDNLKQINDKFGHDYGDKYIQAAADSFRKYTPSNTIISRNSGDEFYLFFYGYDTEEDI
TRYENIWPI
>A0A1C3J4S7|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MQANPILLVVTFMLLASLLMLGLSSFIHIDSNYDLFFETNTLVITMYIYYVARHAIRPHK
ALRYGALLLIFNLFYDVSTELKHLDEWADQNELIDTFLEDGLLQIAFLLIAYGITELTGK
IKDQGKRDELTGLYNRKKFDAIKLAEFELIYFDLDGLKETNDLKGHKVGDLMIVRFSQAL
RQTALEDEMVFRVGGDEFVATAQLGRGGEFVSQVNNLLHGENISFSYGIEVTSRDNFKQA
LVESDKAMYEMKKAQRPVQNSWCTSCPNLETNYLNIETTRQTDD
>A0A1H6YN30|diguanylate cyclase|EC 2.7.7.65|Azotobacter beijerinckii|TrEMBL
MPSISPEHQAAEWKRLLEQFPVAVATRVRELATAHQAVLAGYFYAQMLQDEEAMLFLTHE
QVKSRLQGTLQQWIAMLFAARPDEAELLPLIAQQQRIGEIHARINIPIHLVLRGARHLRE
RLFALLCQQPVDAEHKLLGQRLIGETIDLAMEIMSRAFSDAHDRNSRSEEGYRLFSVAQN
IGVEQERQRGALLDWENQLMFDLAVGHSLAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQGMQHIDGVLLPLFEQAAAQMDADRRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQNERTFAVLAIDIDHFKQINDAFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDINANSALGVAEKLRRQAGQERFRLPGEHDLQLT
VSVGVALHDGHPDYQRLLRCADRALYEAKHGGRNRVVLSGGA
>A0A1C3IUC9|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MKRLVGRHLEEMADIRSTRKQKIVHSFSLAAAALFTFYTWAYFQGQHYTLSIFELCFALI
AISNAFYVKKVTAAEYSELILSGVLLVQGVILFLYSHAIPERTLWLYPILAAVIFINDFR
IGIIFSTSFCVFISTLITAMPSSFSLPFSSSHRFILSLFTMSLVCHTSAYYYTKAVSYIQ
RLYKEGIEDLALTGLANRWSFERWATEKLATVDSERSLTALVFLDIDDFKGINDSYGHDV
GDSVLQHFANRLSNNIRTRDRVSHEYDYSIARFAGDEFVLMLYDVPTRKDLDGILDRICG
LFESGCQTNERIKELTLSVGVSLYPQDAQELHELTRCADKAMYVAKHSGKNRYAYYHDNP
VSTLIEELPTNLAFSESESSELEGCLEAKVEGNNVTLLKTRPR
>A0A859T067|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSIAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A381GRR3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRMLKTKADSTPALLSDTICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPYGEMVFLANSDFGMWLSHKGKHILGNSNLL
NEMESLIAEIDNRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMPRYRLLQAN
>A0A1U9K0J8|diguanylate cyclase|EC 2.7.7.65|Paenalcaligenes hominis|TrEMBL
MPNSAIAFLASEWRNSILLFPVEVRALVKHLALTHTQELAAYFYEQMLTDPAAKLFLSHE
AVQTSLMGSMQKWIQQVFSVDETTDFEANVELQHRVGEVHARIDLPVHLVLLGARTLKRK
FALLLEAQPELDSIIAKKAFQFVSDSIDIAMEVMSRAYAKSYDRKSRAEESYRLFSAVHN
AAAEKGRQKSALLDWENQLMFDLTIGTPAENLQSIKQSDFGLWFIHKGAHAFESLPETEI
IFSAMRRIEQILPQFYETDNKIELLKGIRTEARNIQINMNHLFDKYNEVEAGRDELTRLL
SRKYLSVVLSKEVGYSRRRNSSFALIAIDLDYFKRINDNYGHEAGDLVLQQLSELLLSRC
RAGDYVFRLGGEEFLILLVDTNKEGALRTANHIARAIREEKFLTANQKELHLTASIGVTL
FDGHPDYSLSLSRVDKALYQAKNSGRDQVVYLEPNYVR
>A0A4Q3ZPC5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A5I5FDL0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Oslo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A844CRF3|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT693|TrEMBL
MSYIHQPMVKTLRITHVCFLSLFLLITFLFWQQGELFNHGYRTSQLSHLESVTARLESKS
QYQMDNLRYLRRMFIETLHEPQFTPLSQLTSRASNKETLSPLHIQSLPIPDSVLYFKNQS
EDESERLTRREYQALRDIQDLFPLAGGSNRLSSSIYYMSRSGAFIASLSPDVNTLLVQSA
NPLAKQGSFVLGSPLLNPRREPFWTRQNIANTGKTLINGSLPVDFDDRWIGLFGIAVTTQ
TLRLFLSSSLPEDTQSAYLLFDEQMNPLTRPVGSQNGYHLSEKQRLAILEKLTDKSRGTL
RFGHAYVTFGQVRGTGAILVSIQTIGQGLHEDFGRFSILLVVMWLTVILILLGSHRMICR
LIRNMGQLQQEMHRHALHDDLTGVLNRRGFFETTGRISPQYVDYSLIQLDLDHFKKVNDR
FGHQVGDSVLIHATRCIQQAIRSQDIVGRIGGEEFCIYLPNTDLHAAIAVAQRVRKMLVN
TPLKLENDTTLLVTASLGVASHEEAPEGDLEHIQSQADIRLYRAKQQGRNRVCWSGEAES
QA
>A0A514ETJ3|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MNIKNDVSIKYMIVAMLTLFYVSFCVIFFHMQYDNVQEVMKEYLYDARLEILNETYTDDN
LSLALSYLNQQRNPRSAKSDCYFPLEYNSVLNVWGINVDKRQGLANLYGTLQSKNKQISC
ETLNFLHLFDEIYQFRRDERESHNQLVYFIPKDRAYIYFSTPVFNKNYTESNIFKNIDYF
HTKDFLSLMKNKTLSWTYNVRTDIYDDFNTGEKVISVGSIVYNFNDAQGVDIIGYVFKDF
VQDDLKRIIYDRIKPEWRNHVKMIVRDRLKNSEMTYGVSRLFSTNVRLNFSHKYEVSYAY
PVSIILIDNITTFLISFVVYILVLLLMLYIYRMMVVFKGDSYADPLTGCYNRRYLELYTT
NSRLSDKRVGVLVLDCNNFKTINDQLGHDSGDRALVFLAQTLVKVFRKNKDKLIRLGGDE
FCVLILEPDNIEIEKVIARINDKLREFDSDIIFSVSWGYHVSAGANIIEALRSADMKQYE
NKESMKKQA
>A0A518AUE6|diguanylate cyclase|EC 2.7.7.65|Aeoliella mucimassa|TrEMBL
MRAVRAIFESHIKAAIKVCANHPPIAVIVSLLAASVVAVIDFLVGDKVPLVVLYLPSIMM
LCWAVRPMWAYLAAGICSSAWMVDDLLVLERHHVSPHNLWIASVHFVFFTVITGMLVRLR
AAHERERLYARTDALTGLANSKAFHDVADRELARAKRYENQIAVAFIDCDNFKTVNDTLG
HRTGDALLKTIAETMEEGVRKMDTAARMGGDEFAILLPEATMEDAQMVISRLRETLLARM
EKNGWPVTFSIGVAIYRTLPDSIEDIIHSADVLMYEVKQNTKDAVTFQLVA
>A0A5I6CH41|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Oslo|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2T0ANZ7|diguanylate cyclase|EC 2.7.7.65|Clostridium thermopalmarium DSM 5974|TrEMBL
MKEITKYESLRQQVKAYERIFDTVRVVDPVTKKATIYKDDKDISENITCYSRWLDGNECK
DCIIIKALNHKKTFVKIQNNADKMFLIFAVPLELNGDIFALELIKDITDILVFETVYQCE
SHELRNIVQDLNTLIMKDTLTSLYNRRYIDRILPEEIARCDDKNPLSIAMIDVDHFKSIN
DTYGHNAGDIIIKKLGQILSNSIRNDTDWAARYGGDEFLICLPNTDNKKAYKVLERIRKN
VEKINIKIENIKIKVTVSGGLYTLNNNILAPVDLIKYADDKLYNAKEQGRNRIAS
>A0A8B6IMR0|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERAMFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINMLVKQ
LALRADFDFQTRVYSRSGLSEALKRHALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVATVVDSTQQGYLLAEKIRQGVETQPFGLGQNPI
HLTISMGLETREVGHTRITELFNQLLLAADDEMVKAKQTGRNRICMPALTESAP
>A0A2T8QWZ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,12:i:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>W5SV84|diguanylate cyclase|EC 2.7.7.65|Borrelia coriaceae ATCC 43381|TrEMBL
MLGNNIEKVMTKGVILDNVEGISVEPQKLLLVDDTPTNLDVLIDILQDNYEIRVAVNGFD
ALKQVEINNPDLILLDVLLPDVDGYEVCKRLKIDPETRDIPVIFISASDSTDAQLEGFNV
GGVDYILKPFNGKIIDARVKTHLELKRLRDYFKNLSRIDGLTQIPNRRFFTDKFAKSWLQ
ALEHKMNVIVGMLDIDYFKKYNDNYGHINGDECLRLIAKTLNKITIKYKIDIARYGGEEF
ILFSVNKSLDEMIKIVSILIEDIRNLGIVHEYSDISNFVTASIGLAEQIPNDSNFTNIIK
LADDKLYEAKVSGRNQFKY
>A0A1V5F873|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MPLSSLLYRSRATVAALVRSDGIAGRLVVAWLAFTVLLGGYWLQLDHSHTALVSQAESLT
RLRALQTAHALALHTGALFRKLDYLSLHLGEHWLKEGPQGARDALVRAHLALPEDALVGI
DVADAEGRLLYSTVGERLPLELERYGIADFGHFRVHLEGDKGLFIGQPYRGRMTGAWIVP
FSRALVEEGRLRGVIVLSVSVAHLTRALRELYPGTSDVAALVLDDGHFLAHSNRTAGAIG
RSVPSDRPYLLDRVALQGNFDATAPLDGVERYYAWHRVAGFPVVAALGLSKADALAPVRG
TIRDNRLRSGLGSLLLLVAALLISLLWRRHARQGEELGRARRRLEKLVGHFPGMAYQFLL
RADGSTSMPYCSPGVRELYGVGPEGLQDSAMSLFERVHADDLDRLRDSILRSAANLAPWR
CEFRVRGEGDRLRWLLGEANPERTPEGDTLWHGYVHDITERQVAAQQLRESEARLRQAVD
AVRDGLWSWDLARDRIALDERILEMLDRPELGSEMCFDDFCALVHPADRQRQDAMLRAVP
SATPDAPVAGDFRLRAASGRWVWIHARGSVVETNAQGGPRRLVGTFSDITARVAATQLRR
ALLDHSAAAIAMLDADLDILEANSRAHEIFAPPSTPIGGLKLTDLALHEDQAIFIPQHYA
ALRAGGQVNIELPLRDNRGKKRWFDVHGVMLDPEDPDSDTVWTLVDISDKYRTRMALATE
RLRLKTVLERFPGGVLMEDQDGLISSVNRGFCELLGLAAAPDELIGLTHAALCERLGTER
MGWLHRPDADLTAEKRATVEVEGVKGRTLEIDWLPIEHDGRRLGRVWLLRDVTERKERER
RLAELAATDPLTGLPNRRSFLACLDAALDDARREPARGSALLMIDIDHFKHVNDTHGHPV
GDEVLQHAARLIRGGLRQHDRAGRLGGEEFAVLLDDVDADTALTLAERLRRSVEAAPAAT
AAGAVSLTISLGLALVSGGDPARVLGDADAALYRAKRGGRNRVCVAVRTPG
>A0A5C2LZK2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPLDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5V0IQB5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQLINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A5U1Q1W6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLHLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A5U7QGQ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLSGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Y7AHR0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Infantis str. CFSAN000522|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379QAE2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MIGIFVLSVLLLIWHGKYRQKRINLPFISILFGGLWAAHIALKYPALGHYDFSFLLISLL
SVLFIGSIAFAANIVAFTLHSLPSVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKR
YDNFAQQLMFTLLAERETLNGLSMLDPLTGLYNRRGLQNRLDTLQALGSYQHYVLLLDID
HFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDIVCRFGGEEFLVLLTAAEPQQARATAE
RIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHIL
VSDDVRAI
>A0A747SBR5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLVWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A238LE77|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MGSVVRLDSDRVRTVMPNHVWRGMSRPDLRFVAVVVVASVVSSVLTTLLVVGPLVEAIVP
AIVIPAVVSLPASIYMVRQRQKIQMLNMQLEDLLRRDPLTGVLTRRYFLNGVQSAMAGGG
VLLVIDVDAFKSVNDTWGHPAGDRVLTEIAGRIGRAAGPDVRVGRLGGEEFAVFAAGVGL
TDGQRLGEALRSEVAAMPISFDGTAITCTISIGLSMVPSDAEDVDPFMRLADRALYTAKQ
AGRDQVCLAEPLEARA
>A0A1J1JHV1|diguanylate cyclase|EC 2.7.7.65|Planktothrix agardhii|TrEMBL
MKRDRISSENLARQVASIYAFLSSIWIFSSDQILQFLVPNPQSLTLIQSIKGGAFVVITT
TILYFFVRLGTRRLEKSEQRYRTLFFAHPQPMWVYDIKTLKFLAVNEATIEHYGYSEAEF
ILMKITEIILPEEIPRLLESLSKIEMGLNRVGLWQHHKKDGTLISVEVTGHTLEWKGKFA
EVILAQDITKRLQTKAELENYAFSDLLTGLASLSLLLERLQFVINYPSQNSNNFAILSLD
IDRFKPLKYAFGHDLAEQLLIAVAQRLKTLVSPRDIVARVGTDEFAILFTDIGNYNILTE
KIERIHAALDFPFRLDTVTISSATSIGVVLDKLQSQRPEDYLQAADTAMYYAKQKGRGTT
VFYEPSMAKVVAEHLQLEADLQRAIERQQLSLNYQPIVSLETQKVVGFEALVRWYHPDRG
FVSPVQLINLAEKAGLIVSMGQWVLSQACKHLLEWQTRFPDLYVSVNLSEIQLRHPSLIQ
EVKRVLDSLQLPPFSLKLEITESSLMENITWSTGLLEQLKTLKIRLLIDDFGTGYSSLSY
LQKLPVDTLKIDRSFVQNIEVNNKDFEIAKTIINLAHSLGLQVVTEGIETSQQVEIFQQL
RCEFGQGYLFSPPLNPTEVMDFLNQNCSNNRPRCSPENR
>A0A1S8MRE7|diguanylate cyclase|EC 2.7.7.65|Clostridium saccharobutylicum|TrEMBL
MVELRKVIVFIFVSFLFVYMIWINFSVLNKFGHKKLLSALMISGLGLISIGTFFDMISSL
SGMKFRNLIQICFTAGAIIFVTYIILWSNHIAKILANLNQHAHTDAMTGVYNRIGFEREL
RKKSSRKKESFYVMVLDLDKTKEINDNFGHLNGDRYIISAAKIIKDEMDKIGFVGRTGGD
EFVAFLENVNEYDIEKIKHSIKIRVSNIFLKENKNMNISIGYSKYEKDGQDYDELLRIAD
ERMYEDKKKRKNIIRNLQ
>A0A7W8RSV2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. Cpub6|TrEMBL
MDTSKPPQNAATLHPTDDANANAQAQAHALVAEDAPSLACDDALARILADPPAAECPIMV
LLVGDQAVIAEGVREALADEPGIHFRYCASWEDAVRCAEETRATVILQDLVMPGTDGLTL
VRQYRLNPATRDIPIVVLSTNEEPLVKSAAFAAGSSDYLVKLPDRIELIARIRYHSRSYL
HLLQRDEAYRALRQSQRQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWHRGTRDKT
GLGLLMIDVDHFKAYNDTYGYVAGDEVLKSVAHTIEACLGHSLDLAARFGGEEFAVVVPD
TSAGGLRLLAEKIRIAVEDRAITHAGSAEGVVTISIGAAMVVPSAAEPVTTLIEAAGVGL
YRAKHDGKNQVAVSG
>A0A8E0FYR2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 9.0111|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A084XV89|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MIKESIKHIEEWANPRTVIVVTLLLVGALWLALMVSVVSDRHQSIATTGGLLQRMTLAVE
EQTRQKFRVADTFLTSCEHWLQANPDLDPRTDKTFRQLIETFRARTDNSIDIYLLAGDGQ
MFDILDPAQGPLANVADRDYFKGALNSPGLFFGSPTRKPLADHDGLPISLSLRRPTHDIQ
VLLAVIDLPTLTRSYEKQRQPGGAITLLKRDGTVLARAPLDDLLPGHSMAGEVLFSEHLA
QQPQALVLPDASPDTRAREFISYSSMPDFPLVIMVSEDYDEALAAWLRQTAWVILLGLGV
TLPLAVIAYRSLRLLQALASQDAELQRLTTTDLLTGSSSRQHFFETLTEEVARARRRHIP
LTIVLFDIDFFQRINDGYGHAVGDQALILFANTAKEGLRDMDLLGRLGGGEFALLLPNTG
AREAVLVAERIRTAIPGISIPSDNGTVQFTVSVGVSEVQAGDTSIDDLLKRATAALHNAK
AGGYDRVAVV
>L2EBI9|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. HMR-1|TrEMBL
MHSASDTGRLLPSDRFLSRLWLALIKRPRRFILIAFSAAILLILLLILRGMMLSRDTEIE
SVRQMQAVRAVSINALLQLEAERLANIRNYAEHLMQIQDELPALFAHDIQTAFEHRNDDV
WALRTREAAPVYGVSAARLTGLDGFSRDDAKLIPGMAVAIALSHMFSAGHNEPGLRERIA
YVSASGIIVAYPAISEQDVDPTLRTFASAGYFRNSLPLANPTRKQQWSIARSMDDAGESS
LFLSAPVYAGNAFKAVLILEIPRPSLDESLNLAPHHDVNNYLVDHNGILVGAGMRNVHRG
ETLASVLIDKWPADKLAVAFRGDAGILNNEHGSRLIYRKLGNSGLIMVDEVSTRELLQAS
VARLSGTIGAGAVALGLLLCFTLAVVHTLFGHYIDRGEALRTLAETDALTGLANRRVFAS
RFADAYAWCKRDAVPVSLIMLDIDRFKKINDRWGHASGDVVLRTLADALRANVRNVDLPA
RLGGEEFAVLLPRTGIADAANLAEKLRLALQALVCEPVDSADTASIRFTASFGVAQIAPG
EPGNLDSLLMAADQRLYAAKASGRNKVVWDDPQPEEMENEKPVKGA
>A0A377FV59|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MSPMADPREHQDAITARIDPSSWDELPIGLFAFDLGGRIINYNDAFIELLGVSVTTGLAF
ERCTSPQLNLVEASNRVLSGETVRVSGWYHGPERQPRFIRATMSPSVQHDGHITGGVGII
EDATEQRRYEERMEHLSSLDPLTELYNRKKVNDLLAAVAENPSQSSDAAVIMLDIDYFKL
VNDTFGHPTGDLVLRAIAQLLRRNIRKTDAIGRWGGEEFLIVAPHSTLSEGVRLADKLRQ
KVNDEPFGPVPHVTCSFGVSSFEGGKSVEQVLKDADEALYVAKNMGRNQVSSKR
>A0A5M9IPB6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MVHEKPYLSDPPTTEPPRPAAAATLLALMHAQGEVERLSEREQLLSSLLVSVNAVLWAVD
WQTRRVLYVSPAYERIFGRPAGLLLADYREWRNSIHPEDLDYAEYSLARVLDHGAVEDRE
YRIITADGQIRWLSDKCYINQQVGPGEPVIVVGIAEDITEKKQLEMELHRLATTDVLTQS
SNRRHFFECAKQAFDSARAQGAPLAFLLLDIDDFKDVNDTYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCAPEMALQVAERLGKEIQALNFSYEGQAFTVTVSQGLAS
LTDEDSTLDSLFARADAAMYEAKRQGKNRVVAG
>A0A2H6F689|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin06|TrEMBL
MKDKDKTKKQLIEELTEVRQRIAELEKANDNKKRAEGTLQESERQFRKLADNSLVGIYKT
DLEGRILYVNQALCRILGYESPEKMMAGGVPDKYKNRNDRKILIKKLKEKGSVSNFEVEL
INKKGDIVIVLLSAVLDGEIISGMMMDITRRKEIEERLREAAITDDLTGLFNRRGFFTIS
EKQCKLANRTGRGMALLYLDLDGMKTINDELGHKAGDQALVDTANILRESFRESDIIARI
GGDEFAVLLTELSEPDIEYLIADHLQDNLRIRNEQDGLAYELWLSIGIAHYNPEQPSSID
TLISRADALMYKDKKDRKLRRKKRTYLKK
>A0A5P9B8V9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MKFSLKYTMGLVLFCCAILPVYFAGQLILNKQSETLLEQKAIKLNNSTQGITQTVKSELD
LTLRLTEWYAQDRSLLKAGSNVFFSSVVWEKMARFNELADSVSATYILDKDWRPIYDSKG
SLYHFENSQLLSEIKRPKSTYIQGKIFHREFAEPSLANESKSGIAIVAPILPYRLVEGSE
YSPQGYLVVLMGYDRLETKVAPFLFEKESVEFHYSHSVDLNSGSEHEHLVKIANPLFLDP
LSIAVKHNVSDEARQQEMQQAQVVFVRILFATFLLAVVFALVLNHWFSRQLNLLLESVES
YSKEKLPTIKPEQHRFTEFYAFSVLLDKMWRRIGYQLDELTIRNDKLKSAYQQIKVNNAQ
LENFNVQLEQTVEEKTYRLTHSLQREADQKRNIMRIVEFASMRQGVEYRLIPNLVETQLA
ALLSGKSIQFSFTKPTSGVSNTNRVQSLLDSKGQVIGYFNHSSEHLTLNDEDQLIFDLYQ
KQLAAWIELENMTRVDLASGCFNRKAFDDDLSYCERKVIEKGWVLSLLVIDVNGLKQTND
VYGHQAGDRLIKACVDVVQERLQGHSNMYRLGGDEFAVLTLTPSAVPEVETLKEQLYADQ
AQSHILIKGHPIPVLFSIGFSQSDSSALRDMFSNADQDMYTEKRRFYEAQGDS
>A0A1X3L2Z8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H420|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRILPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0V9JSG0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. 50677481|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRKLASEIAIHHAHTLSIEFYRIVLADPHAEEFLSNEQ
VERQLKHALEKWIVDVLSCTSGDVDELIKVQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PIIIDSHHEATEKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQIASLLAWEMDIIYKIMLDADFGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGLFHQTRGTAKALNNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPDGEAIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRHGRNRVELWKPGA
>A0A378TJ34|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MVAEVPIVTSLKRWWRQPDSYNWISSYLRNRGMFTISRALIASITAMVAVVGAVLMASPT
AVQGTGLRALAWTAIVGLLGCTALWIRGWPTKRQSIAFLLVFNLCIAVLIQAQSDPMVGL
VGVVALAIPGGYIACFHSAGFMAYNFAVAVYLCALQVFRHGFGVDAAEVVAALLFVLLMN
TGVPFGVQAVVHVLGIDLLQARHDPLTGLLNRRSFFDRIDEMLYGSRVSPRYLVMIMVDL
DRFKLLNDTRGHAVGDQALIAVGQALTEIARGRVVTGRVGGEEFMIAELTATEERTPLAQ
QVCDAVAALPFPITASVGAVVSRVDHLSDRVRQDVVEDLCTKADAAMYIAKRSGGNQVRH
V
>A0A6V8LVA4|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MPASGFPGAGVLMERLTRLYLRMLAVSLALAPLAAVLYLQWFQDPDLLFDSHAVHELAIA
LAIATSAFVSLVTWLCHRASGEPVLRWLALAFLGFTAVYALHGVYTRASSHHMALFLIYG
PVARLVMAGLLLKGLLVYGEPADPPERRGGLLFWGGWLAGFALLDLLLDALGRSLPGGRL
LLQAVEVCAMACYLSSIVLIVRRGLRSPMMQLYCLSLAFFAQASLGFLLARPWNHQWWMA
HAVFGTGFVVLSHGVARAFLTTRTLSGIYGQEEIMRRLEAANQTALCALERLKTANEQLE
NLAATDPLTGVSNRRDLLARLDVEVSRARRTGAPLSVLSMDLDHFKRINDTFGHQAGDAA
LVAFAGCVHAGLRAHDLFGRLGGEEFLAVLPGAALPEAAHTAERLRLAVERLDVRSGGGS
PRLTVSIGAAQFGPDGQDAEEVCKAADERLYRAKREGRNRVAA
>A0A4P1K5T4|diguanylate cyclase|EC 2.7.7.65|Brevundimonas vancanneytii|TrEMBL
MTTQVETTVRSPEAYALAHRAVDAMQEASVWPTPLNFELWLHYLSAPDSPLSQEMARLLA
SGAPFTDTTAEMLAAEFLPRSRLSEEIRDAGAVLNRELAAVAAAIDKARESQADYGDTLS
QAVDRMASAPDTDSLGVIVSSLSDATRRIRRHTSALERRLESSNREVVKLRDHLEQVRRD
AMTDALTNLANRKAFDEQLQRMCDEAESDGTPIGLALIDIDHFKRFNDTWGHQTGDQVLR
YVASVLARIARTPRIAARYGGEEFAVIFPRETGGAIEAALNAAREEIASRSLRRRSTNDD
LGAVTISIGFALRHSGEAASQFLERADEALYASKRTGRNRVTNAELAASAAA
>A0A518GGD2|diguanylate cyclase|EC 2.7.7.65|Aureliella helgolandensis|TrEMBL
MIEFLCTVAGLFAGVAIHASVMQRQTDRNRFEAAEKDEDADRIHGIAEQLKVISGRVAEN
VNAHSEKVGNISGHISGQLSEQELTSESVVSSINEIIAANEAMQGQLADAQKRIVQQSEM
IEYASKQARTDALTGLANRRALDEFLKGSLASQTDTDNEQVGLLMMDIDHFKNFNDSFGH
TTGDAVLASFARSVVRICGQGCYAARFGGEEFAVILAGQSAEEIVENSAKIRYFVSEQVI
TYEDLQLKITSCAGLTLLRAEDTINSAYERADAGLYQAKKGGRNCGFWLDDEDWVPFPAM
SGEPELLVDVQPLSANVPELEASTPEPDSGDADERLQPVSSSEEDELSGIERDTEAAIES
LTQDMQSVSPVADEVEGIEAAGKTEESELATTSSEILDLASFMSRLDVYFDQLRRADLPA
SAIMIEAMGLEAGSPVDAGNAWETIVGLIQVRQRGIDVICQFRPRTLCIFLPGCAENSAI
DRAAKVLEGFRSALDSWEGDLQPERLAVSLAQFDDVEKPASFLDRLERGLDEAADAPDGE
IVVRSGEESRFQLV
>A0A5C6FNV9|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MSDLNPSCPLESSANPAFAPVVAASPAASDPTNPPVAPPESRVGDLLAGLRENALAPADS
GTASQEAKFENHLAMVRLGMATSLYYALRTKHAPTAAHCLRVALACSAWAQRLGLNDESR
DRIEVAALLHDLGKIGIPDRILRKPGKLSVDEQLAMGTCPQIACEILRGCTADTELLDII
RYADTWYDSRRQDESMRGDALPLGSRMLSIASAFDAMTTDQVYRPALSRERAISELIRGS
GTQFDPELSLDFGVMLEQRPELLQGAVVNRWLQKLGQDVDRPMIGGDAAALQVNTQTTRK
YVKRRDEFFLERLSDHMTEGMVFADGEGTVERWNHAMTRMTGIAADAIIGQRWKDETLRL
RDTDGTRSGCPVTDCLRGGGQVSKKMMIERPGKDPLPVHIQVSPVMGSEPGLQGVVVILH
DLSDKADLEQRLEKLNNKVTRDPLTGVANRAEFDRQLLELTESAKSGEATFSLVICDIDH
FKQVNDVHGHPAGDDALVQFARLLESHSRDDDLVARYGGEEFLLLSANCDNATATRRAEA
VRQALELMPLKSIGNDCITASFGVTEFQSGDTSQTILARADRALLQAKSNGRNRVIQLGS
GRATDASESVGKRSGWLGWLDGNRKAAKEEFVVLTTVPLELAVEKLRGFIADHHAEIIQV
KADQLELRVNALCSSGGRRVADQQITLQVLLTLSDQMSGARVRQTRVHAHIRPVRNRDRR
RRELHACVSQVVSSLNCYLMGQVQSAEEA
>A0A4P7NYY9|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MRNSNKYSIYKAVFYASLFISFIFASQAQAKALNIDWQLFSLNEGQQFKPEPPEAENTLQ
KQDGISLVGGHYLYSGELRIEKEGFYVVDFKNTSTIDQFSFYIYDQNNKLVDRASGGIGS
SEPNPFFLRHGRTFHLKTGQYTLRVEVASPYFIAQPVPYVSTLAHYQQEIKLGNAIVLIG
IGIFLSMGIYYGALSFARSRNTEILYAIFIFSNLLFNAGAHLILSQLFHWHNFYLTSFPI
LISNVIYILFVMKLLEIHPIKNKRLHTMGIISVALLVLFALFAMLFPNWINEMARYGVWV
FLLYGLVAGVTRSLQGSMVARLYLVALMSFIVLASMATLPTQLSSNTIYVEHYGLAAIAM
EVILLALVLTYQVGKLYRERMKMLFSLDQSNKLAHTDAVTQVPNRYALEAELASFEQASS
LTYIDMDNLKLYNDRFGHAKGDELLKMFAALMKKGLGEKGKIYRVGGDEFAVISQDGDTN
RVQTVIESVVEKMQQIGFEHAGVSAGVAFMYEVANTSELKHLADMRMYENKQQRKKQSFQ
QKVSDSSFI
>A0A841A3V4|diguanylate cyclase|EC 2.7.7.65|Methylorubrum rhodesianum|TrEMBL
MSARVLIVDDLYPNVRLLETKLSLEYFDVVVAMNGPDALAICEKGACDVVLLDVMMPGMD
GFEVCRRLKSNPATAHLPVVIVTALDQPADRLRGLDAGADDFLTKPIDDTALMTRVRSLV
RLKAVTDELRSRALATREIGGPDPLVLAAADTGEGARILLVEDRPSAIDRIGTALSQHHQ
VTVESDPHRALVRAPDGGFDLALVSLDLEGFDGLRLCSQLRSLERTRNMALIMIGEMHER
ARITRGLDFGVNDYLLRPVDRNELIARVRTQVRRRRFSETLRGALQASMELAITDDLTGL
HNRRYLDRHLGPVFGEAALQQKGLACLLLDIDRFKSINDTYGHEAGDEVLRAFADRIRQY
VRPIDILARYGGEEIVMVVPGAELPDARAIAERIRERIEATPFAIEGGTRDIGVTVSVGV
SVRRPTDSSPADLLKRADTALYRAKSSGRNRVEAAAA
>A0A8F6P1M1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNLICASDATQEREKK
>A0A822WPU5|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MFSVTNPLYSVRVFSAPLIAIFAISTGLFVWHWKKRARKINIPAVSAIFGILWAWQIDSK
FSLITHDQAMYLIIALLTVLFIGTLAFASNIKAFTLHSLPAFIVCLWLSDQDIWLRMSYS
FALPVVAIAIHNILQRRNDRFAQELLSRLLEERETLTDLSMMDPLTGLYNRRGLQSRLEN
LPAVENGEHFVLLMDIDHFKAYNDHYGHMMGDQALKRVSAAIRDAVRSRDIVARFGGEEF
MVLLTNISLEHARHTAERIRQKVYDLKIPHLFNESVATNVTISIGIAIFENEDVESALER
ADRALYEAKHLGRNNILLSEELQTA
>A0A509E2K3|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MTLQQERQKARLAAVLLLTTIIAILLQAVGLRKTFVLDHQTSYVFNAIDDRANGGETTSS
ISIVEDKFLLECDIVKATYQWPYCEISFNLADEENRGVDFSKYEYIKLWLRYVTPTDTGI
RVQLRNYDDLYSTAGDDTTYKYNLIEFYERNTPYPIIVPLKSMHVPTWWLVSQELPLDKI
GTEFHDVRSLEIATGSAIESGHYKIEIERIEVVGKYMSDRVLYLVLLCIWGLAAFVYLIF
KAGYIKSELKLSERRQKELEALNRLLNVKSRKLEEKLSRDPLTGVLNRDGIAELFNGTDY
SQKVPKLSIMFIDIDHFKKINDNYGHNFGDAVLVKFAQVLSENTRENDILARWGGEEFVL
ACPNTELSFASQLAEKLRKCIENYGWPHALPLTASFGVAQMQKESPTDFIERADKALYTA
KAQGRNRVVVAGWSQL
>A0A377P3Q8|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNPLQSLDVLYINACVTYASLSVSYFVLSKHNALSSHSSLSRRILFGVIAGLISLYLTRS
KMYFTQEVYYSFEIVPMLLVTFFGGGIAGITAWLVNFATTGGFVLDNLLLAVMLVPVLIA
KVWERNTFRTYLKTIIFITLYRVVIVLPFLHTKDHVLDILLYQTVSFICLLVCYQTLSIK
RRSVDAFFKVRAASLLDPMTKVHNRQALEQQMQALSKSRSPCCLVMIDIDNFKSVNDTYG
HLAGDQVLIEVAELIRLITRSSDFVARFGGEEFALIINYDDLNRAYHICERIRLAISNRK
FFLSHGPKIHVTASFGISLFDGKTATLEETLNRADNALYTAKHSGKNRVVIE
>A0A8F6MSA3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MALHSKKLSFTRPIMVSFAGILFSFALIAILVILSQRKDFLEDYHKINGNFTHNLAVNYT
ETILRENDYILGRAAMYFARNDRVNQTINIDPTHGLQMLMHLQNLMPTVSSISLADTEGR
HLRAPEVLPTEKGKSFDARTRPWFIGQAEASNFPHYTRPYLDYFTQHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFIVERDGAVVLHPDTGALFKHYVSEALMD
KMTSGEGHLFDPKSKTWYYYYSFTNPDWFVIYRVSDATLTVITRHETTVVGWGFALAAII
IILFGLYLRHASRSVLMNIINAIKTGDVNQAPRLEAMLSHTIRTNKERELAYVRQATHDA
LTGCKNRRAFDNDVGELLAAHQPFVLALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFGVIFPAELMNSANALLEAWRTTVEKRTWREENLRVTFSAGLGEW
HFEPLEQFIGSVDEALYTAKQQGKNRIVSTASR
>A0A8F8DBT0|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGYALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A0U5DYR0|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MQIPYKPMLRFATPVADASGNRRGILILNYLGKIMLDEFAAASIGLSDDIMLLNAEGYWL
KGKNPDDEWGFMLNRPITFAGRYPDVWLRIRRSEQGQWQAPSGLWTWRSVYPLQSGTVSS
TGTAAAAGPSEARVTSQGYVWKVVSHVSNDQLAALGARTTSRYAWIGATLLALLAVLSWL
LAIALDEQSRARRLLERLATTDGLTGLANRRFFIDQVKQYWGSYQRRPDVPVGVLMMDLD
HFKSVNDTHGHAAGDMVLQQFGRILRKSLRQTDIAGRIGGEEFCVLLRGSEVEGARIYAE
RVRRELEAEQIMIGEARLAVTVSIGASAFMPDDSIPTAAMQRADAALYRAKAAGRNRVEL
AESIPQT
>A0A0U5IGN4|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MRALLARIPIGLRFGLVILLTQAALIAWVVNDNQRLSNAALAQLHETRLTVLAELLSETL
TPLLVQRDIAALQESLDRLGHLPEVHHLEVVDARGRRLAEHAHPHASAHPVAGDGNGDAH
SAPEDAALWVTAIPLRLVGQTYGTLHAGISTGIFAETRQGLIEQSLRNGAIGLGALLLVI
VPLAFWASGRLRRLDAAARAIAAGDLSRRLDDTGNDELGRLAISFNRMADALGQRESALR
AAQEDLERISSSKYRTLFEATTDAVMLFDTQRGLFDCNPAALRLLGCDRDALIGTQPTDL
STTPLPVGSAVPAVDPATDHVWENRDFEWCLQRRDTGDPIEVEVLLTSVPLDGATLLQMV
ARDIGARKGAEAAIKRSEEKYRFLLEYSYDIIYLFATDGSFIFVSPSWSRLMGYSIEETL
ATHFSIYVHPEDLHTCEDAFRAVVETGQMRRDIEYRVRHANGTWRWHGSSAMPFRDETGA
IVGFQGIARDITEQRESQEQLRIAAIAFEAQEGMLVTDAAGIILRVNGTFTRITGYSAAE
AVGQTPRLLKSGRHESEFYTAMWSSIQQSGSWRGEVWNRRKGGEIYPQWLTITAVPGPDG
RITHYVGTLTDITQRKAAEEEIRELAFFDPLTRLPNRRLLLDRLHLALASGRRQGFCGAL
FYIDLDDFKTLNDTLGHDQGDRLPQQVALRLSARIRESDTLARLGGDEFVVMIEHLSPNP
VDAAIQAETLGSGLLGVLRQPYELDGQTHYSAASIGITLFDPQPIRVEELMKQADMAMYR
AKAAGRNTMRFFDPSMQSEISARAALEAQLRLGIQNDRFRLHYQIQVDRDGTVIGAECLL
RWHDPQGRLISPAVFIPLAEQSGLILPIGQWVLHTACIQLSDWATRAPTAHLTLAVNISA
RQFRQTDFVDQVLACIEETGADPSRLKLEITESLLLDDVEGTIGKMIALKSRGVGFALDD
FGTGYSSLSYLKRLPFDQLKIDRTFVLDVLTDTNAAAIARTIIALGRTLELAVIAEGVET
EAQRDWLAAHGCHAYQGYLYGRPEPLERLALDAAKDHP
>A0A731THG8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. VII serovar 40:z4,z24:[z39]|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYAASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVSRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGYFGS
ISIALTLLWGLFTAMLLISWGVIRHMVRNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAQRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVG
GEEFCIVLPDATKAQALQIAERIRQRINDKEMLVMKSTTLRISASMGISSAEEYGDYDFE
QLQLLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6G3F1A6|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESINLTYTAINIIEACVGAVLLRKLLPWYNPLQN
LNDWIRLALGSALVPPLVGGILVHFLVPGAEPLRNFLFWVLSEAIGALALVPLGLLFKPH
YLLRHRNPRLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPPSMTPSNMMVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLINGEINSYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDRRMFELYEIPPHIKPTWQLWHAAMV
PEDRPHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHAIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDANYQTAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSG
IGIDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A6C8RTJ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGALVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISE
SETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKD
LQQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKR
TEQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECV
LPEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMD
MTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVP
LLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNI
GSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFI
DLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARF
IATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGR
VTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPKARNLWLISLKLWSC
EGEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATL
VNDLLEQLENSTLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLK
ANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGV
DLIYGEVIADAQPLDLLVNSSYFAIN
>A0A376NTA6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRT
>A0A2X7G7Y8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQVRGEYHLGDVDLYYPGASLGI
VEVDPETTGADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A377DRB4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVTDMESTYLTKVDVEARLQHIMFARNSQKMYIPENFTVSWDYSLCKRAIDENCFFSDEV
PDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIA
QYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFI
DLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISS
LRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKT
PFVAHPALHS
>A0A8F9BDE8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERVAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLDNSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A828GF13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPILHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHSFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A827BJL9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGILVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWVLKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRELNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANLASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGIASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376Y606|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MCVPTAIFPDEFRKNVSLEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGL
ANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHADGR
>A0A838ARH1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLISLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMAWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVLLLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGRV
TVYEPQQTAKHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPDTRNLWLISLKLWSSE
GEIIDELAFRRSFSDPALNHALDRRILHEFFQQTAKAVASKGLSIALPLSVAGLSSAPLV
DKLLAQLESSPLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSGMGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7H9LZ81|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREAGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHAT
GDQVLIEVAKRLAEFGGLRHQAYRIGGDEFAMVLYGVQSESEVQRICTALSQIFNRPFDL
NNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAKKLVK
>A0A3F3NUI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTREFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B5LPN8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYRGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4U7KBR6|diguanylate cyclase|EC 2.7.7.65|Pectobacterium polonicum|TrEMBL
MNELLNVNEQRDNGESDYNQVVTSEWTQLIATTSQKSFGLLQTLAAQKASEFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILSNTGDHLADLINYQKKIGQIHARIGIPID
LVERGARRLKWQLYDNITQVADDKSLCFDAMRYASISMDIAIEIMNKTYSQSHDLAAKNE
ESYRLFSILENASIERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIAKIITETDDYIRNYSNIALLTQQDYAPLLKTVRSKIYKINMLLSSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKSINDTYGHTA
GDNILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHTIHL
QNGESVTMTISAGIAVYNGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>W7WJI0|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MTLRGPRRGSLLPCRTAPKATAKRGPLCSRALRGVERGGRNWTAARRKDSLQRVLGGSRS
DAKRLQQRLKQLIASWDSDALDEAPSDLAPFDAAAPVGDVAPMVVAEASPAPVSMAWSRV
AAELGATVQAALPSSEARSREVAERLAQLQARIAADGPDGVVEDVAQACTEAQRVLQHRQ
HLTNQLGGLCQELTEGLADLSEDDSWVKGQCEVMRSQLFESDGGLTARGVRSVSQLLLGT
RERQQELRAARKAARDALKDSIHEMLDEIASLGAQTGRFSSQLDGYADEIDRAESLESLA
GTVRQMVAESRAVHEGVSQAQARLALEHSRSAEMQARVVELEDEIRRLSDEVSTDPLTQI
ANRRGLQQAFETEQAKNQRAAQGEGATLAVALIDIDNFKKLNDRLGHASGDAALQFLTHR
VAQALRPGDTLARYGGEEFVVLLPGTPLDEAQRVLTRVQRTLSAELFMSDEQGQVFVTFS
AGVSLYRPGERLEQSLERADEALYEAKHSGKNRTCAA
>A0A8H1S2U9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7D7PAH4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDIESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A6D0KS81|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSALVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8I0CAV9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGPTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8G7Z8Q9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQEHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A789MD71|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSNDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKTANGDDIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8G1CHB2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFVLTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVAGDKRLGKNKY
EPVSALRLFNYCLLAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEVVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2G8YQX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7D7DMF9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTVIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKDPGDTFSNFIS
HWLFPAPIIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLSNRAAFRSGINTLMNSSDARRTSALLFLDGDNFKYINDTWGHAT
GDQVLIEVAKRLAEFGGLRHQAYRIGGDEFAMVLNGVQSESEVQRICTALTQIFNRPFDL
HNGHQTTMTLSIGYAMTIGHASAEKLQELADQNMYQAKHQRAQKLMK
>A0A8G7W033|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYQAKNDGRNRVLAA
>A0A8H2HKJ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEKFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8H1W106|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVTFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKDRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3L9H654|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPFIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVISAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYK
>A0A8G2GQ48|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLFWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A2X1LHF0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYI
QKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLD
NFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRE
RIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAVDIAMYQEKKHKQKTPFV
AHPALHS
>A0A8H9XZ57|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERILLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7T8KVF7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRVRLIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVCASDNA
>A0A378B5C4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A2X1IXV5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKNDFVHKFVFCFWGADSCSHTF
>A0A0L6XW40|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A1C3RGV6|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MDFEALVGRAAQYSSDIILIADKKSEECEALNILYGNPAFWREIGCSAQNVAQCGCHIKL
SQPDFSNHALLSVSDGCQVCTTFRVSLTALPEEETGQTNCYMLVGRPSGASLSEGREQLY
SDIARKFIERPADEAASAAVRAAGLYFDVEAAYAARLDLTSKVMDFRYHWTKMEPASQTQ
QVPQKQTICDWVLKQLQKNEVVQINDLASLPKEDLHLCTTLSESGTKACIMVPVLLSKKT
IWFIGIHCMSTTRHWNKEDVDTFKVVGDLLGNAFTQNEIAWSLKESERRFSDVSANIPGV
VYQMRRNKDGQNYLSYISQGVRELTGWGPASMLSKPELLEEMVLRQDRGRFREAIDKAGL
DFASWSSDVRLQHRDGTTIKWVRSSGRTHRGSNGDTVWNGLLLDISDHHHAEETMRVSEE
RLRRILGTSPISIGISDVKTFKILFANKRLAEMFHLTRNDVIGFDTRKFYSNAKYHRQHW
VETRRGKTLDNVEIECLRSDGTPFWAQITTRQIEYGGREAILWWAFDITDHKKSREALAH
LAHHDSLTGLANRRLFDEHLRNAIALAKRNEAPGVLFYFDLDGFKPVNDQHGHTFGDWVL
HQVGLRLRTVLRDTDIGARLGGDEFGVIAHGMDDIRAIEAVVHKMQEAISQPYVQEDKVA
HIGLSIGVVRFFGTEDDTRKIVMLADSAMYKAKQAGKGSYRLINMPSCDVQKALS
>A0A6D0XRZ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377CJC6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFHSVVARDASKPEITDNHSYGLCQFGRWIDHLGPLDNDELPYVRLMDSAHQHMHNCGRE
LMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFD
HQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGE
EFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGR
ADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A657LJW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEIEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLERRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A385F0I7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii WM99c|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRAIHIYDSEHHLIAQSFKLSSQTSVLEKWFDHWF
LNEPVHLTIYHHQQNVGELTLFGSSEKILQFLKMIMVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQILLDMFEDKDFDNKSALLFIDNNNFKSINDQFGHLAVDE
VLKEMAKRLQTRLRHQDFIARLGGDEFAVILHSITHADHLISIAENLLESCKEPLHLNDQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKTSEQHWFIYKPEN
>A0A1R3TAU3|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MSTTSTPKAPDIAAQILFAMRNMGVVPIPRNYNLFYEAYIGSNPALTRDLAALGTLATQE
ELDELGARYFDHTHSQLLESAREKLHSELNALLVVLQHEQTCLENYNRILDETRAGIADK
NQSSTHLLRTAISMLVDATGNKMTENETTFKNVDRHAAEMQQVRLELDEYKRIANTDSLT
RLSNRRAFDDKLASMYDTSIGLHLSALVLLDVDNFKRINDTFGHPVGDKILASVASIIKA
NVRKDGFIARSGGEEFAIILDGNNQEEIHAVCERIRTSLEKTPFRNSKSGVDYGQVTISI
GYALASQAQNPGELYARADTAMYHAKETGRNRTIFFEDGMQKNYASKSWLIYKQ
>A0A379KFT0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MAKNIHSTLPGNSAPEAAQILLALLHAQGEVARLSEREQLYSSLLDSVNAVLWAFDWETR
QVLYVSPAYERIFGRPTSLVLADFNEWRDSIYPDDLEYAERSLAQVLIKGAVEDREYRIL
NANGQVRWLSDKCYINQQQEGDRVIIVGIAEDITDKKQLEGELHRLATTDVLTQSSNRRH
FFECAGQAFDSARQDGTPLAFLLLDIDDFKQINDSYGHQEGDQVLQRIADSGKAVLRRGD
LFGRIGGEEFAAVFPGCNAQVAEQIAERLQREIQRLSFSHGEQVYGVTVSQGLTGLTDED
DSLDSLFARADAAMYRAKRQGKNQIVRG
>A0A379KP09|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPACPLPTDEAARQRTLDEMHLLDTPAEHYLDTLVRLTQQLAQVDTVLISLIDQERQWFK
ARIGLEASETPRNVSFCGYAILGEGTLLVPDATHDPRFVDNPLVLSAPYIRFYAGHPLRA
GNGKAIGTLCMLDPRPRTLNETQQANFKDLATLAEGYLQLRGLIQSNRDLRLEMDREQRK
AMLDPLTQLWNRNGLTAFQDHERRRAAQSSLRLGAIYADLDHFKSINDRYGHASGDQVLC
ECARRLRAALRPDDLVVRQGGEEFVALVRVNDSEELKGIAERVRQMIGSEPVQLSTGPLR
ASVSIGCTLLNDDEHLDQALERADTGLYSAKQNGRDRVVYVQTVA
>N8WJ09|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri NIPH 900|TrEMBL
MDMLAGQWQHICQNYSLDDLVHTFQFIQDNALILVEEFYKNMLLEKESAEFFSDDLIQQR
LRNTLHQWLLESFSVGINKQYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERKIFELL
EEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAVQKDKQ
RSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIERIHQV
DTLNQIILECQDKTKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLLNRRYL
NTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYSQGSDY
AFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGIQFKFTVSIGCVIYDGHP
DYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A087BP38|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium longum subsp. suis|TrEMBL
MVTIVSENFAPMRTGTYPRKATMARILIVEDEESYREPLVYQLTREGYDVSAAATGEEGL
ELFTKGGIDLVLLDLMLPGIDGTALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDY
VTKPYSFRELLARIRAVMRRNQATAQASGTVDDDIPLVCGDIAMQVGQHQVTVRGETVFF
PLKEFELLEYLMQNKGRVMTRHQLIDRIWGSDYVGDTKTLDVHVKRVRSKIEEDPAHPKY
LTTVRGLGYKIDTPAE
>A0A177SV72|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPSVSPEVQAREWHSMVAQFPDALTHALKGLVETHKVTLAARFYEQMLADPNASLILSHE
DVKSRLGSSMQAWLVKVYSARAGDDFLPLVALQKQVGEVHARIDVPLHLVLGGARYLKKQ
LYQLIAEQGWAAQEHAQILRLASETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNI
TTERERQRGALLDWENSLMFDLAMGASGANLPLLAAADFGLWFRHKGAYAFQNTRESEQI
LAIIRHVDDELLPRFLAAAGDEAARMSLLREIRDRTKSLMFNLDSLFNSANELESGRDVL
TRMLNRKFLPVVIGNEIAIAQKTGQRFSVLSVDIDHFKSINDRFGHDAGDLVLQQAAEIL
SSHSRAGDYVFRMGGEEFLMILVDINNANALKVAEKLRHKIGAETFNLTEGRKHRLTVSI
GVATYSGHPDYQHLLRQADQAMYQAK
>A0A1R3TRS2|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MTIPASNKSRDTSRSSLIVTKITQFITKMNLAPLPRNYELFFEVLSGHNAAMGHDILALG
NAPQQHDIDMIGHKHNLPSFSRMAAAHATSQAATAIEQISARLSAALERSEALLASISNH
PVSDTTPEYLAELLLDIQHEQASLHNFVRQGLEKIREQESNSHKLQAASLKDTLTALPNR
AAFLAKLAEVSQAEGDTSVCLVLVNIDRFREINEKYGTIAGNKALRRLAALFRKSIKKDD
FAARIGGNDFAFLFSGVSQSTAQSIAERLRHTVENLRFATKEGDGEHLTVSMGVAASEGT
ASAAEFYGHAELALLAARSGARNCVIPYSREVAQRSRNSYLMQIGA
>A0A0T9T0B4|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MSSIKKKSASQTQHHHDAARLPTLGRVLGRIHLTVALVSVATAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDSVAANEALSLIAANEEVAEAKILDVNGREMASWTQPDN
GPMHYMEQNVARWALPQPVVLPMVHSGNEIGTIVIVGHGGSLLRFLLQGLAGLLACLVLS
TLVALVLSRRMLYGIIGSLNQITKVAHNVSRNRSFGQRVPSAKIAELNELSNDFNGLLEE
LEVWQKHLTQENDFLAHRAAHDSLTGLANRAFFEGRLSRTLNDCQSDDHAAVLFLDGDRF
KEINDSYGHAAGDVVLTTIADRIRALLRETDLVARLGGDEFAVLLAPIHETDDVLIIANN
IIESMSQPIILADGSEITTSLSIGIAIYPDHAQSPEELLQRADEAMYQAKKNFQSSGGRA
IAQPSDITLTESLG
>A0A485AKR0|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MVFHIMIAVFMVMKYTCDKRRLYLMPIAFAFATSALLMLGTLKSYPNWFLCGGLTNITNY
NDALIFFSFRNILMAILFISSVILYAFKMRDMHSRKIHCIILSIIIVFSTATMWLAWLYS
SNSPTLDVSFIDNNTFKYSTAWNSIISWSLIGIWVVALLIILLVTHLRNIFWYSGAFFCS
CYIFTLFVLMSGQDAASYSWYQARLFETISTLFLIFVLFCDVFTLYRQSNTKYQDSYQNS
IRDPLTRLYNRSYFYDSFTALFPTLAHKQPISVIVSDLDHFKRINDRYGHLQGDKVIQFV
AKVLQDSVRQNDIAARIGGEEFALLLVNTPPDIAQSIAERIRLAISQHDAASSNNQLPES
ITISMGIFTAENLTVPVEECVRRADEAMYRAKAAGRNRVEVWKAL
>A0A485BDK8|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MTVQSWRTLRAQKYQLTFRLYLFLNLVSSALSVFSPIYDVDIFPLPATLIAVGSGILLLW
NWRYARIRLNVPIISAVFGCLWAWHILSKTQILYSANDNFQLVALFSVLFVGTIAFSNNI
IAFALHSLPTFIVCLITSGTEQWWRMAYCFALPLIGIAIQYVIQRRNDTFAQGLMYKLLE
ERETLNGLSMLDPLTGLYNRRGFQFRLESLLAVGAGQHSVLLLDIDHFKAYNDHYGHMMG
DQALMRVSAAVRNSVRSRDIVTRFGGEEFMILLPNCDIPTAMQAAERIRQHVYDLKIPHM
FNASVATHVTVSIGVAPLVDKDINGAIAMADKALYEAKNMGRNNILTSDQVPAV
>A0A485CC56|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MLSENKIEILRKKIPQAWIEQASNVEGDFYDDKEKVYVFYRTYMNPDWFAFTIVHECDYQ
DITSIARKTFWIVTLSCLVLYMIMVVLAKLYMEKIISKLYMGINGIDPNKDKVSITSIYE
NVKENQQNLERAVYESTTDGLTHIFNRRKFDNDMRNLIEKNQSFYLAIIDIDDFKKINDT
YGHDAGDNVLRTVEQNRQSGLWVMNIIFIDLAVKNYV
>A0A729IY18|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:z4,z32:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHWRTERSLN
>A0A485A512|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MDLDRFKLINDAWGHHVGDNLLVSVANRMSACLSPKMTLARIGGDEFILLAPQLQ
>A0A0T9U3N1|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MSELESLSTLYRDACVTYATLSISYFALSKSSAFSYHGEVWKRVVFGLVAGMVSLYLNQD
QWIISGSFFYSFELIPIVLVTFYGGWLSGLTALIINFVFTGWVTLDNILITIIFIPLLFS
RVWEKKNSRIFYTTIILIAIYRMVAAVLFVPEQLVWTQMVIYQLISALCLAICYHALNFK
ERHIYAYFTMKSRANIDKLTQLNNRASVDYRLSTIHSSRQACGLMILDLDHFKSVNDTYG
HDGGDLLLTEVGKLLTSTIRDEDFVGRFGGEEFIVITHSHDPQTIKTVAERIRQQVENLD
VELPDGQKMKATMSIGASLYLPGMSMLKAIKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRVEGERRRRRS
>A0A2N7QUS6|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MEWIARLAHAGTLLIVNALLAGLSSAIFLTLYATGQKGRRLHGVLLWGLSYAAFAVGFAV
LILPGFQIDFAYLQLTGNLIIDVGAVLTLLGVTAYLELPRRRLWVLVPVALLAIVEIGSV
IAGGENLRLMVILGNALTALLTIATGDALWHCVDKPRRAVARVAAAFHFLWAIMLLLRGA
WWWFHPFADVTEDPTSTFGLLSRLILTWVITPSFLWMLTRELDAELIRQAHQDPLTGVPN
RRVIWEQGERMAAQVDRQETSMAVLMIDVDHFKAINDRWGHDGGDQVLVAIAQTLQRYVR
DEDLLARVGGEEFMVLIRHGDEATVGEIAERLRRAIESHPIALPSGEALNCTASIGYCLS
PRGQGHWRDIVISADQALYAAKRQGRNRVVGSPRQPT
>A0A729FTU2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:z4,z32:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTL
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7V8Q037|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MSASPPMFLTVDVRRSGLRFSQRVYIPRIVGTILCALFISSVLITRPIPTLLWVMLFLNT
FIWPHIAYLLSLRSRDPMRCEKRNLLLDVAFGGIWIGFMGVNLLPSALIVAMVGMNCTAG
GGIKLFVQGIVLLCVSCALTLVLFAVPVSLDTTPIQIYACLPMLLIYPISLGYVTYATAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDICQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNCIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMSQYVGWLKAADMALYRAKNKGRRRTEVA
>A0A8B4N9J3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter nosocomialis|TrEMBL
MSGLRSEHISNRLFFFMLVIILSLLFMAVPLIVSSYQEYLKTKQALVEIKSLKSIAEVAN
KVSKERAPANKLMSSNAADFLKNQKKLLDYRLTVDQQINETIRILEEEGYSDLARILDTK
FKDDLKQARAVVDYYAATPEQARTSLQFDNAILGMFGAWDSCREILQKLMLQLKSKDSQI
NNYFTLIVVLTDMRDQAGRTASNVIAPVTFKETIPNDNRARSLQTQQQARYLWALVDTLQ
SEQAKTPEYHRLYARVKTEFLDKGVPIVGQLLEESQKHEAYHLNGTELTDQIVDKFTTVI
DLQNFLLNKSVLIASQENYLAKKKFFLTLLISSISLAAALLTLIYAKRRVFEPLIQARTL
ILDLSHSKDYPVDELNPKKGEFISLFEAIDRLQRMLKQRDAFEFQLKNIANTDPLTGVSN
RLALSEYLKIVESYPQKFSQTCLMIIDIDRFKDVNDQYGHIVGDQVIKRITDQLKANVRA
SDLIVRYGGDEFLILLEQVPFLDARLLAEKIRIAIALEEINLSGSNEKLHVSVSIGFAIG
ATSWMELLEKADRSLLRAKARGRNVVEG
>A0A177H7P0|diguanylate cyclase|EC 2.7.7.65|Rhodobacteraceae bacterium SB2|TrEMBL
MDNILNILCPCHLIINRAGVIEHVAPTMQKILQGETARLQHVLDLFSIKPRSGHLRGCSM
FELDGQKFHLSLRRFLDLRWNGVVLRLQDRDKAIIPISFGMALKETAECFELTHADFGPS
ELAVDMLCLLEAQSAVRAASRAVTQRIEGAKKNAEIAALTDPLTGLGNRRSLIESLASFA
RQNISFGIIQLDLDHFKTVNDQLGHPVGDRVLVELSNILRQEIRAHDVAVRLGGDEFILL
ITGTNDPTELLGLAERLLARLKPPLTIQTHKVQLGLSMGGRIVEAAERWSMIDILQAVDQ
ALYHSKRRGKGRFTFCS
>G3ACJ1|diguanylate cyclase|EC 2.7.7.65|Ralstonia syzygii R24|TrEMBL
MPSPAIVADGAEAALEAARAALRSPAAADVPAMVLLVDDQAIVAEAVRQALAAEDGVDFH
YCARSEEAVATAVQTRPTVILQDLVMPGTDGLTLVREYRANPALRDVPIIVLSTKEEPVI
KSAAFAAGANDYLVKLPDRIELLARIRYHSRSYVSLLQRDEAYRALRQSQQQLLEANLEL
RRLTNSDGLTGLSNRRYLDEYLSAEWRRSEREQMPLSFLMIDVDNFKLYNDTYGHVAGDE
VLKRIAVTVDGCLGRPGGLAARFGGEEFAVVLPGIGLDVLAQLAETIRLAIEALRVPHAQ
SSTGAHLTVSVGGAVMVPAAGAAMTGLVEAADLALYRAKHAGKNRAVVGAGAGAGAGRGG
>A0A1R3U324|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MPDFFTLYLVVLLLNLSHCLIWGLIAYRYRDMRAARYWLAGSGASAVGGIALSLQGENGL
LLNTVAGNGFIILGFYLNWFGARRLHGEKVEWIHFSYLLGGSVLVMLATFHLWYGRNPVY
TLAQSLPLTLTALYLMRPSRRDLGAVIASTAMVMGGLSHCIIAGGNMLIVTGLRPDLQIY
QSASIDLLVFLFAAVVWNFGFLICTVDRLQTEIERLANEDELTGVGNRRMFMNRLNEICR
KREGVNFSLLLFDLDRFKVINDKYGHAAGDAALKHATAVITKQLRPGDAFARLGGDEFSL
LLSATTAAEATAIAERILSAVKGTTFSWGTLQLGLAVSIGIASSKGSLVTPETLLENADR
ALYEAKRRGRDGYSLFGSHLKPASNIVRLGDFVPSGSAART
>A0A0M9EHP4|diguanylate cyclase|EC 2.7.7.65|Shimia sp. SK013|TrEMBL
MTDTQDMLRMLDVLCPMHVQLDANGLISHAGPTLQKLYPDLALPGQGFLDVFELSRPKRI
TNMEGLLATAGQKLHLRKRLKPLTGLKGVLVPMPMTGGAMVNLGFGISILDAVSDYDLNA
ADFAATDLTIEMLYLVEAKSAAMEASRKLNLRLQGAMIAAEEQAFTDTLTGLKNRRALEH
ILPRLVKDCTPFGLMQVDLDFFKQVNDALGHAAGDAVLQHVARVLVESSRDEDCVARVGG
DEFVLVFRGATDLEIMGRIADRIISEVENPVPFRDTICKVSASVGIAMYSGCGETDMDQL
LSDADTALYASKHAGRSTYRVFEPQMRDSGPLAG
>A0A1R3U2S4|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MAEISRADIRSRIGVVLWLLDPVIDAPKEARTLLLGQLLSSPLAIIMGSVNSSLVTAIGF
FRHDGNIFAVFVTLELLMLTLRLMVMRYISHVKAAGKLPFVDLSILFSVLWCALQGSFAF
FIMQTGDTVLMVLSATLIMGIIGPICARNFSAPRLALLLVCLCDLPFKTGAVLSGDPWLF
ALVIMTPPFFLGAMQVILTFQKSLISTLQAEIRNNFLANHDALTGLLNRQGLDAALAGLL
ENNSRVAILGADLDGFKQANDEFGHLVGDKLLREVGVRLANSVRAGDLVARIGGDEFLIV
IKGLPPEDVMHITERLIASVAEEPIEIDGIVVKVGVSIGYSCYPEDAKEIEQLRLFADSA
LYSVKRAVKGIAHRFIAFGETTGRPRIAETTDLVIEPTL
>A0A1F2PER6|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MGGFLKLEGKARDDFYQAKYDYYKRFNLGVLFASAFMFLILFVADWQVDGAALGRSFLIR
SSVVVPMLVVFWAYQKINNYKIMGILTYLMVHAMIWGNIWAGSYLADQSYVNEGFLIMSL
VLLLVSFAAPPFVAIIGQLGLIGDILLADHLYHFENINAILTFNIQVIVLLCLVDFIIAG
FYYDHYITQRKLEFALFHDPLTQVFNRRQLHKIMGEGHDLTFLSDAIAILIMDIDHFKLV
NDRYGHDEGDRILQFVADCIRNSLRGPDMVMRWGGEEFVVILFDCPADQAMAVAERIRKS
VEKSVNGVCAITISLGVAIYAGGDCFETINQADSALYVAKRQGRNQVVSYEALDEKLRQE
VARARQNEV
>A0A1F2PLS6|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MIIKFVSIYLYIGVLLLSFMFINSFVRGKSSYAKAFGALSLTLQIYLLGYLVEINASSLQ
DMYFWNQVQYFGIPFFPALWLMVSMLYTGKGKFLQGFGGLVVFAIPIFTFLLRLSNDWHH
LYYSQIGIHQFMGVNYMLLIKGPWYYIQTAYVLITLVLCTWFYVQRFRNSTGDERIQFRL
LLLASVLPYLALLLVTVNLFGIGIDYTALILPPCVLLINLSLTRYNFLEIKDLARERVFE
DSSAGLILMNRFYRVVDFNEASITFFSWFNASLKEDQLEILLAKHPDLWERIKNSEDQVC
HFSVAKEDRYVNINTRSIQNKKETVGHLITFEDVTERESLKQRLTEIANTDELTGLNNRR
RFRECAEKADQQARSVQETLSVLMMDIDFFKKINDSYGHHGGDAVLRNFSAMLKEAFRGT
DIVGRIGGEEFAVVLLNTDAEKAYAKAEDFRKAVAQKTTIFGEKCITVTVSIGVAERDQT
TTDFDALINHADHALYQAKHSGRNRTVIAH
>A0A174JYP0|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MKKKKIIILSIMIIVVALLLEASILKYVNDRNAHRTSKVLLDRVITVLDKNDESRNELIE
SLKDDYIVRAKAVSYMIDADPAVEYDVNELQKIAKLMAVDEIHLFDDQGTIYSGSAPNYF
GYNFDSGAQMEYFKPMLKDKSLTMCQDVTPNTAEGKKMMYAITWNEDGTKMLQVGIEPKR
LLNEIKQNNISNVVAGMPVYKAMEIMVADGDTQVIEGATDSSKLGEKLEDVGISVDHVSA
DGATVTRIRMDGKHCRCMMHQNDNYIVIVTVEDSFYQQGGMIAIFIVGAYLVLASCCITY
MFSKVMKERLEKEKLIYTSNTDELTRCLNRHAYENDMKKLNLSEEWVYISVDLNGLKRAN
DSYGHMAGDELICAAADCMIDSFHEYGKVYRIGGDEFAVIITENTSQVEELIHGFDSNVA
NWHGKFVDSMTVSYGWVFSTERNWGSAYEISKAADARMYQSKERYYKESGADRR
>A0A1C5QL57|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKQNIKRLLPVSIVIGITIIVSIFLYHKVMDREEERCWQILSDSAKTISAEIQMKFQDNI
TTLGLAANAMVQENKLEPKQIASVHLDAFAKNTIFSRIDVLYPDNTILYEDGHLKHLRQD
LDFNAIAALGEHISHRLTDSETGNESFYYYMPVIKSGEIKAILTGVIDTTVLADVFQISF
YDGHAAICLVDSADGNYALDTRYSTLGNAYDMPGPALLKGYENIDLKSEVKSLKTGVIAF
ESSINGKDNYMHYSPVGMFDWELLVIAQEDVVFSSLLYLKKLMILAGIIEFLLLGLYIAW
NFYTVEQLAKSEKRTQEQLKNSNTLIQCVTELSSDKDINISIQNLLGIITQYFDSDRTYI
FELNPEKTMLRNTYEYVKGGVSVQIDNLQEVPITVLPKWMESFLKFKPYYISNLEQERGF
ESYNMLKEQDVNRLIAVPLGKRGDVIGFVGVDNPRQFYNDATLLSSIQFFLTNSLATKKQ
QEQLQYMSYRDMLTFLFNRNKYIEVLDSHQGKVLENVGAAYIDLNGLKQINDSQGHEAGD
AFIQNAARVLSRVFPDKVYRIGGDEFVIIQSSIEEREFHNRINRLQEYMKQDQISISIGF
LWKASCENLEDMLKEADHRMYEAKKTYYQTADRRTHNH
>A0A0E4A2D0|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MTSQMKSMRTLTREWLALPDQYDRFTRYLRDNGLTTATRLLLGIIVIGLGVCALLNRFSP
AGPTSTIALFFNTVVVISCFMVGVSWWVFGPTKRRSFGFVVFCDIAVTISVLGDSSQLAR
LLTCVIYALIGIYIAYFHNPKLQIAHLTFSVVMIVVAAQPILFGPERDPALGVSKVLVVV
TALVVCAFISQIVLTMLSMDASSSDLDPLTGLLNRRGLDRHVEKVLAEFQRQESAALLVI
AIDIDRFKTINDVHGHDVGDRIILRVSQRLSAWAHADAVVARVGGDEFILAQRLSVPAIG
PMLDSIGPAMHSNTDEIPSTSSIGIAVRTHKFVAGEERATAFTDMQKVADSAMYESKRLG
GGRVHTIVTTASR
>A0A1C5QSH2|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MEEKKRYNLGVLIGGVHTYFPKEHIKGISEAASELDVNVCFFLGTRTKDFFEDVLGSKQK
NSYDYQFNTIHDYSLIGGLDGLIINYGTLGIQLREVDPNEFARKYNGITTVFLTEVVDVP
NCHSLICDNKGGIAMVISHLVEEHHLSRILFMAGPEHNTDAIERKEAYLETMKKYGLPVT
HGMIAQGDYSEFVDKQVERLLDSNPDAQAIVFANDEMAFAGYRVCEKRGLVVGKDIMITG
FDDCERASGMEPPLTTIQQDGELMGKMAVYDLVNRLDGKDPGKEAVSRRVPVSFVKRESC
GCVSEDVSKKETPMGLGAQVHRLNKTIAGMKLELISFQRKSWFIPVLARDLNDCMDDEQA
FLKEIMEKMRELHTRCTHLFLLDEPIVYDGKRKWTCPYNLHLAASYENGRIITKAAYERP
LVMKENGICDLMEDEERHQFMVFLLFSGEKQYGLLACDIDQEDFPFFYVISLQIGLSLHY
LEISKAEAARRLEMSRDIEEIKEKNRVLGIISEYDELTGLLNLRGFMEHTKRVCQAGNGQ
RAYMIYGDLDHLKEINDTWGHPAGNFALRSVAEILKGCLRSNDILGRVGGDEYIIMLECE
EADFGEKFRERVKMACKLFNEKSGKPFLVEISLGIAEFRPNISTDIQQVISLADQQLYEA
KKHRKKSVSRANDEGA
>A0A1C6KAM7|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKKKLVFLAFATIAIALLLEAGILKYVNDSNTYRMSKVLLDRVITVLNKNDDSENGLIE
SLKDDYIVRAKAVSYIIDAKPQVEYDVEELQKIADLILVDEIHLFDKNGYIYSGTLPKYY
GFSFDSGEQMEYFKPMLKNKNLTMCQDVTPNTAEGKELMYAITWNEAGTRMIQIGIEPKR
LLKELKQNEISAVVSDMPVYKGIEIFVADSQTKIVKGATDSRQIGVKLEGLVVSSDKKSG
ETDVRLIRIGGKRCKCLLSQYDDYIVAVTIDSSFYRQGNIFAVLIVGVYLVLASCCMFYL
LSRVMKEKYEKEKLLYISNTDELTRCFNRHAYEERINNLDLREEWIYISLDLNNLKHTND
SLGHAAGDELICAAANCMRESFGKYGNVYRIGGDEFVVIITGNTKEFQSIIESFDRRVAQ
WHGKLVDSMTISWGYVFSSEKEWDNIYDIAKEADERMYKNKERYYQESKIVRRR
>A0A1F2PZI5|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MDPLLHTWPVSSTVMLWGSKSGRGSVLRLVRLTIGFCSLNFSIVAFLFLLSGEGPDGPFA
RSWLVGIATVNLIPTILWFVGRIRGSRMLKLYGLWADLGTASILITFTSHNAALFGAALF
VATGAYFTYFLDYRWLAFHLAFATTFVIALTVLGLTNGDYSTTSVIARTDVVLCAVIFIP
ATIQFTWRQLLARATGSKVDALTGLLNRRGLWDMSERIWSVASANRADIAVAVVDIDKFK
AVNDTFGHEVGDAVIIRTGTRLQAHVNGFGYAARTGGEEFTVVMIGTPYGLRKRIATLPK
AVVNASDDPLATVSVGAATLPFIPHQEEFDYNEFSRAIVAADHLMYDAKSAGGNTANTAP
MAVPRRRAH
>H5V0W0|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii NBRC 105704|TrEMBL
MSAETKQHPWRLKHPIKIVNICFLVVFLCSTLLTWREMVVLENGWTASQKNRIQNIAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAEFSRQRHSDAWQIRLDATRGLPIN
GVSDEHVRKNPLLNRDEQRLERELIAALEFGAILQLANPQQESQHRTFYTSRAGFFLSNA
QHPAADAIASRYHRLITRPYFHSHTQQNNPQRGVRWTRNKEVNREGDHVITASLPLDYQN
QWYGVLAMDFPQGTMNTFLNEAMFRRENGEILLLDNDFQVIASSAATSPAASGFTQRDRE
ILSGEMKQHSQGGMRIGSRYVSWAKLNFFDGMLVRSYSLKQSLSGEFGSILLVLGILWLL
FSLMLLGSWYVLRRMVRNMYRLQETLRWRVSYDSHTHLYSRGAFIERAKRIAARCQHQGL
PFSLIQIDLDYFKRINDTWGHQAGDQALIHAAGILRKALRGDDIAGRVGGEEFCVVLPNT
LLPEAAAIAERIRERLNSKEILARPNTTIRITASFGVSCAIPGGDYDFEHLQSIADRRLY
QAKQAGRNRVCSTG
>A0A174FBK1|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MGRKIRSRNIAFRLTVVFVCFAAFQSSLLAGIMVGSGVLKRAEQNEYRIFSEKVNGRKNN
LENEMNNIWTNFDYDEERISRYFEETDTGNLPGKEDEVLEELAPIILDSLYHTKTTGAFL
ILPGQDGTENSLASLYFRNNNPDKAGQNNENLYMLAGPWNVADKLKIATTANWSYRLELS
SSNRDFYTKPYEAANEYGRSAWLGYWSTPFKVNPQDEDVITYSVPVFDGKGNVAAIFGVE
ISVNYLYRFLPARDLQNTDSYGYVIATGSMEKGLKLSITYGAVQRRMLEAGEMMELESVD
EEDGIYRLLNHNSSHDIYVSASRMGMYYHNTPFEGEEWYLMGLMEKPVLLHFPQKIERLL
FFALLATTGIGLIIALFVSVWFTRHAKLMELSGLPLGVFELRPHSGKVFMTSRIPSLLNL
TWEQERIFTRDKMKFTEFLKEFENLRDGGDDTFRLESEDGSKWIKITKKIMDGTVRCVVE
DVTDEVLQTKALQVERDRDGLTGVGNRLAFEKKMECLRDNFGSGNRPGFVMCDLNNLKCV
NDEFGHDKGDEYIQAAADAIRTAFPGEAVYRIGGDEFAVYLENKDAETAVEGIARIKTAM
EEYSRTQEFHAAIASGYAFYTPGRDLEVKDIMTRADAYMYRHKRRMKR
>A0A378J274|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MSDKIDEKELPFKSVLDQTDDVVIITAVEPLNEPFGPKILYVNKAFTTLTGYTQEEVLGK
TPRILQGDKTDKNTLKRIRIALEKKEAIHVELLNYAKDQTEYWLDFTIIPIKDSKKRIQY
FAAIEHDITERKKLEDAKAMLSALVEFSGEAIIGKNLEGIIQSWNEAARNLYGYTEKEAI
GANIKMLFPKERKREFQYIMDKMVKDQPIKGFETVRMHKEGHIIPVSLTIAPIKNARGKI
IGASTTARDITQQKINEEKLKHLAEHDVLTGLINRPLFEDRLVQALAIAKRTNCNMAVCF
LDIDGFKNINDTYGHDIGDLVLCTAAQCMQKCIRDIDTLARFGGDEFALILSYLNEEKDV
IKIVKKLIRLFSKGFLIENYNLKVTLSIGISLYPRDGMNDLLKKADAAMYYVKKHGKNNF
IFFNAIDKN
>A0A1V5W8L6|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MGIKSERAATFLISMASVVTLMISIIWLVYIFSIKGYIVKDAKENMRGIASLVQYSALNG
SGKFEQLHTFCRDENFTVRLISLEPLNIANLAEEEDAVALSLFSKGLGEYFTIYKERNKT
FIKLLSPIFYNDSCLKCHRQSESLFPGAVSVIFDMTYTESRSETLGTVALIAFIITLVMA
LMISFVYGRKKIRDLRMLSSDIEKFRYIDDVTLFYNRTFFLKRLGEEFERSRRYRSNLSL
MIISLDLLSDGTTLSQNKKTEILKSSAEIIKSHCRDSDIYGRYSDNAFAIIIPEATREGV
SIMADKVMKKILAKEGSREVMVSIGIAFMNFEEAYSPEILLYDAEAALSRAIEHRENRIE
FS
>A0A6N3HJ34|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MKNNRLFKTNAVISLILLIGFALTAALSYHANYRTSLDSIEQISTLTADGICYQLTAMFT
KPVNVSLTMSHDSLLREHLSKETEYLEDEKYVDTTRNYLDTYREKYGFDSVFLVSAATSR
YYNFNGIDRVLTEDSPENAWYYDLLKSDAEYSMNVDNDEVEGADNVLTVFVNCKVKAGDG
SILGIVGVGIRIDYLEELLRTYEDKFNVTAGLLGEDGTIEISTAHNGHVKTDWFELNGRH
NIRGQILDWREKNTNLEIWADKEESGKERSYIVARYIPELNWHLVVEQNTGQLLHGIRIQ
IILTGILLIIIVVSVLLIITAVIRNFNKQITELMEERQESFVRATEQLYDNIYELNITKN
CSVGKRTREYFKSLGANDLPYSEGLRVIADKQIKEEFREGYVSTFDPPNVIREYERGNHH
LRYDFQMSEDADKYFWMRIDAYVFYSAEDDSIHMFTYRKNIEEEKKIQIQAVLDEMTRFY
SKRETERLIETVLSGTPGGRYAFFIFDIDNFKQANDCYGHRFGDFCIKEFSSIIRKHFRE
KDILGRIGGDEFAAFIPVPDIGWARKKAGELAEALNTVIENQDRSWQMSVSIGVAVYPEA
GTLFEELYGNADKALYETKIRGRNGFTIFQPYDEKGQETELENE
>A0A5S9R2B1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MGAIRSWWRHPDQYDWLSSYMHARGFTRSAQILMAVVAASGALVPANAFWSPVPANLALL
IPVAVIAGVAGLSYCVLWLTRWPTRIQSIGFASFICLSIGLGSWAAADPQIGLMACAALA
VSGGYFAFFHSAPLVAANLAVALVVAAVHVAELATQGELVLALTMFFLVIELNAGVPLAI
QVMVHALGIDLIKSDRDPLTGLFNRRSFQRAVVATVLDGQPAGSYLAFAMIDLDRFKALN
DAYGHSTGDDALVAVGRALCTTLPESAIVGRVGGEEFLAADIIATPVAESLGEQAREAIT
TTGYGLTGSVGTAAVEAAALNSGTIVDSLHWLTVEADVAMYTAKRAGGNQVHHHGPLEAP
RRAPDVERMHGETPQ
>A0A7L6PQR7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00127|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHREFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>Q323V8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGSYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>Q8EC11|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MNSKRLTSLKYKITLAFYIILGMAIVNGIIAILLSQKLKTEIEQLVNSEAVKVTTALQLA
KNSERLQIITTELNHYDTEEQRLTLLKELTTQWEYLLKDTKVLFSLETTPNTHQALNRTI
DTQLYFQQQLPLLDTLTDSALQAKLQAQNIQANLAGMSSAFSDEIQAQLNLTHEHFHLLL
EQKNLDGISDNLNQHQALSAYFHQGEHLFALLEEVKNSQNIVEINRLQREAMRLLIQMEE
IVASMHTSDSIYLEWLSQIKQNMAGNDNLFELSRNALKSTQIANAHFGFQAKAAQEIATF
TQELVDHAEEEIKIAGTNLKSDSTSFVILIFCGGILYCFFIWLTSWHFMAKGIIKPVIAT
RDAMNAIANEKLDTQMPTTDNLELQQMVSSLETLKTYAAQVKTMAETDGLTGCYNRRYLD
NQILKELSYANDHNMPLSIVMFDLDNFKEFNDQYGHVNGDQCLRQIVNAAKSILQRPTDI
LARYGGEEFMLLLPSSHIEDAYKIAERLRETVIDLHIIHQGSSHSGIVTISLGVACWQPP
ESFDVNKLISHVDEALYRAKLAGRNRTEVFIDAR
>Q8EAY2|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MQLPPIPDNELQRLSTLKALNILDTNAEERFDRITRLTRRIFALPICVVTLVDASRQWFK
SCQGLEVTETSRDISFCGHAINHDGIFIVNDAQMDPRFHDNPLVTQSPHIRFYAGYPLTI
RGEYRVGTLCLIGNEPREFSADDIETLTDLGQMVEAELLSISLNTLDPLTMISNRRGFEQ
LAFQSLASCRRTNSQAALVFFDLDFFKELNDSFGHRKGDQVLYDFAHLLMAAFRESDVIA
RLGGDEFVVLLSFVKIDAVHVAIERFQSLLEQYNQQHPQQPTLVSSIGVAHWSPELDINL
EDLLDAADRAMYQDKAEHHLNKPE
>A0A259V0K4|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MIIFKDISLLPIIYELLQNLALLYTIISLFMPVILSNQLRHNYFKFYPKGILFFSLLALI
SMLVPIQFNQIPDVTVDLRIATIILTSAYLGPFNAFLVGAMTGIFRVMLGGLGWIAWLPA
ALICGPLSFFIIKQVRSHTTGMVMATITCTLVSMTIFAINTHYFHAFLYLSPLDHPNNFY
NILVALVTCNTLAAVAYDRAINNIIKHQKDYDALRLKADVDGMTGLFNHNKFQYELAKAL
DSAKKSRKMLCLLMLDLDYFKKYNDNFGHQAGDALLQEVSRFFLESIRPQDIASRYGGEE
FAIVLPDCSEYEALQIAEKIRRKIEQHQFYGCEEMPKGKVTISIGIACYPTNSADKESLI
QKADSALYAAKRSGRNKSLVYSPYGNVCFMVKP
>A0A6L6GUX5|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J316|TrEMBL
MDKPSADYSRPSFRKALVRISVISVVTTMTVAWLFISATSMLSFRQYADKNLQLMAHTVS
YSLEAAVVFRDGNAAMETLKELGKQGQFSSAVVTDIRGNELVRWGQDDDSLLHKDPLGGM
VSGWLFPQPVEQPILHNGERIGTVTLIGEDATVTDFVYRSLGVLTICLLLASLVALLFTR
HLLRRLIAALKNITGVVHDIRATRDFSRRVPPSQINELHLFGEDFNSLLTEIEKWQQREQ
QERASLLKRALHDPLTGLANRAAFRSALESVLSDSTRKTHTALLFMDGDNFKEINDTWGH
AAGDEVLLAIAGRLSDCAGNTHLVCRFGGDEFAMILENISHDDEIQAVIDDINGRMAEPI
HLQGGERVVMTLSIGRAVVSQAATVEGVMEAADRSMYLEKQQHHQRAVS
>A0A1U1E8Y2|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVAFVKLA
WLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLF
AGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVVVVDLN
LFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPDIDYQRA
VEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAKKAG
>A0A1B7K1K4|diguanylate cyclase|EC 2.7.7.65|Kluyvera georgiana ATCC 51603|TrEMBL
MRPMTASTAASSGWWARLTRRVSPERVVNICFLVVLFFSTLLTWLETIVLEDAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMESALQVPLAFEVLHTAEQEFERKRALADWRISL
NNNRTLPLNGVSDDFVEHTNLLSRDNALLGNEFMATIELGYLLRLSAITRQHLSRFDTHM
LYVSRAGFYLSTEQDQGNSITEYYYKLATSPWFIQQSQRDNPNRGVKWNTTFSRDKVPVA
QMVTASAPLDYDQYWFGVLAIQLSVNEMTQFLMQSVEGEAEGEYQLYDRRMNLIASSEEN
PQKRTQLSQEIQAQLAYAYEHDNEGSVRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWILFTSMLLISWAVIRRMVRNMSSLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAASQQLGAPLSVIQLDLDHFKRINDQYGHQAGDRVLIHIGRVILNKVRKSDIAGR
VGGEEFCIVLPETSLEQALVIAERIRESIYSREILISRNQTLRVSASLGVCSSEELQRYD
FQHLQSIADRRLYQAKQGGRNRVCAEG
>A0A087CGU6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium psychraerophilum|TrEMBL
MNKPIEASIVVVDDEPSIRELLVASLHFAGFEVNAAASGSQAIEVIEKVQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVSRAGQAIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIETRDDNGETRKVIPLIQTKRGIGYMIRE
PKSASSAS
>A0A7W9AYI8|diguanylate cyclase|EC 2.7.7.65|Brucella daejeonensis|TrEMBL
MTARILVVDDVDSNVKLLEARLLSEYYEVVVAYNGLEAIEICQGGQIDVVLLDILMPDID
GFEVCRRLKADPHTSNIPIVMVTSLDGPEDKIRGLEAGADDFLSKPVSDLQLMSRVKSLA
RLKLVSDELFQRTGTVAEADVEALLASKMGQDYGDKDEAARVLVIDEDELAAARLRLILG
EYYRVDIACDPNTALIRAIETDYDSIVVSANFTYYDPLRLCSQLRTIERTRLVPIILVVR
EDEGALVVRALELGVNDYLMRPLEKLELFARLRTQIKRKCYNDLLRQSLNRSIAMAVTDS
LTGLHNRRYLDTHMPIFLARATGRERPLSIIMLDFDHFKRVNDQFGHEAGDDVLREFATR
LRKNIRGMDLMCRYGGEEFVVVLPDTDVEAARAVAERVRSAVSDMPFVIANGKHKVNLTI
SVGIGGLRLVGDSPDALLSRADAALYQAKKNGRNCIVASAA
>A0A2K2G2G9|diguanylate cyclase|EC 2.7.7.65|Novosphingobium guangzhouense|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A4U8GR57|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5P9EGI9|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MTFVNYNKSQDMKPSTTRTPDSELSQFRVKGEIPVPALINGLTTAAVPLLLFFSWRSMQQ
GDSVTAPFLTGFAVLLAINSLIFLFAGHKTFHRRVFITLITALFTYLATQAVEDGSAIIW
LFAYPPIIFYISEARVGIYACLGGWLAVLVLFSPIGDALFASPYNATFRLVMIIVLAFVM
VTCYILDQSRRRSKLGLIKLAKEFEYAAKHDALTGLANRREGLEQLDNEYQRYLRSGRGF
SVLLMDIDLFKSVNDTHGHQAGDEMIVLVARTLASQCRKVDTIARWGGEEFLILLPETSL
ADAYASAERIRQAVSSQTITVDGKVIRATISIGVATIQGSESIDRLLQRSDEALYQAKSE
GRNRTCQASVAA
>C6D9C2|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum subsp. carotovorum (strain PC1)|TrEMBL
MNELLNVNEQRDNDELDYNQVITSEWTQLIATTSQKSFNLLRAISEQKASDFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNTGEHLVDLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIITETDEYIRGYSTTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTPLSIAMIDIDHFKTVNDTYGHAA
GDNILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIHL
QNGESITMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAQEE
>A0A3V8KLG7|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W5LVZ7|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK377|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAADGYEALAICDRNQVDLILLDIMMPGID
GFEVCERLKANPKTAHIPVIMVTALDQSADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRVRAESAHTMGLDELMRTGDGRVDEAGQVLLVDSRANSQERIIKTLKPVAD
VVAISDPQAALFEAAENAFELVIVNANFDEYDPLRLCSQFRSLERTRFLPILIVTEQGAD
EMVIRALDLGVNDYIVRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
NNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDQVLKEFANRVRST
VRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAIESTPFLLKSSGETLNITASFGI
SSRIASVITPDQLMKQADLALYEAKNTGRNRVVASAA
>A0A8G1NJK4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MSLHPVRPKILGFISEEVSAWLVAVLVLLAGGILTGLLAWGTLNQFHSQLRQRFQLLANE
RYSRIEERFQDQEQRLDGLRRFFANSESVSRAEFDGYTHPLLLRTQAYSFALRVSGAERA
AFEQRARDEGLSTFSVRELNARGELQLASARDEYVVVLYSQTQSRLGAPLGYDLLAQPLR
RSTLERADQLRGLAVSQPMHLVGIEPAYARGVLLVAPLLRKGESRSYGYVMAVISMRQLL
ADGLPDALHDYLSVRILDLSTNDQHEVLFESTNEPVPSDLSATRLVRMADHDYQVDILPS
EAFMQANHSAVGSVVVLGGLLSLLLSALLYVLVSQRQRALRMVELRTQELHEREQELRGT
HGQLRGVLNAATQVAIIATDLRGVINTFNPGAEQMLGYHSNEVVGHMTLENLHFPRELVA
RAAELSARYGKTIPTCQAMLVEGGEVGGHEAREWTLVRKDGSHIPVNMLATPVLDEQGLW
VGHLAICIDITERKRVHEALAARDVLLKKLSAHVPGGIYQFKMEFDGRFSVIYASDGIRE
IYELEPDVLLLNAEAIFTRIHPQDVSRVRKSIRASADNLSPWREEYRVQLPGRGLRWVRG
EATPEELPGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLTTEMARV
ERGGGELSVIMLDIDHFKRINDQYGHAVGDRVLQAVCERIGHRLRRTDVFCRLGGEEFMV
LCPDIDGDHAHMLAEELWHSLRSAPIDVVGVVTASFGIASWRPGEGADALLLRADSGVYA
AKQGGRDRVERQMN
>A0A377ZEU6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVVFFSTLLIWREINDLEEAYVANQRNNLSNVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A7M3GNC4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A8F2F3M4|diguanylate cyclase|EC 2.7.7.65|Christensenella sp. MSJ-20|TrEMBL
MKRRFDRIGIFRRMAFYLAMALGSLPFFCVAQAQEQDGERQVIRVAYPVQWGLTQYDEKG
GFSGYSYEFLQEISQYTGWEYEFIVINTGDINQDLTTACELVARGDADLIGGMVYSDQLA
QRYEYPVNSYGSSYTVLSALEENAEINEVSYRHYPNLRVALYRGSVMRRQELETFADTQS
LSLEYVECGPMEESANAVREGKADVFLTKDISMPVDMRAVARFAPSPYYFACTKGRTDLA
GQLDAAILNIQESNPHFAASLYAKYFNAERDEIHLSRDEADYVKAHPTLRVALWPFQSPL
QRYDSVKGEALGILPDYLRLVGEKIGLTFEFVYMEDHRALRDAIEEKQVDLVAGFYHDYD
LAGSYGVSLSQPVISAQVVLAVNKSVKADGLSERIIALPQGYDFLNVYNSPIRLYPSVEE
CLEAVNSVGEADYFFGDVYTVQAITNQRYYSNLNLIPQAAILQEFCVGVVRSASPELLSI
LNKAQRGVSQGELQAIIYQNSGLQSGPVTLEVFLASNWQAVMVGVLAVCGVIILLLLQYL
RRRSRVNREISLANQRYKQLSALSNEILFEYDIPRDRFTMSDKGGQFFGVSSTLEGFSRR
VKDRMDLGTLSLSDLLERLEQGGGTPIDIQVRLGEDDFRWLRVVANIIRDEGGNAVYALG
KAMDISSEREAQEMWKEQAQRDGLTQVLNAGACRQAVREALADPEFQGGALFILDVDDFK
SINDQHGHYVGDRVLMELGEVLQSQVRHEDIVGRLGGDEFLVFLRGVQDREMVRERCIRI
RERMRDLISKWPISFSIGVAMVGEERDFDALYRRADQAMYTVKNKGRDGFEIV
>A0A8F2JC77|diguanylate cyclase|EC 2.7.7.65|Christensenella sp. MSJ-20|TrEMBL
MGEKREMTRLERECMEFILKVQGLYFNKRDLLGVLQLMDPEICWIGTGEKEICRGREDAI
RLLSAEAQGYQGTFDVLGYKYDVQELAPDLCLVQGSIALQERENDQSLNLMVRVSLLCVR
KGGAILLRQIHMSTPSSDQLDGDFFPRGLSAENVESLRRLLNERASQLEERDRQLSSITD
SLPGGVMSCSVTPELQLIQYSQGFLDLFGYTAQEVEELFQGRFMEMVHPEDRETSWKTAQ
AQLAREDRQELEYRIIRKDGRPLWVLDRGTLVHKTDGQRYLSCILLDIDRSKKAREELRL
RLEQYQIIMDQATDVIFEWDIAADTLVYSSNWEKRFGYLPVSQGIQEGIPHSQHIHPDDL
DVFLDIMHRMASGEAYGEAEFRIVNQAGRYLWNRIRATLLTDGQGRPYKVVGVVIDIDQE
KRQTQRLLAKAERDTLTGLYNKGTTESLMEQRLTQIEKASGCTFLMVDVDNFKLVNDRFG
HLSGDAILSEIASMLQGLFRQEDIVGRIGGDEFAILMTGSADPYAAQQKAQDILNAFGRL
LPGGVGEGKRLSCSVGIALAPQDGETFQALYHNADLALYRAKIMGKNKMAFYSSDLYTFG
GPNLDLAASPPQAAIDSDRATGAFGRPLADYVFNSLYHATDIEVAIPRLLEIIGRRFDVS
RVYIFEDSPDGLSCDNTFEWCAAGIVPQKESLQRVLYEELGDYYQNFDERGIFCCQNVAR
LNDQKLKRILEDQRMKSVLQCAIRDRGKNRGFIGFDECRNNRYWTQDQMETLSFLASLLS
VFLLKDRAQSRMELCCAIK
>H6RTL6|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MVLLDPDRFKEVNDTLGHHVGDTLLRSVAQRLTDELREGTVLARQGGDEFVPVLRDCSGE
EAVQVAGRTLDAIRSPCQVEGLTLEVDGSCGVAVHGTSATDLLRHADVAMYAAKADHLGV
AVYVPSMDADAAAQLSLSGDLRRAIRDGELVVHYQPRVRLDDGRVVGVEALVRWQHPERG
LIPPDQFIPLAEQTGLVRPLTEAVLDQALTDCRRWRDDGLDLVVAVNLSARSLLDPCLAD
QIAGLLRRHGLPASCLELEITESAAMKDPGRALEVLQELRGWRPARPGRNSAGWGAMSPR
ATGWPGRSRTPPSRDPWPSSRTGRPARTRADHRAGRRPDRKTAGRGPPARDRSGRPRRCA
VHLRRGGGDRRRRPARGLPPRRAPDGRRLGTRGVRARRGRGVRLAGPARGRAAGVRRRPG
EHAGDRRGPDGGAAPAGLRHPLPGGVGRDRRRRMRVLLRHAARPSRER
>A0A1V5PGD5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin356|TrEMBL
MKKSILVSSAVFSSIALSHKARAFTSDGATLNFQTVHSNYISSVDVIGVIAIIALAVLSI
MLYKRAKALSKATHALENFNELRQTFIDAYPGYIYLKDENLKYVFVNKNFAQSVGLSTES
IIGNDNSIVFEAKYVKEFSSTDLYALEQHKLVEGSAAIGERHFKTIKFPVRMQNGAFGVG
TYIRDVTQELEQLREQERALKRNELLYDVLSKHFNSKQEQLDYALHELLKLSGSEFGYIY
FYNEEKEEFVLNTWTEGVMRECKVKGEPKIYKLDKTGIWGEVVRQRKPIIVNDFNKPNEL
KKGYPEGHVALKRFMSIPVFIDGKIVAVVGFANKSAEYSQEDVKEISMLMSGVWNAVERR
EANEALSYERSKYLKTLLSIDDGVTIIGRDRKIEFMNTVACRLTGWKLEDAVGSNYLDVF
SLSYEEGRAASHNPIEMAFSTGKVQALGEQIVMKSKTGEKYYLEDSTSPIADEKGAVAGV
VLVFRDVTEKRAQLKHIEYMSFHDALTGLYNRRFFEEELKRLDIGRNLPISILMGDTNNL
KLVNDIFGHSFGDTLLTKITEVMKNSCRADDILARYGGDEFVLLLPRTSSDEVERVAQRI
KKGISFQRVSAIGCSISIGYDTKTVESTDILRVLRNAETNMYSAKTLERSEVEKRELEAI
IDALHTSNKREMLHSKRVSQMAKRLGKALKLSEADIEKLELAGRFHDIGKVVLDPSLLDK
GHEFNPKEQKERDQHPIIGYRILNYFDDTLELAEIVLAHHENWDGSGYPKGLKGEAIPLL
ARILSIAGAYEQMMHPSTNNEAKSLEEAVLELERELGVLYDPIIGAAFIELLRSA
>H6RJ52|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MSPVPIEISTVRRRRRGFRLTSRVFWDLAVWMIGLGIAVGLVFPPFATGLGVPAEYAERP
LFQAACLGAGFLVGALSYALCRCLVGGRLAVLSSHLRSVAQGISQASRTGDWAQSTSQRI
RVDSDDQLGETAQAFNSLLDALEAGEHFRSLVRNASDVITVVDPAGTVTYQTPSVGWVLG
YPPGTLIGTDIHALVHPEDARTFRDQLASVVRGPSPAPCPAVRIRHRNGSWRWTETVVND
LLDDPAVTGVVLTTRDVSDRRELEEQLRTQAFYDPLTGLPNRALFMDRLRAAEELERDTG
TPAAVLFLDLDNLKTVNDTLGHDGGDALLEVVAQRVGACLRPGDTLARLAGDEFAVLLGG
PQSGEMALRVAERILGALREPVLVVDRMVRAGLSIGLATTATAGVSGIGLLRAADIAMYV
AKTSGKGRCEAFQPSHHADHLERERLQAGLYQALERHELVLHYQPIVDLASREINGYEAL
VRWQHPERGLVPPAQFITLAEDSGLIVPIGRWILREATRQAAAWQRIDGRAPRMSVNVSV
CQFRHPDLVDDVTEALRASGLAPDRLTLEITESLFAQDTTGTTLKLEQLKALGVRLALDD
FGTGYSSLSYLRRFPIDILKIDKSFVDGVATSCEDRAVIGAIVALGQTLHLDLVAEGIET
AEELAALEALGVQSGQGYHLGRPAPPQYASPGAERRRSGSPGTALRSAPAPRAATAASPG
QDDPVREAASPGHS
>A0A5J4EC61|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg04|TrEMBL
MTENEDILTTSRQIRWLYALFVALLGAFLFLRLDTGGSGKLVAAFFAFGLLTVALVWRGD
KDNWSLPLLNFAAVCVISLSVWRYGAAAGLNGLVVLPLLAVALRQPPVFFVALLLFALLS
QGMAVPDWSSRYQLVQFFLPGVAALAIVMFQRKQKDSLDKRVAKLEILDMLTGVHNIRAF
NNFLQHTHRLAKRHGNVYSVVAVDLVGLNSINQKFGREAGNGCLQCLAEALQEVMRTTDV
LARAGGGEFLILLPATDHTGAGLSIQRIRERIASLTYDAKGSVMHLAVHAGMATYPTDQQ
EPAEIIDHADRQLELDRNLRHKSQPTWV
>A0A8F9WZH5|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVAGAGIWFGAIYALVI
TLLVLFVLGSLLLWFQTGSFMASAGAESLQVLVIWGIALLLFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETERLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEENMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAEQFLNELENEMMMNEL
>A0A8F7NBQ1|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVAGAGIWFGAIYALVI
TLLVLFVLGSLLLWFQTGSFMASAGAESLQVLVIWGIALLLFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETDRLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEENMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAGQFLNELENEMMMNEL
>A0A7U7EPB5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas carbonaria|TrEMBL
MNERRSRNSAKPGLSFVRRAFLPRAIGLAVGFFAVAGVLWGRAEPLWLWGLLALYCYVWP
LVAYRIAIRSAAPYAAEQRHVLLDSLMGGFWIATIQFNVLPTVMLLSMLAMNNTATGGAR
FVGLGFLLQLVGMGLSVLLFGFGFSPQTTQQHVYACIPMLVVHPLTIGLVLYRLAIQLGK
HKKALRELSRTDSLTRLFNRGYWKDCLQIEFDHCRQARQMASLALIDVDNFKATNDQHGH
VTGDSVLRTVGERIRQSLRSEDLAGRYGGDEFCIVLPHADPALAQEILERLRGEVAGLRF
AEAPDLRVSLSIGVAGFDPRLADATAWLRAADHALYEAKRLGRNRIVLAPAEDDGTVRMS
DSAPA
>A0A0B0I5X5|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. P1XP2|TrEMBL
MKRCLASHETVCGDIGPSGRYGFAGRTVCLVPILSRNGQLLVAVLACVLPKDGSSGGTDA
VHATALHYRSCFFRRYEYIFVSDVMKVQKNAEREASRRSILFQIMQRMHDQIDVDTVITE
VLDSIAILYPSIELSLMMSQDHEHHNPRVRPLVFHPWGEDICVRAFMDGRLTVQEGMEGR
DEAEIAIPFGGKQGIYGVFHLKMTRELKEDLDLQLITMMIDTAGNAFENAKLYEQSNLLI
HELRLINELTQRLNQSLQLADIYKLATGELLNIFNADYCCFLQLNEERNMLEVMSCNEPS
LSRDLFSKDYGFGGLVYEKKEPIILSDYHLNTKVSSKLMEVTGSQSLIATPLSVNGKVIG
AVLLTHRSPHFFSYDNYRLLQTLASHIGLSVSNALLHAELRRMANRDMLTDMYARHYLDE
AIQDSQAKDFCGSLIVVDIDQFKQVNDTYGHQKGDKILKQVSEILKTSIRPVDIPARWGG
EELAVYLPQLGLHQAMKVAETIRTRVARETNPGVTVSSGIAEWCILDKHISVDSLFYRAD
MALYRAKNSGRNQIQIEDMSE
>A0A0B0HZJ5|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. P1XP2|TrEMBL
MFDDLFQENTQYFNSILIADHNRVVRAISPHTTGVIVGDKLTSEQSMKAVTMKKTFVSEP
YRATTGRLIILISAPITDKNGNYKGFVGGTIYLEEKNVLSTMLKEHFFGDGTYVYVVEEN
GDLIFHPEQRRVGQQVLQNEVVRKVVSGESGSQKVTNTLGRVFLAGYAHEPSSSWGIISQ
TPYEVIDKPLRHLVNRMLLFSLPFLILILVLAWWGASRIAKPLHTLAKFSDEATLKPVPA
EDIPDIDSSYYEVRLLSQSVKIALQNMNQDLTHLRHEVNIDELTGLVNRRGFDSVMAGWL
KSNVPFALILIDIDHFKQVNDTYGHIIGDEVLRYLARLMQLVASEEDVCFRYGGEEFGIL
IRHCGLGRAKDLADRLREQLAMTKSPTGQPITISAGISASPAHGHSAEQLVMRADEALYH
SKENGRDRTTVSRGA
>A0A3P8IZ40|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLLKELIIFDLLATPVWVVHPFKERILYGNQASRALSGDMSLDQMRKGTFSTCPEVSLQN
YLYYFKILPRFLKSGQLTPPTARPRFIVKPR
>A0A752IEQ0|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A518CGR6|diguanylate cyclase|EC 2.7.7.65|Polystyrenella longa|TrEMBL
MIDPKKIWSSNNLPSLPMVAIELLELSKDTDSEVSDYIRLVKSDPAITAKILKATNSSYA
GFKNPITSIDRAVPLLGATVVTSLALSFSLSDAAHVAGPMATCFKNYWRSSVVKAAACEV
IALEYNPGSESDFFLAGLLSSLGRLAMLKTIPQDYLKVIETFEESEDKLLHEVETELLGV
NHIEAGLNLMISWKIPSTIQLCVRHQADPPEVINAIEPSQDLDMVRAVAVANAVGSYFCT
HQKGIALQRLQLLTASFYKWSDKDLEDRLLKMKERIDLAAEVFSVDTSEIESLNDIMAEA
GEQLAMLAMRAHVASTQAVVRQQIIEEEVKQLEQKNQELTEQAIRDVLTGTYNRKFFDES
LRKEIARAARSATTIGVIFLDIDNFKKLNDTYGHQFGDDVLKQVSARMEDTLRTTDLLGR
YGGEEFVALVSQPTKKGLTKVADRLRAAIESLKILFNNKQVPVTISVGACIAMPRRNGLE
VGERLVTESDAAMYDSKRNGRNQVHVRSIIDPIQEQLTQLSNQKRFSRWLVRHGHARIEE
VSQVLLDCHFPHEKIGVLAQNSGYLTAEQVEQILDLQRQSDERFGVTAIAQGFLTEEQVA
YLLAMQQEDAGQVAQALAAKGCINDEILYNLMNIYKHEVDPSRPAKNAVASDSAT
>A0A0N7LU23|diguanylate cyclase|EC 2.7.7.65|Thalassobacter stenotrophicus|TrEMBL
MTSTVSLGFDALDGLMPMHILIDKLGVIMHAGPTAVRLRPEHDLLGMRLFDVLTCVRPAC
DGGFEDFRQVIGQPLKLQFRAAPHTRLRGLLHPLDDGQLLLNLSLGYSVVEAVSDYALTS
RDFSHCDPTVEMLFLIEAKSAALSESKKLNARLDEAREAAQTQAETDALTGLHNRRAMDQ
RLCDMTQSRRRTEFGLMHLDLDFFKQVNDTHGHAAGDHVLLKVASILREETRANDLVARV
GGDEFVLIFPDCTDVTLLDTIAARIIARLEEPIPFGSKQCRISASIGTTISSLYSEPDPD
RMLSDADTALYQSKNAGRARHTLFKDAFEADDMVAH
>A0A653ZIZ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MPLRYRHAQMDQILSILSETIPKARTLEQLTRPLLSLLSQATGMESTYLTTIDTDAGVQR
VEFARNVGDMVIPEGLVVPWEDTLCKRALDENRMYSDNVAECWGDSEAAAALGIRTYASA
PIRSQDGRVLGTVCAASSDQVARAPDVEPLLMLLSGLLSYSIERERLVERLQAANSELAT
LAMTDPLTGLSNRRAILNDVPRLFDQALRESTYVLVGVIDLDGFKQINDTYGHQAGDQFL
CGVATQLQHCLRSSDTIGRVGGDEFIVIAVSTPSEHLDLKTDMQHAAGLMQDRLSKATIG
QYRLGPELDDIDYTGASVGVVAVLPGSMTAEEAVMLADREMYTVKQQRKRQRL
>A0A4P6WN62|diguanylate cyclase|EC 2.7.7.65|Citrobacter arsenatis|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVSQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALAQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKNLRSERILKK
>A0A5C6AWZ4|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MLFDFVIAVSFVSTGLCLGWVAHALYRAGVLSSPAVSAPAPESSNVEATSVVDSVATALA
PEQVTAVADRIRSFAATIAASIDTHQTKLEAVSSTLSGTDLTQAPPGILEAVEQLLSANA
SMRQQLQESQERLREQSKQLQSAEQRAQTDALTGVTNRGEFDQRIGKRFALGPSQAGVLV
LADIDHFKRFNDEHGHRAGDEVLRQVARGLEARLEPYGTVARFGGEEFAMLIEPESLNTP
GDFDEILQLVEQTRISVSTREIQFEEKRLKVSLSVGIGELQPDQTLGEWVQKVDDALYRS
KECGRNCSHYVSADRIIRVASPSPALAGTMPEHSLQANGASGSGVATANRSVVDGSVATL
ATKWQPANVDESVDHHDPLRSLMLTLDSTESTERPKTLGYLPDQETLIEGVLSTLQTRRL
TNRPHYFVAIQLSGNPSGALMRSLLQLVRAAMRSQDRIGCINHNTLLIHLPECDEADVNQ
RAEQICLSAGSIGVQLASIDREQQSERLSIGINRLDFLDELSVSARKHSGSSGLPDANQI
REAIVQSRAVALLAARQPAGAMPIYVREAMLESMA
>A0A1V5QBW5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MKDKRRFTDNFKHYVNELQKGNSFFSAEIIFSKSVLVFAFIDAVKALLFFLSNSLYMMIV
YGLTCVLLITVAHGRIKKGHHLSVIMIVLLEISVMSVITTVFVGWDTGFSNLLFACITAS
FYFPLVVKTEKRNMLSLCFCILILLCYFVCYLLTSILIPITPLSRSWTILFFIFNTLLSM
ALMVTFSFLFVWELMSKQRLLQQQNDQLDELAHKDPLTHLLNRRSMNELIETHMDNLKKT
GRRFTIVLGDIDNFKSVNDTYGHEAGDMVLVAVSEIISRNVGPSDLVSRWGGEEILILLS
DPLEAATLTTDRIRKRIDENIVSHEGQDIHVSMTFGAAESIPGFRIEHLIQQADDKLYYG
KKHGKNQVVTDLPEDFVIKKK
>A0A7Z9BMH9|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MVNFNPTETSEDQLQQEVEDLRFQLEIAKDTLRAIGNGEVDALVIAGSEGEQVYTLQGAD
SSYRMLVEEMKEGAATITTDSTLLLYCNKRLASLLKTPLKKLIGTDFKEFISPSDLTLFQ
ALCQKANSDSGKAELTLIARDGTEVPVYLSINILNQKGVDVGCLIITDLSEQKRDEDIVA
QERLTRLLLEQAAESIIVCDHQGKIIRASQEAEKILGANLLLSDFDDLIKLQLLPQQNGS
QPLRKKEKSSNSIFSITSVISGHPYKGREVLFIREDGEKINFLLSASPLSTPHSIFKGCV
VILTNITERKWSEDALKRINEELEIKVSERTAELESLNSRLKQELAEQARTQQILQDQAQ
LLDLANDGIIAVDLNDHINYWNQGAEKLYGYSKSEVLGKNLVELLKIQSPQPLEKIKQEV
FKKGNWEGEFLQTNHRGETVIIHSSWSLKQDREGNPIAILKINRDITKSKQAEQAIIDSG
LRLAGILDMAQDAIISINEHQEITLFNQGAEKIFGYTANEILKQSFNLLISEFLSEEDCQ
YKTELSDNNCLIKHIGEYQELTGRRKDGTEFPAEVSISQLFLEEGKILTVFMRDISDRKR
VEIAIQKAQEDLEIKVQERTIQLATSNDDLIREIAERKLLENQLHEINEELEQRVEQRTN
ELAKAIKDLKQEAIERQKTTLALQESEARFRAAIDGSLDAFFLLQIHRDQEEKSTNFVLV
DMNSKAEELISQNKDNLLGKELNYVFYQERNLGYFDRYLRAFKTRKGFEEELEISNPNIK
AKWLQIQVVPLSDGIAVTCRDITERKKTEEAAQQANENLTRWVNDLEQRNRETMLLGQMS
EFLQACNSTEEAYQVINDLLKPFFPKISGGLFVARNSKNLVEMVATWGELQVISEAVFSP
QDCWALRRGRSHFVPATTSNLLCKHIHQKNCRQYQLNSNNSSKITLTSPTKTELPAYPMM
VEHLCVPMIAQGDALGLLCLASEESGQLSGDQQRLATAVAEHIALALANLKLREALEYQS
IRDGLTGLYNRRYLEESLEREINRAQRQKFSLGIVMIDIDHFKNYNDTFGHDAGDIVLQQ
LGNILQKNVRGSDIACRYGGEEFTLILPEISLELVKERAEQIRVEVQKLKIKHHYQDLGQ
ITLSLGISMFPNQGLTGESIMRAADTALYQAKEEGRNRVCVFGSNFDHSA
>A0A7Z9DUM4|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MIMVWMKKLFQTSMKSRLLSEAELRSVFAAMSDLVLTLDDQGRYLNVITNQPQLLYKPID
QVLGKTLDEVFPEALADYILQMIQTALKTQTTIPLEYSLEIEGKNIWFSANISPLSENSV
VVVIRDISDRKQVESSLQETNLALAEAQKLAHLGSWSYDLINQQIHWSEEAFAIHGLSSD
QQIPSYEELLQVFTHPDDREIIRHRMEKAMDNGEQFNQEVRIFHPDCSLHYILIKCQGVS
NQQGKIIKLFGTILDITERKQIEETLRQLLKRERVITEITQRIRQSLNLEEILNTTVIEI
RKLLQTDRVLIYRLEPNQSAKVIVQSVGVEYISPLGEQIPTTYLTQGQCIIPFSQGCLHN
ISDIYAAKFKSEHLEWFERYQVRALLGVPIIKGEMLWGFLMVHHCASPRSWAYWELDLLE
QIAAQVSIAIHQSQLYEQTQAQARWERGLRRVIQAISQSLELTTIFSTATFEICQLLGVD
RVSIAQYLPDENDWLVVASTPESPDIPDTISREIFDKNNLILTQLKQQKVIRISDFQQEL
SRPVNQDLADNNPGSLLIVPLWIGSSIWGSLSLYRHHQTWIWQDTEVELACTLVEQLQVA
IKQSQLYEQLQIANQHLQRLVMIDGLTQVANRRRFDEYFLQEWKRAAQEQQPLGLILCDV
DYFKNYNDTYGHLAGDESLIKVAQVLCETVCRPGDLVARYGGEEFAIILPQTSVKQAIQV
ADMIIQNLESLEIPHQTSLISSNLTVSIGIASLIPSVDSPFQVLIEATDQALYQAKAEGR
NRYIVYNGE
>A0A1V5Q5S7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MDYNDVACKQKRIAAVLSVRIEPDGGRGEICLEAANDIYLESVNVKREDFVPGKPYYNYV
PKDRNFEEMSYSCVRECRIVHAYVDAEFYHSWMEVVMMPLLSDEPDKEYYLFSYDMHAKV
DASRLSDISPDIAVNVIRTSLRLKEAGDFHMAMDSIIRDIRELCDAKRSCIILTDFKNRT
CSMLCESVDETEVIAPKEVFLSEGFFRIVEVWDKLIAGSNCYIIHDEKELELVKSVDEDW
YNSLKNDKVYSVVLFPLRSNDETIGYIMSINFDRERSEYIKTLLGVTSFILASEISNHQL
FNRMKFLSDTDLLTGIYNRNAMNNRVADIVNGITPIRDSFGVIFVDLNGLKVVNDNEGHA
AGDRLLKRASCVLKDMFPCAEIYRVGGDEFLILLTSENEEAFNRAVKDLKDRVEQPGEVS
MAVGACFGLGDMDIREAMHIADEAMYEDKKEYYRRNNIKNVRS
>A0A174ALR6|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MDRTAVFNIAFEMWGILICLFAFVVIFLQKNNNRDKKNVSLCMEAACIILLAADMLSWYY
QGKTGQTAYYMLKISNFAVFFINYLYMTLFTFYLLVILNRGETKMPAKARGVVVLSAAGI
VLLIISQFSDKLFYYIDDNNFYHRSSCYLLSQLIAAAGLVLSFSILLQYKKRLEKRVFWS
SVLYFILPCISTVVVIFYYGISFQTISVVASTQIMFAVDMVEMDRSLARSRQEVERTKYE
AEHDLLTGMYNKTAGMQRIREYIDNMTDEDSASLVFVDIDDFKSVNDTYGHAVGDYWIEK
VAKFLRSDCYEEDVACRYGGDEYVVLHKGLSDISVLESKVIRFARKLQRKTMERGQNVHC
SAGICQINGSGFSTEECMNVADTALYEAKKKGKNVSVIHSINRDGTDRVTVLDKIESDIK
KAQSRVEARIAYMYTDIIYVNYENDKYRVIKGDSELNNAVSCANNYDEVIGLISNRFDSD
RSRKIVRDFLSRERMESYTGGNTEYQTENFLRGVLSVSCANNHGGASLIHAIPVEEDGDR
GYFVVVQDLDIYAG
>A0A8E5U6L4|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF14523|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1T4SXJ8|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MLNNKIKTVSGILILSLITSLFNLHINKEKLKNEMENLFRYLGDSIYRYQISVINTDEKD
HRYIVKNKNLLLTPNESNNIKLLSENIKELIKVSHENTIIGNNLWTVANIFPGYMYIYPY
KKGYKELMDKIQEKNSYFNYLLDVEKIDSHLGNDNLSVYETIKVYGPYFEDITQEELITI
YYPLYNNKIVESILLLDIKYDFLHEYVMNYSYSNMTALKLSSDVGISELIFNIIAKQNNK
DTVNIPINVDYKLLVLLYILCFVLYSIVFLIFHLFTRNKKDNLTGFYRKDFFKKTRKTDC
IVVIDIDFFKQVNDNHGHAIGDLVISEVSRRIRGLIRKTDIPIRWGGEEFVILFDGLLYE
NNLATKLNDLLNIVSNEKIENLDITISIGAFITSKKINLSEAFNYADKALYESKNTGRNK
YTISEYQ
>A0A0T9LPT0|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MSELESLSTLYRDACVTYATLSISYFALSRNSAFSYNGDVWKRILFGLTSGLVSLYLNQD
QWVISGAFFYSFELIPIILVTFYGGWLSGLTALLINFAFTGWLTLDNILITIIFIPLILS
RVWERKSNRIFYTIIFAIAIYRIVAAVFVVPPTLTWAQIVVYQLISALCLAICYHALNFK
ERHIYAYFSMKNRVNIDKLTQLNNRASIDYRLTAIHNSRQACGLLILDLDHFKSVNDTYG
HNGGDLLLTEVGKLLTSSIRDEDFVGRYGGEEFIVITRRHEPQTIKAVAERIRQQVENLA
VVLPDGRKIKATISIGASLYLPGMSMLKALKMTDEALYQAKKQGRNQVVYSRLMPFSPLG
DNINKEKRRRKS
>A0A5Q0P2P5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter wanghuae|TrEMBL
MNNECMALLAEQWKHICQNYSSDDLLHAFQFIQEHSLVLVEEFYKNMLLEKESAEFFSDD
LIQQRLRDTLNQWLLESFSVGINKSFTEAVKKQRMVGHVHARVGIPSWLIMRGVREIERK
MFELLSEAEYKSALTTCSYIVQIMGFATEIMCRSYEAKTVANQEVKHSYRLFSAMQDVAV
QKDKQRSSLLDWENDLMFKVFSGGHNFKHPMLSKSEFGLWFIHKASYAFSGSDQVQLIID
RIYQVDQLNDVVVQCVEKEKILTLIQSIRDLNREIQLLVDQLFQVSEYIESGNDALTQLL
NRRYLNTIIGREITFSRQNRTPLSLLAIDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDLERAISVAESIRQYVEHGMIATSQGQQFKFTVSIGCVL
FDGHPDYQKFLDAADTALYAAKNTGRNRVYVAQSTLQATLA
>A0A1B1NSU3|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTLYKQLVAGMIAVFILLMVSVFLIEFNTTRNNLEQQQRSEVNNTINTVGLALAPYLQEK
DPVAVESVINALFDGSSYSVVRLIFLDSGEEIVRTYPVQPSNVPDWFIKLGLFDKIHDSR
VVTSGWMQLAEVEIVSHPGDAYAQLWKAFEDLVIVFCLVLLIGLLAISFILQRALKPLRM
IVEKMEQVARNHFGEPLPRPTTVDLISVVDGINSMSAQLELSFKAQAKEAQQLRQRAYID
PVSNLGNRAYYMSQLNSWLGEGGYGGVALLEARFIKELYDEKGYEVGDNMVRELAEHLKV
SLTTNGIVIARISSDEFGFIIPNIDDDELKLLAQSIVTYVQNLNADPTGMAQAKASLGVV
HNTTSCSASEILTMLDNSLAQASSNPELSFGYTTSDDSRTLMGKQQWKLLVEEAISNDWF
SFRMQPANSSSGQTYHYEVFSAIEHDDKRYSAPQYLFALEQLNVSHILDQYVISAMLDKI
RHDNLTSPVAINIARGSISQPSFIRWVSQKLNKNKDIAQLIHFEIPEDCFVTSPHHCALF
CNAVRSAGADFGVDNYGRNFQSLDYINEFRPAYVKLDYLYTHHLEDEKQKFTLTSISRTA
NNLGIKTIASRVETQTQLDFLSEHFIEVFQGFIVDK
>A0A450CH86|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MQNHNYIKMLNKKVEVLSKELDSRNFKLKTLNEIDFFSKIPNREFMYQYIDDCISKNIHI
GIMLLNIDNFKLFNDIYGYLVGENLLITLTQNLLHFIPESKGIVAYLKGEGFLIVLPNVS
NKELNNMGATIIESARELKIRLPNEKEIYSNVTFSIGSTIWNGEPNMTTLMLFNQVYSAL
KKAKSEGKNRYILFNFKDNSFYNKLENDKEFLSEISYVLQTKQIEVFYQPLYNIKNNTIV
GCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDLHLFEENCKNIRKWIDKNDVFVPIC
CNFSRLHFFNPNFPSMLKGITEKYNVSTSNFSIEITENILIENTNTIIQQLTELRSYGFS
VSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLSHNLNDFKNTTILYSIINIARALGMLTVC
EGVETEQHVEFIKSINCDIAQGYYYAKPMECKEFEKLLSKENNSEKMFIKYSDIGKSLIE
KIFDGFFIMQDMKKLRANVTEDIQWFDFYNKTEITSFPKVIEHFEKHIKGKKFSILYKSI
TPHNTESDSLLISGEAVLSDEAAKHQKYSNFYFSANCIISENKLLLAKLHLDLIKTAGYI
NEFESYSIPKMTNTHLDESNVLSQFYSMLPVGIIRYDLFGDMIITYINEEMFDIIGYTKE
QFFGEMGGNLRAIVHPDDLDFVYKKSLDMIDTNKIEPFLYRFIKRDGQIVTVMYTQCNLS
AIDGRSIAQGMYIDINKIKNLTKI
>A0A7Y0LT75|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAG
QYEIPSCDINNDIFEIVSEYENRCMVLGKYTVRTKENAQMILEVNQRCTFEIIEDREKLL
VKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDS
TYSFFYVNEGLPKILGYTYNEFMEMSGGSAVGAVYPPDLPKALEDCEQCFAKGPTYSSEY
RIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNIT
DIMFEYDMENDNFIKYQRVEIDKKIELENFETKNYSKLLESGKIIHLDDIGKLLEVLRGN
LHETIEIREINSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQ
RDPLTQLYNQRVSQNLIQEYLCSSDSKNNDALLIIDIDDFKTVNDTFGHLEGNEVLVAVS
KILLHNTYDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIG
IAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSVYE
>A0A212KBG0|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MARDGMTPACEGDEVLLQLLDREGSILGVNAAWTAVLGFPAADCVGRPAAEFLDPAAAAG
FRRFFEALPAPGATPYHHLVLRDREGQAVSAVLSARILEAGEIACEIWTLDGFARSMDRA
RRQAARDRAEAAVMRTVSAVTDLLTRTRTVAEFLRELGLLLEVISGTGRVHVETADGPPP
WMRPLAEGVRARYGEVRKTGGAVLPPAHLAAIAPLLGDVFGDAPVMALWIADATMPRGRR
HVVAALPPDGALQDSWSLHVGLFAQAVGNAISCLNAWETQARMLRQAHTQSVTDPLMRIF
NRYKLEETLAAEERRARRYGTWFSVIIADIDHFKAVNDTYGHPVGDAVLEEIAAELRTHT
RATDVLGRWGGEEIMIVCVHTRQEVAVGLAELLRRRIAGRRFAGIAGLTVSFGVASFAEG
DTAAEVVARADAALYAAKREGRNRVCECEASPKAAEPPPARS
>A0A4P8YQY7|diguanylate cyclase|EC 2.7.7.65|Jejubacter calystegiae|TrEMBL
MSNILISSGRPTFRRILQRISILSVATAMIACWLFLSIASVLTLKQYAQQNMQLLGVTVS
HSLEAAVAFRDVGEIHETLTALGRQQQFSSALVRDSEGRPIARWPATPRPRPKTPDALIQ
RWLLPDPVVQTVWYDGVPVGEVQLTAKGRLITHFIWLSLALLTGFLILASALSLAISHYF
HRGLVQALQNITEVVHDVRQNRHFSRRVKPEPIEEFQRFAHDFNCLLDEMEQWQKQQQRH
SASLRKSALHDPLTGLANRAAFREALEKVLTDPLQRTHHALLFMDSDNFKQINDNWGHAA
GDRALREIAGRLLRFSARRYPTFRLGGDEFAMLISDVTTDEQIQRLISRLGYLFVPPMPL
RNGEAISLSLSVGYALVEPDSTSESLLEIADSSMYHNKKLRRGR
>A0A653ZY82|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. AX6|TrEMBL
MTSANAIRSVGDNDAAARLFQAVGIFLRDQRLDPNPTNYTFAWHVLANPAGPLAQAVNQL
TDGGIRLTQKDIDSLGADVDTTTESATIEGLVARTQMKVETFADMMGSLHEETRGFGRDL
QASAEAIAASRERPQDGIALEEVARITASMIERVHVAEAQLESATKEANGLREDLEAARK
DARRDPLTGLPNRRAFAEAFAAQINAGSQLCLAMCDIDHFKQVNDRFGHQVGDRVLKAIG
DTMAKHCGGQLVSRYGGEEFAILFSGLTLEQADAMLTIAREATSERFFRTRDGDSPVGHV
TFSAGLIALRDGEVQSDAFHRADRNLYAAKSAGRNCIVSN
>A0A173TEH8|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKSIKKYETIINEALRSALEYDTPEGQINEFISFFGKHIGSDRIYIFEDDEEHHVTNNTY
EWCAEGITPQIEHLQGVNMEVIDWWYDTFDEGKSVIISDVEELKEVHQVSYNMLKYQNVC
KVVVSPLRHKGQIKGFFGVDNPPAVDYNALTMFLDMIGTMLISLLKIRNTFQKEQYNASM
SSYSALSEIYLCMHLIDIKTGKYEQIKNVKHVEKECEELDQENFSKRVYTTMKYFCTEMY
LSSVLEFVDLSTLDRRLMETNTIVHEFIGTVSGWCRERFIKVDSDEKGRLWHVLYCVEVI
DEQKRREKKLLYLSETDSMTGINNRGSGERKIAEFLEKKKGGLFCLLDCDKFKKINDTYG
HAVGDTVLIKLAAVLQRACRENDIVMRLGGDEFAMYLPGMPDKAQAESFFKRLFTQIDKI
SIPEMQGEKINVSLGASLCSDKDGATFDTLYHEADAAMYESKKIVGNHAIIYSDLPQARQ
TPL
>A0A174GDA7|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKEGADGILLAPANSNSLVDSCEKVRKKKIPVALIDSSINSTEFDVCYMTDNIDAGEMAA
KEMLTMLHDTGNSPQESLEVGILLSSDASQAMVNRVSGFLDYWAKYAPTKWEITKDIALN
GGDVKKAESDAAKLLKKNENIKGIYGCNNTSTVGIAKTLTKQKRTDIVMVGFDMAEETKQ
FIKDSDYRGVSLMQKQDQMGYLGIGTLNSLINGKKSEQKYFDTGVIMIDSDYLMEKKEKK
RYIGLSSTDALTGILNRRAFQVELEEQIRKKEPGFFIFIDVDNFKSYNDTYGHNNGDLCL
KHFAKAIQECFPEGSILGRYGGDEFVVYLKDVTKESVYIYMEKFQKMIADLTLATGEKVH
LSASAGGAAFPEQGEDFISLCRSADAALYNVKQNGKGAFKIK
>A0A173V291|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKLKWRGLQFEHYILGILLAVEWIMSFTFLGYIHIPPISITTAYIPIVVIACLFGPVESS
VAGLFFGLGSMYKASALYVMLGDRIFSPFQTDFPIGSILLSVGTRVLFGFLMGCIFKIVN
KSRYKWAGKSLAALIATPLHALLVYGAMGILFPESGFNYKSSFRWGVNDYAIAAICILAV
ILSDIIYHSSFVTHYKNVINDSELRQHWSVKMKMSLFIIIIFVFCIAAFSTIYFASWTEY
MFGVYGVKVTKKIAQDILHLQVQFLAAMISLNFILIVIILMIYNYMKHREYMGEMDALTN
VMGRRLFLNYCTKCQNDRDDIDNKSKRKGWFLFIDIDWFKQINDTLGHTVGDETLKQIAE
SLKNIFSSYGAVGRVGGDEFAVIINEKMTKEQLEEQLKKFLLDISAILPERTVSCSIGVY
HFGFPKSQKELLTRTDDALYKAKEKERACYVILDE
>A0A173U8K1|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MDMFFCLFCLIIFVSIKANNPKQKSMRMFVRLFLIATVLFFGETLAYIFRGNLGLFNILV
TRIANLMVFAMNIAMANTYVRFVSSVFVEKGAEVSGNSVKIANIFSCINIFIVVVNLFYP
WMYYFDEANYYHRNNSWYVYTLISLVVIFIGAGMAIKYRKYLKKRSFISMILFSFIPIIA
TVVQSFIYGFSITNLGLGIGSVVMFAAYMYDWSHNGDEHTNMINDSRFGAVIMFIIMLLS
MSVSIIACVNVIQQVTKENSEIQSRTIAQMVSAKIENELIKPITVSQTISSDIDIRTYIE
GKTREEAESVKDDITNRLVSIGNEFDYKMVFVVSDKTRAYYTYNGISRYLDVENDSHDIW
YKDYLDSGKRYIVNVDTDEDNNGSLSVFINYGIIDTNGDILGACGVGVDMNDLVDILARF
EEEYNIKVYLVNHDGLIQVDTDVSSIETGYLDNSYFGNISDDDFYYQLSKNGCYMTKYLE
GFDWYIVIRDNNPVKLDENKIILPIVLIFIAGVLIMATSFVIISMREKKAKNAYNRRYEA
SIKDELTGLYNRRGFEVDCEIIKKNNNLIEYVLIMMDLNGLKAANDNIGHEAGDELIIGA
SKCMDNAFSGLGRTYRVGGDEFAALLRGTREEAQDAVKTFDYLTENFQGNLISELSVSKG
IVVCSEHIELNFEEIKAMADKLMYADKDEYYRRTGKDRRRV
>A0A3P6KHX8|diguanylate cyclase|EC 2.7.7.65|Clostridium carnis|TrEMBL
MNYIILKNIRKFNKIILIFGILLICFSIQTKSIQAEENNVIKVGYPIVEGFTEIKDGVYS
GYAYEYLREIAKYTGWEYEFVEMSLNDAMNELKNGNIDIVAGMLKNDQSIKIYDFPEYDS
GYTYTTLSILKDNENISQSNFETLNGLKVGYFETSKVRLNNFIKFCENNSITNIDLIPYP
FQTGKELSEALESKEVDAIIDGDLLTNNNEKVVVKFGAIPYYFATTKGNTKITQQLNHVL
FKIKESDPAFNQKLYNKYFQINKEHFFILTEEEQSYINNMAPLKAIYIDNYNPLQYYDIN
TKKPAGIFIDVMNLITQKSGLRFELVRVKSYEEAYELIKAKKADLIIGAPSIYPIADENE
FTLTKSYLKFDMVEVVRKNKNNQQNNPKIIALPIGGAYYNINNDYEINLYDTFEECLTAV
EKGIADLTCGNNHSVSNYLAAGYYPNLTVISNDFKTEVSIGLAKPTNNNLLSIINKAIYS
LSEEEIKDIIYLNTINIKHSVTLKQFFFDNLALCIAVIILFLSLISIITYLLVRIKFKNL
VLSKELLLKKSQTDPLTGLYNRDAFEQSVINYLNTKNPILYGAFIIIDIDYFKQINDSLG
HKVGDDLLKDFSQLLKEFFSLEDILCRWGGDEFIVFMKDIEENNLQIVNQKLHQLCQLMN
KDISYNGCSKKISLSIGSTVIKQNLDFNEIYQQADTLLYEVKRNGRNGFKVNINS
>A0A655DAU3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYXTRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMM
GDQALIRVSAAIRDAVRSRDVVCRFGGXXFLVLLTTAEPQQARATAERIRQEVYDLKIPH
MFNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A174AS66|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MKKYICLFLSTLMFLTIFSPVNCYARDGKKVIRVGFYTMDNYQECDENGNYSGYFVDYLR
EISQYTGWEYEFIQMNYSACLKSLNDRNIDLVCGVDYSSFRTSTLDFSAQPAVTTHYELY
ALKDNDTYYYNDYADFDGMSIGVLASCNHLDALDDYAAAHHFSFEKQYFGNTAQLEKALE
DNTVDAIYATNVSHPSEKKILASLPSFPLYFVTFKGNPIMEYLNYAQTVILNVNPNFEHD
LYNTYQRDIRNYRCEFTRDELDYLATAPEITVTCDPSNAPIEGYNENTQTASGIAADVLD
LVSQYTGLHFRYIKSDSFSDALSKLRSHEINMLTALAHDYSWAEQNHALLTTPYLNSSIV
VVRNSKPQSHERDIVALPNSFNLTNSILDNPEYDTEDVVYYDTIEECFQAVLSGSADCTY
ADNYSANYLLSQVKYRNLSSTTLTAMTEAASFGLSDQCDPRLLSIINKGLACISSEQLDS
IVLQNCSYREDPSLFTLVYAYPRISIPIILAVSMALLSLLLGILLVHSRKTKEIRVMSET
DALTGLYNRRAAEDHISRQMQEDGKNPDCVRPLIGIDLDKFKQVNDTYGHLEGDALLIAV
ADTLRTSVRSSDIVGRIGGDEFVVYLSNVTDRQNAMAIAEKLCQVICGLSTMKEEWSNIS
ASIGISFADHPDIKMEELYLSADKAMYSAKGNGRNQYQTL
>A0A379S4H1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MTFQQLTWPEDLNNDLEQLNMLVRGDINSYSMEKRYYTRSGEVVWALLAVSLVRHKDNQP
LYFIAQIEDINDLKQSEQENQRLMERITLANEALFQEKERLHITLDSIGEAVVCIDVDMN
ITFMNPIAEKMSGWRQENALGVPLLTVLRITSGNNGPLLEDIYRADRSRSDMEQEVVLHC
RNGGSYDIHYSITPLSTLDGDNIGSVLVIQDVTESRKMLRQLSYSATHDALTHLANRASF
EKRLQQRLQTIQESPQHHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSGDL
LARLGGDEFGLLLPDCNSDSACFTVTRLINAINDYHFMWEGRLHRIGASAGITMINEHNC
QLTEVVSQADIACYAAKNSGRSRLTVYEPQDVLTPSRGMMPLEEQWRMIKTNHLLMLARN
VVAPRTPEATSFWLVSLRLWTSEGDVMEERAFRAGLADPALHHALDPTGIP
>A0A8B4TJ99|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MRIPANHLTKRIIIYIFICILAGVGIAGLTVFFHSSLSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPIAFAFACSALLMLGTLSSYPDWWTCMTTPVVKHNDAVIYYFF
RNIMMALSFMSSIILYYFRQRLMHSWKAHAITFMACIIFSLTIIILSWLFSSHSPWLNID
FIDDTSHTFTPLWQSITGWVLICIWFITLILLICLSKLRNIFWYSGAFFCSAYLFTLYQL
LSVTGDLDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLSKVNAQHPLSVLVSDLDHFKRINDNYGHVVGDKVIQFAASVLENHSR
VDDAAARIGGEEFALLLVNTGEEDAQAIAERIRQAVSVEQSHLPERMTISMGVYTTRNAS
VSAEECVQRADAAMYEAKNSGRNRVVVWRGQSN
>L0RFE0|diguanylate cyclase|EC 2.7.7.65|Maridesulfovibrio hydrothermalis AM13 = DSM 14728|TrEMBL
MISSYETAANLFAENELCRQFIETSPDAIVIIAPDGEILAHNTKARKLFGYQDKPILPQN
VLETYRDPADREKLLASLLKYGFVQEFETELLTQTGEYITASVNVSISELDGRKVHIATV
RDISARKAAEEDLKKSESKFASLFEAASDAILLLNKTGQLVGANQAAVKLFGYSKKEFLE
LSFGSLSPSVQPAGGVSAELFAESLSEVLEGAKKQLLWQSQAKDGSLLDCNIALNMVEVS
HEVLIMCVVSDLSEQQRIQARMKLDEIRFEALSALSRMNESSLNSIFDYALEAAVSITES
EIGYIYFLNKDETVLTLHAWSRSVMPQCSVAEIPDGYKVEDTGLWGDAIRLRRATIINDY
AGCPHKSGTPEGHVPVRKHMNVPLINEGRIVLLAGVGNKRTDYTDDDVRQLTLLMEGMWN
VVCRKRADDALRSAYYSMEQKVLDRTEKLSSALADLKKINSDIKRESIQRREAEKQLQAS
AGRLSLATRAGGIGVWEWDVAGGILIWDDRMKQIYQYDPDEFDGSYEAWTNQIYPDDRKK
VEYTLSETIASGGHFDFEFRIIWPDGEIRNIKTSALAIYDADGNVQSVIGINLDVTDRRR
LEERLRRFKRIISVTPDLVSLINADYEYVMVNDAYVKSFGKPREYFVGHNLGELIGHEAF
EACSRQKIDAAFAGETQVMEAWFDFPEVGQRFLSVTYQRVDSEDGDEKFVAIAGRDVTAM
KVAEEDRQHIFEVSLDMLCVADYEGRFVELNPAWENTLGWSEEELKCQHWIDLIHADDKA
KSIKIMADLLSGAVIRNFENRYLCKDGSWRWISWSMHADPDQEKITAVARDVTMQKRLMD
DLKRLASTDPLTGANNRRCFFDRAKEELDRFKRYGGSLCIMMLDIDYFKRINDTYGHDVG
DIVLKELVRCAHEALRTSDVFGRIGGEEFAALLVHGDARSALQVAERVRRSLSELEVHTS
GKVIKFTVSIGLTWISRDTPSIELAMKHADRCLYKAKESGRNKVVSNC
>A0A8G0UGS6|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MSPPASANAFPQFLHEPFSVLLVEDQASVRATLAGELRHVGVSEVLEAASADAALQLFKL
RRPDLVLLDIRLPGGNDGYWVAQRMREAEPGGWTPIIFLSGLDGDLDVWRGIEVGGDDYL
VKPVKPIVLAAKLRAMRRLRDMRRRLVELTEELHVANQHLNEMVEMDPLTGLVNRRGFDR
ILHSEILAARRDGVPLTLMLCDLDHFKRYNDTLGHVQGDACLKEVGRVLHDVCMRPRDVA
SRYGGEEFALILPNTPRSGAMTFARALGKLLKARAIAHPGSPNGETLTLSGGITTCVPDD
GTSAETMLMRADEALYAAKAQGRDRFFSFEMQMDTIEQRQI
>A0A7H4NGG5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQHEMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTDEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEESGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A5P9II93|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MCALCLDDDAHHDDHSDPRGGPLKILAPLQAAGRALLLSLRGRLLLGVAAVWGVLCVMLL
AFGWQSGSLLVEESNRVHLRYEAELVRNAITQKIEQRLAMLERLADALPSAAPGVLAEGH
HEALLTLFEGLALVDADNIIVDNWPTLPGRNGLSIDHRAYARHMRHVQRPHVSDPFIGIV
SGKPMVMMLVPVRDAQGRYTGFLGGLVEIERSELFEDFKHLRLGDEGHVVVATASGRLLY
HPEQRRGLPGAVSALDDPGLDLALLGWEGDALGETGQGGKALKAYRQIWPAEWVVGVYLP
LEQAFAPLASVMQRITHRAWWALGLLLPVMGGLIWRFLQPLTRLAQQIRELSLGQRHELE
IPTRMTELRRVVDVFNELEHQRLQSLDELQEREAFLEGILDASPQGMFVTDTRGRLTFVN
ESLKALLNLSSPICLTTWARRLHDKDRDAMLNAWQSSLREHHDLERQFRYVAENGETLWL
DVHTKAIHVNGEFIGLVGAVRDITQRRHEDARRRWEAEHDPLTGLLNRRGFGRRLEEAFA
AWEQAGTPSALLLFDLDHFKPVNDEGGHALGDSMLRQVAAAMGTVTRSSDHAARQGGDEF
AVLLPGCAWPRARRIAEALRARIAACSVEQDGRHWRVTASVGVSTFQRGDESGGDAVRRA
DAASYRAKAQGRDAVINA
>A0A5Y2QGY6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MFPKIMNDENFYRKAVDQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAITLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIAHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7H4PN15|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MAFVGKQHQAWRLGGDEFAILLRDVHSETEVRALCSALSEQFIPPFNLHNGHTASLSLSI
GYALTWEHTSAENLQELADQNMYRMKHQRLQQTQK
>A0A1Q8YXN4|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGGGN
>A0A6P1UYD9|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVEERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENSAIFNIVSDNKTDINGALLSDSEFGLWFRHKCVRYFNKNPQM
EEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQLAVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A2J4ZGP2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSTEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNE
>A0A5U3DNJ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQSQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDAAEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWVLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>Q6D6J9|diguanylate cyclase|EC 2.7.7.65|Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)|TrEMBL
MIATTSQQSFNLLRTLAVQKASDFADEFYIYMLKDQEASLFLSSQQVHDRLHGSMSKWIA
DILTNTGDSLADLINHQKKIGQIHARIGIPVDLVERGARRLKWHLYEHIAQVADDKALCF
DAMRFASISMDIAIEIMSKTYSQSHDLAAKNEESYRLFSILENASMERERQNASLLNWEN
AFIFSVATGTPLSSIQDLSDSDFGLWFNHKGKSSFSNIQGIRTIATIMTETDEYIRNYSH
TALLTQQDYAPLLKAVRSKIYKINMLLGSLFDEVQKLESGKDTLTLLLNRRFLPTILRHE
ISLTMHSNTPLSIAMIDIDHFKSVNDTYGHAAGDNILKRIAEILYESTRNSDYVFRYGGE
EFLIVLIETPKVAAHTIIERLRKKIENHFIHLQNGESVKMTISAGIAVYSGHPDYECLIK
AADDALYQAKANGRNRIEYAPE
>A0A162RSZ4|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MINRLIQSLFFNKTSGFLTKKQEATILYDIENINFKRMKLFLIILLIIEILFIVCVDIPN
LRNSGIYITWTDKRYFILHLLLLLVSSVGIILIKTFVKSDNGELKKIHKIIIPALTMIIL
ILISIINGLDQIKIGHTSSVFIANMLIFGAVILIRFPVNLLVYLVPFSTFIEGLIVFQKK
PALLNCNIINGTIFFIATIVISKFIYNSQFDQIYKNILLKEANQKLNYMSNHDPLTDLLN
RRSFEILAKQKMETANQFKVDAVLVIMDIDHFKNINDKFGHPIGDMVLKEVSNILV
>A0A8F7VCS8|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MLKELFLNLTILITFNYLFTLLFKESLSYKEDRPMFQLLKGTVCGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFAIIVAGRILINFNASAIFSIAAVGVIAILSAAVL
RGKKPDHKMAFVMLLFSNVIFTLTLLFLMPEQPAGALVYYWLISILGGMLSLYIIKHEAD
ARVLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRTSQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSHTSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTPDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A8F8WQG0|diguanylate cyclase|EC 2.7.7.65|Streptomyces anulatus|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVAGLGYELGCVNLVRPDGD
LVIAAFAGNAAAEALITGRVGSRTSWERRLSMGEAWDDLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASAGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQQGRLLR
TNDALCRLLGRPASVMRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICER
PHSPAATAIEALDAAYGDVESSLTHGYQADGYEGEAAPGGGPFDHHVHAVAPDPEHDDGT
KGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLADG
LGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVEK
RSRSKVHRRAG
>A0A8G1E0W2|diguanylate cyclase|EC 2.7.7.65|Leptospira interrogans serovar Bataviae|TrEMBL
MKKNLDFLFYGTYVIFPLSDLFIEVIQLQFKTQINSQIENVRVKKRIIFSLLAIILIFMF
LFLIYENFRMEKEIDRVVGMRARVMKDYIRKVGSQTRALGLSITDYLTFYENTPINPDLI
KRFKNYPNLNRFGIPHISRENQGGSGPDAGTLTAVGSVHKLNPSLLKEIEAALNLRGQFE
SLTEKQSEVVWAYYLSERKFLYITPKFKDENYYFTDDLYAEPYWTQANPIANPAGRQIIT
DLYEDIAGKGLMISVSEPVYVKGKFMGVAAIDIGLDAMQRILESGDCIGRSMLIDENGKI
VAKPDNFALNDRLPFSVFSSILESKKSFFLQKGSFWIGVKIKEEEIWLVHEIQIFEYIIY
IIKNLLPFWVLTFTFFIVLVLYVKLRSSMNQVSKLIHTDPLTGIWNRRGFLKLTQRSIAL
ENRHKNEWAILMIDIDHFKQVNDRFGHDAGDKTLIRVAQILSRSIRQTDVVCRWGGEEFA
IFLCGVGQEISINIAEELRKEVENQIRLKDGNPVTLSIGVSGGKQNLEEAFTNADQALYQ
AKTSGRNRVCAFNFLQSSLK
>A0A5Y3V4E3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGIWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VFYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADRAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A180EZ60|diguanylate cyclase|EC 2.7.7.65|Bacteroidales bacterium Barb4|TrEMBL
MECIFMRIKKPHLRPIVITLSVGGILLTSIFLIAVIMVFQRENIEKDLLYANSSYAMKMS
DVMSGYIEMAQGELAYGAKKIKSTNDIDSLKDEADRLRLQSGMFNSVLVVSNDAVVLATS
PESLDLVGTRLNSSASKLAIEEKKPFISSPLKSVTGNLIILLSHPIYDKGGNYIGYVGGS
IYLKKHSLFGDVLSRHFFKNNTEISIVSDDGNVIFNNDKSAVDRPMVMSDDLKSKLTASD
RGEGAFFSSGHRYLLGYASMKNTVWNVLVYSRADSVTTILIAYAKSVLVLLIIIIIVFSL
ISYFIASSISLPLEKLAISTNAKDIGASLVYIKAINAWYAEADRLKKALFTYIKVMMERV
DSLNEVALKDPLTGVNNRLGFLSKIQNHKRDSGYSVIVIDVDFFKEINDSFGHGVGDEVL
VSLAHIINSCCRSEDVVCRFGGEEFVVFLPNTSVVTAKCVAERIRSVIESTVFPNNLRVT
ISAGVATQDDPLGRIDFLLKNADDALYQAKREGRNKVIVYSAI
>A0A0H3FYA7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56)|TrEMBL
MDKPLWPKKFHRLFNPGRVVNICFIVVLFFSTLLIWREIRVLEEAYVANQRNNLENVAHE
MDGLLQFNLNRLLFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTLTV
YGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNNNRIFSERMSYVSRSGFYTTT
DAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPLDY
EHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTPLSPKEQ
EQLRYALTNDNHGGIRQLTRYISWEKIRNFDGVLLHIHTLKEGVRGDFGTISIALTLMWL
MFTLMLIVSWGVIRRMVINMSVLQASLEWQAWHDALTRLLNRGALFERAIAAARSCRRNN
QPISVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREQDIAGRVGGEEFCIVLPN
TQLPQARAIAERIRLRIHSREILLHNSVSLRISASLGISSSETSDEFNFEELQSIADHRL
YLAKQNGRNRVCSAG
>A0A519JFL3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLNTLNAWLLESFSVGINKRYSEAVQKQHMVGHVHARVGIPSWLIMRGVCEIERK
IFELMAQNPQQDMFTVCSYMVQIMGFSTEIMCRSYEAKTAVNQEIKHSYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGNVGFHHPILSKSEFGLWFIHKASYAFSGSDQVQLIID
RIYQVDQLNTAVIQCTQKDEILGLIQQIRDLNREIQILVDQLFQVSEYIESGNDSLTQLL
NRRYLNTIISREITFSRQNGTSLSLLAIDADFFKSINDKFGHAAGDLALKFIAETLQKYS
QGSDYAFRVGGEEFLLLLVDHDAQRAMHIAESIRKYVENGMITTTQGLQFRFTVSIGCVL
YDGQPDYQKFLDAADTALYAAKNSGRNRVYLAKSELPASDIASVEHSQC
>A0A4Y1N0E0|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MVTKLHAPPTRFAGWLLLSAAIAVMAGAVAASLGNRQSLSLEREMERLRTESAEARQLTI
ALLDGESALRAYALFGLVQDQLRFGRAAELLESGEFRRIASLVDSAQEDTGSPPILGPIT
RIVAARKDILDRLQAGERETVIEEGRRGLLQAQGETVRLALERFVRLRVAQVEQAARGMQ
RVQARILVLVMLGAGLCLGALAIAWWQIARHGRAEQAVRREMDVRGAEIRSLLRMSDMLQ
ACQTEQDIRRVVLHTAQEVLPGVPGALYVFNNSRDRLDCTAVWPEGTKLASVNHFSPENC
WALKRGRPHRHGPGADIPCEHVALGLPGLEIPMTARGEVYGVMQFGAAVSGLPDAPEPQR
DLAVALADGVSMALANLSLREKLRNQALRDSLTGLYNRRFLEEVSERFAGQADRRGAPVA
VVMIDVDHFKQVNDRHGHATGDAVLRALAVLIQGDLRRGDVACRYGGEEIVLLMPDCDAE
NACRRMEEIREQVRALHQGTDTVLPRVTISAGVADMPAHGQTIAMVLKAADEALYTAKQS
GRDRVQMARLLKPEDGAEPPKGAPREAPREAPREAPRLEIARLR
>A0A2P7R391|diguanylate cyclase|EC 2.7.7.65|Zobellella taiwanensis|TrEMBL
MTDPLGYGQRQWLQILNDYDPALRRRVRELVLAHSERMADEFYQYMITQPEAREFLDHDQ
VNLRLKASMQHWLEQSFAIDDEAAIALTIERQLEVGRVHARINLPINLVSMGARLHKKRL
MALVFGLEEEPGYWQAACGYLQEVMDLSLELMSLAYVSKSERKSRAAEAYRLHTLGLNMP
VERERQRAALLDWSQELIFGLHRGDRPPGGIIRSEFGLWFQHKAASVFEGAPELGQIEQA
LQQIDLVILPELRAAGSDTERLARQMAALQQEVKAVGYFLATLFDRYIELEHGRDTLTRL
LDRRFLPAVLNREVRLAKRGGAAFSVILFDVDHFKQINDSHGHEGGDLVLQQIANLVAGA
VRSSDFTFRYGGEELLVVLVEAEPAKALEIAEKIREKVAANRLQLPEGKTMQATLSGGVA
GFDGHPDYEYLIGRADKALYRAKHQGRNRCLLAD
>A0A1V6A6S7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin153|TrEMBL
MVVPKDDNAREVLIQAEALGKISNKEAINKAKEAYSRALDEGDNLTRLKALVIMGRCAFM
LGRTSEAIKWLLECISTAETLGMPEQMAEAYNQLGNTYQVINDYGRSISCYLDALDIIRD
NRLFWLEGSILNNIGALYMSLEDFDRAADYFQQSYEKDKTVSDTSVILLLNLASIYAKKR
AFEKADKYMRSAREALTDKGELLMTAWCSLTEGEICQAKGDMSHAIGHYKEAISICNSTG
DIFNECDMGTKVGQLLMEAGNLDDALKVLTDTYGRCDELKSNDMKRKVALLIAKCYTAKG
KDNESLEFYKLHSVHVEQAENEHVENQRNSVLLQVQQHETNLERLRLKQLSEELLRTTEE
LKEAYATMERQAIIDSLTGIRNRRSMDAMLDVSWKACQDESKPFTLMLVDLDCFKNYNDY
YGHPAGDSDLRNVAQSLQMTLGDEKLVGRFGGDEFIAVLPNVPGDEARTLGNKMLENVRN
LRIPHERNEASSIQTITIGAISLVPGKDDSQGNVLHMADSALYEGKKQGKDRLVLYCRE
>W5SP57|diguanylate cyclase|EC 2.7.7.65|Borrelia anserina BA2|TrEMBL
MMEDMILDDFDGAVVEPHKLLLVDDTPTNLDLLVGILQYNYEIRIALNGIDALKQVEIFS
PDLILLDILLPDVSGYEVCKRLKSDPETRDIPIIFISSRDSIDAQLEGFNVGGVDYILKP
FNGRIINARIKTHLELKRLRDYFKNLARIDGLTQIPNRRFFTDKFAKFWMQALEHSRNVI
VGMLDIDYFKKYNDNYGHTNGDECLKLIAKSLNKIAVRYKIDIARYGGEEFILFSVGKSL
DEMIKIVDILIEDIRNLAIVHEYSSISNFVTVSVGLAEQIPHDSNFTNIIKRADDKLYEA
KIFGRNQLKY
>A0A6I5AK95|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MMRNTMEIDAILIELNKSIDAHYKWLVNMFRCAVTSNATQPDIMGDNAHFVCQFGQWLNN
QSLRNEDDCSYVNKINTVHEKMHLSGKDLLLAILEKRSYPWHFTKFEDALLAFTSAVMDY
KIYLLSIRSNIDILTGLPGRRMLDESFDQQLIDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDVVLRALAANFLVWTRYDEQAYRYGGEEFIIIIRTKTDEQARQAGLRLCQLVGQQKIPY
ADGEIAITVTGGITRAQRDEKLDTALGRADRAMYQGKQSGRNRCMFMDEREQITLVNASD
GLSFHLSA
>A0A127MXK9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MGATGQSRIRHDSRLWKLVWPFIAVVLLQGLLGVGSLYLISGVRAYVGGESLWSKGQKDA
IHYLQRYGETRDADDYRRYQEAIAIPLGDRLLRTALDSPQPDYELARKGILAGGNHPDDV
GAIITLYRYFHDFSYFNEAVRYWKEGDRYLDQLQAIAEEMHQRIQTGQVGPGDISYWDQR
IQAINEGVTPASMAFSAALAQGSRSVMRLLLAANVVSGLALILLAAWRTRNLLLAQRAFQ
SALDSEREKAQTTLAAIGDAVITIDENAHIAYLNPAAERMIGWDSEMAVGLPLKSLLRML
DETSEEEDLALVGQVLRGEVEAGSEISKLLQRLDGSGVVVTLVGTPIRVGGRIVGAALVL
HDMTRERQYMESLSWQATHDSLTGLSNRREFEYRLEQALERSAQRNDRHSLMYLDLDQFK
LVNDTCGHAAGDELLRQACSVLESCLREGDTLARLGGDEFGVLLENCPPEVAEQIAENLR
QGVENLHFVWDRRPFNITVSIGVVHVTAMLVSVEEALRCADMACYLAKEKGRNRAQVFSP
DDSELSMRFGEMAWVQRIRQALDEDRFRLFAQRIRAVDPQAEEGLHVELLLRVLDENGRL
VPPNDFIPAAERYGLMPLIDRWVANRAFEILAERREAGCEPIATCAINLSGATIGDASFI
QMLRELQPAYGLAPENICFEVTETSAIANLVSATQFIHELKAMGYRFSLDDFCAGMSSFV
YLKHLPVDYLKIDGSFIKDMLDDPIDRAMVQVINQIGHVMGKRTVAEFVESEEILEVLRE
IGIDYAQGYAVGRPLPFNRHYSGQAEPALVEPDTTSGR
>A0A259U9F8|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MLDIDNFKLVNDRYGHAVGDIVLQQVASTILGNIRENDMCGRYGGEEFLVVLNNTSRSLA
IEVANRIRSRIAEKIININIAENFSVSVSVSGGVSYLQGRDSIKDLIQRADQGLYLAKRS
GKNCIKTVDNA
>A0A7W5IGX2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. WP4_3_2|TrEMBL
MKPSTHPMAGKGRRFVERTWRLRMVGLALGFFCVASVFLQQQRGAVLWSLLVFHGFIWPH
VARRAAHACVVPYRGERFNLMIDAAMGGFWVVAMRFNLLPCVLILVMLSMDNIAAGGLRL
FLRGVAAHLLGLAIGWLTLGFVVEPETRMATIVACLPFLIVYPIALGWSTYRISRKLAEQ
TRTLEGLSRTDGLTGLLNRRQWEILLADEFERCRATRYASSLLLFDLDHFKVVNDTRGHQ
AGDAVLCAFAMLLREHFRVSDCIGRYGGEEFGIVLPGATLAEARSVAERFVATVREKNKE
AGGQCPCTVSVGVAQCDESMMDHAAWLKLADASLYRAKMTGRDRVVTA
>A0A5K1JE92|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSIIAYLQRLANGVSTAELDVAALPAGLRAVGEQLQKTHAILQQERQLLER
NAYIDPLTNLGNRNGFDRHVEQLWRKGDPFTCAYIDIDHLKHCNDRFGHAEGNRYILSIC
RTLSETMEHDEMLFRIGGDEFVLISLSANEIELEQRLEQVRTRLIEASSGGKAPMIGSFS
FGCSRVDPLAGDTRRQMTMDADRKMYRYKLMHRVQQPKDDDAPQRPIVDQLPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSLDMWLARVHPEDRDNVRVEL
DMVINGTWHFHYMQYRVMDATGKYVLCDCTGYRLDGTDTEPGMYVGIIINRSLADTTDSV
TGLGDIHALVNAIGEMRRVARKAGLIAIKIDDIAQVNARFGFDAGDRVLAECAACLVECS
RGKGRMFRSTGPMFVALFDDFDPEETDAIAEEIERFLGSPVLFGPFEYQPPIRVATLHLD
GVDRQPVSILNELKALLGKAVQVPGTKLD
>E0J6D1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / LMG 11080 / NBRC 13500 / NCIMB 8666 / NRRL B-766 / W)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0H3EZP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / LMG 11080 / NBRC 13500 / NCIMB 8666 / NRRL B-766 / W)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A1C6B3N5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTIFCHVIIILEMVTINFYTLNFCSTPKLRPVALWASFALFTAALVGGMICLLSPLPSYG
NGNGLFVLFGFIYLLPCYFIYDQPLKYTFTVMCSAWIYTMLAFSLAVRVATFLPQTDFSL
TILIIQTVFYALTLRLFLRFIKRQFLYILQNVTDKTLGSLLRLSFFWFISCVLLNYVFVT
KDQALLELILVVIIGAIILRSYRVFHDLVCADKDAEQLRRQNRTDPLTGLKNRISFYEDA
QALIDQGQPFSLIFIDLDRFKTINDRYGHSAGDRYLAGFARAARRVSAGMGETYRISGDE
FILLCSLEQTERLRGRLERSPISLGKGEPEFLGFSFGIASYPENGQHLDGLIVLADRKMY
VHKSRLSQVKGC
>N9QGA3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 101966|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1C5S9B6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSNITQNFSVWGGIYGSILVGFTILYMLTIVFLEKKEKKRYIGLSTTDPLTGLMNRRAFQ
RTLEDELRNQKPGIFIFIDVDNFKNYNDRYGHNVGDLCLTHFAQTMKKIFPDGSILGRYG
GDEFVVYLKNTSSESAQQYMQYFQGQVAHMHLPSGEAIELSASAGGAAFPKQGEDFISLC
RSADMALYDVKRNGKAAFKMKGH
>A0A1C5T3K4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MQKRKIWENFLQWVLPCVLLVIALVLSIYDFNNKMEIAIQTVVDDQAEQIGLYYAAGVED
KLKALGNITDAVASIMAARLDRGEAFVNEKLDTLMKASDAYMVVYCATNGTGFLNDRRQI
DMTELNYYDSILGETPHYLFTRSDGINGQMAFIYVCPITNSGNVNGYLLSYMEPAEMSDF
FENSVYGDKAFFSLVDRNGTIMACYGATQGTKILQNDFWNSLKGVAESLGSWTLFDRQQQ
KGDNGILHVNENGVGKILCHFPIADTAWNLVVGIDESYLSGIQQSFRGPIVDLIVKISIS
IAAALIVITVINVLVRIKVSEHSKVLEDKADTDLLTDLNNKMATERKIREYMEQYPDKQG
VLFVLDVDNFKKINDTMGHAFGDEVLRNLAVRLQSMFRATDIVGRTGGDEFMVFLKDIRD
ITMIEREGKKIEQFFHQFEVGEYVKYSVTASVGAAVFPGDGNTFENLYKSADNALYVSKR
RGKNQLTFYKKPEKETQ
>A0A1C5Y651|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDDLEQYKDRLRIALSSAKICIFEVDLLRQLYTFFENAEDIFGVSGDSILKDVQSYSTLA
PEAYRLAVSKYFSHPDDSAVIEAAFAQILRGEPATYEARMKAGGSAFIWCRISVTPIIED
GKPVRMVGVITDITDLKEKTESLRRAVNLDSFTGLYNKDHTIALINNILDMGTHVKHALV
ILDIDNFKKFNDTYGHDQGDKIIKALSQKLKNTFRKTDIVGRFGGDEFIVFIQNIEDDQW
LRDKLHHLIRFEAGTFTCTSSMGVSVFPLDAANFEMLFKKADIALYHAKSAKERAVFFSD
LDRNEKKDSLR
>A0A1C5WLZ8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKRLLSNRVRNAILMAILLQSIIFGIGLVITGTFSGTANRPYKVMESQVAEKNSLLSSY
MNNVLLLANTMEKELAKMTDEVEIQNRLVDNLNHASSSDGIFYIDLDGREALVLHDGEPD
IYSSTYGDISCTIGRTQSSYPIALSKDWRPKLTDQEWGMVEQFWENKGNGGTWFFTSERL
YYVLSQESGRGRRIMGLEISSDMLDSCLKLDNPPYQGMTMLLLSDESVRFSLDQTFEGTG
YDLEEKTGYISLTNNGVGYDGVRSALQTYGYMYGGAVYVAAVCHHSELTALSQSTILMVA
GVYLLSIFIAIIFSYIAIYMVLKPIQRLQEDIACQKPEEVHFRESGIVEIDRIHQALNDM
ADKLEQSYSRYSFTMESAGDNVGSFEYQEKGGRVKVSPSVRILLGIPADSREPVNEIDYD
KWSRILGSLEQIEELEDGYAFTDIYGDRRAVTIRQRREEHGVFGLVIDKTDAYNEIVRLR
NISQHDQLTGLYNSSYLKKEGQKILDENANRVNALVFCDLDNLKYINDNFGHEMGDRYLK
AMADLLTSMTQGEQCIAVRLSGDEFVLFFYGYDNRDVIEQKVRDGYAGRPSLRLPDGTDH
RINASIGLAYAQRETESMDGLLNRADRAMYRVKHGEKNGIAIYDKSDEAGPA
>A0A245ZDG3|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MAEFLTQQEAELYRAIGRFLCEQKLSVDPANYAFAFRVVSDPAGALARSVAALTDGGVRL
TSQDIAALGGTPTAGTAALVSLHDGMPTAAPRPSQSNGKNEAEAIVARAEMQVADFSRAV
RSIHAETSGFGRELAASAAAMRDSRATTDFDEVFRLTAAMIDRANVAEHRMAAAEQEAEA
LRSALDKANGTARLDPLTELANRRAFDEAYAALSPGTPVALAVCDIDHFKRVNDDFGHAV
GDRVLRAVGSSIAGECGNAMVARYGGEEFALMFVGVDLDAAVAMVDRARSAVAARRFRSR
ATDAPIGAITISAGVSAGTSDEPREAVFARADAAMYRAKASGRNRALAAA
>A0A0H3HDM1|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 / BUCSAV 143 / CCM 1901)|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSMSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A446CRE2|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MSSSSPGIPSSAGRSDDASGRACYLSASNEQAWEAVYRSVDAYTRGQVAAVVADSVSQLV
DTFYSVLLADAEAGPRLSHEIVATRLHSGMTRWLKGLLCVREQGDVATLMATQKKVGEVH
ARVHIPMHLVMAGARILKNEIALRLRASDLDGAAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQALPRLAASEFG
LWLQHKGAAMFESAPALQQITEAVARLDEEVLPRLLRGETQGQVSSIPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRTEFSVLLLDIDHFK
AINDRHGHSGGDQVLRQFAQVLHQSCRSSDFVFRYGGEEFLVLLVDAGREAALAAAQKLG
AEIRRQVFTLTEAGPLHITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSEAA
>A0A3P6L016|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQHETKMENQSWLKKIARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQCNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2X2IA47|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LAFLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNT
>A0A530MB01|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp|TrEMBL
MDKDFTSTSRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVTNAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGAMIGEIHLTARDSLISHFIWMSFAVLTGCILFATVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMTEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTIS
>A0A1M6ALR6|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MNVIRYFRPSQIPALYTLSVAGIIFISALIGSLSRPDEMSMTIFWPANAILIALMFRYPQ
RSAFPVWVAAVGGYLLSNYVMGEPPQVNVMMTMANLSGVIAAWWLYTRVFSFGVYLKSRY
SVLHLFILCIISSVVSAIFGAIVMEFVLDKPFFLAMIYWFSGDLSSMVAFLPVALAFPEK
LVKINRKLRLYDFLPLIMVVFSVAMIFVLGGPGAIAFPVLALIWCALTYSYFVNTVIVMF
FVICLFACEVLGLLPLFSADEFVGDTISFRLGVTILVLAPLVVASMNDARSRLIRKLDHA
VNYDHLTNVLSRKAFEQRGEQLLSSPHPDQNHLAFLMMDLDYFKRVNDQFGHQGGDELLV
HFAKLVQDIIPPDCLCGRMGGEEFAAFIPGSSCERASSIAERIRHEVSHLELNREGENTI
STTVSIGVACVNHGSAKWEELMEMADKALYQAKHQGRNQVRYFNC
>A0A240C232|diguanylate cyclase|EC 2.7.7.65|Serratia ficaria|TrEMBL
MRTTPLPDTSKFWQAFIVFLLVFAACMLGILSRPTGFLAVFWPANAVLLAVLARNPKLAN
RYGWGMAALGYLAADLLTGSPFGRAALLNGANLAGVVLGYLLFMRLQPPTRMLQRGSSSM
YLFGICLVSAAVTGLAGAGVSRLLFDRPYFTALALWFSSEFTNYVTLMPFILAFPADWQT
CLRSLARRRCQWRDLGRKLAVLALLLLACVCSLLVGGPGAVIFPMPVLLWLAMSFSLFST
MIAVLGYVLWCHLAIDLGLISTNLDMNVLQNTVSMRLGVALLALGPIAVASMNFARNTLL
STLEHVANHDALTHVLTRNAFMQRGARLVAQKGELICVMMLDIDYFKSINDRFGHAGGDA
ALMAFTQAIAGNLRDGDLFGRMGGEEFAIVAALGQQQQAMQLAERLRRQTEAQAIVMPAG
NPLQITVSIGMVTCLGGAGQNLDGLLKMADLAVYKAKNAGRNQVATPESFPLIYSDI
>A0A0M6ZXK4|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MLRRHIAPHSFALQHVENRVSLTDTSFAPVIIISIGCKIIRRFNLKNLQARTWALRWRNP
ALCRAFLNRAMDARTVPALEGRPLAFNLSWLERWRGNFKTAGELAEVAFQSMSKQSDPEG
WAELLVVKAVCAYSLGDHKLADEFLKDGFETLGPHAESGAGIEVLTILATLRQYSENYDE
ALTHLRDALQIAEDTGLYFEPGRVLHNLCRVNCLAGNIDAALDAGQQSVEQNRSRRNAIM
LPYAEEVYAGALVASGNYELAREEAEKGLRAAVFSDDPRVTCQLHFAIGSSYLKERRPAD
ALKVFEQGLKEATAFDYHLWIRNFHLHLSQTHEAIGTYQQALSHLKVYAEMQATQFKVEA
HRQSYELRSQLEYQLARRSAEYERELRDQSVRLNTELVQANETLQMLNRRIEHNALHDAL
TGIGNRRMMTQYFGRAEQSDESSDEIAALLIDLDGFKSINDRFGHATGDEVIKVISERLR
TLLLDQELLVRMGGDEFLVASTVRTEQGELAKLAQDILDRINQPIDLPGDQGAVGASIGI
SVTRIRPNLERSLLQAADEAMYAAKRSGRNRAFMEPAPAKTGS
>A0A5E6RH33|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRQGKGLSFARRIYKPRIIGTAMCCISVIAALYPLAMPGWVWALLLVNAFAWPHLAYQ
LATRSKFPYDAEQRNLMYDALFSGFWAATLQFTPLTTVTLLSMVAMNNVAAGGKRLLIRG
AGAQLLGAGAGALLFGVQFNPSVSLVQVYACLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRIDSLTGLLNHGSWKDLLHLKFHKCQQQQSHATIALIDIDHFKQINDTHGHIVGDA
VLRQLSLELRRSLRENDLAGRYGGDEFCVILPKMPLEKAAEVMERIRETFSNYRNPQIPE
LRVSLSIGLAGFQPSFTDAAMWLNAADRALYTAKDTGRNRVNVSDERVAYSA
>A0A379ICS2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPFCRGTMDQANQMDGHGREQDQDFFIEEQVRTDRLHQLFRQSFSAVLGSYLAAGMLCWL
CWDRLDPRLMIGWLVLLAGSSLLRLSMFLRYFRSPRSERTPQRWERHYWLTLVLSAGIWG
MGAFAVMPTDDRLTQALVMLFAVGMSVSAVSCYSAYRSMTLVSMALVLLPCTLWLLVQPS
KMQMGMAIAVLVFSSFVVGASRKLSEALETAFRLTREIERAHSISTRAAQTDELTGLMNR
RAFFDKAQVLYDQCKRTHQPLCALMLDMDHFKAINDTYGHQAGDRVLRQIGQVISASFRQ
ADIYGRLGGEEFAVLLPDTTLEVARDIGEQLIRAIAGLTIDPVHGLSASLGVASTHAVGD
DLQHLMNTADKALYRAKAMGRNQVAVAS
>A0A1V4WYC3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin047|TrEMBL
MKNRARNLLTDRSYRKLLDSLYEGVYLVDSERTIVYWNDAAEQMTGYKSGEVVGKHCWDG
LLMHVDSRGTSLCTNRCLLHEAMELKKSVEGKVFFHHRDGHEVPVTVRTTPILGDRGRVL
GAAQIFSDNSSTEDLGRKVRELERMALLDPLTKLGNRRYGQMNLSGKLREFKRYGWPFGV
LFIDIDKFKAVNDTYGHDAGDRVLRLVAATIRNGLRSSDVVVRWGGEEFVAIVASVDEEK
LRHVGEKLRVLVERSSISLEKETKSITISIGATLARKRDSSASLIKRADTLMYQSKKEGR
NRLSI
>A0A174EJQ2|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MERFRQRYGIALTKKKLQEIILMLMAWEAVFAFSYLGYIELPAISTTTLHILVIVAAMML
GAQGSVPVVCVFVVTSMWIGTYSLSQLDRVFSPFASGMPLGSIMLVFARVLFAAGAGWLF
DLYFRKPRRYVYLGIAGIAAASTLLHGLCVFAALYCSFPMLRQMILENLFSYPIFRDWLS
YVLAIIACCGIHWVLTRKSVKNRLSQLCDCPPAMQESGNRKQLIYSETVAVVVGILCILF
LRKAIFKELYLQGIDVSENLHQNITAFLLQTLVALLALFSVVSVLIQWIYEYYTAQRIRM
NKKLMEQRMKSSVDVLTGVFSRLAYHECLEQYADSVPTDLTVFLMDINGLKGVNDALGHE
AGDELICGAAQCISPRRWGIGGKSSASVGMSSWCWVK
>A0A1C5MIJ1|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MMNDTAKRRRIKIGLLVSHLEDDFDDAVAEGAMIGAEQCDADLVIFPGRYIDGIYADKLR
TVYEYQYNTLFDMAAANKFDVLLVLIGTLGTYLDNEHKVQFLKKFAGTPVITITAHIDGY
PCIMLDNRTGMKEAIEHLIKVHGCKKIGMVSGPKTSDDALERLDVYKETLEENGIIYDEK
RVAYGNFSKFCVDEVGKLIDDNPELEAIVFANDQMAIAGYKAMEERGIRPGKDILVTGFD
DDPVAEELNPHLTTVKADPSELGYHAVQEAVNYVINKAINNDKISSEMVRRNSCGCQGNS
KLKTISFGRISDDPEAFARRMSQFLFNKYSASETTAKMREVYVKIIYALDDYAREENLDN
EIKKDKVLEMVSTLASEEFFRFVNVDELYASVEYIQQKLISRFDNVEKHLKLNQTFIQIY
KILAERNANYCKEKLEDNEFLAWQANSITRDMLVFEAYDDRAYETVVDKLMRLHMESSFL
FSFEPAIIHFGTDKWQPPEYMYLKAYHNGSDAIQLPHEEQAVKYTELLSNKYLPTDRRYT
LVVSPLFSNEEHYGILMCEIKHEYFNYLQSVTVQLCAALKIITLMKQQAVTQKQLKKSLI
EIKENNELLRDLSRQDALTGCYNRRGFFEELRKRLSNDKNEGEKAIMVFADLDCLKTIND
KFGHEEGDFAILSAAKILKHSFGNSEIVGRIGGDEFVVCAFLDNAIDIPSMRNHIEAVTR
EYNIKYAADKPYIIHTSVGVYPFVCSATLEIGELLSHADILLYEEKKHKRSILKSDYE
>A0A1V6C9C8|diguanylate cyclase|EC 2.7.7.65|candidate division TA06 bacterium ADurb.Bin131|TrEMBL
MKIAWIENNGIRFWDIVKKFLFIFCLTIIIIVGVTAILYFASAKNELSMVENQELTNIST
ISKIVARSFDTTVADIVFLGELVSDYVSGKKTETEFLNTLSPFLRSKSYYNKLVICDTKG
KIISEILIKNGEILKKYDTKANYKKNPDFINTLAEARGHVYVSDFRIDDGAPVLIFGNPV
FGQTGKKNAVLLVFYNCKPIFEIFGKTFEQERTDKEKLTRYFIINSNGYWIKGPNPEDEF
GFLFESRSEKKFLHIYPEAWEKIKSDQTGQFLVKSGLFTFTTFYPVARAEKISEQSSQKF
DPTISGNVHSFDYFWKIISFVPRDLCTIQSNNRLKEFLLYDSILVLFFIIVSWIIARTSV
KKEYMEKLLEHLSVTDPMTGLYNRRGFFLLAQQQLRIAERINQSIVLFFFDLDDFKSVND
KFGHQEGDVALTKTAEMLRKTFRQSDILGRTGGDEFIALVIQNNPIDVESISTRLEENLK
NLNSEINKEYRLSLSFGVAYFDPAKKQTIDNLIATADKMMYAQKRKKKKLRQQEDLDSQQ
DVAH
>A0A5P9JRL5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MTRFLCIALFALSGTVSASVDVTLDLSAVERDWLADNRSVSICVDPDWLPFETLNARGEH
EGIAADLLRLVAQRAGLQLDIVATSDWGQSVAFSQAGRCQLLSFLNQTPARDAWLIFTQP
LFTDANVVIAREDHPYVADLSALEDVTVALPVGTFVEESVRRDFPQLRVIVTDTDAEALA
LVNERKADLTIRSLTVAAYTMRREGWFNLKIAGQLASLDNQFRIGVLKSEPLLRGILDKA
ITTITPWELNQIANRHAPIRIESGTDYRLVVQIVVVFSVMLLTSLYWIGRLRRLNEQLQI
KSQTDALTGLANRAELDRRFARALEQARRYNRPLSIVMLDIDHFKSINDEFGHQTGDRVL
KEFADLLVSGLRGSDAVGRWGGEEFLLLCPETNGQQALAFAERLCEQSRASMFSTGRGQT
LSAGVAELGPVDTADSLLRRADAALYRAKHDGRDRVCWLASDE
>G2FDM9|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Tevnia jerichonana|TrEMBL
MDSEHFAIHAALALTRQSDGHALSSQVIQILQGLPYVTNATVYEVFTKQRIKGPDADLSG
AVVRKFCNGLSRDALSIGSESGLTQCLLDNSPVEVKQQEAQGVRLVFPVKSGINPARLVA
VEGESFSPRQRVDLLQIIELYTNQTQIIDAKERDKLTGLMNRETFENHLMKIAQMQTEVG
SNCAWLAVLDIDHFKRINDTYGHLYGDEVLLQFAQLMERTFRYTDILFRFGGEEFIVLMT
ETTGEVGARAAAERFRETIASYNFPAVGQVTVSIGFTAVSSKLLPTDLIDQADRALYHAK
ENGRNRVVSYSEISQVDGDDHDITKQELF
>A0A8H9EBV7|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLSLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAH
PGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A1V5E2B2|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaU1.Bin208|TrEMBL
MITAKAANDGINIRGKSATNIEVGCGMACGKDSYSVGREAASQAISGITASSLSAGIVFA
PVSYQLDEMLSGIRTVVGDAPLFGASSAGEICDGTSSGSVVVMVLASPFLTVSVGLGQGV
SEDWRKAVQETVGQEKLSPFFSPQSDAIYNGLTKEGRSAFAILLTPASTRNTDSHSPEIL
EELKGLSRGRIPFFGGTACDDRQTKGESNYVFHGDQAYRDSMVLAVFETSLKFGIAMGHG
FLPTVNKATATKVRDREVLELDGKPAADVFAALHDLPRESLEGKPLFEQLLVKPFGMRNT
LGQYTLFVPRRLTPQGGVLLAHPVPEGSQLFLMESFDDEIVAAGKDTLFRAMSQSGIARP
AAILVCSCFLRMYLLEGRIDREISAITEIMPGVPLAGFYSAGEQGINDDHVSRHNNESIV
ILILGQELSYAAQVANESRILHRILESRIIEQQRLETELAEQVDFLQALIDNIPNPVFYK
DPDGKYLGCNKAFEKYLDVRREEILGKDVQEIPTADFIDLHHRMDAELIQNGGSVVYESM
NRPADGVAHHDIVHKALFHKTDGSLGGFVASVTDISDLKRAKEALAESEAMYRNLFENAS
IGMFQSTLEGKFLRINKVYAAMLGYDSTEEVIEAITDTATQIHADPRNRADMLAAMEERD
WFYAEQPYLRKDGSIMIGKLAIRRVLRLDGTVAYLEGIVEDITERKRSEEALINRERELR
IKAQNLMEVNTTMKVLLDTMERDQEELKERFLTNIQNQVLPYLGKLKKSPLQEDQKGYVE
MAEAHLLEIASPFTQKLTSSFLNLTKKEIQIAYLVKEGKSSKEIAELLNAKQRVVEFHRE
NIRSKLGLKNKKGRLAMLLRSFS
>A0A653U7V2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 8AS|TrEMBL
MSEADFDTTLATDFARALHDVDGERWFRQMADGLPLIVWTARADGVVDYFNRRWWDYIGS
RPATPSETGWQEMLHPDDLQPTLARWRQALASGEAYAMEYRFLRPADQTYRWHLGRAEPL
RGAGGQIVKWLGTCTDIDDQKRAAEALVQIQEHLQEQVHERTQLIERVNTHLLAEVQKGE
YLLRQLQSHSDNLARIIATQTRLAQAELDLDPFLELMVQQMQALTPASGVVVELVEGEEM
VYRAACGSVAPFVGLRLALGNSLSGLCVRSASVLMSPDTEDDPRVDRDACRRIGVASMVV
APLLLAGKAVGVLKIMAQQANAFSASDVQTLQLMAGLLGSELGHQVDFENNQRLLAERTE
EVAKRMASEAVLRANMERTQRIIESSHEAFVCIDPQGVVCDWNSEASRIFGWTRGEVIGR
PLTSLIIPERLRDAHHQGMARFLESGQGPVINQRVELPALRKDGSELIVEITISTSGSGA
QREFSAFMRDVTERKRTEQEVLLNQQLLRSVTDAIPAVVAFIDTREVLRYCNKPFLQTFG
KIEAQCLGHTLLELLGAQEYGFIQPHVQRALAGQQTSFERALKVQDNERYLEARYVPERD
VGGEVRGFYLILWDITERWALEQQFRLRALRDSLTGLLNRPALMEALEHAFAEHGPGSLG
LALLYLDIDHFKEINDSLGHAVGDEVLQVFAARLERHVRASDAVARLGGDEFVILLQHLP
SVGHACEVAAKIIDAMAEPLHIRQHQLQVSTSIGVAMLDGQTPCVQSLLEKADQALYQAK
QAGRSCFVLAP
>A0A7G2JN88|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MTYVASIPTLYSDACITYATLSISYFALSKNAPFSYHSELWKRLLFGALAGLAVLFLNQD
RLELVGDVHYSFVMIPMILVTFYGGAVSGFACYLMSLIFSGGFTVDNLFIGSIIIPLLLS
RVWRRKSNRVFYLTICLIALYRIAVVWFFVDMRVLWPDVLLYQAISALCLAICYHAINFK
ERHIHAYFSMRDKATIDSLTHLSNRASVDYRLMLQQVERRPCGLMILDLDDFKHINDTYG
HLVGDVLLARVGTLLKSSVRSEDFVGRYGGEEFIVITANYDPATIDGVAERIRRSVEATT
FLLDDGGEAHITVSIGASLYLPGMAVDKAIEVTDEALYDAKRKGKNQVVCSRLMQFSPLG
AGFRRE
>A0A564IM93|diguanylate cyclase|EC 2.7.7.65|Klebsiella spallanzanii|TrEMBL
MKDESQKYISIIFKEWLLLYDSLTPEVKSVLKNIAEQQAEALATRFYDFIFQDPDIARHL
TYDLVQERLSSSLAGWVRDILMSEKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSEIDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKTDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDTLLSAWKSSADDSEYKNTQSLLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGAETEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKVHEGDGN
>I6EG76|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKMAAADGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>I6EJU5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQ
AMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTM
LLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSV
IQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTE
AAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEEAGDYDFEQLQSLADRRLYLAKQ
AGRNRVCASDNA
>A0A6S5XU28|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTYVVKRSLQQWLHQRSNPGLIVNLCFIIVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVANGLDRQLQYNVDKLLFFRHSMRDALQTPLAFGVLHNAVTRFNTLRNTTNWQIAVDE
NRTLPINGVSDAFVEKTTLLNRDNERLANELSAALEVGYLLRLASSHSSNVERVLYVSRA
GFFIATDTPAQPRDISPRYYQLVTQPWFSQQSERENRARAVRWFISPPSSFIGNKRLITA
SVPIYYDHFWYGVVAMDISVDTMKQLLVEALDNHTEGEYQLYDMRLNMIATSESPESTVN
HFDASELAQIAHAIESDTEGGIRLGSRFISWERLDHFEGVVLRVHTLHEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYMLQHSLQWQAWHDPLTRLNNRGALFERANALA
KQCQQQSLPFSVIQIDLDHFKGINDRFGHQAGDKVLSHAGGLIASALRANDVGGRVGGEE
FCVVLPVLTLEEAANVAERIRARLDSKEILVKKSVTLRISASLGVSSAQETGNYNFEQLQ
SIADARLYEAKQGGRNCVVWRDHNKK
>A0A517TF14|diguanylate cyclase|EC 2.7.7.65|Calycomorphotria hydatis|TrEMBL
MVELKKIWSSSQLPTLPTVAIQLLDLSKDPETEIRQVADVIKTDPAICAKILKATNSSYF
GFQAPVTSIDRAVPLLGTTVVTSLALSFSLVEDAMTTGPVARHYRDYWMQSIVQAATAEL
LSEHTPGAIGCEFFLCGLLSDLGRLAMLKTVPEESCQAIESASERQCDLHHTETEIIGIN
HVEVGVKLMQNWNLPPSIVRAAQFQHDPPELIMEHASADDYNLIRAIATAASFGDYFCGA
NKGQALTRLRMLTTNLYGFDDQKLDDFVARAKEKTAEVGELFSVNTDDIGEPEELMALAN
EHLATLTLRQQMEATQAVARQQMLEEQTRQLESKNEELQKQVMHDPLTKVYNRSFFDEAI
AREVDRCGREAATIGLLFLDIDKFKTLNDNYGHQFGDQVLQQAVQHLSKVIRKSDVLARY
GGEEFVVLVSQPTERGIAKVAERLRAAVEQTEFMFEGSRVPVTVSIGAAMVLPARNDKEL
VTRLVAEADEAMYDSKENGRNQVHVRVLLSDAEKSLLHKVTARRFSRWLVNQQVLDIPRI
SQALLKVDAKHIRIGVLAQQRKILSAEQVEQIREEQSLSNERFGQIGIRLGLLNEDQLAD
LLAIQSEDPQKLAIALVSEGLLSREHATQYLRKYLLEAPRSTPAAPVGV
>I6F1E2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEV
PDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLTA
QYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFI
DLDNFKLINDRFGHNSGELFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISS
LRERIQQQIRGEYHLGDVDLYYPGASL
>A0A7Z1AFG8|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MSKDQHAPTLVWVVLVTIIFFLVLALVSGIVLRNEHHQHVQFTEELAKGQMEIIASIAEA
ELQKGNYESLSKIINQWAAKYSEVDEIKLVSRNGFIIAGYGPVQSSVRRYILEQDIPYSY
RGLAKLTLAISLEGAYKHTLKQGLRVSVAVFSLTGLFALLIYLFLTRRHKANLLSLMVEE
LKDTESRNIQLAAYPRENPNPIIAFDLNGKLTFKNPALRKLLVRRNITDPISILPDSHKM
FIDRLANGEREIYGEKEIDEIHMLAHYQMIDVADEVYVYIQDITAQRKAEKELRKERNQA
HITLASIGDSVITVNMDGLISYLNNKAMKLFNTDAGHAIGRHFSDMVRLVDDGEEWDIDS
LLAECRTSKPNQIVNEQVSLLTEEKEALQVQVTAARIFSQDIETDGVVIVLRDITREYRL
QEELHRQANHDSLTDLMNRSAFETHLESALDSARHRGREHILCFMDLDQFKVVNDTCGHV
AGDELLRQLGRLMRKHFRGSDVLARVGGDEFSAILIDCPLVQAIERIDSLREDVQQHHFY
WDNQTFRISLSIGISPINMYSENIAKLMSAADAACYSAKDSGRNRIIVYEKDSVTTKRRL
GEMQWVSRINSAMDEGRLVLYAQPIVKFDSDEQLVVAVEVLIRMRAVDGELIPPGAFLPA
AERYDLIERVDHWVIEEVMRLLADCSSNCPDCFINLSGGTLSHNRITPLVRKLLQKYGIR
PEKITFEVTETAAIQNLSSALRVIRELRELGCRFALDDFGSGLSSFGYLKNLPIDFLKID
GMFIKDMNTDSLDRGMVEAIKTVADTMRLTTIAEFVENDAIIEELCRVGIDLGQGYGIAN
PKPFDDFISETDDSNVIWLSAKT
>A0A1S7R7G7|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. CFBP 5621|TrEMBL
MPPRTLSAFIRIYLKKNARMSETIDTNIFNLAPVAMWIEDFSDVKSQFDIWRSQGVEDIR
TFLLEDLSRVAACSQKIRVIKVNVRTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSE
LWAGKTEFTSNAVNYSIGGKRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKERL
NRRYAEGMFKHSPVSLWVEDFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVI
DVNRATLDLFCAPDRQVLLQRLGDIFRGEMEKPFREQLMELWNGNLNHHREVVNYALDGS
ERHVLLHFSVFPGHEHDWSLVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEL
NRLERSALRPVSAIVIDLNGLKDANDKLGHDAGDALLRRMGEVLNGVVTAPNHAARIGGD
EFAILLPGADKQVAAAMVETVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRAD
MNMYEQKNAYYAALRNRSADNSDTTKNGPPEATSLKRLF
>A0A377M2N7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MILNGLTTSTGHEAGDQFLIEVGKRLLDEKTEDEIIGRLGGDEFLVACLSKAENSG
>A0A377LNY5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MKTTISLAFALYFARNDTLNEMLNVNPSQGLQMLMHLQNLMPTVSSISLTDTQGRYLRAP
EVLPTEKSKTFDPRTRPWFIAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPEGRLKG
TIAFHLDLTSMGFTLRQMVAPVQGEFFVVERDGAVVLHPDPGALFKQYVSEALMDKMTSS
EGHLYDKKTKAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAIIIILFG
LYLRHESRTVLMTIINAIKTGDVNQAPRLEAMLSHTIQSNKAREMAYVRQATHDALTGCK
NRRAFDSDVDELLSAHQPFALALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQIMQPHN
VSVYRYGGEEFAVIFQADQIASAFSLLDAWRTAVEKRLWREENLRVTFSAGLGEWHFEPL
EELVGSVDNALYSAKQQGKNRIIRTSVG
>A0A0X8VDB3|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MHWYKKFRHIFLIAIIFFVVTSFQTFEYLSYSKSIMQEQRKIAFREDAEVMGYRFQQRME
QQLIMLEALADYVVKEDDFSKENIIHFREYNTLLSDFKQIAIADIETGEAAYLDGIIVDI
SQKRFFQEALGKSRSIQFFQEEGRGDEEIILTTPLYSGNILKALLIAHVNYESVEKYILS
DSYGGEGFLCVTDKQGNIMGWHPGNRHFDGQNNILAFFNANNISLEKTLDNGAEKENLFI
YSSEGKVWYSSYTPLEINGWYLFSTLPEYLVTQNDDLFEELKIDLIVKMLFINIAACILI
YFLIRNEKAAVEKENNCLRTAEEVAGMISFEGDYRKDTFVVNNNYFKQFGRNPVMHKISD
FAKPHPFIFEEDREVFMKLGQELIDGKVTGNAQYRLLGKDGNIQWHQFVYRVWHDRHGIP
LKCYGMIVPIDQQMKVISKLQMQVEKDPLTGVLNRMAFEIYANLSLNGESGSQNHALLLL
DLDDFKQINDGYGHVLGDHVLVATAELLKACVRNSDYVGRLGGDEFAVFLKNVNKEQAAK
KAAEICEALEKEEMKSDEAIVTCSIGIACFPQNGADFNELYLRGDQALYRVKGKGKNSFM
LAD
>A0A447T8J5|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPIVSLHTPSILDFKATLISNAGYSLVLTAVLLLTWFSGRRERALLTLGIAGLLSDLGFL
INVLPLGLSGWQQLQLTNYLLLAFCPLAVICTRQLHGLPSGWRGCFALWLLQLLAYRYWA
GPDDFAARVQVVAGFSMLFWVLSVWAFWRFRHAYRGIGHWIAGLFALLQALVSLARVWYG
WHVGGRYDQDGILFNALASQALFWLGYSFSLCVLLISYEQLLLQVRQQAQQDGLTQLYNH
RTFHEQAAAMFARAQRAGDALALLLIDLDHFKEVNDRYGHQAGDEVLRQLADCLRAESRQ
GDLLGGTAERSSW
>A0A1Y0HIZ4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MALTMDKRGTLFTLKDDRWSKIKNSILTRIILFAFMIIIIGGFTRYYLSFQTIHTNLFKV
LSIHLEALADEGAQDVIHNLDVRKRFLTKLASLLPPSLLEDPKALKKWLIEREELNPVFS
GALFVLNKEGTLIAGNGTEMIEAEKAYAEDGFFKQAMTQAFVIGTPIVSTISTVPVLPLS
VPIKDDLGNIRAVLVGMTNFDTPGFFDRVLNGHIGQTGGFLLVDAKKQIFVAASQKELIL
KPTPKRGANLLHDKAISGFRGSGITINAHGIEELSAVASVPDTDWFVVSRIQTKEAFAME
ENIKTTLIRAHAASLIIVPSILFAFLFFFFRPLRTSASLADKMSLGEVPLKPLPIKRMDE
LGYLTAAFNRLMAMLLESQKELKEIAHYDYLTKLPNRFLMVDRLAQALARCARNDTRLAL
LFMDLDGFKAINDSLGHNAGDEALIEVAKRFSSLIRASDTLARIGGDEFVILLSDLDGDL
SCATSAASLVVSKCTEALKEPFILKGNRRYLGVSIGVAIGNKESLLDDLMVEADTKMYKT
KNRTIPHINAIPSSVNIPLR
>A0A1Y0HLK8|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MNKQLQELTDLTIKEILNLEIVLPEIYRDIFYTKAKELGIKVSDIDKEVALIYALQKIQY
IQNETERSTSALKENVVNARIAIENKDNMALQYIENNMVELEFKIASLQEELYVDELTRL
YNRRWLFEKFLKDDHFISNGLLAFIDINAFKAVNDKFGHLVGDKVLHVMGKVLKKVQNTT
AIRFAGDEFLILHNSENEEEIHKILHTVNLNLKKTPFKHNQEIFYIDFSFGVAPFKAKDS
FKSVLETADLKMYDYKKSFK
>A0A3S4XML9|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MKTPEIPANEVQRLKALRSLHLLDTLPEERFDRVTRMARRLFGVPIALVSLVDENRQWFK
SNCGLGAATETPRDISLCGHAILGNDILCIPDTLQDDRFADNPLVKDSPHIRFYAGCPLS
YSGDLKMGTLCLIDDKPRQFDAEDAVALRDLASMVEDELRAFQASTSDELTQISNRRGFI
SLAGHMLHHCQMKGVKASLIFIDLDKFKLINDTYGHGEGDEALIYFSELMKQVFGYFDVI
ARLGGDEFVALMGNRTKSEAKQGF
>A0A840WYR9|diguanylate cyclase|EC 2.7.7.65|Rubricella aquisinus|TrEMBL
MPGRILIVDDVATNRFLIKAKLTAAYYEVMVASNGVQGMTIARGAQPDLILLDVNLPDMS
GIDMCAKLKRDPVTADIPVVMITAGGAAETRVQALDAGADDFLLKPLDEVTLLARVRSLM
RMKLVIDELRVRDESGAALEVSSMEQERPSRGLTAERVAGRRVMVVPHDPSEALEWIPAA
RERLGLVIEVGQSMSMVLNTVAINPPDALVVHREVFGSEDGLRLIAKLRADRNARGSAIL
LTLAADDVQTAALGLDVGANDYIQAPFDPMEMVARLRLQVRRKVFSDRLRSSVRDGLRLA
VIDPLTGVHNRRYLRNHLNTMFQDGRHHGGNLIVLVMDLDRFKMVNDRFGHGAGDKVLCE
FANRLTDNVRGVDLVARIGGEEFCLVMPDTGLKTAIRAAERMRRAICDQPFLLPDGTDLK
VTVSIGVAESTGKELDPEELLDAADRALYAAKNAGRNRVTLAGAA
>A0A4U9T9Y3|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MTPHGHLAGDGVLASVGAILKDCVRDEDFVGRYGGEEFMVITSSYEPLHIAAVAERIRSR
VEEFDFITESGEAIRLTISIGTSLYLPGMSVEKAIEMTDEALYDAKRQGKKPRGQQPFDV
AITVGGEV
>A0A0S4KXV9|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira inopinata|TrEMBL
MSILIVDDSPDDRELLKTILLSSGYEDVVTTDSAAAAFEYLGLDGSNEPPAQVNLILMDI
LMPQTSGIEACRRIKAVTRYRDTPVIMITAKTDPADLQQAFAAGAMDYIAKPINRIELLT
RVRSVLRLVHEIERRRSREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAAREATPLSLIMFDIDQFKTYNDTKGHMAGDECLKRVSAAISSAVNRPGDLVARYG
GDEFAIVLPGTSIEGAAQVAENLRRRVECLGIKNVDGGLITISVGYACLTPTRNTSPTDL
IKAADQALYQAKQEGRNRIRPAGTLSLVRDSHGN
>A0A855MQ30|diguanylate cyclase|EC 2.7.7.65|Pectobacterium versatile|TrEMBL
MLVSSGLDNTILISFFVIHTVAVGKTENILGLALGNAIRKSDYGIRLGGDEFCLVLIDYS
LTKSRDVIARAQEYLLTIDKEKLVAFSWGAHQLHQGDTLEVAMLKADELLYQHKPSKYEE
RK
>A0A0S4KS70|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira inopinata|TrEMBL
MLKILLIEDNETDALLTQDILAEWSVGSFDVTHVVRLDEAIDRLARDRFDAVLLDLSLPD
GYGLASLGQIQAANPRIPIIVLSGLSDQALALQAVQSGAQDYLVKGRNQGELLARSIRYS
IERKRAEERLTYLAQYDQLTGLVNRTLFRDRLLHAMARSKRLRQSLGLMLLDLDQFKTVN
DTLGHEAGDHVLKTAADRIKACVREADTVARMGGDEFTIILESLSHEDDIIHVAERITKS
IAEPFLLESGRASIGVSIGITVYPLDDHDIDDLLRHADAAMYRAKQLGGNSFQFHVTARS
FSPALRVKPL
>A0A0M7MK64|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MKSDAAQLDKRIAELLADPVYQGHPLHEALDALWRHTAEQMARIERVTQLSDAYQSMAHE
RELGLCDRFDRQLRRLTRIARISDHYQNMMRDLNSALQETSNRDPLTGLLNRRALMEMIK
QEVLRVSRGGSTFVVAMLDVDHFKSVNDRYGHETGDRALVELAGALGDNLREYDLCGRWG
GEEFLVLLPSTQPEDAQRVMDRLVGAVRALAITVGDGVLRLTVSIGMAYHQLGETFSETL
SRADQALYLAKQDGRDRVELGFPKRR
>A0A849BGS2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus gilardii|TrEMBL
MTSDPEPTLPALPRWQRVSLASALFFLLAVAGIALTRYPGNAAIVWLATAFGAGVTLHQP
PRERAWMLAGMLVAGIAANAMFGDPWWLALVLGASNIAEILFVAWLAPSISGGIGRASAV
PLARFALMLGATCTLAPVIGATIGAAAISIAYGQPFAGIWSTWWSADAMGMLMLVPLSVT
YSRERLRDTFPRTRLPRVAGLLLLTATVGGLAVVQTHDPFGVLSLPLVVAALFTNPFATA
LLTLLSMLVTVMLGLAAAQAGLVDAPQFLTHAMKLSTSLILVFPVCIAYLSEQNRRDRSE
LRGSERRFRQAMHHSAIGMALVSVDGRWQQVNRAICELFGYSATELSRIPFQQITHPDDL
AADLAQLDRLVAGDIDSYRMEKRYRRKDGNFIWTLLAVSLVRDEASGAPLHFIAQVEDIH
EHKLAQQRLEALSRRTELAVEAGRVGIWEWDIAAGTLSWDRRMHALHGTAAADGAPDLDG
WIALVHPDDVIRARHEMRQAVKGAQAFDTEYRILRPDGEVRHIRAMAVVSRAEDGTALSM
VGTNWDITEHHRLTEALFEEKERLHITLRSIGDAVICTDASLRITFINPIAEQLTGWTMA
EADGRPLATVFHVVDETSGQPIACPVAKCLQTLRPVYLEDGAVLISRHGERHDVQDSAAP
VLTPRGDVIGAVLVFQDITAARALQRKLAHSAMHDALTGLPNRIWFEQRLREACESAREF
DQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRSQVRPDDLLARLGGDEFALLLR
NCSVDQGERVCLKVIDAIRARRFPWEGRVYDVGASVGITAIDREAPPLGELMSRADVACY
AAKAAGRNRVSVYRRDESDARRHHRELQVAAGIHSALEANRFRLFAQEIRALAPGSGSTP
PAALPASSPASPPASHIEILVRMVDEHGSLVMPGAFIPAAERYDLMGHVDRWVIQHVLRD
FGARLLAVPGLSVSINLSANSLGEPFLLPFLHAELSNSVLPASRIRLEITETALINNMAA
ANRLVAEMRKAGCTMALDDFGAGLSSFAYLKQFPVDYLKIDGSFIRHLASSAVDREIVSS
INDIGHRLGIHTVAESVEDEATLDVLREIGVDYAQGYAIGRPMPLEDYLARCASGTPGET
AQRQPR
>A0A7H9K476|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLFDNSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSPDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPTLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A2N7R4S2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MKLFGSRSRPTLGSVIGRGHLIVALVAVAMASASLTLLGVLALRVYADHNLQLIARSISY
TVEAAVVFNDKGAATEALALIASTEEVADAQVLDAQGQLLARWQRPENGLFSELEMQITR
TVLEKPVSLPIVHQDREIGHILLVGHGGSLMRFLLSGLAGIVLCTAISAWVALYLARRQL
RGITGPLRSLAAVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKLNERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLAPLHKIEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVFPDHGATPGALLNAADAAMYQAKRLSRGAQFTAGSENPVVNLQT
RS
>A0A1V5M639|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin419|TrEMBL
MENRLVSKDKFIASVQEFITTGDGPFSIAVADIDNFENINKIFGYSMGDEVVKKLISVFV
QNIAPNDIMTRHGDEFNILLAKKGAERSFMEMEEIRRYLSDNTFTLSDKNKTDNVYITIS
CGIASYPRDAKNAVELFRVADSAMFRAKKLGKNKVCLSEAESMVLKSSYFTKTQVDRLSE
LSKESEKTEAFLLREALDDLFKKYSR
>A0A2M9WFJ2|diguanylate cyclase|EC 2.7.7.65|Pantoea rodasii|TrEMBL
MPTSLLPPRAGNPFLPVHLCFLAVFLFSAFLTVHEAVELKNNYEERQRAQLAEIQKNLDS
QFQESIDELMFYEKMLNYALMHPLDSSHTREVIARFQQQRQQTTWQLTLASLRSMPLNGV
SDSWLARDPLLVRNNDQINEELRAALELSFIMQFGDPAQDFHSRFWYISRAGFFISSRPP
QSPQELEESYGTMTQRPYFREQDPNNPLHGRLRWSEAYQGEFNEGLMMTVSTPIVSNGYW
YGVLSMDFTQSRIQALMTEARHSLLQGKLLIVDRSMHEITRLHAPDDKPLTPEQQDRLES
RMRQLPGGVMRLGTQFASWSKLKNVDAYIVNIQSLKQGMSQELGRVSLFLLAMWLLFVLL
LLVAHQVIIRLVRRMDDLSAKLTWRANYDGMTRLLNRNAFFEQFVLLAARSQQQQTPIAV
IQLDVDYFKKVNDTWGHAAGDQALIRVAGVISHTLRKYDVAGRIGGEEFCIVLPETTLAD
ARAVAERIRARLAAKTILVNASTTFSITLSAGVTGSEEQGDYHAESLQASADRRLYLAKT
GGRNRVCAEG
>A0A645I408|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MKAINDNFGHCSGDKLLFSLGNVITTNIRKDDFVFRFGGDEFVIVFPNADKEQATKIIRR
IQESISAINQKEKLPFYISISYGISEYNGNTKIKINEVIKNADIAMYQNKNLNKANMNQE
KNLVLN
>A0A645FJD6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLASVVYTMVAITLCTISSFHNEKNQLGEFISKTRLEQLSTTDFLTNTANRFRLEEEADR
WMNFCRRQKLPLCLVFVDVDNLKQINDTYGHVAGDSVLVMLSTLMQKQLRNSDTISRWGG
DEFVLLLPNVSLKNAISLLERLKASVLKTDFGVGVKVTCSYGVVEMGEESTFQSLLREAD
ELMYSGKREGKNRISYIERGEPQE
>A0A246HI38|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia|TrEMBL
MHNVPNLDEASQPLALAWAQTLTQTPAAAATLLGSLSAESPPGLAHHFYDVLLEDPRAGR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQADDSATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNADAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLREALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANATQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRKHIAQSPVQLANGQHLSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDQVVLATDTLPDAPGRQALQRG
>A0A645I187|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MSVLACDIDHFKRINDAWGHERGDMVLQLVSSTLKNNLREHDLVARLGGEEFVLLLADIT
LREAELIAQRIQRDLGSKNTVLPTGPKLTMSFGISSITKPSQFEQAMKEADQLLYQAKNA
GRDRVHVSGVFYPDISVDIHQQWNRPAI
>A0A645APV6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MTYLCTFLEYGELLEPAASETDRFPVLRELYDPKSDAWYKITTDRIKLVGGGYGLLHMID
DISEWKKHESQLRKSASTDDLTGTYSRGAGLIALNEAFEERAVTRTCVAFADVDGLKAIN
DTYGHTEGDFTIKTIADIFMGCVRKSDWVIRYGGDEFVIIFRDCTVEIANSVIARMHEKI
EEINHALDKPYRLSFSIGCTLVEKGFESVEELMAIVDRLMYDKKRVNRLKCCKTKPPAGP
YGK
>I4ZV37|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. HA|TrEMBL
MDNECMDMLAGQWQHICQNYSSDDLVHAFQFIQDNALILVEEFYKNMRLEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDEAKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQQYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMHIAENIRKFVEEGIITTAQGIQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A7W6K0A2|diguanylate cyclase|EC 2.7.7.65|Rhizobium borbori|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAENGYQALELCESTQVDVVLLDIMMPGID
GFEVCERLKANPRTMHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLISRVKSLM
RLKTLSDELRIRAETARKMGGEDVLKAFEERLDEAAQVLLVDGRGTSQERLIKTLKPVAN
VMAMSDPQAALFEAAETNFDLVIVNSNFEDYDPLRLCSQLRSLERTRFIPILLVTEQGND
DIVVRSLDLGVNDYISRPIDPNELIARCLTQIKRKRYNDRLRASLEQTIELAVTDPLTGL
NNRRYLDNHIKTLFARAAARGRSLSICVVDIDRFKSINDTYGHDAGDEVLKQFSSRIRAA
VRGADLACRFGGEEFVVVMPDTDAPSAVAIAERLRMGIEGETFILRGREQRLTITASLGI
ASIGPDVCTPEQLFKQADLALYEAKNRGRNMVVAAAA
>A0A2H6GKT6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin14|TrEMBL
MINRIVLPGTAAAWTVIMIILHGERFGINSWFVFPVIWFLGMACIITTGLYFNEKQNRPT
DFKVIELTDELTGLNNRRAFFAIARQQMEWGERFSERALVFFIRLNNLGKITEKFGSEER
DFALIMAAQALLSSFRGSDIVARYAEDEFIAFLPKSTLGFRDMIASRISKSMEMANHKGA
GDYRLSIDIGVAEFDPVAPASLESLIREAELPPPA
>A0A812AHK7|diguanylate cyclase|EC 2.7.7.65|Candidatus Methanoperedenaceae archaeon GB37|TrEMBL
MAVLDPYRIEDGNKIQEQLINEVYELRRQVAELKKIVIEYKKLEEKLKYLSFHDSLTGLY
NRNYFEEEMKRLNTTRKYPVGIIIIDIDNLKFVNDTFGHVKGDELIKYVANILSSIFRKE
DVVARIGGDEFAVVLPNVNEKIVQSLCKRIKDNCNRNNNPLKVSVSLGYDIQYGQYKDIK
EVFKMADSRMYKDKKGKKWVGS
>A0A0A8UX41|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MQKIKKKGEVIDQLIFADRMIILNKNLLLSIPANFSCTLLVYLSLYQIVNQKTLLIWFIT
TLSVFVLHGALFLFNCYRPLRLKSYLKIIISLVVIYGGLWGAAATLLIPYGLLLNLMFVI
IVIVGVTSGGLHILQPNYLVSILFFSLTTIPLSIWLFYQKGIIYWLLGTAMIIYFCFLSI
VSWMGYRLLNKNFKLRYENYDLINKLLEMNNSLEESESRFRCAFNSAAIGMAIISLEGRW
LKVNEALSEIVGYSEKELLQTDFQSITYPDDLDLDLSYVRQLLAGDIKFYHMEKRYIHKN
GSIIWILLNGGLIRNNENKPLYFIAQIQNIDAQKRAEQELMHIAHHDILTGLENRKKLEI
SFDHALAYAKSHQKKIAVMFLDLDNFKKINDKFGHDIGDLLLIEIAQILKSSLRSTDIIA
RLGGDEFIIALTELANICSVMEIARNILIAIEKPIMIKQQRILITGSIGISLCPDDGNNL
NTLIKKADEALYYVKSIGKSNFRLSSWSV
>A0A655PYJ5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTTEDFKKSTANLKKVVPLMMKHHVAATPVNYALWYTYVDQAIPQLNAEMDSVLKNFGLC
PPASGEHLYQQYIATKAETNINQLRANVEVLLGEISSSMSDTLSDTSSFANVIDKSFKDL
ERVEQDNLSIEEVMTVIRRLVSDSKDIRHSTNFLNNQLNAATLEISRLKEQLAKVQKDAL
FDSLSGLYNRRAFDGDMFTLIHAGQQVSLIMLDIDHFKALNDNYGHLFGDQIIRAIAKRL
QSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVRRSIEKLTVKDRRSGQSVGSITA
SFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL
>A0A380UDR7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter junii|TrEMBL
MKVHFKSLAKREKWNFSQLWEHEPLINWDMLKKSILLLILTALMSLFGILWDSFVLLNPS
TWQWVNLPLVRSKLLTNLIMLIVFLSLIIACYFYKDRVWVQEIIPILSVQIVTVLLCHTG
YLIGSFSPATMVTYASVVGVGLILFDRRMIYCALIPATIAMLFCNFLSMYGILQYAPIFN
PEILNQAEMHPFWVGSMFFFLLPILLACLYLFEILLQQWRTRETAIQALSRLDPLTNVMN
RRSISNQLEKLNQQVDQLYSVILLDLDHFKNINDHFGHSLGDEVLVNVAKCLTENLRDQD
MIGRFGGEEFIILLPNNSTTQAKSIAERCRIAISQLSFISEDHQEFSVSASFGISSSQNA
SESHLIISQADQALYAVKANGRNQVKIFSELVG
>A0A5W1RH30|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0W0TK98|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MASSLNSVTQNELQQVVFQLEQAIYNHQQWHNSLIRTLICRLPGDGHDLLPDAHRRCRFG
QWYYGDTLKEIQDHPEIINLGVSHQRMHQVTAQLLQKANTPEGITPLDYDHFANALEQMR
LEFSTFKNELEYLIHSRDPLTGALARVNMLSTLREQQEFIKRQGQNCCLIMADLDHFKKI
NDQYGHQTGDRVLAATARFLIENLRAYDKVFRYGGEEFLLCLPFTELDTGYAMIERLRKG
LEAITINDNTEHLIQVTASFGLALLEHQKPIEESIEHADKALYLAKSEGRNCVRIWK
>A0A5M9ILB0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MKAANVRPTLRSVIGRGHMILALVAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDRSAATEALSLIASTEEVAQADVFDSSGRLLAHWERPETGMLSRVELALAHTL
LEQPISQPILHQGRTIGSIHLTGHGGSLLRFLLSGLAGILICTVLSAWVALHLARRLLRG
ITEPLQSLAAVAHAARSERDFDRRVPPARIAELDSLGSDFNALLGEMEAWQNHLQSENET
LAHKANHDSLTGLPNRAYFEGRLIRALRSAAKAKEQVAVLYLDSDRFKEINDSFGHAAGD
AVLVAVAERVRAQLREDDLVARLGGDEFAILLAPLHKVEDAQRIAEKIIASMDMPIAVPG
STQVLTSLSIGIAIYPEHGVTPGTLLNAADAAMYQAKRLSSGGQQTAEPESPVVNVQHRS
>A0A1N6MAL9|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MIRSISRKLLLLLISTLLLFGLIIFSLWSLAQDQAQTRNNLESIMQIQLSIDSLRSQLWG
FLQYEDTDMLKQVSVAQRKLSEKLEQFAYSDRYTRNMIRMNEHLSVLVAQEIKSGLSAMT
REGQMSGRDLLHARYNMLVQNMTENLLDLQRKTLNQSRKNQQITLLLTAANLLIFSAFVW
VFALLIYRHFQYGFKALKHGFHELSQGKLSSQIETSHLDSEFVSLAELFHQMKSALRKTM
VSRDDLQTEVHRQTEELKAQKERLLFLSEHDYLTGLLNRRAFEEHLERALIKANRSGVKV
VVLFLDLDKFKQINDNHGHEIGDELIRSIGQRIHHHIRTSDFAGRIGGDEFVICLDLLEN
IDCIEARIQRLSEEISQPVSVNDVQVSVGVSIGMSCFPDDASNKQGLLSHADKSMYNVKY
SKRIERLDISDVV
>A0A3V8DAM2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V3CHQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Havana|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6J5E2L5|diguanylate cyclase|EC 2.7.7.65|Burkholderia paludis|TrEMBL
MMRPLLHVSPSRMSRPTLQSVLRRAHLRLAFVAIAMAAVSLIVVAVIALRAYAGNNLNLL
ARSLGYTVEAALVFGDRVAANEAIGLIASEEDVAQVEVTDSKGQSFATWQLPAGNGVARL
ERVVADLALPGPVAVPVVHDGIVVGQVVVRGRGHQFFGFLLGGVGGILGCLAVSVFGAYV
SSKRLLRNIVAPLRALAGVAHAVRRERAFARRVEPAAIAELNELGDDFNALLDEFEDWQN
TLRDENASLEHQATHDALTGLPNRVQFESRLTRALGDASATGQRVAILYLDCDRFKEIND
CLGHEAGDAVLVGVASRLRKQVRETDLVARLGGDEFAVMLAAVREAGSVCRVADEILSGM
APSIELSDGRMVATMMSAGVALYPDHASDASGLLRAADAAMYRAKRARPGSWQLAEGVAG
PV
>A0A730I9P5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V5ULT8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eastbourne|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A419IF05|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A291E1M0|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MIDNLIERISSALDAEYTLEGLVRQLLEMLELVTNMESTYLTRIDAEGSQQHIVFSRNTK
AMNIPEGLSVPWEDTLCKRALDEGRRYTCDVASVWGDSEAAKALGIVTYVSTPVTLADGS
LYGTLCAASSEQRVLTDHSEQVLQLFSQLIAQQIQNEQLMKKLQLANVALTTASYTDELT
GLPNRRAVFDQLPRLFSRAKDDARYVLVAFADLDGFKQINDVHGHETGDDFLCAIGKRLK
EGVRGDEVLGRLGGDEFIVAGAGPTEYSEALRATSAFRDRLSALLSGEYQLKSCVIDYAG
PSIGAIAINPAITTPDDALREADTLMYVDKKRRKNSATVS
>A0A0T7RVB7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A2J4RHE0|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSQAILVDGRQRPFASWHNDGLVSQNKISDVIS
KWLFPKPTVQTILHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINDLMKDETAQSHSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAVLLRDVHSETEVRALCSALSEQFIPPFNL
HNGHTASLSLSIGYALTWEHTSAENLQELADQNMYRMKHQRLQQTQK
>A0A7W3GWH8|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWGSISLTYTSINVVEAFTGALFLRKLLPWYNPLQN
LNDWIRVAIGSAVIPPLVGGLLVSLLAPGPEPLRNFFVWVLSEAIGALAVVPLGLLFKPH
YLLRHRNPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAQNPVALTTQHVGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMV
TVYEPQQERDHNTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFNEFFRASAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A0D6ILD8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MDAKTAVRGVECVDGPGRLGTGLVTPVIRRELSLDPILAELSASLQAAKSVEQLTRPILD
MLGAVTGLESTYLTSIDPQADRQQVRYARNAGTLQIPEGLSVPWSDTLCKRALDEGRMAT
SDVGACWPDSEAARQLGIQTYVSAPIRTDDGLLLGTLCGASASQRPIAPQAESILRLFSN
VIASFLEREQLVAQLRDANARLLAFALTDPLTGLPNRRALYEELDRLRGRALREGGSVLV
GVVDLDGFKGINDTHGHQQGDVFLQEIARRLAMTLRASDMVGRLGGDEFVLIGPGPALAR
GDAAPGHEAQRGDAEEAARSLEDRAAAATVGRYQLGEVTLPYEGASVGVVALDPRGLSAE
EAVRLADARMYDIKRARKAARTIH
>A0A379THW6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MLVGWSFVWPQLAWQWATKAPDPLQQEIYNLKADVILTGMWIALIGVNMLPAAALFRMMS
MNLIGAGGLRLFFAGRGLFLASCLATLQLTGLPIAMRSSSLEVTLSLPVIVLYPLLFA
>A0A379SI50|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTTEKRRAFCDAFETINGTHGVNLIRHNYPALHGTLQTAATQCTDN
IDDVFLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLKKHYVYFYDLINSQRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLSGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNITLKDLDSGKEIIINKSKNNLFQYVDYNHDILGGLRVS
FSLDLTYFIVSSWKALAFYLLATALLLNMVRMHFRLYRDVTRENISDAMTGLYNRKILTP
ILEQRLQRLVNTGTPVTFIAIDCDKLKLINDTLGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKSVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQRRS
>A0A380U746|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNWSTLKKCILMLVLACIIHVAWLGWDSFILLNPQYWQVVNLDIVRIQFVLNSIFLLTLS
GLIYPCYVLHDRVWVQRFLPYVAIGIFVISLCQDSYFVGVLSPMTMITYMCLLTVGLVLF
KRKIIYIMLIPATSFLVFSGYLSFIDVMPYSPLFTINGKLFYNGFWLFSMLYFIAPILVT
CLILFEILLSQWRHRERLIQHLSQIDPLTNTFNRRRIRQSLEYLHQQDPHNPYAVVLLDL
DHFKSINDQFGHHMGDNVLIAVSQELNDQIQKHDLVGRFGGEEFILILKHASLPKAYQIA
ERCRTTIEALVISNDEGQSIHVTASFGIAQSHHGLRPQQVLSQADKALYAAKASGRNQIK
CYLEINPGEIKYSAACADTQHISPN
>A0A5Y2S285|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A078BM30|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. CB2|TrEMBL
MGQETQARVADSWCEDIAQWAEHLPLMAACFDAHSHLLYCNTAYANWLGKTPTELLGKSL
DALVPHETLVTITQHIAAVLRGEIAQYERQGHHAGRQAKRWLRVRLVPFPPDEQGAVLGY
FCFMQDTTRLHASDTSLDLLRTSPGLTVWELDLQTGQLHAEQNWLDEAHRHEPKTFTIPE
WMGHVAPADLPALEQAIARISAPDGFVQTVETRFIRVDGSTVTTMNHGMVRERGPDGVAT
RIFGLTWDITELRQTQTRLQRSESRFRMLAELSSEWFWESDPNDVLIYITRSSRRASESP
LATLNLVGHNLNSLYPGQEFSPEWAQLRFLMEEHEEVRDLIVPFRLGPDQALLWWRIDAS
PMIDHLGLFQGYRGVVRDVTKAHQAEEKLELAAYRDTLTGLANRTLFEKHVEDAIAVTPP
GQSFAVLFIDLDRFKLINDALGHAVGDKVLVETAQRLVQLARPNNTAARFGGDEFLILAR
DAHDAAQALRMAMLVQQSLGEPMHHAERTLQTTASIGVAVFPQHGRTTAELLGRADAAMH
ESKMLGRNRVESFSVALQSRIERRSQLEEELRAAIANRRFEVHFQPIWSRKQNVLLHDDS
ATLEILRGAYEIAGVEALARWTRGNGERVQPDEFITILADCGLLDSFGPVMMSVALEGFA
RLRKEQGFTGTMAYNVSPRQLHVNACVSCIFDMAASFDVPRDKLVLELTENVEIEHNPDL
LAVFEQFRQMGVQLSLDDFGVGYSNLGYLTRLPVSQIKIDRAIASGVSTDRFKAAIARAT
LTMAKTLNLEAVAEGVETVADLLWMERAGCPMIQGWVFSRALNLQQTLNLLRDLRTQQTH
>A0A0C7KIV4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A7Z8C4A1|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDFFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A5Y0UTB8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Corvallis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7H9FXV0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A483V1E4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADGLMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A086IH49|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A7G9HT30|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAIDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLSVLLSLPV
LVVYPLLFAWVSYQTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A1W1KM12|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEEIHTECSAIM
QDADERMYEIKKGKR
>A0A827L8L7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDTP
>A0A0F3UA25|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYCITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A1U9T304|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSSHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0B1KJN0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1U9T567|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LVDWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3T3ZP86|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H0TLX6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMRHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVTSKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVE
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A787ZWN2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMAWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A626BFS6|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFKLH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6N9MTQ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTIRNAKNLSNKTLRVRFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2W6NZJ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQIRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2H9A6Y3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQ
HMAALALEQEKSRQHIEQLIQFDPMTGLPKRNNLHNYLDDLVDKAVSPVVYLIGVDHIQD
VIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRN
VVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNE
MVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIP
LAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHA
WGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTE
IKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGY
FFSRPLPAEEIPGWMSSVLPLKI
>A0A8H1B9P8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDVCLNIKL
ATVELRYCSSAMIWPWCRNCAIAFT
>A0A2X1NY84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEAGYC
>A0A792T3D2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFRTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0F3SQV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEKRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A8B5RMV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
VSWQHHPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEF
DNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDE
FAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSA
DLALYKAKKAGRNRTEVAA
>A0A377CG70|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTP
QIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A3L3TH10|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETPLSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFIHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0E1L8V9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0K4R9W8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0J8XS00|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVT
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A181VD62|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLEQYQQLQRSDKSIELRLARLKDNGANREELALLHDGLQIAAELQD
EQQAALAHVANGDAPAAIAILYGKAYETELERMQTQIDRFRQMLENRAAVAIDQATDRSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEEHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAEAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTG
>A0A181WAI2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAVAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDFFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSNELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNTTLVNLTRHETNLVIGGFALAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A729WJE7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F8XGN0|diguanylate cyclase|EC 2.7.7.65|Brevundimonas nasdae|TrEMBL
MAFDARVLILAADDGRIGPLAEGLDALGWRTVTARDLASAAATLQDFPLEAAIIDIASFA
PDAALRLRAAAEPRRLPVLVVGARPDTIEGADLVMSAPPHPAQAALRLEQLVRASIAEEE
YHLRTTTFSLRGVDLTARPDDEAPLRILAAGSADRRFLALSNLLTAQGVEVIAAPTPYTA
FDYLHESPFDAAVLWGAEDHAPALSIASGMKRNTRLYHIPLMLYLRGQTEMGLSELFNRG
FADVSAADTPEDETAERLLALAAAHRRHLSIRRALDSVRSLDVMDPTTGLFTPELFAAHL
GRIAEGARARRRPLSVCVLRVRETEAVAWARQGSWLDRAMPQIGAMVSRLVRIEDTPARL
AKEVFALALPATHAAQARLAAERIAAVIGCTAFDAGSERSPFVAEFDVGVAEMREGEAPG
ALLERASADLFEQTR
>A0A0M2F2J0|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLAAQKASEFADAFYSYM
LQDQDASLFLSSQQVHDRLHGSMSKWIVDILTNTGDSLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVTEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENSSMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIKGIRTIASIMTETDDYIRDHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYGSTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A3R0D8L1|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3Y8I421|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A485BV25|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MNKDFSQAPRPTFKRALRRISVISVVISMTLVWLLLSTASVFTLKQYAQKNLALTAATMS
RSLEAALVFDDSAAAEETLATLGRQGQFSEALVLDNQQNHFAVWRNMDLVRQEKFSGIIS
KWLFPEPTTQPIWHLGKVVGELRLTALDSLISHFLGISIIVLTGSILLASFIALLLTHSL
HHGIVTALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRTSLHDPLTGLANRAAFRNVISTLMKDEAARRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMNFVSKHHQAWRLGGDEFAILLRDVHSEAEVKTLCASLSSQFLEPFNL
HNGHTATLSLSIGYALAWEHASAENLQEFADQNMYRMKHRRIPQVQK
>A0A763QYZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A740KJU2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGMHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T2H561|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T8QB81|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWLLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V7XCZ2|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSTEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Q9MAD1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Moero|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFCGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1E3AEZ8|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKFRHKALTIKKEIFLMSFAFLATVSLVFSGVFLHILYKKNMENAGNSLRECNAQIVIYT
EGMFHENESIVNILSRADTIVNGGSGNPAAVLKIYDAILKDNSNITYIYSGYADGRLYIN
NYDIPDNYDPTDRPWYQAAVASDGVARLVYEDAANGEWLFSQSKKLVDDEGNVVGAVSVD
CSNELISRQLSTRYQYASQRSFITDLSGKVLIHPDERYINDTILNYMEKDSWDKIIAGKV
SYGEYQKNGIKAMAYFEQFPGTDFIVCTAIDAREVTQPIVWNMVHLLFMLAGLSLLFGFL
LSRVLLYRFGGPILELKRRIENVVRGCPEEYREAGFYNAELNGIADSITIIVKNIAKKEE
QRKEAEYTSFHDSMTGLYNRRFFSEELRRLDVKRNYPLCIICCDVNGLKLVNDVFGHDVG
DQLICRVAESLAGVCRADDILARVGGDEFALLLSHTSEEDAEGIIARIREGFPAENIRGA
QISASFGYGVKKKKEDSIAVILRSADQMMYRRKLTESEEMKQQTVANIIEASAKEGLVTE
LTEKEEHALEQLSAALCPGDEALLKQAYRLRKIGLCSLFQSNMKNEEEIMLSGINRRHTD
NSYRILSASGEYRGAAGYVLHYTEHWDGSGWPAGLAGRDIPLLSRVIAAVDAFVSENSDG
FRLKQHDGWYDPEITALLQNLSEDGIQQESAPDVS
>A0A1G3DX54|diguanylate cyclase|EC 2.7.7.65|Pseudomonadales bacterium RIFCSPHIGHO2_12_FULL_40_16|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRIGGEEFLLLLVDSDLTRALQIAETIRMRIQETLIRTAHGQSFSFTVSVGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A517P777|diguanylate cyclase|EC 2.7.7.65|Alienimonas californiensis|TrEMBL
MPSALDPPRSEMDYSALDIAIEDAASGVGLPFLPGPPPPPLRAATLIGVAILDRRLRYRR
IDAALAAVNGRASEDHLGRSVAEVRPDLVDVIGPILQQVMETGEPRLSIPFEGSARSAPS
GRRWLSSYFPLPPSAESLRSGRDGPAGVVAVVREVNEELVDRPHGVSDERFRELVTQTTV
GLAQVDRDGTFLYVNDRFCEMTGWARHELVGVRSQQEITHPHDAGRNEVKFARALKTGEP
YLSDKRYRRPDGRSVWVRNTTTVLPGPDGQAESLFAVAVDMTDRVRTQRALSRSESRLRL
ATEAGGMGAWAYDLRKGTADWSSEALEIYGGGFDGKPTREELQARVHPDDRPLLERVEPR
PADGGPARVDMTYRVVHPPRPGQKQGEIRWVRALGEQWFDEFDRPLRSVGVLRDVTTEHV
AADRLAQSERRLRLAVDAADLGIWEFDAATGLSAWDARTATLFGYGQQFQGGKRLYTHPE
MFAAIHPDDRERIAEKITETLDPAGSGKYEAEHRVVHPDGAALTLSVAGEATFVGAGPQR
RAVRVTGTVKDVTERRERARRLAEAEERRRLAAEAADLGAFDLDRRTDRLWWDPRCRAIY
DADGPEVVDAAAAYERVHPEDRDRLRAALEAACALGGNPRYQADYRIVRGDGVVRWARVY
GEGRFEQPGAPATRLVGCVRDITEERERETRLAETEERRRLAAEAADLGAYDYDLRTGVI
WWDDRCRGIFGAAAAEVTGVSAAFNRIHPDDLMRVRAAVDAACAPTGSNRYQAEYRVVHR
DGSVRWVRANGEARFDRPDERAVRLLGCVRDFTEDRRREERLRLSEERQRLAAAASELGS
FTRDLRTGEVWWDERSRELFDMTGETVLSADTLERMHPEDRRQVQQRVEAAANRTGPARF
RVEYRLPQPDGSHRWIRSQSEVQFEGPDGPAVRIIGYLQDVTAEKRHAKALEEAKARLEQ
SNDELEREVARRTAQLRTAAERLAEAGRQERDRIAHVLHDHLQQILVGAKMNLSVLTMTA
DDRTRELTERVADLIDEAIGESRSLSAELSPPILRTAGLGPALGWLAEQFRTRHGLNVRV
ETDADASAELDDSLAALLFGAAREGLLNAAKHARAASVRLKFERCVCGPECGLPGGSRGN
CSGVRLIVADDGVGFDAAAQAGDAPSGFGMSDLRQRVDLLGGAVDVVSAPGAGCTLQVCV
PLPSVP
>G4T1T3|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MYAKLSYRVLLIEDDPSDAHLVSRYLKLSTDVGFELTWVVSLSEGLAQLQKNEHDILLLD
LSLPDSKGLETVKAIRSSTHFSLPLIVLTGHDDTGFALDILESGVQDYLIKGRFDGDALI
RAIRYALHRSKLEQSLHEAEERWRFALEGAGDGVWDWNLLTNEVFYSPRWKALLGFSEDE
IDNDVNEWEKRVYPLDLPIAIANIQAHLDGRVDSYDCEHRLMCKNGQWRWFMDRGVVVSW
TDMGLPQRMIGTLSDITNRKNMEQELQQSKQFAVSTIDALSAHICVLDKSGAIVAVNRAW
REFYQNNAGASSNCISVIDSNYLAVCDCTTDDSSEQAAQMAAGIRSVMKGDMDVFEMEYP
CHSEHEVRWFNARVTPFNDNTEYIVVAHEDITERKQAEARDCLLIAALEAVGHGIVITDT
SARIEWANPAFGKLTGYTLEEALGKAPKDLVKSGKQDSLFYDDMWQTIRSGKTWCGELIN
KRKNGDLYDEELTIAPVTDDKGKITHFVGIKQDISERKRLEAELIQLATTDPLTGLPNRR
HFMERLGEEINRSERNNAHQVAVLMLDLDNFKKINDRYGHAVGDRVLKHFSAILRKELRK
IDTVGRLGGEEFGIFLPETSLSDAGVFAERLRQELAQTPLLADGQSIVTTVSIGISELIS
KDIQADSVLIRADQALYRAKKNGRNRVEFYNGS
>A0A653ZUM6|diguanylate cyclase|EC 2.7.7.65|Nocardioides sp. AX2bis|TrEMBL
MPWARRAVPETRHAHDHRPPALPVTGLREVRGLLRGVVRRLGSRGTDPLTGLPDRGVLRD
RGPLALALARASGRPVALLLLDLDGFKRINDLLGHHEGDAVLVEVARRLSTVVGPHDLLV
RLGGDEFAVLTAPLACVDDAADLAARVVAVVGTPLPVEELEVTVTASVGVAVLDRDGNTL
EELTRAADQAMYAVKRAGGDAPAPLGDLTDPVLAAVHGPRLVAELRDAVHAGELAVHYQP
QVDALTGLVTGFEALVRWEHPELGLLLPRHFLPQAERSGLLGPLTDAVLDRALADLPALR
RMAPGAGLALNVSARHMAARGLVTDLIDRVRRAGHDPASLVLEITEAATRPTPDVASLFE
EVHDAGVRVSIHGFGRDSSSLRSLWTFPAVRQIKIDPEIIATLLTDPTTERQVRGMVSAA
HALEVQVVAEGVETASAVTLLQELGVDTLQGRWLSAPADPAELARQASHWAAVGAAVRRT
APGSGPGSGEVAVTG
>A0A853SLI9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MRAAISESGLEPDLFTVEAAALAAARRMHANASASSAEQRRVLGELINHYERLMRETRRL
IGRSDRAERDMHLLNRQLQTLAGQLEYRATHDPLTGALNRGAVIDHASRCLAQGDMALIV
LDIDLFKQVNDDFGHPAGDGVIQAVVDCLKGLLGQETAIGRVGGEEFSVVWPTSSRDDAA
QVAQRICETVGRQRHAAPITRAITISVGLSWNRAGTAFETAYSHADQALYQAKREGRNCV
RQWLES
>A0A381H449|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MIAHELNALDLLSFPVWIVLPHTEELVFANTAARELTQEQTFSRLRKGIFSTYAQNELRM
YVADLHHHHDIVEILTVCRDGKEIALTCRLSVKTLSTQGDVIIFEGIETPTAQGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGLIVDANLAALNFYGYSHEAMCQKHTWEIN
VLGRQILPVMHEIARLPGGHKPLNFVHKLSDGTTRHVQTYAGPLEIYGDKLMLCIIHDIT
EQKRLEQELERAALHDALTGLLNRRQFYLLTGAKPYAPSVDDNGLQPAAHRYRSLQKH
>A0A2X2VM06|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MPHETTPGNWSWLRTLARRFGPGHVVNICFLVVMICSTLLTWREVVVLESAYRASQRNHL
ENVANVLDRQLQFSVDKLLFLRNGMYEALVTPLDFADLHDAVAQFAQLRGKSFWQLELDR
RRTLPLNGISDAFVNRTTLLTRDNDALANELSAALELGYLLRLAHSSTMLAQRTMYVSRS
GFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQRQNSARGVRWFSSPVPGGEVQQKVTVS
LSLDNERHWYGVLAMDIPVSSMKRFLEDAVEKDSEGEYQLYDYQLRLLATSTPEKRQVNT
FDDLELALLANDIEHDTHGGIRMGSRYISWERLDHFDGVLLRVHTLREGVQGAFGSISIA
LGLLWALFTMMLLISWVVIRKMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFERARVLIQ
RCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDRVLSHAAGLISGTIRSHDLAGRVGGEEF
CIVLPGTTLVQAAQIAERIRQRVNDKEILIAKGTTLRISASLGVSGAQENGDYDFEQLQS
LADRRLYLAKQAGRNQVCVRDDHPVPSPDTR
>A0A447UHS2|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MENIYSADMSRSAIEQDVVLHCRNGGRYDIHYSITPLSTLDGGNIGSVLVIQDVTESRKM
LRQLSYSASHDALTHLANRVSFESHLKEILLTVRDTRQHHALVFIDLDRFKAVNDSAGHA
AGDALLRELAALMLSMLRSSDMLARLGGDEFGLLLPDCNIDSARFISTRIVNAINEYRFT
WEDREHPIGASAGITLINNANRRAADVMSQADIACYASKKQRSGTCHRVRSAAGTGAQRA
GSHVSG
>A0A1V4XAC7|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaB.Bin038|TrEMBL
MNDVKGILEVLCRNAEIAEKFFAIETRILSIHNFRDLFDKLLTEIHDRFDVPRVWIAMTE
DNDVWRLLDRMTPGGTFGERLRMIDAEAFEGIVGDGLSPILANEGLERFSSLMPEGTRDL
SGSLAVVPLTYEGRAIGSLNLWDESPERYAPGMEVSLLRQLAVKVSICLANVMAHERLAM
LAFRDPLTDLLNRRVMEQVLRREFDRSKRYGTELAVVFLDIDRFKHINDRYGHDTGDEVL
KWVGSRLMAMSRQSDVVARFAGDEFVVVLPSTGADRAYRFVDRLQTFFLSTHLAHDGKII
PVSVSCGIATAADAGVTDAVSLLKKADERLYQSKNSKKG
>A0A1V5WIZ0|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MGKVPDKKLKVGILLDSADGYMNKRILNDCIDLAEEYNVLPVFFLGGVLEPAREPAGSDF
LYSLPHPGSLDALIVFPNSIAPWDPVTETRKILDRIPDLPVYAANEAMPGLFSVAINEKP
AIHALVDHLVLTHGYKEFSLITGPDAPASISRRRRQLFEEQLARHGISVPENKIVLGRFK
EDDGKRAVEALFRQEDSIPEVIISFNDQMAAGTIEELLNRGIAVPADIAVTGFDDVEETS
LLPCTLTTIHVPVWEMMTALFEKITGDLRGRKTAGDQRKPDAVYLNATFIRRESCGTLRN
DETHAVEMEELVGEQIESIYSPHQSRNKTFRQELENVLEETLTTGETDRFSEFSQKIVKK
ILRTGDISSSFIDIFSSQWTISLLKHDDNETRILINALFLDAIRLLVRGKMQTCARIHAN
DRGALEFSRNSTSILSRKPTMQEALEEIGKNLSMLGIERCILVLTDPENPEQGSTRLSYK
KRYFREIPTENFTKFPVSRLVNNGLDSITVPIAVLPIAINTDFFGYMVLSITENSFEDLS
LVQELVSRLIAGAASNESLSSQIQFLERKNTALSRLSTIDEFTGLHNRRVLHETGKDLFR
RTLNEGKTCCCIFLDMDGLKKINDEWGHPEGDTAIKTLAAILRKSFRSRDMIVRYGGDEF
IVLMFDIKKATVSSALARITRQLDLYNKSSGKPWNLQASWGVTVVPPDRITLSFEDLIEE
TDDRLYEEKQRRREAGLR
>A0A2T3Q7R2|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MKVKRKIGNKVCVLAFFLYLCVLLMSYIISDKIINNREVFSNSRVEAYLNTALNDLGHDF
KTEQEKLKWLSFYVASTGFNQKSFLLASDELLDGVKGSSNFQFAPNGVVTVTNPHVSDKR
AYIDLFSDQNRKEDALYAKKHRTMYVSGPLNLYQGGLAFILRNPVFSLHRTQKFLGFVIY
VSDISDSKIFSRISELSQYGYTVSLTTQYKQQAKNQILSTVDLKKDHYLFSINKTFYNST
WTMKIYSSNKMNDYQDLVLYITLLIDICIGIGLLLTIKFFEHYKNIHNERLLDHLTGLGN
RKALELELSREFESKQDFSFVYIDLNDFKFVNDTYGHEIGDSLLRQFSARLNRYIWSHNL
GMAFRVGGDEFNLIVAAKFDEESIRRGLDDLCKLPFQLDDVLYNLTISCGYAKRYPSDET
LEQVIRRADDDMYRMKAIKKRPMTVMPIS
>T0PMT8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MGRQRHNLLLVSITLLFLFSSGCGLYLQHRQEQLVDTFYRNIHWNISQVMLESQRFLYDL
RLYRAGQLDMETLSLDYDLLWNRLDIFLISSETADARQRHGLGKALAGLFEQIKLLEPQM
QAGQLREGTELEQLQTRIAEQTHQIGVVGDRILSSQEREASVNQIRSSLFWLQICQLILL
VTGGALVFALIRANLQNRRLSLLDPLTQLGNRRALQEQLTRSLQSSRAQALVVLDLKRFK
QVNDLLGYQVGDRLLQTVSNKLQQAYSGHAYRLGGDEFAVILTEDIQGMEEQIQALKQLL
HFEFVTRESRFELACRLGVAQVEETQDPNRLLDQAILALNQAKHDANGDIAWFQPGMLQQ
LQLTQRQLHQLRDWLAHRIPSPLVVDMPLLSSENGLRVRGVLLRWQDNLAPCEMSWLQEG
GILGPVIARLLQEHEQAALDEPQPLLIALNHQAQLAHVLAYLPATVHVEPILLLPALQQD
ASLLAKVNQRGCTLALSELGSSTPTLLAAGWPVRYWLPESASHTGLLQPLAQQLGLVRLI
PADVQAARQA
>A0A8G3WGV5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLSASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALAATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LNHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2T3QN37|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MAFRYIIKSNKKTRIPSFVCLCILFATALVGYIFHTVYQQNHMNNFKNLVTHQTYLLQNQ
IENDLQFMGSMANFLEASSNANWQNFELFAQPIIQNSKGLIALQLQQRVSSSNIHKFTQE
YRFLGKPITPYTLDNGRVLSFNDVKQDQTLFITTKVYPVNKENLSVIGFYSLGDRTRLIL
NNISHSRKANISDRVRLLQDKHSFITHLKAPLKGKDNLEQVIPDKIRLSSPKRGMLIYYP
VFQHNEMTAVVIGVVDVTIYLKTLITQAIENHHSAIQIIDTGFGANDSPILYQSPSWKST
DGVEITTQISYPNRSWLLHFKQSTDFDMNEYWILGAIFIVGLVIALLASLVTYQQLSQNQ
RLQYALTERTKELEFLVNHDSLTRLLNRRAFRLTLPLWIESKQFTLVGFDIDKFKSINDT
YGHIAGDEALIHVTQLVQGLLQKHEQLYRLGGDEFAILMPETDTTKIYEVLNRVRSAVEH
SPLIYQGAKIYCTLSIGAVVHSNQEAEALIYQSDLQMYKSKQQGRNRISITY
>T0PEJ7|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLQESDTIRISDVSEAVVHGILEVVSDGIWDWNVNTGFVYRNPGWYLMLGYEPHSLGNNV
FTWESVIHPDDIARVMACFDAYLTGSAPDYRVEYRCRCQDGSYIWIEDCGHIIARNPDGS
VARMIGAHRNIHARKLLYEQLESRNHSLEQLIAKRTAELVQLNATLQQKAEENRQLAETD
ALTGAASRYRLERDIQMECERAKRFHQPFSVIAMDVDDFKQINDSHGHAAGDQTLINIVA
RVQSHIREIDLLARWGGDEFMVVLPNTALADARRVADKLRELIAQSRVCEQLDITLSFGL
AEYRLNEPLSQLMVRVDRALYQAKLAGKNQIGE
>T0PTY5|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKQQATQMMWFYDRQQEQWSLSDHASYQLWQGEGAHPWAGQLAADDEPGFSDFLSRLYHS
HQPAQFIGHLNDEEGSVRHVLWSGQYIPAQQVCCGWLAPLDTTRSTPLPAELSQQLPLLQ
DPLLAQLAQALSARTGLDFFDTLVNQLAHILVADAVWLAERTGSDRLKVLACHGIDLKEY
ELAGMPCHQVYRRGEACVVTLEAHCQLNPQLKAGQRYYAQPLFDRNGQILGHLALLFSGE
IEIPNLGSVLTIFSVRMVAELERLQSDAQLRLSAVAFETHEGIIITDPDFKILRVNHAFS
QITGFDSQRVIGLHLGNELWSGLDGLGYELNTLNRWQGETQRLHFDGHTYPQWEIVTPVQ
DDKGVISHFVICFEDISERKAAERRIQDLAYYDELTGLPNRRQLHETLAQAFSEASRDNL
IGALLFIDLDHFKTINDSLGHATGDWLLKEVSSRLKRLVRQGDCLARLGGDEFVLLLPSL
SASPPQAEMQADLIAERLISEIAAPYNHGVQVLHIGASVGITLFPGREQGVDDLLKQADT
AMYQAKSAGRKTRRFFDASMQQQADRRLLIHNELRNALSQQELTLYYQPQHMVEGGDIIG
VEALIRWQPPGRALVSPAEFIPIAEETDLIVDIGNWVLHEACAQYVLWEENGIHIPQLSV
NVSAKQFHATDFVECIHDVLAATGMDPACLNLEITESVVLGHAEDTISKMSELKAIGISF
AIDDFGAGYSSLSYLKRLPADELKIDRSFIQDIPKDGDNMAIVEAVIAMARHMGFNVTAE
GVESRQQLEFLQAQGCHFYQGYLASKPLPVPYLERYVRRLTHNDNTCVVAEK
>A0A7Z8IF38|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMHSALETPLDFAVLRKAEESYLAKRHDPIWSVEIHNRRTLPV
YGVADAFIDGDELLSRDTPFSGNELMATLELGYMLRLANNNRGFAKRMMYVSRSGFFITT
EPLKNSTQALALYSQATSDAWFTRQTQRNNPARGIVWQTVPGDESSREIPVITASIPLDF
QRFWLGVLAMDFSVQEMKAFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSTHEQ
EMLKRAFAGENQGGIRLVTRYISWEKIRNFDGVLIRIHTIQEGVRGDFGSITIALVLMWL
MFTLMLMISWFVIRRMVRNMSMLQTSLEWQAWHDALTRLLNRGALFERATAAARQSERLK
RPVAVIQLDLDYFKSVNDRYGHHAGDRVLTLVASTIASHIREGDFAGRVGGEEFCIVLPG
TRLKEATAIAERIRIRVNSREILLGNSASLRITASFGVSCSEDSSDYSFENLQSVADHRL
YLAKQNGRNQVCADG
>A0A157SVW9|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPRNISPEQIAREWRALCERYPLDLRQHVQAVVNAQRQALATAFYARMLPDPTASFFLSD
ELVKTRLNQAMQQWLQEVFEVGVSGDFESAVNRQRTVGEVHARIGIPAYVVMRGVRRLDQ
EIYDLLAADGCDTPMAGATYVAQTTGLAIEIMCHSYAVSHERNARAEESYRMFAMAHDIG
AEKERQRAALLDWENQLIFEISTRISAAAGAPASTGNAAALPLLGKSEFGLWFAHKASHA
FEGAPDLPIIAAQVAEIDQLLSGSAEPAQPPTGPRLAELMGAIRQKAKSIGFLVDQLFQQ
AGHLESGRDTLTRLLNRKYLQVIMTREIDFARRNDAALSVLAIDIDFFKRINDNHGHDAG
DAVLQEVAQNLVHALRSGDYIFRLGGEEFLVVLVDVEHERAWAIAETLCKRMAAERLQLP
GGQTLQVTVSIGVATHDGHPDYQRLLKGADQALYQAKSGGRNRVASTQMDIADA
>A0A564I0V9|diguanylate cyclase|EC 2.7.7.65|Klebsiella huaxiensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVKSVLKNIAEQQAEALATRFYDFIFQDPDIARHL
TYDLVQERLSNSLAGWVKDILMSEKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSEIDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKTDINGALLSESEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSDDSEYKNTQSLLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVEIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGAETEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKMHEGGGN
>A0A157SK92|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPASGSSQDAATNGAPDLFKSENDALDKARSAFENPDASGQEYRQSLGELIGHFERLMRE
TRRLIGRSDRAEREMHALNMQLQALAQQLEYRATHDALTGVFNRSAVIELATKALAEGDA
VMVVLDIDYFKRINDEFGHPAGDSVILGIVTCLRRIVGDEGIIGRVGGEEFTVVLPGYQL
QQAVELAEAMRAAIAEHRFEPPVDRQITASFGLSANTGGTDFDAAYGLADEALYAAKRNG
RNCVEIAQPAPPGAGS
>A0A157S797|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MHVDLLTLYLLATGTLAVSAGLLFWEQRANPKRATTLKRLALGFGILAVGCVAALYRGSL
PSPLGSALGNLIILSGYLLVLAGVGSFSGRRYRAFSGIVLIGTAAMWALVGAAGEAAGWS
YYSSVPIALISGMTAWAMWRCQAMKAFPARHIVVAVAAIHTLLYAGRATILPWFVAHGGL
AIQAIASKITIYEGVLYSVALPMALLKVIRDETHGQLLRESLTDYLTRLGNRRWFFEEGP
RRLHACAGRGPAALLAFDLDQFKAINDAHGHSTGDRVLKTFAEVARDVLGPQAVLARIGG
EEFAALLVGDDARRARQLGEKIARCLPETIAQRIEGLAIATTVSIGMSVYQENLPTLPEG
LSAADQALYRAKSLGGNRLEEAV
>A0A157RCI9|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPRGRLARWLTAPGQATPHEIRVALVGTLFGTLPIFFGGVFNTVAVAGILAYRHPTLPFR
FWLVAEIIVCLVRWYVLVVSRRRAVQGRPTPTDLYILLAPVWGATVGYGAFVSAVSGDWV
AATLSFLSAAAMVGGICFRNFAAPRLVVVMIVFSLGPCCLGALAAGEPVLLLTLLQVPFY
LFAMGAAARRLNGMLITTMTAEREHSHRARHDALTGALNREGLSKALEQRGADPGKKDMT
LLFLDLDGFKPVNDAYGHEAGDMLLMQVALRLRALASPQALVARMGGDEFVVVDEVSEGP
ARHDLAAAIAESIRHPFSLSHGVVASVGVSIGSATVKWDGTDIDAALRMADTAMYEAKRT
KKTEPAVNAGSDAIQFADRDRRPT
>A0A2X4YZE2|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MFFILYRESNERYVRSYQNSIRDPLTRLYNRSYFYDTLNQRLTKVSASQPLSVIVCDLDR
FKRINDTYGHVQGDKVIQFAASVLQNNVRQEDIAARIGGEEFALLLVNIGANEALAIAER
IRLSVSEQHEGLPERMTISMGVFTTQDAHVAAEECVKRADTAMYEAKNTGRNRVVVWQA
>A0A8F6HCA2|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas indicatrix|TrEMBL
MPFFTDSTEVAVEGVGAARRIGWMRFVGNGLGALPIASIILERQADAALWVLLLLNALAW
PALAMLLTRRAREPAAAQFRCMIVDSLFGGAWIAFMALSTVPSALFAALLVADKIAAGGI
RLATRATLALVVGFVATWLALGLPYQPITSQRTVVLSLPFLFVYGIGLSVLSWRLARRVK
SQNRQLQRLSRMDPLVELANRGFLIQRAQQVLQTGQHLGGDACLLMLDVDDFKRINDSHG
HRAGDEVLRRIAVVLRQLAQPGDMPARLGGDEFAVLLRQRIPAEAMDVAEQIRHYLQEPG
APETADIQFSVSIGIAAAAGTGSAEDWLAKADKALYHAKRHGKNTASYAE
>A0A8J8BAN7|diguanylate cyclase|EC 2.7.7.65|Aestuariicoccus sp. KMU-90|TrEMBL
MTGRILIVDSVPTNRIVLRVKLATAFYDVMQAATGKSALVALKRHRPDLVIASSNLPDMT
GQAFCAALRRHAVGSRLPVILILGEDLPEERLAALAAGADDVLSRPVDDLVLLARLRSLL
RARDAESELELREDTRRALGLAEPPSDFAPPARVALVPACGRDEAHRILEALREALPDRI
DLIEPDDVLRDRNPAPDVFVLLESGGQGGEGLALLPQLRSRTDTRHSALIYVAYPHQRRE
AAAALDMGANDLLANGPDIAELALRIRKQAARKRTADRLRANMRDGLRAALTDPLTGLYN
RRYALPHMHRLAERSLGRGRSYALLVADLDHFKRVNDLYGHSAGDAVLVELAERLRNNLR
AADLIARLGGEEFLIVMPDASREAAKRTAERLCAVMTEQPVLLPDGAEVRVTLSIGVAVG
HPSDGESPESLIDKADRALYGAKSQGRNMVVMADTVTRLVAPGTTPLPPTYALEGDEARR
KAQG
>A0A7Z7QXY8|diguanylate cyclase|EC 2.7.7.65|Staphylococcus schleiferi|TrEMBL
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYL
IHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLK
QNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTDDDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>A0A533QGZ4|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MSAIPHRLPLVDLRADDAEIGRYAALLDSLGVALLAFAADDTPRLRNVAAEELLGDSTPT
WIDENGRPLRDDERPQRQVQATQQPVHQRAVGLRTPASTAVTWCRASAFPVFAADGSLRR
VLLLLADRQHRGRVVGDRQQLSTHDPLTEVFNQRHIDILLDDESRRARRYGTPFAVALIA
IDHFAARCQAEGEEHVLARTARLLCHSLREFDMIGRHGADSFLIILPNVRVNEAMVGLER
LRESIETGSAESGDTGLTISGGVSEYTGEDAPALIERLASLLASARESGCNRLCVDMDLF
>A0A173UPN8|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MAQADFMTGIWNRRHGEKLIEQALRDKVKGMMCIIDCDKFKSINDTYGHAVGDEVIIAIA
HTLKNACRKDDIVVRLGGDEFAMFFPDATERQGTVEIFKRIFEKIEIKALGGRKIILSLG
ACIYDGTGDISYDTLYSKADAAMYRSKKQQGFCATVHGAADEVFIP
>A0A1R1JU09|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSRAVPSSSDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVSTRLHKGMKGWLSGLLCVREQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALGQITEAVARLDDVVLPRLLQGGPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATREHSTFSVLLLDIDHFKAINDSHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTAREAALAVAEKLGAEIRRHAF
AIPEAGGLRITASIGVATFDGHPDYAYLIDRADKALYQAKQAGRDRSVAG
>S0G760|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MAGPHTHKLTLLSGMAMLLQSCSRETELYDVIYWYLPKIFSHVSGRICLQEKNKHTVLPV
FEWGKPSQTAVAPKPLKCEVLGKGLPVSSRKTSLACCAYCVPLKDKDGVIGALCVGNPQF
SLSEQYRKLALITAEYLSLSVSNIRLNHQLYELTIRDPLTGLYNRRYMDEILEKEFQRAR
RAGTALGGIMVDLDHFKILNDTLGHDAGDQVLKTVAHTLIHATRTQDAVCRFGGEEFFIL
MTGGTINDYLTRAGDLNTQISALDILWQGVSVGPITVSLGVAGFPVHANTPEILVHKADQ
ALYRAKKQGRNQVVCAQL
>A0A1E3GT61|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MTFFVAGKIAETEYFRLESAYTIMFNQAADAVVGKVNAYGEMLRATQGLFYVAPDLSRED
FANFYQSLKLEENYHGIQGLGYVAAIAPEDKQAHINAVKQLGLTDYNIFPEGEREQYSAN
LYIEPMTSKNIRALGFDMYSDSSRKVAMDRAIVSGAATLTEKVLLKQDGSASPVNGLLMY
LPVFIDPSESNLPVELRTVNSGWVYAVFRIDDVLKDVLATHTNVGLLKIYDDADEQSEGL
LFSQSGTPSKVNFSLQKSYDIGGRTWSFVGQPDRQFAENVSRSNPALIWLIGSVISLLFA
LVIAAIANSRANALRIAAQMTKSYRQNARRLALATEAAEIAIWEWEVESNMILLDKMASN
VFGLKSGTEQLEYSEFEKLIYEADLLAFRVAVEQAMQQHKTMEIRFRIHHGNETRMLHTS
AEVYFNETGQSVSLVGVSYDITEDWLHQKTILETEQRWKHALEGSGAGVWDWNVPNNVVV
FSEQLLSTLGYLPGDIVGKMENLLKLIHPQDIERVTADINRMLSGEKPEYRNEHRILSKD
GSWKWMLGSATVGERDADNNAIRVIGTKTDISWRKQAELALQQSEERFRNAFDTAAIGMA
IVGLDGRWLEVNGALCRMLGYSEEELMGKTFVDVTHPDDLDLDLEYVQKLLNGDLEHYQM
EKRYFHKTGDIIFVLLSVSLVRNEKGEVIHFISQIEDVTARKSESDRIRQMAYHDTLTGL
PNRRLFDERIGHTLAHAKRVGYPIALMFVDVDHFKQINDTHGHDVGDEILKAVADRMTHC
LRQTDTLSRVGGDEFVILLTEIKKPEDAKGVAEHILETVSQPLHVHTHDFRITLSIGVAI
FSGDLETETVSELTKKADLALYEVKSAGRNGVHIFGSNHIKAEPKAQKKNKV
>A0A1E3GT22|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MQHRHSSIRIVDNLAEITRHHDRQVLEKSLLKTLNELFPAQSLRLFRVRRHDLVHDISLL
AFCVNDVISSSDQHPKLNFETADELTAALTKAIDKEDIVSYRQSGNDGWNVIYPAFDSHG
EIFASLVHHCHELPSVNDQRLVHGILRVYANYLALIDKSQRDKLTGLYNRETLDEQITKI
LVNQSSELNKLMASPNDSRRRRYAIKHWLGVVDIDKFKVINDTYGHLYGDEVIILVARLM
TSGVIRDDDLIYRFGGEEFVVLLKAANEVDAMQAFERIRKVVANHSFPQLGQVTVSVGFV
EVSAQLSPTDVIGQADEALYAAKNEGRNQVQNYHHLVAAGKVMEPKKMVSSNVELF
>A0A398QEU4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2P9H5R2|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MKSKPMSDPDDSPASASTSDASLRALVAQTCDWYWETDSLLRITVAQAAGNGASELPLGQ
WIGKCDWEIPGDLVRPATWEEHRECLNARQPFSNLVVRRAVEGRSATVQHLCGAPFYGPD
GDFIGYVGIGRDVTEQYRAQDALQQLASIDPLTRLLNRQAFDERAQQVLSNAYALGSQCA
LLCIGLDRFRLLNSVYGYRIGDRMLAAVAARLRKAIRLPNLLGRRGGDEIVALLVDIDSP
DLVAKLARDIIETICQPERLGNIEISVRASVGVGFFPNDGGDLDGLLNAGDAALFRAKEF
GGGTHALFTVELARRTELRVRLEQRLRKAYESRAFRLFYQPLVSLPEGRLIGAEALVRWT
DAELGDIPPGEFIPIAEESGLIEGVGDWVLREACRQRQLWRQVGLDLPPIAINVSGVQMR
NHGFVDTILSTLDEFEVAAEELEIEITETGLMDCSTASRDNLLRLRGAGVKAALDDFGVG
FSSLAHLRDLPMHRLKIDRSFTVECMRDARTLTIVKAVIDMAHVLGLTVTAEGIENSEQR
DWMHDLGCDSAQGYFFARPMPAEEFLKRYLEGRSKDVERA
>A0A1D7Z8C6|diguanylate cyclase|EC 2.7.7.65|Pectobacterium wasabiae CFBP 3304|TrEMBL
MNELRNVDEQRDNGEQDYNQVVTSEWMQLITTTSQKSFNLLQTLAAQKASDFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGNHLTDLINYQRKIGQIHARIGIPVD
LVERGARRLKWQLYEDIAQVADDKALCFDAMRYASISMDIAIEIMNKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIATIITETDDYIRNYSNTPLLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKSVNDTYGHTA
GDNILKRIAEILYENTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHTIHL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAQE
>A0A398Q1A4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDLGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALCEAKS
EGGNKVIIHHI
>A0A1S9J5E6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLHTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAGDVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2P9H728|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MPAPLDPQPSPPRLPGIRRLLIVGISALLMVALAIAVSLFELKHDREVQHQYENTLAITR
LTFDAESLASRIRALEELRAQTGANAAQAGGVLQNAVRSLGIDATEWEQRIADAMGRDLP
VEAKMQLSQLRTAIRAMRAALDSRKGVPGSADLAQPSKASPSEPGADTDSDRAYLAAVEA
AQAALLSSVRASADRSVLAGYTISEVSTAIVVVASLLALLLGAVLAALVNRAQHESRATI
GVMGELLRTDPLTGIANRRCLDENLPIEMARAKRTGTSLTAAMLDLDYFKRYNSRRGHAG
GDSLLRTASQSWRSQLRPTDTLVRYGGEEFTLVLPSCDAAQACQLIDRLRPVVPDSQTFS
AGVATWDFQESGADLLRRADQALLLAKKYGRNRTIVSGREDQISLPLSSG
>A0A7U6Y7F2|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MHSLHRSLGIYAFVFLFLAVIGGWLVYDFRQERDRLLEDIARLAIHKSQVISRSFGDTFL
AADYVLRDVLGRIDVERDFSEASRNPAIRGQMDALVKEKVETVAGLSDLVLLNQDCTFVA
VARHPLQGAKSNQAFCSEPDIAPGQSLRIQYMPPDKSANGRSVVLMSRTVASSEGRLLGA
AMVVIDLEFAQNWISSFSTDRNDVLAIVDTSSTLLARNPPLPEALGKRAPPPSGTLSFAD
VGAGSTFMAASPIDGQERIFGLSRLERFPFVAIVGYDKARVLQGWQHRSWQFSIGFVVLL
ALSLLALRAHLTVVRQREDMRKLATTDVLTGIANRRHFMDVGQHEFARAKRHDRPLAVLM
LDIDRFKSINDRWGHPTGDRVIQKLAELLGVVARALDTSGRLGGEEFAVLLPETDASGAC
VIAERLRGIVEESQVAVIDGDFTLNFTVSIGIAVLHDDATFEILLQRGDKALYQAKEGGR
NRVVAL
>A0A3D2T825|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A486RYC4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHVGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A333HYS7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWLITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A0U3AV88|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MEMYLQRMKKEWLTLLDQTEPHIRQQAADIAVAHAQALSVEFYRVVLADPHAEEFLSNEQ
VEKQLKTALEKWLIDILSCNVEDVEGLMAAQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PVIIYGPQPSADKLQIYHFAINSIDLAMEVMSRAFSFSESSMAKEDENYRIFSLLENAEE
EKERQISSLLSWELEIIYKVVLDADIGNTLPLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LLQDFDGILSAINDTTKPLNAKTHRNKFLLQLRSTVSQITTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHANRVGTPLSILVIDVDRFKHINDTWGHNTGDEILRRVSQVF
YDNVRSSDYVFRYGGDEFIIVLTESTAHDTLRTAERIRSRVEKTKVKAPDGEDILLSLSI
GAAMFSGHPDYERLIQLADEALYIAKKQGRNRVQMWKPG
>A0A486D0A8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKQKRHSGRIHSLYDSLVHRDFPLEDILIRIINEGIKAFDLEIGIISRIENSKYTIIGSS
GHKDIHPGMIFNLENTYCQAVVAEKKIISVNNAGHHPLLKKHPVYLSMSLESYIAAPIFV
RNNIWGTINFSSKNVKLENFNSEDHEFIGLMAEGIASLLEIDILTKEKESIIQSLVESNQ
ILEKIFNNSTIGTAIVSEEGRWIKVNQALTNMLGYTKEYLLSTNFQMITYKDDLDLDLKL
LESLKNGEIPHYELEKRYIKSNHECIWCLLSVSMMKNEVNNSIYYISQIQNIDDRKKMEL
DVIQKQKELKRANEELEKMATFDSLTGIYNRRKFMIFFSEVKMKAECNLEPFSLAIIDID
YFKSYNDDFGHQEGDKALKYVALNLTDTLNKKGIVARFGGEEFIALIPGTTDSECLTACE
KLRKSIEDISTLQRKITVSIGAVTIFPKSDCNISFDDIFKITDSKLYEAKRSGRNRLKHA
HLEH
>A0A3S4G929|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQTLSVTVSIG
VAEHHDGRNG
>A0A447RGJ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFTVWLRRQLLSPGVIVC
C
>A0A4P0XPT6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKPIKQRELSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTW
GHLNGDIVLRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVER
RTWREDGLTVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRT
>A0A485G213|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWLITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHQQGG
>A0A483IU34|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLFSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAIRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A378AG27|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNRTFHRLRAPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGSSPPCRASLRSCMIYVKTATSPGGAGGAYRGVPSFRPGL
>A0A486UQK6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDINAQRQQVMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVAHRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQKQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQEPAAQQAYVAILRQALCGVYFLGEQRIDYEGASFGV
IICDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A1V5WX28|diguanylate cyclase|EC 2.7.7.65|Candidatus Cloacimonetes bacterium ADurb.Bin211|TrEMBL
MANHKVPLFSAQDERELRKQLSLLLHSSASNQTQDLINKLLQNYTPDKSKKEPSLTRFRY
LSAVLMEQLIILLQEQQDFKLSRWTVFFEVLNYFPFTSKNFMPLNLKDKIYCSASEYSAY
QSDIFIPLQLSYLLAQLEDSAIAYSLLKPLADRISFTSPFVHLIYHLALTRILILKGKRL
DFTKLWLKLIIEYYKEDGSETALYLIIQWLRMINWGRNASLKKKVLQAYSNDWKYNKSLL
SAFILNELVTLENHLLKPEEKIRYIHILLSLPSAFLSFEQLQYLYFFAGNYYSGVEQNFP
KSIRAYHHSTYYLQKSWLALQNLSQFLREHLSSEQIVQIMPYLEKKVISLANQINLQNST
YVDTLHKNYLLINELYHQVEALSITDHLTGLKNRHYLHNNLYHTFQLAARHKVPISFAIL
DIDHFKQINDLYGHLAGDYVLQTLAELLLSYFRKSDVIIRYGGEEFLLVLFDIKKENMLE
LMEGFRAKIENYEFIYQDNNFHITISIGCLCNCLSCLNDIVLNSYIEKTDKALYAAKEAG
RNTIVCFTE
>A0A377TW11|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRVTMAFSLAFYDQYAPMLLIDPHKDGRIVDANIAA
LRFIIIPMRKCALNIPGK
>A0A2Z2P1N5|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MKRNALKAGFTHIELLFIAALMLAIVMGTLTWGYRISEREQVLAFTSQSQQINNAAGLHI
AETRSFIKSIEAMHYVSQDFTDPDIEAFVKQVSEYSPYLHSLGMFQDVFAPMREQYQRQM
MGKIGDSFSIHHYSALGAQVPVGSQARILPIHSITPFDDTHKILLGADLTGSKEIEKMLE
SAIDTGESFIALAPVGWPFHTRYLLIQPLYLGKQVPETLMERRQLFTGGIWVSLDPAEMM
FHGEALSGTLSVTLSSGQRLSKIMISNTPASSQPGIKAGFATLKSERSWLMGSSSLQLSW
VMEPLMPVFDWIRTVAVLLILLIAVIAGLLIIYSRRRAQAELFDSLQVLNTEREKAERTL
ASISDAVISLDSARYIVYMNAAAARLLCTSGVGEMNKPIEYYLMMADSDDCDGSFPGFEM
ALAALPSQDTAEYDLSLRLPHLNDVAVKLTLTSMSNADGARQGSIVVMKDVSNERKLTSE
LEYRANYDHLTGAINRFHFETRLRSLLDATVDTKRTHALCFFDLDNFKIVNDTCGHAAGD
SLLCEVTAELQKKLRTGDMLSRLGAMNSVRSSVIVMLRKLWGLPAKSMSSSRTMFLNMQA
LPSR
>M1WKM4|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MLKSFSFIAALIIIAALALEDVIELQLAHKNRNEQRVAVSLQIATLRANIEKEIVDNLTT
IHGVADFISVTPDIDQKKFTQYAYGALHSKTLLKNIGAAPDLIMSFVYPIKGNEKIIGVD
YRTLPKQWPQVKHVRDSGKMLVAGPLSLIQGGTGLIGRAPVVVREGTKEKFWGIVSAVID
ADQLFERVNFSGLKDLDIALRGVDGQGEHGEIFKGRGTLFSPESESIKMSVNLPSGSWII
AAVPKEGWITSSPISPYSRLLLASFTAITLVLTYKGMKKNHEIQRTRKSLNEAQAIARLG
SWELDVRTDRLWWSDEVYRILGVAKEDVTPVTEEFFSMVHPIDRETVEKEFHDAILNQEP
YSREHKIVRPNKEIRVIHGQGKGEYDTAGKLIRTTGTILDVTERAVAREKLRNEQAKIKA
MAEASYDSLVMVDAKGIVLFWSPAAETMFGWSNEEAIGSEIHDLIAPLHYHEEAKSGLKE
FALTGTGKVMESIMEFDALRKDKSIIPVERSVSSFQIDNDFFAVGILRDVTERKKLEKEL
TLLARTDKMTSLYNRGYFMELAEHEIDRSLRYNTSLAIIMFDADKFKNINDQYGHDIGDK
VLIRIAETVTSVVRKADVVGRLGGEEFAVLLPETSMLDAQKVAEKIRVRIQTESIATPRS
GNVSCTVSLGIAEFNESIGDVELLLKLADTALYRAKAAGRNRWECATMNDYHFNI
>A0A4Y7RK31|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum propionicicum|TrEMBL
MWQLAGLFPALELDSLRELLTVVFLGVLAECLAVPFPHGQLSGGFALILSSFLIYGPAAA
VWVNGLAALIGQGIANRGNPVRTVLFNAGQYTLAAAAACLLFQLSGGVQGLVGITNIFPL
LIFTAAYVTVNHLLVYLYLLPRRHSSTGRLNWSDAIRWDGLTYLFTVPQGILIAMIYKYT
GLTGTLTLFFGVLALQFFLRFYVRLQVTNRELTTFYQVARFLEDKPSPVKLMEMVLRNTK
KAVPFHNGVAYLRQEEEEACLPAAATGPYAKQLLATTVFVGEGIIGQSLENRKPDIVFDT
RNDPRARHEEGLCQVMRSLLIIPLFSGRDALGVIVLGEKRPLAFDEKHLHIMTVLAGQAS
IALENSVLRQRLDQAVSRDTLTGLLSFNSFSSMASEICESSRESGFTVGLIILDIDRFKA
FDRHYGREAGEMALEELALLIVSSIRTDDITARYGGDEFALLLPGAGGRRLHEIAEILWR
KAREHTFLRDEGRSARLTVSVGLAEFPQDAGDAAGLFRAAQRALDKAKAAGGDCVESAAV
LIG
>A0A5B9P854|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MSRRLSQQLNRIESEALRLAPCAIIACDDENRIQLANLKAIELLCPDPAVQRDLSGVAAS
SIFPGVDFKADGPRGEKILLSAVQDRPSLEIQLVKYQLDGCRWTFVYFDRPENRRKRELI
LEKEASTDPLSGLANRRAFQRAMEANQHRALSLAIIDIDHFKLANDSHGHLAGDELIRLT
SRLLRDSFSDALLVSRMGGDEFSVLFETGNKNEIIEALSAFREKVSLSKLTDLDGVQFTV
SIGAVIAKVAGIESRTLLTHADQQLYLAKGRGRNQVSHVLLNDS
>A0A5B9PNN3|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MPEDTNKVLFPYLSTLFWYLREGVIFVDREYNVGAWSQAVESITGRDSAQAVGQTIRPSL
LSLHSSRGEPISADDCPVAASLQSGKIRTGDYRIIGPSGREVKVELTVTPVIDDNIVLGA
VILIYDSSVQLDLQRQLKDLYETSVLDPLTQVANRAEFERVLSETIVSCKKANDFNASII
ICDIDFFKSINDNFNHHIGDLALVAFANQLQEHVRAQDLVCRYGGEEFVILCAQCDVDSA
IDRAEQIRMSLEKTAQPMLDGKCITASFGVTQLRGSDSATDFFVRADSALLKAKEMGRNR
VVAVATPQGEAMKSVKGKSLSGVTWKPEGKRTLLSEEFVTQTPISVLVEKLRGFIMEFDA
EIRHVQSDFASVEVEIENRKDYSQRGRFRVSFEFCEKESAIETGGTRMKSYIKIVIREAK
RSWFATNCKELAPTLLAEIRHYLMLNDESNKIRVDSAGSATPGR
>A0A4U3FHF0|diguanylate cyclase|EC 2.7.7.65|Erwinia persicina|TrEMBL
MTGRWLCSWLRSKLRITEINAAAENALVISDKDSRYFRPKNLVHLCFAVVFVFSSILTVR
EAMILKSAYETRQRAWLVQAAGSLERQWQQSIDQMFFFQKMLQHALIYPLETDKAREALN
MFNDQRHDPLWKISVNTEWSIPLYGISDEAVRRVPLLNRGDSQRLDDELKAALEMSYILQ
FANPHQDFHSRLWYISRAGFYLSSVPDDNEETVTSYNTVIDRPYFTRARPELNPERILRW
SETYLSVDNEGDMVTVTLPVDAKNYWFGVLAMDFSTRAIHQYLQHALPKWQDVSVMLFDN
QQHPVAISEANHLSEHHLDKAQIAEIFRQVTPAQSGQLKSGLNFITWVRLQNFDGLLISV
QPLREGMSSETGRVTLVLILMWGVFSVVLIASHQAIIRMTGRLLTLQETLSWRANYDGLT
LLLNRSAFFEHAEKLSVFSERQQQPVSLIQLDLDHFKSVNDSLGHHAGDIVLTHSAAVIA
KAMRKRDILGRVGGEEFCIVLPDTGLAEAVEIAERIRCKLASKEVLIDAMHTIKVTASMG
VSSSEEQGDYQIESLQSVADGRLYLAKAAGRNCVSSGT
>D8FVN0|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MREFSTEGMPEREWYRMLWENLPCIYFVIDARGIVFSVNQFGANRIGYSQRELTSQLIFS
IFNSECRDCLEEQFFAFAQQTNSHSSPTSALREARITCKDGSILTVKSILHALPPLTGEE
IARERTLVSGNCQLPLILLICEILSVPITNVETSSEKKYSQLAEEALERERNLFTTGPVT
IFRWRPQENWQVEYVSPNVVQFGYEASDFISGKLFYTNIIHQEDLARVVAEFQSYSEAGA
TSFEHNYRIVKGDGLIRWVYDFTSVTRNSIGEIAYCDGYVLDITESKLAQIALRQQAERE
RLVGQIQARIRSSLDLNAVLNTAAAEVRQFLATDRVIIFRFRPDWSGDVVVESASKGTMS
ILNTNLYDPCFGQTYVGQYQKGRIRAIEDIYNAGLSECHVNLLSNCKVRANLVVPIIQSD
QTVKNSPSSSSVVNRGSQNQNSLWGLLIAHHCNNTRQWQSWEMELLKQLATQIAIAIEQS
QLYQQLEAANQELQNLASLDGLTKIANRRRFDEVLTQEWQRLIVEPIRLSLILCDIDCFK
AYNDTYGHQAGDSCLQQVATAIRDACREIPPERLYLVARYGGEEFAVILPNTGITDAIAV
AEEIRRRIQTLAIPHQQSFVSEYITLSLGVASADAAEALPETLIAAADKALYEAKSLGRD
RVVAKE
>A0A730GQK6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6B8N6L6|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MELDIFNPSRQLRRAVLFWLSMLLALMSLIIATLNVFFGVYHLLAIIQSLFCSFSLYVAF
NSYRSTASLLLSNCYVYSIIGLVYFTTLTYPIENGLFLWSFLYPVLFYLILGKRYGFVAT
MMGFISQLFLVVDKSFVDGVVSYFELIVNFALAYLSVWLASHILEVKRKTSEASLGQLAS
RDALTSVYNRHALIHNFDRYRQESETLPLSLLVLDLDYFKQVNDEFGHDIGDKVLVQTAA
LIDGLSDEHLVYRIGGEEFCIALHNTNIQHAMIKAEQIRMAIERYRFNNNEQPISLTASI
GIYQCDLYNDLESVLKEADKELYKAKKNGRNQVMVCNQKEQAMMTCS
>A0A140N6R2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain B / BL21-DE3)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0M6XNT8|diguanylate cyclase|EC 2.7.7.65|Jannaschia rubra|TrEMBL
MNTVTLHQDVLDGMIPMSMVVDRAGLVVHVGPTVGKIAAGVVGATVDRAVRFTHPTLPAT
YDAMIGHSGRKLRAELLTERKVGPGEERTSLRAMVIPLVSGQAMISFSLGANPAPALSRH
SLTAKDFFETDPIVDVLYLIEAHKLVLSEYRNLSGRLEEARVLAEEDAVTDMLTGLRNRR
AMDEHLSRLVGRKGARFGLMHLDLDYFKTVNDTLGHAAGDRVLAEVARILREEVRQGDLV
ARVGGDEFMLAFDNCADVDMLRGIAGRIISRLEIPIDWDGHVCRISGSIGLTMSGFYDEM
DTERLILDADKALYEAKRTGRGRLAVFTPVQSGTTAGGNC
>A0A6B8NJU4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MSGYKYGSCYYGKIEDVDWERWQKLVDMIALLFDAPAAFVTQATTNGIEVLVASEQAPSQ
YCPGAYSDKNTNVYCHQVVQSNQMMYVADASEDEKWSDNPEYTEDQFSSYLGYPIQWPDG
NSFGTLCVMDQRPTDYSDKLMTVLSFLRDTINSDLAYLYKANQLKVESRFDELTKALNRR
GFTESFERHISLSNSFNRSSMLMYLDIDGFKAINDQWGHSVGDQILKDFATALLKSVRKS
DLVARWGGDEFVVLLDSEQEVDKSRFVERLDESLKTSCQEHIPQYSIGSVELASGTDPSK
LTDFLCKADAAMYDNKSLNKTKR
>A0A6B8N6K0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MSYNRLLHAHREVNKLLTKLALGMGKAELNRRVVDLSEHWFGERRASILRLDEPTQQLHL
EYAPSLPDFYNQAIEGVEIGENVGSCGAAAFLKRTVVVEDINHHPNWAPFLSITEKANLR
ACWSVPILANDQTVMGTFAIYSSQPSKPSEEELEVLEMLASLYAVAWEKYQLEQQLHYHA
SYDCLTGCLNRRALLQRASDCLNTNLTYVACFFADIDKFKQINDKNGHEAGDVVLTAVGH
VFKHCFSESGISGRYGGDEFVAFAFSDDEEALRILHTELRESLAEITPLHTIEVNVSVGL
SIVNIERLDSIECLIKQADKQMYQIKHHH
>A0A1C3JPV5|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MQQTLFSIKATYIALLLYGAVGFIMGTLHLFSPTGHVIDQVVPLSCGIGITLLLAYFHKD
PSNRQITTIKCLYLANIIAFVIPVWYFVLGATWYGWPLIEEFPPISAIILIAMSVLIFMI
PKSWTRYVILMWISICAPIVLFLITHPLQLETPRGRDLMVLFGPGGALLFIVLSYQRELH
DRFDRIEGSLKYSRKQADTDSLTNISNRRGVLYWLSQYSTDTAHFTGLIIDIDHFKSIND
TYGHEVGDDILKQISVILAGSLSEQDCLARWGGDEFVILLPHATAARAKEVADNCLTHIR
KNTFPTVGQLTRSIGVAHNIKSNDIDTIIRQADACLYIAKRQGRDQMVSRSSEE
>A0A485CG17|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MIFIDLDDFKAINDRFGHQCGDSFLIQIGERLKANIRQGDLVGRLGGDEFLVVGTELDTV
QQQSFVATLREALRGVYFLGEHRINYPGASFGVTEVNPQIQDVESALRAADDAMYQDKKS
RRRDSFLNID
>A0A7X1BP47|diguanylate cyclase|EC 2.7.7.65|Citrobacter cronae|TrEMBL
MSKQSQHVLVTLPHPLLRMASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPVLGGLLLWLLLPKETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETVITLLVTLTLSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSMMLAADPSLLYIPKPNLTTSLPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLNNDL
EQLDMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRNSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAKNVIRDSLAARAPFKLEFRIAVKDGVRHIRSLANRVLNKDGEVERFLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDEKNHVASNVMSQADIACYAAKNSGRGRV
CVYEPQQSEAHAARSQLSLDEQRHTITHNPMLIIARGVASPRIPETFSFWLLSLRLGTAE
GEIIEEHAFRAGLVDSTLNQALDRRVFTEFFQSAAPAVASKGLSIALPLSAAGLLNTELV
DELLGQLQRSPLPPRLLHLTVPSNVIKTNPTQAISTLHRLRQCGCRIILSHVGRDLDLFD
NLKYHMVDYLLLDSELSASVHGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSHFAIN
>A0A011PU98|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MRYEHTFAQSAEFLRQAVKRMSQQEAGLHPFSYAIWYEYVSGINRDLQIALDARLASKGK
LDDPAACALYYKHVADLDAKTALRIGDSVGHLVDHVADSASHAGDQASHYSDSLERWSET
LQRPATTAKGAPPPPPGLADILRGTRDMQKAISDLQERLENSSREAQELRQEVARAREEA
LVDGLTGLANRKGFDLALAAGLQQDSPPGPGPCLLMIDLDHFKRLNDSHGHLFGDKVLAG
IGEMLRANVKGKDTAARYGGEEFAVILPRTPRGGAVGLAEALRALVASRRIRNGGNKQTL
IGNITVSIGIADYVAGESAADFIARADQALYEAKAQGRNRVSLAPRPQPNVPST
>A0A011P2L1|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MSDDALLRRLAAADRFLNRFGRHGIVGLSLVGALLVGALDYLTGYEISMSLFYLGPVALA
TWYGGRRAGIGIALISCFFWYGTQLATGNPYSNSVIPVWNALIRFGFFFITSSLLTALRD
GLVRQQQLARTDALTGLYGRRAFEERLEHQLAMAQRRKTPLTLAYVDLDNFKLVNDTLGH
AEGDRVLRTTGQVLKKTLRKTDTAARLGGDEFALLLPESDGHGAKRVVENLVDELREAFS
ANGRAVTCSIGVVSFLEPARSAAEVLAAADALMYEVKRRGRAAIAFRVVGGAFAEADREG
GAAKNGA
>A0A5V8HY15|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379K0D3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSDDAQRWKDKYLSSLEQQEKLERRWESRLDLLRRGLVRSSLAAEGADKAVDQCMQEMRE
ILRRDDMDAALGNLIPRLEKAVLDSEQRRQQRAGEAAAALASLIEQLQRLRPPREVRKAL
KSLGKQLEDATTHQYLLPALLSQLSNLQGQALTVLQAPVQEQPGLLLRLFGSRGETSEST
AQAPGSVTEATGVAEELAVELTPTPTPTPTPTPTPTPTPTPTPTAVAVANEPPPSVSKVA
SVPARHQVQDASPVLDSLPLPPGLVRQEQAGDSPFSLPSSEPGYSAVAPHIASSLRNLLD
ELELPARHLPQGEALRLRLEGNLNWYELVPVLDDLAVLVLAVTDSGQREFAGYLKQLNER
LAAFIKTLSEAHEGYSASVENARSFNQQLRDQVSDLQNSVQEAADLESLKQALEQRLEGL
LQSVSSHQRQRDSASDDVAERLQGLVKRVAEMEQEAQQFREHIEEQRQKSLLDPLTGLPN
RAAWSERLDLEVARRQRYGGQLLLAVLDVDHFKRINDGYGHLAGDRVLKIIAGELSKRLR
KTDFIARFGGEEFVLLIPATPLEGGVQLLETLRAAIEACPFHFKGEPVTITFSAGIAEFR
NGEAAEVTFERADQALYRAKGAGRNRVEQAA
>A0A379KBX8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MGDGNYNDHRDVGAGHCEGLRESGKRKLMRTILLATGLTLGGFAVLQALAGNYLFAILEV
LCTALLLFGAWRIERARHLHLWIYLYLIPTFCFILYIIVMPDASAAAFVWLYMIPLLAYL
LLGKQRAFLLTALFMCAGLLLYFTDNHLTLDTHGLIDLGNAALCGVLILVFVHIYDGLRM
QAYEELERLAQTDSLTGVASRGSFQHALQRSIQDAERSNGHLVLVLLDVDHFKQVNDQWG
HEAGDMALQHICQILQQRLRVTDFLGRLGGEEFGLLLRHIDSTGADPLVDKLRKQIAEQP
LEYDGEQIALSATFGLATWPVDGRSTAELYRAADRRLYSGKRRGRNQLVSADLPAELLLD
KFDVRL
>A0A653AXN8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MDQILSLLSETVPQARSLEQLARPLLALLGQLTGMESTYLTTINVEEGFQRVEIVRNTGQ
MVIPEGLVVPWADTLCKRALEENRLYSDNVAECWGDSDAAQALGIKTYLSAPIRSQAGHV
LGTVCAASSQQVACSPKVEPVLCLLSTLLGYFLERELLVEQLQAANAELATLALTDPLTG
LANRRAILRDLEHLYALAQRDNRYVLIGVIDLDGFKLINDVYGHQAGDHFLQGVASQLKR
SLRNSDSVGRVGGDEFIVIAQGASPDSAALDQELSTAASLMQERLSRATIGRYPLGEGVE
ALDYQGASVGVAAVMPAETSAEEAIILADGEMYRVKQQRKRQRS
>A0A8G0CBQ5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNQRMSLTWIICAPLFVVFVLVASFSLQYVEELNQKIDDSYADIQRQLDRAEKVVTELDY
TFMHNQLPAENILFRHSARVVDNVCQIKPIDGLVLAQGPSSNFTVPKLNLSYMLIGDASL
CDSKPSHDPSLQSKLSMAPMLSFLHDMDEYIYGVHYVDTSGYIISSPHTISEKVTYQQIK
DFISESPLWNHAIAAPNMIAVDGPYRSVIREQHDWLLTLILPVYRDADYQGLVAVDIGIS
ELLKRMPHLASGFGMIDLEERPLPSKAYRPYPLASHYADYHQIIFYQLDIKTELLSFLQH
KKGNLLVAALIYLFFTGILIYLNTRWERKHFEELAARDPMTGLLNRRGMESFLKGKRHSQ
YLAIAVLDIDDFKQINDAYGHDMGDRVICYIGEQIENHIRSSDAVARFGGEEFVVYVTAK
EKEQITRIMQRIFDAVCRDSSLVLESGFTVSGGIEVVESTTDRSFEDLFKAADEKLYVAK
TSGKNQLVY
>A0A8G0FX01|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTDQTRTSPLVNRLLKMISLCALGYLVIILAIIIPRGIQSVEQQKQELEEKLALSLSNSA
AIALYVNNYDIASEVMDALLLHKEINAVKLASVDGIVFERTTVPITFKEQNYWADANRYR
LDSPVDGNLIGYLMIHEDHQVIRQQAINQIIDQIAVVLIQFLVTFIALIWIVRRLVGKPL
TDLSQALSEVRPDHDRKVAVAAEDHHNEIGLVAKSINEFIDASHQALLRERELRQQIERW
ESYYRTIAEQDTLTGLKNRLGCERYVLHKKRASTVMALLLIDLDGFKLVNDTLGHAAGDE
VLREIAKRFYALAQTHFSDFVIGRLGGDEFAIYIPLNKFDLEPIESFAAQLIESSSAPIV
LAKQTAQVSCSIGISHMNSLHIDLEKLLLQADKAMYWVKYRGKHNYHIYRTGEELQPLPC
AKELKQDQFR
>A0A655QGR4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLLNAFSRRVFLWLGWLLISTSSLAATSTTYKVATEADDVVTRVLFDSIAHHFNLEIEYV
NYPSFNDILVAIETGNADFAANITYTDLRAQRFDFSRPTNIEYTYLYSYGGLRLPELRLV
GIPKGTTYGTLLKEHYPYIQQVEYEGHLEALTLLESGRVDGVVDAINQLKPMLLKGLDVQ
LLNDQLPIQPVSIVTPKGKHSALLGKIEKYAHSAHVQRLLRESIQKYQLDIRKQALRQSV
VESGLNVQRVLRVKLENNPQYALYQPDGSVRGISADVVFQACEMLLLKCELVSNGQETWE
SMFDDLQDKSIDILAPITVSQQRKNLAYFSESYYHPQAILVKREHYKDDVYSNVSELVAE
RIGVIKDDFFEELLQQMLPNKILFSYASQEEKVQALLNKEVDYIVLNRANFNLLLRESTE
MLPIVEDTMIGSFYQYDIAIGFAKNPLVATLAPLFSRAIKMLNTEQIIHTYDYQPNWRAT
LLAEKKYQRSTQWLFAMAFIVLFMVAFYLHGISHTDNLTKLRNRRALYNRYRRGLSPRLS
LVYLDVNTFKSINDQYGHEVGDKVLKQLAQRIEAVWRGRSYRIGGDEFILIGECSAKRLE
HVVAQCERFMFVDAERDVSFEVSVAIGIAKNRERTESLNEVMHQADIAMYRAKAESTQSP
FQAASKVKGLHIV
>A0A517YZE0|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MTTPSPPPTPSSDPSPADATPPDSFRFDEDLCHVNRSAPKVWNDASLRNKVTLIIIVSAT
AGAGIGILEMKFGHLTWPLFLALAFVISGLIAFARTWVVSPADQLITNILDICTNTSPRT
IKRLPTERRDEIGQIARITQRLAVSAVKDAQEIAHLRRTLTQRIEHATRRACSQLENLAS
RDPLTELGNRRALDEQLDALYAAAKATRTDLLAVMIDMDNFKQINDLLGHDAGDELLVLL
ANILRGSIRHDDLPVRLGGDEFLILLPGCPLYRAQQLADNTRKLFVRQAKMSFSDSKLRA
TPNLSIGIASMNHDKAEHGDALLKIADGRLYKSKHSGKGVTTMPTNTQPHMTDDQVSNSK
RFGNDDQENNRRVG
>A0A655Q948|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MKELGYTMAQIPNIETWFERAYPQIDYRQEIVAQCQKTVDEARAQGEDVAQMPALIMCAD
GVQRWFSVSAQIEPSCRDDLHIITFRNIHDYKISLAEAERQSQIDPLTQLKNRRGFFTWS
EPIAPETLLGLIIFDIDHFKQINDTYGHPAGDYVLRQIAGLLEQNLPPLSCCVRWGGEEF
LVCFECDDMANVIGLAENIRDYVESHTLMWQGQQIALTLSAGCTMGAMMSHNWDNLLHTA
DQALLSAKRLGRNRVIADR
>A0A811SXG1|diguanylate cyclase|EC 2.7.7.65|Shewanella hafniensis|TrEMBL
MPTIGTEKYTAEWLALVNNLSRSDAGQLEHLIHQNQHALSDTFYQAMMQDSSASEFLSND
LVQKRLKASMQQWLTDMFQSQTTEHIQALVAQQIKIGEIHARIGVPVHLVLNGARYLKTR
ITQLTSHALASHASILIDLAMEIMSQAYSNSHERNSRSEEAYRLHAIAQNIAHEKDKQRA
AFLDWENKVMFDCASGVDAALLQPLYSSEFGLWFRHKAEHAFAGAEEITLINDGINHIDN
VLLPLLALPSLQADTKKLQCLRELREQSKSIRYYLDLLFEQNREVESGRDVLTRLLNRKF
LPAVMTKEVNYSRRNKSQFAILAIDIDHFKTVNDSYGHEGGDLVLQHLAALLSNTGRGGD
YLFRLGGEEFLMLLVDINAREAALSAENIRRKVERETFLLPHNQQLQITVSIGLAMYDGH
PDYQRCLRAADDALFAAKRAGRNCIITAIDKADS
>A0A200LC04|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A822TII9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSP
EQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGN
RHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIE
KVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLL
WRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVL
FWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVM
FIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQ
IAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A7Z8BNY4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8B3KGS4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A7Z8FEB9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A0E1CFY0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A8B3KCS6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>Q46VS6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)|TrEMBL
MWRRSLPQPRWLPRLAVMRPHRVVVGCFAVVLLLALVVGLRDVYLVRERDLRARQHNLEL
RALGVEAVLEGERRRLEYLSTYAERLFEIQASADAVAPDAAIRQAYAQRNATVWQMKLPL
DGPALIGVGPAGLTGLRSFDRRDPDLMADLYVGRMISELLGLSIRADHVQGNAIFISSNG
FFVAYPAIDPAVAPSMMQRFDSMPYYRGQTPEVNPGRELYWVPMYDDFQSKRRMTTLSVP
IYAGQQFRGVVAIDVEQKRLDELLRAASDPGAVQYMMNAHGDVLAISDDPVRKVQKWPDA
VPGNWKDFAPADLFARGSGMVKHDGDYLLFHRAPQSPWLLMDLVPARKLYASMFASMSRP
LLMIWVLLPLLLWITLKVVTQLFDHYIALGEKLQEIARQDPLTGLANRRRMRELAQSEFE
RQKRDGQPLALVMIDIDFFKKVNDHWGHASGDKVLVELARTMRANLRNVDQPARLGGEEF
AVLMPNTSLAEAAQSAERLRRAIAACVVEADLEACVERADRIIRFTISVGVAEARGEAAD
GVPMTLDGLAAIADRRLYDAKTQGRNRVVSDDNAHAAAVPQVQA
>D2AEN1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSRKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>A0A822W8E4|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MELEALLSLFEGSLRTIPFNILAVVVLALGFIYTNEVPIKLIIIWFFLILILSVIRWVTS
RIIISKEFYTTKGKQSLIGFLLLNFLMGLAWSLSYFIFSPYLNNTNELIFALILGGLSTG
AIASLSIYLPAYYAYVLPMNFPIIAYNLYLFQFDKTIFAVMYSLFLIIVLLTARLNSKLL
SKVRVLSITDSLTGLFNRRHFDVVFNNELSRAKRNKYPISLVFIDIDNFKYINDTFGHSA
GDSFLIHVSNILKQTLRRSSDSMFRIGGDEYAAILINMTPNEVTTVCVSMQEQFNKKNQY
KNVSLSMGVISIGSMRVIDQQSAITAADKTLYQAKKAGKNQIKSKSLG
>A0A0M2WIA6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MLPPAAHAQVGNLEQYLAAVRDDGRFVPARALQRLQEVETQARSAPLPVRAEFLTQLSNA
RMRLGQNDIAMQLAEELIAYARINKSDVALAKGMLNKAYITFARNERRASHLLAFEAERI
ANGTDDLPVRVQATISAGQSWAEEGNFPFALAKLQAAVDLARQSKSPSSLAAALNALTLL
YTQMREYDKGFEVLDELLAVSSTLASPGRMAQAKNTEYGLALDAQQPQRGQRALLAALAL
ERQLGARAMVAVTLVNLSDSYLKEGDYARALRYANEAITAARLVNDEQVEATARLNIGQA
LIGQGRLQEGKQSVATGLAYYERTANQPEMQAVLLEYGMALEKAGDLRGAVTAYHRERGI
SNQLFEQQRQKAVYELQEKYEAEKKQRQIELLSRENQLKSTEIDNRRLQQRVWWLLALVL
AMASAIVGLLYRKVRHANVQLKVKNQELKRQSSRDPLTALYNRRHFQEFMRSHAGKPQPS
YAGGDVVGALFLLDVDHFKHINDGYGHAAGDLVLTTIAETLHDVLRETDMIVRWGGEEFL
AFLPAVARDGLDDIARRILNGMAAQVIHYQGQTIQVHVSVGFAPYPLAPLGRPLTWERSV
NLIDMALYLAKAHGRNRAYGLRGFQNVEKTTLEAVEQDLERAWRDGFVDLSVVLGGTDGV
DGASAGTAAQGSQAGASEGVAAAAIT
>A0A378JPN4|diguanylate cyclase|EC 2.7.7.65|Legionella beliardensis|TrEMBL
MLQGPNTDVNTLRRIKRSLVLKRPARVELLNYSKDGQEYWLDFTVIPLVDKNGEVSYFGA
IERDITQQKISQDNLYNLANKDYLTGAINRHHFYAVAAISFANHIRRNLNFAIMIIDVDS
FKHINDTFGHLEGDKQLKLISSICLSNIRQTDYLCRFGGDEFMVLLHGVDNKELIIKANS
ILTAISNNQNIKTSVSIGATLIDKKDTSINDLIARADLALYRAKEKGKENVCVL
>A0A7H0MF03|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. SMBL-WEM22|TrEMBL
MRHSTLNPLPGQGKDAGRYDDPAWVVNFCFVIVMVCSTVLTWREVIVLENAYKTSQRSAL
ENVSNALDMQMQVGIERLLFFRHTMQAALQTPLELNILRKRQGEFESKRMLAEWQIGRDN
QRTLPVYGVSDYFVAQTALLNRDNPNLHNELTAAMELGYLFRLSTHAQMLPRRAWYISRA
GFFITTETQTSEETIVPTYYRLLMRPWFNGQQKQENRGRGVRWFSDLTPGSEHHGDVTAS
VPLDYQGDWLGVLGVSFSVEAIHALLMNASHGRESDEKGEYLLYDNHLKLIATTSPFNTL
QRVFSTEERARLSAEMENKSHGGLRLAARYISWQKMKHFDGALVRVHTLREGIAGDFGRI
SIAMAILWLLFMVMLLTAWGVIRRMVKNMYAMQSTLQWQAWYDPLTRLCNRGVLFEQAKT
LSQQARAQKRPFAVIQLDLDNFKEINDRFGHQAGDLVLSHTAGLISSSLDEQQVAGRVGG
EEFCILLPDCTLGEAVTIAERIRQRIASKEILIHKHTTIRISASLGVSEALKEASHDFEH
LQSVADRRLYRAKHNGRNQVCARDEAPKS
>A0A6P1PKK1|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MLHLLTLSSLGRDLFNIKMLIVVLITIGLITLMTILTYLLEQQVHRRQNRYWTIVAHGAE
ALSVLISMILLRQIFITLNSGSIISWTYATVQLTILLFSLNTMRNLAVEIINLLMPLFIY
GQAIWLGHSTQYLPVFLAMAIILISTVVYITHNYQELHAIQWKYLLFQILYSGTWWGVIW
SVHPFKLSHTLVIILAFVLYMWLIRLAVNRVQKFFNEVLTFDQQVNYDELTGIRNRASFD
THAREVFAAYQHHQMGPVTMVMFDIDHFKAFNDQYGHLAGDAVLRHVAHFVELELNQRST
HGQIFRYGGEEFVIIFRGISALETGQIMRTIQRKLKTVPIKFNAQMLNVTVSIGISELQP
TDQTTVESQLLTD
>A0A737Y2Z2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 30:1,z28:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5E4SIA5|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MNAPNTDNYDLESEYEALLSFMYLSPVGIVRSDKSGAVDMMNPLAAQLLMPLIRGGNIEN
IFDSLACVAPELRNLVASFEAERGPICENHRIFVTPVKDDAVVLACSIIKVSADVLMMVL
TDISRQVAAERRARQTESWLAGIYTSVNDFAYFTLDAQGCIDTWNPSIERLTGYEAADVI
GHMLSRFYADDEIVLHRSPEHMALTRDDGWHVEEFWCKTRSGRRYWGQLLVAVLREEDGE
ISGYSAVLRDITERKIHSDNLARLLTTDHLTGVTNRAHFFEIGESEVARSKRNGRTLSLV
MLDADHFKQINDNAGHQAGDEVLKRITDEARALLRRSDIVARLGGEEFILLLPSTTAQEA
MAVAERLRVAVEQAAIETAVGQLNATISLGVASLEDENQTLQDLLAAADHALYDAKQAGR
NCVRGFVVPTEDAANVVGESGNAVST
>A0A653KEG6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MSKDSFAQSAAYLKQAVPLMIKYQIPTTPDNYTLWYNYVSASMPELNQAIDQAIKLQGTC
SLTTCERLYHQHLAAQDEQQMEAMKLSLAAMANELGHTMQDAISDTGMFQEMLDKSFDRL
SLIDDEGLSLDDTMGILRDLVRESRDVRMSTMHFRNQLSNAEKEIKELREALNETRKLAN
EDALTSLLNRRAFDLEIDGLIRSKQPFSLILSDIDRFKNFNDEYGHLLGDQVLRAFSKRL
RETCKEGVTAYRLGGEEFALLVPMRNLALSRQMAESLRRAIEKMSILDRKSGRRIDHITA
SFGVGEYNGQETGDALVERTDKLLYKAKELGRNRVMPLPS
>A0A2H6FFC6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin07|TrEMBL
MADRRKYQKKKGFIDRRTHPDRRRDKQSHKQQWRYPSWSEQRLQYITRYVLLVTGLIYFN
GMFEYSSSWMSITQLNLFLFGYVLFVTISFIFAHIKHHSPLRFRIAMWVDIFAVSIGVLN
DPFVVPLCSLVYIIIVLGNGMRYSMSLFVEALAGSFASAMIVLTMRYAGSVYSITPGVVF
LYVFATMILVYSYILMQRIDVAHQNLQESSRIDHLTGLLNRSALMESVKSCFSCLETGNG
NDRLVVMFADMDKFKQVNDTLGHAVGDQVLVEIANIIRYSVRGDDIAARYGGDEFVLVIR
DIGMGQADMISKRIQESVRTWGRENGIDVSLSIGIGEAPTHGNSFDVVLESVDRALYYSK
STHGPGGVCHADTAQVQP
>A0A1V5C507|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin050|TrEMBL
MKDKNKVKDQLDKEGTAGLKQSKHERKRAKEALRESEDLFRDAFENHAAVKLLIDPDTGN
ILDANKAAIDYYGWSNDQLQKMKIWDINILSPDDVKKEMEKARTLRRTYFEFRHRRADGS
IRDVAVFSNNITTKGKAILHSIIHDITDRKETEKERDKLIVELKEALSQVKVLSGLLPIC
ASCKRIKNEEGQWEQIEVYIRGRSEAEFSHSICPQCLKTLYPEYSKDK
>A0A8B3ZQW9|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MEMYLKRMKDEWVALVEQTNPHIRKLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGNCLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDLIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A8G1C0E3|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARQPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A1V4IE39|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MRNINNKYQIEYELNIEENFSNYLVFDLEKNERYALCILKNDFTYEKTREYLLSKFKTIK
NLNFKYITNIISIEVIYSMNGIKLNRPQYGYLMEYTESKIDTQAYLRKCTPLKKLDIFME
LCAAINTLNMQGYIFDDITIKDIRLIPTSRNNVTIEIRNLLQNELRKFNLLNSTINSLPY
QYSMEAKDEGNANKDNIGQVVKLFNHIFREEELQSQLIELNYVKKMYNRVNSINKSFNIK
HFIKDINKKMKKEYKLFFNDALVKIQDNLDTIGMEEELKIVEKNFQKILESKEKYKIIAF
NGEDGSGKSRLLEEIRYRLSNKYFKDIIYINDLININLDKEEKYNYIVNYILDKVDKTLK
DKYEIYIKKFISILIENNPVSSERKQNYQLINRMGRFVSEYTMTKPFIIIIDDLDERSEV
FKLFIRYIAFLNNNLENTMIIFSMNESRWDEKNLRFMNELKGDEQYEEYKINYFNQYNTT
KMIKSMLNTNCEIDKLSTKIYSETLGNPQYISDVIKELHENKSLYFDGDSGKWKADIKSK
DILIPKTLENKLETSISTLEEKEIEVIKKLSIFENPLSEKIILENIITEVDDVIAYKKLK
LNGFLTDKISDQGILIGFTNNLLRNVVYLKLSEEEKKNLHSNASIFMEDILFETDYYIEE
FLIHLERSNNYEKAAFYTLKYAKAQDLLGDITKSISYYKKVLKYPNVLNRSEIAINIAKL
YEKNSKHEKSYEYFEKANQFSIQDDEMQTEIYTLLELIIIQINNINDINTEVEYSLNCVR
RLLDRDFYPKGEVYYYYALALKNRLEYNHKLTLNCAEKALIICKENNIKEDIYGWVNTTL
ASAYIKEGDYQESKSLCLNAVEIFISNNNINGELYSRILYASICKEEGERNEIILEQYLD
LAKLSNKYKVYKKEILSLIYIANIYNQEKKYSLAEEYLLRALEREQEEGVDQYSFSICSG
LCLLYINLGRINLAVKYYYLMKQMQKGLKLLEEEVINTNYIYALYNLLVCNYDLAYDYLK
GIYALIFNAKNFNYKIIICNYYELMLHKCKNEDAIKNVYGKLDENIKKILNHDVELGIKI
NAIRRILLLGYKKFAEELFLNLNEYPRDYNMEGIYIYLELNFRGKNYYNFLINKALRICA
FINNQETKADIYAMIGTKYSELNCDALAMNYYYESIALHIDTVNSLPENDKLLYLNNSNF
IETRKLFIKCLNDDLAINMKFKLIESIKKYEEIDILLKELDLTNILGNKSIFKLAQNIYE
KCYYNDLSDIYKVFERFSTDVISDLENVIKYMARLTLADKAMIVIENNEGENDVICTYRI
SDKNEINRYFSLKVDSDEDVFVISNNDTRIYQLEDNILKYGMRSCMYMKIINRERYINST
SGINARLILITNNAMNYINQQSRKTIEQFRPFLIFLLEKYNLTISSTLDKLTGVYNRKYF
EESLLYMLDSARLEKSEFAVMMFDIDDFKGVNDRYGHQTGDEVLVKLTKEVKKCIGKRDV
VGRYGGEEFIVLLPDSNKEKALNMAEKIRKNVQEAKILGDKRNVTISMGIALSANESVNS
EEIIGRADQALYKAKYEGKNRCIVWENDYGISNYTNNELTGVLSGNATRDYNLAVILKEV
ANISKVKADKQEKIYQFILEVMKVIECETATVFILKDKKIINIYSKLRAKDGLHTGEKFN
FKLINQTIEEEKGMYLIDWESMDHYNQYGIPDWKSVCITPVICNGEVLAVFYLSVSVNKK
EFTCNDYNLLNCFADIGIPIFY
>A0A8I0SVP0|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MNDENFYKKAVDLDETSLLSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPLSREFTNLKTDAVLAGMWMGLMGVNALPSSA
LLMIICMNLMGAGGVRLFVAGLALMVVACLVTLQLTGASLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATKLALHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHRDATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRMTLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRVHEGLRGLRLACAPQVILHISVGVAPLTPQFGHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A1V5CRV3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin050|TrEMBL
MLRENEERLCRCFELELIGMAITSPTRGIIEVNDKICEILGYERQELLQKTWIEMTHPDD
LAAEIANSNRVMVGEIDGYSVEKRWVRKNGSVITSTISVKCLRQADGSVDSFVTLLEDIT
ERKHAEESLRQTLKNLTNERQRLYDVLEALPPMICLLTPDHYVEPVEKPRERL
>A0A1V4I6Y2|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MAFLSPVQVNIVLFILLLILFGHTYFNMNRKNITNRLFMWIMGLTAFAIMLEILSVLLNN
PNLKQFMVVQKMVNVLGFTVTPVIPFLGYIFSKEWVDRYQKEKIKLNKILLLPLFINGIM
AVISYSINVLFYVTSENIYERGPLFFILPCVSYFYFGYNIYFIYEQRKKFSWWELRIFNL
FYIAAGVFTGIQLVYSSYLTIWNGTAMMIVIIYIFILNDQVHRDRLTGLENYSSYEHYIE
NVSFKKIDKLFIINIDIDDFKNINDQYGHNEGDEALKMFANLLVESFPLRRKKLIRVGGD
EFLILLEGERQEIAENYIRNLNENIEAYNKTEEKPYEFKFSYGMACYSNANENIHDILKC
ADQLMYEQKKSRKVEFY
>A0A381G5Q4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MKLPHKALRLFISASVVVLTSSFLIYELIASYKSMNGYMRYIIEKADSSFLYDKYQNQSI
AAHLMRTLATPEKTLPADTRHTLCQSFESVNSVYGLNLTQHNYPALHGTLQTSIDDCAGI
ADDVLLLPAFDQAVKVNREQVDYGKGLATSEEKFHYYLDLQNQYIYFYDPINTRQFAMHH
WAFLQKGSLGIHQADIDELFSGRTVLSSIYQDDRTELNVMSFLTPVYLHGKLKGIVMVDI
NKHNLQNIVFTHDRPLVWRYLNASVTDTDSDKTIIIHQSENNLFPYVNYISDLPGGLHVE
LSLDILYFIVSSWKLFLFYLLATALLLNMVRLHFRLYHNVTRENISDAMTGLYNRKILTP
TLEQRLQRFVSTGTPVTFIAIDLDKLKMINDTQGHHEGDRAITLLANAIEASVRKSDYAI
RLGGDEFCIILVDAEPDMAARLPERIANHLRTVAPEKDIRFSSGSYSMQPNDSLHDAYTA
SDEQLYLNKHQNRQRS
>A0A379H5L9|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MTVGINYLTSDNKYLRVYLKNHNNAYSIQDDMTSLKVNGAQVKINDSSDLLLDLKDLNVM
TWWISGNKIPPYLSTAEINNIHYITIATGDSANVGEHRISIDSVYFSGEYIRKNDFLLIL
LITNLTSIISFLFLERRRIYFAQGKYLESIFLLEEERNNLNFKLIRDPLTHAFNRYAIES
LLIKYSERGPLEMPRLSIIYLDIDHFKVINDTFGHHVGDSILIEVVNLIQDSIGCDDVLV
RWGGRNL
>A0A5E4YPH2|diguanylate cyclase|EC 2.7.7.65|Pandoraea fibrosis|TrEMBL
MPDAMPAVPSQPSASPADANDVHDAHGAGGASDDALMFDLAPVSLWLEDFSGVRQLFDEW
RAQGVTDLRTHFRTDPAYVSACSQRIRVLKVNRRTLAMFNAPSLDTLVANLPRVFRDDML
KTHIEELCQLWDGKTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEATFERVLISLEDVTEL
EHARQRVTMGEAYARGLFEYSPVSLWVEDFSAIKRLLDDARSRGITDFRTFTDVHPEFVE
RCMNEIHVLDVNRHTLAMFVASDKSTLLSRLPDVFRDDMRHNFREQLIDLWDNKLFQQRE
VINYALDGNEINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEYLGKHDVLTKLR
NRSFYVDELNRLERKGPHPVTVIVADLNGLKLVNDQLGHAAGDGLLRRAGEVLGKAVVAP
QIAARIGGDEFALLLPSTDASGGAAVIESIRQLVELNNSFYPGTPLSFSMGMATCEAGER
LEATIQRADLLMYEEKRSHYAGSVNERRALDELPSGIGSEGGMGGRGSGA
>A0A837JYT7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MDKPLWLKKFRRLYNPGRVVNICFIVVLFFSTLLIWREIRVLEEAYVANQRNNLENVAHE
MDGLLQFNLNRLLFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTLTV
YGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNSNRIFSERMSYVSRSGFYTTT
DAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPLDY
EHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTLLSPKEQ
EKLRYALVNDNHGGIRQLTRYISWEKIRNFDGVLLHIHTLKEGVRGDFGTISIALTLMWL
MFTLMLIVSWLVIRRMVINMSVLQSSLEWQAWHDALTRLLNRGALFERAIAAARSCQRNN
QPLSVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREEDIAGRVGGEEFCIVLPN
TQLSQARAIAERIRLRIHSREILLHNSVSLRISASLGVSSSETSDEFNFEELQSIADHRL
YLAKQNGRNRVYSAE
>A0A8H9DF07|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGISTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNPRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHC
>A0A3S4HRA7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MTGSILLASVIALMLTHSLHRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQ
DFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPLTGLANRAAFRNVIGKLMDDDAARHSSAL
LFLDGDNFKLINDNWGHAAGDKVLIEVASRLMAFVGDQHQAWRLGGDEFAILLHDVHTET
EVQALCATLSEQFLQPFNLHNGHTATLSLSIGYALTWEHTSVEELQELADQNMYRMKNQR
FHHTQK
>A0A7Z8DLL7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
TDDTLGHAAGDLLLQRVAQRLLECVRASDTVARLGGDEFVVLVEGVHSTEQAGSTAEKIL
AAFGEAFDLGGHRRHILPSIGVSIYPDHSDEEHGLLVHADGAMYRAKKSGGNRICIASSP
>A0A1H8RBK2|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MSDSDIFDLSPIAMWIEDFSGVKAQFDRWRAEGVVDIRAYLGDDTTRVASCSRLIRVLRV
NRKTLELFEANDLDHLVANLGSVFRDEMLESHVNELAELWEGKTEFTSSAVNYTLSGRRL
DIQLRGSVLPGHEQSLAQVMLTTDDVTAREEARRKERENRRYAEGIFEHSPVSLWVEDFS
RIKLLLENVSDRGIDDFRVFTDVHPEFVRQCMSEIRVIDVNQATLDLFCAPDRHTLLQRI
GEVFRDDMEKHFREQLIELWNGRLFHQREVINYALDGSERYVLLQFSVLPGHEADWALVQ
VALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYADELNRLERKSLRPVSAVIIDLNGLK
EANDQLGHDAGDALLRRLGEVLNGAAAQPNHAARIGGDEFAVLMPGADKLAAVTMVETIG
ELLKINNQFYSNAPLSISLGVATSEPGETMESMVRRADIAMYTHKRAYHASRKPDEQGIA
ATNEKSASAA
>A0A381CCZ7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MSEEILRQQIQNLKRHNARLKRIAHDSRNKLSAALDGTGLCLWQLDIASGKLIIFNRRWG
SMLGYQPKELSAHFDVWREHLHPEDKEMVLSAFYNHLEGKTPFYEALHRMQAKNGTISWV
LDRGRVTEWSDDGKPLKVTGTHIDMTKEKQYEQQLATLANHDPLTGLANRYALHAQFDLL
KNLGSLSVAFIDLDDFKNVNDTLGHRSGDEVLLQLSQRLRDACPAEVTIGRIGGDEFILL
LPWTLDNQEIMRIALRCLDAAITPFELGNGAAKVGASIGVNESWASDNFSDAVIRADESM
YLIKRTGKNGVALGARILIQS
>A0A379LTN6|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MKFDKLRNDKSSIRNKLRKISTINAAVILLLCWLLLSSTSLLFIKNYEKRNLELIGATLS
TTLTAATVFSDSYDAHNKIARLGNEGMYASAKLVTKDQIVLVNWHAQQEQTGWYSRLLRE
WIYLKPLNVSIIHSDVAVGTLTLEGTVTGAVSFIRYSFMILTSGMLCVLIISLLLSEFLH
RGMLATLRNITSSIHYVIHSGDFSLRIPESTTSEFQLFSDDLNSLLREMQSLKASLIRDN
RSLAAKALEDPLTGLANRSAFAAHLSRLLDQQYAEERFALLFLDGDRFKSINDNWGHAAG
DEVLKAIAARLLSLASEQDLVARLGGDEFAMLVSSQVSEEQLQQLMQDIHDLIMEKIILA
EGTPINTSVTIGYAWSQHGDTVESILERADMNMYKNKRTNKA
>A0A2Z5SES0|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MPAEKEQTVVERVKNADYFFRSLVLVAALSIGAILMLCCYGTYKIYLNHTITTAEEDAVQ
VSEALLKHEEVNITKGDKEKGFTVTISPEELPHVDQRLRQFLRPFGIVKIKIYNEKRTIV
YSTDSAIIGKHDKNNVRLVRALLGFVDSKLEKSEDVLDMAEEKVIEVDVVETYVPIIADD
GRVIGAFEIYMDVSRYTSDVRNVVVSTFAILLVVLLSVFGCSFFVIRRMTERLREAEAEL
ERIAVTDPLTGIANRRQIIHRATEEFARQMRRKQQRTAVPSLGIIMADVDHFKQINDTYG
HSAGDDVLKEIASRIGSVLRQYDAVGRYGGEEFLVVLSETELEETWHIAERIRRRVADDP
VVVDNQAIRVSASLGIATVLAGEADYRPALERADKGLYLAKTAGRNRVMCAGDEQCRGER
FRPKLEAVKG
>A0A379AAS8|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MTAWGEWFSEQFSTGLMLLPFLLTRDWASLSPRQFMQMRKLAPVVAVIFFADDWRDDGPA
QAALTFPVPALVWCAIVLPMPLTSLVILLTGISEIILVSHGVMNIQGDDNMLPITHLTSA
RLGVATIAISPLIVAVSMDAIRQLNQRLALRANYDFLTRLLSRSGLYESLRAEPIFPDRR
VGVILLDVDYFKAINDNFGHDAGDSVLEEIARRMQRVVGKEGRICRFGGEEFAVVLFDQN
PEKLYFLAESIRQKMAKEKFWLQGSTATVTVSLGLAHGSAGEATEWHRVINRLISAADKN
LYLSKRNGRNQTSPVNYRAITSDVA
>A0A212JXA1|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfovibrio sp|TrEMBL
MMIKRTGRAPGMGIRAYIALGLTVMTLLFTASFFYFMSMAREVSVSGTRTYGLFMTLAEN
EKLTDSRNMARLRGAEAALAALPSLAVKQAEPEASAALAELSAAIAELATSQPVTDEMLL
QLRRTATLAHEFENRLLMGFLLLGAGLALLFGLLRLHLARPLQSIMVFLNQLGTGSPSQP
PKHSFITELHNISAALENLGTYLSLATVRSQKLASEHDHFQKMSLVDGLTGVGNRRAFDD
KLRSLWLHALQHGTPLALIMLDVDTFKRYNDSLGHQAGDECLRRIAAAMSRAARSTDVCA
RYGGEEFALLLPGADAATAQAVAARVHAEVAREQLPHPSSPVGDMVTVSLGVSSLTPLEE
QKEESQMLVRQTDSALYAAKAAGRNRTCVYGQAS
>A0A5E4RD69|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MSAPNTDKNDLESEYEALLSFMYLSPVGIVRSDKSGFVDMMNPLAAQLLMPLVRGGSIEN
IFDSLASVAPELRNLVASFEAERGPVCENHRVFVTPAKDDAVVLACSIIKVNADVLMMVL
TDISRQVAAERRARQTESWLAGIYTGVNDFAFFTLDAQGCIDSWNPSVERLTGFGEVEVI
GHMLSRFYANDEIVLHRLPEHIALTRDDGWHVEEFWCETKAGRRYWGQVLISVLREEDGE
ISGYSVVLRDITERKVHSDNLARLLTTDHLTGVTNRAHFFEIAESEVARAERHARALSLV
MLDADHFKRINDTAGHQAGDEVLRRIAGEAKALLRRSDIVARLGGEEFVLLLPSTSASEA
MVVAERLRVAVEQALIETAVGQLKATISLGVASLGDENQTLQDLLAAADHALYDAKQAGR
NCVRCAIAEPEDVSLSVSEEGNTVPT
>A0A011QNW4|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MRYEHTFAQSAEFLRQVVKRMGQQNAGLHPFSYAIWYEYVSGINRDLQIALDARIKSEGK
LDDAATCALYYKHVADLDAKTALRIGASVGHLVDQVADSATHAGDQASHYGESLERWGET
LQRPATAKGEPPPGLADILRGTREMQKAISDLHERLEESRREGQELRREVARAREEALVD
GLTGLANRKGFDLALSACLQKDAPAGPGPCLLMIDLDRFKRLNDAHGHLFGDRVLAGVGE
MLRANVKGKDTAARYGGEEFAVILPHTPRGGAVGLAEALRALVAASRIKNGSNNQTLIGN
ITVSIGIADYVAGESAADLIARADQALYAAKAQGRNRVNLAPRPQPEAVSK
>A0A1C3JD10|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MNKLSYDRKMPLYVVSALVLNMAFSLWLLSIASTSAMVFSVCALFLLSTLITARLYRHEM
AQSKNNLSEAIIDGVAGFIVLDSQLRVIQVNQQFSRVSGYAFDQVESRPISDLCFMNNSS
LIATITRSLKENQRWKGELSGVSRLGEQFTVNVVVEKLTEILPHNNKYVVTFTDISRRKI
LERRLRMLVETDSLTGCWNRRRFDNDLKHYSNLAERYGYTHSCLALIDLDHFKAINDNHG
HDQGDSALKEVAELLRNNSRDTDIVARVGGEEFAILMPETNLAEAFEAMYRLKEVITKGT
TLNLTVSSGVSEIQAQAEATYRSADKALYRAKGNGRNRVCSSSSGCATSIALG
>A0A556AS95|diguanylate cyclase|EC 2.7.7.65|Verticiella sediminum|TrEMBL
MREVSPSLLDTEGSAQYLDPEAWLGVYRRLDMPIRVRVATSVHEHARELATLFYTEMLAD
PQARPLLSPNVVSQRLHSSLMRWLRNLFEAEATPDVAGISHLQFTVGEVHARIGVPVPLV
LRGARILKAALADKLAQQPDLDRDELFRAQQFVGQLVDLAMEVMSSAYLTSTKRAARTDE
AYRLFSLGQDVSMERERQRAALMEWSQSVLLDLYYTDRRNVLPTLRTSEFGLWIYHKGRA
IFDGMPELAPLMRAVGEIDATVLPRLTAAVPQTGEERVGIEQLKQRVADIKFLLNALFDR
ISAVDAGRDPLTQLLNRRFLSSVLTREIALANRTHCPFAVMMVDIDHFKRINDRYGHDGG
DAILRQAADVLQTACRASDYIFRYGGEEFLLLLVDTDREGLAIAAERVRLSFVERVFRVK
EGMRLPITVSIGAALFDGHPDPQRLVTRADQALYSAKHAGRNRHVLDADDAPVDAH
>A0A124ZXV5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. TAD18|TrEMBL
MQTLMDNQRGKGLSFARRIYVPRTVGLGIGCFSVMAALYPRDMPLWIWGLLLFNGFVWPH
VALKISTRSAYPFQTERRNMLMDSLFGGFWAASFQFNPLPTVTILSMMTMNNVAAGGQKM
LLRGALAQIAGVLIAWTLLGIDFTPHTTPLQIYACLPMLALYPFAVGMVCYRLAIKLAEH
KRTLRALSRTDSLTGLLNHGSWKDLLQLSFHQCQQTGATATLALIDIDHFKRINDTYGHI
VGDSVLRKLSKQLKDNLRAEDLAGRYGGDEFCVIVPNRSLEQTQDIMERLRQVFSQVLDG
DEPGLQVSLSIGLASYRPDFDDASQWLNEADKALYIAKNTGRNKISVAAADLLPGSALSN
PG
>A0A149S4W1|diguanylate cyclase|EC 2.7.7.65|Gluconobacter japonicus|TrEMBL
MTVDTLPLNTSPLSPDEREWQLIIDAVDPRIRLIVAKTVEERAPEGVEFFYTTLLNHPEA
TSFLSNQIVNDRLHSALLKWCLSLFSALAPDLPSLIATQRRIGLVHARIRVPLHVVMHGA
RLLKSTLRQSLFESSLSPKDLSTAINYVENMMDLAIETMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREVQRAALLDWGHKILLSICCNAPPPLPLLESSGFGLWLNHKGSLLFPNTS
GIEHIRTAIRRIDHVLVPSLALETPPAATRIHELQAQIEEIRFLMDELFKESEALESGRD
PLTCTLNRRFLPTIMAREVAQSIRRQVPFSILMIDIDHFKAINDRYGHTGGDAVLRQVAE
KLVASCRTSDFIFRYGGEEFLVALVETDLRRAFQVAENIRESIAQVSTQPTGSMLSVTAS
IGVAHFEGHPDYTHLIEDADRALYYAKARGRNCTVIATPDLDSLPRY
>A0A5H5ILX9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ajiobo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDQLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A222NYJ3|diguanylate cyclase|EC 2.7.7.65|Legionella clemsonensis|TrEMBL
MDFPGVSKSQIEEKLIRESYKNFHFIILADFFAVILYTVFLWPYVSHPMMVISWMVLMIV
VNNASRFIMIFYYNRENKLPTLSHRAFWKNYFILNNLQSGILWALGGLLFLYVNDPLVRV
VIFVYLTGLLGAPAAKLLTYHRAYLSFMTPIWLVMLLLSISITASLSIILFLAVILYVSL
VIFATAGANKFLLKSIYLELYSSNLLLDLKRSEENFRNTIENAPIGMAIVSPEGTCIHAN
RTLQDILGYNDQELKDKNLLQITYHDDLIITKESMSKILKGEMRISHLEKRFIRKDGSII
WAMVSLSLIRDEQGEPINFILQMKDVSDRIQNEEKMRQLNEKTLETLNELKLLEHDESLL
NKLNRSLQICISAEEAYPRIHLVAQDLFPGLSGGLMVFNKTINQVETVLQWGEQRLLAKT
SLPLDCFVIREADIICVNNPQKSIPCNHYLRPPSGGYIGIPLIVQNDLIGVVHLFAPAGR
RLTQHQQDMAIAFGNIVKLALANINLRTSLNELSLHDPLTGLYNRRYLNDLLSRELIRLA
REKNTLCVAMLDIDNFKNFNDTYSHLAGDEVLKLLGQLLKKNFRDSDIAFRFGGEEFVVA
LLNTTLEPAAKKLNQFRELLKDTPITYKNQQLAKITISIGVAEAPKHGATIDDIIKAADQ
ALYAAKQAGKDRVKIYKNNG
>A0A8E5NCG3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Enteritidis str. 607307-2|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0J6WM42|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MPARAAAAGIAAATCLGLAVAPAPAPSLWYGMFTVCIMASAEIVGVLHATLYDAALRDPL
TGAWNRTGVERHAAELMARAARRSEPLAVIALDVDDFKGLNDRAGHAAGDRALAHLVRDW
GPRLPDQAVVGRLGGDEFVVVLTGHDASQAVHLARDLASAGPVNVSAGTAVGHPVDARSL
EALIARADRDLYRVKRERKAQSDGSAFGAQREE
>A0A8G1I468|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. ERGC3:05|TrEMBL
MENRLGKGLSFARRIYKPRIIGLGVGCISVVGALYPLAMPGWVWAFLLFNGFAWAHVAYQ
LSVHSPFPYQAEQRNLLYDSLFVGFWAAAAQFSPLTAVTIMSMMTMNNVAAGGKRLFLRG
LLAQAAGVGMAWGLFGIKFNPSVSLIQVYTCLPMLALYPVAIGMVCYQLAIKLSEHKRAL
SAQSRIDSLTGLLNHGSWKDLLNLKFHKCQQQHGQATIALIDIDHFKQINDTYGHIVGDA
VLRQLSQKLRLHLRQNDLAGRYGGDEFCVILPQMPLEEAAQVMEHIRELFSNYRNPQIPE
LRVSLSIGLADFRPVYSDAAMWLNAADRALYAAKDTGRNRVTVSDYVIAHSA
>A0A2Z3FCX6|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MPECLIPAKRPIPSALARGTLLPALLVIVAVAVGCALVSPPIGSWREILANPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEMVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDTWGHLVGDEVLFSLGKQLAKLTSEQVLPARIGGEEFAIIVDGLSEPELHDL
AQAILDNARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWA
>A0A1V5D3C3|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin153|TrEMBL
MEDSGLFALDTLKVAAAWIDRECIHKNANKRYCSALNRPLNEIVGQSLADIWGEETFDTF
LRPDLDRCLSGQQVSTETSLDFPVLGLRLCKILYHPYPDTAVDPTGAIIMIHDLIEPETD
KLNLQNSFEYLTEASREAIILVRDGLIAETGETFEHLFGQTGKDAKGKPIPDLIAPDHRA
QTMEQIRGRTGGICKTVGLRGESLRFPMEVNFRRVQLEGQELTVWAVRDLTKFEEIKYQV
EVYQKHLEQMLKAQTQKIERRESKYRSFYENAVEGMFRVNADGHLVSANTALAKMYGYDR
PEDLIQQASDLGDAYTRPKDGGRVSKLLHEEGVARDLETELYTKNGGRRWARMNVRAEKD
KDGCILYYEGIMEDITEKKRAEDRYRNIFLNATEGIFQITPEGRCFNANPALARIHGFSS
PEELMENATDISTQLHVDVETWHEYLALMEKNGYVRNHLWKMYRKDGSIAWLSCNARVVH
DETGQVMYHEGTIQDITDKQLMLDQILIQRDLALRLAQTGTVDAGLALVLETAVKASGME
SGGIWLKGPGEDMKLISSINFSPAFEKKCTYMPAGTRHWKRMMNKSRMVMVPARESMPNI
YEEGYKCAAVIPMLHDGRVIASFNLFSRTKDTISEEVLINLDFLAGQLGSIIVRMGIQQQ
LEQEIKTRREAEKALQAERQGLEEANIALKVLLGQREKDKEDLEQRFVSNVNELVLPYLE
KLRKGRLEVLQRSTLNLIETNLKEILSPFRHNIRNFNLTPRQMDIVTLIKQGKTTKEIAG
LLGTTKDAIDKQRFIIRKKLGVNKDKINLRSLLLSLQ
>A0A5Q9LEY2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFHQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDTRMQPWQLFSTRLGIAAMLISPVIVASSVEAINMLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRHLVGEQGMVARIGGEEFAVAAVVDSAQQGYVLAEKIRHGVESQPFGLGQNPI
HLTISMGLETREVGHARITELFNQLLLAADDEMVKAKQTGRNRICMPALTESAP
>A0A1V4X674|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin184|TrEMBL
MESGEDRFYPLSPGVPEDDPGSPGKGSLTGVSLVEPGSVSTSKDRTSAGRRRAGAMPRAD
WGFLDGAPAEPSDELKAFADNIPDGIFRLDRRLRHVLMNNAMAGLFRTSGERRPGSLDDW
DFVTTEAKGRVKKLARKAFTSLLPQELELVCEGQGGPLHFALRLVPEPGAAGDVGTVLGI
MRDITSLKRNEAEIQAEHSFREAIGRSLSIGIGAIDDQGRQIYVNPAFCRIVGWTREELL
GSCFPYVYWPENERRKARKIFLRVLRGGRTSGSFEVSLQRRDGTRFDALVMYSAFYDNSG
KRIGWIGSVGDVSGLKRKEKELQRLNRDLDAIVRKRTDSLRVQNRNLRDILMGLNKAQEE
LRLSETRVLLEKQRLETILNVVPAGVVVVEGREGRIVYANRRARDLFAGGTPSDWSS
>A0A1J5SJJ8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKFSDISLSARITFWALLLVVAGGLLWMNKDLENDREAYLSERSADLKMDMHLEQARLTQ
SIDSLRQDVLFLAALPSVSGIVRASSNNGIDPRDKSTYAEWEARLQDILAAFLRAHPEYC
QASYIGAAGEGRELVSVESRDGHVAVAPHDALKARGDRDYFKAGLMLTAGRVYLSEFAPD
AELEGKQGAPRLVLHAVTTVFDANGRVFGMVVIDKDVRSLFASVSEGLPPEVRSYVADQF
GHYLFRPDAGRETASEPGGKDSIAVDFPPLKPMLEPRIKHNESPSRTVSDGNGGYLAAER
VYFDASDPSRFLLLLCHLPANAATQGFRDISQPDLVGTALVMLLVGIVFMLVLRRTFAPL
NRITVAAREIAAGNRSIRLKEAGRDEIGKLSRALNTMLDKLSDSDQIRQESVFRKELIEA
LPGVFYMIDAQGRFLLWNHNLEQVLQLGPEEMAASHPLDFFSGPDKANIENTIRQVFAKG
DGEVEAELIAKDGTRMPYHLTGRRVEREGLPVLVGLGLDITQQRENLREAKALLRRNQTL
MRNSMEGIHVLDIDGNVLEANDAFCDMLGYTREEILQLNVHDWDVHFSAEELRARISSFI
GKSAMFETMHRRQDGTVIDVEICVNGVLIDDKAYLFASSRDITERKKLQAVQQRYKQVID
AAMDGYWMVNMEGILEEVNEAYANMSGYTMRELVGMHVTRLEANENEAEFREHVDKVMMQ
GYGRFETQHRRKDGRVIDVEVAVTFLPDAGKFFVFSHNITLRKQAEQALRVAAATFEMHE
AILITDAQASIVRVNSAFTDITGYSSEDVIGRNPRIMSSGRHDKAFYAALWKQILDIGSW
AGEIWDKRKNGEIYPKWMTITAVKNQRGETTQYVAIFSDITERKRAEEEIRNLAFYDALT
QLANRRLFIERFQTALAASVRYGGHGAILFVDLDRFKHLNDTLGHDYGDLLLIEVAARIK
SCVREVDTVARFGGDEFVVLLENIGGDGLEASHKAGGVAEKIREALSQPYHLNGQECLSS
PSIGISLYHGNEESMEVLISQADAAMYQAKEAGRNNVRFYDAQMQQNWESTRGSQPLMLP
D
>A0A1J5PZ38|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAGYGPYAGLPMTEAVIGVELLGMAMSAAILFAGALQSQRQEAMTTLRALNRDLESRAQE
RAQALFRKEHNFRDMIERLPAPIVMTSPDAAQVLYANPAARELFDHDQTDLADLSALAQW
LDPDMRQLLLGEVRQHHAAQNREIAFRRRDGTVVWVLASVIQTQFDEADALLFAFKDISE
RIQREVLLQAQALTDALTGVPNRRHFMAQAAARLRELVAQQKAAAWVLFDLDDFKLVNDT
RGHACGDQVLQQVASLLQAKVRSQDVFARLGGEEFCLLLTDLDANQALQRAEEMRLEIDG
QVTQCPDGQALPLPTSSIGVAWCPAAALQGVDDETRLAVLMDCADTALYAAKAQGKNRCV
LFDGPLPTTDASPAAPRHGVPRANAQALLPISLLRSLAREVHFGRFFERAAQAAAHLVGA
DGAAFIERDDDSLSYRFFHGLPDAYQQRFAAYRFPIEAGSAGQAIREGREIFQPDYASAP
QALPDFVDSGLKANYLVPVRAGSQTLAILALAWFSRHPTYAPDAQQAENVRLLADLMAGA
LRRERLERKLRQRATRDVLTQLPNRAALELHLSRAISRAGAERNSSLKISNDSGPR
>A0A1J5QHD6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKTSTYEADVFVQGLDMAIATHMDWTRRVLRCAVLRTSPGDDVLRPQAHAICRFGLWFTK
ERALFDLLDPEAAQRIDCAHRAMHEATRALCVRVLAGQPGQAADLDTFETAQGDLLNLLA
RVKTLVLTTIARRDPLTGLPMRFGIEHEFAHCRKEATRCGERLYVVMIDIDRFKWVNDTY
GHPVGDTALRQFAAALKSSVREDEPLYRFGGEEFLALLRCSTPDCQHKASERILDVIRSS
PVEVDPGLTLNLTATLGVASVGDQEDLASAIERADAALYEGKRAGRNRFVVAPDLFGMTG
>A0A1J5PAY5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAMQIAERMRAKVERQLFDIGDGKTVGITVSIGVATYLQHVDSPEEVVNAADLALYAAKQ
AGRNRVFRHETETSG
>A0A3P3ZN36|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSEQDANKERLELALEAAGLDLWENDLVTGEVICKTSKVFTELGYGEEESLSFMDDVFKI
VHPEDIPLIKTAINNHLRGIATQYRCEFRVLSKSGAWVWYANYGKIMDRDENNSGRRFIG
VTFNIDDRKRNEEMLACCSWAGMENIGGKLPRYHRSLRS
>A0A1J5PZ36|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPLFAWFLEIEKSVADMDVRRGCHVEFASSTRNRQIWRVSLVLSVMALISFVDLVHQSFG
DMPFYWVPIIIGAIYIRWRSTLLLSLAATGLSLATAWRWDTATTAPDYLERLVVGVMLSI
VAVVMAREIDRRERKFRAASFVDPLTQLPNRTLLYERLGSRLRQRNLTNPTVVVFIDLDS
FKHVNDTHGHGVGDEMLIEVANRLTHAVRAEDTVARLGGDEFVIMCTSITSVEGARVLSE
RIAAALRKPFRLNGLDVIGGGSVGCVVFDGGYIDPGELVKLADDALRETKTSEKGGFRLI
DRTASSTGTSI
>W6RSU0|diguanylate cyclase|EC 2.7.7.65|Rhizobium favelukesii|TrEMBL
MTARILVVDDIPANVKLLEARLVAEYFDVLTAGDGYQALAICERNQVDLVLLDIMMPGMD
GFEVCERLKANPKTSHIPVVMVTALDQPTDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRAETAQTMGIDELLRSGEGRGDESGQVLLVDGRANSQERIIKALKPVAD
VSAISDPQAALFEASENPFELVIVNANFEDYDPLRLCSQLRSLERTRFLPILIITEQGDD
DMAIRALELGVNDYIVRPVDPNELVARSLTQMRRKRYNDRLRASLKQTIELAVTDPLTGL
SNRRYLDNHLSTLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDAGDDVLREFASRIRST
VRGADLACRYGGEEFVVIMPDTSPEVAAAVAERLRSAVETVPFLLKSSGQELSVTASFGI
SSRISSIITPGQLMKQADLALYEAKTGGRNRVVAAA
>A0A1J5T8F8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSDANHPDWHTGFFRDVLELADMAVMVINHNLEVVYANEYVCSRIIGMPQSVVVGMALPR
HKTVPDEELQKVVDHTMRVLEQGVSERIENWALHRDGTRRLMYWSTVPKFDADGKVEHLL
AVGMDVTEQRKEKHLLENIAHRDALTDLHNRTFFERCLPEDVMRANREGTGLALFYIDLD
GFKQVNDRHGHEMGDAVLREVSARLRKSLRQNDIVCRIGGDEFAVILPALSSGDDAGTLA
EQIIVSLSQPYSIDGNKLSLGASIGIAFLSKDVPGPQELLRKADAAMYQAKQAGKGRFMI
SGSGS
>A0A1E3KXY6|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MVLELINNLTLTSTFLFLGNLLLNKVRDELIKRKWFFISLAGIVYGLFGLVLILWGFHLP
ESDVLIDLRALAVIGAVYTVGRLSGLIAGTIIIFGRLFLFEYGDMDVLIVSIAIVLGAWI
CSSLLLIGEHRVLLSRWLITICCSMILPPVLFYLTLENPMLWQFLIILSVFLVGGLFTYI
ILVYLTRSNHLFLLLKELANRDHLTGLHNPRAFEALFEETMNYAKANQKSFSLLMIDIDY
FKSINDTYGHSSGDAVLSQMGELLQEFVRSGDTCARKGGEEFIVILNYCTQDNASHVAEK
LRNVIEHNTFLLPDQRTLSITVSIGVATFPDIKPNVMLAKVDEALYEAKRQGRNRVCAV
>A0A1C6L0Z7|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MYLGNLKIKIFSQNLDLETLLRRADLPEHLNCQIETYTEAREGIHSAGDIVFLDNPSAGQ
IPAFKDGSYIQFILVACADLDQIETLGNELLGADEVWEKPYNDRLLTLRFLKLLEMAQSR
KNSRIQELCLDTLLECMPDMVWFKDVKGSHVKVNSVFCQTVGKPKEVVTGKDHCFIWDIS
KEEFEKGQFVCKETDEFVMTKRQKCFSTEKVSSQHGMRQFNTYKAPVIDDQGNLLGTVGI
GHDITALENMSAELELILRSMPFAILVWNEEGTIINSNEKFEEYFGISKSEIIGQKSTAW
SKEILKDFKEMNDVGYTEAKVYYDAPDMGPRILEINEVPIHDVFHNEAGRLCIYRDITKE
RELEEKIIKSSNSDFLTGLNNRRSFYQYIRENRRFQELGLLYVDLDRFKYINDTYGHKVG
DEALVITAELLKECFPKDFIARIGGDEFLITKLGAFTETKLAEEASHFLDRMGQTFSNSV
CFQMLSASIGISSTKGADLDIDELIRQSDAALYEAKQAGRARYCFYSKHSCDK
>A0A3Y3SY20|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C6FMB4|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKAIMKYELIINEALRSALDNDIPDDEINEFIRFFGKHTNSDRIYIFEDDMRNHITKNTY
EWCAEGIVPQIDELQNVDMEVIDWWYDTFKDGKSVIISNLEEIKETHRLSYNILSKQNIH
NLVVTPLYYKGEISGFFGVDNPAETDYETLTVFLDMIGMILISLMKIRNSFRKSNYEAKI
NSYSSLAAIYASMHLIDLKTETFQIIKNTENIARNCDNIEKDNFPRQIRNVMIKLCTEKY
YDNVMHFTNIRTLEDRMKNVSTIADEFLGTVHGWCRERFIKVDNDENGNLWHVLYCVEVI
DEEKRRENRLIYLSETDLMTGISNRGSGEKKISELLRKRVGGMLVLIDCDKFKSINDTFG
HNVGDAVIIAIADALQRLCGENDVVMRLGGDEFAMFIPKIVDEASANDFFERIFDSIDEI
EISEMGDRKIYVSLGASICLAGKETTFDQLYREMDIAMYESKKQDGYCATLYNN
>A0A701W614|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:a:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRTCASDATQEREKK
>A0A1C6L7M5|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNDFPNEKIPQRTDPTFEKGWTYQIGARQGTVDSFPLVEKGKADRLILTVKLPHLDGSEY
LSFANQYAGCQVFVDGVKIFDYGEETTAPFGSMLGNLSCNVPLKGQYSGKTLSIHLEKKY
DFTSFKVEEILLGSGSEIRFYYAKTNVGVLACTLLMSLLSLAMFVLYLVQKSKKFKYDYK
LFLHLGFVSLIGAIWIFTDSLLPQFLFGNTIIITVLSFWAFMAMPIPVIHLVDDLCRYGK
KGLHTAEMAIFLNMIGQTLLYMLNLADFPQMLLATHAILVFTLGCIVYALLKDSRSSEAR
FANDILFAILVLILFGLVALTDFYVSGSSNNNSLYYRWGIVIFVLLLIVANIKRMGAFLE
EWEQNRVLSKLAFMDIMTKTGNRSAYERFLDDKADLDVKGGNLSLVLLDLNDLKKINDTY
GHNAGDQVLVEAARCIKTIFQNVGDVYRIGGDEFLVIIEGSDVDGQHYQEKLSAEIEKNN
QKTKYPFTLAFGFASARGDDCSDLKELQKKADLNMYQDKQKYKK
>A0A7I6Q7G1|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP3-W18-ESBL-02|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLLDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEASQIDTLRTAERIRSRVEKTKIAAPDGNDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A6L7EJA9|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. Lac1|TrEMBL
MNKDFSQAPRPTFKRALRRISVISVVISMTLVWLLLSTASVFTLKQYAQKNQALTAATMS
RSLEAALVFADSAAAEETLATLGKQGQFSEALVLDSQQNHFAVWRNTDLVRQEKLSGIIS
QWLFPEPTTQPIWHQGKVIGELRLTALDSLISHFLGISIIVLTGSILLASFIALLLTHSL
HHGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRTSLHDPLTGLANRAAFRNVISTLMKDETARRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMSFASKRHQAWRLGGDEFAILLRDVHSEAEVKALCVSLSGQFLKPFNL
HNGHTTTLSLSIGYALAWEHACAENLQEFADQNMYRMKHRRLAQGQK
>A0A1E3ATU2|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKFRHKALTIKKEIFLMSFAFLATVSLVFSGVFLHILYKKNMENAGNSLRECNAQIVIYT
EGMFHENESIVNILSRADTIVNGGSGNPAAVLKIYDAILKDNSNITYIYSGYADGRLYIN
NYDIPDNYDPTDRPWYQAAVASDGVARLVYEDAANGEWLFSQSKKLVDDEGNVVGAVSVD
CSNELISRQLSTRYQYASQRSFITDLSGKVLIHPDERYINDTILNYMEKDSWDKIIAGKV
SYGEYQKNGIKAMAYFEQFPGTDFIVCTAIDAREVTQPIVWNMVHLLFMLAGLSLLFGFL
LSRVLLYRFGGPILELKRRIENVVRGCPEEYREAGFYNAELNGIADSITIIVKNIAKKEE
QRKEAEYTSFHDSMTGLYNRRFFSEELRRLDVKRNYPLCIICCDVNGLKLVNDVFGHDVG
DQLICRVAESLAGVCRADDILARVGGDEFALLLSHTSEEDAEGIIARIREGFPAENIRGA
QISASFGYGVKKKKEDSIAVILRSADQMMYRRKLTESEEMKQQTVANIIEASAKEGLVTE
LTEKEEHALEQLSAALCPGDEALLKQAYRLRKIGLCSLFQSNMKNEEEIMLSGINRRHTD
NSYRILSASGEYRGAAGYVLHYTEHWDGSGWPAGLAGRDIPLLSRVIAAVDAFVSENSDG
FRLKQNDGWYDPEITALLQNLSEDGIQQESAPGVS
>A0A212LLU1|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MAEELRILLIDDDEVDRMMVKRALRAAHTQIIIHEAVTGSQGLNEAQTGRYDCVFLDQCL
PGDSGLAVLSAIRAAGVKTPVIILTGQGDEQLAVDVMKAGATDYLVKNKLTADSLSQCLR
AAIRLGRAEAMIEYLSYYDAATGLPNRLLLIDRLVMALAGIERSGGMLALLFVGVDRFKL
VNDTLGHGLGDKLIHLVANRLNACVGKQAVVSRVGGDVFGILLPELADSQVAASIAEDLI
EGIRQPVDLNGYVWHTSASIGIAVCPDDGQNVDVLLKNAESSMYRAKEQGGDAYQFYTKS
MNERVLERMLLENSLRQAIDNNELVIHYQPLIDGTTGRTVGVEALVRWLHPERGLIQPME
FIPLAEETGLIVPIGEWVLRTACAQNKAWQDTGYPPVVVAVNLSGRQFRQPDFTGRISKV
LAATGLAPEYLELEITESIALEDVEYTIAILNELGAMGIGIAIDDFGTGYSSLSYLKRFP
ITTLKIDRIFVQDAAKSQQDAAIISAIILLAHNLNLKVVAEGVETPEQRLLLRERHCNMM
QGFLFSRPLPAEQVASLFDFCW
>A0A212LRR6|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MGLPAFDVLGFLLELFKGFCVLYTVTNLAAQHYRTKLLVLLHESSGPNHVGIMFFLVLSG
LAMIFPIQLPYLDVFFFDLRLSVIILSTLYIGVADSFIVATATLVFRMLKGGLDWIWWAA
GIYVYVASAYLIIKNIRSRNLGLFAASVVITALHLGLLAVLSAYHPGFNFVSPFVAADNF
LLLAMTLLMSIPLSVHMLDLSLSRILAFQNQYSELQYKADTDGLTGLLNRRRFQELFSQL
PALYPGKPLSVLMIDVDEFKKYNDTFGHPQGDVVLRRLAALLANNVRESDIVTRYGGEEF
IIGLPNTAAQEAVRIAETIRGAIENTPFYGRQITVSIGIMSCTTSDISMETMIAGADTQL
YRAKKAGRNQVCLEFVI
>A0A8B4S7L8|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MASLAYLLVITSRRAVCMHTSNDHIFVLMPSLSLLFLAGLLGVCWATQPKQRFLLWLCAA
FLLTAMSISIRSVLKFEVLNHYVVLVNALFLAGAWCFSKSFSERRRVPTYPLAALVLCAA
TLASLYYFANVAQNQAGRLHTFGIGVALILLLPVPAVLKRGLTNDWLDRTLLWSYLSYAV
FTMLRPTLVAAFAHNGLGDAMDANSTYWLTTLMSILLFALLFTVLVCAVTIRDTVRQLRT
ERDLDALTQILNRRAFREAAQHRLSDQRLYPMALLASDIDHFKRINDNWGHDKGDQVLQL
VARAMQHNVRSNDLVARFGGEEFMVLLTKIDLQGAEQVAKRIGLELRNDQEVLPNGPALT
LSFGITSISNADQLEGALRQADQLLYSAKNAGRDRIHVEGRTYPDISFEHTIPTDHPMAL
LM
>A0A8B4S0C8|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MFANNDLILVLTPSLAIMALAAILIVAWLVQRPQRFLLWQACAYSLTAPALGAQTLLSPQ
ELNRYALLIGSCYLLSAWCLAKSWAQRWCVSTQPRVALLIAIATLAALYQFSQVEPNVWA
RVSSFSVGSSLVLLLPILQVHSKKNSYDWLDKSLLWLSISFTAYTFTRPALIWLLGYTDL
RALPRSPYWILTLLSILNFSLLFTVVMSAIAVKETVGKLRKERDIDALTQILNRRSFQEH
AQKRLTDMRRYPMAVLACDIDHFKRINDAWGHERGDMVLQLVSSTLQNNVREHDLVARFG
GEEFVLLLADITLGDAELIAQRIQRDLGSKNTVLPTGPKLTMSFGISLITKPFQFEQAMK
EADQLLYQAKNAGRDRVHVSGVFYPDISVETHRLWSRPAA
>A0A8B4RYL2|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MPLHRDIHRRTYPLRASYMALGGAVVAASLSYLPTNLAWWAFTAVSALLWPHIAFLHSSR
QQDQFHAEYFNSLIDALIVGCWISLMHWSLLPSICILAIGVADRFYTGLKRRWLPSLIAL
LCGMLFMSIAITPTPQWDAPLAVQLSLLPLIILHSAYASWSNSRMLKTLARQNLQLKLLG
RIDPLTTVYSRDYWWKKARAALHQHRTVKEQTCLLVIDIDRFKSVNDLYGHIVGDEVLKM
IGLAIRNSLRSNDIAGRYGGDEFTVLCKHTTAKEAYSVAMRICEKIAQIRIREYPQLHIS
ASIGVAAADDSFGSVTEWIKAADSALYSAKSGGRDQVMDATQQPERQHSPSTMPMRPEST
RISPASSGQESLDRDVV
>A0A0C7NRP4|diguanylate cyclase|EC 2.7.7.65|Defluviitoga tunisiensis|TrEMBL
MTNEIPTKYIKKIRRAYINPGLTYVLNRFCDLFLFSINVYVDINEDPEKVPSNLYKFLKI
CNSFKLFKIMSFQEIKDISQQRIMLDMPGEAGKVILTYEILIKDEVYLVYEIIKRSKPIV
SVILTDILLNSAKLGSVFKTSKIILERSYDIESSVDEMIYASMTGITGGFAGAFNRAILF
KEDGNDFRVHRALGPADESEAHMVYDAFETLEMDILPYLQGYTNNMEYFSNLEKNIKSIS
IRKRVLFKNQLLNKAFEKNATIKSPVSNLDESLVHALGLRGEIAFSPLKISQENIAFYLC
DNRYDGKPITDEQLEILDYFAKQSAIMWQNKISLNLLKEEAEIDMLTKVGNRRGYEKYIS
SLSYQKSQSIAIAILDLDNFKDVNDKHGHQKGDEILVTFANIAKKNLRKTDKIFRYGGDE
FVVILHDVSQTNVVNVIKRLQKQFFAATNCTFSAGVSYGESSNISQLFDDADKKLYEVKQ
KGKSDLIF
>A0A7W6Z4J9|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia fungorum|TrEMBL
MDTSKPYQNATAPDAAEHDANAQAYAMDAPNSAIDDALARILDSPSAAECPIMVLLVDDQ
AIIAEAVRQALADEGSVDFHYCASPEDALRCAEETRATVILQDLVMPGTDGLTLVRQYRQ
NPATRDIPIIVLSTKEEPLVKSAAFAAGANDYLVKFPDRIELIARIRYHSRSYLNLLQRD
EAYRALRQSQQQLLATNLELQRLTHSDGLTGLSNRRYLDEYLTAEWRRGTRDKTGLGFLM
IDVDNFKAYNDTYGHVAGDEVLKRVAQTIESCLGRAPDLAARFGGEEFAVVLPGASSGGL
RLLAEKIRLAIEGLGIAHAGSASGVVTISVGAAAIVPSAAEPVTTLIEAADVGLYRAKRD
GKNQVAVTR
>A0A1Y5ZHA4|diguanylate cyclase|EC 2.7.7.65|Bacillus cereus|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEEFSFWQKCVVGIFTGILSVLLMYFGVHIEN
IMLDLRYLAVILAIIIGGPIASSITVTIILITRLFLTEYSLASELACYTIVLIGVGIIFI
WRMKASIFIRWIWFNVYSLSILIVPLSMLFKDMSIVALYLVCSSVAAYITFISANYVLQS
NELFQKMKQYATIDALTGLGNVRQFDLEMNHHIGNKRMKNDSLCLLLIDIDHFKSTYGHP
AGDEVLKQIGRILREVSTFPDLAFRKGGEEFALLIPQKGLAYGMRMGEQVRAAVEKHSFQ
LLDGTKIKITVSVGISVYEQSPEQFIQAADDALYYSKRNGRNQVSSAS
>A0A3Z3KCE1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Adelaide|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0T9NEC1|diguanylate cyclase|EC 2.7.7.65|Yersinia pekkanenii|TrEMBL
MDLSAAEKPAPDNKTILHITIISIVVFLLALFCIQLSEQSENLAPLWFPTAVLMIALFHH
PLRYWPWQLLTAGICIVAANFILYGISWFPLPLTLINLAEAAVGAWLLRKFLQPKDPLNS
LFSWLKFSICTVVIVPLVSGLAAAWYLSPQNDNFSQVFTIWFMSEAIGMLALGPVGLLYR
RGYFNIATQSNALFDMMWMTVLSLAACYIGLLYLPFPFTFVIMALIWTSIRLPRFETFTV
CFLATVLIAMMINFNLFTLQADTKLSVQAFSFIPLLMVLIPPHAMSMVMHAFRMEKANIV
ESENRFRNAMEYSAIGMALVSPEGKWMQVNKALCKLLGYSQETLLTLTFQQITHPEDLSA
DLKLLDDLYHGRIPSYSMEKRYIRSDGEVVWALLVVSVVRDHELQPLYFISQVEDINELK
KTEMINRRLTEALHEEKERLHITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTSALG
QPVNQIIKLTNGVDGPEIDNPIEHCLNHRAYSSLNESMVLHHRDGRYYDIQESVAPLKTL
EGDIVGAVLVFQDAGESRAMMRKLSHSASHDNLTGLPNRANFDNRLKAAIQISVDLNQQN
ALAFLDLDYFKAINDTAGHPAGDALLKEIGQLMHQHLRNSDCIARLGGDEFGLLMLNCTL
PDAKAITQSLVSMINGYHFHWEDKLYRIGASAGVTRISSSNNQRSEIMAQADIACYTAKR
SGRGQVRLYQSQQKQLPVLLPRSR
>A0A7H4SJN1|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTLPVFGVSGSVVGNNPILLKDD
PLAADELMATLELGYLLNLTQHDRDFGRADASISLAAAFFTSTLPLRDESQVMTHYSQAI
SALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEI
KAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPREQELLSRAFVHDNLGGLRL
LTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMV
RNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQRSGRPLSVIQLDLDHFKRIN
DRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVLPNTTLQDAVAVAERLRLRI
QGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADRRLYLAKQNGRNQVCFRQRS
VSKTFRPNQAK
>A0A7H4MCL0|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MQNGKDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRA
IKHVADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLPQKDWPAGV
>A0A7H4SEQ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MAEALGLALANQRLRSALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMID
IDHFKAINDRYGHEAGDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQC
ASEIYTQVHNMTLRDGLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRI
VSFGRLKTR
>V0YU45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 908573|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6N2TV13|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MNQLIRKYIMVLAAIFCLILTCSSVSYAEEAESVIRVGFPMQPGLTMKDENGNYTGYTYD
YLKEIGQYTGWTYEFVEPQDSGTIDEQLIQMMDMLEQGELDLIGAMNNNNQTSSVYDFPS
ENYGNAYSVIAVRDDDDRIDEYNLSDFKGLRIALLKQADYHNEKFYQYAKLNGIRYEIVW
CERGGEQEEKIYSGKADAMLSVDLSLPQGFRPVAKFSPIPFYFATTKGNTQIINELNRAI
SYTSENNPTLQMNLYNKYFSRSSSQLFLNSKEREYIQEHPVLKVLVHDGFGPIQYYDGKG
QVQGVARDLLSSIAQKAGWTLDFVYADDYSEFEQALNEGRADVILSILYDYDTVQKKNVL
LSNPYLETESVLVAHDGVDMTNLKGKIQAVYMGMRKTDDEQADVRFYDSLEESLNAVEKG
ECDYTYSNSYTASYYLSRNRYEHVSIYPQAGSDSVKYSIGILRKDDKQILAILNKGIRSI
ETGELEKYIYNNAQQKQKVTLGTFIRDNSVPFILFTLLAASGLLALIYIHYRSQMRMKRQ
IELENTRYRYLSDILKEVTFTYDYGSDVLTLSREGVELFGADESIGQYSRYQGNGKQENG
LPSLYYLLEQRQDVDAEILMALPDGDAEWYRVVIKVIFDGSQADSAIGRLQNIHGEKLER
ERLEQRSKRDGLTGIYNIAAAKMEITRMLDRHTGSLALAVIDLDGFKEINDRYGHYTGDQ
VLIYTAKALRESFCEEAVTARLGGDEFIVCVPYTGQNHLAECCNAVFDSLQAGCRASGYP
AATVSIGISISRREDDYTTLYQRADTLLYEVKNTVRIISG
>A0A0J8D940|diguanylate cyclase|EC 2.7.7.65|Clostridium cylindrosporum DSM 605|TrEMBL
MNIVEEVKNRLSVFKNLYDIFRLVDPVNKKTITVNDNSIEESKGYCYDFWKRDEFCKNCI
SIRAYLEDDTFVKIQNNEGKIFLVTATPLILNNNRYIVEILKDITQNGKIQTKNDSSENY
TEYVLNELNEKIIKDELTGVYNRRYINETLPVNINKSIVKQYPLSVIMADIDFFKKINDN
YGHLIGDKILIDFCKLVKYHIRKSTDWLSRYGGEEFLIVLQDTDLHSAYKVAEDIRKSLE
NTVFQYDDIKIKITASLGVHQLSSHKNNMDELLLGADRNLYHAKITGRNKTVMEL
>Q3Z526|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSG
>A0A822V421|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. B6|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADTDGQVNGILTDKPIGDDDSILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLSASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQSTNGDCES
DAAMLAARVVHAVSRNFNLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEAGMDMAAQHKHALEIDMKSALENHEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLITPDRFITLAEENNFIRPLGEWVLAQACMDAMTWPKDIRLAVNLSAVQLCNDDIV
PVVDRALETSGFPAERLELEVTETAMLERDSSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPANPMCSAIVNTVIDMAEQIGLKVTAEGVENSEQVEALKLS
GCDEAQGYYFAEPVPLARILKNRAVITPIAQGEFGDIGRPTQETYCPPQKAI
>A0A4U9H9B2|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MMGLFRRKRAAHARPTLGQVLQRMNLSLALIAVGTAGVFLTLVALFALRAYANHNLHLIA
RSISYTVEAAVVFDDRSAAREALMLIASNEEVSEAKILNKDGRLLAYWHHPKDGPLHGLE
QMVARWAMPEAIELPITHEGKQVGKVWLSGHGGSLLRFLLRGLAGIIACLALSTLCALIL
SRRMLHGIVRSLNDIANVAHVVRSDRSFGQRVPSAPIAELHELSNDFNGLLEELETWQAH
LKQENDSLTHRATHDSLTGLPNRAFFESRLSHALNHIAPAEKLAVLFIDGDRFKEVNDSH
GHAAGDAVLTAIAGRIRAQLRDGDVVARLGGDEFAVLLSPVRRQADVTRIADKIIGSMAQ
PVPLPNQEQVIASLSIGIAFYPDHAATPQGLLHEADDAMYQAKHRYHGGWRLATQK
>A0A142X571|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL14|TrEMBL
MKTQSRTFRLPTFPAVAVRLLDVFSDPDVSIRDVAKVLESDPALAAKILKAANSATFGCG
RGIADIGRALTLLGKRTVTSLALGFSLSDVATKRGDQKQLFQDYWLQAVVRATTCEHLGR
RYSRGKEGELFAAGLLSSLGWLALLHSEPAKFDEIRKKADVEDLNALELEQEAFGTDYIQ
LTSQLLGQWNLPAELISAARDQAAELTVLEGTDPSEITIFDKAVSVAAAMGSFLCQGKRA
ISLIRIHELMGMFFGASQDDVDQLIAQVRERLSASAEMFQAEAGHLPSPSEILSQAMEQL
SELAASALRDGNTPNSQDVLEENGRLRRRVEELTRRSTIDPLTHIFNRGYLTERLAEQVA
VARLRQQKVGLIFIDVDHFKSVNDTYGHAAGDRVLERVARAIESVIRTSDVLGRYGGEEF
IVLTGSGDITGLGCVGERIRARIAEEAIEYDGRPIVVTASIGGALMGPPIEGDDTQQRLI
DSADAAMYMAKRNGRNQVVLMHENEQGQQETVMAQD
>F5NUG0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGHLGGDEFLVVSLNNEN
ADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKK
HKQKTPFVAHPALHS
>A0A4P8BZH0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:NM|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
RWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSADARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDL
HNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A143QKM7|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MADQRTYPVGQLARAIDQLPSMIGYWDSAERNVFANKVYADYFGIEPARLVGMHISELLG
EGLYELNKPYISGALAGEQQQFDRTLIDVNGVVRVTQATYVPDVVDGGVVGFTAMVVDVS
ARAEAERERDRAVRLFQIAMEYAPIGKALLTIDGRWLQVNKALCDLLGYTSEELLQKTFR
DLTHPDDIAMADEHLAELAGGTLTSVASEKRYIRKDGATIWVQRNATVVRDNDGDDIIIA
QIQDITARKGAEAALERQLLIDDLTGLANRRRLMAELQALKEAADENPVGILFVDVDSFK
SVNDRYGHAVGDRLLAAIGARIRANLRAGDIACRTGGDEFVALLRSSRSADGVERLAARV
RVLLAGPYLIDGVPVPASVSVGWSWDKPVSPEKLLHIADERMYSSKRR
>A0A377GF16|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MDENLKASRSLLSYKDSILSKYLLYLISIPAFIIVLLVSVYAYKQVRELVDANNWVIHSY
QVIQATDKILYGVIDTESHQRGYLISGDPQFLESIQFHTKDINQTFDTLLQLTKDNPLQS
ERITRFIDLVNNRLQIIQQVIKVKMRTKLNSPETMVLFHKGQDVSNELKALGNEIQAIEL
VILKERNLMVINSAHKTNLIIIIGSIVSLSGLILAFLIGNYELSRSRKAEQHRLSTEIQL
KSILESASDMIAAVNSDRQFIIFNEAYHREFRRIFTKSVSIGMPLEDASSHVNDSNRDLW
DLWEKSLSGEEFVKSIELEVNKERHIYEITSSLIINGTNQIKGAVHIIRNTTKMVEEQDK
LKEMNRNLNLGLQALKDKNEQITLLVELSDILLACGTQEELHKVVTQYCQRALNFTDGFL
YVMHPSKNYFERVASWGNPTSQEISFPPEHCWAIRLGHIHTVSPAHNDLICEHVKIAAGK
QIWSHCVPLMAQNDIFGLLYLEIKEDKAVLYSNDHMLLITAFSELTALAYANVRLRENLR
YQSIRDPLTGLYNRRYLEDFLFKQIHQAERAKLPIAVLMLDLDHFKRINDTFGHDAGDII
LKEVGKILQDDIRVEDMASRYGGEEFVIVLFNADAKSIKPRAEKIRRAISMLKVKYGTQY
VGPITISIGISSFPEHGRTLVELIEAADKALYFAKNNGRNQVILYSDFMAKKEEVNVKND
KEK
>A0A8B3WB22|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MSIQLDLTTTTPCQNFDSAQGRMTLQNHRIIDVDNEIAQIFGYRTREKLLLNVEFVYALV
PDSYQELAKKRYLESIKGKLKKGKLYTDIPVNGRNISIFCLSHIIELNSKPALQVTIIDI
TSVVEAQRKRNETDRMYRKLLNTSKQGILIHRNFKPLMVNQAWVEQQGADSIEQVLTMDS
ILSIVPEDQRSTAIRRCENILNGNTPNFSSVVSNQCFDGTHKYFNLYDNVINWEGEDAIQ
VILEEVTDKVLLERELLHRAMHDDLTRVFNRRAIYDWLKKPVNQHMEMSCLLIDIDDFKS
INDRFGHTVGDTVIRHLADTIKAHIELLGGVVGRWGGEEFIVFIPKAKSAHTKIISERIC
HTFNQHTFYGINRRAFTTSVSIGVTNQCLCHSANTIDTLIRVTDDALYRAKANGKNQVSI
NDDVVCYEALA
>A0A7U7GBG7|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MNTERDRDWALLRERAEALLDDSRLGVSTLSTIEIERLIHDLSVHQIELELQNEELRTTQ
NQLEQTRDRYARLYHQAPVGYLTLDASGIIRQTNQTFASMVGRGRGELAGRALADFLADP
EHDVFLGRFSAFFKNPEGKSIDVTLCNKDTHKFAARLTGRKDADALLLPRRELVPSMTLL
LVIVQDISQQKAMEDALRASEERFRGYYELGLIGMGIMALNKSWVQFNDRLCEILGHPRA
ELATTTWAEITHPDDLAAEIAQFNRVLAGKTDGYTLDKRFIRRDSQTVHTIISVRCVHSP
SGSPDYLVVIVQDITERKALELELRRLATTDPLTDLANRRHFLAQVELELELLQRYAKPA
ALLMIDLDHFKQVNDSYGHAAGDAVLRHFATVARHVLRKVDLLGRLGGEEFAALLPGTDP
EGARQLAERLRQIIASSPAHTASGIITITVSIGVTLFALSDSAADTVLARADRALYRAKD
EGRNRVEVDIPELPLLPL
>A0A7U7J523|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MKLPIGKIQLRILGILLLIIAIFIVALIRNAALLTFILSGLLALVTLFVALLRWINRPLR
LLARSLRSHDPALLDSLSDRDTEFGQLAQLVRDFFQQQQRLTVEITERRQVEHQLRLFSR
AIENSANQVIITNCAGAIEYVNPQFVQVTGYSAAEVIGANPRILKSGKTPPEQYQRLWRT
LVSGQEWRGEFRNRRKDGTLYWESASIAPIRNEKGTITHFIAIKEDITRRKKMEAALRAS
EVKYRGVFATIGDSLLLVDGRDGRIFDVNPAACKLYGYSREELLALRDRDLAVDAATHVE
LLSTPSTRRVDHLHRRKDGTVFHADIYLRRFTYQGHKVTVEAVRDMTPQKQAEQKILRLS
HCYAALSRISAAIIRHAEPHDLFQQVCQIVADLEQMQIATIGFVDSETGGFQPAAHAGAV
PDYPRYLASTHLFDDPSIPEIWEPTGMAFRQGSPVVNNDFPSDPNAQGWRQVAGVMGIHA
GAAFPLRRNGRVVGCLSAYAAERNFFEADITDLLNNLAGEISFALDLFDREAQRKSAEAR
IHQMATHDPLTGLPNRTLLLDRLAQALHHAQRKRQHVGVLFLDLDHFKTINDSLGHEVGD
QLLQQVTERLRHCIRQEDTLARQGGDEFILVLPDIIDPAAVGQVADHLLHALHEPFMLND
QRLHIGASIGVSIYPLDATDPPTLIRFADSAMYQAKEAGRASYAFFTVELNHRVSERFAL
SNELRHALEADEFVLHYQPQFELATGRLIGAEALIRWQHPERGLVPPIKFIPVAEETGLI
NAIGEWTLRVACTQNRCWQDAGLPAIPIAVNLSAKQWLQPHLEDQVIQALETVGLAPELL
ELEITESLLMRDTEKMIGTMRRLQTRGVKFAVDDFGIGYSSLSYLKRFPINRLKIDQSFV
RDIPADPDDTAITTAIIQMGKSLRLTVVAEGVETLEQLRFLREQGCDAAQGYHFSKPVPA
AEFARCCAELGWARLR
>A0A143QFX5|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MTPNSHHRDRGTAAGALWAWFTQPYDYRWMADFQNSRPTGKLIRWVMTILTLNYGALAVV
ALFSDGATRNAAAIGWKAFLVVMAVAVAAAWIVKPFPGRLGVVAFAVFADLGTASSILVN
PIADAILTCALFAVIGTFCTFFVSPRWLVAHLIFSVACTVVAAAATYRTGDVDVASLIFR
TDVVLLAIAGVPLTSHLLVTVLTDDARSSLLDPLTGLLNRRGLESVIHDVWLLGREEDRC
SAVVVVDIDRFKAVNDDYGHEEGDAVIVRVAERLGAHMGRYGVIARTGGEEYLAVVSTSR
LHIDALIHGVRRAMRDPDDGVAVTVSVGAAILHASSPLWEQNLDLVTRAMRVADSMMYEA
KAAGGNRIVTTVL
>A0A6N3EBE2|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKRDVIRKNSQDAELFPFAPIRRRFLIFCIVCVLAVMFSGACLTVRRMRQSAEAAYQSAS
AQISQKAGESIKLLTSLAALPEFYDPDVPWESKTAKLDEINQYFGYMFICYVDEDIEVYT
LGEEAASLASREYMQTLYSTREIQVTDGFVAGADGRTLNYTVAVPLIQDDVMTGSLFCSI
YFDDAVNLLKQSAAANGAEAVLIGSKGQIMSSTGGLAFGASYTEILHEYKLIGLTTDKLE
TLLLARDSGSFRSLKAGNSRYTVFGPIENTNWDILVTVDFLSLFSAELPSLLLAALFQIL
ITLILYLFVKKHIFGQMAIMENLLTSIHKMEKKLYSNAIAPESVDYEDILQMSSKGLRDE
LTGLATRTFFLNQLEKLLRDGNSSGKLSLCFVDLDDLKLLNDTYGHEAGDSALKKIGFIL
RGYEKKYEGVVGRYGGDEFILILKDIDSVEELNDVLSELAERLHFSITVNGTEIPVHCSM
GACVWNRKDTLKTLISKADKALYDVKRHGKGTYSLFLNGE
>A0A6N2YQQ9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKWKWKSIASKYSLFTVCLVLTQSLLVLGMLIAGGIIKQARETVYQSFESTVTLRASSLK
DQIDNRWTNIDPYVQELSRKLPADWDENEEKAYLTDVADTLISMLRVSGTTGTFVILHET
GEAKSHAGLYIRDYDPETNSTDNSDLYQVLGPADISRKYQIPLDSVWHYGLSQEGGSQDF
YRMPISAAGQSLDYRALGYWSEPFSITPGDVSVITYTVPLFDQGGEVRGVVGVEVSEEYI
KKLLPANELATQDSPGYMIAVYPEGENHLIPLIRKGEYQKRLFGNVDRLEVKGEDGKYSI
CQVENANSRGDIYACIKSLDLYNAKNMPYDSGNWVVVGLMKGDTLFSFPYTIVRIFLFAL
LVSLVLGAIAAGIISRKITKPITKLAEKVRNFDFTRKIKLDRTGLEELDLLSQAVEISNQ
NLLDSTLKMSHIMDLMGIPIGAFEYNPEGGEVQVTKQIFGLLNLPEEDGGRLYVDNEAFW
ARLDEVRKNPEPEERDVYRDGETERWIRISMSQHQGNSLGIIEDVTADMTEKRRIQYERD
HDSLTRIYNREAFRKCAEEKLRQQKEIGTAAMVMMDLDGLKKVNDRLGHEYGDLYIKETA
VCMMKIPKEHTVVGRRSGDEFFMLLYGYENREALHEQIKSFFDTLDRHPIVLPDGEQLPI
RISAGVAWVEEEAYTFGELVGRADAAMYMAKNSGRGKVVEYGGR
>A0A6N3BZR7|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEKNRELLKTNLLVSVILVCGFLVTAFFSYQANYEASLNNIEQVASLTTEGIYYQLTALF
TRPVNISLTMAHDSLLAAHLEGEEAHLEDEQYAWTIKNYLETYREKYDFDSVFLVSALTN
RYYNFNGIDRILTEGDPENVWYFDMLKDDLEYSMNVDNDEVNGADNAITVFVNCKIYGPD
RDFLGVVGVGMRVSYLKEFLKSYEEKYHLNACLIDENGVIEISSEHTGYSRIDWFQTLEQ
EGIRSQVLGWKEDSANLELWSDTAVGGQGRSYVVSRYIPELSWHLVVEQNNGAIVSEIKN
RLYQTGVIIIAIIITVLVVITTVLRNFNRQITQLMEERQDAFKRATEQLYDNIYELNITR
NRYANKLTEQYFGSLGAGDLPYDQGLKVIAEKQIKEEYREGYVSTFTPENVIRQYEMGNN
HLRYDFKITQDGSRYFWMRIDAYIFFSQEDECIHMFTYRKNINAEKEKEIRASFDEMTGF
LTKMETGREITALLSRPAEGVYAFFLFDIDNFKQANDSCGHAFGDYCIREFTSIIRKHFR
VNDVLGRVGGDEFAAFIPAPDSEWVEDKAKELSNALRVTCTEGGKSWEMSASIGVSIAPI
DGNDFDTLYQKADAALYQTKQRGKNGYTIA
>A0A174HLZ6|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MMELKKAQKELAMLSETVLGGTARLSVDDEFRIITATDGYYRMTGYTEAESQSPPFCGKG
MNLVVPQDRPIVTEALQKLLVTNEPATVTYRIQKKDESIAWNTAYCARVDETGAERTVNV
FFIDITDKHQAETKLESLINTIPDSLIRLLIGKKNMVRYVNKEFYRQTGWQPEELPPGSP
LSQFYQIIYPDDRQMVKTQFLDYVKSDLDSCIMDYRIRTRQGDVKWMHARAFRFRSDMEA
GQIIQFIISDITEEKLQREATALNEERYRIISEQTRDTVFDWDILKDRIQFSPVYEKMFG
FPPPPDVSIKNLTEYDIVHPDDKQNVEDMISAILGGAPYAEAEYRAKRADGTYLWCRNRV
TTIFDSEKRPVHAIGLLSDIDDYKQETALLQEKATRDSLTSLLNRMALQRQVERRLKKYP
GRLNAFLLLDIDHFKEINDTRGHSMGDTVLKSISALLSQHFRSTDVIGRMGGDEFAVFLT
DLPSPSATLRKAGELKHKTAQLFESGPLSGTVTVSIGISLYPYGGKDFQTLYQKADEALY
QVKRKGGNGYFMNPPHH
>A0A5P9I9F2|diguanylate cyclase|EC 2.7.7.65|Roseovarius sp. THAF9|TrEMBL
MTTDPRLAGVGIALDALSQAAMVVDATGTILLDNRPARARYATGRPGGIVDLAAASRGQV
LAELRRVVRTTGASFLRLCRDGHATGVFKLKRLDGMCPAQNRLILMLEDQNAVMVGKILK
ASELVKTRDGALQLSKRREEDLRREARRLRELGRIDPVTDLLNRRAFEEAVRNGLRSGPG
ALLFCDLDDFKAVNDRLGHRAGDCVLQQAALRLRDVFQANGICGRIGGDEFAAWLPAVGR
AEAAVGADAVVRSCAERFPLGEGEQVAVGVSVGVAVAPEDGGDFEALMACADMRMYAEKA
RLRVCDWPDARSAPPRIEA
>A0A6N3HCR3|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEGSILEHYKNILDLVPCGICQVALDDDLTILYANQFYYDIYGYTSQDAEEKGFTNARFI
LPEADFQMIHKNLLDQVVRGKTKFQMEYRGVHSTGKILWLLVQCTYDPNIPGSVLCSLMD
IADRKRMEDEIRMSMEESKTAFALTDKYMYIFDVENRRLFQPEATAEEFGLPVVADNAPY
SIVESGTIDEESRQEYIDFYESIIQGKPKGQTVVKKRKQDGTTGWYSAKFAMIYDSEGRP
RCAIISSENITEQREKELTYQKWSQHFKAQEGKTIGYYEYNLTKDAVEAGDDPPDYLRPF
EKYTDTVRYIAERFVYEGDRARFYNFFNRDKLLLRYYNGQSSGNMDYLRKRDDGSLYWVR
ATVQLIADPYNNDVRLFMMTLDIDEEKTETLRLQRRVEHDGMTGVLNRDTFMTRVTEALE
ESGPAARHALIMLDIDQFKVQNDSYGHQFGDQVIKETAGILKHFLRRNDICGRIGGDEFM
VFLNDITCEQDVIPRIAQLCDLLKRKYPEKGEVSCSLGVVFYPRDGENFKELYRNADIAL
YEVKRAGRCDFRVYEGEAARSSLHSETGV
>A0A3S4HIX6|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MNLLRKNRSGQSRPTLGRVLQRMNLGLALIAVGTAGVFLTLVALIALRAYADHNLHLIAR
SISYTVEAAVVFEDRTAVRDTLMMIASQ
>A0A3S4DE54|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera|TrEMBL
MSEARITDSHNKVLASWHHPKDGPLHGLEQMVARWALPEAVVLPIVHGGKQVGTVWLSGH
GGSLLRFLLRGLIGMLACLALSTLCALVLSRRMLRGIVSSLDDIANVAHAVRRDRTFGLR
VPSAPIAELHELSSDFNGLLDELEAWQAHLKQENDSLTHRATHDSLTGLPNRAFFEGRLS
RAVSDSDATTKLAVLFIDGDRFKEVNDSYGHAAGDAVLTTIAGRIRAQLRDGDLVARLGG
DEFAVLLAPVHGTEDVTRIADNINRLHDTAGNAAERAADGALAQHWYCPLS
>A0A6N6K9L3|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYGDLPRLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLTDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQALSNQQLPGETERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELRIAASMTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETYRE
>A0A399E6L5|diguanylate cyclase|EC 2.7.7.65|Meiothermus taiwanensis|TrEMBL
MNPTLQALEAQLNQTQAIPEKLRLLDELYQFLRLNDLRRAGQAVEEMLILSNASNHPVGR
GLTLKNLGDFHHRQGNLPAAQGCLEEALAILHEAHEVKGEIETLSALGQLHYLQSNYPKA
LEYFLEALELSRTYEYKALEANALSDVGLVQYTLGNHQEATKYFLRSLALKRELGDRLSE
AETLNSLGLVYLEIGDFSGAVQLYRESLALMQAQGDRQGQAKVLSNLGAVFQRLGRIQEA
LDYHQQALALADQLGSPQVRAVCLENLGHSHATLGHLETALGLFQASQNLYQESGNRLGA
LSALLQVGSLLNRMGQSAAAVQILQQGLEQAAELGPQKLLLEYHQAIADVFEAQQKLELA
LYHLRRSLEIERKLHKEQQAQKTTALLAGFQVEKARQEAEIERLRNTELARANRELAQAI
ERLKEANAEKSRLLDKLRQQSAELERLARQDPLTRLNNRRYLEENLEREFAAAKRYKFPI
SVALVDIDHFKQINDTFSHQIGDDVLRIVGQILEAGCRGVDFAARYGGEEFALVFPQTDL
AGALVACERIRQRIEQHNWAALHPDLKVTVSIGVSSDPSLPNHEKLLAAADEQLYAAKRA
GRNRVCPAL
>A0A649YXT7|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MTEDDFKKSTANLKKAVPLMMQNHVAATPANYALWYTYVENAIPQMNRELETILENYGIC
PPAAGEQLYNNYVAARAETDIKDLRANIEVLVGQVASSMTDTLADTSHFSKVIDKSFENL
EKVDDEAMSIDEVMKVIRQLVAESKEIRHSTNFLNNQLETATEEIQRLKTQLAEVQQDAL
FDGLTSLYNRRSFDNDLDTLCRSEQKICLILADIDHFKSYNDTYGHLFGDAVIKGIAKRL
QISSRDGIHAYRFGGEEFALIMPNKQLRIARQFAESLRRSVEKLSIKDRRSGKQVGNITA
SFGVAELQPGEMPNSIIERADKLLYEAKQLGRNRVMPL
>A0A649YQ66|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MELDIFNPSRQLRRAVLFWLSMLLALMSLIIATLNVFFGVYHLLAIIQSLFCSFSLYVAF
NSYRSTASLLLSNCYVYSIIGLVYFTTLTYPIENGLFLWSFLYPVLFYLILGKRYGFVAT
MMGFISQLFLVVDKSFVDGVVSYFELIVNFALAYLSVWLASHILEVKRKTSEASLGQLAS
RDALTSVYNRHALIHNFDRYRQESETLPLSLLVLDLDYFKQVNDEFGHDIGDKVLVQTAA
LIDGLSDEHLVYRIGGEEFCIALHNTNIQHAMIKAEQIRMAIERYRFNNNEQPISLTASI
GIYQCDLYNDLESVLKEADKELYKAKKNGRNQVMVCNQKEQAMMTCS
>A0A7X6J5X3|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. SG570|TrEMBL
MEIESHFASFVRVLGQVAVIVYAFSWVIRTVERGVLKSVAVGLLFGVGGILSMSDPIRWM
PGVFQDGRSVLLVLTPIYGGPVGTVVAVIMMALFRFAAGGIGAVGGVVGIMAVATTGYVL
TLLPRQWIGTGWKRSALFGLATGASLIVLAFLPSPLAHQLLVSATLPAMATNFLGVLLLS
DLLEREWYRIGIQRVLENEASVDPLTRLPNRRVLQREGDRCSKEAGTRRIPFSIIMLDID
HFKKINDSYGHSFGDTVLARVADIIRQTVRKTDIAARYGGEEIVVLLPNTDTRAAAIVAE
KIRKDIEATVLTFDNNAINVTVSIGVACSDEPATDFKHVLEAADKALYRAKAGGRNRVEQ
ANAA
>A0A7X6FBX1|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. SG570|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGARALAICAGAQVDLILLDIMMPGMD
GFEVCERLKSDPRTAHIPVIMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRMRNETARNFGIEDLLRVGDGRADETGHVLLVDGRANSQERIIRALKPIAQ
VMAMSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
EMIVRALDLGVNDYIVRPIDPNELVARCLTQIRRKRYNDRLRASVQHTIELAVTDALTGL
NNRRYLDNHLKILFDRSLARGRPLSVLITDIDRFKHVNDTHGHDAGDEVLKEFAARIRST
VRGADLACRYGGEEFVVVMPDTPAEVAAAVAERLRASVENMPVKLREGGVALNITASFGI
SCRLETVETPEQLMKQADLALYEAKRAGRNRVVASAA
>A0A2N8ZK24|diguanylate cyclase|EC 2.7.7.65|Vibrio tapetis subsp. tapetis|TrEMBL
MSKKEFQKATENLRKAVPLMIKNQVATTPSNYALWYTYVDNALPELNKELDQVVDEHGIC
PPAKGEALYREYVANKTESDVQQLRQSLERMLTEVSHSMNDTLVNTNNFQQKIDKSFSSL
ERVEDEVMGLVRNLMLESQDIRHTTQFLNSQLSVASGEIEQLKEQLTQFQQDALFDGLSN
LLNRRAFDRNLSAYCLGDTPFSLVILDIDHFKNYNDQFGHLFGDSVIKSLAKRLQASCRD
GISAYRFGGEEFAFIVPNKNLRLSIRFAESVRTALEKLTIRDRRSGKQVDSITASFGVAE
FKTGEQGKDIVDKADIQLYEAKRLGRNRVMPI
>I6CGT8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0S4XI97|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum|TrEMBL
MGDALLRRFAQRLARTVRPGDGVARFGGDEFAVILERLARPDDARAVARHILAACSRPFR
LGEAVVQVGTSIGIAGFDAGTPALSAVFEAADEALYEAKSRGKGLFVGLDATQSGASDPA
>I6CQI8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVE
RQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKSSIR
>A0A1M4M636|diguanylate cyclase|EC 2.7.7.65|Proteiniborus sp. DW1|TrEMBL
MQLINSRYRVNRIFKTYDHSVLYMVYDLWNNNNELLLKLFINDSNNYSLFKELVDTFIKM
KSLRHKCIIANHSLDIVSSINNKSITMKQFFYTFDFIKGTKLSNHIGKMNIDQILYVVYQ
LLELASYMAFRGYTYKFINPDNIFVVDSRFSIKLVDYATIYEIDLKNLYDDEYNLFTAPE
IRLKQNDPKIGADIYSIGMVFKAMLSGYASINTEEKFIISKELGLSEAQKSRVIKIIKRL
TDKDCDLRIKDVSEIAREINSIFGKDYKLNLTEGRNILNFSNPIIGRDKEINNILEDDSK
LDSRIINKRLISFTGEEGIGKTRLLNELAYRLKMRKRQVYHTAISESNTRELSPIIRILK
SMIKECDIRLIDTYGCELVKIIPEISESRHIKPSPVLSGTKERFRLYDRITKFIIEHVKN
TPTYIIIDDLHNSDMETINLINYLINSSGQAPLVMIVSYDKDLLKKKRELSDTINGWISQ
KKSYEHRLLRLNLDETTSLIKSVLGISYKPIRFSTKVMNDTLGNPAHIEEAIKNFVATGE
LFINERGNWDAPTMNYTTLYIPPNIEDAIERQVKLLDKELLEIAKYVSIFNTSVSKNIIK
KIATDYNNDVEMLIDRLVSMKILDERVEDWGFTYDFYNRHIKTFIYNDISNDEKLRLHEK
AAATLENTYTQQDRGNIDELIYHYNMCNQTEKAINKIISNAKKMKGLAGNIQCIHLWENA
YRLMEETERKDKDKLEVLANLGNLYLDQGMTRKSIKSYEEGLKIAKKINSAKYLVICYNG
LAAAFYRRFDLELTRQYAEEAKKISERNGYIEELLKSVRLVNRVDISRGYYNKVFNTTSE
YLEIAIEYGFDLYIGHFYNQMGIAKLHTGFIDLAKDYFITSANYFQRSGDSVETTRALNN
IGYMYSDFLDDINTAMKYYEEGIGISRRFQSLENELTLLNNIGELYIRTNDYEKAEQYIE
RMESISRDIEDENSQFLSQVSFCLIYLFSGKFDKCHNHFDKANRLFNEGFVEDQNLHKYF
YFLTNFYLVFGNYEKALEYLHYTINNGYGENIVKLDMRLKNILIKYWSSGTIDKEEIYEI
RNLYKTINYSGERRKGLLILAHISILYGDHSLAHDLLLEDEEIKDIFTTDYLDLFRNMII
GTLNKDSDILISVSEKVKNKGYYEIELFTNIELGDIYFNSGKYYRAVNCYLTAFDLVYRL
AKKIPDKSLQVTFVNKNRASMILHRLRKVVSVVKGSEVIYNEPIEYTENTRLEDFFNIKN
IVDLFSEDIYNIGYSESSETEREIANSFEELILQLGNNYMDNLTSILNYAVNKTFASRGL
IVILDFETDQLITVASTSQEDFTPDKEIILSEIKQKNKGILVNKSFGYEGFDGLSSINDN
IKAMICMPIFKLKPLDDESNLLDRRKRNKSINLDSIIGYLYLDTDRIFNKFDSKRYKLID
ALSHLISINIDNYILKIISSVDKLTGVYTRKHFDSVFKDFISMARRDGKDFTVIMIDIDK
FKNVNDTFGHRKGDEILGRIGRIISENVRKTDIVGRYGGEEFIVVLPDTKLKEGEMVAEK
IRKAVEKSNLINENYPVTISLGLSSYPEHGQSEEELIEKADQASYIAKETGRNISVSWSN
DVGKSRKRLDRLAGIVTGNTVKDQRIGLVIIEIIDIAKEKADKEDKIFRVLGRIIEALEA
EKGILITLDEEKNIESAYGRLRFSDAWIDDLEYNKKTIYKAINEQNGEYFIDWEDIREID
LVSGNPNWQSVIVVPLVNNGLVKGVLQLTVPIKEKEFEYNSFNLVNNLGGIIAAML
>A0A8F8H1B4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A1Y5ZRS9|diguanylate cyclase|EC 2.7.7.65|Bacillus mobilis|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCTHQQTIENIHPKCMFIANSFEEGELLFQR
TKPHIVIMYVTDFSQIKYIKNMYNPQSTFIVIWDQQITSEFAEVLTLGIRNIVIAPVTPQ
MVLEEVNKSLYQLSLVRQVSLQQELLQMMFDFQNDLLFIVEDDEIVDCNTNFLEFFGYEN
LFAYREQHLVFAEHFIRENGYYSTTHDITWLDDTLSYDRRIKMSNYEGEVSTFLLRATPL
PEDLSRFIVKCTEITELDEIYQEQERLAMIDSLTEIYNRLKFQQILEAEWDNAMRKDEKI
ALILFDIDNFKTVNDTYGHDFGDLALIQLAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFSGISKLTASFGVALYEQGITREELMQRADIALYEAKKNGKN
QVCVYRKEKK
>A0A1S7NB54|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum S56|TrEMBL
MFTVLECVAVQHDHAIVLLAAVICLLGMHAFFHLLLRAEESPAGRKPYWVLVAAFAAGLS
VWATHFVAMLAYKGSVPIGFDFQFTALSAVLAVLGFWLALRARSQASYSPVIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWVFFLLAFFLFLRFAAWKRIVIPAGCSI
LAICALHFTAMSATILSPDPSVAGPDPDNLARVIMIAAVSGVTFLVLAATATAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLVGSDEVSLMGKNPDDLFKAMDGQPTYLP
RLAPVEAIRERADRPQVFELAVRTIEYRGHPCEVLAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDAEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVATILDE
CARPGDIVARLGGDEFVILTARHTKSEEARLLAETILAMFGLRMNAANDPTAVGVSIGIA
VFPRDGNSNESILHAADLALYRAKMGGRGILSFYDPLMDQEARERRQLETDLRLAINRNE
LVLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQASTWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQSGLSPNRLELEITEAALLKDRKAT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSEDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGRPDVAPAAAASTGKRKKHSV
>A0A517TJ63|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium MalM25|TrEMBL
MPSSSDQTTPVLNDFEALLGVAKTAFALLSERGELVWWNEALTRISEQHHQSPQAMITQL
LPPYGALEPVSFGDEGLRLIEIPSQDVLMVSAASEPRLDSLTGVLTREAFSDELDQAFAV
AQEKPFALLFIDLNDFKEVNDHHGHLVGDDCLKSVGERLASVVRVGDSVGRFGGDEFLIL
LRGVAVAPLLRPIEKRLRASVCEPIEGPEGPLAIGLSLGAAYSRDGYATPAEMVAAADRA
MYRDKRADRPDVD
>A0A1J1LIR4|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MKKIKVGILYSLSGTMAMSATPLLESTLMAITEINAQGGILGHEIEPVIEDGASDILVFE
KKAKKLLEIDQVSTIFGCWTSASRKAVKPLMEEYNVLLWYPIQYEGLESSPNIFYTGSCL
NQQIQPAVSWVLQNLGKRFYLLGADYVFPRTAHKLIKSLLKQEGGTVVGEHYFPLGDKRF
FDIIDEIKNLKPDVIFNTLNGDSNFYFYQAYYEAGISPSEMPIVAVSVSESEVQTMGKAS
VGHYACWSYFQSLNSPHNQEFVNNFKALYGTERVTSDPIEAAYFQVYLWKNAVEKANSFE
TNFVKKAAYDQTFEAPGGLVKIESNHHLWKHCYIGRVTESKQFEIIWKSPDLIKPLPWLG
VEELKNFPQADLVIDMLAEVSQGIQYSCLLEANSRRLELTMQQLKTEIEERQRIEITLQE
VNKELKHMAITDSLTKLANRYWFNECLKSVWNQHLITETTLALILCDIDYFKNYNDTYGH
QKGDDCLQQVAQAIKTAVRNGFDVVARYGGEEFAVILPHTALFDASQVATRINMEVQQLQ
IPHKTSLVEKYVTVSLGVASQIPELHSSPEVLIYEADKALYKAKNNGKNQWCLHYISEQG
TGGKRGTQV
>A0A2X1AQ62|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MTTQVETTVRSPEAYALAHRAVDAMQEASVWPTPLNFELWLHYLSAPDSPLSQEMARLLA
SGAPFTDTTAEMLAAEFLPRSRLSEEIRDAGAVLNRELAAVAAAIDKARESQADYGDTLS
QAVDRMASAPDTDSLGVIVSSLSDATRRIRRHTSALERRLESSNREVVKLRDHLEQVRRD
AMTDALTNLANRKAFDEHLQRMCDEAESDGTPIGLALIDIDHFKRFNDTWGHQTGDQVLR
YVASVLARIARTPRIAARYGGEEFAVIFPRETAGAVEAALNAAREEIASRSLRRRSTNDD
LGAVTISVGFALRHSGEAASHFLGRADEALYASKRTGRNRVTNAELAASAAA
>A0A679JLX8|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MPARSLMRPSWAATTDKAKGGFSSRHFLRLVESSIDIGFWSGDLDGELIEGSIGLYRVFG
LDPSIALTFGFAKEMMHPEDRARHADLLPLLRTGQPMQREFRIIRPDQTQRWVLHRVEVL
IGPDGRPKLAIGMVKDVTPRYEVEMSVEQGNDRFKALIEATAAVVWTVSPDGRVQDMPQW
RMLTGQSQAEVQGDGWLEAIHPDDRDLTASAWQFSVSHREPYNTDYRLQLADGSYRWYNA
RGVPILNRDGSVREWIGICLDISDRHRVSSSSAKAAGATAAQDITVEQIRGARGMTGLSA
EELGRRAGVSVSTVRRLESEATTTQARPDTILAVRQVLEAAGIEFTFEANAKPGVRPA
>A0A6J4FYH7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MKEPVQPRLLHALSDAAEIGLVLTDGHGRVMLWNDWMAKASRIAEIDAKGRRLDEIFPQL
DGKRVVAAVDDAVGKGLSAVLTSSLNRTLFPLWHDGRIPGKPEPMHQIVVVKPVNDDGGQ
QVCLVQVFDVTSMAHREALLRQQARTTEALAENYRLSELHNRAIVDNTADAIITFGADGA
IGTYNPAAERIFGYDPYEIVGKPISVLIPELVTDHGGIDAAALSGEHRERSGLRKIGATF
PLELSVSEMELGGQQLYVAIAHDITERKQAEEDLRTQKEWLSTLINAMPDLVCFKDGKGR
WLVANQFYLDVAGLTGIDYQGRSAIELARVCKGDSDFLLGTLASDERAWKERAPIGYEKE
IKSPGGTPKIFDVVKIPLFHGDGSRRGMVLVGRDVTERKLAAARIEHLAHHDSLTSLPNR
VLFQERLRSALGQAKRNDFRVALMFLDLDKFKDINDTLGHHVGDMLLKAVAKRLQRCVRE
TDTVARLGGDEFAVVLTNLVDPEGASNVAESIISAISDPFGLDEHEVLTSTSIGITLYPD
DATDSDTLLKNADLAMFRSKAEGRNNYHFYISEMDAEVQARKVVERDLRLALGTEQLELH
YQPLVEVATGQVVGCEALIRWKHPTRGWVSPAEFIPIAERTDLIAPLGRWILHRACLQGR
DWAREGLPPMKIAVNLSPAQFKHHQGLVAMVADILAQTGLPASQLQLEITEGIAMHNIDA
TLEVLRQLREMGALISIDDFGTGYSSLNYLKRFPVDKLKIDRSFVVDIGLHPDNAAVVQA
IVNLGHSLGTRVNVEGVETREQLDFLIAHKVDEAQGFLFSKALPADQFAEFVTKHSPWPI
HQG
>A0A2H6IPU3|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MTNKSSENKGSKEINDVYRDIVVSTNTLIWRTDAEGRFTFLNPAWEKIYNYKIEEMLGKP
FSDFQVPEAAGHYINAFRDCLIGESIIGHETAFSSKGGDEIHLAINMIPLHDDKDAIVGI
QGTAFDITERKHADDILQYISAKDELTGLYNLHTFLSMTEQQIRTAHREKKDILIIYAGQ
QNIKKIIEEHGEEAGDRVIIDAANILRKTFREADVLARTGGSEFVISTLVLSKDGEKLIF
SRLHKNIDEYNKDKNGSLKLLMSFGTSFYDPEKPVSINDLLSTADDEMYKNKYS
>A0A1X6YJ83|diguanylate cyclase|EC 2.7.7.65|Roseovarius albus|TrEMBL
MTSNRANLNVDVLDAFCPLHVVVNKSGHITQAGRAFHKLCPGQDAVNRRILEVLEIKRPG
QIYTLDDLLEAVGTKLHLQVRNEHRTELKGLMVPLPNGGGAVLNLSFGISVVEAVCDYEL
TNADFAPTDLAIELLYMAEAQSAALSASKKMNLRLQEARMMAEEQAFTDTLTGLKNRRAL
EPILERLIDREQDFALMHLDLDFFKAVNDVQGHAAGDQVLKVVAKRMCHETRPQDSIVRT
GGDEFVIVLPGLKDAAQLDGLATRLIISIEGPITFENQLCKVSASIGTVLSLNYDSPEID
RMMDDADVALYGAKREGRGCHVTYRTALRLDDTSDHSADDQRAVS
>A0A6J4FLE0|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MPAMTTTAMLDHELLELVSSLVCLLKDGKIDFVNHAGARMLGLAGQAEAIGTQFEDFVVT
DYRFLMEAGWELLAEEEFLPLKLLRTDGNAFEAELRVRRVPAPEEIFLLEVRDISKFVKS
AEALREREERLQGVLASVAEGIVTINDSGRIESANPAADRMFGYARGKLVGADLVTLLPE
ADRERHHRFFDAYMAGLFPTLMGRQVEGLGQRADGTSFPMEISVSELRHGRHRLFTAILR
DISERKENEERIRRLAHHDSLTGLPNRNLLNDRMRHALARAQRNKSRMALLYVDLDKFKP
INDTLGHEAGDEVLREVAERLSQCVRSSDTVSRVGGDEFVVLLETVARPSEAALVARKII
GSLVKPIDYKGNICQVGASIGGAVYPDDGESMDEISKAADIAMYRVKHAGRNDFRFYSEI
TESELD
>A0A731V2M7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A6TB76|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A4R0GGW3|diguanylate cyclase|EC 2.7.7.65|Enterobacter wuhouensis|TrEMBL
MQRDTYVLKRSFLQWLHKRSNPGLIVNLCFLVVLIFSTLLTWREVVVLEEAYISSQRNHL
ATVATSLDRQLQFSVDKMLFFRNSMRDALQTPLAFGVLHDAVGRFETLRHTANWQIAVDK
NRTLPINGVSDAFVEKTTLLNRDEEHLTNELSAALEVGYLLRLASSGTRKEERVVYVSRA
GFFLATDTPARPQDISPRYYQLVTLPWFREQSDRDNRARAVRWFISPASVFVGNQPFITA
SVPIYYNHYWYGVVAMDFTFATMKRLLVDAMDDRAEGEYQLYDTRLNMIATSETPAATGN
QFDEREMAQIARAIETDTQGGIRLGSRFISWERLDHFDGVVLRVHTLHEGVHDEFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHTLQWQAWHDPLTRLNNRGALFERAKMLA
KQCQQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAGGLIASALRPNDVAGRVGGEE
FCVVLPGVGLAEASAVAERIRARIDSKEILVQKSTTLRISASLGVSSAQEKDNYQFEQLQ
SIADARLYEAKQGGRNRVVSNGHEKK
>A0A6N3R2Z2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMR
ALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAAL
LPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQS
GSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLR
NIFYTHDRPLLWRFLNVTLTDTDSGREVAKFSVPLQKPSQ
>A0A5B0KDG2|diguanylate cyclase|EC 2.7.7.65|Pseudocitrobacter sp. 73|TrEMBL
MHPVAPEKSPGWLRKLSQHSRPGRVVNLCFCIVLLCSTILTWRETVVLEEAYISSQRNNL
ENVAREMDGQLQFNVDRLLFFRHGMQAALQAPLAFEVLRNAEAEFSRKRHEPDWHIALEN
RRTLPLNGVSDAFVEQSDFLSRDNPLVANEFTAALELGYLLRLSSITGQHLSRFSPRMLY
VSRAGFFLSSEPVTRNITEQFYELVTSPWFIQQSERENPGRGVRWYTTFSSDKQHEAQMV
TASVPLNYQHYWFGVLAAQLSVREMGEFLLRAVEGETEGEYQLYDSRMNLIASSNPHVTP
LTQEVQAQLARAYEENNRGSLREMTRYISWEKLRNFDGVLLRIHSLEEGIKGDFGRISIA
LTLLWILFTGMLILSWMVIRQMVSNMSTLQESLQWRAWYDALTRLYNRGALFERAATASA
ECRQAGKPLAVLQLDLDHFKSINDHYGHQAGDRVLAHIARLIANKIREGDIAWRVGGEEF
CVVLPNATLAQAREIAERIRECINRREILVSKGQTIRVSASVGVSASDDEQKRYDFAYLQ
SVADRRLYLAKEGGRNQVRAKD
>A0A2X4U507|diguanylate cyclase|EC 2.7.7.65|Leminorella richardii|TrEMBL
MKKYISVLYTRLIKRAIVHSVSLDRIEDERKVKHVVYTNIFTAIGAFAFVPVHLYIAQST
LAALCNAVCGFLGIVILLDLWARGRLKQSVWFTVILSSLLVIIVFWALQGEYQISAYLVI
PAGFAFLLLGGRQGIAYSLCYFFVILILILSHIDTWPAFNQNSAALLNLLGAIVLSLFWG
HIGEYIRGGSFQELEVIADSDTLTSAINRRSFFAHLHELKRRAEAEGITFAMMVIDIDYF
KSVNDGFGHDSGDRVLVEMVKLMKSTVRSSDIVGRIGGEEFALLLPNLTKIEAVSKAGRL
CKRVQRHVFTSVDGSKIPLTISIGVTVVTPDRDISVEDIYRSADRQLYQAKKSGRNRISI
DAR
>A0A6N3R6G4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>K9NH45|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MSNFIATDEPPEAVRLMVKVYACLLLAGFALVPAYLIGYLHYFQDPTLLFENHLFHIIAI
TAATLAGLFVTYVTWRCYQSSGEPLLRWMTLGFLGFVVIYALHGAFTGLAHHNIWLFLLY
GPASRLVMSVLLLVAMLSYHRPPDAADQRMKARPWLIWIGLFLLVDVAVAYVANSPIAGN
LAVRLSMEGGALVLSILTVTILLLRRIRSPLMTIFIISVTAFALSSLAFILARPWNHMWW
LAHAIFAGGFFMLSYGVVQAFLTTRSFSRIYSQEELMVRLAEAMAYAENALQELQRTNQE
LGHLAATDPLTGADNRRRFMERVEGEIGRTKRGDAPFSVLALDLDNFKSINDRFGHQVGD
DILKSFVEKCLDSIRPYDGVARVGGEEFMILLPQTSLEGAHEIAERLRSTVANSSFHGLQ
RSTVVTVSIGVSQSGRDGDTIEAILRTADQRLYHAKHQGRNRVVTAFKTSLQPLP
>A0A4U6MN43|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. TBCS-14|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGMWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>W7P2Y7|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MISVIITMTLIWLLLCIASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAASETLAA
LGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVSRWLFPVPVAQPIMHNGLTIGE
IRLTARDSLISHFIWMSFAVLTGCILFAAVVAFIITQSLHRGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMMEFGDKRHQ
AYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENA
SVEALLERADRNMYQVKNQRTKTIS
>A0A3S4G627|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MALVSLEGYWLRVNPRICEMLQYSERELLERTFQDITHPDDLNIDLALLKQLLACEIETY
SMEKRYYRADGSIIGVQLTVALNRLPNGNPHHFISVIVDISERKAAEADLFALQHELEER
VELRTHELSVVVNKLNLEIDSRALTEHQLSAEKERLRAITDNMPALISQIDNEERYLFAN
SAYKTWFGLDEARLKDMTVRELMGETAYAKANPMIEKALCGETVSFENELQTRQGLLMIH
TTLVPCETQGFYILSMDITELKRLQQRLEYDVTHDMLTGLTNRRAFLRRLAGTLQRCCPQ
QQMALLFIDLDGFKAINDTFGHDFGDLILKTFAKLLSACAGTNNSASRLAGDEFTVILWP
LMDPERQVTEFCEKVLTQLAAITQIGNQKVTLSASIGAAISSDGNLSAEALLSKADDAMY
QAKSAGKKTYTIR
>W7PFQ7|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWGSVSFIYPSINVIEAAIGALFLRKWLPWYNPLQN
LNDWIRVAIGSALVPPLVGGLLVSLLAPGPEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTAQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSMMSLDEQWHMIKDNHLMIIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTYAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>W7P4E1|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MSQPCFDALNVIKTPVWLISPVSEQIIFANVAATQVMGDKTLDDLRKGTYSANAQLLLSM
YVPELKTEQEIVEIWTISWDGQDTPLSCRLSLAHYAPWGDVIVFEGTSPQLLSGLKASRS
ATYRRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDDMCSKHTWEIN
TLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELEHAALRDSMTGLLNRRQFYAITDQNSLNYLPAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSREGDMVFRWGGEEFVILLPRTSLDTALQIAESIRAAVA
RITIPGLPRFTVSIGVARHDQGESIDELFKRVDDALYRAKNDGRNKVLAA
>A0A0G3EFI0|diguanylate cyclase|EC 2.7.7.65|Kiritimatiella glycovorans|TrEMBL
MGLLAVTVNWDFLLSRAGEVLIVVAISFAVLTVLMSLYRYQTLMERSSSEGEAAPRFPDL
EGDPLRLMVARRVGALTDRSRHFGLLLMDPTPLAGEQLERLADGLRKHIRSNDDLAVSPD
GRIGILLETGIEGMRRCIERLDRVIRREYTLTDGEGKLRIGAAACPVHGRNSKALIDNAA
GALDEPDNFPSTPGRDEPEDAEEEDLAASDRAMLDPLTEVLRPDKVASFMRKFLGQQRRG
TELALFFLGLNNMEEIEEFEGEEAADAVRKGLSDIMKRALREEDILGRFDADHFLVLLLC
SQDAAPGVARRLHETVRRERVEWQGRRLQVSINIGVSLCPEHGKNIPRLFRAAHAAYRTA
VERGGSMCEVFGHSSRQTLVN
>A0A2S6U1W8|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha4_Bin1|TrEMBL
MRQTENIYRVMIDRMQDGLYRVEGERFVFVNPALADLVGFEVAELEGQPYRAIYAPDSLA
RIDDFHRRRDAGLDVPNRYESVCLHKDGVTRIPVIINVELVTLGDGRIVRIVTVTDITER
VRAEDALRASERQLSEAQRIGRIGHWRVDPKTHKIECSDVFFEIYGWDRAHITPTLERAV
SSIHPDDRTQMNALRNAAVEDRRPYKFVTRIIRSDGEIRYLRGEGQPEFDRNGQLCSIFG
VSQDITEQRKIEQELLRERHRAVSASNAKSEFLATISHEIRTPLNAILGFS
>A0A399F8E5|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MDATALDPHTPLVSAQQALEVAQSSGDPARLGKAHNQLAQVQALQGEFVQALGNYLAGLE
QSRQAGHKGLEAFALAGIATLQQSLGNSQEAAKYFLRALALEREGGDRARVARLLNCLGQ
VYLETGDLAGAAQLHREALEIAREIPDRPGEASALSHLGVVYGRLGRHLEAIQFHRQALE
IASGLGQPQTQALVLGHLGSALAAQGDLKEALELHSQALELYRTLGQRPGEADALLRVGM
VLRGLGQSEAALQTLGAARSIAQELGAKRTLVEVYQALSTTYEAAGDPASALEHLKTATE
LERRLFQEQGAQRTAALLAGFQIEKVRQEAEFERIKSAALAEALEKAQAAEQAARQAESE
QTRLLERTRQQAEELERLARQDPLTRLHNRRYLEENLEREFAASRRYRFPLAVALLDIDN
FKHINDRFSHAVGDDVLRLLGQLLENSRRETDFVARYGGEEFVLVFPQTDQAGARIACER
LRSKIERFGWQTIHPDLQVTVSIGLSDDPQAANHEKLLALADEQLYAAKRAGKNRVKPE
>A0A4R0FRL7|diguanylate cyclase|EC 2.7.7.65|Enterobacter quasihormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESISITYTAINIIEATIGALLLRKLLPWYNPLQN
LNDWVRLALGSAVVPPLVGGILVHFLVPSAEPLRNFLFWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLEQLIHGEINTYSLEKRYYTRNGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPAHIKPSWQLWHDAIV
PEDRANAERVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNITFMNPVAEKMSGWSQSEALGQPV
LEVLHITFGEKGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLDGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFFD
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINSYHFSWEGRLHRIGASAGITLIDDSNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLGEAELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
NELLDLITKGPMPARLLHLAIAVDVLNNTDENVQQGLQKLRHAGCRVVLTRVGRDMNVFS
QLSATTADYLLLDADVVTNVHGNLMDEMMVTIIQGHARRLGLKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A5E4SSZ2|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MKSTISRTEPGNRVAATTILVACAAFTLAGFLARAIRGDVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGITTPVTHAPFWLWLMAEA
SFAAYVMLSVRSYTRTRSDPHIRPGYKEAAWYGATVLVIWATVSLALVGTGRPLVMPRPV
GGISVETLALCALFVAYVALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPNDAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFVDPLTQIYNRRYFDNR
IRLVADRVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDTVLQRIASTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQQAALRVADRIRESVKRASTDMLPEKARDKGEAITISIGIATWQP
GEPLVISAMLERADKALYQAKHKGRDQSVLGQLAA
>A0A560BLF3|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALADAEAISGIFYAILLDRPDSNTFL
SHALVQERLRPSLARWIGALFTASSDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRII
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTNRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRTVEEHRFHGAGGAGNGLQVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A377KS59|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MFVHLIYAAIYSVLVVSLLISYDLFIKNFKELNLRLSFKILTGIVLFISQVYFIISFSLN
SIGYVAYEYTIPIFIYYFGILKEKIYLVGLVPVILLTFFALINKFEWEAMLFIIGLNYII
LIVTGLLKKRFYGQPNHTAFYLFSIFVTVVSPMLNALLFYRREISVWDVVSLGIGSVGIV
SLWKYYLQNQKNFLEKINTKIIERNYDELTKVKNFRSLNEDISKLALLEKDQLVVVMMDL
DHFKRINDHHGHQIGNQALSFFSEKLMTFLYQKSPSHLVEVYRYGGEEFLVLFKENTSDA
VKKIIEEFHLFLSNEQLKLETAQLTLYFSAGISEAASALDISETFYQADQALYEAKRKGR
NRTIIFS
>A0A291DWB4|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MIGNAFERFLSRYKRPQRVVNLCFIVVFLCSTLLTWREVAVLESAYISNQRNSLDNVATA
LDRQLQHSIDNLLFYRNTMHYALQSPISTDISRKTLTDFAVQRTQPYWQLKLDLNRGMPI
SGVSDEFVAHNSLLSRDENWLYPELGAALEFSYIMQLADAKRDLQRRVFYASRAGFFLSS
TPPENDPAVVSLYHRLIAQPYFVAQSPANNPGRGLQWTHTFNPGSHSGQIITASVPLDLN
NRWYGVLAMDFPINAMHEFLQALSHDRYEGTVMLFDRQFSLIATAADRVSPAPVFNAKQQ
AEIARSMESGEEGELRMDTRFVTWAKLMNFDGVLIKVHTLDEGVQGEFGRISIVLTVLWL
LFTLMLFISWRVIRRLVNNMLTLQQTLSWRANYDTLTRLYNRGAFFDIAHGMAQTCQREE
KPFSVIQLDLDFFKGINDRYGHHVGDKVLSHAAALLASSLREEDVAGRVGGEEFCVLLPG
TRLPEAAAVAERIRHRINTKTLLLQAGQTLKISASFGVSCAHERHDYDFEHLQSIADRRL
YKAKQNGRNQVCTQD
>A0A0B0HS48|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus sp. BCO1|TrEMBL
MFKQFIANSGILIAGFYLISKFFPSNIHQQSPVHMRLLAGAFCGLLSIVLMFFSIPLGHG
VISDLRHVPLVVVSYYGGMPSALAAGIIMGTGRFLFGNPFASIVSFFTSLAIAIGCGWIS
QRMKRHITITTFWMNVYSMCLISLALFINIPDKHIYTQTLVIFWPISIVATYVAANICKD
IRQSKDMLQHYKQWATTDFLTGLYNVRQFHTLFGQHLEQAKQKNSCLSLILFDIDRFKLI
NDTYGHDGGDVILRDLGELIRSLVSKNGMAFRNGGEEFSILLSSCEHEAVTFAEHIRTTI
ERHPFFVQQQAVHITVSIGISVFPTLATNEAELFKQADIALYEAKQQGRNRTIVYKKEYL
HET
>A0A517RQ34|diguanylate cyclase|EC 2.7.7.65|Gimesia alba|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGSYMGWPLGIAPLLLLAPITVLAAISSPRVCSW
TITVLAVGACFSEIFFRSDISEVKTTYPLSIMSAAVLIGLTLLIDAYIGKLRGKLSQIYN
QNDELVRQLYECQRETQPVSDKSPSGADKKEKMQVESKENPDAEFGVNYPLLLLTLQDIG
RRISTNQSNESLIPTVISTAKASLQCEYCQVYLWDSKASALKNALPVRSRDKHEYRPVPN
SGVAAWVIENRQIVMRNDAEKDYRLKRILEEDPHMPDAIAPLTVGSELIGLLIIDKVDIE
SPTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLLNHATFQDKLQELIKNAEAQ
STTLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPENAIVARYGGEEFIGVLA
DHEYSQAVQIAEDLRETLENCPILFEGQQLQVTASFGVTELRHPATTTNELVKVADEYLY
KAKEAGRNQVAGIAPNSARKPSN
>A0A3P8L411|diguanylate cyclase|EC 2.7.7.65|Tsukamurella paurometabola|TrEMBL
MEKTIVGEGTPRHLLRRIDMQDRVWRYAIAALTLAYGAFGAITLVIPDGAGDSHWRRATI
GLICLSAIPAAAVVARTPLAGAWWSKGARNRGSIAFVAYADLGLAGVVLCMQNAQASLIG
TGLFSVIGAYVAHFVDGKVMTLHITFSTTVILILGAKLLAAGTNPITVSLEIVVAIVVAN
AVVALLRRYTVEMQRLITKQLLESSLDPLTNILNRRGFAFSGGRLVDRSPGDLLVAAIDV
DEFKTINDRFGHAVGDGVLRNVARLLDTGTTPGAVVGRLGGDEFAVISADPAHDATFLTD
DVHRDPVRLPDGSTVSLSIGLVHVDHVSDSAVPSLDDLNDRADRALKASKTTGRNRTTSV
EG
>A0A427V2R6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTRKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQNFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A3S4GJ77|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MSDQEFKRALGYATAAFDLLKRSGIPPYPQFYELLYTYATGVNPSLNNRINAIFRGGTMP
SAELAETLYYEFMKSDANERMSSVSQRMHARIEAVHDAIDSAMTTANAYSGSLQSATGDL
ERDLSEDAMRQLAQRLLSETRRMQDTNRQLEKKLEASRDDIAALQRDLDDVRRESMLDPL
TKIANRKSFDEGLAGAIDDAKRTRAPLSLVLVDIDYFKKFNDTYGHQTGDQVLRLVAMTL
KSNIKGRDLAARYGGEEFVAVLPSTDLDGAVIAAENVRKAIQAKELLKRSTNEKLGRVTA
SFGVAMFRADDNASSLIERADRCLYAAKRAGRNRVVAEIDLVEIDVTASTGVSAA
>A0A1A8TNP2|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MTDHLFFTPSSPLENSIDDLKTNIRQEQSVWHFLFENSPEAIVLIDRYGSVVDANQAFSD
MLGYTRTETHQLHLWDWDDNLEKNVALELLNNPSGKGVTFETFHRCKDQSIKSVEISSSS
TSLDGQPLVICFCRDTTEKKQRDQRIQELILRDPLTNLLNRRAFNYRTKRALQHAQEYQQ
EFSMLLVDIDHFKMINDEHGHSTGDQVLAEVATMMASQVRDKDSIARWGGEEFALILPGT
DQQSAADIGERLRQSFANLQVGNIALISASIGVTSYQAGDTLDSLFKRVDDAMYRAKQCG
RNCVMVSP
>A0A554X732|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MIADPRARVRLAQLHLYVDVHRHDRFVAPVLTVITGLLLSHWVPMSWALTWLGIELLIIA
HYLWVYRRFKQAQPPPSEERRWANRIALAHGAHMLAWSSLVVWAWRPGDFGNLMFVMLVH
VGLISLTVSMSHAHLRLLLLDMLPPVLALIAPPLLEPSAFHIGLSALGMAFCALMLLVGR
QINAATTEAIELRQRNEQLIRELQSQASRDALTGVINRRYLMETGARLLQQHRHSGEPLA
LLIIDLDHFKQINDLHGHLGGDEVLVAVVNTCVQLVRASDCFGRLGGEEFALILPNTQFA
QARDLAERLRTAIAALAISVKTETIRPTISVGVAMASDDDVTLSDLLRRADMAMYDAKAG
GRNRVVCAPAGGRHTPQPAHP
>A0A0Q0P3G1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MLNSLSRGLNLRRLILVLAFSATLITFLNSYYSSYQVQKQQLIDKTLNNHKAYAAKLVSA
TDNFLLNAQQQLAYVGKILEDDFNNQGLINAEADRLRLQTNSFNSTIIVNAQGDILGVSP
KSLKLQNRKVDSFGTKAALSYRTPMISEPYISMAGNLLIFISQPLFDKQSNFIGYVGGTL
YLKRTSILNELLQVHYYQDGSYLYVVDENHRLLYHPDKSRIGEQVFDNKVIEEVLKGNAG
TQLVTNSKGVEMLAGYAPMTVASWGVVTQRPLENTLAPLDNLMWQVFVKTAPIGLLTFIF
IWVLARLIAQPLRQLAETANTLDRPSTSLELTQIRSWYFESNELRKAMLKGVGLLQSKIG
LLRQEAQTDPLTCLHNRRSLDMQISHLIAQRCPFAVLAIDIDHFKRVNDEFGHDIGDVVL
QSLAKILLDVTRDSDVVARTGGEEFIVIMPRVEAKRAYQLAERLRMRVSESYIDPVGCIN
VSIGISGWPIEQLNIDEVFKLADQALYQAKKTGRNRSVVDATYSQDLAPVSELSILE
>A0A0Q0KQH4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MGAFAAKLFNQDMTIDRYACQFKSLQVEQIFLQSKFAQDKKIAQFFCCIIALVTTLVTFF
DKMIIQASFWPDIALTGRIIMVSVCVLSAFGLSYIKTIQLFRLVISVFMLFLFLNMQFMA
ITYERFYILHMFFDLIILITFYFSTLVSIKLSVFLSTLYSALAISVIYFNKEISNHSLYM
VILAHLAANLAGMIMAAHEHIIRRELFVRNAQLAQLAHEMKTQALRDSLTQLPNRRAFDN
AYPEYQRLTQQQQGESKQVCVILADIDYFKRVNDTHGHEVGDVVLQYFSAFLTQSLRTSD
DVYRFGGEEFVIVLPLCSVPDATVIINSMISRLNAEMFQVEGLSLPIRASFGLTVMREEE
QKLVIARADAALYQAKDAGRNQLVIKL
>A0A8B3K1V1|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSLNLAYTFVNIIEACVGALLLRKLLPWYNPLQN
LNDWIRLAVGSALIPPLVGGVLVYLLVPNPEPLRNFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTTVITLVLCWAAITWLPWPFTCVIVLLMWSAVRLPRMEAYLVFL
ATIMMVSLMMARNPASITPQNVIVAFNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLVSGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDAMV
PEDREHAEKVLRDSLIARLPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICTDIDMNVTFMNPVAEKMSGWPQTEAIGQPI
LRVLHITFGENGPLMENIHSGDMSRSDIEQDVVLNCRNGGSFDIHYSITPLSTLDGHNIG
SVLVIQDVTESRKMLRQLSYSASHDALTRLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNLESARYI
AGRLINTINNYHFTWEGRLHRIGASAGITLIDESNHQAAEVMSQADIACYASKNSGRGVV
TLYEPQQERIHSNRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESASFWLLSLRLWTSQ
GEMQEEHAFRSGLAEPELLHALDRRIFNEFFRTFAAPVAAKGMGVALPLSEAGLASVTLV
DELLDLLEKSPLPGRLLHLVIPVDVVRNPDENAQRNLQKLRHAGCRVVLSHVGRDMNDVN
HLSPNMADYLMLDTDVVNNVHGNLMDEMMVTIIQGHAQRLGMKTLAGPCHQPIVMDTLSG
IGIDFIYGDTIAEAQPLELLLNTSYFAIN
>A0A485M554|diguanylate cyclase|EC 2.7.7.65|anaerobic digester metagenome|TrEMBL
MTVNLSHFFPFMLPFLASLLVSASLIILITRFAEVKKEFRLLAACCMVSFFWNLSCLSLS
LFPGSWTAALLVEITRPLPVVVIPLVLHLIHRYLDAKGNTIALWIAYILSFLMIGVFWID
GNEEIRMAPFFIASSAAGSAYVYLRLFSIPDHAAGRERTLNRGLMAAGSVLFMALPGLDA
LSGGSWGFFGFAFVPLVLISSAMTARPGDDLKNTPTRENLLHTFIISFVLFPLICDLIFV
LGSVHDLQVGDFLSWRFHHTTITAVSLLATAGCVLFSLRKVPGRVDALLYVVICLLVCVV
NLRDLIITGLPEDFSRQIILINDIFLVNLMGICAHLVLITCRKAGQGNVVLPYVPGLLLI
PLLLYESRQGVSLFPSGIFALVGLGHFLFITISLVMLFWCIFMLVSAYRHERNPIRRRAT
AYIASGTAFAVLILTGNMITTIGLSSYPFYNLAFISLILVGYGLFYSDIRSMSVQTRRQT
ISQGLRLLLSVLYLATALGVINVLKDYPVSHITSSIIPYGIPPMLSFLGAGFLSLFVLGL
ERNRPESQLFSLISFCYTALNLDIFLQCIVTDPTLALIISRIDHFFLSLLLLGVNIHLIY
LVIGKKDGWWVVYAAYLAGLIMAPLSQTDLYFDGMHSYYFGFFAKKAAAYDFMSALWGAG
ICYGIFLLYRAFKDPRTSQRTRVKHTLTAFIIIAVLSITNNPAIYGYEIYPYGTFIFIAL
FFLAYGLFKFNLKMALQYIRIVFFWLGLALAMIVVGFSPALFLHEGQETARALTGTLLVV
FLFQPVKRGWTTVLDLFMTKSEDTLKDSYYMLTSKLSRIHHRETIHQMLYAWFFENIESS
SFASLFSLPDLSGRQVFFGWKTWNTQNDAGLFADSGARDVESKSLHVRDDHPLIKICKRE
QALCTQENLVRMNPSIHTFDGREGLIKDSEVIIPVIYKGELLGVMLPGRKADGSPYSRTE
FEIFQNISLVLGPLIENAMLLEGLEEKVNLRTRELNRALAESVRKGKELRENSDIIGRQN
KIFRTLLETSTRIHHLDNLDELFSFILSQLHTLFSDFRGGIILENRRRGILEAMSFLGIS
EAEQKMILELREEIMTSEFGDTLNQALAARGIPASPGDVWTVFPMEGRDSKMMGYLIFKG
QELDRLTKEIFAVFLGQLSAVTQNKLLMIQLERMASTDGLTGLYNRAFLNQELKKVIDHA
RRYRNMHFSIMIVDVNGLKQINDTYGHEKGDEAIVLTGRMLRSVCRQTDVAARLGGDEFA
VLMPSTSLSQAEILYGRILQAASHLKISVSKPGEQPAVIPIHISVGLACSDDTPPDMVMK
KADALMYDAKKQYYARLKTARG
>A0A2K8VU17|diguanylate cyclase|EC 2.7.7.65|Dickeya solani RNS 08.23.3.1.A|TrEMBL
MHTEQSDNSELLLAEWQELVNLTSSDAHELLRDLCEEELRQLVSVFYDYMLQDKKASLYL
NTQQVADQLSESMYHWLRSVLGSAKESLSALMERQQKVGVIHSRIGIPTDLVARGARKLK
NELFRLLSRKKNLDAALINQAVCFSSLVMDTAIEAMTTAYSPGYKSAMRDQERYRILSIY
DDVNVERERQLGALMNWENQFIYNVATGLPSEEIILLEKSEFGLWFFHKGRHLFNGPDLL
RKLEALIQQVDNRVRDTFPRHVEDTAIRTQLLRDVRQLIGQVNSILCSMFDELIKFENGK
DPLTNLLNRRFIPTIMRREIALAISSGKPFILAMIDIDHFKQINDNYGHETGNLTLKTIS
TKIYESVRSSDYVFRYGGEEFMVLLVETQAPQAAMIFDSIRQLVAGLNIRATEERAFSVT
ISAGIAEFDNHPDYQQLIEKADSALYQAKANGRNRIEIFH
>A0A174N5V6|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MNKKTNVKVDYLYKVLLLCSVLVFLYVFYSIFHIEHMPDSRFIPDPPVSLSEGWYTLDAS
GGKTTLPELNTWSIKSDAPVTIRRELPPLSDKDYLFIENNFNYIKVFVDGTCIYDYSDDT
VDLPANMSGHFICQIPLDRDFSGRTLSVEITQPHTFLSVGIKDISIGTASSYITKYLYSH
AELIISLFIMLLASLCLFSAFLWQKYRKLDYNYSVFGELSLLTLISALWIFTDSQLPQLF
WGNTVAVCVLSFFSFMVLPLPMLSITSTLCQDSRRVLARMKCVLILNATVQGILYSLGNV
SLVLMLPITHSLIVLNGIVLLLFLLHRLKGSSSHFAKPMLLSLILLILSAVLALIQFYIN
PQADNSRFYRYGFILFISILIYVSVKAMLGFVNDYTEHKILKKLAYTDILTNVGSRLAFE
EFMNELRSRTTPFPGVFYVCDLNNLKVTNDTYGHKAGDIILKEAARCMSKIFQDSGKVFR
IGGDEFAAFIQAPFHELPDYVSMLEKEIESADSSCEYNFSLSIGWNASDTIIGNEIDRVF
RQADDDMYKSKMKYRKENSIKSIRDQ
>A0A1C3IYH2|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MLDMKREEWLSTLIRELPDRHLLLDTSGRIVENFDNPNHHTVSELLPLAVEKQLLEAAKQ
AYSSREIQYIQYSLAPCQQLQLSIEQLFAQGEESAESDDRYFESTLKPLYLSPEKQYVLW
QERDITKAQQREAELIELAEIDELTGILNRRAFLLGLEKEFSQSPKQSLTCLMIDIDHFK
EINDQVGHLSGDEVIVQVASLCQQSIDCDDYLGRLGGEEFGVILTHTSAIEAYYVAETIR
KTIESTPCTVDGHIIYPTVSIGVAEYTPHLKTIKELLAQADRAMYSSKQTGRNQVTLYHN
NLPTLKIDAQLRAKILQAS
>A0A2X2S1I2|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHFPVTRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKHQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISRFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGKRHSPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>A0A241QAW5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSTTELHSLDLLTFPVWIVLPHTEELVFANNVARELMQGLCFSPLRKGTFSTHAQNDLTM
YLSDLRNHHHVVEILTVYRDGEEIAMASRLSIRPLPGMGEVILFEGIETPTAQGLKASRS
ATYQRKKQGFYARFFQTNSAPMLLIDPSRDGLIVDANLSALNFYGYTHDVMCQKHTWEIN
MLGRHILPVMHEIAHLPGGHKPLHFVHKLADGTSRHVQTYAGPIEIYGNKLMLCIIHDIT
EQKRLEQELERAALRDVLTGLLNRRHFYQVTEPEQTHAISLTQDYSLLLIDTDRFKSIND
LFGHLKGDEVLCALARTLESCARKDDLIFRWGGEEFVLLLPRTSLDVALNLAEVIRATVA
KVTLPGLPRFTVSIGVARHETNESIDELFKRVDDALYKAKNEGRNRVLAA
>A0A7H9FPC1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLALLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETYQE
>A0A7G9IJU7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFIWEGRLHRIGASAGITLIDEKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEEQAFRAGLVDPALSKALDRRVFSEFFQNSAQAVASKGLSIALPLSAVGLLNTELI
DELLEHLQRSPLPPRLLHLTIPASVIKTNPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGVDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A7W2ZZ70|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGMWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNSRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A514ET15|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MSDFILARVSQTLATEHSLEMLVRQLLEMLELVTRMESTYLTRIDLAAQRQQVLYAHNSS
EMQIPEGFSVPWNESLCKRAIDENCRFSNDVNSRWQSCIAAQELGIITFFSIPVRLADGS
LYGTLCATSRHKQPYNLEATQVMELFANLISHYVEKETLVARLRAANVALEMHSCTDELT
GLANRRALFKHLSAMFPREREQQRNILLIFIDLDDFKTINDRFGHQCGDHFLIQIGERLN
AHIRPGDLVGRLGGDEFLVVGHGLDRGQQQTFIATLREALRGIYCVGEQRINYPGASFGV
AEVNPQVQDVESALRAADDAMYQDKKSRRRNSFLNID
>A0A449BK04|diguanylate cyclase|EC 2.7.7.65|Acholeplasma hippikon|TrEMBL
MKTFKLARKTKEGFSVILVDLDDFKMINDTMGHHIGDEALKMTAYLLRTSIPQTDFVARF
GGVEFYIISESDTDDKVHELIQKIEYNFELHNSYSQSFKLSPSIGYTLVEAESTKTVHGL
QELVDVEMYKNKMTRKERNKLTIRSN
>A0A449BIN9|diguanylate cyclase|EC 2.7.7.65|Acholeplasma hippikon|TrEMBL
MKSLHTLMQIFSSFDEAIYIVDKNRKILYFNPIAERITGFSKDELVGKYCQNDTLNHVDN
QGTKLCIKDCPLVTAIRKNIVMEHQIYLHHKEGHRVPVKVKTIPYVEDNETVGGIEVFSL
VNKEKFEETYQLAKEKLNYIDPLTKVFNRYFLEELINGNYPINVYDYDILFIDADDFKQV
NDQFGHLVGDELLSIISKTINLYLDENEYVIRFGGDEFIVLIKKSDKTPERSETIKNLIN
QSSLRNFKFYPSVSIGVYITKPNNHLKEALNNADKALYVSKSMGKNRIHIYK
>K9H2Z3|diguanylate cyclase|EC 2.7.7.65|Caenispirillum salinarum AK4|TrEMBL
MPNADGGASGAGAGAVSSHMTEGGSGSRAVEANATAVRALSNLWRDTSPALRDRVAACAR
DDAGALADVFYDTLLNDPKAATYLSHDLVRTRLRASMARWIAEVFSVRDEDDMRTLVERN
FHVGAVHARVDIPLTLITLGMRVIKRDMARRLMRNETTLPPEQTGDAILFLGDVLDTLAD
NMHEAYLSDMVGNVRQRQSLKMHMSGESLALEGERLKASLFDWLRSVMVALYDDEVQAAV
LPPLETSDFGLWLNHKADLAFGGMRELDVLREMVAAITRRIAEARAGNHPTIDLIRQLDR
DVTEVAFLLSSVTTHAVELETGRDSLTRLLTRRFLPSILQREVAMSMRHGRPFAVMLVDG
DHFKAINDTYGHDGGDRVLVSLAETLSGCVRAGDFAFRYGGEEFLLVLAEMNASTLAAKA
EAIRREVEARPIDVGDGVKIRVTISVGAALHDGHPDYQRVIKAADDALYAAKDGGRNAVR
VAPPPT
>A0A6N2T3A7|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MPKQLVLMAAVAVSYFFYHYEFFSFADCVLECREKRRSVVILTFVLNYAWFVAASFLDLH
LIVNWTIFFFFFLLQIRIFYHVGFDKSAMLAYFGIIPGLAWNICLRCIFALLLNRPLTSF
DNQTKLPGNIKEYPIFLGFVITGFLFYFFRQSQLYERLCIILRDRSSLRFHVGIQFVLYV
YLVLNLLGYYVPSNSVFLKFWGIKSAVFAFIGLNICIVYTMRMSRLNLYRRKMREEWTTM
LTDKEEEERLWTLAYVDALTGCYNRHLAGQVLEKYSAASKDYCLCFVDLDHLKTANDKFG
HQEGDRYLKTTASVLTAAARDEDYVFRYGGDEFLLLFSEKNRSQVTDLLKDTGEKLKQYS
SDKNFPFIMSISFGVAQCSEAETAEELLSLADRRMYEQKRGKDRRKR
>A0A2Z5K4W6|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. Go-475|TrEMBL
MSTLAALLPVLPPVIGWAVHARWLHSQLTIARRDPLTGLWTRDAFTRRARRLLRDPRAVV
VLADVDHFKQINDTHGHAAGDVLLATIAARLSYGTPGGVVGRLGGDEFAAVVVDRDGTAG
DRLDVLARVLARPVDTAPEVHTTVSLGWVRAADHPGEDLSALLRRADEAMYTAKRSGRSG
RSAPRRARLGRLLESVAGRRPGRRGAA
>A0A7U2ZQ38|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVSPLFTVVRFTLPCALIVTCSGLLLLW
HWKWPQSKINIPAISLLFGMLWAWHVVAKSMLLTPPHFNYLVIALLSILFIGTIAFANNI
TAFTLHSLPTFLACLIMAEGEQWLRMTYCFMLPIAGITLQNIIQRRSDAFTQGLMDKLMQ
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSKETAWQAAERIRQRVYDLKIPHM
FNESVATNVTISIGLTPLIDDNIEQALARADGALYEAKNKGRNIILAS
>A0A2M9E5M1|diguanylate cyclase|EC 2.7.7.65|Xanthomonadaceae bacterium NML91-0213|TrEMBL
MDDLTPAPASQTAVETPADGQRREEWQRRLTAVQAPTRALLAAVVDAGGPELADHFYGGM
LADPRAARFLDPDQVRERLKPTLRRWLAQLLSAAPEDADTLQAVQEHVGHVHARIGIPVD
LVSRGARMVKDRLHRGIRTMAADHTLALDAIVAADALIDTALEAMTRAYTRSREAARDLD
GSFRLFSLIQNVGTERERQRALLLAWENTLLYALTADDPGPAQPLLISRSEFGLWFLHKG
LASFGDTAETREVNQLAERIDTALRERLPAATDTAARRALLDEVRGWADAIRSLVGIMFE
GIGDLESGRDALTRLLNRRFLPTILRREVALQANTGRQFAVLMLDLDHFKSINDRHGHEA
GDRALQHVAALLVENTRGSDYLFRYGGEEFVIVLGSVSRAEAVAIAEGLRAAIASSPLVL
ADATRLPLSASIGVAIQDDHPDYERVLARADAAMYQAKRGGRDRVVVAGHSMPDAPDQLA
LRR
>A0A8B6IQ74|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MLFRRGIGRFGARMLFKELAVFDVLSTPIWVVHPFNESVVYANQASRALSGEMSLTEMRN
GIYSTCPETQLQHYLRYLDTMTEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAV
KLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPQKDGRIVDANIAALRFYHYS
DEEMRNKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGSLRHVQTYAGPVVLY
NIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFYRLVEAPTFIARGYCLLLID
IDHFKNINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIARALIL
AEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFES
VELLHSRGGAA
>A0A087VTR3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium indicum LMG 11587 = DSM 20214|TrEMBL
MARILAVDDEESILDIIRIGLGKEGHQVSTVSDPRKVDMLHLDYFDLVLLDIMMPGMDGF
ELVRRLREATGVPIIFLTARTDQADVVRGLGLGADDYLTKPFHLDELRARVDAHLRREGR
ARSQVLTLGEFRFDMSAKELTCGDRAMNLTPTEYAICEFLAVNRGHVYSKEQIHREVSGL
DPRGEAAAVATHIGNIRAKFQEVGMAPIHTRWGVGYLWV
>A0A750HVZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSAHSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8E9ZGP7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELVDRNMYQAKHRRTERSLN
>A0A1V5F8P0|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MESAPASGDAHPLRVVALIYLCGALLFGTLLVLEWRLIDRSVVAIARERGAALFSLIQTT
REWNARHGGVYVVVDESTQPNPWLKHPARDLQTTDGVRLTMVNPAYMTRQIADLALHAEG
ARLHLTSLKPIRPENRPDAWEAMALARFEAGETEVLALVEGGGEGGSGPAHRYMAPLLVR
EPCLQCHAAQGYQVGDIRGGISVTMPAEVLIARRDQLRMRAVFVYLLAGLLAAGLMHGLL
RANRRHVVQVRRINAEQERLIERRTVELAEANRRLAGEVDLHRRSEQRLAASESRYRAIF
DSAAEGIMLLDAALRIVQVNPAFCEITGYAAEEVLGRKPSMLGSGRHDRAFFRELLATLA
AAGRWQGEVWNRRKDGDLYVQWMSAVRIGEADAPEGFVATMTDITSRKQTEEKLRFRANH
DALTGLPNRRLFEDRLQSAIASALRHGERFALMLVDLDRFKGVNDRFGHLAGDALLVEVG
RRLELCVRASDTVARLGGDEFAVILGEVGGREDAAEVAERICAAMALPFELGEGVAHIGA
SVGIALGPQDDADAGELQRRADAALYAVKHDGRGGFRFHGELA
>A0A633ID02|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A157SJM3|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MKVLSPERGLADLPGALLQQAIEQSFNAVVITDAGRGAQGPLVVYCNPAFSAMTGYCRDE
WIGRSPKILQGPLSDRGVIGRLREALDAAADFHGATFNYRKDGSCYLVEWNVSPVRCSEG
AVTHFVSVQRDITERALAEQQQALLAQALNVTHDAVFIADGDGRIQFENAAFQRWAEQAG
SGPLVRLSDPDCPPFYRNLLMVIQGARPGRFTFSLQAADGGARHLEQTVWVMEASGSGPR
RHYVSVLRDITHFVEREAFLSALARQDALTGVLSRRGADEALRRIRQAPDGGGQPLAVIL
ADVDDFKCINDGFGHPVGDAVLKHCAKEIGRHVRAGDSVIRWGGEEFLVLAPVCALPEAA
AMAERIRKAVRAVGEPAISLSLGVAVQRRHETFEQALHRADEALYRAKAQGKNRVALSTA
>A0A5U3XU02|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARLARSAAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQ
TANTLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6W0BHR3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHLGSVAN
VLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDKRRTLP
LYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRSGFYLS
TLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLPLD
HDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTANTLNDR
ERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISIALTLL
WVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYRE
ARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVL
PGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLADK
RLYYAKQSGRNRICASDATQEREKK
>A0A5U7QDK3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNNL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A758EFY9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMYEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T3RTX0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVAEEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A069RIR1|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium litorale DSM 5388|TrEMBL
MPVKHLMKLVAITIVIFIISALVFANNMKTQSEYEFKQTGELLTTEISDMMELWTQDQLR
ILAGIATNEYVIDMCLDPQDPLKVEKCENFLKELHSRYPYYENLPVAVNLESPVNRAING
SSISVDYGEFLVDTVAGETIGKGGPQYSYIKEVFAGKPYYISEIYPSILRGTPICVMSMP
IVHDSSIIGIAIISPQMHYFTKMFVDNAKLGSTGYMFLLDENSKIIAHPNRDFILSDDAD
TLEKSSFIISQIQNKNNFFKASLLERSKHYYGKAISLGDGNVKDKWYIVFSQETAEVHSD
VYDFLKLMALIAIMSTALFVGCVAIVADINKKEQSKLQLIEMNSKLELLVEERTSELRIL
AYTDGLTQLYNHRHSYDLLNKIIEDAQKSSSQIVVLLADLDKFKIVNDVYGHPVGDMVLK
ECADAIRQNIRANDIAGRYGGEEFLIILPDCTFESGEKIAERIRKSIEDKEFDIKGLRIT
ISMGLTMWNGQNSSELVSSADELLYKAKNNGRNRVEIDPSIISLFAKNKLSDSQPGI
>A0A2S5CX10|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MTDHLQTLKYIKSDVLSIWVSSNGGLVSFNEYFYSFKQCLKKHLKIENAAFLSFEGNSLI
PVEELASLTIETKLNAVSWLMIEASFYQQKVVKLPYILKEKTAYNMMTDMVLFQTEGKEP
MGVLLVEATDTWTDFMTSDYGEECVETLTKVLQMLIENLEVKLNEDQYRKLYNMTDLFHS
TMDIDLILENVLKNIRDNFPEFNVELILSNDQDRHTTIDIKLFDYLSERPATIEAFVSGE
LTTELAGDLNCRLLNAPIKGRQAIYGILQVSAPTTYLFSATEKDFVRMLAQASGNALENA
KLYHQSHRLVSDLQLINETSHRLNMRIDINEMLLFLQKQLMKSFQPMEVCFAFKDHATYE
VTDASTSLFKSEEGNTYIRHVEQHFEHTNDPLFIADFSRLTPNQIEYRSIMAIPILMEEK
INGFSIVLHKEPYFFSFDSFKLMQSLIHHSSLAIANSILRNQLQEMVDRDHLTKLYARSY
LDQYVEKSLKKDQSGMFLLIDIDNFKRINDTYGHQTGDKILVQIAVKLEETIGASGICAR
WGGEEMSVYVPNVGEQEAIELASTIVEVIPNATDPKVTISAGLITWDQYYRPAFQAVFLH
ADTALYEAKNNGKNRFCIHDRTLQTNA
>A0A378Y9I9|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MLDALQSLLATVQRNERSLKRFQDIELALMGAPDFGQFLEVVLNRLRHDFDLSGVHLMLA
EVDDTLRDLIDTAEGIRALDSGLCIAQDAGTFSAVCGDGQLWIGAPRERHAPLFGARIPA
SAVIMPLARNGRHLGVIALGSRDARRFTAEMATDFIERFGAVVAVCLENMWNRERLKRIG
LTDPLTGLSNRRYFDQRLREEVVRGARYGAPLACLLIDIDHFKRVNDSYGHATGDRALRA
ASACMRAQLRVTDTLARYGGEEFAALLVQTEQNWAGTVAERVRRAVARLEVPDDGGTPVP
LTISIGLASVHPRDMTDHDTLPMRLLGAADAALYAAKRSGRDRVVVAPAASLL
>A0A380F7M6|diguanylate cyclase|EC 2.7.7.65|Staphylococcus carnosus|TrEMBL
MIEAIIYNISVTVAGIYLFHRLQYSETKQMKFSQTYVTILMTVVALLLAAYPIPVHDYLL
FLTFVPLLFLGRYTNVFFTMVSAAIIFIVDVFVYGDPLAYNIALLIIALAVSVIGPFIKQ
NDIVSLQILNAISLIILSIISIITKLYTLQEIIYLIPISFVVTIASSITFVDIWRFFTLV
QRYESEDRYDYLTGLGNVKEFDRYLNKMTDEADEKSTSLGLLLIDIDGFKDVNDAFTHRS
GDAVLKQISQLLINYVPPNVRIFRNGGEEFSVVVLGYSLDQSVKLAESIRAGVEQSTFHL
PDKEVIKLSVSIGIGYLTADDYKSQRKVFKDADDMLHMAKNEGRNQVMFNPIVKS
>A0A2S0XQT7|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MLKIMLKACSVTVAVVAVSQVVSFATRYAAGQPFTLFVFLMNSILPVLTAFPAGLYVFWQ
TARLKRALAELRELHVKLEAKANRDQMTGFLNREAFFEQFKMARRWTDTGALALIDADHF
KKINDTYGHLVGDEALKLIAGAIDRTTRELDIVGRIGGEEFCVFLPAASRDDAVQIAERI
RIEVERLVFQPDDGKHYPLTISIGVALTRGHHLTSQLMRQADRCLYDAKGRGRNTVVVED
ALAEMAERKTSETG
>A0A2S0XFZ1|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MSVTEAKSRLAAPNAAQRIPGILIVGGVIFAAALFGILTRPVGFLASFWPANAILLGMMV
RNPRFAGPAGWAAAFVGYVAADILTGGGWYVTAWLTAANMVSAITGYLLFRLVSENDRKL
QHPVSVLYLFGICCMAAVAAAFAGGGAVGLLFDRTFAVGFKLWFVTELVNTLVILPAILT
FPGVRSLSVRWPPSDGLSLETMLRGAPCLALILSVAGGVLIGGPGALAFPIPALLWCALT
YSLFTTSVMTLLLCIWLLISIPAGLVDLAAPADPIRSLDSIRLGIALMALGPLTVASINT
GRRELIARLQHIANYDALTGALSRGAFFERGQSRLDELIQGHGNIAVLMIDLDHFKRVND
EHGHGVGDAALKAFFPQASKHLRAGDLIGRLGGEEFAVLMPLADMIEATALAERIRLAVE
ATEVALPSGEALKFTVSIGVSAHKADASTSIDAMLAAADQALYEAKAGGRNQVRVRS
>A0A6S7DUN2|diguanylate cyclase|EC 2.7.7.65|Achromobacter ruhlandii|TrEMBL
MDPILAELSASLQAAKSVEQLTRPLLDMLGAVTGLESTYLTSIDLDADLQHVRYARNAGT
LQIAEGLSVPWADTLCKRALAEGRLATSDVGACWPDSDAARQLGIQTYVSAPIRTDDGLL
VGTLCGASASQRAIAPQAESILRLFSNVIANFIEREQLVAQLRDANAKLMAFALTDPLTG
LPNRRALYEELDRLRGRALREGGSVLVGMVDLDGFKGINDTHGHQQGDVFLREIARRLAM
ALRASDMVGRLGGDEFVLIGPGPALARGDAAPGHEAERGDAEEAARSLEDRATAATVGRF
QLGDAALAYEGASVGVVALDPRGLTAEEAVRLADARMYEVKRARKGSRTIH
>A0A2M9GYC8|diguanylate cyclase|EC 2.7.7.65|Achromobacter ruhlandii|TrEMBL
MTTSLFFLVWGLATALALPLLLPFHARGGVPGIQAFTAANALAVLSLLAYASSEIMPPGA
YVMVSNAAWLAAVSAVYVGVRQFFGLRPHAVRAAALTVLGIAAMALMLYGVDNLVGRMTL
FSAYTAVLMAATAAVAYRERKRIQTPGVMLYVLLSLFSLIALHLLRVGVYGGGWVQTSSL
LDPAPWGLFFIVCGSVTVPALFLALLLLIQTSLSEQMQAALTFDSLTGAHSRRSILDELE
HELRRCARSQGRLAVLVLDIDHFKSINDRHGHATGDMALRHFAQVVPKAVRASDRFGRLG
GEEFVLLMYDCDAARALVQAQRVCDALRDSPMYLQGQELRMTASGGVATFQPGDTADGIL
ARADLALYKAKELGRDRVEMAWSGRAPGRPQAAREEAADLAAGA
>A0A087BTG0|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium mongoliense DSM 21395|TrEMBL
MTRLLIVEDEESYREPLVYQLTREGYAVSAAATGEEAWEIFTRGGIDLVLLDVMLPGIGG
IELCRRMREQSRLPIIMVTAKSTEIDTVVGLEIGADDYVTKPYSFRELLARIRAVLRRNP
GAESRDAGDTHEDPLLRCGEVIMNVAEHEVSVRGEQVFFPLKEFELLEYLLRNKGRVMTR
HQLINHVWGSDYVGDTKTLDVHVKRLRAKIEADAAVHRYLTTVRGLGYKIDDPR
>A0A290HQN1|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MKLYNKILILTITQLLAIFIFGIYQIQTLYLTQQKAFDHKTLIQTEMVQTRFEEMLQNLQ
KSAKILMNSQEVTTGIISNDTDLLFNWGKLFLSSPSDKIHFMNLKGTVISRGEAEYSFGD
DVSKTFYFQQVLHNDTFLGIDIIDNQECLVFASRIKQYGKKPIGIICVAIAIDQALLNKM
VEGTNMSITYHSAYQDISTTHSQKLFNISTLHVSLQTLGVQEATFHIGLTSEEELSALKE
TRTNFLLSIALAFVLLFIALHIVLLKHLKDYENLTHLLIDFYEDHISIKEVITRTQKVIF
DHTAPEVKKIAEALFKMSQKIADTQDELEALSTTDQLTSLANRRKLEECLNQKLKEANRG
VHFSIIMLDIDRFKTINDTYGHEIGDHVLLHLSHTMYHAMRVSDIVGRWGGEEFLLILPE
TSLQGAIVLAEGLCAKIAELHFEHYPQSVTISLGVATYHEDDTSNTILNRADTALYKAKN
SGRNRVEYED
>A0A5M9ISB0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MSLQAVRPKILGFISEQASAWLVALVVLLAGCTLTTIVAWAASDLDQQQERQRFQLLVNE
RFSRLQERFEDQEQRLGSLRRFFVNSDEVSREEFEGFAQPLLQRARAYAWAPRVSRDQRK
LFEQQVSRQRGTPFNIRELNANGELAPAAERDEYVPVLYSQTLSLLVSPLGFDLLAQPLR
RSALERAQKSGKLAVSQPMQLVGVEPAYATGVLLVAPVTAHGATEPHGFVMAVISMRQLV
AEGLPRPDRDNLAMQIVDTSDLQQRLLYESGSARVDSDLSAVRRLTLGDHVYALSLRPSE
MFEQANHSSLVLILAMGGLLSLLLSALLYVLVSQRQRALKLVQQRTMQLRAREQELRGAH
GQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFKAEQVLGRSTLESLHVPAELEAR
ATSLSVALGKRIPPSQAMLVESPDSQHEASEWTLVRENGSQLTVNMLGTVLLDDHGLWVG
YLAIYLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPQDNWRFIYASDGMRDIY
EIETGVLQQDAKKVIERIHPQDVERVRASIRLSALQLTHWREEYRVQLPQRGLRWIRGEA
TPEELPAGGTLWHGYVSDITDLKRVEEELRTLSITDSLTGIHNRRYFQDRLKTEMLRLNR
TAGALSVIMLDIDHFKRINDQHGHGVGDGVLQELCKRIGQRLRRTDVFCRLGGEEFMVLC
PNTDGEQAYRLAMELWQSLRSAPMEPVGIVTASFGVASWRVDEGIDGLLLRADSAVYVAK
QAGRDRVAAEEVQA
>A0A653AV79|diguanylate cyclase|EC 2.7.7.65|Clostridium neonatale|TrEMBL
MEVCASINILNIKGYVYDKININDIKIIVDKNNSIKIKLKNILQNELKKMNLYSSPMNLK
LFPYSLYNRDEFSNELNNMNEIINLFNEIFSEEDLNSDLTEIKEIKKFFGYIKTLNKMCT
ITDFIKYVNNRLKAEYTVFIESGINKPKFNLDIIGREEELNIIEKKFNNILENKDKYNII
CFKGENGTGKTKILNEIEYIISNKYLKQILYIKNLEDINLSVEELEACFINFFDGILEKI
TREKYEYYIKRFMEILIKNKSEIDDNEKLKIANRIVKCISEYSAKNPIVILIDNLEEKLE
IIKLLLKYILLLDRNTENIMVVFTVNNSYCDEEVSLLLKQLEKLEKYEEYTINYFNQYNT
TKMIKNILNYSKEIDKLSMEIFAKTLGNPQYIISLIEELYNNNYICFDFKSGVWKIDKEF
KSIAIPEKIDSKVNFMIASLRESEIHILKKLSIFLTPLPERIILKHVITGEEGIEAYNKL
KEKNFLADKIGDKGLLVGFTNELLKNILYSKIDKKTKYVMHKNATEFLEEEIYNDDSYVE
EFLYNLEKIEEFNKLYFYTIRCAQVEKIYGNPSKSIQYYKKTLKYSDDKNKCNIAINIAK
LYECISDHENGLKYFKLANEYSFKRSKKDMQIYTNIEIIIIKMNNFNECNQDIILLLQNI
RKQLDEINYPKGEVYYYYALMLKARIEEEYEMILEYGSKVLEILDEFRIKDDVHGWILNT
IALEYRRIGIYKQAKKLIFNSTRLFENNKNMNGYIFSKNIYTELLKEEGRPIEKIIDNLI
EISRLSNRNKLYKREIFSLINIAICYLNIDNYVEAERYITKTLERQRDESVEFYSDIIYS
TFCLLQIKLGNIRLAVKYHTLYQMFLNNTKNPEENMIDNSISSYYYNLIFYNYDEAHEIL
RKIYNKISNKNDYKSRYIVCNYYQMLLLKCENELDVKNIYNILKNKLEYINNINKQIEIK
LKAIRFILKLDYRTLANKLFNEIKDYPNNYNMEAYYIYLELYFKDNNSHYNYLINKGLRV
CSLSVEKEIKRDLYAIIGEKYSEMECYKLAFYYYYESISLHVETLKELPVKEQLIYINKS
NFFYVYRLLVECLNDKLKIRINFKDFHNINNENELNDILNEIKITRLLNNQSIYNLTQGL
YERLYYNNLNNAYDLFFTFNEDIIKNLGSIVKYISKITLSNKALLLIENENGENEVVYSY
RINNVNTVKSYFNNKIESQDNVLILSENDIYFNNLEIESMKIKGCMYIRIRNEETYLNGS
NKINGKLILLSDNAINNINDSSKILVEKLVPFIKFMLEKYNLTISSTLDKLTGAYNRRYF
EQALTRLLDNEKATNNIFGIIMFDIDDFKGVNDKYGHQTGDEVLVKVVKEVKKSIYKNNI
IGRYGGEEFLILIPNADEEKMINLAETIRENIEKAKILGEKRPITVSIGSAIGGNEVLSS
RDIISRVDRALYKSKNAGKNKVTFWRKEFDENIEDVDINGGMISEMLRSHNLDLVISDIV
NLMKYNITKKERIHQFSLKIINTIKCATIGVFLIEDYKINSTFVTRLNGEFSSDLENFNL
NFVDKVIGDGKSIYNIDWNNGKKYEGNSIPEWKSVCLTPVISNGKIIVVLYLYDSINNKE
FDNNDCILLNSIAQLSIPVFL
>A0A5M9IRH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MENRRGKGLSFAKRIYKPRIIGLGIGCISVIGALYPLTMPGWVWAFLLFNGFAWAHVAYQ
LSTRSQFPYQAEQRNLLYDSLSGGFWAAATQFTPLTAVTILSMMTMNNVAAGGLRLFLRG
LLAQGAGACVAWALFGIRFNPDVSLLQVYTCLPMLTLYPMAIGMVCYQLAIKLAEHKRAL
SALSRTDSLTGLLNHGSWKDLLHLKFHKCQLQQSHATIALIDIDHFKQINDTHGHIIGDA
VLRQLGLELRRHLRENDLAGRYGGDEFCVILPQMSLNEAAKVMEHMRETFSRYQNPLIPE
LRVSLSIGLADFQPLFTDAAMWLNAADRALYTAKDTGRNRVNVSNYLIAHSA
>A0A1V6H2H9|diguanylate cyclase|EC 2.7.7.65|Thermotogae bacterium ADurb.Bin062|TrEMBL
MREISFQSMINTLDLFSTGVAIVDQEGRFLFWNSGASLITGHTAQKIVGKTFDEAMTMID
VFGQKISFEYFLEMHCLRGNAASLEVWIETPEGLLTHMRLYSARLTDGEGTCLGFAMILH
DVIIEEVLGDALEKVAEQAHIDALTKLYNKETLLEDLRTHIENVKRAKYQIGIVFMDIDR
FKSINDRFGHITGDSVLSLFGKCILSSIRKGERAYRFGGDEFVVLLIIDSEEDLLRFTQR
FEREVYETKFPVTLNVTIGFTVVLGTDSARSALERADQRMYEKKIGKTHTETKTP
>A0A5M9J267|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MNGLGRTQDEDCFIEEQVRTDRLHQLFRQSFAAIFGSYFAAVMLCWVCWDRFDHRVMTVW
LLVLAASSLLRVKMFMDWFRCPGSERTPDRWERRYWITLCLSAGVWGVGAFAVMPTDDRL
SQTLVILFTVGMSVSAVSCYSAYRYMTMASVGLVLLPSTLWLLFQPSPMQVGMALAVLVF
SSFVVSATRKMSDALEKAFRLTREMERAHTISTHAAQTDELTGLMNRRAFFEHAQQLYAQ
CRYHQQPLCALMLDMDHFKQINDTYGHQAGDQVLRQIGGVISASFRQADVYGRLGGEEFA
VLLPNTSLETALDIAEQLIKAIAGLASDPVQGLTASLGVASTHNQDQDLHGLMNTADKAL
YRAKALGRNQVAVAE
>A0A0F0CLS3|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MRSAMWRRVDIQVSVFTAVIVALLSYSIFMVQYKITYRDMLRSLNDQAEHIYTYIGERFE
PDTFKHISTREDVLKENYTRMHDRFQRVREITGVMYLYTAKMDENGEFVYVIDCLDPGAE
DFRYPGDPIEREIYPDMERAMQGEIVMPEEIKKTDWGKIFITYMPIYEGDEVIGVIGIEF
RADHQYRTYQNLRRALPVFILLFSLIACLVSRFLFRRISNPFYRDMSNMDYLTQLKNRNA
YQLDMNNLEAKKMESGIGFILIDLNSLKHINDTLGHDVGDRYITCISKAYLNMHTGEGVM
YRIGGDEFVVMMPKATQAGIEDFVARLKKEFDKLAFRPEFTFSWGSAIFDEEADDNLFST
CRRADKNMYMKKQKYYEDKKT
>A0A0F0CLM0|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MSVKNNILLRTNIFVCTIIILGFAVTSITSYRANIGVFEKDVEDVTDLASEGIYYKIDSI
FTKPVNVSLTMANDSLLKEFLAEEQSRMEDETFIKSMRDYLYAYREKYAYDSVFLVSAQT
GRYYHFNGLDRVLEQGNPENTWYYDFIADPHEYSLNIDNDEAGDNEITIFINCKIKDRDG
TVMGVVGVGFRVDYLQELLKSYEDEFNVRARLADENGVVEISTHHTSYEPVNLFDDGSYD
DMRDQLLSGREEMQTFWHTADRSRGYMVSRYIENLDWYLLVENDTTDLNRHMKESLEQGI
AVILMIVAGVLFTITTVIRRYNAQIIELTTAREREYNKIRQDAAKELYENIYELDITHNC
AVGENTERYFESLGVPVKTPYSEALNIIADKQIKEEYRRGYVDTFSPEHVMEAYSQGVKS
LTYDFMITNNGSDYYWMRIMACIYFWSEDNSVRMTIYRQNIDEVKRQETKLFEQMQSDPL
TGLYNKAATEEMISEQVKGAEPGSSYAFLILDIDNFKHVNDTLGHSAGDFVISQFAQNIQ
SHFREGDIVGRIGGDEFAVFIPFTGMESLEKKVQQLVADLHTCITTEAGKCNVSASVGIA
IYPGSGMDFETLYKNADLALYKTKKREKNGYTVFKK
>A0A5N7ZTR4|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MSSSSLGFPSSPGQSEGLPGPACYLTASNEQAWEAVYRSVDAYTRGQVAAVVADSVGQLV
DTFYSVLLADAEAGPRLSHEIVASRLHSGMTRWLKGLLCVRDQGDIGALMATQKKVGEVH
ARVHIPMHLVMTGARILKNEIAMRLRASDLDGIAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPALLQITEAVARLDQEVLPQLMRDEAQGQASSMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSEFSVLLLDIDHFK
AINDEHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAGRDAALAAAQKLG
AEIRRHVFSIAEAGPQHITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSEAA
>A0A3C1XW47|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MEASALAATTKAATGQDCYLSASNAHAWEAVYQSVDADTRGQVAAVVSDHATQLVDAFYS
TLLADAEAGPRLSHEIVSTRLHRGMMHWLKDLLCVRDQGDIDVLLATQKKVGEVHARVHI
PIHLVMAGARILKNEIAQRLRASGLDGMAASAATQYVCNLFDLAIEQMSRAFMRDINRGA
RNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLSASEFGLWLQH
KGAVLFESAPALRQITEAVARLDDTVLPRMMQSASQAPESLPNQVRELQELVARIKHLLN
GLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISLAQRQRSSFSVLLLDIDYFKAINDAH
GHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGPALAAAEKLNAEIRRH
RFMIAEAGALQVTASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSVAA
>A0A381E4H5|diguanylate cyclase|EC 2.7.7.65|Campylobacter ureolyticus|TrEMBL
MKKSDEIIKDIQNRNHNYLIMINDFGVSLAKNSLSFFEIQSFFKNLADYAAYQFEDLKQI
FDEFEIDKRQVESHIKNQKIFLNEVNYMCSYVSDDVYKIKPLLNFLIFWSESEVNNQNFL
LFKQVELIKKGMTPSDAYELMSLHDNTTFARTINNFINTLIQKNDELAQNNIALQIKLNK
TTKKLNALNKELDAFPVTDPITNLSNRTQALKALNILFKEENKNVGALLFSLTSYNDMIN
QLGYEVTNNIFLAIIRIIKNSMRSDDLIYSMKKDELLLICQNLNETSAINIANMLIERIT
KNSVLNTLLGSFNKLSINIGIALLKSVSDSDDLLVLLDKKLKNAQSMGKNRIEI
>A0A0M7MRJ4|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MKAGNAELDDRIVGLLADPAYAGHPLREALQDLWRHTAEQMARIERVTHLSDAYQSMAHQ
REMGLCEQFDRQLRRLARIARISDHYQSMMRDLNATLEETSRRDPLTGLLNRRALMEMIK
QEVQRAARGGQAFVVAMLDVDHFKSVNDRYGHEIGDRALVELAGAMRRSVREYDLCGRWG
GEEFLVLLPATPPETAQGVMDRLVGAVRGLAIDVGADVLRLTVSIGMACHQLGETFSETL
SRADQALYLAKQDGRDRVALGFPRP
>A0A8F6L4A4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. WY228|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVSGLGYELGCVNLVRPDGD
LVIAAFAGNAAAEALITGRVGSRESWERRLSMGQAWDQLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASAGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQQGRLLR
TNDALCRLLNRPASVMRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICER
PHSSPAATAIEALDAAYGDVESSLTHGYQADGYEGEVVPGGGPFDHHVHTVAPDPAHDDG
TKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSACVRDGDTVARLGGDEFVVLAD
GLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVE
KRSRSKVHRRAG
>A0A8G0RGV1|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain JCM 10418 / VPI 12708)|TrEMBL
MKKLSVFKIIQLSILAVITLISVFFLLKPEVKQFVFSSSSATTLFFLIWIILIASFLFIL
IDLSIISSIKLHFHNLYGVAYSDPLSGIPNRFSCDTLIEKYIDSELPEDIGCIMIDLANL
PEVNSLYDHAAGNRLLKDFSAILSSSALSLGFVGRNGGNKFLAIFEDCTQEKLDAFLARV
SERVQRHNAKADSIDMEYKAGTALNSEEHLAKITGLIALANNRIYKSS
>A0A378TJK7|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MVMAIRRWWRQPDHFYWMTSLLAARGLQAGVCRVIAATVLGLGAVNVAMLASPRGPQGIT
NQVLVAAVAAVCVVLAALWLRRRWPSRTGSSLFVVIAAAGIAACCLAQHDPTAGLLGCTA
FAALCGYVAFFHQPRLIVFTVAVATVTATVLALRQTADPVFAAAALAFLAMVLITVPAAC
QAMVHLLGINVLASEIDTLTGLPNRDAFYRATGALISARGRVDDRHLVLLVITLDNFSLL
KSAGGTVACERALVAVAQTLRETTRSSAVLGHIGDAEFVIADTFSSTDSSPLVERVRGAV
ATTPPRLTASIGVVSTPLGALAGCPPEELLDELIELAGQSMGDARRGGGNQARYTVCPAP
AAIEPENRSDADEQW
>A0A5I3VC16|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mississippi|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAVEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A653T495|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MPEDQRPDALPSVGESPGQFGFWELDLRDMALTLSDATRVVYGLAPGACRLGELLQHVHP
DERQRVTDTMLATLHAGARLDVGYRIFRANSQERHVRMRAEPLRADHGSVRYLGTVQDVT
EVVRREAEAGLKARLLQMASAVAHVGGWIYDREQDRVIWSDEVCRIHEVPPGTRPTAEEA
IAYFAPESRDRLRRLVETCLREGTPYDEELRLITARGRSVWVRAIGEAVRSALGAVTGLQ
GAFQDINDKRKAEQETARIGALLSDTLESIGDAFYTLDREWRFTYLNREAERLFKRPRAQ
LLGEVLWDEFAALKGQIGYCEFHRALRENRSVVFEEYYAPHQALSEVRAYPTKDGLSVYF
RDVTEARKTEESLRISEQRFRTIARATTDVVWDWNLEDDSLWTSDSIESVFGYTTVDFSG
PIRAWSDHIHPDERERVVKHIKSAIEGGEEQWIDEYHFMRKDGSLALVLDRGYIIRDASG
RALRMIGAMVDMTERRQAERRIEYLAYYDSLTQLPNRQLLMDRLQQAVDDSAQRRHANAL
FFIDLDNFKSLNDTLGHAVGDQMLKQVAQRLSGCVNHDDTIARFGGDEYVVLLQEMSTDM
VEATTQARTVGERMLKSLRQPYKLDQNCHHSTASIGIVLFSGAGDDIGELLKRADMAMYE
AKASGRNTLRFFNPGMQAALSARMALENDLRQAVRQCDAQFELHYQPQIDRHGLVTGVEA
LVRWRHPARGMISPAEFIPLAEETGLVLSLGQWVLKKACGQLLAWAANPATARIEIAVNV
SARQFHHPQFAAQVLDVVAAAGIDARLLKLELTETSLLENLADTIAKMNVLRTHGVSFAL
DDFGTGYSSLAYLRQLPLDMLKIDRSFVLDLLTNQNDAAIARTMIALGRSLGLRVLAEGV
ETVAQRDFLFEHGCDAYQGYLCASALPADAAAAVVCKP
>A0A0N8NTN5|diguanylate cyclase|EC 2.7.7.65|Oxobacter pfennigii|TrEMBL
MNVFNIDMGTLLIVLVLGHILTGILIISYTVRHNKEKSVNIFLLSKLFQSVAWIMLGFKD
AIPYIIWISISNSILFIGAALELIAFLTLVNSYNKAIKRNYNILILICIATFNAITIYST
PENIRIVFASTITVILISFPAYKLFRHKNPSVLQKVIASFYSITMVSFLFRAYMALTSAH
DMTLWSTNIFNTGSFLLLYLVMLVGSIGFILLAKEKLDVELVKAASLDELTDIFNRRTFI
LRAKEFISLFARKKEQISYLLIDIDNFKRINDVYGHYIGDIVLKEFAGAIKAQLRVYDLF
GRYGGEEFAILLPGTNEKDSIEVAERLRKTIENTPVSINPEIKYTISIGAVTLTPDSKTN
VDMLYKISDNALYMAKMQGRNRVVRFQNAV
>A0A0T9TQM5|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSELESLSTLYRDACVTYATLSISYFALSKNSAFSYDGDIWKRIVFGFASGLVSLYLNQD
QWIISGSFFYSFELIPIILVTFYGGWLSGLTALVMNFAFTGWITLDNILITIAFIPLLFS
KVWEKKSNRIFYMTIILIAIYRMIAALLLVPQSLTWTQVMVYQLISVLCLAICYHALNFK
ERHIYAYFSMKNRANTDKLTQLNNRASVDYRLTAIHNSRQACGLMILDLDHFKSVNDTYG
HNGGDILLTAVGKLLMSAIRDEDFVGRYGGEEFIIITHRHEPQAIKAVAERIRQRVEDLT
VELSDGRTIKATISIGASLYLPGMSMLTALKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRTVKEKRRR
>A0A0T9TAB8|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSSIKNKSAGQAKHHNAPTNLPTLGRVLGRIHLIVALVSVVTAGICLTLAALLALRVYVD
HNLHLVARSISYTTEAAVVFGDSMAANEALALIAANEEVDNVKILDVNGRELASWTKPDT
SPMHYLEQQVARCTLPDPVVLPIIHDGNEIGTVVIAGHGSNLLRFLLQGMAGLLLCLVLT
TAVALVLSRRMLSGVIGSLNQITKVAHNVSRHRSFGQRVPSAKTAELNALSDDFNELLGE
LEVWQAHLTQENDSLAHRAAHDSLTGLANRAFFEGRLSRTLGDCEPGEHAAVLFLDGDRF
KEINDNYGHAAGDVVLTTIADRIRALLRESDLVARLGGDEFAVLLAPIHNIKDVSIIASD
IHESMSQPIMLADGCEITMSLSIGIAIYPDHAQTPEALLQRADEAMYQAKKNFQSGGSMI
AQPSDDPLTEI
>A0A2M9N8W1|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM1FR|TrEMBL
MFSTFFINICVMITFMYVSGIIAKFYSIRLPFPSLRVQLIGGLLFGIYGTVLMNYSFPLN
ETTIVDLRHLAIVTAAVYMGGLASVVTGLMISVIRILMFGLSSSAIDAGFVMTLIGLSGV
YFAYAPWSRLTKIITMNLLGMTLIFIILMLNTDSMNSLMKIYPLQMTISFAGGIFIYFIA
EFINKSNEMLFLLEKRASTDHLTNLSNRRQFEKSLQLELQRARDYQQKLSLLAIDIDRFK
KVNDTYGHSAGDAVLKQLGQLLVEHARSADIVSRNGGEEFAILLLDCGHRQAVATAESIR
QAVEKYHFALPDGHTTRLTISIGVAVYPDHCDDHDDDDFFEQADRALYEAKNTGRNRVCA
LTFRSLPLTL
>A0A8B3UUQ5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLF
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAINMAMTDSLTGIPNRRGFYR
AGDKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTGSYLHALSASLDHYNDTSGKPYNINYSFGELINNADQYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A2M9MPG0|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM1FR|TrEMBL
MIAQIKRSRRLRRKIKNIKKISLTALLGGLVTISVIMTLTLMVISSYTSQKQSLIDNTLS
LNYASAVQMSQTLDSLFYSMQESLKYAANYFPDMDHSNTKELNSTLDLVRNSSNFFNSVS
LVDKAGVVRSTSPYSQASVGHHVSSNAAKEAVSLRTSYISEAYQTPRTKRRIVFVSEPIF
DSAGEYQGTIGGNIFLQENNILSLSFGSQLKTSNGSYFFIVDKKGTLLFHPNTNRIGENV
SKNEVVQKLLVNKHGKEQYKNLAGVDSLAGYYKVPSTDWGVVIVSPTQTVYDQLNHHIRM
LLLYTSVPFLILTLIVVRVARKLASPFAMLADLVNQVDKGQVELPVMKPHWNREADLLTR
AVVGALANFRKQTNQLVYDARTDVLTGMNNRRTFEEVIQEWIQDEAPFSIIVLDIDRFKS
INDTFGHHAGDEVLKHIANIIQLSVRPEDVCARFGGEEFVVLLRNSESNVAFEIAERIRI
TVEESVLPIDRSVTISAGIAEYPKHSTTSTELFHLADNALYQAKEEGRNRTVTIQSVIK
>A0A445NDS7|diguanylate cyclase|EC 2.7.7.65|Streptomyces netropsis|TrEMBL
MAGDGECDGRLRAVVELAQAMAAARTPLETVDAAAEGARRALEGTFAAVSAWERARGRLR
VLVNAGERAEGEERFPVDESYPVHDFPEIAEFLHDEWVGGGEPHAWVETAAAPEEAAGGF
GTYGPGRAHGLRRRGRGSCVVAPIVLHGRAWGELYVARPPGVPAFDRADADFATVLAAVA
AAGIAQTERLEEVRKLAFTDPLTGLANRRAVDARLDEAVERHLADGVVVSLVVCDLNGLK
RVNDTLGHAVGDRLLERFGSVLSLCGAKLPGALAARLGGDEFCLLTVGQPADDVVRVAEE
LCLRAAELEFGEGVACGIASTGDPIGDVRSARRLFRLADAAQYRAKAARELKPVVAGREG
GPEDPVVRLADRPPAPPQAERRRFRGRRP
>A0A0M7A0C3|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MTLAQVQIETERLEALRRLALLHSEHLHEFDAAVSNASYLFDCPMAVISIVDAEEIWFKA
AFGLDATETHRENSFCGHTILSDDVLIVPDAQADSRFCDIPLVTGDVGARFYAGCPVIVD
DKHRIGTICVIDTEPRSVSEEQIAQLRNLAKIVEGLIKAHKAGLETREALQEAQLEQDRA
RRNQDLLKEITLVSGVGGWEYDPKTDAMTWTAKTREIHEVGPDIQPNLNTALSFYPSDSR
KALRAAFETAFETGCGWDLELNLVTAGNRQIWVRVVGNPVFEGGSVRRIIGALQDISDSK
RKQEEVRTSEVIQRTTLEALQEGILLVSPSGKIQSSNKAASLLLGYPETTLVGSNVHDLQ
LTFQDVADAGSHRMSPLVLAVTDPGQDLDLEVQLAEAGSGQVRWLRINARPVDENSVHGP
DCVVVSLTDITKVKQQSDTLQGFFDNFPGGLVHYNTQLQLTFWNEEFARLLNLPHDFLDQ
RPNLRQVIRYLADRGDYGPGDPALIAGERLDRYGAGNRHAYERRTSDGKVLEVRGTPLPG
GGSVSSFLDITRRKRMEEQLVEKEQLASNRLFEMEAVIANMRQGVSVFDGEGRITLWNTD
FQKLFGKPDGEIRKGMTLVEMLQLEKERGEFHDDPHAFYAALREKLDAGKVIKTNFKHPN
GTIISIVRTPLPDGGWVGMHEDVTSREKATEEITYAAHHDTLTGLANRTLFNLKLEDAIA
RTEHHDETSDLLMIDLDHFKPVNDTYGHDVGDDLLLQAAVRLNECVRTKDTVARLGGDEF
AIIVRNTAGDRDLASRIAERVVEKLKKPYHINGNILEISASVGIASISGEQVASPILKKA
DLALYAVKNEGRDGYRHFEENAVETD
>A0A822WSY3|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASGADTAERQAIELRQNFDELTENIETDAWKQS
DLARLYVIKKNPQILDEYNASEKKLKSIELKLEKLQDTGASDDELALLHDGLKIIDALQD
EQQEALTSAARGEDAQAVALLYGMPYEQELERAQTQIDRFRQILDKRVIASVREATKKSK
ALRTASEVMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDFAVETPNFNQIDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFDDVINVAELFAP
NIAPGIAGRLYVFDRDPWQMRCVAQWLSPADDEATFHPDACWAVRRGQSHPPVNGEPDVA
CYHLPESQAESALCVPLIAQGEAIGLLSFQNITPENAPARAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLHTQMTQAMRNGEPLSCMMIDIDHFKSINDRFGHEA
GDQVIKNVATIVQRAAHDGGLAFRYGGEEFLVLLPGAGEAEAHACAQKIYNGVHTLSLRY
GLTEIGPVDVSIGIASYPEHAQSDNLLRAADVALYRAKELGRSRIVSFGMLEAG
>A0A080IY35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1-250-04_S3_C2|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLGNEQ
VERQLKSAMERWIINVLSAQVDDAERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3S4LTW0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MGGGFALGVGIWAMHFVGMLAMDHAMNMRFDPFLTGLSMLIAIGSSLFALWLVSAEKLRL
RRLLPGALVMGLGISAMHYTGMAALQFASIIVWNSAWVALSIIIALLASCGALWLTFRLR
HEGTDVALRRAGAAVLMGIAIAGMHYAGMKAAHFPQNWPMEHRGVDSNWLAVLVSVVALT
ILGITLLVSLFDARLQARTALLASSLAQANQELAQLALHDTLTRLPNRVLLEDRLEQAIS
KANRENTSFALLFMDLDGFKTVNDAYGHDIGDKLLVAVTHRLNQPLSGQFTLARIGGDEF
VLLAEVSAPDEAASLASALVHSIRCALYNRSVRTGRHP
>E0SCN2|diguanylate cyclase|EC 2.7.7.65|Dickeya dadantii (strain 3937)|TrEMBL
MHTEQSDNNELLLAEWQELVNLTSSDAHELLRDLCEEELRQLVSVFYDYMLQDKKASLYL
NTQQVANQLNESMYHWLRSVLGSATESLSALLERQQQVGVIHARIGIPTDLVARGARKLK
NELFRLLDRKRNLDAALINQAVCFSSLVIDTAIEAMTTAYSPGYKSAMRDQERYRILSIY
DDVNVERERQLGALMNWENQFIYNVATGLPSEEIVLLEKSEFGLWFFHKGRHLFNGPDLL
KKLEALIRQVDNRVRETFPHHVENTAIRTQLLRDVRQLVGQVNSILCSMFDELIKFENGK
DPLTNLLNRRFIPTIMRREIALAISSGKPFILAMIDIDHFKKINDNYGHETGNLTLKTIA
TKIYESVRSSDYVFRYGGEEFMVLLVETQTSQAAMIFDSIRQLIAGLYIPATAEKGISVT
ISVGIAEFDNHPDYQQLIKKADNALYQAKANGRNRIEIFG
>A0A752VQ81|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Carrau|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6N3LR02|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo SFn135|TrEMBL
MPLPSRLQTPVLLTVAILFTLCAVVSVTQIVKSLDLLAVNEHSTGRAIVQLMLLHQEYMN
DAENYFRGLIEVDELLTSYDLTWSAFEILLVGSESANLMERQGRLEIIVDTFESFKELDP
TLDSFNEIHFSQYLAHGQQTSETINALLNEEFQRVSEKNYSRDLELVRLNSIMGYSYAGL
AICGSLLLYITLKDRRKISHLAYHDSLTGLANRAALQNQLIDLKRQNSAGFTVLLLDLDG
FKLVNDTYGHDVGDRLLKRISARLLKTCGEGDFIARLGGDEFAIIQHSQEEPQVLPEKII
ESLSKPIKVGSVDCKVGVSIGICLASEYQDTWVDILKAADIAMYQAKSNGGNSYDFFDDA
G
>A0A653LK20|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. G8|TrEMBL
MQTESRLRSHPCAVTDVAEHNLTAEIERLRVELEAWKTRAAAAEAAADHDVLTPALNRRG
FVTALQRTMAYCQRHGVSAVLLYLDMDGFKSVNDRLGHAAGDAALVAVAELFLANLRESD
AVGRLGGDEFALLMLHAGYEEGRAKARQLSEALKTEGFIWDGQKTELGGSFGVRAWDGHT
DAEVWLTEADAAMWVRKKGR
>A0A6L3XU55|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
LFKPHCLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEA
FLIFLFTNMMVSLMMARNPLPMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERK
HITESEERFRNAMEYSAIGMALVGVEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPED
LNTDLEQLQQLIHGEINTYTLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDIN
DLKQTEWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLW
HAAMVPEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLG
INMDMTEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEA
LGQPILKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLE
GHTIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHA
LVFIDLDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVE
SARYIAGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNS
GRGVVTVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLR
LWTSQGEVLEAHAFRAGLAEPE
>A0A376TUS1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMCVPTAIFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLAYRAT
>A0A8H2BBJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEID
>A0A376P7E5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDMWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8G7XXX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLWVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H1S3E3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A786Y9C4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWMQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDGNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQRHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A368IUW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQATAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H0F3S8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRSALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A827UGE5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQSNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1C3RDW8|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MDAKKYKQLLEFQRSVSGKPEREIIQQGIELAVVLTDSEIGYIHFMNDDQETIELVTWSK
KTLEYCEMAFARHYPVSEAGIWADTFRNREAVIHNDYQNMPDRKGYPEGHAHLVRHVGVP
VIAGDMVCILMGVGNKVDEYGEEDVIAVQAVGDMIWQLVELRKKHVELENLQKKMHHAQK
IARIASWVWDRDDDVIECEDSLFNILGLPLESKKPKTMSELMRLVCPGKHWDQHMETVHK
TPFGKQFTCEVLHDDHNVKKRLLLMGDVQDRERGAGELVYGIVQDMSPADKMALDYWDAR
HDVLTKLGNRKYLHEIIGRTETRKRYQDRIAIHYIDLDYFKPVNDQLGHKVGDRVLQITA
ERMQAAVRYSDHVVRIGGDEFVVVQTNAQTKDHIESVAQKLIETISHPIAHEEEIIQIGA
SIGIEWSEGWHWNGDEILKRADKALYVSKEEGRGCYRFFDRSLLTEE
>A0A2X7F9B8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSLSLKQTQHLTVMLLDIDYLKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A826X003|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLISLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMAWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVLLLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHTLVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGRV
TVYEPQQTAKHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPDTRNLWLISLKLWSSE
GEIIDELAFRRSFSDPALNHALDRRILHEFFQQTAKAVASKGLSIALPLSVAGLSSAPLV
DKLLEQLESSPLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSSMGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8B4NF29|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDLHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A828GHX0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDIPLSLSIGA
AMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1U9T794|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQKLADHNMYQAKHQRAEKLVR
>A0A377DVK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLSQNDIAIYYLFRQMSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVA
HILSSHYESYNLHIAELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVT
VIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRD
PLTNIFNRNYFLMN
>A0A444R4N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
HIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNK
EGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEK
MSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHY
SITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQT
VNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFG
LLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQAD
IACYASKNGGRGRVTIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQA
RNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIA
LPLSVAGLSSATLVNELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRIVFS
QVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVV
LPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A797I143|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
RHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLV
VSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADI
AMYQEKKHKQKTPFVAHPALHS
>A0A377AIJ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPEKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMV
LYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHN
MYQAKHQRAKSW
>A0A377KD79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFRLAAFSLANSEQGRRSA
>A0A376ZYK9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELT
ETEPVIIFEGIEAPATLGLKASRSANYQRKKTRFLCALFSD
>A0A5C9AHX2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
SNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLIGDVVLRTL
ATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINIT
VTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A377D501|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQIND
TLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQ
HIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A2X7G4H4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFEGKTFVYYLYPVTHNRSLIFLIGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A377DH18|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVM
STRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIV
ALTDSYK
>A0A7A6QLU0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFYTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLKNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377CYM8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTISIGAVVTQKNELNPKEIYQLADNALYEAKETGRNKVVVKEAEILINRKDDE
>A0A379CSD2|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHTEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A5D8MPZ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSPRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A826X3Z0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTAQIDAILLDLNKSIDAHYQWLVKMFRCVVAKDISHPELSDAHSHFLCRFGQWLNA
HLVMTEEEIEYVRLISLAHEEMHLQGRELLTSIAEKRWQSTDFDRFQNTLLAFTSAVMDY
KIYLLNIRSNMDILTGLPGRRVLDESFDRQLLNAEPDKFYLLLLDIDRFKSVNDTLGHLI
GDVVLRTLAENLATWMRHNESVYRYGGEEFVIMIKASTDVDACMAGLRICELIAGNQIAY
PQGELHITATAGISRAKPGETLDVVMGRSDRAMYQGKLTGRNRCMFMDENEQIRHVAAAA
TELDNPCLTVI
>A0A6G4BIU6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRIPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>N9CQV9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter towneri DSM 14962 = CIP 107472|TrEMBL
MCQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSSSEQVQTITEF
IYQVDELIQKIGQCESQAQAIEMIQSIRAKNREILHLVDQIFQVSEYISSGNDALTQLLN
RRYLNTIVSREINFSRKNNSPLTLLAIDADHFKSINDRYGHAAGDDALQFLADVILQYAK
GSDYAFRIGGEEFLLLQIDTTIDRALVVAENIRKRVEKATLKTSTGEEFNFTISIGVHEY
DGHPDYQRFFEEVDKALYMAKNNGRNNVSVG
>A0A8B5N1M2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAITGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3L4X4G4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQCLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRVSAPF
NIH
>A0A376NIT9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRELTETEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDG
QIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLAD
GSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHIT
EPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRW
GGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKR
VDDALYRAKNDGRNRVLAA
>A0A485E130|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVSRAFPEEPLDVVI
GRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7I8ZCU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQYPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A484YW90|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMTYSLEAAVVFADGPAATETLAA
LGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFISHWLFPAPIIQPIRHNGETIGE
VRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTPPFAQWPGGSAEKYHRCRT
>A0A827B9U5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENRWQDAHFDEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQLVDNHAIAH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCVFIDEQNVITRV
>A0A827G9H3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVFLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A6L7CTB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
NMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDI
TEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIN
DLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSV
AKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A369FLB3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDSRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2X1KI11|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRF
KLVNDTYGHLIGDVVLRTLATYLASWTCDYETVYRYGGEEFIIIVKAANDEEACRAGVRI
CQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDE
QNVINRV
>A0A6L7CGN7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
SRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGD
EILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAAN
GEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5E4V1N0|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MVKSLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSSMQAQLDTQVQLVAEQLDDKMR
GKFLALHRMARHLGNPDAMTLAQFDAFANMSVSMPETFNTIFVAAPDGRMRYDSTFPATA
INIADRDYFRQVLAGAPQAASGLIAGRITRSPGIILAVPVVGAQGKTIAVIGGAINLLRQ
NFMVDLAINAVGASGRYCVTTNENPARYVIQADVTKILSPVGPAQTLCGVHDPGPNPLLR
MHPLVARATMATTGWSVVAVVPGAEAFDPLARVRRRVILLAIAAIGLAAFAMWWMARHML
RPLDTLRNLVRRSAGDMRAVQSLPVQRADEIGALANAFRDMMEQLRDRTEALEGSREAAR
ASVRRMQEIADRVPYLVAFLDSNERFAFVNRACELRLRRPRERILGATASELLGPSLYRE
FAPHLARAFAGEAATFIWDFGDDAAFRCFEVSYQPEWAAHDVLAGVHVFVRDITVERSNE
RRWRRESHTDHLTGLLNRKGFDQALAGALRVAREGGGAQALLFVDLDRFKLVNDTWGHAL
GDELLRRLAKRLVASVREGDVIARFGGDEFAVIMRDVQDILDVERTAMSILDAASRPMSL
SVGAVTVGACVGVAMVASGEVKTPDMMFDAADRALYDAKHGGRGRFVLGDGACVAD
>A0A1S7LF12|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MINFSQDNRWPNLLMLIMAIVAMIVGGISVFTLYHTAFKIQRERLVDTAKSRARLMESVG
RFNIAHPAKGYESGPFQATIKQIREAHKEFSGFGDTGEFTLAKREEDQIVFVLSHRHGDL
EKPRPVSFAAKLAEPMRRALSGHSGTVVGLDYRGEKVLAAYEPVAVLGLGVVAKIDLDEI
RAPFIRATLIVAGVAGMMIIIGVGLFSRITAPLLQRLKLTQKAVESVSEAIIITNTQGLT
IDINPAYEQLTGYSRADVLGRNPNISQSGRHDHTFYEKMWQSLAENGSWEGEIWDRRKNG
DIFPKWLTINVIKNAMGRVENYVGVFTDITEKKATEEKLRSLAFYDQLTLLANRSLFTEH
VEMAIAASKRSQHPFALMYLDLDRFKQVNDTLGHAAGDELLCEVAERMRRNVRSIDTVAR
LGGDEFGLILTEIHSSEEVAHLAQQLIDAISQPVALKEREVQVGASIGITLYPEDGDTPA
LLSKHADIAMYQAKEAGRNGYQLFSQKLQQQIETRVTLEENLRQATELNQLQLHYQPKVC
PETNQILGVESLVRWQPTTGPMVSPADFIPVAEETGLIVPMGEWILKTACLQTVQWSKSS
TCPVKMAVNLSARQFREPNLIQMVKQTVDETGIPPECLELELTESMVMGNVDEAVEIMHC
LRDLGLTLAMDDFGTGYSSLSYLKRFPINTLKIDQSFVRELQADGEDGAIVEAVISMAKS
LHLNVVAEGVETAEQLAFLKERGCGMVQGYFYSKPLPEDKIAPLIQHGFL
>A0A5E4WA94|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MKRTFLSTVSLTGRLRWLNLAVVCVVVVLCSSLLAWTWGTYQRASDASLALEALRATLLA
MEKASAERGPANAVLGADLPLPDASVIALRNAREATNARLQELLSALSADRCDACGGSLR
IVERARLDLAAASANVDLLVQRPRDMRGDAAVRDAVDRMIRVIPEFTSVASSRIDVISRG
APDALHYVVLARLAADLREFAGQLGSRFTAALTTGKPLAEVDQRAIERTLGRVEQLHDMI
AARMIDPPELSPETLDALNTQYFGAGLHYVATVRTLASQPQPVAPTTAEFARQYVPTMSA
ITDFRDNMLTLAQRKVDARAALALKWLMVTAIAAITLVLGMIVALRNFRRSVVQPFEAAT
RFVQALAQDNLDEAVPVDDMPTQRPQVRAVFDALRVLRLNTLELRQLRRDRTRLQSELEM
SGDTDPLTQLMNWRAFERQAQALCAMPSPGLVALIKLDIDNFTQINATWGHGVGDDVLRR
VGAVCLNTCQPGDVVARLGADAFAIVARVLAPSRAQQFAELMCGRIEATALTLPNGEVVP
LTASVGIAIGDPMTLGPTPVSSGGPANVSALLSQAERQLDAARRARRRTIE
>A0A379KPE1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MTELNPGDEIAHCVRTDRLRQLFVQSAPAVLGSFLAAAMLCWLGWERFDQQKVAAWMTVL
SLSTALRTAMFVAYLRAPANQRTAERWEWRYWATLALSAAVWGLGALAVMPADDLLGQAL
IMLFAVGMSVSAVSCYSSYRNMTLVSIALVLLPSTGWLLLQPSALQQGIALAVLVFASFV
VNATNSLSSALVTAWRLKHEMERAHRLAIVASCTDELTGLNNRRAFFDCALAQHTLCKEG
QTYVAVLMLDVDHFKQINDTAGHAAGDQVLQRIGAAISASLRDDDIAGRLGGEEFAILLP
DTPLVTASEIAERLRALISMLNVDTQFAVTASIGLAFAKAPASELDALLSSADKAMYRAK
ASGRNRVTIVDHVHAAA
>A0A5E4XSY7|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MPISAVFISIAVLSCVMSVAVLGSLFGTKVPGVRLWCLASALLAIVAALLLTGTSDIVVA
VSSSGLLIASLIGLRGFRQFLNARASYAWEYVALGVILVMLIYWTYISPHVDARSTMISG
CIAYVRFSIGGAVLKYRPRERPKYAYYFVAIAAILGAVVHAVRAIAYGLGLAHESTFLQP
TPLNVMFLGMATLTLPCLSVGMVLLAHDRLADRMERLATFDDLTGLLARRAFISRAEAIA
RECAHKQSTFSIAILDIDNFKSINDRYGHAAGDLALAHVASLIAGAVRATDIVGRIGGEE
FALLLPGETREHAGHLINRLRDIVASSGSCVPGREVMSTLSAGVDAFREGDTLASVMARA
DAALYAAKAKGRNCVVVAPAMEPLPIVVEHGNGAGFGGKTANG
>A0A109C8Z6|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MTRKVLIVGSNSDDMLQLTKLLEMVCGDFQVDTATCSTDAISYMESNKYEICLFEYRLSD
MNGIDLLRAVRKKGINYPVIFLTDASDHNVVVKAMKAGALDYLQKTDLSQETLCHTINAV
MELSRKNEEIRNMKDFYADVIDGVAEPIMVINLSYEVILLNRVVREKYPLPSETEEPRLC
YQVSHCCDKPCDGTNHVCPLTLVYESGHSIKVVHEHYQRDGEVRFIEILASPLRGSDGEI
YAIVESTRDITERRIAEITLEFKVNHDSLTGLPNRLLFNDRLCQAMAIAKRYKKIFALLF
LDLDNFKDVNDNLGHETGDLLLIEVGKRLRESVRESDTVARLGGDEFTVIIRNVEDINSV
ALVADKIKDNISRQYTLNSHTVSIGVSIGICLYSNDATNAEVLMKRADSAMYHAKKSGRN
CHQFYTGGSLIEPGI
>A0A518HYF5|diguanylate cyclase|EC 2.7.7.65|Stieleria neptunia|TrEMBL
MSLHSSEPSAKYSDTQTFEAGTLRVDEGVMPADRQAPRRAFLNVIRSRADFGVNAFLEGR
TVIGRSPTCTFPLHDLKVSGHHAAITPNGDGEFVLEDLNSTNGTRVNSTSVIGRRTLRDG
DRIFVGETVIRFSLADELDIDFHSEVATLIGSDPLTDLPSKRRFDEALEFSLQTSQRRAI
PLAVLMMDMDGVKQINDTYGHLYGAHVIGETGRLIAKVLGSRGQACRFGGDEFSAFLPGL
DLEAALGIGEQIRVAVESAGFEKNGVALRPTISIGVACFPKTAADTLSLVTDADAALYRA
KARGKNCVTS
>A0A2X3DVZ7|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MSDIILARVSQTLATEQSLESLVRQLLEMLELVTNMESTYLTKIDTQAQLQHIVYSRNSG
EMNIPENLSVPWGDTLCKRAMDDNCFYSDHVAEQWSDCDAAKALGITTFLSTPIHLTDGS
LYGTLCATSTAQKPLSFNSEHVLQLFASIIARYIEKESLVSQLQEANAALIYHSYTDALT
GLPNRRAIFDNLEMLFSLARHLNHAVLLAFIDLDNFKKINDLYGHQAGDAFLQQVGQRLK
LGISADDQLGRLGGDEFMVATLSRTAVQLEQFTETLRHLLIGDYLLGDTLIHYPGASIGT
VIIDPNKMNPDSALRAADSAMYQDKKFRHRTEISAQRLG
>A0A0T9UZ09|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MALHPTSFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYGAEEIIGQSFELF
YTPEDLAGQLPTKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDTDNNLQGFVHV
TRDLTDKWQRENALRKSEELFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKATAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRVSEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIAQHFGCFFLPEDIAAGLPEKLLKTAASAGRMEREGWLVRKDMTRFWAVTVI
TVVHDHSGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDG
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNHLLAFNQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIHDRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLTQAISQLGENEQHILCYVDLDYFKEVNDTAGHEAGDMVLRMVAQTMQQAV
RENDLVARLGGDEFAIVLFNCKNTPATDILEQVVADIAAIQFHWHGQSYAFTASLGAVSL
SRQIETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A433N4Z3|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MSASPPTFLTVDVRRSGLRFSQRVYIPRIVGTILCALFISSVLITRPIPTLLWVLLFLNT
FIWPHIAYMLSLRSRDPMRCEKHNLLLDVAFGGIWIGFMGVNILPSALIVAMVGMNCTAG
GGRTLFVQGIVLLCVTCALTLVLFAVPVSLDTTPIQIYACLPMLLIYPISLGYVTYATAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDICQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKSADMALYRAKNKGRRRTEVA
>A0A2T0AXY9|diguanylate cyclase|EC 2.7.7.65|Moorella humiferrea|TrEMBL
MIHEAFYDTYRNYLERYVCEGGTEVVLLEAYQDLTANLDDYYVQASNILDIHTRALREVM
GIRRDSDAVQWIYIDRATEFLAQILVVIDTFLLQLKDRIEHDPLTGLYNRIAMYPTLNNL
LKEAQEKGTPLVIAMLDLDDFKEVNDRFGHHAGDEVLRSTALIIKKALRAADKVIRYGGE
EFLVVLPGTSLEKAGIALERIRTQIAAQKMIPDHEEVTITVSIGAVEYPGSGPGDLNDLI
ARADRAMYLAKRQGKNRIVYFEPNKPN
>A0A378LV56|diguanylate cyclase|EC 2.7.7.65|Legionella wadsworthii|TrEMBL
MDFIKKQKQAALVAHSDSGFSKILLYSIFIPALLLVFIISIFSYFQVNKLVKTNYWVTHT
YQVIQNTDQILFSIVNINSYQRGYFISGDNQFLNKIDKAKLNFKERFDSLLKLTKDNLSQ
TERVNRFIDLINQRLNQITFNIPLRQNNKLQTPEGIDSFRQEVDLSNQIRDLGQEIKSVE
LALLQGRNDKALSDAKLANIIIILGSLISICGLFLTFILANKELSRSLQSEQQRKIIEIQ
LRSILESATDMIAAVDTNYRYIIFNEAYLEEFKRLFGISLMIGMSVDNIFSDQDSRNKLL
DIWKESLKGREFVKNIEIEVDEKQNVYEITSSLITNEINEIKGAVHIIRNITKQIEEQAE
LKESYNQLSLGMQALKDKNDQITLLVEMSDILLACGSLDELGNVMAKYCERMLHFARGYL
YVMHPSKNYLEIATSWGSPNEQKTTFSPHECWAIRLGRTHYVRPAHNQLICNHVIQEQID
NSTYICVPLMAQNDIYGLLYLELINEIPEGFSENQRLLITAFAELTALAFANVRLRENLR
HQSIRDPLTGLYNRRYLEDFLLKQIHQSERTNVPLAVVMMDLDHFKKINDTYGHDAGDAV
LKELGKILQEDIRVGDIAARYGGEEFIVVFYGVNDESIKSRAERIRHAVSRIQLKYGAQH
VGPITISMGISEFPTHGHTPMELIESADKALYYAKANGRNMVVLYAEIKNKRDYLKKVDN
P
>F5RRR1|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei ATCC 49162|TrEMBL
MEKRHNATPEPATWPTRKSMVVHGLAVNLPWLAFVNTSFAIMVLLRNSLFGQIDTLFHIT
PHLQLIVDATMLGVIILNGALVLMAWRHMRGVSAVLFLCGVLWSLCCYWFIYVIQLPHPW
PIFVTLLMAGMTALYFHPVALLCFTVPLWITMPVASMLLNQEINYRFVGTWVVFTFILVC
GRYILLSWFEEAWRRNQQNQRLISRLDALAHQDPLTKTANRRAMELVLENAVEQGKRFAV
LMLDVDYFKLYNDTYGHQAGDACLARVAEVLNTSVRTPEDVVSRYGGEEFVVILFDCEAS
VAEKVAARIQAGLRTAAIPHSASKVSECVTVSTGIAGYTAGLAGPEIIARADAALYRAKE
AGRDRWSL
>A0A8I2DSW3|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. RM72|TrEMBL
METDSEPYVRLASLRQLHQAMADMNKARSLADTLQAVADGVVQALGYELACVNLVGPDGD
LVVAAFAGNAAAEALITGRSGSRESWDRRLNMGEQWGDLIFIPHTEGWVLDDDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYAPGPQGGGTSGELIGVLSVDRPRNGRRPGAWGREALQM
YAFQAAIAISNARLRSNMQRALVRLERDQQALRASEESFRQAFEYAPSGMAIAEMGGDQH
GRILRTNDALCRLLGRRASSMRRYAFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYV
WVSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRSRLAA
RLCQRPQSAHAAVADAMDAAYGHSAVFDSGGHTFDFGAAAEPYGAFDHHVHAVAPEEGRD
DGTKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLSGGVRDGDTVARLGGDEFVIL
ANGLGRADAQDLAVRLRGEIIQPIRAEGRAVRVGASFGIGWAHCGMTADEVLKSADERMY
VEKRSRPKQHRRAG
>A0A8I2DZS0|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. RM72|TrEMBL
MGDDRRLAAVVALAQGMAAAHSAREAWRAAAVGGCLALGGSFAALSVWERELGRLRVLVN
VGRLAEGEEEFPEDESYPVHQFAEITEFLHERWAGGGEPDAWVETAAGPAAGRPGYVHQR
VAALRRRGRGCCVVAPIVLHGRAWGELYVARPVGERVFERADADFATVLASVVAAGIAQT
ERLEEARRLAYTDALTGLANRRAVDSALDEAVERHREEGVVVSLVVCDLNGLKRVNDTHG
HAVGDRLLERFGSVLSLCGAMLPGALAARLGGDEFCLLAVGPPADAVVKAAEELCRRAAE
LELGDGVACGVASTEDPVGPVRSARRLFRLADAAQYRAKAERAAGPVVAGREGPDDPVVR
LADQPSREEDGERRRFRGRHSP
>A0A241VUG9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5054|TrEMBL
MNQECITSLSQAWANICDQYTETEHLAALRFIQTHVEHLVTVFYEQMLLEPEAAHFFKDD
IIQKRLIDTLRKWLLETFEVAINFQFEPAVKRQQKVGMVHARIGIPSWFIMRGVREIERK
IFELLEQNNTHNVLHMCSYLVQIMGLSTEIMCRSYELNTEKSQEIKHNYRLFSAMQDVAV
HKDKQRGSLLDWENELMYKIFSGAVGFYHPLFSKSEFGLWFIHKAAYAFSGSDQVQLVID
RIYKVDALTEQTMKIEDRQQLQEFIQKIREINREIQHLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIVSREINFARQKQAPLSLLAFDADYFKNINDKFGHAAGDLALKFIGETLQRFS
QGSDYAFRIGGEEFLLLLVDTDLVRAMSIAESVRSYIEKGVIRTVQGQQFSFTISVGCVL
YDGHPDYQRFLDAADHALYAAKNNGRNCIQVTQHLSRV
>A0A377HKW5|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MSTQLEQIKKAAIQTRRVPLGADQRLMVMQKLQGQLDIAPLFDVFTQELEKQIDITRLIW
EHQEISHIVRRGGSSDYRQTFSLKFTNTPLGMLQYCTPYKLDDDEIALIHTYHRLLAGPL
SNAIEYNRVRNMALLDSLTGLNNRTSFEQDLRQSIAMTERNNHGLILMIFDMNNFKQVND
TYGHLDGDNVLRRFSLLLKEAIRASDRCYRIGGDEFAVILTPATKESAQLVNERLKSLVA
KDSLLSAHNISSSVGCTTYRQGDNHMSIFERADRSMYRNKSRHR
>A0A1R3U1X6|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MFQPLDLPTVLLLHKLSFFVAALCFLYVRSQSRESVGLGFLAVGFFLVATASTLVSIGKV
FTDYEHSLALAGTFAGLVGYSIFWIGMCRISTQTSRRREWLILCFPVIVCVILFVSGLYE
FTTARTTAMQSTAALLLLAAACTVFFDRVIEPLPVRRALAATIGFAALLSALVVLGVLFP
DVALVSSRNAFFVSIVCHFAIAVFVLALVKERAEEGLKRLADLDVLTGVLNRRSFSTRLP
QQMRQGDAIVMIDIDHFKRINDGFGHFAGDEVLARVAKELSARVRPNDSFARFGGEEFIL
FMPATGEGEASTLAESVRQLVSSIKHSIDDQKVAATLSMGLAVCTDKTCTPHALMKMADT
ALYASKATGRDRLTVYNAEDFERNPALSNPARHAG
>A0A1F2PJF2|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MDQNSNYFKKNLAILVSITVALFLLTVFLLIIGMFMHNLKQQEMLKTTDKFINFKSQLEH
LVFTNKTLVQGFEAYIQTNPGLDETAAYTYLDNLLSKNENQIRNIGVIQDTTIIWNYPKE
GNSAAIGVDLAKVESQKDLVLKVKNDQVPIFQGPVDLVQEGTGFIIRLPIVRQDSGYWGQ
ISIVLKGDQIIEEINSYADKAGLNVALFNNQNPEQPFYGDTSVVGESSLTFDIDPGFIDW
KVAVSPQGGWENNQLILGIAVMLAVLMAVGAGRLTFRALKINYQLRIMSSHDSLTGLFNR
HYLNEYQTMVLAAAQRNNRQVGLMSMDLNHFKKINDTYGHNTGDLVLIETARILQKNVRA
NEAAFRLGGDEFLMILPDIKDRQELRQAKERLAKSFASEFSLADLSEKLTLSIGTSLNPE
DGQDIDALLQIADEEMYADKKEQKSRLALS
>L4JB13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE146|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A564WSI6|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MERFRQRYGIALTKKKLQEIILMLMAWEAVFAFSYLGYIELPAISTTTLHILVIVAAMML
GAQGSVPVVCVFVVTSMWIGTYSLSQLDRVFSPFASGMPLGSIMLVFARVLFAAGAGWLF
DLYFRKPRRYVYLGIAGIAAASTLLHGLCVFAALYCSFPMLRQMILENLFSYPIFRDWLS
YVLAIIACCGIHWVLTRKSVKNRLSQLCDCPPAMQESGNRKQLIYSETVAVVVGILCILF
LRKAIFKELYLQGIDVSENLHQNITAFLLQTLVALLALFSVVSVLIQWIYEYYTAQRIRM
NKKLMEQRMKSSVDVLTGVFSRLAYHECLEQYADSVPTDLTVFLMDINGLKGVNDALGHE
AGDELICGAAQCITQAVGDRGKIFRIGGDEFVVLGQMTQTQAQEILAALQRIAAAWSGTN
VGTLSISSGCAFADDHPDFSVEQLTKAADLSMYAQKQEYYRAKKLSSGTPVSSGNGVRP
>A0A1F2PMM8|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNSEQESKAPIYLGEFRDERLEQEFYQAEIVAHFNWIRLGILAAALFFLVLLLPVYDRIV
DHHDFRIAASMIVVVTVALFFLFFKVSFATVGTLLSYWFTGYEIAVGLALLYLLTNLMPV
APLVQVLSLIVMILVVFLINSRWLLAVFTTLLLGVSYFVMVVVESGLSADARVAGLGVLL
IIVISSLASYRSNTYKRFHYLNLLELIRLAEFDALTGIYNKAKFNKDYDGLTERARRQQG
HLSVVMFDIDNFKEINTQHGHLVGDAILLELANFIQLHIRSSDIFVRWGGDKFILTFPDI
PLPLAAEIAEKLRVLIGDHDFAQVGHLSCSFGVAAFEEGDQLDSLVRRADQRLDTAKTQG
KNRVVQG
>A0A448CGD5|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MKDSNATVTQLALLQQKLHSAKLALDEVNEDRNAKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHNLNTFERVDEALPELVDVERLLKGQYHHVMVQLEESRAGLAQVVRQIQRVNSVP
EKLKKEINYFKQDLSKPFHTVWEYIPKVKQIIGFYDTILQQQFNETEKLDVLPKHRQLAH
ELAQMISEIEFRKDQRDQVLVIKEMLASDIEIDNLLEAYQTILSLLLDNIAREKSASQEF
LYALNDALAAVREVVSESYNHNQRSFQLKTQLNREINSRVDNVGEAIIDTDDIVDLKARL
TEQLNSIRSALARKEALEQREQALLRKSMETMRKELNELSNEANTYKERLFEQQKLNLLD
SLTQLPNRAALEERMELEYRNYQRHKSPLWIAIADIDHFKSINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLILPDIDGGDIAQLLNRVREKVKNIPFKFKNQRITVTVS
IGAAQVMGNELIHETFERADAALYKAKHESRDRVVIDV
>A0A1C6G129|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKKKLVFLAFATIAIALLLEAGILKYVNDSNTYRMSKVLLDRVITVLNKNDDSENGLIE
SLKDDYIVRAKAVSYIIDAKPQVEYDVEELQKIADLILVDEIHLFDKNGYIYSGTLPKYY
GFSFDSGEQMEYFKPMLKNKNLTMCQDVTPNTAEGKELMYAITWNEAGTRMIQIGIEPKR
LLKELKQNEISAVVSDMPVYKGIEIFVADSQTKIVKGATDSRQIGVKLEGLVVSSDKKSG
ETDVRFIRIGGKRCKCLLSQYGSYIVAVTIDSSFYRQGNIFAVLIVGVYLVLASCCMFYM
LSRVMKEKYEKEKLLYISNTDELTRCFNRHAYEERINNLDLREEWIYISMDLNNLKHTND
SLGHAAGDELICAAANCMRESFGKYGNVYRIGGDEFVVIITGNTKEFQSIIESFDRCVAQ
WHGKLVDSMTISWGYVFSSEKEWDNIYDIAKEADERMYKNKERYYQESKIVRRR
>A0A1V5BVA7|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin065|TrEMBL
MVSRLTTRQLLIKKVEEMIYNREGPFSIVVADIDNLENINNTYSPKIGDEIIDKLVSIFM
NNLSENDLSTRQGDEFMILLVGKGAERSLMEMEEIRRYLSDNTFGFSDGEIQDDIYVTIS
CGIASWPRDAKNAIELLRVADSALFRAKKLGKNKVCLSEVESMVLKSSYFTKTQIDRLSE
LAKEMEKTEAFLLREALDDLFKKYSK
>A0A853W1J0|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MSVERVYLIDWLRVACKGSKFFIYLLVLTWLVYFILTSQLRARTRTAAILLFIGLPLVLA
GISLDLLGEFFHLSTLLKRIVGELILSNTGTFLVLYSMMLMIMELVQASCRYQREAESDP
LTGLYNRRTFFASAESVLKEAREGKRSPMLAILDLDNMKKINDTWGHQYGDEALKRVAQA
IQKSVQEGDVTARYGGDEFVILFPGKGPRLETLRARLKKHLQALRLSGAEIPLSLSVGLA
RFPADGKDVDTLLAVADARMYADKEGKKGRRRAGI
>A0A1V5BUX4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin065|TrEMBL
MLQSEAVQARRKSKRFSLVLIDPELLQPFHNPWGRQAREHVQGIVAKVIKRVLLEGDNVV
RYRGEGFLIFLPNAGSLTALLVADMIRRAVERTKWPGGMTVTVSAGVASYPDDGERLTEL
LKNLESALSRAKSEGRNQVHCVSVRL
>A0A174C923|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MLVEQIRQIILNKPIKEELKSESEELAELQEAVLYLSGLLSESNEFLKHLQAGELDVKPP
GRHNFLAGNLKELHSALKHLTWQANQIANGDYSQKVDFLGDFSASFNSMIHQLAEREAKL
KHQSVELSDMVELIKSIVDGLKDWIVVIDSESDEIIYTNQSANQLFYDMEIEKNTCGKKC
ELIEQLRKQSQDCKNSIFEYTCPKSMKILRVKSFGIKWNNKAACVHCIQDVTDECEYHEQ
VEEMAYTDELTGLYNRRYCMKQLERQLSQKNEFSFCMIDLDGLKYANDNYGHASGDRYLK
TVADEMLKISRTTDIVCRIGGDEFAILFLNCASDIALKKMKQANLSIESLSEGFLMSISY
GVIHIEAGMNISPETILKWADKKMYALKNTKKHSRSHGR
>A7ZLT8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H28 (strain E24377A / ETEC)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7W6A4F7|diguanylate cyclase|EC 2.7.7.65|Brevundimonas mediterranea|TrEMBL
MSARILVVDDVDVNVRLLEAKLTIEYYDVLTCNDGATALDLATEHQPDMILLDVMMPGMD
GFETCRRLKARAETRHIPVVLVTALDGREDRIRGLEAGADDFLTKPIDDVVLFARVKSLT
RLKQVMDELREREESSRRMGVDGEGAARLRSEGGRVLIIDDDASQAETIAAELGREHRVS
IESDPEAALATAKGPLDLIIVNVAAESFDGLRVVALAKSGDARRAPILAIVEPKERPRMV
KALELGATDILPRPIDPEELSARARTQIRRKRYTDFLRQKLDSSLEMAVTDALTGLHNRR
YMTGQLQALVGRAAHGGATVAVLVLDIDHFKSVNDGFGHDAGDEVLAEFAVRLATNVRAV
DVPCRMGGEEFVVVMPGASLEDARMVAERIRRDIASAPFRVMGGKELLTITISIGVAATT
GAGDTPEALLKRADEGVYEAKASGRNKVIAKAA
>A0A173ZRA0|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MKNNRLFKTNAVISLILLIGFVLTAALSYHANYRTSLDSMEQISTLTADGICYQLTAMFT
KPVNVSLTMSHDSLLREHLSKETEYLEDEKYVDTTRNYLDTYREKYGFDSAFLVSAATSR
YYNFNGIDRVLTEDSPENAWYYDLLKSDAEYSMNVDNDEVEGADNVLTVFVNCKVKAGDG
SILGIVGVGIRIDYLEELLRTYEDKFNVTAGLLGEDGTIEISTAHNGHVKTDWFELNGRH
NIRGQILDWREKNTNLEIWADKEESGKERSYIVARYIPELNWHLVVEQNTGQLLHGIRIQ
IILTGILLIIIVVSVLLIITAVIRNFNKQITELMEERQESFVRATEQLYDNIYELNITKN
CSVGKRTREYFKSLGANDLPYSEGLRVIADKQIKEEFREGYVSTFDPPNVIREYERGNHH
LRYDFQMSEDADKYFWMRIDAYVFYSAEDDSIHMFTYRKNIEEEKKIQIQAVLDEMTRFY
SKRETERLIETVLSGTPGGRYAFFIFDIDNFKQANDCYGHRFGDFCIKEFSSIIRKHFRE
KDILGRIGGDEFAAFIPVPDIGWARKKAGELAEALNTVIENQDRSWQMSVSIGVAVYPEA
GTLFEELYGNADKALYETKIRGRNGFTIFQPYDEKGQETELENE
>A0A1V4WKI7|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin006|TrEMBL
MKDSGLFALDILDVAAAWINREYIHKNANNRYCSAVNRLLDEVVNRSLADIWGSETFDTY
LKTDVDRCLSGHQVHRETSLDFPAPGLRLCKILYHPYPDTGGVPTGAIVMIHDLVEPEAE
KVNLQTSFEYLTEASREAIILVRDGVIEETGETFGRLFGYAGKDARGKPISDLIAPDQRT
QSMEQIQGQAGGIFKTVGLRHENLRFPMEVNFRRVHLEGRELTVWAVRDLTKFEEIKHQV
EAYQKHLEQMVRAQTQRIEKRESKYRSFYENAIEGMFRVDANGRLVSANTALAKMYGYDR
PEDLIRTASDLGDVYTKPKDGGKVTKLLQNQGVARDLETELYTKDGGRRWARMNVRAEKD
KDGRILYYEGTLEDITEKKWAEDKYRNIFLNATEGIFQITPEGRCFNANPALARIHGFNS
PEELMQNATDISTQLHVDVETWYNYLALMEENGYVRNHLWKMYRKDGSIAWLSCNARVVR
DETGQVLYHEGTIQDITDKQLMVDQILMQRDLALRLAQTGAVDAGLALVLETAVKASGME
SGGVWLKGPGEDMKLISSINFSPAFEKKCSFMAVGSRHWKRMMNKIRMVMAPTRESMPNI
HEEGYKCAAVIPILHDGRVIASFNLFSRTKDTISEQVLINLDFLAGQLGSIIVRMGIQQQ
VEQEIKTRREAEKALQAEQQGLEEANIALKVLLGQREKDKEDLEQRFVSNVNELVLPYLE
KLKKGRLEVLQRSTLNLIETNLKEILSPFRVNIRNFNLTPRQMDIVTLIKQGRTTKEIAG
LLNTTKDAIDKQRFIIRKKLGVNKDKTNLRSLLLSLQ
>A0A7L6PNX8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00127|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A643FQ63|diguanylate cyclase|EC 2.7.7.65|Cupriavidus basilensis|TrEMBL
MTPDLDVRPLPTIYPRWQRVSLAAIAFFLLALAGLAVSRYPGNVAMLWLANAFGLGILLH
QRSGDALWQLAGMLVAGLAANAAMGDSPVIALALALGNVAEIAFSAWLVRAMTGGATLSR
PGPLARFALTLGAASTLGPAVGATIGAATISTAYHSGFGAVWWTWWTADSMGIVMLLPLM
VSITRERFADTFRRAQLPRFAGLLLLSLAVGGVALYKSNEPFVVMALPLVLAALLTNPFA
TALLTLLAICGAVALGLVTASLGVGANEPFLLQSVQLSTALIMVFPICIAFLLEQNRRDR
SELRGSERRFRQAMEHSAIGMALVGLDGRWLQVNRAICDLFGYDAAELAELPFPTITHPD
DLAPDLHQVERLLAGEIESYRIEKRFRHKDGHYRWTLLAVSLVHDEKTGKPLHFISQVED
IDERKAALEKLEALSRRTQLAVEAGGVGIWEWDIASGAIEWDARMHALHGVDPALGAPDI
KRWTAMVHPEDVEQASTEMREAVRGTRTFDTEYRIQRPDGAVRHIRAMAMVLRQDDGTAV
SMIGTNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDATMGVTFMNPIAEQLTGWT
MQAAAGQPLESIFRIVDEHTNAPIPSPVEQCLLSLRPVYLQDGAVLQSLTGDRHDVQDSA
APVRTATGEVIGAVLVFQDITGARALQRELAHSASHDALTGLPNRIWFEKRLREACEAAR
MQQQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRYHVRPDDLLARLGGDEFALL
LMDCTVDHAERVCQKIIDAIRGQRFPWEGRVYDVGASIGITAIDHETPPMGELMSRADVA
CYAAKAAGRSRVSVYRRDESDAQRHHQELQVAAGIHSALDANRFRLFAQEIRALQKHNQA
ERHIEILVRMVDEQGKLVMPGAFIPAAERYDLMGHVDRWVIHHVLHEFGERLTAVPRLTV
AINLSANSLGEPFLLPFLHAELHESVLPASRIQLEITETALINNMAAANRLVTEMRSAGC
TVALDDFGAGLSSFSYLKQFPVDYLKIDGSFIRHLAGNAVDREIVSSINDIGHRLGMLTV
AESVEDEETLQALRSLGVDYAQGYVIGRPMPLELFLESCPTQPVDNA
>A0A087CR61|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium reuteri DSM 23975|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKVQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVADLEINEDSHDVTRAGQPIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVTDDNGEKHKVTPLIETKRGIGYMIRE
PKH
>Q8EHL2|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MTGRFKSLTWKQTNLVVFTALFFAIAIFIVEIALVVVSTKQQLTTTQQELLDSVEQPAAN
AVWALDDNLARQTLEGAIKVEHVGSAVIELDDGSMFVSVSNNRANNSQTFISLSNQLFDD
LKEISRPLYRPFYFEGTQKQQLIGTLTIFYDTQELTNTLFSQLRFSFFATLARALLLTLV
LTVVFHRFLTQPIARISEAIDKIEPDSPDENLLPMSNAHKDDELGLVTSKFNQILIQFSQ
TQSKLRKMATRDPLTGLPNRTLLLETIAVTIQRSRVHKRSFALMFIDLDRFKNINDSLGH
ALGDQFLARIARILERVVGDKGSVSRLGGDEFVILADSVHSPDQAADFVDKLLVQLNVPI
QLNEHAIHPAASIGISIYPEDGSSAEDLIRHADIAMYSAKAAGSNQWAFFKQQMTERAAV
RLRTEASLHDALKNNEFLLYFQPKLDLQTGKITGCEALIRWQKDGRLISPMSFIPVAEET
GIIIPIGRWVIEQSCRVLREWQKKYNYAIPIAINVASQQFADASLVSDIKQMALRYQIQP
ELLEIEITETSLMNDIELAINKLEQLKSAGFGIAVDDFGTGYSSLSYLRHLPITTMKIDR
CFVSDLPGDSAIASTILMLGKQLNLTIVAEGIENELQLDWLKSNECQIGQGFYFSQPLPQ
ADFEALYMASQTATISNLDGLRGT
>A0A1S8T825|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MSNFFINILLLISGIFLGGHLSKNTPLEYSSKVFTKVLLGLGGGILAIGMMIYAINIEST
KTLVDLRVIALMLIYNISGLLSSLVTGIIIVLFRFLYFGINQSSIVAVFQILILLLLFSI
VGKLKLNMIKKWITIYLINMLSMISTYYYLLSNVNNVFNILLEYFIISAVATILAYYLLK
YVRSSNELYRRYKNEATKDFLTGLNNTRQFDLIFNKSAINAKEKDEQLSCLMVDIDHFKH
VNDTYGHAVGDIVLRELAVILKNSCRVFDAVSRVGGEEFCILLLDCSKERTMDIGKRICD
EVKKHEFEIGDGRKIRITVSVGISAYPESTDNIEMLIKQADDSLYKAKQTGRDRVCSIDT
CDTN
>Q8EJW5|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MLGFIGVALSQPILRLIFSVLCIISFFTVPSTGLALPLNAANTQLKFEHIRSEDGLNQNT
ITSLFMDSAGMLWIGTQDGLHSYNGYNFNLFIHSPNDPKSISESYVSDIIQDAEGYLWVG
SFSQGINRLDLKTGTFKRFGVEQGLTDPRVTKLNIVGNTLWIGTQSGLFSFSTRTNRLTK
VSLGTSIEPYITSLANVDNTYLLAGTKGSGTFAVSANTITRLNIPQDAIAYQVKANSSRA
ITLALGNQLWHYDLATQQGKALWQADKNIPYIKDFIQTPEGQFWVVGPEAGLIQLEREAD
KFVATYHQYDMKRTNSISENNILSLLEDPFGNLWLGASYSGLNKINTRRQYFQHLFEYTN
ELPLQSNNVRTIYRSQDQALWIGTEGAGLKRLAVNSTTFEHYTSFFAKALGQQTQHLNLI
LRSIVQDKQGILWFASNYGLGRLTPNGEFNLLNVADSRDTSAEANYIRSLELDNQNRLWV
ATSHALYRKSSVNDEFTPVPLTGIENFHPIQNLLLTLKSDKNILWIGSLNGLVKLDMQTG
HGEVFYHDPHDKNSIINNRIRDIFVASNGDTWFATHGGISRLPAQALSPIFSDYTREQGL
PSDTIYALLEDDDNHIWFSSNAGIGKLNPHNGKIINFNEQEGLQALEFNGGVKLKDSDGD
LWFGGINGINRFNPKTLPNQRSEARVALTAYKIAGQKQTILDLSHPPQIVMNYADQLISF
EVTSLDFSYPGKNRFSYFLEGFDNQWHDLPTGNEITFTNIDPGNYLLHVRHSLEYNSKGN
YALLVNLTVKAPFYRTPFAYAFYVLFTLVSMGWALRWRKQKRSQQQEFETSIRASEERLK
LALWASGDGMWDWNIQEQQVYRTNTDIAVPQWNGHQLLHDNAHPEDRERFKYELTEHLQG
RSPFFEVEYRIEHSPGKWVWILERGKVVETNAQERPIRMTGTTRNITSRKLIENELVLSS
QVLNSMNEAVVVAGLDYRIRSVNPAFSAITGYSEGQISDKFLIHLAYSRQQRDLFNSIEQ
QLLRHKHWAGEIWIRNKARRAILVWLEINQVIDVKGETSHFVAVFTDITERKKAEEDLRF
LASFDTLTGLPNRTLFQDRLNHAISQAHRSNNIVALLFLDLDRFKHINDSMGHHIGDLLL
KAVAHRLQSAVREGDTVARLGGDEFTIILEGVAKTKAATLISEKVLKAFQAPFLLDDKSL
NISTSIGISLYPNDAKDVDSLIKFADTAMYHAKALGRNNFQFYTNKLNEMATRHMQLETG
LKQAISHNELSLVYQPKFCLRNGSLTGLEALLRWQHSELGPISPAEFIPLAEETGMINQI
GHWVINQSCQQLAEWNELGFSDISMAVNLSARQLKADIISTIEVALAVSGLPAKALELEL
TESMIMGNPQESVNILSKLKALGLTIAVDDFGTGYSSLSYLKRFPIDTLKIDREFVRDIT
NDPDDAAITSAIIALAHSLELNVVAEGVETQEQLNFLALQGCDQVQGFLLSKPLSAQDCQ
TLLQQRTKDRQDVKK
>Q31WC0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKYPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>Q8ECQ1|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MPKVLLKIFIYSCLCLSTLYPSDSIAIYSKELDSSIVLNSNLFGVPQGLSQGTVTSIVQD
NDGYLWIGTFNGLNRFDGSNFKYFFADGTNSGLPSSFIRSLQIDKNGILYVGTDNGLAVY
DKNNDSFIKYGAPLDNTPIWSINTTIETLIVGTNNAIIDIHGKENHLDLSSKGIGEIKKS
IKIGDDYFLKDYSGKLFKINQESSILIKENIIDIEQKNNKSLIISTKDGLFEYDGVLINR
IDNRSFSQLAKNNNTIYGISENYIIDINNKKTIGLISAFNPDKTTVFYANNNFFTLGSVD
QGFFIIKKQNNLVKKTSLTTNSTWHLSKNSQGFLVSSEAEKITLFNNEFKKIRDYNTYTT
GYKYALLHKNQLLYGTSNGLFLDNSNSVKKLSNETISALSSNEDDSILSAGTPDGKILII
KNSEIIKTFNTERKEPIFDIETISENLFYIASQGGLRKYDNGQETLISEQLTYSIQKDRN
YLLFGTSKALMRYDITNEKIDTLFSKNKEIYSIASDTNFITVSSLGEVIIFDKNSKTSYA
LGTSNGSQYEYNSPSAIKINDFILLAGINGVSLVSPQEISDYIKSQKANKTEISKFSVFN
MSQEKNGKYLKKPIDVTKEITLKYSDYPFSFDFISPMSDESSTNYYYRMLGLSDTWIYSN
GTNSATYTNLSPGEYVFQVYTINNLSGEKSSEREVNVIITPPWWSSTQAKIFYFLITMFL
SLFIFKAILRKREIQRQIALSEERLKLSLWGSGDEMWDWDIETGNIFRSNIWGALEFPRD
GHRSGNRDEESNIHPMDQERVREALNKHFYGETDHFEAAYRVKGKDDSWIWILDRAKIVE
RDDKDNALRMTGTIKNISQFKQKEEQLRLFEKAIENISEGMFILDSEYRFVEVNEACCRI
SQRNRSDFIGNLLTFELYPESFSNQIRTMLKQQGRWASEVEANRGDNSHFHMELTIDAIY
DELGELSHYVGVFSDISRRKQQEEELRKLTNNDLLTGLPNRSNLQVTLGNLVNKEINHAL
MVLDLDNFKRINDSLGHQVGDKLLKLVSVRIKSSVPKNTNIYRLGGDEFAIVLDKTSDIL
ASAAIAGRIVDAFNTVYEIDNEQLVLGVSVGIVLYPDDEQNEQALLRKADIAMYHAKSAG
GNCYQFYSESLNEHAIKQLETENLIREGLKEDLFEVYYQPKVDLKHGHVAGMEALVRLNH
PTLGLIPPNDFIPLAEENGLIVEIGEIVLRKACFAAQKWREQGLFKGRVAVNLSSRQFAL
PDLQQRIESILRLTQLPASHLELEITEGTVIKQPEMAITVMQQLAKMGVSLALDDFGTGY
SSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDSIITIAHNMGLSVVGEGVEQAAQLN
ILRALNCEEIQGYIFSKAINEAEFTLLLQEDQAKSIAINNTL
>A0A1U1CC38|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MTALVKVTSMLLVVVLIPAVIQFGIAVVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGEL
RREQPLDGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLIDVAHALTSGTTGTSVVGRSGG
EEFLVVTVCPASAVAEFAARLRQAVTASMPAGIAVTASVGVAAQAVSRVVSATPQEAIEV
LTACADRAMYEAKHDGGDQSRILHADHDSEGRYLWRSGA
>A0A6L6GJ23|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J316|TrEMBL
MIADKSSRAFRPEHIVHICFAIVFVFSTLLTWREAQVLKSSYETDQRAWLAQLASGLEHQ
LQQSIDEMYFFRNMLHHALDEPLVTDKSREALAAFAVKRHHPLWKININSERSMPLNGIS
DEALQSFPLLSRADPKRLDDELTAVLEMSYILQFNNPVSDLHYRLWYISRAGFYLSSVQD
DKQETVKSYSTAIDRPYFLNAHPQSNPDRGMRWSESYHSLYNEGEVVTVTLPVDHDNYWY
GELAMDFSTEAIQRYLRQTLPTWQAGHVMLFDRKHKPLAISDGKKMSEQGINSAELAEIF
NKRPDEKSGQIRSGTRFITWVRLQHFDGMMINVQTLDEGMRGETGRVTLVLVLMWGLFTL
VLLACHQAIFRMIRRMLSLQEALKRRANYDGLTRQLNRSAFFEQARKQSAFCERHQLPLS
LIQLDLDHFKSVNDTWGHHAGDVVLTHAASVIARTLRKEDVLGRVGGEEFCVVLPDTSLA
EAVEIAERIRCKLASKEVLINAMKTLKVTASLGVSSSDEQQDYKIENLQSIADERLYRAK
QAGRNCVSSGG
>A0A259V058|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MERANMIGGKYSKYLVLAAIVLPLIFIAEVAYVERQPVKIINQEQTKEVAKLRAEAKTAW
LSSQAAYVRGLANSSIVTADLETAQADFQSFLAAKTGFMALGYAGTDGKVVLDTSGARGN
DISGHNYFTEAVAGREFTGQVSGTDWLLSEDVTIIALPVSQHGAVTGVVYGVIRQEPMDT
MLAKLVPGTIIEPRPVDRWLMWLGVVYLLGIIPLLLLVYLLCRQQPPVMPKRAHKHTPAA
GKYITRTPDAAISVFHRERPVLSREKERVTAEKGFADDAVATTPEAAIAIRKIAEIVAAD
QMHEQPDTPDMYAKPAVKPAATTPAAVIDRVLAVAAYNKGRAASMSQPNAPAKRVAAAPV
EPVPMPELKQQSVIIAPVVSLPTSLPTEKALPGQSSAPDLPVYDTLTNTLTRSAFEKKIT
AQYGQSEQGIVVLSIDGMKVINDFLNTSAGDRLIKAAADILIAVSGSEYTVARVDGDQFA
ALLTAVSTDRLEEIKKDIKYFIDLHNLREPELPLSITVGTAMAKHGENWTAVWQRAARDM
ESHKAVNRVEARRFIMWSMKRYRRKS
>A0A0P1ES42|diguanylate cyclase|EC 2.7.7.65|Shimia marina|TrEMBL
MHLWGPKMREQRQPFIADPVGACDTFRQEQMLEVLNQMEQGIVVWDSDQNCLMFNERIFV
VLEISPTDLFVGMKREMFLDKAVQWGVITAGSKEEAQARFQTGQPFSFDRSLPSGKVISS
FARPLGQGGYVVTFTDVTQFRKDAADLAVAKKAAEKAETKALKMLAKEQAWREEAKLLGD
LDEWLQSCKSLAELFEVVTQFMTKLLPDTAGELYLYSNSRDVLDGACVWGGGEVQEHIAP
DSCWALRRGRGYRYEAGGIGLQCSHVKDHPRQREVEHTLCVPIVAHGDTVGLMHVVYPEN
ASDAEVRQGYEFALQCGEHISLAIANVKLRDELHDQSTRDALTRLYNRRYFLEAMRTEAS
MAARKRSDFSLLSFDADKFKSFNDNHGHDAGDMVLRAIADKMHEMFSDGATPCRFGGEEF
SVLLPNVTGAEAYDVAEELRRAVEEIKIRYGSGELPPVTISIGVASFSDHGPLLQDIINA
ADRALYQAKKDGRNCVRAADAEAQ
>A0A6L6GLL1|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J316|TrEMBL
MTIKTLTRVAPLNPTWVDGLLLGLLSFVVTVYCLELIKTTGQISPLWCSTALMTIVIFRN
PRHQLPLLLLGTLLGIICANTLVLGTSPYNLKFPLVNLVQAMAGGMLLRRLLDRDAPLNS
LFSWCKMMLTVGLFTPLLGGLLASWLSNVEGNFSLHFFTTWTLSEAIGMLAFGPVCMLWQ
RDYVRRHLRQNVLFETLLTLMVTLILCWFSLRYIPWPFTAVVLILFYSAVRLPRFEAFVI
YMATISMMSLMLALKLIPGDTSHFQALESMPWIPFLLALIPSHMMTLVMHSFREERKHIS
ESETRFRHAMEYSAIGMALVSVKGQWLQANKSLCRLLGYTPAELYALTFQDITPPEDLPA
DLANVNTLLAGEVESYSMQKRYFRKDGQILWTLLTVSLVRDSEQVPLYFISQIEDISDLI
KTEKVNQRLMERITLANEAGGIGVWEWDLQNGVMSWDKRMFQIYRLPTNSHASYQNWVDS
LHSADRSAAVRAFEDAIKTTLPVDIEFRIETDIGIRHIRAQCSVVLDEKGEVERMLGINQ
DITPLRQLTDALHEEKERMHITLDAIGEAVISTDEEMRVIFMNPVAEKMSGWLQHQASGR
PISEILRITQGSNGPARENLMLCDLPLQKNPGEMDAELVLHSRAGEQFAIHYSLSPLKKL
TGENIGSVMVIQDVSESREMLKRLSYSASHDMLTRLPNRVSFEHQLKRLILSCTAQKQHV
LVFIDLDRFKAVNDTAGHAAGDSLLREISGVMQRHLRAGDFLARLGGDEFGVLLAECSLS
QASEAIRRIVQAVNEYDFLWENRTHHVGASAGLTQISPENSSVSELMAQADLACYNAKHN
GRGQLSTYESHLLKRLKPVMNRIENEQIIAQQPMLLQVWAAAPPGRTLASSFYLAEMQLF
TPEGHEIDEVSFRTGLHDSDLFVALDRKLIREFFQNYAQGTISRGLTLALPLSGFGLRDS
TFINDTLAEFTRYNVPPDAIWFAINADVLSQCDEILHQNISRLRAAGSRIVLRDFGLNLD
AFNQLPADEIDYLILASELVANVHCNLMDEMMVSIIHGHAQRLGINTLAGPVKLPVALDT
LSTIGINTVWGDVIAPRQPLSALLTDSHFAIK
>A0A564W6P1|diguanylate cyclase|EC 2.7.7.65|Blautia luti|TrEMBL
MDYRKKKNLIWKGESFLFVVVLLVFGVIFAAIHTGGLIQNQDSVQLLNKGWYYIKDGKKQ
EITLPAEIPAKTGEKLILYNESLGAESRGMTVASTGAQYDLVIRLNGKILYEYKEAMFSK
NVQMRSKVQCIAALGNNTEGKVLTFSYSAPQRGKYVIEPVCIGTGSAIAWYQIRKAAIPL
GAATIMIVLSMIALCICIYMRIRQMPDRRFRDVALFLMMCSIWLVTDSSLAQSYSRCPEV
LCLISFYMFMLLAVPMLRFLQNIGNMKKYRLLDLGIFTFYLNAVLQGVLVILGAFEFKDM
LFVTHILLFVWVLISAVLLIQEYRKHKQREIHLLLIAYIIVGASGIIALILYWLFEISYY
GSIFELGNLVFLVLVIADAVMMMADNVRYRLESQAYERLSREDGMTGLETRANFEKKLES
ISADTGRYRDILLMYIDIDQLRVINEEYGRAAGDEMVVISARCVENVFREKGTCYRIGGD
EFAVLVYDPEVPDEFWPERLKEELRNIGRGCRHCCSLSLGCSHLRNKEGSLKSIGEWKYE
ADRKLYENKKKGDLKNGVY
>A0A380W745|diguanylate cyclase|EC 2.7.7.65|Afipia felis|TrEMBL
MPGTSLSLDISTLYLVATFVAAMLGALLMFFWRQEKIEALGWWGAAYLLGAASIALWIAG
GENLGFGLLLAVNAVGFIACGLVWDAARVFHGRAPSIIGVVAGAIVWIAAVVLADPLSAH
TRLLLGAGIVAVYAALTAAELWRERRKSMRSRWPAIFVPVLHGAVLVLPVIIGDVMDGPG
TDPHAAIWVAIFAAELVFYAIGTVFIIFMLVSERTLAVHKTAASVDPLTGLLNRRGFSEA
TARMIEREAKAGRSITVMIFDLDHFKSVNDTFGHAAGDDVLKVFANAAVGALRITDLLGR
VGGEEFAALLPCSMDEALVAAERVREAFEQSGVTIDDVPLATTVSIGVAGGPANTELDVL
MASADTALYRAKRGGRNRVEAVLEEPLVLDHARRGGMSQTARPEKEAVHAFVSEAHA
>A0A0T9LZZ9|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MSELDSLLMLYQDACVTYATLSICYFSLSKNSAFSYNGEVWKRILFGLVSGLVSLYLNQD
KWIISGSFFYSFELIPIILVTFYGGWLSGLTALVINFTFTGWVTLDNLLIAIVFIPLLFS
KVWENKSNRIFYITIILIAVYRIFTATLLVPNTHTLTQVVVYQLCSALCLAICYHALNFK
ERHIYAYFAMKSRANIDKLTQLNNRASVEYRLATIHSTRQACGLLILDLDHFKLVNDTYG
HDGGDILLTEVGRLLMSVTRDEDFVGRYGGEEFIIITHSHDPQTIKAVAERIRQCVENLA
VQLADGRKIKATTSIGASLYLPGMSMLKALKMTDEALYQAKGQGRNRVVYSRLMPFSPLG
DRIVKDRRRRSF
>A0A0C3IQX8|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. KHS3|TrEMBL
MRYKDKHQLAAEWQALLERTPKPLRQAVETLVEHHGQSFADHFYRVMLEDPHASLFLSND
QVEQRLHPSMQRWLKAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLSGARQLKQVF
YQQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIAAQQDIATLPRLSNSDFGLWYFHKACHAFEGVPEIATIS
RHIQQVDREWLEVLMHEDASQRLKALGEIRDAARTVLMLLDNVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A0T9NJ11|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MFCVGSVLYTQNAPLWLWFMLVLNGLVWPHISYLLATRSEQPFEQEIINMKIDSALGGVW
VAIMSFNALPSVVILSMMSMNNIASGGKNVFCKGLALQIACSLLTAWIFNLPFKPETSPL
QVYACLPMIIIYPSLLGLVTYRTAKRLAENKEELLRISVRDGLTGLYNRRHWEHQLHNQF
DSCRRYQHGATLILLDIDNFKSINDTFGHAVGDEAITVLAEELLLGLRAIDIVGRYGGDE
FGAILPNTTAEQTREVLMRIQEKLADLVFTQAPSLQLRVSAGIADYRHDMINYQQWLKAA
DSALYLAKDNGRNRIELAS
>A0A155ZBG9|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASSADTLERQAVEQRQKFDQLTEDIETDIWAQS
DLARLYAIKKDPQVLKEYNQAENSLKRIELRLEKLQDNGASDEELALLHEGIKIVDELQD
EQQTALESLERGEDAQAVALLYGQPYEQELERAQNQLDHFRQILDKRVIAAVQEATKKSK
ALRTASELTVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAISIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYVLDREPWQMRCVAQWLSPVGEETTFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPASQAESALCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQKAQAIRTGVPLSCMMIDIDHFKSINDRFGHEA
GDLVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLSGADEAEAYACAQKIYTGVHELSLRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A433BFS3|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp|TrEMBL
MNELPEQEWARTVQAAPQACRDLVAGVAQAHCAQLAKLFYDSMLAHPHAARFLNHDLVHQ
RLQASMERWICEVLARPMTDPAAIVALQRHVGEVHARIQLPIHLVARGARTLKQALFERL
DAACGHDDPLHRQAVAYVSELLDMALELMTEAFLRNSQRGARNDEAYRLFSLGQNMSVER
ERQRSVLLEWGQELMFSLHRVPRPGSLPRLGTSEFGLWFHHKAATLFEGAPEMEQIRDCI
ERIDATVLPRLAQPGLLPDEGTSLVLSLQQELDNLKFFLAGLFEHQLEVENGRDALTRLL
NRRFLPSVLNREIALSNQQGKRFALLLLDIDHFKRVNDEHGHDAGDLVLQQAAALLLNGV
RNGDFVFRYGGEEMLVMLVEVDAQASLRIAENLRQRFADNEFLIGQGRRIGLTVSIGVAV
YDQHPDPQYLIRRADQAMYMAKNSGRNRVWLAGDPLADG
>A0A8B3UBU1|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQMQTSSAWESFYVMSDLILARVSETLATEQSLESLVRQLLEMLEIVTDMESTYLTKVDI
EARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTIFSNDVPERWPECEAAKALGI
TTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQSIQKESLVTQLREA
NAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKSNAIIAFIDLDDFKLINDRYGHE
AGDQFLIEVGKRLTEEKQQDDIIGRLGGDEFLVASLSQPHQDGDNAQLTLLKTRLSACIA
GEYWLGSVHIIYPGASFGVIEVDPAATDPDSALRAADVAMYQDKKGKSKSRFLTID
>A0A517QS94|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus polymorphus|TrEMBL
MLEREFRLTHEGGAKEKSRQFLHTQLVGDVLSTVDLDEHRYLIVVDGLGAILGVVETEEL
LKKVASPDPVERRRWYEMPLESTISARLDSYSPGHRQQQQSDSTNPLNEFFGTTISSGDD
DLAAIFLEDELYLRWSSVKQILQHALVDPVTGLANRMVFERRLAEEWQRLDRVPSSICVI
LIDLDYFKSVNDQFGHAVGDVVLEAVGKTLQHQLRSYDLLVRYGGDEFAAVLTGCTASQL
AIPVGRIQSGIQNLSLEGYPDLPDLSLSVGAVTFCSQLQAESIDDLICKADACLYRAKDH
GRGCAFLSDLSSEDSTPVHVDSLVQSMI
>A0A517QQP1|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus polymorphus|TrEMBL
MRETTSRMIFVAVSAWLSICLLLAGWMPELDSTFRPLWLISGLVGLISSVGLSELIKADI
RAQERLLREYRQAAMTDGLTGLANRQALENSLKNALHEFSPQRNPLSLIMIDIDNFKAFN
DQWGHQAGDTALKTVSNAAVEYFSGKGCVARYGGEEFAIAMPSMSLRESIKLAEGFREYV
SRIGCKINDKSSSVTISVGVAEAKDREAPDELVLRADQALYAAKRNGRNCIHVSENSDTQ
SAILEQTLTELSLS
>A0A380ADQ7|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MKSYFLKSAITVLLLSGMVPHALALDNPKADELFKQLEDGQVNNVAEVEQTLDQIAQLLA
KDDLDRQARLRRARCWSFDANDNANIDAAIDYAVNQAQAAENQAYPEALTDFRLCHGWYS
QLKGNMEQAKADYDQALQQAYQLEDHRLIADARSLRGAMYSFQGNFAMALEDLLTAQQLY
EKLKLDYWGLYNLADLATSFRRFGDPQSALNYYRQLEQAYRQSGHEEQAYIINGEMAIAL
EELGDFEGAVAKFQQSYDYLKQQGVTVEAAGVSVNMAGSLLKLGRVEDAKQALERARPFV
TEQMGGFYSFMQLYSADVLLRQGQAEQAMAPLIKAEKSFRNINNDRGLAELYLLKSEVFA
AQGLWQESLKVLRLYIALHHELDNKLQSYRTTEMRTRFNADRMAKENQRLLESERLKEQE
VQILQQNRLLQLAVLVLASIIIIITAVMAFKQTSKSRKFQKIAHTDHLTQLANRRYTYHK
GEAMFNQARDSGTPFSLVLFDADNFKDINDQFGHDGGDKVLQHLASLSQTLIREQDLLGR
IGGEEFLLLLPETAHEECLKIAERLRQTIAESRPEGLVGEPRVTISAGVATLGEELQFSE
LLKQADDALYCAKKRGRNRVETA
>A0A380BTR8|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MKLAATAYVNSLLQLSLTTLCRLFVILPLFLPTTGQSQAAEDTHSDTAQQPARELVIANS
NSWKPFSYLNDAGEPAGILVDIWQEYAKANRVEVRFILTDWQGSLDLVRSGQADIHAGLL
WSQDREHYLDYAQGLLGIESQLFFSQGLLGTEPDGYLINGGEVGVVRGGYEETFVRQKYP
KASVLTYASNDLMLKAAFAGRLKAFVADLQVANFYLYTSSEPARFIPVRHLYSAQIRPAV
KEGQSALLEEIRQGLARIPDSEYQRILNRWMYVETVYPRYLLQGLLGILLLGILVYVFML
RRIVAARTAELEAANAELAHLAATDGLTGIANRRAFMDALEQACGGRGYDSLTLLLFDID
DFKRINDSYGHHVGDEVICQLTQMVVAILPEGSVFGRIGGEEFCILQLGMTEAEAKTQAT
RLLLSVDREPFATKAGKLPLSISIGAVYAKPCARDAQSVLADADRLMYQVKASGRNDLLF
RRI
>A0A379YJR2|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MDCQTRPNTQTPRSMSLGLPGIRSRLLLSFFLLAGLIVFFGGASLWVMERTGKAHIAELQ
DQKLLLQTIKANQMQHLALLKLKNNWPTYPSNEREAILDETRQRQQQIITTLSQFTLAAK
EYDEALALGQQLSVVSGQPLRAPHMTGMISAIDNLSLRLSGIGLTHLDAQAQKNSKSLMQ
TLLWLVLGSLALIVLSQTVAWAVLGRHLLKPLLQTSHKLSELAEQNFGGNSPNAVNRETL
KINHALLSLEAQMSALTSEQQQDELTGLYNRRSFNQLLKQAWHKAVVKQHRIGLLLIQSD
QAIASETLLHLAQRLLDFEISGEHFLARLQQSQLALLLPDRDPEACIRIAQSLNQFVLAA
NLRAKAQSPRLTVSIGVANIQPARQLGWDTLVFQAEEALLSAQNRGGNCSAGANQ
>A0A1V5XDL0|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin193|TrEMBL
MTKISRQFNISVRNIIIIVFIIMLLLSLSVIGYIVFSNWMSSADEIASDMAKELNERNCE
KINTFIHTPTHINEFYRELIEKEIININNEPEREKVFVNIMQTHSANVYSLGFGIENGDY
YGARRNQNGKIEIMKSNEDTGRHPWYYAVNDDFTADKIVAKADFYDPREREWYKAARQAG
APVFSPIFKHFIVDDMTVSAAYPIYEENGKLRGVLGCHILLSSINRHLRETVIQYGGIAI
VAEKNSGMLIANSLNRENFKKQMDGSIIRCTIDDLENPFITQIYNSYLNTGVTEYNLNGL
KSGIYGSISEYQTDGLDWVIITTLPKSIFISDIMDNMKTAMLFVLLALLVSLLSYLLVTY
KLFMPINSLISTAKNFSSGDLSQRATIVRNDEFGRVSAAFNNMADTIFKLVNNLEATVRE
RTAMLQDANTELNESREKLRLILDSTAEAIYGIDENGICTFCNASCIRILGYRSEQDILG
KNMHELIHYSYKDGRRMSIEECSIYKSIIEGKGCHIDNEVFWRADGTSFDAEYYAYPQYK
DGVIIGAVVTFTDITRRKQNDEQIRFLSCHDALTGLKNRRYFEESLKDVDNEDNLPISIV
FADINGLKMTNDVYGHASGDALIKKSAEVMKALCRESDTIARVGGDEFIIIMPNTDAAEA
EKIMHRIKTEFSNASVAAIRCSMSAGCDTKTSISQSIEEIMVNAENAMYKEKTLSRKTVN
SDMINTIIRTLHDKYPRQKQHSETVSDLCEKIAFSMKLPETEVKKFKRAGYLHDIGKIAL
SESIMNKKKLSEEEAEATHQHSIVGYRILNLFDDTLDLAEGVYAHHEKWDGTGYPKGIRG
REIPLMARVIAVAEVYDAITANTSSAPVSKKDALEKIKAMSGSYFDPEVVDAFIRVMSD
>A0A735KN41|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 16:z4,z32:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
STLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2L2JHS9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SGAir0187|TrEMBL
MNKQYQRVLVTTPHPLTRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSVSLLYPSVNIIEAVIGALLLRRLLPWYNPLQN
LNDWLRVAIGSALVPPLVGGILVTLLAPGPEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLINGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNLESARYI
AGRLIHAINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCNPDKNLHRGLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVTNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPKPLDLLLNTSYFAIN
>A0A6I2ILR8|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MIKQSTKELIAMPSFILPAGLGFLSFIFTLYSLELSLVGTVLAPLWFPTSIMMVALFRNP
VRQWPKIIVVCALGSLCASAILQPVHEINLGYTAINIIEALFGASLMRRFLTQINPLQNL
NNWVRLVFCSAIVPPLIGGVLAVWLAGPDGGNIAKTFFVWVLSETIGTLALVPTALLFKP
SYLLRHKNPKLLLETIFTFVITLTLSYLALRYMPWPFTFIIVFLMWSAIRLPRLEAFVIF
LATLMVVSLMMATNSTVDMQPHTDIMNNAPWLPFLMILLPANVMTMVMYSFREERKHITE
SEARFRNAMEYSAIGMALVSTDGQWLQVNKSLCKFLGYSAEQLRSLTFQQITHPEDLHAD
LQQLNMLVSGSINSYSMEKRYYTSKGDVVWALLAVSIVRDIDGTPLYLIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLGSDVISWDKRMFDLYEVPAHMKPTYALWLECI
VPEDAPHAEKTVRDALKARVPFKMEYRIHVKEGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNITFMNPIAEKLSGWPQQQAIGQH
ILAILHITFGDTGPVMENIHSGDYARTTIEHDVVLHCRNGGSYDIHYSITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFENHLKRLLQSAGENRQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELSSLMLSMLRTGDFLARLGGDEFGLLLPDCSSDNARH
ISERIIQSINDYHFTWNGRLHRIGASAGITQIDADNRIASEVLSQADIACYASKNGGRGR
VTVFESSQHEIRKEDQHMTVDEQKRIINENPILMVARGVAPPRVPESTSFYVVSLRFWGS
DNVVIDESPFRAAVTDKELQCALDLRVFNEFFSKFSQQVASKGFGIALPISSPGLANDKV
VDELLRGLSRSPLPARLLHLMVNCEVLQSYDEKIDSNLKRLRDSGCQLILSHVGRDLDIF
KHVSRQRFSYIIVDEELISNVHCNLMDEMMVTIIHGHAQRQSLQTIAGPADMPMVMDTLS
GIGIDLIFGEAVAQPTPLEILLNTSYFAIN
>H6RV26|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MRLESSLPLMSFEEACAEVVRYLKASVPLGFWSVSRQENGRQVYVSVQDDVYGRTVGDSH
GWSDSYCQFMVTGEAPQIAPDAMAVSPFAAAGVTRKMRIGAYVGVPIRAGDGSLFGTICG
LDPEIQPASLLDHAPVLRLLADLLGRVLEAEALRAEAEDRSVELRWLALHDQLTGLPNRA
MFLDRLQHAVQLHRRDHRPVAVLLFDLDDFKAVNDRLGHAAGDDLLVRVGERVLGALRAG
DTLARLSGDEFAVLLEDGGDPLVTGRRILASMREPFVIAQGSAQVTAAVSMGVADLAGHD
EPVTAEVLLSHADIAMYSAKRAGKHRIACYDPIMTLPGARDLALRGPLERAVGAGEIDVV
YQPIIELVSGAAVAFEALARWRHDGEDIPPDVFVPMAARADLLPELTAHVLEVAGAQLAR
WSVEVGHRRLRMSVNIPPAIIADPAFPDAVAGVISRHGLAPEQLVLEITEDSLLADLPVA
RAVAARLRSLGAGLALDDFGTGYSSLVHLREIPMQYLKIDRGFTGDLDTNPVTERFMRAL
LALGGDLGLDVVVEGVERPEQADVLRRLGCRYAQGFLFARPGPAATGLPAADLLRV
>A0A6N2Y717|diguanylate cyclase|EC 2.7.7.65|Clostridium tertium|TrEMBL
MRHRALITLRKSKTFIVMLIVIMCTIIFPKNVSAEENKIIRVGFPTVSGFTEKKYGEYTG
YAYEYLREISIYTGWEYEFVEKNIEELLEDLRNGEIDILAGMIKNEATMQIYDFPKYDSG
MTYTTLAVLDNNSFDESKYIILDGMKVGYLEKNVNGQKDFKEFCEENKIKDIDLISYSGG
NGRPFLLEKMKDGEVDAIIGGDLTVDSNENVIAKFGGKPHYFATTKGNSEVIEGLNRAIY
KIKDDNPYFDQTLYSKYFVNNYNNNLVMTKGEVNYIKHMKPIRAAYVDGLMPIQYYDEDS
NQPKGIFVDAMNLISERSGIKFDYVRAKTYNEAYEMMRDGKINIIIGAVNDYSIADKYDF
MLTKVYLDFEVLKVVNNEKNNNEVKEIIALPIGHDHLNLTGEYQIKYYNNMEECLRAVDE
GVVTSTYGNSYSISNYSAVGYYNNIKVIYTGEESEIAVGISNKMDSYARDILNKAVYSLS
DKDIENIAQKNTLNIKHSISIKDFFYNNLVLCLSIISIVLIIIFTLIYIIFKMRFNKIKE
DKQRLFEKTQIDSLTGVYNREACEKLVMEYLNEKDVSLYCAFIIIDIDYFKQINDRLGHK
VGDDLLVDFSKILKESFSNTDIVSRLGGDEFIVFIKDIEENNIGDIEETLKKVCKLMDKE
IEYNGINQRISLSLGCVMTKFNINFNELYTIADETLYEVKHNGKNGYKIKDIN
>A0A485C797|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKDYPKGPRPTFKRALRRISMISVIISMTLVWLLLSTASVFTLKQYAQKNLELTAATMS
RSLEAALVFGDSAAAEDTLATLGKQGQFSKALVLDSQKKHFALWHNHDLVSEEKLSGLIS
KWLFPQPTVQPIWHEGKMIGELRLTALDRLISHFLGISIIVLTGSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVISKLMNDDVTHRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMAFAGTDHQAWRLGGDEFAILLRNVHTEAEVQAQCALLSAQFLQPFNL
HNGHTATLSLSIGYALAWEHTSAENLQEFADQKYVSDETSAFTAGTKIKGIIMLRKYFAP
ALLAAVFLTGCQAPQGKFSQQQVAAMKSYGFTESNGDWSLGLSDTILFDKNDYRLRPESQ
QQIHSMASRLASTGITHSRLDGHTDNYGEDGYNEMLSLKRANSVADAWAEGASIPRSNLT
TRGLGKKYPIASNDTAKGRAENRRVTVVISTP
>A0A8F7R956|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESVSLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLCSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLPA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLVQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKNINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVSAIRENTEPRVTISCGV
SCWSKTGPMPLKLLVQQADEALYIAKRNGKNRLIIHQNSTTT
>A0A8F7NGB6|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MLKELFLNLTILITFNYLFTVLFKESLSHKEDRPMFQLLKGAVCGLLGVFLIAFGFSYSD
FIIDLRNIPIIIAALYGGWVSTAAAFIIIVAGRILINFNASAIYSIAAVGMIAILSVAVF
RGKKPNHKNAFVMLLFSNVIITLTLLLLMPEQPAGALVYFWLISTLGGILSLYIIKHEAD
ARLLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRASQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSDPSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTSDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A485BFC2|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSDFILARVSQTLANEHSLELLVRQLLEMLELVTRMESTYLTRIDLSAQRQLVMYAHNSS
EMTIPEGFSVPWNESLCKRAIDDNCLFSNDVASRWRSCIAAQELGITTFFSIPVRLTDGS
LYGTLCATSRQRQPYNLEGEQVMGLFANLISHYVEKETLVEQLRAANSALELHSYTDELT
GLPNRRALFKHLSTMFPRARELQRNILLIFIDLDDFKAINDRFGHPCGDNFLVQVGERLN
ARVRQGDLVGRLGGDEFLIIGAGLEAEEQQAFIAALRKELGGIYFLAEHRISYPGASFGV
IDVDPQTMDMESALRAADDAMYQDKKSRRKETFLDID
>A0A4U9CXE8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MRDAQVVTASVPLDFRHYCTACWRWTFPVREMKTFLVNAAKGGQDGEYQLYDNRLNLIAS
SAPGNVLTLLSPREQETLSYAFSHDNKGGIRLLTRYISWEKLNNFDGVLLRIHTLQEGVR
GEFGSITIALMLMWLLFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGL
FERAIAAAGECERGKRPFAVIQLDLDFFKRVNDLHGHQSGDRVLSLVASTIASNIREGDL
AGRVGGEEFCVVMPNTTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVSSSEDRA
EVNFENLQSIADRRLYLAKQSGRNRVCSTG
>A0A7L6XHM0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C05|TrEMBL
MDKDLSRTTRPTFKRALRRISMISVVVTMTLIWLLLSVASVLTLKQYAQKNLELTAATMT
HSLEAALVFADDAAATETLAALGQQGQFSAADVRDKNENVIASWRYNAQETDDKLSGYIS
QWLFPLPVSQPVWHNGEIIGEVRITARDSLISHFLWLSLAVLTGSILLASGIAILLTRHL
HNGVVVALQNITDVVHDVRTNRNFSRRVSEERIEEFHRFAQDFNSLLDEMEEWQLRLQAR
NAQLLRTALHDPLTGLANRAAFRSTINALMNDDAARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVAKRLAEFGGNRHQPYRLGGDEFAMVLYGVHSEYEVQRICAALAQEFNRPFDL
HNGHLTSMTLSMGYALTWEHASAEKLQELADRNMYLAKHQRVERVIK
>A0A4U9CWR1|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MGFASLLINFSNIVFIVTLAQLVLWDKRRADSMPGPINALSLFCYCLLAALLCAAVGALG
SVDVERATFIPQLADWFSEQFSTAVLILPFILTLTLPSALGAFRFRQLLPVIALVLSIIL
GVSVGGAGSITFPLPALIWCAIRYPLPLTCLLTFITGISEILLVANSLIHLSPDARMQPW
QLFSTRLGIAAMLISPVIVASSVEAINNLVKQLALRADFDFQTRVYSRSGLGEALKRQPL
AEGQLLTVMVLDIDGFKRVNDSWGHECGDCVLAQFAQQVRQLAGEQGMVARIGGEEFAVA
TLTSSMQESQALAEKIRQGVEAQTFVWGQNQIRLTVSMGLESRPVGNERITELF
>A0A399EAR2|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MTLRQPETSPVLDELFRQAAAWREENPKEALRLYRQALELAQADACFTGVAHALRGAADC
HVLLSQYEQGLALALQAKAAFEALGDRAGMGHCLVHVGAVRMYQADYAAAHACFGEALEI
ALDAQNTWLEALARNNLAWVFSTLGNFGFALEHYLKALELFRAVADPAFEAMVLCNLAAA
HLELEDYDQALEFARRSLELRQQLRLRLGQADVHNLRGYIYYRQKRLGESIAELERAIAL
YDELGDRDYQCASWNTLGQAHLALGATRRALECFGRALELATLSESPSSLTDAWRCMAEA
HLQAGDPLQALADLERALQLGDDNLSLRREVLETQSRVLEALGRFEEALQAHKALRRVEL
RLKDEQLQHQTLALSMRYKLEQERQRSAELAQVNAALEALNQEKTRLLEELRRQAELLER
QSLEDPLTELANRRHLEGYLHQEFARVRRTGRPLTVAVADIDNFKSINDQLTHPVGDEVL
RVVARLLQDGCRAGDTVGRYGGEEFVLVFPDTPLEEARHVCERLRQAVEGYPWHSIHPDL
RVTLSFGLCDDTSGPSHEPMISHADALMLEAKREGKNRVKTPPGGSR
>A0A399EYZ1|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MKAQPRPNPVTALSKSELERRLREATMLKQIVATSGAPLEPLTVLNVICSELVEVVGVQH
AGFARMSEDGQYLTVVAEFGGEHRTGLNDRIPLKGNVITQKVIKTRRPVAVLDAQNDPRM
GAGREAARHFGVVSMLIVPILAGDRVVGTLGLDSYEPRRFGRSEVALVEAVSRAASPLLE
NAHLFDQLKTELAERQRAEEELRKSRTLYQELVNSLEGVVWEAELHKDSLVFTFVSRQIE
RVLGYGMSEFLGPRERSVWPRVLYPSDFEQVAQRLRTLAITLETAEVEYRALDKDGRLHW
FQDRISALREVDGTVRLRGLIVDVTDHKRAVRLERDRNLALELIARGAELEDILEVLVEM
LAAQLPEVACAIQVLKSGRVRFAASTNLPETLRRFFEAGATGPLGYRVQEGEASAMPDFE
QEQRLDDPARQLLLRSGYRSALTLPVTSKEVVLGALTVISPSPLEPDVRAAHIVADLAAI
AVDRQGLIEQLEYQATHDPLTKLPNRMLYQQRLTQAMQRAEEKGRLVGVLYIDLDNFKKV
NDTFSHATGDELLRSVARQLAAAVRPGDTVARLGGDEFGVILADLPSVQMAERIARKLGA
EVNTSVRIGNRALEVTASIGLALYPRDGTDADALYRYADREMYAVKGKPADKAPPAAEGQ
>A0A517R7T8|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan189|TrEMBL
MSSEPSFELPSLNEPVATEVPPAPKAGATHPTDSAGTLLSLMTLAKTARLDVNDPSTDEA
LAGVIAPATLRALLSALNHRDPKTIRHVRRTARLATGVASAFGWDERPLKALEVACLLHD
IGKIGVPDSILFKPGALTGDEAELMALHHNIGCDILQACRVDSEVYDIVVQSSQHYNGAT
DGYRLIGSDVHQGARILAVADAYDSLRTQQVYREAIPHDEIMKKLKAASGTQFDGTIVVA
LGRWIEQEGPGVFDPELDGGSSGREHPNAPGMLDPNALCQIFSHLYILESLYDGFYLLDA
DLKVVLWNLGAERLFKKGHQEVLGTNWNARAWEFADLMGNPLGEGEYPLQRVLKEPRAIS
SGLKYKRFDGKWTEIEIQSIPLIDGNGQLQGVAEIYRDLCRTTFRPNEYRELKMAASRDP
LTKIANRGELETQLALHLSEIGKQQDHQPFGVIFCDIDFFKAVNDNYGHQVGDDVLVNTA
RLLQEECYSGELVARYGGEEFVILCPDTDLEGAVRRAERLRGLLAKTVLNDETELKVTGS
FGVSVYEKGDSVESLCRRADKALYQAKETGRNRTCSITSTQLHEDRRKTPDEPIETDPFL
AEGHFEAQLASDMIVYKLGGFVDEISAKVKDVTQRQATFAIGTTGMFGGWGKSSQKQAVQ
LVLEFGEDRRASRPSNSGTEVRYRFTPIGRPPSPEAFHRRVKELLKALRGYFGVQ
>A0A654D527|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MSLSSQRVTQRSLQSLLLKRFGMAVATYAMTGLLCWAAVFAGLFHASPLTALTITALAAA
SQLVFLVLFLSHFNLRLSDPSLTEPQVLVALAWLTVLLSLFSEGRGSMLVIYLLIMLFGV
FQLPPRVFARCALFAFFGFAGLNLYEAYTLQLNEPRAAFMQACVLAVVLVWLCLFASYAQ
AMRQRMRQRRFALQAHQDTLRGMMRQLEDLAATDELTGLCNRRHFLRLASRELEGLHHGR
QHGLALLDLDHFKRINDIHGHAAGDRVLQTFAAVARACLRDGDVVARYGGEEFVLLLPNT
EADQFTACCERLREAFSRAEPLGVKVASLSVSIGMTLLTVHDDLDEALQRADQALYQAKR
DGRNRCAATWEDVDA
>A0A1S7U7P0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense NCPPB 1641|TrEMBL
MALLLIAQFIAFSLFPLYFTTLPAPSRRTHFYTYIALILLIGGFMGNVYSLPIADGVVVS
GGNLCYGAFMMASVMFVWVERDAFILRHLVRLVVLVDIFNIVFSLLTHSILETDGVINPH
AVPSGLFEISTPMIALGGVLIISELLLLLFIFEAVKKKQSSLFVTAAIYILSFVLVLVLD
GIAFPFIAFGINAQIVAIVIGGLAGKILIAFAYGMPLALFVLWKRQAFIHYLETDTVRWR
LLASSSADLIKEMTIKDQDVRRGDIVFKNSTEGLAIVNHLGQELKANAAFRAMLGINYDH
TGQHDTDIDKSFWIDGRPVSRPHGAAGQWRQEVMFGADRHRPGILSITPAGEDASGGDTF
VYSLTDITDQKTAQAKLEYLASHDHLTGLPNRRTLDKSRARFQNVPHALIIIDLDYFGDV
NDSYGHGVGDRVLQLIAERLDNLRENYLASGDVLCRLGGDEFAFLIQSGDHGFIEGIIEK
IQSCLGQTVHIRDDLEVLSSATIGVSYHLRPGDHDTLLGADAALYEAKRSRRGSVGVYED
RLTAQSQKRVKLGLKLKNAIANSELDVYYQPQFTAVGHELHGVEALVRWSDPELGVVSPA
DFIPVVEETGLIETLGEYVLERACRDGQEWLQAGYLPVTLSVNISASQLRFGRFIPFLKG
VLSETGFPARQLEIEITESTYIQRENEVSPLLNELREMGVGIAIDDFGTGYSCLSYLAEF
PCSCIKIDRSFITDIPTDTRQCSLTSAIISLAKGMSFKVVVEGVETREQLDFLTKHECDL
IQGFYFSGALPKAELAVLLRRSSMPSGDNFVS
>A0A1S7U2B3|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense NCPPB 1641|TrEMBL
MNEIIDTNVFNLAPVAMWIEDFSEVKSQFDIWRSQGVEDIRAFLLEDLSRVAACSQKIRV
IKVNARTLELFEARDQAHLIDNLHRIFRDDMLESHVNELSELWAGKTEFTSNAVNYSISG
KRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKELLNRRYAEGMFKHSPVSLWVE
DFSRVRRLIEEVRDRGIVDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLTHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDELNRLERSALRPVSAIVIDLN
GLKDANDKLGHDAGDALLRRVGEVLNGVVTAPNHAARIGGDEFAILLPGADRQIAAAMVE
TVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRADMNMYEQKNAYYAALRSRSA
DNNDTTKLDPQSEASSLKRLS
>A0A1R4L847|diguanylate cyclase|EC 2.7.7.65|Vibrio ruber DSM 16370|TrEMBL
MFSMSVSSSWFRSLLPILFIVAIHIGMGHEIFTQLSNSNVLLNLPYVLLFTALAVAQIFK
QSRMGMLAIAQILAYAIIQLRLQTPLISGSTLLELSLLALLFPISCVICYAFHDSDLFTK
EFLYYLIIQCLFFVWSLLILDYFNQGDFPDLFTQLLSSVPQVSRLPFILFLYLIVLSGIT
MLLLLRKNRKLDAIVYTSVLLISDVFVSFHMPHISSILFSISGIFLVLYVIAAGHEMAFH
DRLTLLPGRAALDHTMKSLGRHFTIAMIDVDHFKQFNDNYGHDTGDEVLKLVASKLRQVK
GKAKAYRYGGEEFTIIFKGKSTEEAFDYLESLRQEIQNYDMYLRNTDKRPKSDKMGRLKR
QKDQPSNVVNITVSIGVSDSRSSRNPQEVIKSADQALYKAKKSGRNRVTV
>A0A5C6EYQ3|diguanylate cyclase|EC 2.7.7.65|Candidatus Brocadiaceae bacterium B188|TrEMBL
MKSVEENKKKYVKSNMSQITKKLPPVWDSLFQAFEPITPGLSRSYDKLLQLFTMLNKQKD
LFNTILSNMKDMIFIMDKENKIMYMNKAASDEYGASLGKNCYRVICNQEMLCQQNGMENV
FKGQTVQLERTIKGKVYDSLVAPFVYGDKDLYKMEVLRDITGRKQLQNELEKLSITDKLT
GMYNRRYFDDVLEKEVVRTRRLRHDLSLLFIDIDKFKHFNDVYGHAMGDKVLQCLANLIQ
THIRKGIDVPCRYGGEEFTIMLPETSNGRALIVANRILKGFRNMKLRIPRKNESVKKTIS
IGIAGINQQSNLSIKSLLVHADKAMYKAKKLGGNRICG
>A0A8D9P1J8|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MKKVALFMDGWKRYFTYAWPLGFMQKIKEARADVNLYIFNSNGNWNRDDGYSYGEYNIYN
LPELTDFDGIIISVNNIKYPEVTAELLDRIRKSGVPAISLETAFDGLHFVGIDNYDAMYD
MTRHMIEKHGAKKVWYLAGPKDNYEAQERCRAFRDCMDEYGLTVDDEDVLFGDFGFNDGV
TGFEELLRAHGHTCIKHEKDGPDYGGPAEVYGEITSGSFADSAPNAEASNNDEMDDRRLE
EREIVKKILPDAIICANDNLAVGVCNRAEALGLSVPKDFKVTGFDNFDKAAYYTPHITTV
SRIREKIGAAAAEIMLNIWAGNNPDTSSYIDYNCIFTESCGCGTDAMLNGRQYLKNYIMG
VVEREEIDESTLDFTHLLSKCGDYSGLYPCVQTAYSQAECKKCVMVVDRSLVEMGEAGPT
LSAAYDEDVFAVKGYPQRMQIVYRQGIADDGDDTYHSMFPLLDDETGGNIFLFAPFHFGE
KAVGFCCVENGYYLMDKQLWSTVMSEVNVAMINLFNKWRLEQINQELTAISIKDPLTQIY
NREGMRQIAAKAFDKAAGQGRALLIMFADMDKLKYINDTYGHEYGDKAIRSAARAIAGGG
GISSIPVRYGGDEFVSISIYDETESPEERKTAILEKAREIATQEKLPFALEFSIGYVITD
PDGDKTLEEYVREADHSMYQEKIQRRVSR
>A0A3N1W4V5|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. JUb26|TrEMBL
MQHEIDRYISVILNEWIPLRASLREDTVALLSQIAEAESEALTSQFYDSMLKDPDTASHL
SYELVQVQLSRSLIKWLKAVLCVKTDELEPLARQQYHIGGVHARIGIPIQFVQRGSRQIK
YGIYQYLKAHDADRAVIFEVKHYSSMAIDMAIELMSHAYAMSHHRATQNEESYRLHVLMN
NSDLEQGKQQAALSSWENGVMYDLISGARKTESLISLSSSGFGLWFRHKCVKNFGEDRKV
SEIRQFIEVIDREILAVDTSVELEVKQTQELLRVIHSNCQQIHMNLEMLFSDAANMKDGK
DALTNLLNKRYLPTILKHEVSLAIENKLPLSVAIIDADYFKKINDKWGHPVGDRALMHIA
GLLGDNIRSSDYLFRYGGEEFLLILVEAGEFDARTSLERIRRTITSTPFEVLPGETIQIT
VSIGYAIHNGHPDYNLLLKNADAALYTAKGNGRNRIERF
>A0A5R8U987|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1V5PWX3|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MAKHFDSVYYVDIESGHYTEFVPMQILKEAGIPRQGEDFFRETQENASKCVHPSDLKLVM
SIHDRENMKKHLSDSYFYSVVYRLLVNGMTTHVRHVEILCEDKKHVICCLENIEGEVRLR
KQHELELQSARRMARLDELTGVRNKNAFMEYIATLDDKIRTEGKNFSFGIVMCDINDLKL
MNDTRGHSFGDEAIQRTGRMICGTFRKSPVFRIGGDEFVVIAEGEETDQLQELTERLKEE
SAANKRTRSGPVVAIGMAVFDPDTDHNVDDVYKRADGAMYEHKKVLKAARSRGCFVETDR
HKTPITDERKRLLDGMFGALTTISGGGYVYLNDLRYDFSRWSLPLVDDFGIESEYMYRAD
KVWAEHIHPDDMEVYKGAVEEILNGNGEIRPIRYRARRSDGSYVTLATRGFVLSDSNGDP
EYFGGIMIPQ
>A0A679JQM8|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MGALPSILDPRSIIVLAGIMGLMMALVVFFMRRSYPPSIRGLGEWALAPLVAFASTMLFA
GRGFLPDFVTIVVANFVLFQACILYYAGSQKFLLGRSDTRGWTILNGFLGLAMFWFSAMR
PDFEIRLVLVTLAVSALFFFHALLYMRHRGEVFGKRLMTGLLLVQSMVAALRFLSALAGM
AGESLMDVSWIQSLYISMYSFTVLLLSISVILMATDRVHTEFEYMATRDPLTGALNRRAL
LDACRAAFASAGRRRAALLMVDLDHFKEINDRFGHLTGDAVLREAVGRMQRAIGDAGLLG
RYGGEEFVVLLPDANQADAMNIAQRLKQAVGEPLAANSPNAAGPSDASESPLAAVGSIAV
SIGVAAGEAGQRVDDVLARADAALYRAKALGRDRVMAAA
>N9HEU6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii ATCC 9957 = CIP 70.31|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1T4M6Y6|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MKKKQKDINKHSILVLKTFSLLFFIFSSFYLIYNIYHLEKFQRRYIARIQNVYSYTRRFG
SYYNNAPEEYKIKNHYKTNNVSLIVNTTSNVKTLSSGIEKLRLQLNRLTDNNIWTIAVFE
NPADYAHFDPIRPQYLTQFDEYGENSVMHRIVQRENLENTYQSFYGCNLKLTESYTETGS
KVEIRTLYYPIYNNKHLDALIAIDIKNDILSNELQRYNDTHLTILNSNKTGNIYKIEELL
PCSQLNPINIGISLFSIFKLAFIPALILSFLSNSFKRYFIKKRYAIQRDHMTRFYRRDFY
EKKLLKQRNFNLLIIDIDNFKKINDTYGHDMGDEVIRHLAIRINNCIRKKDVPIRWGGEE
FIIYFPKIDRQQLHFKAQKICRSIASLPILNLNVTVSIGGISATNIYFNDAYKGADKALY
HSKNNGRNQYTIA
>A0A1T4R9C5|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MMLSNCYFKFQPRYYNGEISSYEALLRISHLEIEHYIESITDHVEFDLAIIESIIKQRSL
LPNPEKTQLAINISIASLLDDEFIEACKKIFEHEKNIVLELTRHDTTNDFARIQAAIKQL
KAKNVQFALDDYGKGYANSELFLHLDIEYIKLDRKLIKNISQSYVAYSLVKTKYEKIAKV
LGKHIIVEGVETFEQLNLLKQLGDMTYQGFYFSKPLDIGHIKPTKTNLDICKVDNPSFCN
VLDQAIYEMNRAPNPQAIKAAINHLIKIDRYNIIGISPNFFDVYSEQCRINKNYNELLER
KSSPHFLLVSSLLNTCNALVIMRDSDGNAIYNNEKHINYLGVDLVDYTAAQACEKFPDYR
TCLDLDNELLNSDTCFIVSNETVETENGKQFFHTYRQKITHFDQVFIICSVYEANDSIHI
DTLTGCYQKSYLKSTYASAYQTLVFIDLDGFKLINDIHGHNKGDEVLQDFSQSIQRMLRE
RDVIVRFGGDEFVLLLDSSSLNAVQQRIEIIRDNIEAYFLAKDLYLSFSYGIVDVNDCIE
SALKKADEAMYKQKYARKQ
>A0A2P6JTB9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. MYb185|TrEMBL
MPRLSLDELTAEWQHHLNSVPEQIKQLTAQLAVQHKTELATHFYTAMLQHPEAAMFLSHE
EVKSRLSSSMENWVCNLYSSQDTTDIQSVIAHQNKIGEVHARVSIPVHLVLRGARLLKHR
LAELLGATLTPQQAAMATNFALPLIDLAMEIMSHAYSASHDRRSRAEESYRLFAITQNIA
SEKEKQRAALLDWENQLMFDYAMSMTADQLPRLRSSEFGLWFRHKGTHGFEGAVETGLIL
DAMAQIDDTLLPLFALRANADPQKNLQLLRDVREQTKSIAYHLDLLFEQNNELESGRDVL
TRLLNRKFLSVVLNKQISYARDTSSSFAVLAIDLDHFKHINDTYGHEAGDLVLQQFASML
LNKSRAGDYLFRMGGEEFLMIMVDVNANNARRAAEKIRMLTAAEVFRLPQDVTIHITASL
GLALFTGHPDYQQLLRRADSALYEAKHSGRDQVVVAPD
>A0A6N3EDT1|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLKKLLLLIIVITSIFTSCIFSFGINAIGNDNRTIRVAYPIQKGLTEIDEQGNYFGYTY
EYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENGEIDIMGGMLYNEPMQKIYNYAGN
NYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVIENSDTRLKELDEYCKMNLMSPELVY
CKTNDEQLEALKSGKADVLLNVSMNPIEGVRTVAKFSSKPFYFITPKGSTNLTQKLNSAI
NNIEQKDPYFSTTLYEKYFTPENNQMFLSDEETNYIKETEKLKVGVLLNKPPFQNIDKDT
GELRGISIDLLNHICDKTGLEFELVPVKSQEDLENMTKKREIDIVAGMIYDYEYSREHNI
AMSRPFLSTQYTMMINNKLNENSLDGKRVALAKGINYYGQFEENIVWYDNLEECIEAVNK
GYADYTYGEGYSMQYYMNQPKYKNVRLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISI
SSEKMQSIVYQNTTYRQDFSLLYIMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEK
ISLELKKHTQLYEMTSEYFFEYDYKQDKLIISMPEKGIETYYGLDKNDKESENGNIENER
DKIRKEYNKKFFDVIKSQENGTTEMYSIMLDDTFHWIRVTSKIIYNDRKIPMYVIGKICN
IDSEKEEKNRLLDKAQRDSLTNIYNAAYIRKLTAQNLLNLSTEKNGALLIIDIDYFKSIN
DTYGHLLGDKVLIDVAKVLDESFAKNDIVGRLGGDEFSVYINDIINKEELINKCNDVYNH
IHLIKLPNGESLSISMGVVIAKPGQEYDELYQIADTALYDSKRQGRNRFKIV
>A0A4R6EBE4|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. JUb87|TrEMBL
MFGDAIQREISRFKSPGKVVNLCFIVVFIFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHNIDSLLFYRNTMHYALQSPISTDRTRKSLAEFDLFRTQPFWQLRLDLHRSLPM
NGVSDEFVNSSPLLERDDETLHTELSAALELSYIMRLSDRSRTLPQRIFYASRSGFFLSS
TAPVNDPKIVSLYYRLIAQPYFSSQSPQNNPSRVLRWTHTFNPNSTSGQIITAAIPLDFN
GRWYGVLALDYPIDSLHSFLQQAKYDDHEGTVLLYDNELNPIATSAKRMPKHALFTAPQL
AQIANAVTVAKPGEQGELRLDTRFITWAKLNNFDGLLIKVHTLEEGVRGEFGRISIVLSV
LWLLSTLMLFVSWMVIRRLVSNMFSLQQTLSWRANYDTLTRLYNRGAFFEIANKIAQECK
QQAQPFSVIQMDLDLFKSINDRFGHSSGDKVLTHAAAMLSDAFRQGDVAGRVGGEEFCIV
LPDTTLEEAVKVAERIRVRINSKELLLKQGNTTRISASFGVSSALEFNDYDFERLQSYAD
HRLYKAKQGGRNQVCSHD
>A0A6N3EN61|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNIYMSLLVVSLCFLSYYLYHYNFFKYLDIMINNSKNKYKVYIVYSLFNYLIFIICTYLR
LHLVINWTIFMLILFMQIKVTYKLSTIKNLFYSLNCSIIGLAINIFFRSLMSIVLNMPAY
LFDSNSITNIYRVFSILLSFIVTGLYFSYKNHKNNKINFEAVLEDKKNLIFLLSLMFGMY
LYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAERYSFRITQIKGYDIKNQIEYVE
SVKTEYEINKLNDIVYTDLLTGFYNRPFVNQKLSEWTSNHYKFTLCFTDLNSLKPVNDKF
GHQFGDKYISTTAQIIKKLINVENSLLFRYGGDEFLFLLQNTSCVEAEKIMININYELSK
LSNTDEYPYALSISYGLVEWDGISDIETLISKADSLMYENKLKNKSTLN
>A0A654D4Q9|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. AX6|TrEMBL
MWGRVIRGVWLAVIAGAIMLGLSVPASAQSRYIGDKIDVCVRPADAPGLDPKRLIAEAAT
FDCASPQRSFPSGDYWVVSKPLSARSSEGSPLRVRTSSLFQGSVTLDIVYADGAIVRHRA
DGRQMSSRIQLGAISQFEVPPRDAAVTRLVWRIDDASNLHGIVLGARLATAEDAAQANLS
LGALYAGFAGLAIALIVYNLALWVVLRQGFQLAYCAMAALLLAYCFTSSGALAWAWPDLP
NNDRIRLNHALLGAAAAAALVFARSFFEREVFLGWVGRFTHVATVAVLGGGIVFLLAPDT
HIGQADSVFAWGFVGVLAVIGPMLWRAWKVKSNYVWLFAFAWAAPVVMAGMRFSQHLGLI
PWRFWIDNSTIFALAFEALLSSVAIAYRIRLLSNERDFAVAQEAVQRKLADTDPLTGLLN
RRAFLDQAIGRGGMQQLLLIDIDHFKSVNETLGHDGGDEVLRVFARVLRQVVPEGGLVAR
LGGEEFAVLAPPGAEIDPDALLARLRAARMPFDLDVTASIGLCRGGMKREADWKSLYRAA
DRALFDAKAAGRDRVRRSETLLAEAA
>A0A1N7QWB7|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. MFA1 R4|TrEMBL
MSSSSTDVPPSPAGVAAPSGQDCYLSASNAQAWEAVYQSVDPYTRGQVAAVVADSATQLV
DAFYSTLLADAEAGPRLSHEIVSTRLHSGMKHWLHGLLCVRDQGDIDVLMATQKKVGEVH
ARVHIPIHLVMAGARVLKNEIAQRLRASDLDGKAASVATQYVCNLFDLAIEQMSRAFMRD
INRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAASEFG
LWLQHKGAVLFESAPALRQIMDAVARLDDTVLPRMMHGDAPGQGSLPDQVRELQELVARI
KHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISIARRQRSDFSVLLLDIDHFKA
INDEYGHSGGDQILRQFAELVHQTCRSSDFVFRYGGEEFLVVLVDTGGEAALAAAKKLNA
EIRRHRFTIAESGALPVTASIGVATFDGHPDYAYLIDRADQALYRAKQAGRDRSVAA
>A0A8J8BJ30|diguanylate cyclase|EC 2.7.7.65|Silanimonas sp|TrEMBL
MSRLPTDIIPIAGTFADAAALAAGLTSSTGIMIAFFDTGHRIAWANERYAEWFGVTPQAL
VGRSVVEVYGREAYEEASPRLQRAMAGEPLRYERLLEKPGSPAKWISISLCPHRDAEGTV
LGVFGCSIEVDELRRTRDALDRSLQEIAIYLDNSPLAVIEWDREGRIRRWAGQAERIFGW
ASSEVVGRNAEELSLVHPDWIVTTGAAMRELRSGHTSRNRLVCRNITRAGLPIYCEWFHS
AFIDREGTTQGVLSLAQDISARMEVEEQLRHAVVHDALTGCYNRRYLMQRIEQAIDAVRP
DENGPALLYLDLDHFKPVNDRFGHAIGDDTLKAVVERLQACARDTDCIARVGGDEFVLFM
DGPVDRETTARVRKRIEQCLGEAFRIGGHELQIGASIGVAHYPDDGTTADLLLRHADQTM
YQVKQSR
>A0A1I9YGL5|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sprentiae WSM5005|TrEMBL
MNGTTLRQVAGPVSFVLIVLVCWFVAGMVADRMVQQELDAALRAQRQMSTSIVDNMAEVI
ASDLAMSRAIPATMAEMDVVQRALVQSQNYAANSEAAEPAMRAALLKDPKMAAVSKFLHE
AQGFSGLDQVWIVNANGICVASSGTMSAADGVQQSFVGVDMRARGYLTNTLLGAFSEAYG
VGRASGEPGIFIAAPVYADGLLVGAVVAKVGIARLRHWVAHAGTFVSDDNGVIIMAHNSA
LEGHALPNSPVTQMGPAERRIIYRRETFPDMLIREDTQVREQAPWVPASVAAQLFGMSEQ
PAPALYQNRGGLNSGLSAHLVDPLAAWPELLRNHKRDHLLVFLTLAGTVALAWVITVSYV
RERRHHRATRDLAEQLQSANTLLSAEARHDALTGALSRRYFLDLLRHEIDRAHAGREPLC
MAIADLDHFKQINDCFGHAAGDRALEHFVDTCRAELRGSDAIGRLGGEEFGLLLPATDLT
SGREVVERLRLRLKAVPSPKLPASVELSVSIGITELSPDDLPERLMSRADTALYAAKTGG
RDRTEALPPDDTAPPTRTAVNAW
>A0A0D6MQP8|diguanylate cyclase|EC 2.7.7.65|Tanticharoenia sakaeratensis NBRC 103193|TrEMBL
MLTELAPHGAPATADEWQKRLARVAPDIASLVASVVESHADACVETFYSVLLTQPDATDF
LSHQMVNTQLRAGLHKWLLTLFSRKTPDANVLVATQARIGAAHARIHVPIHIVMQGARLL
KGVIRQFLFERDLSRDTLFRAISHVGDMIDIAVEFMSQAFVQDLQKGAVADEAYRLVSLG
QDVTLEREIQRSALLDWSHKLLFNLWDATPTSVIPLEKSDFGLWLTHKGNVLFQGTPGIE
QVRVIVSRIDAELVPALVKSKPPASALIQNLQTTVNEIRFLIDQLFKETEAVEGGRDPLT
HMLNRRFLPTILGREVKLSLHRGTPFSVLMLDVDHFKAINTTLGHSGGDSVLRGIAELIV
DACRVTDFIFRYGGEEFLIALVETDREGAWHAAERIRQTVEQNTNTMGWGEDVRVTISIG
IATFDGHPDYTHLIEEADRALYAAKAAGRNRCVASTETCIQSEA
>A0A1E3H3E3|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MLGTAIRHAGTSAIIFAVLAAFGIAVSREAGNVAIFWPANGAIVVLTAFADRRALLPILT
GAALANLAVQLAYGDGLAFSLGLVLANGVEIAICALLVRIVRRNGPPHGLEDIAKVIGAL
VAGVVPAALLGGSIVAVTFGKPAASCMLTWFMSDLASALVVVPPFLTASRRNWDDLRHRL
ASRDLVLLRDVAILVLLAALAVLALPLHDLQVVSLFALPLLWSAIRFGVFPTAAISSFTA
LAVIWLIHAGRIDVMLGDSLAEEVLFAKTALVLIALPPLFVAAAIENTAAVNRLLAEKER
KLSLVLDSLREGLWDWNIATGEVAFSERWLEIVGYQPGELPGHVTTWHLIGEPSDQARIQ
ILLQEHFAGNTTYYEAEQRLRHKDGHWIWVLDRGMVVERDRDGRPLRAVGTISDIRGRKA
EEAELRRRAHQDMLTGIGNRAHLEEMFARRLMSGDRGFSLLLIDLDRFKPVNDNHGHDAG
DHALKVTAERIRACLRPTDVVARIGGDEFAALVETPPSGNLSGIASRLATAIGDEIAYGE
TKIRIGASIGYASVEDVGTSFAEIYKAADERLYMIKRREDPASAGSRSLAPT
>A0A8G0ULT3|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MASAKSPSEIARETLKLLATRRLPPTPDHYQALYDEVAGTTSAPAFPSAQLRQISRVIPG
QTPAQKRLLGLLETAITQQDWGVLQNVLVGYANLGLSPVAAPEPASTRIDHLPLALAQNL
ARLVDNTLPALGEDDARVHELAAQLSTFLREPDPPVSTAELMLGNFSYRLSFAAEDQAAI
RLSLLSLLRLVFENIAALSMDDEWLHGQAEALLAASTPPLTLRRLDDVQRRLKDVIFKQT
EAKERTVHAQMQMRELLATFIERLAQMDESSSAYNAKMEDCAERISQATQLQDIMPLLEE
VMAATRAMALSSRVTRGELQELRERTEAKHAEIDHLRQELDRASAQARHDPLTGSLNRKG
FAEAMEREVARARRQDAPLCVALLDVDNFKSINDRLGHTAGDAALVHLAQVTREVMRPQD
QLARYGGEEFVIILPDTELAEGVKAMERLQRELTTRYFLKDQERVLITFSAGVAQVEGEE
GSADAIRRADQGMYLAKRTGKNRVVAA
>A0A2X4T4Z4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLITMTLIWLLICVASVLTLKQYAQKNLGLTAATIAH
SLEAAMVFSDNAAAAETLAIPGRQRQFSAAEVRDKNGRIIASWRYDAQAADDKLIGLISH
WLFPLPVSQPIWHNGRTIGEVRLVVRDSLISHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDQRIEEFHLFAQDFNSLLDEMEEWQLRLKAKN
AQLLRPLCTIR
>A0A7H4PR60|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MQAPGIPENEEQRLKSLYITAFLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A0F3Q1A2|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum str. CRT53-1|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLIKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNLLQESF
QETTILSDPTQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSVLLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMYFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>A0A5H9VJL1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5P9INS8|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MTTLPVKALRRRLLLAFGLIATVCTVAIAYYAVQARQHVGADYTSMVADVVRSQSDPQEL
LMALARLEDDHPDHHAHQDELAELLLRIPRRIMNLRVQILRSDLPPQDFTPLLDEMSLMK
ERVETLLTRFSRARRDGLDAEEIDALRELGFEIEVGLAWSYSELSLLVQNASAGQRQLMR
RLTLAVIGLLVMVLAAVGAVMLMMLRLQRQRDMMRLQSQTDMLTGLYNRRRLQEVAEREF
ARRRRHPSPLALMLIDLDHFKYINDTYGHPVGDAVLSSFAETLRQQVRGLDTVARMGGEE
FAVLLPNTDRRAARQLAERILAATRAMALPDAAADHRITVSIGVSEARHDDSFEHLYSRA
DRRLYGAKTAGRDRVVSSDALTGVPRGDASPDEGRDAPERHSAS
>A0A7H4NIQ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MQPWQLFSTRLGIAAMLISPIIVASSVEAINNLVKQLALRADFDFQTRVYSRSGLSEALK
RQPIAENELLTVMVLDIDGFKQVNDRWGHECGDCMLAQFAQQVRQLVGEEGMVARIGGEE
FAVAALTSSARDGVLLAEKIRQGIESQTFTWGQNRIQLTISMGLESRAPGSARITDLFNQ
LLMVADDSMIRAKKAGRNRIFTQEMV
>W8TKF1|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium acidaminophilum DSM 3953|TrEMBL
MLSVVVVSISYYSKYNSLIDEFENTAMSKEFLLREHIRMSSNFIKSMMIHGNTFFEHGSS
SDSEFYGLLKYDPKSDSFSMDAAEGTPQEKAVGNITGLGEIPESGKVRDELNLALQYNKF
FGSHYEKFPEVAWLYYTSENNFVNMYPWISSKDFTFLEKLKTVEFYKIANPLHNPFRRIV
WSPAYIDEAGKGTMITLSAPIYDKDNFKGVVSLDLTTAWLAKIIASDYEGYLIEDTNSIL
SVSHSRISNVSDSELDALMKIPAKDFEKLKKLKLNEVQILDGYYIYLASFSEAPWKLFYI
VPMWLVAGKAAASALPILLISVFLIISMNQIEKRKKSEELLKREKELLETTFFSIAEGII
VADKAGRITLMNAVAEKYTGWTKEEALGRDFHEVYNNINIETRERRYNPVAHVLETGKNI
RSDRYISLISRDGSESYILGSAAGIISDAGELSGVVVSFRDITKEYEQEREIAEFLNINL
DMLCVVDTDGKFHKVNKRFEEILGYNTEELEGRSILSLVHKDDTMFMLNVYRELLENKTV
SAFTARCRCKDGSERYIEWHAQIGSGKYIYSSARDVTEKRVLEERLRMSATKDELTSLYN
RHFFESIIAQQTGMADITGEAISIALIDLDQFKQVNDTWGHPAGDELLKSTAQTIERTLR
KSDILARFGGEEFIVLMPKTSIEGAVAASEKIRSAIEIHMHPTMGKQTASIGVAERAESE
AFSSWYARVDEALYRAKHGGRNCVVVAREPDREYHS
>A0A7W7KPM6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas nitritireducens|TrEMBL
MNPVSMNPKQSNDPVKTPGDSAVMVLLVDDQPMIGEAVRRALADDPSIDFHFCSDPHQAI
ALAIQIKPTVILQDLVMPGADGLSLVREYRAHPATRDLPIIVLSTKEDPAVKSAAFGAGA
NDYLVKLPDAIELIARVRYHSRSYLALLQRDEAYRALRESQQQLLETNLVLQRLMNSDGL
TGLSNRRHFDEYLEMEWRRGVREQTQLSILLIDVDHFKAYNDTFGHVQGDEALRQVAAAI
RGNCSRPSDLPARYGGEEFVMVLPNTSPGGARLLAEKLRRSVQELNISHELPAPGAPLTV
SVGVATLIPQNGQACRQLIELADQALYNAKHGGRNQVAIAG
>A0A8E6MJ81|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAEETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRVERSLN
>A0A162SY70|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MNLVLRIDNNIVAIIVSIIFLKNISNSLDKKEIKNKAFVAIFILNTIELITETLTCIINR
QPYEWLIPITNVLHILLFILGPLITYGWYVFANLWVNKSIEYRWKKDIFLLIPIIINTFI
VIPSPFLKLIFYINEYNVYERGPLFFIPVLISYFYLCCGFIMVYANKNKLNRIEFLPLFL
FGVFPALGGLVQSMFYGLLLMWSSIAFSLIILYLYIQQQMMHMDYLTGAWTREKFYNYLN
NRIEQKKHKNFSIVFVDLNDFKEINDTFGHNEGDRALINFVSIIKSVLRNEESITRYGGD
EFVLFLDVDSQQEVEVIIKKISDAIADYNKRSNVLCKLDFSCGYELYNFDKHMTADEYIN
HVDKLMYRDKNKKKKTTDFL
>A0A6S6WLY1|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MPIAHLKLIITALAVIIFNTTFAAEPKAPPLSERAMRVWTTNDGLAHNSVNHIMQDSNGY
LWIATWQGPTRFNGRSFELFSEATGVPDPGSLFVGENPYTQAIISTGPRGGVTHFRDSET
GGHWQPQPRVYDRVDYALFQSSQCTWYATVNTGVVRECDGQRETYTETDGLPSAETFHIA
TDQQSRIWVGTDQGAAYFDPDLNTFKTLPELPRGASFGIVAAARDTIYISIDRSIFVVNG
ETLEVKQWPITYPSTVTELYQAPDKTVWVGTHEHGLTKLSTDALQMVSVENGLPNNHILS
IFVDREETLWVGTHRGLVQFRKAQFHSHRAEDGLGFDYIRALAETADGSILIGGLGGVKQ
LKDEQVLPLNTDSKVVNESILSFALDSDQRLYIGTFTNGLYVLERGKQIAHYQELNGFPG
DNIRDLLITREGFLYAATSLGVLQSKINHDGTLESPRYFGTKDGLPDEIIYSIHQTREGD
ILIGSMRGLSRLKDNNITQIDVSSVSNAEFVFGLHEDTSHIYAATDRGLLVFTKKTNSWQ
VFDADNGFPTIKFFDVVRDHEANLWLGSGRGLLFVEAENFERALHDDDPTTHIPNTFYQS
HHGLASAQINTGGPAMLVAKNGELWVATSRGAGHYIPSQSKTILQSPPSPVIERVKVDGK
AIFQDSYLAADSSRVEFQFAGLGFQYPESIQYRLQLAGYDNDWVYPSNSQLTVSYTELPP
GAFIFQVQAAYPNGQWSDAATFTLHKLPTLWQRPLVWLALILGGLLLVGVGLRLRVYTIT
RSKERLQQLVREQTKSLEQLANQDSLTKLANRRAFDELLSQKVLQYGSQQPLALILMDLD
HFKEVNDRYLHTTGDKVLQRVALLLKDSARGSDMIARWGGEEFAILVTGADAANVETICE
RIRTTIMHANLQDLARNLSVTGSFGAAICVPGESAANLIRRADKAMYRAKHGGRNRVEVA
AGDE
>A0A1Z5I1A9|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MFKKLLITLLLILSVLLTIFMVPTSYAAIKNLSLDHLSVDDGLSQGSIHAIIQDKTGFIW
LATENGVNIYDGNKVRQLPGPNNSFEDVAIYTLLEDKNGLIWLNVDGRKLYSYNPKTNIY
RHIPIKSSSNSNYYIADLLNSNDNKIWLLTSKTLGFYNQVTNEYQQVIDLATELAGDLAL
FKMSLHDGVMYIGSKIGIFAYNIEKNHWKKLPQIPADITAQSNTEELNKIYTVHADINQT
LYLGSNDGFFAINVTDIKAYITGESSLPNYQRLIENMAAWQTLSDGNTLYIAADKGLYSI
NTVDNSSEFLFGFSDYFDNISDDNIPTLIKDNQGVFWLGSRAMGAYQWNPRRELVKNYGY
KKNNAASLSYNEVWHTLPDDLNDDFLWVATSNGLNLIDLAKQRVTRYLVNNDSKSIYTKS
HIYSLLALTAEQLLISTAKGVYLFDKKQGIELALPFNNEINQLLAVEQYDILKEDEFIWL
VNEKGLFKINLSTNEIDTLSEISEQFPPEKLLSLLGSLPDSDWFLLTSNDGLWGFNANTR
EFVQLYKLSGILTGEYTSIDNWAIDKNQILWLSFSGKGLVGLTLPDFKEQYFYHKGNSII
GNNIYGVMADEAGDIWFSSHNGLFMLDSNSQNISHFTRKDGLGATEFNGRAYAKLPNGRF
VYGSMEGISIFEPLKLKKVHHSENFNVKVTAVALLSRKLALPLTIEDNAVINLHYDDVGI
RIDFSTFSYGNEKNISYKYHVTGINNIDYPATREGHITFPSLASGKHTLSIQAKSPYSGE
YSTPVHINFNVSFAPWRSPLALAFYFMVFLLMTLTWYRYRKGQQQLLLDAHEQVKYRENR
LQLALTGSNSEVWDWQADENLMFGKRIVLDLGYKEEALFYSFSKHIALIHPEDHDDFLRS
WQLFISSASLEDNFSCTYRLKTADGQWLWYKDLGKTVAVDANNNPIRVTGSYTNITKSRA
NEERAQYYGDAFQQTQDWVFIIDEKISKVTANKSMRVVFDWPEEEFDFNAKLLGISQKRR
SFYHKLMLSLNEGEHWRGEELIETPNKGEYHVIINVTVGRNSVSNALHYLFVLTDISAQK
SAENELRLLANYDHLTGLPNRTLLLERIKHAIDFSHRKTKSLALFFIDLDRFKQVNDSLG
HDKGDLLLQEITKRLEGVLRIDDTVARIGGDEFVVLLESFANNNQLGSIAEKIIGVIGNP
VDLDKNIVSVGASIGIALYPNDGHNSDELLRHADVAMYHAKQAGKNNFKFYTAQMNIDAM
ERLSKESALKLAVKNKEFINHYQPIIDAHTGKAVGVEMLMRWQTPTGLVPPNDFIPLSEE
LNLIITMTESALQQACKHLKEWHAIRADFYVSINLSVQHFVEADIVSYIRELLADYQLPA
KSLRVEITESTLILQPENAITTMRKLSELGVILALDDFGTGFSSLSYLKQLPLDIIKIDR
SFVAGIGINEADEAIVDTTLVLAKRLNMYCIAEGVETVEQLHYLVAKQCHYIQGYLYSKP
IPPEKIMQNLLLNKTEIISTTRGF
>A0A0P1GYS5|diguanylate cyclase|EC 2.7.7.65|Phaeobacter sp. CECT 5382|TrEMBL
MMTSADLLAMADQLCPMYALVDGNGRLRGVGPTLKKLRPDFEWEGRRFFRVFDLLRPRWV
RSMDDLLQTAGSKLHLQFRDSPHTSLKGVLVPLPDGEGALINLSFGISVLEAVRDYDLTS
ADFSPTDLTIEMLYLVEAKSAAMEASRQLNLRLQGAMIAAEEQAFTDTLTGLKNRRAMDH
ILGRLIGAGADFALMHVDLDFFKEVNDTLGHAAGDAVLQNVAKVMVECTRQTDTVARVGG
DEFVMLFEGVREPKILETLATRLITQLEEPVPYGGRLCKVSASAGTTLSVWNTVPFEAAE
ILHQADVALYAAKRAGRSRHCFYEQGMEKDEQLATP
>A0A011NX82|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MLKHDHFPQMHSSRQASRRLHRRPALPGDLQTGHAHAASAVFEGGSQHRRMRRDRIMATQ
ATMLELLAAEARIADLERALSRAEAAALTDTLTGALNRRGFDQAHEREVARSRRNGSPLA
LALIDLDDFKRLNDTLGHHAGDEALIHLVRILRSALRPSDVLGRFGGEEFVVMLPDTGLD
EALSALTRFQRQLAGCRVAGSGVTLTFSAGVVVQASGESLTESIVRADAATYAAKRAGKN
RVLAG
>A0A8F8CRJ0|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MNKESTSTSRPTFKRTLRRISMISVVITMTLIWLLLSIASVVTLKQYAQKNLELTSATMS
RSLEASLVFNDAAAATETLAMLGKQGQFAVAEVLDAQGKRFAHWSWNPNDNPDALGTLVS
RRLFPTPAVQPVLHNGHAIGEVRITARDSLISHFIWMSFAVLTGCILFAAFVALSITQSL
HNGIVNALQNITDVVHDVKSNRNFSRRVEEERIEEFHRFGQDFNSLLDEMEEWQLKLQAR
NAQLMRTAMHDPLTGLANRAAFRNSIAALMKDSSAQTNSALLFLDGDDFKLINDTWGHAA
GDCVLIEVAYRMVEFGAKRHQSYRLGGDEFAMILYGVHSATDVQQLCAALSQQFLRPYDL
HNGNTANMSLSIGFALTWENTSVEALLEQADRNMYLVKNQRTKIIS
>A0A0L0W617|diguanylate cyclase|EC 2.7.7.65|Gottschalkia purinilytica|TrEMBL
MENKSKFARLLYKSKISFIEKYNLETQDMLDILLNYRITLDNKNHEDLKNFFYAIKKIGS
MFEFERLSQVGGMYEEYLNTTKNITDDSHKVFSNIIKGIGIVKEELRSLRMELIKEENIL
ISDSNYYIDNEKTEENKRKKILILDDDVLTLNIIKDAFEMRGHSIITTSKSYDAIKIITE
LDIDLIISDIVLPELDGFKILELLKRKNMHVPVIFLTAKQVIQDKIEALSKGVDDYITKP
FNLEEVIARVERALERNDNYKARINRDTFTGAYNKTYFEKKIKEYQNNIKTDGIKLSVAF
VDIDKFKEINDNYGHLVGDFILKELISELKEHLEDKDLIFRFGGDEFIILFFNKDEEAAY
SIMESFRNSIINKKFRYNELKPHINISISTGITYVSEIDETSMIIERADKCLYRSKNSGR
NSTICYSKVKNKLN
>W5SMG8|diguanylate cyclase|EC 2.7.7.65|Borrelia anserina BA2|TrEMBL
MKLPKLLSDYHIVHSINTAILTVALGNEMNLNNHKTVELCTIALLHKIGFLFIPLKISAK
KEKLSNEEFEIIKKYPVLGHQILSTTNFSQSICSAILTHKENLDGSGYPNQLKSENINIE
ANIIGAASSYSAILLDRIYKGALNSGASLIELIQDADKKFDKRVLKLIIKVLSQCPIDFI
VELNDNSIAKIIKINETNINTPYIKYIIKDGKIVFPSSEEQNYIKSIPKTETGIKKILRQ
DEIEFILKKYELKEM
>A0A7W5NH72|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. WP4_3_2|TrEMBL
MQRSVKGTAAHTRPDRFSGIVMKRPRLVVTLCFIGAMLLLIAVGLRQLYNMTRNDLHSRQ
RDLEVRAVGVDALIEAERRRLMFLRNFAEHQLSAHEQPSPAEQTAVMKALAASTQPVWHI
AGALDGPNVYGTNAAGLAGLEGFQRDSATLPGDIALARAISPLVQISQHADAVQSTVAFI
SSNGLFVIAPENQGRTVPELLRRFSTMNYYRGQLPASNPARDVLWTPVYTGLQKGESIST
LSAPIYAGNHFRGAVVMDITQSRLLSLQLSSGQTDDDDENNVIEFGLLNSNGHVVYFRNG
ALTEQPPAGFNAALLRIAQTSADRWMQKGSGYVEHRGTYLLYQRVGQTHWMLLAPTDNTE
LTLAAARRVFNSPVIAAWVVLILLLMGTLRIVTNIFSHYVEASERLEMLARSDPLTGLAN
RRRFKEAFAQALERAERAERADHNSNDEGTQATPARMAVLMLDIDFFKRVNDRYGHAAGD
RVLSIFAHLLHANLRSVDLPARVGGEEFAALLPDADLASAAAVAERVRSAVEAHARDSRA
SAGSADAIAFTVSIGVAASPEDGAADYEALMQVADRRLYLAKESGRNRVVHADPQKH
>A0A259UH90|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MKIQDIGGLLFKDRSEVRLTGIRRLWKRQAGRQRKQLHTLAQTYANFESTIAQITNMIKD
KGKLTDLLDQLINEAGMTFGSEHVFLSLLEGQPQVFWVVAYKGSYELRETTLQKLMGASY
AAGQMVYVTSRENLDEHLPRTLLGMPIMIDGKLAGVFEVFVESGEVLTKQQLKLAEIYAA
QAGVAVKMARLNDTLTRKSEEIVLLHEVGQVVAKQPSPSILLEQVGKTLSDFFKADACAA
FVVQRHSVPPVVRAAHVQNLSPADVARLESLLTNGKRSELWQDTNRVLVTLPLAVEKTVQ
VMPLFFRQILQGAIVFCWDYVRETSSDFPIEATLATIANQTAMGLDREHLYGSIKKFGLT
DTLTEIANRRFFDFVLKKELSRVRRYGQPLSLVMVDIDFFKMINDRWGHQTGDIILKEMG
SLLKKQFRATDLPARYGGEEFAVILPETDAATAYALAEIIRAQTEKRVFAPSIDKISVTI
SVGVATVEFSEYLDKLTEADLIFAADQALYRAKNFGRNRVEVSELEK
>A0A8J7SCE8|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MFEDSGRPGPLQLLMMLVQQSGMGALPLSILAPDSFLPFIRQVEQLLLAEKVNPVIVYWR
RHGAGDLLPSGKDFGMLLRESTYVACFSDERIEGPDEWSIIVESPQLSMVVYGQQAVEST
ESHKYQCAGSMDPAIVREAFNRLLPVWQSLALADSNRIEDARISLGPGGSEPRYVQQLRS
LWPVVKGSIQQAVIVDGSTMHDQESSGETVYQLTSPGATVSQAMQTVTGANKIQPIAMDF
GAPDTRTTGGGKAAIGIEPPLGAQSLVIGGPEQPVVEAKAPGNKGNGNSPRRSQNAMASM
PSSAVYGGTLEPDLLAGAESSLMPSKGKKPPPAARTGSGMRAMKPTLSDGESPGYSGKSL
IPPAAQSIISDIIGQLRHSSDLSSILQYAIETLTTILGADRGIIWKIVGDKLAVTNEYSI
GGNTCFVDNQLNPQESTSIVMEFLSRFPDESGAGVISIPDTAQDTDLHKMSRTLSSLLEL
GDVRGRLMVQLRSRGVFSGFLELQQCGTPREWSTEDAVVLQKVAEMLSVVVQQSFDQSKI
EMDAQEMKLINEIASLFRDSKGETGRVSLVKSVMLVADHMGFINSQIYLYNPDVNKLEPR
IRESEVSAVDLTDKDNPFVSVFDSGRSKFVNMEYSRKGDPFFGHDMALVLPLVSEGSRMG
VIGLWQRQPKRPQFRPEDRELGLTIAGHLSNVIRADLAVQQIRADQLRESLINKVSLEIK
RSLKEPDQIMDTLVKSVQEYFNLDLCVVSLYDNREGELIEAKSVKCKFAGDESEFAQPLP
IVQVDQDGMSVVSELPEPPLAQKLTDIIVADALDYFKNGESITLTTEELKEVLGEEHFVD
TWQRRVVTGVPLGQGASFKGVLLLVAKDTGKPLPEKDMRMVIDLADRVGVVISHAELFAQ
VERQAVTDPMTGLFNRRYFEEQLSKEIDRFQRFGHPFSFIIVDLDFLKKINDSLGHHVGD
AAIIHIGNVVKRSVREIDTVGRFGGEEFVILLPETDLKWARMVAERICAAIREKAVEGCG
VVTGSVGVATFPNDAQDKTKLFELADQALFLAKHRGRNQVCTVAEDLLPSLADGGEEKLK
NAMKQDIRMGPAVGAESTSEGATLQIAENFDVQIVKEKGLLGLIAQLIRQVEEHSAYTPE
RSSRAYAYASRVAQSLHLAKDHSEVVSLAAVMCNLGKMAVSEEILKKPDPLSQEDLVYIN
QVPHAGAKFLEPAKILAKISPIVEAYQEHWDGSGYPNGIKGDVIPIEARIVSLVDAYTAM
TSDRPYRPALSKAEAVRLLQEGAGKEWDPRIVKIFLAILNKEKEEAKKEDKASS
>G2DBK9|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Riftia pachyptila|TrEMBL
MDVDKDLKKAYEELLKKTEQESDRRLEAESLLTRTIVRLCLACSGLDPNLDPYLKSIRES
LRNGVNPDLLKELNELSDTLIRLGSPDEAPPAVVWHKLTSRLRLSEADASEAEKIFGQLQ
ADPQAAGEQELDRLALLLSHAIGGDGKQNSFFDRLIKSKRSSESSPGELPNHLLRELLAA
GSWPGHWSTEISRFQARLNDDSAEDEWISVLRELLDLTSTSYSDAQVEIHEAEEFLANLT
RRLHDLETHFREAHAIREEVISSGRNLNVEVNAQVSGLQASIAKATDLGYLKRELESHLS
GIQQTIDTFLEEEEQRFSSSEERERMLRERMRELEQESEDLHFRMVEAHHLALLDTVTEL
PNRLAYEERLAQEAARFNRFDAPLALMVWDVDDFKLINDRFGHQAGDKTLHIIAQNLKKR
LRETDFIARYGGEEFVSLLCGSDEEQALGVAEEMRLAVEKSGFHSGSRSVTVTISCGISG
FIKGDSPEAVFARADKALYEAKRAGKNRCVVADSGFGT
>A0A8G0UXZ6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MAVATAMVVTLIIVLRALYSQYYAYHTLKELLQNHQDSQVRMVAEQLDGKFEIRASMLRH
MAQQFAPMLGSRPAELRRMAAQMPDLPDTFNAVFMAAPSGEMIFSTAVPEGVRMSLSDRD
YFRAIVRGAPFAVSDLLQGKLTRSPGVVLAVPLRGPGGELRAVLGGVINLSLDNFLRELA
RSPVGVTGSYCLVSAGPRPRYAMHRDPAKLLTPARAIGETCGADQPESFWEPIRPRRPIV
GRYLLESNGWELVAVLPANEAYAPLIEARRRMFAIVGLSLLVAGALMWLAMWRLLAPLHR
LHRAVRGITANPAAIKELPVGREDEIGELASTFAEVMHQLSEREAALKAAKDHAAESEKR
IEAIANHVPDFVSFIDMNERFVFVNQAYARHFGLPAQQIIGLTLRELWGTQAYLASRPYL
EQALAGKVVRFTRESPDGSECMQFTCQPAWNDTHDAIHGMHLFARNVTSERQKLRSLEAQ
TVSDHLTGLLNRKGFDRRFAEALARADDSGQAAALLLVDLDDFKAVNDGYGHSIGDRLLV
AFAQRLTRSVRKNDAVARIGGDEFAVILENVGDVRAVERIASTIVQTALAPVIIDGHEHA
ATVSVGSAIHRPGQGMSVSELFMRADMALYEAKRHGKARYAAPLEDSTA
>A0A8J8AK78|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MPDKSDKKSKDKEAHHDPKSYDVDEGWAFNKQDSFAKKIGETRSDMKKFAASKNRVTAER
ERKPLTEEEMADFEKASMYCPLTGILNAKSFFKKLDYELRRAKRYKRPLSLMMLQVDNMD
HYKRQYGAMVEDEVVKSVSKLLQTCIR
>A0A174MIX5|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNTFVAKKASQAVRLLMMALTAVLIFFFINVMLLVSDIQGTARVVNYAGLVRGTTQRIVK
LEDAGQPQDDLLKAVDSYINGLRYGSDDLNLVRLDDDEYQAKMTELASYFDKLRTEIARV
REVGYENTDIIAMSEEFFGICDDATRLAEDYSQEKATALNRLEGLVIIDIVGLVATFAVE
LARAVRTAALNRELQNKVYLDEATGLPNKNKCEEILGQGHPVSAEAPVALCVFDLNNLHT
VNNSFGHEKGDEYIRSFAQQLGCVASETCFVGRDGGDEFIAVLWDADRAAVESCLARIRA
NVSEYSEAHPDMPISYAVGYALSSDFDEPPTMRELFSQADKNMYIDKNRIKTAEAAGPQR
EDR
>A0A174DAH7|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MGNRNGFDRHVEQLWHKGDPFTCAYIDIDHLKHCNDRFGHAEGNRYILGICRTLSETMEH
DEMLFRIGGDEFVLISLSANETELEQRLEQVRAGLIEASSGGKAPMIGSFSFGCSRVDPL
AGDTRRQMTMDADRKMYRYKLMHRVQQPKDDDAPQRPIVDQLPCNDRVFQAISMSSETRY
PFILNLDTGESQWSVNAVRDFDLPSQHPFNSLGMWLARVHPEDRDNVRAELDMVINGTWH
FHYMQYRVMDATGKYVLCDCTGYRLDGTDTEPSMYVGIIINRSLADTTDSVTGLGDIHAL
VNAIGEMRRVAREAGFIAIKVDGIAEVNARFGFDAGDRVLAESAACLMDCSRGKGRLFRS
TGPTFVALFDELGPEAIDEIANDIERFLGSPVLIGSLEYQPPIRVATLHLDGVDRQPVSI
LNELKALLGKAVQVPGTKLD
>V0Y4W2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 908525|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVALLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A1C5KKM6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKKKLAFLAVAIIAVALLLETGILKYVNDRNTYRMAKVLLDRVVTVLNKNDESEDELIQ
SLKDDYIVRAKAVSYIIDAKPEVEHDVEELQKIADLMAVDEIHLFDENGYIYSGSVPKYF
GYNFDSGEQMAYFKPMLTDKSLTMCQDVTPNTSEGKEMMYAITWNEDGTRLVQVGISPKR
LLEETKQNEISTVVASMPFYKGIEIFVADAKTEIIKGATDSGWIGKTLETLGITSAKTKG
EKTGLFYAKFDGNLCRYSLCQDDNYIVVVTVENTFYLQSTVFAILIVGVYLILASCCMIY
LLSRVMKEKYEKEKLIYTSTTDELTRCLNRHAYEEDLNRLDPAEEWIYISMDLNGLKQAN
DSLGHAAGDELLRAAADQMKESFSPYGKVYRIGGDEFAVILTRKVQDFPALLKDFDHRVF
QWHGELTGSMAISYGYVFSSEKKWSSIYEITKAADQRMYESKARYYLENGLNRRK
>A0A1C6KX27|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEEKKRYNLGVLIGGVHTYFPKEHIKGISEAAAELDVNVCFFLGTRTKDFFEDVLGSKQK
NSYDYQFNTIHDYSLIGGLDGLIINYGTLGIQLREDDPNEFARKYNGITTVFLTEIVDVP
NCHSLICDNKGGIAMVISHLVEEHHLSRILFVAGPEHNTDAIERKEAYLETMKKYGLPVT
PGMIAQGDYSEFVDKQVERLLDSNPDAQAIVFANDEMAFAGYRVCEKRGLVVGKDIMITG
FDDCERASGMEPPLTTVQQDGELMGKMAVYDLVNRLDGKDPGKEAVSRRVPVSFVKRESC
GCVSEDASRKETPVGLGAQVHRLNKTIAGMKLELISFQRKSWFIPVLARDLNDCMDDEQA
FLKEIMEKMRELHTRCTHLFLLDEPIVYDGKRKWTCPYNLHLAASYENGRIVTKAAYERP
LVMKENGICDLMEDEERHQFMVFLLFSGEKQYGLLACDIDQEDFPFFYVISLQIGLSLHY
LEISKAEAARRLEMSRDMEEIKEKNRVLGIISEYDELTGLLNLRGFMEHTKRVCQAGNGQ
RAYMIYGDLDHLKEINDTWGHPAGNFALRSVAEILKGCLRSNDILGRVGGDEYIIMLECE
EADFGEKFRERVKMACKLFNEKSGKPFLVEISLGIAEFRPNISTDIQQVISLADQQLYEA
KKHRKKSVSRANNEGA
>A0A1C6JQM5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKIALITDGWGRYVTYTWIQGYRNYMAAHQSDMDLYIFQSFGNFSMDEKHNAGEYNIAR
LPDFSEFDGILLDLATVSQPDLIAEIIERAKLSNIPAISLLEQIPGLYHSGIDNYEAISR
IVEHLITEHGCRTLNFIGGPEFNRENQLRFKAYRDALLRHGIPFEEQRVIHHNYEIETGI
QAFSTFKEKNLLPDAFVCVNDNTAVGVCLAAKEAGYSIPGDFLVTGFDNEDKASYYEPRI
TTVGFSKADIMENALLMLEKIWNGNAEETYIYAPFTYVFQESCGCVSQNPPDREEYVIKR
IVAEARQSDMQNWMMDLNRVLLDCSGYTELAGRMQNWLTKHGCGNIYLFLNPDIFMSENM
DALPELPEDTYQTEGYPEEMSLVYPPLDGTNRLQLNLKEILSLPQAEATRGQNIYQFCPL
HFREREIGFLIITNCDYLLEHQFLFETLNALQTSMEALYARLTLRKMNKQLSQLYIHDSL
TGLYNRMAYEKLAMPLFHQCMQENQPVGIMFVDADHLKYINDTFGHDMGNLAISSIASVL
RQHCPAESVSIRYGGDEFVCVIPDYNKQKIQELAHTLQDSLEVFSANSRMGFPIEASIGW
VIADDPGLTLNDYINLADEKMYSAKKARKAERKI
>A0A1C6JML2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MVKGLCRKFNALLRKEAVHENEPQRILFLLRIILLILGLYFLIIPLVFCIVGPKTEVWTG
YIFAAMSVAAFYATYRLKVHTSVLVCSSLQLAWVIVFVILYGWDCGIQHLMFEMLVLVYF
AVYNSLVYKVSYTVVLFAVRFSLFLYCRVNISVFALTETATVVLQIINTIVTFVLMAVAC
SMFSSNVESAEKKLVLYNEQLKKQAGTDPLTGLWNRRQMIQYITEKRRKEPVMAFTIGMG
DIDFFKRINDHWGHDCGDAVLVWITQHMSRELGEHAKLCRWGGEEFIFFFPDMNGDEVCL
MLNTFRMKLGNDLFDWRGEWIPVTMTFGVEENDFKSNIDTLLKNVDAKLYMGKEQGRDRV
IY
>A0A1C5W7Z0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MVPNYYNIIHMNTNTNNHKTSYSIIRGLFFLIMCSVIFTVLYYSLPRQNREPAISDYIDF
SEGWTTSDGSPVDFSHISGTCTVTKKLPALTHDMALFFFYKSSNVTILIDDRLIYETMQP
ERVFFGKTPGASYVSLPIYREDSGCTLTLVIDNPYGDGSGKINHMYLGRSEDILISRIRD
KAPGFGISFLIAHLGLAFILFYLPLHKKHIIGSEMLYLGLFALNTGIFMLADNRMLQLIL
RNSHIYHTIAELFMMLITIPLFLYLGKMYTEYSPVMVQAACLISVMDFSIRFCLNLTGLK
DFHESLRLTHITFGILIALVIYAIGKGFYQNQRQHLKHNLYHNLGILCLCFGVLLDILLL
WFGSAPETSFFTRIGVLLFLIMEAVQVTLRLMTNYQEGVRMQLLSRLAYRDGLTDLLNRT
SYMEELKRLDASHNFHVLLALYDVNSLKYVNDTYGHQSGDKLICRVADTLSAHLGSLGKC
YRIGGDEFVFLSTVFDSEKEFLKLQRDFEASLGTLKLPDGSEHPITVAMGYSVLTHNMPR
SMDDMVREADAKMYEAKRRMKTEN
>A0A1C5M7U4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSYANHYILSTISQLQPDQQTVFAYDIKMGNIQNLVSSLVSYDREQMMIFDDNGTVIGST
NSDYLGGNLWDSLEDIKASIEETRASIEETGASIAETGASPEETKAGPEQEHIPAAAGSL
SDAQTEKLKEQIQSAEAFLSFRKGIDAGLSNLLDQTSTVLTVKSGNSTYFGYLQPGNGYH
SLTLVPVASMLKSSVQIWLVPLLLMELLLFYILGRISKDRKSRELKAAYIELGQTQRRLE
LALSVAQKAAAIDDLTGMMNFKSFRKNVAEYLNSMEKDESGILIMLDGDRFKAINDNYGH
SVGDEVIKLSAQMIVGRIRTIDLASRLHGDEFAIFVSKTEDYSVAKRIIDDINHTIAAEA
SRRNMPPITLSAGAVTARQGDSYSQLIKAADAALYRAKATHNGGFSYAPPA
>A0A6S7FI28|diguanylate cyclase|EC 2.7.7.65|Achromobacter insolitus|TrEMBL
MEPLGGFLMSSSSIDVPLLPGQRPGASSQACYLSASNEQAWVAVYQSVDAYTRGQVAAVV
GDSLSELVDAFYSTLLADAEAGPRLSHEIVSSRLHAGMTRWLKGLLCVRDQGDIGVLMAT
QKKVGEVHARVHIPIHLVMAGARILKNEIALRLRASDLDGMAASIATQYVCNLFDLAVEQ
MSRAFMRDINRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLP
RLAASEFGLWLQHKGGAMFESAPGLQQITDAVAQLDSVVLPQLMRGEEQGQAAVMPDLVR
ELQELVARIKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSEFSVL
LLDIDHFKAINDQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAAQEAA
LAAAEKLGAEIRRHVFNIPEAGPLHITASIGVATFDGHPDYAYLIDRADKALYQAKQAGR
DRAVAA
>G9A7Q2|diguanylate cyclase|EC 2.7.7.65|Rhizobium fredii (strain HH103)|TrEMBL
MRLRRASGRANHIQKHRDKRLLLVEDSRMFAAALKHGLELTHGINVAHCASLAAVKAEVA
AAGEWAFSLAVLDLNLPDAPNCEALDFILANNVPAIVFTAAFNDSTRGQILNRGVADCIV
KNEPESIERLIAAVDRVLTKGRTTVLLVDSCAASRQDLASILRRGLFAVIEASEAWEALQ
VLDQGEAVDVIITDTGLADLAGLALLGEVQKRQGEDAVPIIGLSEQGDARVAARFIEAGG
ADFIRKPFLEAEFSGRIRHAAMLQKRIQALKLAAASDYLTGIFNRRHFFMTGPRLVDQYL
RRGEGTSIAVLDIDHFKRLNDTYGHEIGDLVLKHVAGRLKALVGDQHLLARLGGEEFGIL
FDGLGVRDAFAFCERLRAELAKSKIVADDEDLAITVSIGLATIEAPEAFENYLHAADQFL
YMAKHAGRNRVISELALLDALAS
>A0A1H6CJP5|diguanylate cyclase|EC 2.7.7.65|Halopseudomonas aestusnigri|TrEMBL
MPRLSAEQLSEEWGLLNQKFSQQSRRFVLEFCIRHAVDLTETFYSEMMADPAASLFLSHD
QVQGRLSLSMRRWLEGLFDSEDEVALARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FVALLQEDCELSDREHLDAARLMSDTVDLAMEVMSHAYATSHDRNSRNEEAYRLFSVTQN
IATEKERQRAALFDWENQLMFDQAVGQSGEHLPRILASEFGLWFRHKGAHAFEGAPEAQQ
ILDGMERIDDVLLPLFDQDPAERIARLRELRETVKAIRFSLDHLFEQNNELEAGRDVLTR
LLNRKFLPVVLTRQVSHARSHGTPFSVLALDIDYFKQINDSYGHEAGDRVLQQLASLLIN
SSRAGDYLFRLGGEEFLMLLVDTGLDGARRVAEKLRRGVEQEVFRLPQDRTLNITLSIGV
ACFNGHPDYQQLMRRADDGLYQAKHSGRNRVVVVE
>A0A3R0XSL4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMFALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTIMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A3R0JQG9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A2X2IFQ7|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGRNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTALCVTVRKLSDIFIHSER
FKCNVFYHFMFEEKSYFLN
>A0A3R0JU90|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLSLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A3R0XBS4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MVSMGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVI
FLFMLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYI
FRQLSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLY
VVDYCPDNHTATWGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLL
LTLDEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFN
SVESLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARL
EGEVFGLLFTELNSAQAKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNI
SLVMTEADKALREAKSEGGNKVIIHHI
>A0A7W9U0Z9|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia bannensis|TrEMBL
MTEKPNDSSAPDAALTEGGPDEASLEGALEAVRTALEQPLPGAADVPMMVLLVDDQAIVA
EAVRRALSSEREIDFHYCSHPEQAVGMAEQVRPTVILQDLVMPGTDGLTLVRAYRANDAT
RDVPIIVLSTKEEPAIKSAAFAAGANDYLVKLPDSIELIARVKYHSRSYVNMLQRDEAYR
ALRRSQQELLRANLELRRLTHSDGLTGLSNRRYLDEFLGAEWRRAQRENTEVSLLMIDVD
YFKPYNDTYGHVAGDNVLRSVATTIRREVSQPRDLVARFGGEEFAVVMPGAGSAFARLMA
EKMRRDVAALQLPHVGSKVSEHLTISVGVATLTPSAGLAETALIEEADAALYRAKREGRN
RVAFSNEVTARS
>A0A5P9Q181|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. YIM 10|TrEMBL
MPGAVRTADRGLCCEKCGEPLGYRAMDRLTGLPGRWEWDHQAGHALQGLAHRPGVVLLVD
LDRFQAINDAHGHLAGDTVLTSVALALRNTVRDGDVLGRFGGHDGDEFLVLLPATRLEQG
LSVARDIRTRIRTIVVTVRSAIGHTVVIEELTSSIGVGVHHPGLGTGLRELVGEAHLALQ
TAKRSGRDRISLPPVA
>A0A517MVT6|diguanylate cyclase|EC 2.7.7.65|Adhaeretor mobilis|TrEMBL
MTPSKSDQVMEATPPAATSASEAHCLFDAKNGQLVAIDELAAAWLGTPDYNLAGATLDGL
LPAEEVQNAYANALLSPGTRSNPCPLELSTHLNMGDLVPILQIDFVQLRGLPAVGAPLGQ
GLSQGHLQIEPDRKFVLATIKIKGPVEKSTHRDALTGLLDRTALDSAQVLKEAQPYAVLF
ADLNDFKLVNDQHGHAAGDVVLQEIARRWQEAIRDDDLLVRYGGDEFVFVLPRLESLTAT
LPIVERLQRALNEPIRVGDLKLSVGVAIGVAIGNGESSSMAELVHKADRAMYANKPGTLN
ASSR
>A0A1V5IQK8|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MKRWTELVLVACAAGVAVAQWFMPATAPGLLGILLFGLVVLTAFSQRRAIDTTLVSLNAA
HREQLEGERRYRALFDACSDVIIVHRFDEEGRPGQIVEVNEAACLVLGYARSQLLSMTAE
DVLAPEARSHARERARALLDSGTLAYETVQMASDLQRMPVEVTARIVEIGGRRLCTSVSH
SIAAHKEVEQYLRNLTDVDELTGLLNRRGFFAKVDEMRRKAKRTGRQVLLTYFDVDGLKR
VNDELGHAEGDRVLVAAADVLRGAFREHDVVARLGGDEFVATALLGRRHDEALDRQAIEV
RLEQAVRAKREELGDAYRFSVSFGSVVANHVELAAIDELLTRADQSMYEVKRGRTTRLAS
RRPPSDAGVSPRPGLVAVDAPPPLEAHDAAGRW
>A0A517MWT6|diguanylate cyclase|EC 2.7.7.65|Adhaeretor mobilis|TrEMBL
MFKFSTDLPTHERLIEALLTATVLAIFALMWFYYVDTPWLLHLYYLPVVLIGFFLGKSRA
RLLAMLSVLTATIIFVPNLSAGASSGIPLATILAFCLWIVTLITTAILVGSMSDRWRVAM
HELRESHKKDVLVDPLTKIANRRAFEFELARRLAEYTRHGVPAALLSFDIDYFKSFNDRY
GHQAGDAVLRDVAQSLVESVRDTDLVARCGGEEFSIILPGADSAHAKEIAERARNLVEAT
RFVYNGLTLRLTVSVGVACITDDDDAEQITSRSDAALYQSKESGRNCSHIHDGIRCRKFG
NGVAKETSESLKSTEVAGVKGELYTDPTTGMPAVKVFLEELRRRTAEAHRYGGKFCVAIV
KINEYLSVDDKDARAQKSLIATVAQLTTSVLREPDLVVRYDKDLLAIMMPATTLERSLIP
LQRLRKKADEYREKQYPSLSYGVTIGVVQLEEEDSAGSLLQRAESAYQHAAESHHEGVGV
STQGTLKVVCGEQLTAST
>A0A530M704|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSISLIFPSINVIEAVIGALLLRKLLPWYNPLQN
LNDWIRVAIGSALMPPLVGGVLVSLLAPGTEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPVALTTQHAGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQALTFQQLTWPEDLHTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHETML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPV
LTVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIQTINEYHFIWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMV
TVYEPQQERDHNTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRASAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCNPDKNLQRGLQKLRQAGCRVIFSQVGRDMNVFT
HLIANMADYLLLDAEVVTNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A8H2NWP7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSQSDTRATVLAQYPEDSREAAALLKQAVPLMVRHNIAPNPVHYALWYTYSKGQEPELNR
HLDRLVNDFDYFPPESATRLFREYIIRDELADARSGQQDAINLVDDMERDVSRSVKGNQS
FQASLGQYLQMLEEPASERLPSILIQLQQSTRLMQGQQEHFLAQLQSAQHEIKSLRDKLE
RAQLAATLDGLTELLNRTTFNRQLEQAMGNVATGVALVMLDIDHFKQFNDQYGHPLGDRV
LQHVARVLRDSLPGEAFAARYGGEEFCVVLKDCPDLAAAGAFAERLRLKVQALRVKARGT
DTVLDTITASFGVAHAQPGDTPESLLTRADDALYQAKRNGRNQVRQQPDVAVGAV
>A0A5E6TW39|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MIRSARRDRRPTLRAVLGRGHLGVALLAVGLAGLCVTLLGVLALRVYANQNLHLIARSIN
YTVEAAVVFDDSAAANESLALIAANEGVADAKVFNNEGELLAHWQRPEDGVLAPLERSLA
SSFLVEPVHMPILHQQQQVGHIEVTGQGRSVLRFLLSGLTGILLCMLLSAWVASHWSRRL
FGDIIRPLRNLASVAHAARRERSFDRRVPETHIAELNELGNDFNALLDELENWQNHLRSE
NATLAHLASHDSLTGLPNRAFFEGRLSRTLRTAERHQEYLALLFIDCDHFKQINDSQGHA
VGDEVLVTVAARVRAQLREHDLVARLGGDEFAVLLTPLQSCEDAQRIAEKIVASMKLPIA
LNDGTSISASLSVGIACYPDDGHDPASLLNAADAAMYQAKRARRGQWHVAHTESSAADFE
KRS
>A0A174UPS3|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKKFLGDKTMDVSLLEEMDFDNVNIDWEFIETILKELPSNIYFKDTQCRYLFCTHYWNHI
VHDDTEAWSIRGKTDMEIRKDKENARKAYEEDKKLLKTGIGCKYVIETCIDGVTEFLEII
KNPVKNKDGRIIGIVGLINIVTDRIKLQKQLEAYAQTDIMTGLFNRRYLEYWEENEIKPQ
YFPISIIAADCDGLKHTNDTYGHHVGDEMIRSAAQLLKDVLADQAVMFRMGGDEFLMILN
NTDEIQVQNIVDRLREKIKQTYVKGIPLSISFGVCTMKDMITDIENAIYIADKRMYREKE
EKSVLKQ
>A0A174CV27|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MMDKNPKAHFVAALLDIDDFKFINDIYGHAYGDKALKSLADSMKTFFSSDALLGRNGGDE
FCILLQNYNCEDAKELLQQFTGLPKAFSYKGKEQSFNISLGYAEYPTFAASRSQLMRCAD
AALYEIKLHGKNGCMAYREGLQSGIRKQLGFAFKDISEHLPGAFIIYRADKDDDELFYAN
HEFLHMTGYKDMDELFRLTNKRFRNLILKDEQKQIESSIWEQIDSGNENDYIHFHLRKAD
GSYLSVLDHGRIVESQQYGRVFYVLFMDWEDMHIHYSDKFSG
>A0A379J3W8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGDTSDLDPLNSELFDVNADLVHAIMELVSDGIWDWNANTGFVYRNPGWYEMLGYDHHSL
ENTVFTWESVIHPDDYPHVMKVFDDYINSRTPHYQAEYRCRKKDGTWLWIEDRGYIIARN
ADGSVSRMVGAHRSIHERKRSLEQLERRNQSLEALVAERTRELSRVNQQLQLQLEENRSL
AERDTLTRIANRYRLEKALLEECARAQRFRLPLAVIAMDVDDFKSINDQHGHAVGDATLL
RVVECLEHCVRQGDLLARWGGDEFMLIMPKSTVETARILAERIRRAVLDLPPVGDFNVTL
SLGVVQRLDGESPADLMARADQALYRSKAAGKDRVSQ
>A0A379I764|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRLRNATTRPTLRSVLGRGHLSVALVAVAMASISLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDRVVATEALALIASTEEVAEARVLDLNGSTLAHWVRPETGVLSRVELELAH
TLLEEPISQPILHQGKKIGAVELSGHGGSLLRFLLSGLAGIIICTALSGWVAIYLARRML
RGITGPLHRLADVAHAARSERAFDRRVPPAQIAELDSLGNDFNALLDELEAWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRSAAKLNERVAVLFLDSDRFKDINDNFGHAA
GDAVLVAVAARVRAQLRESDLVARLGGDEFAILLSPLHKLEDAQRIADKIIASMDQPIPL
PGDTEVLTSLSIGIAVYPDHGVTPGALLNAADAAMYQAKRLSQGGQHTAESEYSAANVQH
RS
>A0A5E6SI13|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKVSDRFNQIPVSVMNRFQGKGLAFAKRIYAPRTVGVSVGFLTVAASLFHLNAAPWLWAL
AFFNALIWPHVAYYLARTSRQPYQAEWRNLLTDSFCGGFWIGAMGFSVLPAITVVAMMAM
HNIAAAGPRLMLRGFVAQAAGIMVSLLVLDPVINLESTPMQMYACLPVLVIYPIFIGWMS
HQVTLKLREHRNILHRLSRTDSLTGLLNHGAWKELLDLEFAKSRSLSQDCVVALFDIDFF
KTINDTYGHLVGDTVLQSISQAMVDNLRKNDVTGRCGGDEFCVILPGANTAQARKVLEKL
RLAIDELTYSLHEDLKVSLSIGVAAYNHGLNDTSAWLHEADKALYLAKSTGRNRVVIADD
IRADCQDMSVQT
>A0A0M6ZWJ1|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MTETSRKAETDFTLFDSEDRVLEHASTIIDGLEETTDLIKTLTTAYKRAVKDQKRMVRLC
DRMQEELIAVKERLEGEVTARAELAEQFRMQAITDGLTQVFNRGHFLELCNHELKARSRT
EAPLSVALLDIDHFKSVNDTYGHAAGDEALRVVARTLENSLRQSDVVCRWGGEEFSLLMP
RTNSENASGLADRLRKTLSEIVIKEGGTSFSLTASFGVATMVGPNPACKATGADAIDLLF
KDADDALYKAKDAGRNKVITAEARLLETAEAVD
>A0A379I8Z7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGDTSDMDPLKSELFDINADLAHAIMELVSDGIWDWNANTGFVYRNPGWYEMLGYDHHSL
ENTVFTWESVIHPDDYPYVMKVFDDYINSRTPHYQAEYRCRKKDGTWLWIEDRGYIIARN
ADGSVWRMVGAHRSIHERKRSLEQLERRNQSLEALVAERTRELSRVNQQLQLQLDENRSL
AERDTLTRIANRYRLEKALLEECERAQRFRLPLAVIAMDVDDFKSINDQHGHAVGDATLL
QVVERLEQCVRQGDLLARWGGDEFMVILPKSTVETAKALAERIRLAVIDLPPVGEFKVTL
SLGVVQRLNDESPANLMARADQALYRSKAAGKDRVSQ
>A0A5E7E6N4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKTGGKGLSLARRLYTSRTLGLLLGLLCVSVSMYSLNPPLWVWALMLSNGLVWPHLAYQ
LARRARVPFHAEHRNLLIDAFFGGFWVAAMHFNPLPTATTISMMAMNNVAIGGARFLLAG
SAAQLLGVGVGLVVFAPAFIPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGVHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFATLGYEQNPA
LKVSLSIGLAAYDPTHPDATRWLSDADQALYEAKASGRNRVICNSDSLPKQPLLDSV
>A0A5E6QC84|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MMEKKSGKGLSFVKRIYLPRIIGLGIGMLSVMAGIASLPVPPWVWGLLLFNGLAWPHLAY
QLALRANVPYHAEYRNLQLDSLMGGFWTATLQFNPLPSVTILAMMAMNNFAAGGQRLFFK
GLLIQGLGMLLSIALLGPGLQLHASTLQVYACLPMLTLYPMAVGWVCYRLAMKLSEHKRR
LSALSRTDSLTGLLNHGSWKDLLQLKFQICQQQRREAVIAIIDIDHFKAINDTYGHVVGD
CVLHLLSNELKRSLREDDLAGRYGGDEFCVILPDTRLEHARQTMERLRERVGSYRNPQLP
ELRISLSIGLASCNEALPDPEAWLNEADKALYCAKKAGRNQVNFADPDLTALKLAYPE
>A0A0F3N137|diguanylate cyclase|EC 2.7.7.65|Rickettsia amblyommatis str. Ac/Pa|TrEMBL
MTTILVVDDIEPNIKLLTAKLLKEYYTVLTANSGKEALAILKKGKIDIILLDVMMPEMDG
FEVCKTIKTDPETTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSR
MKSLIDELKLRNSTNALLGVTNIEMHDTFADKKILLINDDVVQAKNIKQMLLKITQNVKV
ISNSDELDIINEYTPDLVIISSTLENDDPLRISVILRGKTEISGVVIILQIDEDGMPLVV
KGIELGINDYFVYPIEESELLARIRTQLKRKQYQDNLRNDLEQSVNLAAKDGLTGLFNRR
YFDIHLKQMIEKANKESIKLYLLMCDIDNFKHVNDTYGHQAGDKVLTIVSRILKNTLRVT
DLIARFGGEEFTILLTDIDISKAIETAERVRVKIEYMDFHIEDQIEPLKQTISIGVTKYK
KEESIESFIERADKAMYEAKTTGKNKVVKL
>A0A8B4I9K6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MFIDLDRFKSINDTLGHACGDKLLVAVAERLSQSVRRSDVVCRLSGDEFAILVSGMDQAA
QVEALAEKLVAAINQPFVIEGHCINTYISVGISLFSAGGARIEQFLAQADSAMYQAKKSG
GNTCHFSLLHASAG
>A0A1C5XSP9|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MEDKNSELLFEYLRSILYDKKIQPLDVEQLDEPFRKLGRGLQYFAKTFTETKQYAAALSR
GNLSVQPPPRENFLCENLKNIHANLNHLTWQAKQVAKGDYSQTVSYLGEFSEAFNTMTQQ
LKERELKLKQEAEREKIHAGMVETYNQLLVEMIDRSEEEIFVTSADGRRILYCKKRNDRS
IDRNEVYQMCIRFAQKHRSEESRDSFEWIWEAEDSRHHFYRIITGYMQWQGEQAFLYIIR
DVTKEKLREERLRMEANRDGLTQIGNRHYFLEKAGDMLKEESSLTFCYCDLDHLKYINDQ
YGHTEGDWYITFFVETIQKHIRKEDVFARIGGDEFCVILYNCPYEMAERKIRKIQKEFSS
GQTKEYSKSFSCGIVEVEGGNEELQVRDIIKQADHEMYLQKKEHKKKYRKELSVISISED
>A0A8B6X0T5|diguanylate cyclase|EC 2.7.7.65|Derxia gummosa DSM 723|TrEMBL
MTILPKNRLSLRLVLIVPYLALVLGLAGTIGLLSYLAGSNAVSTLSDHVLIETASRISQA
VDRHIVGSGATLEAAFPDGMPAPVTIESDLANLRTRFWIATSLHIDPNNYVYYGNRAGQN
IGLFRHSLGEGELRIKLKAEDTRTVYRFSGINGDLNFDRRENRLFDPRQRPWFKAGENTS
SDTWTAVYIDFGTQELVATRARRVLNTAGQFEGVVATDMSLRALNDFVRRLKVSPQGLAF
IVEPNGDLIASSVSPNVRAVPGGASARINAMDSGSPLLTATWTEIRRQLAGGGEPGLPQT
LSFDDDHGRHVHVAFDRIRDRAGLEWITVVAMPREDFMGGVMRNVGRTVVAALLAGLLAV
LIGLRVINWVTGDIKRLSVAARQLGEGRFDLPVNVARRDEIGELARSFTAMRDQLGTDSL
TGLANRDAFLRRVDRDIGAARAGAGAPFAVLFLDLDGFKGVNDSHGHFAGDQVLKALSAR
LSARMRDVDLIARFAGDEFVVLGSGIESDGDLAAFRGRIVAAFAEPINITGGDGRSLRVN
VGCSIGAARYPGDADDANTLVKTADRNMYAAKLGLADQSRNPAA
>A0A8B6X8X2|diguanylate cyclase|EC 2.7.7.65|Derxia gummosa DSM 723|TrEMBL
MNSIASRRDRLLRLAATPALVGLVATLLASALVLTVSHVVRDRLVVERRAEAQAALFRVR
DQLDRQLHNVLAIPETLGAVVAVRGGIEETEFALVAQRLVASSPYIRNVALAPDNVIRQV
YPLAGNETALGLSYLDKPEQRDAVLRAIQTRRTVVAGPLRLVQGGLGLVSRTPVFRAGGE
AAAHAYWGVVSLAINADVLFSEVVARADTRYYDVALRGTDGTGASSKAFAGDDEVFGDEP
VLVDYPLPGGGSWEIAARPTGGWASRTALPWQLVALAQGMALLVGVLTWRLAVGHRRVVA
LATIDRVTGLPNRRLFDDRLAQAVALARRRGHHGALLLIDLDGFKEVNDRLGHRAGDDLL
RQVGRRLSLVGRPGDTVARFGGDEFALVLPEVDGPMAVAEAARAIIDAMAEPLPAGDEST
AAVGASVGVALFPVGSESIAALFDRADRALYRAKAEGGMRSVLASDT
>A0A8H9EED0|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLTPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSNVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRYLQIFNTLKA
NMVDYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A829J770|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KOEGE 73|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKISQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2I8QPP9|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium ENNIH2|TrEMBL
MGQEKVVKSPPRLAFVKTWFVPSRVVNLCFVIVLVCSTVLTWREVIVMKGAYVVSQRNAL
DNVTNVLDRQMQVGIDRLLFFRNGMQSAVQTPLAFDVLRNIQAEFEKERILPYWQIGLDN
RRTLPLYGVSDYFVDQSALLSRDNPLLHNELTAAMELGYLFRFSSSASMFPRRALYVSRA
GFFISTLPVGNNNEIVQQYYQHLTSPWFSGQSERENKLRGVRWFSDEAHTPNIADSLVTA
SVPLDFQNYWYGVLSMSFPVSSMKALLTEARQSQDKGEYQLYDAQFTLLTTTADAGTTSQ
QFSSDEHAQLQREMARDTAGGLRLGTRFVSWVKLKHFEGSVLRIQTLHEGLRGDFGSISI
ALALLWLLFTTMLLLSWGVIRRMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERAQVLT
TECAAQNLPLSVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEE
FCVLLPGATLADATAIAEKIRQRISSKEIFVQKSKTIRVTASLGVSSALESGNYDFEYLQ
SVADSRLYHAKNNGRNQVCAEDGVTPLPNT
>A0A1X3JXR2|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii B156|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A2H5XSZ8|diguanylate cyclase|EC 2.7.7.65|bacterium HR19|TrEMBL
MMVKNEKLKSILQFNKYFSLPENISKYRSEFSKHLPLFIDRIKILKKINEKLKDGEKRYQ
IEGDIDFLKRISEKTFDKDLKRHIEHTVNFLENLKRQKNNLSECSCKKKEFQNLHEIEEE
VKENYEPEKLCRYINETLKVVISDLIKGFESQIAKLKKDALTHAWIRICLHDDLKNIVKN
LEVNRKEKNTKNKKLFIAIIDSDKLKQINDRFGHSAGDIVIEKISEIIRKSIRKSGRVYR
YGGDEFVLIIEAKDENEFLKVCEKIREKIGKTKIKLDNGEYVNTTVSIGATRIKSKNIKN
LLKTIDRNLYRAKKMGGNRVIFS
>A0A1R4B5I4|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MTDLFEKSTIHHQELELFSTILDHNTNAIGVTTLEGELIYRNKAFQEYFPYTDETNIQPL
FPITFARINFDKIKTELEAQDDPIHFVETNLQNNAWSHLTVTLTSVGPVQYFIFNIDHML
SPEREGVRVNMQLEKIIDQLPVLVSHIDNNDKFIFANHAYTEFFQCTLDDIIGYAMQDFL
GAEIYDPNKHFISRVKTGETVEFDVSIFKGSDLRMLQVRLIPGESFFGDYYIFAQDVTEL
RTFQKKLEYRAYHDSLTGLTNRTYFLNDLEKKCKVKTNDVGLLFIDVDGLKNANDKYGHD
CGDKLLKDFAKQLKSLLRPSDNLSRLAGDEFTVLLSGLNEPLNDLHDICQRIQERLPSTM
TINNHTIPCSCSIGATYIDPHIDYTVEQWLSIADSAMYRVKHHGKGSYNVEIVSPPNSAN
VEE
>A0A7Y0E113|diguanylate cyclase|EC 2.7.7.65|Pacificispira spongiicola|TrEMBL
MSDHADPSQTESPTLVPGDILTAIDAAIEEQGRWSARWHRSLVCGLPLPDDVKADGSENL
TEFGRWRSRHNDDPLLTQPAFQGLWERYTAMHDAARRIACSVERPDDRIHSEDYDGFLSA
SDRFLSTARRIRDAFRKAVSDLDPLTGLSNRATMTAELTVEYERAVRSGTPCCLALADID
FFKKVNDTYGHAVGDEVLAATAGRLTSHLRPYDMIYRYGGEEFLICLPNADLEIARAVLE
RLRESMAERPIKLEDGRELPVTASFGLAQITKDADLKAVIERADAALYQSKEGGRNRVTA
HGDTQVEA
>A0A7G2JNF6|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MYEPCFPENETERLSVLHSLNILDTNSVEKLDRLTRLAAKYFGVSIALISLIDRERQWFL
SRSGLEARETPRNISFCGHAILQRDALVVPDTAVDPRFFDNPLVTGGPKIGFYAGQPLLS
LDGLPLGTLCIIDGHPQAFSSEMVHDLRDFAAVIEEYLHSIERDIYTESLKSNLQRTEAL
FEQTFAQAAVGMALVSLEGYWLRVNPRICEMLGYSERELLDRTFQDITYREDLHTDLGLL
KQLLANEIDTYSMEKRYIRADGSTIWVQLTVSLNRLPNGEPHHFISVIVDISERKAAEAD
LYALQHELEDRVVTRTRELNFAVNKLNHEIANRALTELQLSSEKERLRAITDNMPALISQ
IDVNERYLFANSAYKSWFGLDESQLNTMTVQAFMGDEAYAVARPMIERALQGETVSFENE
LQTRQGTAIIHTTLVPSETQGFYILSMDITELKRLQRRLEYDVSHDMLTGLTNRRAFLLR
LGATLQACCPQQQMALLFIDLDGFKMLNDSFGHDFGDLILKTFAELLNACAGPHHSVSRL
AGDEFTVILWPLAHPQLQVSAFCESVLVKLAAMERVGNQKVNLSASIGAAITSGGDITAE
ALLTKADDAMYRAKSAGKGTYIIR
>A0A7G2JKV5|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MYTPSVIDTRRSGLSFAKRTYLPRTVGLGVGFICVFSVLYSQQTSPWVWSLLIFHGFIWP
HLAYQWARRSTMPFKAEIRNLLIDSFFGGLWVAMMAFNALPSVVILSMMGMNNIASAGKS
LFLKGLALQVFSALAISALLGFPFQPQSTPLQIYLCLPMIYLYPTLLGLVTYRTAKRLAE
KKQELLRISMRDGLTGLYNRRHWEHLLHHQFDSCRRYQHSATLILMDIDRFKTINDTFGH
ALGDEALAVLAEELLIGLRAVDIVGRYGGDEFGAVLPNTSAEQASIALVRIQERLNDIIF
REAPQLRLNISAGIADYHSDMSGYLDWLKAADNALYRAKNNGRNRLELAIPATKRVN
>A0A136WHX7|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MILHYVSLGIVSAMAMLLLCIIINHNETLNRKMKMFFTLAIIGIIIVTLAEVASYYYAKP
NTDFRLQRIICCEIIFCVSPFITLFITLAFCKLALNVIVIWFLPAIVNLFLTLLSPFFGF
IFYVSANNVYSRGPFYGLFMLSIMLGGVLLIFETVNSDKRYQSKNGHILYLILLFMVIGV
TIQILLPMVHTIWICVALSTSFYYSYFCELSEKYDAQTFLFNRRAYECELERIEDAAHAY
ILLFDIDDFKIINDTYGHQYGDECLYKVACCIKDTFQSLGLCFRIGGDEFCVVSKNIEEK
IIIDAKKDFKKKLLECMEKDKRLPKVSLGCGYYKKGFCQVSEAVRLADEQLYAAKNVKKF
V
>A0A7Y7LD17|diguanylate cyclase|EC 2.7.7.65|Mucilaginibacter sp. SG538B|TrEMBL
MSKKILILDDSEDILEVMKEALEMEHYEVEVLNYTDDICKAALSANADLVILDYILFGIN
GGELCHMLKTNPATAHIPVVMVSAYPRVLESLGSYGSDAFIAKPFNLSDVIDTVNHCFLA
AGDDVAHMV
>A0A395L7A2|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MGLQAQTPVLMALYDQHDRLQFANEAFRAAYFVDAEETPTWADIMRRNHAASRGTVLSTS
DIEGWIASTIHRRGKIPFRAMETDLHDGRWLWMTETVDAKGWMMCVAVDITTVRVEERTL
RQDRDFALRASQVDELTNVPNRRHTMGRLGEFIANCAQNPHMWGCVAIIDIDYFKAINDR
YGHHQGDEVLLDFARQMQEFVRRSDCFGRIGGEEFMLILPDTTISEGNMILDRLLDKVRS
ARPLASIPEFYYTCSVGLAEYREGDGVKDIYARADEALYLAKRDGRDRVKRYTLPGSDPE
LRPDQAP
>A0A7L6BW39|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-01013|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A518JMP9|diguanylate cyclase|EC 2.7.7.65|Rosistilla carotiformis|TrEMBL
MIDTTPPLPTGQSAEKPSRVDVVEGFERISTLLGDLNRLPSGTVASRKEYDADGSHENQL
LAVRLGVATSLFYSLRCKHRQTAEHSLRVALGCSVWADRLQLSTEMRDRLEVAALLHDIG
KIATPDRVLKKPGHLNDDERLIMEQAPDVGCEILRGCCSDESLLEILRYSRNWFHAGTDS
DQLSGEDLPLGSRMLAIVESFDSMTTDQVYRRAFSQERAVAELFQYAGTQFDPDLVRDYA
SLLESRPELMYGAAARRWLQDLQGDYSNRFWSSSSPKPRSRNNDGALGQLLFHQHLLDTM
CDGVVAIDGEGVITHWNYAFERMTNIAADAMIGQAWSDTLVRWDDSRQHPGEAASLGGCL
ATGAQSRRRMRLVLPDGKQTPVKVNFIPILGEESRVQGALAIVNDISQEESLEQKVQSLH
VKATRDGLTGVANRAEFDRALGDVVEFAAAGKGPASLILCDIDRFKSVNDTHGHQAGDDA
LISFASVLERHSRDGDLVARYGGEEFALLCPGCDNATAAKRAETIRCDLERIAQPALANK
CITASFGVTEYQSGDTESTIVARADRALYKAKENGRNRVVQLGSGLREPVDVLATSSKGW
FHWLLTPSKSDQVKAKLATRVPVEMVIEKLRGFIADHNAEILKVQDQRLELRLDVRSSIH
GRRSADGVSAFHLRINLDERDVETGYQGESNLMRETVIDANVSPWRSRDRRNREVKNACR
NVIASLKSYLMADYIDRP
>A0A377LW51|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKEITSTPRPTFKSTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLATLGKQGQFAVAEVINAHKKRFAYWSWNPEENNDTLGALVS
RWLFPDPVAQPIMHNGNAIGEIRLTARDNLISHFIWLSFAVLTGYILFATAVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRSSIAALMHDASAKTNTALLFLDGDNFKFINDTWGHAA
GDCVLIEVARRMVEFGDKRHQSYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDL
HNGQTATMSLSIGFALAWESASVEALLEQADRNMYQDKNQRTKAIT
>A0A0M7JV82|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MGSSELSLLQMAVMQSWNAVVITSADRAAGYPVKIANPAFCQMTGYAIDELYGQSLKMLQ
GPATDQEVINRLRNCLSSGEYFEGMTTNYRKDGLPYLVRWNISPVRDEEGDITHFVSVQQ
DMTAYAKVEETSKILGQALDAAAQPILVTDAQAKIIFANQAFCQVSDYEESELIGNTPSL
FKSGLQDDDFYKNVKASLMTAKTFQAIFINKRKDGTLYHSEQSISAIKDHAGNITNYVSV
GKDVTERLREEQALRESATVDQLTGLFNRNHGKALLSEAYSFTLSREEPMSLILCDIDHF
KQINDSFGHPVGDQILAQVSGLLRKSVRGNDRVIRWGGEEFLILLENCTDMVAAELAERL
RLRIASEQFQNVGKVTVSLGVASLFQKESLEQLISRCDEALYKSKRNGRNQLTLA
>A0A8H8XA34|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MKAPQIPVNEAERMNALRESGLLEIDNYPAFDRLTRLATRFFRVPLAMITLVDDHAAIVK
SADGQVPATQPRDLSFCGHTILGDAPLVVSDTLLDERFADNPQVVGDPGVRFYAGFPLRL
RDGACVGSLCLIDYAPREFTAADVAVLADLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
FAQFALSVSQRRAEPLTLGWLDLDHFKTINDRFGHQEGDKALKAMATLMRSSFREADLLV
RFGGDEFAVLFADTDEPGAWIAMQYLVEQTEKYNARQLHPWSLQFSWGLSEFDHHRNDMQ
AWLKHADAQMYAMKRQHHGEK
>A0A7Z1F456|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSEDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRSRPFWQLAVDT
KRTLPINGVSDAFVEKTTLLNRDDELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTETATQTADIIPRYYHLVTQPWFTQQTERNNRARAVLWFITSPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRMLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIENNTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
GQCQAQSLPFSVVQIDLDYFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKELLVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDHDRK
>A0A411GK18|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGATIGEIRLTARDSLIGHFIWMSFAVLTGCILFATVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGNNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQAYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTTS
>A0A7Z0VI53|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MNQINSGRRTGDRRSGLERRKNQTGKQGTEHRMSWEDQRTQYWTRLLFCGLALLYFNFGG
EEQVRDWTNLQVVNLIFLVFGIEILFFMRHASRVPHAPWRQRLTMWIDIVMASFAVLADT
TISSPGFLVYLMVILGNGMRYGLRLFGEAVIGSLGAVILIVSLRLFDYVDLFSVSAVFFL
VFFAIIVIYSYTLTAKIELGRAKLAHERNIDALTGLLNQRALVERSSSLFQSQEDGNSVV
VLFADLDGFKRVNDTHGHHVGDRLLAGVADSIANTVRDEDLVSRYGGDEFLLLLPYATKQ
CGETVAQRVRQAIDDYAKENGIDFSISIGMGRYPDHGHDLDSVIRSVDQAMYRSKLKHGG
GGILHVDGGELDTAESTSGMTY
>A0A240EF73|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MTDLTYHQANELFRHFPGFLSIRNSSQEYVYINDKFTVWLRQFTDVNPIGMTASALAKIV
PKNLASMLQECHDASIDYIESGQCVPKIVKFQSLHETSYYNVLKFKVDIEGESFIYTTSF
DVSELHQEAKFFENKAYTDPLTKLRNLTYLSSIRWNKGFCIVIDLDNFKQINDNRGHSEG
DLVLLRFARCLRHSFSEQDVIVRYGGDEFVVLTHYEEEAMLHQALEKLQQVFMEDFKSYP
ELCHSIGYASFQSSLRITLKKADLAMYQSKHDKRTKKPKALL
>A0A411GIA6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTGNAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAILLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASTLRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A156QZI5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MRSALTAFRPFRPDTPLRNASTIFMLTTLFYFVGAELRLVEALSLFWPLNGVMAGIFARY
VYLNRLHYYAVCYVAMLLYDAVTTNWGIVSVVINLSNMIFIVVVAVLVQRDKRLMKKTPD
PINALRLFNYCLIAAMLCALLGAVGSVGIDSHTFWPLFADWFSEQFSTGVLVVPCMLTLR
MPGRELRLRLEQLLPVMALIVSVIASVVIGGAGSLSFPLPALIWCAVRYSLPATCLLTFI
TGATEIILVANSIINIAVATPFTTPMMFSARLGIATMAICPVMVSVSMAAINSLIRQVSL
RADYDFLTHVYSRSGLYEALKHEESYRHTRFLTVMLLDIDYFKSINDNYGHECGDRVLAS
FARQVQQVVGEDGMVARMGGEEFAVVVNSGDAQHGFELAERIRSTVASHPFTWRQQTLFL
TVSIGLGSGKAESWQLTEVFNKLMAEADDHLYRSKKAGRNRTSARVADEQIAAPSGSET
>A0A8I1YS89|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MRLSKIFTVVTLVLFVLACLPLAWIVNGEWAVYRAADEGLASIQIAHLAMVAVEKISFER
GPANVLIGSPADQDARERLRRARQTSDRALQDLVSALSPSSSAYHRQALAAVRSARQRLS
EARLGMDRVIASPRPASAGIMPSIRRMFDVVPAILEAVTALSSQASSIYPQLSHPLSGAR
MATELREYAGRLGSTLTPALAEQRPLAESETRDIHILRGRIEQLRGTILQRLNAPSLQPG
PRQAVGDMESLYFREGLAQVDDILLDSHLGRPYRVSLAEFTAGYVPTLYSIVELRDAMLT
AAAEEARVQRSAAFRHLLGAIALGVVALIAQLALFAYIRWLIARPLLAASRLLSHLADGK
LDADIPDSHRKDEIGDVLRAIAILRRNSQEKRALEHERQRLIDELTEMSRIDFLTGITNR
RAFTQAAHAEIARASLARESATLILFDIDHFKQVNDLYGHDCGDAVLVHVAAIVERVCRE
GDLAGRYGGEEFVVLACYRGASNGEALAERLRAAIAESPCLLPSGQKLAVTASFGVATLG
EAAPSLERLLQAADRALYAAKRLGRNRVMVVAS
>A0A0X1U8X8|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MYSSVDVEIRFNKVLWKSAPYSYWESGGFGFFAVRSKGPISGMATLFVQKISNMICYHSI
PLLERRNLKLFKFINNIKFKAKLNVFVALIFSLIILVSAILLYNAYLGKQDDLEFIDQTI
RNNYDRNIKDQVDNVITLLDGIYEKYDSGELTFAEAQTLGADLVRDLRYDGEGYFWIDTI
DGVNVVLLGSDTEGTNRYNFFDSNGVPVVKKCIKIALESESGYIDYWFPKANQTQPVMKR
GYVKLFVPFNWVVGTGNYIDDINKSIEDKRKDIDTAFQNQIFAISVLFLLLIIGTISLVS
FFAKSITIPLQKTTHLANLISNGVLDEHIDNNIKKRKDEIGQLATSIEKMRNSIKQLIDA
LTENAKMLELEKELFGTTLKSIGDAVISTDQNENIVLMNTVSEELTGWKQEEASGKPFEE
VFKIINEYTREKCVNPVTKALQLKKVVSLENHAVLITKNGDGIPIEDSASPITDMNGNII
GAVLVFRDVTDQKEKQKKIEYLSYHDQLTGLFNRHFFAEEIKRLDVDRNLPFTIAMVDVN
GLKLTNDAFGHEVGDLLLQSVAKVLKSECRAEDIVSRIGGDEFVILLPRTSSVEAELIIK
RIYKAMELQKVDNVVISASIGWETKESSHDDIREVFAKAEDFMYRKKITESQSMRNQTIK
VIMHTLHEANAREKIHSERVSKLCRKIGEAMKLDNEVIKELELAGLMHDIGKIAINNDIL
NKPGKLTEAEYEEVKKHPEISYHILKSADVYTRLAEYVLSHHERWDGKGYPRGLSGEDIP
LVSRIITVADAYEAMTAIRTYKGAFSHEQAIEELKRCSGTQFDPEIVHACQKYCWTRKGE
F
>A0A564V4H7|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAVDIAMYQEKKHKQKTPFVAHPALHS
>A0A737MEJ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:b:1,5|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7T5UAI4|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MSASPPMFLTVDVRRSGLRFSQRVYIPRIVGTILCALFISSVLITRPVPTLLWVLLFLNT
FIWPHIAYALSLRSRDPMQCEKRNLLIDVAFGGIWIGFMGVNLLPSALIAAMVGMNGTAA
GGIKLFVQGIVLQCVVCVMILVLFAVPVSLNTTSIQLYACLPMLLVYPIFLGYVTYTTAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDICQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKTADMALYRAKNKGRRRTEVA
>D2TNU3|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium (strain ICC168)|TrEMBL
MPHETTTENWGWLKKLARRYGPGHVVNLCFLIVMIFSTLLTWREVVVLEEAYIASQRNHL
ENVASGLDKQLQFNIDKLLFLRNGMHEALITPLNFSALKDAVSRFAELRVTQGWQLELDK
RRTLPLNGVSDAFVNQSHFLSRDGEALSNELTAALEVGYLLRLAPTQSSMAHEAMYVSRA
GFYVSTRSTPLAGEIASRYYDYVIQPWFNEQSQRQNRTRAVRWFTTPSPQLSHDEQLVTV
SVPLDSNHYWHGVLAMSIPLAGVERFMEEAIDKDVEGEYQLYDSRLRMLAASTPELRNAN
TFDARELAMLAHDIEHDTEGGLRMGSRYISWQRLDHFDGVLVRIHTLSEGVQGDFGSISI
ALVMLWTLFTAMLIISWVVIRHMVSNMFEMQSSLQWQAWHDTLTRLYNRGALFGKARHLA
QRCQAQKQPFSVIQIDLDHFKSINDRFGHQAGDRVLTHAASLISGTLRADDVAGRVGGEE
FCVVLPATTLAQAEAIAERIRQRLNEKELLVAKSTTLRISASLGVSSAQENDDYDFEQLQ
SLADRRLYLAKQMGRNRVCITDRG
>A0A4U9UJ54|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MKLLGQKGSATSRPTLGQVLQRMNLGLALIAVSAAGIFLTLLALFALRAYANHNLHLIAR
SISYTAEAAVVFEDRPAAREALMLIASNEEVSEAKILDMQGIALASWSHPADSPLHGLEQ
MVARWILPEAVVLPIAREGKQIGLVWLTGNGSSLLKFLLRGMVGMIACLMLSTLCALVLS
RRMLRGIVTSLDDITNVAHTVRRDRTFELRVPSAPIAELHELSCDFNGLLDEIEAWQQHL
QQENDALTHQATHDSLTGLPNRAFFEAQLGRALSELEPDEKLAVLFIDGNRFKEVNDNHG
HAAGDTVLITIAERLRSRLRKHDLVARMGGDEFAILLAPLKDTNDVLPIADIIIECMQQP
IVLPNKERVIAALSIASRFTLNMPLPLRNCSTKRMTPCTGQNTCPTEAGG
>A0A4U9TTA8|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MSLIAAGAYNHTATLILMDIDHFKAINDTFGHGLGDEALIVLAEELVLGLRAMDIVGRYG
GDEFGTVLPNTSAEQASLALHRIQERLNEVVFREAPELKLNISAGIADYQPEMPGYQEWL
KAADIALYRAKNNGRNRQELAVHHC
>A0A0U5I5D7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MSGPRPLPAVLTVLVVEDNPGDARLVELYLHEDPARPFKVVKAARLSEGLAALQAQPIDV
VLLDLSLPDSFGMDSLARLRTASPTVPVVVLTGTSDEALALEALRQGAQDYLVKGQGDGE
LVRRAIRYAIGRSAADAALRQSESRFRALFDNAGTGVILSDAGGNYIHCNPAFCTMVGYS
DAELQAMTYRDITHPDDVDAHRQMRDDMMAGRLDSYELTKRYIRRDGATVWARLTVTAMR
EGPDNETRFTVAVVEDVTERKRLEDHMRLAATVFESTGEGLFVTDEMRRIIHVNPAFTEL
TGYPADEVIGRTPRFLASGRHPPEFYDVIFKTLAETGKWQGEIWNRRKTGEMFAEWLNIS
VVRNERGELSNYVAVFSDITSRKQDEERLSYAANHDPLTRLPNRTLFQERLSRALTRAHR
NQSIVALLFIDLDFFKQVNDTLGHLAGDILLQQVAERLSSCIRQGDTVARLAGDEFTVIL
EEIGEPRDGAVVAHKILSLLAEPFDLQGHEARISSSIGVALYPSDGGDAQTLIKLADAAM
YRAKHQGRNACRFHSETVNALAFERLALESALRHAVERGEFLLHYQPIFDARTGAVVAAE
ALLRWRHPDFGLIMPNQFLPLAEETGLILPIGRFVLDQACRQAKSWLDAGHAGLKVGINL
SLRQLRAPELIEDIAAALETSALPPGALELDVPESAIIDKGQDVDAIFTQFKTLGVRMAI
DAFGSGYSSFSFLRKLPSNTLKIDQSFVRDAASGAEESEIVTAIVAVARGLHLSVVAPGI
ESQEQLDHLTKYDCDMVQGFLFAHPMPAEELTAFLLAGKPPASLPVKPPA
>A0A0M7FKB5|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MTTAAMPRLKLRRLVTVLALASGIIAFVNTLYAAYLVQREQLIANTLEANRAYAVKLAEV
TDIYIESIQRQLLLSAERAPGLLGSKPAMEDELARLVHQSDGVMTAAIADSSGTILATAP
ADAGFEGRTLVRQQLATGAQHLKGQISTPYVGMEGQLILAFSEPFRDAKGNYAGTILTAI
HLRQGNEFDKLVGEHFYRDGSYLYVVDGNGTIIYHKDKDRIGTSERSNAVVEAVLRGETG
AMPVVNTRGAHLLAGYAALKNGGWGVVAQRPLDETLRPLRSLTDRIVLYALPVGLTMFLV
IYLLGRWISRPLEELAQIIERDQPGASAGDLDRVKGWYYEAARLRNAVTMSQSSQTRRLD
KLNTDTITDPMTGLFNRRGLALQIATLRQTRQPFAALALDLDHFKRVNDTYGHAAGDQVL
IALAAILKTCVRGEDAPCRVGGEEFLILMPNASRDTAEMVAGRIRAATASHAMPQAVGRV
TVSIGIALWPSDDADIDKVMAKADEALYRAKNAGRDRVEVWSAGSPQA
>A0A0M7LCA2|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MKSLNRYTVAYVIGVLIPVSALIGIQLTHSWRAHAAARDAMSSLGVVQGTLEAMATVLME
RGSMNAALIEGQPVSEARQQELQLARNASDNRIAELLELHRTRSCDSCRDVRATVQHIAR
TLVQHRAAADRLIARPRALISAQELNDVVVIMAGLIPALEETALDNSAVVIRHEVESPGL
MTIAMLAAGLREQAGLLGSSFMPAQVQRRPLSDLETQRIEQQLGRVSQLRALLEVQLSTH
ADLETRAYPRVQFEYFGAGLEYIETLRHTPPSSADSPSPQAGTQERYVPLMQSIVDFRDE
VLSVLEKLLERQRVNAVTELVTTTAVAIVLLLAATWGFTKFRWRLIRPFVVATEIINSIN
DNAPAPISGAGYRKEVRGLFDAIQRLKEDAIAKSRTEHERERLIADLATLAETDFLTGLL
NRRAFHVRAVALCASLHEPEQMLTLIVFDIDHFKRINDSYGHAGGDNVLVAVAQACHQTW
RRTDIVARIGGEEFAVLCTVPSMAQASAMAQSMRRRIERLTVPADGRTITSITSSFGVVC
ARADEIRDIDALLKQADALLYRAKASGRNCVITQSDNPAR
>A0A7L5XB50|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EKINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISTINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQATMSLDDPWMMMKENHLMLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMFNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A5C6FDF9|diguanylate cyclase|EC 2.7.7.65|Rubripirellula reticaptiva|TrEMBL
MWLDLIIAMSCGGAGLACGWVMHATNTGLAALTDGDSNVVPVVTNEAIEVVEQTPERISE
VAEKLRAYARTMAADVDAHQTTVQAVNNQLNADQSGSPEAVFQAITQLIEANELMQSQLH
VAQDRIHDQALQIESAERRAETDALTRVPNRGAFDKHLARQHALGAGKAGTLALLDVDHF
KKFNDVYGHRAGDEVLRVVASILHSRLDKYGIVARFGGEEFAVILDGCRVDQAKDLVDAA
RAAIGAREIVFEDKRLCVNASAGVAELQTGEAPENWLQRADDGLYRSKEAGRNCSHWMDG
TTPIKVAASEAIAATQAKAAANSSSTSPTGEQESATDKKSVSEAVAEAKPKQKMFANLPD
RADLGETFDEVRGRTQSTVSMFVMAIRCNGESSTTGMRSLMQIVRATLRSVDRLGCDDDS
TFLVFMPSVDEATAQNRSLQICRSATAIGMGKSELPINPISIGVSQVRAGDDFDGVVNRS
IEFAEKAKVDSSEPVLIAPGE
>A0A0E1T478|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 53638|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A8J7VU43|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MRSSPHRIQWGLLVAALLFTLIGIGVYLGAQRSISDARWVSHTNAVIGRIDEIQALLREA
ESTQRGYLLTGSIEALADYRNAIGDLPRALDGLEAVVADNPAQQARAGRLRGLVQTRLQQ
LGATLDRFRTGGLGAAQRAIDAHSLDVSHAIGELGRDMVAVEKGLLARRSASSAASSRLL
LALSTLGILAGLAIVAAVYVMLRREMRQRARAEAASAEALARLEAGNGELRRSGEDLHTL
GRYAGMLQSCQNVEEAVEVTRVSLTALFPGHAGCVYLMRASRDHLERMCAWGAAPTEAET
AFLPDECWALRRSQSYLVHDSRQELLCGHVHAPAQAAVNTLCLPLFAQGEGFGVLHLAAA
GTDGTLRVEIAAAAAEQLSLALSNLRLRERLRQQSIRDPLTGLYNRRYLEESLLRDLARC
ARRTMPLAVLMLDLDRFKAFNDTHGHAGGDALLAEFGRLLQSQVRGEDVACRYGGEEFTL
ILPEADADTALARAEAIRAATRELRVVAGGRPLPAVSVSIGLAMFPAVAETGTGLLEAAD
AALYQAKAEGRDRVVPAQRGMARRRDALGA
>A0A5P9CPT1|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MSKHAEILHHSQIKQFLYKGALLAQLSLLSITLLFSPVSVANQENAESRTLIVTNSKAWK
PFSYLDDDQQPAGILIDYWQQFAKHNNVEIEFLLLDWNDSLEAVRTGKADVHAGLLWSEG
REAYLDYTPEIITIDTQMYINRDLIGLDLNDFMLGKHNYKVGVVTGGYEEEFTRNNYPNL
QLVSFNNNQKMIDAAFKGEISAFVADLQVGNFYLLTSNQPNAFIGVRNLYSGDLRAAVKE
GNKALQDRIIKGQETITTSEKQRILSRWMHINTVYPAYLAPILIVIAVGGAILYIFALRY
SVRMKTRELALANEELKKLSETDSLTGLSNRRHFVSEFQQRIEMQGDVCVIVFDIDDFKS
INDNYGHQVGDHVIKTVAEAVREKIGSDQLLGRIGGEEFALVMNNQDELRVKEVSHVICD
LIRNLDFSDKLPYQVTVSLGCAYYPTAHQDIQLSDADQLMYQAKAQGKDQAVVKNMENSH
S
>A0A3S9L4G6|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MHRVRHIPKPAALLFHIVAMLTLLLYGSYRLYLGDWMLVVIYGLSLLPLGLSFSKELKGV
SSPFNRRVTLLMVSIGIAATSLEIGYAGLIFIFPTVFIYFFLFPITEAFVLSMLFGALAL
ACGAQIEPVDVIVRFAVAGVNCVIFGAVFAYIVSNQRNALVTMAVTDALTGLFNRKKLTG
DLEEMTLGPGAALMLIDVDHFKRINDEAGHQEGDRVLAEMGRLIRASLPTNALAYRFGGE
EFLLLFPDPLLAQATCQKLQIGLKRLALPDCLQCKAPLVQHPPRQAANDEVESDLIVQKQ
SVTCSMGLAFKEPAEDIESWLKRADAALYRAKDEGRNRLCLAESSVTYKTFAPEPSEPEL
SSPASASGLEPALGADRVQSR
>A0A5P9CPL8|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MTNFVGQHLEEMADMRSARKCKIVLLCSVIALIIMAYYGLLHLSNQSYLFGITNGLCVII
LAGNLFYQRLNPSVNVSDIVLSGVLLFQAAMLLFYGEHITDRLLWLFPILAAVILACEFK
TGLMISVSSYLLIFVVCVFTDLVVVSGQFAVDRFLISLLALSVLCNTSAYFYAKVASYIQ
SLYKEGIEDLAYRDQLTGLANRWSFESWALGKLEQVRDNETLTAMVFLDIDNFKMINDTY
GHEIGDRVLQHFANRLKNNIRTKDRKTQRNDYSIARFAGDEFVLLLYGVNSVEDLNRILE
RICHLFEDSYQSTERINKLTVSAGVALFPDDADSMLELTRCADKAMYSAKHSGKNQYRYY
NPHQCDSLDSEEELGLGKVTPLKTARPNDS
>A0A644WSU2|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MTGLYNRAYFEELFDKLDKHTSCKVGIIVCDLNGLKMINDNYGHKIGDLLIKETGNLLNK
YSSENIIISRIGGDEFSMVLTDVNESDVLDLVNNIKNDIIEHNEECKEIEINMSIGYSTS
PYSIGFMNDIFVVADQNMYRSKRKDKMDDYEKLKLILNY
>A0A644W9D8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MRRDIQRMLDALKEGAYFVDRERRITYWNKAAERLTGFRSHEVIGHRCSEDILVHVDCEG
KNLCKAGCPLLATMEDTLTREAEVFFHHRRGHRVPVSVRTTPLEDDEGNVVGGIELFAEI
SPEENLRERMAELERRSLLDHLTRVPNRSYLDLELEALFTLWKKSGVPFGVLFFDIDHFK
RFNDNHGHDIGDMVLETTAKTLVSAVRSFDVVGRWGGEEFVGLFPNAERETLASIGERLR
SAVETTWIEVDGQQLSVTVSIGGASAAKEDLSAAAVVKRADTMMYRSKQEGRNRVTVG
>A0A644SVK9|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MEKEALNVLPSDMLYSNILECASMNLMLVDLNSNLVIYANKACEATYGYSAEEFIGMTIA
NFSCNDNNKIQREIQRVIKRAPEIYRVLVMHRHQSGRQFPVEVLAKLIVINSRRYILYQT
TDITRHTKLQGRINNIIRYLSTHAYRDYLTGAYNRAYLYNVYLPRLIGCNIGVLIIDIDH
FKTINDKYGHEGGDLVLSTTVRLIRAALRQKGKIFRFGGDEFIIIVRDMEMPEMKMIIQK
IKEVIDTTPILYNQGRIVCSISVGKAKGYVVENNDLDKLIKMADGEMVKSKSLRPIL
>A0A645G2C6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MNRNGFQVDLEREYADVSGLGVLYFDLNNLKETNDKYGHAAGDALLRRIADVLRLICAQL
KHAKCYRVGGDEFVLLLTQSTREALKYCAEMFGDCMDNHNQNETLPCSVAVGQAYSEGPC
NPEMLVSQADHAMYRCKQMMKDL
>A0A645HX48|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MADIDFFKVVNDTYGHLIGDKVIRDIAKLIQASIRKDQDWVGRYGGEEFLITLNNTDVKD
AFIVCEKIRKIIENTTFEYEEAKVKVTASFGVYGIVSTKLDIEGFINAADKSLYAAKVTG
RNKTVISENI
>A0A2K4ZF18|diguanylate cyclase|EC 2.7.7.65|Acetatifactor muris|TrEMBL
MGTYNFSDIFDISALQGLLESLSAALGVGICIRDQHGKYLFRSRECGVCCDLLEEAPVGS
DEQAPETVYQAFTPCVRYCQAAGLTDAVIPVMNDTVLAAVIQVGWVRLSEQEIDDAEYLT
IARALQLDEEQFLESVHAVPLLTRTHFDNILNAVSLIMEHFSQLGHKNMYLKSVISSLES
QEFLHQQEKNVLANLAEKDSMTGLYNRRKFEEVVALYARLKTRKICMISADANFLKLTND
IFGHESGDHLLQAIAKIMNDLAKSDWLVARCGGDEFRVVLPDTTLETALDYCRRVARNCR
RDKSLALPLSVALGAAEWNSEKETLQDCFSRADAKMYQNKTALKHELRIPNYIMERLYDR
QVLSKEVVEFTASLTLDFALYLNFTGEHAKEASLAAHFQDIGMAKLPESAAIRGQSRTEE
ETTQIQMHVTHSYTMARQFDELYKLADIIHCSHENWDGSGYPSSLKGDHVPIESRIIHLV
SDYARRTHPTVTGGYYSEEAMKDRLARESGSVYDPNLVSRFLEFLQTRELH
>A0A0B1RF01|diguanylate cyclase|EC 2.7.7.65|Pantoea rodasii|TrEMBL
MPNSPLSPRAGNPFLPVHLCFLAVFLFSSFLTVHEALELKNNYEERQRAQLSDFQKNLDS
QFQESLDELMYYQKMLTYALTHPLDSDHGREASQRFQQLRQQHTWQLRIASPRSMPLNGM
SDSWIEQDPLLRRDSEHIAQELRAALEFSFIMQFGDPEQEFHSRFWYTSRAGFFISSRPP
QSPQELEETYATMVKRPYFRELDPRNPQHSRLRWTEAYQGLFNEGLMITVSAPVVSGDYW
YGVLSMDFTQQRIHALLNEARQSYLQGKLLIVDRSMHEITRLSALHDKPLTDEQQARLEQ
QMRLHPAGIMRLGTQFTSWSKLTNVDAYLVNIQSLKQGIAQPLGRVALFLFGTWLLFVVL
LLVSHQVIFRLVRRMDDLSSKLTWRANYDGMTRLLNRNAFFEQFVALAAHNKQQQTPMAV
IQLDVDHFKNVNDTWGHAAGDQALIRVAGVISHTLRKYDIAGRIGGEEFCIVLPETTLAD
ASAVAERIRTRLAAKTILVNCNSTFSITLSAGVTGSEEQGDYDAESLQATADRRLYQAKT
SGRNRVCAEG
>A0A1G0DT87|diguanylate cyclase|EC 2.7.7.65|Gallionellales bacterium RIFCSPLOWO2_02_58_13|TrEMBL
MIQLKQSIDFIADWHRLSAETPEPVRRLAGEIVRQHTVALADIFYQNMLSDEQAKSFLDH
ELVNQRLHVSLQRWLQELFSGEQHDPQTIYEQQCHIGEVHARIQLPIGLVMRGGRLLKHA
IHSYLVESSLERGDLVKAANFVAETIDLALDAMTDYFVIDMEKHARADEAYRMFALGQNM
LAERERQRAAILEWAQQILLKLLADGSAAQLPDIKHSEFGMWLQHKAAIIFESAPELEQI
RQRIDEVERSLFPKLIESRRNPGGAGALMKEVETGIAEIKFLLGGLFDRFIEVESGRDAL
TRLLNRRFLPAVLIREMALARRSAVPFSLLLLDLDRFKLINDTYGHGGGDMVLQQAADLV
TSSVRAGDFVFRYGGEEMLVVLVEVGSDQALRVAETIREKFAADAFRVGDRQTAGVTVSI
GIATYNGHPDYETMLKDADAALYEAKDAGRNRCVMSGR
>A0A822PG21|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A380T9Y9|diguanylate cyclase|EC 2.7.7.65|metagenome|TrEMBL
MRYAHSFEKAVAYAKKAFEQMLARDVPPHPNNFVVWYTYCSGEDQELGKVLDILIDNNQE
FSEERNAAVYNKFCSSPYEAVPMHLIAERMEAELTAAVSVLEKTGRDVSPYGDSLQEVRT
KVREARCAQDVVQLLTGMLTQTRAMASQSREVEGQLRQSWTEVSRLREELEDARREAMTD
ALTGLANRKMFDFMLRDTATAAMEAGLPLSLLFLDIDHFKNFNDTYGHTVGDHVLKLLAT
VLRDTCKGQDTPARYGGEEFAVILPQTTIQQAAALAESIRGRVAAKGSVHRKTGEQLGRV
NVSIGVAGLIYGESMRQFVERADHALYMAKRTGRNKVVVQDGKLDKKSIALAP
>A0A5P9GNL9|diguanylate cyclase|EC 2.7.7.65|Erythrobacter sp. THAF29|TrEMBL
MSDQVLGLITPGMSFIFAIAGLVLWLRNRDAVHLLGFAVAPTLIGLSFTVNHYASAPNAV
EIRILVGFLSMSAVITMAWAACNRMGQRAPLAIWIAGALATACVLLVSDPARDVSVWLFA
LNGFCGIVFVMAAQIMARSGSCEFADRALVFVISLIAIQFFIRPIGVVLYTGPMNSVEYR
ESVGHAVLMASSAILMLILVATIIVALVTDQLRTIHDDANSDPLTGLPGRRAFEEKVGQA
LSEGEDDCVPTCLIVADIDHFKQVNDLWGHQAGDRAIGSFGKLISRTIRQSDIAGRIGGE
EFSLLVSNCTQSQAARLAERLRKSFAALQHEGINADIRLTASFGVTAIHGGEGYARAFSR
ADRALYEAKEAGRDRVVVAESGRKSGAGAAEQQARANAA
>A0A5P9GRB5|diguanylate cyclase|EC 2.7.7.65|Erythrobacter sp. THAF29|TrEMBL
MVAALGGLRGLCAKPARMSNLLSSIHAFPVGTAGIGLPVMLSNETILASVCLALALVSLV
LLAALVAARRDTRFVAELARKRAARINEFVRTACLAEEIAGIGIWECDPATGRQQWSDGL
RKIFGVEGDEPLVDGDAETMLFANNIDLVHAVRERLDKDGPYQLHYELYGFDGELRSIEV
KACNLKSQSGGTDRVVAVVRDDTDRIERVRELEFSRAAAVREASRARELAATDPLTGLAN
RRSAMERLDSLIVDARRSTMPLVLVVFDIDHFKSVNDTYGHVEGDKVLKKVAQIAQDQAR
EDDVIGRVGGEEFIWVVPGATETIARVMSERLRLAIAEGSSTDKVPAVTISAGIAELDPQ
DTSLTLFARADSALYAAKSKGRNRVQLAA
>A0A660G996|diguanylate cyclase|EC 2.7.7.65|Klebsiella pasteurii|TrEMBL
MDKLIWVEKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYFANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFAALRKAEEDYLTKRHDPIWSVEIHNRRTLPI
YGVADAFVDGDALLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
ELPKNSTQALALYSRATGAAWFTRQTQRNNPARGIVWQTFPDDESQREMQVVTASIPLDF
QRHWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTFMLLISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERAIAETRLSERLK
RPVAVIQLDLDYFKSVNDRFGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TPLKEAKVIAERIRIRINSREILLGNSTSLRITASLGVSASDDTGEYNFENLQSVADHRL
YLAKQDGRDRVCAEG
>A0A2H5YVB3|diguanylate cyclase|EC 2.7.7.65|bacterium HR26|TrEMBL
MIVTAAQPVYLSSGDPDYPIIYISPRITEVTGFTPDEFRAIPALWFRRIHPDDKPLVAAE
AARTDATGEPFKVEFRFQRKDGRWVWLENNAIMLRDQGGKPLYWHGLLTDITERKRSEML
LSGQLRILERIAQQAPLSEVLEQLCRLVEEQAPDLLASVLLLDQEGRLHHGAAPSLPPDY
VAAIEGLPAGPNQGSCGTAAYLREPVVVTDTAVDPRWAAYRDLAQVYGLRACWSVPVVAS
TGEVLATFALYAQEPRGPEEREWRLIELATQLAGLAIERWREQEQLRYQAGHDLLTGLPN
RALFLDRLEHALARAARDPRRVAVLFIDLDGFKQVNDLLGHQAGDELLVQVARRLETTVR
AGDTVARFAGDEFTVLLEDLQSLEDAVVVAERMIRVIEEPFVVAGRVVGVSASIGIADSH
PGLTDPGALLLAADQALYAAKRAGKARYMVAM
>A0A655YQS9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVEQATGVDIEVLTCKNDAPLPQDEVDVSYIKQLDYSGNSSVLFKINHHIKHPPFIRTEE
ILALLFFSLVMYLVNLWVVIALIKPITTASQVLQQFKTSGGKMPDASTFISSEMKEFATT
INRIVGQLEDSQQVLRWQSEHDPLTRISNRRHLEKQLKSYLSDRPQAYLVLFLVDIDFFK
RFNDSFGHLAGDEALCSVADVLQSVEFHGEKIVARFGGEEFCVVLASDCAFDAEQYAQQM
RSKIEQLAIANPVDALCQYLTVSIGGVYAISPKMESYLSLFHQADMALYHAKEHGRDRYV
VRNFV
>A0A655Q296|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDSFAGNQLKEMTEMRFARKQHIVLISSGVATAIFLGFALYYYFNHQPLSSGLLLLSGIV
TLLNMISLNRHRELHTQADLILSLILLTYALALVSNAQHELSHLLWLYPLITTLVMINPF
RLGLVYSAAICLAMTASILFNPAQTGSYPIAQTYFLVSLFTLTIICNTASFFFSKAINYI
HTLYQEGIEELAYLDPLTGLANRWSFETWATEKLKEQQSSNTITALVFLDIDNFKRINDS
YGHDVGDQVLKHFAHRLRNNIRNKDRATNQHDYSIARFAGDEFVLLLYGVRNLRDLDNIL
NRICNLFVDRYPETDMLNNLTVSIGAAIYPKDAITLPELTRCADKAMYAAKHGGKNQYRY
YHDAAFPPAVETVLGSQPVEAPNVTPLKKAH
>A0A5E6QK35|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRGDKVRPTLRSVIGRGHLILALLAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVANAEVFDANGKLLAQWIRPDTGMLSRVELELAHTL
LEQPISQPILHQGRAIGSTHLTGHGGSLLRFLLSGLAGILICTALSAWIALHLARRLLRG
ITGPLQSLAAVAHAARSERDFDRRVPPAKIAELDSLGSDFNALLGEMEAWQSHLQSENES
LAHQANHDSLTGLPNRAFFEGRLIRALRSAAKVKEQVAVLYLDSDRFKEINDSFGHAAGD
AVLVAVAERVRAQLREDDLVARLGGDEFAILLAPLHKVEDARRIADKIIASMDLPIPVPG
NTQVLTSLSIGIAIYPDHGATPGALLNAADAAMYQAKRLSSGGQQTAESEHSAANVHHRS
>A0A174YUQ5|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MKTKKYESIMNKAMKAAMNYENPDDQINEFIRFFGEHIGSERIYIFEDNIRKKVTNNTYE
WCADGIEPQIKFLQNVDMSIIDWWYTSFNDGRNISTKDIEEIKDEYPAAYELLKVQNVKS
LAVSPFRYKDEIYGFFGVDNPPESEMDEISRFLDMIGTFLVLLLKQRNVFKKSKREAMFS
AYSALAGIYLSMHIINLKTGEFHEIKSTDFIRDNMIKGEHTFAEQINSVMKILPSRKYVE
SVLEFVDISTLPERMKNKTTIVHEFLGNYSGWCRERFIRVDEDSNGELWHVVYAVEVIDA
EKRKENRLLYLSETDLMTGIRNRGSGEEAITDLIKEGTKGLMCLLDCDKFKNVNDTYGHV
VGDAVIIAVARSLQSVCREHDICMRLGGDEFAMFIPGITETKDAESFTMRVFAKLKDIRI
PEMGDEKIYVSMGEAFYKGEKDIDFDELYRHADSAMYKSKNNTGYCATLECVTKTF
>A0A0I0AB85|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A0I4HVU3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATIVSASDIRR
>A0A737I6Q8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z36[z38]:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5M9IFN1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MTLDPPTILALTVALAAAAALYLAIEWRSVREPSLLFWSAGFATITVGSTLALLRINGYL
LIGIWFANGLLVAAHCLFLLGVARFTQVRLSPRWWLLLAVWLGMLMLPTDLPWSKAMLGV
QSLLVALPTLRASFLLRPHGRSLSIGAVQLRYVLLVHGMFYVAKALSVVIPGTLIDLAAF
KGEIIQVSLVEGAMAIMLIALSMTGSERYRREQQIARLAARDPLTALYNRRALDLRAPRL
LAQVSAQQPGALLLIDIDNFKSVNDLHGHTAGDRVLIALSEMIRAVVPRGALAARLGGDE
FVILLNPASTEQIVELGSSLREQFQQLAAQTFATPAPVTLSIGATLFDQPPASLAALIEQ
GDTTLYESKRGGRDSIRLVDRTGAYRS
>A0A5M9I5H2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MPANVKLRPRMQRLLSPAIAQAELIGIFAWLAVLLVDRGGMFGWPVVLVTLGLCVVYGVH
RVVTHYVLWRALGGFYMVLLSAGFAYVVHTRPALQVFALPLAVTLVMSSAILFIVVQDFL
VCAALVWLLTWPNIQLSLYDGVDTYVFIFCAASVSIGFILNVYYLKNLRSVLLVESEFRE
LAETDYLTSILNRRAFMEGFAKLIAAGDTGYFMMLDIDSFKLKNDQFGHDVGDRILCAMA
ACLKSTPGSHSFGRIGGEEFGVLLLVDDPDLATDYALRLLQAIRCSVAPPHHYTCSAGMT
RFTTGADMSAVLKRADRNLYASKGNGKDRVYLDGAPVFHRSMSTPEAL
>A0A381H0G1|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MDKDFFPTTRPTFKRTLRRINMISVLVTMLLIWLLLCVASVLTLKQYAQKNLDLTAATMT
HSLEAALVFSDGVAATETLAALGRQGQFSAAEVRDKNQKVIASWYYDAQASDDKLNGLIS
QWLFPLPVTQPVWHNGKIIGEVCLTARDSLIGHFIWLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITDVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNSITELMNDSSARSCSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNHHQPYRLGGDEFAMVLYNVHSEYEVKRICSALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADRNMYQAKHQRSERSIK
>A0A5F1EYQ6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHAT
GDQVLIEVAKRLAEFGGLRHQAYRIGGDEFAMVLYGVQSESEVQRICTALTQIFNRPFDL
NNGHQTTMTLSIGYAMTIEHVSAEKLQELADHNMYQAKHQRAKKLVK
>A0A454ERZ5|diguanylate cyclase|EC 2.7.7.65|Salmonella hadar|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0J9CUP0|diguanylate cyclase|EC 2.7.7.65|Sphingobium yanoikuyae|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A098GGM4|diguanylate cyclase|EC 2.7.7.65|Tatlockia micdadei|TrEMBL
MKYKVSTNGISTQLDKIAAQRDELISKIKKYEKLLKEQPQSILQYLEKISTPFYQLSIDL
KKITYINPAAEKLINSSRQEIYQNPNLWFQSICEEDRPTVIQALQDMVKNKENEILLEYR
IKIPDETNVYVADRATLINDSQGNQICIMGFISDLSGLFTARREMLLYDQILNVAHTEKS
IEIAIEAILRISCLSFGWDEGEVWLIEQSTNSLYCIKIWHRLHDEIKEFYEKSYQLKIDI
KEGFQGEVIRSNLPTLVTDYGKNKQFIRGDFATKAGLKSAFGLPIRHQGKILGVLMYFSK
SLKKLTHEEINTSEKISTILADVIQNKYSKDQMLYITHHDNLTGLINRVGLEEFLKAEII
KNTNKPIALIMIDFDRFKKINESMGFDVGDSVIKNIATKFNEYLSDVFSTIANIGGDQFV
FVLSDIKRPEEIAPLVERIKSIVKTPLMINDKSILLAISAGVSIYPYDGEDFLTLLKNAD
VALNHAKSSGGDSVQYFSEILQKTATKTIELEDSLRRALVENDFRLYYQPKVDLKSGNIV
GVEALLRWQSPNEGLLLPGSFITVAEQSDLIVYIGEWVLLEVCRYFPFDHLHIPVSVNFS
ARQFQIQHDIVKVIKLILEKLSLQPSYLEIEVTESQLMSDPARSAEVLASLRKMGLSIAV
DDFGTGYSSFQYLKQFKPNRIKIDKSFIDGLPADRENAGIVKAIIALCKSLDIKVIAEGV
ENADQLRFLIDEGCDEMQGFYFSKPLPIYDLIYLVDSKKKLNYVKNK
>A0A0A8VDB3|diguanylate cyclase|EC 2.7.7.65|Yersinia ruckeri|TrEMBL
MAGIFITLFAVVALRVYVDHNLHLIARSISYTTEAAVVFGDNIAANEALAVIAANEEVAE
TKIMGANGKLIASWTMPENGPFHQIEQSVARWVLTGSVEMPITRGTDRLGTIIMTSYGGG
LVSFLVQGLLAMLAGLIISIVVPYFSHAVCCEGL
>A0A181Y057|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MKLAGPHPDELRRLQSLRASGLLNSGKEERFDRLTRLARTLYDLPVASISLVGENTLHVK
SCAGLDVDTLPRDITFCAHTILQTDPLIVNDLQQDMRFHDNPLVTEAPFIRFYAGYPVQL
PDGATVGSFCLMDHKPRAFSGHEIQILSDLAAIVEDEFKVLDAATADELTGLFNRRGFLS
LAEYALLTARRRSEPASLVFIDLDRFKLINDTWGHEQGDKALTAIADVMKSTFRESDLIA
RQGGDEFIILLANTAQQAANKAMEQLSQNVAEYNQQAGNPWQLAFSWGCVEYDPHEHHSL
NDIVAVADRRMYQAKTSHGAERR
>Q1Q678|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MNSKNQKPSMYDVSNFTIRDMTECCKVVRTIGKGAKNMEEVANSIVNHLYVNLIDGQSGN
KACSLVRFFKTHTFAKLDPELQNFSKNVSGNSTVFPETKCLTLLATVGENPAWNSRKTSK
GHRAIPLLSEEMVDQIPMIKNLIAQLGLDTDMVIKPDPRFLLSKNDKMYNVFCIPEALGS
SCIPAQKEFVIPYGIKSVIGFGGLFPSGDIFAIIMYLKCTITNKVADLFKILAPNVKIAV
LPFEDTVFAQSAKAFVRTAEIQKLKDQIVAMEQLLEVYEQSVIVQTMKLQKEVSEHKEIG
ETLKDRERFLQTLMDAIPAPVFYKDEHGKYIGCNSAFEDFLGMREAEIIGKTVYDVAPTE
LADRYHEADTALFNRRGSQVYETVVKHSKGSVHNVLFHKAVFNDREGKLAGLIGVVLDIT
QRKLAEEMLRHRTNFEKTVAAISRRFITLSDFDAAVNASLADAGRLCRAGRAYLFKSRDN
GTIMDNTHEWCDSGVTAEMNNLQNIPVIAFPWLIKNLQEGKVVHVEDVSEMPDEAIAEKI
EFERQSIKSILVLPIYIEKKLLGFIGFDNVRSTGQWSEDDVTLLNIMSEILGNAIARVES
EKLISHMAYHDALTKLPNRNLLYDRLKVAMAHAIRSKNMVAIIMLDLDGFKMINDSFGHQ
MGDLLLKAVAERLMQCLREGDTIARMGGDEFIIVIPDLAQTEDAALFAQKILEAFRLPFL
IEKHELHTTASIGITIFPLYANDSESLFKQADVALYLSKAKGKNTYQIYKPGVT
>A0A2C9CAD3|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MNNPILVVDDSKHVQRQIEIFLIPEGFSRLFFVNSAQEAFHLLGLDDENSKNRKCEIDLI
LMDINMPGTNGVEACLKINATRHLKNIPIIVITAEDTDEGLKQAFGAGAIDYIKKPLNPV
ELIARVSSVLKLKKEMDERENREKELLTLAQVLEKTNQELQQANEKLHQLSRTDSLTGLA
NRRFFDEMLHNEWKQSVRLAKPLSLLMIDIDFFKNYNDTYGHQKGDECLKRVSMAILSAL
KRECDIIARYGGEEFVALLSDTDESGAVMVAKAMQSNIEAMNIPHKDSNASGRITVSIGI
SNEVPSAASSPEKLISKADKALYLAKYEGRNLIKW
>A0A7H4PC98|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MARHNRKLSFTTPIVIGFAGILISFLLIAVFATMTQRKDFLEDYHHINRNFTHNMATNYT
ETLLRGNDFILTRATTFFARNDELNNAVNVNPEKGLMQLMQLQNMMQTVSSISLADTNGH
YLRAPEVLETEDSQSFDAKSRPWFIKQAQASTFSLYTSPYIDYFTHHPTITLYKPIISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSEALMD
RMTSGEGQLYDAVTDGWYYYYSFTNPDWFVIYRVDNSTLVNLTRHETDIVAWSFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHHPFSLALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAVIFSDEHIDNALRLLESWRASVAQRSWREEGLTVTFSAGLGEW
NMEPLEQLVVRVDEALYKAKQQGKNRIVRT
>A0A0T9WL15|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGSLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A8F4X2L1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MSIDPPSQPDSDVYKTLLESTKAIPWRIDWQSMTFSYIGPQIEPLLGWTPQSWVSVDDWV
ERMHPDDREYVVNFCVSQSRAGVDHEADYRALTANGDYVWIRDVVHVVRKDGEVDALIGF
MFDISERKKTEEHLVRLQKQLEEYSYQDGLTGIANRRMFDTVLEREWASAQRSQLPLSLI
ILDIDFFKQYNDHYGHIKGDECLRQVARTLSQAANRPRDFIARIGGEEFVWLLPETDAAS
ARQVAQRCLHLIRQQQIEHGFSAVSNLLTLSLGVGTHIVKPDSPMLEFVEKVDKLLYQAK
RNGRMRAEFATGEV
>A0A1Q8YNH9|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A379RYS8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MKDNSACSSSALLFLDGDNFKYINDTWGHAAGDRVLIEVAKRLAEFAGNRYQTYRLGGDE
FAMVLYGVHSEYEVQRICAALSQLFNRPFELHNGQRITISLSIVFALTWEHTSAEKLQER
ADRNMYQAKHQSSEHPLN
>A0A384ILT2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A3Y0D650|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6D2G8F3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLVRRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A484Q9I9|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MKHSTEVMALDWAHTHSRYSAEQCQLAQDVSARHTAALADDFYDCMLADQGAAFFLSHEL
VQTRLRHAMQEWLLTVFDARHLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLTRRM
HELLHAEPDALPHAVLGACRYISEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSANLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHHPPGSAQRAQALQGIRDATQAVAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPLSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGPQALSVADALRRRVQERPVALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAEDDTDMPSGAPASHAAGHQPVRAGA
R
>A0A127N1V6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MDDRYRAPQDLDEALLALLHSRAEVERLKEREQLFSALLASVNAVLWAFDWQAQRMVYVS
PAYESIFGRSAALLLADYNEWLNAIYPDDLDYAASSLLQVLERGAVEQREYRILRADGEV
RWLSDKCFISQHSEAGLPLMVVGIAEDITDKKHLESELQRLATTDVLTQSSNRRYFFDNA
EQAFNESKQAGTALAFLLLDVDDFKKVNDRYGHQVGDRVLQRVAQCASGALRRGDLFGRI
GGEEFAVLLPGCDQVTARQIGERLQREVQRLRFKEDEQTFGISVSQGLTLLQPHDENLSA
LYGRADAALYQAKRNGKDRIEQA
>A0A3Y8D2R6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPRAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A398Q5L2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A4P5F1T1|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3X9TV05|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVEPPDPPDERQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>W9BHA2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHQQGG
>A0A377YGE8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRTAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A7W2WKV3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDSAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A3V7INM7|diguanylate cyclase|EC 2.7.7.65|Salmonella rubislaw|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2V3KJF8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQIFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A3V5GWE6|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0J2G427|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A1U5DUI2|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQ
FSDTGPRSMIGRVIVGLCAVGSLGWALRWVVGPWPSLREAVAFVAFADIGIAVACWQDSD
PLAGLVGTVLFTPVGAYVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVK
VTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPL
DGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLVDVAHALTCGTTGTSVVGRSGGEEFLVV
TVCPASAVAEFATRLREAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACAD
RAMYEAKHDGGDQSRILHADHDSEGRYLWRSGA
>A0A1T5RRZ5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MVTTYPGRNGFGSESNRCSRGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLA
ATGMSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVA
FVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTML
LANLFAGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVV
VVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPHI
DYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAK
KAG
>A0A827L6L3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLFDNSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSLDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A061K2U8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A853T074|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MSARMSNKPARKPRPTLDSVLRRAHLSVSLIAVLAAGLTLTAVALLALRVYSDQNLRLVA
RSMSYTVEGAVVFGDSLAAREALALIGVNEDIDQAQVSDQAGKVLARWERGEHGTRYYIE
RALTGWMLPDSLTFPITRNEQAIGSIRLVPHSRSLLPFLLSGLTCLLACLVLSLVVAVRL
SRSMETEITSPLRHLAETAHRVRRDRSFELRVPPANIAELNQINDDFNALLDELEAWQSH
LQKEHASLSHRANHDSLTGLSNRAFMEAELERAILEARVGNGKVAVLFLDSDRFKYINDT
FGHASGDRVLVTIAARIKQQLREGDLVARLGGDEFAIVLKPLRNSSDAMHIADNIIAAMA
QAIELPTGNSIVSSLTIGVAVFPDHAIDAISLVGAADEAMYRAKQAQRGTRQVARLPQPH
IHP
>A0A827B3T3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTL
VSHPPSGWWWLVLVGWAFVWPHLAWQLASRAIDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A0H0RXA0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A1X0YRU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDKNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NVLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGKLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6G6KW29|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYGVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A066QER2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A828M9B6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAANAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0H3NCL0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain SL1344)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A826YPD7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVRAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIVHGIASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X7H553|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHLTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHHRAEKLVR
>J7QQZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0J2DQB4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LRPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2K3TKG6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLYGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A376K1X3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTDIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376DK57|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVLIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3A3E5M3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAHDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2B7LRF7|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAKQSEVSPEQRRAICEAFESANNTHGLNLTAHTYAGLHGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVARQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVTRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPKKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A6D2FBU3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLYVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3Y2D9Y7|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A376DKR9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQS
EDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VLRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A5W0E3L3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium var. 5-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2J3CUG7|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNKDFSQTSRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIGLLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQMLK
>A0A5A4S6C1|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MEKPLRLKLKKLYHLTRPAHVVNICFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLSQRHQETWRVALPNRRTL
PVFGVSEGVVRDHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTYYSRAISALWFTRQTQRNNPHRGVIWQTFPDDDPQLEEQVITASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMQGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMAVASDCQR
SGRPLAVIQLDLDHFKGINDRYGHQAGDRVLSMVASTLAGTVRDGDLLGRVGGEEFCVVL
PNTTLQEAAAVAERLRLRIHGREVFLHNNVTLRVSASLGVSGSEERGEYHFEALQSVADG
RLYLAKQNGRNQVWYRSEA
>A0A5I2Q7P8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cotham|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2T9IA96|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agona|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Q9MVI6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Karamoja|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0D7EAU7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MRLASNQGDSGMGMLPGGDAQTLLALMHARAEAARLGEREQLFSTLLGGVNAVLWAFDWQ
AQRMIYVSPAYERIFGRSPALLLADYGEWRNAIYPDDVEFAQKSMLAVLDEGAVETREYR
IIRGDGQLRWLSDKCFLGRRADRGQGPIIVGIAEDITEKKQLEGELQRLATTDVLTQSSN
RRHFFECARGEFERARQFASSLAFLLLDIDDFKRINDTHGHQMGDQVLQKVARCGAAVLR
QSDLFGRIGGEEFAAVLPGCQPDLAEQIAERLQREIERVVFTADNGERFRVTASLGLTYL
KASDPELSSVFARADAAMYTAKRLGKNQVIVG
>A0A748YAN9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPMPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Z3NFW5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEWEKK
>A0A3I6AH17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A734GWV1|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGHFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5T2MNS1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V5W197|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ohio|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5H9C4M1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rissen|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1E3AC63|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MLIDPIEKELKKLQEENSRLKILSEVDGLTGLYNRLAGERLINDRLQKNAGGNFMVVDVD
GFKKINDQYGHLFGDDVLRGLAALMKEIFGGENLVGRFGGDEFVIFTVKEWDAGKAIEKG
KELIRRMEAMGRKMGVKDRFSATIGLSAYQDKDTYSSMFSRADFALMQGKKSGKSAVYYY
RELHNESRPVAAAESKGAEDTGIDRDMELIWMDLREKGRPQGAYCQDYQTFKRLYRFVER
GLMRVPSSAYTVLLTLVDDKKEYVTLQDQEHLMTGLGEAIRRSLRSGDVYTQYSSCQFLL
MVMGTSLENAWKVVERIRNNYSGEAKEHSVYIGSNIRPLQSADKGMTQIGDGRKLM
>A0A379JQA9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MKPAHWQADLQQVQQLRLFHNVATSSLDQLLREFRACELEAGEVLLSPFNRNQHLYLLIE
GQLRVYLGSLDNQAVSTLEVGDCAGEISFIDNEHPSAYVVAERPSIVLRLHRESLVALFQ
QSPQMMQNLLELLCDRVRQGNRQILDSEQNANVDTLTGCFNRRWLEHVFERETTRCAFND
EPMSLLMLDVDHFKAYNDQHGHLAGDYALCLVAHTLSSQLRPKDSLIRFGGEEFVILLPE
IADEAARGIGERLRIGLEQIASFYSPVGVLPGVTISIGLAQMQHQDSLQSLIARADAALY
QAKQQGRNCLCG
>A0A8E6N689|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium str. CFSAN000648|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8H9ILL8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes pakistanensis|TrEMBL
MPQPNIEEAAQDWHGLLQKVPPAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHD
QVHKRLHRSLRSWLIQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFFFESPDITPEQAWECFHYVQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNEATPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMGLIDTELLPAFEQDGPKGQIQRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTHGHDAGDRVLRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDAEGAMRAARNLRLRIHAETFRVADSESLNITASIG
VALYDAHPDYERTLRRVDRALYQAKEEGRDRVVFV
>A0A8E6JKT5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium str. CFSAN000648|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWGHATAEKLQELADRNMYQAKHRRAERSLN
>A0A518C0J8|diguanylate cyclase|EC 2.7.7.65|Mucisphaera calidilacus|TrEMBL
MIRPENDIIHKLAPQDHTNTRVLIIGADRENKTDWERALTQHQTGQHINWADGIEKARHL
LHGPDLAIILLHHEDDPVIDLITHWQNEAHTFPVLVIADHDLAHLAPATIRAGACDFVIR
TDNLLNILPTIIEKNLEQHRLREDHHALQAQLRATLTQVKLKNQQLEEAVTLLETAAATD
PLTGLANRRAISEALERGFAEAQRYNRDLACLMIDLDGFKQLNDAAGHAFGDLMLRELAR
VLKSNSRRSDCVGRLGGDEFVILMPETDEQTARQVADRIAGEFAVASRAQLLRHGQKGNA
SVSTGITTRLASNARRPEQLLVIADQDLYAAKKKHHDRDAASRHAHPAVELRLTTNPDND
D
>A0A8G1HM84|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MPILTQDPQQTPGGALKRLSLLKAAVLFIATVCLCLCGLLYLQLEQSRRHALDVAQVASS
NLARAMAQQAEDTFMKADLVLTSLVDWIQVDGYGAAQKPRLQKTFARRAQALDQLHGIFL
FDKQGQWVVTSFDDLTRGPGVSDREYFTFHQQNASTLAHIGPALRSRENGEWIIPVSKRV
NDKNGNFQGVVLAGIKMAYFDQFFKSFSIDDNGSMFLALTDGTLLARRPFVESQIGTSLA
KGEIFHKLLPNAPAGNAMISSVIDGVVRLYGYRQLDAYPLVVSAASSRDSILKDWYDTAF
QSCVIVALVVLGVGLFGWVFVRQVRVGVRVEADLRKAKEALKLIATHDSLTGLANRRLFE
QALDIEFGRGARQSSSLSLIMLDIEYFKRYNDAYGHVAGDHCLAEVARAVKGCCHRKADL
AVRYGGEEFAVLLPDTDIHGALVIAEQIRRSVMDKNITHNGSPTGYVTVSLGCYAFVPTG
RDSIELFIERADAALYQAKHSGRNRSAVLSLEGGVEALMRSDR
>A0A8G1HP38|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MGEASNIEPLKFNVSDLNEDMLHTILELVSDGIWDWNANTGFVYRNPGWYVMLGYAPHSL
DNTVFTWENVMHPDDYPRVMALFDAYLNQHAAGYQAEYRCRKQDGSYIWIEDRGYVLARN
ADGSVARMVGAHRSIEDKKRLFEEMERRNQSLEAIVEERTRELSRVNQQLQIQLEENRKL
AETDALTSIANRYRLEKTLPQECERAQRFRQPLSLIAMDIDDFKNINDHYGHALGDAALV
QVVKTVKRCVRYGDLLARWGGDEFILILPNTSLADARSFAEKIRHGLSSMPPVGEFQVTM
SFGVVQRFEEEQQTGLLARADQALYRSKVAGKNVISG
>A0A5C5D1N9|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. B2|TrEMBL
MINDHSSGRWLPGGIMDSSTYLNEDRHRSGRRFARRLYVPRIIGLATGFFCVSSVLVTQP
VSGWWWLLLVAYGFIWPHFAWQTADRSSNPARAEIRNLMIDSLMGGVWIAVMGMNALPSA
LIMAMLCMNNVGCGGVKLFLSGLGVIVLSSLLTLSLLHIPLNLQTMPSQVWICLPFLLVY
PTYFGLVSYRTALKLSEHKRRLMHMSTRDGMTGVYNRRHWEHLLHGEYDNCQRYQRNATL
LLIDIDHFKSINDSYGHDVGDEAILAITEHLQLTLRITDVIGRFGGDEFGVIMSGTPQES
AIQAMARVREYLQEFHLPHAPLISLRISVGVAEFDSGMVNYREWLKAADVALYKAKNLGR
SRTEVADIAA
>A0A377RJG9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MDSLLKHMVDMTGHRDHTMLDISVISAVQELAAASQTRVLALTTVRGQVFVRSRAIIVAG
SVARMEEHNDPTLPGEPLSDYPALAACIKRHEASADTLCADGRHLLWLPIWIGDQVTTCL
EITNPTPYTGATIQVIGGIVSVYRNFQNLLDYSERDSLTGLLNRKTFDDQLAKILHSRGE
PEAEKPRPVDEERRHHTDTERQWLAVIDVDHFKLVNDKFGHLYGDEVLILIANQLQSSFR
SQDRIFRFGGEEFVVLLRSITLENAQKIIDRFRTNVEAHDFPQVGRVTVSVGFVSINAYE
APVIILGRADQALYYAKSHGRNLACHYDELVSKGLLTTIASNDTAEFF
>A0A3S5ERI8|diguanylate cyclase|EC 2.7.7.65|Fusobacterium varium|TrEMBL
MANDYWGHSFGDKLLLKITEKLKKYFRSTDIIGRFGGDEFLVFLQDFYSIEWLKEKLNGL
NEILTEDIEAEGKICRISVSIGAAVYPKMMASYEEMFEKADKELYIVKQKGRNGNSIYIY
EEEY
>A0A380KM11|diguanylate cyclase|EC 2.7.7.65|Streptococcus infantarius|TrEMBL
MTYLGALVAFNLMLKLAYDEIVINHKNPVELLISIIILGVSLLASYLNRRRHMLSYFILK
SSEYINMYALDLNYRFMAINRNDIRLMQEIFKFTPKIGDCPLRHLDAERSAELKANDDRA
LKGENFTSLDTIEYDGKTLYWQNMFSPIYNRRKKIIGAFSIVVDVTEQRKQELEMQRLAY
EDVLTQVHNRRYIELAFDECVLNKTEEITVIMSDLNKFKEANDIYGHTRGDQILIEYGEL
LTKVMPEDAVVARLGGDEFAVLLPGVTKQQADFLINLVKIEMMVKDMPVTASLDSYTDSY
QAHKTFVDFCACANERMYRDKNQKG
>A0A8G7SQI4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPSTIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGWLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G7HQ44|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATVAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHGLSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAKRLGELSFQEITYADDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0D0HLF9|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus ayderensis|TrEMBL
MFKQFIANSGILIAGFYLISKFFPSNIHQQSPVHMRLLAGAFCGLLSIVLMFFSIPLGHG
VISDLRHVPLVVVSYYGGMPSALAAGIIMGTGRFLFGNPFASIVSFFTSLAIAIGCGWIS
QRMKRHITITTFWLNVYSMCFVSLALFINMPDAHTYTQTLVVFWPISIVATYVAANICKD
IRQSKDMLQHYKQWATTDFLTGLYNVRQFHTLFGQHLEQAKEENSCLSLILFDIDRFKLI
NDTYGHDGGDVILRDLGELVRSLVSKDGIAFRNGGEEFSILLSSCEHEAVTFAEHIRTTI
ERHPFFVQQQTVHITISIGISVFPTLATNESELFKQADIALYEAKQQGRNRTIVYKKEYL
HET
>A0A3D3FXJ4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter radioresistens|TrEMBL
MNEQCITMLAEQWKDICGQYSATDLNYTAQFIQDNSFLLVDEFYKNMMQEKEASYFLSDE
IVQSRLKTTLNQWLLDCFNMPFKQNYEEVVQRQLVIGNVHARIGIPSWLIMRGIREIEKK
VFSLQASRTQQNIYAVTNYIVQSIGFASEIMCRSYEANIEINNDIKHTYRLFSAMQDVSI
QKDKQRSSLLDWENELMFKVFSDSASFNHLLLSKSEFGLWFIHKAAYAFSGTDQVQIIID
RIYEVDKLNLAVLESQDKANAIALIQRIREKNREIQHLVDQLFQVSEYIGSGNDSLTQLL
NRRYLNTIINREINFSRKNGSPLTLLAIDADHFKGINDKFGHAAGDLALQFLAEVLLECT
KGSDYAFRIGGEEFLLLLVDSDLSRAQSVAENIRMRIEETVIRSTMGVSFNFTVSVGAVL
YDGHPDYQRFLDAADSALYAAKNNGRNNVYMG
>A0A181Y7I2|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGKQGQFSQAILVDGRQKPFASWHNDGLARQDKVSDVIS
KWLFPEPTVQPILHQGKVIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINALMKDETVHGSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAILLRNVHTEAEVQALCSALSEQFIPPFNL
HNGHTVRLSLSIGYALTWEHASAENLQELADQNMYRMKHQRLQRTQK
>A0A6N3BST8|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MKLAGPHPDELRRLQSLRASGLLNSGKEERFDRLTRLARTLYDLPVASISLVGENTLHVK
SCVGLDVDTLPRDITFCAHTILQTDPLIVNDLQQDMRFHDNPLVTEAPFIRFYAGYPVQL
PDGATVGSFCLMDHKPRAFSGHEIQILSDLAAIVEDEFKVLDAATADELTGLFNRRGFLS
LAEYALLTARRRSEPASLVFIDLDRFKLINDTWGHEQGDKALTAIADVMKSTFRESDLIA
RQGGDEFIILLANTAQQAANKAMEQLSQNVAEYNQQAGNPWQLAFSWGCVEYDPHEHHSL
NDIVAVADRRMYQAKTSHGAERR
>A0A6N3DYL0|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MKLKNKLLRHLISAGVVVLTSSFLVYELVVSHRDMSEYMHYIVEKGEYAFLYDKYQNQLV
ISQIARKLDTLPSAEVAQQACDSVQTKGSVSGLNITEYTFPLLSGTLSANQSSCLAWVND
LPALQAFDTIIDHNRTHHGQETGPYKSDNKLRYFIDFKNKYVYFHTQVEIKNRALDNWNF
LHDGKLGITQTNLNSLLRGRTLMSSIYVDAVTGQNILSFLSPVYHHEGLKGVVMVDVSRK
DIEELLYTADRPLVWRYLDITLTDSDSTSEIIVHRSKTHLFSYAHYQHAVATNLQISLSL
DVMYFLLSSWKLFLFYLISTGVLLHLVRMHFRLYIDFFKENISDSLTGLYNRKILSSLLE
SRMQKLTEQGVNIVFMALDCDRLKYINDTFGHNEGDRAIVMLAQSISAAIRKSDYGIRLG
GDEFFLILIDYAEEDAKNITERIRQHLRTIDVNKRVNFSWGACSMAPGDSLADTMQIADA
RLYENKKQKKHVHPGRED
>A0A854PWT1|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. KAs 3-5|TrEMBL
MSSSSSDVPPAAATADAASGQACYLSASNAQAWEAVYQSVDANTRGQVAALVSDHAAQLV
DAFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVREQGDIDVLMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIAQRLRAGGLEGQAASVATQYVCNLFDLAIEQMSRAFMRD
INRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAASEFG
LWLQHKGAVLFESAPALRQIIDAVARLDDTVLPGMMQSASQAPESLPNQVRELQELVARI
KHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISLAQRQRSSFSVLLLDIDHFKA
INDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAALAAAEKLNA
EIRRHRFVIAESGALHVTASIGVATFDGHPDYAYLIDRADKALYKAKQAGRDRSVEA
>A0A8I0AYR3|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp|TrEMBL
MVFPNISDELMRMALRELEQASYHHEQWSEKLHGTLVCRAVPDKTDLEPDAHCLCRFGQW
YYHTGSIALRNHPGFQEIGAEHERMHRCAAHLLRSSRDGGVVARADYERFVGALKRMNLE
MSNLREELQRALFNLDPLTGAPSRIGMLTALREQQEYVRRSHACVVAMLDLDHFKSINDN
YGHMVGDTVLVEVARWIMAHLRPYDKIYRYGGEEFLICLPETDAATGYDILNRFIAGIAA
LPFAVEGKDGFRVTASVGLADLGAHMPVERSIERADRALYLAKGQGRNRVVSWDASMDEM
PAERERSA
>A0A8B6KRF1|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MSELDSLSTLYRDACVTYATLSIGYFALSKNSPFSYNGEVWKRIVFGLIAGLVSLYLNQD
QWVISGAYFYSFELIPIILVTFYGGWLSGLTALVINFTFTGWVTLDNVLITIVIIPLLFS
KVWEKKSSRIFYTTIILIAIYRMLTAVLLVPNTLFWTQIVVYQLISALCLAICYHALNFK
ERHIYAYFAMKDRANIDKLTQLNNRSSADYRLNSINHNRQACGLLILDLDHFKSVNDTYG
HDGGDILLTEVGKLLMTAVRDEDFVGRYGGEEFIIITHSHDPQAIKAVAERIRQRVESLD
VQLPDGRKLKATISIGASLFLPGMSMLKALKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRMVKDRRRRS
>A0A0J5XLG0|diguanylate cyclase|EC 2.7.7.65|Pectobacterium peruviense|TrEMBL
MNELLNVNEQRDHGESGYNQVITSEWTQLIATTSQQSFNLLRTLADQKASDFADEFYTYM
LKDQEASLFLSSQQVHDRLHGSMSKWIAAILTNTGDHLADLISHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVADDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSDFGLWFNHKGK
SSFSNIQGIRTIATIMTETDEYIRNYSHTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKSVNDTYGHAA
GDNILKRIAEILYESTRNSDYVFRYGGEEFLIVLIETPKVAAHTIIERLRKKIENHSIHL
QNGESVKMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A730ZMF4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 1,40:z4,z32:-|TrEMBL
MPHETLLENQGWFKKLARRLGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLVRLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAAQEREKK
>A0A448IYR5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MSDSEGVDDRLVGETRRLRVLIDSLPALIGYWDSDCRNVIANAAYVDYFGMTPGQIRGRH
IREVLGEQIYALNLPYIERVLRGQEQLFERTLVDQQGTTRYTQASYIPDIVDGEVLGFYA
QVTDVTRRVEAERARDDALRLFHISMEHAPIGKVVVDRSGVVLHANPAICRLLRCTQQDL
IGVDFRRFVHPDARATGDAQFAALLDGSATHLSSERQYLRADGTSVWLQRDFVLVPDAHG
DQDVAVAQFQDITARKEAEAELARLAVTDQLTGLFNRRALVDCVTRHHAATPDIPLGLIF
IDLDGFKLVNDTHGHAAGDAVLVAAAQRLAQLIEPPNTAYRLGGDEFVVVAPSAQGSTAL
PELCRTVVDALSGAYDTDTTPVTLAASVGYACEATDDVDALLRAADAEMYRHKARPR
>A0A8F7N2A0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas amygdali|TrEMBL
MMLFASSRQDRLKWTRPELMLIFGSSLSMFAILGIVASLLARERDDAAQTAARAAANIVQ
LIDADVMHNAELYDSSLQGMISAWQRPDLQDLSPELRQLVLFDRSTAASFKGDLVLLDNK
GAILADSLSVIPRNDNFSDRSYFKDHKADPSLGLHVSAPYKSRWGYKDWCISFSRRMSGP
NGEFTGMVSAAMRLVYFKHLFMSQNLGVGSSINLINTAGILIVRYPDLEGEDLIGKDYSH
SPNFQRILQEGDGSFAAMSTQLNARRLYTFSRVGNLPLVVVIGQSEDEVYAVWRRNAWLV
GSATSVLCLGILWLTWLLCRELRRRHRAEDALASLAATDGLTGLDNRRQLDEAMETEWAR
AQRSGKQLSLLMIDVDHFKAFNERHGHQGGDEALRLIAQTISFNIRRPGDRVARYGGEEF
VVVLPETDLPGAMMIAEQIRKAAESLPLFPGAQQPITVSIGVVSEMVRQGDKLEAFFGIA
DKALYQAKHKGRNRVEHRSSVAREMTDQL
>A0A8F7N299|diguanylate cyclase|EC 2.7.7.65|Pseudomonas amygdali|TrEMBL
MTAKRFRLRVLSFINGQLSAWPIAVLALMVGAALTIMLALADNELYQRQLRQRFDMLAAE
RFSRLQERLDRQVTRLDTLCRFFIFSHQVEQSEFDGFVAPLLIGTQAYAWNPRVTFAERA
AFEQQAREEGSAEYAIREMDENGTLKTAAVRNEYFPVRFIQTLSKIPTPSGFDIASEPVR
HVALERARLLKRIVATPRISLLALDPSDTYGILLVAPVFSIGEPPSELRGYVTAVISLAQ
LMSIGTAEQDNLAVTMLDLSSPTKPEQVYQSPVAAIRNHLYASSLLSLGDRDYLVEVRPT
EIFSQSNQSIMPGRVLWLGGLLSLMLSALLYSLISQRQRALQRVAQRTRELRQRGQQLRA
AHGQLRSVLDAATEVAIIATDLDGLITTFNVGAQKMLGYLQEEVLGRLRLMDLYQSAELE
ARASVLSKDRGHPVSASRLMFLDAVQDAHHPSQEWTLQRSDGSTLVVNMLVTAVRDDQGL
WTGYLAVCIDVTEHKRVNEALAEQGQLLKKLGSQVPGGIYQYHLAIDGSARFRYASAGMC
ELFEVDEAQLLGDSEAVLRRIQPPDLTRVKSSILVSAKHLTPWSEEYRVDLPRKGQRWLR
AASTPERLADGSVLWHGFVSDITDLKRVEQELRALSVTDVLTGAYNRRYFQDRMQAELKR
IDRHGGNLSIIMLDIDHFKRINDRFGHAAGDQVLKAISEKISQRLRSDDVFCRLGGEEFM
VICPGARGSQAYQLALSLREGLRNQVIEGVDQVVTASFGIASWRAGEGIDTMLLRADSGV
YAAKQAGRDRVEPEQI
>A0A446CAW6|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MPATLLEWSVPAAILLCSIGLCAARFAGFNTLRWGYALGCLGTGYAIMLVQASDLSPYKQ
AVEDAFILGGVILACRALLSRRRRQTSCHIDIAVLLASTAMVIVSVALFSSAKLETFFVQ
ACCALVIWRATFSFARQVATTSDKVLTAAFLFIALVLTGQCVLYISAPTPPLAMGEWRVS
VWGTLVQYTGLLGSIVLTFAVFIATSYDAIEKYRRQAHTDALTGLLNRQGLDSLLASDSG
SPFSNGATPTGVIMADIDNFKHINDVFGHAFGDMVLARFGALLRPDADARIFAARLGGEE
FLLLLPGADLESATAIAEEIRANFVAQRWAPHAPNSRFTASMGVTLEQAGEPFASALKRA
DDLLYAAKRRGRNCTVSGEATIDTVHNLSTFSDKVGRKKSCA
>A0A446C954|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MRYPHVPWLPLLFYPALPVAAAVALLLWREWPPALTLIVPFMPWAMALICAATCFMYQRS
QTLALMLCVLAATAAWPALGREAPWALGHAMAWWALVYAINALWSERSSMLVDTAARTGL
MALGAAAIALAGKDGVAGALGVLSVQGKLGHLSVPIEGLIALLATGLALTLLLLRYGRPQ
QAGQWLGFVCMAWALPRGAQHPVELALMSTAALTALCVSLAHEGFHMAFLDELTGLPGRR
ALNERLQRMGGRVYALAMADVDHFKAFNDTHGHDVGDQVLRMVAAQLRRVPGGGHAYRFG
GEEFTLVFPGKTAAECKPHLESVRRAIEAYQMRLRDKPARPKADQLGMRRRGGRDGRNAR
PLRVTVSMGVAERGDALRVPEAVIKAADQALYRAKDGGRNQVCLYSLRRRPGQA
>A0A8E2P518|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIINPVPIKIKIFIFLFSCISIIFLLLHENNGIYITQTTQITQITQITQISYSVFIIGLF
FINLMIFIFLLLYYVSNQRQSYLLILSFAFLSNTYYLLEVAIISLSPLGNDLSTIYQKSN
DIAIYYLFRQFSFISIIFLAVYSTNVKNKSVLEDKRNIIIVVLSILILFITPFVAKNLSS
DNIKYSLNIIQYSLNRHLSTWNIVYTKIISVFWLVLLISSCISIRNYSKIWLCIILISIV
SVCNNLILLYFIDKSHPAWYMTKFLELISMIYIISTLMYYVFRKLNHANHMAIHDPLTNT
YNRRYFIDSLKNISKHHDFSVIMLDIDNFKSINDKWGHHMGDQVIVMVTRIIKKSIRKED
ILGRLGGEEFGIIIKGNTQKLLLSIAERIRKNIEEQCSEKLLSHGPEKITVSIGCFTSKE
NNLSPSEMLVNADKALYQAKRTGKNKVIIHSK
>A0A8E2TB14|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X2IYK8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MPFYFRKECPLNSGYLSIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VSRENISDAMTGLYNHKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTFEVA
>A0A8E2P2K8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSV
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2N9MGJ0|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MGSRDQFDNMPGPGPVDVSGERPGAVEALRKSEARFRSLLELSSDWYWELDAQFRLTRFE
GRQLAQTRVEELELVGKCPWEHDNVVRESADFAGIREALNRHEPVRDVEYALRDGRGYLR
YMSATGEALFGADGRFVGYHGTLRDVTRRRRAEALVALEHAVTRSLSEAESSRKVLQAVM
RVVCESEQWEQAGYFRIEDAAGTSRLIVGWTGPSVRKESMDYYKGTIDTVVPPGGLVSSV
FAAGKPMWFADVHASQTTWRERLQRTGEHAAFGFPVWAEAKVIGVLIFSSSALREPDGPL
LRTVRVIGDQVGQFLQRRQAEQVLRESEARFRALTNLSSDWYWEIDAEFRFTRIEGRYVE
GGECLAGENVLGKRRWETGLELEHPRGWTAHRELLVRHRPFRDVIMYRTLPDGVRRYISV
SGEPILDGGKAFLGYRGVGRDVTERKLAENRIQYLAMHDSLTGLPNRVAFSELLHLAIQS
AQRRKRRLAVLFIDVDRFKLINDTLGHDAGDELLKSMAHNLKDCLRSSDVVARLGGDEFV
VLLPEVAEPAEVTTVARKILSETTKPISVSGKEYRVTASIGISVYPLDSDDEQSLMKHAD
IAMYQAKDEGKNNFQFYSKDIKSHSSERLAMESHLRLALERSEFHIHYQAKNDLRTGTIT
GVEALLRWQSPELGAVTPSQFIPLAEETGLILPIGKWVLETACAQNMIWQRQGLPPVCMA
VNLSPRQFADECLLGDIACALRETGMPPELLELEITESMVILNPERAMRLLTAIKDMGVR
LAIDDFGTGYSSLAQLKRFPIDTLKIDRSFIRDLPADMEDKAITEAIIAMGRKLNLIVVA
EGVETQEQESLLRELACDQMQGYLFSRPIAADRFAELLRRNASPTLAGVALRAGSS
>A0A2X2HNU9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MINNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGD
EFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQE
LADHNMYQAKHQRAEKLVR
>A0A1V5LJY0|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MPPALLLSSVSSRLERARFLKTLLRRDGLTSLLNHTSFMEQAQTVVAQRRRHTGFTAMIL
LDIDYFRSINERHGYPGGDKVLVALSLLLRKRLRQSDIIGRYAGDEFGIIAEGLDEAEAL
ALSGRLLSDFAAIQHSTLSHSGFYATCSAGISILDAKNMTVESWVQSASKALQQAKSAGR
NCAIAYHPEAISRQ
>A0A418VZH0|diguanylate cyclase|EC 2.7.7.65|Azospirillum cavernae|TrEMBL
MSDATSSQSATELLGVVLDEHLRWVGQWHRAAFFRDGVGGERPSAPAAFAAWCVAANRDD
LVHQPAVLKLATLHEQMHRQAKLALLKASGGDSPSEAEYEAVIARFEEFVLHLRRMERAF
GAAASGLDPLTGLRTRRGMMEALEREHNRFHRTGKPFCLALADIDKFKNINDTYGHDIGD
RVLGATAAVISRGVRSFDEAFRMGGEEFLVCLKETEMEEGYAVIDRLRLDLMESPVLLTD
GREIAVTASFGLVEVDDGASVDDLLIRADRALYQAKNAGRNRVIRHGVDRPAAPPAPTKP
ARPRA
>A0A730PRK3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 43:z4,z23:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGTLLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A7U7B050|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MGGKNPQRLEKWIKILGLGLALLVTLLTCLLIYYERTLIRDAAYVETRDQARLYKAYTEQ
TLGTLDQILTFMIELEQNPDLADAKRNIDAIMKQRKEISPIAINIAIADKTGIIQHRTFE
GSTTSSIAEREHFKAHRDGLIDGLFVTQAIPYLNDKTKFMFLLSRKLVDKEGQFAGVVSV
MVDCLDFSTTFSRQQMSQGGSMGLFHTDGGKLMVRVPYRAESIGQAPKPMVLFAQSDRRE
ENLIDVSPIDGIERLVGQVKLDNFPVIVSVTQNYSNVMAPWRLKAMIGAILWLLMMAAIF
FTVRVLTNRLKAQRLVQRQLEDTQIRAKIGGWTWEIASDRLIWNDQTYRIFGLTPGEPMW
KRAFFRRIHQDDLPRLERRLKDAIECGGNYQIEYRACHENGDWLQIASQGEIVRDAQGQV
VRLQGVLQDITDRFRTEQRLAELLELNQRIISASPLGIAVYRADGQCVLANLALARFAGT
TIDQLQQQNFLTLASWRESGMRDAALRVLDSGIAEEMEAHAMSTFGVEVWLSCRFARFTS
GDGFHLLMLAEDIGAKRKAEAELRLAASVYTNTIEGIVVTDKSGVILSVNPAFTEITGYT
AEEAIGQTPRILKSEHHDEQFYVQMWKTLAETGSWQGELWNRRKNGEAFLEWQSITAITD
DQGAPVRYVAVFNDVTELRMKNERIKHQAYHDALTGLPNRMLLQDRLDHAIDVARRDRTH
LALLFLDLDRFKTINDSLGHDVGDLLLQAVADRLRSCIRKSDTLARLGGDEFVLVLSYFS
NTAEVAHVAEKIIHELVQPLTLEGHQIHVTTSVGIALFPEDGLDAKALMKNADTAMYQAK
AAGRNAFRFFDTSMNSRALERLDLETHLRSAVERLEFELYFQPKVLLATGEPAGAEALIR
WRHPERGLVPPNDFIPLAEETGLIVPIGEWALREACRLTAIWTSNGLLNGHVAVNLSARQ
LQHLHLMETIDKALKASGADPRRIEIELTESVVMSNPGEAVAILSELRERGFSIAVDDFG
TGYSSLSYLKRLPISSLKIDRSFVKDLPGDADDAAIAKAILDLSRSLGLLTVAEGIETAE
QASYLAALGCQLAQGYYFAKPMPVDQFEEWLRARQKVDA
>A0A483WXS6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRVIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A8D6SXQ5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEVFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A7W5BFS5|diguanylate cyclase|EC 2.7.7.65|Massilia violacea|TrEMBL
MSDVFTAAAEQEQEPAVTAFKVRVLLVDDQLIIVEAVRRMLSDHPDIEFHHVTDPQQAFD
TALLLQPTVILQDLVLPEVDGFDLIRRYRAHDILRHIPVIVLSSHEDPKLKAHSFAMGAN
DYMVKLPDRLEVLARVRYHSAAHINRLQRDEAFRFLRESQQRLADANIALQKLAALDSLT
GIANRRRFDEVLQIEWQRAQRERQPLALLLCDVDFFKCYNDSFGHPAGDLCLKKTAAVLT
AHLKRAADLAARYGGEEFAIILPDTDAAGALTVAQACIAHLQGLGMANPGAQPLGVVTMS
VGVATMVPTPEHGPAELIAQADRALYAAKRSGRNCALDAASLTPA
>A0A4P0Y2Z4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RCYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A2L1BYF8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A377WN01|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGDNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVITHYSQALG
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQ
GREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADGRLYLAKQNGRNQVCFRSAA
>A0A3S4GES3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIAN
LPGGHKPLNFTHILADGSATPCPNLCRAGGAV
>A0A485QH45|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDINAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A7Z7T4N9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLVIVAVAVGCALVSPPVGTRHEILTNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEV
>A0A377W093|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWLITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGR
>A0A377WJ02|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAKYYRLAADGSLVNHADLLISLSKLRNIFWFSGAFFCSAYLFTLFQLLSTAGELDQTWY
QARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQ
LAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEE
FALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNSVTAEACVQRADE
AMYEAKNNGRNQVIVWHRQGG
>A0A486Q0Y3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIT
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A377W3V3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLI
DPHKDGRIVDANIAALRFIIIPMRKCAPNIPGK
>A0A5B9PDU3|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MAHSINLQTPQVATLNVCDFASFQSLQSAINSATDPVLLVASASELPEVLALLRDRDDVC
LQDDPESLKSFRQDRLARMKHLTRPGKDCVDPLTQVHNRQTFVHFLRDMAGMASIEHPVS
LLMCDVDHFKKTNDENGHAAGDEVLCELANCLQQATGDRGSVGRMGGDEFGIVSDCSNDE
AKTLAENLRLAADKIRVASGATTTLSIGIASAQQPQRGSELLERATKALYAAKSKGRNRW
FCIGDLETQSKVEGNDIEVAGLENMARVLVERVANVITSRSRKLLHDAREEALIDGLTGC
FNRRYLDRRLKAEFDERGDSPLSVAFLDLDYFGHVNKEHGWSTGDKLLIEVCELIRQQVR
KEDWLGRYGGEEFCIVMPTTNAVECEIVLNRIREKVASSDFRSARSEPVTMTVSIGATSA
CENDRDYSEMLERASEMALLAKRSGRNQVCVGK
>A0A2Z2P2Q0|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MIALSSKQTAVTPSDILSQQRLDTQLKQLEFNALLFRKLDLERLFECLLTEGQSFVKFDG
LQYLAADRGVDIMLGFSRQHRQRFELKLGEHSLGEVILMRSRAFTARDARDAERLAESLV
YPLDNALEHHKAIMKVTTDPATGLRNQLALDDMLPREIRLVRRVEQPLSVILLSVDYLDS
IASDHGEAVGKDAWLSVATTLSGRLRQSDLIFRSDDDNFCILLNQTDLEGALILAERLRQ
VVDHCVSFDNVQFVLTANAGVTELSEADDAVSVLARAGEALRVASELGPNQVRAIAAEVV
CENDDSKEF
>A0A8G1GSX1|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MNKLNPLRNEELRLSIFIAFIYFLVAIMSIAIFRVGSGIALIWFANAIGVAYLSQLDFSR
WLTPLALLLAAIALANGIMGTPLSQSLIFIPGNLTEIVLGGYLLRSQIRDTGVFFNVAGL
IRLIWLGVILPVLAGSLVSAVVFAALDDIAVMHVFVRWAEGAVIGSVSVLPAAYWISVNR
LSGLKQALLNAYLSVMLLLSLVIAIIVPLTLPFPYIYITVPLFYIAYQSGVAGTVLANML
VAIALCVLITFGLLLPPPTLYSWGNALFYLPVLATLIPPLLLAVAMDMNRSASIALQQSE
RRYRSLYQHTPVMMYSCDESGRILTVNDVWLNTMGYSYLEVIGHAATDFLEPESAQCQLN
EQFPRLFEVGSCQNVRQQLVSKNGELIDVLMSAALEQDRASGFNRFLVVQLDISERVRAQ
NLAYRDALTHLPNRLLFADRLTTACQQSARSGDGFALLFLDLDHFKEVNDLHGHEAGDLL
LIEVARRLQSLVRASDTVARLGGDEFVLLLRGLSPGVESEQVGGSILQCIAQPYQLDPTL
RVEISASIGFAYYPQDGLDEASLLRHADRAMYCAKNAGRNCFKISDAQTP
>A0A8G1LXU0|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MNSSAMPMVYFVAPNAEHFDDIQSQLSLFGFDCQVFTRNSAILAAMHTQPPFAVVVDELG
LSDANSKKCVPLISRLSKGPVIFLSNAHSIAEQIDLMRNGVTDFLPKPFNPQQLIDRLDS
LQEQARPDPFRVLIVDDSEAVARWTCGVLSDAGMLSKHIQNPLEVILLIERMKPDIILMD
VYMPECSGDEIAKIIRQNKQYDSIPIVFLSTETHRGKQLMARSMGGDDFLVKNMEPEELV
ASITITAERYRQLRRWMTRDSLTALLNHTNIIEELTREVARAHKECRQLSYAMVDIDHFK
LINDRHGHMVGDRVIKSLSRLLRGGMGKPNSVGRYGGEEFAVILSDQTMMRAAQKLDELR
QSFSQLTQISTDSGEFHSTVSIGVAQLQDGQTAQQLIDAADRALYQAKAAGRNQVGLAT
>D8G221|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MQKNDSPMYLPTLDQVIDRFPLAVAPNTPLIEVVTLMGQIHSSCPVEQDIPCVPLNPPTT
EVSQSLAAPIIGESRAGCVFVIEDSRQEISKPSILKGIFTERDLVQLIASGQKLRGTTVA
EVMSMPVVTLTECKDQDVFTALILLRQHQIRHLPILNTKGQLVGVVTPESIRKAMLQPAN
ILKMRSVDEVMALDVIQAPPTASVLSLAQLMAEHRVSCIVIAKEVEQESEEQSAEFPPNS
KGNIYPFPAKTHPPIPIGMVTERDIVQFQALELDLSQVEAQTVMSTPLFSLKPEDSLWVA
HQEMQQRYVRRLVVAGDRGELLGILTQTNLLRVLDPMEMSGIIDALHLAVEQRTSELKSA
IASLSLANTQLESEMATRERAEQRLRLLESCVVSANDAIVIMDGGFLDASDPTIVYVNEA
FTQMTGYRPEEIVGKTPNCLRGPASDLAQIAKIRRAFLRREPLRIELINYRKDGSIYWVE
LNSVPVNNEQGVLTHWVSVQRDVTDRKQMEQALFEEKELAQVTLQSIGDGVITTDAGGRI
YSLNPVAEKLTGWSTTEAKGLLLAKVLRIVNEITRAPMENITQTALLEDRIVDQTNNGIL
VAISGREFAIDHSVAPIHTSDGRIIGAVVVFRDVTQVRTQARQLSWQATHDALTGLVNRR
EFEYQLEQAILGAQNLKEEHILLYLDLDRFKIVNDTCGHIAGDELLRQVSDLFKSKIRKT
DILARLGGDEFAVLLYHCPPEKGLDAAESLLRSIQSFRFTWQGKTFSIGVSIGIAAINVD
ATSSSCILSAADVACYAAKDKGRNRVQVYQIGDRELAKQRGETQWAVRINQALEENWFSL
YCQPIVPLINVKGSPEHCEILLRLRDEKGQMVSPMAFIPAAERYNLMHSIDRWVIRTLFG
YLQDAPSFVFPKQENSKSNLPFSTLGKARRQNVNSLYAVNLSGASINDDQFIDFLHEQFT
TYRIPPEAICWEITETLAIANLSKAANFIRKLKDLGCCFALDDFGSGMSSFAYLKSLPVD
FVKIDGNFVKNIVDNPIDLAMVEAINRIGHVMGIQTIAEYVENEAVMEKLKELGVDYAQG
YYLGKPQPFHLIVADSEEEVLGEFPAKSLTFEGKLAC
>W6KLL1|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MEQPLHRRNIILVAAFSVVLLCMVGVVLIALGQNATVHKEWERGTAYREKVLAAFSMREA
VLERSYRLTFTSTLDDFFDRDEQYQLFKGIATKFLAARAVLDKWGMTDEERHALAHAEET
IRLAHPLVEAAMARIVDGVPPAEMRQEIKDATAGQTVVIDKLNSFVAVIERTAKAEGISL
QNEIGASQQRLLVLSLGAGILALLIGLWILRREVQIMREIRQHQQQLEQMSTTDVLTSLA
NRRHMDDVLQNEINRCKRYGECLSVILADMDHFKAVNDTFGHLVGDRVLKDLAGILQDSC
RDVDIVGRWGGEEFLIVCPGTTLAGAAATAEKLRTAIEDHEFKGVGHKTASFGVGTARGM
ESVDSLVHQADQALYAAKDQGRNRVELGGEIPEEDRRLRA
>A0A3M2RBF0|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MKEFLIQRYRPDPSGPAIHPTLLRVAVDGRITHADRHAEAMFGYDASELSRLSVQHILAS
RQDDPFAPAHRHRLADGQTVLVTFKHKEGFFFTASLGLRLETLPSNPETRAAISQIDSKK
VDSRLLSLAERSANFGFWELDVASNDVFWSEAMYRLLELRVSANLSPEQALFYCQSHQNR
VRALIRRCMRSGQAFSIELPIMTDKQRLVRATLTGRALKSGGRVHRIGGVLVNHSSAMHH
DEQKQQAQRLLEAIATATPDLVVAIDTNFNLLHFNSAWEQQFRTAFDLEPQLGDNLKSLL
KDFPNERRLMESLWQKAFERDHFVAEMPLFSDGASSSLFELHFQRIRNDNGEVFGAVRIG
KDISSRVLQNSGGDHRMRHDPITGLMNRRAFSVHLERAISHRHKRQLIDSLLFLDIDDFD
GFSKLADTGTCDRYLRELASTLNLRVRKRDALARLGGDTFALFIENCPESRARRIADEVR
EQIAQFQFEWQGTVLQTTVSGGLLVIDKDAPEQPDILLSQAADLCHTAKTSGRDRIHTAH
ALPTEKDSDSGSERRLQQLRQALDDEALVLEFQALKPVASVTWGDHIEILCRIPAGPDND
LLKPEHFLPVAERYDLAKMLDRQVIRQTLAWLSQHRLLVPRLKYCGFNLSLASVLDDTFT
DFMEQAVATTPFTAGCFCLEIRESHATRYPDEVAVLCDSLHQIGCRVALEGAGASVESYS
LAANLPVDIIKLDKRVMHQLESDPVQQIMVDALHRIAETTGKETVATFIENDETLRKVRS
LGIHFGQGFRLARPQPLEDLTPAVVDLSTGRIGG
>A0A385Y262|diguanylate cyclase|EC 2.7.7.65|Dickeya dianthicola|TrEMBL
MTLPVPHAYRQKTFRQALTRINTLGVVIAMVFSWLLITVVSMCFFKQYAEKNLQLLGYTL
SRNVEAAVVFRDVTAANETLNSLGLQGQFSSALLTDAKGKLLAQWSSGETATPDWLSHLA
SKWLFSGSVIQPITHRGQRIGYLEIRGADTPARNFVFFSLGSLTLCMLLASLLAIVISRR
LHRGLILSLHHIAEVVHDIRENRHFSRRVPTVKLAELDGFGRDLNSLLDEIECWQRQMQH
ENASLLRHSLRDPLTGLANRTAFLNALSKTLQDPQYQTNTVLLFMDGYRFKKINDTYGHG
AGDQVLLVVASRLMHCARKQDLPARLSGDEFALILVDVPDMQEAQQRVEMIRQVMLEPII
LPEGQEVVMSLSIGVAQALPSMTPEMLIELADKAMYQDKQRQRRHDFERVLRYFDDEATE
NQ
>A0A1C6H6V6|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MQSDLCREACELLQQLMESYVSGSPGMVMGMIKHLSPDILVIGTGKHELYENLAALLQGL
EKDQQEAEGIDFVIKNAWYQAKPLAEDICVVYGEFEACEAETEGKQVVINMDTRLTATVH
RDAGGQLIIDSLHHSTPYVYQQEGEYYPKTFADQAEAALRRSAALEKDVQLDALTELYNR
KYTEKHIGQLLGKGGPGGCLFLLDIDDFKMVNDTYGHQTGDTLLKQIAAVLLRCAGESGV
AGRVGGDEFMLFLPDILDERERTAIARQLIAQTGEVFVALELPHSCSIGGASAVGGTSTF
AEIYRRADDALYRAKAAGKGVYRSSEDRQIKSCIDTEI
>Q32FU2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MQHYFYYIHSKHITSCFIFVDDVLSCLQRLNNQHLPAVSWSCSVSDQIIARVSQSLAKEQ
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
KRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHPALHS
>A0A212LDH7|diguanylate cyclase|EC 2.7.7.65|uncultured Pleomorphomonas sp|TrEMBL
MKRLKTFSKKQPLPEEPSWKPRVLSLQAIVVAIVGLMLAALQLAVGVTETVRQLDGIRSE
AMYRATTGLDLLSAIPARNAVNGGDNADAKAVLESLHSIADIYTRNHPGETIRVEVGDGA
DGQPAATDGDSATWGDSDLSVRRAFVLDDGATPVSGSFSARVDLGGDYAVWRKTIRDRAQ
LAAFIVLSVLMLAVILMRVTVVSPLERLSRLTRRLAAGELVEVPEPADRAREICELSEAL
VVFRNNLAQKNALEAANVVALRKLEWTTGNLDMALRSMTQGLALFDAQHRLLLVNERFLE
IFDLSEQAFGAKLTAQDVEDLIAGQIAATHDATGHSVGGELFGRHLSRLFTQAEPVSGEE
TFGDWIISFTHVVTGEGGWVTTVEDVTERRAQEARLAYLSRFDALTGLPNRTQFNDRLAL
DLSWAADNGIKLAAIGLDLNKFKEINDQRGHSAGDAVLVAIGRRLDGAAQDGEFVGRIGG
DEYCALKKFRSQTEVAEFIGRLERCFNDPIRVEENDISVGVSIGVAIYPDDAVDAEQLFN
NADLAKYRAKRSVTQNVCFYEAEMDEASRERRAMARDLWDALDRDEFHLTYQVQKNIRSR
ETIGYEALIRWTHPTRGAVPPDAFIPIAEECGAILPIGRWVLKRACADAVAWSDDLRVAV
NLSPVQIANDDIVKLVHETLLETGLTPQRLELEITESTIIGDKAHALHVLRQLKALGITV
ALDDFGTGYSSLDTLNSFPFDKIKIDRSFLAEAEVKDDSRAIVKAVVALGRSLDVPVLAE
GVETAGQLSILEEEGCEEAQGFLFGRPARLTGDEVSATAERSA
>A0A4U9I0E6|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MQDLAFIVQDEFRIISQATTDALTGLCNRRSFTLIADEILRKSVRNNKTFCLIIIDLNDF
KLINDTYGHAEGNRALKDFSEILQNTASDNGFIARLGGDEFAVLIPEASKKEGETFMAQL
SESVKEYNCSHIEYSLCFSGGVAVFDKHKLNSVSLMMKEADRKMYLVKKSSG
>A0A514V7A9|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MCVQPDDIVRKEVFSARHRFHPGRVVNICFIAVLIVSTLLTWREAVVLEDAYAATQHTHL
ENVVNSLDRQLQFSVEKLLFFRNGMQDALETPLAAPVLHDTVSRFNDLRNKPFWQLAFDE
RRTLPLNGISDAFVQQTTSLIRDDERLEKEMSAAFEMGYLLRINAPAAHAKRIVYVSRAG
FYVSTDPIDTVRDIPTRYYQLVTSPWFTQQSERDNRSRSVRWLTLINEKIVNVSVPVDYQ
RDWYGVLAIDFTFQGLKKLLQDAVGDNGEGEFQLYDNSFTLLATSESVASHVNHFDERER
AQIASTLENDTVGEIRLGSRYVNWQHLDHFDGVLLRIHTLREGAHGDFGSITIALTLLWL
LFTAMLIGSWFVIRRMVSNMYRLQHSLQWQAWHDPLTRINNRGALFERAKALAKRCEQQH
QPYSVMQLDLDHFKSINDRYGHQAGDKVLTHAARLITSTIREADVAGRVGGEEFCVVLPG
AGPEEAMRIAERIRARINDREILVKKSQTARISVSIGVSSARESDNYDFEQLQSIADARL
YQAKQRGRNQVVGQDEKK
>A0A011QUQ0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MHSNSQRRHRRSAVMQRIAGLERALEQAQHLLHQDDLTPLLNRRGFRRACDRWAGNGPMA
MAACCVMIDLDGFKAINDRHGHPVGDAALVHFAATLRRHVRPADTIARLGGDEFALILMN
CSGDDVCLLLERLQQALAGSPLSVPGGALPLRFSAGVAELHAAESLGQVLERADAALLDA
KQLGKAMVRLSVSPARSAPAAMASAGDRQTASACLPIAIDEGENDG
>A0A485A6P4|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MVYDGLTSRWGMGFASLLINFSNIVFIVSLAQLLLWDKRRTDSMPGPINVLNLFCYCLLA
AFLSAAVGTLGSMDVERETFISLLADWFSEQFSTAVLILPFILTVTIPSTLSGFRWSQLL
PVMVLVLSIILGVAVGGAESITFPLPALIWCAIRYPLPLTCLLTFLTGIGEILLVANALI
HLSPDAHLQPWQLFSTRLGIAAMLISPVIVASSVDAINNLVKQLALRADFDFQTRVYSRS
GLSEALKRQPQSATQQLTVMLLDIDGFKRVNDSWGHECGDCVLAQFAQRVRDLVGEQGLV
ARIGGEGVCCRHVERNAAGRVSCWLRKFARAWRRKTFVWGPHKIKLTLSMGLECRPVGGG
RITELFNQLLMAADDYLINAKQAGRNRICTPNAGGESVIRKRNDNSACVKYKLKNIVMWS
ISWSDQ
>A0A485BEH8|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MEKTFWNDLKHMARHSRKLSFTMPILIGFTGILLSFLLIAVFVTTTQRQNFLEDYHHVNR
NFTHNLAVNYTESLLRGNDYILARATKFFAKNDKLNQAINIDPQSGLQELMQLQELMPTV
SSISLADTQGHYLRAPEVLENDNSRAFDPKSRPWFIKQAEASTFSHYTTPYLDFFTQHPT
ITLYKPVISPEGRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDTGAL
FKPYVRDDLMDKMTSAEGQLYDEKNGIWYYYYSFTNPDWFVIYRVDNTTLVDLTRYETDI
VLWGFALAAIVIILFGLYLRHASHTVLMNIINAIKTGDVNRAPRLEAMLSKAIESNKQRE
LIYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIV
LRNVAREGLQIFQPLQISLYRYGGEEFAVIFTGEHIANAPAILESWRLNIAQRTWREEGL
TVTFSAGLGEWNMEPLEQLVVSVDEALYKAKQQGKNRIVRA
>A0A4Y6KY61|diguanylate cyclase|EC 2.7.7.65|Azoarcus sp. DD4|TrEMBL
MPPPASPPPSETVEADWLKLFDSVSAELRTAVRDVVVRHRAAMADAFYVRMLADNDARPF
LSHQAVHERLRFSMQRWLETLFSCVDHAAFTAAMAMQRHVGEVHSRVDLPVNLVARGARV
LKGEIAHRLPDSGLDREALVDAVLYVDNLIDLAFEVMSSAYVASHERAARIDEAYRVFSY
GQNMSLERERQRASLLDWENRFLQAMMTGQSGDELPLISESAFGLWLQHKATAVFDGSAE
LPSIRAVMRRLDDDLIPLCRLQLEAMDERGESRRLIKAVQSELGQLKFLIGAMFERFVDL
ESGKDALTQLLNRRFLPAILTRETELARSHHKSFALLLIDVDHFKQINDVYGHDAGDRVL
QQIASLLLNTVRSGDFVFRYGGEEFLVLLVEVDAQHASRVAEKIRARVQHEHFLLPDSRQ
LQVTTSIGIALHDGHPDYQRLINHADDALYRAKAGGRNRCEFAAATSTA
>A0A379JPU9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MDQILSLLSETIPKAQTLEQLARPLLSLLNQFTGMESTYLTTIDTEQGVQRVEFARNAGA
MIIPEGLVVPWADTLCKRALEENRLYSDNVAECWGDSDAAKALGIKTYLSAPIRSQDGRV
LGTVCAASSAQVARPADVEPLLALLSGLLGYALERELLVAQLQAANSELGRLALTDPLTG
LANRRGIMRDLVQLFALAQRDSKYVLVAVIDLDGFKLINDCYGHQAGDQFLLGIATELKR
NLRASDMVGRIGGDEFIVIALGNALQRPAPAQELRDAAALMQARLSKATVGQYDLGNGLP
PYEYQGASVGVVAVMPDGTTAEEAIRLADNEMYQVKQQRKQQRS
>A0A379JX36|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MVTTVILGMLCVYLLCFSVMFLLISTRLNGKKMGMEVFALGNLLLGLAYILQLFGGPPDE
GLVSVINHTLTLSAPVVYVLGAMRFFERPTPVLRPLLTLMAGYTLLQLLVQWLLGTEARH
AMLAAACASLFLAMTVVVLYGRRTFARDLRVEMLVFAVLIGGICILNAMKFAVILNGGLA
ALDMGSGFQKVFYLYMSFLATVLPPCAVWLVLRRLTDELRNLAAHDPLTQLLNRRGLMDA
LDAHFRSRTAGPAYLLIVDIDHFKRINDTHGHKAGDRVLSHVAAVLKATARQGDLVCRLG
GEEFVVIALGTDSTGAQQLAERMRAAIEHNEVVGTGVKQPIRCTATLGASGAFTAAQDFD
AFLQLADAALYRGKTQGRNRVEWAGG
>A0A655ZW11|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MRLLQDGIDKSIVKDGMLVYHPVFSSEDDRSLLGVMVGVVRLSTYFEKLVQISVMEQDLD
MRVIDTGFDSEDSPVLYQSPMWRADDEPKIERKLVLPNRDWVLEFELHQPINHSEEWVLL
GLGLGGVIISLLLSYIMRMQLEEKQRLTDMIEERTAELRYLVEHDSLTNIYNRRFFSQHL
CKMLDEKQSFTLISFDIDRFKQINDSYGHLAGDYALTHVVDVVKKELVESDIFARFGGDE
FAILSSVTDETALYTYLERIRKVVEAEPVMLNAETPLTLTISIGASINCEYSEPEILQSV
DDQLYLSKSKGRNRVSIAQQCSKVESNYAFNSGRMFDFM
>A0A655PUX0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIRNSDHLRSLGIAPNDVVAFSYPLPQTNALLGLDYRTVPQQWQSIKKAREIKQTFVSGP
VDLVQGGRALVIREPIFYDPPKDTRYWGVLSVVMDWDSLLSATSIYSFGEHFQVAIRGLD
SRGSEGDVFFGEPRVFEHAFAQENVYFPYGSWRIAVAEKQDLLQQLSWYTRNAVRLLGYS
VLLVLMAGFGVIMRLYQVAEERALHDPLTHLPNRRYFIYTIEHYFENAKRSHSEGNFALL
NIDIGRFKSINDSHGHSAGDKVLVACAERIKSSLRVSDLVARIGGDEFLVLIPRIHREQD
VLKVSDNILKRISETPIVYDDKLIHVRVSIGYALYDQSFATPDEMFKLADERMYTAKRRQ
NPLYRF
>A0A4R5IZ16|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. L7L|TrEMBL
MWRRLLPQPRWLPRLAVMRPQRVVLACFGAVFLVTLVVAARELYLVRERVIGERQHALVL
RALGVDAILSAERRRLFFLRDFSEYLFALYANVGTADADIERAYAARNDDAWQLPLQRGD
APLIGVGPRSLAGLQGFARRDADLKADLMVGRTLSQLLGPGLRGDLIQGNALFISSNGFF
AIYPPQDPAKAVRLMQRFDSMDYYRGHMPARNPTRSIHWAPLYTEFEGSRVLTTISIPVY
AGSQFRGVIAVDVAQQRLHELLGAASEPGTVHYMVNVHGDVVSSSGSGFTDLRKWPEAIA
GDWSGHGVAELFARGSGMLGHNGDLLFFQRAGQSPWLVVDVLPLSSLALAMFSRLSGPLL
IVWLLLPLLLWVTMRVVTQLFDHYLALGEKLQELAQQDPLTGLANRRHFRASFGREARRQ
QRGGTALSVLLIDIDFFKKVNDRWGHASGDRVLGALAQALHGTLRGFDLPARLGGEEFAV
MLPQTGLADAVRIAERLREAIAGCAVAAEPEAEPESDPVLHAADAGTSGPERVIRFTISI
GVAESPADAPLALDALLAIADRRLYDAKTHGRNRVVSDDGLHAGEADISERST
>A0A200L6Q2|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A7Z1D688|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A7Z8FFV1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSV
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7Z8BEV1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIRSTRVSLGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMASMGTQKLKAQGFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A8G1GXK3|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MALNQLSPDDFDFFREFLDALPLQCFVKNAHGQIILSNTAYQNASTEAVVPLKVIELGVN
ETRRPLVSPTPFVQANEKIATHEETRWNSQLGRYQTDYVIQKTITDDAGQPLYIVGSILD
ISEQKQFQLQIDTELKLLEMQAADVPFMQLLTQFVHSFESNFPGVLCSILLLDDQGEHLL
HTIAPSLPEAYCQAIHGVAIGPNIGSCGTAAYTGQDTIVADIASDPLWRNFADLALSHDL
RSCWSIPILSTKGRVLGTFANYHRYPCSPSSKELQAIKRGAYLVGLVIEHELTENQLAQD
KMILQESVQHTQTILDNMADGVITIDITGRIESFNSAASRIFGYSPEEVLFKNVSMLMPE
PIAGQHDGYLLRHQATGNTNIVGVPREVEGLRKDGSLFPMRLSVSKILRAGQPIFIGLVS
DNTLDHQRREEIYRLAFFDALTGLPNRRLLMDRIKKAMLTSARSGLHGAVMFLDLDHFKH
LNDHYGHHMGDLLLQQVSARLQSCVRENDSVARLGGDEFVVLLETLSEQAEQAIEQAKTV
ANKILECLRLPYDLSGHTHVSTPSIGVALFLAEQISIDDLLKHADVAMYQAKAAGRNTAL
FYNSALQGVTQAH
>A0A7Z8FI41|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSIYRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEQQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>B5ZCI9|diguanylate cyclase|EC 2.7.7.65|Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5)|TrEMBL
MMSVAQVAVDAELRRAFTNVPDATRLLVHDVVERLTPALVAAFYDHFTSHPEGQTYLTDP
ETTERLRGTLMVWMAELFSAAPQHPQRMADSQRHIGRFHARSSIPIHLVSEGVSLVQRTI
IHALGHENLTHEELTDAVLYVTNVLTAATGVMTFTYWRQRERAASNDVAYRLFALNQDLS
REGEGQKAALLGWSYNVLRSLYVAKTPEDLQTMGLARSEFGLWVTYKVGLLFEGTDISAL
LTGQIAKVDNELLPAILEDMAAERDISPALAALHAGVTEILSSLEVLFHASRSSNDVEDP
LTRVLNRRFLPSIISYELRVAHQTGRPMSVLFLDIDHFKHINDTFGHAAGDSVLQAIARV
LEEASRLSDVIFRYGGEEFLVLMGDTDTEQMLIGAERLRQKIENTPIRLPDGNLHQITVS
IGAAQYAGHPDYEELLRAADAALYRAKRNGRNRIEVADAPHHTPAPSLEGAS
>A0A455V6B2|diguanylate cyclase|EC 2.7.7.65|Halomonas axialensis|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVARILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVC
>A0A5X0GAM7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Braenderup|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFRLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A378K245|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MLTNIERAKLQLIDETSDMVIITKADPLDAPNGPEVVWVNKAFEKISKYKANEIIGQTPR
ILQGKETNQNTLKMIREAMKAQTSINVELLNYTKDGTPYWINFSIVYLRDGQGNLCYLGA
IERDITAIKNLNFQLSEKAKTDPLTNVYNQENFFIAGNEAVKNFHQNQEAVGLLFFDVDD
FKGINDTQGHIYGDKILKKVAQESLKLVRKTDNVFRYGGDEFAIIFSGIDVKTLERKAQQ
LQKKLAKSHISVSIGGTISKQSDKSINTLLARADEALYYVKANKKGLFFIRE
>A0A173XTZ7|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MPEKLKSKETIVFENSNILEIDSLIYNFQSMVDNLSNMILEAEITNKKLEESRKLLFKQA
NYDYLTELPNRQYFIEHAKNTINEFSNNNLYNGKNGIAILFLDLDKFKVVNDTLGHSAGD
KLLQIIAKK
>A0A8E1WBT1|diguanylate cyclase|EC 2.7.7.65|Aminobacter lissarensis|TrEMBL
MTARILVVDDIPANVKLLEVRLLAEYFEVLTAFNGPDAIAACEDGKVDVVLLDVMMPGMD
GFEVCRRLKADPATAHIPVVMVTALDHVTDRVRGLDVGADDFLTKPVNDLQLITRVKSLV
RLKVLTDELRLRASTTHSIGVDELMARSDLLQGKLPKILLIDEQTSSAAHLCALLDGAAE
MQIAADPQSGLFNAAEGAYECIIVSTGFSAFDPLRLCSQLRSLDRTRSLPIVLLVNKEED
DLTVRGLELGINDYLVRPLDRQELIARLRTQVRRKRYNDELRQSVSQTIEMAVTDGLTGL
HNRRYLDSHLPRLVERAAARRRPLSLMITDLDRFKRINDTFGHDGGDEVLREFARRVKKS
VRGIDLACRFGGEEFVIVMPDTEGALAEIVAERIRSEIARTPFKVGGSEQGVSVTVSVGV
SALVMEGDTVAGLMKRADLALYDAKTRGRNRVVARAA
>A0A151Y3L9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter pragensis|TrEMBL
MNTESIAKLAKQWKLICDDYSVDILNDAVHFIQRHSEILVVEFYKNMMLEKEASYFLSDD
IVQNRLTKTLNQWLIESFNAPLQHKFEEVAAKQQMVGKVHARIGIPSWLIMRGIREIEKK
IFSLQAESQFAENYTISMISYIFQILGFSSEIMCRSYEVNIEKNNDIKHSYRLFSAMQDA
SVQKDKQRSSLLDWENELMFKVFSDTQRFTHPALSKSEFGLWFIHKAAYAFSGSEQVDEI
ISRIHEVDLLNHHVLECERKEQTIDLIQQMRSKNREIQHLIDQLFQVAEYIDSGNDALTQ
LLNRRYLDTIVSREINFSRKNHSPLSLLAIDADYFKRINDKHGHAAGDLALQFIGEVLLE
SVRGSDYAFRIGGEEFLLLLVDSDLSRAQEIAERIRKRVQETPIRSSLGSSFNFTVSIGC
ALYDGHPDYQRFLDTADAALYAAKNKGRNNVYLAKLSAE
>A0A7D8B5M7|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MIVNGLEKWLGVGRADSEFRESSFIFISLTVLTLILTFFVCYNVFVIPSRLLAAIEAIGV
LFCLFSYYFLWQSRDPRVAAIILVSVMTSISLLFILGTGNDEFALAFCFLTPVIAIFILG
YKLGSLFSLANFIFVAYICITYMDNWSPVYFDTISFVHLTTIYFFLFSVSYFYDAGRRRT
MVLLEESNRQLQALSNTDGLTNISNRRFMEKLLLDSQVGQWVAIIDIDDFKQVNDVYGHE
VGDKVLVSIANILKVSVQGIGHVGRWGGEEFLVLFTDATEDVIESHIHQCQKSITDYDFG
IGRSVTISCGIAPHLDSFNTSTFSHADEALYRAKTSGKNCFRFSVAHKFTENPIQYQ
>A0A1E3KV21|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MTWSHWEITPFITSVFFILGVLTLFWVSQNWIINFFNTHHWRVDQSLITDWYGLIYMMLF
VFGMQTAVVGQNDAWIFMNFQLIGLTFCGYFLNVRVRYYYLYPLVFIFMGFNHSLYYWES
WGHAVTLILFFTALGRLRKHVPLQTKQGQVALYLVTCAGFGAVLWWFMKLKFNLSWATYW
QEWTYLLVFASLLYIYASMLSANAHLKQNLVAFANHDALTKIENFAAYKTAINYQVTSSR
KNGSQLTMLMFDIDHFKQVNDTYGHLAGDKILQHVAQVATIVFHANNPQISLYRTGGEEF
NVIFPNYDLTEALAVAEQLFAAINHIAVPVNDHQIQLSISIGLSELATDDQSPTAFYQRV
DANLYHSKKHGRMQITAK
>A0A8E6JBG3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>E3G208|diguanylate cyclase|EC 2.7.7.65|Enterobacter lignolyticus (strain SCF1)|TrEMBL
MSHVVKVDSLQWLNTLSWRNNPVRVVSLCFFVVLVFSTLLAWREVVVLEEAYISSQRNSL
ENVANKMDAQLQANLDGLKFYRNGMQAALQTPLAFSGLRGAAEAFMQRRQQPQWSVALDN
RRTLPVYGVSDDFIAQSALLSRDNPRLSNELTATLEVGYLLRLSTSVRRVAQRVLYVSRA
GFFLTNPSITDPKDTIEQYYALVTSPWFTSQTQRNNPGRGFRWQPHAPDSNVQSVAVSLP
VDYDHYWYGVLAMEFSLPQIKRYLVVASEGEEEGEYRLYDRRMNQITSLLTDGVIATSLT
DPDKAQIAHAFEHDTRGGLRLDTRYISWQKLQNFDGVLIRVHHLQEGLRGEYGSISMALG
VLWILFTSMLILAWVVIHRMVNNMTALQKSLQWQAWYDGLTRLFNRGTLFERANTAMKSC
REQQKPIAVIQMDLDCFKSINDRFGHQAGDRVLAHTAGLISSRIGSADLAGRVGGEEFCI
VLPGATKEAACLTAERIRERINSRELLLGKGVMLRISASFGVSGSDESGQYDVEFLQSVA
DKRLYQAKQDGRNRVCCSEPPPAE
>A0A5P9IWE0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MLHLPTLIVVSTLLNAFIGVFLLLVFYQRAQRSFLYWGLSCLVFSLAEISATLRVFIDLP
VLTHYSAQLLMITAPLLVLRGILWYCSSKHHNPLSIYFILGFSALLLALLHHQPLWGQIY
TSMAIATLFFAAAAAVRTTTKGNIYAATLLILVTLHALVMLVQTGLLLTNLLHWEQSLLP
WTKQLVLAVHLLLTTCTALVFPMLFFIRSEAKLTNLANFDPLTNLYNRRAFFYEGEKRLA
QCIAKQQPLAVMMIDLDYFKKVNDQFGHDGGDAALQWVSQRIREQLREDDLAARIGGEEF
AVILANTHQCTALKVGDRLRKAIAEGSFYWHHQRLPLSISIGVTCRESGHFDIKKMLIEA
DKGLYEAKSRGRNCLVETHHSDTTTASTG
>A0A807E3W2|diguanylate cyclase|EC 2.7.7.65|Bordetella bronchiseptica|TrEMBL
MKPSPEILALRWKETCAHYSPHEWVAARNVVTAHKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPGGEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDLDASLSAAQAAAACRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SNQLQHIDQLLADAQQTQPPPDQRLAILHGVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGIPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGAQALNVAEALRRRVQEKATVLPDGGELRLTLSIG
VAAHDGHPDYQRLLKRADQALYAAKSGGRNRCVLAHAGPAEASPRPDDMARSGRH
>A0A173T5Q6|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MIKGNVKIDRKNLISILQSCLVLILVILVALMMVEIGNLKGTARVINYAGLVRGDTQRAV
KLEITGTRNDELIAYLDDILSDLTSGEGHYELVKLKDAAYQERLDSQRAYWERLKAEVAA
ARQRGYENTQIVAMSETYFEMADETVSAAEHYSEKIAMKIRTIEILSALDMLCLVILIML
QTAMALKMARKNQLLEQKAYIDIHTGLPNKGSCEELLNNREILREPTACVIFDLNNLKTV
NDTRGHSAGDQLILSFARLLRRVIPEKHFVGRYGGDEFMAVIYHTDRQEVEGILDSLRRE
VDAANRDGNQLPLSYAYGWAISADYEDCIMQTLLDKADYCMYENKRAYYATHDRRAPRS
>A0A6N2XFF7|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MDKDLSPTPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQRNLELTAATMT
HSLEAALVFADDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNALENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRAVRSIK
>A0A517X598|diguanylate cyclase|EC 2.7.7.65|Gimesia maris|TrEMBL
MGSSKILRQLISLSEDFEEYSLESDTGDLIDQVISRKHLRKLLSALQARDASTLCHSRRV
AFLAKGIATNLGWEGIHLKRLEVAALLHDIGKIGVPDHIIFKPGKLTSDEIELMSHYHNI
GLDVLQACRTDHEVLTILSQTRYHFSGATNGYQFIGSEVNQGARILAIADAYDSLATDQV
YRTGKKHEEIMSILMEAAGTQFDGNIVCALSRWEQNEKQAFHDALQEVNRLFQPKDFTER
EAIEANLISNIFSYLFQIESLYDGFYIVNADFQFVVLSPGLEKLADLRAIDVLGESWTSG
SLPLTNKEGTNLTSAECSMNRVIANGKPMTTEFMLERPGGRLINIEVQSVPMFGDDGRLI
GVTEIFRDLSRSLKRPKEYNDLKLAASLDALTSVANRGELETQLAIMLSRIQKEQNPEPL
SLIFIDADHFKSINDSYGHSTGDEVLVELARLFQHETYSGELVGRYGGEEFVILCPETAL
EHAVKKAERLRLAVSNLKMENQSNIRVTASFGVSQYEPGDSLESLFHRADSALYQAKETG
RNKVRALTCEQMKSGEIIPDEVPEATAAEGMKFESTFNALISSDFIVYKLGGFVNDNHAR
LTEVSTNRAVMRLGKAGLLPFWGKTDDRKPVEIEVVFGSSTKKSNSNRRQTSSQVEIATR
ITPMGWIKQPEVFQQRAGRVFRLLKDYFAAE
>A0A4V1BPC9|diguanylate cyclase|EC 2.7.7.65|Citrobacter tructae|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSFGSIGASLLFFPTATLNFVYTAINIIEAVAGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPALLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARIPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVELNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHAVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFTWEGRLHRIGASAGITLIDDKNHVATEVMSQADIACYAAKNSGRGRV
CVYEPQQGQAHAARGLLSPDEQRKVITHNPILMVARGVASPRIPETFSFWLLSLRLWNSE
GEVIEEQAFRAGLLDPALNHALDRRVLNEFFQHSASAVASKGLSIALPLSAAGLLNPVLV
DELLELVESSPLPPRLLHLSVPVEVIKTNPTQAVSAIHRLRQAGCRIILGNVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQGHAQRLDIKTIAGPVQIPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A5C5WX79|diguanylate cyclase|EC 2.7.7.65|Rubripirellula amarantea|TrEMBL
MGASLILSAQWLGFIPDSAALQMRARRDLSEIVAINATVHIRRQNWNDLKASLQATVDRH
PDLLSIGVRSDMGTLRTDTGHHAEIWPQDIPPDVVFDGKLNVHESVDDSESEVVTATVPI
MLNHRPWGRVEYCYRRAAKTYVGGVLINPMVRLLSYFVVFGIVAYTIFVARVMGVFSSTQ
VVPDRVRQALDTLAEGLLVLDETGKIVLANKAFTTIVGLSAEELERRPASDLAWVGESND
DALPWTMAMLNGELQSERMLRYTFDSDSERILSVNAAPLGKGKSGRGVLATFRDVTHVEE
HRLELERMLDLLERSRDEITRKNDELNILATQDSLTGCLNRRAFFEIFDGMWSEAKRDAK
SLSCIMIDVDHFKSVNDTYGHHTGDEVLRAVSAAVREMFSSNGLVCRYGGEEFCIVLPGY
DVEAAFAQAEKARGAIGQIRLDDPAELRLTASLGVSELRFEAKDTQDLINQADACLYVAK
REGRNRSIVFNKSMIVTDESAENAAAEALAVANSERVEIPYKAVTALMSALSFRDTKTAE
HSRRVADLCARASEGLMNPSERYVLEVAGLLHDIGKIGVPDEILFKPGPLTPEEWEVMGR
HDNIGVDIVFGAFDCPPLTAIMANHHAFYNGAGRERDLPSGENIPVGARLLSIADTYDAI
VSDRPYRKGKSHEEAIAEIRRCAGTQFDPTLVEHFVSKIEAAIPTLATGAIAIQKFAAIK
IGAQIEKLANAIDQQDAAQINHLFNDIRVLAENSGLVSIAEATPVSSDESDETKITRELL
RDARDLVDTCRSAQIDFLRKSFEHQNEAEADA
>A0A7Z1EKA1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A658Z0S1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGIAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQHVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDNLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>A0A7U9G4Y6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA271|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLYQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A380AWS0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGHLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A658Y0N3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSG
TDITEERRTQERLRILANTDSITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKV
NDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTR
LRLPFRISLIEVYTSCSVGISLSPEHGSDSATIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIENHLAWRSAQSGSTSTLAVT
>A0A0D8HZW9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MTRMGRVTRLLVVFVVVLLAALIGILTRPPGLLATFWCANALLLGMMVRWPILIEWPTWI
AAAVAYVSADLLTGNTLSMAIQLNGANLVGVTVGVLLLDYLKRTPFRLVDSTSLMWMVVV
AGLSACATAATAGLMDWVFRGESFADTLVHWGSTEFMAYLLVLPLILSMTIPSSIAEIRS
KTTVRAVLAMTVPLLATAACMPIALSIEGPIALLLPIPALLWCATRISVPSTALVSAVWS
VWSLMMADAGRLALGEQSGANVNEAVITSIAVTLVALGPIAVACATQERRAAERELFRAV
EYDSLTGVLSRGPFLRQAEERLQQATQTALPIGLLMLDLDHFKAVNDTYGHMVGDSVLAD
FGARMAERVSDTDLVGRLGGEEFAVLLTGSSFARATEVAEEIRHAQVHDSARSGHDSTVS
IGLAWTDDATPTLASLMVAADAALYEAKHAGRNVVKAQNVSDIVSGVVSERITRTA
>A0A1H8DL71|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MTLDYNSLLMALAVSATCLAVTLLGSWFARRSETFLLSCTLGLVLIVSGIVAYGLYVDNP
VVAFAVVSFVLFHAGFPIVWGAGYQFRAGRLPRVAVVACALAAMLVSIPPLLIGYDGLAF
IADNAAIAAMLVSTAYQYWRARSEAPAPLTGITALYCLTAISFVLCAAVLIADGKMVLGV
APSNWAEDLSLAICIASMTGIGALSLALHQWRLAARHRLDAMTDPLTGLVNRRALFDRYG
QGLMGPATAVLIFDLDHFKSINDTFGHAGGDRVLKVFAAELAANCRTGDTAARLGGEEFA
LVLKEIMPGRAEMVAERIRKAFAGREIYLDDETLACTVSVGVAPGRSTPMDFDAMLSAAD
KALYAAKRAGRNRIELASHLHAVPAGAARTCS
>A0A8H1AI38|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4694|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6N3GMB6|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MRSALTAFRLFQPDTPLRNASAIFILTTLFYFVGAELRLVEALSLFWPLNGVMAGIFARY
VFLHRLHYYAVCYVAMLMYDAVTTNWGMASVVINLSNMIFIVVVAVLVQRDRRLMKKTPD
PLNALRLFNYCLIAALLCALLGAFGSVGIDSHTFWPLFADWFSEQFSTGVLVVPCILTLG
LPVRELRVNLEKLLPIIALVVSVAASVVIGGAGSLAFPLPALIWCAVRYSLPATCLLTFI
TGAIEIILVANSIINIAVATPLSTPMMFSARLGIATMAICPVMVSVSMAAINSLIRQVSL
RADYDFLTHVYSRSGLYEALKREETHRHPRFLTVMLLDIDYFKSINDNYGHECGDRVLAS
FARQVQQVVGEDGMVARMGGEEFAVVVNSGDEQHGYALAERIRSTVASHPFTWRQQTLYL
TVSIGLGSGKAESWQLTEVFNKLMAEADDHLYRSKKAGRNRTSARLADEQLAASAGSETE
LR
>A0A6N3FZ44|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MQMQTSSAWESFYVMSDIILARVSETLVTEQSLESLVRQLLEMLEIVTDMESTYLTKVDI
QARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTIFSNDVPERWPECEAAKALGI
TTYMSIPVHLADGSLYGTLCATSTAKKPLSERGEQMLKLFAGLIGQYIQKESLVNQLREA
NAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNAIIAFIDLDDFKLINDRYGHE
AGDQFLIEVGKRLTAEKQQDDIIGRLGGDEFLVASLSHVDNEEHMNQLKARFSARISGEY
WLGNINLIYPGASLGVIEVDPDVTDPDSALRAADVAMYQDKKGKSKTRFLAMD
>E3HJ50|diguanylate cyclase|EC 2.7.7.65|Achromobacter xylosoxidans (strain A8)|TrEMBL
MPTRMPSLPGDAVLDPILAELSTTLPEAKSVEQLTRPLLDMLGAVTGLESTYLTSIDLKA
DLQHIRYARNAGALQIPEGLSVPWDDTLCKRALDEGRLCTSDVSSCWPDSDAARQLGIQT
YLSAPVRRDDGVLFGTLCAASATQRQIEPRAELVLKLFSSVIARFLEREMLMEQLHAANV
QLMSYALTDTLTGLPNRRALYEALDRLQARAVREGGSVLVGVVDLDGFKGINDVYGHQQG
DVFLQEVSRRIAAALRGSDMLGRLGGDEFVLIGPGPALAAGDGPHGVHAPRGEAEEAARS
LEERATAATVGRYQLGEDAVPYEGASVGVVALDPRGLDAEAAVRLADARMYEVKRARKTA
RVIH
>A0A1X3I7D9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M056|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A011RD79|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MFKHDESSPLQSSRHASRRPHRLPDLANLPLPMRGHLSLPTANGRVHHPHIRRVEAPVPA
PGALQLLVAEARIAELESALSEARQAAFTDALTGALNRRGFDEAYKRELARSRRNGSQLA
IALIDVDDFKRLNDTLGHHMGDETLVHLVKSLRAALRPSDILCRFGGEEFVLLLPETALD
EAVAAISRFQRQFAASAVPGCALAVTFSAGVVVRQNSESLEDVILRADAATYAAKRAGKN
CVISG
>A0A446ZH42|diguanylate cyclase|EC 2.7.7.65|Acinetobacter calcoaceticus|TrEMBL
MSFSHYTLRQTEYLKKHMETLDSSIFDLSPIPMWIEDFSEVKQQFDLWRNQGIENLHEFL
SQNKNLIIECAHKIKIVRVNQKTLELFEAKTHEELYSNLNLIFKKEMFESHIHELEELWK
GKTHFSSTTVNYTLSGKRIDVQLRGSILPGSESTFERVLITTEDITPYQNALREEEKNRR
LAESMFIYSPTSLWVEDFSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVN
QATLDLFKAPDKTTLLRNTHKIFAQEMIETFREQLIELWQGNIHHKREAINYALDGQIRN
VLLQFTVFPGYEETWGLVQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRL
NRSIIRPVSSIFLDMNGLKETNDQFGHDIGDGLLRRVGNILNQTIINTPYTASRIGGDEF
VILMPGADEANVLIMLQTIQELFNIDNQYYSSHPVSIAIGHATTQANEQIEDMLKRADHH
MYQKKKSYYQEILFNQ
>A0A518BGC1|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla133|TrEMBL
MIPLERAFAERDGNVLLRAALHDSPDAVVVADDDRRVVGLNEAAEQLFGWRLADVVGRTL
DVFHAEPAHGRDLEESSDPGTAGRGDRRLRRSGGEVFIGETAETPICDDGGRSIGMLVTI
RDVTNDRRTLRAMSELYSVISSRELCYQDKVERILEIGAATFGTSSGMVCRVDGEAVTVC
HTYDGEQIYQPGQRLSAARSFCGEVLRRNTAVACHHVGASELRHQPFYDDGLVESGIGAP
LNVDGERFGTVSFLSPEPRAWPFSEQDVDFVRLLSEWIGNEIARERDLQALRAAHERLRA
LASTDELTGVGSRRHFMDLARHDWERTRRNGRPLSMLVVDLDHFRKVNETHGHAAGDELL
AAVAGACRRVLRAADVFARIGGEEFAVLLPEAGEERALEVAERLRAAIGEVTVDGADAGA
SVTASIGAVTAGEADSDVRALMARADEALERAKERGRNRVETI
>A0A380XGF5|diguanylate cyclase|EC 2.7.7.65|Cytobacillus firmus|TrEMBL
MKKPIRLRIQWLILGLLAFAMLGTYAGSVISSVVVSRNNLEINYLIENQYYAQKLAAVTD
SLFVNMIKNLTMEARNEDLMTNDSRKIHKELDFILQSTTYFNSTFFADKTGRIVASAPDM
ALKGTKLTSVGAKKSLEKKVPIISKPYVGVTGKLILLISVPVFDESGSYEGFLAGTIYLH
EDNSLIQVLGQHPKHENNSYVYVVDSEGNIIYHPDKNRINDNVKENKVVQYVLEGRNGNL
EVTNTKGIAMLAGYASAASTSKWGIVSQTPKESVMEPTFEMARQVSLIAILFMLFVFALS
LIMLKKIVNPIRNLALYAKQMTTEPSRPVPQIPNWYFELKELKRAILIAVDFYQTKLTNA
ESESNLDPLTGFYNRRFLEKKISELDRYSIILFDIDHFKAVNDQFGHQAGDEVLKFLSEL
VKGETRASDLCFRIGGEEFLIILPETDIHITESVAERIRKITEYTLSPSGKPVTVSMGIS
SYPAAADSFSELMNKTDQALYKAKQEGRNRVVTAV
>A0A518BKV3|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla133|TrEMBL
MTSPLLTNREPAPKGDLLRRLGLAVVELLGIFVTDISLPTSVAFGAFYAVPLLFCFHRAR
RKEVLVLAAASSILAPLGAFIGSDGWATPELGVVISASTAVFAIWLTAGLVLNRLTEEEQ
LIATRELNEIALGATEEGVVVTDAQGIVTWLNRAAEGMLGWRRVEAEGRSLSDVYRRVDD
ETVTRAPELPVDVIIARTRSGARLPVEETTGVIRDLQGAPLGHVVVLRDASKRESLEREL
RQMAFRDRLTGLPNRTLLAERLALELDHAARDQRMLAVLFIDLDHFKEVNDTLGHQAGDD
LLRGVAARLQECLRAADTVARLAGDEFVILTPGIHNRQDATLVAQKVCAALSEPFHLGSH
ERTVLPSIGIAVFPEHGVDGDVLLKQADGAMYLAKHEGGGRFAFADGIADSESGSGPGSG
RSKSHSD
>A0A128F994|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MPDFKDILDIHPNPCVIHINFVPKYANNAFAKFSGMASAEDVLSLPSIRVLFEEEHWPEA
QRRYNHAMETGIPTPPEVINHTDLKGNPMIAEISDKVIDWYGEKAMCTFVSVVTDQIRRE
RTLRDMANRDDLTNLYNRRYLLDLFSERHAAQQRRQYLAMADIDHFKRINDTFGHPVGDI
VLRRFAQEVEDFTAPDEYAFRLGGEEFALLIWADNQAEATLRLEQLRQEVEDREVRVSHP
NSQPLSISCTISIGATALDATEDFLSASLRADEALYTAKKTGRNRVINYDEPSDDKS
>A0A411T082|diguanylate cyclase|EC 2.7.7.65|Alcaligenes faecalis|TrEMBL
MSQPNIEEAAQDWHGLLQKVPPAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHD
QVHKRLHRSLRSWLVQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFLFESSDISSEQAWECFRYVQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNLIDTQLMPAFEKGDAKGQVLLLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDYFKRVNDTHGHDAGDRVLRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMAITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYV
>B2U1J0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFDH
QLRNTEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGEE
FIIIVKVR
>A0A238DRJ2|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MDDISQRTPNQSRSAFWSVVSMGFIVWLTAALGYGFQSWRAVADQAWLQLDATSALAKSV
TQQNLQQYLRGFDFLNHHLKADAPALEHADPQAIFALLRQFRRMYPDFDAIDVILPDGRV
VADASKQDLRAVQPVTQAYLHKLRQRPDVHTAFPKAAASAAGLAVVRLGFAQRSASGAIA
YDLVADIDLHRQITSWLRPELAADMARHLQMGLVTRQGDLLGLWPEPTGPTIYAARLASW
FRLHALPPSPRHPLVATPEHVVGPIHVDDSGTDRMAWSVLVPLKGAPLETFVSVPRATVR
DAWWQQVRLPLLEWTLLGVLFALMALRLNKLQRLERQRTLRLEQAERTARQSSLFYAALA
QTTQALMGHKAGDVSATFEDLATSLCALLQARLVCVGRLPLGQIWVDMTACAGPASNFAQ
NLRISTDSHRPEGRGPASQAITTGKPQHATIEAPEFAPWRRRAQAFGIAGVLSAAARTQD
GEAVLVCAYYASESVIGPEAAQVFQRMADAFAECIDRQANIVKLERIERYRSARRKIQRG
LLEATDAAGVYRVLAQTLVAETGADVVEVFAPEGDMIKRRVIAGPLEQALSHLTDVPLQA
LARGEGAYMRARVWNARAPVLIQTPSADPKLSPRWREQPLCAMGLLAGWPILAVDSGEPM
GVVILVARDPHAIDEELQHLVTNILESAAIALRQVRDRQRIETLALTDALTGLPNRRSIL
EHIPQALARAQNRRRQVAIGILDLDDFKSINDTWGHAAGDALLCDVSRRLQTTLRGADAI
ARLGGDEFVVVLEELSGPDDLSTVLDRLEAELTAPYTLPGGQSTPMRISLGLTVYPSDDA
TPDILLGHADEALYDVKARKGSRQRGWQLWSRTPRPTTISTAAHDGPAHDSPHLENDTTC
KAS
>A0A1A8T967|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MHDINELIENVRHNEQIALKFFEIERCILSIGRCDQFVSTLTREVQKQFNVPYVWVNLIN
EAPLSHLMEALEKSSDLRDRVLFTRRRAMIDIIKASSRTVLVNDDLSQCDEIIPSVYRDI
ISSVAISPLTIDGELVGLFCQADSDSTRYDAATKDTFLLDQLAIKISICLSNVTAREKLE
YLATRDPLTGLLNRRQLELMLDREFARSQQQKRDLTVVFIDCDGFKSINDTLGHNCGDEV
LEYIAKRLLKYVHKQGLAFRFAGDEFVFVTPGKSYDDALLIAESIHDYLQSNPLRYKSNH
VPITISYGGASVMEDMPTNYKHLLKIADERLYSYKNNRKRSVPTKVFKFLNRMR
>A0A1A8TTX6|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MFKWFNASITRKVSSLSFVLLSFLFVVILYSVLKLQKINYEMREVAQIDVPLSDVISQIE
LIQLKQHLLMETIRQQKQALFDHPSLKKKALLGFNDYNRSLSEQLVKAMQVIQNGLKRGG
VRIQVADHQTLIKQIRSLHIEREAFDHLVNQFFLHGDTDFSLHWSNIEKHCKKLDTQSGM
LLKNIDQLTLKASLYTERQEQELMIVNAILGIAALFIGTYLTLYIVQSVRSRVGSIRWKI
ESLHRTLGEDSDEVGANSYQDLDEFSVLEADLNILTNRLSKERSNRYEVERQLIELATRD
KLTGAYNRHKWDELLKEELALANRGGRFSLALIDVDYFKKINDMHGHGVGDKVLQFLVTE
LNKLIRETDMLFRIGGEEFAILLKNTGLDEAGKLAEALRLKVETFNTPSLPRFTISLGVT
GSQESDDQVSILKRVDMLLYKAKGAGRNQVKIG
>A0A083ZV18|diguanylate cyclase|EC 2.7.7.65|Serratia sp. DD3|TrEMBL
MAYTPLIIDSKFAGLSFAKRTYLPRIVGLGLGLFGLSATIYPLHSSPFIWGLLIIYTLIW
PHIAYQWSIHSEKPLVTETRNLLIDSLLAGVWIAVMGFSALPTIVFLAMMGMNNTAAGSY
SLFLKGVVAQIVGAILTSALLGFPFTPQTTPLQLYFYLPVLFIYPVLFGLVTYRAAKHLV
EKKREVVRISMRDGLTGVYNRRHWEHLLRNQFDSCRRYNHTATLILIDIDRFKAINDTFG
HALGDEALIVLAEELVLGLRTMDIVGRYGGDEFGALLPNTPPEQASQALSRIQEHLREVT
FRDAPDLKLYISAGVADYQPEMKSYQEWLKAADNALYLAKSHGRNRMERAVPQS
>A0A1A8T9M9|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MIERFRSLLIPCFIFLASVYGSLYISYLPPLWVALLPWLPVILSVVAVLLAWRFNKGRVL
VVICLLLVPKVYGHSSTESVSAYLAVSCFCIALLSFVRERGFFNRFVVNRFLFISMLLAW
CYAVDAKWVSFSFLEQPFLSFQITWSTLLLWCVLAISVIVTGCSWWLAGDVFCANALMSI
VGLMVMSLFSVSQDQVDLLLSAQCLVWLFFLLMESHRMAYLDELTTLPGRRALNESLLGL
SGKYALVMVDVDHFKAFNDTYGHDMGDRVLTHVARQVQRFSYPGRVYRFGGEEFTVIFRA
KVLNDIEPILDEVKAQIEDMPVEVYDPKKKKVIETRVTASFGVALSAPGELADAVLIRAD
KALYQAKRKGRNCIVFSKSTNHRSTKVNGNV
>A0A380A1C2|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MPLMAATINFDEVLADLEQLQHTDMQSAITKLHELEADFEHMTRFQQGRLLVFKGTSFIY
SGQYQEALDNLIQSENLVQNSDYLFSAYSYEATAYIALRNFKDAFVVMSKSLGLIDRIDN
IDIKRAAYLRLASLYSAMGIKEEVGTYAAKAESLASADNVKDICTAKLYLSVYQLELEAF
TKAFDEFQYTHDFCESNGFPLISFIALKGMGESKLRLQEYSAAVALLLKALKGYESFNFQ
LEINSVHSLLTEAYFALKQSAEVVEHAKFVTSLPNDPSYTELKHTVFKVLAGLNAENKQF
EQAYEYSKKEQYYNQLMFDEAKMKTLAYQAAKFNADEQSREINLLNKERELYVAQQTVKE
REYTNMLMFVTILVGGLFFLGILLAVGQMQKRKFMRMARMDALTGILNRGAGQELGENLF
VQATARGGDFCVILFDLDFFKRINDSFGHGTGDWALKKVVDSLKSHIRNGDVFARIGGEE
FAILLPYADEEKGMEVAEQCRARIEAIDTQHSGHKFVITASFGVSGLMADDLSLDPLFHR
ADMALYAAKANGRNAVVRYSDILKCDKQATDLRRHIASPSV
>A0A380WM15|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MWKIAFKASLVTIAIILVTQVVSFSIRHSAGQSFTAFVFAMNSILPVMTAFPAAFLIFWQ
NEKLSRALAELSEAHIKLKARATHDHMTGLLNREAFFEKSKQARRKCDSGALLVIDADNF
KSINDTFGHLVGDEALKLISKALRAAIRENDLVGRVGGEEFCVFLPTTNQDEAAAIAERI
RVEVERLAFYPVEGRPHRLTVSIGAVASAGQPTSQLMRLADRCLYEAKEQGRNRVVFARS
AIPAV
>A0A5B9MB64|diguanylate cyclase|EC 2.7.7.65|Stieleria maiorica|TrEMBL
MLSGERFSIKFARDAAAEDLLKVSMSASASQFDMSFELSGTSAKYSDTQCFEAGTLRADD
GSIPPDLRCPKRAFLNVIRSRADIGVNAFLTGRTVIGRNPQCTFPLHDLKVSGNHAAITP
VGDDQFLLEDLNSTNGTRVDGVPVVGRRTLTDGDKIFVGETVIRFSLADKFEIDFHSEVA
ALVGRDPLTDLPSKRRFDEALEFSLASSLRRDIPLAVLMMDMDGVKQINDTHGHLYGAHV
IGETGRLIAKVLGSSGQACRFGGDEFSAFLPDHDLQAACCVGEQIRGAVETATFEKDRIA
LRPTISIGVACFPETAANSLALVTAADAALYRAKARGKNCVMV
>A0A7Z7RLT9|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MDGLEALLQELDGIADDASLNVFMPKLRAFMIKLELQSQQEGRLATGLANLLKLMLDNVA
ELNRSDEYLLGQVSSLQEILSHEPLSMQQIYQLETSLKEVIRKQGMLKTSLDEAASSLRA
LLDRFVSRLAMMTDSTDEFHGKIQAHSEKLKQMPGVDELSGIIGSLMEDTSIMQLDLTRS
RDELVSAKEQVEAAERRISELETALEAASAKVKEDQLTGAYNRRGLAEYFQREIGRAERT
AAPLSVALIDVDNFKQLNDRYGHLAGDDALKYLVDTIKLTLRPADIVARFGGEEFVILMP
DTPETEAVQAVQRLQRELTKTFFLANNDKLLITFSAGVARWHLGEQEADVLERADHAMYQ
AKINGKNRVCSAEDMPG
>A0A2N9MBU3|diguanylate cyclase|EC 2.7.7.65|Acidobacteriia bacterium SbA2|TrEMBL
MSILSSVAMKPGSNSASDEKSPNGLSMSLPLLRALMLEDDPRDARLTASVLERGGYKVQF
EVTDDLDIFRDRLEQAEYDVILADFNLRNWSALDALEVLKHSDKDIPLIVVTGVLGDEAA
AECIKQGAADFVLKDRPARLPTAVSRALEERRLRDENKRALEAHLRLATIVESSGEGIVG
TTSEGFITSWNKGAETLFGYSAKEILGQSISSLDPAERAEEAQQILASLRRGGSIEQLET
VRVRKDGSPVDVSLSVFPLLDSRGEVTGVATIARDITERKRAEEKAQSTARQIKSILEAA
GEGIYGVNGEGILTFVNPTARRVLGYAAEELIGRSAHAIFHHSPPDGTPYPVDDCPQVRS
ILQTGLPLRCEDWYWRKDGSGFPVQLSAMPMKESEEVVGAVVTFSDITERKRAEEELRDQ
ASRDPLTNLWNHRTILAILDKEIARASRIHTPLAIAMLDVDRFKTINDTYGHLAGDAVLG
EASRRLRATMRTYDSLGRYGGDEFMAVFPGCDSAIAARLAETIRTRIDDKAIETPEGIIP
LTLSVGVAALGDLGEVKSETLVCIADAALYRAKTAGRNRVALATAEDIEKGVSKRFLEGD
LPGLDAPLTELAALQTQRDRLSAASFETSAPHPAAEQAVALGNLEATCLAAMEALVTALD
ARDHETFGHSHRVRAYARLLAQMAGYPAELLPWLERGAFLHDIGKIAVSDAILRKPAKLT
PEEWVEVRKHPETAHGILRSFPFLRPACDMVRHHHERFDGKGYPAGLKGAQIPLGARLFA
LADTLDAMTSDRAYRKAPGFAAARNEILQMSAKQFDPQLVDVFRRIPIDTWMQLRAKSGE
NSTLVT
>A0A1J5PVF6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MQILMDFLQLTEAEAQALVEHAPELLRRAHISTRAVREQVKILSTRGGMLDALSSDQCEQ
LVAMHQDHYRELLAPQYTLQLQHRMVEVGDLYYQWGVSPLWIMTTSSLFAADFEAFATDL
SLSQRRPLMAALYKRLRRDEVWQMEGYRYASDSVRRKLERSPLRDSLTGLLNRSALDEML
PTALDRARRNGTKVVVARLDFDAFRSVNDTHGTALGDLVLQQLADRLRRALRKIDLVARL
DSDDFVLVLEDIHRIENIAPLLERLQLDLDVPYTLSDTLLWQCPISMGITLYPDDNVDAQ
GLLRHTEQVLREVKANKAQRECFWAIYGQ
>A0A7L6YVR5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C16|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARQPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A1J5RPA2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MASRPSASAGRLWRLPLLNAALAATYVLLAWGATRSDPSNAILWPSSAIAVFGVWVLGFM
AAPGILLGAYIANAEVIGWPAQAALLIAVGNTASVLFAWWVLRRIRQPWRGLQDTGDTLA
FILTLGLLGPAISASVGVISSLLAAPPRLHDIGMLEPMWLISDACSVLVYAPMLVLWWER
RHERLPRPTAEFVILPLIALVGVAVLALSPPARQALPLGLASLALLPLLWGAMRLSMRLA
SLFMAVLFTLALVGAALGLGPMMVLPIDERASVLQLLGISLACTVLLASSLAQERSLALR
QLREANTGLERAVERRTKAMVKSQRKLQEQLRFQDSLLGALPNPTAYSAANGRLELVNQA
FTRLMERSRDALLGRRPAEVFEDSLLHTWTSMDRQLHAERRPLSQECRQVSSDGDATVWI
VNKAQVTDPASQEPLGIVTSLQDITELKRLQEQLERDERGLRFLVEESPVPLVITRVHDS
VQLFANRAADELFRADHTGRSGKLLRDLWVEPAQRRSVVEQVLREGVVRGLETQFLRYDG
SPVWLLLSVTHTQYRGDEALVFAFKDITPTKEREHTLRALAYTDPLTGVANRRSFLARAA
AALQEAKLQGKPLAVLALDIDHFKQINDVYGHPTGDRALRSFSQVCQQLARDDALLGRLG
GDEFAIVLPRSDDGAAYDFAQRLRLAVQENATAEHAPLRLQLTTSIGIAHHPCEHLTECG
LDDLLARADQALYRAKQRGRNRVELWTGHDHPGAA
>A0A1J5T5S4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MVEKKVPHTASASEGNVHLHNHFGHLAFHDPLTGLPNRDLFVERMNRELARVRRYESGFA
LIMLDLDEFEAVNDANGHDAGDLVLCDVANHLASAVRDVDTVARTGGDEFAILLDGVTSK
KEAEIVALKIIKSMSAPIRLGNGTQIKIGASAGIVLSPQDGYLAEQLMQCANQAMNVAKN
NGKGLIGFSRNLQTAPKASQPSPPPPGSMILGISILDEQHKAMSNFIQGIIESLKNGDHS
TKLLKRVELLVELCRIHFKTEEDMMQLYDIEGLDEHRTEHQVKLKNLRSIFGNLNFNEKE
LAKLTHDANEWLCEHIREQDTELVAQLKKKGVF
>A0A1J5QPU8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPFLGLNAILWRKMEKACNNTSNATRVVPIEASLRYALIIGNRPEGSNAAGAVLRLHGHR
RKTHHSKNMQQDRDSRENPATIARAALKRLAEEGVAPTPQHYRKAYFAESAQGATLGSGA
LLQRLSRLPLAKSPAWPALRDALGHEHWELALDLMAGMLLDAPPARAEPALGPAIARFVR
EWARSQVGVSHLNKLQALQTLEVSAESTELLATLQEHTARWAVLRERDAAATEDAAAAAV
EPWRRAWTDAVRMAEHAYAEQAQIHAQAGALLRQAGEVESFNDQLQAAARELWTACEHWE
TLTTQARARLLEVFKLLLDNVAELFDADHWVQPQVTALRELLRDPPDVPRIEQAVGQLKD
VLFRQGVLARAGDDARSIARELVEMVVRSLGNYVEHSARYGDELEAGLRDLDASPDWSRA
RDVVQGILANSRRMLDDTRQLRTSFTEAQTRLEEAHARTRALEDELQSVSEMLQLDPLTG
ALNRRGLEVAFERETARAQRGGDTLCVAMLDLDHFKRVNDSYGHDLGDTVLRELVRVARG
ELRPSDSIARMGGEEFMLILAGATLDHAAQTVARLQLHFASMRFSHSHQPAGVQVGFSAG
LAAWIPGESLESVYGRADRALLQAKSGGRSRIELAA
>A0A1J5T7X2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MQHENHTRMKSSGKLSSGSLSVQIDTDALINFQSAILKAVAFGSDDKEIIDHVCRLGEEL
VPGCLATVMLLDNRGLLNVHSAPSAAPEITIKLNGLCPGPESGPCGNAVYRQEPVFVEDT
LNDPRWNGLKTVAEEFRFGSCWSMPVFSEGRIVVGTFALTGFENRMPTSFQRKLMETAAS
IIAIVLERGKKNVALQRSEERFKQLFEGATDSKMLISDDGRILDVNRIAHERLGYAKSEM
IGRLVSDFVTTENIDKVNQRLDRVTRDGHATYESAQLRRDGSIMPVEISTVVIDMDDGKA
YYSILRDITERKRIEMALHQSEKRFRDLVETTTDWIWEVDDKWRYVYVSPRVQDLFGYSS
GDLIGKTPFDFMPENEISPRKEQSRALAKNGEAIYQIESRRIHKDGHEVIVETSGLPMFD
DAGRLIGYRGITRDISHRKKMELALRENEAHLRDIMQHAPIGLATVSLEGRFMEANQSLC
EIVGYTKNELKKLTFQEITYPDDLSSDLGNVKRLLAGEISFYKMEKRYIKKSGDIVWIQL
TGSLLRDAAGVPSHFIAQIEDISERKVFEKRLRLERDFSNSILDTAKSMVMVIDREGKIV
RLNHEALEFTGYTFDEIKNRAFFWERFLPPEQKGEVRKVFDKLISGDVVARYENFWFRRD
GSKRLFDWSNSILRGLDGKVEYLVTVGIDITERKQSEARLQLAASVFTHAREGIMITDAQ
GDILEVNNTFTLITGYKREEVLGRNPRILQSGRHEPGFFEAMWRSLVNEDFWTGEIWNRR
KNGEVYAEMLTISTVRDADGKILNHVSLFTDITELKLYQKQLEYIAHSDMLTGLPNRVLL
ADRLRQAMSQCLRRDSSLAVVYLDLDGFKAINDGYGHDVGDQLLINISQRMKDVLRECDT
LARIGGDEFVAVLADLDKPHDCEPVLARLLQAAADPVKLGDAVLQVSASIGVSFYPKDNV
DADQLMRQADHAMYQAKQAGKNRYQLFGMNRDG
>A0A2N9LKI1|diguanylate cyclase|EC 2.7.7.65|Acidobacteriia bacterium SbA2|TrEMBL
MSWFEWLIIGSIALLAGAAIGAWKQSGGYYWSKYILSAWKRSSTEAAVASKAVLVTPQRA
QRYATQESAAPLAGVTTRDRFFESLESEWRRSSHTGGHFCLAILDLDRFKQLNDRGGRRE
REKVLAKVAALLSAQSRDSNIVARHGGNEFAILMPGTNTLQAEILGERLRTVLETDELLR
LCEVTVSIGIAAFPDHGGTGEEILKVAESGVRLAGKCGGNCVKVAWPSPEPEEAERDKRL
LETCLQAAEKGILHAPRELSRGTPSTPPDTGRGDSPASRTRPTTAASTASQGEAKTDSLL
STLTALAFAEQARGPHRKDHAQVVSRLAAQMALKAGLTDAEVEEIRLAGLVHDIGKIYVP
EYVLRKPTLLTAQEFEIMKSHAAWGAKMVELLRAKGIERIVLHHHERYDGKGYPAGLAGD
QIPLGARMVAVVESFHNMVADLRYKSARTFEDALVELRRCSGTQFDPQVVSTFLEWVEMQ
VDSASRNAD
>A0A378REX5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MLRWGALPPRHADQYDWISVYLHDRDQQGIWRTLIFTATLALASSTALMIKSPQGPDGPV
AVTVCVVAAAVALAAAVPFLLRWPTRRQSLLFSFTSTATIAAAALSYSNDYVGLMGCATF
AVIGGFVAYFHTAHEVIANGAIAAICAVILAVRVVSSTGDIYLTAAAVAIVATLNIGLPF
GVLSLAQTLRVDLRSSGRDPLTGLHNRRSFHQSAYELIMRNDTAASRLMVIVIDLDSFKS
LNDTAGHAAGDAALIRISEALADNCGLSAIIGRSGGEEFVIADVDHPDSPDVVAERLRRA
IAELPVPVTASIGTACAPLNNGSHVNLRLLDELVEAADAAMYAAKRAGGNQVRHAAV
>A0A1J5QIN6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSEATTTQGDAMLADQASGGRMDAVARRSSTPLACFNAGTQRCTEANAAFAALFGTRAMI
GVSLPNIFEPASLAQIEPYLRHDAPDGAGGRIVDLSLRTQDGQVRDFDVSVVRYVNRNAE
PELCMLMHEVTRFRATARMAHEAMARLHRFMDASTEGIVFQRAGIIVDINPALTRLLGHA
AEDVIGRPSIGFVSPDDRDIVIGHISKGVEGKPYEIALRHSEGYDIPVEVLGRNVQFDGE
TLRMTLVRDIRARRAAEQRMRELAEHDGLTGLYNRRAFLDQLPTRIAGLAERRQTAALLF
IDLDRFKQVNDRHGHAQGDRLLQAAGQEIQAFLTPGDIAGRMGGDEFAVLLTGIQPEAAG
QRAQALLERVQTAFDATGLSDLAYASVGVALFPGHAQDANTLRRQADEAMYLAKAGGGSG
IRLYAPVG
>A0A1E3KYI0|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MLFKDLFMNFCILATFSFFGSMLLNYLNAHFKTSTYIKRQWIGLFFGCLGATLMQFTFPV
GDNVLLDLRQISIVLSISMGGSVAGIITTIMIMITRIILSPTIGLSAILGLINAATLCIV
ASWIFSRSMTFYKKWLYSGIALTIIATASLCIVLGRNEIDKVLVFIVVESAATLFIFMLT
RSLRKNNELFEKVSKEAQFDFLTGLHNPRAFEKKFEQLQHQETDMAHSLLFIDIDHFKKV
NDVYGHPAGDAVLFQLANVIQQSIRSTDYGARKGGEEFAVWLEYCQLTEAKMIAETLRTN
VEKKKFILPNGKMIHITISIGIGMYPALMWDELLEKTDQALYQAKQQGRNRSCLAQSSL
>A0A7U7EHN1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSRLDLQKLTLLLALVAGLLTFANSFFAGYSSQRDQLFDQTLEANRAYARKLADTTDQFF
VNSRRELAFAAETLSTRFDDPEARDSETKRLKLKSDQFSRAIIVSAAGEILSASPGSSLK
VGMKVNSVGATRALTERAPLITDPYTATDGIYLIAISHPIFGADGSYRGFISASLFLRER
NALHGLLGVHYYRDGSYLYVVDTQGNLVFHEDGERVGQNVSSNPVVQQVLQGQEGSQRVI
NTRGVDMLAGYAPIQSTGWGIIAQRPTAAITAKLTQLARATLLNAVPFAILSLAVFWWLS
KLISSPIRALADTAEHWGAPEAAQRISTVNSWYFEVARLKVAMLTGVSLLQQKMGALEAA
SMTDPLTGLRNRRGLELALKQFELLDQGYAALALDIDHFKQVNDQHGHDVGDEVLRFLAA
EMRECSRPTDVLCRMGGEEFLMLLPETDATGASVAAERLLTRLRQTTSPTGTPVTASVGI
AFSGDYPNADATFKAADAALYQAKRAGRDRAVVAAA
>A0A380AMH8|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MGEAMNARINARHGLPLTVQLINLFMLAFLLSLVGILSRPIGSLSLFWPVNAILLGLLLR
KPIYATPLGWLTTYLGMIVADLITGEGWSLALWLNACNMSLIAVGYGIMLMLPQSQRRMG
KPQAILYMFSASLAGAAVASTLSVLRNDSLYNNTVVVAWLAWFSEQFSTTLLLLPVLMAA
PRLKQLLRMQVRWRLKGCLPLLALLLSLVFSVYIGGPGAIAFPIPALLWCAVRYQLFPVT
LLTLLTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAANRK
LMRRLEHSANHDFLTGVLARSAMTRKAGELLEHKHRSKEAVSLLLIDIDHFKQINDTHGH
SAGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALAAQGVALGEHLRRLVEQTAL
QVEGKQTLKITISVGVASLAMNEVKSLEQLMNMADIALYRAKSQGRNRVESFNVVNGNSV
EHILFR
>A0A1C3HMV8|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MNARSYQELLNSKQRLALFLFLVMNAASSVFTLLFPFRDTPAFTLPLLCIPLFCLAAALF
SLQTPRKYLCKLNLFSSVLGLLWAAHIYVKSQYCLPNNQDFLLISLFSIFFISAISLTDN
FTAFCLHAVPSAMVILALDGMHNTLRILFTTLLPIIAFSIHHLMLKRSEIFTHALVANLY
NERDKFNNLSMLDPLTGLYNRRGLENKINMLLEPQTGRHYVLLLDIDHFKVYNDSYGHAM
GDRALVQVAVAIRDAVRSRDIVVRYGGEEFLVLLTNVHEGYAAQLAERVRQRVAELNIPH
GASPQHSDTLTLSAGISALEKLDVESAIGAADAALYLAKHSGRNNIQLAQNVQPAAIHP
>A0A2H5WC13|diguanylate cyclase|EC 2.7.7.65|bacterium HR12|TrEMBL
MAGLRGEVPIDVLAVGPTPAPEGEGLSTERAETLQGALDRLDERGADVALVALSLGPEAI
RSLRERVPELPVVAVADDAEAVVALEAGAHDVIPPGADPATIRRSIRYAISLHRLERELH
RHRVVDELTGLYNARGFEQLAEHHLRLADRTQEPVVLVFVRLNDLTRVSETHGAAEGPRL
LAETAEVLRQAVRDSDVLARVGTDAFCVLLTGNAAGAEAIVLARLVEAVAARNARSGRTA
PLSLSVGAARYDPADPVPLAELMTEASRRLQAPG
>A0A2H6B791|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MFGREGADREFRAALRELVTKRDDLYAGADLRNARRMMALTLIIGVVVGVMLLVVAIPAQ
GIKLGALLLELAYAAFSLAAAYWLFASDKVTFRHLWVLNAALIPMLALLVWQSGGTSSPF
NQAYLLALIPAAGIHPARRALPLLGLISLGILSPLLYEPYSYDKLLLLLSHMLPWYALSG
AFLILMTYVRLQRIISGENEAQARRLARIDELTGLGNRRAFEEALDLELSRLERSGSTLS
LLLLDVDRFKEINDTWGHPAGDECLRQVAVALASAARATDACYRWGGDEFAVILRETDHA
GAQRLRDRVRKLVAASCQAPDGRPIRVSCGIAQAVDSDRQALIERADVDLFRDKTGPHRL
GEDTPEARRIVSEEGDGDDEKPSPAPWHYDPAHGDSGHSGPR
>A0A1Y6MD01|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MNISHSIRKKIIHYTLLCLSLLIVFNISYWSYNQYNNIHKLLSRNKTVTENNVATIISKH
TNLLTAISNDDIVKDTSLLLTQRIEIVRPYQEAFNIEILGISDIKGNAVTTYSDSIENIS
YRSYFQQAIQKNKLAISNLIYSPISNSYVYIICKAFTNADDSGTIFASVSYAEIKNALAY
QENTSIRNAILNNCRDSNNNCRNIKVLKGDKLYSSLDSKQISKNITDKKTFNYYTINNNY
QLERLTLAPLKNTPWYLLTTLNYNQYLKDKFIFIIINILISILASVGLGFYLMKKVSIIT
SPIDDFIKESAGIIPIQSQSNNDNIAINHHFNNIISTTKDGVYCSRTNLFNRKYFIQHAN
ATIQKYPADFALLFIDLDNLKTINDTLGHHYGDDVIAMFAQHVTSFFNHPTDLIGRFGGD
EFIVLTKNFNKELDLIAKLQQLIVDLNGSVSNATLTIPFSASIGVALTDNETRDIEQLII
NADKAVYDSKKKGKNCYSFYIRH
>A0A1Y6MB92|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MSGTLITAYRSFNKILKHLPVEGSLPEMLLRVIELTETTFNDRQTSILLFDKSKNKFTPF
NNNNHNLTCRERFMINPAKIHFESICSKKKIIISEHITTNNEYRKYYSLKTINHLNSCYG
LPILSSRNKVLGIIYSHCPHNSMLTDDEYELLEMAATVCSIAIENNIKQQELNHIASYDC
LTNIWNRRAFYRHINKAIKNIKLKDEYLAIFYIDINNFKKINDQYGHRFGDRVLKKYASK
LQKMTNEKTGAARLGGDEFIIYSEVHTQIEADIKKMSILSQLSHIEIDDILVTASIGTYY
IHASNVNNENIDGIINHADMNMYKEKHLLHS
>A0A3E2KN85|diguanylate cyclase|EC 2.7.7.65|Citrobacter gillenii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMITHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSIPVDVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A1E7WIG3|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MPRCNIHRCLFLLALLLACVAPSHATERWSRLAHTAFKHHQQPDMTGGNSFAQDRQGFVW
IGTQTGLVRWDGSRYLRYMGDTTRTDALPDSYILSVHIDWRGHLWVGMNSGGVARYDAAH
DNFVRYRAVPGGLASGDVGAITDDGADGILVGHGAGIDRIDAAGAVSRMVYAAGAALPAG
GVSFLLRATDGRLWIGTERGLFLMDQDRRVRPVALVDGAALPIGALFQDSTGRIWVGTRA
NGAFLVDAATLKATAVRESGPVSTLQQERVVSIIEAAPDQVWIGTDGSAGGIVVLDVLSG
ETRRIRHRADTPDSLLDNNIMTMFRERGGIVFVAGMGGLSQHGPVSDAVTTVRYLDPDAA
GVLSVPSMMQAPDGRLWLSIAGGGIKIVDPATGQVSSVPDLPKGRVLAIVPGPDGEIYLG
TQKGLYRADAQGRRARLVPVPGRALEEEVWALAVRDRVLWLGDLEGVRALQLPPAGSRDT
ARLLRHETDRLGDPRVTALLIAGNDLWIGTRTGLARLGRLDPASASVELVPTELAAADRL
APGYVSSLLLDRQGRLWLSNFGIGVIMLERTDADGQRHFRRFSKLQGMPDNGANMVLEDV
DGAIWASTDTGMARIAPGTLAIQSFGPGDGVQVPLYWTNSGARTAADELVFGGLSGLTVL
RTRALAPWRYAAPVAVTRIVLGDQEIPGGSYNIAGRRAAPITITPEGRERGFSLEFAALD
YSAPERNRYAYQLKGFDRDWIATDTISRRASYTNLPPGDYVLLLRGSNRNGEWSAPLEVP
VRVLTAWHQQPWARLAAVLLAALLLAGLMHARTRYLRRRQHELEAMVEARTAELRATQAQ
LETLAYSDPLTGLANRRLFSDELRHLVAQAERGGPGFTLLLIDLDHFKPINDTYGHDAGD
ALLVATAGRLLAAVREEDRVFRLGGDEFAVLQGRTTDRATLEPVCARILHNLAEPLLLPQ
GDTIEISVSVGAALHQSGHSHEQLYKQADVALYRAKGAGRNTWHLAES
>A0A1E7WZF7|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MSTAPDHPDAQEYEALLQFMYMAPVGLVQLDADGAIQMLNPVSAQLLMPLSRDGELINLF
DALAPVAPDLRQQCASYAAPQGPICDAIRLYVHADDKSGGPQVMSLSMLKLDADRLMAVL
TDVTEQDRRERQLRKTDAWLNAIMTNISDYALVSLDRQGRVESWNESIQRVTGYQAEAIK
GQPYARFYPDGATTEAQQLDRLREADENGWTLDEGLRQRADGSEFWGSAMISPLPARADD
TAPSPVPRTDDDPAYCMIIRDISDRRDLSENLRKAAYSDHLTGLSNRRAFFEAADLELTR
RLKAVRPVALLVIDADHFKAINDRHGHPAGDAVLAHLAQTMRSVCRQVDVLARIGGEEFA
VILPSVALDDARVIAERLRAEVVRTPALYEQQTIAYSISIGVAVMDDTLTGFDGLIKRAD
EALYAAKRRGRNQVAIWQNPAPEQA
>A0A1E7X897|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MYLDLDGFKPINDTYGHAAGDEILKLVAQRLVSCARKEDTVARVGGDEFVIVMGNISHVG
DTQEPANKLIESVSQPYIVNGHTLQLSTSIGIGIFPDDADAVAAVIAVADAALYEAKRSG
KNRSCTAQTLRTQSPAEPVLSTAV
>A0A5V6Q252|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cardoner|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6J5FZR2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia caffeinilytica|TrEMBL
MRQPAPPASPPRASRPTLQSVLRRAHLRLAFVAVAMAAVSLIVVAVIALRAYAGNNLNLL
ARSLGYTVEAALVFGDRIAAAEAIGEIAGKEDVAEVIVTDGKGLPFAAWQLPADSAIARL
ERQVAGIALPGPVTTLVLHDGIVVGHVEVHGQGRQFFGFLLGGIGGILACLAISVFGAYV
SSQRLLHNIVAPLRALADVAHAVRRERAFEQRVEPVAIAELNQLGDDFNALLDELEEWQN
NLREENASLEHQANHDALTGLPNRVQFEWCLERALCGAAETGQRVAVLYLDCDHFKEVND
CLGHEAGDAVLIGIAARVRMQLREADLVARLGGDEFVVMLTPMREAASAGRIAEGLLASM
APTIVLPDGRTVATTMSIGVALYPDHASDAIGLLRAADAAMYRAKRAQPGSWQFAEGVAG
PA
>A0A2T7YK87|diguanylate cyclase|EC 2.7.7.65|Bacillus thuringiensis|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEGFSFGQKCVVGIFTGILGIVLMYFSVRVGT
ILLDLRYLAVILAVIIGGPIASTITIGMILVTRLLFMDYSLASQVAFYTIIAIGIGSIFI
SRMKLSLGGKWVWLHTYILSILIPALYIWLIKEIHIVGLYLISSIITGYITFISANYVLQ
SNELFQKMKQYATIDALTGLGNVRQFDLEMNRHISNKNMKNDSFCLLLIDIDHFKYVNDT
YGHPAGDEVLKQVGCILRETSQFPDLAFRKGGEEFALLIPNKGLAYGIRMGEQIRTAVES
HSFQLLDGTKIKITVSVGVSEYEESPEQFIQAADDALYYSKRNGRNKVSSVS
>A0A6H9HFZ3|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. TCA1|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>U9XZ72|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 113303|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLYQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A518D0D1|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla163|TrEMBL
MSDAFASTGDGGVFSLPQIRHLLRVEFARAQRYGYPVALVLIDFAPVRRRVGDTVFDAEA
AGIITRLRELVRTSDYVGRTESDRLLVLLPHTASDGAVRLARRASDSLLSDTRPPADGDD
APLAPAIGLASFEEGTILFFDALLEAAEESLEQVEGSGTGSVRIL
>A0A857JIL1|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MAAIFTKYNRPGCIQGTMLTSIVYLLLSGLLAIFVHLTLDKVIQAQANAAQEVNISGQQR
MLLQRASLFATAYLYSEDMAAKQTSLQALGAMQANHQQLLEPHYKALKSGSISPLSTELQ
ALYFTIDNNVSDQLNAFSEQIYSVLNRQIDQGTTKLDAKALMEMAYTPLLNRLNEVVYQY
ESQNKVRISTLKLVQFVVFWLIVAMMFIGLLFIVFKARKQRTRTTISDILQVDVEQSNPM
FNHKAFELSASKLIATARRHNETMSILAFDIDRFSRILTHQGHDMAENVLSHVAQGLLMM
SRESDYLGRVADDKFVLLLPKTSAAQALCLANKIRTFFNDTHAQGAPNGMHISVSIGVTE
LEKEDSMLQHIISRAESALRRKVNQGSGRVCMA
>A0A2W7T8A2|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MDKPLRLKINKLRHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMLSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTL
PVFGVSGSVVGNNPILLKDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMTHYSQAISALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLSVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVL
PNTTLQDAVAVAERLRQRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADR
RLYLAKQNGRNQVCFRSEA
>A0A7H4SHB8|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MSLKEMRNGIYSTCPETQLQHYLRYLDTMTEIFEVWTLQTGKGLQSVYCKTTLVDTDDSG
TLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFGPFFYDQYRADAIDRSQ
>A9MMJ3|diguanylate cyclase|EC 2.7.7.65|Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A7H4MHT9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDINAQRQQVMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVAHRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQKQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFAAARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTILRQALCGVYFLGEQRIDYEGASFGV
IICDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A379J027|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MLQRFAFLLALLLGLSTTGLAMASVTLTDASSGMPLNAYIELLEDTDGSLTIDDLATPEQ
QSRFHPANGRASVGQSLNPWWIKLTLQRDMRAPARWVLEVGSVTQLDLQLYQPNGQGGWQ
LRQSGERVPFSESRDHPYRRMVFDLPILGEQPTTFYLRAFDPAGNSFPLRIWQLDELTQL
AARENLALGAIYGVVFALLLYNLFILISLRDKAYFWYVLTTAFALVFIISMTGHGAQYLW
PNSPVPSWLDRITLPSLWGLFACRFTQTLLQTKLYVRWAHHLLSMACVIYIVAIVLNLSG
QRYLAAWAIALLSLTSIPAALGSAVVRWRQGFFPAQLYLYGYGLVLGSVGILLLRTTGVL
QPAEWNAYVFPLAVAAESILFSFALAYRIQILKQERAVALQQADREKTARLAQLQASADE
LQAAVTARTAELAATNEQLRERERELQHAAFHDPLTELPNRRYLVERCESALGHAERHKE
SVALLLIDLDHFKPINDRFGHAAGDLMLQVIAKRLREHVRLGDAVARLGGDEFAVLICGS
DAESQAREIAERLLAELSEPVHYGAERLRVTISIGVALYPRHAQNFTGLYKIADHALYRV
KELGRSGARVHGDDGELSEQACLQLDVLKVPSGLA
>A0A448C9V9|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MSSSKSALPAWASSADQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFY
STLLADVEAGPRLSHDIVSTRLHKGMKHWLLGLLCVRDQGDIVALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAERLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALGQITEAVMRLDDVVLPSLMLDDRERQLSLPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISISSRQGSRFSVLLLDIDHFKAINDA
HGHSGGDHVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGQEAALAAAQKLGAEIRR
HDFTIPEVGALRITASIGVATFDGHPDYAYLIDRADKALYQAKLAGRDRSVAA
>W9VR69|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MKSIKGYIALTSVVFALFLISVLGLYRFYIEHPKEIEIAEQLQLQELNSLSKILRLKKAT
LASITLDWAHWDDSYQFLTEPTQFERFVQSNFTPSSFITNKLLGVVYLTNDVHVHYSQGY
DLSNETLVDLSQISNIDWALITHRFNQVDSDVLGGWLLTRSGPAIYAIANVTDSLSEKDP
AGYLMFIQLLSESEIEFIESITRLKLNFTTPTTEDELAFANTIPNLAPVTLEEGFQTERD
RIIRDDTNTPMVTIHITHTPIHSPNLLDGFPFVFAITGLVALLLMALLERIVHRPMKKHI
QAIEQMVSEQNLTPLTERFRINEFEKFRSVFNLAVDLVQQQKLALLELSTKDALTAIPNR
RAYDTFAPTAWKHAKRHNTTFCFAILDIDYFKQFNDSQGHQAGDVALKQLGALFSQHFCR
EDDFYARIGGEEFVVILRSSHDDFLPHLEAFRQGFEDLNIPHTSRPDALKVLTISIGAVI
VKHPNQLSIESGLTRLYSLADQTLYTAKQQGRNQIGVRYINHEKG
>A0A7Y9Z314|diguanylate cyclase|EC 2.7.7.65|Sulfitobacter geojensis|TrEMBL
MQGKILIVDAIATNRIVLKVKLKKAYYDVSFAATMDDAVKAVRADLHDLVISAFALPDGN
AAELRRVLATSVATDHIPVIAIGHHEDVAQRMAALEAGVHDVLPQPVNETLLLGRVRSLI
RAHNTTSEWRMREDTCRALGLAEPETGFEDQCRCVLVSTDTPQLQTFAMHLRPVLRAKLT
LSSSATLMSEITIDALPDVFVLVLPENATAAMEDLRLISTLRANASARHTGVIVLQTRPD
AGLGAHALDLGADDLMTHGFDAAELALRIKAVMRRKRMGEQLRASVRTGLQAAVFDPLTG
LYNRRYAMPHLERISQHASKTERSFAVLLADLDHFKRINDIYGHSSGDAVLVEVSNRLRS
SLRSSDMVARIGGEEFLVIMPATNLAEAQKAALRICGDISATSFVVPGSSDPITVTISIG
MAIGGGDAQPEQDCQKNGMTLLDEADCALYAAKGRGRNQVKLGRPAA
>A0A6N3IA73|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. 86|TrEMBL
MAPDEKKDACIGINAFLSSGIVVLGLIFSASFFYYMNMARDISVASTRIYGAYLPLTEAL
DQVDRQKQDLWRLLGEVALAESGAQSRQDVQAAIAQLRKAPPPGAIVQRQHWEGALSALE
RLAFLHAQAHDLEAALHSPPVAQNAGLRHDGDHDDQDATGNAASYAAGRLVAVRLAMDAA
LTDFTSALSNIEARNPLADEMHGQLRRTAALAHDFENRLLLGFLFLGAGMTSLYAILRLQ
LARPLRGIMAYLDQLGTGVKKLFLPRSRIVEIRNIASALDNLSTYLSKATIQSNKLVSEH
DRFQKMSLVDGLTGVRNRRSFDDSLRALWRFAQERQQPLALIMLDVDKFKIYNDNYGHQA
GDECLKRVAAAMTRAARSTDVCARYGGEEFALLLPGADTHTARAVALRIHNEIEREQLPH
PASPVNGFVTVSLGVASLVPGKDAASDGKLLVRNADAALYDAKSAGRNRTHTYGEEMACT
PTAQPA
>A0A6N2XRB4|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKPSIWRRVDIQVSLFTAIVVALLTFSIFWFQYRITYNDTLISLRDQAEAIYGYVEKRLD
KSTFDLVRTREDMEGDVYKQAHEAFQRIREISGVRYLYTAKMNEDGEFVYLIDCLDQSEP
DFRYPGDLIEHEIYPDMQRALDGQKVLPDRIKDTEWGKIFITYMPIYDGEQVLGVVGIEF
EAGHQYDTYRSLRLLLPLFILLFSLGACLASRLLFRRISNPFYRDMSNTDYLTQLKNRNA
YQLDIGNRIAGKAQEGTGFILLDLNGLKHVNDTLGHDAGDVYITCVSKAYLNMRTREAVM
YRIGGDEFVVVMPDADRDKIQDFMRRFGDMFNREASMPEFTFSWGYSIYDPKADADLYST
CRRADKNMYMRKQQYYKNKNT
>A0A6N2TMV0|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MSAVKYRIFLIVSAFLLSLCFALPVRAAEKVRVGCVDIGDFIQIDQDGYAIGYGADYLNK
IAEYTGWEYEYIQAPWGECLDMLRRGELDLLLPAEYSEERAEDFLFSSYECCFDFAALVG
RKSDERLYYDDYHGFQGIRVGMIKDNFLNHLFDEYAKNHGFTYEAVYYDTGTQILEALER
KDVDAIINGNMEYNMNHKLLAKIDYMPAYFITSVDKPGLMVRLNKALKQIFIDNPYYSAG
LYEKYYHEMDRQFAEFTREESQFVKQSRPVSVLVARSDYPFEWYDEKEKTCKGAYVDYMR
HLSKVSGLNFEFIPLDPGEAFSDELFQENAQIRLSIFKQKRGGMSGSLKYTIPYYNCSFS
LVGKKDEPLNLSSHQRIAMVEKVDGLQDVLEDKYPKWEIATYDTPKDCLTAVENGTADCA
MVSSIKLSADRNLLGMNLVVVDGSTAVVPVYIGVSDNANPLLAQVLSKSIAKAGEGAMDE
AVYATLLSGKENKDFSYFIQTYPLYFAFGVIAVSLLGVGILFMRYDARHQKLQNLILQKK
NEELKAAIAMQTLLRRKAQTDSLTGLKNKSTTEELCRTCLEHAQGDICALFILDLDNFKH
INDERGHQAGDVVLRAFGDTIHKCVRQDDVAGRIGGDEFMLFMGGIKDADHLTRFADRVY
KALKDNPDFNATCSMGIAVARAGSISYEEMFGMADHALYKAKENGKNKYHIEYIQGETVG
GRDSEAAGNSESAGASEAVAPSRNI
>A0A1V5BFB1|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin035|TrEMBL
MNSIPLSIDDHIIKNLPKRYLLAAILCLIGLGTDIPWLSQNAKEIFILRGLMVSGALLCS
FLSKYCKTRSSAEALTTMATLGLITNMAVIGSLEGTFLTGYMAAVYQTLVFLVVFIPMRT
KIFAGLLAGVGLLWFWILPVILPISLEPRLFFSHIFGYITYAFMSMAGNYFFFQVWTEKE
KQRADLEDQSHKLKEIANRDGLTGIYNFRYFQDKFPEFVKNAKKQSTPISLCLIDLDGFK
SINDNYGHVVGNSVLEYVSKCLTSSIRTKDVVFRIGGDEFAISFPDVNSSHARQIIERFQ
NKMTSMQPKEKIPQVNCSIGIAEYCQQLPTANAIFEAADRALYKAKKLNDNKVVVFSPDE
I
>A0A8B3WJ71|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MRSYSGFKNQRFKTYFDNEIYLPYINFIYIPISIFCAFIITDYIHFGTECVTPIIFRVLL
FLLMMAVARYCITNKPNVLELIESTFLVISSLFLVYVGRLAIELSNFDYQGGIILVMIYI
GTFSRLSVKYSISTLSFIFLAYLIGLAPQLYEAEPSHEIETISVYASAYILIAASCLRRD
FEVHKRFTQSEQLRKQAIQLRKQSNMFEALSYQDALTGCYNRLYLHQVIEPSIDRQLSIT
SIMIDIDHFKSINDTYGHQMGDMVIKELADEIQKRLPTSSNCFRYGGEEFLVMVQGETEA
SIESLVNSLLESPSLLRLEVTISIGVKHALQALGSVEQLIDDADQALYISKKSGRNKITW
SD
>F5NUH6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MYVVDYCPVNYTATWGINYTKILVCLWAFLLFFIIMRTRLASELCPLIALLCLASLCCNL
LLLTLDEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYF
FNSVESLLSRPVVKDFCVMLVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQAKIIAER
MRKNVELLTASVTDMMFLNK
>A0A5P9C5B6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSLPPTRHTQASLVLLLLFLLGSGFLTTSLLSYYASRDSIRDSIINTELPLTSDTVYSEI
QKDLVRPILISSMMARDTFLRDWVLAGEQDTAQMTRYLREVQEHYGAFTSFFVSDRSSTY
YQSKGVLKRVKPDEPRDVWYYRVRMQPEPYEINVDVDMANADRLTIFINYKVVDYDGNFI
GATGVGLAVDAVVKLIDDYQQRYERSVYFVDTTGRITLTGAQGGPQGTKVGDSLADIPGL
SDMLEKLPSPQSGRFEYQEHGREHFLNVRYIPELEWYLFVDKHDKALAGIRQGLYINLLL
CLLVTAIVLTLVSLAIRRYQQRIAALATTDVLTELPNRRGFDILAEQALQEALREQSPLC
AVLLDLDNFKLINDEHGHLAGDEVLQRFARQLRDKLRQSDILCRWGGEEFILLLKNTDRQ
AAHDLAEKLRQQCAEQRYAIADQTLQVTASLGLSQWQPGESLHSLLGRTDRALYRAKQSG
RDRVCVEQ
>A0A6G6JMD2|diguanylate cyclase|EC 2.7.7.65|Pantoea stewartii|TrEMBL
MIVDALASSDKSPNSWLHACGLGLVSFVLTLFCLELIVVSGKISPLWFSTALMTVVVFRC
TSRQLPLFLVACLIGTAAANAFVIGPALSNLKFALLNLLQAGIGGMLLRALLNREAPLVS
LRDWLRFVFATGVISPLIGGVLALWVLQVGQQASFAFFYTWVISEIIGMLALGPVLLLLS
WPLPKGYLRRASLFETLFSLVLTLIASYLSLRFLPWPFTFILVVLFWCAVRLPKVEAFVL
FFLNASFMALLLSLDWIIVTPTTTNYAMIVSWLPFLMVLIPCHIMSLVMDAFRHETRHIS
ESETRFRNAMEYSAIGMALVSPEGRWLQVNKSLCDTLGYPEYELKNLTFQQITHPDDLGI
DDGKMDKLLAGEILSFTLEKRYFRKDHEIVWVRLTVSLVRDSEQQPLYFIAQIVNISELK
QSELVNQRLMERITLANEAGGIGVWEWNMNSGEMLWDKRMYTLFGLQSDEVPSFDLWIKL
VHPDDRAFCVQTIQQAIEESSAFQMEYRVMREEGHYWIRSQANRLLSQEGRIERILGVAQ
DITPLRNLNEALFQEKERMMITLDSIGEAVISTDQAMRVTFMNPVAEKMTGWSQEAAVGR
PVSELLHITHGRHGAPVENLMINPTHSEKTAPYLSEEWVLHTLNGEHIDIHYTITPLKSE
SGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHHLRSTDFLARLGGDEFAVLMPECLV
DQARDVVQRIVRAVNDYCFEWLGRAYQVGASAGMTQISPNNCQSSDVLSQADIACYNAKR
SGRGRYMVYEQHPLALTGSHHSLDQVTLDALQVELQVWAVAPPGKPHSASVWLIEVQLFT
REGLLVDEHLLRNNLTDAALKQRLEDNIVEAFFRHRIAAMSQKGIALILPVDVNALYNPV
FVEKLCIRFAESGLANSNSGIALHAASVLSGGEQLLGTLMKLRQAGCRIVLQQFGRNLDA
FNQLTGKVVDCLILAPELVANLHNNLMDEMLISIIQSQTNERNIILLAGPVSVPAVLTTL
TSLDVDGVWGSAVAERQPLSKLSEDHLFAIR
>A0A7Z9BY10|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MKIEYRDKEGQQSLRMIYAVGLALIVTTALGVELYYSYQFTARNAEQNIYNTAQLLAGKI
SSRLPEIARGNKYLPPHSLNFNLTQERSSLDVSVLNTEIKNIDQSQQSVIEILDLELRVI
TREPNLPVYQNSSVNIQLLQDFVKQNKNHKIAVLRSEFDHKKRIVGIQRVEGYPLIIVIQ
VGFFDVFFLWYTKAIFYTILVLIIISLLTILIKKENNYLQQTQELMTHFVAIESADDMIV
ITSKDGTIEYVNPAFTKITGYQANEVIGHKPSLLKSGCQNKDFYQALWKKILSGKGWKGE
LINRKKDGSTYCEEMTIAPVKNSLGEIIRFVAVKRDISDRKQLEAQLAWLAHFDKLTGLP
NRVLFFDRLERAIAQAKRQQTQFAVFFIDLDGFKSVNDCFGHQNGDLLLKEVAKRLSLSV
RQSDTVARMGGDEFTLILGNIRQRNDVIKIAQAILFTLSQGCVVNGQECQIGASIGISFY
PTDGSDLETLVNQADTAMYRSKHQGKNRYEFASTEEELTRITNYEL
>A0A086Z164|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium actinocoloniiforme DSM 22766|TrEMBL
MSKPIEASIVVVDDEPSIRDLLVASLHFAGFEVTTAASGSEAIEVIERTQPDLIVLDVML
PDIDGFTVTSRIRQEGVSAPILFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTHEQAEDSPILRVGDLEINEDSHDVTRAGQPIELSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGVTVTGPDGRSSKVEPLIQTKRGIGYMIRG
PKGSMDER
>A0A2G4AWJ8|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLFDKFSSEGVQKNIDVDTWVSILDNIRDIMDASNAGIIMISDLSCSGSESVWSSSNISC
NQHKSKISLFCEYVHNENRTVYLSGHAGGDSVSANGADAYKSFCGVPVRDIDDEVFAVLL
VFDLSPTAYTESQVSLIENISTLLRSEILMKEESRILYKNSHFDIMTTLLNRRGFFHEFN
KANISDGEIVCLYFDLDNLKYINDTYGHFKGDDYISGFASCIKNNAKYNIISARVGGDEF
IVVIHSEEAGYASELLNNIHAEFDDFIEGFRCDDEVPLGFSYGCGTADSRSFNIINLIKS
SDENMYLNKKNKI
>A0A379I4G1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MPDKSNSMDKKLKQAIEQRIVIESARKTQVDTLSNFAAKLSLSCKGLDIELDNRLAKFRS
ALNKGVSFEHLSPLINDILVLLKSQEATQLAHQRDLRTSVKNAGKQLQKTNGLPDDTRRA
LRNLLDNELNNVQSTHGFIPLLNQLITIYNQALQTKFNAIPAEQHTDTPVIAKKLLELAH
QLVLEDEAAEQIQSIITAILQSNTVDDLLAAAIEIISIIVKNINNERQSAQSFLVSLNKT
LEELHHSIFSTSKHSESMGIEFDALNKRIKTKINNLNEQTKSTTSISSLRKLVDHELKSL
GEDFIAKEELERKDRKILITSFDEINNRIGSLENKLTKYKKRLNDQRFKSLLDSLTKLPN
RAAFDERYNHEMHLFNVQASDVTLAVIDVDYFKSINDRFGHTAGDITLQVIAKALQKSIE
KTDFIARYGGEEFVLLMPGTSLEHAIPQLEKLKKNIKKIPFKFKDKQIEITVSLGATQFK
QGDTLLKAFDRADDALYEAKNAGRDRLCIRK
>A0A085GHX3|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis ATCC 33320|TrEMBL
MESSTYLDEDRHRSGRRFARRLYIPRIIGLATGFFCVSSVLVLQPVSGWWWLLLVAYGFI
WPHFAWQTADRSSDPARAEIRNLMVDSLMGGVWIAVMGLNALPSALIFTMLCMNNVGCGG
VKLFGMGLGVILLSCLLTLGLARIPLNLETMPSQVWICLPFLLVYPVYFGLVSYRTALKL
SEHKRRLMQMSTRDGMTGVYNRRHWEHLLHGEYDNCQRYQRSATLLLIDIDHFKSINDSF
GHDVGDEAILAITEHLQLSLRITDVIGRFGGDEFGVIMSGTPQESAIQAMARVRDYLDEF
RLPRAPHVPLRISVGVAEFNKHMVNYREWLKAADVALYKAKKLGRSRTEVADIAA
>A0A383RP84|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MPSRSALFSQRSLILALLILLACGFLATSLLGYFASRSAIRDGIINTELPLTSDTVYSEI
QKDLIRPVLISSMMAQDTFLRDWMLAGEQDTQRVTRYLNEVMDQQGTYTAFFVSEHSHTY
YQAKGVLKQVKPGTWRDAWYYRVRDMQAPYEINVDLDMANQDKLTVFINYRVLDYQQRFI
GATGVGLSVESVVKLIDDYQRRYQRSVFFTDANGKVLLTGAEGGPHGLRAGQQLAESREL
EELLARMPTPGAGSHEYQDSEGHSHFLNVRQIPELDWYLLVDKRETGALDRVRQSLYLNL
AICAMITLVVLSLLHAMVKRHQESIESLATLDSLTGLPNRRSFDLLAGQALQAAQRDRAP
LVALLIDLDHFKVLNDTHGHLAGDEVLRQFATVLQGSLRQSDILCRWGGEEFIVLLREAD
DRGAFDVAEKIRRRTEQLTFSYNDQPLRLTTSIGLSNLQRDDTLHTLLTRADHALYRAKQ
GGRNRVCSEMHGSEHA
>A0A085GC35|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis ATCC 33320|TrEMBL
MFGNAIQRVISRFKNPQKVVNLCFIVVFIFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHNIDNLLFYRNSMLYALQSPISTDKTRKTLADFDSLRTQPYWQLRLDLNRSLPM
NGVSDEFVNNSPLLDRDEQTIHTELSSALELSYIMRLSHQTQTLPQRMFYASRSGFFLTS
TPPSNDPQIVALYYRLVAQPYFSSQSPENNPRRELKWTHTFNPNMSSGQIITAAIPLDYN
GRWYGVLALDYPIDSLHTFLRQAHNNEQHEGTVLLYDNELNPIATSAKSLPKHPLFTAPQ
LARIASVVTAAKQGAQGELRMDSRFITWAKLNNYDGLLIKVHTLEEGVQGEFGRISVVLS
VLWLLSTLMLFVSWVVIRHLVSNMFSLQQTLTWRANYDTLTRLYNRGAFFEVASKLSQEC
QQQGQPFSVIQMDLDLFKSINDRYGHSSGDKVLAHAAAMLSDAFRHDDVAGRVGGEEFCI
VLPDTSLEEATKVAERIRVRINSKELLLKQGSTVRISASFGVSSAFEFNDYDFERLQSYA
DHRLYKAKQDGRNRVCNTD
>A0A1V6FCS2|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin087|TrEMBL
MRLFQTAALIFGIGAAASFFSGYFLTDGDFIREIILSVSIWFFAIFFLFVPHITKKILIQ
NILFFITSVVGMTFFIVKDAHMGASTVWAVYIVFLLYSIVLDSKRDTLFFLIFTVFTQIV
LWITFPNVTIVLDNAQYAKRLFIIILSYVAVRYVTSEYDSKFQGYQRFSRGQEILEKIST
NFIAVNQDNVRAKIDEMFMMAAEILQYDQAYLFRFDDKGERATILNAYVRDSEDNSLLLQ
LGRSFKISEFPQVEPLAGKHSPIFCDDIANLGTHTQDESANFFLSRGINSFYALPIFVEE
KLSGFFVVEYKEKNELTVVESRLHYLKIIANVLGDARKKIIYEKQLYDFAYIDKSTNLPN
RNMLINNLEELLLNRDDADKLVVFNVELDNLRMINDTFGHATGEQVVIKSASILQTLMKD
GCVLSRIAEDKFIIVMPIAETIAQVMDCANEITDAFVNPILPADSIGSLFVTTIVGVATF
PEDGRDATPF
>A0A0L0H216|diguanylate cyclase|EC 2.7.7.65|Trabulsiella odontotermitis|TrEMBL
MDRPSWLKRLSRRKNPGRVVNLCFIIVLFFSTLLTWREIVVLEDAYISSQRNNLENVAHE
MDARLQFNVDRLLFFRNGVQSAISTPLAFEVLDNARGEFEQKRQAPAWNIALDKRRTLPV
YGVSDDFVNKTSILTRENTLLENEITATLELGYLLRLSHSTQRLAERMLYVSRGGFFLSS
DPKQNPQTIITTYYGLVTSPWFAMQSQRNNPGRGIRWNTLQEADSAATEAQKVTASVPID
VDQYWFGVLAMDFSVSEMKNFLLSAVEGEREGEYQLYDSRMHLIATSAGADDYPLRLTVR
EEAQLANDFGYDNRGGIRLVTSYISWEKLRNFDGVLLRIHRLHEGVRGDFGTITIALALV
WMLFTAMLLFSWWVIRRMVANMAGLQESLQWRAWYDALTRLYNRGALFERALDAVQECKQ
KQLPISVIQIDLDHFKRINDEYGHQAGDRVLSHAASLISSKIRDTDIAGRVGGEEFCVVL
PGASRETALEIAERIRNRINMREILVGKGATMRISASLGVSSSDENGHYDFELLQSVADR
RLYQAKQEGRNRVCASDTSTL
>A0A4Q2R4G6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp. 743-2DZ2F-22B|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLTDPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A649YVE4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MLDSLFKKLFVLSTTTLMLTLFIIISFAKVAGEQRETKAELDQIIDLQLCVDLLRSQLWV
FLQFGDESSLNQVELAQAELATKLTAYKQNNSQLGNIQRMNHSLNALLNKEKQVYFLSIN
GLDEQGSANINARGLLHSRYNMIVQNMTEELAYVHQSVLNRNANSLHQVMLYAAAWLIIC
SVLVSATAWLISFRFKSGAEAMKNAIIDLAEGKLDSKVEAVKMDTEFRIMAQFFNQMTMS
LCETTVTKQELEEEVMRQTQQLKHKQEQLIFLSEHDPLTNLVNRRAFDKALENAIVKANR
TQCKLAIFFIDLDDFKSVNDTFGHEAGDAILVEVASRITAAIRESDFVGRFGGDEFVICL
DLLHDFDIVAKKAEQLLDAINAPIEFNGRTLKVGASIGVSYFPDQTKNKEVLLSIADEAM
YRAKQMAGSACFDGKTTVCKKGSKSVRLTSIND
>A0A6N6K070|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MIRRTQEIDVILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDISGDDSHAVCQFGQWLKD
HPQHDDDECSYVSNIHATHEKMHLLGKELLLAIVEERSHSWHFDSFQDALLAFTSAVMDY
KIYLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDRVLRSLASNLLAWTRYDEVAYRYGGEEFIVIIRTKTDEQACQAGLRLCHLIGQKKIPY
PEGEIGITVTAGITRVQQGETLDNGLGRADRAMYEGKQTGRNRCMFMDEKEEITLVGTND
QLTPRVRA
>A0A649YXY9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MVDTQQCLTNPDAQLIDLSKWQEMVNLLADLFGAATGAIVQLRNDEFNVVVSSQNPDHYL
EAQMNWPWNMKSFCRHMVETRQDLYVPSAATHEVWSAAPPVAEGAVRSYCGIPIFWPNGK
PFGSICVIDTNATSYDKTLIRMLCQLARLVTLDLDTACRLQEAEELALKDDLTNTFNRRG
LTLLGEQKIKDAPRYQQAIGMLYIDIDNLKQVNDKGGHESGDQCILILAQTLREACRQSD
VIARLGGDEFVVLSLLNTRRELKQLAARVSAEYLAQTKDKESLSLTSLSIGSHIEDCFGA
PCLEDLIAQSDKAMYQNKQSKK
>A0A649YNF4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MLGFQMSVKLFSSQASLEQNVLKITSFFLAITGTGFTIVNFFFWDLPKFGVIDSIYTAIC
IYVYLRIEFGHYRPWHSALLISGLTALLIYSMAVADGYSVLVFWAFCFPALYHIFFNRYI
ASAITFAFYLVAISILASYPPLINSTPYTLINFTIPYFLIWAISFVHEDMQTKIKGKLSD
AALLDPLTGAKNRLALEADTSDNPDLVHNHYLVHFDLDHFKRVNDNYGHAAGDTVLKMVA
KIVGQQVRQDAFYRVGGEEFCTIFSAPDKESAFSIANALREKLSQTPISIGDQTLQVTLS
GGLCELVVEEGTVRIDETMKITDAALYQAKAQGRNQVIAI
>A0A6V8IDI9|diguanylate cyclase|EC 2.7.7.65|Gluconobacter sp. Gdi|TrEMBL
MTVDALLSNSQQLSPDEVEWQLIIDAIDPAIRSAVADMVEKHAAESVEVFYSTLLTHPEA
TPFLSNQIVNDHLHSALLRWLQSLFSSTAPDLAQLVATQRRIGLVHARMRVPMHVVMHGA
RLLKNTLRKLLFEIFLTPADLSTAIDYIENMMDLAIEMMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREVQRAALLDWGHKILLAICCNAPPPLPSLESSGFGLWLNHKGSLLFPNTM
GIEHIRTSMRRIDRVLIPALSAQVPPDTARIHELQAQIEEIRFLMDDLFKESEALESGRD
PLTSTLNRRFLPTIMAREVAQSMRREVPFSILMIDIDHFKSINDRYGHTGGDAVLRSVAE
KLISSCRTSDFIFRYGGEEFLIALVETDTKRAFQVAEHIRENVTHILTQPTGSSFSVTVS
IGVATFDGHPDYTHLIEDADRALYYAKAEGRNRSVIATDALATLPQLQ
>A0A1V5FHQ6|diguanylate cyclase|EC 2.7.7.65|candidate division BRC1 bacterium ADurb.BinA292|TrEMBL
MTDSDPLARNVEAGLRRVNAGRRLGVRRRRELAQHVHDKLQAILIDPGERIAGAETYGTA
GVPAGIPVVRFGYLADVLASAADRTRGPFDWLPREFYLAGDPAAVDPRPEDLLLARAIRH
AIERHKVDQLLHRSVERLHQTERNFRNLLERSADAMLVIGEDRRVLFANAAAGQLFKRDA
VQLIGQPFEHPLEANRSLEFHTRRHDGVEMVLEVVAAPTSWDEQPAWLATLRETTARTLA
VSMLLHEASRDALTGLWNRRILLERIEQEIGRAERGGHALSVAILDLDHFKRVNDTWGHG
TGDDVLQTMARILERCCRKADIAARWGGEEFALLMPETAREGALIVAERLRTETARTPMK
TRKGEGFRMTASLGVAQWRAGEDAAALMARADTQLYRAKESGRNLVCA
>A0A5C6E1P8|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MMMAGGLSLALVLLVIGIAIGLRLARRQSKTNAAMSQDERERMLQMLHELGAWTSEYSGN
VSQYQSRLGELSDAVRVDPAVHQAAPKVVSLLQQIMDSNSQLKSRLDAAERQLDKQTKQI
ESYLTEARTDGLTGLYNRRAFDQRLDELFAAFRKGGRSFVFVLVDIDHFKSFNDTHGHQV
GDQVLQQVAKTLRLELQESIMVARFGGEEFSVLMNGPLRIAAEKMNEVRKKMAALQIEIG
AKKLSVTISVGLTEPRDDLVVSPVVRRADEALYAAKNIGRNRVYYHDGKGAMLVGAPEVA
RG
>I6CPZ8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHIHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7W6HAM7|diguanylate cyclase|EC 2.7.7.65|Aurantimonas endophytica|TrEMBL
MTARILLVDDVELNLKLLDARLTAEYYQVVTATNGPDALRICQTETVDLVLLDVMMPEMD
GFEVCRRLKADPRTAHLPVVLITALDQASDRLTGLEAGADDFLTKPVRDLALFSRVRSLT
RLKFVTDELRRRAETAVSLMAADTHFRPDLLEPPPHVLLFSESAEHGQRVRRHLRGVASV
GIIDDVAGFGDAAAAGLADVLLIDMDGKGVDPLRLISQLRSNEASRLTPILASARPDDEE
KLARALELGGNDYIHRPIDRNELVARVRTQIRRKRYDDGLRNSVQRTIQLAVSDPLTGLH
NRRFLETHMARAVAAAQHNGVGFALLMADIDHFKRINDNWGHDAGDRVLKEFATRLSQCL
RSSDLACRFGGEEFAILMIEADANTAVGIAERIRQSVCERPFIVDGKAITVTVSEGLAVF
EPGSDDNLSLLKRADAALYAAKRAGRNRVEVRDAA
>G7ZDU7|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MLAIIGTVACVDMKRAWVLATIGLIGLLNGVLGALLAAEREAALRSMVDVAALATANNAK
HMDEVLEIVNRSMYMVSEFMRASERIAGLEDVDIHRLLVHQHRITPILRSMFVVSAEGHL
RYDSRSSSPARIDLSDRDYVHHHLSGNADILFIGRPVISRISGEWVVPVSRRIEDRFGRL
IGIIAAAIDPEVFFATLHASALPNGMQAAILSPSGYVFGCLPKSDCLGQPAADWPLFLQQ
SPAPGAVAASRRVSVMPDVVGPGAYEISPRYGMIAAAAIRTPDAIADWLSRLPAYFALDV
VLSGGGAVLSAILYRQVARRRRAMQDLAEANARLEQRVAERTAALRCSEQRLTTFLATAR
DAMLVMDGNGTVQFLNPAATALFGYPADDVIGRNVDMILPGLSNDPAALSGSGCFDTHGW
SRQGSGHELVARHRSGVEFPVELTLGRSDSDGEAIHVGVLRDIRERKLQEERLWELANLD
ALTGLLNRRAFMERGSALLEAGWRLGSPVSVLMIDADHFKAINDGFGHQAGDDVLRALAG
ILGSAVRSGDLLGRLGGEEFAIILPGTDVSGAEHVAERLLADVRGVRVPVPGSRRELTVT
VSIGISVSGRRCRLDDLLAAADRALYVAKSAGRDRQASAA
>A0A7W4YTT8|diguanylate cyclase|EC 2.7.7.65|Cupriavidus alkaliphilus|TrEMBL
MLQRFSGQAWQLLASRPHRFVVVAFSLSVVLLLLLLWRGLQLSQDREIETLRHMQAVRAQ
SMDALLQREAERLLSVRNFAQHLLQIHATAPGASDADLRATLAHRDQPAWPVPAHDAAAV
YGVSAAALRGVDGFARDEARLAADVIVARSLSHLLSAAPEGSGIRRRIAYVSRNGVLTAY
PSIPQQQVVPAVQRLAAAPYFRDSLPSRNPGRAVQWRIAPATVERGQVSLFLSVPVYAEG
DFRGVAMLELPQRSLDDQLSSAPFHQARSYLVDREGRLIGASTRNVRAGETLQAALSGPW
PAATLDAVFHADSGLLNGVGGASGAGGSDLMFRRLRQGGLALVDEIPVNQLWLASAVRLS
GVIGAGATALGILLCATLAVVHSLFRHYMARGEALRTLAETDALTGLANRRVFAARFAAE
PLPIAVVMLDIDHFKSINDRWGHASGDVVLRAVADALRSGVRKADLPARLGGEEFAVLLP
GTGVDDAAAVAGHLRQRLEGLRCEPAPDAGSTEPIRFTASFGVAGLAPGDHGNLDALLIA
ADRRLYQAKANGRNQVVAQ
>A0A4P6M348|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MKKNVLVRTNFLVCIVIVIGFVVTSVISYQSNQGIFRKDMESVSRLTSEDIYHQIDSIFT
KPINISLTMANDSLLKDFLEGEEQHIGDQEFIDTMRDYLNTYRDKYGYDSVFLASVKTKN
YYYYNGFDRILDEEDPENLWFYNFLKQEKDYGIQIDNDQVEGAGNEVTVFINCRITDQDG
AAMGVVGVGFRVDSLQSLLQTYEDDFGVNAYLVDESGNVEISGAYTRFEGDRSLFDTCAF
SELRDTILGSREGIQDLWYSSKKSDGYVVSRFIENLNWYLIIDNDTTLLNKRLALQLLRE
ILIVAATILLVLITITSVIRRYNKKIIDLTVATEKVHQAVFQEATEQLYENIYEIDITHN
RAASESTAGYFESLGSPPDIPFDEALRIIAQKQIKEEYREGYIHTFHPERVLEAFESGKE
NLQYDFMITSDGQTYYWMRITAHIFRWQEDGSVRMLVYRQNIDEQKRHELYMMEQMQRDS
LTGLYNKVAAQEHVRQMLEQRQERLYAFFILDIDHFKEVNDQLGHAAGDQVLVEFSRALA
GAFEKDAVVGRIGGDEFIGFLAVKDMAAAEEQAEKLLTALRRRTEEGVNITASIGVAVAK
GQGTDFETFYKKADFALYKAKKQGRSRYVTTTVD
>A0A2W1JFG4|diguanylate cyclase|EC 2.7.7.65|Acaryochloris thomasi RCC1774|TrEMBL
MKLFNPASLFTHLPYRGKELDEATDSENTDIRITRSLTTAYTVALSLIALLSIGAHLLLD
NVIKENVSSAKVINVAGRQRMLSQRISIYATALEQGNIDLKPEFLKLTTLMEQSHKALVY
GNGKLDLTHKLTPELRQLYFSEPDALDRRTRTFIKNTKILANSTDSNQRQEAYKKIQAAS
LKHLLPMLDEAVFLFESDTTERTMRLRNVQQAMLVILLMALSLEAAFIFRPMVHRVKEAT
FKLYNLAMHDALTELYNRRHFMETGRRELLLAQRRQQPATLLMIDIDHFKRINDTYGHAT
GDAVLKKFAIVLLQALRQTDIIGRIGGEEFAIILPDCDAPSSQSVAERIRATMAETRLRN
PSDLSWTVSIGIAILDEGTDNLDSLMQKADAALYRAKESGRNQVVIS
>A0A8F8G940|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MNTLTSSASSAIEPSSARFSSPDSAAPFSVLVVEDQAVMRAALVSELHQAGVTQVLEAEN
GRSALALFRSERPDLVLLDIRLPGEDGYWVARQLREAEPGEWTPIIFLSGLDNDLDVWRG
IEAGGDDYLVKPVKPIVLVAKLRAMRRLLDMRRRLVSVSAELHLANQKLNEMVELDALTG
IVNRRGLDRILHAEITAARREGKPLTLMLCDLDHFKRFNDTYGHVQGDECLRQVGRLLRE
VCVRPRDIAARYGGEEFALVLPNTPRSGAMTFARALGQMLKFLKFRPAGSDEEILLTLSG
GITTCIPDEHTSAESMLMRADEALYAAKSQGRNRFFSFEMQMDTIEQRQI
>A0A7U9RZW6|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MGTDRKIQIRGIKIRTLNVVMISISCILYVLLLWATVHALQKYDIMVSATEHANACQKNA
ALVSEGSDYLTEQVRLFTVTMDKQYLMNYFKEIYSTKRRDTVLDQLGDYDISSKTSDYLR
TALNESNELMQTEMYSMKLIAAANHYSMTNYSDVEQIDLTTEDAALSPKQMIEKAQDLVF
GSDYQNAKKSISRNITNFLDAILIDSRQKQQASTLNLKRTMRNQQILISILFIENILIFI
LIIRLIIKPLQIYINNIKHEKRLEITGSYEFKYLALTYNNIFELNAANELILRHQAEHDP
LTGIMNRGAFEQLKTAFKTYTDPFAFLIIDVDKFKLVNDGYGHETGDDVLKKVAKLLEKS
FRSTDYPARIGGDEFAVIVTNITPDMKTVILNKINAINETLMNPDDDLPQVSLSVGAALS
ECGFTDDLYKKADTALYEVKEHGRCGCRFFES
>K1L1B1|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MMSSIYSMDLLNLLFKNSNDAVFFMEKINGKYRYIFVNDAAVNLINTNPCGKTIEQVIPS
HLAKTIIHYYDLTIEQNRQVEFEDFTYGKMNVRKQRTTTIPVIQDGKNYILAMTKEVSMS
LDLEDKYLFMRSIFSNSFLSTILVSNDLQLLEANPTFLEEFNIQMEDASGISMLDMPFIE
RKTAKKLKSYINRARLGENVQSKMLFFIDKHNERRCFTASFSSLTSNGENIAVFIILQEI
TEFIKQGQALRTASHGLEMFKNAINSLADVIFTDVDGNIIDINERVIENTGYTHDELIGK
PHHILHSTYLSDSASMSFWQKVSKEEIWREEVCNRKKNGEIYWVDSTMIPLKNELGEVEQ
FLMVQYNISSEKQLMSELYIIERNFRAITENTNDFIVVTDRYGKIKYASPSYSRKLGYRE
EELIGLPYDRLLKPESVKLWHEALNPETVDVIQEQKIELLLYKKDNSTIWTEGNYTLTFA
LSHHEITEIVMVSREITERKELEDKLTYLAYHDSLTQLGNRRKLYKEFPLLKKEADETGT
CLAILYLDGDNFKEVNDIYGHDVGDEFLIQFGNSLVRSVRNEDLVIRLGGDEFLIVLTGL
SIFEKERSVQLVHIMDRIKENLQIGWLIRGSHFSPTASMGISIYPKHSISLDVLIDLADQ
ALYKAKQSSN
>A0A378WAE8|diguanylate cyclase|EC 2.7.7.65|Mycobacterium senegalense|TrEMBL
MAKTENWVSRAEFEFATGALRHGRFMGAFCLVTALSCFALAGLGIIVQFNPAGPTGVASR
SVQAAAVISGAVIGYRWLRRPWPQYEAAVAFVVWADVAVAAVATTMSTTEAQLSTTLYLG
MTGVFVGFLLGARPLAVHCAFGAVVITGITGWAVLLRPGSLWDLFPIYMPALMWVVVVPL
TGCILIERGRNAVVQVAQSAHRDQLTGLRNRRGMHAAVRRVVTGRTTPANLVVAVCDIDR
FKRLNDDEGHAAGDVALIAMAERLRSIARPGEIAARLGGDELVLVTMIDDPDGISELLDR
LDVLTRIEVGGRELSVSVGVASMAATEPHFSVDHVIRQADSAMYGVKRSGGGACAVHGRE
TDGTVQGFVAGT
>A0A498TXE1|diguanylate cyclase|EC 2.7.7.65|Bacillus safensis|TrEMBL
MDSIVLHFIVIMSVSGILSVILSIIAHANRHRYIGCQLFMYMSGATAIYIFGHTFELLAR
TPGEIMFWVCFQYIGLPFIAPLSLLIVLQFTGFHQYFTKRRVLLILLIPTLTTIMVFTNS
LHSLFYRSITMNPVDGFLLADFTIGYWYVIHGVYTFGCSMLAIFMLLWFLRVTKKEYLKQ
ILILLVGMSLPILTSFIYLLGVTPLHIDPVPVVMFLTNALYLWAIMSFQLFKISPIAMER
VFEHMSEGVLILDRYRTLIDYNPAAASIIPALANKKGIGYKIDDIFSAIIKDSAFIQWLR
SPQDHSQYDLMWKKEKDQSCYYHLTASSLFNRRGEIEGRQIVISDVTEQRLLQEELERRA
YIDGLTNIYNRSSFIERTQMILEEDAQDTAVMLFDIDFFKQINDTHGHHIGDEALRHVVS
ICQEHLQMDDLFGRYGGEEFAICLPHQSFKEACHIAEKIRHSFEASFFTNDEEKVRVTAS
FGIAHTANDPCVLETLLFEADQALYMSKRQGRNRIYASTGKGHVLYQEQDLPN
>A0A5E1ATE2|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MMNDENFYNKERIGEEWLQNLSQDDAHRTGIRFARRVRLGRIVGLAAMFFPVAGVLVTHF
LPGGWWLLLVSWVFIWPHLAWQFTCRSSQPYQCEIFNLKIDAIFTGIWIGLMGVNALPSA
ALVMMMGMNMMGSGGCRLFLAGIAITTLSAVVTLKLTGNVVVLSSGSLEWWLTLPVLMIY
PILFAWVSHQTAIRLAENKRRLELMSTRDGMTGVYNRRHWETLLRMEYEKCRRDHCQTTI
LLIDIDHFKSINDTWGHDVGDEAIIAITRQLQLTLRAGDYIGRFGGDEFAIIMSGTPAES
AIAAMSRVHERLKKLSLPCAPNERLRISVGVAPWGTQFAHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A484XQB6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MINDEIFYTKESVQEEWHQDLFQDDSHRSGILFARRVRLARTVGLAAMFFPIAGVLVSHF
LPGGWWLLLVGWAFIWPHLAWQLAFRSAAPYRREVYNLKVDAIIAGVWIGLMGIGALPSA
ALFMMIGMNMMGAGGFRLFLTGTILAVLSALITLHLTGNIITFAPGGLEWGLTLPVLILY
PMLFAWVSHQTAIRLAEHKRRLELMSSRDGMTGVYNRRHWENLLRNEYEQCRRSHREATI
LLIDIDHFKGINDTWGHDVGDEAIIAITRQLQMSLRAGDFFGRFGGDEFAVIMSGTPAES
AIAAMSRVHERLNHMTLPRAPGVRLRISVGVAPWRTQFGHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A518I601|diguanylate cyclase|EC 2.7.7.65|Gimesia fumaroli|TrEMBL
MISPEKIWSSDQLPTLPAVAVRLLDLSKNPDTDIKEVIETIKADPAITAKILKASNSSFF
GLRTECKGIERAVPLLGTMVVTSLALSFSLSESAITEGPLKSRFDSYWKQSIIQSAAAEL
LASKLGNELKYDSFLIGLLQDIGHLAMLRSIPNDLLPVLEQAEAQQRNNSEVETEVLGIN
HAEVGVKMMERWQMSEQFKSAIEHHHDSFEQLKALESDPNFKLIIIIATSASIGDYFCSP
NSGLALHRLQALTSEFYNMPHDDLHGFLENVQSRFEEAAQVFQVNMDDIGSPYEIMATAN
EQLVQLTMKAQVDSTQACARQAVIEEQKVKLESENKQLQSKAIHDPLTKAYNRSYFNEAF
EKEIHCCARSAQPIGIIFSDIDRFKQLNDTYGHQFGDLVLQRVAQVANESTRRSDVFCRY
GGEEFVIMVNNPSENGIKELAERLRALIENEVIEFEGQRVPVTASLGAVVGIPPRNITGF
AERLVAEADEAMYESKEKGRNQVHVRSIISQEDQELHRLIKRSRFSRWLVTKKVFDIPTI
SKALLKCPKQGEQVKIGELSIAEKLLTADQVVKILDLQKKTENRFGEVAVRNNFLTLDQI
AYLLALQIEPPIALGKTLITLELLDSTHTAELVKQYLSEIKDSAAPKEERQTEFVNS
>A0A1P8WI78|diguanylate cyclase|EC 2.7.7.65|Fuerstiella marisgermanici|TrEMBL
MQINTHGSRTLSVPTAFKTADKIMEFQQSTLTPESFVSGDACRVSANASMMDVFRKTADG
DYHFVLVEDDNGVPIGIVSADDVMRHVTNPSGSEFHRWLEMPVEAVLQSRIRIPDEAAPQ
DLDSGDCTRVTHDGHVLGVMTRRDVLLSWRSVQQTLRESRRDIVTDLPNRSSFDHHLKVE
CSRANRDGHSVAIVFVDLDYFKQINDQYGHAAGDSALKVVGGLLRETLRSYDMVARYGGD
EFAIVCCGCGVDEIDVVLRRIRNGVMSQQQTRIDRHKLPSISVGAAVQHYVSDNFSSVQL
IEAADECLYAAKRSGRNCAWKVELSAGQSGKPVLVPDSPSPSPLHQPAVALAR
>A0A679J814|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MLRRLADKISLRHQISLFAGAVGLSIVAASTLGSALLAREQATDMAQNALLQVARSVADR
LDQDMAERLREIRNVAALDPLQPHWMEGTGSLRKVLQTMQKTLPDYAWIGFADETGQVRA
ATGGILEGANVGQRPWFIDGMKGAVAEDVHVAALLQSLLKPSADKTPFRFVDFASPVTDA
SGRIIGVLGSHLSWSWADVVRREVLSSRRPELKEEIVVLDRTGRVLLGPALGTTPYSPAD
LAAGHFIASGPDGKRLAAVSATRGRGDYTGLGWIVVALQPVDTALAGAHRLTFLITLIGL
GAAAIGVLGIFLVVTRLSRPLTHLTDAVDRIGREPNATMTERVHGSPEVLRLSAAVRSLL
RRIGTAESDARDIENEASRAVQAAQDRVKRIGADLQALQLIANKDALTGLLNRRAFLPLA
KEALNDFKLHHRPIAVLMIDIDHFKRVNDRYGHPAGDVVIRKVGSIINDTIRTTDKVARF
GGEEFVVLLGDSSAVGAALIAERIRQSVASTVFEPDNNRLLATISIGIAEAEPSDRDIDR
TIERADRALYEAKSRGRNCIHTFTADIADLRSVA
>A0A5P3A7J4|diguanylate cyclase|EC 2.7.7.65|Roseovarius indicus|TrEMBL
MQLRLKHMRDVRVFAAAITAVALAGNFALQSLMYPADVVGGLRFSGSIITVALALPISFF
VGLRLRDIYRLTVSLEAARDRDPLTGALTRPAFHRCAAEMGGVPATLIVADIDHFKGFND
RLGHLAGDAALRHVVEVLGRNSRKEDLLARFGGEEFLMLLPGTTPGEGQRVAERLCARLR
NNPVLIDGAEHPVTASFGVTEVKTAQDLGAAIGRADAALYAAKRGGRDRVCKG
>A0A378JT58|diguanylate cyclase|EC 2.7.7.65|Legionella moravica|TrEMBL
MLIDNEISKQLNQRLVIECYKDYIFLVISDIAAAVIYFSVLWDYVSNRTVLIYWLVSEII
INDVIRIIFLWFYHNQLKNSKPQNLKFWNFYYIATSFVAGIFWAIGGLIFIYVDDPLHRC
IIFLVLIAILTAPALKMIAIKYAFIAFEVPIGIMLFLVSLSISPSVSLELFLGVIILLVL
LSYGSLSAHQTLRNSILKTLENNLLIDELKISEDNFRNIIENAPIGMAFLSLDGKYLDAN
HVVLELLGYTKEELSKLSYQQITHPDDLENSLHAVHKLINGETSVVRLEKRYIHKNGSII
TAISSGTIIHQYDNLKVFLTQIVDISDRVANEHKILDLNNKTISTLNELTLLEKNEKLVN
KLNGMLQLCITMDETYPRINLIAQELFSGFNGALSVLNKSNNSLETVIQWGKDKILRNIF
SPEDCFSIREGSITIIDDPETWVACPHYLNPPVGGYMVLPLFVQNDLLGVIHLSAQSAIP
IPKHLQDTALTFSNMVKIALSNIKLREKLREQSLRDALTGLYNRRYINEYLPNELAKMMR
EKSTLNVIMMDLDNFKKFNDNYGHEAGDEVLKLIGQIINQKFRVGDTACRFGGEEFLITM
VHIELNDCIQRLEEFQKAIKSKSVFFNNQILPVVTVSIGLAIAPRHGTSMDELIQAADQA
LYKAKMLGKNRIELYEPPGPRS
>A0A6N3R7R1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRTLKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A6N3R879|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MFLPIASTLVSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGM
WVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAP
LEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNE
FDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGD
EFAVIMSGTPAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKS
ADLALYKAKKAGRNRTEVAA
>A0A752MQ18|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 21:z4,z23:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6N3R238|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKSEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>K9NQ36|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MPRSSAVRFSHFLPSLLLLLAGLAAAYIKDLNVFFTSLFNVLPTLVLLLGGAYCAVYRRQ
RELFLMVTVYIAYFLLDTQTDYYRDNGKVRDDAAVVFHLCCLLLPLLFGVFAAWQERTHL
FQDMVARFAVLLAVGSVALGLEQSYPHALLIWLSEIRWPALHGAWMSLIQLSYPVFIAAF
VLLAWQYWRNPRPLHAAQLVGLLGLFWMLPKTFILPFTLNIMCSQVMLMIAAAVAHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMSDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKIGGGGKAYRYGGEEFALVFAGKTLEECMPHLEVIRESIATYNIQLRNQENRPQDDNQG
RQRRTGSGASSVSVTVSIGVAERIDQRTPEEVLKSADQALYGAKGAGRNCVMAFGQNRRG
AVRMDAATVE
>A0A8K1IS01|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MTNAESPVPNGTVLIADDERTLRMLMKRAVERDGYESVDVSNGQDCLDHCQLQLPDLILL
DAMMPKMGGFECCQRLKQQFSQNCPPILIITTLQDSNSIERAFEMGAEDFITKPIHWGVL
RQRIRRLIEAHRATQALQRSLAREHQLSQKLSLQVLEERRLASQLELTNRQLEAANARLE
ALANLDGLTQIANRRAFDEQLREQWQRGAEEQSYLSLLIADIDCFKPFNDTYGHQAGDDC
LRRVARVISDTICRPEDLVARYGGEEFVAVLPQTGREGALAVAQRTLEAVRRLRIPHKTS
QCSDRVTLSLGVASVIPDPEMTGDALLKCADRALYLAKTQGRDRVHVASETAMRSQTPKD
NLNCQ
>A0A8K1MQN3|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MFVSFFNYPFLQPSQLPSHIDLAIETPKNTQYVTNLKRWSRGCAYGVISLGILVLLGWLF
DIGLLKSIAPSWVTMKVNTAIGLLSAGSALLASHRRLKFWELTGTWIVLALGLLTMAQYI
FDINLGIDEVIFPDDPDPVATYAPGRMALNTAIAFSTLGISLGYQAYRRYRLAQFFAIVT
LMISFLGCLGYVFGITAFYGIGQFTEMALHTGLAFIVLSLGILGRYPDRGGMGITVSELA
GGATVRRLIGLTFILPTVGCGLVLWGKRAGFYDGEVGLVLLSVASVFVLGTVIWWNARTI
GATDYQALYDNLTGLPNRILFRQQLSNCLREAREQDQSLAVFFIDIDCFKKINDTLGHDI
GDEVLQLVTRRILAELPPPSQSLSLGRGRVYPPVAAFCRSAHL
>W7PBS6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLLASNADTAERQAVEQRQRFDQLTEDVETDAWAQS
DLARLYVIKKDPQTLKEYNQSENYLKNIEIRLEKLRDNGASDDELSLLREGIKIIDELQD
EQQTALASLERGEDAQAVALLYGQPYEQELDRAQNQIDHFRQILDKRVIGSVKDATKKSK
ALRTASELTVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAISIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYVLDREPWQMRCVAQWLSPVGEETTFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPASQAESALCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQTAQAIRTGVPLSCMMIDIDHFKSINDRFGHEA
GDLVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLSGADEAEAYACAQKIYTGVHELSLRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A8I1XNW9|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MSPGTLHRNSESAVLPQRVLLVENSRTFTSMLREAIEQRVELPVTVVSTLAEAARVLDEE
DGWFLVLTGLVLVDGDRDKVVEFFLSRKLPTVVVSGVYDEDLRQRVLQQQIIDYVLKNAP
GSIEYLAWLVQRLERNRRIAALVVDDSLSARTYAGALLSMYGYRVVLAADGAAGLDAIER
DPGIRLTIVDQEMPGMDGVEFTRRLRAIRSRDKVAVIGISGNSDSSLIPRFLKNGANDFL
RKPFSREEFFCRVSQNVDQLELIGTLQDLATRDFLTGLPNRRYFLEQSQRVIPKLLLQDQ
TVTAAMVDIDHFKHINDTWGHEAGDQALRAVAASVSGHARPQDLVARFGGEEFCLLVPGL
DAANATSYFETLRERISALRVRVGDETLSMTVSIGVCTASESDQSLRYLLNEADKHLYLA
KAGGRNQVRLAS
>W7PAZ8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDALQNAVSRFNTVRTLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDAERLSHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFVSTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDHYWYGVVAMDFTLSTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHAENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCIVLPGIGLEEARGVAERIRCRIDSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADARLYQAKQCGRNRVVWRD
>A0A6P2FXU0|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. PBL-E5|TrEMBL
MFEDRLQALSELADGVAASLDEAALRDKPRLQQRLAQLTLVAPHAFRTLSVTDLNGYPLA
WVPATTGPQADASVADRSYFSGVLATQSRVIVGPVLSRSLRTHVTIFSSPIYGAEGKVVG
VVVGSIENIALAATAGLGDFAGGPASLVTVASEEGTIIAQRNADRMGESVRTLGPMAKLF
TEAEAPSGLVYGMNADGVPSLMYVTTISGPSSPWRLVMEAPVSKIFTDEAELRWHFLVVL
SAGTALLPLLWLTIRAVLQPLRVLHRQVAAVSLGNTVPAMDTSGLHTSDELELAEAVRTI
SRASTKSLSVEEAETTRLRTALHNVDAGVLVVDCESRITTINQVAARLLGWRVSDALNRP
LDQVYQPRLRASGETMPSLHPALLSAKTALRRVNTLEAVSRDGKAVPLSEASVPVFLADG
STAGAVIVIRGPSAAEVPAVAGVHLRDETTGLRRHCELQSVLTKLFNANGPADGHHAVIT
MDMAGCGDQGPNLGQLRNAGKAVRETLRMGDRGFRWTEASLLLVLKNCDLPEAAFLAEDV
LGKLRASDAQTAPQVSVGVLAFGPGPATWTEVVQAATRVTDAARRQPGAVYIAPESNGAG
MLDALGDLFGQAPAA
>A0A4R0FUY7|diguanylate cyclase|EC 2.7.7.65|Enterobacter quasihormaechei|TrEMBL
MQHDTFVEKQSLLQWLHKRSNPGLIVNLCFIVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASALDRQLQFSVNKMLYFRHSMLDALETPLAFGVLQEAVKRFERVRRSPVWQIAVDP
KRTLPINGVSDAFVEQTTLLNRDDDYLDKEISAALEVGYLLRLASTNSRHEERILYVSRA
GFFLETDTPPHHSDIAQRYYHLVTQPWFTQQTDRENRARAVRWFISPPSAFAGKKPLITA
SVPVYYDHVWYGVVAMDFTFATMRQLLVEAMDDHTEGEYQLYDSRLNMLATTEKPADEVN
HFNELELAQIAHAIEQDTEGGIRLGSRFISWARLDHFDGLVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGALFEQAKRLA
KQCEQQSLPLSVIQIDLDCFKSINDRYGHQAGDKVLTHAAGLIASTLRANDIAGRVGGEE
FCVVLPGLTIEEAADVAEQIRERINSKEILIKKSTTLRVSASFGVSCAQEKGDYHFENLQ
SAADARLYEAKQRGRNRVVWQAHDKK
>A0A833PXA4|diguanylate cyclase|EC 2.7.7.65|Burkholderia gladioli|TrEMBL
MLITDTGATPVAPAEGLPAQAECGALLRLACAHFGVDAALVVGPGIDGPAALAAEGAWPA
ALPLDPFAPGPGQDSEPEAMVLMPEAGPACRLVGAADAHRPRLFAACALRDGDGARLGTL
FLLAPARRPLDGSEHAFLLDLAALAGPALARALASAAAAEARAAAPPRAGTVDTIDQELV
ALALNGSGTGIWDRDVASGEIRYSPEWKAILGYAPHELSSSIEDAVDRLHPDDREYVQAE
MHAHFEGRTDRYEVEHRILCKDGGYKWICSRGKVIARDGDGRALRMVGATTDITALRETA
ARLQQTIDLITNLTDEVDGLVFQYRETAAGDRFFSYASRGIQQIYELEPAQVAGSAALVE
ACIDPRDLAAYRHSLRESAALLTPWRLEFRVQLPRQGLRWRHGEARPQRQADGGTLWHGF
ITDTTERKRIEAELHELATIDHLTELANRRDFLAQSEAVFMRLRHTGHGEAAVLMLDLDH
FKSLNDRWGHALGDRALRHFAQLLRQEARSADIVGRIGGEEFAVVLPGLSIDAAIDYGLR
LQQRMTEAPLAVGERLVALTVSIGIDRMSAADLGVDQVLTRCDKALYVAKARGRNRIELY
TD
>A0A3E2YSJ1|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MW-13|TrEMBL
MPDPLTIASGISAAGALVSAWQLRRRALLAEAEIEHLQAELAAERHAASHDPLTGLPNRR
AFFRLAATLLTDAAGQPLIAVVLDLDNFKQVNDRYGHAAGDRVLISVAERLAAFAGDNLV
ARLGGDEFAGLLTSPTVDRRWIEHSSRRLCEALAAPIPLNGLSLRVTASVGLAPVTGPAQ
LTEALDRADAAMYRAKSVGASRPTRQLVDSAYLAEW
>A0A1H6FDS8|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MNKPSSTPHSEPPVLQTTMLPHHSQESSLSSTMHAPSRILVAEDSPVLLAIMLNTLATAY
GYQVETAENGQQALELFMLNPADMILMDADMPVLDGISACAQIRQLAEGRTVPIMIVTGY
GERDWVDRAYQAGATDYVMKPINWDVLRNRIEYMLKVKQAEEALLAEKEKAQVTLASIGD
GVITADAWQRVEYLNPVASQLTGWSNKEAIGKNLSVVFNIIDEDSKEKVYIPLPDELYLP
KVQDKHPQIILCNESQTKHFSVENTAAPIQDHKNRIIGMVLVFHDVTASRQMARDIEYQA
SHDPLTGLINRREFERRLNLMTQSVLEKETEHTLLYMDLDRFKVVNDTCTHAAGDELLRQ
VSKVIKKQIRYHDTAARLGGDEFGFLLEHCTLDNALPIAEKLCQAIQEIRFPWDRHVFTI
GASIGAVSVNFQHANMNRLLNMADEACVTAKDQGRNQVYVYQEKTKAQPGSGQWFLRLQE
SLEQDNFCLFQQTILPLNKKDQGLHYEVLLRMQDEAGQLILPGSFFSAADRYNLMPKLDR
WVIHYLCQWLHHHPEHLQKLNLVSINISDRSLSDEDFAEFVLEQLSRWNIPAQRLCFEFT
ELAASTHLLNTQHLLTKLHQAGCYFALDNFGIGISSFNTLKNLPVDFIKIQGSLIQQVMD
NPLNRSIVQSITHIAQILEMYTVAEFVENDPEMLKTLQEIGIDYVQGFALAEPEPLK
>A0A5E4S6F4|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MSHALPASRDVDTPHDSPHQGANEVTNAIAQTAHALWRTHGTTGSTSSHLPSDGRPGRID
AVTDIIDRESPLPTTRRDMTASEADHHASHAPASAPRHDPISGKPLDETERLAALRRYEI
LDTPPEPAFDRIVRLASYLFGAPMSLVSLIDESRQWFKARQGIDTPQTPRSMAFCAHAIL
GDDVFVVTDARADRRFADNPLVTGEPNIRFYAGAPLRTPEGHRLGTLCVMDRRPRTLDDE
KRALLADLSALVVDALELRRVNQVLGDMAMRDGLTGALNRRAFLMQAERLFCAARAQQRR
LSVLMLDIDHFKRINDTWGHAIGDRVIVELTQVLRTTLRKGTPIGRLGGEEFAVLLPEAD
AQRAMQAAERLLVAIGSASVPGPNGGSSGPVRFSASIGIGSLTPDDAEFGTLLQRADRAL
YAAKQSGRNRLAVM
>A0A735F375|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1P8PIL1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri|TrEMBL
MDNECMDMLAGQWQHICQNYSSDDLVHAFQFIKDNALILVEEFYKNMLVEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDEQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDEAKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGIQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A4D8PHF3|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALAEAEAISKVFYAILLDRPDSNTFL
SHTLVQERLRPSLARWITALFTASTDTAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISAKVSAAVEGGWVTPAFVKELNNDVTEIAYILGTIIEKAMEIEGGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRMVEEHRFHGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A0C7RA48|diguanylate cyclase|EC 2.7.7.65|Paeniclostridium sordellii|TrEMBL
MRHIEGDNFIKSIANILKETCGDKGIVFRWGGDEFISLLIDVDEDDCKKYVDKVNLVCKN
RYYKNLKVSISQGYSIFNEKSDIDKVLREADFMLYKDKKEPAK
>A0A1V5LMQ2|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin429|TrEMBL
MVVDAVVLEALAIAQRICRHISETPFVLDDGPTFSMTVSAGVALLDGTIRSVEDFAVVAD
RALYTAKANGRNRVEVFTPETSVPLPEPTPVEWEGDTPETPVGR
>A0A8E9YJN6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Inverness|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A447STU1|diguanylate cyclase|EC 2.7.7.65|Legionella sainthelensi|TrEMBL
MDFPGIKNEQIENKLIAESYKKFYVLIIADFFATLFYAAIIWPSINNKTPVVIWILVMFL
FNHVVRSLFLFQYHRRKKQDGLFHPAFWKKYFIVNNLQSGILWALGGSLFLYVEDPLHRM
AIFVYLIGLLGAPAAKLLTMHLAFISFIVPIWLLLVFLSVSITPSLSFVLLMATLLYVVT
VLYATTQVNQFLMRSIYLEIYSSNILSDLRHSEESFRNTIENAPIGMAIVSPDGKCIHTN
RTLQEILGYSDEELLNKNMLEITYLDDVAMTQDAMNKLLHGELRISHMEKRYIRKDGSII
WGMVSSSLIRNEQGEPINFIIQMKDVSDRIQNEEKMRQLNEKTMETLNELKLLEHDESLL
NKLNRSLQICITAEEAYPRINLIAQDLFPDLSGGLSIYNSVIKQMETEVQWGKEKLLPDK
FLPIDCFSIREATTHVVDDPHKSVPCAHYQIPPQGGYMALPLTVQNELIGVIHLWAPKDK
KLTQHQQDIANSFGNIVKLAIANINLRVSLSELSLHDPLTNLYNRRYLNEILSRELILIA
RENRTLCVAMLDIDNFKNFNDTYSHLAGDELLKVIGKLLKNSFRESDFSVRFGGEEFVVV
LLNITINNAVNKMEELREKIKNITIYFKGKPLNHITISIGVAEALKDGASIEEIIKAADH
ALYAAKQAGKDRVIAYTHNA
>A0A3S4JRX7|diguanylate cyclase|EC 2.7.7.65|Legionella sainthelensi|TrEMBL
MYNLYKRTDSEIVMDDNSISSSKFNKFLLYIIFIPALALVSGIGILSYHEVNKMLDANKW
VAHTYQVIQATDKILITIIDIDSELEAYLLSDDEQLMINIDKMKFDLKEDFDNLFNLIRD
NSSQTQRITHFHDLTIQRLKQLNQAIQLKINNKLNTPEEKDFFLQKQDLSNQIKGVAQEI
KSIELVLLKERNQVALNSAKTTNIAIIIGKIISFCGLIIAFALANRELSRSLRAEHHRKN
VESQLRSILEGATDMIAALDNQYRYMMFNEAYQREFKRLFGHSITIGMTLDDILTSAATS
AKKKLMEQWNDSLKSGELVRNIEFEVNKEPNVYEITSSLIKNENNEIHGTVHIIRNITKH
IQEQIELKESYKKLHAGMQALQDKNEQITLLVEMSDIMLACSSQEELSKVMTKYCQRILH
FASGYLYIMHPSKNYLEIATTWGKPNPQETTFLPTDCWAIRLGKMHQVSHSRDELICNHV
NTSSEQTLAFLCIPLMAQNDIYGLLYMEISEEPAVVFSQNQQLLITAFSELTALAFANVR
LRENLRYQSMRDPLTGLYNRRYLEDFLLKQIHQSERTKSPISLLMLDLDHFKKINDTYGH
DAGDVALKELGKILQEDIRVGDIAARYGGEEFIVAFYNTDEKTIKTRAESIREAVSRLQI
KYGAQPVGPITISIGVAVYPADGRTTTELIESADKALYFAKTNGKNRIVLYSEIENRKSS
VNKKNEYQNPSDDQLI
>A0A0M9GJK6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fuscovaginae|TrEMBL
MNDLELEEFKPTDENAAMVLLVDDQAMIGEAVRRGLATEANIDFHFCADPHQAIAHAIRI
KPTVILQDLVMPGLDGLSLVREYRNHPATKDIPIIVLSTKEDPLIKSAAFSAGANDYLVK
LPDTIELVARIRYHSRSYMMLLQRDAAYRALRLSQQQLLDTNLVLQRLMNSDGLTGLSNR
RHFDEYLELEWRRAQREQTQLSLLMIDVDYFKAYNDSFGHLEGDEALRRVAGAIREASSR
PSDLPARYGGEEFSLVLPNTSQGGARLVAEKLRQNVAALKIAHNTPSEGSVLTISIGLAT
LVPQQGGNCRELILTADKGLYLAKHSGRNQVGIGQP
>A0A554X323|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MPQPSTGLRTPRKLRNTVVLTVGVFALAFPLLVLAGFAWLYYPERLETAHSYVQERNRAI
SAFVEGYFREIRNTVQLLGAMPAVASAPWAPETVRQDVLRLYREAQRANPNIYYVYSGYT
DGTLLINDYTPPPGFDPRVRPWYRAVMDARGGRQEVVGLLYAEATTGELLLATARLLTGP
DRSATGVLSIDSHTREIAAQIEARSHIFASAQSFLIDSTHTIVAHANHALIGKSVRQVWG
DDPRIGPHGEIAYTDGTQRRIGYISEIPMAAWRLVTTVDEAEIRAPILQRLAVLAGMLFA
SSLAMTLVLAVLWQRRVMRPLALLLQRLRALSATGSAEGLAAQADDGMAQIAAAIESTLM
QTLLARNAQLDQANQQISALNQTLAQRNVELARQATLDGLTGIPNRRTIDAHLVAEHQRF
QRHGTPFSVIMFDIDHFKAVNDVFGHQAGDDVLRELARIVSQRIRTTDVVGRWGGEEFLI
VVRNGTLAEAQELAEQLRARVAAHAFPIDRPVTISLGVAQVLPHESIEHLVGRADAALYQ
AKHGGRNQVCAAPSPAA
>A0A7T0DT13|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MQRDTYFVKRSFLQWLHNRSNPGLIVNICFLVVLIFSTLLTWREVVVLEGAYVSSQRNHL
ETVASALDRQLQFSVDKLLFFRKSMGEALQTPLGFDVLQMAVARFKTVRNTPSWQLIVDK
DRTLPVNGVSDEFVSKTTLLNRDDEHISHEISAALEVGYLLRLASSSTQKEERAMYISRA
GLWVATNTPVNDDEIISRYYHFVTRPWFTQQSGRANRARAVRWFFSSTTSTAPADAPTIT
ASVPVYFNNYWYGVVALDFSVATMKRLLKDAVADHTEGEYQLYDTRLNLIASSEASASKI
NLFDDVERAQIASAIAGDTEGGLRLGSRFVSWERLDHFNGVVLRVHTLDEGVRGDFGSIS
IVLALLWALFTAMLLISWLVIRRMVRNMYTLQNSLQWQAWHDPLTRLNNRGALFERAKQL
AETCQQQSLPFSVIQIDLDHFKNINDLFGHQAGDKVLSHAAGLIATGLRTSDVAGRVGGE
EFCVVLPGIALPEASAVAERIRSRIDSKEILVKKNTTIRISASFGVSCAHEKGNYNFEQL
QSIADTRLYQAKQYGRNRVVWRDRDKE
>A0A0Q0GF35|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MIKHLLKQSKQSGLEEIEHVKFLIISKIAYFALIVHVLLIPVFAHIGANTLALVNILSVL
AWASGIFLIKQGLTSLALRVFCLEVIIHAVIVCATLGLGAGFQFYLWTVSCILMIDYQLT
FKRAALYSLVMIAIFALLYVFFSDVQYSFAYPELLPHVNVINIIIAGLPMVYGMGLIREI
TLSQRVELTEMAARDPLTKLYNRRFAKKLITAAHQKSIEQESSLCIVMADIDKFKSINDN
YGHEKGDTVLVNVARLIRQFIDDEDIAVRWGGEEFLILLTNTDAKQAFTKIETLRLRIAE
LEAHHEFPDLNVTMSFGLIEWQPLASIEKMLQHADEALYKSKHAGRNQTTIAKGHRPAFK
DADAVN
>A0A0Q0I4F5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MNKQASPPEVKAELNSVPLIIKRLFISSFIVFLLLIVITYLYYFNRLENDIYLNGVLSDA
INLLILICIFAFVQTSVVAKRSYLFLSVGIFLWSAGLTFDFLDELVFQPIWVGIYIEDIT
RTLGMLVTGFGLYLALTDLAKTREQLEEELKTDVLTKAYNRRYFYHYVQQNQDKPHSIVI
ADIDHFKAINDEYGHDVGDQVLIDFVYQCHQALDEDILFARIGGEEFALYVATDDADELR
ATCEQLLSLANNVMVTPSKTLSVSVGSAIKRATETFSNTMKRADQALYLAKNQGRSRYIH
KP
>A0A0U1KFF4|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MSRSMISTKIFRLDLGRLILILAVMSAFVTLANSFYASYKVQRQLLIDNTLEANRVYATK
LASSTEIFLKSAQKQLYYSSMIAAQHFDDPIILQAETARLKYQTDSFNSVVITDAHGVIR
ATSPDSLQLLGHVLTSPGSTEALKLRRPLISKPYVSAANNLVVNISTPIITSDGRYRGYI
GGTIYLRKQSALNELLGEHYYRDGSYIVVLDSDRRILYHRDASRVGEILPPKPLTEAVKN
ATNGSLMVISSGGESMLAGYAVVEPSGWEVITLRPEASTLKPLEGLMIKGLGHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIAMSIKEIPSWYFESTQLKRALLIGISLLQ
KKIGKLKFEAQTDPMTGLYNRRGLATTLEPIAQLGQSFSVIALDIDHFKLINDTYGHDVG
DEVIKRLATQIRDSSRDTDILCRSGGEEFLMLLPGTTLDVAIQVANRLRHNVEMMEIANI
LPITISLGVAYWSGEGMPEDALKLADEALYRAKQRGRNRVEIG
>A0A380AXQ1|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MAAIMQVEFYPYSSQASGSKMHTTELPDATKLRLALIVFLLVFCTCILGIESRPIGLLAL
FWPTNAVLLAVLVRYPAMGSPVGWLMAMSGYLAADLITGSPLGKAILLNGANIAGVAVGF
YLFMRLSPQVRTLERTSSSIYLFAICLASATATALLGAGASVLLFGRQYLPSLALWLSSE
FTNYITLMPFILAFPRDWKGYLRSIFQAVTLRSQWPNTVRKIAVLLLLLLACFGSILIGG
PGAVIFPMPILLWLAMSFSLFSTMIAVLVYVLWCHLAIDLGLITTNLDMKMLQNTVSMRL
GVALLALGPIAVASMNFARNALLQRLEHVANHDALTHVLTRSAFMQRGTRLVSQKGERIC
IMMLDIDYFKSINDRFGHAGGDAALLSFTRAITGDLRDNDLFGRMGGEEFAIVAPIAQQQ
DALSLAERLRHRVEIESINMPAGAALQITVSIGMVTCIGGSGQNLDNLLKIADLAVYKAK
NSGRNRVATPELLPHHSTEI
>A0A557RTI8|diguanylate cyclase|EC 2.7.7.65|Denitromonas halophilus|TrEMBL
MSEVLIGEWQALHDETPLPVRERLAAFIESRAGELAEYFYSQMLTDPATGFYLSHKQVED
RLKPSMALWLRRIFDASPDTDIEALFALQRHVGEVHARIGVPVEFVARGARRLVNRIIVE
YGDVLTERAEWAEAARFVSDSIGIPLEVMASAYTGSYRSRCPLR
>D4BDE4|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae ATCC 29220|TrEMBL
MEQVDPVNDTLLLTEWQALLRQTPPEVHTVLTSLSDEELRHLVNVFYDYMLSHAESALFL
NTEQVSARLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYSPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNGNLL
KEMEALIAEIDNRLTTTLSHQHLATDPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDRSQASIILETLRMKIADLRMAASATEAFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A1C3IKV3|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MKQQFLLEGHRAVNSLLRKLALGLDRKELNRKIIQLTEQIFGQRMASILLLNPESNTLHL
EYAPNLPDFYNQQIEGVGVGAGIGSCGEAAALKKAVMVSNINAHPNWTPFLALTNQANLH
ACWSVPIISSHGHVLGTFAIYSQYISEPHEFELEILELLASLYSVALEKYELENQLNFFA
NRDSLTHSLNRRALQREAEQVLTNRCFTEKVMACLFVDVDKFKSINDTFGHSFGDDVLLA
VAKVLDEATTACAKIGRYGGDEFVVFSCFDDQESVLNFYRSLERTLEQALYIDGTQFSVS
VGLSYDKDPESLEGLIAQADKNMYQIKQAKSSQ
>A0A859TRD4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVTPVNDTLLLTEWQALLRQTPPEVHAILTSLSDKEIRHLVTVFYDYMLSHAESALFL
NTEQVSARLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPGYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESAIAEIDGRLTQTLLNLQQPAEAARMSLLQDVRQLSTKIHFLLSSMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQANIILDTLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A5I6PHE9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Glostrup|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A381GLY0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MKIVQDKLRNRQALLVSGLITLIFTSLFLLIIYEQRIAAVSDGVNRMQARMMDIFNDNEL
IADAIGERYHHIKTGEQCGDISQFVPRNEIEWGINADPKRLHSATGTIIAQQASHNALCM
YTAAEFIRDMVNELNPGSFDAHRYIIAKNSDYFYWFMASDSRNFSFSNSEMARDLTNFFY
PPVDFYTRLLQKNVKNKALSSTNFYTDKITGEKAYSVVSYIYDLSGKEISDQIVAYLVYD
HSKPELQEALAQAFDHQIPPALNVALVNLTDNESLCLSGRCTGQSRFLVRNFSEKYALHY
SLSLGRFMTRDTHAGIVILLAPFFFIIITFSLKSWLNESDLKVYIDTLTGCFNRRILDII
KRRDLSHCSVVLLDCNKFKAVNDTWGHAAGDRALQIIANRMLSNTRTSHDIVIRTGGDEF
MILLFRSQATDAIAIAQRISGQVTSHVFVVDGHTVPLSVSWGIAEVNGELDVGYSEGR
>A0A7W3D3U1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGIWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7W3F236|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSFTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLYSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GDVIEDQAFQAGLVDPTLSQALDRRVFGEFFQNAAPAVASKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPASVIKTNPTQAESTLHRLRQYGCRIVLSQVGRDLDLFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A7Z3M708|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVEVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A8G0WJ31|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MFRLSAVRLSHFLPSACLLVSGLAAAYVRDLNVFFTSLFNVLPTLVLLLGGAYCTVYRRQ
RELFLMLTVYIAYFLLDTQTDFYRDNGRVREDAAVVFHLVCLLLPLMFALYGAWQERTHL
FQDLVARFAVLLAVGSVALGLEQSFPQALLGWLAEIRWPSLHGHWMSLIQLAYPVFFIAF
VVLVVQYLREPRPLHAAQVIGLIGIFWMLPKTFILPFTLNIMCSQVMLMIAAAVSHEAYQ
MAFRDELTGLPGRRALNERMQRLGRSYVLAMTDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKVTGGGRAYRYGGEEFALVFAGKSIEECMPHLEAVREMIANYNIQLRNQDNRPQDDQQG
RQRRGASAATSVSVTISIGASERLIDHRSPDEVLKSADQALYSAKGAGRNCVMAYGHQAK
RGAVRTA
>A0A2H9UNY8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5347|TrEMBL
MNNECMAMLAEQWRQICQNYSADDLLHAFHFVQEHSVILVEEFYKNMLLEKESAQFLTDQ
MVQQRLRNTLIQWLSESFSVPINKSYAQAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
VFELLQASSQNSMLTACSYIVQIMGFATEIMCRSYEAKTAVNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSSPDNLKHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDAINQTIMDCTDKNNVLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTVISREITFSRKNHTPLSLLAMDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDKQRALSIAESIRKYVENGMIKTAQGQQFKITISIGCTL
YDGYPDYQRFLDAADAALYMAKNTGRNRVYMAQSPSNPVGQQ
>A0A239SKL1|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MKRKLLSAISLTGRLRLQNLAIVCAVVMLCSGLLCLAWGTYRRASDAAIALDALRATLLA
MEKASAERGPANAVLGADLPLPASSVTALRNAREATNERLEELLSALSSDACNQCASGLR
AVERARLDLAAASANVDLLVQRPREMRSDASVRDAVERMVRVIADFTPVASSRIDIVSRG
APGALHYVILARLAADLREHAGQLGSHFTAALTTRQTLTEADQRAIERTLGRIDQLRDMI
GARVNEPPELGPDSLSALNAQYFGTGLHYVATVRTLAAQPNPPALTTAEFARQYVPTMRA
ITDLRDTMLRLAQRKVELQRSRALRWLILTSLAEAVLVFVIIVAMRNFRRTVVLPFESAT
RFVDDLAQGNLDATVPVEGIPMKREQVRAVFDALRALRLNAVELVQLRRERARLVGELEM
SSDTDPLTRLMNWRAFERQAQALCAMRTPGHIALIKFDIDNFTQLNAAWGHSVGDDVLRR
VGAVCLNTCQPGDVVARLGADAFVILARVLDESRARQFAELLRGRIEATTLALPNGEALT
LTASFGIAMADPATFEVIDRRTGAPTSVSALLSQAERQLHAARQAKRHAID
>A0A840XX82|diguanylate cyclase|EC 2.7.7.65|Roseomonas alkaliterrae|TrEMBL
MTARVLVVDDIPANLRLLEAKLRAEYFEVALAASGPEALALATAWSPDVVLLDVMMPGMD
GYEVCRRLKGQEGTAHIPVVMVTALTEQAERVRGLEAGADDFISKPVDTTLLFARLRALL
RVKQVLDAWRQRAETAKELGFESAGAPEEEFIGARVLLAGGDDAEAAVVAEALSADGILL
EQAPDETAAWERLQAMLHDLVLVSLPLAGGDALRLSSRLRAHGESRDLPLVLLAAEDQRA
GVLRAFELGASDHVMRPVDPPELRARVRNQLRRRRYQDLLRESLDRSLEMAVTDALTGLR
NRPYIRRHLDSLLRSGTAAAVLLMDVDRFKPLNDRYGHAAGDAALKEVAARLREQLRAVD
VVGRYGGEEFMVVMSGATEEEATAVADRLRAAIADAPFDVGPVTLPVTMSIGVAVSGGQT
AADGLIAAADAALYRAKEGGRNRVEAARPEDWQAGAA
>A0A8F7LES5|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MTDSLATGLDFEDMFNLAPVSLWMEDYSELKRLFDQWRAEGITDLLAFLQADTSRLARCS
AAFKVLRVNQYTLELFQAPDQATLQSRLGEVFRDAMLDKLMPELLALWDGQMRFENRSIN
YDLRGNPLNVQIRGQILPGYEHCWSRVLVSLEDITAEVRSTEQLQRSEHYARDLFEYSPV
SLWVEDFREVKRLLDEVRSRGISDFKTFLKVHPEFVTRCMQEIRVIDVNQQTLKMFGAHS
KHELMQNLRQIFRGEMYNSFAEQLQDLWDGKLVQQREVVNYALSGDLLHIHLEFSVMSSH
ASDWGLVLLSLVDITARKKAEAYLEYLGKHDVLTQLRNRAFYSEELNRLTRKGPWPVSVI
ALDMNGLKAINDEHGHAAGDAMLRRIGEVLSKAVDAPDCAARIGGDEFMVLMPGTDERGV
QAMQERIASLLELNNQFYAGQPIHMAMGSTTGHEGTPIENVVHRADQAMYAEKVRFYQSR
THFFQSSEHDRRIPPSSEG
>A0A2T0AQS2|diguanylate cyclase|EC 2.7.7.65|Clostridium thermopalmarium DSM 5974|TrEMBL
MNLIKSELQIALKNAFAQNKLKYLANFDELTGVMNRRRFNKELSFQIEKAKQERRTFCLV
MIDLDNFKKINDTYGHNFGDKVLRFFSYLLESSMERSGIIARLSGDEFAILFLNCPMDEA
KKKMTKITEIVASHKINGVTISFSYGICEVEGCNSITCTEALILADVDMYNNKKLKKLKG
SLNDKRIT
>A0A5I0D507|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ouagadougou|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2K9K2D9|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MDTFAKVELTQDLVESSFPLADLNTLLTSLSDYFEVPITLVTVIEGQWQHLIARHGILAD
RTPEQDAFCKSLIKHNRSLLVPDTALDENYANNPLVTGEPYIRSYLGVPFRLDGKPIGGV
CLIDTKPKNYAERDVHLLETISGLITNILELQKNYSLYLEDQELIRFSPIVLIKWKYNNG
LRIRTVSPNIERVIGIDAFHLCSGELHFEDLLTEPSVEKFHFNLQNHLDGLEASEILLEM
ALDSKQIWIRMITVAHFNHDGRMTSIQAFITENTAQKYTEDKLNETNRQMRLLLEASELG
TWDWNIPADINKVNKKWCDMLGIEFEYVETSVNYFRQLIHPADRSHVERDLAKHLQGLTD
AYTTSYRMKHADGHWVWIETYGKVVERDNSGRALRLAGTHRDITYRMEAQLQERKQKQLL
SFISKAQSAYLKTGDLSKSCREILEELIDIADSQFALIGELEHTAGVPRLFIHAISEMQW
NDLSSQLVQRYYDNDLYFTDFNNLFGSVILTGKTVISNERGKHPASKGTPKGHPRISKFL
GLPIKLNGELVGMIGLANKFFDYTEEDAKFLQPLVDSLAGLYYAVKLDKERQEAENKLLE
LAMTDTLSGLPNRRAFMEKAAEVGEISFPYLIGMVDIDNFKSINDTYGHDAGDKAIKLIA
YTIKDALRSDDFTARMGGEEFAFVLLDATHGSSSALIETIRESISNLEITLSEKEKIHLT
VSIGVKAVLPEMEKMSITGHLNDADKALYEAKHTGKNKVVWFE
>A0A173T5C0|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKKNQTQIKKYAAVISIFLAAVIVGLFVFFFCIKRSVEQRSKNTMRNNVVRQSEHLRTIL
DIQYDYLNGLTEEIGKTDHLLAKKNMDLIKSITKHTDFCGTALIEPNGDAHYDNGLIKNL
SHRRYFKEVISGKRTLSDPLDSSISGSTRVVLGVPIYNSKHKVIGALGGSYDVTALSRML
FEDLFNGQGCSMIIAQNGEIIAFEGDTSYWNLDYRDNFYKCCCKWIIKDKVTVKKIKQDF
KEGKENLVTADSKKEGTRRHYFAYMPMGANGWMLCYALPEQAAQQSYNFIEDYEISFMIV
FIVLVTLLILYIVYENHTRNKELLKYAQTDALTGLYNKETTEQLTDELLSEDENKYHAFL
ILDVDCFKQINDIYGHAVGDIVLQKFGKLLKGTFREGDILGRIGGDEFGVIMKNIQTKDI
AMKKAEELLAKTQAYKIDELKGNNISISIGISTAPQDGDCYMDLYKRADQALYQAKRSGK
ARVCNYFS
>A0A060UXN7|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus ferrivorans|TrEMBL
MNLKIIPKIPAFLTRPITMPPYRQTIFLVFYGTFVGVLVFSGWYAWFSWHRYEQDSEYRL
TLESDMVAAVTQKLLDGHASGLQFLGVQLQRADALQHPRRARTLLLDYQKASSETASANL
IAPNGQVIASTAIPAGKPLPDFRNNPAIWQGFQKVLQTHGMRVYHPLRGPLVGNHWVIRL
SRTVFSQAGQPLFVVATPLRFRGIGGFLSHLPLRTGTAVGLIRSDFYIEGRWPVPQNNLS
KMLAHPVSAEGALRQALQRDPHARHGTYAGTVAVGDHTYRFGAFTRLSHYPLTAFVSVPR
DQWLAAWWRRHIQFPLIFLIIALGFSLAAYRRILGDDLNRQNILRRERETNIFNEALLNT
QSSGVTVTRFPEGILERVNARMLEMFGASSQEEFLGHPIREFYLNEETYDQVTVAKQKSL
SEGHVALRDMPYRRLDGEIIYIDISIQRMDDTDGVQRVLGTLVDVTERHRLVDELARQSF
SDMLTGLPNRRALDAEIIKALARSARQEQLLAVGFLDLDVFKPINDTYGHDAGDDLLKEM
ARRLQDAVRRLDTVARMGGDEFVLLLEGLRSMDEVDQVLARIHAAIAQPFNVKGKMVSIQ
ASLGLTLYPFDEVDADLLLRHADQAMYAAKKRASRTQEGWVQLYHPDLGTITMGDETLRR
DFLRALASGAVTLRYQPLVALATGRVAGLEALTRWNREGQEVSPDRFLPSLGVRECQALG
RFVLQTGLRQLAQWRDMGLDLFLSVNVTPEELNQPGFADSVFGILAANPGIPPEFLVLEV
LEIGEILEQGVALEHLQRLRAAGVKIALDDVGSAYASLLRLKNLPIDEIKIDQGFIRELS
NKPQDLIFVESLVNLGLAMGVLITVEGVETEAHIALLREIDVDYLQGYAIARPLPAEAVA
DFVRTFVLGTGDTNTPLLALYQHMGWVHAAEESAMNHQGYEHAELAACPITTWLHAHASE
LSEVETLLAEHETVHALSLEILQVRQGGTREDLHRLLNQLHAHNHLFQEGLGQAVKTMRE
NAEANQ
>A0A8E7QFY5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQERKKK
>A0A755X926|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGVALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y8G3Y6|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>W8UJJ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30684/NJST258_2|TrEMBL
MRLRNILSARPYYPQERKLALVTHRRCRCLLCGILPMPEHVHHIVKRLILYICICLLAGI
GISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIACFMGMKYWSSKRRLYLTPVSFGFA
CSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFFRNIMMAVLFMSSIILYYFRQRIMH
SWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVNFIDDLSHTFTPLWQSIIGWLLMAV
WFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLSTAGELDQTWYQARFFETLCTLF
LILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHPLSV
LISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEKE
AQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNSVTAEACVQRADEAMYEAKNNGRNQ
VIVWHQQGG
>A0A379QNQ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFETINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDILLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMRS
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDLDSGKGIIINQSKNNLFQYVSYNHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLHIIAPDKTVHFSAGIYNMRPNDTINDAYQA
SDAQLYLNKQQKQHRS
>A0A6L5BQQ7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MKSPSQTNAIDFDSAKLQRLGFGQQPPILERPVSLAQLRQQLGLQLQTSLEPQRILGLFF
REIQRLVPLDALSYEHKTSDLRLEFGQRGHHTVSYSLSHEGEHLGELVFRRNQRFNEQEQ
GNLESLLSALLYPMRNALLYRAATQSALRDPLTGTGNRVAMDQTLQREIEMSRRHLQPLS
LLMLDIDHFKRVNDSHGHSAGDEVLKAVAASIKGQLRNVDMVFRFGGEEFLILLSNTTRE
AAAMVGERLRFAAQAQEYCADGQVIELTVSLGCSTLLPGESAESLLRRADSALYVAKREG
RNRLAMAG
>A0A0L6ZB38|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MSKIRQTFIIIIIVFTAGFYFNLKKQYSINDFTNSAISTENRVNQYIKLSCDYIDILSIY
GNEYMTSNTHDTNSYLKDLNYNKSNNYYSLDSASVKGYSNYVGNLTGKGYIPIDSESIKE
LNLALNYNKYFYSIYKTLPGITWIYYTSKKGFMNIYPWISSKEFVYNDVLLEKEFFIGGL
PNVNKNKSHFWTPIYNDAAGQGNMVTISKSIYNNQNFLGVVSIDITVNKLNYILQSKYNA
FLLNEYNQIIGSNFDNHEMETKLLNLNDLLSEYTESQLKALKDLPKDKVAKWQDNYIYKL
SFKDAPWALYCILPVDKVLIETFISTLPIFIIGAFLLLLSYEIYVRKKTETNLKGLVKEL
ALTQSLLHKSASYDFLTSLLNRRGFFEKFSELLAKTNNKELISIIITDIDFFKRINDIYG
HSIGDTVLVNVAHIIKNSINCNDIIARWGGEEFLIVLHNTKYEEAINKAEILRTSIANTI
IKHKEVEIKLSMTFGVSKYDDSIGIEQCISNADKALYYGKNNGRNRVDGYEDLFK
>A0A0L6ZEE5|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MYNILFSVLNSINEGVVILNENLEILFWNHYMEYLTGINKENAINNNVYKILTRLEKSYF
KVALDSTIKDGRKMFFSAAMHKNLVNDKQRLNLKISKIDNEKISVVLLEFIDVTNQFERI
DQLKNYIDELHILNEELKEKEKTINRLAYYDGLTGLANRTLFYKIADKFISEARRNKSLL
GLMFIDVDKFKSINDTYGHKRGDEVIIQVSKILSNSVRESDTICRFGGDEFVILLPFIKS
YDDCKEIVSRIINEKEKIINSENDSINIGLSIGISFYPKDGSIVDELISKADKAMYVAKS
KGGNNHYFFE
>A0A238LDT6|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MNLPKRLFWTTFGTGAIAVVTIVSLLVWITSMTDELARIEAQRLVETTIEIRTEQNALVT
EDYGQWTAAWEWYRDGDDEALYENLGSGAGDAETFDFLYFLAADGRPTHAYATDTYESDL
GLYDASVGAAALQAFGMPRLIPYHMTSGLVDADGRIAMIAVGRIQPDNIDGLTSNDMPII
IGGKWLRPDAIGSALMIDGMDLQPISETAAEDSAGLLLTSINDVPLARLTWPAPRPGRAL
LRHVAPAVGLLVLLIVIVSWTIGRISSQRTEAFMREKVSARTDPVTGLLNRTGLLEETES
ENVQESFAEGRIALIYIDLNGLKQLNDGHGHRVGDAAIKATAQRLRAAVRKSDRVARMGG
DEFVCLILDDSPQIAAKHVAERIALLTTPDFTYEKQSYKARVAIGIAFSSQAKNWDTLLS
NADEAMYQAKRGNLSNPVVFKSSIALAI
>A0A5B9QN90|diguanylate cyclase|EC 2.7.7.65|Bythopirellula goksoeyrii|TrEMBL
MEPCSFLPSNTTLSLGACVLNIPENCVLAMNDQLRLWMGEQCDSTSLGQISDLFPDLDFT
EITSSIVAPQSFTRKSILQRCGEPPIPATILLSPLASGQQTWHLLLVQPCEQSSQVASYT
DVVTGLPDRRALEDWRQQWRVKNPGAPCPHALLFLDLDDFKQINDKHGHACGDRILAILA
KRWQNSLRSEDLVVRYGGDEFVILLPGLRTAEEAVPVIQRLKARTAAPLEVEQNSFSVSV
SIGLALAADIEVALEDLLATADHDMYVQKQADN
>A0A846UCA7|diguanylate cyclase|EC 2.7.7.65|Rhizobacter sp. SG703|TrEMBL
MSARVLIVEDNAINRELMDYLLRAFGFETMKAADGAVGLEIARRERPDLILCDIQMPVLD
GPGFAREAKADPVLHGTPLVAVTAFAMVGDRDRLLALGFDGYIAKPLEPLAFIQAVNASL
PAALRANGPAQPPPAYTSLPPSGMTVLVLDDSQVNLQLKRDLLQPHGYTVVTADTPAQAL
RLAREHRPALIISDVGMSEGSGFDFIRDVKADAQLRDIPFIFLSSTHWNEASRTLGLQLG
AFRYLLRPLEPQVLLAEIEACLPQH
>A0A2S5D102|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MDLQEFEELWITLNELYSANRYLEYIELSSPAIESANALALYDKAMHLLRYSCMSYYQVG
DLQISINLLEKYRELTFLYGNDIDVIQYYSLASIYWGTFGQQKKSEELLMKGLEIAERIQ
HIESMGKIYNNLSGLEIELGKYAKAKRLALKSLFYTNEFDLKHDSPYKGIIHAKTNLAIA
HIWLEEFEEANMLLQELLSTIKDPPYNKAQLEVFNAQALLYEKQGRIGEAIDMYQKSKHY
ALQNNDLSLLQTIYNSLVKLIEEQGNKIILSAVQKEYINILLEIQRENYTQVLFEMEYND
QKKHFERTSYIDPLTNIYNRRFFDEQAKEMVKNAASNQKLLALLMIDLDHFKSINDSNGH
LFGDDALSVTATTLQQFFQPYEAIVARFGGDEFIVLLHLKEEQSISIIAQNLYDSLTSLV
LTVNDDVVQLEFSIGVSTNEHGYITQLEQLIHHADSALYASKRNGRNQITLYNQYNNVGN
SK
>A0A0Q8BM89|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. Root565|TrEMBL
MSSSSTGVPPAATAHTASGHDCYLSASNAQAWEAVYQSVDADTRGQGAAVVSDHATQLVD
AFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVRDQGDIDVLLATQKKVGEVHA
RVHIPIHLVMAGARILKNEIAQRLRASGLDGMAVSVATQYVCNLFDLAIEQMSRAFMRDI
NRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQALPRLAASEFGL
WLQHKGAVLFESAPALRQITEAVARLDDTVLPRMMQGGGHEHESLPDQVRELQELVARIK
HLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIALAQRQRSSFSVLLLDIDHFKAI
NDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAALAAAEKLNAE
IRRHRFMMAESGALQVTASIGVATFDGHPDYAYLIDRADKALYKAKQAGRDRSVEA
>H1W679|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MITMYFHHWQPKLNGFCRRIFKCLNQYRPIKAHLPSLKQLITILLASLLTIGLISGIRYW
GILQPLELESFDRIMRLNSDNIPDPRLLIVEITEADIQANQKWPFSDEILAQALAKLQEY
QPRVIGFDIYRDVPQPPGNLQIFEQFQADNIIAIQQIGRVEPPPYISINQVGFNDLVADL
DNTIRRNLMYVRYDGEEFYSFGVKVSQKYLESLKNHPIILDAQPGLLQIDETIFPAIRSN
SGGYQLPASEVGGRQILMDYHTKEIAKTITITELLQGEIDGNLVKDKVVLIGTTATSSRD
LHPTPFSAAKTTHHLMPGVMIHGYMISQILKVILEGESLFWFLPMWGEVLWLWLWSFFGG
ILVVKFHRPLSLGLLISISTIALWTICFIVFCQKGWIPLIPPALGLLFTGAIVLAYKVIY
GLSYDILTDLPTRILLNQKIQRLSNQSKYTQIALLFLDLDRFRLINEGFGHAIGDQLLIS
TTQRMKKCLYSQTILARVGGDEFAVMMPNIQNIDQAIAMANKLQKALAAPFYLNGQQVYT
TISIGIAYSNQNQDLIANDLLRDAHTAMYRAKALGNSRYQVYISTMKSHALQQLQLEADL
REAIKNQEFQLYYQPIMNLKTNQIAGFEALVRWISPQRGFVSPGEFIPVSEESGLIIPLG
EWILLEGCRQLAIWNQKYCQNPPFMLSINLSTRQFSQVNLIECVDQILTQTGVDRSCIKL
EITESAIMDDVDEAIALLERLKALGIKLSMDDFGTGYSSLSYLHRFPIDTLKVDQSFVRR
MDDSQQNTEIVKTIIMLGHNLNMDIVAEGIETEGNVQTLKNLNCEYGQGYFFSKPLPVTA
LEDLLNRTLYQS
>V6F395|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MMDDGRNQHGGDQDIGRLLNLVEIPECQSLIQPIIDHLPCGVTLFDQSLNMVACNGVFRR
LLDIPDELFAAGLPSLKKLATFDAGRGEYGLGNPEELAEQVVLRAKAMEPHQFERVRPDG
TILEIDERPLPNGGFVTLYMDITERRALVERSRDLEALNLELTDTVAALAASNAELHAAR
EELEHLAQRDGLTGAWTRRRIEETAQQEMLRKARYGHPVSLLFIDLDHFKRVNDTHGHAV
GDDVLKAFCKIARKCMRSTDLLGRWGGEEFVILMPNSGVMIASLLAERIRKATMAHEFPV
VGRVTTSLGVAECREEEIWESWLARSDAALYAAKAGGRNQVIKDAAHPGETGEAELLDLS
YMRLGWRKAYESGHSLIDSQHRDLFDLANNLLTSVLGDRPDDEVVPQVESLVADLTKHFH
DEEMIFRSVGYAAADEHAETHKSLLDHANNLVESFKQGELSVGELFNYLAYDFIAKHMLS
EDRKFFGQILEVHDTAG
>A0A0M7CV90|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MDPILAELSASLQAAKSVEQLTRPLLDMLGAVTGLESTYLTSIDPDEDQQHVRYARNVGA
LQIPEGLSVPWSDTLCKRALEEGRMSTSDVGACWPDSDAARQLGIQTYVSTPIRTDDGLL
LGTLCGASARRQDIAPQAEAIMRLFSSVIASFLEREQLVAELRTANTKLMAYALTDPLTG
LPNRRALYEELDRLRGRALREGGSVLVGVVDLDGFKGINDTYGHQLGDAFLQEVSRRLAM
ALRASDMVGRLGGDEFVLIGPGPALARGDAAPGHEAERGDAEEAARSLEDRAAAATVGRY
QLGETALPYEGASVGVVALDPRGLAAEEAVRLADARMYEIKRARKAARVIH
>A0A1W6VV59|diguanylate cyclase|EC 2.7.7.65|Geobacillus thermodenitrificans|TrEMBL
MKQEETKRYESFKREFFHWFLAFSGDEPFSVAAGELLVMLKEELALQQAVLYLFDPSCDA
FCPEAAAGRMPAAELIVAEEKQEIVVIDDGGPCIVVRLFFLLSEETRAMLELMYGKERHI
DREWLKVLRTDLSSLFRKLSALSQRTSEENRYEQLHRFAAKIHSTMQIDDVLEEIIRTLQ
NVYPAFTYHLLLSHDNHVCGNLPIKTLALDESEGQPAALRAFLTGQVQCEETAAPPRSVL
YAPIKGVQAVYGVIQIIAPYAAPFPKREINFISLLAGTAGRALENAKLYEQSRRLVADLQ
LINDTMRQLNARPRLCEAIEYMVSQIKESFGADEVGFFLFADGKRELLRGSTPFFYNDLS
ALYVEWVEARLLSGNDILFAGDVRTSDFGPFRSIMAAPMMQNKEMKGVCIVLAYETYRFT
FEMFKLLQSLVQHSTLAFMNAILREELEKLVVTDYLTKLYTRRYLDEAIQKSMEEDALGS
FLLIDIDNFKQINDTYGHQTGDDVLVQVAKMIRTNIRDGDIAARWGGEELAVYLPKVALL
DAIAIARRIVEKVREHTVPSVTVSCGLSSWRRHDHDDAEQLFKRADAALYMAKETGKNAI
FVHDGDHLYRG
>A0A5P9BFB2|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MKKDEFQKSTANLKKAVPLMMKNRVSTTPANYALWYTYVDNAIPQLNKDMDGVLEHYGIC
PPALGEQLYNDYVASKSETTINDLRANLELLVSEVSSSMNDTLTDTSAFSEMIDKSFEDL
SQVDNNSMSIDEVMSLVRQLVSESQNIRHSTQFLNSQLNAATTEISKLKSQLVEVQKDAL
FDSLTTLYNRRSFNKDLQMLCESDQALCLVLLDIDHFKTFNDTYGHLFGDTVLKGIARKL
KMTCRDGISAYRFGGEEFAMIIPNKSLRIARQIADTSRRSLEKLSIKDRRSGEQVGNITA
SFGVAELQPNETADSLIERADKLLYEAKSLGRNRVMPL
>A0A317PXA2|diguanylate cyclase|EC 2.7.7.65|Mangrovibacter plantisponsor|TrEMBL
MFAKLTNIKNPRKLVTLCFTLVFFGASLLVWREGVMLEQAYISDQRNTLDNIASSLDKQL
QHSVDILFFYQQAMEFSLDTPFITNSTHPSLKAFNRERHKPWWSISYDQRRTIPVFGVSE
EFVEQHSDLMRNNHALDRELSAALELSYLLPLSRYASTLQFRTWYISRAGMFVTSNGHKL
DKSVQTTFRRMLSRPFFAQQSPANNPDRTVCWSYYQDKTNPEYQVVTASVPLDYEGYWYG
VIGMDFTLDVLHGYLKGIAEQHSTDNGSVYLLDSKLTALTSSQGRHGEHLVMSPVDQARL
AQDMSSNTVGALRMQNRFITWAKLDSFDGVLIREHNLYQGLGGEFGHIILLLVFVWVMFT
VLLIGTWYFIRRLVTSMSVMQNTLSWRANYDTMTRLFNRGAFIDQAQQLSARCRPNSQPF
SVIQLDLDHFKSINDTWGHQAGDKVLKHAAAVISNTVRGQDIAGRVGGEEFCIVMPGASI
TDAAQVAERIREKLASKPVVYSAEVVIAISASFGVSSSTEKGDYDFEHLQSVADNRLYAA
KEGGRNRVCAED
>A0A1W6VS76|diguanylate cyclase|EC 2.7.7.65|Geobacillus thermodenitrificans|TrEMBL
MVFERLKNKEKLYTVVVSLLGMCIFATEVDIHSQSLKDWVLVYILTGSVVLLNLFPIILP
PKANSFSMDSAVYLATLFLYGLNFTLQVLFIFSLIELYRNQRMSAWRHLFNFSMYCLMIS
GAYYSFLFFDGNIGKINVHHLLPYLISLLVYFSINVLLIFLFFYFIGQIFKGALELGVLK
EACVGYSVTLLLSMVLAILLSEEKYFGLSLFIILVTILSIVFRKFLELYQLVSNRANRDH
LTGLYNHGFFKETLKEQFSDCKLLKQPLTLAFLDLDDFKKYNDRNGHLQGDRLLAFFGKL
LQKAVEGTNFTVARYGGEEFAILMPNTTKEDAYAFLNRLRKEVNDTYFDGVEHIPYRCLS
FSCGIAEMEKDMHESDELIHRADQALYYAKAQGKNNVQLYDKHNMCLDEIKFKQDLEALE
QQVKFFLSKDVYTYRHSKRVFKYALEFGSRLDELTVHERQTLALGAIIHDIGKIEVPRDI
LNKSGKLEKHEWEIIQKHVAWGREIVAAEKRFDELLPLVELHHERYDGKGYPYGLKGEEI
PKLARILCIIDSFDAMTTERPYQPTKTFEEALEEIERCAGTQFDPVYAAKFVAFVRERYL
PLAEMQQLN
>A0A378TIZ1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MFRPNSLAGAGGRVGGHQVRLLRIYLGATTFLYAYGVVFTIFPVRTDIAYANPAGGIVAI
VLGAAALAQLAVWPRRLAFATVASILATPVVMAFHVTLTAEYMCLIAPMFLAMYLRAFHR
PGRAWLMIGCLTVACVVAVVMAPAPHVGVITVLIIIVAIIGAAESFGLLMRALFADSCSD
PMTGLLNRAGWEMATAELVTRARATRAPVTVVALDIDGLKRLNDTYGHDAGDRRILDYAQ
TWRRALPRGAALARLGGDEFAVCLIDDKPEIVADFLGVLRSQTPDASVGTATSAELGIAD
LYARADAELYRSRGRPLTRRTDHDVVPNSGFPESR
>A0A6H1FRX5|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. FDAARGOS_727|TrEMBL
MIIKNRQTDTALHLLILLVGLAILSFIFTLYSMELTLKGTDLVPIWFTTSVMMAAFFRNP
LHRWPVIALACAAGSLAASLLLYPPSWLNLILTSINVLEALLGAILLRRFLPRKNPLQTL
NNWSKLAICSAAIPPLVGGLLVVLLPTPVDSTTLKTFLIWVLSESIGALALMPAGLLFKP
YYLLRHRKTSLLFETLATFAITLGLSYLSLIYLPWPFTFIIVILMWSAIRLPRLEAFIIF
LATLMMVSAIIAIGKMPLSTPHPKVLEYAPWLPFLLILLPANVITMVMYSSRIERKHITE
SETRFRNAMEYSAIGMALVSTEGKWIQVNKSLCKFLGYSGEELGNLTFQEITWPEDLNLD
LQHLSKLAAGQINSYSMEKRYYTSAGNVVWAMLTVSVVRNTDGSPLYYIAQIEDINDLKH
TEWINKRLMERITLANEAGGIGIWEWDLTSDVISWDKRMFELYDVPQHVKPTYQLWLERL
VKEDLAHSEQVIRDSLKNRLPFKLEFRINVKGGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNVSFMNPIAEKLSGWAQEDAVGQH
ILAILRITFGDNGPVMENIHSGDFSRTAIEQDVVLHCRSGGSYDIHYTITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENHLKQLLQGALDHRQRHALVFI
DLDRFKAVNDSAGHAAGDALLRELAAMMLSMLRTGDFLARLGGDEFGLLLPDCSTENARY
ISERIIRSINDYHFMWDGRLHRIGASAGITHIDGDNAIASEVLSQADIACYASKNSGRGQ
VTVYEPNRHYMEQGRDTMPLDEQWRVIDDNPLLMVALAVAPPRIPESTCFYLLSLRFWGS
EGDVIDEPAFRAGLADPALHLALDRRVFNEFFVKFAAQVTMKGFGIALPLSGAGLASNSF
IDELLDRLRETRTPARLLHLTINSADLLENPEPVHANLKKLRAAGCRTILSHVGRDLELF
NTLSHQLFDYVMIDPELILNVHCNLMDEMMITIVHGHAQRLALQTIAGPADMPLVMDTLS
GIGVDLIYGETIVQPQPLELLLSNSYFGIN
>U1XUX1|diguanylate cyclase|EC 2.7.7.65|Alcaligenes sp. EGD-AK7|TrEMBL
MSQPNIEEAAQDWHGLLQKVPLAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHD
QVHKRLHRSLRSWLVQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFLFESSTISSEQAWECYRYIQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNLIDTELMPAFEQGDAKGQVLRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTHGHDAGDRILRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMSITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYV
>A0A2K8RII1|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. M56|TrEMBL
MVERLGTDMAERSHSWGDERLSLLSAVGTALTDREVMRHALDQAVSELGGLAGLVHWSCG
PAGSRTLRLVLASGLPLPALTGWEEIREDEAPNAPARAVRDARFVWLPAASDASPGPGET
GRTSSGTLPPGTTVAAVPLSGPGGPVGALSVLTGPREPTPEQTGFLEAVGRWAERRLSRS
TAIGGCDEHPWWQQRPGGSVVQQSLEAVKAGSWEWGIRGGEMRWDRAGLALLGIPRGYER
RIESWINLIHPEDMPRVMAATEKSLHERSCYEAEYRVRRPDGTTGWVQSRAHLELDEGGE
PVRMIGKIWDTTESRMARESVGQALRYMSDAFFAVNRDWRITFLNVEAERLIGAAGEVLG
RPLWEGPAGMVPELEDRCRRAAADGRPTGFDIRWPTDDRWYHIRLVSVPDGLTAYLTDVT
ERRTQAARRAAAERIGAEQAARISELSNALADAVTTKDVVRVVAAHVLPPFGASGLLILW
LEGGRLNVVGSVGYSRAFISMVDGVPAFGGYRLLNEVLGSRRPCFISSTEEYQRLFPDLA
GNPAIARKNAWAVLPLIASGNAIGTCTVSFDEPHDLSADERTLLTALSGMVAQALARARL
YDTEHARAQALQRGLLPRALPSLAALTPAVRYLPASSGTDIGGDWYDVIPLSAERVALVI
GDVMGHGLAEAATMGRLRTAVHTLANLELPPEEVLAHLNEVVCDLGDDSFATCLYAQYDP
VTGLCSLARAGHPPPLIVDPEGGVECLDPTPDPPLGAAEPPFSTVDLRLPDGSLLVLYTD
GLVESAARDIDTGIAECTQVLTSDYGRLLTCPPRRSRIGVRGTGGRHAVDHDRLDRLCDL
LVGAMLPAQRLTADDTALLIARLHGLASGNIAGWPLPEGPVAAGLARTRVREQLRAWGLD
ELVATTELLASQLVANVVRHARGPTRLRLIRGRSLICEVSDAGAAAPRIRRATELDEGGR
GLQLVSALSQRWGTRYTDEGKCVWTEQPIAWAGTPR
>A0A4R7YNE6|diguanylate cyclase|EC 2.7.7.65|Halomonas alkaliantarctica|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAIETLVEHHGQNFADHFYRVMLEDPHASLFLSNA
QVEQRLHPSMQRWLKAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLSGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQNIG
DERERQRSALLNWENALMFAVAAQQDIATLPRLSNSDFGLWYLHKACHAFEGAPEIATIS
RHIKQVDCEWLEVLLHEDPSQRLKALGEIRDAARTVLMLLDDVLQRASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTVSVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A1U9Z209|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
METVVARTILSLTGPGIVLTFSLAFAVFWLIERRLLYLPVLALSCLLFTLGSLSQILGWP
PGVGANALVSGALYTLAVLLTVQGILLRAEKPFNWWLCLAVFAVIMALLWYFFYVDRNLT
ARIYVQHFGYGLIMVSATVPLAKRPAPRPVDRVLFWVLLLFALHFFPRTLLTVGSWIAPG
VAAFANSVFWQAMLFSIGLLAAVLALTLLFAAFSDVLHDLRRERDYDALTGVLNRRGFGD
RIDTELPVIDNPVSLVLCDIDHFKSINDLYGHDQGDVVLREVGKVLRQNARKHDIIGRLG
GEEFAILMPDTDVEAALQFAERLRAAVEAHHYGLPDGATDVTASFGVATREPSESWNALF
KNADTRLYVAKRGGRNRVVNHDNTLP
>A0A4R8ER10|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. BIGb0552|TrEMBL
MLGNALQRVIGRFKNPQKVVNLCFIFVFLFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHSIDNLLFYRNAMLYALQSPISTDRTRKSLADFDTLRTQPFWQLRLDLSRSLPM
SGVSDEFVNKSPLLDRDEHTLHSELSSALELSYIMRLSDSSGKMPQRMFYASRSGFFLTN
TPPANDPNIVSLYYRLIARPYFSSQSLQNNPQRSLKWTHTFNGNYTSGQIVTASVPLDFN
GRWYGVLALDYPIESLHNFLREAKYDDHEGTVLLYDNELNPIATSARSLPQHELFTAPQL
ARIANVVTAAKQGEEGELRMDSRFITWAKLNNFDGLLVKVHTLEEGVQGEFGRISIVLSI
LWMLFTLMLFASWMVIRRLVNNMFSLQQTLTWRANYDTLTRLYNRGAFFEIARKLSQECE
QQGLPFSVIQMDLDLFKSINDRFGHSCGDKVLIHAAAMLSDAFRTGDIAGRVGGEEFCIV
LPETTLEEATKVAERIRVRINTKELLIKQGNTVRISASFGVSSSFEFSDYDFERLQTYAD
HRLYKAKQGGRNQVCNHD
>A0A4U8Q910|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MRNNGEEDVIEIDNLPCGFCKIRNDDDLTIVSANALFYKSFGYVPQEAESAGFTTISNII
YPADWPKAKEKVDRCKKEKLDYIDIEVKAIHRSGSVLWSLIKCTADPHEADCFNCVVLDI
SKRMEAIEVLKMGEKEKMLLLGHAKRFAFRFYPMTRAAVLSEDTALELGLPVKVENLPES
IADTYPAKESRTEFINFYDRMLEGQPKGTAILHFRNKTGDYTWYECSFSMVYNRDGMPLH
AVVSFEDISEQREKEIAYEKWSQFNQSQQEKAVAYYECDITKNILESVRTDINNILPEDA
VVSYDKTLEYVVDNLIVPEDRQGYVELFCRSEMIRQFHNGKREMKMECQRYAKDGNVYWV
MASLQMLPDPYSDHIKAFILITDIDKEKRKALELHERSRRDPLTGVLNRRAIIDQVTDVL
DKSQPNSNHIFIMVDIDHFKELNDNKGHQFGDWVLSVITSKLKESLRADDILGRLGGDEF
IAFLKDVPDEHVIQERLDTLLQKLAFSTGSAYNITGSLGIAVYPKDGKDFDGLYKKADLA
LYEAKRRGRNQYVFYKPGMIQ
>A0A3S5DN77|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFLPVAAVLVTQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGM
WIALMGVNMLPAAALFMMMSMNLMGAGGRRLFTVGNGPFAGVMSGDVAACRATRRDAKLV
AGSHALFARHYVVSASVRLGKLPNGH
>A0A509E0N2|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MHGFHPHNQPINVIIGGNRKHSGLLHLKLTSLIRTLLLTLMIGCAVTVHALAPSQSSRFK
SYLGEQGLNIGSVEAIIQDYQGFIWMGGTDGLARFNGYEFKTFRYQDMNSQSLSNNTVWA
IFEDSKHNLWVGTEAGLNLFDRENQSFTRFVQSEDDRNSLPSNIIKSITEDSHGSLWIGT
YWGMARFDVEQKRFTRFYHDPNNTNSLTSNLVRHIEIDHEGYVWISTEGGGLDQFDTEQN
IFTHYVNQPGNPGSLPHNIVNEVYEDRQHQLWVGTDNGVSLLNRRTASFTHYLKAEEASP
SSRNHVSAIHQDSYGNLWVGTDNGLFILESGQQDFSSIERDPLNPYSLTSNAIRDFCEDK
AGDIWLGTFPEGVNFLDGNNMAFRTFSHNPIDKHSIRHSSILSLKQDNQNNLLIGTDGGG
LNLVRYPDNKLITALEHDAEDSNTISSDSVLSIAVEKNDVIWAGTWGAGLNRIDLKNASV
DRYFLDYQNDKTISNNNVWSLFLDRQQRLWAGTIGGGLNLYDETINGFHRFPHNPASAKS
LSASLVWDIYQDKQDRLWFATGSGLNLLDENTNTFLHFAYPETHPNHLAINNMLTLHEDK
QGYLWIGTRGAGLLRFNPEDGEFINYNSSNSDLINNMIVSIEEDAQANLWLGTNHGLVKF
SPDNQEVFTFDQSNGIQGNQFNLDASLTLHNGELVFGGTKGYTLFAPADVKHNTLPPRIV
FTDFQIFNKPVIIGAEDSPLQRAINYTSDITLNHKQSVFSFQYAALNYRHPNRNEYAYKL
EGFDKDWNYVDDQRIATYTNLDSGTYTFTVIASNNDGVWNKQGKSITLHILPPPWFSWWA
YTLYFMACLLLVALFFNAQRRKIEYEIELNRQLEKQVAERTKELEEKNSELKTAYTKLED
ISQSDPLTGLYNRRYLYRFLPHDSSKVIRAYANWDNTRPQAKDSDLVFFLVDADHFKSVN
DEFGHINGDRVLIQFSEILKQVCRESDCIVRWGGEEFLIVSRFTNREQAPAIAERIRRSV
EHHIFQMDNGQTIQRTCSIGFACFPFNRSAPDSLTPEQTIDIADRCLYMVKKNQRNGWMG
FYLADEQQDNIIALLDNPEKTIEKGWLGMQTSISKPLTWD
>A0A6I5ZR19|diguanylate cyclase|EC 2.7.7.65|Moorella glycerini|TrEMBL
METHLQLFGHGKGSIGVAFILDLTERKKMEEKLRQQGEFLRSLLATLPVGIFIIDPASHR
IEKVNLEAAAMIGAAPEEIEGRSCREFFIQSAESCPITASNEEVDRSERLLRRKDGLEIL
VLKTVKRVRTDSGEKLVETFIDISERKYLEEELYRLSITDPLTGAYNRRYFLEMLAREIE
RTRRTGLPFALIMFDLDHFKSINDRFGHAAGDRVLKSLVAAFKERLRKTDCLARWGGEEF
VILLPDTTAEGAAGLAEELRRRLSQMEIPGVGQVTASFGVTGYYTGDTVDTITQRVDSML
YRAKENGRNCVCAYQ
>A0A379WZQ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPLL
FAWVSYQTPLN
>A0A379VWK8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MDKKELISPLSPYSLGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANIVAF
TLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLAERE
TLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMGDQA
LIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHMFNE
SVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A1S7RX83|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tomkonis CFBP 6623|TrEMBL
MEETAYRGIDRQTEPGHTLDLTTQPENGRFSRRRSLASKITLIFLGGVIFAYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADDGGQVNGILTDKPIGDDESILV
TGFNPSDVLALIGAQTKNAVWLFRYDETDAGFRQIAAAFDNATDDAEKPLATDPIFAKDG
VAARFATGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDIVTPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAEQLEHMAHHDALTGLPNRVLLRKTLENRLDHLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQAGSDDYRA
DAALLAKRVVHAVSRSFNLEGSDISVDTSIGIACAPDHGTSATQLLQQADLGLYRAKSMG
CGLFVFYEPGMDMAAQHKHALEIDMKSALENHEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLITPDRFIAIAEENNFIKPLGEWVLAQACMDAMAWPKDIRLAVNLSAVQLGNDDIV
PVVDRALETSGFPAERLELEVTETAMLERDSSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPTNPMCSAIVNTIIDMADQIGLKVTAEGVENSEQVAALKLC
GCDEAQGYYFAEPAPLAHILKNRAIITPAGKDGFGGGDGQSLRDTGRPIQETYNPPQKAI
>A0A1C5TDM0|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MKKLSRHELMQYGTAIISFLIVMTFTLLIFFWFVQQSVDKSVQNVLQKNTLQQKDHLELV
LEKEYEFLESPAAYFGTTSDLFSNDNLQLLAELASSSSYHRLMLFSTDGIGHSSDGKKTD
ASSRDYFQKTLEGRRVISSPLSSSVDNETLVVLTVPVYDKDQNIIGVFGGSIDVTELTTM
LFEDLYSGSGYSFITDPDGNIISIESTHNEIRKNFFTSSSDWVFQTSEDGATLQEDFKQG
HANCRKIISDLSYARYISYQPLKYNGWMLCYIIPAVDARQPFAFINNFEIILFAFFICIV
LLLIFALWKINQKNQTSLLRQAHTDALTGLLNKVYAEHTISEWLREKDFEDLQALMMIDM
DYFKQINDTYGHATGDQVLKIFAGFLKEQFRATDIIGRVGGDEFMILMKNVRLDYSIHLH
LQKLYTNLQNIDIPELNDQKLSCSIGCAVAPTDAESFSQLYRLADHALYTAKHNGRGRFV
IYHDIKNQQETVLS
>A0A0U5ID85|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MRKGKQPPRISRHDGRPNRTRFTATQTMTSDRNDKERPPQAVFGAIGHEADAAAIERLRE
RAAQALDSGRFDLADELLAGVDGQEIQLAKLVENLRIYQAELEIQNEELQLSQRHAQDAF
ARFSAFFNNLPLAGLVIDRQGLIKETNQRARTLFGLRNRPGHQHFFARLIADTDRGEVIH
AWSSLAGDQPRELAELHFQTLEGDRFIGDLHLATLPGILDDAPTYICAVLDRTESARQRR
ALAEATERLRRSESFLNATGEIAKVGGWEMDVPTGRVRWTDVTYRIHDLPPSEDPPLALA
LGFFHPDDRQLLEHRIERAIARAEAYDLQLRMTTAAGREIWVQTTCQPICEDDRVTKLQG
TIQDISHLKRSEEQLEFLAHHDPLTGLANRSLFRARLELCLQRAARNGTQVALLFLDLDR
FKYVNDSLGHSVGDQLLERVAAALAAQVRSSDTIARLGGDEFVVIMDDVGKPRFAARFAR
RLLGVLDQPFATETRELYITASIGISIYPEDGADMDTLLRHADIAMYRAKENGRNGFNFY
EPAMSAGAAERLRMEHELRGALARSEMMLHYQPQVALSDCSLRGVEALCRWQHPRLGLVA
PDQFIPVAEDSGLIGELTAWVLEQACRQLILWDQVGFRIPRLAVNLPMREIERTDLVNRV
RRTLERTGLAPDRLELEVTESMIMRRPDVAITTLDALRALGVILALDDFGTGHSSLTYLK
RLPLNRLKMDKSFVERLGEDRDDEAIARAVIALGRSVGLGVIAEGIETRTQHDFLRRELC
EEGQGYLYGRPLAAGAFMESWSMIEGSARLSAARSASAPEPEPEPEPKS
>A0A8B3UT77|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MLAICRFVKNRFVAFALGCIVIIAVLQGFFIKLVAWVPSFSPLFFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLVPIALAFAGSALLMVGTLASFPAWLDLYQFNEANYNDAMIFYMF
RHFLMAVLMIVAALLYTLRNSALSRSAHVGIVVGASLFTGCMLGLALFYSSHSTLLTLDL
VDNETRQFMVLWSQAINIILIVLWVVTLITLLAITRVRNLFWVGGNFLCVCYIVTLLMLL
LGGHAEDISWYRARLFETVATLMIIFILLSDVFNLYRDSHVKYQQSYQNSIRDPLTRLYN
RSYFYDSLNHALNTATVTHPVSVVVSDLDRFKRINDCYGHLQGDRVLQFVSNLLTDSVRP
QDIAARIGGEEFVLMLTNTPSDVAHQVAERIRLKLSGFDKASSGGQLPEPITISMGVFTA
TSPETSAETCVESADKAMYEAKETGRNRVVVFRT
>A0A1V5QNZ2|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MLLFDRLHRTIAHARRNDELFVLLIIDLDRFKEVNERWGQDAGDRVLRIVAERFAAALRS
TDSLARMGGDVFAAIAEGLMFGDDVEPVVQKLRGALASPISLAGEALHLGATIGMALFPA
SGEDAEALYRAAETALRQAKEKHRGGLVIFEPGIGAGG
>A0A827N2G1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKHGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7T2JJP0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQADDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8G7VV58|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTLASGIAITLTRHLHNG
LVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQ
LLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDR
VLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNG
HQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8E2GTV8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIVKRRGRNRVELWKASL
>A0A826SJE1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAVSILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLLWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVIYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
RQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKVVNDSAGHAAGDALLRELASLMLSMLRSSDMLARLGGDEFGLLLPDCNVESARFI
ATRIISVVNDYHFIWEGRVHRVGASAGITLIDNNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGITSPRLPEASNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQVAKAVASKGLNIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A6L6ZSP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHA
>A0A8H9SJP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRTVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGDPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8H1IBL2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A828FY88|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQAAPIIRTKAAEIAVTHAHYLSNEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTGAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFNQTILHAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASETDTLRTAERIRSRVEKTKLKAANGEDIVLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9JFW8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQTAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H9XUX3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYS
>A0A8I0CGD2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
PTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDY
VFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHP
DYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6N7KF62|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVIEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376MRZ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWW
LSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNC
RRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAV
IMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLA
LYKAKKAGRNRTEVAA
>A0A828HEE9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERTAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376WXE4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATEHWQRWASKGNFQLQKYVISSKIFWHPGITPVRIRRYFQ
>A0A6D0DJB1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A1V5QP04|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MAHDDRVSKQVRESLNSNAPRVVLSVPLIIYNRPTGALNLFWDQMSVLSAAHQEVLMSMG
HVLAAAMEHTTREYEALHDALTGLLNRREFEHCLTNLIAISDRYANYFSIIWIDIDDFKR
CNDEHGHLSGDLLLQNLARVLKQSLRISDVVFRCGGEEFAVLLPETDQAAAAELAERLRA
HFSNYEHIDVNGHRYRSSISLGVAQYVIAEGRESFLRRADAALYAAKDGGRNRVEIAER
>A0A2G4AG36|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSLLQWQAWHDTLTRLYNSGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3R1BF46|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASEPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7H9LPI2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLSGWWWLVLVGWAFVWPHLAWQLASRAVDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMAVSCLVTLELTGITVSLKSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLKALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A376K413|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
NVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMA
>A0A822UD02|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A4P6I7L6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVLDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376KQT1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMTYSLEAAVVFADGPAATETLAA
LGQQGQFSTAEVRDKQQNILASWHYHP
>A0A377A1N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGHSITMNYLTFG
>A0A1M1UUN8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLMRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRWMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKMCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A0K4LEN8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVRMHFRLYQNVKRENISDAMTGLYNRKILTPELEQRLQRLVQAGSAVMFIAIDMDKLKQ
INDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPHTAAQLPERIEK
RLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A0J2EML5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDNSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2X5EMD2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGGFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIIGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A377ZCU5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVIRHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAIAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A376W4I0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLICIILVASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVHAFSATFLRRIHI
LLIGDNMRIGIIFPVVIFITAVVFLAWFFIGGYAAPGA
>A0A2I6IE25|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLANNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A376VMC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLN
>A0A377D1J2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVFAKADRNRTGDYFRRYRSAGNAGFKSQSL
GKLSAQKTRFLCALFSD
>A0A793GII4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVNKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2J7Y697|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MKGNRTLEAPKLLGITWPFIAVVVLQVALGSLSLYTLSAVRAYVAGESLWSKAQKDAIYY
LSLYGETQDDSTYQRYRQAITVPQGDHRLREVLDHPSPDLDAARQAVLQGGNHPDDVERI
IWFYRNFRHVSYMQTAIDYWDIGDDYLAKLDVLAGEMRQRFADGPVDADTVSDWKARIVA
INEGVTPAAKAFSDALGEGSRMLLRVLLITNLLTAMFLIAIAWRRSSKLLAQRQAFASAL
QEEKERAQITLQAIGDAVITTDVEGSIGYMNPAAEQLTHWQSGQAQGLPLSALFSLVDEH
AEEDGRSLVEQVLSGSLKGGSEHARLIQRLDGSTVSINLVGSPIVNDGQVSGIVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQALNDLARQAGRHSLMFLDLDQFKLVN
DTCGHAAGDELLRHICAVLQSGLREGDTLARLGGDEFGVLLENCPPDQAERIGEQLRQMV
QSLHFVWKGRPFVTTVSIGLVHMAQAPGTLEASLRAADMACYMAKEKGRNRVQVYHADDS
ELSMRFGEMAWIQRLHVALEENRFCLYAQEIAPLKTFEGPGHIEILLRLHDESGRTILPS
SFIPAAERYGLMTALDRWVVRNVFMVIRQCLEEGREGPLSTCAINLSGSSIGDDKFLEYL
QRLFVEYAIPPRMICFEITETSAIANLGSAIRFINELKGLGCRFSLDDFCAGMSSFAYLK
HLPVDYLKIDGSFVKDMLDDPVNRAMVEVINHIGHVMGKRTIAEFVETPLIEQALQEIGV
DYAQGYLIERPQVFTCDSLQRQRIAARPLLQRAPGTFR
>A0A1Y5KQA0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MDNRIGKGLSFVKRIYLPRVIGLGIGLFTVMAAIAPLSPPSWAWLLVLFNGLLWPHVAYQ
WAARSTTPYQAEQRNLLLDSLMGGFWTAAMHFNPLPSVTVLSMMTMNNVAAGGKRMVFRG
ALAQLAGMLTAILLLGPGLQLIATPLQVYACLPMLALYPLALGWVCYQLAIKLGDHKRRL
SALSLTDSLTGLFNHGAWKDLLQLKFQACKQRQEHAVIALIDIDHFKTINDTFGHVVGDC
VLRQLSAELRRSLREGDQAGRYGGDEFCVILPEISEAQACQVMERLRERVSSYRNPQLPH
LRISLSIGLSPFEANLESPEHWLEQADKALYIAKHAGRDQVNFARSEAAALRLAYSD
>A0A120DAB1|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MKEMRVLLIDDDEEDVLLVRDYIREGFKNVSLKIVDVQTVPDAIDKLLTDKFDIIIVDYM
LGETDGLEVIERARLEGITTPIIFLTGQGDEEIVLLAMKKGAKDYLNKARITAELLCHSI
MNAIKLGELQSMRLDAERALRESELRYRTLVAFLPAIVCEMSNEGIIDFLNDSATRILGI
NPKELIGRGWRDCFLPQAQKSSGDEDFSRNLEKFYNILSLCSINNLELKTSIEGKTDKYI
NWNSTCLYKDDGTPNSIICVGTDVTEIAILREKLHKLSIVDELTGLYNRRGFYTLAEQQF
KMAGRYSKQMLIVFLDLDGLKHINDTRGHKDGDIIIKAAADVLKDTFRESDIIGRMGGDE
FIVLVTEMADEAEDTIKTRLAENIEAYNLSLRENNMTLSLSTGITIYDPVKPATLDELII
AADALMYKDKEHKKAGRRTIA
>A0A5E4XY18|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MTERLPVERSKAYRLLNHGPTVPVGSAHDSAHRSADEVTEAIAQTAHALWRTHGTTGSTS
SHLPSDDRRGRIDAVTDIIDRESPLASTHRDMTASEADLHASHAPASTPRHGPIPDTPVD
EAERLAALRRYEILDTPPEPAFDRVVRLASYLFGAPMSLVSLIDESRQWFKARQGIDTPQ
TPRSMAFCAHAILGDDVLVVTDARADRRFADNPLVTGEPNIRFYAGAPLRTPEGHRLGTL
CVMDRRPRMLDDEKRALLADLSALVVDALELRRVNRVLGEMAMRDALTGALNRRAFLMQA
ERLFSTARAQQRRLSVLMLDLDHFKRINDAWGHAIGDRVIVELTQVVRATLRKGTPIGRL
GGEEFAVLLPEADAQRAMQAAERLLVAIGNASVPGPSSGASGSIRFSASIGIGSLTPDDA
EFGTLLQRADRALYAAKQSGRNRLAVM
>A0A087BS26|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium longum subsp. suis|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKVQPDLIVLDVML
PDIDGFTVTRRIRQEGITAPVLFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVADLEINEDSHDVTRAGQPVDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVDDGEGGKRKVTPLIETKRGIGYMIRE
PKN
>A0A1S7LEN6|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MLSKDTTGNRSERKQAARDTARLINTLMENSHEGIMILDGLGNVRRVNQAFINMAGVGSA
QLLGRNIVRFVQQDLRAGLLEEVREELWQSGFWQGKLSHEQFSISEDLSIEAKVSAILPE
RGRVRYYLVQITLRGDDEDEEEGGSRDELTGLPSRLLFEDRLQQAISQASRHRNCLGAMF
LGLDAERIKLIRDSLGHDQADELIQEVAVRLGECLRTTDSVARMGDTSFALLLSDLNEHK
DAVRNASVVARKVYESLVNPVTVSGQPVEINAAMGITLYPADGKNPRELLLNAETALNHA
RQRGWNNYQFFSSEMTEAARERFELETSLRMAIERDEMLLYYQPQVDLESGDIIGAEALV
RWRHSEKGLISPGQFIPVAEETGLIVPIGEWVLRTAVKQIATWKELGLKPVRMGVNLSAL
QFKRQDLAALVAELLEQHDLDPSLLDLEITESAIMDDTERAIDMLNRISALGVKLSIDDF
GTGYSSLSQLRQFPFQTLKIDRSFVTDLSKSGDKAIVSAIIAMAHSLEQTVIVEGIEELD
QLSVMKELKCNEMQGFLFSAPLPAEEFTQLLKDGRKLDE
>A0A162KTR1|diguanylate cyclase|EC 2.7.7.65|Clostridium ljungdahlii|TrEMBL
MMKKRASENYLIKILLIFIITVAFISALWLDIFYEIGNHKKNIIDAFSREQYSTTNQLSD
RLQESLNDYVQNKGLTLHLAEEKAISEIIKKEINSQNKYVFFYNSKHILFERNYLTTAEY
KGKGLKDSFNLWEYNGGSNLDEVKNLMNSGISGKGEIVKDSKKGKEIVSWCFFKVLNDKY
VIGMSTSEDYLFRETLFNQHVVRLYILGGIATMAIIILSAAFSLYLYFMFKKVKSLTNQL
KNKNIQVQNFVSAISQVEKAARKATICDLLTGVYNRKFFYTILPKMNEKLFFPITVIRVS
IEGIKNVNNVLGRGKGDEVLVELAEILLESCNESDIVSRISDNKFVLIMINTDREAAFRK
VDEIGEKIRSSFIVPICSIFFGVAVKTSETQNLFRILKYTEKNIRQL
>A0A2N7QRX0|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MSLRRCKAWPRLALASLAFCVLPGVMHAAGTVTDPGEFLEQTERVRTIDHPRFVAMLAQI
HEEASQLTPVQKWYLRYLDGWQTAFEGNATKANLMLQDVIDHSGDATLKAKAMALLMHNL
GLSNHYEEAFTLANQLASDLPTVKDRLARFIVLSNLSQLMVYAGQTDLAIKYARMMEDAV
PPGESLCNPLSMEVSALNKTDRLTSSSPKLQEAIDACSAAGQPVFVNTMMLIKSDLYLTE
DRPEKALALLNRLAPSVAANRYYSHMRAVQVQLAQAYEKLGDEANARKAALAALTMSGQD
EVSEWVRTAYDVLYKVEKRRGNPAASLAYYENFVAQDKGYIDDISARSLAYATVQQHLLA
QRLEAEGLSKQNNILRLQQALDTKAVETSRLYIALLLLLVISIAAWLLRIKRSQLRFKML
SFRDSLTGIFNHQHFVSEAERVLRTTERKSGAACLISIDLDHFKLINDTHGHAVGDIVLK
HTVTLCQRQLRPTDLFGRLGGEEFGILLPDCTREQGVAIADRIRTAIEATPVEGDGRLVT
FSASIGLASTDSSGYELQLLRREADAALYRAKRTGRNRVIADNQLPGMIRA
>A0A0K2WEQ5|diguanylate cyclase|EC 2.7.7.65|Aneurinibacillus migulanus|TrEMBL
MTWRQEIYQILHSLKGTAGTLGYHPLSHIAETGLLMFTDSTNCTLPNYMVSPLYTLIHEA
MDQLRSTERAFVSEDIIQELQVFNKEDEKPKRILIIDDDEVLLASIYQILSLAGFDVEVL
SDARSGLEEMLNKQPDCIILDVMMPELNGFSVMQRIRSDAQRQFTPVLFLTAKSNIEDKY
KGFQLGADEYLTKPFQFEELMLRIKTLISRVEKYRSLSMKDSLTGLYNRRYLIERLQELF
VAHARKPQDIALAIMDLDYFKRVNDTYGHPCGDAVLKSFASFLQAKLRDSDIITRYGGEE
FIVVMPGTTAEQARDTLNRVREEFGRHEIQCEDARIFQTFSGGIAQLGNEGEDIPKLIQH
ADQALYLAKFNGRNRLCLASEVEAAGEEARHKKVLIADDDIVVHSILQHQLEDTGWELYF
AQDGYEVLELVDNMTPDMFILDGFMLQMNGLETCQAIRKQPRFAKTPIIMLTGRSGEEEV
AQALDSGVDDYIVKPFSPIELKARMNRLFVRTK
>A0A7I6QN09|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP3-S18-ESBL-05|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNELLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYQAKQNGRNQVCTED
>A0A8F7M1U6|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MTESDASCQRARWLLPLWVVISTLTTLPLRADEHLIVQLPWQHQFQFAGYYAALAKGFYR
DAGLRVTLREAGPRTDVINEVTTGRAQFGIRGSDLLLARAAGRPVVVLAAMLQHSPLVLI
TLDRPDIRTPADLAGKRLMLEPGANELLTYLHHHTRDKTWETLPYAQGVQALITGQADVI
SAYSSTEPFALARGGIPHRVFTPREIGFDFYGENLFTSEHEIVTNQERVDAFLQASLRGW
RYAMDHPEEMIDLILTQYPGRADSAQLAFEARETRALMQPDIIEPGYMQPERWEQIARTY
RDAGMLKAVPNLAPFIYNTAQARLLQQRQLFDRSVTVAILVTLSLLVLLGIFLYLYLRLR
QEALDRQRLTQELVQREQHYRFVAENSGDVIWTMDTASLRLRYISPAISSLSGYEPAELL
NLSLRRLLPDDSWGRLRDEIAASLAAWQRGEHDQTRCVIHSQLRHKDGHLVAIETVTTLH
GNTRAWPDAILGVTRDVTERSAREEMMRRLAFYDPLTQLPNRRLLQQRLKETMAQAPERP
LALIFIDLDHFKPINDTFGHETGDQLLKQVAERMRHCVREEDLVARLGGDEFVILLPDTD
AAALAVADKLHQSLHHPFSIEQQALCISGSIGVALYPEHGTDPKTLMHHADQAMYQAKHH
GRGRVCLFAAGLAPDTLQWQPAHECGHPRIDAEHRQLFRLTNRLLERLNEPDGRPDRLLE
EMERVFEMARQHFAAEEQVLAEHDFAELEAHRQDHRRLLSMADQLMAAARAGTLGHDELL
NFIIHELVVGHMSQADRRYFALFEAGDVRQQALG
>A0A377HIY5|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MLGMSQSLALSETDKETIIVTNSHSWKPFAFSENGIATGLLVDYWRLFSEINNTPVEFAL
SDWNDSIEAMKTGGRKVHGGLLHSESLVDTLDYVLPLFEISTTLYVRNRDEELRTQGFLP
GMVIGVVKGSYEEEYVQTRYPLVATLGFDNNAALIQAAHNGKVNRMLLNTQVATYYLHQQ
ENPNRFVPIERIYQKMLYTAIPKGNELLFKEVESGIKNIPPQEIARIKQKWLNTSKTTQI
PHWFWPITASLVFLVAVSYIILLKKAVTRKTRALKALNVKLEDYAYTDSLTGLMNRRGLD
RMYSSKRVSNMRKRGKLGVLMLDVDHFKQINDKYGHLKGDEVLNNLGGVLTDYVREAVAV
ARLGGEEFCLLLPAEDVRDLEVNADYVCSCLVPQASQTQLDLHVTASIGALLVDRESPET
SLEALLHHADRLMYQAKEAGRNRVVVSQLSHQRFHRYAGNITA
>A0A378JLK3|diguanylate cyclase|EC 2.7.7.65|Legionella busanensis|TrEMBL
MKEQERLLAVFFSILLILLGSTVIFGWLAHIPKMVQLIPGLVGMVFNTALCFILTGLLII
NSNYFFKNQRFTQNILSSIIFFIALITLSQDLFHYNLGTDQIIIKPWLEDPNPTPGRMAP
NTSLGFLLISIIGFIMPYGRHRKAAIIIQLLTVLILLIALLGLLVYSLKLEFIFRWYSYT
RMAVHTAIGFLIASFAWWATWASSKWYRDFYQGQEDKKIILITGLILLSISMIAGLGGIA
WLTYMNIAAVEQALQDNLQEKTSIISNEINSAKQTLTKIAFNPLLLNEIKKSPINITRLG
EALNYLKPNNLVRFQLKDKQGEIIYSQGHLSSEPPLSIPLNFPEKINLIWKNGFWLKGEF
ILNAGVPQSKLATFIGEVPLTGINRIFKDNQVPNTSRELSMCVASSSKLATCFPNRFTQK
VFTVDLYTNFKPLPMSYALARLKGVVHASDYRGHQVIAVYNYIPHMPLGLTLKIDTAEIY
KPIAQQLKYVLPVAILFICGSLIFLYLQILPLVRKVVFSEKEAKEARERLEENVALLKKR
NKEISLLRELSAHLLSCQTLKEAYRLIANCATHLLPHTSGVLYLSYSSTSQELISVLCWG
DIKLKIKALKKDSCFALAQQTSRVITNITDIPICEHVSPTDLSYEPLFCIPLSIQGTVQG
LLYVKQNNKQKINPHECENQRVLLGILSEQIALGISNIKLRIELQEHSFHDPLTGLYNRR
YMESTLQDELLHAKQHALPLSIVLLDIDYFKRVNDHFGHDVGDAVLVALAQLLRSSIRSH
DFACRYGGEEFFFFMSNSSKEVAIERAEQLHKKVAKLKFPRYNLGPITISIGIASYPADG
DNLIALMKAADIALYFAKSTGRNKTISYSPKLHEKKLTK
>A0A8G1NWI8|diguanylate cyclase|EC 2.7.7.65|Qipengyuania aurantiaca|TrEMBL
MSRQKSAGYFGWPIVFGLAWLACALVALDLTQGEDGIAAVWPPSGIFVAALLLFGPRRRR
MTTLYVAAASMISNVWAGSGVLDSAGYTVANLAEGYLVFYLMGGNKASLTPLSRPLNTLR
FAATAIVAGCFSGLMAGLLSGNMTYPFLSSWTSTVSLGMLVVTPVILFIAQDPQDQRALL
SMRSLWTMMVVAILSVAAFGQADMPLLFLPVLGIAVATAIMGLSGAATAVTIIATIGSIL
TAFNAGPVTLFFSTTEEQVLFFQLYLVALLGSSMPLAYLLSEREHALARTAESAALLEAA
ERAAKVGHWRFQPGDNSARWSREALRICGFDESESPGFEQWLALIHPDDRDRVRAFVVEA
TSQALPFAFETRMVRGPGDIVHIDCRGQAEADSHGKVTALFGTMMDVTERAETMAQLEIA
RAKAEREAAEVRMLAETDALTGMPNRRCILANLAEAMDAHEFQGEPLTVAMVDIDHFKAI
NDEFGHEVGDTVLKQIAAILMDELRSDDSVGRMGGEEFLFVFPKRRADELDPRCDRIRER
LAAEEWEHPMTVTLSIGVAELQPGLDERDLLRAADKALYEAKRAGRNRHTVHAA
>A0A087DIK2|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium scardovii|TrEMBL
MSKSIEASIVVVDDEPSIRELLVASLHFAGFEVATAASGSEAIEVIEKTQPDLIVLDVML
PDIDGFTVTRRIRQEGVDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPVIRVGDLEINEDSHDVSRAGQPIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVDDGNGGKRKVTPLIETKRGIGYMIRE
PRAAQGA
>A0A087DIH8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium scardovii|TrEMBL
MTQDNGAAAESDDEKLIMIVDDDQALGEMLSIVLENEGFRTVTCLDGQRAVDMFPTIRPD
LILLDVMLPGLDGIGVARRIRETSNVPIIMLTAKSDTLDVVSGLEAGADDYVAKPFKVAE
LLARIHTRFRIARPAAAGGAESAAEVQHVERGPIVMDRLEHTATKHGRDLMLTPMEFELL
FLLAASAGEAISRATLLSKVWGYENSGDTRLVNVHVQRLRAKVETDPENPQIVQTVRGIG
YKFVTPQDAG
>D2ZE63|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus ATCC 35316|TrEMBL
MVLIFSTLLTWREVVVLEEAYVSSQRNHLEIVANALDRQLQFSVDKLLFFRKSMNEALST
PLAFGVLQDAVSRFNALRTKPFWQLAVDKSRTLPVNGVSDVFVEKTTLLNRDNALLNHEI
SAALEVGYLLRLASSSSHRESRAMYVSRAGFWLATDAPAKTTDAISRYYAFVTQPWFTGQ
SERENRAGAVRWFYASTPSAVEPHSTITASVPVYHDRYWYGVIALEFTQATLRRLLMEAV
DDRTEGEYQLYDTRLKLIASSELSSATVNQFDAAELAQIAKAIEGDTEGGLRMGSRYVSW
VRLGHFDGVMLRVHTLDEGVRGEFGSISIVLALLWALFSAMLLISWLLIRRMVSNMYTLQ
HSLQWQAWHDPLTRLHNRGALFERANRLARECQAQSRPFSVIQIDLDHFKNINDRFGHQA
GDKVLSHAAGLIAGGLRPCDVAGRVGGEEFCVVLPGLALPQAAAIAERIRSRIDSKEILL
KKSTTLRISASFGVSCAHEKGNYNFDQLQSIADLRLYQAKQRGRNQVVWQDHDKK
>A0A7T0JK38|diguanylate cyclase|EC 2.7.7.65|Methylomonas sp. LL1|TrEMBL
MFKLDEAKLQAVLKQLHQAIYNHERWHNDLIRTIICQQPHDHHDMAKDAHRRCRFGQWYY
NDVPTEVRDHQAFLAIRTEHKHMHQLATQLLATAATKAAIAPHDYDAFANALDRLRLEIQ
TLSREIEESLYNHDPLTGALNRIGMLTSLRALHELVKRQVQQCCIAIMDLDHFKVINDSY
GHAVGDKVLSASVRYLMDHLRPYDKVFRYGGEEFLISLPSTDLKAGHTMIERIREELGKP
PLAFHGSKPIPLTVSFGLAMLDPEVNVEETIRRADKALYAAKSAGRNCSRKWDAVNSTPL
A
>A0A8G0TFK2|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MSFEDSLEQLRRQFLHALPDKKKQIITLWISLRKNWDAHMLSAVYREVHNLKGSSETFGL
SDTKHIVNKLELQLKGLLNAPAPELPTIKSLDSLFHQLLQNNRRGQPSAPVVEAQMQQSP
YKPSKARHEHHIAIIEDDNNVGVMITKQLREFGFSVQHFLDFTSFLVVQNESPFDLILLD
LILPDWTEEALFEAATEFEKNNTRVFVLSSRGDFDMRLLAIRANVSEYFVKPAETTLLVR
KIHQSLKMSEKQPLKVLLVDDQQSMVDYFSSLLRSHGLMVKGLSSAEQVLPALEQFEPDL
FIFDLYMPEVNGLELAKMIRQLDKYTSSPILVLSSDDTMQNKVSIIQAGSDDLISKQTAP
SLFVAQVISRAQRGHDIRSSASRDSLTGLLNHTQILVAARRCYNVAKRINSQVCIAMFDL
DHFKKVNDTYGHAGGDKVLLAFAHLLQQSLRQTDFTGRYGGEEFMLVLPDMQKPLAIAKL
NAIRESFSHIVFVEDGVEFKVTLSGGLVFSDECEEFQDCLLLADKHLYEAKRLGRNQLVV
SPSEQD
>A0A8G0TGP4|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MDFRVLVLSLLLWLIPFGASAIDQLDELTELVYQYPSKALTQITALEKQFTTRATSDINR
LRLSVLKCQNLLQLGENEAAINVAQLGEANAKQLKLDQVRPYFLICQADANLNYNNIQNA
LPLLDSAITLARRYQQPQALVDALRLRGQLDTDTDNFSSAIEDLRLAIDIYPDIHTQTQN
WVWPPQAYIYAAMGNLLYATHDFPQAMYYTNLGIQSPDAKGKVLHIILRNAARIALDNQE
FDYSDQLEKQAKALLPELGSPLELAYSYAILASISLDKGRIDAAEEYLSIAINTFKKHNQ
QLAMMRSTRLLAQIRFAQHQDDAALTLMNHAIEQAENLKQYSDLKGFYGIMSDHYLEQGD
FKQAYSFLLKRYRAAELANQGMNTARILQFKARLNQQDLQQDQTSPAPEKASILQELNLD
WAYSTLFLIAMTLLGGAIWYLIDKQNNRAPRIEGEEPAETLLQQVTSALNSAKQGNYPLS
LLLFNASQIRQVDLPPLQDELQHRLREQDKLIRYSMDEIVIILPHTSAAGAKKVVNQLVA
CIQPWQGSSKVNIGIAAMQHFDTLESLIKRASINQLGKVKISENNPNHYSPAK
>A0A252EPM5|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MANSLDFDQALNELDVLLQSDFSAAQKKLAEYETAFSGLTPTQKGRLRIDRAISYIFVSE
YAKALDDLRQAETLITSPELLASIYSYQATVYIGMRDYDKALSAVAKALALVVNIDDVTI
KRHSYLRIANIYSEMDAYSDMGLYANKVLQLAQEADVRDICHAKLLRAIYLLGVKSPDAF
DAFEDSRQYCDAKQFPLLATMSMKGKGMVLQERGDYLGARAILLLALKGYEAFQFQLEIS
HVHALLAENYFATGELVQAKSHAVKVLTFPDDNSYIEHKHIAYKVFAELMAADKQFEQAY
EYSRKEQHYNQLIFDESKMKTLAYQAAKFNADEQAREINLLNKERELYIAQQTVKEREYT
NMLMFITILVGGLFFLAILLVVGNLQKRRFMRMARMDALTGVLNRGAGQDLGENLFVQAA
ARGGDFCVILFDLDHFKRINDSYGHGTGDWALKKVVEALKPHVRNGDVFARIGGEEFALF
LPYANESKGMEVAEQCRSRIEAIDTHLSGHKFTITASFGVSGMTKEDLSLDPLLHRADMA
LYAAKSNGRNSVFCYEDALASDKRATNITSQLARQ
>A0A1C5TAN9|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MDYRKKKNLIWKGESFLFFVVLLVFGAIFAAIHTGGLIQKQDSVQLLNKGWYYIKDGKKQ
EITLPAEIPAKTGEKLILYNESLGAESRGMTVVSTGAQYDLVIRLNGKILYEYKEAMFSK
NVQMRSKVQCIAALGNDTEGKVLTFSYSAPQRGKYVIEPVCIGTGSAIAWYQIRKAAIPL
GAATIMIVLSMIALCICIYMRIRQMPDRRFRDVALFLMMCSIWLVTDSSLAQSYSRCPEV
LCLISFYMFMLLAVPMLRFLQNIGNMKKYRLLDLGIFTFYLNAVLQGVLVILGAFEFKDM
LFVTHILLFVWVLISAVLLIREYRKHKQREIHLLLIAYIIVGASGIIALILYWLFEISYY
GSIFELGNLVFLVLVIADAVMMMADNVRYRLESQAYERLSREDGMTGLETRANFEKKLES
ISADMGRYRDILLMYIDIDQLRVINEEYGRAAGDEMVVISARCVENVFREKGTCYRIGGD
EFAVLVYEPEVPDEFWPERLKEELRNIGRGCIHRFSLSLGYSHLRNKDGSLKSIGEWKYE
ADRKLYENKKKEDLKNGVY
>A0A1C5LPZ1|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MFKGLCRKFYALLRKEAVHENEPQRILFLLRIILLILGLYFLIIPLVFCIVGPKTEVWTG
YIFAAMAVAAFYATYRLKVHTSVLVCSGLQLAWIIVFVVLYGWDCGIQHLMFEMLVLVYF
AVYNSLVYKVSYTVVLFAVRFSLFLYCRVNISVFALTETATVVLQIINTIVTFVLMAVAC
SMFSSNVESAEKKLVLYNEQLKKQAGTDPLTGLWNRRQMIQYITEKRRKEPVMAFTIGMG
DIDFFKRINDHWGHDCGDAVLVWITQHMSRELGEHAKLCRWGGEEFIFFFPDMNGDEVCL
MLNTFRMKLGNDLFDWRGEWIPVTMTFGVEENDFKSNIDTLLKNVDAKLYMGKEQGRDRV
IY
>A0A5I2X5N2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ank|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0T9UDI5|diguanylate cyclase|EC 2.7.7.65|Yersinia aldovae|TrEMBL
MPYSARINTRRSGLSFAKRTYLPRAFGLGIGMFCVASVLYTQDTPLWLWLLLAVYGLIWP
HIAYLLAARSEQPFEQETTNMKIDSAIGGVWVALMSFNALPSIVILSMMSMNNIASGGKN
IFYKGLALQIACSLLTSWLFNLPFKPETTPTQVYACLPMIIIYPSLLGLVTYRTAKRLAE
SKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITILAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLARIQIRLGEIIF
KHAPSLQLRLSAGIADYRHDMVNYQQWLKAADAALYLAKDNGRNRIELAS
>A0A517NF92|diguanylate cyclase|EC 2.7.7.65|Rubripirellula lacrimiformis|TrEMBL
MPIATTVTPLIAGVVLAMFVLLVGGLIGFRIGQRKYARLSENQLSEGDRERLVQLLAELG
SWTNEYSGNVSDYQDQLGRLSDAVEKGGNSSSTDLRVMTLLQQIMQTNGDLQTRLDEAEK
QLEKQTRQIASYLTEARTDGLTGLFNRRALDTRMEEVFTAYRSGGRTFVIALIDIDKFKL
INDNYGHQAGDQVLKQLASVLRTQLDGSLMVARFGGEEFAAIMDGPLRVAAATMNELRKH
VADHPMQAGTKQIKVTISVGLSEPREDVIVAPVLRRADEALYAAKNIGRNRVYYHDGRDA
ILVGAPETARSDE
>A0A8G0X7U8|diguanylate cyclase|EC 2.7.7.65|Bacillus subtilis|TrEMBL
MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYFSTLCVSLTPSSSDFVT
KLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEGLPDVVASFLNQSMKQERL
YNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSLFEFSLFISHDQDQCLGIPAK
ELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQGTYGVLKAEGTGDSFLTDACLD
EMSLLANAAGKAFENAQLYEQSKASIANLELINETSRRLNQRLTLTDTMNDLAVRMAESF
QAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDFYNELKEKLYEGEKGVFIGNGQSVFGK
AGYGSLMAAPMIQNDRLLGFAVLLKQELYAFTFEMYKLFQALIHHATLAVTNSMLRDRLE
HLVKTDQLTELYSRAYLDEKIQYSMKIHQKGVFILVDIDNFKNVNDTYGHQTGDEILIQV
ASVIKSNIRKHDVGARWGGEELAIYLPNVPVAVGKRITERLVYAVRKNTKPEVTISCGIS
CWTTETKKSLKELVHEADEALYSAKRSGKNRLMIHDSIK
>A0A1V5VZU8|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MFSEDKSLLTWVVSITESRDIEILERIMLKTAYELIPCEGVYFFRTDPVDMSIQSSSAYD
GEGYVYSCDNEVFEYIEDLRESMMLSYSDYSITSVDNSLHPIIISPVNIMSSSVGFITLD
FPETSSESLCVLEGIVRMYQNYISALLDRDRDELTGLFSRKLFEEKVNTFIRINKRLKDK
PLKGNERRTYAENDLYWLGIIDIDNFKSADDNFGHIAAEKLIVIMGKIIQDFFRASDMKF
RFDEDDFAVVIKTSDAQRALLVFERLRKTVENYNFPFVERMTVSIGISMINMEESSSFFI
MRALRALHYAKSHGKNKVFIYEDLVDRGELPREAIIKKDQIKE
>A0A840SXB9|diguanylate cyclase|EC 2.7.7.65|Amaricoccus macauensis|TrEMBL
MLVVDDVATNRLLLRAKLSSAYYDVVVAENGAQALQMARSEQPDMVMLDVLMPDMDGFEV
CEALKAREETAHIPVIMVTALDTPEERIRGLDAGADDFLSKPFNDLALFARVRNLMRMKM
MFDELRLRDMTSRELGIADFVGDIGADMDLDTCGPILLAPPSDAQGALWAEQLSARLAIP
TIVTHSEREATNLARMELPDCFVVHQSLAEGGDGLRLVSALRSRPETRQSAVILVVENGD
VHVAAKGLDLGASDYIESPFDISELIARIRSQLRRKRYSDRLRSNLRNGLKLAAIDPLTG
IYNRRYASQHVLRVMERAHDTDGVFAVMMIDLDKFKSINDRFGHDAGDAVLKEFSRRLQE
NIRGVDLVARFGGEEFFVAMPDVDQTAAAAAAERIRRAIEGGSMPLPDGGAVEVTVSIGV
AIATAADTDPEAIIKRADSALYRSKEAGRNRVSFAQAA
>A0A554WLS9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MDTVAAWAVGLAGASRTWVRALLTVGVVVWLGLPWLAQPAHAEVALRTPAVDVAMLQGQA
LWLRPLARTLREDAAPPQPIDPLQRLRADLPWQPVRDLEPVFGFGFDRQAWWVHVALQHA
GPAPAALVLEAAEPLIDDIRVWVFDRAHGTLVTQAHQGDRVVGAVRPLQHRHLALPLTLQ
PGQQVDVLVRVFAFDGEHDPLPLRLWSASAFFSHAQLEAWMYGAYYGALGVLLLYNLLLW
AGTREGHFGLYALYLGSFLLWNLTYRGYAMQYLWPDAVTWNQIALVGFSALIYATMALFA
WRLLDLPRRTPWLYRLQAVLALAALAHAVWIVADPLAATFATLDRVGLAMFAVLLLAALR
VAWQGTRVAWIYLAAQGCLLAGAGVYYAIKLEWLAPGPLALQALNLGSVGEFLLLALALA
YRINQLKAQRDDAQGRLMDTLQQMNQRLEREVAQRTEQLTQANQALAELAAHDPLTGLYN
RHTLLERLTEELARARRHPQPLGLLMLDLDHFKPLNDRGGHAYGDHVLRQLGALLHPPLL
RTTDRVHRVGGEEFLVLAPDTDPDGLQALAERVRSAVHAQGWPHPDAAIGWVTVSVGATL
SHPDDTPETIFARADQALYEAKRGGRNRAAYA
>A0A8F9UXR7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MPVPIYDPHHPPGGTLKRLPLLKAAVAFIATVFLCLCGLLYLQLEQSWRHDLMQAEVNST
NLTRAIAQQAEDTFMEADLVLMSLSEWIQALGDGPEQQPRLQGIFARRVQALTQLSGVFL
YDRDGQWVVSSFGDSPHGNDVADRDYFRFHQQNASLLAHISPAIRSRANGEWIIPISRRL
NDSQGNFQGVLMAGIKLAYFDQFFTSFNIDEQGAMFLALSDGTLIARRPFEERQIGASLA
RGEIFSKYLPEATTGNAMITSIVDGVTRLYGYRQLQAYPLVVAAANSKDSVLKGWYASAY
QSTAIVALVLLGVGLFGWVFVQQVRNNERIEADLREAQEALEVIATHDSLTGLANRRLFE
RALTVEFGRGARQRSPLSLVMVDIDYFKRYNDTYGHVAGDHCLTEVAQALKGCCQRKADL
AVRYGGEEFAVLLPDTDIHGALAMAEQIRRSVMQRNIAHSGSPVGCVTVSLGCYAFVPTG
RDSIEMFIERADAALYQAKATGRNRAMALAADHVGEPLQRSDR
>A0A1J5N416|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MKNRRTTPEERLRKRVREHAARLRDGDDPVEFWATFCEALLAESAEPGPAAMRGADGGSA
ASLRASRLNTLFLSLRTPVLLLDADFAVEVMNPAACELTGAADVEAWCRGDHAPVPLKEL
APWLEGPLEAEGLGVEGVEACRLDVPVVQRHGERHFSVAVSLAADFPDRRTGYAVVLDDI
TDRVEGERELAGERNRVAHYLDVIGAMVFTLDAAGRVDMVNRTACRMLGYAEEELLGRDW
VDILVPPPQRDAIRDCLYLVLSGQVEEEDERSFPVTTREGFRRMIQWQSQVLTTEGGLPV
GMLLSGTDITEQRVIEETLAEKELWLRSSFVALGEAVLILTPEMTILDANPAAEAMFERS
QADLQGEPVSGLHVNAGHYEDFLARSKAAFEAGERALFELPLKRRKGEIFPADQSVSLIK
GDDGATLGVVNVIRDISDRKYAEAELKRSEEKFRRIFETIEEGYMVTDLEGTVLMVNPAT
CRLLQFEESELVGRNIDTLYRQVSERVGFREALQAKGAIRGLQMTARRKDGTAIVIEANA
HQVLNNQGEPVAMEGTFRDITRRIEAERVLRESEKQYRAFFENNHAIMLLTDPKSERIID
ANPAAADFYGYPIEVMRTMNLSQINALGRDEMFSEMRRSMDEGRTYFIVRHRLAGGELRD
VEVYSGPIMVQGAQRLYSVIHDVTKRIELEQEMKLLATTDALTGASNRHQFFSLGGVEVQ
RAKRYDLPLAVIMLDIDYFKSINDTYGHAAGDQVLKALSGAVSSLLRAPDIFGRLGGEEF
AVILPQTGIDEGVEVAERLRSTLAGLAVEVGEDTVTFTVSMGVTRVSPGDKTVEEVLNRA
DEALYKAKRMGRNRVVRG
>A0A1V5HHE7|diguanylate cyclase|EC 2.7.7.65|Lentisphaerae bacterium ADurb.BinA184|TrEMBL
MSFTVRRALVILLTVGPLLALALLVCIAPSFLVPPARRWWLSVAAPGACIAAGVLAWRFN
LTRFTLIAAFLVVAHACLARPGLPAEAGEGLRFWFSLQAPVLVAAFFLAEECGLLNPRGL
LRLLLAVGPAAVAGAVFGSHGDPMLGLLPRGLTAPLAPGWLPVPAVGGLATVIALAVLLA
PWPSREPRCGGMLAAMLLAVVAALCVMAPDGFAWRALPLEQRPGAAAAAVSVFFLAAGGV
LLAAGLELAYGQAFLDPLTRVPGRRAFDHHLRTLGATYTIAMVDIDHFKRVNDRYGHDVG
DQALGFVAARLHRIPFGTAFRYGGEEFAIVCPGRRMAAVKPLLDDLRREIAGADFHLRSA
DRPARRPRRRAGVSKPRATESRLRLTVSIGVAEARARDARPEDVVIAADRALYRAKENGR
NRVESGR
>A0A1X3J1X2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA447|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>Q8EHZ9|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MQNDGYTSLGRFIDLLLDAICVVDKSGRFEFVSAGAERIFGYTSDEMIGMQVLDLVLPED
RERTLAAAEEIMAGRYQLDFENRYVRKDGSIVDILWSARWSEEYQQRVAVARDITKHKLA
ERRQAALYEISEAVHVAEDLLSLYSHIHQIIAKLLPAENFSIALYDQDVNQLDFPYSVSV
TDKTSAHIGNINYFAEQIIQTGESLLFCPMSNTLSSPLNSTVKDSHISWLGVPLKLHKGV
IGALIMLSTPGSRTYTSQDCELVEFVSSQIAFAIERRQMLARLEQIALYDQLTHLPNREL
FYDRFQKALSRSHRESSYFSLLYLDLDKFKWVNDTYGHGVGDLLLQITAQRLLGCVRASD
TVARFGGDEFVILLERVDSAHNTLLVAHKVLEALNQPFELTEQQLYVFPSIGVALYPEHG
KDEQQLLSCADAAMYKAKKNGGNRIELGYHGLRGKHVEVFTS
>A0A380H772|diguanylate cyclase|EC 2.7.7.65|Staphylococcus saccharolyticus|TrEMBL
MFEAIIYNISVMVAGIYLFHRLQYSENKRMIFSKEYVTVLMTLVSLLLAAYPIPFQNAYL
VHLTFVPLLFLGRYTNMIYTLASAFIVSLVDVFIFGNSIIYGITLVVIAGIVSAIGPFLK
QNDIISLLILNLISIIILLFLALFSPIYDLIEILVLIPISFTITIASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNDVSSKAEEKNQSLALLLIDIDGFKDVNDNYSHQ
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVIIRNYTLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTQDDRKSQRKVFKDADDMVHVAKSEGRNKVMFNPIVKL
>Q320N9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MPVHLKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGRA
DRAMYEGKQTGRNRCMFIDEQNVINRV
>Q320K9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A259UK35|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MMRYVHDIMIKKYVVVNAVDGLRHIQSLVLENNCEGFPVMEDNQIIGILTYKDLLQSHPN
RIAADAMSDHIVYIDAHSSIWKAKEVFDANHTDLLLVLDNKELVGIITKSLLEAELGKHI
DLLTELPKSDFIYYNAVRFIESNQELSFVFFDVNNFGLIDKEYGHITGDIILKELGTLFK
TNLPEQTYVSRFGGDEFLVLTPYYIDKCYTFTQNLLKIISRYKFHKNIPVSVSAGIAERK
AMQENSQNTLRTISNLINLASLASTKAKKEKCDLCIATNYASRTFAG
>A0A220W7W6|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. SMR4y|TrEMBL
MNTRMSSLSPVRQTAIISAIAALLSVAFTGTVYLLFFGMDERFWSAINMSFLIPWAITIP
LGLYMSKQRFKLVQLTNRLKETQIKLRQANKALEQRVNIDGMTGLLSRDSFFSQLDALRA
DSEASVLMIVDVDHFKKINDNFGHLVGDKALVLLGDIFRKTLRKNDVVGRIGGEEFGIFL
PDTSASEGQIIGEIIRHEIENTIFEPHHKMRHVITVSIGVTDIAPHQDRAALMGNADTAL
FTAKRCGRNQVVLFEPGMSAKPRPVHDRVQDFKPILVQSNFR
>A0A564WAI5|diguanylate cyclase|EC 2.7.7.65|Blautia luti|TrEMBL
MQTNKKSKNIIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREVKLE
ITGYHNEELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKKEIEAARN
KGYENTDIVNMSEIYFSMADETVSSAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
RAMQMAMQNRLLEQKAFIDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLIINFAKLLRSVIPEKDFVGRYGGDEFIAVIYHTSEAKIKEILKSLNREKDR
LNSYENQIPIDYACGWALSSDDMSCTMQMLLDTADAYMYKNKQICKKYN
>A0A7W3DWA5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00013|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A379C0V7|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MRWADALDGAVAPTLTRSQIEAMLAGLADALAAVVLGTAELAVAREAAAVLIAANYRDAV
AVSRSVVVICRDLVDDLCPAHSGPEYERIRDRAVLAAAEFAAGCTAALRSAALAEQEATL
VATLAAAQEAEAKRQLSEARFAAVFAGASVGIGTIDVMGNVLDSNAAMADMLGLPVEVMP
GRSVAELLGPANIGYAFDELQRLLSGAADRFRLETDHLRPDGTVTTIDLSMSAVRDNTGQ
VRFLIGVAVDVTERKQLADRLWHDANHDSLTGLPNRTLFFDRLANADPPIGVCYLDLDGF
KEINDVWGHTVGDKVLRVVGERLQGAVVPFGGLVARLGGDEFIVLVEKCSCAEQLAKVSA
ALAQSLVQPIAVQNHLVTVGASIGTVFLDEVPAAPDELMHAADTAMYRNKAAQGARPLRF
RER
>A0A0T9P9L7|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPETPAVTLPIVMITFISLSAAGY
LVFISKNYADKLNLFSITMGVLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTGPSALTVIFLDDFQNIFRIIFTVMLPLIGFSLHHLMLRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYATQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLASSLKAADEALYRAKKDGRNKVAFAKDELSKFESSP
>A0A178XDK6|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MSDAWLVGRARELIAAVQRQEHENQLEIVKIMDELLEETLRRGEPTLVAQLLRASAFSRL
VTRGLAAEAEPRLDEMLAHTRRHGLSLLRADAHALRGRRLVLAAQEDAALTEIARALAIL
DDSTIPDRQIGVRNWNRMQSMALIDCWIVLNQLGVYEAAEEVIGRAHQAIRESASPHEIT
LQLMNRVKMLLGWGLRLERIEQYDESAEKFRTAASMAVAAEGPFAESLFPRKIGVSAVDQ
VGVLAAALALPDPSAEHVERLQGMHLGHHYPHEQELVAIALARCLDAAGRRSDALQVLRE
SRDVLAEDVSQPSMRLTLSRELARLDPEAASQSLIDYATALETEMWALRESQIATLNARR
EHERLSAEHGAITQQALQDPLTGLPNRRALDERLRSLASSADAQPLAVALVDLDGFKGVN
DKQSHAEGDNVLRVVASTLRDALRGDDVVARYGGDEFIVLLPGAPASAAKMALGRAAKSV
ATLPHHLSHGVTLSIGLVSLRPQERAEQVLARADAAMYEAKRGGGNQVASANSMAGDGMG
GWPGETAPTDPAWSAEDPT
>A0A6A7SM40|diguanylate cyclase|EC 2.7.7.65|wastewater metagenome|TrEMBL
MVLFDIDWFKSVNDRFGHPVGDRTLIELTHRVAAILREADQFGRWGGEEFLVLAAHTDLR
GATVLAERIRRAVADAPFPGVGPVSVSLGVAEMRFGWTLAMLTERADAALYEAKATGRDR
VVVAPA
>A0A840ZG28|diguanylate cyclase|EC 2.7.7.65|Methylorubrum rhodinum|TrEMBL
MSARVLIVDDLYPNVRLLETKLSLEYFDVVVAMNGPDALAICERGACDVVLLDVMMPGMD
GFEVCRRLKSNPDTAHLPVVIVTALDQPADRLRGLDAGADDFLTKPIDDTALMTRVRSLV
RLKAVTDELRSRALATRALGGIDPLALAAADTGEGANILLVEDRASAIDRIGTALSQHHR
VTVETDPHRALVLAPDGGFEVALVSLDLEGFDGLRLCSQLRSLDRTRNLSLIMLGEMGEK
TRITRGLDFGVNDYLLRPIDRNELVARVRTQVRRRRFTETLRGALQASMELAVTDDLTGL
HNRRYLDRQIGTVFGDAMLHQKGLACLLLDIDRFKLINDTWGHEAGDEVLRAFAERIRQQ
VRPMDILARYGGEEIVMVVPGVDLPEAQAIAERVRERVEAAPFAVQRGTRDIPVTVSIGV
AVRRSTDASPADMLGRADAALYRAKSAGRNRVEAAAA
>A0A8G1JR38|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MPIPIHDPHQAPGGTLKRLPLRKAAVLFIVAVCLSLSGLLYLQIEQSRRQDLANAQVSSA
NLTRAMAQQAEDTFLAADLVLTSLVDWVQDDGYGAEQKPRLQKTLARRVQQLEQLHGMFL
FDREGQWVITSFADLPRGHGVADREYFKFHQQNVSAVAHIGPAIRSRENGEWIIPISKRV
NDHAGNFQGVLLAGIKMSYFDRFFKSFSLDDNGTMFLGLTDGTLLARRPFDESLIGTSLA
KGEIYQKLLPNAAAGTAMIDSVVDGVTRLYGYRQLESYPLVVAASSSRDTILQGWYDRAF
QSSVIVALVMLGVGLFGWVFIHQVRDGERIEKNLRKAQRTLEQIATHDSLTGLANRRLFE
RSLEVEFARGARQSSPVSLIMLDIDFFKSYNDAYGHVAGDHCLTQVAQVVKNCCQRKSDL
AVRYGGEEFAVLLPDTDINGALAIAGQIRRSVMDKHITHSGSPTGYLTVSLGCYSFIPLG
NDSPELFIQRADAALYQAKNAGRNRAAVLSMDVGFGELLRSDR
>A0A0Q0ID28|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MDHAVSLAHSAQCLKKAIPLMVKYRMPVTPINYAIWYCYVQGSKPALNAELDHVIAEQQT
CTQNRAKEIFDKHLSEDDLVFFQEMADRFHGTMQQVQHDISVTLDHSKSFTTSLVDSQNE
LASLVNVNSFNEILGCVERLTDESVAMQEYAREFQTKLALAYNEIKDLKEALNLSQEAAD
TDPLTGFFNRRKFDDDIQKFCQNYSEQADDSVLAVLIMFDIDHFKRFNDDFGHQKGDEVL
KLVAKKVSQNISDSLNVYRYGGEEFCITGYFDSINDIMVFADKIRLDIASLTIRKKDDIN
SKRAISASFGLAILRPFTKGSVLIERADRALYIAKTHGRNRIEIAPDI
>A0A380AA49|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MDLSQIWTDESEYRRVALKVSAWTIFCLGVLFSGFNWYMGLPLLSLMELAMAGFCLLLLY
RLPTTSRLKEWSLCFLSLLFFIVLLESELHFSLFINVGLCLSTLWIMSHVFESKRAEMVE
RLQLMAALDPLTSVYNRLHLEPVFNLLQQQITGRLALLLVDVDHFKQINDNLGHDAGDRV
LQQLARLLQEFVPSPEHVFRVGGEEFCLLLPVADMAEAQRLAESVRAAAESLPLDLATAQ
GLSVSIGIALSPELSSRLKPELRQLYRQADERLYQAKLNGRNRIEPPQS
>A0A0Q0MJ22|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MMRQLSIICSFFVMFLCEAQEQTRLPLSDYFSETWNTRSGLPHNSINSVTQTQDGYLWVA
TWEGLARFNGQEFTILTRAHINNLPDSGLRALTPTQSGGLYIAGSRGGISLYQHRQWDTQ
RSASTMVNHLIESADKSLWLALENDGVFYREHNSDTDLAIIKNVSAYRVIEDSDGVIWAA
TSAGLYKIDNKIPTLMTPHFGLPNAPVYNLLITRGGSLIVGSEKGAWIKINSQFRPIHEQ
LANESISSLLEDNHGDLWFGTINKGVFRLSPDGVEQLDAKNGLPANRILSLLQDRENSIW
IGTNAGLFRLRESPFSSWTHKRGLAGDYTRTVLSHSDGSLWVGGSSGLNIIKNNRAILVS
GSKQSNPYSILSLHEAPDGSVWAGTYTSGVLKVVNNTFTPFISRSTGLGSNEVRALLFDS
KNRLWIGSAMGLTRINEDGSLEQFTNKKELPSGFILTLSEDNAGNIWVGTGNGVVVFDIV
SEHFTTVEFPREFSAKYAFGFYIDDTYTWMATDRGLVRYELKSGKMAMLGLEQGLPIDKL
FQVVPHNGSFWLSSNRGIIQIDKNHIQQILDAPANAKTPVLNYQLYDEGDGMLSAQANGG
STPSAVTHHDGSIWFATAKGVSTVKPARLKASTQIALPTIIENIFVDGKPIALPLEGESV
FLPPGVSRLSFHYAGLSFIMPQRLNFQTQLKGFNDKWVNRQHMTGAEYTNLPPGEYTFMV
RASYPNAHWQDNQQAVNIVIQSFFWQKPQFKFAIFVLFLMVIFAIYKYRLYHYKKIEIEL
TNRVEKQTQDLQTQANAFAYQATHDQLTDMPNRRAFDSWLAHNFATYKQQNRPLAIAILD
IDHFKRINDNWSHIVGDKVICTIADLLKDGCQENQHIARWGGEEFTIVFADKTAGEAKMI
CEALRESIAQHDFSAIGEGLSVTASFGLSDSTNVGDYDRLLSRADQALYKAKNSGRNCTE
II
>A0A379Z3Y9|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MNELHWLIDMVQTIEVGLVVLDREYNIQLWNGFMENHSGVSPNDIKGDNLFERFPDLPAS
WLKQKMESVFLLKNRAFISWEQRPYVFKFKNYRPITGRAEFMFQNVTLLPLASLTGQISH
ISIIIYDVTDIAINKLQLKSANERLEHLSQTDGLTQLHNRRHWQLCMQREFDRHSRYGDP
ASLVMFDIDHFKRINDSLGHIAGDRVIQHLSHILSQNLRETDCAGRYGGEEFAVVLSHTS
AEDARSFAERLRSQVESSRFSFNGQPVPFTISLGICDLSDEVENSDQWLANADQALYQAK
VSGRNCVSIFSD
>A0A1V5HM66|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA124|TrEMBL
MEILFKILGIINLDIKTMIGILFWGNLALAFLILRYYLYHEAGNEKTLIKWFGIAKILQA
IAWFLLFMRGDISDIFSVYFGNILLFVGFYLDSLVILKINTKTKRLWFQLQIVWLALSVI
AFVFFEIWLGTGNIRIAIASLSVFCIFVTPNLLNITNKLSSRFQKFIGFTSLLFLLLLLM
RALSSLFNEDVSLFTNNVLQSGTFILLFLLMFVNGMGFLLIMYERSYELVKMSSNLDPLT
KIYNRRYFMNKAEAYYHRALGEQKSLSFLFIDIDFFKKVNDTYGHLFGDEVLKMVAKAIS
ENIRPLDLCCRFGGEEFLILAHETNNDQAVIISNRIREVIQKMVFLENPEFKCTVSVGVY
SGLPDSTQNIQHFIDNADQALYKAKESGRNRVVSF
>H6RKS4|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MSRGTGSKPTKGRTTGALVLSGLLVGVMGVLGLVSTHSAGALAIDQHREDRVDQTRVLGQ
LTAQTVRNAFHQLAAVLALQDEDGVPPFSAEPGNGPAADRDTARVRRIVEMSAGAMELGA
AVFNTRGQVVASYSPTGASASPTDPGFRPLVTAATDPGAGRIPISGIVTIDDEPALALGA
PATLSDGTSGLFVCFWSARSTTTEFFTAGEGEGWIVDAEGLVVGAPDPALIGTSLPYPAA
LQAARSGGDHGIVDTDDGGTDHVSAWQDIDGTTWTVLNVQTRDAFQGHLERASLRTELLV
LGMLLTTGTALVVLSRRRERAMAVIASTDELTRIHNRRGWFELAEQELARAARAGETRLA
VFLDLDGLKQVNDVLGHEEGDRAIASAAAVLRAACRSGDVLGRLGGDEFVVLLGDGADAA
VARRRVHEALDDFNAGSSAAFELRFSIGAEPWDPERPCSVEDLVRRADERMYADKQSRTD
RYDNLIRVPAKVPVG
>H6RUC6|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MSQTPHSPAAPRRLSTASPYDAQAALEQLLDRLRSSSGATRVSVWVHESTTELVIPFRQA
SCPGAQVPMHPALRIPAFVSDSPFLSAVIASRQPVVARADGRRAADRQLAEVGIRSGHGE
PLILDGEVVGILTVEPAAAAAPHLLRQVVPKLAAALAEAWTRRTEQRRLEQAAVLLGLIE
SAAQAQSMDHLLGSACRQLAELGEVERACIFLLEDGRLVPRMAAYADGRRDLATWQQFRN
APVALELAETVLRTGTPMTADRSSDLVAGWWVDSFQIASALAVPLGRGQELAGVLTLDST
QVRPFSEAVRRLAAAAGAHLGGVIEQARTSQARAASLATAQIVRQLLVDGSAVTGAAEAA
EVLARAVQRLAGTDRSAAYLVDADGRIAEVRHVDWPQSHQEVVATRLVGSPAAAVPLWRL
TSEQRSPVFVEDAAASDLLDPQLVQALDLSSYVSVPLLSGDRLMGLVVTGSVGSTRRWSS
SVRAAVRQVTLEGSLVVENAELRAAEQRRLAQLATEAHHDPLTGLANRRRFIEQVESAVY
ADGEPRCALLMIDLDRFKEINDSFGHSVGDDLLCLVGPRLQDVLHDGDLLARMGGDEFAV
LLPDADEQRAREVAEGLGAALREAFVLDGMALHVDASIGIALCPGHGRDRSLLLARADTA
MYAAKRGKHGYEVWAPDGTPASRDRLETLEQLRAALDSEQLDNHYQPQLDLRTGAVVGVE
ALVRWNHPDRGLLYPGVFLPLAEQAGLMRRLALRVLERALRDLQIWRSAGHDLSVAVNLS
VSNLQDVALPGQVEMLLDACKVPAGALVLEITEDVLMADAARSQQVMAGLRRLGVRLSVD
DYGTGYSSLSYLRALPVDELKLDRSFVTHLTTDARAAAIVRSTLQLSRDLGMSMVVEGVE
DADSLAALREWGCDVAQGYHISRPMPAERVLSWLTSRPVPAALKPGVRTGD
>A0A5J4E9M9|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg04|TrEMBL
MRAGGILRSMDQVRRRGHPMGRYGGEEFIVLLPGTGLPGAINCAERIRELTEKRTFVNDI
KVTVSVGVAQYRAGEEIKETIQRADEALYQAKALGRNQVCAEPRFDKPQGLDTHSETVLT
GRQKRLST
>A0A811G7N3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MDMLDSPFFELSPIAMWLEDYSEVKKQFDVWRQQGIQDLLSFLQQDESRILECARKIKLL
KVNAKTLELFQAQDFAHLSQNLDLVFKEDMSKTHITELVALWNGEMHFSNAAINYTLTGQ
RLDIQLKGQVLPQHEHDLSLLLITTEDITSYTEARRLEEQSRHLAEARFTYSPTSLWVED
FSRIKTKLDQLRKLGIEDFTTFLDVHPEFVNECAKEIIIIDVNQATLDLFGAPSKEVLFK
NIHKVFAEEMLQTFREQLIELWNGLLHHQREAVNYAIDGSIRHVLLQFTVFPDYLDDWSI
VQVALTDITARKKAEHYLEYLGKHDVLTKLCNRSFYMAELNRLERNILRPVSCIFMDLNG
LKELNDSLGHDAGDSVLRRMGNILNQLIQHTPYSASRIGGDEFVILLPGADEAALQNCLQ
SLQELLLVDNQFYSNQPISLSIGYATNHTDERMEEMLKRADLDMYRQKKNYYLDKDRRQN
S
>A0A2I8DIS9|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. AONIH1|TrEMBL
MSSSSSAIPVTPAVAGQACYLSASNAQAWQAVYQSVDAYTRGQVAAVVSDSATALVDAFY
STLLSDAEAGPRLSHEIVSTRLSSAMKGWLKGLLCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAIEQMSRAFMRDVNRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLH
HKGGVLFESAPALRQIMEAVARLDDVVLPGLMRGAEGQGAMPDLVRELQELVARIKHLLN
GLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIAIATRQHSAFSVLLLDIDHFKSINDQY
GHSGGDQVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGLEAAMPVAQKLGAEIRRH
AFSVSEAANLKITASIGVASFDGHPDYAYLIERADKALYRAKQAGRDQAVAA
>A0A4U9CYB0|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MAASGDEFAILLRNVHTEAEVQAQCALLSAQFLQPFNLHNGHTATLSLSIGYALAWEHTS
AENLQEFADQNMYRMKHQRLQQVQK
>A0A485BQR8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MWFSEEFTTSVLILPFVLICTAQQPFRPTELRRLIPVGLLAVSLAISIATGTAGSMGTLS
MILPALIWCAISYSLPTTCLLTLLAGVVEVLMVDQKAGGISLVGHVPLIISARLGIASIA
ISPVIVAVSVQAINTLVRQLSHQVRYDYLTRVYSRFGLYERLKELHDGERDTPLNVLVLD
IDHFKNINDTWGHDCGDKVLAAFAVRVQNVVGQRGIVARLGGEEFAVIMAGKPGGEGYLL
AEEIRKEIESMQVEWGSKMLSLTVSVGLSYGKAMRWNIVDIFDKLLSEADAYLYQSKKMG
RNRTSAPPVTAISQPLASI
>A0A485C7P7|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKSLWGRKLRRLSSPGHVVNFCFVVVLFFSTLLIWREIMVLEEAYVDNQHNNLENVAHE
MDGLLQFNTDRMIFFRNGMQSALETPLDFMILRKAEQEYISKRHEAIWSVALHNRRTLPV
YGVSDAFIDKDPTLSRDNTLSGNELMATLELGYLLRLTNNNRGFTERMLYVSRSGFFVST
EALTNTTQALALYSAATRSPWFTRQAQRTNPGRGVVWQTFPEEGALRDAQVVTASVPLDF
RHYWHGVLAMDFSVREMKTFLVNAAKGGQDGEYQLYDNRLNLIASSAPGNVLTLLSPREL
ETLSYAFSHDNKGGIRLLTRYISWEKLNNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGLFERAIAAAGECERGK
RPFAVIQLDLDFFKRVNDLHGHQSGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPN
TTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVSSSEDCAEVNFENLQSIADRRL
YLAKQSGRNRVCSTG
>A0A8F6Y8G8|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sanguinis|TrEMBL
MMEAPLAIPAPLDEERRLATLQAHALLDSEPEAEFDALVSLAAEMLGCPVAALTLADRDR
FWVKSAIGALPRQMPREVAFCDYTIQSSDVTVVPDLSRDPRFAVNPFVMSDPGTRFYAGM
PIRVPDLDGSPQAIGSLCVMDASPRSLSPAGEQTLRHLARLTESLIAARAVARRATAMAE
LSERQAADLRAKDRTVRQVERLALIGSWHAVLGTGQVDWSDGVYRIHELPPGQSFTVEQG
LSYYTPEARTVLRATIEHTVRTGDPFDIELDFVTALGRKRRVRVMGEREMLDGAPQGLVG
MFQDVTERHALETQLRRNADTDALTLLANRAAFDRTLEAAIAESSASGEPLALVLIDLDG
FKLINDTLGHPAGDEVLRIVGQRLRSDWLDGSFVARLGGDEFGLIVRDTTLLADTEALRA
RIETLLTITITIDGLTMSCAGTVAVTLRPEDCRTNRDFMHHADSRLYGAKRDRVGERRRG
DRRRAG
>A0A737KNF3|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPIWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A517PT35|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MRVSVTFRIVTGLVILTLSTMLIACSLNLAPNLSRLQMEDRARYCEALAVSSSLFLTQRN
SEALQDYLAAVVKHNPDISSAVLRKQDGEVFLHAGPTVNLTDADLASKFNQVRIELREQN
LPWGQLEIYYPIQHGSLQSLWYRPMTRYIVFVVGCCFLLFALFLRKTLQSLNPSRVIPGR
VQEALDTLAGGLLILDTKEQIVLANKTIARALRTTPEQLQGQPVGKLPWMIQSETEDESE
NILPWTRVLTDGETHKGITLSLESNTTVADCFVVSCAPVQDDEGRSRGVLVSFEDVTELE
KKKSELRKMLQALHESREEIQQKNQELEYLATRDPLTSCLNRRSFYEQMETLWAEAKEQG
TPLGCVLLDIDHFKSINDNHGHSTGDLVLKGIGATLMELVTAPGVLCRYGGEEFCILLPG
HDIDQTAQVAEEYRRAVERLEFEELKVTSSFGATAVSLGAENAQDLLDEADKCLYAAKRG
GRNQVSRWDLVPRDMDFSEPVAREPAPVGQTPDSQGSEAQEPAISSEAALRLGQTMDGLG
QMIDRQDFDGLADLADEVHTLAKEQNLPEVAAAAGQLRDAATTMDVVEVIYLTNQLMEQC
REYQSQHIETVAD
>A0A4P6WKG0|diguanylate cyclase|EC 2.7.7.65|Citrobacter arsenatis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSDAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NEMETLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDVTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVFQE
>A0A1A8Y2C1|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MTARKAVKQTRRRSIAAAPDAGAFAQHASDTPFSNGMTGELRLRAEALALKKAAKSKKRF
EGLTPEAIRKTLFELSVHQIELEMQNETLRQSQVLLDTARARYFDFYDLAPVGYCTVCTQ
LLITEANLFAASLLGVTRSVLVKQPFLRFIHGNDQGVFMQFCKQIAETGKSQTCTLRLMK
PDQSLFWVQLNAITLPDRDRAPEIHMVLNDIGELKRTEEALRAQEEFFHLIAENIGDFIA
VLDLDGRRIYNSPSYRQFFGSPKKLRGTDSFTVIHPDDRERVKQVFRETVQTGIGQQIVY
RLQLADGSSHTMESSGSVIRDNEGRIARVVVVSRDITERKRMEEQVRQLAFYDPLTQLPN
RRLLSDRLNQAMAASKRSACYGAVMFLDLDNFKLLNDTQGHVVGDLLLVEAAKRLKSCVR
EMDTVARFGGDEFVLMISELDADKTESTVQVGVIAEKIFSALSQPFVLNTSSEREPETTI
EHRCSASVGVALFVNQEASQDDILKWADAAMYRAKEAGRNLVRFHE
>A0A636KCG0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Uzaramo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A151AQJ2|diguanylate cyclase|EC 2.7.7.65|Clostridium colicanis DSM 13634|TrEMBL
MGKLDILLLALMLIFASIALYEYILIKDIKKSQEFMEKMKEKFCKTSEKILMTENEDEIY
SIVLDTVVDLIPNATKGSILLMDKNENFYFKAVKGFENDLIDFNLRKEEAYLYSVNKFKE
TAIIENPKKFDETNISIETIEKLKDRKALDIYCTISAPIYVDNKLIGLLNVDSSKPGYVF
TKKELNLMNLIKSELQIALKNAFAQNKLKYLANFDELTGVMNRRRFNKELSFQIEKAKQE
RRTFCLVMIDLDNFKKINDTYGHNFGDKVLRFFSHLLESSIDKSDIVARLSGDEFAILFL
NCSMDEAKKKMARINEIVSCKKVDEVAISFSYGICEVEGCNSITCTEALILADVDMYNNK
KLKKLKGSLNDKRIT
>A0A829L9G0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907889|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRVALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A0T9TB91|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MSELDSLSTLYRDACVTYATLSIGYFALSKNSPFSYSGEVWKRILFGLISGLVSLYLNRD
QWVISGSYFYSFELIPIILATFYGGWLSGLMALVINFVFSGWATLDNLLITIVFIPLLLS
KVWQKKSNRIFYTTIILIAIYRIVTALILVPNTFILTQVVIYQLIAALCLAICYHALNFK
ERHIYAYFAMKNRANIDKLTQLNNRSSVDYRLNSLHHNRQACGLMILDLDHFKSVNDTYG
HDGGDILLTEVGKLLMTAVRDEDFVGRYGGEEFIIITHSHDPQAIKAVAERIRQRVENLD
VQLPDGRKVKATISIGASLYLPGMSMLKALKMTDEALYLAKNQGRNQVVYSRLMPFSPLG
DRMVKDKRRRSL
>A0A0H5LSN0|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MNELEYLSTLYRDTCVTYATLSISYFVLSKSSAFSYRGEVWKRVVFGLVAGLVSLYLNQD
QWTISGSFFYSFEMIPIVLVTFYGGWLSGLTALIINIAFTGWLTLDNGLITIIFVSLLLS
KVWTKKNNRVFYTTIVLIAIYRMVVAVLIVPDKLLWTPIVVYQLISALCLAICYHALNFK
ERHIDAYFTMKNRANIDKLTQLNNRASVDYRLAAIHNSRKACGLMILDIDHFKSVNDSYG
HEGGDLLLMAIGQLLTASVRDEDFVGRFGGEEFIIITHSHDPDDIKGVAERIRQQVEKLS
VELSDGRTTCATISIGASLYLPGMSMLKAMKMTDDALYQAKKQGRNQVVYSRLMPFSPLG
DRMTREKRRRKSA
>A0A1T1GYQ7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4945|TrEMBL
MNQECITGLSQTWKDICDQYTENEHLAALQFIQRHVEHLVTVFYEQMSREPESAEFFKDD
IIQKRLIDTLRKWLLETFNVALNGEFESSVKRQQKVGMVHARVGIPSWFIMRGVREIERK
VFEILELNQTQNILHMCSYIVQIMGFSTEIMCRSYEINTEKNQETKHNYRLFSAMQDVAV
HKDKQRGSLLDWENELMFKIFSGNVGFYHPLFSKSEFGLWFIHKAAYAFSGSDQVQLIID
RIYEVDQLTQQTMQMTEKDQLQQLIQQIRELNREIQHLVDQLFQVAEYIESGNDSLTQLL
NRRYLSTIISREITFARQNETPLSLLAFDADYFKMINDKFGHAAGDLALKFIAEALQRYS
QGSDYAFRIGGEEFLLLLVDTGVNRAMKIAENIRQYIEKGLIRTAQGQQFSFTVSIGCVQ
YDGHPDYQRFLDAADHALYAAKNNGRNCIQVTKHLSYI
>A0A1B1NWC5|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MFARALLKNIMSARNHRFLAHSLFQYIDELLEPQSASIVSEPHSSEQPQSLYEQGDPTTL
NNYPDTFWSWVAQFDTSDGLIPLAMATCQWEGNSIINHDSYIFMIDNFSEARTYLILENV
EADKMQQASLENSLDLLQVIASRWQCVRAELEAASEYKQRDIKEAKYLDVIQQREKFIED
MKLVQRISVEISNPETIDDLHRIAVEAIREQLGFDRAAFMLLDIKKRCFSGTFGTDENGK
TVELQHTQYDLHQLEEAYINALFEGQDGLVVLEDAPLYNDGAVIGQGWNGMLILRDGDDI
IGWVALDNYINRSPITSYQKQMLESFGSLLAQIYIRKRQEQNVRMLHASMVELSRCVTVR
DVCKSAVTFGINRLGIDRLAVFLTDENCSYMQGTWGTDIQGNVVDESYYRSELVDRSIVN
NARSNPNEVVFEESVPIYHDYHIVGFGWTAMTMLTSSSGEPVAFIAADNLIRRIPLTHQQ
REMIRMFASNLTEVLSRTRAQEAVHVLNETLEQEVKERTKELQKANEQLELMAKMDPLTR
LGNRRMLESLLEDICVDDKGRGATYGLILVDIDHFGLYNNYYGHMQGDIALMRVGSILQY
HAQLSNEVFCRIGGEEFALLVVNQNEQLVVALAERIRSSIEEEAIPHADNEGRGVLTVSV
GYTVTNVAGDEFNFDALYGQADQALYQAKGSGRNIIRGYKMPLEAVE
>A0A7Y0QDV4|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNKHNFEVILNQLQINIYVTNIHTNEIVFMNKKMKEEYNILDPEGKVCWQVLYPEKNSTC
SFCKVVELLKNDKKGVLIKWYEKCNKLNCVFENYDSLITWQDGTVVHMHQSIDITNSTSL
NKQIKPNEFHKISNTEEEKGVFNVSIDNFDYNSTLLYDALIRGTDEYIYICNMKTGVFRY
SPSQVELFDLPGEIVENPLIYWEKIVHPEDWKRFYKSNTEIGKNQMDYHTVEFRAKNRSG
EYIWLRCRGQLMRDEFGKPSIFAGIMTQLGKQNKIDSLTQLLNYHEFMSVFEDKISNPMI
EKLCIVLLNIDDFKNVNEMYDRDFGDNIIKTLAQSIQSILPDNAELYKLDGDEMGIIVDN
VEEKEILTLYNQIQNMIIHLQLWRKYGLNITISAGCVIYPKHGDTVKELYKYASYSLQYA
KEHGKNRLVFFSQEILKNKMYSLEMMRDLKASINDDFRGFSLRFQPQVDTQSHKIIGVEV
LLRWTNDKYKAISPLEFIPILEEHDMINTVGAWVLRMALRTFKGLIDYYPFFKVSVNVSA
VQILEDTFIEDIVKIIDDEKFPYQNLVLELTESHTVQNMSILQFKFKALQDLGIYIAMDD
FGTGYSSLEVLKFSPIDVVKIDRVFVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVET
QEEYDLVKQMKPDYIQGYLFGKPQTATEIFDLLKLDN
>A0A1V4SIC9|diguanylate cyclase|EC 2.7.7.65|Ruminiclostridium hungatei|TrEMBL
MMSEYKGQMEVSASTGIISEGIHVAKDGTDFPFEVSSRSIDIKGELIRIHIIRHITEREQ
AEKIRYLVNYDALTGISNRGFIMRQFERTIEPARRSKLMFSAMLFDVDKFKTINDIHGHN
SGDGVLRKVAERLQAVVRKADITRKTWRR
>A0A1D8JND4|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. LTGPAF-6F|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVEERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVSAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A7C8LVX9|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MNLSKDVLFFADQVSNGVMIFSPECEILYTNPAAQKMWNHEAHSVMEGFATGIGEKTISQ
YEHPVMQAIQSNRSISQTLLRNRGAEPSVPQWVKMTANPIQDAGQLKYVLLSLEDVTQSK
HVSDLITSRSYMLDQLDVVDSITGLYNARYAPVLLERTISDVVKEKTSLSVCVFDIDHFT
RLNEAQGRGCGDEVLRYLAALLGQHMREGDVMARTGGGEFLVLLPSCSAEEALSRMESFG
TQLRSAKLACSVRPITVSGGIAEMANNEKGVQLVERADSLLYLAKLDGRDKFLTEDVV
>A0A5Y2QJ29|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAALVFSDNAAVAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARNSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLHGVHSEYEVQRICAALSLAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2K9P7C7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii complex sp. CFNIH2|TrEMBL
MENWGWLKTLARRLGPGHVVNLCFLIVMIFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKQLQFNVDKLLFLRDGMHEALVTPLGFSVLKDAVTHFEQLRHSRVWQLELDKRRTLPL
NGVSDSFVSQTQLLSRDDQSLDNELTAALEVGYLLRLAITRTSMSQQAMYVSRAGFYVST
LPTSLSSDITTRYYDYVIQPWFTGQSQRNNRMRGVRWFTSPSPDLPYEQQRVTVSVPLDN
HFYWLGVLAMTIPVSAVERFMDEAIDKDVEGEYQLYDSKLKLLAGSTPELRNANTFDERE
LAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVQGDFGSISIALALLW
ALFTAMLIISWVVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARHLTQRCRTQ
KQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEEFCVVLP
ETSLAQAEQIAERIRQRLNEKEILVAKSATLRISASLGVSSTQETGDYDFEQLQSLADRR
LYLAKQAGRNRVCVTDKG
>A0A8G0XLQ5|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MTSPVASLRLPAPARAWWALGLLVALLFAAIGWGVHAIYQAREQRYRHQIEGGLQAVNHM
QVRGVTDWRRRRLQEAAALTDDRLLAQAVARWRATAAPDAEQAVRERLRILVEHVRYTAA
YFVDPQGRLILDAGGPATGTLQPPEMRALEGALARAEPGVVELRRDPAFAFPFFGLLAPL
YDGTASLGAIWLVMDARTTLYPLLETWPTSSRTAESVLVERQDDTALFLSPLRHRSDEPL
ALRLPAEPGSRDPMVLAVAGVRGAFYGSDYRNQPVLAVASAVPDSPWLLVSKVDVADAFT
AAQRREWLALSLFVSLGLLSLGCVVVLWQGRAWRRERALKAELERNLRWLDNAQKAASVG
YFVYEGQSEAFIMSRMASAIFGLPSDGRMTLRQWVGMLHPDERAQTLEIHGRAMSERIPL
RTQYRIQRNGDGQVRWIEVWGEYGDSAGNGEPLLMTGTVQDITDRKHTEDELARYRNALE
SQVRMDPLTQVANRLALDEAVARAWSQALREGSSLSLLMIDVDHFKAYNDYYGHVAGDLC
LQRVASALASALGRPGDLLARYGGEEFAVLLPGADADAALAVAHRLQEVLRALSLEHRAN
PGGFTVTASMGLAHLRPADVVSAGTETRAGVDAAQPLFQQADAALYRAKQLGRDRVVSYD
AQCAATLYEAGQPAPAIMLTYDI
>A0A8G0USW7|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MAGVSALLMLGCIGAMHLVAAAGLTYPVPVYWWTLACGAGITTVFVLIRSGASRRFADPS
LTLFQIVYAIACNAAAYVIAGPARGIAPPILAVIMMFGVFGLTPRQMVGVALYGLVAFGA
AGAVVQWWHPAWLSPDSQPPALSAAYLVMIAVVLASSTFLTTRVHSARARLRSQQRELAA
AVEQIRELAVRDELTGLPNRRYMLEMMRLEHARAQRSRQPLLLAQLDLDHFKAVNDTHGH
AAGDVALQSFAQTVHGCVRASDLLARWGGEEFLLLMANTHPADGTRLLERVRATVAATPV
ALPGGTQLSLTVSVGLAELAPGESTAALLQRADAALYGAKRLGRNRVLLAH
>V3QWZ9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. MGH 24|TrEMBL
MQRDTFVVRQSFLQWLHNRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFNTLRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERLSHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTHDERMITA
SVPIYFDHYWYGVVAMDFTLSTMQRLLADATEDRTEGEYQLYDTRLNLIATSAHAENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADARLYQAKQCGRNRVVWQDYDRK
>A0A5P9IIC5|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MAEVQTDSVAKIRGEQIVVEDVEALRQSYQQLYIAVEQSPAATAITDVRGRIEFVNQRFL
DVTGYAREELIGQTPAMIQSGETPPEVYRDLWQTLSAGRVWQGELLNRRKSGELYWEYEV
ITPVRNDAGEVVNFVAVKEDITERKRQESELKLMATAFETGQATLITDGEMRIERANQAF
TDITGYREHEVLGKTPRIFKSGRHSREFYAELWDALLGTGHWQGEIWNRNKYGEIYPLWQ
SITAVYDDAGRIRHFVSVFHNIAERKRMEDELARQATRDHLTGVCNRRAFDAALQEAVWR
AEASGERFSLLIFDIDHFKRINDRHGHDTGDAILKQLAARVADNLRSTDLLARWGGEEFT
ILLPDTRRRGTQTFAERLRGQIAEMRLHGLRVTISMGLTEYRPGDDMDSMLARADEALYR
AKSAGRNRVVADEAAPC
>A0A1Z5I6E4|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MKNILLFLLLITLNFSALAQEVKLFKNFGIDNPMSYNFVRTIAQDKEGFIWFGSSEGLDR
FDGHKTLNFHHDSSQPNSLSSNVISRILIDNQQRFWVGTFGGGLNLYKAVSQDFLHFTTK
TKNTALSNDTVNALFEDSEGKIWVGTENGLNVISYHEKKWSTQQIFQELGNPNSLTHNAV
LAIIETDNQQVWVGTNGGGISVFDLQGNFIKSIKYGDDNSATYINKFVSSLYIDINGDVW
IGTVDSGLLKYSPSTEQFIHHQFNVDDQSTISSNAIKNIYQDSEENIWIATDNGLSIYNY
KSNDFNRYKYSPNNPYSISHDYVLTFFEDNNNMMWIGTFSGVNRWDANMAIFRQYSTQTN
PALKSSNITSFAQFEQGSLFFSTYSGEIYQLSEDDNSISPVDFNHSFSEYRIMTLFADGN
TLWVGTRGSGLYSVNLTTNNVTEYRHDTENNNSLSANSVTDIIKDRHGNIWVATFHQGLN
RLNKNGTFKRFIKNKSNSEKGPSSNNILQLLEDDQGFIWLATFGGGLSRFDPEQEKFTHL
RHEENNPNGISDDFSWIMFLDNKKDLWFGTQDAGLSILSRENRHSNNFSFTHLGAKEGMK
SMTIYGITQDAYGDIWFSTNKGISRYSMSEKTFKHFNLSHGLVDLEYTHSSVFRSMNNTL
YFGAGKGFNSIAPEKVNSHFNAPQVRLTNILKLNEPMALGTTLSDLTELTLAYTDQIISF
EYVGLNYTAPESTRYKYRLKGFDEEWIDAGKSRRATYTNLPSGSYQLQIMASNSDNIWSE
PGLSLNIVVQPAPWHTWWAYVLYAALIALLLLTYSRFLNRKLLVEQQQKEYLEQQIQEKT
QEFHLKNIELEQANQQLEDAATVDKVTGVKSRRYLDIYIEQASRLMSQIHENILPVQRSL
LPRLSLVMIKLENIKQVSNSQLVNLTDILLYSRNSDDLVIRWADDTFMIIGYEKDNNTRD
LVTRLTSRFEQVLGNNIKAGMAYAFYPFNFEQPMALSWDQVSVLTEHALKVAHNNKLSWL
GFYAPKVQPFNYLDVIQQQDIGELSKLVKLKQGDSTH
>A0A143QEB3|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MSAPEVPKVPRPPLPRSILDPASVAVVVFLVALLGIHTRPPGLLASIWFANAVALALVVR
WPRHLRASSVFALFVGCVAADLLSGTEPYAAAVLNTANAVGVVAGALTIRWRRPEPLLLT
GSPAFARLSVGIVVASVVSATVATCLSGLLVDVTPAVSPTAWFSSEFVSYLLLTTILLSV
RAGGPWRPPSPRYFDSVRWTVTVPVLVAVTLMIAGMVADGPLLVALPLPALLWCATRIPF
SGTALLTACWAGWNLLIAGRVGVLGAGEATQSPVATLSVALVALGPLLVAAVTLDRMAVQ
NKLHQALEYDSLTGTLSRAAFLRRSQRRLNTLVDASQPVALLMLDLDDFKTINDTMGHAA
GDIALVRSAGCILSALPHGAVAGRIGGEEFAVLLPMADHEDATAVADTIRRDHERLHLLS
TRTATVSIGLAWAPAAPASVSPLLDTADRALYEAKRGGRNTVVAVTLA
>A0A2N7RQY8|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MAGRLKRARWRKAHWLLALACLLPPAAYAQDDSLEQHIAAVREDGRFVPARALQRLQEVE
TQARSAPLPVRAEFLTQLSNARMRLGQHDLAMQLAEELIAYARQNDSDVALAKGILNKAY
ITFAMNDRRASHLLAFEAERIANRTDDLPVRVQATISAGQSWAEEGNFPFALAKLQAAVD
LARQSDSPSSLAAALNALTLLYTQMREYDKGFQVLDELLAVSATLASPGRMAQAKNTEYG
LALDARQPQRGQRALLAALALERQLGAKGMVATTLVNLSDSYLKEGDYARTLRYANEAIT
AARLVNNEQVEATARLNIGQAQIGQGRLQEGKQSVATGLAYYERTANQPDMQAVLLEYGM
ALEKAGDMRGAVTAYHRERGISNQLFEKQRQKAVYELQEKYEAEKKQRQIELLSRENQLK
STEIDNRRLQQRVWWLLALVLAMGTVIVGLLYRKVRHANVQLNVKNQELKRQSSRDPLTA
LYNRRHFQEFMRSHTGRGQQTQAGDVVGALFLLDVDHFKHINDRYGHAAGDLVLTNIAET
LHEVLRETDMIVRWGGEEFLAFLPAVARDGLDEIARRILNGVAAQSIDYQGQAIKVHVSV
GYAPYPLAPLGQPLSWERSVNLIDMALYLAKAHGRNRAYGLRGFHQVERTTLEAVEQDLE
RAWRDGFVDLSVVVGTEDGTGAAAAEAEAKTGRHSGADQAHGTAAAS
>A0A1V5HDU7|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA179|TrEMBL
MKTVIIVKESLDEHLSPIISSVFDSVQVIHSDEDVLSLIYMDPPDIILIDRTYLQEHDGA
VVNEFRSNTIYGHLPVVAIYTEKDIENPSALDIPLDDFIVLSDSELQIKRRIEFVARRSM
RAMDTNPLTRLPGNESIMRSIQQMFDEGKEIAIAWADLDNFKPYNDRYGFSSGDEVLLAT
ARIITNAVKEIGHGDTFVGHVGGDDFLFVCPIAHAKAICEEIVSRFDMVIRNFYNEEDLG
QGGIISKSRNGEIRKFPAMTVSIAVVLNEKKRYKHFGQASQDAAEIKKYVKGLEGSNYMI
DRRGKNR
>H6LJG5|diguanylate cyclase|EC 2.7.7.65|Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)|TrEMBL
MAEFRDKALEKEFYNAEIAKNLNYIKFTILIAGLVYFLFIIPEYFLIKDATLFISIFINR
CIIFVLLMFLYIKVSRDKTYFSLIYWFTAYEIIISLSFIYVSNQFPSPDLLIQSFGVMLM
VLTIFLINNRWLYSVFTSLFVSTGYFIFSTICFNDVPFAKFSAAIVYILIVIVLSSISSY
SINYYKRIQYQNTIELLKMVENDALTGIYNKAKFNQEYARLAEWAEQQNTCLAVVMFDID
DFKEVNDHYGHLAGDMVLTELTKIICKNIFQSDLFARWGGEEFVLIFPDVRLKQAIERVE
RLRNLIAEYTFGEIGKVTCSFGVAVFEKGDDLEKVLQRSDERLYLAKNSGKNIVK
>A0A2L0IH89|diguanylate cyclase|EC 2.7.7.65|Mixta gaviniae|TrEMBL
MQSGVPSVLNHALLRRRGSDRHPHAIVHVCFIVVLLFSSALTWREAVVLKRTYEAERQGR
VSAIANNLERQFQSSLDKMLFYRRILQYALVNPLESDNSRRAIRLFSQLRRKTSWSLNVN
TQRNMPLSGISDHELSAYGLLDRSDWARLQKEVGAALEFSFILQFTEPEKDFERRLWYLS
RAGFFVSSFPPSSNQQALDNYRIMAQRSYFTEMTPESNPLRRLRWTQVYQGGLNEGAMVT
VSVPVDGEDYWYGVLAMDFASDRVHAYLQQALPSGRQGAVLLLDRAMNTLAASDNFPYKQ
GHDLSVQERELLRQQTARADKGQLRLGARFVSWRRMNDFDGVLLSIQTWKESIQGEVGRV
SLVLLFTWLLFTLLLLVAWYTIHRLIDRLLGLQHQLYQRASHDPLTQLLNRGAFFERARP
LSALCERHQQPLALIQLDIDYFKRVNDSWGHHAGDQALRHTARIIEQQLRESDLCGRIGG
EEFCLLLPETGHEDACGVAERIRAALAAEKVAIDDRLTLQITASFGVASSSEQGTWTIES
LQSAADRRLYLAKQGGRNRVCWQG
>A0A2N7RTG8|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
METLDPRTIMLMTTLMCGAMSIVMFSVYRSFRREVHGLGHWSAGLLLLVLASFLFNMRDS
WPDAVALLGANTVLMLGIGLSMLGTEKFYGQGPSLRCYALACGLGVAGIAWWLLVTPDFS
RRVAVFSFIVFFFYARQAQLVFAHGERHFSSFFFGALMLLQACVVLLRGGMALWHGGASV
DLTVAGTQASIYLAVANFMALLLTVGFMTVATRRLQTILERRSTHDPLTQVLNRRGFGDV
YEREKANLRRKGQPLTLLSIDLDFFKSINDRYGHAMGDKVLAHVARIIGGALRDTDCVAR
FGGEEFVVLMPDMAPHNALGVAERIRTLLHEPNGHGLPPCTVSIGVACQASVLEELDQLL
SRADAALYLAKENGRDRIECDVLSVTVVRTMSAAGSDTGR
>A0A127MPL2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MAPPKQSNTIDFDTAKLQRLSQVESGRPRGRRPASLTDVRRQLAVQLQTSLEIERVLGLF
FQEIQALLPLDYLSYQNSSADLRLEFGEAASHGATYNLNHAGEYLGELAFRRRRPFDETE
LGQLESLIASLLYPLRNALLYRAAIQAALRDALTGTGNRIAMDQALGREVELARRSLQPL
SVLMLDLDHFKRINDQYGHSHGDEALRCVARAIKASLRNVDMVFRFGGEEFLVLLSNTPS
SSAAQVGERLRHAIQELDFAVDGKPVPLSVSLGCATLIAGERVDDLLHRADAALYAAKRD
GRNRLACAG
>A0A2K8UJZ7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1U1BSS7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MFTSDVDAVSNPAIRIPTPADLLHWWRMPSRYELMVSYLRTRSLIPLLRIVVGGCAGTLA
VVPLAMQFSPLGPQGPVWRTVGLVVGLIALFWMLRWWLGPLPTERTSMTFSVMSVAAICV
ACFADTDPVTGMCGMGALSLMAVYIGAFHGARLITFYLGISLAALIFQTCALGSQEGVAV
AVAKSVVTGALIIGVPPIFHLAQVALTKDAAAAMIDQLTGLHNRRGFNSQATALAAVVGA
ERADLSIIVIDIDSFKQINDRYGHAVGDQVIATSAGLIRTVTSGLATVGRIGGEEFCVAI
ASPEQPALETGERIRKELASMDTASAVTASIGVATGQLLAEESPRELLVRLIAEADHAMY
SAKRDGGNRVRGRQS
>A0A1T5HXK2|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MIKMYRFFLILLVSFFITFNFTAIKKAKLENEVEEYFRYLTDTIYTYQINVFNSKLIKGE
NSKELLIFNKQPIDNKVKDISETIDNFFYMINENSIIKGNLWSVANVYPNYMYIKPYRNE
CKSKVDERNNIGNQYFNFLLKKENIKRNLERYNLIIYRTMRVEGPFFQCKTNEKLITIYY
PLYLERKIDSILLLDIKADFLNDFFRNFNHKNMTNFKLDKTVKIDDFIYNIIVKQKYFEA
MKIPIKRSYWFFSLICLVVFTFLSVVYEFILFLRKNINENKKDKLTGFYRKDCFNDNNRI
VSCLIIIDIDYFKKINDTYGHQMGDYVLTEVSHRIMATINKSDIGIRWGGEEFVILVDDI
VNITRLHLKLNALLHAISDQKICDIDVTISIGSFLSSSNIILSEAFKYADDALYQSKKTG
RNKYTITAY
>A0A8G1FZS4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MIDNRSGKGLSFVKRIYLPRIIGLGIGLFSVMAAIAPLNPPQWAWALLLFNGLLWPHVAY
QWARRSATPYQAEQRNILLDSLMGGFWTAAMHFNPLPTVTILSMMTMNNVAAGGKRVLLR
GLLAQLGGMLLASALLGTGLQPQATQLQVLACLPMLTLYPLALGWVCYQLAIKLAEHKRR
LSALSRTDSLTGLLNHGSWKDLLLLKFQICQQQQLPAVIALIDIDHFKTINDTYGHVVGD
CVLRQLSQELRRSLREDDLAGRYGGDEFCVILPGAQEAQACQAMERLRERVGAYRNPQLP
DLRISLSIGLADFRTTLASPEHWLEQADKALYAAKHQGRDQVNFARGEAALLKLAYPD
>A0A8G1D7X6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MLLASYFASYRVQRQLLIDSALEANRAYAAKLAAVTETTLGNALQQLAYSARQSGLHPDD
DSLVQAEIDRLQQQGNLFNSTLRIDAKGTLRALSPAPLQHLAGTQASSPGALEALRTRHT
LISTPFLSAADNLLVVLSQPIFDANGNYHGYIGGSLYLRERNLLNSLLGTHFYQNGSYLY
VVDRNRRLLFHPDSKRVGTLVGDNALLDDLPNLDHGTRRLVNSQGVEMLAGFATVPSAGW
TIVAQQPLRQTVAPLRQLVLNVVAISAPLALLGCLLLYWLTQVIAHPLRQLTSVARGMGQ
QQTSERIHQVRAWYAEAAELKRALLFGVNLLQERIGRLNRDAQTDPLTGLVNRRGLQQAL
RLLQAEKRGFAVVMLDIDHFKRINDSHGHDIGDQVLQQLAGLMRGTCREGDLLCRTGGEE
FLMMLPGASLEVATAIAGHLRLSVEHAPVAPVGGVTISLGVASWSPGDGSEPSDALSNAD
RALYRAKQKGRNRVCIDSPA
>A0A8J7V519|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MALNESFKTTGNANVKLTKLASIPSIQDLDFAMSQASKHPRAIIELPWKTANATTTFVLK
VCTAAGSEDGPSWTLHAGESMDSAVLWSHDSMDTFLIQSLISAESDSSRSLQTYVDTSKQ
APVLDEPAHEPPPQSPPRSARPNLPAPLELDRAMLDAMQWHLRRQETGLLSEAYAYHLLI
QEFNRFTRYQTPFAFVLFELAMRLNDGTITLPPVRLLHESANRIQGIGRSLDNLCHFADP
RLCLVLPHTGSNETVQLCMRIEQALLQSPLAPGLDASNVLVHFGIASIPDTCEHPGILIA
AAMEA
>A0A7U8X536|diguanylate cyclase|EC 2.7.7.65|Escherichia coli FVEC1302|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKISQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8G0XRP3|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MTPHPVDTAAPSIGAPLRRWLPMLICGIGYFALAALGIWLARLPGSVATLWLPNAFCLGL
VLYRPRAEAPWLLASMVGGNLAANGLFVDGPGTAVLLAGANLFEVACSARLLRFVAAHAG
AERLAPLGNFALTLGVAGVLGPALGATAGAAGLTWLGDTRFASIWWAWWQAGALGMVVVL
PLALTITSARVRATFSRSMLMPQAGLLALCLAIGVFALWQGHDPFVAMSLPLVLAAMFAN
PFGTALLTLMATLTMELAAVAAHLQQSVPLSAALIMVFPVCIAYLAEQNRAGRANLHSSD
QRFRLAMEHSAIGMALTGLDGRWQTVNRSLSELLGYSAAELRQQRFQDITHPDDLDADLG
QMQRLLAGEIESYRLEKRFLHQDGEYRWALLAVSLVRDQQSGHPLHFIAQIEDIHTRKLA
QQQFEQLSRRTQLAVEAGGVGIWEWDFTSSGITWDARMHALHGTDAANGAPVIAQWIAML
HPEDVGRVNGEMRRAIRGDKPFDTEYRVVRPDGQVRHVRALANVTRSGDGTALALVGTNW
DITEQRRLTEALFEEKERLHITLQSIGDAVICTDAGMRVTFMNPIAEQLTGWTMASASGL
PLERVFRIVDEVTGLPIPSPVEACLQTLTPAYLQEGAVLQSLTGERHDVQDSAAPVLTAT
GTVLGAVLVFQDITTARAMQRELAHSAMHDALTGLPNRTWFEKRLREACDAARTQGHHGA
LCFIDLDRFKIVNDTAGHGAGDILLRELGYLIRNHVRPDDLLARLGGDEFGLLLKDCTVD
QAETIGHGVIDAIRSRRFPWDGRVYDVGASIGIAAIDQDVPPVGELMSRADVACYAAKAA
GRSRVSVYRRDESDARRHHRELEIAAGIHTALEGNHFRLFAQEIRALQHHCGDPRDERHV
EILVRMVDEHGEMVMPGAFIPAAERYDLMGHVDRWVIRNVLREYGERLCAVPGLSVSINL
SANSLGEPFLLPFLHAELEHSALPANRIRLEITETALINNMAAANRVVTEMRRAGCTVAL
DDFGSGLSSFAYLKQFPVDYLKIDGSFIRNLADNIVDREIVSSINDIGHRLGVKTVAEWV
EDERTLNALRAIGVDYAQGYAIGRPVPLDAYLAECEMVSTHGSSVAPGV
>A0A517WTH9|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MNSPLIANSNTVQQQNSVHGSYNMDSSQILKQLLALSEEYEEFSLEGNESDDVDQVISRK
HLRKLLTALQARDAATLCHSRRVAFLAKGIATNLGWEGIHLKRLEIAALVHDIGKIGVPD
HILFKPGKLTSDEIELMSHYHNIGLDVLQACRTDHEVLTILSQTRYHFSGATNGYQYIGS
DVHQGARILAIADAYDSLATDQVYRSGKKHDEIMSILMESAGTQFDGNIVCALSRWEQNE
KEVFHDALLEVNRLYQPKPFSEQEAQEANLISNIFSYLFQIESLYDGVYIVNSDLQFVIF
SPGLEKLADILATDVLGETWTSNSLPLTNKEGTSLTTAECSMNRVIANGKPMTTEYMLER
PGGRLINIEVQSVPMFNDEGHLVGVAEIYRDLSRGLKRPQEFSDLKLAASMDALTSVANR
GELETQLAIMLARINKEQNSPPLSIMFIDADHFKNINDTYGHSIGDDVLIELARLFQHET
YSGELVGRYGGEEFVILCPETDLEHAVKKAERLRLAISNLKIENIIKTRLSASFGVAQAE
SGDTVESLFRRADKALYNAKETGRNRVCSLTNHQLLTGEEPAQVTCESTSDEMLFENTFN
AFISSDIVVYKLGGFVNDNDAKLTEVNTSHAILRLGQTGLLPFWGKTDDRRPVEVEVEFG
NFVKKTDGNKRSSTSQVEIKVRISPLGWVKQTTQFQQRANRVFRLLKNYFAAD
>A0A8G1D3Z8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MPSPSALFSQRSLIFALLLLLAGGFLATSLLGYYASRGAIRDGIINTELPLTSDSVYSEI
QKDLIRPVLIASMMAQDTFLRDWVLAGEQDTGRITRYLGAVMGSQATCTSFFVSDRSLTY
YQAKGVLKQVRADAWRDAWYFRLRQSSKPYEINVDLDMANQDKLTVFINHRVLDYQQRFI
GAAGVGLSVESVVRLIDDYQRRYQRSVLFADARGKVLLTGSDGGPHGLRAGQQLADSSQW
QDLLARMPTPASGSHEYTDNDGHSHFLNVRLLPELEWYLLVDKRETGALDRIRQSLYLNL
AICAMITLVVLSLLNAMIKRHQDNAEALATLDSLTGLPNRRSFDLLAGQALIEAQRDSAP
LVALLIDLDHFKTLNDTHGHLAGDEVLRQFANVLQSSLRQSDILCRWGGEEFVVLLREAE
GRQAIEVAEKIRRRTEQLTFSHADQPLRLTVSIGLSALQRDDSLHNLLTRADHALYRAKQ
GGRNRVCSEMPGPDHA
>A0A8G1D2T5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MTEEAERWKEKYLKSIEQQEKLERRWEARLDLLRRGLVRSTLAAEGSDKTVDQCMKEMRE
VIRSDNMDAGLAGLIPRLEKAVLDSEQRRETRMNQVSEALTALVTQLQTLPLPGEVSRPL
KKLAKKLDGGVSQSRELPPLLGELSGLQGRALSAVQKPEEEARPGFLQRLFGGRDEAPGE
MVPAPVAVEVPVPAAQESPVIAPEAQARDADELHALAPVPPVAPEPAQEHTAPAELPEPE
PEPETELPGPALVETTPVPVVEPKAEPQAEVEPVDVAVAEPVALVEDVQPVPDELEPATD
EVIGEDGPYALPDAVEPPYSQVAAHIEQTLIGLLDDLSLPERHKAQALEMRERVSRGLNW
YELIPVLDDLAVLMLAITDSGQHEFEAYLQQLNERLETFQSHLHEASAGHADNSSAAREL
DSQLREQVDGLQSSVQGAVDVDSLKHILENRLEGLLVTMDDHQHERDRREHELASRLQGL
AERVASMEQEALGYREHLEEQRQKAMIDPLTGLPNRAAWSEQVEREVLDWQENGGHLAMA
ILDLDHFKRINDGYGHLAGDKVLKIVADQLRKRLRGRDFIARFGGEEFVLLLPQTSPPAA
AQVAETLRAAIEACPFHFKGERVVITTSIGISAFRSGERGDQVLKRADEALYRAKELGRN
RVEQG
>A0A2U3QE57|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MLFKRYPVLLTHSATSRLVAAVVVFIVFGSGIIWTAIAYYEKRHLMEQAVEYTSSSSNLI
RKSVSYQMLTRNPQAIQSTIENLVDGDNIKIIRIFDGKGRVAYSSRPKESEAGPDANTRT
CSGCHDDHGVSAGTLSEKRDWRIQEEGKSRNLIFSEPIYNEPSCSSADCHFHPRSQPVLG
RVETVFSFVRIHKQMDKTILNKTLFPVVSLWVASFAGGFLFWRFFYRRSSIYSKDLTKNV
AGGPDRVFSTAGHLEKLGITSHVFSGRTSETPGTASARDILKGEVKDRPADAEDVVSVAI
DSIRDPFIILDREYRIVKANEAYAEMRGIQLMDLMDAKCHEVIYGNHERCKNCVVEKTFR
SGDPCAKDKLLNVKDDRELWIEIYTYPIHDEYRKVSHVIEYFRDITDRKRTEKKMKVAYM
EMERIFDNAADAMCVIDEKFKILRVNNMFLNLIGRTKDDAVGRRCCDVFPGPECGTPNCY
LSRMLRQPDRVIHFESERSLGGGKEAHFIITATAFHGDDGKLIGIVEDFKDISEMKKTED
ELRCLSLHDELTGLNNRRGFLALADQELKRADRLQQSIFLFYFDLDGLKGINDSLGHEEG
DRALKAVTSALKATFRNSDIIGRIGGDEFVVMPTGGGNVMGVSTRLQANIDMCNKKNDRY
KISLSKGVASYDPACPCSINELLIKADTLMYEEKRRKRS
>A0A2U3QK67|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MYQLLDEQSLRKAFDCLSVLTGLHYSLYDDRLNEVISPVQEDPLLSFLKSQKKGQELYNS
LMEEPFRLSLKRNNPFIIQCYTMQHLVVVPINYKDLRLVATAGAFYSSAEDFKRFYQQNV
LKFDLERKGMEGWLKEITVIPPEQIAGRLQSIHSLIESLVSSGYEKAELSRKWRCSKTII
SLMANMNSDAQIRDIYQTIVDAVVFLFNVDTAAVFAMRGESFIPEVAIGRMKAVIQKTEL
SKDNKFVLQAHVSGRPAAVIDGHELWYNGFPEEVVSMYLFPLSSAFGSFGFLGVFNSLLD
REVFNAVQELCMLASYLCGIRQQKEECEIKSVTLTQVSDRIFSLCSYFREPERLYQGIVS
EASSLVGAEKCSLMMPENGEHMLRVFASKGMNKWLMGDVRVRLGEGIAGRVYEKGEKIVT
DRAEVILEYAAAVKPHYRTLSSVSLPLRVADETIGVLNLSDKFSDEPFSEKDIDALASFA
SQASVLLRLCDYHEKSEQMRELSITDPLTGLYNRRYFNIRLDEEFQRAKRYDLQMSLVMM
DIDNFKLFNDTEGHLAGDYILREVASIMSAAVRANDILVRFGGEEFLILMPQTSKAEALW
VAERIRKNIREQIQPSWKRYPARQITISAGISMYPDCDGQKDLLIRCADKALYEAKIKGK
DCVFVWEGGG
>A0A3N6EWI7|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI96-15|TrEMBL
MDTHLLAAALPALGWAAHTSLLTHRLTTARRDPLTGLHTRDGFTTRADRITRRHPDAAVL
LVDLDDFKAVNDTHGHAAGDAVITATAHRLTRWTGTHGITARLGGDEFATALTSLTPTTG
LAALREALHRPVAHHGRWIDTSASLGICHLTDLPAPTLTDALAAADAAMYADKGHGRRNN
HH
>A0A380STJ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MTDEAQRWKEKYLKSIEQQEKLERRWEARLDLLRRGLVRSTLAAEGSDRAVDQCMKEMRE
VIRTDNMDAALAGLIPRLEKAVLDSEQRRETRIAQVTTALASLVSQLQTLPLPSDVSRPL
KKFAKQVEARASQSREMPLLLGELSGLQGQALLALERPEEAHRPGLLQRLFGNREAEAEA
EALQPALAGTAVAVPEAREQLAPMPQAVVETAPQEPVDIDELQPLSAAQALVPEAFEPAT
VEAEANEEPPLTAAPEPEPEPEPEPVLELPTEPEPELPAPVESIILDSEQDVLALLEHSP
DDPPAHQPEAEAVDDEDAQYALPDGTEPTYSSVATHIEETLLGLLDDLTLPERHKAQAQS
MRERLEHGLNWYELLPVLDDLAVLMLAINDSGQHEFEAYLQQLNERLESFQSHLHEASEG
HADNTSAARDLDSQLREQVDGLQSSVQGAADLGSLKNILENRLEGLLGTMDEHQQQRDQR
EQEMASRLHGLAERVASMEQEALGYREHLEEQRQKALIDPLTGLPNRAAWSERVDQEVLE
WQESGGHLLMAILDLDHFKRINDSYGHLAGDKVLKIVASVLRKRLRSRDFIARFGGEEFV
LLIPQTSLPAGCQLAETLRAAIEACPFHFKGERVTITLSIGISAFRSGERSEVVLKRADE
ALYRAKHLGRNRVEQG
>A0A1C5USK3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIAGTFLTVFITICRDLIQGTAKHYKLPLIGLVAAMIAVMLEVTAVYRVVSLSGIFIATG
LVVLLVVTLIQTMDRIRELELARQREARESLDYLTGLPMRHKGEALILEKMQKQGGCLGF
VDMDNLKKINDVYGHKAGDRALRLVGEVLTECMKNAVVCRLGGDEFLFYLPEVSEAEMNT
RMRSLFDSFRAAKNAAAETSAASLSCGLCMCRQGDNFEEYYIKADKALYYVKQSGKNNYR
FYEELEEQ
>A0A1C5UJN6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MPDLYFFSLTVINCFVLGFMCMIVNFSETLFPRQRRIFLLTFILIGVISVLELVTVIVDG
TPVRLRPVNIMANYFGFGLTPAVPFLMVYAMDRSDEVRLGLKATAALEILYLLILTAGTF
SGGLVFAVDAENHYARAQGFWLYMLMYGGGIQYLMFNMLKMTQTYQNRGRVLIYGLAVFL
VAGTMIQIVLPTLHITWLCVTLISVLYYLYCNEMWNQLDGLTGLLSQKSYLNRTLNLRPE
DKMLIVLDLDNFKYINDTYGHQAGDQCLKVIAECLKKAYSRYGNCYRIGGDEFCVLFREP
KKEKYCREKFYWIIEKRKKSLHMLPCASYGSALIEEQESISDTKARADANMYANKKARKQ
AR
>A0A1C5WG49|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKIAVLIGGLRFDSQRRIMNGILEKAVFDGTDVFIFTCDSWTYSSPYYTKGETAIFSLPD
LKDYDGVILHGDTVYDKSVISELVKKIREARIPCISLNVKYPGMLYMGMDNANGIYGIVE
HLLQVHRAKHFAFISGPEENMDSTERWESFRKALADNKIPFDNRYFYYGDYHPESGKKAV
GYFYDLPGAFPDAIVAANDEMALGAFYKLKELGYEVPEQVLLTGYDNAIVGRNHSPRITS
VERPETELGAKAYEKLRDVILGKEGSEETTLKSHLIFTESCGCHDSEAEPEESFRMKMIT
DKLHVTEFSEIVKSSSADFTGAPTFEQLLAEIRRYIKLINPNEFYMCMCVVEDSYQTDRN
YEITGKTQIEALSQYAPEICIPLIYRRGEFENYGRFPVEKFLPDKYTVAGKGRFYTVVPL
HYQDRCYGYCVIGNSRLMMDSELFHLFIMNINNALENLRKQSMLNSMVHRLNRMWIYDTL
TEVFNRAGFFKFAPNLIHEAIDRKENLFILFLDLDGLKSVNDRYGHDEGDAFIKAMGMIL
RQLHGNGELVMRYGGDEFVVMSKNYTDEKAAGYIRRIERSIDEYNMTSGKEYKLGASMGY
SLVEPEEDMKLEDLIEVADQEMYKVKKAKKERLKNQQP
>A0A1C6CUU7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MADSIDRAIVEGRVYPSASDILPGGTATAALPNWSLLRLSPGLLALTGWESAEALIQASG
GALYDLFCPEDRPCILAALESLLASAGRIKAEYRLLRRSLPPLWVTLCAGLVDTEALGIH
LECFLLDLSDLRRAEAELSERCQTLAEQARRETMTGLLNKDAFRLDVRTYLSAAGPEETY
ALLVTDLDDFKRFNDRYGHTFGDQVLLAFAAILSRSFGPGALCGRYGGDEFVVFLPGTAP
RTAEEALHGLYRNLKCRRKGDPMFQCSVGAACGKGPAEYSRLFDRADAALYRAKRAGKNR
FQMDRGGL
>A0A1C5NGC6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLADDYIILIPVLSALAYFYFNWRYFVFLQRQKEMPHIRKGFVLICYMINYLFFVFCSAM
EYVLIVNWSVFAMILFFETEWYTHKDRRCSLFGTLTGIIIGLAINILFRSVISIIMNQPL
RDFDNHIYHEGNLKGIPIIVGFVFAGIVFQVLSMPVFIKRLKLILRYPQHHSFMLELMTG
LFFYLFLNLILYSAPSNDWVLKGFSIKSCLFSMVGYCVAVWYTWRICLLSDYQEKSWDVK
QKLEAWEEIEPQLRHQAFHDPLTGLYNRQQADETISSMMDQGLGFVLCFADLDGLKRMND
TYSHEEGDRYIRAVTQQLRHACRKEQDLLFRYGGDEFMVLYTGISAEEAADRMEGVNIRL
GEMAAKGEFGCPVSISYGVEDSRQFAAAEEMVAAADRKMYRQKRLKQGRSGEQIR
>A0A735NNU7|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A (strain ATCC 9150 / SARB42)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A446C311|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MRIHLRGLVLALTIFSALVATANTLYASYRVQREQLISNTLESNRVYAAKLAESAGAFLK
SALRQLEYSARHLSVRLDVPELLAAEASRLQEQSDSFNTVAIVRADGILLAASNSLRGFV
GTRVDSAGSLAALQARKPLVSKLYVSLTGKQLINVSHPIRSDDGRYLGYVAGTIYLSQEG
ALHTLLGKHHYQDGSYLYVVDNEGRLIYHEDTARVGESITANPAVAAVVRGQAGAQRLVN
TRGVDMLAGYAGVPLSGWGVIAQRPAQATLEPLDKLIWALIGYAAPFAIAFLLAIWWCAR
KISQPLSQLATNVEHEEVAIAMQRVQSVKAWYFEAQRLKRAVIRSFTSLQDEIGKLNQAS
ITDPLTGLHNRRGLQAAVERLQAARAPFGVIALDIDHFKRVNDTYGHTVGDEVIRGLAQL
MRECSRPSDVLCRNGGEEFLILLPGAGAKEAANVAERLRKSMETRSLHGTSGITLSAGVA
QWPSAGAEVGAAFQAADAALYAAKQQGRNRVVTHAP
>A0A2S8DCH1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFWIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A3R0JNY5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELAMLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2X2IAA8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKLRHPGGNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKHESFLICSCTDI
TEERRAQERLRILANTDSITGLPNRNAMQELIDHAINHADNNKVGVVYLDLDNFKKVNDA
YGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASQILTRLRL
PFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRV
FEYLWLDTNLRKALENDQLVIHYQPKIT
>A0A3R0JKI1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGRQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A3R0JTJ9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A0S4HZC2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MNQTRTLGTPRLLGIVWPFIAVVLFQALLGGVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LNLYADNRDEAIFRKYQNAIAVPQGGHELRVALDLQPPDIEAARVAILKGGNHPDDVSSL
IWLYLNFRHFTYLEKAIDRWTVGDAYLLQLNDVAQEMHQRITEGQATTADIWRWKDRIFA
INDAVTPAAKAFSDALGEGSRLILRLLLVTNLATALGLIALALLRTHKLLRQRHEFAEAL
QLEKDRAQITLQSIGDGVITTDVEGAIAYMNPAAEALTHWKAEQATGLPLAALFNLLDEN
AQADGFTLIEHILSGQLSGGSEHSKLIQRLDGSTVSVTLVGSPIRNAGKVSGTVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEFRLEQALHNLTRHSGRHALMFLDLDQFKLVN
DTCGHAAGDELLRHICALLQSGLREGDTLARLGGDEFGILLENCAPEAADKIAENLRQTV
QNLHFVWKGRPFVTTVSIGLVHLAQTPTSLEASLRAADMACYMAKEKGRNRVQVYHADDS
ELSLRFGEMAWVQRLHMALEEDRFCLYSQEIAPLGHTERGGGHIEILLRLHDEAGRMILP
DSFIPAAERYGLMTALDRWVVENVFKVIAQCISEARKGPLAMCAINLSGTTIGDEAFLDF
LREQFVNYSIPPEMICFEITETSAISNLGSAIRFINELKGLGCHFSLDDFCAGMSSFAYL
KHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVESPQIEQALLEIG
VDFAQGYVIERPHLFTCDSLQSRPARPQPLLFKAPGTFR
>L1M2G7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida CSV86|TrEMBL
MVAQFPDALTHALKGLVETHKATLAARFYEQMLADPNASLILSHEDVKSRLGSSMQAWLV
KVYSARAGDDFLPLVALQKQVGEVHARIDVPLHLVLGGARYLKKQLYQLIAEQGWAAQEH
AQILRLASETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNITTERERQRGALLDWE
NSLMFDLAMGASGANLPRLAAADFGLWFRHKGAYAFQNTRESEQILAIIRHVDDELLPRF
LAAAGDEAARMSLLREIRDRTKSLMFNLDSLFNSANELESGRDVLTRMLNRKFLPVVIGN
EIAIAQKTGQRFSVLSVDIDHFKSINDRFGHDAGDLVLQQAAEILSSHSRAGDYVFRMGG
EEFLMILVDINNANALKVAEKLRHKIGAETFNLTEGRKHRLTVSIGVATYSGHPDYQHLL
RQADQAMYQAKQGGRDRVVSYDTLDG
>A0A5E7EXW2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKMGGKGFSLARRLYTSRTLGLALGLLCVSVAMYPLNPAPWVWGLMLFNGLLWPHLAFQ
WARRAKRPYHAEHRNLLIDAFLGGFWVVAMQFNPLPSATTISMMAMNNVAIGGMRFLLAG
TAAQILGVGVGWLIFRPFFIPETSQIQLYACLPLMCFYPLALGWICYRQAYTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQQQGGAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNSAAAAMEALRDRFATLGYEQNPA
LKVSLSIGLAAFNPRHTDATLWLNDADQALYGAKSTGRNRVICSDERPRQELLGSV
>A0A5E7D2F3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDVDGNAGPMKRLRQHSRPTLHSVIGRGHWIVALVAVAMASLSLTLLSVLALRVHADHNL
HLIARSISYTVEAAVMSDDKVAATEALALIASTEEVAQAEVFDARGRLLTHWQRPESGLL
FDLETQIARAFLEKPITQPILHQGREIGSILLTGHGASLLRFLLSGLAGILLCTALSAWV
ALYLARRQLREIIIPLHRLASVAHTAHIERAFDLRVPPTEIAELDNLGNDFNALLDEMET
WQTHLQNESQSLAHQASHDSLTGLPNRAFFEGRLIRALRNAKRLDERVAVLFLDSDQFKG
INDHFGHAAGDAVLVAVATRVKAQLREEDLVSRLGGDAFAILLTSLHKNEDAERIAEKII
ASMDLPVQLWGSTSVLTSLSIGIAIYPDHGASPGALLNAADAAMYQAKCLSRGQHTAGAD
LPAANVQTRG
>A0A5E7QG20|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSLFKPGSRPTLRSVIGRGHLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKAAATEALALIASTEEVADARVLDEKGRLLARWQRPESGLLSDLELQIAK
AFLEKPIDMPIVHQGREIGSIQLTGHGGSLMRFLLSGLMGIILCTAISAWVALYLARRQL
RGITGPLRSLAAVAHAARSDRAFDRRVPPADIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLMRALRNAHKLNERVAVLFLDSDRFKEINDSFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKTEDAERIADKILASMEEPIPL
PGHTQVLTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRLSRGAQHTSGAEHPVAHVHT
RS
>A0A0B7D152|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MWIGDLSPIGGDTTANLTARLHWSSASSLPPSRTPLPLGTSPKIPYLKDFAIPAGLGVAV
VVNAARPLRIVPMVNNNQKDSSLPQWPEAAQTLMALMHAQGEVARLSEREQLFSSLLVSV
NAVLWAFNWENRQVLYVSPAYERIFGRSAGLLLADYNQWRDSIYPDDLDYAERSLAEVLH
KGAVEDREYRIIAADGQVRWLSDKCFINRQDEPGQPVIIVGIAEDITDKKQMETELQRLA
TTDVLTQSSNRRHFFECANREFEEARLQGSPLAFLLLDIDDFKIINDTYGHPQGDSVLQA
IAECGRASLRRGDLFGRIGGEEFAAVFPGCAPDMALQVAERLQQEIQRLSFSQDGQTFGI
TVSQGLTSLTESDESLDSLFARADAAMYEAKRQGKNRIISA
>A0A1T2ZDU2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAIFKIRSRLRTLLSPAVTKIELAGLVAWIVVLLIDPKTTLNLPNTAVTITLLSVWQIH
RKTASFMGWRVLGGVYVLLLSLGFGNVVASHVELRIFTLSLAVIIVVSSAILFITVQDYL
LSAALVWAVLWPSLDLGLYSGLEVYLGIFIIASISIGTILSFTYLRNMRSILVKESEFRT
LAETDFLTGILNRRAFMDTFQRVLAEGHNGYFIMLDIDNFKQKNDQYGHDIGDKILCAMA
ACLKLTPGSHNVGRIGGEEFGVLLLGDNDVVAHEYVIHLLANIRGSVLHPHQYTCSAGIA
QFSAASDMSAVLKCADSNMYKAKHDGKDRVFQNGRRVGQTLLGTT
>A0A379J7A2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNGLGREQDQDFFIEAQVRTDCLHQLFRQSFSAVFGSYLAAGMLCWLCWDRLDRDLMIGW
LILLSGSSLLRLLMFFQYFRSPRSERTPRRWELHYWLTLVLSAGIWGAGALAIMPTDDRL
TQALVILFTVGMSVSAVSCYSAYRYMTMVSMALVLLPCTLWLLFQPSKMQMGMAIAVLVF
SSFVVGASRKLSEALEKAFRLTREIERAHSISTRAAETDELTGLMNRRAFFEKAQVLYDQ
CKRTRQPLCALMLDMDHFKAINDTYGHQTGDRVLQQIGQVISASFRQTDIYGRLGGEEFA
VLLPDTTLEVARDIGEQLIRAIADLTIDPVQVLSASLGVASTLAVGDDLQHLMNTADKAL
YRAKALGRNQVVVAS
>A0A1H8VAM4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. NFIX58|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPLNGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSLVN
HFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVADRIRCRITSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADVRLYQAKQSGRNRVVWRDQDRK
>A0A087DMJ8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium stercoris JCM 15918|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIERLQPDLIVLDVML
PDIDGFTVTRRIRQEGITTPVLYLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTQQQVEDDPIIRVGDLEINEDSHDVSRAGRPIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIVIEDENGDKHKVTPLIETKRGIGYMIRA
PKN
>A0A1C6J310|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MEKSVKDNPEYKMKRQGMIIGLVCLAVMVFLTIFLMSRYRQRTEKIFTELMEESLLSTHS
EALTEMENFLAGSAGADKVEEAWEALNEDEGNVLHYACNSDGKILAGDMRIFDIEYTVAT
VLHSQHVKDNSISQVEKSLKKLTYGAPHIFTELEKTDIYLVASKLEGRDCILFSEYRSAK
MKNYKAVLINGNRMIIFTLLGCALIMLLFTVRFYMKQQKKVMKGQARYDILSEFSDTVLF
EYDCLEKTLVFTPNITTLFGLKEIGPIRPFDNDTDFTMVHPDDVAKVKALLSTIGNNSDE
IDDFVIRFKDKNDNYRWVRWMGRLIRGRLGTPQAFLGKISDVQDEMTREQDLREKASVDG
LTGALNRKAAEQKINTLMQDKECKGYLLMLDIDDFKTVNDTMGHAIGDLALITLVKLLKE
HFRREDIIGRLGGDEFIVFMTNTELASAVEAKGAEILDILAKSETTPHFTVSIGAAAYPA
AGNDYESLYLAADNAMYASKKSGKNRIYVDNGQQKKE
>A0A1C5YCR0|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKKKKLVFLAFATIAIALLLEAGILKYVNDSNTYRMSKVLLDRVITVLNKNDDSENGLIE
SLKDDYIVRAKAVSYIIDAKPQVEYDVEELQKIADLILVDEIHLFDKNGYIYSGTLPKYY
GFSFDSGEQMEYFKPMLTDKKLTMCQDVTPNTAEGKELMYAITWNEAGTRMIQIGIEPKR
LLKELKQNEISAVVSDMPVYKGIEIFVADSQTKIVKGATDSRQIGVKLEGLVVSSDKKSG
ETDVRLIRIGGKRCKCLLSQYDDYIVAVTIDSSFYRQGNIFAVLIVGVYLVLASCCMFYL
LSRVMKEKYEKEKLLYISNTDELTRCFNRHAYEERINNLDLREEWIYISMDLNNLKHTND
SLGHAAGDELICAAANCMRESFGKYGNVYRIGGDEFVVIITGNTKEFQSIIESFDRRVAQ
WHGNLVDSMTISWGYVFSSEKEWDNIYDIAKEADERMYKNKERYYQERNIVRRR
>A0A7Z7YIX5|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDSNIESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHARAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A5X5PTS8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Offa|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8H9NRT7|diguanylate cyclase|EC 2.7.7.65|Citrobacter farmeri|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSVGASLVLFPPGALNFTYTAINIIEAAAGAMLLRKLLPWYNPLQN
LNDWMRLAFGSAVIPPLLGGILVWILSPQETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTLTVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMASDPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRALTFQQLTWPEDLNNDL
EQLTLLVSGDINSYSMEKRYYTREGEVVWALLAVSLVRHPDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPSWSVWYDCVI
PEDREYAEKVVRDSLAARLPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDMKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTELRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVSSSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLGMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIINAVNDYHFMWEGRLHRIGASAGITLIDENNCQVVEVMSQADIACYASKNGGRGQV
TVYEPQQELAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARSFWLISLRLWTSE
GEVMEEQAFRDSLADPALNHALDRRVLHEFFHHAAPAVASKGLSVALPLSAAGLASATLI
DEILNQLEQSPLPGRLLHLIVPAQALLLHPQESTAALQKLRQAGCHIIVSQIGRDLQIFN
LMTKNMADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGIKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A1V5CPA1|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin058|TrEMBL
MDDAKRLFIIDDDEVTLNVLKDYFERCGMAVFAFKDAPPDLEKELKEKDPRAVLLDIVLP
CTSGVEILQKIKDIRPKMPVIMMTGYTNDERRIESLRKGAYTILTKPFDSFEEVYHVVNN
AMEHCIESLRTMELARRVEEKQRLEKINILEIDFLKSLQHMIGEAEEPGFVLKNAYALLK
NFLDFEYFGVLLTYGNEVNIQIYPKAGSNRRIAEVITNILLKRMSQGAVNAKTTDAGDDY
QSIIAELSTTNTVYGFAGLFRGSSFQSQEETTFGKFCSHISVTLEKIRLFQEIKTLSIHD
GLTGIFNHTYIITKLNEEIERAKRYHSDLSAMLFDLDNFKDVNDTYGHLAGDYVLQKIAE
LFTKKLRTIDIVGRYGGEEFLVVLPETDLERAYVVGERLRTGVEQEQFTYEDHHIKLTVS
GGIALYRQGHIANDLIKIADNNLYKAKREGKNRLYYD
>A0A4R8SPJ6|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MAAFSGAGGVARTLPLGDMSRWWSSPSRYDLMMSYFSTRSMRLALRGAVGGSAGALAIIP
LAMEFSPMGPRTGVWRSLDIVSSLLAFFWMLRWWFGPLPKESESAIFSVSAVASVCIACF
ADSDRGTGMHGLIALSLMAIYICSFHGARLIALYLFVSLATLAFLAVAIDLQHGWAVAVA
DSVVTATLLVGVPPFIHFAQLALTSDARAAAIDPLTGLHNRRGFDDQSATLAHAARTDRS
ELSIIMIDIDRFKQINDRFGHGVGDQVIADVGSHIKAISGNDAVVGRVGGEEFCVALRGP
ASQAREVAEQIRAGLESLDAMVTVTVSVGLATSPPPTSSTAPDNLIGQLVADADHAMYSA
KRQGGNRLEAWDLSG
>A0A4R8S957|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MAAFSGAGGVARALPLGDMSRWWSSPSRYDLMMSYFSTRSMRLALRGAVGGSAGALAIIP
LAMEFSPMGPRTGVWRSLDIVSSLLAFFWMLRWWFGPLPKESESAVFSVSAVASVCIACF
ADSDRGTGMHGLIALSLMAIYICSFHGARLIALYLFVSLATLAFLAVAIDLQHGWAVAVA
DSVVTATLLVGVPPFIHFAQLALTSDARAAAIDPLTGLHNRRGFDDQSTILAHAARTDRS
ELSIIMIDIDRFKQINDRFGHGVGDQVIADVGSQIKAISGDEAVVGRVGGEEFCVALRGP
ASQAREVAEQIRAGLESLDAMVTVTVSVGIATCLPTTSNSPPDKVIGQLAADADHAMYSA
KRQGGNRLEAWDLSG
>A0A1S1V7F6|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MKNKIVSLIIASLVSVLLILGFSLIYKEQIDSVSKQNRLLAVQELTVYSDRVQSIINTSL
QYAEFIDLLVTTNPDIPEETFEKYSNLILKDHTIIKNIAIAPNAIVKHIYPLSGSEAALN
HDLLSDSERRPFVKAAIESKESVTQGPVKAKQGGYLVFNRKAIFLNENSKFWGLSVITID
FDEIIKKIGLAPEKNGYLLALKARKTDGKNDFIWGNPEVFDKDYLGKNISLPNQTWELAI
YPVEGWAYRENHSNGIVYFFYVIVAIAFCFVYLTVEHYQSKITLSRKDPLTGTLNKMSFQ
DFAKKQLLKSKKRHAICVIDLNGFKEVNDTFGHPVGDAVLIEIADRIKTTLRSTDRVSRF
GGDEYILFLNDLREEKSLKLVLDRVNSITEEPVVVGDIEIETKFALGYAVTPDDAATYEK
LYAIADKRMYKHKESLKNSKENSQD
>D6CQ96|diguanylate cyclase|EC 2.7.7.65|Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)|TrEMBL
MPTISDQARATLKRLLELKLQPTPDNYRRVFESLQKGAALPSAEPSLESPDWGRALPRLL
EQWERSQSGLTQLQKRQQLDRLAALPTPQAQWRELEQLLERWSALPARSGSQSASTPIET
RDDALSRAGSEWRELWLQTLKFGVRPFCAHDTAQRLLRELMAAAENAEQAADLGTQAREV
WLAIDREQSTEEAVRNGLIELARLLLDHLGDLVPQAWVGVQATAIREQLQTPLVPERIES
AQNAVRDLLVRHSVLRKSEDDAHHTAKALIDLLVRKLGDYAAEGGEYNQRMEARLQQLQS
SREWDEIRDLVQDVLDDSRNMQQRSGELGVHLAEAQRQAQAAQERIRSLEGELEQVSQQL
QEDPLTGALNRRGLDAEFTRMQSRVVRQGQPLTLALLDLDHFKAVNDTHGHDTGDAVLKA
LVAQAKRLIRPSDRVARMGGEEFMLLLPDTPVQQSLVVVQRLLVAFSDQTLVQDSTGRRI
PLSFSAGVAELCPDEDFAAIYQRVDAALLQAKQAGRKRVEFAVPCDGAKAGGSLPKSALR
FFALRG
>A0A7G2JQA6|diguanylate cyclase|EC 2.7.7.65|Serratia grimesii|TrEMBL
MDISAPNHLTSRKSVLFTHTLLAAVTVFLLALLCLTLSNEPSHFTPLWFPTAAIIIVLYR
HSPRQWALPLLASGLGIISASVILYGFSWLPVKLSLINLLEASVSTLMLRRMLLPDDPLN
NLASWLKFVVCAVIFTPLFSALLAAWWAPAPEQSFWQPFNTWFISEAIGVLSLAPIGLVY
RRRMLEQLNLFSLLLTLMMALIFCYLALTYLPFPFTFVILPLLWAAIALPRLEAFITCFC
TTLMITVMISLGLLHFNVPAEPLSDIEIYLPILLILIPAHSMAMVMHAFRVEKQHIVESE
ARFRNALEYSAIGMALVSPQGKWLQVNQALCKLLGYTPEALRRLTFQEITHPDDLNADLE
QLRDLLDGHISSYTLEKRYIRSDGEHVWALLAVSMVRDAEGLPLYFISQVEDISELKRTA
AENHRLVERITLANQVGGIGVWEWMMDGEELTWDKRMFELYDLSPDQTPTLSLWRTLLLP
EDLERTDREMSSLLDQPRPFILEFRLLTRQGKIRHIRGQGNVILDSQGRPLRMIGTNIDM
TEVRNLTEALHQEKERLHITLDAIGEGVISTDDTMHITFMNPVAEQMCGWPLSLAVGMPL
AGVVRMTNGKDGMEVENPVQCCLQENRQLSADYALVLHSRDGRHFDIQQSVSPLKTIGGN
VMGAVMVLQDVTASRELMRKLSYSAAHDALTSLPNRTSFEKRLKAAIVGAGEKQRQHALV
FLDLDRFKAVNDSAGHAAGDALLRDIAQLMQRHVRDSDCLARLGGDEFGLILFDCASEQA
KSLMQQLVNHISQHPFYWEGKVYHVGASAGITRIDTGSGKSGELLAQADIACYTAKHRGR
GQVYLYEARQKQMLERQHELLTRQEVMSIIADGQLMLSVKAVAPPRTPLAVCFYQLKLQI
MPLDPRPLNSDAFIAAAQLYGLLPDVDDWISRQILERHAAEISAKGLTIALPLATDSLLD
TGFRHHLITRLNASPLQPQALLLVVDEAAVLEHDDICRPFIHQLQQLGCKLIVSGFGHSL
NAFDELHGRRIDYIRIDERFITHVHCNQMDELMVSMLNGAAHRVHAQTLAGPAHQQITLN
TLQALGVDLADGDAVAREQPLTELLSGGYFGIR
>A0A395LCZ6|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MGGAISLLAVNFVIAQIFTAAFLVIAAKSRSRRAALYCAGGFAVASLAAVFETVVPFTST
PRLFAISAFASVLAGFCLLRFGLGIFYRVPANWQMLAAFFLASVALDLVIYHWPRGTLQH
AALYQLPFFIIQAWSASVIVRSKRRSAADRILLSLLALTCGYYVLKVFVAVAAGSGATAQ
DYISSPFALISQALGAVLIVGTGLAMLGVMVMEIVDDARARSEIDLLSGLFNRRGFTERV
APMLQRREGRLPGTLILADLDRFKLVNDSYGHHTGDEVIRQFARVLKDVMPNHAIAGRLG
GEEFAVFLPSTELEEARVVAHGMRAAMMSQQIDGLAEQARVTASFGVAAIAKDEPLELAM
QRADKALYAAKENGRNRVECAAAPQTVVNPQVPQWIGRP
>A0A395LD43|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MQIFENTIQQSVFFRSSIRPLWIGGLCLTVFAACLLGIFSRPFGMLASVWPANAILLGLF
VRHPSLSTPAAWVCAALAYVLADLLTGSSLGAAVALNGANLIGVGVGYALFMRLSTEHRH
LRRPLAVLYMFSISAFAGGSASIAGSLAVAHYFGEPITRAFVAWLTTELVNYVVILPVFL
AMPAFAERERVVSVATTASAASVNPWPIVSLVVSCVAALLIGGPGAIAFPVPSLLWCALT
YRLFAVAVLMAIVCMLAQVAVASGILHLGVDRLAEATLISTRLGITLLALGPLTVASIDA
ARRTLIARLSHAVDYDFLTQCLARAAFMVRASALIEADNRKTPIFALMLDIDRFKVINDT
HGHAAGDRVLQAVAVTIRMTLRPDDLLGRLGGEEFAILLVRQTPANAARVAERVLAAIRA
LDVALDNGEKLSVTASIGIAELLPASAGLEGLLSQADKALYAAKAEGRDRIHVFADGTPE
VGAMVGRHGAARQI
>A0A4R3VL08|diguanylate cyclase|EC 2.7.7.65|Samsonia erythrinae|TrEMBL
MNGLLSVNEQRDYDEPDYNQAITSEWKQLIATTSPQSFELLQTLAVQKASDFADEFYSYM
LKDQDASLFLSSQQVHDRLQCSMTKWIIDILTNTGERLTELMGYQKKIGHIHARIGIPAD
LIERGTRRLKLHLYESITQATDDKTLCFDALRFSSLSMDIAIEIMNRTYSQSHNLVAKHE
ESYRLFSILENASIERERQNASLLHWENSFIFSVATGNPISNIQELSDSEFGLWFNHKGK
SSFNNVQEIRVIADMITETDEYIRSYSNTTPLVPQDYAPLLKAVRSKLYKISMLLGSLFD
QVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHANSSLSIAMIDIDHFKAINDTYGHTT
GDNILKKIAEILYENTRNSDYIFRYGGEEFMIVLIEMSKHAAYAIIERLRKRIQDHKIQL
QNGEVITITISAGIAVYRGHPDYECLIKAADDALYQAKSNGRNRIEYAPE
>A0A4Q3ZTI5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKDVISTPRPTFKRTLRRISMISVVITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVS
RWLFPLPVAQPIMHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILIASAVALTITRSL
HHGMVAEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDDSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTEREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENGSVEALLEQADRNMYLVKNQRSKTIS
>I6EAW9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGISPV
>A0A240ENQ4|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MVIGLNKEDRGVKRYSVLVLILGLVLTIFITHLVYKGQKQLSDSNFEFLVHNQAENIKEL
VMLDVAFIGAGASFYHATQPPTWDNFSTFVAPLLADSKSLIAMQWMKKVYPEQIASHVER
VKQHFPNYQIYTVPKDLPRQDGYILENDEPIYVASDVYPVNEANLRALGYYSSRERVRRV
IRNTLKTGEPSLSDKIRLLQDGFDRSLPKQGMLVYHPVFEIGENSLRGVVIGVVRTTAYF
EQIVSRTSIGKEVGIQVVDLGFDAEDDPIMYENQGWKTLSGATKSVIIDLYDRQWNIQFK
HDSDISHNDRVILICVASGGFIISILLAYVVQLMLREQRRLTKLVSRRTRDLQYLVERDP
LTEVYNRRAFNRLADYHISCHKPFSLVIIDIDKFKQINDQYGHVSGDEILMQVAACIKTE
LYPDDMLFRLGGDEFAVISRCVDEGLLKGYLSNLCAEISMIKWDSIDPNFFCTLSIGATV
FKGESLEKLMNRADDLLYKSKDKGRNRAMVA
>A0A8B2XI98|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. AM17-18|TrEMBL
MDKDFTSAPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINVHKKRFAYWSWNPKDNNDTLGTLVS
RWLFPVPIAQPIMHNGSMIGEIRLTARDSLISHFIWMSFAVLTGCILFATVVAIAITHSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSARINSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLEKADRNMYQVKNQRTKTIS
>A0A7Z0VNW7|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MNEKDWKERYEDLLRQHESEDEANRELKELLTRTIIRLTLAANGLDSRLDPHLKGVRDAV
RGGVNDKLKSKLNALSDGLLHFSEDAGEEDVDTTGDYIKLLNSLQLNKKEAQEAAGLMHQ
LADDPSQMEIGQFSRLVQLLSREQPVKVKKTGLFERLLGGPQGEHEQGPKPNDILLNLLE
QASWPGHWGDEINQLKRRLDGKASTDAWSEVLRDLLELSAKSYGQVQMEIKEAEDFLEEL
TQRLQDLGVHLQSAHDGRNQIIEHGRSLSEKVTGHVGDLGESVQAATDLQQLKTAVRDRL
SLIQSNIDDYLQEEKQWHRKTEASEQELKHRLAKLEKESSELRSRMVEAHHMALIDAVTG
LPNRLAYEERVEQEYARWKRFNDPLCMLVWDIDDFKSINDRFGHQAGDKALRVIAKSLQS
RLRVTDFIARYGGEEFVCLLCGTKGGEALKVADEMRRSVETNGFHSAGKPVPVTISCGIA
PFTGSDSIDSVFLRADKALYEAKKAGKNRCQLG
>A0A8H9CC54|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADSAIAAMSRVHERLVNMPLH
GAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGRGRTEVAA
>A0A7W4I3C2|diguanylate cyclase|EC 2.7.7.65|Gluconacetobacter diazotrophicus|TrEMBL
MMSVAQVAVDAELRRAFTNVPDATRLLVHDVVERLTPALVAAFYDHFTSHPEGQTYLTDP
ETTERLRGTLMVWMAELFSAAPQHPQRMADSQRHIGRFHARSSIPIHLVSEGVSLVQRTI
IHALGHENLTHEELTDAVLYVTNVLTAATGVMTFTYWRQRERAASNDVAYRLFALNQDLS
REGEGQKAALLGWSYNVLRSLYVAKTPEDLQTMGLARSEFGLWVTYKVGLLFEGTDISAL
LTGQIAKVDNELLPAILEDMAAERDISPALAALHAGVTEILSSLEVLFHASRSSNDVEDP
LTRVLNRRFLPSIISYELRVAHQTGRPMSVLFLDIDHFKHINDTFGHAAGDSVLQAIARV
LEEASRLSDVIFRYGGEEFLVLMGDTDTEQMLIGAERLRQKIENTPIRLPDGNLHQITVS
IGAAQYAGHPDYEELLRAADAALYRAKRNGRNRIEVADAPHHTPAPSLEGAS
>I6E495|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLG
>A0A652ZV54|diguanylate cyclase|EC 2.7.7.65|uncultured Spirochaetes bacterium|TrEMBL
MKCTAILIIFATLLAPSSFAQNGGRQKATAQESLSLIPLQTMAELYANADPALTVEKLAG
HEGDPLFSPVGGKMIAVGAKNPVIWLRFTIPEALRSAGAGTGEKSGAAWSGLPPQWLLVV
RPSFSIILDQVELYVPSVEGGFESFATGALRKAFPGEAFSRYFVFQLSPTAFGGEYCYLR
LSSTTEVKVDVFLETSLARDSQEKIDFFLYGVLFGFLAAMFLYSLALFFSLKDKSYLFYS
LYTLSAGLWLFFLHGFSKALFGQSPGTDQAMLWVWVGLMLAWGSVFVAHFLRLKDGLAAL
NRLVLALGALGIVVSVAGLLGWYDIAFSLSHYLGIILPILGIATALIRLIQGFPSSLYFF
VAWIFLGIGGLAFALMGLKALPVNFWTINSSAIGVALQSVFLLVALSDRFRRLEGETERL
EKIQANYEALNLTDENTGLPNKRFLMAELGTLVEKAKQRKTMLSLLLIDVDNFGCLSDFL
GSAKPEDVLAGLASIAKASTREGDRVCSLGGDRLAVILPGIGAQAALKAAERIRVRFAQE
GYRGDDSGGHTGESLMVSLSIGVVELGKDDDLDSLLDRSDRAVHEAKVQGKNRSVYLRSV
E
>A0A652ZSQ7|diguanylate cyclase|EC 2.7.7.65|uncultured Spirochaetes bacterium|TrEMBL
MVSAEEPGHSRLDAQFPFSSLHPDDLTRAKDSINKLIAGTKNEYNDQLRFILPDGATAWL
ALSFQLLKGDSDGGYSFLIIRETNVTDLVAARDEIKERLLEIESLKSLLTAINKSLDFND
TISTIIDHLHHIIPFDKASVQLLEGGCLRVIGGYGYTEEQLKDLCFPMGSLDSPSARAVA
SRRPIVCNDVEKDFEGFIKVDEDIEIRSWLGIPLVFEDKSIGLLALDSIKKGFYTHQHVR
LASSVAEHLALAIINARKHTLIKAEARTDKLTGLANRYGLETIGQELFSKAASGDKPLGL
LMLDIDHFKIFNDNYGHGYGDQVLRHIASEILRSLRGDDYPVRYGGEEFLILLPDTSTRE
ALVVAERLREGIAHLTMGGGREFPTVSIGIFSGVPSYTELLHEFIRRADLALYEAKGAGR
NRCRVWTPSPEYYSK
>A0A652ZV87|diguanylate cyclase|EC 2.7.7.65|uncultured Spirochaetes bacterium|TrEMBL
MSNYLQSLGKAGSARRRKITFYVLLLVFVFAALEIFILAYRPPKDALLVEPEVSFLRDEV
MLGQQSLPLLLSSGGDPNFISGEYSFTLRLLLPEGTEGSTRKVLVFPQISGSSLEVFFDG
EKLGSRGDPVSGQSSIWNSIHQFCLPTQLTAGEHFLEARIQGTYEAGIVAIPYVVNADTN
SLRLFMLDFFTNYSIWLSIGCILIVSLIVLSMGFFTEQSRSANLLLGLAGLAVSVFLTDF
VYIERLPMSLVAFKKLVVSLRHFSVACFTVAYLRLLGKGLSLAAKAFAAFQLACFVLIIV
YPGDIIAIKRLYSLTFLGFIPSLLYLLYKVIHHAAETGDLSILLFGVLVVFLSAGRDIVV
MVILRPDGFILISHYGFIVLALSSCAFVVNDSLRQYKNLAFERSRAAAFREEALRDELTG
CYNRKLLPFLTGNLAKPYSLLVFDIDDFKRINDRFGHETGDAVLKELVCMAGRNIRSHDY
IVRTGGDEFLIILRSCPLQIACFLAEHLIAEANSFAIPLPGGQGGEVGPDVGARTYRSAG
ADAYRATDTDPMLRFTISMGIASCAEDLRSTQDEFASTLRSADAEMYRAKNQGKNRWCAA
GLQDRPALVQNDA
>A0A377M9S7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MALLTVLFIGSLAFAINIKAFTLHSLPAFIVCLWLSPSEHWLRMIYSFILPVVAIGVHHV
LQRRNDRFAQELLSRLLEERETLTDLSMMDPLTGLYNRRGLQSRLENLPAVENGEHFVLL
MDIDHFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHAR
QTAERIRQKVYDLKIPTCSMSASRLTSPSALVLPFSRMKTQKARWKKQIKPSTKQSILAK
>A0A377M0Q4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MRSDPAAFTLFRLESPLRNAAGIFILTTLFYFIGAELRLVEALSLFWPLNGVMAGVFARY
TYLNRLHNYAVSYVAMLMYDAVTTNWGMASVVINLSNMVFIVVVALLVVRDKRLMKKTPD
PINALRLFNYCLFAALLCALLGATGSVGIDSHTFWPLFADWFSEQFSTGVLILPCMLTVS
MPTRAFKLRLEQLLPVIALIVSVMASVVIGGAGSLAFPLPALIWCAVRYSLPATCLLTFL
TGGLEIVLVANSIINIAVGTPLSTPMMFSARLGIATMAICPVMVSVSMAAINSLIRQVSL
RADYDFLTHVYSRSGLYEALKREEAQRQTRFLTVMLLDIDYFKSINDNYGHECGDRVLAG
FAREVQQVVGDDGMVARMGGEEFAVVVNTGDAQHGFALAERIRLTIAAHPFTWRQQTLYL
TVSIGLGSGKAASWQLTEVFNRLMAEADDHLYRSKKAGRNRTSARVSDDPITRPRRVKPE
RSLHSAGDES
>A0A6S5JZM5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVKQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALLTPLGFDVLHDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISDEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A330EMI2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPLNGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTEDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSLVN
HFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQALPFSVIQIDLDHFKSINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVADRIRCRITSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADVRLYQAKQSGRNRVVWRDQDRK
>A0A1V4VR49|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin117|TrEMBL
MVSRLTTRQLLIKKVEEMIYNREGPFSIVVADIDNLENINNTYSPKIGDEIIDKLVSIFM
NNLSENDLSTRQGDEFMILLVGKGAERSLMEMEEIRRYLSDNTFGFSDGEIQDDIYVTIS
CGIASWPRDAKNAIELLRVADSALFRAKKLGKNKVCLSEVESMVLKSSYFTKTQIDRLSE
LAKEMEKTEAFLLREALDDLFKKYSK
>A0A381F2Z0|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MENGMPPDASPWHRWGRTLAGQLAAAAGCGGGGLLLGLCLPAEQAGLQQLGLPFALALLL
RGGARLWPGLVVGMGWLAWREPGPGWAGILLLSASGASAALLGASAARTRRRPFQNLAGA
LVFLGGPALLASALAALGRLFAMLPAHGQASAQWLAELCRAWLGNLAAVLALTPLLLLAG
MPTGRRLRPQTVFAAAATLGLALLLGVVADGRGGDRALLPFLLILPLLWLAFHGRLLLAH
ALSLAIVASALAGVRLGQGALATGDAGHGLLNVAVLCIVQSATLLAFGALLAERRGVERD
LLLAKRGREAKAAERTRQLAESEARLRLMADAAPFPLAMNRLAGGELIYANARAEELFGA
RLRPDRPLRVQDFYADPAEREKVARALLEERAVRDREVRLRDAGGRPFWALVSCELVQSG
ETWYVINGVNDISERKRLEQSLQDANAALRSHLREIELLQQGLREQALRDPLTGLFNRRH
LDDILPRVLAHMLALHREVAVLMVDADHFKRINDTYGHRCGDAVLTALGACLSDHFRSGD
IVCRYGGEEFFVLLPGATLEAAYAKAEGLRRAVGERPMEALGHSLAVTLSIGLALCPLHG
SDAESVVRAADEALYQAKRQGRDRVCVAARLQSLLS
>A0A377GNP3|diguanylate cyclase|EC 2.7.7.65|Fluoribacter gormanii|TrEMBL
MDEKTNLSPSFDTYSDSRLSKYVLYVISVPAFVIVLIISIYSYKQVRDLVEVNNWVAHSY
QVTQATDKILYTVVDIESHQRGYLVTNDNLFLEYIKTATKGLTERFDNLLQLTKDNPPQH
ERVIHFIDLVNQRLKIIHQVIQFKKDNNINSQDTQALVHKGQEISDVVRSLGNEINAVEM
VLLNERNLVVINSAHKTNLIIIIGSIVSLSGLIAAFLLGNYELASSLKAERRRISTEIQL
KSILESASDMIAAVNSERRFIIFNESYHREIRRIFSKSITIGITLEEAFADVTDSNRALI
TLWEESLKGEEFVKNIELEINKERNIYEITSSLIINQNNEVKGAVHIVRNITKWIEEQNK
LKDLNSNLNSGLQALKDKNRQITLLVEMSDILLACGSLEELNNVVTKYCQRALNFANGYL
YVLHPSKNYFESVASWGDPTPQEASFTPEHCWAIRLGHIHTVSPSHHDLICNHIKIDDDQ
KLLSHCVPLMAQNDIYGLLFLEMKEEDTTLYSDDHLLLIKAFSELIALAYANVRLRENLR
YQSIRDPLTGLYNRRYLEDFLFKQIHQAERAKLPLSILMLDLDHFKRINDTYGHDAGDVV
LIEVGKVLQEDIRVEDMASRYGGEEFVIVFFNADPKSIKPRADNIRHAISMLKIKYGVQH
VGPITISIGISSYPEHGRTLVELIEAADKALYFAKNNGRNQVVLYSDIQNNTESSSIKDD
NAE
>A0A6N2XZ31|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MIKDDFLTLTAQKFINTYFTSRNFDQVKNMFAPEGSWLGASNNTMANNLKQFDQYFKEGC
NEGYVPEITFQDCYVIYNDDNIGIVYCNYHLHIESKGALFDMDQRVTIVLKQFNTTLKII
HVHASTPNDAISQEEFYTNEIAKLGYKELQQALKKKNEQIEMIIRTTAGGMKGSLDDEFY
TYFYVNEELCKMLGYTYDEFMEMSHGTAVGAVYPPDLPAALADCKRCFAIGPEYKTEYRI
RKKDGSLLWVMDSGRKVTDENGQVVINSIITDISELKEMVNRLKIDQERYEIVSQLSDDI
IFEYDVENNSLVYQQLQADTPVKNILTNFLTVDLKNTHLYHGDIERFKKDLKIILSNQVS
NELYKLEYRFAIAPQSYTWYRLTFRRIFDNDNKLTKVVGKVVDISSELRLKHQSITDPLT
GTYNRLYITSAIQEYCHILKNNLSYACILIDIDYFKKINDTYGHIIGDRFLIEIVKIIKR
FFRASDLIGRIGGDEFLIFIKDIYDKEIVREKADALIKKIHEYVTANNYPKEISISMGIH
IDNRPEISFTELYNKVDIALYNAKHNGRDRYVYYHEGMTYPK
>A0A517P0A4|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium K23_9|TrEMBL
MTDTTGPATANASSNASPLNATKVASASLQVAAEASQDDVSRLLGKLQETAPRAKESRQP
TSTSEIENQLAVVRLGMATSLYYSLRTKHAPTAAHCLRVSLTCSAWASRMGLESEGRDRI
EVAALLHDLGKIGVPDRILRKPSKLDVNEQLAMDCCPQIGCEILRGCTSDQELLNIVRHA
NTWYQSRRREEFPQGDALPLGARMLSIAGAFDAMTTEHVYRAAMSREQAINCLIEGSGSQ
FDPELVADFARMLEAQPEMLHGAVVDRWLRRLQTNQASSKWSDSVDRTSSKPNKISVRRE
THFHDRLLRDLKDGVVFTDSEGIITHWNATMVKMTGIATDAIIGKSWNAKTLRLQSPASD
ANETTCPLRECYDRSAPVTRAMMLDGTGDEPTSVQVQVSPVSGSKPGILGSVIIIHDNSF
RADLEEQLVTLHHKTTMDALTGVSNRAHFDETLDAMVQSTSKGESRFSLVICDIDHFKRV
NDVHGHPAGDEALINFAHVLRQHSREGDLVARYGGEEFLLLAANCDNATAAKRADAIRQA
LETTVMPSLGGECVTASFGVTEYQPGDTAETVLARSDRALLKAKDNGRNRVVQLGSGGGT
VDMKAPVPAKSGWFSWFDSSSKSTDAEVDILTPVPADLAIEKLKGFIADHSAEIISVDES
QVSLKIHALSMGGRRRIDQHIGLRLDLTLSEARQDELGTARKSALGHSKIHVILTPLRNR
DRRSSELQDCVDNVIASLRSYLMGEIMAKPVGE
>A0A0X1U7E7|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MDHLSKFLRGLGHWKESLLAEKVDLYKEEICNRNYNNFLGLTTVGIIITCGILLVGLPLS
EYFTFNNQIFVLLGFCVILYLIAKFYLHKKKKYITLIFYCALSPVMFMGILMGTFLDSQV
PSITIMVFLCVLTLFMIDKPWRIFFYITCSAMIYAILCYYAKPKSLFLSDMMHLVAFYCL
ALGINFLTLNERIENVESFVKYKSKSEIDLMTGVYNREVGLLKIKQLIYNQIKGSFIILD
IDDFKKINDHFGHMYGDSVIKEISHLIKGYFSEEDIVLRMGGDEFIVYSINLIEMNECRR
GLENLLDSLRSSAIGWEKGISVSFSIGCAINDKEEVDFNRLYRESDQCLYVAKNSGKGCC
VIKK
>A0A377IV41|diguanylate cyclase|EC 2.7.7.65|Fluoribacter gormanii|TrEMBL
MTGALSRVTMLSTLREQQEIIKRQGQSCCLVMVDLDYFKEINDRHGHQMGDRVLATAVRL
FIENLRAYDKVFRYGGEEFLLCLPFTDLDMGFAMSERLRKVLEAITIDDGKEHLIQVTAS
FGLALLEPNKPIEESIEHADKALYLAKSEGRNRVRVWK
>A0A6N2Y627|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MKTVKDAEIFCQYIAHEYLGKRNYKLLKDIIDKRITIIGTGAHEVSRNIQELMTALNKEA
ELWDGTFIIEDEWYQGTELADNLFVVIGQIEGRQNSNDQLVYSFSSRVTFIIEYHDMQWK
IIHVHQSVPDYSQGDDEFFPQRIVEESNAQLKKEIAEKTKELEMSNQQVIYNLRHDYLTG
ILNRPSLEKEVTEAMSNHQYGVILVLDIDYFKEVNDNNGHPYGDEVLIKLANTMQESFKS
GICGRIGGDEFIIYLALDDANYDAIEKTIKEFKQNWQKNITTIDRSSTITLSIGGAYYPK
HGKNYQELWSNADKALYLSKNNGRNRISIYQL
>D2TII3|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium (strain ICC168)|TrEMBL
MEMYLKRMKDEWVTLVEQTDPQIRRLASEIATRHAHDLSIEFYRIVLADPHAEEFLSNEQ
VERQLKHALEKWIVDVLSSGVEDVERLIKVQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PIIIDGHHDANDKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEMDIIYKIMLDADFGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGLFLQSRETAKALSNKAARVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQADTLRIAERIRLRVEKTKIKSPDGATIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRQGRNRVELWSPAS
>A0A1Y0N9Y6|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MEPSQETTGFLARWRASQEANHQVQGEATMESLRRFRGVACFTAPLHAILALVFASYSPP
AAHPELAQWARALVDAQLAAFVGVVITGLMTHALLRRRQRANAAAIALQIAISGLYLYFG
AHVTLIDLVFNAGAGLASYLMICIMFGVLSLMRPAISVPVFGMTYLVFVSMLEHASVNPL
QLTSLHVIAAVAPALALVTAWMNWSQYAKSVLLRRQLKRSNEALVVQQQELAFLADHDAL
TGLYNRREFIRLAQMELLRATRVPCETAVIMVDLDFFKKINDRYGHPGGDAVLKATAACL
NQALRATDTLARLGGEEFIVLLPATGREGALQVATKLRDAVRNAAIAFDGGLIAVTASFG
VSSVPAQKHGTVDAIYAAADRALYVAKQLGRDRVEYAAPEASELRP
>A0A5K1I8A3|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MRTLLRCLPGTLFLALLMAIFATSPARADTAPVSLDEGWEYRWGDSPFRADGTPAWVDDP
ASQGEWRPIAFPSNPPGREGSKHAWFRITLPEGEWRDPVLYIYSVDLILQAWLEEKLIYQ
YGEFDDRGEGRFSGWPWHMISLPENFAGKTLHFRVFSDYTDIGLWGEVKLMDRLDLMEYI
LERSAGDLIIGALLLLMALLAFIFALVQGNRRSFIGIGLFAMAAGIMLLAETQASQLLLD
NPLLWDYLAAIGYYTLPVAMGLMLEHWFAAQRSTLLRRIWQLHLGYLVMAPGLALAGVID
LSSTFPPFDALLLVTLLAMFTTIIVHLGTLNIEQKLIITSYGLFVFLLVIDMAVAHGLLS
WRRVPLSGGALAFVFAMVMISLWHYRHTHRELQRLNLSLEKQVTERTRELEQMVETLQAY
SYQDALTGLHNRRYFDELLEHQAAIARRQGTPLTLAMIDIDHFKRFNDREGHEAGDTVLV
GVGRVLRHHFRDADVVCRMGGEEFVVIMPGATSASAEARLAQLLEVLSRTHFRHRDRVLG
PLTVSCGIATYPEHAGDPLTLIGLADKALYSAKHRGRARIETYA
>A0A8F2ZXB3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans str. Sal610|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0U5N5H3|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MSDLGERITRELTTRYVAVLVVLGALALMSFVALTRMIVDAEGSAELVNLAGRQRMLVQR
VAFAANRLVIVDDAERAATARLLGETLDQIEERHDRLMRGDKSPPPASVMEVFSGPPWNL
DRDLQGFIARGRAILAEEGRPSATNPDLAAISAGAVGSLLRSLDELTIRFQRDSESQMEE
LMKLQAVTVAVAVGLLVLSALGVFRPMVERLQADIAERSANAARLKESEERLWRILEESP
VGVSVSRRRDGRVVFANSRFTDIIGMSKEEFLGSKARDHYVDDAQRQVVLALLRRDGHLD
DVEVEFRRKNGAPFWSLLTIRSLGFADEPVNLAWIYDITERKAAEQQIMLASKVLETVTE
AVVITDADNRIIFVNPAFTTITEYSKDEVRGQNPSFLRSGRHEPEFYAELWRRLSETGHW
EGEIWNRRKSGAFYAEWLSINALRDVGGAITHFVAVFSDITHRKEDEERIWRQANYDALT
GLPNRSLFLDRLNQTVRQSKREKKRFALLFLDLDGFKAVNDTLGHAAGDVLLQQTASRMS
ECVRAADTLARLAGDEFVLILDGVHGRDDPALVAGKILRLLAEPYALEAGTAHVRGSIGV
ALYPDDAEDGASLIRRADAAMYAVKRMGKNNFLFSADLPSGD
>A0A8I2CUJ0|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium|TrEMBL
MRAILIVQESADPRISELVGSLFDSFKVITGKQDVIPMIYMEPPDIILVEGRFLVTRGSG
IVQEFRSNTIFGNVPIVAILERRDIEASSWQDVAIDDYLTLDETDSAITRRLEFISRRAV
RDMDMNPLTRLPGNESTIRTIQALFDAREEAAIAWVDIDNFKPFNDRYGFSRGDEVLAAT
GRIVTNAVRELREEKTFVGHIGGDDFVFICPAGHVRGLCEEVISRFDMVIRNFYNDDDLE
RGVIASTKRDGSEKTFPVMTVTIAVVLNEGGRYTHYGQASQDATEIKKYLKARDGSTYMI
DRRALKT
>A0A2N7RG97|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MTHNAIQRLLLKRFALAAATYGLALLLLWLAFFFGHYPHSLNSVAIGSALVLITQATLFA
LFWSGRNLRFADPSLTEAQVLLGLGWQTWLIAHLHEARGAFLVFYVLILLFGLFHLSRRA
FIRCALLVFFSFCAITLWDGYHFRLTDPALAALQVCILAIVLAWLVIYARFVQVSRQRMR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLASRELDEMDPGVVHGLALI
DLDHFKRINDLHGHAAGDQVLQAFAGVAGACLRDGDVLARYGGEEFVVLLPDCDAERLTA
CCERLRIAFTDVELVGLNVRDLSLSAGMTLLELGDHLDDALQRADQALYRAKRDGRNRCA
AAWENVDA
>G5QE88|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rubislaw str. A4-653|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A370V1C2|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MFKYKKKAAGICFLYFLCVSVVTCYLYTMYVKDRVNSVKVSIIDSGLAIANVSEYRRSVS
NNVFYELEISPDELLNKIRDSFSNFQHPGYLYDLGPYMISDDKCIKITSKGDDFCDDIVS
SVRVINEFERGVISLKDKYYVYYAHPIAKRTSLISVVDPERYLSLIRNQSGEREDIYVSF
YDINDNEKKIAGDDFLINDAVFEISAITLTYSYIPEMIFIVAYKKSKYIYMCLLFVFASA
VSAVIIYYYYINLLQNIIYKGRLEKESILSDHHYGLRGENLFFNTEEINAIREIYDFGTY
DALTRASGRRSFDKDIKILSEKFGYLCLFDIDKFKTINDKFGHLFGDEVLIKIVNLIKDE
LPRSKGEIYRFGGDEFAIIYHDKDVSQLTRILHRIVHFSMGGLNCSCSIGVANTDESINN
IERLKLLADERLYKSKQNGRAQITWC
>A0A370V3S3|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MYVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAICYVAMLAYDAMTTEWGLVSLVINLSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPVIALIVSVIASVAIGGAGSLAFPLPALIWCAVRYTPQATCLLTF
ITGAVEIVLVANSVIDIAVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVS
LRADFDFLTQVYSRSGLYEALKSPSLQQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLIAEKIRKAVELQPFTWQQKTLYL
TVSIGVGCGCASYSTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A645E8X7|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MYTRRKVGGLKANFCLVYLDVDHFKRINDTYGHVMGDAVIRYLGGQLLAYTRSSDYAFRY
GGDEYALILQDTDLSSGKIIGERLRRLIEQNPLVIESTTIPLTISLGIVEFQDEKANSEL
ICKADKELYKAKSEGRNRLCG
>A0A644YJW1|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MIMMADMNGLKWINDNLGHKAGDQALAIVAHLLAKHFDRCHCYRIGGDEFCVLSEQYTEQ
EFTAVAETFTQAVSAQKIAAGHALSISCGYVRQNGRTVDQTLVKADSEMYEKKMAYRSQN
GIG
>A0A645IZX5|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MEHSIRSTDFLSKWGGDEFVLLMPNTELSSAISLIERLRLKIAELSFEGIRITCSFGIAE
LAEEDDETIILDKADKNLYLAKAEGKNKIRF
>A0A645EEN7|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MMFDLDRFKLINDNFGHDIGDVVLRRTVEAINEIIKDTDIIIRWGGDEFIGVFYGLKKEE
AIEIAQTILDKINSIEIPVKTSEIDDIVKIEMSIGVTYFSKSDRQASDAVKRADDAMYES
KETGRNKVSYFDVEDLNE
>A0A8E0FLD7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 97.0246|TrEMBL
MKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKHLQ
YNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPVNGVSDA
LVSEGNLMSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFT
RNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYG
VLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHTTGNIFDPRELAMLAQ
AMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTM
LLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSV
IQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTE
AAEDAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQ
AGRNRVFASDNA
>A0A2H6GLZ4|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin14|TrEMBL
MKITPGGVLATDGRRFTQILFPEMIRLLSAVPDKTRKIRFHLTSLKPLNPKNAPDPWERS
ALLRVEKGEPRVYGFSKAPGNRELFRYLRPIYAEKMCLDCHAIQGYHLGDVRGGASVTLD
VTDLIWAFSVNTKKEIAIGIFLWIVGLALIFLVFTSVERRKKYLVDLKAMSLEDYLTGLS
NRRGFLVLAQQATRLIDRVNFKALILLYFDLDDFKQINDVYGHKEGDAALTLFSQVLRST
FRQSDLLARMGGDEFLVFALDTGESCEKMITDRLQRNLEEANAESGKPYFLKVSFGAVEY
DPDRSAFFEELIIEADRRMYENKAAKKASGGGADDDGQH
>A0A192CAW2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNSETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A5I2XI47|diguanylate cyclase|EC 2.7.7.65|Salmonella potsdam|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5J0NSJ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Telelkebir|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7Z8BBV8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A174GSN2|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLE
ITGNQNDELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKEILKSLSREKER
LNSCENQLPIDYACGWALSSDDMACTMQMLLDDADAYMYKNKQLCKKYN
>A0A2A7MMX5|diguanylate cyclase|EC 2.7.7.65|Clostridium neonatale|TrEMBL
MQDYKKLYDSLKCEYEAYQRFSEKHIQELCEVNVKLENSNNSLFNIVEISKYINTFFSDD
NLISMINDMIIGILGVANSTIFLMENDELIIKATNIEDSKINLTSEEIKYVYSEQEFLIN
SKDPIKQVGSNCSDIHSVMGVPIFLRDKFMGYIIVEHKVYNFMTVELKLFLKSIANQIAI
SIENSFLYKQLERLSQTDPLMNIYNRKYFFDYMEKVIQQENYDKCAIVMIDIDNFKVIND
NFGHQFGDKVLINTGKIIKSWLGDNDLMARYGGEEIILYITDFDDELSVYNKMNIVRRAI
EGSVVSFQGKEKSVTASFGIAYFPMNSRDINELIKIADDLLYKSKNLGKNRVISAHDEKF
KTLLC
>A0A2X2VNV0|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MIAHELNALDLLSFPVWIVLPHTEELVFANTAARELTQEQTFSRLRKGIFSTYAQNELRM
YVADLHHHHDIVEILTVCRDGKEIALTCRLSVKTLSTQGDVIIFEGIETPTAQGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGLIVDANLAALNFYGYSHEAMCQKHTWEIN
VLGRQILPVMHEIARLPGGHKPLNFVHKLSDGTTRHVQTYAGPLEIYGDKLMLCIIHDIT
EQKRLEQELERAALHDALTGLLNRRQFYLLTEQNHTPHLSMTMDYSLLLIDTDRFKSIND
LYGHLKGDEVLCALARTLEARARKGDLVFRWGGEEFVLLLPRTSLEVALNLAESIRAAVA
KVCIPGLPRFTVSIGVARHESNESIDELFKRVDDALYKAKNDGRNRVLAA
>A0A291JMW1|diguanylate cyclase|EC 2.7.7.65|Staphylococcus nepalensis|TrEMBL
MFEAIIYNIAVTVAGIYLFHRLQYSENKNMVFSKEYVTILMTIVALLLTIKPIPIFHEYV
LYLSFVPILFLGRYTNMVYTVLAAFIVSLVNVLIGDYTIISAMILIVIAIIVGAVGPFLK
QNDIISLQILNLITLVIFIILSFISPYYEFKEVLYLIPLSFILTITSSITFVDIWHFFSL
VNRYENEDRFDYLTGLGNVKEFDRHLNETTRIAEKNGESLGLLLIDIDGFKDVNDTYSHD
SGDAVLRQIAQLLKNYVPQQFSIYRNGGEEFSVVLYDYTLDQCVKLSESIRKGVEQSTFH
LPNKEVIKLSVSIGVGYLTKDDYKSQRTVFKVADDMLHMAKNEGRNQVMFNPIVKL
>A0A6B0TBE2|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MSKQTQHVLVTLPHPLLRLVSLGLLTFIFTLFSLELSRFDTPLAPLWFPTSIMMVGFYRH
AGRMWPGIALVCSLGSISASLVFSPAGSLNFGWTAINIIEAVVGAILLRKLLPWYNPLQN
LNDWLRLATGSAVIPPLLGGALLWLLMPEGTPVKTFLIWILSESIGALALVPLGLLFKPR
YLLRHRDPRLLLETLLTLTITLGLSWLSMLYVPWPFTCIIVLLMWSAIRLPRMEAFLIFL
ATVMMTSLMLASDPALLSTPKTYAMMNVPWLPLLMILLPVNIMTMVMYAFRAEQKNITES
ELRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRALTFQQLTWPEDLHNDL
EQLNMLVRGDINSYSMEKRYYTRDGDVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
ERVNKRLMERITLANEAGGIGIWEWELRPDVISWDKRMFELYEVPPHIKPTWQLWHDCLL
PEDRAPTEKIIRESLAARLPFKLEFRIGVKDGIRHIRALANRVLDKDGDVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVVCIDVDMNVTFMNPVAEKMSGWQQEHAIGIPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGRYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFEGHLKEILLTVRDTRQHHALVFID
LDRFKAVNDSAGHAAGDALLRELAALMLSMLRSSDMLARLGGDEFGLLLPDCNIDSARFI
STRIVNAINEYRFTWEDREHPIGASAGITLINNANRLAADVMSQADIACYASKNNGRGRV
TVYEAQQEQAHSEREVTSQDEQWRIIKDNPLLMIARGVASPRIPETCGFWLISLRLWASD
GEIMEEQAFRAGLTDPELSHALDRRVFQTFFQHAASTVASKGVSIALPLSAAGLSRATFI
DELLEQLERSPLPPRLLHLVIPAHVLMQESDKAIPAIQTLRQAGCRIVLSQVNRDLALFD
CLSAHMADYLLLDSELCASLHGNLMDEMLVSIIQSHAQRLGVRTIAGPVQMPLIMDALSG
IGIDLIYGDVIADAQPLDLLLNTSYFAIN
>A0A5Y2YK34|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLSAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G5RIC5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGQAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGEATVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGC
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A288Q9I2|diguanylate cyclase|EC 2.7.7.65|Weissella soli|TrEMBL
MLKTNLTTKKYRNKLLMYSYVQGIGLIMLASILIYMQYFHGIWTNISYVLSVSIIIFLFL
GVKRFFSLFNKYENQNALYQDSFEILVNVSVYIVDLEFNYLYMNKSNIEFMDNYYKIQPK
VGENVSKYLTPLHMEVFKENVNAAISLGFKTSEDILKTDGQDIYLYTTYSPVKNSRGEIY
AICCVTTDITGSVQEKEKFTELIYQDPLTNIFNRRKVFDYYKLVQQDNQKIWVLIFDLDN
FKSSNDTFGHVTGDQVLVDFSNLLKSTFPSSAIIARWGGDEFLVLVPNITYGSLRVIETT
IQNSITYLDELGVSVSIGEAFAEDTINNNLDYYIDAADLKMYERKRLQKGDYIRNSKVRH
Q
>A0A1N6MAM3|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MFSMSVSSSWFRCLLPILFIVAIHIGMGHEMFTQLSNSNVLLNLPYVLLFTALAVAQIFK
QSRMGMLAVAQILAYVVIQLCLQTPLISGSTLLELSLLALLFPISCVICYAFHDSDLFTK
EFLYYLLIQGLFFAWSLLILDYFNQGDFPELFTQLLLSVPQVSRLPFILFLYLIVLGGLT
MLRLLRKNHKLDAIVYTSVLLISDVFVSFHLPHISSILFSISGIFLVLYVIAAGHELAFN
DRLTHLPGRAALDHTMKSLGRHFTIAMIDVDHFKQFNDNYGHDTGDEVLKLVASKLLQVK
GKAKAYRYGGEEFTIIFKGKSSEEAFDYLESLRQDIQNYDMYLRNTDKRPKNDKVGRQKR
QKDQSNGIVNITVSIGISDSRSTRNPQEVIKSADQALYKAKKSGRNQVSV
>A0A5W0NS01|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae serovar 18:z4,z23:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A4Z8YPB7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V3U686|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Havana|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1S8SK79|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MVNYIIFLAMFLTAFVSAQLCIFLFYKKRRIHLNGLLGVILSVFIYSLFYSFELICPNLT
FMKLFTGIEYIGIASIPAFWVIMALEYTNKSRYITKKLYMLLFSLPTVLVALNITNDYHH
LFYKSYTVDIADNLYIANLKPGIVYVICVIFVNVCFIVGNSLYLIFYRKENSLYKKRSFK
IMLTSFIPWVGYWIYMSRITSIRIDIVPIFMGVFCLIYTYALFKSNIFETATIARHVIFD
NISEAILVLDQENKIIDMNNIAEKIFNIKSKLAIGQDVCTEFKEYQEIIQYIYEEKETSF
NCEIKIKNKLYYFKGKLTLINNNRGKGKVIVLSDNTEQVLMIKKLEYYGITDVLTGVYNR
KYFYKIAKEKIEACSDKKHMSLLMMDIDKFKTINDTYGHPIGDIVLKKVMNICKELLGKK
YYIGRYGGEEFLILLDNANSEKALEIGETIRRRIENLEILHDNKCIKITSSFGIFTSVRE
RDLENMIKFADKALYEAKSLGRNRVSIKMGNS
>A0A379TXL4|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDDAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A5X4CLA7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQVGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQERKKK
>A0A380U287|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MIKKSVFHSLDLQKLILILIIGCVSSLFLISIFVLNYVIKEQLTENSLAANQRYASKIAF
STDKYFESMLNELRYSAQIVGQDFSNQQVLKAEVTRLKGQSQKFNSITIIDKNAFILEYS
PETLHVNQKKQYKTPGITEALKLKKIYISSPYKGLSNNLIVLIAQPIFNRKNEFLGIVTG
SIYLNKENLVSELLATTYSYKKSYTYVVDNKNKIIFHPDKARIGDSLKNNTGMQYITSHP
TGKIALVNSKGIENLAGFAAIPSVNWVVVSQQPTLELLSQANSIIVKVTLAMLGFYLLLF
IFVWKLSYWISSPLNKLAQMASMLTRPNIDQDIKNINPWYFEALRFRTALLLSSKHFKDE
IAELKQHVNTDPLTGLYNRRGMKLFLNELEATNTPFSVLTLDIDHFKAVNDNYGHDQGDH
VLKKLASHMKSNFRQHDVCCRVGGEEFIVFVVHEDPKIAYIAAERLRKTVAQSYIDPIGT
ITVSIGIASWPQDSENIQKVIKLADQKLYQAKNDGRNCIRSTSSD
>A0A7W3GWE1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIQTPLAFDVLQNAVSRFSSVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A0D6FSN1|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MKPGNAELDERIAALLADPAYAGHPLREALQDLWRHTAEQMSRIERITHLSDAYQSMAHQ
REMGLCEQFDRQLRRLARIARISDHYQNMMRDLNATLEETSRRDPLTGLLNRRALMELIK
QEVQRAARGGQAFVVAMLDVDHFKAVNDRYGHEVGDRALVELAGAMRHSVREYDLCGRWG
GEEFLVLLPATPPETAQGVMDRLVGAVRALAIDVGADVLRLTVSIGMAYHQLGETFSETL
SRADQALYLAKQDGRDRVALGFPRR
>A0A7Z8M004|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7Z1EJY4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A729JWR8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 48:d:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A729PX29|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 48:d:z6|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMGMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7U4S4I0|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MTSQSWRSLVHRKYQLSLRLFLFLNATSAVFSVTNPLNSVRLLSAPLIAIFSISTGLFVW
HWRKRARKINIPVVSGIFGILWAWQIVSKFALITHDHATYLLIALLTVLFIGTLAFASNI
KAFTLHSLPTFIACLWLSDHDIWLRMTYSFALPVVAIAIHNILQTRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPTVENGEHFVLLMDIDHFKAYNDHYGHMMG
DQALKRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARQTAERIRQKVYDLKIPHL
FNESVATNVTISIGIAIFEDEDVEGALEKADKALYEAKHMGRNNILLSEELQTA
>A0A379SFK6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MCGTSANSAITALSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGYYRGWLKSADMAL
YKAKNAGRNRTEVAA
>A0A3T2YPA5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A127MZC9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MSTPSSPLKQRALQKLLFRRFGMALGTYAMALLLLWLTVIGDFYHGSPALALAATLCAVA
SQAVFFWLFASGRNQRFVDASLTEPQVLVALVWTTFFLAHVDSVRGTLMVLYVLILLFGV
FQLQPRVFARCAGLAFIAFAGLNLWEAFRQRLQLPGQAVLQLLVLFIVLVWLTLFAGYVQ
ALRQRMRQRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLAGRALDDLDEGQ
RHGLALIDLDHFKRINDVHGHSAGDRVLQTFAAVARACLREGDVLARYGGEEFVLLLPEA
DSDRLAACCERLRQAYAAAEPMGVEVPVLSLSAGMTLLHSGDDLDEALQRADQALYRAKR
SGRNRCEAAWEESDA
>A0A8F6XF39|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3U9NP33|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5F1I0J9|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRAYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALSFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPQIKPNWQVWYDCVL
PEDREHTEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSSIG
SVLVIQDVTEARKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVHSTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFMWEGRLHRVGASAGMTLINDSNHQAAEVMSQADIACYASKNGGRGQV
TVYEPQQATAHNERTVMSLDEQWRMTKENPLMMIAHGIASPRITETRNLWLISLKLWSSK
GELIDEQAFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSVAGLGSVTLV
DELLEQLEQSSLPPRLFHLVIPAEAIFDHGLAVQKLRLAGCRIVLSQVGRDLQIFNMLKA
NMTDYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVLDTLSDIGVD
LIYGDVIAESQPLDLLVNSSYFAIN
>A0A0F7HG60|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MKTPEIPANEVQRLKALRSLHLLDTLPEERFDRVTRMARRLFGVPIALVSLIDENRQWFK
SSCGLGAATETPRDLSLCGHAILGNDILLVPDTLQDARFADNPFVKDAPHVRFYAGCPLS
FSGNLKMGTLCLIDDKPRLFDAEDAVALRDLASMVEDELRAFQASTSDELTQISNRRGFI
SLAGHMLHHCQMKGVKASLVFIDLDKFKLINDTYGHGEGDRALVYFSELMKQVFGYFDVI
ARLGGDEFVALMGNRTKSEAEQGILALQRYVDEHNASQITPYQLAFSYGIVEFDPAAPHS
LETLLAEGDSTMYRIKKSKCMRS
>A0A3Z1X579|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3L9P373|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPSLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMHDALETPLAFGALHDAVKRFAHLRTSPTWQIAVDK
RRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYHHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSESPAVDVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFDQAKILA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHLKK
>A0A1B2JYP3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MTVQSWRTLRTKKYQLSLRLFLLLNAVSALFTLFFPLFAVKALSVSALLILVMSTLLLVW
HGKYADKRINLPFISIVFGLLWALHILLKYNALGQNDYYFLLIALLSVLFIGSIAFANNI
IAFTLHSLPSVAVCLWLNGSEHGLRIFYFMALPMAGIAIQHVIQKRYDGFAQQLMYKLLE
ERETLNGLSMLDPLTGLYNRRGLQHRLDTLLALSNSRHFVLLLDIDHFKSYNDHYGHMMG
DQALIRVSAAIRDSVRSRDVVARFGGEEFMILLTAVDPQQAQAAAERIRQKVYDLKIPHM
FNESVATNVTVSIGIAPLVEQDIDAAIAKADKALYEAKNLGRNNTLVSDELRVNCPST
>A0A5Z6IX51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Johannesburg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A332KJL5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A086I5Z5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A431SN23|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MTSQSWLSLVNNKYQLSLRLFLFLNAASALFSVTNPLYSVRVLSVPLFAVLTASTGLLIW
HWKNSTRKINIPAVSAIFGFLWAWQIVSKFLLITHDHATYLMMALLTVLFIGSLAFASNI
KAFTLHSFPAFISCLWLSPSENWLRMAYFFALPVVAIGIHHVLQRRNDRFAQELLSELLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPRPDAGEHFVLLMDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVARFGGEEFMVLLSNIPLEQARQTAERIRQKVYDLKIPHM
FNESVATNVTISIGIAMFEGEDVDGALAKADKALYEAKHMGRNSILLSDELHIA
>A0A4U8A6F9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Corvallis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7D7A890|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>W9BJH0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTKGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYHYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A332YW72|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRSVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A376P7J5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A094XXS4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A4Z1R9X0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0C2B5R9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A6C8RIQ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIELLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>C3T9U2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A1Q5ZPU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2A6DRG9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A853SR04|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MLMTTLMCGAMSIVMFSVYRSFRREVHGLGHWAAGLLLLVCASLLFGTREVLPPALSIIA
ANAALVAGIGLSMLGTEKFFGLAPSRRAYLLILVLAIAGNCWWLLAHPDFSARVAVFSLL
VFLFYARQVQLVWRHGERHFSSFFFGALMLMQAVVVLVRGVSALLHGGASVNLTVAGTPA
GIYLAVANFMALLLTVGFMTVATRRLQQILERRSTHDPLTQVLNRRGFGDAYAREIGNLR
RRRLPLTLLSIDLDYFKLINDRHGHAVGDQVLAHVAAVIKGALRESDCVARFGGEEFVVL
MPDMPVHNALGVAERIRALLREPSHAGLPPCTVSIGVACQASVVEGLEQLLSRADAALYL
AKERGRDRIELDACAFTEDRTMSAAGSGTGR
>A0A826P995|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIVHGIASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0D0MLG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2S8TIL0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHQQGG
>A0A380A7E2|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MIIHAPAVSRLFATRLQDTDPMWQISQECQAGQLLSCLLATAATSLFFMLLYLWLFKSDA
AVVINLLGLAAHVAIVADLWFYGNLRRSQWLTVLVPTCIALAMSLLLGTQHQITLYLLLS
PILAFLLLGRSRGLLLSLGLASCIWLMLTLNQNLWQGADSLAGLGVVNFFAAYTMAVGIG
YTGERIRHRSFKRLEKLANTDPLTGAMNRRRFFENWRRAKAEANRGLSEFAFLLLDIDYF
KATNDSYGHDCGDAVLQQLVQLLEDRLRPYDLLGRLGGEEFGLLLRGVSAADAERKAEEI
RTKVAEHNFGNEQVPHLPITVSIGIVHMPRRHGRSIESLYKQADMQLYHAKRAGRNRVVL
AEKIFEPA
>A0A1X0YSC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A5W3HWL6|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A826USN4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDNQQNIIASWRYTAREPGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAVRETSALLFLDGDNFKYINDTWGHAT
GDQVLIEIATRLMEFSGKRHQAYRIGGDEFAMILYGVLSEYEVQRICTALTQTFHRPFDL
HNGHQTSMTLSIGYALTREHASAEKLQELADRNMYQAKHQRAEKLVK
>A0A0F3V3V8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHS
>A0A239SC13|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MPDAMPAVPSPNATSATAGTSAAGVTDDALMFDLAPVSLWLEDFSGVKRLFDEWRAQGVV
DLRAHFKADPAHVSQCSQRIRVIKVNRRTLAMFNAPTLDELVANLSRVFRDDMLKTHIEE
LCQLWDGHTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEATLDRVLISLENVTELEHARER
VTMGEQYARGLFEYSPVSLWVEDFSAIKLLLDDARARGITDFRTFTDVHPEFVERCMQEI
DVLDVNRHTLAMFVAPDKATLLGRLPDVFRDDMRHNFREQLIDLWENKLFQQREVVNYAL
DGNEINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYV
DELNRLERKGPYPVTVVVADLNGLKAVNDQLGHAAGDALLRRAGEVLGKAVAAPQIAARI
GGDEFALLLPSTDETGGAAMIESIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEATIQ
RADLLMYEEKRNHYAGSVNERRVLDGAPSGKTGRGT
>A0A0P7P2K8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRTICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A418U1B4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSDDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A2Y0MHK7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNTIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A148HXY8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKISQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3V9PQG4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bredeney|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A241QQB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A0H0FQ64|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A826R142|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENRWQDAHFDEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLSAWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQRVDTHAIAY
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVITRV
>A0A376HPK5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSL
ADRRLYLAKQAGRNRVFASDNA
>A0A2A3W162|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAISH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0L6Y6G0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDSYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A376PVN7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRMFQEGHLLRNSIAIFVLTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLLAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEVVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGQVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A827KPQ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQSVITRV
>A0A447XDX7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEQDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A4C9C8W7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQNLTFSQLRIGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLWRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1Y5KXZ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MLAARFHVETCSVHMAKNIPTIFPGTPPPEAAQTLLALLHAQGEVARLSERDQLFSSLLD
SVNAVLWAFDWETRQVLYVSPAYERIFGRPVSLVLADYNEWRDSIYPDDLEFAERSLAQV
LLKGAVEDREYRILNADGQLRWLSDKCYINQQHDGDRVIIVGIAEDITEKKQLEGELQRL
ATTDVLTQSSNRRHFFECAQQAFDSAREDGTPLAFLLLDIDDFKRINDSYGHQEGDQVLQ
HIADSGKAVLRRGDLFGRIGGEEFAAVFPGCNAQVAEQIAERLQRQIQHLSFSHGQQTYG
VTVSQGLTELTDEDVALDSLYARADAAMYQAKRQGKNQIVRG
>A0A2J7YF60|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MTHTKHGLRLDLRTLILVLCALTAVVMLCASYFASYRVQRQLLIDNALEANRVYATKLAS
ITETFIGNALQQLMFSAGVQSRQLSDTTALQLETDRVLGQSMAFNSTFVIDANGVLLAVS
PAPLRHLLGTHVQSPGALEALRERRPLVSTPYLSAADNLVVALSQPIFDSNGNYLGYVGG
SLYLRERNILNSLLGEHFYKDGSYLYVVDRNRRLLYHPHSERVGTVVEGNALVDQLATLD
SGTRQLTNSLGVEMLAGFATVPSAGWGVVAQQPLVQTVAPLHHLVLNVIASSAPLALVGS
LLLWWLARTIARPLWKLAAGARTMDRAATAEHLHQVRAWYFEAAELKRALLFSLNLLQER
IGRLNRDAQTDPLTGLGNRRSLEISLSLLEAENREFAAIALDIDHFKRINDSHGHEVGDQ
VLRQLAELMRRCCREGDLLCRTGGEEFLILLPGATLNVAAAVAERLRVTVQDMPVEPVGA
VTISLGVTHWDGETHGEPMNALGEADRALYRAKQEGRNRVAFA
>A0A5C5HL87|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Z7U1Z1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A742TWE0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGIVDALQNITEVVHDVRTNRNFSRRVSDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0W4JRA8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Z7WG09|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A745MIJ0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVFCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3T2W987|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Orion|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q4ED16|diguanylate cyclase|EC 2.7.7.65|Wolbachia endosymbiont of Drosophila ananassae|TrEMBL
MTAKILVVDDVLSNVKLLEARLKAEYYTVIVAHDGEEAIDLVAKQQPDIILLDIMMPKMN
GFQVCKELKSDPLTTHIPIIMVTALHDTHDRVQGINAGADDFLTKPINETALSARIKSLT
RLKMIIDELRLRGETNAEIGGVAGNSIMDYSNQIFDANILVVDEDVFQAEQIYNVLKQRF
RSIKILSDPIEALKVGIKDNYDLIISDMQFSKTDGLRLCSGFRSKVETRYTPILILSEDY
DKNNLVKALDVGANDYLTVPLDEGELIARVNSQVKRKRYQDALRMNLFNNAEMSIKDPLT
NCYNRRYFDAHLRNIVKDSVEKDRRLSLMILDIDYFKMVNDNFGHSAGDELLKQIQRRIS
ENIRVTDLLARFGGEEFVVVMPDTDTSDAYTIAERIRKIIAKKPFILADKNTTHNVTVSI
GIAEMQGSDLDNIKEFIVRADKYLYKAKNSGRNRVVTG
>A0A5V1GME0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A265DY36|diguanylate cyclase|EC 2.7.7.65|Halomonas boliviensis LC1|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAVETLVENHCHRFADQFYRVMLEDPHASLFLSND
QVEQRLNPSMRRWLKAMFSVEHADFEALVEQQEKVGQVHARIDIPVNLVLNGARQLKQAF
YQQINATLTSPLSTGDASVYVSEHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQNIG
DERERQRSALLNWENALMFAVAAQQNIATLPKLANSDFGLWYLHKACHAFEGAPEIATIS
RHIQQVDREWLEVLLHDDASQRLKALGEIRDATRTVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLPVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDSGDSVLQQVASILDRS
TRGGDYVFRMGGEEFLIVQVNTDYEGSRLFAERLRQSVAKEPLLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYQAKRGGRDRVVVQ
>A0A738DFS4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>G4T3N0|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MIDPHRLSTQLIRHLYRHSTRDLAVHCVHTGLIAAYLWFELPLSIWGAWLAIALLAGFWH
WYRSTQALRHIPDDTIKGDTIVPDIVAAGIAGLSLGVSALLFPLLSLDTRLFVFMMLSAV
AAAAMPRLSTLPSVYAAFLFGILLPLIGILIVMDNEPGLSSIPAILILGGSLFYSAYRLH
SDLMDGLLSRFGLENEAGQDKLTGLANRRRFDFVLQQEWAHALRYRTPISLIIMDIDFFK
KYNDHYGHQEGDDCLEQVAGALAESVKRAIDLVARYGGEEFVVLLSKTARDDAYAIGERM
RQAVEDLEIAHEQSTLGHVTISLGGFTTFAREDMKAEDLVKLADKALYRSKESGRNRVTW
YDPKLDDPETAEL
>A0A8E6KM48|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000541|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6S7AJ72|diguanylate cyclase|EC 2.7.7.65|Achromobacter deleyi|TrEMBL
MSSMSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSAHALVDAFY
STLLADAEAGPRLSHEIVSSRLHKGMKHWLKGLLCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALGQITEAVSRLDDVVLPRLLQGGQAGQPSLPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATREHSAFSVLLLDIDHFKAINDQ
YGHSGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALAVAEKLGAEIRR
HAFSIPEAGALRITASIGVATFDGHPDYAYLIDRADKALYQAKQGGRDRSVAA
>A0A6L3PER7|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIAGFKAERDKPEWTLPTGRDLAPEIQ
GVSDTFIGQSTLLERDDALLYSELNATLALGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTASIPLDDK
GRWFGVLAMDFPIGAMRDFLKNALNADDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTADGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>T0R3U8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MQEETSESMPDPPTQGQLNPNELQQLFELAPFGIGVFDRYFRCRSVNQTLADINGLSRED
HYGKYLRDIVPTLAPVLEPLFQQIISSGIPQVELSLSGQTEAHQGQQRRWQAIYSPMLDE
QGTPDGILTIVRDVTEQYEVQQRLQLAMSAGQIGVWEWHVAEDRLQFDGQVERLLGTAAN
QFQGGMDNFIKRFDPVSGEQLRTALNGTAPLHLTLSYLGPNQIRGWVDLHADHVAATDTQ
GRRIMGVIHDATDRCNQEDKLRQANVVFDTTAEGIIIMDGQRQIISVNPAFCNMTQYEPD
EIVGKSPEAIMHPRRHTDIDYPWHTLLPGSHAWHGEMMCLRKDGDYFTSWQHVSAVYDSR
HNTAHYVITFSDISAIRKAEAQLNHLAYHDPLTELGNRNLLQERLELEIKTAQLNRQQLA
LLFIDLDGFKLINDNLGHRAGDQLLKLLAGRIRQSLRHNDVAIRLGGDEFLVLIPYFEQQ
EELAQLAEQLLARLREPVELEHEQVAISASIGIALYPEHARSPDALVSAADNAMYEAKSQ
GRNGYLFYSPDMAEQTRERMSMEQGLLKAIDQHQLCILYQPMTDLANNRLSGLEALLRWQ
HPSEGMIAPARFIPVAEECGLIEQIGEWVMRTACQQGQAWLAAGLAVPRLSVNVSVREMR
AIGYVERVAAILAETGFPAERLEIEVTESIIQRVDHSLQLFTRLKALGVQIAIDDFGTGF
SSLSLLKSLPIDRIKIDQTFVQALPDDKHSRELCRTIINLADSLGMAVTAEGIETQAQRQ
FLQSLHCQEGQGYLFSHPLTEPHLAAQLTPRKGVWC
>A0A822J1J2|diguanylate cyclase|EC 2.7.7.65|Methanosarcinales archaeon|TrEMBL
MVETNLLWMKKSYFDDTIDGELHAAIDMDSYKSNMERKLKESEKWQAAIINNIGDAVIAI
DEKGFIKLINPFAEALTGWSKVDAVGKPLKEIFNIINEKTGEIAEDPVIKVIREGTFFGL
SEQTTLVNRNGANIPVDIIGLPVLDDENNIMGITLVFYDIVERNKMERAIFCK
>T0QX23|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MVDYFQGSLFHFSERAQYLAALLNSLEDQIAVIDRAGVIHYTNLAWNRFAEQNGMPKGYD
WLGINYLRVFDSAVEPLVLMAAEGIRRVLCGEQDHFHLEYPCHSPDIQRWFMMRVSPVLG
VDVEFYTITHINITERKLLELDVTHLSQHDPLTGLANRRLFNSFLHNEWRRSMRERTPIS
FIMLDLDNFKACNDHFGHQVGDDLLRQVGHLLNAFCQRPADLPSRFGGDEFAVVLGNTGK
EAALRMGEAIRLGIKELSMNELGDARLSASIGIATQLPERVLVSEDELLAAADMALYTAK
KEGKNRCHSVACPSLPNP
>A0A2D1QL22|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKAKTKAWPLLVVLYLSILLFTGSTLYCLAQIQNATRVMEKYTYDVSWALMQLQLELGRF
LNSVEIYHYGGIDHDTLMLRYDILWSRTPILLSGQLRQSMKDKQKTLRLVQLIESNIREM
ESNITNLKSGTPEYQQIMMRLAPLQEPLSYSLASVMQKNINVYSGNDKRFGQLRNALLFM
VSGLVLSVMLLSGLLIREARRHFRAARVDPLTGLVNRLALLEKMESYATKEIPFGLVLVD
INDFRDINSKFGYNTGDFLLQEMAKRVRGLCENGEWVARLGGDQFAIIQRESSDLRQVRE
LVVRLLHALKQDIIIDNYPFRLEVGIGIAFFPMDSKLTQELLSRAEQALFHSRKTHVPYV
IYDNSLLNETARRKHLASDMIMALEHNALELYYQPIVNLESGRCEAVEALLRWRHPELGF
IPPNEVIQVAEEFQLAEKLGSWVLNTACEQLYQWQQLGLVDLQMCVNISPGMYQRNLLKL
VAKALMDHHIPAASLVLEVTEDTTMREVKNSLQLMQDLNQQGVQLALDDFGTGYSSLSYL
QKLPVSKVKIDRSFIQGIDTSIEASELVANICRMGSMLGKSLVCEGIETQAQLDVLRTLT
DMHLYGQGYLFSRPEQAEKIYQTLLEMEEAWLKRRQPGKAYLI
>A0A1V5WC31|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin215|TrEMBL
MAFEPGRIYNAYRFVYPLILDGEHYGSVELSFSMNSFLDILSQLEKADYYFGIRRDVVES
IIFEDDRTRYMDSYFSPEFLFDREVLPEHDNKELFEKTADLLHPILDSGQNGGYAAMHQG
SRKLVLVHFVKDLSGRPVACFVAVSDDTVLSNYLRDYLVIIGISVVIFLTLFGAALILFR
EREKMKHLSLTDMLTGLRNRTALVRILEQEMDRVKRYEKPLSVMMIDIDNFKQVNDRFGH
AEGDTVLKNLARLMSSALRASDYAGRWGGEEFLVLLTDTPYESGVIAAENFCAEVASTYL
STLTPVTISIGITAHIADDSIDSLIARADDALYEAKRQGKNRAVGIRKN
>T0PJX9|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKAFFRSQAQRLTLRQSLGRTHMVTSLTAVCMAGLLLTGIALLALRIYADHNLELVARAI
SYTSEAAVVFHDEEVAKEALQAIVTREDVAQASIRLPNGRLLASWSRAMTTPWSGLEQYL
AQLILPGPVEHPMMRGGVEIARVHLIALARRVQHQLRSMDLVCRLGGDEFAILLTPLLQE
SEAQDVVSRIQLAMADPVVLGDGRQLVAAISIGLAVYPDEGLTAGELLQQADNAMYQSKR
LRRELALHDQLEFDVSAEEK
>A0A8B2T1L2|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MDKLMWVEKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMRSALGTPLDFAALRKAEEDYLTKRHDPIWSVEIHNRRTLPI
YGVADAFVDSDALLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
ELPKNSTQALALYSRATGAAWFTRQTQRNNPARGIVWQTFPDDESQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTLMLLISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERAIAETRLSERLK
RPVAVIQLDLDYFKSVNDRFGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TPLKEAQVIAERIRIRINSREILLGNSISLRNTASLGVSGSDDTGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A6W0NV55|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rubislaw str. ATCC 10717|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5E4U7R8|diguanylate cyclase|EC 2.7.7.65|Pandoraea nosoerga|TrEMBL
MPDATPAVPSQPPSSSTTPPAAPSLPSQPSPASDDALMFDLAPVSLWLEDFSGVQQLFDI
WRAQGVADLRAHFKADPAHVSACSQRIRVIKVNRRTLSMFNAPSLDTLVANLPRVFRDDM
LKTHIEELCQLWDGRTHFTSKTVNYTLDGRRLDVLLNGTVLPGHEATLARVLISLEDVTE
LEHARQRVTMGEQYARGLFEYSPVSLWVEDFSAIKMLLDDARARGITDFRTFTDVHPEFV
ERCMTEIHVLDVNRHTLAMFVAPDKATLLAHLPDVFRDDMRQNFREQLIDLWDNKLFQQR
EVINYALDGNEINVHLQFAVLPGHEARWDLVLVALTDITARKKAESYLEFLGKHDVLTKL
RNRSFYADELNRLERKGPYPVTVIVADLNGLKGVNDQLGHAAGDALLRRAGEVLGKAIVA
PQIAARIGGDEFALLLPSTDATGGAAVIESIRQLVELNNSFYPGTPLSFSMGMATCEAGE
RLEAAIQRADLLMYEEKRNHYAGTVNGRRSLDALAPGSGGSGGV
>A0A8E6VX84|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 6,7:m,t:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A533QNC9|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MFKHDHFSRLYPSRQASRRLHRRPALPADHQTAHVHAFSTVGDGGAQHRRMRRNRMAAPQ
ATMLELLAAEARIADLEHALRTAQAAAVTDTLTGALNRRGFDQAHDREAARSRRSGSPLA
LALIDLDDFKHLNDTLGHQAGDEALIHLVRTLRSALRPSDILGRFGGEEFVLMLPDTGLE
EAVTALTRFQRQLADARVSGSGVTLSFSAGVVVQAYGESFREAIERADAATYAAKRAGKN
RVFSG
>A0A7H4P5K3|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MKLQNKLLRYFISAGVVVLTSSFLVYELVASHRDMSEYMRYIIEKGESAFLYDKYQNQLV
ISQVARKLDTHPTAEKAQQACASVENKGKVFGLNIAGHTFPGLHGTLSTTQASCGPWINA
LPALQAFDAAIAQSDMNSALNATTFKSDKRFRYYLDLDNKYAYFYSPIEIKSNPVANWDF
LHDSKLGITQNSLNGLLRGRTLISSIYADALTGQNILSFLTPVYHRDRLKGIVMVDVTRH
DIEKLLYTADRPLVWRYLDITLTDSDSTSEIRVHRSNTHFFSYAHHSQKVAENLHIALSL
DMTYFLLSSWKLFLFYLISTGVLLHLVRMHFRLYIDVFKENISDSLTGLYNRKILSSLLE
SRMQKLTEQGVNIVFMALDCDRLKYLNDTWGHDEGDRAIVLLAQSISAAIRKSDYGIRLG
GDEFFLILIDYEEQEAQKYPRAYSPAPEGN
>A0A730ZII2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 1,40:z4,z32:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEFLLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0D6I706|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MPAAILMCAAGLCAAHFIGFNTLRWGGALACLGAGYAIMLVQAGGLAPYKQVVEDAFILG
GVILACRALQGRRGRHAPPCFDVAILLASTAMVVVSVVLFASAKLETFFVQACCALVTWR
ATLSFARHAATTSDRVLTAAFLFIALVLTGQCILYLAAPTPALAAGEWRTSVWGILIQYT
GLLGSIVLTFAVFIATSYDAIEKYRRHAHTDALTGLLNRQGLDNLLASSSARPLSDGPTP
TALIMADIDNFKRINDRFGHPFGDMVLARFGALLRPRAHAQAHAARLGGEEFLLLLPVAD
LASAAAIAEEIRADFVAQRWAPQAPDSRFTASMGVTLAQAGESFTSALQRADDLLYAAKR
RGRNCTVAGHAQADAGPGLAAFRDAASGESSTHDFEARAAVQRG
>A0A0M7EC75|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MLRSRFSIKSLERYFLILAAGVVLPMSVLTGILLIQSRTAYLASTDAMRAFGVVRATVVA
MEMVSAERGPMNAALGADYPVAQPMLDTLQQARDRSDTSIAELLALYRAPLSPNSAREFT
NVQRIRHALLKAREQADIVIATRRADVSGLRVQAVVDGMVALVPELQAAMAASVGVVMQN
EADAPNLLTLALLASELREQAGLLGSAFTPALAKHRQLTEADEYRIERVLGRIDQLRDLL
ETRMATRPDLRASLAYNDMRHFYFDEGMRYLEEVRDMAALQPGGARLTTRELAAAYVPLM
HAIGQFRDLMLDQMEQSMRAHRAQAMRLLLITLVAATALAAALMLSLRQFRRRVIRPFVQ
ATRIIGAIADGTPAATIPVGKYRGEVNGMFEALSVLKDNAAARRQAELERDRLIVDLAVM
AETDFLTGLLNRRAFESRLEQALAQWRGTDAVLAFILFDIDDFKGINDTHGHASGDEALK
TVAGLCRQTWRQADVVARVGGEEFAVLCHVGAADHAVQAAERMRRRIAQARVTAQDGAVF
TLTASFGVAYASWRNAEAADALFRRADELLYRAKMGGKNRVVPGEVG
>A0A7Z7PQU0|diguanylate cyclase|EC 2.7.7.65|Mesotoga infera|TrEMBL
MKKIVVVACSNFQQEMLEISTREEFQALSFYFYPALCEVSPRSGMREILNDVLSSSGEKL
HFLFAPRSCPILEHLRERPEITHIAYDFCQELLAPKVILQQQIKRNSYLVTDGWLSQWRE
HLRNWGFDPSKNSSFMSEFSTLIVHLKTGVIENPERELADFAKAVKLPTDVIDIGLDYVK
NFVLASVYDTIARKMGLFEEAFDFDLHRQIANYAMINEVLMEIASLNSKNEVLEKISTLA
EMLFAPEEVLFFEKFRDGWREIYSSARGSTITEEVLQIPENPEDIFSLECGRDLWMKVRH
DDKLLGALKISKIAFPEYSDRYLPVLGNIRSVLGLSLSNAELLEELKTISLTDPLTGIYN
RRGFFDKAKAEFLKASRGNKSLSLAVCDLDNLKAINDSFGHEVGDLVLKEVTSIVRDNIR
ESDVFGRFGGDEFIILFPGCDSKAALEVLDRIRVVVGKIKEPLLNGQELSLSFGLTTIRE
DTGSLEELVSLADRALYEAKNSGRNAIKFI
>A0A142XCB0|diguanylate cyclase|EC 2.7.7.65|Gemmata sp. SH-PL17|TrEMBL
MNVTRYKCSVLAVDDDPAILAILTGQLGGDFDVITACSAEQARVTLSKRSVDIVLSDLQL
PDETGLSLLDWVRRTAPRTARVLITGTARMQDAVDAINHSQVHRLVLKPWRSEDLLQTLR
AISRSLLLERSHEHLLDELRKLNLELEQRVQTRTQELEHALGQLQQANLILERMAATDPL
TGLANRRAIDAIARKELQRRTRLPGPIAVLWIDADHFGRVNKDYSQIAGDQVLVWLAGIL
QSSIRTIDTLGRVGGEEFMVLAPGTDVVGAEALAERLRTSVEAAQTVYLGHTIRMTVSIG
VAVAEDGTPAGYEQLREIAAQTLKEAKEAGRNRAIIRLIPPPAA
>A0A823BBZ1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGV
>A0A8E2P4E3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7G6K6P2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLCLQA
KNAQLLRTALHDPLTGLANRAAFRSGINMLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2X2I5D9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGWWIYQIWNASVN
>A0A3N2EWN9|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. BIGb0399|TrEMBL
MDKPLWVSKLLRVSNPGHVVNYCFVIVLFFSTLLIWREVMVLEGAYVTNQRNNLENVSHE
MDSLLQFNIDRIVFFRNGMQSALETPLDFEILRNAEQEYMAKRHLPIWSVALHNRRTLPI
YGVSDAFVESESTLSRNDTQTGNEMMAALELGYLLRLANTNRGFKDRMLYISRSGFFTTT
ETPKSLALAQEWYSKAIVAPWFTRQSLRNNPGRGVVWQTVLDEDTQTDNPVVTASIPLDF
EHDWLGVLSMDFSVREMKAFLVRAIKGGQEGEYQLYDGKMNLIVSSDEGNVLAQLSPREQ
AMLSYAFLHDNRGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGDFGTITIALTLMWL
LFTLMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFDRAIAAAKTCEQSK
LAISVIQLDLDFFKKVNDLHGHQAGDRVLSLVASTIAGNIREGDLAGRVGGEEFCIVMPG
TTSQVARAVAERIRLRIYSREILLCNDTSLRISASLGVSSSDETGVYNFETLQSVADNRL
YLAKQNGRNQVCFAETL
>A0A2P9H7C3|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MSHLILPRVAAPGTYSPGKVATVCYLVIALVFVNDILSGSEVWFHGLYIFPLAALAIHTK
QRGLIVLGFVLSTMLQAITFISYDISLSSKITDTSIAIVSSALILYFSTAVRDGYYETLL
LSTRDPLTALLSRWAFVSRLEAEIARQGRYGGVFSLVSIDLDNFKTLNDSYGHALGDEVL
KLVSTVLRENIRAVDSLGRLDGDQFAILMPQTTEADCAARSQNLTIEIARRLASIGFPCT
ASIGFTTCDRRLGSASDVLARAERAMYAVKAAANLEPKAS
>G0EUS9|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MLHDAGQFLALVNPAIAILLSLCFLLAWNHERTRHYLLQLGACYLLYALAIALQIVWVPR
NGGGNATVTGALYLGSAVLMLRGMLARIGARVDTCALVSLPLALFATLAWFDFVQPQLVA
RIYILNIGIALILLLGIAPLARLRTGSTADRVLFWVFLLFALHFLPRTVLTIAPATGQDA
AAFTRSAYWLWLQVTLALLLLTLALALLAAAMQDVIDGLRHERDTDPLTQLHTRRSLEAL
AAREIPPPQGKPLSVLLCDLDFFKFINDNYGHSAGDAVLAQIGRIIAAGVRRRDIAARLG
GEEFVVLLPDTPPDAALHLAERLRQTLESSEMDVLPGMHSVTASFGVATLRPGEDLEALL
MRVDNVLYAAKNKGRNCVEWEREAGMPVLA
>A0A378C048|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLSTAGELDQTWYQARFFETLC
TLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHP
LSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTG
EKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNSVTAEACVQRADEAMYEAKNNG
RNQVIVWHRQGG
>A0A447S609|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAPGAGNRYFFKHSRPPGRRF
SVRHPLRHQPATTAL
>A0A378AAN9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWSEINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVIRHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAIAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A331AGH8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRSVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQSLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A2X3INI5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQTLSVTVSIG
VAEHMTAKRLINCFPRR
>A0A378A2W5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFFRN
IMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVNFI
DDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQLLS
TAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLYNR
SFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVD
DAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNSVT
AEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A862ZK34|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5B9P5G0|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MSNILLENLPSPPEVAIKLLDQFAEADVNLNELEKTISAGPTLAARIVQFANSASFARQR
AATSLKQAMMVIGIKGVKVLALSFSLTEMGESKQEGRRFCFNEYWRFSLACAVSSKTLYR
EMSKDEETGFLFGLLMNIGQLALACSQPDQYEEMLGETSMNDPSLIEKEISTFGLSRYEL
AQAAMESLGFPPSITAAFKEMNAGNRDRPEAKIIEVTHAMSCLFLNEDLDGNAVRDFSEK
LAELTQNGLEENRQSYDTALEEYKEIASVLSYKSPSPKSLKEIENEAKHSIIQMTMALHL
DKAQVEKENDELKDLAMLDELTGLGNRRQYEQMIQSEISRCNRLNRQLVLWIIDIDNFKS
INDTYGHATGDAILIEVASRMGRSTRGYDFLFRIGGEEFVVIQSESTVDTCEVVAERLRS
EVANRPFVVDDLEIPITISLGGAIFGYGSATTKEQLFELADKNLYAAKNGGRNQFVIDRD
TELNVPTGPTNQFFTALHAENS
>A0A087CWU4|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. saeculare DSM 6531 = LMG 14934|TrEMBL
MARLLIIEDESELLHALEQLFVHDGHDVLTAADGEQGLRRFREGRVDLVIVDILLPKLDG
FAVCKAIRHGSDVPIIVTTALDDEGHQLQGFSLLADDYVTKPYSLSVMRERVRAVLRRCA
ARSDAAASPAIEPTTAAGPAGGTAASAAECGTGTAARGLLGFGDIIVDTEAHEVLLRGDV
VTLTRTEFDIIRLLAEHPRRVFTRDALARQVWGYADDCGNKAINIHVMNLRRKLGADSVE
TVRGVGYRAGTRHG
>A0A2Z2NH19|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MVVLAHPSVRSEADRLESLRSLNVLDSEPEAEFDALVRIAAKICNAPISLISLVDETRHR
FKANVGLPHITETPRSLAFCHYAIQQQGILEIGDCLLDKRVAANPLVTGEPGLRFYAGAP
LCLSDGARVGSLCVLDKKPGMLTEDQREMLMHLARVASIALESRRAVKELMVSESRFRCL
SIDSSQLLQQTSELAKVGGWELDLASNKLTWSEQTCRIHGLPADYEPQIDTAIEFFALKS
REKIRLAIERLMHDGTPYDMELQLLRADGRCIWVRVLGDAVKVDGKTVRLRGVIQDIDEH
TRQRVALQNAHERITLATDSGEIGIWEWGIRDNRLEWSPQVFRLHGIEPATESPGAEGWM
ELVHPDDKVRVMDTLLQTLDGTGNLVCDFRIVWKDGSVRHLRSTAHVKRNSVGRAVALLG
VNFDVTDMRRLSSELAQQQELLQVTLQSIDEAVITVDTQGQIVWLNPAAESLTGWACHDA
LGKSQELIYKIVHEKTGLMQESSVSACLREGRRVSRKHDLVLRARGAREYGVEDSASPIL
DAQGQLLGVVLAVRDVSEQRRLSQLMTHRATVDELTQTFNRSEFEVRLSALIDEVQERPG
EHALMFIDLDQFKLVNDTCGHPVGDLLLRQIAGILRQSIRHGDTLARLGGDEFGIILRSC
DAQRAGRIAQEICDSMHRSRFSHDSHRFRIGASIGLVPLDDRWGSMAAIMQAADTSCYAA
KEAGRNRVHIWFDTDHAMRARRGDAQWAERLEQSLDESRFELYAQRLVTMGSRVAGLNAE
VLIRLRDDQGNIILPGAFLPAAERFHLATRVDRWVLQKAIEALVELPDLSGIELLWVNLS
GQSVGDREFQRDAIQMLDRAGSDIRQRICLEITETAAVTNIADAAVFIEKLRTLNVRTAL
DDFGAGVSSFGYLKSLPVDTLKLDGQFISNIINDPLAAAAVRCFVDVAEVVGLTTVAEHV
ENAEVLARVQSLGVDYVQGFLLHEPEPIGQVLECATISSYASHG
>W6KB89|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MNTSPPINILLVEDNQADARLVELLLLEVGFPFQMRMAGTLAEGLAHLADVTWVTDIVLL
DVRLPDCDGLDGIAHVLELNPNLPVVVLTGNDDESFAVKAVKKGAQDYLVKGQGDGVLMS
RAIRYAIERKKAESKLHLAAAVFDAASEGILVVDMQDRVSTANPAFLELTGYSMDELAGQ
KPSFMRKDMNSPTLLNEINAKVDGRGSWAGEVTCEHKERGTFHAWVSVSAVRDPDGHRTD
TVFVLRDITERKRAEDTIWHQANFDALTDLPNRTLFSDRLAEAITRARRTHKKVVVMFID
LDRFKWVNDTLGHHAGDELLKLAAARLVDATRASDTVARQGGDEFTIIVDEVDEARNAEI
VARKILSELAEPFTVAGNEVFISGSIGLTVFPEDGDTVTDLLMNADTAMYQAKESGRNAY
RFFTPEMNSDAFERITLEGDLRGAIENDSLSLWYQPVVDLTRNEIAHVEALMRWEHAERG
MVSPALFVPLAEETGMISEIGLWALRAACTQIASWRATNFPPFRVAVNLSARQFHDPGFA
RKVLDILDETGADPTWLSLDLNEELMNGDTSQIEETLRQIREKGVQFSLDDFGTGYSSLS
HLRRLAVDILKIDKSIVAGMTSDSGDATLVETIVAMGHSMGATIIAEGVETLEQLNLLTD
QGCDLAQGFLFGRPVKAEELLDECARSLKQAAEVKPKPKPKT
>A0A1Z3HFN3|diguanylate cyclase|EC 2.7.7.65|Halomicronema hongdechloris C2206|TrEMBL
MDTQQQPLTNAPVNGTIFLIDCDRNHRRHMAEVLSQHDYLVYELTTGHDIWQQIETHVPD
VIFLDIELPDISGYRICQRLKENLDTRPIPVVFLSRLSDYRDKINAFEVGAADFITKPCH
PEEVLARVQNQLYLYRQRQQLSQQNALLLDEVRERTQIEQALRQAEAKYRSIFENSTAGI
FQTTEDGHYLSVNAAMAHIYGYGSPQEMIATITTIAEQVYVQPKRRQELIAYLKRFDKIT
DAESQVYRQDGTCFWISEDIWSVRDDQGRFLCYEGIVHDISERRQMEDELRQQRQQADRL
LINILPYQIAQRLKLGSRVIAENFDEVSVLFADLVDFTAASSQMTPQELVKLLNDIFSAF
DQLAAVHSLEKIKTIGDAYMVAAGLPAPRSDHAIAIARMALDMQAAIQRFPRPDGSPFQL
RIGINTGPVVAGVIGKRKFAYDLWGDTVNLASRMETTGEPQQIQTTAVIYEHLKESFTFQ
QRGTIAIKGRGPMTTYWLIGVKK
>A0A6S7EBA4|diguanylate cyclase|EC 2.7.7.65|Achromobacter piechaudii|TrEMBL
MDPILAGLSNSLPLAKTVEQLTRPLLDMLGSVTGLESTYLTEIDLDTNLQHVRYARNVGD
MQIPEGLSVPWSDTLCKRALEEGRMCTNDVASCWPDSEAARQLGIQTYVSAPVRTDEGRL
LGTLCAASARRQQLAPQAESVLKLFSNVIANFLQREILMEQLHSANVQLRSYAMTDPLTG
LPNRRALYEELERLEQRAIRDGGSVLVGVIDLDGFKGINDTYGHQQGDLFLQEVSRRIAG
ALRTSDMLGRIGGDEFVLVGPGPDATEGGDAIQAALSLEERVTAATIGRYQLGDAVVAYE
GASVGVVAVDPRGLDAEAAVRLADARMYEIKRARKNARTIH
>Q32FV0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTP
QIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A6B8N7P9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MKVKGHFSLKFVIFVPAVIASILLALTVKNYLDAVNRDIDDEYQRIETSLERATKVVTAL
DYSFSNYYKSGTGLLLEHNRKIEDGLCKMWPIDALLLAENKTLDIPSVDISYMLVGDKSL
CQQESALYQNVTDHVSMAPLLSFLHDIDDFLSGVHYIDFDGFIMSSPDTLAKQITKPLLN
STLVRARGLFRKHDISKDNIVIYGPETLTNPAKKRLNISSPVVSQIDYEGLLTLQIDLAR
LLQSEVKLASDIHLINTSNSKPSGRAVREYVLGINGIVSSHMLYYELDLRAEIKNFFVFE
KYSLIVTGSLYILLVTVLFYVNTRVERSYFRELAARDPMTGLLNRRGMEAFLRNTTHSEY
LALSVLDIDNFKSINDAYGHDVGDDAICFMAEQIEKNIRDSDAVARFGGEEFVVYLRGRD
VEKMRMTMERVREAISRYSANVVEGGFTVSGGVEIVRTEENSDFERLFKAADEKLYEAKN
SGKNRLVF
>A0A6B8NEK1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MGIHLDITTLSIICVLLSLCYCIGLLLIQQLQPSVSGISTIASALLLLSVSFFLLSFGNQ
ITHWVSKILANSLMAFSYIILLLGVCQFRRFPRIIANIGFYSFPILIVGLTYFTFFMPST
NARVILMTVYVSSLCFIAILANQKGKSTDITPSKFLLSLGLATQGGYNLFRFIWTLFEER
IDDFMISGMAHQLAFVSTLLMVIFIGFSVTWMLTGRLVATIYDTSIKDELTQLYNRRALE
ELLPKEIARSSRHKQPLSVLLLDIDHFKKVNDTYGHQAGDRVLRTTGKLLILQTRKDDLS
FRYGGEEFLVLLPNTDVEKAVIVAEKLREAIKRARMLPTNVDSCTASFGVTQFNGEDDWQ
TAIERADQALYSAKENGRNQVTART
>A0A4U9HUL2|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MLAVFMATWLTQGMALFPQVSQRTMYATLPLIGIYTVALSVLTNSIAMRLRFKSRELERI
AMMDPLLDIANRRLLEKRIDHELHKLRQTCSDSALMFIDIDNFKEVNDRYGHKVGDMLLV
TVSQSLHIATRPERYPGPAGRR
>A0A6B8N5Q3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MKEPDFPDNEAQRIKDLHSLDILDTEPEERFDRVTRIAKHLFDVPIAVVSLVDNHRQWFK
SCIGLPVRETARNVSFCGHVINDDGPFIINDATKDPRFLDNPLVMGEPFIRFYAGVPLVY
HNQSKLGTLCIIDTKPRELTMQQMADLVDLAKVAEQELEATIQATLDPLTQISNRRGFFE
LSEKSMDYCRMGGFCVALAYFDLNDFKAINDKLGHKAGDEALQKFADLMASSFSDSDVFA
RIGGDEFVVFMSGLTEKVAEIAVKRFRKSVERFNDEENRGYEIKFSVGIVVAKPSSDMSI
DSLLEEADKRMYQEKCASK
>A0A087B6W6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium catenulatum subsp. kashiwanohense JCM 15439 = DSM 21854|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKIQPDLIVLDVML
PDIDGFTVTRRIRQEGITTPVLYLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTQEQVEDDPIIRVADLEINEDSHDVSRAGQPIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGLTVEDENGEKRKVAPLIETKRGIGYMIRA
PKN
>A0A4U9HYE2|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MLLIDPARDGLLVDANLAALNFYGYTHEEMCSKHTWEINTLGRNVLPVMTEIARLPGGHK
PLNFIHRLADGTTRHVQTYAGPIEIYGDKLMLCIIHDITEQKRLEQELEHAALRDSLTGL
LNRRQFYHLTDHTSPNHLPAQQEFSLLLVDTDHFKRINDMFWAPKRRRGVDCSFAHAGNL
LS
>A0A7X1BJI0|diguanylate cyclase|EC 2.7.7.65|Citrobacter cronae|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSTNEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKAEYSPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A1C3JS86|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MSDDKSLNANPSYEHLVHIKDHSEVALYELIPDVVWFFDLDKHGWWWGNSAAVKFWGLSH
VDELINKDLSGDTQGAKDRTAQTFELAVQNGLTIDPWTTYPNGKPKTLYMRHRAVLLGPE
KHRGIIAFINEEVNLGETPENLLLVEAMRYTSVAVTSFDYDGAPVVENPEATEAYKHIPR
TNLPTGQSFFSARFVSPKEGEAILAQAIEHKGGEWTCHVNTAHGERIHNLDIRMTRHPLS
GDFLLLMSEYDVTPLHKALEVAQNAQEELRKLAHYDAVTGIPSLRYLMDQEQRLMAYSSK
QQLSLAILYIDLDGFKDVNDNCGHETGNRVLTQIAQRLSQASEGVGQAVRLGGDEFLIWL
SDSKDRAIATDMAEKLLGLIHQPIEVSKCCQITVSASIGVAFHHSEQQSLDDIIQAADHA
MYTIKHAGKCGVRVAPESV
>A0A5F1EIU2|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4702|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANTLDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSTSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMSSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A080LSI2|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MHELRVHQIELEMQNEELRQAQVALDTLRARYFDLYELAPAGYCSVSAKGLVVEANLGTA
TLLGVARGRLLGQPFSRFIRQEDADTFYLRRREILATGQPQTFELRLCRPEGQYFWVQVA
ANAAYAEQGGTFLYLVLVDISERKQAEEFGREQKESFRLIAENLDGFVAVLDREGRRVYN
SPSYTRLVGGRDIRGSSSFEEVHPEDRARVIQAFRETVATGIGQPLEYRFLRADGGVCLL
ESRSGVIRDAEGRSKQVVVVSHDITERRLAEARIHHLAFHDPLTQLANRLTLIDRLQQGM
AASKRSGHHGALLFLDLDNFKPVNDLYGHAAGDQLLIQVAARLSGCVRAVDTVARFGGDE
FVVLLSDLPAAPAEAFVQARQVAKKIRHGLAQPYRLTIRHARQADTGIEHQCSVSIGVAL
FMDHAASVDDLLKWADAAMYRAKEAGRNRIAFHA
>A0A379KAK5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MDQILSLLSETIPKAQTLEQLARPLLSLLNQFTGMESTYLTTIDTEQGVQRVEFARNAGA
MIIPEGLVVPWADTLCKRALEENRLYSDNVAECWGDSDAAKALGIKTYLSAPIRSQDGRV
LGTVCAASSAQVARPANVEPLLALLSGLLGYALERELLVAQLQAANSELGRLALTDPLTG
LANRRGIMRDLVQLFALAQRDSKYVLVAVIDLDGFKLINDCYGHQAGDQFLLGIATELKR
SLRASDMVGRIGGDEFIVIALGNALQRPAPAQELRDAAALMQARLSKATVGQYDLGNGLP
PYEYQGASVGVVAVMPDGTTAEEAIRLADNEMYQVKQQRKQQRS
>A0A379JRX0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MLRPLRSLILLLCLACVVPAWATSALPLLKLSAADLATPLSIEHSLLLEDPSGQLSASEV
LQRIAQEGRQVQGTARIGYTRSAWWLAVQLQTPPAERLQLIIGQTFLDDLEVWLFDGEQS
LGPLYSGAKRPFAERGEPYPQFLLNLPRLGDGPHSLLLRVQSHSAINLPLQVVGAEQGQQ
LIAYSWLQSGLLIGALLALALFYLVKFSTLREAQLAYLSLTSLCVALYNTSLYNIAGLLW
PQWTLLPKLLINLPTAGMMIFSSLFIASALGLQLGRLRWLRDALFGATLLVCIGGVFIDH
PHAYQTLNLLTLATGLYQLLLMILGVYQRRPYAPGYLLCWSAALVLMLLVPLSRAGLIPL
PAGFYALYAYLPALSMLLFGALLDKQLERVRRVLLSSQAQAIDNLEQYQALFRHSGEGIF
RCHRDGQLLDANPSLARLLGSETLPDDLSQLSLQSLVGETQWRWLLLQLDVQAGAVSCEC
QLYDLEQRPRWVYLSLHLRPHQEFIEGIVVDLSERRALEERLQQLAAHDALTGLLNRREL
ERLLSETLSGAAKRRFSHLLLLGLDRFKQVNDLCGHSAGDQLLRQLATQLAHQLPRHAEL
ARVGGDEFAILLREVDDEAALSQAEQLRRAVEQFVFTWQGRPFRLHTSIGLLALGSGVRD
WETALTWASSASQLAKHQGRNRVCQFNPEDGALLSDINANCNGLPACARPANAVISSCSS
NPYKRCRVPPPACTTKCCCATAIRRAASGSARHNFSMQRRVMTFSAPSTAGSSSICAPGW
PPTRGTWRNWLRSTSTSAPTLCSIPTSTVCCRMSCSSTAYRPENSASK
>A0A7I0L0X4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIELLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A655UR50|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MKVLPRVLLGLVAXXXXXXLYWQFGSAKRVLIEPQHYAYFTTNDQTAGGTSTSALSLNGN
TAKVDCELNASRYAWPYCGISIHLNPDPQRGLDLSDIHTIRLNVDLQGPAAEPAAMRLYL
RNFNPIYSQLDDEYTHKYNGLEFVPGVGKGVIDIPIRSLQVMTWWLVDNRIAIEHSAPEF
SNVNKIEFATGSASPLGQYQLTLHQVELIGDYVAGEKLFLAMLIMWAVAGAWLSALEIRR
NRREVLRARMRQEHLQRLNHSLHEQNIKFVEMAHRDALTGAINRHGIRDWLQDQARLVRW
QLNHVSVLFIDIDYFKQVNDVYGHSLGDDLLREFALVISREIRESDKLVRWGGEEFVVFC
AQTTLEQAIELAERLRAKIADHSWIHGGAITCSIGIAQMGDERITETVSRADEALYRAKR
LGRNRIEVHYGLMAKSSDGEKG
>A0A655S679|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLYWQFGSAKRVLIEPQHYAYFTTNDQTAGGTSTSALSLNGNTAKVDCELNASRYAWPYC
GISIHLNPDPQRGLDLSDIHTIRLNVDLQGPAAEPAAMRLYLRNFNPIYSQLDDEYTHKY
NGLEFVPGVGKGVIDIPIRSLQVMTWWLVDNRIAIEHSAPEFSNVNKIEFATGSASPLGQ
YQLTLHQVELIGDYVAGEKLFLAMLIMWAVAGAWLSALEIRRNRREVLRARMRQEHLQRL
NHSLHEQNIKFVEMAHRDALTGAINRHGIRDWLQDQARLVRWQLNHVSVLFIDIDYFKQV
NDVYGHSLGDDLLREFALVISREIRESDKLVRWGGEEFVVFCAQTTLEQAIELAERLRAK
IADHSWIHGGAITCSIGIAQMGDERITETVSRADEALYRAKRLGRNRIEVHYGLMAKSSD
GEKG
>A0A655YM05|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTHTLNRNQFELELAKALKETDSQLRTHAMLYLDLDQLKVLNDTAGHDAGDGAIQFCASM
LEDVLPFKATLARMGGDEFSVLLRDCTERDAVLVAQSIIHALSEVAFVWEHIRFNLTCSI
GIRMIDHTATSPQMVHAQADTACHAAKEEGRNRFNLYRQDDEDLRRRQLEMESVNLVHDA
LANERIELFXXXXXXXXXXXXXXXAQSTRCVASFRSLSAN
>A0A655VAK8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNDKVLESVIEITEQKNSLALSYSILATLSELLPLSTATLFHHLGRSTLMVARLMITKNA
AGKKEYQWQYDQVCADNGYQHSQSEMAFSQQANGQYQCFCPIPVEEHFSAELCLILNKDP
EPYRMLINGFAKIYRNYTVILHESERDKLTGLLNRRTLEDRLRHTFAINPSTEENHKLWI
AMLDIDHFKAINDHFGHMIGDEILLMFAQQMQHYFGPSSQLFRFGGEEFVIIFSSGNEPQ
IKQQLDDFRQQIRRHNFPRIGELSFSAGFCSLRPGDYLPTILDHADKALYYAKEHGRNQV
HCYEQLCENGKIASAQRPFSDDVELF
>A0A655YWN0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSDTLSDTSSFANVIDKSFKDLERVEQDNLSIAEVMTVIRRLVSDSKDIRHSTNFLNNQL
NAATLEISRLKEQLAKVQKDALFDSLSGLYNRRAFDSDMFTLIHAGQQVSLIMLDIDHFK
ALNDNYGHLFGDQIIRAIAKRLQSLCRDGVTAYRYGGEEFALIAPHKSLRIARQFAESVR
RSIEKLTVKDRRSGQSVGSITASFGVVEKIEGDSLESLIGRADGLLYEAKNLGRNRVMPL
>A0A655RTT7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNDKVLESVIEITEQKNSLALSYSILATLSELLPLSTATLFHHLGRSTLMVARLMITKNA
AGKKEYQWQYDQVCADNGYQHSQSEMAFSQQVNGQYQCFCPIPIEEHFSAELCLILNKDP
EPYRMLINGFAKIYRNYTVILHESERDKLTGLLNRRTLEDRLRHTFAINPSTEENHKLWI
AMLDIDHFKAINDHFGHMIGDEILLMFAQQMQHYFGPSSQLFRFGGEEFVIIFSSGNEPQ
IKQQLDGFRQQIRRHNFPRIGELSFSAGFCSLRPGDYLPTILDHADKALYYAKEHGTKSG
ALL
>A0A655X5Y4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDTDNRWRIALRSIRGELIIIGMIAVSIVLINTPKLLFEDKIHAYEKEQLQLTVELQKTR
IDYASLILEHLETHSLTPQLQEFFNLYHGNLCVLDENSPQQCPLSIIDAVQSTTSASDFV
ASTSVNITFAEGSILFFQVQGKQIRVLWFNHASFWPAPQKNISLVLVRGNHIQFLDNPIA
HYNALLNYTILRHRDDYGTLQFESMELSFLRWHLGEYQLISVFNDKVRLFNLIYWVMSAS
LTQLLTLTWFLTRLNLQKVAAQRHVYIDNLTRLNNRHFLNKISTKFIEHPHSIAAMIDID
HFKKINDQYGHITGDRILQAVASCLRKNVRDGDTIIRFGGEEFLLLFQANSNKEAWHMLD
RLRQRVKDDHSLYGTTISIGFTFIDGSFPAAISRADTALYQAKEAGRNQVVADSEKENDS
AADLPIQC
>A0A7Z1D3U0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLIVSLNNENADISSLRERIQQQICGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7W2Z621|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-01064|TrEMBL
MDTYLQTVKDEWVQLINETEPHIHQVTAQLASDHATALIAEFYRVVLADPIVAEFLTTEQ
VERQLQEALRRWLVEVLSCQVGQVEEQIRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PIINATPHPSDVKLSVYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLTWEMTLLYKVMLDSSIGNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDEAFNEVRQADDALHDRSRQVKFLRQVRNTLSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREITHATRAGTPLSALLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADALRIAERIRKRVEKIKVSSPTGETISLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKMQ
>A0A656BSN1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFLPIASTLVSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGM
WVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAP
LEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNE
FDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSG
>A0A8B4CGZ9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPSYTTQWTEIPI
ASF
>A0A8B3KH63|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A200LFN7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A9HLL2|diguanylate cyclase|EC 2.7.7.65|Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5)|TrEMBL
MSVAQVAVDAELRRAFTNVPDATRLLVHDVVERLTPALVAAFYDHFTSHPEGQTYLTDPE
TTERLRGTLMVWMAELFSAAPQHPQRMADSQRHIGRFHARSSIPIHLVSEGVSLVQRTII
HALGHENLTHEELTDAVLYVTNVLTAATGVMTFTYWRQRERAASNDVAYRLFALNQDLSR
EGEGQKAALLGWSYNVLRSLYVAKTPEDLQTMGLARSEFGLWVTYKVGLLFEGTDISALL
TGQIAKVDNELLPAILEDMAAERDISPALAALHAGVTEILSSLEVLFHASRSSNDVEDPL
TRVLNRRFLPSIISYELRVAHQTGRPMSVLFLDIDHFKHINDTFGHAAGDSVLQAIARVL
EEASRLSDVIFRYGGEEFLVLMGDTDTEQMLIGAERLRQKIENTPIRLPDGNLHQITVSI
GAAQYAGHPDYEELLRAADAALYRAKRNGRNRIEVADAPHHTPAPSLEGAS
>A0A840RJ56|diguanylate cyclase|EC 2.7.7.65|Silvimonas terrae|TrEMBL
MDSILLKLSDSVSGAQTLEELTRPLLEMLHAVTGLESTYLTSIDLDQGLQHILYSRNAST
TFAIPEGLTVEWNDTLCKRALDENRGFTNEVDDCWGDSDAARALGIQTYLSTPIFTGTGN
LYGTLCAASATRRDVSVDTRKIIDLFARLIAQHVERESLLTRLREANIELSAMALTDPLT
SLPNRRALLDELGRMFAVAQRETRSVLIAFLDLDGFKQVNDTWGHEAGDVLLQTIARQLA
QQRRAGDFIARVGGDEFVAVGVGPQQGESASDAAQAFGLRLFEKTRATVAAGAAQFDYAG
ASVGAIAIDPAAATVSEALSQADSAMYKVKQHRARRAAC
>A0A0E1CBY6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A806TEC7|diguanylate cyclase|EC 2.7.7.65|Priestia megaterium Q3|TrEMBL
MSFLLSLLPFSFLKKFRFPSGREVNEDKMFDKTNAEMLQQRVKLVSLALVISYPLYIYIG
FSLLQHAGTSQFRHTLIGIHFTSFALSSLYLFFYYFSKRKERFANYLSTMVYGYIFYYVF
AAALSTINSQLFTGRVDVYMMLLISTAVLCPMKLKHLCIIFIPNHLFLLYGLSRYVPDSF
SLISKQINTTAAVAIALLISYILYTYRHKEYMNHLQLKESEHNFFTLFKINPYPLLLTRL
SDHKVLLINNKAIHFYNLASQDLDQLDGFIIYPTDEDREEILKRLQQEKHVKNYILEARE
HGDSKWVMINYELLEYQSESCILAGITDITDLKAVEHELNLHASTDMLTGILNRRSGMEK
LQLELLRAKTNDTSFVLCFIDINSLKLVNDQYGHREGDWLIKTIAESISGYISKDDTLFR
YGGDEFLLIAPEQTEEYVHELWQNINNQLEDKKKECKKPYALSASYGFIICAPSDDTNLD
TLIQKADAAMYKQKHTRVSSIFK
>A0A822WD98|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MQKAKAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFM
AGVTVFVLHGGLFLFNYYRPLPSKYLLKWLISVTAIYGALWGIAGTVLIPQNDLLNQMIV
IIIIIGIASGGLHILQPSFLASLLFFTLTIIPLCVWFFQQNTLNYWFLGTALLIYFCFLS
IISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
WLKVNQSLCQIVGYSEEELLETNFQSITYPEDLELDLGYVRQLLEGDIRFYHMEKRYIHK
NGSIIWILLSASLIRDPENKPLYFISQIQNIDAQKRAEQELQHIAYHDILTGLGNRKLLE
LSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGDLLLVEIGKRLQTILRSTDLI
VRHGGDEFIIALTELSNVNQVIEIANKILIAISKPITIKRYGISITGSIGISIYPYDGHD
SDTLIRKADEALYRVKIGGKNNFQLFNTALHK
>A0A1V4I7H5|diguanylate cyclase|EC 2.7.7.65|[Clostridium] thermoalcaliphilum|TrEMBL
MKIRMKMSLLAIVIALILTHSVYAFEFDYSEIFENHGLVRLIIDVETGSILKVNKAAEHF
YGYTKDELVSMNIKEINTLTPEETEREWNAAANEKRNHFRFRHRLSNGEIRDVEVYSYPF
IHEGKEYLYSIVVDKTDEVALAKNLEKNRLITTFLVALIIVLLLLGSILLYISKEKYKKL
AVYDYLTGAYSRIYLDEWKKKTLSKRRCEIPKICVVLLDINRFKYINDTFGHMIGDKILT
IVADTLKCCIREDDLVIRYGGDEFLLVLEKVTQDQCKKIMNRVESELLSCKTFEFSISIS
YGIHEIKDDMELFDAIKIADEKMYEMKKSASEDN
>A0A1V4I645|diguanylate cyclase|EC 2.7.7.65|[Clostridium] thermoalcaliphilum|TrEMBL
MYNIAILILLSIVFILYSKNKRLSYSIKKLNQIKNIMYNVNDIIYNADSIDDMYKSVLEH
LIDLIDDASKGSILVYNSEQNYMEFKSCVGYDLDKLKNINLQVEELFLYKENGLKKASII
RNPEKYDELNMSIHNYNKFKQIRALDIKSTISIPLYIDSSLFGIVNIDSCISYTSFSDED
LKLCVHIKNELEMALKNIIYMNKLKEYANFDSLTGIMNRRYFYEKFKDIDEKVVYTLVYI
DLNKFKYINDTYGHLEGDEILKKFCFIVSKNIRSDDLFARIGGDEFVILFKNMSEKNGKS
KIDDIRKELKHIIDFSVGIKEFRYNDKMSLDELLRIVDTQMYIEKKHRVQ
>A0A0M2WEM1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MSSKLPSSPASAPAGATNATAGAMNPADIAREAFRRLATRRIAPTPSAYRDIYNEIAGIS
EPAETPAAPGAVLAASAPTESGAENVLTQFAAKMSESAGELGDFGKRFQRALKARDWDSY
ARTLAQLAEKQVKKGGGIELPPLPDGEQTRTLRELLSRTLGFAVATLLTGTPALVEEAES
LGAAIKQAHTEEALNEAALRLKQLCYQIELKSGDTAEQQELLLRLFKLLLDNVSQLLDDD
SWLRGQVDAVQNLIAGPLDQRALEDATRSLKEVIYKQSQLKHSLSDVKLTVKNMMMTFID
RLGQVAASTGDFHEKIGGYSEKISQAENISELNSVLDEVLRETRMVQNEALRARDKMVLA
RQEVQDAEQRIHTLEAKLQHMSELVREDQLTGSLNRRGLDDVFERETARSDRRGTPLCIA
MLDLDDFKRLNDTYGHLAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILLPETTVEAA
SSTMTRLQRELTRHFFLHDNEKVLITFSAGVALRLPNEDQAELVKRADRAMYQAKQTGKN
RVVVAD
>A0A0M2WWY1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
METLDPRTIMLMTTLMCGAMSIVMFSVYRSFRREVHGLGHWAAGLLLLVCASLLFGTREV
LPPALSMLAANAALVAGIGLSMLGTETFFGLAPSRRAYLLILGLAIAGNSWWLLARPDFS
ARVAVFSLLVFLFYARQVQLVWRHGERHFSSFFFGALMLMQAVVVLVRGVSALLHGGASV
NLTVAGTPAGIYLAVANFMALLLTVGFMTVATRRLQQILERRSTHDPLTQVLNRRGFGDA
YARELGNLRRRRLPLTLLSIDLDYFKLINDSYGHAVGDQVLAHVATVIKGALRESDCVAR
FGGEEFVVLMPDMPAHNALGVAERIRALLHEPSRLPPCTVSIGVACQASVVEGLEQLLSR
ADAALYLAKERGRDRIEFDACVFTEDRTMSAAGSGTGR
>A0A1V4I5Y4|diguanylate cyclase|EC 2.7.7.65|[Clostridium] thermoalcaliphilum|TrEMBL
MNIDRKHIFKVILTGLIIGISFRLIAFYITLPISSEYLYNTPFTIVNLLMGGLVGVAFAT
LFYQYKELKNNNELLSVCASTDDMTGLYNRRTGLSFLEEQLKLLQEKDIKLSVFFIDINN
LKIVNDMYGHKEGDELIIIVGNILKESLRRDDFVCRIGGDEFLVVLPYCSLNQSEIVWNR
ICENINQYNSKKIKPYNLSLSHGAHECKKGETMEEILSFADKKMYEEKNKYRNLSLT
>A0A0S4L8D6|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrificans|TrEMBL
MSILIVDDSADDRLLLQAILSAAGYENILTADSAAAAFKHLGLDGGKQSGGRVDLILMDI
LMPQMNGIEACRQIKAADRFRDTPIIMVTVKTDPVDLQLAFAAGAMDYVAKPVNKVELLT
RVRSVLRLVHEIDRRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAVRESTPVSLIMFDIDRFKTYNDAKGHTAGDECLKQVASAISSSVNRPGDLVARYG
GDEFVTVLPGTGIDGTAQVAESLRRRIESLGMKHTDGELVTISVGYACMVPSRNSSPTDL
IRAADQALYQAKQEGRNRTKSASILSLVQDSQDD
>A0A6P1PY33|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MLINSLFRRLRSERHPHAIVHLCFILVLFFSTFLTWREVLVLKETYETERQIKLSAVADR
LERQFQFSLDSLLFYRRMLQYALANPRDTNDSRYAIRLFNELRLQPSWSLNVNTQRNMPL
NGVSDLWLRSLALLDRSNGYRLQNELRAALEFSFILQFTEPEKDFEQRLWYLSRAGFFIS
SVPPVDSQQILSSYYTMIHRAYFTDMMPERNPTRRLRWTASYPDSLNGGVVVTVSVPVDD
DNYWYGVLAMDFASDKIYTYLRQAIPVGGQDTVLLLDRARKPLAASGSIPLRDAEALFDA
AEREQLRQQMAQGSRGQLRIGSRFVSWTRMHNFDGLLLSVQSLKEGIQGETGRVTLVLLI
IWLFFTLMLLLAWLTVERLVDKLLKLQRNLYQRASYDPLTQLLNRGTFFEQANPLCALCE
LHQQPLALIQLDIDHFKQVNDTWGHHIGDRALQHTATVILSQLRASDLCGRIGGEEFCIV
LPETDGQEASKVAERIRSTLAAAKLEIDEKHSLLITASFGVVSSQEQGSWDIEKLQPVAD
RRLYMAKQRGRNQICWLD
>A0A3R1AGJ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kidderminster|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F9Z1C2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Minnesota|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A653KNG4|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MPCLFVGVTFVGKVTDGGFTSSADSFVAVYAIYYFFRIMVMVDYFQGSLFHFSERAQYLA
ALLNSLEDQIAVIDRAGVIHYTNLAWNRFAEQNGMPKGYDWLGINYLRVFDSAVEPLVLM
AAEGIRRVLCGEQDHFHLEYPCHSPDIQRWFMMRVSPVLGVDVEFYTITHINITERKLLE
LDVTHLSQHDPLTGLANRRLFNSFLHNEWRRSMRERTPISFIMLDLDNFKACNDHFGHQV
GDDLLRQAGHLLNAFCQRPADLPSRFGGDEFAVVLGNTGKEAALRMGEAIRLGIKELSMN
ELGDARLSASIGIATQLPERVLISEDELLAAADMALYTAKKEGKNRCHSVACPSLPNP
>A0A7W6T8E4|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. SBR1B|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDID
GFEVCRRLKSDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRPSSYEPLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQASTRGKPLALMILDIDFFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>A0A4R3Z3U7|diguanylate cyclase|EC 2.7.7.65|Biostraticola tofi|TrEMBL
MSNSKEDYDRLVAGEWQQLITLTSAAAHQVVARIGREDISLMVDDFYQYMLSDKDAQIFL
SSQQVKQRLHATLCQWIQQVISSADAVLPDLIAAQRRVGEVHARIGIPIDLVARGIRRLK
ERLYQRLQQDMLDSKLCYDAMRFCSLTLDIAIEVMTTAYSRSFASAAKHKENYRLYTLLD
NASLERERQLASLLNWENRFIYAIATGLPLEDVEPLQRAEFGLWFQHKGKHLFEQVAEIS
QIDSVMAETDTFIIGFQANGTADMQQRNLLLRTVRNNIRIISTLVSGLFDELSRYENGKD
PLTQLLNRRFVPTILRREIGLAIRSDAPFVVVMVDIDYFKRINDTYGHDIGDAALKSVAA
ILAENVRSSDYVFRFGGEEFMLLFVETTQSQALMLIERIRTLVCATPIRTGVSQPINLTI
SAGLCAFDGHPDYERLIKKADSALYYAKQNGRNRIEIHKDQPQ
>A0A5E4SCP7|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MRIRHWLYAACLSAGVLVACWVAADRTATSLVGDKLAQSVDAGQMVADRVADGMVHAINT
DLAMVRAIPATFAEVDLLRDVLRASQDGVPSPDTVARANEFLRGAQGYFGVDRIWVIDTR
GVCVAASNFRDAPSPVGRSVAGMPYVTRALLGGRYEGYAAGWEPRSPGLYFSAPVYRDGE
LIGVVMTKIGLLRLRHWVGSGESFITDGNGVVIMSHEPRFENRFVLDGKLGSLTESERLA
LYQRQAFAGMPISPFRRAPGRANAWVPQSLLERMSAFDDQSRPFVIASRPSSSNDLIVYA
VEGVDAWEALTRQHAKDLALCFLLYLGGAVILALGGWIYWRERVQHRQVRQSNEALRAAN
HQLAFEASYDELTGSLTRRYFFHRFEQLLEAAQRKNEPMSLIVADLDHFKSINDTYGHSI
GDQVLCRFVLVCSSMLRGDDLIGRIGGEEFAILLPGASERDALRVADRIRERCKRESVEG
SEPPLRFSSSFGITEWQDEDSPMNMVERADMALYRAKRAGRDRCWVF
>A0A5E4UPU2|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MPDAMPAVPPQAPSRAETDLAQTSPSNLAHGATGAASDDAMMFDLAPVSLWLEDFSGVKR
MFDTWRAQGVTDLRTHFKSDPAHVSACSQRIRVIKVNQRTLNMFNAPSLDTLVANLPRVF
RDDMLKTHIEELCQLWDGRTQFTSKTVNYTLDGRRLDVLLNGSVLPGHEDTLARVLISLE
DVTELEHARERVTMGEQYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVH
PEFVERCMTEIHVLDVNRHTLAMFVAPDKATLLARLPDVFRDDMRHNFREQLIDLWENKL
FQQREVINYALDGNEINVHLQFAVLPGHEARWDLVLVALTDITARKKAESYLEFLGKHDV
LTKLRNRSFYVDELNRLERKGPYPVTVVVADLNGLKTVNDQLGHAAGDGMLRRAGEVLGK
AVVAPQIAARIGGDEFALLLPSTDATGGAAVMESIRQLVELNNSFYPGTPLSFSMGMATC
EAGERLEATVQRADLLMYEEKRNHYAGSVNERRVLDALPSGSGSVATSAAPGASGTPGMA
GRGDA
>A0A1V5WDU1|diguanylate cyclase|EC 2.7.7.65|Chloroflexi bacterium ADurb.Bin222|TrEMBL
MLTAMQTLFYPLALGVATTALIALSWHYWRDVKRQGATWLVTLLAFWALCEMLRLISADV
TLNTILLRLSFVSRSLLPAAWVLTTREFAHKPPLSRRRCWLLLLIPFLTQLVLWIPPLRP
LFWRDEIAAAQTLWWATPTTLYGPWFWIHTAYSYAVAIPAALPLLEIARRSTQRYREQAR
FALLGALILGCASALVVFKGPEPRNDLPAEVLTAGMALLCAWGLYHYQWVGRSRSFDKIY
DNIHEATVVLDTSQRVADMNQIACRLLKAPLERTIGESAERIFLPWTLWAPYLASAEAVH
AELLMDQEHGAQWLEVHTHPLRDTNGKLTATVVTLQDISQRKWMEQALEARQRELAELNA
LSRAIASSLALDEVLEGIINAVMRLFPQAADASVQLLDYAQSPPIRTCSYATERREDQPV
LHFELGQGLAGVAAAEKITLNIPDVLEDPRYLWQKGFPEYRSMLVTPLLFGAEVLGTLSV
AASSPHAFGPNDARLLEDLARFASIAVQNANLYEQAQAEIAERQRAVAEMRQNELLYRAL
FEQTNDAIFFINLKGDRYITANQRATTMLGYTLEELLTHHPNDIILPEEQDDAQARLQHL
LAGETVPIYERRFRRKDGRILTTEISIVLIRDAEGAPLHFQSAVRDVTQRKANEEALKQS
EEKHRLLLDSIQSPVLALDHEMHILYCNTAYASFVGKPTETLVGRTLSELFPRFAHSRTY
NAYQRCLATGKPQTIEGWSEEQYFKARIYPTPWGLLAIADNITEQKRTQDTLQKYAERLQ
ILHEIDRAILEARSPEAIAHSTIQQIRKLIPCERSLIIECDPAGHNTLLALDDDAGRLAP
AEDVIAIEERSQFAQGQPLAIADLESVTPRLPVLERLYANGVRTCLWEPLLALEQPIGLL
CLEATRPHAFQNEDVEIVGEVAASLAVAIRQARPTNRPARTPPLKPPSLTKSTIGSRTTW
RPSSA
>G8SK44|diguanylate cyclase|EC 2.7.7.65|Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)|TrEMBL
MAFAIAAFHSAEGRQAVQALLARSGHTVAHFRTGAAAVAGALAKRPDIMIADTRLADMSP
VQLGDALRARPETAGIPLILCGSVDAESKRMAQDLHQRVFRALLTPRSLQSVISAALAVR
GGSPDAAVAPRSAGDTPTAAAPATGEQWRVLLVEDDDSIADPLVEGLARYGITADRVATG
VAALAAPPATMVLLDLGLPDIDGIDVFQQLRHTTDVPVIMLTARGDEADRVRGLELGADD
YLGKPFSIRELVARMRAVNRRSTTAAANQGRITAPTGLR
>A0A379H5J1|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MPKQGMNTVAHAESTIRTRKKYYLLFKVMIILVFITLIISFAIAIINFHAYSERQVNGYK
HLLFTLGNSYLYEHVRGSENQLQALESRLNKQEIAAGGQVFTDVWPIVHKIKLEEDHHIF
FYNAMSGRVDAYPLWVQPEHYDATIRPWYQLIEQHTYLPQWIGPYVEASGATRVLTLGKA
ITSDSGNTLGALMVDMPLSSIDKLLSRMVADDSITLFVRHDGSENTRDIISVINPRLMPK
VLPTAENTYSSLQGLKQGIFLRQPLSYVPWEIGIYVPVDNFRQAFMHEFVMLVIPISLIV
LLSALGLRALLKIFRQELGLVEQEFTLLSVNQTSQLDKEAHNAWFVDRSISVLKEHYKTY
HLSLRLDPLTKIFNRRAFDEDMALAVQHNTHFVLVLIDVDRFKLINDTWGHAFGDVVLRR
VSGVLAEELGVAHVYRIGGDEFAAILPLQGRALTSVLEQLQTVIRALRWRENSCRVTLSM
GVANGPQPAAVLFEQADQALYKSKGVGRNCWHYFTRQDIREDIEESVDG
>A0A5H7ILN4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mapo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8I0SZM1|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAAVGAMLLRKLLPWYNPLQN
LNDWIRLAFGSAVIPPLLGGILVWMLSPHETPMKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTLTVTLILSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLNNDL
EQLTMLVSGDINSYSMEKRYYTRAGEVVWALLAVSLVRHPDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSVWYDCVI
PEDREYAEKVVRDSLATRLPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDMKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIINAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQELAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSAAGLISTTLI
DELLAQLEQSALPGRLLHLIVPAEALLLHPQESTAAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSMADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIADAQPLDLLLNTSYFAIN
>G8S0W7|diguanylate cyclase|EC 2.7.7.65|Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)|TrEMBL
MSIDTAGIADAAIEAALVVLEETPRQDLDPRPTLAEAGRLGRAALRGGRCDLGMRARLLE
ADAVSRTGDVATGARIFQEVNRWAVEHRHPRLLALSHIRLSLFYSHLGDTVVALDHAIQA
QQALAAMGAEASPMLRLRGTVQLANVHGDNGDHASARARYAEAERMSAGQIAAGRVDARV
RITVLNNLAYTEYEVGDIDAAEAAADRLLAAAAFHGLDLDHSGVDTVARIRMNAGRHAEA
IALLEPLVAVETDDAFSELNTTASLLLTLAETYRRCGDYPAAGAALDRCQTLVDQRGLRS
VGIELLRERSEVLAASGRHVEAFEVHKRFHAAAMAAQSAERDARARTLHALHQLDEATGL
REMALRDPLTGLYNRRYVDAELPLLLHRAAENGEPLAVAVVDLDHFKQINDQGSHEAGDR
VLREMATLLTAAAGAGGSFTARLGGEEFLLVLPGAGAAEAAERMTLLCETVRRFDWRPIT
GDLPVTASIGIAVAPLGRAGSAELLHEADSRLYEAKRSGRDRVAA
>A0A8I0MKK8|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MDKDLSPTPRPTFKRALRRINITSVIVTMTLIWLLLCAASVLTLKQYAQRNLELTAATMT
HSLEAALVFTDDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNAQENDDKLGDFIS
HWLFPLPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRTERSIK
>A0A381G7I1|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MLSEKYVIHYAISLSGFAMHDTQAGLLILMAPFFFVLIMMGLKSWLNESDLKVYIDSLTG
CFNRKILDIIKRRDLSDSSVVLVDCNKFKAINDTWGHVAGDRALQIIANRMLSNTRTSDD
LVIRTGGR
>A0A5H7IG04|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mapo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4P7J3J0|diguanylate cyclase|EC 2.7.7.65|Citrobacter tructae|TrEMBL
MMRQTAEIDSILIDLNHSIDAHYKWLVKMFRCVVSSDITQADISGNNSHYACQFGQWLNQ
RLVQDDEDYNYVSKINAVHEEMHLLGKELLLAIVEDRSQSSHFDRFQDALLAFTSAVMDY
KIYLLNIRSNIDALTGLPGRRMLDESFDQQLLDTEPLNLYLLLLDIDRFKLVNDTYGHLV
GDLVLRSLASNLLLWTRYDEVAYRYGGEEFIILIRTKSDEQASRAGLRLCHLIEQKKIPY
PEGEIGITVTAGITRVHQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQIMRVGANN
QITALVRA
>A0A0H2VT98|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A522LZ62|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium|TrEMBL
MFNASPEELQAALQQLEQAIYNHDAWYKELNRTLICQLPHDRRDVADDAHRQCRFGQWYY
NLAPQKLHDNAAFAAMEVEHERMHRLATRLLAASETRKVIRSHDYDEFSNALDRLRLQIY
TLKREIEDTLYNRDPLTGVESRVGMLTKLREQLELVKRRIQHCCIAIMDLDDFKVVNDTH
GHLAGDLVLAAFARYVMEHVRTYDKVFRYGGEEFLVCLPGTDLKTGHALIERLREGLAAT
AVDHGGKAILTTVSFGVTLLDPDISVEESIGRADKALYAAKAAGRNCSRIWDPSM
>A0A3T2UYW4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A380AY21|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAM
ASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDSATIIRHADTAMYTAKEGGRGQFC
VFTPEMNQRVFEYLWLDTNLRKALENDQLVIENHLAWRSAQSGSTSTLAVT
>A0A0D8I349|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MSSSESVRSRNTSWRTLKEWFDEPHDYEWISNQRSRRAIAPIFRGLLGVMTAILGSGAFF
KLIGPDAPTASAGKFLSVCMVIGSLIVMTCWFTLPFPGRRGLLAFGIFADLGIASAILLV
PDRDSALFGCIIFAISGTFATLFVSARWLMTHVIFATSITTLILVLAYQQGTVDPTTIAA
RATVLLGAVTIVPIFSHLTWRTLYRDARDSDRDPLTGLFNRRGLDAAVIDLFDSARVQEK
CLAFIVVDIDKFKMVNDLHGHSEGDQVIIRTANRLKTHIGDQGVVGRVGGEEYLAVISGC
HEEIGTLIDGITSAISDHSDLVPTTVSVGAVIMPAGSKAWTGGSSAISVASNVADSMMYQ
AKAAGGNSLRATEI
>A0A0D8HPU1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MNFGGDAGPRSLIRNQIEVSETRMRNGIAVLVPVFALVGVCAAFSDEGQNTAFRRIVAVL
VLVSTLPAAYLVSRIRFGIIWWNRDMGHHSVPRASTYFVLYADLGVTVVLATFANHELAL
YGTALFAVISVYVAHFVRWAETVVHMVFTSCVIAVFAILTWRQGYHDIAGILARAVTSVI
AVNATLVLLRSFSAGMLTSYRTQFANANRDPLTGLLNRRGFELWMQIAEEREPGRSGVLL
LDIDNFKAVNDGSGHDGGDTVLRLLSRRLERVVGVDAAVARTGGDEFAIAVRGDIAGLTR
LAEAIRGEVAVRSDDVPITVSIGVAQLASGAHGKLTGQEQIKEALSRADKAMYEAKSDGR
NRVVADVSAQ
>A0A381C3D6|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MHYMMMQAHHHSHVINYNIHKTMASLLIAIIGCTLGFGCFLFKKFRGKRYLLPALLFSST
IASMHYLGVAAIINAGHRHASITYVTLSLAVIFITSLIMLRLTHMMLVMTSKNDSYANFY
RLSATVTLCLGVAIMHFLGTSDLNMAPSFRALAAINQEVHIEKTIAMMLIVLIVMIFIIS
IFIWFVNFKEHLSNELLKRELIAKNLQLKKMTQHDALTQLPNRFYLQNHLHTLFKRQVEP
LHILFLDLDGFKRVNDVWGHAIGDELLVSISQTLRIVVSDEGFVARIGGDEFIIVVCQRE
KEAVIELAKKILASVSGVYTLSATTIDFLSASIGISIYPEHGRDIATLLKKADTAMYYIK
NKSKNNVIIYDDTEMILPT
>A0A3S4DW83|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MKLQNKLLRHVISAGVVVLTSSFLVYELIATHRDMSGYMRYIIEKGESTFLYDKYQNQLI
ISQFLRKLDTPPNQTEVEQVCNSVQHNGDVSGLNIAGYTYPQLHGTLSAAHADCGKWRGD
IPALQAFDRAVAKNDSWQPEVPATLKSEKRFRYYIDLVNKYIYFYAPVRIKSNPIQNWNF
LQDSKLGISQASLDGLEQGRSLISTVYVDAMTGKNILSFLTPVYFKDKLKGVVMVDVTAP
EIEALLYTRDRPLVWRYLDITLKDSDTGALIEVHHSKTHLLNYAHYTHQVAENLRITLSL
DVMYFLLSSWKLFLFYLLSTAALLHLVRVHFRLYNSVSKENISDTMTGLYNRKILTTMLE
SRLQRLTAQGVNVVTMALDCDGLKKINDTWGHNAGDEAIILLAQAISASIRSSDYGVRLG
GDEFFLILIDYPESEAENIPARIRQYLTIHDHQQRVDFSWGAEHLAPEQSLSEAMKAADA
RLYMNKKQKKSPDIRR
>A0A6N3B891|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MISVIITITLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAVAEVINVHKKRFAYWSWNPKDNNDTLGALVSRWLFPVPIAQPIMHNGSMIGE
IRLTARDSLISHFIWMSFAVLTGCILFATVVAIAITHSLHHGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSARINSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMVEFGDKRHQ
SYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALARENA
SVEALLEKADRNMYQVKNQRTKTIS
>A0A212K5P9|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfovibrio sp|TrEMBL
MPIAEQSTREKKGALCNCNRRMLAITAASLLFLLTIIWSATLWDIARSEKEVQSTVEITT
RTLARALSEHMLSTIKRLELAIKELDAAWTPDQNDIRTEAERLKKIIGDLALQISIVEPN
GLVAYSTLPHIAGISIADREHFSVHLTPPWREIHVGKPVLGRVSGKWTIQFSSPIVRQDK
LVGVIVISVEPDYFASFFRSLGLDVQDSIDVIRSDGTLLVRSTGDGLIYGHIISGTAYLK
ANSPISGNFRRPSQIDGIERIFGYYKLGQYGLTFVVGSAVGNAFAPFEQIRTATLCAAAL
VSALLVALAFLAYDSLRRRDEAEKQLELTGQVFDFTGEAICITDSETNILAVNESFCRLT
GFSQPEIIGKTPRVLASGRHGTEFYKHMWDQLFSNGWWEGEIWNKKKDGTFYLEWLNIKV
VRNLRGAITNYIGVFADIKKIAVTQRRIEFLATHDELTQLPNRAVFCDRLQKALDCYPPT
SCQFAVAFIDIDDFKIVNDSIGHAAGDSLLKEMALRLTTAAGADAVVSRFGGDEFTLLLE
NVDDAKAAATAQRIIESLRQPISVCGFEIYAGVSIGIAVYPQHGSDISTLLQNADIAMYH
AKGQGKNTFSFFNDELQIKAAIQLQIESGLPRAITENELVLHYQPQVELDSGRIIGLEAL
VRWQHPNDGLLFPGKFIPQAEKTRLIDKLGEWVADSAAAQIEQWRAAGLNPPKVSINISP
SQFLRGAALPMIERILNKYSIPPYLLAIELTESALMTDPKEARRALGKFRDMGLEISIDD
FGTGFSSLSSLRHYPINRLKIDQSFVRDLDEAPDACAITQTVIDLAKYLGIASIAEGIEN
EGQFTKIKMMGCNIGQGFFFAKALSVEELEKRGFVSTGPTIITRDQ
>A0A5E4Y3G8|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MSVAVLGSLFGTRVPGVRPWCVASAMLAVVAALLLTGTSDVIVAVSSSLLVVASLIGLHG
FRQFLNARSSYAWEYVVLGVILVMLIYWTFLSPHVDARSAMISGSIAYVRFSIGAAVLKY
RPQERPKYAYYFVAIAAMLGAVVHAVRSVAYGLGLAHEATFLQPTPLNVVFLGMATLTLP
CLSVGMVLLAHDRLADRMERLATFDDLTGLLARRAFITRAEAIARECAERKSTFSIAILD
IDNFKSINDRYGHAAGDLALAHVASLIARAVRTTDIVGRIGGEEFALLLPGETKENAGRL
IDRLRDVVATSGSCVSGRDVASTLSAGVDAFRDGDTLATVMARADAALYAAKAKGRNCVV
VAPAMESLPPGPLAQENGARFGGKTANG
>E3HEF0|diguanylate cyclase|EC 2.7.7.65|Achromobacter xylosoxidans (strain A8)|TrEMBL
MSSSSLGVPPIPDRHAGASDQACYLSASNEQAWIAVYQSVDAYTRGQVAAVVGDSLSELV
DAFYSTLLADAEAGPRLSHEIVSSRLHAGMTRWLKGLLCVRDQGDIAALMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIALRLRVSDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPGLQQITDAVAQLDGVVLPQLMRGEELGQAGAMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISIARRQRSEFSVLLLDIDHFK
AINDQHGHSGGDQVLRQFAEVLHQACRSSDFVFRYGGEEFLVVLVDAPREAALAAAEKLG
AEIRRHVFNIPEAGPLHITASIGVATFDGHPDYAYLIDRADQALYQAKQAGRDRAVAA
>A0A6N3M6B5|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYNADEIIGQSFELF
YTPEDLATQLPAKGLLHANQLGHYENQGWRVRKNGKRFWGHITLSALHDSDHNLQGFVQV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
MGYASNEIIGQHFGCFFLPEDIAAGLPEKLLKTSASASRVEREGWLVRKDMTRYWAVAII
TVIHDNSGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNQLVAINQCLAEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAISQLGQDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCQNKPATEVLERVVADIASIQFHWHGQSYSFTASLGAVSL
NRQTETAAQAMRQADIACYAAKHAGRNRLSLSL
>A0A1V4VUV1|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MAEMLRSGIEALQIPHASSSVSAFVTVSAGVASTVPLQAGSPEELLAAADKALYQAKQSG
RNRVVLGKL
>A0A446ZMZ5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter calcoaceticus|TrEMBL
MPYSLREFSFSSSLKFFLLFGFIITVCCFIGIASRPLSFLAFFWPANSVLLGLLIRFPST
RRPSTLLGAYIGYLISDLFQGTPFTLTLVLTTSNFIYVVTTLALYMFFNQHIKAAYRGYS
YLFLFGLCGIGSVAGALFAATFVPMFNTKFMLGSLWDEFGYWFTSELQNALLLLPIILNL
PQYSQVKHYFSRNHGLQAIDLLPFLAVIISIAASYYDSGPGSLLYPIAALIWCAIRYKPI
IVALITTFTSAYIIYHVSGHYLLLYPNEYLSNTISIRIGLIMMTIAPLTVSSISVLHSEL
IQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVHKENKTSAFFMLDVDHFKQVNDNYGHQ
IGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIADTTKESAFDLAEQIRIKISQQPIY
IYGKLPIFIQVSIGISLYSPSSHRVIENLFKEADDALYQAKRQGRNRVFISL
>A0A564SGP4|diguanylate cyclase|EC 2.7.7.65|Dorea formicigenerans|TrEMBL
MHILFEVLATILMIINVLYVIRVFFILKNSKNSDNLKKKNLNIVGDLYIALLILFVVGYV
CISLNNNGENSIQLNIMAQIMFWGAVFVFISVYVFRTLLKITKDQYIGELSDLQISLDTY
IKSIPGGVHHCVVEPELRVYYVSKGFTDITGYTMEEIDELYNGKYTDFVYEADRSTFVAA
IERLLRTMSETVVSYRIVSKRGDIIWVSDSMNIVKDSKGNRHIFAVVLDITDEKSSAETD
ALTGILNKGAFNFNVRECMKLHADEHIALFMIDLNYFKEVNDKYGHHSGDTILIKTVEYL
KAAFVDEDAIIGRVGGDEFMVLVKSVISEDAVMALKKKVQDNFRLRIDDIPDFPPVSGSV
GCIFAKCSDDFETVFRRADNAMYDEKDRAHALRK
>A0A1C3J988|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MESNQLFFRTIVNASYDIVDTTVNEAIKTYLKGITDTVASHVWHATPEQEIEQVSQIASE
LHIGQSGYIYLMSPQGVHLYHPFLQGKKRGHLTHIQKQLSIDSGMIEYFHANPHEISRRA
KVAYSMRLPSGNTLVATTYKEELMYLVDLEGLKDKLRNYAFGDSGYVYIIDLQGNLVLHP
DYEHKSLKALIGYSSELLIDRIATQPEGHFSYSISSDNGTTNKNVFYKFYPYLNWVISAG
ILEQELNRNHSLLFISLMALVVSLLSIIIVVVLYLRHRHLKILDVASLDYLTDLPSRRSF
IEQLKLKIAQRSPYPLTNVGVILLDIDHFKRVNDQYGHAQGDRVICEVAKSLKRFVNRRR
LIARYGGEEFILVTFDCDERELFELSEELRRSVEQLQGLVSPVTISAGCCHDRALTDIET
AIDKADKALYQAKERGRNNTQTYQKNEYRVAYM
>A0A485DH25|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MVVTDLDALNILSTPIWVVLPKNQEILFANKEARKIAGDIQLSRMRNGRFSAHAQQHLHA
YLPALAVDDHVIEIWTIQTEENAFPLSCRLSLTQLEPYGVVIIFEGLYISESVVTQPASS
KLMAKAYSRSEQSFYEQFFSTNTAPMLLIDPSKEGLIVDANQAATRFYGYSRDEMCRKHT
WEINSMGKDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEYAALKDPLTDLGNRRQFFPLVEHAHAQSQRYGQNFSLILLDVDHFK
NINDQLGHHKGDEVLIFLARTLESIIRECDIVFRWGGEEFTILLPSTNLKGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A518BM63|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla133|TrEMBL
MHETSTILVCDHRGAGILKALRPLAAAGFRIECSQSLKHSLERLNRARPTLMVVDMLSPE
GFHELGALDRAREEPQLVPMLVVRDSEHSAAWQRAVRALHAPAWDLVDREASAEEFRLRI
DRLLAESRLRHEVDDLRHRASHDDRTDLLRPQAFQSRLSEQFSAAQRHGLALTLALIDLD
NFGSVNKIHDHTVGDQLISEVGSVVRQSLRTEDIAGRLGGDEFAVLLPFTSPSDASGVVR
RLLTQIERLSGQISGRSGAPLSVTGSLGYATFDGSNVPTADELRRRAEQALRAAKTGGGN
RAIAWIEVPQTGAVDEGVAARSV
>A0A128F4S0|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MRQIFKWLFVTVLFLQSGAALAAYQVLAIHSYHPDFFWTESIVRGIEKGVEEQDIVVEHT
YLDTKRIQSPDYHEELKRLYLTRLEEHQYDAVLTTDNAALWLVNELAEEIGNVPVVFSGL
NSASLEPYQNINMLGGVEELINVPANVSLIKYLHPDTERVWLALDDAYSSRQYWQAISRQ
LDSAQDMGVEIRRMHKVSFEQLVEQSATLEEGDVILFVSFFKDANGDFMEHGDLLTKVTH
AATVPVYGANSFMLPYGIVGGIMVDGEHHGKVQAGLLIETLNSGEMPQIISDANQLIFEY
DAAKKRQIDIGQFPQATVNNQPPPFWQANRDAVLSSLAIMFIAMVIIGILTKHMNRQKQG
ERALAQSRALFKGVFDQSHQYIALLDYQGRVISANGAFQRLFPEYANRGFLPLWRWSEWL
SADRLKLHLESLIEGQASRFEVCLLSEQQNEVILDVALKALPDHSHADAQILFEARDISQ
RKLAEQKLQRSEVEYRMLYEQQPVMLLTIDQQSRIQSVNQCTTEWLGFSKRHMLGHKVTD
FYADGSLPPRSLLNGKDRERFGIRRREIRYRTSDGKERWIRESIRSTQVQSQLLLVGEDI
TENRRMEQQLRYQAQHDFLTGLLNRNYFEARLVDVLGTLTENGATHAMFYIDLDQFRVIN
DTVGHEAGDEALKQTAQVLRELLPIGATLARLGGDEFAVICYDCNEQDALDQGRKILDTL
SELDFYWKNTRLALGCSVGIRMLDKTAGTPQQVHAQADTACYAAKHDGRSRVHLYRPDDQ
ELRRHELEMSFVSKIHAALAEDRFEVYAQPIVSVTSRLKEKLYFEVLVRMRDPKGENVAP
GQFIPAAERYNMAHLIDKRVIEKTLGWFERYPEYVDSVGMVSINLSGRSMSDEGFIQFLI
EALKTSTIPSTSISLEITETAAIGNLSDAIELFKKLKQLGCTIALDDFGSGLSSFGYLKR
LPVDIIKIDGQFVRDIAEDETDYVMVRAIHQLATQMGKKTVAEFVENDAILMRLRSLGVD
YAQGYYFSVPKPMEQLILEAAASEKEAVL
>A0A8E3X9H5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter towneri|TrEMBL
MYQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSSSEQVQTITEF
IYQVDELIQKIGQCESQAQAIEMIQSIRAKNREILHLVDQIFQVSEYINSGNDALTQLLN
RRYLNTIVSREINFSRKNNSPLTLLAIDADHFKSINDRYGHAAGDDALQFLADVILQYAK
GSDYAFRIGGEEFLLLQIDTTIDRALVVAENIRKRVEKATLKTSTGEEFNFTISIGVHEY
DGHPDYQRFFEEVDKALYMAKNNGRNNVSVG
>A0A8F9G391|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MTDHEHSKSSLEAAFLRHDESLAPPNRVFGDDDSAVYRTLLESTKAIPWKIDWATMEFAY
IGPQIEALLGWAPSTWQTVNDWAERMHPDDREAVVNFCVAQSKAGTDHEADYRALTRDGG
YVWLRDVVHVVRNDKGDVEALIGFMFDISERKRTEEKLAQLQRELEHLSFHDSLTGTGNR
RRFDDVMDRTWTAAQESGRALSVIMIDIDFFKSYNDYYGHLQGDECLKRVARVLSKAAGP
DHFLGRFGGEEFVLVLANTEADTAVKIAEHCRALIADEAIAHVRSPHQQRVTASFGVGTI
VPHARTDKTTFINLIDAQLYHAKENGRNRIAAVDRAGMQGEAFKSHSR
>A0A8F9XJ17|diguanylate cyclase|EC 2.7.7.65|Leucobacter luti|TrEMBL
MRTTTVFGTWARGAQSELSIATGSFMLAGGVFATANATLLRASAAPRPDLVIIALLCFIA
GITIFIAGRRFTGFAAGALMIGVLCVVVPSVWFTPTPLRAINLGLLFLPFFIYLVWFLPM
WFARVLGYTWIGLYAGLVLLRFGGEITTVLLTLAVTGAVLGELIGHFKAKLERASITDPL
CDVWNKRGFERLLGKLIPTAQRAGQPLSMLYLDLDGFKAVNDEHGHAAGDLVLQRFAAEL
QQHTRPQDVFARFGGDEFALLLVGSDAEGATRTGARLQRKVPDPRWSFGVSEWRAGESPG
DFISRADLLMLTGKRGRKAEPVSGAG
>A0A564FZQ1|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MSQGHHADRDRSFALAQRAQELMRDYGPSATPRAYAVWYTYVAGDEPLLNDAIKRLITQN
RGLTEHDTDELHDQYLGGRRLASVAGETSATMLAEIETVMEMLDLSVGSAAQYGESLRML
SQDLALTTLNRARLREIVSSLVSTTREVAASNQVLEARMRESRAEIETLREKLEETRLES
LTDTLTGLSNRKHFEEMLAKAIDASAQRALPSSLIVLDIDFFKRFNDLYGHLTGDQVLRL
VAIVMREHVSKDATLARFGGEEFSIVLPGVDRAAAKEIAERVRLSVMGRELIKRSTGESL
GKVTISVGVAVFRPEDTPVSMLERADLCMFAAKRAGRNRTIDDSVAAEILQNVA
>A0A124ZZJ8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. TAD18|TrEMBL
MLKTIDHEISKYAAPPAVQAEFAQHDFEKLRNFCRLTYAASIVIWLLFDLIVSFKGGQGF
TVLSVVFVCAMAALTIALGFIRKARHFDVLNLIFVLAITLGIRLIIFGLPADTQPIWLIL
ATSSILYNASVLPLSRWGFLAVVGVTWGVLNPFLMTEVQLFDLRGSLILCYFAFLSCLTI
YSFFKLRRVKLYNYTMSKLLLTQAYIDALTEIPNRRSFMTRATSVLAQNPRMHDHYLAMI
DIDNFKRVNDQYGHDIGDEVLKRTAASIKAVMNGYECARLGGEEFAVYLSGVRRADVERL
MATLCSQVRNDPAAHPVTVSIGLARVDDQDSLNQALAKADKALYASKHAGKDRFTFYRST
LTGRE
>A0A653M5L8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 8BK|TrEMBL
MQRLTLSILLLLSLFSGPSFASPVLLSAPSSGSVLNGQIELLEDVDGQLSIADMTDPAVQ
SRFQPAAGRTSVGQSGNPWWIKLSLQRSSDAPAQWWLEVGAVTLLDLQIFLPSATGQWQL
RQAGERVGFAEGRDHDYRRAVFRLPPLGEQAQTIYLRTFDPAGNSFPLRIWQLHDLEQLA
KREHLVLGLIYGVILALLLYNLFILLALRDPAYLWYVLTMAASLVFIASMSGHGFQYLWP
DGPVPPWLDRITLPILVSLGILRFAQALLSTRTTLRIAHSILNGCVVVYLLALAVNLAGY
RSETGLLIGLIPIVTVPTLLLSAVIRWRQGFTPALFYLLGYGSVLLSFVILVLRAAGVVQ
PGESTAYLFPLAVAAEAILFSFALAYRIQILKQEKADAILQADREKTARLAQAQANAAEL
QHSVELRTAELAATNERLRQREQALQHAAFHDPLTELPNRRYLVERCETALANARRHSEA
IALLLIDLDHFKPINDKHGHDAGDLMLQQIALRLREHVRAGDAVARLGGDEFAVLVCGAD
AEEHAREIANRLLAELAKPVMYGAERLTVTISIGVALYPQHAGTFTALYKAADEMLYRVK
TRGRSGSAVCGEGGELSNSARLHLDVLSVPSGLL
>A0A3T1E0I5|diguanylate cyclase|EC 2.7.7.65|Halomonas olivaria|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAVETLVESHGDYFADHFYQVMLEDPHASLFLSNE
QVEQRLNPSMRRWLKAMFAVDHADFASLVEQQEKVGQVHARIDIPVNLVLNGARQLNRRF
ISRSTPPSKARCRRGMLRCMSPTISIWPWKL
>A0A1A8T3H6|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MRLKTEESKLAIAALYRVLVASLVCCLFYNIFFFYFPSKYLFDILAPRIIMLCCLALLIY
FYVDPQAHFKNTVRAFLALVIASFVPPSLYFIVMAWQGKWLLIERLPPTSGITLSLLILG
LMMLPRRQKKYVILSWSLIAIPTFHYLIFHPAELHTERGYELVSLFGPACLILYVIYPYQ
SGIRHHMDEITVSLRRSEAEADRDFLTDVYNRRGLQHWLKQLTTNDKICVILIDVDHFKS
INDRYGHTTGDKVLIEVASRMRSIYFDKHAIARWGGEEFTVIMVNPNEQAFWAIGSMFQI
ALSNLPYKTVGKVTVSVGQSEIHSCEDFINLIEQADNALYDAKNNGRNQAIIYNNTLS
>W1IPL4|diguanylate cyclase|EC 2.7.7.65|Xenorhabdus cabanillasii JM26|TrEMBL
MHDGIVRTLQNIAGVAHDVRQRRAFSQRVPSAKIAELHELSQVFNHLLEELEEWQHHLQT
EKAALTWQPQHDSLTGLPNRATFERVLSTVMNDKFMRESAVILFIDGNRLKYVNDIYGHA
AGDHVLITIADTLKMKVRKTDTVARLGGDEFAILLPSANLEDAERIAKNIIHAMDTPIQL
PSGQHLRITLSIGIALSNADLTAEQLLSEADAAMYHIKQRGGGWYSADTTKINYLSRNSS
>A0A753FW25|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi C|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWVALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2N9BC83|diguanylate cyclase|EC 2.7.7.65|Streptomyces chartreusis NRRL 3882|TrEMBL
METESEPYVRLASLRQLHQVMADMNTARSLADTLQTVAEGVVAALGYELACVNLVRPDGD
LVVAAFAGNPAAEALITGRVGSRESWERRLGMGEHWGDLVFIPHTEGWVLDDDDVPQWYT
DGPAPRFEDEWHPADRLFAPMYAPGPQGSAACGELIGVLSVDRPRNGRRPGAWGREALQM
YAFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQH
GRILRTNDALCRLLGRPASAMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYV
WVSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRSRLSA
RLCQRAAPAHPGIVESHDAAYGHPAFDAIGHAFDFGAGTEPFDAYDHHVHTVAPDGDHDD
GTKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLSNGVRDGDTVARLGGDEFVILA
DGLGRADAQDLAVRLRNEIIQPIRAEGRAVRVGASFGIGWAHCGMTADEVLKSADERMYV
EKRSRPKQHRRAG
>A0A5Q9LE61|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNKHVNHVVRRLIIYFFICLLAGVGITGLTSSFETRFNSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVAFGFACSALLMLGTLSSYPDWLSCNPAPVVKQNDAVIYYFF
RNIMMAVLFTSSIILYYFRRRIMHSFKAHVMTFAACIVFTLMIIFLSWIFSSHSPWLSIR
FIDDLSHTFTPLWRSIIGWLLMAVWFIALILIIWFSKLRNIFWYSGAFFCSAYLFTIFQL
LSTVGELDQAWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVKAQHPLSVIICDLDHFKRINDNYGHIAGDKVIQFAASVLDSHSR
KDDAAARIGGEEFALLLVNTAEDEAQAIAERIRLAVSAEQTPLPERMTISMGVYTPHDGS
VTAEECVQRADEAMYEAKNSGRNRVVIWRRQGR
>A0A1J5R8Y6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFLKLDEYRIGLVSFLILVTLTVVTGISVYVVMRNQAESILSKSLEASLKRNANLLNSQI
AQAIDNTRKMVSRPPVIDNLIQINEIPDGIKSKAKLLQVAELFLAHNFSGISLYDAQGTE
VVRAGHLLQRPALHIPINTQRNIFLLWDGHFILHALTDILDHQGRRIGTLMTEADLKLST
DSLANAISIGKTGEIALCGPSEESPQDMNCYLNSATFREFQRLHRVIDDRALPMSYALDG
KTGIIFAKDYLKEKVIAAYTPVGQLGLGMVLKINQSELYGPITAPLKYIAALLAMLVIIG
GLLLYWMMTPLVRQLFDSRRKLMDSAQVLQKENEKSLALLHNASDGIHILDVDGNIVEAS
DSFCDMLGYQRDELIGMNVSRWDAKLTDSELVAMLRHQFTEKERCLFETRHRRKDGVIFD
VEVSSLPLLLDGKPVLFNSSRDISERKEKDNELRQSKKRLEELLENMSSGVAVYQAIQDG
SDFVFTNINRASERMDNVRREDLIGKTLMEVFPGSEQMGLLGAFRRVWQSGKAEHFPVSF
YQDERIFGWRENYIYKLDSGEIVAIYDDVTQRMQLQEELRNERDFMDAIVQSAGTLILVI
DRNGSIVRFNRTAEEFTGYSFDEVKNKPFFWQKFILPEQQSKIKSVFDSALSGNIQARYE
NPWVAKNGEKRVFNWTNTLLFDDEGKMSFLIAIGADMTEHKQTESLIRMQSDALRSSFNG
VAIADAADPELPLIYVNPAFEEISGYPASELLGRNCRFLQGEDRDQPELAEIRACLKEGR
AGRATLRNYRKDGTLFWNRLHIMPILDKEGRITQFVGIVNDITERKHADDHLRLISGVFD
HAEEGILITDKDGTILEANPACSRITGYDHEEILGKNPRMLRSDRQDPEFYDAMWLKVIE
EGHWSGEVWNQRKNGEIYPERLTISAVKNDEGDTIRYIALFSDISNLKDQQQQLERMAHH
DALTGLPNRTLLNDRLDMALAQTKRSEGRLAACFMDLDGFKPVNDTFGHEAGDLLLVEVA
KRMLAISRATDTVSRLGGDEFVLIFQDISDETECRQMLSRVMDSIEQPFNIKGHDIRISA
SIGVAFYPDDDADGDNLLRHADQAMYVAKQSGRGRFYFFDEVKG
>A0A1W1H9J0|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MLLRISANNNLPSKLKHLRTENLVMGKYSPLYIHEMGELSILHKNRTGKFSFLRKNVMSS
FFSLYKNGIAGFFVRLCFVFFICCSGDLIFCSGDLLYGYNSNTVRLNLTEAEEQFLREHP
VIRVSNEMDWPPFDFAISGQPFGFSIDLLNILGERLGIEWEYVNGYQWLELMELFKKGEI
DVLQSVYKDEEREELGLFTRPYFRDKTVFIISRYSKPVSSIDQLKGKIIVAPKGWAYESF
LRKYYPDIDLLSVRNMEEAFHAIVQGKADAAIELSGVAQFMFEKHYFDSLKVSGWFEEYD
RGLKKALHIMVRNDWPILHEMLEKGLESLTPGELIELEKKWLGYRNIYPSQKITLTPDEK
LFLEKNSVIRVANEMDWPPFDYMENGKPAGFVMDYIALIGEMIGIELELINGYTWPELLN
MGQQKEIDIFPGIWKTAEREKFLTFTPPYMKLTKVLVSKDNNLKNYPSLSHMKGKKIALP
EGYGTTELVVNEYPGPEYIIVKNNEEGMNLLEMDTVDGFVGTLGVVNYILKKHFMTDIKV
IMEIELSHDLPLQIAVRDDWPVMATILNKAIENVTSEQYDALVSKWIGTIDGLEKITTLS
IEEKRYLEQKKQLCIGVIDPLNMPYEYISEENTYEGIVADYYKLVCSKTGLFLKWKVMDS
VEAANKELQKGNCDIISVVNTSDSELVGINITTPYVEYPLVIATDNMAVFISALENLSKK
KIGIVQNSPFYYTMVKKYPAIEFVAVNSVPDGLFMVQEKKIFGLISTAPEIAHYIQLNQM
VDLKISGEVPYRVEFRTGVSKDNKMLLDIMEKASNSMTQEQKNHLFHNWIRVTYQKGLDH
AVLWQFGTAFLLIIAFFIYRHVSITRYNRKLTAINKEFVQANRKLEAISYIDGLTQIPNR
RRFDAVLETEWQRCERNQHYLTLIMMDIDYFKLYNDRYGHLSGDECLKKVAEVLHRVPGR
SSDFVARYGGEEFGVILPDTDEVGAKAVAKRILDDVQALKLIHEDSSVSDYVSVSLGVAS
VVPSRLLFPRQLVDFADQLLYQAKKGGRNRYEFLILE
>A0A1J5QNN9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MANRRVWRAELPEMMTGSDVLCIALLDLDFFKTYNDTRGHLAGDTMLADLAKSWAAQLRT
QDLLVRWGGEEFALALPGCDLPEALEVLERLRASVPDGQTVSAGLARWDGTETIEALMSR
ADAGLYRAKNDGRDRTIMAIGGDFAPGTGPRHTR
>A0A1J5RQT8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLKSLIQSLNAWSHWGCDGVESHSLQRKIFHVNVAAFIAILSMAFFAVLNALTGNAALIK
SDIAQIPFYFFVLAVPWLNRRGHAGFARWLLSLSVTAAIAANIWLANGSWLDLHFYFILI
ALLGVLFFPLRQWVSIVLLFVVNASLFVYCGYFGVEPDPALLSLDATTATIFRATYVSTS
LFTLLFITWLGEYVANKNERELEKLSGMDQLTQLPNRRRLEQRLAEKIAVSKRTGQRGAV
MFLDLDNFKPLNDAHGHAAGDMLLQEVARRIRGCIREIDMVARFGGDEFVILLSELGTDK
EDAKWRAAQVAEKIRVTLAEPYRIAARAAQGPTGQVEHRCPASIGVEMFVGGAMSEVDIL
KRADAAMYEAKEHGRNAVRFHEEKQHAWDNPQLPATV
>A0A1J5RK95|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTSPEALPITARKRSGSTGEPTREQVADPVRDPSPDSRLRELLRSVWSSADFGSHELTSF
AQPVMRREAQQGVFVLGTLTMLLMTGLALLYYSLRLGPAYVYAFGLLAALSGHTAMSSKL
VSDIKVLYLLGMVLLSGCGLAFTLLANRYGVFSAALFSTVVLLFMVVSLVPWGLREALSA
TGIVYFIFTVSTLGAVKAFDAQTLWTLQFVMLAGAMIVLTVVARTVLIRKAHIEARFKLT
VANEELYSLSHRDALTGAWNRHFLQEQFSDIVARHAACSQGSCFALIDIDKFKQLNDTYG
HLCGDRVLQRLVRVLAAALRTDDYVVRMGGDEFAMLLRGGQVQERIERALHGFMERDDSC
PELPALPRISVGLVYLPASVPASLEESYLRADKALYAAKDHPSLWIVEAGFPRQNPE
>A0A1J5QUS3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTDPDIQCPFPANEAQRLRAVRSYGILDTLPEVDFDTLTRVAANAFNTPAAVIGLMDSDR
LWFKSRLGLEVPQLDRQIAFCAHAIMLPGEPLVVEDLREDDRFKQNPLVTQAPHLCFYAG
APLVDRHGYALGTIAVVDTKPHEFTEAQRALLCDLSSMVITALESRNLMNQLGLLAMTDH
LTGLPNRVQFERVLNSEVAHALRTGEPFTVLYMDLDDFKGINDSFGHAAGDEVLCEVAGR
MKNQLRIEDLLARLGGDEFAVIMRKTDESSPEFLVRRIFDAVSAPISLSNGDKVGVGISI
GIATYADAIGSMTDLLARADQALYEDKRRKNSP
>A0A6N3A659|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MNDNNFYKAEGHKERNPALSEDDPHSTGLLFAQRNRMPRAVGLACLFLPLAGALVSQPVA
GIWWVILVLWAFVWPHLAWQLAVRASDPHACETFNLKTDAIMAGVWIGLMGANMLPSLAL
AMMVFITTMGAGGPRLCLAGIVLTLLSCLVTLQLSETAVNPASSSLILCLTVPVLLLYPL
LFSWVSYRNVTRLEEHKRLLRVMSIRDGMTGVYNRRHWEILLREAFENCRRQQRMATLLL
IDVDHFKTINDTWGHDVGDEAIIAVTRHLQLTLRGSDIIGRFGGDEFAIIMCGTPPENAI
SAMSRVHDRLETFRLPGTPQLTLRISVGVAPLTGEMTHYREWLKAADLALYKAKKAGRSR
TEVAA
>A0A6N3ETP4|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MTAHTWQSLCNKKYRLSFRLFLLLNIISVLFSFALPVSGLQAITLPFCLILGASTLALIW
HMKFPRKKINVTAISFIFGCLWAWHIVIKYRSISAEDSAWLLIALLSVLFIGSLAFASNI
IAFLLHSFPALLGCLWLSSGEMSLRMLYAFALPGIGITIQHVIQKRNDNFAQALMHRLMQ
ERKTLNDLSMLDPLTGLYNRRGLQNKLDNLLALSEGSRFVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVARFGGEEFLVLLNHVDLERARATAERIRQHVFDLKIPHM
FNESVATNVTISIGIAELEEGDIDAAIGLADKALYEAKHQGRNSILVASALQVA
>A0A0D7EB73|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MQQIPNHQLVAEWLRLLDGYPAEAAVALQAVAEEKSAELAEHFYTQMLADPHSASFLSHE
QVKNRLGKSMQKWIVTVCSATAHSDLDAVVDLQRKVGDIHARIEIPVSLVLRGSRSLKGR
LRQLLEQRELDEPVRRKAARMGADLIDLAVEIICFAYSQSHDRNSRAEEAYRLFSVSQNI
GVEKERQRAALLDWENQLMFDLAIGNLTGALPELAGSEFGLWFRHKASHAFQGSPESASI
LDYIKRIDQELKTIAAVQEAGERLTMLHQIREQTRSIKFLLDSLFEQANDLEAGRDVLTR
LLNRKFLPVVMAKEVLYARQSNNTFGVLAIDVDHFKRINDTYGHDGGDQILQQVGALLAS
NTRGGDYAFRLGGEEFLLVLVDIDANKALAAAEKLRESIAREHFRLPNGEVLQVTVSIGM
AVHDGHPDYERLLQQADQALYEAKNGGRNRCALHQG
>A0A1C6L4S3|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MMGMEPDTIDKEEAFQDTYRKWRVLIFKADIVSVLAVFIIEITMFFFLRSHDLIFQTVSV
YLARFLILPTIINITLLTIAIICNERYKDRPYLLNYVPIVLMSCLCIVVSCTHYVFTVTM
AVYIIPVFVTVIFSNRKMTRLITLIGVGGIVITVLVDVLLSQSEDVYLIPEAIVALCILL
TAHKFSQILIGYHKEKNDALAKGYQEQLRMKELLNYDQKTGIYGATAFNNCLIGAIDKGW
TDNLALAFVDIDDFKYVNDSYGHAAGDEVLVRLAAIIKEICGDRQLPGRFGGDEFAILLT
GESLEVYCSLLTEIQKAFRQQIYDFSEQRITVSIGLARLQEGWDAEMILQKADEAMYQSK
KNGKNQLTVFQ
>A0A1C6IE25|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNRVLVVSNIDRVYEHKEIASKYNAGFEYNDFYAPDIINDEEKVHEIIERYKEAGVPKYC
TLHGAFYDIAVFSEDKEIRDISYRKMVQSMDIAKEIGARGVVFHTNVNPYLVSETYEKRV
VEITVKVLEKLLDKYSDIDIYLENMFDCNPHILAEISKKLSKYDNYGVCFDYAHASIYGN
NMEEWIEVLSPYVKHIHINDNDLTQDLHLTLGDGKLDWNKFLEYYNVYFSDCSVLIETTL
PENQIKSLEFMEKLESERYKAAFAHNVTNNEIGINKYNKISDVKALAAEELLERIFYYMT
KLVEIKEFSETVDLLTDLGSTIVNSDRASFWFWDTSSKQYWTLSAQGNGRITIPEGTGIV
GRTITENRTILCNDAYSQPYFNGNVDKETGYLTRSTLCMPITDVDNEVIGAFQVINKIDE
NGNAGVFDERDINRLSIVVAFCEKSLESHLLHNVALRDRLTGLKNRYSFYEYYNKKVLPN
VYDVKFSFIMCDIDFFKKVNDTYGHNAGDEILRSVSKLFKNSVDKEDEIVRWGGEEFIFI
LKNKDIAAAKAFAEELRSQIEKSDFMVEDKILNITMSFGVSELNAQNNIEDNIKVVDGRL
YKAKRDGRNRVIDGD
>A0A8F6GYK9|diguanylate cyclase|EC 2.7.7.65|Methylococcus sp. Mc7|TrEMBL
MKNRDVRSGTGEAGSSSIRIAQSCAEDPREAVREFHAGVASQQPALVTFFCSSEYDLDAI
AAEIRRLFAGIPVVGCTTAGEIGPAGYRDHSLAGASFHAVADILTGLRQFDGARAYALAQ
ALLQRLEVSAPGARPENGFALLMIDGLSVRGEEVAHVLQDALGKLPLIGGAAGDGMKFAK
TQVYFDGHFDTDAAVLTLFSTPSPFQAFTTEHFAVTDERVVVTEADTAHRIVREINGRPA
LREHARLIGGTDGVAAFPGHGDTGDLLIRSADRALYAAKHAGRNQVKCYAGNGSGDSAWA
ASHSKA
>A0A1E3AY04|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MGNRKKEQDNYTLYQKRIYNENRILIHYASFLSVTVNTLAFLLSFFSEIMRSSRLIYALG
AILSVVCVLLFRFFEEKQAGTSAGWFYGFWSGILLETAVLGTLMHPHGNAVTFCVTLITL
GALLLDRPGRIFILMASASILCCLFSFLSKEISLALMDLINITISLIIGIFVASYTSASR
INDLLAKGRILKQRDKDPLTNLRNRKAAQKYITDYLERNSDLCAMLIMDIDHFKTVNDVF
GHMYGDKIIRETGTKLNQIFRSSDCICRLGGDEFMIFMTKLPDKDIVLKKAAQLNKSIFT
CLNKDHRKYMISASIGICFTDSVKSTYSQLYKNADSALYSSKQNGRNQYSVYRNELKDTS
IS
>A0A1E3AMZ4|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKEKWDLNSQKLGILLRNFADMIWEYDTETHRLFAEPECAKRFGLPEIVADGARGLVDAG
VLHPDYLPSLSHLFHSLEIQDCTLTAELLARSGISRDYNWYRVVFTSFVDSESGQLQAIG
FFQDIDYEVQQRLKLQHLANMDCHTGIYNAAAGRQLIQNKLMQQSPSTHNAMFVFDIDNF
KLINDTYGHYRGDEILHHFADILRCVCRKTDTVFRIGGDEFGLFAYNTDDEKLVRRICTE
ILCRTNELSEDCIPVSVSIGVAVNKEYAPSYFDYYRAADKAMYLAKENGKGNYRADYF
>A0A3E2KR29|diguanylate cyclase|EC 2.7.7.65|Citrobacter gillenii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVQDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRPGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A1E3AT94|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MDNERKRHSHEYQDLFNNIPGGAFLCGQDEHCIMTEVNQGFLELTGFGREELEEQFGCSF
TAMLHPADQKDVMERMLSLAEDKDKAFVNCRIRCKDGSYKWAADSVRLVRKATGGNQLFC
IMLDVTESGNAGEELRLSLERHKIIMDQTTDIIFEWDICADTLIFSSNWAKKFGYEARYQ
GIGNGEKFPHIHLEDVETLKKQMKDVRQGTSYTTEEIRIENADGNYIWCRIRATAQYGDS
GKPLKAVGVITDIDKEKNMIDALRRRAERDALTGLYNREETEKQIRRHLKEEPEEICALF
MIDTDNFKQINDCYGHLFGDAVLSELAAGMKRLTRQSDVVGRIGGDEFTVFLKNIPSREL
GEEKARNLLSMFSNLFKDEKQTVEVTCSVGVAFYPEDGRDFQSLYHSADLALYEAKSGGK
NQYRLFHSQKGTEKEQKSYSSLGAAIDSDQRTSGAPGDLVNYVFQILYDTSDLEWSIQLV
LEIVGKRFDVSRAYIFENTDDGKYANNTYEWCNDGIEPQKEELQRVSYEGLEGYEELFRD
GSVFYCRDIRSLKPVQVALFERQGIRSTLQCAIREEEVFRGFVGFDECTGVRMWTKEEVG
MLSLISQLLTTFLQKKRSIDRERQMTIRLNTILDVQDAYIYVIEDGSYRLLYLNHKTRVL
DPSARKGMICYQAFFCRDTPCECCPLTGGNGEIYNPQYQVWTKARSASMKWGDRDAWLLT
CFDISEFKRMQ
>A0A6Y0YUU8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGAHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T5I684|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
SLTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3QPK7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLF
MLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQ
LSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVD
YCPDNHTATRGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTL
DEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVE
SLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGE
VFGLLFTELNSAQAKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLV
MTEADKALREAKSEGGNKVIIHHI
>A0A8F6DXQ2|diguanylate cyclase|EC 2.7.7.65|Skermania piniformis|TrEMBL
MIFGMVHYRPKARVGWMFSIAALLLCLAGYLARGQTQLFELQDSPVPDILTASAYAALFG
SLIGFVRPHRCGWTADHFLDIALVAVCGLLASWTMLSWPVLANAAQVGPNEVVMAVYPML
DTVLVAVLMHWMLTREPQGIALTMVETGVGMVILCDLAVSLDTAGLTRLGDRYALVPFFI
GLGLFGVAALHPTMVKIGAHVDYLERSRHRAIVIGVVLIVAAAVPPVRLSADGFDRWVIA
GLLALLLLTLLARSERSRQREIRAQHLADHDALTGLPNRSALLRSLSAQPATVSVLFIDL
DDFKAVNDRYGHEAGDDLLVEVGARLRASLRRSDTLGRYGGDEFVVVAPVDRADALVLAD
RMRAQLAAPFVLRDGSRLAVSASIGIATSAAGLTRDNLVRYADRAMYAVKASRRAGVAAY
DLERYPDRSGPTWVSIG
>A0A1E7WBN8|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MDSLLKHMVDMTGHRDHTMLDISVISAVQELAQASRTRVLTLAIVRGKIFVRPRAQITAG
EAATMVDTSDLQQPGEPIGSYPALAACLARHEASAAVANDNGSHTLWLPIWLGDKADTCL
EIVHPTPYTSATIQVIGGVVSVYRNFQNLLDYSERDSLTGLLNRKTFDDQLAKMLAASAD
QDSLTLPGELERRQHGDEERQWLAVVDVDHFKHVNDRFGHLYGDEVLILIANLLNTSFRA
QDRVFRFGGEEFVVLLRGTTLDNARKIIERFRQNVAAHDFPQVGKVTVSVGFVSITAFEP
PVIVLGRADQALYYAKSHGRNLVCHYDELLSEGLLQSTESNDTAEFF
>A0A378KWL2|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MKNILRNFLLFNLQFDEHEREIKYRFIFLNNVFFFAGVVALGMGFVRWQHSMLMGMIDFG
FSIIGFSLLYYLRHHKEKIEGISTLALMLTFLLFYAIYILAPYNTLRLALFFLLSASALF
LKGRKKGLLWTLFILVTVILGRFIPNLNTEYSWFDVVFLCINLIALFFIFDNYELIKEEQ
TEYLEFLNRELEKKVRERTRELHLVNETLEESEKRFRSAFDNAAIGMALVSLEGHWLKVN
KSLCKIIGYTEQELLKINFQQITYPDDLQKDLNYVRQLLDGIISAYQMEKRYICKNGTIV
WILLSVSLIKDAQGKAMYFISQIQNIDAQKKAEQELVTMAYHDVLTGLANRKLLEQSFKL
TMAYAKRHHYMIAVLFMDLDYFKQINDVFGHNVGDLLLIEIASRLKSSVRSSDIVGRQGG
DEFLIILSELVNEEEVCTVISHLFKAISQPFFIKQQEISITSSIGISMYPEDASDIDTLI
KQADAALYEVKSEGRNNYKFYTHQ
>A0A212LNS3|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MAILIVDDSADSRVLVKRLLEKNGFSEVITAETAFAAFDLLGMDRPACVATRIDLILMDV
IMPDMDGIEACRLIKANRCLKDIPIIVITASDITETLERAFTAGAMDFITKPVKPLELKA
RVLSALKIKYEIDQRKAREAELVKVLEELENANRELSRLSSLDGLTGIANRRHFEQIYDM
EWRRAARTGSELSVLFLDLDFFKYYNDTYGHQEGDDCLKQVAAAAGRVLKRPGDLLARYG
GEEFVVILPETSIAGAVEVAEAIRQAIERCNIPHSASPVAAHVTVSVGVAGGRVTQEDKP
SDFIARADKALYEAKHSGRNRVKVADC
>A0A2R8CLG3|diguanylate cyclase|EC 2.7.7.65|Kushneria phyllosphaerae|TrEMBL
MKVFFARHGDLLLTLLALPCVVAGWWLTPPMAHLLLAMVGMVTLSRLAMNATRRWRPHRL
RPFAVILTVVTLIPLLALLCSFLLPDTVMNYAQWSLLFDRWPGQVPFYSLRPSILITLAL
LLLALLPLFSSRSAEIAPIGLAIAAMLTAMHLVEQHWFVSLHEVSLSTLTLLTIVLLLGA
EVMTQWPKRRPGAIGIALAASMAVLLVLLVLWHYHNSQNIREVNQVARTRVDTLSERLGQ
EISVSDQAMQRFAISWDAAGSEPSSRAWTHRARHLAEHFGYLQTIAYVDRQGPRIRRAYP
LQSNQPLLGHHVLSNDDSETLAGALQGQATATGMVNLTNGGRGVIFYQPIHDLDTAAIKG
VAGFVVDPARLFATLDDAADSHNFRIRVMQGGNTLYSSDTREALSMLEHCNILRLGQSNF
TICAEASYARLFDERSKLPAVVLITGLVFTWMIYLLMYFLHRLRRRHSGVKDANYRLRGE
VEKRIALQQEVEWLAQHDELTKVPNRRYFSQWVEKLDTTHPRTIIVVDIDHFKQINDLLG
HPTGDRYLQDVAHRLQDIVTTQGGLLARFGGEEFIACLPDITPEKAAEVGEQLRHGIEAL
TLTRHDGQTLVTISVGLITTRRASDTLPELIQSADQALYRAKLAGRNRVVVAGALDARP
>A0A212LY64|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MANILSGFTTIPFGVLVVIFLAYFQMPVNDALFAMLDSSAYILYGAGMILSWWFNRSRVF
FITMLLALSQHALSGTAAADTGIAALPAVLYPVLCTLLPLNIFVFSLLKERGIFNTWGLG
RFAIILFQVFYVAMAITANDSTMLSFFHKEFLAEDLSGITKIPQVALLAYAAAFLLLFIR
QLKTRSRLDRTFAAVLVSTMLGLQWQAEPLALPVFFAAAGIMLLIAVIQDSYSMAYLDEL
TGLPARRALKEELMKLRGEYTIAMVDIDFFKKFNDTYGHDTGDDVLCLVATVLRKVTGGG
KAFRYGGEEFTIVFPHTPLADALPHLEKLREAIEKTPYAYRGKRAQKTKKKATKKLFVTI
SIGAAERSEKHAETHEVIKAADTALYRAKKKGRNCVSK
>A0A8B4S595|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MFSNNDFILVLTPSMAILVLAAILIVAWLVQRSQRFLLWQACAYSLTALPLGAQSLLPLE
ELNRYALLIGCFYLLSAWCLARSWAERWRVSTQPHAALIIAIVTLTALYQFSRVEPNVWA
RVSSFSVGSGLVLLLPILQIRSKKYSFDWLDQSLLWLSILFTAYTFTRPALIWLLGYSDL
RSLPSSPYWILTLLSILNFSLLFTVVMTAIAVKETVVKLHMERDFDALTQILNRRSFQEY
AQKRLDELRLYPMAVLACDIDHFKRINDTWGHERGDKVLQLVSAILQSNMRENDLVARFG
GEEFVILLTNIALKDAEAIARQIQLDIGSSNDILPSGSRMTMSFGLSSITQAFQFERALK
EADQLLYQAKNAGRDRVYVSGVDYPDIPIESPRQSDKIAA
>A0A7Y9HME8|diguanylate cyclase|EC 2.7.7.65|Duganella sp. 1224|TrEMBL
MSEAQAIAHDQEPVLPTFKVRVLLVDDQLIIVEAVRRMLSDQPDIEFHYVTDATKSLETA
LQLQPTVILQDLVMPTIDGFGQITQYRAEEGLRHVPVIVLSAKEDPKLKAHSFATGANDY
MVKLPDKLELLARVRYHSTAHISRLQRDQAFRFLRESQKQLADANIELQKLAALDGLTGI
ANRRRFDETMQLEWQRAQRDKKPLTLLLCDVDFFKLYNDSFGHLAGDLCLKKVAAVLTEH
LKRPADLAARYGGEEFAIILPETPLTGALIVAESCRRHLEQLAIENPQATTELSSVTMSI
GVASAVPSPASSVEELIQQADRALYAAKHAGRNRVMSAESLPGPTSSNEGKTAA
>A0A6N3EV29|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MKVKRKLPLLMILLVVIPLLILSSIISIYMSRSSLEMRKQALSDVSESIANYLEEFYKTQ
MDDLEFTAQIPAFAKSLSDPSNSELLEPAQQLLNISAKTNSVVNRNSIIDLSGNVVASSD
PNYQGTNVRDSSMFKTLIEQNKDSYNEVVDTPSNGSKCLALAIKIYDTSQKPIGILNRNV
SIGSINQQISQRKVGDSGYVYILDSKAKQLSTIMEEGLSSEESQENALNNDADLKKFISD
VENNRLKSNTGFFTYNYDGTPVIANYEKIPTSGWVVVVCMTQTEVFKEANTLQTMLLLTT
LTITLVALFIGIQLAKTITNPLTYLTEKIKQIQHENFSVRCEIPGDDEFHELADNINQMT
ETLEISKHELVKTNELLKKSAYIDGLTNIPNRKSIYHTMDTLFRKYNNQALFLFDLNGFK
TINDTFGHHMGDAALNAVAKILKGIASDNVFPARLGGDEFLIFINNYSNPKDVLDLAENI
LRNIENIKNLREHPVNLSASLGITFLKDDTINRSQWIRQADEAMYDAKHNESSAYAIYEK
EADLFHED
>A0A0F7KSR4|diguanylate cyclase|EC 2.7.7.65|Croceibacterium atlanticum|TrEMBL
MNALIRIETGLIRALLLVAAVVCAGWSASASAERWLAQPFCHAVTPIEAGDTPPSAFDCS
GKADNYQNASLWLRVTPTPAKKAEGGLTLVVQNTRFDRLMVVFNFSDGTVERHQVASGSF
GKHAALGAQIMFNAPEREAQIESVTMRVDRLASIDLLRIRLMSLPESNRQSSALSVIIGA
ALTLLGIGAVYNLFFAIAARRQFAAWQSAWAACMMLWGAIWSQLILFVLPGMAGAPSAQI
STAISCFAVTLATTSAVTSLSSDHVPRLLKGGTLALGGAVGLIGIPLAIMRSGPIMVLAD
VLALVILADLLAVALCIGWAMRSGSREARNFAGAWSMPMLMLAATFLVDTGQMLWGGGSH
LLVLCAAAWQTIWISISASSSYAHLRMERDNARKAEAQAHELARRDPLTGLCNRRGFIET
VTGMTQRSAGRRKPVALLLIDLDHFKQVNDRHGHDAGDRVLTCVAEILLTWEGPDCAVAR
LGGEEFAMLVSGLKGDALINFADHVRTEIAAYEFGPLLDGAKVTASIGVAERPDADFHSL
YRLADKALYAAKHNGRDRVESNHVPPENEAQGRFIEELAEGS
>A0A8J7W5Q2|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MILKKMITQIPEKCKPEFIQSLQTENLKHTMIGTAAFIAIEMVVAFFIEDFLSPTFLLSI
GLILYALLFLPMIYFTYKRIDKLPFSWVQSIQIMFLLGLILGGVLWTVMEQQGFSSASTY
ICTIIAIAAFISFTPVEGAFLYSIAFLLFILILPRYQHNVDAVQTLTVNSFLMSILAWLL
NSMIFQGKVTAYQHRKTIEEKTLELERINKELEEKNKELKEMSIRDSLTSLLNHKNSLKR
LKEEVERAKRISYPLCVAMIDLDNFKHINDEHGHQTGDDVLTIVAKILKETCRTTDIIGR
YGGEEFIIIMPDTGADDAGLLIKRIQKRILEEEFEKGIHITFSCGISELNGESVHGIVRS
SDLMLYRAKKKGKNRVEIRKSAHHA
>T0HXM6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium lindaniclasticum LE124|TrEMBL
MGGDLRNAPLKEADEDSGDGLVTALKNIVEANADDLVALFYKTLLQDDEAKHFLNYSVVE
TRLTSSLRAWLVELLGPSDIRESPDIQDRQRIVGEAHARIKIPVHLVMEGALVIKSRLAE
LIAVDIDDAAAAIANVQLVNDRIDTAIMLMSKAYMRDATARARLDEAYRLFSLDQDIGIE
KEAQRASLMQWSQETLFALLGGSLSLSKLSTSQFGLWVRHRAGLMFERSPAFENLTAEIG
RIDNILLPKIESGNGRSGDNDALHQLHSAVNEILFIMNDLFQVLNSMENGRDPLTRALNR
RFLPSILGREITIANQNKSALTILMVDVDHFKSINDRFGHQIGDVVLKQVAQVVMENVRP
SDFVFRYGGEEFLIILSETHLNEAKGIAERIRTDLCDRELDAEVPQVLKVSASIGIAEHL
GHPDQNYLIKAADEALYQAKANGRNRVEIAVAMALSENR
>A0A5I5SWZ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Isangi|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2U8FUH9|diguanylate cyclase|EC 2.7.7.65|Aquabacterium olei|TrEMBL
MLSLSSTPPSPPDHHAPEEEWQALVHSVTPACRQLVAAVADRHAEALADRFYEVMMAHPR
AGAFLAHDVVHERLRASMARWIREVYGDRPNEVATLVAHQRHVGEVHARIQLPINLVTRG
ARTLKRAMAERLVAACASAAEAQEAERYAGHLMDLAQELMSEAYLRNTQRGARTDEAYRL
FSLGQNMSVERERQRSVLLEWGQELLFALHRSSVPGALPRLAHSEFGLWFNHKAAAMFEG
APELEQITEIMERIDDTLLPQLGGPEATAPQPLIMSLQTELDNLKFQLNTLFERQLEVEN
GRDTLTRLLNRRFLPSVMSREIKLANERHTQFALLLIDVDHFKRINDEEGHDAGDMVLQQ
AAMLVLNSVRNGDFVFRYGGEELLVMLVEVTPPVAQRIAQELCERFAAADFLVGQGRKLH
ATVSVGVAVYDGHPDFQHLINRADQAMYEAKQGGRNQVRVAG
>A0A2S6Q4G9|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MENSNSTELVTELLQKITLLEGKLEEKNIEVAQLKKLCETDSLTQVGNRRKFEKNLKSII
SYNKRYKRQSALIFLDINKIKYINDNFGHDTGDQAIIFTAQTLSQYIRDTDSLYRFGGDE
FIIILHNVSRDMAEQKMLDIQIDFNSKKFEYQDYINTLTVSAGLEMIEGNTCPITLINSA
DRKMYEEKRSYERS
>A0A5B1CN21|diguanylate cyclase|EC 2.7.7.65|Rubripirellula obstinata|TrEMBL
MMMMMIANVALVGSLALFGSIAFAVLLLCGGIVLGIKIGRKRSQASGEILSENDRENMLQ
LLQQLGSWAHEYSGNVSNYQAELGKLSDAFESKSKRAGATPADSQVMLLLGQIMKSNEAL
QNRLDVAERQLDKQTQQIECYLTEARTDGLTGLYNRRAFDKRLDEVFAEYKNGGRSFVLV
LVDIDKFKTINDNYGHQAGDQVLQQLAAALRSQLSGAKMVARFGGEEFAAIMDGPLQIAA
KRMDEVRRVIAKERMDAGDASLQVTISVGVSEPREDLVASPIVRRADEALYAAKNIGRNR
VYYHDGKAPSLVGAAEIAK
>A0A7U8VD95|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MMDKPLRLKINKLRHLTSPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANV
AHEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRT
LPVFGVSGSVVGNNPMLLKDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFF
TSTLPLRDESQVMTHYSQAISALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIP
LDFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSP
REQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTL
MWVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQ
RSGRPLSVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVV
LPNTTLQDAVAVAERLRLRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVAD
RRLYLAKQNGRNQVCFRSEA
>A0A7U8YXH9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENNAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A6G7GU86|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MDIKDKTNTAGSMDEIKTKQQLIEEIKILRQKLSEYETRQLKVEQAEEAAAWEAKANAAL
VDLSKALVKPENSIESLSALVLEYAKCLTNSPVGYVGYIDKQTNSFVSPAITPEVSKIFN
IPEGNIGVDEFQGLWGWVLENKKPLLSSDPLNDARSEASLNKNASLKHFLSAPAMLGEII
VGQITVGNAANGYSGKDIQLLERIAILYAIAVQHLWTQEVITHMAYFDEITNFPNRRLFN
DRLYVAISNANRYRQRLAVMFLDLDGFKEVNDAFGHQTGDQLLREIAYRLNQTVRKSDTI
ARMGGDEFTVLLTQVEHESNIISVADKILEAVRQPVVLDGNTISITISIGIAQYPDNGKD
VNTLLKSADIALYRAKESGKNNYQFSSFSEDSLRGECV
>A0A448KWJ4|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MTRRHRHNLLLAAISLLFLFSSVWGLYLQHRHEQLVDTLYRNIHWNISQTMLESQRFLYD
LRLYRAGALEMEVLSLDYDLLWNRLDIFLISSETADARGRYGLGKVVARLFDQIKLLEPQ
MQAGALQEGGALDRTQARIVELTHQVEQIGNQILSGQEREASVNQIRQSLFWLQIWQLIL
LVTGGVLVFALIRVNLQNRRLSLLDPMTRLGNRRALQAQLKQSLRLGRAQALVVLDLKRF
KQVNDLLGYQVGDRLLQTVAAKLRQQYPGRAYRLGGDEFAVVLAGGQEAIEQQMEGMVAL
LKFEFVTRESSFDLACRFGVAQAEGEDAGMLLEQAILALNQAKRDDATLIWFQPAMKAAL
NMGQRQLHQLREWLAGAAPSPLETVSEELEDERGQRVLAISLRWRVGQQPCDVDWMQERG
VLGPVVARLLAESTHPLPVLLVLHQQAQLAHVLAYLPALPAASLILALPTLTEDRLLLEK
MRQRGCVLALHELGSRVPELLRSGWPVRYWLPEPADNDVLLQPLAQRLGLLRLSRLGAEE
EMEDRVEQREQPY
>A0A8E5TZ42|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF15034|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7L6UJL6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C17|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARLPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQEVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A3S4Q8H3|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MDPILAGLSNSLPQAKTVEQLTRPLLDMLGSVTGLESTYLTAIDLKADLQHVRFARNVGD
MQIPEGLSVPWSDTLCKRALEEGRMCTSDVATCWSDSAAARQLGIQTYVSAPVRTDEGTL
LGTLCAASAQRHQIPSQAEAVLKLFSNVIANFLEREILMEQLQAANVQLMSYALTDPLTG
LPNRRAVYEELERLEKRALREGGSVLVGVIDLDGFKGINDTYGHQQGDVFLQEISRRLAS
TLRTSDMLGRMGGDEFVLIGPGPAIEHGNIGPGGEAQRGEAEDAARALEERATAATIGRY
QLGDAAVPYEGASVGVVAVDPRGLDAEAAVRLADARMYEIKRARKRARTIH
>A0A3S4T4K9|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MKRCLLWLLLLVASSPLQAGERSLDSPDRVVLQLRWLHQPQFVGYHMAKAKGFYADVGLD
VEIRPGGKGISPVQEVLAGRADFGVGNTEVLTGYAHGEPLLALASVYQHSPSVFLARRDS
GILTVADMRGKRIMMFPGHQDAELLATLYYQGLHERQLTPIPTSVNIDDLIEGKVDIFNA
YLSNEPFYLEERGIAVSIINPRNYGIDFYSDILFTTQAQERIDPARVERFRAASLKGWRY
ALSHPAEAIALLRKEYGVNRSQAHMEYELQMSKEMIQPLYVEIGYMNPDRFGHIMEQLTE
IGLIPRPLPLADFLYQAPSEQWAFWRPWFLLSLAVGALILLLSIYLLINNERLNREVALR
KLREQEILQLARQDPLTGLPNRLSLMEQLELQIQHPDPGCLLFCDLDSFKQVNDSYGHSC
GDALLCQLAERINHSLGHRRFFARLAGDEFVLLLPDHDSWQAEEVAEVIRLAMIPPFEVN
GHSLSVGISVGVSPYQAGWSAEQWLINADQAMYGDKGIVLEKQRTLG
>A0A1V5I7R0|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.BinA166|TrEMBL
MLDEPTAGLDPDSSDAFVTLLRALHQELGLTRRYKTHMSLVLVCLDDPEKPGEALGMENR
ERALGELLSALKGRLRPTDHVGRWNLAVLAVLTPMSGPIALQEAEAIRDLASRIRLRGEV
KVKPSVGVAEYRVDLSTGELVKKAEEALAAARRAGGNRIVLAPFR
>Q3YYN4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNF
ISHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTR
HLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQ
AKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGH
ATGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPF
DLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>Q3Z1Q8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MLADWFSEQFSTGVLIVPLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKG
LVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASY
RTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A380PAU3|diguanylate cyclase|EC 2.7.7.65|Streptomyces griseus|TrEMBL
MGDDLRLRAVVGLAQAMAAAQSPREVWRAAALGACGALGGGFAALSVWERDRGRLRVLVN
AGRLAPGEEEYPESETYPVHQFPEITEFLHERWAGGGEPDAWVETADGWAEGRPGYCHQR
VAALRRRGRGCCVVAPIVLHGRAWGELYVAREAGEAVFGPGDADFATVLAAVVAAGIVQC
ERLEEARRLAYTDALTGLANRRAVDARLDEAVEAHRGEGAVVSLVVCDMNGLKRVNDTQG
HAVGDRLLERFGSVLSLCGAMLPGTLAARLGGDEFCLVSVGPGADEVVAVAEELCERAYG
LATGEGVACGVASTGDPIGEVRSARRLFRLADAAQYRAKAVRARGPVVAGREAEPETGAD
AVLRLADAPPPEGGERRRIRGRRDGNGGTGGAG
>A0A8B3W6T8|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPHTTDPITGLKKRTLPLVVFFATFLMTVLCFVLVAANQNRSLNENLDSFAQHQTLSLKA
FIDNDVAYIGSGANFFYSNDVDSRDRFDRFAQQTINGSKSLIGLQWMQKVAVEDLAEHTA
KMKAQYPSYRMFTIPKHGPKTYGYVLDGEPVFIATDIYPNDPVNNGVLGFYSSRERFNLI
IENIKKTREANISDKVRLLQDGLDSNTPKSGMLVYHPVFDGQTDNLLGVVIGVVRTTYYF
EKLLASTVGDMDVYVRVTDSGFEAEDAPIMFETNGYEAVTGQHITKTITLTNREWIIDFK
IDACISFNGYLVLAGIGIVGTTISLLLAYIVNLQIREKERLYRMIDERTEELRFLANHDS
LTEIYNRRAFNKMLGQSIQSDKPFSLIVFDVDKFKEINDKFGHPAGDALLIHVIKVISVS
LKSGDNLFRMGGDEFGIISSITEHDSLSRYLECILETVSESHCEHSGQLLSCTLSIGATI
RTNEDIEALLQKTDSMLYLSKSNGRNRVTIAG
>A0A7U7G8F7|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MNSINISAPASVVARLRQLLNEYQHTEIELRARLRASEARFRDLLEMTSDWFWEQDAQFR
FTYFSTGLAQTHIPSTELLGKTRWELSTNLTPEQWAAHRAMLDAHQPFRKFEYCIRTDAG
EERWLSINGQPQFDERGCFSGYRGAGRDITERRRTGERQRLAAAMFEATRDAIFITDTER
NIVAVNPAFTALSGYSEAEVLGRNPRFLKSGRYADAHSAPLWEVVGRKGFWQGEFWNQRK
DGETYAVLTTISEVRDASGRPSHYVGVATDITHQKAAEQRIEHLAYHDALTDLPNRALLG
QRAELALALTARRHEALALLSLDLDRFKEINDVLSHTEGDILLVQVAARLKTLTGDTDTV
CRIGGDEFVLLLPETDQERALRVADKILAAFRQPFPVARHSLRITVSIGIALYPHDGSNV
TDLLKNADAALHQAKQNGRNTRTFYAQEMNAAAFERLVLESELRRAIAASQLCAYYQPKV
RLSDSQIIGAEALVRWRHPDHGLIPPGRFIPLAEASDLIAELGDWMLKEVCRQQAAWRDA
GLPPLTVAVNLAARHFRNSGLVAQIQGLLAAHSLPPQALELELTESSLLEIGPNTEETLL
ALERLGVGLAIDDFGTGYSSLSYLKRLPLTALKVDQSFVRDLVSDPDDRTLAATIIALGH
GHGLGLQVVAEGVETDEQRRILLDQGCDLAQGYFFGQPVPAADFVAGWIRQGFSDVQDAV
ELTEA
>F5NTC4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRAMVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGLQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A8B3W115|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MTLYKQLVVGMVAVFILLMTSVFMIEFNTTRGYLEEQQRSEVSNTINTVGLALAPYLEEK
DKVAVESVINALFDGSSYSVVRLIFLDTGDDILRSYPVKPTGVPEWFTNLNLFEPVHDRR
VITSGWMQLAEVEIVSHPGPAYDQLWQAFIRLLGIFGTIFLLGLVSISWILKRALRPLSL
IITKMDQIAKNQFGEPLARPKTKDLTLVVDGINHMSTQVELAFKNQAKEAQKLRERAYID
PVSQLGNRAYYMSQLTQWLEESSLGGLAVLKAEFISEEYDEKGYQEGDALVHQLAEQLQA
SISSPDITIARISSDEFGFIMPNIDESELKLVAGSIVNCIQNLGSDPTGTANPHIALGVT
YSNTRKTSTEIMSLVDNALSSAKANRELTYGYVTADDHGAVMGKQQWRMLVEEAIINDLV
TFRLQAANNSFGKTYHQEVFSAIEKEGVRYGANQYLYALEQLEMSHILDQYVIEKMIEKL
NAKEVTRPVAINISPSSISQPSFIRWIGKTLEHNASIAHLLHFEIPENCFINVPHYTALL
CNTIRNADSVFGVDNYGRNFQSLDYINEYRPSYVKLDYLFTHNLDDEKQKFTLTSISRTA
HNLGITTIASRIETQTQLDILSDNYVEVFQGFIVDK
>F5NUG1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDR
>A0A2G4AYP3|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLLVDSAEESDKQYGIENQGVTRSLAELTQIINALEYNITALYPLHGDTYVFSHDKKIED
ETCYFTSEEQHAPRFDFMFSGPREMCDPKSDLYTEAGKRLFIAPTMAYFANTIETISAIY
FISKEKFIISSPSDIAQYMKGDTFDSVVNSRPYWINTIRFGLAQGQDQVVYTGQYDDYLT
GKKVVTLTKGIYVNGEFKGVLGVDGYVSNLVSNPTHGYKVTSTRGANKYGFMDFTYSKPL
YVDDINTQLYLSIEEDKIEHFLHVLAMEKIQLSILLVLYLLSVLWLWRFYTRQEHQRLND
LAMRDPLTGLLNRRGFEARLLAQDEQPIIGVGVFDIDDFKVVNDQYGHKTGDEVICHVAQ
LMLNSVRQQDIVARFGGEEFVVAITGESSELLSSIFERIQNDISLQSYRCPTGDKVNISV
SGGATLYSLYKFDSVGHLWENQSIRSSDEQLYKAKAAGKNQVCIQVY
>A0A174NWR5|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKKAITFRLCAVIITAMVMMALLGYYLQTKSAKEAMRTNSELRFNQVSEVLERNDTEIGE
LRENLKEDYFIRAKAAAYIVQKQPEVADDLEEMRKIASLLRVDELHLFDKKGRLYAGSEP
KYYDYTFQSGEQMQYFLPMLDDYTLQLCQDVTPNTAEGKMMQYVAVWREDHEGIVQIGME
PARLMAAMEKNELSYVFSMMTTESGVTIFAVDRETGTIVGSTGDIPAGTTAEALGLHLPE
DMETGVPYERELDISGTKNYCLVELTDGIVVGVSATYEKLYENVPNNMMLILFSLCVLSF
VTVFLIVKMLDKFILSDIYGTIEGTKKIAAGNLDYRLEIDHTPEFKELSANINRMVGSLL
EATGKLSFVFQSVDIPIAVYEYNQDMRRVLATKKLGEILMIPEEELRTVLADRTLFVERI
RELCAEPLAEEKEVYLLEGSERRYVRITSYEGEGRTLGIVIDVTEAIVEKQQIEQERDID
LLTGLLTRRAFFRTADQLFADPGRMKTAMLLMMDLDNLKHVNDTWGHEYGDKLLKAAADL
FAGLKAPEKVAARLSGDEFVLLIYGADEKEELYACLERLEKSIREARLALPEGGEAEISV
SGGYLIYPEVGCDCTEMLHLADQAMYRVKKSGKGRFEKYGR
>A0A174DFW9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MQRGKQPLWRRKIVFVVVFLVVNLISIAFLAVREKAAVNQKLFDQAAETEVQFGGIMETY
ERSFQLFAHMMAREIEHEPDPDSVRAYLKGMDASLLNIVGETYDGLYMYYKGQYLYSWDT
PYSVYEDSGYVVTERPWYQDAVAGKGEIVFTPPYMSYANHYILTTISQLQADGETVFAYD
IKMEDIQNLVSSMEQFQQEQILIYDGAGTVVGSTVPGYLGGNLQISLEEAAQNLEDAQAE
LDALKKDSGAETARAEDTDSTEDAVGAEDTAKSEEIAKAEEKRESAAAFLEFRQRLSEWG
KTSGDMSGSAKPVTMDGNRYYLYNHQTADCGMMVLVPEVTMLKATVGTWLVPFLVMELIL
IYVLGSVGRELRNQELRAAYVKMGQIQKRLELALSAAQKAAAVDDLTGLMNFKSFQTEVG
EQLDTMDEKDSGILIMIDGDHFKRVNDNYGHSVGDEVIRLSAQMIIGRIRTVDLASRLHG
DEFAIFVSNTDNYDVARTIMEDINASIAKEAGKRNMPAITLSAGAVTARRGGRYTELFKA
ADEALYQAKKTHNGGFASFEEL
>A0A550AC57|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MKRFRHKLYFKVAAAIALSAAIVAVLSSYFFYFDELARNEQDSREHVHQLSRTVEKTASI
AVYVQDSVLASEIIDGLAINDLVSEVELISEPGFSVFSGEGSLVGKEGVSTLLLYHPFSE
SEVIGELKILPNEAFIARNAKDAAVNQAQMLALLTVVTAILVSFIVHKTLTSPLNRITNK
FEEIKPGETCHITVPRFHQQDEIGSLVKGINALVSSLNQSIDSERNLREKTEILEKKFRL
IFEQASAGICLIDSENLLVTANPAFHRIIFKSHSIADAIGLCLTDWFYNKQQLESFLTDI
RQSHHLDTVALDLKMKTLAGSPDCWVHCLFSKVLDGESQSSLMIEVLMYDVTERTEREIN
TRFEADHDGLTHLKNRRAGRRSLMDLFERAKANSKIAVIMNIDLDNFKTINDDYGHEMGD
LVLIEVGRRMMSVFRNDDLCVRWGGDEFIVGCYFDSSHFETRSLPAIEKLAAELREALNK
QIKLNGELSIKIGGSIGIAIYPQHGDDLESVLSAADSAMYKSKQEGRNQYSIFNSELTDG
SSTCSKSHPKA
>A0A174PZB5|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKKENSFSRNHVRAVLLLVVLVLAFIYLFLYDFSRRVDHLMTDMTTEHLADVNDQSQTAV
KNELTRVFEEVRYTADFLSETPELTEESRQRVYEQLKEKCGFANIRLVSADGGLYTVEHE
ELPHSTGGYVEGICRGESGMTDVFPSSVTGQEVFAFYAPVRRGETVEGGIAGIMIVEQMV
DMVTTNGFNSGSYSYVLKSDGTVIMQTSHADSLYSGRDYFSFLRSDTDMGEEAVEELQEK
MERKERGVFLFTYGKEKRIVYYAPAQINDWYVLTVVPYTVSNWYREHIGKTALYLTVKML
LLFLAELAVIVLWFRKTRNIILDSKTALELEKKKLELALLHSTGTTFEYVPKDDSLSFIS
PPVVKTAEFPTVLYQVSAKGAACGLVAPEDLEKWRMILKRAAEGKEPDPLEFAGGTSFSE
DTYFRLSVTPVIVGKGEVANAIGTLEDITEERRIRRQFAQEEQYRAALLSEAVAMWSVDL
VKQQVLACTIHGKDWMEDGSGFLYSSRFVEKMCRYIHPADHDRIAGQMQANRMLAAYYTG
EREQKELFRAAYPGSADYKWMTCTISLLTEPVSGNPVAFAYVRDVDEETKRKMELLYSSE
RDPLTGLYNRRNIEEKVEQALKHEDSLSCLMMLDLDGFKEINDRYGHQEGDAVLKKMARI
LSGAFRSDDLIARFGGDEFVVFLERIPNRECASFRAEEVRRQVYALTMDGEDSIVSISIG
IAFSPQDGNTFELLYRHADEALYSAKGRGKNQIAFYGEEEEIMVLERLD
>A0A2S0VJT0|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium S05|TrEMBL
MDKPLRLKLKKRYFLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLNQRHQEIWRVALPNRRTL
PVFGVSESVVREHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTHYSRAISALWFTRQTQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMKGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMALASACQR
SGLPLAVIQLDLDHFKSINDRYGHQAGDRVLSMVASTLAGTVREGDLLGRVGGEEFCVVL
PNTTLQEAAAIAERLRLRIHGREVFLHNNVTLRVSASLGVSASEEQGEYHFEALQSVADG
RLYLAKQNGRNQVCYRSEA
>A0A383S0F0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MKPPAKRGPRPTLRTVLGRGHLGVALLAVGLAGISVTLLGVLALRVYANQNLHLIARSIS
YTVEAAVVFDDSAAATESLALIAASEEVADAKVFDNDGQVIAQWSRDEQGLLAQLEASVA
STLLVEPINLPIIHQQQNVGHIELIGQGRSLLRFLLSGLAGILLCTLLSAWVASHLSRRL
FSDIVSPLRSLAQVAHAARRERSFERRVPETHIAELNELGNDFNALLDELETWQSHLQSE
NASLAHQASHDSLTGLPNRAFFEGRLSRSLRSAERQREHLALLFLDSDHFKQINDRLGHA
VGDEVLISVASRIQAQLREHDLVARLGGDEFAILLTPLNSREDAQRIAEKIIASMKLPIL
LANGDNISTSLSVGIAYYPDDGHDPATLLNAADAAMYQAKRERRGHWQVAHTESGAADIQ
>M7NKX1|diguanylate cyclase|EC 2.7.7.65|Bhargavaea cecembensis DSE10|TrEMBL
MFYQLAINFCILFTFSVLSYWPFQDRVRFRIPFPRLHPILIGMMAGVTGLFLLGASVTIS
DGVIVDARLPVIILSGVFGGPASPLISALIIGIDRIMLGGFSGEALIAGSNTLLIGAVAA
LIFMWRGASFRTARFVFHYAAVQTGLVIIYLLPAGSNMVMNVSIFALYSYISFFTITFIL
AELSGHFKKLSGIERLSRTDYLTGLHNSRTFGELSEALLTGDRPVSLILLDIDRFKSVND
TYGHPAGDEVLRELAFRLKNFRLPEGAILSRNGGEEFSALLPGTDKQEAAAAAESIRRAV
GDNPFILDSGLSLTVTVSLGVSAHPEDAAGTKELYELADEALYRAKNSGRNRVAVHGTTQ
PVS
>A0A399E1Z0|diguanylate cyclase|EC 2.7.7.65|Meiothermus taiwanensis|TrEMBL
MRGFFLAISKSKKRAVYFWAILLAVPVLLFIWLMRPEEGFIRWLYPAFILMCAGWAWRLY
QGAHVGRIERETIGTVTLFFTIKLAYYLFWGDLERNWVEIESTYWVMAFVMVLLYIVFDA
RMGLVYSLALAVATLILGLLRLGGEVAQGLYRTEFLAFVRSEMRLLAMAGLLYALAIVKD
QLALANRQVEEMHALARTDPLTRLPNRLALSELLEGAAQHMHGLYLVLLDIDRFKQINDR
FGHAAGDEVLKEVARRLRVSMRKEDVLGRWGGEEFMILMRGEGQQDVLAAVERLREDISF
WPFKLVGSVSASFGVAEGHIGDSGHALVERADKALYEAKRLGRNRVEMSPA
>A0A5F0JWB9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. A11|TrEMBL
MQRDTFVVRRSFFQWLQKRSNPGLIVNSCFLVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQFGVDKALFFRNSMRDALQKPLAFDVLHQAVDRFDLLRNRPAWQLAVDK
ERTLPINGVSDAFVEKTVLLNRDDERIRNEISAALEVGYLLRLASSTVQNEERIIYISRA
GFYLSTDTPAQSDDIITRYYHLVTQPWFTQQSERNNRARAVRWFISTASSWTGNERMITA
SIPIYFEHYWYGVVAMDFSFSTMKRLLADATDDHAEGEYQLYDSRLNLIASSESPASLMN
RFDEREMAQIAHAIESDTEGGVRLGSRFISWERLDHFDGVVLRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYALQSSLQWQAWHDPLTRLNNRGALFERARILA
QQCQQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGIIASGLRENDVAGRVGGEE
FCVVLPGVALPEASVVAERIRARIDSKEILVKKSTTLHITASFGVSCAHEKGNYNFEQLQ
SIADTRLYLAKQGGRNQVIWRDDDKK
>A0A649YNX1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MEAKILNSVVEITEQRNSISLGHCLVATLLEMMPIESISLTHYLSNTSIVVAKVFRNSKQ
EEYQWTYDQAPEQCYMHDHKESAFNVTKPQTSSYICRYPIPISEESSALLQIETEADPVK
FELLIDGFAKIYRNYLMVLHESERDKLTGLLNRKTLEERLSHCFNLSVNQDSGLYAWVAI
IDLDLFKSINDTYGHMIGDEVLLMFSQQLQNFFSGSEQLFRFGGEEFVVLLPPQEKKQVL
KELELFRRHIESFRFPQVNNMTFSCGVCAISRHEYLPTILGHADVALYSAKEHGRNRIEC
YEDLILGATEPGDNDHLDDVELF
>A0A5W9CJ01|diguanylate cyclase|EC 2.7.7.65|Salmonella rubislaw|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>I6CAJ1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAILASIKPAGVVSRADVVL
PNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANPQPIAYLVLQADSFRMY
KFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIARELNAIPAQELVGHQLALP
RLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNKALLMEMLEQVVARKQT
TALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMILAQISGYDFAVIANGVQ
EPWHAITLGQQMLTIMSERLPIERIQLRPHCSIGVAMFYGDLTAEQLYSRAISAAFTARH
KGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMTSGKLVSAEVLLRI
QQPDGSWDLPDGLIDRIECCGLMVSVGHWVLEESCRLLAAWQERGIMLPLSVNLSALQLM
HPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRPLRNAGVRVALDDFGMG
YAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQSLNLQMIAEGVETEAQR
DWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>N9M8N0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. NIPH 713|TrEMBL
MLVQIAVFWGMDRMNNECMAMLAEQWKQICQNYSADDLLHAFHFVQEHSVILVEEFYKNM
LLEKESAQFLTDQMVQQRLRNTLIQWLSESFSVPINKSYVQAVQKQAMVGHVHARVGIPS
WLIMRGVREIERKVFELLQASSQNSMLTACSYIVQIMGFATEIMCRSYEAKTAMNQEIKH
SYRVFSAMQDVAVQKDKQRSSLLDWENELMFKVFSSPDNLKHPMLSKSEFGLWFIHKASY
AFTGSDQVDLIIERIYQIDAINQTIMDCTDKNNVLGLIQQIRDLNREIQLLVDQLFQVAE
YIESGNDSLTQLLNRRYLNTVISREITFSRKNHTPLSLLAMDADFFKSINDKFGHAAGDL
ALKFIAEALQKYSQGSDYAFRVGGEEFLLLLVDTDKQRALSIAESIRKYVENGMIKTAQG
QQFKITISIGCTLYDGHPDYQRFLDAADAALYMAKNTGRNRVYMAQSPSNPVGQQ
>A0A7S6Z165|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MFPVVFCMQIPDAPALNLIHATLLPGGVNATIGARLPANEDERVEALHAYRLLDTSPEPS
YDAFTSIAAAVCRMPMALISLVDTHRQWFKSRIGMQQNETPRELSFCAHAILEPDQVMEV
GDTHLDERFVGNALVTGEPQIRFYAGAPLLTPDGIALGTLCVLDRVPRRLSVAERDALQA
LARQVVSTLELQQAARLVELDALRDALTGRWNRAGLEHALHALADAPSSAADAPLGFMLL
ELDGFKRQKLQAGAPAADATLLQVATLLEAQLPPAAIVARLACDQFCVALPATAASAALA
AAEDLRKAVEDAHWPTGPLTLSAGLVDVATPTSLDSATLLARARHALQRARDDGRNRVHC
FDGWQLRA
>A0A1M7YQK7|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MNIKQILPKTRYTPSMKLHTFRWLLGFAIVCFASVWSIDEISGLISPFDEISYPVCICFF
TLTYIVTLIREVNREHLYLFTYFVVAGYLTSSSIYHHIALHGAFSNASQWLGLNYVMAYL
FLDVRKAAFTSIVVFIITLVGHYIVLMAQFSVSDALGVLFNIGMSHMVYIVLLWTVLRMR
IQSAKVQERLEMLEHYALLDPLTQVFNRRGLEDELLQAEQDCQLQNRPYAILLIDIDHFK
RINDRHGHLIGDWVLTEFISVLNKVTGSDDKLGRWGGEEFVVLKHHVSREDTFAYAERIR
MAICERIQVAEGEMLSVSIGIGNSGEAENSRDIFDVADRNLYAAKNTGRNRVMDTEYAGA
LSTTSKVC
>G7Z835|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MDSAGAVLDDRLPSDRLLRVTAAQWSAALVWTVADGTIVGANPAFACLAGCPLDSMIGRS
LPALLDIGGRDWRTVWDGAQGDHPPPGSGALCLPRRDPVPVDLHWQHLADGADTLILCEM
RGFDERERAEAVARLQQDVLELVAAGRSLKQVLDFLCRQVEACAPEVTCSVMLRDDENRM
RVAAAPSLPGAYAAAIDGLPIGPDVGCCGSAMSRGEAVMSADIAEDPRWAPYREVPLAHG
LAACWSNPIKGRNARMLGSFALYYREPRPAAPFHRRLVEACVHLCALAIEHDRARAEINR
LAYFDTLTGLPNRQLLADRATAALALAGRTRQPVTLVFLDVDRFKTINDSLGHAVGDQLL
VEVANRLRRLFIEGDTLARLGGDEFVALLPGCDAAHASLLAERVLASLSVPLTVADLTLT
PTASIGIAVHPDDGMDFDTLLRQADAAMYRAKQAGRNRCHFFRRDMNEQAVRRLEMEAAL
REALDRQEGGGASEAAGESGFELHYQPQVRLKPHCLYRVEALIRWTHPRWGAVPPMEFVP
LAEECGLIDRLDGWVLETAVAQLGRWRAAGVPVPGLAVNVSAVRFARGDLPDQVRSVLAA
NGIPANDLTLEITERLMMSEEAGAHDALDALHALGVTLSIDDFGTGYSSLSYLKRFPVGE
LKIDRSFVKELDIDAANRPLVRAIIQIGEALGLTVVAEGVEREAQHRMLEAEGCAIGQGY
RFARPMPAAALADWLAGEGKHWVECPANACFSI
>A0A1M7YSU9|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MKYNRNKIIETPLANNMVSGRLLAIRLSTLILSFIIIMTWVFARHEKNELREVLTHNSEI
AAWLVKEKLKTLPDVIFSDTRSSSQLIPLQLQMDRLRQSLNCKLYIISENGKLLVQDLHG
GPLQTLKNQQLMQLPALKPAIESILHGASSATYQAPDGRHQIRGIPLDEMDAVLISDIRL
PGYSQIVTFPLILLAVLGSTLSGVIWYIIRQTGRVWRRQNLAQSIIDPLTTLPNRKGMEM
ALRQNFSGPPEIQEAQSVLLLNLDRFSRINLHYGHPSGDTLLVQLAGILRRHIKIPHTVS
RWSGDEFLIFLRNSDRQAAASLAKEIMAQVQKLTFSFSGEHLQMHLSIGIHTRTPQDNLD
AFLSHVIQALQLAKEDGGQCIRHSDDALNHSATVI
>A0A8F8C2H2|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MSLHRDIHRRTYPLRASYLTLGGMVVAASLAYHPTNLAWWAFTAVSALVWPHIAFLHSRH
HQDPHHAEYVNQLIDAVIIGCWVALMHWSLLPCLSILAIGAADRFYTGLHRRWPSTLLAL
LGGMLLMAISIRPAPQWDAPLIVQLSLLPLIVMHSIYASWSTKRMLKKLAKQNFQLKLLG
KIDPLTTVSSREYWWKKARAALKQHQISQEPFSLLVIDIDHFKKVNDIYGHIVGDEVLKQ
IGLAIRSSLRSMDIAGRYGGDEFTVLCKHANAEEAYSMALRIRDRISEIRLREYPELRIS
ASIGVAAADASIGTVTEWIKAADIALYSAKKSGRDQVFDATERMSVSPRNPHSPATMPMR
LTSTALPIATEQHQSPERSAA
>A0A829CKC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MP021552.8|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8F8DD24|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8F8H0A3|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A245ZFI8|diguanylate cyclase|EC 2.7.7.65|Sphingomonas mucosissima|TrEMBL
MAGDLGQQLPGWSVTRWLVEPGGDIPDSTRRTLLRSLYSTLPIFAGGVLNTIAVSTLIAA
RMQTTAAYVWVALEVLLAALRLPTLYFGHKAMREGKRGPTDLYITLAVLWAASVGYGTFM
CVASGDWVAATLACLSAAAMVGGICFRNFGAPRLVAVMIALSLGPCVIAGVLSGQPILLL
TLFQIPFYLASMTSAAFQLNRLLVRTMKAEMINDHHARHDPLTGLLNRNGLSRWAGEHAA
RAEAGLAVLYLDLDWFKTINDTLGHKAGDAVLVAVSKRLQEIGGPHVRVARIGGDEFVLV
AENIGRDGAEQLKARISEAVAGQAYVVAGQNVHVGASIGVALSDDHGGTLSELLDVADMA
LHHAKTSNRAAWPAMGRGGAEPAVRRRALRVVHAHTN
>A0A221UWA9|diguanylate cyclase|EC 2.7.7.65|Arenibacter algicola|TrEMBL
MPKNNSTALEKTFNDLLKKENDFFNFAGESLIDGLWCWNSVHPESGYINGKFAQLLGYSP
HPNTSVQIDFLSLVHTEDLEGVQSAFQGLLSNSPNNPLNIDVRLGHTDGHYIWLNLRGNL
VADESEAGQGLIGTAQCIDRYMESERQLHINKDYYENVIKGANIGIWEGNLLTGEVICNE
RWADMFGYTLAELEPLTYTTFLNLVHPEDIGKIDVSLENHLKESGIYELEFRLLHKMGHW
VWVLSRGEVTKYGTDGLPEIVSGIHYDISNRKVNEILLEKYKDLFERSSEVAKIGYWELD
DQENTVFWSKVNKQIHGVSEDYTPTVEAGLDFYLEGENRERMKKVICESLEKPMEFDEQL
QIKTQKGKLKWVRLIGASEYQGNKSLRLYGLIQDIDEIKKVQLQIKFREEQFRQTFNHSA
MGMALINIENKLLKANKSLCHILGYTEEELQKIDLAEMAHPEDLKVNRKYIEELFQGKHK
YIKLDHRFIHKDGSVIWANISMSAIHNDQGQVIHYVSQVQDITERKHNELLLAHNAEVMQ
RINDAVSIGIWELDLGTNTVYWSPTIKKMVEVPEDYKPTLDEVYPFFQEGEHREALIDAL
GRAVDKGEGFDLELKVVTTTQRIFWSRTIGIPEMVDGVCTRLYGFFQDIDEKTRATKDLA
VKEEEMRQTFEHAAIGMIVVDLNGKLRKANPKICEILGYGEKEILEKTVFDFVHPEDVDS
AKVEFEGAIAVQGGFKTEKRCRHKDGSYIWIYEAVASVKNDKGELMHFVAQIQDISDKKQ
MTENLTEHNNRLTNFAHIVSHNLRSHTSNISMLLDLAVQDDPKVLENEYYRNVKVVSDNM
NETIRQLSEIVEINSQVSSTLTSQNLLKRVHKAMKTVDPVVRKNKATILAEVDANINVLA
VHAYLESIILNLITNAIKYRSPERLPELKITSGTKGEYAFLSFEDNGLGIDLDRHGSKLF
GMYKTFHSHPEARGIGLFISKNQIEAMGGKIEVESELNKGTKFTAYFRIAL
>A0A128EXN1|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MKILNKRIHIRVATGVATGAFLFSIFASITWFYISYHQEVDRSRSQIKQVITTIEQTASI
AMYLGNKELAEEVLRGLEANDIISAARLTSQDGLSASFSGNSDLDQADTAIIFPIVSPFD
ENEFVGDLLVYPNQRYIENNAISLAKIQVIVLVFYSVIIALLTLIIVNRILTEPMKNIAN
RFHIITPGDTTRIEVPVGHKENEIGALVSDINGLLDAVNNQIDNERDLRSETENLSKKFR
FIFERASAGIGLIDSGNQLIVANPALLRLLGQTFIVDTDRFSKTDFTGYFNDPAEIKEFI
EEFWLKPGNQFSAMDIQLKHKVRAADRWVHCLFSKVEDINNPDDSLLEVVLYDITERAER
EQNIIYEAEHDPITQLLNRRAGMAKLEVSLQEADKKQRKFAVLMIDLDGFKHVNDTYGHD
AGDKVIIEVANRIKQFFRGSDVVARWGGDEFLIGFSYNPNYETAVSDIASDLQFQIALPV
EIGHEQTACVGSSIGISVYPDNDEAISALIEQADEAMYYVKNNGKNFFRFYQAEEATASA
NR
>A0A1Y5SV52|diguanylate cyclase|EC 2.7.7.65|Falsiruegeria litorea R37|TrEMBL
MISRDDLAALLERLCPMFVLLDQSGHVQKVGPTLQKLRPDQPMLGQRFLELFELMRPRSI
STMPGLLSVSGAKLHLQFRDEPRTALKGVIVPLPNDGGAVVNLSFGISILDAVRDYALTS
ADFSGTDLAIELLYLVEAKSAAMEASRTLNLRLQGAMIAAEEQAFTDTLTGLKNRRAMDH
ILERLTVSSARFALMHLDLDFFKAVNDTLGHAAGDHVLQQVARVMVEETRGDDTVARVGG
DEFVLIFNGLQDKTRLDSIARRLITRLEEPIPFQSDICRISASIGTVQSSQFASPDPAGM
LHAADLALYSAKRAGRACHHFYESAMADLMGNSASSGGNPEQKDLA
>A0A1S7MY70|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum S56|TrEMBL
MEETAYRGIDRQTETGDTLRSTTQPVPGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADTDGQVNGILTDKPIGDDASILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDAEKPIATDPIFSRDA
VAARFATGFATIGDSSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLVA
LIVVLTVTGVLVTLIARHFLKPVPALVQATLRIAREETDVVTPFQDRRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEHLSTSGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQAVTDNCRE
DAGALAKRVVHAVSRSFSLEGSHISVDTSIGIACAPDHGNSATQLLQHADLGLYRAKSMG
CGFFVFYEPGMDMAAQHKHALEIDMKSALENHEFELYYQPVVNLESGRIVAYEALARWRH
SKLGIITPDRFITLAEENNFIKPLGEWVLAQACMDAMTWPRDIRLAVNLSAVQLCNDDIV
PIVDGALKASGFPAERLELEVTETAMLERDNSARALKLLKEMGVRLVLDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPENPMCSAIVNTIIDMAEQIGLKVTAEGVEDKKQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAQTGNDEYSDVGRPMQETYYPPQKAI
>A0A731NDJ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:r:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTAFGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X1AMX0|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MNPLADQTIAPVSEDELHAELARLRAEVAGLIERAERAEALADHDVLTPALNRRGFMTVL
ARNLAYCRRHGVEAALLYLDLDGFKGINDDLGHAAGDAALIAVAELLLANVRESDAVGRM
GGDEFTVLLMNAGAEEGREKARRLSEALQSEGFIWDETRLALGGSFGVRAYAEQADAEVW
LSEADAAMWLRKKARPEATR
>A0A128FBX3|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MWQRRINHFLSLVFSVLFITFSVSGLASAETTIDLSQWESGRSTVDKFRFIDDPSYQLTI
DDVVAITDWQRPEKGEVNRGFSTLPTWISFQLSNPEPVSKKVIVEYVEPSVETIDFYFRL
KGGDGTFTHQRFVYTEPTDSRPVSFYRPAFSVDVPPDSEVEVYYRLFQGREFPMHKFDSM
RIWEESDFYHSTHVELSLLVILLCVEIAMGLSTLLAYFATKDRLYLYYTAFAFSAASLFA
AFSGVWSYLIASQHYELWMVVLQINICQLVAILFVRHFLNVPEHSPRVDKVMLAVVTVVA
VGVVLNLLGKPYLSRIIIDFTAIGAFFLIPLGIYAHKKKVPHALLFSGSWVFFAIGMALA
SARLRGYIADSAFAEWLIYFGGLIEVILLTTVMILRFRHMQREKQRIEEKHWKYLENAAH
VLEERVKAQTKQLYEAKALAEKEARTDLLTGLPNRRSFFEGAQQFIERAKRNASPSVHLL
MIDIDHFKKVNDTYSHACGDAVLRHVGKVLNQSLRKTDLLSRLGGEEFAVIMENKPGEAA
QTMTERLLSAVEDSDIEFEDQFIRVTISVGMATWHPTQNLDQLLQNADHALYQAKREGRN
RVVYAPRENEVPLP
>A0A1P8WG60|diguanylate cyclase|EC 2.7.7.65|Fuerstiella marisgermanici|TrEMBL
MNTPNNLRSADATIRVSSRASRDAPLMVHRETLLRDLPPPGNHEYVLVSDDNDRLIGIVP
TREINRRLLASNPFERSRWVAMPIGAMSNLSLTDVSVENPTLERDELQCSAIREGDTLFG
LAVNGDLFLSWRRMESLFSAALSDPLTSLMNRLAYERRLREEWDRSQRSNMSIGVVVVDL
DDFKSVNDTYGHVVGDELLTLVGRKLEVAMRSYDVVARFGGDEFVALCLGCAPGDIEIPV
SRLLNSIGEIALNVDGDRVHVEASVGAAVRHGGFSESLPEELFVAADNCLYEAKKSSRNA
WRVEFGTGNEPTPEPIDCTEAITNEVAVAESAIAETTAAGNPTAPAPI
>A0A5B8QZY2|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MIYSFRNSGFRDPETGVYNQTYFMEVFNREWHRHIREQQSLALLYLCPHIHETVKQPHLL
EFFTKQVQEALLRATDLIARLDHNHFALGLFNIDEEGTEVVLKRIAKHIQEFNQEFGKNH
KLKIDYKLAACICLPSQEQKIESLFNHVSRLSLELERDQNQSQALIKLQ
>A0A4R0FXK6|diguanylate cyclase|EC 2.7.7.65|Enterobacter wuhouensis|TrEMBL
MNKDFTSTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDALAANETLATLGKQGQFAAAEVLNVNKKQFAYWSWNPEDNTDTLGALVS
RWLFPVPVTQPIMHNGNTIGEIRLTARDSLISHFIWMSFAVLTGCILFASAVALTITRSL
HHGMVTAMQNITDVVHDVRTNRNFSRRVKAGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLMRTAMHDPLTGLANRAAFRNSIAALMNDTSAKTNSALLFLDGDNFKLINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSEHEVKDICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASLEALLERADRNMYQVKNQRTKTIS
>A0A734F0V4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRIYAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>K9NDK5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MSDEAQRWKEKYLKSIEQQEKLERRWDARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRE
VVRTDDMDAGLAALIPRLEKAVLDSEQRRETRINQTSAALTALVTQLQTLPLPRDVSRPL
KSFARQLDARVSQAREMPLLLSELSGLQGKALSQLETPTEPGRPGLLQRLFGGREAEEAV
ASTTASPAPAAPDAIETVICEVPMAERVEEASAPAEPAEASPAPAVVALAPAAAEPQSAS
AGAAETGSTEKPTPETIETPLESQVNPDELIVPASPDGQALLATPTEEVVAADQSLSGHD
TFYALPDTPEPSYSSVASHIEHTLLGLLEDLTLPERHRPQAESMRDRLKNGLNWYELLPI
LDDFATLMLAITDSGQHEFEAYLQRLNERLESFQSNLQAATAGHADNRSAARQMDTQIRE
QVDGLQSSMQEAADLEGLKHVLENHLEGLLGTMDQHQKQRDEREQEVAARLHSLAERVAH
MEQEAQGYREHLEEQRQKALVDPLTGLPNRAAWSERLEHEVKQWQQHGNTLLLAMLDLDH
FKRINDNYGHLAGDKVLKIIASVLRKRLRATDFIARFGGEEFVLLMPSTVPAAGLKLLES
LRASIEACPFHFKGEPVTITVSVGMSAFRPGEHSDQVLKRADQALYRAKNAGRNRVEPG
>A0A375FBK7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MTRPIPTLHRLSARAWQRLASRPHRFVVVSFSLSVMLLVLLLWRGLQLSQGREIETLRHM
QAVRAQSMDALLQREAERLLSVRNFAEHLLQIQATAPARPDADLRAALARRDEPVWPVPA
HDAAAVYGVGAAALRGLEGFDRNDARLGADVIVARSLSHLLSAAPQGSGIRRRIAYVSRN
GVLTAYPSIPPQEVSSAVHRLAAAPYFLDSLPARNPGRRMQWRIAQATAERDQVSLFLSV
PVYAGGDLRGVAILELPQRSLDDQLGTAPFHQASSYLVDREGRLVGASTRNVRAGETMQT
ALSGPWPAATLNTVFHADSGLVSGGNGGGNDLMFRRLGNGGLALVDEIPVNQLWRASAAR
LSGVVGAGAAALGILLCATLAVVHSLFRHYLARGEALRTLAETDALTGLANRRVFAARFE
AESARCAAEQRPIAVVMLDIDHFKSINDRWGHASGDVVLRGVADALRGGVRQDDLPARLG
GEEFAVLLPGTGVDDAAAVAEHLRQRLEGLRCEPAPDAGSTEPIRFTASFGVAGAAPGDR
ANLDALLMAADRRLYEAKANGRNQVVAR
>K9NEP9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MNQTRTLGTPRLLGIVWPFIAVVLFQALLGGVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LNLYADSGDEGIFDKYQSAISVPQGGHELRVALDQQPPDIEAARLAILKGGNHPDDVSSL
IWLYLNFRHFSYLEKAIDLWTVGDAYLAKLDDVARDMHQHINTRPASDADIQRWKEQIFA
INDEVTPAAKAFSDALGEGSRVILRLLLLTNLATALGLIALALMRTRKLLKQRHAFADAL
QLEKERAQITLQSIGDGVITTDVSGAIAYMNPAAEALTHWKAEQATGLPLAALFNLLDEE
AQTDGFTLIEHILSGQLSGGSEHSKLIQRLDGSTVSVTLVGAPIRNAGKVSGTVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQALHNLTRYSGRHALMFLDLDQFKLVN
DTCGHAAGDELLRHICALLQSGLREGDTLARLGGDEFGILLENCAPEAAEKIAESLRQTV
QNLHFVWKGRPFVTTVSIGLVHVAQNPTTLEVSLRAADMACYMAKEKGRNRVQVYHPDDS
ELSLRFGEMAWVQRLHMALEENRFCLYAQEIVPLGHVEQDGGHIEILLRLHDEAGRMILP
DSFIPAAERYGLMSSLDRWVVQNVFKIIAQCRAERGQGPLAMCAINLSGTTIGDEAFLDF
LREQFVTYSIPPEMICFEITETSAISNLGSAIRFINELKGLGCHFSLDDFCAGMSSFAYL
KHLPVDFLKIDGSFVKDMLEDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALLEIG
VDYAQGYVIERPHLFTSDSLLSRPARPQPMLFKAPGTFR
>A0A399EJV6|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MPGEFVSWQEVRHSLLLRVALGILLLVIYAARPFSFNHPLMYGVFVIIIAQVITTAFGIP
RHWSWLPGVNFYLNRLALVLLLGATGGGSSPFVAVSYIALVAALIWYNTRRSVVILVGSH
WLALFAGAALAGEVGFPPTWSYCLLQAIGMAIIAHILSKPLSQLNHHAATDPLTHALNRR
GGFEVLETWIAQRQPFALIFIDLKGFKLINDTYGHAVGDEVLAWVAQVCRSTQRSGDLVI
RYGGDEFVLAVLGRPGSLIQRLEERLNAGFQSAAGHLSIQANLGVVHFPEDGRDLEQLIR
LADQHMYAHKGVDLATT
>A0A0S4RJ77|diguanylate cyclase|EC 2.7.7.65|Campylobacter fetus subsp. fetus|TrEMBL
MNQNNSDNITRNLQKIIDVFCIMSGVYIFIFFIRAQYDLLILSVFNIFIYMICLYLSRKD
SINNAFLLLHIQITLYISICIVKLGWNCGFDLIFIALLSIIYIDVFKNRSVSYLVASLES
ATYVLLYIFTFEDRNFHDTPLFLINFAFLMFLLLLLSKTLRITDIVHFHKLQNEENKFKN
MSQTDYLTGLLNKRALTSIMNETRYCDMIVAICDIDNFKKINDKYGHNVGDEILKRISDI
LTQNSAKSDIVSRWGGEEFFIVSFDTKKEIFLDKIEKMRRQAEKIRVNTPNGIVNCTLTF
GVSDRSDDKETLIKQADERLYKGKRSTKNCVVSSDDGSTPPTRLFR
>A0A375J0E1|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLTTLLDRLWEQAVRTPQRFVVLSFAVASMLLVLFFGYGLALLRDHQIQSLQQDQQL
QVAGISSVLNIEAERLMSVRAYAQHLIRLQSGPHAITPDPPLKAAYDHRNDAVWTLPAPE
GDAVLLGVGPAALAGMDGFSRRDTDLLAGLYVARGLSHLISAEPLNPLVSRKLTYVSTNG
FFVTYPPVPPADTAATLRRIAAAGYLREHRPEANPGQSVRWHFAPAADGAPDGTLSLSVP
VYLAQQFRGVAFTEIPQRSLDAYLTRTTRQAVQRFLVDVDGNLVGTSTRDVRRGEKLSEV
LPASWREASAREMFRRGSGTLQSADGSRILFQRIGNSSLALVDYFSATDLLLRVASHLSA
VLAASTLALALLMWVTLQGIGKLFSHYQARGEALRELAGTDALTGLANRREFKARFDIEY
QHSRRDQTPMSLLMIDIDRFKRINDHWGHASGDRVLTALAGVVRATVRAIDVPARVGGEE
FAVLLPRTALEEAARIAERLRKTIGQTACAPAADAADQEEIRFTVSIGVADMGVDGTDSL
DAMMQVADRRLYAAKAAGRNRVVSDDRVAEPAAAQTQEGPVVASHIGN
>A0A378KPW4|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MTGALSRVTMLSTLREQQEIIKRQGQSCCLVMVDLDYFKEINDRHGHQMGDRVLATAVRL
FIENLRAYDKVFRYGGEEFLLCLPFTDLDMGFAMSERLRKVLEAITIDDGKEHLIQVTAS
FGLALLEPNKPIEESIEHADKALYLAKSEGRNRVRVWK
>A0A2X4XA77|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MYAPSVIDTRRSGLSFARRTYLPRIVGLGIGFLCVFSVLHSQPSAPWVWGLLIFHGFIWP
HVAYQWARRSATPFKAETRNLLIDSFFGGLWAAMMAFNALPSVVILSMMGMNNIAAAGKT
LFFKGLVAQLAGALTVSALLGFPFQPQSTPLQIYLCLPMIYLYPALLGLVTYRTAKRLAQ
KKQELLRISMRDGLTGLYNRRHWEHLLHHQFDSCRRYQHTATLILMDVDRFKTINDTFGH
ALGDEVLAVLAEELLIGLRAVDIVGRYGGDEFGAVLPNTSAEQASIALQRIQERLNDIIF
REAPQLRLNISAGIADYHGEMGGYLDWLKAADNALYRAKNNGRNRLELAVPGN
>A0A4U6MW14|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. TBCS-14|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRNLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A4U6MP93|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. TBCS-14|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQHHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVEVMKTHPAQAIPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>W7NU01|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWAFVWPHFAWQLSCRATSPHQQETFNLKIDAIIAGLWIGVMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPLVGKVAVFNPDPLEWGLTLPVLVFY
PMLFAWLSHRTAVRLAEHKLRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIIAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLENLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
GRTEVAA
>A0A399F408|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MTELPALALALLGVVSGVVLWVRSRGEPAWRGAALGTLAWGLSAASRGLEPSPLPGLPDG
LLGLGVLGWLWSLYILEPKALPQRALGPLPALLVMAYAAVSWPHISLHTLVSLAALLPPL
LALPALEAALRGTASEARVSWSLGLLLMAAGTLAPVGLGTPLTLFTPFTLGLGFILVGWG
GWLEGRSQHLPKELLGFMNLGLVLALVLLALDSPEVKAAPWALATFAYLMVVALAWMGLA
VYTRIQRAECGLERWIGLLQGLSSNTSTQILSLQGVMQSVLEGLKPLFPNLLGLEIRTDI
VQRVGHSGPYVYNFELFLDNPAEGRLYFSSPPQDERGLGALAPILTERLRLSLTLSEWRS
KAYTDPLTGLLNRRGYERSMNRLIRLSQETQKPITLALLDLDHFKRVNDSFGHAAGDEVL
KSLAKLLRTISRADDLAVRLGGEEFCLVLFGAGLEDAGRMLERVRLEFKKLQIPQVEGAL
SLSGGMAGGEIPTSMATVNRWLEQADSALYDAKQAGRDRIYSATPPTLRPFGR
>A0A3S4EUA0|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAVADTLATLGRQGQFAAAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSQPIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
NGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFAQDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGKSLSDLPTRRR
>A0A1H6FC68|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MPRFTTKLFTDLAIWMIIFGLLTGISFPFFALWLGLPAQQILTPKFWMATLGAGLLLGTI
NYMLARRVVRPRLQLLANHMHVVESTIRDATFSGNWRHCSTEHCRVAVDSNDEIGESARA
FNDLVEALFRSKEVEQAVSDFSKTLSSQLELDLLSSQALEMLLQHTNALAGALLIEKSGR
MEVVAQHGLDNPAALADSDYVRKAMRTRKTQCVEFPEGVQVEAVMARFCPKEIIVTSVEF
KENSLGVIILASNQAFNPEVSWLLELFRQGFGLALNNALIHAHLQHIAALDALTGAYNRR
FGMARLHEEFNRSNRSSAPLGLIMVDLDHFKHINDTYGHLIGDRVLHLTSDSIRNSLRGG
DLMIRYGGEEFLVVLPAAKLKEATDIAERIRCIIAKLNVQDGEQTVRLTASFGVSAYPED
NAIDIEELISHVDTALYQAKAQGRNQVVIANTNPGST
>B7L7I9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain 55989 / EAEC)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4D8QYQ1|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTNSSDTRSPSDSLGLVLDEHLRWIGQWHRAVFFRGGEGGERVSAPASFAAWCVAVNADD
LAHQPAVEKLVTLHEQMHRKAKLLLLKAADGESPSEADYEGVIARFEEFVLHLRRVERAF
GAAASGLDPLTGLRTRRGMQEALEREHNRFRRNGPAFCVAICDIDRFKGINDTYGHDIGD
RVLAATAAAISRGIRSFDEAFRMGGEEFLICLKETGLAEGFRVIERLRGELARTPVTLPD
GRRIAVTASFGLVEAGEDLPVEEMVVCADRALYQAKNSGRNRVVRYGLDQPEVAAERSAL
PNRR
>A0A2X3J0C7|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MTPLRPSGGWQSTIINFSNMVFIVTAARLLLRYSRNMDESNWALNAFNIFNFSLIAAILS
SLFGAVGSLGISGDYHEKFMPLYADWVSEQFSTGVLMLPCLLTASWPSWRKLSGIVPSDM
YPFFSVVIAVCTAMIIGGAGSLAFPLPALIWCAIRYPLPVTALLTLITGGVEIVLVAHAA
INLHSEQPLLLVDQMFSARLGIATIAICPLIVSISVDAINQLIKQTSLRADYDYLTGVYS
RSGLFEALKRSGRHQPTPQEPLLCVMLLDIDFFKRINDSWGHECGDAVLASFASRVLDTV
GDRGMVARIGGEEFVVVCRVRDNAQGFEIAEQIRKTIELSTFRYEEHSLFITVSIGLAEA
ALGSNSLEATFNQLIPEADKCLYLSKRQGRNKTSASGGAPEASPASQISDS
>A0A7W8HUP4|diguanylate cyclase|EC 2.7.7.65|Rhizobium rosettiformans|TrEMBL
MTARILVVDDIPANVKLLEARLMAEYFDVLTASNGRDALDICDRTQVDVILLDIMMPEMD
GFEVCERLKSNPRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLISRVKSLV
RLKTLTDELRIRHDSTRQAGLDDMLRLQDGRLEEQAHVLLVDSRGASQERIIKALKPIAE
VSAMSDPQAAVFEAAENSFDLVIVNGNLEDYDPLRLCSQIRSLERTRFIPILLITEQGDE
QMIIRALDLGVNDYIVRPLDPNELIARSLTQVRRKRYNDRLRNSVRQTIELAVTDALTGL
HNRRYLDTHLRTLFARAKVRGRPLTICITDIDRFKQVNDVYGHDAGDEVLKEFAGRIRST
VRGADLACRFGGEEFVVVMPDTPAEAAAAVAERLRGMIEARPFQLRSGETPLMLTASMGI
ATLMPGIDTPEQLLKQADRALYEAKNSGRNRVVAAAA
>A0A235H9U9|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALADADAISDVFYAILLDRPDSNSFL
SHALVQERLRPSLARWIAALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRII
KKELSARLLAADLSRAQTASAILFISELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDNNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTGRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEASLRVKADQLRRTVEEHRFNSAGGAGKGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A3P8L9I0|diguanylate cyclase|EC 2.7.7.65|Tsukamurella paurometabola|TrEMBL
MSAEPDPPVSAGPVAKRATARRLVRRVRRELTDGRAWRTAGTAEYAYTTEAIRFLRGEWA
LRVSIAFLAMMMLPLALVMQFNPMGPHGVLPRTIHLGAAVIGFVLGIRWVVGAWPTVREA
VWFLLGADALIGIAVSVLSEPTARICGAIHLAMLGMFAAFLLGWRILLVHCVYSLVLIAG
LTGYSILAEGRSLLDLYVYTTPAITTVVGLPVVIQVVVETGRYGITRVSREWYTDVLTGV
HNRRGMSFAVRRAALRVGSDDIMLVGALDLDDFKRYNDSHGHTAGDELLVDVARRLMAVP
RLVVGRNGGDEFGLFAVRADRDDAARVLEELRDLVQRHGDGDRRIRGSLGVVIARGRDRD
RLGELAVEADEALYQAKRSPTTAVVVRNPLML
>A0A151AW13|diguanylate cyclase|EC 2.7.7.65|Moorella mulderi DSM 14980|TrEMBL
MPTVEGLISQKLYTIDPLASVGRAASIMERYGIGSLPVVEEGKLVGIITSRDIKRSHPNR
LVADAMTRKVITVPPTACLTEAQKLMAKYKIERLVVTRESDIIGIVTFAQIMSELGKYTD
SLTGLNKAEIFYEKALELLKEGQEIAVIFLDLDNFGFINKEYGHIYGDNVLRQTALILNS
LIDSNKDTLCRYAGDEFAAVTTRPLAEAEKLARQMVLALTNKNWPGKIKVAISAGVAGGR
CSELRSSGEDSSYIVKYLVNTASLASTRAKKVKKPVVAVEAIEFKETVGM
>A0A151ASH6|diguanylate cyclase|EC 2.7.7.65|Moorella mulderi DSM 14980|TrEMBL
MSLEQAKTLSEFCKTVIYFLSALGMEICLHKGRNRKGRGPEKLLVLGLLTMGTGTFLSAY
GVKLGLPESWGKILGDLVLVNAGTAVTILAVYLLTLKFHLVALALKKEAVTDPLTGLYNR
RTFFRELDCRLERGGSLAVAVLDLDNMKQINDTLGHQIGDEVLRAAARALKKTTREKDIA
ARYGGDEFVVLFASEGPRVEKFKARLKENLMAELPYTGEIEVGISTGVAYCPEDGEDARS
LLSAADARMYAEKEAKKNHYYAFGLLAENSKPLEVGITRKRPFTLVEGRRELF
>A0A1R7QHE1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MFRKSSNTSLQKIFSQSQLLIFALTLGICSLIFVVISIYTMNTYAKQSLNIFSATLSEQI
QPAVIFNDSITLQQTLNNHIQQYPIRAIQVINLQGKPLAEAYKPTPEFAWMENLFDKVFF
KHPVTRTIKHQNNQYGSLIIYGSATQLMSFFFQLLICLSAGIFVILLIMLWLVHSTYQKL
MHSIQPMVNTVESLNLDTQYQARLPSSPIYEFRVISGAFNNLLDKVQRTNEKLQSENSQL
SHQALHDQLTELPNRHYFYNILFNQFEHPEKNQTALFFIDNNNFKNINDVYGHLAGDAVL
KEMAQRLKKNVRSHDVVARLGGDEFAILIRNIKHYDHLELICEHLIECSKAPLSFDQQQI
HFSFSIGVAFSKCATTPEDLIAEADNAMYKAKNLAQGWYITPCLNPDQEPSC
>A0A735HQB7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 47:b:1,5|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1A8TQ40|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MIQYLMSSYLGINKQDEHYRHVSLVLIYAISCVCVTTFYCFYNTLIFDYPKMFLIDLAGT
IVGLLALYVLLGLKRIRLASWILLLMAAGVVLAVILSRVNANYSMAWAMIIPLMSVFLLG
YLWGTVFSLGYLALVVWIARQGLETWQAAPWDVGSAVNVVAIYLLLFMLSCYFEASRRSA
HKLLQASNQKLAHLASTDVLTGLKNRRSIEDYLLAHDRQPLFLAMIDVDDFKHINDDFGH
NTGDEVLVALAQLMQQLVGDHGVVGRWGGEEFVIVFDDSNVEAFEALLIQLVQGVAATGF
GVSRSVTISVGGSRHTGADHKLTLRAADEALYEVKQKGKNGYKIAMASA
>A0A0Q0HWX1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MIRILCLLLFATNVTAKDVQSEISRALHGYTTYSESVEILARLEKQMPYENVLDDAQVMA
FKCWFSNLSTPNGINEYKKFLETAKPIIQQVNNLNLIQELAVCEANQEYTQGNYQKALEH
LKPIINTPSVDEITSSKKLSIIALAHIVLNRIQLTKGDYQEAFDSAKTAYQLFEKAGNDY
EKALALKEIADIHIALYNYELAIEQLQRAKLALTKFNEQEQYKVADQLAYAYEEKGDLIK
AVELYESIKKDVRRFESENGYAYILIKLTELNIKLNSLSQGESYLTELNTLSVTDSWILT
LYNFTKSEWYLATYQLQAALTSYEKIAGQQQYWPESLKERYLNLTSQLAAATGDTSLQIT
SQQQLIALIKDKQQAIANNTLISARLNFNYEQQILEISRLEHESKLQQKFLAVAEDKSFW
QGLTVMVTCLCLLLFAVYTFKQVRQKKYFEILALKDELTGIANRRAILNLKRSVMVQNKL
NQQVSSLISIDIDHFKAVNDQYGHDIGDELIISITNTIVQTVRCSDRVGRVGGEEFLIVL
ENQSLEHAKDIAERIRLSVAEKEHTSLSISATISLGVIEIAPNETSEQAAKRVDLHLYEA
KRRGRNIVFS
>A0A0P9FUE1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MPLIVFLFCVLFAAALDATETEQATQQNISAHIQKQSNLTFSNYENRIEQLSLKHNQDNL
EMLAALNQFNEQNPTNNLNDLAYLLSYRCYLELVNNQQDAYQQTEQSLLALTISSASDPA
ISAATSFCKSWRYYFEKDAKQYDLYIEQSFNYALNTQTPVLKYWIAISFAMMAQDTGRNS
AAIEAAKLAMTIANVNKDNYREATSRAIIAISEAELGFFDDALINNQWAIDWYKSVDQQN
AILGLYQNRGFILNSQGNTAQAKAIYLDAIEQAKKLENQDAIHEIYSNLAAIAFTEGELA
LSNDYAEKTLQYAQQSDYQTLAAHAYSIMAINNVYLNQLDLAQEYFDKGNSYFEEYKMIS
LLADNYKSWSEAMASIENFEAAYKAQLRYKELSDKIFNTERESRMLRIKELYEVAQKDQE
IEQLAFDNQRKNTEIENKSLQKRIWVLSAVITLLAFIILSFFYRKLNTSNKKLTKHNTKL
NEERFIDPLTEGLNRRFFEVQQRERMLNVPEVSFSLFALDIDHFKSLNDTHGHACGDQVL
KQFCQRIRQSIRQQDNLIRMGGEEFLLVIENSNLEADAQLIKKLLAITNSEPITFEQHNV
SISVSIGAASNVNIYDETTLDFALELADQALYKAKQAGRNQGELLDLYQINLASVINNYD
MIVSKTVTSRTQQ
>A0A2X2GLK5|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MNARISDRHGLPVAIPLITLFLLAFLLSLLGIFTRPIGSLSLFWPVNAILLGLLLRKPAY
ATPAGWLITYIGMIAADLANGESLSLAMWLNACNMSLIATGYGVMLLLPKSQRRMGKPQT
ILYMFTASLSSAAVASTLSILRSESLYNNTAVIAWLAWFSEQFSTNLLLLPVLLAAPRLK
QLLRMQINWQLRASMPLLALLFSLVFSVYIGGPGAIAFPIPALLWCAVRYQLFTVTLLTL
LTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAVNRKLLRR
LEHSANHDFLTGVLARNALTRKAGELLEHKHKSKEAVSLLLIDIDHFKQINDTHGHLVGD
QVLASFAHIVRRELRHDQLFGRLGGEEFAIILPRALAAQGVALAEHLRQLVQKADLHPGG
KALLNITISVGVASLAMNEVKSWEQLMNMADIALYRAKSQGRNRVESFNVVSGNSVGHIM
FK
>A0A0P9G8B2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MLVFLLLFLSFSANAQITVNQDPIALTQFDTHFYIDGSRTQSIADIQNVPFSRATNRLTF
GTNAKTTWVRFALHNSSASEKQLFLHVPEAYHTQQLTLYLIRDSNTQIRHSIDLENNQAH
EMLYGGTAVFPLILSPNERYQVYFKSDVFSHQWFTLALYDETQSKHALVSENHDIAIMVG
MLLALMFYNVILFLSSRKTENIFYALYLVSGTTWIALSYGFLATLFGIYGKAMMHLHLSL
LTMPSFLILFMVSIFETKRLYPTEHKALMFVLLLLVSDLVFGVFDIITALKPASTLAAIM
IVVTLSVSLSILKKGNPLAKYFLFGHGLFFTFNLLAIGYYKGLLPNTYVTSHGVGIGIML
ESFVLAFIISYRIRVLERIEKQQAALQVQANTDPLTQLYNRRYFDQATEAVLADATQNYP
VSIAIADIDFFKKFNDKYGHQVGDEVLVVFADILQKFTPDNAIVARLGGEEFIIALPNHS
EKQAFDLINKVRMQIENTTISSYTHDALSITASFGVCEIESLLKPSIINADKALYRAKEN
GRNLVMPFSTLNEPRLSLQTQ
>A0A5P3VRZ3|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MRPRLSALLDHLWEQAVRTPQRFVVLSFAAAAVLLLVISAHGLVVLRDHEVQTLQQTQQL
QVAGISSVLNVETERLRSVRNFAQHLIRLQMGPHAVEADPPLQAAYAHRNDDLWQLPAPE
GDAVLLGVGPRMLEGMDSFYRRDEDLLPGLYVARGISHLLSAEPVNPLVTRKLMYVSSNG
FFVAYPPVPPARTAAVLRRVDDAGFLREHLPHNNPDRTLRWQMMPAGDGSGDVYLTVSLP
VYLHAQFRGVAISGISQRSLDAYLTNTTRKGVRSFLIDIDGRLVGASTRDVRSVEKFAAA
VPSASGEATPHEMFRRGSGTLHLADGSRLMFQRIGSTNLMLVDYFSATDLLLRTASHLSV
VLAASALSLAVLLWVTLQGFRKLFSHYQARGEALRELAETDALTGLANRRVFEARFAVEH
SHSLREKTPMSMLMIDIDRFKRINDNWGHASGDRVLKTLADVMRATVRAIDVPARIGGEE
FAVLLPRTSIEEATQTAERLRKILGQTVCGPAADAADMGDIQFTVSIGVSDLGADGTDNL
DTMLMVADRRLYAAKNAGRNRVVSDDRVPEPAGEVLSGGPRW
>A0A0P9GBQ4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MSVDFELNEIHWMMDMFNTIDVGLVVLDRKYNICVWNGFMEAHSGLLPSAVKGKDVFDAF
PGIDEPWFRSKAESVFVLKTRSFTIWEQHPYIFKFKNYRPITGKADYMYQNGTLIPLTNT
TGEVSHLCVIIYDVTDEAVNKLELEQANAKLEELSRVDRLTNLYNRGFWEESFSKEFKRQ
QRSQAKSCLLMFDIDHFKKINDLFGHQGGDAALCFVSQTLKKVLRESDVAGRYGGEEFAV
TLVDTDLDGAKVFAERLRKTIEDAVIHYEESEITLTISIGIAQFDGKYTKYEQWIEDADK
ALYRSKEAGRNTINVA
>A0A1C3IWP8|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MRFSLFLIVMCWSAFVSAQTKDVLVIHSYHQGFFWTDDFHKGLSEELDRDRLSYRVVYLD
SKRTQNPEYLERVYQLYHTKLMHEEFAAVVVSDNNALNLMKRLAPDLKDTPVIFGGINNF
SPEMIEGLNATGITEDIDLLGNIELIKRLQTNVKKIYIVTDHSVTGEAIRSQIDRSIEAH
PNFSDLLEHYVPDSYQELIAFSQRTDLDQSLLFWAYYRDAKGNVSSVEDWRQLNIKTQMP
LYMVHDLGLGFGAIGGVIQSGETQGRDTGRVLLKVLANPNEPLPLVAPGASEIKLDYQQM
SRWGLGTENEASITFLNKPQSFLVRYHDEIRTIGLLFLVMSCVIATLVYYLNRLKKSERA
SRQSQLLLESIFDQSLQFMGILDKGGVLLSSNSKLHELLYNQGYKLGTPLQEYWEGAAGE
VLKEYFAERDDYPTLRFEAEVWCRDRGGMVLDISLKPMPISEEDTIQFLFEARDVTSRKL
AENKLFQREANLKLYYDKQPVMMITLDVNNRIQQVNQFAEELLGYPLDLLLGHRPREFYV
DENAMIPRHILLQPQHKIRGVWRRDIEYRHADGRTIWIRENIRPLVDSGQLLIVGEDITE
TRELSEKLEYQARYDLLTDTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLNDT
AGHEAGDAAILFSANLIEDVLPYNAVLARMGGDEFAVLIKDCTERDAVNVCHSIISMMSE
NPFLWGDIHLNLTCSIGIRLIDHTAASSQMVHAQADAACHAAKEEGRNRYHLYHLDDEDL
RRRHLEMECVNLVHEALANDRLELFAQRILGLEENSNKMHFEILVRIKNVQGEYISPGIF
MPASERYNIAHLIDRQVVSQTLNWLEQRPHLVDDLGMCSINLSGHSMGNREFVEFLIESL
ANSSVPCHKICLEITETAAMSNMKQAIKFFTRIKELGCLIALDDFGSGLSSFGYLKALPV
DIVKIDGLFVRDIDVNEMDYVMVRSINDLAKQMGKHTVAEFVENTQVLDKLIELGVNYAQ
GYVIGRPKPLAELVEELRQEREIE
>A0A8B5QF05|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls712|TrEMBL
MDKGHSPVTRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKHQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISRFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGNRHSPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFDRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKNLRSERTIIK
>A0A1C3IFG2|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MKVNRHFSLTFVFGFPAVIATMLLGLIGKNHFDAVEKDISSEFQRIEEVFKRTTKIVTAL
DYSFSNYYKSGNPLFLDHNKQVVDGICRIWPIDVLLLADGKTADIPSVDIDYMLVGQESL
CNETSDSYKSASEKIALAPILSFLSQLDEYHNGVHFIDTRGYVISSPEDFAKELGKELLS
TIKSRPYWQRTANNPEQLTLTGPAYRFDSLDRMISMTIPVFHKGIHQGMLSVEIDASKLL
ASSNEHLAGRIDIIDTTLVNPVDNATFYHAIQLEGVTSHHAMYYEFDFAKEVEHFFVYEK
DSLIVAIIVYLFSVTLFFFVNSNIERGYFKELAAKDPMTGLLNRRGLEAFWRSVEHDQLF
ALTVFDIDNFKLINDTFGHDKGDDVIRYMSRQISNSIRSSDVAARFGGEEFVVYLKGDDR
ETLMRTLERVKNAVCANSANIVPNGFTVSGGVCITEAEHNNLSFEEIFKHADEKLYVAKT
TGKDRIVF
>A0A7W3D3R2|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLALLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A7D6WPA8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEEQAFRAGLVDPALSKALDRRVFSEFFQNSAQAVASKGLSIALPLSAVGLLNTELI
DELLEHLQRSPLPPRLLHLTVPASVFKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGVDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A1V6I9Z2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin026|TrEMBL
MDDNIQNRFDVSILYVENESASRKKFSEITGKLINKLYLAKDGNEGLALFKEYKPEIVVT
NITLPYTNGIEMVRKMKAMQDDLPVIMTLARNDLNYLIDTFGSDISYYLLKPLDSKTLFN
AIKRCAEAIAYRRQLAQQDKHIKELSLAVEFSPDIIIITNTDGIIEYINPKFIEITGYSK
EEIIGKTLDILKGSDVDLNTYSSFLSSLKTGKEWRGRLINKKKNDECYWASTSLFPVKQQ
ITDKVEHFICIQEDITDWKLTEEDLRISEETFKVLTMLAQDAIVMVDETGIINFWNEAAE
KMFLLESRNAVGKTLWDFIPSYVVKEIFESEIKHYKETCQCSVSGNILEDMAKKIDGTVF
PIEISVTAIQIRDKCHSIAIIRDITERKRVEQVVLNEKAKFQTLSENAPFGIMLVDEKGT
LLYVNPVFIEMFGYNHEEIPDGKTWFKKAFPEKDYRHEITENWIKDIEEPNAGKREPWVL
TVTCKDKTQKTVDFYPVKLNSGESIVFCQDLTELKKNERKLLYITNYDALTGLPNRHSME
ETLRQTIEVAKKGRKRGGLSALLFLDIYGFGDINAKLGPTSGDELLISTGKMLKNSLRGG
DTVYRFGGDEFAIIFKGISMAEARLAAERIQRTINQHKFSIEYEKYNMYLSMGIIQIDGT
MDMVTLLSKALNALYKAKKLGKNQIVVYQEE
>A0A351NM36|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium|TrEMBL
MPPSTAATGSPRLNRIRTYLVPARVVNLCFLIVLVSSTLLTWREVAVLEDAYVASQRNTL
DKVSSTLDRQMEIGVNALLFFRNAMRAAVQTPLASDVLKNVQAEFAQQRQLPVWRISVDQ
RRTLPITGVSDAFVARHPLLSRDDPQMHNEMTAALEVGYIMRLATAIPAMPKHAWYVSRA
GFYLSSRPTAVSAESITRYESLLAQPWFTGQSIHDNRFRGIRWFTSQHPADLQEPIVTVS
VPLDYAQYWYGVLAIDYAYSSVKQLLAEALRDEEQGEYQLYNNNLERVVTSLPAGVQPRN
FTQAQREMLTQAITLSNSGSLRLGPNFVVWQKLDHFDGMLLRIQTLREGLQGDFGTISIV
LALLWLLFTAMVLCSWVVIRRMVSNMYAMQHSLQWQAWHDPLTRLLNRGALFERAKALAE
LCQQQHRPFSVIQLDLDHFKNVNDHYGHQAGDLVLTQAARLIGGCIQGEDLAGRVGGEEF
CIVLPGSTLLQAQRVAERVRERISRKEILVHNSQTIRISASLGVSSAEPSESYVFEYLQM
VADKRLYLAKWGGRNRVCAVDPIQDAPNT
>A0A449BKB7|diguanylate cyclase|EC 2.7.7.65|Acholeplasma hippikon|TrEMBL
MKRSSTTDQIVHTKLYKTALFIGLILSVIAITGNFMGGLPIVENIKWLVLLITCTVSLAL
FENNRAKETTKFILFFIIIWIFIPLGFIETGSSKNVTFSYLMLTVILVSLLFSGVKRIFF
LASLLTVFVILHFLDYHFKMPTDLFTDESYFLDQLIQIPFIMLSAIYILIQYANEYAKLN
QRLDDQANIDVLTTLYNRRGFNKAIQDIVKYNITNAQLGFIDIDNFKQLNDSYGHSIGDE
ALRVLSNFMRQAINPSQHILARWGGDEFAIIYYGNKSCLEAHLENIKNQFINYAANYLPV
VNISMSVISFSDYNSLEEAITAADKLLYKDKYLKNK
>F7S6J4|diguanylate cyclase|EC 2.7.7.65|Acidiphilium sp. PM|TrEMBL
MSLGRGMTESTAFYRERRAPLPPFSAILGTDQAERLAIGLTLISMALYLFCLVAEWIGVS
LNLVDATQSLWLTIVALGGEVAFYVLLRSGISRRWPDPTLSLPQMVFAITLLGAAYLINP
QVRGELLMLAALVLEFGAFQLPPRRCRDLGWFAVAVFGVAMAIGATVSPDRFDPRIEVFQ
FALMLAFLPVIAGIAGKLSQMRLDQKQQRRQLRDALKQVQILATRDELTGLPNRRHALEL
IERETARARRSGAPLCVAILDLDHFKRINDTFGHGVGDEVLRTFGREGRLVLRADNIFAR
WGGEEFILVMPDSTLIDAQTIVRRLREHMASPECWASCLRARTTFSAGIAEFLVGETLDE
TFIRADAALYEAKKLGRDLTMTA
>A0A1V4VEE4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin104|TrEMBL
MFWLILLLFNVCSGVLIGTLVKKLYHGVSKDPLTGLYNRRCFYDRIDYEIEKMKRTKLPL
SFALIDIDNFKTINDTYGHLEGDKVLVELARIFKTQARSGDTIVRWGGEEFAMILPETDK
SGVLAFAERIRKLVEFSNCKYKITVCIGITTVYQEHDAEKIMSVADRALYKAKEKKNTVV
YGVFNNITT
>A0A518AJL8|diguanylate cyclase|EC 2.7.7.65|Aeoliella mucimassa|TrEMBL
MIEPTPLKPIAPDERQAQEVPTVPVNHRVSEVLQRLGQAAQEDGLMSSGEASSERRFQRQ
LVKSRLGSAAGLFTALRCKHASTASHSLRVALVCSGWAASTDMTSEQRETLEVAALLHDI
GKIGVPDSIIMKPGRLEPEEAAAMAGCRQLAVEMLTTTGAPQFVLDTILTAAAWFDGSNK
ELPLAGDQIPQAARMLAIVDAFDSMTTDHVYRRARSRERAVAELFDFAGRQFDHKLVKSF
AELISRDQRVLSDQVASQWLAELSHLSTSWETYPTTATTRPGDRRQRGTNTLFEQKLVEN
MHDGVVFVNNQQQIFMWNTGAERLTGIAGAAVCGRNFQPSLLQMSDQKGSLIDDDDCPVS
KSIASGIQVLERVGVLGRSGRHVTIDLHVIPVYDDNRKACGATILLHDASSETTLEERCQ
ALHAQMIRDPLTQVANRAEFDRMLSLFVEAHQDTELTCSLIMADIDHFKYINDTFGHQAG
DEAIVNFASLLKSMCRSGDLVARYGGEEFTVLCADCDNATAASRAEAMRKKLSETTHEKL
ANHTVTASFGVTELQPGDTPESMLRRSDRALLQAKDQGRNQVVQLGAGMPEEPPKNRWFT
FKPWKGNALIDTALVTNVPVDIAIEKLRGFISDRKARIVLVTEDQVKLEVTETAQGKLGP
QRVPYVVEVQFSQQRQAKTNSSNLAGGEYAATLANVKIRPKRERDRRRSLVAERARLLLG
SLRSYLMAKEQNTELEPQEL
>A0A518AMX1|diguanylate cyclase|EC 2.7.7.65|Aeoliella mucimassa|TrEMBL
MSNSPESAFIQLRPLFDLLRCPCAEISTNTLECEWSNNAWKNLDIQLQDEGSGDTPLIDQ
LSNQLINFGTGTGTFSCQIAHPNGTVAEYETSVQHSAPSKERSSWMVILTPTGQTQGDQA
PEDRDTLTGLPGRATLMARLETYFDSTTLSPPFGLIFLDLDDFKQINDSNGHLLGDQVLQ
EVASRLSDALRTDDLIVRYGGDEFVAIVVGVAENNELKQVVRRLEDSLNAPFMVAGEKVR
LSISLGVAQSGENWATPMQMIDQADRRMYQAKQQRSGNQDL
>A0A6N2VPE4|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MNILVNLLVALEMLTVNMNVVNLCCTRKYSLIKTVFVIAVFSLFLVTVSYAVLSRGKNFG
NGNGMFALIGAMYVFPLKYLYAEPWKRIISIACSSWIYTMLIFSVSVHAVKIFQTENFAG
TVLAVQTLLYFITSVFFVSWIREKLVRALKFMEDGTKNIFLIFSLSWFLTMVLFNVQFTY
PQNRILKVICLLVLALNVTLNFIIIYYLVVNYKNINDLKEIAYMDSLTGLKNRNSLFHDA
QELIRKNQRFYLIFIDLDCFKQVNDLYGHLAGDEYLCVFAGKTEKFLKNQGMLYRMSGDE
FICLFMEKDPEEFLEKLSHLSFSVTDCYIPFKGCSAGSAVFPDDCLSLDKLISLADKKMY
RKKNKKHSC
>Q1LM75|diguanylate cyclase|EC 2.7.7.65|Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)|TrEMBL
MHSASDTGQLVPSDRFLSRLWLALIRRPRRFILIAFSAAILLILLLIFRGMMLSRDAEIE
SVRQMQAVRAVSINALLQLEAERLTNIRNYAEHLMQIQDELPALFAHDIQTAFEHRNDDV
WALRTRDAAPVFGVSAAQLTGLDGFLRDDAKLIPSMAVAIALSHMFSAGHNEPGLRERIA
YVSGNGIIVAYPAISEQDVNPTLRSLASAAYFRNNLPLANPTRKQQWSIARSMDDIGESS
LFLSAPVYAGNAFKAVLILEIPRHSLDESLNVAPHHDVNNYLVDHNGALVGASMRNVHRG
ESLASVLINKWPADKLAVAFRSDAGILSNEHGSRLIYRKLGNSGLIMVDEVSTRELLQAS
VARLSGAIGAGAVALGLLLCFTLAIVHTLFGHYIARGEALRTLAETDALTGLANRRVFAS
RFADAYAWCKRDAVPVSLIMLDIDRFKKINDRWGHASGDVVLRTLADALRANVRNVDLPA
RLGGEEFAVLLPRTGIADAANLAEKLRLALQALVCEPVDSDDTASIRFTASFGVAQIAPD
EPGNLDSLLMVADQRLYAAKAGGRNKVVWDEPQPEEMANEKPVKGT
>A0A8F7QBI3|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MPLDVSPPSVQPPSVWHGQAALSASILVACLLGIYSRPLGFMAAFWPANAILLGLLLRHP
ELARRPGSWLCALLAYVAADLLTGSTLFTALTLNLANLIGVLVGWLFLARVRNQVLGFKH
QRSVMTVFLACLLASVVCTLAGAWPSAIAFHLPLWQSALLWLSAEFYNYVLILPVFLAAP
SGWPWTWQLPKQQHSWNDALPLLALILSEAFSQLIGGHGAMAFSMPAMVWCAMSYGVFPI
TVLSLLVCLWKTGLLAVSSFDFVPEHLDDVLSYRTGLAMLSLAPLAVACAYTLRMQALQK
LHHAVHHDSLTGVLARSALLERGQKLLSRLEEEGQSVAVLMLDLDHFKQVNDHYGHAQGD
VVLQTFAQLASEALRPDDLLGRLGGEEFAILLPRTQREQALAVGQRICERLRDYRFPLED
GAPFQVTLSIGLHAVMSIGKQDSIEQLLSKADAALYLAKRSGRNQVRQYGPELAPSSI
>A0A653ZLP9|diguanylate cyclase|EC 2.7.7.65|Enterobacterales bacterium 8AC|TrEMBL
MPIAPLIATTTATTRRSGLGFAKRTYLPRIVGLAIGSLCVLAAIFPLHPPFAVWLLLAFN
GFVWPHIAYQWSIRSDKPFATEIRNLLIDALMGGAWVAAMGFNALPAVVILSMMGMNNIA
SGGLPLFFKGLAAQIIGAVLTSAVLDFPFYPQTTPQQLYLCLPMIFIYPTFLGFVTYRTA
KHLAEKKRELLRISMRDGLTGLYNRRHWEHLLHNEFDGCQRYGRKATLILMDIDHFKTIN
DTFGHALGDEALIVLAEELLLGLRVVDIVGRYGGDEFGAVLPNTSAEQASQALKRIQESL
NAIAFREAPELKLHISAGIAEYQPGMRGYQEWLKAADGALYRAKNNGRNRQELAIPQP
>A0A0Q0GM52|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MSTDQNAMNELHWLIDMVQTIEVGLVVLDRNYNIQLWNGFMENHSGVSPNGIKGKNLFDT
FSDLPKEWLTQKMESVFLLKNRSFISWEQRPYVFEFKNYRPITGRADHMYQNITLLPLAS
LTGNITHISIIIYDVTDVAINKLQLKSANEQLEKLSQTDSLTQLFNRRHWQACFEKEYER
YARYGESGSMIMIDIDNFKQINDKYGHPAGDKVIQSIAHILKQSLRETDFAGRYGGEEFA
VVLTNTNADESKYFTERLRKKVEASQVVYKNQIIKVTISIGVNALSEQTKNSASWLAGAD
KALYQSKENGRNQTSVFKEES
>A0A6N2S3S3|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKQNKWKHLKFEKYVFVLLLAIELIMSFTFLGFIHIDPISLTTAYIPIVVAGCLLGPLES
TLIGLVFGLASMYKASALYVVSDDKIFSPLYSGNPIGSILLSVGSRVLFGFVIGYLFSII
KGRRYEKIGIWILSLISQWIHAFLVFTVMGACFPQLGYTGMSTFHMGINDALIALCCLFW
VEVAYKIYHKERIQKYKDAVNQSLDDPYLSSKIVAISSGISFLIICIAIFSTGYFANRST
YMLKQHRVHVTRTIEIDLLHLQVQFLIAMLALDFILILTMLMIYQYMKYREYQGEIDFLT
GVMGRRLFLQHCQNIQSDQRIHGHQGWFLFLDVDWFKQINDKLGHIAGDETLKKFAMFLK
EQFEPYGAVGRVGGDEFAVMIEEEMSQEALEEEMKQFFQNISGIQKEVTVSCSIGVYRFK
YPKTIKELLTKTDEILYEAKANGRGCFVIR
>A0A2K9JZS5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MLQSRLNGVKIHSNFSGKLTLLLAVIYGAVFLFSPSIFALDDNCSLTTAHDDSILLTINT
TSYSKIERGNNTVSIACNLHEDSVFSFVDVGLNHYQWRVNAPLPVKFSQPAFIIPKGKYT
ATLSLDSMQIHTPRFGLMSMGKFIWESQKSSLVMGAFYGLCFTLICYVLIMGSRLNDPIF
RLYGAYIFCLCGFVLFQEGQLNLFVSSQYKPLLKHAYLLSIGLTVVSATWFMLSILLVDK
QWPKLVLLLKSAAGIVMILSILKIPTQQAQVSYLLSQIMAYITLVIVATIFVLSALQTKR
KIGEASLVFTALSLVLVGMVFRVLLVGYSPFMQRYALIFAFAIESLLLAVAVSKRIGRLR
QQKQQAENEANYDQLCAIFNRRGWYKQANVLVEQFNKRGGVLALFYIDLDKFKLINDQFG
HDAGDKALAHVATFLSSSIRKQDIVGRLGGDEFAALCLFDDTQSAEEKAQQLQQQLNTLQ
FSHGKQKVAIQGSVGRAFSQHPITDISDLIAQADKQMYQQKTLS
>A0A702LHM3|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A618PHQ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGNNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>F4VF89|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H591|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A633VXJ2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYLYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEWEKK
>A0A5T3C8M2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGHFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A378EDW8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWAASNTIPPAIPVS
TRWWPPPTA
>A0A378E967|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLVGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDS
>A0A633I806|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRSVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A744YUP3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQVGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379QRI5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGILVLSVLLLIW
HGKYRQKRINLPFISILFGGLWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLHSLPSVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFTLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQALGSYQHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVCRFGGEEFLVLLTAAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDVRAI
>A0A511B107|diguanylate cyclase|EC 2.7.7.65|Gluconobacter wancherniae NBRC 103581|TrEMBL
MTAAVPSEASLVLSADEAEWQRIIDAIEPSVREAVALVVKDHAADSVELFYTTLRQHPDA
APFLSNELVDTRLHAALITWLTSLFSVAAPDLIALVTTQKRIGLVHARIRVPIQAVMHGA
RLLKGELRHLLFDRIPSKEDLSKAIDYVENMMDMASETMSREFVRDLQKEIETDEAYRLV
TLGQDINLEREIQKAALLDWGHRVLFAICCAAPPPLPSLEGSAFGLWLNHKGSLLFPGPF
GLEPIKIAMRKIDHVTIPALLADAPPKPVQIYELQAQIEEIRFLMDNLFRTSEARESGRD
PLTCTLNRRFLPTILSREVTQAMRREVPFSVLMLDIDHFKSVNDTFGHTCGDRVLRGVAE
KIVSACRASDFIFRYGGEEFLIALVEIDMDEAFRIAERIREMVSDASTDSFGVKVTVSIG
VATFDGHPDYTHLIEDADKALYKAKDLGRNKSVAL
>A0A378EI92|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAICFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDAQMQPWQLFSTRLGIAAVLISPVIVASSVEVINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A743WXY8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A518IRP8|diguanylate cyclase|EC 2.7.7.65|Rosistilla oblonga|TrEMBL
MAMWTATVLLTLRMTGLLDDGASQQIQSRTRLCEVIAVNCSQFASRDDQAAIEVALRALT
ARNDDVLSAACRKADGSLAFASQGHQANWSPRDGEASSSTCIQVPVMQGDRVWGQVEVCF
QSPAATGLLGFLALPSVKLTVLTTLGCLVGFQLLLRRCFNQLDPNQAVPERVRSALDTMA
EGVVVLDEKYRINLANQQFADMIGCTVDECQGKNIDWFPWDTQDERPLSELLSELNGEDP
KIFENIKLRKSETCRRTLKPNASRILNKQGECKGMLLSLDDVSVLEEQNEQLRFLATRDP
MTSCLNRRSFFEYLEEAWILAERHKHPISCLMVDVDHFKGINDSFGHAVGDEVLKGVSAA
LLATARESDYVCRYGGEEFCVLLQHCDIDGAACAGERYRAAIESLQFPQLSVTASLGCSS
ADLGAESAEQMLEQADQSLYAAKRNGRNQVARFDRMESTIQEIEAAAEQDNSTAEESLLD
SVKDLISDARDAGATSVSVDQLNVAIKESSQRPSS
>A0A663BB10|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIQAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEIQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKSAFRESDILA
RQGGDEFIILFANTSRHDAAAAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A518INF4|diguanylate cyclase|EC 2.7.7.65|Rosistilla oblonga|TrEMBL
MIDTTPTSKPSQPAENPPLAGAVDGIERISSLLGDLNRLPSGTVASRQEYDADGAHENQL
LAVRLGVATSLFYSLRCKHRQTADHSLRVALGCSVWADRLQLPAELRDRLEVAALLHDIG
NIATPDRVLKKPGHLSNDERLIMDQAPDVACEILAGCCSDEGLLDILRYSRHWYSGGNGS
GQVQGDDLPLGARMLAIVESFDSMTTDQVYRRAFSQERAVAELFQCAGNQFDPDLVRDYA
ALLENRPELMYASAARRWLQDLQGDSSNRFWSAAPEKTGAAAGDRQTRQLLFHQHLLDTM
CDGVVAIDGEGVITHWNYAFERMTNIAADAMIGQVWSDSLIRWDDARASSGDVASLSKCL
TTGGQTRRRMRMGLPDGKEVPVKVNFIPILGEENRVQGALAIINDISQEESLEQKVQSLH
VKATRDGLTGVANRAEFDRALGDVVEFAAAGKGPASLILCDIDRFKSVNDNYGHQAGDDA
LISFSSVLVRHSRDGDLVARYGGEEFALLCPGCDNATAAKRAETIRSDLERITQPSLANK
CITASFGVTEYQSGDTESTIVARADRALYKAKENGRNRVVQLGSGLREPVESVSERSKGW
FQWLLTPSKSDQVTAKLVTRAPVEMVIEKLRGFIADHNAEILKVKDQQLELRLDVRTSLH
GRRNADGVSAFHLLVNLGERQVPTGPHGGESQLMETVIDASVSPWRSRDRRNREVKGACR
NVVASLKSYLMADYAQRP
>A0A663BAV3|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MVLFFSTLLIWREINVLEEAYVANQRNNLANVAHEMDGLLQFNIDRMMFFRHGMQSALER
PLDVDVLHEASQRYLNQRHQEIWRVALPNRRTLPVFGVSESVVREHPLLLPDDPLVVNEL
MATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVKTYYSRAISALWFTRQ
TQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPLAFAGYWRGVLAMDFSVSEIKAFLISAM
KGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPREQELLSRAFAHDNQGGLRLLTRYISWA
KLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWILFTLMLLLSWLVIRRMVRNMSVLQT
SLEWQAWHDALTRLLNRGALFEKAMAVASACQRSGLPLAVIQLDLDHFKSINDRYGHQAG
DECLSSVAQVLKMAVRAEDDLVARYGGEEFVVALPRVPLVHATAIAERIQQKIHEAALPH
EASEVASVVTVSIGIVDSDGTVPMETLIARADSALYQAKNKGRNQWSY
>A0A663B588|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVTPLFTVVRFTLPCALIVACSGLLLLW
HWKWPQSKINISAISLLFGMLWAWHVVTKAMLLTPPHFNYLVIALLSILFIGTIAFSNNI
TAFTLHSLPTFLACLIMAEGEQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMQ
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHFVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSEETAWQAAERIRQRVYDLKIPHM
FNESVATNVTISIGLTPLIDDNIEQALARADGALYEAKNKGRNIILAS
>H1WDI7|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MNQLMEDRSKILWIAGNVGNDNHSLPQSILQNNGYEVHLVIGLKPAYNAIQSWPLNLILL
DSKLHDGDSYELCNWLKSKAKFQKIPVIIMESRGDLLNKHTVFDVGAADYLTQPFHEQEM
LKRIGYQITLQRQKHQIKEQDLGLNFESHKSEIAKLALEKQRALLRMVIDANPNLIFIKD
WDGRFTLANRATANLYETTVDNMMGKTHSDLNHKQYNNDYILASDREIMTSGKPRLIAAE
PVRLNNGEVRWFQTNKIPLIGNDGQTPYLLVVSTDITERQEAEQELWSHAERERMLRAIV
QSLHECIDLEQVLECTVNQIREFLVSDRALIYRLENDGNYRVVMESVSPPWQPLLGTTIN
YSGLSEVITEMAAANYLKIWSISNVDKANIPINLRNKLDGLQVKSKLILPIIHRHPDLRS
QPTESPNCLWGLLVIHQCDNTRGWQPEEIEALRSIATPIAVAIQQGELHAKLQTVNQELE
RLASLDGLTGVANRRQFDLHLKREWQRLLRETAPISVIMCDVDFFKAYNDTYGHQMGDEC
LKQIAKILENCAQRSTDLASRYGGEEFVIVLPNTGIKGALQVADKIQHQIRALEIEHQKS
EVSGYVTLSLGVACQVPNHDRSPESLIKLADAALYEAKSKGRNCIIANAETI
>A0A290HNX6|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MMDQETLYELVIVVLAIFMTALYFYYKKKVCALKLHNIQLEQLSQYDDLTQIFNRRYFLE
IVNYHFKIIHQKNTSAVMMIDIDNFKQINDTYGHLLGDDVLKYTVKQINENLREDDIFAR
YGGDEFIVFFPFISRKDIHMIATRIQSKLEEHKIYDFSVTLSMGICLFSTFTPLLNVIEY
ADNALYLAKSKGRNRIEFY
>A0A8F9XB95|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MGDTSDLDPLNSELFDVNADLVHAIMELVSDGIWDWNANTGFVYRNPGWYEMLGYDHHSL
ENTVFTWESVIHPDDYPHVMKVFDDYINSRTPHYQAEYRCRKKDGTWLWIEDRGYIIARN
ADGSVSRMVGAHRSIHERKRSLEQLERRNQSLEALVAERTRELSRVNQQLQLQLEENRSL
AERDTLTRIANRYRLEKALLEECARAQRFRLPLAVIAMDVDDFKLINDQHGHAVGDATLL
RVVECLEHCVRQGDLLARWGGDEFMLIMPKSTVETARILAERIRRAVLDLPPMGDFNVTL
SLGVVQRLDGESPADLMARADQALYRSKAAGKDRVSQ
>A0A0M7MBF4|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MTTSLFFLVWGLATALALPLLLPLQARGVGGVRAFTIANGLAVLSLLAYASADIMPPGAY
VMVSNAAWLASVSLVYVGVRQFFGLRPLAVRAGLAAALCIVAMAAMLYRQDNLVGRLVVF
STFTCVLMIATGGVVYRQRQRIQTPGVVLYVLLAIAGLALLHALRVVVYGSGWVPVSSLL
DPAPWGLFFIVCGSVTVPALFLALLLLIQTVLSERMQAALTFDSLTGAYSRRSILDELEH
ELLRCERGDGRLAVLVLDIDHFKSINDRHGHATGDAALRHFAQAVPKAVRASDRFGRLGG
EEFVLLMYGCDAACALVQAQRVCDALRDSPLYLQGQALRMTVSGGVATFQPGDTADGILA
RADLALYKAKELGRDRVEMAWSGRMTGRQQAAREQGGEGAARDSATQEGGALAAEASNLT
A
>A0A1Y6KUY6|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MNISHSIRKKIIHYTLLCLGLLIVFNISYWSYNQYSNIHKLLSRNKAVTENNVATIISKH
TNLLTAISNDDIVKDTSLLLTQRIEIVRPYQEAFNIEILGISDIKGNAVTTYSDSIENIS
YRRYFQQAIQKNKLAISNLIYSPISNSYVYIICKAFTNADDSGTIFASVSYSEIKNALAY
QENTSIRNAILNNCRDSNNNCRNIKILKSDKLYSSLDSKQISKNITNKKTFNYYTINNNY
QLERLTLTPLKNTPWYLLTTLNYNQYLKDKFTFVIINILISILASVGLGFYLMKKVSIIT
SPIDDFIKESTGIIPIQSQSKNDNIVMNHHFNNIINTTKDGVYCSRTNLLNRKYFIQHAN
TTIQKYLNDFALLFIDLDNLKTINDTLGHHYGDDVIAMFAQHVTSFFNHPTDLIGRFGGD
EFIVLTNNYNKELDLITKLQKLVVDLNGSVSNGTLTIPFSASIGVALTDNETRDIEQLII
NADKAVYDSKKKGKNCYSFYIRH
>V6F6G5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MAGVCEGQGKGAGRSMTTILVVDDSKFFLSVLSSKLRSAGFSVIGAASIAEARVVLETRR
DEIFMALLDLFLPDGPEGEVVDLAISFGVPSVVFTGNYSEDTRDRVLSKRVIDYVVKDDP
SSLDYLTSLVHRLDHNRSIRAMVVDDATTARKYIADLLALYQFQVVEATNGEQALQRLAD
TDNIRLVITDYHMPVMDGFQLIKNIRKTWRRDQVAVIGVSSSGSSTLSAKFIKSGANDFL
NKPFLREEFFCRIAMNVDLMEQVDALKAAATTDYLTGIPNRRSFFERAQPLLAAAQRGQA
EVAVALIDLDHFKSINDSHGHETGDTALATVARLLVAECRQTDLVARFGGEEFCVLAFNL
AGESRDAYFERLRSRISDLNLDFNGQPITLSASIGVSSNVQLGLDGMIAEADQQLYRAKQ
EGRNRVCWLD
>V6EYT4|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MNLNIKISVLFAAIAAMLIALLMVISLFAFRSFSIASSSEHIRTAAEIVRVHLTESMING
VIDKRESFLKRLMEVQGLASARVVRSPAVVKQFGSGLHEEAPSDDLENQVLREGKAVYDI
IETENDTLIRGTIPFIATNRGEPNCLQCHDVQEGMVLGAVTMKVSIGNLKTQAMLTVAAL
ISIVALFMGIAFVLIRRMINPVSATAIDVENAVQRALRGDFKAKVDQITKDEIGQIATDM
NRLLAFLDQGLTRIGANVARLTSRTPSPDENQLSATIDMVEGLTRAAHFKQAIEEDETKA
EIHTRLVRALEGEFGIREFSIYEMQANKNHMTPLYVDGQPQASCRWCDPQILVRSEGCRA
RRTGHLVDGVLNPGICYSFMPPEEAMDRKHICLPIIQSGAVGNVLQLVVKPDEEAAMQEQ
LPYVSVYLREAAPVLETKKLMETLRESALRDPMTGLNNRRFLEEYVDTLVANVQRRQSQV
GIMMLDLDFFKMVNDTYGHDAGDAVIKAMAKVLRQAVRASDMVIRYGGEEFLIVLLDASP
EQADQIAEKIRSTVEALDIQAGTTVLRKTISIGVADFPSDSDTFWQAVKFADVALYQAKD
TGRNKVVRFNTDMWKDKSY
>A0A6F8ZDA7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MAGAMLVQAAGLGGLWGLALTGAWQLGSGLDGAAGARPWPVLLVAAMLAPAAAVPGAPVW
TLAWVLAGGGMALYDRRFHRLLTSLLTVAWLAGSGVAGWPPGVAAGALLFPLWAAAAPRL
GGPWSAAGAWAGGGLLLTLAGGPAVAAALPAQLAAAPLAAAPAVLWVCRRRRLDQALDDQ
RFRVEHDALTGALSRTGLERWLAAHNRVPGMVVAIDLDDFKWINDTYGHQAGDAVLREVV
ERLQPVLRAGDAVVRMGGDEFTVWLPGPGPADGADLAERLHTVLTVSPFVLPPLPPLMLG
ASMGWVAGPLSWNLAEAADAALLRAKRAGKNRVAGEGPGTAPAAAVPVSLRWLVDACEAL
WEHWDTAAVLADRQGRIVAANPAYQALTGYHLDELRGRSPAMLSAGNTDAGVYDALWGAL
TARRPWHGCLQNRRKDGSLWWEALSIYPVVMAGHTVGFWAVVREVPAPAASEAAAAVPVP
PGTGRAQPVDDDGGRV
>A0A379XU90|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica|TrEMBL
MAAGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPA
AALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVIVL
YPLLFAWVSYQTAITLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREAT
LLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPAD
SAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIAHYREWLKSADMALYKAKNAG
RNRTEVAA
>A0A5P9B458|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MRFSLFFILLIWSFWVSAQSKDVLVVHSYHQGFFWTDNFQKGLATELDRDDIPYRVVYLD
SKRAQSEEYFDKLYQLYRTKLANEEFSAVVVSDNNALNLMKRLALELNGTPVVFGGINNY
SPSMTEGLNATGITEDIDLNSNVTLIQRLQPMANKIYIVSDFSVTGEAVRAQVDRHLQQY
PQHASFIEHYQPRSYRELVNFAQQADMSKSLLFWVYYRDEKGNVSNDDDWRELNKLTKMP
IYMVHDLGLGFGAIGGVIQSGLSQGRETGLTLRRMLANPDQELPPVVEGAAEIKLDYQQL
NRWDLGEHSDLSATFYNKPQPFFERYQDEIRTLGLLFLAMGCVIVTLVYYLNRLKKSERD
SRKSQILLESIFDQSLQFMGIIDRDGVLLSSNSKLHELFYNQGYQVGTPIYQHQHWEDAA
SESLKKYFMEAQSYTSLRFEAEVWCRDRGVLVLDISLKPMPDSESSELQFLFEARDVTSR
KLAENKLFQREANLKLYYDKQPVMMITLDENNRIQQVNQFAEELLGYPLSELLGHRPREF
YVDRNAMIPRQILLQPQHKSRGVWRRDIQYRHADGSKIWIRENIRPLVDSNQLLIVGEDI
TETHELAEQLEYQARYDLLTHTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLN
DTAGHEAGDAAILFSAGLLENVLPYNAVLARMGGDEFAVLLKDCTERDAVNVCRSIIAMM
GDNAFLWDDIQLNLTCSIGIRLIDHTAASPQMVHAQADAACHAAKEEGRNRYNLYHQDDE
DLRRRHLEMECVNLVHEALAHDRIELFAQRILGLDKQSDLMHFEILVRIKNHNGEYISPG
IFMPASERYNIAHLIDRQVVSQTLAWLEENHGVIDELGMCSINLSGHSMGNREFVEFLID
SLEQSAVPCDKICLEITETAAMSNMNQAIELFTQLKELGCMIALDDFGSGLSSFGYLKKL
PVDIVKIDGLFVRDIDVNEMDHVMVRSINDLAKQMGKYTVAEFVENTQIIDKLIELGVNY
AQGYIIGRPKPLPELVEELRQERLV
>A0A174H7F9|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MVLGVVMLLLFIPLTRQKIVGIEFLNLGVTAFVSGLYLTTDGRYLQLVFGDAHIYHVIAE
TAMRLAIPPFLIFLSQMYDIYSKRISAILCVIGEIAFAGCFIGEITEIMDYHETLFLVHV
VFAISMLFILVSTIKGIVKAPKENIYHNIGCIVLSFMAMTDIIILWRGTGRETSYFIRLG
ILIFFFMEIVQIIKKFLASYQRNIKNELLSRLAYHDGLTDLLNRTSYMEKVKELEDDENP
YMLIAIYDVNNLKKVNDTMGHQKGDEMIKRVADVMSAYLGKYGQCYRVGGDEFVFISTKP
DIETVFMNASKKMMDNLGCITNGNNIVPITAAMGYAMQNDNSTKDINEIIHEADSRMYEK
KRSMKHRKA
>A0A1X7ALT9|diguanylate cyclase|EC 2.7.7.65|Parendozoicomonas haliclonae|TrEMBL
MTEISTKPTREIIPPLTSSDPREWKSTGVQDPRVFMALVSCYVIAIILEMVLLAIHSFAG
DKEIITLMVSCLGITTFCMTHFLITRKHTFSSITMALSLSCIAVYGLLVNHAFLGSTIWM
LFISPIVIFSMGLKWGLPVMIAILVVACLSIFNVTNSVAGVYNVLGRIREIFAFGGSIAL
SSAAYYIWEQTYDRMRLLTDQLENQAGCDPLTGLANRRLMYQQMERERSRALRTNQPYTI
LIADLDHFKLINDTYGHPGGDAALVMISNLFNRHLRRKDFIARWGGEEFLIMLGSTKSKD
AKDVAERIRTVLSKTPVKYGEHSFTVTVSVGIHTTDMQTTLEQEIALADECLYQAKMRGR
NQTVSSQTPPPQDAIPTAV
>A0A1V5DJT6|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaU1.Bin005|TrEMBL
MRNPLQKAPLRKRAEERLEGLQEAVSRTGVDIEWLVHELRVHQIEIEMQKEEMDEIRTRL
ETGLERFPESYDSVPIGLVSIKREGVIRAANRAAADLIGIERLRLINRPLGRFVSEPERP
ALKTFLERIFDGGADEACELRLAGNGGARTAVTVSATVSEDGKECLAILADITELKKKEE
ALREELQHHRALFENARVAISQVDEGGTFLRANKRFEALTGYTQEELKGMNIREIMHPDG
AGQVKEMIAGQVSGEIAPIFLEEYYVCKDGSRKWGEIRSRAIRDGGGGFLSAVVAIVDRT
RGKQMEEALADNESLGRSFFENASIAMFHSTLEPNRLLRVNSAYSRLLGYESPEDLMSAS
AGMDPFPEEAWDRKAFFAAMEQRNWYDGDYPLIRRDGGILIGKAAIRSVFKPDGSIDHLE
GIVENITERKRAEEVLQKRDRELQEKTKSLEEVDAALKVLLKNLEKNQEELTERFLINIR
EQVLPCLVKLKKTPLNQAQRALINSAEAYLDEIASPFVQKLTSSYLNLTKKEVQIAVLVR
DGKTSKEIAEIVNVSKSDVDFHRGKLREKLGLKNQKGSLTVLLRTLSHEGPRERP
>A0A654AJZ6|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MLPKTLKGRLTAAVTALVAAACVMVTAVALEVAYREMKESTGQQQYSLLTSAAAHLAFEL
ETKHTLLRTLAEEIALQQADGGAPIQDVLAHHPGLRQAFADLVVLDTAGRIAGLQQPGYF
LRSQLADSSCLQETLRAGAALTLQPPAGKANGRAVVVLSQPVVDAKGRTAFVLCGGTSLE
DSSFFGQAARLRPGATGYLFALTRDGTLLYHPDRGRHALKAGEAAPLPAMARAAMEGWDG
WAFGNDAQGTPSLLTYKQVGNSGWVLASAFPADEALAGIARARHHAWIWTAALAICAGVG
GWAIMVVLLRPLRALRRHVHAVEREEAEIGVLDLEREDEVGALGRAFHSLSVKRQIAEQQ
LKELSLTDTLTGLGNRRQFDHEVALLIDQASRYRFGLAVAFLDVDCFKAINDTYGHAAGD
AVLREFARRLRTVTRPTDRTYRLAGDEFVIVSERLESGENARRFAAKILRAIRRPFDIGA
GVSLPVTTSIGLAVARFPVAPVGDMMQHADAALYQTKRNGRDGYTIKELGMPAVASTPSR
RPGLRTVAP
>A0A653IRG1|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MINDGKQGRKANVAVSPWVTAGALYFLLAAATIHFSSNGRDIATVWPANAVLTAMLLHLP
RSRWLQILAAGFVANCAANLVTRGTIAGPLLYGVSNLLEVLIVALAAGRHGRSASILSAP
STLIRFILVAGLLAPLSSGIFGATTAYLIFDQKLATAFATWVLSDALGLLIFTPVFLAVF
RGDFRQWCRSAPGLLKMEALAHLVATSAIAGLVFFGAQKPLLFLIYAPVMFVTFRIGPLG
TKVAVMLVALIGAVATMRGYGPIVMFGTNPVGHAHMFQLFIAVLLLTCLPVAAEVSARAR
MTAQLAERERELSRRAVTDPLTGVFNRFGLEALTAPASAKQSQMCLVAIDVDHFKQINDR
WGHAGGDRALAHLASVLRTVVRPHDIVCRVGGDEFVLLLPGLDLTRGEAVCARILNELRT
RSFSPDGVNQITIALSCGVAVAQSGENYGDTLRRADEALYRAKSAGRNAVRAAA
>A0A2M9MLH6|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM1FR|TrEMBL
MESHINSYITLVATSAVLNVFLCLYTYFRRSEIPSSKIFILYTAALSIYTFGYAIELASN
TLEQMMFWTTVEYIGMPFSASLGLMLMIKYTGKTLSKKVTASLFVIPSITLGMVATNDFH
HLFYKKVWLREDSPVPLMDIAVGQWYVVHGAFTFSCLLCACLILIGQWRHTKKMYRRQLL
TLITSQIIPMVAAFLYLLGLTPGGMDPVPVLMCITSAMYIWAILSSRLLTIVPIAKDSIF
ESMREGVIVLDSFNRLVDYNRSLRDMLPELNTTMIGQPLDEIWLNLAGKTFPVEYGREGL
QTDLYWQLNGETVCYQVRTSYVYNKDAQTVGSLIMLIDITEQRFLQEQLKQLAYFDGLTK
IYNRTQFLHRGREILSEAQLNPQPVSFILFDIDYFKRINDTYGHDVGDQAIIHVVSVCNR
YLSPEMLFARYGGEEFVIALPNTSLQEAEKLAEQLRVALLNDPLDVKGVPITLTSSFGIA
QYNGGADSLESLLRDADTALYESKRNGRNAVRAYTVSTT
>A0A518GFQ9|diguanylate cyclase|EC 2.7.7.65|Aureliella helgolandensis|TrEMBL
MAAQPNVSPSNQAQGATTPEVSPTSDAAASARGSVSGVGNTVLQTAEQIEHKLQMESRRQ
VLAAQQSSGLDQLVRARLGIYSGLFFALRAKHPPTAAHGLRVAMGCSKWAGWRGMSEDER
GLLEVAALLHDVGKIGVPDSVLQKPTQLDGREQMMMEMNYGTAAEMLRGAGGGERLISLV
RDARGEYANAHGEVSDYSLGARMLSIVDAFDSMTAEQVFRRPLSRERAVDELFGHAGTQF
DPELVKEFSKLIDEVRPDLEAAVANRWLNELAPDPTPGFWESEVPVSCGAMQTLVDTLFH
RRMLDSLIDAAVYLDADGQVLIWNRAAERITGRQASSLIQHQWSRELMGLHEADGKELGN
EDCPLVQMLSANVVVTKRLQIKHTDGRAVQVQFTALPVFAAGKQYAGAILVARDTSTQAN
LEQRVESLETIATSDALTGVSNRAALDTELPKFVEEHLGTGQSGSLMICDIDHFKKINDT
FGHQAGDEALVTFAGVLREGAREGDMVARFGGEEFILLCAACNISTATHRAEEIRRAVGR
TPIASLKNTSVTASFGVTEIQPGDCPSTLLARADRALLSAKESGRNRVVQLGAGQGNEAG
TAATESPAEKPKKRPWWHIFRPQRLPPLLETSLLASVPYEIAVQKLSGFVHDHQAEIIKS
DGTLLCLKIDGQNLADKRRSTERTSTLLLNLTVVAVQFRTSRNNTYQSRTRLDVIILPYR
PRDRRAPNLESQATRLLASFNSYLVAQVIDDSVRENIFESR
>A0A653IWA9|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MPRTAAAILGRRSARKAACQAGDLPGAGSMRTAYRAKEVSKVWDVGRGRLDRSGTNAMPF
SVTEPVSDRVYVAQVLSLFSSVATSTVTAGIFIIVLFIAYQKVGNPVFVAVGIAGCVLNV
WRISACLWLRKLASGRVITRDEARRFEAQFAAPHLGFAAALGAFSFLIFRGAQTELHMLT
ICVAFGYCAGVVANCGSRPVLALGSILLAIGPIICISATKQEPVYSALAVVATALICGAG
RSMIVRYDEARKEIAARISSVSMARRDGLTSLPNRLALDEFFNARLALSVTGTVVAVHYV
DLDGFKPVNDKYGHAAGDQLLIAVADRLRKAIRMSDMVARLGGDEFAIVQFGLKNEDEAF
ELSWRVRDAMEQPFAIDQSSILITASLGTIVSADRAANLHHLLQLADTQLYGIKRARHRL
RLTATL
>E1V3A6|diguanylate cyclase|EC 2.7.7.65|Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)|TrEMBL
MLSLILLGSIAAPAQASATALTDGWEYRWGDSPIADDGTPIWIRGESNDTDWQAIDFPSN
PPERNGSHHAWFRITLPMTREWRDPVVYIYSVDLIVEAYLEGRRIYHYGNFDAHGEGRFA
GWPWHMIELPRDFAGKTLYFRVYSDYTDIGLWGEVKLMEHAELLGYLLRHSTVDLVISII
CLLLALLAGVFTLIQAGTRHYFAPIALFAFASGIMILANTQASQLLVSRPLMWSYLAAGS
YYTLPIAIGLLLEHWYTDTRTRLIHRIWQFHLLYLVAALGAALAGWVNLSTTFPVFDLLL
VTSLCLLMAAIVPRLPELDGKQQAILGSFAFFSLLLVTDMAVAHGLLPWFRVPVSSGALI
FVLALVTISLLEYNRTHQELKRLNLRLEQEVAQRTGELQTLVKRLESFSYTDPLTGLHNR
RYFTKLLEQSTAQAQRQGYPLTLLMIDIDHFKQINDRYGHEAGDSVLAAIAHCLSQYFRE
ADVVCRLGGEEFAVLMHNTETSAVKERAEALLKTLACTVQHHQQIPLGPVTISCGIASYP
LHAVNPQALVGLADKALYNAKHAGRARIHVYA
>A0A4P7P0J8|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MNHQVIARKAIEHLTKHNIKPSPVTFSIWFLYYLGQNKALISRVKSLLSTGQEISDASYE
KLYEVYVLKEHFRDSLGINRNTSQIINKANDLKAKIHEFVESIRGHKDTLGDMRESLTVA
ETREAIEIILSEAIMELKTVETDSVETTLWMQKNVKELESVQNEVIEIEQSMSRDFLTGL
PDKTYFEKTLMEFLKESMSGVISKRHFIVFDITDLDYYNEAFSWLLGDSIIRLVVKIIQT
ETDENWEMMRLSEDELAVFPPPSFPIHKIPDYIERIRTIIHSKKVVVKNKQQEIKNISLS
AVIVKVAVYDDVETVNDKIQKGLDIIKEGQNGKVIKIDE
>E1V827|diguanylate cyclase|EC 2.7.7.65|Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)|TrEMBL
MPTRFSRYLHGALSLTGRLLLGLFVTWGVVVALLLGLGWRSGETLVGESSRTHLRYEVRL
IADELAQQVDSRLSALERLAARLDEADSEGGGRDTLRRSDALLEWFDGLVVIDAEGRVVS
DWPKLDRRVGLNIGDREYFQHVRAFKRPHVSEPFHGRASDVPLVMFMVPRLDESGAFRGL
VGGIVKVHGGGLFNRLNRIRLGAQGGAVVVTSSGQVLYHSDDSLVLDTVPDPQDNPWVNL
ALYGWEGEALGTMFGGDMAYQAYRQIWPANWIVGVILPRSQVMAPLREWVSRLGWWALLV
ASLLIPVMGWLVWLALRPLYRLETQIDEVGRGLRSRVALTTRMQELQRVARTFNRVEVER
EHAISRLQERQAFLDATLSSSPVGIFVTDRDGEVTYVNPALVELSGHDAEDHLPLTWRER
IHVDDRQSVLDLWQYSLDSGDDFLQQYRFHRRDGEMLWFEVHARRVVSGDTHLGFVGTVK
DITERREEEALRQWEAEHDPLTGLLNRRGLERRLEEALADWRKTGTPSVLLIFDLDRFKP
INDLGGHALGDEMLCQVARALSRTVRRSDHTARQGGDEFAVLLPSCTFERAQDIAESLRE
TIRELQVVHGGRVFSVTLSLGVTCFERGDQRIESVMQRADAASYRAKRMGRDRVVMHGEA
>A0A5C5Y1T1|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MKLFRTYFAALRIAFALTCVSVGLLISAQMFGVVPDVDHERTKAKQSYCESVAIHAAMAV
RRGQWSDLDGTLKTLVDRNPELLSVGVRSDLGILRLDTGYHESFWAADSGRNDSTPQDST
TDDSSLPIQTAGSMSSMMSPAASTPDQPVDSGLLSTAKNRIRQTATEMWDDLIGLPGKLA
SLPEEIRQSLRDTGDESAAVKTNTVEVPITLNRRPWGTVEFSFQGDQASLWGSLTSRSLF
PLTLYVGFAGLFAYFTVMAKIMGAFTGSQVVPDRVRGALDTLAEGLLLLDDKGHIVLANQ
AFLSCTGSVASEVRDRKIDELPWVHDADSNEDQHPWLRSIQSSESITTSIQRYRISSGEV
RVFSVNTAPIGGDNSKRGALVTLRDVTHIEAHRAEQERMLSMLRSSRDEIRRKNRELELL
ATRDSLTNCLNRRAFFERFETLYSTATSNGTTLACLMFDNDHFKSVNDNYGHHIGDEVLR
KVSKTIRDRHESRHLVCRYGGEEFCVVMPGCDLQHAIHEAEETRRAIMEIRLDDPAELRL
TASIGVSELVNDPADPQELINQADACLYIAKQRGRNRVVAYEPGFEEQQESAKADDSRAA
PSTAASVNGPAVPFQAVTALLGALSYRDSQTAEHSCRVADLCVRTARGLVDQKQLYMFEV
AGLLHDIGKIGVPDHVLLKPGKLTAAEWKLMGEHDRIGVDIIEGTFDSPMLTEIIHSHHA
FYAGGGRHDDLPHGKDIPLGARILTIADSYDAMVSDRVYRKGRSHEEAVEELRRCAGTQF
DPDLVERFIEKIHPSELGQGLDENGLTKQAALKIGMHVELIADAMDHRDVNRLRELAVTL
SGLAKSHQIDAIAHCAHSIETRAVESLERVKTAETATGISAFEIMDPEQEEENDWMQLLC
EANNLLDLCRATQNVYLGDTTERNRQIIENFLADVDA
>A0A1U9YYQ8|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MQALPLLDFKTLEVVNLVVAIIAAVVWATTGLAYRGLPAARYLFGSSLAVSFGAALKTGL
SPDSAAWISILALESIVCGLWLLYCGVRSFFGRPIRARQAATALLVTLALLIVFHQRWLL
REAIFVFAQILPLFLLLPLFVKHGSRNSFGIQLAAAGAVIGIFSYLTIGLACAAKGLELY
AIPSLEHVQTYGLLLGMVSASLLVFGIALMIIEHLLHEAENMAKRDELTGISNRRDFMFQ
IERVHALCAAANMPYSVLLIDIDKFKNWNDSYGHAVGDEALRHFTRTALDQLHSDTRLLA
RTGGDEFSLLLPGEGAEQAAEIAKTLVEQVRARAVCVNGKVLHLTVSVGVAVYMPGSQAG
YNDILAHADVALYGSKNAGRDRYTVFDKRNVRDDDAPFPARFRLVDKPGAPPAGVGERRK
QGLPQSG
>A0A5C6FTR0|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MNNIGLDILVAVTCGCGGAVVGWLMHALHRSIMPSPPSEHESHPSHNDPSGQSKGRSSHS
ASTNEQTTRRLAEIAERLRGFATTMAADVDAHQSRVQAVNHSLLGRQDSATPQDIIDSVN
ELIEANEQMQHQLNSAQRRIQEQSAQLETAEKRAQTDPLTMLANRRVFDETLAQHHLNGA
KCSAALGLIDLDHFKRVNDIYGHRAGDEVLRHTAAILNARLKPFGTVARFGGEEFAIVID
NQDRDESLVILEQARTAIGEREIIFEDQCLRVTSCLGVAFLEPGETTQQWLQRADEALYH
SKENGRNCGHWMQQKTPRPMNHPTGFGPKPNASDASDSNGAPSTTSVSSASAIVGAEAIT
GGNPTSTSVNASPANAQATSKAESATITPPKPTTGVVASLPAIDDLETKLSQQRRGGAMT
AGTQVLAIRLSGKASPLKMRSLLQVVRASSRNVDEIGGYDDHTILLVMPSADQATALARG
KQVCSAAQSLRLGTTDAQHRHPVAIGVVESSPDQTLVDLANLAAKLANETAAHGDAPVAI
AGGLAAV
>A0A4U8QA33|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MLKSQNQNDIDYIHNVYRNIAFLGIILHTVYAFIYIYFQIVPAFAYNILSVLFYTILVMI
VSKHKYALTVVLIHLEACIFVITQTLLFGWDAGFYMFLIAMASMVYFCPFRSSYTPYIFS
FMHIATMFILYFYFIRHNPMVYSEKTSLYLYFSCNSISMFIMILYTAYVSKISALVNKKE
LINENRNLRELADYDQLTGLYSRRYLKDCFNICPGDNSYLAIGDIDNFKRVNDTYGHICG
DFILKEMAEQMRSQFDPNVFLCRWGGEEFVLVFSEAEYSDPKKQLESFCRWISNYQFQYN
DSSIPVTITFGVTKGTNNLPLNDWIDQADNLLYQGKRSGKNRVIADIKRRTNERTNERIH
E
>A0A377P249|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNHIFASNANMPKARPTLRSMFQRIHLMIIAITLLMAGIPLSVLSVFTLKTYAEHNLQLV
ASTISYTSAAAVVFGDKPAAQEALTLIARKEQIYEARIYDQKKELLASWTSPTRLHMTID
DPIRKWLLPKMVVQPIMSENEVVGYVTLTAGGATMVKFLGNLMLGLLSCLVLTALLSFWL
VRRMHTGIVDELQNIAHVARSARENRAFSLRVRPSQIAEINELSRGFNSLLREMELQQAD
LVNENDQLSYKALHDPLTSLPNRSNFMSMLESMNTAQEQICVMFLDGDGFKAVNDTWGHA
AGDHVLTTIAERLRTQIRKSDLVARMGGDEFSILLRHIAHKDDVMQIIDKIVKAMRETIY
LPNGEPVFISLSIGFTLSHAQSTPVELLEKADAAMYHSKHSGGGWSIS
>A0A5I9SE39|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Meleagridis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379WRK0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MGAFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRYRG
SPQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSMPLGSLAAPFGRTTSPDG
>A0A379VTU2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDVNQDNLKNI
FYTQDRPLVWRYLNVTLKDLDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVSLSLDLTYF
LVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTPVLEQRLQR
LVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAIRLGGDEFC
IILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQASDAQLYLN
KQQKQHRSS
>A0A509DVG8|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MQVISISVGRVTTHLFLFVQSIFKQMQTSAIVFFRHVEVYRATSVLRNTKGIDGASTGKE
TEQALVCTSLDSFQELNSSKISDKQYMASTATSPSASEGGSENNQAGKVLNSGNNSGRSN
SSEDVINVLIVEDDIDDFYLVRQILGRDSARKYDIVHCDSLQQSLDMLQRTKVDIILLDL
GLGDSSGLETLQHMANAIMFSTPIVVLTGTNDVELGERAIKVGAEDYVPKEEANTSLLSR
SIRYSIERHFLLQQFQQRATTDPLTLLPNRSALMERIENLMLDVSRNHAKMAIAMMDLDG
FKEINDSFGHQAGDEVLKEIAERMKMRLRCSDMAARLGGDEFVLLLTNYHNHNELLDVLQ
RKQKRLSQSMNLTVQDATHEVSVGISIGVAEWKQGLSAHQLLAIADEAMYDSKRKGKNMI
TLSEE
>A0A3T9SJT0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNEENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A377P5S0|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MKKTEVSGGAIKVNKFVIFSIVLLIVLFVLFRMFGYIRLPALEALFPVSTSVTLVLNVLL
ALFMLMKFSVDRKHLYLVVLAFAYGISSLYLMSKLLSYPGVIFTEGGIGTNANDLAIYFI
FRSASMAIFFLLSLVVYRLWNNRFINMISVMVLCTCLTIILLSTAYFVSSHSLVLSLPIV
DEGSLSYQQFWSSSVGLYLVLLWGGTTCAVMWFAGVKNNFWASLSLSCIAFLGSTMLLSG
SEYLTSLAWYGAHLFEVLATFVVMLAFLFDIFKLYQKARIDYKISYNNSIRDPMTRLYNR
SYYYDSLVNRIKSASKNAPITLLVADIDHFKRINDIYGHITGDRVIQYVAKTLQDSIRKT
DIAARIGGEEFSVMLDGVNRDDALEIAEKIRVKICHHQDSPYGQDVPEKITISIGIYTVM
DNELTAEQCVAHADEAMYQAKQEGRDRVVIYSACTTQIMRRENSAPLRVIYT
>A0A625R573|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYQEWLKSADMALYKAKN
AGRNRTEVAA
>A0A379WQB8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIA
>A0A822WI89|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MFYYAGSLKIQHNMQMQTSSAWESFYVMSDLILARVSETLATEQSLESLVRQLLEMLEIV
TDMESTYLTKVDITARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTLFSNDVPE
RWPECEAAKALGITTYMSIPVHLADGSLYGTLCATSTAKKPLSARGEQMLKLFAGLISQY
IQKESLVTQLREANAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNAIIAFIDL
DDFKLINDRYGHEAGDQFLIEVGKRLTAEKQQDDIIGRLGGDEFLVATLSNVEDEEQIHL
LRTRLSARIAGEYWLGSISIIYPGASLGVIEVDPGVTDPDSALRAADIAMYQDKKGKSKT
GFLAMD
>A0A509E4M3|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MSGGERKRNKIGFARRIHASRTIGLILAGIAFIPAFYELQQPLWVWLAFGGYFLVWPHLA
YLWSSIYNDSLRMGQNHLLIDAFCCGIGVAAMKFHLVPSAILMTMVALNNISSGGLPLFS
RGLIMQVLGIFAGTWVFGWHPQWQNSVAVTIACLPMLAIYPLAIGLYSYRFATRIHEQKL
QLRKLSRTDGLTGLYNRTYWQLRAVEEFERCERNRKHAVLIMLDIDHFKNINDTYGHDVG
DDVIRRVSEVLNRQLRNIDIIGRFGGEEFCIVLPDITVNDSKKIAERLRILIASESIGQG
NINVQCTVSLGIAEFTQHLQGVDEWIKAADTALYEAKNNGRNCYCIAPATKGLHLIGERS
GEAAAQRKNLSIE
>A0A8F8D5J8|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSVAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEIRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTTLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDTLRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A482IQL4|diguanylate cyclase|EC 2.7.7.65|Cupriavidus metallidurans|TrEMBL
MHSAPDTGQLVPSDRFLSRLWLALIKRPRRFILIAFSAAILLILLLILRGMMLSRDTEIE
SVRQMQAVRAVSINALLQLEAERLTNIRNYAEHLMQIQDELPALFAHDIQTAFEHRNDDV
WALRTRDAAPVYGVSAARLTGLDGFSRDDAKLIPSMAVAIALSHMFSAGHNEPGLRERIA
YVSGSGIIVAYPAISEQDVNPTLRSLASAGYFRNNLPLANPTRKQQWSIARSMDDIGESS
LFLSAPVYAGNEFKAVLILEIPRHSLDESLNVAPHHDVNNYLLDQNGALVGASMRNVHRG
ETLASVLIDKWPADKLAVAFRSDAGILSNEHGSRLIYRKLGNSGLIMVDEVSTRELLQAS
VARLSGAIGAGAVALGLLLCFTLAIVHTLFGHYIARGEALRTLAETDALTGLANRRVFAS
RFADAYAWCKRDAVPVSLIMLDIDRFKKINDRWGHASGDVVLRTLADALRANVRKIDLPA
RLGGEEFAVLLPRTGIADAANLAEKLRLALQALVCEPVDSDDTASIRFTASFGVAQIAPG
EPGSLDSLLMVADQRLYAAKAGGRNKVVWDEPQPEEMANEKPAKGT
>A0A0U5INY6|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MNDDQGQYDSLGIGMSAPLYDPDRNFLGVVTADVALSQLGDFLRTPLADLDGTAFIAEAD
GNLLATSGEDPIYRLDGPDTLRIRADQSDHPGVRAAGLAIRDSGAASGDGLIEVEKQRYL
LDWQSVQWPDGPSLTLALALPESRFAGPAHQALRDIAYLAPAFLVAGLLVALFFAYWFVQ
PLLTLERWARQLGRGQFQATPPIARPIREIAGLTLSLGAMAEHLRRHAEELEQRVAERTE
TLAVANRQLAELAVTDGLTGIANRRRFDETLAAEWSRAVRRGQPLALLLVDVDWFKRYND
HRGHPAGDEALKQVAAVLQRNARRPGDLAARYGGEEFTVIAADTPPAAALRMAESIRAGI
EALGLPHPGAAGGRVTISIVVA
>A0A0U5IHJ5|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MVSADPDRIDLREQATLSALIEQAYRQLPIALVVSLVNALLLTGVLWGAIEKATLLIWLV
CLVSVTAFRFRAQHAFLDPLRRARVDDAVWRRDFVTGACAAGLVWGGAGIFLFHPSSFTH
QVFLAFVLGGMVAGGVPLLSPLKHAYPCFAIPIVLSTTFSMLLVGDGVHLIMGLMILVFG
IAMLSSSARVRRLFQDATDMRLKLASSIAEGSALQEMLRIDELTRIGNRRFFEEQLANEW
KRADRAGNTLAVISADVDHFKAYNDRYGHPAGDRCLIGVARAMASALQRPGDAAARIGGE
EFAFVLPQTSFLGAEQVAERIRETVWDLNLPHAASPVAERVTVSLGVASSDHASVASAAD
LIRASDAALYEAKRRGRNRVATIAP
>A0A4Y8G1B0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRGLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B5M7H5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A811VV47|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGSIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A8F8Y4H9|diguanylate cyclase|EC 2.7.7.65|Nonomuraea coxensis DSM 45129|TrEMBL
MAATSHASIQPRDGVSTLVGRWPLLGQRRALVIYLAAMVTLDLAAITVFTLTLDFRWPDV
YTFAALMGCGVVCIEATRRLGVPAGVSRDLLSAWWLPVALLLPPLYALLAPIVLQALLQV
RVRATVLYRRVTNSAAIGLAGCTASVLFHRFVADPGLLSQGSGPPIVFAVVAAILFALLN
IALIAIAALTADPEMNRRELLWDKESLLLDIVELCLGISVAILCGLNLALLLLALPPVVL
LQRSLLHAQLQAAARTDAKTGLLNAAAWQREADMEIVRARRTNDALALLIIDIDHFKRVN
DAHGHLAGDQVLIGVASTLRSQLREYDVVGRFGGEEFVVLLPGADTHEARRVAERLRARI
RHLAVPVEDSLIRVTISIGVALLSVHGDDLIELLAAADLALYRAKELGRDRVCVSAIQPQ
SEPPPATHPQPDPHPLPDPHHSHLQPHPHPEIPPQSPPLTQPQSQTQPQHTPTSAPEHEP
QPSAPAQPQAQPSASAQPQKRPQREAQPQSQSRPQPSVQPEPSASVSAQPQAQPSASAHP
QDPLQPQDPPQVQDPAQPQAQPPATPQPQAQVRPLPEPEA
>A0A7L7E7A5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGALVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQTAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRLFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEVILEHAESVQKLRLAGCRIVLNQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A369FL35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEIGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H1SWJ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNSGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H1WPQ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
HLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMTVAFYRHAGRMWPGIALSCSLGNI
AASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQNLADWLRLAFGSAIVPPL
LGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPHYLLRHRNPRLLFESLLT
LAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLL
ATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISESETRFRNAMEYSAIGMAL
VGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSME
KRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEA
GGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQS
RSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERL
HITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMEN
IYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQ
LSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGD
ALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEG
RVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAAM
SLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQKFRRSFSDPA
LSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLVNDLLEQLENSPLPPRLL
HLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQ
GNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLV
NSSYFAIN
>A0A5I0MHQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durban|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5D8T2B4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TXYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A828FN27|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMQYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAVDPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISTINDYHFMWEGRVHRVGASAGITLFDNSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSLDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A2X7FNJ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRMLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A826SLB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSNDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRMEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B5L6W6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLFQIADEALYIAKRRGRNRVELWKASL
>A0A8H0XKC9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGTWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIE
>A0A0A8WLV4|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. MBES04|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A8H0NM70|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIAPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A346GIT3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVFSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2X1KUN8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKITRACRSQYVSGQTPACRKAGEITRIYRYDKAPG
STPGFHLTNTDWLPVPSGKVYS
>A0A376S7I8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDY
SAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKDGK
>A0A376JHW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFLEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTRQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A6N4PAW0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377FEN2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQT
ATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSI
NDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEG
LNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>A0A376Y979|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKFMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A378AAT2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MGRSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGL
ISKWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISISGADRQHSARLVHRPCC
>A0A6C9QIG8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PADSAIT
>A0A376KWK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFCFWGADSCSHTF
>A0A6D1C2I8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEVCRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A377BBQ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAM
>A0A376M7Q3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRVMVPTY
>A0A485JDL4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
DNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGRPCSFSCCRIN
>A0A377KAY3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGVNALPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWW
LSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNC
RRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQFTNYPTR
>A0A6N9MM05|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALALAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5I2Z4Z1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durban|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A377DUV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVPK
>A0A377DQB1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGH
AAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIIQCRE
>A0A5P0JIR3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVLEDAYISSQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEF
EQHRDEHAWQIELNRRRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAH
NTSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFT
SQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSK
LRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVH
TLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTR
LYNRGALFEKARPLAKLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISS
SLRAQDVAGRVGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGV
>A0A7W8JZE2|diguanylate cyclase|EC 2.7.7.65|Deinococcus humi|TrEMBL
MTGVFLLSLTSTLRANRNALFRLLVRYLGAVSVAFLLLLNTVQVAPGLLLDLRAVIVALA
AQRHGFLAGLLVAIPVALYRLLLAGAGAGPSVLGLLLITALFSWRTGLFRTKPNVELLPW
WRPLVLFGLTSLTTFLGFTLAGKSLLEALPVYLAMTCLSVLGLLTAQAVDQTRLRALART
EHLEQLVYLDPLTGAFNRRRFDDDLGHPEPPAFLLLLDLDHFKRVNDTYGHEAGDQVLAA
TVQVLQETVRLTDSVYRLGGEEFAVLLSPCAPDAAFRMSERVRHAVARDVAPRAGLSGEQ
VTVSGGLIPVAGLKRDILRAADDLLYSAKRAGRNCILVPQP
>A0A6N8QKV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKADAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHW
>A0A5D8SQ91|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNXEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1C3RKC7|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MYRQTDRRNEATLFNHMQSLRNLSRSPSVLCGDLYGAMGDIIHTLSATLENARIGIWVCD
RDDPDLWQCLASTQSNTETFKRKELEDLIKRLDQDFIYAIDNASTLPRNEAKPVHFFTPH
ICAQLCASIQIDAQTLGIICCEYDDGPHRWALEEIYFTESIANFTSLFLIDYNRRVAEMK
LFEAMRNDQLTGLANSSYFIQELKKKIALRPDCPLFLSLLDIRGFRHINDIHGHDVGDET
LKNLALHLTRCFPDALIGRTASNEFILARYIENNEDMAKTSDQIIKLLKIDLPVGNDRLL
LDVSIGAALYPQHGTRVKSLIRKCDIALFKAKETANASFVTFNEHLGQDYINHIRLKKKL
KTALFDHRLINHYQPKVNLQNLEATTGEVLVRWQDQQGQFIPPAHFIPIAERTGMINELG
RQVHNNICNDLCLVDAFSQSGHILSVNASVMELRNPNYVAQLLERMSQCHVKPHQLEIEV
TESTFLDEDRITLENLKQLKKEGFALALDDFGTGYSSLSYLKQVHFDTIKIDRSFVTNIH
QSKQNRDIATSLIKLFHDFDCQVVAEGIEFEAEADILRDLGCDFGQGFLYAAPMGIDEYA
QYLDCSPISPKLSLGLFNSTQET
>A0A377B9Z1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPTVGVTVLRHAILASPHF
>A0A5N8HEB8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYG
>F5RJX2|diguanylate cyclase|EC 2.7.7.65|Centipeda periodontii DSM 2778|TrEMBL
MNKVLVFLRGNFLTLLCIGLLVGATALAWRLLATPLDPHMHAEYAVMKGNPEYKDIIGFR
AGNFDWQEYDYPAPPPMPDGTTTVYLSWRIPLSARFVNDHILFSTTNQNVYVYLDNELVY
MHGDWSNPMASRGRAFHYVHLDQNLAGKRLTIMLHSGYPNWIGSLDYFMLGSSRLFLRNL
SLADAIYISSLSVAIVLIVFLIMDLAWRGAKAGRRRMQLYLIAFLASFILWTTGTSSFFP
RIYGMADLWWEIHLVMLYIMPLTCARITQEIVAPHYTARVRMIMVVFALLFGIATVAELL
GLDGFMNLLFLFYPLLLIGCLLLVYTLVRSSWTYHPACRYGSFAIIVIVIFGGIDALHWE
YHQLSVMLSTTVFSIYAAIPFIFYTIREQMLADASLARQNEELARELEISQNEAQRDFLT
GAYNRHQLGNGFATFSALSYKRGFKFSFAIFDVDHFKTVNDTKGHLAGDQILRQIADTIH
ARIDRRHLFIRYGGDEFVLLALHYDLAAMVAFCDHLRSILEQSLDGVTLSFGVSTWHGKK
DRLRALIDRADRALYISKEKGRNVVSAENEEGAA
>A0A5W8CGK6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Colindale|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1S7LK61|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MMAAPSPTDIDLLKSLTILYVEDNLEIQEQLALFLRRRLDHLILAGDGEEGLALFRQRKP
DLVITDILMPKMDGLSMARTIREEDDSIPIIVTTAYNDEKFFLRAIELSIDHFVLKPTDP
HQLIQVLLRSGRQLWREREREAANRYVRFLLDIQPNLLMVVDDGHIEFLNQAFLNFLELE
ELHHFREQMEQGLDIVLTLDENNYSLSKESSWVAGMLLERQQAIIYLRCTGCACKGAQNP
QNNMTLQPFAATVNTLEGENKLIFTFADITRIETQMRRLEHIAFTDGLTGICNRARLQQV
LDAEIKRTERLGAGFSVILFDIDFFKQVNDTFGHQAGDDVLRTLATTISENLRAVDTLAR
WGGEEFMVVSPEINLEAAYHVAEKLRILIEQTDFPIDKQVTSSFGVTSYHECDSVRRLTE
RVDFALYQAKQNGRNQVIQVVEKAHCEGARPAILKIDDVEFLPTPEK
>A0A3P5X960|diguanylate cyclase|EC 2.7.7.65|Filibacter tadaridae|TrEMBL
MTNHQLTLLQIKSDLMDLWTSLNAVRTYEEWFEVLKKTLTNHFDIEYADFFVYDKEKFMP
IKGYRSALKGQNAVRFDSEQERNEDFNAAYLERFKEKGFAYADDFVIFEGGDTEPLGLLL
IQSTDKWSVFSNSPSLNELKKVVSRLILTVRKMVSLVKSEKNYKELFSVTELFNSTMDSQ
LILNEIVNTFVKAFPAFQTELLLSHEKRGLTRSYKLFDYTSERPSAVDAYVSGEMTVEED
LDLSCKLINAPIKGRQGIYGLLQIKTPFDFAFSTAQKNYIRMLANTAGNALENASLYDQS
HRVIEDLQLVNETSRKLNGNMDSAEMIVYLRRQLLDAFKPNEIGFVFCEDMDNYRISPLS
TDFFSTDACSDYLTFVRTSMEDGEEALFEASFNSELGCSNPYESVISIPFTNQEKVIGFV
ILLHTESYFFSFDNFKLMRSLIGHSSLALANSLLRDQLQDLVNKDHLTKLYTRNYLDNAV
EESIINDQQGVFVLIDIDNFKKVNDTYGHASGDLVLKQIASYIQSEIIGIGIATRWGGEE
LALYLPSINIKAGAAIAKQLVLTIPTVTNPKVTVSVGIHSWTSESRMTFEQLFHFADEAL
YAAKNNGKNQVRFKETSSPHL
>A0A1Q9R5P8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MVAQFPPALTQALKQLVETHKVMLAARFYEQMLADPNASLILSHDEVKSRLGRSMQAWLV
KVYAAGAGDDFLPLVALQKQVGEVHARIDVPLHLVLSGARYLKKQLFQLIVEQGWAAEEH
AQILRLSSETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNITTERERQRGALLDWE
NSLMFDLAMGSSGVNLPRLAASDFGLWFRHKGAYAFQNTKESEQILAIIRHMDDQLLPQF
LAAKGDEAARMGLLREIRDQTKSLMFNLDSLFNSANELESGRDVLTRMLNRKFLPVVIGN
EITIAQKTGQSFSVLSVDIDHFKTINDTFGHDAGDLVLQQTAEILSSHSRAGDYVFRMGG
EEFLMILVDINNANALKVAEKLRRKIGEEPLNLTEGRKHRVSVSIGVATYSGHPDYQHLL
RQADQAMYQAKQGGRDRVVSYDTVAG
>A0A1V6AXY8|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MKIKSKPSEPRTPDQPEKSGKLAETIQANKQWFHAIAQQSSDIILVVNREAVVLYENDAV
ERILGFKPEERIGEKVFDHAHPDDVGFLSDAFNLLFADENAPVQQREVRVQDIEGNWHIF
EAGASHLKQKGIVEAVVVNLRDITDRKRVEEALQESEARLHEREERYRNILDNMEEVYYE
IDLKGRMTFFNSTAVRKLGYSRNEMIGMNFRQYVEKESHQKVFDAFHKVFLTGEPVQGVD
WEIISKTGVRMPVESSISLMRGLQGDPVGFRGIIRDVTERKRAEEKLHREEQRFRALADQ
SADIIVIVNRKGIIIYENNAIEKVLGYKPEERIGGGLFDLVHPDDLKYLTEIAIKIAKDI
NAPHLRSEMRIRHRDGDWRIFEVTGSSLINRGKIESGIVNLRDITERKLAEKALRDSEAR
YREREERYRNILDNMEEAYYEVDLKGNLTFFNAAAVMNLGYADNFMMGLNFREYVDDENA
NKVFEAYHKVFLTGEPIKGIDWELITKESGKIPVESSISLIRDVQAKPVGFRGIIRDITE
RKRAEEALRESEAKFRNLTETAQDAIVTTNMKGMITYANPAAKALASGKAVVGMVLKDFL
PPDSVEHHYDQIFDLLSRGFSETLSYESKIMRSPGDDPLYFDVKSSTLWNRGEPSGILLV
ARDATERKRTEEEIRLMAIIDPMTGLLNRRGFISLAEQQMKAAVRSCKKMLLFFIDLDGL
KFINDTWGHEEGDRALRRTSAILKNTFRESDIVARLGGDEFATLVYDSPELPEVIMKRLQ
CRTDEECAASDLPYIISMSIGIADYDPSVPCSIHELMYEADQLMYNQKKSKKQAGKYPV
>A0A1V6AQP6|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MTAVDKQAKQVDILKKARRFSIIPKDDPDQATRIRRFFTATAAYALNFGLSYAAYLWGMM
EWQAIAGFLVLIPAINIILYIIFRTGLNLKFRDPSLTIVQMCAAILLTMYGMYFANEARG
ILLLVYILILIFGIYKLNTRSFLYVSAFTLVTYGIDIALLSYFRSDRVNLNIEYLQWLVL
ALVLVAFSVIGGHISSLRRNLRISRTELEKSLTIIKEMSIRDDLTGVYNRRHLMELLEHE
YHRISRGGAHFSVAMLDIDHFKSVNDTHGHLTGDEVLKAVSDVIRNSLRSADFCGRYGGE
EFLLVMTQTNINGALLCAERIRSTIEQSRFTSLGPNFKVTVSLGVTEFTGKEDIPTMIAR
ADKALYHAKESGRNRVEYAD
>A0A1V6AXJ9|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MATVIEQTGRQTLLQKILHFSIIPKGDKQQAVRMRRFLMAFACYVLCSILAYISYLANIM
EWHGMIGILLICCFNNIILYIIFRTGLNLRMSDPSLTAIQMCAAVLVIMYGMYFANESRA
VLLLVYVIVLMFGIFRLDIRSFLFVSVFTLVTYGIDIILLYHFRSKDINFKMEFLQMVVF
ALVLVAISVIGGYISNLRKKLGKSLSVIREMSIRDELTGASNRRHIMEQLENERQRVSRG
GERFSIAMLDIDHFKTVNDTLGHLAGDEVLRGTSNVIRNSLRSVDLYGRFGGEEFLIIMT
QTDIEGAMICAERVRKAVEQKRFPSLGNDFKVTVSLGLTDYRKNEKIDTTIARADLALYR
AKDGGRNRVKYDSIMYPESELTILS
>A0A4R7GRW3|diguanylate cyclase|EC 2.7.7.65|Erwinia rhapontici|TrEMBL
MPDKSSRFFRPKNMVHFCFAIVFAFSSILTLHEAIVLKSSHETTQRAWLTQAGSSLERQW
QQSIDEMFFFRNMLRHALGDPLETDKSRDALTVFAGERQSPLWSISINTERSIPISGISD
AAVQRLPLLDRSDPQRLNDELTAALEMSYILQFNNPQQDFHYRLWYISRAGFYLSSVPDD
HAETATSYSSVINRPYFLSASPEQNPQRKLRWSGTYRSVDNEGDVVTVALPVDHDQYWYG
VLAMDFSTQVIQRYLQHALPRWQDGSIILFDSQQHAVAISDGQPLNEHGLDAAQVASIFS
QVTPEQSGQIRSGMQLITWMHLQNFDGLLVNVQTLHEGLRGEAGRVMMILLLMWGLFSLT
LLASHQAIIRMIGRLLTLQETLSWRANYDGLTRLLNRSAFFDHAERVSAFCERQQQPVSL
IQLDLDHFKSVNDTLGHHAGDVVLTHAAAIIAQTVRKVDVLGRVGGEEFCIVLPDTGLEE
AVEIAERIRGKLASKEVLIDATHTLKVTASLGVSSSEEQQEYQIDTLQSVADGRLYQAKA
AGRNCVSSGP
>A0A2S9Y312|diguanylate cyclase|EC 2.7.7.65|Bacillus sp. M21|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEEFSFWQKCVVGIFTGILSVLLMYFGVHIEN
IMLDLRYLAVILAIIIGGPIASSITVTIILITRLFLTEYSLASELACYTIVLIGIGVTFI
WRMKVSMFTRWIWFNVYSLFILAVPLSMLFKDMSIVALYLVCSSVAAYITFISANYVLQS
NELFQKMKQYATIDALTGLGNVRQFDLEMNHHIGNKRMKNNSLCLLLIDIDHFKSVNDTY
GHPAGDEVLKQIGRILREVSTFPDLAFRKGGEEFALLIPQKGLAYGMRMGEQVRAAVEKH
SFQLLDGTKIKITVSVGISVYEQSPEQFIQAADDALYYSKRNGRNQVSSAS
>A0A139DFJ4|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. T13-3|TrEMBL
MPRFSSEHLCSEWLAINARFTADAQRFVADFARQHAASLSEHFYQEMLADPGASQFLSND
EVQNRLGQSMQRWVAGLFAPTTEEDVFRLIAEQRKIGEVHARIGIPVHLVLRGARCLKGR
FVHLLHHTSELDENTHFAATRLASDTIDLAMEIMGHAYSVSHDRNSRAEEAYRLFAITQN
IANEKDQQRAALFDWENQLMFSQAIGTLPGELPRIQASDFGLWFRHKGIHAFEGSDEARA
VMDTMEEIDNVLLPLFGADEQSTVLGTTHVDLLKDLRDKVKSIRFHLGNLFEQNNELEAG
RDVLTRLLNRKFMPVVLGKQISQARAQKTSFAVLAIDIDYFKQVNDNHGHQAGDQVLQQL
ALILVNNSRSGDYLFRLGGEEFLLIAVDMDATRAKAMAEKLRKSVEREAFLLPDGKELQT
SISVGVACFEGHPDYQLLLRRADDALYSAKNRGRNRVVMATATDTAPQANPPG
>A0A737RDZ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sendai|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSNQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A851HU22|diguanylate cyclase|EC 2.7.7.65|Marinobacter adhaerens|TrEMBL
MPDMSLDSLSEEWQSLNAKHSSLIRQFVLDFFQDNARTLAERFYEVMLADPGASKFLSND
DVQQRLGASMQRWLSGLFVSTDREAIDTLIAQQRKVGEVHARIDIPLYLVLRGARNLKNS
VSVLLENEALSGEQRAQAFNLASDTIDLAMEIMGQSYSISHARNSRAEESYRLFSITQNI
ANEKEQQRAAVLHWENQLMFDQAIGVAETGLSPIKTSEFGLWFRHKGLHAFEGTAEAAAI
LEAMDRIDNDLLPLFGRENENTLPPAGRVTLLHELRDKVRGVLFNLDSLFEQNNELESGR
DVLTRLLNRKFMPVVFSKQVEQAMKQKTSFAVVALDIDHFKQVNDTYGHQAGDSVLQQLA
LLLVNNTRSGDYLFRLGGEEFLLLAVEVKEHHVKRLVEKLRERVERETFRLPGDETLNVT
ISAGASCFDGHPDYQRLLKRADDALYQAKSSGRNRVVIA
>A0A087DJV0|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium scardovii|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSAAATGEEGLELFTKGGIDLVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVMRRNQ
AVSESAGAVDDDIPLVCGDIAMQVGQHQVSVRGETVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRSKIEVDPAHPRYLTTVRGLGYKIDEPAE
>A0A1F2PH46|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MQNEINIFLGENITTMVILGTIVIFCLAGTIIYHLVKINNRREEWEQAEKVFQGVFNQVT
DSIVVVDKNGIIHKANETFLKYQGKPADKIIGKSIQRIPMDYVFEDEMDQLKKAIAEKGV
YERDIKFYHKSGEVIPIHLVFKPLKINSKKGREKTYMVVTGTDLKNTYEKDEYISQQKEE
LLEIQHLAHLGYWEMNYLTKKIYWSKELYSILGYEEGEVEPNLDIIYWMAYEDDQNRVWK
AFLRAFQAQEKVDTHYRIKNNRGEIRDIYLRIRHYFTKENEHLRTIGILQDVTKQVDLRE
ELNAQLIFTDKVLNNSRLLFIEFDSNFEVRNINHVVQQLSGITDDEIENKNLRDVFGNLN
RAHRKFVNENLDFRRPLPFRDYKGNIHYIQWDHATFSRRDGKNTNILLGIDVSETIEKRK
ALEAAFVQDPVTKLPNRYKLEQVLDNYFDKNGKNPDKNLALIFIHVEGIHLVGDAFGQAV
EDHLMQSLSERLYGCVGKYGLFVRRYTDQFVLFYPCDTGIKIVMEICQLISKLFDVPFVI
EENAFTLKCHIGISKFPDHANTKDDLIRFGSAAMHEAQRLGLDYYFFYDSLEKKLKSKVI
GYKQKNN
>A0A1F2PKU7|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MHNKRLLFNIVRIPIKNEALLSTEPAPPESTISLIQLNTNQINIKRISYFFFGMLIIEPF
IILLFDLKGLLQSTAQEAWIDASYFVLHLSLWLISLCWILALKQNTSKIALLLLDIDFFK
QINDQYGHLVGDQVLIHIAQMIENAVPDSFTVSRWGGEEFLVAGPMVSLEQALNLAEMIR
AQIAIETYPSTQWEITITTSLGVSLITGDCIKNFDHYFKQTDDALYQAKAYGRNRVEHSV
L
>A0A8G0X633|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MFKDEDETGQHRINEAERLRKKIIRLKQLAHKYKHAEIIQNALLEISNIATHASSLEEFY
VGVHSHLKQLIPADNFFISTLDISTGELAIPFFADEKDAHPAELYPEQSLSTLLQQGLTG
YVLRTGKALLCDNDKVNELIAAEEIVNLGSPCHLWLGVPIKHDDIVTGVLVVQTYDTNVS
YGEIELELMTFICHHISGVMERLKHQEQLEQAIQQRTRELSQAYDKLKLEVYERRRAERL
QKSLFEIAELASSSADNPDFYAQLHNVIRHLIPANNCYIALLDDTETHLTFPFYVSQLAN
KHPGTRPLQDGLTEYVLKHKRPLLLDQNSINALIASGELYSQAPELNHTQTMHQWIGIPL
FIHDQVRGALTIYSFSMTQNYQVKDLELLTFVSQHIGSAIEKKLSAESLQRSYEELEEKV
IDRTKALAELNQNLEKEIQQRRSMEAKLVHDAKHDALTGLPNRAMFMERLSHAIKHVRRH
SLEQFALLFIDLDRFKQINDTMGHLEGDKFLIETASRLKSCIRDNDTLARLGGDEFVILL
DSINNINDAKDVSERVIQKISQPYRLGTMEFNSGASIGITISGKHKVDTSESMLRNADTA
MYQAKANGKGCYVIFDDNAQHQAIQDVELETEFRHALHHAEIELSYLPVVDFNTGQVHAL
ESRLFWQHPQRGLLQQDQLSALAEQSHLTVELDKYTISIIDRTYAELLKQHDESIELHVM
LSSQHLKHKHVLRSLKNTLKQTQLNLGHLWLFFNEKALVQETENHINGFELLQKLGVKLG
ISHYGSGYSALNSLLFLPIKGLKLDANLTKQIQAEQQLKLMSAYQKTASTLELQTFVDGI
DSPEQKRIFSELGYQLGQGAALADTFTLSDTQPQSCAQLEYA
>A0A448CMB7|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MLLIGSHRVAIAEGQAQVDQIFALFDSGEAMTRESIEQNLSLLEKLISSDDIERIEKLNL
LKCWNQPFETEEDVLHSLQHIEQTMAQLPPHASPHFLTDFTLCHAWFLQQKGDINGAMSG
YTKSIQSAYEHEDIKLIADARSLRGALYSYIGDFSEALDDLVTAQGLYESLNLTGWANVN
LADIATSFRRYGDPESAIKYYNKLKEFYSQKGNKEQVANVTSDIGIALDEMGEHERAIES
FRFSYQYFKEHKYPLIAAINATNIAYSLIQLNRLNEAETYLKEAAQEITDKEPSAYSFMK
LFMAKIRYQQGRYQDALDELAAAEIAFRVMHNDRGLIQLLQLKSDIHAAMGDLPSAYQEL
QQFIALTKKVDDSSSAHQTTELKVKFDTSWIESENKRLLDNQKLKEQELALLEKNKSLQL
IILLLTGCILAIVSLFAYKQVHRNRHLQTIALTDYLTQLPNRRHIYAQAELYFQQAIKQK
TPFSVIIFDADHFKKINDNFGHEIGDQALLTIAQASQALTADRNLIGRIGGEEFLILLPN
TNAERVWELAHELQTLITRYGAINLPVELKLTVSAGVATLNTELGKQDDSFARLLKRADN
ALYDAKNAGRNCVKAAKMAD
>A0A3N0UAE0|diguanylate cyclase|EC 2.7.7.65|Lonsdalea populi|TrEMBL
MDKPASTSSAITGRITFRNALARISTLSIVITMTVSWMLITTASLISFKQYSEKNLQLLA
STLSQSIEAAVVFRDGVAARETLSNLGQQGQFSQAIVTDANGRKITFWQAAGSEHADPMS
RVIAKWLFPSSVLQPIYHRGNLVGHIEISGSDAPVKSFVYFSLLVLTLCLVFASILSVII
TRHLHHGLIMALQNIAEVVHDIRENRNFARRVPSAKIVELDVFSQDFNSLLEEIESWQEQ
ILKENDSLLKRSLHDALTGLANRTAFCSALENVLEDEESHSHTAVLFMDGNQFKSINDTY
GHAAGDKVLITIAKRLKYCAGKKDLPARLGGDEFALILSDVQDMDDVMPIVNKIRRRVSQ
PIELQNGAEVVMSLSIGVAIADQYSTIEDLLEQADKNMYLEKQKYRRHALTR
>A0A1C6GWV5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MEEKKRYNLGVLIGGVHTYFPKEHIKGISEAAAELDVNVCFFLGTRTKDFFEDVLGSKQK
NSYDYQFNTIHDYSLIGGLDGLIINYGTLGIQLREDDPNEFARKYNGITTVFLTEIVDVP
NCHSLICDNKGGIAMVISHLVEEHHLSRILFVAGPEHNTDAIERKEAYLETMKKYGLPVT
PGMIAQGDYSEFVDKQVERLLDSNPDAQAIVFANDEMAFAGYRVCEKRGLVVGKDIMITG
FDDCERASGMEPPLTTVQQDGELMGKMAVYDLVNRLDGKDPGKEAVSRRVPVSFVKRESC
GCVSEDASRKETPVGLGAQVHRLNKTIAGMKLELISFQRKSWFIPVLARDLNDCMDDEQA
FLKEIMEKMRELHTRCTHLFLLDEPIVYDGKRKWTCPYNLHLAASYENGRIVTKAAYERP
LVMKENGICDLMEDEERHQFMVFLLFSGEKQYGLLACDIDQEDFPFFYVISLQIGLSLHY
LEISKAEAARRLEMSRDMEEIKEKNRVLGIISEYDELTGLLNLRGFMEHTKRVCQAGNGQ
RAYMIYGDLDHLKEINDTWGHPAGNFALRSVAEILKGCLRSNDILGRVGGDEYIIMLECE
EADFGEKFRERVKMACKLFNEKSGKPFLVEISLGIAEFRPNISTDIQQVISLADQQLYEA
KKHRKKSVSRANNEGA
>A0A0J6BZM7|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MRRLDLRRLILGLSILSLLLALAGALYASTVVQREILLSSSLEDNRAFAQKLARGADIFL
RECLNELSYSARLIGGDGGTEQGVRREVERLKHQSERFNAAAFVNAEGIIADIMPAEPGV
IGRRISTAEMEQALASRLPRISDPFLSPGGRWIIALSQPVFLPDGRFGGFIMGLLFLHER
NALGELLGEQIHRNGSYQYVVDRRGVLLFHPNLRRVGQIVEQNPAVRAIMNSEEGAQRLL
NTEGVDMLSGYAVVRETGWGVVAQRPVDSVLARSKVLLLRTLQTSLPWLCLSLLCVWWLA
NRIARPLAQLAGAAADLDKPRVADRLSAVGAWYREAEQLKAALAAVSRKIGTKFNQLRQD
SLTDALTGLLNRRGLDEILQSEPRYGRAMAVLAVDIDHFKSINDELGHAAGDAVIRGIAA
LLRSRARASDILGRLGGEEFVVLLPNTERPQALQAAERIRAAVESFQAVPGGACTVSVGV
AVYPHEGASLTEVLARADEALYEAKRGGRNRVCDAANLAA
>A0A1C6I644|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MVKGLCRKFNALLRKEAVHENEPQRILFLLRIILLILGLYFLIIPLVFCIVGPKTEVWTG
YIFAAMSVAAFYATYRLKVHTSVLVCSSLQLAWVIVFVILYGWDCGIQHLMFEMLVLVYF
AVYNSLVYKVSYTVVLFAVRFSLFLYCRVNISVFALTETATVVLQIINTIVTFVLMAVAC
SMFSSNVESAEKKLVLYNEQLKKQAGTDPLTGLWNRRQMIQYITEKRRKEPVMAFTIGMG
DIDFFKRINDHWGHDCGDAVLVWITQHMSRELGEHAKLCRWGGEEFIFFFPDMNGDEVCL
MLNTFRMKLGNDLFDWRGEWIPVTMTFGVEENDFKSNIDTLLKNVDAKLYMGKEQGRDRV
IY
>A0A094KYD8|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR2|TrEMBL
MSFKIVRKYFDVVPLFRYKEIELKERLTLIFYMAGFGLSVIAIITTFLLGKPFWVNTPNL
LLMLSCLLLPFLYPNNFDKIVKIVLYSVAFVYLPISYYINGGHEGIGILYFLMVVIYFNF
FYEGKKLAKVIGSVLTLYVVVIIMGYIYPELITYHINDTSRIIDMIMSFVSISIVISLVS
NVIFYSYRIEKDDKEFLLKELKKQNSKLELLSTTDQLTEVYNRRYFLDALKSEFDHFELS
KIHFYVMMIDLDDFKIVNDTYGHLYGDEILKGVAKAIKSCLREHDIVARYGGEEFSVIIS
HDTLENGKTIAERIRKAVEDVKYRGKNNITVSIGIVKNKVNDTLLGIIKRSDDFLYEAKG
KGKNRVEGK
>A0A0T9TXE4|diguanylate cyclase|EC 2.7.7.65|Yersinia aldovae|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSSIFSMILPSPKTPAITLPVVLIAIISLSAVAY
LIFISKNYIDKLNLFSIIMGMLWAWQIILKYEYLGSNENNYLLLSLFMIFFISTIALSDN
FLAFCLHTAPSALTVIFLDDFQNIFRILFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLSQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVASAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLSLDIPH
VFNHKVSTTVTLSAGISPLLAYDLASSLKAADEALYRAKKDGRNKVAFAGKKLSKVELSP
>A0A378J3M9|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MKNKDIQHFKEDAKAILEAVPDLYLILCPRFNIVGASDAYLKATMLKREDILGHSVFDIF
PDNPDDTSATGVSNLRYSLNRVLEGKVSDAMAIQKYAIRRPSALGGGFEERHWSAINCPI
LDQANRVKYIIHRVVDVTTFIHQQSHDDQSKIMEILQGHEGQVGWEIMERANNLQEVNKT
LQEREGYNSAFLSAIPDAMILVNRDGKIEFSNTQAEVMFGYTKKELLGQAVELLMPENAA
KIHPQHREDYFNAPRVRPMGLGMELQGKRKNGDIFIIEISLSPLQTPQGGSAIAIIRDVT
LRVEQNKLLQQKEKSLRELYETVEKEKSQLKSINQKMFIITQLSETFLACNTIDEILESF
SSFANKILGFSKGALYLMHNSRNYLEKKITWDDVNHYPVIFSSNECWALRRGCIHEVSEV
QPGVVCRHIKEMKQEQQASLCIPLMAQNEILGLLLINRDSDEQNTLIPVVAETVSLAIAN
IRLKELLHSQSIRDPLTGLLNRRFLDEFMIKQIGQAKRTKTSLVFIMVDIDNFKAINDSF
GHEIGDYVLSRLGNLLPSLVREGDLACRYGGEEFLIVIPNCDAKNAKLFAEKIRNKVSRM
RIVIEERVSNIAISLGVAIYPGDGSSLKELVDAADQALYAAKRQGKNKTIIFTEINK
>A0A097R7Q7|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei FB1|TrEMBL
MSDIPATPQCSRRFTPQRIINICFFAVFIFTSLLFWRQGQVLNNGYQASQLNRLENVSAQ
LGSRMQFRLDNLLFLRNYMRYMLSQPIMPEQKRLLEAEMATLRVQDIWQTGHSHSASPPL
NGIGDSQIGLLPSSDRPDNDLWLTEINAAMRLKALLPLTNLNQALQPRIYYISRSGFYLS
STPPRDKSLISGLYTHMLARPYFPMAAPEANPHRKAFWSRMFDNQQDGMLISATAPVDYG
DRWWGILGMDFSIKRLNYYLQEALPSHPHSVFMLYDSHFEPITSSDPNWRRGKYFSEAQR
LSLQKAVLKQSEGTTRIGTSFVTFTRMENPNITLISLQSLPQGLQDQYGRISLTLVALWC
LFVITLIGTHYVISRLVRNMETLQNRLSWRAEHDPLTELLNRRGFFDKAEEITRKGQCYG
RSMAIIQVDLDKFKNINDVYGHHVGDLALKHAADTMTSMLRKQDIIGRIGGEEFCIMLPN
TVLSEAVAIAERIHTQFNRQNLMLSDGRTVEVTASMGVSACSGTTGYSIESLQSQADKRL
YRAKTAGRNQVCASDKDA
>A0A5B9TRA4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum multivorans|TrEMBL
MMDQETLYKLVIVVLIIGILLLLYYYQKRLCELKLHNGQLELLSQYDDLTQIYNRRYFLE
IVQYHFTKMYHQKPSAIMMIDIDHFKQINDTHGHILGDDVLQYVVKLISEHLRESDIFAR
YGGDEFIVFFPAISQKDIYNIALRIQSKLFEDSSYASPVTLSIGICLFSTSLALQNVIEY
ADNALYSAKSKGRNRIEFYPS
>A0A4Y6RVM1|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. PHM005|TrEMBL
MIKVRTNSIVARSVNDEKICALNELQRNIAHHYQWSLNLNRTLVCGTPPKDDTLREDAHC
RCKLGRWLNGRGKQYFQNHPRFNTIIEHHKEMHDLARELANSAMREEKISEKAYDAYQDA
QSRLRDEIQATHKELHDEIVSTDPLTGAETRTTMQERLNERISSAKYGQIQDWLIMMDLD
HFKAVNDTYGHATGDVVLTAVAATVRRQIRANDLFFRYGGEEFLLCISNVDESKMQEISD
RIRKSIELTLIKATDGACLSVTASFGVFGLTPDVSVEEAINKADKALYEAKNAGRNCVRF
FYDQNYLTAAAATG
>A0A239LEU4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas japonica|TrEMBL
MPSVSPELQAREWHSLVAQFPRALTRALQSLVESHKVTLAARFYEHMLADPNASLILSHD
EVKSRLGSSMQAWLVKVYSASAEDDFLPLVALQKQVGEVHARIDVPLHLVLSGARHLKKQ
LFQLIVEQGWAAEEHAQILRLSSETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNI
TTERERQRGALLDWENSLMFDLAMGSNGVNLPRLAASDFGLWFRHKGAYAFQNTKQSEQI
LSIVRNMDDELLPMFLAAGEEQRMSVLREIRDQTKSLMFNLDSLFNTANELESGRDVLTR
MLNRKFLPVVIGNEITIAQKSAQGFSVLAVDIDRFKYINDTFGHDAGDLILQQTAEILSS
HSRAGDYVFRMGGEEFLMILVDINHANALKVAEKLRRQVEAEPLNLTEGRRHPVTVSIGV
ATYNGHPDYQHLLRQADQAMYQAKQGGRNRVVSYEAVAG
>A0A7Y7I3P5|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SG517|TrEMBL
MEFLIEQLSESVSSAKTLEDLARPMLEMLEAATGLESAYLAIIEPDKARQHILFAHNTGE
LAIPEGAYVPWGDTLCRHALEENRIYADDAGGCWGDADAARELGIQSCASVPVNIDDGGL
HGSLCVASARQVPLPAIAEPVLRLFAKLIGQQVERERMIAKLDKAGIELSANAATDVLTG
LPNRRALVDALQRMLAQGARSAQSVLVGFIDMDDFKKINDAHGHAVGDEFLAAMAKQLSS
CVRASDMLARFGSDEFVVIGLGPGLGESPRTGAMALGDRLAENTKGELKLRNMTIDYAGA
SVGVVAVDPRTTSAEEALRQADAAMYAVKHSRRAMAHDAGALLPG
>A0A8E6NMG9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000540|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7R6WA79|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MCKAKILVVDDERFFTNLLYDILKDKYHVSVVNSGTAALEKIQQQHFDLVLLDILMPDID
GYEVCRQIKLLEHGHNVAVIFLSVKNDEQDELTGFKLGAVDYITKPISLPIVLARVATQV
ALVNAQTQLRQHSADLELLVSKRTAELNREITKKQKAYEKLHYLANYDQLTQLPNRNLFN
ERLAYAYKLAKRNKTQFSLLLIDLDRFKQVNDSLGHHIGDLLLEQVGVRLSACLRGVDTI
ARLGGDEFTVILTEITKKQDAAIVAEKILESLGEPFNVNGQTIHIGASIGIASYPEDGED
FSCMLKNADLAMYEVKEKGKNAYAFFSAGLTIYVKQRMELDKDLRHALINEELYLQYQPI
IDLSNNAICGVEALLRWHHPKYSNVATEEIISIAEDSDLILELGEWVLTSACRQFSEWRQ
QGLDNLHIAINMSTRQFCYKADSNGMVAKLIQQFQIPADALQLEITESLMLEDSEFTVDV
LQKLKQLGLAFSVDDFGTGYSSLGYLRRFPIDILKIDKSFIQDLPLDSGSDALVKAIIAM
AQCLNLRVIAEGVETQQQLEFLQRHGCDMVQGYYFSRPVSAAKFELLMAQQQKLSSV
>Q8EHG6|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MIIVGFIGLVLVIILSAVLSLLRARSEALRQQQQFLAQLCPQLERQKTDRSPLNIPVVPQ
ECEPLYHALNEMLAALPAGMGKDKLTGLINRVGLKRTLASLMPITQGTLVLIDIYRFRYV
NDLLGFVFGDILLKQFAERLTSLSLKPKLIARLNGDEFFLYYEQSLSQEQLLHLRGRLQV
PFNIKDTPVSVRLQIGCLQLAQHHADVSNMLRRLDLALKKARSTRIAIACYSENDDIRQL
RELKIIDSLPNGLQRNHLYMVYQPKQDVSSEGCTQVEALIRWEHEELGVISPGEFIPLAE
CAGMIDLVSHWALEQVLQQQVKWRLAGISVCVALNLSTRDLDSETLPHELDARLKHYQLP
PECLMIEITESTLMADLNKAVDTLVQIRRLGIHLAIDDFGTGHSSLAYLKHLPANEVKID
KVFLQDLKPNQPSEYILEASVNIAKKLGYEVTVEGVETQEVRDLLVKMGVDRIQGLCYAK
PMRAVELEMHWHRLCPAPKMLSANLGSHP
>A0A1V6DBD6|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium ADurb.Bin126|TrEMBL
MVIVTAAVAAGPLVRRSTNKRSTWLAIVFGIGLALVPSAVNLLQTSGLWKPTPHFAVLSR
LDALGFALILFGVAMSLRAASRSGEELRKQNAVLQQEASTDYLTGLLNRRQVGLLLDYGA
ARARRSGDALGFIMIDLDHFKNVNDTWGHQAGDAVLVHVARLLQRRMRASDMIARYGGEE
FLVVLSDPNPDGIVTIADDLRRLVEQNSAEFGGQSIPITASFGVSVSLVNTEEAVQESIG
RADAALYAAKAMGRNRVVGWDQAFHEGDDAVRDHIKTADVASAPTFKIA
>Q325L3|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A7I6S1G3|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP4-W18-ESBL-05|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLIDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKIAAPDGSDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A8F9WNK0|diguanylate cyclase|EC 2.7.7.65|Mycobacterium pallens|TrEMBL
MVTASRGWTAPLGVALTTLFGLALVGRDPLCSDVTGLEHTGGASAMVIHAATQPGPRPDP
SDAAVMVDAVLDRAIVALDATGRVLRWSAGAQLMFGYVEGEIVGSPMSRTYTQHDQRAGV
AERELSAAEKSGRFEAEGWRVRKDGGHFQAGVVISALRLPDGSIKGFTEVITDLAADQQR
AHSMFYDLLEAAPDAMVIIGTDGRITLANAQTDRMFGYQREELIGSEIEMLLPARYRADH
RRHRTRFLAAPTLRQMGSGLDLWGLRRDSSEFPVDISLSPLRIGETLHVSAAIRDVTERH
ESEQQLRHQHQELIKMQEELQRLARLDTLTGLVNHAETITRLEAALRDHQIPAAHLGLLY
CDLDRFKAINDTWGHPVGDVVLSTVAARVRDCLRQGDTVGRAGGDEILVVLPGVQSMEVL
TTLADKIREHVAEPIHHLGHIINATVSIGAALAVPGESVTDIITRADAAMYTAKKAGRNQ
VTS
>Q8EFD2|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MSSPAANKELDASAQILRLAVPQMSALDIPVTPENYTVWYEYFAQSNLDLNRAIDGFLAN
NVVFTKEVNTSLYKNFIQEKSPEVIENVQIETQILINSLISKITQLNQGTEAFSNTLADF
GLQLQSSPDVNTLNQLVDGVIDEMQNLLVNNQTMEQSLNAMGQEVQNLKTEMENLSLAAM
TDQLTSLHNRRAYEIAIQDHIHRAEEQHTRCSLLLIDIDRFKVFNDTYGHQVGDKVLAYV
ALALKQCVRGDDFVARYGGEEFVVLLPNTHFHDALQVAETLRGRISERRLAIGKDKKLSL
GAITVSIGLASLQKGDDAETLFSRADKALYEAKSDGRNCVRG
>Q8EKF3|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MPSTLQHLSLKQKLILFSLLPLLMMSIFVLSRMYMLVKEYRFANQNHLAIRATVQTTDFL
FQLHNEYGLSTQLLPATTPQDETRLLQQQQITSAALEALLKSPALIELNATLSDQQASTQ
LQEKLTNLTLLSHKLASSRQEALDQHPSSFIVLYQQFNSSLLQLVQQLQLLTNDITQSRA
YADLLNLLMVQELAVKERSAINRMLLSDSLSINDYKAINTIMYEYGQAISHASNASISDR
HSLIRQIQASPESLRILKISQQIEQQIHISTLVQSINAHLGYEGLIDSFQDYLLTGSPAS
LAKFTKALTTIQQKLDELNRETVNLPSLAPAVQSIEESINQYQFCMSKIVQLKDQKLSLA
EITALAHINNSELSAAIDKLLMPPHPVSSKHWWTLTTDRINKLNALSNEITLSMARQSDI
QQHHALMLLGIYLLSALFTATITLWLGRKIIRSFMFKITQIANDMQQMAADPQLNIHIDV
SGSDELARMSRAMNRMLSERQKANQALSRAAAVFNYSAEGIMVTDADNHIELVNPAFSQI
TGYSLEDVKGRSPSMLSSKRHPSHFYTAMWEALQKDSKWEGEIWNKRKDGQVYPEYLAIT
VVRNERGEIIQHIGLFMDISKRKQYEQDLWYQAHFDTLTGLPNRKLFNERLQHEIQLAQH
DSRKLAILLIDLDQFKYINDVQGHATGDLLLQDVAKRLENIAGKNDLIARIGGDEFVLIL
PRVTNEFAIEHMASRIIETLSTPFNLNEREIQISASFGIGVYPEDGLDVSSLTRNTEMAM
YQAKDAGRNNFKYFTSGMNQAMFARMELEQRLRRAVAQDEFTLHYQPIVEMKTGKVCSVE
ALIRWQDPDLGLIPPDQFIGIAEETGLIEPMGEWVLNQAMHDLRQWQQLGLQLNVAINVS
SRQCVNARGMGFDQVLQECFNRHHINPRNVHIEITESMLMGDASHCLSTLEAIRRLGSQI
YIDDFGTGYSSLSYLKKFPISVIKIDRSFVENALSNNSNTNLVKAIVMMGQSLEMELVAE
GIETEAQWNLLRDLGCHYAQGYLISKPLPFAAITPLLSQTLPRLLQPQAPREKCVNA
>Q8E9T3|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MTSKLSLNAINNCYLDNFVWIGPCHQHPWHPEFETFNSVEALLEQGRTVELIVLSLQAEE
QDKCLRALRKNDSTFLSHILVCHESALSPYLANGLWDAGYDECYQIYQLKKKQIKLDYHD
DPRYKLLTYLWCHENTILEPHSVPEKTYLYDYPLLRCFGINPEESFAWLGELQKSQLIEK
AELSNRLRFCPSCHSGHLNYIDVCPQCHSIDTELQSSLHCFNCGHVGAQASFRKLNTLSC
PNCLQSLRHIGVDYDRPIENQHCNSCQTLFVDAVVEAKCLHCQVSSKLNDLHVRNVYSFK
LAITGRTLVRQGRSLSWFALEPGEQMTSAQFYWLLDWQNKLAKRHHQTHSILSIQMLNVD
EFLRAEGEAKGFAQLDALQDRLRSVIRVTDACSNYTRDGLLMLLPMTEMSQLNSIYKKLF
DLKELQSTSKIEFSVKALTLPAEIGENVAEWLTDQLVKAKPI
>A0A7I6S0E0|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP4-W18-ESBL-05|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNALLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYLAKQNGRNQVCTED
>A0A345C7A1|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. W17|TrEMBL
MNKEFTSAPRPTFKRTLRRISIISVLITMTLVWLLLSIASVFTLKQYAQRNLELTSATVS
RSLEATLVFNDTAAAHEALATLGKQGQFSSAILLDRHDNPFAAWSMEPDVQADPLSQLVS
QWLFPQPIRQRVWHNNLPIGELRLTARDSLISHFLWTSLAVLTGCILFASLVALAITRTL
HNGVVTALQNITEVVHDVRTNRNFSRRVPEERIDEFHRFGQDFNSLLDEMEEWQRKLQAK
NAQLLRTAMHDPLTGLANRAAFRTRISALMSDASSRANTALLFLDCDDFKLINDTWGHAA
GDDVLIEVARRMVEFSGGRHQPYRLGGDEFAIILYGVHSEYEVLRLCAELTQQFSPSYDL
QNGLSTRMSLSIGFALSWQHHSVEALLDQADRNMYLVKHQRPRNSA
>A0A6G7TG96|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 29361|TrEMBL
MNKKYQRVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTFLAPLWFPTAIMMVAFYRH
AGKMWPGIALACTLGNICASGLIFSWESLNLWFAGINIAEAFVGALLLRKLLPSYNPLQN
LGDWIRLAIGSAVIPPLLGGVLIYLLVPNDEPVRSFLVWVLSESIGSLALVPLGLLFKPH
YLLRHRNPRLLFETLLTMVVTLILSWIALQFLPWPFTAIIVLLMWSAVRLPRLEAFLVFL
VTVMMVSLMIAKNPTSLVTQNASVMINAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSVIGMALVSTDGQWLQANKALCQFLGYSQSELRALNFQQLTWPEDLESDL
EQLDQLLKGEINSYSLEKRYYTRNGEVVWALLAVSLVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDVKPNVISWDKRMFEMYEVPAHVKPTWQLWHECML
PEDRALAEQVVRDSLAARIPFKLEFRIRVKDGIRHIRALANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVNMNVTFMNPVAEKMSGWLQQDALGQPI
LSVLHITFGDNGPLMENIHSGDMSRTDIEQDVVLHSRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRELSYNASHDALTHLANRVSFESYLKRMLHTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDMLARLGGDEFGLLLPDCNTESARYI
AGRIIDAINEYHFMWEGRLHRIGASAGITQIDERNNQASEVMSQADIACYSSKNNGRGVV
TVYEPQQERMHNAPGTISLDEQWHMIKDNHLLMIARSVASPRVPESSTFWMLALRLWTND
GEMLEEQAFRAGLAEPELIHALDRRILQEFFRNFATPLTSKGTGVALPLSMAGLASATLV
DELLEMLSASPLQPRLLHLVVHVSVLTLEDEHSRNNLDKLRQAGCRIILSHVGRDMEVFN
HLSAQMADYLLLDPELVINVHGNLMDEMLVTIIQGHAQRLGIKTIAGPSNQPIMMDTLSG
IGIDYIFGNTIGEPQPLELLLNTSYFGIN
>A0A0T9NCX8|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MFCVGSVLYTQNAPLWLWFMLALNGLVWPHISYLLATRSEQPFEQEIINMKIDSALGGVW
VAIMSFNALPSVVILSMMSMNNIASGGKNVFCKGLALQIACSLLTAWIFNLPFKPETSPL
QVYACLPMIIIYPSLLGLVTYRTAKRLAENKEELLRISVRDGLTGLYNRRHWEHQLHNQF
DSCRRYQQGATLILLDIDNFKSINDTFGHAVGDEAITVLAEELLLGLRAIDIVGRYGGDE
FGAILPNTTAEQTREVLMRIQEKLADLVFTHAPSLQLRVSAGIADYRHDMINYQQWLKAA
DSALYLAKDNGRNRIELAS
>A0A5H7S6S7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Wentworth|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V5VJI0|diguanylate cyclase|EC 2.7.7.65|Elusimicrobia bacterium ADurb.Bin231|TrEMBL
MRILYIEDNAEDVVILKKTLKETGERINLFIAETLSSGIEYIKKEDIDVILLDLSLPDGN
GMESLYKIQHNASLPIVIISGLDNEEIAIHAVHEGAQDYIVKEELNGKFLLHILRYAIER
HGLLQKLRSLSLIDELTGLYNRRGFMHIAEHQLKLVQRLKKKMLLVFADVDGLEHINKTW
GHKEGDLALLDIAKVLRETFRYEDIIVKLKGDEFVALVLETSDYNTETTTTRLQQNLDAA
NEKGHRKYLLSLSFGIVVFDPEEPCSIDKLLERADKLMVKQKFEKNNHNSKIKN
>A0A379BYU6|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MAEGRSLVQSWWHDRAGYDWLTDVLGIHSALRYVRTMIGAGGAVMCLVTAVSLISNIGPR
NTWFAIGCWLIVGLTALWALRWWLLPWPSRVEALLWCAGADLAITFGALAAEHRVYGALV
STLMVVVGMFVIFQGPLVLALHVCWSLLSGLVLVVLLVIDDPVHTGVAAGDVRLASAIML
ILLALNVVGLPTVQFCHWLWRQHALLDPLTMLLNRRGLDYHLSYVFRPETAEYAYMAALD
LDRFKTVNDTFGHSFGDEVLVRTAERLRSTADPDAIVARTGGEEFVVLGRLRDEPLAAVA
ERLRGAIETMPGLPVAVTASVGAALCPITALRDPAVARYTLHRCDFAMYEAKRLGGNIVA
FEDPESADSVAADERNPLCRRAITPS
>A0A3Z2F630|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain ATCC 68169 / UK-1)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5P9EEN2|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MQPEQPERGKETGWSSSQSPLRRALSATLVYLVAGIIWITFSDRMVEIWFADPRSLSAMQ
TWKGFLFVVVTALVLFTVMLRLLSKDRLLLSLQLDQRRALRQREQQLRVLMDNLPGMAYR
CRNDDSWTMLFVSGGCEPLTGYLPDDLINNKLVSYASLMDPDAIEQVSEEVAIAVRKGRS
FSLEYAITRKDGRKVWVWERGCGVEHDDGSVFLEGIVLDISDRKQLETELEEMATRDPLT
GLLNRREFSRVLEEELERARRYERPMALLWIDFDHFKDINDSWGHAAGDTVLCAVSEILT
DRVRSVDSVGRFGGEEFVIVLPEMDVEGARDTAERLRQRVGNAPIPLESGHSVPLTISVG
VAVYPVHGHTVDTLCSAADKAMYQAKMQGRNCVAMAQPIEPVHNET
>A0A828RDK7|diguanylate cyclase|EC 2.7.7.65|Limosilactobacillus reuteri MM4-1A|TrEMBL
MIISQIYFERYWVSYKNSRLTSWGLGAVIIITYFIQEFCLFQLSLFNIGQVVFMQVVSVT
MLFRDKVYKIWWALLALTPLFVNVVEYLMGILPLKDWWYWIVESIVFTTICLALTRWCKI
SKRISYFYAIASLGIVELVSLAITRSFSPVSIAAATLGLFVIAMFEDQRFYSEKKNEQKI
KLLEKESERDDLTGLLNYRALSQEINRLANNNEIHNIVIGALDIDHFKKINDTYGHFVGN
EVLNYFSTVFREQIHSAFPKHGYVYRFGGEEFTIVVSNHSLEEVYQLLQSIEKFFNNKSI
VTKEGMKLTISFSCSLTDRLNDELLDTTLKRADKMLYSVKNNGRGWIVTDQHHQRPQKPS
LERKINNNY
>A0A1E2RUV9|diguanylate cyclase|EC 2.7.7.65|Methyloligella halotolerans|TrEMBL
MRPNSMLSMATLNKNGHWFAFAFLGLLICAIAFFAPARVSKMQLEREAQTAASRISEQIT
DEPGYLFDSLAKRSLAPRVGELLEQMGYGPRVLRYEIYDKDGQLVFTSGNSAFDLTPDLE
ASDAETATGDASPYSSIKLYQGGGLGAPDYFAALSIPIKLGGQPEGKLTVYLDQSEQARV
LAEYFGLIAVVTMLLLAVGIAAPVAFAWMRSKERYQAEEQLRFLKDHDALTGLPNRAAFT
RLLSDALNHMHRNRTHIAVLCVDVDKFKEINDSLDHAGGDVVLREIATRIGTTIRKGDLF
GRLGGDEFAVALVEITNLAT
>A0A379Z0R1|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MLIPDTLKDPRFADNPLVTGAPHIRFYAGYPLTMRNGCRVGTFCIIDVRPRELSQEDKLC
LEDLGRMVENELQHMEEVCQDELTGVANRRGFELLGEMALSSCCRESFYGALLYLDLNEF
KPINDTYGHSEGDAVLQAFAAMLVSCFRESDVVARLGGDEFAVLLTHLRPLDVRAIKLRF
RKALAELNFRLAKPYQIRASLGEALYDPAQPRSLAELMAQADGLMYRRKPGRD
>A0A0Q0GLX4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MSENSNAVDKKLKQAIEARIAIENARKLQVDTLSNLTAKLSLSCKGLDIELDNKLAKFRN
SLNKGVGFEVLSPLIDDILLLLQNQETLQAAHQRELFSSVQTAGKLLQKTKGLPDDTRRT
LRHLLDHEINNVQSTHDYIPILNQLINFYHHALQSKLSATDETSVNASPRMAKKLLELAN
ELVLEDESTEQIKQIKNAITENDNVEALLQAALNIISVVVKNISKERQSAQSFLVSLNQT
LEELHSSIVSTSQHSKSMGEEFDTLNKRIEGKIKHLNEQTQSATSISSLKELVDNELRSL
SKDFIAKEQLERKDRETLIASFDEINDRIGSLEGKLTKYKKRLNEQRFKSLLDSLTKLPN
RAAFDERYNHELHLFNVQASDVTLVVIDVDHFKSINDRFGHTAGDITLQVIAKALQKSVR
QSDFIARYGGEEFVLLMPGLSLSHAAQPLEKLRKVIKNIPFKFREKEIEITISLGATQFK
KGDTPLKAFDRADDALYEAKKTGRDRLCMSK
>A0A6I2IHF6|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT711|TrEMBL
MNRFRLPMAKTLRVIHLVFIFVFALTTFLFWQQGQLFSHGYRTSQLSHLESVIARIESKA
QYKVDNLRYLKRIFIEAMDDPLFPGVANVPSEITGDVGDSPLWVRELPLPDTLTEDSAFH
GEDALQVRQQLYALRKIQGLFPLATGANELTADLYYISRDGEFIVSLSQEMNSLLVSSYN
PHVEQGSFVLASPLLNPQREPFWTRQNIAKTDDTLVNAAIPVDFRGEWIGLLGIAFENDA
VQKFLAASLPEDTQSAYQLFDERLIPLTGTVGSANQFQLTAKHLQTIRQMLEVSSRGTMR
DGSVFITFGRVVGTRSVLISTQTLSQGLHEDFGRFSILLIAMWGIFVLFLWGSHRVICRL
VLNMGSLQREMQHHALHDDLTGALNRRGFFEKTSQISPDYVDYTLVQLDLDHFKKVNDVY
GHQVGDNVLVHATQRIQRAIRSQDILGRIGGEEFCIFLPNSDLKAGIMVATRIKWELESS
PLLLDDGTQLQITASLGVAAYSELPECSLEQIQSLADMRMYTAKERGRNQVCWQDDDAI
>A0A6N3GVJ4|diguanylate cyclase|EC 2.7.7.65|Clostridium tertium|TrEMBL
MEKFLYAEINTIGLAILATIYMKGRNITKSDLSQKMFNYLLYVTASLLVFDAAMRCLDGL
VFEAANEILLYTTTIYYILTVAMVSVLLMYCDSKVYVSDGKQKLRFKIYMIPFYINAILS
VISFTTEWIFRIDENNVYHRGELYWIHVLIIFIPLLYSIRMIIKGMKDCSEVKRNEFRYL
ILFLLSPVIGFIIQTFCYGLSIAHICCVISLLITFINIQSNLIIMDPLTQVNNRRAFIDY
IKCKISKVPDECVLFLLMIDVDYFKKINDEFGHTVGDEALVLIVRGINLACTRNDFLSRI
GGDEFAVVGQRRNEEEIKALILEIERKIEEVSIQENTEYKLSVSIGYSIYGRDGIIEISD
FINVADKNMYEVKKAKKIKA
>A0A841KC49|diguanylate cyclase|EC 2.7.7.65|Oleiagrimonas soli|TrEMBL
MSYEIINKRQNALRYVEQTYHMRMLGLALGIFPVAAVLHAHHAPMWQWILLVVYALLWPQ
AAYLMARASRAPDQTEFRSTLVDALVAGLWLALIHFNALPSLSILMIAGMALVSSGGWRL
MVPGIFLLLLGCLFGVLLDGFHWFPRTSDTVILATIPLLVVYPVAVSSATYRLARRVGRQ
NQLLSQLSRTDSLTSLANRHHWQESLALEFQRYLRTHRPATLVMLDLDAFKSLNDSYGHT
VGDDVLRRVADILHENSRNIDTPGRFGGDEFGLVMPETDRDGARMLMERIRREVEREVFD
VDASLRVTISIGLAEITRGMSDPLDWIKAADDALYLAKEQGRNRVCTAPYAASAGSAS
>A0A8F9SP70|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MLKELFLNLTILITFNYLFTLLFKESLSYKEDRPMFQLLKGTVCGLLGVFLIVFGFSYSD
SIIDLRNIPIIIAALYGGWVSTASAFAIIVAGRILINFNASAIFSIAAVGVIAILSAAVL
RGKKPDHKKAFVMLLFSNVIFTLTLLFLMPEQPAGALVYYWLISILGGMLSLYIIKHEAD
ARVLFKQYKFQANYDFLTGIFNKRKFEDVSRVLYDRASQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSHTSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTPDPQTLPLIADRMLYKAKTSGRNQVCSTEKEE
>I2UFV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 4.0522|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3P8KY00|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTVSIGVADRQDDEEIDQLFNRVDKALYAAKKEGRNRVRLYLVEKY
>A0A3P8M3E5|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MQNGKDALTSLLNRRYLPVVLKHEVTLAIEYERPMTVAIVDIDHFKEINDSWGHQVGDRA
IKHVADLLGDNIRSSDYIFRYGGEEFLLVLVETGAHEAHVLLERLRKNISQLAFNVGGET
EIAITASIGYAIHTGHPDYNLLLRDADSALYAAKRDGRNCVKMHEGGSGG
>A0A7Z9CUV9|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MISAFLSLASPLFTVVRFTLPCTLIFACSAGLLLWHWKFARRRINISFISLIFGLLWAWH
VCEKSSMMPPPHFNFLVIALLSVLFIGAIAFSNNIIAFTLHSFPTFIACLILAEGEQWLR
MLYCFMLPIAGITMQNLIQKRSDTFTQGLMDKLLKERNTLNDLSMLDPLTGLYNRRGLQN
RLDTLLALDGNSHHVLLLDIDHFKAYNDHYGHMMGDQALIQVSAAIRNAVRSRDIVARFG
GEEFMVLLTNSTAETAQQAAERIRQRVYDLKIAHMFNESVATNVTISIGLTPLVDADIDG
ALKRADSALYEAKKLGRNIILAS
>A0A399EF45|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MLAPELVLCAIALGFGFALLRAARRRPVWQGAAWGLLLWSLEELAWWVQRSEGFTAAVTP
ADALFYAGAASWMTTLIRLEARDTPRWGLLIVPALGLCAAALLARPSALLSAVVSSLDLL
LLIFALPVLEPALRGQASVGRLLLGLGIFFRVSVHSAYYWLGEPALGLLDFGMWGGSYAL
MGLGAYLEARELERRARFWPYLLGVASSLGVYLLFLQAASVLRASMLVEAALLAAYPLLV
IVLAFLGVLYRDRRRAEERLGRWLALLERLGELEAGVHSTQTLGAPALMKRVLEALQPVF
PDLVGIEIRNREAVRVGKAALYVKHFPLYADDDAEGRLYFERTPSPSDAHDLEVLGPFVS
EKLRSALSLEQWRHRALTDPLTGLLNRRGLERQIPRLIDLCHKNQRPLSVAMLDLDHFKR
INDTYGHPVGDRVLQALAGVLRRHLRTEDLAVRWGGEEFALLLYGAGLEEARRVLERVRA
ELGALDIEPIPWNVTLSAGLTGGSVPSSEGLLEAWILQADWTLLHAKEAGRDRVMVSEPP
RSPDAEPRGTAAS
>A0A1S8LV13|diguanylate cyclase|EC 2.7.7.65|Clostridium roseum|TrEMBL
MNILSMLSFTNFILFVRGALYSFGHIRKSKLALPFMLVFTSLAIWCFGDTFFYTAPTIAN
AIFWYKLAGIGWVTFPATALHFFLLLTKFINKSKQKKIIIAIYIIPIIFLTKNIFSSKLL
LAVTIIKNPAGFGWTDIGSNDLWFWSYSAYLITFIVYGLVLVYKWGKLSPYFSEKRQAWA
LLIVSSITLIIGVYTDILAPTIGIRLPPISNIIIVLLAITGFVAIQRYNLFSDANTVTAE
TILNTIKDPVLVFDANYKIIKINKATTDLLGYTFKQIEHKELSYILANSDYDEFKKKLFL
SNKPFKYQEATLLTSDCRLISTIYSTSVAKNKYNEFLGYIITFKDITDRKAIENQLRISN
YKYKKLVFNLFKAANYDLLTGLPNRRVFFSKLSKLANSYKRHKQDFVVIYMDLNGFKQIN
DNYGHDIGDYILKTAANRLKDCIKKPEILSRLGGDEFVILIPNSPSKLIIDDKINMIRKN
FEANIKVGEKSLNIGISIGYSTFAICNENINTLVKTADSKMYSDKLKNKNIRV
>A0A1A8Y242|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MYSFSHPSAGQRRRFLLVGGSYVVLWIAIWHTAGLLDQNSVSLWYLPAGLRFCCLLLFGW
RGLLLELLANMACGLLQIPIPTDLPAAFLSAQPHWLIYGWFAPVFAYAVVLLPWRRLKHD
ALDFARPADVALFILAALAASTLAASAGTFRLAHVGFIPQAQWPEVLANWLIGDFIGIIV
LAPFLMVRVWPGLQHYLQTGHWAHFRKPRNGNGDSDLHTVLIAVSALLLVFGIPWSWGLN
THFPLIALLLLLPLAGLALRHGLRSAVLAAALLDCGLVMLIALYGQFGLALQYQIVMIAI
ALVGLWLGGAVDAHKRITLRYRDFASISNDLLWEADAAGRLSEASGRLAQDAALSPGQYW
RDLLSASSQPQLMALEHALSEQQLFHHQEVLLKGAGDSPIWVKINGLPLRDDSGRLTGYR
GTAVDITRSRRAEAVLHNYNEELLREVAERTRELAQSNSELATKELHLQVLLAAAPVGVL
ELDDAQCCRFINVNGCAMIGYAQEEAQGRPVLDFVLPDDHDYVEFVLKINRQNDAVHWLE
FRLARTGLRCSAHCLNLGGSDKPDQPMSGMIMVLTNATARSQQDERLWTLAHYDALTDLP
NRILFWDRVEQALRHAKRLDSGAAMLWIDLDGFKGVNDHLGHAVGDALLQQVAQRLKGRI
RDSDTLARMGGDEFAVIMPGITASESASHVATELVASLAEPFDLPQGTAHISGSIGVGLY
PQHADSVESLTQCADMAMYSAKTSGKNQVQVWKD
>A0A4P6WSL4|diguanylate cyclase|EC 2.7.7.65|Citrobacter arsenatis|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGETLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGALLWVLLPKETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLNNDL
EQLDMLARGEIDSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYELPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARGQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEVMEEQTLRARLVDPTLNQVLDRRVFSEFFQNAAPAVASKGLSIAVPLSAAGLLNSELI
DELLEQLQRSPLPPRLLHLTVPASVIKTNPTQAASALHRLRQFGCRIVLSQVGRDLELFD
NLKYHMVDYLLLDSELSASVHGDLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A4U6H392|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls714|TrEMBL
MEQVAPVNDTLLLTEWQALLRQTSPEVHTILTSLSDEEIRHLVSVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSANEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKAEYSPALLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDRENQFIYNIATGMPFGELVLLANSDFGMWFAHKGKYILGNSNLL
KEMESLIAEIDNRLTTTLSHQHQATEPERMSLLQDIRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASATEVFSV
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIFQE
>A0A679JG17|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MESLIEQLSDSVSSAKTLEDLARPMLEMLETVTGLESTYLTTIDLDKGEQHILFARNVRQ
LTIPEGLSVPWADTLCKRAMEEGRTYTADVAGCWGDSDAARQLGIQTYVSTPVRTEGSGL
FGTLCAASATQQPLAPHAEPVLQLFARLIGQQVERELLFMKLEKAHAELAAVAATDALTG
LPNRRTLIENLRRLLAQGERDGRSVLVGFIDMDGFKKINDTHGHDIGDEFLSAMAGRLSA
SLRSADMLARFGGDEFVVVGAGPAFDESPRTAARALADRLGESTIGELRLNRTAFEYGGA
SVGVVAVDPRTTSAEEALRLADDAMYVVKRSRRAVANDRETSST
>A0A3N6H0D3|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI98-12|TrEMBL
METESEPYVRLATLRQLHQVVADLNTARSLADTLQTVADGAVTGLGYEICAVNLVQADGD
LVVAAVAGNSSAEALLAGQVGPRHAWEHRLSIAEHWGDLRFISHTEAWALDEDGVPGWYT
PAPAPRFEDEWHPGDRLFAPLHATGGDELLGVISVDRPRNGRLPGPWGQEAFQMYAFQAA
IAISNARLRANMQRALVRLEREQQALRASEESFRQAFEFAPSGMAIAEMGGDQHGRILRA
NDALCRLLGRRANTLRRYTFSDLAHPEDIGTLLRTSAEGGRTEVRLSTNEGAYLWVSLRN
SVVADATDGPRLLLTHVEDITERKRHEMQLAHRASHDALTGLPNSAELRARLSARLCTRP
HAGRPSAVDTLDAAYGGPAPGMFPGAADKGDAYDQDAHDFGLDLGLGPGGARQSAGPTGA
GFGVAPYEHHVHTVAPDEDGDQESESAKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVA
RRLTNGVRDGDTVARLGGDEFVVLADGLCQADAQDLAVRLRNAIIPPIRVDGRAVRVGAS
FGIGWAHCGMSVEEVLQSADQRMYIEKRSRSKQQRRAG
>A0A1E3WHK3|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTLYKQLVAGMIAVFILLMVSVFLIEFNTTRNNLEQQQRSEVNNTINTVGLALAPYLQEK
DPVAVESVINALFDGSSYSVVRLIFLDSGEEIVRTYPVQPSNVPDWFIKLGLFDKIHDSR
VVTSGWMQLAEVEIVSHPGDAYAQLWKAFEELVIVFCIVLLIGLLAISFILQRALKPLRM
IVEKMEQVARNHFGEPLPRPATVDLISVVDGINSMSAQLELSFKAQAKEAQQLRQRAYID
PVSNLGNRAYYMSQLNSWLGEGGYGGVALLEARFIKELYDEKGYEVGDNMVRELAEHLKV
SLTTNGIVIARISSDEFGFIIPNIDDDELKLLAQSIVTYVQNLNADPTGMAQAKASLGVV
HNTTSCSASEILTMLDNSLAQASSNPELSFGYTTSDDSRTLMGKQQWKLLVEEAISNDWF
SFRMQPANSSSGQTYHYEVFSAIEHDDKRYSAPQYLFALEQLNVSHILDQYVISAMLDKI
RHDNLTSPVAINIAQGSISQPSFIRWVSQKLNKNKDIAQLIHFEIPEDCFVISPHHCALF
CNAVRSAGADFGVDNYGRNFQSLDYINEFRPAYVKLDYLYTHHLEDEKQKFTLTSISRTA
NNLGIKTIASRVETQTQLDFLSEHFIEVFQGFIVDK
>A0A5I5DU20|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Miami|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3WF11|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MLSKLHDLTHAQETLDLLLQRDKLSRNNHEKSLALTKKQRYLAYASWFGVVAILLMVFMS
IRTYLIKCENKILVTHSGVDQLTGLFNRHHYYLQLSKGKEISLHDEYYLALLDVDYFKSI
NDTYGHMVGDEVLIRLAEAVKLKLHTKELFVRWGGEEFLLLIKADKNAIQRLDNIRETIA
NSPLQTSHGLVKVTISIGVSRKAEPGQFLADESYFFEADQSLYRAKNSGRNRVVAS
>A0A7Y7SRH3|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. B9002|TrEMBL
MTLEILTSQERPQRTWLNALLIGGLTFLLTLFCLELIVVSGRISPLWYSTALMTVIVFRA
HSKHVPLLLLACVLGTALANLIIIGPALSNIKFAILNMVQAILGGVMLRALLDRRAPLNS
LLDWVRFALCAGLIAPLLGGVVALWMLHVGSNASLPFFSTWVISEVIGVLAFGPVLLLWP
NKPLRQILTPGRQLETCLTLLGTLLASYLSLRFLPWPFTFIVVILFWCSVRLPKFEAFLL
FFLNASFISILLAFNWVNLAQNGMLLGQVSTWLPFLLVLLPSHVMALVMDAFQREKHHIS
ESETRFRNAMEYSAIGMALVSPNGGWQQVNQSLCQTLGFPADELKKLTFQQITHPDDLNS
DLQQLERLVAGEIMTYTMEKRYFRKDGEIVWARLTVSMVRDAAQQPHYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYELFGLSPHQTPTYDLWVHL
LDPAERETAALVVQQAIERRSAFQLEYRINLPEGPRYVRSEANRILSQDGQIERMLGICQ
DITPLRALNEALFQEKERMAITLDSIGEAVISTDDEMRVTFMNPVAETLSGWPQEKAAGV
AITELLNITRGASGPRVDNLLLCQLPGEKISPDLDEELVLHTPDGTRVEIHYSITPLKTL
TGASIGAVMVIQDVSESRKVMKRLSYSASHDMLTRLPNRHSFEQRLKQLVNDAANNNTQH
VLVFIDLDKFKAVNDTAGHAAGDALLRELAELMPHHLRSSDMLARLGGDEFGVLLPNCEV
DQVREVVQRIVTAVSEYRFMWLDQPYHVGASAGITQIDQRNCISNVVMSQADVACYSAKH
AGRGQYHVYQEVQM
>A0A8F5F141|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MASHFLNSFLPTEEGWLIGEGLADPRWRIRRWDGEFVDRGAEDDYLGHAQKFMARQLLMV
LWTWLAMVALFAVLDYAALGWSSSFAVLLLVRLAGAVCFLALAAAVRRRPMIAARGRAIS
ILLALSVAAYLLVIAMRPQISLWVYGMTPLLLFMLFSFVPNRLRYSLALAITLAVCMLPM
VGWIHGWAAREQGILALLLAWPIALGYYTMRRVQRLQRMQFALRETLRRQAAIDPLTGLY
NRREFHHRAAQEVARARREGSNLSMLMFDLDHFKRINDRYGHAAGDAVLQAVADLARSVF
RYCDVVCRVGGEEFIVLLPASNLDAAARAAERFLQRLRASDIVFGGQRLPVRATLGAATL
GTRSLDGLMRLADSALYAGKQAGRDRAMLVDADGAVRPLPEGGPGDQVMAA
>A0A8B6I415|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLKKLLLLIIVITSIFTSYIFSFSINAIANDNRTIRIAYPIQKGLTEIDEQGNYYGYTY
EYLLEIAQYTGWNYEFVQVPGDINESITKLMKMLENGEIDIMGGTLYNESLQKIYNYAGN
SYGVANTVLQALYENTDIDNIMSSQGVKKIRIAVIENSDTRLKELDEYCKMNLMSPELVY
CKTNEEQLEALKNGKADVLLNVSMNPIEDVRTVAKFSSRPFYFITPKGSTDLTQRLNSAI
NNIEQKDPYFSTTLYEKYFTPENNQMFLSDEETNYIKDTEKLKVGVLLNKPPFQNIDKNT
GELKGISIDLLNHICDLTGLEFELVPIKSQKDLEKMTKNHEIEIVAGIIYDYEYSRKHNI
IMSRPFVSTQYAMMINNKLNENSLDGKCLALTRGLNYEGQFKENIVWYDTLEECIEAVNK
GDVDYTYGEGYSMQYYMNQPKYKNVRLVPQTYEAQSICFGIIKKDKQELLNIFNKAITSI
SSEKMQSIVYQNTTYRQDFSLLYIMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEK
ISLELKKHTQLYEMTSEYFFEYDYKQDKLIISMPEKGIETYYGLDKNDRESENNNNIANE
IDKIRREYNKKFFDVIKSQENGTTEMYSIVFDDTFHWIRITSKIIYNDRKIPMYVIGKIS
NIDYEKEEKNRLLDKVQRDSLTNIYNAAYIRKLTAQNLLNLSTEKNGALLIIDIDYFKSI
NDTYGHLVGDKILIDVAKVLDESFTKDDIVGRLGGDEFSVYINDIINNEELINKCNDVYN
RIHLIKLPNGKSLSISMGVVIAKCGQEYDELYQIADNALYDSKREGRNRFKIV
>A0A069AJ53|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MQVSILTAIIVIISSSCVYFFNYTLTYKSMIYSLSERSKHIYEYVERNIDKNTFTEINSK
EDQSKKSYKSSKILLESVKNTTGVMYLYTAKKTKDGSLVYVVDGLNSSRSDFRNAGDLIE
KEIWGDLNKALDNHILLPKKIKSTSWGYIFISYFPIHNDVGKVVGVIGIEFEAKHQYNTF
KFISIVTPIIALLTCLISALIAVILFKRISNPTYTDFANTDYLTGLKNRNAFEIDMNNLN
NSNLKNLISIISIDLDGLKKINDKFGHQTGDLYIKQASKIIQYVINKKYIVYRIGGDEYI
IILKNLSHKEINNIINNINLKIVEENSTNELKLSMSIGYAIFDEKVDVSLFDTYRRADSQ
MYDNKRKINKQYQ
>A0A7W3KQY8|diguanylate cyclase|EC 2.7.7.65|Aminobacter ciceronei|TrEMBL
MTARILVVDDIPANVKLLEVRLLAEYFEVLTAFNGPDAIAACEDGKVDVVLLDVMMPGMD
GFEVCRRLKADPATAHIPVVMVTALDHVTDRVRGLDVGADDFLTKPVNDLQLITRVKSLV
RLKVLTDELRLRASTTHSIGMDELLARSDLVRGELPKVLLIDEQTSSAAHICALLDGAAD
VQLAADPQSGLFNAAEGAYECIIVSSGFSAFDPLRLCSQLRSLDRTRSLPIVLLVNKEED
DLTVRGLELGINDYLVRPLDRQELIARLRTQVRRKRYNDELRQSVSQTIEMAVTDGLTGL
HNRRYLDSHLPRLVERAAARRRPLSLMITDLDRFKRINDTFGHDGGDEVLREFARRVKKS
VRGIDLACRFGGEEFVIVMPDTEGALAEIVAERIRSEIARTPFKVGGTEQGVSVTVSVGV
SALVMEGDTVAGLMKRADLALYDAKTRGRNRVVARAA
>H0J1T3|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. GFAJ-1|TrEMBL
MRYKDKNQLATEWRTLLESTPMALRQAVEALIEQHCAHFADHFYSVMLEDPHASLFLSND
QVHQRLNPSMQRWLSAMFAVELADFDALVVHQEKIGQVHARIDIPVNLVLNGARQLKQAI
YQQMKATFDSPLSPGDASVYVSNHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLDWENTLMFAVAAQQEIANFPRLANSEFGLWYFHKACHAFEGAPEITTIS
RHIQQVDSEWLKALASEDTTARLRALSDIRTAARTIIMLLDDVLERASGLEAGRDSLTRL
LNRKFLSVVLNREVEIARHSDKRFALLMVDIDHFKSINDTHGHDAGDSVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRQAVAKEPMLATADTLLNVTVSVGLT
LHDGHPDYQRSMQRADQALYQAKRGGRNRVIVQ
>A0A1V4SQ02|diguanylate cyclase|EC 2.7.7.65|Ruminiclostridium hungatei|TrEMBL
MKEDEFSQILSCMGILRNMYEYARFIDPLRSRIIKMEALDGQAGRLPGFEKSNCFAFWGN
KTTCENCISMRAYVENQSFVKIECAAEKVYMTTAVPLETKSGRIVVEFLKDATGSMTFSD
GTGGDNGEIYSIIDRMNDLAVRDALTGVYNRRYINEKLPLELMGAVVSQQLLSVIMIDAD
HYKRVNDTYGHLAGDTVLITLAETLQECIRRETDWVARYGGEEFFICLPGATLKMTLEIA
ENMRSRIEHKAIPSGNSEIKITASFGVSCRRYARDSKIEDVIAAADEKLYLAKKNGRNRV
EW
>A0A173UYY7|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKEGADGILLAPANSNSLVDSCEKVRKKKIPVALIDSSINSTEFDVCYMTDNIDAGEMAA
KEMLTMLHDAGNSPQEPLAVGILLSSDASQAMVNRVSGFLDYWAKYAPTKWEITKDIALN
GGDVKKAESDAAKLLKKNENIKGIYGCNNTSTVGIAKTLTKQKRTDIVMVGFDMAEETKQ
FIKDPDYRGVSLMQKQDQMGYLGIGTLNSLINGKKSEQKYFDTGVIMIDSDYLMEKKEKK
RYIGLSSTDALTGILNRRAFQVELEEQIRKKEPGFFIFIDVDNFKSYNDTYGHNNGDLCL
KHFAKAIQECFPEGSILGRYGGDEFVVYLKDVTKESVYIYMEKFQKMIANLTLATGEQVH
LSASAGGAAFPEQGEDFISLCRSADVALYNVKQNGKAAFKIK
>A0A5I0EVM9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kenya|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1N6BFN7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. bolletii|TrEMBL
MQHRALIIATVGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
LGPHGLWPRLIHGVLVASALAVGMCWIVLPWPRRRVAIAFVWWADISMVVGACTLSAPAS
RLGALAHMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLMGWNVRLGEATWFDQYVYSAPA
LSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPLTGLLNRRGVQVALGSLLSGQRATRIV
AVVLVDVDELKELNDRLGHDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFDHA
DEAAGLIERIGARRFGIGPHRASVSIGSAVRSTSVAGFDFESLRRAADEELRGAKIERRN
GFRAVP
>A0A151B4Q1|diguanylate cyclase|EC 2.7.7.65|Clostridium tepidiprofundi DSM 19306|TrEMBL
MKIINNRYRIIRKLSHSKVKSSFLVSDVLKNSKRVKIDILNSEYIPEKLINFYVESFIKL
SNIISSNIIRVYDFGLVKFIDSKALEKKQYFYTSEYFEKSEKLIDVVNIEDNENILEFFV
QICYAINYLHLRGMFYNSINTDNILIIKDNGTKRVMLKDMASIELEKYFYSQGKGNIKYS
SKSSILYNNMASNSTDMYLLGESMFYLLCKKNNRFEETYAYDELIEKIDEFALYHCDNEF
DLNILKIIRNMVKEPSDRQFENIGQVIEEINKTFNKQYKYYKRNEIERLTFNFELIGREY
EKSEVIKTYDMIKNGAISSSFIFIHGEMGIGKTKLLKNIEYTLRLDGANIYSSYGLNMVN
KGTNKAFIEILKKIIIESNNINLSKYDSELIKFIPELSKRRNVIPSKPLDGNKEKLRLIN
RSSGFVNEVICNRKVVFIIDNFHLADEFTIDFFKYLLFHDLGNFLFVVSYCDGECLLNKE
FIRFMNEIFQKSNSKRILLEGLNIGQTSKMIQNILNMPKEPMKFTESIYAKTRGNPLFVK
EIIKNLFTKKIIYIDKKTGQWFTDYKNEELPIPINIEQAVLVQIKETDEFSYKILSIISI
FNKPVSINIIKEFIDADKEKIEKTVECLMTKGVLCKHIEDKGFAYDYYNMILKNAIYNKI
CIEDRNKNHKLAAAILENQYKDGREEYLQELIYHLERSYQKQKIIDYCVKNSQKMLKFKN
TSDALKNLEKALSMYDKESVEQNKIDIVYLIANIYFENSEYDLAMTYFRNLIDISINVGN
KIYQIYAMNKIAKIYMDRNKFDIMKDIIKEVEKLLRNVKCIEGYIEWSYLQAYVYLINQE
YKKGEELCEKSLKLCGNKCYELKGRLYNILGNIYLQNSETDKAIMCFKASIINFEVVKQI
KGVIIASNNIGVIYGDFYQNFDEALKYYYKILKICIDNNFILWETKVKTNIASIYFNKTN
YKMVIEYLENVIDVCEKNNFKGYLFNAYVVIANTYLRINKFDKAFKYYQISSDEMDEQID
KIRFSGEYRIMEAELHLKFGDIKIAKESIGKALNIYKYEKSILKTKAELLLFIINILDGQ
ENIDDNIIVEFKDILGRYSNIENRLEIIYEVCIHLYKNKKNDLLYKIFNYAEKLDCDIKQ
KCIKAKRLFLKSLFEKNELKKLELLINALDMSKDDKCICWNIYVDMGDYYFRRSRYYYAL
IYYFEACHVAKSLLLSIPENYRVNFAKFKCISEPFNKFINAKNYINNCSYLDVCNKGITS
LGDINELFSFVDYNDVINDEKIICFARKLYNLSFYDDVRDINDVLIYLNNNDVSNINMIN
KYMAYMTLASTSLIILDENDEFNVIASTSANTVLDKDKLKIINKVKDTSNVLMVSKFYNS
LYEVGILPKDMSAVMCLPIIINDVYDDCFEDNRRKNMFDREIIQGYIYMESNRSLNNFTY
TTLKECLIVSKLVGVILDKIKIKTDASIDKLTGTLTRKYLELNIKEVLEKANNYGGKFSM
IMFDLDDFKSINDNFGHQTGDFVLSKICEIVKKSIRKSDILGRYGGEEFIVILPNTDIDD
AEIVAEKLRSNVHNSRLLGDKREITISMGLVNYPRHAQWGNELIEKVDQALYVAKENGKN
QYRVWSDEFKDTIKRSNKLSGIITGNSVQDQRNVLTMIELVNLIDEELSKDEKIFKFLGR
IIETTEAEKGMLAIVKNGRIEKKYCREIFKSKYVENINYNENIINFVISKKEGTYLIDWD
NITKYNNITGVPDWNSVICVPITQNKTVLGVVYLCVSTAQKEFNFGDFNFVNILSELAIP
II
>A0A1R4FYI1|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta 3F5N|TrEMBL
MPNPTPAVAASSRVPEPSLDPQSLERLRALLSANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRGWLIALFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDPAAFDLLRLADQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRAGLMEWSQKTLFRILGSGGVDGASALGASPFGLWIRHRADFLFDGSPHLSRLNAAMD
RIDRELLPRFTPDAAPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANTNHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALATKAITTGGLSPFHITASIGVAAHQ
GHPDENYLVKAADDALYRAKQNGRNRVEQDRRGA
>A0A1D8JW12|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. LTGPAF-6F|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHESQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A7C8HWU0|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MKENVFNREAKVIRKARSLLSGDVFQQEDGKQSYRDLLMEYEKLVRQSKRLLKMGDRMQH
ALSSLNEELQLREQTYRGIFENATEGIYRTDAQGTLLEVNTALANMLGYKSAEEYLVSAD
EIGTAFNNHHVLGQYNEMLNSKQVVKGMQAKLRCAEGDTVWAEINAGVIESQSAEGKQVA
GVVGVIADITERKRMMREMCRLARTDCLTSLWNRGYFVELATQEIVRCKRFDNDLSILLV
DVDYFKRVNDRFGHDVGDKVLVGVADTLRETLREVDVIARFGGEEFVVMLPDTGLQAAQQ
AARRVRNAMREQVFAYDQKHPIKVTVSIGVTAYQDSSTSLDLLLKRADTAMYSAKHKGRD
RVEYCPLDSVG
>A0A8B4U3C2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAVFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAIFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPVITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSDELMD
KMTSGEGQLYDTKSDTWYYYYSFTNPDWFVIFRVDNTTLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A8B4TNQ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVVLAQLVLWDKRRADS
MPGPINALNLFCFCLFAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGISEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSTQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISMGLETREVGHARITELFNQLLMAADEEMVKAKQNGRNRICMPALTESAP
>A0A7H4N891|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MMGDQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTSSSAENALQAAERIRQRVYDLKI
PHMFNESVATNVTISIGMTPLMGCGYRQRAETGGQRALRSQKYGT
>A0A162TGF1|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MNRLFINLFPIIASVVILFLHILGYAATLYLSNYLVFLIWLLSACIHIILILKLGKVTRF
FHKSMYIDTLTQLNNRNFFNMNITNAMESLQKKQTYVSLLIIDLDNFKDINDTYGHIAGD
EILKQLSHILKNNIRTTDIAARWGGDEFVITLHGVNGKDAFNVADRIRRIIHNHYFYYNG
TSFKVTASIGIASIGDKMDINTFIDLADKALYKAKINKNSVAFLDVCFDL
>A0A6S6WRM0|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MDYQPFVSLWYPPAALSLAAFILVGGRAFLPIVMAATLAGLWMYLELDTHTAFHQQTRHS
LLLAFAHTISYGLGGLYFRKTIHKWDIQQLPQRILYFLIITLFTTFLAASSGIIAFIIIG
EMSWAQAEASWLNWWVGDLAGAMVLTPFFILLLSRLWNSDISWLKPKRRRQNDETKRLWS
SKMLLNVAIVMVVILADHYFNHASIAYFIFFISIPQMWIVYTERMEYTVISLALMSTMIA
AWFGFYGVSEHALTYQFAMCVIAANAYFGLAVPSLLSQNKKLHHQTQIDTLTHIASRNHF
FEVANNEIKQLKEQNKPLSLALFDLDEFKSINDTYGHLIGDQALIMAAQSISTHIRDRDL
IARFGGDEFLLLLPGQTKERAHLTADRLRQKLPAIPTPEGHIPIRASFGVVEINVNESLT
QALQRADQALLNAKRKGRDQVVSS
>A0A2K8KVJ3|diguanylate cyclase|EC 2.7.7.65|Mariprofundus aestuarium|TrEMBL
MTYSNIEKTGADRTFAPHSIMVLLVDDQPMIAETIRRMLDGEDDIDFHYCLDAEEALNMV
AAIHPTLILQDLIMPQVDGLDLVSQYRSHPECKEIPIVVLSAREDPNVKAEAFARGANDY
VVKLPDRVELLARIRYHSQWYIHKRQRDEAYRSLQESQRQMESMNLKLMHLSTHDSLTNI
PNRYHFDQMFSGEWSRSGRDKTPVSIIMIDIDEFKKYNDALGHPAGDKCLAAVANVLSNI
LKRPADLVARYGGEEFVVLLPGTGAEGAKSIAEKMASEVEALRVPHPGSSVSDHITISLG
VATSVADKSGRPDRLLHDADEALYVAKKGGRNQIRMAK
>A0A127MK52|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MSRDDNQRWKEKYLANIDQQERLERRWEVRVDLLRRGLVRSSLAAEGSDKAVDQCMQELR
ELLRRNDIDAGLARLIPRLEKTVLDSEQRRQQRIRQNITALQQIAQQLLNLDLPRDVRLP
LKLFARDLEARASQSRELPVLLGELGNLQRRVLEQLSDAEAPRPGLLQRLFGGREDGEDG
PAQPAPASNGAPASEAPAAPARAEAAVVAEADVAVADEEPLVIPQQAAAVAVQADPEPLP
SPAPSAALLDSLPLPADLIPSAPRPVLLDGEGEQHYALPPMPEPGYSAVAPHIEASLLNL
LDQLQLPATYRPQAQALRERINGSLNWYELVPVLDDLAVLVLALNDSGQAAFEGYLHQLN
DRLSTFLDSLGAVQQGQDAVSDSARRLDDELRDQVSGLQNSVQQATDLDSLRRSVDERLE
GLLGSIERHRQEREAREREAGERLQALVARVSSMEEEARSFQASIEDQRQKALTDPLTGL
PNRAALSERLELEVARVQRFGGELLLAVLDVDHFKRINDDYGHLAGDKVLKIIAGELAKR
LRKTDFIARFGGEEFVVLLPSTPLDGGQQLLEALRTSVERIPFHFKGEPLVITCSAGLTQ
FRAGERNEAAFERADQALYRAKRGGRNRLEMG
>H6LKS8|diguanylate cyclase|EC 2.7.7.65|Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)|TrEMBL
MITKCISIYLFIGVMLFSFIFVNSFVRSKSSYARALGALSLTLQVYLLGYLMEINSGSVS
EMYFWNQVQYFGLPFFSPLWLIIAMLYTGRGKYLKGFGSVIVFAIPVMTFVFRLTNNWHH
LYYSNFQIQHVMGIDIMLLTKGPWYYVQTLYIMFALLLCTWFYFQHYRKSVGDEKTLFRL
LLLISIIPYLSLVLIVLNIGGVGIDYTALILPPCVLLFNLALTRYNFLDIKVLARERVFE
ESVEGLILVNRMYCVVDFNAASVAFFSWFNAQIEEEQLEILIKNHPDLLKSIKDAVAQVF
CFIVAGEERYVSVQVREVNNKKVLVGHLIKFEDVTEREKLKQRLIKTANTDELTGLNNRR
KFGECGKEAFLRARRYHENLSVLMMDIDYFKKVNDSFGHQGGDVVLRGFADLLAVVFRKT
DIVGRVGGEEFAVIMLNTDVRSACEKAEIFRKTVAEKKLTFVEKPIMITVSIGVAELTEE
MSDFEVLMNRADDALYAAKRSGRNRVVGASLG
>A0A8F8CH67|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MRIATITNWAYGATVCLTIVSGVVMLMASNADNVERQAVEQRQVFDQLTEEVDVEIWSLS
DLARLYVIKQDPDLLAEYQQKEQSLKAVEHRLAKLKDNGATDDELALLHEGFRVVDELQD
EQQTALAQVARGEQSQALALLYGKPYEQELERAQDQIDHFRLMLDRRAQDAVQQATNTSR
LLRSLSEVMVGVTALLFLFVLGFILKRRVLRPVVRLSDVVNRLASQDYAVETPNFNQIDE
IGDMAQAIRIFRENGLVRQRLEKERDADWAIRELLARMTQRLQGCENFEDVINVAQLFAP
NIAPGIAGRLYIFDRDPWQMRCVAQWLSPEGKQDPFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPDTCANHSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALYDPLTGLRNRHHLEDTLRTQMSQATRNAEPVSCLMIDIDHFKNINDRFGHEA
GDQVIKNVAAIVQRAVHDHGVAFRYGGEEFLVLLTGVDEEAAHACATEIFNGVHTLSMRY
GLSEIGPVDVSIGIASYPEHVQSDNLLRAADVALYRAKELGRSRIVSFGMLEPG
>A0A4P6Q3X0|diguanylate cyclase|EC 2.7.7.65|Streptomonospora litoralis|TrEMBL
MSRVRAGEIQVAVAEEGAVNRKRLWRRPPDSSTLLAQPRGLIALIAAVVGGAVLFGVCAV
ACTPIRGAEVATFGALVVCAGLCVEAMRRLGKPSGLTRDLLGAWWLPAILLLPPLYSLLM
PVPVYLLLQYRIRRAVVHRRVFNAASVAVSGFAASLLFHSVVAGGWSAGVSLPLEVTEDA
VSTVDGALVALACCVVFTVLNNLSVAAAMVLSATGAPWRKLLADREALMVDGVELCAGIT
AAIVTGLSPLLLAVALPPVLLLQRSLLFEQLQKAARTDPKTGLLNAGTWEAEAGAELARV
RGAGQTAAVLIIDIDHFKSVNDTYGHLFGDHVLLGVATTITGQLRRRDVVGRFGGEEFVV
LLPGADMAEACRIAERLRLRVGRMEINADGEEVGITVSLGLAVLRVHSDDLIGLLAAADL
ALYRAKGAGRDRVCLPVVPRPAIPAQLAVVDDDPRSADAHPATSVAASDAAESDR
>A0A1T5HYC9|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MSIIINSILKKTLIHLKLFTLFFMICSSAYFIYNICNIEKLQNMYITTLNNVYSVARRFG
SFYNNTSTVALNKGTYIFNGVSVIVNTPTNAKILSTGINQLRSNINQLTNNNIWTVAVFE
TASDYSHFDPLRPAYLKGYDKIAINTIVKNEDLMDTYRSFYGCNIKLTDIYKEPGTNKII
RTIYYPIYNNKKLDSLLAIDINNSAFKNTLAKFNNNKITIISMDNNNIYHTSELLPCSTV
DPINLGINFYTLLKATFLPSLLLMFLYHSLTQLIANKNFILRYDQMTHFYRRDYYESKLI
NQKNFNLLIIDIDHFKNVNDTYGHEVGDDVIRAVTKRINNCIRKKDIAIRWGGEEFILSF
PDMNKEQLTIKAKNICDSISRCPILDINITISIGGTSTTNMHFNDAYKVADQALYHSKNN
GRNQATIV
>A0A2X1GC82|diguanylate cyclase|EC 2.7.7.65|Burkholderia cepacia|TrEMBL
MIRLGLTSKLSVLFACIGVIASGTTGYYAYRANRAMLVQEAQHSLLMSTQLLGQRFTTAL
SDVADDALVLAQMPSCALVSGGDNRDGAARARLEQVFYSFMRNHPEYLQVRLIARGDFGL
ERIRVDRDAHGIVVLPDSAFQEKGQFSYVFDTLATAPGHIYLSPIVINHETGTHAAEGLP
ILRVGTPVVDGSGQTVGALVVDVELSRVFDRLERDLPEDYAVYLANEWGDFLVHPDPSQT
FGFDRGRRVLMQDRFAVTRALFDSARTNVTLNGLTDPADAPGQMFAFARTPFGHDEGNRF
VVLGMGRPLADVLVPAGVLGERIIRMVLVSSLMAVILAILFARAITRPLQTLARAATHVF
DDPATEQLPVGRADEIGVLARCFDSMRVEIRTQVAMLRAKQRELTHLAGHDALTALPNRL
LFMEQLDAAIRRAAAMHEGLAVMFVDLDRFKQINDQHGHSAGDRALVAVAKRLSLVLRGG
DMVARLGGDEFIVLIADVRSPAVIGDVASRIQLVMAEELEFGDRRMAVGASIGVSEFPAD
GASAEELLVKADAAMYAAKASAQCAYVRYQELVGSGRAAGGGADEAAGRVASGGSR
>A0A259U8D5|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MSDSTQIVVDFANLSDITLTIINLSRVAFVIANIWLFYSFLTVKNRPIWFQIIAFASTWA
TINCLRDFIMPIAPNHYWVGYILSLLLLIPLSLVFKETLHAKLFVFFMVSSFSQANFSIF
CSLEILVFGNMVGWLLLAGLLLELACIPLIRIYIRPHIKNILDVLDQQHRVFSFFPMLSF
ALVAFYAGQTTYSLFTCIPLVLFTLMMGFSYYLIAVSIDQTKCNQQLELASRTDSLTSLY
NRRHMETRIQEEHERYQRTGVEFALISIDVDLFKVINDRYGHACGDFLLKSVSEDIRKSV
RQSDTVARWGGDEFLLLLPGTNSKIAMELAEHISKTVGKHRYVYENNTLSVTLTIGVAVI
KSGDTADGIIKNADTGMYQGKRVGRNRVVFFDNLDAGVTLEYLN
>A0A543Q2I5|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MKYPEKPDELDAQTIQEILNSFPALELLQQHPIPHALTHNRKLLFANNSAVKLFDGDNSD
YFLGKDITSFIHPLDHGRILNRLEILNDEKTKNNPTEARVYTLNGKIKHIISVSSLIEIA
GHTLVLAAATELSEEMGHEISQSEQNFQRLFENMLDVFYRTDSEQNLTLVGPAALGVLGY
LPEEVIGLPASSFYFDPQARANIVTAVKKHGKVQNFPARLKHKDGHIVDVEITSSAIYSE
DKQFLGMEGLFRDVSEQVVIKEKLHRLATIDELTGILNRRAFLEKANHLIKHLRRQPEYS
LLAVIDLDKFKPINDRYGHLSGDRVLKVFVSLFKETLRETDVFGRLGGDEFAIIFRKCTM
TEGLEILERIQEKMQKISIRLSDNEVSISASIGLTELHEEDLPFSLALARADRALYQAKQ
NGGAHVAMLLS
>A0A554WMM0|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MTTTTTAAIAWALVALVLLALAAAWVAARRARRAERAQRELAAQHAALLHELDALRRAMA
AARVGVWQADADGTLRHADETARSLWQRADLGDGKPWPRLSELRAPEHRAGLAERLREVV
QRHRPLVRLPNLIVRGGGDRLWVSTTAVPLLDEHGTVRGLLGCDVDIDTRQRLLLALQAA
ERRYRLLAEHTQSIIYTIDAAGHLTYVSPSWTALLGHPVEEVIGRDFRPFVHPEDVPLCE
DFLARTLRERRVLPPLTYRVRHRDGRVRYHRSVLAPVLDDDGRLQAVVGNAIDISTDVEL
RAELERVATHDALTGAANRRLFLELLQREIERARRHAAPLGLLMLDLDHFKAINDTHGHA
AGDAVLRGFVQRCGAALRPSDVLGRLGGEEFAAMLPGAEPAQIGAIAERLRAGVAQQPFA
LPGGATLVATVSVGAVAARPDEDADALLMRADRALYEAKRSGRDRVVLDGVAATPAGGGG
ARAALPPFPPLARL
>A0A8G0XYD7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MYTRRRPISDVCMLAPPTSEDVPTASRSLAQSAEGRAGDGVLQGDDIETLRKRERLLALA
IAGSGTGIWDRNVVTGEIQYSSGWKAMLGYADWEVSNRIEDSYQRLHPDDLDRVKATMQA
HFEGRSDSYEVEHRIRCRDGSYKWICSRGRVVDRDASGRALRMVGTSTDITSQRAMSERL
LEAVSLITNLTNEVPGLVFQYRSVPGGPSFFPYASAGITEIYELTPAQVAADASCIDALI
HPADLAAYRASFDASAAQLSPWHLEYRVQLPMQGLRWRQGDARPQRLPDGSILWHGFITD
VTERKRIEAELQELATIDSLTGLPNRRHFMAQIETRLASLQSGRGAATALMMCDLDHFKS
INDRWGHGVGDRVLRHFGSILRAHLRPGDMAGRLGGEEFGILLDGADMRGAVGVARQIQQ
RIAEYPLIEHEQRIDLTVSIGIALMTAADANAEAPLSRSDLALYRAKKSGRNRIES
>A0A1V5JU30|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin510|TrEMBL
MKAIAIAPASLAPAVAEAIASRMDLHLFHSINEALAYIYTEPSDMIFIDGACLDSIGVRF
VHEFKSNAIYRHLPVVAVFEPEALADIDWSELPIDDFVLNSSDAHLIASRLDFIALRSLR
EKDTNPLTRLPGNESIMRYIQKLFDEGREAAIAWVDLDHFKPFNDRYGFSRGDEVLLATA
RIIANAVKELKQEPSFVGHIGGDDFIFVVPVQAAKRLCEEIILRFDMIIKNFYNDEDLSQ
GEIISTDRMGNVKHFDLMSISIAVVMNYEGRYDHYGQVSGDAGEIKTCLKKLPGSNYMID
RRGRK
>A0A6N3CU85|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNTSVAKKASQAVRLLMMVLTAVLIFFFINVMLLVSDIQGTARVVNYAGLVRGTTQRIVK
LEDAGQPQDDLLRAVDSYINGLRYGSDDLNLVRLDDDEYQAKMTELASYFDKLRTEIARV
REVGYENTDIISMSEEFFGICDDATRLAEDYSQEKASALNYLEGLVIIDIVGLVATFAVE
LVRAVRTAALNRELQNKVYLDEATGLPNKNKCEEILGQEHPVSAEAPVALCVFDLNNLHT
VNNSFGHEKGDEYIRSFAQQLGRVASETCFVGRDGGDEFIAVLWDADRAAVESFLARVRA
NVNEHSEAHPDMHISYAVGYALSSDFDEPPTMRELFSQADKNMYIDKNRAKTAEAAGPQR
EER
>A0A1V5JXC9|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin510|TrEMBL
MTLDENWREQADAQETLRPLKLYTESLVGFLSAATLPAAFAGLSGLMAANFPAAVPVIAV
SCGGAGDLVCGAAADALLLGEAERLLGRPATALKSSEAPAAAELGERRDLAVFAQAGEQV
ILSVRNGLEVEVFDEWVKILAPAVAQRLAAEQLKRLAYRDGLTGVFNRRAWQEMLAREAE
LASRYATPLSVIMLDIDWFKRINDGFGHQCGDNVLAGVAGVLGECCRKSDLVFRLGGDEF
ALLLPHTGIQAARTLAERICRCIGGREYGPGLKVSASIGVSEYQTGYEPCQIMRSADQGL
YRAKAGGGNRVEIMKGVQ
>A0A2U3QL87|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MLLLLFISWLFLLADFPVTHPLIWFPLSAVAVLVYAFFIYSAGERELSTEFLLASLIIIS
GIISALKLQWLKLIFFPVVVTIIYFYPVKVIFRLSLLVPVVGMKDSLSGFVSFLLQKTPF
STETLIEEAAFSLALMLSAVVAGVMSERQKKQKDDIERSLGDIREKAKWVTREAGMESLS
NDEMTVHYLASERIANEEIKELLLTIKKAVLADSANFFVPCSKGLELRCTTEDRDYVVTD
NGGVIAACLRERRTFSSGNLTENAIDLGYHKKGKTRITSVIAIPISESSAVIGVLAVDSS
RYQAFSGIEGTEKTVGMFADHLGRILERQRISRALNRELSGLKILERESSSLVASLKIDE
ISEKLCKVAEKISGGQSFFFIIQGRNFELKYHTSAVREGPVIFNLSGTIVNFAVENRHRH
YVPDLRNYASVNVMPFETEGVLSAMAIPLIYENALLGLLVILSREANFLDASRINLLDIF
CNQASTSIANAMLHARIEKMATTDGLTGLFNHRIFQEKLSEQFNRLKRFPEPISLVLADI
DHFKRVNDTYGHPVGDLVLKGVAQVLKETIRDIDIPARYGGEEFAVILPGTSSEGARNIA
ERLRQKVKGAPFSSNGRRIDVSVSIGIATSPSDAKSKEGLIERADKALYHAKRNGRDRCV
VWSGISQ
>A0A380T1A7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MMENSFAFRLKELLEHHKLTLQAVGTALGISRTAVHKWTRGGEIDYDNLRKLADFLKVNW
IWLRYGEEALQNIQQPQVVELPMTDLRRRYTAEIMESETRMKLAQEGARIVTWEWNLISD
EVTYSPNVEQVYGWPVNRNEDFWAHLPPEDIEHMQAMYAQAVADGSGCECDFRITRPDGE
VRWISSRATVVRDSAGRSVKMVGISMDNTERKVAEEELRNSEERFRAIFELAWGALAYID
PDGTWQRVNNSLCELLGYRAEELYGMTFQQITHPDDLAANLQLLQGMLEGQSERYEVEKR
VRHKNGEYLWVRARTSLQRRQDGAPEHLISVFEDISAERCEHERLEAHIAGLEARLTEKS
>A0A3Q9U785|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. LY|TrEMBL
MDKPLRLKLKKRYFLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLNQRHQEIWRVALPNRRTL
PVFGVSESVVREHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTHYSRAISALWFTRQTQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMKGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMALASACQR
SGLPLAVIQLDLDHFKSINDRYGHQAGDRVLSMVASTLAGTVREGDLLGRVGGEEFCVVL
PNTTLQEAAAIAERLRLRIHGREVFLHNNVTLRVSASLGVSASEEQGEYHFEALQSVADG
RLYLAKQNGRNQVCYRSEA
>A0A1C5WWZ1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MAIYVDMNNLKIINDRYGHEEGDFSIKLISAILSERMKDRGIAGRIGGDEFACLMITEEE
DDGRKLIEDIYRDFHSFNRGSSKVYNITVSAGAVNLPAEQVTSLQEMLTQADEKLYEVKK
YRKKDVVKREYRK
>A0A1C6KLS3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MCTENHDKYFKKIFEFLPCGIFLMKLDDDLTLQYANRYFYHLFGSSQEEEGENRFRQLRL
LVLPEDFVKLFGQIHDFVERRQRSFDVMFRGLYGSGEIFWMTMRCLWLAEKPDSLIGVIS
DAGEHRATNEQLRVSLEETRLAFQLTDKMMYTYYVEDRRLCLPQKAADEFGLPTVIQDVP
YSIVEEDLIAAESRKAYIEFYEDMIKGKPNGQATVRKRRKDGSFGWYSAKYSLICNWEGK
PQRGIIACEDISEQYEKELAYQKWCQYFASQKKNRIGCYEYNLTQNSFDEESSSKPPLSR
YGNSYTETMTYIAEYLVAAEDRTMFNRFFDRERLLQRYREGQCHMRLEYRWISDRGDKLW
ARATIQLLKEQFTSDVKLFIVIHDITGEKKHEEEIRCRLEEDMLTGALNRITFHEKVREV
LRRDDFYGQHALLILDIDHFKGINDSLGHQFGDQVLGDSAAILKRELRKDDLCGRIGGDE
FMVFLNDVPSEKELEPRIAQICKSLTRCYEGYGTVSCSMGITFYPKDGIWFEELYQKADL
ALYEAKHSGRSCYKFYRMPFEQNSQNVC
>A0A1C6LDW7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEKSVKDNPEYKMKRQGMIIGLVCLAVMVFLTIFLMSRYRQRTEKIFTELMEESLLSTHS
EALTEMENFLAGSTGADKVEEAWEALNEDEGNVLHYVCNSDGKILAGDMRIFDIEYTVAT
VLHSQHVKDNSISQVEKSLKKLTYGAPHIFTELEKTDIYLVASKLEGRDCILFSEYRSAK
MKNYKAVLINGNRMIIFTLLGCALIMLLFTVRFYMKQQKKVMKGQARYDILSEFSDTVLF
EYDCLEKTLVFTPNITTLFGLKEIGPIRPFDNDTDFTMVHPDDVAKVKALLSSIGDNSDE
IDDFVIRFKDKNDNYRWVRWMGRLIRGRLGTPQAFLGKISDVQDEMTREQDLREKASVDG
LTGALNRKAAEQKINTLMQDKECKGYLLMLDIDDFKTVNDTMGHAIGDLALITLVKLLKE
HFRREDIVGRLGGDEFIVFMTNTELASAVEAKGAEILDILAKSETTPHFTVSIGAAAYPA
AGNDYESLYLAADNAMYASKKSGKNRIYVDNGQQKKE
>E9TFB6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 117-3|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLYQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A3P6M856|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAATSRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNYKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKIT
>A0A3R0JFT5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRQDAEVIMKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLRNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNEMDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A1S9JXC2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8H9DKQ3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAVDIAMYQEKKHKQKTPFVAHPALHS
>A0A3R0XCD8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFTVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWELPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNISALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A0S4I5Y4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MDTRTGKGLSFAKRIYLPRVLGKGVGLFAVMAAVEPLSPPTWVWAFMLFNGLLWPHLAYQ
WAARSKAPYQAEQRNFFLDSLMGGFWAGAMQFNPLPTVTVLSMVTMNNVAAGGKGLAIRA
GMAQLAGMLAACALLGPGFQPNATAFQVYACLPMLTLYPAALGWVCYRLAIKLAEHKRRL
NTLSLTDSLTGLLNHGAWKDLLARRFSGCRKQRGEAVVALIDIDHFKTINDTFGHVVGDQ
VLRQVSIELRGALREGDKAGRYGGDEFCVILPSTTEAQACQAMERLRERVASYRDPQTPQ
LRISLSIGLCPFDPSLETPDGWLRQADTALYVAKRNGRDRVMVTHRANASVAPSAEPPAF
ISLAR
>A0A380CLJ5|diguanylate cyclase|EC 2.7.7.65|Sporosarcina pasteurii|TrEMBL
MKYRGRFILLFISLVSACVYLVIGNVQIIPFTIFTLIEFSFSWFIGGWYDKYRYLSYHDP
LTGVYNRRYAYMHLERYFKIANRRHERIGILNIDIDNFKLINDTYGHSYGDFILKGLCRI
IVENTRKEDILVRWGGDEFLLFVIDKDDTSLENLTYQINDTIKTDLNNYGESKKHEVTVS
IGHSIYPDDGQNISDLLSISDKRMYKVKSITKEVSLL
>A0A375HVX6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus neocaledonicus|TrEMBL
MVAFSLSVMLLLLLLWRGLQLSQDREIESLRHMQAVRAQSMDALLQREAERLLSVRNVAQ
HLLQIQATAPGALDADLRATLAHRDQPVWPVRAHDAAAVYGVSAAVLRGLDGFARNEARL
AADVIVARSLSHLLSAAPEGSGIRRRIAYVSRNGVLTAYPSIPQQEVVPAVQRLAAAPYF
RDSLPSHNPGRRVQWRIAPATVEREQVSLFLSVPVYAEGDFRGVAMLELPQRSLDDQLSS
APFHQASSYLVDREGRLVGATTRNVRAGETMQAALSGRWPAATLDAVFHADAGLLDGAGG
ASGSELMFRQLRQGGLALVDEIPVNRLWLAGAARLSGVIGAGAAALGILLCATLAVVHSL
FRHYLARGEALRTLAETDALTGLANRRVFAARFAAEQRPIAVVMLDIDHFKSINDRWGHA
SGDVVLRAVADALRGGARKDDLPARLGGEEFAVLLPNTGVGDAAAVAEHLRQRLEALRCE
PAPDAGSSEPIRFTASFGVAGIAPGNGGNLDALLMAADRRLYEAKANGRNQVVAR
>A0A433P3M3|diguanylate cyclase|EC 2.7.7.65|Pectobacterium polaris|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRGHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAYTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A2T3CT23|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. BBP2017|TrEMBL
MLISGKSQLQFMRNIAERLLIEAHIQPAMRRNEAIGAAMRNSQQPLWELPVPKSDAPVRA
LGDARVANIPGLSREPQQLVEDLHLAHAMSQVLPAQFQGEPHLSRILLLTTSGIVIAYPA
VRDEQLEPILRKFTSSPLMHLNRANAEDLDIAFYPPPGSNLGSMPHVLLSTPVYLNAVMR
GALIYDVPQTKLQNYLYQTTAHDEQHALIDDEGSLVASSAQMFTSHQGNWLATLPASNIR
LSVPMLFQRDHGTLKLDHGYLQYRELQGIDLMLTNYISTADLRAAVNAQVNMLVLGVWVL
LGLLMFLTLYIVDRLFKGQLRLNRQLREMGLVDSLTQLANRRRLQSDFGGLLQRLREDQP
LALCMLDIDRFKHINDNWGHSAGDEVIKHLATLCRALVRPQDLVVRYGGEEFCVLMPDTS
LADATRVAEQVRAAIAQSVCVPEPGTLLAGAPSLEIRLTVSIGVAELRVDGCQGLEDLVA
TADRRLYTAKKGGRNQVINSD
>A0A1M5WTY9|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MYILGNIVRKTSPVLTEHHDTQPLKYQFYAIFKMCSIHNPFSMLKPKRPENEQNRLTALR
HLNVLDTPPEERFDRITRLARRLFDVPIALVSLVDENRQWFKSCFGLDAQETSRDISFCG
HTILENQPFIVPDASKDLRFADNPLVTGAPHIRFYAGVPLHYQGCADEICHLGTLCIIDQ
TPKYMSEAELADLIDLARLAERELSASHIASIDELTHIQNRRGFISLAQKASSFCQRENK
PYSLAYIDLNQFKPINDQFGHAEGDKALQMFAQLMQESFRESDVIARMGGDEFVVLMPGI
DEHNAQIAINRFRTLVNQYNQDAGNGYDIIFCEGLISVSPGHHQTIEALLCEADKLMYQN
KNIKSSGTKPE
>A0A1M6C576|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MHIKRILPENNSYTPSIKLHTFRWLLGFAIFCFALIWTIDELSGLISPFDEVSYPFCIFF
FILIYFVSLKRSINREYLFLFTYFIVAGYLTSSSIYHHITLHGTFSNASQWLGLNYVMAY
LFLDVRKAAFTSIVVFIMTMVGHYVVLMAQFNVSDALGVLLNIGVSHLVYMVLLWTVLRM
RIQSAKIQERLEMLEHYALLDPLTQVFNRRGLEDELFQAELAYQQQSQSYAILLVDIDHF
KLINDRHGHLIGDWVLTEFIAVLNKTTSPEDKLGRWGGEEFVILKQDASHQETFDCAERI
RIAVSERIQVVEGEMLSVSIGIGYSGEAEDSRGVLGIADRNLYTAKNTGRNCVMDTASAA
TVKATKIS
>A0A1M5ZLX6|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MSPMQINSPWFRLITPVVVVLAVWVGIEKNFLRLPFHDSVLVNMPYVLFIVSLIIAQIFK
QSRMGMLAISQLLCYGIIQYRLQVPLSIGSAKLELSLLSFLFPVTCMLNYAFRNAAVLTK
NFLLYILILILFFAWAMLIINHTTQGGFDDISAGLLASVPQFSRLPFVIVLYLFAITGIT
AILLLNKNKALDAITYTSILLNANIFIFFHVPYISTLLASVSGIFLILYLISAGQEMAFN
DRLTTLPARRALEFDMRHLGRRFAIAMLDVDHFKKFNDTYGHDTGDDVLKLVASRMLHVK
GRAKAYRYGGEEFTIIFKGKDAEEASKYLDILRQDIQDYKMSIRNSSDRPEDNKQGLLKR
RNSNKKPKPDKTVNVTISIGVSDSHSSKVPDEVLKLADQALYKAKKAGRNRVKIVK
>A0A5C6A8V3|diguanylate cyclase|EC 2.7.7.65|Botrimarina colliarenosi|TrEMBL
MAPVTTTSPEIAARLATVLDSTSVPLAVLDLSTGLLGWRNAAFSRLAQQQGLTEPVLAAE
LTVTGWRRNVQPLPGGEGSAALIEWLPETPRDAAATVPNDLDPVTSVLCRSAIEGALADR
FAVREQRPFALAFLDLVDFKQVNDQYGHLVGDRCLACVGSRLRQAVRTGDLVGRYGGDEF
LLLLDGVHDQATYAPIRDRLLSELYEPLVIEGASIRIGASIGVAYSRADWEGVDAMLEAA
DRAMYADKRGESTPS
>A0A174DXI8|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLE
ITGNQNDELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKEILKSLSREKER
LNSCENQLPIDYACGWALSSDDMACTMQMLLDDADAYMYKNKQLCKKYN
>A0A142CM97|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEVFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRTLKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLGEPVHRFV
>A0A0M7AB13|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MTSRMRLHLVENEQERLDALHALQIVGSERLPEYDAVVEAVAAIFDCPIALISLVDERDQ
WFKAACGVDIEGTSREVSICQHALSADDLFVVPDTLSDERFCDNPLVVGEPNIRFYAGCP
LSLDGKNRLGTLCVIDQRPRKPARQQLHQLRRMGRVVEGLLKSHQANVEKEAALARAEAE
HEEAVGKGRLLEEIAAVSGVGGWELCMNSQKLTWTRKTHEIHDVSDDYVPNVETAIDFYA
PEARGPITRAVARGIEQGRGWDAELPLVTAKGRQIWVRAVGRPIEKDGETIKLVGAFQDV
TERKQVEQAVRESEAAHRTTLETLSEGVLVLTRSGVIQSCNPAGAKLLDSTTERLVGRNV
KDLTVAVVCDLGVTHQEVNTLELAAEDPLLVCDATAELKHSGKAASRWLRVNARPIAQGG
EYALDGVVVSLTDITETKRQANTLQVIFDNFPGGVAHYSDNFQLASYNDEFGNLLGYPTD
MLRQKLHILDYLKFSAERGDYGPGDPEELALEKFRLNSPTKAYSYERHNADGRYLEVRYT
PLPAGGSIFNFFDITERKEMEQTLAESERLARDRLAELEAVLGNMRQGVSVFDKDGKLIL
WNQQYLDIFRKPYGEVREGVSLIDLLRAEKARGDFDGDVEEHYNALYEKLSRGEVVRTKF
THPDGKVIGVVHAPLPDGGWIGTHEDITLREEAAARITHAAHHDDLTGLANRALFTARLQ
EALLDAQMQGTGGHLLLLDLDRFKPVNDTFGHDVGDELLCQVAQRFKECVRATDLVARIG
GDEFAIILQGGGPGEPWVTEIAERLVTALNQPFDVFAHKVSIGISIGISYIGVDATSIES
LQKKADIALYEVKQNGRNGFRFYEAGRAHKVIRGGAA
>A0A0D0TG02|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNSSSRAQDQGDVIEEQVRTDRLHQLFRQSFSAVFGSYLGAAMLCWLCWDRFEHRVMLAW
LVLLAGASLLRLKMFMDWFGCPHSERTPARWERRYWITLMLSAGIWGAGALAVMPSDDRV
SQVLVMLFTVGMSVSAVSCYSAYRYMTLGAMALVLLPCTLWLLFQPSSMQVGVAIAVLVF
STFVVSATRKLSDALEKAFRLTRQMEQAHTISTHAAQTDELTGLKNRRAFFEHAQLLYAQ
CRQNQQPLCALMLDMDHFKYINDTYGHQAGDQVLRQVGGVISASFRQADVSGRLGGEEFA
VLLPNTSLETARTIGEQLIESIAGLNAEPVQGLTASLGVALTQGNEQDLNDLMNDADQAL
YRAKSLGRNQVVVAQ
>A0A173ZQA6|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MDSLELDRSKGSLLPHTVVSAKQNVYFFSPVHFREREIGYLVLESCDYLLDHQFLFETLN
TFRTSIEALYGKLILRKKNKQLSQLYIHDSLTGLYNRMAYEKLALPLFQQYMQKGRPVGI
LFADADHLKYINDNFGHDMGNLAIRSIASVIQQQCPVGSISMRYGGDEFVCVIPDYSQSK
IQQLKESILASLEEFSSTSRTVFPLEASIGFVVADDPVFSLNDYINLADEKMYAEKKERK
ATRQ
>A0A5E7T6S1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MINNHSEAMSQSDTRANVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSK
GQDPELNRHLDRVVRDFDGCPPESATRLFRQYIIRDELEDARAEQQQVISLVDGMERDVS
RSVKGSAHFQHRLGQCLEMLEEPVSDRLPGILNELQQSTRLMQSQQEHFLAQLHSAQNEI
KTLRDKLERAQQAATLDGLTELLNRTAFSRLLEQALGKGSRTVALVMLDIDHFKQFNDQY
GHPLGDRVLQHVGQVLRGALSPSAFAGRYGGEEFCVVLEDCADLDSACAFAEQLRLKVQS
LRIKARGTDTVLDTITASFGVAFVQPGDNPESLLTRADDGLYQAKRNGRNQVFALHKSPA
TTLS
>A0A5E6X1N1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLFKPGSRPTLRSVIGRGHLTVALVGVAMASISLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKAAATEALALIASTEEVADAQVLDPQGKLLARWQRPETGLFSELEMQLAK
TFLEKPISMPIVHQGREIGSVLLIGHGGSLMRFLLSGLIGIVLCTAVSAWVALYLARRQL
RGITGPLRSLAAVAHAARSERSFDRRVPPAAIAELDNLGNDFNALLDELEAWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRSLRNAHKLNERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAILLTPLHKTEDAERIADKILASMEEPIAL
PGTTQVLTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRVARGAQHTAGSEHPVADVQT
RS
>A0A174DC35|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKKKKNISTHYVAAIIIFICAVVISLGVFLLYVQKSIDTNSQKTMTSNVAKQSDHALSIL
NIHYGFLNSIADKMGDSSDILSDENMELLVSLAANTDFERTALIEADGTAYYDNGAIKNV
AQRKYFLEAMKGQATLSDPLDSSIDQETRVILCVPVRCNGRIIGALGGSYNVTALSQMLF
NDIFDDAGYSLIVTKEGEIIAYDGEPSYHKITYGDNFFDFYKDRTLLSKNSLVNVKKDFS
AGHDGLIKIRTDSNKKSDQYIAYTRLGMNDWMICYVIPVSDAQSSYSFIKSYEGIFMSVF
FILVLLLVFYIIHNNRIRNEELRRDAQTDGLTGVLNKRTTEALINEILEQRPHEKGTFII
LDVDKFKEVNDHYGHAVGDIVLSTLGQTLRNYFRENDIIGRIGGDEFVIYMCKTESKERA
VTRILALADTVKNLSFAEMNGHHITISIGISFAPEHGTCYMDLYKNADTALYETKQNGRD
GYFLFQKQDSII
>A0A5E6PAV3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGRGLSLARRLYASRTLGLVLGLLCVGAAMYPLQPAAWVWALLLFNGLLWPHVAYL
WARRARVPFHAEHRNILLDAFLGGFWVAAMHFNPLPTATTLAMMAMNNVAIGGLRFLLVG
TTAQILGLGIGWLLFTPSFVAQTSSLQLYACLPLLVFYPLALGWICFQQTTTLGRHKREL
LALSRTDSLTGLFNHGAWKDQLDVEFQRCKRQHQGAAIALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKHNLRATDIAGRYGGDEFCVILPDLPLSSAAAAMDALRDRFAGLGYEQNPA
LKVSLSIGLAAFNPAHEDAMLWLNDADQALYEAKTTGRNRVICCSDIRPHHELLDPV
>A0A5E6Q822|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLLTPGSRPTLHSVIGRGNLLVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKPAATEALALIASIEEVADAQVFDRQGQLLARWQRPETGWVSDIELHIAK
AFLEEPMSMPILHQGQEVGSIRLTGHGASLMRFLLSGLVGIVLCTAISAWVALFLARRQL
RGITKPLRNLAAVAHAARSERAFDKRVPPADIVELDDFGNDFNALLDELESWQSHLQSEN
ETLAHKASHDSLTGLPNRAFFEGRLMRALRNANKLGERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKTADAERIADKILASMDMPIPL
PGSTQVLTSLSIGVAVYPDHGATPGALLNAADAAMYQAKRLSRGAQYTAGSEHPAADVQD
RS
>A0A5E6QFP5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MINNHSEAMSQSDTRATVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSK
GQEPELNRHLDRVVNDFDYFPPESAAKLFREYIIRDELADARSGQQDAINLVDDMERDVS
RSVKGNQNFQASLGQYLQMLEEPATERLPSILTQLQQSTQLMQSQQEHFLAQLQSAQHEI
KSLRDKLQRAQLAATLDGLTELLNRSTFNRKLEQAMNSAPTGVALVMLDIDHFKQFNDQY
GHPLGDRVLQHVAQVLRDSLPGEAFAARYGGEEFCVVLKDCPDLAAAGAFAERLRLKIQS
LRVKARGTDTVLDTITASFGVAHAQAGDTPESLLTRADDALYQAKRNGRNQVRQQPDVAV
AAI
>A0A806YX95|diguanylate cyclase|EC 2.7.7.65|Obesumbacterium proteus|TrEMBL
MKLLAIEGRFNINQEKGLSDTPATPQCSRRFTPQRIINICFFAVFVFTSLLFWRQGQVLN
NGYQASQLNRLENVSAQLGSRMQFRLDNLLFLRNYMRYMLSQPIMPEQKRLLEAEMATLR
VQDIWQTGHSHSASPPLNGIGDNQMGLLPSSDRPNNDLWLTELNAAMRLKALLPLTNLNQ
ALQPRIYYISRSGFYLSSAPPRDKSLISGLYTHMLARPYFPMATPEANPHRKAFWSRMFD
NQQDGMLISATAPVDYGDRWWGILGMDFSIKRLNYYLQAALPSHPHSVFMLYDSHFEPIT
SSDSNWYRGKYFSEAQRLLLQKAVLKQSEGTIRIGTSFVTFTRMENPNITLISLQSLRQG
LQDQYGRISLTLVALWCLFVITLIGTHYVISRLVRNMETLQNRLSWRAEHDPLTELLNRR
GFFDKAEEITRKGQCYGRSMAIIQVDLDKFKNINDVYGHHVGDLALKHAADTMTSMLRKQ
DIIGRIGGEEFCIMLPNAVLSEAVAIAERIHAQLNRQNLILSDGRTVEVTASMGVSACSG
TTGCSIESLQSQADKRLYLAKTAGRNQVCASDMDA
>A0A1V6IRG5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MLGIFPQDDHNQTLRLKRFFMALGSYLMWFAICVMFYAQGQMTRGNIQVLVISSLGILFC
NVLIYAMIRSGYNKRFKDPSLTLLQMIIATFWVMVIAYYADTTRPLVLLTYLVVFIFGLF
RLSVWQFLFLSAFAVVNYSLVIFLLYNINPDLVSTSDVLSIVVLALVLPWFSLVGGYITR
LRARISHAFSTIEKLAIIDDLTQVFNRRQMFKILEYQKALVDRGIHPFSICIFDLDHFKR
VNDTYGHVAGDFVLKTVAQETQKNLRNIDHIARYGGEEFILILTNVEKSQAILCADRIRN
LVKKIVFENMPDDFKMTISVGVTEYQAGEDIQQAINRADTALYRAKTNGRDRVEYEPMSK
DKGEKG
>A0A1C5YLT2|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKIKKEINLFAGMFTAEEIYRYGDIILLLGHIIYLVLFYRFGVYQMVYYNYFSVAFYAAM
YFLLHFKKIGKMSFTYLVLGEIIVHACMGAYYIGWSAGFTQIMLCIIPIPFFIVQNRKAI
PYILSSFDVVVFIVMRIIVTNRVAPYSFDTNRENILYIYNTLCSFIIIIYVSSIYIFTNE
HNKREAKAQNEKLQKLATIDPLTQLFNRRAMMDFIKKIESNSRRTNSVYSMCLGDIDDFK
HVNDTYGHEVGDKVLRAVSDVIAGNVPSEGYVCRWGGEEILFVVPNTDTESCEKIAKSIC
QKIHECTFKENSRSFNISMTFGVYSVTPNENYDEGISKVDKLLYKGKNQGKNCVVSK
>A0A8D9PI51|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVIARDASKPEITDNHSHGLCQFGQWIEH
LGPLDNDELPYVRLMNSAHQHMHDCGRELMLAIIENRWQEAHFAKFQEGLLSFTATLTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDYQLSNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATSLANWTRDYETVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAH
PGGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFINKQDVISRV
>A0A0Q9YP70|diguanylate cyclase|EC 2.7.7.65|Candidatus Berkiella aquae|TrEMBL
MSQGWVKSYPQNEGSELSKILQTTLDVYDLLKHFHRVLQQHIPYHSFQFNNDQTGHGLSM
GAVQAFEACFELTLQDECLGHLRLTKPSTFTEEEHKIIENALTQLVYPLRNAILYHTVVI
HSVTCSLTQLGNRSLFDQTIQREIDLAIRHKSTFALLLLDIDDFKQINDIHGHLAGDTVL
QQVGKILQNLKRQSDYVFRYGGEEFILILSQSNTDGAILVAERIRQQIAHQEFVFEGKTI
AITASMGLSHFHPEDNFKSLFQRVDKALYQAKEEGKNRIVTD
>A0A2C9EHX9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MPRRSPLYSQRSLVLVLIALLGSGFLATSLLSYYASRDSIRDSIVNTELPLTSDTVYSEI
QKDLVRPVLISSMMARDTFMRDWVVAGERDPSQMTRYLNEVMTHYDAYTAFFVSNTSLTY
YQAKGVLKKVKADEPRDAWYFRVRDMSTPYEINVDPDLANQDKLTFFINYKVYDYQDRFI
GAAGVGLTVDAVIKLIDKYQQRYQRSVYFVDAFGRIVLTGADGGPQGARSGQSLHELGSL
KELLSQLPKPHSGSYEYNSQGQGHFLNVRFIPELNWYLFVDKREDGALNSIRQSLYLNLL
ICLVITAIVLVLLSAVVRRYQRKIEAQATLDSLTRLPNRRGFDLLAAQALQEAWRDLTPL
CAVLLDLDHFKRLNDTYGHLAGDQVLSGFARDLQGCLRQSDIVCRWGGEEFIVLLKDTDS
SVALGIAEKIRLLTEQQRYHYEGQPLQLTVSIGLTSLQAQDTLHSLLSRADHAMYRAKHT
GRNRTCVEMPHSSHE
>A0A8H9NTU5|diguanylate cyclase|EC 2.7.7.65|Citrobacter farmeri|TrEMBL
MNDENFYKTAVDLDEASFSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVATALVASPV
SGVWWLLLVGWAFVWPHLAWQIASRAADPLSREFANLKTDAVLAGMWVGLMGGNALPSTA
LLMIICMNLMGAGGVRLFVAGFALMVVACLVTLQLTGVSLALTSTALEGVLTLPVIVIYP
LLFSWISYQAATKLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHRDATLL
IIDIDHFKRINDTWGHDVGDEAILALTRQLRLTLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRVHEGLHGLRLACAPQVILHISVGVAPLTPQFGHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A1S1VAC4|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MKKIFRHKNSLLFKLTTFGAGIVVMQSTLLMAVLILGGVLEETRLNAYENFNNRVEERKS
YLELEMKNRWTNIDPFINQISLKLSEDYSSDQELLKSVSKDIVDMLRTTQTTGVYLILAD
DMSKESYPALHIRDYDPQTNNYSYSDLYMVVGPSEVAKELKAPLDRTWSYDFMLTDTNRD
FFMKPYQIGFGQSDISYDSKLMGYWSEPFKMSEKDLEVMTYSMPIFDSKNSFRGVIGVEL
TLNYLANMIPSTEIQEKDSLGYMILNREESDRDMEPKVTVGSFQKRLIDKEDGLSLIEKN
EQFGLYEVDSYSGKEDIYASVEEFKLYQPNTPFESEHWYIAGFAKEDNLLSHVQYIQKLL
WFSFGVALALGTVGGAFFSYRASKPILELSEDFRSRKRDEKLKLRATGLFEVDELAKAME
ESNNERIESASRLSRIIDLLDMPIGAFEIKSNSGTVFVTEKLPRILGLDSTDREAFQNKI
KEIMEHPEKDEEDVYRIEGMPRKWVKLNTTETETTVIGVAEDVTEEMEEKLEILKERDID
PLTKLLNRKAFKSYMESILDSTDLKATALVMFDLDNLKSVNDTYGHKWGDYYIVEGVNQL
KNIADRDKMLLGRRSGDEFVLLLHGFDSKLEVRECMDMFYSRLKDLPLKFPDGAIRSLGI
SGGLVWIESWPGNYDELLHRADEALYESKSKRKGSWTEDM
>A0A515CRN3|diguanylate cyclase|EC 2.7.7.65|Serratia liquefaciens|TrEMBL
MDISAPNHLITRQGALLTHSLLAAMAVFLLALLCLTLSNESSHFTPLWFPTAAIIAVLFR
HSPRQWGLPLLACGVGIVAASFTLFGFSWFPVKLTLINLLEAVVCTLLLRRMLLQDDPLN
SLASWLKFVVCAVIFTPLFSALLAAWWVPAPGHPFWHPFSTWFISEAIGVLSLTPIGLVY
RRRMLDTLNLYTLLLTLIVALTFSYLALSYLPFPFTFVILPLLWAAIALPRLEAFVICFC
TTLMITVMISIGLLHFHAPTGPFSDIEIYLPILLILIPAHSMAMVMHAFRVEKQHIVESE
TRFRNALEYSAIGMALVSPQGKWLQVNQALCKLLDYTPEALRRLTFQEITHPDDLNADLT
QLHDLLDGHISSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKRTA
AENHRLMERITLANKVGGIGVWEWMMHGEELTWDKRMFELYDLSPDQTPTFSLWRTLLVP
EDRERTDREMATLLKRPGPFVLEFRLLTREGKVRHIRGQGNVILDAQGLPLRMIGTNIDM
TEVRNLTEALHEEKERLHITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPV
AGVVRMTNGKDGEEVENPIQCCLQENRQLSADYALVLHGRDGRCFDIQQSVSPLKTIDGN
VMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALV
FLDLDRFKAVNDNAGHAAGDALLKDLSLLMRHHLRNSDCLARLGGDEFGLILFDCTREQA
QSLIQQLVNHISQHPFFWEGKIYHVGASAGVTRIDADAGKSSELLAQADIACYTAKHRGR
GQVYLYEARQKMILERQHELLTRQEVTDIINDGQLLLHVRAVAPPKTPLAVCFYQLKLQV
RDQDGQALASDDFISAARLYDLTQEVDRWIIGQILTQRAPDIARKGLSIALPLTTDSLLD
ASFQDDLLAALDASPLQPGALLLAVDDAVVLEHAGICRPFLQQLQQRGCKLIVNGFGHSL
NAFDELHGQKIDYIRVDERFITNVHCNQMDELMVSMLNGATHRVHAQTLAGPAHQQITLN
TLQAIGIDLSDGDAIALEQSLTELLSGGYFGIR
>A0A8A0RLT7|diguanylate cyclase|EC 2.7.7.65|Koleobacter methoxysyntrophicus|TrEMBL
MRMVKNIMNQELFTIDPLAGVSRAAEIMEHFKIGCLPVVEDGKLVGIITSRDIRKTHPNR
LIADAMTRDVITVPPTASIWEANELMEKYGIERLVVVDKKSIMGIVTKAQVIAELNKYID
SLTNLNGVRVFYERACQLVKEGHEITVIFLDMDDFGLINKEYGHIYGDSIICKAAEILNK
IVDKNRDTLCRYAGDEFAIVTTRPLEDAKEFAFQLVNAFTNEKWPEEIKVTVSAGVAGGR
RSGIRNFNENSNYIVKNLINMASLASTKAKKQKRPVVFVEAVDFREIV
>A0A136WFQ1|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MKKHFLLLSNLIIILALMAGFASIVYKETKSYQNLSEEYLENIVGLANTDVSRQIESSMT
KPVMVSKTMANDEFLKQWFSHERENQKNDLYMQQLYSYLSTYKEKYGYTTVFCISDQTGN
YYVQDGLSKVISVNNEHDVWYYNFISSGNEYDLQIDTNEAKGNVITVFINFRMEDGDGKL
LGVIGVGLEVSDLESIIRYYEENYDLSMYIVNVGGSLNSFDNNTDVFVSEEELARRTKVE
GKILTDFSGESKLRWYTAENRRICLITKYDATLGWYLIVERDMNSISSSFRKGIMDNVIF
MLISLAICIIVVTTVFLNFNRRIIEIENIDELTGLPNRKLFSMKYLSFVSKNQGRKKTFF
MFDVDNFKNINDIHGHLFGNAILAMVGERLQNTMNGSGIAARWGGDEFVGILDATLDEAE
DILNQFMDTLRNENKESCYHITVSAGIAEISETLSVEQMIKKVDKAVYCSKKSGKNQITV
WKKEDSQVK
>A0A7W2VC44|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00325|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>D6CRP9|diguanylate cyclase|EC 2.7.7.65|Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)|TrEMBL
MCSVSTRSVIRWLFWSVGLAACYILVAWLVLGVRSSELILWPSAAVAAFGLIARGPSMVP
AIALASWVSDYMLLGWGLQASALIAAGDVLGPLLGLWLLRRRARWQGFETTADGLWFIGA
MGVIGAGVSAAVGAAAAATFGFGQTPVSPDLGVQWWVTDMASIVVLTPAAELLRRVSLQT
LRAAFNGEMVWLPALAVIGTLLVYLMPVGQSALPIGLASLVMLPLLWSAMRLPLAVSAAL
SAVISLLIVTATVLQQGPMYSMLGSDRFMSMQIILLAFASAMLLAGLLANERTVALKQVR
DINATLEKKVNRRTAALQISQATTQAQLRFQESLLNALPNPVAFSDPQGRFTRVNVAFNL
LVGLSGPEIHGRTGTQILGTTLGRIWEDMDSELLSGSLQVTREAPYLHPDHEPTVWILNK
ALVRDAVSRQIVGVVTSMQDITAIKQLQQQLSEDEQRFRFLAEESPVPLVITRTSDAALL
FSNKAADSLFRGSYAEHAGQSMRPLWGDSVDRDQLLARLQREGGIVRGVEAQFRRFDGTE
VWLLLSVTRGRYRDDDALIFAFKDITEAKARESELRNLAYTDTLTGIPNRRYFLARAALE
LRRAQREGSPFVVLALDIDRFKQINDRFGHQVGDAVIRCFAQTCMQQLRGPDLCGRLGGD
EFAILLPQTTRQVAFDVAQRLRLSIQEASCLPSSAPDGLTLTTSIGIAEFLPTSTLMDAD
ELLDRADQALYRAKQAGRNRVEIWTGEAPAPV
>A0A136WDX4|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MIGGRCMRRVILWLFCFAIVVSFLICGVSIQFDVRSTAFNQEKVTLLNKGWYYQTEDGNE
VEFTTPGKISTSVKKPFEIYTTFHEAMLKEEFLGFRSMQQEVFVSLDDKVIYSFENAGNI
PTFPRAPGSAWHIVKLPEIDSEQVLKISTKSFYSNYQGQISELMLGSKSAILFHIAKTYF
PAVFMSILVLMFAVAVIFYGVYIYRIRRSSNLIYFGLFAFLLGIWFFAESRFIQFFVGNV
LIAYQMVFLSIALMPIPGLLFFSNALQPKNQRFYDALCIVACINFFAMVIAQTLGLVDFF
EWMPISHSIIILSMILFFHTMVECIRNDSYKKSKFVFVGFSVFSFSAMLNIVYFYVSDRF
DSAILLRLGTLLALIIIAKGEVDKNLELIRMGFEAAAYKRAAYTDGLTQLSNRFAFDTTL
KELEQAELDENIDNAICVLDVDGLKYANDTYGHWMGDQLICTMADTIRTVFSEIGKCFRI
GGDEFAVVLQGERDELEGYLDKLSQEIKGNIMNGHCNLSASWGLAFQSDTPGNNIYETFQ
MADAIMYQNKEGKTTTREGNGNPGRSEN
>A0A494RL04|diguanylate cyclase|EC 2.7.7.65|Brevundimonas naejangsanensis|TrEMBL
MPHLTSAVATPSRAPEIQLDPQGMERLRGLVRDHADALVKAFYDVLLEDREAQGFLHHSI
VQERLSPSLRTWLIDLFAPGLDVEGKSFIARQTKIGEVHARIKIPMHLVMAGAAVLKGRI
ADLLADDEARFDQLRLVGERIDAALLLMSQSYVKGTMNRARMDEAYRLFSLDQDIHFERE
SQRASLMEWSQKTLFRILGAGPNEATSALGRSPFGLWIRHRADFLFEASPHLERLNQAID
RIDEDLLPRIDAGDRAESLTALQAGVEEIAFLLNEMFQGLAGLEGGRDPLTRTLNRRFLS
SILSREIGFANANQTPLSVLLLDVDHFKRINDEHGHPAGDEVLRQVAEAVTENVRPSDFV
FRYGGEEFLIVLVETTLQQAVAVAERTRQALEARDIKIGGAERLRVTASIGAAEHGGHPD
ENYLIKTADEALYRAKQAGRNRVEQNG
>A0A0H3CLL6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56)|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRSRPFWQLAVDT
KRTLPINGVSDAFVEKTTLLNRDDELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTETATQTADIIPRYYHLVTQPWFTQQTERNNRARAVLWFITSPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRMLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIENNTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
AQCQAQSLPFSVVQIDLDNFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKEILVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDHDKK
>A0A7L6BPI7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-01013|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A395L3V8|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MEALHTPTIMISSFATLVVFAVFFALASRQERNSLELRLWSCAFLVGALGFTLLALRGPG
YSFVPVSLGNALAVLGLALIWLGLRAFDNQPLKIASALAGPMLWLLITSFSDYVQSSVTS
RIVLFSALIFVYSAMIAVEIFRSDNFRKLPSSYIVAFLFATHGLFYLVRIPLIFVWPLFG
NTASGAEQPVWYQLMTFELFLHSLAGGFSFFALIKERTQHRYKLASETDALTGVPNRRAF
MAKLDAYLATKPAEGALMYMDIDHFKAVNDRYGHATGDKVLIECAAVISQAAGGRAFLAR
MGGEEFSACFPGVYRSQAAVIAEDIRVAFEQAIVRAGNTTLSATVSIGVAFVGSEQEAGE
LLSSADRALYAAKAAGRNSVWATGKDGAPRFVSGLAAKPAEPAPSSGRTERGSMAHCA
>A0A7S7AL15|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. YH12138|TrEMBL
MNQECITGLSQTWKDICDQYTENEHLAALQFIQKHVEHLVTVFYEQMSREPASAEFFKDD
IIQKRLIDTLRKWLLETFNVALNNDFEISVKRQQKVGMVHARVGIPSWLIMRGVREIERK
IFEILELNHTQNILHMCSYIVQIIGFSTEIMCRSYEINTEKKQETKHNYRLFSAMQDVAV
HKDKQRGSLLNWENELMFKIFSGNVSFYHSLLSKSEFGLWFIHKAAYAFSGSDQVQLIID
RIYQVDELTQQTTQITDKDELQHLIQQIRDLNREIQHLVDQLFQVAEYIESGNDSLTQLL
NRRYLSTIISREITFARQNETPLSLLAFDADYFKMINDKFGHAAGDLALKFIAEALQRYS
QGSDYAFRIGGEEFLLLLVDTNVNRAMKVAENIRQYIENGVIRTVQGQQFSLTVSVGCEQ
YNGHPDYQRLLDAADIALYAAKNTGRNRIYVAKTDQQTRSSSS
>A0A8H9CD79|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MMNDEFYDNHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAIIAGVWMGLTGFSALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGSPVVLTSEPLALWLTLPVLVVY
PILFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACR
>A0A427KG62|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MDKEFTSTPRPTFKSTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDALAANETLATLGKQGQFAVAEVINVHKKRFAYWSWNPEDNNDTLGALVS
RWLFPNPVAQPIMHNGNAIGEIRLTARDNLISHFIWLSFAVLTGCILFATAVALTITHSL
HQGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRSSIAALMNDTSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVQSAAEVQQICAALSQQFMRPFDL
HNGQTATMSLSIGFALAWESASVEALLEQADRNMYQDKNQRTKAIT
>A0A1U7MI02|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MIFSEFEEFFQDKCIPVGILGIVGVAFSVKQPWAGIFIPGLLMLILLSILYFQGMEDTEQ
SSRECSYSQDEIKRLLNLVPTPVVLITKADWQLVQLNRAASDLFALAPAVAAGKYMTDFF
GTDQKVWSAWRELLHYGVVQEELPLYRHTGVALVMAVTGNVSLMGKPHLILSMTDITAKH
IEAKRLEQLATIDGMTGLLNRQAFQEKLVLALKAAGEEKRGLCLAYMDLDGLKQVNDTYG
HREGDWYINIFATLLRNGVSENDFVGRVGGDEFAIVFTKCSQQTVEVCIRKMQQQLELTA
SRLEKPYTMQVSVGMIAVPDGENIDVESLLHKADYAMYQQKYVRQPSPVKTTS
>A0A377M8U9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MINVAELFAPNIAPGIAGRLYILDRDPWQMRCVAQWLSPPGEDTPFHPDECWAVRRGQSH
PPVNGEPDIACYHLPASHTHTSLCVPMIAQGEAIGLLSFQNITAENAPSRAYLELMAEAL
GLALANQRLRDALLEKALFDPLTGLRNRHHLEDTLRTQMAQAVRNEEPVSCLMIDIDHFK
SINDRFGHEAGDQVIKSVASIVQRAVHDSGLAFRYGGEEFLVLLSGVDEEAAQACAKEIY
NGVHELSLRYGLSEIGPVDVSIGVASYPQHAQSDNLLRAADVALYRAKELGRSRIVSFGM
LEAG
>A0A1W6KAI3|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MKQIPSINKSGPQPQKLAALRQAHRDWNESPDVLTRLTRRLSTTLSLETQLAILAEEIAS
VVPYDCLTYRHTIASREFVYVTGKGGPHSCDYRLNLEGGFYGTLSLSRRQKFTEQELEGI
ELMLAATICPIRNACQFIAIEQASLTDCLTGVPNKRAMDEALSRASCLGDRHGEQYSLIL
CDLDHFKQVNDQYGHVVGDHMLKLAAAELEKAVRNSDSVYRFGGEEFAILLAHTDEANAR
DVGDRIREFINTIVVNCGDTNVTVTASCGVAMRLADETADQWLARADEALYRAKAHGRNC
TRVFAAISN
>A0A517TB44|diguanylate cyclase|EC 2.7.7.65|Calycomorphotria hydatis|TrEMBL
MHKTLKAIRTHASNWFYPVACTILIVPAMSMGSLYAWSPGIAYAFPAMLLIACASISRHW
PVALLTTATAIMGQAAVILMAFSAEANGEIFSQYCFITACFSAATICLCTARHISHQKQA
QLTALNQAYLEDLIAQNEASDHRLRSQLSNTQGRSASPQRLEEEIISYATMMLSLQDVGR
EVARSANLETLIPTIISTARSALRCRSCSIYFPDENQLNYRNALTPRDRDMDLYVPKWHE
GIGRWVRENGRVFTVDQPSQETEISEACKKENRIPAGIAPLMVGNEFLGLLIIENLEQST
NNLQRLLHIIANISSLAIKNALLFERIELSAKKDGLTDLLNKNSFFAEFEHEAISASRSR
KPFTVILADIDHFKKFNDTYGHVTGDVLLKEFSRIWREVLGAEAISARFGGEEFIALVPN
CDLAQGEEIAEDLRSTVADHMLLHENVLLQVTASFGLTTVDPNQHEGELSSLNPDHVVAQ
ADKALYKAKRDGRNRVTNGGYFKLSREYQQLNETLSAQQLLANGGANGHHV
>A0A240EHN9|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MDAFSLDMRTLNFIIILFSCVYCVGLLLYQRSQQKVAGLTMFSLALLVMGAGPLLISFRG
LLPDSLSIITANMMVTCAFQMILHSLCEFRQAQFKYSYWCMATIPLVCLFFVYFTYFQPS
IENRIVVSAVYLSLVTFASAKVMLIGKQDDLPLAVRTMAMTFILYGLFMVYRGYYAIGES
VAKFMDAGVVHALAFLFSIFLIVAISFSMLWMINGRQVQAIYALSYFDPLTQLGNRRALE
VYIEDDLPKHLSTGTVSIIMLDIDYFKIINDRYGHIVGDKVIRKVSEIIQDSLQPDSATF
RFGGDEIMVVLYDMDLHQARALAERLRNQIETYGSIKGQDFSVSCSFGVAQLVEGEPWDS
LVGRADNALYQAKESGRSQVCSCNLTSSDRCYS
>A0A7Z0VM89|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MGAYPKSREKAGEIFRLTVAFLAKHELIINPVNFSIAYHYVLGEDPALNARLDELLKSDK
GWQEETVEKLFRHYVCNCDEAVLRNLRDELMDIVAHTLGTMIDLTGKTSITNEKIKTHID
TLAESNRIESVMQAVSSIISETRSLVTETNQFETQLLNSTDEVEKLKEELSYARQEAMLD
PLTGVMNRRGFDQTLASMISEVEEQHAANFCLVLIDIDHFKEVNDNHGHLLGDKVLRAVA
ELLNRHTKGKDACARFGGDEFAILLPDIGSSNARNLAEHFRTVIEKIVLKRPNTGSVVGG
ISGSIGVAAFRMGESCEDFLNRCDQALYRSKSLGRNRVTLAD
>A0A411GIE7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWGSISLTYTSINVVEAFTGALLLRKLLPWYNPLQN
LNDWIRVAIGSAVIPPLVGGLLVSLLAPGPEPLRNFFVWVLSEAIGALAVVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVVSLMIARNPVALTTQHVGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIQAINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHNTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELFHALDRRIFNEFFRASAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A110A6R4|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MCKKILLYILYMVEITVLIFVCVDAVGFFRYGSSQSKRGELSELKEGWTLKLGEVIYPIE
ELPKEFVMASDAAMIFRQLPEKINDNSILAFENRFQDVQVKINGEERYTYHGLLPDQGRR
MNTNVLCIVDLEEKDAGQEMKVAFQSPMKTMGLHLPSFFMGTESGLMLESLRAGLSSLVF
SGIMLFFTILCIAMFLREKMGKGEKVEILAHTSLLMVLSSIWSIANCEVVHLCVGNDILL
AYLSFNSFMLLPIMIPIFYSDVLVRYKKFLYRLAGVATFNFLFQNILNFWGKYQYIQMMS
ITYILLLFTIFALIGISIGEYTKEKCYYTAGFLIATIVFLSFYMMDVLRFFFFAPLDNAR
FFRYGVLAFIIIIVWICAKKVLCYVEVEIENRVYKELALRDVLTHLPNRVALEKCIESLE
ERGAVCKNLTVILMDVNGLKPVNDKSGHGAGDRLLCEAAKSIKEAFPEEKDAWYRLGGDE
FVVLMTQTELSNEECQQRMQKATEKWKNFEHGPISISCGSQTARDVKVTKEIVHHLMQEA
DQIMYKNKIQYYQKKLNKRSSQEIL
>A0A381ESY2|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MRSIQISRYSRGIPLLLALLGLLLIASQLMGRLDFWLYDSLTRANPLHKPDQNLIVIAID
EKSLAELGRWPWPRAYHAQLLDKLGGASSIGFDIAIAEPSRDHPEADKHLAEAIRRNGKV
VGPVFPELQGGQLLETRPLPPIASAMAALGHTDYERDDDGTIRRVYLKAGLGAPRYPSFA
AAVCAVSDGRKETIPAPQRPRPGQAWQRRDLVMVPFSSGPKPFHSVSYSDALNRLPASFF
EDSIVLIGVTANGLGNQQPTPVSANNTGMSGVEIDAYMVHGLLTHQQIRPMPLLLECLLG
ALLLGLGDWLLSRRVRARSLLAGYALASAAVLLSSAALLYFASLWAGGSVVAILLLLSGT
MRYVSGQAQLFSLAFTDGLTRLYNRRHFDEAFGHAVEQCRQKRKPLALLILDIDHFKKYN
DHYGHYAGDEALQKVARALKDCFRQKGQLTARLGGEEFGVLLTPGDTPQALSAAERFLGR
LAAMELPHSASPLGKISCSIGVCACIPGPADSTRTLFEQADQALYEAKRGGRNRASLYQD
PPGNGAKKSADISSARQD
>A0A564T797|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A381ERK7|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSFVFTPLAALSGLAALLAAAISVIAWSRRRFAGVRWLALLMASVAFWAAGAMCELSVTS
IAAKLFWSKVEYLGTLSTPVLFLLLALDYNHLSLRRRALALLFAIPAICLLLAASNEYHH
LVWTRFQPSPSGYNLLVYGHGPAFWLGVAGYSYLMMLLGSLLLIRALHYFPAHFRGQSLT
LMLSAIAPWFGNILYLTGAFPLQGLDPTPHAFAFTGLIFAIDLLYLRQLHLVPVARARAF
EAMGDGVVVVDHQLRILDINPSGAGMLGGAPADWPGQPLPAPWLEASMLAPGAHLELMPP
DGGRILDVRIYDIEPFHKPARTRMLVMRDITLRRQAEDALREANLQLTDRLAQIEALQAA
LREQTLRDPLTHLFNRRYLDETFERERERERAEREGKPIAVAMLDLDDFKRINDRHGHQI
GDRVLQALAGLLRQRSRAADIVCRLGGEEFMVVLPGSDAEQAQHRVEEWRRAFHQMEHAG
EHPFRASFSCGIAALPGNGRVLDELYRRADQALYQAKAAGKNCSVRAGRG
>A0A447TEK5|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSGFYVMIWDITQSRAREIELRSQVTQDAMTGLLNRAAFMDILNDEIKHHYLKRQALALL
FLDIDHFKQVNDTLGHAAGDELIKIFARRLRQNVRGTDHVARLGGDEFVVLLVGLDAERT
ATAVVDKLMAAVCRDAELAASHTASPPA
>A0A1V5ED84|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MDANVTEGRRFARRVYHPRIIGLSLGFLCAASVLYQKDAPAVTWLGLVVNTFVWPHLAYL
LAISSGNPRRAETRNLMLDSFFGGLWIPLISFNLLPSATFVFMLSMDKLAVGGVRFFARG
LAALAAGILVSLLLFGFDFRPESTMLNVLACLPILGLYSLSVGIATHRFAQKLNRQKGEI
EKINVALQESHARLTEAYERMMENDHRYRLISENAGDVIWLWDLANNCYSYVSPSVTRLH
GFTVDEVMRQTMADALPPDSLRILMTEMPRRLQALEAGDETARAQSYEMMHFRKDGTLVP
TEVMTTVITDEQGNPMLIQGITRDISSRKEVEAKLRESKAQLDLALTSARMGTWYIDLID
QRRHPDKRACELLDIDPAQFKGELAEFMQVVHPDDRQKVRDAVARTIEMGELYELEYRIV
RRNGDIRYISTRGMLVRDDAGRPVRINGVLWDSTEKKRTEQALQESERKFRDLSEKSMVG
VYLVQDNVYKYANAEFARIFGYGVEEITDKIELKDLIHPDDLPLVEENIQRRISGELQSL
SYGFRICTKSGEIRHVEVHSSRTSYRGKSAVIGSLLDVTNRKRMEEALRESEEKYRSIFE
NAKEGIFQSTPEGRFLRVNPAMARTWGYASPEEMIKQVVDLNKQHYVDPQDREHFKAVMA
EQGSVEGWKVEIYRKDRARIWVSLNVRAVYDDAGRIIYYEGTNEDITEQKLMEDMIRENE
RRYRHLVENSNDIIFTTDLSGILTYVNPATERISGYAVSQLYGKDFFKLVRADYHERLKC
LYRRQLDEKGATTYYEFPIVTSDGQERWIGQQMQLIYEKTEAVGFQATARDITDRLKAEE
EHRQREKLGAIIEMAGGVCHEMNQPLQIIYGLSDLMTIRTPKDNPLYPQIMDIKNAVERM
SAITKRLTGITRYETKQYAGDRKIVDIDKSSHE
>A0A1Y0HHD6|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MASLLTNDEKAWLLAHPTLNVGMDSEYAPYEWVNKNGDYVGMAVDYLHLLEKKLGIHFKI
AKGKSWSEVVELAKKGEIDVLTSIVQTPERLQYFLFSEPYRDTQTMIVDNGEGKFIGNLE
HLSGRSVAVEKGYFTQELLKTKYPNIKIVLANTILEALTSVMERKADAYVGDMSAINYAI
KNNGLAKLRISGQTEFSSQHRFAFSKNNPMLATIMTKAMASISAEESDAIFNRWIGMRIE
QGIQAKTLLKYSVGLACLFILFGYWYYRLHCEIKHRQAAEMREHHRNTVLEMIAKMLPLS
KILESIVQNVEEQNPKMLCSILLLDSEGKFFSQVIAPRLPTFYNEAIQGVSIGLGVGSCG
SAAYLKKRVIAENIDTHVYWQPYKEIALRAGLQSCWSEPILSSSGDILGTFAIYHTCPQT
PITTDIAIIEQSANLASIAIEKSISAIKLKESEELYRRLTEEVTDVIWKVDRDLKITYIS
PADEKFRGYRADEVIGHHVFEMFAPESIKIISEKIKQRFEAQQKGMRTEEFVTYEIQHRC
KDGKLIWGEIISKPEYNASGEIIGFHGITREITERKAMQDRVQQLAFYDSLTKLPNRILL
SERLSYMLAEMKRIQKYSALFFLDLDNFKSLNDTYGHSIGDLLLCQVAQRLQKCVREMDT
VARFGGDEFVVILNTLHEDNQVSVEQAHRIAEKILQSLSALYVLNVSHDKSQEKLVEHKC
TASIGVLVFKSAEKTPDDLLKQADAAMYKAKEAGKNKISFYEAPF
>A0A4Q9AMY2|diguanylate cyclase|EC 2.7.7.65|Rhizobium leguminosarum|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPTDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLTRAGEGRADETAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKHVNDTYGHDGGDEVLREFSNRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAIENAPFMLKHAGEALNVTASFGI
ASRITSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A737ISS9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:b:1,5|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRTCASDATQEREKK
>A0A1V4IIW2|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MNLVLRIDNNVVAIIVSIIFLINISNNLDRKETKNKAFSTIFILNTIELTVETLTCIINR
QPYLWLIPITTLLHIVLYILAPIVTYNWYMFTGLWINSNTNAKRKKNLLLLLPIIVNTFL
VLLSPFFKLEFYINQHNIYARGPLFFIPAAISYLYLFCGFINIYTNRKKLRKIEFKPMFL
FGVFPSLASLVQLLFYGPLLMWSSITFSLIILYLFLQQQMMHVDYLTGAWTREKLYHYLC
SRIEQKKQKVFSLVFIDINDFKKINDAFGHGEGDIALVNLVHIMKSQLRQEDIIIRYGGD
EFILILNVETEHEAEAIIRRISKAVKENNSSSKKEYELSFSYGYELYNFDKPMTPEEYIN
HVDRLMYLNKSNKKLDINSK
>A0A7L7IRF8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00175|TrEMBL
MMNDENFYNSESIREEWHHNLSQDDPHRSGTQFARRVRLARMVGLGAMFFPISGVLVTHS
LPGGWWLLLVGWAFLWPHLAWQLACRSPDPFNREMYNLKVDAIIAGIWIGLMGVNALPTA
ALVMMIGMNMMGSGGCRLFLTGVAMTVLTALATLQLTGLVITFSPQPLEWWLTLPILVLY
PMLFAWVSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRYWETLLRNEYENCRRSQRTATI
LLIDIDHFKNINDTWGHDVGDEAIIAITRQLQLTLRAGDYIGRFGGDEFAVIMSGTTSES
AIAAMSRVHERLTKLSLRGAPAERLRISVGVAPWGPQFGHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A8J7VSZ1|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MTPGFPPIPLRPGAPSARPADARVLLVENSRMFSEVLATALRERLGVEVVTAGSLAQARR
ALAEQGPFFLVLTGLVLADGDQSAVVETFVGQGLPTVIVTGVFDEAVRQRLLGRSIVDYV
LKDTPGAVDYLVWLVQRLERNRRITALVVDDSPSARQLAGALLGLYGFHVRAAASGAEAL
AALARDPSIRLVIADYEMPGMSGIEFLRRLRTRRARDSVAVIGVSGSNHSSLVAEFLKSG
ANDFLHKPFSREEFFCRISQNVDSLELIGSLQDLATRDFLTGLANRRHLFERGGALIQEA
RQRGEPVALAMLDIDFFKRVNDGYGHDCGDMVIRAVAEAVDGHARAGDVAARFGGEEFCV
LAPGLEGELAEIFFDALRARIEALALRFEEHEVAVTISVGVVTATRGTLNEMLLEADRRL
YLAKAAGRNRVVAAGASDEAAA
>Q0T037|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2N7RHN8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MVNNNQKDSSLAQWPEAAQTLMALMHAQGEVARLSEREQLFSSLLVSVNAVLWAFNWETR
QVLYVSPAYERIFGRSAGLLLADYNQWRDSIYPDDLEYAERSLAEVLHKGAVEDREYRII
AADGQVRWLSDKCFINRQDEPGQPVIIVGIAEDITDKKHMETELQRLATTDVLTQSSNRR
HFFECANREFEEARLQGSPLAFLLLDIDDFKLINDSYGHPEGDNVLQRIAECGRGSLRRG
DLFGRIGGEEFAAVFPGCAPDMAMQVAERLQQEIQRLSFSHDGQTFGITVSQGLTSLKEG
DDSLDSLFARADAAMYEAKRQGKNRIISA
>A0A3Q9E6K2|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MIARQGFLFLILMLCSLLASAQPIKLADLPDGPLTREWMQLSEHQSPLTPTMAQQAFADG
KFSPHGKGIPSLGIGARPLWLALEVDNDSAADTVRVFQLANGWQDDIRLTQIRPDGNRFY
WRGGDTLESGKGDRFFSVPLTLTPGTHLLLVRVGGPDPRVLPVFLSSLYETQKRERIEAY
TYGFLYGGIFALLGYNFLLYLGIGSRSYLYYSLFLMTFLVLNFSYSGHGTAWAWSGMAHW
RQWSNPLLMTLYCVSGLMFALRFLGIDKLRPHLSKIVIGLALLMIVLQAVSFGIDDRELA
LILAFDLVYVFTVLMPILGILAWRSGMPTAKLFLLASLSTMIGMGTTALAVEGDIPFNQW
TYRAAEIGMFIDAVLLALALAAKFRRAEKARVLAQQLASTDPLTGIDNRRAFTNRLQSNW
DNNALNRCRALLMVDIDKFKNINDTLGHDAGDKVLMAIARTVRHSIRNRDFCGRWGGEEF
VVYLPSASEAEINAIAERLRANIAGLKFPGISDKLRVSASIGVCLDQGFSEYEDILRRAD
EAMYSAKAAGGNRIKFA
>A0A644WE75|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MKLAFKSSLLICMLLLGAGYGLLYHFIIMPLIGSELVHCLGQGVIFGLINYFMSIGLYKK
YHILKNSNKLLKKNLNIDKLTGLLNRRAFDNDIIELPLDESYSIIFIDIDNFRKFNNKFG
HQVGDIVLQKVSREISNSIRVSDKAYRYGGEEIVILLKDCNRRKALEIAEKVRLNINELN
NNPYPSITISLGVASYPDDGKHADEIIKASDNALLTAKRLGKNQVSSCAI
>A0A2P2EAC8|diguanylate cyclase|EC 2.7.7.65|Candidatus Phycosocius bacilliformis|TrEMBL
MSQVACGRVHVLYNGSVPVRRRRVCSGLGASGLSFAQHQGEGRPAAAVSSLQPKLALERA
TQAAVAAKKTRTQRPSHADHSPEGSTRDVAAPAQADRPAVLGIPAAELTPHVRRALKHLS
DQVASLQADRARLMDRLRQAEELADRDTLVPVFNRRAFERELNRIISFANRYEVQASLVY
FDLDGFKQINDRFGHPAGDAVLLAVGETLTANIRESDLVGRVGGDEFAVILAKAGPEDAR
RKAAQLADAISRCEINYLGHRLKIAAAYGSYCFERDDTGERALSRADEAMYANKVGRKIQ
SL
>A0A0U1HX26|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MLSTYLDALNILSTPVWIVLPKNQEIVFANKEARKITGDSALPLMRNGRFSAHAQQQLDA
YLPALAGLDQIIEIWTIEKKEASFPLSCQLSLIQLAPYGDVIVFEGLFISSSVLAKPHAE
QLFSKPYYRDERGFYEQFFNTNTAPMLLIDPSREGLIVDANLAATRFYGYSRDEMCSKHT
WEINTMGRDVLPVMNEVAKLPGGHKPFNFIHILADGNTRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTNLGNRRQFFPLVEQAYTQSQRYNQNFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIVRESDSVFRWGGEEFAILLPLTNLQGALQLAESIR
ETIQMICQPNLPTLTVSLGVAQHQVGEDTDSLFKRMDEALYRAKAAGRNRVLAAA
>A0A822PMA9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVS
DALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTL
FTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYW
YGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALL
AQAMEHDTRGGIRMDSRYVSWERLDHFDGVLARVHTLSEGVRGDFGSISIALTLLWALFT
TMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPF
SVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGANL
TQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLA
KQAGRNRVFASDNA
>A0A7W3GL18|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00271|TrEMBL
MFPNTMNDENFYQKKAVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAEDPLYSEFTNIKADAILAGMWVGIMGANL
LPSTALLMIICINLMGAGGVRLFIAGVVLMVVSCLVTLQLTDIPVVFSSTQLSVLLSLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRQQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PAASAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NAGRNRTEAAA
>A0A0H6T4M9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNDKVLESVIEITEQKNSLALSYSILATLSELLPLSTATLFHHLGRSTLMVARLIITKNA
AGKKEYQWQYDQVCADNGYQHSQSEMAFSQQANGQYQCFCPIPIEEHFSAELCLILNKDP
EPYRMLINGFAKIYRNYTVILHESERDKLTGLLNRRTLEDRLRHTFAINPSTEENHKLWI
AMLDIDHFKAINDHFGHMIGDEILLMFAQQMQHYFGPSSQLFRFGGEEFVIIFSSGNEPQ
IKQQLDGFRQQIRRHNFPRIGELSFSAGFCSLRPGDYLPTILDHADKALYYAKEHGRNQV
HCYEQLCENGKIASAQRPFSDDVELF
>A0A5I6RZ16|diguanylate cyclase|EC 2.7.7.65|Salmonella potsdam|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAERLQELADRNMYQAKHRRAERSLN
>A0A142CNL5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1|TrEMBL
MNNDGCVIARSPEAKALGIRMGQPWFQVRQMRLEKKIHVFSSNYALYHSMSQRVMAVLES
LSPAVEPYSIDEMFIDLRGINHCISPEFFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQ
WATKQWPQFSGVVALTAENRNRILKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQA
NTAFIRKNFSVILERTVRELNGESCISLEEAPPAKQQIVCSRSFGERITDKDAMHQAVAQ
YAERAAEKLRGERQYCRQVTTFVRTSPFAVKEPCYSNAAVEKLPLPTQDSRDIIAAACRA
LNHVWREGYRYMKAGVMLADFTPSGIAQPGLFDEIQPRKNSEKLMKTLDELNQSGKGKVW
FAGRGTAPEWQMKREMLSPAYTTRWTDLPVAQL
>A0A3U7XKI1|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1T3AKS8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKSPTQTNAIDFDSAKLQRLGFGQPALLPRRPATLAQLHQQLSQQLQTSLEPERILALFF
REVQRLVPLDALQYRHEASDLRLEFGHRGHHSVSYTLSHEGEHLGELIFRRNQRLMEDEL
GQLESLLSTLLYPMRNALLYRAATRSALRDPLTDTGNRIAMDQTLQREIDMARRHLSPLS
LLMLDIDHFKKINDTHGHAAGDIVLRAVAGSIKSQLRNVDMVFRFGGEEFLILLSNTGRD
AAGMVGERLRRAAQVQDYWADGKRIELTVSLGCSTLLAAESAESLLRRADNALYVAKREG
RNRLAMAG
>A0A1C6I6F5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MMNDTAKRRRIKIGLLVSHLEDDFDDAVAEGAMIGAEQCDADLVIFPGRYIDGIYADKLR
TVYEYQYNTLFDMAAANKFDVLLVLIGTLGTYLDNEHKVQFLKKFAGTPVITITAHIDGY
PCIMLDNRTGMKEAIEHLIKVHGCKKIGMVSGPKTSDDALERLDVYKETLKENGIIYDEK
RVAYGNFSKFCVDEVGTLIDDNPELDAIVFANDQMAIAGYKAMEERGIRPGKDILVTGFD
DDPVAEELNPHLTTVKADPSELGYHAVQEAVNYVINKAINNDKISSEMVRRNSCGCQGNS
KLKTISFGRISDDPEAFARRMSQFLFNKYSASETTAKMREVYVKIIYALDDYAREENLDN
EIKKDKVLEMVSTLASEEFFRFVNVDELYASVEYIQQKLISRFDNVEKHLKLNQTFIQIY
KILAERNANYCKEKLEDNEFLAWQANSITRDMLVFEAYDDRAYETVVDKLMRLHMESSFL
FSFEPAIIHFGTDKWQPPEYMYLKAYHNGSDAIQLPHEEQAVKYTELLSNKYLPTDRRYT
LVVSPLFSNEEHYGILMCEIKHEYFNYLQSVTVQLCAALKIITLMKQQAVTQKQLKKSLI
EIKENNELLRDLSRQDALTGCYNRRGFFEELRKRLSNDKNEGEKAIMVFADLDCLKTIND
KFGHEEGDFAILSAAKILKHSFGNSEIVGRIGGDEFVVCAFLDNAIDIPSMRNHIEAVTR
EYNIKYAADKPYIIHTSVGVYPFVCSATLEIGELLSHADILLYEEKKHKRSILKSDYE
>A0A0H9X590|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALNCRLVLRKLTEAEPVIIFEGIEASATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0W0U6J6|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MSDKIDEKELPFKSVLDQTDDVVIITEVEPLNEPFGPKILYVNNAFTTLTGYTQEEVLGK
TPRILQGDKTDKNTLKRIRTALEKKEAIHVELLNYAKDQTEYWLDFTIIPIKDSKGRIQY
FAAIEHDITERKKLEDAKAMLSALVEFSGEAIIGKNLEGIIQSWNKAARNLYGYTEKEAI
DANIKMLFPKERQGELQDIMDKIVRDEHIKGFETVRMHKDGHIIPVSLTIAPIKNARGKI
IGASTTARDITQQKINEEKLKHLAEHDVLTGLINRPLFEDRMVQALAIAKRTNCNMAVCF
LDIDGFKNINDTYGHNIGDLVLCTAAKCMQKCIRDIDTLARFGGDEFALILSYLNEEKDV
IKIVKKLIHLFSKGFLIENYKLKVTLSIGISLYPRDGMNDLLKKADAAMYYVKKHGKNNF
IFFNAIDKD
>A0A1F2Q5V1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MGVSGAAGLGQNIRQTTGLLRRWWSLAYDGEWFPRFLAARSMLGTARVVVTFWCAVFVAL
AVLAQFVKGGATDLPERLAAGAACMIALYCMIRWSLGRSWPSHHQSVRFISLTNICLSLI
LLAGIHSSFLALTGAVLFVVVANYSSVFHSPRIVTAQIVGALFVVALLTIRAVTDPDTDS
SLSVSTGFVIGCVIASAAMTVHFLVLYLTDDARHSWRDPLTAALNRRGLHNVWQQLFGVG
ELQGHVVLAVVIDVDSFKSVNDKLGHAEGDRMLVTVGRRLNSAVGEVGLVARTGGDEFVI
LMPVEPRRIEQTVVDIHNSISRPAGRQSISVSVGASVWLSSTIPDASGTIDRILADADNA
MYRAKRRGGDQVAWAVTHLS
>A0A0H5BBI5|diguanylate cyclase|EC 2.7.7.65|Blastochloris viridis|TrEMBL
MDGGKSEQHRLHQQDRDLDAGAPRREVSTARQAPQPEDARRLPQPTQSLVMQLMTEVERL
EGELATARAEARALAARAEEDPLTGLANRRGFARELARTVSYVQRYGASAALFYIDLDGF
KAINDRRGHAAGDAVLTAVSATLVSHVRASDRIARLGGDEFALILWNIRPDDAERKARAL
EEMIAALPAGRNEAGEPELGASVGVTMITGDDTPAVAEARADRAMYVRKNARGGGR
>A0A5F1BIQ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0D6IIM2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRTDKPPLKQRALQKLLLRRFGMAAGTYLLGLVLLWLALLSGFYRAAPTTAAASTTLVVA
CQLAFLWLFASGRNLRYADPSLTEPQVLVAIAWLTYFLYHVDSLRGTFMVFYVLALLFGV
FQLPPRVFARCAALAFIAFSGIYLVEALQQRLELPGRAALQVLVMFIVMVWLSLFASYIQ
AMRQRMRQRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFMRMASRALEDLLPNR
QHGLALIDLDHFKRINDRHGHAAGDRVLQTFAAVARSCLRDGDVLARYGGEEFVLLLPHA
DAEQLESCCERLRLAFQQAEPVGVTVDTLSLSVGMTLLYADDDLDEALQRADQALYRAKR
GGRNRCDATWEVTSA
>A0A0T6RH99|diguanylate cyclase|EC 2.7.7.65|Aeromonas veronii|TrEMBL
MSKDTFAQSAAYLKQAVPLMIKYQIPTTPDNYHLWYNYVSASMPELNQAIDQAVKMQGTC
SLTTCERLYHQYLAAQDEKQMEAMKLSLAAMANELGHSMQDAISDTGMFQEMLDKSFDKL
SRIDDEGFSLEDTMGILRELVRESRDVRMSTMHFRNQLSNAEKEIKELRAALNETRKLAN
EDALTNLLNRRAFDLELEGLIRSQHPFSLILADIDRFKNFNDEYGHLLGDQVLRAFSKRL
RDACKEGVTAYRLGGEEFAMLVPHRSLALARQMAESMRRAIERMSILDRKSGRRIDHITA
SFGVGEFNGQESADCLVERTDKLLYKAKELGRNRVMPLPS
>A0A5W6PNB2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Albany|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A726UL09|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERDLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6Y2UIJ2|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTCQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A285AX61|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSKAILVDGRQKPFASWHNERLVRQDKISDVIS
KWLFPDPTVQPIWHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVHSSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAILLRDVHSETEVQALCRALSEQFIQPFNL
HNGHTTSLSLSIGYALTWEHASAENLQELADQNMYRMKHQRLQQTQK
>A0A0M6WEG8|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MDIDNFKSVNDTLGHAGGDEALKLLADTMRLVFGTHVLMARFGGDEFVLCIQNRDQEGVQ
AQLDKLVRSTCQTFTYGGCSVPLSISLVLCI
>A0A5I9U046|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X4TKD8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MSSRDGMTGVYNRRHREILLRNESDHCRRHYQEATLLIIDIDHFKSINDTWGMVLGMRLL
SP
>A0A0D6GVL3|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVSTRLHKGMKGWLKGLLCVREQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALGQIIEAVARLDDVVLPRLLQGSPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATREHSTFSVLLLDIDHFKAINDSHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTAREAALAAAEKLGGEIRRHAF
AIPEAGSLRITASIGVATFDGHPDYAYLIDRADKALYQAKQAGRDRSVAG
>A0A0J0GQD5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLFFRQGMHDAIETPLAFEVLQDAVSRFNTVRMLPTWQIAVDK
KRTLPINGVSDVFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTLDQAGDITSRYYHLVTQPWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDRYWYGVVAMDFTLSTMQRLLADATEDRTEGEYQLYDTRLNMIATSARTGNAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A729ASD8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:d:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A155J1I0|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MALHSKKLSFTRPIMLSFAGILCSFAVIAIAVTLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRSAMYFARDDRLNETLNLNPTQGLQMVMHLQNLMPTVSSISLADTQGH
YLRAPEVLPTEKSKTFDPRTRPWFVAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPE
GRLKGTIAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRSVLMHIINAIKTGDVNEAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDSDIAELLNAQQPFAMALVDIDNFKSINDTLGHLTGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFAVIFQAEQMSSALSLLEAWRTAVEKRVWREENLRVTFSGGLGEW
HFEPLEQFVGSVDNALYSAKQQGKNRIVRTSIS
>A0A517Q0K1|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKDPDTDIKEVIDTIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITHGPLKSRYDSYWKQSIIQSAAAEL
LSSRLGNELKYDAFLIGLLQDLGHLAMLRSIPNDLLPVLEQAETEQRETAEVETQVLGVN
HAEVGVKMMERWQMSEQFQIAIQHHHDTFEQLKALETNPDFNLIIIIAASASIGDYFCSP
NSGLALQRLQQLMTEFYNMPSDDLHGFLEEVQSRFEEAAQIFQVNMDDIESPYEIMAKAN
EQLVQLTMKAQVDSTQAFARQAAIEEQKVKLESENKQLQSKAVHDPLTKTYNRSYFNEAF
EKELHRCARSAQPIGIIFSDIDRFKSLNDTYGHQFGDLVLQRVAKVASESTRRSDVFCRY
GGEEFVIMVNNPSENGIRELAERLRKLIENEVIEFEGKRVPVTASLGAVVGIPPRDMTGY
GERLIAEADEAMYNSKENGRNQVHVRSIITQADNELQKLVKRSRFSRWLVTKKIFDIPTI
SKALLKCPQQETLTKIGELAVNEKLLTTDQVTEILELQQKNGERFGEIAIQNKLLSREQV
AYLLALQIEPPIVLGKTLISLEMLQSAETAELVKLYLSEFKASPAPIEERRSDFANS
>A0A600WZ45|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2X2C6N9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MLMMAIPQWQENLQHIRHLRLFRDVDLSHLEKLARTLTKRVLNPGEMLLSPSEHNHYLYM
IVQGRFRVHLESLDNQPVSVLSEGDCAGEVSFLDNHKPTAYVIADEVCEVIGLHRKDLFQ
LMEHSPKTTQNLLEILCERVRQNNRIILDTERNANVDTLTGLFNRRRLEQLYERESTRCA
FNQQPLCLLMLDVDHFKRYNDTYGHLAGDYALCMVANTLRSQLRPKDSMSRYGGEEFVIL
LPELDKPEARMIGERLRESLASIADFYSPAGKLPGVTISIGLAEMHKQDTLETHIERADK
ALYEAKRNGRNCLFG
>A0A3Y4MXR3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMLLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDAGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5F1I1G7|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSTSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHGHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A0U4HH34|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MPTALSAINTRRAGLNFARRLYLPRIVGLGIGFLCVLTALYPVHQPVGVWILLAVNGFIW
PHVAYQWSIRSEAPYATEIRNLLIDALLGGMWVAIMGFNALPAVVILSMMGMNNIASGGP
SLYFKGLIAQIIGALVTSAILGFPFTPQSTPLQVYLCLPMIFIYPVFLGYVTYQTAKRLA
EKQQELLRISTRDGLTGVFNRRHWEHLLHNEFDSCRRYNHPATLILMDIDHFKAINDTFG
HGLGDEALIVLAEELVLGLRAMDIVGRYGGDEFGAVLPNTSAEQASLALHRIQERLNEVV
FREAPGLKLNISAGVADYQPEMPGYQEWLKAADTALYRAKNNGRNRQELAVHQC
>A0A401AVB4|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A483GH36|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFITVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1C3K782|diguanylate cyclase|EC 2.7.7.65|Orrella dioscoreae|TrEMBL
MKHSTEVMALDWAHTHSRYSAEQCQLAQDVSARHTAALADDFYDCMLADQGAAFFLSHEL
VQTRLRHAMQEWLLTVFDARHLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLTRRM
HELLHAEPDALPHAVLGACRYISEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSANLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHHPPGSAQRAQALQGIRDATQAVAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPLSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGPQALSVADALRRRVQERPVALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAEDDTDMPSGAPASHAAGHQPVRAGA
R
>A0A485T8H1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRGRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEEIHTECSAIM
QDADERMYEIKKGKR
>A0A377ZU25|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLRLVQELSFFWPLNAVMAGIFARYVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLI
NFSNIVFIVTLAQLVLWDKRRADSMPGPINALNLFCFCLLAALLCAAVGALGSVDVERAT
FVPQLADWFSEQFSTAVLILPFILTLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAG
SITFPLPALIWCAVRYPLPLTCLLTFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLG
IAAMLISPVIVASSVEAINTLVKQLALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTV
MVLDIDGFKRVNDALGHEGGDCVLTQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQ
GYLLAEKIRHGVESQPFGLGQNPIHLTISLGLETREVGHARITELFNQLLLAADDEMVKA
KQSGRNQICMPTLTESAP
>A0A7W2UZY5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRETAEIDSILMELNHSIDAHYKWLVKMFHCVVLSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRNLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RVTTQA
>A0A1W2IPB6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A1M0D3I1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLLLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A0A1ABV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAATNSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQTAKAIASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A417ZWS3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGELFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A827XKC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQRRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A244BTV2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A8H1T0L2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRSLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2X6WFU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGTWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A0L7AGD1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPMLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A061YJQ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTVRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3K1WSD3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8F6WZ77|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A0J3YR01|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7A3AZW8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQASMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A7B5VCV2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRKDYFGIGSTVFVSLLFGLAFILVNSWFHQPTVKETVPQSTYLMVMIALFVIDIIAFIF
MQLYFIYDRRQFSNCILGLAFLSCLIYFIKTVIIIQQPIEGGLTNSIIQNDTAIYYFFRQ
VSLCLLINLALVIKLNEKNDLCERWHKRIVFYISVIFIVGLPIIAFIFSSQCENYSLTIA
ELLNKNGRVVWKTSYVIMLIFMWLMLLAVNLYFNRLRSDIWNGVSVIAFCAVLYNVSLLF
IGRYSVSIWYISRTIELFSKLTVMAIFMCHVFSALRVTKDIAHRDPLTNIFNRNYFFNEL
KNQSALAKKKPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVKIIGKSIRPNDLLARVGG
EEFGVMLTEIDHENAEALAERIRANVERLTGDNPEYAIPQKVTISIGAVVVHGNTLKPNE
IYRLADNALYNAKEAGRNKVVGFVE
>A0A8H0RWF0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELRKASL
>A0A061YC69|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
TNYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3K2YFV5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCINMAMKITFMNPVAEKMSGWTQEEALGVPL
LMVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLGSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A370V3R1|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQSVITRV
>A0A376FQB4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEILHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2B7LLH4|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVS
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEYEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKGGKPVVGDEYNAKNAIFTVSEAMEHFTYLPTGLYVFAYKKDVYFQVCTLIIFFAALVA
AISGISCMYLVRRVINRGIVEKEAIINNHFDRVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A4D9Z6L8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYSVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRSDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A853T6B5|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MRAAISESGLEPDLFTVEAAALAAARRMHADANASGAEQRRVLGELIVHYERLMRETRRL
IGRSDRAERDMHLLNRQLQTLAGQLEYRATHDPLTGALNRGAVIDHASRCLAQGDMALIV
LDIDLFKQVNDDFGHPAGDGVIQAVVDCLKGLLGQETAIGRVGGEEFSVVWPTSSRDEAA
QVAQRICETVGRQRHAAPITRAITISVGLSWNRAGTPFETAYSHADQALYQAKREGRNCV
RQWLES
>A0A659NJJ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Wilhelmsburg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSMTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2U2VNI4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8G2E9M7|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNRPSASSTLRTPLFFIVSILALFCLINFTTTYINTITTPAPLLFYGMTLIILIFYFLIS
ITIALKYLSDKRCLFLIPVACAFIGSAIMMILALQNYSKLFYCNLNDSISYNEFLRYYFY
RNALTLTQITTAALVSRFRSHRLLASHNHIIITFACISLTLAIVLIVGFSSMHLYEPTIR
LASNIMVYMWTLLFFTTIALTRFRNIFWTGIYFYCFVYILTFSFLTTADVASENTWYKAR
LFETLGTLIFIIIIFLNAFKLYQLSNNKYENAYQNSIRDYLTQLYNRRYFYLALTKKMQR
VSVQKPLSILLCDIDHFKRINDKYGHFQGDLVIQYVAWVLQDQVRRDDIVARTGGEEFAL
LLPDVGQLQAQLIAERIRQAIISPGDVSSRVKLPESVTISIGLATTEDPKTVETELLNRA
DDALYLAKKAGRNCVVAWQKSSCTR
>A0A1D8UYP2|diguanylate cyclase|EC 2.7.7.65|Kozakia baliensis|TrEMBL
MKNQEDLFGDEWERLIHSTKENIRSELAELVQYNVEDCIAEFYDSLLNHPEAKNFLSLEL
VDVRLRTALKRWLIELFSADKPSAKKLVATQYKIGVAHARIHLPIHLVMQGARSIKNVLR
NHLQTRSLSKAELYACVVYTDDMIDLAIECMSQTFVQETCKEVEKDEAFRQASIGQDVSL
EREVQRAALWEWGQTFLFGLYSGATRPQTTLEGSDFGLWFNHKGSALFHNAIETEKVRRC
IHRIDRELSPAILAAQPPNPSLLNEIQSTLDEIRFLMSELFKVIETVESGRDPLTKALNR
RFLSTILSREVSLSLRRATPFSVLMIDVDHFKDINEKLGHVGGDTVLRNVAEILINSCRS
SDFVFRYGGEEFLIVLIETAAPHAEQVAERIRRAIESSPKLTVNGQGIDVTASIGIATFG
GHPDYSFLVEAADRALYLAKAEGRNRCKIAYG
>A0A4U9HRP3|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MSDIILARVSETLSTEQSLESLVRQLLEMLEVVTDMESTYLTKIDINARLQHILYARNSK
KMEIPEGLSVPWGETLCKRAIDSNCFFSNNVAEHWDDCDAVHALGITTYMSIPIHLTDGT
LYGTLCAASSSKHQLSERGEHVLKLFAGLIAQYIEKESLVRQLREANAALIAYSYTDALT
GLPNRRAIFENLTTLFSLARHLNRNAIIAYIDLDDFKLINDRFGHEAGDRFLVEVGKRLN
DGRGDDDIVGRLGGDEFLVACLSQDRESAEQTSLTLVRTQLSAQIAGEYWLGDLHLVYPG
ASLGVIEVDPAEIDADSALRAADAAMYSDKKGKLKTPFLNID
>A0A0H2WR45|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A (strain ATCC 9150 / SARB42)|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8E6Q610|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A210XZC4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSNSAELNELHWLLAIVQSIDVGVVVLDRDYRVEVWNTFMENRSGLHPEKARGQTFFNLF
PEVDEDWFRRKVESVMTLGTPSFTIWEQRPYLLRFKNYQPITGLEDFMYQNTTLLPLKGI
NGSIDQVCLIIYDVTDVAVNRRQLQAANAELQRLSSTDRLTGLYNRGHWEEMLRLDYARH
RRYDSQAALVMFDIDHFKSINDTYGHQVGDAVIQQVAELIRENLRDSDVAGRYGGEEFVV
LLPDTDKQGALTFAERLRHAVESHEVQHEQHRIRFTISLGVADLSVPSSSHAQLIEWADS
ALYASKAAGRNRVTLHQH
>A0A5T3I100|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A736UZP7|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U1KVZ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDCERALLAREIGKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V0UB43|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNEENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V4F6R6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379Q9K5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMGMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5T4ISH5|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A174BYA2|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MQTNKKNKNIIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREVKLE
ITGNQNDELIKYLDDILLGLRYQDGHYNLVKLNDEEYQGKLKIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAIKIRTIELLSALDMLILVILVIMQTL
KAMQMAMQNRLLEQKAFVDAPTGLPNKNACNELLNRKDIITGSTACIMFDLNNLKAVNDT
MGHSAGDQLIMNFSKFLRSVIPEKDFVGRYGGDEFIAVIYHTNEAEIKEILKGLYREKDR
LNSYENQIPIDYACGWALSSDNMSCTMQMLLDDADANMYKNKQLCKKYN
>A0A752E9F8|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A736MLU5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLVSCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1B9ET70|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. PTY087I2|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQSVVDGIVAGLGYELACVNLVRPEGD
LVIAAFAGNAAAEALITGRVGSRDSWNRRLSMGEAWGSLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASAGGGDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQQGRLLR
TNDALCRLLGRPASVMRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICER
PNSSPAATAIEALDAAYGDVESSLTHGYQADGYEGEAIPGGGPFDHHVHTVAPDPEHDDG
TKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLAD
GLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVE
KRSRSKVHRRAG
>A0A8G1HWN0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MLTRRRSSLAGFIFLAVGLVVFSALLLLKSETERREKRFSEYVQNISGIVRNQLDTNEAV
LAGFSAFLQAVDQSDTEAAARYAAVVLAAYPHIYMLEAARAVPIAEQAAFEDLLRRTWRP
DFQLKDFPSLTHQPAQHQVYLNETWPVLFMYPLLPESSSIYGVKLETVAYLSYALARTHN
NQKPVVSPVFSMYEGGNAYILMQSVIRPEQDRGNTRPNFFGSTMVSLLLIKTDSLQEAVS
YANVDPLVRVSAVLKTAAGSESNVFSTQTEQACILDRFLLPALSDRVEIRNVSQPMILLF
ERQLRLGDILTAETLIILAVLAGAFVLVPVVLIRHFKAIERAEVEHERSAYLATHDVLTQ
LPNRYLFADRFDQAFSDWKVNGVPFAVLLIDLDHFKDINDKYGHEVGDQVLRAVANRMLQ
ATRSCDTIARYGGDEFVILVTGITHTESAELKAARVLETIAQTVVTSAGELSISCSIGVS
LCPTHGKSLDTLLKAADQAMYGVKQLGRKGVAMTESPEA
>A0A8G1MDI9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MSDETQRWKEKYLKSIEQQEKLERRWDARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRE
VVRTDDMDAGLAALLPRLEKAVLDSEQRRETRVNQTSAALTALVTQLQTLPLPREVSRTL
KNFAKQLDGRVSQAREIPLLLSELSGLQGKALRQLDNPAEPDRPGFLQRLFGNREADEAI
PQATAPAVQTAPLQIVEPIAETPPATVDLAPAVEHPPVEQPTVIDVQPAAAIPESLEVQA
TEPAPELVVFVPPVLQSETASAQAVEPQTQPNIEQPIDPTPAEQEPQAVNPDELTPVTIE
AEHLAPEEVLYALPDSPEPSYSSVAKHIEDTLLGLLDDLTLPERHRPQAEAMRDRLQNGL
NWYELIPILDDLATLMLAITDSGQHEFEAYLQQLNERLESFQSNLQAASDGHADNRSAAR
EMDTQIREQVDGLQSSVQEAADLDDLKHVLENRLEGLLGTMDQHQKQRDEREQEVAARLQ
SLAERVAHMEQEALGYREHLEEQRQKALLDPLTGLPNRAAWSERLEHEVREWQQHGNILL
LAMLDLDHFKRINDNYGHLAGDKVLKIIASVLRKRLRGTDFIARFGGEEFVLLMPDTSPI
NGAQLLDTLRASIEACPFHFKGERVTITISIGFTAFKPGEHSDLVLKRADQALYRAKNAG
RNRVEAG
>A0A1C6CJV7|diguanylate cyclase|EC 2.7.7.65|uncultured Lachnospira sp|TrEMBL
MQERCKIGVVIGNANSPHAVNIMKGIDQASKECDVQIMYFMNVSSPYTAQLYPPDTSIGW
DYQKSAIYDYARYVKADVLIMTYGMMSIFMKSDYGKQYLEYFRNVPCVLINEQTDRPNWT
SIIVDNYNGIYELVEHLVRDHGYHNFAFLAGPPGNTDACQRKRAFLDVMKKYDLPMDESR
IETGDFSECVQKQVNALLDRIPNLQAIVCANDVMALTAYQECEKRGLHIGQDIAVTGFDD
WERIRHVPVPITTIRQDSERSGYMAVYSALELARSGHGKNIVIPAKVCVRESCGCTCKQF
SGFDQIENMGQKFVYEKQRNTVYRQKTWMVPMISRNMLIALQDREKFLKNALTPMSFFGV
KTALLYVFRNPVEYNIEKGWEFPNTIYLVARQDGERVEVFEEYKNEVSLEKCGFSDEGSA
RYQHQPSVFCLQSGSTQYGVLSVEITPEEVDMVYLISIQMANALMAYHTEKKRLSVQRER
ELLLEELRSKNEILNFVSERDELTQIKNRRGFMEQAMEMNRVYKNRKAIILFADMDGLKQ
INDNYGHAAGDIAICACADILKKAAGVNGIAGRLGGDEFALMMIGDKTRAIELMETVQKE
IAMYNAQGKNKFAIDMSVGCQLVLCTDELSIPMVLEKADKIMYEEKKKKGKAR
>A0A853SHF7|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MWTKPVLRMNLRRLIVLVAFASALVSLANTFYASYSVQRQLLIDTTLEANHAYASKLAST
AEDFLQSARQQLAYSAGSLPSRMGDEHWLTDEAQRLRLQTNSFNSVLIVDAQGKVLGVSP
ETLALKNRTLDSAGAVQALRERRPLVTQPYVSSAGNLVVFISHPILGKDGRYLGYVGGSI
YLKQKNILYTMLGQHYYRDGSYLYVVDQSRRLLYHPDPERLGDVAGSNEVIDAIIAQQGG
GNRRMHNSLGVDMLAGYAIMPSTGWGIVAQRPTAMTLAPLNQLMANTVWHSLPIALLSLP
FIWWLASLISRPLVQLAEGARRMDAPGTAEHIAAIRSWYVEAAQIKKALLKGLALLQNKI
GKLKTDVQTDPLTGLSNRRGMAAALDAWQAQARPFSVIAIDIDHFKQVNDQWGHAVGDDV
ILRLAQLMRACSRDADVLCRNGGDEFIMLLPDADLDVAMQVAERLRAKVAAAVIPGAGFV
TVSLGVVSSEQEAGNTDAVLRAADAALYVAKENGRNCVGITEPA
>A0A5C7RTM9|diguanylate cyclase|EC 2.7.7.65|Thiobacillus sp|TrEMBL
MPLSTISTEELPAILSQLDQAIYNHQQWYDAISRTLVCQLPANELDLGNDAHRKCLLGQW
YYNNSPTKIRAHPGFIALGEAHEHMHKQAAHILGMARAGMAITTTDYDNFANSLQRVRLQ
ILTLSRELEDIQRNADPLTRASNRIHMLPKLREQQELVKRGVHRCCIAMMDLDHFKLVND
TRGHIAGDQVLAATAHYIIDHLRPYDRIFRFGGEEFLICMLHTDMKDGQELAERLRQGIA
EMAIDVGSGEPVHVTASFGLTLLESSISVEQSIDRADKAMYAAKSEGRNRVCAWEPSME
>A0A1X6Y870|diguanylate cyclase|EC 2.7.7.65|Roseovarius halotolerans|TrEMBL
MSAIFDTLCPMHARLGAHGHIVHAGPTLQRIHPEGDLRGRRFLELFEMRRPVTGQSMEAL
RAAAGLPLRLRLRQPPGLALKGVLVALGPDSAVGPEGGALVNLSFAIALPDAVRAFDLTR
ADFAATDLAVEMLYLIEAKTMTMEALHKANLRLQGGKTEAEAKAFTDTLTGLGNRRLLDR
VTSRMIAGERDFALMSLDLDFFKAVNDSLGHAAGDHVLRAAAQAMLEETRSDDTVLRFGG
DEFMLILAGMTRRAEVDEFARRLIARLEVPIVYEGETCRISASIGAVLSRDSDAPDIDAM
MAKADAALYAAKQSGRGRHVLYDPKTPPVMQAKATQRRADTSPAGPPP
>A0A518GYZ4|diguanylate cyclase|EC 2.7.7.65|Tautonia plasticadhaerens|TrEMBL
MDDLDSQGGPVHPIAGPIVSRFLAGSCGGVIARLDADGIVLEAGDRLASRMPDPGPVPLA
ELMTGPSARRWRSLIDRLRPGGRPRPIRLRIRGGGPTLRLIGLAHREPDGRLWLLAMPEV
DADALGSARELARELSLLKRHLARSDRMGRLVEKARREARTDPLTGLANRRQGIRWLKQA
AREGRLQPTRSCCCIVVDLDEFKAINDTFGHPEGDRVLRAAARTLGEQIRPVDRIFRFGG
EEFVVLLPETGLDGGRAVADRLRVALSGRPLGPLDGSLTASFGVACLRAGESAASLFKRA
DLALVRAKNLGRDRVEVEP
>A0A378Y1U6|diguanylate cyclase|EC 2.7.7.65|Paenibacillus polymyxa|TrEMBL
MSEFSTTDQQTLDSKTVQASGAPLFDDKGYTSFAWLQNMDMTPYDYPYINQLLVQGYRNW
LQQSNGISWISEEYTAVFNFTGVRVAGREEDDDEDLELVERCCISREMEVSQRKLRDGSL
AFVYMVPILCRNYKREPFAALRFTRPAQHSVSNQDALLVASLHFRSCFYSKFEYIFMEDI
LGMQNRSEREGRRRSILFQIVKRMHDKIDVEGVLDEVFGSIAYLFPHVDITLYMSQDRHS
RNPQVKPLLLHERDEDVCVRAFMKGQMAVNEPAGPQDEITEIGIPLRGKQGVYGVFHMIL
PAGADSMEKVDVELIAMMADTAGTAFENAKLLEQSNVLIHELRLINELVQRLNQSLKLNE
IFEFAVQELLKMFMADFCCIVQLDQDGSCFRVMSSNVESLKLESYPREGGFAGLICKTGE
PVIVSDYRKDGKISSWFMDATDSQSLMAVPMKNRGTPRGVILLSSKLPHFFSYDNYKMLQ
MLAPHIGLAVTNAMLHAEVRRLANMDMLTGLYVRHYVDRIIQEHQEKDFCGSLILVDIDQ
FKQVNDTYGHQTGDEILKSVSNIVRSATRDEDVCARWGGEELAIYLPQLGVQQALGYAEK
IRSRVQYETNPQVTVSCGIAEWNWLDEQISIESLFYRADMALYEAKNEGRNRIVIDHIGD
V
>A0A0P1FC69|diguanylate cyclase|EC 2.7.7.65|Thalassobius gelatinovorus|TrEMBL
MPTTCEIHLAQLLDTLVPMHLQLDTDGLITHVGPTLAKLRPGVALGGMSVFDLFDIQRPS
NIGTMAALRTQAGAKLHLRFRSPPCTALKGVLSPFGDRVILNLSFGISVQDGIRDYALTA
SDFAPTDMTVEMLYLFEAKSAAMDASRRLNARLQGAKIAAEEQAFTDTLTGLKNRRAMDH
VLARLTESRAAFALLHLDLDFFKQINDTMGHAAGDRVLQKVARIMVELTRQQDTVVRYGG
DEFVLILAGPTDKQVLQSVAERLIARLEQPILIDGQPCAVSASIGIVRSVDYDRPDPIQM
LSDADAALYVSKRGGRAQLHFHGAE
>A0A378Y4Z4|diguanylate cyclase|EC 2.7.7.65|Paenibacillus polymyxa|TrEMBL
MLKELINNFALLTSFLFFGNLFSRKYERYLKNHALIHRVMNGLMLGLFGILLMMTGLWIR
GHFVVDLRQLAIIISVYMGGSVSGLLTTLIISLYRIYITGGWTDISLTATVNCFMTLVVS
LIFIREKRLTLSKWMSAVLGAVVVSLLSTFFVANPPNSETIIIITTVKMLGGLFTYFMMS
HIRKTERAIHLLEEAANRDHLTGLYSPRAFDALFEEVLHASKTTKKPFGLVMLDIDHFKK
INDTYGHLNGDTVLSQLGILLNRESTTRAYPSRKGGEEFAILLGDCDTEKAASFAEKIRK
AVENECFLLNDGTIISLTVSIGAGSSPVIASRHLLEKADEALYEAKRSGRNRVKLAKP
>A0A2X2YUC9|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MAFPLPVTQPVWHNGKIIGEVCLTARDSLIGHFIWLSLAVLTGCILLASGIALMLTRYLH
NGVVDALQNITDVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRNSITELMNDSSARSCSALLFLDGDNFKFINDTWGHAAG
DRVLIEVARRLAEFGGNHHQPYRLGGDEFAMVLYNVHSEYEVKRICSALSQEFNRPFDLH
NGHLASMTLSIGFALTWEHASAEKLQELADRNMYQAKHQRSERSI
>A0A6A9JYJ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRLPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHGLSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYADDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKATLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A1V5C4U6|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdaceae bacterium PtaU1.Bin034|TrEMBL
MKPSLDRCFSGQEVRDETWINFPVLGRRYCEIQYLPYAVEGGSFDRAVVIISDMTERKEA
ERQLKAYQEHLEKLVEERTEELRKSEEKYRNIFENAVEGMFQTTPDGGFLNANPALASMY
GFDNPQQLIESISDVRTQLYLYPETRNELMAIIERHGLARNFEHQTRAKDGTIKWASLNC
QIVRDKSGKILYYEGTIQDITERKQAEQALREAEEKYRNIFLNATEGIFQVTPDGRPLSL
NPAFARIHGYDSPEDLMSHITNIKEIHVDLDRRDEFIKLLETQGYVYNFEFRMYRKDGSI
IWISVNARVVRDENGKMLHRQGTVQDITERKRLQEQIFLQRDLALELARTSSLDKALPLC
LETAIKMSGMECGGVWLKNPTGDLELVSSVGISEDVARKLSRVPEGSGGWTLTMEGKSIF
MRPTKELTPTSFAEGYKYIAIIPIILNHEVTGSFNILSKVLEEMPQQDRIALDLLAAELG
NIIARLNDQQQLQEEVKRRREAEKALEAERLNLQETNTALKVLLKHREEDKKELEERFVS
NVKQLVLPYIEKLKKTRLEDIQRTEVDFLETNLNEIVSPFLNNIRAFNFTPRQIEIIALI
KEGRTTKEIADLLHVGKGAIDLQRFLIRKRLGLNKDKTNLRSYLLSLA
>A0A2D1QKI4|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLIRTLPSGKLLEVNSSFLKSCGYTREDILNINYRKLIPKKYEDQVIAQIEELNRIGRFG
PIDKELIRKDGTCYPVRVSGIILSEVDGRNILWGIIEDISDQKHAAVINYNFTFYDMLTK
LPNRNLFTERLNQVIAANKRSARHAALIFIDVDNVKSLNDEYGKSAGDLLLLEVSSRLKN
SVRETDTVARFGGAEFVVLARWLSTDKAEATNQAGLIARKLLAALSAPYKFDLGCDSQPD
ILIEHHCTASIGVAVFNADERDPYDFIEWADSAIYKVEETGGNSILFHDTSD
>A0A485FJ12|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MVFRFGGEEFLVLLSSTPLQAACMVGERLRQAVEELDYRHAGEPLKLSISLGCADLRPGE
GSDDLLRRVDEALYEAKRDGRNRLRCA
>A0A1V6GSS2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MRAILIVQESADPRISELVGSLFDSFKVITGKQDVIPMIYMEPPDIILVEGRFLVTRGSG
IVQEFRSNTIFGNVPIVAILERRDIEASSWQDVAIDDYLTLDETDSAITRRLEFISRRAV
RDMDMNPLTRLPGNESTIRTIQALFDAREEAAIAWVDIDNFKPFNDRYGFSRGDEVLAAT
GRIVTNAVRELREEKTFVGHIGGDDFVFICPAGHVRGLCEEVISRFDMVIRNFYNDDDLE
RGVIASTKRDGSEKTFPVMTVTIAVVLNEGGRYTHYGQASQDATEIKKYLKARDGSTYMI
DRRALKT
>A0A1Q2YZS1|diguanylate cyclase|EC 2.7.7.65|Roseomonas sp. TAS13|TrEMBL
MLPHLMPLSEEDRLAALRSYDVLDTACEASFDNIARLAADLTESPISMVSLVDAERAWFK
AHHGLEAPEAPREHAFCAHAILEPGTPLVIPDASRDPRFAGNPLVTGAPDIRFYAGVPLV
NPEGAVLGTLCVLDRKPRRMSAERQRILVRLAEAVMTTLELRRAMNRVHRLSMTDALTGL
LNRPALMDALDKAVARLNRHGEGFALLYLDLDGFKQVNDREGHATGDEVLRELAAVLWDN
LRREDMAARLGGDEFAVLLTGREPDAAIVAERLQRMLEAAMRAKGWAVTASIGAVSFHNA
PESVDAALSLADSLMYGAKAAGRNRVLHRDH
>A0A1T4ZBF4|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MNSSLLSEAELRAIFAAMSDLVLTLDHQGRYLNVITNQPKLLYKPVDEILGKTLHEVFPQ
PLADYILETIQTVLQTQGTILLEYCLEIEEKNIWFSANLSPLSDHSVVAVIRDIGEHKQV
EETLQKTNLALAEAQKLAHLGSWSYDLVTQQIYWSEEAFSIHGLSSDQPVPSYEELLQIF
THPDDREIIRHRIEKAINTGEKFDQEIRIFHPDGSLHYILIKCQGIINQQGQVIELFGTF
LEITERKQIEETLRQLLKRERVITEITQRIRQSLNLKEILNTTVIEIRKLLQTDRVLIYQ
FESPQDATVIVQSVGAEWISLWGNKIPSTYLTQEQCVIPFSQGCLHNISDVYTINCKPEY
LQWFEQYQVRACLGVPIIKGEILWGFLMVHHCACPRQWAYWELDLLEQIAAQVSIAIHQS
QLYEQTQAQAQWERGLRRVIQAISQSLDLTTIFSTATFEIGQLLGVDRVSIAQYLPDQNH
WCVVASTTQNPEIPNIVEMIIPDNNNLILAELKKQKVIRISNFKQDVIRPLNQDLAEKNP
GALLIVPLLVGFSIWGSLSLYRHHQTWIWQDTEVELACTLVEQLQVAIQQSQLYQQLQVA
NQRLQGLVMMDGLTQVANRRRFDEYLLQEWKRATREQQPLALILCDVDYFKQYNDTYGHL
AGDECLIKVAQALDETVRRPGDLVARYGGEEFAIILPQTSATGAVQVADLIIQTLESLKI
PHRTSLISSNLTVSMGIASLIPSLDSSFQVVIEVTDQALYQAKREGRNRYIVHNGE
>A0A1V4SYP2|diguanylate cyclase|EC 2.7.7.65|Clostridium thermobutyricum DSM 4928|TrEMBL
MRIVNKIYEIKNNIKNFNAISEYKVLDKSKDREFKLTILSDNAIDKSKIRYISNNFKSIK
NFNFEGIYETYELISIKEIDGIRLEKIKHGFISEISKNEVDIKEYLRIVDEEKILLVIFD
ILSIVNTLMLKGFIYSNLMLDDIKINCEDGVGTVKLPNIITSEFGKLDGIILSCDNIENL
GKKDIDNDRRNLDYLIKIIQEIIEVSVQDKFYKLKEIDIILKNINKNKVQDINTLIEYLN
RKIFSKNKKFIMKNIQKIEEHIDIVGRDIELDNILKTYCDIAKGKSSSKAILLDGGMGVG
KTRLLKEVKSRLEYTYITNIFSIFKIKNEVKLRWNNCAKEYNYSNGFRLELKKFTDDFSE
KIKKRYNLSFTEDVKEMYKIINSGLKIIDEHSRIAPMVLIIDDLDKRNKICRMFFKHLIE
NLSTLENILIIASLDRSLEDEEFKEYYEEILYNQNVKEYKIEMLNKYYTCEMTRKVLNTS
NDITEIVEVIHNDTLGNPSLIMKKIKDMYLYKSIYVSKNGIWKYRYVYMIFNSVSYLEEK
YIDKIEKLSFFEYSVLKKLAVYNFTIREDIFLKKSIVTLKEKEAYAELKIKNVLIESYDD
NGINVDFKDCFYKKIIYKKMNRRDKFSEHLNFIKILKEICDKEDRVYNELIYHLEMGKEY
DQMIIYAKKYANKMNKIGENEKTISIYKRILNYLGDGEMLEISYEIGNIYARTESDSKAL
GYYKKANEKAIALRNYSYIIETSLNIARIHIENENYTEAFENINIARINLLKTEYKLGYA
KYFLIKALYLKYAENKEEAIEFANRALNIAKKENYFGLIGEIYLILFSYSIQEGDFILAE
EYVSYCEKVFKEGISGKKYYENLLNRGIIYIERDKDVEKGKQVLIKVLKASRKYKIASLE
YNALIQLANIYAYLDRFEVSKKYLLISLEVIKSGKNLKRYLNSTYEYLIYVSAIQRDISE
LIKYKNILLEIDKTSGTELLYGLYYYALGDYEKLKYKINKLSDENIKSVIDKKPYLKIKT
NFINIMLLKNINNIYEEITYIEQISRKSHNTKAYDNKMISLILLLNDLGYRDLACKVFNK
IKYKISFTKLDEVINLKITNKFKSYSINALINQGLRLINDMKNDMNKVELYYIIGENYEK
NNCYSLAFENYYEGLSILSSYIRKEKSEDKIKIVSSKMFCKIFEKIIVCANEKLNLNLDI
TTMINDNEDIDKLLNEIKVSNMMKNNKFKKIMIEKYEKSYLNKIQDAESVLVNFKENIIY
NIETIMKFIIRETLSTSAVLIMKNGRKNEVIYSYRTTYENIKDRLLSKKINVDFFVVDNE
EMIQNEVYNEIFQNKTKACFYKKLSSKYTEEKINNSVDIELILMSDKIINDINYESYEKI
KRYENVIIFLLEQYKLNISSTRDKLTGAYNRRYFEKTMNNIIMNYNYTENIFSLIIVDID
NFKGVNDKFGHQTGDIVLEKISSIVLEEIENKDIFSRYGGEEFVIICPGKNSEEAYEKAD
NIRKKIQEADILRGRREVTVSMGISEYPKHSKKKEELISKADQALYKAKRGTKNIVKIWD
ETFDIKIEGSDILAGIMTGNTSKDYERISSIVKIIEIIKKDIRNEFKLYDILTKILKLTE
SRECMLFKTNNNNEIICEMSIRERERGWKNIKYFNRKLIDNVFKEGNGLYDIDWDEVVNE
NKTMPKWNSICIVPIINEDEVKGAIYMSVPLKRKEFDFKDYNYVNTIGNILSILF
>A0A7W6J8F6|diguanylate cyclase|EC 2.7.7.65|Gellertiella hungarica|TrEMBL
MTARILVVDDIPANVKVLEARLIAEYFEVLTANDGFQALSICDRTQVDLILLDIMMPGMD
GFEVCERLKANPRTTHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLVSRVKSLL
RLKTLSDELRIRAGSDHPMDELARLGEGRVEEAAQVLLVDPRASSQERIIKALKPVAEVT
AMPDPQADVFEAADNVFDLVIVNGNLDGYDPLRLCSQLRSLERTRFIPLLIIAEQGEENL
IIRALDLGVNDYIVRPLDPNELVARCVTQIRRKRYSDRLRNSMKKSFELAVTDPLTRLSN
RRHLDNHLKMLFNRAAARGRPLSVCITDIDRFKAVNDTYGHDAGDEVLKEFASRIRASVR
GADLACRYGGEEFVVIMPDTLPDAATAIAERLRTAIEGRPFSLGTGQPAINLTASMGIAS
NLAGAETPEQLLKQADQALYTAKHNGRNRVVATAA
>A0A443IIS2|diguanylate cyclase|EC 2.7.7.65|[Pantoea] beijingensis|TrEMBL
MKVNASFHFLGSKVKPKNLVHFCFLAVFCLSTFITWREAIALKNTYEVNQRIKLDSVSTA
LESQIQFTLGGLDFFRTMFDYALKSPSETFDTRHISDIFSRLRARPIWRMNVDSGHNMTL
NGVSDTWIKSWPILNRDDEQRLQDELNAALKFSYILQFSDPEHDFQSRLWYIARAGFYVS
STPPRNDAEVLESYQRMIQSDYFTSMSPENNPSRRRHWTPLYHSLQNEGRMITVSVPVDR
NGYWYGVLAMDFSSQRLHEHLQRAIPQQYDGMVAIFDQKMNEVATSGNAPQARNYRLSAE
EMRKLSQAIQHKDEGGLRVGTRFITWNKMRSINGVAVSIQNLRDGMHGESGRVTLVLAGM
WGLFSLVLLASHQTMIRLVTHMGQLHVKLAWRANYDGLTQLYNRTAFFDHSEQLAERCQC
SAQPLSLLQLDIDYFKAVNDRFGHQAGDRALSHVATVITHALRKTDIAGRVGGEEFCVLL
PDTSLKDAVAIAERIRQTLAGDRIQVTSDTQQRVTVSIGVAGSEEQGQYQVDSLQFIADS
RLYHAKQNGRNRIDWQS
>A0A7H4P3A3|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MSPLSIRSFTLFREEQPVRDALVLFTLTLLLHFFGAMLRLVQELSFFWPLNAVMAGIFAR
YIWLNRSYFYAICFAAMLVYDGLTSRWGMGLASFLINFSNIVFIVTLAQLILWDKRRADS
MPGPINALSLFCYCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSAFGRFRLRQLLPAIALVLSIVLGVAVGGAGSITFPLPALIWCAIRYPLPLTCLL
TFITGISEILLVANSLIHLTPDTRMQPWQLFSTRLGIAAMLISPIIVASSVEAINNLVKQ
LALRADFDFQTRVYSRSGLSEALKRQPLSEDKRLTVMVLDIDGFKQVNDRWGHECGDCVL
AQFAQQVRLLVGEEGMVARIGGEEFAVAALTSSERDGQVLAEKIRQGIESQTFTWGQYKI
QLTVSMGLESQPLATARVTDLFNQLLMEADDSMIRAKRAGRNRIFYARNGLNNPIRKRDD
NFACVKYKLKT
>A0A2M9MKA9|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM2FR|TrEMBL
MTNILFTNFCIFVTFLYLSGLLSKKYVAGVVTPSIHVKINAGLLFGIYGIILMYYSFPID
PRFFADLRHLAIVVIASYLGWLPSLIAGVLIALGRLILFGMSTSSAIAGAGMLLIGIICG
MLSRMHWERLGKMLLMSMSSMLVLLCIMWMNIPDHHKVYTVFTQHLIISMLATVVIYMLT
EYINTSNQLFLQMKKNAETDYLTSLHNLRQFEQLLSERFLEAQHFSERLGVLVVDIDHFK
KINDTYGHAAGDAVLQQLSKVLREHSRSFDEVSRNGGEEFSVLVPEATIDETAAIAERIR
AAVADHIFVLEDGTKIQITVSIGAAVHPDTIRSKNAKELLQQADRELYRAKDSGRNRVCS
APEIHDLILS
>A0A729KYB8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kouka|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8B6KVI6|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MVVTDLDALNILSTPIWVVLPKNQEILFANKEARKIAGDIQLSRMRNGRFSAHAQQHLHA
YLPALAVDDHVIEIWTIQTEENAFPLSCRLSLTQLEPYGVVIIFEGLYISESVVTQPASS
KLMAKAYSRSEQSFYEQFFSTNTAPMLLIDPSKEGLIVDANQAATRFYGYSRDEMCRKHT
WEINSMGKDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEYAALKDPLTDLGNRRQFFPLVEHAHAQSQRYGQNFSLILLDVDHFK
NINDQLGHHKGDEVLIFLARTLESIIRECDIVFRWGGEEFTILLPSTNLKGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A7H4PAN7|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MDKLLKERNTLNDLSMLDPLTGLYNRRGLQNRLDTVLSLDSAGHYVLLLDIDHFKAYNDH
YGHMMGRPGINSGFRRHS
>A0A5C5VFZ0|diguanylate cyclase|EC 2.7.7.65|Posidoniimonas corsicana|TrEMBL
MTPAAPRTFALEGWLDRCKDHAALSIAASLLLATIVAAADYATGDEIPLIVCYLPSVLIM
TWVSSAAVGATLAAACCTAWLADDLLALDGQGVTAQEAWTAAIHAVFFVVLVGMLTRLRI
ANENERRLARTDGLTGLLNAKAFRERAEEELARSVRREHCVSVAFIDCDNFKTVNDTLGH
LEGDRLLAAIAAEMQESVRKMDVPARMGGDEFAVLLPETTEQQAEQVIARMRERLDAAMA
ANNWPVTFSIGVAVYETPPRSVDELIHGADELMYEVKADQKDAVVFRLVA
>A0A3S4VSE5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MRDTYGPREPVPETWPRVRRVTHYDQQVRLIRQWWGQPDHYHWLSGYLVSRHARGFTRKM
MGLIVVVLGAVPALMLLSPAGPNTRAGQAVSVVVVVLCAVMASVWFTRWPSGRQSLTFAI
LSDISIAAVTLAWPDPLTGLLGCLAFAALAGYVAFFHSGRYLLMVLLTAAGVAITCTVQI
ARGGDAYLATVAFLMIGVGVLAVPFSAQVLVHLLGIDASQSHTDALTGLRNRRGFYRSVR
ELISASPGRGHSYLSVAMIDLDRFKVINDTHGHATGDRLLAAVGASLRQATRSDAVVARI
GGEEFLIAEATGHDDADALAERLRLAIASTAWDITASVGVACRRFDVRSDTRELLTELVE
AADIAMYDAKRSGGNQVRRAGEPAV
>A0A448IJ25|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MATQLSFVDGLRHWWQQSDHYDWFADYLQARGLQTMARMVTATAALTLAAVCVTVMLSAA
GPSGSLNRALGWASIALMAGCAAARFAVWPTKRQSVILILTLNLAIAVFCQVQTTPLIGV
VGATAFALTGVSIACFHSAKYMLYNVVVACYIGVAQSLHDLADADPALILAALGLVLLVN
ISVPFGVQSLVHALGGDVVQSDRDPLTGLLHRRALFQQIEAMLRSNRGARYLAMTTVDLD
GFKALNDTYGHSAGDEALLAVAKALVTTVQDQALVGRVGGDEFLVAELADTPEASDLPAQ
LREMIAELPYAVTASVGTAVGTIRAVPLEHSYELVVTLVRLSDRAMYVAKRKGGNQIRHT
VIDFAESPT
>A0A5C5V517|diguanylate cyclase|EC 2.7.7.65|Posidoniimonas corsicana|TrEMBL
MSTTILITGLALGALQLIAGVAIGRWTATPRRALRAAGEDRRRARRLAGELQTLTADLSA
QARAQGEQLSRVDERLQSEAASLDADSAEHPLTSLVSGVVREMLRANQSLQERLASAELE
LEARTAEVAEHLQTAMTDPLTGLPNRRALDDHLNVRADAWRKHQTPFSVVMVDVDHFKQF
NDTHGHAAGDQALRSIGAALRGALRHHDVVARYGGEEFAVVLPHTDLSTAHAAVRKTIDA
VRSTVVEVHGETIPVTASVGLASVRPSERLESLMRRADQALYAAKQAGRDRAWLHDGHDL
SPLEHRVGSTESPPGPGGGLRGISPDLQQACSALSSSMTALLEPETGTHAP
>A0A174Q530|diguanylate cyclase|EC 2.7.7.65|Fusicatenibacter saccharivorans|TrEMBL
MSLSDKDYQKKLDVQIAYWDKLKNEIQKVRSGENGTADLVDMSETYFQMADETVATVKVS
HANRQLEQKAYIDLHTGLPNKSKCEELFHNVEFIKTPTACIVFDMNNLKRVNDSLGHSIG
DQLILNFARLLRNSIPAKHFVGRYGGDEFMAVIYDATRESITEILTELQNEVEQFNGYGT
QFRISYSHRLALSTDYNECTLRTLFDKADKYMYENKQQSKQGRQD
>S0G246|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MIWTKYQDPTQLVQYLNHHAQILFLIMDNTGIIQHANRFADHYIGGPVTGKPFQRLIRDF
HQTFQLDQAATCPDTVHLLEFDTPSGLSQTCRFHFYASSGHILALGQLDVEEISTLSDEL
VALNQELNNLTRQLNVKNRELTKANKTILELTRIDPLTGLANRRFFSERIQEMISLALRR
SQPLSLIMTDIDHFKRVNDTWGHDAGDRVLKAYADLMKTRTRAEDLVARFGGEEFIILMP
LADVHEAFAYAERIRCAIAKADLLESGDPVTASFGVAGLVFDETGDDIIKRADTALYQAK
ASGRNRIVIASEPPLKNESDSL
>A0A1C7DA27|diguanylate cyclase|EC 2.7.7.65|Paraurantiacibacter namhicola|TrEMBL
MRSDGIAFVWPASGVAAGGLLMTAVQWRKTLLGGIFVASVLVNLNAGSSLAVTLWFSLAN
IVEAYLVCRIASGRDGASGSLNLPRWVARLALGAVAGSIASGTIASLAKIGSGQALEFFL
SWTSTVLLGLLVVTPLVLAAGDRKMRRVAQITDGRVLLRSALFLATIAVSVAAFAQQSAP
LLYLPLAMAMLMTYFLGPFGAASAVFIAALLGSLFTAKGMGSVHLVEGGPQTRALYFQVY
LLVMLASTMPVATLLARSRAAARELRRNNAFLSAAEAKAHVGHWRLQLEPESLYWSDEVF
AIHGMEKGRSPDLALALEAYHPADRERVSSSIKGSLASREPFSFEARIQRPDGTIRHVES
TGEPELENGEVVAMFGVILDITERWQVLEELRRARNLARKQAREATKLADTDQLTGIASR
RKFMERLSEEIARAEEGGGKLSLIMFDVDHFKAFNDSHGHAFGDLVLRMVAREAADSTRG
QDLIGRIGGEEFAIIMPGAGMDTGTLAAERIRQRVANLRIEDDSGVAQNVSISLGIGEWT
PGADEVWLMQAADNALYEAKRAGRNCLRQAA
>A0A7Z7LGR5|diguanylate cyclase|EC 2.7.7.65|Mesotoga infera|TrEMBL
MSIHSGKLISSIEKISSLPILEGEEINVAMEILSLAGRSISADCLYFYRTGYIEKGEKTD
FPLVEWISPSISEICSSLRKTHEYTEEDIETLSRLEKGEIVFSQLGSRVSIPVMKDRFYG
VICCEDYSENRIWSDDEIAFLRIVGHSVASLFIFHSLTSAEDSKDLQLLKDTEYQLILRD
SVIGTINEISMLSLKAKTLEEAAGIIIAEISGKPGVYRCRLSISRKINNNIDVSSDESFG
IPSSVGQIEDQTIEVDGPGYLLSRYLKNGAAYRKLCISMELDSDSTGTLEVIFDGSGKLD
GSISCLLGLVGNFLKLALNRVKYLSENERSRKISESLRRSTEIITKSLRMERTIKIIVKE
LSKVIPFYSASLQLLDGNELVVVGGKWPNQLDFTGRHFKIEEGSPGYDVLYRSKAILSTQ
AQKDYPQFNIPDFRFIKSWMGVPLIIKEKPIGIIAVDSDRENAFDCLHLEALKAFADIAS
IGINNSRLHEEVEQQAIRDYLTGIYNRRGLFELGESELKKAQRYHTDTGLIMFDIDNFKK
LNDKYGHLAGDFVLKAATKICGSELRSADIFARYGGDEFVVILPMTDLARTREAAKRLCN
ALCSNTLEYNETTFNICASFGVTSYQREDTLEGMIKRADRSLYISKNAGGNRVSEGESSD
>A0A0E2L4R0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain UMEA 3162-1)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A446C863|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MFRIDLRRLILWISLLSIILVLAGGLHASSLVQRDLLLRNALEVNRVYASKLASASDSFL
TDLQRYLAYSADMLSDMESHPEHMSAETRRQERQLGHFNSSFVVSPQGKVLAEPTSSPQL
LGQNLRSKAFRNALTARQPTISEPFQTRSGLWLILYTHPIFSRDQRYLGYIAGTLYLHGD
NVLDRLLGEHFYRDDSALYVVDRNGTLIYHPDDGRLGQASPDNEAFASARRGETGEMRYT
DGQGRDMLAGYAPVPSTGWSIIAQRPVDTTLQPLNALLMATASNTLPLLLLSVAFIWLLS
RWIARPLGELASIAKHMQNPDSADRIRNVRSWYFEAAQLKRALLMGLASLHHKIRDLRRE
TTTDTLTGLLNRRGLDEALALLQAEDEPVAIVAIDIDHFKTINDRYGHAAGDRALQMLAM
LMSEGSRSGDTLARAGGEEFVMLLPGAPMAAAIAIVERLRLRMASQHGVAPAPITISAGV
AAYPEHGATLDAVYQRADQALYYAKNHGRNVVCVADDNTQAGSRLAPPA
>A0A2X2JFZ7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEACGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAIDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A8H9E085|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEAQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A2T0BFV0|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MVDLKWVEHKNTFKIFLISIWWILVTIAVVNIEDNMWKEILAYSFVVSIVFASYHGKVPG
LIFSIMSSVVSGSQAMDEFLLFSPFAQRILFQILFINVVALVTTSLSEREKKARVSLQQL
FSNMPIGLFRIDSDGKLLKINAAMVHMLSIDEKQKLSSYNLKYFFVNSHEFLELFDNKDT
GVKNSEVMLKKKDGKIIWGNIICRFKETDDVAYTLREYEGSFEDITDRVALFQEVRKLAT
YDSLTGVYNRGYFLAVTEPIFKEALIRRKPLSMLLLDVDYFKKINDTYGHPFGDVVLQKI
AGCIVENANNSNIVGRYGGDEFILFLPEEDYELALKIAKAINDGVKSLDIILEGQKVHVS
VSVGISNLDFNNDKNIDDLVRRADISMYEAKNIDRIMP
>A0A2S8DS61|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MQHETKMENQSWLKKIARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2P9H480|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MRLGGPNEKPVSEAADALAASGAGHGPATLIRELARDLLRQKRIQLDEASRIDRALRDHD
WATVRTYVAKGLARRTEVPSMRENGAGSVPVAAAETADRTMSPEQAADNGVITAGLLRLV
LRLCDALPRLAVNDLGFIEGFDLIRSILAGRLTPERLNEVDARIATLVSQQLEMQQKLQD
ARSSLKDMLSILVDRLGTVGASTAWFQQRVGAYRDVLAGQPEPEVVTRVVVGLLAETKAV
SQEIHRSQHDLAEAHRKVESYELRVRNLEHALAQTARMVQNDPLTHALNRRGLDEVFRIE
ASRSSRYRVPLTLVMIDLDDFKSINDSLGHAAGDRALVHFVTTAQASLRSMELIARTGGE
EFVVVFPATGIAESVDAIRRLQRELARSEFQYEGESRAMTFSGGAAAWRAGESLPQILRR
ADAAMYEAKRAGKNNVVIATE
>A0A7G6K427|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMFIVTVALLVVRDKRLGKNKYEPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPL
LADWFSEQFSTGVLIVPCMLTLAILGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAF
PLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATM
AICPIMVSFSVAALNSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLD
IDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLM
AEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDG
RNRTSTMRYGEEVV
>A0A2S8DSL8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINNREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYKVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGPGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A398Q6A5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLHTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGLMEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2N9M4L9|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MSVRPASVVSTWFGALGLSAWRILPLVLLLSLAGVAQGAGEIDGALARIEQLAGRQPVEA
QRELDAFLKRWADLDEPSRVRVELIRVLIADAQYRSDDVLAISDRIRDRAKALDDARIRT
LLEHARAGAFYELGRSDDGWAALQEELHQAERTRDDDLFAQVMVDRARYLIRRSDFEPAA
EALTDAERRVHGAQAGAEVAFSSANLARAIGDWTLALSSYQAAYAKFAAVGDRTGEADSL
AGSGEALRQLGRFSDAIGPLNVALRLYREVDDKDGEALATQALALVHAGRNDPSLALSLN
AEAIEKLSRLNEPSQLAQARVDRAHLLILRNRAGEALPLIEQAGPVIREKGDLQSQAFFH
QTAAAMLAALGRFREAYEEMEQFLDTDHRRIDQLVSHQLAAQRGRLESERLSRENSLLRT
EASGGQLALAQATRAARLQNIVLALVAIVVVGALYAVWRMRGLMRRIARMAETDALTGVL
SRRHVLELGQRMMNRCRRDGRSCAMLMLDVDRFKDINDRYGHVAGDRALRAISIALARCL
RPEDQIGRYGGEEFAVILPGADAKEAGTVAERLRTAVQTLKPDWAPGADPLTVSGGIAIA
TDEIADFTELLVRADQALYRAKDAGRNQMVYHQGEAMLATG
>A0A518AGG6|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGAYMNWPLGIAPLLLLAPPTVLAAVSSPRVCYW
TITVISVSSCFAEIFFRPDLEEVRSTYPLSIMSAAVLIGLVMLIDLYMGKLRRKLSQLHQ
QNDELVRQLYETQKQSIADASKSTIAELKEKQTSESKDNTSAESGVNYPLLLLTLQDIGR
RISTNQSNESLIPTVISTAKASLQCESCQIYLWDTKSRTLKNALPARARDQLDYRPAANH
GVAAWAIEHRQIVMRNDADQDYRLKRIIEEDAQMPDAIAPLTVGSELIGLLIIDKIDVES
PTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLYNHATFQEKLHELVKNAEAQS
TNLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPENAVLARYGGEEFIGVLLD
HEYSQARQIAEDLRETLENCPILFEGQQLQVTASFGVTEYRHPATNTKDLVRAADEYLYK
AKEGGRNQVVGLDSNTTRKPGTQAS
>A0A331XGM5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHFNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGVLFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A8B2UQ56|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. 9-2|TrEMBL
MDKDFTSTPRPTFKRTLRRINMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLATLGKQGQFAVAEVVNAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPEPISQPIMHNGVMIGEIRLTARDNLISHFIWMSFAVLTGCILFATVVALTITRSL
HHGMVTALQNITDVVHDVRTNRNFSRRVRDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDISAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRYQSYRLGGDEFAMVLYGVHSELEVQHISAALSQQFIRPFDL
HNGHTASMSLSIGYALAWENTSVEALLEHADRNMYLVKNQRSKTIS
>A0A486N3C6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLYIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A2X1QFG2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRDNEISRLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLL
HIKSCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYP
VQLPDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRG
FLTLAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESD
ILARQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASH
PSLNALVATADRLMYQAKQKQGRERR
>A0A5C6EC14|diguanylate cyclase|EC 2.7.7.65|Rubripirellula tenax|TrEMBL
MTNTIPTNMPANSDCTVVMVESSRDFSLNSGSQSTPSRVGNLLAGLRESVAAAEFGAADS
SDLPFENRLAVVRLGMATSLFYSLRTKHAPTAAHCLRVALSCSAWAQRLGLDEDTRDRIE
VAALLHDLGKIGIPDRILRKPGKLSVDEQLTMELIPELGCEILRGCTGDHELLDIIRYAN
TWYDSRRHGDGPRGSALPIGSRMLAIADAFDAMTTDTVYRPAMSRERAIQELNQHASTQF
DPELVGEFSRMLEERPEMLHRIVVDRWLRQLQDNAAPSIWGTVAESPASRKSASSVVHKR
EVLFFQQMFANQKDGVAFTDGEGTITHWNASMQRLTAIAADAIVGQRFSNDSLRLRDEDL
VRDEDACLIRDCLAQGSAIVRSMMIEQPGKTPTPVQVHVSPVAGSVPGVYGTVVTVRDLS
DQATLQERLEALHHQTTQDPLTGVANRAHFDNQLEDLTEATIAGGPSFSLIICDIDHFKR
VNDVHGHPAGDEALKSFAAVLRAHSRDGDTVARYGGEEFLLLAPNCDNATASKRAEAIRI
ALESTPLPSLGGEAVTASFGVTEFQSGDTAETVLARSDRALLKAKDNGRNRVIQLGAGNV
MQSPADETVATRGWLEWLTGSGPIENGEFDIVSPVPVDLVIEKLRGFIADHNAEIISVDE
NQVSIKMNATYSRGGRRRADQQMALRVQLTLSESREERSTGRSFNRTNVHAQLQPIRNRD
RRGQDVAACFSQVINSLRSYLMGELMRPDSA
>A0A332W6J7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFDISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVI
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A485XX50|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQLRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A377V365|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MYPQKTWKSPCVAGQFEGEGWRYRKDGSRFWAHVMIDTIRDEQNTLLGFAKITRDISEQK
AINDRIAWMARYDALTGLPNRVEFFERVEKLITGNDARRFAIFTIDLDKFKEINDLQAI
>A0A5E4VNR1|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MALLLDAVFLVDKAGALVYVSPACESILGYSPQELLGRSMIDFVAKEDRERTIEESKFVM
AGLPRIGFENRYIHKDGHYVHIMWSARWSEDHGLRIGVARDVSAKKQAEALQRATYSISE
AAHDAADVRSLCKAVHDTLSTLFPIDAIVVATCDAELAAWEKAYQYRDSGDVPVLDWRQA
QHLSTQATQAKRPFWHRIEAVPVDGAGQSVPHVRAEPLVPGAPVETGTQVLAVLPMHTAR
RAVGTLMLYGPASALRAEAAQRLLAFVCDQTALAIERKQLIDDLYQAARFDELTGLPNRR
TFGEFAREAVRRAQRTNGKLAFLFADIDGFKGVNDSLGHAVGDLLLKEIGQRMKTGVTGC
GFVARHSGDEFVAIVQDAEVVERIDVAVTRLRAEIEQVISVNDASLSVRVSVGVAVFPDD
GESMSELIRVADRRMYANKSERKSGGASFLQRLI
>A0A377ZQP7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MVQRDGKVVLHSDPGALFKPFVRDELMDKMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIF
RVDNATLVNLTRHETNLVIGGFTLAAIIIILFGLYLRHASRTVLMNIINAIKTGDVKRAP
RLEAMLSKAIETNKQRELSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDID
NFKSINDTWGHLNGDIVLRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLL
ETWRVNVERRTWREDGLTVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A377W7Y4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAEALGLALANQRLRSALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMID
IDHFKTINDRYGHEAGDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQC
ASEIYTQVRNMTLRDGLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRI
VSFVRLKTS
>A0A377W3V8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAVRAEGDLVARYGGEEFVVVLPGVSLAHATAIAERIQQKIREAGLPHAASAVASEVTVS
IGIVASDGTVPIETLIARADSALYQAKNKGRNQWSY
>A0A4U9VMP4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIR
LMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDH
FKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEG
IRQAVSEYQTLSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNRVSRMPFENVEL
LHSRGGAA
>A0A483NGD2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STMPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A486RXL2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTKGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRT
>A0A862ZG44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2N9M5I7|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MVRFDRINSLLFGAALFISAVPWVEAASPAALTKVADIHGLTNKQASQHLPVSFEANVTY
FRWFDQDLFVQDGDAAVYVHATTSLRLVPGDRVLVRGTTRESFRPFVESADITRVDHGAL
PTPKHPTFEQMIRGETDCQYVTVRAIIRSADTTPDPRSPVPTIYLKMLVDGAPADANVDS
DNQQAINDLLDAEVEITGTVSGHFDNKMQQTGILFHIQSLDGVRILKRAGSDPWLLPVMP
MDRVITGYKDIDQSQRMRVQGTITYYQPGSALVLQDGSHSLWIGTKSYSPMRIGDRAEAI
GFPDVQNGFLFLIRSEVRDSSIQSSVQPPILTWQDLSRGGNVMRGRALDLVSTDGTVVAE
VRQSTEDEYVLNAGGHLFSAVLRHPDSPGQAPLLPMKEISLGSRVRVTGICMLLSADPFH
GEVPFNILMRSENDIVVLARPSWLNTHNAVLLVTWLIILVLVVGMRGWYLEHKNRRQIGS
LAYVEKRRARILEDMNHSKPLAGILERITELVSVRLNGAPCWCRVADGATLGNRPPQLDS
SLRTVEHVIAARSGAAHGTIFAAFDARTKPGAAEDEALAMAAELATLAIETSRLYSDLVH
RSEFDLLTEVQNRFAMEKTLRSHIHAARQSAGIFGLIYIDLNEFKQVNDVYGHQAGDQYL
QEVTRRLKGQLRPGDTLARLGGDEFAILVSRVRNRPAVEEIAARLERCFDEPFKGDGYEL
RGSASIGIALYPEDANSADSLLRAADAAMYAAKYTRPGRSRGPRVSGG
>A0A862ZKC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKLTGRNRCMFIDEQNVINRV
>D8FTY7|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MNSNLTSVKQLAYRTVFIYAFFSSLWILLSDTVLGSLTQTSGFFTNIQTLKGWVFVLVTS
GLIYALIRRNFHSLQESYNLLEAIIEGTTDAIFVKDIEGRYLMVNSTTAQLLGRPKSEIL
GKDDRNFFSLETASQYQENDRAIFASGETQTIEEFGIINNIKRVYIATKYLCRDKSGKTI
GLIGISRDITEIKQATEVLQKTKEKLQAVVSAAPLAIFVTDRQNYVKMWNPAAEKILGWR
ETEVLNSPLPIIPPQKQEECEVVRDRVFQGDSLVNLEAKAVKRNGSEIDISLSLAPLYDI
DGQINSILSVIADISDRKRAEEERDRLIEELRQQTEDLTALNIVTGNSISTLRLEELLNV
LLERIVTVMKADRAAILLIGEEEAATTLSVRASIGVETGISASTIPIGEGFPGIIAATRK
PLYVEDAQTDGRVCNEYIQDCGIRTMLGLPLKRYDTLVGVLHVDWCSIHPYSDRELHLLE
ITAERCAMAILNAQLYQQTKELQERLQLQIERMPIGYIFTDPESRIQEWNPAAEQIFGFS
KEEVLGRHYDIIVPPEVRSEIGDIFQQLFHSEHTKQNVNENLTKTGEIITCDWQNTTIKK
EDGAVIGVLSMVQNITLQQRAEKQLWKYAFYDQITDLPNQTFFIAWLKQFAVRSLCEETT
LFAVLYLDLSRFQLVKYSMGQKVANELLMAVAERLQTCRPKNDEFEQLPKINSIAHVGPD
EFAILLENIQEESDAIAIAEHIQQQLSAPFKLDGCELFTDSSIGIVLSSINYQQPEQLLQ
AAETAMNQAKGLGKSRYAVFNTSMQERAVRPLHLDADLRRALENREFQVYYQPILSLVNH
QIIGFEALVRWLHPERGLVSPAEFIPLAEESSLIIPLGAWVLCEATSQIMAWQQKFPTNP
PLSISVNVSAVQLVQSCFIERIDRLLKETGINPLSLKLEITETAVMENAKSVTNILEYLK
DRGIHLSIDDFGTGYSSLSYLHTFPFDTLKIDRAFVSRMSIDPKNLEIIRTIIILAHNLG
MDLVAEGIETREQLNQLQQLQCEHGQGYLFSRPVDREAAERLLEMQLSSGGSNS
>Q32H32|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFR
RCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREI
RATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVDD
VWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPT
KQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPY
YGNSASVKLLTPTQDSRDIINAATRSLDAIWQVGHRYQKAGVMLGDFFSQGVAQLNLFDD
NAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRVK
>Q327T5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEA
ILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPA
NPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAR
ELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLP
NKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLVEKLKSVLSPRM
ILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDL
TAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQP
QVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQ
ERGIILPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAIL
RPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLA
QSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A2U3KKD6|diguanylate cyclase|EC 2.7.7.65|Syntrophobacter sp. SbD1|TrEMBL
MINQIEQNLSRTLLHDFPVFLATIAPDGRILLMNDAVLSAIGRTRDEVEGKEYLTGFIPE
SDHDEFARLLGSFGPRPKTVSIETGLVCGNGELRIVEWRGRPGLDDEGYRHVVHCVGNDI
TEIRHSTQELRQTKEYLENVLEYSPDAIGIVDAQGRFIKLNRSAEILYGYSFDELRGKTA
YDLYADRDELAGMLSLLKGQGFVKNYEIDMKKKDGSILPFDVSISLLKDSSNTVLGSITV
ATNLSEIRKTLHSLEAVNNELQQEMQMHQATLEALKKSQNQYRTIFENTGNATIIIEEDT
TISLCNTEFARMSGYSKEEIQGKKSWTEFFSDEFVALMKEYHRLRRIDPHAAPRNYETRF
RNSRGQYKDMFLTVATIPDTKTSVASFLDITERKQAEQELRRSHEELEQRSYEISLLNEM
INLLQVCGSGEESYYVLGNYVQRLFPSDSGSLYLLDQSKTRLEAAFSWGSIAAGGQTFEY
DDCWALRQGKVHLVEEPGGVPCKHLNTTPVAGCLCVPMIAQGEIVGLFHLHCNHSDIEYP
ETHRKILFLKQRLATAIADHIGLGLANLNMREKLRTQSIKDPLTGLFNRRFMEESLDREV
NRAKRHSTALSAILLDVDYFKRFNDTFGHEAGDLLLAELSGLLKDSVRGEDIVCRYGGEE
FLIILSGASGDEAQKRAEQIRNKTRQLKLLHNGKELGQITISLGVAVYGQNCRTVKAILN
SADKALYRAKDQGRDRVVMAHDETEFAETPQPNATQCC
>A0A011NZ42|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MIENDLLQGAVNDGVIQIAGLRSLLMSSGSGIGFGVKTLDGSYRVANPVLERLLHQKPGQ
VLGKSESELLPSAVLATLGPCDQQLLEGAAGTSEEVDLAVDAQPVRYLWLKLPVFDPGGK
LQAIASLVYPYVAEQAPTAVQQTLDHLQQTNQQLQQTLVELEQVASTDKLTGIWNRRRLE
DCVRREMERFQRYKHPLSLLVIDVDFFKTINDRYGHGTGDRVLQLLSTQLQDGLRGADSL
ARWGGEEFVILCPDTNKATATTLAERLRAQVANASFPEIGRLTISIAVAECEADESWAEW
FQRADEALYRAKAEGRNRVHLAPGTGGHLAAEDGRVANFVHLVWRSAYECGNEDIDRGHR
QLFSDANDLLAAILSEHGAESVNATVDKLLTDIRAHFAEEESVFVAAGFPDAAAHIAMHQ
QLIARALSMGDDYRAGKQSLGDVFQFLAHEVIAKHLLGADRKFFDHLQRKVSPAG
>A0A485CG41|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MQIPEGFSVPWNESLCKRAIDDNCQFSNDVNTRWPSCIAAQGMGIITFFSIPVRLADGSL
YGTLCATSRNKQPYNLEGEQVMELFANLISHYIEKETLVDQLRTANVALEMHSYTDELTG
LANRRALFKHLSSMFPPRARTAAQSADDLYRPR
>A0A8D4C0W9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas balearica DSM 6083|TrEMBL
MHITNEELAGEWQRLTAAYAPAAADALRQLAEQESAELARYFYAQMLADPQSAMFLSHDQ
VKTRLSASMQRWVCNVFRAPDEPRFIEVIEQQRKVGEIHARIEIPVSLVLRGARALKHRL
RELLEEQGLDEPLRRQAARLGADIIDLAIEIMCFAFSQSHDRNSRAEEAYRLFSVSQNIG
AEKERQRAALLDWENQLMFDFAIGNTATGLPQLASSEFGLWFRHKASHAFQGSPESASIL
GYIDSIDRTLGELCEAPPSAERGDLGLLHQVREQTRAIKFLLDSLFEQANDLEAGRDVLT
RLLNRKFLPVVLSKEVLYSRQSGSTFGVLVIDVDHFKQVNDRYGHDGGDQVLQQVATLLA
SNSRGGDYAFRLGGEEFLMVLVDIDASKALQIAEKLRKRIASETLRLQKGGELQVTVSIG
MAVHDGHPDYERLLKRADEALYQAKHEGRNRCVVHSSVS
>A0A564SI27|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MKKRKIAILSVGIIIVALLLEASILKYVNDKNAYQTSKVLVDRVITVLNKNDESRDELIG
SLKDDYIVRAKAVSYIVDAKPQVEYDVEELQKIAKLMSIDEIHLIDEKGYIYSGSVPKYF
GYSFDSGEQIGYFKPMLNDKSLTMCQDVTPNTSEGKKMMYAITWNEDGTKMIQIGIEPTR
LLKEIKQNKVSTVVADMPVYKGMEIFAADAETKVIEGATDDSKRGEKLDAIGISSEQIDK
NQVVVKHVKIDGKHCRCMMRRDDSYIVAVTVEDSVYLQGTLLAILIVGTYLVLATCWMMY
MLSKVIKERVEKEKLLYTSNTDELTKCFNRHAYEKDINDLELNAEWIYISMDLNGLKHVN
DSYGHAAGDELICAAADCMKNSFSEYGKVYRIGGDEFVVITKNIGRFEEVLRNFERSVEE
WHGKYVDSMTVSYGYVFSSEKKWNSVYDIAKAADKRMYESKANFYCEKERDRRK
>A0A2U3KCU4|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MCVLVCAHVLLSLSVPRGFALTAFGDLLQSVLLFCATAAILANVKSASRKTGLFWTLMGL
GFGLWFFVQLLWTYFEVFLRHDAPDPFVGDVILFLHVVPMMAAVAVQPHLRQDDHAVRVG
SLDFTLLFTWWLFLYLFIVIPWQYVYPADRTYGLSFDVLYTCEQLVLGLGLIRAWYRSTG
VWRGIYREFFAAALLSCGGSFLANEAIGLHLYYTGSLFDVPLVLAMAWFVRIGLLAREAT
AKGPAEEVASHGQGIWKARLAMLAVSLTPLLVAWAEFGGNAPQRVRSYRLLLTVAVMVVM
GFLIILKQHLLDQELLSLLRLTRHNLDEMCRMKDALEGKEQSLRWHSLELQRKNLELQEI
SFTDVLTGAWNRRYMEEIVTAEAEQVLRNYQRARGGDIRKLDHRDLVFIIVDMDFFKEVN
DEHGHPAGDRLLQLVAQRLGMVVRKSDVLVRWGGEEFLIMSRSTDPAGTPAFCGRILEVV
AATPFDLGHGIVVRKTCSVGWAAFPWYRGAYEAICAEESIALADAALYRAKALGRNVGVG
IVPSDGAVRNPQAIKVKSVEEVNSRLSRIVLTQCPVQNTASGAQFEATQPTNKSSV
>I3XAA4|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MRLRRASGRANHVQKHRDKRLLLVEDSRMFAAALKHGLELTHGINVAHCASLAAVKAEVA
AAGEWAFSLAVLDLNLPDAPNCEALDFILANNVPAIVFTAAFNDRTRDQILNRGVADCIV
KNEPESIERLIAAVDRVLTKGRTTVLLVDSCATSRQDLAGILRRGLFAVIEASEAWEALQ
VLDQGEIIDVIVTDTGLADLAGLALLEEVHKRQGDDAVPIIGLSDQGDARLAARFIEAGG
ADFIRKPFLEAEFSGRIRHAATLQKRIQALKLAAASDYLTGTFNRRHFFMTGPRLVDQYL
RRGEGTSIAVLDIDHFKRLNDTYGHEIGDLVLKHVARRLKTLVGEEHLLARLGGEEFGIL
FDGLGVRDAFAFCERLRAELAKSKIVADDEELAITVSIGLATIEAPEAFENYLHAADQFL
YMAKHAGRNRVISELTLLDALAS
>A0A379K8J6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MVTTVILGMLCVYLLCFSVMFLLISTRLNGKKMGMEVFALGNLLLGLAYILQLFGGPPDE
GLVSVINHTLTLSAPVVYVLGAMRFFERPTPVLRPLLTLMAGYTLLQLLVQWLLGTEARH
AMLAAACASLFLAMTVVVLYGRRTFARDLRVEMLVFAVLIGGICILNAMKFAVILNGGLA
AIDMSSGFQRIFYIYMSFLATVLPPCAVWLVLRRLTDELRNLAAHDPLTQLLNRRGLMDV
LDAYFRSRTAGPVYLLIVDIDHFKRINDTHGHKAGDRVLSHVAAVLKATARQGDLVCRLG
GEEFVVIALGTDSTGAQQLAERMRAAIEHNEVVGTGVKQPIRCTATLGASGAFTAAQDFD
AFLQLADAALYRGKTQGRNRVEWAGGIERSVQIYGL
>A0A379JQ64|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MGDGNYNDHRDVGAGHCEGLRESGKRKLMRTILLATGLTLGGFAVLQALAGNYLFAILEV
LCTALLLFGAWRIERARHLHLWIYLYLIPTFCFILYIIVMPDASAAAFVWLYMIPLLAYL
LLGKQRAFLLTALFMCAGLLLYFTDNHLTLDAHGLIDLGNAALCGVLILVFVHIYDGLRM
QAYEELERLAQTDSLTGVASRGSFQHALQRSIQDAERSNGHLVLVLLDVDHFKQVNDQWG
HEAGDMALQHICQILQQRLRVTDFLGRLGGEEFGLLLRHIDSTGADPLVDKLRKQIAEQP
LEYDGEQIALSATFGLATWPVDGRSAAELYRAADRRLYSGKRRGRNQLVSADLPAELLLD
KFDVRL
>A0A2H6FV70|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MRVLRKLTTFYFIGIVFIIMIIIAAVFSFGDVYNSTDKILVFTRKLAERNPGFSSLESFQ
LNQLVDEIGRIQLRAYFFFSVSLLMVSTGLIYLIYTYKRNKEFNDTYGHQEGDAALRWLS
NILSRNVRKIDSASRYGGEEFAITLTESSYNGGIRVAEKI
>A0A7G6UYF7|diguanylate cyclase|EC 2.7.7.65|Burkholderia cenocepacia|TrEMBL
MARIAPLPPDGWNGILPARYGWPGTGTVALRTTRHALPRAARMLPQARAERCTFSRKTDL
NQIADAATPSPDTLLRIIAAQAEIAKLGLDLGSVMAYVTEQMPQLTGASAAAVEFAEGDD
MVYRAASGTAAGMLGLRLRRSGSLSGLCVQQGELLHCIDSETDPRVDRDACRRVGLRSML
VMPLTHADTTVGVLKVMSPNVDGFSPADAGTLRLMADLIAAAMFHAARNEANELYLRATH
DALTGLPNRALFYDRLRQSMHTALRASGRLGILNIDMDGLKPINDGFGHRAGDAALREVA
TRMQAAVRRSDTVARIGGDEFAVILPNLGTRDDARVQSMRLARQVGEPFEFDGHALRLGV
SVGIAMLPDDGTDMNALIEHADQAMYEAKRSRRTAHA
>A0A517TXI5|diguanylate cyclase|EC 2.7.7.65|Lacipirellula limnantheis|TrEMBL
MPRISQTEPSQGRSHKEVTSNLLPSRPSDSHGPGQPEATLLFEPDGTIRASDATAARWLV
WALSAGRSRPLTLSNVIGDELADVWRDQMFGTQCVDRLLAKVILPRFGSTPVEVEVRRLD
GEAGPLAIALFFPLRRETPTPGDPLTGLPDRRAIASWVADTRDVTGPRPPFALLFLDLDQ
FKQVNDEHGHAIGDLALIELAERWKSAVRDGDLVARYGGDEFVILLKDIADREAAETIVE
RLRMATVAPIAAAGTTFRLSVTIGIVLSLSDEATLEHLIAVADEDMYARKRRRPK
>A0A080LUY4|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MFSSPPLLPPVDLRADDVEIGNYATLLDSLDIALLVFSPDGSLHLHNTQAATLLGDTPVI
WEDENGQPLADDHRLEMQVAQTRQAVLHRAIGIRRESSGATTWCKASAFPVFAGDGSLRR
VLLALVKLSRYKQLARENQSMPTHDPLTGVFNQTYIELLLDDEDRRARRYGTPFALALMA
IDDFTDFCAANGREAGERVLAEVGSLLGRSLREFDMIGRFGSDQFLLILPNVRVNDAMIG
LERLREVVEATYSRDDRPPLTISGGVTEYSGEDSAALIEHLRPLLNAAQEAGGNRLCVDL
EIF
>A0A379JTN3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MLQRFALVLALLLGLSTTGLAAASVVLTDASSGMPLNAHIELLEDDQGTLAIDDLAAPEQ
QSRFQPANGRASVGQSLNPWWIKLTLQRDMYAPAYWVLEVGSVTQLDLQLYLPDGQGGWQ
LRQSGERVAFSENRDHPYRRMVFDLPTLGEQPKTLYLRAFDPAGNSFPLRVWQLEDLTQL
ATRENLALGAIYGVVFALLLYNLFILISLRDKAYFWYVLTTAFALLFIMSMTGHGAQYLW
PNHPVPAWLDRITLPSLWGLFASRFTQTLLQTRVYVRWAHHLLNMACVIYLIAIVLTLFD
QRYLAAWAIALLSLTSIPAALGSAVIRWRQGFFPAQLYLYGYGLVLGSVAILLLRTTGVL
QPAEWNAYVFPLAVAAESILFSFALAYRIQILKQERAVALQQADREKTARLAQLQASADE
LQAAVTARTAELAATNEQLRDRERELQHAAFHDSLTELPNRRYLVERSESALAHAERHKE
SVALLLIDLDHFKPINDRFGHAAGDLMLQVIAKRLREQVRAGDAVARLGGDEFAALICGS
DAESQAREIAERLLAELSEPVHYGAERLRVTISIGVALYPLHARNFTGLYKAADMALYRV
KELGRSDSRVHGDDGELSEQACLELDVLKVPSGLA
>A0A8G0CAM7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MINSLNRKMTLLFIASLLLVGFIAFSLLNLDRRQQQTNAELDTILEIQNSIAMLRSQLWV
FLQYNDAHSLEQVYRAQQVLAGQLEMETVFGQHLASIQRMNNSLAGLLEQERYMAEESGI
TKLVDGIGTYELLHSRYNILVQNMNEELAYVQRQVMAESINNQRYVLLTTMAHLLLFSSV
VCGIALVVLRRFRHGCKTLQEGIEQMAKGDLTSRISTQNNEQEFVQLTQFFNQMKASLQS
TTVTKDELQAEVARKTAKLERQKAELRFLSERDSLTGILNRRAFKQQLSHALIKAKRSNM
KLALLFFDLDKFKEINDTKGHEVGDLVLQEIAQRLKGSIRESDFCGRLGGDEFVVCLDLL
QDHNGVINKAYQVLEKLQKPLQLNQESLEIGVSIGVALYPEQATQVPELLRIADEAMYTA
KRQSGKAVYCAHQNKHDHTSLVS
>A0A655P7Q2|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLQQFKTSGGKMPDASTFISSEMKEFATTINRIVGQLEDSQQVLRWQSEHDPLTRISNRR
HLEKQLKSYLSDRPQAYLVLFLVDIDFFKRFNDSFGHLAGDEALCSVADVLQSVEFHGEK
IVARFGGEEFCVVLASDCAFDAEQYAQQMRSKIEQLAIANPVDALCQYLTVSIGGVYAIS
PKMESYLSLFHQADMALYHAKEHGRDRYVVRNFV
>A0A192C6R7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MTWLFCDRIATTIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRNEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSTNYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAA
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLL
PRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAK
NDGRNRVLAA
>A0A8B3KCM8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMINI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A7L6JRB8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00524|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A0E1CML0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MKIMTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKS
CYGLKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLP
DGEIAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALM
TDESLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVAR
LGGDEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEKIHTECS
AIMQDADERMYEIKKGKR
>A0A0M2WMB3|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MSARMSNKPARQPRRTLDSVLRRAHLSVSLIAVLAAGLTLTAVALLALRVYSDQNLRLVA
RSMSYTVEGAVVFGDSIAAKEALALIGVNEDIDQAQVSDTAGKVLARWERGEHGTRYYIE
RALTGWMLPDSLTFPITRNDQAIGSIKLVPHSRSLLPFLLSGLTCLLACLVLSLVVAVRL
SRSMETEITSPLRHLAEIAHRVRRDRSFELRVPPANIAELNQINDDFNALLDELEAWQSH
LQKEHASLSHRANHDSLTGLSNRAFMEAELERAILEARVGNGKVAVLFLDSDRFKYINDT
FGHASGDRVLVTIAARIKQQLREGDLVARLGGDEFAIVLKPLRNSSDAMHIADNIIAAMA
QAIELPTGNSIVSSLTIGVAVFPDHAIDAISLVGAADEAMYRAKQVQRGTRQVARLPQPH
THP
>A0A174H8R7|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MNFEDVIQELEKIAIDEEYINIICSKINELELKISKEIYEKLIDYVKEKDLKHAYPWIIH
NYGWIQHELGNFNKAIDVHIEAYNIFQKQKNSEGILSAINALVGNYSFIQQFDKAIEYGM
EGIELAEKCCNYQALNSIKNNMSITYVEIGEFEKAKELLEQIANLPNINANHNKIVNLMN
LAECERELGNYELSLEYLESALGIAKSFATTLIPGVLEQMGRTYCAKGLYNIADEKFQES
INISRETEQKLCLNEALLYWSEVDLRVGRYKEAIIKLKEVEENIEIVNSIRNKNKIYSNI
SLAYKNIGDYENAYLYLEKVNMLQKEIFNKTRRESIKNLDKKREEEESKVYKFLYNQMEV
LYSVGQRITANLNRKNIYKIIAEEIKNLIQCDVLQISLINDEKKTLEYKLCMNLDDKLEM
PPINLDDENRFGVYAINHKQEILINDLKREYYKYFNNFEDFIEKLAEEQSRTLERFSQSL
IFVPIMIHSKVIGVIGVQAYEKNAFTLKDVNTLKILSTYIGIALENSRLYKEIKYRANYD
VLTKIFNRREALRKSEKIYNKVKKYYDSYWVMMVDVDNFKKINDTYGHQTGDKVLASIAK
VIKESIRECDIVGRYGGEEFIVIVKDDKNSYLKIAERIRNNIENTVINIGENEIIKVTSS
IGITKMDATDKTFQQIISEADKALYKAKNSGKNKVVAYY
>D2AD39|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>D2AEM5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MQHYFYYIHSKHITSCFIFVDDVLSCLQRLNNQHLPAVSWSCSVSDQIIARVSQSLAKEQ
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVLWDYSLC
KRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
RAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHPALHS
>A0A0P1FZR6|diguanylate cyclase|EC 2.7.7.65|Tritonibacter multivorans|TrEMBL
MKPGSGSQEPAKPHPLQGAELAARGLLSLLLLGLCIKNLMIGLVPLAAALAVFDLMLLLN
LFADIKRGTRPVSSRIMCCALTLVLLCSTASLGVGGAIWVFPALVSARVLASRGGSVTMA
IFLTAIVPAILAFNGDPANAARMFGALLLTSFYVVFAQGHVPTFGEAIDMASMRDPLTRV
FNRARLDRVVAELKPQETAGLLVLEIENFSQMKQSLGHAAIDNALRQVAETFHGFLGERE
QIFRVGPSEFMILLRGWSEHETHALADRVRAHLVQCEASQNLAVKISVSSVTGGETPGDA
LEDVQAQLGRLRNLG
>A0A1N6M619|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MKKRFSIKGRLLTPLVFALALVGMLFEGHIRQLERELGEEYERIEREFFRASKMLTILDY
SLNNYIKVRQSLILTHTTKIVNGVCQMRPKFVATDAEERSNAHIQALEYIIVGDKSLCDK
NSKLHHEVGFRIALAPVISLLHDLDDYLVGVHYVDPSGYIISSPDTLSVNATTDVLEQIQ
SPNWDVYQDLGENQPINVRGPMVFQELQSTEDLVSLMLPVYSDHQFEGVISLNIMLDKLL
NTNQRLAGKLHFIDTQRESLPTNAFQPHSLQGEGISFHHAMYYDMRWGNELYQFVSLKRK
TLTLITVMYILAVMSLLFMNTRHAKSYYEGLAVRDPLTGLRNRRGFEAFIEHSPHQSYVA
IAMIDIDNFKAINDHFGHDIGDEVIRYVGDQVRCHIRATDTIARYGGEEFVLYLTAERKS
YLKKTLTRVKDALCGESGTIVKGGFTISGGVEIVACRELNDIDAILKSADEKLYIAKKSG
KNQLIF
>A0A6L6YCT0|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. 10-1|TrEMBL
MNKDYPQGPRPTFKRALRRISMISVIISMTLVWLLLSTASVFTLKQYAQKNLELTAATMS
RSLEAALVFGDSAAAEDTLATLGKQGQFSEALVLDSQKKHFALWHNHDLVSQEKLSGLIS
RWLFPLPTTQPIWHEGKIIGELRLTALDRLISHFLGISIIVLTSSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINKLMNDDVTHRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMTFAGTEHQAWRLGGDEFAILLRNVHTEAEVQAQCALLSAQFLQPFNL
HNGHTATLSLSIGYALAWEHTSAENLQEFADQNMYRMKNQRLQQVQK
>A0A5P9IYI9|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MQEELLNSVIKITKTRDVNSLEYSLVTTLQEFIQCQEIAVYKDLQDFGRKVIECSLVLHH
ENAGQYQWHDTHIVESPESELLSCLQSACIITVQNNNGIEHRWLPISIFDKPVVAIKVVS
NHLSSSQQVLLNAFCRIYENYLTILHENERDKLTGLLNRQTFERKFKRLLEKQVMNQKAH
NRENNNRKRQPESYSWLAMVDIDHFKQVNDNYGHVCGDEVLLILAQQMRGFFRASDLMFR
FGGEEFVLIFEPCKQEDINEKMQAFMDHVRNTHFPFVKTLTVSVGMARISPYDFPISVLE
NADKALYYAKNNGRDQLHFFDDLVQSGAISPDNANQDEGDIDLF
>D6I945|diguanylate cyclase|EC 2.7.7.65|Escherichia coli B185|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAERWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELAMLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1Y6M7M0|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MDRKRKTIIFLIVTLVITIIGIAMIENINSTYNKQLIHDINNKAKENLAALRFELESSLV
NDIYLTSTLADIATIDFENRNEVLNKISEAVILKSGHLTSIGFAKNDIVDFVYPFENNSK
AIGLVYKNKPKQWKDIKKARMTKQILISGPISLIQGGNALIVRVPVFYDYPNKNQYWGVI
SGVINYDKLFKTLTSMKNLEKYDLSIINESDNKQPTLIYGQTKGINNYLFYEEVKLPYGK
WGIYLSHNKNNANYFNDSVRIIAYPLFLGFIILFLSIVILYITNEHHAYHDALTKIPNRR
YLTKKLAKLFKQAKLGNIDGTFVIVNIDVDKFKNINDNYGHAAGDKVLTVLSRRIKNNLR
KNDIVARMGGDEFLLLITFKSDNQNIKNRVFDIVNDVTQEAILFEGKQIPISITSGYAVY
DESIENLWDMLILADKSMYNKKAY
>A0A653KG44|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MSSPPAFFHCSGRHIGPLLIPLLLIILACLPARVAAQDPIVLQLKWHHQFQFAGYYAAIA
QGYYRDAGLDVRLREAGPGTDVVDEVVSGRAHYGVGSSDLLLDRQRGQPVVVLATPFQHS
PLVLLARADIDNVHDLVGRRLMLEYHSEELIAYLQHEGVALGLLHRQPHTLSADALIRGE
VDAMSAYNTDETYTLQRSGVPYQTFTPRSAGIDFYGDNLFTSERELRDHGARVRAFREAS
LKGWRYAMLHPEEVVAWILTQYPATNNPALDRNKLLFEAKQMQPLIRADLVEMGYMYPGR
WQHIAQTYMDLGLLTAMPDLDSFLYSQQEERAHQQQLMIYQGIAIGLLVSAFLLILLMIF
LRLNRRLREESKARHQLSQEIADNERHFRFITENSADVIWTMDIQSGRFTYLSPSVQHLR
GFTVEEVLAQTGEELMTAESADRIARQMKESLATWAAGDHINTKRVTLVDQPHKDGRLIH
TEVVTTLHAGKDGNPVSVLGVTRDISDRKASEEMMRQLAFYDPLTHLPNRRLLQDRLQHS
LQQADGKPLALLFIDLDHFKPVNDQHGHEAGDWLLATVAKRMLHCVREGDTVARIGGDEF
MVLLPEITGEAGAIAIAEAIHQSLNQTFAMTDALHFHISSCIGVALYPQHGTTQKQLMNH
GDQAMYQAKEAGRNRIQLFTPQMAGGITREAANQMQLGWKQSHDCGHPQIDDDHRQLFAL
ANQLLNGVLTMEEDTDQFHQNFEALLALATRHFNNEEAILAKLEYAELDTHRQEHQKLLH
RADSLYQAARTGELTNLALLDFVLQDLVLGHMVKQDRRYFPLLQASMQEEALLSPDGPLA
SPPPGLVKH
>A0A5E4RDX6|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MNRTLLSAASLTGRLRLQNLAVVAVVAILCIGLFAMAWGTFQRAGDARAALDALRATLLA
MEKASAERGPANAVLGADLPLPNESVAALHSAREVTNARLQALLSALSASRCEQCGPSLR
AVERARLDLAAASANVDLLAQRPREMRSDAAVRDAVDRMVRVIADFTPVASSRINVVSRG
APDALHFLVLARLAADLREYAGQLGSHFTATLTTGQSLNDTDQRAIERTLGRIEQLRDMI
ASRMTDTAVLSPQTLDALNAQYFGSGLRYVAAVRALAGQPHPKAPTTAEFAHSYVPTMRA
ITDFRDNMLSIARRKVDEQYASALRRLICTVLAEVTLVLVVALVLRNFRRGVVQPFEAAG
RFVDALAQGNLDVAVPDERLPMRRPQVRAVFDALRVLRLNAVELAQLRRERARLLGELEM
SADTDPLTHLMNWRAFERQAQALCATNAPGRVALIKFDIDHFTNLNATYGHALGDDVLRR
VGAVCLNTCQPGDVVARLGADAFVILARVLDESRARQFAELLRGRIEATTLTLPDGDGLP
LSASFGIAMADPVAFDAEGRALGMPTNVSALLSQAERQLHAARQARRHALD
>A0A4R0DTY8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrestris|TrEMBL
MNTESIAMLAEQWKSICDGYSTTDVNDTFQFIQAHSQTLVYEFYKNMMQEKEASYFLSDD
IVQSRLKATLNQWLIDCFQVPLHQNFEPIVQKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFVLQAEQDQENSLRMISYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAA
QKDKQRSSLLNWENELMFKVFSHEPKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVKAIVD
RIYQIDTLSQQVLNIAEKDESIQLIQDIREKNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNVPLSLLAIDADHFKRINDKFGHAAGDSALQFIGEVLLDCI
KGSDYAFRVGGEEFLLLLVDSDLIRAQEIAEQIRSRIQETTIGTRPGSSFNFTVSIGCAL
YDGHPDYQRFIDAADTALYAAKNSGRNRVYLAKNELRNSNIDSTVHS
>A0A173R6W7|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MKQKQKNILLIAGMLLVMLVSIFVYSFYTQKQIYQESTANLLSTYGQSAKTFTMFAQRNW
NILTDWDSYLGALAERGEQEGQWQEYIAQKATWLYTDFYLFNEQCEFWTTAGRQGTAEYM
KAAFEELYTANKPVISSYISDQGIRKIMFAMPMEQPLQLDGTTYTALAVSYDNAVLEKLL
GSMVYEGQSDCYIVRSNGDIVLSTEVKTEITEQMTNLFDYLRQNASVDQPYFDTMVQTLP
QGGEGCVLYTLNRQKYYLIYQPLGLMDWSIIGIVPTGVVDAGMRRVQNATILVIALLGLL
IMAGVVKIQRDAERNRRRELEHHREASDMMFAGMARVVERFAVCDLDHDRYQYHERHGEP
LYQPEGSYQQMLEQISRKYVVLTDSENAKIPQMLAPENLRRLIKTDNDSLKLEYAARDKS
AFFMMTVVPMAWRGDRLTRVMMIVQDMGEQHLLQSLANTDGLTGLLNKRYFDQVLTVLEQ
HSQPFALFYMDLDRFKPVNDTYGHDVGDELLKGVSQRLQSCIRSRDYAFRLGGDEFALLL
IGPMGPEACASKMNLICEMIAVPYEIEGNTVSVGASCGYALYPAESVDVQQVCYIADQRM
YENKQANHARQDGTEDI
>A0A1Y6M7H7|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MIINIKALFKNSLRHFKLFSLFFIICSGLYFIYNVYNINKLHDQYISTLNNVYSAARRFG
SFYNNTGTEDLKDGQYLFNDVSVVVNTSTQAKILSTGINKLRLQIDKLTENHIWTVAVFE
TSAKYSHFDPLRDVYLKLYDHVVLNSIVKNEGLIDTYQSFYGCNIKLTDVYTEQGTGEVL
RTVYFPIYNNKKLDALLAIDINNSMFKNMLDNYNRNKMTIININNNNIYQTSKLLPCSEV
DPIYLGVNFYTLLKFTFLPSILLMFVYHSLTKIIAKKNFILRYDQMTHFYRRDYYETKLL
NQSDFNLLIIDIDYFKKVNDTYGHEIGDEVIRGVTKRINNCIRNNDIAIRWGGEEFMLSF
PKMNSEQLTKKAQQICDSIALYPISDIDIKVSIGGISSKKIHFNDAYKAADQALYHSKNN
GRNQVTIV
>A0A8H9DAS9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWERELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLQLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H8ZAD3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3T2UV88|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKYPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7Z1EMR2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENTLNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A0H2UY84|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A3S4J7B4|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MPEHVHNIVKRLILYICICLLAGVGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNARHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A348DBS1|diguanylate cyclase|EC 2.7.7.65|Metakosakonia sp. MRY16-398|TrEMBL
MGQEKVVKSPPRLAFVKTWFVPSRVVNLCFVIVLVCSTVLTWREVIVMKGAYVVSQRNAL
DNVTNVLDRQMQVGIDRLLFFRNGMQSAVQTPLAFDVLRNIQAEFEKERILPYWQIGLDN
RRTLPLYGVSDYFVDQSALLSRDNPLLHNELTAAMELGYLFRFSSSASMFPRRALYVSRA
GFFISTLPVGNNNEIVQQYYQHLTSPWFSGQSERENKLRGVRWFSDEAHTPNIADSLVTA
SVPLDFQNYWYGVLSMSFPVSSMKALLTEARQSQDKGEYQLYDAQFTLLTTTADAGTTSQ
QFSSDEHAQLQREMARDTAGGLRLGTRFVSWVKLKHFEGSVLRIQTLHEGLRGDFGSISI
ALALLWLLFTTMLLLSWGVIRRMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERAQVLT
TECAAQNLPLSVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEE
FCVLLPGATLADATAVAEKIRQRISSKEIFVQKSKTIRVTASLGVSSALESGNYDFEYLQ
SVADSRLYHAKNNGRNQVCAEDGVTPLPNT
>A0A1H8UBH1|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MNFSQRYSSATIVSALRIATLGAICYAAGSVGVLLILNLLMPDRPFLVGFAGAGVISLFV
AFPLLLILQFKVSELRKLQETVNYTARHDSVTKTLNGTAFAAAVEHYIDRRKRIATDAGG
VMIAVVVDTLDEISRRYGPQWADTVMQSLAAIIQSSVRKGDLVARLATNELGVFLPGATV
ENAQDVGTRIRRRVAEASFSAEGTPMTIGIRLGGAVFEGPTDFNHIRQLADEMAMQRGGE
SEDAIPMSRLPAA
>A0A0D8I2M2|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MIVSFSSLEFNAKIGVMRTPVHLPTGGNSWNLLNEWYHEEHDYEWMKRQRSSRAIQPLCR
ALLGIMSMIFGLTALVKLVGPDAPPTTLGKYLGAIVVVSCFVIAGLWFTRPFPGRHGLIA
FAIFADIGLAGAVLMVTDRDSATFGCIAFAVSGTYATLFVSAKWLLGHVAWATGVSIIVF
VLAFGAGTVDHGTLLARALVLFAAVTLLPIFSHLTWRMMYRDARESDHDPLTGLFNRRGL
DAAVTVLFDQARDDAWCLAFIVVDIDKFKLVNDVHGHPAGDRVIQRTANRLSAHLGQRAV
VGRVGGEEYLAVIAGPPEMIITLTEGIVPALSDYPDPIRTTVSVGVAIMPTESKAWTGGS
SAISVASNVADSMMYQAKAAGGNGVRTTSI
>A0A5E4UFR2|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MSHSSPASHDVDTPHDSPQDVANEVAQAARALWRTNGAPPATGATPPHLPSDDGRGRIDA
VPDIIDRESPLATARREMTASGADFHASHAPASPSRRGLTSGVPLDEAERLAALRRYDIL
DTPPEPAFDRIVRLASYVVGAPISLVSLIDESRQWFKARQGIETTQTPRSIAFCAHAILD
DDVLVVPDARDDLRFADNPLVMGDPNIRFYAGAPLRTPEGHRLGTLCVMDRRPRTLDDEK
RALLADLSALVVDALELRRVNKVLGDMAMRDGLTGVLNRRAFLMQAERLFSAARAQQRRL
SVLMLDIDHFKRINDTWGHAVGDRVIVELTQIMRATLRKGTAIGRLGGEEFAVLLPEADA
QRAMQAAERLLIAIGGASVPGPSGPKVPAGPIRFSASIGIGSLTPDDAEFGTLLQRADRA
LYTAKQSGRNRVAVA
>A0A379AAX8|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MAFKAVNDTWGHHVGDRLLVAVAERLCSQLSNTMLLVRLGGDEFVLMAECDISAARQLAQ
KTG
>A0A1C3JB65|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MPSGSSKQWSARVVAFLFFLAIVSAIEFFHAKQLTFLKNESYSQAKKQLSIIRSRIEAAI
VSDMYILNNFSTLVTINPDGEVKNWDKIAENIIQDGFHIRLIGLAKDDILNFVYPLEGNE
QILGINYRDHPNQWESVEIARNLGNTFIAGPFELFQGGQALITRTPIFRDPPFNQDYWGV
SSAVIGLDELFEDVGIGKIEKKYELAIRGANSSGKDGAVFYGTQDVFDNAFANEQVSFPY
GGWYLALSGNEHVLMDEPWYRIQAVRLVGYSIILVLAFAFFTIYRLYRIADSRSMHDELT
MLPNRRYFMYSLKQAFKTTQKQRARTFAVVNIDLDGFKAINDTYGHAAGDQVLIECANRI
RSELRVSDIVARIGGDEFLVLLPRIIDDQHVSSIVTKLRKAICSAPVVYEAHSIYLRISV
GWVIHNSNYNDVDALLKAADEKMYEQKRQVI
>A0A2S8VKG2|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. MYb9|TrEMBL
MSSSNGAVPAWTGGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKDLVDAFY
STLLADAEAGPRLSHEIVSTRLHSGMKHWLKGLFCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAERLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVMRLDDVVLPQLMLADAQQQVPMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREIAISRRQGSRFSVLLLDIDHFKAINDA
HGHAGGDQVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGQEAAVAAAEKLGAEIRR
HAFSIPEAGALRITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSVAA
>A0A839WB64|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. OGB3|TrEMBL
MADELFAQLTDTLSSAKTVEELTRPLLSLLELVTELEATYLTRIELEHGIQRILFSCNTK
TLTIPEGLAVPWEGTLCKRALDEGKLYTDDVPGCWGDSEAAAALGIRTYVSTPVHLDDGS
LFGTLCAASSERKPLTPKGEQVLRLFASLIALHIQREQLLTQFRELNAALESYSYTDALT
GLPNRRAVVAELHRLFAMAGRTGQSVLIGFIDLDGFKAINDTHGHEAGDEFLTEVGRRIG
AGLRAGDTLGRLGGDEFIIVGMGATPGAEGDDAADALRERVTPLIRGAYRLGGCAFDYPG
ASVGVVSADPGTTTPDDALRAADAAMYVQKKIRRAAQA
>A0A0T9T9K9|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPKTPAVTLPIVMITVFSLSAAAY
LVFISKKYADKLNLFSIILGLLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FIAFCLHTAPATLTVIFLDDFQNIFRIIFTLMLPLIGFSLHHLMSRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVAFAGKKFSNVESSP
>F8JCL9|diguanylate cyclase|EC 2.7.7.65|Hyphomicrobium sp. (strain MC1)|TrEMBL
MNFVVTRWVTDLMRDSDIPTRSIDLLLSRRSDNGGLAGISHFDWPSSGLPPFQDWPTALS
MAARLVAHASVPMALMVGREGHLVPNAAATVLFSEFTRGDFLGRPVEEVVGEGAKFYADV
LSRVFTGESCSFHDQPMRLVRNGQWATRWFNLHFTPVADAQGQVLGVLAIASEVTSHVQC
ARKLRESEQRLKLALESSGMVGVWDFDVKTNISTADANVARMYGLSATGCVRGVDDGHFI
RAIHSGDRARVEETLHTAIETRTSYRCKYRVLPHGGALRWVITSAKPVYDDRGDLVRMSG
VVVDVTDQMETASALAQSRFQFETLTEALPQIVWSCDAEGRHDYFSARWSEFTGMLSHEI
SEDTWKMLVYPAHWDMVRKKWGDAIATGTPYDIDYRFRHHSGEYRWLRVMALPIRDDEGN
ITRWFGTSTDIHDSYLAAEERARLTKELERMATEDQLTEVLTRRAFINSASAAIAQASAH
AAPVSLLMMDLDHFKSINDEYGHPCGDQVLAAAAKRIKACVKKQDLVGRLGGEEFAILLS
GCGAREAKAVADRICGALEARPIAMENGLSVAVTVSVGATTRSAPDDDLASLLLVADKAL
YQAKAAGRNRSVFHESVADQA
>A0A8F9FW78|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MKRTTLRQAIGPASFVLVALVCWFLSGLVADRMVQQELDAALRQQRQMSSSIVYNMAEVI
ASDLAMSRAIPATMAELGVIQQALSHAGNFTAPGIDAEPAHRNELLATQELAAVNNFLHD
AQGFSGLDIIWLVNANGLCVAASNAQSPQSFIGLDMRSRSYLTNALLGAFGEAYGVGRMS
GEPGIFISAPVYDDGLLVGAIVAKVGIARLRHWVAHAGTFVTDDNGVIIMAHNSTLEGEA
MPNSRVTQMTAAERMSTYHREVFPAVQIQPVARQVRRDAPWVPDDVAAQLFDMPGQTIPT
LYQSRSGLNSGLSAHLIDPLGGWSELLRNHKRDHMLVFLTLAGTVSLAWVITVSYLRERR
HHRATRDLAEQLQAANTLLSAEARHDALTGALSRRYFLDLLRHEIDRAHATGEPLCMAIA
DLDHFKQINDRFGHATGDRALEHFVDTCRNALRGSDAIGRLGGEEFGILLPSTALGAGLD
VVERLRIGLKATPCAKLPATAGLSVSIGITELSQEDVPERIVSRADLALYAAKSGGRDRS
AAVPPDDTAPPARTPATAL
>A0A128FH91|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MARGSTAWSAVVTLIFFLASFAGTTPFNLHDANIAQVSIASGIGMIGCLYGGIRTLFSLI
FASTMAFGLAIYNWDPTASLVPALITGAIMPLACYLSAQVWKNLFSHSGVRFETLKHYVL
QICILPGFLLSLVTASDSLYGGYTGEGGYFYDLYELTSTYALGILLVAPFYQLWRLEEDP
FRQFSRNAILNIILYLTLTILAFVGGAPGLIFVAPVIPVILSFKGDELASLAALFGMGII
VTMIAPYNLGPFNLPNKVEGHASLLTYVLMSVITPLAIGLHVRRLNVVSRSRDKWQSKAR
TDQLTGLPNRYAFFPELTKQFEHASKGGKKLVVAMIDVDHFKMVNDSYGHAAGDVVLMDI
ALMMQEEMRDSDLLARVGGEEFAILFPGANEAQALKALERLRIRCESHISRYQEVELSVT
ISIGAAVFKASETKDALLGRADSLLYQAKEDGRNRTIIS
>A0A0J6VDX8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MDFAAALQRRMLLGYLGVLLVLYLSSVASAWGMSSVRGEIISVALCVVGLALAARAPLGR
LRYGLAVTCLCAVPVAAMVFHDVDAAQVWAVVPLMFSAIFVRAWHRPATARVVATAIAVA
AGVALVVAPADVPVQWCGMFAVCILAGAEIVGVLLAALYDAALRDPLTGAWNRTGLERRA
SELMSRAARRAESLAVIALDIDDFKVLNDSAGHAAGDRVLAQLVRDWRGQLPDQAVVGRL
GGDEFVVVVAGHDDTSALALAQRLAAGGPVQVSAGIAVGQPLDARTLEALIARADSDLYR
AKRERKRAS
>L0NC19|diguanylate cyclase|EC 2.7.7.65|Pseudorhizobium banfieldiae|TrEMBL
MLDRLSPLKQGMQPGRLTRVISVSLLLLLSLWLPGVGTVERLDSQLIDFRAANAPRTASN
RFVYLAIDKESLDHVGTWPWPRSIHAEIIDRLVAAGAGDILLDIDFSTPSRPAEDQALSA
ALLRAGGGVILPVFLQRQNVDDPSSATITRPIPEFAKNAWLAAADASLTEAGQFRAFDTF
RGMDGENFTSVAVVLSALPEAGLPEQIGIDFSIRPDTVRVISVADLLRNKVPADMLAGRS
VVVGAYSTELKDQFPVPIYGILSGPMLHILAAETLLQDRVPQPLVSWPIYLITVLLVIAA
TIWRRLTSIPVVAAIAVVISVASELAAYFLQKQWSFILPTATIHLILALGFTALLAAKLD
LTTLLAELASAEKRNSRRILKRVIQDSVDAVFIVNDQGTIIDLSRAAGSLSCSSWEPRRG
SDFCEGAPAVLVAALRRSIAAFTEGNRNAPAIQEEFDLVCDGQKKHVEAVLTLSSLEQSG
SGSDEDHGRSYAACITMRDITARKVYEAKLRRLSQLDDLTGALNRRELINRIRESAEEEK
MLAVFAIDLHRFSTVNATLGRYTGDQVLQAVSRRLMAAARKISEVPDVGLVGRLGGDVFC
VVLAVSADNPLSFYADKIVGVFSKGINCGSSRIDVSVRVGAALASDVAGGPASWIDAAEA
ALDQAKKVGGAGWAVHTPVEAAAEARTRRLEKDMRPALKRGEFFLVYQPQVDLKTGAIVG
AEALIRWQHAELGLVSPMDFIGIAEANGFICDLGRWALEEACREAVHWPSDLTVAVNVSA
VQFAGSDVREDVLHALQVTGLPPGRLHVEITESTFALDAKKLLEDMKRLKALGVTIALDD
FGTGYSSLSYISDFPFDLIKIDQSFIRRLTEDAASRAIVHAVTGIAAQLGRKVLCEGIEG
ETERQLLSVMGCQFGQGYHFGRPGPTSQLLALLNQAKPPVELTA
>A0A0J6YCL5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MRRLRRSAEHHLWLSEYLVARGVARRTRLCLAVTSAAMAAGVLTLLFGAGGPQEAGAPAL
MWVAFAGGMFGTAMWLWRWPSHAMSLAFVAVTTMSVTAACLAYPDPLAALLGCIAFTTIV
GYAAFFHSPEVVAGVLLVVAAVAVDQAAGLAAQGRFALAAVDLFLILQCSIGVALALYSL
VRTLRGDLAAADLDPLTGLLNRRAFRRTVGGRLSNHQGKGGYLLTALLDLDDFKAINDTH
GHAAGDQALVAVAEALRATATPSAVIARSGGEEFLFADFASAHDVVARYEELCAVIAGLP
VSVTASIGTSFADLAALTPRSHNELLDRLIVAADQAMYDAKRQGGNRCHHYGSVH
>A0A0J6W4X8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MSGWWRQAGRFDSFSSYLRERGLEKTWRYAIFAFTWVLGALPVVLLASPVGPATPVTRAV
AVASGVCAVAVSTVWLLGWPTRVQSLVYNVVCCGCIAAGVLSMSYAYAGLMGCVVFAVLG
GYLAYFHTLVDVLGNFGVAATCAAITAGRLVADTGDVAVTVAAVVTVAALNIGVPFGIYS
LVHSLHADLAESDRDPLTGLLNRRSFSQAANDMIAAQQIGTGVNVTMIDLDDFKGLNDSR
GHAVGDQALAAVGELLRRTCGPTAVLGRLGGEEFVVADAGAAAEHTETTHAIRQGVAGLP
FGITASLGTCTAEIGEEAAARPEFLDQLIGIADAAMYQAKRAGGDRVEQRLLESPRRPRG
>A0A8G2EHR8|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A7W8T0U5|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. MM5384-R2|TrEMBL
MTLPSASKTPAKTVWDRASSRPRHTVILCFGVVFVVTLILAVHQYFLVRARELDNRSHRL
EIQARVLDVAVRNNRQHLQFLRESAERLLADRTAQFDRTPDASLQAVLRAQDERVWNLQV
RDIDAPIRGIGTQQLAVTPDLHRDEPTFVEDLRLAQLMSRLFAVQFQMGTGLERAVYVSP
TGIVVAHPTIDDDEVVRLLQMYGSSRLLQLANQNPLDYDVTFDPVRGRKNPAGPRLLFGT
PVMSNDVVRGLIFFVVPQRIVQDYLWNNTTADETHALIDPSGMPVATSGSTFSVNDENWL
KTLPAQWNTLSASTLFRTPSGTLSAGQDFLLFRKLDTADLVLTDYVSAATVFFSVVRLSS
ALFAGVWILMALLLWATLFVVDQLLSTQMALNGRLRELSLADPLTGLANRRRLNEEFDAL
SRRNDERRIALLMIDIDHFKVINDNWGHAAGDEALKHLANVVRIAVRPGDLMARLGGEEF
CVLLPDTTADDAARIAERVREAVARNACVLQETQLTRTAPGREIWFTISIGVAESVSDNC
FDLEGLIAIADQRLYAAKASGRNRVVASESMQS
>A0A448EIR7|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MPLMAATINFDEVLADLEQLQHTDMQSAITKLHELEADFEHMTRFQQGRLLVFKGTSFIY
SGQYQEALDNLIQSENLVQNSDYLFSAYSYEATAYIALRNFKDAFVVMSKSLGLIDRIDN
IDIKRAAYLRLASLYSAMGIKEEVGTYAAKAESLASADNVKDICTAKLYLSVYQLELEAF
TKAFDEFQYTHDFCESNGFPLISFIALKGMGESKLRLQEYSAAVALLLKALKGYESFNFQ
LEINSVHSLLTEAYFALKQSAEVVEHAKFVTSLPNDPSYTELKHTVFKVLAGLNAENKQF
EQAYEYSKKEQYYNQLMFDEAKMKTLAYQAAKFNADEQSREINLLNKERELYVAQQTVKE
REYTNMLMFVTILVGGLFFLGILLAVGQMQKRKFMRMARMDALTGILNRGAGQELGENLF
VQATARGGDFCVILFDLDFFKRINDSFGHGTGDWALKKVVDSLKSHIRNGDVFARIGGEE
FAILLPYADEEKGMEVAEQCRARIEAIDTQHSGHKFVITASFGVSGLMADDLSLDPLFHR
ADMALYAAKANGRNTVVRYSDILKCDKQATDLRRHIASPSV
>A0A3S4PBU5|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MLRPLRYLSFTLLLLLLPLSQAMAEEKTQVDKIFERFESGEPMTREAINSDLALLSKLIA
TDDVLRNEKLQLLKCWDQSAETDTDIAQAVKNTSQTLTLIPPTASAHFITDLMLCHSWFL
QLNGDVDSAMEGYNLSVKRAYEHEDLKLIADSRSLRGALYSYIGDFSAALDDLITAQDLY
ESLNLTGWANINLADMATSFRRYGDPQSAIRYYNKLKALYLKNNNQEQAMYVTSEIGLAL
DELGEHQQAIDHFLLSYQYFKEHQLEKVAATMATDIAFSLIKLHRLNEAEKYLTEAAAVI
SEKDYAAYSFMKLFTANIKFQQARYKEALTELEQGEKAFRTLQNDRGLTQLLQLKSDVYA
AMNNLPAAYGALQEFVALTKKVDDNSFSHQTTELKMKFDTTRIESENQRLIENQNLKEQE
LALLEKNKSLQHIILLLTGFILTIVSIFAYKQVQRNRQLQVIALTDYLTKLPNRRHIYAQ
AAQYFQQALKQQSPFSVIIFDADHFKKINDNFGHELGDRALLTIASASQALTGNKDLIGR
IGGEEFLILLPNTDAERACELAHQLQAQISRLGAEDLPTELKLTFSAGVATLAPQPNSDN
TYQDKDFASLLKRADDALYEAKNAGRNCVKAAKNEAARES
>A0A1Y2MJQ4|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia autotrophica|TrEMBL
MSRVERELDLARRDVTSSAVLVLDLDHFKRVNDEHGHLAGDEVLRAVGAAVTAEIRDRDV
AGRFGGEEFLVFLGGLRGRPPSCVAAARDAAERIRRRVRALEVQVSGDSGSQPLRGLSVS
IGVSWCSPGAAALPDLLARADEALYVAKRAGRNRVEVHEGEAEHRSPTSPG
>A0A1J5S4D3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNAPAPRRFHLLFDFVPRAVSVIAATVGALVLIGWVFNLDTLKSVLPGLTIMKANTAVGF
ILASVALWSIETSSKSGPLRIGTQACAALVMLIGLLTLGEYLSGADFGIDQFLIPETTHF
PGDIPGRMAINTALSFAGLGAALLLLGLGQGGQVTVIHALTIGPIILGGSALIGYGYDIE
DFLREKLNYTPMSIHAATVFVLLAFGILNARADYPFRRFATSSNPAGVMVRRLLPAAMAF
TLATGWLIQRGYRAGYFGETFLLALFTTVSVAGLAALILGIAGTLYDAAVQRESMEHALR
ENEEQLNTIISILPTGLWVLDAEGKISFSNPAAQRIWAGVSHVELERLGEYKGWRVDSRK
PVGAHEWAGARAVEKGETSIEEEIEIECFDGTHKIILNSAVPLRRLDGSIRGAVTINQDI
TERKRIEDELRRSAKEIEDLYNHAPCGYHSLDENGLFIRMNHTELEWLGYDREEVIGKMR
FPDLLTPSGLQIFQENFPVFKERGYVHDLEFELKRKDGTVFPILLSGTAIRDAAGRYVSS
RSTLFDLTERKKLERELERQARIDMLTGLNNRHHFFELAEQQFARDRRHGEPLSLLMLDL
DNFKSVNDTYGHHVGDAVLQKLSKVCLHTLREIDTIGRLGGEEFAVLLPETSAGQAQEAA
ERLRLSVESAAVKLENGDSLHFTVSIGVSSVETTDTGIDTTLKRADAALYKAKNGGRNRM
CSDDTARSEASGNLKK
>A0A1J5RBQ4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MMANVMVVEDEGAIALDLKRRLGRLGYQVTCVAASHDEAIAGVAAGRPDIVLMDINIAGA
VDGIETAAEIDVPVIYLTAYAEEKTLERARATAPYGYLVKPFSERELHATIQMALQRRQV
ETCLAGRERELAAAYATLEEAQRELLTRSAELFQEKERLLVTLQSIGDGVISADHQGGIT
FMNQVAEGLTGWSVEDAVGKQVSQVLTLKDENGGNEGALPAELMALARQGHRAVGEGVLV
ARDGWDSYQVENCAAPIRGRGGETIGVVMVFRDVSAARRMAEEIQYQATHDSLTGLINRR
EFERCLEAAIGSAVREGHHHTMAYLDLDQFKTVNDTCGHVAGDELLRQITGLLRAALRSN
DVVARLGGDEFGILLDSCPVETGRKLMETVVKTIGDFRFIWAERVFSIGASVGLVGIAES
GVSGGMSVKTILSYADSACYTAKELGRNRVQLYQPDDLALTRYLGDADWFARVCSALDED
RFVLYAQSILALDADGRHGTHVEILIRLKGDDGAVISPMSFIPAAERFGLMPKIDYWVIR
HAFAYIAADPGRAAGLYAINLSGALVSDPQAQDYICAQFDAYDIPPACICFEITETAAIS
HFGNARTLLHELKRRGCRIALDDFGSGMSSFGYLKQLPVDYLKIDGAFIRDIVDNKVDEA
FVSAINSVAHVMGIKTIAEFVENEAIIAKLKTLGINYAQGYAIDRPQPL
>A0A1J5SRG3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSGILEDNAASENSEHALGSLLNIRFPTTYLAQRLAGLMPNELGTQDLALLLSPRAHIAL
LRRRRAQMIVNRVRLMAFLFAILTPLWSIIDFLFFPLPLWSTLALMRLIAGGAFALLAFY
WRPDRRMADAYRALAMLFAIPGLFYLGTQEALIYYQLRGLSEAIKAGYAFLPFVLLAGIS
IFPLTLTESLLVALPLLFAQAFSGLFIGPMLEWPSFAGAFWLQVLITGVAILAGVSQLAF
MIALFRQAIRDPLTGTFSRRSGEELLERQFQIARRHQAPLSLAFLDIDHFKQINDRYGHD
AGDRVLIATAAAMIKRLRLADILVRWGGEEFVLIMPDTDPAEARQALTRLQEAGFGERPD
GSPLTASIGCAEVGQDRCEDWRTLVEAADRRMYLAKSGGRDRAVFTDQPAPPAAG
>A0A1J5RXW1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSKTTSTAQVTELARATLKRLAELHLGPTPDNYARIFNELAQAAGPPPPANGILPAAEAS
RASTGPDVCAAPVQAVAWGPLLLHLLGEWERSQAGLTQLQKRQSIEALGPASMPAIEAGE
LQQRLVRLLTQWAALPSRQAAGALADAPRPAEAPASEAIWRQLWAQSLKYGLLPTFTDAE
VVQRVQGLIALAEGGDAVADAAALNVQSRELWRLWDARHAEDLAVREGLVRLFDLMLDNL
GEFLAQDHWISVQMSAIQDILRPPLDVRRLEEAQGNLKQLLFRQGVLHKSADEARATAKE
LIGLVVRNLAAYAEHSAGYNQVLEADLHKLETSDDWEEMRGVVRGILEQGREMQQRSREL
GGQLELAQRQAAEAHERIQSLESELEQASQKLQEDPLTGALNRRGLDLVFTRDASRALRL
KLPLSVALLDLDHFKRINDNFGHDLGDAFLRALVDLTRRLMRPSDSIARMGGEEFMLVLP
DVDAEQAYPVVDRLLQAFCAQRILHRSSGQSVQASFSAGIAAWGQYEDFVSLYQRADAAL
LHAKQAGRQRLAYAAPAQAGGKPQPARPLV
>A0A1J5RAK9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTTPPPPREPGPPPAGEAELSATDQAESLLRTIPIGFAGSVLPAMLLAWELRERAPGALL
ATWFGAILVAHGLRLGVWYAARDELHAGRDGARWLRWLRLSVFALGLVWAMLPLLPARAS
AFDELLVAAVIAAVCGAGAAQQSSDATSSLLFMLPPALSSTMRLFLSGDATLQPIGALAL
LYYGYLALAGQRTESSFVGLSRLRARAAHQSLHDALTGLPNRLALNLRLHDALARARRAG
TQVAVGYIDLDGFKEVNDRHGHAAGDTLLRELAARWSAQQRASELIARLGGDEFVVVIEE
LDPAQAAAQLGAVFSRIHEAGTAPVALAGGASAQVGMTLGVARYPLDATEPDRLLRVADA
SMYQLKQHKATRDNWWQFGISDAADAPERELPPYGADAAAVLVEHAAWTARINADYAQTL
AHERRGDAGAGVEAAQATRHDALDDEQLEQLRLLVAPDTTREALQQGARQLGTLHCLAGV
SGSSLARASVTYRTMLADALGGARLSASRRWQLLRIIDARAHDALQAEFAAAEDVTQAYM
QTLSRPRPDAGTRWSDASQREIDFIAALPGIVAVALIRPDRAGELVVERSAAHDGEAQLS
ALFARGRLPSLDPQTRNGHSATADAWRTLQTQRVGDWAHDAQVATWRDAGVALHVRAEVA
VPFGGRDARAIGVLTLFGEQHGQFATSWMRQWAVGLQRRFEAIWTQCHAPPGAAVLSQEQ
ARALHGQLFGGGLEMHGQPIVALRGRRTVGIEALARLRMPDGQLLEPAAFLPSLGEVELD
RLFRLGLEQALAALSAADVDLSINLPASTLLGSDCTELIADALRRHGVAPRRLTLELMEA
QAFDSQAHGAAVERLRALGVQLAMDDLGTGYSSIERLADLHFDSIKIDQALIARLYDAPL
QTVTLTGTLVQLGAELGQSVVVEGVADPAMIEVAAVFGADQVQGYAICPPLPLPAMRDWV
ESHRDVADADGAGGPLRTYAGALAYHWRYVHMNSGHHPQTAETCALHAFLLAHGLADSEP
AAWHAAVHRADGDTDGASRRLLAWLAGEVSASRDAPRDTRT
>A0A1J5RHA4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MERTVEQIPARAPVRAQVRRAHGMFVTTSAVLCAGFTGSHGVLRGTFLVLAVVVPGAIVL
SLLVRRRVRHPLPWVVVLIGLVLLTVNSIAWLVQLDLEGRAVATGAVVTATLPLGYLCLL
VAASIVVSPFARLDAGGVLDAAIIGLGGASVLWTLIVRPPPPDNVAARAAGLGDLVVVVL
VTMIVGTVLRAFMTARSGALGYIGLCTGLTLVGTVARLVTRSPSGTSAWWVELVWIVAYT
ALGAAVLHPSRDDLPRAPRPAMRGGNSLSPARLVFLGVALALNPAFTVLMALGDRMVDLA
LLSVTSLALVPLVLARIAVLARRQASAEASLTHLATHDELTGLLNRRAALSQVDAALARV
DAGEASAALVVFLDVDGLKYVNDRYGHAAGDALLVAVAERLRSAVRTEDTVARIGGDEFV
VVSVGPPEVISLVPDRIDAALAHPVTWEHLTLAAQASGGTVIAHPGEFAGADEVLALADA
RMYQVKQHRRPEAAQPADADESTARGR
>A0A2N9LKI7|diguanylate cyclase|EC 2.7.7.65|Acidobacteriia bacterium SbA2|TrEMBL
MRQGAERAMSEIGVSAGEEVEYKELNDSGESPLISSRPSPTSEEARNAEALLALDMEAGS
DYLLELTVHNLRQLGQAPHQAFLQRLLRGLTSIEVSEKESIVHWERILGRRNELAEKLGR
QVFLRTAAVDYFGELHLLRKPILLEYEELEKLRHNAATDPLTGLKNRRTFEEHLGREINR
AARYGTSFGLLLLDLRRFKRANDRYGHAVGDEILRSVARASAETIRGSDVSCRIGGDEFA
ILLPQADRPSVEASAERIARKFESHAGPLAPETPVGVDYGIAIFPEDGEEAAKLFQAADK
NLYHGKRNAVRPVEQPAPAASGSPPEPGGAPHQPDGGPHTSGEGLAGRSDRLPDYTGAAE
NTQLPDGFQDRRRHERIPVEGARRLGLIRLPRRTKFVTVVDVSREGVGLLVDDFEVPETF
SALIHVPFLPDSELTLHRAYSCPVLNGKKRVGCSFTPLSEQAAA
>A0A1J5QT68|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTKSELADVWQLRAMEVAPVAIAVVDRQGLVVAVNRALTDMLGYEREELVGLEVEALVPT
EARDGHRDRRRAYAGAAKIRAMGHGLELQALHKDGASVPVEIGLSPVEVDGVELVMAVIV
DITERKRLQAAVAQSERRHRGVLDHAPDGFFMADADGCLIETNLAYQRMSGYTAEALRGM
CINDLNAFDRRADTRERIDAIVRTGAARFETWHRRQDGTTFPVEVAASVVPELGEIFVFV
RDISRRKKADAEREALAQRIHQFAFTDVLTGLPNRRLFMDRLAQALEAARRHGGLGAVLF
IDMDRFKALNDKLGHAAGDRFLVEVATRLRNSARLEDTVARLGGDEFVVILIGLDRQADV
AATHTRAHASKIAARLGEPYAIDNTVHLSSASIGATLFPLPGDTVDAVLHRADQAMYGVK
VVGGGGCRIEPESVQRLSNGCGGSQTPPSA
>A0A1J5S4S2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSDLLQKTPTRISHYPRWPVLSGVAGLAGIIGLLVLSLVNEYQDETQHARTEVENISQVL
DEHASAIVHKGDLLLREVQRNVRSEDMRPAHGVRGLRKQALHDLLKSQLDSAPEVSVIHI
ANAKGDYIYSSLDPIPEINIADRDYFNHQRASTTAGLLISSPLISRTTGKWTIVLSRRLN
YEDDSFAGLVSVILNLDYFQQFYRTLNLGPQGVVALYDQEFHLAARYPPNEDLMGKVVPV
SVGIYIEKGIKHGVYPTKSPVDGIERQISYRQLNDLPLFVFAGISEQDYLALWRRHIWQY
SAGAIVFGLVVISFGLRQRRSEMALRKSDDDLRTIADYTYDWEYWEGLQGELLYISPSCQ
RITGYSQAEFIADPHLIYDIIHAEDQPLMDAHRADIQHEDVGTLDFRILTKEGETRWIAH
GCREVYSKDGHFNGRRTSNRDITDRKALEEAELRERDFAESLIDTAQAIVILLDTEGRIV
RLNHYMEELSGYRLEEVKGASWFATFLPEQDIDAILGLFKKALTETHTQANINPILARDG
RKILVEWYDKTLKDSAGNIIGLLAIGQDVTLREKLAESQRLLKAAVEQSNSSIVVTDSDG
TIIFVNAGFAHTSGYLVDEAIGQNPRILKSGKMQKETYEEIWATIASGRHWSGELCNKKK
NGDLYWETANISPITDESGRITHYLAVKDDITRRKQAETALQEQKNFLSAILENEPECVM
VVSADEVVLQMNAAGFIMLEVNSVEEVNAVGLVNFVVPDHRAAFLNLARRVFDGESGVLE
FQVEGRKGARSWLETHATPLRDAAGKITFLLGVTRDVTRRREAEERLALSLKGSNQAMTD
WHIPSDTLTFGEGWMSLLGYQPDELRSNSSTLFELMRPEDAPAAHDALIRHLKGETSYLE
SEIRMRHKDGRWIWVLARGMAVERTSDGRVVRVAGTAMDITARKKAEAEIARLSQWNELL
LNSAGEGIYGVDHEGHCTFINPAALTILGFAKHELIGKSPHPMFHHHHTDGSPYHQEDCP
IFMTLRDGIRRKVEDAFIRKNGEAFPVQLTVTPMHDNGLLVGVEVVFQDIALRKKMEQEL
MRLATTDPLTGMANRRHFLEQLKMELAHFKRFGRPAAFLMVDIDHFKNVNDTYGHAVGDV
VLQHFGELSKLRLRRIDLIGRLGGEEFGILLPGTDLAGALQFAERFRIHVADTPAQSANG
TIPFTISIGISGFDQEDVEPDSILARADAALYLAKAGGRNQTKVN
>A0A1C6JMA3|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MRSEFKEHIRNIIGKLVEQSDSERDNKVCFFKHYSSFNIDEEDIINIMTSLNLECDMFYY
QFEEKKIQGPFCPFLDFIKELYQKYYKYMDCKEFVKKASVYPVIQDMLISYIMNGYCERN
EDIIPREVPFEREKIIESVINIFQYITNEHKVVIVLDRLQRAHESTIELLYGMMKNKELF
DIVIIASYNEAEDLYSYTKDSWNLLSRYIKDMEMSVDYNDDNKDAMADDVFIPVNTQIDV
YLKDIKDLFLCLQLEQAKYYLDIIYKAIENGNLEVEDAQKIDILAIYSFVTVYNGEEKMA
YLYCKKMSDIEYLRHDKERLIEYYYIAALVNLQSGQKNLAISSIEEGMKLTSDTNNNKYI
VKYEMLKILIDIDKLPEILLWNPKSGISEYLIEMARDNNQLLHLAYAYIFGFNISNKLKL
TGDKLANTELEECFKGIELAKELENTQIQIRAWQKTAVQASSEGKLDETIFCYNQCLKIM
EGHNSKHEEAQIYNGIGYICLINEKYKLAYDYFIKAINIGLTVDTPKYILDAVYNLGITS
IIVGDYASAVKNVNLTMKMMESLNLSRLNVCNKTKLYGLAIFAYIKLNQVYNAMLYYDIM
KTALKHILDVDNPDYNMWEDDMYLYYTVTAMLADKEGDYDKANEYYEKVQNFWYSIHVKQ
NYILPKVVEEEAIFYKKTGNEEARKKVLTDTIKFCKKNLLIHNAEILQAILDNKNDVKEP
DDNYEISNELIEEIDKMIIRCSMRKEIEKKNKMLSFFENWVDSLNYEFEKADDMINSSML
MIKNRFDIDSVMYISIRNGIPAVKYSDNEISVKKYQLRYICDYFSKNGRRIVLSRFKRSY
QYHEELVSAFNRNDVATMIAIPFINREKLTEIFVAFRFKKMNYTKGLFMFEESDADLLRT
AIKELIEALSKVSIKKELEKRSVTDTLTGLYNRQGMKEYINKVTRGFVSEKERHKFTILY
MDLDNFKYCNDHFGHEAGDAVLVAFSRMLEGIVESSGYIIRYGGDEFVIIIPDKDTEYGV
EIAEKIFANLRHNKGFKKVIEELKNMEVNISEKNRITCSIGISSGNVSGYSGIAMILKRA
DEALYYVKNNTKNDYKVWNLKSQEEK
>A0A2H6B6T0|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MSAAAVTVLARLAERTYQSFSEAAGQALDLLEESLPPGVVALGRFDEDERVYRVLDVRGA
TSEALARGTVLPMPREAPNPDVELLDALAIRSWLAVPLLASNGDALGALWALSTDENAYR
EEDWALVAVCARLLAAEWEGVQLRADLRRLREQLRDRDRTDHVTGLPNRQSFLEALEREW
RLCKRGAVESHMVVLKLPNRSEIEERYGEAMATLMLKDVAEALQAVARKTDHTGRLDDEL
MGVILVGCKGREGAEAFVSRLCSRIAHVARERPEVPHPVFGFSPLGGIEEPVAVLEAARA
DLETAAAALAAEREAELAS
>A0A6N3HUP8|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MGWYMRALFSPVRLFHHNQPLMNAAAIFFITTLFYFIGAQLRLVEELSLFWPLNAVMAGV
FARYAFLNHWRYYMVSYVAMILYDGVTTSWGVASLVINFSNMVFIVTLAWLVQREQRASR
TAPLPINALNLFGYCLIAALLCALCGASGSMGIVLNQDFLLLFGDWFSEQFSTGVLIVPC
VLTVAWPRVAVLTLRDLLPVVALAVSVMGSVVIGGAGSLAFPLPALIWCAVRFPLPVTCL
LTLVTGGVEIILVANSIINIFVASPQEMPRMFSARLGIATMAICPVIVSVSVQTINRLIQ
QVALRADFDFLTQVYSRSGLYEALNHDSKHFSRKHLSVMLLDVDYFKRVNDSYGHECGDS
VLKTFALQVRNVVGDDGVVARMGGEEFAVVAATSGPEEGYRLAERIRATIAEHPFVWQAQ
TLRLTVSIGVSHGQAQPRQLTEVFNKLLAGADEFLYQAKKAGRNCTRMGVDVERSAAPVV
F
>A0A708CPS0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A829ZFE2|diguanylate cyclase|EC 2.7.7.65|Lactobacillaceae bacterium|TrEMBL
MALKLFYAILYLPIIVICMIISQIYFERYWVSYKNSRLTSWGLGAVIIITYFIQEFCLFQ
LSLFNIGQVVFMQVVSVTMLFRDKVYKIWWALLALTPLFVNVVEYLMGILPLKDWWYWIV
ESIIFTTICLVLTRWRSISKRISYFYAIASLGIVELVSLGINHSFSPVSVAAATLGLFVI
AMFEEQRFYSEKKNEQKIKLLEKESERDDLTGLLNYRALSQEINRLANNSEIHNIVIGAL
DIDHFKKINDTYGHFVGNEVLNYFSTVFREQIHSAFPKHGYVYRFGGEEFTIVVSNHSLE
EVYQLLQSIEKFFNNKSIVTKEGMKLTISFSCSLTDRLNDELLDTTLKRADKMLYGVKNN
GRGWIVTDQHHQRPQKPSLERKINNNY
>A0A7U7EDS8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MPSPLDLLLNRLTTLLPSELKPNELRHLLTPGRHPLLLCQRRATLIVNRVRLFAFLFAVL
TPLWSLIDLMVFEPRLWLALAGLRMMACLAFTGLLLFYRPSGNLLDAYRAIAILFAIPTI
FYIASHTLLGSYQLAQFSAVVGAGYAFLPFVLMAGLTIFPLTLVENLVLASLLLLAQAFA
GYLSWATLNWPSFAGAFWLLILIAGVTSLASMSQLAFMFALVRQAIRDPLTGVFSRGSGE
EILRLQWDSAQRKDGALALAFIDLDHFKSINDNHGHEAGDQVLRCAARRLVTTLRASDSL
LRWGGEEFLLIMPDTDMQQAHLALERIVGQGLGLRPDGAPLTASIGLAERRCDQVGDYRD
LLELADKRMYYAKTGGRNRLCAMEPDAVLQRGALALSG
>A0A7W6E1C9|diguanylate cyclase|EC 2.7.7.65|Sulfitobacter undariae|TrEMBL
MQGKILIIDGISTNRIVLKVKLIAAFYQVIMASSIAEALQTIQNGMPDLIISAVNLPDGT
AAQLCKRLRSTPQTSSLPVLTIASSPDQQIRLETLRSGAFDVMNKPINETFLLSRVRNTI
RAHNELSDWDTPDAPNCALGLAEAPAKFVRPGKVCLVGADTAPLQRWLRELLPHWRAQYT
VTQLTHTLAQVHVRGPNATVPDAVVLELPQTKASAASCLRLISALRASPSTRDIALIIIQ
KTPDPLYAAEALDMGADDVMSAGFDAPELALRLEFLLRRKQQLAKVMQNVRSGLREVLHD
PLTGLYNRRHAMPFIAQEIERSATSSAPLALILADMDHFKQVNDLFGHTSGDAVLVETAR
RLERVLRSTDVLARIGGEEFVIAMPATDTSTARIVAHRVCDAISNAPFQIPGSQDPINIT
ISVGLAMAGQSVRPEARELETVESLLTRADNALYAAKVQGRNRVNLNLQEPHHLV
>A0A1C6CIB6|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNHKKKKTKNKILKLVCLLIFVIGTAVFLEAAILYTVNNKNVYQISKVLLDQAVDIIEKN
QKNEDDMIQSLKEDYIVRAKAVSYIIDAKPEAEKNITELKKIADLMSIDEIHIFDKKGKI
YSGTEPKYYGYSFDSGEQMAYFKPMLKNKKLTMCQDVTPNTSEGKKMMYALVWNEAGDRM
IQVGIEPVRLLQEVKQNEADAVVANMPVYKGMSLYVTDKKSGKIYGATDSKKIGKTLDDI
GLSRQRKKIAKENLVSGIVRVDGEKSLYIIKKTKKYIVGVTFEIASDNASNMIAILIMVV
YLSIAAGVILLVISRLSKVRKEKKEQSAMLSSISEMSNIDKMTGCFNRRSYEEDLSKMSA
NDQFIYISMDVNGLKIINDSHGHAAGDELICGAAACMRSCFDKYGKVYRIGGDEFVAVLF
VQLEQFLWIKTEFDGDIRYWTGNQVEEISISCGYVSSGERKWASMKEIANVADIRMYEEK
AMYYKKNGVDRQGQPASYVALYRLYSQILRINLQKDHYKILNWKETIHKNKQLPKGTLTE
WFDNFQDIQFIHPDDREEYQQKTDLEYLKQQFAEQKEFVTITYRVKEGTDYKTVTLEIVP
EDENSKNTYEGFLYVKDSKANLI
>A0A8F9I4G1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6N3QPR9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A212LUU5|diguanylate cyclase|EC 2.7.7.65|uncultured Sporomusa sp|TrEMBL
MPILDTYTIYFLIFMGNLVMCLMLLIFAKTTGFEVLMRYYTYAKLLQTSGAGVLLFRGIV
PVDFSVIVGNGLVFLGIALEVCCIVHIDRVPLKSVVKRWLQVAAGLAVGFALLYLAGANI
GIRAFISAMSIAVYSLVAAAGLFFRSNSTNLRRVVALFFLILAACQVIRALYAFSLGPNH
APFSLSLSQMFAFISLYLHMLISTMSFLLMSREVIDIRLQEAATKDFLTGIYNRAQFMQM
SEKLLSLMIRQQRPVTVFMIDCDNFKVINDTFGHAVGDSVLVNFSQDTQAILRKEDLFGR
YGGEEFIIFSPNTTDSDALIMGKKIQSAILLSAAGDLTIPKYTISIGTATMIPEELADME
KLIKQADQALLQAKRNGRNQIVQFNEP
>A0A090NFH9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LAFLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNT
>A0A090NYB9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTFLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSIPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPTTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSGWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A8B4SAI4|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MKKSLPWQRRLAPTRLDLRRLILVLTICSALIPFLNTFYAGYLVQRQQLIDNTLEGHHAY
ATKLAQSTDDFLQSALQQLEYSANLMGAHMNDVDYLAKEATRLRLQTKSFNSVTIIDPTG
YVLATSPETLQIKGKTLQSAGVTQTLSTRGPVISQPYMSMAGNYIVFVSQPIFDPQGEFL
GAVGGSIYLKEDSILDTLLGSHFYQDGTYVYVVDQNRHIIYHPDNHRIGDQVINNDVINS
VIRGESGTAPVVNSKGVEMLAGYAVIHASGWGIVAQRPKAATLAPLNKLMRSVLYKTLPI
ALLMLVVIWWSARRIASPLRQLANGAHDMDKPETAQNIQAVKSWYFESYELKKAMLKGLG
LLQRNITKLREDVNTDPLTGLGNRRHLEAAIGAFQAQALPFSVIAIDIDHFKHINDGFGH
DTGDEVLKQLARTMREVSRVDDLPCRVGGEEFLLLLPGTVLEAAAHVAERLRQMVEKMEI
QPVGHITISLGVAHWPDSDPDIKAVFQQADVMLYAAKRGGRNRVMVSEASEPPSEL
>A0A6N3FUI0|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MKELHRKSLYHYATALFVFLCYLGMCIAVFFYGIQHAVEGTTRAQLAENVTKQCDHLKDV
IGLEFENLEGVAAYLGGQENPVKMENGDLLRAMVSESAFVRMTYGTKDGTGYASDLPELQ
DMSGQAFFKEAMKGSRVVSDPIESPLDGTDLIVLAVPVYDSSGGVTGVLAGSFDVSRLSE
IFFGDLYGGAGYVYIINSAGESIMMDKKHGEARRGKTFFAFYSDVTFEKGDSLAQVQADL
AAGTGAVRRVRRDEDIRYLTYEPVGYNNWFVCYVVPEKNAQQAYAFIRDYEIVLSLFVVA
GLIILLAVLQYTNVRDRRLLEVKAQTDAMTGLLNAVSTRENVDVWLKNGECRGMQALIML
DVDRFKDVNDTYGHAVGDEALRQSAALLKRHFRGSDIVGRVGGDEFIVFMKNIPGGTIVS
SQLEKLCQAFHAIRIAEAQDLRLTCSAGAALAPADGGDFDTLYKKADLALYSVKRGARDG
FAIYKDSGS
>A0A6N2Z9T6|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MKKHTIQIWSMGLALCLVFCLTTSRVQAEEKKIIRVAFPEQTGFSSTDSAGNHSGYTYEF
LEEIAKYTGWEYEFITGDSSDESLLKMMEDLKNGRIDIMGGMVYTPQLAEDYDFPEYNCG
YSYSTLSVLKDNEDVNATNYSTFNNMKVGARKTATRRIQALNEFCRANGITLSIVEYDSD
EAMQAALKSGGVDALLGPDVAMGDDERIVARFDGRPYYFAVTKGNTEVVSGINTATAAIN
EQNPNYATELYMKYFNKNNQQVTLESFIKANPTESIVAALGIGLVLAAVVGMTMYIRMQR
NQQMLLNYERYRILSEMSKEFIFEYDYREDSIVVSEQFAHTFGGKSQVDHFFSTILSKRL
DIDESARCFAGLIKRRPPEEARYEVEYKTTVPSGNEEWVRATSMIIFDKHNQPMRAIGKI
ININAEQCEKEALINQAHRDALTGLYNRTTFEELVNTYLQERGDEEGAMMVVDLDHFKTV
NDTLGHQGGDEVLEDLAREMTACFGEEAVLGRLGGDEFLVFVKDVKACRDKPVQAARALC
RAMNRCYERNSGQIEVSVSVGLAYSFRNSAFEMLYSMADEALYYMKDHGKNNVKVYDASI
GDALGNNDNNTRKGAF
>A0A8B4S999|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MLVDVSAALVEGEKMILREFVVPASLVPMSDTTFFTASQYENICNGLPDPTFILTASGRY
AAVLGGKDQRYYHDGTSLVGQSIADVLAPAKAQWFIQQIQEALSSQKMQVVEYELSAHDV
LGLPLEGPAEAIWFEGRVSALGELFWGERAVVWVASNITASKRMQQQLQEQALNDELTGL
CNRRGFMRELAQAYTAHRLQGRPAWLMSFDVDHFKAINDGLGHPAGDQALRDLAAAVRWL
LAPEDVFCRLGGDEFAILCCDRHIAQVSGLARQLLEAGQQALQRYATGSPVPALSVGIAH
FMPTDSSLEDIMRRADQALYSAKLQGGHRAVVADRGPADHCIA
>A0A5I5T3C1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Isangi|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYKTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>V0AL92|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 909945-2|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFNPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQACHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A0F7KWV1|diguanylate cyclase|EC 2.7.7.65|Croceibacterium atlanticum|TrEMBL
MGMFIRSPSLAARRPLGNWLRTGASAPITDNVGMGGRPDPKHQLLEQISAFLIDNDLEVN
PANLATAFHVASGGKPRLAFQVAQLSAHGGITQAWLDAHPDHESEVHEAEMSRRLMSELD
EVLTQFSRQATAARSAASDYSSDLQRHACELKEMDGGTDNLVGRLVSLTQRMAERTRAIE
GELSSREKEARKLRRQMGQMKRDAEQDHLTGLPNRRAFEVQFTAACEKARENDEALSLAF
CDIDHFKRVNDTHGHDAGDRVLKMVAKVLSRISNERCHVARHGGEEFVMLFRGKDVLQSK
DALDQARETLGALRLINRDTNEPIGHITFSAGVADVFADEDPRKALRSADEALYKAKHSG
RNQVLVAGADEQENPAEKL
>A0A423S7L0|diguanylate cyclase|EC 2.7.7.65|Pusillimonas sp. NJUB218|TrEMBL
MLLDIFRREWALFNDFAGPGVPERVERIVTQQADSLASQFYDTMLKDPQAQQFLDHEQVR
TRLRASLILWLTRLFGPVSAEAADDLYADQHKIGEVHARVDIPVALVLRGARSLKRAFNA
YLDRVAPDDDAFKLSACRFFGAKIDLAMEVMSQAYASSSARKARSSEAYRLFSITENLAT
EKERQKAALLDWESQVMYETVLGNASTRLVRVRESEFGLWFRHKGIHAFQGVPEADVITQ
SIDAIDNVCLVALETEGAVDAQGRGDIVREIRNHARNIQLHLGSLFARSLELESGKDVLT
RLLNRKFLPTVLAREIEHSRKSGSGFAVALIDIDHFKRINDNHGHEAGDQVIQQVAAVLS
EHCRGGDFLFRMGGEEFLLVLVDLDAQQASLLCDRVRQAVQKHPFLIPDGTVLAVTVSIG
LASHTGHPDYHYLLRQADEAVYEAKAKGRNRVATHAGGSGVA
>A0A8F8CCB3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MRNKGGKGLSLARRLYTSRTLGLVLGLLCVSVAMYPLDPPPWVWALMLFNGLVWPHLAFQ
WARRSSVPYHAEHRNLLIDAFMGGFWVAAMQFNPLPSATTVSMMAMNNVAIGGLRFLAAG
LAAQVLGIGVGLVVFAPAFIPPTSPLQLYACLPLLMLYPLALGWICFRQAYTLGLHKREL
LALSRTDSLTGLLNHGAWKDQLDIAFQRCRRQQQGAAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKMLKQNLRAADIAGRYGGDEFCVILPDLPLFNAAQAMEALRERFATLGYEQNPA
LKVSLSIGLAAYDPAHGDATRWLNDADQALYEAKATGRNRVICNNDDLPKQELLDSV
>A0A8F8CA90|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MSLHPVRPKILGFISEDVSAWLVAILVLLAGGILTGLLAWATLNQFHHQLRQRFQLLANE
RYSRIEERFQDQEQRLDGLRRFFANSDSVSRSEFDGYAKPLLLRTQAYSYAPRVSRAERP
AIEQAVRSEGFSTFTFRELNADGQLQTAGDRPEYVPVIYTQSQSRLPTPLGYDLLAQPLR
RATLERADRSGHMAVSQPLHLVGIDPAYARGVLLLAPVTEEGAAKGSAQGYVMAVISMQQ
LLADGLPEETQDFLTVRILDLSTDDQHEVLYESANKAGASDLSATRLVRMADHDYQVDIQ
PSEAFLQANHSSISSLVVLGALLSLLLSALLYVLVSQRQRALRMVELRTQELHAREQELR
GTHGQLRGVLNAATQVAIIATDLRGVINTFNPGAEQMLGYSSTDVVGHMTLENLHLPREL
AARSAELSARYGKSIPTCHAMLVEGGEVGGHEAREWTLVRSDGSYLPVNMLATPVLDEQG
LWVGHLAICIDITERKRVHEALAARDVLLKKLSAHVPGGIYQFKMEFDGRFSVIYASDGI
REIYELEPDVLLLNAEAIFTRIHPQDVSRVRSSIRASADSLSPWREEYRVQLPERGLRWV
RGEATPEELPGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLTTEMA
RVERGGGELSVIMLDIDHFKRINDQYGHAVGDRVLQAVCERIGHRLRRTDVFCRLGGEEF
MVLCPDIDGEHAYKLAVELWQGLRSAPVDVVGVVTASFGIASWRPGEGADALLLRADSGV
YAAKQGGRDRVEQMS
>A0A8F8GCB3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MKLFRSGSRPTLGSVIGRGHLIVALVAVTMASVSLTLLGVLALRVYADHNLQLIARSISY
TVEAAVVFNDKAAATEALALIASTEEVADAQVFDAQGQVLARWQRPENGLFTELEMQITR
TVLEKPVRLPIVHQEREIGHILLVGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RGITGPLRSLAAVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKLNERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRIRAQLREEDLVARLGGDEFAVLLAPLHKIEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVFPDHGATPGALLNAADAAMYQAKRLSRGAQFTAGSESPVVNLQT
RS
>A0A1C5R1V2|diguanylate cyclase|EC 2.7.7.65|uncultured Faecalibacterium sp|TrEMBL
MKKECTEQDLRELARSAQAVFEAVTLTEAPLCDGWQDDGLRVDYELRNGRVDCVLHRRVE
ADGKCWELEMCAPLAGNVLPEERMTPRERELCREDMSHDFLTGVYNRRYLETVFAQKLEQ
CAAQGRKAAVALVSIDNGQKLRDTYGQPVMDQLHCFVGNQWKKSFDTPAVRVVCRLTGSI
FAVGCLDADGKQLAEEMQNLYRQMPRECITTTGMMRRVPFTLSCGVASLEDVPAKNWQAL
YELCDARLREAQNAGGDQMRAE
>A0A098GDT0|diguanylate cyclase|EC 2.7.7.65|Tatlockia micdadei|TrEMBL
MDLNSLKKVAFFSKHKDGNSSLANKILADQIRLFYKQNSFGIIIHFLAAIFLAVSLWNVS
ANYLVISWLFYMFLVYTSWYVITHYYRQNQNLATKYIWFWLLAFFAFIAGVGWGFAGSVL
VPANNLLHQTFVLIIIFAITAGSIPFFSPITFIYALFLFPTIIPFVAWLFFQGGVYILLG
LCGLIYIPIIFACCYFVNKFLINTLTLRYKNINLDTLNQLLEERVSNRANELERALAITK
STLESTADGILVIDLKGHVEYYNQKFLDMWQIPQIFITNPNLQFFISEALKQIKSPNEFL
KILEENTSSPSHEIFDEIIIDENRVFEWYSKPHWMRNIIVGRTWSFRDITLRKQMERQLA
FQATHDLLTGLPNRTLLFDRINQGIAYAKRYQTKLFLLFLDIDNFKLINDNLGHNIGDIL
LKEVAKRLTQNTRESDTVARFGGDEFIILFITNKYSDVIKLTQKMLDTVTRPMQLSHQEI
VVTASIGVSLYPKDGTDAANLLKNADIAMYLAKNQGRNNYRLYDQSMKRHTEKSLAMQIE
LRNALANNEFFLLYQPIIDLKSGQIVGVEALVRWKHPRKGVIHPLQFIPIAEESRIIVPL
GEWIFRNACLQNKDWQNRGLKQIYVAINVSGVQLTRENFVDQIELALDESKLDPKYVEIE
LTETTIMDNRKQNLQTLQQLNKIGINLAIDDFGTGYSSLNYLRAFPISKLKIDQSFVQNC
IHDYSDASLVEAIIAMGHGLKLKVLAEGIETVEQLRLLNQCACDEGQGFLYGQPMSAKAF
AKLLSSNLQYDHEN
>A0A2S6Q4G4|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MNREMVKVWGISIFSVVVLWSIASIIAGVAAKVLGANAIIYTCCVFIGSSFSLLLYSGSG
DLGRETLRSIETWSYGLLLIIAFICSFNIFSYATATEVTLVQRSSIVASAFLSWVFLARK
QSLVQILGILLVLMGIVIVCYNAPTQVKAYLSILVIIFAFLQAIRTLIAESHKTYNYAEN
NRTTKDKIRVVGYIMFVVSSMFLVVSFLFSLIEYSTGTNVSNIIPDLREFTNPASIFIGL
FAGIVIFAPIRLVEFTAASKIKAENYLALGALGPFATLFWEWSTSQYTGLSLKDFSQNDL
IATSILTLGGLIIAFSKAKKQIADDVNEYVSHTISDLQLVEDSKDVIEKSLTYFNKDLTK
TSKELKLPEKVLKAVLETENVALKKEFFDKVSRAYRTEISVKDSLTGILNRSGLMQQLDL
LKSKNKDFTLFYIDLNKFKPINDNYGHQAGDEALQIIAQRLSSLHKNIKIVSRLGGDEFV
VILQKDLDLVDFTSKLHKKIEEFFTVECVNMVISVSASIGYVKSKDYKNLNTEELLELAD
KIMLDLKESNER
>A0A7H4MQK2|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPLT
GLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLTEVASRLMA
FAGKRHLAWRLGRR
>A0A7R6V7U1|diguanylate cyclase|EC 2.7.7.65|Nitratiruptor sp. YY08-10|TrEMBL
MENQKKCQILEKLQHDIRLTKEDLKEIGFIVKKVVSFMVKNDILMTPENYARWFELFCYV
QENDLTLSDSEILQYYKQLFQKTPKKVHEIEDEEIRIKLKKIASGLEEKLSQIISTIDTH
NNTLQDRTEALQEKENQAADPQIVQYLKEILQNVEELRKENSKLNDQLKKYYEEINHLRR
ELRDTKNKAEFDYLTELFNRRKFEEYFQKLLQEFNETDGKPFSLIILDIDNFKKINDTYG
HLLGDEVLKNLSSLIKTFLHSAHIPARIGGEEFAILLPETSLDEAKIIAERLRKTVENRT
IPIAEGDLNFTVSIGVAQVQKGDTMDSLIQRADEALYAAKRNGKNMVIAK
>A0A5H8RY28|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durham|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7H4MQK1|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNKDFSQTARPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHEPLANKEQVSGLIS
QWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILGTDRQHSARLIHRPAADPLP
APGDRHRPAEHYRGCARYS
>A0A7H4SER1|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQ
QQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLTAVARREDIVGRLGGDEFLIVVA
PKSPRRSRRMSRSCARPCAASTFSANSVSTMKAPASG
>A0A7H4MLD8|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MYSSHSPWLSVNFIDDLRHTFTPLWQSIIGWLLMAIWFITLILLISLSKLRNIFWFSGAF
FCSAYLYTLFQLVSTAGTSIRPGTGAFFRNALYLFLILVLLVDVFMLYRESNHKYVNSYQ
NSIRDPLTRLYNRSFFYDTLNQQLAKVNPQHPLSVIISDLDHFKRINDNYGHVAGDKVIQ
FAASVLENHSRADDAAARIGGEEFALLLVNTAEKDALAIAERIRLAVNAEQHPLPERMTI
SMGLYTTRDRSVSAETCVERADAAMYEAKNSGRNRVVVWRHPGD
>A0A1A7R8X6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter gandensis|TrEMBL
MNQECITGLCQTWKNICEQYTAKEHQAAFKFIEEHVEYLVTVFYQQMVKEPESAEFFKDD
IIQKRLIDTLRKWLLETFQVAMNTHYEQSVKRQQKVGVVHARVGIPSWLIMRGVREIERN
VFEILEQKSEQQNLHMCSYIVQIMGFSTEIMCRSYEANTEKSQEIKHNYRLFSAMQDVAV
HKDKQRGSLLDWENELMFKIFSGSLGFYHPLFSKSEFGLWFIHKASYAFSGSEQVQLIID
RIYQVDELTQQAMQMMDRDQLQQVIQNIRELNREIQHLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIVSREISFARQNHTPLSLLAFDADYFKSINDKFGHAAGDMALKFIAEALQRFS
QGSDYAFRIGGEEFLLLLVDTEIDRAMSIAENVRRYIEQGLIRTAQGQQFNFTVSVGCVL
YDGHPDYQRFLDAADHALYAAKNNGRNCIYVAKTDPQATCSAS
>W9V192|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MSRAISLEEENKELRRMLTIMRQKAYHNDQLLHSFFEAKLKLMSSTTLAELVSYLLNDFR
RDFKLSSLTLMLLDPEDIVRDLLQGYEVNSTESELHLLKSQGPLNELFPDLTYFCGEPSE
TIRTFCFPHTVTIQSCVLLPLIQDNCLIGSLNLGSHDQLRYSQFLSYDYVMYLASVLSTC
VEICISRETLVRLSSIDSLTTTANRRSFNEHLSREINRCQRSNEPFVCMMLDIDHFKSIN
DRFGHLSGDQVLRAVAHLLKEKRRILDCVARYGGEEFALLLPSCSLDTGLRLAEELRRTI
SETPFYGQEGESIQVTCSIGLTVCDPKHPQYYRDVEKLKSNLISSADQALYRSKHNGRNC
VHHQPCPMLISP
>A0A6N2V814|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKQRQHTDIYKKTRKQLEQENCALQTLAELDGLTGLYNRITMERRVDDHLRSKQPGTMIV
LDLDHFKQVNDRYGHIAGDMLLCTIANVLKKMFSGRNLVGRVGGDEFVIFIPSVLDDSMT
AGECLRIQERFREVRLGDSILIKLSITIDSSDSRTCSRYRDMFDCADQKIMAKKRLRNLK
DGNGLISPAREPAGIQPDMSLIAREMEEKETQPGAYCQDYDTFKQIFRLEERRLRRDKKR
AFIILFTLTDRNNGFLPLDKRDTEMDILGEKIKQSLRMGDVYTRYSSCQYLVMVLDVSIE
NVDVIASRICSAYYQMHQETADNLVLHHSYPLKPARGRPRASRPQ
>A0A379IP27|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MAAVMDDQGNAVSELEELTLALLHSRAEVERLGEREQLFSSLLGSVNAVLWAFDWNEQRM
IYVSPAYERIFGRSAALLLADYGEWRNSIYPDDLDYAAESLAKVLETGAVESREYRIIRA
DGQLRWLSDKCFVSPRPGAEPGRVIVGIAEDITEKKRLEGELHRLATTDVLTQSSNRRHF
FECARREFEHARKFGSPLAFLLLDLDDFKKINDQYGHQIGDEVLRRLAQCGSNALRRGDL
FGRIGGEEFAALFPGCEQDVALQVAERLQREVQRLSFQHEGSSFGITVSQGLTSLLATDV
SLDALYARADASMYLAKRQGKNQIVLG
>A0A3S4STS7|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MAGEIIKQRYYFLTPLSFLLGILVLVATLLLAVASYLRSIDKTVAGYGHMISSIEAALLH
ELVLANRRQLAVLEASLDKAAIARGEPADNPLWAIAHQIKRDSHYIHFYSVRSDRISSYP
RLDLPAAYRADQRPWYKVLSMPGDELVWFGPYAEFGTQQRILTLIKRVRDADGSLLGLLM
VDMSFNSIQQALRRAMGENQATIYLSQRGSGRLVVGHNLALLPSGLSTKPEPDGIGLDVI
RQGRQLRLELADIDWDLNIYLPPALFHDSLYEALLLVVLPLSLMLATWFCSIHFLVRIFR
QEQALVAGSLDGIVRDPLKVRRPARRKPWFVHGSLGEIDMVRASLLEGQDALLHDPLTGI
MNRRAFDQHRLRLEQEQIPHWLVLLDLDCFKQINDNWGHGVGDSVLCRVANTLAAELGEG
RVYRIGGDEFAALLPWEQSELAQRLTTLLVRVRALQWREFMGPVTLSAGGAHYPQEQGTL
FERADEQLYRSKRQGRDCWHLSPTQSAPKGEVVTVSV
>A0A7Y9VYV8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas moraviensis|TrEMBL
MNLAQNIMENQRGKGLSFARRIYLPRAIGLGIGFFSVGAALYPLSMPGWLWALLLFNGFF
WPHVAYQWSTRSAFPYRAERRNLLYDSVFGGFWTACFQFNPLTAVTILSMMTMNNVAAGG
RRLFLLGALAQMIGVLLGWSVFGVNFTLTATQTQVWACLPMLTLYPLALGMVCYRLAIKL
AEHKRTLSALSRTDSLTGLLNHGAWKDLLHLKFQQCRQHNSQAILALIDIDHFKSINDSY
GHIVGDAVLRQLSRELKFVLDESELAGRYGGDEFCVILPNLPLNKAEALMEQLREGMDRY
RHPDVPELRVSLSIGLARYQSVYADALEWFDDSDKALYSAKHGGRNTISVALNRSTA
>F5NUA5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVD
GLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRS
KKDGRNRTSTMRYGEEVV
>A0A8B3WJF5|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MRFSLLLILMCWSFFTSAQTKDVLVIHSYHQGFFWTDSFQKGLAEELDRTRLSYRVVYLD
SKRTQNAEYLERVYQLYRTKLMHEDFAAVVVSDNNALNLMKRLAPQLKGTPVIFGGINNF
SPGMIEGLNATGVTEDTDMASNIELIKRLQTSVKRIHVVTDHSVTGEAVRNQIDIFLENN
PEMSGVVKHYTPDTYQELIAFTQKAKPGNGLLFWVYFRDINGRVTSNEDWRELNKKSQIP
IYMVNDLGLGHGAIGGVIQGGKIQGREAGSILLEVLDNPSAPLRAVVPGAAEIKLDYQQI
SRWNLGAENEASVTFLNKPKPFWVRYHDEIRTIGLLFLSMLCVIVTLMYYLNRLQKSERT
SRQSQLLLESIFDQSLQFMGIIDKGGVLLSSNSKLHELLYNQGYKLGTPLQSHQHWEDSA
RQELKEYFISSDEHQILRFEAEVWCRDRGAMVLDISLKPMPGSEEDDVQFLFEARDVTSG
KLAENKLFQREANLKLYYDKQPVMMITLDGNNRIQQVNQFAEQLLGYPLDQLLGHRPREF
YVDENSMIPRHILLQPQHKIRGVWRRDIEYRHANGSTIWIRENIRPLVESDQLLIVGEDI
TETRELSEKLEYQARYDLLTDTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLN
DTAGHEAGDAAIMFSAKLLEEVLPYNAVLARMGGDEFAVLMKDCTERDAVNVCRSIILTM
SENPFLWGDIRLNLTSSIGIRLIDHTAASPQMVHAQADAACHAAKEEGRNRYNLYHQDDE
DLRRRHLEMECVNLVHEALANDRLELFAQRILGLDKNSEKMHFEILVRIKNIHGEYISPG
IFMPASERYNIAHLIDRRVVSQTLAWLEHRPKVIDELGMCSINLSGHSMGNREFVEFLIE
SLRDSSIPCHKICLEITETAAMSNMKQAIKFFTRIKELGCMIALDDFGSGLSSFGYLKKL
PVDIVKIDGLFVRDIAVNEMDHVMVRSINDLAKQMGKHTVAEFVENTQIIDKLIELGVNY
AQGYIIGRPKPLAELVEELQKERTLEYLD
>A0A143QLE1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MNTGWRYSPTPVARTSGVNCLVSGLVGVVTVVGASPRAATVLLVLAVAWCALGIYMVAAA
PVLSRRLYLAMHLSGLTSIALFCTAAGGAIPAMSGIFLQLLLVTPAFIVLPNRIAWRTTV
LNAVYVAYLGAVVGGIHPVLVINAQLVLVAVAISAAWVQSVASTSEIDHLTQLANRRRLT
RELDARPGTVGSGKIDAIAVVDIDYFKVINDDHGHAAGDHALQTVSSALRHCLPRQYLLS
RSGGDEFTVLCTSGLATELRDAVDRVRRELPADLTISVGVAGRQGSESARTTLERADRAL
YESKNQGRNRTTIHD
>A0A2G4ATA7|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MESNQLFFRTIVNASYDIVDTTVNEAIKTYLKGITDTVASHVWHATPEQEIEQVSQIASE
LHIGQSGYIYLMSPQGVHLYHPFLQGKKRGHLTHIQKQLSIDSGMIEYFHANPHEISRRA
KVAYSMRLPSGNTLVATTYKEELMYLVDLEGLKDKLRKYAFGDSGYVYIIDLQGNLVLHP
DYEHKSLKALIGYSSELLIDRIATQPEGHFSYSISSDNGTTNKNVFYKFYPYLNWVISAG
ILEQELNRNHSLLFISLMALVVSLLSIIIVLVLYLRHRHLKILDVASLDYLTGLPSRRSF
IEQLKLKIAQRSPYPLTNVGVILLDIDHFKRVNDQYGHAQGDRVICEVAKSLKRFVNRRR
LIARYGGEEFILVTFDCDERELFELSEELRRSVEQLQGLVSPVTISAGCCHARALTDIET
AIDKADKALYQAKERGRNNTQTYQKNEYRVAYM
>A0A6N3I374|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEKKRAGSDRRSQSAVMYLVMAFSFCIFIWLLGTVKAPDVRFDSEKPVVITGDWSMEYQG
ETAVSQLPGPFSPKKGIPVRYSIMLGEYGTRGNSVMVRAVHQYVRIFLDGEMIEEFGYGQ
KTPFGEAPYNAWVIARLPDDCQGKTLSIEIENYYSGLSGQLNQVYIGTKNALVFQIIHEC
MPTMIFNFAIILAALLLLAYSFSFKKQYVTYQLRCLCLFSLVTCMWLVLESGGYQILWGR
APLVSNMLFLLFYLIPPTCIRFILTYDSFSKDKWLNLLYWLSCINVVVVSVLQIAGIRDF
IESLMGAHVLLILIMAELLFQFIWRILHGDKVRDIQLMAACLSFAVFACLDIVRFYVCSS
EISSAYFSQIGVVIFFCILVYYAVRQIVEEREEGVKRELLERMAYTDLLTGLPNRNAFEK
RMEALRGSGISGTMVVVADLNDLKRINDQRGHQKGDAALIFVADALKASFQDKEELYRIG
GDEFCALSGRITGKELEDFAASLQKKLEEGETKLGFPVSVAVGWSREDECGIDLAFRRAD
FTMYEKKQQMKREREQDETRLEPSECGCGGIKNETE
>A0A549ZWZ9|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MADQATILLVDDTRTNIQLLAGCLKSQYRLKIAMGGQRCIELAQNPPLPDLILLDVIMPE
MDGYQVCRQLKANPITKHIPIIFVTGRDSDEDEEFGLQLGAVDYITKPIRPAIVTARVST
QIQLKHQSDELRNMALHDQLTQLYNRHFLIESANNKLAHVERHGNELSVMMIDIDYFKHV
NDEYGHHAGDEVLKGIAEVFKQNSRKEDVVARFGGEEFVILLEHCPLDFAMEKAELLRAK
IEALKPSGITITASFGVAQLMEHELTFVDLLSRADAAVYKAKDQGRNQVVAAEVDVIGLE
LEKKIV
>A0A7S9J3H6|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MNKFSLLLVIAVTFISFGVTANNYNSQLDELEQSLLNKPELSKAKINKLVQLTADMTSEQ
IARLLTLRSIKLIFEGDYAKSIDLLSEAENRNPSHSLMNSIYLYKATSYISSKKYKLGLQ
EISKNLARIERIDDKEILSDTYQRLANLYLEVEAYDEMDYYAKLSIELSHNSNAKSYCYA
LLLVAVADLKLGALDEAKNSFNNSLDFCETNDIPLIAAMSTKGLGDVELKKNSFDDAKTF
LLSALNQYERFHFQIEINSIHALLSETYFGLNDNQQAYHYAELVMKLPYNPSNLEFKQIA
SKVLSKLSYQEKDFKQAYDYLSLQQALSKTLLDDTKAKANAYQMAKFENGEKNREINLLN
KDRELYTAKAALIQSQRNNERMMNTLIVGGLVLLGIFAGVMTLQRRKYKKLAQNDALTGI
LNRGTAQNIAEVSYIKSFSLGTSFSIVMFDLDLFKRINDEFGHGTGDWVLKKVSDEISKI
CPSSTIFARFGGEEFALFLPGTSESSALDFAEQCRAVISQIDTKYSGHTFKLSASFGVTC
SAEGDLSLDPMLHRADIAMYHSKEHGRNRVTRYSPEIEKCRAGYQKSRLALN
>A0A1V6FCY6|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin087|TrEMBL
MKWVEELQSKYDVNILYDVFLRENDSLYFLVEEGHKICDKPLLKLFGSCANVGLPHCVKT
LDELFSYIDVKSQICDIRGVKEYITELHREIDSDQTRVVLYLPLDFCGNKKYLELVIIKM
FKRNVSIVVLNQIDMKKVNVESLYFESYKDSLTGLFNFSTLMFHINKTTNNHYFGFIDLD
YFKIVNDTFGHKVGDDVLARVGRVLIEIADDTVIMYRKSGDEFIFMTLGLNFEETKKLVK
RIQNAIRSVELPNIKVNCSIGVAEYRHNNGHYSAHDAVNIADVAMYVSKSTGRGSVTYFK
EAEAKKIIDSGPLEKTLELLEARAR
>S5MXK2|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori N268-08|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQNQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDAAEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWGLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A379H809|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MMRFLLVFVLLTCAMPSWASITDYVVKQWNIKDGLPSQSLKSVVQDQQGYMWLGTQFGLS
RFDGNTFTNYNTQNSLFLPSNGINKLLIDGQGFLWIGTKNGLVVIDPATLSAQEFNIKGP
VRDILEDSKGGIWIAANGLYYVDRSLVDLRDQTNEPSPIVNPTVITQIVGSVSKMALAPE
GIWLVNDRHLLRLTKSAADFSKLRLELTAKVSLPDSLAQTIVHDLSFLNGNLYLASELGA
YFLDLDDELRSFPLPNVNNSAVYKFMSDTNGGLWVSTYGRLLFRGKSGDWQWVEPSQLDQ
SIWFADMFRDDQNNVWLASFSEGLWLAHEGRIERHSAISKMTETVMAISKSPDDKLWIAN
RSGVGYFDTNKNFINIINSSKYGHASVHDLQFDGDRLYIATGRGLFFYEDDTLYSFPGRA
LNDNPVFAISSATRGGFWIGTGRGLYRLNYSGLRPFAYNAFLGSKFITFVLDAPNFGIIG
TSKGAYYFTDRGIEKIGDQTTLESAYVTSILHIDGVGILVGSLNDGLFYRSGQGQWQQLD
AANGLPYGSIFSLKYDEKLKRIWVSTMKGVYRMPVDQFKTQIQSLKVEEVISSFDRQLDG
KASQCCNGLGHDAVVDMDNSIWYPSLQGVVEIPKSVELFGLRGLKPKIETLTTPLRSLTT
AALGNKPRLKIDERDVTLKYTAIDYYAPNSIEFRYKLNGLDTDWRYANTRREAIYTNLPA
GAFLFQLETKRQGEDWNIAQSVDYAFVVPERFDETIYFRLLITSGFVLLFYLVFWVFRAQ
ERRKQEVLEGLITDRTLELRQANDKLNKVNSQLKLVSHSDELTGLRSRRFLFDQLPKDIE
HFQRNSQSLQAQGKSLVLLIINLDNFSRINDAYGPIAGDSCLQQMAVLLNSRTQGSDYVA
RWSGDEFLLLLRDFKCNLIDSYVSDLCQGIAEHGFQLPNGKSTHISASIGWSFYPLPLLG
GQVISWETSINLADIALHQVKKRGGDGVANITFDEQLDAFEFEQNPNVEQQIGLLQANGL
ADIKVWMR
>A0A517Z5R3|diguanylate cyclase|EC 2.7.7.65|Maioricimonas rarisocia|TrEMBL
MSRRVLHRAILLAAAGTLVGGIAAILGRRLEHPEWATLTALPVVWGMSVLGGWRLALASI
LAVPVGWWLGRGESAGVAAGHFFAVTGVMAILATFVLMLERMRQVRDGWRIALQTDDLTG
LLNRRGFRERLEAELNRARRSGATLAVGLFDCDNFKEVNDTLGHPTGDLLLQCAAEVLTR
ESRNYDLVARVGGDEFAVAWPSVSASNAERIAQRVHSALSEAVERRKWPASFSFGVVVAT
GSVSVDDVIRQADEAMYEAKRDGKGRFTVRTVESGSDAAPQEDVSVPA
>A0A5E4X9H3|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MKSTISRTEQGNRVAATTILAACAALTLAGFLTRALEGAVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTQGVLLANQLAGISTHITRAPFWLWLVAEA
SFAAYVMISVRSYSRTRSDPHTRPGYSEAARYGATVLIIWLTVSLSVVGAARTLVTPKFA
GGIDVETIALGAMFVAYLALWWRIAAVTRLSHKLFLLVWVVVTISLCQLLLALTAPSEAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRIVADRVQQHNTPLSVLIIDIDFFKQVNDRYGHPFGDAVLQRIANTIQHCIRLPSDFVV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPLKAREDGEAITISVGIASWHP
GEPLVISSMLERADKALYQAKHKGRDQSVLGQLAA
>A0A5E4SVG3|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MIVRGIVILLCIVAAWGLARFAADQLVANRSARLLAEERSVATRLARGTVHTVNQDLILI
RGIPQVLAQIAQIQNAAAGIADHPLTELPHEVARERLLANPALKPVNDLLRAAQLYFGAD
LVWLGTPDGVTIASSDAREPNPLVGDNYGDRAYFQSAILGTAGQQYVIGRKTRLPGIYFT
APVYQEGRLVGAMVVKLGLRRLSHWVDTGASFITDVNGVIVLANDPTFTGLAVPDAPVFK
MTPAERRHLYQQEDFTIVPIENYDPSPGTPFFLMSNPSDEPGASQGANPGHEAHHAPEEA
DLVRVRPDNQPYLLESAPSMDSELVIYTMSEVPTLRSLFIERQRYTWLVFGLLLTSAGAL
FLLIRHLRRGKLQLSDTLAKNAALEHEVKYDALTGSLSRGHFLKRLRSEVHQANTTGVAA
CIILVDLDHFKQINDTWGHALGDTVLATFVRLCHDSLREEDICGRLGGEEFAIILSGATE
ARAFDAAERLREAVRAARINVDGRALQFTISAGVAQWHTGDDDNAWLQRADAALYLAKSR
GRDRCARESDLRVLTRGGS
>A0A5E4S0G6|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MTQPVANVMPESATLLEIVRAQTEIAKLGLDLGGVMSFVAERVQHLTQANGAVVELAEGD
DMVYRAASGVAANLLGMRLSRDGSLSGQCVKTGSILRCDDSETDARVDREACRRVGLRSM
IVTPLRHLDTTVGVLKVFAPTPSAFPDADVRTLELMSELIAAAMFHAARYETSQLYLQAT
HDALTGLPNRALFYDRLRQAIHLALRSSQRLGIFNIDMDGLKPINDRYGHRAGDAAIRTA
AERMHAAARRSDTVARVGGDEFGMILPGLHSREDAEAHRQRLTQKVGAPFEFEGNALELG
VSVGIAILPDDGTEMTQLMDRADEAMYAVKRTRPTTRG
>A0A2H6AJ15|diguanylate cyclase|EC 2.7.7.65|bacterium HR37|TrEMBL
MGGNKGDSLRKRFGIILANFISKNYTTTTVLVSSLGFIFPFLFVISLPFLSKSRFEVLAD
IFAVALISVLLGAIFTVCSLYILTLPVSSCLKVLYEYLTYGEVPKLYEIYCLNNKVNKEN
TLDGSLILSLLVTDYLTGVYNRRSAEVCLKKCVNSEQTPLLSLAMLDVDNLRFINNEYGH
SVGDICLRYVANVLKENIVGMDKNSWVGRWGGDEFLVMLCGLKEKESFEVMRRICSFFDE
NPVFVGNQLIGVSLSIGICEYDPKKDNEKNLLVKTDRALLEAKKRGKGQIICYSSLLPI
>A0A2J7VHM2|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. B4|TrEMBL
MVAALLFVQYQGSRVALRASVERHHARLTERTAAVFEDRLQALSELADGVAASLDEAALR
DKPRLQQRLAQLTLVAPHAFRTLSVTDLNGYPLAWVPATTGPQADASVADRSYFSGVLAT
QSRVIVGPVLSRSLRTHVTIFSSPIYGAEGKVVGVVVGSIENIALAATAGLGDFAGGPAS
LVTVASEEGTIIAQRNADRMGESVRTLGPMAKLFTEAEAPSGLVYGMNADGVPSLMYVTT
ISGPSSPWRLVMEAPVSKIFTDEAELRWHFLVVLSVGTALLPLLWLTIRAVLQPLRVLHR
QVAAVSLGNTVPAMDTSGLHTSDELELAEAVRTISRASTKSLSVEEAETTRLRTALHNVD
AGVLVVDCESRITTINQVAARLLGWRVSDALNRPLDQVYQPRLRASGETMPSLHPALLSA
KTALRRVNTLEAVSRDGKAVPLSEASVPVFLADGSTAGAVIVIRGPSAAEVPAVAGVHLR
DETTGLRRHCELQSVLTKLFNANGPADGHHAVITMDMAGCGDQGPNLGQLRNAGKAVRET
LRMGDRGFRWTEASLLLVLKNCDLPEAAFLAEDVLGKLRASDAQTAPQVSVGVLAFGPGP
ATWTEVVQAATRVTDAARRQPGAVYIAPESNGAGMLDALGDLFGQAPAA
>A0A5C6DYT2|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MLREFIASLRLAFALVCVGVSLILGAQWLGMLPDTERIQLQGRQSLCESIAINSSAHVRR
QQWVDLTTILRTQVERNEDLLSIGLRSEMGTLRLDTGHHAEMWPSDPELEPRVEIVKVPI
TLNRRPWGTVEFCFHKPETSKLAPLTEHSIYRLVGFFVLAGLASYTLFVAKIMGVFSKTQ
VVPDRVRQALDTLAEGLLVLDEKGRIVLANRAFADTVGMSSEELALQSASEMAWSLPTGS
EHPEVYPWMAAIENGELQSEQMLRYRLADGRNRIFSVNAAPLGGDDQQRGALATFRDVTH
VEEHREELERMLGMLRSSRDEIERKNGELEILATQDALTGCLNRRAFFERFEKLWREAKA
EESPLACIMIDNDHFKNVNDTYGHHVGDEVLRRVSKTIRDMHQHHGLVCRYGGEEFCVVL
PGLSLRQAITEAERTREAIASITFADPAELRLTASIGVSELRFNPVDTQELINQADACLY
VAKREGRNRVIAYNINMASEIENTSEQRMPKKAKRLEISYQAVTALMSALSYRDAKTAEH
SRRVADLCARASALTLDPAQIYLLEIAALLHDIGKVGVPDHILLKPGALTEQEWEVMARH
DRIGVEIVAGAFDCPELTAIISAHQLLGRSATDSAELPSDEHTLWCAKLLTICDSYDAMF
SDTVYRKGRSHEEAIAELRRCAGTQFDAELVELFASSIDNRTPTVTSGAFALGKQAAIQI
GQDVERLAEAIENQDLEGIAMHVLCLGKTADSCGIDSIVEAAAQIDAITKSEEVQWKALL
EETHEILDAARAAQSEFLRESLEIEKRLSFPD
>A0A3R9Q6H5|diguanylate cyclase|EC 2.7.7.65|Enterobacter huaxiensis|TrEMBL
MQRDTYVVKRSFQQWLHKRSNPGLVVNLCFIVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVANSLDRQLQFSVDKMLFFRNSMGDALQTPLAFGVLHDAARRFAALRATSNWQIAVDK
DRTLPLNGVSDAFVEKTTLLNRDDERLPNELSAALEVGYLLRLASSNTRKEERIIYVSRA
GFFLATDTPLHKQDISPRYYHLVVQPWFTQQSERSNRARAVRWFISPASIFAGNQPLITA
SVPIYYDHFWYGVVAMDFSFATMKRLLVDAMDDHVEGEYQLYDTRLNPIATSGSATSEIN
HFDERDMAQIAHALESDTQGGIRLGSRFVSWARLDHFDGVVLRVHTLHEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYALQHSLQWQAWHDPLTRLNNRGALFERAKILA
RQCRLQSLPFSVIQIDLDHFKGINDRYGHQTGDKVLSHAAGLIASALRTNDVAGRVGGEE
FCVVLPGLGLEEAAKVAERIRSRIDSKEILVKKSTTLRVSASLGVSSAQEKENYNFEQLQ
SIADVRLYEAKQGGRNRVVWRDHDRK
>A0A5Q2KDD0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MNKDFTSAPRPTFKRTLRRINMISVIVTMTFIWLLLSFASVVTLKEYAQKNLELTGATMS
HNLEASLVFNDSLAANETLTTLGKQGQFAAAEVLNVHEKRFAYWSWNPQDNSDTLGTLVS
RWLFPNPVSQPIMHNGSRIGEIRLTARDSLIGHFLWMSFAVLTGCILLASAVALTLTRSL
HHGMVIAMQNITDVVHDVRTNRNFSRRVKEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDASAKAHSALLFLDGDNFKYINDTWGHAA
GDGVLIDVAERMVEFGQKHHRSYRLGGDEFAMILYGVHSENEVQHICAALAQRFIRPFDV
HNGHTASMSLSIGYALAWENASVEALLEQADRNMYLVKNQRTKTLS
>K1KJB7|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MVENQQKIDQFKSDILSLCMNKKLQRSKFYDYFFLLEESLTKHFNMEHCFLFHVSENKLK
PIDNLELLNVDVALDLIQPYFNGNKVVKLPGFLKEQPYFENHTDVMPLIINDKIEAIIIF
KYNPVGAPIQTVLTEEIVGAISASYKYLIQKYEVYSNEQKYRKLYGMTDLFHSTMDIDVI
LENVLITIEENFPGLEVELILSNDQDRQTRVKIKPFDYLSERPATIESFVSGELKEDIAV
EQNRRLLNVPIKGRQAIYGILQVKAPINYSFANSEKEFIRMLAQASGNALENAKLYHQSH
RLITDLQLINETSHRLNMKLTISEMLLFLQKQMLKSFQPMEIGFMFKEDEKYIMTEACTD
LFDYVACNVYVQHVEKHFQTTQDPLFIADFSRLISGDIEYRSIMAIPMIVEEDIIGFSIV
LHKEPYFFSFDSFKLMQSLIHHSSLAISDSVLREQLQEMVDRDHLTKLYARSYSDSYVEN
SIQKDDSGMFLLIDIDNFKKVNDTYGHQVGDEVIVQIARRLQNEIGKKGICSRWGGEELA
IYIPNISDSEAIGISDSIVQMVPSVSNPSVTVSAGMITWHKSSRPNFKNMFAQADMALYH
AKRNGKNRLCVYEKPMELQY
>A0A5Q2K136|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MNKQYQRVLITTQHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMTVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWGSVSFIYTSVNIIEACIGALLLRKLLPWYNPLQN
LNDWVRLAIGSALIPPLTGGVLIHFLAPGPEPLRNFLVWVVSESIGALALVPLGLLFKPH
YLLRHRDPQLLLETLVTMAVTLVLSWAAMNWLPWPFTCVIVLLMWSAVRLPRVEAFLVFL
VTVMMVSLMMAQNPTPVATPNASAMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIDGQWLQANKALCNFLGYSQTELQSMTFQQLTWPEDLHSDI
EQLDQLVNGDINNYSLEKRYYTRDGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLQPDVISWDKRMFELYEIPPHIKPTWQLWNASIV
PEDRAHAEQVIRDSLKARMPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWPQSEAIGQPI
LNVLHITFGEKGPLMENIHSGDMSRSDIEQDVVLNCRNGGSFDIHYSITPLSTLDGQAIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFETHLKRLIQTVQETRQRHALIFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESAHYI
TGRLIHAINNYHFMWEGRLHRIGASAGITLIDETNHQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSARSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSNFWLISLRLWTSQ
GEVQEEQAFRSGLAEPELLHALDRRIFSEFFRAYAAQVAAKGMGVALPLSQAGLSSVTLV
DELIELLEKGPFPGRLLHLIISAEVLRNTDENLQQGLQKLRHAGCRVVLSQVGRDMSLFS
HLSANMADYLMLDPDVVSNVHGNLMDEMMVTIIQGHAQRLGMKTLAGPCNQPIMMDTLSG
IGIDFIYGDTIGEPQPLELLLNTSYFAIN
>A0A4R3ZL21|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. BIGb0138|TrEMBL
MSKRHEPIWSVALHNRRTLPVYGVSDAFVDGQSTLTRNDILTGNELMATLELGYLLLLAN
KNRGFHERMLYVSRSGFFTSTQPPNNATQAIGAPWFSRQTQRNNPGRGGVWQTVQQEEDT
QGDDPVVTASVPLDFQHDWLGVLAMNFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIAS
SSPGQVLTLLSPRERAMLSYAFLHDNRGGIHLFTRYISWEKLNNFDGVLLRIHTLQEGVR
GDFGTITIALTLMWLLFTLMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGAL
FDRAIATAGACERTKRPISVIQLDLDYFKKVNDLHGHQAGDRVLSLVASTIVSILRETDL
AGRVGGEEFCIVMPDTSLHAAAAIAERIRIRISSREILLCNDTSLRISASLGVSSSDDCA
EFNFESLQSVADHRLYLAKQNGRNWVCFKDPP
>A0A7W8SKV6|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. WSM4180|TrEMBL
MDTSKPPQNAATLHPADDVNPQAHALAGEDAPRLASDDALARILADPPAAECPITVLLVG
DQAVIAEGVREALADEPGIDFRYCASWEDAVRCAEETRATVILQDLVMPDGDGLTLVRQY
QLNPATRDIPIVVLSTDEEPLVKSAAFAAGSSDYLVKLPDRIELIARIRYHSRSYLHLLQ
RDEAYRALRQSQRQLLATNLELQRLTHLDGLTGLSNRRYLDQYLAAEWHRGTRDKTGLGL
LMIDVDHLKAYNDTYGHVAGDEVLKSVAHTIEACLGHSLDLAARFGGEEFAVVVPDTSAG
GLRLLAEKIRIAVEDRAITHAGSAEGVVTISIGAAMVVPSAAEPVTTLIEAAGVGLYRAK
RDGKNQVAVSG
>A0A6J4F2W9|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MGAVETIAHPLDQYRSLFENAVEGIYRTTPDGRYLAANPALARIYGYDSPGELIAGLTDI
ARHLYVNPADRDRFKEQLGTTSVVKAFEAQVYRKDGSVIWISENARAVRDPGGAIVCYEG
TVQDITERKLAEDRLRLAAAVFENVGEVIVVTDRDHVVQAVNPAFERMTGFAAEGVVGQR
FRILAQEINDADMVRDAWDTAMAGAIWQGELWARRSDGDVFPAAVALTGIADESGQVGSF
VMLCRDITRRKQDEERIRYHASHDTLTRLANRHTVLESLKDSILRADRAGTRMALLFLDV
NRFKDINDSFGHAAGDELLRQVARRLKGCVRATDIIGRLGGDEFVVALPDLKEHHSALNC
VDKILYAFSEPFALDEAREIYCSTSIGVAIYPEDSDTAEGLLTCADAAMYHAKSGGMPYR
FYDAEMNRQAVDRINLEIDLRRAVAEGQFRLHYQPKIDSVSGRIVGAEALIRWTHPERGP
VSPALFIPVAERAGLVGAIGDWALAEACRQMRAWTEAGLDFGCVSVNLSPAQFHDARLKT
KVEQALADNHLPASALELEITETMMATEVDRAITILSDLGQMGVRISIDDFGTGYSSLAY
LKLFPVHALKIDRAFVRELPGNSKDGAIVASVVALATNLGFELIAEGVETVAQADYLRTR
GVGTMQGFLYSPAIDAESFGRALSGEKSLG
>A0A752ITR2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 21:z4,z23:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A375EYD8|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLSALFDRLWEQAVRTPQRFVVLSFAAACALLLIISAYGLVVLRDHEVQTLQQTQQL
QVAGISSVLNVEAERLRGVRNFAQHLIRLQMGPHAVEVDPPLQAAYAHRNNDLWQLPAPE
GDAVLLGVGPRMLDGMDGFSRRDEDLLPGLYVARGLSHLLSAEPVNPLVTRKLMYVSTNG
FFVTYPPVPPARTAAVLRRVNDAGLMREHLPRNNPDRTLHWQMVPVGGDSGMYLTLSLPV
YLHAQFRGVAISAISQRSLDDYLTSTTRKGVHSFLIDIDGHLIGASTREVKGVEKIDSVV
PPAGREATPREMFSRGAGTIHLPDGSRLMFERIGGSNLMLVDYFSATDLLLRTASHLSVV
LAASALSLALLLWVTLQGFRKLFSHYLARGEALRELAETDPLTGLSNRRMFEARFAIEHN
HSLRENTPMSMMMVDIDRFKRINDNWGHASGDRVLKKLADVVRATVRSIDVPARIGGEEF
AVLLPRTSIAEATEAAERLRQVLGQVVCEPAADATDKGEIRFTVSIGVSDLGADGTDSLD
TMLMVADRRLYAAKNAGRNRVVSDDRVPEPMDDGTPAPARTASA
>A0A2X4UVQ1|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MPFVKNENGLFTKNESRKTLYMPLVLSGALCILVMIIHLAYFPAKEIGHSWIQNSGWLFD
LFQLLILNFILWSFNRLTVKASQRRWINVGLLVWILSAACDFMDEIIRQPQWLGYYIEDL
TRLIGMLCVAVGVYLIVHYVNDKYADASIDSYRDELTNLPNRRYFRRVLLDLQSVNYYVF
FIDIDLFKKINDKYGHDIGDEVLRAFGQMLGELSENNVIAARIGGEEFAVIVQTSVFEEA
QSTAEKILTRARELVVNDEVRLTVSMGAGNKRENESQESLLKRVDIALYQAKSWGRNRIE
WASSQEHGVPQACPENAVS
>A0A8F0CER8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3A3ZSJ5|diguanylate cyclase|EC 2.7.7.65|Enterobacter chuandaensis|TrEMBL
MQRGTFVVRRSFLQWLHKRSNPGLIVNLCFIVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQYSVDKMLLFRQSMRDALQTPLAFDVMHDAVSHFNAVRMRPTWQLFVDK
KRTLPINGVSDAFVEKTSLLNRDPEHISNEISAALEVGYLLRLAASNRHSESRVIYVSRA
GFYLSTDELTEASDIIPRYYHQVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERIITA
SVPIYFNRYWYGVVAMDFSLNTMQRLLAEATDDRTEGEYQLYDSRLNMIATSEKTDNQVN
HFDEREIAQIAQAIENDTGGGIRLGSRFISWQRLDHFDGLVLRVHTLQEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKILA
EKCHQQSLPFSVIQLDLDHFKSVNDQYGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARVIADSIRCRINSKEILVKKSTTLRISASLGVSSAQEKENYDFEQQQ
SVADARLYKAKQGGRNRVVWNDQDKK
>A0A238D824|diguanylate cyclase|EC 2.7.7.65|Thiomonas delicata|TrEMBL
MSKTTSTARVTELARATLKRLAELHLGPTPDNYARIFNELAQGAGSPPPAGGIPPAAEAS
RAATGPDVGPAPVQAVAWGPLLLHLLGEWERSQAGLTQLQKRQSIEVLGPASMPAIEAGE
LRQRLVRLLTQWAALPSRQAAGALADAPRPVETPAGEAIWRQLWAQSLKYGLLPTFTDAE
VVQRVQGLIALAEGGDAVADAAALNVQSRELWRLWDARHAEELAVREGLVRLFDLMLDNL
GEFLAQDHWISVQMSAIQDILRPPLDVRRLEEAQGNLKQLLFRQGVLHKSADEARATAKE
LIGLVVRNLAAYAEHSAGYNQALEADLRKLETSDDWEEMRGVVRGILEQGREMQQRSREL
GGQLELAQRQAAEAHERIQSLENELEQASQKLQEDPLTGALNRRGLDLVFTRDASRALRL
KLPLSVALLDLDHFKRINDNFGHDLGDAFLRALVDLTRRLMRPSDSIARMGGEEFMLVLP
DVDAEQAYPVVDRLLQAFCAQRILHRPSGQSVQASFSAGIAAWGQYEDFVSLYQRADAAL
LHAKQAGRQRLVYAAPAEAGGKSQPARPLAR
>A0A1C5YS83|diguanylate cyclase|EC 2.7.7.65|uncultured Butyricicoccus sp|TrEMBL
MNRYFAENSYLLDVQSEMQIGIWTIELLEDGTYVMYADHIMQKILSVDSTIPPRACYEEW
SNRIFMTHTELVHQEMQRAMAGEEVEVVYPWVSPEKGLIYVRVGARRDSMHSGNRIYGYC
HDITKKITSDERNSYFSRLYQNIIQTFGILYQGIYVVNYISRDVLPIRSALHCNISEHHM
LTVEKFISEMAEVFGAETAEEIKENIASYKLADSSQTKGKLYSKECCMKSGKEGAWFELI
ICRDAISDNENIILAFRDISTSKKQEVYTQSAMEQLKAQSNTDMLTGIHNRRFFEKRVNL
FLEDGCCSGAFLMLDLDNFKSVNDTFGHTQGDLLLMQTADILRHTCRNDDVVARFGGDEF
AIFLQNVSSEGVIHFCNRLMHRLRHTYDRDGKTITVSASIGVALCVQPGISFKELYRRAD
KALYCSKAAGKGRATFYEDEDCRHAERIG
>A0A1C6BJN8|diguanylate cyclase|EC 2.7.7.65|uncultured Butyricicoccus sp|TrEMBL
MNTTWETHKFEHYIFSLLLAVEVIMSFTFLGYMHIPPISITTAYIPIVIIACLFGPAESS
LAGLLFGLGSLYKASATYVMPADAVFSPFRSDFPIGSILLSVGTRVLFGFLLGCLFQLAR
KSKRKNLCKLLITIAAPKLHALLVYTAMGLLFPSLGFNILSIFILKKSDLIILSFCAAVV
LGIDKLYHSSFIQTYKNAVNEYENTPYWSPKIGFVLGGVSTFIFCMAVLSTVYFSNRMYY
MLGQHGVDVTQHIHRDILHLQVQFLTAMLALNFILLILILMVYRYMKFREYTGELDFLTG
IMGRKLFLHTCLRSQKSHAGTAGWFLVCDLDYFKHINDKYGHSVGDEVLKQFAEHLQNTF
RFCGSVGRIGGDEFAVMLDIDLSQDQLEHLLTQFLRDISGILEQVTVSCSIGAYRFVFPQ
EIKHLLTETDHVLYQAKENGRACFVIGDSTEK
>A0A5X3P4L9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weslaco|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARLSAMLTLETMYVSRS
GFYLSTLPTTYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3DVW1|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKKLKKRFIVPAVVFILGMCALIGAIYVVGESQKQQNRTNAKLNAMTYTERIYGELMEGI
GVTDTLKQVVISGDGNINKFYDIAANMMDDSIQSIQIAPNGVVTEIYPEERNESSKIDLI
NDSDRGEISRYARDNDTVIMQGPLKLKQGGYGIVVRNPVYLEDKNGQKSFWGFTIVILKV
PEIFSDSVEALSNFGYKYSLQKCASPWDDTYEWVYGSKEELNDPVIYDFDVYEDKWRLEI
LPKSGFYNNNYLIYMFIGGVIIVLLLTGLTAALISINENRKNFKRLAVTDALTGIYNRHG
FDEQVEQYMRQNPQKHCVVAMLDIDDFKLVNDMYGHAAGDGALQKLAESMKQYFSKDAIL
GRNGGDEFSIFMPDCTVVEVKPFLKKFTEETRKFYCKGEAHTFTISLGFAEYPVLADDRS
QLMHCADKALYEVKMRGKNGCMAYREGERIKSRAKLGFAVKDIIDNLPGAFIVYRAAKEN
DEILLANSELLRLTGCKNMDELLAYTGNSFCNLIRPDEQESCQKSIWSQINGGHSNNYIF
FHMRKADGTYISVLDHGRIVDSVHNGRVFYVMIMDLKSLQRHFGDCLKLVEK
>A0A6J5A9W1|diguanylate cyclase|EC 2.7.7.65|Achromobacter insuavis|TrEMBL
MDPILAELSASLQAAKSVEQLTRPLLDMLGAVTGLESTYLTSIDPDEDQQHVRYARNVGA
LQIPEGLSVPWSDTLCKRALEEGRMSTSDVGACWPDSDAARQLGIQTYVSTPIRTDDGLL
LGTLCGASARRQDIAPQAEAIMRLFSSVIASFLEREQLVAELRTANTKLMAYALTDPLTG
LPNRRALYEELDRLRGRALREGGSVLVGVVDLDGFKGINDTYGHQLGDAFLQEVSRRLAM
ALRASDMVGRLGGDEFVLIGPGPALARGDAAPGHEAERGDAEEAARSLEDRAAAATVGRY
QLGETALPYEGASVGVVALDPRGLAAEEAVRLADARMYEIKRARKAARVIH
>A0A1V5LSA6|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin429|TrEMBL
MPTINENYVLAKDGGRILVEWHGLNIVAENGDIDYFIGVGIDVTQRKTAEDALADSEALY
RKLFEDHSAVKLLIDPDTGAIVDANQAAETFYGWPRQTIKRMKISEINTLPAEEIKNQME
AARLSGRNHFEFQHRLASGDIRDVEVFSSRIGIKGKDYLHSIIHDITDRRRAEEEISRLN
VELEKKVDERTRELRDSQLALLNIVDDLNETTGNLAAANASLAAVNKELAAFSYSVSHDL
RAPLRNIEGFSNALSEDCGAQLSDDGRLYLERIRLATQTMRQLIDDLLSLSRVTQTPLER
KDVDLSALAQEIAGLVQSRSACGSVVVEIHEGMHVQADLRLVEIAMTNLLENAWKFTSKM
SHPHVWVGCENKDDETVYFVRDNGAGFDRRYANKLFGAFQRLHRAQPWRVAPRL
>A0A2X3IYN0|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MSTPDPHKKARTHGSRFIHRMYIMRMLGTFLCFLPIFSVLHEQQASLAVIALLAVNAFVW
PHVALLKARFSSSPVTSEKQNLVIDAAAGGFWIAMMSLSALPSVVIITILVSDRLAAGGK
PLMKRAMLAILLAFGLTWISHGMPFSPVVSARTMYATLPLIAVYTIALSMLTASIALKLR
EKSRELENIAMMDPLLGIANRRLLERKIGNELARLRIACGSSALMFIDIDNFKEVNDRFG
HKVGDAILMAVSDVLRVVTRSSDTPARLGGDEFVVLMPNTSLEEAEGIAQRILLESINVR
VLPEKNAFCTLSIGIACATKQMPDAAEWLKAADDALYNAKRAGKNRIYAA
>A0A5I0BCW7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Koketime|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7L6IM90|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00570|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHREFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A3P8KRU5|diguanylate cyclase|EC 2.7.7.65|Tsukamurella paurometabola|TrEMBL
MTESSSPLGFLARGESVVAVLVDEFLVSIADDVYLPLPAAVVRADLLTAFQSVIAALGAD
DFDPAVGRDVGRLLVALQITVPAGAAAGGRAIATLPDALVREPSAEVRRRTALILAEYTA
GYAEALTRRIIDGQAVVHRAAQLARRSAEEGERQAQARLRVMFEHARSPVFVADERGRVL
EANAAMTRMMEANPTLLGDSGHDVRPLLADDPADVARVLRELADADDEGVTRFLEHRRLH
FLGDSSAGRWALSRVPAEGDRPALLVGVGHDVTELRATHAQLSHLAHHDALTGLPNRRRL
REDLAERPAGPAGFCLVDLDGFKAINDRLGHAAGDRLLVATATRIRTALTGVGTLYRVGG
DEFAVLVSPPFRPGDAAQLVHRALTTPVEVPATDGAEARAVRIGASVGTTTTADAGSSVE
ALITAADAGLYRSKDARRA
>A0A8G1J9D2|diguanylate cyclase|EC 2.7.7.65|Bacillus pumilus|TrEMBL
MLRDLFINLTILVTFHYLFMLVFKENFLKKEDTLLRQLCKGILSGLLGVLLMFFSIKAGP
AIIDLRHIPLILTAFYGGIVQTIIAACVVIIGRLLIDANVGSFINIFSMMIIATASFLIA
ERHMNQVAKMLLSITISNVIATFLFITIAHETSIEVHSAYWMFSYVAGLFNFYVIEHQTK
AYQLLNLYKFQAHYDFLTGVLNKRKFDEVLSDAFSMKFKQPIHQMSLIYLDIDYFKSIND
QYGHHEGDMVLKEIGKRLMKNTRSSDYIGRIGGEEFAVLLPNCTVEKTWQIAERLRRKIA
DQPIYLQNGMSIHITVSLGCAYYPGTSADIKQLPIMADQELYKAKQSGRNQVSFSERKRG
QLI
>A0A1A8TRW5|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MKPDIKALEQKVIDVLANEAYQGHPLHDVLNELWDYNQSQWARMEHMIRLSDSYQDMIIQ
REKTLGERFDKHLRQLEKITRISDRYQTALREANLELEQASYADALTGLPNRRKMLRRLK
SEFEMCRQGICLAMIDIDHFKTINDAYGHLVGDDVLVSVGNLIERTVGELGHISRWGGEE
FLVIFSQVEQAQVEQCLRHLTKVIREAHFDNGEAYDIRTTISIGMSHYQADDSIDSLITR
ADNALYKAKNSGRDRFVIG
>A0A2N9NAA2|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatobacter sp. SbA7|TrEMBL
MGFALRPHVEPTPQHQRLGTFDLLLLLLAGLYLYLFLVIPWQYLAPEPQSYNPAYTFLAL
AEDVILLSIVVLGWRHSSGRWRHFYALLSAIVAFDTVMEYATDTLPAAVSFSGSWYDAAT
SAGIAGMTLAALMVYRLEPMSEREDPDSERYWRWASRLAAPFTLILPLLAAWSFLDRTLP
VPVWQFRVFLSLAAVVVFASVGIVKQARLEKELANANRELLDASLTDLLTGVRNRRFFTS
SIEADVQQVLRSFADYSASDVRNRDLVFYLIDIDHFKKVNDQFGHKIGDQVLAEVARRIN
SAARLSDAVIRWGGEEFLLLSRYTDRGEAHILANRILDSVGSKPYRVEASKADLRITCSL
GWAVFPWTASDPKLLSHDQILVLADFALYQAKGSGRNRAVGLLPAGQTVRAGTVAPTIYI
NGIPASPVTTPGPSLDSISTPSPTTPSANTAAASAT
>A0A6H2GDM8|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A0Q0HG35|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MRLMASNVENYFYHGFFVFLLITVVTCSIIATRLMRSSFNNRSIYLFNLFFYLGVIGFAW
LWIQDLLDLTPSFRSGVVIYMISMTLLQLSIYNHDEPSRFNKIIIAHGAIFSVFALLTQN
INQLALVEACFTLSVLPALIYFTTKRAVCEKNIGNTVLSMAQCILLLVPISQLSIITHEH
NLATLYSLTVIAHATVFVMTGLGLITTLLVDEKKRYLELSLKDPLTGLYNRRGLQFIIEQ
QQLFSPSQTSSLFACVVDIDYFKRINDSYGHDGGDLVLEVFSDLMKQHLNKGDLCCRLGG
EEFLLLFFATDISSAKQFLEGLRKTFETSQIAYREHLISVTASFGLTNWQPNDSFESLVN
RADKAVYAAKNNGRNRIETNSLNKE
>A0A485M142|diguanylate cyclase|EC 2.7.7.65|anaerobic digester metagenome|TrEMBL
MDRTKEKKPRSERPGPDTGICRLFFEASRDAFFCWDVTGRITHANPAAADLIGTKARDIP
GKDIADLFANPQDAEQALSALQQDGGEGLRKTCPLRRGKDRVDCEISFHVLRNNSGRITG
YGAVVRDISAQRLGDEELAKKTAELSKRVRELGIMYEISAVIDRRGRPFPEIVQGVLDLV
PRIVAYPEIACARITIDDEEYHSAGFHPTPWHIKSDIMARCGVAGSLEVFYREERPAAFE
GPFTREEKGLIDNIASRLGRVVARKRSEEMLVESEERYRSLFEDSRDAIYTVSRDGVILD
ANGAAMELFGYGDAEMIGMNVQQLYADPGVRAYFQSEIEEKGAVRNFEVRLKKKDGTVMD
CLYTSSVRRTPGGGGVIGYHCIIRDITESKRAENEKQRLIDELKDALDKIKTLKGLIPIC
ASCKKIRDDKGYWNRLEEYLEAQTEAVFSHGLCPECQKRFEEE
>A0A0U1K9H4|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MSEIESLSTLYRDVCVTYATLSISYFALSKSSAFSYHGEVWKRILFGLVAGLVSLYLNQD
QWVISGSFFYSFELIPIVLVTFYGGWLSSLTALVINFAFTGWVTLDNVLITIIFIPLLLS
RVWEKKSNRIFYITIILIAFYRVLAALLFVPNALIWTQIVVYQLISALCLAICYHALNFK
ERYIYAYFAMKNRANIDKLTQLNNRASVDYRLNTIHSSRQACGLMILDLDHFKLVNDTYG
HDGGDLLLTEVGKLLTSSVRDEDFVGRFGGEEFIVITHSHDPQTIKTVAERICQRVENLN
VELPDGRKIKTTISIGASLYLPGMSMLKAMKMTDEALYQAKKQGRNQVVYSRLMPFSPLG
DRINREGRRRRS
>A0A379YSM2|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MGKAMNARISDKHGLPVAIQLITLFLLAFLLSLLGIFTRPIGSLSLFWPVNAILLGLLLR
KPAYASPAGWLAIYIGMIAADLANGESLSLAMWLNACNMSLIATGYGVMSLLPKSQRRMG
KPQTTLYMFTASLSSAAVASTLSILRNDSLYNNTAVIAWLAWFSEQFSTNLLLLPVLLAA
PRLKQLLRMQINWQLRAGMPLLALLFSLVFSVYIGGPGAIAFPIPALLWCAVRYQLFTVT
LLTLLTGMTEISSISANLMLYETPNNHIAFLDTLMSARLGIAMLVMGPLILASSIAVNRK
LLRRLEHSANHDFLTGVLARNALTRKAGELLEHKHKSKEAVSLLLIDIDHFKQINDTHGH
LVGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALAAQGVALAEHLRQLVQKADL
LPTGKVPLNITISVGVASLGMNEVKSLEQLMNMADIALYRAKSQGRNRVESFNAVSGNSV
GHIMFK
>A0A7T4KK02|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator|TrEMBL
MTPHTAPPSHQAANDHPAPQRRWLPLLLAGAGYFVLAAAALWLARLPGTVAAVWLPNAFG
LGLLLHRPRAEGPWLLAGMLGASVLANHAAGDSVATALMLTGANLAEMLFALGLLRLLDR
HAVLGRHGPLAAFAVMLAVGGILAPALGATAGAMAIAATHGTSFASVWWTWWQADALGMA
LLLPMMLSMTEVRVRAAVARPVLAPQAGALALCLAIGAFAQWQSHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLCLQALMLLAHRHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
SSDKRFRQAMEHSAIGMALVGMDGRCQTVNRAMTELLGYSAAELHELSYQQLTHPDDLTG
DLRQVDNLLSGKIESYRLEKRYRHKDGHYRWVLLAVSLVRDEQTGEPQHFITQVEDIHAR
KLAQQELERLSRRIQLAAEAGGVGIWEWDFTSAGVTWDARMHALHGTDPAGGTPVVEQWI
AMLHPDDVSRVSGEMRQAIRGEAPFDTEYRIARPGGDVRHVRAMAMVTRTDDGTAQALVG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDAAMHVTFMNPIAEQLTGWTMASA
TGLPLEQVFRIVDEATGDPIPSPVEACLRTLAPAYLQDGAVLQSLTGERHDVQDSAAPVL
TARGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
RAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYMIRNHVRPDDVLARLGGDEFALLLKDC
TVDQAEQVCQGVIDAIRGRRFPWEGRVYDMGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPEENEDGAE
HCHIEILVRMVDEHGDLIMPGAFIPAAERYDLMGHVDRWVIRNVLRGYGERLGAVPGLSV
SINLSANSLGEPFLLPFLHAELEASALPASRIRLEITETALINNMAAANRLVTEMRRAGC
TVSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVRTV
AEWVEDERTLDALRAIGVDYAQGYVIGRPVALDVFLAGCRQRDAQASQAAGS
>A0A5K6CMT6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii (strain AB307-0294)|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRAIHIYDSEHHLIAQSFKLSSQTSVLEKWFDHWF
LNEPVHLTIYHHQQNVGELTLFGSSEKILQFLKMIMVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQILLDMFEDKDFDNKSALLFIDNNNFKSINDQFGHLAGDE
VLKEMAKRLQTRLRHQDFIARLGGDEFAVILHSITHADHLISIAENLLESCKEPLHLNDQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKTSEQHWFIYKPEN
>A0A1K0IQ00|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator|TrEMBL
MRPRLTALLDRLWEQAVRTPQRFVVLSFAVASMLLVMLSVHGLGLLRDHEIQSLQQGQQL
QVAGISSVLNVEAERLMSVRSFAQHLIRLQTGPHAIEPDPPLKAAYDHRNDDVWELPAPE
GDAVLFGVSPATLASLEGFPRRDGDLLAGLYVARGLSHLISAEPVNPLVARRLMYVSNNG
FFVAYPPVAPADAAATLRRVAAAGYIREHQPEANPDQSMRWSFGPAADGSDDVYLSLSVP
VYLERQFRGVAITEISQHSMDAYLTRTTPEGVQRFLVDIDGNLVGASTRDVRRGEKLSAI
LPASWHEATPQEMFRRGSGTLRAADGSRIMFQRIGNSTLALVDYFSATDLLLRTASHLSA
VLAASALALALLMWVTLQGIGKLFSHYQARGEALRELAETDALTGLTNRREFEARFGIEY
EHCLRDKTPMSMLMIDIDRFKRINDNWGHASGDRVLRKLADVVRATVRAIDVPARVGGEE
FAVLLPRTSLDEATQTAERLRKILGQTVCEPAADATGKGNIQFTVSIGVSDMGVDGTDNL
DIMLQVADRRLYAAKAAGRNRVISDDRVPEPAPGSVPAPAGTS
>A0A1I4GU92|diguanylate cyclase|EC 2.7.7.65|Azotobacter beijerinckii|TrEMBL
MPSISPEHQAAEWKRLLEQFPVAVATRVRELATAHQAVLAGYFYAQMLQDEEAMLFLTHE
QVKSRLLGTLQQWIAMLFAARPDEAELLPLIAQQQRIGEIHARINIPIHLVLRGARHLRE
RLFALLCQQPVDAEHKLLGQRLIGETIDLAMEIMSRAFSDAHDRNSRSEEGYRLFSVAQN
IGVEQERQRGALLDWENQLMFDLAVGHSLAQLPRLSGSEFGLWFRHKGAHAFQGSRETGL
ILQGMQHIDGVLLPLFEQAAAQMDADRRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQNERTFAVLAIDIDYFKQINDECGHEAGDLVLQQLA
TLLSSHCRGGDYVFRMGGEEFLVLLVDINANSALGVAEKLRRQAEQERFRLPGEHDLQLT
VSVGVALHDGHPDYQRLLRCADRALYEAKHGGRNRVVLSGGA
>A0A8B5QC06|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls712|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVTMFRCVVSLDVTQPGIMGENSHCVCRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHPWHFDSFQDALLAFTSSVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCCLIGQKKIPY
ADGEIGITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A1C3J4K7|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MVFSLLLVDSAEESEKQYGIENQGVTRSLAELTQIINALEYNITALYPLHSDTYVFSHEK
KVEGKTCYFISEEQQATRFDFMFSGPSEMCDLKSELHSEAGKRMFIAPTMAYFANTIDTI
SAIYFISKDKFIISSPSDFARYIKGDTFDSIVNSRPYWVNTIRFGLAQGQDQVVYTGQYD
DYLTGKKVVTLTKGIYVDGEFKGVLGVDGYVSNLVSNPVHGYKVTSARGVNKYGVLDFTY
SRPLYVDGVNTELYLTIEEGKSEHFLHILELERVQLLILLALYFVSALWLWRFYIRQEHQ
RLNDLAMQDPLTGLLNRRGFEERLLAQGEEPIIGVGVFDIDDFKEVNDQYGHKVGDEVIC
HVAQLMLNSVRQQDIVARFGGEEFVVAITGESSELLSSIFERIQNDISLQSYRCLTGDKI
NISASGGATLYSLSKFDSIGHLWENQSIRSSDEQLYKAKAAGKNQVNIHVH
>A0A7W2WRB6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVTPVNDTLLLTEWQALLRQTPPEVHAILTSLSDKEIRHLVTVFYDYMLSHAESALFL
NTEQVSARLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPGYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESAIAEIDGRLTQTLLNLQQPAEAARMSLLQDVRQLSTKIHFLLSSMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQANIILDTLRKKIADLRMAASAAESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>I3CK29|diguanylate cyclase|EC 2.7.7.65|Beggiatoa alba B18LD|TrEMBL
MPAVIPNHDNKTAVKDIEQKRLLEIYQNSQPLLEQVAAIVTPQAEQIASVFYSEMLAISG
AQPFLNHMLVDTRLRTSLAEWVKQLFTPSNEEEVQQHIKRQREVGNIHARINIPIYLVHH
GIRVLKRECRQFIIASCLERNEMANALSLVEELLDYSSFLINESYFNDIIVNERSAQALR
MNTINQGLAMECERLRSLLFDWLRRILTSLYQTPAPSFQQLPSIFSSDFGLWVTYKAELL
FIDHQYEIEHLKSQLLQINALVKTSIDLRDRSLMAELGVVINQLNDAVTHASWFLSSFIN
HALEMESGRDPLTHLFNRRYIPTIMQRAIRISATQGTPFCVLLVDIDFFKKINDTWGHDN
GDTILSQVGELFVTHVRAGDFVFRYGGEEFLVLLNDVSLDVAQRIAEKLRALVEQHTFYL
NKSMPFNITISIGIALHEGHPDYSVIISQADNALYQAKSKGRNRIEVADKLVGDSTNL
>A0A336QQL7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSTTELHSLDLLTFPVWIVSPQTEELVFANIVARELMQDLCFTPLRKGIFSTHYQNDLTM
YLSDLRNHHHIVEILTVYRDGEEIALASRLSIQSLPDVGDVILFEGIETPTAQGLKASRS
ATYQRKKQGFYARFFQTNSAPMLLIDPSRDGLIVDANLSALNFYGYSHDVMCQKHTWEIN
MLGRHILPVMHEIAHLPGGHKPLHFVHKLADGTSRHVQIYAGPIEIYGNKLLLCIIHDIT
EQKRLEQELERAALCDPLTGLLNRRHFYQVTGPEQTYAISLTQDYSLLLIDIDRFKSIND
LFGHLKGDEVICALARTLESCARKDDLIFRWGGEEFVLLLPRTSLDIALNLAEVIRATVA
KVTLPGLPRFTVSIGVARESIDELFKRVDDALYKAKHEGRNKVLAA
>A0A5W7FDH2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Goldcoast|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5W0A884|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Goldcoast|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A449BJD8|diguanylate cyclase|EC 2.7.7.65|Acholeplasma hippikon|TrEMBL
MFGKNNRKLTKYDVNHLYNQNKDSIHEFNVQFVPKAFTIVILALILGILLSFFRPTMKQT
LPIYLMALLLSSILLALTKLKQLRDRPLIVAYAFVFEMFTFVTYLSIFKFPDRAASSALI
FFVVVPLLYVDKSWRVNTFLFSMYLGHLVVSFIFKDMFVATADFVNTTVSVVLGMLFGRT
FYLNRLETFEIKKQLTKEKETDFLTGLYNRRKLYHDIEELSMQPNHNVNIMMIDIDFFKE
YNDKYGHVNGDLCLTNFSNLLKDMAEKYRIKFYRFGGEEFVGVNTNTNQDYFISIAKEIS
EEVKVMKELKETLTVSIGISKTSLSKIDDLVDQADKALYKAKKMGRNRIEII
>A0A3G8GVT5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pauculus|TrEMBL
MTPDTAAPVLPSPPPATGRGRPLLLAAAGYFVLALVGLWLARIPGHAAAVWTANAFGLGL
LLHRPRREAPALLGVMLAANIAADMLGAGHPPGAALLLSIANLAELAGSALLVRSMVGHH
AMARSGQLATFALTLGIASTVGPALSGLLGAWVISAQYGTAFPKVWWNWWNAGAIGMVLL
LPLMVSISRERVRATRQRPMLARLAGLYTLCVAIGAGALQAGHDPFVVMSLPLVIVALAS
NPFATALLTLLAAVAAECIGLVSGMEFLASRSVPLSGALVMVFPVCIAFMTEQNRKGRLE
LRSSERRFRQALEHSAIGMALVGMDGRWLVVNHALTDQLGYTADELRDLPFQLMTHPDDL
AADLRKVEQLLAGEIDSYRMEKRYRHKDGHYRWTLLAVSLDRDDDTGRPNHFIAQVEDIH
ARKLAQEQLEQLTRRTQLAVEAGGVGIWEWDFSQAAITWDTRMHALHGTPPELGPPTLAQ
WIAMVHPEDVSRVSTEMRQAIRGVRRFDTEYRVVRPTGEIRHVRAMATISRHEDDTTRAL
VGTNWDITEQRSLHRALFEEKERLHITLRSIGDAVICTDRVMRVTFMNPIAEQLTGWSMD
AAMGQPLEQVFRIVDEDTDLTIPSPVEQCLETLRPAYLQEGAVLQSLTGERHDVQDSAAP
VLANDGSVLGAVLVFQDITTSRALQRELAHSATHDALTGLPNRAWFEKRLRESCEQARAQ
GHRAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYVIRHQVRPDDLLARLGGDEFALLLK
DCSVDHAEQVCQKVIDAVRERRFPWDGRVYDVGASIGIAAIDADVPPVSELMSRADVACY
AAKAAGRNRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLYAQEIRSLRPGQDDSR
HVEILVRMVDEQGTLIMPGAFIPAAERYDLMGHIDRWVIRNVLQQYGTRLAGVPGLSVSI
NLSANSLGEPFLLPFLHAALEDSALPASRIRLEITETALINNMTAAARVVADMRSAGCTV
ALDDFGSGLSSFSYLKQFPVDYLKIDGSFIRNLARNAVDREIVSSINDIGHRLGVRTVAE
WVEDEGTLHTLRAIGVDYAQGYAIGKPMPLEAFLDTCESAEA
>A0A0N8TXR3|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MKDSSTAVSQVSLLKQKLNSAKLALEEIHEDRNEKLRTLIQFLGHLSLACKGQNLELDNR
LAKLRHHLQGYDQIDEALPELVEIERLLKGQYNHTMTQLEESRTSLSRVISQIQRVDSAP
EEIKKEINYFKKDLNKPIHTIWEYIPKVEQVIGFYEHILQKQFAGTDEHVILPQHLILAK
ELAQKISEIEFRKEQRDQILVMKEVLMGDIKLNTLLESYQTILSLLLNNIAREKTASQDF
LYALNDAISVVRDVVSNTANNNERSQQIKSQLNKEINLRVDNADGILIESDDLNALKTAL
TIQLSSLKDALSRKEALENREQTLLRKSIESMRKELTSITKEANSYKEKLFEHQKLNLLD
PLTQLPNRTALEDRMEQEYRNHKRFNAPLWVAVTDIDYFKSVNDNFGHSTGDKTLQVIAM
ALKNSLRESEFVARYGGEEFVLLLPEVNEDNIGLLLNRVREKIKNIPFKFKNQRITVTLS
IGAAQVMENERIEETFERADAALYKAKHNGRDRVVIDI
>A0A2K9JY61|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MQEDLLNSVIKITKTRDVDSLEYSLVSTIQEFIGCKEVAVYKDLLVPGEIAIERSLLLRK
LSDKEFDWEERSLVKEPDKELISCLQSACIITVQAKDGTEHRWVPISLQEKPVGAIAVIS
TGLSSADQVLLNAFCRIFENYLTILHENERDKLTGLLNRQTFEKRLKQLIEKQVIKQHKT
VWHGDVRSVHKGATSWLAIMDIDHFKKVNDNYGHVCGDEVLLLLAQRMRQFFRSTDLLFR
FGGEEFVLVFEPTDYDSIKAKMDEFMELVRNTHFPFVKKLTVSVGMSRISPYDFPITVLE
NADKALYYAKDNGRDMLCFYEALLSEHKIEAPEESSDIDLF
>A0A746JHI3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7D8ISQ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MRKKNLDLTAATMAHSLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRY
DARAADDKLIGLISHWLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCI
LLASGIALLLTRYLHNGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSL
LDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDG
DNFKYINDTWGHAAGDRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRI
CAALSQAFNRPFELHNGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSL
N
>A0A062C1A5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 263903-1|TrEMBL
MNEQCITMLAEQWKDICGQYSATDLNYTAQFIQDNSFLLVDEFYKNMMQEKEASYFLSDE
IVQSRLKTTLNQWLLDCFNMPFKQNYEEVVQRQLVIGNVHARIGIPSWLIMRGIREIEKK
VFSLQASRTQQNIYTVTNYIVQSIGFASEIMCRSYEANIEINNDIKHTYRLFSAMQDVSI
QKDKQRSSLLDWENELMFKVFSDSASFNHLLLSKSEFGLWFIHKAAYAFSGTDQVQIIID
RIYEVDKLNLAVLKSQDKANAIALIQQIREKNREIQHLVDQLFQVSE
>A0A5U0RM10|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVTKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A763XIJ0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLITWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T9L2A0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVIDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A746GJF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSLRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379Q3F8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A3J4IJ99|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A0L6Z9U2|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MLYDFYINLLTMITFLFIMGSIIRHIDFDLSKLERRIFIGVMFGILSIILMLSTIKIVGT
STILDLRNFSIVLASYYGFTVCLITALITIIFRALYYGVNLSALLALCNITATVLVCSYI
ERRKLSSFKTWVFKAGGAILALLVTISYLLWNVPNKNIVLMYYFLMNFSAAIIIYFFRES
IDLSNHKYSKYKAEASVDFLTGLNNVRRFEKLATSLLEDAKKNHEDLCILMIDIDHFKLV
NDTYGHSSGDAVLQQLAYILKLNCKQGDIVSRNGGEEFTVLLPRRTPSEAFKIGENIRKS
IEDNKFFLLDNKKIKITISIGIAAFPHNAQNLKELLLKADQALYCAKEAGRNKVCYACKL
KIND
>A0A1J1JKL5|diguanylate cyclase|EC 2.7.7.65|Planktothrix agardhii|TrEMBL
MGSLQPMFKRFKGYRGQIVPVFKRWLSQEGRVLVTASGVTVVVIFIRFLGILQPSEWALY
DQYFRVRPLESVDDRILIIGIDEQDLQQYGYPISDRTLARLLQKVNQGKPQAIGLDIYRD
LPIEPGQAELAKAFKTIPNLIGIELVENSGKSGVRPPEILENKNKIGFNNVPRDADSKVR
RGLLYLTDTKNKQKFHKSFALQLASIYLKNQGIESKPSPKNPNELQFKNTVFPWFRPNDG
SYIRAYDGGYQFLINLRGPAGTFPSIPMRDILENRVSPDLIKNRIVIIGSTAPSIKDSEF
TSYSDGIFKSSEPMYGVELQAQLTSQIISSVLDEGQLKRSTEFLQSIINTIPDPIFVKNK
DHQKIVLNQAYCKFVGYPLDVLMEKSDDQLFPKHEAELFRQQDEMAFNTSWEQENEEQLT
DINGITHYIATKRSLHRDAAGNLYLVGVIRDITERKLLEDNLKQIAAELKRSNAELRVSA
EHDPLTGLPNRILFQERLTQSLEWANRQNRMVALLFLDLNDFKHVNDTLGHQIGDLLLKT
IGDRLKGCLRGSDTVSRLGGDEFTVILPGIPSKSDVARVSQKILDTIIQDMVLEGQKVLI
TTSIGISLYPTDAQDMKTLIKLADTAMYRAKGTGKNLYEFYKED
>A0A663B857|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MPECHTPANRSIPSALARGTLLPALLVIVAVGCALVSPPIGTWREILANPGLYIDLLALL
FLVFMLWSSAKVRISHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRLSG
MLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILDID
FFKKINDTWGHLVGDEVLFSLGKQLAKLTSEQVLPARIGGEEFAIIVDGLSEPELHALAQ
SILDNARTILINHQAPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWA
>A0A238LCW3|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MTRHAKLISALIALMALRKPRDYLTKPLGFCAVASINAHIAEYLIFGGWIMGPVERIGIT
TMAAAPFMALVFYVVTYLDRLQLSLGEQAATDPLTGLPNRRAFMKRTQARLDILDEAPRG
VILLIDADHFKRVNDNWGHQVGDECLMAMAERMRTVLRTGDMLARIGGEEFAAYLPSTTL
EEAVRIGSPLCTPITVIPTEPPGRLRLTLSVGASEVRPEMTLSEAMHLADLALYRAKDEG
RARLVPWDGRVRPGEGRAA
>A0A1B7I0I7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella noackiae ATCC 51607|TrEMBL
MKNIQPLNYDIIKNEWQLLINNTNTATHQILMNLSDQEVWQLVDAYYQYMLQDEKAKLFL
STAQVEERLSASMNNWLRKVLGSSCEDLSELITHQRNVGEVHARIGLPIDLVARGARKLK
YELFQLLLNKPLLSEKEISDAIFFSGMAIDSAIEVMTVAFTPSHQKMMHDQEHFRLLTVY
DDMSVERERQLGALKDWENQFIYNIATELPFEERVLLSDSEFGLWFSHKGQHIFRQPDLI
KKIDSLIQKIDRLITTEFANESSNTFSRIHLLRLLRQDIEQVNMILSSIFEEIVKSENGK
DPMTKLLTRRFIPTIMRREIALSISSGKPFTIALLDIDYFKKINDNYGHAVGDSTLKSIA
VWLHEYARSSDYVFRYGGEEFMLLLVETTLSQAQLLTERLRNYIASQKIEVDVDTSFNVT
ISAGLVEFDNHPDYQRLINKADKMLYQAKNNGRNCIESYPFGMDNSL
>A0A658IHT2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Newport str. CFSAN000835|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2S5CZY5|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MPLKNEFGQVEQYLSINYDITDKKRMLTELKNIERTFRLITENTNDLIVILNEDGIIIYA
SPSYRMYLGYAIVELQGQFYSDIIDEQSKPAWQAFLNDFTEKTDTQFELLLQAKDGTPVW
TEGNVTVVHDSERETISQIIMVSREITHRKERENDLLYLAYHDSLTQLPNRRYLTKEFPK
ILMDAHAKDACIAMLYIDGDDFKDVNDQFGHDMGDDFIRKFGKVLITSVRSHDLVIRMGG
DEFIIILTGLTRKPEARQGQMMHIINRIRNELKKGWTIENHFFAPTASIGIAYYPDHATT
LEELMDLADQALYKAKESGKNNLFIGPL
>A0A069RR92|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium litorale DSM 5388|TrEMBL
MNMTGKDKFADSDKDSNFSAENEYEGEFFQSVGISNHLDLFENSHVAILIVNSRTGRIID
ANNAACMLYGYERPHMKDAEIEEIEYIEDIEMLSIGENTNKTVGKSKTVVHRLSGGKCRE
VEVLKVPSASDEDISYFIVNDISEIRHIKKELELRKSYFQQLFENSPEAIAILDNEDRVV
KVNRGFEELFKYSNIEIKGNYINDLIVSQELKLEASTLSGDVVCAKTVKRDSIRCTKHGE
DIDVSILGYPIIHDGVQVGIYAIYTDITEKKKREKKIEYLAMKDSLTGTYNRSYFIENLM
KEIMHRKADSHNGFAVMFIDVDDFKRINDNMGHNVGDMILRQISKRIVECIGEKGYLARM
GGDEFTVFLKNVDSRVCVANIAREIVESLEEPIIYDEKEFHVGVSIGISLFPDDGYEAEM
LIRKADMAMYNSKMNRSNNFEFYNSDLKKKALEEFILENELRHAIKREEFSLNYQPLVDV
SSEKIVGVEALIRWNHKEHGFVSPAKFIPLAERKGMIGFIGEWVLEKACRQMKKWIDSGY
PVRFIAVNISVKQLESLEFLDNVKRIIRETGINPRHLEFEITESISMTNLKNRTEILREL
DDMGIALSIDDFGTGYSSLGKLKKFAVRKLKIDRSFISDINIDPNNTAIVSTIIAIAKIL
NMKVVAEGVETLEQVEFLREKECDLIQGYYYSRPVTFDEFEKMIPQEI
>A0A5C6DQV6|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MIDTTPITGPSTGASIPVCPTEGQLIPGNTSKLEALLAGLQDAAPTADENPKRHSQAADL
KFENRLAMVRLGVATSLYFCLRAKHIPTAAHSLRVALSCSSWAHRLGLDEPARDRIEVAA
LLHDLGKVGIPDRILRKPGKLTVEEQLTMDCCPRLGCEILRGCTTDHELLDIVFHANTWF
DSRRVEEGPRGDALPIGSRMLAIADAFDAMTTDHVYRNAMSRELAIKELANGAGSQFDPE
LVIDFSRMLEDRPELLQGVVTERWLNQLNESSTSGLWTSTFNRSSEGVAMSHRMGSLRNS
DSPFFNALVGKMKDGVAFTDAEGTILRWNDAMQRLTSIAAEAIVGKTWNDESIRLREQED
ARSDAGCVIEQCLQSGASVCRAMVLEKPGGSPIPVYVQVSPVSASAHELSRASSRGSCGT
LIVIRDLSDQASLEQKVESLHHQTTRDPLTGIGNRAHFDETLAAATALTASGGPTFSMII
CDIDHFKRVNDVHGHPAGDEALIRFASILESHSREGDLVARYGGEEFLLIANHCDNATAT
KLAEKIRTALERTPLPSLGNESVTASFGVTEYQAGDSPETILARADRALLKAKDNGRNRV
IQLGAGNRPVEQTAAPKRTWFGLLARAEGKQNCEFDILTPVPAALAIEKLRGFIADHDAE
IIRVTENQLSLKVNAVCSEGGRRKVDHHITLEANLTLSEQVRGDASGAPGRKWQGTKVHL
AVRPLRSRDRRSRALSPCVSQLTASLKSYLMGEMIND
>A0A378YG27|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MTLALCAPADAGHLPPSPEDERLAAQALWRTAHMPGAARSAAPRLPSEGGRGRIDGVTEA
IDRVSTLTDPLNFHSHPDEAERLAALRRYEILDTPPEPAFDRIVRLASYVLGTPISLVSL
IDESRQWFKARQGLEAEQTPRSMAFCAHAILDDEVLVVPDARADRRFADNPLVVGEPNIR
FYAGAPLRTPQGHRLGTLCVIDRKPRTLDDEKRALLADLSVLVVDELELRRVNQVLGDMA
MRDALTGALNRRAFLLQAERQFAAARAQQRRLAVLMLDLDHFKAINDTWGHAVGDRVIVE
LTVVLRATLRKDTVIGRLGGEEFAVLLPDADAERAMQAAERLLTAIGGASVPGPNAPIRF
SASIGVGGLAPDDAEFGTVLQRADRALYAAKQAGRNRVAAL
>A0A084Y1G2|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MNDDDLIRALARDGVIRMTALLSLLMPASSGVGFGIKGLDGRYRLFNREMARLLGDGIER
LDGKSEDELLPPAVGKQLASCERRLLDGAPAAYEEVDLPVRGQTNRYLWLKLPVVGLDEK
LQSIVSIVHEVAPPPASPAMQQTLDRLQRANQELRRTVVELEQVAGTDKLTGAWNRRRLE
ECVRSEMDRLNRYEQPLSLLIIDIDHFKPINDQHGHVVGDQVLQALTRLLQSRLRGTDVL
ARWGGEEFIVLCPNTDRSTAAMLAERLRHQIERASFPVIGQLTVSIGAAECHAGDTWEEW
FQRADEALYRAKAGGRNQAQLAPDAIGPASTLEYIVADFVQLVWHPAYECGNELVDRGHR
QLFADANELLAAILSGGTADEVGVIVSRLIADVLQHFADEEQAIVAAGFPGATAHVVLHQ
ELANQARHLAANYGNGRQGVGDVFQFLAYDVVTRHMLGADREFFAHLQNHAPVRKNRPPA
ERNRRPPRPRVR
>A0A6S7BZF8|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia ultramafica|TrEMBL
MVSTSSSDAPSNDAPDLFQNESEALEKARAIHANVDADAQQCRLALAELIGHFERLMRET
RRLIGRSDRAEREMHALTQQLQYRATHDALTDVLNRSAVIERTSKALRVDRAVMILLDID
EFKKVNDDFGHPVGDAVILGIVDCLRRIVGEQDVIGRVGGEEFTVLLPGHDLADALQVAE
KMRGAIGSHVFPAPVNRRITASFGVSANPVRTDFDTAYGLADSALYKAKRGGRNRVEFAD
SHLAPPAMPTGD
>A0A0F0CIM3|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MVGEVAGSIQPMEHFSHSLAVRDMPDPGTIRESGLIIWNLDTGELPSELRLHCKKDAVLV
VCGERQWTDRLAACDLEAADEVWTRPLIREQVRVRIKRFLEVIKLRRDLYMTQNYLDTAI
DSIPDMLWFKSLDGTHVKVNKAFCSVVGREREDVTGRGHCYIWGVSPDDLENGEDSCKES
EDAVIRARRTLQFTEEVKCSQGMRQLRTYKSPIIDMDGTTILGTVGIGHDVTDLGNMSTE
IEILLQSMPYAILLWNNKGMIVNVNAKFEEYFQTLKEQVLGEDYYKWRAGTFEEQHTINS
EGYLEARAALRDGTEKMLEIHENSIYDIFHHVVGKLCIFRDVTTERDLERQILKSSNTDF
LTGLYNRRYFYQYIHDHRWNRAVSLMYIDLDRFKGVNDTYGHKVGDAVLSRTAVLLTECF
PNDFVARLGGDEFLVARLGDCTVERLELEAGGFLDRMTSAFQESDQMCTVSASIGIAQSN
RPDLDVDVLLQRSDLALYEAKRKGRSRYCVYQEKDE
>A0A0M7LTE8|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MLRIDLRRLILWISLLSIFLVLAAGLHASYLVQRDLLLHNALESNRVYAAKLAATTEYFL
GDLRRHLAYSADMLADMETHPELMTSETRRQEEQLGHFNSSFVVSAQGKVLAVSTSYPQL
MGQQMTSDAARTALTTRRPFISEPFRASTGRWLILYTHPIFSRDYRYLGYIAGTLYLHED
NVLDRLLGQHFNRDDSLLYVLARDGTLIYHPDRSRLGSMSANKTALAAALRGETGEARFT
DATGAEILAGYAPVPSTGWTIIAQRPVASTLLPLNDLLMATARNTLPLLLISILLIWLLS
RWIARPLGELASIAKHMQDPDSAERIRKVRSWYFEASQLKRALLMGLTSIQHKIRDLRRA
STTDTLTSLLNRRGLNEAMALLQAADTPLAIVALDIDHFKNVNDLYGHAAGDRALQVLAA
LLTEGSRSGDTVARSGGEEFVMLMPGSPLAAAVATAERLRQKLEALGTETGLPAPITLSA
GVACYPQHGATLDEVIQRADRALYYAKNHGRNAVCVADNQARDGARLALPR
>V6EZH3|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MAEPFFIPDLRTILVMTIFVFAIQGFFLWQLYRIKRRPAFALLACGCAVFSAGFVGYFLR
PYLGLNWLTVVVANLLILAYPVFLLATLMQCHGIARPIRALWWGLPGIIVLLVVAVLYLR
DNLLVVVVASAINGAFYLFIAAFVARRLPLNEPSMRMTLVSNLLLAVVLFGRAGVAWVMY
ENPQAAPAVAVWLSYTLMIALFCLSAQIYGLPLQEFTRSERTLEHLASVDPLTEVLNRRS
FFAKAQGLWQSHQSDGRPFSVLMLDLDRFKAINDRHGHPTGDRVIVAFARLLRDAMRHDD
LLGRMGGEEFAIILPGVATAQALEVAERIRAASEAVEVLSDDGFRVRLTVSIGLALGDGA
TSLDDLMKRADAALYQAKDQGRNRVVMVEQAA
>V6F1H6|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MTGIVPDHILRTLTDAGEIGIILIGQDGLVKLWNAWMTKASGITAEAALGTRLQDLYPQL
QGARVVGAVDEALHGGLSAILSSSINKRLFPLNHEGRTPGKPEPMQQIVAVKPVVVAEDQ
RDCLIQVFDVTTMSHREALLRQQARTMQALAENYRLSELHNRAIVDNTADAIVTFGEDGA
IGTYNPAAIRIFGYDPYEIVGKSVGLLIPGVLSKSGQLETERFLDIRAEVVGRRKIGASF
PLELSLNAMELGGQRLFVAIAHDITERKAAEEELRKQKEWLSTLINAMPDLVCFKDGKGK
WLVANKFYLDIAGLDHVDYHGRTSADLAHMSRGFGEFMLTGSLSDERAWQEKKPVAYEKE
LPTPDGGAKVFDVIKIPLYEEDGARRGLVMVGRDVTERKLAAARIHHLAHHDSLTGLPNR
VLFQERLRTALAQAKRLGHKVALMFLDLDKFKDINDTLGHHLGDLLLKAVAKRLLRCVRE
TDTVARLGGDEFAVVLTNLDDPEGASNVAESIIASISEPFGLDEHEVNTSTSIGITIFPD
DAVDSEVLLKNADLAMFRSKAEGRNNYHFYVAEMDAEIQARKVVEHDLRVALGTDQLEMH
YQPLIEMKTGEVVGCEALIRWKHPTRGWVSPVEFIPIAERTDLIVPLGRWILHRSCLQGR
DWARAGLPPQKIAVNLSPVQFKNHTALLAMIADILDQTGFPPDQLQLEITEGIAMQNVEA
TVDVLRQLRDMGVLISIDDFGTGYSSLNYLKRFPVDKLKIDRSFVVDIGLHPDNAAVVNA
IVTLGHSLGTRVNVEGVETIEQLDFLKAHGVDEAQGFYFAKALPPDEFARFVREKSPWPL
>A0A158SQQ8|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. KN65.2|TrEMBL
MHGLQHSYLFRVSPRMAWAIVVAMLALVASIEANSSPAMWFGPIYLAIMAFAAWSLNSLV
AVAIGLGILGARLATGELAVAASTGPAGTPNLAVRVLGIMIVVLVIGAARKACEREWRAA
RIDSLTGAWNRSAFFEILRKNQHRGGWHALIYADLDGLKRVNDEEGHAQGDENLKVFAET
VRKTIRKGDVFARMGGDEFVIFMKLKDKDAGTAVANRLDTALNTEFGESRFHLSCSLGIL
LLPEGSTSIDGELRAADELMYMAKKSRSGVLVSTACESGGRIEFSPCSIAKEVPRDDTVV
RQADRAPTSEPCMTPDTHAVA
>A0A509C5W9|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 3046|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNDNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A6H1YBM7|diguanylate cyclase|EC 2.7.7.65|Halomonas piezotolerans|TrEMBL
MRYKDKHQLAAEWQALLERTPVALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YAHIHATLGAELSSGEAAVYVSDHIDMAMEIMSHAYSVANNRNTRTEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
RHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLNREIEIARHSEKCFALLMVDIDHFKAINDTHGHDAGDHVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSIGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVAAATE
>A0A554X5Y5|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MVPSRRPLSVHACHCLLRRVRLAPWTPPLWQRVLPLLIVLVLLAGTGRAAWSRTDTDSAA
AAPAPVPVALDIAALQVPSYWLRPHARVLREPPGATALDPMTLLHRSDLPWQPVQDTDPV
FNFGTDRAAWWVHVPLAHRGDSPTTLWLEVTEPLIDFVDIWLIERGSARTLTELHSGDRR
PFGTRPIEHRHPLLPLTLAPGQAADLLVRVSTVDGEHDPLPLRLWEPAAFEAHARSEALL
YGAYYGALTVLLLYNALLALGTRERAFAWYTLFLGSFLVWNLTYRGFALQYLWPNAPTWN
QIALVGFSALIYATMAAFAWSLLELPRRSPWAFRAQALLAAAALGHAVWIAVDPTAATFA
TLDTVGLAMFAALIAGALHVAWQGERLAWWYLAALGSLFTGAGIYYLTKLEVITPGPLSL
QALNLGSVGEFLLLALALAHRINRLKTERDDAQRALIAALRDSEHRLEQQVNERTRELAE
ANAQLTALAERDALTGLYNRRRFDAQLPQELARAQRSGRPLGLLVLDIDHFKDVNDLAGH
TQGDVTLARLGRLIEHTLQ
>A0A379NEP5|diguanylate cyclase|EC 2.7.7.65|Roseomonas gilardii subsp. rosea|TrEMBL
MLAPLMPMSLMPMSEDDRLAALRSYDVLDTACEASFDNIARLAAELTESPISMVSLVDAG
RAWFKARHGLEAVEAPREHSFCAHAILEPGVPLVIPDTSRDPRFAGNPLVTGEPDIRFYA
GVPLVNPEGAVLGTLCVLDRKPRRISAGRQRILVRLAEAVMTTLELRRAMNRVHRLSMTD
ALTGLLNRPALMDALDKAIARLNRHGEGFALLYLDLDGFKQVNDREGHAAGDEVLRELAA
VLWDNLRREDMAARLGGDEFAVLLTGREPDAAIVAERLQRMLEAAMRAKGWAVTASIGAV
SFHNAPGDVDAALSLADSLMYGAKAAGRNRVLHRDH
>A0A1V2EV63|diguanylate cyclase|EC 2.7.7.65|Sphingomonas jeddahensis|TrEMBL
MGGTVKIAEQEAISLFKAIGAFLTEHRLSPDPAHYSFAHQVLSDPNGPLAQAVARLTDGG
VRLMQQDIVELGGVAVPGRPITLPDPDHHSPDPAKDAAMVVARTEQQMSSFAATVRSIHA
ETSGFGRDLAASAAAMRQADPAAALDHITHLTGIMIERVHDAERRLAAAESETNALREAL
EEARGTARRDPLTDLANRRAFDEAFAAVPPNTPVVIALCDIDHFKRVNDEFGHAVGDRVL
RAVGQTLASEGAEAGALVARYGGEEFAFLMTDIGVTAARTVIERARSAVAGKRFRSRETD
MPIGEVTISAGIAGGHATDAREALYARADAALYRAKAAGRNRVLFAA
>A0A822X177|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MLANCLSQKSRYIAFCLGCLFVIGILHALFLKLVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLLAIAFAFAGSASLMVGTLSSFPAWLDLYQFNVVNYNDAMIFYMF
RHLLIAVLFIVSAILFTTRNCPLSRLAHIAIVSAEFLFTAFVVGVAWMYSSHSSFLSIDL
VDNETREFMVLWSHFINIALIALWVVTLATLMFITRIRNLFWVGGNFLCVCYIVTLSMLV
AGGHVEGISWYRARLFETVATLLIIFVLLYDVFRLYRDSHIKYEQSYQNSIRDPLTRLYN
RSYFYESLKQALDIARPSRPVSVIVSDLDRFKRINDTYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLANTSSDAAYQVAERIRLNLSSFDNASSGGQLPEPITISMGVFTA
TSAAVAAETCVENADKAMYEAKETGRNRVVVFK
>A0A0J0FXR0|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MRSALTAFMPFQVDTPLRNAATIFILTTLFYFVGAELRLVEALSLFWPLNGVMAGIFARY
VYLNRLHYYAVCYVAMLLYDAVTTNWGMASVVINLSNMIFIVVVAVLVQRDKRLMKKTPD
PLNALRLFNYCLIAALLCALLGAVGSVGIDSHTFWPLFADWFSEQFSTGVLVVPCMLTLR
MPGRELRLRLEQLLPVIALIVSVIASVVIGGAGSLSFPLPALIWCAVRYSLPATCLLTFI
TGATEIILVANSIINIAVATPFTTPMMFSARLGIATMAICPVMVSVSMAAINSLIRQVSL
RADYDFLTHVYSRSGLYEALKHEETHRHTRFLTVMLLDIDYFKSINDNYGHECGDRVLAS
FARQVQQVVGEDGMVARMGGEEFAVVVNSGDAQHGFELAERIRSTVASHPFTWRHQTLYL
TVSIGLGSGKAESWQLTEVFNKLMAEADDHLYRSKKAGRNRTSARVADEQIAAPSGSET
>A0A379DN67|diguanylate cyclase|EC 2.7.7.65|Pragia fontium|TrEMBL
MMKIRSFFTIIILFIILSLSILSISTIQDNWSRLQLNIAEQNRIEYLQLLLVASEKIYDE
HQISHISKLYNNPDPINYNPANIALENLIAFSEKQTKSSHFLQDKYTALEIKRLSNIIRK
NESISSSYSFNRLSTIIEHRMIRIPNSSIEFMISVQGIRLTNRLYSSFTELIDQLIDICK
SNNTDTDSKIKAIKLLGGIDEIKDRLITIQKFYLNNSNEIEKINDLVNKIFNNNSEKANK
TIYKELVSMKYNDINIQQINVFYLQNKQHISLLSQLLLKQATDIANNQINTSKIKIYTMV
CFLIIFFLFSILPIIMMIFKLSDAFSLIQKAILQLSNNDLNINLKENQRRFSFELDAIIS
SLIKLKNIQIEKHLLENKNQQLIHQLKLKSTTDYLTSISNRRAFLETIKHSSPEYFNHSS
LAIIDIDNFKQINDKFGHSSGDEVLIKFSQLLSLFFRKNDLFCRYGGEEFAILLHDCDHI
LAKNILEKLCTKVRYLSVALPSGEKIYFTISIGIAEMNNKFDINQTIIHADKALYHSKAT
GKDRVTVYTHEMAVY
>A0A455VT08|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTANAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADARLYQAKQSGRNRVVWRD
>A0A328YA61|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia unamae|TrEMBL
MQHTPGRTRPHGFSSMVMKRPHLVVTVCFLAAMVLVTLVGLRQLYNMTRYDLQSRQRDLE
VRAVGVDALISAERRRLLFLRDYAEHVLASPSQQRAALGDPAVQAALHASGQPVWETPGA
LDGPPVFGTNAQGLAGLEGFHRDTATLAADIALTRAISPLVAISQHADTVQSTVAYISTN
GVYVLSPERRDAHVTDLLRRFSTMPYYRLQLPEHNPNREIVWTPIYTEEKQTGAIATLSA
PVYADGRFRGAVVMDVAPSRLLALQLVSATLPEDNEPTEFGLLNSNGDLVYFVDGKITAQ
RPANFDAPLLDLARRSAAAWMQREQGYVQRNGRYLLYQHVGESHWILLTNTDDTELTLAA
ARRVFSSPLIVAWVAIAVLLVGTLRIVTHIFGRYVEASSRLETLARNDPLTGLANRRRFL
EVFGETLERASRDDSAAPAMAMLMLDIDFFKRVNDRYGHAAGDRVLVIFADILSKNLRSV
DIPARVGGEEFAALLPGADMATAADVAERIRSAVETHAANAAAPGDAKRPDDIAFTISVG
VAASPADCPANYDTLMSVADRRLYAAKEGGRNRVVAEDSRSIDPARA
>A0A0T9V026|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MLIAYLDALNILSTPVWVVLPKNQEILFANKEARKIAGNCPLSLMRNGRFSAHAQQQLSA
YLPALADDDQIVEIWTVQTGKNTFPLSCQLSLTQLEPYGDVIVFEGLYISDTVLTQPNVG
QLYSKPYSRDVQGFYQQFFSTNTAPMLLIDPSREGQIVDANQAATRFYGYSRDEMCMKHT
WEINIMGKDVLPVMNEVAKLPGGHKPLNFIHKLADGETRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEHAHAQSQRYGQNFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIIRECDIVFRWGGEEFVILLPLTDLNGALQVAESIR
ETIQMICQPNLPQLTVSLGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A0T9TYS0|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSSTKKKSAGQIKNKTNAAKLPTLGRVLGKIHLTVAIISVATAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDKIVANEALSLIAANEEVAQAKILDVNGREIASWTIPDH
GPIHYIEQSVARWALPEPVVVPMIHAGNEIGKIVIVGHGGSLLRFLLQGLAGLLICLVLS
TAVALFLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAKIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAFFEGRLSRTLKDCKTNEHVAVLFLDGDRF
KEINDSYGHAAGDVVLTTIADRIRALLRESDLVARLGGDEFAVLLAPIHDTDDVLNIADN
IIESMTQPIVLVDGSEITTSLSIGIAVYPDHAQTPEELLQRADEAMYQAKKGFRPSERGI
VHQSGLTHTEDSQTESLG
>A0A0T9TNA4|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPKTPAMTLPIVMITAISLGTIAY
LILISKKYADKLNYFSIVLGVLWAWQIILKYEYLGTNENNYLLISLFTIFFISTIALSDN
FIAFCLHTAPATLAVIFLDDFHNIFRILFTIMLPLIGFSLHHLMSRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVEFAGKEFSNAESSP
>A0A380PQR1|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYNADEVIGHSFEIF
YTPEDLAGKLPQKGLTHANQFGHYETQGWRVRKNGKRFWGNLTLSALHDSEQNLQGFVHV
TRDLTDKWQRETALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGMPEKSLAKAIAEGNFQTEGWHVRKNGIRYWANVVINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYPSNEIIGQHFGSFFLPEDIAAGLPEKLLKTAASTSRVEREGWLVRKDMTRYWAVTVI
TVVHDHNGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIIALDS
EGRVELMNPKAEEMTGRSQNESCGLPIEEIFILWSPLQDKNQLVAIQQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQSISQLGNDDQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDLVARLGGDEFAIVLFNCHSKSATELLETVVADIASLQFHWHGQSYTFTASLGAVSL
TPQTENAAQAMRQADIACYAAKHAGRNRLSLAL
>A0A7L5RU52|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. ABC1|TrEMBL
MQQITNEDLAQEWTSLVERFSPEAALVLQETAAEQSADLAKHFYAYMLGDTHSASFLSHD
QVKTRLSKSMQQWVVTVFTPLAQINDLRTVIDLQRKIGEVHARIELPVSLVLRGSRVLKG
RLRHLLTLRGLSDALYREAICLGSDIIDLAIEIICFAFSQSHDRNSRAEEAYRLFSVSQN
IGTEKERQRGALLDWENQLMFDLAMGNGGDSLPKLAGSEFGLWFRHKASHAFQSSPESDS
ILDYIEQVDKALRSIPDTPQAGGDHGLSVLREIRQQTRAIKFLLDSLFEQANDLEAGRDV
LTRLLNRKFLPVVMSKEILYSRQSGNTFGVLAIDVDHFKSINDRHGHDAGDAVLQQVATL
LAGNTRGGDYAFRLGGEEFLVVLVDINPDKAIIAAEKLRESVAQERFKLPQGGDLKVTIS
IGMAVHNGHPDYEKLLQQADKALYEAKETGRNRCVLYR
>A0A5C6G3G0|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MFRTYFAALRIAFALTCVSVGLLISAQMFGVVPDVDHERMKAKQSYCESVAIHAAMAVRR
GQWSDLDGTLKTLVDRNPELLSIGVRSDLGILRLDTGYHESFWAADSGRNDAGPLDSNSH
LSTMPIKTAGSMSSMMSPAASTPADPPESGLVSTVKNRIRQTATEMWDDLTGLPGKLASL
PEEIRQSLRDTGDESAAVKTNTVEVPITLNRRPWGTVEFSFQGDQASLWGSLTSRSLFPL
ALYVGFAGLFAYFTVMAKIMGAFTGSQVVPDRVRGALDTLAEGLLLLDDKGHIVLANQAF
LSCTGSVASEVRDRKIDELPWVHDADSSEDQHPWLRSIQSSESITTSIQRYRISSGEVRV
FSVNTAPIGGDNSKRGALVTLRDVTHIEAHRAEQERMLSMLRSSRDEIRRKNRELELLAT
RDSLTNCLNRRAFFERFETLYSTASSNGTTLACLMFDNDHFKSVNDNYGHHIGDEVLRKV
SKTIRDRHESRHLVCRYGGEEFCVVMPGCDLSQAIHEAEETRRAIMEIRLDDPAELRLTA
SIGVSELVNDPADPQELINQADACLYIAKQRGRNRVVAYEPGFEEQQESGKADDSRAAPS
AATAVTGPAVPFQAVTALLGALSYRDSQTAEHSCRVADLCVRTARGLVDQKQLYMFEVAG
LLHDIGKIGVPDHVLLKPGKLTAAEWKLMGEHDRIGVDIIEGTFDSPMLTEIIHSHHAFY
AGGGRHDDLPHGKDIPLGARILTIADSYDAMVSDRVYRKGRSHEEAVEELRRCAGTQFDP
DLVERFIEKIHPSELGQGLDENGLTKQVALKIGMHVELIADAMDHRDVNRLRELAVTLSG
LAKSHQIDAIAHCAQSIETRAVESLERVKTAETATGISAFEIMDPEQEEENDWMQLLCEA
NNLLDLCRATQNVYLGDTTERNRQIIENFLADIDA
>A0A4P7NYD2|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MSDKKPLVQSFPPRWGYFIAIAVVGAVALLFQLVYSLKQNQALFDTQVKYLTENVQGAFY
DSATNLKDKYNFLLLHYSHLEGITRLVNHADREALYQKVKVDFDAMQQKDPSLFVMHFHD
PNNITILRVHNPKVYGDDVTNTRPMVVYVNNNRHQISAFEAGRTGLSYRINTPFFSENGQ
YLGVLEFGVKPEYFIKRLKNRFDVQARLLVKKRAFKHFKYEENYPVVGHYSILYSDPIFN
EVEIHKSEKSQLIHKDNKTYLVVSGLHLDSYDGHTLAEFQVLEDITHFYQKHMRSFWLHW
VLNVAGLLVFLILVYFILKRYSDRLMRSMNTISVLQQKNEAMKYSSEIDELTQAYNRRFF
NQKLRQLLHYQDKRHPVSILFYDIDFFKQINDTHGHLVGDDILKSLSQFMRSHLRSEDIL
VRWGGEEFAIVLKEAHLKEAVEKAEELRQAVAEKTWPNDVKMTISISVTELHENDNLKSL
QARLDDLLYQAKESGRNRVEFE
>H5WV57|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium JOSHI_001|TrEMBL
MPRCNGVSTSSFACPGTFKKKSMTSTPLRQRTWQSTRDLVDKPTRQAVATAVDHAADALA
ARFYAVLLADPQASGMLDHQVVNTRLRASLARWMRELFKPESTLDACMTTQERAGAAHAR
MGVSIELVAQGARVLKRGIAQELAASPLPRPALALAVQYTYEMVDLAVDAMNQAYASGSD
RLSRSDEAYRLQFLSQNMKAERERQKSGLLEWANQILLQYFWEAPEAMHPPGLESGSSQF
GLWLRHKASLLFDGAPQVALIEAHIARIEGELLPELARVRGQRDTSLTVVRSITLQVDHI
KRLLADMFDSYVAEEDGHDAPSRLLNRRYFPAVAKREIALAQQHHSSFAAVALELDGLEG
LRASAGSSAAERMVHQAAEALADRVRAGDFMFRLGDAQMLLLLVEVGPQQAQGVAQGLLN
CCRERALTGPGPASARLTASIGLALFDGHPDFQRLLDRAQQALQAARREGGDCSVLSD
>A0A1U9Z413|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MMSIKLENSSFEQMFELAPIAMWVEDFSGVKCLFDRWRSAGVTDIEAFLRADRSRVAACS
RAIRVLQVNRKTLDLFEASDMEQLVSSIDQVFRDDMLESHINELVQLFQGQHSFSSNTVN
YTLSGKRLDIQLRGQVLPGHEETLDRILLTTEDVSLREAAHRRERAQALYAQGLFEHSPV
SLWVEDFSRIRNLLEDLRSRHIVDLRVFMDVHPDFVRQCLNEIKVIDVNQATLDMFRAAD
RQTLLQNQHAIFRDDVEEHFREQLIDLWEGRLFHSHEVMNYALDGSERYVLLHFSVLPGH
EHDWSLVLVSLTDITARKKAEAYLEYLGRHDVLTKLYNRSYYTEEINRLERKKFRPIGVL
IIDLNGLKEANDSLGHDAGDGLLRRLGEVLNEAVSAPHCAARIGGDEFAVLMPGAGENDV
KVMVEQIDKLLDINNQFYADAPISVSVGVAICEMGETLESAVRRADLEMYHEKREYYASL
PALDRRNRRR
>A0A3U7DLQ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGLTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A822WDV2|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MEKRKKPTLERATWPTRHAMVMHGLAMNLPWLAFVNISFALMILLRHVLLNASDPLYPHL
PHMMKMVDASMLGIIILSAALILMGWRRIAGISVVLCICSAIWSISCFWFITDLLLPHVW
PLCVILLLAGLTALYFYPVGLLAFVLPLWITLPIASWVLNDGLNLHFVIIWSVFSLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTTTANRRKMEVVLENAVEQKKPFSL
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPEN
IAEKVAVRIQDGLRAESIPHSASSVSDRVTVSMGIAGMVEGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A5P9JAY8|diguanylate cyclase|EC 2.7.7.65|Maribius sp. THAF1|TrEMBL
MDAILTRRTLDALMPMHLLLNSEGRIEGVGRALQRLAPDRKLIGSNLRDVAVLDRPAGMA
SIADLNGRRVALHLRNQGKTYLRGHGVAIDGGRLLLNLALALGELQKVGDSGLTAMDFAP
TDPTLDMLYLIEANHLATTQTHRLIGRLQSAKTTAETQATTDPLTGLVNRRGFDSVLTRA
IADKKPFALAHVDLDHFKAVNDRLGHPAGDAVLVAVARRLRDIVRTSDTVARVGGDEFTI
ILHRLTDRDTLSDIARRIVAELEQPVEFEGNTCRVSASIGIAISRGGDVKDPDTLIADAD
TALYASKAGGRARHTFTAPRSIS
>A0A447PE40|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MSFLTPVYLAGTLKGIVMVDVNQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQS
KNNLFQYVNYSHDIPGGLRVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRN
VTRENISDAMTGLYNRKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGD
RIITLLAKAIKTSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTV
HFSAGIYNMQPNDTINDAYQASDAQLYLNKQQKQHRSS
>A0A379WEV0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MRSLRHVDRADGRQYVACRRAVYDDEHESDGGWRAAVFTVGMGLLLASCLVTLQLTGLPV
AMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWE
IFYVMNSITADATIGRRHY
>A0A379X202|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MLLTTAEPQQARATAERIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIGDAIEKA
DKALYEAKHLGRNHILVSDDMRAL
>A0A509E148|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MTLQGNTTTIMQITLTEKLKAKFAIILLSITLIALLMQTFFKKTYVIDTNSALTYSVRDD
ESQGGHSRVAVHVKDNKFIFQCTIGESDFAWPYCELSFHLFNSKRNQGLDFSKFTHASLW
IEYTSEAKDGIRFQTRNYDPVYSKPGLERSLKFNVAEVHADFLTNPVTVPLKYLSVPTWW
LEEFQVPLQKTLVELDDTRQIVIVTGSNIAPGDYTIEITRIALQGKYIADNTLYLMLLAM
WVAAAVLYVLDKLRSARKEVHLSRRHQKDLESLVQLLNVTKHELEHKLTRDSLTGALNRD
GVAKVFEYKQSHKEQDLSVIFIDIDHFKTINDTHGHNLGDKILIQFAQLLTQNTREGDVL
ARWGGEEFLLACPNTDLQHAVSIAEKLRNCVAQYKWQNNITITASFGVAQMQQELATEFI
GRADEALYTAKALGRNRVVAAGSELEA
>A0A752VRP8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Carrau|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A447PK70|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVF
GGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAAL
FMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPL
LFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAI
TAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A447MX04|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MMKIFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVFG
GWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALF
MMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPLL
FAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLII
DIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAIT
AMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRT
EVAA
>A0A8B3VB89|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MALHSKKLSFTRPIMVSFAGILLSFALIAILVILSQRKDFLEDYHKINGNFTHNLAVNYT
ESILRENDYILGRAAMYFARNDRVNQTINIDPTHGLQMLMHLQNLMPTVSSISLADTVGR
HLRAPEVLPTEKGKSFDARTRPWFIGQAEASNFPHYTRPYLDYFTQHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
QMTSGEGHLFDPKSKTWYYYYSFTNPDWFVIYRVSDATLTVITRHETTVVGWGFALAAII
IILFGLYLRHASRSVLMNIINAIKTGDVNQAPRLEAMLSHTIRTNKERELAYVRQATHDA
LTGCKNRRAFDNDVDELLTAHQPFVLALVDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFGVIFPAELMNSAHALLEAWRTAVEKRTWREENLRVTFSAGTGEW
HFEPLEQFIGSVDEALYTAKQQGKNRIVSTASR
>A0A0U5IE25|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MAGFRNPNAPVAAGQGFLRLINVIGLVLSGTIALLLPLGYFAVSYTALVSTLEAETTIKA
ELIDRLVSVEPALWQFQVHRLNEILVRFPTTLETERALIRDGAGVVLVDTQTPLPMPVVR
REAPVFDSGVLAGRIELQRSLRPVAINTALIGLLGLLLAGSVFGIIRTLRIREHGIMEAR
YEEQERAHVTLQSIGDAVITTDGNERIDYLNPVAESLVGWRLAQARGQPLSHVMPLIDEH
TLKPAPDALAQALCENDHWSRSNPVALRRPDGSTISIDDSAAPIRDRAGQVIGGVLVFHD
VTVARSMAQRIRWAATHDALTGLVNRREFESRVEEALATARNSDKHHTLAYLDLDRFKIV
NDTAGHAAGDALLKEISALLQEKLRESDTLARLGGDEFGVLLESCPLDRAELIAADLLAS
VKGFRLNWEGQLFSVGVSIGLVAISGGQDTQTEVFSAADAACYAAKEQGRNRIHVFRRTD
AAVAERRREMDWAAKLCRALEEDSFVLFYQSYRALATTDAGAEIKHIEILLRLIGEDGNL
ILPANFLPAAERYSLICAIDNWVIATTCSRYADLVELLGAPLTCGINLSGTSLNSDDLPG
FIRERARLYGLPPGALCFEMNETSVINHLRRTRQFIDHLKELGFYFALDDFGSGTSAFGY
LKNLPVDFIKIDGSFMQEIEKDSLNRTMVEMINRVGHLMGVKTVGESAETERIIAELKSI
GVDFAQGYGSQVPVPLPVAGRAVSVRDRT
>A0A2S3U856|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum subsp. plantarum|TrEMBL
MMIFVFGMQAAVVGQNDAWIFMNFQLIALIFCGYFLNVRVRYYYLYPLVFIFMGFNHSLY
YWESWGHAVTLILFFTALGRLRKHVPLQTKQGQVALYLVTCAGFGAVLWWFMKLKFNLSW
ATYWQEWTYLLVFASLLYIYASMLSANAHLKQNLVAFANHDALTKIENFAAYKTAINYQV
TSSRKNGSQLTMLMFDIDHFKQVNDTYGHLAGDKILQHVAQVATIVCRANNPQIALYRTG
GEEFNVIFPNYDLTEALAVAEQLFAAINHIAVPVNDHQIQLSISVGLSELAADDQSPTAF
YQRVDANLYHSKKHGRMQITAK
>A0A8H9SIQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7M3J7J0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEYDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A377ZB24|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MGRSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGL
ISKWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTH
SLHRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQ
AKNAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGH
AAGDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPF
NLHNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A3W4GKI5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NVLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGKLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A838APH0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYTQKNLALTAATMT
YSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNCINTLMSDSTVRETSALLFLDGDNFKYINDTWGHAT
GDQVLIEIATRLMEFSGKRHQAYRIGGDEFAMILYGVLSEYEVQRICTALTQTFHRPFDL
HNGHQTSMTLSIGYALTREHASVEKLQELADRNIYQAKHQRAEKLVK
>A0A8G8WC33|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLLSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSREIESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARTLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8G8LL96|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNISKSGNYTNLCTGSNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKH
LQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVS
DALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTL
FTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSENYW
YGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELALL
AQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFT
TMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPF
SVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASL
TQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLA
KQAGRNRVFASDNA
>A0A3P5ESE4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQYPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8B5N311|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILEHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6D0DFJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLRHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADRNMYQAKHQRAEKLVR
>A0A8A9C6M0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGWWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8G9NAP0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
SAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTM
VMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGL
TFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPL
YFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIP
PHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLN
KEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAE
KMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVH
YSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQ
TVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEF
GLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQA
DIACYASKNGGRGRVTIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQ
ARNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSI
ALPLSVAGLSSATLVNELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRIVF
SQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPV
VLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A6D0QBS5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAESW
>A0A8H1R8A1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDSFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVIIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X5E8Q8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8H1EWZ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGLRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H1NZP9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAPGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A827K0N8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTKFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTGGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A2I5ILN0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVVQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A853WIM1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLS
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A7I0HZR5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASCEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHS
>A0A377E4N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQ
HMAALALEQEKSRQHIEQLIQFDPMTGLPKRNNLHNYLDDLVDKAVSPVVYLIGVDHIQD
VIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRN
VVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNE
MVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIP
LAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHA
WGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTE
IKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGY
FFPAPYPPKKFQAG
>A0A8G9NQ87|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNSETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNIYQAKHQRAEKLVR
>A0A797I1S4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPN
>A0A5D8SMS4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEXGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A6D0IGN1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
LTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRN
FSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFR
SGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAY
RIGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGYQTTMTLSIGYAMTIEHASA
EKLQELADHNMYQAKHQRAEKLVR
>A0A7M3J7W4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWFECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8H1U507|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTNRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3P5DR49|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRL
PRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMRHMPWLPFLLILLPANIMTMVMYAF
RAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQL
TWPEDLNKDLQ
>A0A376MS03|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKPMQY
>A0A2X7I0J6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELT
ETEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDA
NLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRH
VQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQM
QHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEF
VLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDAL
YRAKNDGRNRVLAA
>A0A2X3LY54|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAME
HDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLI
SWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQV
DLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAE
VAERIRLKLNEKEMLIAKSTTIRISASLGLVAARKPVIMILNNSSHWLTVGFISLKQAGR
NRVCASDNA
>A0A376S6U2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAKEFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVV
IGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A4Z0JM64|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQTMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376LNU8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRYCRAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAI
ALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDIS
VGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLY
EALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFAQHIQKIVGDKGLVARM
GGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGCASYRTLTD
DFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>W7WHS6|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MTDLLGSVVSLTGYRDRDLLDAAAVTMLADWLRPLSLSLYRCVGEAGDTRLLLQACARDG
PPAVAGDPPWTPLEALPSLDDWLPHRDALAGGEPLLALPTSRPGPRGRPVLLNVFPLWVG
TERFGLVEVLAEKPLDAEQLRFVDAVLKIYRNQVGLLDYSERDTLTGLLNRKTFDEQFGK
CLLECDGPGPLAPLSPSADGGQQPERRARASLRYWIGVVDVDHFKRVNDNFGHLIGDEVL
LLMARILRGAFRHGDRLYRFGGEEFVVMLHADSRVHAALAFERFRARMETCRFPQVGSVT
VSIGMTELRADDTPSAAFSRADLAVYHAKQNGRNQLQCHDQLVEGGTLVEAGGKVGEIEL
F
>A0A1C3RKE2|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MMVSTPSALGLSKKSVYVRAFLVFVVGLCLSISASYFVLQFQDEQNKKRLLQDANEYVHA
LSRELDRKANILSPLSGQFHLEKKKPTREDVTKALQELSPLLGGLSYDDGFSYLAWAPTW
LGRSKATFKDIVALEDWQQERTGRFIMSHLQKWHFNTTRPVQKEGAVFGFDHNEKRGEFY
LVIGQPFFQQFQLLGSSNEAQQFPQGYLLGWLDIAKLIRKSWDGLRNPNNLISLKITKSP
QLDEYLLYHSGLVESQTLEKIQKIFSTAQSHSFTLAGMHMELSLLPLNKKQIGFYQDLHW
ITLALGVASTLIWCLMVALMGHHKHTSEYSRNSLEDYGRKLADETHQRQVVEDVLRMNEA
RWHYVVDNLPIALFAVDYDGMFTLGEGRGLEALGLKAAQVEGNSIFDVFKDYPLIINICR
ECLGGEERRETFLINHHWVDMRFTPVIQPNGGFDGMICVASDVTEEYRVQERLDKANLHL
QGLMDNLPTGVAFVRSGVIQWCSQRLEEMFGYEPGKLAGRAPEILYNEVESYRDIENRAR
AKLLNNELVEFNTVFRRNEGGRFYGDLIGRAVDEKNYHAGTMWVIQDLTKILEEEKYRRL
SKTVFDNVTEGVMVTNGATEITFTNNAFKSITGYSDHETLGKKPSFLSSGKHDRSFYQKM
WTTINEIGTWSGEIWNRRKNGETYLEWLTITALQDDEGAIEEYVAVFSDITKYRQSQEEL
RYQASYDKLTGLPNRQLLEDRFHQACAQATREDKPFAFVYLDVDNFKFFNESLGHDYGDM
ILKEIAQRLDGAMRSVDTIARIGSDEFILLLVGTGEEDTVSRAVTHLLSRVKEPFKLPEL
PEEITISASCGIAIYPDDATEYSELIRKADAALYHAKETERGIFMFFTEDMNVRVKERLM
LENKLRRAIEAEEFTLYYQPKVIAETGEITGAEALIRWVDPELGIIGPDKFIPVAEETGL
IVPIGEWVFRTACAQMKKWKDMGLSITNVAVNLSGRQFSKPDLAADLMAIMEEEQADPKM
LEIEITESFIASSQSSMVESLAVLSKKGVKLSVDDFGTGYSSLSYLHRFPLDIMKIDRSF
IMNIKEGEDDTSEKLAKAVIAIGKSMNLKIVGEGVENDTQLEFLRENGCDYIQGYYFSKP
VPADEFEKLLQEGATL
>A0A3S4KH99|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMF
SLFKNGKPVTGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDVYLRVCTLIIFFAAL
VAVISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLD
DLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQI
PVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVE
RLKMLADERLYKSKKNGRAQISWQ
>A0A5C8XY40|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGKNRCMFIDEQNVINRV
>A0A377AZ44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVAGVGRLGVRLAAFSLADSEQGVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLM
IMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLF
GWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIID
IDHFKSINDTGAMMWAMKR
>A0A0K5VYM9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGYYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A827YH38|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAA
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLL
PRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAK
MMDATACWRHKPRMRLEINDCA
>A0A376U4K7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRARNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFIS
HWLFPAPSFSRFVTMVKPLAKYA
>A0A376ZX66|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLGRRVMPIMHEISHLPGGHKPLNLFINWRMDLLVMCRPMPGRLKFMATSSCYVLCMILL
SKNGWRSSWNMLLTMTR
>A0A379D443|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MKNVQDGVRKRQALLFSAAITLICLTLWVFFLHQNRLSQVSNGMSEMITRMIIVFNDNEL
IADATGVRFQQLRNANRCGEMSDFRRLDNGSWAINGDKTRLNPALGTLISRAASQDGRCM
YAAAEFIRHKINELNPGEFNVHRYIIARDAEWLYWFAPEDSTLFSFSDSSMAKDPAAFFT
PPVSFYDRVLQKNVRIKASSATDFYSDKITGGRAYSIVSYIYDLSGEDVSSHIVGYLLYD
HSQKELGRELTNAFAGALPPGLMVSLYNLSTRESVCLTESCSWLRPQVTRQISSRYAFRY
ALPLYLLAIRDPAASVAIVLSPLLFLLIAFFLRKRLNLHDIKTYTDPLTGCFTRKIMEFI
RNRQDEYSVVILMDCNKFKAINDTWGHGVGDRALQIIARQMMLNVRSEKDLVIRTGGDEF
VILLNQTPLAEAKSIAGRVAERIVDSDFTAGGAKIPLSVSWGVSLFQGDLDETIQLADAD
MYRMKHELHEGDEARRAASAKKSPAGGDGAKTH
>A0A1Q9R1U6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MMDNKRGKGLSFVRRIHAPRTIGMGIGLLGVYAGMLPLDPPTWVWIAMFINGLAWPHIAY
FIGMRSRTPYQTEQRSLLIDSMTGGFWAAAMQFNPLPSITTLSMMTMNNVAAGGQRLFLR
GMLAQVCGMLLGMALFGPGLQLVSTTQQVYACLPMLTLYPLALGWVCYRLAIQLTEHKRS
LSALSRTDSLTGLLNHGSWKDLLQLKFQTCQQQRRSAVIAIIDIDHFKRINDSYGHVVGD
AVLRHLSKELKINLREDDLAGRYGGDEFCVILPDTSLTQAGRIMERLRERVAAYRDESLP
ELRISLSIGLALCRSDFDDPVAWLNEADRALYSAKNNGRDQVNFADDGSASARVAYPE
>A0A109BV91|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MNNLDLMSRWFQDNLDHVFFFYGLAFVLLGIVILTQPRKESTLSLSGIIWILAAFALIHG
LNEWFDMFVLMHPDTGIFKTLSWICQVSSFACLFEFGRRFLSICGNTLLHGFSRYIKWWL
MPLGLVVIGVVSFVSADGLKAGGVAARYLFAFPGSVFTAAGFYYYRSDISIIKHKAVVNK
YFLLAMLSFSAYAFFGGLVVPKNTMFSFSPITHESFLAFVHVPVQVFRAAMAVMSAISIA
GLLRIFYWEQQHELKKRNDELLLSKELLVHNAISQDIINQILRVSLLPVSPVSIEEQLDK
ILNLILSDTWISFQAKGCIFLCEEGYDRLILKSHHNFDEEHIRVCSSIEFGKCLCGMAAS
KKDVVYVPTSDSVYHTISYPGMQPHGHYCVPIITNDRLLGLINVYVNYGHVRKDEEELFL
KNIAATVAGILIRKEADDKIRYNNLIQQVINTILELSLKPISLSEHLHLSLEIISTVPWL
SIKETGCIFVAENSSEILVMRAYRGVSPKLLETCGRLPFGKCLCGRAAVTGNTIFKSNLD
EHHDVRFDGMKNHGHYCVPIKSTDRVLGVINLYVKEGHVRNALEDDFLSYVANTLAGIIL
RKEGEDKERALFNELEIHRNNLEELIQIRTSEIETARNETKLAFEHLKIIVDTISAPVLV
VGMDYRILLMNKAVKEFYFGGINDSTDGLTCFELFHRNSEKCNNDYFEDCTIEQMCKSQN
PFCVVHKHYRHDGQLRILEIHATPLKNINNECEAVVMVNQDITESKMRESQLEVMASYDA
LTSILNRAAFVSSLSSIIYRANENNQKAAVMYMDLDYFKEINDTFGHDAGDLVLQRVAMR
LTRSIRDKDVVARLGGDEFGIVLVEAADTAFVETVCKRVVEAARRPIVTDKGTFNIGISI
GISIFPADGDKEELLIKRSDIAMYQSKRNGKNGYTFYSKALEDLQ
>A0A379KNJ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MVFPAQSRLLPYFAVFGLTFALTLGGILARPIESLSLFWPVNAVLAGVLLRYPRHATPVS
FTLAWLAMIAADLACGSAWLSALWLNLCNLSVVVTVWLLLSRLPRLHRRMRSPQGVLSVF
GACAAGAMVAACMACVVAAPWFEQSLRTTWLAWFSEQFSTAVLVLPVLLTAPSARALVRS
GAQAVSLPPLLVLLASLVFSIAFGGPGAIAFPIAALLWCAWTYSPFLVSLLTLTTGSTLI
VAVAQNLMHFSVPQSELGVTTLMSARLGIAMLVLGPLVVSCVSQANRSLLARLAHQATID
HLTGALTRSAFTRRANALLDSRQQHAQALPLTLMMLDIDHFKSINDRHGHAVGDQVLRQF
AHTLQDQLHEGELLARMGGEEFVILLPGLAPDRANFTAERLRRAVQDLHLAQGDERLQIT
VSIGLDGCAGHEPAPGLDELLARADQALYRAKAHGRNRVELAEAQGAG
>A0A1S7LJF5|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MQRLAFTLQKFSIAQTLLAVFMLILILAGISIYLASDMLTQRSINKLATLEARQTSQLIF
QSLYGVMQKGWVKHDIDDVVGRIQHTLPSIEINLVRSDKVAEMFGESEYSRLQRTRSAQV
DQVMRSGQELLRAEGEMLQFIYPLIANENCLSCHTNVTKGYVNGVIHIQFPLEQLKLPLS
FALKNLVYIFGLLTLLLCFIQFIVFRRFFIQPIIQLSNHIHAIKHDEAGIKNRPRLDGSS
AWFRELQQLTDNFCNLMNGLSEAHTQLQEQSERDELTGLYNRRKFNKLFAHELTRGVRYD
HPLTLYVLDLNGFKPINDTHGHAAGDALLKALGHSLASSLRDNDLVARIGGDEFVVLAPE
LASEHAELFKQKLVTIVEETRAEYDGIPLRVGTSVGVASYPEHGDTPDKLFEHADDAMYA
DKKARKAGR
>A0A379KYU7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPHAKHGLRLDLRTLILVLCALTAVVMLCASYFASYRVQRQLLIDHALEANRVYAAKLAS
ITDAFIGSALQQLAFSASEQGRQLDDPAALQRETDRVLGQSMAFNSTFVIDANGVLLAIS
PAQLRHMVGTRMQSPGVQEALQERRALVSTPYLSAANNLVVALTQPVVDANGRYLGYVGG
SLYLRERNILNRLLGEHFYKDGSYLYVVDRNRRLLYHPDSQRVGTVVQGNELIDQLTNLG
NGTRQLTNSQGVEMVAGFATVPSAGWGVVAQQPLAQTMMPLSRLVLNVVGISAPLALIGC
LLLWWLALTIARPLWQLAAGARSMDRPGTAERLHRVRAWYFEAAELKRALLFGLNLLQAR
IGRLNRDAQTDPLTGLGNRRSLELNLSLLEAEGRAFAAIVLDIDHFKQVNDKHGHVVGDQ
VLQRLAELMRRCCREGDLLCRTGGEEFLMLLPGASLEVAAAVAERLRVTVQETPIQPVGA
VTLSLGVAHWNGEPGREPETVLSEADLAVYRAKQDGRNRVAVA
>A0A2Z4RG62|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MSLNACCRTSRPRKVIRIWILPCNKRCKRGGSPVWGLSVTPSDAPVRAIGDEQLAAIPGL
FRDSRTLRQDLILSRTLSQMFPAQYQAKRYIEHVLYVSTTGVVVAYPRIPDEKLPAVLKA
FAASRLIRPRAQSTSGADVAFMIIQARQVFLGARLLLTTSLISNGVPRGAILFEVLQQRL
QDYLYAGTPPDELHVLLDQRGSLIATNQETFNDQEGNWLNTLPETVSGLSMPAMFQSGKG
VLRGGDDLYFYRVLHDSELLLLNKVSINELRWSVIEQFSSIFIFVWLSLAALLVVTLFVV
DHLLLNQMRLNARLTELGLVDALTQLANRRRLQADFKGLVRRLQGKQPIALLMIDIDRFK
FINDNWGHTTGDEVLKHLATLCRALVRPHDLVARYGGEEFCVMLPATTLDDASRIAEKLR
IGIEQSVCLPDPVMMLASAPSREVHLTVSIGVAELGADQVTGLEALVAKADRRLYAAKEN
GRNQVVSDDHLVSD
>A0A2J7YKX3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MSQDTRPVPAGFSEQQLHTLFDLISDGIWDWNANTGYVYRNPGWYNMLGYASHSMANSVF
TWESVIHPEDYPRVMAHFEAYINQRNERYRIEYRCRCQDGSYIWIEDSGYVIAHNEDGSV
ARMLGAHRNIDAGKRLVTQLEQKNQSLEFQVAERTRELSWVNQQLQRQLDENRELAERDA
LTRVANRYRLESALQRECQRAQRFRQPLSLIAMDMDDFKPINDRYGHARGDAALVRVAES
LRTCLRELDLLARWGGDEFVIVLPQTALGEALDVAARLRQVLEQVEPVGDCRLTMSYGVV
QWLEGEDQHALLARADKALYRAKGTGKNAIAE
>A0A5E4U2T0|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MSHALPTSRDADSPHDSAHRGADEVTQAIAQTAHALWRTHGTTGSTSPHLPSDDRRGRID
AVTDIIDRESPLASTHRDMTASEADLHASHAPASTPRHGPIPGAPVDEAERLAALRRYEI
LDTPPEPAFDRIVRLASYLFGAPMSLVSLIDESRQWFKARQGIDTPQTPRSMAFCAHAIL
GDDVLVVTDARADRRFADNPLVTGEPNIRFYAGAPLRTPEGHRLGTLCVMDRRPRALDDE
KRALLADLSALVVDALELRRVNRVLGEMAMRDALTGALNRRAFLMQAERLFSAARAQQRR
LSVLMLDLDHFKRINDAWGHAIGDRVIVELTQVLRATLRKGTPIGRLGGEEFAVLLPEAD
AQRAMQAAERLLVAIGNASVPGPSGGSSGPIRFSASIGIGSLTPDDAEFGTLLQRADRAL
YAAKQSGRNRLAVM
>A0A379KQA8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MALDPPTMLTITIALAAAAALYLAIEWRSVREPSLLFWSAGFATITIGSTLALLRGIGLL
LIGIWFANGLLVVAHAFFLLGVLRFTQARLSWGWLLIVVAWFALLLLPVGPQWSKVMLMV
NSLLVALLTLKASLLLRPHGKSLSVGAVQLRYVLLIHGLFYVVKAVIAVTPGTLIDLATF
GGLIIQVSLVEGAMAIMLIALSMTGTVRYRREERIARLAARDPLTALYNRRALEVRATPL
LKDVSPARPGALLLIDIDNFKLVNDLHGHAAGDRLLVTLSEMIRAVLPERSLAARLGGDE
FVILLSDASSERVVELGGVLRSQFQQFAEQAMPTPQAVTLSIGANLFDHPPASLAALIEQ
GDVALYQSKRGGRNSIRLVDRSEMNPVR
>A0A837FRI8|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. SM3|TrEMBL
MPTSPLTPRTGNPFLPVHLCFLAVFLFSAFLTVHEAIELKNNYEARQRAQLAEIQKNLDS
QFQESIDELMFYEKMLNYALMHPLDSSQTREAITRFEQLRQQTTWQLKLASLRSMPLNGV
SDSWLARDPLLLRKNDQLIAELRAAMEFSFIMQFSDPAQDFHSRFWYISRAGFFISSRPP
QSPQELEESYSTMTQRPYFRDQAPNNPSHARLRWTEAYQGEFNEGLMMTVSTPIVSNGYW
YGVLSMDFTQSRIHALMAEARHSLLQGKLLIVDRSLKEITRLHAPNDEPLTPEQQARLES
RIRQLPGGVMRLGTQFASWSKLKNVDAYIVNIQSLRQGMSQELGRVSLFLLSMWLLFVLL
LLVAHQVIIRLVRRMDDLSAQLTWRANYDGMTRLLNRNAFFEQFVAISAHCQQQQTPLAV
IQLDVDHFKKVNDTWGHAAGDQALIRVAGVISHTLRKYDVAGRIGGEEFCIVLPETTLAD
AIAVAERIRTRLAAKTILVNCNSTFNITLSAGVTGSEEQGDYHAESLQATADRRLYLAKT
GGRNRVVAED
>A0A8H9NHF0|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MWARLTRRIRPERVVNICFLVVVLFSTLLTWREIIVLEEAYISSQRNNLKNVANDMDAQL
QFNTDRLLFFRNGMQSALQIPLAFEILRTAEQEFERQRTLPDWHISLNNNRTLPLNGVSD
AFVEHTHLLSRDNPLLSNEFMASIELGYLLRLSSLTRQHLSRFETHMIYVSRAGFYLSTE
HEERGSITEYFYKLATSPWFTAQSQRSNPDRGVKWLTTFNTEKPPAAEMVIAAVPLDFQQ
YWFGVLAIQLSVNEVTQFLIQSVEGEDDGEYQLYDRRMNLIASSEQLPSRRTQLSQEIQA
QLAHAYENDNEGSVRQVSRFISWEKLRNFDGVLLRIHSLDDGIRGEFGSISIALTLLWLL
FSSMLLISWAVIRRMVRNMSSLQDSLEWRAWHDMLTRLYNRAALFERAGKALEKCQHNDQ
PMAVIQLDLDHFKGINDKYGHQAGDRVLVYIGRVLMNKLRKHDIAGRVGGEEFCIVLPDT
SLEEARIVAERIRESINSREILIGKKQTIRVSASLGVCCSEELLRYDFEHLQSIADSRLY
QAKKSGRNRVCTED
>A0A0T9UFU8|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMLCVSSVLYTQNAPLWLWIMLALNGFVWP
HIAYLLASRSEEPFEQEILNMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFQPETSPLQVYACLPMIIVYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQEKLADIVF
AQAPSLQLKVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A2N7QUW8|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MHHPFAKQQRADDPNHRHEYMHYLAQRMAPAIHALALLAVVAYPLAAGGRALVSASPVPL
PLRLAPTIPLAVLALVTRRERRPIPLSLLALACVLILEIGINLNGIGQVPGQRLVLPGLL
LPVASSVIWIGRWDFIAAMLLCALGPLPMLLMGSVNGIPVFQYAVYMTIAISVAAVLRAF
ITRTLFEQFRLEKQLREQAHTDGLTGLLQRNRFLELARFALEDIYLRRIPGAVLYLDADH
FKQLNDAFGHAAGDEVLIKLADGLRSQMRDSDLAGRVGGEEFVMLLPGATLQHAYARAEQ
LRETMRAVHRPDRLLTISIGIAQCNRAGESIESLISRADKAMRQAKDNGRNQVVIDHFAA
KQHG
>A0A5D4Y5P7|diguanylate cyclase|EC 2.7.7.65|Lelliottia nimipressuralis|TrEMBL
MNKQYQHVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWETLSFWYTAINVIEACVGALLLRKLLPWYNPLKN
LSDWIRLAIGSAVVPPLLGGVLAWLLVPSAEPLRNFFVWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLLTMAVTLVLCWVSITFLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMMVSLMIATKPALLTPQNTDVMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCQFLGYSQPELQALTFQQLTWPEDLNSDL
KSLEDLVRGDINSYSMEKRYYTRNGEVVWALLTVSVVRHTDGSPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLQPDVISWDKRMFEMYEIPSHIKPTWQLWHESML
PEDREHAEQVIRDALMARVPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDIDMHVTFMNPVAEKMSGWTQQEAMGQPI
LNVLHITFGENGPPMENIHSGDMSRSDINQDVVLHSRNSGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVHDTHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRIIHAINDYHFMWEGRLHRIGASAGITLIDDTNSLAAEVMSQADIACYASKNNGRGVV
TVYEPQQERIHSARSMMSLDEQWHMIKDNHLLMIGRSVASPRIPESSNFWLVSLRLWTSQ
GEVLEEHAFRSGLAEPDLLHALDRRIFQEFFRAFAVQVANKGMGVALPLSPEGMSSSTLV
NELLDLLEKSPLPGRLLHLVIPVETLQNQDATIQDGLQKLRQAGCRIILSQVGRDMDIFN
HLSAHMADYLLLDPELVTNVHGNLMDEMMVTIIQGHAQRLGMKTIAGPSNQPLMMDTLSG
IGIDFIYGDSIAEPQPLELLLNTSYFAIN
>A0A839ZVC0|diguanylate cyclase|EC 2.7.7.65|Phenylobacterium haematophilum|TrEMBL
MSARILVVDDIEANVRLLEAKLTAEYYDVLTASDGPTALAIAAKEKPDIVLLDVMMPGMD
GFQVCRRLKDDPETRHVPVVLVTALDGRADRIAGLESGADEFLTKPIDDVMLFARVRSLT
RLKMVIDELRDREASGRRMGVIAGAASRLGGTGGRILIVDDHERQAQRVATELAIEHRPI
IEADPEKALMTAKGPVDLIIVNATARSFDGLRFAAQLRSDEATRHLPVLAIVDFDERPRL
VKALEIGVNDILPKPIDPQELAARARTQIRRKRYTDYLRDNLDHSLELAVTDQLTGLHNR
RYMTGQLEALVRRATHGGDPVACLLIDIDHFKKINDGYGHDVGDEVLREFAVRLASNVRA
IDLPCRYGGEEFVVVMPDTKLEDAERIAERIRLHVAGSPFRVMGGSELLTVTISVGVAAT
LGESDKPEALLKRADEAVYEAKAHGRNKVVARAA
>A0A3N6HIM4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI96-02|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVTGLGYELGCVNLVRPDGD
LVIAAFAGNAAAEALITGRVGSRASWERRLSMGEAWDQLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASGGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAVAEMGGDQHGRLLR
TNDALCRLLGRPASVLRRYSFADLVHPEDVGTLLRTSAEGGRAELRLARRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELRSRLAARLCER
PHSPTASAVEALDAAYGGVDSAPAHGYQPDGYEGYDGYDGDTMPGDGPFDHHVHAVAPYP
EHGDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEF
VVLADGLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTAEEVLRSADQ
RMYVEKRSRSKVHRRAG
>A0A377J820|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MKKPDIPANERQRLQSLEHINILDTVNEERFDRLTRLTKQMFATKIAAISFIDTNRQWVK
SAIGPLDKEIPRDITFCAHTILAHTPLVVQDTHADSRFSDNPMVNGKPGIRFYAGYPIRH
RNGALIGTLSLADDEPRSFDVDEINCMKDIAALVENELVSMQSCTMQDPLTGLLNEDGFE
VLSQNSLNMCERLNLPASLAFFDLSGITRINPLPKRERDNAMVFFAELLKFGFRGSDVLA
RLEHGKFAVLMTNTPISNTQDILNRFKKRVERDAKEKSLLYTLNYSVGVSWVEPEGEYDI
SHLVEIARNLARKAKV
>A0A377HJE7|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MTVTSIDVLDSVVDITAQTESDTISESLITTVLQLTSANQVLVLDYNAEANPQFMVVACS
DIFLFEEEKDAIERVLRNCVLSGENVVEYCTDENQSLLASPIRYGEKDEIHAIIFCKAAQ
LKGDEVQLIEGLAKIYENYQKIISASERDGLTGLYNRKVLTTKIDLLLDRFLIQGTSIID
DPTHHHWVCIFDIDHFKQINDALGHVFGDEVILLVTAMMKKIFHDEDILFRYGGDEFVVI
MHPQSREEMEATVCEFIDAVNKRDYGQAKEVSISMGAAAISDQELNAITVLGFADQALYK
AKQNGRNQVAFYEDLIASGDLKSLKPKDDVELF
>A0A377HKB9|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MSNFSSDEDIILLKEKLQHYKLVSRDLALKSRREAMILKRLISRLIVASRVNDDDRLNER
LSQICRELDSQEDVSRLIPQLALVERMVSRYNQVTERATDALECQFQQSGETLKCLPGLP
AQLKRDLRTLLASPAAQQKGSTEKVVSLLQLYERALKLLSLPANGMNARDLLNIDRINQL
CTELQHLITELDFDGEVGDRLLDIRSKLLLSPNAQTLLELTLESVQLILDGTRNERKASR
VFLSQVNEDLSIVQRHNGRSIDCSLAITSQRNALNEELAASVESIQYHLKEAETLEDLRP
SISEVSVNLASLVTRNRALEEREQQLLEKLQYNEQKLEALYQQTMDYRKRLGDQERKLLL
DPLTKVYNRAALDDRLEHEYRCWMRYQTPLCLAMIDIDHFKGVNDQYGHLVGDKVLKVVA
RTIHQCLRDTDFIARFGGEEFVVLLPNTDGETRNVLLNNVRETIAKLPFKFKDNRLTITV
SIGASMFKDNDNTVDVLERADNALYNAKDNGRNKLILA
>A0A5W9FGQ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREMMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWLLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1G5SIE3|diguanylate cyclase|EC 2.7.7.65|Nitrosomonas mobilis|TrEMBL
MSLRDERKTKLDKLRKQAEAKLNRELSTKKKVLPEDTPRLLYELHAHQIELEIQNEELRL
IQQELLEARDRYINLYDLAPVGYLTIGANGLILEINLTLVRMLGMERHLIIQKSLSTFIA
ESDQDVYYQFNALIRKTKKPQNCELRMSKYNCESAKRDTHEADRNEKTSFWVQIMSRPLL
GDNGEIHTINLSINDVTEFKQARDKLKHLATYDQLTLLPNRYQMETELKLRINAAKRFNE
KLAILFIDLDNFKIINDTMGHEYGDILLKIVANRLSSHLRDYDTVARFGGDEFVLLMPQI
HDNVEVVAIAEKIISEFSNAFYLKERESFITTSIGISVFPDDGTTVGELLKNLISYLSQK
FSIYRSEEVLSLRRAAIAAPWQPNQNGD
>A0A1F2PM17|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MIDKTFKDTKKTILYTLGVFLILSLGYFLITLVIQINADTAQKNKLLAQQQQLVAVEKTI
ISNKVNRLATDLLYATDALALGDNGRGDYSDAEDHWLAFANRKMIYDQIRFIDVDGNEVI
RVNYDENGATLTDSDDLQNKADRYYFTAGINLAQNQIYVSPLDLNKENDQIEQPIKPMIR
LATPYYGARGQLLGLVVLNYTANDLLAQVEKIATASQGQVFMLNADGYWLYNSADPNRAW
GFMYDNRLNDSFKTDFPEVWSTIQSQKNGTLTTTAGVFAYTNILTATELELDLHHTLAPG
LGDWTMVSFIPATTPEGQLLTRSLAATMLLVLRYNLFAYLLILTLAVFAGVILTINQVKN
DEIKYYSEYDAMTGVFNRRTGFEKLKQLYKNIEKNEKLVSVCFIDINGLKDVNDFLGHDA
GDELIITVTRGIQNNIRSNDFLARLGGDEFLIIFEGLDEAEAEAAWQRIVAEYEQINATE
NRRYLISASHGIETISGSSNEYIDSIINQADEKMYREKKILKKNLKIVRDYVPDDKAGSP
E
>A0A174JD53|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MRKKNEITEYVAAALIFVCAVAVSLGIFLVCTQNSIERNSQKVIKTNVSRQSEHIKAILD
IHYGYLRGIAKEIGKSEELVSDENMEMLISLEEETALERTALIEADGTAHYDNGAEKNVS
LRRYFKEGMEGKETLSDPLESSVDKETRVILGVPVWKNGKVIGVLGGSYNVTALSRMLFN
DFFEDVGYTLITTSDGEIIAYDGDFAYHEIEYGDNFFEFYDDQTLIFDSSLTEVKKDFTV
GADGLMKIRIGNDYNSDRYLAYTDMGLNDWMICYVIPVSEAQKSYNFVRRYELIFTIGFC
VMVSMLFLWGFVKNRSKDKQLIQAAETDALTSAYNKRSTEERIHNVLQEHPQEPGTFVIM
DVDHFKEVNDIYGHITGDKVLHKFGEVLHEHFREGDIVGRIGGDEFVVYMRKTDSREVAV
SRIESLIKKVEELSFTEMNGKNITISAGMAFAPEHGTGYLDLYKNADTALYKTKQNGRDG
YNIYEEEKR
>A0A1C5T3I0|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MQTNKKSKNIIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREVKLE
ITGNQNEELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAARN
KGYENTDIVNMSEIYFSMADETVSSAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
RAMQMAMQNRLLEQKAFIDAHTGLPNKNACNELLNKKDIITDPTACIMFDLNNLKTVNDT
MGHSAGDQLIINFAKLLRSAIPEKDFVGRYGGDEFIAVIYHTSEAKIKEILKSLNREKDR
LNSYENQIPIDYACGWALSYDDMSCTMQMLLDAADAYMYKNKQICKKYN
>A0A1C6HIZ6|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKIALITDGWGRYVTYTWIQGYRNYMAAHQSDMDLYIFQSFGNFSMDEKHNAGEYNIAR
LPDFSEFDGILLDLATVSQPDLIAEIIERAKLSNIPAISLLEQIPGLYHSGIDNYEAISR
IVEHLITEHGCRTLNFIGGPEFNRENQLRFKAYRDALLRHGIPFEEQRVIHHNYEIETGI
QAFSTFKEKNLLPDAFVCVNDNTAVGVCLAAKEAGYSIPGDFLVTGFDNEDKASYYEPRI
TTVGFSKADIMENALLMLEKIWNGNAEETYIYAPFTYVFQESCGCVSQNPPDREEYVIKR
IVAEARQSDMQNWMMDLNRVLLDCSGYTELAGRMQNWLTKHGCGNIYLFLNPDIFMSENM
DALPELPEDTYQTEGYPEEMSLVYPPLDGTNRLQLNLKEILSLPQAEATRGQNIYQFCPL
HFREREIGFLIITNCDYLLEHQFLFETLNALQTSMEALYARLTLRKMNKQLSQLYIHDSL
TGLYNRMAYEKLAMPLFHQCMQENQPVGIMFVDADHLKYINDTFGHDMGNLAISSIASVL
RQHCPAESVSIRYGGDEFVCVIPDYNKQKIQELAHTLQDSLEVFSANSRMGFPIEASIGW
VIADDPGLTLNDYINLADEKMYSAKKARKAERKI
>A0A1C6H389|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MEKSVKDNPEYKMKRQGMIIGLVCLAVMVFLTIFLMSRYRQRTEKIFTELMEESLLSTHS
EALTEMENFLAGSTGADKVEEAWEALNEDEGNVLHYVCNSDGKILAGDMRIFDIEYTVAT
VLHSQHVKDNSISQVEKSLKKLTYGAPHIFTELEKTDIYLVASKLEGRDCILFSEYRSAK
MKNYKAILINGNRMIIFTLLGCALIMLLFTVRFYMKQQKKVMKGQARYDILAEFSDTVLF
EYDCLEKTLVFTPNITTLFGLKEIGPIRPFDSDIDFTMVHPDDVAKVKALLSTIGDNSDE
IDDFVIRFKDKNDNYRWVRWMGRLIRGRLGTPQAFLGKISDVQDEMIREQDLREKASVDG
LTGALNRKAAEQKINTLMQDKDCKGYLLMLDIDDFKTVNDTMGHAIGDLALITLVKLLKE
HFRRNDIIGRLGGDEFIVFMTNIELASAVEAKGAEILDILAKSETTPHFTVSIGAAAYPA
AGNDYESLYLAADNAMYASKKSGKNRIHVDNGQQKKE
>A0A1C5WA93|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MLDEKVLQVAILIWGCVFCAIAAICIFLSSNYDREKRRYLILMESFASMLLLMDAMAHIF
SGYPGVPGSVMVRISSFLVFLLSDVVLLCFHIYVCVYLFSKRERRTLKRVKAGYVIAAAG
AVFVVISQFTHWYYYIDGDNCYHRAPLYIMSILLSAAGLLIDLTLLLQYKKRVSRKLLFS
MLSCIVLPAVAAAVQAFWYGMSLIEFSVGISMIIMFIVTMTELNQEMYELISREGKIKER
LEIATILNKCIAELISGEDEDAAISNLLRIISGYFDGDRSYIVQIDEKRNVCTNTYEYAM
NGVTAEKDNLQEVPMEMLDIWMDSFRKNGLYYIPDIEEEQGQPYYETLKMQDITRLLAVP
LNSDGKIIGFLGVDNPRLHYEDHTLLSSIQYFLTDSLKAKERKACLQYMSYRDMLTTLYN
RNRYIQVLEGMQAKTVIKTGVAYIDINGLKRVNDLYGHEAGDRLIINTARSMLAILPENA
YRVGGDEFVLICFDMDEKIFRSKVRDICDSIAAKRISVSVGVVWEESSSELETMLRRADD
LMYAEKKKYYEKHGTM
>A0A1Y5T6X8|diguanylate cyclase|EC 2.7.7.65|Palleronia marisminoris|TrEMBL
MMFAGDITLDPGVLGQLLPMHLRTELSGRVLSMGATFARIAGSRATPDMWLFDLLACELP
DGEVEVAPLVGAPVVRLRFRDGRRVGFRGHAVALPDGTALFDLAFDLVDLADLGGARLTA
SDFPPTDRTLDMLYLMEAKSLAMREALRLVDRLQDARDRAEAAALTDTLTGLQNRRGLDH
VLQRTSLGTPFSICQVDLDHFKRVNDSYGHAAGDAVLRAVARRLMRNVRTSDTVARVGGD
EFLIILPELTDIAVLDEIALRIVAELERPVVHGGQQCRISASLGIAVSTDYGYPDVKLMI
ADADAALYRSKSGGRARHTIHARPEQAPAPPGPPGTSRRSARP
>A0A6F8SZM5|diguanylate cyclase|EC 2.7.7.65|Halomonas meridiana|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKAINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVAAVTE
>A0A1N6D023|diguanylate cyclase|EC 2.7.7.65|Halomonas meridiana|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKAINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVAAATE
>A0A853W3S1|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MLKGAVSAFKKRLRKTDCLARWGGEEFVILLPETGVEGAATLAEELRQKLSEMEIPGVGL
VTASFGVTGYRPGDTVDTVTQRVDSALYRAKGNGRNCVCVGDPD
>A0A174B5P8|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MDDLEQYKDRLRIALSSAKICIFEVDLLRQLYTFFENAEDIFGVSGDSILKDVQSYSTLA
PEAYRLAVSKYFSHPDDSAVIEAAFAQILRGEPATYEARMKAGGSAFIWCRISVTPIIED
GKPVRMVGVITDITDLKEKTESLRRAVNLDSFTGLYNKDHTIALINNILDMGTHVKHALV
ILDIDNFKKFNDTYGHDQGDKIIKALSQKLKNTFRKTDIVGRFGGDEFIVFIQNIEDDQW
LRDKLHHLIRFEAGTFTCTSSMGVSVFPLDAANFEMLFKKADIALYHAKSAKERAVFFSD
LDRNEKKDSLR
>A0A7W8LPL2|diguanylate cyclase|EC 2.7.7.65|Deinococcus budaensis|TrEMBL
MLFNLSLLVSCAFLLSLSYHEWPVRRRRAEHVLRVALASGASWLLMMYALRLEGFRLDLR
YVPVALVTLRYGPLAGALTLLPALLWRAAEDLHGGLATALSGLSVVALTGALRRRLPVTR
PQLRARDLWLAPVPFLGVGLPLLLTPQGRSVAALYYPLGVLLSAAGAVLALGILHSRLRL
LSLAHTLRTQARTDDLTGLSNRRQFDEDLAALDPGTQLVLLDLDHFKRINDTHGHAAGDR
ALEHVAALLRELDPAHLRPYRVGGEEFALLADLGAESRARAQVEALLREVPAAGRGMWAG
LTLSAGLATRRPGESAAALFRRADEALYLAKTNGRGRLVVWTPPDGSAARAAELGAGAPG
TELAGQGWPGPGLPGSGPIQPRHSVWQALRTTVGLLAERRTLHDEDWTEVLRLAVDAVDG
AVGGSLAIREGRGFRICAAEGYGPELMGLTLSEASQQRWYARSPSAWRAGRPRVLRGAEL
QAASVSSGEVLEDGVVRALEAAGRGGEHEANLCLPVVLGGEVVAHLNLDARGPADAFDDQ
STEVAELFARQIAALLDLQERWRELGVLGELHLRVGAGRGGAVSVDEHLSQAAVDLLRAR
WAVLLRYDPAGDRLLSSGAEIAGGDLGPVELPRGEGLAWAALREGRTLRVDDVQQHPGVY
RRAQLGHQAMLVAPLPTHHLEPLGVLVITREAERPFLPADEHLALMLASLAARLLERGAH
VQDLRATLEAALNTLGFALEARDFETQGHTERVQAHALAFGQALGLCAERLLGLRQGAAL
HDIGKLGVPDAVLLKPGRLTPQEREVVEGHVLLGAALTARIPFLHPEAIGVVRSHHERWD
GQGYPDGLKGEEIPPLARLFALCDVYDALVSARPYRPALPPAEALALLRAGRGTQFDPHL
TDRFVELWQAGAFGSVRHAGTGAPGRRTDEAEAAPR
>A0A1S8PHP3|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MFRIILKYGIILDRLVNFKLVKKRDELELRNVNNNYLIEHEIVIEENFSNYIVTDTERDA
RYVLCILKNGFTYEKTREYLLSKFKTIKNLNFENVTNIINIEIIYSINGIKLDTPQYGYL
MEYVEAKLDTQDYFNKCDFHKKLDTFMEICAAINTLNMQGYIFDDISMKDVILIPDSNNN
VKVKMKDLLANELRKFNLINSLPYQYNIETREDINSNKDNIVQVAELCRQIFTESELETG
FKGLEDIKNIYNRVNTINKSFKLKYFIQNINKKMKKNYRVFISEALNKIKTDLDIIGMTE
EIKIVEKNFQRILENKQRNKFINFNGEDGSGKTRLLEEIKYRFENKYFKDIIYIDDFNNK
NASNEEQYNTILNYILNKVDKNLRDKYEIYIKKFISILFEKNSTNSENNKQKLQLINRMG
KFISEYTMTKPFIMIIDDLDKKNEVFKLFIKYIIFLRNNLENVMIIFSMNESSVDENFIK
FINELKQVEKYEEYKINYFNQYNTTKMIRSMLNTGTDVNKLAVKIYSETLGNPQYISGVI
NELYGNGTLYFDSNNGEWKTNIKVQDILIPKSLERRLEASIFSLNEEEINILKELAIFKT
PLSEKIILEYVIMDSDNIEIYDNLKSKGILTDKISDQGILIGFRNNLLRNILYLKLSEEE
RIKLHSKASIFMEKILLDTDYYIEELLLHLEKSNSYEKAYFYTLKYAEAQDLLGDISKAI
SYYKKVLTYPSDSSGSEVAIKIAKLYEKKSNHEKSFEHFEKANQIAIQNDEIEIEIYTLL
EMIIIKINSITDIDTGIDYSLNCVRRLLDKEHYPKGEVYYYYALSLKYRLEYNNKLTMLN
AQKAIIICEENKIKEDVYGWAVSILINIYIKKGNYKEAKNLCLYANSIFINNNNINGQLY
IKLLDASVCKEEGRDNKEILEQYLEIAREGNKQKVYKREILSLICIADIYSQEKRYLEAE
KYLLRALEREREEGIDSYSFNICNELCLLYIKSGRISLVVKYHNLIMQMQKGLKLLEDRI
INTNYTYALYNLMICNYDLAYDHLKKIYALIFNSNSSKYKIVVCNYFELILYKCKNESDI
RNVYNKLEKKIKLLQDVDTCLEIRISAIRRILTLGYKGLAKELFFDLNGYPKNYNVEGIY
VYLELNFRNRNQYNFLINKALRVCSFVDNQEIKADIYSAIGEKYNELECNVLALNYYYES
IALYIDTINLLPQNDKLSYANNSRFLETRKLFVKCLNEDLGINMSFKSTQFIKTIEDLEQ
ILKELDLMNILDNEDTFKLVQYLYEKCYYNDFRDIFKVFEKFSNNTIDDIKNVMKYMARL
ILADKAMIVTENEQGENDVICTYRISDKNEINRYLSLKVDSDEDTFAICSNDPRFYQLDD
KVLKDGIRSCMYMKIINREKHINSSAGINARLIFITNNALNYINNESKKTIEKFKPFLTF
LLEKYNLTISSTLDKLTGVYNRKYFEEALLFLLDSAKARESEFAVMMFDIDDFKGVNDKY
GHQTGDEVLVKVADEVKKCMSKGDIIGRYGGEEFIILLPNVNCEAAINLGERIRKNIEEA
RILGDKRKVTVSIGIAMSSYESLNNEEIIRRADQALYKAKRDGKNRCIVWENECGASGNT
NDELTGVLSGNAAKDYNFMLMLKEIAGIAKRRCSKEEKIYNLILKIMQTIECDVATIFIV
KEKKIVNTYSKRRNKDNWNLDDRFNFKLVNQVIEEEKGLYLVDWESMDSHNSYGLPDWKS
VCIAPIICNGELLAVIYLSISVNEKEFICNDYNVLNFLIEIGSSIFLG
>A0A3S4IGU6|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MIKKNRQTETARHSLILLFGLGLLCFIFTFYSMELTLKGTDLVPIWFTTAIITASFFRNP
VRQWPLIAAACMLGSLAASAMLYPLSWLSVALTLINLFEALLGALLLRRFLPRENPLQNL
NNWARLAICSAAIPPLAGGLLVTMLTVPLDSSALKTFFIWALSESIGALALMPAGLLFKP
YYLLRHRKASLLFETVATFAVTLVLSYFSLLYLPWPFTFIIVIMTWSAIRLPRMEAFIIF
LATLMMVSAMIAIGKLPLSTPHPRVLEYAPWLPFLLILLPANVITMVMYSSRKERKHIIE
SETRFRNAMEYSAIGMALVSTEGKWLQVNKSLCKFLGYSAEQLGELTFQQITWPEDLNLD
LQHLSKLSSGQINSYSMEKRYYTSEGNVVWAMLTVSVVRHTDGCPLYYIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLTNDVITWDKRMFELYDIPSHTKPTYQLWLDSL
VKEDLLHSEAVIRESLKNRLPFKLEFRIHVKEGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNVTFMNPVAEKLSGWAQEMAIGQH
ILSTLRITFGDNGPVMENIHSGDYSRSAIEQDVVLHCRNGGSHDIHYTITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENHLKRLLQGAIEERQHHALVFI
DLDRFKAVNDSAGHAAGDALLRELAAMMLSMLRTGDFLARLGGDEFGLLLPDCSTENARY
ISERIIRSINDYHFMWDGRLHRIGASAGITHIDGDNAIASEVLSQADIACYASKNNGRGQ
VTVYEPHNHSMEQGRDTLSLDEQWQVIKDNPILMIAMAIAPPRTPESTSFYLLTLRFWGS
EGDVINETAFRAGLADPALHHALDRRVFSEFFNNFADEVAKKGFGVALPVSCAGLVSDTF
VDELLDRLSTSRIPPRLLHLTIQSSDLLTEPKRIYTNLKRLRKAGCRMVLSHVGRDLALF
NTLSHHLFDYVMLDPDLILNVHCNLMDEMMVTIVHGHAQRIALQTIAGPADMPLVMDTLS
GIGLDLIYGETIAQPQPLELLLNNSYFGIN
>A0A7L6PH87|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00127|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A5S9R3P4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MARIQRWWSDPDRFEWTTQFLTDRGLRRSAQWMMAILSASTALITASSLFALNLPAVTGY
ALIALFAAFAAVMTAFWLTRWPTRRQSAQAMGVGILFISAWSLVQTDTALAVLGCTATTV
TGGYVAFFHNARLLLFNLAVAVATAISVCWRLSIQANLATAVAAFCLIVFLNVSVPLAIA
GATRAIGTYAMRSDVDPLTGLLNRRGFTDVVVRRLGNGAPTAGNLVVAMVDLDAFKNLND
SEGHAAGDRALRAVAELLVQEGPPDSAVCRAGGEEFLIAAIGSVEPIAGAVQRVCAHIAD
LPHRVTASVGISSTELDRIPYNDGMPLIDQLIETADTAMYIAKRNGGNQVHRA
>A0A554WHG7|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MTIPIAVAVLATTLLVLGWALAAWAVAQWRRALRDCGAATEALTQQQQVSQAVAQVLQAA
RVALWEADTRGVFTRVDDTAARLMRVTTTDLVGVRRVADTRDADHRDALAQRLADVLRTG
RPLVRWPNLVVTAQGEPVWVSTTVVVRRDAQGRPVGLQGCDQDINTRHRLMLSLQAAERR
HRLLTEHAQSILYTIDSEGRLTYVSPSWQALLGHRPDEVIGRDFRPFVHPEDVPLCEDCL
ARTLRERRVLPPLTYRVWHRDGSIRYHRSVLAPVFDDDGRLQTVVGNATDVTTDIELRAQ
LERVATHDALTGVANRRLFIEQAQREIERNRRNGAGLGLLMLDLDHFKDVNDTHGHAAGD
AVLIAFVQRCRAALRPSDVLGRLGGEEFASVLPQVSLEQLQAVAERVRHEVARQPYALPD
GTVRTVTVSIGAAVALPAEDSDALLQRADRALYAAKHGGRDRVVLDPTAPPPAPAALPPF
PALTRR
>A0A8F9UTP7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MNVSSATPRTGKIASNTERLLILSSSLIVVAILGIVTYLLIREHAAAEQAATRAANNIVQ
LIDADVLRNVELYDLSLKGLISAAQRDDLKDVSASIRHLALFDRATAAPYKGDILLLDRH
GDVLADSASVVPRTGNYADREYFRSHIDNPDPRMMISPPFRARTADHDWRISFSRRLSDE
HGQFIGVAEAAMRLSYFNELFRNLDIGRNGTINLVSRDGVLLAQQPPLADDLIGKNFSSR
PNFVRILREGNGSFSSVSSVDQKQRLYTFSQVGDLPLIVIVALSIDEVFGAWQRTAVLIS
GATGALCIALFWLTWQLCRELRRRQSAEQELARLAAVDALTGLANRRTLDQVLGNEWSRA
RRANLPLSLLMVDVDHFKSFNDRFGHPLGDQALRAVAQSIGACVGRPSDLAARYGGEEFA
VILPGTDSAGAAVLAEKIRTSIAALPAISEHAAPLTVSIGINTWSGNPDIGLEQWVSDAD
KALYQAKYSGRNRVVSNMSQGGSKRGA
>A0A7R6WAQ6|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MLFISREIILEEDLTTDLMVLQSHLDGMLERVKSNSTTLRRFQMFEMGLLNLNSLAEMLE
YVLGAQDFFDLDYIGFCLIDAKSELQSYLLEDGFNIKKQPRLIILDNNEVLQATFGCSIN
PYLGLYKTAKCADFFSINKHKPASVAIIPLVRRGKFLGAISMGSFDAHRFENTMATDFIE
HMTSVVGVCLENHLNYESMKRTSLMDTLTGVNNRRFLEQRLGEEIDRAQRSVEALSCFFL
DIDFFKKVNDSYGHQVGDQVLTVVAGTIREQLRNNDVLARYGGEEFVALLANIEEGMAID
IAERIRKKIKNIVVEAKSGSVTVTMSIGTVTYKPSKGSHVSSSQVGVDLIEKADAALYSA
KKSGRDKVVSAGVISDHMALANLFK
>F4NEP5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli D9|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWK
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVCASDNA
>A0A517YM87|diguanylate cyclase|EC 2.7.7.65|Anatilimnocola aggregata|TrEMBL
MDILTLGLPASVALAAIAVIGYCFGQRTQPVLSDDAQLRRELKRARGIIRDLEKVAQQVR
RDLATHQGSLGKFRSRLRDLTEAGEIQEHEPMGQLANETEKLLEPTQHLTERLAQAYELI
RQQANQLMSFSEVRTDNLTGLGNRKSLETMLASQLDMHRRYGLVCSVAMFDIDHFKHLNT
EQGLSRGDEVLKQVGQMLDQYARESDVICRYGGEEFVAVLPGTGLRGAVAFAERMRTTIE
KLSPVTVSCGVAEVLPQDDVAGLLSRTDAALYSAKAGGRNQVMQHTTHGVVPALKPETIN
STKGSITGRLVPTEAAARTTLSQVTETLRTRQFIRQATTSVVRDNSLLA
>A0A1U7DC59|diguanylate cyclase|EC 2.7.7.65|Salipiger profundus|TrEMBL
MTGRILIADGVPTNRIVLRVRLSSAYYEVAQAGSGAEALQVARRERPDLVIAATDLPDTD
GETLCRKLRGTAGLSDTPVILLHPAPDRATRLRLLAAGADDVLARPVDELALLARLRNLL
RARHAEDELRLREDTRRALGLAEPPRAFERPARIALVPVQADIPLRPALVTLHARQPHRF
EILDPEQALRDGPTPPEVMVIADTGSRPGAGLSLLTQLRGGPKSRRAALFYATRPDCRSA
ATSALDLGADDVLAEGFDPEELMLRLPRQIARKRSADRLRDTMRSGLRAAVTDPLTGLHN
RRYALPHLARLAERAARQHREHALILLDLDHFKQINDRHGHAGGDAVLVEVARRLTEGLR
MADLVARIGGEEFLVALADTDAPRALRTAERLRARIADLAIDVSGCGDLVPVSASLGVAL
ASRARQETSEELFVRADRALYSAKRAGRNRVVMADAPPVAAPAELVPDLPRAASARP
>A0A3Q8DVI1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. CFNIH10|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>Q8EGN0|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MSKTNLHNFWCFLLLFWTFSPFALSAEIALDSPYLFHAEAKQLPPADFKEVSQWMGQLKE
ASSVSLTGGDYWMVSPVMVNSRQTRWVVDASNSIIESVDYWLLGSDGSVQFAHSGYYAPY
EFLFDYGRKVRLNMGTDYWLVTRLSSQYFSSAPEVALESQEAHQLTTDRMAMAILLCLGG
LLFIAFYNLLIYISIFDKAFLYYGLYVLAYLGGWALTFHLPAHLFNFHQLELHHLFFISL
PIFNIMFYKHFLQLPSYSPRLWRLSQYLLIACVIALPTSIWLLPYTAIIASVLIMLWIAL
AITCGNVCLMKGFAPARYFIMAFTCLLLPAVIILPGNMGITPDFIEHAEFATLLGGTVDA
LLLSLALANKLKLMSEERKAHIEELGIAWEKARLDALTRVGNRYAFDEFMNSQLAFANKV
VNPMALVLLNADSLKMVNDTLGHQEGDRLLQRLVQFLQSTNIAQLKIYRISGDEFVAILP
ASGVTSFVNTLRGLTAQFATEGFRDCQFSFGIAINADVANPHEWLRSADTSLYHSRMEKR
RQEYADTRTGEIVSL
>Q31V96|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEA
ILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPA
NPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAR
ELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLP
NKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRM
ILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDL
TAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQP
QVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQ
ERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAIL
RPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLA
QSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A380W766|diguanylate cyclase|EC 2.7.7.65|Afipia felis|TrEMBL
MLNVVTLWLVFVVNFIALGVVWTYVARSYPNFEAARFWAAGALVASAGAALSVLRMYVDP
VAPLYLGAVMMIASTCFVAMGVERFYGLPVSWRTHVALVGLCAFGIAFFVWHANSPMRII
IYSLGQALSIAISVMLVWRHGARHPGARFAGVVGIILSAVVIARCALRLSQPPDNIYMIH
FSPLQSIIVLVLVFLSIVWNFGFLLMAVDRLRAEVADLALIDDLTGVANRRRLLTSLAEE
CARSDRAMQPFSVLLIDLDGFKEINDSHGHGAGDECLRQFTRMIQQRLRTGDLLARLGGD
EFCAVLPATASHEASCVARDVLDLCASAQVFWNGTTVRLSASIGVAQWRPEIGHDFSRLI
GAADEALYAAKRDGRSRYTVSALSSETEAWMRQSA
>A0A0T9P543|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MTELESLSTLYRDACVTYATLSISYFALSRNSAFSYKGEVWKRILFGLVAGLVSLYLNQD
QWILFGAFSYSFELIPIILVIFYGGWLSGLTALAINFVFTGWMTTGNILILIVFTPLLLS
KVWEKKSNRIFYITIILIVAYRIIAAVLLVPHAFSWAQILVYQLISALCLAICYHALNFK
ERHIHAYFAMKNRANIDKLTQLNNRASIDYRLMAINNSRQACGLMILDLDHFKAVNDTYG
HNAGDVLLTEVGKLLANTVRDEDFVGRYGGEEFIVITHRHEPQAIKTVAERIRQRVENLE
VMLPDGRKIKATISIGASLYLPGMSMLKALKMTDEALYQAKNQGRNRVAYSRLMPFSPLG
DRIVKDRRRRSL
>A0A178X599|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MPGTEPARGDRRGPGEEPPAATGFAGRLRALIAANPVSSWDLWTKPRRMVAFLLAWDAIA
VALLTVGVVASPSPDFVDWGRFAILAGCATVHIQLTRRQEERRRNRVTAVHIDLTGIWVF
PAALLLPIPLTLLLIALLRIQRWFNSRRPPHKFVFTSFTHAVSALLAHLLYQTFASAELA
RLSPANSLQVFGILMLVGFSYAALQAIVIGGLLALGGTSAPTLRNVLGTKDDNLLELSTI
SLGTIATILLVNIPPAIVILVLITVLGNRLAEINQLQSEARTDPKTGIFNVRGWSESAER
ALARAARGGETLALLMIDLDHFKWINDTYGHPAGDDVLRTVAQTLDEITRPKDIIGRFGG
EEFLILLPDADTTAAKVTAERIRTAIADQRIVTTDKRGGSALISGRTASIGVALLGVNGT
TLEQLLQAADAAVYTAKEGGRNQVRFADANLPSE
>A0A0H2YZY5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O1:K1 / APEC|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A156DUB0|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MSQNGFEALNVIKTPVWLISPVSEEIIFANVVATQLMGDKTLDQLRKGIYSANAQALLSM
YVPELKTEQEIVEIWTIRSRDGLDTPLSCRLSLARYAPWGDVIVFEGIAQHILSGLKASR
SATYRRKKQGFYARFFQTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDGMCSKHTWEI
NTLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDI
TEQKRLEQELEHAALRDSMTGLLNRRQFYAITDANNLNNRPAQQQFSLLLVDTDHFKNIN
DLFGHLKGDEVLIALSRTLEACSRENDMVFRWGGEEFVILLPHTSLDTALQIAESIRAAV
ARITIPGLPRFTVSIGVARHNPGETIDELFKRVDDALYRAKNDGRNKVLAA
>A0A7D6YAR4|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MMNDETYYNTKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWAFVWPHFAWQLSCRAASPHQQEEFNLKIDAIIAGLWIGVMGMSALPTA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPIVGRVAVFNPDLVEWSLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVYNRRHWEMLLRNEFEHCRRDRCTATI
LLIDIDHFKNINDTWGHAVGDEAIIAITRQLQMSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHERLEKLSLPCAPKEALRISVGVAPWGPQFAHYREWLKAADVALYRAKNAGR
SRTEVAA
>A0A156HJJ1|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MKAPATPENETDRLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGKAPDTVPRNISFCGHTILTEAPLVVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSVARRRAEPLTLGWLDLDRFKEINDRYGHEEGDKALKVMAQLMRSAFREADMLV
RFGGDEFAVLFADTGEQGAWIAMQYLAEQVESYNARKLHPWSLHFSWGLSEFDHNGNDLQ
QWLKDADEKMYAMKQQRQRAR
>A0A3N6I0H4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI98-10|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVEGLGYELGCVNLVRPDGD
LVIAAFAGNAAAEALITGRVGSRASWERRLSMGEAWDDLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASGGGRDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
TNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADAADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICER
PHSPAATAIEALDAAYGDVESSLTHGYQADGYEGEVVPGGGGPFDHHVHTVAPDPERDDG
TKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLAD
GLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVE
KRSRSKVHRRAG
>A0A3V8KQG8|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7U8W5M1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli FVEC1412|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTE
PQVTVSVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A238IVX2|diguanylate cyclase|EC 2.7.7.65|Boseongicola aestuarii|TrEMBL
MRPEKYLDRILTFVTPKDGINFLSKAVLVNAAVVLAFFQIEILVHDADTHHAAEHVLATL
ILSVPFSLIALAAIWYLNTLRRDLAKLAATDLLTGLSNRRAFMSASENATSQSRGIMMMI
DLDHFKQINDTYGHTVGDDCLRAMADVLREQVRTNDVVGRLGGEEFGVFLVDAPMEAAQQ
IGERICAGASLTLSQADRDVKVTASIGAVEMPQFEDIEAMLTLADMAMYQAKNAGRGCLV
FWEKGVTARAQAECV
>E6WRR3|diguanylate cyclase|EC 2.7.7.65|Pseudoxanthomonas suwonensis (strain 11-1)|TrEMBL
MAARSGSPTAAPTDPRLIADWTRRLQSVDPAVAHLLHGLVAELAPALADHFYDGMLQDPR
ANRFLDPGQVQARLKPSMQRWLHQLVQADAAAVEALHQLQEHVGQVHARIGIPVDLVGRG
MRLLKERMHEGIASGAGSHAEALAASLQLDGLFDLALESMTRAYTRSREAAGELDGSFRL
FSLIQNVGTERERQRALLLAWENTLLYALTAEQPGPLEGLLLSRSEFGLWFLHKGLASFG
ETSETRQVGELAERIDAALRERLPPATSAAGRRVLLDDIRGWTAAIRDLVGILFEGIGDL
ESGRDALTRLLNRRFLPTILRREVALQASTGRQFAVLMLDLDHFKAINDGHGHEAGDRAL
QHVAAILVENTRGSDYLFRYGGEEFVAVLGSVSQTEAVAIAHALRRAISGAPLALSDGTR
LQLSASIGVAVQDGHPDYERVLARADAAMYQAKRAGRDRVVVADGPLPEPPGHHAGQD
>A0A8F7ME08|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MARHSRKLSFTMPILIGFAGILLSFLLIAVFVTTTQRQNFLEDYHHVNRNFTHNLAVNYT
ESLLRGNDYILARATKFFANNDKLNQAINIDPQSGLQELMQLQELMPTVSSISLADTQGH
YLRAPEVLENDNSRAFDPKSRPWFIKQAEASTFSHYTSPYLDFFTQHPTITLYKPVISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDTGALFKPYVRDDLMD
KMTSAEGQLYDEKKGIWYYYYSFTNPDWFVIYRVDNTTLVDLTRYETDIVLWGFALAAIV
IILFGLYLRHASHTVLMNIINAIKTGDVNRAPRLEAMLSKAIESNKQRELIYVRQATIDA
LTGCKNRRAFDSDTAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQI
LQPQNISLYRYGGEEFAVIFTGEHIANAPAILESWRLNIAQRTWREEGLMVTFSAGLGEW
NMEPLEQLVVSVDEALYKAKQQGKNRIVRA
>A0A1V5HNT5|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA124|TrEMBL
MGNYWLPYLLQTNIYSIIILVIILISLRQYKESLNLGNNIFKTIIIVDIILMALDIFSCL
IEGRPGAWVTGFYYATQVISLVIAPSIGVLWFYFINVLIQKQPIPIQKKHLWFLLPFFIN
AFLAVYSLFGNSLFYIDEDNVYHRGHLFFVYILVAAFYFIISFVVMIVKRKSIRKSNFIP
LHLFLIPPLIGAVLQSLYYGLLLTWQTIALSILLVFVFVQSENVVTDYLTGLYNKREFEK
YLSTINKSRYRFRKLGGIFFDLDNFKQINDQFGHLMGDFILREIGNILRQSFRRTDFLAR
IGGDEFVAFFEISHKEDIRVFQNRLLANVSELNKTNKLPFIVSISMGIDCFDAKSPFSIH
EFFAHLDKLLYEQKEQKPIFHLHPADGESSLKQK
>A0A7W9FDK5|diguanylate cyclase|EC 2.7.7.65|Brevundimonas variabilis|TrEMBL
MTARILVVDDVEANVRLLEAKLTIEYYDVMTCQDGATAVRLAAQEQPDIILLDVMMPGMD
GFETCRQIKADTNTRHIPVVLVTALDGRDDKIRGLDAGADDFLTKPLDDVVLFARVRSLT
RLKLVMDELREREESGRRLGVNADGAGRLRGSGGRVLIVDDNLRQAQRIADELTREHRPV
IETDPKAALLASRGLIDLMIVNVAAESFDGLRLVAQARSAETSRHMPILAVVEPTDRPRL
IKALELGVNDILMSPVDPEELAARARTQIRRKRYTDFLREKLDYSLEMAVTDALTGLHNR
RYMTGQLQALVQRANHGGDPVAVLVMDIDHFKAVNDGFGHDAGDEVLQEFAVRLATNVRA
VDLPCRFGGEEFVVVMPDTRIEDAHRIADRIRRDVSSVPFRVMGGKETLNITISVGVAVS
LGQGDTPEALLKRADEGVYEAKATGRNRVIARAA
>H6RRV4|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MIDPDRRAPDLGIGAPEPAVADRVEREVAALTLAVLLVVGALMGSINLFVDGVLRAGAGR
WAYGGTMLLLLSIAVSLAVRGRVGGGHTFALVLIGDLIYLVVVLCIEDPLRYATPLMLLF
PALVAAWFLGLRQLCVHMVATAVVCLAALWPSYDSAVGLGVQVGVNAGTLNAAAVGVFLL
RRRVQRLLVATETLSRLDPLTGLFNRRYLVEQAPRLWGQARRDATQVSAMVLDLDHFKRL
NDEFGHAVGDSVLGAVARSLSATVRPADVLARTGGEELVVLGAVTDLTEAIHLAERLRAA
VAESHGAEEHAVTASVGLAVARPVDGEDPVAALWRLVDRADVAMYEAKRTGRDRVCTSAR
SPEPEQTTVC
>A0A7L6XJZ4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C05|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRKLASEIAIHHAHTLSIEFYRIVLADPHAEEFLSNEQ
VERQLKHALEKWIVDVLSCTSGDVDELIKVQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PIIIDSHHEATEKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQIASLLAWEMDIIYKIMLDADFGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGLFHQTRGTAKALNNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPDGEAIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRHGRNRVELWKPGA
>A0A485BLD0|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLINSRPLLNKVLLYLLICIIATGLIHLFASSLISRTSTASPVLLPVLTIFLLILHLTIS
CFMIMKYWCVRERLYLTAIACAFAGSALLMLGTLSGHTGWFLCSQGPMPNANDALIFFTF
RNAMMVILFTIAIVLYRFRHSPRLTKRVHALILTGCLSFTILIITLSWLYSSNHPLLNIA
LVDNLSHQFSPLWHNFIGRILVASWLITLTLLIYISRLKNIFWYSGAFFCSAYIFTLLVL
MPQSDMLYSWYHARTFEAISTLFMLFVLLCDVFTLYRHSNNKYLTSYQNSIRDPLTRLHN
RSYFYDALNAQLTKASASQPLSVIVSDLDYFKRINDSYGHVQGDKVIQFTADVLQKNVRP
QDVAARIGGEEFALLLVNTGPGDASAIAERIRLAVNERQDALPERMTISAGVFTAVDGSL
SAEECVKRADTAMYEAKSGGRNRVVVWSEVK
>A0A3P8M3I2|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLLIDPHRDGRIIDANIAALRFYNYTADEMRAKHTWQINTLGRDVLPIMRNVASLPGGHK
PLNFTHILADGSIRHVQTYAGPVVLYNIRLMLCIVHDVTEEVHLRRELEFSASHDPLTGL
LNRREFYRIVDSASFKPTGFCLLLVDVDNFKAINDSYGHQKGDEVLLTISRILESTVTHQ
DKIYRWGGEEFLLFLPERSIEMALQMAESIRLAVSGYQLADHPVR
>A0A4U9DBP4|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MDEIFVQPRWMGYYCEDLLRLSGMLLTTIGIYKIIDRINILYVDARSQSLKDELTQLPNR
RFFIDTIREKQGHQLALMILDIDFFKKINDTYGHLMGDEVLFALGKQLAKLTSDKIQPAR
IGGEEFAIIVDGMSPEEVRSLAQSILENVRTILINSDYPLSVSIGVGMRGRDEPQEAFIK
KVDEALYKAKNSGRGRVEWAAA
>A0A399ER20|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MPGGFASWQEVRQSLLLRVALGISLLVIYAAEPFGFNHALMWGVFAVIAVQVVITALGIP
RRWPGLPGFNFYVNRLTIVLLLGASGGGSSPFVAVSYMSLVAALIWYNSPRDVLVLVGSH
WLALFAGAALAGAAGAAPTWSYCLLHAIGLAVIAYTLSKPLSQLNRHAATDPLTKALNRR
GGLEVLETWVAQRQPFALVFIDLKQFKAINDTYGHSVGDEVLVWVVEVCRSNQRSGDLVI
RYGGDEFVLAVIGKPGPLVQRLERRLDAGLQTTAGHVSVRANLGVANFPKDGHHLEQLLH
LADRHMYAHKGAVTA
>A0A7C9QS88|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum aberrantis SpK|TrEMBL
MKAEDAFASLTGFQHALAGHVEWLQKWYQAVLHRSSGTVLPPADGEHCAFSLWHTQAAGG
PLAEFSGFAALGEEHAAVHAKAEQISARAAAGQTITTSDYETLMGSVLSFGNAAQALERE
VWKALATVDPLTGLANRQTMRTQLTGERDRAIRQRLPLSLALTDIDHFKKVNDTFGHAEG
DSVLRAVAGVLRGAVRPYDVVYRYGGEEFLICLPGTNAENGAIVLDRIRQAIEALRLTSE
KGEPIPVTATFGLAEVDADTSVDDAIERADKALYDGKRTGRNRVVTYSE
>A0A4R0GLU8|diguanylate cyclase|EC 2.7.7.65|Kosakonia quasisacchari|TrEMBL
MENYLKLMKNEWFHLIDKTDERIRFLAAEVGKTHAHILSQEFYRIVLTDPHAEEFLSNDQ
VERHLKRALEKWITDVLACQVSDIDRLIAIQQHVASIHARIGISVEIVEMGFRVLKKILF
PVINSSSYAAADKLEVYHYAINSIDLAMEVMSRAFTFTEHNSSKEDENYRIFSLLENAEE
EKERQIAAMLSWEIDLIYKIIMDADLGNSLTLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LIQDLDEVFRNTRNTPRALSNRTLRVKFLIQIRNTVSQIITMLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHAKRMNTPLSVLIIDVDKFKQINDTWGHHTGDEILRKVSSAF
YDNVRSSDYVFRYGGDEFVIILTEASEFDTLRIAERIRSRVEKTNVISPSGENIALSLSI
GAAMFSGHPDYERLIQVADEALYIAKNKGRNRVELWKAPD
>A0A1A8XSZ1|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MRTVPIFGPSLLAILTGLLVTAFVGYSLVRERDVALEVASLETENFARVLEEHTRQSLRR
INTGIVEANAALLESRDAGIRDPAKIAERLRGLLPPDRIIRSFLVLDRTGMIVLSTQAIE
AGRAGSRSDRDYFIPHVRGADRELVFGAPEPGSGDNKWILPISRRISTADGEFAGVLVAM
VHGAHFQPFYDSIDSRPDGFVTLFLSTGWAAVSSPSDPTVVGRNWSDTPLFRMHIPNWPT
GTVREVLFGAGIERIYSYRALNDYPVVVSYGLAIPTILGPWLQIAWRDGFLLLVVLAALS
GIATMLIRHERRRRKTESDLRIAATAFEAQQGVIVTDADTVILRVNRAFTEDTGYSAEDA
VGKTPSMLSSGRQDQRFYADMWHTLNTTGSWYGELWNRRKNGQEYPERLSITAVNDSAGR
LTHYVATLVDITHEKAAALEIEQLAFFDPLTRLPNRRLLMDRLRHALASSARHGLHGALL
FLDLDHFKTLNDTQGHDVGDALLAQVAQRLVQVLREGDTVARLGGDEFVVLLEGLGERSL
EAAELVHVVCEKILTTLNEPYMLNACQHHSSASIGATLFSGQQKTIDELMKQSDLAMYAA
KTAGRNTVRFFDPNMQATITAHALLEDDLRRALSERQFRLHFQKQVTHDGRVVGAEVLIR
WLHPGRGLIPPVEFIPHAEESGLIEPIGQWVLETACEQLKRWEGNLRFASLRLAVNVSAR
QFHQSDFVQQVRDVLKRTGAQPNLLKLELTESAVLTNVEETINKMNLLKTDGVQFSMDDF
GTGQSSLSYLTRLPLDQLKIDQSFVRNIGIRREDALIAQTIIGMANNLGIEVIAEGVETE
SQRAFLEQHDCPLCQGYLFGHPMPIEEFERLF
>A0A8D9L3X2|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MNSRKNHNKKLMLPVLIFLVGCLVLTVVLYHSYRSNYKQVRNVTALNATTYAERLQNDMN
RGVAITDTLEEIAISENGKIDNFQKVARDLMADFIQSIQIAPDGVVTDIYPEAGNEAGKI
DLMHDESRGEICRYGRDKNIVTMQGPFDLKQGGQGIAIRNPVYLEGADGSPVFWGFTIVI
IRVPEIFTESIQALTKFGYDYSLTKTVSPLSDDTEIVSSSGNIMKNPITFEFEFCGSLFD
FEIMPADGWSHGWNVFPQLFLGICVILLLTGLTVVILVIERHRDTLKKMAITDPLTGLLN
RKGFDEQLKKVMQGDLHIHCVGIQMDIDDFKFINDMYGHVVGDAALKSLAQDIQSYFNDN
SIICRNGGDEFSAILVDTTEEEARKKIEQFTLQSRHITYNGGEHPFYISLGYAEYPKDCE
DVSELIRCADMALYAVKLHGKHNCSPYRGAYKMQHRSQLGFALQDVSKNLPGAFLIYIAD
PENDNILFANRELIEFAGCRDFDDFLDYTDHRFRNLVHPDERDSVETSIWKQIDAKTSGN
NDYVRFHFAKKDGTYLPVLDHGRIVENRYYGNVFYVLIMDCALVESYYDNKTGLETVPE
>A0A7Z9BEQ4|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MLTPHNSRFLAKNRVFRVDDQSSFVKQTEAELQQQKLDFQVVNRALAVLSACTQAVIRAT
DEITLLQTLCELITQEAAYRMAWVAYVCHDQVKSVKAMAWAGYEADYLETLNITWADTER
GRGPTGQVIRSGHPVACQNMLNDPNFAPWREAAQQRGYQSSLVLPMFNNGEVFGTLNIYS
AEAYAFNPKEVELLTQLTDSLSFGIIALRAEQSLRESEQRYRLLAENISDLVCLHDRDRR
YLYLSPSCESLLGYGYDELIGKDPYILFHPDDRDRISEEFRAAILGKNNISITYRISQKS
GNYIWLETLTKPILNEAGKVVQIQTTSRDITERILVRERFKYEALHDTLTGLPNRNLLME
RLKLGINRIHNFEGYHFALLFLDLDRFKVINDSLGHLVGDQLLIAVAHKFQSILRSTDLV
TRMGGDEFVILLDEIKDIQEAIRAIENIFQALACPLIVEEREIHISTSIGIVFGTKDYIR
AEDLLRDADIAMYRAKKKGKARYEIFDREMHAIAINRLHLENDLRGAIKKQQFLVYYQPI
IDIFNHRLIGFEALVRWQHPTRGFISPAEFIPLAEETNLIVAIDSWMLSTACQQLATWNK
KFPSCQPLKMSINLSAQDFRKVNLIEEIDTILRETGLEGNTITLEITESMLIEDINKTID
LLTKIKSRNIQISIDDFGTGYSSLNYLHRFPIDNLKIDYSFVSQMQEKNRNYQVVSSIID
LGHHLDLVIVAEGIETAQQMQWLRAMGCELGQGYLFSKPLSPQEIEIKFLK
>A0A7Z9DVN7|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MLYQKNLFGLATIMRPLLNWSCRLLGLPSLNELEANLLAETIKIEQMKQQQNALYRVISK
IRASLDIDYIFRTTTKETCKLLGVERIAVYRFYEDWGGEFVSDFEFAEAGWIDQESLGKN
TVWIDTYLQQNQGGRYRDNQTLVVSDVLKTELSQCHLDVLQQFGIQAYATAPIFTKQKLW
GVLAAYQHSKPRQWQNSEVEFLAQVATQLGFAVQQAELLAQSEQKAKDLQETSEQQQILL
TVIAAIRESLDLDILFKTTAREVLKALNADRVGIFRFDPETNYCSGQFVSESVLPIYDSA
LIIPVNDRCFGEKYALDYQQGRMQVLNNIYESGLKDCHLKILEKFQIQAHIVSPLMKGEI
LWGLLCIHQCDRPRQWTQTELQFVKQLAAQFSIALRHSDLLVQTRSQAEQLNLTLKELKT
ANLKLENLARRDGLTGIANRRYFDAFLHKTWTIARNNHQYLSLILFDVDYFKLYNDFYGH
PAGDQCLINIARSVQKILRSTDLLARYGGEEFAVILPNTSPDQAYRVADNIQAVVRNLTI
SHVNLPTGKSIVTVSQGISSQIPRADQIPQDLITESDQALYSAKKQGRDQWVSWVQPLSV
IS
>A0A1V5Q8P7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MEGSNTTIVISELGKRNMNEGGLKVSPRLYICCAHDIVRVDLKGKQRLGRPSGNDAPDIP
IMNQHVSKDHGVFLTTEEGCEYIAGNSANGIYYNNRLLSPNARVALNDGDELRIPTADKI
DILIVFVNTNGRADLWEAFRKASRDQLTGLNGRNGFINWWSDHREKPEYGSAALFIMDVD
NFKQINDGFGHTKGNEVLRFVAGQLVKAAGFPERVCRWGGDEFIGIIPGDAETVGKILKK
LCREIAGSSVIDTKLSVSIGCVDLSGIKDRLDLSNLVSIADSALYETKRHGKNGVEWAE
>A0A1C7FFV8|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MRFCLILVSFLFSTFFSTLVSAKDKDVLIIHSYHQGFFWTDAFQQGLEEVFKHSQISTRV
MYLDTKRLQSASYLDQLYRLYKTKFSEEKFKAIVVSDNTALQLMQRLAPELGDTPVIFGG
INNYDPSMHQGLKATGITEDIDLLSNISLIERLQPEVKKIYVVTDYSITGDAVRQQLDKF
MAMYPDYSAVIEPLAPKTYGDLLAFVQTLDRQSSVLFWVYYRDNNGWITGKKDWQQLNQV
TGAPIYMVHDLDMGFGAVGGVIQSGHIQGQQTAGQLMKVLAEPNASLPVVQIGSPEIKLD
YQAVIKWQLGVDTESPSVFFNKPLSFVERYEEQLRFVVSLFITLAVVIAVLLYYLSRLKR
SEQMALDNQTLIEMVFDQSYHYIGILDQNGCIVSSNSKLQDLLYQQNSVSEKPIWFHHHW
EQNAADRIERYFLTSDESSNCQFEAEIWHPEQGSMVLELSLKPLPLHEHREAQILLEARD
ITSRKLTEERLFEREASLSHYYDQQPVMMITLDEQNRIQQVNRFAEQLLGYKENQILGHR
LKSFYVDDDASIPRQVLLQPKQVMKGVWRREVEYRHQNGHSLWIRENIRPLVESGHLLIV
GEDVTTLRQMADQLAYQAQHDLLTDTYNRNHFEIELEKALKEVESYTRTHAMLYLDMDQL
KVLNDTAGHEAGDAAIQFCASLLEEVLPYKAILARMGGDEFAVLLKDCTERDAKNVASSI
IAMLAEQAFIWDDIKLNLACSIGIRLIDHTATSPQMVHAQADTACHAAKEEGRNRFSLYC
QDDQDLRRREMEMACVNMVHNALNNDRLELFAQRILGLEQDDHRMHFEILVRIRNADGEY
ISPGIFMPASERYNIAHLIDKQVVRQTLQWLAQHPNAMDNLAVCAINLSGHSMGNQEFID
FLLNELQESAVPCNKICLEITETAAMSNMNQAIEFFAQLKQLGCLIALDDFGSGLSSFGY
LKKLPVDIVKIDGLFVRDIDNNEMDHLMVRSINDLAKQMGKRTVAEFVENNQIIDLLIEL
GVDYAQGYAIGKPKPLAELVEELSEELDNESETFTTQA
>K8AD31|diguanylate cyclase|EC 2.7.7.65|Cronobacter condimenti 1330|TrEMBL
MPDKILISRWRTKHPIRVVNLCFCAVFIFSTLLTWREGVILQEAFISSQRNQLDTIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLAGPETDNAIAAFQANRAKSAWSLPTERDLALPIK
GVSDKFIAQSTLLERDEARLPNELNATLALGHMLSIADSRGERPEMRTFYVSRAGFYLTS
LPFFGNESVPEQYYQQVSSRWFLSQSLRNNPARGVRWLHGADLSMPSGQRVTASIPLDDE
GRWFGVLAMDFPIRAMRDFLKNALSNDDAGGEILLFDRQLSLIATTSSGIDPALRFSAQD
KAILSRQMERGNAGDARMDTRFIAWAKLDYFDGVLVKVTTFSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLFNRGAFFERARLAAKACNEQ
QQPFSVIQLDLDHFKSINDRFGHQAGDKVLTWAAGMLSRTLRSDDVAGRVGGEEFCIILP
GTASEDARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEAQRDGDYDFEHLQSIADHR
LYLAKQGGRNQVCHEG
>A0A1T4RR13|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MFKLPLLLKKHKKKIHKLDNIKMFFIVAILLCILCGLCICIISFSNIKILNENNLFYKYL
FDTLNLLFILIAFILLQCTNFLVKEAHVILSVGLFLWGGALFFIVYNDINIQPIWISLWM
SNIFRTIGISLLIIGAIIAIKKSNRKCNYFKVLATIDDLTELPNRRYFYEESNKHEDKMI
LFIMIDIDNFKKINDKYGHDEGDRILHSFGKVLLNYKNDNIFSARLGGDEFAAFIISSNK
QEAVIFAEYLLEEIKKIIVREGNHITLSIGMTYKLPCELNRSGLQRADKALYKAKNNNRN
RFEWE
>A0A5I3I7K9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Nima|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F5EZA6|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MPAPPRLQAAHARRPWSWLALASAVVALVLALDAWQEYRDTGQRERRQLTQQAATLHDNL
ALQLDAAGHALSSLLAELPSLQRESDGKAQLSVRLRAYADAMPAVQYLSLLDAQGTITVS
SDPALVGRNSGQRDYFAAARSASPLTLVVSPPFRGALGGWVMVLARPVFAPDGRFAGALV
AALDADYLRLLMRPLHGGPDVLVSLSHGDGLRFLALGRSGERDGVKLDVAGSAWSRHLAS
GAPDSLLTAPMRPEAPQEQQIVALRTLQPPELHMDKPLVIAVGRDVPAVYADWRSDVASA
LLLWLVGNLLAAAALLWVQRKQRQRQREQDEQAAREAQNQAHWDVVLAATHQGLWDFDKA
AGTTSYSPQWYALLGYTQEAFEREGKTWEDLVHPDDRPKLATAWQQVLQGQKDELEASHR
LRCADGSYRWFACQGRVMERDAGGAPLRVFGTLADISERRQQEEMLQRLTENLPGLLYQY
QLEPDGHSHFPYTSPQVADIYGFSAQELQQDAAPVFERIRSGNVPRGVEDLRRSARELSE
WSAEYLYEIPGRGARWLSGHARPQRLPSGATLWHGYISDVTEAKEQSLRLQATERVLQQL
MSEMPVGLCMVDARHRVYFRNQRFLDQLGYDEHEVPTLREWALKAYPDPDYRAEAAARWK
QAKAEAVNGQIAAQSYRIVSSDGAHHMMDVAGLIFGDKLLLTFQDHTAHLVQNEWLRKLA
YVDGLTGIANRRSFDEALAAEWSRCARAGLPLSVLMIDIDHFKAYNDLYGHQKGDACLQT
VARTLSQSMARPHDLLARYGGEEFVCLLPQCDLEGARVVAERLCGAVFGQALVHEGSSAA
PCVTISVGVACTIPELQREPATLTELADVHLYRAKLTGRNRLSDGLNDSWNES
>A0A4R6EBF4|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. JUb87|TrEMBL
MSTSRANRFRLPLANTLRVIHLCFIFVFVLTAILFWQQGQLFSQGYRTGQLSHLESVIAR
LESRAQYKVDNLRYLKRIFIEAMDDPIFPGSPVAPWEVNENAIQRPLWIGELPLPDTVTE
DEAFQGKESQEVRNQLNGLRKIQGLFPLATGEHELLADLYYISREGEFIASLSQEVNEQL
INSYNPHEKQGSFVLASPLLNPRRAPFWTRQNIANSDETVINAAIPVDFGGEWVGLLGIA
FDNQSVQKFLASSLPEGTQSAYRLYDEQLKPLTKAVGAENNVQLNVEQKKTILKMLIDKP
RGTFRSGSVFITFGKLRGTHSVLVSTQTLSQGLHEDFGRFSLLLVTMFLIFVLSLLGAHR
IICRLVGNMGNLQREMQHHALHDDLTGVLNRRGFFEKTSQVSPNYVDYTLVLLDLDHFKK
VNDMYGHQVGDNVLIHATGRIQRAIRKQDILGRIGGEEFCIYLPNSDLKTGIKVATRIKW
ELESSALILEDGSQLPVTASLGVASYREHPEYMLEQIQSLADMRMYRAKARGRNQVCWLG
EDKFQA
>H8FWJ7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MRPLDALFGQAAFGEGEEYRKFQYRFTLAILMFSAVVTAIFHLSVHHGLAQSDPTYLNVS
RAFLAISVVFYIVLRGHPARLGLVAWTYAVLALGLHLTTFHLNSPDELRIVWVILNLAGV
YLVLGPKAGIAVTVISVVAIVATNPLLPHPYSPSAVVTFVMAMIYLSAFFHSFTAKSISF
HHAMVEANRRLAEMADHDPLTGLYNARAYYRLCDATRHQAQRTGSPVAMLFVDLDHFKKI
NDQHGHEAGDAVLRATAQCLRTSLRQSDLVGRIGGEEFSITLPDTPLDAARRLAEKLRED
IEALMPDIGATRLKITASIGVAADRKFAASVADLQRQADEAMYVAKRQGRNRVTYIDDIP
VTDPA
>A0A1Y6IZ84|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MRDILFRKWTVIGFLVLLACILVVLVEFIFQRHQEVMRQEIQSRTTEELSIIRFKLEATV
LADIYVAKSLSTLTTVNASTVAESWEKVSQRIMDQGKYIRSLALAPNDIIEYVYPLEGNR
KALGLDFRTIPEQWATVQRAHELKEIFIAGPVDLVQGGSAIVARCPVFLDPPYNQFYWGV
ISVVIDIDSLFKSLAVDDVLRGYNIAIRGKDSAGEQGDVFWGQPDVFEHAFAKETIYFPY
GSWSIAIAERDNINILDQVPWFQAHIVRVIGYLLLVFLIASFWVIYRLYDKSNRLSLYDE
LTHLPNRRYFMNELNRYFEREKKARQPTGFALLCIDVNKFKTINDNYGHIVGDQVLVECA
RRIENAIRDNDCAARIGGDEFLVLLKGGEKEEDLRKIMERVRHAVRVTPVICEELAIPVG
ISIGYTCYRPEMKSVNEMINHADNEMYDEKYAS
>A0A0T9Q4L9|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYAAEEIIGQSFELF
YTPEDLAGKLPNKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDADNNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDNG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIAQHFGCFFLPEDIAAGLPEKLLKTAASAGRIEREGWLVRKDMTRFWAVTII
TVVHDHNGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDC
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNRLDAFNQCLNEGRHTLLPE
GSQLLSSQGERQEIRCSASPIHDRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLADSLSELSDNEQHILCYVDLDFFKDVNDTAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCKNKPATDILEQVVTDISAIQFHWHGQSYTFTASLGAVTL
NRQSETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A7C8HVQ6|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MNGQTKKLMWGLGISDEDANVIQHAAGGRFALSCFPIGVTPTVDQLETDEPCLLWISKQG
WDTLKTLPSSDTAHIDVTSRILIMGGDYDLAELESLLECGFTEIIKPPITKERARDVLLS
AVETQNLYQDIMHMTREICLEREMLERKNDMLSFIVSFLEKVTQHLDPAEILRAAQTELK
TLLPVSAINAICWSPQVSENVHATIYVAGSEKNDVARAWTEMLKTHAQRLLGDGVVSIDM
NYMGTVKTEILPSSDTLLAIDLEHGGANFGVVLVQCHEHPQLGKDQIQILRSAISHLTLG
LNNAMLYTAAQHNADIDGLTRLYNRRHFDARIVEENTRHRRYGHSLCLMIADIDNFKNIN
DTYGHLAGDDVLKDLSRILESSLRTSDYIARFGGEEFAVLLPCTSASHATMLAERIRIQI
EEHSFVTDKGILNVTASIGVACIDHTHEESPVEIIRRADAALYQAKDSGKNQMSILYPDK
SLLVAGGYAT
>A0A6C0Y3Z8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKVIVTKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFAFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSQLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSNQQQKLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A603BHV7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 50:b:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYIADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A655BNZ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MNYSHDIPGGLRVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENIS
DAMTGLYNRKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLA
KAIKTSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIY
NMQPNDTINDAYQASDAQLYLNKQQKQHRSS
>A0A736TUC4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5P9IJJ1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MSLGRRLLLVAMTLLPGPLLAEETLTLGVFAYRPEAVMEARYRPLADYLGERLPDHRVEL
EVMSLDEIEEAISHRRLDLLMTNPSHYLEIRSRNSLTGALATVINAQHGQAVSSLGGTMI
KAAGNAAIQELDDLAGRRIAMPGRRFLGGYQTHALELMDAGIDPRRDIEPMIAGSHDAVV
AAVLAGEAEAGFVRTGILEGLIAEGELAPGQLEVINPQRLASFPFAVSTRLYPEWPFVVM
PQLVPETVRRIAVALFTLEPEHPAARAAMIAGFAPPQDYLPVENLARRLRLPPFDAVPDF
TWHDIWQRYAGFLLGLAAAGALVAALLALLARRNRQLRQQRERLSLLAGVFTHSHEGVMI
TAPDGELLEVNDAFSQITGYPRGEAVGRNASLLGAGRHPQAFYADFWQQLKRTGHWDGEV
WNRRKNGEVYPQRLTISAVTDGAGEVQRYVGLLSDITQLKAHQRALTHAAQHDALTGLPN
RALLADRLRVAMAQADRSGQRLAVVFIDLDGFKAVNDTHGHDMGDRLLVALAERMQGELR
ASDTLARLGGDEFVVVLLDLASDEEGERVIDRLLAATAAPVEVAGRRLQVSASLGVAYYD
AAEGGDEDQLLRHADQAMYRAKEAGKHCYRVYEAPCQV
>A0A7H4NI53|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MRVNIKSLPYRIFIYAIACSLSIAVVNFITTSLIHRISTTSSMLFPVLTISLMGFHIMIA
CFMGMKYLCDKNQLYLAPIAFAFTCSALLMLGTIGSYPDWLVCAEGREINQNDALVFYFF
RNVMMAVLFITSIVLYRIRHITGHSRKIHGAVLSSCFIFITATLILSWVHSSNSPLLSIE
FIDNLTYTFTPLWHNRIGWLLIIIWSLTLILLIGLTRLRNIFWYSGAFFCTAYIFTLLVL
LSTVSGNAHSWNQARLFETLSTLFLILILLGDVFILYRESNERYVRSYQNSIRDPLTRLY
NRSYFYDTLTQRLSKASASQPLSVIVCDLDRFKRINDTYGHVQGDKVIQFAASVLQNNVR
LDDAAARIGGEEFAVLLVNIAANEALAIAERIRLSVSEKQEGLPERMTISMGVFTTQDAH
VSAEECVKRADTAMYEAKNSGRNRVVVWRE
>A0A2J5Q099|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVSAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A5P9ISD1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MIPFLEPFDTTETVIRAAPIGICITDAEGRFEMVNPAYCEFYGYREEELLGQPFTLVVPA
ADRARMNDLHARFIAGDSALEDTQECEVQGKDGRPRSILAKAARIHDGQGRVKKVTFVVD
ITERKAMEQRLAYLAHHDELTGLLNRRAGLDLLEEEIRRSRRYGTPLCVANCDLDHFKRV
NDRHGHAVGDRVLREAGALMQATMRRHDHVIRLGGEEFLLLLPGVPREEASQAVERLRAQ
LASTPITDERIPLTLSAGVAQLAGDEPADALLERADRALYDAKHAGRNRVQETADARPVG
EPVS
>W8TLN4|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium acidaminophilum DSM 3953|TrEMBL
MRSDSVNLKIDNIMEGIGFLSHIYDAVRLVDPVAKKVYDIGDNPVESESKCYEFWNTGQV
CKNCTSMRAIKENKTFIKIEYNGERVYMVTVVPLQVEGRIFVAELLKEASDSNLVDEFLG
KGKSEIYGMLERKNLLLVKDELTKVYNRRYINERLPYEIMSACEKGEEISIIMADIDKFK
SINDNYGHIAGDKVLEAFAGVLEGCVRKDLDWVARYGGEEFIVFLKGAGCDKAHEVAECM
RKSAEGFSLEYDGNDISFTSSFGVCTLLKNLSLEKLIAAADRNLYAAKNAGRNKVVSSEY
EGGDCN
>A0A8F8XUS8|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVAGAGIWFGAIYALVI
TLLVLFVLGSLLLWFQTGSFMASAGAESLQVLVIWGIALLVFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETDRLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEENMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAEQFLNELENEMMMNEL
>A0A162S749|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MPKWHLTGKAPGRRLKPHLIQVYTSLFLEEIAEKDKGEDYKVSLEERYNQLKKEYETYQK
LAEDTIQKQSMKIIELDKKLDMVSLIVEISEYINRCLGSSEIDYLINDIMIGILGVTYSS
VYLMENRKLKLKASNLNNADHHYIVDEFNKGRIYKLNNSILNSYSNMCKDDRIQIHSSVY
MPIYMKDRVLGLIVVEHNIYEYLSDSHVKLLTALTNQIAICLENNRLYNQIKESSQKDGL
TGLFNRTYFFYTVNKIIEDEDSSFGIVMIDIDDFKICNDTKGHQCGDAVIRKISKVIKAN
LREEDICGRYGGEEIIVYMYGVKNIIDIYNRMESIRKIIAETVTCHKNIEFKATVSMGIA
IKEEGESLEQIIRRADINLYKAKALGKNRVIY
>A0A143QC15|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MFRLLARWRRLPFDYAALPDYMLRHGLLDPYRRSIGGIVLTMVVAGGALFLSPIGPTGAA
ESALMITAMVGGAVVAVLWWVRPWPTYRQSVLFVVCADLLIFCALLSVADAPTAFTLSTA
FLVVGVYCGHFLPMTALFLHVGATVSGSAILMVIAARASDGDTALLVVQLLVLATLFVFM
PLLTQVPLFHLRDDAYRSADDPLTGVLNRRGLHQVVAGHGHMHLPADHVVGALVIDLDGF
KHVNDTLGHAGGDDVLRRVGERLRVVTDGWAVVARLGGEEFGVVAAVPASVFRNRFTAVH
EAVHWGDDPVPVTASSGLAWQSADEFRRDHSDVDNLLRRADRIMYDAKRDGGDRLDIAHC
PPDAPGDRPTTRSDSTPHRRPYDDVA
>A0A1V5DPQ5|diguanylate cyclase|EC 2.7.7.65|Smithella sp. PtaU1.Bin162|TrEMBL
MNDLEKIVAALEKNQEIAQKFFEIETSVLSILNFRDFLEKLLTEIQKKRNIPYVWISLIE
GSDIACMIQKSASSEILNGRTNFIAKGAFLALINNSIDPVLVNDNLKAFQALLPQQYKNR
LQSLAVTPLTLDGEIIGSLNSGDDSAFRYKPGMGTTLLKQLATIVSLCLSNVMAHEKLNI
LASRDPLTQLINRRVLEQILSREFERALRYKTQLAVVFLDVDDFKIINDRYGHKAGDCVL
AYIAHNLLSMTRGSDVVARFAGDEFVIVLPSTSLDKASELVYRLKSFFADRPLDFEGIPI
TVSISCGLSCMEYGVSDAGTLLKKADAMLYKAKKHKSTRRS
>A0A5Y1WI46|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A127MQZ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MTENSFAFRLKELLELNKLTLQAVATALGISRTAVHKWTRGGEIDYDNLRKLAAFLKVNW
IWLRYGEEAVRDLQALEPIELPMTDVRRRYTAEIMESEARMKLAQESARIVTWEWNLISD
EVTYSPNVEEVYGWPVSHNQDFWPHLPAEDVAAMRAMYDQAIAEGSGCECDFRIYRPDGQ
LRWIASRARVIKDSAGRSVKIVGISMDNTARMAAEEELRNSEERLRAIFELTWGALAYIG
LDGTWQRVNGSLCELLGYSAEELYGMTFQQLTHPDDLERTLQLLRSMLAGEIDRYVVEKR
CRRKDGRYVWVRARTSLQRRRQDGLPEHLISVYEDIGPARAERERLQARIAELEAQLAG
>A0A378YYN7|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MTNVLFNRRRAVPVLATGLVVLLCVLVAWGLARFAADQLVANRSARLLYEERSVASRLAH
GTVHTVNQDLILIRGIPQVLAQIEQIQAAAEEIEAHPLTALPHAKAHAALLANPTLKPVN
ELLRATQLYFGADLVWLATPDGTTIASSDADTPNPLVGENYGDREYFRIAVLGGSGQQYI
IGRKTRLPGIYFTAPVYREGRLVGVTVIKLGLRRLSHWVDSGSSFITDKNGVIVLANDPT
FTGLAVPGARVFKLAPDERRRLYQQEDFSVVPIENYDLSPSTLGFRADSDTEDGVRDARL
VRVRPDDQPYLLEVDTALDSELIIYTMTEVPTLGSLVVERRRYAVLVFAVLLSSAGALFM
LVRYLRREKLQLSDTLAKNAALEHEVKYDALTGALSRAHFLKRLRAEVVQAGAAKVPTSI
ILIDLDHFKRINDTWGHALGDTVLATFVRICHESLREDDICGRLGGEEFAIILSGANEAR
AIEAAERLREAVQNTHIAVDARTLQFTVSAGVAEWHAGDDDNAWLQRADAALYLAKSRGR
NRCACESDLRALPRGGS
>A0A168Q997|diguanylate cyclase|EC 2.7.7.65|Clostridium coskatii|TrEMBL
MKFLYKLILVLGILIALSCFVQFVVFNKFFISNTNSLLLSTNEKASKDVSMQLMENFNKI
QNLVKTVAENEEIRENQELLNKFNEIIPEVDAVTILNSKGDILRMYGNIHSPGVSNLAYR
DYFREAIHGNTYISNVFKIASGTKVVVISVPIVKDGSIDGVVVGIVKLQGTSLASMFDNK
EFGRSGYISILDSHGYVVYHPNKERIGKKSIIFDKLQGKSGSKIMKDYSGEEQFVGFSKI
PNLNWYVTVITPTADIMTSRNIVVYETFLGSVIVGILIILLGIYTIKRYSKPLDNLIFSF
NALKAGKYKKIDSHNYGEEFQEMVIVYNSTIERLEKEYNDLEEAADIDSLTGAYNRRAFN
NFLSTLNEEISNCSLGSVGVLLLDIDHFKELNDTSGHLAGDNVLKKLAEIMKSTAGDRSV
FRFGGDEFAVVIRNISDERLLSIAEAIRLKCEETLNGCTVSIGAAKFPKDTYSIDKLIDF
ADKALYISKKSRNKVTIFVK
>A0A2N7RVX6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MAASHPPLVSMRLLSIKYRLLILLTLILGAGFMATSLASYLASRKAIEHGIADQTLPLTG
DNIYSEIQKDMLRPVFISSLMAHDTFVRDWMLAGERDPAQIVRYLAEVKKKYGAITSFLV
SDKSSKYYYAEGTLKSVSPEATRDIWYYRVRAMENSDYETNVDVDMANRDSMTIFINHRV
YDYHGGFIGATGIGLTLATMSHIIDRYQARFHRNIYFVDGAGTLVLSGKSMGNGHGNIRK
LPGVNTIAGQIINQRSAPTHLSYQLGHAQILVNSRFIPELGWYLVVEQNVSDEVKSLQGV
FFLNLAISFGVTLLVLLLTLLTVNRYQRRIERIASTDALTGLLNRQSLELLFQRAMLQSR
RTAQPMSAILFDIDFFKRVNDTHGHLWGDKVIRSVAGVARATVRASDVVTRWGGEEYLVL
LNDCSLAQALEVAENLRAAVEGHDFGMPAPQVPVTISLGVAEYRLDESESAFFSRADSAL
YQAKHHGRNRVHAA
>A0A4U6LIN0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYEDLPLLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLSEAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQTLSNQHQPGEAERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDRYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELHIAASVTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVEAYQE
>A0A1B7I3M5|diguanylate cyclase|EC 2.7.7.65|Buttiauxella gaviniae ATCC 51604|TrEMBL
MAKTLRVIHLVFIFVFALTTFLFWQQGQLFSHGYRTSQLSHLESVIARIESKAQYKVDNL
RYLKRIFIEAMDDPLFPGVATVPSEITGDVGDSPLWIRELPLPDTLTEDSAFHGEDALQV
RQQLYALRKIQGLFPLATGANELTADLYYISRDGEFIVSLSQEMNSLLVSSYNPQVEQGS
FVLASPLLNPQREPFWTRQNIAKTDDTLVNAAIPVDFRGEWIGLLGIAFENDAVQKFLAA
SLPEDTQSAYQLFDERLIPLTGTVGSSNQFQLTAKHLQTIRQMLEVSSRGTMRDGSVFIT
FGRVVGTRSVLISTQTLSQGLHEDFGRFSILLIAMWGIFVLFLWGSHRVICRLVRNMGNL
QREMQHHALHDDLTGALNRRGFFEKTSQISPDYVDYTLVQLDLDHFKKVNDVYGHQVGDN
VLVHATQRIQRAVRSQDILGRIGGEEFCIFLPNSDLKAGIMVATRIKWELESSPLLLDDG
TQLQITASLGVAAYSELPECSLEQIQSLADMRMYTAKQRGRNQVCWQDDGVSQA
>A0A1I6D6D0|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. kpr-6|TrEMBL
MLSSPLNARTRWKMLWRKHVVPGRVVNLCFLIVLISSTLLTWREVVVLQDAYVASHRSVL
EKAAVAVDKQMQTGVNLLLFYRNGMQAAMHTPLSSDLLVNVQNEFDRVRRSPQWQINVEK
RRTLALRGVSDEAIAQNPLLNRDVPGLQNEMTAALELGYVMRLSAGFPLAPAQTWYASRA
GFYLTSGRFISVPGIARQYSALINAPWFIGQSQRENQARGIRWYSAPLNAADKNSGTVIA
SLPMDYAHYWHGVLAVEFTRDSIRQQLEEALKEEDTGNYQLYDDQFTLLISSTWDKVPVS
TFDDSERERLTQAMAKNTEGSLRIGTRLISWMNLKHYDGALLRIHTLREGLQDDFGTISI
VFGLLWLLFTSMLLISWFVIRRMVSNMYQLQHSLQWQAWHDALTRLNNRGALFEKAKRLC
DLCSQQQLPLSVIQIDLDHFKRVNDRYGHQAGDLVLTQAARLIARSLGEDDVAGRVGGEE
FCVLLPGKTLAEAVEVAQGIRMRIAGKEILVNHSQTIRISASLGVSSAPEETDYSFDALQ
SIADRRLYLAKRAGRNQVWSVDDEEPSPSK
>A0A554WK70|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MTTPSRRPADPVQEWAAILEATPPDVRQRVAELVQRHRAALAEAFYAEMLAHPQAHVFLD
AQVVHQRLHASMQRWLGELFAPRQHDELAAIVAHQRHVGEVHARIQLPMHLVARGARFLK
GRLLTTLLQEGADAKQAERALLYIGDLLDLALELMAESYVRDTQREARSEEAFRLHALTQ
NLQVERERQRFLLANWGQEVLFALHRGGEPLVLPTLRGSEFGLWFMHKGSNVFEGAPEVD
LVLRGMERVDGTLLPQLAASTAGDPAHHQALLLQLQSELDNLQYLVQMLFERHVELESGR
DALTRLLNRRFLAPILAREIHLAQQRRIPFALLMLDIDHFKQVNDRHGHDAGDVVLQQTA
ALLLNHVRSSDFVFRFGGEEFLVVLVDVPPAQAAAQADKLRRRIAAHRFDLPNGVTLQLT
ASIGVAAWNGHPDYQYLIQQADAALYAAKRGGRDRVCVADDGPVAQAAAPTIGA
>A0A1T5I1I6|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MSKIEHHIFKKNDSERKFNHFIFENKFVKKIVIILCNMLILAGLVTISIRNDIHETQLYV
QENLNQIKNAMNTLAFRNQRYASTVTKAINDLKNQQLQALVTIHYYPKLKEFGFNRGIYP
DNLLNGTLLGPGKPNKHIQNDTHIFALLDDLWAEQQHHSITYNYYYISHTLEYFYLSSKS
NAINFNATREFFSSPKYKDQRSESQPVTSLYNGFYYTAPYLDFFSNRMVITIKSPVYNKD
QVVGDIGVDIPVKSLLSSITLPNKLKSSLNLYLYDVNKKKRIDIFKGYNHTLLPSIQVYT
RLSNNILIHANISSTIFITFAVQILTFGLLILIALNYMNATLRKYKSQKQYYQLEAYTDQ
LTGLFNRRILDTVIKKTLEENRAIDKPISMIVFDANDFKTINDTYGHDIGDLALKHISST
IDDMTRDSDICIRLGGDEFCIILPNADLEQALLMADRLELAIFSGYFCHYHIKVAISTGC
TVIKPNENLHDALIRADKTLYKNKENKAENRKALQQQLNNYVFKSPPSFQKKE
>A0A3N6ECU1|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI91-18|TrEMBL
METESEPYVRLATLRQLHRVVAELNTARSLADTLQTVVDGIVGGLGYELACVNLVRPDGD
LVVAAFAGDPAAEALITGRVGSRASWDRRLTMGENWDGLRFIPHSEGWVLLEDDVPQWHT
DGPDPRFEDEWHPEDRLYAPMYATGGELLGVISVDRPRNGRRPGAWGREALQMYAFQAAI
AISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLRTN
DALCRLLGRPASVLRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVWVSLRNS
VVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRSRLGARLCRRPQ
SARATAIEALDAAYEGRGPVPETVGAGEHGFRPDGPHTFAGPDPFDFPGGPAGLGPPGGG
PGEAGPYDHHVHAVAPATDVDDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRL
TTGVRDGDTVARLGGDEFVVLADGLGAADAADLAVRLRNAIIPPIRVDGRPVRVGASFGI
GWASCGMSADEVLRSADQRMYIEKRSRSKAHRRAG
>A0A259UTW6|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MLWLQTSQRGDNVRVFYKYAPFIFAIFGIAVGLTGYYLDIFLQMSLNSLLWAGIALLLSL
AGFVTGGLIRRLDSSSHTDSLTGLWNRRYFYLRLTEEKSRANRKKTPLCVAMIDIDNFKL
INDKYGHFAGDLVLAELAAVFKHTVQATDVVVRWGGDEFAIIFPGASLREAYAVMERIRH
KVAVRFSSTYGIAISAGVISLESDQAVQDLLLTADRALYKAKAQKNLVIAAADGSC
>A0A554WMR5|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MIQHRTHVFADLDGLQAELSSEAFTRLAESSTALLVQIYSAETDRAHMRPIVSLIADRLP
RATVVGASTVGEIAHGRLLTHHTVIGFTFFASSELTVVAMACHGGDERAVGAEMGRRIRQ
WRADAAGVLLLATPLSIDAAALLEGMESAAIGCRVFGGGAGDYAAMARSLVFAGSEFFDQ
GAVAVVFAGGGLSIEPRTYLGWRPLSRPMRITRVDGMRVQTIDERPAFEVYQRYLNIAND
DQFFLNALEFPLLLERDGELLARVPIAADESGALQFVADVRAGEVVRLGYGDLDLIVQDA
KALHRSMTRFSPQAVFLYTCGCRRFLMQEDVELETLPFETLAPTFGFYTYGEFFGAARLT
LLNSTMVAVGLREGPPARQASAQPSQTEPAPPALRDPYANKHARIIARLLRFIGTVTAEL
EASNREITKLSITDRLTQLVNRIRLDQMLDEQVELARRYGTPFAVILVDVDHFKQVNDLH
GHLVGDEVLIRIAHALRDHTRKVDVVGRWGGEEFLVIAPNAGVEEAARLADKLRAAIERL
VMPGVGHRTCSFGGAAYERGDDPTTLVSRADAALYAAKAAGRNRVEIGTRGA
>A0A5K1IJQ9|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSVITYLQRLANGFSTAELDVAALPTELRAIGEQLQKTHAILQQERQLLEC
NAYIDPLTNLGNRGGLDRHVEQLWRTGDPFTCAYIDIDHLKHCNDKFGHAEGNRYILNIC
RALTETMEHNEMLFRIGGDEFVLVSPTTGEAELEQRLERVRADLIEATSDDKAPMISSFS
FGCSRVDPLAGDTRRQMTMDADRKMYRYKLMHRVQQPKDSDAPQHPIAEQFPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSVDMWLARVHPEDRDNVRSEL
DMVVNGTWHFHYMQYRVMDATGAYALCDCTGYRLDGTDTEPNMYVGIIINRSLADTIDSV
TGLGDIHALINAIGEMRRVARKAGFIAIKVDDIAEVNARFGFDAGDRVLAESAACLMDCS
RGKGRLFRSMGPTFVALFDELGPEAIDELASEIERFLGSPVLIGSLEYQPPIRVATLHLD
GVDRQPVSILNELKARLKEAPQVPGTKLD
>A0A174AQX0|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCMIVLIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYIFFDMIWTLSDGA
DGTLGIAANWISNAVSFSLFAIACLIWFIYSETMQGSHLVTSRYRVVLVTLPTALVVVLA
FTSYWTHALFYIDSQGVYRRGFAYMIQPIVSYCYVIHTSLHAFVQSRRVESLQTKAIYRT
LAFFAIPALVGGTFQIVYSVPGLCVGIMISMLLLYIICQEQLISTDPLTGLNNRNRFETY
MLALFSNVDQAEDVYLLMMDADGFKQINDQYGHVEGDHALQVVSAVLKDVCSPSGGFIAR
YGGDEFVVLQKGVTEHDIIRLCSAINNELSRAETPYSLRMSIGYARYGDGINTWQELLRA
ADAELYRIKDAKKKSGIKVR
>A0A174F035|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCMIILIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYIFFDMIWTLSDGV
STPVGITANWISNAVSFSLFAIACLIWFFYSETMQGSRLLTTPYRVVLLTLPTALVVVLA
FTSYWTHAMFYIDARGVYRRGALYMIQPIVSYCYVIYTSLHAFIQARKVESLQKKAIYRT
LAFFAVPALVGGTFQIVYSVPGLCVGIMISMLLLYIICQEQLISTDPLTGLNNRNRFETY
MLSLFSNVDQAEDVYLLMMDADGFKQINDRYGHVEGDHALQVISAALKEVCSASGGFIAR
YGGDEFVVLQKAAAEQDIIRLCAAINDELARAEVPYLLRMSIGYARVGDGVDTWQDLLRA
ADAELYRVKAEKKKAGVQIR
>A0A5E7ZDJ0|diguanylate cyclase|EC 2.7.7.65|Hoeflea sp. EC-HK425|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAADGMTALSICDQTPVDLILLDIMMPGID
GFEVCERLKTNPRTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLMTRVKSLI
RFKALSDELRLRAETARGIGLETLLAPHQGQLEEPGMVLLVESRANTQDRMSRALAGIAD
ITAIGDPQAALFEAADKPYELVIVSSSLEDYDPLRLCSQLRSLERTRFIPMLVVAEQGEE
DLVIRALELGVNDYLLRPLDPNELVARSVTQIRRKRYSDRLRASLSESVEFAVTDALTGL
NNRRYLDTHLATLVDRSNRRGRPLSVLITDIDHFKSINDTHGHEGGDDVLREFSKRIRGA
VRGADLACRYGGEEFVVVMPDTTSEIAAQVAERLRDAVAGAPFRISASGAAAAVTTSVGI
ATLEVDGEGADSLLRRADKALYQAKNNGRNQVVGQAA
>A0A380SXS9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MSMHAARPKMLGFVSEEVSAWLVAGVAFVAGSLLTALLALATHDLYRQQLRQRFELLASE
RYSRIEERFEDQVQRLDGLRRFFVFSSSVTLAEFNGYAQPLLYRTQAYAWAPRVAGETRA
AFEQSAAQLLGKPFAIYELDDAGTLQVATQRALYYPVFYTQALSRQAQPLGLDMLSQPLR
QAALDRARQPGSMAVSAPLNLTNVDPAYARGVLMVAPVFAPGNAATSPDGYVLAVISLQQ
LMAEGLPSPSQDNLMVRILDLSGQGQHEVLFQSGNEGADTDLAASHLLRLADHDYQLDIQ
PSLAFMDANRSSAVNAVVLLGGLLSLLLSALLFSLFGQRQRALTLVEQRTAELRVSEQSL
RDTHSQLRSVLDAATQVAIIATSLRGVISTFNAGAERMLGYHSAEVIGQLTLEDLISPQE
LQTRARALSQRYGREVSPAQAMFAETVQEGESEPGEWTLLRKDGSHLLANMLVTAVLDEH
GLWVGHLAICIDVTERKRVHEALAARDRLLEKLSAEVPGGIYQFRLDPDGSSCFSYASEG
LRDIYEIDPQRLREDATAVFERIHPDDLAQLRASIRYSADHLTPWREEYRVLLPVAGMRW
IRGEATPEPADQGGTLWHGYLTDISDLKRVEEELRALSVTDALTGIHNRRYFQERLKAEL
ERAQRDNQDLAVIMLDIDHFKRINDLYGHAVGDHVLRSLCQRINHRLRRTDVFCRLGGEE
FMVLCPGSNAGQAYTLAMELWQGLRSVAVDGVGVVTASFGVAGWRPGEGADALLLRADSG
VYAAKQAGRDRVESELP
>A0A6N2RK61|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKSLKYKIVLAIVIIVCIMDVSFIFVNYVNYMNVNRNYTDSLAQTVANTCRLVVDGDSV
TGYLDNRRRNTAYYEVWNKLIDYRNTSENVLQISVVNFRDGGGCYVYDTDLTENGAFLGD
IRPYDEVQNAIKDELIACEKIEPLEYNGRSDYYIPLNSSYNIPVAYIIVGISTENVRREQ
LTYLGYITIIVTSITVLFGVFMIWFMQHNVLGPLNAMSKAASSYSIAILRDGKESPISRM
NIRTGDELERLCESMKKMEHDIIASSSQLAIADWNSNHDSMTQLYNKRHYKEQLKELQND
CTIGVIYFDIDNLKRMNDTFGHEKGDAVILKAAEFIRRYLTEQASGFRIGGDEFVMLIRD
CTEEKVQELVSTMRGDEKGNLSDVTAEFYCRLAIGGAFRKTAETLEETIKRADDEMYKNK
HSVRKA
>A0A1D8AR56|diguanylate cyclase|EC 2.7.7.65|Lacunisphaera limnophila|TrEMBL
MTFSTRQKLFFSHFLAVVLVSGSIGSYFYQSAIDTLLGSLQARLQYSTGLLSRTFSPTEL
DQLLTVADKDNPAYREGITRLRELVGSNPDIAYIYVLRRTGDKVQFVLDSDPDDPAQPGE
IYQVSAPALRNGFTTSSCDRELIHDKWGTFMSGYGPIADSNGRYAIGIDMRADEVENKLY
ELRRTGILSLALSILLALLFAQMLSRNFLKRIYALHRRCVAMAQGDELSPIGSGDELSQL
TATFDDMLGRIQRHHSELEQRVARRTAELQTSNQRLQGEIAERERMAQLLEHNARTDFLT
QLINRRAMAQLVQNDLERIGQAGGACALVLVDIDHFKRINDQFGHDIGDDVLKAVARALQ
AAVREQDVVARWGGEEFLVLLPNTGEAEAVEQAERLRQLLDNAQFRIDRYPNRVTASFGV
SEYHHGQTLELLFKQADLALYQAKAQGRNRVYAQSGGAA
>A0A1C5L939|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIDVNKFKRINDEYGHLVGDQALQTTATVLKNYFIQNHPFSDLYRYGGDEFLIIHHSLDE
QELKKIKQELTQEFQKLDMPYSLTVSIGYSCGNVYSEETIKKVYQEADKNMYKQKN
>A0A1C5WSI6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKQKTLIPLIVFLLGICLVGIILYKVDSHETAQNHTTALLNATTYGERIKNEITEGIDVT
DVLKQILISESGEFNQFDMIAENLMSDSIESVQLAPNGVVTDIYPSTGNEAGKIDLLHDK
DRGKISCYARDNHTIITQGPFKLKQGGSGIAVRNPIFLKDENGLEYFWGFTIVVLRVPDI
FSDAVSALSSFGYEYRISKTDAPWSDTYNIVSQSNDSLINPVSYTFTIGEEEWMFEVAPQ
GGWRNNLLIAKTSVILIANVILLSVLTCVWLTSKENKNRFQILAHTDSLTNIYNRYGFDE
LAAKMIAKNPKTHFVAALFDIDDFKFINDIYGHGYGDKALKCLADNMKAFFPSDAILGRN
GGDEFCVLLPNYTFEEADAQLQQFTSLPKTFSCRGREQQFYISLGYAEYPTFASSLSQLM
RCADAALYEIKLHGKNGCMSYKQELQFVVRKQLGFALRDISEHLPGAFIIYRADKEDDEL
FYANHEFLSMTGYKSMDEFFRLTNKSFHNLIREDEQQQIEASIWEQIDSGNENDYIHFHL
RKADGSYLSVLDHGRIVESPQYGKVFYVLFMDWEDMHIHYSDKFSG
>A0A853P2N9|diguanylate cyclase|EC 2.7.7.65|[Arcobacter] porcinus|TrEMBL
MDKVSKMIFTKGISLKNTIFLFSLCIIIILLVVMGSQLLFYNKELALSKVASKLKSITID
LKNNIEQKDITYSSTVKVLSFLENDANVLEIYSKLLKSNPSVYAIYTLSKDNKFIQVINL
DIHKDLGNYFKAKQNDKWLKLEDVNNSLNSIQFTFYDENLNETSKRTSFNDYSAEKRPWY
ENALKNDEVSKTYPYEFLNAKAIGITYSKKSYDNKSIVSLDLLVHNYLDTLKTHIDLNSM
ELFLLEPSKRVLSYLSKDPKIFQEILNNDLVLDDYKRAKVIENNGKKYILRIINLDNYNN
GYLALLGDYNKITEPYNKEALWLLSVFLFVNILTIPIILYLSRMIVRPIYSLVEQSNKIK
GKDFNIVHIDSNINEINLLSNSFTSMSKSIYEHQTSLEEKILQRTEELHLKNIELEKLSI
TDKLTSLYNRVKLDTALKQEFDRAKRYNEVFSLILIDLDFFKSVNDTYGHQIGDDVLRES
AQVFKSCIRETDILGRWGGEEFLIICPNSSSENAMVIAEKLNESIKKYNFTTYPKPITIS
LGISSFNHNISKAEDLLSFADIALYEAKKKGRDKAIIYNSIK
>A0A1C6ALW1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTMDEARALVTQLNLVFDIVRFVDVRMMQEYTFAEDGQFIGHPYHCYNVWKKKRRCENCI
SAKAFIHRGRMTKFEFIDNEVYHVIAMYTEIDKIAYVLEMVTLITDEALFSAYGNNEFVE
TINRYNRKLYTDPLTGVYNRRYYEEQLSGLSKEFSIAMLDVDDFKNINDTYGHKAGDDSL
CNIVTTISSLLVEDDSLIRYGGDEFLILFQHMNKTGFIQKLESIRKAVENIRLQDYPSIK
LSVSIGGISAIQEAMDAIEAADIQLYKAKHRKNCVQVD
>A0A1C5S9P0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKDRISMKWKQMEILCIIIVSFFLILLVRMMYQPNADSEANSFVSLSGDWYQIKNGERTD
LELPCSVSTNSDGEAILYNDTLTDADIGKFVSIRGVQNHLEIRLGDQILYQYKDDHFQKN
SQMKGKLWADACLSDKTGQEPLCLIFRGRQNSRLYVQVPLIGSYSDIIRHHFQESAFLIL
MILGMIGLGIVSVIIYFYARHRKITEKRFFDVAVFLILCSLWCILDSGIYQMYGKQSAAG
TLVSFYAFMLMSVPILHFIQDTVSKSKRWIPQIWILLLYGNAVLQTVLYITLQVPFVHML
FVTHLILFIGVIAMILLLWQEYRRSQTPVLGLCLKAFEVLGLSGIIALALYWIFSIYWYD
AVFQFGIVLYIAFLFWGLLCKVSDDVQFRLEQAVYERMSLEDRMTGLKNRKAFEQSVNKI
QKEAALLENVLLLFIEIDGLKKINDTYGLQRGDEAVIRTARSIRPVENGSYEQQVQCFRI
EGDEFAVIVSNPQKTPAEWERFIKDELKKETTDGNRVCLKFGYSYLRKTDGTLVSISDWK
MQADQMLLFNKEKESEDKYELL
>A0A1C6F4Q4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MPTSGTDLHQIVNHIPGGVLRCLGDKDYTILHYNQSFLDIFGYTPEEIQRIFHNHYIEMI
VPEDRKAVHDHVRASRVRSGVLEIEYRIICKDGAPRWVLEQCSPVQEDGALCYYCVMMDI
TEQRHTREELRLSLERHQIIMDQTTDIIFEWDIPADQLHYSGNWLKKFGYAPVKQDASKH
IPATGHIHPEDLPAFMALMQSARAGTPYNTAEFRISNGEGRYIWCHVRATDQFNDKGEPV
KAVGVISDIDEQIRMIEHLRKKAERDALTGLYNREETERQIEKYLHDCPENETGALLMID
TDNFKNINDTHGHLFGDVVLTELASAMKKQLRSSDVVGRVGGDEFAVYLKDLPSAELAQQ
KAAQLLALFRTLFAGTDKLDLQVTGSIGIALFPAHARSFHSLYDCADQALYQAKTAGKNQ
YALYDPQRESLPYAAGTSALGADIDSNQETLGVSGGLVNYIFRILYETEDLRDAIHKLME
ILGKRFDVSRVYIFENSLDGRTTSNTFEWCNERITPEKELLQELNYAELENYGDNFAANG
IFYCKDIRELPTSQRKLLASQGIHAILQCAIREKGVMRGFIGFDECTGNRVWTQDEVSTL
SLIAQMLSTFLLKQRAHEQDLAATRRMNSILDSQNAYIYVVDGDYTLLYLNRKTLELDPR
AAEGQKCHQAFYGREAPCTHCPLRHGTGPQQYYNPRYGIWTMAYAAPLQWEEQDAYLITC
FEVTEFMRGHDQKPL
>A0A1C6KXB5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNNAKIDKSKQINDIVSTVKLASLLFTGIILFKYVFVDDVTQVDFPFAYYELISFLLPLV
ILLLIYFIWTFSTKNKLDSKYNNLINKGEIFTFILLFSIIIYISGANESNYKFLYLFIII
TTTIQSGMKYGLVTSIISSIIILAIDLIMMPATEVNIYFENDLILAGIFILTAWPLGFYV
KIEGEHIKRLENMVNFDGLTNVYNHRYFQDKLKEKVEIGRKEDKPVSMIFIDIDYFKHYN
DLYGHQKGDNILRELAVIVTKSVREKDIVARYGGEEFAVILEDTTEKETLGIAERIRANV
EETYFDGEENQPKGKITASIGISIFPDKAKDELELIKSADDALYRAKFFNKNRVETYTSI
LDDLKKNIDDKDIELVTSIKTLISIINAKDRYTYSHVERVVIYSRLLADKLKLSEIDKSN
LIYGAYMHDIGKINIPKEILVKRMKLEKDEWEELKQHPDNGVEIIKSVESLKDVIPLIKH
HHERYDGKGYPNGLTGKEIPYLARVLTVVDSFDAMTSNRPYNRRKSYEEGIEELRKCSGA
QFDPEIAKAFIEVIESNAAFL
>A0A1C5LY34|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSVDRQQMLETAERLNQQMADGIPYTWETLEQALSFVTEKRDRGIHGRICYFAAFYHLDT
GNQEQCLKYLDESVRCLLGTDQEIHVARAYNMIGIVAHMQNNLSLAMEQYGRALDYTAKY
NDKMVHSIVLSNMADAYYLIGVYDRAVQCYRECIREFEKAGDDSIYSRINFRKMLSEYGC
CLLHLDMEQEAMEVYRKLEETGKSEEIVRGTRLAANVFFTYLAESEGHREKAADHVRQAV
MALEDMCQVSSEYDSIQNLLQYVEKTGNIELLQEILDCLEPKAAIEQNRSLLLQLLLLRL
RYCSAQMSIEEFRQATETFFHIKESSEMIESNQVMYMLELRKRLQAAEEEQREQTKKRNK
LLYQSEHDELTGLYNKRSLNRYLEDVFEACKLNEKELGILFLDIDYFKQLNDRYGHGKGD
EGICAVADTLKRIFPEDYVARYGGDEFLVVMPERDLTYAMEHAELLCAGIRECKIPNEDS
EVESWLTISVGGVCAIPKEPNRVWDFLSAADNTLYEQKKEQKGKVRFYQGEGKYL
>A0A1C5KKS8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEKVKRRSGFRRYILSFLIALELLMFFTFLGYIHIPPISITFAYIPVLIGACVLGPAETT
ILGAVFGLASMYKASSNYVMANDKIFSPFMSGLPLESFLLSVGSRVLFGLVIGLVFWAAK
KRKAPRVWLGIASFLAPRFQAFLVYGAMGLFFPETGYHFASAWAMGWSDLPLAVICMLLT
ELAWDLHYSWKPMKEFVAYVEKSRENERQKKILHRAWGIFMVLIIFCATVIVLYFAERMF
VIMNSYGWKLSDDIRQDFVGLQIQSLLAVLSLDFIMALSLLCVYKYMAYREYLVELDYLT
GVMGRKLFFRHCENLKKKYQEHPEKEGWFLFVDVDHFKEINDAFGHPVGDQVLQQIAKTL
QESFADCGEIGRTGGDEFNVILEEETEIRELQKWLDEFLKSVSGAFPSIDKLTCSIGGCR
FAYGQPIEDVYTKADQLLYEAKKRVRNCYVLGKL
>A0A1C5MAE9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MQKRKFWEIVFQWVFPCALLVVALVLSIYEFNNKMNSAIRTVVDDQAEQIGYYYSAGVDD
KLGALGDITSAMANIMASRPDRSDAFVYEKLDTIVKASNAYMSAYCAVNGNGMLSDRREF
DMSELNYYGSISGTSAHYIYAGTDGINGQTAFIYVCPIAISGNVTGYLLSYMNPDNMKEF
FDNSVYGDKAFFSLVNRNGTIMACYGATDGTAILQNDFWNSLKDISESLGSWTLFERQQQ
KGNNGILHVKEDGVGKIICHFPIRGTEWNLVVGINESYLSGIQQSFRGPIVNLIVKISIS
IAVALIIITAINILVRIKASEHSKVLEDKADTDLLTDLNNKMATERKIREYMEKYPDKQG
VLFVLDVDNFKKINDTMGHAFGDEVLRSLAVRLQSMFRATDIVGRTGGDEFMVFLKDIRE
ISMIEREGKKIEQFFHQFEVGEYVKYSVTASVGAAVFPGDGKSFEELYKAADNALYVSKR
HGKNQLSFYKKPGNETK
>A0A2X4VRT1|diguanylate cyclase|EC 2.7.7.65|Lederbergia lenta|TrEMBL
MKINRTNPIINYKSVEEVKYRELFKVTEKFHSTMDISSVLAEIIQTLQKVFPQYEYCLLM
SNDHNNSDDLPIKELEYNSENLTAISSYVNGTVEIENDGDCLHLYAPLKGKQGVYGVLQV
QTDAPAPIKNEEIDFIRLLANTAGSALENAKLYQQSRKLIDDLRFINETSYELNATSSLK
ETIQFLVAKVTSFFSASAIGFIFLEKEEVEVLAESSDFFHEDIAKVFIGYIYEVIQVEKD
GIFIGDTQQLKVEMSCPYGTIMAVPMTAGEAMKGIVIAVAAEPYSFTFDMFKLFQSIIHR
STLAIFNSMLREKLEKMVVTDHLTQLFARDYLNDEIELSMQADHEGTFILMDLDDFKHIN
DTYGHQVGDEVLIQVANLIKDHLRLTDIGARWGGEELAVYLPNVELAIGIQIAQRLREII
SKSTKPKVTVTCGISHWVYGYKDEVKYLFKRADTALYEAKRAGKNRIAVKEIQK
>N9PUD4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 102136|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A8H8ZB56|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A2S8DBJ8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSIQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7Z7MWI0|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MKQSTLSHPVSRADAIRWAGRIGWAMLAVLVAITLSYWYFGVAEILGGPSKVKELMLVSG
LLISVLVFGLTLALIHIRELAQYLMDDMHASLKQSEERWSLALEGIKAGITDWDIPADFV
QYSKGWYDIVEFAEGEVGHRPDGWMQRIHPDDMPRLTEQLQDMLAGKLANPKHEFRMLTK
DGRVKWVLGHAIITHRDAAGKPLRLIGVNIDITDRKRAEATRDALLEAHVDAGVGLFALR
DGRMVFVNPAIATITGYSIDELYAVPNVIDVGVHPDERERIQRKHDKRLAGNMESSRYET
SIVTKSGERREIELAVTLTPNSPDFDVLGIVTDITERKQLAARLQEGHDLLTKISAHVPG
VIFQFRLDPDGRISYPFVSDSVQDLYGLSAAEIREDAHRVSAFLHPDDAEAVMGAFHASA
RNIEPWHLEYRLERPGRGTCWVLTEAKPEKLPDGSIVWHGITTDITEIKNMQEALHNSEE
RFRSLTQMSADWYWEQDENYRFTEISGGAAYGQVKAISEQTIGKTRWEILSNHDDPEALA
RHRERIEKRKSFRNFEFSIPAGDGQSHIISISGEPHFDATGRFMGYRGVGSDVTERKRIE
EELRLAAMVYESSSEAMSVTGADGRVITVNPAFTQITGWEAEEVIGHRVRIFNIDADMFK
TIKSAIDTTGHWHGELWNHRKNGDIYPALISINTIFDENGQPYRYVALFSDITNRKQTEE
LIWRQANFDALTQLPNRSMFHERVGQEIKKARRAGTQLALLFIDLDRFKEVNDTLGHDTG
DHLLLEAAQRIVGCVRETDAVARLGGDEFTVLLADLAHGDNVIVERIARDILDSLANPFL
LGEDEVYVSASIGITLYPEDADRIDEMFRNADQAMYLSKTLGRNRYSYFTPELQASAQNR
LRLITDLRGAIAGEQFRVYFQPVIELATGRIVKAEALLRWQHPQRGMVMPDEFIPLIEET
GMIHEIGEWVFREAVHWAQRWRTGRHSEFQISVNKSPVQFQKEANGHIGWLAHLEELGLP
GNTIAIEITEGLLLDADPAIVGALLGCRDVGIQVALDDFGTGYSSLAYLNRFDIDYLKID
KSFIGNLTDNPGDMALSEAIIVMAHKLGLKVIAEGVETAAQRDLLASVGCDYGQGYLFSR
PLPPEAFEALLLDDKCFA
>A0A378GR14|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MNAFGKQITNNGVTGTRFVRRMYLMRMLGTFLCFLPIVSVLIERHQPVYFELLLACNAFI
WPTVAYLRAVKAPIPRDAEFENLLFDAGAGGFWIAMMAVNPLPSVTIATILLADRLSAGG
IPLMRKAAATMLSVFAGTWVLTGMPFNGFVSQQTMLATLPLISLYLLALSFMTDSIAVKL
RLKSQELERIAMLDPLLDIANRRLLEQRIAWELIRLKQHCGHSLLMFIDLDNFKEINDRH
GHKVGDVMLKTVSQILQMATRGTDTPARLGGDEFVILLPDTSLEEGRGIAQRIMDATAVV
TERPDHHQTLTLSIGIADALPDMHEVSDWLQAADSALYEAKRRGKNQIFAH
>A0A109KWE8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPMQVVRPKILGFISEQASAWLVALMVLLIGSALTVVVAWAASDLYQQQVRQRFQLLVNE
RYTRIQERFEDQEQRLGSLQRFFVNSGEVSRAEFDGFAKPLLLHARAYAWAPRIFRTQRS
LFEQDISRQRGIPFSIRELNTAGELAPAAERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RSALERAQQSGQLAVSQPMQLVGVEPAYAAGVLLVAPVSKLAGAEPYGYVMAVISMRQLV
AEGLPRPNRDNLVMQIVDTSDTQQRVLYASSNALGSSGLTAARRLTLGDHVYALSLSASE
VFDRANHSSMHTILAMGVLLSALLSALLYMLVSQRQRALKLVEQRTVQLRAREQELRGAH
GQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFTAEEVLGHMTLDRLHVAMELDAR
AEPLSRALGKRIPASQAMLVESPDSQHEGREWTLVRKDGSQLTVNMLPTVLLDDHGLWVG
HLAIYLDVTEQKRAYEALAVRDRLLKKLSAHVPGGIFQFTLEPQDTWRFIYASEGMRDIY
EIELGVLQQDAGKVLERIHPLDLERVRASIRLSALQLSHWREEYRVQLPQRGLRWIRGEA
TPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIYNRRYFQDRLKGEMLRLNR
MSGALSLIMLDIDHFKRINDQHGHAVGDVVLQELCKRIGQRLRRTDIFCRIGGEEFVVLC
PNTDGAQAYSLAMQLWQSLRDAAMEPVGVVTASFGVASWRVDEGIDGLLLRADSAVYVAK
QAGRDRVQVCGC
>A0A5E7SKV0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSQSDTRATVLALYPEDSREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGQEPELNR
HLDRVVNDFDYFPPESAAKLFREYIIRDELADARSGQQDAINLVDDMERDVSRSVKGNQD
FQASLGQYLQMLEEPASERLPSILTQLQQSTRLMQGQQEHFLAQLQSAQHEIKSLRDKLE
RAQLAATLDGLTELLNRTTFNRQLEQALSNVATGVALVMLDIDHFKQFNDQYGHPLGDRV
LQHVARVLRDSLPGDAFAARYGGEEFCVVLKDCPDLAAAGAFAERLRLKIQSLRVKARGT
DTVLDTITASFGVAHAQPGDTPESLVTRADDALYQAKRNGRNQVRQQSDVAVGS
>A0A379J2Q4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLRNAKTRPTLRSVLGRGHLSVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFKDRVAATEALALIASTEEVAEARVLDLNGSTLAHWVRPETGVLSRIELELAH
TLLEEPIRQPILHQGQKIGTVELSGHGGSLLRFLLSGLAGIIICTAISGWVAIYLARRML
RGITGPLHSLADVAHAARSERAFDRRVPPAQIAELDSLGNDFNALLDELEAWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRSAAKLNERVAVLFLDSDRFKDINDNFGHAA
GDAVLVAVAARVRAQLRESDLVARLGGDEFAILLSPLHKLEDAQRIADKIIASMDQPIPL
PGNTEVLTSLSIGIAVYPDHGATPGALLNAADVAMYQAKRLSQGGQHTAESEHSAANVQH
RS
>A0A1V4X1E7|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin047|TrEMBL
MKDVRGESSGKKGSADGIRTKDMTVPSRIVDIWQGIVDSVSTLLSVPSVMINRLEPPELE
IFRSNISSDNPFPSGTRMEMAGVYCEAAARRRKMVQVKDAREDPEWADSPTARAGIFSYL
GFPLFWPDGDVFGTICAVDTRKHEWGERYHNVLAAFRDAIEAHLALITAMEELNRKNEEL
RNALGEVRTLRGLLPICSICKKIRDDKGYWDQIETYIEKHSGAQFTHGICPDCVKNFYPE
LDE
>A0A174AF95|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKRFDDKNGTDDKKKRKRILFMAGMIAVIIITAALFYFNSFVMETENSRARDSLLEWTEQ
NAALVGSRIDMYYDLLECAADYISDMPLDEVQTEEMLREKFHRHTEKFDSLKIISEDGRC
VQDGQAYSLKEYFLMAMLGNRGLAENGYSYADGVILSVPVKNEAQQIKGVLCGTLPCSSL
DVYGKADRRKGYAGLFVMDNHGKYIVSDGGNDTFGNDFLTWLEGRELSLPISDIKSQMDS
GFQYYFAISDEDGDYMVTAAPVDGTKLFAVTMADNRYIHQAGLRYRIWVFVITLVIILSL
IVVIGVYLYFRREDRIAIRNLNRQLMLNEETYRITARESDLCVFTYDVETEQIQFLNDKY
QNLGLNQSELSVPVLLRKIREINPETCSVIRDIFARVDSAEALHSQKVKVWAGGRMRYLQ
VKTTNLYDESGKVSRMVGSIEDVTDMENDMLKLQKEARTDLLTGAMNRAAGTSAINRMLV
QELHPGCVNTFAIVDLDNFKTLNDVMGHMWGDRALCEVVLIMKKHCRAQDIVCRLGGDEF
VVFLPDMTREAAEESLRVLSAKLHIDYVKENLEVMISASMGIVFSDGRDITFQDLYEEAD
GCLYQVKRTFKGSYHISDRADRVKAD
>A0A173ZYU7|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKYNQKKKKENVEIFLFIMVMAVFAAVLGVMSLGEKMQPVNQIRKISSGWYYYDNGKRTE
VILPDTIQAEKGEELILYNDGITDLDAGKVVTTRGAQYDLKIWLGDRPIYEYQDTTFVRN
TQMKSKLECVGEIPTDMQNEPLKLVYSNPHHGKYVLTSVYIGTGSAVIALHLQNSGIVIG
IALCFLVLSVISLLITVYLKYRQMPDARFRDVALFLMICAVWLITDSSAIQTYSSHPDML
CTISFYMFMLHSVPMLHFAQKIGGLKKERILDAGIAVFYLNAFIQGLLAYFGVFTFADML
FVTHVLLITWVLIVAALLWKEYRKKPDRSVQIILIAYMILLFSGLLSLSLYWLFEISYYG
AIFEFGILVFLVMIIADTVISLVGKVRYRTEMQAYERLMKEDWMTGMQSREPFENLLAEI
PKTMNEHKDILLVFMDIDYLRRINNDFGRAAGDEVIVAAARCIENVFGAIGKCYRTGGDE
FAVVVFDPEEDRNVLSEKLDKEIRRYNRNSRYRMSISRGFSSIRDDRGKLKTTGEWKYEA
DTNMYQNKMKERKTHEL
>A0A174CL67|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MLNKMNKIEIYVVNEDTDINPSVQEAIEYVLKQNDPVGTVAGYYDEKLTIWSVSNYFLQL
LGWDDLDEFMKASDGSMLSVVCNEQKHIFSPERLHDLQGSHILYLTDSKGLSIPVRIVKA
DARDNKGRPIWVLSVRSDHFARNQEAREAAFHRAFTDMNLCEYYVDLQENTFESMKVRGS
LQEISNKSRTWDELIQMFLNNYVCPESKEAVAQIYNREYIMKELRKITGELSQEYKAVLD
GELRIIRNVVMEGDTDENGEVRHAMIFLRDVTDSKNAEKERRAMLKQNIAMDQLIQGVTR
IVERFAVCDLDSGIYEYYEMNNESYYNPTGDYRELLQRMSGEYVVLTEKINIQMDDLLSP
EHLRKVIMSEDDLYTFEYSTLDRSSYKVMSVIPVEWKGSILSKVMLIAQDIGQKHELEKL
ANTDALTGLYNERYLSERLKRNGKLRKKFAMFYLDLDRFKPVNDTYGHDMGDRLLKAVSR
RLCKCIRKTDYAFRIGGDEFSLIIEEGNINDEFCEMMVRRIKRVIDRPFNIEGRLLSVDT
SCGYAIYPEHSQKIDEIRIMADHRMYEDKTQNRKKG
>A0A1C6KDY1|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MEDKNSELLFEYLRSILYDKKIQPLDVEQLDEPFRKLGRGLQYFAKTFTETKQYAAALSR
GNLSVQPPPRENFLCENLKNIHANLNHLTWQAKQVAKGDYSQTVSYLGEFSEAFNTMTQQ
LKERELKLKQEAEREKIHAGMVETYNQLLVEMIDRSEEEIFVTSADGRRILYCKKRNDRS
IDRNEVYQMCIRFAQKHRSEESRDSFEWIWEAEDSRHHFYRIITGYMQWQGEQAFLYIIR
DVTKEKLREERLRMEANRDGLTQIGNRHYFLEKAGDMLKEESSLTFCYCDLDHLKYINDQ
YGHTEGDWYITFFVETIQKHIRKEDVFARIGGDEFCVILYNCPYEMAERKIRKIQKEFSS
GQTKEYPKSFSCGIVEVEGGNEEMQVRDIIKQADHEMYLQKKEHKKKYRKELSVISISED
>G2FDM4|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Tevnia jerichonana|TrEMBL
MKLLIAEDDLTSRTMLAAVTRKWGYEPIAVEDGEAAWQVMQEDEAPRLLLLDWEMPKLDG
LALCQRIRQQQSSNPPFIILLTARCETGDIVAGLDAGANDYIAKPFENAELQARLQVGRR
MLTLQQELLGAKDALAFQATHDALTGLLNRGAVMQVLEKEMARAIRLSQPLCIGLCDIDY
FKRINDAHGHPAGDAVLQEVTKRIVGALRPYDQVGRYGGEEFLILLNAKQDQAQNLLERI
RRAMADTPIVIEQAKLEVTISCGATLFVPPEDKRGGDALLTIADAALYESKAAGRNCTVF
SPPPFAAHP
>A0A8B6X5T5|diguanylate cyclase|EC 2.7.7.65|Derxia gummosa DSM 723|TrEMBL
MTPDTRLPRFLHALRRRLALALLIGIVQPAPASDNAIRDLLDRADNALRSDADVARGLAL
EALGKLDAAPDADLELRARVVLCDALIETDAAGAERQLAAGRAALKAATSRAYEADLLNC
EGELRSIAGDTPAALRLFERALAIAERNDRPDAAAESLLRRGELRSRNGDLAAAMGDLRR
SLLLFDSVGRQSAAGDALNSIANLYSRLGDDTEAAAAYENLLRRLDPDKSLRDYAVIVHN
LGRVKEAAGDWPAARREYELALDLSRRVGNSRIVGYALRGLAAVRLADHQPDSALDLLDE
AAAQLRKAPDNWLDAQILLQRGLVLQALHRPAEALTALEAATVELERSGALFPRATAHMA
RAQIHAELAQWQAAYENTLRAKAITENVLRSQIDQRYAILKVEHDTASREHENALLLRER
AAIENSLQQERRANRFKLVAIVLTGILAATLGTILLRLRRSAARMQLLAMTDELTGLPNR
RAVLERLDRILGKPSDKPCSVLIADIDHFKLINDGWGHLVGDEVLKTLALLLRSGVREPM
ALGRLGGEEFLVVLPETGLAAAHQVAERLRLQVAALDTRGLCDDRQLTMSIGVAVGLPGR
CSASELLSEADTALYVAKAAGRNRVHPSPAPTTPEPMATPG
>A0A6M5D497|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. MUSA4|TrEMBL
MEQVEHSDNALLLSEWQDLLNQTSPQVHDILTALSDEEIRHLVTAFYDYMLSHPESELFL
NTDQVNSRLSHSMFHWLRSVLGSAGEDLPQLLENQRAIGIVHARIGLPLDLVARGARKLK
NELYRLLQAKATIPASLLSDTLCFSSLAMDTAIEAMTVSWSPGYQNSMQAQEQYRLLSIY
DDVNVERERQINALTSWENQFIYNIATGLPAADIITLSASEFGMWLAHKGRYLLGNREML
TSIDELIKQADDRLARMRASEKQTAESRLSLLQAIRQLTGQIHRLLAAMFDALVELENGK
DPLTQLFNRRFIPTIMRREISLALNVRKPFVLAMLDIDYFKKINDSFGHNAGDITLKSVA
AVIFDHFRSSDYVFRYGGEEFMVLLVESDLSQASIMLETLRTKIAGLAIEVAPGKPISVT
VSIGLAEFDYHPDYKRLIEKADRALYVAKSHGRNRLETSRN
>A0A2C9EEB2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MVNKNPHTPSALPQWPEAAQTLMALMHAQGEVARLTEREQLFSSLLVSVNAVLWAFDWDS
RQVLYVSPAYERIFGRPAGLLLADCNQWRDSIYPDDLEYAERSLAQVLEKGAVEDREYRI
IDAQGQVRWLSDKCFINRNAEPGQRLIVVGIAEDITEKKQLETELQRLATTDVLTQSSNR
RHFFECANREFEQARLQGSSLAFLLLDIDDFKVINDTYGHPEGDIVLQRIAESGRAALRR
GDLFGRIGGEEFAAVFPGCTADMARQVAERLQREIQRQNFSHQGQTFTITVSQGLTGLLA
EDESLDNLFARADSAMYEAKRQGKNRIITG
>A0A8H9NWV9|diguanylate cyclase|EC 2.7.7.65|Citrobacter farmeri|TrEMBL
MDKAHSSPPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQKNLELTAATMT
HSLEAALVFTDDAAAAETLAALGQQGQFSVAEVRDNNQNVIASWRYNAQENDDKLGDFIS
HWLFPLPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRTERSIK
>A0A6S7C2Z8|diguanylate cyclase|EC 2.7.7.65|Achromobacter anxifer|TrEMBL
MPMPGDTVLDPILAELSTTLPEARSVEELTRPLLDMLGEVTGLESTYLTSIDLKADLQQI
RYARNVGQLQIPEGLSVPWDDTLCKRALDEGRMCTSDVSLSWPDSDAARQLGIQTYVSAP
VRADDGLLFGTLCAASASRHDIPAQAESVLKLFSSVIARFLEREMLMEQLHAANVQLLSY
ALTDALTGLPNRRALYEALDRLQARAIREGGSVLVGVIDLDGFKGINDVYGHQQGDAFLQ
DVSRRIAAALRASDMLGRIGGDEFVVIGPGPALAAEEAARGGATQRGEAEAAARSLEERA
TAATVGRYQLGEDVIPYEGASVGVVVLDPRGLDAEAAVRLADARMYEVKRARKAARVIH
>A0A1U7M3R5|diguanylate cyclase|EC 2.7.7.65|Tissierella creatinophila DSM 6911|TrEMBL
MAGNSKINRTPDLDISRQVFAKRVVLILITFVLLSVVIIVLFIYRPLKVELEKSLVNSFQ
ELANIRYISLENNINKGLEGARSMSSRSVIRDSILDYMDKEITLEELKVSNQKKYEDGAK
VLDNLILAERYVEDNLIASYPVDNYEKIDCGSWVNLDKNSQISYEICLEERNEYLKVLST
IYAEDKIIGYDMLLFNLKEQIHNLCTDEIKSEIISQEEMANIIKDAKILKSNGSNILLYN
GGDFYKAFHMKDTNSLIVRQGKEHLLEPIYRTGSHVLFITIGVLIVYTLGIYFFIIRYAK
NELDNSCIDLNVAINKANTDPLTNLCSRRCGEEFLILEFEAFKRNRDSPAIFVIDIDGLK
KINDEHGHLVGDLAIQAVSKKLEDSIRHEDIIFRWGGDEFIGIFHRISEENSLKLAQKLL
AEISSLEITADKGIIRPTISIGISYFFDEDYAYIEVINRADNAMYQSKLKGKNKVNMM
>A0A380QM61|diguanylate cyclase|EC 2.7.7.65|Yersinia ruckeri|TrEMBL
MLTHSESCFSAFLKIRLNWGHQLSLYSRANSRQSGVHFAKRIYIPRIFGLGIGMLCVTSV
LITQAMPVWIWLLLMINGLIWPHVAYQLSINADFPHRQELINLSIDSILGGTWVAVMSFN
ALPSVVILSMMSMNNIASGGKSLFIKGLLLQISSSLLVFWLFNLSFQPETTISQVYSCLP
MIFIYPSLLGWVTFHTAKRLVENKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYK
HCSSLVLIDIDQFKTINDTYGHTVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPN
TTAEQAREVLTRIQGKLAEIEFKQSPGLQLKISAGVAEFKPEMANYQQWLKAVDSALYHA
KNNGRDRIELAK
>A0A7I6TIP8|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-CRE-03|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNALLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYLAKQNGRNQVCTED
>A0A8F8BK09|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. steigerwaltii|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLAGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A8F8BKJ9|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. steigerwaltii|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKVINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEFICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A4D6P8K3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4Y7R6R3|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum schinkii|TrEMBL
MRPKEGFFHFTTSWLVVILAVWQLCRLFPSLDLDQTGELLVIVFLGVLAELLAVSFPHGQ
LSGSFTLIIATFLIYGPAATAWVSGLATIFGQGIANRGNPLRTTLFNTGQYVLAAVSAGW
AFYLCGGAPGLVSLPNALPLIAFTGAYIVVNHLLVYLYLLPQRRRMPHLAWLDTIKWDGL
TYLFTVPLGLLVAMIYPFVGMAGALMLFFSVLGLQVILRFYVRLQVTNKELTAFYETARY
LEENPGSVKILEQVLTNARKAIHYHSAAAYFRSGERDTYLPAAIDGPYAKQLGSTAVYTG
EGITGSVVANREPEIIYDARLDPRTRSDTGLCQVMRSLIVAPLCAGGETLGVVVLGDKRP
LAFDQNHLHIVAVLCSQAAVAVENSVLHDRLGQVLSHDTLTGLINFSSFAELAAELCDSA
GEAGYPVGMLLVDIDRFKNYNLRYGRQAGERVLAELAALVEEDARRDDLIARYGGDEFVL
LLPGAEGARLMGIAEDLRVRVREHAFRRAGGVSTRITVSVGLAEFPRDAGDLTGLLLAGQ
RALDKAKEAGGNRVVAAAVSIVE
>A0A7U5ZG16|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLFFRQGMHDAIETPLAFEVLQDAVSRFNTVRMLPTWQIAVDK
KRTLPINGVSDVFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALMWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQ
SVADIRLYQAKQSGRNRVVWRD
>A0A1U7MIM4|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MPILDTYTIYFLIFMGNLVMCLMLLIFAKTTGFEVLMRYYTYAKLLQTSGAGVLLFRGIV
PVDFSVIVGNGLVFLGIALEVCCIVHIDRVPLKSVVKRWLQVAAGLAVGFALLYLAGANI
GIRAFISAMSIAVYSLVAAAGLFFRSNSTNLRRVVALFFLILAACQVVRALYAFSLGPNH
APFSLSLSQMFAFISIYLHMLISTMSFLLMSREVIDIRLQEAATKDFLTGIYNRAQFMQM
SEKLLSLMIRQQRPVTVFMIDCDNFKAINDTYGHAVGDSVLVNFSQDTQAILRKEDLFGR
YGGEEFIIFSPNTTDSDALIMGKKIQSAILLSAAGDLTIPKYTISIGTATMIPEALADME
KLIKRADQALLQAKRNGRNQIVQF
>A0A8H8X1X0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLAGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A157AAS8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAQAEVINAHKKRFAYWSWNPEDNNDTLGALVSRWLFPVPVAQPIMHNGAMIGE
IRLTARDSLISHFIWMSFAVLTGCILFATAVALAITQSLHHGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMMEFGDKRHQ
AYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENA
SVEALLERADRNMYQVKNQRTKTIS
>A0A330EMH3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLTRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWGSVSLIYPSINIIEAAIGALFLRKWLPWYNPLQN
LNDWIRVAIGSALVPPLVGGILVTLLAPGTEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLINGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNLESARYI
AGRLIHAINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSIMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCNPDKNLHRGLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVTNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A427KSZ0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQHQRVLVTTPHPLMRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWSSINPTYTAINVVEAVVGALLLRKLLPWYNPLQN
LNDWIRLAIGSALIPPLVGGVLVHFLVPTSEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPKLLLETLVTMAVTLMLSWASITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPTALTTQHTNAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLINGDINTYTLEKRYYTRSGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHEKML
PEDRAHAEKVLRDSLIARLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGEKGPLMENIHSGDMSRADIEQDVVLNCRTGGFFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNNGRGVV
TVYEPQQERTHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRAYAAPVARKGLGVALPLSAAGLASATLV
DELLDLLDKGPLPGRLLHLVIAIDVVADPDQNIQTGLQKLRHAGCRVVLSQAGRDMALFS
HLSANMADYLMLDAEVVTNVHGNLMDEMMVTIIQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGIDFIFGDTIGEPQPLDLLLNTSYFAIN
>A0A1S7R717|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. CFBP 5621|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDDSILV
TGFNPSDVLALIGAQTKNAVWLFRYDEAASGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLSASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQSTNGDCES
DAAMLAARVVHAVSRSFGLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEAGMDMAAQHKHALEIDMKSALENHEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLITPDRFITLAEENNFIRPLGEWVLAQACMDAMTWPKDIKLAVNLSAVQLCNDDIV
PVVDRALEKSGFPAERLELEVTETAMLERDSSARGLKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPANPMCSAIVNTVIDMAEQIGLKVTAEGVENSEQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAPIAQDEFGDIGRPTQEIYCPPQKAI
>A0A7W2EQ30|diguanylate cyclase|EC 2.7.7.65|Duganella sp. LX20W|TrEMBL
MALEAATREELQSILAQLKEALNYHQAWYGALVRTLVCGLPGDKRDIDELAHTMCRFGQW
FYSEAPEELRKHPGFIAMGEEHQRLHQLAKQLLLVAGGGNHIATLDYDNFSNALDRMRLE
ITSLERELENSLFNHDALTGAITRYEILPTLREQQQVEKRQTQACFIAMVDFDHFKAVND
RYGHPAADRVLATTIHYLIKQLRPYDKVFRYGGEEFLLCMPHAEPAMSYARIDLLRARIA
ALPIDIGLDEPVHISVSIGLTHLDPELPAATSIERADKALYAAKAAGRNCVREWHPSM
>I6EC70|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGR
>A0A8E4IKP3|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MVHQTSVENRSWHKKLARRLGPGNIVNICFVVVLLCSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMHEALMTPLNFSALQNAITQFQQNRNKRYWQIGLDR
RRTLMINGVSDDFVSQSNLLSRADDDLHNELTAALEVGYLLRLSHAPGAAAQQAMYVSRA
GFFLSTQPTSNSKDILTRYFDFVTQPWFNEQSERMNKSRGVRWFSTPGDHTNETKAQITA
SIPLDNQGYWHGVLAMSIPLAAMRSLLVNATHNDTDGEYQLYDSKLNLLTTSTPEQRKIN
TFDDRERALLAQDIEHDTQGGIRMNSRFISWERLDHFDGVLVRVHTLQEGVHGDFGSISI
ALTLLWALFTTMLIISWIVIRKMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARFLA
QECRENQRPFSVIQVDLDHFKSINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCIVLPCANLAQAQEIAERIRLRLNEQEILIARSTTLRISASLGVSSTEETGDYDFEQLQ
SLADGRLYLAKQAGRNRVCASDQPLSEDKK
>A0A5R8THG4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHQAMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1Y0HQM1|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MGTHTNVVKAVLDSRVDAGIIRTDVLEKMQEDNLISLSDIKVLNTKKHSDFPFLVSTELY
PEWILAKTPHTSEYLTNEVLSTLLKLSTRPKTNQEFRLTTPIDNSKVHALMKEFNIYPYQ
KEPYTFIDALLKYKYFFLGLFIPFIMAIFFIMHIQRLNKKLREHAIEIENFNATLEHEVE
ERTHQLTLLNSKLKELANTDELTRIDNRRHFFLLATQYFYSSKRNNLELYIFSLDIDLFK
QVNDTYGHAIGDEVLKSFCHTIKEIIRQSDLFGRIGGEEFCICIQNTTLEGATTLAEKIR
ESIQNTTTIVGTQELPKITVSIGISSIQKGDNEIFDIIKRSDEALYRAKRNGRNQVQIIL
K
>A0A1Y0HKA4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MMDTETLYELVIVILAIFMTLLYFYYKKKVCVLKLHNTQLEQLSQYDDLTQIFNRRYFLE
IVNYHFKIIHQKNSSAIMMIDIDNFKQINDTYGHLLGDDVLKYTVKQISENLREDDIFAR
YGGDEFIVFFPFISKKDIHTIAARIQSKLEEHKTYDFPVTLSMGICVFSTLSPLINIIEY
ADNALYLAKSKGRNRIEFY
>A0A5K1I3Y8|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MKPGSSRGLGMRLVVVFSLIATLCALAFGYYVSQARQHVGADYTALVTDVVRAQQDPAAL
RMGLDSMIDHSDRMHLEQVHDVLWRIPRRIESVKRQLRGSELVPASYEQLFEELSYVESR
LPALETAVDRVPEEGLDEADGEAILALGMEIEEGLAWAYSELNEQLHQASAEQRVLMGRL
TLAVALLLLMLLLAVGAVMLMLLRLHRQRETMRLQSRTDELTSLSNRRWLRETAEQAFEW
RRRHGTPLSLMLLDLDHFKRINDDFGHPLGDAVLVTFSRTLERHVRRVDTVARMGGEEFA
ILMPDSDLAGAEALAGRILRATRAMPLPGPAAHRRLTVSIGVVEVGDEMGFDRLYSRADQ
LLYRAKESGRDRVVTERDQVSAAPDTDGADRHDGMGITQQPWAGGS
>A0A7W5SNT5|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK602|TrEMBL
MIRTVERGALKSLAVGLLFGLGGILSMSDPILLAPGILHDGRSILLVLAPLYSGPLGTVV
AAVMMAVFRLAIGGIGAVGGSASILIVALTGYLLTLLPRQWLGSGWKQSALFGFSTMTSL
VVLLFLPSQLAWELLVSATLPVTIVNILGVILLSDLLQRERYRVGIQRALENEASVDPLT
KLPNRRVLQREGDRCSKEAGSRRTPFSIIMLDIDHFKKINDTWGHSCGDTVLAKVADVIR
RTVRKTDVAARYGGEEIVVLLPNTDENAAMIVAEKIRRDIEAADLAFDRDIIHVTVSIGI
ACSNEPTTDFKYVLEAADKALYRAKAGGRNRVELSAAA
>A0A1V5TS40|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin262|TrEMBL
MPLLLYYAQTDLFAILMLLILLLNMRRVSDLKSQPARVFSLLVWSIILNIAADFAAHALD
GFQSAAAIQAAVVLLFMLNPVTAYLWFLYTDYYLFGSEERLRKLALPAAAPLAVNAVFAL
LNPWTGLMFTLDEGNAFHNGKFIIVLYASIYIYLLAAMVQLIHNRKKLAKGELLPMLLYA
LPPFAGSLVQANYYKVLLIWPLTALSLLVIYTFVQSKTIHTDHLTNLFNRREFDKRLAEL
ADKKHTDNLLAGIVLDIDNFKQINDRYGHKAGDSALRAFCAVMRDSFRQYDFVARTGGDE
FAVILELKTATQLDRIIRRLQANVDAFNKTGTLPFPLSVSTGSGLYDPSTVSSPAVFFEM
LDARMYENKKKKKQEG
>A0A5K1I830|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MAFQQKFAQPLRHALHRHLFSLRGRLLLGVVVIWTLLCLILLALGWQSGTLLVEESNRIH
LRYEANLIRNDITHEIEQRLEVLDRLADQLPDPSPGSLAQGNHDPLLALFEGLVVVDAEN
TVIDDWPTITGRIGRDISHRTYARFMRNIQRPHVSEPFVGEVSGRLLVMMLVPRHDERGR
YAGFLGGLVELDHSELFTGFDRLRLGDEGHVVITTTSGRLIYHPDQRQNLPTRDDLMEDP
WLDLALDGWEGEASGELHEGGSALTAYRQIWPADWILGLYLPLEQVYTPLTNVMERIALR
ALWVLGLLLPVMAALIWLVLRPLTRLAHQIKDLRHGRRRALQIATRMHELRRVIDVFNEV
EQDRARTMDDLQRRKAFLKGILAASPQAMFVTDTRGRLTFVNRALKDLLGIKPPVHLPVW
AKRIHEEDREPLVAAWQACLLQQKDLVRQFRYFSKEGELYWLDVHANAIRVDGEIIGLVG
IVRDITQRQHEDILLRWEAEHDPLTGLLNRRGFQRRVEEAFAAWEKAGTPSSLLIFDLDH
FKAINDTGGHALGDRMLQQVSAAMVAETRNSDHAARQGGDEFAILLPGCEASRALRIAES
LRARIAANGLEQNGQTWRVTVSIGVGSFQGTDQTIDDVIARADAASYAAKSLGRNSVVGE
>A0A851G3G2|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SECR19-1250|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRTRPFWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDNELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTDTPAQSADIIPRYYHLVTQPWFTQQTERNNRARAVLWFISTPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRLLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIESDTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
AQCQAQSLPFSVVQIDLDNFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKEILVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDQDKK
>A0A735ITT4|diguanylate cyclase|EC 2.7.7.65|Salmonella typhisuis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1Y5RFX5|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MSLIFKEMLMSFVDSMALLMALIFAVSLLQRKGGDALHNTTFMGLLFSFALVMSMSDPIH
LPNDAGIFDMRALLVGTATAILGPVVGAMTLVTGVTYRMYIGGAGVAPGILGMCAVFVSG
WIWRRFVKDLDIAKIRKSIILGLLLSSQAAAFLLTPPAVTQVLFPSLFPYMLVSSLAGAV
LIHSLLTGEFTYISEAQASLIHANTDHLTGLLNRRGLDLAYDQMTQREGRRAGQALLYFD
VDRFKTTNDTYGHAVGDDLLKHIVSMISRNLRMDDIFVRLGGDEFVVILPDIDAPEAEKI
AERCREVVSAANFDVAGHILPVSISVGAVWMRAPTEVDKMLDAADRALYQAKAKGRNAVV
FLSGLRRVDLIHKAA
>A0A7L7IJP3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00175|TrEMBL
MNKQYQRVLVTTPHPLLRLVFLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNVFASWMILSWGEISLAYTVINVIEACIGALLLRKLLPWYNPLQN
LNDWIRLAIGSALIPPLVGGVLVYLIVPSPEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPRLLLETLVTMAITLVLSWLAITWLPWPFTCVIVLLMWSAVRLPRLEAFLVFL
VTVMMVSLMIAQNPAPMATQNASAMVNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYTQTELQSLTFQQLTWPDDLNSDL
EQLEQLINGDINTYSLEKRYYTRHGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKKMFELYEIPPHIKPTWQIWHESMV
PEDRPYAEQVIRDSLMARLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWTQVEAIGQPI
LKVLHITFGENGPLMENIHSGDMSRSDIEQDVVLNCRSGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHAINDYHFMWEGRLHRIGASAGITLIDENNYQAAEVMSQADIACYASKNNGRGVV
TVYEPQQERVHTTRGMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLISLRLWTSQ
GEVQEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVASKGMGVALPLSEAGLASVTLV
DELLELLEKGPFPGRLLHLIITIDVLNNPDPNVQNGLQKLRHVGCRVVLSQVGRNMDVFN
QLSINMADYLMLDAEVVTNVHGNLMDEMMVTIIQGHAQRLGMKTIAGPSNQPMMMDTLSG
IGIDFIYGDTIAEPQPLELLLNTSYFAIN
>A0A8I2CW85|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium|TrEMBL
MGASLGQKKTRVLIVDDEQETLDLIAEYLKDRGFDITTTMSGEEAVAIVQKDLFHIAVVD
LHLPGMTGAELLRSMKSIRPDVQVVMITGYGTIRDAVECMKLGASDFITKPILLDHLHLT
MRRILEEARLKEEAELADYYRNLSRTDELTGLYNFRHLMTVLKSEVSRHLRYSRTLSLAM
IDIDDFKRFNDAKGHEEGNELLSNLSHIFKHNTRNCDILARYGGEEFVIIFPETAIDEAL
VVSQRICSTVVSTLGVSVTIGLSSLPQNSSDPHEIIRMADAAMYWGKTHGKNQIVVFEDA
MLTCR
>A0A6H0KCD7|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei|TrEMBL
MNKDIIPSQRPTFKRTLRRISVISVIITMVLVWLLLCIASVLTLKQYAQKNLELTGATMS
RSLEAALVFGDNTVANETLATLGKQGQFSEAEVVDRNHQRFAYWSYRPGEEQDTLNHLIN
RWLFPVPVSQPIWHNEQFVGALHLTARASLISHFIWMSLAVLTACILLASAVALLVTRHL
HSDVVTALQNINDVVHDVRTNRNFSRRVPEEPIEEFHHFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRASFLSCIAALMNDSNAKTSSALLFLDGDNFKYINDTWGHAA
GDCVLIEVARRLIEFGGKRHIAYRLGGDEFAMILYGVHSEHEVQRICTALAQHFVHPFDL
RNGLYTPFSLSVGYALTWEHNSVESLQELADRNMYLMKNQRAKKTT
>A0A3S9L536|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MTLAGRLKLAVIISSLFLVVMMGILSYIMYLDNQGYNNSYRYQELQITLSQLSGELWQLR
QYEDFQALERAIDLSLTLDAQLLELNQHQNARLGHIEKANTNLRTLMGLYPRTQDALNSE
NLNMLMARINTILLSMQDEVGELRHQLVARQHEAKKLMLVVIALLLFMSKTVVILFNLNT
LKLFRRGLDNLESGIRQLASGDMASKVPEEVENPEFTTLSQHFNRMKQELKDSTISRADL
QDEVNKRTELLQLQKEKLKYEAEHDPLTQVYSRNAFARILEQSLKRLQRNGGTGALLFID
INKFKPINDNYGHNIGDHVLITVARRIAYTLRQSDMISRLGGDEFVVWLEPIESPKQLDV
VVEKLLDKLHQDIGFQNVHLLIDVSIGVAFYPEDGSNIEALLEVADKNMYACKRGAPKGY
VSSSPR
>A0A8J7VW88|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
YASGRLEIHADAVAAGQRELLRWSWRCGLVLLALACLLPAAAAEGAAGAMVLGSPSVNEG
HATRCRSGDASLARTIEIPAPRGGWSGHPQAVNVINAVSGEVVIEHGTRRVCGTMLDART
LDSRFRAGVGTVLVPPAGDTRPIRVRLEAQVAPWRPVVRIGAPADVQREDTGRFVVRVAA
LAVISALALAALLSFIGTRETSFLSYVAYALLFAFWMALVCGLAGYPEPWIEMAGNSRRA
IVGLGMLVVGGVFYVLCKFSGVERRLPRMRAPLRAAPSLAGVGAAGAFLLPDAALGPAAG
ALLCVFVASAGLAVLAGAVSMARGESRAVRAVVGGLPFLAIFGSVAAGSATARAYELELL
VTAGTFMLLIAILGLQLRLGSLRRQRDAMRVLADTDPLTGVENRRAALARLEDLIAGCRA
GGAGGSIAFVDIDHFKTINDRHGHHMGDRVLVEVASVLRAHVRVDDHVARMGGEEFLVVL
PGVAPEVARARIAALCPAIGAAGQRLDPPVAVTASVGVAHVAPGVESVEALLRLADDAMY
AAKRAGRNRIVEALPAEAAAG
>Q0T3Y8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7C1VX33|diguanylate cyclase|EC 2.7.7.65|Methylophaga aminisulfidivorans|TrEMBL
MQSLTRDQLQSVVNEIDRATEKHQSWYESLLRVLICHLPPQENDLAVDAEQRCLFGQWCN
SPDAGLIIEHETFKALARAHKNMHDSCRMLLEHMIQRQMIPVELLDSFTAELADMRVQFE
SLRHEFSERISNLDPLTGANTRAGLMAILNKEHSLSVRGYPSASILMIDLDYFKSVNDTY
GHSVGDKVLVSTVESIQKTLRPYDSLYRLGGEEFLVCLPSTDMEQASIIAERIRESISTT
HIKLEQNKQSIRVTASLGVASLCPERNVVDSIELADKAMYLAKQEGRDLVKVA
>A0A2N7R7E4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MLAPEKPVNEQARVATLRGLNVLDSAPEERFDRLTRLARRVFDVPIALVSLVDTNRQWFK
SCVGLDASETGRDVSFCGHTILGDQILHVSDAALDERFHDNPLVIGAPGIRFYAGCPLRV
SDGSKLGTLCLIDTKPRQLDDEERELLRDLARMAEQELMAVQMASMDELTLLSNRRGFKA
LAQHGLDACARLDKPATLLFFDLNDFKQINDLYGHAEGDSALKTFADVLRIAFRESDVVG
RLGGDEFVVLLTGSSHIETTAIMTRLKDILDERNAMLQRGYDIRFSVGQIEYDPQRHDSV
DRLLADADGAMYAHKQALKRH
>A0A3Q9E3G7|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MQSYGYHSFREIEVDEIDWQRWQRLVNTVADMFKAPAAFINQANTKGIEVLIASELPTTL
YAPGEASPINSNVYCHYVVQHNEHLYVPDASRDPRWLDNPEYLEDNYISYLGMPINWPDG
NTFGTLCVLSDITTDYPGTYLKVLEVIRDVINADLAHIYRESQLLTETYVDPLTRIYNRR
GFEEMFTQNQQLAKRLGRQMVLLSFDLDKFKPINDSLGHDTGDKVLQYFAQSLKHSCRSC
DLVARWGGDEFLVLAHSETDQLED
>A0A645EVU7|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLQQSLKLDELTGIFNRKALHDAMKNFGDYNPKEKHVFAIIDIDKFKSINDNWGHRTGDR
CLIEFARILRENCGNAVPFRYGGDEFCLLFHDANIEESIYTCEQIRTELKNLDIGVDPKL
EITASFGLAEYSDKINIAQLFINADQALYKAKILRNKIEVFEG
>A0A2K4ZIH6|diguanylate cyclase|EC 2.7.7.65|Acetatifactor muris|TrEMBL
MEHSLPLLINYIQGILDQTKASSFRREDLSPDFRELGDKIALLADRVQDLTNQLQQKNEA
LELENQVLLDNIQAMDEISWALEQSNQELRINLNLVNALTDYTHNMIFVYSADTGQEVHT
NQPARWFQKAHAQNAAQLTRQLLDKQPEIQEQMDLHRENQKPDSAELPDGQFTEEQELSD
RSQSSLRWNMALESPDGIDLFYQVESFLIPWFHSNEESSQDAKKQAIVHIVLDETERQRR
QNLIYRFAYVDPLTNLNNRRYATEKMEQWQHEGTAFLLSFIDVDYLKYCNDTFGHEQGDS
YLIEVSAALQTLGGEVCRVGGDEFFLLQTGLAPEEQDEKLEKLRQTMLADKSSGYPKCFS
YATTLVPAHSTIPLVEYISNTDAKMYQYKQMYKIPLSDVVYKDDRI
>A0A0U1HT78|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MNELESLSTLYRDICVTYATLSISYLALSKNSTFSYDGGVGKRIIFGLISGLVSLYLNED
QWVISDSFFYSFELIPIILVTFYGGWLSGLTAVAVNIAFTGWFTLDNLLITLIFTSLILF
KVWEKKNNRVFYTTVVLIVIYRVVAAGLLVPQALNWSQVMIYQLISVLCLAICYHALNFN
EHHIHTFFTMKFRASIDKLTQLNNRASVDYRLTTIYNNRQACGLMILDLDHFKFVNDTYG
HDAGDVMLSEIGRLLTEAIRDEDFVGRYGGEEFIIITHRHEPQTITAVAERIRQLVENLT
VELPSGEKIKATMSIGASLYLPGMSMLKALKMADEALYQAKRQGRNQVVYSRLMPYSVLG
DNIAKEKYRR
>H0TAM4|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. STM 3809|TrEMBL
MIDLLKIELVNGLNVKMEEPSLLQHKIEALERSQAVVELDLDGTVLRANYLFLQLTGYGN
NQVVGQSYSMFVPANENQMSEYERLWTRLRSGEHVAGEFCRMNSSGHPMWVYGVYCPLLD
DAGRPYRILKMVADITATKRRDADFAGQVAAIRTSQAIAEFDLDGFLLDANQNFLQMMGY
PLENVRGRHHSLFVDSSERESVEYKAFWWRLRDGNYHAGLYKRLDASGATHWIQASYNPI
RDENGQLTKVVKFAIDQTSSVLDHLRVEYLYRHDALTGLANRAGLKLALDAIYSQRDGAQ
PTLLLVDLDHMKAINDTLGHLAGDQCLITLAERIRNAAGNDTTVARLGGDEFAVLLQNGS
EAAEIIAQRIVAAACEPFEWMGGLYQVGASVGVSSEGDNPSDLLKYADIALYEAKRSGRS
AYRRFYKASPLSSPELSPTADLVVAT
>A0A2P5GVP0|diguanylate cyclase|EC 2.7.7.65|Superficieibacter electus|TrEMBL
MEKRQWPGKPGLRFTPGQVVSLCFIVVLICSSFLTWREVRVLEDSYVSSQRNRLESVSHG
MDMQLQFNMDRLFFLRNGMQAALKTPLQLESMVTARRQFDWKRQQDAWSLYSGSRLLLTV
NGVSDEFVAHGADLNRDDALLHNELTAALELGYLLHLSSSSSSIEQRTQYVSRAGFFVTS
DPAEMSDIISYYAGLIGKPWFFTQSARDNRGRGIRWYTEQGKERGVQVITASIPLDLNEY
WYGVLAMDVEVSALQRLLMEAIGGQHEGTWQLYDSHLLWLASSVAGAENGPTLTAADRQH
ILDAMEHDTRGGFLTASSYISWQKLKNFDGILLHVHTLREGLGGAFGNIIIALTLLWLVF
TLILILSWIVIRRMVRNMIAMQESLEWRAWYDTLTRLPNRGALFERAAEAARVCQQAQQP
LCVIQLDLDHFKSINDRFGHQAGDRVLSHVGTLIANALRENDVAGRVGGEEFCIVLPNTS
LDMAVKVAERIRKRISAKELLIRKNTTLRVSASLGVSSSEESGRYDFEHLQSVADGRLYL
AKQNGRNCVYCAG
>A0A378SSJ8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MAVISSALVLMAFGVLGSRDEHPVLTYTVAAAAAIAGIGYGTLWLRRWPTRRQSLMMGMV
GGSMIAVGSGMQTEPVVALMGCTGLVVTGGYLAFFHNTKAVLFNFAVAATVGTYCALRVF
ETYDDRASALAGLWLIIELNLAVPLAIQTVVRTMGADVVRSDHDALTGLLNRRGFYERAS
SLLTSPAADSDLIVVMIDLDAFKRLNDTYGHLAGDQALAAVGWALRKASPGSAVIGRTGG
EEFLLIDILPVAQAEALPDELCAAIAALPHPVTASVGAAVVRGLPQSDAPAVIEALTRTA
DATMYEAKRSGGNQALIRRVSPLFQN
>A0A822PLZ4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A4P9DFL4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4742|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A1F2M826|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. HMSC16C06|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEEIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENNAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A0W0Z1B0|diguanylate cyclase|EC 2.7.7.65|Legionella santicrucis|TrEMBL
MVFPVVMIVLGIVLLISGAYLINKLLQKTNHYRRQWFSYLAFIAVFILSYSASIFYGLLV
DPHCLNNFYASVLLLGATYIYSSCRLMTNTIQKMELMDDFKNRYEVLRHHATYDSLTGCN
NREYLFEMMNTRFQQVKMNEGSVIVLFIDMDRFKTVNDRYGHEVGDTTLHMFGGLLRQRL
RRDDVVARYGGDEFIVLMENTSMDEAKKIAENLITVTKKSLKEGTLSELNLGCSIGITQM
NHHSASVNTVIKEADLACYAAKQRKINGSVCVYNSMITTKNNAINFSGNQITP
>A0A2N8KDY6|diguanylate cyclase|EC 2.7.7.65|Achromobacter pulmonis|TrEMBL
MSISSFGIPSSPDRSEAMPAQACYLSASHEAAWVAVYQSVDAYTRGQVAAVVGDSLPQLV
DTFYSVLLADAEAGPRLSHDIVATRLHSGMTHWLKGLLCVRGQGDIGALMATQKKVGEVH
ARVHIPMHLVMVGARILKNEIAQRLRASDLDGLAASVATQYVCNLFDLAVEQMSRAFMRD
VSRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQALPRLAASEFG
LWLQHKGAAMFESAPALQQITEAVAQLDRDVLPRLMDGAAASMTDHVRELQELVARIKHL
LNGLFDMVAEIESGSDPLTNVLNRRFLPSVVSREISIAQRQRTEFSVLLLDIDHFKAIND
QHGHAGGDQVLRQFAQVLHQSCRSSDFVFRYGGEEFLIVLVDAGREAALATAQKLGAEVR
RQEFSVAEAGPLRITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSEAA
>A0A737DTZ4|diguanylate cyclase|EC 2.7.7.65|Salmonella potsdam|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSAHSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAERLQELADRNMYQAKHRRAERSLN
>A0A3T3ET90|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A656AHA7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDHRFSTKLFLLLMIAWPLLFGSMSEAVERQTLTIANSKAWKPYSYLDEQGQPSGILIDF
WLAFGEANHVDIEFQLMDWNDSLEAVKLGKSDVQAGLIRSASRLAYLDFAEPLLTIDTQL
YVHRTLLGDKLDTLLSGAINVSLGVVKGGFEQEFMQREYPQLKLIEYANNELMMSAAKRR
ELDGFVADTQVANFYIVVSNGAKDFTPVKFLYSEELRPAVAKGNRDLLEQVEQGFAQLSS
NEKNRILSRWVHIETIYPRYLMPILASGLLLSIVIYTLQLRRTVRLRTQQLEEANQKLSY
LAKTDSLTDIANRRSFFEHLEAEQTRSGSLTLMVFDIDDFKTINDRFGHGAGDNAICFVV
GCVRQALASDTYFARIGGEEFAIVARGKNAEESQQLAERICQRVAEKKWVVNAQHSLSLT
ISLGCAFYLHPARPFSLHDADSLMYEGKRNGKNQVVFRTWS
>A0A655XDQ9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSDQDLQGYVSRILDVIPLPIIISKSSVLGQGEREHLHFNKAFVKELGYTMAQIPNIETW
FERAYPQIDYRQEIIAQWQKTVDEARAQGEDVAHMPALIMCADGVQRWFSVSAQIEPSCR
DDLHIITFRNIHDYKISLAEAERQSQIDPLTQLKNRRGFFTWSEPIAPETLLGLIIFDID
HFKQINDTYGHPAGDYVLRQIAGLLEQNLPPLSCCVRWGGEEFLVCFECDDMANVIGLAE
NIRDYVESHTLMWQGQQIALTLSAGCTMGAMMSHNWDNLLHTADQALLSAKRLGRNRVIA
DR
>A0A0H9ARR9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVHSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0I0PNL7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A377QWX5|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MTDALPAAPPAALPEVLFSRLLEDALDAVIIIDEQCRIRYINGAMQALSGYASGELLGQT
LNGLLPDAVGAQHDNHVINYIRSSRTSSVLGKIREFAIRHRDTQMIPIEMKALDLGVVDG
MRYFGAFLLDVRERRELAAKNASLLAQLEQQALHDALTSLPNRRAYEAQAEQAMARAARS
GAALSVGVADLDHFKKINDRYGHAVGDAVLRTVAQALRDTGRITDVAARLGGEEFGLLFP
DASLQQAHQVAERIRAAVAAAVTVLPDGGALHVTISIGVAPLVQGASLDAAISDADKALY
VAKHQGRNQVVAAAASQ
>A0A090G9V5|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium plurifarium|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTASNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRDFATGDAKPRVLLVDERKSSVERIQKMLRNSAE
LDVATDPNAGFFQAAETPYECVLVSTAFTGFDALRLCSQLRSLDRTRFLPIMLLADEGEE
GRILRGLELGINDYLIRPIDQHELTARLRTQVRRKRYNDQLRASVAQTIEMAVIDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDTYGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGPVAEKVAERIRAEIAQAPFAVGNDGKTIEVTVSVGV
SSLLKGTDSVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A5F1EX30|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMSSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A2T3RXD1|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A8G2N7G4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITNVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A291E2G0|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MTAQTWRALLKAKQLLSLRLFLLLNALAAAFSMFFPLHSAVRITPPVIAILLISLALLGW
QMMNKKLLINLNFVSLFLGLLWAIHIFIKNAAIGDLDTSFLVISLMSVLFIGAISFINNI
VPFLLHCLPAALVVLCLGNVDQWLRVIYSIALPAIGIAIQHIIQKRNDRFTQRLMNKLLE
EKETLTDLSMLDPLTGLYNRRGFQNRLEHIQASGHGSHYVLLLDIDYFKSYNDHYGHAMG
DQALIRVSAAIRDAVRSRDIVTRYGGEEFMIMLTNIDAERAMQSAERIRQRVFDLDIPHM
FNNQVATNVTVSIGLAPFIEGSIDDALSLADKALYQAKNRGRNSILTTEMATVS
>A0A7Z7QQW2|diguanylate cyclase|EC 2.7.7.65|Staphylococcus schleiferi|TrEMBL
MIEAIIYNISVTIAGIYLFHRLQYAESHDFRFSKSYITVLMTIVGLLLALYPVPIEHYMV
QLSFVPLLFLGRYTNSFYTFISAMIIALVGYFVLSTSLTYAIALIIIAGVVSTIGPFLKQ
NHVVAIQILNVLSIIILTVIALFMPSYDIKEVIYLIPLSVIATLVTAIFYVDLLRFFSLI
ERYENEETVDYLTGLGNVKEFDRHLNEVSRIADDNNQSLALLLIDIDGFKDVNDAHTHRA
GDAVLKQMSHLFQNYVPKKTKIFRNGGEEFSIVLRHYSLDECVKLAENIRKAVEKSNFHL
PDKTVIKLSVSIGVGYLDSDAHKSHRKVFKDADDMLHVAKNEGRNKVMFNPIIKLQ
>A0A0J2KQZ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSQAILVDGRQRPFASWHNDGLVSQDKISDVIS
KWLFPKPTVQTILHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINDLMKDETAQSHSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAVLLRDVHSETEVRALCSALSEQFIPPFNL
HNGHTASLSLSIGYALTWEHTSAENLQELADQNMYRMKHQRLQQTQK
>A0A5I0RXI8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Uganda|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0J2H0Q3|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MTAQSWRSHYEQKYQYSLRLFLLLNLVSSVLSLVSPLFTVITFTLPCFLIVACSTVLLLW
HCKFSQHKINIPVISLLFGLLWAWHVALKAMVMGPPHFNYLVIALLSVLFIGTIAFSSNI
IGFTLHSLPTYLICLILGGGEQWLRMSWCFLLPIAGITLQSLIQKRSDVFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTILSLDGAGHYVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTSSSAENALQAAERIRQRVYDLKIPHM
FNESVATNVTISIGMTPLMDADIDSALKRADNALYEAKNMGRNIILTS
>A0A658Z1Y8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHT
>A0A3T2YR36|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F7YDN5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A484P0N7|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MKHSTEVMALDWAHTHSRYSAEQCQLAQDVSARHTAALADDFYDCMLADQGAAFFLSHEL
VQTRLRHAMQEWLLTVFDARHLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLTRRM
HELLHAEPDALPHAVLGACRYISEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSANLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHHPPGSAQRAQALQGIRDATQAVAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPLSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGLQALSVADALRRRVQERPMALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAEDDTDMPSGAPASHAAGHQPVRAGA
R
>A0A426WI82|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A447MYQ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A6X7VNS9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379VV20|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A444I3V0|diguanylate cyclase|EC 2.7.7.65|Rhizobium leguminosarum|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPTDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLTRAGEGRADETAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPVLIITEQGAD
DMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKHVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAGVAERLRAAIENAPFMLKHAGEALNVTASFGI
ASRITSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A5I6C9P6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hull|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3T4JRF2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFSPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2T6X0S4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A220Q6W6|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVSNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPMAFSSTQLSVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A1C0P2Q1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>A0A3V4Q2G0|diguanylate cyclase|EC 2.7.7.65|Salmonella thompson|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLVSCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A401AM57|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A486I206|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVGASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A5W8G5D6|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V2HXF9|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A828NE91|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LVDWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLVDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAENVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A1D8F780|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQAGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A2X3I7U3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A377N052|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNQYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDAVNFCESP
>A0A376P834|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPETRNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0Q2YSK2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8I0NQ29|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLQNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A024L506|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A0L1CD86|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSLSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A376JBC0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIVCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2A6Q2W6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGILVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQHADAHSERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIFDEQTFRRSFSDPALNHALDRRVLNEFFQQTAKAIASKGLSIALPLSVAGLSSASLV
NELIEQLENSPLPPRLLHLIIPAEAVFDHAESVQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNNSYFAIN
>A0A7A3AZL7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQAAPIIRTKAAEIAVTHAHYLSNEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFNQTILHAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASETDTLRTAERIRSRVEKTKLKAANGEDIVLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2G8ZWM3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQRRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIVDAQPLDLLVNSSYFAIN
>A0A1M0D124|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLADVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A024L437|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A789RN23|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGGEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A2J1D8D5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDYFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2K4P9F7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFL
LQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSV
LIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENE
TLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRG
RNRVELWKASL
>A0A2X6CQH8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYRDWLKSADLALYKAK
KAGRNRTEVAA
>A0A5K1IVG1|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNTSVVKKASRAVRLLMMVLTAVLIFFFINVMLLVSDIQGTARVVNYAGLVRGTTQRIVK
LEDAGQPRDDLLRAVDSYINGLRYGSDDLNLVRLDDDEYQAKMTELANYYDELCAEIIRV
REVGYENTDIIAMSEEFFGICDDATRLAEDYSQEKASALNYLEGLVIIDIVGLVATFAVE
LVRAVRTAALNRELQNKVYLDEATGLPNKNKCEEILGQEHPVSAEAPVALCVFDLNNLHT
VNNSFGHEKGDEYIRSFAQQLGRVASETCFVGRDGGDEFIAVLWDADRAAVESFLARVRA
NVNEHSEAHPDMHISYAVGYALSSDFDELPTMRELFSQADKNMYIDKNRAKTAEAAGPQR
EER
>A0A5I1CCT2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bredeney|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A826YAQ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377CL54|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKYEPVSALRLFNYCLIAA
LLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMP
AIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVID
ISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG
LYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA
RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTL
TDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2X3JHY8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQ
INDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEK
RLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A853T3A4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MSSKLPSSPAGAPAGATNTAAAAAMNPADIAREAFRRLATRRIAPTPSAYRDIYNEIAGI
SEAAETPATPGAVLAASAPTESGAENVLTQFAAKMSESAGELGDFGKRFQRALKARDWDG
YARTLAQLAEKQVKKSGGIELPPLPDGEQTRTLRELLSRTLGFAVATLLTGTPALVEEAE
SLGAAIKLAHTEEALNEAALRLKQLCYQIELKSGDTAEQQELLLRLFKLLLDNVSQLLDD
DSWLRGQVDAVQNLIAGPLDQRALEDATRSLKEVIYKQSQLKHSLSDVKLTVKNMMMTFI
DRLGQVAASTGDFHEKIGGYSEKISQAENISELNSVLDEVLRETRMVQNEALRARDKMVL
ARQEVQDAEQRIHTLEAKLQHMSELVREDQLTGSLNRRGLDDVFERETARSDRRGTPLCI
AMLDLDDFKRLNDTYGHLAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILLPETTVEA
ASSTMTRLQRELTRHFFLHDNEKVLITFSAGVALRLPNEDQAELVKRADRAMYQAKQTGK
NRVVVAD
>B0NHI1|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain ATCC 35704 / DSM 5676 / VPI 13733 / 19)|TrEMBL
MDEINRYKERLQIALTAAKICIFEVDLLQQLYTYFENAEVIFGISGEKILKDVQPFSKLE
PVEYRKAASAYFSHPEDEAVIEKAFKDILRGKESTYEARMRAGGSGYVWCRIHATPIIEN
GVPARMVGVIADISDLREQTENLKKAVNMDAFTELFNKEYAIGLISEILRKSKDLNHALL
ILDIDNFKNYNDTFGHSEGDKVIKAVSRKIRDTFRETDIMGRFGGDEFILLVRDIKNMQW
LNRKLSDLTCFQVGDITCTTSIGISLFPQDAARFKELFAKADAALYQAKAQKGIFIYYHE
>A0A5Q9LNZ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEEIHTECSAIM
QDADERMYEIKKGKR
>A0A087BS50|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium longum subsp. suis|TrEMBL
MATIFIVDDDQAIGEMLSLVLENEGFQTVTCLDGLRAVEMFPIVKPDLILLDVMLPGLDG
TEVARRIRATSNVPIIMLTAKSDTLDVVAGLEAGADDYVPKPFKVAELLARIRARFRIAK
PAAEDGATGGASGGNANVNHLERGPIVIDRLEHTATKDGKDLNLTPMEFELLFMLAAAAG
EAISRSSLLKNVWGYENSGDTRLVNVHVQRLRAKVEDDPENPQIVQTVRGIGYKFVTPEQ
>A0A737MXK3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi C|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0W0R0M2|diguanylate cyclase|EC 2.7.7.65|Legionella adelaidensis|TrEMBL
MEMPVKKNQANTYFRTSLLTIVFILLLLCSFVLYLLYVNQKLENIERNRLSSVNVALEIL
NHSSTLTEMAHYYTATGDSKYKNYYEDVIGIRNGTLSKPTYYSSFYWAYVLGGKRNHVAS
LVNNGKASATKELKLSELELDLLKRAEQRANKLNSMEHRAFILLSGSTEKNKKEAEQILF
GSDYLKARANFLETIEELTFAIDLRTKNNIMYIKRVEKLTSSLFIILAIAAIIFFMIIFC
LLKRRVLGPINEQVDAYIASTLDSLKNKEQQNLLLNKMNELLHSCYSVEEAYSIIQVTAK
DLFQNLNGGFAAYNTSSDELKTVCQWGQTKYLPEKFSRLSCWAMRSSSIYIIRNEKNDVI
CQHFTEIPQGWYLDFPLIVREEVIGLLHVNGHPFFPLETGLQQLIITFGENIKLALANIN
LREALRYQAIRDGLTGLFNRRYLDETLPRELKYINRDKGVLTVAMLDIDNFKKVNDEYGH
DVGDVVLKSISTVFQQAFRAGDISCRFGGEEFVIVLLGSGKEEAKSRIENICEKIKQLVI
QTQGIHLPPITLSAGIASAPEHGSKAEEILGKADEALYAAKKAGKDRVFIYKPRILKNSI
LKDPG
>A0A2T9I9T8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agona|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5I5U6V0|diguanylate cyclase|EC 2.7.7.65|Salmonella abony|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2S8DGK9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8E6BL03|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MLKELFLNLTILITFNYLFTLLFKESLSYKEDRPMFQLLKGTVCGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFAIIVAGRILINFNASAIFSIAAVGVIAILSAAVL
RGKKPDHKMAFVMLLFSNVIFTLTLLFLMPEQPAGALVYYWLISILGGMLSLYIIKHEAD
ARVLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRTSQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSHTSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTPDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A5U4C2Z7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGLTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A764NNX2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPIWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0D6FL63|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A702E6E8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y7ITF0|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSNIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V7HIT2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A747HPF6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGIWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5I6ELF1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Chester|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A611V401|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
AILLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A443VSL5|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MDKPQWVRKLRRVSSPGHVVNYCFVAVLFVSTLLIWREVMVLEGAYVTNQRNNLENVAHE
MDSLLLFNIDRMVFFRNGMQSALETPLDFEILRHAEQEYMSKRHEPIWSVALHNRRTLPV
YGVSDDFVDSQSALSRNDALTGNELMAVLELGYLLRLVNDNRGFNERMLYISRSGFFTST
ELPKSAVQAQTLYTHAIAASWFIRQSQRNNPDRGVIWQTVFDERAQNDDSVVTASIPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIASSASGNVLSLLSARER
AMLSYAFLHENQGGIRLLTRYISWQKLNNFDGMLLRIHTLQEGVRGAFGTITIALTLMWL
LFTLMLLISWQVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFERAIATTRMCERTG
RPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQMATAIAERIRIRIYSREILLCNDTSLRISASLGVSSSDDSAGFNFENLQSTADHRL
YLAKQNGRNQVCFADLL
>A0A5U2TFZ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTQGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEECGDYDFEQLQ
SQADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T6N1U1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A5U3YZW3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Y8PBT3|diguanylate cyclase|EC 2.7.7.65|Salmonella virchow|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0H4W6I4|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MVHSSVRFRLRSLILWCSLFFLFVALAASFYATYRVKRDVLIQDTLQAHRVYAEKLARVT
ENYLRSCRRLLFVSADELQAQPTLDRDAMQAMVDRLVQLSDLFNSIIVVDAKGVVLADSS
HTEGLAGQRLIHPFAKLAMAAQGPLTSQPFRSPYSGRWLVSLSQPIFGADGQTLGYIAGT
IYLHAPSIVRAILGEHSYEDGSYSYVVDSSGMLIYHPVAEREGESVHNAAEQAVRRGEHG
AMRFFNQEGVDMLGGYAPVASVGWGVIVQKPTEAALARVDRALALTLLYALPAILLAIAG
ILWLSNLIARPLRQLAAIASRMEERDVSERLRPIRGWYQEAADLRRGLLLGVSAIGQRMG
RLRQESSRDPLTGALNRRGLALALEELKTQGPPVAVIAFDIDHFKRVNDQHGHHIGDLAV
TRVSHMIEAQARGGDAVARLGGDEFLVVLPRTSLAGAAAFAERLRQAVAQARIEDCSPIT
LSIGVARYPDHGPDLDTVIKCADKALYDAKEQGRNRVRVMTAQGMRDAQQIIASAK
>A0A3T3IJQ8|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8B4RR05|diguanylate cyclase|EC 2.7.7.65|Acinetobacter junii|TrEMBL
MISNLYRSTSLHALFRKSQFTIFAITFVICSCTFATISMFTMETYAKQNLQLLSQTVIER
IQPAVVFKDKGAIDQILKDYTTEHAIRSIHVYDPQQQLLAESTKKIASTSFLQKMLDEWF
LHDPIKLMIFHHQKKVGELVLYGSSENIVHFLKTIIIGLAISMFFIVIALLWSVNLTYRQ
IMQAIKPLTHIAQLVSDQKAYNLRFPNNHIKEFQNLNNVFNELLEEIQIWNTNLQKENRQ
LSFKAHHDQLTTLPNRHFFYEELLNIFENPSYRENSALIFIDNNKFKVINDRYGHLAGDA
VLREMALRLKQSVRQEDFIARLGGDEFAIILHSIHHADHLEAIAEGLLASCKEPLDFNGE
IIHFGFSLGIAFSQYAENPEDLVVQADQAMYKAKNLIPHWFLYKPEI
>A0A8G1ME20|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MPLHSPLYSQRSLVLTLIALLGAGFLATSFLSYYASRASIRDSIVNTELPLTSDTVYSEI
QKDLVRPILISSMMSRDTFMRDWVVNGEQDAEKMTRYLNEVMTHYGAYTAFFVSNTSLTY
YHAKGVLKQVKSTEPRDAWYFRVRDMADPYEINVDPDLANKDNLTFFINYKVYDYNNRFI
GAAGVGLTVDAVIKLIDKYQQRYQRSVYFVDNFGRLVLTGAEGGPQGAHIGQKLGDLDYM
KDLVSQLPKPHSGSYEYSVQGQGHFLNVRFIPELNWYLFVDKREDGALSEIRQSLYLNLL
ICLFITLIVLLLLNRVIKRYQGKIQAQATLDSLTELPNRRGFDLLAAQAMLEARREPKPL
TAMLLDLDHFKVLNDTYGHLAGDQVLIGFARDLESCLRHSDIVCRWGGEEFIVLLKDTDG
ETGLMIAEKIRQHVEQQRYAYDGKELQLTVSIGLTTLQVDETLHTLLSRADHAMYRAKQA
GRNRTCVEMPHSSYE
>A0A1C6E0C2|diguanylate cyclase|EC 2.7.7.65|uncultured Lachnospira sp|TrEMBL
MRKKWKYFLISAALLAIIFVSIERYDNYIGQKFYQESTQGLLATYEQLDKTFMMFAQRNW
NALEDWCNYLNYCVEEQDKKEQNAEDGWGNFVNDRKNWQYSDFYVFNEDCEYWTIDGRRG
TAEHVKDAFKALYEKKGPIVSSYVASDGETKILFAVPSDPIELNNVTYTAFAVSYDNSVV
EKLIGGGVYNNKSDCYIVDSDGTVLMSLEPETQITDDFDNIFDFIQDKTQSYNEDYLERM
KKTVPTKGKGSVSFKYQKSEYYLVYQPVGIDDWSIVGIVEKSVVDSGMRMVQGTTIVLLC
MMETCIMIGVVILMKQRAKAQLQKEADERIKAEKKKEFSDQLFWGISQIVDCFAVCDLKN
NRYEYEDKRGKYLYPKRGAYDQFIKGISDQYTILTDGENAKFTNMLSAEHVRQLIKEQKD
SYCLEYCARDKSRFFIMSVIPVEWEGDTLTKIMIVSQDMGQQHELENLANTDALTGLFNK
RYFEKMMEIRDEKKKPYALFYMDLDLFKPVNDTYGHEMGDKVLKEVAKRLLKCIRSNDYA
FRIGGDEFMLILNGNLDAQICKKRIERIKKLIGEPYEFDGYTIKIGISCGSAVYPDDADC
AADIQKLADKRMYEDKKINHAQR
>A0A377RL12|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MLMTTLMCGAMSIVMFSVYRSFRREVQGLGHWAAGLLLLVCASLLFGTREVLPPALSMIA
ANAALVAGIGLSMLGTEKFFGLVPSRRAYLLILALAIAGNSWWLLARPDFSVRVAVFSLL
VFLFYARQVQLVWCHGERHFSSFFFGALMLMQAVVVLARGVSALLHGGASVNLMVAGTPA
GIYLAVANFMALLLTVGFMTVATRRLQQILERRSTHDPLTQVLNRRGFGDAYARETGNLR
RRRLPLTLLSIDLDYFKLINDRYGHAVGDQVLAHVAAVIGSALRESDCVARFGGEEFVVL
MPDMPAHNALGVAERIRALLHEPSHAGLPPCTVSIGVACQASVVEGLEQLLSRADAALYL
AKERGRDRIELDACAVTEGRTMSAAGSGTGR
>A0A1Y0WJQ0|diguanylate cyclase|EC 2.7.7.65|Pediococcus acidilactici|TrEMBL
MALNADIDNSQLGWQYSNAQFIILFYCLYIVHRKTVLLFNMGLPIYIYGLAIIRHQTQFN
ILNLLAMLLLIAIIWVVYRNSEWLIDSAWYYATQFLFGVAWWSILKGIRTMTVSQVLLLT
FEFMLMMTIVHFGNIEIRAMIKRYMKLEKDNGYDFLTGVRNRRTFNEVSNEVFEVYSNND
LPVAMAMFDIDNFKLFNDQYGHQVGDRVLKYVAQLFSDELFERKTNAQLFRVGGEEFTII
FRNRTSAEAAPIVKAIRDILVEKTFKVKDDLDVRITVSIGVTDLKKSDQSAKDFYKRVDK
YLYQAKNNFRNSMSVEGDVSSLS
>A0A381H2S8|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MTMDYSLLLIDTDRFKSINDLYGHLKGDEVLCALARTLEACARKGDLVFRWGGEEFVLLL
PRTSLEVALNLAESIRAAVAKVCIPGLPRFTVSIGVARHESNESIDELFKRVDDALYKAK
NDGRNRVLAA
>A0A381H6Q0|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MYEFDGAGGLRLFIAGMVLMVVSCLVTLQLTGITVAFRSAPLEWWFSLPVIVIYPLLFAW
VSYQTATKLAEHKRRLQVMSMRDGMTGVYNRRHWEILLRNEFDNCRRYHRDATLLIIDID
HFKSINDTWGHDVGDEAIIALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPADNAIAAMS
RVHERLNALRLPCAPQVILRISVGVAPLTTQIGHYREWLKSADMALYKAKNAGRNRTEVA
A
>A0A2X2WHX1|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MYIDSLTGCFNRKILDIVKRRDLTRSCVVLLDCNKFKAINDTWGHVAGDRALQIIANRML
SNTRTSHDLVIRTGGDEFVILLYRAQIGDAIAIAERITGQINDYAFMVDGHVVPLSVSWG
VAEVTRDLDTAIQDADNEMYKMKQVRE
>A0A0X8HAV8|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MKTDGHATPLAGTPTDSASLGSDWVNADLATLRAKFYQLYIAVEQSPAATAITDTEGRFE
YVNQRFIDVTGYTREELVGKTPAMIQSGMTPESVYRDMWQTLRSGHVWQGELLNRKKNGE
LYWEAETLTPIRNDSGEIVNFVAVKEDITKRKRQEEELKLLASVFQTGQATLITDANMRI
ERVNQAFTDITGYAAEEVVGLTPKLFKSGRHDKAFYARLWESVLETGHWQGEIWNRNKHG
EIYPLWQSITAVHDENGKVRHFIAVFHNIAERKRMESELEHQATRDHLTGAHNRRAFDAT
MRKAIRQAERSDNTFSLLLFDIDHFKAVNDQHGHETGDIILKRLAALVSQTLRSTDQLAR
WGGEEFAILLQDTPVQGGTVFAERLRQQVEETRLHGLAVTISLGIAEYHKGDSPEAILAR
ADSALYRAKRSGRNRVGIANPPA
>A0A2X2UTK1|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNDENFYKKAVAQSEPPHSPQNDHQRSGLRFARRVRLPRAVGLGWMFLPIAAVLASQQIA
GGWWLFLVGWSFVWPHLAWQLASKAIDPLSREIYNLKADAILAGVWVGVMGVNVLPSTAL
LMMMCMNLMGAGGLRLFIAGMVLMVVSCLVTLQLTGITVAFRSAPLEWWFSLPVIVIYPL
LFAWVSYQTATKLAEHKRRLQVMSMRDGMTGVYNRRHWEILLRNEFDNCRRYHRDATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPADNAI
AAMSRVHERLNALRLPCAPQVILRISVGVAPLTTQIGHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A6S6ZBG0|diguanylate cyclase|EC 2.7.7.65|Achromobacter deleyi|TrEMBL
MDPILAELSASLQAAKSVEQLTRPLLDMLGAVTGLESTYLTSIDPDADQQHVRYARNVGT
LQIPEGLSVPWSDTLCKRALDEGRMATSDVAACWPDSDAARQLGIQTYVSAPIRTDDGLL
LGTLCGASARQQAVAPQAESILRLFSSVIANFIEREQLVAELRQANMQLMAYALTDPLTG
LPNRRALYEELDRLRSRALRDGDSVLVGVVDLDGFKGINDTYGHQQGDVFLQEIARRLAM
AVRTSDMVGRLGGDEFVLIGPGPALARGDAAPGQDAERGDAQEAARSLEDRAAAATVGRY
QLGDTALPYEGASVGVVALDPRGLAAEEAVRLADARMYEIKRARKAARTIH
>A0A8G7A5Z6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYADDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A4P0TK76|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MARRRRDGGELLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGE
EFVVLLPATPLDAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFVGNEAGEAAFER
ADQALYRAKRAGRDRLEVA
>T0PJF9|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MAQSSRSIDHLLAYSMFPVWAGAILMLLIVIALAQVPAAQRVEEQRMKDHLQRVIKAVQG
DINAINAFARDWGIWDESYRFLAHPNQAYIRSNLLVDTPMRDFELNVLSFMDLQGHEIWT
RTLLPETPDTDTTLLPFFLDDLKQQLLRQSRQNGVSSLSGVRGSQWGPLIFSLQPVTDSQ
GSVKPNGYLLVTRWLDARYLSDLAERTALSLTISQPKPSDNFVSFKPLKPQMRYRLVDLG
LQRVRGEGLLLDNEGDPVLTLIVEEERYVLQGAMEGAIWTFFGMLLISIACVLMALARLR
AIVLGPVSEMVKALQKFGDKQDVSLLPLIDSSQEMALLSRKFREMAAKISLHHSALQAHS
SRMEVAAYTDPLTHASNRRYLDEWLLSRDNVTAARVLVILDLDYFKQVNDRFGHDMGDLV
LCQLAALMRNALGEEEPLIRLGGEEFLLLLTCEEAERVAARIERLRRKIAEYRFGREEVP
LRMTASLGYCSYPLHPELKDSFWNLSFKLADMALYRAKQEGRDRWRGYSGELAREQWALS
PEQIVEGEFLLCQASHLRQPA
>A0A485F5P5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MDERASKPPGLLPLSREDLEKTLRYALEIVSDGIWDWNIATNQVSRSAGWYLMLGYPPHS
LPESVETWKSIIHPEDYPRVMASFQAYLDGESPEYCEEYRCRTYSGDYLWISDRGRFVEF
DERGEPRRMIGAHHEIHQRKLVELELQQRNEELFDWNLRLEELVAERTEALHRVNQALAS
KMAEAQRLSEIDPLTELYNRRKFEQCLHHEWMRRQRHGRATALVMIDVDHFKRINDLFGH
STGDRVLVAFGRLVASELREVDVLARWGGEEFILLLPETGLEAAAALAERLRQRVRSQSF
EMGERLTASFGVGVLNDGETLDLLLCRVDDALYRAKQRRDCVACC
>A0A6N3AW40|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MSPLSIRSFTLFREEQPVRDALVLFTLTLLLHFFGAMLRLVQELSFFWPLNAVMAGIFAR
YIWLNRSYFYAICFAAMLVYDGLTSRWGMGFASFLINFSNLVFIVTLAQLILWDKRRTDS
MPGPINALSLFCYCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSAFGRFRLRQLLPAIALVLSIVLGVAVGGAGSITFPLPALIWCAIRYPLPLTCLL
TFITGISEILLVANSLIHLSPDSRMQPWQLFSTRLGIAAMLISPVIVASSVEAINNLVKQ
LALRADFDFQTRVYSRSGLSEALKRQPIAENTLLTVMVLDIDGFKQVNDRWGHECGDCML
AQFAQQVRQLVGEEGMVARIGGEEFAVAALTSSGQEARLLAEKIRQGIEAQTFTWGQSKI
QLTISMGLESQPLGAARITDLFNQLLMAADDYMIQAKNAGRNRIFTQKMA
>A0A6B8MWI2|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MDKPMWVKKLRQILSPGYVVNLCFFFVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHD
FDSLLQFNIDRMIFFRNGMQSALGTPLDFSVLRKAEEDYLAKRHDPIWSVEIHNRRTLPV
YGVADAFVDGDELLTRDNPYSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
EQPKNATQALALYSRSTSDSWFIRQTQRNNPARGIIWQTFPDDKSQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKAFLVNAIKTGQEGEYQLYDNRLNLIASSAPGNVLTPLSPPEQ
ELLSGAFAQDNRGGIRLVTRYISWEKLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMLSWWVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAATRLSERQK
RSIAVIQLDLDYFKSVNDLHGHHAGDRVLSLVASTISSHIREDDLAGRVGGEEFCIVLPN
TGLKDAKVIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSSDYNFENLQSIADHRL
YLAKQNGRNQVCAEG
>A0A8E6S2A6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 6,7:m,t:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V4T0L1|diguanylate cyclase|EC 2.7.7.65|Clostridium thermobutyricum DSM 4928|TrEMBL
MDYYRELYNNLKNEYEIYQNYTEKKIQQVINRNIKLEKDMDVLSNIVQISQYINSYIRDK
NLVSMINDMIIGVLGVKHSSIYTMKLGKLEIRASSPEACKMELTEEERKHFEEGREYIFN
SNTYLKICPSCKTKIKSSMGMPIKLRDKFIGYIIVDHTINLTEENRIFLRSISNQIAIAL
ENSILYMELSNMAKKDPLMGIYNRKYFFKKVEKLLEKEKDIDYAIVMLDLDNFKKINDTF
GHQYGDEVLKVVGRVVIKNALKTSIFARYGGEELILFVYGFKNKEEVYNQVETMRKEIQD
KEIILGDIKSNATASLGLAFSSNENRTLLDIINKADMLLYKAKHNGKNRVVCEEEFIKET
NIL
>A0A1T4ZLM5|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MEKIKVGILYSLSGTMAMSATPLLEATLMAIAEINAQGGILGYEIEPVIEDGASNISIFE
DKARKLLAIDQVATVFGCWTSTARKAVKPIFEQFNILLWYPVQYEGLESSPNIFYTGSCL
NQQIQPVISWSLKNLGKRFYLLGSDYVFPRTAHKLVKSLLKHEGGTVVGEQYFPCGDKNF
TDIVDQIKQIKPDVVFNTLNGDSNFYFYNAYYDAGIKPSDLPIMAMSISESEVQSIGKAS
VGHYACWSYFQSLNTPHNHEFVNNFKALYGQERVTSDPIEAAYFQVYLWKKSVETAKSFK
TNAVRKAAYCQTFYAPGGLVKIEPNHHLWKHCYVGRVNEIKQFEIIWKSPNLIKPLPWLG
VEELKNFPQADLVIDMLAEVSQGIQHSCLLEQNSLSLELTMRKLQQEIEERQRIEIALQE
VNKELKYMAITDSLTKLSNRYWFNECLKSLWHQNLQTKTPLALILCDIDYFKNYNDTYGH
QMGDYCLQQVAQAIKKSVRNSCDIVARYGGEEFAVILPRTTLFDASQVATRINLEVQQLE
IPHLNSLVNDYVTVSLGVASQIPLLKSSPELLISESDKALYQAKHNGKNQWCLHYV
>A0A533QLN8|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MSGGTLLVDEVVGEALVPMAGLLRLLMPTSAVGFALKGLDGRYRLANRAIEELLCRPGER
LTGRSEEELMPAAACSLLAECDRQILAGEASAWADVELACSGQNRHYSWLKMAILAPDRT
LQAIASLVEPARQQASLAIPETLRRLQEANRDLQQMVIELELVASTDRLTGAWNRRRLEE
SVHSEMERMARYGHSLCLLLIDVDRFKPINDQYGHAVGDAVLQRLTALLQAALRKVDSLS
RWGGEEFVVLCPNTARATAAAVAERLRREVATAHFATVDNVTVSIGVAECATGESWEEWF
ARADAALYRAKSEGRNQVRVAPELAGQSGSGGYVVANFVQLVWRAAYECGNEIIDRGHRQ
LFADANRLLAAMLSDQPAEQLGPIVDQLLTDVVEHFRDEEAVIGAAGFPATAEHLLLHQA
LTAEAHRLLDHYRSGTRGVGDVFQFLAYEVVTKHMLGADRLFFDYLRPEAAGRPGTATLP
GGRR
>A0A7H4NYQ4|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSKAILVDGRQKPFASWHNERLVRQDKISDVIS
KWLFPDPTVQPNLAPGENHR
>A0A1E3GUL8|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MRTLRTRITDRGSIWQILPKNQGDKLDYENLKRLCDEFPLGIILCDEQGRCLYSNQAYTN
ILGYAPGELLDLDWHTCLYSEDAVPLNAKWKQAISSRSSLQDDVRLIRADGTMIWTRLHA
AMLDIADYPFASLLMVEDISERKALEKILRQVENALFEEKERAQVTLDSIGDAVLTTDLA
GNITYLNREAERLTGWDRLKAMGKPLLRVFNIIDGGSRDTAPNPAQKAMQENQTVELAIG
CILITQDGTEVEIEDSAAPIHNRDQQVSGAVIVFHDVTKSAAMMEKTNRLAWYDHLTGLP
NMALFTELLSQSIGMAYRHNKRVAILFLDMDDFKKINDSFGHLTGDDLLKSVADRVTKCI
RVTDIVCRRSGDEFLILLGEIELPEDATLVARQILSAIAVPQRVNDNDITLAASIGISVY
PDDGLDATTLMTCADRYMYLAKQSGPNQFYYSGPPHTGKVKP
>A0A1V5FYP5|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MRSSLLRGLLFVSLWRVAELAYGIDSASLQDRLDQVERQAFENWEGAINGLDSLSFQARD
SSMAVPDDERLLWETRGLLFAQKRDESEVQQIAARLRERGQSAPEEEKARFERSALVLEA
ALQDANNNTENAVALVRQWMPKLRSECLSSSPLASCDYRLFWRSLRWLERGATRRGMLAE
AQQFAEQALKLAAQKQDSYRISQVAASLAWLYARSGDAELSQRYLAESRHAGAAADDLQL
RARNLMIEAAIAVELGENQRGRDLTLQALAVAGRAGANRLRVHILNNIADAELRLGRSEP
ALAAINEALPIARRFGDMVSERTLLSNRGVAHIRSGEIAAGVADLAEVEAMLARMGSRAE
QVTVLREYGEAFAQAGEARRALELYHRERAISAVISEENRQSALRELQAAFEAEQRQRDI
DLLASDNALKDAALATNDLQQRVWLVLVTILGLAAVAVVFAVRKLSRLRSQLHHHKLVLL
EESERDPLTRLGNRRAWERFIASVQPSQLQQCALFLIDVDHFKSINDLHGHVEGDVVLCE
VSRRLRGSLRSSDLLVRWGGEEFLVLAQSLAEDQFAPMLQRLLSAVGAEPISSGAVRRDV
SVSIGACRLQGTNADLLLPWQRALLLTDLALYAAKSSGRNRGVGIPLWTAQILDAPLAVT
NGLEQAQSRGWLQLIEQYGPQRDGAAAS
>A0A446CNG1|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MTTSLFFLMWGLATALALPLLVPFHARGLGGIKAFTAANALAVVSLLAYATSQMLPPGVY
VIVSNAAWVSALSLAYIGVRQFFGMRPHIRRAAVLGALFVLAFALMLYGQDDLRGRMLLF
SGFTCAAALATGRVIFRQRRRLQTRGVMLYLMLAIFGLAALHALRIAVYTVGGEAPASLL
EPSPWGLFFIVCGTVTVPALFLALLLLVQTSLSEQMQAALTFDSLTRAYSRRSILDELDR
ELRRCKRAGGKLAVLVLDIDHFKSINDRHGHAGGDTALRHYAQVVQRAVRTSDRFGRLGG
EEFALLMYDCDPAHALVQAQRVCDALRDAPLFLHGVEVPMTTSGGLAVYQPGDTADGILA
RADAALYRAKQQGRDRVELAWAGRAPGRAQPAGPAEAAGAAAAGQGVESTA
>A0A1E3GWA6|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MRNHPNFKVFFSAVLLTSRYSEHMSKHVEKWFFNRTFIVFVMVCLWFIGALSLRFFYHQQ
VSGYQSSIHSQISQRVSMSSALQAELIDKEFSFLAANLKQLGSLSVESPKQVSAFAMRLK
NLNPSIWHITIADSKGEVTFSTRVGYQPPISLRDYFAEHLKSNQINFFISSPRQSVIQES
ALYIAMSYPIRNPEGEFLGVAVTTLTSEALTAQLGKITNNKNISAVLTDQFGKLIWSSNL
ADGLQKGDVYSLCKDNKYQTSTDLGIYRIKLDDNAQCDFQFLDKWGMYSIVAENLTPSNQ
LIQRYQNQMVKRNIIILLAFSLLLMILGYQLLKQIESRQLLAVLNQRNKAIIDAMPDLLL
TMRIDGTIIDYEVEESFPLLMSADKLNGLNISEVLEPELVEKKLALMASTVLTGEPATLE
YPLMVEGKEYYFLERLTALDDKHVLAFIIDITSRREAESKLEWQAYHDGLTGLANRLMFF
EFINKLIQDYRRNKREFTILFIDLNGFKAINDNYGHHAGDEILKHTANHLLSILRQTDTL
ARLGGDEFAVLLPETSPAQAQRVIETIADAIQKPLVYLGNRLCVTASIGMASCPQDATSA
DELINTADKRMYEVKLTDR
>A0A8E2TB23|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9AIL7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTDFGREIRATVLQ
RTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVDDVWGIGR
RISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPTKQEIIC
SRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSAS
VKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPG
SEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRVK
>A0A2N9LWI7|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MNSLIRTAEAPSHRAFPSGPQDVAHALLASDLVAFVLVDSGNIIAASPALREMLGGTPPY
HHVDGRTLLSIVAEVDGAGVAAFCDGALQGNGRAEHRCHLMRADGAPLPVLLSAAPVPVE
GARQLLIVVTDLSTWVGAAAEADAVLSFTAFDRATGFPTRALLLDRARIALAAARRYRRR
AALLRIDMDRLKALLQSLSPEGADEVQSTVAETLRNCVRDCDTTARLGPGEFAILLPEIG
QREDAGITAARVVQAIEALFERNEARYRVSAHIGVAVYPTDGTNPERLLNGAELAVHSAK
SSKGGGFALAEATSAELTAIKPLEFLDRYRVGIPEIDSEHRNLVDRMNALAHDLKSGADP
TTLEYDVRAMVELLRGHFASEASLLAPSPYDGTADVKTRNLRFLEELHCILLHVNSQSIA
LAIRHLYDFLIPHLVHLDQRRVS
>A0A2S8DR40|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNTQLLRTALHDPLTGLANRAAFRSGINTLGNDSNLLIVFYVQIMPDDLVMQLHRF
>A0A2P9H7X5|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MCEHRRMNSSFFRRLCTPGAISPGVVEAVSILAMVALFGLERATGAQIWLHVLYMFPLVA
LAIHCGPPGLVALGFLMTVGFQIVTIFANESSALARSVNSLVALAWPILVVLLARFARAS
YFDIADLANQDPLTGLPSRRQFESIIEREIARQKRYGGVFSLAIMGFDNFKALNESRGYR
VGDEALKVLAKLLRENTRRSDSIARLSGDEFAILLPNTRRADCTSLCNKLSIMIANRMSD
EGVATSASVGGATFENAPESTSDALQKADRAMSAIKADRKGYAAAVLTLAARRRRRQAG
>A0A212KFS4|diguanylate cyclase|EC 2.7.7.65|uncultured delta proteobacterium|TrEMBL
MAQSAYSNITALLLEQDIFHSLFDISRIVDAESGKIQDLESGVVLETRTSCNDVFGTDSR
CKNCTSIRAHYSNESVVKLEYVNGSVLLILSVPLQVCGKRLVAELVKDITKSMTVDLKDS
LFSGEVPAIIDKLNKISTTDQLTGLQNRRYLDDRLPLALANCRAMCAPVSLVMLDIDNFK
QINDTYGHQHGDVIIREIAAILLSYIRRNSDFAVRYGGEEMLLCFPGVSLADCLSIAGRI
HKQIQAAVFAHHDRAVSVTVSMGVGESQTDGTYDKDGLIAIADKRLYDAKKSGRNRIVSS
DAL
>A0A3D1C2I8|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDQFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8G1NSM9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRXEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGXVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEKFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A377U0K0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQNRRLQYDAYHDSLTGMPNRLSFWQRLQEIVNQVRPYKGCAVVMLFDLDSFKDVNDTLG
HDAGDKLLQDLASRLSFFPQNLRDAVSPWR
>A0A377TVB9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAVGGAGSITFPLPALIWCAVRYPLPLTCLLTFLTGIGEILLVANSLIHFSPDARMQPWQ
LFSTRLGIAAMLISPVIVASSVEAINTLVKQLALRADFDFQTRVYSRSGLSEALKRQTLP
ADKLLTVMVLDIDGFKRVNDALGHEGGDCVLTQFAQQVRQLVGEQGMVARIGGEEFAVAA
VVDSAQQGYLLAEKIRHGVESQPFGLARTRST
>A0A377V1C9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFTSARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFFDRR
>A0A2H5WK07|diguanylate cyclase|EC 2.7.7.65|bacterium HR13|TrEMBL
MVRNVMLKRDAGMKGVERYEVRIKRKDGKIRWVQISSETIFYKGSPAGIGVVVDITERKI
NEKKLRKLVMYDRLTQIYNRYALEEFLSKELLRAKRYKLPFSIVFFDIDDFKHINDTYGH
KMGDMVLKRLARLVKVNIRRADIFGRWGGEEFLIILPLVQDPPAFAEKLRKMVESTVFDK
GIKVTISLGVTTYREGDTMDTILRRVDAGLYRAKREGKNRYYVV
>A0A4P0Y2Y4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATF
>A0A445N216|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfobacterium sp|TrEMBL
MAAHVDEKEIKESVKMELSRALEECKNRLEFFQTAFNALNILIKEFSLDLREINADGFMD
ELDRLAKKILSDEKAKKLPAHFEKQKKLIFSYIERLKKYLYDRENELKDIIDLLTKAMAT
LDTDNQVFNQEIYQQSERIEKITLLDDIKKVKSALQHEVARAREAVKNKQKSDSQRMEML
SRQVSSLNTELEKARLESQTDGLTGVYNRMAFDRYIKNLEEKNNITNAPFSLLLIDIDNF
KQINDTYGHQIGDRVILALIQKCKEITRRDDHVSRLGGDEFAIIMEGASFRNASKKAKKL
TKEIANTRYAVATGYDSFEVSFTISIGVSTFRKGDTVATITERADKALYAAKSAGKSRVV
SEKELR
>A0A2Z2NSM1|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MSSMSVNENARMAAVLGLDLLDTEPDAEFDSIVQAASALCDMPMCLIALLDEHRYWFKAA
IGMSGMTEVAKEISFCKLSIDCQGLLQIPDCTQDVRSADNPLVLGAPGLRFYAGIALSLS
DGTRVGTLCILDTKPGALSDMQKQVLTHLAQAASYALESRRVALTQIASESTFRTLCAVS
PLGIFSTDIHGFCTYTNERFQALFGLSEHESLGSGWRQAVHPDDRNQGFAAWDSGIGSRV
EVVRDFRVCHMDGRVLTVTGTLRPVFTADNKLISFVGSVEDITERRNHQAQMERSLTFMR
QTGALAGVGGWELNLSTSQAFWSDQTCIIHGVDTEYQPDIQAGLDFFLPEARDILVNALQ
ALTADGDTLDEELRLRRADGRIIWVRVRGEAVLREGEVVRLRGAIQDIDNEVRQRIALKN
AHDRISIATQSGDIGVWEWDVESGHIDWTPQMYKLYGVEPDATSLSLDWWSQLIHPDDQQ
VAEIMLSGLMEGEGDLDTEFRVVRPDGSVRHLRSCAHIRRDVNGRALTLLGVNWDVTSLR
QLSMELAEQHELLHVTLQSIEDAVITADTAGLIVWLNPAAELLTGWGCGDALGKPLEDIY
KVCDEQSGLPLKNPVTECLVRDQPLNCGRDAVLLARDGSRFGIEESAAPIRDSQGQLFGV
VLIFRDVTEQRRLRAEMNFRATHDELTQIFNRSEFESRLRKTLNSLRDNTEPCHALMFID
LDEFKLVNDACGHPVGDHLLRQIAGLLGQTLRAEDTLARLGGDEFGVILNNCSVTHAQQI
AQQICHRMDDFRFAHGIRRFRVGASIGLVPLNDRWASPASIMQAADTSCYAAKEAGRNRV
HLWLESDQNMRNRRGDMQWAARLEQSLDENRFELYAQKLVSLTDDCVGLSAEVLIRLSSE
GGRVILPGAFLPAAERFHLATRIDRWVLQKSIQTLAELPSLKDVRRLWINLSGQSVGDRE
FHRDAIEMLTQAGSEICECICLEITETAVVININDAADFILSLRALNVKTALDDFGAGAS
SFSYLRNLPVDALKIDGQFIGNLVENPLNAAAVRCFVDVAEVVGLRTVAEYVQTPEALAY
VKELGVDFAQGFLMHEPEPIGQLLRRSLGAQSESNEVGGALV
>A0A3M2RBT6|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MLYRLKNDFRLSIVTLLSGSAILGVTPFAIMRFLDGNLLAGFIDLGILVALAGSLVYAWR
THDTYRSGIFVAIASCSGAVAVGMLVGEVALFWLYPCLVTTFFLAPSRIAAIVNLASVLA
MMTVESAFTSSVQMWTFFASTTIVSACSYVFAMRNKEQRDRLEQLATIDPLTGVKNRRSM
DQELDLAAANAERTGLSYALVILDIDYFKKINDEYGHGVGDNVLRDLVGLIEENTRRTDQ
LFRFGGEEFVVLFPGVDETNLKTVVTNLQQGVRKSLKGPGGPVTSSFGVALLRHGESVAS
WLSRADHALYRAKESGRDRVVYGDDF
>A0A212L640|diguanylate cyclase|EC 2.7.7.65|uncultured Pleomorphomonas sp|TrEMBL
MNLLAFLRFRKADLLRRLANLLPILFTVVLLIFAENSALEAYRTFQRIEASNASEAMQAG
RDIGDQAKLVEMSRRKLGNRLILGFTAQDAGDIRDALQRLLATIERARPSFIMPGDAALI
AQIDSIAELASGLGVAFASVGPDDTAVLNALDGDLRRLSEKFRLLQENMTEQGTRYIALQ
GETLSASYSAMLKLSIALVGAIVSMLALLVLNRRATWQANYRADHDVTTGVLNRRAFERW
IEGIHFDPQASKAVMVFDLDNFKEVNDELGHMAGDHVLKAFVSNLVASFGQDALVVRWGG
DEFVVVVSTEGFVEAGAVTLLRASFARLQSIVRFGDTDIDIRCSGGAAVWPSDSRDFHEV
LQLADLALYKAKSRGKSRLQFYDADILNERHKVLALRERLRAALRDGELSLYWQPQVDVE
RGYIPSAEALIRWTDRESGELIPPGEFIPAAEASDLIIEIDNFVIEEAVRTAARWATIWQ
YPPIVAVNVSAVHFQRREFVGQVRDILRRHNVSPDQLELEITEGVILGNNIEVTRNLKGL
EALGVHIALDDFGTGYSNIAYLSQLKPDRLKIDQTFIASLSGSHQMESLVSAIIGIGKAI
NCEVVAEGVETADQLDLVRRLGCCLVQGYHFARPMPDAEFQAWRDANYPDAAASVKHLRR
LGDRLASAIGGDAGRGRDRETP
>A0A6B8NHM0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MTEDDFKKSTANLKKAVPLMMQNHVAATPANYALWYTYVENAIPQMNRELETILENYGIC
PPAAGEQLYNNYVAARAETDIKDLRANIEVLVGQVASSMTDTLADTSHFSKVIDKSFENL
EKVDDEAMSIDEVMKVIRQLVAESKEIRHSTNFLNNQLETATEEIQRLKTQLAEVQQDAL
FDGLTSLYNRRSFDNDLDTLCRSEQKICLILADIDHFKSYNDTYGHLFGDAVIKGIAKRL
QISSRDGIHAYRFGGEEFALIMPNKQLRIARQFAESLRRSVEKLSIKDRRSGKQVGNITA
SFGVAELQPGEMPNSIIERADKLLYEAKQLGRNRVMPL
>A0A385XWG9|diguanylate cyclase|EC 2.7.7.65|Dickeya dianthicola|TrEMBL
MHLNLALFKNGSTGLNSLNVFMATLVGCNIGAHARLSDLDLSVFWPVNIIIAALFYRCRY
LNTPWYYAVSYAAMILQDSLFYGWGVSAFTINSANIAFIVVLTQLLNWPGFLARRETDMI
SSLYLFAACMIAALACGIVGALAQQPWPRFPAAVFRSNFLNWFSDQFYTAVLFLPLLLTL
SSQIPLRIPALRLPDMLPLLLLLLSICVAPLLGPVAILAFPLPALTWCAIVYPLWLIRLI
TLCIGSAELILAAEHVYALYGSQDPLFMHQIIIARIGIAATIFSPLMMATNARTIRQLNA
RLLQQASHDFLTETLSRYGFTEALTAQGQSAKSLQDTVNIMLIDIDHFKNINDSFGHDCG
DEILRQVATVIKQTVPTPGLVSRIGGEEFAVVCFNHSPSAFYRLADRLRQTIQQAAFMFN
QQPVPVTVSIGIAHAPTPGKYLVDTVHQLFPLADKNLYTAKREGRNRTIQ
>A0A4U9I552|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MLSMLRSTDMLARLGGDEFGLLLPDCNTESARYIAGRIIDAINDYHFMWEGRLHRIGASA
GITQIDERNNQASEVMSQADIACYSSKNNGRGVVTVYEPQQERTLEAGTISLDEQWHMIK
DNHLLMIARSVASPRIPESSTFWMLALRLWTNDGEMLEEQAFRAGLAEPELIHALDRRIL
QEFFRNFATPLTSKGTGVALPLSTAGLASATLVDELLEMLRASPLQPRLLHLVVNVSVLA
LEDEHTRNNLDKLRQAGCRIILSHVAAIWRCSTT
>A0A6B8N846|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MPPFFVLIVAIFISTLPLPAMSACNIQTDSDYLYSHTNAKQKAMLTFYYDSLCKPGQVDL
SHIELPPNASASEQALYYFGLKNLRKYEGLQTPRIPDLLSLGDDSRIEWVSAEATLNKAI
HLIESDLLLEGEFLLHEVVPIARDIGYKRLLGRTYRWLGNVKIQRSNLKSSLSYYKTAYE
VMTEIGDNFQTTMTLNNIATVYMQSEEWKRANKYIKRALDLYQKHGYDNSLFEAIMYSNA
SAIYFALGKEERSEQYMLKALKEADKTGSNKIKFSTLSNMSQRYSDVGNSQEALKLARKC
IEESQVLDTKSNITLATCYEAYAEASFVARDYQKSIDYAKQVIEVLHTSESNEVVWEIQT
LETLVKAYEAQGDYQQALAYMKQQSQVRQNFYRQTYDDEILSEKNALERQLNKREIELLE
AQNELQQTKLRSQRTREILFITLFFALAYLVIRRLWKMKRITKELESQNTTDPLTGLANR
RYIENWLSQSDNVQQHKSYALSVIDIDHFKQFNDTHGHDVGDTVLKATANQLKNNTRSHD
IIARWGGEEFVMIIPIDNVHTVEETLERLRKSVESHKIHIDEDSLAVTISVGTQLCHYQD
IETDWDRVFRKADKALYQAKQSGRNKCITFHYQD
>A0A1C3JLN9|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MLPQRSAVQFILTKVLACYLAVTGFVLCVFITWSYQQYQENRQHVVQQLRSSVETVIEQT
PDNNDQLLASLTLGTQFFSRDFASVESFALLDEDGSIVFSWPNQAQLDATDSSLFQLLAI
QNSSFTLALAFPKWPLYQVVINNLPTAMGILLLQFVLLLAVLAVVIKRGVRSGFEGFMRE
LSLVCLERPTPLQAHSFLGQFGEYRQILDGINRVILSLAKSREEFSNINKSLESHIKAKT
AALEERNQELVDLNQQLSVIANTDALTQVYNRTRFDVLFLEYVMLARRRVTPLSLLLVDL
DDFKKVNDRFGHQIGDLVLKHAAQVIQKEVGEEGVVARWGGEEFAVLLPYFDLLSAERKA
ESLRAVLAEAHFEEQSIQVTTSIGVAQLSSIETGPELLKRADDALYDAKGSGRNRVIIAY
VEENHAQLDSDSLMEGEFIEVFDVEPVPIQDEPKASQKHSS
>I2B7Y2|diguanylate cyclase|EC 2.7.7.65|Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74)|TrEMBL
MSDRSIRQILGRFKNPLRVVHCCFSAVLVLSLMLAWRVAVVLEQAYVAEQVSSLEEVASA
LDRQFQHSVDNLLFYRNTMHYALQSPSSTDKTRLAIEQFAERRSAPDWSVRLAQRRGLPV
YGTSDDFVTRHPPLSRDIPELNNELTAALELSYILQLADYSQDFQRRIFYVSRAGYYLAT
TPVPSGNRSEYLFGKILNAPWFEGNKEHINRARAVVWTDSVYPLHGVAASVPLDLNHYWY
GVLGIDFSLDAIHAFLLDNIQDKNEGTVLLYNRAFRQIASSAFFPPQAPWFSAGQIARLQ
QAMDGNLMEGSLRMGTRFVTWARLNSYDGVLVRVHTLHEGLRGGLGSISRILLMLGILCS
LVLLLSWYVMLRLVKSMMKLQGALSWRANFDALTRLYNRGAFYDLANRQMEICRNQHQPL
SVIQMDLDHFKWINDTYGHNTGDKVLAHTGAMILSALRSADISGRVGGEEFCILLPGATL
ADARMVAERIRQRLRNKALLIDAKTTIHFTASFGVSCSTELESADFTQLQIRADERLYYA
KVHGRDQVCAGEMPPTNNGD
>A0A1C3JPE6|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MLISFLRRPNNLSQKMIRVIFSIYLAVTLLITSVQFLSEYLKTQDAIVSELEQLEATVRG
PISTSLWQYDQKQLDELASGLIQMPIIEGVDIVDQNEQSILSKRFYDPDAIPVSVFDSTT
QLSWTLNGESIGLGSLKLYSSSDVVFERVWFGFALIATTAIIKMTILFWLFIWAFDRFLA
APLKELMSQVDEVQLSQNLSKRIHLANNEGNELNQLQGHMNRMLSAMSIDRQNLLEDEQA
KRDWLEAAVAKRTEDLQILNKKLKYLATRDSLTDVLNRGSFFEAAQQRLVLSQQQTSTAS
FILLDLDFFKRINDTYGHFIGDKVLIQFTQILQSFLKESDLLGRVGGEEFAIFLPDTKLD
AAFQLADEIRQAVSKTTLEIEGKTVTYTVSLGVESSEPDDQLIDALFKRADLKLYGAKDK
GRDRVER
>A0A1C3JTN0|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MKNLLFLLKLRYFGFSICFLGLSMQLSRYYDGLKWLMCSIALLYGTSIYAAVSMHDYFAD
VWTSHDGLPHNSVNAIAQTEDGYLWFATWEGVARYNGKSFKLFSRDPETGLIDAAVRALA
PANGNQLWVGGGRGGITVREHYSWSQQEPAKSLVNDILLDDDSNLWLAVEGEGVYYRQKE
GENTYSEDRLVLNVSTAHLTQTRSGLIYAATRSGLYRVSSEGAQKLQIPDIPKNVRVYYV
SVDHRDHVLIGTTNGAWRYDGKQFIELLPDLRTSTITVVEEDDEGSIWLGSIDKGLARIT
LRGVDFIDTSSGLPNNRVISWFQDSEGSIWVGTNGGVMRLREAPFRNYSALEGLEGNFVR
TLLNIPGDRFLVGSSEGLNLIEDGKVLVASEQPAARQSMLSLANISDQSVLVGTQRNGVY
RWKSGLMTPLYNKDNGLPDNEVRALLEDSKGRVWIGTVNGLVVFEQDGTRTVFDEHSSNL
PDNYIIALSEDRRGRIWIGTAEGVAVYDRRNRILPIDISIFEQAQYVFGFYIEPGFVWMA
TDRGLLRYDTIANELTGVGKSEGLPIDKLFQVVYDRMGSFWLTSNRGIWKISYVEAHRAA
SGEIAAINFEHFGDEDGMGSSQANGGSTPAAVSAKRGMLGFATAGGVSFILPTTLKQLYQ
YSLPIVIEDVEVDGVSINPQRDYSLQPGSNRIRINFAGLSYIMPERLQYQTKLVGFDDDW
NYQGSQTVAEYTNLPPGHYEFHVSVRYPYGEWHESKTKYEFELQPLVWQRRDVQALLLIA
LVAGLTLLMYWRVYALKKRQRDMAMQIHTKTEALREQAERFERLSKEDVLTGLYNRRAFD
EKVRRDFMLSIQGLGKLNLAILDIDHFKQVNDRFSHIVGDEVIKLMAKFLKESVSAPNVV
ARWGGEEFTLLIHGTEEQALALCNGLLEGVAKLHCPQLNDEFHLTVSIGLANALGCQDYQ
SLLKRADHALYQAKNSGRNRIEQYHEFRR
>A0A2H6FV61|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MKILKKRRLRWALIGASLSFLGPLGEWMVLKLFSEATTDSLLLTYFYTELVTLISFGLFG
YLLGLNAEKIEVLALHDKLTGLYNRHYLIEHLEQLLAMHKRYKRKFSLIMIDLDHFKRVN
DFYGHVTGDLVLKAVAECVRQHCRESDVLARYGGEEFIIICPDSNIQESCRLAERMRESV
EQLTSESLGFPGPQTISVGVYGLSSDEELSIDQLFSRVDKALYRAKEEGRNKVVISNQEQ
MAK
>A0A8F9YEX1|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. DSM 110486|TrEMBL
MKRWSVPEPGAAPGLVDVARKFATTLTDTKGVTLPPAELERLLLSFAQEVTEFATPAYEA
AVLRFTTLFSTAPIGIALADPSGVIMEVNLALAKLLGSTQDRLRGKHLADLAATEHGATR
IRAGLERLTTTDIGKVIERGIRLDHSEDGGLTTNVTLAWLPGDRPDTHFPVLMAADADDL
HLLGERLMHQNVHDPLTGLPNSQAFTTRVEAALAAPRTEQIALVYLDLDGFKVINDGLGA
GVGDEVLKEVASKLSAVFTGHHDGYVARLSGDGFAVLLRGEDLTRQHVVNLVDRALEDLN
EPVYLGGHGIGVSASVGIVVGACRDGGHIELRRAAELALHRAKEHGKAKWMLFDPDEDAR
DRSRYQLGAVIAGALENGEFSLIYQPTVKLAKPDEIAAVNAGLRWNHPEKGELDSEDFYP
LAQTTGMTVPLGKWLLAESLAATARWRERFGDAAPDVCIRLPKRLAADDELVMLVKEQLD
RHDLPARALRLCTDRESMFDDNGEVHDSFTVLADLGAQLVLTISGSADLELIPRHSLPIR
HVILSGPVVDALADGAAETDVRHLRQLVERGKELKLRIGAEGVRSAEHAARLRELGVLAA
RGSFVADSATGDEVDEMIERHAG
>A0A8G0C996|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLKHVRVIVPLLVLLFSLLLTVFVVYTAYSLQLRHNRTLLENLADRQTMALQQFVDSDIH
FIGSVANFFRSSTSDDWVRFHTFAEETLKGSQSLIALQWLAKVEPPQADAFTARMQQRFP
EFALYTVPNTGEIKYGLDSGDQAKYVLSDIYPLNYDNRKLLGFYSERERFTRILADIVVN
RRPNVSDKVRLLQDGIDKSIVKDGILVYHPVFSSEDDRSLLGVMVGVVRLSTYFEKLVQI
SAMEQDLDMRVIDTGFDSEDGPVLYQSPMWRADEALKIERKLVLPNRDWVLEFELHQPIN
HSEEWALLGLGLGGVIISLLLSYIMRMQLEEKQRLTDMIEERTAELRYLVEHDSLTHIYN
RHFFSQHLCKMLDEKQSFTLISFDIDRFKQINDSYGHLAGDYALTHVVDVVKKELVESDI
FARFGGDEFAILSSVTDETALYTYLERIRKVVEAEPVMLNAETPLTLTISIGASINCEYS
EPEILQSVDDQLYLSKSKGRNRVSIAQQCSKVESNYAFNSGRMFDFM
>A0A655U7I3|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLKHVRVIVPLLVLLFSLLLTVFVVYTAYSLQLRHNRTLLENLADRQTMALQQFVDGDIH
FIGSAXXXXXXXPNFFRSSTSDDWVRFHTFAEETLKGSQSLIALQWLVKVEPPQAETFTA
RMQQRFPEFTLYTVPKTGEIKYGFGTDDQAKYVLSDIYPLNYDNRKLLGFYSERERFKRI
LADIVVNRRPNVSDKVRLLQDGIDKSIVKDGMLVYHPVFSSEDDRSLLGVMVGVVRLSTY
FEKLVQISVMEQDLDMRVIDTGFDSEDSPVLYQSPMWRADDEPKIERKLVLPNRDWVLEF
ELHQPINHSEEWVLLGLGLGGVIISLLLSYIMRMQLEEKQRLTDMIEERTAELRYLVEHD
SLTNIYNRRFFSQHLCKMLDEKQSFTLISFDIDRFKQINDSYGHLAGDYALTHVVDVVKK
ELVESDIFARFGGDEFAILSSVTDETALYTYLERIRKVVEAEPVMLNAETPLTLTISIGA
SINCEYSEPEILQSVDDQLYLSKSKGRNRVSIAQQCSKVESNYAFNSGRMFDFM
>A0A0E4G6F5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDSFAGNQLKEMTEMRFARKQHIVLISSGVATAIFLGFALYYYFNHQPLSSGLLLLSGIV
TLLNMISLNRHRELHTQADLILSLILLTYALALVSNAQHELSHLLWLYPLITTLVMINPF
RLGLVYSAAICLAMTASILFNPAQSGSYPIAQTYFLVSLFALTIICNTASFFFSKAINYI
HTLYQEGIEELAYLDPLTGLANRWSFETWATEKLKEQQSSNTITALVFLDIDNFKRINDS
YGHDVGDQVLKHFAHRLRNNIRNKDRATNQHDYSIARFAGDEFVLLLYGVRNLRDLDNIL
NRICNLFVDRYPETDMLNNLTVSIGAAIYPKDAITLPELTRCADKAMYAAKHGGKNQYRY
YHDAAFPPAVETVLGSQPVEAPNVTPLKKAH
>A0A2H6ARE9|diguanylate cyclase|EC 2.7.7.65|bacterium HR38|TrEMBL
MGYAALTWALLKIPGEKPRLSLLLVPLALLGLASALKPELGIDRIYTVWDALLLLLLLPR
LEPLFRERLLGGRGLWGVGLLLFLVADMAYAFLEAEGTYPTGHPVHLLWTLGYFLLALGV
MEEASGKASFPGQALALGGLFLMPVLLLNDPTPWGVRIIALYGGLVGGLGLLYANHLEWR
RTEEKRLRWTRFLEELARLSPRVTQTLSPEAVLVGALEATRHLLPQAVGLEVRGRRGLVG
ERTPHSLAIPLNGDTAYLYLQSPLEESVPPGFLSLLGERIKQVLRQVEWGTLALTDPLTG
LLNRRGLEAELPKLLALARRYQAPISVVMLDIDRFKRVNDTYGHPVGDEVLKLLGRILQA
SVRREDLAVRYGGEEFLLFLYGADRLAAKEVVERIRYRFRHQRVDPIPYPLTLSAGIAGG
EVPESEAQLEDWVLKADYALLRAKETGRDRVTMA
>A0A655XFD8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNTFKSINDQYGHEVGDKVLKQLAQRIEAVWRGRSYRIGGDEFILIGECSAKRLEHVVAQ
CERFMFVDAERDVSFEVSVAIGXXXXXXXVLLRIVSGPNHSMR
>A0A655YZZ9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDWDSLLSATSIYSFGEHFQVAIRGLDSRGSEGEVFFGEPQVFEHAFAQENVYFPYGSWR
IAVAEKQDLLQQLSWYSRNAVRLLGYSVLLVLMAGFGVIMRLYQVAEERALHDPLTHLPN
RRYFIYTIEHYFENAKRSHSEGNFALLNIDIDRFKSINDSHGHSAGDKVLVACAERIKSS
LRVSDLVARIGGDEFLVLIPRIHREQDVLKVSDNILKRISETPIVYDDKLIHVRVSIGYA
LYDQSFATPDEMFKLADERMYTAKRRQNPLYRF
>A0A8B3K9D1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>C1DFY2|diguanylate cyclase|EC 2.7.7.65|Azotobacter vinelandii (strain DJ / ATCC BAA-1303)|TrEMBL
MPGISPEQQAAEWKLLLGQFPAPVVAQIRELATTHQSELPGYFYEQMLQDEQAMLFLTHE
QVKSRLHGTLRQWIVSVFSMSDDDAALQALIAQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFVLLRQRPLDPEHKLFGQRLISETVDLAMEIMSRAFSDAYDRNSRSEEGYRLFSVAQN
IGIEQERQRSALLDWENHLMFDLAVGQLATQLPRLSNSEFGLWFRHKGAHAFQGSRETEL
ILEGMRQIDEVLLPLFGQPAAGADADQRLQNLRLLREQTKGIIFHLDNLFEQANVLESGR
DVLTHMLNRKFLPVILAKEVAYARQNERSFAVLAVDIDRFKHINDEFGHEAGDVVLQQLA
SLLSNHCRGGDYVFRMGGEEFLVLLVDVTQAHALGVAEKLRQQAAQERFRLPGEQDLQLT
VSIGVALHDGHPDYQHLLRQADRALYEAKHGGRNQVVLARKLDG
>A0A7Z1I8K1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQKNELNPKE
IYQLADNALYEAKETGRNKVVVKEAEILINRKDDE
>A0A8G1GYB5|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MNWPALVLFSCTIFTLALALLTARRNAFPAKFYYVGMLLSSAWWSGAAGMENWQTAPADK
ILWAKLAWLGIVTVPCYWTLFVWAYVKGDDRRPTWFGQLALWLMPLLTCLIAFTNDQHHW
LYVSTLPVSDAPGAAIRYEHGPWFYLCALYLYGYMTLSMLVIINALARANALYRQHYLGL
AIAMAIPWLANAAHLTGLVTLFDFDPTPFSFLIMGGIFYWLITHRQWFDLLPIAHDVLFD
AIPDAVLVINDQQQIARLNHAARALPNMPANAIGLPLKLLPSFDNLLPTLWDRLLPVEFE
LQLGDAYFDLRSVTIYYLQQPIGLLLVLRNITHHKHNQLALQQALISLEAQLESNAQLQQ
QLHQAAILDPLTNLHNRRFLDEVTPNLLSHSTQQQQTISLVMIDLDHFKTINDHYGHSAG
DEVLRHMAQLLRRYSRQTDLLFRLGGEEFLVIFPDTSATQALRLTEVWREQLLAQPALVH
GTPMPVTFSAGIVEVAYASNTFDTAIAYADMALYRAKDAGRNRSELASPKHKISIEPLST
TAMFD
>A0A5W8MIP2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hofit|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7Z1D5B9|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQQRLTEESDILNAL
ENHQFAIWLQPQVEMNSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A7W3A7A5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00901|TrEMBL
MQRDTYFVKRSFLQWLHNRSNPGLIVNICFLVVLIFSTLLTWREVVVLEGAYVSSQRNHL
ETVASALDRQLQFSVDKLLFFRKSMGEALQTPLGFDVLQMAVARFKTVRNTPSWQLIVDK
DRTLPVNGVSDEFVSKTTLLNRDDEHISHEISAALEVGYLLRLASSSTQKEERAMYISRA
GLWVATNTPVNDDEIISRYYHFVTRPWFTQQSGRANRARAVRWFFSSTTSTAPADAPTIT
ASVPVYFNNYWYGVVALDFSVATMKRLLKDAVADHTEGEYQLYDTRLNLIASSEVSASKI
NLFDDVERAQIASAIASDTEGGLRLGSRFVSWERLDHFNGVVLRVHTLDEGVRGDFGSIS
IVLALLWALFTAMLLISWLVIRRMVRNMYTLQNSLQWQAWHDPLTRLNNRGALFERAKQL
AETCQQQSLPFSVIQIDLDHFKNINDLFGHQAGDKVLSHAAGLIATGLRTSDVAGRVGGE
VFCVVLPGIALPEASAVAERIRSRIDSKEILVKKNTTIRISASFGVSCAHEKGNYNFEQL
QSIADTRLYQAKQYGRNRVVWRDRDKE
>A0A378JPF3|diguanylate cyclase|EC 2.7.7.65|Legionella beliardensis|TrEMBL
MNTLFIPTTMIILGVLFLLKGGHLIQRLLKHTKIYQHYWLAYLCLIGFFILGYSGCILYG
IYIDPHCLNYFYATIFLLGGFYIYLSCQLMTKTIKKIESMDELTSRFEALEHRIKHDGLT
GCNTRDHLFDVLNTRFQAIKRTNKTLVILFIDMDNFKLVNDCYGHDAGDLVLKNFGQLLK
QRLRKGDIVARYGGDEFILLMENVSIDEACRIAKDIIELTQQLLSNEHITISCSIGISQL
HAHSSSIFEVIKEADRACYAAKQKATPDSICIYDINNSP
>A0A378K1E6|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MNNTWHQTATGNRSISNYLRLSRTLLNVIFIIALSLLLIINIISYNQVKNLLLAINWVSQ
SYEIIQTIDTCLYEVVSIESRQRFYLIRDSNNQHMVDVDEMKSALKLNLDKLEKLTRNNL
EQNKRTNRFTDLIERRLNLLNQIVQLKAIGKFNTHENYDLLNQSQDMSNQVKSLGQEIKS
VELVLLSERKASAVRRADRSSFTLISGGITSILFLLIAFILANSELSSREKTELQNQNTQ
TQLKKIIESTSDMIAAFDKEHRFITFNEAYQREFKRLFDKYISINLSLEKALVDIPENKK
ELAEIWKNSLQNNEENKTIELNTEHEKIVYEMSSKLIQNGDNEINGVVHSVRNITKRVQE
HTELQESYQKLANGMKELQEKNEQITLLVEMSDIMLACSSQQELSDVLSKYSQRLLRFSS
GYLFIMHPSKNYLEKTTSWGDPQPHELTFTPEQCWAIRRGRVHHVDSSHIELLCGHVSFS
LEQQDLSLLCVPLMAQNDIYGLLYLEVNLKQLPLFDENQRLLITAFAELTALALANVRLG
ESLRYQSIRDPLTGLYNRRYLEDFLFKQLHQAERTKASFAILMLDLDHFKKINDTFGHEA
GDFVLKEIGQILNNDIRLGDVATRYGGEEFVLLLFDVDANAAKTRADNLRSAISKLQVKY
GAQYVGQVTASIGISIYPDDAKSPDELIEAADKALYQAKNKGRNMVLLFSEISS
>A0A806TNG1|diguanylate cyclase|EC 2.7.7.65|Priestia megaterium Q3|TrEMBL
MYSEGVFQFYFMNMPQPVILIQQEKHQLYYKECNKAAQQFFDKMEDKIIIKEENQLFYTL
CEKAIATKEPIQYQYIQLFQPDRHAYEVTFTPLFNQATAPSHVLVMAQEIHYKKTQEEST
RLLDAFLENTVDAILIADCDEKVLTVNGAFEKLFQWRKEEVIGKRRQEMNIVSKKEEQEN
LKLIEELKNGKTLSPYETVRYTKSGESVCVSVSCSPIYDYQNQLVAYSVIYRDITAIKKL
ELELIKSKQWYKSLFTNHHHAVCMLNLDGTILNINSAFLETLQLSASDVLHKNYRDIAKR
LGACNYKRWNVYEEISYSTELTFRRSQHSIQHVYITTIPVKVNNQTVGAYAILHDITPQK
EAEEQLAYTLKELENIKYALDESASVMIINASGTITYVNDMYVQYSGYEKEDLVGKYYRD
AGLNHDHHELLETIKSGKVWRGQLEMGTKHHQSYWVSKTIVPLKDIDGNINHYVSIHNDI
TEQKALENKLHFEATHDSLTGLPNRAMLLKELNKVIEKGQQKSDEFFALLFLDCDNFKQI
NDEYGHHIGDEFLKAYTKRLKSCVRKGDRIYRLGGDEFIIILNVTNGREIEQIARRIHVS
LQQSWNVRGYCLRTTTTIGVSIYPEDGESAASLLKNADDALYKGKREGKNNYILYQT
>A0A090GV08|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium plurifarium|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTASNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRDFATGDAKPRVLLVDERKSSVERIQKMLRNSAE
LDVATDPNAGFFQAAETPYECVLVSTAFTGFDALRLCSQLRSLDRTRFLPIMLLADEGEE
GRILRGLELGINDYLIRPIDQHELTARLRTQVRRKRYNDQLRASVAQTIEMAVIDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDTYGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGLVAEKVAERIRAEIAQAPFAVGNDGKTIEVTVSVGV
SSLLKGTDSVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A447LHP4|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MLDINELFRDEFSVLEEARAAAANATLPADACREELLVLALRYQRLIRESYRLISRSDRA
ERELNRINEQLQQLASQLEYEATHDPLTAVFNRSAIINQINQALRQGDVALILLDIDHFK
RINDEHGHPMGDKVICSLVARIRRAVPDFAAIGRVGGRRVHDPVARGAD
>A0A6P1Q178|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MTTDTFSPAYNDASIFRPALLLGLLCFFASLFCLALMALDNRISPLWYATAIMTAVVFRQ
RSTSLVILLTACLLGTLGANALFLGLRWPPLAWSVINLLQSIVGGWLLRRLLRADAPLDS
LFSWCKMAVATGILTPLLGGLMALWWQHVSGGVPGLHFFGTWVLSEVIGMLTLGPICLLW
QSRYFQRITQQALLEMLLTLAASLLLCCLALRFLPWPFTFVIVILFWVAVRLPRLEAFFI
FFANVSLMSLMLAFHLIELHTANPYFMITAPWLPFLLVLIPSHIMTMVMYAFQEEKKHIS
ASEAENQRLMERITLANEAGGIGVWEWDVTRNQMSWDKRMFAIYELDDSDRPTYGFWLNR
LHPDDRTLAKEAVRRTLEENQPFILECRIVTRLGIRYIRSQANMLFNADGKATRMLGINQ
DVTELRQLNDALYQEKERMLITLDAIGEAVISIDEELRVNFMNPVAEQMSGWTQEQAEGK
PISTILRITHGAHGVEIENILRCNLPNATTVTELDRDLILHNASGEQFAIHYSMTPLKTL
EGKNIGSVLVIQDVSESREILKRLHYSASHDTLTRLPNRASFEHQLKRLLLSAAEKQQHA
LAFIDLDRFKAVNDSAGHAAGDALLRELAELMSHQLRGSDFLARLGGDEFGLLLPDCPLQ
DAQQAVQRIVNAINDYRFLWEGKLHRIGASAGLTTINVHNCQSSEVLAQADLACYNAKHN
GRGQLSVYETRLQREQQVALSHADIVRLIAQPIRWQAWAVSAPHKPQSANFHLLQARILD
AQDHEVDVEAFRASLTDAALRQQLDEALLNSFFNQCAAGVARKALNVVLPLAAESLLDPQ
QLDRLLDRLDNSPLHGDLLIVSLETSMLLNHAHHLFPVLLRLRQQGCRIMSRHFGRNLDA
FDRLPQDAIDFLQMAPDLIANVHCNLMDEMLVSIIHGQAQRLRIATVAGPVDLPVALSTL
GSIGVDAVWGGGG
>A0A0S4L421|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrificans|TrEMBL
MAKQTVSDASRLSDELARVTRELEHAQGELQHSHQRLTSLYRLTDALASSPDEEEIIKVL
TKGLPPLIDPAMIGVARANRNRAWVWSDSQNREREAQARRYLLRRLGPSPSHETESNAPL
RRGRPRHLRLIPPSAPQQAIQEQDATFGEEVSLALGSDETGLLLVQLKDPDRFTPRDREV
LDTVGAALSLALRHAQTQQRARAMALHDPLTGLFNTHAFERALMRELSVGLRYGVPACLL
LLDLDFFKIVNDRLGHTAGDQVLKEAADLMRGTVRDSDIVGRCKGNTFAVVLPHADRQQA
RALAERLREKVERHPFTVEDGHVRTTASIGLAAVPDATVVSIAEWMMVGDTALNDAKTQG
RNRVVLHAPKPPGVACAVALSCAA
>A0A447LH05|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MIFPDKPPNETERLKSLYLIDLLDKNNDERFDRLTRLMKLTFHVPISALNLLDRERQWVL
SGAGIDIRETPRNTSFCAHAILAEGVFVVKDALKDKRFRDNPYVKDKPHVRFYAGYPVRL
PDGMIAGTLCIVDHVPRDFSMDEANALIDFAAIVEDEFLIISKAMSDNVTDLMNKQSFLK
LGQSRFEKFTKYGLPFSLIYFEIDNIKSIRDVLGDREADFVLKNFSAYIKSTLKKHDIGA
YLGQGNFAVLIEHDTANADEQYLFNLQCFMDDINKKSTKAYHINYGYGMTNYDPADHRSL
LMMLESASRTTYAEKRRKEPQ
>A0A5P9IVA2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MKIILYLAISLLSLSSFANQVPKNIPSNVPLSHYFAETWDTRDGLPHNSVNALAQTPDGY
VWVGTWEGVARFNGRTFKLFTRGVLTGLPDSGIRSLNVDKATQQLYVAGSRGGISVVERE
RWQALKPAQTMVNFAVRSGDGALWLALEDGGLVRRTQQGDEQNLLPNVSAYQVFEQQEGR
IWAATNNGLYYYEDGAMHSADSDNSAITGAIYSLAEDRDGALLVGTEQGVWRYVNNEFTL
LHNALADDSVSSILVDFRGDIWLGTINQGVFRFSEYGLEKLDANVGLPSNRILSLLEDNE
HSIWIGTNGGLFRLRQAPFTTVNTARGLSGDYVRSVLSHTDGALYIGTSNGLNRYTQGQV
EQISSPLDAPISVLSLTSSQRGGVYVGTYTSGLMYFDGQRLTTVINRDTGLPSNEVRALH
EQADGTLWIGTAGGLVRMKNAEEVTTLTDKQGLPGNFIMALAQDKQQRLWIGTGVGVAFY
HQGQFTTLPLREHFDADYAFGFLVQDDALWMATDRGLLHYDYQSHRLRKLGREQGVPVDK
LFAVVNDKYDHLWLSSNRGVIRISQAHVMASLDSEDAQLEFTLFDEGDGMLSSQANGGSQ
YPAVRHHDDSVWIATARGAAVVDPAKLVRMASVSLPVSIESIGFDDEQGFLPNLDKTSLT
VPSEADRLSIAYAGLGFIMPERIEYQTKLKGFDDNWINRGNLTLTEYTNLPPGNYEFHVR
ARYPYSEWPASAASFHFTITPKFWQTLSFKVAMIVVLALALFTLYRLRFLHLKRSEAQLK
LRVQAQTRSLAEQAKAFEHQATHDQLTGVANRRAFDKWLIAHFEQAKQQQQPLSLAIIDI
DHFKNINDKYSHMVGDKVITEVANLIHHCAPQEAMFARWGGEEFTLLLPGFSLHEAQVCA
ERIRVLISGHDYSALADGVHITVSIGVADSQGAQDYDRMLAQADNALYQAKQGGRNQVVV
YQKPMP
>A0A1Y6ME19|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MATLIKSTQLQATNFAYIELSEKTLRKQLSLLFPFAGAICAIIAFTYFVSQQGHYFTLVG
ILGMTLCYTLAALNRTLFSATILFWIFLIATTLVCSSGFYFTGARHISNTIGLTIPLLSF
FALQIRTATWYSSIFGMLYIVLSVSEIANKQMQISSALQNICAYSTIFVMAFLLSRHRYD
AILQVKRTTTNDFLTGLLNREGLLPLYQNESSRCKRYRRDISMLLINIDKFREVNDRFGL
DAGDKTLMMLAKCLRKMCAENMHIARLSSQEFCIILPDIDIQNAEQFAINIRDEIGQWVL
ELTTGHQINITVSIGITNIEYQDFSYDYIKAESALMRAKRWGYNQIATNE
>A0A8H9RXC2|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFVFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARQPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A517X7N3|diguanylate cyclase|EC 2.7.7.65|Gimesia maris|TrEMBL
MTPVLATILSTLPNEILICFGGGVLIAASLGFAAGYALGKSTPVRNLRRAQKHLQNCYQH
VKETLDTACAACSLLEKFPGTILTSDQTRELNSKRTSLLSLINRLVERKNTEPEKTPPVT
KQEKKKPQDFPTLQWAFQPEHSHLKLPDSSAFEANLEMLLLAGTSTENNSGLLLVQMNQH
DQLKERFGIMAPIKFMKTLSRLIMHNVRDEDVICLWKSDTLAILFPAVEVDAGQICAETI
RDAIRHHHFRLESNSPEVVVTASLAYLNCVPGDSAELVLERGLHALAQSQKQGRNQLIIQ
DSHSYEHKQAV
>A0A7W5HP00|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. Tn43|TrEMBL
MYPLDPAPWVWGMMLFNGLLWPHVAYQWARRAEIPFRAEHRNILVDAFLGGFWVAAMQFN
PLPSAATLSMMAMHNVAIGGVRFLLLGAVAQLLGIGVGLLVFMPAFVPLTSPFQLYACLP
LLSIYPLSLGWVCFHQAHTLGRHKRELLALSRTDSLTGLLNHGAWKDQLEIEFQRCQRQQ
QGGAIALIDIDHFKTINDTYGHVAGDIVLRRLSKMLKQNLRATDVAGRYGGDEFCVLLPD
LPLDRAAVAMDALRDRFATLGYEQNPPLKVSLSIGLAAFNPAHDDATLWLNDADQALYEA
KTTGRNRVICHSDGKPHKALLNSV
>A0A658YRW9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
METEYSLAFILAVLISFSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAP
EQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLV
LSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQ
SCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILA
RLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTL
LQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGA
GYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQ
QALLHKLGVQYQQGYLIGRPQPLAD
>A0A380AJR4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYLLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVTERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H8Z676|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7Z1J084|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7Z8GFV3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDNKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A7Z8GLU9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7Z8GL53|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHSAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A087BCR1|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium magnum|TrEMBL
MNKNTEASLVVVDDEPSIRELLVASLHFAGYEVAAAASGSEAIEVIEQTQPDLILLDVML
PDIDGFTVTRRIRQEGITAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREPAEDNPIIRVGDLEINEDSHDVTRAGQPIELSPTEYKLLLYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESCISYLRKKVDDITVTDEDGTTHKVQPLIETKRGIGYMIRA
PKE
>A0A7H8SJP4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. NEB 394|TrEMBL
MSDECMAKLAEQWGKICQHYSVNDHVKAQNFIQKHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAMNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAGLPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTRKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A6N2YPT1|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MQRDTFVVKQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALLTPLGFDVLHDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A2Z5SHI1|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MRRASLKTKTALFVLLVFFTTAPTAVYLTLEFFGRSLRDVVNTHQVTLLARIGAEIDEKL
QGSHDALINIARLATADDVASPESARRFLHRYPLLAAFFDNGVFMFTPDGILLAETNQGL
QRTGLDFSAREYIRQTRTSERPYISRPFVSSQPHHHPTVMFTAPVFTPNGTLVAILGGSM
DLLKGNFIGSLASTRIGKGGHFYLFADDGVLIMHPQRENILQQNVSSEVLNHASSVPRGG
VISAETVSDGTPMLSTLKKLSQTTWTLAADLPKEEAYAPLRMAERSAWAAIIPWGLLSVA
AIWLLMRRLTLPILALECQIREAEDSGAHRNVLIRSGDEIERVAEAFNGLVNRLIEKEDR
LVHLSNHDSLTGLYNRLFFEAEMQRIDRGRHFPVSMVMVDVDNLKTVNDTFGHTAGDALI
IKAAQALRAAFRSEDVVARVGGDEFAVIMEGSDHETALDALERVRETVALLNSDGDSPEL
TLSLGTATATAPLTLGQSWRLADQRMYADKARRKASKVIGSGSASRDSAVSAS
>A0A1V4W4K4|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MKKELFEELYCLSFSQIKEPARIVASLTNTFRKALNLRQVMVCCRNSEGYEIISSSPLIN
SDLEKIQQLKNCIQFELKDRNGINKGILYLVLKKRSEMTPKSRKICSAFATQISGLLALP
EADYCGEQNYKKEIDHYKNLLIHDKLTGLYNRYYFEEQIKLLEGSDNYPVSMIMIDVDGL
KIINDTMGHRFGDKALIIAAKLLKYTFRKEDIVTRIGGDEFVVMLARTPQKVAEQRCKKL
SDAMFKYNNFNKIPPISLSTGCATSNGPEQPLADTLETADINMYSQKLKNRSTIKSSLLT
NCRSFSILPSENTIGV
>A0A1V4VY05|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MIIAVLTEIIFASYKNVYGVTNFCGHITRAISDIVIYRGVVLHGLESPYNVIFKELKFSV
IIEPLTGLYNRQGFIELADIEMIKASKEQRSLGIILLDIDKFKKVNDQYGHIVGDNVLKR
FARIIINSIQNNGIGCRLGGDEFVILSDEKRIDSIIQSLYKELNLWKNIDETVKEIGISF
GTVIWKPSDSKTIINLIEEADQRMYQQKKNKNYSRHN
>A0A8F9C0Y0|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MGMNHNGSHDPRAVADEADAALEAARATLDTPPAADVPAMVLLVDDQAIVAEAVRQALAG
EEGIDFHYCAKAEEAMKAVIYTRPTVILQDLVMPGVDGLTLVKAYRSTPATRDVPIIVLS
AKEEPVIKSAAFAAGANDYLVKLPDRIELVARVRYHSRSFVNLLQRDEAYRALRQSQQQL
LEANLELRRLTHSDGLTGLSNRRYLDEYLSAEWRRSAREHAEIAMLMIDVDNFKQYNDTY
GHVAGDEVLKRIATTVEKCLGRAGDIAARYGGEEFLVVLPSTAAGGARLLAEKIRLEIEA
LALPHRNSLAAQHVTVSIGGAATVPTAGSAMTSLIESADRALYEAKRKGRNCVVMHDGTE
QGARV
>A0A128FF85|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MSKEIFAQSSGYLKKVVPLLMKYQVPATPPNYALWYTYVANADIELSKKIDESIKEIGTL
SPTLSEELYNDHVADEKVKDVDEFQRGLQALALEMSNTMEDTLKDTATFQSTLDKTFSQL
ARVGEEALSMEETVAVVRKAVKSSNELRQSTNFFKSQLADAQEEISRLKETLQQANEDAL
HDALTGIYNRRAFDTELESLATSPPPKGFSLLLCDLDHFKSFNDTYGHLMGDQVLKLTAR
RLSDYCRDGIHAYRYGGEEFALLVPNRPLSGGCRVAETIRATIDKLAIKDKKTGKKLDSI
SVSIGVAEYEKGESIRNLISRADAQLYEAKNLGRNRVMPVT
>A0A128FHV7|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MHVLFIDLDGFKAVNDQFGHQVGDELLKVVAERLKSSVSRRDFVSRLSGDEFLIALYGNA
PVDKIASRLLRKLSDEIVINNYKPRVSASIGVRYWAAKDASSLAQVIEQADKAMYDAKAN
GKNRYSLAENLAALMEEV
>B2TYB5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTAGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILEHAESVQKLRLAGCRIVLNQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A238DLJ2|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MQAPARAALQRLSKLLLFNAALAGVYVLLAWLVMRSGAAGALLWPSSAVAVFGVMVGGWA
AAPGIALGAYLANAFSVGWSPLAALCIATGNTVGVLIAWWLLQRLRRPWTGLQGTGNTLA
FIVTLGLLAPAFSAGGGMLATLLPPLPPMHNLGGLWLSWLVGDICSVLIFAPPLVLWWER
RNDALPAPTPELLGVPVLALLGTVLIYFAPPTTQALPLGLGTLVLLPLLWAATRLPMRLS
SLLMAALFALELAGTTMGLGPMTALPPMDRITALQVMGISLACTVLLASSLAQDRGAALR
QLREANARLERAVERRTAALVESQTRLQRQLRFQDSLLSALPNPTAYTANDGRLALINKA
FTQLLGRTHDAMLGRPPEDVFEDSLLHTWTAMDRKLLAEGRPLSQECRQLPEDGEESVWI
LNKAQVADSSGKPLGIVTSLQDISELKRLQDQLQRDEQRFRFLVDASPVPLVIIRLRDSG
LMFSNRASDELFRASHAEHHGKPMRSLWAEPGQREAIIARVLREGTVSGQEVKFRRFDGS
LLWLLLSITHTHYQDEEALIFAFKDITPTKQRELSLQELAYTDSLTGVSNRRHFLAQASA
AFHEARRLSHDLALLAIDVDHFKQLNDVYGHPAGDRALRSFSTVCKSQLRSVDLFGRLGG
DEFAIVLPHCDGLRAYDFAQRLRLAVQESAGMDHAPLRQQLTVSIGIADAADSEAADRGI
EDLLARADKALYQAKQRGRNRVEIWSFHDLTLP
>A0A6N3H7A6|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MINSENSSNKITVLYIDFDRFKSINDTYGHDVGDEVLIEISKRLAITNNKDNILARLGGM
NLY
>A0A1A8T6Z6|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MHPNKHHNQHVPNLPLAVHKGLSLIICAITFFYSLWNLVYLKLYLLASVELIIVSFSLFF
FIQALKNQDKEWQHYTLVGMITVLVLLTPLQGDIRAGSLYWSILLPFVYFMMFGSRGGLI
LSLLLVFPVLYIIYTKTTHEGFLPYRAMVNYTLAHFCVWCLCYVYESQHQKDNLRLRNMA
LEDSLTGLKNRYALDAAFEHIDQHNIKAFMLLIDIDHFKAINDKFGHDIGNQILIEMADN
LQMYANEEDVYRLGGEEFIIILSEKCEQEIYSTAESLRCFIENTLFHQHDLRLQLTISVG
ISRFLPGQSLSDFLRSADHNLYLAKQQGRNKVNHTLF
>A0A6C7IC93|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain D23580)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPRAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1A8TNC9|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MTGTGWLEGINKLLAELGKATLVSRVWVFQTLEVQHDYILQDYAFEWYAHTKYKQIGLPH
FNRFKSPIVEPEYIALIESRKRGEYQSVMTRTLPDDWLKNHLVSQGVKSMLTIPIIIENQ
WWGTIGLDDCEREYKWTANDITLLRTASYFISSAIVRDHYRAKQHQLDILKENIACSSWE
LDWRRGHLWCTSEVLTPNEKQVTRQLFSLRQWLRRIYPQHRKPFLKTTLQFLKSDTSTLR
CDLKILRLDGQYCWVEVSSNIVKSSAHIDNVIAGICWDITDRKNDEERLQHEATTDPLTG
LMNRRKFEILMKNHFMEWTQQSQPFSFAILDIDFFKSINDRYGHAAGDYVLKQFAHIIRQ
LIRPCDHLARIGGEEFAILLPDTPSNDATTRLKKICRHIFTHPITHQNDLIHYSVSIGVA
VIESPKTTADEAFKTADRALYQAKQTGRNRVIAVLL
>A0A5Q9LGV4|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MPECHTPANRSIPSALARGTLLPALLVIVAVAVGCALVSPPIGTWREILANPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDTWGHLVGDEVLFSLGKQLAKLTSEQVLPARIGGEEFAIIVDGLSEPELHAL
AQSILDNARTILINHQAPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWA
>A0A380WMM3|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MLDRLNAITHRRWGQVALLTLAGALLFVLVGLAFRMLVFAGADAEMLWREAVNAFVLPLL
FITPLLVLLGLSETENASLRQKYAQELAHDSLTSCLTGPLFTAAIDVVATSSGSARRPGA
LLVVDIDHLRRLNEQIGYGAGNQALSAVAGIIRASVRSGDLVGRIGGDEFAVYLPGANKA
NAEKVAERIRHAVAEAHFEPVAGGLTWPLTVSVGAVLFETDATADELLLTADRQMQAAKD
KGRNRIEYAHLRQDSSSSHPSLH
>A0A380WLY2|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MTGALLLVLQALIYFVTMAAVFHSRHRFGIGIFVCVLGVMHFLETYLAAVFFVQLPFGLI
SPGSTVMFSGKLMMFLLLYIKEDAETVRQPIYGLLIGNCLMVALALILRLYGNVAEMPGY
QPDLTFLDDMGVLMVWGTALLFLDSIALILIYEKLGQRIANTLFKRIFLSAALVLTFDQL
MFFLGLHLVSGVPISALYGGWIAKMAAAALYSTMLVVYLRHVESRPALAGPEPLLKVFDR
LTFRHRYEDLLQKTGKDTLTGTSDRGHFEAVAQSLIDRPLADRQPVSLLMIDIDHFKSIN
DQHGHVTGDKVLKDVARALDGALRSGDRLFRYGGEEFVAICQDLNAGDATILAERLRSAV
ATMTLAEPGLSTTVSIGVTTAKSGPVSAEQMIRDADTWLYRAKRLGRNRVESPLVA
>A0A379ZYZ8|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MDFGLATELYPDEYRYQTEHYSPNDNPLDLVQVIQQLHASLDPRTVFACYGKVLGQHLPI
QGVRLSYGEHKLSWGKRYGISVKRQLICAGMPLTIQYQLLTPLTPSQTSNLKEIEPLLLQ
PLLNAMQYQEMSMQAMFDSLTGLGNRHYYGQSLSNATARAHRKQGSVALIVLDLDNFKQL
NDKFGHKCGDYILKEFGDIIRATIRNTDQAFRIGGDEFVIIVQGNIHAAGLLCERIVSAI
NQHSSFTQFGVSCSLGAAESHDTIEAEQLYELADKALYQAKAAGRNCYKLSQNQLV
>A0A380WH07|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MNYYNVIGLLNTSMAAIFCIALLTIWRNNRALKYIGVLGLSYGIRSLCFGIFYFAFSLEN
PVLRYSANIFLLFAIMLLSIGLSNRRLRQPRYGALLAIAAITLGPLYYYQFIEPNLLARV
IILNSGLALLSLLMLWDVAKAPRRSPVEQVLLGLLLVSCAGYLLRPLFLIASGASGERFE
GSYWLVVSISDALICAMTAVGVFAVIASDVMDEIKTDALIDTLSGLFNRRGFEPLALRAL
SKRTAGTPPAMILADLDHFKSINDLFGHSGGDLIIRRFSEVLKQKAPGDAIMARLGGEEF
AVMLPSNASDSAYQLAEEVRTTFKQIAFDTVAGEAHPTASFGVAIAREDEGLPSLIERAD
HALYRAKGNGRDRVNLAE
>A0A080MC99|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MFSSPPLPPFVDLRADDVEIGNYATLLDSLDIALLVFSPDGSLHLRNNQAATLLGDTPVV
WEDENGQPLAVDHRLEMEVAQTRQAILHRAIGIRKTVSGATAWCKAGAFPVFADDGSLRR
ILLALAKLTPYSHLASESRPMPTHDLLTGVFNQRYIRLLLDDEDRRARRYGTPFALALIA
LDGFADFCAANGREAGEQVLAEVGSLLGKSLRGFDMVGRFGSDQFLLILPNVCIHDAMLG
LERVRETVEATYSRHVRLPWTISGGVTEYSGEDSATLIEHLRPLLIAAQESGGNRLCVDP
EIL
>A0A380WRQ6|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MRIATITHWAYGITVVLTALSGVSFMLSSNSALQERAAAEEHLTLDTLAEELALGAEVRS
DEARLYVMRGEERHLQAFRAREIAERRLEAVTSELAARDPAPAEVAAIQAIDGQAEELDK
IEAAAIEAYQNGNKAAAQEALFGAEHERVQNALLQTVAHFRDLTAVRTTATLDAARERSN
WWSLVAKIMLATTGALFLAVLYFVLSRRVATPLRHMTGIVSRLARQDYSVELPIHRRADE
IGEMSDAIEGFRTNLIEREKLDAERLADQHMKDLILQMMHRVQACRDQVELTDVIVRFAP
QIFPELAGGLYVLNEGKTALARAGLWLDPEHSASEFPATACWGLRRGRSHHSGVNGADVP
CQHVDPPGVATLCVPLTAQGDMIGLLYLEEREDGALEPAGPRLYLELIAENVGLAIANLQ
LQEKLTALAVSDPLTGLFNRRFLDETLRRHARDRRDEPLACLMIDIDHFKRFNDQFGHDA
GDLVMQFVGQSLREACASSGDAFRFGGEEFTALLPSFGEADAVALADLLRDKIGSVALSH
AGQVLGAVSISVGVAASPTGGSVETLVTRADAALLEAKAGGRDRTIAASKIRKSA
>A0A080M3F6|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MMSKGKGRTTATDLAGPGSKILAGGFSPRLCHRLAACIAAMATLETISSPIIPYIAAWRE
HEKVIWYEYVGAKFLALLGCDREEVDEVFRQSIVDRRLYRYADRESKVEEEIVTRAELRG
DQAGLREEVKKAGAVEFVYQLALPEGKRIWLKDQANIEVFVEDRICLSIGCLTEVTKEME
QKDLLEKIGYFDELTKLPKRTILQRILEMNIGNLRRGHVTDFVFLLLDIDHFKAVNDMHG
HQAGDQILVGFAEVMRATKRHEDEIGRYGGEEFYGFSIGSLNNGIQFAERLRQAVAGSEF
VFDRERVPVTVSVGLVAASQLAGDGEISAEELVRVADRRLYLAKEEGRNRVVFRG
>A0A380AEU8|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MCLIGTEPREFTAEDIETLTDLGEMVEAELLSIAQNTLDPLTTISNRRGFELLAHQALAS
CRRTESEAALLFFDLDFFKEVNDNFGHLKGDQVLYDFAHILMTAFRESDVIARLGGDEFV
VLLSFVHRDTVDLVIERFKQLLEQYNQQHPKQHSLAISIGIAHWTPDSDVSLEDLLDSAD
KAMYQDKAAHHSDAP
>A0A1Y2N309|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia autotrophica|TrEMBL
MPPRAGRRRFPFRSWQIGALPPAALVFILSVDVLAVGLLVACVLRAPVPTGEQLLLAGLL
SLVPVAHTELSLHCERTRRRVARNQHVDMTSVWTFCGALLLPPVLAVAVVVAVHTHRYLR
VARAAGTPAHRHLFSAATVLLAVCTVGAIRYAAEILAPAGSDPGGATVVLVALLGYSVVS
TLLVACAVRLTRPGTRFLSVLLGAEFLLELASLSLGGLVAVIIDNTSPWLALLAVLPLLV
LEQTTLVRQLENQVDTDTKTGLLNPSAWRWRAQQMIEQCARTERATAVLLLDLDHFKAVN
DRHGHLAGDDVLRAVASVLTAEVRDDDLAGRFGGEEFVVALGGLRPDDVVFGRAREVAER
IRRSVRALEVDTATAGRVGGLSVSIGVATSCEHSGKLDALLAAADAALYEAKRGGRDQVR
VRHPEAARHPGTATPPFGLHLGTGGV
>A0A378UN45|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MRLALSPRSANQYYTLTALLAARGAQTYTSRVIAGCVFTLGLITLSTIGSSATLQWPFSR
ALLIVVSALCFTSTFIWLRHRWPTRNESALLVAVAAVSIAIGSIIPVVPLYGLLGASSFA
LIVGYTALFHGPRLLATVLAIALGTLLYLAVQMAGDDLPLTLAGVALILLLYVFAAFSCR
MVVWLTGAEDGADAVEPLTGLLNRDAFYLQTATLLASRNRGDDRYLVIAVVNIDSFAAMV
AVAGNRGANRARVAAGQALRETVRRDAILGHVSEAEFLVADCFTTPDSSPLIERIRGAVA
SSPAGMTASIGVVSTPLQPLVEHPPHEILDEIVALATTAMYEARRAGGNQARYVVSPNLS
ISDGDNDEHDTPML
>A0A7L6YRE6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C16|TrEMBL
MNDENFYKQAVDLDETSLSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPMSREFANLKTDAVLAGMWMGLMGVNALPSAA
LLMIICMNLMGAGGVRLFVTGLALMVVACLVTLQLTGTSLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATRLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHREATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRITLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRIHEGLRGLRLACAPQVILHISVGVAPLTPQFSHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A1J5R1E0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MHSTILHTLLSHLVELTSERDQIELEKLLTQTLFDLISLESRDHDQPSVSIYHAVDIEKQ
IFPIVALSQEAEEANLPSSLKNNLANCFKSGECLSYTPNGKVFTHLYPLKSAAHQPIAIV
AITSEIEDPQQQISIRMLLQMFQNFTWLNHDNERDTLTGLLNRKSFEQRISKVLAHISNT
SKRKDDTICHTYFLAIFDIDHFKHVNDTFGHLIGDEVLLLFSQLMTQTFRDTDMLFRFGG
EEFIGVFQCTLASDIETVLERFRVKISNFKFPQIGKVTASAGYTLISADEISSKLIDRAD
TALYFAKNNGRNRNCYYDQLITDGLLQENTKESDVEFF
>A0A6N3EXQ4|diguanylate cyclase|EC 2.7.7.65|Clostridium paraputrificum|TrEMBL
MNKVKNTKETQLRNIIDMIKIISLLSLGIILCKYLYYRNTISQENPYEVFSLKIVFLPLL
FLVIIYVIWISSISKESNKWYINILKKYEMEIYIILFSVIIIFFGGYESEYKFLYLFLII
SATIQEGMKKGISVAGISSGIILIIDLIIGFCDKVNNNFEKDLILSAIFIVTAWILGIYV
RIEHEYIEHLEEVVNKDGLTEVYNHRFFYESLKKMISECKEEKISLIFLDIDYFKHYNDL
YGHQRGDEILRVIANLISNNVRDGDIVARYGGEEFAVILPNTTEEEGLKVAEKLRKEIEF
TYFYGEENQPSGRITVSIGVSVYPDKAKDDLELIKCADDALYRAKFFSKNRVESYSSVLD
EITKNIEGKDIELVTSIKTFISIINAKDRYTYGHVERVVIYCRAIAEELNLSKSDRDTLI
YGAYMHDIGKINIDEDILCKKMKLSDDEWMQLKKHPESGVKIIKQVKALRNVIPLILYHH
ERYDGKGYPSNLKGEEIPYLARILTIADSFDAMTTNRPYNVRKSFKEAVEELRKCSGTQF
DKEIVEVFIKALGKSNTLIK
>A0A735ZS91|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DCVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A727RQD5|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2S4AIX7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MQHIPNHQLVAEWLRLLDGYPAEAAAALQSVAEQKSAELAEHFYSQMLADPHSASFLSHD
QVKNRLGKSMQKWIVTVCCSTSRSDLDAVVDLQRKVGDVHARIEIPVSLVLRGARSLKGR
LRQLLELRDLDEPVRRKAARMGADLIDLAVEIICFAYSQSHDRNSRAEEAYRLFSVSQNI
GVEKERQRAALLDWENQLMFDLAIGNLTGTLPQLAGSEFGLWFRHKASHAFQGSPESASI
LDYIDGIDQELKFIAALQDASGRLAKLHQIREQTRSIKFLLDSLFEQANDLEAGRDVLTR
LLNRKFLPVVMAKEVLYARQSNNTFGVLAIDVDHFKRINDTHGHDGGDQVLQQVGALLAS
NTRGGDYAFRLGGEEFLLVLVDIDTTKAFAAAEKLRERIAREQFRLSSGAVLQVTVSIGM
AVHDGHPDYERLLQQADQALYQAKHEGRNRCVLHQV
>A0A1E3KYB6|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MIIKDMFINFCIISTFLFFGNIVFRNWRSNPRISPFVLSCLTGAFLGLFGIIQMHFTFKL
DNGTLLDLRQIPIIVATVLGGGISGTITTLIISIARLWLSAPISIVSFLGIANACMTLLI
TYLVFRTRQSFSRKWVITSLISTLNSLFFFLIWSGFTKETTLILFILILFSSFIFTYLLI
ERLRRYNQLYDAMSQEVQLDFLTGLYNYRGFEMKYNQLSQEKHIPFALFLLDIDHFKMIN
DQYGHSAGDAVLVQFAEVLRRSVRVCDHCSRKGGEEFSLILEHVEQQAEAIEWAENIRKN
IEKHTFVIPDGRQVSLTVSIGIGFYPLHPCDELLDKTDDALYQAKKAGRNQFCIAL
>A0A7D5XUV2|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MEISAPNTFGTHKGVVLTHSLLVALATFLLALLSLSLSSEASHFTPLWFPTAAAIAVLYR
HAPRHWGLPLLASGLGIVLASFLLFGVSATPVKLAAINLLEAAVCALLLRRMLHPYDPLN
DLASWLRFVVCAVIFTPLFSALLAAGLVPAPGQPFWQPFGTWFISEAIGVLSLAPIGLSY
NRRTLTALNPFPLLLTLMVTLAFSFMALTYLPFPFTFVILPLLWAAIALPRFEAFTVCFC
TLLLITVMISLGLLHFQASGKHLGDLGLYLPMLLILIPAHAMAVVMHAFRVEKQHIVESE
SRFRSALEYSAIGMALVSPQGKWLQVNQALCALLGYTPEALHKLTFQEITHPDDLTADLS
QLHDLLDGHISSYTMEKRYIRSDGQTVWALLAVSLVRDAEGLPLYFISQVEDISDLKRSQ
AENNRLVERITLANQVGGVGIWEWVMSQENFTWDQRMFELYDLNPDQTPTLALWRTLLVP
EDRDRTDRELAALLADPKPFVMEYRIVTRQGSVRHIRGQGNVILDDQGRPLRMIGTNIDM
TELKSLAEALHEEKERLHITLDAIGEGVISTDSHLRITFMNPVAEQMCGWPLDLAIGMPV
AGVVRLTNGKDGPEIENLTQYPRQWPADYALVLHSRDGRYFDVQQSVSPLKTLDGETMGA
VMVLQDVTASRELMKKLSYSASHDALTGLPNRASFEKQLKAAIVAGGEPSPPHSLVFLDL
DRFKAVNDTAGHAAGDALLRDIAQLMRHQLRNSDCLARLGGDEFGLILFDCRPEQAKSLM
QQVVNQISQHPFYWEGKIYRVGASAGITRIGGDAKSSELLAQADIACYTAKHHGRGQVYL
YEARQKQLLERQHELLSLQEVQTIVSEGQLRLLTRAVAPPATPLSAAFHQVKLQVMAPDD
RPLPHEAFIAAAQLYGLMPDIDRWTVAQLLVHCADDIKRKGLSLALPLATDSLLNTDFQR
ELTERVRASSLPPQALLFSVDEAVVLEHAAQCRACLRELQQLGCRLIVNGFGHNINAFDE
LGDQKIDIIRVDERFITNVHCNQMDELMVSMLNGAAHRIKAQTLAGPAHQPVTLQALRDI
GVDLADGDQVALEQPLAVLLSDGYFGIR
>A0A1C6IXQ2|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MTGVLNRRAFRADVEHELRKKQPGIFLFIDVDNFKSYNDTYGHSNGDLCLKYFAQTMQEC
FPKDSILGRYGGDEFVAYLKNVKPETVYACMESFQKKISHFTLSTGEVVELYASAGGVIF
PEQGEDFVSLCKNADAVLYDIKQNGKAAFKMK
>A0A6Y0Z2X3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2X3GPS3|diguanylate cyclase|EC 2.7.7.65|Listeria fleischmannii subsp. fleischmannii|TrEMBL
MLIEIIMASLTNVFIVITGCYIINKIIPNEKKLSLTWKTTSYIVLAATVTNFALMFFAVK
LPNGIQADLRFIVFMLLAYYIGAQQASLTALVACGIRIFIGGGLNEATAFGVFCTLAVAL
PLIFIAVKLRKSKLHQIQSFLLLNTIGVTIYTATLFLYYGYKPFVFLVGGSIFIVSFVAL
FSINFLINDMLTTRRLLREEVEYAYVDFLTGLYNVRAFSNRTKEFARSPKVQTLAIFILD
IDFFKKVNDTYGHASGDRVLQSIAQTMKNKVAISENLFRVGGEEFCYLLPNVSNETAFEV
GEEIRLAIESHPIMLSSSETIQATISIGIASGEKSRKQLHKLYQYADKALYEAKHTGRNK
VVLCSQDEIESLLLLRGKA
>A0A449BEQ3|diguanylate cyclase|EC 2.7.7.65|Haploplasma axanthum|TrEMBL
MKITHQIDINLFMIFCIIILLIIAKFTLDKKNILTKTFFSMAIITLTQLSLESIATVLDG
APGKIIGPLLYFIYIVMFILSIFLSLYWYLIMKRFFKIKNDVYKTIEKILFVIQLINIIV
IILTPLTKAVFYIDSNNMYNRGKLFINQTFAIYYYPIFATIILLVERKKLESNDFVLLLL
SMCIPVIGGIAQAIFYGYLIIWPTTAFSLILTYIFIKQKMIQYDALTGVWNRGSLFEYVK
QRFNLDEKNIFGALYFDIDCLKQINDQYGHSAGDRAIVEITVIIKKIVGNNVVARLGGDE
FISILDVATNEELNVYSTKIKEEINEFNKKNILPYLITVSIGGDIFDSKFKNFDNFLHHI
DILMYQDKSLNHREINK
>A0A1E3A910|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MLRIDNLKVTIYAADKKIYSFGEKGTFPHYARSAGNGWDSLISPGISSDDYVRIELENLY
TNHSDTAFSVFFQFMYYGYEGELITSLIRSKAMDLLLAVFIFCLGIIAIVYCILLYPLKK
VVRQTFCFAGLSLSAGLWFFIDFNVQCYLIPLPVFNNSLDIVCMIITSVFLVSYFILLLH
TRWKILLSVEAALEFILLPAATAAQLMGIYDYYDFVNVIIVFTILEGISIPAMILYENIR
FSDKINHSLIDSLALVAGMFLQIFGEHRENKTSLFWFKLGFFIFLILQFWHMAKSVKGII
ADSTKAALLEEQKQELIEKVQKDPLTGLYNKSATQKQVAGALRTGNPDSLAAFLMIDIDY
FKKINDTLGHAAGDSVILIFAGNLRKQFRDGDIVGRIGGDEFAVFIWVPDEVWICEKARK
INAALAENITLESGACSITASIGIALAKCEDAEFESLYHQADEALYRAKAAGRNQYSL
>A0A3E2KW63|diguanylate cyclase|EC 2.7.7.65|Citrobacter gillenii|TrEMBL
MEQVAPANDTLLLTEWQALLRQTSPDVHTILTSLSDEEIHHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFNWLRSVLGSAQEDLSQLLLKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKADYPPHLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLNTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPVGELVFLANSDFGMWFSHKGKHIFGNSNLL
AEMESVIAEIDNRLTQTLLNLQQPAEAVRMSLLQDVRQLSAKIHYLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDSYGHNTGDMALKSV
AAVIYEHIRSSDYVFRYGGEEFMILLVESEVSQASIILETLRKKIADLRMAASATESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSRGRNRVETYQE
>A0A6N3QRR3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A1E7WGD3|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MTQTATGKFAPNMDQAAHDAELVDKLATENQALRARMAYLLEQAERNHSIMTRHQAFDLN
IVSAGNFPELVGTILSVLPVISELDAVTLTLLDEGADIRTVMLKLDVVFADFPDLIFVEA
LEALGFELAERTTTSPPPKPLLGMFDAQRHGAAFPNAPAGLQSVALVPLLRNKRIIGSLN
LASRDPTRFTPSLGTDFVEHMASIVAICLENVISNEMLKYIGLTDSLTGVYNRRYIDRRL
LEEIARARRQAYPISFMYIDVDHFKRVNDTVGHGGGDEVLREVATRIKNELRTSDALARF
GGEEFVVLLIDAPLDSAAFVAERIRAGIANTMIALTPELQVSVTVSIGVAALHPGEAEGD
PAAIARAWVAAADLRLYAAKEAGRNRVVSTAPAE
>A0A090NDL1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEP
VIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAS
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCEVYWQ
>A0A0J6YXP4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MFDGLRSSSARSIGPALWGSDQYYWFTAVLAARGMQTATCRLVAVCIAALGLIPVGLLAS
PTGPQGTVGRTAAVVIAVACFGLATVWLRDHWPTRAQSLLCVLVGSVGIAVSALIQTNPV
VGLTGAASYAVLTAFVVCFHTQRLLALVWTVAVFALGVLIVRLAATDLALAICAAGMIIL
LNVFVAFACRAMILLIQPDTHHGDIEQLTGLLHRDAFYQSVATLLASRSRSADKYLVVVA
VNIDSFSLLLGLSGPSGGNRARVTVGQALRETVRHNAIVAHVSDDDFLIADSFTTADASP
LVERIRGAIAATPQRLTASIGVVCTPLPPLAAEPPDEVLDKLIAIATQAIEQARMAGGNQ
VRYVLRPTLDEDPDNDGDDPRPDTGKSA
>A0A378WVH2|diguanylate cyclase|EC 2.7.7.65|Nocardia africana|TrEMBL
MNGGKTLRAWWNDPVDYCWLVRSLTARSALGPLKVLVGVSGAMIAAMGAVITGSPVGPPG
HPGVASAFGVSCGTLWALRWWFWRWPGKTESLLLIGGADVLFILEFLQVPDRVFAAMGTV
LLVVTGSYLGFFHNARALAAHSAWSLLSVIVVSARIATGGGPLRLALAVGLLLFVSVVSA
LPALQILYWLLRTESLSDPLTELLNRRGLEIRLPLLLDQHPAISVMTFDLDKFKNVNDTW
GHRAGDTVLVRTAQRLHEAAGRSAVVARTGGEEFVVAAPITAEAARTEAERLRRTVAEPS
ENTVEVTASVGVAVYDTRICPRCPRPTPDRLLQSADAAMYRAKQAGGNLVVLDDLTPRPD
HYRAGG
>A0A6N3FTU4|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MTGLNPAPLVIISAIYFYQNWFFFLYAASILQRPVKKRWIVLAFFINYALFVVCSILQLH
LVINWLLVFTLQFIEIRCFFRCRLSDSFILALFSMIIGLSLNILFRCVLAAAFDLPLVSF
SNNIRESTNLKQYPVGLGFLAAGLYFQIARHFDAHMDNPRVIFQDPARKRFLIQLCLAIY
LYLVLNLLIYSVPGNILVLKLWGVKSCVFSLIGVYLAIRYAARISRLSQYRVLNREVREA
LKRKKKEELELSRIASTDPLTRCPNRQRAETVITRWLEAGKSFCLCFVDLNGLKRVNDTQ
GHELGDLYLLTVVQTLWGACRQDADALFRYGGDEFVLLFPDLPPAIIGSRMDRVNRSLRA
RSHMPGHPFDMSISYGLAQSGEYESADMLIKAADKRMYIDKENTERNRHGIRP
>A0A6N3FUW3|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MAAKPPYTPNIITAAASELLSDGIACFQSDDALTPRYLNPSLMDFLGVSALPGSLASYME
EEDLPAFKQFLNHLKPGETARTCQRLADSKGGLTWVCASCQLVSGPDDTPAVILCQFADL
QYLKRSQSASNADRVPCGVFKTLTDEDLTLLYANSFFYQTYGYTRESAEAAGFTNCRRIV
MPNEYPQLRQKIGHYIDTGVYAFELENHCVTIDRKAIWVLVRCQYNPQEDTLFGAVFDIT
DRKAAEEALRISEEENRIALRHSDKFIGRYDLRTRTLTRTGEAARLLGLPESTRDVPDGA
IESGIVAQESAADYARFFKDILDGRPEGHTSVKLRTTTKNAYSWFNADYSLVYDTDGSPI
TAILTYFDSTDLHEREVAYERWARTYEQKRENCIAYYEFNLTADVLEKYEGQTKGDIPTG
YTHSLLSLAQFTADLYTVPEDRKKFVRFFNRDHLLEKHRAGNDELSLDYRRYNRAGGVFW
ARADAQMVDDPFVGVVRLFVLIQDVDSEKRRSLELRRLSQTDPLTGLYNRATLVKRLGRV
LRRGTAASHALIILDIDHFKELNDTYGHQFGDTVLIEVAAALKDCLRSNDFSGRLGGDEF
MIFMRGLSDTAIIRERLNVLRDRLYNLDLTNTPLTISIGIAFFPAHGKSFQELYDRADTA
LYEAKRQGRDQIVFYE
>A0A378Q7Z5|diguanylate cyclase|EC 2.7.7.65|Moraxella osloensis|TrEMBL
MTQTALPSFKEQLQQTLKFFSFKPSLYINSPRVNDTNKFMLFIILALVETFFHLIWYATV
LVITSPLDIFPFAHKFNQIFNRSLMINITYLGLAMVLFCGYSLWVITRIPEQSRLWREYQ
IFFVIIYLIYENLFIVWIGNNSALEGVMLISTTGLGMVLLRWRLVWVSFVSCIVALFIFN
ISNSMNWWQLLPRLYPSLAARSHWLWGLSFSFLVTAKATVTLYCILQGMKVMSFQRRKIY
DLLEADALTNIANRRTIYSFLSYLWERKNDWNTLSVIYIDLDKFKHINDEYGHDAGDATL
ICTANTLKNFLPTGTMFGRMGGEEFCIILPNTGIEQAADMAEQLRQAFEKQVVRYGIFDT
EIQFTASLGIASVYQNHGQDSERAIDNRGFIEYMRKYMHSLPTMPALPPALEQIIKFSDL
AMQQAKAKGRNCVVKGQCYLLMTQSNQPS
>A0A066PWJ5|diguanylate cyclase|EC 2.7.7.65|Acidiphilium sp. JA12-A1|TrEMBL
MSLGRGMTESTAFYRERRAPLPPFSAILGTDQAERLAIGLTLISMALYLFCLVAEWIGVS
LNLVDATQSLWLTIVALGGEVAFYVLLRSGISRRWPDPTLSLPQMVFAITLLGAAYLINP
QVRGELLMLAALVLEFGAFQLPPRRCRDLGWFAVAVFGVAMAIGATVSPDRFDPRIEVFQ
FALMLAFLPVIAGIAGKLSQMRLDQKQQRRQLRDALKQVQILATRDELTGLPNRRHALEL
IERETARTCRSGAPLCVAILDLDHFKRINDTFGHGVGDEVLRTFGREGRLVLRADNIFAR
WGGEEFILVMPDSTLIDAQTIVRRLREHMASPECWASCLRARTTFSAGIAEFLVGETLDE
TFIRADAALYEAKKLGRDLTMTA
>A0A1V6II56|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin024|TrEMBL
MENYFILVSALFYLSIMTASFVFLTRQDNQNPRRHRVVIFLFLFTILGVIVDTLYRLDYG
GLIVLSPGFFAGVIVAAYVFLPVVWGLWYLYVAHTSYLSAIPKAYNIVVFTALIVNLVFS
LVSLIPGTNLYFTIVDGVYKRGNLFFAQIIFFLLFLALTICVYSRYFKTFGKSERFTFLL
IIATPILAIHGHLLNQYIPFVTMNNVFNFMILAMNVQYIHASTDFLTGLANRRSLSTHLH
NRMTGSDKMSNFSIIMFDLDNFKMINDTLGHDVGDDALRQFARFLRHHCKDVDFVSRFGG
DEFIIVLDNMTPSELKQRVVTIREHFKQYEGNRVGDFELDFSAGYFIHNKDLNISTSELI
RIIDERMFKDKRKRGNNKTI
>A0A2S6Q5H1|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MNDYKSIWQKYTKSKSDFTLEEYQELQLEIAFLKKQLSSQSKLIKKLKEDAHQDSLTKLW
NRRKFQEDLDKSIAYNRRYSRSSGLLFIDLNHFKAINDTLGHLAGDNVLQHVSEILKKNC
RINDEVYRLGGDEFVIIMPEVTQEVVQAKSKTLENAISQSSMFFKGQEVCLSASIGFEIV
DGSKNKNNVLESADKQMYKVKQQFHSLQLVS
>A0A1V6KE16|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin001|TrEMBL
MSMRESCVIVDENGRIVDMNQRTKEMLPFLNSDVIGEKALDVFAIFPSLIEAMIHHEEQE
IELNASFVGGPEWILAKISLLNDDRKDSIVYAIFFEDTTERHRMLESLQYYATRDDLTGL
FNRRYFYEAIKPGIVASITKDTEVSIIMIDIDSFKEVNDAYGHAIGDKVLRSCAKVLAAK
LESESDAIIGRFGGDEFIVFLPQASLEEAKRIAEKLRLSVVAMPILEEIEQPLHISVGIA
AGQIARLEEIEMLISKADDALYKAKRSGGNLVCV
>A0A518CZ78|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla163|TrEMBL
MNASRDTTDGEHDGHARSRVAALRAVLAIGVSVFAIDLWLPSSLVLGSLLILPVLASAWL
QSPRFTNVVTVACAFAGIFGAVIGLGGGATSPPTTVALQMACSLFVILVSGQLALMRIRS
EVRLDRSRELVATALRSIADAVVTTDRNDLVTLVNGPAQQLLGADAAAARGRPLDRVVRL
ERDPQTMTPADPRAPRRRLLVVTEGGQEIRRPVEVTSSPIVGVRGEDFGRVLVLRDASDV
VAFEERMRELAYRDGLTGLANRRSLEERLDLELKHARRARVRLGVLFLDLDKFKAINDTY
GHRAGDQLLVAVGERLSAALREADTVARISGDEFCVLVPEVGSREDLGVVANKLLDAVVR
PVVLEGVAVPISPSIGAALYPDDAGSADELLSCADAAMYRAKGLGGAGWAVHDGATQRWS
PAAHAAVEDPRRRPNDARSSANDAPTAQRTPAPHEGATTGNSIENGTRNDR
>A0A1V6IXQ7|diguanylate cyclase|EC 2.7.7.65|Parcubacteria group bacterium ADurb.Bin016|TrEMBL
MPNFEMPNNIMERMDKLQEADGKYEDSIHDLAQHENEFRDKLASYGINDKTAIDKAADLF
STETLEKMEAEKEKYIDFLTGLGNKQALMEYGPKLLSQEKRQHNSCSLLVIDLDHFKEIN
DSYGHEAGDAALRQITQAIRQSIRQSDFCFRYGGDEFVILITDTDIHQAKIVADKIRQTV
EQTKILLDNQTDDNVTIDATVSIGCIDTKSLPDWSEDKAPITDNAIHNLIHMADQALYKS
KNNGRNQIVNYYDVADDSNQ
>A0A2V3KH76|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNKDFSQTARPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHEPLANKEQVSGLIS
QWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDKWGHAA
GDKVLTEVASRLMAFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNL
HNDHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A8E5TUJ6|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF15034|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N2SLH2|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MKRKLIGKWHAAAFLVFCFVFALTASGVFYNQRGKLAGEYGNMVASNLTSYTQAQKRYLN
SSITDAWNTLKGISGLVEQIVPEYTQDSLNGYLDQLNLQNRDYMIEYVTLQELERRLRVQ
QASERDWSLFGELEQGTGVVSDIWDWKKAGNKSVFTVAEPVWKNGNVIGVLQTRLEPLAI
TEQVPEASAFTRSSTLIVRRDGTILASENHNRGDISTGNLFDSVKVAGITDEVVEQMEEC
FYGDDSDSFMFEGKGDSYYFSWDYLGYNEWYIVNFVRSPDVAIHYDNILKELIYAGLFLI
SLTAVLGCAIVVLFLHYRRSLDFEIKKYGLLAEFSDTALFEYDRRKDVLEFTNNARRILM
LDELKISHIMGKKTRTDLFVQEDRKVMEDMLRGRTGSGEDKIQYAELRLKSISGEYHWFG
CHYKAIASDGGTVVKVVGKLADISRQRSREQELREQAMRDVLTGIYNKAGEKLIDGMVKE
KGQGLFLMLDLNDFKSINDTMGHAAGDAILTEMGRVLKGTCRENDIVARIGGDEFVMFLP
GAFDWQTGKRKIGEIQESLRTVMISAWGIRGIRASIGAALCPEDGLDYETLFKAADEAMY
LDKEQSKNRNESREAGEEKQDRTIS
>A0A2S5GUX9|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MSSSKTALPVWTSGADQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVADSAKELVDAFY
STLLADVEAGPRLSHEIVSTRLHKGMKHWLLGLLCVRDQGDIVALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAERLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITDAVAELDDVVLPRLLMDDGERQLSMPDQVRQLQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIAISSRQSSLFSVLLLDIDHFKAINDA
HGHSGGDHILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGREAALAAAQKLGAEIRR
HAFTIPEAGAQRITASIGVATFDGHPDYAYLIDRADKALYQAKLAGRDRSVAA
>A0A379IRD3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MKPAHWQADLQQIQQLRLFQNVATSSLDQLLREFRACELDAGEVLLSPFNRNQHLYLLIE
GQLRVYLGSLDNQAVSTLEVGDCAGEISFIDNEHPSAYVVAERPSIVLRLHRESLVALFQ
QSPQMMQNLLELLCDRVRKGNRQILDSEQNANVDTLTGCFNRRWLEHVFERESTRCAFNN
EPMSLLMLDVDHFKTYNDQHGHLAGDYALCLVAHTLSSQLRPKDSLIRFGGEEFVILLPE
IAAEAARGIGERLRASLEQIASFYSPVGVLPGVTISIGLAQMQPQDSLQGLIARADAALY
QAKQQGRNCLCG
>A0A3S4UX28|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MTLSVTQLYEVMTQLPDPVFILSEDGYYVEYIGGIEQLSYQDGNPLAGKQLADVLPAAMA
QWVMAQVALALSSGQVQVVEYELAATEVEGIDAAAGPQGTQRFEGKIAPLPSRYEGKRAV
AWVTRNITRQHELQQRLKRLGETDQLTGLYNRHFFFEHYRHKLQGQGRTGLIMLDIDHFK
QINDNFGHQTGDRVLCRFCECVAAQLRVEDLFVRSGGEEFLILLPQIDEAILPKVAERIR
AAVAAMAPDPVPITVSLGSTLIQPGEEVNAVLARADEWLYRAKRSGRNRVAHDPDS
>A0A087ACJ4|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium callitrichos DSM 23973|TrEMBL
MSKPIEANIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKVRPDLIVLDVML
PDIDGFTVTRRIRQEGIDSPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQEEDDPVIRVADLEINEDSHDVTRAGQTIDLSPTEYKLLRYLMDNAGRVLSKP
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVTDENGEKHKVTPLIETKRGIGYMIRE
PKS
>G8AH65|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
METDLLFADDDQPPPPEDGAEPWIVLVADDDPEVHAVTRLALGGLRYKGRRLSLVSALSA
GEAAAVLRCTPNVAIILLDVVMETDDAGLRLVRTIREELNNHAIRIILRTGQPGQAPEED
VVLAYDINDYKSKAELTAKKLFTSVVAALRAYADIVALETNRRGLQQIIQSTDRLFELRC
MQQFAAGVLTQLSAFLRVKPDAILCAQRGAAGRPLPDGAFYVLAGAGCYAEAAGQTASPT
GAVIPPALAERITDAFRSRRSHYGANETTLFIRVPDGHEVAAWIHTDRPLDEVDRGLVEV
FASKIALSFANVSLYERLREANETLEARVAERTRALEAANAKLERLATVDPLTAVWNRRH
FLDLAAAELGRAHRHGRRLSVILLDLDNFKAVNDGHGHAAGDEALRTAVVRAREALRTSD
QIARFGGEEFVALLPETDLAGARIVAERVRAAIAGSPVVTDGRAIPITASLGVAEWSASE
PSIELTLRRADAALYEAKLAGRDRVCAADEPKAPARP
>G8AUF4|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MGHQADQNQSGVGVPGGEACAPAGRPMTASMTVADLPLLDGLWAPVWLHDGGRGRMVWGN
RAALELWNAASLADFQGREFGSQPEGAPQAEGESVAGRWTFYPKGRPVTAWVRRSGMALP
DGRLGILHEAQLAAPLADPDHGGTDTEALDRERAMLQSLIDSMPDIVFFKDVNGTYLKVN
WAMLDYAGRPPLGLTDHRLFDAETAVRRRRTDQIAMQKGFSRSEEWFVHPDGRRVLMETA
KAVCLDRSGKMLGVVGIARDITERRQTEKQLLRQHALLQGIIDTIPDAVFFKDRDGVLRK
ANRAFASWTGRPLEQLIGLDSHEIWPPEMADGIRAGDASVYAEDQPRRNEESIPLPDGGR
IWVEILKAPIRDAGNELLGLVGVGRDITLRKAAEEDLRRSEAEKDHLANHDALTGLPNRR
LLFDRLDVALARSRRSGRSLALLFIDLDGFKAVNDRMGHDCGDEVLRIAAARIAGCLRRS
DTVARVGGDEFTIVLEDVTSAADAGGVAAKIVEAVALPIPVQGRTAVIGASVGIALSPAD
GSDARSLLVAADGAMYRAKQAGRGTHIFYKDISRRNPD
>E2XEL1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLAN
EAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSL
QSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKE
RLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLM
ENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKML
RQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAA
GDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIW
EGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQAAAHSERA
AMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQTFRRSYSD
PALSHALDPGYSTNFSSRPQKRLPVKA
>A0A4U9HBA4|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MNARSYQELLNSKHRLAIFLFLLMNIASSLFTLLMPLKNTPAVTPPLFGIPLFCLAALLF
TLRSPGNYIKRLEFFSCVLGLLWAGHIYMKSQYLLPNVQNYLIISLFSIFFISAITLTDN
VIAFCLHAVPSALTILLLDNQHNTLRILFISVLPIIAFSIHHLMLKRSESFTHALVARLY
EERDKLSNLSMLDPLTGLYNRRGLENKLSLLTTPHNGLHFVLLLDIDRFKAYNDHYGHTM
GDQALVKVACAIRDAVRSRDIVVRYGGEEFLVLLTNVSKEYAAQLAEQIRLRVQALAIPH
GFNQLAATHVTLSAGISPLEQLDVASAIRAADSALYQAKNNGRNSVRLATPPPT
>A0A7Z9BGP6|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MSLNPIFSDKEVIEFPDSPIPLDSKFYIQRLPCEGLAYAEIEKSGSLLRVKAPRKMGKSS
LMLRLMNHAEVLGYRTVLIDFLQTDTAIFENTNKFFRWLCVNIARQLELEPKLTDYWDED
MGSKVSCTLYLESYILPQINQPLFLAFNELNCVFEYNNIIQDFLPLIRFWYEQGRQNKIW
QNLNLVLVQSTEVYVSLNVNQSPFNIGLAIELPAFNLDQVKDLAKRYQINLRADQIQKLT
DLVGGHPYLVHLALYHLGCDLITFEELLQTSATLTGIYRDHLQSLWVILHKKPELAMAMQ
RVATASESIQLEPMIAYQLYSLGLVNLAGNYCASSCELYRLYFGLQLLRNNQDDAVKLKQ
LQQENSLLKALVYIDPLTEVANRRQFDHRIEIEWKRMLREIAPLSLVVCDIDHFKIYNDT
YGHQAGDQCLREVAQAIRSVVQRPGDLVARYGGEEFVLILPQTDAKGALYIAEAVRQKIK
ALALPFKTEKLPARHESVSISLGVASTIPGVDAGDIGTLFLAADEALYESKNNGRDQVKL
SSFLQFQY
>B2AIA2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1)|TrEMBL
MTRLLPTLHRLSGHAWQLLASRPHRFVVASFSLSVMLLVLLLWRGLQLSQDREIETLRHM
QAVRAQSMDALLQREAERLLGVRNFAEHLLQIQASTPGRPDAALRATLARRDEPVWPVPA
HDAAAVYGVGAAALSGLEGFERNEARLAADVDVARSLSHLLSAAPQESGIRRRIAYVSRN
GVLTAYPSIPPQQVAPAVHRLAAAPYFHDSLPARNPGRQVQWRIAPATSERDQVSLFLSV
PVYAGSDLRGVAILELPQRSLDDQLSAAPFPDASSYLVDREGRLIGASARNVRAGETMQA
ALSGPWPAATLDAVFHADAGLLTSVSGGGNDLMFRRLRNGGLAMVDEIPVNQLWLAGAAR
LSGVIGAGAAALGILLCATLAVVHSLFRHYLARGEALRTLAETDALTGLANRRVFAARFA
AEAARCAAEQRPIAVVMLDIDHFKAINDRWGHASGDVVLRAVAAALRSGVRKDDLPARLG
GEEFAVLLPGTGVDDAAAVAGNLRQRLERLRCDPAADALCNEPMRFTASFGVAGSAPGVP
GSLDALLMAADRRLYAAKANGRNQVVAHESGNVASHHRNLKGL
>A0A086Z034|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium actinocoloniiforme DSM 22766|TrEMBL
MMKNTSRYAAATTILVVEDEPTLATAIAQRVTAEGWTARVASDGASAVQAASQFKPDLVI
MDIMLPVMDGLEATKRIVAERPVPVLILTARDDEADKVTGLGAGADDYMTKPFSMRELIA
RCKALLRRVERAKVIAKNSENEKLLDFGSLVIDPAQRIVSQNGEQVHLTPTEFDLLATLA
RKPKSVLTREKLLEEVWDWVDASGTRTVDSHVKALRHKLGAQLIRTVHGVGYAFEPPEDN
GERGRS
>A0A8B3W7R7|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLFDKFSSEGMQKNIDVDTWVSILDNIRDIMDASNAGIIMISDLSCSGSESVWSSSNISC
NQHKSKISLFCEYVHNENRTVYLSGHAGGDSVSANGADAYKSFCGVPVRDIDGEVFAVLL
VFDLSPTAYTESQVSLIENISTLLRSEILLKEESRILYKNSHFDIMTTLLNRRGFFHEFN
KANISDGEVVCLYFDLDNLKYINDTYGHFKGDDYISGFASCIKNNSKYNIISARVGGDEF
IVVIHSEEAGYASELVNNIHAEFDDFIEGFRCDDEVPLGFSYGCGTADSRSFNIINLIKS
SDENMYLNKKNKI
>A0A174QTG1|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MGGRRWRGRIGILFTVLFCLLLFSFTARAAENGSRVVRVGYPVQQGFTEISEDGTYSGYT
YEYLQEIARYTNWEYEFVTVEGSLDEQLSGLLTMLRDGEIDLLGAMNYSERLAELFDYPE
YSYGTAHKTISVLKDNLEYTEFDYDSFDDIRVAVVSFDGQEDEKLNGFADMNGFRVNQVL
CSTGEEQMELLKTGKADAVLSMDVSLSDRELRVISRFDSRPFYFGVTKGNQAVAGELNKA
MEIITSTNPFMTAELNRKYFTGEDGLVLSNSEREYISRRGTVRAGVMLGRAPLQYQAKNG
EIRGISIEVLKYIEEQTGLSYEIVPFHNWEEYSRAMEDGAVDLVVGIAGDYEVTGAESCA
LTLSYLSVPLQLIMNENVKALADLSGKKLALQKSLLTEQSLQGELHYYDNVEECMEAVHK
GEADYCYGNSYAVQYYMADHNYKNLFTFAQSENWTQKYCFGIRRPVDITLLSIMNKVIRV
LPEEQVNRFLYQNAYDAGNLTFSEYVMRNPEQSILYLVLFWLLVVTAVLITAEILRRRNM
ARKALENQRYEQLSQLSNEFLYEYNIREGCLNLTEQTAGFLGCEKKIRRPEALKQKYPVF
GYMISQEENHTEHECLLPGGNVRWLKVISKMVTDTSGRPWYAVGKLVDIQTEREIKEQLE
AKAQTDSLTGVYNSATSHQRMRQALMAEGRDGSGAMIIMDIDYFKQINDYLGHYTGDQVL
KETAGILKACFRADDIVGRLGGDEFVVFLMEVNDPDLVKQRCTEVLDRVKNVTMEKHGQE
VTLSIGAAMAGGETDYDVLYRKADQALYQIKKNGRSGVLVVE
>A0A6N3CPS0|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEAEDCFCGGFLVVNLISIAFLAVREKAAVNQKLFDQAAETEAQFGGIMETYERSFQLFA
HMMAREIEHEPDPDSVRTYLKGMDASLFNIVGETYDGLYMYYKGQYLYSWDTPYSVYEDS
GYVVTERPWYQDAVAGKGEIVFTPPYMSYANHYILTTISQLQADGETVFAYDIKMEDIQN
LVSSMEQFEQKQILIYDGAGTVVGSTVPGYLGGNLQISLEEAAQNLEDAQAELDALKKDS
GAETAGAEDTDRAEDAAGAEDTAKSEEIAKAEEKRDSAAAFLEFRQRLSEWVRASGDLSG
SAKPVTMDGNRYYLYNHQTAGCGLMVLVPEVAMLKATVGTWLVPFLVMELILIYVLGSVG
RELRNQELRAAYVKMGQIQKRLELALSAAQKAAAVDDLTGLMNFKSFQKEVGEQLDTMDE
KDSGILIMIDGDHFKRVNDNYGHSVGDEVIRLSAQMIIGRIRTVDLASRLHGDEFAIFVS
NTDNYDVARTIMEDINASIAKEAGKRNMPAITLSAGAVTARRGGRYTELFKAADEALYQA
KKTHNGGFASFEEL
>A0A8F6AHN8|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MIKIDNKHLKFSLLLGLLGLLINLYPLPLFGNVQLVLGNFVFIIVAILLGPWYALITAII
SSIGLYISWSSPHVFILFCLEAIWLGFARRRDIYSLYADIGYWLAIGMPLFLLYISMFST
LPESHLSFTTLKQGINGLFCAAIGSLAVTVFAELWYMKGKVKDRKRRSFNSQLTYSFALV
LTISLLGSALIFNHQVITKQQESLQRNLHDSVTHLGQATEVFLETHKQAISNASQWLSLS
SHEVYDWQSKLIRLHNSYPGFKTMLVTDADARIIAASPLSQLGADKVANKLLSVKDRHYF
QEAFFNQRVYTSPAFLGRGFGTDPIVAISAPIYQHNKLEQATGIIEGSLDLSTFAQVDNS
NKVYQDQSMVIVDETDRVIYASAQLGLEPLSQFKWVESGKDYKTNLSMINLHDTENPNPE
FIYDHYPLNNDWTLYVVKPFSPLLELLQSQYLTTFAVLILSLIITIVVTRVLSVRLTQPL
TVIANKFAENGQTKVTDFQINEESPMEFLTLYQSIRKSKQELISYQLELEEKVAIRTFEL
EKANSKLQTLVEKDELTSLYNRRYAQSKFRSTQDFCQRSDEVLALAILDIDNFKSINDTY
GHQGGDECLRVLAKEMKKYFKRDTDVVARYGGEEFLLILPFCNVLMIEEHLNDFKNKIKC
LRIDNPHDQRQISMTVSIGALINNANFSTQLDEWFKQADLNLYQAKHQGRNKVVISMPLP
LKLKDAGHPD
>A0A174XRG0|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEKKRAGSDGSCRSAVMYFVMAFSFCLFLWIFITGKAPDVRFDSEQSAAVTGEWKIEYQG
QEVQSELPGPFSPQKEELIRYSTELGDYGIKGNSVMLRAVHQYVRIYLEGELIEEFGYNQ
ETPFGNAPYNAWVIARLPENWQGKTLSIETVKYYNGLSGQLGRVYIGTKNALVFQVIHEC
MPTLIFNSAIILAALLLLIYSFSFQKKYITYQLRCLCIFSLVTCMWLILESGGYQILWGK
APLVSNALFLLFYLIPPACIQFILTYESFSEDRWMNLLFWLANLNFIVVSILQITGISDF
IESLIGAHVILLLVMAELLFRFIMRILRRDPVKDIQLMAACLSFALFACLDIVRFYVGGT
DISSAYFSQIGVVIFFSVLIYYAVRQLVLERDEGMKRELLEHMAYTDMLTALPNRNAFEK
QMALLRGESGPGTMVVVADLNELKRINDQWGHQKGDAALIFVAAALKSSLEDCSGLYRIG
GDEFCILSDRISGKEAKAFEERLEEKLGEAENELGFPVSVAVGWAEEDECGIDLAFRRAD
FTMYEKKQQMKRKRKQEELRSEPPECGCGGIKNETE
>A0A379HEW4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MMFHDSMAVAQDKMTKVCVFLERHVLPPTPLNYQVVYTYISQVNNDLNSAIERAIASNTL
IDSLFTEQLYFEHLNQGHATEVSMIENVNGVINSLSKSAQHTEKQFINFAGHISECMHSL
DENNIKNSRIALTRLDQQTATLLTQHKQFKQQLSNAKQLHEKTKKQLNTLRKQHIIDSQT
GLYKRHYLTKQVQIWANQHKPVCAIAIQIDNLDHFIDNFGDVIAEAILSKVAKQVQKYVF
QSGLAGRTAKDQFTVLLTDVDCETTNLIAEKVRAGVAKLRFISSKNALALPAIKLSLGIA
QQQQADFEQLTKSASNAAFKARSLGQNSFTAEH
>A0A202FAS3|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MRTVVEVVQTVLAKNDKSIKLYRTGGEEFNIIFPHYHVKETQAIVKEIFEAVNHTEVDVD
KNKIHITISVGVSEISKKDVSVNDFYSRVDKALYHSKRNGRKEITII
>A0A5P9I470|diguanylate cyclase|EC 2.7.7.65|Roseovarius sp. THAF9|TrEMBL
MRTGAIDTLVALLDVLCPMHLILDAMGRITHAGPTAAKVLDSKALTGRDFFDLFEVRRPR
LDPGVPGLCAVAGRRLHFVLRGPAETELKGVAVPLPEDRALGPPGGVIVDLSFGIGVIDA
VGRHDLRSADFAVTDLAVEMLYLAEAKAVVTDAWQTLNQRLQGAKAVAEQEAYTDTLTGL
LNRRALDPVMRRLIAGGQEFALMHLDLDYFKSVNDTLGHAAGDHVLRRVAQILLEETRDG
DTVIRTGGDEFVLIFAERTSEAELSRLTGRLIRRLEAPIAFNGEVARISGSIGTTRSSSY
ATPRLAVMMDDADLALYAAKQAGRGRHVAFTSALRDAVEMRSVGAVPPV
>A0A2X2CR33|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MAIELDDLHWMLDIVQHIDVGVLVINRKYEVEVWNSFMENHSGIVPSDAQGKLLFSLFPE
MDEDWFRYKVEGVAMLGTPMFTIWEQRPYLVKFKNYQPITGLEDYMYQNVTILPLRDTRG
GVGYIGIIIYDVTRVATNTRQLQSVNGQLEQLSRTDRLTGLFNRGFWDECLKHEFARHLR
YRCNVGLVILDIDHFKKINDTYGHPGGDKVIQALANLINGHIRATDRAGRYGGEEFVILM
PDTPCSGAQIFAERLRQQAEQLKVEHEGKQIAFTISLGIADLSLPVESHEVLLERADQAL
YQSKHNGRNQVTVYSGA
>A0A1G4YH00|diguanylate cyclase|EC 2.7.7.65|Kosakonia sacchari|TrEMBL
MRQNRVVKQPRSFKQLQRYFVPAQVVNLCFVIVMVCSTLLTWREVIVLQGAYVASQRSAL
ENVSNALDMQIQVGVDRLLFFRNGMQAALQKPLGFEALNSVQGEFDRKRALPYWQIGLDN
SRTLPIYGVSDSLVEQSGLLRRDEERLHDELMAAMELGYLFRLSSEAAMLPRQAYYFSRA
GFFLSTRAVDREQDIISTYYRLLTRPWFSSQQQQENRARGVRWFTLLTNPENNSFVAASV
PLDYQHYWYGVLVMSFPLSAIKPLLIDEQLQQDGGEYQLYDNHFRLLISTQPLQNASGEF
NQDEIAKLQADMAHDTVGGLHLGTRYVSWQKLKHFGGVLLRVHTLREGLSGDFGRISIAL
SLLWVLFTGMLLFSWVVIRRMVTNLYSMQHTLQWQAWFDPLTRLYNRGSFFEQAKVLSEE
ARAQERPFAIIQLDIDHFKGVNDQFGHQAGDLVLSHAAGLISSSIREQDVAGRVGGEEFC
VLLPDSTLEQAVQVAEHIRSRIESKEILIHKRTTLRITVSLGVSAAQESGNYDFEYLQSI
ADSRLYLAKNSGRNQVCSVDVIPNR
>M7NHU6|diguanylate cyclase|EC 2.7.7.65|Bhargavaea cecembensis DSE10|TrEMBL
MRWKGRLIAAGIVVLFNIMRYFYYHVYLDVPFDGSFFLLTAVFLAIAYAGGYQYDRADYL
SRRDPLTGAYNRRFLIDYVRKLRLSGHPRYGVVLFDLDDFKEINDTYGHEAGDAVLRDFA
ETLSDFVGNRGIIARWGGDEFLAIFREADDEFKMYAAEEISARMNTLGYAGGRSIGVSFG
IAVASSEGEDLESLVDAADHAMYVNKTGRKSQV
>A0A649YW22|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MKEPDFPDNEAQRIKDLHSLDILDTEPEERFDRVTRIAKHLFDVPIAVVSLVDNHRQWFK
SCIGLPVRETARNVSFCGHVINDDGPFIINDATKDPRFLDNPLVMGEPFIRFYAGVPLVY
HNQSKLGTLCIIDTKPRELTMQQMADLVDLAKVAEQELEATIQATLDPLTQISNRRGFFE
LSEKSMDYCRMGGFCVALAYFDLNDFKAINDKLGHKAGDEALQKFADLMASSFSDSDVFA
RIGGDEFVVFMSGLTEKVAEIAVKRFRKSVERFNDEENRGYEIKFSVGIVVAKPSSDMSI
DSLLEEADKRMYQEKCASK
>A0A7X5JMP9|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MSKQFQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGGSLNYTYTTINIIEAVAGAMLLRKLLPWYNPLQN
LNDWARLALGSAVIPPLLGGVLMWLLLPEGTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVLMVSLMLAANPSLLYTPKANVMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNNDL
EQLGMLVRGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPLHIKPSWQVWYECVV
PEDREHAENVIRDSLAARIPFKLEFRIAVRDGVRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDDAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHNTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
SGRIISAINEYQFRWEGRLHRIGASAGITLIDEKNHVATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQTHASRELLSFDEQKHIIAHNPMLMIARGVASPRIPETFSFWLLSLRLGTED
GDVIEEHIFRTGLVDPTLNHALDRRVFNEFFQHAATAIASKGLSIALPLSAAGLLSTELV
DELLAQLQHSPLPPRLLHLTIPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVE
NLKFHTVDYLLLDSEISASVHGNLMDEMWVSIIQGHAQQLDIKTIAGPVQMPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A517ZCV3|diguanylate cyclase|EC 2.7.7.65|Maioricimonas rarisocia|TrEMBL
MDSSRVLASLLQLAGHAEDSDGGPDGQVASPDVLRSLLWALDFRDRATLNHSGRVALLAV
GMAQQLGWEGRALRVLEVAALLHDIGKIGVPDHVLHKPGPLSVDETELVAAHHSTGVALL
QACRIDRQVIECVGCAHGQTLDVTAPTNSIPLGSRILAVADAYDSLSHDQSYRQGLPHEK
IISTLLEQPAQRFDRNLIHALARWIEKDGLRSLTRDADPAVSQATESPAAEWEDFEITRQ
ANLLCHLFSYLHLLGSLYDGFYILDASDQFVIWSRGAESLLKRPSGSVLGKRRLNEHLNY
VDGRGLPIPPEALPHKLAQATGEQQCSMLRAKLPDGEILHLEVQALPLLGDDGALLGVAE
IIHVPDRSRRQPELYRELQRAASTDALTGMANRAELESRLRTIAENFEDGKSSGPYSVIF
VDLDHFKQINDTFSHAVGDRVLVETAALLQDELYSGEVVGRYGGEEFVILCPDTDLDAAY
RRAERLRKALLRSNVGGQPGLEVSASFGVAQAEPGDTAESVRHRADEALFEAKEAGRNRT
CTRTSGSTTPAPVAAPAVAETPEESALRYTTEFQVRSDSELLFHKLRAFVSETQARLRDA
DDSQMRLLFGRPGPLGRWGSAPAKCAVELTVKLVAADPSAPKSRRCVTVAVTITPEGWGF
DADRFRRRAAQVANELRSYLLAE
>I6CPS2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MENQSWLKKIARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>I6CQJ1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDTSVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRICLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAIDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKE
>I6CVE2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCVMLVDINQFK
RINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQAKIIADRIR
KNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKSEGGNKVIIH
HI
>A0A506Q117|diguanylate cyclase|EC 2.7.7.65|Pantoea deleyi|TrEMBL
MTEILSPQNNIPNRWLQALVLGGVLFFLTLFCLELIVVSGKISPLWFPTTLMTVVVFRCP
TRQLPLLLAACVLGTASANALVIGPAFSNLKFTLLNLIQAGVGGMLLRALLNRRAPLDSL
SDWARLVLSVGIMTPLLGGLLAIWTLQVSGEALFPFFYTWVISEIIGMLVLGPMLLLLPW
PLRRAQFSDLRLAELALTLLLTLGASYLSLRFLPWPFTFIVVILFWCAVRLPKLQAFILF
FLNASFISMLLALDLVSVVNNNSSLGPVSSWLPFLLVLIPSHIMSLVMDASRREKLHISD
SETRFRHAMEYSAIGMALVAPQGNWLQVNRSLCQILGYPADELKRLTFQQITHPDDLSLN
MQHVRRLLEGDIDTYTLEKRYFRKDGEIVWARLTVSLVRDSSHAPLYFIAQIIDISELKQ
SEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYDLFGLAPHESPSYDLWIHLL
HATDREYAALTVQQAIETRSAFHMEYRVVDRQGQRWVRTQANRLLSKEGRIERMLGICQD
ITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMCVAFMNPVAEKMSGWSQAQATGQP
LSKVLHITQGRNGPEVENLLLCQLPPEKVAPDFAEDLVLHAPDGGHIDIHYSITPLRSEA
GLEQGAVMIIQDVSESRKLMKRLSYSALHDTLTSLPNRASFELQLKRLLFDAAEHRHHHV
LVFIDLDKFKAVNDSAGHAAGDALLRELSALMQHHLRSSDFLARLGGDEFALLMPDCEVA
QAHDVVQRIVAAVNDYRFQWLGRLYQVGASAGVTQISAENCQSSDVLSQADIACYNAKRS
GRGRLMIYEQHRLPLPGNHQGLDAGMIDALQIELPAWAVAPPKTPQAAFVWLLDVQLLTA
DGLLMDETLLRSNLADETLRRRLDNNILDAFFRHTVQVLNQKGIPVILPLNAQVLNDAAF
MQQLCQRVVAAGMADSRGGFAFPAASVIGKGDQVYAALRQLRQCGCRIVLQQFGRNLDAF
HLLSDDVVDYLVLAPDLVANVHTNLMDEMLLTIIQGQASQRHISVLAGPVSVPAMLNTLA
TLDVDGVWGSAVAERQPLRSLAEDRIFAIR
>A0A737B785|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7U9R4H8|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKKVYLYQASLGAEKEKNLGEITMGYEAIPYEKRIKDNIRNYSLSNLYDMEMIKKYLINL
ADLLEINVLLIDRHGEKEIVVGDGFLGFHPQVEQEPGRKIRVQNRTIGHLYIKELSKNRD
ERLIGEMVDGTVTLLERLGEEVYLHREGSIYMEELENQLADKKHKISQDEREDILTGVYN
KIYFESRMKIIDRSEVVPVAVINVNINDWKFANDHFGDEESDRLIKIVADILKEEAKPYF
VTGRVDGDVFGVLIPMAGDGEAEAFAARIQDRCNSYEDARLAPSVAVGIVYKTNIEELLE
DRLSDAEYEMFNNKFDVKNAPGYRERLKKGINT
>A0A8F8C6W9|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MLRSMVLLAMIAVLLVGAGTAAWMAYSMRQVVLDGVLPAHTKALEYSARSLVFRVEQQQK
PLQSLAALLSEHMQDSPEAMEVMLRQQAFWGQQFEQVQLANAKGQLLLNLHKQQAKPLHQ
LDESQRDVLKRAMAAGKPMTQAWVRPSDAGLKLEFYNVVPLRNAQSKLVGVLGGSYTVPL
AMLFSLESDSSNTGSQLLLVDREFKPLAISVKAEWQIPAAANVAALSKELEPAWINTAQA
GAVSEQRNNKIISAMPLPWAQWTLLKVSDVQDWAPGISFTKMGWLAAALLVAALVLGAVL
CLIAYPLTALYRTVEWAGHRGLMLEVDSSVRGAHWWQALSAHDWGEAQTLRTALQALGGG
YEVHGERERQLELQLQTLMDYAPVGSIVTHGLKVQRVGLQAARVLGYQPREMLDLPIRDL
CATDADFISLTQRVHRELETYGKFNSEVCLMRKDLSPIWVRIHGQSMRRMSMNTDRGPAV
QESDEPYLVWELEDASAQRQLREQSRWKAMHDPLTRLPNREAFVLHLQEWLGEYHSTGDH
GGSDASSVLSAAKAASLTSADPAMHGVVLYVDIDHFSQVNRQGGREVGDEVLGHIARLIE
ATVRPHGWVARVGGDEFGILMAGVGREEGMRQAQLLCMAIQDWDGNYQGQRYTLSASIGM
LLLDASYHTGESAFKSVDMACYVAKRKGRNRVEVMAAAV
>A0A6J4F3N0|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MMAGADDNIIDLASERRRRGPRFNGGLMDILEVSRDLVCLCRGGGITAINGAGVRMLGGR
VSEDLLGRQMADFLIPEYGPVMELFFAGMSSEDKPVPTRIVAIDGSLTDVEMQVFRAREI
DKDATVVMCRDISHEGRLASHAQERDTRFHLLVDNAMNLVCHTFGGVVRYINRAGVEMLG
ALEPEAVIGRPLAELFHADYAELFAGGMLESVVAEGVPVPLRLRRLDGEAVDAVVKMVQL
SSRGGGELMVEARDITAHNRAVNALRRANETLEIRVIARTRELAAQRARAEEHRQAAEHA
RRFTENLIDTIPSPVWFKDARGKVQTTNRAFRDLFGCETGRLAQCEQALAAAMPEEDAVS
DLELLSGSRTHAEFEASIQVPGQGSGCRRLDGLFLKTAFLDDDGRVVGVIGIMTDITERK
GMERELRRLATTDPLTGAFNRRHFMAAANAELERAGRYGGEVSILMLDIDHFKAINDRFG
HAAGDAALKALVAGCRDWLRDVDVLGRMGGEEFAILLPETAMEAAREVAERLRQRIAELR
VASGADTVAFTSSLGVAGARLGETGVEAVLARADEALYRAKSGGRNRVEIG
>A0A8F8DC07|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5C0WHL6|diguanylate cyclase|EC 2.7.7.65|Bacillus safensis|TrEMBL
MDSIVLHFIVIMSVSGILSVILSIIAHANRHRYIGCQLFMYMSGATAIYIFGHTFELLAR
TPGEIMFWVCFQYIGLPFIAPLSLLIVLQFTGFHQYLTKRRVLLILLIPTLTTIMVFTNS
LHSLFYRSITMNPVDGFLLADFTIGYWYIIHGVYTFGCSMLAIFMLFWFLRVTKKEYLKQ
ILILLVGMSLPILTSFIYLLGVTPLHIDPVPVVMFITNALYLWAIMSFQLFKLSPIAMER
VFEHMSEGVLILDRYRTLIDYNPAAASIIPALANKKGIGYKIDDIFSAIIKDSTFIQWLR
SPQDHSQYDLMWKKEKDQSCYYHLTASSLFNRRGEIEGRQIVISDVTEQRLLQEELERRA
YIDGLTNIFNRSSFIERTQMILEEDAQDTAVMLFDIDFFKQINDTHGHHIGDEALRHVVS
ICQEHLQMDDLFGRYGGEEFAICLPHQSFKEACHIAEKIRHSFEASFFTNDEEKVRVTAS
FGIAHTANDPCVLETLLFEADQALYMSKRQGRNRIYASTGKGHVLYQEQDLLN
>A0A1V5JS86|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin520|TrEMBL
MDIELGTGMDGGEAARQIQEEREIPVVFLSAHTDAPTIDRTRVTSHYGYVVKGTGDALLQ
ATLETALALFEARSRLRESEARYRLLIENTHDIIYALDPEGVFTYVSPSWTKIVGHAPEE
VVGTSYKKHVHPEDQEACHVFFKKFLDGASSLSGVEYRVLRQDGQWAWHTSSATAARDGE
GRMTSFIGIARDISERKVLEEALRHQATHDTLTGLPNRTLFLDRLEHELAVTKRRGRGGA
LIFLDLDNFKNINDTLGHDVGDQLLVAVARRLKALVREADTVARMGGDEFTLLLPEAGGA
PQVADVARRICQALHEIFVLDGKELFISASLGISLYPDDGTSVTTLLKLADMAMYRAKAA
GRSTYRFWSGPDPTPPEAR
>A0A5E0ZTX5|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MNNITLAEKMIMLSGAFLFALMIAVNSFCVNDNPGFRVPMTTYLIVMIALFFLDTIIFIF
IQMQYASDRTHLSSLILSMAFLSGLVYFIETIVIIQYPEHAGFSNAVKTNDTAVFYFFRQ
LSFIFLLALAVRVEKITTRSSSRQINKFSLALTLFIPLVVLPVLAHYMSSYHPALSLTIA
ADGRDQHAPVWDVRYVNVLITLWSFLLCYMTYVTRLSSGMWNSIIVVCLSAIIYNFFLLL
LDTYNMSLWYISRTVEVFSKLFVIFTLLFQVFSTLKIFGDRINRDPLTQIFNRKYFYEAL
QRNRMLRTEKGTSIMMLDIDNFKSINDTWGHPVGDRVLLAVVDIIKDCIRDKDIFARLGG
EEFGLLLPNTDESLAVSVAERIRHNVQHRTGQGNLYALPAEVTLSIGVCSAIQSNLNSTD
IIRNVDEALYEAKHNGKNRIVSRHAECG
>A0A7W9U6E2|diguanylate cyclase|EC 2.7.7.65|Massilia aurea|TrEMBL
MARILIIEDNPANIELMSFLLSAYGHAPLSAADGPRGVAAARSERPDLIACDVNLPGMDG
FAVLAELKGDPALAGVPILAVTALAMTGDREKVLAAGFDGYISKPIEPESFVAELEAFLT
STPAPASAPAAPAAPAAAATAPVTAMAANDATANDAMATAVTPATGARTLLLVDDDRFML
GVLNDMLIGQPYRVLSACSGEEALQVLSHEPVEVILCDQAMPGMRGTEVLAEAAARYPKT
VRLMLSGQPDLTDIEAAIKSGVADGHYIKPLGARALREQLDEAFRLQSARGTG
>A0A4P6LZF3|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MAMKEHPEKTGKLLGVLGTCCLIFIILVSSIFAVQQKKLNEEYDTLIGNNLSAYTKNQKR
QLNGKISDILNTMSAIAAVMDTNGLSAEEEWFAPFLNRIGDKNKGYHLEYLDMDEIRKEL
EKGECWFTEQKVYQQLLQKGSTVSDHFCVDEKGKYYFAVGIPVSQGGRVTGILQTEIPAT
ILTSVTQESKMYKKVRTFIATRDGEIAYSRIPDFTTDSSLFGILEERGISSEDEKKVRDM
LENSKNTEITDKILLGGLHFYVSVEKMDYNGWYIANFVSEEDVLVSSRAVYRNVLLTGML
LIILTMAAVCAGFAVLRRQQRERVLEQKRFAALAQFSDTALFEYFCGRDVLEFTNNARSM
LGLDTLRFEKFSHTIDKGLIHPDDREMVYNTLKEMPHSLDTRSIQLRVKGKEGRYYWYSC
HLKAIFNGKAKDSVVVGKLQDITDIKQREQRLVEISERDVLTNTYNKSAVGKISQSLKEN
TAGVLFMIDLDDFKSINDKWGHEVGDIVLRKVGEVLNKTFRSDDLVVRMGGDEFAVFLQG
KVDSELAKKKADMILEEIRNIQVEGVGKPVSASIGVAISPRDGATFPQLYRAADTAMYRV
KKSDKDGFCISR
>A0A4P6M501|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MKKDKTAPGSFKKIYRVDLQVFLMTAIIVVISCGITFVVSYCLTYNGMIRALRSRANSIY
EYADGRLDVETFRGLNSRADGTSYLYQEAKKTLENVRTATGVRYLYTAKEKEDGTFIYLV
DGLPVKSKDFRYIGDAIEPECIPDMKIAMENQVVLPKKIKHTSWGNVFIAYFPMHDEDRV
VGVLGIEFDASDQYRTFSNMQLAAPVIICVFCIITAVIAVMLFRRISNPAYQDMANTDLL
TGLKNRNAFEVDIHNLETVKVKSGFAFVSVDLDGLKRINDTFGHAAGDKYIQAGCKILKS
CLPKQATLYRTGGDEFTIILKEVPREHILEMIEKSCRRRRVDGLPADTEIQMSAGYAFYD
EKTDASLEDTYKRADAQMYEQKKEKYRDKIFIGGIL
>A0A7U9N291|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MLLKTSAVCLLMVIYMLVFYYRKPHIPVKSTRIFQALTVAALLNTLFDLITVYTVNHRDR
IPDRVNLVAHIIYLLSILGFVFLLFLYMRSYLEVSMAFSRARKICHQIPFWVSVLGILVL
PITYEHGYTTDYSLGPKAYALYFSLVFYLLLILYSCLRHWERLDGEKRLALILAVPIFAA
VSIIQMLFPEILLVVVASTLILLGLILSHENTEKYLDEQTALFNQYSFETVLEQMGPDKQ
RSSIAAFCFCKTENNFDWKQDVRILQDLRRGLRLYRLRGYRIGENGVAFIAGSRERAQMV
LEEVRNMVLEKYGEENLILETKILPEDMQSRHDRMRSLIAFCTETGYRFAFIDYLTHIYN
RNAFERDLTDASECGSDYYIIADLNDLKMVNDTIGHSAGDELLQCFARLLVDAAGDAGKV
YRQGGDEFAVLYKGDPSRFVRKLEEHCGICNQARNVPVSYAIGYCELSAPDFLEVADRRM
YQDKSRIKKQRNSMQAEEA
>A0A5B8QV38|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MISYLFQCEQEIPHLQHCLRYLAILILLLIVPLTLAAEEKTQVDQIFALFDSGEAIPRET
IEQNLALLEKLISSDDSLRIEKLNQLKCWNQPSDTEEEIAKALHSAEQALANITATASAH
YITDITLCHSWFLQLTGDISGAMQGYTKSVKSAYENEDIKLIADARSLRGALHSYIGDFS
EALDDLVTAQGLYESLNLTGWANVNLSDIATSFRRYGDPESAIKYYSKLKELYVKNGNKE
QVANVTSDIGIALDEMGEHEQAIENFRSSYQYFKEHNLNLIAAINATNIAYSLIQLNRLN
EAETYLKEAAQEITENEPAAYSFLKLFLGKIRFQQGRYQEALDELSASENAFRVMHNDRG
LIQLLQLKSDIYASLGDLPQAYNTLQQFVVITKKVDDNTSAHQTTELKVKFDTSWIESEN
KRLIDSQKLKEQELALLEKNKSLQLIILLLTGCILAIVSLFAYKQVHRNRHLQTIALTDY
LTQLPNRRHIYAQAELYFQQALKQQAPLSVIIFDADHFKKINDNFGHEIGDQALLTIAEA
CQALTADRNLIGRIGGEEFLILLPNTDANRVWQLAHELQTLITRYGAINLPVELKLTVSA
GVATLHPELGKQDDSFARLLKRADNALYEAKNAGRNCVKAAEAIA
>A0A1S7MYJ0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum S56|TrEMBL
MIETIDTNIFNLAPVAMWIEDFSEVKSQFDIWRAQGVEDIRAFLLEDLSRVAACSQKIRV
VQVNAKTLELFEARDKAHLIDNLHRIFRDDMLESHVNELSELWAGKTEFISNAVNYSIGG
KRLDIQLRGAVIPGYEQTLGRLLLTTEDVTEREEARRKELFNRRYAEGMFQHSPVSLWVE
DFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLNHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEMNRLERSTIRPVSAIVIDLN
GLKDANDKLGHDAGDALLRRLGEVLNGVVTAPNHAARIGGDEFAILLPGADKQIAAAMVD
TIYELLKINNQFYSNAPLSLSLGVATSEAGETMESLVRRADMHMYEQKNAYYAAMRNRSA
DNSDTTKASPQTEASSLKRLL
>A0A517TNJ2|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium MalM25|TrEMBL
MPTPSPTTTPADPPAESAPTVEASGPERISELLRAVDEAAATTGQGSPAQLAEAGAAQQK
LVGWRLGIVSSLFVALRCKHPATADHSLRVAIGCSAWAGALKMPEKLRTQLEVAALLHDI
GKIGVPDAILLKPGRLTDQELQLIDSSREASRHILRSAGMPAEVIDGVAAASAWFNGTHR
SVTLTGDQTPFLSRMIAIVDAFDSMTTDQVYRPARSRERAIATLFEQGGTQFDPELVASY
HESFAQDQRKLDEEIAQRWLSTLGADEPPLPWTPPAPATPQAGPAETTGSPFSARLIENM
HDAVIFVDARNVVTDWNTGAERMTGVGASAAIGKKLTPELLDMAKPEGDLLEESDCLITR
SISEGQQAIERLSILGRNGQRVSVETHIIPVGAPESPSQIIGASVLMRDVSDQTTLEERC
QALRAEMTKDPMTQVANRREFDRMLAAFVEAHLDTDLRCSLIMADIDHFKHINDNFGHQA
GDEAIMTFASLMKSLCRSGDLVARYGGEEFAILCADCNNATAAQRAEIIRKKLSETPHSY
LGGKHITASFGVTELQPGDTPETLLRRSDRALLRAKDQGRNQVVQLGDGMQEPETTKGGW
WDSLKRLVSPITRGGSLIEARLVTNVPIELAVDKLRGFIADRDAQILKTSENYLRLMTEV
RGAGGNRRASDQPVDFIVDLELAQEHIERSNSSGLASGKYVQTNIDIKIQPRRDRDRRQS
RIIDRARQLQSSLQSYLMAKEIDAEPALA
>A0A128FEI9|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MINSLNPILNLGITRCDKLQVHHLRMVNLLTCLCAGGTLLFSALFWFAFGSATAALLNGL
FAMLYLISFVLTREGILWMAKYWIFVTFFLQQLFLPLFVLSANFETELLLLVVPTAVVLV
FDPNERLPRYGLSLIAIFLLFLAKTVPSADPVLALTDTNARAAYLCVILILVLASVALTD
FYLVDLHSIDESSRKLVHEDLLTETANSQSLYNQADELFFQAQRRGEPLSIIAINLDDFR
QINEMHGRPTGDQVLVHIADLLREQLPPATPIGRLYADNFAVLLRNTPSNEAMRVAEQLK
LAIGRSVVLLDNTAVKRTASLGVTTSNEGCLAGFQLIDTAILAVQNAKKRGKNKIQTLSP
KGINALYRNEHYQPS
>A0A731N8N7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:r:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A518I8B8|diguanylate cyclase|EC 2.7.7.65|Gimesia fumaroli|TrEMBL
MMTTLLVSMISLTNDVLILFGAGLLIAVSLGFTAGYFFGKTAPARHLRRAKKHIQGCYQH
VKEALDTAQAACSMLEKFPGMVLTNEQSSELNKKRSNLLELITRLVDRKNSDQDQAKIES
KTDKKKKQKFPAMQWALEPEHVHLKLPDTSAFEANMEMLLLGSTSSEQTCGLLLVQINQY
DQLKERFGIMAPVKFMKTISRLVLHKIRDEDVICVWKSDTLAILFPGYSLDEGQANAENI
REAIRHHHFRLEATSPEVVVTASLAYINCVPGDSAELVLERGSHALAKSQKKGRNQLIIQ
DSHSYEHKAAV
>A0A564SZP6|diguanylate cyclase|EC 2.7.7.65|Dorea longicatena|TrEMBL
MNGYFCVLTTIDFFVLCFMCILTYLSETLSKKQKRGFFLAFVLIAGISVLEVITLVVDGL
PSGYRWLNITANYLGFGLSPAVCICLVYVLDRKTALRREIRTAVRIEIGYLIFLFVTIPC
GMVFSVSADNIYSRGPHFYIYVVMYYGAILYLSASTVITAREFQNRSRLLIYPLILFVMA
ETIIQVALPELHVTWLCVTLLSVLYFIYCSEMWNQLDALTGLLNQNSYLKQTGGVRCKGG
VLVVFDVDDFKQINDRYGHIQGDRCLAGIAECIKKFYANFGYCYRIGGDEFCVLLKNGGN
EGRCKQEFLQRLQEKRGEIAFLPTVSYGSSPFSGEDIVKVKDRADQDMYQYKKERKNWKR
LS
>A0A1U7CUS8|diguanylate cyclase|EC 2.7.7.65|Paludisphaera borealis|TrEMBL
MVADRGWRRDATSPADRERGERDSSIEETSAEVSRTQHRWSRWLTAWAEKWFPSALRGPG
DPSGEEVLHDLAKTLAEAADTRTVGKALTAAARRVTGSNAVELIPDSGRRPASCSEMAIE
LRRGGGTWGWLVVNETSSRSSIVRRRLETLGVMASCAFDRLDAGAREVERTAPKPVEVRN
SGRWEGALDKAAEETDLGYYPSAPTVHDATFLNAVFPFALSQARRHGESLAVLCVAIDRL
SGIRDLLGGDQVDRTVQHTGRKIATLIRASDIVARLDDDRLMVLLPRAELDDGLTVARKL
CQGVAENASLLSDAPVLTLSIGVASYPSCATSLYELLDASDAALSDAQSRGRNRASSAPT
LVFDRATRREACAV
>A0A7Y9NE06|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp. JAI102|TrEMBL
MHNVPNLDDASQPLALAWSQTLAQTPAAAAALLASLSAESPPELAHHFYDVLLEDPRAGR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAHAEESATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATDVQAEVIAENLRKHIAQSPVQLATGATLSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDRVVLASDDLPDAPGRQALQRG
>A0A376EMV9|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MPDKILISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTEAVVAGFKKHRYQREWTLPTGRDLAPEIQ
GVSDAFIARSTLLERDEALLDNELNATLALGHMLSIADARSERPEVRTFYVSRAGFYLTN
LPFFGHGSIPELYYQQVSSRWFLDQSLRRNPGRGVRWLHGRDLSMPSGQRVTASIPLDDN
DRWFGVLAMDFPISAMRDFLKNALNDDDGGGEILLFDRQLSPIATTASGSDTALHFTAQD
KAILARQMELGNEGDARIDTRFIAWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARQAAKTCDAQ
HEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAEDIAGRVGGEEFCIILP
GTPAEGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNLVCDEG
>A0A2U3LQB4|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MVNLKYKGVSRYWGLSVVILIVITQQIHNQWQRTIIASLLSIILLLLVEKVSIDHCKLVG
VANSDELTGLGNFRAFQDRIRLEVGRSNQNDTPLAMLLIDLDYFKKYNDTFGHRNGNDLL
QTFGQIMLANVRTTDGVFRFGGDEFAIILPHAALEDARQIALRIRENFSLVGIRGPVTLS
IGLSQYFSGAETAEQFFDRVDSLLYNVKMQGGNGFQLPPVGTFTPSFKQKIALRT
>A0A399EE80|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MLGPELLLCVIALGFGLLLLREARHQPVWQGAAWGLLLWALEELAWWIQRSQGFSAVITP
ADVLFYAGAASWMTTLIRLEVRATPRWGLLLVPALLLCTVALLARPSALLSAVVSSLDLL
LMIFALPVLEPALRGQASVGRLLLGLGIFMRVSAHSAYYWLGEPALGMLDFSMWGGSYAL
MGLGAYLEVRKLERRVGFWPYLLGIASTLGVYLLFIHTASLLYPSMLVEAALLAAYPLLA
VVLAFSGVLYRNRRWAEERLERWTSLLERLGELESGVQTTQNLGAAGLMRRVLDALQPVF
PDLVGIEIRNRESVRVGKAALYVKHFPLYADEAEGRLYFERTPSPSDAHDLEVLGPFVAE
KLRSALSLEEWRNRALTDPLTGLLNRRGLERQIPRLIELCHTSQRPLSVAMLDLDHFKRI
NDTYGHSVGDRVLQTLAGVLRHHLRTEDLAVRWGGEEFALFLYGAGLEEARRVLERIRTE
MRALEVEPISWNVTLSAGLTGGSVPASEGLLEAWILQADWTLLHAKEAGRDRVMVTEPPR
SQDLEPRRTASQ
>A0A8K1IRB5|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MNPSDSTGYGDETPFLSPFCSPEHSDSSSWQTWQHRLDTALLRLRRSLILSELLQQTVDE
VHQLLFDDDKDSYVYICSADPEQQFQILAQSGSFPGDAIVQPGLEIIGLDQFWDERIRPP
EHFFILDNLLSPTTTAAGCEPESPLGKPLGIPLVVSNRLWGVLMIQQGSCDRPWQSFERD
GLELLGSHISQAISHSLQWESRGTAKTDDDPMTGPEAIAQRQRELENTLNAQKIRETVAE
QSAILRSFYNSCPLWMGVEEVVDGDINMISYDQASLSVLFEEISPNPELNKLMDLTDIRP
SSEIFELWLDRYHQAQVEQRPIQFEYQYSTDTQTYWFLATVSYLGIFCYPYPRFSYVVED
ISDRKQNEFELKHVKEQLELVIEAASEGFWGIDYRSDEYYYSSQWKAMLGYHDHELDNSE
ATWHKVICPEELAEVSQFLEDYRTGKINEFLKTIRFIHKDGSIRYIYARAIAVKDSENRV
VRIIGSNLDITNLKQTEIALQESKENYRKIVENSQEGIWVIDDENKTIFANSRLEEMLGY
SLDELRGNSFLEFMEDEDKPAAIEHLRRRKQGIRENHIAKLRRKDGSMIWVMVSVATNTD
AQGHPCGAIGLLTDMTQIVQYQEALELSQMQLKGVLDTSLDGIMAFRSLRDAQGRILDFE
WLFSNPSACELVGRPQENFIGKQLLVEMPGNWEEGLFDDYVKVVESGIPYTKQFYYNNEG
INAWFEIMAVKLGDGFTVTFRDITELKQSQQQLHNLNQQLAARLQDLEQRNQDMKLLNEI
SDFLQSCLTVEEACLAIGSFIRPLFPDCSGAIYMLNNSRNQVKAVATWGNELESLKQFYP
QDCWALRRGTVHSIGPHNHGLKCNHIDTDCTEISAVCIPMIAQGEPLGLLYINGNQGETI
SSTSQELVRTVAEQVSMAIANLKLRETLQQQSIRDPLTGLFNRRYLDEFFDQEIQRAQRN
HHAIGVMMLDIDHFKQFNDTYGHDAGDFVLQQVGQLLSRNVRGSDIACRYGGEEMTLLLP
ESSFEATTRRAEQICQSIRDLRLTYQGQPLLPVTASLGVASFPEQGLTRGALLRAADKAL
YRAKAGGRNQVVVG
>A0A8I2BSF5|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. PvR133|TrEMBL
MMYYSIPVGFNTIADLRHLAIVATATYIGAPATLMATLFICVGRLLLFGINTQAIVGAIF
MMLVGLGCALLSHLSWSRLPKLMIMNVFAMGIIFCSLMINLKNLDDVLHVYPLQLFISMI
GGCLLYLIAESINTSNELLLRLEHTSYTDHLTNLSNRRQLEFSLEEKLPQARQRHEHLSV
LVLDIDHFKEVNDTYGHAAGDAVLRQLGQILMEKCRPNDVVTRSGGEEFTVLLPNCAFRQ
ALRIANQILSGVNQHEFILADGLVLKVTVSIGVTTFPGTGEDMSGAALLEQADKALYEAK
NAGRNRVCSYETYFEA
>A0A330M960|diguanylate cyclase|EC 2.7.7.65|Shewanella benthica|TrEMBL
MSREIIKMAARNLKKAVPLMLKHQIPTTPTNYALWYTYVSEQSPELNKRLDTVIEQHHTC
PPVNAEMLYREYVSDPIEVDVLDMRQNLEAMVTELSHSLKDTNLDATQFQCRIDSNFDRL
NRIEEEGISLEKVLGIVRSLVKESDDIRSSTQYFTGQLNKAQQEIDALKQQLVKSEQIIL
YDALTGIFNRRAFDNDLRGSLSQSPDGLCLILVDIDHFKTFNDNYGHQLGDQVLKAVAKR
LLEACRNGAKIYRYGGEEFAVIIPKSQLSSSRHLAESMRRGLEKISLKDRRKDVRINKIT
ASFGVAQWHKNLEGAELIEKADKLLYEAKRLGRNRVMPIPS
>A0A3S4FM13|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MYAPSVIDTRRSGLSFARRTYLPRIAGLGIGFLCVFSVLYSQQPALWTWGLLIFHGFIWP
HIAYQWACRSVMPFKTETRNLLIDSFFGGLWAAMMAFNALPSVVILSMMGMNNIAAAGKT
LFFKGLAAQLAGALIVSALLGFPFQPQSTPLQIYLCLPMIYLYPALLGLVTYRTAKRLAQ
KKQELLRISMRDGLTGLYNRRHWEHLLHHQFDNCRRYQHTATLILIDIDRFKTINDTFGH
ALGDEALAVLAEELLIGLRAVDIVGRYGGDEFGAVLPNTNAEQASIALQRIQERLNGIIF
REAPQLRLNISAGIADYHGKMGGYLDWLKAADNALYRAKNNGRNRLELAVPGN
>A0A518EU15|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Poly30|TrEMBL
MTDSSADKSLFSLAQIQHLMRVEFNRAQRYGYPISCLMVAVDRLGHLRDLYGYEAKEEIV
DSVINLLKGATRSSDFLGRMADDRLLAVIPHTGGQGLGAMCNRLITNTRKLDFQSDGRTI
PITLAIGGSYDGSDDGGVTDAQRTMFFDALLQAAEEALEDAVAAGGDRALFVTPDELGAA
GLDPAGG
>A0A399F8V2|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MPSTPPRRPLRLNRPPSGGIGLEWLQSLLASRTSEALHARVLAGLLHGLKGVEQALLWVK
DGHRRFQLVAAEGLPAGLVRGLEGVSEAALRGRYGSQGWPESSLQEEEPHPLRVLLGERL
PPGLSQVNRSGAVLTLPITAEDEVWVVVQLWALEARALGPEARGWAAEYLGQAGPVLREF
HLRERAERQALWLAAINALLRAPREQALEVTLQDALEEITRLSGAEGARLVLLEEGVRSL
AQAGWGAGVPVEAAIGPQLVKLAQRGEQVSIPHYELYPGHQAELVKAGLRSLFLLPIQRE
TQEGAALLLFSTRTPWLPDAQTQALLLDMAAAIGVVRREWTLQRELAWAAYTDPLTGLGN
RRAFERDLAHLSAKNYGRTVVLVLLDLDGFKGINDTYGHVHADHVLIRLGGALRAKARAG
DRAYRLGGDEFALIIEGPQSLNPARTAERYRALFEEVRVSDSEYLRASLGYAVLQDVTEL
NQLWREADDAMYRDKAMRRTQTPLFALPQGRASVLQVLSTPLARVARRLGYAAGLLPEEL
EALMAACFVLEQKQQEIEPLELSEGEQRAAARILSFLGARWDGHSMPGVKGEHIPKTARI
LALASELVKLLRPARGHPLPLEEALRQVEVSAGSRFDPGLVELLLRLKNELGLEDSAA
>A0A3S4E8U8|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MAWEISGKSVSLPFISLLFGALWATHIALKYPALGHYDFSFLVISLLSVLFIGSIAFAAN
IVAFTLYSLPSVAVCLWLNGHEQGLRIVYLLALPMVGIAIQHVIQKRYDNFAQQLMFTLL
AERETLNGLSMLDPLTGLYNRRGLQSRLDTLQALDSHKHYVLLLDIDYFKAYNDHYGHMM
GDQALIRVSAAIRDAVRSRDIVCRFGGEEFLVLLTAAEPQQACATAEHIRQKVYDLKIPH
MFNENVATNVTVSIGIAPLADRSIGDAIEKADKALYEAKHLGRNHILVSDDLRAV
>A0A5E4T1K6|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MPPGASSVAGLLPADASAEGEREPPLATMHAATPDPARGRRPSLQGMLRRTHLRLAVSAV
VLAAVSLSLVAWIALRAYAENNLLLIGRSLAYTTEAAVVFGDRVAAQEAIALIANDEDLV
QVRVFDANNAQFAQWRRPDGGALAQVERAIANVAMPGPVTMPIRHDGKVVGSIDVQGQGH
QFFLFLLSGVGGVLACLLVTFAVANVLAKRMHRDIVKPLRALAEVAHAVRRERAFHQRVA
ATPLAELKELGDDFNALLDEFEGWQNHLRAQNATLAHQANHDRLTGLPNRAYFESRLTQA
LADAREMGTHVALLYLDSDRFKEINDQRGHGVGDAVLVTLAERLRQPLREGDLVARLGGD
EFAVMLVGVRQTSNAVRLAQSLLVAMEKPIVLPDGSEIVTSMSIGVALYPTHAEDAAALL
RTADAAMYQAKRAGVGTWFVAGSPKG
>A0A8G0SXL3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MVFPARSQLLPYVVLFGLTLALTLGGVLARPIESLSLFWPVNAVLAGVLLRYPRQATPLG
FALVWLAMVAADLACGSNWQPALWFNLCNLSVIVTVWLLLVRLPRQHRRMRSPQGVLCVF
AACAAGAMVAASMACLMSSPWFQESMRATWLAWFSEQFSTCILIVPALLTAPSRGVLPHG
GGKPVRLAPLLVLVGSLALSIVFGGPGAIAFPIAALLWCAWTYSPFLVSLLALMAGSSLI
VAVAQNLMHFSVPQSVSGVTTLMSARLGIAMLVLGPLVVACVSNANRSLLARLEQQATID
HLTGALTRSAFTRLANALLDSRQQLDQAMPLTLMMLDIDHFKSINDRHGHGVGDQVLRTF
AHALQEQLRDGELFARLGGEEFVVVLPGLAPEHAQFTAERLRRAVQDLHLNHADPRLQMT
VSIGLAGCAEGGPSPALDALLVCADKALYRAKARGRNCVELAEQALRQTV
>A0A0S4LAL3|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrosa|TrEMBL
MIKILLVEDNAVDARLTQDILAEWQLEEFDITHVTRLSEAFRYLARARFDAVLLDLSLPD
GYGLSTVRQIHAANPTIAIIVLSGLSDQALALQAVQNGAQDYLVKGEGPSELLARSIHYG
IERKRAEERLTYLAQYDQLTGLVNRSLFRDRLVQAMARSKRLQQPLGLMLLDLDRFKPVN
DTLGHRVGDQLLKVVAERLYECVREVDTVARMGGDEFTIILEGLMCEEDISSVAQRITTS
LSEPFILGEHHAVISVSIGITIYPTDDHDIDELLTHADAAMYRAKQQGGNSFQFHIPNDS
PSPARQN
>A0A173Y429|diguanylate cyclase|EC 2.7.7.65|Mitsuokella jalaludinii|TrEMBL
MCKLSEEIYRDGLHDRARADLKHLMESTGWSLVKAMQVLRIPPEEQDRCREELERFEPVK
DSFRGNPGDLSEENRILRELMDVVPIGCYILRPDRTVLYWNPAAEHILGFSAAEMQGKRC
VDMPLGCSFTNSDCIEGAYCPAMIACATGRSKSLEMFMRHKNGKDILIRNTLAPLKGADG
KVEKLISFFVPLTDVDYDQGLIRAIYETATRDPLTCLPGRKFMEVCLDESMEIYRRTGQP
FAVLFTDVNNFHDINNTYGHSVGDDILRRLGIALRKYGRKADKFCRWGGDEFVGLLHLKT
LDDIRGAARRFLKIANNCELIEDGQTVVCRASIGITAVRKEDTIESLVSRADRYMYLAKK
RTGSQIVTDFDV
>A0A846UZ88|diguanylate cyclase|EC 2.7.7.65|Dyella sp. SG609|TrEMBL
MSYASIDFVSVLADSVTGAQSLEELVRPLLELLQAVTGLESTYLTRIDTTAGVQHVVYAR
NTLRLQIPEGLEVPWEGTLCKRALEEGRLYTDDVANCWADSEAAMALGIATYTSTPVRIE
DGTLYGTLCAASGERKPLADGAEKILYMFSRLIGQQIERERLVHALRQANDSLAVSALTD
ATTHLPNRRALMDEMRRRLAALGREGGALAVAFVDLDKFKAINDCYGHEVGDQFLAAIGG
RLQSALRAGDFVARLGGDEFVVLSHTPHDSDAEVAAMAMRARLQLATSGHFGLAGAAIDY
AGPSIGMIVATRDAHDAEALIAQADAAMYADKRQRKRMAAGIA
>A0A5E5BWK9|diguanylate cyclase|EC 2.7.7.65|Pandoraea bronchicola|TrEMBL
MSAPNTDKNDLESEYEALLSFMYLSPVGIVRSDKSGFVDMMNPLAAQLLMPLVRGGNIEN
IFDSLASVAPELRNLVASFEAARGPVCENHRVFVTPAKDDAVVLSCSIIKVSTDVLMMVL
TDISRQVAAERRARRTESWLAGIYTGVNDFAFFTLDAQGCVDSWNPSVERLTGFREAEVI
GHMLSRFYANDEIVLHRSPEHIALTRDDGWHVEEFWCETKTGRRYWGQVLVAVLREEDCE
ISGYSVVLRDITERKVHSDNLARLLTTDHLTGVTNRAHFFEIAESEVARAGRHGRALSLV
MLDADHFKRINDTAGHQAGDDVLKRIAGEAKALLRGSDIVARLGGEEFVLLLPSTTAGEA
MVVAERLRVAVEQALIETAVGQLKATISLGVASLGDESQTLQDLLAAGDHALYDAKQAGR
NCVRGAIAEPEGAALSVREEGNPVPT
>A0A3S5D3N6|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MQTPHKSGLQTWAQVAEWTLLGTFVCAIVSIAVNLTLFQGLDNDARLRALVSAVLLPVIF
AFPLFLYLGLKVRDLESVNRRLSFIARTDSLTSCLNRGAFTARIEALLAEAPENFSGALL
MIDADNFKAINDAYGHAMGDEALTIIARSIRAALRTGDLVGRMGGEEFAVFLPKVDERQA
ARIAERIRHCVNTADFNPEGRAHPLSVSVGGAAFEDRTSFSALFRIADRQLYGAKKAGRN
FAAIVHVGDAPDIALRQHA
>A0A1A8THP6|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MSISNNILHHIENFTSQRDKELLAFSLLKSIRDILNPIRTSILTLNGQDEPTMEISLSNS
ESCEYRYQDIRVPESTRASLDYINTWHLDELMKAHDDQYTSFHVLQQSRQQNQYLIITLD
NKPSRSESYIIKGMLSIYSNFSSLLAEAQTDELTGLMNRKTFEESIVKLYQGTAFTDEND
NRANWIAIIDIDNFKLINDSAGHLYGDEVLIHISRVLQQTFRQDDMLFRFGGEEFVVMMR
DLTREECKQMLDELLSNVQSIVMNNLDPITLSAGVCEFQKDTFHVTLMDQADQALYYSKQ
NGRNRVTFYEEIVAAGLAKSNEVTHGDIDLF
>A0A554X3M1|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MSAAPSLSRWTPQRATWRQAAFDDYALVVLALGGLVAVLWLAPFAVYRAITGNWLAAVSD
AVLALTIGGAAVYAWRTRDTRWPGWIMAVAIVGGIWAIGVAAQFAALFWAYPGVLMNFFL
VPAPAAALLGAAAVAGAALLSWQELGGTEGLPFFVITNVLTGVFGYLVSQQAQRRIVRWQ
TLSLLDPLTGVGNRRLMEVELAQAFTAAGTGGTLAVLDLDHFKAINDQHGHEVGDAVLRD
VVAVAQACLRKTDRLYRLGGEEFVIWLPHGDQAAAAVVLERVRCAVRAQVRVGERAVTLS
AGAATHAPPEAWEACLARADAALYRAKREGRDRLVWPLIDEGIPART
>A0A6H2GNW4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0Q0H6P5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MLRVLCFVLFSANLTANEVKNEIDKVLYGYTTFSESRAILEKLEQGMPYKNVLDDARVMA
FKCWFSDVTTSNGLLHYNDFLNNAKSIIHNSGSEILKQNLTVCEAFQEYNQGNYQLATIL
LTPITQNSANTQNPEELNGIANASTVLNRIYLAQGNYEDAFHAAQKAYQLFEKSGNSYEQ
ALALKEIADIHIALYNFDLAIEQLQRSATELAKFNKQEHYKVIDQIAFAHEKSGNLPKAI
ELYQSIKKDVRSYESDNGYAYVLIKLAELYTELNQLNAAKSYLTAVDKLKIDDSWITTLL
TMTQAQWHLKSNNLNAALTLFNKLQTKQNSWPVSFKERYLSFASLIAEATNDSLLHINAQ
QQLIIIIKQKQTDIANNALISARLNFNFEQQKREITRLEQASALQKELLTVAEDKAFWQR
LTLIIASVCLILFAIYSFKQVRQKKYFEVLALKDELTGIANRRAIINLKRSVMQKNLHNK
QVSSLISIDIDHFKAVNDQYGHDIGDELIISVVNTIVSTVRCSGMVGRVGGEEFLIVLEN
QTLENAKDIAGRIRHSIAEKQHTSLGINSTVSIGVIEITPHETAEQAAKRVDLNLYKAKQ
NGKNSVVV
>A0A5I6QM87|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kiambu|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8B3JXV5|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MDTYLQTVKDEWVQLINETEPHIHQVTAQLASDHATALIAEFYRVVLADPIVAEFLTTEQ
VERQLQEALRRWLVDVLSCQVGQVEEQIRAQQRAADVHARIGISVDLVEMGFRMLKKLLL
PIINATPHPSDVKLSVYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLTWEMTLLYKVMLDSSIGNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDEAFNEVRQADDALHDRSRQVKFLRQVRNTLSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREITHATRAGTPLSALLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADALRIAERIRKRVEKIKISSPTGEAISLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKMQ
>A0A0U1KDX2|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MLIASLDALNILSTPVWVAVPKTQELLFANKEARKIAGDCPLPLMRHGRFSAHAQQQLDA
YLPALAGDDHIVEIWTIQTAENIFPLSCRLSLTQLENYGDVIVFEGLYISERVLAQPPMG
QLSSKPYQQNELGFYEQLFNTNTAPMLLIDPSREGQIVDANQAATRFYGYSRDELCMKHT
WEINTMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCVI
HDITEQKRLEEALEHAALRDPLTDLGNRRQFFPLVEHAHTQSQRYGHNFSLILLDVDHFK
LINDQLGHNKGDEVLILLARTLESIIRESDIVFRWGGEEFAILLPLTNLEGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQLGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A0U1K7I3|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MLCVSSVLYTQNAPLWLWIALALNGLVWPHIAFLLASRSEEPFEQEILNMKIDSALGGVW
VAIMSFNALPSVVILSMMSMNNIASGGKNVFCKGLALQIACSLLTAWIFNLPFEPETSPL
QVYACLPMIIVYPSLLGLVTYRTAKRLAENKEELLRISVRDGLTGLYNRRHWEHQLHNQF
DSCRRYQHGATLILLDIDNFKSINDTFGHAVGDDAITVLAEELLLGLRAIDIVGRYGGDE
FGAILPNTTAEQTREVLTRIQEKLADLVFAQAPSLQLRVSAGIADYRHDMINYQQWLKAA
DSALYLAKDNGRNRIELAS
>A0A2X2GIE4|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MYTPSVIDTRRSGLSFARRTYLPRIVGLGVGFICVFSVLSSQQTAPWLWGVLIFHGFIWP
HLAYQWARRSAMPFKAEIRNLLIDSFFGGLWVATMAFNALPSVVILSMMGMNNIASAGKS
LFFKGLIVQAVSALAISALLGFPFQPQSTPLQIYLCLPMIYLYPTLLGLVTYRTAKRLAE
KKQELLRISMRDGLTGLYNRRHWEHLLHHQFDSCRRYQHSATLILMDIDRFKTINDTFGH
ALGDEALAVLAEELLIGLRAVDIVGRYGGDEFGAVLPNTSAEQASIALLRIQERLNDIIF
REAPQLKLNISAGIADYHGNMNGYLDWLKAADNALYRAKNNGRNRLELAVPGH
>A0A2X2G8Z6|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MNARSYQELLNSKHRLSLFLFLLMNAASSVFTLLVPFQNKPAFTLPLIGIPLFCLAALLF
TLQSPRLYVKKLNLFSCVLGLLWAAHIYLKSQHCAPNNQSFLLISLFSMFFISAIALTDN
FIAFCLHAVPSALVILLLDGMHNTMRIVFTTVLPIIAFSIHHLMLKRSELFTQTLVANLY
NERDRFSNLSMIDPLTGLYNRRGLENKINMLPTPPSDCHFVVLLDIDHFKAYNDSYGHTM
GDQALVQVAIAIRDSVRSRDIVVRYGGEEFLVLLTNVSEDYATQVAERVRQRVQELKIPH
RFNQFETTTVTLSAGISALNKLDVASAIRAADAALYQAKNNGRNNIQLAPSIQPAAV
>A0A1C3II19|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MKKDEFQKSTANLKKAVPLMMKNRVSTTPANYALWYTYVDNAIPQLTKDMDGILEYYGIC
PPAVGEQLYNNYVASKSETNINDLRANLELLVSEVSNSMNDTLTDTSAFSEMIDKSFEDL
ARVDNESLSIDEVMSLVRQLVSESRHIRHSTQFLNSQLNSATSEITKLKSQLVEVQKDAL
FDSTTTLYNRRSFDRDIETLCEAKQPLCLILLDIDHFKNFNDTYGHLFGDMVLKGIARKL
KQMCREGIAAYRFGGEEFAIIVPNKSLRIARQLADTNRRSLEKLSIKDRRSGQQVGSITA
SFGVAELEPGESAQSLIERADKLLYEAKSLGRNRVMPL
>A0A174LJG8|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MFFNLIGFIRKDLDLKEAYFKSAENEIAEKNLVLLQISSLLNALLLVLFYIITPYIIKGW
AITLQHFLFLPAALAFFIISTVYAKTGRRNKRVITGICLAFEVTLFAFVISIDVFPYPDA
PSSFLPLLYIAFPALFILRFRQMFTIMFLVEIVYAVAVIQIKNPLMAENDIFNSVVAFIF
SLAVAHVILKLRADDHDIRSRYKRLSMLDSLTGILNKKSCENAISQYLNTNTPVHCALLF
LDLDDFKKINDTIGHSAGDRLLEETGKLLHKTFHASDIIGRVGGDEFMVLLTNYQDSKES
LKKRCTTLQRTLQQIMQNHGVQATCSIGALLVKGQSISFQTAYTLADKYLYEAKSSGKNN
CIVQNLNKE
>A0A0D7LGA1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTDPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A2S6R8R5|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha10_Bin2|TrEMBL
MNRRGFDRELRRALANARRYDECGVLTLIDLDDFKTINDVYGHLAGDRVLRTIGQLLQLQ
IRENDSVARIGGDEFAILLAKCSGEMGISRAEEIERVLNEHFVNFGGAAIPVRGSVGITK
FDKRDDSESIIARADQAMYQKKHENARERARSGHTLLLAPHAGESD
>I4F0C9|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MRRPPGLVAQARQVLLGCALLALALTAVGQAVSGARGSSLTLVLTATVVLAASWLWRYRT
EAAPLALDAVEMLATAAFAVACPDPAIAFGFAFSASWLRMLFGSSRQAVVYGLGIVLAIG
AAVPLWEHFPGHAGTFVRAGALGALPVLFLTITVARYLAVILFSHEQSQERDAALLRFGN
RLMDVTERSDIIKHAWVAIEQICRSTPGLRAIVVRQSTQDVMVLGSAGDLRHPPTALPSG
LLPTAVAPGAVQPLNDVGPLSQAVGLAGHWVAIGMPRQAGDFVLLGCPGRVPTDGVVAVQ
SLLNQLALALQASDAHEALWTQARTDSLTGLANRAAFSSALASHLDRGTSAATLLLLDLD
DFKAVNDKFGHAVGDELLRHVADRLRAATRPTDVCARLGGDEFAVLLTESNAAFARAIAE
RLIAQVSTPVTLCGRGVHIGVSIGVACSTPGITDQDLVHRADLAMYEAKGKGKNRVHTFD
LSNVPLFSTALDRAHAPDPLLSQLR
>A0A7D6UM04|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLMWMLLPKETTLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKNISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLSMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVYMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPSSVIKTNPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>W2UGZ0|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium MOLA455|TrEMBL
MTAPECPPDEVARLQTLKSLAVLDSPHEERFDRLTRMAKRLFDVPIALLSLIDEHRQWFK
SRVGLPLSETPRDISFCGHAILGEGIFIIPDATADDRFHNNPLVVDEPNIRFYAGCPLRA
LNGSHMGTLCIIDDRPRDLKEDDLVALKELAAMAEQELAALQLAMLDELTEMANRRGFMT
LVSHAMRICVRQKISASLVFFDLDTFTSITDSHGHVEGDRALVTFAKILHKTLRDSDLVA
RIGGDEFAALLLDTPKASTLDVILRLQARLDVYNDKSVHDYTVDFSFGVVDFDPQVHADV
DALLAAGHAMMYECKQTKS
>A0A2T7BVF2|diguanylate cyclase|EC 2.7.7.65|Staphylococcus arlettae|TrEMBL
MFEAIIYNISVTVAGIYLFHRLQYSENRIMIFSKAYVTVLMTIVALLLSAYPIPLFDAYI
IELTFIPLLFIGRYTNLIYTVLAAIIVSLVSIFIFDHSIINGVILLVIAIIVSMIGPFLK
QSDIVSIQILNTISLIIYAMLALISPYVDWMEVLFLIPISFVLTITSSVTFVDIWHFFSL
VNRYENEDSIDYLTGLGNVKEFDRHLNKVSREAEQHQESLGLLLIDIDGFKDVNDQYSHQ
AGDAVLRQMSQLLINYVPTHFNIYRNGGEEFSIVLRDYSLDQCVKLSEAIRNGVEQSSFH
LPNKEVIKLSVSIGVGFLTQDDYKSQRKVFKDADDMLHVAKQEGRNQVMFNPIIKL
>A0A1V4W9H7|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin104|TrEMBL
MPKLLTATKISPLDIFLSKSEELKSKGFEVIIPAFNNYDELFTVAAEVVGREDISVSVPV
AVLSSAPGKGKAFREEIIYPIRSLGYRIVLLPGDKAEDSTKELVRAAAGMGIFDFVFDPY
KGEDILFRILNPATLADMGSLLEEHKRTEHEEDIKNIKKNKNRPAIAHWLREVIGWLLKQ
KESQMSSDVCSSKEEEKEDGTLKNSEIDTLTGCYTRAYFEKFRPPEKYSVVFIDLDQFKP
VNDILGHEMGDRVLAAFGQTILENIKGKDVVVRYGGDEFVILLPNTSRVDAENVVANIKV
AWEKAAPDTGNLKVGFSSGVSEEKETLADALKTADRAMYQIKNSTRQVLLPALQPVTAEA
VVAPGEPNLETPLQVTGKVLSTLIKIFTTVILFSIFIWFSNSFFKVIGVKIPLLEAIEKV
LLNLWKDLLIGFL
>A0A8B6LWL4|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SRS16|TrEMBL
MFEDRLQALSELADGVAASLDEAALRDKPRLQQRLAQLTLVAPHAFRTLSVTDLNGYPLA
WVPATTGPQADASVADRSYFSGVLATQSRVIVGPVLSRSLRTHVTIFSSPIYGAEGKVVG
VVVGSIENIALAATAGLGDFAGGPASLVTVASEEGTIIAQRNADRMGESVRTLGPMAKLF
TEAEAPSGLVYGMNADGVPSLMYVTTISGPSSPWRLVMEAPVSKIFTDEAELRWHFLVVL
SAGTALLPLLWLTIRAVLQPLRVLHRQVAAVSLGNTVPAMDTSGLHTSDELELAEAVRTI
SRASTKSLSVEEAETTRLRTALHNVDAGVLVVDCESRITTINQVAARLLGWRVSDALNRP
LDQVYQPRLRASGETMPSLHPALLSAKTALRRVNTLEAVSRDGKAVPLSEASVPVFLADG
STAGAVIVIRGPSAAEVPAVAGVHLRDETTGLRRHCELQSVLTKLFNANGPADGHHAVIT
MDMAGCGDQGPNLGQLRNAGKAVRETLRMGDRGFRWTEASLLLVLKNCDLPEAAFLAEDV
LGKLRASDAQTAPQVSVGVLAFGPGPATWTEVVQAATRVTDAARRQPGAVYIAPESNGAG
MLDALGDLFGQAPAA
>V5TZ99|diguanylate cyclase|EC 2.7.7.65|Cronobacter malonaticus|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISAQRNQLDSTATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIDGFKAERDKPEWTLPTGRELAPEIQ
GVSDAFIGQSTLLERNDALLYSELNATLALGHMLSIADARSERPEVRTFYVSRAGFYLTN
LPFFDHGSIPELYYQQVSSRWFIDQSQRRNPGRGVRWLHGRDLSMPSGQRVTASIPVDDN
GRWFGVLAMDFPVSAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGNDAALHFTAQD
KAMLARQMELDNEGDARIDTRFITWAKLDYFDGVLVKVTTVSQSAEGRFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRVQDVAGRVGGEEFCVILP
GTPAEGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A174ST57|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MYNKNKKIKHKTLKICCLLIGTIVTAVFLEAGILYLVNSQNVYKTSKVLLDQTIEIVEKN
KQSEVRTVVADIPVYKGIALYVADKETGRIYGATDVSKIGVKLDDMGLRKQRKKIAKEKI
ASGIIRVDGKKNYYILKKTQKYIVGITYWIAVDNKSNLIAILIMVVYLSIAAVGILFMVL
RLSKVKKKNKEQSVMISSISEMSNIDKMTGCFNRKAYDEDISEIRMDSQFIYVSMDVNGL
KIINDRQGHAAGDELICVAASCMKCRFNKYGKVYRMGGDEFAAILFVKREQFEWIRRQFD
GDIKYWSCNRIKELSISYGYVSSSECQWDSMKEISDVADIRMYEEKAMYYKKNGVDRQGQ
PASYVALYRLYTQILRINLEKDRYKIINWEETKNKKKQDSIGALSEWFHNFEDIRLIHSD
DLVKYLRKTKIEYLKKQFANKKKFVTITYRRKEGDGYKRITLEIIPEDENSQNTYEGFLY
VKE
>A0A0Q0JFU4|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MIENSSLILVQVICLLSFAATIAWTVMVTPMRVAPSASWRFALANFSILIGMLLYTQRTF
EPSYLHWLIADNIILVGFCLLRWGAQRLYHLNSSYQFDIGVLLVTCGFMLMVQPQAENAS
YLMIILSLAASVLFFMLAKDHYTAFKANFTAFATYWLVVPIFLIGLLFFIRSVILIIYPE
KVATYAAFNTEQSIPVLWTYIVLILVVNILIIGNTINRLVVKIMTLANKDPLTALWNRNA
LQKKLTAEHERWLRDKVMYSVVLIDIDHFKQINDTHGHTAGDEVLKLTAKRLSKVTRKID
FLCRFGGEEFVLILPNTTEQQVLCVADKLQQTLAEIDFKWQGTPIQIQASIGCVTITESL
AVDSLLQLADKAMYEAKASGRNCIKSAN
>A0A2K9JUF6|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MNTWLIYLLEDNDEDAYLVKRTLASTDGRQKFNVKHFKNLEQLETALNTVKPEAILIDLN
IDESQGLTTLIKVKQLPVSAPIIVLTGVSETLFGEKAIQLGAQDYIPKHEVSGPLLARTI
TFSKERYEMQRNLENLVVMDRLTMLHNRGAFDSELERAISESERYGHGFGVLFIDLDNFK
PVNDQLGHQAGDQLLKILSAKLKMYKRASDFVARYGGDEFVVIAPHLTEKNQLRKLAQHK
YDLLSDNYCLQDESANIHEVKLDLSIGAVIYPTDATSAEELVAKADKAMYHAKTNKLPYA
LYSDAGLTTKQE
>A0A6L5BP91|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MTHNAIQRLLLKRFALAAGTYALALLLLWLAFFTGHYDVPLAGVAVGSALVVISQAALFA
VFYSGCNLRFADPSLTEVQVLLGLAWQTWLIAHLDEARGAFLVFYILILLFGLFHLSRRA
FVRCALLVFFSFSAITLWEGYHFQLSDPALSLLQVCVLFIVLVWLVLYARYVQASRQLMR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLASRELNAMEPGVVHGLALI
DLDHFKRINDVHGHAAGDQVLQAFAGVATACLREGDVLARYGGEEFVVLLPYCDAERLTS
CCERLRIAFTDVELFGLDVSNLSLSAGMTLLELGDDLDDALQRADQALYRAKRDGRNRCA
AAWENVDA
>A0A752GFG1|diguanylate cyclase|EC 2.7.7.65|Salmonella moscow|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2H9YWA5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter pseudolwoffii|TrEMBL
MNNECMAMLAEQWRQICQNYSADDLLHAFHFVQEHSVILVEEFYKNMLLEKESAQFLTEQ
MVQQRLRNTLIQWLSESFSVPINKSYVQAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
VFELLQASSQNSMLTACSYIVQIMGFATEIMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSSPDNLKHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDAINQTIMDCTDKNNVLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTVISREITFSRKNHTPLSLLAMDADFFKSINDKFGHAAGDLALKFIAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDKQRALSIAESIRKYVENGMIKTAQGQQFKITISIGCTL
YDGHPDYQRFLDAADAALYMAKNTGRNRVYMAQSPSNPVGQQ
>A0A742QVY1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARATDDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6L5BZ54|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MSLFKPDTRPTLRSVIGRGHLIVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKAAATEALALIASTEEVADAQVHDTQGALLARWQRPETGLLSDLEMQIAK
AFLEEPINMPIVHQGREIGSIQLTGHGGSLMRFLLSGLMGIVVCTAISAWVALYLARRQL
RAITRPLRSLAFVAHAARSERAFDQRVPPAAIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAHKLNERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVATRVRAQLREEDLVARLGGDEFAVLLTPLHKNEDAERIADKIIASMEVPITL
PGNTTVLTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRLSRGAQHTAGSEHPVVHVQT
RS
>A0A157QHK8|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MNGKPALDQRIEALLADPAYAGHPLREALDELWRQTQEQMARIERVTQISDAYQSMALKR
EQGLYERFDRQLRRLSRIARISDHYQSMMRDLNQTLEETARRDPLTGLFNRRALMEMIRR
QVQRSARTGQGFVVAMLDVDHFKSVNDRYGHDTGDRVLVELANVLLQSIRATDQCGRWGG
EEFLLLLPDTSLTAAQPALDRVVEGVRALSVGVGDETLRLTVSVGMADHRLGETFSETLS
RADQALYLAKHDGRDRVALSAGQS
>A0A6Y0SW29|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQIAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3W0NCW6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5T7KV82|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A174E8C9|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MKKLSRHELMQYGTAIISFLIVMTFTLLIFFWFVQQSVDKSVQNVLQKNTLQQKDHLELV
LEKEYEFLESPAAYFGTTSDLFSNDNLQLLAELASSSSYHRLMLFSTDGIGHSSDGKKTD
ASSRDYFQKTLEGRRVISSPLSSSVDNETLVVLTVPVYDKDQNIIGVFGGSIDVTELTTM
LFEDLYSGSGYSFITDPDGNIISIESTHNEIRKNFFTSSSDWVFQTSEDGATLQEDFKQG
HANCRKIISDLSYARYISYQPLKYNGWMLCYIIPAVDARQPFAFINNFEIILFAFFICIV
LLLIFALWKINQKNQTSLLRQAHTDALTGLLNKVYAEHTISEWLREKDFEDLQALMMIDM
DYFKQINDTYGHATGDQVLKIFAGFLKEQFRATDIIGRVGGDEFMILMKNVRLDYSIHLH
LQKLYTNLQNIDIPELNDQKLSCSIGCAVAPTDAESFSQLYRLADHALYTAKHNGRGRFV
IYHDIKNHQETVLS
>A0A5U4DK24|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLTSCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W8RH07|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. Cpub6|TrEMBL
MDLELDHRRAGMRLPSASKTPAKTVWDRVSSRPRHTVILCFGVVFVVTLILAVHQYFLVR
ARELDNRSHRLEIQARVLDVAVRNNRQHLQFLRESAERLLADRTAQLDRTPDASLQAVLR
AQDERVWNLQVRDIDAPIRGIGTQQLAVTPGLHRDEPTFVEDLRLAQMMSRLFAVQFQMG
TGLERAVYVSPTGIVVAHPTIDDDEVVRLLQMYGSSRLLQLANQNPLDYDVTFDPVRGRK
NPAGPRLLFGTAVMSNDVVRGLIFFVVPQRIVQDYLWNNTTADETHALIDPSGMPIATSG
STFSVNDENWLKTLPAQWNTLSASTLFRTPSGTLSAGQDFLLFRKLDTADLVLTDYVSAA
TVFFSVVRLSSALFAGVWILMALLLWATLFVVDQLLSTQMALNGRLRELSLADPLTGLAN
RRRLNEEFDALSRRNDERRIALLMIDIDHFKVINDNWGHTAGDETLKHLANVVRIAVRPG
DLMARLGGEEFCVLLPDTTADDAARIAERVREAVARNACVLQETQLTRTAPGREIWFTIS
IGVAESVSDNCFDLEGLIAVADQRLYAAKAGGRNRVVASESMQS
>A0A0L6Z690|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MMQQVLNIVDRNFMKVDILNGVRRVQYAFYEKNVECFLAYDNDTLAGVVTKKELVGAHPN
RIVADVMSNRFIFVNCYAHIWNVKEIFDLNKYIDIVLVKNEDDIEGYISRTALNIELGKH
IDLLTGLYKSEYMFYNAYNLLKNGTQLAILFIDLDNFGYIDKKYGHINGDAILKNVANIL
KDTLEPNSYLCRYAGDEFAIVTSYCIENSRLLAEKIISSINTYPFSNGIPVSASIGITGC
SINNSKIKNISELINKLVNIASLASTKAKQNINNSIIIEDVDINAIA
>A0A2S5D5Y5|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MQIGEVTENVPSIDEFVKNKDVDLLFTSNPSLRSVVVVRDGSPIGHITRTHFYQKIGTRY
GYNLFMGRQNQLIIKENPLIVDYDTPIIEVSTEAMGRRAEDLYDDIIVIKKGVYFGVVSI
RELLLKLVETQVAIASFLNPLTSLPGNKLIEEKLQAALHLETYSLIYFDLDHFKTYNDTY
GFNKGDKILLYLTDVLKRNIAGGEDFLGHIGGDDFVAILPHYEVAIICQTIIEEFDAQII
DFYELEDLVKLQVSNRAGKLERFSCTSLSIAVITNEYQQFTSVDQLSDAVARLKKECKKI
YGSCYLINDKATYLIH
>A0A378YM07|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MTTRLPPTHPPPPGAGSAVAGLLSPQTTAPDQYSTGTGAQATSASTTHSPPSASQPAAPP
RHPAGPPATTGTMGRRRRRPSLQGLLRRTHLRLAVSAVVLAAVSLSLVAWLALRSYAENN
LQLIGRSLAYTAEAAVVFGDRVAAQEAIALIANDEDVVQVRVLDAQDNQFALWRRADGGT
LARVERVVADIALPGPVTSPIRHDGKDVGRIEVQGQGHQFFLFLISGIGGVLACLLVTFA
VANLLAKRMHHDIVKPLRALAEVAHAVRRERAFHQRVAATPLAELKELGDDFNALLDEFE
GWQSHLRAQNATLAHQANHDPLTGLPNRAYFESRLSQALVDASELGTHVALLYLDSDRFK
EINDQLGHDAGDAVLVAIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRLAQSL
LAAMEKPIALPGGGEVVTSMSIGVALYPTHASDASALLRAADAAMYQAKRAGVGTWHVAE
SPKE
>A0A1V6GVQ0|diguanylate cyclase|EC 2.7.7.65|Thermotogae bacterium ADurb.Bin062|TrEMBL
MGETASFFSRLSQWIAIIAVLSIVVFSGWFTNSTLRAVERTLPNTLLEQLQELTVIVEQA
AEAVTLAERARSQASEPTVRALKAQIEETYQAIVRMRESFVFDNLIQASSFHATLAPALV
DARVWIEEGVGGIPPDSPMVLQIIVSRLSNALVQAQQLNQESFSVARNILEEQKDKLDTF
LFSANALFILTLCLSIGVGYLIFLQQRTQKREQVAWAERALIEKQLEYEAKHDHLTGLLN
RRAIIDILNTLLNPAKAVPMSITIGMIDLDRFKEINDRYGHQIGDDVLKHFVDVVQPCLR
ETDLFARLGGDEFLLVVPNQKEGAETTVFQRVCDALRAKPYPSALGDIPMRASIGIATSH
GRIALDELLTRADKALYHAKNTGRNRIIRFSECPVLKEENIFRHNSMEGRRIL
>A0A1N7SPF0|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia ribeironis|TrEMBL
MSATIEMRDSPAAVTLITKLYARFVLAGFALMPACLIAYLFFFQDLTLRFENHLFHEIAI
AAATLEGLFVAYVTWQCYRSSGEPLLRWLTLGFLGFVLIYALHGAFTSMAHHNIWLFLLY
GPASRLVMSALLLVGLLSYSQPADSIERRTDWRGWLKWIALFVLVDLAVAGIAYSPVAGT
LAVRLSMEGGAMILSALNVLVLLLRRIRTPLMVMFGISVTSFALSSLAFILGRPWNHMWW
LAHAIFAGGFFLLSYGVVQAFHTTRSFATIYSQEELMARLAEAMNRAESALQELQRTNDR
LEHLAATDPLTGAANRRQFIERVEAEIERARRGGAPFSLLALDLDHFKAINDAYGHQAGD
TVLREFVQKCIEAIRPYDGVARVGGEEFMVLLPRAGLDAALATGERIRSMIASSVFGAGS
GRCGEVTVSVGASQFGRDGDTIDTILRAADERLYRAKHLGRNRVVVA
>H1WLM5|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MSVRQFASSTLLVDIDRVLANTGVNPQAIKLEITESALMDNPEMAIALTSKLRYVLRTRY
ANAKNWDQFG
>A0A5M9IRA9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MKTPTQTHAIDFDTAKLQRLGFGQPTSLPRRPTTIVQLRQQLGQQLQISLEPERILGLFF
REIQRLVPLDALLYRHQASDLRLEFGHRGHHSVSYALSHEGEHLGELVFRRNQRLVEEEL
SQLESLLATLLYPMRNALLYRAATRSALRDPLTQTGNRVAMDQTLQREIDMARRHLNPLS
LLMLDIDHFKQINDTHGHAAGDNVLRAVAAAIKAQLRNVDMVFRFGGEEFLILLSNTGRD
AAAMVGERLRQATQAQDYWADDLRIELTVSLGCSTLLAGESADSLLRRADNALYVAKREG
RNRLAMAG
>A0A1S8L8D2|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MNIINNRYRIINTIDKKQIFSSFEVTDILRNDSNLKLNIIELRNIPNNTKNHIKNEFINL
VNLNENYIYKLYSLNVISTIDNKTEDDKRWYYTCEICKESNRLVEIMDNLEENDIIDIFV
QICIAIQYLNNSGYAYRNINSKNIYVKRQNGKVNIKLNDLISSELEKIKENYAGKREWFQ
FDFKLDYGEKYSEIVSNEIRDLGILLFELCKSKFSSNTKINNSLELQHNVNKAVTIKNPH
KEFEMKIIPIINKMICNTSERYTNIKAIVEDINIVFSRRYNIYDVKAFEKLNYNVKIVGR
DGPINKVLNLCSIFKNVVNKSNLFIVHGKSGIGKTRFLKEIRYFFKFNMDNVYCSFGNRD
NITRNIFDEILKQILTSYDTRIIKSYEREIGKKIITKLKDSKNITTEEEKIDLFDKCINF
MNVMASKKRLVIIVDNVDKVDELSTDFIKYFYEKVRNTKNIVFMFSYLDEIIYTNNDVGQ
FISSFKVNFTDIILNELNFVSTNELIKEVLGTSILPRDFSKKIFEKTKGNPGFIIEVLKG
LYVRKYIYVSKDNGLWVTSYDKINEIPIHSSLVKNIQNQINDMCGFELEIVNAMCIFNIG
LKLETIKMFFKEYDGENIEEIIRKLLKRGIIEAIEEDSDTYYAIANKTIKAALTDRMDEE
YKSSINERAAEVLEKSNPSKYKEEILFHFEKSLNVKKIIEYYLNKYQYPIYIKNKREVVS
KIKKLVKTIRNNTTLSGIKLLIILGDLLFLDEKDREAQEYYKLSEKLLHERKEYEIQFQV
LKRLVRMLQNNSQLKESRIYIYRQEELLRNWYNLELELLIYTEEAFNFYLTKEFERAISI
CNNVIDKCTHDMEDVKFYAYYVLSNSYIEKGDMKQAEKYSKMCSDKRYLKDNLPYVLDSL
NNIAYIYGNYYEEYLQCKNYLFRVFQIATHFNYSHFKLLSLSQIATLDFKQGSYKEAYNG
FENVLGLSEKINDKYIELYCYCRLCKVCLVMYDIEEAYEYFLKASTRIDDLKNYLDLMGV
YYSAAVEIYLKMGMPEKAKEYMKEFKDKCGAQNIKKIDEVVGYYIDYLIDSNETAITTFR
KALSGMDFTNKNVNSIVIIVQIAIIVYWKKDLEMFNDIYIMLSRCNIKNKLVRDCIGIIR
TLNLSNEEMLKYAINTLRKCENDIKISKFLYVNICNYYLKSGSYIRAINYCFEYIDFMWN
YYLKVPDKYKENFVRCYKIKNDLREYIDIINNYMGQKIVDEKSVEGILSKEGIEKFYENT
DLKKLFYTKQLKKDLKKYYFSFIPRKVNSRINVMRNQVESSVINIQNILKYLKYSLIAKK
IYFIVMPTQTEDTVVFTHNQNFVDNNIIKENTIIYNVSSKRNPIFIKRVGLKPNMELEES
IKAVICIPVYTVLSNLNKRNNKEITGILYIESDKILNNFNVNAINKCIEFNGLISLNVDK
YRLKMSSTIDVLTGTMTRRHLEIYMDDLLDENRNFIKEFTVLMYDLDNFKAINDKFGHGT
GDLVLKEVSKIVMNNIEEKSVCARYGGEEFIVILPNHNVLKAYEVADKIRRRIDKAKILG
NKRSVTISIGLVAYPDMAISKEEIFEKVDKALYIAKNTGRNKCVIWNERFNYKARATNKI
TGIVTGNPVKDSRNVLVTVEFIEMLKSSISTEEKIFNALGRLVEFFEATYCTIILLKDKK
VSNVYTRKIFKSDFIKKTYINDKIVREVLEKKIGVYMIDWDNISGFDETTGMPDWDSIMV
IPLINKGIINGILYFKVPAKIKEFNFEEFNFASAISNIVAALF
>A0A1S8LCG5|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MNLLSLFSYGNFVLFLLLSIYSIQFSPIRSKLNKYSFWVCLALGEWNLCYVFFYIAPNSS
TALIWHKLALIGMYCFPAFTLYFFIVLTKRDTIFKNKYHYFIFYLVPAILILISLFSKNT
ALVQALVQSSSGLGWTYVNSTNSILYWVTLLYLYCYFYFAFFLLYKWGKNSNYIGEKKQA
RIFILVDATILMLGSITDFFYPLIDNFLPPMANLFTIVFILFFIYIIRRYNMFDIHHIAS
PELIINTIMDPVMVLDENFKIIRSNPAAENILGYSSSYLKNKNLVEFLLGNTDINNKILM
ELLETKEFKNKELNVITSKGEVINSLFSASTAEDRINGFLGIMITFKDITEIKVIEDNLK
FVNSKYRKTADKLYKIANFDPLTRIANRRLFFENIKQKIKQYEQTSKDFGVIFMDLNGFK
PINDKFGHNIGDKALIESVCRLKLCTYDEDVLARMGGDEFVLIVSDTSSINERINKIKTL
FLSPMHIDGCICNLGIAAGTSIYSQSNRDLDELMRIADILMYEDKKKSKVR
>V6F5V2|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MITFTDPVDIAAHCARAAMGMMDRYGVAAHPNNFIVWYAFVADRDPELSKAINGILRSGQ
KFTDTVCNDLYERFFGMSQHEAELRAVGKRIEDAVARVMDYLSTANQGAIQYGSALENFS
GELTTPQPSADLGNLVKSILDETKVMIEVNRQLEERLETSSGEIARLREDLDQLKREATT
DALTGLANRKLFDVSLREAALESEEDRKFLSLLMIDIDFFKQFNDTHGHMLGDQVLKLVA
RTIQDCIKGKDTAARYGGEEFAIILPDTRLKDGVAVAETVRRQVAGRKVLNRRTGQVLGQ
VTLSVGVAEYEFGETLGAFIHRADEALYLAKRQGRNHVASQDDLTSSNTIEFEDI
>A0A1Y6KVB9|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MNNDLYFKYQPRYYNGEISSYEALLRSDINNFNVEKFVYLIENSAAFDLNIIGKVLQDRK
SLHICDDVSISLNISIASLLDDVFIRKCLNIFEHEKNITLELTNHDQTDDFDGIQKSILL
LKEQGVNFALDDYGKGYLNTDIFLYLDVDYIKLDRRLIRNIENNYISYSILKSKYDHIVN
VLDKVVILEGIETFEQFNLVKEFGDMFYQGFYFSMPINIGDIEKTSFTKYKVKSERIQFS
LQLDQAIFDLNRSQEPKNVKQAIDNIKRIDKYNIIGLTSNTFDLYSERHRINKNYREIIK
NKKHSHYMLAASLVCGCDGAVVIRDVDGNVIFNNDHFIRFMGVDLVDMPIDQVCEQVTDY
RTTLHVESELLQSDSCFMMSDEVMKTKNGMELVHVYRQKVSHFGQNFVVCSVYEAIDTIV
IDELTNCYQKNYLSSSYMKQHKILVFIDLDGFKAINDNLGHCIGDEILRDFAQTLKSMLR
DSDVMVRFGGDEFIILLNSHVMTTVQQRIVQLRTDIEAYFSQKDMKLSFSYGVASLQNGV
ETALKQADNRMYQEKSFRKRKLDTVKLA
>A0A6F8ZKL9|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium R50|TrEMBL
MAGSVLLVHGLVLAAVLVATFEFGIFARGQRWLPNWLACLAGMAAPPVGLALLAVWGREP
VPAGVWPVLVVAQSFWLPRPCYAGSALLAAGLAAALTPGARPAVAAMVAAVAVAGAWPGV
RHRALLLAGVVLAAWAAAAAGGWPAAGGRLPVRAALPVEALAGLAVAGYILSHEQRLALL
REAETAAEADALTGARTRRGLERWLAQWAEPPPGVVVAADLDDFKTVNDTYGHVVGDEIL
REFAARLRGALREGDAVVRPGGDEFTCWCPGVSPAAAPELVARLHETAVGTPFATRAGPL
RLGCPWAGQPALWGRWSRKRRMGPFWRPSGRVRGGWWGRWPPRAPGCRRGWRPPQGRSGR
PGWFRRPCWTRLAAWWSPTWPGTGGGNIGSRETTPGCRRRPGPPVPRYRSGSADRWWAAG
GTGPRPPGGPGGQTRQARGPTRRY
>V6F332|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MSVTEYLYGMLAGLTALAALVVAVRLLAFTIRCRAREGRLLVMLAGATTLFALCGANLVN
AADNVLWHPNVPIVPSAWLSSVSGLVICVWFEVFGRYAVERSGFERQLEALANTDSLTGI
LNRRACLERGAALVEAARRFDHPLTVMMIDIDHFKRVNDRHGHEAGDEVLRMFTSVVQGC
LRQVDVFGRLGGEEFAVFMPETNHEGAAIAAERIRASIEKAELSRNGKALSITVSIGAIA
GSESLDEALRKADEALYRAKQTGRNRAVMVSETLGEPA
>A0A5P9B7K5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MKANPILLIVTLMLLGSFVMLGLSSVTDIDSNYDLFFETNTLIIVIYVYAVARKAILPHK
ILHFGALLLIFNLCYDVATELERLDEWADRHELIDTFLEDGLLQIAFLLIAIGITQLTSS
IKAQSHIDELTGLFNRKKFDTITLAEFDVIYLDLDGLKRVNDLKGHNVGDLMIVRFSQVL
RQAAVQDELLFRIGGDEFVVVALKGRSAEFIDQVVNLLHGENIDFSYGVAPATQDTFQQA
LVASDKAMYTMKKAKHSLKCV
>A0A5P9B5M5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MDALNIEATEQLRRKVLIGMCLNLGGAALFLGVANIFIFEHKAMALGVMEIFYFFISAFM
LFYIRNRSHPKWFLAFHSFVLAFLIIFGTHSKLIEEALFVWAIVLPTVFYLAMGKQVGFY
WSLVCLILEVYVIYLGASATDWIPATLLANFILAYLCIWVVSHAYETSRVRAVTDLKALA
LHDALTGARNRLALYSTVDGQKGIDELQYALVLDIDDFKQFNDLYGHDAGDAVLVECVKR
IQNIAGESNTFRVGGEELVVLIRHGEFDIQDVVTQLHRAVSRQVLMFGDVKLSISFSAGL
EKYRTTENFDTVLARADADLYQAKQAGKSCTFYQGSKFAES
>A0A2H5WT74|diguanylate cyclase|EC 2.7.7.65|bacterium HR15|TrEMBL
MQGGEAVNSRALMVVEGQPPFYSKGVDHLLAPRAEREPLMRTIAHLVKPVRVWVNPDHTV
ETALILLRGHGLSGLLVMEGAEVRGVVEAPQLLGARLEQPVRDLLQTEIPVLSPDTPLKV
AAEWFMQHHRTVLPVAQEGHLVGLLTVFDLLPEIGRSYDPMTGLPWSDFLREWSIEQLAA
GREITVIFFDLDNFGMFNKRYGHLVGDEVLRRVAQIMKEEIDPDTEVVCRWGGDEFAIAT
LRRREEAGLLAHHISRQIAAIQLPDVDTPVMVSYGYQGGKRTREREQVHYAATVDNLINL
ASQECLLMKGAQGRAQGAQLALPMQAVTESRPAERRIRIQTVSYEREGRRARARVYLQMD
STPLSGTAEGEANLPRLVAEATLNALRRALPTPIAITLLSITETTIDTGYTIVSAVLLWE
SEGVQQELVGSAFLREDAPRSVAAAVLDALNRPIAHVLR
>A0A6H1FTJ8|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. FDAARGOS_727|TrEMBL
MHNTRLLRPERRKKRNGWFEKIAARFVRQGAPTLIGNVFERFLSRYKRPQRVVNICFIAV
LLFSTVLTWREVSVLESAYVSNQRNSLDNIATALDRQLQHSIDNLLFYRNTMHYAMQSPI
STDISRKLLANFDIERTQPYWQLRLDINRGMPINGISDESVSRSPLLKRDEALLHPELAA
ALEFSYIIQLADGKRDLQRRVFYASRAGFFLSSTPPENDPGIVALYHRLIDQPYFAAQSP
QNNPRRCVQWTHTFNPSSQSGQIITAALPLDFEQRWYGVLAMDFPIEAMHQFLQNSSRDR
YEGTVMLFDKQFNLIATGADKVPAGQLFDDKQQAEIARSMADGEEGELRMDTRFVTWARL
TNFDGVLIKVHTLDEGVRGEFGRISIVLTVLWMLFTLMLYISWRVIRRLVNSMLALQETL
SWRANYDTLTRIYNRGAFFETARALASDCQRRQEPFSVIQMDLDFFKGINDRYGHIAGDK
VLAHAAALLSSALREEDVAGRVGGEEFCVVLPGANLAAAAGVAERIRVRINNKELLLMAG
QSITISASFGVSCAHERHDYDFEHLQSIADGRLYKAKQNGRNQVCAADSSAGPDSSGV
>A0A4P1JQW0|diguanylate cyclase|EC 2.7.7.65|Brevundimonas vancanneytii|TrEMBL
MPNPTSAVAAPSCVPEPSLDPQSLERLRALLNANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRRWLIDLFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDAAAFGLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRASLMEWSQKTLFRILASGGVDGAGALGASPFGLWIRHRADFLFDGSPHLTRLNATME
RIDTELLPRFTPDAIPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHR
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGA
>W1EPH4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae IS53|TrEMBL
MVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVAQEMDGLLQFNIDRMMFFRHG
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGDNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVITHYSQALS
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQ
GREVFLHNNVTLRVSASLGVSASEEWGEYQFEALQSVADGRLYLAKQNGRNQVCFRSAA
>A0A0T9U0M5|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSELEYLSTLYRDTCVTYATLSISYFVLSKSSAFSYRGDVWKRVVFGLVAGLVSLYLNQD
QWIISGSFFYSFEMIPIVLVTFYGGWLSGLTALVINIAFTGWLTLDNALIAIIFISLLLA
KVWTKKNNRVFYTTIVLIAIYRMVVAVLIVPDKLLWTPIVVYQLISALCLAICYHALNFK
ERHIDAYFTMKNRANIDKLTQLNNRASADYRLAAIHSSRQACGLMIMDIDHFKHVNDTYG
HEGGDLLLAAIGRLLTANVRDKDFVGRFGGEEFIIITYSHDPDDIKGVAERIRQQVEKLS
VELPDGRKTSATISIGASLYLPGMSMLKAMKMTDDALYLAKKQGRNQVVYSRLMPFSPLG
DRITRERRRRKSA
>A0A7W6XRF1|diguanylate cyclase|EC 2.7.7.65|Rhizobium esperanzae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGHTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLTRAGEGRADETAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELLARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAATVAERLRAAIESAPFMLKHAGEALNVTASFGI
ASRIAAVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A0T9V486|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSRSILSTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNTLEANRVYATK
LASSTEIFLRSAQRQLHYSSMIAAKHFDDQALLQAETARLKYQTDSFNSVVVTDAHGVVR
ATSPDSLQLLGHTLTSPGSVEALKLRRPIISRPYMSAANNLVINISTPIITPDGRYRGYI
GGTIYLRKQSILNELLGEHYYRDGSYIVVLDNEWRILYHRDANRIGEILESKPLTEMAKN
ATNGSLMVTNTDGESMLAGYAIVEPSDWQIITLRPEVATLKPLEGLMLKGLGHITPLALL
TLMGVWLLSRLIARPLWLLAGSANAMDKPDIASSIKEIPSWYFEATQLKRALLIGISLLQ
KKIGKLRFEAQTDPMTGLYNRRGLATTLEPISQLEQHFSVIALDIDHFKAINDSYGHDVG
DEVIKQVAVQIRESSRDTDILCRSGGEEFLILLPGTTPDVAIQVANRLRHNVEMMVMPNI
RPITISLGVAYWSGDGMPEDALKRADEALYRAKDQGRNRVEIS
>A0A238JB48|diguanylate cyclase|EC 2.7.7.65|Pelagimonas phthalicica|TrEMBL
MTVTDTHLTAPSPCAPRAFVDAFDQFPEPVILTDLARRVIWCNAHFENLLGYDLSTVQGT
STRSLYANRQDFDHIGGKRAIPKRDLDRRCYTAEYRHKDGSKIFAETTSWPVKDAEGQLI
GFAAILRDKTASYRVNEALSDLYRISSSQSLTGSEKIDAILALGRRFFGLPIALVSLIRD
DKFTVLFSNCAHADIPPTTQFCLDETFCHQTLETGAPHAVHQIDENSDAQTRAVGDKTGL
QAYIGLPLTVDGERFGTLGFSGPAARPAFGKADFDVLKLCGAWIAQELSLEMSYQALTRE
AQQDWLTGAGTNRAFRKTLNMAFAKTRLSPSSAQLILFDIDHFKSINDRFGHDRGDVVLR
SIAQAVQEKLGRDLQLYRIGGEEFAVILEQCDTQFAVDLAESLREAIASLALGFDTSASF
GVSPAAKGFKTENDWLKCADLALYAAKHNGRNQVVTNNGVPSLRVSGKCPMTSCPESEEC
NARRSSA
>A0A445ND00|diguanylate cyclase|EC 2.7.7.65|Streptomyces netropsis|TrEMBL
METESEPYVRLATLRQLHQVVADLNTARSLADTLQTVADGIIAGLGYELSAVNLVRPDGD
LVVAAVAGSAGAEALMAGRVGSRVSWERRLAMGDHWGDLRFIPYTEGWVLDDDDVPQWHT
TGPAPRFADEWHPMDRLFAPMYTAGASGGELLGVISVDKPRNGRRPGAWGREALQMYAFQ
AAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLH
RTNDALCRLLGRSASQMRRYSFSDLVHPEDVGTLLRTSAEGGRAELRLGRRDGTYVWVSL
RNSVVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLGSRLCD
RPAGSETHAAAAVGPYGCLDGFAEVESAAYGHGFGADVGPDYAPERGGESAPDEYRGGPE
AGYDHHVHTIAPDEETDDGIKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSNGV
RDGDTVARLGGDEFVVLADGLGLADAEDLAVRLRNAIIPPIRVEGRAVRVGASFGIGWAA
CGMSAEEVLASADQRMYVEKRSRSKAGRRAC
>A0A806X7H6|diguanylate cyclase|EC 2.7.7.65|[Enterobacter] lignolyticus|TrEMBL
MEMYLSNMTDEWTNLVENTAPRIRSLASEISRLHAHNLSIEFYNTVLTDPHAEEFLSNEQ
VERQLKAALARWITDVLSGKTEDVNRLVALQQTVANVHARIGIPVELVEMGFRVLKKLFS
QVIIDSECDPSDKLQVYHYVMNSIDLSMEVMSRAFSFSESSTTKEDENYRIFSLLENAEE
EKERQTAALLTWEREVVYKVMLDVGPERSLPLNQSDFGLWFNHKGRHYFSGFAEVGLISR
LIQELDGFFSHTRDTAKAFSDKKQRGNFLLKVRNTVSQIMTLLRELFEEVARQEVGIDVL
TKLLNRRFLPPIFKREVAYASRTGTPLSILVIDVDKFKGINDTWGHHTGDDVLRRISQVF
YDNVRSSDYVFRYGGDEFIVMLTEASGSETLQLAERIRRRVEKIKMQSPTGDAIPLSLSI
GAAMFSGHPDYEHLIRNADEALYIAKKRGRNCVELWKPTA
>A0A738ADH8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Abortusovis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNYL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELYK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYSSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVALLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A891SQW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H-|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2N3PBT0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S06B 330|TrEMBL
MAAAVTDRKHRLMWGSDLDLYSQLSSQWVCSMPQQPPSAAPSRLLLPFACARPRRTVVLC
FLAAFAITLVLAGRQYYQLQQHELEVREHNLQLQALAIETLIFSGKSQLQFLRHLAERVL
IEGHSQPSMRQNDAIAAAMRNSQQPLWGLPVPKSDAPVRALGDALVASIPGLSREPQQLV
EDLHLSRAMSQVLPAQFQGETNLSRILFLTTSGIVIAYPAVRDAQLEPILRKLASSPLMQ
LNRANIEDLDIVFFPLPGSNLGSMPHLLLSTPVYLNAVMRGAVIYDVPQTKLQNYLYQTT
ESDELHTLIDEDGSLVASSDQSFKPFQGNWLNTLPTARKRLSVPMLFQRDHGTLNLEQGY
LQFRELQGIDLILTNYISASDLRAAVNAQIDFLFLGVWALLGLLMFLTLYIVDRLFKGQL
RLNRQLREMGLVDGLTQLANRRRLQSDFGGLLQRLREDQPLALWMLDIDHFKSINDNWGH
SAGDEVIKHLATLCRALVRPQDLVVRYGGEEFCVLMPDTSLADALHMAEQVRAATAKSVC
VPDAGTLLAGAPSLEIRLTVSIGVAELRVDGCEELEDLVATADRRLYAAKKSGRNQVVNH
D
>A0A3Y7AJ05|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379VQ13|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
TLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379W581|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAQRKRSPHWDARDNFQRRRSAIKMAVLSPHGAMMREPQTISSSA
>A0A377PIH3|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MSSNNLFFRLLSQRQDVITVILFVISAACFTLFYYKTETTVKQMEFLLKLSSARSDFLSL
SASTFYNIDNRKTNERLKDSQLQALQWSYSNYINLLHSFSIPKGLKESEETASNELFNRV
INARHGDSGTMVLPSNTQNFRAIIEESLEEIKYTFHWQLILLILIPFLIAVIRTLHGLYY
IDIFDKMNKDYYMDFLTKAYNRRYIPKIKKRAGLDYVLAIDIDHFKQINDSYGHDIGDEA
LYKCTKIMQGNIKASDIVVRMGGDEFVVFLFNATLQDAKHVTEQILHDINDEKLYISESV
TAKMTVSIGVAKFDNDISTTMKLADVNLYESKSRGKKQFTF
>A0A3S4M180|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGPLWRRRICGDYVRNA
GRQRDYRHVASA
>A0A1C5WHA2|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MQTIKKNKNIIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREVKLE
ITGNQNDELIKYLDDILLGLRYQDGHYNLVKLNDEEYQGKLKIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAIKIRTIELLSALDMLTLVILVIMQTL
KAMQMAMQNRLLEQKAFVDAPTGLPNKNACNELLNKKDIITGSTACIMFDLNNLKTVNDT
MGHSAGDKLIMNFSKFLRSVIPEKDFVGRYGGDEFIAAIYHTNEAEIKEILKGLYREKDR
LNSYENQIPIDYACGWALSSDNMSCTMQMLLDDADANMYKNKQLCKKYN
>A0A509DUS3|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MTFVITTGYGIYHVQFGIVLIGYLALASAIFCALTMWQLVRSNPLPVNYYGVVLCQFFAL
LLTCYFYGIRGLVLVTPFVSGVFFLFPFRNALWLSCFFVGFALIASYPSIELKLYIRLAV
AQIITLFFTIAFSHVVYRQQALLEKEAYYDYLTEVLNRRGFFKWLTSELQSIESTNSDLA
LFYLDLDKFKAINDTYGHPIGDKLLVAFANRILSALRHEDLIRSNLQVCNFARIAGDEFA
LAISQLHSKEAAKTIATRIMQAIDQPFRFEDVVIHVSMSVGICFASQSKFDLNRLFKNAD
SAMYFSKSSGRNQANFYLESDQPSP
>A0A447MTS2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MDWRVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYN
RKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIR
KSDLRHSPRRR
>A0A6G4MMJ2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITASAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLTGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A8F7IY62|diguanylate cyclase|EC 2.7.7.65|Staphylococcus epidermidis|TrEMBL
MFEAIIYNISVMVAGIYLFHRLQYSENKRMIFSKEYVTVLMTFVSLLLAAYPIPFQNEYL
VHLTFVPLLFLGRYTNMIYTLTAAFIVSLVDVFIFGNSIIYGITLIVIAGIVSAVGPFLK
QNDIISLLILNLISIIILLFLALLSPIYELVEILVLIPISFIITIASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNEVSSKAEENKQSLALLLIDIDGFKDVNDHYSHQ
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIRDYTLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTQEDRKSQRKVFKDADDMVHVAKSEGRNKVMFNPIVKL
>A0A8F8D8F5|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWASLNITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSTMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLIHGEINTYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITKGPLPARLLHLAIAADVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A7T1R2C3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWLLFSWDAISLTYTTINIIEAGIGAVLLRKLLPWYNPLQN
LNDWVRLAIGSALIPPLVGGVLVHFLVPSAEPLRNFIFWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVITLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLVFL
FTIMMVSLMMARNPASMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQALTFQQLTWPEDLNTDL
EQMEQLVNGEINTYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWSLWHDAIV
PEDRTHAEQVLRESLQARMPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEAELLHALDRRIFSEFFRTYARQVAAKGMGVALPLSEAGLASVTLV
DELLDLITKGPLPARLLHLAIAVDVLSNKDENVQQGLQKLRHAGCRVVLTRVGRDMNVFS
QLSAHTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A0U5IDR3|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MEMTTLLIAGLAISVATNIGMATVLFTRRTYPGFGYWVLGTFCRTLGGILMLSRGELSPW
LTVVLANVLLMADLTFYLRGLQLFRDRPTDLPTEIGVLLSFGALLAWFTFSVPSINVRVV
LFGVYSSAVQLWALRVLLTQRPADFGSGDRLQAFTLGIMTLAELTRALYTAFFAAPIGDF
LAAPPTQAVLILWGMMSVLLLALGQIIMNAQRIEYDYHLAQRRLEQDLAERESAAAALSA
SETRFRLAFDNANTGMALVDLQGRFLKVNDRMSAIFGYPMSALEGMSVNDLALPQDAAIS
ADFIARAVCGKADSATFEKRYRHRLGQIIYGQVSSSLVRDPAGEPLYFISQVQDITERRE
AEEALRRSHLDLQRHDAQMVALNRMNERLLSCEGRAAAYGIFADSAESLFGPHGGGLVVS
REQSNGLELVASWGERHGLRPRFSTGDCTAFRQGGIFTVSDPRGCRGCTRFQGLPQSRYL
CIPLMIQEQPLGLLQIVASDALCDGGFAELRTLAVTVGESIKLTLSNLALREALREQAIR
DPLTGLFNRRYLEETLPRELARCQRLAEPLTVAMLDLDHFKGFNDSYGHEAGDLALSSVG
RLLGEWVRESDIACRYGGEELMLILPGTTSADARGRLDALRLAVMSTRLRCQGSVLPGIR
VSIGLAAARAHEIEATDLLRRADVALYRAKEQGRNRVVDFDG
>A0A2S3U7G2|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum subsp. plantarum|TrEMBL
MLHLLTLSSLGRDLFNIKMLIVVLITIGLITLMTILTYLLEQQVHRCQNRYWTIVAHGAE
ALSVLISMILLRQIFITLNSGSIISWTYATVQLTILLFSLNTMRNLAVEIINLLMPLFIY
GQTIWLGHSTQYLPVFLAMAIILISTVVYITHNYQELHAIQWKYLLFQILYSGTWWGVIW
SVHPFKLSHTLVIILAFVLYMWLIRLAVNRVQKFFNKVLTFDQQVNYDELTGIRNRASFD
THAREVFAAYQHHQMGPVTMVMFDIDHFKAFNDQYGHLAGDAVLRHVAHFVELELNQRST
HGQIFRYGGEEFVIIFRGISALETGQIMRTIQRKLKTVPIKFNAQTLNVTVSIGISELQP
TDQTFTDWFVRVDDYLYQSKQAGRDQTTVESQLLTD
>A0A7A2WXL0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLFDNSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSPDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMFNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8G9AV59|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDDELCTNVQGNLMDEMLITIIQGHAQRLGMKTIVGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7L5V5B8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9EAW6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPAFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKVPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A831FF44|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHHHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7U4XS93|diguanylate cyclase|EC 2.7.7.65|Clostridium sporogenes|TrEMBL
MLYVFIIALFLIMIIYENIIIINLRKDIKKLEYSKNMMYNMTKNINKQKTIDKVYEIMLK
TAIDIIPKATQGSILIMDKEENFNYTAIIGYDYKLKNIKLNKKEVYLYKINGFKEAAIIE
NPIKLDEKILNKEKINKFRQLEALNISCIISAPIYIDNKLFGQINIDCTKENYKFKKEDL
ELMDHIKDELQLIIKSFMVKEELIHKANYDELTKIFNRRYFNEIMKNEIKESNKTLVLID
IDNFKTINDVYGHNTGDFILRVFASLIKTYLREKDLFFRFGGDEFIVLFNDLDDKSVINF
MENIREKINKDKIKGIHVDFSYGIGKFKNYSMENYEDIINLADKNMYINKNKKIIV
>A0A8G8PHC6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A8H1XD63|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLMQIADEALYIAKRRGRNRVELWKASL
>A0A8H2A386|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
DFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNT
VSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVD
KFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAE
RIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVEL
WKASL
>A0A2T1MEU1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRSDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377FB40|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDNFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
ISRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A8G8KPZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRSLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A8F4SUD0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWFECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6L7A275|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
TLKQYAQKNLALTAATMTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILA
SWHYTRKDPGDTFSNFISHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVL
TGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALD
FNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALL
FLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESE
VQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHA
>A0A6D0YSI2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVHHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X1ND57|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALLFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLYIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQKNELNPKE
IYQLADNALYEAKETGRNKVVVKEAEILINRKDDE
>A0A827XVX9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNQKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A5C9AQA2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRR
>A0A855PMZ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSSQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEH
AWQIELNRRRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVE
QAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQSWFIGHSQRENRHRAVRWFTSQPEHAS
NTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSS
NPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVR
GDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGAL
FEKARPLAKLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDV
AGRVGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETG
DYDFEQLQSLADRRLYLAKQAGRNRVCASDNA
>A0A6D0FY13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H1P2L1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQPQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A379CZ09|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MKISHQRTRVALYHPLRRTASLSVLAFIFTLFSLELTRAGASLAPLWFPTSLMMVACYRH
PHKLWPSILLCCSLSTLLGCLLLSSVDDTTFTSVAINIIEAIVGALLMRKLLPNYNPLQN
LQDWVRLAVSCALIPPLVGGALVLMLAPGDEPLQTLIVWVQSEAIGALALVPLGMLYKNH
YLLRHRNPQLLLETVTTLIVTLTLSAVAILWMPWPFTCIIVLLMWSAVRLPRMEAFTVFL
LTTMMVSLMLAVHPQILSSPRTLGLSNIAWLPFLMMLLPVNIMTMVMYAFRLERKHISES
ELRFRSAMEYSAIGMALVSVEGQWLQVNKALCQFLGYEQDALLATTFQQITWPEDLDKDL
RQLDKLLRGEVNSYSMEKRYVTRSGKMVWALLAVSLVRAPDGAPLYLIAQIEDIDDLKQS
EEVNRRLMERITLANEAGGIGIWEWLPAQQAMVWDKRMHELYELPQDVSLTREMWLDCLL
DEDRYRIQELIRSTMAMRASFMVEFRIRVQSGIRHIRSHSSVVLNAQGEVERLIGINMDM
TEVKQLNEALFQEKERLHITLDSIADAVICTDVAMNVIFMNPVAEKMCGWRLDEALDRPL
GRVLHITAGGASPITVTAEGACEMAIDQDVVLHSRSGGRYDIHYSVRPLSTLEGKSLGLV
LVIHDVTESRKLLRELSYSASHDPLTQLANRSSFEQRLSELLESLPHSHQSHALAFIDLD
RFKAVNDSAGHAAGDALLQALATLMQQMLRTGDVLARLGGDEFGLLLPDRSLASARVLCG
RIVEAIATFSFSYGGQEHRVGASIGITQIDATNARMSEVMSQADIACYVAKNSGRGTVSI
YAPPNRAATKA
>A0A8H1SVZ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQARHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2Y0XLT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKG
KVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERLKML
ADERLYKSKKNGRAQISWQ
>A0A379D1F7|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MGQVLVMKKIKIATQVIIIITSTLLFSGLLYREYLSLQSYMGYVAENGKSALFHEQYINQ
RIAFRLSTLFSRPPAPIAGVGDARTLCGRLEHVNDMYGFNLIASRFPALEGTLQTQNADC
QSWVYDIGAILAIDDGIFTTSTRYIFSNYGDYIFDNIRYYLDLENSYIYSSSRINIHQHP
FPYWQNENSSRIDLQAFARGISINTRELADFFHGNSITSHIHIDQILGGKAFSMICPVFN
AGKIKGMIVTQINADDLSTAFRTASRPTLWSAMKLYVSDTTSGYGIVFHTPSLSVAPVLN
VSQRLTDALTLHISVDIWYFMLSNLWLLALYLATTLLILRYSSYQFRRHATLFYDNVTDA
LTGLYNRKLLTERLRNKIAALLERKIAITVIAIDCDGLKQINDILGHHAGDRAITLLGNA
IGRSVRKSDYGIRIGGDEFILILIDADEAKAREVVRRVTDKLLETDGERLVAFSWGGYQM
REGDSLEKAFIAADKRLYQQKQAKKASPAPRQQDQ
>A0A2X1NGA0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDLPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A376LIT5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVRLPDSYK
>A0A768ACK9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHTWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAK
>A0A2X3JG81|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSYCYQRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDA
LYRAKNDGRNRVLAA
>W7VQN8|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MVLVAVATAASASVFSHFRYVYVSVALMLVAAVGGFAGAATGGLLASLSVGIVIALGLFQ
PGPGEGWLETVAFYLPVVLTLVPPLLLAAAMERNRQHVHEIEDREAQFRTLYERTPVMMH
SVDVERRLVAVNDAWLARLGYERSEVLGRRSTEFLTTESRERAERSIIPRFMREGELRDM
DYQMVTRSGEVLDVQISAIWETDAHGQPLRTLAVLKDVTEQKRLALELAAEKERIEVTLH
SIGDGVISTDEAGRITYLNPVAEQMVGCLLAQARGLPFAQVVQLFDQESGAPLPSPVEQC
LQDREVYGVRESAALRHRSGRDYGVQISAAPIAGRDGRVLGAVMVFQDVTEARGLAQKMS
YLAHHDGLTGLPNRVLFQDRVHQACQSGRRHGRRFAVIFMDLDHFKHVNDSLGHAVGDEL
LKAVAQRLTGALRASDTICRLGGDEFVVLLSDLDDVEVDGVAEVAKKILRQVAQPCVLGG
TEVNVGASLGIALFPGDGEDPDTLMKRADAAMYRSKREGRNRYHFFSKAVDDAASARLQL
EADMRRALAAGQFIVHYQPVVHGRTRDAVAVEALLRWDRAGQGLQSPAVFIRWPRRAA
>A0A0D0LN46|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A2K4P7Y6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLQTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A376P167|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIVSRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A2X1KWC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTSINSKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLERV
AIDSKRNRSFPRWEALI
>A0A6D0IGI4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYR
>A0A1C3RBX4|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MNWTLKKNIKDSDILVVDDNMVNLKVLCKVLESNGYATRAACDGEQALEAVAEKYPDLIL
LDVQMPGIDGFEVCTRLKADRNTNEIPIIFITASDTVESKIKGFEVGASDYIPRPLQMPE
VLARVSNQLKVQQFHRQGEEEKKRLENMLAALPIPYVLSSVEDGMLLEMNEKARNAMKID
EKDVREINAVTLYKNPEDRERLLNHVKQKGLVTNQEVDFVTTEGETITTLYNATPLKLGT
EDVFFVAFNDISKRKEMEQALEVAASTDYLTGILNRRAFSERAIAERQRANRNKHPICLL
MIDIDHFKKINDTHGHDVGDEALKVLVELIGKDLRSSDALGRIGGEEFVLLLPETEFEGA
ITLAERIRERIEAYEMELPSGAKMSMTVSGGLVDWDKETSYELALKEADDLLYEAKKSGR
NKIVFD
>A0A0J2EJZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTI
FKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFR
YGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYE
RLIQIADEALYIAKRRGRNRVELWKASL
>A0A6N8QFM4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
YPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDAT
LLIIEIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAE
SAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAG
RNRTEVAA
>A0A485JIF6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLMARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2X5EI71|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNAGFISFDGKT
FVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIF
TVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGTSCLYLVRRVINRGI
VEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEK
GGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTG
GTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQI
SWQ
>A0A376JF62|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELT
EAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDA
NLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRH
VQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQM
QHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEF
VLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDAL
YRAKNDGRNRVLAA
>A0A4U9TU31|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKGEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFIVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8B4NE76|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KNYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNADPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYCYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIHRV
>A0A7L5V4J6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDSHSYGLCQFGRWIDH
LGPLDNDELPYVRLIDSVHQHMHNCGRELMLAIVENRWQDAHFEEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRALATYLAGWTRDYDTVYRYGGEEFIIIIKAQNDDEACRAGLRICQLVDNHAIAH
PCGHIPITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQSVIARV
>A0A827RTN0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQV
>A0A1V2GGA4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNLDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A109CC14|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MRISNCNLHRLVQKLGLSLIAAIIFLWYPADSKAQNTPPIKVGSEIDFPPYAIVDANGHA
SGFSVELIREVAAVMGLSIDIHSGEWNDILLEFKKGNIELLPLVALSKQRADMAAFTKPH
TVTYDSFFTRKGSQPINSIADAKGKEIIVMSSDAAHEQLAASGVSVRIVEVKTIPDAMRQ
LAQGRHDAVLVSKLIGHMVLRKLKLDDAIISGPPINDYNRKFAFAVQKGNTELRDKLDHG
IAIVRATGKYDAIYGKWFGDIEPRAEFPWRKIIWIIIIICTVLVLISIWIQMLRRQVEQR
TAELQKEVAARRVMETDLRQSYEGNKRLLDALDNVAAYIFIKDMELRYVYANKLTLELFN
CTMDELIGSTDARFFSAGTIEGFLANDRRVIENGEVSEKEEETMPKSVGKSIVYWAVKRP
IYDAAGKIYGLCGVSTDITERKRMEEELKELNKTLTDELVERRKIEEELKTYKDELEDIV
AKRTEELTEVKDRFRTAFDFSTVGVAITSPEKGWIEVNAEVCRMLGYTKDELISMTWTEL
THPDDLEADVRLFNRVLDGEISGYIFEKRFICKNGSIVFSSIFINCKRSSDGSVDYFIAI
LQDISGRKRMEEELKRLNINLENAVVEETQKRRQNEQMLIQQSKMAQMGEMISLISHQWR
QPLNAISLTVQDIKDAYNYGELNERYIQGIVDTTMGQVNFMSKTMEDFRNFFKPSKDRLQ
FNVKCTIEELVSMFEELFKKSGVDISIEAKPGTILTTNGYPNEFKQVILNLINNSKDAIS
SKHETGPQGLIGINIINNEERDKIIVLIKDNGGGIPEDIAEKIFEPYYTTKGEKGTGIGL
YMSKTIIETNMGGTLTVRNVDGGAEFLITLGISNFECVSPPS
>A0A3P5X4I6|diguanylate cyclase|EC 2.7.7.65|Filibacter tadaridae|TrEMBL
MERLFKDLSADLYRSFIGDNPDPIFVLDEYENILETNLAVTKLFGYSSNDFLEMGYKSIL
IPNSDYDVDKRVRGESSAYRATAYHKNGQLLHLQVKYLPVLDNQQLVGIMIVIKDMTDLI
RTRTALQETSERLRSLFESSADAIDIIDLNGDVKAVNPAFEEMYGWKEEEIVGRPMPTIP
KLRMKEVNEKRKRVTDSYIKGLEVERLKKDGSSITVSITISPLHDEKGNVIAYSGISRDI
SESKAIEEALIRSEEKYRLIADNMTDLVAVINENGIVNYVSPSFLPVLGFPPEQFEGKQA
FGNVHPEELHEVRGKFYDLFRTKDGCDMEFRYKHNTMGWIWVEAKGSYFIDEEHGKPFLL
VVLRVIEEKRLLREELKSMAFHDELTGLPNRRLFQEKMHQALKEAKRHRRKCALLYLDID
KFKWVNDHLGHSTGDKLLKQFSERISLVLRDSDIFSRQGGDEFLILLPEIEDEESVRLIA
ARIMESLQQEWVIEGNAFTTTSSIGIAIYPKDGGDTDKLLTNADKAMYEAKKSGRNTYRM
YSQVSSDLKN
>A0A379KM96|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MMIAHTPTLFAAVALVATILAFCLLLVGQSNRQDNLWLTACGLLAHALAYVCYTVYGHAP
LWFSYGVGNSLLSLALAFYSASLFRVREQAVPWRQVFIIPACMLVGLMLLLDTVEPRMLL
ATLVLMLQCTLILYWVRRHVERPGRAHLLLQIGALVSLVGLGMRALAVVNGTAVEMRYDT
SNLKQSISVAIGTVTVMMYSIGLVLMAKERSESRLKHLALRDVLTGTYNRRAILERFACE
LDRARGERSSLAVAMIDLDHFKRINDLYGHLAGDEVLCHCVRQLEQRLRNGDSLGRYGGE
EFLLLLPRTDRDGAMAALQGLREAIALSPAHFAGDQITLRFSVGLWCGVPGPHDTTASLL
AQADAALYQAKAAGRNTVHMAALTAAG
>A0A518HV74|diguanylate cyclase|EC 2.7.7.65|Stieleria neptunia|TrEMBL
MTHSQTPFEPQNPTFNAAVPAAGGLSNSSTVARGTANCVTNLLAKLQIASEAVAETPAER
PEKDAENRLAVVRLGIATSLFYALRTKHPATAAHGLRVALFCSSWAEQMGLDHDLRDRIE
VGALLHDVGKIGIPDRILRKPGKLTVDEQLVMDTCPDVGCDILQGCTADPDLLDIVRYCN
VWYDSRRDGETPRGEALPLGARMLAIADAFDAMTTEHVYRPAMSRDRALAELVRGSGTQF
DPDLVHDFSRLLEARPEILQGSMVHRWLQQLRPEDSQAFWTGTANVAVGKSHRTKEVVRR
ETLFNQRLLSTLKDGVAFTDGEGNVSQWNVAMERLTDLPAEAIIGKQWSAAALRMRDTDR
DRDDETICPLQECFRTGEAVRRAMIIEAVGTDPVSVHVEVAPVHGERPGSHGTVIVVHDL
SDREHLERRLDTLHQQTRLDGLTRVANRAHFDTTLEELVAATAAGGPTFALVICDLDHFK
RINDTFGHPAGDEALKVFANVLRSQSRDGDLVARYGGEEFLLLANACDNATGAKRAEVLR
QTLESTPIEALGGECITASFGVTEYQSGDSAETVLARADRALLKAKDNGRNRVVQLGLGK
MSEVAEPAHRAGWFDWLIGGDEAVATKVDILTPVPIDLVIEKLRGFIADHHAEIVNVAEN
QLSLKVVSGSSPGGRRRVDHKISFHAVLTLSEAQKDELLTENATPGCSTKVHLELKPIRN
RDRRRRELKDAVQQLVASFRCYLMGEIINRVD
>A0A088T1Q2|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR1|TrEMBL
MSNNQLLNRRWRIVSIMFIIFFIAIVGQDVLREVFVFKQETNMIIDELNRDIHNETENNV
QLIADDFNYVIDNLHDDLLLHTEKNTEGLFFASNTFLLMNPTYTDSEIIDGISEITSEYS
ALDNLHNYFVYDLSGNIHYNGETDSFDSSSMIAEEDYFGTKYIEEFIQGFDQDDKFSVEY
YNIVDERVVKFVLHGEIIEGTDLIISNVVNMETYSLEKKMNRLRSFDQKYSSITSNLFIM
DFDGTILYHINPEYIGLNTTTEDQVLKTFIDKVTEYTETKSNGFLDLELYNSEDEVEDYI
GYLQVISEWEIIVGSNVSESKYNDIIDNYTESNYQLMLTIKIPSYIFIALFSFIIFAYLS
QTIRKSQIIVQEDEKLYRKFANLTSEIILITDKQGEVIFTNSLGNKAIFGKRNIDCKVFF
DQILVEEEGYFVLYGYTEDFFVKFVTEAIEYNNQGADLYIISDVTEKIKTERKLEALSLV
DELTKLGNRRMMVREYNEIVLPHVKTGSDAYLVMLDLDDFKPANDIYGHSYGDQVLKNVA
SIFMNNKDENIFIYRIGGDEFALIFIKNTEDEVIEKLKKMQKEVEDYPYTKSINVSFSAG
IKVMKINDKRRRFSDYYDQADKLLYKSKKEGKRKISI
>A0A352MRC7|diguanylate cyclase|EC 2.7.7.65|Escherichia sp|TrEMBL
MRNYFVPARVVNLCFVFVLVSSTLLTWREVVVLEDAYVASQRNTLDKVSSALDRQMEIGV
NALLFFRNAMRAAVETPLASDVLKNVQVEFAQQRHQPFWRISVDQRRTLPITGVSDDFVA
RHPLLSRDDPQMHNEMTAALEVGYIMRLATALPAMPKHAWYVSRAGFFLSSQPSAASAES
VTRYESLLAEPWFTGQSHHANRFRGVRWFTSAHQTDTQASIVTVSVPLDDAQRWLGVLAI
DYAFSSVKTLLEEALRDEEQGEYQLYNNQLERVVTSLPAGVKPRAFTPAQRQALMQAIAQ
SNSGSLRLGLSFVVWQKLDRFDGLLLRIHTLREGLQGDFGTISIALALLWLLFTAMLLSS
WIVIRRMVNNMYAMQHSLQWQAWHDPLTRLLNRGALFERAKALAELCQQQHRPFSVIQLD
LDHFKNVNDHYGHQAGDLVLTQAARLIGGCIQGEDLAGRVGGEEFCIVLPGSTLLQAQRI
AERIRERISRKEILVHNSQTVRISASLGVSSAEPSESYAFEYLQMVADRRLYLAKWAGRN
RVCAVDPIQDAPKT
>A0A485CRK0|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MLAGFAASWVLTGMPFYPYVSQRTMLATLPLISLYVLALSLLTDSIAVKLRLKSQELERI
AMLDPLLDIANRRLLEQRIAWELIRLKQHCGHSLLMFIDLDNFKEINDRFGHKVGDVMLK
TVSQILQMATRPSDTPARLGGDEFVILLPDTSPEEGRAIAQRIMDATSVVTDRPDHQQTL
TLSIGIADALPDMQEVTDWLQAADSALYEAKRRGKNQIFAH
>A0A8H9TSY2|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MNKDSTFTSRPTFKKTLRRINMISVIVTMTLIWLLLCFASVVTLKQYAQKNLELTGASMS
HTLEAALVFNDPQAANETLATLGQQGQFAMANVLDIHDKQFAHWVWNPEDSSDTLGALVS
HWLFPVPISQPIMHNGQPIGEIRLAARDTLIGHFIWTSFAVLTGCILFASIIALTITRSL
HHGMVEEIQNITDVVHDARKNRNFSRRVKEGRIEEFHRLGEDFNSLLDEMEEWQMKLQEK
NAQLMRTAMHDPLTGLANRAAFRNSIAALMTNSAAKTNSALLFLDGDNFKQINDTWGHAA
GDCVLIEVASRMIEFGGQRYQSYRLGGDEFAMVITGVHSEVDVQHISAALAQQFSRPFDL
HNGHHTPMSLSIGFALAWENNSLETLLERADHNMYQAKNQRTKTIS
>A0A0T9TYH1|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MLIAYLDALNILSTPIWVVVPKNQELLFANKEARKIAGDCHLPLMRNGRFSAHAQQQLEA
YLPALAGDDQIVEIWTIQTAGNIFPLSCRLSLTQIEPYGDVIVFEGLYISEKVLAQPNMG
QLCSKPYRRDEQGFYEQLFNTNTAPMLLIDPSKEGQIVDANQAATRFYGYSRDEMCMKHT
WEINTMGKDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGVRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEHSHAQSQRYGHDFSLILLDVDHFK
SINDQLGHNKGDEVLILLARTLESIIRESDIVFRWGGEEFAILLPLTNLEGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQIGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A5B9R0E1|diguanylate cyclase|EC 2.7.7.65|Roseimaritima ulvae|TrEMBL
MITGNVVLFAAGLTLAALLLALGAAVGFRMAAKRRPLDGGIDRQRLLHLLQELGTWTSEY
SGNVSRYQDQLGAISKSVSADPKASSPKVMELLEQIMRSNQDLKKRLDAAEMQLDKQTRQ
IESYLSEARTDALTGLANRRAFDQQLEEMFAAYRKGGGRSFVIALVDIDHFKRINDQFGH
QAGDEVLRQVANAIAQQMEGSYLVARFGGEEFAAIMPTPLRLAAERADKMRKAIAEEALH
ADGEAIAVSVSVGLSELRDDPTSGPPIRRADEALYAAKNMGRNRVYYHDGKAPTLLGAPE
IAVSRD
>A0A1V6HSP9|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin058|TrEMBL
MVVGGAMDIELQKLSYDDLAFEADRARRYEAHLSILMVDIDGLGLINERLGKDAGDYVLG
EVANVLRSNTRKIDRLGSWEGKDFILISVDLNVFGSIAMAEKLKRVIARHKFEWEGRPCK
VTCSIGVARGMPQNDAHISQLVATAKYAVARAISAGGNRVEYAG
>A0A715NJ72|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. CT18|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYIADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A1S7TCU9|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum CFBP 5771|TrEMBL
MEETAYRGIDRQTETGDTLRSTTQPVPGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADTDGQVNGILTDKPIGDDASILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDAEKPIATDPIFSRDA
VAARFATGFATIGDSSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLVA
LIVVLTVTGVLVTLIARHFLKPVPALVQATLRIAREETDVVTPFQDRRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEHLSTSGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQAVTDNCRE
DAGALAKRVVHAVSRSFSLEGSHISVDTSIGIACAPDHGNSATQLLQHADLGLYRAKSMG
CGFFVFYEPGMDMAAQHKHALEIDMKSALENHEFELYYQPVVNLESGRIVAYEALARWRH
SKLGIITPDRFITLAEENNFIKPLGEWVLAQACMDAMTWPRDIRLAVNLSAVQLCNDDIV
PIVDGALKASGFPAERLELEVTETAMLERDNSARALKLLKEMGVRLVLDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPENPMCSAIVNTIIDMAEQIGLKVTAEGVEDKKQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAQTGNDEYSDVGRPMQETYYPPQKAI
>A0A139DB02|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. T13-3|TrEMBL
MPRFSSEHLCSEWLAINARFTADAQRFVIDFACQHAASLSEHFYREMLADPGASQFLSND
EVQNRLGQSMQRWVAGLFAPTTEEGIFRLIAEQRKIGEVHARIGIPVHLVLRGARCLKDR
FVHLLHHASELDENTRFAATRLASDTVDLAMEIMGHAYSVSHDRNSRAEEAYRLFAITQN
IANEKDQQRAALFDWENQLMFSQAIGTLPGELPRIQASDFGLWFRHKGIHAFEGSDEARA
VMDTMEEIDNVLLPLFGTDEQNTALATSRVDLLKDLRDKVKSIRFHLGNLFEQNNELEAG
RDVLT
>A0A8B4N393|diguanylate cyclase|EC 2.7.7.65|Acinetobacter nosocomialis|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLIVECAHKIKII
KVNQKVLELFEAKNQEELCANLNLIFKKEMFEAHVHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTALLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPSYEDTWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAITNTAYTASRIGGDEFVILMPGADEANVLIMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEEMLKRADHHMYQKKKIYYQEVLQQ
>A0A7W6RK37|diguanylate cyclase|EC 2.7.7.65|Rhizobium mongolense|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAADGYQALAICERNQVDLILLDVMMPGLD
GFEVCARLKASAKTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRAETAETMGIDDLLRAGEGRPEEAGQILLVDSRANSQERIIKALKPIAD
VTAISDPQAALFEAAENAFELVIVNANFDDYDPLRLCSQFRSLERTRFLPILIITEQGAD
DMVIRALDLGVNDYIVRPVDTNELVARGLTQIRRKRFNDRLRASVKQTIELAVTDPLTGL
NNRRYLDNHLKVLFNRSMARGRPLSVLITDIDRFKQVNDTHGHDAGDEVLKEFANRIRST
VRGADLACRYGGEEFVVVMPDTSPEVAAAVAERLRASVESIPFGLKSAGQELKVTASFGI
SSRLSSVITPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A377J862|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MTLNRLLSVLVISSLVLSATILVLQVYQSRAQNEARSQLNSIMNVQTSIDVLRSRLWLLQ
QQGDETSLTEGRQASRQLRNTLEENTLSDVSQGAVPNLRHMQKAVDRLLVLAENNLSQTE
PPSSDPSHRLIASRLNMILLSMSEEVLVLHQRVQAHVNKIQAQLTIWAGVVMVLLSLSLV
FLMLLFRHRLKGGLNTLIAGIRKVQQGALDGEVKAKYDDELQIIAGELSDMKLKLSETMV
SRDALQREVDEQTRQLKAQHDELRRVANTDGLTGLLNRRAFESQVTLAMTRAEVSGNHAA
LLFIDLNDFKAVNDTFGHEAGDLLLNAVADRLRQVVRATDLVARLGGDEFIVWLNLLGDN
GNVDTAVSRIRAIIDSPILFHGEPISIKLSVGVALFPEHGRKLDELMKKADEAMYKAKEE
KYSNDLTFNIFQEV
>D4X9Y5|diguanylate cyclase|EC 2.7.7.65|Achromobacter piechaudii ATCC 43553|TrEMBL
MSSSKSALPVWKSGADQACYLSASNAQAWAAVYQSVDAYTRGQVAAVVADSAKELVDAFY
STLLADVEAGPRLSHEIVATRLHKGMKHWLLGLLCVRDQGDIEALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAERLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQSVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVTQLDDVVLPRLMMNEGDRQMSMPDQVRQLQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIAISSRQHSRFSVLLLDIDHFKAINDE
HGHSGGDHILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGQEAALAAAQKLGAEIRR
HDFTIPEVGARRITASIGVATFDGHPDYAYLIDRADKALYQAKLAGRDRCVAA
>A0A5P9FMF1|diguanylate cyclase|EC 2.7.7.65|Roseivivax sp. THAF30|TrEMBL
MSTQSAVLSSLRPMSLCVDAAGAIVSAGPTTRKVLGDIVGTPLFDMLDVSRPKGIATLSA
LRAQSGAKLHVRARSAPETPMVAQIAMDEAGGMVIDFGFGIGVAEAVRRHGLTAADFSAT
DLTLEILFLIEAQQAAMAASRKLNRRLHVARLAAETEATTDGLTGLANRRAADLTLRTLE
AGETPFSLVHVDLDFFKQVNDRFGHRAGDTVLQDVARDLTKAVRPGDLAARIGGDEFLLV
FPGLADADQLIRLCERLIGRIERERRMNDRIYAISASAGIALWHGGSDVSTEDLMGQADR
ALYASKAAGRGRVTLAEPRCQPPPDVSPKAPGNFADGS
>A0A1V6B8V6|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin140|TrEMBL
MDSFKTFDSTVISLIILIILYFNMYSRSQKVFTSYVLYRSLVLTNIIMLIVDFLCWYFNT
LPGNFNLWGNRIANYLLYVLAPVAPLLWILYTNYQIYNDAKRLKKLSLFLIFPLAVNLIF
TTVNLKTGWFYWIDEANVYYRGEYLGTLVIMSFIILGFSFVSIVRNRSIIEKQHFISLLL
FFVPPVVGITIQYFNYGVNYNWSGMMVALLIIYFNIQDRSLKTDYLTGVFNRRQLDNYLR
YKIQTSSERKSFSAILIDITKFKQINDLYGHQIGDEALQESVKILKKCIAKDDFIARYGG
DEFFLILDISDSAELAKIVKCIQQEIELFNSEKKKPYQLKFDMGYTVYDWHQKMQAEDFY
RYIDKLMYENKNVKE
>A0A7W9Y645|diguanylate cyclase|EC 2.7.7.65|Rhizobium wenxiniae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTADDGYQALAICESTPPDLILLDIMMPGID
GFEVCERLKANPKTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDVQLISRVRSLV
RLKALSDELRIRADTAHSLVIEDILKGVDGRDDIGQVLLVDGRASSQERITKALKPVCNV
VAMSDPQAAIFEAAQNSFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILLAAEAGAED
MIVRALDLGVNDYIVRPVDPNELLARTLTQIKRKRYNDRLRMSVKHTIELAVTDALTGLN
NRRYLDNHLKILFSRAAVRSRPLSICLMDIDRFKSVNDTYGHDAGDEVLREFASRVRSTV
RGADLACRYGGEEFVVVMPDTDATASAAVAERLRAIIEKTPFVLKTAGTAIELTASFGLS
CSTGDAETPEQLLKQADQALYKAKADGRNRVVANAA
>A0A174Z2K8|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MRRYELDTSYQGNMPNEVEFTLDNRYVVKIGDERFYNLMGETMLSAFNGLVHPDDVMGFE
QFINSDMSVRYCIVRCLIKNASYRWMLLVKKRIYEVGTDRMVELVAQDIIVISNDFDMYY
HRVRKYRAIINVIDEKIFEYDPVSGMITIYCYRNNKSEIFERTSLKEWKEACITKGFVTG
DDAVQFEALCTAIASGMNNFIVKLSSSIMSKGERVDNLIFRGQSLLADGENRITVGVISE
PDRRTRTVQEYVGVDEAKLDLATGIYNKKTVTDMITDDINKTAVSDRNRQMFLMILDIDN
FKSVNDSYGHYFGDEVIKAFADSLKLSVGGRGIVGRIGGDEFIVLIKDVTIEELRIMLKA
MRKGLKVSLAQKQPEYMFSTSIGIAQFGKDGSDFETLFKIADAALYIAKEKGKDRYIIYD
YNKHGDILADMKHDIAFGSGFMKPMAKYELATNIVMKVSLGMMTVKEVLSELTDKLNIHG
ISIYSGNDMECIYSTGHYKNNVIEAAYVNDDKFVNHFDEYGVNMVNNIASLTIEFPEVFR
KLRDNNICSFLQMKADGADGKEYMVEFDIFGTNRRKWSDTDVIMLRMVVLGVVNAISGQL
TD
>A0A8G0TCW7|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MKDSSATVSQLALLQQKLHSAKLALDEVNEDRNAKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHNLNTFERVDEALPELVDVERLLKGQYHHVMVQLEESRTGLSQVIRQIQRVNSAP
EKLKKEVNYFKQDLAKPFHTVWEYIPKVKQIIGFYETILQLQFNESEKLDVLPKHRQLAH
ELAQMISEIEFRKDQRDQVLVIKEVLSSEIEVDSLLEAYQTILALLLDNIAREKSASQEF
LFALNDALAAVREVVSESYNHNQRSFQLKTQLNREINTRVDNAGEIIIDVEDVVDLKAQL
TEQLNSIRSALARKEALEQREQALLRKSMETMRKELNELSNEANTYKERLFEQQKLNLLD
SLTQLPNRAALEERMDLEYRNYQRHKSPLWVAVADIDHFKTINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLLLPDVAPADIAQLLNRVREKVKNIPFKFKNQRITVTVS
IGAAQVMGSELIHETFERADAALYKAKHESRDRVVIDV
>A0A1C5XQM3|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MPKYMQKKRIFPACLFLMFVLMILVIGKETEMTGRGETQKIWNLSDGWYYLKDGERTEVT
LPTTLQEDPGTVLELYNDTVTDENRDMVLLTWGAPYHLQVQMDGKTIYQYRDYGFKRNLQ
MARKLECRVTLPALHKSSQLCFLYTVPKSGVCKLTPVYMGTSEAIFRFQIMNAAPVFVIV
LGMLVLGIFAIGIYAYLRARKMTERRFASVGLFLLLCGIWCVTDSSLMQYLSHYSPAINE
ISFYAFMLMSVPVIRFVRETEGMQKYKSISVLIALFYLNVILQSICTYWFHIQLIHMLMI
THLLLVGGCILLSVLLYREYKAVKNRQIYSILMAFGILAFVGVGTLVLYWFFGITGYDLI
FEAGIVVFVSVLLWSLGRAMVENMRFRTEAEVYKKLAQEDQMTGMKNRYAYEKILEDLED
GICNWKNAVLIFMDMNHLKQINDIYGHGAGDELLIGAAQSIQKAYGSLGYCFRIGGDEFC
AILPEIKISEEELSCRLDAAVEEYNRSNDQKLSVARGFSWLQDSRGMRKSISDWKFEADQ
NMYSNKGWYKREEVQEEGTHYEI
>A0A448W457|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKNHFELKNYVMATGVFILAVIAGILIFFECVQRAVQVNSQNTLKINVQRQSEHLRTIL
DINYQYLNEIASAMGKSEELFSEENKEQLISIYEKTDLERVALIDKNGDAYYDNGVTKNV
SHRRYFQEAISGEQTISDPLESSVDHKVRVVLGVPVYKDYKVIGVLGGSCNVTALSHMLF
NDLFDGAGNSLLATSDGEIIAFDSGSASGTEITYGINLFKYYGEKNLKGKHTLQDIQEDF
KVGERGLVKLSLKERKEEDRYLAYMPLGYNDWMICYAIPVKSAQQAYEFISGYEILFMGS
FCILVLLLLLYIVVRNNQEKAELVRSAQKDALTGVYNRENTQKVVDAILREKAPEGFHGF
LILDMDHFKEVNDVYGHVMGDNVLKMLGGFLKEQFREQDVIGRIGGDEFVILLCNIGSRE
NMESRIKKLHEKLREIRMEGMGEHTFTFSAGIAFAPQDGDTFMELYQKADFALYQVKRSG
RDGYRIYK
>A0A0J6BU42|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MAFKPRLFGLLLALAAISVGVGFVNALHAGYLVQRAQVIQNSLTSGQHYAEKLAQAIDLY
LDALHQQLAVMALPLEDSARRQAVLERLRQQADTLDALAVVDAQGRVLQYAATEAGAALL
QGSGEADQVLPAQAGLPARLVIAQALASGDERLLAVMALERGSGLDRLITGQLGAAAYSV
HLVSDEGMALYGAAPPAELSWARLSGGSGAVLRESPSGAAEVVGHAPVGQGRWMVVLRQP
LAPRLASLSLVWRESLARATPAALFMLLLVGLLAYAIARPLTRLARAIDRGSEAGARRTR
PWYFEADRLRSAALAALGKHQTEVQRLNTASMTDPLTGLANRRALQPCLEALADRRQEFA
LLALDVDHFKQINDRHGHPAGDAALRALAETVGGCIRPQDRFFRIGGEEFLAVVPGDIQA
AGQIAERIRQAVAGQAMPAGVGSMTVSLGLARWPADAADIPAVLARADQALYAAKQGGRN
RVVRWDECKPGPA
>A0A1C5QRT8|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MVMENVREEGLKVLEKDRSAEFSSFYDRFKKCGFSTDGTEAWLLLQYLQISYDLVRYVDP
ITNKVIHIEKDGKMWESETACSDIWNCLEKCSNCISRLSMQTRKRMTKLEVAGDDPYQVV
SMYVEIDGKPCCLEMASRLDGDFMPDGYSRDEILSSVRIHKEKVYIDPVTGVYNKRYYVE
KLSKMDNAAALMFADIKNFKRINENFGHQAGDDVLRQVAGVLRDVAAGKGDVLRYSGDDF
VTVFFKVTEEELSEIQKEMCRRVEALRFPELPGVQLKLVTAGTSIPGRVEEMLEQVRI
>W7WU78|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MISGNYPDSVERSSELLRLALPQMAKHSVALHPINYAVWYEYVSGRSGDLKAEIERLTAD
GRALTEADVARLFKAYVAPVGLETSERVAENARRILRSMEQDALEATDRTSAFDQSLSQW
QAELDREANGGAVLQGVVASTREMSEAMRQLQSRLDVNQREIAQLRAEVAAARSEAQTDS
LTGLHNRRSFEQHIAKFLADREAAMSLVLVDIDHFKLVNDTHGHLFGDQVLMAVARVLKE
SVRNDDLAARIGGEEFALLLPSTPLKGAVELAERIRTSIANSRIRRRNSEQQVGQITVSL
GVADLWPSDNGESWFSRADEALYASKREGRNRVTAPSLLARHAVTGGVNRS
>A0A0D7UUZ1|diguanylate cyclase|EC 2.7.7.65|Halomonas meridiana|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRAALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLERASGLEAGRDSLTRL
LNRKFLSVVLNREIEIARHSEKCFALLMVDVDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVASATE
>A0A378IZH7|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MIKPKLPKNEAERLHALRALQILDSSHEERFDRVTRMAKRLFGVSISLVSLVDENRQWFK
SAQGIDASETSREISFCGHAINQEGLFIIPNTLEDVRFIDNPLVINHPNIRFYAGYPLKL
RQGIVLGTLCLIDSNPREMNDEDQQLLKDLGGMIEQEIKSIQLATLDELTMISNRRGFLT
LADHTMKICRRHKKPMAFLLFDLNKFKIINDKYGHHEGDFVLTLFAQIMLESFRECDVIA
RLGGDEFVTMLVDCDDNEINTILKRFKTNIKNANTTLHKPYNIEYSTGVAHFSYDTDKSI
DEMLQEADTAMYEDKQGKAR
>A0A1V5W442|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MALFYNNQIELLKGIAIFQDLLEEDLHFIASHMRQITFKAGDILFQEGDPGEEMFVVIKG
GVSVFIKDQEEQELVLTEVREGNYFGEMSIIEKSCRSATCRATEDTLLLALHADSFSKII
EVIPEAASSIMNRMLSIIVKRLMRTGAFITQMVQYGEESRKRAITDPATGLFNRRYLEES
FEGLVAKAIGERQSLTFVMFDLDRFSTLNARYGQEFCDNLIVKASYVFREVFTKDDILIR
YGGDEFIFIFPDTDKGKAQIKCDSLCEAMRNMKVEGHDELRLTCSMGFATLPEDATSPEE
LKDKADKALYMAKEKGRDRAMPWNG
>A0A1S8RA18|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MFNYIIFLAMFLTAFVSAQLCIFLFYKKRRIHLNGLLGVILCVFIYSLFYSFELICPNLT
FMKLFTGIEYIGIASIPAFWVIMALEYTNKSRYITKKLYMLLFSLPMVLVALNITNDYHH
LFYKSYTVVIADNLYIANLKPGIVYVICVIFVNVCFIVGNSLYLIFYRKENSLYKKRSFK
IMLTSFIPWIGYWIYMSRITSIRIDIVPIFMGVFCLIYTYALFKSNIFETATIARHVVFD
NISEAILVLDQENKIIDMNNIAEKIFNIKSKLAIGQDVCTEFKEYQEIIKYIYEEKETSF
NCEIKIKNKLYYFKGKLTLINNNRGKGKVIVLSDNTEQVLMIKKLEYYGITDVLTGVYNR
KYFYKIAKEKIEACSDKKHMSLLMMDIDKFKIINDTYGHPTGDIVLKKVMNICKELLGKK
YYIGRYGGEEFLILLDNANSEKALEIGETIRRRIENLEILHDNKCIKITSSFGIFTSVRE
RDLENMIKFADKALYEAKSLGRNRVSIKMGNS
>A0A1S8SJJ8|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MQDYEKLYKSLKIEYETYQKFSEQHIQELNEKNVRLEKSIDSLSNIIEVSKYINTFFSSD
NLISLINDMILGILGVTYSTIFMIENGELIVKASNIENMNINLTSKEFVHINKGEEFLVN
SRKPLKQTGEHKIDIHSIMGSPIKLREKFIGYIVVEHNLYKFMNIELKLFLRSIANQIAI
AIENSLLYKELEKINQRDPLLGIYNRKYFFEFLEKNENKKLNDKFAIVMIDIDDFKKVND
TYGHQFGDKILINTANIIKCGIDKNDIFARYGGEEFILYISDFTSEDNVYGKIEAIRRTI
EGSKINFNGRDESITASFGISFFPLNGTDLNELISKADDLLYKAKKSGKNRVLSGNIFKI
>A0A5S9PVP8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MEKGIREYFLIWWRQPFEFDWTARHFRARGVLRVHQVFFGCFCLLYGLTALLTMVWGYAD
DGPVGGRWLVLIVAVSSAVLGVLWIFGPWPTERQSAAFVIYADLAVVTVIACYEDAFLAM
PGLALLAANGIYVVIAHGPRALLLHLAFTVAAFAWLYAMSITQGTAAVSLITVRLLVLIP
TVVGVPVIVHSYLLALRIGAVDAMYDPLTRLLNRRGLEDEVDDLLAADGGQVGVLAVDID
KFKAINDRHGHEAGDRVLIGVANAARDAVVSAGARAVIARTGGEEFVVVVDDRVVDGRAA
VALRVAELLHEKVARCDGAAAPTVSIGAVTAGTRGDVRRTVRELIERADAAMYRAKNAGG
NRTVVAGDSVAAGE
>A0A554WPR6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MIVSQHSRADFDPVVEWQSILTKTPPAIAQRISALAHDLGDELAEAFYTEMLTHPQAKLF
LDADIVHQRLHASMRRWLAELFEPHPPEALSAIVAQQRHVGEVHARIQLPMHLVARGARF
LKGRLLSRLLHRPDVAALDAQQTEAALLYVNDLFDLALELMAESYVRDTQRVARTEEAFR
LHALSQNLQVERERQRFLLAAWGQEVLFALHRGGQPLVLPTLRGSEFGLWFLHKGDNLFE
GAPEVEPVHASLDRIDNALLPQLQVQDPQRQPVLITELQAALGNLQYLVQVLFERHIELE
SGRDALTRLLNRRFLGPILGREVHLAQQRRIPFALLLLDLDHFKLVNDQHSHDAGDTVLQ
QTALLLLNHVRASDFVFRYGGEEFLVVLVDVTPEQALRHADKLCQRIAEHTYELPGGVAL
NLTASIGVAPYCGHPDYQYLIHQADTALYQAKRSGRNRVVVAGDAAVGPPTIAA
>A0A7Y7I7L8|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SG517|TrEMBL
MESLIEQLSGSVASARTLEDLTRPMLEMLEAVTGLESTYLTTIDLDKGQQHILFSRNVRQ
LSIPEGLTVPWSDTLCKRAMEEGRTYTGDVASCWGDSGAARELGIQTYVSTPVKTESGGL
FGTLCAASAEQHPLAPHAEPVLQLFARLIGQQVERELLYRKLEKAHAELVTLAATDALTG
LPNRRSLIDGLRRLLAQTQRDERSVLVGFIDMDGFKKINDTHGHDVGDEFLVAMAGRMSA
SLRAGELLARSGGDEFVVIGAGPAIGGATTAAARALADRLSECTAGELRLKGTTLAYAGA
SVGVVAVDPRATTAAQALRQADEAMYAVKRSRRGMQHRASEAVSG
>A0A1J5NBT2|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MTETSLRKQLEQARERIEELEEELAKAAKATCEDRYRMVFENAPGGMAIITEQGNILLSN
AEAKKFLGLSGADGERNAEDFYVNREDRNRLLALIRKKRHIRNYPVLMHRLDGASMWASL
SARAIDYGGEPANLVSFTDITEHRRALRRLELDELRFERLYALSEMTQHTEKEILDFALE
AITEVTGSEIGYIYRVSEDQTQLTLHAWSESVMERCSIKDVPEVYSICETGLWGEPLRQG
RPVITNDYPNLKKKKGYPDGHIPVRNHLGVPVFEENRVVFLAGVGNKPGDYTEDDIRHME
LIMNGTWRIIQRRRSRAELAAAHAELEEKVRRRTDRLQQVNRELAGLNLTLMSKDQEREQ
ARMELLRYQRIIETNPDLISLIDSDYRYVIVNESYTHIFGLKRESIVGQPVGILFGSRYF
EERFKPAIDRALKGETLTEAAWLPLPDAGERYMSITYQPVRVQGDDAEYVSFEARDMTDL
KRSEEDLKAIAERLDLATDAAHLGIWEWDLRTDDLLWDRKMFDLYQAEPLPPKELFDFWR
GCIHPDDLAATEQQLARSIETKEPLYLEFRIVRADKAVRHIRIEGLVQVDDKGMPIRLIG
ISMDVTEQRQMEDELRTLASTDPLTGASNRRQFMSRLGEEFERCKRYNTSLVLLSLDIDH
FKRINDTYGHPAGDDVLKELVALCRSTLRTTDLFGRVGGEEFQAALTQTRIGAGENTAER
LRRRVEQCEVRTHDQIITFTISIGVTALTPDDESIEGLLKRADDALYQAKRSGRNRVIVL
>A0A1J5MSK1|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MDHPAPHRLKARYKALYAASLLALAALLCVCFGMVYTLRLDPGGDHARLMQLAYLCMVAG
FFVLAAQALLVYKKVMACMGQDAARADEMAEQMERLAVLDSLTQAYNRGKFEEIAAQELG
NVRRYALDLSGIMLDLDDFRSINQAHGYSTGDRLLANMAHFLNDKLRNNDFLFRWHGGKF
IILCPHTDIDRAAIVAEKLRVLVGHKIFGGKIRVSLSLGVAQAGEDDTLESFLQRLQSGL
TASKNGGRNQVTVVRAQLSPR
>A0A5J0IGW4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hvittingfoss|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A087CR86|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium reuteri DSM 23975|TrEMBL
MSVILIVDDDQAIGEMLSLVLENEGFQTVTCTDGLRAVEMFPTVKPDLILLDVMLPGLDG
TEVARRIRQTSNVPIIMLTTKSDTTDVVAGLEAGADDYVPKPFKVAELLARIRARFRIAA
PMSATGGSETAANAANVNHVERGGIVIDRLEHTATKDGRDLGLTPMEFELLFVLAAAAGE
AISRSALLHDVWGYESSGDTRLVNVHVQRLRAKVEDDPENPQIIQTVRGIGYKFVTPEG
>A0A1S8TMT8|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MQNYEELYNSLKMEYETYQKFSEQRIQELSQKNVRLEKSIDSLSNIIEVSKYINTYFSSD
NLISMINDMILGILGVTYSTIFLMENDELIVKASNIENMNINLTSKEYIYVNKGEEFLIN
SEKPLKQTGEHKVDIHSSMGAPIKVREKFIGYIIVEHNLYKFMTIELKLFLRSISNQIAI
AIENSLLYKELEKLNQRDPLLGIYNRKYFFEYLEKNESGKAKDKFAIIMIDIDDFKKIND
TYGHQFGDKILISTVSIIKNGIDEGDILARYGGEEFILYISGYENEDKVCEKIEAIRQNL
EKEKVTFNDKCKSVTASFGVSFFPLNGTDLNELISKADDLLYKAKASGKNKFMSGHILKM
Q
>Q31XE1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5B0TAB2|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAIDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLSVLLSLPV
LVVYPLLFAWVSYQTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A5A9CJ71|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAIDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLGVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A0P1FAE7|diguanylate cyclase|EC 2.7.7.65|Shimia marina|TrEMBL
MRRFAKLTFTLLFGLSGLAVAIFGVLQISLPIVERLMESDIRKHSELWHRRVILHLEDPD
NSFIAGGLTSEDISYLQLLPEASDVYRFKLYNSSGTVIWSTRPEDIGYLDIEHFPKEALQ
NGITSYHREQKPASEIDGLVLHALSEDVSTHEVAEIFEPVISGGAVIGAMEFYTDITDVR
KTFLLRVRVLLFALTALAIATVGVVAVLLFRSNRRQYRALTRRSAKEKDLLNEQLKLARN
VKLLGELNEWLQSSRSLDELFDMVKRFMTHLLPDSEGSIYVYSNSRDVLDGWASWNGGNH
KDHIHPDECWGLRRGRTYEYGDSEINFTCSHAEPHNDHPYFCFPILAHGETVGLLHLRAK
SKDAEIFHANRDLAQMCSEQISMAIANVRMRDELHDQSVRDPLTGLFNRRHMTETLRKAI
NDSQRSTDPFSVIAIDVDHFKKFNDTHGHDAGDMVLRAVGSVLQQDCDGDEVACRPGGEE
FTVILPNCDRETAQERAEGLRSAVENIKVRYGEKTLPRVTISVGLAIFPEHGTLPQMLLR
SADDALYQAKALGRNRVVLSDTLENGEAPGELWALPDARDQDAPDTAKDSDTTAAEPLTK
KAG
>A0A564W7L5|diguanylate cyclase|EC 2.7.7.65|Blautia luti|TrEMBL
MKKNHFELKNYVMATGVFILAVIAGILIFFECLQRAVQVNSQNTLKINVQRQSEHLRTIL
DINYQYLNEIASAMGRSEELFSEENKERLISIYERTDLERAALIDKNGDAYYDNGVTKNV
SHRRYFQEAISGEQTISDPLESSVDHKVRVVLGVPVYKDHKVIGVLGGSCNVTALSHMLF
NDLFDGEGNSLLATSDGEIIAFDSGSASGTEITYGINLFKYYGEKNLKGKNTLQDIQEDF
TVGESGLVKLSLKERKEADRYLAYMPLGYNDWMICYAIPVKSAQQAYEFISGYEILFMGS
FCILVLLLLLYIVVRNNQEKAELVRSAQKDALTGVYNRENTQKVIDAILREKAPEGFHGF
LILDMDHFKEVNDVYGHVMGDNVLKMLGGFLKEQFREQDVIGRIGGDEFVILLCNIGSQE
NMESRIKKLHEKLREIRMEGMGEHTFTFSAGIAFAPQDGDTFMELYQKADFALYQVKRSG
RDGYRIYK
>A0A239ZYS2|diguanylate cyclase|EC 2.7.7.65|Mammaliicoccus stepanovicii|TrEMBL
MIQAIIFNISVTIAAFYLYHRIQYNETRTVTFSQNYITLLMTGVSILLISNPIQLHNYEI
SLGFIPLLFLGRFTNLFYTLLSAGVIILVDIFAFGTPFLDNLHLLIIAVVIGVIGPFLKQ
SDFVCIQLLYLISIIIIAITLIFSNPDSWLNEWLFLVPISFILSIVSASVYRDIWILKNL
ISRYENEESIDYLTGLGNVKEFDRYLNHTTELVTENNQSMALLLIDIDGFKDVNDEFSHK
SGDAVLKQMSQLLINYLPHGVKAFRNGGEEFSIILMGESLDSAIKLAESIRDSVQQSTFH
LPNKETIKLSVSIGVGYLTEDDNKSKRRVFKDADDMLHEAKLQGQNKVMFNPIIKL
>A0A8F8CWL1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter haemolyticus|TrEMBL
MPHPKAALKPHSLFQLFLLFAGVIFLCCLLGIATRHLTFLASFWPANSVLLGLLIRFPQT
RHPISFIGAIVGYLIADTTQDTPFILNICLTTANLLYVITTLALYVRFSQIIRSMHHGYF
YLFLFSFCCIGGLASALFAAILLPYLDTPFALGSFWEDFGYWFTSEIQNALLLLPALISM
PNLTAFKQCLKELKDTAIQTVLPLVAVVVSIVIAYYDAGPGSLLYPIAPLIWCALRYQHF
SVTIISSISCAFIIYHVSQNYLLLYPDNYLNNTISTRLGLIMMTIAPLTVSSINKVRSKL
IEELQHTIAHDELTSSLTRRQFLQSLQILQEQAQNAGHTSAFLMLDIDHFKHINDSYGHQ
IGDRALQHFVKTTQTLLNPQDLFGRLGGEEFAIFIANTNESVAYQCAEKIRQHVSESPIQ
LEHAQVFSIQTSIGICTNTPEKNYSTEQLFKHADDALYRAKRQGRNQVVIST
>A0A0T9QL90|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MLRSMISTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNTLEANRVYAAK
LASSTEIFLRSAQKQLHYSSMIAAKHFDDQAILKAETARLKYQTDSFNSVVITDAHGIIR
ATSPDSLQLLGHTLTSPGSAEALKLRRPIISKPYVSAANNLVINISTPIITADGRYRGYI
GGTIYLRKQSILNELLGEHYYRDGSYIVVLDGDRRILYHRDVNRIGEILEPKPITEAAKK
SDNGSLMVTSTNGESMLAGYAVVEPSGWEIITLRPESSTLKPLEGLMLKGLGHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIASSIKEIPSWYFEATQLKRALLIGISLLQ
KKIGKLRFEAHTDPMTGLYNRRGLATTLEPIAQLGQHFSVIALDIDHFKSINDSYGHDVG
DEVIKQLAIQIRDSSRDSDILCRSGGEEFLMLLPGTVPDVAIQVANRLRHNVEMMVMPGI
RPITISLGVAFWNGVGTPEDALKRADEALYRAKQQGRNWVEVA
>A0A2S6R9X7|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha10_Bin1|TrEMBL
MKIEGNRPSRVGATNRVGSPNRASASAPASAGHQVQDSASIMGIPEAELTPKVRSAIMTL
MEEVASLREELNNNRGRIQHLERLADQDSLLQVYNHRAFVRELTRAISMTERYGAPSTVI
YFDVNNMKQINDTHGHPAGDAALRHVAETLVEQVRDSDVVGRLGGDEFGVILYQIDADIA
QEKSGQLAQEIANNPVPLNDTELNVKVTFGAYTFNGVEDAGQALAEADKAMYERKQKGQK
AATSR
>A0A156HJL0|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MRSALTAFRPFQPDTPLRNASTIFILTTLFYFVGAELRLVEALSLFWPLNGVMAGIFARY
VFLNRLHYYAVSYVAMLMYDAVTTNWGIASVVINLSNMVFIVVVAVLIQRDRRLMKKTPD
PLNALRLFNYCLIAALLCALLGAVGSVGIDSHTFWPLFADWFSEQFSTGVLVVPCMLTIG
MPVREFRLRLEQLLPVIALIVSVVASVVIGGAGSLSFPLPALIWCAVRYPLPVTCLLTFV
TGAIEIILVANSVINIAVATPLTTPMMFSARLGIATMAICPVLVSVSMAAINSLIRQVSL
RADYDFLTQVYSRSGLYEALKHEETHRHSRFLTVMLLDIDYFKSINDNYGHECGDRVLAS
FARQVQQVVGEDGMVARMGGEEFAVVVNSGDARHGYELAERIRTTVANHPFTWRQQTLSL
TVSIGLGSGKAEAWQLTEVFNKLMTEADDHLYRSKKAGRNRTSARVADEHITAATEHETE
LR
>A0A517QQX0|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus polymorphus|TrEMBL
MSKSQSETKTMRDFFSAREDDSSLPSCRNQTRFHHQRSHSAALSFLLIVGCLLILQWSNL
GWSTGKLGPSILLIFSALAGWTFKQPGVTYTMGMTCMGMLILHAVQGELHQQAIVETARA
TFSVGAVAQLMTVVRSIIDDRESISGSDPLTNLLNLKRFKAYVDSRSASDHPDSSPFAIA
LLDCDQFKSYNDTHGHLSGDQYLIDMANRIDSSLVEGEFAARWGGDEFAILYLSTNEEFL
VDRLRALQQSLASTSEQIENSMTWSVGIAIFSSPENFSADEMINRADQAMYAAKRTGRGQ
IHVVSDSSGDGL
>A0A517QNX9|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus polymorphus|TrEMBL
MSTSLSPNVNTLSYLNSHPMESSRLLNSLIEIVQTVENSPSGNPIDEIINIHILRRLLTA
IHFRDIQTLKHSRRVGIISVGIGSRLGWEDSELRLIEIASLLHDVGKIGIPDHILHKPGR
LSPDEAEYIASHHRVAIEILQATQASQELIQIVAQAHGVKVDTGDSNEKNSSLGARILAV
ADAFESLTSARSYRPAFDEKSALKILHEQSGKEFDRNIVAALERWLDSHESRGLHDDSAA
ESAVQANAPTTDSAKANAACFCQLFQYLHLMESLYDAFYLIDEKRRVVIWSMGAAKLFGF
PAVDLIGQPWHRSVVTADGPKPDPVEIAFQSAKSNCHTLTLKDIDGNDQEFGVQTVPILD
LNQRVVATAELICDGNESKKHRGQFRKLHMAATRDALTGVVNRGELDDKMIQVFNKWNAE
PTIPFSIVFLDIDHFKEINDRLSHSVGDRVLIDVARLIQDELYSGEIVSRYGGEEFVILC
PETPLETALERAERLRRAIMGTKIAEREDLRVTASFGVAQVEKNDDPESLMKAADKALYE
AKNSGRNRTCHRKVSAVQNAPTAEQKKQSDWIHHAEITTCVASSMLHIKLKGYVLDNMAK
ILDVKEDSLLLQVGASGLLGGWGNKQDRQPVKVRVEIHELPNNEKVSGTRRILLKTITEP
IGRPAKKETFHTRASIVVESLRSYLIAD
>A0A1S7QVY9|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense RV3|TrEMBL
MNEIIDTNVFNLAPVAMWIEDFSEVKSQFDIWRSQGVEDIRAFLLEDLSRVAACSQKIRV
IKVNARTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSELWAGKTEFTSNAVNYSIGG
KRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKELLNRRYAEGMFKHSPVSLWVE
DFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLTHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDELNRLERSALRPVSAIVIDLN
GLKDANDRLGHDAGDALLRRVGEVLNGVVTAPNHAARIGGDEFAILLPGADRQVAAAMVE
TVYELLKINNQFYSSAPLSLSLGVATSEVGETMESLVRRADMNMYEQKNAYYAALRNRSA
DNNDTTKPGSQAEASSLKRLS
>A0A554W8E7|diguanylate cyclase|EC 2.7.7.65|Tepidimonas alkaliphilus|TrEMBL
MGSPASTPQEIAREAVRLLAARRLPPTPDNFQAAYHEVAGTRPLQPFPLAQLRQIGQALP
ERTPAQLRFKTLFNRAVTRHSWDDLEKLLVQHLGAASSPPPPSATPPATAQPPDSAEPAP
HADEKAASIPISPDIAEPAARVIDLTLPLVAADDARLREMGEELVRYLRLEQHHAPTLRR
MLADYAFRLSFGVDEQLGVREALLGLLRQVLEHIDAISPDNPWLRQQLQALVQAAQPPLS
QRRLEDLQARLKDVIVKQAEAREQTVRAQELMRQTLATFLERLAQTAVSTGQYQAKFEAC
AQALERAQSLADMAPVVQDAIQTARAFATDTQRVVAELTELRDRADRAEAEVQRLRRELD
QMAELVTHDLLTGVLNRKGLENAIDRETHRAERTGTRVCIALLDVDDFKRLNDTLGHLAG
DAALKHLADVARRSLRPQDTVGRYGGEEFIIVLPDTTPDEAAAVVQRLQRDLSAHLFLHG
EQPVLITFSAGVTELRPGEPVANAIARADQAMYRAKRAGKNRVMQA
>A0A4U8YWM9|diguanylate cyclase|EC 2.7.7.65|Methylocella tundrae|TrEMBL
MTARVLVVDDILPNLKLLEARLTAEYFDVVTCTNGPEALSVCSKGDCDIVLLDVMMPGMN
GFEVCRRLKADPATAHIPVVMVTALDQTSDRLTGLEAGADDFLTKPIDEIALLARVRSLA
RLRLALDELRTRAMRAAQLGINNPLASVMNENGSGGRILVVDDRRSSSETVTGALRALHD
VELEPDALEALVEGAAGRYDLFIVSLSLNAYDGLRLCSQIRSVEATRHIPILAIAEPEDR
AKILRCLDLGVNDYLLRPIDRNELIARVRTQLRRKRYADGLRQNVEASIEMAVVDALTGL
HNRRYLDGALAALLEEAKRKAKPLTLMMFDIDHFKTVNDVHGHEAGDQLLQNLAARIKGL
IRSADLFCRLSGDEFVILMPETRLDVAARVAERVRAGVESQGIPVEARERPLSVTISIGL
AESAQDAADLLRRADKALYRSKQSGRNRVFIDAAAPVRLERMTGLRVVRSS
>A0A8G1NJ00|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MGRTGGKGLSLARRLYTSRILGLVLGLLCVSVAMYPLDPPAWVWAVMLFNALVWPHLAYQ
WARRAKVPYHAEHRNLLIDAFLGGFWVAAMHFNPLPSATTISMMAMNNVAIGGLRFLLAG
AAAQLLGVGVGLVVFAPAFVPMTTSAQLFACLPLLMLYPLALGWICFRQAYTLGLHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCKRQQSGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRMADVAGRYGGDEFCVILPDLPLFNAVQAMEALRERFSFLVYEQNPA
LKVSLSIGLAALDPAQGDATRWLDDADQALYEAKAGGRNRVICCSDDKPRREVFDSV
>A0A379YQD5|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MYIDLDDFKLLNDTQGHEAGDHLLKAVSNRLIESVRDSDTVCRFGGDEFLIMLSGRNQIF
SSDAWVKKIGKKIRERLSYPYDLGAEPYICTSSIGAYIHKGEKLSSDEIINKADQAMYIA
KKKKNAFYLVSGNYADG
>A0A0W0Z6E9|diguanylate cyclase|EC 2.7.7.65|Legionella spiritensis|TrEMBL
MVFPVVMIVLGIVFLISGAYLVNRLLQQTSHYRMQWLGYLAFIGAFILSYSASIFYGLLV
DPHCLNYFYASVFLLGATYVYLSCRLMTKTIQKMELMDDFKNRYEILRHHATYDSLTGCN
NREYLFEILNTRFQQIKMNAGSVIVLFIDMDRFKTVNDRYGHEVGDTTLQMFGGLLRQCL
RRDDLVARYGGDEFIVLMENTSMDEAKKIAENLITVTRKSFKEGTLSELNLGCSIGITQM
NHHSASVNTVIKEADLACYAAKQRKINGSVCVYSPMLATKNNAIHFSRNQITQ
>A0A6S4Y1T8|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MDKPLWVRKLRRVSRPGHVVNYCFVAVLFFSTLLIWREVMVLEGAYVTNQRNNLENVADE
LDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHEPIWSVALHNRRTLPV
YGVSDDFVDSQSSLSRNDALTGNELMAVLELGYLLRLVENNRGFNERMLYISRSGFFTST
TLPKNAVQAQTLYTHAIAAPWFTRQSQRNNPGRGVFWQTVLDEHAQNDDPVVTASIPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIASSASGNVLTLLSAREQ
AMLSYAFLHQNQGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGAFGTITIALTLMWL
LFTLMLIISWQVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFERAIATTRMCERTG
RPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQVATAIAERIRIRIYSREILLCNDTSLRISASLGVSSSDDCAGFNFENLQSTADHRL
YLAKQNGRNQVCFNDLPSCAGLRK
>A0A2H5ZZ65|diguanylate cyclase|EC 2.7.7.65|bacterium HR32|TrEMBL
MPASGPREDPGEVRRQKLRARGILVSALGYATGLGVVVLAGRLWGSPVPPSTLVELGTAT
VAAVGALYLMAVTGATRWVKGWDPHFVYLPMLVTVGLLALYMRASPETRWILVHGWVASL
ALVAGFAAFWPLVGLSALWLATYLWVAKNSPGFYLRQELVVVFAVAFASVMCSLASERFR
RQREEVKKLARQLEDANRRLAELALRDPLTDAHNRRFLEEFLQHEVGRAERTGWPLVVAM
VDLDDFKVYNDTQGHLAGDEVLRRVAQAMRSCVRRSDLVARYGGEEFTVVLVETQPEDGA
RVLERIRSCVASLPMPGAEVLPWGAVTVSVGAACYPQDGSTAHELLRRADDALYRAKSKG
KNRVEFARPLASGGPSGIPQVSFGRVSRD
>A0A811GDS1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MAILSGLTLNFFLFKYIKQIQLLDMILPFSTCVSTILWFEILLQSTSSLVATYQYAAVIF
IVLGNLCVQVHFRPSLISTAMITAAILHGIWRLNTFNEFIIFLFVYVPILLFSIYICWNN
TLNSRKNFLRALLDDWNYHTLRKLAHTDELTQLSNRRQFVYAAERRIQATADTESTSLLI
FDVDRFKSINDQFGHDVGDQVLCCIAEIARKEMRHNDMLARFGGEEFIVLLPHTSQSDAL
KIAERLRHKMEQHTIQLDHHALNFSVSIGVSKIEQNQTDLSHLIKHADIALYEAKRQGRN
RVIHYNCMDFCS
>H6RP43|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MVDRERSRSRLLLAAFVVVVLTLALPQPGQVHWPAALLAVAAIAATWTASLVPALWPAMN
RVGGVVTAVEIAALVAATGGPRSPYSVLYGMLLLYTAVFYGTRRLLLTGVVVAAAAAAPH
AWPAAPGTEAEGTELLIRLAVWAGTCAVAHGLVTQLRRRTRQLREQEQRYRSLFDHNPNA
VYSMDTEGRFTSANAVAHRLMGAGPGELIGDSVVKLAAPDDAAETARRFAAALDGHPQNY
WTSVVDRQGRRVEVSVSNLPIMVDGRVVGVYGIAKDISELKALQDTLAHQALHDPLTGLA
NRTLLADHAELAIADSTRSGKPVALLMLDLDGFKQVNDTLGHAAGDDLLVEVAARLRRCT
RPADTLARLGGDEFALVLPNTDTSSAAGIAERILSELAPPVSVAGQQITLAASIGIVVDQ
MTGREAAELLAQADAAMYAAKRAGKGRYELFHPALRHPESLPGMRTADARAWAAYMAALR
AEITDRKQSGLPTAPRAPAVVHRTLEQLLAAIAALPPEAAVADLALPTRVDLEAFVFHQS
AVDHWANTLVQDGTLTTRCPRAADRFWAYLQAWVVSAAPCDEAVAAMADTPAP
>A0A1V5CCN5|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin002|TrEMBL
MALFDIDDFKSVNDTYGHLAGDAVLQRLAELMKGSLRTIDIVGRYGGEEFLAILPETDGA
NGYTVAERFRETVEKEYFVYGGERIMMTISGGVGRYTYGMDVNKLIKVADDNLFRAKREG
KNRIVL
>A0A1V5P8E8|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin356|TrEMBL
MLAAAAAIRSSDIIFRLGGDEFVCLFNGVNENSAKLCAEKVLNAVAALKFTVKDTQLALT
VSIGLSRFLESDSGYIDALKRADEAMYASKEKGGNTLTVG
>A0A3P8KU10|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKDYPKGPRPTFKRALRRISMISVIISMTLVWLLLSTASVFTLKQYAQKNLELTAATMS
RSLEAALVFGDSAAAEDTLATLGKQGQFSEALVLDSQKKHFALWHNRELVSEEKLSGLIS
RWLFPHPTTQPIWHEGKMIGELRLTALDRLISHFLGISIIVLTGSILLASFIALLLTHSL
HRGIVTALQSITEVVHDIRENRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVIGKLMNDDVTHRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMAFAGTHHQAWRLGGDEFAILLRNVHTEAEVQAQCALLSAQFLQPFNL
HNGHTATLSLSIGYALAWEHTSAENLQEFADQNMYRMKHQRLQQVQK
>A0A485B8E5|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSAPPSFLLLEPSALGPILRAQALGELRDATGRLGSQLLIPLATQTKIPQANREGITRGI
ERINTAWWLLQTQGDEASYIPHFQRQLENTRQAFETQGIGLINRLKEESDGNQPYSISAE
RFAIDYHASLGAFDNLLNTYMAGVKKHYTASERRALQSLLIRSLVLALVYALTIAMIFYI
RSRVLRPILRLNNIAADLIAGKQAHVQIDDDTAEEVQELFSSLGTLGKKLREDARISRQY
QRQSEEDPLTHLFNRRAFNSRGEALLRQSSEALSAWLIMLDVDRFKSINDSWGHPMGDEV
LVALAKTLNKFSRPSDVVGRLGGEEFAVLFLAPTAQDVASYAARIQHEIRKLTFHTSGGE
TFKVTASFGVSQGWQCPLEELLSRADSELYKAKNSGRDRICGLP
>A0A1V2BHP9|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKSLWGRKLRRLSSPGHVVNFCFVVVLFFSTLLIWREIMVLEEAYVDNQHNNLENVAHE
MDGLLQFNTDRMIFFRNGMQSALETPLDFMILRKAEQEYISKRHEAIWSVALHNRRTLPV
YGVSDAFVDKDPTLSRDNTLSGNELMATLELGYLLRLTNNNRGFTERMLYVSRSGFFVST
EALTDTTQALALYSAATRSPWFTRQDQRTNLGRGVVWQTFPEEGSLSDAQVVTASIPLDF
RHYWHGVLAMDFSVREIKAFLMNAAKGGQDGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
ETLSYAFSHDNKGGIRLLTRYISWEKLKNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGLFERAIAAAGECERGK
RPFAVIQLDLDYFKRVNDLHGHQSGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPN
TTLQESTAIAERIRVRINSREILLCNNASLRISASLGVSSSDDCAEVNFENLQSIADRRL
YLAKQHGRNRVCSVG
>A0A517QYN6|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan189|TrEMBL
MTVSDSHYQDGSLLLFTGLASVLVIAAVLLGTQLGWTPGAATVCMLATPVAVAAANRPHR
HALIAALIASVGVCVEAALSTAPDSGTPTWYLPLAGSVMLTGMAFFVGRARDQAVQEIVR
VRSMNATYLEDLVEIERGIRTLQGPEIAAVEQFKDGPQSGRRDDDVVNYAMLLLSLQDVG
RRVSTHVRLDTLIPTIITTTRATLRCRAASIYLYDESDRSLRNVFEPRYRDRHLYVPKVD
SGAGKWVLDNRRPLTPEEAATDTELAKQLGNERLPDGIAPLSVGGTLLGLLIVEGCERNT
PMFRKLLHIIASFAALALKNAQLFERIEESARHDPLTGILNRGAIEIALVDLVEQSRRTA
RPFGIILADIDHFKKFNDTYGHQAGDHVLIEVGRVWKEVAGPDCHVGRFGGEEFIALIPD
SDTDQTEQLAEDLRLTIGDHVIRHETDILQVTASFGVTSFNPGNQPAGPAIRDLIGRSDR
ALYRAKDRGRNCVEVARELDSSKNRTSNEQEGRK
>A0A399EG06|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MASPVDPAAFEASRRRTGLLLLPLAAMATAGAWLLSYANHSLNPVDRWFLPLLSLEALAL
TALLYFRRFSVREAEVGALGGLGLYQLLMLLYLVVSGEVYRDGFGATSLWYPLIFPLAFL
VLPREQALRLSVAYYLLGLVIGLAGMALGAAPTLKALNSFVQFYVVCVAYLVLLDIYARV
REQYFVMRHMAHTDPLTGLANRRAGRERLEHALGRAQPGRVAVLLADLDHFKEVNDRYGH
PVGDQVLREVAFRLDQELREGDVLVRWGGEEFLILAQGTDLEQAQHLAQRLGRAVQDEPV
VGTIGVSLSFGVAVFRPGDSAETLVERADRALYRAKHLGRRRVELEV
>A0A850FAT2|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium BIT-l23|TrEMBL
MLADRSQRKSFFKNPRRVVNICFTFVFICSTLLTWREMAVLEDAWISNQRNSLDNVATAL
DRQLQHSVDNLLFYRNIMSYALRYPISTDKSRQAMADFERQRTHEHWQIKLDVNRSMPLN
GVSDEFVGTSGLLLRDADYLHGELSGALEFSYILQLSDNSRDLQHRTYYVSRAGFYISSR
PPRNDEQLVSRYYRQVARPYFAQHSERYNKGRGLIWDHTWDPTRGGDQVITASVPLDYEH
RWYGVLAMDFTIDSMHQFLQRALQDGNEGVVLLYDRKFNAIATSADAMPEGKMFTPTQLA
QLARAMESKNEGEIRMAHSVVTWDKLNNFDGVLVKIHSLDEGIRGEFGRISVVLGLLWVL
FSAMLGGSWLLIHRLVKNMMNLQSTLSWRANYDTLTRLYNRGAFFDQAQYLADYCRQSGQ
SFAVIQLDLDHFKSINDRFGHDSGDRVLASAGAILSASLRGDDIAGRIGGEEFCVVLPGS
SLNQASAVAERIRERINGKEILVRSGQTLHISASFGVSCSQEHGDYDFEHLQSIADGRLY
KAKEGGRNRVCDSD
>A0A1S7U201|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense NCPPB 1641|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDESILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFANIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISAVLGENDMVSRLGGDEFAIIQSANGDCES
DAAMLAARVVHAVSRSFSLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEPGMDMAAQHKHALEIDMKSALENQEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLIAPDRFIALAEENNFIKPLGEWVLAQACRDAMTWPKDIRLAVNLSAVQLSNDDIV
PIVDRALETSGFPAERLELEVTETVMLERDNSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPSNPMCSAIVNTVIDMAEQIGLKVTAEGVENREQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAPIAKDEFGDIGRPTQETYCPPQKAI
>A0A378ZDV8|diguanylate cyclase|EC 2.7.7.65|Paenibacillus thiaminolyticus|TrEMBL
MKYTGRIIMTAMTLCGWVALIAYLMSAKMMNPMLAVLTIMMLGVSWRCGKRYDVVKYESE
IDPMTLAYNRRSADVIFQRLAGKHRKNGQKTAVFFFDVDRFKEINDTYGHNAGDRVLRLI
STVLLNTSGSETAVVRWGGDEFVFMVPCSDRCELRSIRSRIMNKLALTAEQASVPFAVSY
GYAVYPEEGTLLSDIVEMADRHMMRIKRSKLRCGSQDTAKMQLSLQ
>A0A093SD08|diguanylate cyclase|EC 2.7.7.65|Pectobacterium betavasculorum|TrEMBL
MNELLNVNKQRDNGESSYNQVITSEWTQLIATTSQQSFNLLRTLAAQKASDFANEFYTYM
LKDQEASLFLSSQQVHDRLHGSMSKWITAILTNTGDHLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYENIAQVANDKALCFDAIRFASISMDIAIEIMSKTYSQSHNQAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSDFGLWFNHKGK
SSFSNIQGIRTIATIMAETDEYIRSYSNTALLTQQDYAPLLKAVRSKIYKINVLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTPLSIAMIDIDHFKSVNDTYGHTA
GDKILKRIAEILYENTRNSDYVFRYGGEEFMIVLIETPRVAAYTIIERLRKKVQDLAIHL
QSGENVRMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A4V2LYL2|diguanylate cyclase|EC 2.7.7.65|Kosakonia quasisacchari|TrEMBL
MKKQHQRVLVTTPYPGLRLLSLGLLSFIFTLFSLELIRFGTVIAPLWFPTAIMTVAFYRH
AGKMWPGIAFACALGNVAATVLLFSVSFVDLRYTAVNIVEAAVGAVLLRKLLPWYNPLQN
LSDWIRLAIGSAVVPPLVGGALICLLVPPENVLRTFIIWVLSESIGALALVPLGLLFKPH
YLLRHRKPQLLLETLATLAVTLMLSWLSLHYLPWPFTAVIVLLMWSAVRLPRMEAFLVFL
ITVMTVSLIIAQEPNVIIAPKSGVMTNAPWLPFLMILLPVNVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTDGQWLQANKALCQFLGYSQDELRLMNFQQLTWPEDLHKDL
ELLDQLARGDIPTYSLEKRYYTRNGDLVWGLLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWELEPDIISWDKRMFEMYEVPAHMKPTWHLWYERIL
PEDRPETERIIRDALAARVAFKLEFRVPVKEGIRHIRTLANRVLNKNGEVERLLGVNMDM
TEVKQLNDALFQEKERLHITLDSIGEAVLCTDVDMKVTFMNPVAEKMSGWPQEHAIGQPL
LTVLHITFGDNGPAMENIHSGDMSRTAIEQDVVLHCRTGGSFDIHYSVTPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLVTVQEFHQRHALVFID
LDRFKAVNDTAGHAAGDALLREISSLMLSMLRSTDILARLGGDEFGLLLPDCNVESARYI
SGRMIEAINDYEFMWEGRQHRIGASAGITIIDETNYQASDVMSQADIACYASKNNGRGMV
TVYEAQQGLMQHERSMMSLDEQWHMIKDNHLLMIARGVASPRVPEACNFWLLSLRLWTSE
GEVMEEHAFRSGLTEPELIRALDRRVFHEFFRNHATAVAGKGLGVALPLSVVGLASQSLV
TELLQMLESGSMQGRLLHLIIHADALMREGNTINENLKRLRHAGCRIIFSHIGHDLEVFN
YLTPHMADYLLLEPELVTNVHGNLMDEMMVTIIQGHAQRLGVKSIAGPTHQPLMMDTLSG
IGIDLIYGDIISQAQPLDLMLNTSYFAIN
>A0A5E4VRE4|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrae|TrEMBL
MIESLKGRVALKTALVSMVLIAGVAFGIEFFVYGELRDSLQAQLDTQVRLVSDQLDDKVR
GKFLALQRMAHHVAGRLDMTPAQMQAFASASVSMPETFNTIFIASPDGRLLFDSTFPKTP
LNVADRDYFKRVMAGAPQAISGLVAGKITGAPGVVLAVPVHGPNGEVSAVIGGAVNLLRE
NFIIDLATSHVGSSGRYCLLTDETPSRYVMHSDLSMLVKPAADERNLCGADTTGSSLLVS
MRPLVARADMATTHWALVAVLPGVEAFSPLTKVRQRVALLAGVAIALTAFVMWWVARGLL
RPLDTLRDLVQRSSGDLRAVEALPVQRADEIGALANEFRQLMLQLGDHTDALESSRESAR
ANARRMQQIADRVPYLVMFLDAHERFAFVNRACELRLKRPRGRIVGETVQALLGGDMYAV
VGPHLARAYQGESATFHWEHGSGDEYHCFEASYQPEWVSGHVLAGVHVFVRDITIERSNE
RRWRRESHTDHLTGLLNRKGFDNRLTTAMRRARDGESSQALLLVDLDRFKAVNDTYGHSV
GDELLRRFAKRLATCVRSTDAIARFGGDEFAIVMTDVGDPRVAERAAVAILDAASRPMAL
SVGDIAIGACVGVTFVPAGESKTAGIVFDEADRALYGAKHSGRGIYLTSRDLEGDTV
>D6J9T8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli B354|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7Z9BEJ1|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MKPQKRMIDNHNFVPISPGLNHASGRIQPHGLLLTLEEPDLKILQVSRNTMKLCGVSPAA
FINRPLGNFLDKLQLFQIQDCLTHNKFHYYNPIRLIFHIKNKKFVCDGILHRHQGVVILE
LEPNQDKNTSFINFYHLVRGSVCKIQSATNFKDLTQFLAEEIRKISEFDRVMIYQFDQEN
NGLVIAEDKRPDLESFLGLHYPSLDIPEAARELYRQNWLRLLVDIDHQPVEIIPPLHPVS
QQPLDLSFSVLRSMSPCHLQYLKNMGVEATLCISLIKKENLWGLIACHHYSSRYLPYTTR
KACEFLGQVMAVELPYKEISEDYEYYRKILKLVRNNLIKAPALQTSFIQTLAQDKTNLLN
LVKAQGAVIRFGEDLILVGQTPPLTEVKKLMAWLSRYCHQEIFYTDCLPKLYPEAESYQD
IISGIMAISLSPNQSEYHLIWFRPEVIQTINWAGNPQEIREIAQQQEIPLTPRQSFALWK
ETVKLKSLPWKPVEIETAQELRNSLMLAALESSEHQLRQSRELAQVTLKSIGDAVITTNS
RGEIESLNPVAEELTGWSLIEAKGLPLNDVFKIFDSQTHDFSATPVQKVLEEGCIFDFSD
NVILKAKDGKERFIDNSAAPIRSREGEIIGAVLVFRDVTQERELMRRLSWQACHDALTGL
INRSEFEKLVTQTLQMLSISPNNHAICYLDLDQFKIINDTCGHLAGDELLRQLSYLLQSQ
VTERDTLARLGGDEFGLLLNHYSLEEAYQKAVDLCNSVKDFRFTWEEKVFSIGVSIGLVG
IDEQTCDLATILSAVDAACYAAKNQGRNRVHLYQADDQDLIQQRREIRWAAQIPQALEED
RFCLYYQPIVETNPTSKSPKHGEILLRLRDTSGQLVPPMAFIPAAERYDLMKSIDRWVIR
TVFNHLQKHHQDFNSTTNILGDQEFYAINLSGASLNDNQFIKFLYQQFELYQIPPAMICF
EITETLAIANIKKAVQLIQSFKGLGCSFALDDFGSGMSSFSYLKTLPIDYLKIDGCFVKE
LLTDPVAREIVESIHRIGHVMQIKTIAEFVENDAILTEIKNIGIDYVQGYGIGKPQPFIL
PMIKNSRQIDRNPD
>A0A5E4YQS6|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MKSTISRTEQGNRVAATTILVACAALTLAGFLTRAFEGAVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTQGVLLANQLAGISTHVTRAPFWLWLVAEA
SFAAYVMISVRSYSRTRSDPHTRPGYRDAARHGATVLIIWLTVSLSVVGAARTLVTPKFA
GGVDIETMALGALFVAYVALWWRIAAVTRLSHKLFLLVWVVVTISLCQLLLALTAPSEAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRIVADRVQQYNTPLSVLIIDIDLFKQVNDRYGHPFGDTVLQRIANTIQHCIRLPSDFVV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKAREDGEAITISVGIASWHP
GEPLVISAMLERADKALYQAKHKGRDQSVLGQLAA
>A0A5E4XV46|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MLLCVFAAWGLARFAADQLVANRSARLLAEERSVATRLARGTVHTVNQDLILIRGIPQVL
AQISQIQRAAADIADHPMTELPHEMAREKLLANAALKPVNELLRAAQLYFGADLVWLGTP
DGVTIASSDAKGPNPLVGDNYGDRGYFQAAVLGTAGQQYVIGRKTRLPGIYFTAPVYQDG
RLVGVMVVKLGLRRLSHWVDTGASFVTDVNGVIVLANDPTFTGLAVPGAPVFKMTPAERR
HLYQQDDFTVVPIEDYDPAPGTPPFLLPGTRGEPQAHHDPDAADLVRVRPDNQPYLLESA
SSMDSELVIYTMSEVPTLRSLFIERQRYTVLMFGLMLSSAGALVLLIRHLRRGKLQLSDT
LAKNAALEHEVKYDALTGSLSRGHFLKRLRSEVNQANATGVPACIVLVDLDHFKQINDTW
GHALGDTVLATFVRLCHDSLREDDICGRLGGEEFAIILSGATEARAFDAAERLREAVRAA
RINVDGRALQFTISAGVAQWHAGDDDNAWLQRADAALYLAKSRGRDRCARESDLRVLTGG
GS
>A0A5E4VLL3|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MTHSAPTPVHGDNTRAAHELWHGELLSPASLPSDDMRGRMGATPFAQSPSSMLPVTELLS
STRYAMPARRDMTTPGAHSPQPQPLTQDSLHSLLPTSYAANRGATVDEAARLAALRRYDI
LDSSPEPAFDRIVRIASYVLGTPISLVSLIDETRQWFKAKQGIDATQTPRSMAFCAHAIL
SDDVLVVPDAHADRRFADNPLVTGDPHIRFYAGAPLRTPEGHRLGTLCVIDRRPRTLDAE
MRGLLADLSALVVDELELRRVNQVLGDMAMRDGLTGALNRRAFLMQAEQAFANARAQRRR
LAVLMIDIDHFKAINDTWGHAIGDRVIVELTLVARATLRKGTVMGRLGGEEFAVLLPEAD
AHRAMQAADRLLSAISNTSVPGATGPVRFTASIGVGSLSPDDADFGAVLQRADRAMYAAK
QAGRNRVAIV
>A0A8F5IDZ8|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MPPQRFLSLTISATTRDQLVLAAAVFVACVLGIVSRPAGYIAVIWPANALLLGLLLRNRA
LALQPLSWLLAFGAYFAADLATGSDFTVALGMNLANLLGVAAGWLYFRRQSASTLEFKRQ
HSVLHLLAGSAVAALASALPGALASTRLFNAELWPTLQRWFAGELFDMLLILPVLLRAPQ
GWFWQWRWKLLLQRALAAQRAPLAALLVSIGLVHLLQGPGAVGYLVPALVWCAMGYGVWG
TALLTLLACTSATALLLAGGVVGFSQTLIHGATSFQVGVGLISLAPLTVSVAHELRARAL
RKLRFALNYDELTNALSRRTLMERGRRLVQRMAREGGAVAILMADLDHFKRINDSYGHAQ
GDLVLRHFTALALRNLRAQDLFGRIGGEEFVLVLPEANAEQALAVAERIRNQMREHPFGQ
RDGMPLYVTVSMGLRAAWPVRPDDTLERLLSEADAALYRAKKRGRDQVHCHPPLPAAAAS
AA
>A0A5J4E4G8|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg03|TrEMBL
MTAGKNYQRIYLTTFVFIAALITASVIIIDYIAAEEEHMVEVTDIGGRQRMLSERTVHLL
LEYAMENNQEARDQIVKLMELSLQKFDQAHQQLIRGRLSDGEVVIFSDSIDNIFFDEPEY
LDLKARIFIYNTREVLDREWSPDLISSYYLKQLREATKQDLHSSLDVLASQYTANSKSRI
TRLRVTVAILLGGIVVVLCGVGLLVFNPMFKRIEAQEQALHKLAYIDPLANCHNRRSFLA
IANTTFERSRRYKHTFAILFIDIDRFKAINDNHGHAIGDKAIKEMTQICLENIRDSDIIG
RIGGDEFGIILQECGLDYAIQTAEKLRKRISDHIVPSKSATIKFSISVGAATVKDSDTSV
DDTMKRADKNLYKAKRTGRNLVIAA
>A0A212KAW0|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MPREAMLLVDRTDASGMHLRPLWRLAVAAEDDGQGPRFVVADYRADILFDRLARLADDTP
GAILLVGGRGVWSAETGRTLPRIWEHQDLAADPPPPLRANSETWRRILGETSGVAPVRGG
FVVFRKVFPALKGFWGLNDDGTAAPERSEWRILALVSPEAVAEVENGILESLVPSTLAAL
LTLGLLSWIGALSWTGYRSRHARLVRQATTDALTGALNRAAFDEGFRAAVDRYAASGEGF
ALIYVDLDDFKGINDRFGHDAGDACLVETVRRIRAVIREGDLIGRLGGDEFAAVLAPLRG
RAAAEAIRDKIRAALAIGPPPFPGAAGPIAASLGLALCPDDGTEAEMLLRAADLGMYGAK
RRRDAPPS
>A0A0S3PP12|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MLTIDTHTISERSRKVGMTVTSWLTCGLISVMLMCVLATFLYIDRQQSDVAQVRLQTHAM
MRMQHSIAWTHLAVLELVLQHSDQTDFGAYSRALNVLNTQSSDALPKMTWRGTATVPTSE
VLETLKSHWAEIIAALNVGQPDRARAVYLTRDVSGIASNLLKTMTIDIDRYKEVIGDTQL
RIQNATTLALILQILSGIFCICAFAATARTGARDAKARDIAVCAANASREQVTQLFEMTE
MLQSATERSDANVVLRSAASELMPDFGGALYVFNNSRDRLTLSTTWNQAGEDLPDSIGLQ
QCWAMKRGKPHINRADGKKLSCEHHTGNLDVLEIPMIARGEILGLLQIFASGENAVERLQ
QQMGLGSALADAMSLALANISLRDKLRSQALRDPLTGLYNRRYMEDALERTVRMTDREKQ
EVSVIMIDLDHFKRLNDQHGHAKGDSVLRDTAAVIMSQLRDTDIACRYGGEELIVVMPNC
DLDAAAQKAESLRAAIEALSEPNGAKVSASLGVAAIPSTSHAVRDMVASADAALYRAKQD
GRNRVALASRRDEPATELPENVTRLEAAE
>A0A4S4AML9|diguanylate cyclase|EC 2.7.7.65|Azoarcus nasutitermitis|TrEMBL
MHSGESIAADWAKLFDDVSTGVRNTVYDTVLTYGADMADAFYARMLTDPDARPFLTHEAV
EKRLRFSMKHWLETLFSCSDVERFAAAMAMQRHVGEVHARVELPVNIVARGARVLKGEIA
HRLLGAGLAASDLVDAVLYVDNLIDLAFEEMSSAYVASHERAARTDEAYRVFSYGQNMSL
ERERQRSALLDWENRFLQEMMNGAPGDELQTLADSSFGLWLHHKANTIFEGSSELPIVRQ
TMHTVDDNLLPLCQQQFGNPDREEVRRLSKIVQAELGQLKFLIDGMFERFVSLESGKDAL
TQLLNRRFLPAVLSREIELSRRHRKPFAVLLADIDHFKHINDRYGHEAGDRVLQQTANLL
LNTVRSGDFVFRYGGEEFLVLLVEVDDAHTRRVAEKLRARIEQEIFLLPNGQSLRATASI
GIALHDSHPDYQRLINRADDALYRAKHEGRNRCMSADE
>A0A381IA21|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MKKREKVFDGLVFKHILILLILLVLIDLTSTIIYASNSMEITSRNMIEASKRELENYLEV
NISLLKALSQDDRFSNGETSLIEKGKLLSPYQKEYNLFMIGITDTKGNASSTYRENVNSI
KDKPSFEKAIKTKQVVVSDIEVSNVTGDKVFIIYVPIVKNNEMIGTIFASFYFQDVNNLI
SRSNFDDSIKFLMIDKDYTIISHPNKKYVNDKSKMLDLEGNIIGTTKSEILKNINKKCQG
DFLSWDNWRLYNVKYTNIKWTNWTLVSKCNIFKNFKNLIVNFMIKLYFYIVIFMILWKLS
NAKLIEQLKKLAYYDSLSGIKNKEKFRKDSMYILKNYYQDNFYLVQLDVNKFKYINEMFG
YAEGNKILIHISQVFK
>A0A2Z4UL70|diguanylate cyclase|EC 2.7.7.65|Rhodobiaceae bacterium|TrEMBL
MKIGEKRPVGKATIRGAAAPAANTTPSDVVGVDGRVIKDSTSIMGIPEPELTPSVRTAIM
TLMGEVDKMRKEMRSVRERLRSAEALADHDALLPLLNRRAFVRELSTAISYAKRYQTPLS
LLYIDIDGFKAINDTYGHAAGDAVLNDVARKIIAHIRESDIAGRLGGDEFGIILPHAAEK
SARAKASSISDVVARDPVLMEGQSLAVTISIGAVMIGPDDEPEGALARADKAMYTAKRFS
RSSH
>A0A2S6G8N7|diguanylate cyclase|EC 2.7.7.65|Marinobacter persicus|TrEMBL
MPRFSSEHLCSEWLAINARFTADAQRFVADFARQHAASLSEHFYQEMLADPGASQFLSND
EVQNRLGQSMQRWVAGLFAPTTEEDVFRLIAEQRKIGEVHARIGIPVHLVLRGARCLKGR
FVHLLHHTSELDENTHFAATRLASDTIDLAMEIMGHAYSVSHDRNSRAEEAYRLFAITQN
IANEKDQQRAALFDWENQLMFSQAIGTLPGELPRIQASDFGLWFRHKGIHAFEGSDEARA
VMDTMEEIDNVLLPLFGADEQSTVLGTTHVDLLKDLRDKVKSIRFHLGNLFEQNNELEAG
RDVLTRLLNRKFMPVVLGKQISQARAQKTSFAVLAIDIDYFKQVNDNHGHQAGDQVLQQL
ALILVNNSRSGDYLFRLGGEEFLLIAVDMDATRAKAMAEKLRKSVEREAFLLPDGKELQT
SISVGVACFEGHPDYQLLLRRADDALYSAKNRGRNRVVMATATDTAPQANPPG
>A0A1S7S6G0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. NCPPB 925|TrEMBL
MFTVLECVAIQHDHAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAAGLS
VWATHFVAMLAYKGAVPIGYDFFFTALSALLAVLGFWLALKTRSQVIYKPVIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWVAFVLAFFLFHRPGSWKRIAAPAGAAI
FGICALHFTTMSATVLTPDPSVSGPDPDNVARLIMICAISGVTFLILSSTAVAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGRDEATLVGQNPDDLFKAIDGQPTYLP
RPAPVEAIRERGGQAQVFELGVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIDNCGEEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTTRHTKADEARLLAETILGMFGLKMNVASDPTAVGVSIGIA
VFPRDGQDHESIMHAADLALYRAKMGGRGILAFYDPLMDQEARERRQLETDLRLAINRDE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQASTWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKAT
LVILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSEDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAPAESTAKRKKHSV
>A0A7Y8Q585|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SwsAc6|TrEMBL
MPQNVSIQLSETWKSICDQYSALDHHLTVELTTKNLDAFVAAFYKQMLLEPESAEYFSDN
IIQKRLIDTLKAWLLETFNVALNGQYESAVLRQQKVGNVHARVGIPSWLIMRGVREIERT
MFEYIASDNSTNYMNVVSYVVQLLGFSTEIMCRTYEDKTAKNHEVKHSYRLFSAMQDVAV
HKDRQRGSLLDWENDLMFKIFSGQGKFYQQLFSKSEFGLWFIHKASYAFTGSEQVGLITK
RIYEIDALTEECMLLEGREQLMLMVQKIRSINREIQHLVDQLFQVTEYIESGNDALTQLL
NRRYLNTIVGREISYARKHRSALSLLALDADYFKTVNDRYGHAAGDMALKFIAETLQKFS
KGSDYAFRIGGEEFLLLLVDSDLSRAKMVAENVRMCIEDTTLQTSVGEDFNFTVSIGCTQ
YDGHPDYQRFLDATDLALYSAKNRGRNCVYVTEVQKMA
>A0A3N6FQL8|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI95-17|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVNGLGYELACVNLVRPDGD
LVVAAFAGNSAAEALITGRVGSRTSWERRLSMGQAWDELRFIPHTDGWVLLDDDVPQWHT
DGPDPRFEDEWHPQDRLYAPMYASGGGADLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
TNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELHLAHRASHDALTGLPNSAELRSRLSARLCER
PNAAVTTPVEALDAAYGDVDDPDARTHGYEVDPAPGGPYDHHVHSVAPDTEHDDGAKGLA
VLFCDLDGFKSINDRFGHHTGDAVLIEVARRLTTCVRDGDTVARLGGDEFVVLADGLGDA
DAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAACGMTAEEVLRSADQRMYVEKRSRS
KVHRRAG
>A0A655DF21|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MVGIAIQHVIQKRYDNFAQQLMFKLLAERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAP
GSHEHYVLLLDIDHFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLL
TTAEPQQARATAERIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIGDAIEKADKA
LYEAKHLGRNHILVSDDMRAL
>A0A173TA57|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MSETYFEYADETVTAAEQYSEKIAARIRLTEIISALDILLLIFLIVQQQIQHIKAVRENH
ILSKKAYLDVHTGLPNKSRCEDLLNSSGFITEPLCFVMFDLNNLKEVNDTLGHAAGDSMI
ANFAHILRKVVPEKDFVGRYGGDEFIAILYDTTSGQADELLEKLHATIKQYHSSNMPDAI
SYAYGYSYSMNYKDCTLRNLLDKADHEMYLNKQAQKKKR
>A0A6C0YRN8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFVFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSPLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A7C8HXN5|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MLRIFHNLFGINEQSRFQRAWQAFLLGICAPFGWLFITFLLQLTPVDPLYEVALYTYITV
GSVFAMVGFALCISKSEEHFARMSLLDPLTTLYNSRYLLTRADQEFALLERTGQHMALLM
ADIDHFKYVNDQYGHSVGDIVLHQVAKVMQTTARKVDVVARVGGEEFALLLPNSTTAGAM
ILAERIREQIEHTPIVLPDGRSFNVKISLGASSTEEFLPQVFNELYESADNALYRAKRDG
RNRVVKAVETDMLTNDVAC
>A0A518LBW1|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium TBK1r|TrEMBL
MSLQSPQPSAKYSDTQTFEAGTLRVEEGVTSSDRQTPKRAFLNVIRSRADIGVNAFLEDR
TVIGRNPTCTFPLHDLKVSGHHAAITPSGDGEFVLEDLNSTNGTRVDSTPLIGRRTLRDG
DKIFVGETVIRFSLADELDIDFHSEVATLVGRDPLTDLPSKRRFDEALEFSLQSSQRRDV
PLAVLMMDMDGVKQINDTYGHLYGAHVIGETGRLIANVLGSRGQACRFGGDEFSAFLPGH
DLEAALGIGEQIRVAVASAGFEKNGVALRPTISIGVACFQTTATDTLSLVTAADAALYRA
KARGKNCVTA
>A0A5U3DS81|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAVADTLATLGRQGQFAAAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSHPIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
NGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFAQDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQEFNRPFELH
NGKQVKMTLSIGFALAWEHTSAEKLQELADRNMYQAKHRRTRHLLK
>A0A8G0UGL8|diguanylate cyclase|EC 2.7.7.65|Diaphorobacter sp. MNS-0|TrEMBL
MTPPEHVAAWEDVAPEREPEGFAWLPGPLVGKLLAVAALAIVLSAMLTVWVLSRAAGQEV
MQRLVSQQNDEVELVARLLASKIEQSQKVLATVAEGITPELLESPASLEWLLQQGLPAVR
FFDAIQVARKDGNLAINLRYGKLEKASGLDPGERDYLVRTLLDGKPLVSGLIGATPAEAR
VMFTMPLLRGEGRVIGAVAGVLRLQSQGLLPHSLALPARSDSQLVVFTRDGVILAHPNME
RVLGQVADEPGLGEAYARWRRADDAPLAGRAQTTVQADHVVSLASVPMPQWVVARVSASQ
AVLAPMQGVQRRAWALAAAATALVALLALGAMLWIARPLILLRQRARALMDAEAAGAPAS
GSAGHDGPWPHSPGEVDDVVRVCTRLLEHRRLQQRGSEASARQLRAVLAHVPLGIVVSRD
EQVEVVSQQAGRMLGYAPAQLQGRRLTDLLASPPGAVDVAQQVRARFAAHGSFDGELPLL
RKDGSTLWVRAQGQLVEPGVPASGLVWTLEDFTAERAARQQQSWERAHDPLTQLLNRTEF
ELRLQMLLDARAARGPRGVPEEDGGVLLFMDLDHFTVVNDVAGHDAGDDVLRHLARLLES
EVRHNGWAARVGGDEFAIVLPGSSLARGQAVAEQLRAAVQAWEPAYGGRSFTLGLSVGLV
PLAPGAHGVAALLYAADMACYQAKRAGRNRIAVGSVQVPA
>A0A6C8MM97|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A443W468|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALFSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A7H4N8Q1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MSGCVKKISQLAFSVGADNEISITASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCV
KLHEGDGN
>A0A7H4N8Q3|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVRDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKTSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVCPKA
>A0A7H4MT32|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSASPTTSIIPLAN
>A0A447R8N2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLLRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379TN26|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MLISLLSVLFIGSIAFSANIVAFTLYALPSVALCLWLNGNEQGLRILYLMALPMVGIAIQ
HIIQKRYDNFAQQLMFKLLAERETLNSLSMLDPLTGLYNRRGLQSRLDTLQALDSHEHYV
LLLDIDHFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTATEPQQ
ARATAERIRQKVYDLKIPHMFNESVATNVTVSIGIAPLADRNIGDAIEKADKALYEAKHL
GRNHILVSGDLHAM
>A0A7H4LUS8|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MQKLTEQGVNIVFMALDCDRLKYLNDTWGHDEGDRAIVLLAQSISAAIRKSDYGIRLGGD
EFFLILIDYEEQEAKNIPERIRQHLKEIDINQRVNFSWGACSMAPGDSLADVMKIADARL
YENKKQKKHAYPGRED
>A0A4S4ATU3|diguanylate cyclase|EC 2.7.7.65|Azoarcus rhizosphaerae|TrEMBL
MPAAAPPHSTAIEAHWLSLFDGVSAATRTALRDVVLAHREAMATAFYAHMLADPDAQPFL
THEAVEQRLHHSLQRWLETLFSCTDREQFGAAMAMQRHVGDVHARVDLPVNIVARGARVL
KGQIAHRLLDAGLDGETLVDAVLYADNLIDLAFEEMSSAYVASHERAARIDEAYRVFSYG
QNMSLERERQRAALLDWENRFLHEMMAGAPGDELQTLADSSFGLWLQHKASAIFEGSTEL
PTIHAVIRTVDGSLIPLCQTQLDAPEREEIRRLTKAVQTELGQLKFLADAMFERFVDLES
GKDALTQLLNRRFLPAILSREADISRSQGKPFALLLVDVDHFKHINDRHGHDAGDRVLQQ
IASLLLNTVRSGDFVFRYGGEEFLVLLVEVDELHALRVAEKIRNRVAQESFLLSDGHTLR
VTASIGLALHDGHPDYQRLVNRADDALYRAKHDGRNRCVVAHG
>A0A379SZX5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MCGTSANSAITALSRVHERLNTLRLPGAPQVMLRISVGVVPLTPQIGHYRGWLKSADMAL
YKAKNTGRNRTEVAA
>A0A3S4GKR8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWVTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWDRLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8B4TNB2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MLFRRGIGRFGACMLFKELAVFDVLSTPIWVVHPFNESVVYANQASRTLSGEMSLNEMRN
GIYSTCPETQLQHYLRYLDTMTEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAV
KLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYS
DEEMRNKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGTLRHVQTYAGPVVLY
NIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFYRLVEAPSFIAQGFCLLLID
IDHFKSINDIHGHQKGDEVLLVISRILETSGDREDKIYRWGGEEFLLFLPHSPIARALIL
AEGIRQAVSEYQTLSVTVSIGVAEHHDGEAIDQLFSRVDKALYVAKNGGRNRVSRLPFEN
VELLHSRGGAA
>A0A5Y3V1N2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGHQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTKRSLN
>A0A702KYZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAEETLATLGRQGQFSAAEVSDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRAERSLN
>A0A6S6WKM5|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MSVPNTERREEPRKRLTTRLLWHVISVSVVLLLATISLVFWNTYPSAKQSVVQQLQEQVG
EKLRSNQAQLQAVEAQAELLSQAYLDRYQAFVGNPEIIGRFEKWFEETSPGVFRLQERFF
SGTQIDDRLFRGLSVFVGPGPRPLSDEYKARLVISVIVLSEMAPAWRKQVTNTHFSFPEN
SLAEYSLDDPWGRQAAKDLVITDYSTVRSTLQHENPSRTPIWTGLYHDHSSGYWTITYQQ
PLDLHGQHLINTSFDVGLQQLNETLNQTEGENVETYVLNETGALVSSSTLIKKRPERQDT
LTPETYDDPLYQEIAARLLQGDTVQGQQIWDDLDDDYLILVQHLGTPNWWYFSVYPKAMI
TSQALSLPLLIALIGVALVVAVLLTMTYFVRREVSRPLTQLAHVAALVDQKNYHEIEQQS
VERMRGYGEVKQVLSAFRTMARRFVAANEQLEKRIDERTHDLRLANRKLDELAHLDGLTE
LLNRRSLQLDIDNVLANPDVSCFFVMADLDDFKGFNDNYGHEAGDRALIAIGQLFKSVEQ
SRTYRFGGEELAMLCRAETAAEVEERLQQLQQRIHKLAIDHTHSRRASKVLTASFGYTKI
RPGETSRELIQRADKLLYKAKAQGGDCIIN
>A0A562I0N3|diguanylate cyclase|EC 2.7.7.65|Azomonas agilis|TrEMBL
MHQIPIKQLMSEWQTLTQRFPIETASALQNLAVQHAPELADLFYREMLADPISASFLTHD
QVKNHLHTSMQHWITTVLSTAALGDIQTITEQQKRIGRVHARIEIPVSLVMRGARLLKGR
LIELIEQDAQLSLPTRNNCIRLSSELIDLALEVMCFAFSQSHDRNSRAEEAYRLFSVSQN
LSDEKERQRAALLDWENHLMFELALGSDPKNLPPLATSEFGLWFRHKASHAFQGAPENQT
ILDYIAHIDQNLAQLTQDQPDKTRDLLRQLREQARSIKYLLDSLLDQARELEAGRDVLTR
LLNRKFLPVVLGKEVLYSRQSGNSFGLLMIDVDHFKSINDTYGHDAGDLVLQHIAGILSS
NIRGGDYTFRLGGEEFLVILVDITPEKAMQVAEKLRNIIANEAFHLPPDKEIALTVSLGV
AVYNGHPDYQTLLQRADKALYQAKNSGRNCCILSP
>A0A162L430|diguanylate cyclase|EC 2.7.7.65|Clostridium coskatii|TrEMBL
MYKYKNYIFEVIILLIVIAALYMTNLYSYLLFHSLAELFSVIIGFTLFIVAWNSKNFSKK
YFDYLVFIGIAYVFVAFLDLLHTLSYHGMNIFRGYNFYANQLWIGARYLESISLFIPFIF
IHFKRKLRPYLTFGIYTVVTSSIIASIFYFKVFPICFIQGKGQTLFKIISEYIICGILTT
DIILLRKNKNKFDNKVYGYLFGSIIFTIISEFEFTLYINNYAFSNLLGHYFKIISFYLIY
KAVIITCITQPYNTIFKELTDKENELEKTAATDEMTKLYNRRAGMEFLDKEMKNALRNKN
NLTICFIDVDNLKKTNDTYGHIEGDNLILNVVKLLVSNVRNSDYVCRIGGDEFLIIFPNI
AIKDAELIINRIRSDMDKLNAGSSFNYKVDFSYGFAEYNNIKKVDIDTLIEIADNNMYKN
KVQKRK
>A0A127MP18|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MEMESSTCAGIAFARRIYAPRSLGCGLSFVFIAVLTYPGHPALWAWMLVNGFLWPGLARF
IAVRAAEPYRAELRNLLLDSLFAGGWVALMHFSLLPSALLLSMVTMHNVAANGPGFMLKG
LLANAAGILAMGLLTGYQVDLETPGRVIWACLPMLFFYPLAVGWTSYSLARRLHAQRRAF
SLVDCFDQQLLLSYDVWLHRLAQEFGRCRRGGPRATLALIRIDDHARLRLRYGNLTAEAL
SVRLGHLIKAEVRNTDHVSRKHPDEYLVLFRQTHGAGARACVERIAQLFGNFDEASLPPL
SLSMGLADYSTDFASEHDWIEHARQALAPCAAAEDAAP
>A0A011NM09|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MATPSNPSEIAREALRLLAVRRLQPSPDNYRALYHEIAGTQPADALPQRELRSLAASLPQ
ETPAQQRLARRLEQVFTAGNWQQLGAGLSDVVRQIGKEQELPWNELFRDLLREWENKQAG
LTVARKREALERVLAGGSGSGEKLFGRLQGLVKSWSAAEPAGEDIPLLAPDAAAASAGGP
QSADGSAATAAVDGSDPAVQLRDLLAHLLEALTDSQLANEPDLAADARALIHKVRTASSR
SALDDLLASSKRFAFRLELLAEDRDELRASLLKLLQLLIENVGELVVEDHWLRGQIDIVR
DIVAGPLNVRSIEDAEIRLKEVIFKQSQLKHSLNEARESLKQMLAGFVDHLAEFADSTSD
YHDKIEVCAARISQAEDIAQLEQVLAEVIRETRIIQLNAQRSRDDLRAARQRVGETERRI
AELQQELERASTLVRHDQLTGALNRRGLEEAFEKEVGRAQRRQSALCVALLDIDNFKRLN
DSLGHDAGDAALIHLATVIRETMRPQDTVARFGGEEFIILLPETPVDDAQTAVVRLQREL
TRRIFLHNNDRQLITFSAGVTDVRPGDTQASVTKRADEAMYAAKQAGKNRVLIG
>A0A378Z039|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MATNQAPTLDSLQSLLATVQRNERSLKRFQDIELALMGAPDFGQFLEVVLNRLRHDFDLL
GVRLMLAEVDDTLRDLIDTAEGIRALEAGLCIAQDPGTFLAVCGDGQLWIGAPRERHAAL
FGPRPPASAVVMPLTRNGRCIGVIALGSRDAGRFAPDMATDFLERFGAVVAVCLENMWNR
ERLKRIGLTDPLTGLSNRRYFDQRLREEVVRGARYGAPLACLLIDIDHFKRVNDSHGHAT
GDRALRAASVCMRAQLRVTDTLARYGGEEFAALLVQTEQNWAGTVAERVRRAVKRLEVPG
DDGTLVPLTISIGLASVDPRDTADPETLPVRLLGAADAALYAAKRAGRDRVVVASAASLH
>A0A2N7RUF4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MWTKPVLRMNLRRLIVLVAFASALVSLANTFYASYRVQRQLLIDTTLEANHAYASKLAST
AEDFLQSARQQLAYSAGSLPSRMDDDAWLTDEAQRLRLQTNSFNSVLIVDAQGKVLGVSP
ETLALKHRHLDSAGAAQALRERRPLVTQPYISSAGNLVVFISHPIVGKDGRYLGYVGGSI
YLKQKNILYTMLGQHYYRDGSYLYVVDQKRRLLYHPDPARLGNLAGSNEVIDAIIARQGG
GNRRMDNSLGVDMLAGYAVMPSTGWGIVAQRPTAMTLAPLNQLMANTVWQSLPIALLSLP
FIWWLANLISRPLVQLAEGARRMDAPGTAEHIAAIRSWYVEAAQIKKALLKGLALLQNKI
GKLKTDVQTDPLTGLSNRRGMAAALDAWQAHARPFSVIAIDIDHFKQVNDQWGHAVGDDV
ILRLAQLMRACSRDADVLCRNGGDEFIMLLPDADLDVALQVAERLRAKVAAAVIPGAGAV
TVSLGVVSSEQDAGKAGGAEAVLLAADAALYVAKENGRNCVGITEPA
>A0A5P2MED0|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MSKQSQHVLVTLPHPLLRMASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIGASLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPVLGGLLLWLLLPKETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETVITLLVTLTLSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSMMLAADPSLLYIPKPNLTTSLPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRSLTFQQLTWPEDLNNDL
EQLDMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRNSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAKNVIRDSLAARAPFKLEFRIAVKDGVRHIRSLANRVLNKDGEVERFLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDEKNHVASDVMSQADIACYAAKNSGRGRV
CVYEPQQSEAHAARSQLSLDEQRHTITHNPMLIIARGVASPRIPETFSFWLLSLRLGTTE
GEIIEEHAFRAGLVDSTLNQALDRRVFTEFFQSAAPAVASKGLSIALPLSAAGLLNTELV
DELLGQLQRSPLPPRLLHLTVPSNVIKTNPTQAISTLHRLRQCGCRIILSHVGRDLDLFD
NLKYHMVDYLLLDSELSASVHGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A2N7RBW1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MRAALSEAEVQPDLFTVEAAALAAARRMHADAGAPGEEQRRVLGELIIHYERLMRETRRL
IGRSDRAERDMHVLNRQLQTLAGQLEYRATHDPLTGALNRGAVIDHASRCLEQGDMALIV
LDIDLFKQVNDDFGHPAGDGVIQAVVDCLKGLLGQETAIGRVGGEEFSVVWPTRSRDDAA
HVAQRICDTVGRQRHAAPITRAITVSVGLSWNRAGTAFETAYSHADQALYQAKREGRNCV
RQWLES
>A0A8F8A151|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MSAQNENIYSTANVSFQNSTTDKSLKLSECDLQNRQLIEQALTDPHARIPALFQQYFHDY
VYTHSHHNLRQINYLAQIAFLLYFFADILIIPDMFFISGLMRVVLVLGAMFCCYYLFKKY
KNIQILDRILPIGTTVAAAAWISLLALSTSPHVATYIYASAIFILIANLCVQTQFKVAVY
CSILIALFIMLGVTQFMSASQAFIFSVVFSPLWFFSIYINWNNILNVRRSFLRSLLDEWN
YQTLKNLAHTDDLTQLYNRRHFVDMAERSIHQWPKHASSCLLMFDVDHFKNINDSYGHDV
GDRVLQLIAEVTRKEMRHSDVLARFGGEEFIALLEDTQLQDSLVIAERIRCAIQKQYIYV
ESNHAIRFTISIGVAELESHTQTLEDLIKQADIALYQAKKSGRNRIEVYHPDMLNKPKPA
TENPWNVFKPDTQPAQSTAN
>Q183J0|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MRYKKRNIDKSSELSFQSLAKYFITFYIVIILIILSMFCINTIWVMKKDNQDLLSTTSNR
IEDRVGETIKLLNSLSKDNYIIDNSVNGIDKSKELSMYSDEFGYMMICFVDKNIIVWDEE
GGNISLAGRDYMQKLFATKKYQVTDSFAAGADGKTLNYTIASPIIKNGNVDGCVFAAIYF
DEIKDILKQGKGQQQQNFILFGSENQIMNLTSDETAYGEKYMKLSQKTKYLGTNAKKVEK
DMFNNKSGDYWAFENGKLYFMSYKPIKNTNWSLFCKVNFLDIFALNLIPMGAILSVITLV
FIILICMEKSFMKKRMEVIDMLLGSVQELEKRIYQTERPSEVDFKEIIQLTSKGLTDGLT
GVVTRTVFFDQIYNRVEMEENDKLSVISFVDLDDLKCINDLYGHEIGDMVLKNVGYVLRE
YEIKYNGLIGRYGGDEFVMLLSGFTSREEVEDLLDEIAIRLHTEVLTDDGIIQTHCSVGA
VVCSVKDNKDIDNLLKQADEALYYVKRNGKGNYHLV
>A0A5K1IFJ9|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSVITYLQRLANGVSTAELDVAALPTELRAIGEQLQKTHAILQQERQLLEC
NAYIDPLTNLGNRGGLDRHVEQLWRTGDPFTCAYIDIDHLKHCNDKFGHAEGNRYILSIC
RALTETMEHDEMLFRIGGDEFVLVSPTTGEAELEQRLERVRADLIEATSDDKAPMISSFS
FGCSRVDPLAGDTRRQMTLDADRKMYRYKLMHRVQQPKDNDALQHPIAEQFPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSVDMWLARVHPEDRDNVRSEL
DMVVNGTWHFHYMQYRVMDATGAYALCDCTGYRLDGTDTEPNMYVGIIINRSLADTTDSV
TGLGDIHALINAIGEMRRVPRKAGFIAIKVDDIAEVNARFGFDAGDRVLAESAACLMDCS
RGKGRLFRSTGPTFVALFDELGPEAIDELASEIERFLGSPVLIDSLEYQPPIRVATLHLD
GVDRQPVSILNELKARLKEAPQVPGTKLD
>A0A517W3D1|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MNSPLIANSNTVQQQNSVHGSYNMDSSQILKQLLALSEEYEEFSLEGNESDDVDQVISRK
HLRKLLTALQARDAATLCHSRRVAFLAKGIATNLGWEGIHLKRLEIAALVHDIGKIGVPD
HILFKPGKLTSDEIELMSHYHNIGLDVLQACRTDHEVLTILSQTRYHFSGATNGYQYIGS
DVHQGARILAIADAYDSLATDQVYRSGKKHNEIMSILMESAGTQFDGNIVCALSRWEQNE
KEVFHDALLEVNRLYQPKPFSEKEAQEANLISNIFSYLFQIESLYDGVYIVNSDLQFVIF
SPGLEKLADIHATDVLGETWTSNSLPLTNKEGTSLTTAECSMNRVIANGKPMTTEYMLER
PGGRLINIEVQSVPMFNDEGHLVGVAEIYRDLSRGLKRPQEFSDLKLAASMDALTSVANR
GELETQLAIMLARINKEQNSPPLSIMFIDADHFKNINDTYGHSIGDDVLIELARLFQHET
YSGELVGRYGGEEFVILCPETDLEHAVKKAERLRLAISNLKIENIIKTRLSASFGVAQAE
SGDTVESLFRRADKALYNAKETGRNRVCSLTSHQLLTGEEPAQVTSESTSDEMLFENTFN
AFISSDIVVYKLGGFVNDNDAKLTEVNTSHAILRLGQTGLLPFWGKTDDRRPVEVEVEFG
NFVKKTDGNKRSSTSQVEIKVRISPLGWVKQTTQFQQRANRVFRLLKNYFAAD
>A0A1V5JTJ7|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin510|TrEMBL
MELKLDAYAYRRIFDSLHDGLYIVNNQREILFWNKAAERISGFSAEEVVGRSCADNLLTH
VDGCGQNLCKGLCPLAQTICDGQSREAKVYLHHKAGHRLPVAIRVSTLYDVSGQVVGAVE
LFNDISRQKAIEARLEELEQMVMLDSLTRLANRRFIDSFVTARLEQLKRMGASFGLLFID
IDHFKNFNDRWGHSTGDAVLKFVAETLVHNARPFDLIGRWGGEEFVGVVVNVAAAQLEQL
GNRLRELVKSAYLMSPEHERLSVTVSIGATIARADDSLESLVERADRLLYASKAAGRDRL
SLG
>A0A5W0X0K1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium var. 5-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A380T7A7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MIGFGKGRERPTLRAVLGRRHLSVALLAVGLAGVSLTLLGVLALRVYANHNLHLIARSIN
YTVEAAVVFNDAGAANEALALIAAAEEVADAKVFDDNGELLARWQRSESGLLAQAEQLIV
RSLLEEPIILPVLHQGQQVGRIELVGQGGSLVRFLLSGLAGILLCTALSAFSALYLSRRM
FGDIVGPLRSLANVAHAARRERSFDRRVPPAQIAELNELGNDFNALLDELESWQSHLQSE
NESLAHQASHDSLTGLPNRAFFEGRLSRTLRNAEKHQEHLALLFLDSDNFKEVNDSFGHA
AGDEVLISVATRVRAQLRENDLVARLGGDEFAVLLAPLHKRDDALRIAEKIAASMKLPIR
LGEGQIIVTSLSIGIAYFPDDGLTPSDLLNAADAAMYQAKRNLRGQGQMAETERSAQHVK
NRS
>A0A1C5YS41|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKNNRLFKTNAVISLILLIGFALTAALSYHANYRTSLDSMEQISTLTADGICYQLTAMFT
KPVNVSLTMSHDSLLREHLSKETEYLEDEKYVDTTRNYLDTYREKYGFDSVFLVSAATSR
YYNFNGIDRVLTEDSPENAWYYDLLKSDAEYSMNVDNDEVEGADNVLTVFVNCKVKAGDG
SILGIVGVGIRIDYLEELLRTYEDKFNVTAGLLGEDGTIEISTAHNGHVKTDWFELNGRH
NIRGQILDWREKNTNLEIWADKEESGKERSYIVARYIPELNWHLVVEQNTGQLLHGIRIQ
IILTGILLIIIVVSVLLIITAVIRNFNKQITELMEERQESFVRATEQLYDNIYELNITKN
CSVGKRTREYFKSLGANDLPYSEGLRVIADKQIKEEFREGYVSTFDPPNVIREYERGNHH
LRYDFQMSEDADKYFWMRIDAYVFYSAEDDSIHMFTYRKNIEEEKKIQIQAVLDEMTRFY
SKRETERLIETVLSGTPGGRYAFFIFDIDNFKQANDCYGHRFGDFCIKEFSSIIRKHFRE
KDILGRIGGDEFAAFIPVPDIGWARKKAGELAEALNTVIENQDRSWQMSVSIGVAVYPEA
GTLFEELYGNADKALYETKIRGRNGFTIFQPYDEKGQETELENE
>A0A1C5KXQ6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEYFEESFFVDVREKMFRPLVITGGIANLCGFICNIFLYGMTGPSVVCGLCFLTIVLIGI
TGCTGGRADLAGAGIVLIISWFEFPFLYYVYGSTILPYFVMAMVAVAVFLPRRHLWFYFA
ATLLIDSTVVLVCRERVYGIVTRGADSLALAILCSLVIASFSVFCVLKALIERYESQKTD
ILEMGKKLEQAANHDGLTGLYNRRYLVRYLTELIRHTEKEFLISLIDIDDFKHLNDTYGH
AYGDQVLTELAGFMQEEIEGKGIASRFGGEEFLLVFEDGDVSGAFESLCRIQERLKAFGQ
ESKGQEITFSGGVESHREEMPLDKLFTAVDEKLYQAKNSGKRQIIG
>A0A1C5KMQ6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKERKVEKVISGILVGILIILTIFMIADVKKLQGNARVVNYAGIIRGATQRMVKLEVVDE
GNDELIQYLDDIFSGLMHGGGKYNLTHLEDTDYNAKLNRLYSYWAKLKEEVTKVREEGYK
DTDIINMSEEYFQLADKMVDAAENCSQRYATQINQIEKALIVIMILIVALLIKESVEQVV
LSKKNRELRKKAYLDLHTGLPNKSRCEELLLANDNLTELTTVAIFDLNGLKEVNDTIGHL
AGDTLIMNFANILRTSIPQQHFVGRYGGDEFIAILTGVGEEEAKKILLDVRKETGHYNSY
SKQLHLEYAYGYAVSDAYSEYCSMKILLEQADRNMYKCKAEMKEHHKNSHGEV
>A0A402ZSD6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIASQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A1J4NDC0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. LCT-H3|TrEMBL
MDNECMDMLAGQWQHICQNYSLDDLVHTFQFIQDNALILVEEFYKNMLLEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKQYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDKTKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGIQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A3R0JSV7|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPTTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2X2I8Y9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLAN
EAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSL
QSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKE
RLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLM
ENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKML
RQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAA
GDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIW
EGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQAAAHSERA
AMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQTFRRSYSD
PALSHALDPGYSTNFSSRPQKRLPVKA
>A0A3P6LM93|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTI
FKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKASQAFYDNVRSSDYVFR
YGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYE
RLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H8ZKM9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQAGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A0S4HZD9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MKSPSQTNAIDFDSAKLQRLGFGQQPPLLERPVSLALLRQQLGQQLQTSLEPQRILGLFF
REVQRLVPLDALNYRHQASDLRLEFGQRGHHSVSYSLSHEGEQLGELVFRRNQRFSELDQ
GNLESLLSALLFPMRNALLYRAATQSALRDPLTDTGNRIAMDQTLEREIEMSRRHLMPLS
LLMLDIDHFKNVNDSYGHNAGDDVLKAVATAIKNQLRNVDMVFRFGGEEFLILLSNTTRE
AAAMVGERLRAAAQAQDYRADGNAVELTVSLGCSTLLPGESAESLLRRADSALYVAKREG
RNRLTMAG
>A0A0S4HNL3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MAKAGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLDPAPWVWGLMLFNGVLWPHVAYQW
ARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSVATLSMMAMNNVAIGGMRFLLVGT
VAQILGMGVGWLAFTPAFIPLTTPLQMFACMPLLILYPLALGWICFRQATTLGQQKRELL
ALSRTDSLTGLLNHGAWKDQLEVEFQRCQRLQQGGAIALIDIDHFKAINDTYGHVAGDIV
LRQLSKMLKQNLRAADVAGRYGGDEFCVILPDMPLNSAAATMEALRDRFATLGYEQSPAL
KVSLSIGLASFSTAHTDATLWLNDADQALYEAKTTGRNRVICRTNGKPFRELLDPV
>A0A838LZ68|diguanylate cyclase|EC 2.7.7.65|Rhodocyclaceae bacterium|TrEMBL
MKNQSNNTVSLLQNALSILRELDLALSKHLHWLKELHRTLICAEAPKPGDLAVDAYRQCC
FGKWFYSLPEYLRNSEYSLHGMESPHQDMHDAARKLLLAHQQGQAISSVDYEHFMEVAMD
FKMALVSCQNHIISQICTVDHLTGAWNRHAMSMRLGEELERSRRSGAPCCLSLMDLDHFK
QVNDTHGHGAGDDVLRAVSRFIKDKIRPYDSFFRYGGEEFMICLPDTGPENAMAILNRLR
EDLADFAIPISEGQSLQITASFGITVMDVDEDLEGNFRRADHALLCAKAKGRNQVCYWEL
IPA
>A0A8F8GMJ2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter septicus|TrEMBL
MQTLDSSIFDLAPIPMWLEDYSDIKIQFDAWRAQGVEDLHAFLSEDLDRVRQCAHKIKII
SVNQQTLDLFEANSQEHLCSNLDRIFQEDMFKSHIYELIDLWNGKTHFSSVAVNYTLSGK
RLDIQLRGSILPGYEQSFERLLITTEDVTSYQNARRLEEKNRRLAEARFVYSPASLWVED
FSRVKVRIDQLKQIGIDDFRTFLDVHPEFVNQCIEDILILDVNQATLDLFQAPDKQILLK
NIHKVFSNEMLGTFREQLIELWKGNIHHQREAVNYALDGSIRNVLLQFTVFPGYEKDWGL
VQVALTDITARKKAENYLEYLGKHDVLTKLYNRSFFTEELNRLERSILRPVSCIFLDMNG
LKEVNDQLGHDVGDGLLRRVGSVLTQAIQNTTYTASRIGGDEFVILMPGTDETAVLVMLQ
TIQELFNIDNQYYSSQPISMSFGSATTLENESIEAMLKRADQQMYQRKKHFYQDKEAS
>A0A1V5IQK7|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MRPIFSSLLDVDEFKDVNDRFGHGAGDDLLTAIGEAMVASVRASDVVARLGGDEFAVLMP
GTGRFAAVTVARRVRERLGGVVTADGRKVSFSIGVVSYTIPPACADVMIRDADAVMYRAK
GLGKDRIESVMIGAQAPASTGA
>A0A0B7DDJ1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTHNAIQRLLLKRFALAAATYGLALLLLWLAFFTGHYDQSLRTIAVGSALVVISQAILFG
LFWSGCNQRFDDPSMTETQVLLGLGWQTWLIAHLDEARGAFLVFYVLILLFGLFHLSRRA
FIRCALLVFFSFCAITLWDAYHLRLPEPALAALQVCILAMVLAWLVLYARFVQVSRQRMR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLASRELNAMDNDAVHGLALI
DLDHFKRINDFYGHAAGDQVLQAFAGVAQACLRDGDVLARYGGEEFVVLLPDCDAERLTA
CCERLRIAFTDVELVGLNVRNLSLSAGMTLLALGDDLDDALQRADQALYRAKRDGRNRCA
AAWENVDA
>A0A173ZIL9|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKTIIKYELVINEALRSALNYHTPDEQINEFIRFFGRHIGSDRIYIFEDCKERHGTDNTY
EWCAQGVTPEIDRLQNVDMDVIKWWYDTFSRGESIIITDIEDIKEEHRVSYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKSDYRGLTTFLDMIGTLLISFLKLRNSFIKSNKEAKL
SSYSSLSKIYTSMHLVDVQTKRYHIIKMTNQVLEYLGKDFKMGKYEIRDDFCGYINDIAE
KMCIESQLQESLEFVDLSTLEERLLGKNSITHEFTDKISGWGRSRFIPVDYDENGRLLHV
LFCIECIEEEKKRENRLIYLAQTDLMTGLCNRGSGEKRITELLKEKTGGLLCLIDCDKFK
SINDNYGHSVGDKVIIAVAEKLQKTCRDSDVVLRLGGDEFAMFIPGMLEQRVAEKFFERF
FENIRQIDIIEMQGKNIEISLGACFYDGYEEVSFDQLYRKADRAMYQSKKQKGCSAVIYV
EEM
>A0A5E7DFJ9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAAEGTGLPLASRLYRSRLLGLTLGLVCVVFGTYPLDPAGWVWAWMLINAFVWPHLAFQ
LSVRTTNALRSERRNLLFDSFCGGFWVGAMHFNPLPSVTTLSMMTMNNVAIGGPRFMLAG
WVAQALGIGTSWLLFAPAFIAVTTHAQLYACLPILMVYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLELEFQRCRRGCAGAAIALIDIDHFKIINDTYGHVTGDI
VLRQLSKVLRQNLRATDLAGRYGGDEFCVILPGMPLNRATEVMDALRDRFNALAYAQDPT
LRASLSIGLAPYQPSHADSTHWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A379JC02|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENLRGKGLSFARRIYRPRILGLGIGSLCVLAALYPLSMPGWVWALWLFNGFIWPHLAYQ
LSSHSAFPYQAERRNLLYDSVSGGFWAAATQFTPLTAVTILAMMTMHNVAAGGKKLMIQG
MLAQLVGVAVAWLVFGPAFNPNVGLIQVYACLPMLILYPVAIGMASYRLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLQLKFHKCQQQQSQATIALIDVDHFKQINDAYGHIVGDR
VLRQLSKELQRNVRENDLTGRYGGDEFCVILPDVSLEQASYVMERLREMFSRYRDPQVPE
LRVSLSIGLAAYQAQFTQAHMWLNAADQALYAAKGTGRNRVTVADSLVARSA
>A0A5V8Y772|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kalamu|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C6AKS2|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MYTVEEIKNKVKTGTWTKEDVARCVEELKQISDFTVYTEEIYYISYGIFAYNFREYAYPL
IEICREAGVHMERSKEKSRLYLALVRLYFCLGFPPKIVEYGLKYANSGFTLRSPLKSVYN
TIVAAFSDCGLFLEADFYLEKMLDISRLDPCDSSVDFWNSDTLNELVYYDSKVYVKLGMG
DVAGAEQAAVDMQAILTEREIPEDGRAFFLLQKEFTDLYLRLYQQKDKAVIAEEFNSYMK
KMEAGEGARDTLSFCVCYFGEFLQVMAEEERWDDIIRIGNYIKNARNFSGSFCPVYKLMR
TAACRSDREELRRQIPEFERMYLEALEKEKENYDQMVRLLTREELRIERLKESMEKDALT
GCLNRAAFDRNSKRFMKNHKKGSLVFIDLDYLKLINDCYGHENGDRYLVCFAENMKCAMD
RQDLLYRYAGDEFLILSALEPEQIQERLNEILEKSPIHFDINGESRNISFSYGVVAFEEK
KGKIADLVKEADQRMYQCKSRNHERISKRGAAE
>A0A5C5Z192|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MLKLYLASLRIAIVVICVGISIVLCTKILGFVPDRLHGDSRSIIQFVVFLVVAGVGAYTL
LVARLMGSFKVSQVVADRVRKSLDAFSEGLLLLDERQRIVVANRALSETIGVKQGRLVGC
KVQSLNWAKSPASATNGYPWVRAAVELQRQSEALIRYKHPEGGYRLLAVNASPIAASEST
PGGVLVTFRDVTVAEEHHAELEQMVVMLKNNREEMRNRNRQLQVLATLDALTECRNRRAL
FEFFELAWTERHQKAGEIACLMFDNDHFKSVNDTYGHQVGDMVLQRVANVLKDSFTDSAI
VCRYGGEEFCVVMTNANAGKAFEAAELARQRIEELRFEKPADLTVSVSIGVSMSGYGAED
PQEMIHQADRCLYVAKEQGRNRVIMFSDAVDKTTQSPDCVCSTETRRTERIKKKETVRGI
VALLDVMEENAYSSKM
>A0A8H9BAP5|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVHSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A250BE24|diguanylate cyclase|EC 2.7.7.65|Brenneria goodwinii|TrEMBL
MDDLLNSNRQIANEETSDNQVILSEWKKLISITSPDAFRLLHTLSKQKSSTLAGEFYSHM
LKDPEASHFLSSQQVHDRLFSSMQKWIEVILTNTGENLDELIDHQKKIGLIHARIGIPIE
LVGRGARRLKWKLYEYVSQQASDKSLCFEAIRFASISMDIAIEIMSTTYSSSHDTAAKSE
ESYRLLSLLNNADVERERQNAALLNWENTFIFNVATGAPLITTQTFEDSEFGLWFNHKGK
PSFGNAQDAQTISEMIKAVDENIGHFNNSIPLTQEAYAPLLKSVRTRIHKIHVFMDSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHETSLAMRKNVPLTIAMIDIDHFKVVNDTYGHTV
GDAVLKNTAEIFHENTRSSDYIFRYGGEEFMFVLIETTQDEAYTFIDRLREKIQNHKIRL
QNNEVVTITISAGIAMYNGHPDYEYLINAADIALYQAKANGRNRIEFAQQ
>A0A221W7A8|diguanylate cyclase|EC 2.7.7.65|Actinoalloteichus hoggarensis|TrEMBL
MTAVEARNSRDTPPDDPLAAAHAREAALEAEVHRLRRDDLTGFLRRGPWGQQAAEALPRL
GAEVLMLITDLDRFKRINDRFGHRGGDVVLHTQARRLRESLPSTAVLGRLGGDGGDEFLA
LTRHDAVDLDKLTQVLARPVEILGRAVPVSASIGAAVRPPGARAPVLADLLATADDALYE
AKTAGRGRCRIHTC
>A0A1S1VBS6|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MLNYNLRKKFIVLFAGLLVVVAISNYYLFLGYSNQKYTYISNQNNQLESQINALLLSREQ
FSNYVFKSLIDNDYIKELMSEAYSSDEATRDRLRKELYGYLQKDYVFSTEYDFRQLHFHF
PDTTSFLRMHEPEKYGDNLGEVRESIRIVNEEKRYVKGFEEGKIYNGYRFIYPLSYNGQH
VGSVEVSISFDALASVLSELYDRDYFFAVKKDVVTNTLFKEELENYTESFFSEDYLFDLG
LLESESKVLALKTVEMIMDESGDISYELEQGEKFGVLSEYGGQDYILNFLPIENISGKVV
AYFISLSGDTDLFHIKTEYIQRTVHINVIILLLFFVFVMHIRNISQLETISYVDNLTKIY
NRHKFLELAESELSRSIRYGSDLSFILFDLDHFKKVNDTYGHNEGDLVLRKVAKIVSANL
RKTDIFARWGGEEFIVLLPETSLENAYTTAEKIRQAVECQQFGKVKKLTISLGVSTVYNC
KNLLASIDLADKALYESKQNGRNRTTVASPGKCLECSECSKDEGSES
>A0A4R8SGC2|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MPLKNVVAYIRSTAWMIFLLQWWTEPVPTGWLRSFLRDRKLDRTVRNLIGGYALIFAGIC
VALQFSDTGPRSTVGRVIVGVCAVGALGWAVRWAVGPWPSLREAVAFVAFADAGIAIACW
QDSDPLAGLVGAVLFTPVGAYVSFFLGNRLLVAHVAWCGPMILALSSRLFAEGTVGAAMT
AVVKVTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYGEWQRLHGGLMR
VHGVQGDRVVAVAIVDIDRFKSINDRYGHGTGDRVLVDLAKAFTGESIRGNTVGRSGGEE
FLVVTICPAHAVVDFATRLREAVTASRPAGIMVTASVGVAAQPVASVAAATSREAIDVLT
ACADRAMYEAKRNGGNQSRILHPEYESGDHYLWQPGV
>A0A1R4B378|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MVKERVYWKFIGYFVVFGVSVLSFSLYLLDNFFDQLQQQSIAESTEFQQRRADSTLDYFT
QSALRSIDNVNSNQWLLQDTADSVEHVTPKLERWMFGVISASKANYRIEYYDTNGRVQEA
MYVDKRNRLVLDTESKGIKRITPNEWPMSTSTPHLAQLSSIRHSSYYRLDDQPDIPLVLG
VVPIYNDKTLSGYIGLFVNMTLPLKVLTTNAQLDLFLVASNGDIIASSHTPASQADNQPY
PFTLQHTFNIVDINASKELQEHQLTRYKLRMIRSRDSISLYSRPNDHFLNAKAEERSAYL
AKMISLVLVFSILFGSFLAVKPSRMISRLKRVSKERDQYLKIMDQSVPVLKTDLTGNITE
VNSAFSLLSGYYDRELIGKTADVLSFNPEEVNHDEMWEVLQAGLSWQGEFHNISKSGHEF
WLFSTILPIYEYGKLSGYMAVSSDKTEKKQIELMAEMDSLTKIYNRAKIDKCLAQEQERA
RRYGSKFSVIMLDVDFFKSVNDTYGHLVGDKVLYQLAIMLNTNTRTVDEVGRWGGEEFMI
VCPETALNEAEHVAEKLRQAVESYDFPDVGTITVSLGIAMYTGNEDLKRVLAEADAYLYE
AKRLGRNRIASRLSNIVPLNKTMRF
>A0A6Y2X0T0|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
WRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A654AWE4|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. T1|TrEMBL
MRDAQGAQQVSTEDLFDQIGRFLRKHRLRPDPSHYAFAHAVLSAPDGPLAAQVAQLTEGG
VRLLRRDIEALGGQVTEPSAVVDPDDPCDPAQREGQADRLVAETQEYVDGFATIMHSIHA
ETRGFGHDLAESAAAITTSPGLAEIDEITRITTAMIGRIRESEVRLAKAKHETDVLRAKL
IEARDSARRDTLTGLPNRRAFDEAFGARDAGKGPYCLAVCDVDRFKRVNDAFGHGVGDRV
LTAIGQMIAAGCEGHLVVRHGGEEFAVLLCGVSLSDAARLLDSVRAIVAAKRFRNRETDS
PLGQITFSAGVTAIHADEAAESAFARADRLLYTAKGDGRDRICAA
>A0A210P9Z4|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MLTKIFLDNAPLITSLFFIMGAFIVFQILFAGVRLIFKVIHRNIDKYLIRSILGIIYILS
LLFIMQLSIRDKNQSWIYINFQLVSIIFYTVILSVPFKYHLFGPIVVAFMIFNSALNSWE
SWCSGIVLISFYYSLNYIKSHTKNKFPFFPYLLVSLILGSAYWFLIKIKFSISNPIFFRQ
VIYLFIIELFTFGYIAILYTDLESRAALFRDATHDKLTQAYNYDAFDIDFRSLFKDNVIS
DGKFTMMMFDIDHFKSINDTYGHLAGNKVLQTVVEVVQSVLAKNDKSIKLYRTGGEEFNI
IFPHYHVKETQTIVKEIFEAVNHTEVDVDKNKIHITISVGVSEISKKDVSVNDFYSRVDK
ALYHSKRNGRKEITII
>A0A7H8UEC6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVKQEWVKLINETDPEVHRLAAELAGDNATALIDEFYRIVLADPSVAEFLTTEQ
VERQLQEALRRWLTDVLSCEAGQVEEQIRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PIITTSPHSSEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLTWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDETFERIRQSEQGLNDNVHRDKFLHQMRNSLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHASRAGTRLSTLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEADTLRIAERIRKRVEKIKVNSPAGDIIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKEA
>A0A800YMT8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLAGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A8H9CD02|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MALHSKKLSFTRPIMVSFAGILFSFALIAILVILSQRKDFLEDYHKINGNFTHNLAVNYT
ESILRENDYILGRAAMYFARNDRVNQTINIDPTHGLQMLMHLQNLMPTVSSISLADTEGR
HLRAPEVLPTEKSKSFDARTRPWFVGQAEASNFPHYTRPYLDYFTQHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLFDPKSKTWYYYYSFTNPDWFVIYRVSDATLNVITRHETTVVGWGFALAAII
IILFGLYLRHASRSVLMNIINAIKTGDVNQAPRLEAMLSHTIRTNKERELAYVRQATHDA
LTGCKNRRAFDNDVDELLTAHQPFVLALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFGVIFPAELMNSAHALLEAWRTAVEKRTWREENLRVTFSAGMGEW
HFEPLEQFIGSVDEALYTAKQQGKNRIVSTACR
>A0A1U7MEC6|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MNNTWKLKKISKRIVLMFFLTVTLCSTIIIISVNNRYSADKILMDQLIQEKSNQVNTVIT
RLLYKTETLSALVVQADGNTQNFDKVAAIIFDSPALVNVLLAPDGIVRDVYPQKGNEGVI
GYNLFGEGEGNIEATMAKESGNLVFGGPFNLMQGGQALVGRLPVYLDEPDGNKRFWGLVS
VTLGYPQLLDEVRLSEFESAGFLYEIWRISADTNDKQIIAKSAGSIGEHIHYIEKYVPIL
NAQWYFRIAPARQWYDYPEIWLMIIAGISISFLVALTSQQNVELKLMGTELENMSRIDAV
TQVYNRRYFMDIAAIQAQRSMRLKNSCFIVMMDIDYFKKVNDTYGHTAGDKVLETVAQRM
KHLTRPYDLIGRYGGEEFIMLISDLDKQALLNVVERIRLSISENPMEIEGNYINISASFG
VADVTTLNDLDNGIKLADSALYTAKESGRNAVIFYKDE
>A0A377M869|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MTLKLTGNVVVLSSGSLEWWLTLPVLMIYPILFAWVSHQTAIRLAENKRKLELMSTRDGM
TGVYNRRHWETLLRMEYEKCRRDHCQTTILLIDIDSLQEHQ
>A0A144NT55|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPYRAGIQFSRRVRLARAVGLAAMFFPIAGMLVTHF
LPGGWWLLLVGWSFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGVMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGILLTLLSALVTLPLVGKVAVFNPDPVEWGLTLPVLMLY
PMLFAWLSHRTAVRLAEHKRRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHGTATI
LLIDIDHFKNINDTWGHDVGDEAIVAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLEKLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A1U7MFG2|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MIQHRQTLKNISFILLFILLIIGLSNSSHAASNIFLTEEERAYIAKKGVIKAVSLDGVAP
IQYSDKNKEVQGISKRVLQEISAITGLTFEYTLYGSLREVFESNAEIAFGIPNNYAPPDM
ILSKPYLRSETILYINAAQDPNNLDNKIYAAVRGSALPKGIKEENSIYFETREQSLDAVE
AGRADYGYGNAYSVAFYTLQNGYKNLVTIPKGKEARAYCIGFFHEDEILISIINKALSEI
GENQLQNLVLDVAAQVERKITFSMVINRYGKEITFIIIGVLSILLFAITSNVKANKTLRM
NNRRYEVLSEISNEYLFEYFTKTNRLQLSESFIQQIGTQENLNEANRILKNMLANTAADR
QYFEIKLPLANGEVGIFKVIHLSVNDDNGNLVSIIGKVVNISDEAAKREELANKALLDGL
TGLYNAITTKELIQTAICSRQEKQRIDAFILIDLDYFKDINDTHGHLAGDNVLLQLGKVL
KQSFRTTDIIGRIGGDEFCIYMPNIPSLDFVKTRCQKVSTLINTAIEDIPVTISVGITLV
DQDMGYEEIFKSADEVLYQAKRDGRNQIVAWVEK
>A0A1W6KBX3|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MSQPDNTGANRSPAQNTEREQKLRIRRLGMSFGSYMVTFSIVVYCWVQGLISLGVTVGFL
AFASLINATFWWLIHTGRNLKFHDPSMTSAQMIVSLLPPIWVMAFLEAGQARAIFLLIAV
VPMLFGILALTTRQFIVVGVWFFALYGLLHLGLWAYRPEVLNSELEILQTVAFALVMAEI
TVIGGFISSLRGKLRQRNLELGEAMEQIRELVNVDALTGVYNRRRLFEVISEESNRYSRM
PGSFSICLMDIDHFKEVNDTYGHQAGDMILQAVARSVKDGLRTIDCFGRYGGEEFLLVLP
QTPLEGARIKAERVRETIERLTFPDIGDDFRVTVSIGVAEYHREESTDDTLLRADQALYA
AKHDGRNNVKLAATRIPQKSPLSAPSVRPI
>A0A8I2CKU9|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPTPFSDIKRRLLHRRHALLTGASGLFLILLGGNVVAGWLLRLAPILPENIHMVISTASC
MALYGIGLLLALWRPHGRAHRLPVLLILLIVAMVAAEHLSGRQWWIDFPELHAWRHDVVP
IPGRMAPTTALALAMLAIGMWLLPAATPGRLQALRACVLAPLLLGALGAAAYVINLELLY
SWGASVRMALLTALGVIAASLGLYGLAQQAQRRHPRSQDMADSISVTATVLLVSIALTTG
LLIHRVSSEAHEHSLRTMMSNSVKQRAALLTTQFGISGDIARRIYQRPAVQKLLEDASNG
RLDASAAAAELAARNHMTLNGIAIEDGGGRTLVQVGYFESRPRQALALRSPAGAQLLWNG
HYLYRTVDVYRTSAGSSRLVLEQRLDMFDRVVQDTAPRDSLSGLYALCGHDQHDLRCFSQ
SPRDPGTTIPIAGNIHHFTMWPAFFGKSGSLHTVDYSGRDVIAAYAPVGDSGLAFSYKIR
VADLLAPMRRDLEINALIMLALVVVGTLILRWRTSPLLREVLRSNQMAEMAAERFRNAAE
ANMDAFIIMEALRNTAGEVDDFRVVYLNAEAERMWRLRRDETIGRNWKALAAALDVPNHF
ESYRQVIDTGLPLSEEVPRAFDVSHPSWIHQEIVRAGDGISISVRDITQKKLAELDLVLR
EALLKTVTDSIPALVAFVDADQRYRYCNKTYTRLFGIPPEQVIGREMRDFLGEESYAAVR
PHVEQALQGQAVSFEMEMHLHGSPRYVEGRYIPQQHADGTVSGFYVMIWDITQSRAREIE
LRSQVTQDAMTGLLNRAAFMDILNDEIKHHYLKRQALALLFLDIDHFKQVNDTLGHAAGD
ELIKIFARRLRQNVRGTDHVARLGGDEFVVLLVGLDAERTATAVVDKLMAAVCRDAELAG
KSHRVSTSIGVAYAYMPDITPERLLKIADEGLYQAKSAGRNTYRLLRVG
>A0A8I1YWJ5|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MTPRRFGSRSARHAKWGAALLLLVTLALLAVDLSTSYRQLETEAGRQASGLSQLLAERLS
SGIHEAGLILQSSNQIPEVQHLLRYGSLDTDARQNLAQKLQQQLQLAPYLSRIEIVDTAC
QTVFSSKRDGAPHPHHNEFCRWLHRVDPKESNYTTVIHSPTEGGIVLANKLYDSEGNLIG
MATGLIKHNFIQDEVSRLTVGEHGEILVLDQRQLTVTRWPQSSRNDPQSYRSLQPREILS
HDPGQMLFDAPSSFDGGERLYSMRQTGSYPFQVAVGLSRRDFTRYVRDKAWLAIPGWLFV
AALTLLALRKHLSNLRQHQQLLQGNERIRDSEEQARLILDTAPLALLLVNPQTARIRHAN
SLAREMLGLPPRDPEQAAGSELNLPLKLQPVEQWLSEGEEVLQQEVELELEDKSRLWAIV
SLRRLGHDSQPSALIALYDISGRKLLEQQLHESNQQLAEMAVTDPLTRLYNRRHADMVLR
DEISRCERYGQTMAIAVFDIDHFKRFNDQYGHQAGDDVLVAVANALRDTTRNTDINARIG
GEEFMVIFPYTRLRDAHKVMSRLQMALTHTTFPFVEQRITFSGGVTDWRPGDSPALMMSR
ADKLLYDAKQAGRNVVLSDQEEA
>A0A1Y0HR60|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MLRIGVPWAGRDFDNAHSSSIEKPIPSSEITFLPLLKKVFFEDRLYYIIANINIDYLTNR
YTNTLPIDQGTVSLWRLDGTLLVSTNPQLYLGASHYNLSHWQQENEDFFAHLRDETHSLL
DVFRLAKIFPFIVEIQTNEVNTLGYWDKERQKMLGIIILLMTLTCGLTLALIVRYYNENS
RQREQLSYEKQFRVAMEATQTGLWTWNLKTNQVTWDTQCFLLLGYQPHSFETPWDKIYEL
THPDDAQDMLPSIQDQILAQATFLIERRMKMASGEWVWIQVRGKVIEFSEQNEPLLLTGV
YINIDTQKKIEQLHLSAVAFETQEAILITDVKEKILKVNEAFTRITGYSDNEILGQTPRV
LHSGYHDKAFYQAMWKALLEEGFWQGELWNKRKNGEIYAEFITITSIRNDQGTITHFIAN
FNDITTNKVEQLKIQELAYYDPLTRLANRRLLEESLHKTLKHCLYESHLGALLFIDLDYF
KELNDTFGHDAGDMLLIQTAARLKETIRESDLVARLGGDEFIVLLKDIGKQHGSANHLTE
NIAHKILSLLCKPYALAHGNYQLGASIGCTIFGNDPKKDSTMILKEADLAMYQAKEKGRN
QICFYKTSS
>A0A4R2FDM0|diguanylate cyclase|EC 2.7.7.65|Shewanella fodinae|TrEMBL
MSGTTSSKVANDWNTLISGINPQSIQLNRQLVANHSGELATQFYAHMLGAEDASIFLSHD
QVKTRLHGSLQQWLITLFDIDEQYDLAAAVALQVKVGEIHARIKIPMHLVLRGARYLKQH
YGELLQQEPLTAEQQHECLQHFCDTLDVSMEVMAQAYASSYDRNTRSDEVYRLFSISQNL
STEREKQKGALLDWENRLMFECTLGNPNAELPALSTSEFGLWFTHKGAHAFQDYPETQLI
DERINIVDEQLLADMQQGPADTRIQSLRKVRDETKRIKFLLDDIFAKSSELESGRDVLTK
LLNRKFLPTVLSREITHARRNHSQFALLSLDIDYFKEVNDSYGHEAGDSVLQQLSGFLVS
NSRAGDFVFRLGGEEFMVVLVDVNKHNARAIAENMRNKVSAENFMLPNGERIQITVSSGL
ALFNGHPDYQVILRQVDKALYDAKHLGRNRVIVADTDQL
>A0A1V4IKT9|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MVDYRQLYKKIKDEFEVYQNFTEEKLLSLTNKNIELEKNLDAMANIVEISKYINSSIEDE
NLISMINDMIIGILGVMYSTVYIKNGNEIEIMATNKKDKSHIYFDGDKLKLLEKDEPFVI
NSKSSVHGLEEENYDINIHSVIGVPIRLREKFIGYIVVEHTHFNFFNPEHIKFISAIANQ
IAIAIENNQLYQKIKELAVRDPLLGIYNRRYFFEEVLKYIANNKERSFAVIMVDIDFFKL
ANDRFGHQFGDEVLRSTSRILTESFNSNSMVARYGGEEFVIFVPEIINARDVWTEVENTR
KRISENMVRFGDKHYSVTASFGVSFYPYNGTDIDSVISNADNMLYKAKQTGRNKVMMSEF
SHL
>A0A0M7HDP5|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MLDPILAELSTTLPEAKSVEQLTRPLLDMLGAVTGLESTYLTSIDLKADLQSIRYARNAG
TLQIPEGLSVPWDDTLCKRALDEGRMCTSDVSSCWPDSDAARQLGIQTYLSAPVRTDDGV
LFGTLCAASATRHQIEPQAESVLKLFSSVIARFLEREMLMEQLHAANVQLMSYALTDTLT
GLPNRRALYEALDRLQARAIREGGSVLVGVIDLDGFKGINDVYGHQQGDVFLQEVSRRIS
AALRGSDMLGRIGGDEFVLIGPGPALVAGDGPHGVHAPRGDAEEAARSLEERATAATVGR
YQLGEATVPYEGASVGVVALDPRGLDAEAAVRLADARMYEVKRARKAARVIH
>A0A0M7M7P2|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MWGLATALALPLLAPLRARDVGGVAAFTAGNALAVLSLLAYAASPILPSAVYVMVSNAAW
VCAVSLVYVGVRQFFGLRPLARRTAALGALSIAAFALLLYVADDLRARMLLFSAYTFVAM
MATGMVFFRQRKRLHTRGVMLYMMLASFGLAALHALRLAVYSVGGQEPSSLLEPSPWGLF
FIVCGTVTVPGLFLALLLLIQTSLSEQMEAALTFDGLTGAYSRRSILDELERELQRCQRA
GGKLAVLVLDIDHFKSINDRYGHAAGDAALRHFSKVVQRAVRASDRFGRLGGEEFVLLMY
DCDPARALVQAQRVCDALRDTPFHLQGREVRMTTSGGLASYQSGDGADGILARADDALYR
AKEHGRDRVEMAWIGRPAGRAQERGPAVVEEEVRA
>A0A6H0KI04|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei|TrEMBL
MQSYVARVREEWLELLRDTDSDVQASAKALADAHARALSEVFYQRMLADPQAEEFLSNDQ
VETRLKKSLALWIQRVLACKADEVDALIALQQHVGEIHARIGIPIQLVDMGARVIKKNLI
PIIIAEGGREDEKMKLLSFTLCSIDLAMEIMSRTFTFGESSSLKDDENYRIFSLLENAEE
EKERQIGSLLSWEMDVMYKVMLDSELGSTPPISRADFGMWFTHKGRHYFSGIAEVGYIAK
LIQETDELFSRFRDPSRTAKQKHQRTELLLQMKSNTAQINTLLRGLFDDVAKHEVGMDVL
TKLLNRRFLAAIFKREIAHANRSGTPLSVLLIDVDKFKEINDGYGHAAGDEILRKISQVF
YDNVRSSDFVFRYGGDEFLIVLTEANQTETLRIAERIRSKASRQSITTPDGKLLATTLSI
GAAMFDGHPDYERLVQSADAALYRSKRQGRNRIEMYILGDTPYS
>A0A840MYT0|diguanylate cyclase|EC 2.7.7.65|Afipia massiliensis|TrEMBL
MSARVLVVDDVLANVKLLEARLSAEYFDVVTANCGTQALEICERAECDIVLLDVMMPDID
GFEVCRRLKSNPKTHFIPVIMVTALDSPSDRVRGLDAGADDFLTKPVSDVVMIARVRSLT
RLKMMTDELRMRAITSLEIGVNAPERDAVADTGRGGRVLLVDDRPSSYERLAPVLATEHS
VDVEANPAEALFHAADGNYDLLIVSLGLENFDGLRLCSQARSLERTRSVPILAIADADNN
ARLLRGLEIGVNDYLLRPVDKNELLARARTQIRKRRYTDHLRDNVQNSIEMAITDPLTGL
HNRRYMESHLSTLAEQAAMRAKPLALMMLDIDYFKSINDNYGHDAGDDVLREFAVRIRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGESFAVEKGAKRIEVTISIGI
STLETKGEAIGAVLKRADQALYRAKHDGRNRVVAAAA
>A0A3S9L1K1|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MSRKKHRQNKRFLLVLKQLALLLITGLSLVISNWSLADGWYRELELIDEVRSADPATFAK
KLTAIEAHLQEMNQSELDYFEYLKAYALTYKGDLAKALEIQSGLSQNAESKEMRFRALLT
VINIHAIQRNWNDGLSSLNHALTILPEIESDKLRAMVFGIASIFYNQLGQYSLGLEYSQR
FKETKTDLRNQCAAEQLRLEAMLQLGEAPKELASIYNSGIQLCEAANEKVIQSNIVRLYG
RHLLETDNQPLASKALLDENEALVLSAKYAPVIASYQSLQAKANWELGQQEKAYQQALAV
NQSPAAANALEALIRANKVLFDYHSSRGNSEAALEAYIKYAEADKAYLDEVKAKTLAFQL
AQHQSLEQQNKIALLDEQNKLLKVQQRLDTAERFNSRLMIGALLSVILGLITWGWHSLKN
QRRLKQLAEYDSLTGLLSRGHFTQVAQSALTHAQTLKAPVSCVLFDVDHFKRINDCFGHA
TGDWALKQVASLCREQVREFEIFGRIGGEEFCLILPECDSAHARVIADKLRRTLASCDTS
ASGNDFVLTASFGLTDSQQAGYSLDQLLAQADRAMYSAKRAGRNQVKAYSRDDDEASIDQ
TDEEQTQAGPGRQSHVQRQTRRT
>F0JTZ4|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii ECD227|TrEMBL
MENRSWHKKLARRLGPGNIVNICFVVVLLCSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKQLQYNVDKLLFLRNGMHEALMTPLNFSALQNAITQFQQNRNKRYWQIGLDRRRTLMI
NGVSDDFVSQSNLLSRADDDLHNELTAALEVGYLLRLSHAPGAAAQQAMYVSRAGFFLST
QPTSNSKDILTRYFDFVTQPWFNEQSERMNKSRGVRWFSTPGDHTNETKPQITASIPLDN
QGYWHGVLAMSIPLAAMRSLLVNATHNDTDGEYQLYDSKLNLLTTSTPEQRKINTFDDRE
RALLAQDIEHDTQGGIRMNSRFISWERLDHFDGVLVRVHTLQEGVHGDFGSISIALTLLW
ALFTTMLIISWIVIRKMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARFLAQECREN
QRPFSVIQVDLDHFKSINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEEFCIVLP
CANLAQAQEIAERIRLRLNEKEILIARSTTLRISASLGVSSTEETGDYDFEQLQSLADGR
LYLAKQAGRNRVCASDQPLSEDKK
>A0A645J206|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MTDLFNHKHICRRLEEEIRRANRYKTPLSVGIFDMDGFKNINDTFGHQEGDRIIIKATET
MKQTFRETDLLGRYGGDEFLVIFPETPLGNAVKAAERFREKILQNIAEKDKTISISGGIT
FLQKEDTLQSLIHRADMLLYDAKNAGKNKIAW
>A0A3F3S0T0|diguanylate cyclase|EC 2.7.7.65|Tissierella praeacuta|TrEMBL
MYKGNFETNKVIQIIINQEYKINYSNIGNERAYNYIKELNILQNLSIDSTIPYTLGDYFV
YIDKFYIYGQIYYIITISSNSSKCYSCSKVLIDDVTGLYNRSYWEQINGEIQKYLSFKDL
FLILIDIDNLKKINDSYGHLEGDKAIKVVGQAIQKSIRRDDIGIRYGGDEFIVLILNQYK
DRAYKVIKKIRREVYKQSVEENIDIQISTGIASNINSCDIEEIIRIADKDLYKEKKLKKG
EKQEEIHKFKELKKQIENIKNDLNKQRIKKDKMEIFELSQRLDKLIMKYLKDI
>E6WDV9|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. (strain At-9b)|TrEMBL
MAQSPLPRQSGNPFLPVHLCFLAVFLFSAFLTVHEALELKTSYEDRQRAQLAEIQKNLDS
QFQESVDELVYYQKMLSYALMHPLDSDNAREAVQRFQTLRQRPLWQLQLNSPRSMPLNGV
GDAWLARDPLLKRDSALIDQEIRAALEFSFIMQFSDPDHDFHSRFWYISRAGFYISSRPP
QSPQELEQSYATMVQRAYFRALDPQQNISPQLRWTSGYQGLFDEGLMLTLSAPIISNGYW
YGVLSMDFPQARIRNLLAETRHTLLQGNLVFLDRKMNEVTRLHAPDEIPLNAEHRQELLN
RMQHERSGILRLGTQFASWSKLTNVDGYIINVQTLKQGMKQELGRVTLFLLSMWLLFILM
LAVAHQVIFRLVRRQDELSERLTWRANYDGLTRLLNRSAFFEQFVAQAAHCQQLQRPLSV
IQLDVDHFKKVNDTWGHHAGDQALIRVASVISHTLRKYDVAGRIGGEEFCIVLPETTLAE
ASAVAERIRARLAAKTILVNASTTFNITLSAGVTSSEEQGDYDAESLQAKADSRLYLAKT
NGRNRVCSAD
>A0A1F2LYF5|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. HMSC16C06|TrEMBL
MDKPLRLKINKLRHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTL
PVFGVSGSVVGNNPILLKDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMTHYSQAIGALWFSRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLAVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVL
PNTTLQDAVAVAERLRLRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADR
RLYLAKQNGRNQVCFRSEA
>A0A178G342|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SFB|TrEMBL
MNTESIAMLAEQWKSICAGYSTTDLNDTFQFVQAHSLALVDEFYKNIMREKEASYFLSDN
LVQNRLKATLNQWLVDCFNVPFQQNFEEISKKQLVVGTVHARIGIPSWLIMRGVREIENK
VFNLQSCKVQQNSLVIINYIIQVLGFASEIMCRSYEVNIEKSNDIKHTYRLFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSDKVDFKHPLLSKSEFGLWFIHKAAYAFTGSEQVDVIIE
RIYEIDQLNENVLACVEKDKTIELIQHIREKSREIQHLVDQIFQVAEYIDSGNDSLTQLL
NRRYLNTIISREINFSRKNNVPLSLLAIDADYFKRINDKYGHAAGDLALQFIGEVLLESV
RGSDYAFRAGGEEFLLLLVDSDLTRAQEIAENIRTRVQKTPIRTAAGSSFNFTVSIGCSL
YDGHPDYQRFLDAADSALYAAKNNGRNNVYLGK
>A0A1S7RB60|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. Kerr 14|TrEMBL
MFTVLECVAIQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVFAVIGFWLALTARSQAAYSPVIVGTLITLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWVSFLLAFFLFRGIGSWKRIAAPAASAI
FAICALHFTTMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSSTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGRDEASLVGQNPDDLFKAIDGQPAYLP
RHTPVEAVRERAGQAQIFELSVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDEDDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTRAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGRDHESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKVAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKTT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVRTTTRKKHSV
>A0A0W0YR85|diguanylate cyclase|EC 2.7.7.65|Legionella santicrucis|TrEMBL
MYFTLIMIIIGIFFLLGGAIVVWPLIKKASYYHYQWIANLVLICFFIGSFLFVIVYTLLI
NEFFTNYFYATLFLLGGFYVFWMSYLSSKTIEKIKTMDNLKLEYEKIRYNAEHDKLTGCF
NRHYLMEILDNRFRKIKLNTGQLTVMFVDLDGFKKINDEYGHDFGDQILQRFGQLLKQQL
REEDIIARYGGDEFVVLVENIPLTKAKSIGQKIIQTTSRITKEKLPNHSSLGCSVGITQL
TKNSLSINSVLKKADDACYKAKKNHGNTIWVDDNMTSSFLD
>A0A7X2LIH7|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. CAH-2|TrEMBL
MPSFYANQWRRLLSSFSPQIRCLVAEMAQAHNQALAEHFYSAMLEDEAAVGLLSHEQVHA
RLMGSMRQWIAQVLSAQPEDDLEPLVQHQVKIGEIHARVDVPVHLVLRGARRLKDGWHHL
LAQHHPEQQTLASQMVAAVIDHAMEAMSQGYAVSRDSNSRTKEAYRLFSVTQNLTTVREQ
RRAELLAWENQCLYLHALGAESQPLSSLASSNFGLWFRHKGADMFQGAPAAQSILDAIER
IDQELLPALMGAKSGEVAQPLLQLHEQVRHMAMNLEALFTQNSELDAGRDVLTQLLNRKF
LPVVLSKEVSYARKSAAAFSVLTIDIDFFKQINDQHGHEGGDMVLQQMAALLSHNIRGGD
YLFRLGGEEFLMVLVDTGSEGAQRVAEKLRKQVEQARFQLPRNQTQGVTISVGVATFDGH
PDYQRILRQSDAALYRAKTAGRNCVQVAELEG
>A0A0H5VS30|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNQRMSLTWIICAPLFIVFVLAASVFQQYLYDLNQEIDDAYADIQQQLERAEKVVTALDY
TFTHNQRPAENILFKHSARVVANVCQIKPIDGLVLAQGLSSSFAVPKLDLSYMLIGDASL
CDSKPSHDPSLQIKLSMAPILSFLHDMDEYIYGVHYVDSSGYIISSPDTISEKVTYQQIK
DFISESPLWSHAIAAPNMIAVDGPYRSVIREQHEWLLTLILPVYRDADYQGLVAVDIGLR
ELLSRMPHLASRFDMIDLNEMAIPTFAYRPHKLTSEYADYHQVVFYKLDIQSELSNFLTE
KSGNLLVVALVYLFLTGVLIYLNTRWDRQHYAQLAARDPMTGLLNRRGMESFLKGKRHSQ
YLAIAVLDIDDFKQINDAYGHDMGDRVICYIGEQIENHIRSSDAVARFGGEEFVVYVTAK
EKEQITRIMQRIFDAVCRESPLILEPGFTISGGIEVVESTTDRSFEDLFKAADEKLYVAK
TSGKNQLVY
>A0A1T3AHR9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRLGKGLSFARRIYKPRIIGLGVGCISVVGALYPLAMPSWVWAFLLFNGFAWAHVAYQ
LSVRSPFPYQAEQRNLLYDSFFIGFWAATTQFSPLTTVTIVSMMTMNNVAAGGKRLFLRG
LLAHAAGIGVAWGVFGIHFNPSVSLTQVYTCLPMLMLYPVAIGMVCYQLAIKLSEHKRAL
SAQSRIDSLTGLLNHGSWKDLLNLKFHKCQQQHGHATIALIDIDHFKQINDTYGHIVGDA
VLRQLSQKLRLHLRQNDLAGRYGGDEFCVILPQMPLEEAAQVMEHLREIFSNYRNAQIPE
LRVSLSIGLADFRPLYSDAAMWLNAADRALYAAKNTGRNRVTVSDYVIAHSA
>A0A7Z1I9V5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDMKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFSLTNLLSTFMMRYPGAL
LARYHRSDFAVLLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCERSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLALVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1Q8PS65|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQKLQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A0W0TVZ4|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MIKPKLPKNEAERLHALRALQILDSSHEERFDRVTRMAKRLFGVSISLVSLVDENRQWFK
SAQGIDASETSREISFCGHAINQEGLFIIPNALEDVRFIDNPLVINHPNIRFYAGYPLKL
RQGIVLGTLCLIDSNPREMNDEDQQLLKDLGEMIEQEIKSIQLATLDELTMISNRRGFLT
LADHSMKICRRHKKPMAFLLFDLNKFKIINDKYGHHEGDFVLTMFAQIMLESFRECDVVA
RLGGDEFVTLLVDCDDNEINTILKRFKTNIENANATLSKPYNIEYSSGVAHFSYDTDKSI
DEMLQEADAAMYEDKQGKAR
>A0A2U3Q0J3|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium vignae|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDMD
GFEVCRRLKTDPATHHIPVVMVTALDSPADRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRESSYERLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQAATRGKPLALMILDIDYFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSHAA
>A0A078LE12|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MTAQSWRALRTKKYQFSLRLFLFLNAVSGLFTLVFPLYEVRAVSVPAILLFVASTLLLIW
HGKYTHKKINIPFISVISGILWAWHITLKYNAMNHSDYTFLLIALLCVLFIGSIAFANNI
IAFTFHSLPSVLACLWLNGSEHGIRIIYLMALPMAGIAIQHVIQKRYDDFAQQLMYKLLE
ERETLNGLSMLDPLTGLYNRRGLQNKLNTLLALETHEEHYVLLLDIDHFKAYNDHYGHMM
GDQALIRVSAAIRDAVRSRDIVTRFGGEEFMVLLTATDPQEARTTAERIRQKVYDLKIPH
MFNVSVATNVTISVGIAPLLGQDMEAAIVKADKALYEAKNLGRNNILASDELRTV
>A0A680P5Z8|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQRAEKLVK
>A0A602UZC9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALTQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A380G3N5|diguanylate cyclase|EC 2.7.7.65|Staphylococcus petrasii|TrEMBL
MIEAIIYNIAVMVAGIYLFHRLQYSENKIMVFSKGYVTVLMTLVALLLAAYPIPFHHEYL
IHLTFVPLLFLGRYTNIGYTLIAAIIIALVDVFTFGNSILYGVVLIVIGLISSMVGPFLK
QNDIVSLIILNLISVIILFILSIFSPLYDLIEVGVLIPISFVLTIASAITFVDIWHFFSL
VTRYENEDKYDYLTGLGNVKEFDRHLNKISQLAEDNNESLALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPRQFKIFRNGGEEFSVVIRDYSLDQSVKLAENIRTGVEKSSFH
LPNREVIKLSVSIGVGYLSQEDHKSQRKVFKDADDMVHVAKNEGRNQVMFNPIIKL
>A0A3V3CM70|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Havana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7H4MB43|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIATFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAATFFARNDELNRAVNVDPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLKNEDSLAFDPKTRPWFIKQAEASTFSHYTSPYMDFFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSDELMD
KMTSGEGQLYDVRSDTWYYYYSFTNPDWFVIYRVDNATLINLTRHETNLVIGGFSLAAII
ILLFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A173VNU1|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MSSNDSTAKEQSFLFNVNKIFLVIHLLMLFMFSSLGVDLMAGVSLISICFYFLAFSLTKS
EKLSIYVYSVAVEILLYMILAVVCLGIQCNFQLFLIDAMFFLFSMDYVVLRKKKKNHVAI
LLCCVYAIALIILYMLDGFYAPLYKLDSVVIKSISIAMISGVVFLIITCMMCLLHFMSSE
EGAMEKQAQFDALTELPNRFYMMAKLKNLFEAEKQGEYFLAMIDIDDFKKINDSFGHNVG
DDALKMLARTIVNKARGVELSYCRWGGEEFLLLGKCVDGEVPKNFLDELRVEINSKSFWT
SKGSGRMTVTIGAGKYKVGQDYKEWINFVDKQLYVGKCTGKNKVVC
>A0A8F4WWP1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MKADKVRPTLRSVIGRGHLILALVAVILASVSLTLLGVLALRVYAEHNLHLIARSISYTV
EAAVVFNDSAAATEALSVIASTEEVAQAEVLDANGKLLAQWVRPETSMLSRVELELAHTL
LEQPISQPILHQGRAVGSILLTGHGGSLLRFLLSGLAGILICTALSAWVALHLARRLLRG
ITGPLQSLAAVAHAARSERDFDRRVPPAQIAELDSLGSDFNALLGEMEAWQSHLQSENEF
LAHQANHDSLTGLPNRAFFEGRLIRALRSAAKVKEQVAVLYLDSDRFKEINDSFGHAAGD
AVLVAVAQRVRAQLREDDLVARLGGDEFAILLAPLHKVADAERIADKIIASMDLPIPVPG
NTEVLTSLSIGIAIYPDHGATPGTLLNAADAAMYQAKRLSSGGQHTAESEHAAVNLQHRS
>A0A443UAS8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>A0A2J4ZQM6|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MTAQSWRSHYEQKYQYSLRLFLLLNLVSSVLSLVSPLFTVITFTLPCFLIVACSTVLLLW
HCKFSQHKINIPVISLLFGLLWAWHVALKAMVMGPPHFNYLVIALLSVLFIGTIAFSSNI
IGFTLHSLPTYLICLILGGGEQWLRMSWCFLLPIAGITLQSLIQKRSDVFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTILSLDGAGHYVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTSSCAENALQAAERIRQRVYDLKIPHM
FNESVATNVTISIGMTPLMDADIDSALKRADNALYEAKNMGRNIILTS
>A0A5J1RZD4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0K0HPZ7|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MKLSDDISTRSTNFHHFITIASLVVSLICFVMFYYKIDKMNSDLEGVLSISIMKSEYLTK
INDIIYSRVEKDESYQKNVAGIYKTYVSDIFNSKISDAVKFEEEHFAENIYLKARDQDAR
QIYHDIAIDNNRFPELAKNLLDQTKATYNRQLIILILIPTLMALLRCIQSIYYFYSLRKL
RGNYMIDPLTGVYNRRYLPRIRETEGICYILAIDVDNFKTVNDTWGHAFGDTVLQQCTYR
MKEHLRDHDIVVRMGGDEFSIFLFKTDEVGAQRAAQRLLDTINEQALELPDGGTFTPSLS
IGMAKCHGNVELAMNIADQNLYKSKKKGKNTISFGGDK
>A0A3V7KTK1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pomona|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3X9BQC6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2S8DL24|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A086I2S8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRAIHIYDSEHHLIAQSFKLSSQTSVLEKWFDHWF
LNEPVHLTIYHHQQNVGELTLFGSSEKILQFLKMIMVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQILLDMFEDKDFDNKSALLFIDNNNFKSINDQFGHLAGDE
VLKEMAKRLQTRLRHQDFIARLGGDEFAVILHSITHADHLISIAENLLESCKEPLHLNDQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKTSEQHWFIYKPEN
>A0A0E1FPD1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
TVWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAVCTYLSMTGVISYAPLF
NFTAMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIAQCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSTFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A335J9Q8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIGSFAGAFTGYMIADLVNGTPLFLTLILTISNYLYVVTTLALAILFHRHIKAAYQGYS
YLLLFALCGIGSITGALFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKNHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLGNTISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTKEAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A3U9AI96|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7T9P679|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLAGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A0W8A639|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A8B3UZL4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRYYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A155F5A3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNIEREAVKQRQVFDQLTEEIETDTWMLS
DLARLYVIQKEPEVLEKYQAKEAELKNIEHTLRQLKNTGASGEELALLYDGLKIVDDLQD
EQQAAIDGIARGEEQQAVSLLFGKSYELELERAHNTIERFRMLLDKRIIADVQAATKTSK
TLRTASEVMVGLTALLFLFVMVFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFTQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENFADVMNVAELFAP
NIAPGVSGRLYILEREPWQMRCTAEWLSPEGDKKPFHPDECWAVRRGQSHPPVNGEPDIG
CYHLPESQAQQSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQMKQAVRNEEPVSCLMIDIDHFKSINDRFGHEA
GDLVIKSVAAIIQRAVHDSGLAFRYGGEEFLVLLTGADEEAAHGAATEIYNGVHALSLRY
GLSEIGPVDVSIGIASYPQHAQSDNLLRAADVALYRAKELGRSRIVSFGMLEAG
>A0A5I7Z0I2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Brandenburg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0P8IF16|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVTMFRCVVSLDVTQPDIMGENSHCVCRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFERQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
ADGEIAITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A6A8EJI3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A486D3X4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1J9ZP08|diguanylate cyclase|EC 2.7.7.65|Bacillus paranthracis|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCTHQQTIENIHPKCMFIANSFEEGEVLFQR
TKPHIVIMYVTDFSQIKYIKNMYNPQSTFIVIWDQQITSEFAEVLTLGIRNIVIAPVTPQ
MVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFRNDLLFIVEDDEIVDCNTNFLEFFGYEN
LFAYREQHLVFAEHLIRENGYYSTTHDITWLDDTLSYDRRIKMSNYEGEVSTFLLRATPL
PEDLSRFIVKCTEITELDEIYQEQERLAMIDSLTEIYNRLKFQQILEAEWDNAMRNNENI
ALILFDIDNFKAVNDTYGHDFGDLALIELAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFSGISKLTASFGVALYEKGITREELMQRADIALYEAKKNGKN
QVCVYRKEKK
>A0A2X1NJ21|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDSDSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A0K4N659|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A1M2U2A2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLSQKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHS
>A0A1V3VU52|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVYDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0D6IRG2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A8G8SPD0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLKNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5H9DQY7|diguanylate cyclase|EC 2.7.7.65|Salmonella muenster|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0R9MHN7|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2U9KQJ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A152X7V4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0C2AV70|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8H2C8K7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A838AX45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGSLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFIRNVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHEHNNATEPQVTV
SVPVDNNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPDHPGED
LFDPRELASLAQDIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRMYNRGALFEKARPLA
KLCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEE
FCVILPGANLEQAKEVAERIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377N110|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCAYIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIFFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A7B5V7K1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRAPANRELNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALLLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3W4D9P3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAISH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>C3TMI7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVNLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A1X9TDL0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITTMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A0L6XUV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLERRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3P5DPS0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLMRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRWMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A251ZKK0|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MKLSNDTPGYASSLHHLLTFTTLVVSLVCFAMFFSRIEKMNADMENILSVSILKSEFLTH
INDAMYLHDNLDATYQKNITSLYTGYVKHVFAADISSALKYEEEHFAENIYLKARDRDIH
TLYDDIGVNNNQFPQLARSAMKQTREVYSRQLLILILIPTIMALLRSIQSVYYFYSLRRL
RGNYMIDPLTGVYNRRYLSQLHDTQEVCYILAIDIDNFKTINDSWGHGFGDRVLQECTRQ
MTSHLRESDFVVRMGGDEFSIFLFKTDRTGALRASRRLLEMINGLQIPLPDDGSFTPSIS
MGLARCDGNVELALHQADLNLYASKKKGKNTLTTEGE
>A0A1V2FXI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7B5TI79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRLIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRVSAPF
NIH
>A0A792SZP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWLDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFGAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A265AYU9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEIAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A165JD54|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MSLELLQAAALNLKKAVPLMLKHKIPTTPVNYALWYTYVGEQNPELNQRLDTVIAQYNTC
PPVSSELLYRQYVADPVELDVREMRQNLDAMVTELSQSLKDTNLDANEFQSRIESNFEKL
NRIEDEGFSVEQVLDLVRSLVKESDNIRSSTEFFTGQLQKAQTEIDALKKKLEQTEKDVL
YDALTGCFNRRAFDSDFAGMLAQAPLGTCLILADIDHFKVFNDTYGHQLGDQVLRAVAKR
LQESCRDGAKLYRFGGEEFVIIVPKSQLRIARQLAEAMRRGLEKLSLKDRRKDERINNIS
ASFGVAQWQEKQTGMQLIEAADKLLYDAKRLGRNRVLPISN
>A0A1V3CY12|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia|TrEMBL
MIKPDKPANEALRLQALYRYRILDSQREKSFDDLVAIAKAVCGTSMAAVTLIDVERQWFK
SIQGIDAAENLRSESMCGHAILQPHQIMVVEDALQDIRFHDNPVVTGDPHIRFYAGAPLI
SSDGLPLGTLCVFDAQPQHLPSDKAEALAALSRQVMLVMELRRFALDIQKHMLERDDYER
LLSEYQDVLLAQNADLAEQSRTDALTGLPNRRAMAAALEEAVAEIDGQPGVACVALLDID
HFKHINDFQGHATGDRVLAELGVLLRSHFAGRGMAARYGGEEFVAVMPGTDLRTAELQCE
FLRLAVADLPLGFPVTISIGVAQHQPGESVDEMLARADKALYRAKGNGRNRVELAG
>A0A380TCW4|diguanylate cyclase|EC 2.7.7.65|metagenome|TrEMBL
MTSVVIVDDQAVNLKILCRFAQSLESGIDVKAFGDPAQALTAVGQGNIDLIVSDYVMPGL
NGAEFIRRCRQLTRDDELPIIVVTAFEDREYRYRALEAGASDFLLSPVDGQEFCTRARNL
LSLWRHRQMLRQRANTLESELASALRQHAEEIRLREEHLRRVVNTVPALIRSCDPAGRMV
LINSCHQKYFDLDGGADRGATREALLGEDYARKDRQLDDEVLKTGAMVVGIEETVHDRNG
RERVLLTTKAPLRLGEGDIGEIVTVSLDITNRKRVERQVRESENRFRSLVEGSVLGIVIE
QGDAPVFANSTAARIFGYLEPDGILALKSFESLFAPNEGRRIRRLKRSGVWSHTPAEPRE
FQGLRKDEGSLIWVELLTQEVRWRGAPAYLSTVADISLRKAYEERLHRQANIDEVTALPN
RTLALDRLRRAVGGAVRHRHKGGVLFIDLDHFKKVNDTWGHAIGDELLRLAAGRLRECVR
AEDTVARLGGDEFIIILPDIPDASHAAPVIRKILTAFSEPFVLDRHQVFVTSSIGVAIFP
DDSDEPASLIQNADAAMYLAKQKGRNTFHYFTPQVNEHAIERMRIEGQLVHAVSRNEFVL
HYQPIIDISSGLLSGAEALLRWHNTELGALDPEVFVPVAEDTGLIVPIGQWVLDQACKEL
RRFHNTGLPHLCVSVNVSLRQLRGVELIGTVADVLKRHGTPAARIELEITEGCLMHDITQ
VGRQLQALHGLGVRLGLDDFGTGFSCLSHLKMLPVDTAKIDKSFIKNASDNPGDASIVEA
IIAMAHSLGIRVVAEGVENGAQLSFLAQRHCDCVQGNYFSVPLPADEFIAWARAWSPRVS
APAAPSGRADTSLSDCPAASSGS
>A0A2T9I5G5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agona|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A4Y6N6Y6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Indiana|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A748EHB3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A625Z619|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQEQADRNMYQAKHRRAERSLN
>A0A1R2FSB2|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A485ASP8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MARHNRKLSFTTPILVGFAGILLSFLLIAAFVIATQKKNFLEDYHHVNRNFTHNLAINYT
ESLLRENDFILSRATTFFSRNDELNSAVNLDPQKGLRELMQLQELMQTVSSISLADTQAH
YLRAPEVLETEDSRTFDPESRPWFIKQAEASTFSLYTSPYLDYFTHRPTVTLYRPVISPE
GRLKGSLAFHMDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSSRLMD
DMTSAEGQLYDTASDSWYYYYSFTNPDWFVIYRVDNSTLIDLTRYETDIVAWGFALGAIV
IILFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRSVAREGLQI
LQPLQISLYRYGGEEFAVVFTAEHLTHAHTLLESWRIKIAQRTWREEGLSVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRIVRT
>A0A748I505|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5V5ABM7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3T2WCH6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Orion|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1S1A1P0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V4BFM5|diguanylate cyclase|EC 2.7.7.65|Salmonella virchow|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F6QM51|diguanylate cyclase|EC 2.7.7.65|Acinetobacter junii|TrEMBL
MISNLYQSTSLHALFRKSQFTIFAITFVICSCTFATISMFTMETYAKQNLQLLSQTVIER
IQPAVVFKDKGAIDQILKDYTTEHSIRSIHVYDPQQQLLAESTKKIASTSFLQKMLDEWF
LHDPIKLMIFHHQKKVGELVLYGSSENIVHFLKTIIIGLAISMFFIVIALLWSVNLTYRQ
IMQAIKPLTHIAQLVSDQKAYNLRFPNNHIKEFQNLNNVFNELLEEIQIWNTNLQKENRQ
LSFKAHHDQLTTLPNRHFFYEELLNIFENANYRENSALIFIDNNKFKVINDRYGHLAGDA
VLREMALRLKQSVRQEDFIARLGGDEFAIILHSIHHADHLEAIAEGLLASCKEPLDFNGE
IIHFGFSLGIAFSQYAENPEDLVMQADQAMYKAKNLIPHWFLYKPEI
>A0A853SD22|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MRLLSIKYRLLILLTLILGAGFMATSLASYLASRQTIEHGIADQTLPLTGDNIYSEIQKD
MLRPVFISSLMAHDTFVRDWILAGENKPEQIVRYLAEVKKKYGAITSFLVSDKSSKYYYA
EGTLKSVSPQATRDIWYYRVRAMENSDYETNVDVDMANRDSMTIFINHRVLDYDGRFIGA
TGIGLTLDTMSHIIDRYQARFHRNIYFVDGAGTLVLAGKTMRNGHGNIRSLPGVNAIADQ
IINHQSEPTHLSYQLGRAQILVNSRFIPELGWYLVVEQNVSDEVQSLQRVFILNLAISFG
VTLLVLVLTLLTVNRYQRRIERIASTDALTGLLNRQSLELLFQRAMLLSRRNEQPMSAIL
FDIDFFKRVNDTHGHLWGDKVIRGVADVARATVRESDVITRWGGEEYLVLLNNCNLVKAE
EVAENLRAAIEGHDFGLPEPQVPVTISLGVAEYRPEESESAFFSRADSALYQAKQHGRNG
VHAA
>A0A8G1MFT1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MATRNSAPLASYIDLLLDAVCAVDKQGRFVFVSAACERIFGYTPDELIGQPMIDMVHPAD
RQRTLDAAREIMGGDPKLNFENRYLRKDGAVVHILWSARWSEVDQLRIAVARDITERKQA
ESRQAALYAISEAAHAAEDLLALFKRIHLIIGEWLPAMNFSVALYDEHCAQLNFPYHVDD
HELQPEQPGTMTGRLCAEVIRSGQPILLTLDQDTLPEGFEASVSGQDSPCWLGVPLNSQN
GIIGALIVKSVPGGERYTEQDKELLQYVCAQVATAIERKQLHARLQRMAQYDQLTQLPNR
ALLRDRLQNSLAQARTDSGRMALLYVDLDRFKEVNDTHGHAVGDMLLQAVANRLKGCVRE
TDTVARIGGDEFVVLLHSIHAAEDADNVAGKIRQVLAQPLRLDGQSVNIRPSIGVAHYPE
HGTEEQQLFRHADEAMYAAKRHHHQRLGA
>A0A1C6HJW2|diguanylate cyclase|EC 2.7.7.65|uncultured Lachnospira sp|TrEMBL
MKDRRKSKKKRRGMLVLYLVVCTAVIVIAYFHLTKIAKDYNTEHLELISGLYAEKMNETI
DYLQSYAKENVKTVRNIEEREPEEILARLERDLDQTVFCDIGFFMKDGEIYGGACAVADL
KKNGLDKQVKKAEESFISEPYQSSKNGGMVMTVVAMAPDDDRIDALYVSVMIENLKKLGI
YELLQGKVSVHLLKADSENYITCISGKESTSGIWNNLLLQQKYFRYYNGYSYNDWMLDMR
MGVKEGRFTANVRGEDATISYRSISSMPGWYIIVQLANKKISNITQYFSAWGVVYGSILM
LFTILYMLTILLMEKKDKEIYKGLSDTDALTGLFNRRAFQAAVDETLLKRIAGVFIFIDV
DNFKDYNDKYGHANGDLCLKHFAATMKKCFPKDSILGRYGGDEFVVYIKNAVSDDAHRYM
DEFQREISHLMMSGGEHVTVSASAGGVAFIGEGEDFVSLCRSADNMLYDVKRNGKGTFKI
KGAKNM
>A0A381H477|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MKLHHKALRLFISASVIVLTSSFLAYELIASDRAMNAYMGYIIEKADSSFLYDKYQNQSI
AAHLMRTFTEPKAPPSDEQQYALCRGFETGRNTHGINLTTHNNPSLHGTLQTAEANCAIV
ADDAPLLFAFDQAVAANRNQKDYGKGLGTVEDKFHYYLDIKKRYVYFYNLIDSRQFFMHH
WSFLRKGTLGINRNDIDGQFTGRTVLSSIYQDDLTEKNVMSFLTPVYLHGKLKGIVMVDI
NQDNLKNIFYTQDRPLVWRYLDATLFDLNSEKKIIVHQSENNLFNYVNYVHDLPGGIRVT
LSLDILYFIVSSWKLFAFYLLVTATLLNMVRMHFRLYHNVNRENISDAMTGLYNRKILTP
QLEQRLQRLVNTGTSVTFIAIDLDRLKVINDTQGHQEGDRTITLLAKAIEASVRKTDYAI
RLGGDEFCVILIDSVVPATTLPERIANKLRIIAPDKVISFSAGLYHMQPEDTIQDAYKAS
DEQLYLNKQQNHARL
>A0A855WXR3|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNHLEGPQTDALIAGFKAERDKPEWKLPTGRDLAPEIQ
GVSDTFIGQSTLLERDDALLYSELNATLGLGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTASIPLDDK
GRWFGVLAMGFPIGAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTADGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>T0PFM6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MNSLLTLTLLQQIIDQLPMNIFCRDTDGRYLFANRTFVEQAGLQQTEELIGKTDIEMPWG
NIFREEDDRLLAEGNPLLYQQLHCNSGDSTRWMEIHKIPLYDEQGKPVALFGMVNEIGQR
KELEQTFRQQQLLQRRLLDAIPDPIRLEDHQGLLIDCNQAFLDFMGMAASEALGQRVAHR
LSTELPMGRGEYCLVDANGQGRHLEITRVDVPDDEGNSLGILTLSRDITGLRTTQAQLQQ
EQHYDSLTGLLKLSHFLQTSRHLGARKASLLLVDLQHFREINDRFGIRVADRLLSQVARR
LQQLAPPQSLVCRVAADDFAMLLPELSEPLADWSRRLQKELMVPYQIEEHRIQIPVFLGI
AHGRANDAERLLSHAEAALAQGKRQQQHCTLFDPELDAKLKRRQLIAAQLPLAIKSGQLT
AVYQPIISTRNNQLHGAELLCRWPHPELGMISPDEFIPLAEELGLIGQLGQRMLEQGCAQ
LARWQGAAPDLVLSINLSPLQFRDPDLCPQIFACIERHGLAPWQLELEITEGVLMENADE
IESNLANLIEAGFQLAIDDFGTGYCSLAYLPRLQVATLKLDRSFTQGLATNQATTAIVRS
VIGLGHELGIRITAEGVETPEQQAWLVQAGCDRLQGYLFSRPLPPDEFARNYQLPGS
>A0A4P0V9Y3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MMAEQDSLTGLVNRRYYELLAQRALEQGTPRGEGGALILVDVDDFKAYNDHYGHPAGDAA
LHRLGAVLRQGARRPMDIAARLGGEEFAVLLYDSEEGNTLAIAERLRQAVEALGIEHRRS
SAGPCLTISLGVAYSTSGMGLDALYREADRALYEAKDAGRNMVRVAFQQHDRLE
>T0PK20|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKQKILIVEDSMTIRRMLIQAIAQQTGLEIDAFDTLEGARHCQGDEYVVALVDLTLPDAP
SGEAVKVLLERGLPVVILTADISEDKREAWLEAGVLDYVMKDSRHSLQYAVGLVHRLYLN
QQIEVLVVDDSRTSRHRTMAQLRKQLLLVHEASHAREALATLEQHPAIRLVLVDYYMPEI
DGISLVRMLRERYSKQQLAIIGISVSDKRGLSARYLKQGANDFLNQPFEPEELQCRVSHN
LEALEQFNSIQESANRDYLTGLYNRRYWFNEGQKWFEEHQRQQTPLALCVLDVDHFKQVN
DHWGHAIGDQLLCHLTRLLTQFFPDAMIARFGGEEFALMVPHCTVPVLLKRLEGLRQQLR
QQPLSRETPLFVRASFGVINVGRVSMDEALSEADRLLYQAKNTGRDKIVSQGPSA
>A0A1V6GJN2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MWHIIPHDDHNQSLRIKRFLIACASYLMWILLIWYCSIQGMIRLGPKEILLVFAMVLVMN
LVLYAIFRTGLNRRLKDPSLTMVQMSLATAWIMIVAYNLNEARGIMLQLYLVVFIFGAFR
LNLRQFIMLSILAALSYGLVILSLLENHPETVNFKVELLYLVILTAVLFWFSFVGSYINT
LRKKLSRANSELNHAVEIIRQKAIRDDLTDVYTRGYLFQILAREKSLADREGLIFSVCIF
DLDDFKKVNDSFGHHVGDMVLKTLSGIIRDNIRQQDYIARYGGEEFVLVLAYPDMHDALA
CVERIRTLISEASFPGLPVDYPVTVSMGLTRYQPEETIDSLLIRADDALYRAKRSGKNAT
ACEPSSLLEPAA
>A0A6N3DMV4|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMHSALETPLDFAVLRKAEESYLAKRHDPIWSVEIHNRRTLPV
YGVADAFIDGDELLSRDTPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFITT
EPLKNSTQALALYSQATSDAWFTRQTQRNNPARGIVWQTVPGDESPREIPVITASIPLDF
QRFWLGVLAMDFSVQEMKAFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSAHEQ
EMLKRAFAGENQGGIRLVTRYISWEKIRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTLMLMISWFVIRRMVRNMSMLQTSLEWQAWHDALTRLLNRGALFERATAAARQSERLK
RPVAVIQLDLDYFKSVNDRYGHHAGDRVLTLVASTIASHIREGDFAGRVGGEEFCIVLPD
TRLKEATAIAERIRIRINSREILLGNSASLRITASFGVSCSEDSSDYSFENLQSVADHRL
YLAKQNGRNQVCADG
>A0A157SG62|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MDPILAQLSASLPNAKSLEDLTRPLLDMLGAVTGLESTYLTSIDLEKGEQHIRYARNTGE
MNIPEGLTVPWSDTLCRRALEEDRMYTDDVGSCWGDSGAARQLGIQTYVSAPVRSEDGAL
LGTLCGASARQQPLKPDAETVLRLFSNIVAGYIERERLLDSLKDANNQLHAYAMTDTLTG
LPNRRSLFESLQRLLAQGIDQRSSVLVGVIDLDGFKAINDNYGHQCGDQFLQQIAKTLSA
ALGPGDVLGRIGGDEFVVAGPGPTLAGSDSQPGRIIDNGSPQAAAKLMQDRIGAATIGRH
PLGERWLDYGGASVGIVAVEPTGLGADAAVRLADSLMYEIKRTRKRSIRER
>A0A157SCU0|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MHDSAPAQAQVPATLPARFVLATGSALLAAAILFLCCLVGIWSRPPGLLAALWPANAVML
GMMIRWPRMANPAGWLGGAAGYVLADLATGGALAMTLWLTLANIAGVFTGWTLFSRLEPD
EQRLQRPSSVMHLFGICAAAAAAASLTGAGITTAVYAQDTLTGLTYWFIGELANYIIMLP
VLLTWPGLRRVALLRRSADISALLGRGLPALALAASLMAAMAIGGPGAIFFPIPALLWCA
LTYKMFAVSLLTMGSVIWAQLYSSRDMMGEVMASFIHATTSIRLGITLLALAPLTVASIN
AARNRLLAELEYAAHHDSLSGALTRAAFIKRGTQIWQGRAPSRCSAAALMLCVDGFRQVD
DQYGYWAGDRILQAFARQVRAVVREEDIFGRLGDEEFGLLLFGISRQECLGVGERLRAAV
ENMEIVLDDGSRLSATITVGITWIPDLNDTALGRLLVRADAALHRAKKAGRNRVVDDEDI
SLLRV
>K8ARW1|diguanylate cyclase|EC 2.7.7.65|Cronobacter dublinensis 1210|TrEMBL
MPDKILISRWRTKNPIRVVNLCFCAVFIFSTLLTWREVVILQDAWISSQRNQLDTIATSM
DRNLQYSVDKLQFYRAGMRYTMHNLLEGPETDATIAAFQAHRHAPAWALPAVRDHALVIK
GVSDEFVAESTLLERDDILLHNELNATLALGHMLSIADSGNDRPEMRTYYVSRAGFYLTS
LPFYGHGRIPEQYYEQVSSRWFLGHALRLNPARGVRWLHGRDPSMPSGQRVTASIPLDDD
GRWFGVLAMDFPISAMRDFLKNALSNDEAGGEIMLFDGQLSPITTTSSDIDSTLHFTPQE
KATLARQMELANHGDMRMDTRFITWAKLDYFDGVLVKVTTFSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARLAAKECEAQ
QQPFSVIQLDLDHFKSINDRFGHQAGDKVLTWAAGMLSRTLRAEDIAGRVGGEEFCIILP
GTPPEGARLVAERIRQRINSQEILVRPDTTIRISVSVGVSEAMRDGDYDFEHLQSIADHR
LYQAKQRGRNQVCDEG
>A0A1T4ZK73|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MVNLEQSEEQLEQEVEDLRYQLEIAKETLRAIGNGEVDALVIAGLEGEQVYTLQGADSSY
RMLVEEMKEGAATITTDSTLLLYCNKRLASLVKTPLKNLIGTDFKEFISPSDLTLFQALC
QKASLGSGKAELTLIARDGTEVPVYLSINILNQKGVEVGCLIITDLSEQKRDEDIVAQER
LTRLLLEQAAESIIVCDYQGKIIRASQEAQRILGANLLLSDFDDLIKLELLPPQNGSPAL
RKKEKSSNSIFSIASVINGHPYKGREVLFIRKDGEKINFLLSASPLSTPHSVFKGCVVIL
TNITERKWSEESLKKINEELEIKVSERTAELESLNSRLKQELAEQARTQQILQDQAQLLD
LANDGIIAIDLNDHINYWNQGAEKLYGYSKSEVLGKNLVKLLKIQSPESLEKIKQEVLKK
GNWEGELIQIDREGNTVIIHSSWSLKKDSQGDPIAILKINRDITKAKQAEQAIIDSGLRL
AGILDMAQDAIISINEQQEITLFNQGAEKIFGYTANEILKQPFNLLISEFLFHNDCQYSP
ELLPDHCLIKHIGEYQEVTGRRKDGTEFPAEVSISQLSLEAGKILTVFMRDISDRKRVEI
AIQKAQEDLEIKVQERTMQLATSNDELIREIAERKLLENQLHEINEELEQRVKQRTNELA
KAIDDLKQEAIERQKTTLALQESEARFRAAIDGSLDAFFLLQSYRDAEEKLTNFVLVDMN
SKAEELLSQNKDNLLGKGLNEVFLREENLTYFERCLRAFRTRKGFEEELEISHPNIKAKW
VQMQVVPLSDGIAITCRDITERKQTEEAAQQANKNLTRWVNDLEQRNRETLLLGQMSEFL
QACNSTEEAYQVINDLLKPFFPHISGGLFVARNSKNLVEMVAIWGDLNGISEAVFSPQDC
WALRRGRSHFVPASTSNLLCKHIHQKNYRQYQLNSNSSSKIILNSSTKTEPPSPYPVMVE
HLCVPMIAQGDALGLLCLASEESGQISGDQQRLATAVAEHIALALANLKLREALEYQSIR
DGLTGLYNRRYLEESLEREINRAQRQKFSLGIIMIDIDHFKQYNDTFGHDAGDIVLQQLG
NILQKNVRGSDIACRYGGEEFTLILPEISLELVKERAEQIRVEVQQLKPKHRDQDLGQIT
LSLGISMFPSQGLTGESVVRAADTALYQAKEEGRNRVCVFGTNFDHSA
>A0A1V6KG07|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin002|TrEMBL
MAGWIRNARLGMFLNLCIGGFFILAAVVVVVSVNYNMREQALVEAQSKARIILDRNLATH
TYFSRIMKPSIFAWSEPFRSKDYFDHTWMSSTYALREIEKFFKALNPSGYSFKDSAVDAR
SPENEADEYEKVFFENIKAGRQPETESKVRNIGGKPYLVVLRKGEVMEASCLRCHSRPEN
APKGLTDYYGSERSFNRREGELASIVSLRIPLAEAYAAANMFSLKLSAILLLVLICLFGI
QFWLYRRYLLAPLEIIREKANKIATQEGHLGEELPQPFGREIGELTATFNEMSVKLRHDR
DHLEELVQKRTESLRESEKRYHSLFENMLEGFAYCRMIYDSDGHPADFIYLDVNSAFERL
TGLADVTGKKVTEAIPGVKELTPELFEIYGRVALTGNPEKFEIDFKPLGKQLSISVYSPE
KGYFVAVFDDVTERKLYEDKLKHFAVHDQLTGLLNRRGLEENLSRTIAKAKRGGVSSLLY
TDLDNFKDVNDTIGHSAGDEVLMILADLLKAALRTEDIVFRLGGDEFAVLLDGIDGGDAL
LAAERLRAAVEAHRFELEGRVFPLSLSIGLVKIDGTLALGELLSQADTAMYRAKAQGKNR
VVAT
>A0A173RXH6|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MDKQNFYQEKYEYYRTLNLWAVFGISIPSIGYFFSDCYLLGGFSTETLISRSAIIIPFLI
YLILNKYTKDYRIMVPMSYAIGHGVMWCTIWACTYLDDLSFACVGFFIILFIFMAFGIAA
PLPYEVIGHGLLFVDIAIANTFLHYPDYVMMFLLGIPLYIGICVFDVAMEKTYRDQVALK
LKLEDHLRHDALTGAYNRNVFESLVGENHTFICAKGEYMAIAMYDLDKFKRINDMYGHSA
GDEALVAVSEAVRSRLCEDEILVRWGGEEFIVIMKQNERRFEEHAQEIREAVEQLQLETG
TVTISVGVAECREENYQETIKHADTALYRAKNMGRNRVVMYCSEMDSADNGYCG
>A0A839EUH9|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium myrsinacearum|TrEMBL
MTARILVVDDVPANVKLLEARLSAEYYEVVTASNGYEALEFCENNSVDVILLDIMMPGMD
GFEVCRRLKSQPDTAHIPIILVTALDQDMDRITGLNFGADDFLTKPVNDLQLLARVKSLV
RLKNLTDELRLRVATTRDVGLESILRFPSGIEAIGRDAKVLLIDERPASVERIRTVLADE
CTVDVQTDPQTGFFDAIQGNHDCLIIASSFTDYDPLRICAQLRSLDNTRSMPIIFVADQG
EEPKIRRALELGVNDYVVRPLNSNELLARLRTQLRRKAYHDGLRASVVKTYEMAVTDSLT
GLHNRLYLETHLATLFKRAVDRRRPLSILMTDIDRFKLINDTHGHDGGDEVLREFARRLR
RNVRGSDLASRYGGEEFFIVMPDTDLTMAAIVAERIRREVASTPFFVDDGITSVPVTISI
GIASVQSKDDTVQNMLKRADEALYGAKASGRNKVVSEAA
>A0A7H4P2M7|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MRANIKSLPQRIFLYAAVCILAITTLNYLSDSLIHRIPTTSSMLFPVLTISLMTFHIMIA
CFMGMKYLCDKKRLYLVPITFAFACSAMLMLGTIGSYPDWLICGQGRAINQNDALIFYFF
RNVMMAILFITSIVLYRFRNITLSSGKIHRTVLTGCFVFIAAVLILSWIHSSNSPLLSVE
FLDNLTYTFTPLWHNRIGWLLIIIWSVTLILLISLTQLRNIFWYSGAFFCTAYIFTLMVL
LSTAGDSSHAWNQARFFETLSTLFLILVLLCDVFMLYRESNERYVRSYQNSIRDPLTRLY
NRSYFYDTLNQRLPKVSASQPLSVIVCDLDRFKRINDTYGHVQGDKVIQFAASVLQNNVR
QDDAAARIGGEEFALLLVNIGAKEALAVAERIRLSVSEKQEGLPERMTISMGVFTTQDTR
VSAEECVKRADTAMYEAKNSGRNRVVVWHE
>A0A8F9TGC7|diguanylate cyclase|EC 2.7.7.65|Pseudochrobactrum sp. Wa41.01b-1|TrEMBL
MPSQLQKEIKRLKQELAEKEKLIKEQAQTFSHYKKIYGQSSIVAQIGIWECALPTEELTW
SDYTYDLFELPRGTRLDRSHTLACYTEVSRAELVKRRSDAIAARSGFTLEAEIITFGGKS
RWIRITASIECQNDIPVRIFGMKQDITDQKLSFDHMMYLAEYDQMTGLANKSQFLVKLSS
AIQGDQVASGHGYLLLIDLDGFKPINDEYGHIAGDECLKEISNRLKSINHSYKEIFRIGG
DEFAIITSEIQDIKAVQKFAQRIIDCLSEPFIFEKQFLKLGASIGIARVAGDSAQDVFVN
ADTALYAAKAAGKATYRCYNPNMGNCAVRISV
>A0A0M7DFI5|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MHVDLLTLYFITIGTLLASAGLTFWEHRTHPNRSRSLGILAAGFGTLAVGCICALFRADM
PAAIGAPLSNLVILSGYLLVLNSVASLSGRHYRKRSVGLLAVMALIWLAAGVPGQDVVWK
YVSAFPIALVSALTAWELLRCDSMKTLKTRNFAIAVAGIHALIYFCRTFLLPWWVAVEGP
SVQLLASNITMYEGVLYSVLLPMTLIKLIREETHAQLVRESQTDYLTRLGNRRWFFEQGA
RLIAASAGREPIAVLAFDLDQFKAINDRYGHHTGDLVLAAFATVARDALGPQVILARLGG
EEFAALLAGDDARRAHQLGAAAARRFATTIANPADGLGIAATVSIGLACFDEDVPPLADA
LARADLALYRAKSLGGNRLEEVLAPERAAAD
>A0A3S4S302|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MPHGVDAQPSARRWHAVGLTAYLAMLILYAAAAWHSGVDAGGRVFWVLGGAAIVACVAAS
IGRWCGWQQRRELLIAWAVASLSVTTVVGLVAPTVTSALPGTITITFAYAGLTCRRGRSL
ALVPLGIVAFVVGGAKDLPDALPTVVVTAIMWVLVAEVPAWLISRLEAQSVLLRTVAETD
ALTRLLNRTTLPRRLSEHASTSAVVLIDLDGFKPFNDRHGHAAGDQLLVAFADVLRGAVG
VNDLVFRIGGDEFLLILVGADRGAAEQLLDAIRMRWSEAGEPVGFSVGIATGDNDAMRIA
DHWMYVDKRSRRLPGQ
>A0A602ULV0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F7U0Z2|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MEQVFYWLLDTSHGHGFGLVVILFCVIMSFVLYSRLQKHIEALVQDTPTALILVEAQSGK
LLLANKGAMQLLAIRRVGKSYLLPDTVPCQFLLSIINQFSGEGFKRFPIEWRVSKNTRVK
VEMSGRRTIYRRRVSWLLYLSSYQATEDEMAREIESLSVVRSALDNLSELVFIKNNEGEL
ISTNRAFERFWGVRAEEGSEDIKGVVKGRANKRRWTTNADGRSCLLETYQNILISSSGET
MGSIGISHDVTDWHNMQQNLRNEMDKRRDTEVALAQRDTILQNILESSPDSIGIFNENMV
YQACNKPFVRALGISDVDDLIGKRLQDVIPDDVYSRLSETDQKVLYEGKSLRYIDKAINS
NGEFTWYDVVKSPFRDPASGTNGVLVMARDVSDRYLAAQKLEEANQELERLSFIDSLTQI
PNRRRFDEQLATLWPLHIRERQPLSVMLCDIDYFKGFNDYYGHQTGDEALAKVAGVFKSV
LFRTSDCVARYGGEEFGFILPNTTVDGALQVAEKIHQEVKLLHLEHCASEASSILTVSIG
IATLSPQPMDNSESLIALADSALYQAKANGRNQTCVHHTSDN
>A0A1E3GV21|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MSKTSEQSLTAPISAAEVNDLLAARILIGGTRLSDLAFLQTMLSLSGFTNITTANGPEKL
MQVLRQTITDDHCDIDLIILDCRLGDCNARELRLKLDQFDEWRLIPVIALTEKSQWNHNQ
LLTDLGHGVTSLLYRPLTAEALPPAVMTTLAIKRERDHYHLRQQQIEDENAQLRVMEARL
QFSVNHDDLTGLANRRRLEQALDITLTQVRNFHTSSAVFYIDLDSFKVLNDAEGHEAGDT
LLVQVANSLRGFFKVRDTLVRIGSDEFAVLVDTIDPETAVARAEGLRDLFDGYSFTFHDH
EYHLSASIGVKCITEANLSTVGEILSHANQACYTAKKRGRNRVHVYSPADREMYALRHSV
EWAPRIRAALKQENFILEFQPIYSLKENKINHYECLIRMRGQGDKLYYPQDFIPVAEAMG
LIHQIDLWVVSHAFELLRNIPGDIALAVNLSGNIFLDKNLYPLVERKLLETGVDPSRLVF
EITETSAISNFDQTKQMVDSCAI
>A0A398Q2S0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGFIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A2X2ISQ6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A518FHR3|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MNSPQIATSQTVPQQQQSVHGSYNMGSSQILRELIAFSAESDEIALETRHADEIDQVICR
KHLRKLLTALQARDAATLSHCRRVAFLAKGIATNLGWEGIHLKRLEVAALLHDIGKIGVP
DHIIFKPGKLTSDEIELMSHYHHIGLDVLQACRTDHEVLTILSQTRFHFSGATNGYQCIG
SDVHQGARILAIADAYDSLATDQVYRAGKKHEEIMSILMGAAGTQFDGNIICALSRWEQT
ERDTFHEAIQEVNQNFQPKPLTEQEISEANLISNIFSYLFQIESLYDGFYIVNADFQFVL
FSPGLEQLTEIRAFDILETAWTNHSLPITNQEGTSLASSEHTMNRVIASGKSMTTELMLK
RPDGRLIQIEVQSVPMFGEDGRLVGVAEIFRDLSRSLKRPQEFNELKMAASQDALTSVAN
RGELETQLAILLNQASQNQNAAPLSIIFIDADHFKNINDTYGHAVGDEVLIELARLFQHE
TYSGELVGRYGGEEFVILCPETDLDHARLKAERLRLAVNNLKLSNLNNNRITASFGVAQL
EPGDSLESLFHRADNALYQAKETGRNRVCSLTCDEQMSGAAPDIVEPAQPNVGKMVFESS
FSALISSDIVVYKLGGFVNDNDARLTEVNPNRAVMRLGKAGLLPFWGKTDDRRPIEVELV
FDNATKKSTSASRHATPRVEVMIRMTPLGWIKQPDVFQQRATRVFRLLKDYFVAD
>Q6R283|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFFDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQAKTLAKLANHAAKKWQRQTGGVVDLSNLXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQG
>A0A2S8DXA1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2Z2DBN7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPSYTTQWTEIPI
ASF
>A0A398Q6S7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLSLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLNSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLRQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A398TXF2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTTEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A852UPW7|diguanylate cyclase|EC 2.7.7.65|Sporosarcina sp. JAI121|TrEMBL
MNRKRFIYSLVFLFTVILVFIDTILTEEASGHYPFIWSLALIPIIYIINMYPKWKVIIGS
GVFYSFLKYTTEFSQKINPSNSEINALILGSLINWSIALTMGYFIIKSHKLFLKVEELTI
IDSLTGAYNRRYLELFMEKSIPISKRTNSSLVFMMVDIDHFKKVNDNYGHQCGDQALKHT
SSIINNNVRNTGVFVRFGGEEFAVILPNTDVAEGLIIAERIREAVEKSEFIYKSERIHFT
ISIGVSIYNGENVEEFIEKSDSALYKAKENGRNQIAIN
>A0A8E2P435|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A7U7B0F7|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MGDLLKKLSRLSVVAKMGLLGLAALTPIWLILDITQSARTRELVEREFAARLEVQAHEDR
LRFDVSLRAHHVLAQTIAASDYAHEHILDKHVRPYKTGVHPPVEMPAGIKVKTPSWFPRK
SVLRSFPPVYFALVLDPTGLVLDGYATSAIPFPDALALINLRQIAVALEDAQLRMFDGIP
YLFSASAILGDEGKTAAYVMLVSQIDDDFLLSGQGLFRDKNHILILAAGNPARVLASTEP
EIMPTGSLIDRLEERFLVTGEEFFDYGASEIRANFTTLIPKERMNLLVQPILSQERLQRT
SLALTLSLLFAATLTYLIWRLNRVSERVSHFSRQAFGTALEKERQEDELKGLEIQIERMT
DEVMKARSRLEREAEEKLKHMAFRMKAETEVERLRVLHDVTGHLGVGIIRLDEGGVVPEN
ATMQDMVRRFGDIARFIAHADDEGDIALEDETGGLHIFERLKLRGQGLASLVLVKDVTML
RRSQEEQKSMALFPTQNPFPVLRVHENGIVMQANDASLPFLAMLGAKQGGKLPAPWDARV
REVMADRQIRTHECQVDGQCLSLNLVPIPDTDYINIYGNDITELHKAQRELKLAASVYES
THDGVVVTDGHGIILSVNAAFSEITGYAPEEAIGQTPRILKSDHHDEAFYADMWKSLQAE
GRWQDEVWNRKKSGELFIVWQTITAVRDESGKALRFVAVFSDVTEARKKDERIKHQAYHD
ALTGLPNRLLLQDRLAHALDLARRDVVRVAVMFLDLDRFKVINDSLGHDIGDMLLQGVSE
RLLLCVRKSDTVARLGGDEFVIILTDFGSTAELAHLAERIVSLVTERFELGGQSLHAGTS
IGIAVFPQDGIDATELLKNADTAMYQAKAGGRNTYRFFDTSMNSRATERLEMESGLRQAL
EMGEFEVFYQPKVRLSSTEPSGVEALIRWNHPAHGLVSPAEFIPLAEDTGLILPIGAWVL
ETACRQVKQWLDKDLPVDHVSVNLSCRQFQDLKLLERIKDILTRTGLDPARLELEITEST
VMSNAAQAAQVLQELKEMGVRLAVDDFGTGYSSLSYLKRLPIDVLKIDRGFITDLGSNSE
DLAIVEAIVNLGQTLELTTVAEGVESQVEADLLRKLGCDMAQGYLYSKPLSAERARQWLR
MTVERMSAPVEM
>A0A350GKE6|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A8B2UL03|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. 9-2|TrEMBL
MQRDTFVVRRSFLQWLQKRSNPGLIVNSCFLVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVANSLDRQLQFGVDKALFFRNSMRDALHKPLAFDVLHDAVVRFDTLRKQSAWQLAVDK
ERTLPINGVSDAFVEKTTLLNRDDERIRNEISAALEVGYLLRLASSAAQNEERVIYISRA
GFYLSTDTPAQSGDIITRYYHLVTQPWFTQQSERNNRARAVRWFISTASSWTGNERMITA
SIPIYFEHYWYGVVAMDFSFSTMQRLLADATDDHAEGEYQLYDSRLNIIASSESPASLMN
HFDEREMAQIAHAIESDTEGGIRLGSRFISWERLDHFDGVVLRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQNSLQWQAWHDPLTRLNNRGALFERARILA
QQCQQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGIIASGLRENDVAGRVGGEE
FCVVLPGVALPEASMIAERIRARIDSKEILVKKSTTVHISASFGVSCAHEKGNYNFEQLQ
SIADSRLYLAKQGGRNQVIWRDRDKK
>A0A3D2T2Y9|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMINI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A2X1RIV2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MGFASLLINFSNIVFIVTLAQLVLWDKRRADSMPGPINALNLFCFCLLAALLCAAVGALG
SVDVERATFVPQLADWFSEQFSMAVLILPFILTLTLPSALSGFRFRQLLPVLALVLSIAL
GVAVGGAGSITFPLPALIWCAVRYPLPLTCLLTFLTGIGEILLVANSLIHFSPDARMQPW
QLFSTRLGIAAMLISPVIVASSVEAINTLVKQLALRADFDFQTRVYSRSGLSEALKRQTL
PADKLLTVMVLDIDGFKRVNDALGHEGGDCVLTQFAQQVRQLVGEQGMVARIGGEEFAVA
AVVDSAQQGYLLAEKIRHGVESQPFGLGQNPIHLTISLGLETREVGHARITELFNQLLLA
ADDEMVKAKQSGRNQICMPTLTESAP
>A0A377V3D4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAAL
RAADEAMYQDKKSRRQENFIHID
>A0A378F810|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MWIAGGTFDVMDEIVVQPRWMGYYCEDLLRLSGMLLTVVGVYKIIERINLLYVDARSQSL
KDELTQLPNRRFFIDTIREKSGHALGLMILDIDFFKKINDSWGHLVGDEVLFSLGKQLAK
LTSEQVQPARIGGEEFAIIVDGLSEPELHALAQAILANARTILINHQTPLSISTGVGTWR
PGEAQETFIRKVDEALYKAKHNGRGRVEWAPSAGAAG
>D4E7T7|diguanylate cyclase|EC 2.7.7.65|Serratia odorifera DSM 4582|TrEMBL
MIFDKLLPSQLNMKNPQKVVNLSFMLMVLIFIVLSWREAIIINESYTESQRNKLLSVATT
LDNRIQYSLDQLNFYQSIMVQALETPLVTDKTRAVQQRFDQIRQRTVWQVEVDLARGMPI
NGVSDAFRGQFPLLHRLPVGALHKELAAALEFSFILHLRDELKELQKRTYYISRSGFYVS
SAPPQNHKEQIVSWRRMMTHNYFTNGQPSRNPQRKLTWTEVYNGILNEGPTITASVPIDL
HAEWFGVIAMDFSTRDIHQYLSNSLPSQNDGTLLILDKKFNVIASTQPTAAAAALTPTER
RRLASALANDDFGTLRMGTRFITYSALKNLDGTLVNVHSLSEGMRGEYGRIISVLLIMWL
VFSCALLLAYQVILRLVRRMSDLQGNLAIRASYDTLTRLYNRGAFFEKAYAIVEKCRAIN
RPYSVIQIDLDHFKFVNDCYGHLTGDRTLATTARLVLGAVRQHDVVGRVGGEEFCVILPG
TTKSVASQIAERIRASLEGAMILTDDNLPIGVTASLGVACADEDGSTALNDLRMIADRRL
YTAKKNGRNQVISDDTPSTGA
>A0A377WN71|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLMEVASRL
MTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNLHNGHSATLSLSV
GYALAWEHATAESLQELADQNMYRMKKPTYPADAEIIKDSL
>A0A377XNJ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLVGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITKLIGQVDALITEWRTAGCWL
>A0A486VU79|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQAARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRSAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A5E3GVB0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A485RHV5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKWINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>D8G512|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MLCWNLREPNSTPVGEENSACQQEAILSAIFKHSSEGIFIVEPIQGEFHFVCANHIYLQM
YAIADIDVASKPIGECLPDAIARTTEQNLTICLQQQQSRSYQQPLETETGSQLVLIDLSP
IFVAGKITKILGICHDITERQRNRAVAHLLQTITLSVAEAQDFDSALTIALQKICQVTNW
NYAEAWVPSADPAFIECTPAYYSTSQNLDSFRSIRKQQKFSASSNLGQIWSLQPLKWMPP
DLPQPVDSLLDPDIAAIAGFQAGLSIPILASGKLIAVLVFFMFEPRLENKQISLLSAVGV
QLGVVIHHKKYRNIFENAVAGIYQTSAEGRYQTVNPMLARIYGYKSPDELMTGITDIGRQ
LYVNPNRRDEFKRLLQKQDVISGFESQVYRQDGTTIWISESARAIRDERGQIAGYEGTVE
DITKRKETEAELHKQETLLQGVATAMHHLLTDADHKAAIIKALGTLGVVTGVDRVYIYET
HPHPETEEAALSLRFEWVMASIEASINPPDRQNLTPNSFGLTQWQSILEATHAITDFIES
FPKEEREVLEGEGLLSRLILPIRVERQLWGYLGFDDGNDSHRRWSEGEISILMVIGESIG
GALQRQKMEETIRHEALHDRLTGLPNRTLLGEKLNLALQNAHRRGSLFALMFLDLDHFKI
VNDTLGHAIGDRLLQAVVKRLSSCLREGDTIARWGGDEFIILLPNISRAKDAAAIAQRIL
EVLQGEFDLEGNKVAIGSSIGIAIYPEDGDDSDILMKKADGALYRAKEEGRNNFRF
>D8G2H0|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MINTPIEKDSPLILVVDDEKSMRVLLRRAMEKQGYQVIEASDGEQCLEKCSKRWPDIILL
DAIMPIMDGFTCCSELQKLLAQEENAKEQQEQPNTSFLVPLSAPRERTPVLMITGLDDPE
SVDRAFTAGATDYVTKPIHWAVLRQRVRRLLQNGQLIKELQQQNEQERLMARMLERIRYS
LNLDVILNTTVAEVRQFLQTDRVLIYRFYPDTKGVMVVESVVFPWVSVLGTTLENYCFSE
DYAELYKQGRIHTIEDIYTADLSECHKNFLDRFQVRASMVVPIVIREQKNWGTLEIGKLG
DGENHTAPFPFAANLPQNSTTSPKSTLTSEPRLWGLLIAHHCSHPRRWQPAEIRFVERLA
AQGAIAIQQSQLYQRLEAANGELQRLASLDGLTGLANRRQFDEYLEYEWLRSLRNGGSIS
LILCDVDFFKLYNDTYGHQAGDECLKKVAEAINEARQQPGDFAARYGGEEFAVILPCAEK
QRALEVAEDIRRRIAVLQIPHATSKVSEFVSVSLGVANFVGKQWQPVSSVSREGLIAMAD
KALYQAKQEGRDRTVVQIC
>A0A8G1LXC0|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MREDPLSPPDLGAEINHLRFTLDHVGAYVFTKDLEGRYTFANEMVCDLFGQHLDDVIGFT
DEKFFDLTISDELRKNDLSVLKDGNHIEQVERNIIATTGEERIFWTVKRPICGADGKVTG
LCGISTDITERLQLERDLEEQKKQLSQVLENMDAYVYIKDREGRYLYANENLARLYSKPV
NEIVGTLEQDLLTPETSERLAAMDKAVFDGGCKVTGEEIVSDVNGKEIFCWSIKIPLFKD
GKADRLIGISTDITDIILLKNKYQNLARIDTLTGVLTRGFLIEQAESILLRTQRREARLA
VLLIDIDHFKAINDSYGHAFGDTYIISIVNACQKTLRESDIIGRFGGDEFIIVIDEADED
GLTIAAERFLASLRDSILTAPDGKKLKLSVSIGAALSDQSSTFEELMARADHALYQAKKA
GRGCWRTAPSANS
>A0A8G1Q0Q5|diguanylate cyclase|EC 2.7.7.65|Pantoea ananas|TrEMBL
MTYYSPDDHHLKMRSTRFVCRMFAMRQLGTLLCFLPIASVLLELGKEPAILVLLISNVLI
WPYLAYRLAVTSRDSTARERSNLTLDAAFGGIWIALMAVSPMPSFVIIAVLMADRYAAGG
WPQLLSAAQAFLFAFILVWTMEGAPVLMEFSTRTAWLTLPLATFYMLALSVVSHNLTLSL
RQKNRELERIALMDPGLEIPNRRLFERRLESELLRTLRGDTRAYLILIDVDHFKNVNDTF
GHEAGDFLLAEISGLLRNSVGMKDIPARFGGDELGVIIRDSNDVDIIRLAESLQSNIGQL
RLPASVTFRCSVSIGIASADKADSIHEWLRRADKALYEVKRSGRNGLKLWRA
>A0A8G1GNL8|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MPRIPKRIRLLLLVAILLIGGFLSTSIASYVVSRDALREGLISSALPLTGDNIYSEIQKD
MLRPVFISSQMAHDTFVRDWLLAGEQDPTQLSRFLREVKIKNGTFSSFLVSAKTMRYYHS
DGILKTVAEDDSRDAWYFRVAKMPQEFETNVDPDLANRDKMTIFINYKIFDYEGQFIGVT
GVGITLDTMRHLLQNYEARFQRRIYFVNQAGQVMLTGDDQQARTSILQQEGIGEVAHKIL
NHQTEPMAVTYSLNEQLVLLNTRFIPELGWYLIVEQNETADLRPVQTMFQFNLLISALVT
LLVLFIATYSINRSQSYLETLAKTDGLTRLLNRHAFEAVLTQKRSELTRRQRSVSGILID
IDFFKQVNDQFGHTAGDEVLRQVANLLRKTARSSDTVARWGGEEFVILLDDCSKAMALEL
AERLRKVVAHFDFSLPDSYQVTISLGVVELLQGETEVEFFQRADQLLYAAKSSGRNCVMA
DL
>A0A3M2RM16|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MSIQLDFRTLSLTLMLFSIVFGLGMFAYAREHAKFSGIKTIGAGYFLIGGGCVLLGLRHF
IHDFASVVISNLAIIMGVILIYRGLFRFLGISLRFERWLSPALLVLLAPVLYFYTFHAPD
VSMRIQAFSATFAIASFIGACGLLQQPETRSRSVARMLIAMFLTVAAFFIFRVIWSFYDI
PPDDFMNAGLLSSLAVLAGEFVVISSSFATIWMASDELQKELSEIARIDPLTGTYNRRAF
DEACEIEFSRSLRSGSAFTIIMCDLDHFKKVNDQYGHHIGDQVLRHFADILKDRVRQHDV
VARFGGEEFVLLLPNNNTEQGRLVAEQLRAKTAATQIALGRDINLAISASFGVAQYCIGD
SEWSAVLHRADNALYEAKKQGRNRVVVSASADQSLEADPAPVK
>Q32G02|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGRNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTALCVTVRKLSDIFIHSER
FKCNVFYHFMFEEKSYFLN
>A0A1C6K792|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MDMTGAGDRALLDVLCQTADAVWEIDLPRQTVQVWQELDERQKPCVQLPLEQALQRAESR
VSPVDRPRWRAVWTQIRDREDPATGGGAELHFLRGTAQCGGTVQWRRCAEGHVWLTARCR
APEADSRLEDEWLCHHFGAMPLPAGVVKVLFDREGQPADLLFCRVNLALCQLLGQKETRQ
LEHRPLLEVLPEADLLWLRMCHRANTTKRPQHSVRYSQLLHRYLEIWTYPLDGERCGCVL
QDVTREVEQEGQLKESWQRQALLLKNTTDAVFQYDLARRTLFMSEGAAQWCRPLPTVPDM
PWGLLERGMIQQAGAEALRQVIGHLEAGGESAGCDILARLAPDETFGWYNVTFWRYRDRN
SGSWQVMGSFKNIHQEVLRREQLERAAAQDPLTGVYNVATGRRLVKQQLKQHPGGNGRYN
ALFIIDLDDFKGINDSCGHHTGDAVLQEFVCALQRAFRSGDIVYRLGGDEFAAFIGDLQR
PYRVVDRVSRRLLNDLSREDRCGVPVRASIGVFIGGGPLTYEQYYKNADRALYVAKERGK
NRVVVVEDNLF
>A0A1V5UGW7|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin243|TrEMBL
MSRNSKNVLGRLKSVFNNLKRVEAGLSEVIYFTAPPGRISAAEAEVRAYFYPESIGTAFI
SLLNGINLKDALGRGECLVIKKPGRSRVHYVLYDAGGDFYALALDQPQEPPPFQTVALRT
ALTLCLGFYETEISASRDAMTGLFNHGYFQRELRSLLGACEAEFEAIRENDAPLGYNLEN
SNIGLILFDIDNFKNFNDTFGHRMGDIVIEKVAEAAADEVSKYAGDLTLARYGGEEFAVI
TRGLSAELAVDLAEAIRSAVEAIDTSALAKKAGISLKPGRVTISLGAAFYEAGGIFSAGA
AFSPVDVCASELIKKADLALYGSKHLGKNRVTLYDELPFKCASVIERKGDFILVNVGSAH
GVDYNDSFEVYDGVYNGSTDVVNGAASKKIGCYPRLLKGVIRVSKNYGVFDSTLMEKIAV
CEIDGESLPIAAGDICVPVDSGEREIYSGDVFLPREIFASRYACGPSLNADETLSGFRHL
IMIDFKSVIDAVKYSAPLKFGQAVSEVETLTLKSGLKYERLFRLSSDKTVMCFKDEIVPE
KVERFAAGANARLKAFAGEGAALRVSVLNTAALNKVPLCDGEILKYLRMAGFVNRYYKNA
SCIEEFDYQTCRRYGLFYYYRSRHAEALDIFARYETAFRQPPDFRFYQNAGVVALKTNKT
GLAIKYFMMAEKLDGASPIPKSNLALIYSTTGAYDKAARYYAQCLELEPQSALYNNNMAY
TLLTLGKNLKYALKCSKKAVENCSAAQLPEFLDTLGEIHMRLKNYGAAAAAYKKALCSAD
RPSAPEPYLKLARASLMAGEKLAAVKIIEMMKTSDEFACSASEIAEFEKIIDKY
>A0A6B8N5M7|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MPQISDLFKFGPFELHQRLDALSLSYGDSQAWQSSLTTESREEIKTAVYTQLLQHFEHSD
VVSQILGHFHIHQSLDAYLDTLLTQELEEGYIEELAQHILGIAKYEEVHEYYSIVSHVLH
RCIIDNLASRCRSLENFRSLELRLQLDLSILLQFLHTKSMEDSRRYAALMEVKDPLTDLY
NHNTFPNELEKMLARCKRHKTSVLVLDIHLEGLGAINRRLGYEAGDTLLQNFAFIAQELI
RQSDLIARGTRGNFYFVLEDTTNRDGKAICERLISAVDGSSELPITLQIGGASYSSDSDI
DGDELLGLVHEHMELARARSLINHRHEYSVHFDSKDNLIQLIKG
>A0A6B8MWJ9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MVVASESEKVIRRLYQITNDYQKGFDIQITQLIMMGLERFNLDIGILSRIDGELYTVLYC
VTSEGVELKPGDTFNYESTYCQITCSSFGPVSIEHMGESDEYAKHPAYEAFGLESYIGIP
IFVDDEVFGTLNFSSASPYPRKFKDIDVDALKLMASWIEVELIRRKQEERLRKLNSQLEY
QAYHDALTNVANRRCMFKTIHLDIERMKLASGKGSLAVIDIDNFKRVNDVYGHQIGDDVL
KKTAQQLQACLSERDFIARFGGEEFVVWLPERTELERRQLIEELHQSANEILLDGEPVTV
SIGVCEFDFGNESEIDNKKGALDQIILVADEALYQAKNQGRNRVVVRPLSEEPVTEMMSG
D
>A0A8G2ABA1|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MLNSEQSINIQTQSSRSGMNLFSALLIIIAVSALCIVISKPLGPWDVIFANAGLYIDLLA
LLFLVFMLWISAKVRMSYVAVNWVRYGLLLWIAGCTFDVMDEIFVQPKWMGYYCEDLLRL
SGMLLTTIGIYKIIERINVLYVDARSQSLKDELTQLPNRRFFIDTIREKQGHQLALMILD
IDFFKNINDTYGHLVGDEVLFALGKQLAKLTSDKILPARIGGEEFAIIVDGMPAEEVRNL
AQSILENVRSILINHDYPLSVSIGVGMREKGEAQDAFIKKVDEALYQAKHNGRGRVEWAT
S
>A0A7X1EJU4|diguanylate cyclase|EC 2.7.7.65|Citrobacter cronae|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKKQNVIATWRYDAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGDRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQAFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A1V5GNH8|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MKLSHVQKFSAAVNTVILLMVFGLMAFFHLCKVHFLTMFSIPTAMIYFIGYYLIYKEKLL
AYVWMVYCWLTFYMGVTTVCLGYGYGFHLYCFSMIPTIFVTEYISYKTNKKSVKALPVSI
VVALFYVICTGYVAFFGPIYHPDQKFAAFFWIFNAVTVFGFLIFYSRYLITSIISSQEKL
IEAAHVDRLTHLYNRHYMLERLEEVPADGRESFLAMSDIDNFKKINDTYGHNGGDEVLKT
VADKIKNICSSCIVARWGGEEFLILSAEPLPDGKDMLERLRKNIESESISFEGQEIRVTL
TIGMAVRKSGQSIDKWVQDADNKLYIGKNSGKNKVVI
>A0A379JT46|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSDDAQRWKDKYLSSLEQQEKLERRWESRLDLLRRGLVRSSLAAEGADKAVDQCMQEMRE
ILRRDDMDAALGNLIPRLEKAVLDSEQRRQQRAGEAAAALASLIEQLQRLRPPREVRKAL
KSLGKQLEDATTHQYLLPALLSQLSNLQGQALTVLQAPVQEQPGLLLRLFGSRGETSEST
AQAPGSVTEATGVAEELAVELTPTPTPTPTPTPTPTPTAVAVANEPPPSVSKVASVPARH
QVQDASPVLDSLPLPPGLVRQEQAGDSPFSLPSSEPGYSAVAPHIASSLRNLLDELELPA
RHLPQGEALRLRLEGNLNWYELVPVLDDLAVLVLAVTDSGQREFAGYLKQLNERLAAFIK
TLSEAHEGYSASVENARSFNQQLRDLVSDLQNSVQEAADLESLKQALEQRLEGLLQSVSS
HQRQRDSASDDVAERLQGLVKRVAEMEQEAQQFREHIEEQRQKSLLDPLTGLPNRAAWSE
RLDLEVARRQRYGGQLLLAVLDVDHFKRINDGYGHLAGDRVLKIIAGELSKRLRKTDFIA
RFGGEEFVLLIPATPLEGGVQLLETLRAAIEACPFHFKGEPVTITFSAGIAEFRNGEATE
VTFERADQALYRAKGAGRNRVEQAA
>I3X6S5|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MAPPLGAGILACRACSATWVGMDIEESAVSANGVRPSTSMQLQAQDPSIMAEVARLLAGR
TRDIRLKGELRRLFQERSWPRTAKVIRAWMTWVALLDVLTLGLNAILLPKVIVLSMLAPA
CILPPAALATAFVWRKPRAIGLQRASIIAGLFFILLSVALVGVSAGGEFHERHLSIMLFV
AITAIIIFSIPLTWTVTVAAMALGLYLFFQLLNPSLETGSAVAAALFFASGIIATVVARR
TMTILAQKGFLLELRDRSRVAELADANARLERLARTDPLTGIANRRWMMETLNHLWSAGM
DSRGCAMLMCDIDEFKKLNDHLGHAEGDRCLVKVAGIIQSSVKRDRDHVARYGGEEFLIV
LPGVDEGEAICMAERIRRSVEAASLPNPASRISPYVTLSIGVATQSSDEKIASPEQLQNQ
ADAALYLAKQAGRNRVVLHNPDRIRQ
>A0A379K1A6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MLKAVAQHLLDNLRSTDAVFRIGGEEFLLILPGADPREASERLQSICAQLATRDVATRGG
DQRVTLSAGLAHWPEQGQALDELLQAADAALYQAKRDGRNRVCWLLAGADLSHPSRQAAL
RGDSG
>A0A080LVG5|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MNDDELIRTLAEDHVIPMTGLLSLLMPASAGVGFGLKGLDGRYRLANREMERLLGQGPTR
LLGRSESDVLPTHLLAQLARCDQRILDGAPAAYEEVEIPVDGRISRCRWINLSVFDTDHK
LQSIASIVHETRPSPEIPSMQQTLDRLRQENQELQRTVVELEQVASTDKLTGAWNRRRLE
ECVRGEMDRLNRYEQPLSLLLVDIDHFKAINDQHGHSVGDQILQAVTSMLQSRLRGTDAL
ARWGGEEFVVVCPNTGRSTAALLAERLRGQIASAAFPLIGQLTVSIGAAECSPGDTWEEW
FQRADEALYRAKTGGRNQVQLAPEAVRPADTQGYVVANFVQLVWQSAYECGNELVDRGHR
QLFADANELLAAILGQYEERRLDLIVETLTTDVAQHFADEESVILAAGYPGAAEHAVLHR
ELVAQARRLLDDYRTGKQGVGDVFQFLAYDVVTRHMLGEDRKFFPYLRAHVAAPAGNREE
PSP
>A0A2H6FV92|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin10|TrEMBL
MKKIWWIYFLLLAPTLTEFLESGSLPDKPRDMITDVVMTIFMGIFILIIYRGRRRLILVS
ETDELTGLKNRHAFQKELASAVAKAHRLHITLSLAIIDIDQFKFINDSYGHHKGDQILAK
IGKLLKDSVRSQIDICYRVGGDEFAILLPAIDLSGTEGIDRRIEALRDRGSELLEPYRTG
LSVGVASLGDGESPDDLFKRADSRMYREKKAN
>A0A261S616|diguanylate cyclase|EC 2.7.7.65|Bordetella genomosp. 1|TrEMBL
MPKLSNELLAQRWKDTCSPYAETEVLLAKTLIDANTTVLADYFYSRMLTDPNAAFFLSDQ
LVRNKLHSSMQDWLRAVFAAAPSGQFDEAVAFQRRVGEVHARIEIPVHLVMRGARALIRR
MHELLAESRDVAVDVLIQTSKYINDVTLIAIEMMCHAYAVSHDRNARAEEGYRLLALSQN
VGAEKERQRAALLDWENQLMFGLSVGQQWRELPRLGKSEFGLWFTHKAAHAFDGSPEARD
ARIHIETIDARLEQAGATPEPAGQRIELLHAVRDTTKAIAFLIDELFEQASNLESGRDTL
THLLNRKYLHVVMSKEVAYARKTGAPLAVLVADVDHFKSINDEHGHDAGDLVLQQTASLI
SSYSRGGDYTFRLGGEEFLVVLVDAGASQAFNVAEALRRRVEDKAMVLPDGAHVRITLSV
GVAAHDGHPDYQRLLKRADRALYAAKDEGRNRSILADERHTPSDHDDSSWSRALNDPA
>A0A379K3F6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MKPAHWQVDLQQVQQLRLFHNVATSSLDQLLREFRACELEAGEVLLSPFNRNQHLYLLIE
GQLRVYLGSLDNQAVSTLEVGDCAGEISFIDNEHPSAYVVAERPSIVLRLHRESLVALFQ
QSPQMMQNLLELLCDRVRQGNRQILDSEQNANVDTLTGCFNRRWLEHVFERETTRCAFND
EPMSLLMLDVDHFKAYNDQHGHLAGDYALCLVAHTLSSQLRPKDSLIRFGGEEFVILLPE
IADEAARGIGERLRIGLEQIPPSIRRLACCPASPSPSAWRRCSTRTACKA
>A0A655SM92|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVAFSYPLPQTNALLGLDYRTVPQQWQSIKKAREIKQTFVSGPVDLVQGGRALVIREPIF
YDPPKDTRYWGVLSVVMDWDSLLSATSIYSFGEHFQVAIRGLDSRGSEGDVFFGEPRVFE
HAFAQENVYFPYGSWRIAVAEKQDLLQQLSWYTRNAVRLLGYSVLLVLMAGFGVIMRLYQ
VAEERALHDPLTHLPNRRYFIYTIEHYFENAKRSHSEGNFALLNIDIDRFKSINDSHGHS
AGDKVLVACAERIKSSLRVSDLVARIGGDEFLVLIPRIHREQDVLKVSDNILKRISETPI
VYDDKLIHVRVSIGYALYDQSFATPDEMFKLADERMYTAKRRQNPLYRF
>A0A7Z1D4U5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIRSTRISLGLFFNYFLSSTKIDPGQNYISLPSIKSSTHIALLFMASMGTQKLKAQGFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILNNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A822TLJ0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIQSTRISIGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQKLQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A7Z8BKW2|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLSKEKRAFTLSWLAALSVLLLLMCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVLTEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSIYRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A5W8MDE2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hofit|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7Y8YBT1|diguanylate cyclase|EC 2.7.7.65|Kalamiella piersonii|TrEMBL
MAVLPLSVRTLRPELRVHLLFLAVFLFSFFLTLRELYTLHANYEDRQRAALVDMQNGLES
QFQESIDGLIYYRRMFTYALSHPLDADHGRRALAEFHQLRRQPAWQLRLNMPRSMPINGV
GDSGLAQDNLLQRDPARLDGELLAALEFSFIMQFSDAEADFHSRFWYTSRAGFFISSRPP
QSLSAISASYATIVSRPWFRAISALASSQQLRWSGVYQGANDEGAMLTVSTPVFSDGYWY
GVLSMDFTRQRIARLLNSMRHSALQGSVVLLDKAQQPLAALNASDGKALSDGARQRLYAQ
MARQPQGALRLESQFISWRRLKNVDGYLLNQQTLAQGLRQDLGRAMLFMLAMWLLFILLL
LVTHQVIVRLVRRLSQLSARLEWRASYDGLTRLLNRSAFFERFEAETARCQQLNAPLSVI
QLDIDHFKSVNDTWGHQAGDQALMRVAAIIAQALRKEDLAGRVGGEEFCVVLPDTGLADA
QKVAERMRQRLAAKTILVNASRCFSVTLSAGVASSEEQGDYQATRLQAEADRRLYLAKSQ
GRNRVVADG
>A0A6P1Q3W9|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MIGNSLSDRNAGPAPARPTLRKSLQRIHLIIIIVSMTISGLSLSTLSLIALRNYAENNLE
LLASTLSFTVQPSVIKGDARTVHEALAEIGSRGSFSYGRVYNRQGELLAGWHASPRQRQN
GVERLIARWLFPAPVSVPIIHSGETIGRIWLIGDACNVIEYLYKTFAWLAASLMMTATLA
SLLSRRMHAGILQALQSITSVTHDVRQRRAFAQRVPAAEIAELDALSHDFNSLLQELEEW
QHSIRREHASLAHQASHDALSGLPNRIAFERALQRAFADSERRQRLALLFIDGDRFKEIN
DTWGHAAGDAIITATAQRLRVQVRKTDMVARLGGDEFAILLHDISGPDQIARVAQHLMNA
MKKPLILPDGQSILWSLSIGAALGKSARSAEGLLAQADAAMYHIKSLGGGWYLSPLGQSQ
PQAEPA
>D6IAI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli B185|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>U4EFM3|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo FTn2|TrEMBL
MKRKFLFTPFLALLAVAFTTALVTQSTHLLVKKSPLAEAAAEIKLNGTLAYLWFDEIMSG
DTAQSIQEVWYYLEIADWHVVALLEGGESITGSYQPVDDPQLRPQLVALREILEEFRREA
EANYRQLQSKRSAVHSLQRDEHFLKFASKADDIQRFIKSSYESGIESYTHTSVTLILAVI
VIAIYAIRLQHKHERSRDLLLTSLTDAKNAIEEKNVQLHNRAYFDPLTHLANRTLFLDRL
NQSILKAEHAKKSFALLFIDLDHFKDVNDQYGHQVGDHLLQKVAKRINQCIRTTDLSARF
SGDEFVVVLDHLQDIKTAIHIANKTASKLNHALSQPFQLKNHNVLISASIGIAIYPEDSV
TQDTLIRYADNAMYHAKGMGKNNFQFYSNELNRIAMSQKKTERALDVAIESDQFELYYLP
KWNLKTEEIEGVEALVRWTHPTLGLQYPDSFVPVAESTGQIRLLDLLVTQKALAQQKSWL
TEGVDLGVLGVNISARSLKHPEFFEQLKTLIMESGVPPQKLEIEITETVMVEHIEFAQTI
FSELKSLGVRVALDDFGTGFSSLSYLKDFDFQTLKIDRSFVVDYATNTTSMVLLKSIIQL
GKELGVSVIAEGIETAKQQQDLHDLGCLTGQGFYLTPPLPAHALVERLLNTPNHNIVPIE
AKT
>A0A5P9J5P2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MPAADFNMHEIHWLMDMFNTVDVGLVVLDRKYRVCIWNGFMENHSGLLPSAVKDKDLFDL
FPSIDEKWFRTKTESVFVLKNRSFTIWEQKPYIFRFKNYRPITGKANHMYQNATFIPLTS
TTGDVTHVCIIIYDVTDEAVNKIELEEANRMLEQISRTDGLTQLPNRSFWEESLQKEFKR
VSRSQGHDSLLMLDIDHFKNINDSHGHAAGDEALRHIANIISNTLRESDMAGRYGGEEFA
ITLYDTDAEGAKVFAERLRAQVESSQVVVDEEVIKMTISVGIAQYDSAFEQHEQWVAAAD
KALYKSKQEGRNRISIANNGA
>C0Q269|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi C (strain RKS4594)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8G2MYD0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter terrestris|TrEMBL
MNTESIAMLAEQWKSICDGYSTTDLNDTFQFIQAHSQTLVYEFYKNMMQEKEASYFLSDD
IVQSRLKATLNQWLIDCFQVPLHQNFEPIVQKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFVLQAAQDQENSLRMISYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAA
QKDKQRSSLLNWENELMFKVFSHEPKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVKAIVD
RIYQIDTLSQQVLNAAEKDESIRLIQDIREKNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNVPLSLLAIDADHFKRINDKFGHAAGDSALQFIGEALLDCI
KGSDYAFRVGGEEFLLLLVDSDLIRAQEIAEQIRSRIQETTIGTRPGSSFNFTVSIGCAL
YDGHPDYQRFIDAADTALYAAKNSGRNRVYLAKNELRNSNIDLTVQS
>A0A2T0BPS9|diguanylate cyclase|EC 2.7.7.65|Clostridium luticellarii|TrEMBL
MDYEDMDRETLIRILREKDTVLEKLYMEREKLNYYASTDAMTGVLNRRSGLEMLNKELNL
SRIGNKNLVVCFVDVDGLKIVNDNFGHQEGDKLLINTAKILKDSIRKTDFVIRMGGDEFL
VIFPGAAMEEVHKIWHRIEEKLKEYNENNENYNFSLSCGFCECRKGMQCGMSVEDLIKNA
DFEMYKKKLQKKKEL
>A0A5E4RDU1|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MALGVSLPALDLPTLQFVTFLLSIATGILFMLDALRRDEAESPRWWSLAFLLATFSPVLY
LLAARSSRLAILYPLGNAVATLAFAMVWSGARRFYARSVQWVAVFGGPAVLLWGTWLFAR
PLDAWSGGVLFYALLACYSLMAAREFWQASGVRLPSSVVLAVVAVLHGGFYSARAVALVW
LGPSDPVFLAWFGPQVSTTEMLVLIVVASFLMVSLGKERSEIALHRAATRDGLTQAFNRP
EFTRLAREQIRRHGAARAPVALLLLDLDHFKRINDTYGHPFGDTVLLLFARTAAQQLRSD
DIFGRYGGEEFALFLPGVGAAEAQAIAERVREAFERAARTVQGEPVAATVSIGIACEERS
RGELSSLVQRADRALYQAKAAGRNRCVRYTPETAMPSVEARVDAPPLRAAAGG
>A0A564TA57|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MKKTTQKWCLRILVWLVAVLVLLGVADSCRVQEDPHRTLVQGSLQELNDSWTLETDQQAV
YDIPESMGESLMLSIRSTKQKFSLGLRAADGQETAFYTYDPGSGPAEMRLFAALPEGAAG
KTLVLRCAEPSALSAMLSSEPVLAAQTKLSGYYFRRSLYALVFFLLCVLCAVELGVLMVT
MHSIFTPEVRHQTRVLIGLMLDAGIWILTDSELLALVTDRANLVVFVSLVTFSLTAPFTL
EFVRCTIRNDGWLIRLPQMAALVLLAADAAGWLLAGQPMLWLLMPIHITVIASILAAFHT
LVVSYKKNHSGEVRNILLAFGVLAAGALLALATFYSGYRGRTYAVCYCAGLLGFLVMLGR
IVLHRIRQAINEQAQLENYKKLAYADSLTGLFNYTAFKYMKSRWPERTDWTYIVMDVNWL
KQTNDQYGHRAGDELLCCAARCIREAFYRAEDCFRIGGDEFAVIAAATDEEAVKAAVETL
RRLCAEWDAKEEYPVSIAVGYAMQAGRTMTADELFMEADAAMYQNKAEIKKAVGGISR
>A0A385ZK90|diguanylate cyclase|EC 2.7.7.65|Streptomyces griseorubiginosus|TrEMBL
MNTFVTVLAAAAPVASGWTAHVLWLRRRLNVARRDPLTGLRTREAFTRRATTLLRDPRAI
VVLADVDRFKQINDTFGHAAGDALLKATADRLAHHVGRSGVAGRLGGDEFAAVLIDDHGT
AADMLAVLHGVLARPVDGQDPAVHTTVSLGWTRAADFPGDDLSGLLRRADEAMYAAKQAH
AGSHRAGLGRLFATVTGRRAGRTGARTDAPLVGVAA
>A0A174CKE7|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MKRSKEKITLSILLAAVLVVGIVGYMIYVQHQFYTESTKNLLETYEQVDKTFTMFAQRNW
NVLSEWGSNLQDDADGEAVRASLCLSNQQKPTWKYSGLYLFNEDCTYLDAESGHGSAKHI
WGAFSEMYTTGHPCVGSYTMKNGERRVVFTVPIEPVEVDGETYTCIAVSYDNETLEEMIG
GHAYNGQSDCYIIYPSGDIMLSEEPKSEIEPRMENLFDFLEQNAQVNTNALAKMREDVQN
SGRGSVAYRYGGKSYYLVYQPVGFQSLSIVGIVDRSVVDAGMRKIQTATILLLIALMAGI
VFTLVRFVRINARQEVEEKEHALRAEASERKKMEGLANSDGLTGLFNERCFNKTLKEKEQ
QGKPFVLFYLDLDRFKPVNDTYGHDVGDQLLKAVAGRLRSCVRNTDYAFRIGGDEFALIV
NGEVDAEWCAQRMETIKSIIRQTYVLEGQTIDISTSCGVVCYPADSADVRELRILADQRM
YEDKQKTGSSRSIKQKI
>A0A173V8N8|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MDAIAHTQVSGFCLVTLAVLLRAQQKMRDKSLPGRQFTALLWFAGALTIVDYGSALAQLG
AWEELGIPLTYRLNAGGSILFYLLAACCCLLVFLYVEAELGRTWMEDGRRLALSAAPVAL
LLLVLLTARDENGFYYLDAEGLRGSTLFWGAKLVGLAYLAAAFLRCSWTLSHWKQETPKE
ELKTLLLLALAPAAGFLLQGWLPGRGLLCCGITLGLVCVYVLVLQTKFTVDTLTGVSNRI
VALRYLESELPYYRRHPNRSLHFLMMDMDHFKHINDQYGHLEGDAALVLLAGILKKVCAN
YNGVLARYGGDEFCIACGCNSVEVRTLIASIQRELDAANAASGKPYQIEISIGCARLEPD
IATVHDLIDKADQEMYHLKTRKHGTAPAEKQD
>A0A1Y6M9Q7|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MNEISLADFHLTMQVLDNLDAGVVILDETYNVCAWNTFMQAYSGISSMQIMGKSLFDVVP
DLPQSWLKNKIRSTFKLRMHSFSAWEDRPWVFRFLNFCPISGSSDIMYQNMTLTPLRSLS
GEYKHICLTITDVTDIAKNKNHLHESNKQLTHLSITDRLTQLYNRGHWENCLADAFEYCQ
QTQTPATLVMFDIDHFKRVNDTYGHVAGDGVIKVIADVLRRTKRQTDIAGRYGGEEFGII
LPGTSAELAGYFTERLRNRIEKETVFDDQRGIVKVTISLGVCEWNPKLSDYKSWLEKSDL
ALYESKKKGRNTTTIINSDDCYTDSKGEFILTEVDANTTIN
>A0A8H9S078|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSRLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLRISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>B1EM07|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii (strain TW07627)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHRIINVLSTQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQMASLLSWEIEIIYKVLLNSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDIKPGE
>A0A4P7J7I9|diguanylate cyclase|EC 2.7.7.65|Citrobacter tructae|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
HSLEASLVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTDKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLIARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNQHQPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKN
>A0A5C5WVR1|diguanylate cyclase|EC 2.7.7.65|Rubripirellula amarantea|TrEMBL
MPFSKPCSDACDDTVADINAEPKKSPPELRFAPLGGAAHFAVTLLVVNAMAWTFVFNPSG
AIDGGALAMGTSVIILALLAHQAICRREGSGFHKNAALSGQLEAILDQMPDGLLITDQHD
RIVIANDAFLRSIGMTKEDLIGRRASSLSWVHGAARETRDLPWVQASRQSTSRDQQLMRY
RLPGGEERYFSINSSPVKSDDDDQQGALMTFRDVTQIENHRAELEQMLVMLRSSREEIRT
KNHELRVLADIDSLTGCLNRRAFFEEFRRAWEAAQERQHPLSCLMLDVDHFKQVNDVYGH
QWGDEILQLVSTILQNQFPEPSLIGRYGGEEFCVMMPGISLADAMQMCEQTRVCIASHRF
WDLPELNISASFGLATLNPGVSRVEDLIRQADECLYMAKENGRNRVVSRLEYRRLAEDQA
DKLDPTSVR
>A0A5C5WL38|diguanylate cyclase|EC 2.7.7.65|Rubripirellula amarantea|TrEMBL
MTSTNLPNATAFPSSEGIQTSSDAVVITTADMRGDKNPSVGLDETMDPILAIEEGRQRVG
KLLAGLQESAPRTESFSYSPDDVRFENHLAVVRLGIATSLFYALRTKHAATAAHCLRVAL
SCSAWAERMKLDDETRDRIEVAALLHDLGKIGIPDRILRKPGKLSVDEQMSMELNPPLGV
EILRGCTSDNELLDIVLHANAWYESRRHGEGPRGDAIPFGSRMLAIVDAFDSMTTDTVYR
PALSRERAIEELINSSRTQFDPELVLDFSRMLEERPEILQGCVVNRWLKGLDQSNKDTLW
TGPPKAATPSKQVVRRESLYYQQLLGNMSDGVVFTDAEGVITEWNHGMEAMTGIPSSAIV
GKRWAHESLRLRQPGDNKDDEACLVEACLRSNSVVKQAMLIEQPGNDPTPVHLTVAPVMG
LQPGVYGTVTIVRDMSDQKTLQRQLETLHKKSTMDPLTQVANRSHFDDRLEAATRKATLG
KSSFSLIICDIDHFKSVNDVHGHPAGDEALKSFAAVLKMHSRDGDLVARYGGEEFLLLTP
NCDNATASQRAEAIRAALEKTPLASLNDESVTASFGVTEFQPGDTPESVLARADRALLKA
KDNGRNRVIQLGAGNKVERVAQDDAGKFGWLQWLGASTPAQHGEFDIITPVPVDLAIEKL
RGFIADHGAEIISVKENQLAMKVNAYYTKGGRRRADQQIAIQVQLTLSDANVERASSDTR
SVKKAVVSHTNVHVHLTPIRNRDRRNREVSTCFNQVINSLKCYLMGDVKRCEG
>A0A379CPL2|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MMSRLHNEINLSFLKMYSTLRRVKVAFSNSAAISNPNLPIITAEDGVTLVVNPLHHAVPQ
LYESLNKIKNLLDLESDNHTHLLSLVQKNGQYGYFTPYRPHYQAILNSLAKDPESLGILK
KYHLAEEFDESLLFCDIRTSEVYKEEYSHQQMLSIFMPIFDKKKVSALAIVDLNSDFIAY
KIRKFNKENNTYFQLSDSKGMALNIPCITTQEYIYNPRFTPDSWHHLLFSFAIATLATLL
FNSYFKLKGVAFRDKLTGLHNRSYFQRKQHSLRHCYSVILMDIDDFKAINDHYGHDTGDK
ILRGMAEIIQRCARKDDLLIRWGGEEFLLVLYTDNVVVAQERAEFIRKTIAETPINGLRI
SVSIGVSACTEQSFELTFKQADIALYQSKALGKNQVTLFRENTENSIPPDVSH
>A0A200NUP3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQYKFSHRVQAVATAIDTHLVSNDFSALRPQITELMVSADIVRVDLLHGDKQVYTLARNG
SYRPVGTSDLFRELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFL
AVRWLQRQLAGQELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLREIQNAREQH
SRLDTLIRSYAAQDVKTGLNNRLFFDNQLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTW
GHSQVEEQFFTLTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKEAESIASQLIKAVD
TLPNNKMLDRDDMIHIGICAWRSGQDTEQVMEHAESATRNVGLQGGNSWAIYDDSLPEKG
RGNVRWRTLIEQMLSRGGPRLYQKPAVTREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQ
FGLSEEYDRLQISRLIPLLRYWPEENLAIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRI
IIELAEADVGQHISRLQPVISLVNALGVRVAVNQAGLTLVSTSWIKELNVELLKLHPGLV
RNIEKRTENQLLVQSLVEACSGTSTHVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPL
DTNVKKYSQRYSV
>A0A7Z8GHV2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8H9DCL9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSQCYTTKWRDIPL
ARLG
>A0A1H8NF41|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MKLLATLAKIAARLAPSRRGSQTVIEALQSAVAEKEQQLEQQAIALAHSRKIFDRSSEAA
RIGVWECSLPDNRLVWTKMVYDLFDVPYEADLDRAEILKCYSNESLAELVRLRSRAIQEQ
SGFTLDAEIVTPKGNTRWIRITATVECEGDVPVRIFGMKLDITAEKMMFDQIRYLAEFDI
LTGLPNRAQFQTAVQRLPLRYISGSTAALLLIDLDGFKGINDTFGHQAGDECLKETAERL
LAACKGADLVARIGGDEFAVLVSGYDSAASVATLAETVVHCLNRSVERDGARMHVGASVG
VAFFDASMNSNIFVCADSALYKAKADGKNRFQVHEIPACIDNPKMDAA
>A0A8H8ZAL2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGGFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPLTVML
LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL
LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKK
DGRNRTSTMRYGEEVV
>A0A658Z028|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVIEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A380AQD8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A090F505|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp. ORS 3359|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTANNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCKRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRDFATEDVKPKVLLIDERRSSVERIQKMLRNSAE
LDVATDPNAGFFQAAETPYECVLISTAFSGFDALRLCSQLRSLDRTRFLPIMLLADEGEE
GRILRGLELGINDYLIRPIDQHELTARLRTQVRRKRYNDQLRASVAQTIEMAVIDGLTGL
HNRRYLDSHLQTLFDRAAARRRPLSVMITDLDRFKSINDTHGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGAVAEKVAERIRAEIAQAPFVIGNDGKTIEVTVSVGV
SSLLKGTDSVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A1V4VLU3|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MKDEYKTGEQLADELVRPCLGATDLEKKLRAEKLQLLAICDNINEIMYVSDPTTYEILFV
NKTLRELHKKELVGSICYKEFQGRESPCEFCTNNVILKDKGKPYKWEHYNPLHGRNYMIE
DKAIRWPDGRDVRFEFAVDITNHKKVEEAIRRRLEFMDIVKRISSRFVGVSNIDEAINDS
LADIGIISGAGRAYLFYMSQDETTMSNTHEWCNDGVLPQKDTLQNVPNITLPWWMDKLHK
GEVIHITDVSKLPREAQAERDLLEKQDIKSLISLPLYVNGKLSGFIGFDNVTGTGSWSDD
DLALLRVSSEIIGNAYERKLVDEALRESENKYRTIFENTGTAIVILEEDNTISLVNSEFE
RYTGFGKEEIQGKKSLNEFLRDYSRGIKKHFPLVDNLPLNLESHLVDKMGNTKNVIINIT
RLPGTSKYVVSLLDITEQKRIEKQLKYLSFHDTLTGLYNRAFFEEEMRRLGNERHMPISI
IMCDVDGLKLVNDTLGHHAGDELLVSASGIIKKCFRKSDIVARIGGDEFALILPNSNRNI
AEKACCNIRNALAKYNAANTKNILSLSIGFAVKDDPSVSMAELFKEADNSMYREKLHHKE
SARNAIVQALTKALAARDFITEGHAERLRSLVASMAAAIGIPEYKIADLRLLAQFHDIGK
VGVSDRILFKPGPLTPEERSEIELHCSIGHRIALAAPDLTPIADWILKHHEWWNGKGYPL
GLKEQEIPLECRVLAIADAYDAMTSDRPYRKAITHEAAVKELERCAGSQFDPVLTPKFIR
VLEDIRSF
>A0A1C3JHL4|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MASSFVTSSMFRFCFPLLLLAMLFVGMNNVILVTDSNLGFASNLPYILLSVAVLLCHTFR
QGRMAMVSLTMLVAYLIIQVRLQTPLNTGTTLLELSILAALVPVTCLLVYAFPDNGVNSK
SMLLYAIVLILFMVWAQLIVSHFHAGGFKSWSEGLLFIVRDFSKLPFVLVLYSLCLLGLT
AILVLVYNRSIDVVVYSAILLSCCTFIFFDVQYISSTMFSLSGTLIIVYVMSASHDMAFN
DQLTNIPGRHALEVDMKHLGRKYSMAMVDIDHFKQFNDTYGHDIGDDVLKLVARILRETT
GGAKAYRYGGEEFTIIFKGKHSEQVKEHLQALISEVQNYDMTIRNSHERPDDHEVGMKKR
GKNGKPSEVVNVTVSIGLSDSTTTRHPEEVLKLADQALYKAKETGRNKLCIDR
>A0A839VRZ7|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. OGB3|TrEMBL
MSARVLVVDDVLPNVKLLAAKLTREYFNVITASNGPEALEVVRRESPDIVLLDVMMPGMD
GFEVCERIRSDPATMHIPVVMVTALSDGADRVRGLEAGADDFLTKPVNDIALFARVRSLV
RLKMMMDEWRLRETTSGQFGVLEPTGTLRSESFEGARILVLEDSLLDLAKIAETLQRDHG
HVMSAGTCATALERALGDDLDLVVISLTLMNEDGLRLCSQLRSHERTRQVPILLMVDEGD
LNRVAKGLELGANDYVVKPIDRNELLARARTQIRRKRYQERLRANYEQSLSMALTDSLTG
VFNRRYINAHLPRLLERAIDNHKPVAILLFDIDHFKVVNDSYGHTVGDEVLKEVSSRASR
NLRTFDLVARLGGEEFVVILPDTDAEAALTVAERLRTRIADTLFKVTADVGEIPVTVSIG
VAVGGRLGDTAEGLIRRADEALYEAKRAGRNRSIADPRADALLAP
>A0A518AYC7|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan216|TrEMBL
MSRSTTMALLTYFSQQPNVLVLVLALTLIIFIGAIDARDSYELSSSLFYLGPTLLAAYSV
GRWAGIGLSLVSALTWLVADRIAVHDYTSPVAQYWNAGFQFVLFLIFALFASSLRAALER
ERHRANTDGLTGVANPRRFLELVKADVVQARATGCPVTMAYLDLDDFKLVNDRLGHGAGD
ELLRTVADVLRDHVRDEDVIARLGGDEFAIFFFDASYETAGEILERLRRDFLSEMRRHES
PVSFCIGAATFVEIPDSVNELISEADTLMYLAKAKGKNAIEHRQVEPSRGVADHDG
>A0A105T590|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. TAD18|TrEMBL
MKRKRPLATPRLLGIVWPFIAVVLFQALLGCVSLYMLSAVRGYVAGESLWSKGQKDAIYY
LNLYADSRDQAIFEKYQQAIRVPQGGHNLRLALDQSPPDLSAAREGILQGGNSPDDVTSI
IWFYRNFRDFSYLDTAIQKWTVGDDYLVQLDTLAQEIHQKISANQATDADVKRWKANIFA
INEAVTPAAKAFSDALGEGSRFIQQLLIFINLATALMLILLALLRTHKILAQRRAFAQAL
EVEKERAQVTLESIGDGVITTDVTGAIDYMNPAAELLTHWKAQQAQGVPLAALFKLLDEN
AQDDGFKLMDHILSGQLGNSSEHSKLIQRMDGSTVSVTLVGAPIFSAGKVSGSVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLDLVLQNLGRQHGRHALMFLDLDQFKLVN
DTCGHAAGDELLRHICALLQSGLREGDTLARLGGDEFGILLENCPPDVAEKIAEGLRQTV
QSLHFAWKGRPFLNTISIGLVHIHQAPVTLEGLLRAADMACYMAKEKGRNRVQVYHADDS
ELSLRFGEMAWVQRLHVALEENRFCLYAQEITPLGQDIEGGHIEILLRLHDESGHIILPD
SFIPAAERYGLMTSIDRWVVENVFKVIAQCTALGSDQPMAMCAINLSGSTIGDDDFLAFL
HEQFECYAVPPSRVCFEITETSAISNLGSAIRFINDLKGLGCHFSLDDFCAGMSSFAYLK
HLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALIEIGV
DYAQGYIIERPQLFTCDSLLCRPKRALPLAMKAPGTFR
>A0A564G406|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MNRPPKAVSADGGNVHLPRDRWCAEAAWTTLQARGVVPTPRAYEVLFIHFSGTDPEISRR
LLPLLCDERAILDEHLEELHELCRANARESDETVDASAQALTDTAEGLLEDIGSNQRSLC
GYGHHLALWATQLRQQASVEELLKAVTVLSLETGRAGERNRLLEDQLSAATVRIAKLRRE
LADARREAEVDVLTGIPNRRAFERSLRRTVAEAEAGAGGPFTLLMLDVDHFKRFNDLHGH
RTGDNVLRVVGRLLADGVKAGDTVARYGGEEFAVLLADADLRVGAAVADRIRTSVEACRL
VKKDSREPLGRITVSVGVAQYGPGESGSDLIHRADEALYEAKREGRNRVRPIPVTDASIR
>A0A080M6W2|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-02|TrEMBL
MSNPTPRILAIDNRLANLLTLRATLTPEFELQFASSGTQGLAMAAESPPDLILIDLMMSE
MDGYETCRRLKADPRLQDIPMIFLTELGQAGTACTEQVPSPTDTVFTPPILAEITRRRIR
NLLHREQLRRAAEKYRKHLATREQALLESEAFTRTILNSLTENLAVLDPQGVIVSVNRAW
QRFAEENGAPGLATNSVGLSYRSVCMAAAGQPGGDEALQAWAGIVAVLTKTQPHFSHEYA
CNSPDRARWFRMRVDPMLTPGKGVVVVHEDITPRKQAENALREQEAFFRLITENLEGFVA
VLDIEGRRVYNSPSYARLLGDRNLCGTSSFTDIHPADRERVVGAFHETVATGIGHHLEFR
FVTADGGIRLIESRGGVIRDDEGRIKRVVVVSHDVTERKAAEEQIHHLAFYDALTQLPNR
LLLNDRLQQSMAASKRNACYGALMFIDLDDFKPVNDRHGHAVGDLLLIEAANRLKTCVRA
ADTVARFGGDEFVVILSDLHVDKIESSAQAAIVADKIRIRLSEPYVLTIRCEGSTDSIIE
HHCTASIGVTLFHDHVASRDDLLKRADAEMYQAKQAGRNLIRFHEEKDGVD
>K8DZ55|diguanylate cyclase|EC 2.7.7.65|Desulforamulus hydrothermalis Lam5 = DSM 18033|TrEMBL
MLSRHNFNLQDINQLEVELFIGRLRKVLVGSGLLIWTLLVQFNAISPGQGTAVALAVIYC
FWIEKYYRNYGVKGWQYLSSSLDFVLIWGILSLMVNFQPHFLGLFLVNAVLLAMRFGLAG
WPWLVANGLLFSGAVYFGGHWDSYSWQIIWLLLVSVLSTRLAQQHRQMDRRLLALHRLSH
HFNAALRVSEVIQKALQELKSIWPNNHISIAELNCQGDFIILGSTRNELPGKLELGTAVT
TQLVQQQEMAVIKNTLLDKRLANDFLKKFYLRSVLLVPVVVQGETTGLVILEAPALQDFN
HDEMAIIMLAATQIGISLKNAGLYERMENLARLDELTKVYNRRALYDVASQEFILAHYKN
SRLALVMLDLDHFKKINDEFGHPAGDQVLVRVASVMKAHLRQGDSVARYGGEEFVLVLPG
ASRQVALEVAERIRAAVANLNWQDGWQVTVSAGVAAYPEDGRDLPELLKKADLALYRAKA
RGRNRVQAYGGNENIINLDTSKTSAG
>A0A7Z7RJW9|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MPTSPAEQDESKLLLDNLVELTSQREQEMLESSLLSTLVELMHVDRVELFACRRVNGSPY
LCRRLEALAASGKPEVRETPADGWLPPSPFLRELFSHAHHDNTALLRIPSGLCLPLHCMG
NITSLVVIHCGPDADVNRDMLLAMARIHENFLRLLFEADRDMLTALHNRRKFDLRFYNLI
ASLQHEAESAATHMLALLDIDHFKQVNDRFGHMVGDEVLLLMAQLMQASFREEDGLFRYG
GEEFALLLECGDAEPAEVALERFRASVRRHVFPQAGCITISIGYTPITPGLLPDQLLEQA
DRALYYAKSHGRDQVCGYEKLVAGGKLESPLIADQIDYF
>A0A1V5V499|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin236|TrEMBL
MKSTDIIQTNGNGKHNPIAVIAGGFSLAVFIGATDFLTGPYLAFSIFYLIPVMLATWFAG
RAAGFCLALFCAASWFIAEKLDPLQYPHFLIPYWNAFVRLGFFLVCSYLLALVKRALEKE
KSISRTDALTGAENSRSFFETAEIEIEKMRRRGTPLSAVYIDVDNFKGVNDTLGHSAGDK
LLSMVVHAVKQELRSIDTIARMGGDEFAILFPDTDHGGAEKATNRIKNKLDATMSANRWP
VSFSVGVITFSKPPFSVNEMIKEADSLMYEVKNNGKNAIKTKVI
>A0A2X1B725|diguanylate cyclase|EC 2.7.7.65|Brevundimonas vesicularis|TrEMBL
MSTDHALPSFDRATQTESRLRSHPCAVTDVAEHDLTAEIARLRVELEAWKTRAAAAEAAA
DHDVLTPALNRRGFITAMQRTMAYCQRHGVPAVLLYLDMDGFKSVNDSLGHAAGDAALVA
VAELFLANLRESDAVGRLGGDEFALLMLHAGYEEGRAKARQLAEALKTEGFVWDGQKTEL
GGSFGVRAWDGHTDPEVWLTEADAAMWVRKKGR
>A0A136JXU9|diguanylate cyclase|EC 2.7.7.65|Nitrospira sp. OLB3|TrEMBL
MIKVLLIEDNAVDAQLTRDLLSTWPHDQFVITHAATLGEGLIRLSRDRFDVSLLDLSLPD
TNGLSTVTQVLATSPGVPVVVLSGHDDHPLALQALQHGAQDYLVKGHGEADFLARSILYA
IERKRAQERLTYLAQHDPLTGLINRTLFRDRLLQAMARSKRKDKPLAIMLLDLDRFKAVN
DTLGHDVGDQLLKTVAMRLTDCVREVDTVARMGGDEFTAILEGVSGEADVAVVASRIVEA
LSSPLELGPHRVTVGVSVGITLYPSDDQDLDGLLRHADKAMYAAKHEGGNRFHFHSPADR
>A0A1J5S5V2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MALDEVTRDELQSIIAQLKESLYNHQQWHGTLIRTLVCKLPGDKHDTNDTAHMECRFGQW
YYSNAPEKLRKHPGFIALGDEHQRLHHMARLLLIAADAGNPIATLDFDNFANALERLRLE
IFALERELENSLFNHDSLTGAITRFGILPTLREQQELVRRHAQLCYIAMMDLDNFKAVND
LHGHAAGDTVLAASVRYLIKHLRPYDKVFRYGGEEFLLCMPYTELTSGHGRVRELNEGLA
AMEIDIGKEEPIRITASFGLALLDPDVPVEKSIDRADKALFAAKSAGRNCVLIWDSSM
>A0A378UQD4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MGEREFAIATAVLRATGYLNAIRIFIGVASISLGLLSGLEQIQSIQPLGPHGLFARTVHL
LLLVSALLVGGLWLSSPWPGYRRAVAFAVWGDVALAVSGATLAAPEARLAATVYMCLIGV
FAAVLLGYRVLFLHCGFATATILAFTWMGVQFDGAQLAELSLYFLPALTTVVVMPAIAAM
VIEGTRRSLSTTAYAANRDSLTGLLNRRGLYAETGTTWARSPRGAVLAVVVIDLDGFKRL
NDDHGHGTGDATLRVVAEQLTKLIRTRDIAARIGGDEFVLVASLLDEDDLDSFVRRVQAL
RLRDPKGLFLRFSVGITWEHVEGVHVDLDSILHRADDAMYQAKRVGGGTVVVAEPPRAGE
EQAAV
>A0A1J5R4U4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKREPLIQEVANLVCMLRSDVVGAIILTETRTDEAALLKICDPSCRIIVTKEVVSVISLV
VQRGYQGVCGISSAGQVDNSASIFRPESGCALGLLLDYEVCDEAARATAGQNWVRAFLAE
GHRLLSYAIVELLAEEPSNTERPLARHKTEKEWIDSAAALPELVASLKAENIVDKMLAVI
DAVAPRGVMPELVPASNEWVRQIVANAEPVVVERDRLFWEILQWERRNRSFRVFRQWRVF
EPFGMLYDQRYWIHDLKAFCMGRMGVDRICVFKLDLDNFKNVNTQLGHCGGDEAIMLASA
IIRDLMAGECLLYRRGGDEFVALGLDMSADHGRRVGDLLREEMEKRFSDWCSTRAVSPAV
TASIGIVFVRQFLRFDCLTESLDRTQEAAKRSGKNCVRFESLDGDRP
>A0A380A661|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MTRTMKIKYAIYFFTLCLMTSFSLFIVDELLEAHTDYRDNQLNLYKIDRAKEISEAFQAA
LLAHRLKRLSLIDPQITRAQCLAADRVARERITRIREHLDDEVARQLGVRQKIAALSMIA
LMEQLLDNDNLQLSQVNNTNANLFNINSAYYISQTSKSYYRYTYDTRMVDTDSFMFLEAI
RLNNRLNMSLTELSDQIIDVNVSQLVRKDAYLKSIQLTGVLNALSTRLIFMKINYDDGQI
TNIVNALLAQVSAERLQQITNGLYTAIDTHKPYPTALISRYVDDVSGLSQALYQRSFELE
TLASRHKIYDSQTTIYGMIALAGLVVLLFILPALVFCTSINRWLTKTHNNIVRLSRGEMN
IDRNDAFYSQELIAISDAIQQLRQYQLDKVSLESEKQLLIKELEASSFLDPLTNIYNRRK
FFLECQLLGNASYPQAFCLIDIDNFKQLNDSYGHDVGDRALVAFGHLLQRAFRASDIFCR
YGGEEFAVLLGNCSLDNARDIMEQLRARTHRLTLNLADGRQVRFTTSCGIAPVSAFAALQ
AAIKQADEALYFCKKNGKDRVSVHTQAGFI
>A0A1C5L2G0|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKSIKKYETIINEALRSALEYDTPEGQINEFISFFGKHIGSDRIYIFEDDEEHHVTNNTY
EWCAEGITPQIEHLQGVNMEVIDWWYDTFDEGKSVIISDVEELKGVHQVSYNMLKYQNVC
KVVVSPLRHKGQIKGFFGVDNPPAVDYNALTMFLDMIGTMLISLLKIRNTFQKEQYNASM
SSYSALSEIYLCMHLIDIKTGKYEQIKNVKHVEKECEELDQENFSKRVYTTMKYFCTEMY
LSSVLEFVDLSTLDRRLMETNTIVHEFIGTVSGWCRERFIKVDSDEKGRLWHVLYCVEVI
DEQKRREKKLLYLSETDSMTGINNRGSGERKITEFLEKKKGGLFCLLDCDKFKKINDTYG
HAVGDTVLIKLAAVLQRACRENDIVMRLGGDEFAMYLPGMSDKAQAESFFKRLFTQIDKI
SIPEMQGEKINVSLGASLCSDKDGATFDTLYHEADAAMYESKKIVGNHAIIYSDLPQAR
>A0A2H6B6G2|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MNAATPSTIGRPTNWRDVFSSGPIAPLPALALVGAVVAWVGALVGAIVVLLPGAPLARPE
LVFAAAAGAAVLGAALALARARAGQAGLHAAMFVGTLLGTLGVLGWGSEHAFGPLGYAWV
VVAAFVFFPAWQSLLHVASVAVVYALAMVFDRGSVAWNAWFATVTALAGAGAIVTLARVR
ATALLQQLEEAAGRDPLTGLANRRSLQDAFDIELERARRTGRPLAVLLVDIDRFKRVNDR
CGHQCGDEVLRTLARVLQASKRGFDLAARHGGEEFVLLAPDCDEHGAYMLAERLRTAVER
AFADHQAGPVTVSIGAAVHPVHGQTFEALLNAADEAMYAAKKLGRNRTVISSAEIERAAE
LDVTAGGRVELAALVDLAEAVDMATIGNTSHCQRVARFAELAARETGLPAHRVEQVRLAA
LLHDVGTIAIPDEIERKKGPLTYEEWEFVRAHPVVGARMLEVTEHRELGRWVRAHHEHLD
GSGYPDGLSGADVPLEARIIAVAEAYEAMTSDRPYRPRLTHREAVAELRSAAGQRFDTEV
VEALVRALG
>A0A3S5EY33|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSRLDLQKLTLLLALVAGLLTFGNSFFAGYSSQRDQLFEQTLEANRAYARKLADTTDQFF
LNSRRELAYAAEVLSTRFADPSARDNETERLKLKSEQFSRAVIVSAAGEIVSASPESTGL
VGLKVNSVGATRALKERKPLTSDPYVATDGTYLIAVTHPIFAPDGSYLGYISASLFLRER
NALHGLLGVHYYRDGSYLYVVDTQGRLIFHEDGKRVGQNVSSNAVVRQVLSGQEGSQRVI
NTLGVDMLAGFAPMQSTGWGIIAQRPTAAITAKLEQLARTTLLNAVPFTLISLAVFWWLS
ILISRPIRALADTAEHWGAPEAASRISMVNSWYFEVSRLKVAMLAGVSLLQQKMGALEAA
SMTDPLTGLRNRRGLELALKQFDLLDQRYAAVTLDIDHFKQVNDQHGHDVGDAVLRFLAE
IMKECSRPTDVLCRMGGEEFLMLLPETDASGAGIAAERLLSRLRQTASPTGAPVTASIGI
ACSDRYASSDATFKAADEALYQAKRAGRDRVVLASA
>A0A1C5VJF5|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKNRRKNMKKRGVPLALYLTVCLAIIVSAYFHLSSIAQNFNTQHLELITGLYAEKMNESM
EYLQNYVKEDVKMIQAMENKEPEKIQKRLEKNLNQKMFCNVGFILKNGDVYGSKCAVADI
KKKNFDKQALSSAISFNSDPYQSSETGNMIMTVFVPVADDSQIRTLYVSIMIEQLRKLGV
YELLQGKISVHLLKVDSENFITCISSNEDTTANGWNNLLLQQKYFKYDENYSYKQWIKDM
RSAKKEGRFAAQIKGEDSTISYRSISGMPGWYIVVELTNKNISDITQHFSIWGGVYGSIL
VGFTILYMLMLLFMEKKEKKRYIGLSSTDALTGILNRRAFQVELEEQICKKEPGFFIFID
VDNFKSYNDTYGHNNGDLCLKHFTKAMQECFPEGSILSRYGGDEFVVYLKDVTKESVYIY
MEKFQKMIADLTLATGEQVHLSASAGGAAFPEQGEDFISLCRSADVALYNVKQNGKAAFK
IK
>A0A8E6WGU9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQSNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F6GV84|diguanylate cyclase|EC 2.7.7.65|Methylococcus sp. Mc7|TrEMBL
MHKPTLCDSLPTPSRTAAAILSLAQREDVTAEALAQLIQTDPALTGRILRFANAPAQGTR
RPIASVIDAMNLLGLPAIRQFALSLSLIDAHREGRCEAFDYAAYWQKSLACAVALQSITA
QVPTVAPKEAFTLGLLADVGRLALATAWPQEYGECLRQADGERLIALERERFATDHDDLS
RMLLTDWGFPQVFIDALELSHRDEIQDDGRTGRFARQLVLARRVADYRLAEEPRRMALSP
ILQVEARKCGLDDEDLAHLLGGPQAEWLDWTRMIGIADDDQTGSAEPSGQMPQADEKLHV
LLADDDPLMLTRLSRQLEADGHHVASRRDGEAALEYALEHEPEMVITDWHMKPMNGLELC
KALRASALGGNVYIVMLTASESEDALVEAFGAGIDDYVIKPPSVRVLKARIWAGQRIITL
HKKLARERKEIERYSSELAAANRRLELMAHTDQLTGLPNRRYAMDRLEQEWAEARMFGRP
LSIMMLDLDWFKSINDTLGHDAGDQALVHAARVMRETVRTSDIVCRMGGEEFLIITQDTG
GAAAIQTADRIRSAIERRQPLDLELSRPLTASIGVADSASATSLKDLLLKADNALYQAKQ
NGRNGVRYAMA
>A0A518C597|diguanylate cyclase|EC 2.7.7.65|Bremerella volcania|TrEMBL
MFLFLLLMIGANLLIGFCAAVRVRQLIQSQPSIVSVETAEVFLNEFENQTVSDQNSNTPK
SEKSRPEPEEVIPYEYLSALEEEAIVANSLVEASAQVLRLEIGKYRARLVEIENQLRETW
YQPTEDALHGIAEQLDTVNIDWLDKQAEASQHLDSSKEGLGAYADIGSRLCDTLFEQTAQ
IETTLSNLQQIDFQDNLNDVCRKLVLEIARLIDLCHDLRDKMTETIVTVLRAEKRLGTVD
KGMKLDSLTGLKNRTGLECQLFEWWRDDIRRERALSIAALDIDEFRKFNERLGTEAGDKI
IGAVGKYLADCVRSERGFEYAMRLEGQRFVLFFGDVGPRGATSAVERIRQTIDGTVFEYD
GEELELHISAGVTEAKPDDTVPKLFTRAMTSLRTAKKNGRNRTFIDEGQGPQPIDPPTYP
IRDKVITIQ
>A0A7W6MD08|diguanylate cyclase|EC 2.7.7.65|Rhizobium aethiopicum|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGHEALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGMGDLMRAGEGRGDEAGQVLLVDGRANSQERIVRALKPVAD
VLALSDPQAALFEAAENTFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
DMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEVAAAVAERLRAAVESAPFLLKRSSEALSVTASFGI
ASRIGAVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A2X0XMB7|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MKIGEVIEKVPCIDEFVKNKELDVLFTSNPSLRSVVVVRDEKPIGHITRTHFYQKIGTRY
GYHLLMERQNQLMIKKNPLIVDRNTPITEVSTLAMARPPEDLYDDVIVTKNNLYYGMVSI
RELLLKLVDTQVAIASFLNPLSSLPGNKLIDEKLEEALQLSQYSLIYFDLDHFKSYNDTY
GFNKGDKILRYLTEILKRHICGVEDFLGHIGGDDFVAILPYYEVEKMCQKIIDDFDANIL
SFYELEDLAYVQVANRSGELEPLTCTSLSIAVITNEYQYFDSVEQLSNAVTHVKKQCKKI
AGSCYLINKQQNYFVH
>A0A2R8CGR2|diguanylate cyclase|EC 2.7.7.65|Kushneria phyllosphaerae|TrEMBL
MQEDATELDRALEGKGRLDRVTIPAGRRSAFAAMTLAPRRRALSMSVLIGTSFYVAFAPG
DAFAVPDQRHLALIFRLAIMLPIGMAVFYWLRHARCSLIRQQLVACGFHLLAVSLLALLI
TRSDSINALGFVFANYAVLMAMVISMALPLRLVLGLATIVVLIQGMAIAYGPLRLPVLEL
HNVMIAIVIMGPAMFANRTLENERRRHFLLVEREQLRQRQLAEQRDMLGRLAALDPLTDL
ANRRGFHAGLASDLDRLAPGAMVAMAMIDIDHFKAYNDHYGHAAGDEALRRVAQALADAA
RPAGRAGRMGGEEFAVFVTGLSGNELALYAERLRASVQRLMLVHHHSTTASVMTISVGVA
LGAAGTSETKVLLGAADAALYRAKAAGRNRVVIEGLDRPDTGVSRTG
>A0A5I2JWV2|diguanylate cyclase|EC 2.7.7.65|Salmonella blockley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWELLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6I2I880|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT691|TrEMBL
MNKALATTHRPTFKRTLRRINTISIVITMTLIWLMLSAVSVVSLKQYAQKNLELTGATLS
HSIEAALVFGDETAATDTLAALGKQGQFAQADVFDRGNRPFAHWAYESAASSERFNLMLS
HWLFPKPATQPVMHNGEVIGQIRLTARDSLIGHFIWTSLGVLTTCILLATAAAMVISRQL
HAGVVNALQNIADVAHDVRTNRNFSRRVPEEKIEEFHRFAQDFNSLLNDMEQWQQTLQAK
NDQLLRSAMHDALTGLPNRALFRTRLQALMNDPKTRDSSALLFLDGDDFKEINDTFGHAA
GDCVLIETAARLAGFGGKQHQAYRLGGDEFAMILMEVSSEAQVQRICTGVAQQFSHPTDM
RNGQTTAFTLSIGYALSWEHSTVETLLEQADQNMYLMKNQRIKTES
>A0A8B4S9H2|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MIRANAIAKRTITGQLLEIAMAQSFCAVMITDARLDGEGPVIEYCNAAMCEMTGYTEAEL
LGRSPRMLQGLLTDQLVLQRLRDCLHQGLSFQGSVLNYRKDGSTYHVEWNISPVRDEKDV
IRHFVAVQRDISERVQAEQERALLARALNAANDGILITDRDSTIVFVNQAFEALTGYSAA
ELLGKPTEMLRSGLHEPEFYAQLQEALSLGHNFRATFINRHKSGGVYYAEQSIAALRDES
GQISHYVGASKDISRMVQREMELRERANRDKLTGLLNRHAGETELKRNQLQAQNQLRPYG
VILGDIDLFKQVNDRFGHVAGDRVLKMVAHVLSGKVRRYDHAVRWGGEEFLIVLSDASLG
VAAGLAERIRCAVEECADPEVGRFTISLGVGLWEPGETEDDLLKRADAALYRAKHRGRNQ
VAIATGSMNMPLVQAPELLAQGDSLTFSGKSPDKPWTGAASP
>A0A518DYG7|diguanylate cyclase|EC 2.7.7.65|Lignipirellula cremea|TrEMBL
MLALIIANLPGLSIPVALAVVAVLGYVIGCRRREEIRVNQATAMRDLRRAWSVVRRLESV
SLEVRVGLETHEKTVREFKRQLVRLSRRQGGINCSELSDEADRILKPTMYLSRQLGHAYD
ELRQHTNALLAFTEVRTDPLTRVNNRRGLDETLANLFAMMCRYGATFSIAIFDIDHFKLL
NDEHGHVQGDVVLQNVAQALRDSVRETDFVARYGGEEFVVVMPETGLSGARIFSDRVRAA
IASKLEVTVSGGVAMASDKEEPAALVARADTALYAAKNAGRNRIFEHDGTELHPVPRCDE
ELALSREATLGRATGSITHAPGKPAPDTDDEPAAAECDAQKLLGNEEQDRSSCADTVADP
ITGSYR
>A0A857JP20|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MDAPTLFICTILVSTIMSLTMMILRAANRGEKYLVDWAIAGIFFISSNILAIFSLDFDLP
TTVHPAMGNAFYLAAHAAIYSGINKCINGRSTWTLTLAVFLIPIPLHHIPLVAESVEVRI
LIFYPMIFALNASALVALWRRRNDKVGKAYWPLMVVLSLFIAQLIIRAVLMFAENVRLEF
IGNQFMQTSGNLAIIGFIFLLTISFAIIVFWKKEVTLREASVTDYLTKWLNRSALSSIAQ
KEYSLSQRTRRNFGFVMFDIDHFKHVNDQHGHATGDQVLIEISRVAKSLMRNFDHCFRLG
GEEFAILVSDTNTNELYAIAERIRKTVEQTTFTTYNGPLYITVSIGFALSTDADESWESS
LERADKALYHSKETGRNKTSGETQSEDFYSLTLQHVQLP
>A0A6S6XNB6|diguanylate cyclase|EC 2.7.7.65|Ruminococcaceae bacterium BL-6|TrEMBL
MDRFGIEEIFAAQGTADRKEAAVETFIQGSTGLFLSGGAVGRAFSGLFPSPAGAAVQVLL
LLLLFYAGIRFQKHRAGRSTDRAMLEHSGCAVFDYRVPEKTVRLSEGAMKLCGLPRAVRN
IPELLDSGIIHPDGASRLACVGRKALNGARAQGVLRVRGASGEYRWFRITLTPFGKKRGR
PEDLFGVLQDVTAQKEAELNCRRERKYRKAILGSSLASFEANFTLGRYYGGGKPMPGLPS
EDGLDYSGVIGQFAGQSVFSEDREEFLRRFSLESVINQFIQGETKITMECRLCGKDGSCL
WVLFTVSLIEDTHDVWGIAYVKNIDSQKRRELSLREKAERDSLSGLYNKGMTESLISEFL
ENQAGGIHALLILDVDNFKRINDTKGHQAGDSVLARISGILRRIFRSADIVGRIGGDEFL
VLLKDIGSSEIAARKAREVCRTLCVCVGPEEREFCSVSVGIAMYPQHGTCFSELYRKADT
ALYQAKYSGKNRYVLYEESSSPQFWDHSAGP
>A0A0U1NIG8|diguanylate cyclase|EC 2.7.7.65|Nereida ignava|TrEMBL
MNVAVSPAFDVVSVNLLQTLLPLHIVVSDGGFITQAGATLSKISGDGSLVGELFDDVFEV
IKPAGLQGRRALLATVGSAVHLRFKKPPYTRLKGVVAVDHREGLTVLTLSFGIGVVDAVQ
RFGLTSRDFAPNDPTIEMLYVVEAKSAAMNESRKLNDRLQHAKLSAEHDAQTDPLTGLHN
RRALIQVLESAISAARKFTLIHMDLDYFKAVNDRLGHAAGDAVLSAAAGVMQSHFRGSDC
IARTGGDEFVAVMMDTTDGNAVKKLCERLITAIEVPIEVDSNSAAISGSIGFTCSAQYNV
PQIGRMMNDADHALYASKRGGRARVTQFEGLSDGATKMNGGPS
>A0A7W6G474|diguanylate cyclase|EC 2.7.7.65|Rhizobium skierniewicense|TrEMBL
MTARILVVDDIAANVKLLEARLSAEYFDVISADNGAKALAICASEQVDIILLDIMMPDMD
GFEVCERLKANPVTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLISRVKSLV
RLKTMSDELRIRAEAAKTIGVGEPICEDAQIELPGRVLLVDGRASSQERIIKALKPVAEV
CALAEPGNALFEAAEGDYEMVIVNSNFDDFDPLRLCSQLRSLERTRFLPLLLVTEQGDEA
MIVRALELGVNDYIVRPLDTNELVARTLTQIKRKRFNTRLRENLNQTMEMAVIDDLTGLN
NRRYLDNHLKVLFNRAATRGRALSVCMTDIDRFKSVNDTYGHDAGDEVLREFAARLRSTV
RGADLACRYGGEEFVVVMPDTDMEMAASVAERLRFIIESRPFVLRSGRELHITASLGIAC
NAVSVETPDALMRHADQALYEAKNAGRNRVCAAAA
>A0A857JLW4|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MANSNKNNEKNAKSSSLLDTFSLPLVNEKMNAFSRMANVIAEAIFIVNDEGVIEMINPLG
AKFFGAPQEALVGQKWFSFLHERYREQYEYLFLNWNQNIELPLSHGPKEVLVERADRTWL
EVDLSVSCLPASITESAPFYVGVMHSLTKHKSEYGELRRLASTDHLTGLANRHNLEKTLQ
KSWLECLNTDQAISLILIDVDYFKLFNDQYGHVNGDKCLQKIAKTIEQCLPANDCMAARY
GGEEFAVILPRLPSVSAEIVAKDIQNQINILKFSELGLPSTFRVSVSQGIATEFGGRYRT
SEALICAADTALYRAKSEGRNRISISL
>A0A7H4S9Y2|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEELQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A286GK82|diguanylate cyclase|EC 2.7.7.65|Caenispirillum bisanense|TrEMBL
MPGRARIDDITTRTVEGLWRIWRSADPGLRTRVADIARRDSDALAEVFYDTLMRDPAAAT
FLSHDLVQTRLRGSMAKWLQAVFAIAVEDDVRAVVATNFHVGSVHARINIPLTLIPAGMR
VIKRDLTRRLVAEASLPPAEVADAVLFIGELLDTLTDTMHEAYIGDLVGNVRHQQSLKMF
MSGQNLAFESERLKGSLLDWLRTVVVGLYERGDAPPSVPSLETSDFGLWLNHKAELTFGA
APELDALRARVHEVTERVDAAVAAGGEAVGATFVRQLDRDVTEISYLLGSITARAVEMES
GRDSLTRLLTRRFMPAIFQREVAMSLRHGKPFGVLLIDADHFKQINDTHGHDCGDRVLTT
LSELLMSTVRAGDFVFRYGGEEFLVLLAEMDAPALAAKAEQVRDAVANHPVTLPEGRQLA
VTVSVGAALHDGHPDYERIIKAADAALYEAKRRGRDRVVLAGAAD
>A0A379IYK7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MSQANKPPSIIELYPEETREAAELLKQAVPLMMRHDIPPNPVHYALWYTYSRGSEPELNR
RLDKVVEDFDVFPPETASRLFRDYIIRGELDEARAGQQQVIELVDDIEGDVSRSVIGSQH
YQQSLSQGLCALHEPIIDDLPSVLSELQESTQLMQDQQEKFLYRLRAAQQEITHLRSQLE
RAHLAATLDSLTRVFNRHAFTRLLERALNDSQQGLALVILDIDHFKQFNDQYGHPLGDRV
LQHVGQLLRDLLPPEAFAARYGGEEFCVVLRNCSNLDEALDFAEQLRNKIQSLRVKVRRT
DQVLDSITASFGCAMAEEDDTFESLLTRADDALYQAKRAGRNQVHPIASEKMLTA
>A0A448L172|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MTHNPRPIDHLLAYSMLPVWVGAVLMLLIVIALSQIPAVERLEEQRMREHLQRVCRAVQG
DIDAINAFTRDWGIWDETRTFIAKPNRGYINSNLLVDTPMRDFELNLLSYLDLQGEEVWT
RTMLPDTEGVDTTLLPRFLDELTSRLLAESRQGQMRALSGVLGSQWGPLIFSLQPVTDSA
GLHQPNGFLLALRWLDRRYMAKLAERVAIPLRFAPPVSAREMAGFDTLGNRVRYRLVDLG
LRWVRGEGLLLDSAGNPVLTLIVEEERDVLRGALEGTLWMLFGMLLISLCCILIARQRLR
SIVLEPVNELVTALQHFSEQPDVSRLPIFDSSWEMALLSRKFREMAAKISLQHSAMQAHS
SRLEMAAYTDPLTRAFNRRYLEEWLLARYELAEPRLAVLLDLDHFKRVNDHFGHDMGDLV
LRQLAALLRHSLREGEPLIRLGGEEFLLLLSRQDGQVRLASLHREIAAYPFGPETAPLHM
TVSLGYCDYPLHRELEESFWELSFKLADIALYRAKQEGRDRWQGFDGELPREWWASSPEQ
IVAGGVLNYRTSGPAEDTSASGPATPAR
>A0A3S4WRU4|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MKNQIPSEQRITLRQSLGRTHMMTSLTAVCMAGLFLTITALLALRLYADHNLELVARAIS
YTTEAAVVFHDEEAAKETLQAIASHEDVASARIQLADGQVLASWTRAITTPWSSLEQQLA
HLILPGPVELPVLREGKEIARIHLVGHGQYLLRFLLQTLMATLLCLLLSILGALYVAHRM
QYSITDPLKALAQVAHSVRRQRALKQRVPAADIAELHELGEDFNSLLDELEAWQLHQKRE
NASLLHQATHDPLTGLPNRALFEARLDQSIMTGRAQHERFALLYLDCDRFKQINDSLGHA
AGDEVLVTLARRIQHQLRPMDLVCRLGGDEFAVLLAPLQHEREVRDVMIRIQQAMIVPVV
LGDGRHLVAKVSVGYAMFPEQGLTADELLQHADSAMYQAKRQRREEVTDHKLSI
>A0A6P2FRF1|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. PBS-H4|TrEMBL
MAVLHTLGLIYGISVDAPVRELVGDAVAGGFILAGMGLSVMCRGSVRRWAVFFAMGAAAL
ASLGFGTTLVAHLWALIELMAVAMIVRAFSPGPVGRLTAAALGVLTAALLTTAVTDVPEL
WQVTFPICVVASSEIFGALLSAVTRAALLDPLTGVYNRTGAVMSAATLLKRFQRSGKLTG
VIILDIDNFKAINDTHGHRAGDKVLTQLTEQWTKLLPAESLLARLGGDEFLILTGATDLT
QVRQLARHLTQRARYQVSYGVSLGEGSPSSLPDLQDIADQDLYHNKKNPPTANRPDLQNI
PRNFPPE
>Q3Z0D6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWERELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLQLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A1V5BH10|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin035|TrEMBL
MCKTGTAGNHQNNDCFSLILVSTDFYSTPKDFWMCQVKDYVLDKVADLIKHNLLEGDNMA
HYRGDGFLILLPKVDSLTALKVADNIRRAVKKAKWPKGMGVTINAGVASYPEDGERLTEL
MKKVENAISQEKNK
>E2XC03|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDTVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>Q3Z2D4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MQHYFYYIHSKHITSCFIFVGDVLSCLQRLNNQHLPAVSWSCFVSDQIIARVSQSLAKEQ
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
KRAIDENCFFSDEVPDRWGDCIAARNLGISTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNPRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHSAPHC
>Q3Z2C4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQKLQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>Q3Z1N2|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A653JE17|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. 109|TrEMBL
MSENSGFHIQTVLILAIFALVFGLIHFFNKRQPFPGWVALAYSAALGAYIIDSTRHESTH
VGFIFASTGLFWMFSLAIIKAIYVRCNAAFPSVLVGLILSSAITAFVVLTFVAPDISIRS
VLVSVVAAILLALALPPLWKAGEKVIDGVLFGVIATVALIFVARIVVVYYLHGLSLTEQS
YSQSEYAWIFHFTSGICALALAVVLLYAAGLDMVWHFHGQSNRDPLTGLLNRRGLKALFN
ASADQHPNGDLTRAVILFDIDHFKRVNDEYGHAAGDKVLQRVAKTASGLCQEQAEVARTG
GEEFAILTGWIPFDSAQQLAQHICDSLRFVAHPELAADHKVTASFGLVALANGDSLNDAM
DRADQALYQAKRNGRNQVALAQAA
>A0A3S4WY65|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MISKHGLPGAVRLINLFLLVFFLSLVGIFSRPLDSLSLFWPVNAILLGVLLRKPAYAGPS
GWLVTYIAMIGADLTTGEGWMLALWLNLCNMSLVATGYGVMRLLPQAQRRMGSPQAILYL
FAASLAGAVVASTLSVLRNDSLYNNTVLIAWLAWFSEQFSTTLLILPVLLAAPRLKTLLR
MQYHWNLRDSLPLLALLGSLLFSIYIGGPGAIAFPVPALLWCAVRYQLFTVTLLALLTGV
VEICAISANVMLYETPASRGALLDTLMSARLGIAMLVMGPLILSSSMVANRKLVRRLEHS
GNHDFLTGTLTRSALTRKARELLEHKRRSKEAVSLLLIDIDHFKLINDTHGHIVGDRVLT
HVTHVLRRELRRDQPLGRLGGEEFAAVLPRALAAQAVALGEFLRQQVEKSEVNIGHKSLK
ITISVGVASLAMKEVKSWEQLMNMADIALYRAKSLGRNRVESFNAVSGSSVDHIWFKE
>G8AHU0|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALADAEAISGIFYAILLDRPDSNTFL
SHALVQERLRPSLARWIGALFTASSDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRII
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTNRISAKVTAAVEGGWITPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRTVEEHRFHGAGGAGNGLQVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A378IGW0|diguanylate cyclase|EC 2.7.7.65|Legionella birminghamensis|TrEMBL
MEKNHQIQDECFLLLLQSSLKAIPFNVFLSIIIWGYLIYRGAPISGASIWFLVIFILSVL
RWIYSRQCIKSKAYIHKKQSCLITFVVLTFLMGGLWGACYIIFYEHFSAFNQNIITLVLG
GMAAGGLASLSVYLPAYYAYLLPMFLPLVLYNYSFMILDKSILATMFVLFIVMLMITAKF
PSQLLKETIRLGKEKDSLISSLHNINREKDAALDEIHRISITDSLTGLYNRRYFDTRLNE
ELRRAKRNDHHCSLILMDVDDFKYINDTFGHPSGDLLLKRLAITIQNTANRANDASFRIG
GDEFAIILANSTAEEAMLICSKIQERFEAEATAHKATLSFGIVTIPPVPSNTEEIISTAD
KALYEAKKAGKNRIQSEKFAR
>A0A7U7GCJ8|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MKDLNNEYSGEVEEPEHPFSVLVVDDEPYIRAGVKQLLAAQGYQVAMAGSGEQAMTQLSE
NRYDLLVLDLGMPGVGGAAVLDFVAERCLDMAAIIISGTTSVMEATTALSKGAADYLRKP
FGPEELLDCVAKARRTLRQTRVGRRLQKFYDLPFVGMALSSPESKRWMKCNDRLCEILGY
PREELVNMTWVEMTHPDDLATNIAEFERVLRGDSEGYTIDKRFIRKDGVVVFTTLNAKCV
RHRDGTVDFFITTVDDITERKRVEEALQESEALNATVFNSLTEHVAVLDEQGVIVKVNAA
WERFAEENGAPALARHSVGLNYRSICLSAVGAFGGAAAASAWAGIEAVLRGTRDHFTLEY
PCDAPQVSRWFRMSVYPMAAPRRGVVIAHEDITERKQNDEWLRLCEARYGAIIEGQTDLI
CRFLPNGILTFVNDAYCHYFGRSREELLGANLMSLIPQEDQAGAAAKLAELNADHPSDIN
EHWVLRADGAVRWVQWRNRAILDEGQDLIELQSVGHDLTDQRQIEERLRESEEQFRLTFD
QSPIGAAIVSLDYRFLRVNDTLCQIIGYSADELVGMSFLQITHPDDLDADLAQARQLIAG
AIDRYEMDKRYIHKDGSTVWVRLAVRLLRDAAGQALYGLPTMQDITERKRMEAELREMST
TDFLTGLSNRRYFMARMAEELARLQRHDTQRAAVLMFDLDHFKRINDTYGHATGDVTLQH
FANLARGDLRKIDTMGRIGGEEFAIILPGADLVAALVFAERLRRKVAETPALMGDQPIPV
TVSIGIATMDATDTRVDAALIRADEALYRAKQGGRNQVVAW
>A0A4P8C3X5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:NM|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYCITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A7Z9BIB9|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MRYRIRKILYQAPFWTGGLMGLLIVGTIEVLKHWGFRVPVPFLFLGLTVMLCANLGGLNN
GLTCAGVISIYIIYAAWAQQFPTILILEPIQLSFVILLIFITAILLGRTTDKNNRLILTL
KTTQSELRQRLLELAEINALLDQENQERQQAETALQSLILETASVTGVEFFPALARQLSL
ALGVRYVIVTEVIPELPGRVRTLAFWGGDRFLENAEYDLDQTLCTQVYQTRSLTFYPDRV
QEIFPHILSLAELNVVAYIGLPLFGRSDKIIGHLCLLHDQPIKNEARTQSMIHIFAGRVA
AELERKQAEEAQKQAEAKYRSIFENAIEGIFQTTPDGYYLSANPALARIYGYDSPEELIQ
QLTNISEQLYVDPKQREEFCKIMTEQGQISGFQYQVYHKDGEVIWISENSHSVYDNHGNI
LYYEGTIEDITQRKQAEEKLLYNAFYDELTTLPNRSLFIDRLQQSLAHAQRRSDALFAVL
YIDLDRFKVINDSLGHAVGNQLLVELGQRLMNTVRDGDTVARLNGDEFAVLVEDIQDVQD
ATQIAERISMILAQPFQLEQQEVFTSASIGITFNFQSTGRLYESAEELLRDADTAMRHAK
YLGQGSPQLFDQRMQKNFRSRLQLETDLRRAIERKELLLNYQLIVSLVTGEIAGFEALAR
WNHPQRGLVSPVQFIPLAEETGLIVPIGEWVLKTACEQMRQWQLEHLINNTVTMSVNVAG
RQFSQLKLVNMIQEVLEETGLEAKNLRLEITEGVIMEHFESATTQLQELRDLGIQLSIDD
FGTGYSSLSRLQQFPIDILKIDRSFVSPLGSKVENREIVETIINLAVNLKMSVVAEGVET
LEQILELKQLGCHYGQGYFFSRPLDTEGIRQLILNHQFKYL
>A0A5P9C773|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSSIATPPVSPSRHRLKLSALITLVLAMALVTLGSLWLVQEQARQLALPTLHNELWQAYQ
IDNEMNHLLDAAHSLRKGELDSDDLVVRIQVLRSLTQSLERHHLFDFLPESQSITQGTLD
QIIGLSRDWDARARWGDPQGVRQLAEEIHQRLPQLLKPMHEVMVASKISLANKIDAKRQL
LHRCFIGLGWTLLGLLLGGALLVSRLVSDYRKARTLSHNLAELNQHLEQRVSERTAELSE
GQALLRQILDASPSDVALISDDGKQVHFVNQRLHQRLELDASSDFSLSRLFSNAREALHF
SEALQARQRLDGWETQLAGAEPYWGVVSGRVLEYHGRPALLIWSYDISLRKQMEQELLVL
ATTDALTGLNNRHAFLQRAGELFKSAERFDQPCTLLMLDIDHFKAINDNHGHQSGDEVLA
RLGELLRQVLREVDIIGRLGGEEFAALLTQTDRCDALQVAERLRLSAEALALNGADGQQL
GITLSVGLAERRPAEPLEGVLARADSALYRAKAEGRNRTAQAVD
>A0A6N3HZK3|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEEKYQAEIEKKRAESVNRAWKIISVFVVVFQLLMLILMAAKPGGPFKTQRRAIYCILYL
TLFLVTGIAMILNRNFWRREKKNYHLYLHAELVYAAFICFWGCCVTLNDQLGGNDLSVFT
YMMLSVAALGFLEPVKAGVIFMAAFVFLNICLPGIQTIENNIFSNIINSFSIAGISTAIS
YSLYRNKVIVTKQEVTIRKQYEEITRVNEILSHQAMVDELTDMNNRRYMEWFIGEKIKKL
EEESGTISCMMLDIDYFKQFNDRYGHIAGDVCLKKIAEIIRGCCQDNDVAAIRFGGEEFF
ICLFRWDRDEAVEMAETIRERIAECRFKINGEEEGAVTISIGVYTWHGEGKVQMDDLVCL
SDKALYQAKKNGRNRVEVLP
>A0A174ELZ2|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKKENSFSRNHVRTVILLVILVLAFIYLFLYDFSIRVDHLMTNMTTEHLADVNDQSQTAV
KTELTRVFEEVRYTADFLSETPELTEEARQRVYEQLKEKCGFANIRLVSADGGLYTVGHE
ALPKSVGGYVEGICRGESGMTDVFLSSVTGQEVFAFYAPVTREKTVEGGIAGIMIVDQMV
DMVTTNGFNSGSYSYVLKSDGTVIMQTSHADSLYSGRDYFSFLRSDTDMGVEAVSELQKK
MERKEKGVFLFTAANEKRIVYYAPAEINDWYVLTVVPYTVSNWYREHIGKTALYLTLKML
VLFLAQLAVIILWSRKARNIILDSKEALELEKKKLELALLHSTGTTFEYVPKDDSLSFIS
PPVVKEVEFPTVLNQISTKGAAVGLVAAEDLEKWKMILKRIAEGREPGPLEFAGGTSFSE
DTYFRLSVTPVRGGKGEVAKAIGTLEDITEERRIRRRFAQEEQYRAALLSEAVAMWSVDL
VRQQVMACTIHGKDWLEGGKGFLYSGRFIENMCRYIHPADHDRIAGQMQANRMLAAYYTG
EREQKELFRATYPGSEDYKWMTCTISLLTEPVSGNPVAFAYVRDVDEETKRKMELMYSSE
RDPLTGLYNRRNIEEKVEQALKNEDSLSCLIMLDLDGFKEINDKYGHQEGDAVLKKMARI
LSGAFRSDDFIARFGGDEFIVFLDHIPNCECASFRAEEVRRQVYALTLNGEERIVSISIG
IAFGPRDGNTFELLYKHADEALYMAKGRGKNQIAFYGEEEELMILERPD
>A0A165M426|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MTPNSHHRDRGTAAGALWAWFTQPYDYRWMADFQNSRPTGKLIRWVMAILTLNYGALAVV
ALFSDGATRNAAAIGWKAFLVVMAVAVAAAWIAKPFPGRLGVVAFAVFADLGTASSILVN
PIADAILTCALFAVIGTFCTFFVSPRWLVAHLIFSVACTVAAAAATYRTGDVDVASLIFR
TDVVLLAIAGVPLTSHLLVTVLTDDARSSLLDPLTGLLNRRGLESVIHDVWLLGREEDRC
SAVVVVDIDRFKAVNDDYGHEEGDAVIVRVAERLGAHMGRYGVIARTGGEEYLAVVSTSR
LHIDALIHGVRRAMRDPDDGVAVTVSVGAAILHASSPLWEQNVDLVTRAMRVADSMMYEA
KAAGGNRIVTTVL
>A0A649YPB1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MVVASESEKVIRRLYQITNDYQKGFDIQITQLIMMGLERFNLDIGILSRIDGELYTVLYC
VTSEGVELKPGDTFNYESTYCQITCSSFGPVSIEHMGESDEYAKHPAYEAFGLESYIGIP
IFVDDEVFGTLNFSSASPYPRKFKDIDVDALKLMASWIEVELIRRKQEERLRKLNSQLEY
QAYHDALTNVANRRCMFKTIHLDIERMKLASGKGSLAVIDIDNFKRVNDVYGHQIGDDVL
KKTAQQLQACLSERDFIARFGGEEFVVWLPERTELERRQLIEELHQSANEILLDGEPVTV
SIGVCEFDFGNESEIDNKKGALDQIILVADEALYQAKNQGRNRVVVRPLSEEPVTEMMSG
D
>A0A2X2ET74|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MTLSMPTLLVTNVYVLVLLGVLMLFAWARGSREATLGFLCVMLWSGALGLVIGSLRGRGM
DALPIVLGNVLVHVCYAMGWTAMRAFSGRRVFWSGVWAGSVLWLLACLIPAFYGSLAARI
QLSSLVIVSYTVLAGYELWRSRNENQVSLAALFSLFGLHSVFYVGRFFLDRSLPFARESH
GIDFAAFLLLETLLYSIGLTFAATAMVQQRTERRYRQASLTDSLTGIGNRRSFVEDSENM
LRHCQVQHSPVTLLLCDMDNFKQLNDRHGHQAGDQALVAFCEVARMRLRKRDVFGRLGGE
EFACLLPDTTTEAAYQMAERIRKEFASCSRVAGVSLSISIGVASSAEAGYVLDSLIALAD
KGLYEAKGLGKNRSVISQPV
>A0A6N8HSM5|diguanylate cyclase|EC 2.7.7.65|Lentibacillus sp. JNUCC-1|TrEMBL
MTQLMNFRMKIKALYFEISSMAQDSLTQTAYEKWVTELKHITESEKVVVYTYDPWEKCYK
KQTIDDENGSMMLYEIRAIKGETFSTAFKAAHPGNDFCVIEKSNLSDGIMLVLSKEGTAF
KQASWDTLVTETLCLIQLLLKHNQKERNHERMNFSFQLSTSLNGLRTKKNILAELKHALQ
KRYHTFDYELLLSQDYDTDDTFPVQLIPYTDQETRRMSTEAFMTGEMQSEYQEESGRPCL
YVPLTGEQGVYGVLKILGEKGKNIPEEECHFIAKALNVAGKAMEGAALYERTNRLVNDLK
WMNQVTHELNAGLDLKEIVSLMHDRTMEVSGASEVGVVFINEWHDQFHEIQSISTPYFHT
QQGRSFTSYIIKQIREKQESVFAGNLPDQTEVTHYCSVMAVPMMHNGAVEGAVIAVHEEA
YSFSLDTLKLFQSFIQHSSLAFSNALLKAELETAVITDYLTQLYTRSHVDEKVIEHMLTG
NGGALIFFDIDDFKTINDTYGHHIGDEVIIQIARIVESTIPKDSMACRWGGEEIAIYIPE
ADISDGLIVARDIRENIAHETEPAVTVSCGVASWEKDQTDSARDLFGRADQALYEAKETG
KNRIVLEHNKHLNC
>A0A649YY93|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MSFSLVTTNWFRLTFPVLLLAMIGFGMNNVINLTQANLGITSNLPYFLFFCVIGLGHAFK
QCRIAMVALTMLVVYWYIQEYLQSSLSTGSTLLELSLLAFVVPIACALVYPYKERGVLSR
AFIVYIVTLSLIAIWCYLILAYFYEGGFQNFDETFLYSEPSVSRLPLILVLYSVGAILLS
AIVVLRVNRIIDVVVYSAITLSSVTFTFFHVQYVSSTMFTLSGFLLLIYMLSASYELAFK
DRLTDIPGRLALESDLRHLGKRYTIAMLDIDHFKSFNDTYGHETGDDVLKLVASKMQRVG
GRAKVYRYGGEEFTVLFKNKDVDEALDHLELLRSSIEEYEMVVRNEKSRPKDDKSGAKKR
RKSNSHDHVNVTISIGVADHENADSVSEVMKCADAALYKAKRAGRNRIESA
>A0A6M8MST2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MLRPSAARLSHFLPSLALLIAGLAAAYVKDLNVFFTSLFNVLPTLVLLLGGAYCGVYKRQ
RELFLMITVYIAYFLLDTQTDYYRDNGKVREDAAVVFHLCCLLLPVMFGLFAAWEERTHL
FQDLVARVAVLVAVGSVALGLEQSFPAGLLAWLADIRWPALHGDWMSLIQLSYVTFFIAF
AVLITQYLYKPRPLHAAQLVGLLGMFWALPKTFILPFTLNIMCSQVMLMIAAAVAHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMSDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKITNGGGRAYRYGGEEFAIVFAGKTLEECMPHLEVIRETIASYQIQLRNQDNRPNDDLQ
GRQRRAGSQASAVSVTVSIGVAERLLEHRNPEEVLKSADQALYAAKGAGRNCVISHAQTS
KRGAVRMAAAG
>A0A7U9ILP7|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. AS-PWVM4|TrEMBL
MLMAQTPLPRQSGNPFLSVHLCFFAVFLFSAFLTVHEALELKTSYEDRQRAQLAEIQKNL
DSQFQESVDELVYYQKMLSYALTHPLDSDNAREAVTRFQALRQHPLWQLQLNSPRSMPLN
GVGDDWLARDPLLRRDPALIDQEIRAALEFSFIMQFSDPDHDFHSRFWYISRAGFYISSR
PPQSPQELEQSYATMVQRAYFRALNPQQNPSPYLRWTSGYQGQFDEGLMLTLSAPIISNG
YWYGVLSMDFPQARIRNLLAETRHTLLQGNLVFLDRKLEEVARLHAPDEVPLNAEQRQEL
LKRMQHERSGILRLGTQFASWSKLENVDGYIINVQTLKQGMKQELGRVTLFLLGMWLLFV
LMLALAHQVIFRLVRRQDELSARLTWRANYDGLTRLLNRSAFFEQFVAQATHCQQLQRPL
AVIQLDVDHFKKVNDTWGHHAGDQALIRVASVISHTLRKYDVAGRIGGEEFCIVLPETTL
AEASVVAERIRARLAAKTILVNASTTFNITLSAGVTSSEEQGDYDAESLQAKADSRLYLA
KTSGRNRVCSAD
>A0A732CXY2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 18:z10:z6|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0F9VB51|diguanylate cyclase|EC 2.7.7.65|marine sediment metagenome|TrEMBL
MVGWDMRYKDKHQLAAEWQALLERAPVALRQAVEMLVESRRAYFADHFYRIMLEDPHATL
FLSNDQVHKRLQPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQ
LKQALYEQINATFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNARTEEAYKLFSL
TQSIGDERERQRSALLNWENALMFAVAAQQATSALTRLASSEFGLWYHHKACHAFEGAPE
ITTISRHIRLIDEQWLAQLGDPDSQLRLTALSNIRDAARTILMLLDDILDRASGLEAGRD
SLTRLLNRKFLSVVLNREIELARRSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVAS
ILDRSTRGGDYVFRMGGEEFLIVLVDTDHDGSRLFAERLRQAVAKEPMLAAADILLNVTV
SVGVTLHDGHPDYHHSLQRADQALYQAKRNGRDQVIVC
>A0A7S6Z163|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MRLQGARLHARAWLLLAAVLICGTSWAQTYSFRDYAQADGLQGMTVNSLLEDRQGVVWVG
TELALHRFERERFTPVGKESGLDARYIRALGLDAAGRLWVSSANGLFVREGNDFVQVLRD
GKPIRADSGNVVAAYADGVVVVSENSLLRLSPSAAGGWSVHPLPLQLDDGRLLPAGRALL
ADGTALWASCGQHVCRIDAGGKITLLAENDGVPERQWRAIFRDRLGTLWLRGGGLVLSRA
AGEHVFRNRPAPAGTRFDTLSGATTLSEDAQGRLLTRSDRGLVRWEGDHWRYFGQSQGLQ
ISPMVGPLMMQSTGQLWIGTRGLGVQRWLGYGAIEHWDESQGLAEAPTWVSQRLPSGELL
VGGDAGSNVLDPRSGRMQPWTLENGQPLLQSISIALSPDDGAAWVARSSGAVARRDPRSG
KTTDVLQLDLPINRLMFDTAGTLWITTPRGLYRVQRGTPPRAERETALPAAFVGDIDLDP
QGRLWASTREGLFLQAKDGHWQRVQVRGDLPSQDFFLLDFSADGEVWLSLRDTGLWHGRL
QADGILTLAAVDDPLVARVMPFILRHDSRGRLWLGSSQGLDVYQNGRWARATRTEGLLWD
DMSANAFFEDTDGSVWLGSSRGLTHLLDPMRVFAAAPLRVDILHVRRGSQPLLPQARVAW
SRVPLDVELSTPGAEGGPDRVSFRYRVEGHQASWTSTSLSHLTYPLLPPGSYTLEVQAMD
AYQRSSSPITRFGFELVPPWWRGVPAIVGYVLLSIAAVIALLRWRTAKLLRRKRELEQLV
AKRTAELEQDKRDLEAARAELSLKATHDELTGLLNRAGILAALREMLLHAEHQGRPLAVV
LIDLDHFKLVNDQHGHLAGDAVLAGVGRRMDTLMRGDDRIGRYGGEELLALLPGLNLDAT
HRLDALHRGICGDYPIDGGWLHVTCSVGVAWFQRGETLEQLLARADAALYRAKRSGRNRV
DYDHVPLDTLDQV
>A0A428LL91|diguanylate cyclase|EC 2.7.7.65|Enterobacter huaxiensis|TrEMBL
METYLKTVKDEWMQLITETDPHVHQIAAELAQVHAPALIGEFYRVVLADPNVAEFLTTEQ
VERQLREALCRWLVDVLSCSTDQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PLITGIPHSSEVKLKLYHYAVNSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMTLLYKVILNSSIGNSLPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQELDDAFNAIRLSDQGIGNKPLRVKFLQQTRNTLSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREIIHATRAGTSLSTLLIDVDKFKQINDTWGHNTGDDILRKVSGVF
YDHVRTCDYVFRYGGDEFLIVLTELNEADSLRIAERIRRRVEKIKVTSPDGDLIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKATL
>I6CIM3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEI
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A0S4X4J9|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum|TrEMBL
MALADALAGVLRPHDLFGRLGGDEFAVLLPDCDLATALSVVDRLKAAVAVHRHPVGPLTV
SVGAAPLRPGQELAHLLADADLALIEAKRRGRNRVCVPSGCANDAAGMAGIAASVG
>A0A1M7YVZ8|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MLVPKQPDNEDDRLSALQRLDVLDTAPEERFDRITRLARRLFDVPIALVSLVDENRQWFK
SCIGLDASETSRDISFCGHAILENKPFVVPDASKDPRFSDNPLVTDAPHIRFYAGVPLHY
QDCKNGTCHLGTLCIIDQKPKHITQAELNDLIDLAHLAEREFSASHIASIDELTQIQNRR
GFISLAQKASSYCQRENRPFSLAYIDLNQFKPINDQFGHAEGDKALQIFAQLMQQSFRES
DIIARIGGDEFVVFMTGIAQTDAQTAIDRFRIQVNRHNQEANRGYEMTFCEGIISVEPYR
HETIESLLCEADKLMYKKKKK
>A0A7U9XPT3|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKDLVLHLGNVHHLKNICYLGSTVQATSNAMRRQVFMDGMDALSLPYEGRIFSCSFAETD
ISQTLDRILELTPAPEAIVCYNDKIALCVISLLKERGYHIPEQIAITGCDTLEFGQMTAP
LLTSVTFPIDQVGATAVEQIFQLSRQTPARCENQPDDNTKNDTPLPVTTVYAAPSYKTSC
GCPCSQNVFSYSYAKKLDQRIADLEENLILNMHMSANLQDVEDIDSGMDVLAGFVQSLEG
CREFYLCLYEDWDRVSGHIRELTLTDENDIDSDTVLLKLAVRDGKRLPECTFTKRNTLPD
YLYDKGAYSYIYAPLFFGEKSFGYIALSFDHDRIGYSFSFISWLLNVNNMLKSLCDKKNL
GLLVGRLEDIYAKDELTGLLNRQGFKLLAAPVFEQAIADRQPVAAFMFDLDGLKQINDAF
GHGEGNFAIQVLAHALESSAGETDICSRSGGDQFQILAPDCNASKAAWLIENVHKYLDNY
NKLHTKEYAIQTSCGFCVQIPRSPCELVEMFEAADKRMYEDKHNKRCHTS
>A0A8F8G890|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MNPPAVMYFALIAPACVSLFGFALLTCWYVQRRQPQAVFLLWFFGGFIALSTALAAQSLM
TNSQLTQSALATACLYLMGFWLLAQGMSLRLRGRGVSVICGLVIGLVGLAVVFYYTQFES
DRRIRIQSLAITMALMQALALPAFLQAKPAQDWVEHLVRGTYVVNVVYALFRPFAVNWVP
MDEAHELTRSGYWALVQATALLFSMLFTVGLIACSVRDMVTNLRDERNRDPLTRLLNRRA
FMEAAQPLLADRRQAPWALVAVDIDHFKRINDNWGHAAGDQVLVQLGPLLLKQVREKDLI
ARFGGEEFMLLLNRVQMSEAHAIVDRMREQMKTQEFDHLPERLRMTASFGIVPMGSVEEL
AGALSQADDLLYEAKRSGRDCVQTLKTADQGFDEAVYAIDLRAKSAVYS
>A0A245ZH14|diguanylate cyclase|EC 2.7.7.65|Sphingomonas mucosissima|TrEMBL
MHGHSYAKLGTAGLALRWLFEPGGYVDPRGRAFLLAHLLDSTTAVIMGSFGAIVIASAAL
LRTGDQVYAIFCALELALMAARLFEWRVRTARMRNTPDYVPSVDRSVLLSTAWCVLQGAM
AFKIMSSGDLVLSVLSTALAVGTLGPICARNYPAPRLAFLLVLMCDLPFVAGAVASREPW
LLPIVVLTPMFLIGAMQIIRAFHRSMLLLIAAEARALHLAEHDALTGILNRHGMDSALSR
ITPSTHRSMALLSIDLDGFKQVNDRHGHGAGDVLLIQVAERLASQLRAEDLLARVGGDEF
MVVVRDIGAERAAPLVERLIEAIAGAPYEIGDGSLVQVGASIGFACLPEDAAGTVELRTR
ADLALYAAKGAGKGVGQRYRPQL
>A0A4V0Z737|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MQKIFTRYISYVVAAALLAILVLNWGLQGRNARSQMIQNSALKLGQISQTIDNNEVELQN
LKESLSEDYLTRAYAFAYIIQQNPSVLESQQEMERIAELLNVDELHVIDENGILFAGSIS
KYFGMDFHTTDQTKEFLSILDDPDSYLVQDIRPNGYEEKVFQYIGVARQDKKGIVQVGMA
PTRMLEAQKRNQLDYIFSRVPVDAGGVLFAIDKDSGEVLAHSDEKMAGSSMEDLGLSEKE
IADCRDGGFIRQDGEKIFCVIQEKGNLILGAGANEDQLYDERNTQTILTFCYLLLVYLVT
ILVINRLLKHQIVDGMHTIMDDLNEITDGNLDTVVKVDSNPEFRQLSQGINKMVQGILDA
TVKISKVIDTLDLPIGVFEFNEDNERVMATERIRLVLDWSAEEMDQACRDRKVFREMLEK
TLRAALDKRGSDFKIRENPEKWVRIFTTTENGSTFGIISDVTGEVQEKKRLEHERDYDSL
TGLCNLDTFRKEVENILEARDIGECAMVMLDLDSFKGINDRFGHDWGDEYLRVCAGFLTE
FNGEHGLAARRSGDEFCLFLHHYKTKQEIANDMEEFYSCLQQNPVIFPDQSRKTLEISSG
LAWYGGGLNEFQTLLKAADYALYDAKNSGKGIMKQYSLN
>A0A411ZGB0|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MSSEPLSQSFALREEIDAALSDERSYDAWSKELREAHKDHKTERVYQNLRFQLVTGFGIS
VVTLLFDFLVLPELFGFAVGWRMITILPLTLAGLFLFKPDQISSIKLFAGLSLITFGMQA
MALASFSPHEIMVRYSMATTLLMGIAMFALPFTPNELRRFGLGFALATSLVTFWPNPLPT
HDAMMYMSFTALVGIPSWYIAKRHWELNVRAFLLDLRDEFTRVELEQNNELLRQLSEQDP
LTGMANRRHFERVCSEGLASTERKHDGKIALMMIDLDHFKAFNDRHGHQAGDRCLTMVGA
QLQQVFGERRGIVARYGGEEFVAALQERTPGEAEALAEDLRAAIAGMLVPIRDEASPLIT
TSIGMALAPSDTQLALDDLIEMADVALYSAKRAGRNRVEMIETGSATVSFTGANDTRQRA
>A0A5P9KN87|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. Bb-A|TrEMBL
MTDVAEHDLTAEIARLRAELDAWKQRAAAAEAAADHDVLTPALNRRGFVAALQRAMAYCQ
RHEVPAVLLYLDMDGFKGVNDRLGHAAGDAALVAVARMMIGHLRESDAVGRLGGDEFALL
MLNAGQEDGRAKARQLAEALETEGFVWNGERTPLGGSFGVRAWDGHTDAEVWLTEADAAM
WVRKKGR
>K1KU52|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MFSLRNIVKLKYLFISVIALAFVLSTLVGVYSTYKGNMKLMQEQTLENNRVYALKLAETV
DKFIANSTNTLSYSATEIANNFNNINKLQEEVNRLYLRGDTFSSVLIVDAEENALVNAPQ
TLGEAGKNSPFLKELKNYDKYKPFISDPFISPTGRKLIVISMPIYDEQGAFKGVLSGYIY
LYESNIFESILGQHPYENGSYVYVVDTRGKIIYHPNKARLGADASENEVVARLLNEKHGA
LTFVNTLDQPMLSGFSQSERTRWGIIVQTPYDAALSMVGQQVVSVLKIGLPFIILSTIVV
FLLASQIVRPLERIAEISENSVKEQEMKKLKEIRAWYYEVYKIQEALIHSFSFLHGKVNT
LKEETSIDSLTNLLNRATLEKKIQLLTEQRKDYTLVMLDVDWFKSINDTHGHIVGDKVLQ
ALASKLKESLKENELACRYGGEEFIVVFTETTVEEAYERVELLRGNVQQIISPAGKPLTF
SAGIANYPLHGVQMKNIIGKADEALYKAKENGRNRVEVTKV
>A0A7U9T1E2|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MGMRKSLSQIMGDLQGAFVHSTGYIRRDSLKIRKQVQEKLAETNCKRILAVAPGLILIAV
YNMASLNSARAGELFPVSLSLSIWIIVQAVLFAAIIVWILYLNGIDNSKEVWKCKILHRV
FWWSWFLGMAGIALCRVECGRGYDFFVIICVVLCIVPLHSFWEFCLLLGLAYMVFVWSAS
LADRMGVDYQAFAAVMYAGIALLVVGFVAQQFEVGLRTLQEYIQVKTFIDPLTGLLNRRG
ANAVLEEELSGGRRHPFLGVVMLDIDYFKKYNDSLGHDAGDECLASVADCVRDAAGDHTR
LLIRHGGEEFVAIFPGVYGRELEELAEKIRRTVFDRGIPAPASAVSKVVTVSAGAAAERM
PEVSADRELRYEDLLRRADEALYAAKAAGRNRVVFSEDSVENG
>A0A5P9HDV6|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MRQARMWLTAATLLCLAALWAGSAMAASRDLGAGWEYRWGDSPMTADGVPTWARPSDDTA
WQAIDFPANPPGRRGQTHAWFRTVLPDGDWRDPVLYITSIDLIAEAYLDGERLYHHGTFD
AAGNGRFAGWPWHMIRLPEDFAGRLLTLRVYSDYTDIGLWGEVRLMERAELYDLLLRDSL
DALIVGPLCLLLALLAGGFALFQDDRRRFLPIGLFALGSGVMILAECPASQLLIDRPLLW
DGLTAAGYFSLPVALGLLLEHWFADTRARRIRRIWQAHLLYLVGALGASGLGWVELSMTF
PVFDALLVVSLVLLLAIIVPYLGRFDARQRAILGAFALFGALLLIDMAVAHGLLPWRRVP
TSAGALAFALVIAGISLIDYAHTQRELKRLNRQLEQEVEERTQRLQQLVDRLEIDSTTDP
LTGLHNRRHFDECLRQETHRARTRQAPLALAMLDIDHFKRINDSHGHAAGDRILAGVAIA
LREHFRDDDEICRIGGEEFVVLLPGAGADTARERAASLMAGLADRVYWHDGHMLGPVTLS
CGIAAYPAHTDDPLALPDLADRALYGAKKTGRNRIITAT
>A0A5P9KRV8|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. Bb-A|TrEMBL
MTAELETTVRGPQAYAFAHHVIDEMEKAGVWPTRLNFELWLHYLDDRESPLACEIDRLLA
ASAIISDEVSERLAAEFLPRGRLSEQIRDAGAVLDRELASVANAIAKAHKTQADYGDTLA
DASNTIEAAGAASPLKALVGGLSTATKRARRETAVLEKRLETSNKEIARLREHLEEVRRE
AMTDALTSLANRKAFDERLEQSCASGDAPLILAIIDIDHFKRFNDTWGHQTGDQVLRYVS
TVLSRFSGGNRFVARFGGEEFAILFPGEGAGTVLAALETIREEVASRALRRRSTNDDLGK
VTLSAGFADYRPGESPAALLERADAALYASKRGGRNRVTRAPALENAA
>A0A3B9IF57|diguanylate cyclase|EC 2.7.7.65|Tistrella mobilis|TrEMBL
MPTTAGKTAARHDTAADPNPSLTAARRDWHRLQAALAPEMRDWLAGLVAASSDELARDFY
DVLMADPEAAPLLSNEIVQTRLRGSLAGWIRSLFPAGPAPDFESMAIVQTRVGEVHARVR
VPLHLVSRGARLIKAGIAGRIAGSRVGRDELVRLLLHVETVIDIAIELMGAVFVSGITHQ
SRDEEAYRLFFLSQDLSLERESQRASLLEWNQAVLLALAGGSGSTEPLPRIGRSDFGLWF
HHRGGIMFDGTPVLDRVNELMQRLDEGILPETDAARAAGNGFGPALGPIQNAVNEIRFIL
NDAFQALIGAEAGRDALTRTLNRRFLPAILKREITLAMRRDHPFAVIMVDLDHFKTINDS
HGHSAGDAALRQAAETILGTCRSSDLVFRYGGEEFLVVAVEAGEAAARALAERLREAIGK
TEVVLSGDTRIRLGASVGVAVFDGHPDYNHLVEAADSAMYQAKRAGRNRVVVAGGR
>A0A5E0ZVL8|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MRSDPAAFTLFRPESPLRNAAGIFILTTLFYFIGAELRLVEALSLFWPLNGVMAGVFARY
TYLNRLHNYAVSYVAMLMYDAVTTNWGMASVVINLSNMVFIVVVALLVVRDKRLMKKTPD
PINALRLFNYCLFAALLCALLGATGSVGIDSHTFWPLFADWFSEQFSTGVLILPCMLTVS
MPTRAFRLRLEQLLPVIALIVSVMASVVIGGAGSLAFPLPALIWCAVRYSLPATCLLTFL
TGGLEIVLVANSIINIAVGTPLSTPMMFSARLGIATMAICPVMVSVSMAAINSLIRQVSL
RADYDFLTHVYSRSGLYEALKREEAQRQTRFLTVMLLDIDYFKSINDNYGHECGDRVLAA
FAREVQQVVGDDGMVARMGGEEFAVVVNTGDAQHGFALAERIRLTIAAHPFTWRQQTLYL
TVSIGLGSGKAASWQLTEVFNRLMAEADDHLYRSKKAGRNRTSARVSDDPITPTPEGET
>A0A7U9SFJ1|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MDTYYRITSFPMEWKERSSYVHVVVDITEEKRNARNLASEEYHDPNTGISNRMFFEEYMR
IVLRDDQEATLSYLCVDGLEEVNERFGHQEGDEYIQNFVEIVKKNFRGGDTFARIGGNDF
CLVLTGNMEELINRKLTSILKEFQEETYRKYRCSFSYGIVEVMGKDNDMSLDEILQEAKE
GMLECRERNLAKYPSLCAE
>A0A5B8R095|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MAKSIDFDQALNELDVLLQSDLSTAQKKLAEYETAFSSLTPTQKGRLRIDRAISYIFVSE
YAKALDDLHQAETLITNSELLASVYSYKATVYIGMRDYDKALSAVAKALALVVNIDDVAI
KRHSYLRIANIYSEMDAYSDMGLYANKVLQLAQETDVRDICHAKLLRAIYLLGVKNPDAF
DAFEDSRQYCDAKQFPLLAIISMKGKGMVLQERGDYLGARAILLLALKGYEAFQFQLEIS
HVHALLAENYFATGELVQAKSHAVKVLTFPDDNSYIEHKHIAYKVFAELMAADKQFEQAY
EYSRKEQHYNQLIFDESRMKTLAYQAAKFNADEQAREINLLNKERELYIAQQMVKEREYT
NMLMFITILVGGLFFLAILLVVGNLQKRRFMRMARMDALTGVLNRGAGQDLGENLFVQAA
ARGGDYCVILFDLDHFKRINDSYGHGTGDWALKKVVEVLKPHVRNGDVFARIGGEEFALF
LPYANESKGMEVAEQCRSRIEAIDTHLSGHKFTITASFGVSGMTTEDLSLDPLLHRADMA
LYAAKSNGRNSVFCYEDALASDKRATNITSQFARQ
>A0A410NUE3|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MPNPTSAVATPSCVSEPSLDPQSLERLRALLNANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRRWLIDLFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDAAAFGLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRASLMEWSQKTLFRILASGGVDGAGALGASPFGLWIRHRADFLFDGSPHLTRLNATME
RIDTELLPRFTPDAAPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHR
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGA
>A0A1V6BZ24|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin133|TrEMBL
MEKKRILRIKVIIIGVLVIALFCIFSISLYSNLIIYSKKSKKFFLNDFFSNGKKDNLTYQ
IKSNDARETIVYKMEIPKKEFDRINSENYKIVIYRIASHWYKVYFNGILIGSVGNLENDS
SIVWNTINYFDIDKNLIKDINEISIEIYYTYEIGALSFPPIITDVKEANRLMNWFKFVLS
NIYIIAIGIMWFSFLLLMILSNLMKNPKKEYLYYSLATLLFSFYIFDNILIYDMIFSTII
FKKIIFSCLYLSVSFVSLAIYREFKGKINLISIVLILFSAIVIIFFSNNMVLLKKMAGIF
NILIILNILGWIYSTFKNLKISNDAKVIFSASIFLMIVTTYDIFFMVFGKTGIYNTISTN
ILGSIFFSLVIIVLVVFDYIELYSKMSWEKERADLFYEKSSRDSLTGVYNRQYVESYIEN
LTPPFSLLMIDTDRFKEINDTYGHLVGDEIIKYIARESVNNVRSGDVVARWGGDEFVIAL
KHRGEKDNSLYVAEKVRNAIKKTYTIDGLNFNVTLSMGLYTVESKEENKIIFKKADDALY
ISKENGRDRITVWKENMRSV
>A0A679KIE3|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MSHGSYGDRERTFALADRANVLMRDYGSSATPQAYAVWYTYVSGTQPLMNDAIKGLTTEN
GSLSDADIDSLYETYIDSRRLVAATERMNANMLAEIEGIMEVMDLSLGSTAQYGESLQAL
SHDLDVSDQNRARVREIITTLVSTTREITASNRTLEARMRESRNEIETLRETLEATRLES
LTDPLTGLSNRKHFEESLRKMVDGAASQAIPSSLIVIDVDFFKRFNDVYGHLTGDQVLRL
VAIVMREHLKARVTLARFGGEEFGILLPETNRAAAVAIGEKVRASVMGRELVKRTTGESL
GKVTISLGVATSRPGDTAVSLLERADQCMFMAKRDGRNRTVDDSRVALEALTAVA
>A0A6J4FRT6|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
METSTRILVVEDSKFFSNIVKKSVIERTGATVVTALSLAETKAAVERADAPFNLALVDVI
LPDCQEGEAIDWLLKQGVPCIVFTGVFSDDLRERLLAQNVIDYVVKGNPSSLEHLMRLVE
RIHRNRDTKILVVDDSKTARHYLVDLLTSYQFQVVTAENGREGLAALDADPGIRMVITDY
HMPEMDGVEMVKRIRQNYDQDRLAIIGISSGGGNALSARFIKFGANDYINKPFLREEFFC
RVTQNIQMLELVQRLSDMATKDALTGIHNRRFLFEAGESLFANAKRSHLTLTAAMLDVDF
FKKVNDTYGHDGGDVVLKRVAARLRSQCRQTDIVARFGGEEFAILSVNMDADSIEPFFES
LRKAIEDEVISLGLQRIKVTASFGVCATTGTNLAEMLKTADEMLYRAKANGRNRVEIAGL
ADPTLQTTAAS
>A0A376EI75|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MKSASEQLNRHQHSSALRFVRRMFFMRQLGTTLCFIPLFALLLELQRPLWTQALLAANAF
VWPLVARYRARRSRHPARTELQNLLADAAAGGFWIAQTALSPLTSVAIATILLSDRLSAG
GFPLMRQAAGVMALMFGATWLLLGLPVHLAVSSRTLYATLPLIAIYVLALSVVSHALSTR
LRQKTRELERFANTDPLLNIANRRRLEHDIDAALRRFHTREQPAALMFIDIDDFKAANDR
YGHEAGDRLLVTFAEILREATRAGDTVARFGGDEFVVLLPDTAFGRACAVGDRIMAQAAQ
MDVFPDSAQRCTLSIGIARHGGHAERGAVAESRGRRALQRQARR
>A0A2U3LVL0|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MFYLDRNIINSISEIVAYFLIVVIMSNNFLSLKLRKIYFLVIFYFIGIGILVSTGTMGAG
MVCILFTMILSGCLLERREIRVGVLVNLFVFLVLTHLVMGGYIYNVGLLDYKRVWFINAI
TTQACGIAALIIMNTIFSGLENQIKVIIAKEEEVYQLAFNDHLTGLPNRRLFYDRLGQAI
LHAARNEQSFEILFLDLDGFKMINDTMGHAMGDELLKKVAERLSNTLRNNDVIARVGGDE
FLILIHNAPNKESIEKVCKNIINVIKEPFEFPTNEIYITTSIGVSIYPQDGDNVETLVKN
ADIAMYVAKENGKGKYAFCNELMKKNLDEVMMLSNDLYRALESNELEIYYQPQVDSRSGS
IIGMEALLRWNHPKLGLIGPCDFIPIAEKTGLIVSIGEWVLRTACTQTKAWQDSGFPNLS
IAVNLSVNQISSRKLVNQVSKILIETGISPKYLELEITESIFMKDISAIVDTLKELKSLE
IRIAIDDFGTDYSSLSYLKKLPLDRIKIAKTFIDGINLNHIDESIISAIIVLGKRLGLDL
IAEGVETEGQLQFLQTQMCDEIQGYYFYRPMPVQEIDKLFQMGNKHNF
>A0A6N3R4J1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFS
LLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIA
EVGISPV
>K9NLA7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MEKAGGKGFSLARRLYTSRILGVALGLVCVSAAMYPLDPAPWVWGFMWFNGLVWPHVAYQ
WARRARKPYHAEHRNLLIDAFLGGFWIAAMHFNPLPSATTISMMAMNNVAIGGMRFLLAG
TAAQVLGIGVGLQIFAPAFIPATSPLQLYACLPLLCLYPLALGWICFRQAHTLGRQKREL
LALSRTDSLTGLFNHGTWKDQLEVEFQRCKRQQKGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNRAAMVMDALRDRFATLGYEQSPA
LKVSLSIGLASFDPTHTDATLWLNDADHALYEAKTTGRNRVICCGNGKPHRELLDSA
>A0A399F1T3|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MSDVHSKLPEAELLAGALEPMAMLDERGRVLAWNPAAESTFGYSQAEALCQALSDLTAIP
LPAEQLAELAVAAGSVRQVEGRARDGRSLVLELSLRPYRKDDLTLYLACLRDRTPLHQAQ
QQVQALQAETERLAAQRTTLEASLRESAYLAALTGALERYEDLQPLAGEVVRRLRPLVGA
DWMAVLLGSLKEGFSPIAFDGQAPQLLRFLTEQPLALGLDDSLPLELAHSQPRFVDDYRS
LAITHPACLQSGVASVAWVPFGTPEQEFGLLGAFRLQSPRPWRLEEQGLLEVTADALSIS
AQRVTRARQLREAAQYSEVLLQISRLAETTLEVEEAAAKVIRTIANVADVDWIGLAVVRG
NSVGLRKVWDSPMSIPTADMHKEVSPVWEAIEAGNPVYIDDYPSYPRAMAALLEVGVQSV
AIIPLTLGERGMAIFAAKFGSDRPWTHKDRSLFEAAARSVRTAQEHRDYLRAVEAAAFTD
ALTGLGNRRAFDRDLDASLNSAQRHGYPVSLLMLDLDGLKQVNDTQGHERGDALLREFAR
ALVATLRREDRVYRLGGDEYAAILEHTPSGESTFSAIRSRVAQAIAELRGNGFPQADVSA
GLAAFPQEAGDAQSLVRLADERMYEEKAIHRARRAHPNS
>A0A2H6FMQ4|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin08|TrEMBL
MEERRRIEEELKRSEERYRSIIETDPECVLILAPDGKLLEMNPAGLAMIEADSFEQVAGR
PVYPLIAPQHRDAFRELVERVCSGDTGVLEFEMIGLKGTLRWLEIHAVPLRDGGERITGL
LAVTRDITDRKRTEKELSQEKAFTDAVINSLPGIFYVYEEGQRLIKWNRTLETRTGYSPD
ELLNKHALDWFAEEERERIATEINNVMGKGESTVEANLVLKDGARVPYVLTGTRLRSEGR
NYLIGIGIETTKLRQVEEELRKAEQEWSNTFDSISDFVSVHDREFRIVKANKALVDFLGI
ALEELIGRRCYEVFHGTDRPLLNCPYIESMRLKKTVTAEVEYTKLGIPLLVTSSPLFNGD
GDLIGDVHFAKDVSGIKAAEEQIRRKSEELSVLNQITRRSQEFLRIDEFIETALEAVSSF
LGPDITMFYLFENGKLHLKGHRPEEEGGVVEEKELGVCLCGIAAMEKEPVYSTDIHRDAR
CTLGECKRAGVSSFAAISLRRGDELLGLIGLAWKEKWSFDEGEKGFFETLGAGLSLALHN
SKLYEEVRQHAGALEIKVEERTEELQKIINLMAGREVRMEELKEVIRQLREQIETAGFTP
VADDPLREG
>A0A378JE11|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MKQKTQNKIDKESFFVLLKGTLVSIPFNVIGAALLSLDFLYHNVANRIVFSWFGAILFLS
IGRLIFNRVVIVKKYYQTHFDLTLFLFLVFIFVTGLTWSAAFFIFLPITNSTQQAILALV
LGGLSAGAIASLAIYLAAFYAYVLPMLVPIIIYNLYLLQPDKVITGILYSMFLIMVCITA
RVSSGLLHTTFKLGREKDILIKELKLSNLKLEKSIEEARAMSITDSLTGLYNRRYFDMIF
HNEFKKAQRNQYAINLVLIDIDNFKYINDTFGHPSGDDFLIYVANSLKISAKRANDIVFR
LGGDEFALILSNMRPTEVLLFCDALQQRFSNNNQYTNVTMSMGIISIASFHSLDLQTVIS
AADQTLYQAKKDGKNKIIAKVIN
>A0A447Q9X9|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MAVLLLAYAWLSNMAIGIALLGLLLALTGMRWRLARVTPPVWPNAMLVTVLLWSGLVGAI
ALLAMLSGRMVLILFAGLLITALAFWLMQRHAAAPRFALLEIMLLTLPYLLAAPLSRVQN
LFLLANLIPLWLLLAHGLIALYHRQLVQYVTLAGEKRKAAHRDHLTGFLNRTGGETVMQD
ICRPSATVHPLSHLFILEFTPLAALYQSHGVLIGDDVLRTIGERLKMLIRPSDFVCRYTG
GQFLILVHDLPYGSEGEFLARIMPPLEAPYVFGAFGEVTLQLNAGVLALTQDFQTVDNLM
AAAQQALAINTKE
>A0A518EUZ6|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Poly30|TrEMBL
MGKIEKVSGYGRFLGPADGSPGMGLGYLPGMSARPRRLRPMRLLIADLPTASVGPAGTFD
GEPIGSPPSADSGRSRSPSPELARVFRPLEALGVELVVTETAQATEDALQSKPFDILVID
ARAFGKGAARPWDRRARSGARKNGAIPILLVADPDDPIPAVVAGRALRGSQWDLVHRDAP
PEELLLRTERIMDQVQLLDDLERARYHASHDDRTGLLRPLRFDARLREHFSAAQRHRLEL
ALVLVDLDRFGEVNKAYDHTVGDELIARAGSVIRMSLRTEDVGARIGGDEFALILPYTQR
VDAARVVTRLAGRFRALSGPPPQRYHGRSDEGQEDLLARSSGGSIAVSASIGFETFDGTD
LRSPEELRQRAERALRSAKERGGNQGIYYRSLEEEEEWAPKILHPQPPPAPLTYTASLGN
FPVSGDARLFRSEDLKGGEPKRSDHEDERLDAFDD
>A0A0L0APV1|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RIT-PI-d|TrEMBL
MEKTQWLSKFGLRFTPGQVVSLCFIVVLICSSFLTWREVAVLEDSYINSQRNRLESVSHG
MDMQLQFNMDRLFFLRNGMQAALKTPLQLQSTYNARRQFEVKRQQDVWSLQSSTRHLLTA
HGVSDRFVENAADLNRDGALLHNELTSALELGYLLHLSSSSNSIELRTQYVSRAGFFVTS
DPAEIADIAAYYTDLIARPWFFTQSIRENRGRGIRWYTEQRQEQGSQVITASIPLDMSGQ
WYGVLAMDISVSALQRLLLEAIGAQKEGAWQLYDSQLTWLTSSATGEGQRSPLSAAERQH
IIKALENDTRGGMFTSTRYISWQKLKNFDGIVLHIHTLREALGGAFGNIIIALTLLWLVF
TFILILSWIVLLRMVRNMIAMQESLKWQAWYDALTRLPNRGALFDRAEMMVRACQQAQQP
LCIIQLDLDHFKSINDRFGHQAGDRVLSHVGTLIATALRENDIAGRVGGEEFCIVLPGTT
AATGAKIAERIRKRICAKELLIRKNTTLRVSASLGISSTEEDGRYEFEYLQSIADRRLYL
AKQNGRNRVYSEG
>A0A238D9W9|diguanylate cyclase|EC 2.7.7.65|Thiomonas delicata|TrEMBL
MRGAPKMNELYPHVDISMIRRLAGERDFSKFFELAATEAARAVQADGAALIQHAGDNRLQ
YRFFQGLPADYQKLASSFTFSSESGTAGVALRTGSPIFTQNYKESPYAIPEFIETGIQAN
FVIPIGPEDDRRAVMAIAWFKSKPIQPPNATQLAIVQLLSDLIYAALYRQSLEENLAQQA
QHDALTGLPNRRYLLDHLGKILNQSQENRDHMAVAILDLDGFKPVNDTYGHAAGDQVLKQ
LAARMVTVARDVDFIARLGGDEFAFVFGSVQGKACLENLLDRICAILEKPYILSDGNSVE
CPSSLGVILVPEHETDAETLLRHADRAMYVAKGRKKIIDTPWEIFKSESLSHASRSSQDL
GALFSSQLELHYQPVFDISRKCVVRLEALARLRDGDRLTMPSNFIPSLNQRQRRKLFDAV
LEGVLNQVQKWKIENDCITSISINVEPLTLVDSQLPQRIYNGLNLYDVEPHQITLEILEQ
GEFLSQKAAIRQLTELRAMGIRLAIDDLGAAYSSLLRLRNFPIDEVKLDQAFVRELSSNL
KDIAFVLSVRELARGLAVDLVAEGAETPEVINILQALGINQIQGYGIAMPQQPSDVPNLL
HQLNSWENPPQKNIFAVAYTKHLTMDSNIIGLLLSSPRHLNAETLSGQISSALGGILACI
PEAFSLYRKQLVLLHDMARHHDTDLRLPIKRYQELGSQLRHVLHEAARME
>A0A4R0FZ10|diguanylate cyclase|EC 2.7.7.65|Enterobacter quasihormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNASPLVAEFYRVVLADPSVAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHTPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQDLNDKVHRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTMLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDTLRIAERIRKRVEKIKVNSPTGEIIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A3S5D9I0|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MTFVAIDCDKLKVINDTHGHQEGDRIITLLAKAIKTSIRKSDYAIRLGGDEFCIILVDYA
AELAMHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQASDAQLYLNKQQKQHR
S
>A0A3E2YVG7|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MW-13|TrEMBL
MGWLDRVNDQVDVLTRARDLQEVDRSAEACVLLDGVVHSTANPYVRADALVQRLSALINL
GRTAEFTRAIEEASNAVRDLPEPYLHGHVNALAALAAHHQGALDRCVTHLVKAARALGAV
DDPDRDTAWGWHDLAMAYSYLSFHGYALGAIERARQLGVAAGIPEETFAAPGIRLRNAVA
LDHNGDSDGCLRVLRDVASDLGRFLRGERAGQLRPSSLAAYGYAAARRAALGDRVETGTD
ADPTRLLAHGGDSARARDLRQLGQVCLAVAAGNPIEAVTRLDNARVSHETLGAAEPARLR
SIAYARAGDHPAAHRADRHAFRLAAQRNDRLRDVYIDGIAARIDHEEMRREAARYEGEAL
TDPLTGLPNRRRLERYIAAVVARGERVVIGVCDLDGFKAVNTRHGHHSGDLVLQRVAGVI
NRVMRRGDFVARYGGDEFVVVLSGAGMAEAAEVARRIEAAVRTEDWESLVPGAPVGVSIG
FAEVTGSGPGLRDALGTAFETADREMLAAKTRPRAS
>A0A828U9A2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli DEC2D|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A556UHR7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus campinensis|TrEMBL
MPWRKLVPRPRWLPRAAVMRPQRVVIWCFSLVLALTLAVGLRDLYTLRERVIASHQHNLA
LRAMGLEAAVSSERFRLSFVRDYARQLMRMEAVPAVGVSDPAIERAFAARNAPIWQMEVP
LGDAPVVGVSPQTLAGLPGFERRVDDLRADLFAARQLSHVLGLTMGVDEIRNSVTFISSN
GFFVTYPAVPADKAPALLQRFASMPYYRDLLPDRNPGQQLRWAPPYRQFESTELRTTLSV
PIYVEARFRGVVAVDVSLKHIQALLGAPSDDSPALNRYLMDSAGRLIAANHDHPSTDLRW
PDVLGDAWHDVGPQTLFATDGPGMRKGEGGYLFYQRLGTGQWMLLEAVSTAQLYGEVFSR
ISKPLLYVWIALPLLMWISVRLVSLLFSYYLALGHKLQQLAERDPLTDLANRRHFGDQFA
QAAARRERDGSALSMLMLDIDYFKKVNDRWGHASGDHVLQRLATALRENMRAMDVPARLG
GEEFAVLMPGATLAEARASAERLRVTLAAIPVEPAPDAPTSATQGDPGARIRFTVSIGVA
EAGSDGGQTLDAMLATADRRLYAAKATGRNRVCAEDARAGNAEAPPVAG
>A0A6J5AEU7|diguanylate cyclase|EC 2.7.7.65|Achromobacter insuavis|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHKGMKGWLKGLLCVREQGDIAALMAVQKKVGEVHARVH
IPIHLVMAGARILKNEIALRLRASDLDGVAASVATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPSLLQGGPASLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAINDQHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALLVAEKLGAEIRRHAF
MIPEVGALRITASIGVAAFDGHPDYAYLIDRADKALYQAKQSGRDRSVAA
>A0A6N3EU91|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MRSLQSKFLALTVGCVLLSALALGYVGFLYTHKLVNEDSAQFMNLFCEDKAEEINATLTS
IEQSVNMIQDYTIEQYSELGKNGMDKDNTDVLVKKVQEVALHTVKNTEGSRGVYMRVNPE
LAGPQTGFFWYKDENGEVTEDSLVDFSKYAQDDKEHVNWYYEALEKEEAFWMEPYDNKNK
NDWIISYVVPIYRNEDFIGVLGMDIDMALLKEKVDSVQIYESGYAFLAGADYVIYYHRDY
PEGLDEENTHGKIRKVLNLLYKKGTQDNLVGYNLDGIKKKMTARQLENGMFFVVTAPTKE
INASSNRIIRLFLVSTLSIMFISVLITIHVTRKMTRPLKELTEAAQKVAGGDLEVNIDCE
SKDEVGVLADSVQQMVNHLRHYIDYVNEQAYTDALTGVANKAAYKEYVDKLDKRAADEKI
KYAVVVMDINNLKKINDNFGHEFGDMLIRDASRLIQKGFKDHIVYRIGGDEFVIIIEQAE
KAICDELLRNFDDGIVVFNKNNTKYEQKIQIARGIAFYEPDCIDSFASVFREADHAMYEN
KVMQKSMQTAPPAAGQS
>A0A6N3GE16|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKLKHSILGLLLLFTLVPLGIFGIFSIYETNRKIDELTEQNVQAISENQVMNIKNFTQDR
NNEMDIIANYQLTQDAILYSLGEKESPLARNYVDNLLKERKKYSIFVASISVVNRNFHVV
SSSEEYEPGTVSAMKDVDPKYQTGEFIIGDVYERITDDGRKNVVPAYTGVYYNNELIGYV
MEELDTAYFDDLRLNMDTLADGTFYLLDGNGAIITAGDTKNKRSLKTFVSKSSDRNDFQK
KWDAIDHEKNPSGYVRYRYHRQDYITYYSDVENTCWGIRVTENLSAQKQTGRTYGMLITL
GLSALIIGVCCTQYFMTKKIFAPITHILQVFAQIRESEDYSLRVHIQEKHETGELAAGIN
ELLDYVEQADRKEKERQQKLLQMAENDPLTGIKNKKAIEKEMLSMVQRAVESHEQITFGF
VDIDDFRDYNTNYGHQEGDAVIQFVAQTLKENIHGAVGRIGGDEFAFCYAGELEPERIRH
NADKILEILRTQHVNEQTGEVLPVPCSIGIVMSQGDTLDYTQLIRRADLAMYQAKENGKN
TFVLNVD
>A0A5E4REA1|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MKRTLLSTVSLAGRLRWLNLAVVCVVVILCGSLLTWTWGTYQRASDASLALEALRATLLA
MEKASAERGPANAVLGADLPLPDASVIALRNAREATNARLQELLSALSTDRCDACGGSLR
IVERARLDLAAASANVDLLVQRPRDMRGDAAVRDAVDRMIRVIPEFTSVASSRIDVISRG
APDALHYVVLARLAADLREFAGQLGSRFTAALTTGKPLAEVDQRAIERTLGRVEQLHDMI
AARMIDPPELSPETLDALNTQYFAAGLHYVATVRTLASQPQPVAPTTAEFARQYVPTMRA
ITDFRDNMLTLAQRKVDARAALALKWLIVSATAAITLVLGMIVALRNLRRSVVQPFEAAT
RFVEALAQDDLDAAVPGDDMPRQRPQVRAVFDALRVLRLNALELRQLRRDRTRLQSELEM
SGDTDPLTQLMNWRAFERQAQALCAMPSPGLVALIKLDIDNFTQINATWGHGVGDDVLRR
VGAVCLNTCQPGDVVARLGADAFAIVARVLAPSRAQQFAELMRGRIEATTLTLPNGEVVP
LTASVGIAIDDPTTLGATRVSSGGPANVSALLSQAERQLDAARRARRRTIE
>A0A4U9Y1R1|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MIIHLIYTTMYAILVVSLLISYDLFIKNFKELNLRLSFKILIGIVLFISQVYFIISFSLN
SIGYVAYEYTIPIFIYYFGVLKEKIYLVGLVPVILLTFFALINKFDWQAMFFIIGLNYVI
LIVTYSLKKTFYGKANHTFFYLFTILVTVGSPMVDSGLFYRREIGFGDVVFLGIGSGIIL
FLWKYYLHNQKNFLEKINTKIIERNYDELTKIKNFRSLNEDISKLTLIEKNQLIVGMLDL
DHFKQINDHYGHQIGNQALTFFAEKLTTFLDQKIEDPSLVEVYRYGGEEFLVLFRGHTLS
EVKNIIEEFHAFLRKEQLNLDAAQLTLYFSAGISKAEPALDISETFYQADQALYEAKRKG
RNLTIIFS
>A0A5B0KTW4|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALAEAEAISKVFYAILLDRPDSNTFL
SHTLVQERLRPSLARWIKALFTASTDTAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISTKVSAAVEGGWVTPAFVKELNNDVTEIAYILGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRMVEEHRFHGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A7L6ID38|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00570|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A285L500|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. CC120223-11|TrEMBL
MPHVTKVDNPRWLKSLSRHANPGRVVNYCFFIVFFFSTILTWREVVVLEEAYISSQRNTL
ENVAHEFNNQLQVSIDRLTFYRNGMQAALEQPLAFEVLRQAGEEFERKRTQHQWSILLDN
QRTLPVHGVSDAFVDETTILSRENALLGNELTATLEVGYLLRLSTTIKRAPQQMMYVSRG
GFFISSRPVSGNNDLVERYYALVTSPWFADQSQRNNPGRGVRWLSWMLDTPDGPVRRIAV
SLPVDYQHYWFGVLTIEFSLTQMKSMLATAAQGEEEGEYRLYDRQMNLLASSLPEGSKSD
LMSETEKAQLAQAFEHDNRGGLRFTTNYVNWERIRNFDGVLVRIHHLDEGVRGDFGTISV
VLSLVWALFTAMLILSWVVIRRMVRNMSTLQSSLQWQAWHDGLTRLYNRSTLFDLAGKAA
KRSEAKGEPLSVVQLDLDYFKSINDRFGHQAGDRVLSHVASMISSQIREDDLAGRVGGEE
FCLVLPGASKEEACAMAERVRARINNREILIGKGTTLRISASLGVSSSDEKGLFDIEHLQ
SVADGRLYLAKQNGRNQVCCQDEDSQ
>A0A0T9NNP6|diguanylate cyclase|EC 2.7.7.65|Yersinia similis|TrEMBL
MNTITNQSMKPKKNHNSAEKLPTLAGVLRRIHLSVAIVSVVTASIFLTVAALFALRVYVD
HNLHLIARAISYTTEAAVVFGDNVAANELLALIASNEEVAEAKIINKHNRQIAYWTLPDD
GPIHHMEQIVAHWILPAPVVLPMFHAGDEIGKIVIVGHGGSLLRFLLQGLAGMLACLTVS
TLVALFLSRRMLLGIVGSLNRITEVAHNVSRHRSFGQRVPSAKVAELNELSNDFNGLLEE
LEVWQKHLTQENDSLAYRAAHDSLTGLANRAFFEGRLSRALNDCQPGEYTAVLFLDGDHF
KDVNDNYGHAAGDLVLTAIAVRIRALLRETDLVARLGGDEFAVLLTPIHHLDDVLTIADH
IIDSMALPIILAEGGEITVSLSIGIAVYPDHAQTPEKLLQRADEAMYQAKKNFRSGKRIF
VYQPNTTHTESLG
>A0A0T9Q238|diguanylate cyclase|EC 2.7.7.65|Yersinia similis|TrEMBL
MSDNQSDQTIKIADLNEHVVHEILEVISDGIWDWNANSGFVYRNTGWYEMLGYSAHTFEN
TVHIWEKIIHPDDFERVMFHFDAYLNNQVERYQIEYRCRTYEGDYIWIEDRGKVVERNLD
GSVSRMIGAHRNIHNRKQRLEKLERKNKSLEALIEDRTVELRETNLRLQQQLDIKKSLSE
TDVLTSAANRYLLEKVLKHEYLRAKRFCQPLSLLSLDLDDFKSINDQYGHSVGDLTLTHI
VDVIRNNIREIDVLGRWGGDEFMIVLPNTQLKDAKNLAEKIRERVALKLVEGYIRVTMSL
GVVELQHNEAQEQLLIRADKMLYIAKAAGKNMISS
>A0A2T9UXV4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. HN503E2II|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPGLIVNLCFLFVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRELQNSVDRMLFFRQGMGDALQTPLAFDVLKDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDADRIGHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTRDERTITA
SVPIYYDRYWYGVVAMDFTLSTMQQLLAEATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKILT
ETCRQQSLPVSVIQLDLDHFKNVNDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVADRIRCRINSKEILVKKSTTLRISASLGVSSAEEAGLYDFEQLQ
SIADTRLYQAKQRGRNRVVWRDQDRK
>A0A375G382|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MLQDAGRFLALVNPAIAIAFSLCFVLAWRYERTRHYLLLPAAAYGMYAIAITLQIVWPPR
PGGGQATVTGLLYLGSGVLLLRGMLARIGARVDTCTQVALPLALLGAIAWFDLVQPRLVA
RIYILNVGIAMILLLGMPALARLRAGRLADRVLFWVYLLFSLHFLPRTVLTVIPAASHDP
ATFIRSAYWLWLQATLALLLMALALALLAAAVQDIIVGLRHERDTDPLTLLHTRRGLAAL
AVQQXSACGTSATPTR
>A0A5K6CU88|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii (strain AB307-0294)|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIVSFAGAFTGYMVADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGAFFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKTHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLSNNISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A1C3IL36|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MHVKAFAKQISATRDHRLLAESLFDYLIKMLGPQGVGIFAEPIPESDSLPLFSCGELTSL
DHYPSTFWPWVSQFDTADGVLPMSLNTCKWEHSKALGGESFIMMLDNAPACRTYLIIQNC
IAEKVNQTFDQGLDGLQLAAARWQCIRAEKNAAIEIKHRDTREAQYLDEIKLRELFVDNM
KLVHQVALELSNPESLDALYKASVEAVRDRLGFDRAIFMLLDMKKRCFSGTYGTDELGKT
NSEHHTQYDLHQLESEYIEALSDNHTNLVVIEHAPLYTEGKVVGQGWNGMLILREGDKPV
GWIAMDNYIHRSPITNYQKQMLESFGSLLSQIYIRKRQELNIRMLHSSMVELSRCDSVSA
VCKSAVSFAIQHLGIDRLAVFLTDKNCSYMQGTWGTDIKGDIVDESYYRSELVERDIVSA
ARTYPNQVAFEESVPIYHDYNIVGVGWTAMTMLTTNTGVPIAFIAADNLLTRSPLTSQLR
EVIRIFASSLAEVLQRTMAQEEIKKLNETLEQEVSKRTQELENANEQLDVISKLDPLTRL
GNRRMLSQVLDDLNCEEQGAFATQNEVTFGLILVDLDHFGLYNSVYGHTEGDVALRAIGK
ILSTHVYGDQETFCRIGGEEFMLLMIGTNHTTTKQRAESIRQSIEDAKILHCKSSTSQYL
TASVGYASITSDQRQFDFDLLYGKADKALYKAKDSGRNRIVSAMKRRKVAATLT
>A0A241QBM9|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIMGEHSHCVCRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHPWHFDSFQDALLAFTSSVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
ADGEIGITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A7W3IBZ3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGIIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>I4ESE3|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MFTRLAIGMAVLGLAVGAVFPVFAVLLGVPAQYATTAVFRAACLAAGLVLGGANWLLARS
VIGTRLRLLAGRIGEVAQTVGDPVTSAQGPGRPAADLALPVDSADDLGSAARAFNALLVA
LDRERRFRSVVHATNDVLALLTPEGRVAFVSDSTSAVLGWTRAELLEMHAGDLLFAEDAH
LFTTSGAPITHDGQPSQVFLVRVRHRDGGWRHLEVSSSDRRDDPDIGGLLLTARDVTERL
ELQSRLAHQATHDALTGLPNRAAVLARGEELLTDPATPCRLAVLLMDLDRFKEVNDTLGH
SYGDRLLAQVGPRLRPLVREVDMVARLGGDEFAVLLPDVTVAEARAAAERLHAALGTPFL
VDGLSLDVDVSIGVAVCGEGGADVGTLLRQADIAMYAAKESHDGVAVYDPLSDGNDRSRL
VLLSELRRGLADGELVVHYQPKVALGSGQVVGVEALVRWQHPVRGLLAPVDFLPAVERTA
LIEPVTDAVLDLALAQVRAWWAAGFRVPVAVNLSARSLARPDLLGRVLQRLQAHGVPADL
LRLEITESALLAEPTRAREVLRSLHAAGVRLSIDDFGTGYSSMGHLKHLPVDELKVDRSY
VAEMVTSAEDAALVRSVVDLGHELGMTVVAEGVEDAATAAALADLRCDVGQGWLFGRPGP
AVDVTAVLRAGAAAR
>A0A1V6IHY1|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin026|TrEMBL
MFLVMPEDRDFAKKRAIEMLKNEKILPYEIRVLAKEGKIVWILQSVISIRFKGRLAVLGN
FVNITEKKLMEEKLRNMSIVDDLTQLYNRRGFFMLAEQQMKISKRNNKEMLFFFIDLDGL
KSINDTHGHQEGDVALIGAAGILKETFRDTDIIGRIGGDEFAALAVGTSETTRGLLMKRL
NEHIDSYNESPKGCYRMSMSVGISVYNPENPSTIDELMSVADTLMYENKKRKKC
>A0A7D6Q0I0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MIRNTKEIDSILIELNKSIDAHYKWLVRMFRCVVSSDVTQPDIMGENSHFVCRFGQWLDN
QSRYNEDDCSYVSKINATHEKMHLSGKKLLLAIVENRSHSWHFDSFQDALLAFTSAVMDY
KIYLLSIRSNIDVLTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
ADGEVGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDIND
ETSYPLSA
>C9XVB6|diguanylate cyclase|EC 2.7.7.65|Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032)|TrEMBL
MTWREGVILQDAFISSQRNQLDSIATAMDRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTD
AVMAGFNADRHKREWMLPTGRDLAPEIQGVSDAFIAQSTLLERDEALLYNELNATLALGH
MLSIADARSERPEVRTFYVSRAGFYLTNLPFFGHGSIPELYYQQVSSRWFLDQSLRRNPG
RGVRWLHGRDLSMPSGQRVTASIPLDDNGRWFGVLAMDFPIPAMRDFLQNALNDDDSGGE
ILLFDRQLSPITTTSSRNDTALHFTAQDKAALARQMELANEGDARMDTRFIAWAKLDYFD
GVLVKVTTVSQSAEGKFGKVAMVLGLLWLLFTAMLFISWRVIVGMVRNMLTMQRSLKWRA
WYDTLTRLYNRGAFFERARLAAKTCDAQQAPFSVIQLDLDHFKSINDRYGHQAGDKVLTW
AAGMLSRSLRAEDIAGRVGGEEFCIILPGTPSEGARQVAERIRQRINSQEILVRPDTTIR
ISVSVGISEALRDGDYDFEHLQSIADRRLYLAKQRGRNLVCDEG
>A0A2I0CL25|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pharmacofabricae|TrEMBL
MPNTQQRLSQDWQLLLQRHPAGLRQRVAELASQHRADLAEHFYAQMGSDAHAGQFLAHHK
VKERLEPSMQRWISSLLALQDDAELPAQVALQKQIGEIHARVDIPISLVLRGARCLKERL
FSHFSQAFSDGELAAAIGFASDSIDIAMELMSHAYTLAHDRNSRAEEAYRLFSVSQNIGT
ERERQRAALLDWENQLMFEIAAGSPAHQLPRAQKSEFGLWFRHKAQDSFQGAPEMQQIDQ
HLAQIDELYLPAFTQGSPRALEQLREIREAAKAVHYLLEHLFERASDIENGRDTLTQMLN
RKFLPVVLGKQVANARKSASSFALLMIDVDHFKQVNDQYGHEAGDLVLQQVASILGNSTR
GGDYAFRYGGEEFLLLLVDTNAANAQMLAERIRQRVADERLLLPAGVTLQVSVSIGVTLH
DGHPDYQRSLRAADSALYQAKHGGRNRCVFVAS
>A0A7W2WM73|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRALTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADISRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESSRFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNHVATEVMSQADIACYAAKNSGRGRV
CVYESQQSQMHAARGIPSPEEQRNIITHNPMLMIAHGVASPRIPESFSFWLVSLRLWSSE
GDIIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASGVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPGEVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A2S4QA01|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSDAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NEMETLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDVTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVFQE
>A0A378ZTN3|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MQLDVVTLSTAVTLMLLMGAGMLMLVFRFSVRRPSAHADSVRYWAVALGLMGAGIFLVSL
RGHIPDFSSIAAGNGIILLAMSLRLRAIKMFWNKHESWMVTAAPASLWTSMCLVPVFYDN
FLARVVLVNSLVILLLLASIQVTRKYNHDRLRSAKWLRDSMAFEVLSKMAMALGFSLAGL
DSFDAALRSNMTAIYLLTLIISTLATIISAFAMIIEREERLLREQALRDPLTELSNRRAF
FDDAGRWLEKHAFAGKPFAVALFDLDHFKQVNDLHGHAAGDEMLTIFADVLRENTRKGDF
AARLGGEEFAVFLPDTDIRTLEAVADRLRSDFAEKALRRSGGAMPVTVSAGIAAGRSGAN
GLEQTLATADRGLYSAKRAGRNMVRNGHDKPVTGQQEEMEANASVIQVLHLPVASAAQ
>A0A8G0SNE1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MSMHGVRPKMLGFVSEEVSAWLMALVALVAGGLLTALLALATYELYQQQLRQRFELLASE
RYSRIEERFEDQVQRLDGLRRFFVFATEITLDEFNGYAQPLLHRTQAYSWAPRVLGPARQ
GFEQRASQLLGGPYHIQQLSDDGQLRVSPVRPLYYPVLFTQALGPQRQPLGLDLLSQTLR
QDTLERASTPGSMAVSAPLNLANVEPAYARGVLMTAPVFTPGDPNTEPRGYVMAVISLRQ
LMAEGLPNATQDNLVVRIRDLTGPDAQHEVLFQSDNQGVSSPLAASHLLHLADHDYQLDI
RPSLAFMQANRSSAVNAVVFLGGLLSLMLSALLFSLFSQRQRALTLVEQRTGELRISEQS
LRNTHNQLRSVLNAATQVAIVATNLRGVISTFNAGAERLLGYSSAEAVGSLTLEALVSPQ
ELQQRARDLSHRYGREVTPAQAMFAQTVPEGGNEAGEWTLQRKDGSHLLANMLVTAVLDE
HGLWVGHLAICIDVTERKRVHEALAARDRLLDKLSAEVPGGIYQFHLRPDGSSCFSYASE
GLREIYEIEPELLRQDATAVFERIHPEDLLRVRNSIRYSAEHLTPWREEYRVVLPMAGQR
WVRGEATPEPEEDGSTLWHGYLTDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLKAE
LERAQRDQQELALIMLDIDHFKRINDQYGHAVGDHVLRSLCQRISQRLRRTDVFCRLGGE
EFMVLCPGSNADQAYTLALELWQGVRSVLVEGVGQVTASFGVASWRPGEGADALLLRADS
GVYAAKQAGRDRVEAELP
>A0A5E5B370|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MSHTLPPRRTTDSTDSLYSSNRLAQTAHALWRTSGSGGMGRGVDRVDVADADADAGAEAI
ASPYLPSSSGRSRIDSVTDVFDRESTWLHARSAVTSESPAKSASSPSPFMAFAPGASLAS
AMRFEHHESFEPFLQLPNSRPEPSPSTALLSSTRWALPTRRDMTASGHDSSDANDLNDAR
ARLLRSTGSPLGRTASVGLDEAERLAALRRYEILDTPPEPAFDRIVRLASHVLGAPISLV
SLIDESRQWFKARRGIDASQTPRSMAFCAHAILSDDVLVVPDARADRRFADNPLVTGDPN
IRFYAGAPLRTPEGHRLGTLCVIDRRPRDLDDEKRGLLADLSSLVVDELELRRVNRVLGD
MAMRDGLTGLLNRRAFLMQADRLFAVARAQQRRLSVLMLDIDHFKGINDTWGHAIGDRVI
VELTLVLRAALRKSTVIGRLGGEEFAVLLPETDAQRALQAAERMLVAINGASVPGPNGNA
PVRFSASIGVASLGPDDADFSTLLQRADRALYTAKQGGRNRVAVL
>A0A378IJA2|diguanylate cyclase|EC 2.7.7.65|Legionella cincinnatiensis|TrEMBL
MPSEINLAIIKRVLHLGKENNLEFLLSRIGNGITITDQYSKILYVNSGFTRITGYQYEEA
IGNNPGMLHSGRHREPFYQQMWESILTNNFWEGEIWNRKKSGEICPELLSISKIDDPENK
TYYFLAIFSDISFLEKDLPEKINLAFYDPLTKLPNRNLLYERFKTFINHIHENSSAVKLS
ALCYADLNKFKEVNDVYGHLTGDGLLEHVANTINSHVRSGDTFARVGGDEFVFLLPNVGN
EKEVNFFFERIEKELKKTIEINGHQVSASMSVGVVFIPPTSQLSDYKKLMDLSDESMYYA
KKNKIGISFHRDL
>A0A514EWQ1|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MTNNDKPNMTAQSWQKHYDKKYQYSLRLFLLLNFISAVLSLVSPLYTPVSYTLPCMLIVI
LSATLALWHWKFSQHKINILFISLIFGVLWASHITEKALSLPEPHFNFLVIALLSILFIG
AIAFPNNIIAFTLHSVPTFIACLFLAESEQWLRMLYCLTLPIAGITLQGIMQKRNDAFTQ
GLMDKLLRERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLSVSDSGHHVLLLDIDHFKAYN
DHYGHMMGDQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTNCTPEAALLAAERIRQQV
YDLKIPHMFNESVATNVTISIGMTPPAGDRYRWRPEKSRYGALRSKRPGTQHYPRQLISP
PCAAEPTAQTNFLPSPGQITSITNHYHLDSYLAI
>S1EWG1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE73|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTWGGIRMDSRYVSWERLDHFDGVLVRVHMLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A1X3LXM5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA249|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0N8TYZ2|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MFDFILRPFHQKLTGFSLLRFKHYHVHQVMLPYSGFLLSVIPIYLLFGLLDYQHLTEHAW
VATLSRVFLSILCIVVLITLRRYASKYLELAELFLVLTVYMSIITIGKLAMTQGNFDYQS
GGVLVMVYIGALSRMPFKLSLFGLSLMLLSYLLIIAPDRIGQDYGEELDRISIFFAVFLI
SLVASLRRDSETRKSFQQFSQIRRQQLRLRASQKKLALQTVTDPLTELKNRLYLTKNGPQ
IEQSAQHTNKPLSVLMIDIDNFKSINDTYGHQVGDNVIYGVAQIIRQHCGRYTGMNVRYG
GEEFLSVFQCFNEQQLCQIAEKILDDVPKLYWPNTHLRVTISIGASIDVKQRWDLNELIS
HGDKALYLAKQNGKNQIQLITQ
>A0A5J6W6K6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. E76|TrEMBL
MIKKNMRVEVSTPHPVLRLLSLGLLSFLFTLFSLELTLLGSSLAPLWFPTAIMMVAFYRH
PASFWPAIAAACVAGNLLASLVLFPSNHIVITFPLINILEALLGAILLRKLLPSANPLQN
LNNWVKLAIGSAVIPPLFGAVLAVIFTPNDENLRTFFVWVLSETIAAIALVPIGLLFKSH
YLLRHRNPRLLVETLGSLCLTLALSWLALHYLPWPFTFIIVLLMWSAIRLPRLEAFTIFL
ATVMVVSLTLTRNPEMLTAPHPSVMVNAPWLPFLLILLPANVMTMVMYAFREERKHISES
ETRFRNAMEYSSIGMALVSIDGRWLQVNKSLCQFLGYPPEKMCGMTFQQITWPEDLHDDL
EQLESLIKGDINSYSMEKRYFNHAGEVVWALMSVSVVRDNNGAPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELGPDIISWDKRMFELYDIPPHIKPTYQLWASRVV
KEDLGSVEMTINDALKARIPFKIEFRIQVSEGIRHIRALANRVINKQGDVERLLGVNMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICTDVDMNVTFMNPVAETMSGWSQEQAMGQPL
LSVLRITFGDKGPLMENIHSGDVSRTAIEQDVVLHCRNGGSYDIHYTVTPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQSVGENHQRHALVCID
LDRFKAVNDTAGHAAGDALLRELASLMLGMLRTTDILARLGGDEFGLLLPDCGIENAYTI
STRLIQAVNDYHFMWEGRLHRIGASAGITLIDASNNLASEVMSQADIACYASKNKGRGMV
TVYEPQQQHLQQQRTLLAHEEQARIINDNHMMLLARAVASPRIPESINFWLLSLRLWTSE
GNVLEEASFRSGLTDPALSCALDRRVFTDFLHNHATAITLKGFGVALPLSPQGIASDETI
NEILAALSTSALPPRLLHFTLHSDVLLAEDERAKNNMIKLRNAGCRIIVSQVGRDMEIFN
QLTRQMCDYVMIEPELVTDVHTNLMDEMMVTIIQGHAQRLGLKCIAGPADQALIMDTLSG
IGIDMIWGDTIAQTQPLDMLLNQGYFAIN
>A0A5J6W5V2|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. E76|TrEMBL
MSAKIQQHAWRARHPIKIVNFCFLVVFLCSTLLTWREIVVLQNGWTASQKNRIQSVAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAQFDQQRQSGAWQIRLDTQRGLLVN
GVSDDRVRQNPLLARDEQRLENELIAALEFGAILQLADPQQDRQRRTFYTSRAGFYLSSM
PHAASDDIATRYHRLVTRPYFHSHTQRNNPDRGVRWTHAREANRQEDQVVTASLPLDYQN
QWYGVLAMDFSLGTMNDFLNQAMFRRENGEILLLDNQFQVIASSAEPVPAGSVFSDSERE
RLTREMAEHNEGGALIDTRYVSWAKLNFFDGVLIRVYSLKQSLSGEFGTILLVLGLLWAL
FSLMLLGSWYVIRRMVRNMFAMQETLQWRAWYDAQTHLFNRGTFLERARQIARRCQQQQM
PLCIIQLDLDHFKRINDTWGHQTGDKALSHAASILRQSLRGDDIAGRVGGEEFCIVLPGT
LQPEAAAIAERIRVRLNSKEILVRQNTTIRISASFGVSCAVQEGDYDFEHLQSIADRRLY
QAKQAGRNRVSSSDG
>A0A1C9W4W7|diguanylate cyclase|EC 2.7.7.65|Microbulbifer aggregans|TrEMBL
MNSGLPSDAYDLPSPVEQARKIELRRRILASGYMLIFAMAITGAMAVMALTDGEMVMSGV
LFGIAGIILGAYVAINLLGQSGKTPVLVGLLLVVLYFYLLLSGGVKNTGLMWAVTLVPGF
INLYGYRTGTATLLAIGGATALILFYPEFPGLTAEYDTSYRARFLAVFGALTALTALLDS
SRHQTQQLLHHLTEELEARASTDALTGLVNRREAYRAINELERRDHQMHGRYTVLIGDLD
NFKAINDEYGHSFGDRVLRDVAQVLQENTRVGDIVSRWGGEEFLILLPNTDLDGGGILAE
KLRQRVEALSDTYEERVKVSISFGVAEGGAHDDTHGELLAEADERMYRAKHHGRNRVVAV
>A0A5V0IV04|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATITH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A857K1L1|diguanylate cyclase|EC 2.7.7.65|Pediococcus pentosaceus|TrEMBL
MENTVMNTIIYWAKGFFSFNTVVIAAITVGVLFMLAAGTYVVEMNMDKTKTSSTLIEELL
WGVGLTIAMVFLQNVFTHLYSTIASSELGWEYSTAQFVVLFYCLYIVHRKVVLWFNIILP
MYVYGLGIVRGQIGFDIAPILAILVIILISYTIYQQNDTLIDENVKYYSTLIMFGLAWWF
VLKDIHHLTIVDIMCLTLEFLIAMSIVHFGNKKVRMIMKQYLNLMQEVDTDALTGVYNRN
SFNKVVEGVFEFYSNNDAPLTMVMFDIDHFKQFNDQYGHQVGDKVLRLVADRFSYELVDR
KAHGQLFRVGGEEFAIIFRGRTADDCEKIVRAIRDDLVKETIRVNNHDRVGIKVSIGISQ
LRDDDFDFQTFYKRVDDYLYQSKRNKRNSITVEGKVASLN
>A0A744UP15|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAAL
>A0A6L5C221|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MSQSELHATALALYPEDYREAAALLKQAVPLMVRHNIPPNPVHYALWYTYSKGLEPELNR
HLDRVVKDFDYFPSESASKLFRDFIIRDELEDARAGQQQAINLVDGMERDVSHSVSGSLN
FKASLGQCLEMLEEPDDKRLPTILIELQQSTQAMHDQQERFLAQLHSAQNEIKSLRDKLQ
RAQLDATLDGLTQVLNRNTFSRVLEQALRTEAQGVALVMLDIDHFKQFNDQYGHPLGDRV
LEHVGQVLRNSLPPQALAARYGGEEFCVILRGCADLSAVRDVAELLRQKIQALRIKARGT
NEVLDTVTASFGVALANAHDTVESLVVRADDALYKAKRNGRNQVV
>A0A5U2M2A2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLQTMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A626SGS8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEVLVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A633UIQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLASEIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A748A6R3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A739CPA8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MDEAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVSQPVFGGWWLLLVGWSF
VWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALFMMMSMNLMGAG
GRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIK
LAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLIIDIDHFKSINDT
WGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSRVHERLNT
LRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRTEVAA
>A0A627NK77|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDREHALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0F3R095|diguanylate cyclase|EC 2.7.7.65|Rickettsia amblyommatis str. Darkwater|TrEMBL
MTTILVVDDIEPNIKLLTAKLLKEYYTVLTANSGKEALAILKKGKIDIILLDVMMPEMDG
FEVCKTIKTDPETTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSR
MKSLIDELKLRNSTNALLGVTNIEMHDTFADKKILLINDDVVQAKNIKQMLLKITQNVKV
ISNSDELDIINEYTPDLVIISSTLENDDPLRISVILRGKTEISGVVIILQIDEDGMPLVV
KGIELGINDYFVYPIEESELLARIRTQLKRKQYQDNLRNDLEQSVNLAAKDGLTGLFNRR
YFDIHLKQMIEKANKESIKLYLLMCDIDNFKHVNDTYGHQAGDKVLTIVSRILKNTLRVT
DLIARFGGEEFTILLTDIDISKAIETAERVRVKIEYMDFHIEDQIEPLKQTISIGVTKYK
KEESIESFIERADKAMYEAKTTGKNKVVKL
>A0A2T8TD86|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDCERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0T9L3K9|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MFCLKKNGVALSVFIIHVIVNIIYLHMGNNMLKDTARFSARTAELTDKTIPALTAFRCLI
TDTLQLRQLQLQLVNAHDDKDIEEERDVINELIIRIENTFYMYSKTLSESDNRQDIDDAY
HAWLRYISLSEKAISLYQNGFFNQARNILYSDALSYFVDFELRKIRLLINSSEQLSEAKM
AIAEVDKSAKALFILGLGFSLLLQITYLVIIFKQVITKKRAIKEANIDPLTHLFNRRKLV
KDWEVIHSLNKPITLAAGDIDHFKKINDTYGHPVGDFILCELANMLKKNSRKSDMVIRIG
GEEFAIIFINCHVEEAYQRIEKIRKEVEETIFTPASGDNIKLTISFGLKQLSKDTPSLDS
LLKAADNNLYKAKKAGRNQTVY
>U9ZS27|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907713|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKISQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2H5ZE71|diguanylate cyclase|EC 2.7.7.65|bacterium HR29|TrEMBL
MKVVIFAPNTRAERRLRARFEAWGLEPVSPNAAGDPPDVVVVCGPDIGPLLDQVERWLPK
FRTRPPVVAVNVDRSTVTPAEMARCDAVVLGRLRRDEFAARLQAATRRRIFQGAGRPFRA
LVEALPLGVFATNPQGACEFTNPAYRRITGLSAEEAEGTGWAKAFHPEDRDALFDAWTAA
TLEGKPYHGVVRMTRPDGTTAWVRITTGLVRDGGRTLGHVGVLEDITQQREAEQRLREAH
TLLDVIQRASLDAIFVVGKKREVLYFNERVIELWQLGGTRNLARYEDRMALLESQMREPH
RFRRFVEAAYADPNLTGRMDIVLNDGRVFELYTAPAITPDGEWIGRVWYYRDITDRRRAE
EERDRYFRYSIDLLAILDVDAQFVRVNPAWTRVLGWTEEELLGRSIFDFVHPEDARGSAD
AVVRVRNGEELRDVRARYRTKDGGYRWLSWNVAPTRVYAYAVVRDVTELVEAHERQEELL
AALEARMRDLEEQARALDELRGQAEYAATHDALTGVWSRRAWFDAAAEIRPKALALFDID
HFKRINDTYGHPAGDAVIVEVCRRLEQALGSDTVLGRLGGEEFGALFQCDPAEAERRAEA
AVAHVAAEPVRVDRRTAIPVSVSAGLSAWRAAAGSREASLARTYEAADKALYRAKRAGRN
RLVVAQGRAAAA
>A0A8G0S7L7|diguanylate cyclase|EC 2.7.7.65|Bacillus inaquosorum|TrEMBL
MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYFSSLCISLTPSPSDSVA
NVADDEVRFSAYKINASFYKIEDVSGRRFHLTCRQDGEIPEGLPDVVASFLNQSKKQERL
YIQTIYQKKIYKMTELFHSLLDQTEVLKQLLESLTRTFSLFKFSLFISHDQDQCLGVPAK
ELYMEGEKSDSFALKVYLTGDILRKNESAAYIPIKGQQGTYGVLMAEGTGGSFITDAYLD
EMSLIANAAGKAFENAQLYEQSKASIANLELINETSRRLNQRLTLTDTMNDLAVRMAESF
QAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDFYHELKEKLYEGEKGVFIGNGQSVFGK
AGYGSLMAVPMIENDRLLGFAVLLKQEMYAFTFEMYKLFQALIHHATLAVTNSMLRDRLE
HLVKTDQLTELYSRVYLDEKIQYSMKIHQKGVFILVDIDNFKNVNDTYGHQTGDEILIQV
ASVIKSNIRKHDVGARWGGEELAIYLPNVTVAVGKRITERLVYAVRKNTKPEVTISCGIS
CWTAETRKSLKELVHEADEALYSAKRNGKNRMMVHESIK
>A0A3P3XM93|diguanylate cyclase|EC 2.7.7.65|uncultured spirochete|TrEMBL
MKLAHLTKIKTFESSKRFLIKKPNEGDLIILQNQWNQLKILLHEYDAKKGPSVEFNNLSE
EIWVQANIVVTGIENSFHSYIKYYTVIAIVLFSSIIMLALISFAIKYFIQQRVEVQASHD
YLTGLFNRNYFDILLKRQLHESNRNNQNVAIMLCDIDHFKNVNDTYGHDNGDKVLKAIAE
TFMMTSRASDTIIRFGGEEFLIIASYQNIDDLMRYAERIRMNIENTKILDLNITISIGIA
ICDHSGEVNKVIKKADTALYTAKENGRNQVILYDNIKK
>A0A7R9R806|diguanylate cyclase|EC 2.7.7.65|Candidatus Methanoperedenaceae archaeon GB50|TrEMBL
MAVLDLYRIEDGNKIQEQLINEVYELRRQVAELKKIVIEYKKLEEKLKYLSFHDSLTGLY
NRNYFEEEMKRLNTTRKYPVGIIIIDIDNLKFVNDTFGHVKGDELIKYVANILSSIFRKE
DVVARIGGDEFAVVLPNVNEKIVQSLCKRIKDNCNRNNNPLKVSVSLGYDIQYGQYKDIK
EVFKMADSRMYKDKNGKKWAGS
>A0A4U0GK24|diguanylate cyclase|EC 2.7.7.65|Sinimarinibacterium sp. CAU 1509|TrEMBL
MNIRGYKPAIDRQPVAEAKTTRCGGSRSMQPEPSDHLQPSLRALEQAIYSHELWVKDLLR
TIICRLPVDRRDLDADAHHHCRFGQWFYDDAPRELRRLDGFAAMESEHEHLHRLAAKLLH
TVMSDESIHSNDYDEFANTRDRLLLQLQTLKQQIEEMLYNRDPLTGAETRTQMLPVLRDL
HAMAQRKVLDCCVSIMDLDHFKQVNDNFGHQAGDRVLSAAVSRMQEVLRSYDKVFRYGGE
EFLILMPNTELSVAHTVVERIRERLAAEPLTHHNGTPVSITASFGITWLDSGCGVEESIH
RADMAMYAAKKAGRNCTIVWSPELADPHATNGVHRRDPPPG
>A0A509CQ66|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 7297|TrEMBL
MFPKIMNDENFYRKAIEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFWRRRICGDYVRNA
GRQRDYRHVASA
>A0A2S0XCJ2|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MDNSGAGNAGRSWAPVARYALLGTAACVAVAAGAAAILFQGQGDQVFWRGVIGAGVVAGL
VAAPLLTIVANERRKFGALKSEVSRLSSTDALTSCLNSGVFANLIDAFRGSSASGGRRQG
ALLVVEIDDFRAINAKFGHAWGDEVLKSVAGTIKASVRAGDLVGRIGGEEFGIFLPGTSR
ENAERVAERIRGTVSDTVLEPGARQLPLSVSVGAVLFEDQVEFDDMFRHADDRLSEAKAR
GRNRIEFADMSEDGGKPSLNA
>A0A8F9XAG9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MSDDAQRWKEKYLLSIEQQEKLERRWAARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRD
VVRTDDMDAALAALLPRLEKAVLDSEQRRETRVDQISTALTALVSQLQALPLPREVSRPL
KSFAKQLDSRVGQAREIPLLLSELSGLQGQALSNLESDDEPARPGLLQRLFGGKEAGTEV
APVEPAVSPPSRQPPAVAASPATPVVEDAPELAQALRAFAPQAQAPQQPVLEVAPAPAPQ
PVAPRVDVDECVASVPEVGAPRLSPVETLAVAIETPEPPRPVEVSLAPLPERAVAAVVVA
PEVLPLVPQPTEIGSLSLPPVLDDESAEVDPEALYALPDSPEPSYSSVAKHIEDTLLGLL
GDLALPERHRPQAQAMRERLAQGLNWYELLPILDDLAVLMLAITDSGQHEFEAYLKHLNE
RLEAFQSNLQAASDGHADSRSAAREMDTQIREQMDGLQSSVQEAADLDDLKQVLESHLEG
LLGAMDEHQRQRDQREHEVAARLQGLAERVASMEQEAQGYRDHLEVQRQKALIDPLTGLP
NRAAWSERLEYEVNTWHQQGNSLSLAMLDLDHFKRINDSYGHLAGDKVLKIIATVLSKHL
RPTDFIARFGGEEFVLLMPDSALGGALELGERLRAAIEACPFHFKGERVTITMSIGMAQF
QPGERSDLALKRADEALYRAKAAGRNQVQAA
>V6EYS5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MSDFAQRLTRALTIRYVAVLVIIGALAVGSFLGLVRVLMDAESGTAIVNASARQRALVER
AADLAVQVQAGAVQAGKIEQDLHATLDRLETVHLGLLQGMPELKRPQPPVGRVKALYYGP
DGALDADLRLFLQHGRGVLVSRRGDAAMAGDVAAMVEAVKGRLGQQLDALTGLYQQENLD
RLRHMFGYHAAVVALVLFLLVLSAAAVFRPMVTRIRDDLGERLRIEKNLRESEDRLWRML
QESPVGVSASRRKDGLVVFANARFCEILRTDAKNLLGQRARNLYVDNQQLSDIVHELKDK
GEINDAEVEFRRFDGEPFHSLLTVKASHFEGEPVNLAWIYDISAMKAAEEKLKLTAKVVE
SASEAVVITNAYNEIEYVNPAFTAITEYTAEEVLGQNPALWRSGRHDAEFYQSMWAALND
AGRWRGEIWNRRKSGEFYAEWLSIVAIKDDAGVVSHYIAIFSDITHRKEDEERVWRQANF
DALTGLPNRALFVDRLSQAIRQSKRDGKKFALFFIDLDGFKQVNDSLGHAAGDLLLQQTA
QRLVDCVRSSDTVARLAGDEFTCIVQGVHDSTDTSMVARKILERLAAPFDLDGKPAHVQG
SVGIALYPDDGADGAELLKMADEAMYRVKRRGKNSFEFA
>A0A5A9ELU2|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. Sh1|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYREGRGGERSSAPASFQAWCQAASRDDL
LQQPAVQKLATLHEQMHRQARLILLKSSGGELPTEAEFEGVVGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETRLDEGYEVIERLRVDLMRSPVVLPDG
RMIPVTASFGLVEAVSDLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEPKPAAAKAG
RG
>A0A379XR15|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGNPVTAEKRRAFCNAFETINGTHGVNLIRHNYPALHGTLQTAATQCTDN
LDDVLLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDLDSGKEIIINQSKNNLFQYVNYNHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTKGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAVHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRS
>A0A0N1JRE3|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MLSPATLLIITALLCTMMLLVMLSLRRSRLPGIREWTWAIILEIVALGCYLCQNAAPMVI
GYVLANSLIALAICLFYAGCRRFFRLEVPWTGMIATVALVAVVIPVLRYPVDYMNLRVAF
MSVVHGIISTMIAYTIIKYRPAYRATHGHMLTAVLALVFAIGYAIRGVVYLHRPDNTPLL
VDGSIINLIFLSLGALIMPGLTMGAVVMTHDTLLSQAEAIANRDFLTGVLSRKAFIEQAQ
REMARASRYGRALALVMVDIDHFKAINDRYGHPTGDAILRDFALLAEASVRDGDYIGRLG
GEEFGILLPDSAGPAAAVMAERLREQVAARRYRAGEQIVRYTLSAGMAVWQPGETIEDFV
ARSDYWLYQAKQSGRNRVQGDPAT
>K0AXV9|diguanylate cyclase|EC 2.7.7.65|Gottschalkia acidurici (strain ATCC 7906 / DSM 604 / BCRC 14475 / CIP 104303 / KCTC 5404 / NCIMB 10678 / 9a)|TrEMBL
MDNIRKKYQILILIIVLVMGIIIGVIYLYSMKSVEDIYEQYAEESIIDVKKSFIKDNVNN
IISNIEQKKEKKTKYYKQLTDNSSEILDEYYQHSQNIFLDLCIEYFKFKDNKDIFSVLIL
DKVSNTIIYDRDYSNSNKEASYTERISLMKHNLSSYFQNSYGQYDVFWGVSKDYIDDIIK
KQIHDEIHNSKFSNDAYIWINEVVNYEGGDNYAIRRVHPNLTDTENELLSTNTKDIKGNH
PYLTELNGVKKNGEIFFNYYFQKKNSNIISEKLTYAKLYKEYDWIIAMGVYMDDIESYVE
KTTTESKQIITRMVTHIALWIIWIIILIIFFLTLLEKWYYKNYNMTLNKEIYIDPLTKAY
NRRAAVSHISSAFKNFKKTGLSPAIIMIDVDDFKKINDTYGHDAGDFVLINIAEILNKHI
RSTDILCRWGGEEFLLICDRLKADDVFSFANKLLDSISQFEYESNDNKYKVTISMGVSYF
DDFDNDFNSAIKRADVALYNAKNQGKNRVCM
>A0A853GCE5|diguanylate cyclase|EC 2.7.7.65|Alcaligenaceae bacterium|TrEMBL
MSRFSSEQLEHEWKSLLLGVSPAILSQIQILIKQHANDMATHFYSYMLQDPVASQFLSHD
QVKTRLHNSMQNWLTTIFSIAPEDDLKAVVALQVKVGEVHARIDLPVHIVLRGARGLKNR
FHQLLSASDALDDAQRAQIFQLSFSIIDLAIEIMSQAYSGFHDRNARAEESYRLFSVAQN
LVSEREKQRAALLDWENQIMFEYAIGHSGSALPALGTSEFGLWFRHKGAHAFQGAVETDE
ILESIKKVDQVLLEQFQTQAEPNQQDRVLQLRELHVHAKAIAFHLDNLFEQHNELEAGRD
VLTRLLSRKYLPAVLNKEVQYARRSASVFGLAVIDIDYFKRVNDQYGHDAGDAVLQQVAA
ILNNSARGSDYVFRLGGEEFLIVLVDVKKDGALGMLQSLRQAIQNEVFRLPQGQTVRLSV
SIGLAFYNGHPDYQQILHRADTGLYKAKESGRNQVVVVDMS
>A0A7Y7HZP2|diguanylate cyclase|EC 2.7.7.65|Duganella sp. SG902|TrEMBL
MSEAQVIAADQDPVLTIFKVRVLLVDDQLIIVEAVRRMLSDQPDIEFHYVTDATKSLETA
LQLQPTVILQDLVMPTIDGFGQITQFRNEEGLRHVPVIVLSAKEDPKLKAHSFAMGANDY
MVKLPDKLELLARVRYHSNAHISRLQRDQAFRFLRESQKQLADANIELQKLAALDGLTGI
ANRRRFDDTMRLEWQRGQRDKKPLTLLMCDVDFFKLYNDSFGHLAGDLCLKKVAAVLTEH
LKRPADLAARYGGEEFAIILPETSLTGALIVAESCRRHLEQLAIENPQATTALSSVTMSI
GVASVVPSPASSVEELIQQADRALYAAKHGGRNRVVSAADLPGLTPSNQGKTAA
>A0A1H3YM24|diguanylate cyclase|EC 2.7.7.65|Marinobacterium georgiense DSM 11526|TrEMBL
MPRFSTEQLCTEWTAINQRFSAEVQQFVIDFSRRHASSLSEHFYREMLGDPAASQFLSND
EVQSRLGQSMQRWVAGLFVSTTEGDVLRLIAEQRKIGEVHARIGIPVHLVLRGARCLKDR
FVQLLHEVPNLPDEDQYAAMRLASDTIDLTMEVMGHAYSLSHDRNSRSEEAYRLFAITQN
IASEKEQQRAALFDWENQLMFSQAVGTQLSELPRIQSSDFGLWFRHKGIHAFEGSAEAGA
VMDTMEEIDSVLLPLFGSDGGNTIAISQDSRVHLLRDLRDKVKSIRFHLSNLFERNDELE
SGRDVLTRLLNRKFMPVVLSKQVSQSRTQKTAFAVLAIDIDHFKQVNDIHGHQAGDSVLQ
QLALILLNNSRSGDYLFRLGGEEFLLIAVDMDATRARTVAEKLRKSVERESFLLYDGKEL
KATISVGVACFDGHPDYQRVLRKADDALYQAKNNGRNRVVVAMGGGASEAG
>A0A2H6F282|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin06|TrEMBL
MEQLLALHKRYKKRSSLIMIDLDHFKRVNDLYGHIIGDQALKAVAECVRQHCRASDVLAR
HGGEEFIIICSDSNIQESRQLAEPIRESVEQLRSETLGFPGPQTVSIGAYELSSDEELSV
DQLFSRVDKALYRAKKEGRNKVVISTQEQVEK
>A0A509BCF6|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 3046|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6H1FRA8|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. FDAARGOS_727|TrEMBL
MNKDLTTSSRPTFKGTLRRISVISVVIAMLIIWLLLSVASMLTLRQYAQKNLELLAVTVS
HSLEAAVVFRDGAAANETLTVLGKQGQFTAAKVVDAEGKELTHWQMEKSTQRDMVGGLVT
RWLYPHPIKQPILHNGKIIGEMRLIGADATVTLFVWLSLAVLTACTLLASAIALGISRHL
HHDIDVALQNITDVVHDVRSNRNFSRRVPPERIEEFHLFAQDFNSLLDEMEEWQRQLQLK
NASLQKTALQDPLTGLANRAAFRNALDKLIEDADSLHNTALLFMDGDNFKFINDTWGHAA
GDAVLIEVAKRLLTFASTRHLAFRLGGDEFAMLLHAVDSDAQASTVLNQLKEVVEQPILL
PGDHWITMTLSVGVALAKNIHSAENLMETADRNMYIQKHKQRQLLNKQLHKD
>A0A7D4III5|diguanylate cyclase|EC 2.7.7.65|Achromobacter pestifer|TrEMBL
MSSSSPDVPLLSEPHTGASSQACYLSASNEQAWVAVYQSVDAYTRGQVAAVVGDSLSELV
DAFYSTLLADDEAGPRLSHEIVSSRLHAGMTRWLKGLLCVRDQGDVGVLMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPGLQQIMDAVAQLDGVVLPQLMRGEELGQASAMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISIARRQRSAFSVLLLDIDHFK
AINDQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDTASEAALATAEKLG
AEIRRHVFNIPEAGPLLITASIGVATFDGHPDYAYLIDRADKALYQAKQAGRDRAVAA
>M5ESM1|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium metallidurans STM 2683|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTATNGPDAIETCENGKVDVVLLDVMMPEMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLDAGADDFLTKPVNDLQLMTRVKSLV
RLKTLTDELRLRASTTRNIGIEELLSRNFASEDTMPKVLLIDERKSSFERIQKMLRGSAD
LDIATDPHAGFFQAAETPYECVMISTAFADFDPLRLCSQLRSLDRTRFLPIILLAEQGEE
GRLVRGLELGINDYLMRPIDQQELTARLRTQIRRKRYNDQLRASVTQTIEMAVTDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKTINDAHGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGVVAERVAERIRAEIAQLPFAVGSEGKTIEVTVSVGV
SSVLKGVDTVAGLMKRADLALYEAKSGGRNRVVAKAA
>A0A653J8R7|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MYNRAWLASNEHALLKAGTWLAHIDVDHFKSINDRFGHAAGDAALVGLAQALTSATQESK
ALRPGHVVRMGGDEFLVIMPEASLLTAQRLAQNARAAISRPGPFEYTVSTGLAVIEPHDT
SFTDAIDRADRQLYAAKLAGRDRVAA
>A0A143HSQ1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHLDTVASSLDRQLQ
NSVDRMLFFRQGMHDAIETPLAFEVLQDAVSRFNTVRMLPTWQIAVDKKRTLPINGVSDV
FVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRAGFFLSTDTLDQA
GDITSRYYHLVTQPWFTQQSEQNNRARAVRWFISTPSSWTNDERTITASVPIYFDRYWYG
VVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTENAVNHFDERETAQIAQ
AIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISIVLALMWALFTAM
LLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLAETCRQQSLPFSV
IQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEEFCVVLPGIGLEE
ARSVADRIRCRINSKEILVKKSTTLRVSASLGVSSADEAGNYEFEQLQSVADVRLYQAKQ
SGRNRVVWRD
>A0A376F8A1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MFYYARSLKTQHNMQMQTSSAWESFYVMSDIILARVSETLATEQSLEGLVRQLLEMLEIV
TDMESTYLTKVDIEARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTVFSNDVPE
RWPECEAAKALGITTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQS
IQKESLVTQLREANAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNTVIAFIDL
DDFKLINDRYGHEAGDQFLIEVGKRLTEEKRQDDIIGRLGGDEFLVASLSTSHSEGDNAQ
VTLVKTRLSACIAGEYWLGSVNLIYPGASVGVIEVDPRVTDPDSALRDADVAMYQDKKGK
SKTRFLTMD
>A0A376F877|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MKRRTGTRVFLTVMLLDIDYFKSINDNYGHECGDRVLASFARQVQQVVGEDGMVARMAGK
SSPWWSIQATRSTVLNWLNVSEPPLPAILLHGVTRRSI
>A0A3S5YIG6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae serovar 18:z4,z23:- str. CVM N26626|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A0T9TZC5|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNAASAIFSMILPSPETPAVTLPIVMITVISLSAAAY
LIFISKNYVDKLNLFSIMMGLLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPSAFTVIWLDDFQNIFRIIFTLMLPLIGFSLHHLLMRRSDEFTRKLVAHLY
NEREKFSDLSMIDPLTGLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLASSLKAADEALYRAKKNGRNNVAFAEEKLSSAEPSP
>A0A4P7NYA7|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MKTSLIHPRLLIPFLLVLAFITISPSISASETVKVQLRWLHQFQFAGYYIALEKGYYKEK
GLNVELIPGGPDALKPIDDVLNEKVDFAITGSGVIIDRMEGKPVVALAAIMQTSPIVWIT
LKSSQIRTPQDMADRKLLIMPPPESAELLTMLAYEGIPKNRLNIQDTSYRIEDLIDGKAD
AYDGYISNEPYFLKQRGIEYNIINPKDYGINFYSDVLITSEKMVKKNPTLVKNFKEATLQ
GWEYALKHIEETVQLIHQKYAPNKTLNHLRFEAQTLKKLIMPELVQIGHMNPGRWKFIAK
SYRDLNMTTADGNLDGFLFKDNKKTDYTLVAAISVASAILLLIACLIIFKFRKLSLDLKK
SNQMLEELAIIDQLTQIKNRHGLFEEASIVLSQAKRHNSPCIFLMLDIDNFKHINDTYGH
PAGDVTLISFAKTISKNRRKHDIVARLGGEEFGILLVDTNLEEANKIANTILKNIQNLTI
QVPNTDVQFSITASIGIAPAIGTLEEFWHLADKALYQAKNNGRNQIAIMQENDE
>A0A4P7NZX4|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MLSRLRELRELSKRGVQDCSIAIMDLDHFKRVNDTYGHAAGDQVLVAWVNYIKKNLRKYD
RVYRYGGEEFLLSFPGNDQQSVKELIERLRDGIPEITLEGDEAKSIMVTASFGITTLDPS
LHVEESINRADIALYAAKKAGRNCSCIWDSSMASMHNVEDGDLDEISGETSKAH
>A0A5C5Y7P9|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MQHFGTTTRIAFAMAMWTATVLLMLRMCGVIGDRTAETIRQRSEMSEMVAVTCSQFASRD
QTDAIAVTLAALVQRDSDVLSAACVADNGEVIAETEGHPKRWLADSDNESGATQIKVPVY
QGDGHFADVQVTFRPLVAQGWLGFFGLRSVQVTLLATLGNLLGFLLLLRRCFRHLDPSRA
VPERVRTALDTMAEGIVVADMDGRIRMANQPFAEFCDSVVNELIGKDIDDLPWVIKDDAK
FTQLLDAMASGGRQSADLLRLSPNDSEERILQPNASRIIEGEQCHGYMISLADVTSLEQK
NQQLEYLATRDPMTGCLNRRSFFEQMETHWSGAARHGHSIGCMMVDVDHFKSINDNFGHA
VGDEVLVAVSSALLEMARGSDLVCRYGGEEFCVAMPFETIEGAKMAAQRYREAIESLAFD
QLSVTASLGVSSNALGADSVETMLDQADQALYHSKRSGRNRVTTFAELPEETELPAGEND
NHRQEAPGTAEAISGENQVAPVDAESSLLESVQTLVRDLQAEGQSQVPLQRLQGVLADRP
PASNQVDTSVAQSGVH
>A0A822X9B2|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MALHSKKLSFTRPIMLSFAGILCSFALIAVVVTLSQRKDFLEDYHKINGNFTHNLAVNYT
ESILRENDYILGRSAMYFARDDRLNETLNVNPTQGLQMMMHLQNLMPTVSSISLADTQGH
YLRAPEVLQTEKSKTFDPRTRPWFVAHAEASIFSHYTRPYMDYFNGHPTVTLYKPLISPE
GRLKGTIAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGVLFKQYVSEALMD
KMTSGEGHLYDKKTDAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRTVLMTIINAIKTGDVSQAPRLEAMLSRTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDNDVEELLNTHQPFAMALVDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHHVSVYRYGGEEFAVIFQAEQIAAAFSLLDAWRTAVERRVWREENLHVTFSAGLGEW
HFEPLEQFVGSVDNALYSAKKQGKNRIVRTAVG
>A0A1C5T4L2|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MHSQKIHNKKLILPVLIFLAGCLALAAVLYHSYRTNLKQVRAVTELNAITYAERLQNDMN
RGVAITDTLEEIVLSENGKIDNFQKVAGNLMTDFVQSIQVAPDGVVTDIYPEAGNEAGKI
DLIHDESRGEICRYGRDKNIVTMQGPFDLKQGGRGIAIRNPVYLECPDGTSAFWGFTIVI
IRIPEVFEKSVQALTQFGYDYCLTKTVSPLSDDTEVVSSSGNILKEPITFEFEFCGSTFG
LEVMPTDGWNHGWNILPQLVFGISIILLLTGLTVIVLVVERHREILKKMAITDPLTGLLN
RKGFDEQLKKMIQDDHCIHCVGAQMDIDDFKFINDMYGHVVGDAALKSLAQDMKDSFGVN
AILCRNGGDEFSVILIGTTEEEAKSKIESFTLKPRHITYNGEEHPFYISLGYAEYPKDCD
DVSELIRCADMALYAVKLHGKHSCSPYRSDYKIQNRSQLGFALQDVSKNLPGAFLIYIAD
PEDDRILFANRELIEFAGCKDFDDFLDYTGQRFKNLIHPDERDSVETSIWKQIDAKTSGN
NDYVRFHFAKKDGSYRPVLDHGRIVENRYYGNVFYVLIMDCALVESFYDGFSR
>A0A379VNG1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MSKPSQHVFVTVPHPLLRLVSLGLVAFVFTLFSLVLSRVGTQLAPLWFPTSIMMVAFYRH
AGRLWPGIAVACSLGSIGASLTLFPAASLNFSWTAINIIEAATGAILLRKLLPSYNPLQN
LNDWFRLAIGSAVIPPLLGGLLFWLIAPEAVASKAFLIWVLSEAIGALTLVPLGLLFKPH
YLLRHRDPHLLLETLLTLVITLALSWLAMRYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
ATVIVVSLMLANDPTLLATPKTDVMVNMPWLPFLMILLPANMMTMVMYAFRTERKHITES
ESRFRNAMEYSAIGMALVGTEGQWLQVNKSLSHFLGYSQDELRTMTFQQLTWPEDLNNDL
EQLNMLVRGDINSYSMEKRYYTRNGDVVWALLAVSLVRHKDNKPLYFIAQIEDINDLKQS
EQENQRLMEHITQANDALFQEKERLHITLDSIGEAVVCIDVAMNITFMNPIAEKMSGWRQ
EDALGTPLLTVLRITSGDKGPLLEDIYRADRSRSDMEQEIVLHCHNGGSYDIHYSITPLS
TLDGDKIGSVLVIQDVTESRKMLRQLSYSATHDALTHLANRASFEKQLQQRLQTIQESPQ
HHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSGDLLARLGGDEFGLLLPDC
NSDSARFIVTRLINAVNEYHFMWEGRLHRIGASAGITMINEHNCQLTEVVSQADIACYAA
KNSGRGRLTVYEPQHALTSSKGMMPLEEQWHMIKNNHLLMLARNVAPPRTPEATSFWLVS
LRLWTSEGK
>A0A377P8S2|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MLEREKISFLAKGHFLSVASFLLLFCLFAFLIRFGAHRVDVLRSFFPVSTAIVFVLHLFL
TIIILIRFHFKNTHLHLLAIASAYGLSSLFLANSLFIYPGVLMSESNINESANALAVDFV
IRSFSMAVLFLLSVLFYIKGKCNYVNKSNVITSCAAVILIAIGFAVVIINHNNILQLPII
ETDELNYRRLWSSHIGSALIIIWVITTFTVVFFTKLVNGFWFSLSLSCLAFLGSILLMWR
SEYVTSLAWYGSHFFEVLATLFVVLAFIYDIYKLYQKGLEDYIESYENSIRDSLTHLYDR
RYFNKTLASRIKGASEASPVSLFFIDIDHFKSINDGYGHPVGDKVIRRVADTMVASVRKT
DVVARYGGEEFAIILKGLNSKSASKIAENIRNRVSEEVHVHGGPEKVTVSVGVYTITDHH
LSVDESISRSDSAMYQAKKSGRDRVVVYSHSASEFEHTTA
>A0A509E6J8|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MPTSRFLSQQGGRFARRSYPARLIGLALGFLAVGAVFQEIHAPIWLWVSLVIYSFIWPHI
AYFWASNIRDSFITGQRQMLFDSFCGGLWAVAMGFNLVPTVVVLTMLAMNNMASGGIRLF
IIGLAVKLLSIGLFSALLGVDLYLESSLRVMLASFPFLVIHPLAVGAMTFQFALSLHTQK
NRLRKLSRTDGLTGLYNRRYWQSRALEEFNRCHRKIHSALLIMADIDHFKAINDTYGHTT
GDDVIHRVAEIMQRQLRNIDLIGRFGGEEFAIVLPDSDMATGKEVAERLRLSVANDLEDE
NIPVTATLSLGIAEFSHDFDSFEDWVNAADEALYEAKDRGRNCFCCYSPNKTLRVVSSNP
GKDSSKSQSNQQPS
>A0A554XKE1|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MSAASPLLRDTPQRADWREALLNDYALAVLTLGGVVAVVWLAPFAVYRALTANWLAAASD
AILAIAIGAAAWYAWRTRDTRWPGWVMAVAIVGGIWAIGLAAQFAALFWAYPGVLMNFFL
VPAPAAVVLGAAAVLGAAALSWQELGGTEGLPFFVITNVLTGVFGYLVSQQAHRRIERWQ
ALSLLDPLTGVGNRRLMEVEFAQAFRCGASVGALAVLDVDHFKAINDGHGHEAGDAVLRD
LATVVQSALRKTDRLYRFGGEEFVVWLGQGDAAAAAAVLERIRQVVRERVRIADRAVTFS
AGVAVHTAPESWQACLARADAALYRAKREGRDRVVWTSPGEGASSRT
>A0A1S7S4L0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tomkonis CFBP 6623|TrEMBL
MSETIDTNIFNLAPVAMWIEDFSAVKSQFDIWRAEGVEDLRAFLLEDLSRVAACSQKIRV
IQVNAKTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSELWAGRTEFTSNAVNYSIGG
RRLDIQLRGAVIPGHENTLGRLLLTTEDVTEREEARRKELLNRRYAEGMFKHSPVSLWVE
DFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLTHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDELNRLERSALRPVSAIVIDLN
GLKEANDKLGHDAGDALLRRVGEVLNGVVAAPNHAARIGGDEFAILLPGADKQIAAAMVE
TVYELLKINNQFYSSAPLSLSLGVATSESGEAMESLVRRADMNMYEHKNAYYAALRSRSA
DNSETPKSSPQPEATSLKRLF
>A0A822WKT2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MLAICRFVKNRFVAFALGCIVIIAVLQAFFIKLVEWVPSFSPLFFPTLTIFLLVFHLFIA
CFMAMKYWCDRRRLYLVPIALAFAGSALLMVGTLSSFPAWLDLYQFNVANYNDAMIFYMF
RHFLMAVLIIISALLYTLRTSALSRSTHIGIVVGASLFTGSMLGLALFYSSHSTLLTLDL
VDNETRQFMVLWSQAINIILIVLWVVTLITLMAITRVRNLFWVGGNFLCVCYIVTLLMLL
LGGHAEDISWYRARLFETVATLIIIFILLSDVFNLYRDSHVKYQESYQNSIRDPLTRLYN
CSYFYDSLNHALSTATLAHPVSVIVSDLDRFKRINDCYGHLQGDKVLQFVSNLLTDSVRP
QDIAARIGGEEFVLMLTNTPSDLAQQVAERIRLKLSGFDNVSSGGYLPEPITISMGVFTA
TSPETSAETCVESADKAMYEAKETGRNRVVVFRT
>A0A6L3Y0E7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKVINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQYYRLGGDEFAMILYGVHTAREVEFICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A8F8D991|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAIIAGVWMGLTGFSALPTA
ALIMMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PILFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A8F6R798|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDTHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQMAFRSAEPHSREVVNLKVDAIVAGVWMGLTGCNALPAA
ALIVMIGMNMMGSGGCRLFLSGVALLALSALLTVQFTGTPVVLTSEPLTLWLTPPVLMVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A0U5IGJ8|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MEETLCLRVCSHFRQDVETALATLGEESVRVQAYPAVCTLSPGRCSLGDARETPPPEGSD
GALVLLGCDAATRAPPPDPRVHLVKLDHCIHLLAGSDVLEPEIQAGAYLVTAGWLKRWRE
HLHGMGFDRETAGEFFRECSRELLLLDTGSDAHAFEELEAMAQYLGLPCRSRYVGLDYLR
LFLSGAIAKWRNLAAEAKTREILTQANRKVADYAMAFDLLVRLSHITDEDATIAAIQELF
AMLFGCINLVYAQVEEGRVKEIFAAEERPRDRLDLQQALDALHEGYLIMPSGNGFFLRID
YQDTVLGLMLVREIPFPAYRDQYLNLGLAISNLCGLAISNARTFVKLQETEQSLRRERDI
NARLFQQVRALADTDPFTELLNRRRFSELAEVEFARAKRYSNPIAVIMLDIDHFKQVNDT
YGHGVGDQVLKAIAERLRAVRVSDILARYGGEELVALCPETSAEEAERLAERLCLALRER
DIETTEGPIPITASIGVATLERGVENLDALIDRADQALYAAKSAGRNCVRVYGRNADVSG
P
>A0A0U5J485|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MSLRLNRLIRHHWRPSRVVPASTRAATRGYLVALSGSLLTLGLATWDYRERMSAITADSS
RQDGELGVTLALTVAMATTAIALLFYLRFRTLARAELRDLADLDAAGETLRALLGTVSHG
VILTDIDGRIRLFNPAAEILFGRLGEETLALPIEILIPDLKLADLSDLSRCDPGLGPRVR
HLVGVRADDRRFPIRLLLRPLTLDGETYWLLITEDRTESERSEQRMEFLEQCDPLTGLQN
RPTFERILGALTPAPVVGSTAHALCLIDIDRFKIINDTFGHAAGNKVLEQLGQIVKTKLA
AATALARLSGDEIVALFVGNAASQAKDLCEDLMRTTRHFLFTWQDRSFDITLSIGLVVFD
PARTRAIDALGQADIACGVAKEKGRDRLHLYGHRDAESIRHRGDLALVPAIGSALSEGRF
RIMAQPIQPLRGSNEPMHYEILVRMQDEKGNAVVPDTFIGAAERHILMPAIDRWIITHVF
SHQSEQLAAWHEAVPDRFMLAINLSGTTLMDDGFTTYLKRQFAEYAIPYSSICFEITETA
AVADLRRARTFMQEMRALGTSFAVDDFGTGFASYAYLKLLPVDYLKIDGSFVRNLETDAV
DRALVSSINHIGHVLGMKTIAEWAETPQLIEILREMGVDYAQGFGVGRPLRLEDLRLHRA
LNKDASTQSPAAVRPQPIAF
>A0A8I0CGJ1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
AAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASI
LSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIF
NQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFL
>A0A8H1Y054|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDPTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8G8M7P8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIADVDQK
>A0A8H1YC76|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQATAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLAGLSSATLVNE
LIEQLENSPLPPRLLHLIIPADAILDHAENVQKLRLAGCRIVFSQVGRDLQIFNSLKANM
ADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLI
YGDVIADAQPLDLLVNSSYFAIN
>A0A7A6VI35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
GAVLLRKLLPWYNPLQNLADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSE
SIGALALVPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLL
MWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIM
TMVMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELR
GLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGT
PLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYE
IPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRV
LNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPV
AEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYD
VHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRIL
LQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGD
EFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMS
QADIACYASKNGGRGRVTIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRI
PQARNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGL
SIALPLSVAGLSSATLVNELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRI
VFSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAG
PVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A1V2GJT4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRV
>A0A828AI34|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKIEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A7U1TN70|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLLSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARTLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A137CD10|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYYAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVGKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8G2LN46|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASIPSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376FP79|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRD
PLTNIFNRNYFFNELTVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNII
GKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTIS
IGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A5E9YVH9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVALLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A827GAU4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPADAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNRSYFAIN
>A0A376RJA7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKNTNRKHLLSRIQRYIPEAYSHPFDW
>A0A8B4NHV2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSLSPSYLYDVGPYLISSDECIQVKEFEKNYCTDIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKSVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYFQVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECATVERL
KMLADERLYKSKKNGRAQISWQ
>A0A6D0DJF8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDMDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENTDISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQETPFVAHPALHS
>A0A8G8C1Y5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNGVLAA
>A0A828GAS8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNDVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTHNGDIVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A2X7L004|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYHNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A5F1E1P3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSTSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSL
>A0A828H4F2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLNLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7B9SZC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEQDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376TK84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVVDGGFLPCHPRAYGHYRVVQ
>A0A376ZYI6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNCFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDT
WGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEK
TKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376FMT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYES
>A0A376TGA4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKTRFLCALFSD
>A0A5B9AJV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTVRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTPATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDHHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1V5QV06|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MLAGLVAWLHFISGLAYDFHLLFILPVLFVAWFAGAVAGCVVAVLSVLLWYWADRLLLGA
QVEFFPLLFNKAMRLAIFLTGVWLLHQLRKVLERESQLAREDALTGLHSRREFYSQGRRA
LALAHRQNAPFTAVFIDLDRFKEVNDTLGHETGDQLLKAVSAALSAHLRASDIAGRLGGD
EFALILTGMGYGPAAHYVEELRQRLLHAMQQEDWPVTFSIGVASYRRAPDDFERLLARAD
ALMYEVKNSGRDDILIRECSLLERPDPQQHGQADGDDQDLEE
>A0A161R0X0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>W7WFV9|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MISGNYPDSVERSSELLRLALPQMAKHSVALHPINYAVWYEYVSGRSGDLKAEIERLTAD
GRALTEADVARLFKAYVAPVGLETSERVAENARRILRSMEQDALEATDRTSAFDQSLSQW
QAELDREANGGAVLQGVVASTREMSEAMRQLQSRLDVNQREIAQLRAEVAAARSEAQTDS
LTGLHNRRSFEQHIAKFLADREAAMSLVLVDIDHFKLVNDTHGHLFGDQVLMAVARVLKE
SVRNDDLAARIGGEEFALLLPSTPLKGAVELAERIRTSIANSRIRRRNSEQQVGQITVSL
GVADLWPSDNGESWFSRADEALYASKREGRNRVTAPSLLARHAVTGGVNRS
>A0A827JY13|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQSRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEKACRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQSVITRV
>A0A484X1R9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAHCSKKARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLR
AQDVAGRVGGEEFCVILPARV
>A0A3L3TGY0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKR
>A0A376VM40|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQ
TATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKS
INDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHE
GLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>A0A795ENS1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSQRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377DTE3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTI
FKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFR
YGGDEFIIVLTEASEKRNVTYRRTYSQSGGENQTESRKRRRYCPLTFHRCRHV
>A0A6D0DKS7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQNLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKWLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCTRKGDLVFRWGGEEFVLLLPGTPLDTALSLAETIRVSVT
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376U9T0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVVRMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKNALS
HGKYWRR
>A0A4Y7ZBY5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGVSLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376DEF6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVK
EFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKS
LAMDSENLMFSLFKNGKSVTGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDVYFQV
CTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKL
YSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLM
KVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGV
AHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A377AIZ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMTYSLEAAVVFADGPAATETLAA
LGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFISHWLFPAPSFSRFVTM
>A0A5B9AXU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRPGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHARQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A379D2S7|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MRESAPPLENRGVPGLRFVKRMFAMRILGTFFCFFPILSVLDELGRPALLIVLLAINAFI
WPVVAWLLARRAAAPLAAEHRNLIVDAGAGGFWVAVMAVNPLPSVVIVTLLLTDRLAAGG
APLLRRAVLAMLTAFVVCWLALDLPVQLYVTQRTMLATLPLIAVYLLALSMLTHDIATRL
RRKSDELERIAMQDPLLDIANRRLLERRMTTELNRMRQRRCRSVLMFIDLDNFKEVNDRY
GHKVGDTMLGIVSQILTMVSREGDTPARLGGDEFVLLLPDTRGEEAALIASRIMDAAAAM
AVLPDATLTLSIGIATAGPEVQDVGAWLKLADDALYEAKRRGKNQVFAC
>A0A5E8NTA4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRSLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRIRASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A109CRJ2|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MQNILIVDDREENLLVLETLLAQPGVNIVKALSGKDALWNLLRNEFSLVIMDVQMPEMDG
YETASLIRSNSKTKMIPIIFVTATYKEKKSMYKAYESGAVDYLVKPIDDEVLKSKVNIFL
LLDKRTNQLNKANEALEKEIKIRKEAEEALRNSLSLVHSTINSTADGLLVIGADRKVKIY
NRAFAQIWNLPENLLSTKDDNALLSHVLSQLKDPDGFIRKVNELYDKPKDESFDIIDFKD
GRCIQRYSFPQVEGDNITGRVWSFHDITEHQKLTAQLRLQSEIMSNMAEGVNLIRSGTIM
YCNSKFEEMFGYNPGELIGQNISVVNAPTETSPAVKEITESLDKYKLWQGEVRSQKKTGE
HFWCFVTVSTFEHTEYGKVWVSVYTDITQRKKAREDLERFFALSIDMLCITEIDGYFKVL
SQSFEKTLGFTLDELKSKPYKEFIHPDDRLVSLDAVETALQGIPLYNFKNRFLCKDGTYK
LLSWMVLPVTEEGISYCTAVDVTEQVKMQDIMKQDLVLQSSIAKVTEALLNPKYDKYYIS
KLVHDESLILTDSEHGYASLIDENNDNVAINLTDMMDRQCKIAKEQQTTKFPKGPTGYNA
LWGHSLNTGEGFFTNTPKGHQSYKGCTPAGHLEIKNFLSVPVKSGSKVIGQIALANSRRA
YTERDFSIIERLASIYAVALERKQIEERLSESEQRFRVIFNETPVGIAITEVNTGRFVQV
NKAYCSIIGYSHNEIVDYTFHALTHPDDIQQQLDGLRQLHNGDISVFNMEKRYIHKDAKV
VWVSLTTVSFLQDTGKPLFYLNIVKDITHEKQLSEYLKASQIDVMEAQSKAHFGTWTYDP
VTHQRQWSLEMFNIWGLDPKQGPPHSYIKYIHPADYPHFDNALREAVELGKPYTLELRII
RPDKTERVINTICEPVLDAAGKVVKLRGSIHDITEREKTEKELIRVVTLLDITGHIAKIG
GWSLDMETMDLIWSKEVYNIHELDVTQPPDFETAINFYPAEVRLSLIDNIQDCMNTGRDM
NIELPFITAKGNHIWVSIQSKAERKDGKIVRLIGSVQDITQRKRMEDALRIERDKLKSIM
DTMEDGVYIVTKDHEIDFINKALVSEFGEVNGRKCYEYFHDKNEQCAWCKNDEVFSGKSV
KWEWRSSKNNRTYSLYDTPLRNVDESMYKFEIFHDITDIKTAQYLIQRELNYQKAVAEVS
EALLSPDKTIHDISCIVHKQTMSLTESLFGYVSEVDSNTEELINHAFSDMAGQQICRVDP
RYFRLTFPKGENGYNALWGHSLNTKQGFYTNNPLGHPSYKGVFPEGHVRLIRFLSVPAMI
GDKPIGQISLANAERDYTDEDLNVITRLASIYALALERKRMEIKLKELNTRLEAMVEEET
HKRQQQEQLLIQQSKMAAMGEMLALIGHQWRQPLNAIGMSVQDIKEAYEYGELNNEYIKD
TVDATMNQVFFMSKTIDDFKNFFKTSKEKVRFDVSAAVKELTAMFEQMFKKSDVDISIRT
EPGTLLTTAGYPNEFKHVILNILNNAKDAITAKKETEIHGLIEINIANDEAKDKIIVTLR
DNGGGIPTDVIEKIFEPYYTTKGEEGTGIGLYMSKTIIEANMGGSLTVRNIDGGAEFIIE
LTVRR
>A0A1S7LI62|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MALRRSKVVLPLLGGFVVFLLSLAGVWLHNYYASEQLFKTMQSSETVVRKMHLVSDLMEV
ARVRTRILAQMLDEEDSFANDEHIIRLNREAGYFIEQRNKLLTFPLDQVEKSILEKQRNT
IPPIIKAMDEVTQIVMWEDEEEAKARARKIHYDIVLPGQGKVVDHFMRLQAHLEKQITRV
TQASINSHRKHLNQQLAVLILAVLLILMVMFVTIRRITRIETLLHFEKERAQITLISIAD
GVITTDSQGVIQDANQAVGHLINRQPNELLGCTLEEILPTQGHAEESPALHEYLQELLGC
EECMPVNTLATLGEGDKQIILDATLSPVRNDQREVLGSVITMKDITEKHRLAERINYQAR
HDQLTGLFNRHSFSDLCRTSMEQMKEGDVHTLCIIDLDRFKTVNDTCGHKAGDAALKEIS
EMIQNHIRKHDHAARIGGDEFTIFLEDCKQEQANVVMDKLLDEIKAYRFVWSGQSFTLGF
SIGICEIHPHIHFEKSFQAADAACFEAKDAGRMCIRNGHVDESEESEEKPTKAGEVSWLP
RLQSAMEENRIVIALQPLEVNGDEANQGQLYEVFMRLKEGDKLHPPMAFLPTAERHGLTG
QLDQKVLGCVIDCLKKDPEGGNRYSINLAPKTLEDPSAVEGIIQALQAHPDEARRICFEI
DECAIFNNIKQASTLLKLLVDAGAMTAMDNYSGSLGNCTAMEALPLDLLKVDGALIQQSV
ERPTPRAIVSSIHAISLTMGLRTVAKQVESQEQVDMLRQMGFNYLQGFHIAKPEVREK
>A0A379KQR1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPHAKHGLRLDLRTLILSLCTLTALVMLCASYFASYRVQRQLLIDNALEANRVYAAKLAA
ITETFIATALQQLSFSASVQGRQLADGAALEAETTRLLRQSMAFNSTFVVDAEGIVRAIS
PAALRHYLGRKVQTPGTEEALRERRPLVSTPYLSAANNLVVALSQPIFDANGRYLGYVGG
SLYLRERNILNSLLGKHFYKDGSYLYVVDRNRRLLYHPNAERVGSVVEGNTLIDQLKELQ
HGTRQVINSQGVAMLAGFATVPSTGWGVVAQQPLAQTVAPLSHLILTVMGISAPLALVGS
LLLWWLALTIARPLWQLAAGARTMDRTGNAERLHRVHAWYFEAAELKRAMLFGLNLLQER
IGRLNRDAQTDPLTGLGNRRSLEFKLSLLEAEGRAFSVIVLDIDHFKRINDGHGHDVGDQ
VLQRLAAIMRGCCREGDLLCRTGGEEFLMLLPGAGLVVATTVAQRLRVMVQDTAIEPVGA
VTISLGVAHWHAKQDREPGAALSQADSALYRAKRGGRNQVCSEAGGH
>A0A379L137|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MALDPPTMLTISVALAAAAALYLAIEWRSVRESSLLFWSAGFATITVGCMLALLRGIGLL
FIGIWFANGLLVVAHGFFLWGVLRFTQERLSRAWLVIVLVWFALLLLPVGPQWSKVMLMV
NSLLVAALTLKASFLLRPHGKSLSVGAVQLRYVLLLHGVFYVVKAIIAIAPGTLIDLATF
GGLIIQVSLVEGAMAIMLIALSMTGTVRYRREERIARLAARDPLTALYNRRALEVRAAPF
FKDVSPTQPGALLLIDIDNFKLVNDLHGHIAGDRLLVALSEMIRTVLPERSLAARLGGDE
FVILLSGTSNERVLDLGGILREQFQLYAGKTVPTPEAVTLSIGANLFDQPPASLAALIEQ
GDVALYQSKRGGRDSIRFVERSMAGVGQ
>A0A168NRS3|diguanylate cyclase|EC 2.7.7.65|Clostridium ljungdahlii|TrEMBL
MNRILFDALDNVNEGVVILNEQFKILFWNSYMKHITGIGTKYIIGKSIYEALPNFNRNYF
NESIKSLMNNEYKLFFSATMHKDLVNDNGKFNLKISKLEEGKSRFLFLEFINVTNEFERV
NQLKLYINKLFLLNKKLKDKEKVIRNLAYYDKLTGLGNRVLFYEIAEKILDSCRRNNNML
GLMFIDVDNFKSINDTYGHTTGDNVLVKVADILKKATRKNDVIARFGGDEFLVLLPDIKN
FNNYKIIHSRIINTKKRIINLCGNKINISLSTGVSFYPQDGKSIDELIIKADEAMYIAKN
VDGNDNCFCSKYIV
>A0A1V6AU45|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MNNETGNDVLLNGASRFSFTPKDDPDQALRIRRLFMASIAYVLNASLAYFSYLAGITEWP
AIVGLMIIIPVVNIVFYIVIRTGLNLNFADPSLTFAQMCAAILTIMYVMYYANESRGLLL
LMYVIMMLFGIFRLNTRDFFLISILTLLTYGADIVLLYIFRPEGVNFRNEFLQWIVLAIV
MIDFSFIGGYISSLRRNLRTSHSELKKTVENLNISQSELEKSLAIIQEIAIHDELTGFYN
RRHLMELLENEKNRSLRGNSTFTIAMLDIDHFKQVNDTYGHQAGDEVLRRISAAIKNTMR
NTDFCGRYGGEEFVLVLIQTDLKEAMICAERMRTNIEKCRFPDIGDGFRITASIGLSQYQ
MREEIDTMIARADRSMYRAKEGGRNRLECEA
>A0A2N7QTG5|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MRLRAGAWRWVALLLLVCACTPVAHAAQPWSLFGQPPLEPPVTTYRAISGDLPPHDYGEL
PAWLAARQQLGSVSMLGGDYWLVAPLQTPDDAPNWVVTFGNTYYQRASLLILGDDGSRQR
LEAGRGIDTNFMLRGTVPVALRPGHRYAVVIRVSTPFFTALPRIDLQTRDAHRRRLTNES
ALMLMALGVLGGLGLFILFVGLWTRVLSYTLYGCQSLILLAGWASFFGLPDDWLGIGGGT
LNFTLWFILVPLVHAPFTIRFLELKRHAPLAARIGYGIAIACAPAVPMALLMPSLSFLIA
TIAVTSVVLFSVSVSIWALLSGVRQARFFVLAYVCVLVPGAIILPVNFGLMPSPLDNADL
LTLMGNSAEAMLLAFALADHMKLVQAARERFRQGMLDAIARASTDTLTGLGNRLAFNMKI
EEITRHQHAPAPIVEGAWQVAMIDLDGLKQINDNEGHERGDALLQAAGRGLSRLPCQGHA
YRLGGDEFAVIAFGDELSLHRLTRALGKLDQQLQAYGFQGAGLSFGVCGAPTGQTLDSGD
FAELVREADRIMYEHKSGRRTPPASDRETQVETET
>A0A1V6HBT6|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin058|TrEMBL
MMVDVDDLKKINDNHGHAAGDKLLRSVATAMRESLRRMDVPGRWGGDEFAVILPDICLKE
GLEVGKRIIDSLKDYSFQVRDQIITPSVSIGIAAFNECCPQNVTNMLALADGALYQVKNS
GIKGSVTAACPDMVNKVQLRLES
>A0A0T9T0Q4|diguanylate cyclase|EC 2.7.7.65|Yersinia aleksiciae|TrEMBL
MNSHSYDQLLNSKHRLSLLLFLFLNASSAIFSMVLPSPKTPAVTLPIVMITVISLGAAAY
LVFISKKYADKLNLFAIIIGVLWAWQIILKYEYPGTNENNYLLLSLFTIFFISTIALSDN
FIAFCLHTTPAAITVIFLDDFQNIFRIIFTIMLPLMGFSLHHLMSRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQAYDLASSLKAADEALYRAKKDGRNKVAFAGKRFPNVESSP
>A0A8F7M1E9|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MKILMGCGLLLWLGMTQALAQPPRLSEPELLRELQQLEDGGLPERIFRDRVAVLADKKQV
YPEEVQGRIARLQCWAQPSERDDDFLRAVQFADQGLDRARARKDRVTEAGLLACRGYHRQ
LLGNMAEARQDYDAALTLARRLGDERQRADILSLRGEMFAYQGDLAEGLMELIDAHRRYE
GLGLEGKGREVLTRIANAYRRMGLYERAESYFKELEHDYRVLGDREHLVDIHSQQGLLYI
ETEEYDKALPLMAEAEIYYLGQQQEGMLAWSRVEMATLLLKQGKTAQAMAKLEQVKTQLL
RGKGADSVTLGHWHLIMATALDAMDRPAEAQRHLDEAEPIFAREQNLRFLARVHEVRARV
LERQGRIQEALASLKTFVQTRQALELRLREQRSLQMRFEFDLARKELENQTLRSRQQLQE
EKLKQLQERRYWQYLVVTLLLLVMGILVVHQRGRTRKMQRLAMTDELTGIHNRRQIQAKG
RKWFTQAREEGKPLSVLLLDVDHFKRVNDQLGHQVGDRVLTAVAQCIEEQLRSLDRVGRN
GGEEFLVLLPDTRLDEAAEVAERIRLAVSRLAIEGVPADHPIRISIGCAQYKPEDDNLGE
LVRRADEAMYEAKLAGRNRVVKAA
>A0A8F7M3B2|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MNDMAAVTGQLARLRESLQQKQQELDGMATFSETERARSIQFIGKLMQACRGHDRELDNR
LAKLKQKLDGSPPLTSIDAELAAIEKLLQQHSHAMEESISLTRAAIDLGSKQLKTIKGFP
EETRRALKEFLASPESYGIGDHQKKVIRLLEFYQQAIKIQLLPRQPLIPPSAEIPTELSS
PSPSDSFDVKAHAQISDELQRLITELDFAGAVGESLADIRRQLLGGITPALLAEVCLQII
ELIIEGTREERKASQAFLSTLNESLSAVHFSFTETLDEGRALQDAAHLSGQALERELAAI
DRALITHDSPARLKGAIGGHLDTIRRLQQEREEMVSRERHLLTHLSNMEAKLRLMKEETG
EYKKRLTIQKHKLFLDSLTQVHNRAALDERLELEYKRWLRYGTPLCLAIIDIDHFKHIND
NYGHMAGDKALKVVAKALQNALRDTDFIARFGGEEFVVLLPNINPDKYQKPLENLRQTVK
SIPFRFRDARVEITISIGATLFRPGDHTTDVFERADKALYSSKHSGRDQVNLA
>A0A377HIU8|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MSMPNFKDILDIHPNPCVIHINFVPKYANNAFAKFSGMESAEDVLSLPSIRVLFEKEHWP
EAQRRYNHAIETGIPTPPEVINHMDLKGNPMIAEITDKVIDWYGEKAMCTFVSVVTDQVR
RERTLRDMAHRDDLTNLYNRRYLLDLFSERHAAHQRCQYLAIADIDHFKHINDTFGHPVG
DIVLRRVAREIEGFTTPDEYAFRLGGEEFALLIWADNHGEAYARLEQLRKSLEHCEFRVS
HPNSQPLTLSCTISIGMTVIAATDDFLSASLRADEALYIAKRSGRNNLINYEASIEKTQK
INAS
>A0A7W9YVS6|diguanylate cyclase|EC 2.7.7.65|Pseudorhizobium flavum|TrEMBL
MTARILVVDDVPANLKLLEARLVAEYFDVLTAEDGFKALAICEHTHVDLILLDIMMPGLS
GFEVCERLKADPRYAHIPIVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLV
RLKTLSDELRIRADTAQNVGIEDMLKGTDGRDEPGQVLLVDSRGNSQERFIKALKPIAEV
MAMSDPQAALFEAAENSFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPLLIVTEQGEED
LIVRALDLGVNDYIMRPVDPNELVARCLTQIKRRRYNDRLRVSVQQTIELAVTDALTGLH
NRRYLDNHLRTLFNRAAARGGALSICITDIDRFKTINDTYGHDAGDDILRQFAARIRSTV
RGADLACRYGGEEFVVVMPDTDAAAAGMIAERLRGLIENQPFVIRSTGQAISVTASLGIA
SNEAAVETPEQLLKQADRALYEAKNSGRNRVVAAAA
>A0A5Z8HV92|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rissen|TrEMBL
MILKDAYVASQRNHLGSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQF
EQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLAR
SSAMLTLETMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFT
SAQPYVTDEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNH
LRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVH
TLREGIQGNFGSISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTR
LYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGS
TIRAHDIAGRVGGEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGI
SSAEEYGDYDFEQLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1F2PHW0|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MKETVLIINITTLMVTLFLVYVSYRHRRDKGGLPFLCTMVLLLSWVAGSTIELFAQSYEA
KVFWRNFIQIGMAFIPIANLWFVIEYTENKNKYLKYTVWLAAAISLTGIVLTFTNPLHHL
IRKTVELVEINGHWSLYVEPAFWGNMFVLLRFALMLFSIIILILFQIRIFRSGQKQVLYI
LIGFILALTLLLIKNYLMVGTAETFPMSVIFLIPNLFIAYSVYRHDFLKIAPLAKDWIIN
SLPDGIVVLSAAGEIVEVNPSAAAFFQHFTEPEAAQSPDKASGNKLTNRDFTKYSAFLHS
QSLWQEGLTQRKNGSVELELDTLDGAKHYYEIDLHHFINDRHHYSGSVSVIRNVTSSRLE
RQSLKRQAEMDRHIQVLNKQAYIDYVNASVADPVSLLIIDIDKFKAVNDQYGHPVGDVVL
LKVVDAIKQCIRKDDLVGRIGGDEFSLTLLGCGKEQTQAIIRQILKQVQKETADVLHERV
TVSIGAITDQTLPDHHFETLYQKADEALYAAKKAGGNQVVFYEH
>A0A174Q5Y0|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MKRFDDKNGTDDKKKRKRILFMAGMIAVIIITAALFYFNSFVMKTENSRARDSLLEWTEQ
NAALVGSRIDMYYDLLECAADYISDMPLDEVQTEEMLREKFHRHTEKFDSLKIISEDGRC
VQDGQAYSLKEYFLMAMLGNRGLAENGYSYADGVILSVPVKNEAQQIKGVLCGTLPCSSL
DVYGKADRRKGYAGLFVIDNHGKYIVSDGGNDTFGNDFLNWLEGRELSVPISDIKSRMDS
GFRYYFAISGEDGDYMVTAAPVDGTELFAVTMADNRYIHQTGLRYRIWVFVITLVIILSL
IAVIGVYLYFRREDRIAIRNLNRQLTLNEETYRITAGESDLCVFTYDVETEQIQFLNDKY
QNLGLDQSELSVPVLLRKIREINPETCSVIRDIFARVDSAEALHSQKVKVWAGGRMRYLQ
VKTTNLYDESGKVSRMVGSIEDVTDMENDMLKLQKEARTDLLTGAMNRAAGTSAINRMLV
QELHPGCVNTFAIVDLDNFKTLNDVMGHMWGDRALCEVVLIMKKHCRAQDIVCRLGGDEF
VVFLPDMTREAAEESLRVLSAKLHIDYVKENLEVMISASMGIVFSDGRDITFQELYEEAD
GCLYQVKRTFKGSYHISDRAGQEKAD
>A0A1C5U7C5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKSHFELKNYVTATSVFVLAVVAGILIFFGCVQRSVQVNSQKTLKTNVERQREHLWTIL
DINYQYLNEIASAVGKSEELFSEENKERLVSIYEKTDLERVALIDKNGDAYYDNGATKNV
SHRRYFKEAISGKQTLSDPLESSVDYEVRVVLGVPVYKNDKVIGVLGGSCNVTALSHMLF
DDLFDGAGNSFLVTSDGEIIAFDSGSASSTEITYGTNLFEYYGEKNLRGKHTLQDMQVDF
KKGDNGLVKLSLGERKEEVCYLAYMPIGYNDWMICYTVPVKNAQQVYDFISRYELIFMGA
FCILVAMLVLYIIVRNNKEKAALIRSAQTDALTGVYNKENTQNMIDEILRKKDPDSFHGF
LILDMDHFKEVNDVYGHAMGDKVLEMLGNFLKKQFREQDVIGRIGGDEFVILLYNIGSRQ
NMENRVKSLQEKIREIHMDGMEGHTFTLSAGIAFAPQDGDTFMELYQKADLALYQVKRSG
RNGYRIYK
>A0A1V6BNV3|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin135|TrEMBL
MEPLYQVERNIKIRLLLAHSLLWLLGIIGIVFAVNRVSAQVKQIKQSEEKLKTMSLADEL
TNLYNRRGFFTLAQRQMKVAERTKKDMLLFFVDLDKMKVINDTLGHQEGDKALIEVSNIL
KEVFRESDIIGRMGGDEFAVLAIDTANETKEVLVNRLHNTLNDYNRFEGRSYQLSLSIGV
AHYNPETPSTLDELMAQADELMYEEKRNKKH
>A0A087DTW7|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium subtile|TrEMBL
MPADNAGPEAQLLKGTVLIVEDESSLATILAGYFKKAGFGVTVTSNGLDAVDMARDDAVS
VIVLDLGLPGIDGIEVCRRVRTFSDAYILMLTARVEEVDELIGLSVGADDYLTKPFSPRV
LVARVKALLRRPRNGANHGTAGNGDSSDSAVAVGDVTIDPPARTVTRRDTSIALTKTEFD
LLATLASQPGRVFTREQLMEAVWGGPAIGDDQLVDVHIGHLRKKLGAPDGSGPKIIQTVR
GVGYRMEAG
>A0A087EB54|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium subtile|TrEMBL
MSNSIEASIVVVDDEPSIRELLVASLHFSGFEVETAASGSAAIEVIEKTLPDLIVLDVML
PDIDGFTVTRRIRQEGITAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTRDEIEDDPIIRVADLEINEDSHDVSRAGQSIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGLEVYDGQGGKRKVVPLIETKRGIGYMIRE
PKTNQAA
>A0A369Q7R7|diguanylate cyclase|EC 2.7.7.65|Alteripontixanthobacter maritimus|TrEMBL
MTKTTVFRRAIGAAAGIVLTLCAVPALADNRQGDRSSSSAQANSAFDAKIGEAQASMMAD
PSAALKLARDAAKAAQGSKRDMAEQILTSQWLEGEALMRLNRADEAQEIIAKALAKIEHL
APSSKLHADLLRSQASLKAGKGEYGEALAFFQDAHDSYKALGEARSQAIVLQNIGSLYSD
ARDYERVLDYYRQANVTYKEDNALSVSAHNNRGNALKALDRFGKAEQEFRLALASARKMS
SPMLEARIFTNIASAQLKNGQVGAAEQSLAQGIRLASRGAADWLPFLYGVKAQIAFGRGN
TEEAWRFISRTFASQDVKTTAPLFRDFHETAYQISLKREDYQSAVEHLAAFNRLDSQASS
LSAQANNALLGARFDATNRELRISRLSAAKVANEVRLTKAEQQVWRLTGGITLALIAILT
ALFTLRALSRSRATIKNNNDKLTYLTQHDGLTGLLSRGYFRNLFDAEFDACMDANDQGVL
MLIDLDRFKQINDVHGHAAGDYVLVEVATRFREVAGDNAVIGRLGGDEFGLFLPHSTSIE
DARNIAANLTRRLGEVYYMSGTEMTIGASIGLTVFGDQNSSTSVLMTNADLALYEAKDRG
RGIYVEYSPKMRIELEERVSLERDLEAALANDEISISYQPIVGGGDRKIKSYEALMRWNH
PTRGNVPPSVFIPVAEDALLIERLGAWMLRKACAEAKTWDDAIKLSVNISALQLSTGEFL
TTVIEALASSGLAPNRLLLELTESIVLEMDDETERLVNNLADIGVSFVLDDFGHGYSSLN
YIEKMNFSMIKIDRDSVQTATAGSSKSQAIVTAIVSLARSLDIDVTAEGIEADDQLETMT
RLGCSSFQGYLFGAPKQSEAQSATSSDSQEAA
>W7WLE7|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MLQHRQHLTNQLGGLCQELTEGLADLSEDDSWVKGQCEVMRSQLFESDGGLTARGVRSVS
QLLLGTRERQQELRAARKAARDALKDSIHEMLDEIASLGAQTGRFSSQLDGYADEIDRAE
SLESLAGTVRQMVAESRAVHEGVSQAQARLALEHSRSAEMQARVVELEDEIRRLSDEVST
DPLTQIANRRGLQQAFETEQAKNQRAAQGEGATLAVALIDIDNFKKLNDRLGHASGDAAL
QFLTHRVAQALRPGDTLARYGGEEFVVLLPGTPLDEAQRVLTRVQRTLSAELFMSDEQGQ
VFVTFSAGVSLYRPGERLEQSLERADEALYEAKHSGKNRTCAA
>A0A094J3D1|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR2|TrEMBL
MNTEMILSFISNILLLMSLAVVYSIFPYESRIKEIYKKIIMGFVVAIIGVTIMYRQFELM
DGVLFDARAVAISVTAMFLGVIPTLIGGLAMIAYRIYLGGVGMLTGVLWIIFAATIGLFW
RHFRLKNPKFQKYNISWIELYLIGFFVQVVMILLLLTLPNTLRDEVLNAVAFALLIVFPL
GSLIISEFMLTQRFRFFQHLKTVSSEKQYKKLFSASQAMIFLIDPENGHFVDVNESAMKK
YNYTFKEFTQLSVIDVSLLNPADSKQDVIDSLSNELNHYMSRHITKDGVILDVEVYSGSM
IIDNKEYVLSSVFDVTEKLEKERQFKDVDSKLRATLLSVGEGIVVTDDNHKITLINDKAL
EILGEIKRPINKNICDIFRIYSNKSNVSFKELFHKSIEDNKIFHSDITYSLLRNDNDEEI
YVDFSISPINLEGKTNSGAILVIRDETIEEERKEQIRYISQHDYLTELYNRFYFEEQLSR
LDTKRQLPLTIIMGDVNGLKLLNDAFSHIEGDKLLIEISKILKKGIRQEDILARWGGDEF
AILLPQTSLENSKKVYSRIKDLCNKSMYQTITPSISLGCATKISEDEHVNDIIKLAEERM
YHEKLLEGKEMRNDLVRALEKRLFERSADIRIHSENMVKYADILGNELGINEDGIKVLKQ
TARLHDIGLIALDTAILTKIEPLDEREWDRIRSHSEIGSRIVLSINELQHISKDILHHHE
RFDGTGYPTGLSGNSIPYFARIISVIDAYDSMTTGRIYKEKISHKEAIEEIKRCSETQFD
PDIVKTFLKAFKG
>A0A5S9QZ01|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MAAGQSPRWLQPSHYDWLSGYLRARGMTTPVRLMMALIAGSLALSLLVLLLSSDGPRGAV
PVAMTWLAIGGGVAGVLLWAWRWPTQRQSQLFAVVSNGAIALACLAYPTPLASLNGCISF
AIIGAYIAFFHSTALVLYNFFVAAGVAMAAAIRLATSGHPALAVVDLFLVLLINIAMPLA
IQFLVRALGTDLVHAARDPLTTLLNRPAFFQATLELLAERDDTVHYLFVALLDLDNFKAV
NDTHGHHVGDAALVTVARALPVAAGPTAVIGRSGGEEFLIATLAATPDTAPLAARICQTI
AGLPVPITASVGTVCAPLTGVPTEDGDAHRLLTHLVIVADHAMYRAKRAGGNRFHHHGML
VTPADVTNTVMGSGPTPKL
>A0A377Q929|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MRKLSNPTDIARETLKQLTMRRVPPTPDHYESIYHEIAGTADNDKLHPVIKDLIVSMGSF
PRQTPELQRNIEQLYKQAGQSNWANMPALIIRSIETQGGQTELSRSWADLIRDLIRQWEL
RNPVYTPSRKQESLEKVLINFGSDANSLNEKLGALIKAWSGASVESGESPEVLSDPGDLN
NPANNSINSTSDQDNGDWRDWRDALISALSVGIEGRLSHNADLQAEAASLAVEVASVSNN
AGTQKLMPRLRKFWLRLELQNDQEIRLCDGLMGLLRLLTDNMAEVVIEDEWVRGQVAVVQ
AIMAQPLDMRVIYDAEAGLKEVLFKQGQIKHSLVETQTVLKNMIATFIDRLSVMSDSTDQ
YHSKISDYTEQIQQANDLNSIKDVLESLLGDTRSMQLDVRRSRDDLIEARAQADDAQRRI
IELENELTHVSQKVRTDQLTGALNRRGLEEIFDVELARALRSESPISIGLLDIDNFKKLN
DSQGHAAGDAALVHLVSVVKDLLRPSDSVARYGGEEFVLVLPETDINEAVSVVQRLQREL
TKRFFLNNNEKLLITFSAGVALVLPGEARDQVIERADQAMYQAKKLGKNRVEIAETPTGV
ALR
>A0A7R6W8N4|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MESMLNNIRDKIVSIGRLRTVVLITIFSILASLLITFIISITTSFQPDLIGMSITIISPA
VIAPIVSWFIVGLVINIHHLEAQMRELATYDVLTGAMSRGAFLEACQNILHYSQRNHMSL
AALYLDIDDFKSINDTYGHAGGDAVLTAFSDAIKHDKRKSDLFGRMGGEEFILMLPNTGL
EGAILFANKLRESLKDTAVSYLDASIQYTVSIGVAVSDSQNQNSVEQLIKHADNALYAAK
HSGKDRVLAL
>A0A087CYU4|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium reuteri DSM 23975|TrEMBL
MATMVSENFALTRPGTYPRKATMTRILIVEDEESYREPLVYQLTREGYDVSAAATGEEGL
ELFTKGGIDMVLLDLMLPGIDGTALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDY
VTKPYSFRELLARIRAVLRRNQSTAQSTGAVDDDIPLVCGDISMQVGQHQVTVRGETVFF
PLKEFELLEYLMQNKGRVMTRHQLIDRIWGSDYVGDTKTLDVHVKRVRSKIEEDPAHPKY
LTTVRGLGYKIDKPTE
>Q8EIJ8|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MYLRSYMGWRFWALFFCLCSPSSVSAERLASSYLKVTEEAASSRQLIRYCVDPDWLPYEA
IREGEHVGISSDYIRYIESHSNFKFSLVPTTSWSETLNFLQTGRCELTPMLNKTATREQF
LHFSHVYFHSPNVLVSLKEQPFLQGFENIGSRTLAVPKGYRLAEYIQHYYPKVKIIEVGS
EPAGLEAVLDKRADLFVGSMFSVNAYIQQTGFNHLKIAGWGGPEDELRMGVSLGHEALLP
ILNQVLDDVDELERIRIYQKWNNITVIDETNYLLIYQVIVGTLLVVFLLATRTFFISRYN
RRLTDKNEQLEALRLRLEHTNAELEFLSTHDPLTKLYNRHYFNRQFVHEHRSEISSEGAI
CLVMLDIDFFKEINDTLGHAVGDNILMELSGVLQHCVRETDVVARWGGEEFVILCHQTSI
DLVKTLCQRIAAAIKDYRFSGNVQLTCSFGIAKLVNNEPMQSCFERADKALYQAKALGRN
QICVDEFNT
>Q8E979|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MRQRRLQLMQSLFDEYIEMYAARDDKLTARFSDDFSGYAGSSDILVTSKDEWIKITRQDF
AQVPERIRIEVLDLSLQDLAEDIIVITAFFHIHLPVPDSILSQETARLMLVFQQESKDWK
IVHSGISIPYGIAKKGEIYPMTSLEERNRELESIIQARTYELAEANNRLEKLSNTDGLTN
IGNRRLFDQMLQKEWSRGQRNNTPLSLIMLDIDHFKLFNDHYGHLAGDDCLKMLANGLSQ
SGRRAGELVARYGGEEFVILLPNTDLQTALDTAKHVHQLIQSLAIPHIKTNLGIVTVSVG
VACLLPSDKHNALELVHQADTALYLAKSAGRNCIRSAPPNGTQI
>A0A1S8TAT0|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MVELRKIVVFAAVTFLFIYMLWINLKVLKNFGQKKLLSAFMISGFGLISVASFFDMISNL
LNINIIHNVITTCFTAGAIVFGAYMILWSNHIVKIIFKLNKSANKDAMTGLYNRKGFEEL
FKRKSKTQKFFYIIVFDLDKTKMINDNFGHQKGDKYITDSATIIKEEIGKNGFIGRTGGD
EFVAFLGNVSEKEVEKIIFYIKDRVTKIFKKEKTQISIGYAVYGRDGRDLGQLMRIADKR
MYNDKKIKNDYKVYF
>Q8E936|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MGNHVWNDKKKFIWLLSVLLLVAFLVTSGISYKVAHDSLSQQIESNTLPLTSDNIYSEIQ
QDLLRPIFISSLMAQDTFVRDWTLNHEQEPEKLIRYLKEIQDKYDTVTSFFISEQSRNYY
HSSGVLKKIQDVEPNDAWYFRVRSLPESEHYEINIDADTADRTKTTVFVNYKVFDFESKF
IGVTGVGLAVEKVKALIELYQKRYNRRVFFTDRQGNVTLHGDEYDGANSLQASTGLEQLA
TRILTSPSAAFSYQRNGKTVYLNSRLVPEFKWYLVVEQEDAPQEQELLNTFWGNLALSLV
VTIGILFISNMTLGRYQRKLEIMASTDKLTGAANRQVFEEYFHQALDKAKLSQTSISILL
IDIDHFKKVNDSYGHSVGDLVLKTVTNLLRSQLKPQDILCRWGGEEFLVLLPEMDLSRAA
ELAERFRDSISQRELKVNGVHIAITVSIGVAEYQKLEPAEDLIKRADLALYQAKEAGRNQ
VVLNQ
>A0A5A9BZ85|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITSLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQGHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEAIEEQAFRAGLVDPALSKALDRRVFSEFFQNAAPAVANKGLSIALPLSAAGLLNTELI
DELLEHLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A6A7SE08|diguanylate cyclase|EC 2.7.7.65|wastewater metagenome|TrEMBL
MPSAPWRCCSVAAPDGRARRAGPARTAGACARAEAKIAELRRRLAEERNRGATDALTGIY
NRKAFQERFAVELARRQRYGRRLSLIILDIDHFKGVNDAYGHVTGDRILTAVASRLQAEV
RAIDLLARYGGEEFVVLLPETDLQQARHTAGKLLARIRDEHFQTGEHKIGITISAGVTEV
RSDDTAARALERSDAGLYAAKNGGRNRIGVSGD
>A0A5H7S5F5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Wentworth|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A173VNM6|diguanylate cyclase|EC 2.7.7.65|Eubacterium ramulus|TrEMBL
MKKKTVTLKDYIMAISIFLIALVVGIFIFYSGVQHSIAKNSQERISTNVSRQSEHLRTIF
DINYQYLNEIAWQIGKSEPLISQNNIDRLEAIVEKTDLERAALIEPDGTAHYDNGVVKNL
SYRRYFKEAMSGKETLSDPLESSVDQQTRVVLGVPIYNSDNEIIGILGGSCNVTLLSHML
FDDLFYGEGDTLVVKQDGTIIAQEEGDSQQKREISYGGNLLNYYEEKNINQTQTLNMLKS
DFKEGKEGLVQLGLDDTSKSDYYLAYTPLGMNDWMICYIVPVKAAQKSYSFIRKYEAVFM
LAFCVLVTVLIIYIVRKNSADKAELLRYTQRDALTGLYNKDTTQRLIQNIVQEEAGQHAF
IILDIDYFKSVNDNFGHIVGDKVLQTFGRFLQSQFREYDVVGRIGGDEFVILMCNLANTD
VVEIKIQNLLKQVGSIRVEEMGEQKMTISVGIAFAPQHGSSFMDLYRKADHALYQTKRAG
KNGYSLYQWEKV
>A0A087CNM0|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium psychraerophilum|TrEMBL
MTRILIVEDEESYREPLVYQLNREGYEVSAAATGEEGLDIFTKGGVDLVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKGTEIDKVVGLEIGADDYVTKPYSFRELLARVRAVLRRNK
VVDADGAATTGDDMPLVCGKISMMVGEHSVMVDGETVFFPLKEFELLEYLMQNKGRVLTR
HQLIDRIWGSDYVGDTKTLDVHVKRVRSKIEQDTAHPQYLTTVRGLGYKIDEPTAE
>A0A5C5VUF4|diguanylate cyclase|EC 2.7.7.65|Phycisphaerae bacterium RAS1|TrEMBL
MAKTDVHLNVVQASDSDWCHELPDSVIEARRLASLDSFLDDAALGFHWSILDSLEDGVYI
TDLDRRIRYWSRSAERITGFAAEEVLGHSCSDKILRHMNAEGVCLCEAGCPLRAVMGDGR
TRSANVFLHHKAGHRVPVHVWGVAIRDLTGTVIGAFETFSDTTETCAAIERVHALENVAF
VDALTGVPNRRSFESEFAGRLATLRHGGPAFGLVLCDIDHFKRFNDEHGHDVGDAVLTMV
ARTLRHACRSGDMMARWGGEEFVILTGDAVGERVRAMAERFRSVVEHSWLDRNGLMLQVT
ISLGATIAGPEDDQGTLFKRVDELLYASKQAGRNRVTM
>A0A7U3LX32|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQVWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSADEKGNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>G5NBE7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Inverness str. R8-3668|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVVSLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1S7QWW9|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense RV3|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDESILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISAVLGENDMVSRLGGDEFAIIQSANGDCES
DAAMLAARVVHAVSRSFGLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEPGMDMAAQHKHALEIDMKSALENQEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLIAPDRFIALAEENNFIKPLGEWVLAQACRDAMTWPKDIRLAVNLSAVQLSNDDIV
PIVDRALETSGFPAERLELEVTETVMLERDNSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPSNPMCSAIVNTVIDMAEQIGLKVTAEGVENREQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVITPITQDEFGDIGRPTQETYCPPQKAI
>A0A1E2RV90|diguanylate cyclase|EC 2.7.7.65|Methyloligella halotolerans|TrEMBL
MAISIVLCGSDLVRGMRPHRLRRSATSLSAYSCNPGRTGGCRQWLVILGFWLFWLGLRRF
YDVTSGWTLAISATVLCVLLTVALYESAEARALIYAIGQSIPMVLSIAFLLQRSSRAAGA
IMSCIGIGIGLAGHSVVVAMNVALAVGQPPVIAMAAIVSISMLSVIFSGVLWNFGFAVMT
IERLRDEVSALAHIDPLTGLWNRRKFDEQLTFENARSARNGRPYALLLMDLDHFKSVNDR
LGHRGGDASLVHFARVAKSCLRKTDVLARLGGDEFCVLMAETSDSEAHA
>A0A8B6M938|diguanylate cyclase|EC 2.7.7.65|Methylocella tundrae|TrEMBL
MTARVLVVDDILPNLKLLEARLTAEYFDVLTCTNGPTALSICARGDCDIVLLDVMMPGMS
GFEVCRRLKADPATAHIPIVMVTALDQPSDRLTGLEAGADDFLIKPIDEVALLARVRSLA
RLRLALDELRTRAMRAAQLGINNPLASVMDENGSGGRILVVDDRRSSSETVTGALRALHD
VELEPDALEALVEGAAGRYDLFIVSLSLNAYDGLRLCSQIRSVEATRHIPILAIAEPEDR
AKILRCLDLGVNDYLLRPIDRNELIARVRTQLRRKRYADGLRQNVEASIEMAVVDALTGL
HNRRYLDGALAALLEEAKRKAKPLTLMMFDIDHFKTVNDVHGHEAGDQLLQNLAARIKGL
IRSADLFCRLSGDEFVILMPETRLDVAARVAERVRAGVESQGIPVEARERPLSVTISIGL
AESAQNAADLLRRADKALYRSKQSGRNRVFIDAAAPVRLERMTGLRVVRSS
>A0A0Q0JLI0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MVAIVVSIVSSMLSYYSGFKEKKNTNYLLVKQLAQTMEKTAAIAAYLNDKELSQEIVNGL
ISNDLVQGASLQGETNAQGEIALFIANGTINKQKEAVSVKLVHPFLEGAYIGGLSIYPDD
KFIQQQAQAALKKEFILMLIQSIVIAFFVSLVVQRWLTQPIQNLTDSFAKINPSEPETLK
MLTFKQGKRDEISRLTHGINALMHELHLTISNEQTLRKKTQALEAKFRLIFEQASAGICL
LDDKNTITTFNPAFEHYFTVPGEKELPTLHFPELLGNVDELQSLLVAIRSAQNPPQTTLD
IECKVGHKTLWFHCLFVRLTDQRENKRHSHPQQLVEVILHDVTDRAERELQTRFEADHDP
LTGLLNRRAGEKRLNKALQECTEHNQHLVLMMIDLDKFKPINDTYGHEAGDKVLIETAHR
FKTLFHEKNDMCIRLGGDEFIVARLVTFYDKAATHQQAITLLNELQQAITIAPSKTCAIG
ASIGIAIAPTDGTQLHQLMHNGDKTLYHVKETGRGKVAFYEDIKN
>A0A0Q0MYQ7|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MKANNCGHEWIINLTQQEEESDLDTSLVQIIGDLLEVENFAIYINKHFSAQLPPTLINSD
TRLEVLESNEALALLNKVTQNKIRVSRALGVVTTYVPVYYFGKVIGILLIETTTELAQTT
TMLAVHILNIYANQLGLLHKSRLDPLTELLNRQTFDKKVIEIVSGKGFLLPRDDTNEKRR
WYLAIADIDHFKRVNDNYGHVIGDEVILLVARLLKNNFRLEDYVFRYGGEEFAVLFQTKT
EAQAHIALNRLRSNIAEYPFPQVGQLTISIGFLELASIDTVSSIVHQADMALYHSKNSGR
NKVTAYSELEVNEEVTTDNSIELF
>A0A377ZEF1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGGRIYHSVRQYQPPRCRDGDGDAQPQRGAFQPAGGQSLAAGVLLGLRRI
>A0A380BFD5|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MLDQNGLRKQKIDTLDLRYHLLLLLLPLLLIALLFWVTSPAGELPWLQWGGVSIIYFLAY
SLGYFVHQGRLGRLWQHLEQVLGINEATFELVHLSSQYETEHAFLNALLGKAVAMVDGAE
MGSIILVEPGSNKLHFESALGLDLAKLQQLNMTLEQSFEYRLTDGRCNRVVVVNDMRKIN
AQSSLSAEDQALLLSAASIPIRATLSSPIHIDGQLYAMLNLDSSLLACFSTYDRDLVAIL
TREAANAIALYQKSRQIHQLANFDCLTGLANRKYFEEQAQKWQPKTKLESMLVLLDMDNL
KKINDNLGHGAGDFALKRLATELKRSCPPPALVSRFGGDEFVLLCYGSESWLRERLQQAE
ARLAADEVAVYFSAGIAPFNGDMEYSLKLADSQMYRQKRARKGGLE
>A0A380BWC3|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MKLSSRLNILVILCITLTLVLALSLLQQRHFSQQTFQQMHKLVELQLHLDLLRSNLWLLQ
QYRDNRAVENTQRDLLRLNALLSNTQVDDEQQQQLLANLKRQSSNISTLLEHSLPKLSLI
ADDQLVSSMLLSRYNMSIQSMSEDLFRFQHYTMDRARMLQLSHLYLNGALLLAIALLVTG
FTLHTLRRFRRHLGSLKRGIRDLAKGDLHSRIRLEQQDELSELANEFNNMKQALMETTAR
KEQLQLEVEAQTRQLQQQQDRLRYLADHDDLTGALNRGAATTELENAIVRCQRQQLKAAL
LFIDLDKFKPINDNFGHSAGDAVLVEIAKRLRETLRRSDLVARIGGDEFIIWLEPINSRE
EVCAVLEKIHALGADIPWQGQQLQVGLSTGISLYPEHGDTLAELIGAADSAMYQAKQALP
QASMELALKKRYSFASPSADA
>A0A377ZXN9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPYGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A0P1IX34|diguanylate cyclase|EC 2.7.7.65|Cognatishimia activa|TrEMBL
MGEVIEPSVNKKVSMLWPVLAVLTIAAAISGAAYLPTPVVDYFLKQDILDRSELWQRRIT
LHLRDTEATFRNGTTSPEENDFLSLLPEASDVYRFKLFTADGRVFWSTRSSDLGTINEKD
YFTSIVSDGEIYYKHEPKPASEIDGLLLHSHNTAPDAIHEIAEVYVPMMQNGEFIGAIEF
YTDITKVRTLFIQRVHTALIALSALAIIVVLLIGGLIVRSNRARLNALNSKSKSERALMD
QQLHLAQEVKLLGELNEWLQSSRSLDELFEMFTKFMAYMLPDCAGSIYVYSNSRDVLDGV
SAWNGGELKRHIHPDGCWGLRRGRTYTYGVHEVDFVCEHVDEEDGEPYFCFPILAHGETV
GLMHLKKVAHADKEEFLESRKLAQMCAEQISMAIANVRMRDQLQEQSIRDPLTGLFNRRH
MIDRLRHFLMTSSDKQQNTHLVYLDLDHFKRFNDTHGHDAGDYVLRAVGEILDESCTDDE
IACRMGGEEFVVLWPRLTNEELQERITVLCSKISGLALTYQSQPLPKITASIGVATAPQH
GELPQELLRAADEAMYQAKHNGRDQVIYYRTDQNPPLAEQSQPIVTSSTSDHEERNLKSA
SKRGTTEIAAE
>A0A380AAS1|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MFSLSQTLSIFAALPDPVFILTRSGRYAAVLGGSDSRYYHDGTTLIGQYISQVIQQPKCE
WFLSQIAQALLSRRLWVVEYSLGGNDVKGLTEQGPAEPIWFEGRVQALDFQIEGEDAVVW
VASNITRRHHLELELRERCERDPLTQLYNRRKLLKLLTENLTLFQRYRTPTSILIFDLDN
LKKLNDSSGHLMGDKAIVTLGEVCLASLRTQDIASRYGGDEFVILMPHTAAEQALPIAER
LRSECARRLRALGIAAECASISGGLSEFQCSDTSIDAVVSRADGALYQAKAQGRNRIVLA
KGPECTESP
>A0A143Y0H4|diguanylate cyclase|EC 2.7.7.65|Eubacteriaceae bacterium CHKCI004|TrEMBL
MGEIREQKKISVGLWVFLLVIFSFLVISWRYSPTEHFFDEEGVYELETVWHGERQSESVD
SLPAVFAHDENGTATVYTTIDEKWMEQGNTLCFRASQEAVRVWIDGSLVLEQGNLDIGIF
GQAPSSGWVMFRLPADSGGKELRIELSSPYENYQGLLHKVYIGTKAALLFAVLHTYGLGF
AVACLLIAISVVLFLFYLLFFVRKIPGSQFLLLAVFGMLAGIWMLGESHMLQFFTGKLAA
WYNMTMIVIHLMPLPLLGIMEKLPDYSYGRICRGGRYFLMGYLIMLIGLQVSGIRDFMQM
LNISLMILLLICVGNLFLIYWEFFHNHNKKILPMVVAITIFSVFACMELTHGLINIHRAL
GSYLQVGVLAFYVVLCVFSIRTTFDLYVQGLQSEYYKKLSYVDQMTGCMNRRAFTEREDS
WVPGGNDVLLMIDLNDLKEINDVMGHHVGDVYIKKCSDAILDIFGKLGDCYRMGGDEFLF
WGTGVPEEKLEKLEEELRSRVQEACKDISPVCGVASGHAAATPEDRSVEEILKRADEKMY
ENKRYVKM
>A0A735NZ51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 16:z4,z32:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A1V5HLG8|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA124|TrEMBL
MNQKKSFSIDEFFKRLFDKWVLKCPESQANSMSYRIALLNVNRLQGIAVFLLFGVFFSLI
TDAFNIAPSLLLPFHLIYTLIIVISLFTIIFIRFFVKKKDYPLKMLKWFYHLFWLINMLL
VITVYLMDAYSSGKTASLFGFYLVLAAVPILSFWEIFLFLLLPNALMVGVWGFNILTLKE
AIYTIFIYEALALVISQATYQTFLRMLDNEIKLHQSAKKLELMSLQDPLTGLNNRFGLTR
AFNELKAGAKHNDLLFVIAIDIDFFKRFNDQHGHLVGDECLVHLANNIRTVFCDNNSAVG
RIGGDEFIILYKTTFFKEVEWKMEMMYASLDELSQLLPLEETPISLSSGIAFAELKQLTT
WTYLYEDADSLLYKIKNSGRNQFLFATKKEAE
>A0A4U9CUG8|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLINSRPLLNKVLLYLLICIIATGLIHLFASSLISRTSTASPVLLPVLTIFLLILHLTIS
CFMIMKYWCVRERLYLTAIACAFAGSALLMLGTLSGHSGWFLCSQGPMPNANDALIFFTF
RNAMMVILFTIAIVLYRFRHSPRLTKRVHALILTGCLSFTILIITLSWLYSSNHPLLNIA
LVDNLSHQFSPLWHNFIGRILVASWLITLTLLIYISRLQNIFWYSGAFFCSAYIFTLLVL
MPQSDMLYSWYHARTFEAISTLFMLFVLLCDVFTLYRHSNNKYLTSYQNSIRDPLTRLHN
RSYFYDALNAQLTKASASQPLSVIVSDLDYFKRINDSYGHVQGDKVIQFTADVLQKNVRP
QDVAARIGGEEFALLLVNTGPGDASAIAERIRLAVNERQDALPERMTISAGVFTAVDGSL
SAEECVKRGGYGNV
>A0A7S7KNE9|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MLKELFLNLTILITFNYLFTLLFKESLSYKEDRLIFQLLKGTVCGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFAIIVAGRILINFNASAIFSIAAVGVIAILSAAVL
RGKKPDHKMAFVMLLFSNVIFTLTLLFLMPEQPAGALFYYWLISVLGGMLSLYIIKHEAD
ARLLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRASQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRFLLSSSDPSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTSDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A658NXH7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. AAK_AS5|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADHSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A7Z8Z9Y7|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MNKSLWGRKLRRLSSPGHVVNFCFVVVLFFSTLLIWREIMVLEEAYVDNQHNNLENVAHE
MDGLLQFNTDRMIFFRNGMQSALETPLDFMILRKAEQEYISKRHEAIWSVALHNRRTLPV
YGVSDAFIDKDPTLSRDNTLSGNELMATLELGYLLRLTNNNRGFTERMLYVSRSGFFVST
EALTNTTQALALYSAATRSPWFTRQAQRTNPGRGVVWQTFPEEGALRDAQVVTASVPLDF
RHYWHGVLAMDFSVREMKTFLVNAAKGGQDGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
ETLSYAFSHDNKGGIRLLTRYISWEKLNNFDGVLLRIHTLQEGVRGEFGSITIALMLMWL
LFTSMLIISWLVILRMVRNMSELQTSLEWRAWHDALTRLLNRGGLFERAIAAAGECERGK
RPFAVIQLDLDFFKRVNDLHGHQSGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPN
TTLQEATAIAERIRVRINSREILLCNNTSLRISASLGVSSSEDRAEVNFENLQSIADRRL
YLAKQSGRNRVCSTG
>A0A4U9CV23|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLLKELIIFDLLATPIWVVHPFKERILYGNPASRALSGDMSLDQMRKGTFSTCPEVSLQN
YLYYFKNIAEIFEVWTINSLDGQTSIYCKTTLIKSEEYDSLILFEAVKLLEQNESINTTS
RHYQRRSNGFFSRFFMTNSAPMLLIDPHRDGRIIDANIAALRFYNYTADEMRAKHTWQIN
TLGRDVLPIMRNVASLPGGHKPLNFTHILADGSIRHVQTYAGPVVLYNIRLMLCIVHDVT
EEVHLRRELEFSASHDPLTGLLNRREFYRIVDSAAFKPTGFCLLLVDVDNFKAINDSYGH
QKGDEVLLTISRILESTVTHQDKIYRWGGEEFLLFLPERSIEMALQMAESIRLAVSGYQL
ADHPGPVTVSIGVADHQDDEEIDQLFNRVDKALYAAKKEGRNQVRLYLVEKY
>A0A7L6XQ20|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C05|TrEMBL
MNDDNFYKNHIAPDEGGYISLQHDLQRSGLRFARRVRLPRAVALGGMFFPLAATLVSQPV
AGGWWLALVGWAFVWPHLAWQIASRASDPLHREFSNFKIDAIFAGVWIGLTGVNALPSCA
LLMMMGMNLMGAGGSRLFFAGTVLMTLSTLLTLQLTGGVVSFSSTPLEGGLTLPIIILYP
LLFAWVSYQTATTLAEHKRRLKIMSTHDGMTGVFNRRHWEMLLRAEFERCRRQHCDCTLL
IIDIDHFKGINDTWGHDVGDEAIQALTRQLRMTLRSSDLIGRFGGDEFAVIMHGTPAGNA
IAAMSRVHEGLRALRLPCAPQVMVHISVGVAPLTPQFSHYREWLKSADLALYKAKHAGRN
RTEVAA
>A0A175A4G4|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] siraeum|TrEMBL
MENKSGRKNVAFCIGDLEGGKMLLQGFCKVLGDNLINVHIFNCCTCYYDGAPHNIGQTNI
FTLPNYDILDMLVIAPFYLSSSEEVIRHTIERAVEKNVPVLTIGKQYDYPNCYCIMPDYR
RQIEMITNHLIERHGIRKLNFLGGFKNHFTSDERLAGFLDALKSHNIPIEPSRIYYGNLW
SAPAIQQVEKMNEDGNLDCGAIVCANDAMASAVMIKLSELGFDMPGEIAVTGMDGTDEAN
GYITTAKILADKAGEEAANIVANLLLRGKKPAKLGIIPPNIIYGISCRCTNMQNALDLLP
KQRHDLFEELYDTRRFSIRTAAIVQELANCSTFDDASSSISATLSRIWCSNSWICICKDF
MESSLVNDSIDDIEDNCPVHRHGYCDTMKCIARYADKKPQSETEFPTSEMLPDFYEMSDK
SKVILYTPIHIRDNTLGYLAFNFYPWSSMNYLLNYLTMAMSQLLESVRRQNELYAYAKKI
DMLYITDPLTSLYNRRGFFRIYNDYAEDGVKDDCMVISVDLDNLKLINDNFGHNEGDNAI
LTMANALKSAADENDICARFGGDEYVVFGKGKGEYEMNAYIDKVNKYLSEYNLTSKKPYN
VHGSFGGCILPKGSKLHIDYYINKADSKMYVEKESHKRTRMLHDYSKDKPQTDE
>A0A2H6G029|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin11|TrEMBL
MAASKKLLRHPRLQGLFFAALVLFGGLVVMFADVQAEKKKFLNYSDLIYQGIAQRLLTAE
GVITALVTFGQDSDIDGNSADSALQDLVKTYPYIYALAKLDWVRYRERSTYEKTMQENGM
AGMLIHEYDQDKDVFVKARKRNAYLVTSMLVPMEPVTSQLLGLDLLVNDEFAEAVYLAMK
NGTVSLINSPEFLNNQSSLLMLKNTYFGRLRPESLLESEHQINGAVMLFIDQQKMVSSII
KNFPDIDFELTLLDINLSKKNGLKAVKNHENVQKVFPATVLYTQQRVIKVANRDVLLKVS
SKYSPGVIQIIIAVAVMLLIAVALRIWSTSRKQQMIASINQEKAFYDLFSERERAEVTLS
SITDAVITTDDHDNITFLNPVAEKFLGISNDDAFGKPIDDVVQLVDEQNGENLGNPLEHY
LEKIPASLGGKSTCILAMSDGQSPLSIDLSCSKLKDIQGNEMGSVIVMRDVTHERELKRQ
LSYQASHDSLTGLVNRAKFEEELKKAILTCPEDNEDAPGHVLCYMDLDQFKIVNDTCGHI
AGDALLKQLSQLLIKRVRDVDVLARLGGDEFGLLLCGCDLEDALSIADTLRLSVRQFIFR
WDGRAFDVRVSIGVVAINDPKSTHAELLSAADVACYIAKESGRDYVHAYNPEEKSVTQHH
ELMKWSQKIQDALRTDKFHLMLQTMTPLLSAQANIQAQEFLLRIRMDDGSIIMPSTFIPA
AERYGLMRDVDMWVIEHSFEVIHDVRKDTDPSVTYLFSINLSGQSVGDPEISEFIIRKIK
EYEIDPNQIMLEITETAAITNFQTALDFIARLSDIGCRFALDDFGAGLSSFGYLKRMKVD
FLKIDGQFVKGMAEDPIDRMMVNNITHLAYGLGLFVIAESVEDATLLEMLREIGVHFAQG
YHVQRPTSIEAWKKENMLKTIFMRVVR
>A0A517W629|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKDPDTDIKDVIETIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSEAAITQGPLKSRYDSYWKQSIIQSAAAEL
LATRLGNELKYDSFLIGLLQDIGHLAMLRSIPNDLLPVLEQAETQQRDMSVVETEVLGIN
HTEVGVKMMERWQMSEQFQIAIEHHHDTFEQLKALQSDPNFNLIIIISASAAIGDYFCSP
NSGLALQRLQQLMAEFYNMPIDDLHGFLEEVKFRFEEAAQIFQVNMDDIESPYEIMAKAN
EQLVQLTMKAQVDSTQAFARQAAIEEQKVKLESENKQLQSKAIHDPLTKTYNRSYFNEYF
EKELYRCARSAQPIGIIFSDIDRFKSLNDTYGHQFGDLVLQRVAQVASESTRRSDIFCRY
GGEEFVIMVNNPSENGIYELAERLRKLIENEVIEFEGKRVPVTASLGAVVGIPPRDMTGF
GERLIAEADEAMYNSKENGRNQVHVRSIISQEDNELQKLVKRSRFSRWLVTKKIFDIPTI
SKALLKCPQQETQTKIGELAVNEKLLTSNQVTEILEVQQKSGQRFGEITIEKQLLTREQV
AYLLAIQIEPPIVLGKTLISLEMLQSAETAELVKLYLSEFKASTAPMQERRGEFANS
>D5MK70|diguanylate cyclase|EC 2.7.7.65|Candidatus Methylomirabilis oxyfera|TrEMBL
MSEHCEDQSQSIVIIADGVHSTRRLRELLTRRGFSVLQASSEQEALDILAAGDTDLVMLD
AEPYVALQQRADRLAAVNRLTRVIGASFDLDEVYQTFAAEVGRLIHYDRMTLALRNDRGS
GLRVLRLAPDQPATGWPEGVAGMGEGTGIGWVMSERRPHIEYDLAESRQFIEDEALFKAG
IRSCIRLPLIVKGQVIGGLCMDSIRPDRYGESEIDLLLPLSEQLAIAIETGRLFQEVHRL
AITDELTGLFNHRHFYSQLDQDLRRNRRYGHPLSLIMLDIDLFKQYNDFHGHLAGDEALR
LTAARLKKSTRGADIVARYGGDEFGIILPETDPRQALVQAERVRSVMARDHFGGQGTPGR
NTLTVSLGVACLGPDMYKVEDLVRAADQALYCAKAAGGNQIAVSESCGLPCHSEGSGKGC
>A0A517PGX5|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLDLSKDPDTDIKDVIDTIKADPAITAKILKASNSSFF
GLRSECKGIERAVPLLGTMVVTSLALSFSLSEAAITQGPLKSRYDSYWKQSIIQSAAAEL
LATRLGNELKYDSFLIGLLQDIGHLAMLRSIPNDLLPVLEQAETQQRTTAEVETEVLGIN
HTEVGVKMMERWQMSEQFQIAIEHHHDTFEQLKALQSDPNFNLIIIISASAAIGDYFCSP
NSGLALQRLQQLMAEFYNMPMDDLHGFLEEVKYRFEEAAQIFQVNMDDIESPYEIMAKAN
EQLVQLTMKAQVDSTQAFARQAAIEEQKVKLESENKQLQSKAIHDPLTKTYNRSYFNEYF
EKELHRCARSAQPIGIIFSDIDRFKSLNDTYGHQFGDLVLQRVAKVASESTRRSDVFCRY
GGEEFVIMVNNPTENGIHELAERLRKLIENEVIEFEGKRVPVTASLGAVVGIPPRDMTGF
GERLIAEADEAMYNSKENGRNQVHVRSIISQEDNELQKLVKRSRFSRWLVTKKIFDIPTI
SKALLKCPQQETQTKIGELAVNEKLLTSNQVAEILEAQQKNGQRFGEIAIQRQLLTREQV
AYLLAIQIEPPIVLGKTLISLEMLQSAETAELVKLYLSEFKASAAPMEERRSEFANS
>A0A2H6AU53|diguanylate cyclase|EC 2.7.7.65|bacterium HR39|TrEMBL
MDHASTAFDIAERVYATCRRLGIPPTPENYLLWYTHCSGDHPALSRMIRLLEENGDPLGP
ERCRELYERFFLRSDMERTVARCGARLEQLMREVEEQLQGAGRRNEEACDRIAALGGRIA
RDGDPGEICRLAGRLLGEAKRVAAELRMLSGQMHAKAAEVATLRSSLEQARREAEQDPLT
GLANRKAYERRLRELARESMETGRLLSLVVVDIDHFKSFNDMYGHKVGDAVLRVVAEVLR
RHVRQDDLVARYGGEEFVLLLADAGLDAALAVAERIREEVGARHLRDRRTGRDLGRLTIS
AGVAEYRPGEPLEELFRRADAALYEAKRTGRNRVVAETEVSAPDAAPLP
>A0A517W8G3|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MTAIPLASLFTLSSDILICFGVGLLIAVSLGFVAGYLLGKGSTDRDFRRAKKHLQNCYQH
VEKSLETAYAACALLEKYPGPILTREQSVELNQKRSSLLDLVGRLVERKTPDPAAESASP
KTDKKKLQDFPAMQWALQPEQTHIKLPDASAFEANLEMMLLAGTETEQNSGLLLVQMNQH
EQLKDRFGLMAPTKFMKTLSRLVLHKIRDEDVICVWKSDTLAVLFPGLTVSEGQACSELI
RDAIRHHHFRLETSSPEVVVTASLAYITCVPGDSAELALERGAHALTQSQKQGRNQLIIQ
DSHSYEHKRAM
>A0A1Y5RLQ2|diguanylate cyclase|EC 2.7.7.65|Roseisalinus antarcticus|TrEMBL
MSNERTTAMWREDWAVPAVDKAEAAEPFDFANEIMDIMEQGILVWSPDGVCELHNARVFE
VLELEPGQLYIGMMREEFRDLALQRGELTEVDADASKHAIEEHLPYSFDRKLPSGRMVLT
NGRPSASGGYVVTFTDVTEARRAARDLISARAEVEAAEMRAKNVLATENARQHEARMLSL
LDEWLQSCKTLDELYMIVTRFMGRVMADTEGEIYTYSSSRDVLDGVGSWVTNKLHRNISP
DSCWSLRRGRAYQYDPKGICFVCNHLEHPPDEDYPCEYVCVPVSAHGDTVGLMHVRFDGE
TYSGTKLKDAMNFTVQCAEHISMAIANVRLRDELHEQSVRDPLTGLHNRRYFMDAMRREM
ALADRTGQTFGLISFDADKFKTFNDTQGHDAGDAVLQAIAAAVQDTLGPGEKCCRVGGEE
FTVLLPGRDLAGTWEVAEGLRGAVEAMGVRHAGASLPRITISAGIAAYPTSARNSASLLK
RADEALYAAKDEGRNRVGGMEETEAEPEHPRTGDAATPWHEPARPKPAPPAAATEGQHPT
ESPMPAAQQVGPDHAPPAPIATQSQPPPEAGAKAEGPSSPEPSGGSRPADVSAPAPPGPS
TAPSQGPSPAPAPQPAGQGGSSGGPARPGAPPSYGTHGPQGTSAPSRPPSHGGVAVRSKD
PRAGQRPPRPALGTPEPVAPTARPAQPRPPTSSSSHTPGSPSRPPPPRDPTRKG
>A0A2H6AUC2|diguanylate cyclase|EC 2.7.7.65|bacterium HR39|TrEMBL
MPLAADVAHADLLRALENERTLNALLRVAVRNEPLDVLLEECLDVLLSVSWLSVLPKGGI
FLADSERGELRLAAHRNLPPPLLGSCARVPFGHCLCGRAALAGQILHAACVDHRHEVRYA
GMQPHGHYNVPIRDGERVLGVIVLYLPEGHPADPRELAFLGAVADILALVIRHRRTVEEL
ERVCAELAVAATTDPLTGLFNRRAFVARLAEAWAEAERLGHPLALVLLDLDRFKEINDTF
GHEAGDRVLQHTARLLRARARRYDVPARIGGEEFALLLPGAGRAQGVRAAERLRADLEGT
PVDIDSAGVRVTASFGVAAHPTAEDPQELMRRADRALYAAKRAGRNRVEAA
>A0A2H6G2S3|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin11|TrEMBL
MKYPGITTQQVMFRIAVVIAVAEFFIMLGLETYPYPFSHTTGAVLDVILLVLISSPVIYF
WIINPFKRERDEAISELADMAYSDPLTGLPNRRVFLKSMEKTLAECARHHIHAALILIDL
DEFKNVNDTYGHDAGDAVLIEVGQRLQKGMRKEDVVSRVGGDEFIILIKQLNDDSDKAAK
EAMAFAEKIKLSLAAPIKYTHKRIQLDSSLGINLLGSETYKIEAEIRKADVAMYHAKRMG
KGHVVMYEASMVGRETSRN
>A0A517PS39|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MYFLIASIIEVFTNHVASGASSASVLAIASVCLLQYVVYTMKMSAVRKENAEFQQHYHDV
EEELNDVQSDRAMTLIENHILREFVAQSEFDQTIDLLLKRYVPSIREGLGLYLNRVNGEF
KVRDSRGITRNSKAVFEFDERQLKQLKTQNVIILRGQELRNSKIYQCFDEQDKPRIHKLC
LLAVYDKNAISGVFLTTNLYPDGVDEQQQIKLAKRLLVCVSRNIVKNQDYESYRFELRVT
REQLELRALADQQFKTPVIMLEEFLDRLRQLTNSSRASLFLSTPHEFSNCKSIVDCGMTL
QAGVKTRWKEHELTLVRLGLNSGENTSLSGEQLENHGVRSLIGAALVSPLITNRKRIGAI
CLTNQECQPFDERALRLISWASQFLSNTLLKVLNHANIEKQARQDGLTGLVNRRSFDELI
DNAFGRAQAAQSACSLILIDLDHFKSINDTYGHQAGDEVLRRVARILQDRIKEIRSSDNV
IAARYGGEELAILLPEIGLAGAERIAEVIRHSIETATIEFNDTRIPVTASLGLSTYTSQA
MESVQTLVAAADGALYQAKSDGRNRVCSLTSAPV
>A0A1A8XQR8|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MSTKDKSPAEQALRSQAEAIVRETGLAGQREAMSLEAMQKALHELRVHQIELQMQNEELR
RIDAARERYCELYDMAPVGYCTLSEKEVILEANLTAATLLGVVREALLMQPLSRFVFGDD
QVIYYFHRKRLIEVAEAQACELRMVKRDGAIFWARMEATIASNESGHPVFRVMLSDISDR
KQAEGRLQLAACVFSHAREGIMITTADGTIVDVNRAFTRITGYSRDEALGRNSRFLASDR
QDQAFYAAMRHDLIDDGYWSGEVWNRRKDGEVYVEMQTISAVPDVQGNIRQVVTLFSDIT
AIKRAEESLAASEELRRLFIEYAPAGLAMFDRDMRYLYTSNHWFADHGLDKRDLHGLSHY
DVFPEIPEQWKEFHRRGLAGEVLRSEGDRFERLDGSVKWVRWEIRPWYNAQRSIGGIIIF
TEDITANKKAEEVLREQEESFRLIAENLNGFVAILDADGRRLYNSPSYARLLGEREIVGS
SSFDDIHPADRERVIRAFREAVATGIGQHLEYRFLMANGSTCLLESRSGIVMDDEGRTKR
VVVVSHDITERRRADEKVQHLAFHDTLTQLPNRLTLHERLNHSMAASKRSGCYGALMFLD
LDHFKPLNDRHGHEAGDLLLIDVAARLKRCVRETDTVARFGGDEFVVLLSELHTDKDEST
LQVRRIAEKIRLSLSEPYSMIVKRDGMADHTIDHHCTVSIGVSLFISDEVSPDKLLKWAD
AAMYQAKEDGRNRIRFCLELG
>A0A1R4LG42|diguanylate cyclase|EC 2.7.7.65|Vibrio ruber DSM 16370|TrEMBL
MVRFVLIIFLMAGYCQITLAATDHHNRIPSLLTGISFFHEETLTPLSLAQAEQRFRFGEI
QHPTQDFMSFGIHRNATWIKLDVNNQTQNKQYRRLNAAQAWVDHLAVYLVNDQGLIQAWH
TGDNQVADSHLLPGVGFVFDMRIPPGKSEIFIRGQSLDPLTLPIALLDAYQSRSLDAQIH
VTSGILYGVLLALVGMNLVLYFSIKQLDTLFYSLYISCFIIVNISYNGYGFAWLYPNSLL
IENHLTLIMMIFHGVSGLVFVSNFLRIHQTAPRLNRLLLIYSGLGILVMLFLIGFSMHLW
ATKFAFKFLSLTTMIMILLGVLNLNKTKDTRYFLIAVICSMLGLLITTLSVWGIIPYNYY
SYNGAVFGVVLEAIILAVIVAYRLKDVEQQRITAEYLSSYDPLTNLFNRRSFMAAGHQCI
QQSNRTQRPLSFVMLDIDHFKKINDTHGHHIGDLALIHIAGLLKRDTRKHDIIARWGGEE
IVILLPDTNPEQALAYTENLRLIIAQTPFRHEEQDIQITASFGIATRLNDESLETLYRLA
DKRLYQAKQQGRNRVEPQNKDFPALETPDLH
>A0A370NMW4|diguanylate cyclase|EC 2.7.7.65|Cupriavidus lacunae|TrEMBL
MTPDTAPPSHQAAPGPSAPQRRWLPLLLAGAGFFVLAAAALWLARLPGTVAAVWLPNAFG
LGLLLHRPRAEGPWLLAGMLGASVLANHAAGDSVGIALMLTGANLAEMLFALGLLRRLDR
HAFLGRHGPLAAFAVMLAVGGILAPAVGATGGAAAIAATQGTSFASVWWTWWQADALGMA
LLLPMMLSMTAVRVRAAIARPVLAPQAGALALCLVIGAFAQWQGHDPFAVMSLPLVLVAL
AGNPFATALLTLVATLCLQALMLLTHRHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
SSDKRFRQAMEHSAIGMALVDMDGGWQTVNRSITELLGYSADELRELSYQQLTHPDDLTG
DLRQVANLLSGKIESYRLEKRYRHKDGHYRWVLLAVSLVRDEQTGEPQHFITQVEDIHAR
KLAQQELERLSRRIQLAVEAGGVGIWERDLISTDITWDARMHALHGTDPANGAPLAEQWT
ALLHPEDVSRVNREMRRAIRGEAPYDTEYRIVRPGGEVRHVRAMAMVARTPDGTAHALIG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDATMHVTFMNPIAEQLTGWTMASA
TGLPLERVFRIVDEATGEPIPSPVEACLRTITPAYLQDGAVLQSLTGERHDVQDSAAPVL
TARGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
HAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYMIRHHVRPDDVLARLGGDEFALLLKDC
TVDQAEQVCQGVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPEADEDGDP
RHIEILVRMVDEHGELIMPGAFIPAAERYDLMGHVDRWVIRNVLRGYGERLGAVPGLSVS
INLSANSLGEPFLLPFLHAELEASALPASRIRLEITETALINNMAAANRLVVEMRRAGCT
VSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVRTVA
EWVEDERTLDALRAIGVDYAQGYVIGRPVALDVFLAGCQQRDTQAS
>A0A5E4XNR1|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MKRNLPSASPLTGRLRLQNLAIVFVVIVLCAGLLTLAWRSYQRASDAAQGFDALRATLLA
MEKASAERGPANAVLGADLPLPQEAVTALRTAREATNSQLDRLLYVLSSDHCERCGGSLR
AVEKARLDLAAASANVDLLVQRPREMRSDAAVRDAVDRMIRVIADFTPVASTRIDIIARG
APEALHYIILARLAADLREYAGQLGSQFTASLTTGQTLTEADQRAMERILGRIEQLREMI
TSRLSDPSELPAGIVSALNTQYFGAGLHYVATVRTLASQPKPAPFSTATFARQYVPTMRS
ITDFRDAMLTLAQEKVEARRTSALHLLTATAVVEIAVVLLIYLVMRNFRRNVVYPLETAA
GVIDALAKGDPHMAVVGEELSMHRPEVRTMFKALRILQLSGIELMQLRRERARLVGELEM
LSDTDPLTRLLNWRAFERHARALCAIPAPGRVALIKFDIDNFTQINATWGHHVGDDVLRR
VSAVCLNTCQPGDVIGRLGADAFVVLARVLDESRAQQFAELLRGRIEASTLPLGDGEVLT
VSASFGIAMAEPATDDIDPAGERAVVSSAVADISALLSQAERQLRAARQAGAGA
>A0A1E3WPH3|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MILTLEKKWLYPLITFTVMALIALCVGYFSYLSQQRYSQTIFENLAERQTEVLAEFIGSD
LDHIGAGANFFHATDRDEWDHFPIFARQVVGASQTLVTLQWMERVEEAQVDQFVANARLQ
YPNYQIYTIPKGGEKTLGYIMPAEAPIFAARDIYPRNAANESVLGFYSSRPRFQLVVDNM
RIHHKPSLSDKVRLIQDGLDSSLERDGILVYHPVFDMETNQCLIGVVIGVIRTSHYFEGL
MVRTAAEQKLEVKVVDLGFDAEDDPVLFESDNWATTDGLEVRKVLDLPNRQWAIYFRLGD
KVTVNDLLIVHGILFGGFVIACLLSYIAYLQVRAKSNLEHQLAQRTKELQFLVEHDSLTG
LYSRHAFNQFIAAMVEEDRRFTLISFDVDKFKLVNDNFGHAGGDKMLIHVARTVEQCLEP
GDIFIRLGGDEFGIISNVIERDTLNTYLNLICSTVFTSNIQIAEQAVCCSLSIGAAIRDH
DSVEQLIHSADAQMYKSKNAGRNTVSIAE
>A0A1C7F708|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MVSHREEWLDFLLNSLPDHVFILDPNGRYIDSYGGSHYAPRFDAKRYIDLCLDQIFSAAK
AAEMQGYIDQVIHQQKTLVVRYSVQLQDHLLLSIDDIQDFELPEESWFEAIINYVQPSAR
NHTAQVMWSVRNITKAHQLEKELKKLSETDELTGVLNRRAFMLELEQDFQQQSANNAHLT
CLMVDIDHFKDINDMVGHLSGDLVITQVATICKNVIRGSDYIGRLGGEEFGIILSHTNAI
QAFDIAERIRLSINSTPCHVDGHEIYPTVSIGIAELNSDSQSVKALLVEADKAMYYSKRT
GRDQVTIYHPNLPDLKTNSTSKARILKAS
>A0A5W2ACE4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pretoria|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A450CJJ7|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAIFDEFNLSKEIESDLVN
CWSKIVYPDDVQIWKDDIQELLDGKKGEHNLEYRLINKYEEIVWISCRGKVYVSDDPKTI
LLVGRIKNIGEKNKFDSITGTWNREQFEHRMNYLIKEKIYKNGAMFIMDVDNFKNINEKY
GHSYGDKVLRAIATEVLEYIPKDVRLYRLDGDEFAFFYPMCTKETIEKIYEKIHMYTNTQ
HEIESNKYYCTITAGVAMYPEDGDNYLDLFKHADIALDIAKISGKNRIKFFSQELYENKL
KVISMQQKLRECVENNFNDFELFFQPQVNAVTKEVIGAEVLLRWHSSTYGEVSPVEFIPI
LEQSNLIIPVGKWIIKEAVKQCKEWHKINPDFKISVNVSYIQLKEDFFRDFIVECLVEYQ
LRPEFLILELTENCWIPDINLLNDKFISLKGIGVYIAIDDFGTGYSSLNYLKELSVNIIK
IERSFVKNITYNSYEYTFLEYIIKLAHIINLKVCVEGIESYEEYDIVKSLGVDIIQGFLF
GRPVSASEFYKFQLSK
>A0A2T2Y856|diguanylate cyclase|EC 2.7.7.65|Kluyvera genomosp. 2|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLLDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEASQIDTLRTAERIRSRVEKTKIAAPDGNDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A7W5XT56|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK612|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGLKALAICASTQVDLILLDIMMPGMD
GFEVCERLKSDPRTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELHMRNETARNFGIGDLMRSGEGRSEEAGQVLLVDGRANSQERIIRTLKPIAQ
VIAMSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
DMIVRALDLGVNDYIVRPIDPNELVARCLTQIRRKRYNDRLRASVQQTIELAVTDALTGL
HNRRYLDNHLKVLFDRSLARGRPLSILITDIDRFKTVNDTHGHDAGDEVLKEFAARIRST
VRGADLACRYGGEEFVVVMPDTPADIAAAVAERLRAAVENMPVRLRDTGVALNITASFGI
SCRLETIDTPEQLMKQADLALYEAKRAGRNRVVASAA
>A0A4P8YGF0|diguanylate cyclase|EC 2.7.7.65|Jejubacter calystegiae|TrEMBL
MVNGCKPNTNINEIDRALGELNLAIKNHYEWAGKLLRLELLGGEPDDDLIHIESHKRCHF
SYWLAAQAEMDDLQVELISEINRWHEIVHHQARLLINAIIASTVTSELLDDYLKAQQEFI
QAIDSYKVYLFSLRNLHDTLTGLPLRQMLYSDFALRRQRCRREDKQLWLLMMDIDRFKRI
NDTWGHNAGDEVLRSVALTLKAGTRRKEGIYRFGGEEFVMLLEADNEREAARAGARICRY
LEQRPIKRNGEEIQVTVTGGLTPILEDESLHEAIGRADKAMYFGKTAGRNRCIVTGPKGE
FINVS
>A0A0S3PWW0|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MRDASVLVLQAITYFCALSLPFFYRRRIGLGVFICALGVLHFLETYLAAVFFIQTSLGLI
TPGSTVLFSGKLAMFLLLYVKEDAETVRQPIYGLLFGNVMVIVLALLLRLYDNVAVLPGY
NPDFRFVDQMGLLMIWGTLLLFIDIILLIILYEKLERWIAETIVGRFFISLAIVLTLDQL
AFFVGLHLLSGVPFSALFAGLVAKLAMAAIYSMLIGLYLAIAEPETAAPSNLRVSDVFDR
LTYRHRYENLLQNVGRDGLTGLSNRSQLDIIGRDMIASAKTRGASLSLMMIDVDRFKEIN
DTHGHAAGDAALRDVSQIIASQKRDFDMAFRYGGDEFAVLCVGDDQAAVRLAERISNAFA
SISGFTLSIGVASYPHHAADLSTLLDSADKALYAAKRGGRDQICVA
>A0A212KLU3|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MGLEPDSVSRFRSHRFATFSYVTALALIASLSIGTHALIDSIVREQQTTAKVINVAGRQR
MLSQRIAGLGLEVSILPPGVERARALDDLGESVALMERSYRALRRGDAVFGMASADSERL
RRLYDQPPVELGAHLDRFLGHARDFLANARLGIADPESLAAVRAAARRDLVDALDVAVIA
YQDDSEDAIRRLRHVLFAVLGGMLVTLVAEAVLIFRPLFRRLEERERTLVDLAADLDQAL
TLSTAELRLAGNVIQHTAEGIVVIDADGLILSVNPACCDLIGLSRAELLGQPVAILRSGR
HESAFYDEVWSAVRATGGWAGELWMRRRDSVFLAYMTINPLSPDLADTGAASVAIFADIT
ALREKDETIEHMIFHDALTGLPNRDLVWERLSGIAARCAADRETRAVMSLDFDRFKGVND
DFGQDAGDAVLRQAAARLLAMLPAADTVARIGADEFVILLEPRPDAASLAALASRIVSDL
ARPYPVAGREIRLGVSAGVALCPGDGEGEAELLRQAGGARLVAKQQGGGAQFYRPDIDQA
LRRRLRVEAALRAAVAAEGFRLEFQPKLVLADGVVEGVEALIRWRDPELGPVSPAVFVPI
AEDIGAIGAIGEWVLREACHAALSLRRHGFEVPVAANVSAKQLLAGDLPERVAALLAETG
APAGLLEIELTESSVISDPESTVAQLARLRGMGVRVALDDFGTGYSSLSYLRNLPVDFVK
IDRSFVSHLETAANDVTVARGIVALGHALGLRIIAEGIETEGQAAVLREMGCDVGQGYLY
ARPLPEIELLGWLAARRAPALAHGID
>A0A1I9YNW6|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sprentiae WSM5005|TrEMBL
MNVSVESLSDLVVERVGFGIFVLDRELNVLMWNRFMQDHSGLSAEQVVGRSIYLNFPELP
RVWLSRKIESVFQLGSFAFSSWEQRPYLFKFDHDRPITGGVDFMQQDCTFMPLMRDREVV
AVCVTISDVTHVSIVQREREEAVAKLQEYANLDGLTGIANRRFFEARLSDEFTRWQRYGG
DMSMLLFDLDHFKKINDQFGHGVGDTVLRVMAQRVAGVVRAQDTFGRFGGEEFALLLPCT
PLDDAMLVAEKIRRVIEETPVELIGTSVPVTASLGGASARHGVPAYDVLINEADAALYSA
KRQGRNCAVAFRLAGA
>A0A173ZRT4|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKKKRIEQNEIKRYFLIIAAFLSFMILSLLFFLSWLQQDVEVSSRKTVATNVERQSYHLK
SVLDIQFNYLTGMASYMGEGEDLFCQENKRLIQSIVKEQDLDLIGIMKADGDTYYNNGAR
KNVKNRGYFKKVMQGQKIMSPPIESKVDGRTKVILAVPIYRNGKVTGALGASYNVGALNQ
MLFNDIYDGIGFSMIIDTSGKIISCDSGLSYRKIGINDNVYDFYTKSGEVAEKTMKSAKA
NIKKQKSGILVLKEKNAMSYLAYEPLHINNWMLCYLVPQSKAQEEFQFIGNKEVILFAVI
GVGVITFFILIFQRTSMKQKKMREIASRDGLTQLYNKAGTEQRIKEWLHSDRSKAGAVLM
MMDVDYFKQINDTYGHAVGDRVLYKVGHLLKSSFRENDIVGRIGGDEFLIFMEGITSEEF
AVRRMENLQQYLRELPIEELEEHTLTCSMGAAFMPKDGTTFGELYKHADEALYTTKRNGR
DGFRIYHEVEEKEV
>A0A1E3GYE7|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MIEHVEDPRGLVDDLVALVRPGGLIAIGAPAHPSVLTEIPNNLLNGPPHHFSWWNADAFA
ALASLAGLEVIENETLPASPYGSAVGWMDRLVPVRTKGAGGPPYFAHRWLWHAALALSVP
LALLANRLFDPPARARGFDASCSCASPPEGHPPPQRPAGPRRELVHRILQSRRRRTKPPR
EPGSTAFESNAPLGVQTCTRQSPYRWSPERSGNPRMHERTGRLGIYGFLHRLPLPGSYRF
KLFFVCFVGSHVPLVAALVHTLFFAGDDSGPVTMLLVLLGATLAGTVFTLTMLEGALQPV
RLAAESLRAYLHDRRLPALPESYEDEAGQLMRAVQQVTTWLDHELRRNEDLATRDPLTGL
ANRRAFEDFMMAAFVECRMRDVPFTLLIADIDQFKSVNDTFGHDVGDAAVAAVGAVLADI
GHPEAFAARLGGDEFVLALPATTERQAADVAERLRRRLRAQPCPGLSGRPLTLSIGLATL
RDGETLPQQMLRRADKALYGAKRSGRDRVTLAR
>A0A1E3H0W0|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MAFSPSATNLPILTTIMVLLGCFFALAWLRDRRQLYNFSWTIAYLLGAAAGVLLAMRGTV
PDLLSIGAANTVALLANGVFWCGIREFEGRPVRPFLAALPAGGWMALCFVPAFYETYPLR
VAYVALAVAVFGIVCGREIWRNRRRDPLPSRVLALVVFSTHGAFHLVIVALAVAQPHRFG
ASLQDSPWFGLMVFERVIQIVALGVILIGLGKERAERDMHRLAMTDMLTGLANRRAFFSR
AEAALAQTRHGAFILFDLDFFKAINDSHGHIAGDRALAAFARALEIHAGEGAVLGRLGGE
EFGCLLPAGDIGAAADLADRVRDYIAAMRMESNGRVFRMTVSAGVAEIGEGGLDGVYARA
DAALYLAKSRGRNRVELDDAPVDLAAAASDRVRLLGA
>A0A379SU64|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MSKPSQHVFVTVPHPLLRLVSLGLVAFVFTLFSLALSRFGTQLAPLWFPTSIMMVAFYRH
AGRLWPGIAVACSLGSIGASLTLFPAASLNFSWMAINIIEAVTGALLLRKLLPRYNPLQN
LNDWFRLAIGSAVIPPLLGGLLFWLMAPEAVASKASLIWVLSEAIGALALAPLGLLFKPH
YLLRHRDPHLLLETLLTLVITLALSWLAMRYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
ATVIMVSLMLANDPTLLATPKIDVMVNMPWLPFLMILLPANMMTMVMYAFRTERKHITES
EARFRNAMEYSAIGMALVGTEGQWLQVNKSLSHFLGYSQDELRAMTFQQLTWPEDLNNDL
EQLNMLVRGDINSYSMEKRYYTRSGEVVWALLAVSLVRHKDNQPLYFIAQIEDINDLKQS
EQENQRLMERITLANEALFQEKERLHITLDSIGEAVVCIDVDMNITFMNPIAEKMSGWRQ
EDALGAPLLTVLRITSGDKGPLLEDIYRADRSRSDMEQEIVLHCHNGGSYDIHYSITPLS
TLDGDKIGSVLVIQDVTESRKMLRQLSYSATHDALTHLANRASFEKQLQQRLQTIQESPQ
HHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSGDLLARLGGDEFGLLLPDC
NSDSARFIVTRLINAVNEYHFMWEGRLHRIGASAGITMINKHNCQLTEVVSQADIACYAA
KNSGRSRLTVYEPQDVLTPSRE
>A0A7H4N8Q2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHVAELLSDNIRSSDYIFRYGGEEFLL
VLVETRRGGSLYYP
>A0A8F7UYK6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDIGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A162TDJ3|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MKKVFVKVIVVFLIITVGIMTFLDEERIANLKAHKGILNLNQWNFEKQGIVNLDGQWEIY
DNKLLEPKELSGEKPDGYFNIPGSLKKELNGRTTGYMTLRLKIYAKDEIVYGLRISRLLS
ASKVWVNGILQGQAGKVGTSFQDEQAIYLPVYSYFPAESGLIDIVIEVSNFRDVFPVIKS
MEFGTKTQIMNRFLLSVFIDSIIIGALLIIQLLFLFLYKRRRENKAFLYFAILCLFIQLR
CLFLNERIIVHVFPNMPYELLSKTAALTYYLWIPVYVIFLKEQFISLSKKIILVSSIFGV
AFGIICLITNNVFYDRLAFSGEAILFIILLMILRFLSEKVRLKEKNSLISLIAYIILIVT
AFNDILVSNGMIYRKYLFQIGMFMFAVLETYILSVKYSDEINKSQELEAKNRIIYEKSIR
DSLTGVYNRNYIDKIIDDMMDNYLNNNKKFSVIMFDIDHFKSINDSYGHLYGDKVIIKVA
ELIKENLRYMDYVGRYGGEEFIVILSNTDVKKAFEIADNIRHSIEDFVWEHKSKITVSGG
VYENISDKKTEVIENADKLLYLAKARGRNQVCSPLIQDIASSGKP
>A0A1Z5HZQ5|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MNKSGLVIRLAVVIVFTAVIVGLITTQLFYRYTFLNEQRLGEQSIKQLYNTVSPTASIAS
YLGDEELAKEVINGLISNDLITAAAIKTDVLMVKSDNYQESAAMLEFILFSPFQPERSVG
VLFVKANEKYLVEKANNISATNTIVVAVEALIITIISIFVTYYVITRPILSISKALHAIS
PGTRERINKPLSHQKSEIGQLADDVNSLLAKAEQQMLREKSLRSEVQVLESRFRMLFENA
TSAIVLVEPQGDILLYNQVFEQLIEKLKLPLKKNYGNYLQDLFIMKKDLHEQIRIAFTND
ESAVAELELISYQEEKIWVQIVVTQLITDDFQENYQITLHDISKRKQQISLLAQKANYDS
LTKLLNRQAAEQHLKQLIFTRVPFALIMMDLNDFKPINDIFGHDAGDEVLIHVASQLMKS
LRKDDILSRWGGDEFVIILPNAIKKEVTNVCAKLAAQLSKPHHLSQYNKSVSVTASMGVS
FYPDDKLELLELIRAADKAMYQVKREKSTNKELYLAFSSDLAKQANDSTSA
>A0A379N0J9|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MPVATPERTTPLQITTDPEIAPSGPRLVERLNGGPAGNGWSGHNFSLETIPLLREALMLL
PQPLMVTDPEMRLALTNHAWQDTFPVAAADMLPLAPVQPIIERIAASGEYGPGSSMRHAA
FRKEAIRSGHRFQLERQRPGGVHLLVAGCPMPGGGYLTLLTDISAQRQSPDALALRKELE
ALRTANRELDRLAATDPLLGIANRRGLLRVAMAEAARLGREGGSCALMLLDLDHFKAIND
RHGHAGGDLVLKAVATTLRGALREGDHLARHGGEELVALAPRAGASQGHEIAERLREALA
HTPVALPTATLGVTASVGVTAWQAGEGFEEALMRADQGLYLAKRAGRNRVVSVPA
>A0A3D3ATC5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp|TrEMBL
MNNECMAMLAEQWKLICQNYSSDDLLHAFQFIQDHSLVLVEEFYKNMLLEKEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGIREIQRK
MFELLSLNPQPNMLTTCSYIVQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
QIYQIDTLNQAVLECTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISRE
>A0A127N0H3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MRHLWCLLFLLLGCASAAAQPLVLDERASGRWLNDGLMLLEDPGARLDLQQAREQDAAFV
PAKGRTSVGQSPNPWWLRLDLERQATPPGGWWLEVDAVNLLDLRLYLPDGQGGYRELRSG
EAVPFAEGRDRSYRRPVFHLPAGEGPLRLYLRSLDPAGNSFPLRIWSQDDLQDHRAETNL
FLGGVYGLIAALLLYNLFILVSLRDRAYFWYVLTTGFALLFSMGMTGHAFELLWPGDAVP
WWLNRITLPSLWGLCVTRFTQTLLQTRRNVPWAHHMLTLNCLLYVASVLLNVFVGRSEAG
WVLATTTFVGIPAALGAAITRSLQGSLPARLYLVGFGLVLSSVSISVMRALGVVQPSPTT
AYLFPVSVAMESILFSFALTSRIQELKREKAQALEQANREKSARMTLLQSAQNDLAQAVA
ARTAELTQSNRLLLEREAQLRHAAHNDPLTGLPNRRYLVEHAEQALQQAQQNGESLALML
IDLDHFKPINDTHGHDAGDFMLQHVGHRLRQCVRSSDCVARLGGDEFAALVSGPDAEGHA
REIAVRLLSELSRPVHFDRLELSVTPSIGVAIYPRHALQFAKLYKAADQALYQVKGSGRA
SYALAGEDAGNGDFWLETLKTSDRLV
>H6LK77|diguanylate cyclase|EC 2.7.7.65|Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)|TrEMBL
MMKFLKLDRQSIVFRLIVLIISMIIGQAVLLSLFLIVGGVLSQAEQNAYNSFSEKVSNRK
DYLQREMTSRWTNISPYGKEISLQYNADKNPDQFLSDISTSLITMLRSTQATGVFVILNS
ATDEKPALYIRDYDPLLNDYTSSDLYYVYGSANLANNLKIPLDQMWKYRIDLSTMNADFY
NQPASKVSLSTDPTLLGYWSLPFKLTPRDGPIITYSQPLFDKNNQFIGVIGVELSEQYLS
KYLPGTDLQTKDSYGYLLGFRESHSQQLETILLTKSIQERFTHEGEPLNYSSIDADHSIF
LLKNSNSQSKLYLAVENLDLYNTNTPFESNQWYLIGIMNESNLLAYVYRIRNILIISFIA
SVIIGVLCTYFISYRFTKPIAAVARKVKESTAVKAIKLEHIKLSEVDELLDAIQITSNML
LETSGRMSRIVEMVGLPLGVFEYRDDSEAVFFTDQIPILLSLDDTDTEIIMANKTLFIAL
IDKLLSTPEESEENVYYINQIPEKWLRIKHTQNDHATIGVILDMTDEMSEKKKILVDRDT
DPLTGIYNRKAMQLQIEATLANRDLKKVSALLMFDLDNLKFINDTYGHKWGDTYIKHAVR
HLSEIEPSRQILGRRSGDEFTLFLYNFNSQEEIRSCLKDFFQNLIDNQLEFPDGIIKPIT
ISAGLTWINETELTYDDYLQQADELLYKAKRNHKGYYCEP
>A0A5P2MCA0|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MMRNTMEIDAILIELNKSIDAHYKWLVNMFRCAVTSNATQPDIMGDNAHFVCQFGQWLNN
QSLRNEDDCSYVNKINTVHEKMHLSGKDLLLAILEKRSYPWHFTKFEDALLAFTSAVMDY
KIYLLSIRSNIDILTGLPGRRMLDESFDQQLIDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDVVLRALAANFLAWTRYDEQAYRYGGEEFIIIIRTKTDEQARQAGLRLCQLVGQQKIPY
ADGEIAITVTGGITRAQRDEKLDTALGRADRAMYQGKQSGRNRCMFMDEREQITLVNASD
GLSFHLSA
>A0A2N7RTH2|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MHKFSLPAILRLFFTLHSRTNPGAGKHVRRHSTVPCTDSAVNLDPVSIILMSTLMTVAMC
VVMFAAQRSFPRNVEGLREWGIGMAGLVLASGLFGLRGIVIPEVLLPLANSMFLWGVGLL
MVGTQRFYGVRPSWHLFHGAWLLGLLVMLCWLYLWPDFAMRVAMFSFLMLALNLTQFIVI
VRHGERHATTCFFGLLMLVQALAMLHRGVNALLGGAGSDMMHGGPHYNLYLALLAFMTLL
LPVGFITVATRRLQTLLEQRSNRDPLTALLNRRGFADFHARHSARQPLAVMSIDLDFFKA
INDRHGHAMGDRVLVDVASVIRGVLRDSDAVARFGGEEFVVLLPESQQARAELLAQRIQA
ALRQPRPDASLPHYTLSIGIACQAAEDESLDSMLQRSDRALYRAKQLGRNRVEVATPALL
SPQAPQHICLN
>A0A1T5HYD3|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MRINNTNYNFITLLKSFILLFFLFSSFYVIYNIYHIEKFNQRYITKIQTVYSYVRRFGSY
YNNASEEHKLKADYQIDNVSIIINTPGKVKKLSKGISLLRSELDKLTNNVSAISVFENST
NNAHFCPIKPKHSNKLNNDAENNPMHQIVVREGLINTYQSFYGCNLKLTESYTDDCSDTQ
IRTIYYPIYNNKRLDALLAIDIKSKDFTDSLQQYNKKYLTVININHSNNFYTKQELLPCS
KIHPMNMGFNLFSIFRVTFLPALLLSIIYGYFKIHLIKKRHNIQRDLMTHFYRRDFYEKK
WLKQRKFNLLIIDIDHFKKINDNYGHEIGDEVIRHIAKRINNYIDPTDTAVRWGGEEFII
NFQNISNKQLHIKAKDLCSLIDSKPILSLNVTVSIGGISTTNSHFNDAYKLADKALYHSK
NNGRNQYTIV
>A0A554WJU2|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MGSPASTPQEIAREAVRLLAARRLPPTPENFQAAYHEVAGTRPLQPFPLAQLRQIAQALP
ERTPAQVRFKALFNKAVARHSWDDLEKLLVQHLGTAPAATAPDGGASPTPAAAVPACAAA
QPASPSDAAGEAPIAPEIAEQAARVVDVALPLVAADDARLREMGEELVRYLRLPQHHAAT
LKRMLADYAWRLSFGVDEQLGVRQALLGLLKQVFEHIDAISPDNPWLRQQMQALVQAAEP
PLSQRRLEDLQARLKDVIVKQAEAREQTLRAQELMRQTLATFLERLAQTTVSTGQYHAKF
EACAQALERAESLADMAPVVQEAIQTARAFAADTQRVVDELTDLRDRADRAEAEVQRLRR
ELDQMAELVTHDLLTGVLNRKGLQSALDRETRRAERTGTRVCIALLDVDDFKRLNDTLGH
LAGDAALKHLADVARRSLRPQDTIGRYGGEEFIIVLPDTTPEEACGVVQRLQRDLSAHLF
LQGEQQVLITFSAGVTELRRDEPVEAAIARADAAMYKAKRAGKNRVMQG
>Q189V1|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MREESNSLSLDHIEIFFELLSQSTEDYIFFWDINRNKFKISSAIFDEFNLSKEIESDLVN
CWSKIVYPDDVQIWKDDIQELLHGKKGEHNLEYRLINKYKEIVWISCRGKVYVSDDPKTI
FLVGRIKNIGEKNKFDSITGTWNREQFEHRMNYLIKEKIYKNGAMFIMDIDNFKNINEKY
GHSYGDKVLRAIATEVLEYLPKDVRLYRLDGDEFAFFYPMCTKETIEKIYEKIQMYTNTQ
HEIESNKYYCTVTAGVAMYPEDGDNYLDLFKHADIALDIAKISGKNRIKFFSQELYENKL
KVISMQQKLRECVENNFNDFELFFQPQVNAVTKEVIGAEVLLRWHSSTYGEVSPVEFIPI
LEQSNLIIPVGKWIIKEAVKQCKEWHKINPDFKISVNVSYIQLKEDFFRDFIVECLVEYQ
LRPEFLILELTENCWIPDINLLNDKFISLKGIGVYIAIDDFGTGYSSLNYLKELSVNIIK
IERSFVKNITYNSYEYTFLEYIIKLAHIINLKVCVEGIESYEEYDIVKSLGVDIIQGFLF
GRPVSASEFYKFQLSK
>A0A1T5I5A9|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MKLRLKSSLALLMLIIAVVPAAIVGGLLLKQQSDVEANYRIGMLDRLSNTIEQEFDYRFS
LLSTSLDVLSRDRLFVQAIDNFFLAGHVSSSLGTLVKNTPLIQAAYLVDDQWSEVESYNG
IHGLSSFLKLKDLLTYRLSTNNGKGRQWVFYYNDEDLMPKKFNPTRRGIIIGVPIFQSMT
NGLKRIPLGYLIIVVPIENIVKVLRPYLKDGERVVFQNHRSDLMDHDGDMSEIVIAQGKI
DQNTPTIHKTINIKLENKYISEPIQYTMKVYMDKYLGENPYINSLKYISLFGVIIILLSL
FSAGLTYRWIARPLGGLMDVVRAYSRGEYKSSNKQLRFAEFFMVERLIRNMAKTIRAQMA
DLAATNKELNAAYLEKEQANLQLVNFNDELERKVEEKTLALSRSLLREENRRSMLQSLLS
FSHELQSGDIIETVMTQVVALYPMAGWAMKSYTGNKGIWACENIDQSRLENQDIQPESHY
SDYYCVPNNGKYLHCFKVKNSQNDIVGMIVMQYIQLEHDDFEVISLFIRQLATELEGRLL
NEELARIAITDSLTGLANRKAFDKDLEEHIQLINRYPDRHFGLFMLDVNGLKRANDQHGH
SMGDALLIETSKLLVETCRLTDKVYRLGGDEFAIILEAGDCDSCDILWRRLETVRDQINY
ASLPNGKQVEIHFAVGYASTDQYSAEQVCLVADKAMYKDKRHFYEQTGIGR
>A0A7W5IKN3|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. WP4_3_2|TrEMBL
MTEKPNDSSAPDAALTEGGPDEASLEGALEAVRTALEQPLPGAADVPMMVLLVDDQAIVA
EAVRRALSSEREIDFHYCSHPEQAVGMAEQVRPTVILQDLVMPGTDGLTLVRAYRANDAT
RDVPIIVLSTKEEPAIKSAAFAAGANDYLVKLPDSIELIARVKYHSRSYVNMLQRDEAYR
ALRRSQQELLRANLELRRLTHSDGLTGLSNRRYLDEFLGAEWRRAQRENTEVSLLMIDVD
YFKPYNDTYGHVAGDNVLRSVATTIRREVSQPRDLVARFGGEEFAVVMPGAGSAFARLMA
EKMRRDVAALQLPHVGSKVSEHLTISVGVATLTPSAGLAETALIEEADAALYRAKREGRN
RVAFSNEVTARS
>A0A543Q400|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MSRDAPDPPPKNGPWRRVWARLGWGGGLPAGASAAAHTRLEQYLAFSKAVGQVMEHTDQE
HILLESLCTLAVECTPVTLAWVCRVELDNSLQSLAEAGDTAYLDSFAERRSGLPADHGPL
FRVWQEQQPLFNEPFSEGPLRKAWQQNTRPYQLRSMAVLPIHRDHQPWALLVLYDRDQRG
FPQDCQVVLEGIARRVSEALEDWIGILRERVAREHQLLLGTALQAAEEGVVLTDADRRIL
YVNASFSRMTGYTLAEISRFGLHHLQGPRTDPRTLTEIDEALCGQGFFNGRLLNYRRDGQ
TFWNHLSIIPIYQRTGAISHYVGIQRDVTAEWLAREQLEYEACHDRLTGLGNRRALMDQV
AVTLPRVQRGHGALAICMIDLDHFKPINDLYGHEAGDHVLRVVGRRLHAALRRSDYVARL
GGDEFVLLIEGFNNFEELEMILVKIEVVINEPIHLKSGVVVGVRLSMGVCLSNSVYTDDF
ETLLRYADQALYRAKANKRQRTRYWELCVMEENADETTRKPSSADPVSVNRSDADEN
>A0A2X2PVT8|diguanylate cyclase|EC 2.7.7.65|Burkholderia cepacia|TrEMBL
MQIAPKPANEAARLDTLHSLSILDTPPEERFDRLTRLARRLFDVPIALVSLVDDDRQWFK
SHAGLDVTQTSRDVSFCSHALLADNTMVIQDALNDDRFHDNPLVTGAPGIRFYAGRPLVA
PNGAPIGTLCLIDTRPRSLEPDELALLGDLAHMTEREIAALHFATTDELTQLTNRRGFEI
LARHVLSLCDRLGRHAVLLFFDLNDFKAINDRFGHAEGDRALKTFADTLTGALRDSDVIA
RLGGDEFVVLLSATDPADVAEPVERVTQALALRNTADARGYDIRFSVGYVDYDPAHHRDV
AGLLASADQRMYEHKQRGKTAGA
>A0A8G0UXA6|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MLKHLATVSKAAVRPQDMVARVSDEEFCVLLPDTTPEDAAEIAGRLRLAIAACVHAGRDT
VAIWLAGAGDPLYGIDRRRGAGDGRMRQPRCAGRPGGPQTLRGQGARQEPCGSARVI
>A0A8J7V9Z7|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
QDIIKRLRDGQLTLASLKHQMLISDAEIIDSVAILVRSGLVELYKTTAKQKQDALQEDSK
NLAQAAAFAYAYQTSSKQLELIDSANSQLQAMISKNSPTAFVFIRGVLSHSAPRLLAKIK
QLLRHEDAVHKVDDDQLLVVMKATNSTEAARFVNRLRTQGGSDLLTVVSTNKDQEALSLY
HTAVVSAPEDGDSVNVLFDRAHLAFNVNKRVGVKSGITAKSHK
>A0A839BYE5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00318|TrEMBL
MDKDFTSAPRPTFKRTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSVAANETLAALGKQGQFAVAEVLNVHKKRFAYWSWNPADNNDTLGALVS
RWLFPEPISQPVFHNGSTIGEIRLTARDSLISHFIWMSFAVLTGCILFATVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVARRMVEFGDKRHQSYRLGGDEFAMVLYGVHSEPEVQHLCAALSQQFIRPFEL
HNGQKASMSLSIGFALAWENGSVEALLEKADRNMYLVKNQRTKTIN
>A0A1V5JQK1|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin510|TrEMBL
MTHGQIDYNALFMRLKENEELDRKFFEIQTEVLSTLNFEDLFSKLLKLIKLKFGIPYVWL
TLIEGSKPAQLMRQLRLSEPVSFVTREDFLLAVGSSGSPLLVNRGLERLGNLQPAGLYYD
FRSLAVVPLSLDGEIIGSFNQADPSIQRFRPGIDTCYLEQLALVVSICLSNVVAHEELRA
MAFKDPLTGLLNRRAMERVLKRELARAQRYASPLSVVFVDLDEFKQVNDRFGHDRGDELL
CYAAERLLALTRESDIVARFAGDEFVLILPGVAAAEAEALMQRIKAYFLKYPLKKPDQSL
AVKLSFGVAQATQDEDHNGLLKRADDELYRAKKAGKAAR
>A0A3N6E7F6|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI96-15|TrEMBL
METESEPYVRLATLRQLHQVIADLNSARSLADTLQTVADGVVTGLGYELSAVNLVQADGD
LVVAAVAGNSSAEALLTGQVGPRHSWDHRLSIAEHWGDLRFISHTEAWQLDEDGVPGWYT
PAPVPRYEDEWHPGDRLFAPLHVTGSDELLGVISVDRPRNGRLPGPWGQEAFQMYAFQAA
IAISNARLRANMQRALVRLEREQQALRASEESFRQAFEFAPSGMAIAEMGGDQHGRILRA
NDALCRLLGRRAGTLRRYTFSDLAHPEDIGTLLRTSAEGGRTEVRLSTSEGAYLWVSLRN
SVVADATDGPRLLLTHVEDITERKRHEMQLAHRASHDALTGLPNSAELRARLSARLCTRP
HAGRPSAVDTLDAAYGGPAPGSFPVADPDAYEADAHDFDLGLGLGGARHAAGPTGAGFGV
APYEHHVHTVAPDEDGDQDGEGAKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLT
SGVRDGDTVARLGGDEFVVLADGLCHADAQDLAVRLRNAIIPPIRVDGRAVRVGASFGIG
WAHCGMSVEEVLQSADQRMYIEKRSRSKQQRRAG
>A0A7Z0KZX4|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. WMus005|TrEMBL
MTIEILSPQNSSPNRWLSALIIGCVVFILTLFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIMIGPALSNIKFALLNLIQAGVGGMLLRVLLDRRAPLNS
LSDWARMVLSVGIVTPVLGGLLALWTLQVRGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRSHFSDLHLAESLLTLLLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFINASFISVLLAVDLVSVVNNNTVLGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPQGKWLQVNRSLCQILGYPDEELKRMNFQQITHPDDLSL
DLQHANRLLEGEIDTYTLEKRYFRKDGEIVWARLTVSLVRDGSQAPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFSLAPHESPSYDLWIHL
LHPADREHVALTVQQAIELRSAFHMEYRVVNAEGQRWVRTQANRLLSKEGRIERMLGICQ
DITPLRKLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGLSQEQAAGQ
SLSELLHITQGRNGPEVENLLLCQLPPEKITPSLADDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHHLRSSDFLARLGGDEFALLMPDCDV
DQAHDVVQRIVAAVNDYRFQWLGRLYHVGASAGVTQISPENCQSSDVLSQADIACYNAKR
SGRGRLMIYEQHRLPLPGTHQDMDAAMIDALQIELPAWAVAPPNTPQSAFIWLLDVQLLT
ADGLLLDETLLRNNLPDETLLRRRLDNNILEAFFRHDVEKLNQKGIPVILPLNAELLNDA
AFVQQLCQRFIAAGLSESHCGFAFPAASVLSKGDQCYAALLQLRQCGCRIVLHNFGRNLD
AFNLLSDEMVDYLLLAPELVANVHNNLMDEMLLTIIQGQATQRNISVLAGPVTVPALLST
LENLNVDGVWGSAVAERQPLRSLAEDRIFAIR
>A0A521N8Q0|diguanylate cyclase|EC 2.7.7.65|Sinobacteraceae bacterium|TrEMBL
MASRNSGAARPSRGMPRRPVAARLSNGLLAKGMSGGVTEFRLPYCKPRASLVRPRSGRLM
QVIARWPGSWEPRKQVPTGRRLMPALPQVQLQAILGQLDQALYNHEQWTKGLVRALVARL
PADVTDLRPDAHQRCRFGQWIESGEAEPLRQHPTFVALAQSHEQMHRQAAGMLRRGEEGL
PVSAEEFDQFGNSLDRVRLEIQSLRRELSETLQNRDVLTGARNRVSLLSDLREQHALVRR
GVQSCGLVMFDLDHFKKVNDQYGHLAGDAVLVATVSCVQARLRPYDRIYRYGGEEFLITL
PGSDLPTAIATTDRLRVAVAEQADSAVTATRPRQVTASFGVTLLDGSATVEECIDRADRA
MYAAKSGGRNRVECWSAEPASPEQGAKPA
>A0A380T4X8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MTQTSDTPPLKAPLADFREEQLQTLLELISDGIWDWNANTGYVYRNPGWYRMLGYPSHSL
DNTVLTWEGVIHPEDYPRVMAHFEDYLTDRAGRYRIQYRCRCRDGSYLWIEDSGHIIARN
EDGSVARMLGAHRNIDDARRLVDRLEEKNLSLEAQIAERTRELSWVNQQLQRQLDENRDL
AERDALTLVANRYRLEKVLQQECERARRFRQPLALIIMDIDDFKPINDQYGHAQGDQALI
ASVERIKVCLRSDDLLARWGGDEFVAVLPGTQRQEALQLARQIRQALEQAPPVGERLLTM
SYGVVEWLEGEGQAQLLCRADQALYRAKAAGKDEIGE
>A0A1C5P3Y6|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDGLPSGYRWLNIAANYLGFGLAPAVSICLVYVLDRKTVFRRKIRTAMCCEIGYLIFLFC
SIPYGMVFSVNADNIYSRGPHFYIYVIMYFGAILYLSVSTIVTAREYQNRSRLLIYPLIL
FVMAETIIQVALPELRVTWLCVTLLSVLYFIYCNEMWNQLDALTGLLNQNSYLKRTSGRR
CNGGVLVVFDVDDFKQINDHYGHVQGDVCLAEIAECIKKVYANDGYCYRIGGDEFCVLLK
NSAKEGKCRQEFLWCMEEKRRKITFLPTVSYGSASFSGEDIVEVKERADRDMYQYKNARK
KRSNME
>A0A6N2SFS7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MQKRKFWEIFFQWVFPCALLVVALVLSIYEFNNKMNSAIRTVVDDQAEQIGYYYSAGVDD
KLGALGDITSAMANIMASRPDRSDAFVYEKLDTIVKASNAYMSAYCAVNGNGMLSDRREF
DMSELNYYGSISGTSAHYIYAGTDGINGQTAFIYVCPIAISGNVTGYLLSYMNPDNMKEF
FDNSVYGDKAFFSLVNRNGTIMACYGATDGTAILQNDFWNSLKDISESLGSWTLFERQQQ
KGNNGILHVKEDGVGKIICHFPIRGTEWNLVVGINESYLSGIQQSFRGPIVNLIVKISIS
IAVALIIITAINILVRIKASEHSKVLEDKADTDLLTDLNNKMATERKIREYMEKYPDKQG
VLFVLDVDNFKKINDTMGHAFGDEVLRSLAVRLQSMFRATDIVGRTGGDEFMVFLKDIRE
ISMIEREGKKIEQFFHQFEVGEYVKYSVTASVGAAVFPGDGKSFEELYKAADNALYVSKR
HGKNQLSFYKKPGNETK
>A0A1C6GWU1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MENNELQYNLRKFEEDENHIEYFISIFPEYIKSNPEKAKEILDLVMEIALNKEYELAYGW
CLMYIGWYCFTISDYTNACKYRLDANEIFIKNNCVKGLIFSYNGLLADYTRLGNLELAIE
SGLSGIDLAEKENDEKALIHLMINTAIAYMDYRKYDEAKRLLNKINEVYRQIQGSELIVY
YITLAEVEVISGDINKGYECCEVAIELIKELGCWIYECEILSIRAEANSKLGKNKEAEID
FEVAIKSAKSFKNIIYIVKTLRRWAKHYNRIGELDKAEKKLIEAFNEVNSLNSLLDKSEI
CYELNELYAQLKRYEEAYKFLKEHLEIEKEIFNNKSSSWLARLHNKEITREAKIYRELYQ
EIDLLSGIGKKFTSDLKIERNLEVIYEEVKELMEADVFGIASYSKEEKILKYDLFIVNGK
RKNCGISALEEENFGTWCYKNKENIVINDMENEYRKYVPSRNKGIEDDNCNVKNIKSAIF
CPIVVENEVLGILTVQSYKKNSYNKNTVKKLEILASYIAIALENAKLFKNIEYSATHDWL
TDVYNRKEILKRGQTIIQNNKGCSVMIMDIDYFKSINDNYGHATGDYVLKTISDLMKKDI
KGNGYIGRYGGEEFLIVVNSSNKEYVSVLANNIRKNIENYNFIVDSKKINVTVSIGVYNY
LKDDKYFNKHIKLADEALYLAKLFGRNRVVNY
>A0A1C6HKK5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDVTKAVATMQGGSLAEFLRENPDQGILLGIIIVLIFAVAFLAWCACVGKWQKRAAALEH
ERCIQLCELSNECFFQYDIKKDRICFSGYGAQKLGYEPRIDHASSLLEQAEWDKTPETGM
IRYLTEVKEDSQELRARLLRGETRWYQITKKLVVDEKNRPVYVVGKITDIQQLMEEKERW
ADKARKDGLTGLYHPTASRDFIQNYLDGRGNKGAFLIIDIDHFKGVNDRLGHLAGDQVLM
GITQILQQIFRKDDIIGRLGGDEFLVFLTGVRDRKIVEKKCRLLCKKVKEYTEREHNEKI
SVSIGAACVSSGMHYDRVYKAADNALYVVKERGRDGYEIVGL
>A0A6N2TJ36|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRKWKAWLFALAVLIGIGTIGTVSVTAEAQNLNQGKRVLFISSYSYGWDTVQTQIEGIKA
GVDENTTIDYEFMDTKRFRTDEWLNMFHDMLKYHLENTDPYDVVIVGDDAALQFAMEYRE
ELFPEIPVVFEGVNDEEYAMKAAENPLVTGIIEKLSVEKNIDMALKVNPTADKVVAILDD
SVTADAERKNFYNSAENYPELEFSEINAAELETARLQQAISKVDDKTILIYIVMSKDGSG
KQYTSDQAVRMVVNYSKVPVYRMVEAGIGDGLLGGNVVSMYKSGEIAAQMAMDIANGTDS
AEINVVKDSPNIYCVDEDVMRKFGLEASQFPKDTEFVNHRESFFARNREALIPALILITA
LNVIICWVCFDNYRRRKLLQELEQARAIMEAASQHDFLTGLPNRSKFMKDLEQMIDAKVP
CTVMMLDIDNFKKINDTYGHTAGDEALQQVANRLKEMQSQILTSYRFAGDEFILILRSSQ
NMLVEKTAYQCRQVFTKDVVLCGTKRKIGGSIGIASYPKDTDNLEQLIVCADDAMYQVKK
NGKNDFAFYKKPEEEKTDNTQ
>A0A1C6C117|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTETIFETLLKEMEEQQKLHHLPIVEKKAKQLLKLAEKEQNHYYESIAWYFISLLSFYNE
DKQKAMKACGQGLKLCESADNVRYEIRLMNLAGILYADSSNELTALHHFINAYFLSKEHP
EYGFMQLILKNMGTLFFSIGMYQEALQYYTEAFDYMLLDKFEKGDLQIVISHIMFTLARM
NEQEEVRIWKKKYDELDNELAKIPEEYVLSELYLDVCAHTTSKVPEKMEQVLKNLYQEED
YSHIKNCMFFMLEMSLHMKNDSLFIKLYQTAKKLFKDMKNPYFEEELSQIYIQYLKEFHK
DNLKDEIYHHYEIYQKAQSFNLENRKISMKVKMDLENTLYKQRKIIENNQKLMQYTELDD
FTGVLKKTAFRKQTIEKLQRRNKDQKAFFLMMDIDNFKHINDSYGHMIGDRVIKEIVAII
KNNVDQNTLIGRVGGDEFAIYADHIYELYKIENCVEKIKNDVQDIKIRNVKKRISISIGI
CEASDDDSYDIIYKKADHALYEAKLSGRNQYVVYEEDNVQEESLLPMHSNEFSKLSISAV
LPKVFMILNTEKKSNTILDRAICYLGRTLHIEDLFLLYFIDRKKEQGYLKVFNLNDKSIR
SQAIYHIEEGYFNEFDETGLFQNHNLNHCDFPYETKYKENHIMSTIQKKIEYDGHFYGIV
GMNKKSRQVWNIKDVLLIENMACAFSTYFESWRKQD
>A0A0H3H563|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca (strain ATCC 8724 / DSM 4798 / JCM 20051 / NBRC 3318 / NRRL B-199 / KCTC 1686 / BUCSAV 143 / CCM 1901)|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A6S7F045|diguanylate cyclase|EC 2.7.7.65|Achromobacter insolitus|TrEMBL
MLDPILAELSTALPQAKSVEQLTRPLLDMLGAVTGLESTYLTSIDLKADLQHIRYARNAG
QLQIPEGLSVPWDDTLCKRALDEGRMCTSDVSSCWPDSDAARQLGIQTYLSAPVRSDDGV
LFGTLCAASAGRHQIEPQAESVLKLFSSVIAGFLEREMLMEQLHAANVQLMSYALTDALT
GLPNRRAIYEALDRLQARAIREGGSVLVGVIDLDGFKGINDVYGHQHGDLFLQEVSRRIA
AALRGSDMLGRIGGDEFVLIGPGPALALGDGPHGGHGAAAQRGDAEEAARSLEERATAAT
VGRYQLGEHVVPYEGASVGVVALDPNGLDAEAAVRLADARMYEVKRARKTARVIH
>A0A6I2JWK7|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT702|TrEMBL
MPNSPQLSRWKSPFIPVHLCFLAVFLFSAFLTVHEAFELKNNYEQRQRAQLSDVQKNLDS
QFQESLDELLYYQQMLNYALTHPLDSDHARETVARFQQLRQQNPWQLQLSSPRSMPINGV
GDSWLTRDPLLSRDDTHIDHELRAALEFSFILQFGDTKQDFHSRFWYISRAGFYISSRPP
QNAQELEESYATMIQRPYFRDQDPHNPLHARLRWTEGYQGLFDEGLMMTVSTPIISEGYW
YGVLSMDFTQSRIHALLASARNSSLQGKMVLLDRSLHEITRLTAPNDQPLTAEQKALLEQ
QILQSPAGVSRLGTQFITWSKLRNVDAYIVNVQSLKQGFSQELGRVALFMVGMWLVFVLL
LVAAHQVIFRLVRRLNDMSAKLVWRANYDGLTRLLNRSAFFEQFDALAARGQQQQTPLAV
IQLDIDHFKKVNDTWGHQAGDQAIIRVASVISHTLRKYDVAGRVGGEEFCIVLPETTLAE
AQAVAERIRVRLEAKTILVNASTTFGITLSAGVSGSEEQGDYAAESLQASADSRLYLAKT
GGRNRVCAAD
>A0A446CC07|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MDTALKFSLPKWRLTRWLTHSGHDTPADIRAALIASLFGTLPIFAGGVINTLMISGVVAW
RRPEPLYLSWLAMEVILAAVRVTVLRSALRAAPKGGNTHTDIYILLALLWAFSVGYGVFV
TFINGDWLAATLAGVSCGAMAGGICFRNYGAPRLVGAMIFLSLGPMCLGAAFTGEYVTAI
VFIQIPFYLVSMSIASHRLNRILVSTMLAERDSERRASEDALTGLANRAGLQAALERVCA
SARSHDSSAALLYMDMDDFKLINDTYGHAAGDQVLMTIAQRMRAMLRVDDVAARIGGDEF
IVLVTGIDATSALRLGEHLLHDVSQPIGLADGTRVSVGLSIGISIVSGANRSPQGALDSA
DAALYRAKARGGRCCAVAGGDEAGDAENGILPGGARAVA
>A0A8H8ZG45|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MKTVRESTTLYNFLGSHNSYWRLTESSDVLRFSTTETTEPERMLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQGFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A8H9DFU9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8H8ZC38|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A5P9PEJ8|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. YIM 10|TrEMBL
MVAVEVVAAAFVVGSVFLFRVTSSDLVLCAVLAACGLLAGEVSRQVERRRRYFADTPHVN
FSSVWTLGAALVLPPVLAAAVAVVLYAHLWWRSDPSGGYVSRFAFNVSNVIVSCSVTAWV
ARELGALPLDTILTLREVVAIGLLIAVYFMVNSAVAAATIALVRTDRSARQLLGSFNENI
LEVATLCMGMLAALLLAWHPALVTLLFVPVYALHRTVLLRQFEHAATIDAKTGLLNATAW
TTLAQAALDRAQRHQQPVGILMIDLDHFRRVNNSCGHQAGDAALAAVALAIRTAVRGGGD
RLCGRFGGEEFVVTLPGASTAEVERIADAIRTAINTVNVGDIDALDGWTGTLSASIGGAI
YPTAGQTLDEVLLAADLALFAAKDAGRNRVCVKTS
>A0A7Z7MVJ3|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MIPTLRRALPVVIVLAYLLIGLLVLLSFRLNLPATPGAQVGTLLWTHLLAYFAIAGLTHL
LLRQFAQGIPRSAQTPDRQQQTAVDTTEHLRAERNRRLAMAVFESTAEAIMITDGGNRIV
MVNPAFSRITGYSPEEVVGQSPNILSSGRHDGKFYEDMWRSILQTGSWSGEIWNRRKDGS
PYIEWLTITALRSSEEKPHLSDLEGCYVATFTDITLRKETEDQLRFKANHDMLTGLPNRS
LFEDHLQLAISHAKRYHRSFALLYIDLDYFKNVNDTMGHAAGDALLGEAGKRMALCVRES
DTLSRLGGDEFAALLSEINSIEEIEDIARRVVSTLDQPFQLEQGIARISGSVGIAIYPQH
GTRADELKENADLALYTVKKTTRNAYLIYAPEMKEDKEIAG
>A0A5F1DSP3|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4930|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0B7D8K4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPMECVMLVPRKPANEEARIQALHGLNLLDSAPEERFDRLTRLAKRLFNVPIALVTLVDK
DRQWFKSCVGLDATETSRDISFCGHAILKDDLLLVRDAREDERFHDNPLVTGEPNIRFYA
GYPLTVPTGNKLGTLCLIDTKPRDLDEEERALLRDLAEMAEQELTAVQMASMDELTLLSN
RRGFKQLAQHALDACARLHRPATLLFFDLNDFKQINDLYGHAEGDSALKTFADVLRIAFR
ESDVVGRLGGDEFVALLTGSSHIETTAVMARLKEILEERNATLHRGYAIRFSVGQIEYDA
QRHDNVDRLLADADAAMYAHKQALKRIQ
>A0A3S4MMC8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRHPLALLAVIFLLLASAVSRAAPEFPAPPASGAWLNGSLDLLEDPDGNLAVEDLEQAEQ
AGRFVAAAGRTSVGLSRSAWWLRLDLPRREAVSGGWWLEVASASLHDLRLYLPDERGGFR
EHRSGEAVPFAEGRDHAYRHPLFRIPPGDGPLRVYLRSYDPGGNTFPLRLWSHDELLEYR
SQGNLLFGMAYGLILALLLYNLFLFTSLRDRAYFWYVLTAASALVLTLSISGHGFEYFWP
ERAVPWWLDRLALLAIWGICVIRFSQNLLQSRQHARWAHHLLNACCLLFLACLAFNAAGW
RWQAAGVLALTLLANLPIAIGLAVQRWRQGSATARLYLVGFGLVLGSVSLGVMRATALVQ
PTSANAMVFPLALTLEALLFSLALASRIQDLKQERALALDQADQEKNARLALLHSAQRDL
ARAVEVRTNELSEANRQLQMREAQLQYAAHHDPLTGLGNRRHLMEFAESALDDARRHGNS
MALLLIDLDHFKPINDTHGHDAGDFVLQNVAQRLRHCVRTEDCVARLGGDEFAVLVGGSN
AEQHARDIAERLLRELAKPVEFAKQWLVITPSIGVALFPGDALQFGKLYKAADQALYRVK
GAGRAGYAMAADDERETAPALPWPTALAPERIS
>A0A448DXN1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLVPGKPANEAARVQALHGLNLLDSAPEERFDRLTRLAKRLFNVPIALVTLVDKDRQWFK
SCVGLDATETSRDVSFCGHAILNDDLLLVRDAREDVRFHDNPLVTGAPNIRFYAGYPLTV
PHGNKMGTLCLIDTKPRELDDEERALLRDLAQMAEQELTAVQMASMDELTLLSNRRGFKQ
LAQHALDACTRLGRPATLLFFDLNDFKQINDLYGHAEGDSALKTFADVLRIAFRESDVVG
RLGGDEFVALLTGSSHVETTAIVARLKEILEERNATLHRGYAIRFSVGQIEYNAKRHESV
DSLLADADGAMYAHKQALKGS
>A0A5E7DKE0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRILGLALGLLCVGAAMYPLDPPPWVWVLMLLNGILWPHVAYQ
WARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQVLGGGIGWLIFRPLFIPQTTPLQMYACLPLLSLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQHQGGAVALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKQNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQNPA
LRVSLSIGLAAINPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRHELLDPV
>A0A8B4HZ20|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVHEKPYLPDAPTAEPPRPAAAATLLALMHAQGEVERLSEREQLLSSLLVSVNAVLWAID
WQTRRVLYVSPAYERVFGRSAGLLLADYREWRNSIHPEDLDYAEHSLARVLEHGAVEDRE
YRIITADGHIRWLSDKCYINQQVEPGAPTIVVGMAEDITEKKQMALELHRLATTDVLTQS
SNRRHFFECANQAFDNACAQGAPLAFLLLDIDDFKDVNDSYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCAPEMAMQVAERLGKEIQALSFSCEGRAFTVTVSQGLAN
LCEDDSTLDSLFARADTAMYEAKRQGKNRVVAG
>A0A5E7SPR3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLLTPGSRPTLHSVIGRGNLLVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKPATTEALALIAANEEVADAQVFDQQGQLLARWQRPETGWVSDLELHIAK
AFLEEPMSMPITHQGREVGSIRLTGHGANLMRFLLSGLVGILVCTAISAWVALFLARRQL
RGIIKPLRNLATVAHAARSDRAFDKRVPPADITELDDFGNDFNALLDELEAWHSHLQSEN
ESLAHQASHDSLTGLPNRAFFEGRLMRALRSANKLGERVAVLFLDSDRFKEINDSFGHAA
GDAVLVAVANRVRAQLREGDLVARLGGDEFAVLLTPLHKTEDAERIADKILASMDIPIPL
PGSTQVLTSLSIGVAVYPDHGATPGALLNAADGAMYQAKRLSRGAQYTAGSEHPAADVQN
RS
>A0A3S4QZN3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVNNNQKDSCFPQWPEAAQTLMALMHAQGEVARLSEREQLFSSLLVSVNAVLWAFNWETR
QVLYVSPAYERIFGRSAALVLADYNQWRDSIYPDDLDYAERSLAEVLHKGAVEDREYRII
AADGQVRWLSDKCFINRQDEPGQPVIIVGIAEDITDKKHMEAELQRLATTDVLTQSSNRR
HFFECANREFQQARLQGSPMAFLLLDIDDFKVINDTYGHQEGDNVLQRIAECGRGSLRRG
DVFGRIGGEEFAAVFPGCAPDMAMQVAERLQQEIQRLRFNHDGQTFGITVSQGLTSLTED
DESLDSLFARADMAMYEAKRQGKNRIISA
>A0A1V4WR93|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaB.Bin047|TrEMBL
MVEDGSRRGRALLVRSLAAITVVVSLFIGVFLVVTQYYTNALFEGVEREYRQGLVNTVSV
ARNIVEPILAKVRSGEMSREEALRQIRPIVRAMTYEDRNGKNYVFMSSYSGIMLVQPYEP
DKELTNQWDLRDVRGTYIIRELVRAAKERPEGSFVRYYYHTLPAAHDVQEKLAYVVGLPE
IGSYMGTGIYMSSVLEGQRRIVTRIRYVSIWLLIMLLVPACVAALVILNRNRRLIEERGS
RSRAEENLKESEAKYRSIFENSVMGIFQSSPEGRVLGGNPAFSRILGYATPEEMVEALTD
VTRQLYVMPGDRAKFQGALARQGHVEGFETEFYRKDGTKVWTSVNARAVRDADGNIAYYE
GTVENITERKRSEEALRTSRLQLSQAMDLASIVYWEVDLPEEIFIFNDPFYAFCGTTVER
EGGYRMTREEFAARFLPPEERPLFHRMVEKNRAMEAAATLPADFEHRIIRRDGEVRNALA
RTRIVRGDTGEVLKIYGAVQDITERKLAERALIESEEKYRNVVENSLIGFYIIKDGLFRY
VNRQFCRIVGYSYDEIVDRLGPLDITYPGDREVVAENIRKRLAGETERIEYDFRTVRKDG
KVVNLRVIGTTTIYQGERVPSGSIIDVTREKTLEDQLLHSQKMEAVGTLAGGIAHDFNNI
LTALVGYADLLRMSTSDEALLAYVDQILSASQKATDLVRGLLAFSRQQAIILAPRWHKQH
REEDGKAPEKACHRGYRGKDLSSPRRDHHHRRYHPDRPDTLQPRHQREGRHAPRGGPHNR
DTGRGAHRRVPSSPRVRRTGEICPSFRFRHRCRNGQEDTGEGL
>A0A109KRE2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKQKRTLGTPRLLGIVWPFIAVVLFQALLGCVSLYVLSAVRGYVAGESLWSKGQKDAIYY
LTLYADNRNDATYLKYQQAIAVPQGGHELRIALDRPNPDMEAARLGILKGGNHPDDVSSL
IWLYLNFRHFSYLEKAIELWTVGDGYLVQLDELAQEMHGAITSGYVSDDDVHSWKARITA
INEGVTPAAKAVSDALGEGSRMILRLLLITNLATALGLIVLALLRTHKLLAQRHAFADAL
QAEKERAQITLESIGDGVITTDVDGAIAYMNPAAEALTHWRSEQAQGLPLAALFKLLDEN
AEPDGFTLIEHIVKGQFSGGSEHSKLIQRLDGSTVSVTLVGAPIRSAGKISGAVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEFRLEQVLQQVARQQNGRHALMFLDLDQFKLV
NDTCGHAAGDELLRHICALLQSDLREGDTLARLGGDEFGILLENCPASVAEKIAESLRHT
VQSLHFVWKGRPFMTTVSIGLVHISQTPTTLETSLRAADMACYMAKEKGRNRVQVYHVDD
SELSLRFGEMAWVQRLHIALEEDRFCLYAQEIAPLGTTDAGNGHIEILLRLHDEAGRIIL
PNSFIPAAERYGLMTSLDRWVVENVFKIIARCMHERPGRPMAMCAINLSGITIGDDDFLG
FLRQKFDTYNIPPEMICFEITETSAIANLGSAIRFINELKALGCHFSLDDFCAGMSSFAY
LKHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALLEI
GVDYAQGYLIERPQLFTFDSLQCRPERPQPLLFKAPGTFR
>A0A5E7CKR7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MCTDLTSAYAFAEQLRLKIQSLRIKARGTDKVLDTITASFGVALAKTGDNLESLLTRADD
ALYRAKRNGRNRVN
>A0A448DXI6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPLDPPTMLTITIALAAAAALYLAIEWRIIREPSLLFWSAGFATITVGSTLALLRSGGFL
LIGIWFANGLLITAHFFFLLGVARFTQIRLSPAWYLIFVTWLLMLWLPDGPLWSKAMLVA
NSLLVALSTLKASSLLRPHGRSLSVGAVQLRYVLLGHGIFYVAKALTVVIPGTLIDLAAF
RGEIIQISLVEGAMAIMLIALSMTGTERYRREKQIARLAERDPLTALYNRRALEKRARRL
LADVSAARPGALLLIDIDNFKLVNDHYGHAAGDRLLIALSEMIRSALPPNALTARLGGDE
FVILLNSASSERIVELSNALREQFLVCASQTFPTPAAVTLSIGASLFDQPPASLTALLEQ
GDAALYESKRSGRNRLRLTGLTTSG
>A0A109KLL7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPANLKLRPRMRSLLSPAVAQAEWVGIIAWVGMLLIPPTLKLDLYMLAVTVGLLIVCRVH
ATTANFLLWRVLGVIYMVLLSVGFAYLIHLNEELRIYGLPLAVTLVVGSAILFISVQDYL
VDALLIWLILWPPMQTDIEAGNEVYLLLFCAASVSIGFILSYSYLKNLRSVLLVESEFRA
LAETDYLTSILNRRAFMQSFEKLLAGEQGGYFIMLDIDSFKEKNDLYGHDVGDKILRAMA
LCLKNAKGSHSFGRIGGEEFGVLLQGDDVEVACDYALDLLQAIRSSVPAPHHYTCSAGMA
RFSPGDELSAVLKMADKNLYGAKRNGKDCVHLDGALLKAILS
>A0A240BJ64|diguanylate cyclase|EC 2.7.7.65|Serratia ficaria|TrEMBL
MGTAMSARINAKHGLPVTVQLINLFMLAFLLSLLGILTRPIGSLSLFWPVNTILLGLLLR
KPAYATPLGWLTTYLGMIAADLSAGEGLALAMWLNACNMSLIATGYGIMLMLPQSQRRMG
KPQAILYMFSASLAGAAVASTLSILRNDSLYNNTVAVAWLAWFSEQFSTNLLLLPVILAA
PRLKQLLSLQINWRLRAGMPLLALLLSLVFSVYIGGPGAIAFPIPALLWCAVRYQLFTVT
LLTLLTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAGNRK
LMRRLEHSANHDFLTGVLSRSALTRKAGELLEHKHRSKEAVSLLLIDIDHFKLINDTHGH
VLGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALAAQGVALGEHLRQLVEKADL
LPGGKAPQKITISVGVASLAMNEVKSLEQLMNMADIALYRAKTQGRNRVESFNVVSGNSV
GHIMFR
>A0A120FYP5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRRGKGLSFARRIYTPRIIGLGIGSISVIGALYPLSMPAWVWALLLFNGIAWPHVAYL
ISTHSPFPYQAEQRNLLYDSVLGGFWAAAAQFSPLTAVTILSMMAMNNVAAGGKRLFLRG
LLAQTAGIAVAWGLFGVKFDPSVSLTEVYTCLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRVDSLTGLLNHGSWKDLLNLKFHKCQQQQGQATIALIDIDHFKHINDVHGHTVGDA
VLRQLSQALREHLREEDLAGRYGGDEFCVILPKMPLHAAAQVMEHLRETFSGYRHAQIPD
LRVSLSIGLADFHPSFKDAVMWLDAADRALYTAKNNGRNRVKVSECGVVQSA
>A0A0D0TQM5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKQKRTLGTPRLLGIVWPFIAVVLFQALLGCGSLYVLSAVRGYVAGESLWSKGQKDAIYY
LTLYADSRDDATYLKYQQAIAVPQGGHELRVALDSATPDLAAARLGILKGGNHPDDVPSL
IWLYLNFRHFSYLEKAIELWTVGDGYLEQLDELAREMHRAIVSDQVTDNEVHGWKKRIIA
INEGVTPAAKAFSDALGEGSRMILRLLLITNLATALGLIILALLRTHKLLAQRHAFADAL
QAEKERAQITLESIGDGVITTDVDGAIAYMNPAAEVLTHWKSEQAQGLPLAALFKLLDEN
AEPDGFTLIEHIVKGQLSGGSEHSKLIQRLDGSTVSVTLVGAPIRSAGKISGAVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEFRLEQVLQQVARQQSGRHALMFLDLDQFKLV
NDTCGHAAGDELLRHICALLQSDLREGDTLARLGGDEFGILLENCPPAVAEKIAESLRHT
VQSLHFVWKGRPFMTTVSIGLVHISQTPTTLETSLRAADMACYMAKEKGRNRVQVYHADD
SELSLRFGEMAWVQRLHMALEEDRFCLYAQEISPLGHTEAGNGHIEILLRLHDEAGRIIL
PNSFIPAAERYGLMTSLDRWVVENVFKIIARCMNERPGRPMAMCAINLSGITIGDDDFLG
FLREKFGTYNIPPEMICFEITETSAIANLGSAIRFINELKALGCHFSLDDFCAGMSSFAY
LKHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALLEI
GVDYAQGYLIERPRLFTFDSLQCRPARPQPLLFKAPGTFR
>A0A1C5XDU0|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MPVQYGGKRGWIRSRTIINGKEKNKKIIGVLENYDEQKEKEAEIEHHLKNINKIQKASQR
DFLTGVYNREGLIQNIEKALKEDKNKQGVDAFFILDLDHFKEINDFLGHGTGDQVLQNTA
KILDQCFRKEDIVGRLGGDEFVLLIRRIDRIEAFIGWQRS
>A0A1C5X0S9|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKKIALITNGQARYMTHEWLHGYRRYISDHNSDIDLYIFHCFGNFSQDQSYNVGEYNIFR
LPRLSDFDGILLDLALIPDHELKEEVIIRARRASVPVISFLDKVPDLYFSGIDNYHAICT
LMEHLITEHGCTKLNYVGGIIGNQENQQRFLAYKDTLKKHGIAFEPDRIYELNYEVETGL
KAFTVFQERRLLPEAFVCANDNIAAGVCLAAQDAGYSVPGDFLVTGFDNTTKSINFYPPI
TTVEFSKAHIMYNALGLLADVWNGTAKSSQVFSPTRCIYRESSGCTSLFPADPGKYVSSQ
IMAEVRQGDMLNWMMDLDRFLLDCTSFTELAEHLHTWLSTHGCGNLSLLMNPDIFLLEKI
DALAEIPDDLYLDFGYPKQMTVVYPCSGNEAGELDLSTGKLLPEVSESDIPNVYFFVPVH
FRKREIGYLVLENCDYLLTHQFLFETLNTFRTSIEALYGKLILQKKNRQLSQLYIHDSLT
GLYNRMAYEKLALPVFNQYMKSKKPVGIMFIDADHLKYINDTFGHDMGNLAISSIASVIR
QHCPANSVSMRYGGDEFVCVIPDYDQTQMQKLKQNLLDSLATLSRNSRMAFPIEASIGFV
VADDSVFSLNDYINLADEKMYAEKKERKATRQ
>A0A1V6IP82|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MICSLVILGYILGFSPVPLRVLVVSQLGILACNIILYVMFRTGLNKRFKDPSLTLLQIVI
ATCWLLEVLYYADSVRSAVLMDFLIIFILGLFKFNVREFLFLSFFTVAGYTGVILLLYIN
RPESLNYKVEILNIAILATVLSWFSLVGGYITRLRKKVALSLATVKESEKKYIELSIIDD
LTQLFNSRHFYAQLEKEIERANRYNQPLTLLMLDLDKFKNFNDTYGHLEGDQVLSRIGHV
IKRCLRDSDSAYRYGGEEFVILLPMTKAEAGITTATRIQETLRKTSFSPVSDQEIFMTVS
VGLSQYIPREDMKVFVRRVDKIMYQAKHQGRDRICTG
>A0A1V6IUE2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MAYKRMSLNINGISRKFSKLAYSLSELAENFSLIPNNDPKQALRIKRFFISIFVYLLNMP
LSYLAYTGGLMEFKELVWGWSITTILMIILYIVFRSGLNKRMKDPSLTFAQISVASLVVM
YGLFFVPEAKGILFAVYVLILLFGTFRLDTRQFLKASAFILGTYAVDICLLQIYRPEAIH
LKLEVLYWFALGVVLASVSFIGGNISALRRDLAVSHKQLQASVEKIQAMAIHDDLTGFYN
RRHLMELLESEHNRSVRTGAVFSLAMIDLDKFKNINDKFGHQAGDDVLMTFSNVIRNVLR
KTDFCGRYGGEEFLIVLTQTDLEEARIFAERIRACIEDCLVFDLEPDRQLKVTVSIGLAE
HLKNEGIDRTIFRADEAMYKAKKNGRNRVEYSE
>A0A2C9EE23|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MSDDANRWKEKYLKSIEQQEKLERRWAARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRE
VVRTDDMDAGLAALLPRLEKAVLDSEQRRETRVEQMSSALTALVSQLQSLPLPREVSRPL
KAFAKQLDGRVGQAREIPLLLGELSSLQGKALSQLETPAEPDRPSLLQRLFGSREASETP
APAEEAVATNPPLPAAAAEAHPQAEEAPAPEDGAREHYQTPTQALPEAVSAPAAPATAQP
EAQLEPEPVASDEPEVAAVPAPAPVVAFVPPVLVQEAPAEPVPAIEVEPQATISPVAEPQ
AHVDPGVVAASDSPLAPVAEAALNPDELVPLPTVSPAVLLDSLPLPAVMAEALAAIDPEQ
SEHDVLYALPDSPEPSYSSVAKHIEHTLLGLLDDLSLPERHRPQAEAMRDRLQHGLNWYE
LLPILDDLAVLMLAITDSGQHEFETYLKQLNERLEAFQSNLQAASDGHADSSSAARAMDS
QIREQVDGLQSSVQEAADLDDLKQVLESHLEGLLGTMDHHQKQRDEREREVAARLQSLAE
RVSSMEQEAQGYREHLEEQRQKALIDPLTGLPNRAAWSERLEHEVGQWQQHGNSLLLAML
DLDHFKRINDNYGHLAGDKVLKIIANVLRKRLRGSDFIARFGGEEFVLLLPNTPWPVGVR
IVEALRAAIEACPFHFKGEPVTITVSVGLSAFKAGDRSDLVIKRADQALYRAKDAGRNRV
EAG
>A0A8H9ECV6|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A2C9ERB8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQQSPLIKQPISLAQLRQQLGLQLQTSLEPQRILGLFF
REVQRLVPLDALQYQHTPSDLRLEFGQRGHHSISYSLSHEGEPMGELVFRRNQRFSESEQ
GSLESLLSTLLYPMRNALLYRAATRSALRDPLTDTGNRIAMDQTLQREIEMARRHLLPLS
LLMLDIDHFKRINDNHGHSAGDQVLKAVAAAIKGQLRNVDMVFRFGGEEFLILLSNTGRE
AAAMVGERLRHAAQAQDYRADGQPIELTVSLGCSTLLPGESAESLLRRADSALYVAKREG
RNRLAMAG
>A0A850RXI6|diguanylate cyclase|EC 2.7.7.65|Serratia liquefaciens|TrEMBL
MDISAPNHLITRQGALFTHSLLAAMAVFLLALLCLTLSNESSHFTPLWFPTAAIIAVLFR
HSPRQWGLPLLACGVGIVAASFTLFGFSWFPVKLTLINLLEAVVCTLLLRRMLLQDDPLN
SLASWLKFVVCAVIFTPLFSALLAAWWVPAPGHPFWHPFSTWFISEAIGVLSLTPIGLVY
RRRMLDTLNLYTLLLTLIVALTFSYLALSYLPFPFTFVILPLLWAAIALPRLEAFVICFC
TTLMITVMISIGLLHFHAPTGPFSDIEIYLPILLILIPAHSMAMVMHAFRVEKQHIVESE
TRFRNALEYSAIGMALVSPQGKWLQVNQALCKLLDYTPEALRRLTFQEITHPDDLNADLT
QLHDLLDGHISSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKRTA
AENHRLMERITLANKVGGIGVWEWMMHGEELTWDKRMFELYDLSPDQTPTFSLWRTLLVP
EDRERTDREMATLLKRPGPFVLEFRLLTREGKVRHIRGQGNVILDAQGLPLRMIGTNIDM
TEVRNLTEALHEEKERLHITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPV
AGVVRMTNGKDGEEVENPIQCCLQENRQLSPDYALVLHGRDGRCFDIQQSVSPLKTIDGN
VMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALV
FLDLDRFKAVNDNAGHAAGDALLKDLSLLMRHHLRNSDCLARLGGDEFGLILFDCTREQA
QSLIQQLVNHISQHPFFWEGKIYHVGASAGVTRIDADAGKSSELLAQADIACYTAKHRGR
GQVYLYEARQKMILERQHELLTRQEVTDIINDGQLLLHVRAVAPPKTPLAVCFYQLKLQV
RDQDGQALASDDFISAARLYDLTKEVDRWIIGQILTQRAPDIARKGLSIALPLTTDSLLD
ASFQDDLLAALDASPLQPGALLLAVDDAVVLEHAGICRPFLQQLQQRGCKLIVNGFGHSL
NAFDELHGQKIDYIRVDERFIINVHCNQMDELMVSMLNGATHRVHAQTLAGPAHQQITLN
TLQAIGIDLSDGDAIALEQSLTELLSGGYFGIR
>A0A3N1J6X0|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. BIGb0383|TrEMBL
MPGVLLARRVDVRGQYQGAYVRRDNRVKHPRWLAQLSQQSRPGRVVNLCFIIVLLLSTVL
TWREVAVLEDAYVTGQQTSLVNVARAFDAHMQLSIDDIRIYHDSMPEAINAPLPFEALRH
AKNDFDALRKLPEWVISLDVMRTIPVKGVSDAFVEETHLLSRAHPWLENELTATLELGYL
MYLSRHASRFAWRTQYISRAGFYLSSEDLHNTDGTDILSSYYSRESEPWMVEQTPQANPS
RKLRWYSAMTPEVTLTASMPVDYRNQWLGVLAMDFDLSAINTFLANAAAGEGDGRFQLYD
RHMNLIAWSGDVVTLSERENARLAGAIAKKSRGGIRFTGGYVSWQRLADFDGVMLRFHTF
GEGVRSDFGTISIALTLVWLLFTSMLLISWGIIRRMVLNMSEMQRSLEWQAWHDPLTRLY
NRGALFERARQQTNLCQQRQEPLAVIQLDLDHFKNINDSWGHQAGDRVLVHVGGLIGSSL
RGGDIAGRVGGEEFCILLPGTDLADAYQIAERIRQRLNSKEILLSRGTTIRISASLGVSS
SEEHQQYDFEQLQSVADNRLYRAKQQGRNQVQATD
>A0A221WBM3|diguanylate cyclase|EC 2.7.7.65|Actinoalloteichus hoggarensis|TrEMBL
MSAVRTAAQRELGSVWGDVVAELPVGVLLQNAGGEVLAANELAAMLLGRSRPELITGGLR
VEHVLRDEAGAPVPRSHQLIGQLTRRPGLLRLPLVRVGAHGIETRLWMSFQVISLHGSPV
LLSFLQPVDGEPARRAGVIDPLTGLPNRVLLLDRLHESLVRADIRGTMVTLVLVDICRLA
EVNAVHGFERGDDLLILLADRLKAGLRADYTVARYGSDEFAIVAEHPRGSGTAIAARVND
VVGSPVFLGRVRLRPELRTAWVTSDGTLPSVAMLDRAETILRRRG
>A0A2S5C5P1|diguanylate cyclase|EC 2.7.7.65|Lelliottia sp. 7254-16|TrEMBL
MQRDVFKAKTHFLERLRHHPGKIVNLCFVVVLVFSTILTWREVVVLEDAYISSQQNHLKN
VASSLDRQLQFSIDKLLFFRHSMGDALQTPLGFRVLQDAVGSFNRLRAEPFWQLDVDQQR
TLPISGVSDATVERTTLLARDNQRIGNELSAALEVGYLLRLATSTTGKEKRVYYVSRAGF
FLSTEPTAQNHTVISRYYDLVTSPWFTQQTERQNRSRGVRWFMAPSSGAQEERVITASLP
VYLDHYWYGVLAMDFTLPTMKQLLTDAVDKRTDGEYQLYDSRLNLITTSEPPEGLINQFD
ERERAQIAHAIEGDTQGGIRLNSRYISWERLDHFDGVVLRVHTLQEGVNGDFGSISIALA
LLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGALFDRAKTLAEEC
RQQKIPFSVIQLDLDHFKSINDQFGHQAGDKVLCHTAGLIARALRSTDVAGRVGGEEFCV
VLPGATTQQAAEVAERIRAYISSKEILVKKSTTTRISASMGVSSTEENDNFDFEQLQSIA
DGRLYVAKQQGRNQVVWRDADKK
>A0A635JCA0|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
ALNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A395L9T7|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MSFLPALSIISLLVMLPVLLSLRKASTPGAAEFASGCVTTAVAMALVMVSGLPSLQPLAL
VGYAFLAVACLFVLAGFQAFFALPGWWPAILSLGTTLAATLSVLVVSGPNSYAARTLIAL
GIAAAVFVIASISVPRLRTASDPKTRRAIIVGAAVAGATLLHIAADVPAAIVDRPGPAAE
VAWNFALSAMWLLYMPILYLGVILMAHDRVIADLKTTIARDELTGALSRRAFIDLGERQF
ASCLARTRPATFLLLDLDYFKQINDRYGHAAGDAALGHFAGIVAACLAGRGTFGRIGGEE
FGIVLSDHSEGEAFLLAEEIGRTVRDTPVGRFGQPIRLTVSIGIASASTGDTMTDVMVRA
DMALYASKADGRDRCTIAGRLQPDASARVLAAAAAQLRAAEDYSHAPQLLRDTG
>A0A7L6C0N1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-01013|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDIGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A2T0BAC7|diguanylate cyclase|EC 2.7.7.65|Clostridium liquoris|TrEMBL
MGKELLIFLLILSIGMIFIQLIRIKKMKKYIKTIKKIRETLYDVSYTISNTDNEEEIYSR
ILNVSINLIPYASKGSILILEDNNRFYYKTLVGYPKVLQDISLTKEELFINNIKSKGSII
IKNPSKFDENFLSKEKNNKLIKNNALDISCTISSPLYIDNSLIGLLNIDSTSYNKTFTEE
DRMFMDYIKNELELVLKNSLTQKKLRYMANYDELTGLINRRRFKDIFYSGVDIVKNQGTM
LSVVAIDINNFKFINDTYGHNVGDSVLKAFAEVLKNNISKEHICARIAGDEFIILLKNYS
LEESRNKMEEIRDTLSDLNLHNTNLDFSYGVYCVTDRNNISPDDILIKVDRQMYKYKKIW
HCNV
>A0A8H8X4A4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MSDIILARVSETLSTEQSLDSLVRQLLEMLEIVTDMESTYLTKVDINARLQHILYARNSK
QMQIPEGFSVPWDETLCKRAIDSDTLFSNEVPDRWPECEAAKALGITTYMSVPVHLADGS
LYGTLCAASTAQKQFSERGEQVIRLFAGLIGQYIQKESLVLQLRVANAALIAHSYTDALT
GLPNRRAIFENLTTLFSLARHLNRNVMMAFIDLDDFKRINDQYGHEAGDRFLVQVGKRLT
HEQTQDEIIGRLGGDEFLVASLSHSDDGDASTEVNAIKTRLNGLIAGEYGLGNATILYPG
ASLDVVIVDPHSTDEDSALRTADLAMYQDKKGKSKTGFVALD
>A0A144AL49|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MKAPATPENETERLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPGTVPRNISFCGHTILAEAPLVVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSVARRRAEPLTLGWLDLDRFKEINDRFGHEEGDKALKAMAQLMRASFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVESYNARKLHPWSLHFSWGLSEFDHNGNDLQ
QWLKEADEKMYAMKQQRQRAR
>A0A7Z0VQ63|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MAVLFLCLFTVDVYLNYRPISVSGNPAAESVAVSPADLQLNLPQRQPDTGEVTSADVGSD
LQIESHANKQLLAIVKQRSIFYALGFLLGLILFSWLLNKKLLFPISHLKQVAKELARGNY
LAAANLPEHDQLSHVSQAFKSMAEEIAKREELVNRQKALYAALSQTSKMILRNRSPRVLF
ERVCDIAVTFGGFNAAWIGEVNEIGKNIVPIASAGINLESLKACTFELDLTNPKADSPLA
ISAYGKCPSVIDEIDVDPGKTPWHRLAQLSGSRSAAVFPIVTNQLVVATLTVYAQERHYF
TLTIHDLLDEMVKDLAFAIENYERTQAHKVAHKSLEKSSGQLEAVNKKMSLILESTGEGI
FGIDERDACTFINKAAAEMLGYPQDELLNQQIHKRVRMFDEAGKSFNSAVLQRGESVRVK
DESFLRKNETLFPVEYSTYPIKEEGRFKGSVTVFRDVTSTRSMMREMRFLATHDSLTHLL
NRHAFDQRLRQAFANCRDHGMQHVLLYMDLDQFKLVNDTCGHVAGDMMLRQLSHRLQRTI
GGDDVLARLGGDEFGLLMENCQLDRAQRLATKICSVVKDFRFTWEGRTFSTGVSIGIVAI
GPNTESPHSALSSADAACYVAKDMGRNRIHVFQPYDEEIKRQQGEMRWVGRIESAMDQQR
FSLLQQPIMSLRSSAIGDEHIEVLLRMQDERGKQIMPGAFIPAAERYNVMGSLDRWVISH
AFRWLSENPQRLDELGLCAINLSGQSLGDGSLHEHILEQLRKFNLPAEKISFEITETAVV
SRLDQAARFISLLKRRGFRFALDDFGTGMSSFSYLKRLPVDYLKIDGSFVSNMVNDPVDK
AMVESINEIGHLMGLQTIAEYVEDDQTLEQLIDIGVDYAQGFGVVRPMPLQMAGSGPLNA
A
>A0A240EI87|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MTTMTLELSDFHWTMQLLDTLDAGLIVVDRQYNVCAWNSFMQHYSGINAESIMGQCLFER
YPNLPEKWLRAKLESTGTLKTRGFSNWEDRPIIFEFKNFSPVSQGLLNMYQNMVITPLKS
PQGEVTHFAIMLQDVSDIAKSKMHLKHSNEKLTELGRTDGLTGLFNRAYWESQFIDEFHS
VQTTGRTSTLVMFDIDHFKQVNDTYGHAIGDNVIKTTATQLLKAARGSDICGRYGGEEFA
VLLTDTTADQASYFAERLRKRVESLCLEFDGQSLQYTISLGITECRPYDNNHVDWLKRAD
KALYQSKELGRNATSIL
>A0A240EJN4|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MLTVEYDLAGEDVAGLDQRSGPVGVLMFEGKISPLSFKYHDKRVVCWLTRNISKRHRLEV
KLRKQSESDALTKIANRRHFFSTLSAITKSTTPHCLLLKKVNDTYGHLAGDKTLKEVVTR
VKNIIRPGDTLARVGGEEFALLLPDIDEYAAFEIAERIRRAIADEPFHYEEHTFAITLSV
GVTQARYQEKNNLIFIRADDALYIAKSPGRDLT
>A0A8I2CJW1|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MIRPSPALFGSFRLRLAILFGGLFLASALLAAACLDQVLSDRIVRDQGEAMNSLAANIAK
AIESNLRERHREVLLLAQTPTYVRAPLDGDDVRQSLERTKQAYKYYAWIGITDAEGKIVS
AAGGMLVGQSAAKRPWFIHGRHAPFVGDIHQAVLLAKLLPNRSPQGEPLRFVDFASPVYD
PSGKLRGVLATHALWDWVEDIIRERLPPKSGLETFIVDRQNNLLSPFDAVGRMQAPTPMP
SGQTFRLGPWPGGGNYLYSESRVREAGLDWRVVIRQPRQQALAALNRLRGALMLLGLAAS
ALLMAAVYRLAASFSRPLEQLAGVAERVGRGDEQPDWEIRGGTQELRQLSDSMRNMTATL
LARERQLADVNANLEQMVADRTEQLRESNRLLVQKATQLAQLARNDALTGLHNRMAANEQ
LQEEHLRHGRSGAPYAVLLLDVDHFKRVNDTHGHDAGDRVLRHIADILRRAARATDFVAR
FGGEEFLLLLPETDADGAAVLAEKIRASVEQSQAPDVGRVTLSIGLATVVPADSQPEMAV
KRADQALYRAKAAGRNRVEAAARED
>A0A8I1YZU6|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSKFPIRFTAVAVERSLIPRPLVRQSAVSALFCLPLLLSVPLYALAADQHALLLGQAGWL
AALGCGTLWLYGRGQRRKARATLQDACLGLLEFDLAQQYVRGSVHTLQRLLGLPAHTRGM
NCARWLMLLHPEDRQLFSNLLLHPPGTPETGYEMRIRHHSGHWEWLEMNLQPTWRNGKVQ
QLTAICRVITARKHDEAAMLQREQQFRTLVENAEDIIARYDLELRCLFINRSVCRFSDLP
LEEHLGKTPRQKGWSDEASARFEQECQLLINNWEARRFELELQHGQQRHIFEIRLFPEFD
KAGMLKSILSVDRDVTATRQGERLLAEENEVLEMIAGNHPLPQTLEQICQMMESQQPGSM
CSVLLLEEDGQSLRFAAGLSLPPAYRKLSERVAVGPSVGSCGTAAHWKRTIVVDDIQTSP
LWAHALHKVQPFGLRACWSMPIFSSDRQLLGTLATYYREPRSPSQEELALAQRITRIIAI
ALQRDGHEKQLYRLATQDGLTELNNRRQFIELADREIERSRRHGSRMSVLMMDLDHFKDI
NDHYGHAVGDEVIRHFSQVCREVLRASDLCGRLGGEEFAAVLPDTGLDDARQVAERLRSL
ASSARLSAVSGSLGYTVSIGVAERHADETDIDEVLGRADKQLYQAKRDGRNRVSGAAPVH
CG
>A0A2I8SEY3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii complex sp. CFNIH3|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
VKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTILKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRQVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A447TGI4|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MGNIIALVVIHCGSDSRINRDMLKAMTRIHENFLRLLFEADRDMLTALHNRRKFDLRFYN
LIAALQHEPASTTPHVLALLDIDHFKRVNDQFGHMVGDEVLLLMAQLMQQSFREEDGLFR
YGGEEFALLLQGNQPEIAEQALERFRATVEGHIFPQVGNITISIGHTRIVHGQLPDRLIE
QADRALYYAKSHGRNQVRGYEQLEAGGELEAPPASSQVDYF
>A0A5C1E8G4|diguanylate cyclase|EC 2.7.7.65|Oryzomicrobium terrae|TrEMBL
MSQPSSPLSAQPSATHRPMAPEAEWLALVATTPEPCRAAVAAVVRIHGPELAAHFYGAMM
ADHDAANFLDHTIVNERLRGSMARWLEEIFIQELHDEAQAAAVVAHQRHVGEVHARIRLP
IYLVARGARVLKAAIFRLLAEQNLPPEQHLRAMPYVGQVMDLALELMSAAFVRNSERSAR
ADEAYRLFSLGQNMSVERERQRSVLLEWGQEVLFMLHRPSSRAVLPNLAHSEFGLWLNHK
ARMMFEGSEELGQIQDIVERVDSALLPQLRVADPAAPQLNTLVGEFYGELDSLKFLLSSL
FERYLEVENGRDALTRLLNRRFLPSVLSREIALYRGESQGFALLLLDIDHFKNINDSYGH
DSGDAVLQQASALVLNAVRSGDFVFRYGGEEILVILVEVNADATQRIAESIRQKFDSGEF
LISDGRALHVTVSIGVAQFDGHPDYQYLINRADAALYAAKQQGRNRVCQAPAE
>A0A564SAX0|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAME
HDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLI
SWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQV
DLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILPGASLTEAAE
VAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGR
NRVCASDNA
>A0A8H9YF73|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MDLSAAQHPLKAKGVLFTHSLLSALIVFLLAYLCLTLSAESSHFTPLWFPTAAVIMLMFH
QPPRTWPLHLILCGIGMCIASFLLFGLSWFPVKLTLINLLEATVCTLLLRRILQPDDPLN
GLASWLKFVFCAVIFMPMFSALLAASLAPAPGETFWQPFSTWFISEAIGVLALAPIGLVY
RRSMLRTLNLFELLLVLLGTLTFSYLALLNMPFPFTFIILPLLWAAISLPRLEAFIICFT
TTLMITVMISLGLLHFQDRGTFLSDVTIYLPLMLILIPAHAMAMVMHAFRVEKEHIVESE
ARFRNALEYSAIGMALVSPEGKWLQVNQALCKLLRYPPETLRRLTFQEITHPDDLNADLT
QLQDLLDGHISSYTMEKRYIRSDGESVWTLLAVSLVRDPQGQPLYFISQVEDINELKRTE
AENRSLVERITLANQAGGIGVWEWMLNGDKLTWDKRMFELYELTPDQTPTLALWIALLLE
EDRERIGRQVATLSDRHRPFVMEFRIKTRLGGIRHIRGQGNTIFDEHGEPKRMIGTNIDM
TEIKSLAEALHEEKERLHITLDAIGEGVISTDREMRITFMNPVAEQMCGWPLELALGMPI
NGVVRMTNGQDGPEIENPVKNCLQEGPPLPAEYALVLHSRDGRRFDVQESVSPLKTIEGE
VMGAVMVLQDVSASRELMKKLSYNASHDALTDLKNRTSFEKRLKGAIASAAESQQQHSLV
FLDLDRFKAVNDSAGHAAGDALLREIGQLMQRQLRNSDCLARLGGDEFGLILFDCSLEQA
KLLMQQMIEQIGEHPFYWAGKIYHVGASAGITPIGATSGKSSELLAQADIACYTAKHQGR
GQVYIYEARQKQQMERRHELLTRQEVLNIIDNQQLLLRVRAASPPKTPQAVCFYQLKLHV
RPSDDRMLASESFLAAAQLYGLLPDVDRWVVSQVLERHAEDLRRKGLAIALPLATDSVLD
IDFQSYLLELLAASVLPASTLYLMVDETIVLDHPEDGCAFIRRLQQMGCKLIVNGFGRNL
NAFDQLNGQTIDYIRIDERFITDVHCNQMDELMVSMIHGAAHRINTQTLAGPAHQQVTLS
ALTAIGVDLVDGDTVALELPLSELLSGGYFGIH
>A0A5K1IBR9|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MIRWSPGIARQGLVECHRESSGLMSQDDGGQVLPDDFFASLVEKVEDVIWAVGYPHLQLE
YLNPAAVTLFGRPVQEFKDDPHLWLTIVHPDDREEVAASHECLLQQGKTERRYRILRPEG
DVVWIHDRAWLMRGADTEPLRLFGIARDVTREMAEQQRLSSTLMLHRRFMESAPDPIFLV
RVQPDDTFVFRYNNPAHRLQTGIPLEALRNQTPDTLLDASQAAAVKAHYLECVRLSRPVQ
YEERLDLPAGVRDWQTMLVPVEDAAGKVIELAAIARDITPLKEAERKSRGAFESLDQLLQ
ASPVVIYECQPTPELIPIYISSSVERLTGYARSELLGRPAWQALLHPDDAPVIMDKVKAM
LAGEGPIQLNYRLRHQDGHYLQVQSEKRLICDEEGHPVKVVGAILDITLSLRLSQRLEKL
AEQLPGFIYQYQLSPEGKGCFPYASPASLAIYGVTPDELAHSDEAAFSTIHLDDQAKVKA
AIEASAETLTHWHCEYRVIPPKGHQLWVEGSATPERLEDGSVMWHGYISDVSERKRLQLE
LEESEARFRRLATVDMLTGAPNRRHFMHCLEAELTRVKRHEVDACLVMFDADHFKRINDT
YGHAAGDDMLKALVSTGREQLRTPDVLGRLGGEEFAILLPDTSLEGAVTLAERFRQAVAV
MQVASDDASIRMTISLGVAALSAKDTSDSAMERADKALYAAKTSGRDRVCRESDSTGEAT
IG
>A0A1V5EBZ8|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MRRNERGSQPSRIFSRCGGHERTNKLTSKELQKENDLLTQRISELERSKFELRQAEEALR
ASETKFRMLYRSITDAFAAVDMTGRILDCNESFLTMLGYGAEEIGRLTFRDITPATWHRM
EADIIRDQVLVRGYSDIYEKEYARKDGTVFPVELRTTLLRDAKGIPVIMWAIIRDITDRK
QKEEALRKSEARYKRLAENSPGVVYQFMMDDEGRYSFPYINEKLLAVTGVSSLEATHDIS
VFTGRIHPEDLPKFHADILASATALAPYHAVFRFRREDRYIWLEARSTPERMPDGSTLWD
GFFLDISERRQEREELLRTQFAMDRAPDSVLWVDDEGRIIYANDTACTWMGFTREELLDM
KIFDLDPDFPPSQWEEHKQLMRNRGTMTFESHHVTKDGRTFPVEVRSNYFEYGDRWLTCA
FDRDITLRRQAQEEREQLIAELQKALSEVKTLSGLIPICASCKKIRDDRGYWNQIESYIR
EHSDAEFSHGICPDCAAQFYATMKKP
>A0A4U9V018|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MLAQSSYPLAFCLIDIDNFKRLNDTYGHDVGDRVLVMFAQSLSNTFRSSDIFCRYGGEEF
ALLLGHCSLENARSMMEALREQTQQMCLELLNGKRVRFTISCGIAAVGNLAELHPAIKQA
DEALYFCKKSGRNRVSIYTPTGFI
>A0A653L5K6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 8I-beige|TrEMBL
MREIRSEYLSQKLYIAMSIIILSLCSLSIPLMVKSYRDYIKTNQALTEIQALQAVADLAN
KISRERAPANKLMSSNQQDFAQHVLELKLYRLTVDEQMQKTLEVLKHSNLPNLDLSLFDR
LDEALTQGRQQVDAYAALPREQRNAETMDQAILKMFNAWDRSHDILKDVIAVSEGKDTAV
SNFYVQILLLADLRDQAGRAASNVMAHVAFKQPIPETNLARSLQTRKQVMYLWELIDTLQ
PERDKTEEFKVLHQAVYNEFLAKGLLIVERLMNESIYHRPYYLTGTQLTEAIVDKFSTVV
ELQNYLLKYSVEKAIIEKHKAQNILLTTVGISLISIFAALFTMIYARKRVFSPLIQAREI
LFDLSHSSLRPNPMDTKDQPANVYSLFTAIQQLKQTLQQRDALEFRLKNIAHLDSLTGVA
NRYALNEYIKLLENQPTQFSETCLMVIDIDHFKQVNDVYGHLMGDQVIQFVAEKLKENIR
TSDLLVRYGGDEFIVLIENVGMERALKIAEKIRSEIYEAKSVDNVRCPDLKVSISIGVAI
GATSWMALLEKADRALFQAKEQGKNKVVAYSVDEVNESYYI
>A0A8F4W9F4|diguanylate cyclase|EC 2.7.7.65|Modestobacter sp. L9-4|TrEMBL
MQLTAHLPADQLAGSPAMDAVTLLPSRVTLLDRIAERAGTSAEAPASLVLIGLLRRDSIW
PMPGSHLDRVGAALSADLRGTDWLARSGPTEFAVLLDGAAHDAETAANRLVATVAAAGVE
GVTACVGIAGLAPDASPSEVHRRATLCLTAARSVGAGRVIRYSGGRR
>A0A8F4W855|diguanylate cyclase|EC 2.7.7.65|Modestobacter sp. L9-4|TrEMBL
MNPFRRAPLTAVLVATLLALAATGPSSSPGSVPEWDNLVLALVGGWAAWHCRRLTRQMSR
RDRLPWQVLGISSLVFTVASLATGLGIGGGIGALGPGDLLVLVSAFGPPVSAALLGGRVR
GTNWPLLVVDGVMVAFALVVVADVLVLSPALSPGAVRADLIPLVAGYGAYPAVAIGVVGA
LCTVSTKAVRRSATAVIAMTALVGAGSALQAVYIVVPSAPWAWAADAAVAAALVVSVRAV
RLAVDAAASSSPADATPGVNAAGVAVQVAALVGVPITLLTAIVRDMPLHDGAIACTAVVI
TMLLVRIVLRIRESGRVQAELVRSEEDFRGLVEASSDGVAIVDADLRLEFTSPAARTLLG
VLDSDLHPSLLDLLHVEDRARVRLELAVGTGEVAPALHLRVQDAGGEPRELEVTHHERPG
SGRRVLHLRDVTTRRRRERELERMAFTDHLTRLPNRAMLFQEMAAVTSATGQRCLLVLDL
DGFKAVNDSAGHEAGDLLLVEVARRLQSLLRTDDLVARLGGDEFAVLVAGAEEDAVEAAG
RVVDVLAHPYRVGNRSFTVGASVGLAQLHPGGGQHAFRLADAALGEAKQAGKGCWRVHTD
DPSARATASSDVAAAMDAGEVQLRYDVVTTSDTGEVYGLHSTPVWVHPVLGVLPAPELWA
AAERQGVNGALQQWLLRQACAEVAALDGELTLGFDLPAGQVRADELAGEITAALAEAGLA
PRQLALAFDEEVLQTSSAGLIPALHTVRAAGVHLCLNDFGMGSTLWSQLARLPLDTVQVD
VRGLAAPGDLDRTMRVLTAIASSAAAFDVYTFASGVGSPELLAAIGAACQMAVTGPVLPS
GLTAGQVATLLRHPSTTLPTPLPVPRAHAQA
>A0A0U5MED0|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MDVSQTIKGLFHSAVDAICAHRDGTIVVANPAFARLFGYASADDMAGKRVLDTLAPEERE
RIGEFIRRRATGIDAPSFYAATGLRRDGSRFEMEVGASMFQGDGESFCVAVLRDISDAAA
AKRHLVESEERFRNLFKLSPDPTWIIQDNRFVECNRAAVAILGYPDEDSLKNVHPSELSP
EFQPDGEASFTKAERMMGLTMANGLHRFEWTHKRRDGSLLPAEVTLSATLLQGKPSIYCS
WRDISERHQAEAQMRLAAGVFDSTQEGIVVTDIDGTIVSVNPAFTRITGYAGCEVIGKTP
AILKSHHQDQNFYRAMWADLRARGEWRGELWNRRKDGEAYLEWLTISAVNGPDGKPARFV
AVFSDVTELRRKDDQIRHQAYHDALTGLPNRFLLGDRLDHAMEMARRTQAQVAVLFLDLD
RFKIVNDSLGHHEGDKLLVEVARRIGQTVRKSDTVSRLGGDEFVVVLGTFSDSTEVALVA
EKIIASLSKPLRLSGKAVHTGTSIGIAVFPQDGEDAATLLKNADTAMYQAKAAGRSCFRF
FDRSMNALAVRRLELEAQLRQAMEAGQLELHYQPKVVVETGALAGLEALLRWNHPEQGWI
PPMEFIPLAEESGLIIPLSYWVVEEACRHLAQWRKAGIQAKVAINLSARQFHDDKLPQRI
EAILQRCKVPGSALEIELTEGSVMDEPRRAIVILQRLRALGLRISLDDFGTGYSSLAYLK
RFPISTVKIDRSFVMDLPDDPEDAAIVRAILDLARGLNLDVVAEGVETAEQMEFLRAAGC
GQIQGYYFSPPLPAAELGEWLRKKP
>A0A5F1HK03|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E2562|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSTSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSL
>A0A0M7LBD3|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MFRINLRHLILWISLLSVVLALMGSLHASYLVQRDLLLRTALELNQAYASKLASVTEVFL
TDLRNYLSYSAEMLADMEVHPEHMVAETQRQERQLGQFNSTFVVSPQGKVLAASTSDRAL
LGQQLNSEAVRRAQATLLPTVSPPFMDLKNRWLILYTHPIFSADHRYLGFLGGTLYLHEH
NMLDHLLSQHFYRGDSSLYVIDRNGTLIYHPDRGRLGQSVSKSDAFAPALRGETGEMRFT
DDDGHALLTGYAPVPGMGWSIIAQRHVDATLQPLGDLLLTTALHTLPLLLLSVACIWLLS
RWIARPLGELAGIAKHMQNADSADRIRDVRSWYFEAAQLKRALLAGLSSIHHKIRDLRRE
TTTDTLTGLLNRRGMDEALALLQAEKQPVAAVVIDIDHFKHINDRYGHAVGDRALQSLAK
LMGEGSRSGDTVARAGGEEFVMLLPGAPLEAAIALVERLRQRIATEPGAVATPLTISAGV
AAYPAHGATLDAVLQRADQALYYAKNHGRNAVCVADDDAQAGARRASPA
>A0A0U5HYX1|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MAITPESVLSSIVLLTEQRSQKHLEDCLTATLAELANLPFCGICTPMPTANGIFVDWAAI
RSHDGANPSDELQEIGTDPLLLDCMAMGCERSETLADGGIRRAHPVIDDRGKVCAFLVTH
TAPGQAEPSGLIKGFIAIYRNYLTILWDAARDTLTGLKNRKTFDENFSTIVAESRHIDVS
FNGNRREAHLDGQHHWLGIIDIDHFKRINDTYGHIFGDEVLLLLSALMRKAFRAEDRLFR
FGGEEFVVLLAPTTFLAAQAVFERFRATVEAFAFPDVGRITVSVGFVRIDCDDKPSVVIG
NADRALYYAKAHGRNQVHSFEHLVAQGDLPFESPSLAKAKLF
>A0A735ITI8|diguanylate cyclase|EC 2.7.7.65|Salmonella typhisuis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8J7VRE3|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MFRTSSILPGLLLGALLLLAAWAPSARAADAWAPFESLWFEHVTVRDGLPHSTVTSIVQD
RHGLVWMGTFGGLVRYDGHRMQVYSEDPDETRGLPDVYARTLLPLADGSLLVGTNAGGLV
RHDPRDGRFLRYPVGGPGGTADAKIFALAAARDGGVWIATEAGVDRLDPASGRIAAVPGP
GEVPGMARRTFTVLEDRDGALWVGGDTGLFVRRAGSDRFVAAADGQPAAAAAALREQVWA
LHQDRAGRLWVGTGRHGVLRIATDGRAVLPPGLGGDGPISRRTVRSILELDDGEVWIATD
GAGLVTVQPDGRVRAVRHDPALQSSLPGDITRAVFQDRSGLVWIATEVGAARHDPGARGV
FSMLASPLQDTTLSDPNVHTIFVDPRGRIWLGEGMGRIDVLDLAAGRLHRIALTGGQAGR
DVQAFVIGPDGAVWAGAQGIARIDPETFAVTPGLLPDLEGRLILSMQRDGERVLIGSYDG
VHRYDMRSGRLEQFLGDPDDPRTLAGNQVRAITRLDGRWWFSTTTGASIADLDRGEFVTL
RHDPDDPATLPQNYTGAPVEDGRGRVWMPTFGGIGVGIRTPGRGDGWRFDRIGGDEGLSN
LKVNALLLDDAGDAWASLANGLARIDGATLQAQDLGARDGLRVASYVHRAAARAPDGSLL
FGGLGGLTVVRPGTHPGERERLDVPLAITGLRFDDAALPADALPAAGGALAVPAGARSLH
VDFALLDYRTPAEIRYAYRLVGFDDAGWTQVPRGAPPTATYTNLPSGTYTLELRATVRGL
HGGAVVEGVEVEVAPHWHETLPARLAMAVLVAASLFGIFHLATLVQRRRARRLERLVRHR
TRDLQAANARLDTLASTDELSGLLNRRRFLQLAEAERRRAMREGAGFALLLIDLDHFKAI
NDTWGHPAGDAVIAAAGARVAAACRADDHVARYGGEELIVCLPGAGAATALAVAEDVRRT
IAASPVDYSESGTAIRITTSVGVAVWHAPDEALAALLQRADRALYAAKRAGRDCVVAAD
>A0A399ERW9|diguanylate cyclase|EC 2.7.7.65|Meiothermus luteus|TrEMBL
MAVETLRDEDLRLMELLKRMREELEQPIPHLEALRSDLGKALELLQVRNEALLRARGASL
QADPLTGLLNRGAFEEALAQVHQSGEVFSLVWVELDSLPGVAQRLGPQVAEEALRRVGQL
VRRALRASDAAARVGEGELALILRGISGDRAFGVCERLRVAVLKYPWQTLHPDLRLTLSL
GLASREDEPSSEAVAERARRFLAEAVASGGNQTFPGFYY
>Q0T4K7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTSVLIVPCMLTL
AIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLGANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A7L6U0G9|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C21|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDQQKHTIMHGPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A3S9L0Y3|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MDAYTLHIATAFASAMMTISLLGLFIASPREYSLLDWSFAGMCFFTGNSLTVLVFHYPQP
FWVAPTIINACYFAGHCALLMGVRRYFGLKTYWLLALALAVFAASLHLLPWLQESVNNRQ
IVLLPMLMVLNLATVATLWRHAPGELRLACMPLMLLELAFFLQLLLRTAILHLDADLNLT
MTGSQFFQTSGTLAIFVLLSLGTMACALMVIRRQELELRELTIKDPLTGWFNRRALNDIA
VREFERSARTSSELGLLVLDIDHFKKINDTHGHVYGDAALKHVTQTCERLLRGYDYLFRF
GGEEFVILLPGSDHDCTRSLASRLRQKIQGEPLVLADTQVLLTVSIGVAQRRERDHNWLQ
LMERADAALYHAKQSGRDRVAFHNGMELSQVF
>A0A3S9L9P1|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MDIAAFALTTIGLLALLASLPTLWRICSLPDFHNRAWCTLLVLVMGFVMGYLGYLWMILG
HEVTQLELVVAAIFGGGGGFVYLVTKLSANTIRRLLDTLREKRFQAEHDLLTGLPNRNAY
YQKFDQLLQEAKPFACMIMDLNDFKIINDTYGHHIGDRVLQETCNRLLSLTPSSALCARL
GGDEFAMLLPGFTAQSARELCQQIHFQLKQDICFDGLRVAVGTSIGISQYPRDADDKKQL
MKFADIAMYHAKRMEQHTAIFTPELTLQT
>A0A399EWL2|diguanylate cyclase|EC 2.7.7.65|Meiothermus luteus|TrEMBL
MQGEAQSIKRGFYLAALLVALPVVGLTWWLNQEHPYVRYTYPLFLGGFCLWAWRLWAGAR
LERIEREVILAVGLVFLGKLAYGFFSPEPDWSEIESAYWVLAFVMVLVYLSFSPRQGLWV
GLGVVGLTLVLGLLRFGGEWASSEFLSFLRSETRLLAMAGLLYLLAAVKDHLARANRQVE
EMHTLARTDPLTGLPNRLALSERLEAEIQSPHGLFLALLDVDHFKQINDRHGHATGDAVL
KEVARRLQAGLREGDVLGRWGGEEFMILLREESLQNVLAALERMRESIAFWPFEGVGAVS
ASFGVAEAQFGDTVHGLLERADQALYQAKRMGRNRVELAGLSP
>A0A645F9G6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLYPWVLTLWPSVALSLLLFYLFFLEQRYSIDTLTGLRNRTMFMHDILDLQHGSRDAAAI
VVLDVNYLKKANDTYGHKAGDELLVHAGSLIERCFRGLGKVYRVGGDEFAVVSTKIDDKE
IERALVLLDVQIQLANTTRTIKLSLASGTSWCESCIGNLFNTYVAADNAMYRNKEAMKRR
PSDG
>A0A645E5W0|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MRAVKQNSAIGLLMMDADRFKQINDTYGHTVGDRVLQAVASTARKQLREGDIIVRLGGDE
FMVVLLGANRHDTLEVGEAIRRSIEEKRITYGNQEIRITMSIGGASFPERDASSEEDLIE
AADQALYLVKESGRNRASV
>A0A822PTN8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A378SI07|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MSASAVTSPVEGRVTDTPDAEYVRGMARLLQAVQELSLARSLPEIQRIVRTAARELTGCD
GATFVLRDNGKCYYADEDAIAPLWKGSRFPMEICISGWAMLNREAAIIPDIYLDGRIPHE
AYRPTFVKSLVMAPIRKLDPVGAIGNYWAQERQPTPREVSLLQALADATSIAMENVQIYA
ELEQRVRDRTAALEQANEEIRQLSLTDDLTGLNNRRGFRLLAEAALLAARTHGHDCALAF
LDVDGLKRVNDGIGHDAGDSLIVDVARVLRETLGPSAIVARLGGDEFCTLVPEYSDGAAA
LTARVQDAFRRFDARSSRPYQVMISVGVVEIPPTDVSPLEDLLSRADELMYAQKKAKSCA
EIA
>A0A174BA78|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pseudocatenulatum|TrEMBL
MLLLGTDALSWYFRVDADETAYYMVRISNFSVFCINYIFMSFFATYVWLTVSKHQHRKPA
ALRAVYALSVIGILLLIITQFTGLFYYFDDHNLYHRGNFYLLSQAIAVLGIALCLFMLIS
YRKNLDRIIFLSMMSFFVLPVLATIYQALAYSFSLQCLAIVISTQIMFVMDTVEMNMRFH
SQQAAYEKARYEAEHDGMTGLLNKEAGWKHMRKYFDRMDSHDEAMLMFVDIDDFKTINDT
YGHTVGDFWIREVASQLRHIYRQDDIICRYGGDEFLALIRNTASEQVLETTLGMFFQQLA
RTSEQHGQDVHCSVGVCRIAAADGASLGTGRADGDAIGSVDFDQCVAQADLALYETKRFN
KGTFTVYNYDRSQPAPANIRA
>A0A378SHQ4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MPRQLSVVAGLRHWWRQADHYDWFADYLSARGLVGLARVITAVTAAGLALVAATVMLSPG
GPTGTLDVTLGWAAVALAFGCAAVRWSIWPSKRQSVVLILALNLAIALFCQVQTDQLIGV
VGATAFATTGISIACLHSAKYMLYNVVVAAYIGGLQAVRAMGETDGHLIVAALGLVLIIN
ISVPFSVQSLVHALGGDVVQSDRDPLTGLLHRRALFRQINALLLSHREHADFLAVTMIDL
DKFKVLNDTYGHSAGDDALVGVGQALLTAANGRALVGRVGGEEFMVAELCETAHDTGLSE
RLRAAIAALPQHITGSVGTAVASINDVPTDDFQDLVVTLFRRSDRAMYEAKRAGGNQIRH
TVIDLPAIPVTGSDNLPTGNRPARRTSD
>A0A3B0M951|diguanylate cyclase|EC 2.7.7.65|Roseibaca ekhonensis|TrEMBL
MSSLSAAPTALRDQPVSKIDAMDGDSPVPGHYDTIFYLIRQTIGARHVTIQLDGDPRPPA
DDHMVCLESPLVTQGRRFGTLRAYAETFESGASHLLAGFAVLVAEQHALWSEAHLDVLTK
ALTRRAFMSDLGRAAATYQRSGRACSLIMFDLDHFKAVNDTHGHAAGDAVLRAVAHVVQS
ELRRCDVLGRLGGEEFGVLVMADHITALEIAERLRAVVQATVVRDFPKVAFTASLGVATT
DDSTDTRDGLIALADARLYAAKESGRNRVQGAVDADNMADLFAAE
>A0A378SMC2|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MSRIRQRWAQPDHYHWLSGYLGDRNLQGFTRRMMGLINLVLAIVPALMVLSPSGPDTGFG
VAAGLVLSVLCALMAGVWFLHWPTRAESIAFSILSNISIAVVALSWPDPLTGLLGCITFA
ALAGYVAFFHSSHYLVMVLATAAGVAIICTADITAGGDAYLAAVAFMMIAVAVLAVPFSA
QVLVHLLGDDALHSHTDPLTGLRNRRGFYRSVRRLLRAAPDRDLNFLTVAMIDLDRFKQI
NDTRGHATGDRLLVSISGCLCHCARGEAVVGRVGGEEFLIAEATRDDDAEALAERLRLAI
ASTSWGITASVGVACRRLNGDADTRELLGDLIEAADSAMYEAKRSGGNQYRRARESAA
>A0A378SR98|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MQRDQRHSDHYEWFSDFLDARGVAMYVRAGLAAIGLLMAVSSVILALGAGGPTTQPYVAM
MWTAAAGGVAGAALWVRRWPTRRQSAAFAAVTTCSITLACLAYPDPLAALLGCITFMTIG
AYLAFFHSTRSVLCVVALAVVVASVHAVELAMAGRPALAAVDLFIVVQANLAMPLAIHSL
LRALRGDLVHALSDANHDPLTGLLNRRAFRTQTLNLFDRPGDARHLVVALIDLDKFKALN
DTHGHHVGDQALVAVADTLRATATSSAVISRSGGEEFLIADVAPTDEATKRYQGLCEAIA
ALPIPVTASVGTATAALDIIADRDPDDVVDHLIAAADMAMYRAKRNGGNQCHHHGSWPAL
GSAP
>D8PCM5|diguanylate cyclase|EC 2.7.7.65|Nitrospira defluvii|TrEMBL
MGILIVDDSTDDRLLIQSILANAGYEETFVAESAAAAFRLLGLDGPRQMAGRVDLILMDI
VMPATNGIEACRQIKAVERYRDIPIIMVTVKTDPVDLQLAFAAGAIDYVAKPISKIELLT
RVRCVLRLVHEIERRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAARESTPLSLIMLDIDYFKTYNDSHGHQAGDECLRQVAQLISSHVNRPGDLVARYG
GDEFVIVLPGTTVDGAAQVADTLRRKVCEAEMKHPNGDPVTISLGFACTVPSRVAAPTDL
IRAADQALYQAKQEGRNRAKQAGVLTLVHHTHKD
>K1ZKV5|diguanylate cyclase|EC 2.7.7.65|uncultured bacterium|TrEMBL
MDDRHTSSRTGMKILIVDDSIHVRLQIQAFLAAGGYRDLIFADSAAQAFAYLGIAGKPFA
AAEVDLILMDIQMAGTDGIEATQTIKSKSAYKDVPVLMITGEDTEESLEKAFSAGAVDYI
TKPLRKLELLARVGSFLMLRQETIKRKEREQDLINLTAELRKANSALSRIAELDGLTGIA
NRRSFDQMLQREWQRASRSGEPLALLMIDIDHFKLYNDNYGHLEGDQCLKQVARTMSEVI
QRPGDCIAR
>A0A0A8UYW4|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MRLRNSNKTTLFHGKKSTRTSPSNKILADQVHLLYVQNPFGIAAQSGAAIFLAIAIWPVV
SHKLLFGWLIYILLVSFFWFGISMSYKIKKRQHDPVVWLRWFSIFTFLSGCGWGFASSVL
MPTESLVHQSFVVILIFGLTSGSLSFFSPVISTYSLYLFPAFIPFTLWLFWQGNIYILLG
FCGLIYMPAVFISCYYSNKILANFLSLHYKNIDLDSLNQSLERRVAKRTHELEKSLAITK
STLESTTDGLLVIDLKGHIEYYNQNFIDMWKISEKLTVKSDPFILIDEILHQLKHPQEFL
AKIDELRVNPELEIDCEVVLTTENIFEWHSKPHKLRHVTVGYVWSFRDISMRKQMEKQLA
YQATHDLLTGLPNRTLLYDRIHQAIAYAKRYGNQVAIFFLDIDNFKLINDNLGHNPGDIL
LQKIARRLTLCTRQSDTVARFGGDEFVILFILNEKDDILQLSQKILSRLTKPLRLLNHEI
VITASIGASLFPNHGKDPATLLKHADMAMYLAKKERNNFKLFDDRLNEHMQKNLQMQMDM
RNGLIANEFFLEYQPTVDLKSGAVIGVEALVRWNHPVKGVIQPLEFIPIAEESKLIIPLG
EWIFANACQQNKAWQKQGLKPLRLAVNVSGVQLLRDNFVEFIKETLEKSQLDPQYIEIEL
TESTIMDDKKQNLYKLKQLKELGINLIIDDFGTGYSSLNYLRAFPVNKLKIDQSFTQDCT
TDHNNASLIEAIIAMGHSLKLRVLAEGIETPEQVQFLKNCSCDEGQGFFYGYPMSAEDFA
SLIAKDEKILSG
>A0A3M3XBX3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTLQAVRPKILGFISEQASAWLVALVVLLAGCTLTIIVAWAAADVYQQQVHQRFQLLVNE
RYARLQERFEDQEQRLASLQRFFTNSSDVSRAEFDGFAQPLLLRARAYAWAPRIWRDQRS
SFEQEISRQRGVPFAIRELNASGELAPAAERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RSVLERALKSGKLAVSQPMQLVGVEPAYAAGVLLVAPVSKPVGEEPIGFVMAVISMRQLV
ADGLPKPKRDNLVMQIVDTSDAQQRVLYASSNSVGSSDLIAARRLTLGDHVYALSMRASQ
IFDQANHSSMSTILAMGMLLSLLLSALLYVLVSQRQRALALVEQRTELLRLRELELRGAH
GQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFKSEAVVGRLTLESLHLALELESR
AASLSVALGKRIAPSQAMLVESPDNLHEAQEWTLLREDGSHLTVNMLTTVLLDDYGLWIG
HLAIYLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLDPQGTGRFIYASDGMRDIY
EIETGVLQHDANKVFERIHPLDVERVRLSIRLSALQLSHWREEYRVVLPQRGLRWIRGEA
TPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLKAEMHRLNR
TAGALSLIMFDIDHFKRINDQYGHAVGDGALQEVCKRISQRLRRTDVFCRLGGEEFVVLC
PHTNGDQAYSLAMELWQSLRNTSMEPVGVVTASFGVASWRVDEGVDELLLRADSAVYVAK
QAGRDRVEAERLRA
>A0A1R3TGE0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MSTTSTPKAPDIAAQILFAMRNMGVVPIPRNYNLFYEAYIGSNPALTRDLAALGTLATQE
ELDELGARYFDHTHSQLLESAREKLHSELNALLVVLQHEQTCLENYNRILDETRAGIADK
NQSSTHLLRTAISMLVDATGNKMTENETTFKNVDRHAAEMQQVRLELDEYKRIANTDSLT
RLSNRRAFDDKLASMYDTSIGLHLSALVLLDVDNFKRINDTFGHPVGDKILASVASIIKA
NVRKDGFIARSGGEEFAIILDGNNQEEIHAVCERIRTSLEKTPFRNSKSGVDYGQVTISI
GYALASQAQNPGELYARADTAMYHAKETGRNRTIFFEDGMQKNYANKSWLIYKQ
>A0A120G4J3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPMQVVRPKILGFISEQASAWLVALVVLVVGSALTVVVAWAASDLYQQQVRQRFQLLVNE
RYSRIQERFEDQEQRLGSLQRFFVNSGEVSRNEFDGFAKPLLLHARAYAWAPRIFRTQRS
LFEQDISRQRGIPFSIRELNTSGELAPAAERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RAALERAQQSGQLAVSQPMQLVGVEPAYAAGVLLVAPVSKVAGAEPYGFVMAVISMRQLV
AEGLPRPNRDNLVMQIVDTSDTQQRVLYASSNALGSSGLTAARRLSLGDHVYALSLSASE
VFDRANHSSMHAILAMGVLLSALLSALLYMLVSQRQRALKLVEQRTVQLRAREQELRGAH
GQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFKAEEVLGHMTLDRLHVAVELDAR
AEALSRALGKRIPASQAMLVESPDSQHEGREWTLVRKDGSQLTVNMLPTVLLDDHGLWVG
HLAIYLDVTEQKRAYEALAVRDRLLKKLSAHVPGGIFQFTLEPQDNGRFIYASEGMRDIY
EIELGMLQKDARTVLERIHPLDLERVRASIRLSALQMSHWREEYRVQLPQRGLRWIRGEA
TPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIYNRRYFQDRLKGEMLRLNR
ISGALSLIMLDIDHFKRINDQHGHAVGDSVLQELCKRIGQRLRRTDVFCRIGGEEFVVLC
PNTDGAQAYSLAVQLWQSLRDASMETVGVVTASFGVASWRIDEGIDGLLLRADSAVYVAK
QAGRDRVEEALMLE
>A0A5W7BHT3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2T9Q671|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWLLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A174Z7R8|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MVDLFKTETVNETVNSDILIDETMSIVTADENFEVISGNNALFVYTRYIHPDDVSRFTEA
LKDYAESGKFIVVRMLYQTGEYHWMLTRITDGGVSETRGHMYDINIMDAALITAQIDNLN
SQIERYSSYLGMCENVLFSYDILNDDFNIFMTSDGHQTMSFYHGTLNAWEEDKIKTDVLG
LNEVKELDGFCKALANGEKLFKREININILNKPGRLDKCLARGNTIVDAYGNRIVIGTII
ILESSDNHVVEELNIISDMKDPGTDLLNKRAITDYVRKLIDSQPGHTVTIAIIDIDDFKT
INDTYGHMFGDEVLCKVADILRDAVGSRGLCGRIGGDEMFIIMEGLNDNEGIRNVLRTIR
NNTKWLYHDDPRNIKITCSIGSATYPNDAKRYDELFKIADKVLYLAKEKGKDRYIIYHED
IHREYVYGMGRIVDLNDKVFYKYHKMEIVNTIIREYKEADDARRKELIDIVAVAFNINTI
AIYDRTELTKHILYGDQRMTDDDGSFFKEDNYIPNFREDGIFVIDNINFFETKAPAVYKV
YSEYGIVQAVQYIIGGDIKKNNNIISYGRFKLDKKWAESDMNFLAIIGDYIGRIFLKERK
HD
>A0A0H7Y530|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNF
ISHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTR
HLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQ
AKNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGH
ATGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPF
DLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7Z8FE22|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5F1FA97|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MFPKIMNDENFFKKAAAHGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLSGWWWLVLVGWAFVWPHLAWQLASRAVDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLKSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A8G3XJ12|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LNHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A3V8CY66|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2T8M961|diguanylate cyclase|EC 2.7.7.65|Salmonella anatum|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A418ZE73|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mbandaka|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F9IQM4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8F9IPR7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKHGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8F9N9R1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTSLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A069AEC7|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLGMTNIEIAKKLPDNIAK
FFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKTYIITMANDITK
LYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYEGHNVGDK
ILCDFVSLLNKELINSTSIIKLGGDEFIVIFSSDVDKNYVYSQLEALRENFLKVFSKYKY
LSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKFDKNDY
>A0A2V3KQU3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIAAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRQEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A4Z8Y313|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V5UKP3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eastbourne|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1V4IEE5|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MDNKLTSKEELISKMEELISNNEGPFSVVVADIDDFKNLNNLYGHSTGDEVIKKLISILN
NNLSSTDMVCRSGDEFNILLVKKGAERSFMELEEIRRYLSDNTFNLVENSDDNVYFTLSF
GVASYPRDAKNAVELFRVADSALFRAKELGKNRICLSEAESMVLKSNYFTKTQLDRLSRL
SKATDRTEAFLLREALDDLFKKYSK
>A0A8B6WY20|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGHFQLQKYVISSKIFWHPGITPVRIQAILSAIS
>A0A7I7FI45|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADHSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAAIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A0L0KGA0|diguanylate cyclase|EC 2.7.7.65|Streptomyces acidiscabies|TrEMBL
METESEPYVRLASLRQLHQAMADMNTARSLADTLQTVADGVVNALGYELACVNLVRNDGH
LVVAAFAGNPAAEALITGRVGSRDSWERRLAMGERWGDLVFIPHTEGWVLDDDDVPQWYT
DGPPPRFEDEWHPSDRLFAPMYTPPSQGGTCGELIGVLSVDRPRNGRLPGAWGREALQMY
AFQAAIAVSNARLRSNIQRALVRLEREQQALRASEESFRAAFENAPSGMAIAELGGEQHG
RILRTNDALCRLLGRPATAMRRYAFSDLAHPEDIGILLRTSAEGGRVELRLRRRDDTYVW
VSLRNSVVADAADGPRFLLTHIEDIEDRKRRELQLAHRASHDSLTGLPNSAELRARLSAR
ICQRPQSTHPAELDAMDRTYGPGAHDANGHGFDYHPAPTPTYDGYDHVHVIAPDESARDD
GTKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLGRAVRDGDTVARLGGDEFVILA
DGLGRADATDLAVRLRNEIIQPIRAEGRAVRVGASFGIGWAQCGMTADEVLKSADERMYV
EKRSRPKQHRRAG
>A0A1C3IGG0|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MKRLVGRHLEEMADIRSTRKQKIVHSFSLTAAALFIFYTWAYFQGQHYTLSVFELCFALI
AISNAFYVRKVINPEYSELILSGVLLVQGVILFLYSHAIPDRILWLYPILAAVIFINDFR
IGIIFSTSFCLFISTLITAMPNNFSLPFNSTHRFILSLFTMSLVCHTSAYYYTKAVSYIQ
RLYKEGIEDLAYRDQLTGLANRWSFERWAVEKLATVDSERSLTALVFLDIDDFKGINDSY
GHDVGDSVLQHFANRLSNNIRTRDRKSHEYDYSIARFAGDEFVLMLYDVPTRKDLDGILD
RICGLFESGCQTNERIKELTLSVGVSLYPQDAQELHELTRCADKAMYVAKHSGKNRYAYY
HDNPVSTLIEELPTNLTFSESDSSELEDCLEAKVEGNNVTLLKTRQR
>A0A0M7BJE2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MKTPATPANEMERLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPDTVPRNISFCGHTILSEAPLVVADMRQDDRFADNPLVAGEPGVRFYAGFPLRL
RDGASVGSLCLIDYSPREFSAADLAVLGDLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
LLRFTLSVARRRAEPLTLGWLDLDRFKEINDRYGHEEGDNALKVMAELMRTSFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVEQYNARRLHPWSLHFSWGLSEFDHNGNDLQ
QWMKDADEKMYAMKQQRKRAT
>A0A735J6D2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A174AEQ9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKRDLEALKEENKILSNLASHDWLTGIYNRGATETKINQLLAEKKTGVLFVLDVDQFKQI
NDRYGHIRGDSVIQEVVRILSLMTFKNDILGRVGGDEFVIYMPLAQDQSFVDERCRQIRT
RLLGIQMTSPLINGISVTVCGSLYQSGDDYKSLFDRADQLLLAEKQKKNKKPALTAAEER
RSAAKKGIDIDMALIRSELSEQELTSGAYCQDYDTFKSIYRFVERRLRRSGESAYIILFT
LTDKNGDFPMLQTRELQMDTLKSVTQHSLRLGDVFTQYSSCQYLVMVSDVDNQNAELIAN
RISETFYAETAAIKDKLLLHHCYPLKPAGTT
>A0A3R8TSJ2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLVSCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V9ZTI4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1S9JCT9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5V8AH34|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3Y7R557|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3V4R7P2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A0F0UQY2|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MTSQSWRSLVHRKYQLSLRLFLFLNATSAVFSVTNPLNSVRLFSAPLIAIFAISTGLFVW
HWRKRARKINIPVVSAIFGILWAWQIVSKFALITQDHATYLLIALLTVLFIGTLAFASNI
KAFTLHSLPTFIVCLWLSDHDIWLRMTYSFALPVVAIAIHNILQRRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPTVENGEHFVLLMDIDHFKAYNDHYGHMMG
DQALKRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARQTAERIRQKVYDLKIPHL
FNESVATNVTISIGIAIFEDEDVEGALEKADKALYEAKHMGRNNILLSEEIQTA
>A0A3U3MJ18|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3G3DYL0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379WA05|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGDPVTAEKRRAFCDAFEAINGTHGVNLTRHNYPALHGTLQTAATQCTDN
LDDALLLPAFDQAVSINRSQDDHSHGLGTLELKFRYYVDLNKHYVYFYDLINSRRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGALKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGLRVS
LSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQHRSS
>A0A3R0WAZ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A127MTH6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MAGLLIFIWLHGQALGVKSFACFVLGACLSSVQLFFLVLVAVRMHRTMKTRSKLLSSLEY
ESGHDVLTGVLNRRGFDLSLRQAMSAAGHQKKSLTLLYLDLDGFKQVNDLHSHAVGDRLL
QVVANKWSRTIRGGDLLARLGGDEFALITGATGAEVEALCERLLGVAKASLLEEFPALQI
GVSIGVAEFPRDGRQADELVLAADSAMLVAKALGKSCFQWALPSSERGRGVASPVA
>A0A486QT76|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VSRMPFENVELLHSRGGAA
>A0A0C7KBH5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A3B7PKK0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAIINELNNSIDAHYKWLVKMFRCAVSSDVTHPDITGDNAHSVCRFGKWIND
QSLNNEDGSSYVSKIYSAHEKMHVIGKELLLAIVENRSHPWHFDSFQDALLAFTSAVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
SDGEIAITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A221TBS8|diguanylate cyclase|EC 2.7.7.65|Pectobacterium versatile|TrEMBL
MSASPPMFLTVDVRRSGLRFSQRVYIPRIVGTILCALFISSVLITRPIPTLLWGLLFLNT
FIWPHIAYTLSLRSRDPMQCEKRNLLIDVVFGGIWIGFMGVNLLPSALIAAMVGMNCTAG
GGVKLLVQGIVLQCVACVLVLVLFSAPVSLDTTPLQLYACLPMLLVYPIFLGYVTYTTAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDSCQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGDALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKAADMALYRAKNKGRRRTEVA
>A0A0P8IBJ2|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFAYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKLTMLTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYQCLV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTVE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPSSVIKTSPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A083ZRK2|diguanylate cyclase|EC 2.7.7.65|Rhizobium radiobacter|TrEMBL
MTARVLVVDDIPANVKLLEARLVAEYFDVVTAEDGFKALAICDEEQVDIILLDIMMPGMD
GFEVCERLKANPNTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLIARVKSLV
RLKAVSDELRLRAETARQIGIEEMLRSDGLMQTPGRVLVADGRASSQERIIRALKPVAEV
DAVTEPQAALLKAASSPFELVIVNSNFEDYDPLRLCSQFRSLERTRFLPLLLVAEQGADE
MVARALDLGVNDYILRPIDPNELVARSLTQIRRKRYNEHLRLNLQHTMELAIVDGLTGLN
NRRYLDSHLKILFDRAAVRGRPISICMTDIDRFKLVNDTYGHDVGDEVLREFAARIRSTV
RGADLACRYGGEEFVVVMPDTPIELAASVAERLRAIVEDKPFYVRSIDRELSITASLGIA
TSSGAFGAPDEILKQADKALYEAKHAGRNRVVAAAA
>A0A486R2C5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHHSL
NALVATADRLMYQAKQKQGRERR
>A0A2U2BF25|diguanylate cyclase|EC 2.7.7.65|Alcaligenes faecalis|TrEMBL
MSQPNIEEAAQDWHGLLQKVPLAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHE
QVHKRLHRSLRSWLVQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFLFESSTISSEQAWECYRYIQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNVIDTELMPAFEQGDAKGQILRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTYGHDAGDRILRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMNITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYV
>A0A2X3CPL6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A3V9RYM4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0S4UWP5|diguanylate cyclase|EC 2.7.7.65|Ralstonia solanacearum|TrEMBL
MSEPAQRQETSPLRTDDVTGMDPCGAPSRMEPAPVVLIVDDEPSILSALTRLLRKPRYTV
LTAEGGEAGLNVLASTPVDLIISDMRMPYMSGADFLARVQARYPDTIRILLTGYSEVESV
VRAINEAGIYRYLNKPWDDHDLLTTVAQALEQKRLSREAVQLTALARKQNDELRAFNAGL
EAMVLARTEEVQRLARHDPLTGLYNRRVLAAELEAAIAESRVTGCPYLVLIIDLDRFKPV
NDLRGHRVGDIVLCEIAERLKDALRRSDTVSRLGGDEFAVIAKADRGSYAESAINLAGRL
LAEIRKPVMIDGNRIEIGASIGIASCPSDGSDAEGLLRSADIAMYRAKREARGSFRFFEQ
RMDEELREQRELEVDVRAAINNGLVLPHYQPLIDIRNNHLYGFEILARWQDPVRGAVPPD
IFIPVAEQLGLIPRLTSSLLRHACRDAVRWSNDKIRLSINISPSQLKDIRLPDQLLAILD
AEFFPPPRLEIEITETALVGDIETAKAVLSALRAAGITVALDDFGTGYSSLYHLRELKFD
KVKIDKSFVQLMQSNNESDKIVEAMIGLAKCLGMPAVAEGIEDRASLDHLIFKGCDFGQG
FYFGKAMSAEKAKALLTAFEDTSAIVDSKR
>A0A8F6PIU9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTYPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A8B5HM73|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTMPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRIDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1V3VKS0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMTHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A066RI01|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2I8SSB3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8G8S696|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCHTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>J7Q7K0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A377BY23|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLTALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8F6YQE4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEKFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A8H1XN59|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRILLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H1FF61|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLHDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENENLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A0E1II94|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A7D7HIX6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFSTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVFLLTPGDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFESLLTLAITLTLSWLSMLYLPWPYTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLASPRTYLMSHIPWLPFLLILLPANIMTMVMYAFRVERKHISES
ETRFRNAMEYSAIGMALVGTGGQWLQSNKALCKFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIVSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHTEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSTDTSRSAIEQDVVLHCRSGCSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFMWEGRLHRVGASAGMTLINDSNHQAAEVMSQADIACYASKNSGRGQV
TVYEPLQETAHNERTVMSLDEQWRMTKENPLKMIAHGVASPRITETRNLWLISLKLWSSK
GELIDEQAFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSIAGSGSLTLV
DELLEQLGQSSLPPRLLHLIIPAEAIFDYGQAMQKLRQAGCRIILSQVGRDLQIFNTLTA
NMADYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVDMPLVLNTLSDIGVD
LIYGDVIAEGQPLESLVNSSYFAIN
>A0A1Y2XZS1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAKKLQELADHNMYQAKHQRAEKLVR
>A0A376PRM8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHTSAENLQELADHNMYQAKHQRAEKLVR
>A0A376PZ38|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A089R4D5|diguanylate cyclase|EC 2.7.7.65|Pluralibacter gergoviae|TrEMBL
MRSIVIPRIACFSEAHVLRNIVWLFLLTTLFYAVGAMLRLVQELSLFWPLNAVMAGVFAR
YVWLNRIHYYIICYVAMLAYDGITTQWGSLDSLVINASNMVFIVMVAQLVMRDKRLQDTD
PEPINALRLFNYSLISSLACALVGAVASVGVNHQGFWPMLGDWFSEQFSTGVLILPCVMT
LTMPYEITGIRWRRLLPALALVVSLLAAIAVGGAGSLAFPLPALIWCAISYPMPVVCLLT
FITGASEIILVANGIINLAVDGPLQNAQLFSTRLGIASLAICPVIVASSVIAINNLIRQV
SLRADFDFLTRVYSRSGLYEVLKTRPCDTAEQHITVMLLDIDYFKSVNDNYGHECGDYVL
TALARQVSDVVGSQGLVARMGGEEFAVAAKTRNAEEGYRLAEAVRAHIAASQFQWRQQTL
QVTVSIGIGNGYTENRTLLDTFNTLIVEADDFLYQAKKRGRNQTCARETLPALQS
>A0A0B1N5S2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376PXT5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSEARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A0F3SFX2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTSALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376JY84|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKSLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5Z5IWC5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium var. 5-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Q9MIB3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Karamoja|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C6E198|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MQSLKELIQKESKKITLLIIFFLMIIVTFFNCITAKKEANYTAQTTFYHIEQILNENQKD
LNKQKKEYRQTCIDNAQAVAYSLQENPDALYNIDELKKIAQYVEVDEIHIFNKQGVIISG
THPEYYGYSFDSGKQLSFFKPLLSNQNLQLTQKIMENTASHIKMQYSALWSENKEFIVQV
GMNHENASKATKKNQLSYLFKLFRVNNEAQYYAINSKNHKIVGTTHHHIGDIASSIGLKD
TQIKEVKNGFFTEIDGQLSYCVSKKIKNNYIYCIIPVRVLFKEVPKNCLEMIVCLIIISI
LFRLLIIKYIRVYVIDSINQINHQLSKISKGQLDEEVSINNSLEFQKLSHYINEMKQSLL
VNNKKMDYILTQTNQLIGFYEYNQKLNTLYLSDGFKEIFSLNSQQCTQFKEDINDFIDFL
NKINTHQVEKDIYYLPQMKHYIQINDRKDQDNTLGVMIDITTSYIKRKKIEIERDVDELT
QIYNRNGLKIKINKLLEDKNIAQYALIFIDLDGLKQINDVYGHYCGDLYLKQMTNVLKTI
SGEKCLVGRLGGDEFIAFFHHYDSMEKLNNDINQLNEIRDQIVLLADDHSVNLAFSYGVC
YGTESTDLQRMIEIADYKMYENKRKRKGR
>A0A8E6W244|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVVSLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1R2LZ27|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S4P5F4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MRLASKQGEAGMRMSPGGDAQTLLALMHARAEVARLGEREQLFSTLMGGVNAVLWAFDWQ
AQRMIYVSPAYERIFGRSPALLLADYGEWRNAIYPDDVEYAQKSMLAVLDEGAVETREYR
IIRGDGQLRWLSDKCFLGRPGENGQSPIIVGIAEDITEKKQLEGELQRLATTDVLTQSSN
RRHFFECARIEFERARQFASSLAFLLLDIDDFKRINDTHGHQMGDQVLQKVARCGAAVLR
QSDLFGRIGGEEFAAVLPGCQPDLAEQIAERLQREIERVVFTAENGERFRVTASLGLTYL
RASDAELSAVFARADAAMYTAKRLGKNQVIVG
>A0A2A6D486|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U6ZTU6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y1IFS5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHRRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A4U8JIM0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y7JAC3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQSNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q8Z8Z3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMLLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDAGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Y4LUX2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5T6NMZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8E6JD12|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhimurium str. CFSAN000648|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A518BYF5|diguanylate cyclase|EC 2.7.7.65|Mucisphaera calidilacus|TrEMBL
MEERENRRVTADLSDGLRLTDELSVDELSLPEVAWPRHGLTTTLRGILTGGVVAAGVAGG
LGWWLGGPLLSAAAVAGVAGYAHWRLSRGVVQSLGNLIDRLELTSCNPTSELVEKLPLER
EDEIGQVARAMARVCRNSIRKGFEAQQLRRTIDQRVRLATRKATSRLQRETLRDPMTDLG
NRRFLEEQGPKLFDATEASDLSLLCVAIDLDHFKAVNDTLGHAAGDDVLVFVGSLIKATT
REDDMAVRLGGDEFLVLMPGADFDRGLKFAAQLRSLFTQQTGLLTRGGPKPDLSIGIAER
LSDRCDSLQSLMERADERLYTAKRNGRGRAEAG
>A0A853SD86|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MDSLLKHMVDMTGHRDHTMLDISVISAVQELAAASQTRVLALTTVRGQVFVRSRAIIVAG
SVARMEEHYDPTLPGEPLSDYPALAACIKRHEASADTLCADGRHLLWLPIWIGDQVTTCL
EITNPTPYTGATIQVIGGIVSVYRNFQNLLDYSERDSLTGLLNRKTFDDQLAKILQSRGE
PEAEKPLPVDAERRHHTDTERQWLAVIDVDHFKLVNDKFGHLYGDEVLILIANQLQSSFR
SQDRIFRFGGEEFVVLLRSITLENAQKIIDRFRTNVEAHDFPQVGRVTVSVGFVSINAYE
APVIILGRADQALYYAKSHGRNLACHYDELVAKGLLTTITSNDTAEFF
>G4SXH6|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MTIPKKILITDDDPINRKLVESLLKPNGYDIRSVESGQAALDAVDFDPPDLILLDLMMPG
MDGFEVVRRLKADAATGRIPIVMLTALDDDGSRARLTSAGISVILTKPLDRWALQGCINQ
LLGGCHGIE
>A0A5C5DEG7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. B2|TrEMBL
MFGNAIQRVIGRFRSPQKIVNICFIAVFVFSTMLTWREVVVLESAYVANQRNSLNNVATL
LDRQLQHNVDSLLFYRNAMHYALESPISTDKIRNALAEFDVLRTKPFWQLRPDLSRGLPM
NGVSDEFVNNIPLLERDKQTIHSELSSVLELSYIMRLSDNGRTLPRRIFYTSRSGFFLTS
TPPPNDPQITSLYNRLIAQPYFSAQSPENNPTRALKWTHTFNPNSPNGQIVTAAVPLDFN
NRWYGVLALDFPIDSLHSFLQRARYDDHDGTVLLYDNELNPIVGTREKLPEHTLFTAPQL
AKIANAVTGATRGEQGELRMDTRFITWAKLDTFDGLLIKVHTLEEGVQGEFGRISIVLSI
LWALFSLMLIVSWVVIRRLVNNMFTLQKTLTRRANYDTLTRLYNRGAFFDIARKLSKECQ
LRGQPFSVIQMDLDLFKSINDRFGHSSGDKVLAHAAAMLSDAFRNGDVAGRVGGEEFCIV
LPDTSLEEAEKVAERIRVRINSRELLLKQGNTVRISASFGVSSAFEFNDYDFERLQSYAD
HRLYNAKQNGRNQVCSKD
>A0A3S4V547|diguanylate cyclase|EC 2.7.7.65|Fusobacterium varium|TrEMBL
MSSTEAFGKKDEKSSIVWRENGTITGKIYENYDSLIKWTDGSIVHFQESTDITDTVILKK
NVIQDILCDKALNWRAGKVEMAKAIQEAKKNKKNFVVASIDIDDLKIINERYGHIEGDKV
IIETIKIIKNSLAEKEFIFRLEGDNFIVVFENRTEKEAIKLLYECIDKLKIKKKELKKSL
ISLFVLEQ
>A0A7T4NQH4|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MSKQTQHVLVTLPHPLLRLVSLGLLTFIFTLFSLELSRFDTPLAPLWFPTSIMMVGFYRH
AGRMWPGIALVCSLGSISASLVFSPAGSLNFGWTAINIIEAVVGAILLRKLLPWYNPLQN
LNDWLRLATGSAVIPPLLGGALLWLLMPEGTPVKTFLIWILSESIGALALVPLGLLFKPR
YLLRHRDPRLLLETLLTLTITLGLSWLSMLYVPWPFTCIIVLLMWSAIRLPRMEAFLIFL
ATVMMTSLMLASDPALLSTPKTYAMMNVPWLPLLMILLPVNIMTMVMYAFRAEQKNITES
ELRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQDELRALTFQQLTWPEDLHNDL
EQLNMLVRGDINSYSMEKRYYTRDGDVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
ERVNKRLMERITLANEAGGIGIWEWELRPDVISWDKRMFELYEVPPHIKPTWQLWHDCLL
PEDRAPTEKIIRESLAARLPFKLEFRIGVKDGIRHIRALANRVLDKDGDVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVVCIDVDMNVTFMNPVAEKMSGWQQEHAIGIPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGRYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKEILLTVRDTRQHHALVFID
LDRFKAVNDSAGHAAGDALLRELAALMLSMLRSSDMLARLGGDEFGLLLPDCNIDSARFI
STRIVNAINEYRFTWEDREHPIGASAGITLINNANRLAADVMSQADIACYASKNNGRGRV
TVYEAQQEQAHSEREVTSQDEQWRIIKDNPLLMIARGVASPRIPETCGFWLISLRLWTSD
GEIMEEQAFRAGLTDPELSHALDRRVFQTFFQHAASTVASKGVSIALPLSAAGLSRATFI
DELLEQLERSPLPPRLLHLVIPAHVLMQESDKAIPAIQILRQAGCRIVLSQVNRDLALFD
CLSAHMADYLLLDSELCASLHGNLMDEMLVSIIQSHAQRLGVRTIAGPVQMPLIMDALSG
IGIDLIYGDVIADAQPLDLLLNTSYFAIN
>A0A2X2WJL2|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MIKKTIEIDTILLDLNQSIDAHYQWLVKMFRCTVSGDVNQPDIFDINSHCLCQFSQWLNN
HPVHEPEEKGFVIKIIIAHEHMHTRGRELLRAIAEKRSEDHHFDSFQEALLAFTSAVMDY
KIYLLNIRSNMDILNRITRAQSP
>A0A0X8HDG3|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MSMPPQGLPSGELLDQLARAVTDNDDLESLVRPLLELLQAVTELESTYLTTIDPDERFQH
IQFAYNPHGLTIPEGLSVPWSDTLCKRALDEGRAYTDTVAECWADSGAARQLGLVTYLSA
PVRVGDSELYGTLCGASASRVAVTAEAERLLGLFANLIARQIERDRLLQKLRQENSLFSS
YALTDPLTGIPNRRALYHELSRSLANAARYGEALYIAFIDLDGFKAINDQYGHDAGDRFL
ISMTSVLTKGLRTGDYLARTGGDEFVFFGLGSRADTADKDEDVLHHRLESLTTGRFDIGY
QSIEYPGASVGLIRAGNGERDIDGLLKRADAAMYVVKRARRSRRQF
>A0A0X8HDG1|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MSADLHRITTKRDFDRSLIEAIHEASPDGILVVDDQGMIVSHNRRLFEVFDIPLEALPGD
HGGNLSGYSEQAPLALAMDRLEAPEAFLKRTQELYDDPSMEDHCELSLKDGRTLERFSKA
LWGNDKRYLGRVWFFRDITPRKEVERKLEVLARRDPLTGVANRRHFFELSGAEVARARRY
GTSLSLAMLDLDHFKQINDRFGHSAGDRVLINFCNDVATLLRESDVLARLGGEEFVVLLP
GSDPDGAFQLAERLRGHAEKAIVEEGESRIRYTVSAGVASLTPDDASIETVMGRADDALY
AAKAAGRNCTRHEAPR
>A0A120JW18|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MTRFLCSLQGRLLAGLAATWLVIVGILMVLAWQYGKALVDEVNLDHLRDESRLIADGLTE
KVNRRLNALGRLAPNLQGMSPDELGTALDRNQALLEWFEGIMVTGPDGVVLADWPVVEGR
VGLDTSETEYFRLMSHSPWPYVSKPFVGRASGDNLVLMLVPRFDEQGAFSGVVGGMVNLT
GGGLFRWLERSWLGEEGRVSVLSASGEVLFHPGRTSRQAFNGLPSLDLALEGWEGETIAR
GIDGESTLMSYRQIRPANWVVKVSLPRSQVRAPLGDYLVTLWWAWLVLAVVLMFSMRWLV
RRMLKPLHRLEQQIAQVGAGERRYLALSTSMEELRQVAGSFNRLEHERLSALEHLRDRQA
FLDAVLGSTPIGMFVADLKGHLNYMNPALLELLGLDASCTPEEWWGRIHPDDRQGTQDMW
RHSLSTGNDFMRQLRFHHQDGVTLWVEVHASQVKGSDQPLGFVGMVKDITERRQQEALQR
WEAEHDPLTGLLNRRGFERRLEEALAEYAKTGTPSVLILFDLDHFKPINDEGGHALGDEM
LRRIAQVVAWEVRRSDHVARQGGDEFAVLLPSCTLKQAQEIAESLRRVVSEVTVVNESRV
YSITLSMGVTAFQEGDDAVETVLARADAASYKAKANGRNAVVMADPDDGSLIDSLW
>A0A6S7BJN8|diguanylate cyclase|EC 2.7.7.65|Pararobbsia alpina|TrEMBL
MRGRAGGKRVNRGEHQPLLDPLTSILNHKKMNPDSVSAKLLEALPAAVLVLRGGLMVYAN
PAAHLLLEVEMSGEYPQGLVGQPIVEFIHPLDQSHSVNRIRRSASSKTANVPVEVRLQTR
RNRVRVVLVTSVSVDLEGEPGVLVTAMEVRRDSTTGERMRRSEEHFRRLFENMQDVYYRT
DALGVVQLVGPGVRRVLGFEPHEIVGRTAEEYYPNHADRDAFKDAIRKFGEVADFPGQMV
RKDGRIIDISISSSALFDEDGAFAGVEGIYRDVTERKELERELRRLASIDSLTNILNRRA
FIERAREELGTHYEPGIEQTLLLLDIDYFKSINDQYGHATGDQVLTRFARAVGEQIWSTD
LFGRLGGEEFAILVKHTNPEQVRDLVDRVLDAVRTIRLEADGRPSRAVTVSIGAARRTSI
DHRVEHLLDRADRALYQAKHGGRDRVFWERTA
>A0A8G3JH22|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDADNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8F9KJJ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGEHIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>A0A8F9JRW3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPPRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRLPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHGLSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYADDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKATLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0M2HU43|diguanylate cyclase|EC 2.7.7.65|Microbacterium hydrocarbonoxydans|TrEMBL
MVVQDIQASDAEDLRWLRFGWLRSIRERTSTFSVVTATLLLYFGVLGVFELFEDDLPLFE
QILSGGTILLCLGTFAMVAFFGLELPMWSGLALIAAHALVSVYYLGFSDERQNAIAAFQE
LPIMAMYFSWFYGARIARTGVLAIVVVVGAATAFGQFSGPGGLLGPVNIVAAALFTWMCL
EAGIFMRHRNRLESHSDELTGTLNRRGFEAKTTLEIRRALRHNRPLSVAVLDLDKFKHVN
DEAGHAAGDYVLRAVSAHWMSLSRSTDIVGRLGGDEFAMLMPETDVDEARSLMLRLREYT
PHPWSWGVAQVRPDDTAASVLARADAAMYDDKRR
>A0A2D1QMM4|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MRRALESVYQIISSLSHSSGQGYFDTFVSEIAAAIGADFVLISGRDQAGLFFKVHAAYPA
SLDTTSLTFPVSATPGEITLQEGEAWFSDRVQQLFPHASVLQAWHIQAYAGIALKNAQGE
TIGICSVLFKRPLANMDKVMGLLRLLAPLAGRELALMFQQQPVQSQPEYHHFLHTMMSHA
PVGIGKLDLDGKILWTNPAIEKMLGYSQSELLHRTAAELNHPEDWLRSVSCYAELKRGER
TAFTQEKRYLHRDGQVLWGRVTVTLVRDEHLQPDYLMVVLENIDPLKRHAEQLKLSHRVY
DNLSEAILVCDADSRIISVNPAFEQITGYSGEEVCGQRPSMLKSGLHDQAFYADMYHALE
RVGVWRGEVWNKRKNGKLYPQQLMISTLREGGKISQYIGIFSDLSQTKLAEQKIAAQANY
DNLTGLPNRWLFGRCLTRFCERGERFALMVLDLNNFKAVNNSMDHHAGDALLREVSDRLV
SRVRTEDLVARIGGDEFAFLVPGIVNRRQAEVFAKQVIGGFARPFMLANQHLYVTATIGI
TLCPGDGVESDELLRNAEQALFAAKRQGRMLGSYCASMREEVRQRHQMQQDLAEAIKLEQ
LTMAYQPIWDNRSGRVAKLEALVRWYHPHWGQVSPADFIPLAEEAGLIQGLGALVLWQSC
RDLARLQQSGFPDLQMSINRSTLEFQTIDPEASEWLKVIHHFGLDPCDIVIEITESLLME
TSDQHRVRIDALREAGCKLAIDDFGTGYSALNYLRNFPVDLVKIDRAFVRHIPFNEQDRL
LLDGIINIVHNLGMQVVIEGVETREQLNFLCQKGCAFTQGFLLSRPLAYDDLVEYLQLND
KSMFLQIS
>A0A5C7D815|diguanylate cyclase|EC 2.7.7.65|Serratia nevei|TrEMBL
MEISAPNTFGTHKGVMLTHSLLVALATFLLALLSLSLSSEARHFTPLWFPTAAAIAVLYR
HAPRHWGLPLLASGLGIVLASFLLFGVSATPVKLAAINLLEAAVCALLLRRTLPANDPLS
DLGCWLRFVVCAVIFTPLFSALLAAGLSPTPDQTFWQSFGIWFISEAIGVLSLAPLGLTY
HRRTLAALNPYPLLLTLMGSLAFSYLALTYLPFPFTFVILPLLWAAIALPRFEAFAVCFC
TLLLITVLISLGVLHLQASAHVFGELGLYLPMLLILIPAHAMAMVMHTFRVEKQHIVESE
SRFRSALEYSAIGMALVSPEGKWLQVNQALCKLLGYTPEGLHRLTFQAITHPDDLNADLS
QLHDLLDGHISSYTMEKRYIRSDGQTVWALLAVSLVRDAEGQPLYFISQVEDISGLKRSE
AENNRLVERITLANQVGGVGIWEWVMSQENFTWDQRMFELYDLNPDQTPTLALWRTLLVP
EDRERTDRELAALLADPKPFVMEFRITTRGGKLRHIRGQGNVILDDQGQPLRMIGTNIDM
TELKILAEALHEEKERLHITLDAIGEGVISTDSHLRITFMNPVAEQMCGWPLDLAIGMPV
AGVVRLTNGKDGPEIENLTQYPRQWPADYALVLHSRDGRYFDVQQSVSPLKTLDGETMGA
VMVLQDVTASRELMKKLSYSASHDALTGLPNRTRFEKQLKAAIAAGGEPSSPHSLVFLDL
DRFKAVNDTAGHAAGDALLRDIAQLMRHQLRNSDCLARLGGDEFGLILFDCRLEQAKSLM
QQVVNQISQHPFYWEGKIYRVGASAGITRIGGDAKSSELLAQADIACYTAKHHGRGQVYL
YETRQKQLLERQHELLNPQEVQTIISEGQLRLLTRAVAPPATPLSAAFHQVKLQVMAPDD
RPLPHEAFIAAAQLYGLMPDIDRWAVTQLLVSYADDIKRKGLSLALPLATDSLLNTDFQR
FLTETVRASSLPPRALLFSVDEAVVLEHAAQCRACLRELQQLGCRLIVNGFGHNINAFDE
LGDQKIDIIRIDERFITNVHCNQMDELMVSMLNGAAHRIKAQTLAGPAHQPVTLQALRDV
GVDLADGDQVALEQPLAVLLSDGYFGIR
>A0A1V6GTV8|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin072|TrEMBL
MRAVTTRKVQVGEKRRRKDLEKRLTELEHMSCDDIGLFGEIFKSVNEFIFEHDLQGRFTG
ICPRFVGFLGYSREELLGLTARDLLLEKDREHFQSYLDRVLARGKDEGLIQLVTKIGRKR
IVEHRNTLMVNPDGTRSIRGIARDVTDVLETEQALIESEIRFRTILDSIEDGYFEVDLNG
DLTFFNDAVPSHIGYSPEELLGMNYREYMDEPNARVVFETFHSVFTTGTPTKSFDWELVK
KDGTRIFVEASVSLQRDRNGNPLGFCGIIRDISDRKRAENELAYLAYHDALTGLHNRKAF
LEKLDEAIREARRYENRRTVLYIDLDHFKRVNDDHGHEIGDRLLAQVAARLRTVLRDTDY
ISRLGGDEFTVILGGVTTPGPVKPAERILRTLGMPYEISGLTIDFVTPSIGISTYPDDGH
DAETLLKHADNAMYKAKERRNTFHVYGQETGEPQAPRIRRVR
>A0A157Q1R0|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MMSKKMNRILLRPDLRHLILWASLIIFVLALANTFIAAYRVQQSALLANTLELNRVYANK
VAQATDVFLDGARQLLGAGADELSGKSDINGQSAKLVVDRLSRVTDTFNSLVVVDRRGLV
LATIPATLRLVGTVLESDEIRRVLSSRTPMTSEPYRAVTGRWIVTISHPVFDAEGRYAGA
LFGTIYLHERNALHAVLAEHDFTDGSALYVVDKSGRILYHPDNAKIGEQVGKNPAVLVAR
AARTGSARVRDEDDIDELAGYSRVNSTGWTVIAQRPTAVALDVVQEQFGRMFLFSVPIIV
LCLAGIWWLAQFVSVPLRTLADAAGDLGSNQATDQIRGVNGWYFEVEELRGAMLRAASAV
AGRIGRLKRERASDPLTGLLNRRGADEALADTHHQHASMSVVLMDVDNFKKINDTQGHAA
GDEVLRGLANVVRAQVREDDIAARMGGEELAVFVPGVDREDGLAFAQRLRHAVEAGLAGV
TVSIGVARWPDHGSTMDAVIAQADQAMYEAKRAGKNRVHSAP
>A0A4U9TEZ7|diguanylate cyclase|EC 2.7.7.65|Staphylococcus capitis|TrEMBL
MFEAIIYNISVMVAGIYLFHRLQYSENKKMVFSKEYVTVLMTLVSLLLAAYPIPFKSEYL
VHLTFVPLLFLGRYTNMIYTLASAFIVALVDVLIFGNSIIYGITLVVIAGVVSAVGPFLK
QNDIVSLLILNFISIIILLILAFASPIYDLVEILVLIPISLIITIASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNEVSRIAEEKNHSLALLLIDIDGFKDVNDSYSHQ
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIRNYSLDQSVKLAENIRSGVEKSSFH
LPGKEVIKLSVSIGVGYLTQDDRKSQRKVFKDADDMVHVAKNEGRNKVMFNPIVKL
>A0A6N3CC89|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MFINLKRLPDRLFLYAVVCGFSIATINFVTGSLIHRISTTSSMLFPVLTISLMGFHIMIA
CFMGMKYLCDKKQLYLAPIAFAFACSALLMLGTIGSYPDWLVCAQGRVINQNDALIFYFF
RNVMMAVLFITSIVLYRLRHRTTHSGKIHGLVLLGCFILIAATLILSWIHSSNSPLLSIE
FIDNLTYTFTPLWHNRVGWVLIGTWSFTLILLISLTRLRNIFWYSGAFFCTAYIFTLLVL
LSTVNGNAHSWNQARLFETLSTLFLILVLLVDVFILYRESNERYVRSYQNSIRDPLTRLY
NRSYFYDTLNQRLTKVSASQPLSVIVCDLDRFKRINDTYGHVQGDKVIQFAASVLQNNVR
QEDIAARIGGEEFALLLVKIGANEALAIAERIRLSVSEQHEGLPERMTISMGVFTTQDAH
VAAEECVKRADTAMYEAKNTGRNRVVVWQA
>A0A1T4ZLW9|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MCEVKQNKTMIFNNDFVQINPESIHTQGRIQPHGLLLTLEEADLKILQVSQNAMKLYGIS
TTALINRPLSDFLDKQQLFQIQECLISNNFNYYNPIRLIFHIKNKKIICDGILHRHQGIV
ILELEPTQDQNVTFINFYHLVRGSVCKIQSATNFKDLTQFLAEEIRKISGFDRVMIYQFD
HDNHGVVIAEDKRQDLESFLGLHYPSLDIPEASREIYRQNWLRLLVDIAHQPVDIVPSLH
PVTQKPLDLSFSVLRAVSPCHLQYLKNMGVQATLCVSLIKRENLWGLIACHHYSSRYLSY
TIRKACEFLGQVMAVELPYREISEDYEYYREILKLVRKNLLNAPALEASFIQTLAQDQTN
LLNLVKAQGAVIRFGEDLILVGQTPPLTKVKKLMAWLSQYCHQEIFYTDCLPKLYPEAES
YHDLISGIMAISLSPNQSEYHLIWFRPEVIQTVDWAGNPQNSTEIETPGEIKLTPRRSFE
LWKETVKLKSLPWKPVEIETAQELRNSLMLVALQSSEHQLRQSRELAQVTLQSIGDAVIT
TNSRGEIESLNPVAEELTGWSLIEAKGLPLNDVFKILDSQTHNFSASPVQKVLEEGCIFD
FSDNVILKAKDGKERSIDNSAAPIRSREGEIIGAVLVFRDVTQERELTRRLSWQACHDAL
TGLINRSEFEKRVTQTLQMLSKSSNHHAIGYLDLDQFKIINDTCGHLAGDELLRQLSFLL
QSQVTERDTLARLGGDEFGLLLNNYSLDEAYQKAVHLCDIVKDFRFTWEEKVFSIGVSIG
LVEINNQTCDLATILSAADAACYAAKNQGRNRVHLYQADDQDLIQQRREIRWAAQIPQAL
EEDRFCLYYQPIVETNPTSKSPKHGEILLRLRDTSGQLVPPMAFIPAAERYDLMKSIDRW
VIRTVFSHLEKHYQSLNLTPNSSKSQDFYAINLSGASLNDNQFIKFLYQQFELYKIPPQI
ICFEITETLAIANLKKAVHLIQSFKELGCSFALDDFGSGMSSFSYLKTLPIDYLKIDGGF
VKEILTDPVAREIVESIHRIGHVMQIKTIAEFVENDAIFTEIKNIGIDYVQGYGIGKPQP
FILPMIKNSGQISQNRD
>A0A859WFE4|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MDKLMWVEKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMRSALGTPLDFAALRKAEEDYLTKRHDPIWSVEIHNRRTLPI
YGVADAFVDSDALLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
ELPKNSTQALALYSRATGAAWFTRQTQRNNPARGIVWQTFPDDESQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTLMLLISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERAIAETRLSERLK
RPVAVIQLDLDYFKSVNDHFGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TPLKEAQVIAERIRIRINSREILLGNSISLRITASLGVSGSDDTGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A0D6JJ13|diguanylate cyclase|EC 2.7.7.65|Candidatus Filomicrobium marinum|TrEMBL
MHTPSVHYIFFSTAIFFAALLMALEYDLIRNWDLKPSEQKKLQVEEIFVLASILIAELLI
FAWRRMRDRADELMRRMAAEQDAHQSARHDTLTGLPNRKLFAERAGEALSNSWNRGTDCA
VLLIDLDGFKPINDTWGHASGDAALLEVTERLKSCSPKTGMVARLGGDEFAVLCEAPLGG
TAAMSLAQGILRELEKPIGINGHNIAISATIGIAIGPANGRRAEDLIHAADLAMYEGKRS
GRGTVVMAT
>A0A533QKT3|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp|TrEMBL
MQQASASARHDPLTDVLNRRGLDEALAREIAGMRRKTEQPLSLSLLDVDNFKQINDRLGH
ATGDDALIHLVQVVRQYMRPVDTLARYGGEEFVILMPDTRLEDGMTAMRRLQRELTRNFF
LSRNEKILITFSAGVAELHPEESGEDAIRRADQAMYLAKRAGKNRVMGA
>A0A448IGG4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MEKGLRGFLLIWWRQPHEFDWTARYFRAQGLMRVHQVFIGCFSLLYGATALLTVVWAYSD
GGSVTARVLVIGIAASSCLLGLAWIFGPWPTERQSAAFAVYADLAVFAVIACYQDAFTAM
PGLALLATNGIYVVVVHGPRALLLHLVFTASVIGWMTLRVLNQDIHPTSVITIRLLTLLP
TVMFLPVIVQSYLLALRMGALDSLYDPLTRLYNRRGLDSDLAQFRGAAVGVLAVDIDKFK
AINDSHGHEAGDRVLVAVADAAREAVAAQGVRSVIARTGGEEFVVVIDGGTDVLLSTASL
LHDALAASDTSAAPTVTVSIGAASGRTDGLAVRAVVQELIERADAAMYRAKNAGGNRTVT
ADDAVSPQE
>A0A3S4RXA7|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MQRDLRHADHYEWFSGFLDARGAAVQVRLAVAGTALSMAVALLVLLTGSGGPQTQPYLGM
TWAAVGGGVAGAALWLARWPTRAQSGAFAAVTTISITLACLAYPDPLAALLGCIAFTTIG
AYLAFFHSSRAVLGFAAVAAAVAAVPAFEMVLAGRIALAAVDYFLVVQANIAMPLAIFAL
LRALRGDLARADLDPLTGLLNRRAFHTQILAMMARYPQEDGYLLVALIDLDDFKSVNDTH
GHIAGDQALVAVADALRATTPPTAVVGRSGGEEFLIADVTSSRDAAQRYQEVCDAIAVSG
MAVTSSVGTALAPLDALSQHSDDDLVDLVDQLIAAADRAMYRAKRNGGNQCHHHGLWLTP
EPRRDV
>A0A0M7G3S0|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MDAKTAVRGVECVDGPGRLGTGLVTPVIRRELSLDPILAELSASLQAAKSVEQLTRPLLE
MLGAVTGLESTYLTSIDPQADRQQVRYARNAGTLQIPEGLSVPWSDTLCKRALDEGRMAT
SDVGACWPDSEAARQLGIQTYVSAPIRTDDGLLLGTLCGASASQRPIAPQAESILRLFSN
VIASFLEREQLVAQLRDANARLLAFALTDPLTGLPNRRALYEELDRLRGRALREGGSVLV
GVVDLDGFKGINDTHGHQQGDVFLQEIARRLAMTLRASDMVGRLGGDEFVLIGPGPALAR
GDAAPGHEAQRGDAEEAARSLEDRAAAATVGRYQLGEVTLPYEGASVGVVALDPRGLSAE
EAVRLADARMYDIKRARKAARTIH
>A0A7U1KRQ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3GV97|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MIRFRQLVAGRSQYLFLSLLWLLFFLAPNISFAQQQFVGQWYEVSQNWRFPDPPFKTIDA
PVLTGGHFVFRSSFEITDADETIVIDFKNASVLGHFHHYISDSTGNVVAEARGGIESDAK
NTFFLRHGREFRLPAGQYELTTELVSTYFIAEPQPYWDSLAHYRHAIKWGTVITLVSMGI
LISLGVYYAILAYVRRRITETMYTIFIWMNVVFNGTSLLITPDLFNIHWFYLAGAPILLS
NFAYLLFAKHLLQIRASTHPKLNTLAKLFLTGMAVLLVVAIFNKHLILECARYGVGLMML
YGLIAALVRAFEGYKIAYFYLVAIAAFFIIGSFAISSKDLEGIYTIYIEHIGLLAVTVEV
LLIGLVLGYQFAEIYREKENNLSLIQHSLQIAHHDALTGLPNRYALDLTLEKLPSNGMIT
MLDMDNLKTYNDTYGHHKGDEMLQMFATILSSKLDTLGVLHRMGGDEFAITSESLSYAER
IKEVIAETISYMQLNGFEKAGVSYGSAYMIETMNVDDLRMLADQRMYQHKRRHNDPQWA
>A0A446CWN3|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MVLIVALSILTAMIAFINALVVAQIVQKDQLIARSLEANRAYAAKLAETVDLYVESIQRQ
LEVSASRLPAMLASQEALDAEALRVAKQSDGVVAAFVADSANRIIAFESLAPELTEKPAE
LSRVEIDQREVAGHVSAAYLSAKGFPTVLFSEPVRDAKGEYLGLVGAAIFLKRDNELDRL
ISVHFHHDGSYVYVVDSHGKILVHRDKSRIGTSESGNVVVDAVGRGEAGAMAVTNTRGKR
FFAGYAPMRSGNWGVVVQTPEDVILEPQQDLLWRSLLYSVPAAVLTLLLIYVLARWIAQP
LSRLAQAMLLRGDEGRAALQGVSPWYFEAQQLREAVGVTLAQHQRQITELNTETLTDPMT
RLLNRRGVEDEVERLKASRQPFAVLALDIDHFKRVNDTFGHAAGDKVLIVLGDLMRASIR
AGDLPCRVGGEEFLVLMPAGDVGIARRVAERIRSTVERTDMPEGVGRITISIGVARWPED
SGDTDAVMKFADQALYGAKNAGRNRVVVYPF
>A0A1E3GTC7|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MKPRMVNRTFFRTLILVGFLATHSVSAEVLLSQAEQDFLAEKQFIKLCTDPDWLPYEGID
ENHEFTGIMSDFYALWSDKITTPIELVHSNSWQQSLQLIRNGECDILSSAMDVPSRRDWL
NVTTPYIFYPLAIATQPDHEFVVKFEQVLDRDFVMVEGYAGIEMLRDRYPDIKIEAVTSS
REGLKLVETGQVYGFIDTVPTINFQMLRWGISHLKISGVLDIQYAMSVGVSVREPQLLEI
FNKVIADTTDLERQRVLKNWLSLDYKQPDDKALFWLLFSAVVLIMMVLIYRYTKIHHHNR
KLRQLNTRLEHISQYDHLTGLANRYALHQRFNVEMDLASQTLQTFSLILLDLDFFKDIND
TYGHDVGDNVIKEFAVLLQSMVRENDLVGRWGGEEFLILCSQTSKNGAFQLAEHLRLQVQ
TMGFSVDRQITASFGLSEYRQGETIGDTIKRADDALYLAKNNGRNQIVMADSDLDESTTK
H
>A0A2S8DPD4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRQEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8E2THL7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALADVNSFYASCEKVFRPDLRGKPVVVLSNNDGCVIARSAEAKRLGIKMGTPWFQLKE
AQFPEKLYVFSSNYELYASLSNRVVALLEELSPRVEQYSIDECFLDARGISHCMDLEDFG
RQLRGHVLSGTGLTIGVGFGATKTLAKSAQWASKEWPQFSGVLALSPENPRRTAKLLSLQ
PVEEIWGVGNRIAKKLHVMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISLEE
APPPKQQIVCSRSFGQRITTYGEMRQAVCQYAERAAEKLRGERQYCRHISTFIKTSPFAV
NEPYYGNVATEKLNTPTRDTRDIIAAAVRSLDRIWLDGHRYAKAGIMLNDFSPNGVAQLN
LFDDVQPRPHSDALMKVLDGINHSGLGKVWFAGRGIAPDWQMKREMLSPAYTTRWKELPV
ARF
>A0A8H9AEN5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A823BCP0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
VAKNLSSDNIKYSLNIIQYSLNRHLSTWNIVYTQIISVFWLVLLISSCISIRNYSKIWLC
IILISIVSVCNNLILLYFIDKPHPAWYMTKFLELISMIYIISTLMYYVFRKLNHANYMAI
HDPLTNTYNRRYFIDSLKNISKHHSFSVIMLDIDNFKSINDKWGHHMGDQVIVMVTRIIK
KSIRKDDILGRLGGEEFGIIIKGNSQKLLLSIAERIRKNIEEQCSEKLLSHGPEQITVSI
GCFTSKENNHSPSEMLVNADKALYQAKRTGKNKVIIHSK
>A0A5X8YY86|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kisarawe|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSTEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A823AY87|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHETPAVAHDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
SLSPEHGSDSATIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWHGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQ
ALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRT
>A0A6G2C038|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSLLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A483PMM7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALRLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A486URL9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWELS
DLARLYVVKPSPETLTQYQQLQQTDKSIEQRLAGLKDNGASREELALLQDGLRIADELQD
EQQAALTHVARGDAPAAIAVLYGKAYETELERMQTQIDRFRQMLEHRAAIAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLSPAGETTSFAPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAHAGQSLCVPLIAQGEAIGLLSFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTR
>A0A8B4T0N1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLGVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTHDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A3D1C093|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFALADVNSFYASCEAVFRPDLRGKPICVLSNNDGNIIARNASAKKYGIKMGIPWFQLKN
MHFPEKIYIFSSNYELYASLSNRTLSLIEEMAIRAERYSIDEVFLSLEGLGSCIGYEDYG
RQLREHVYRGTGLTIGVGAGMSKTLAKSAQWASKEWPQFGGVLALTRDNPRRTEKLLSLQ
PVGEVWGVGSRIAKKLNTMGITTALQLAQANPAFIRRNFSVVLERTVRELNGESCIALED
APPAKQQIVCSRSFGERVTTYEAMRQAVCQHAERAAEKLRGERQFCRQIAVFIKTSPFSA
TPYYGNVASEKIHIPTHDTRDIIATAISALDRIWVDGYRYAKAGVMLNDFTPTGVSQLNL
FDDIQPRERSEELMKVLDGINHSGLGKIWFAGRGIAPEWQMKREMLSPAYTTRWSDIPCA
SI
>A0A377UY86|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAMMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
AEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLECYSVVCRRCKTA
KTH
>A0A332M733|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHHLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSPERRRSRDGAA
>A0A2X3ELP7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MAEALGLALANQRLRSALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMID
IDHFKTINDRYGHEAGDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGRTSA
PARSNTQVRNMTLRDGLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELAAQGL
SALAA
>A0A332DD39|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEAVRSARGRSHV
>A0A377UTX5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MVGDRAIKHVADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAF
NVGGDTQIPITASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A377WM93|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQIMTRLFRCWICRAMSWC
HSPAP
>A0A1V6E034|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin110|TrEMBL
MKLDASILKDFFLDSSLSDFFKEIDIFYIDFISHTAQSCTTLRSLGYEDPDLLKVMENFP
VHESDRERANLQLQRIWSGQIETFIDAFRLASKDGSSYRWLRFTLKVLLRNSEKRPKIVV
GHVVDLDDLITSQEEIRERLVEIDTMRELFTAINKSLDFSETFSRTIDQLRRIIPFDRAC
AESLEDGRLVVVAGYGYNDSDLSGLVFPAHGVENPAVRAIEERRIVICNDVQHSFPGFIN
ATEEFTAMSWLGIPLIYEKKVIGLLTLDNKELNAYSDQHVRIASELSEYIAIALEHARRH
QLVTRQAMTDKLTGLANRYGLETHGLEVFQKAIEQEHSIGVLIIDIDHFKQINDTYGHAY
GDVVLQTIALTIRGQIRTRDYAIRYGGEEFVVLLPELGTREALIVAERLRNKIAQIKMED
NKKMPTVSIGIYAAIPGTLDILHEFIRKADMALYAAKEAGRNRSRVWSISPEFYGEK
>A0A7Z7X662|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQQPAVQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A5B9P7K1|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MRTSLSNDFQTASREVLDYLHKQLGFHLWMVTRVESDDWIVLSANDHGYNVESGQIFKWT
DSFCSRMVEGNGPRIAPCSDSIPAYATAPIGKQVSIGAYVGVPLEREDGSLFGTLCAIDP
EPVSDQIIDQLPMVEMMAMLLTKILENELKAQEHHRKAERAMTDAITDQLTGLYNRRGWD
QLLAAESDRCRRYGHPVCMFSIDVDDLKKVNDTEGHARGDELIQLAAKVLDETTRKSDIV
ARLGGDEFGILAVECNNLGAVSLKRRLLENFKSAGVSASIGMSMWNLSQDFLDSFKEADA
NMYKSKHARRLNGGPPRQKHSRTFLR
>A0A8G1GTQ5|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MTKLSNPTEIARETLKQLAMRRMLPSPDHYEAIYHEIAQTPELERLHPGLKELIDALSKL
PQQSQVVTRQIDQIRSAINQEKWAEIPESIFRIVSSQTDQAELSKGWSELIRDLILQWDL
RNPSYTPSRKKEALDRVLLNFKQDSAVLNEKLNGLINAWAETGIGSVSDIDVSSALGESS
PSQSESSQAKEVEWREWRDAFTQALEFGLATKLLHNIDLQSETLAIAQEAKAVDSIATME
KWVPRLRKFWLKLELENDNEQRLCDGLMGLLRLLTDNMSAIVVDDEWVRGQIAVVQHIMA
QPLDMRVIYDAEVGLKEVLFKQSQVKHSLVEAQAVLKNMLTSFIDRLGYMSESTDKYHDK
INTYAEKIDSANDLTSIRHVMEDLLQDTRSMQLDVRRSRDDLFEARQQADEAHHRVMELE
AELSKLSDKVREDQLTGALNRRGLEEAYEVETSRAMRTSSPLAIALLDIDNFKKLNDSQG
HAAGDTALIHLVKVVKDLVRPTDTVARYGGEEFVVLMPETDIAGAIQVMQRVQRELTKRF
FMHNNEKMLITFSAGVTLYRAGEARDASIERADQAMYHAKKSGKNRVITLD
>A0A8G1GQV3|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MAKPLRTKRFIYMAWLAQLVLSFSLYSLFWWQNQHILHTQKHNQIAQQIAQLQAQADTVL
ESFAAFQSRQAFPQDKSIRPFAELLLSRNPHIYCLQTVQRITHAEVAGLESTMRAAGYRG
FKVHDFDYEKTRKTTALKVRDVHFPIVFMAPLPREAEDVLGLDVNAVHFLSPQLQNSGNQ
VKAWSTGPFRLIEGEIAYGITIPVYQLGGQKPDASWPLYAGLVIKANSLMPQLQDLAPGW
QVSMDYIGSVTAQQKQLFKITSPGELFWIAKLLPTIEMVSVIASDSQPFELRTRQQLSWR
SWLGMVPLMMLSFLLLVLLLALRWQHSERLRRITVQRHKNQLHRWATQDRLTRCANRQNF
DQRMTLASQSGVPFTLAYLDLNYFKPINDQYGHLAGDAVLVEVAQRLRRSVRSQDLVARW
GGDEFAILVVGLSDNERCAALRQALLDALAPPFIWQSQSLTLSASIGIASYPAEADSVSE
LLQLADQRMYRHKTAMRNREIEI
>A0A8G1GQ99|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MSLIRELYLGVSVMEKLAIGQALQRQGHPKRAMQAYLDGLAQVQQSAGDEAAYWLAIADL
EHEAEQFTTALSLHQRALSLARCEKQQCAARLGLAADLWVLGEQSTALALQQKALTFDGL
HEDPVLLEESARLYRLQQQWRPALQQLRSAAALNDGDGIVLHLAILQTYLQLDTNEGLAD
AVMLAKQSLESSHLHHQESLLLALAQCCERLANYSEAVQFYQAALSVQTTQKATKKTPRR
LLGVELKLQQTISGIEIELLRHSNAQQIEQVRRLESATYRDALTGLHNLRYLQARWDELL
TCHSLCLIHMGVDQSTHLRDVMGDEVANDSALRIANVLRRCCPEEGVLVAANNNEFRLVL
LKTSVSEVNVLIQTIQAEIALLDCSQLPEALTLSVGCTAFKEGDKADVLQLRADLALYLA
MRKGAGAIVWEGEA
>A0A517VEE2|diguanylate cyclase|EC 2.7.7.65|Gimesia algae|TrEMBL
MGSSKILRQLISLSEDFEEYSLESDSSDMIDQVISRKHLRKLLSALQARDASTLCHSRRV
AFLAKGIATNLGWEGIHLKRLEVAALLHDIGKIGVPDHIIFKPGKLTSDEIELMSHYHNI
GLDVLQACHTDHEVLTILSQTRYHFSGATNGYQFIGSEVNQGARILAIADAYDSLATDQV
YRTGKKHEDIMSILMEAAGTQFDGNIVCALSRWEQNEKQAFHDALQEVNRLFQPKDFTER
EALEANLINNIFSYLFQIESLYDGFYIVNSDFQFVLISPGLEKLADLRAIDMLGESWTSS
SLPLTNTEGTNLTSAECSMNRVIANGKPMTTEFMLERPGGRLINIEVQSVPMFGDDGRLI
GVTEIFRDLSRSLKRPKEYNDLKLAASLDALTSVANRGELETQLAIMLSRIQKEQNPEPL
SLIFIDADHFKDINDSYGHSTGDEVLVELARLFQHETYSGELVGRYGGEEFVILCPETAL
EHAVKKAERLRLAVSNLKMENQSNIRVTASFGVAQYEPGDSLESLFHRADSALYQAKETG
RNKVRALTCEQMKSGEVIPDEVPEKPDSEGMRFESTFNALISSDFIVYKLGGFVNDNHAR
LTEVSTNRAVMRLGKAGLLPFWGKTDDRKPVEIEVVFGSSTKKSNSNRRQTSSQVEIATR
ITPLGWIKQPEVFQQRAGRVFRLLKDYFAAE
>A0A3M2RD55|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MDPRERRSSPRQPIKLAAQIDVGSGESLPCQIADFCAEGLYIRYSGQTSLKLGRVFEQAE
PKDVVVRFRGLDSNVHHELHVRPARRIERAMGVSFVRSNPEAIEALIRLCGSGDNQSRSS
LQAPSDRVQFVLHQCARVITQFIEPLMDACFVNTADALKTAAQKASSDQLANEYMDAAGQ
LEGRQRILWHHMARSLESPLKPEQKGAPGALLSVVDKDEFEDWLAVKVMVTRADTLYRGD
LLELKLRLDHLGISNRTGHHNPLGPALVCEAFHHALMQLKVSRDVEKVCLKVFEQAVIRQ
LAPLYRELNNILIRHGVLPDLDLTKYLSEQAAEQVTPKTPESKPKRKKEDEATDPSATRP
EEKTGSKASGEFRGYSKYAHNAFATVRNLLSSLKMSRSAEDVPASETFEPGARPLTSSEL
SQELQELQIQAADLNEPDVPLKERVVAKVKGSGENARLSEDSEDALDVVDRFFRSVTESP
KLSRFAQDKMRQLQVPVLKVVMRDPSFFEDHSSPVRSVMNRLAQIGVKGARPNPVVQRKV
DELVQRIATDFDQDTVIFDEAVEELDTLIERQNLAYRRNVERVTAAAQGSQKVAESKAAV
AAALDAKLGGRKVPKAVVSLLDGGWRDLLSLTWIRQGEEGQLWQDYLAVIDSLMAYAESP
GNSSNLPELLRLIQDGLASISSNRTPSSQIRDELKQLMVRQPGEPLDLVEMPKAQSDKPA
KSDADEREIKSLQRWINRAQQLQVGDWFKDQSKSDDLHYIRLVWVADNFSRFVFVNHQGM
RVVELDVTVLARKMREGALIPDSQYEKPLVDESIDRMVRNVYDQLSWVSTHDDLTHLLNR
REFERLLEHQLTQHEDTHTLLHLDLKGFRLLSDVAGHKAADETLKQVADILCKHADDGMP
VSRVEGTEFAMLVPDDKADAVARSLVSSIEAAEYRFDGKTYELTANVGIVPTVPAVTSAE
RWLRTSEQVLSVARRGGAGHVSVYNQDSEDQARQEQIAARVANLGDPADDRMLLRCQKII
PLHPEARMSAAQYEILISMYDDSGELVTGRDLVRMAERYDRMQAVDRWVVGHMLDWLQEK
KPDARDVGGICINLSGHSLNDQALLEFIYEKLSEKDAPIERLWFELTEASAIHDIQAVAR
FIGEMKELGCRFCLGNFGTGPNSYDFMRTLPIDLIKIDSAFTHQLATNATDQAMVKSMVD
MAHFMDREVVATQVETREVLDKLTQLGVDYAQGFVIEKPKLLNSLI
>W6KG21|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MSPSDDFNQVAETAWAAVEHMAKLKVEPSPNNFSVWYHYHVGDMPDLRRTLDILLDNNQD
FTPDRNADIHRKFFTTDEERASVRSASDELEAQISKVLTYMAEMGGSAKDYGETLQSHSE
QISQAGGPDDLGSAITSILEATREMEAQNEALEKQLAASGQQVDQLRTDLDKMRHEALTD
GLTGIPNRKVFDAALRTAATEAMEEGGELTLLMIDIDHFKRFNDTYGHQIGDQVLKVLAQ
VLTSSIKGQDTAARYGGEEFGIILPATSLIGAKKVGEAVCDKIRNKSLVNRKTGKKMGRL
SVSIGVSLFQYGEPLGQLVERADACLYAAKGRGRDMVIGEDELSPDELQVAK
>Q32G36|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MIKKTMEIDVILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAISH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6B8NFQ2|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MVKNETLQTRQSDAILDIRQQKQVLKFIAAITLIFFVPLGIKNLLIGETMLGAVLLAFEI
TLLLEIAAIIYNKVGLFGHFIPLALLVTSIIMAVNIFGTLATYWVFPIIISIVFLLPART
ATIANIVVCLGCTIAVLPHQELSETSRYAFSLLATAVIVHVVVKAVRQLQTDLRYLLVRD
PMTGAYNRHQLQSSLENIRQLYTTSSIALIDIDKFKTINDLYGHDVGDQVITQVVKIIDA
ETEHSTMLFRLGGDEFLLLFPQADQYAVESSMEAINRAVKESDYPQEAKVTLSSGVAESQ
PFETIEDWVKRADIALYQSKSLGRDRVSLFSQPDRVDNDNQSTYQRASR
>A0A4U9HYJ3|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MLIALSRTLETCCRKDDYVFRWGGEEFVLLLPRTSLDAAMQIAETLRVAIARIAIPGLPR
FTVSIGVARHNPDESIDDLFKRVDDALYRAKNDGRNKVLAA
>A0A142Y351|diguanylate cyclase|EC 2.7.7.65|Pirellula sp. SH-Sr6A|TrEMBL
MSLLSTRISNTFAMPLPAGANCKGLLVKIHPMEWMEKPSEIPSAGLIIGRDDACDLKLLD
DSVSRRHARLRYEGPMICVDDLDSTNGVFVNEQRVHGSKSLEAGDRIRFGNQIFKLVTEE
GFELQYHEVIYKMMTTDALTQVYNRRFFLDSLERELQQSQRGLQSFALLLLDLDRFKSIN
DQHGHLAGDRVLCEFARRARSVLRSGEILARYGGEEFALLCVPADEEQAAAVGERIRAAV
AATPVDFESIEIPVTVSIGVACYHSVDTCDSATLIQQADEQLYRAKENGRDQVCVRSAAP
SPVRFQTSIQESI
>A0A8G2E8E8|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MTNWAYGITVCLTITSGIAMLMASNAETAERQVVQQRQIFDQLTETVETESWELSDLARA
YVINKNPDVLQEYRQQARSLTTIEHRLEKLKDRGATPQELMLLREGLQIADELQDEQQAA
LASIERGADSEALTLLYGKPYEQELERVQTQIDHFRLMLEGRAASAIAQATEKSHTWRTL
SEIMVALTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPQFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFDDVIKVAELFAPNIAPA
IPGRLYVLETNPWQLRCVAQWLSPPDEPEVFYPDNCWAVRRGLSHPPVNGEPDIACTHLP
DACIHQSLCVPLVAQGEAIGLLSFRNVTPATAPSRAYLELMAEALGLALANQRLRSALLE
KALFDSLTGLRNRHHLDDALHTQINLAVQNHAPLSCLMIDIDHFKTINDRYGHEAGDLVI
KSVAVIVQRAVRDKGMAFRYGGEEFLVLLAGANEETARACAEEIYDSVRSLTLRDGLTEI
GQVDVSIGIASFPQHTQSDSLLRAADAALYRAKEQGRSRIVSFGMLKSD
>A0A8G1ZYH7|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MKTKKRSSASSNILRYIWGSALATIFLTTILSFWLLSGSWETWKSAYNNVIQFDIFYRVL
QVSNDLAGERAFVNELILSSPEEKESRWQVLVAHRDITDRDMQKIPKNLLFPALMSEMMQ
QLDHSRRIANGFRTEVLSDPKLADQAIHDMVVATDFYHKALFKRTNEFLLLQPSALGPIL
RALALGELRDAAGRLGPQVLIPLATHTPIPQANREGLIRGIERINTAWWLLQTQGDEVAW
LPHFQRTLENTRRDFEHQGIALINRLSAESDSGKPYSVSAEQFAVAYHASLGSFDNLLNT
YMTGVKEHYTAVEHRALKNFLLRLVVLGLVYALTIALIFYIRSRVLRPIVRLNELAAALI
AGKQLHVQIDDDTAEEVQGLFSSLGTLGKKLREDARISRQYQRQSEEDPLTHLFNRRAFS
TRADALLSQSSEALPAWLVMLDVDRFKSINDNWGHPMGDEVLVALAKTLNRLSRPEDVVG
RLGGEEFAVLFLAASSDEVASYTARIQQEIRKLTFHTTGDITFKITASFGVSKGWQCPLP
ELMSRADSELYHAKNSGRDRICGLS
>A0A1C3JP89|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MSSRSAAKINQYFRQTIPMMVKNNVPITPPYYTLWYSYTSGDIPELSTRIDDIVQRLGQC
DRYMCDVLLEEFVVDAAEDTLAQVQSSINQVVKSLHASTESAMSHADHLNQSMSADIEKL
SQEAIQSNTHSAYKLVSIARRFIDKTEDYRTQLEQQNAEIQALKAKVAETEKQLFIDGLT
DINNRRKFNDDIALYTASADKTCLVMVDIDHFKPFNDEYGHLLGDKIIQTVAKTLEQSCI
QIPGAQAYRFGGEEFAILLPNANLKAAIQFANDVRERISRLNLKNKKTGQSIRPITTSVG
VAQFQPGESLEALLERADQYLYAAKHAGRNCVRAAVA
>A0A1C3JQ93|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MSIPFTSAFHHMPTPAFIAQIDSGEIVAANESLENLYLNVGAARQTTWQALMNDSESNLA
SIVHKVQRGEVERLSAKLEVGDRFITAEITLTELDDRHVLGYISHTEHLDFSVAENTLLK
FALTESSAGIWMWEVEDDTISCSQSIASLLGSSLESTPHSSQAWRERIHKDDLPKMVRTV
EEHINHKQRYYEAEYRIRRANDEFIWVRERGRTYSQGPQGEVLKIIGFIEDISPQKALEE
HLRAQATFDELTGLLNRGAALTHFTKQLGLARRQYTPLTMAKIDLDARGLLADMPLEKRN
TAIHTTARYIYKKIREADILARVAHDKLLLLLPNTSLKDAQKLINDFLLPREEEQKVLEF
SDSSHLNLCVGLATFPEDGETIEELAQSANSAVEKGRTTGVSISIAE
>A0A011P6D0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MSAWQAFLRKHWMQRSWPAGKAFAWLVSLFGLAFAAQIFWLAGDQRQVLESSARLLNSTV
PSTLEQFRLARNIEQLRLDGERVFSGRTPVARQQALFIVSLLSSHPAMLADRRTAALASE
VETFLVQAAREGMSEQRYAEWDTLSNRLSLLADDFSIEGANLATDDLQLMATIMLHSQFK
LALVLALVAVFLGGFLFLIHRHLIRPLQKMDKALNELRSGSALTPFSRASMAEIRAVEGA
IGQLRDVMHENQKARQELHVLATTDSLTGMFNRRHFLALAEEEIKRAHRYARPICVGMAD
LDHFKDINDRYGHAVGDRVLQSISDLFGHTLRQSDWVSRYGGEEFAFMFTETTIEEAHRL
AERLRQRTADNWIDLGDGSGLQMTLSLGLAEASKGSLEAALGRADAALYTAKKQGRNRVV
IAGEATATPRKAVHESSDDLDLPVDER
>A0A080LVD5|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MFKHDHLAIMHSSRRVSRRLHRRPALHAMPSAQPSDFLQAAVGRAQHTHIHRFATHQREA
AALALLAAELRIGDLERALSEARAAAHTDALTGALNRHGFAEAYQREAARAHRKHSPLAL
ALIDLDDFKRLNDALGHQVGDEALVHLVKVLRTALRPSDILCRFGGEEFVLLLPETALSQ
AATAISRFQRQLAAQAIPGKDIVLTFSAGVVVQENGESLEHSILRADAATYAAKRAGKNC
VVTG
>A0A080LX67|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MAPQALIVVLSLASDEQTARQAVQRGASDYLVKGHVDGHWLPRALRYLIERQATHDELRS
SEARFRAMSDASPLGIFVSDAQGGCIYTNAAYHKISGLSFDETLGTRWSRAIHPDDRQRV
LAEWGEAVRGLAPFQTEFRFLQYDQSIVWTRVNSGAMSDGMAPHGRVETVEDITERKTAE
FVLQAAEDRLFEERERAQVTLNSIGDAVLCTDLAGNVSYLNLVAEAMTGWSYQEALGRPL
AEVFRIIDGNTRAPAASPAERAIRLNRTVELAADCLLVRRDGFESAIEDSAAPIHNRDGR
VAGAVLVFHDVSESRAMALKMAHLAQHDFLTGLPNRVLLTERLAQAIGLAQRRHKQVALV
FLDLDYFKNINDSLGHAIGDQVLQSAAARLTAAVRASDTVCRQGGDEFVILLAEIEQPLD
AALVAEKLLEAFAVPHLIGKHELHVTLSIGISVYPDDGSNVDNVLQNADTAMYHAKASGR
NNYQFFRSDMNTRAVRRQFLESGLRRALKQGEFRLHYQP
>A0A4U3C5L0|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. 15WGF|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRAALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLERASGLEAGRDSLTRL
LNRKFLSVVLNREIEIARHSEKCFALLMVDVDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVASATE
>A0A655Q3W5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTDQTRTSPLVNRLLKMISLCALGYLLIILAIIIPRGIQSVEQQKQELEEKLALSLSNSA
AIALYVNNYDIASEVMDALLLHQEINAVKLASVDGIVFERTTMPTTYKEQNYWSDANRYR
LDSPVDGNLIGYLMIHEDHQVIRQQAINQILDQIAVVLIQFLVTFIALIWIVRRLVGKPL
TDLSQALSEVRPDHDRKVAVAAEDHHNEIGLVAKSINEFIDASHQALLRERELRQQIERW
ESYYRTIAEQDTLTGLKNRLGCEKFVLRKQRASTTMVLLLIDLDGFKQVNDTLGHAAGDE
VLREIAKRFYALAQTHFSDFVVGRLGGDEFAIYIPLDEFVAESIERFAAQLIESSSEPIA
LGQQSAQVGCSIGISHMNSLHIDLEKLLLQADKAMYWVKYRGKHGYHIYRMGEEILPLPS
AKELKQDQFR
>A0A655UWR8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTGLLNRRGMESFLKGKRHSQYLAIAVLDIDDFKQINDAYGHDMGDRVICYIGEQIENHI
RSSDAVARFGGEEFVVYVTAKEKEQITRIMQRIFDAVCRESPLILEPGFTISGGIEVVES
TTDRSFEDLFKAADEKLYVAKTSGKNQLVY
>A0A656ATR0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVYGLRFTHYTRLLEQRMRFCFPLMEQKIEVSSTSRMLIMTRKKFSWILVTLIIFGFFVT
SLVSYKVAHDTLEEQINKDSLPLTSDNIYSEIQQDLIRPIFISSLMAQDTFVREWTLAGE
QDPERIIRYLREIQRQYQTISSFYISDRTGHYYHYTGILKQVSESNPNDAWFYRVKNSAP
DKNFEVNIDIDTANSQQTVVFVNYKVFDFENRFLGVIGVGLSSDAVSALVEKYQKRYNRH
IYFINELGEVTLHGSHHPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWV
DEFQWYIIVEQKDEFNHDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRYNRHIYFI
NELGEVTLHGSHHPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWVDEFQ
WYIIVEQKDEFNHDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRYNRHIYFINELG
EVTLHGSHHPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWVDEFQWYII
VEQKDEFNHDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRYNRHIYFINELGEVTL
HGSHHPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWVDEFQWYIIVEQK
DEFNHDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRYNRHIYFINELGEVTLHGSH
HPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWVDEFQWYIIVEQKDEFN
HDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRXVFEELVDDAISLANKESHPLSLA
VIDLDHFKQVNDNYGHPAGDLVLQRVVALCQRHIAQVGTLCRWGGEEFVVLLPHMTQQEA
YQRMESIRAEIAMHASQPQVTVSIGVVQYQQNESLLHLFNRADQAMYTAKSEGRNKVVGL
>A0A8G1J5C5|diguanylate cyclase|EC 2.7.7.65|Glycomyces sp. TRM65418|TrEMBL
MSLRSRLTTAFLVVVLGPVLVGAVFVAAVMSHLADSRGEALADSAVTMVDSTLGTICERI
QASAAAVALNYRSGGEANAAEMAQLVVDRSVVDGVVFSSIAAAGREGGTDIGVEAPEGSW
VDCGETAAYAGADPIVALGAQAEVRNTDGSTAAFSAFRVVDQEFLGRLARVADADIILQD
SRSDPLEAGGADAGRWDYSDSFLPLSIGTVATDVTPMYWTLAAMVTASAVCAVGLAAWLA
RSTTRPLAELSAAAERVSEGDLNVRVPVHGRDEVAQLALTFNRMTAQTQAYVQALTASRD
QMRGQLGRLGQTLTATLDLDRILEVILDTAMVTAGAEAGVIMLVDVDDADQLRERAGEGD
LGLDQPASIRLGEGIVGAIAAGGVPAHGRIVDGKFEDRVRADTEPDARTIAAVPFRGRQP
VDMLGGRPEADYGAPRTDAGVLGVLVLYNRVAGEDFEPGDVDTLRTFAGQASVAVENVLL
HRQAERLSLTDPLTGLWNYRFMQTSLRREAERCRRYQRPSALLAIDLDRFKDVNDTYGHP
VGDQVLIELARRITAQIREVDLAFRHGGEEFMVLLPETDAVGASVVAERLGRAVNVRGFK
VNDASGGRELNVTVSIGVAVLGEHADTATGVLAAADEALYAAKAAGRDTWRVAV
>A0A8G1LZK1|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MIDSEELNPRPQILIVDDSRIVRATVRKHLSAHFDLFEAADGEAGWKLLLAEPTINLLIS
DLTMPELDGLGLLARVRSSGDAHLHYLPVIIISGEEDEATKLRCVECGANDFINKSTDRT
EMLARVQANLELAAARQELAAARGMQVHSANDQLTGVASSYLLNLQLEQALAFALRHHSQ
VSVLLLEVNNFQLLTDKLGRRVCDQMLAMLAKLLESTLRKEDTLAHLTGALFAIISPATP
LTEAKIVAERLRLRVANARINYREQVLRVTASIAVANSWHDDEHSCERILQIAQDRLYAT
PMENHVFMPELVGEAHTPLIAEALVMLHKGMLTELRPHLRALLKNLQPLLAQANQDLALG
WDLSQIDAAENPEP
>A0A0H3I3C3|diguanylate cyclase|EC 2.7.7.65|Pectobacterium parmentieri|TrEMBL
MNELRNVDEQRDNGEQDYNQVITSEWMQLITTTSQKSFNLLQTLAAQKASDFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGSHLADLINYQRKIGQIHARIGIPVD
LVERGARRLKWQLYEDIAQAADDKALCFDAMRYASISMDIAIEIMNKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIATIITETDDYIRNYSNTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKSVNDTYGHTA
GDSILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHTIHL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A8B3KLP0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A656B2R5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLSLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLQLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8B3KHI1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A5I4ZZT8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Vitkin|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A822W9G8|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MYFTLIMIIIGIFFLLGGAIVVWPLIKKASYYHYQWIANLVLICFFIGSFLFVIVYTLLI
NEFFTNYFYATLFLLGGFYVFWMSYLSSKTIEKIKTMDNLKLEYEKIRYNAEHDKLTGCF
NRHYLMEILDNRFRKIKLNTGQLTVMFVDLDGFKKINDEYGHDFGDQILQRFGQLLKQQL
REEDIIARYGGDEFVVLVENIPLTKAKSIGQKIIQTTSRITKEKLPNHSSLGCSVGITQL
TKNSLSINSVLKKADDACYKAKKNHGNTIWVDDNMTSSFLD
>A0A0M2WTF5|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MFTSRSLSPAFYYLFFSGEREQQQRFFKELHFISIAILTFGLACWLVTFSLTLPRASLDH
AQAVLGVTGMLVGLLLTVYAKSLQAIIASGTISVLFIAFSFRVLMLGTEDPAFWVLPLGV
MITLTTAPIFSGIAYYLGVSLCVWAILGLGQFPVHAGQADQHWPVLAVTISVIIGLALNI
YFLVLRIHNYRSQRELATMAYKDGLTGLNNRRMFTQGARTLQRTARTPAYFLMIDIDDFK
QINDVYGHDVGDEVLKKIADVIARLSGEHLCGRLGGEEFAVIYLGEKSAACAFAAQLVDS
VEAAFVPERKVSVSIGVAELLKEVDLSHSYRRADESLYLAKKNGKNRYVLNAA
>A0A7H0MFG7|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. SMBL-WEM22|TrEMBL
MKKHYQHVLVTTPHPVLRLLSLGLLSFLFTLFSLELIRFGTIIAPLWFPTAIMTVAFYRH
AGKMWPGIALACALGNVAATVALFSPSFVDLRYTLVNIIEAVAGAILLRKLLPSYNPLKN
LADWIRLAIGSVLIPPLIGGVLICLLVPTENLLRTFIIWVVSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLTLTLLLSWLALHYLPWPFTAVIVLLMWSAVRLPRMEAFLVYL
ATVMVASLVLAIDPGVVTSSKSSVMMNAPWLPFLMILLPVHVMTMVMYAFRTERKHIIES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRLMTFQQLTWPEDLARDM
AQLAQLVRGDIPSYSMEKRYYTRNGDLVWGLLAVSVVRHANGSPLYFIAQVEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWELEPDIISWDKRMFEMYEVPAHLKPTWQLWYERIV
PEDRPETERVIRDALASRIAFKLEFRIAVKDGIRHIRSLANRVLNKQGEVERLLGVSMDM
TEVKQLNEALYQEKERLHITLDSIGEAVLCTDVAMKVTFMNPVAEKMSGWSQESAIGQPL
LKVLHITFGDSGPVLENIHSGDMSRTDIEQDVVLHCRAGGSFDIHYTITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFEAHLKRLLSTVQEFHQRHALVFID
LDRFKAVNDTAGHAAGDTLLREISTLMLSLLRSTDILARLGGDEFGLLLPECNVESARYI
AGRMIEAINDYHFSWEGREHRIGASAGITIIDEYNHQASEVMSQADIACYASKHSGRGRV
TVYEPKQDLMQQERSMMSLEEQWRIIKENHLLMIARGVASPRVPEACNFWLLSLRLWTSE
GEVMEEHAFRASLHEPELIRALDQRVFHEFFHKHAAAITAKGLGVALPLSVHGLASSNLV
DELLLMLESGPMPGRLLHLVIPADALVREGHNRIENLRRLRQAGCRIILSRVGHDLEVFE
RITPHMADYLLLEPEMVSNVHGNLMDEMMVTIIQGHAQRLGLKSIAGPTHQPMIMDTLSG
IGIDLIYGDTISQAHPLDLMLNTSYFAIN
>A0A738CM27|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 30:1,z28:z6|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5P9ITV1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MQSNSCGHQWIIRLTQQQSERALDAALIDILSQVFADNNFALYMNKQFTSQGRIRCSYSG
GSAAILNDEQAQQLVAKIDAERMRISGSQGQYVYFPIYHLGAVIGFVQSSSDFALTHDSP
FVITNILNIYANQLYLLYRSRLDPLTELLNRQTFDSQVMDIINGDGFAERRDNELERQWY
LAMFDIDHFKRVNDTYGHVIGDEVIILVARILKQSFRSEDYVFRYGGEEFAVLLLCDNKD
QAMQVLERLRATVADFTFPQVKRLTISTGFCAFDDTSMVPELVHKADLALYSAKNNGRNQ
VVDFHSLNIPDNPKGAGDDDLDDDMLELF
>A0A5P9J2J1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MSGYPYKSLHDLAIEDVEWMRWQKLVNTVAALFNSPVAFINQASTKGIEVLVASELPTTH
YSPGGSASKEVNVYCHHVVQSNTPMYVKDTSTTDQWNDNPEYTKDNYVSYLGYPIQWPDG
RSFGTLCVMDTAPTDYKQHLFDVFELMRDVINSDLAHIYKENELKVESRLDPLTGIYNRR
GFEEAFDKFTALSCRLNRNAQLLFIDLNNFKSINDTLGHEAGDQVLQRFAHILKSCTRES
DLLCRWGGDEFVVMLNSDDQVAQKEFIQRINDKQNSECDNLGAPEICFSAGGAEIAPSQN
ANLRDFIHIADQQMYSCKDKAS
>A0A2T0B4N2|diguanylate cyclase|EC 2.7.7.65|Clostridium luticellarii|TrEMBL
MDKETLIKLLRKKDDMFKKLCIEKEKLNYYASTDAMTGVLNRRSGLELLDKELTFSKINN
KNLVVCFVDVDGLKTINDNFGHQEGDRLLMNTAEILKDSIRKTDFVIRMGGDEFLVVFPG
ATIEEVHKILNRINLRLEESNKNNNSYSFSLSYGFCEYKKETECEMTLSDLIKKADLEMY
KKKLQKKKEL
>A0A2R5FDG9|diguanylate cyclase|EC 2.7.7.65|Novimethylophilus kurashikiensis|TrEMBL
MANTQTPIEIARQTLKNLALSKVPPTPDNFRRAYEEISGIKSEDPVQVLIRLLKEAGRGR
PKFAKLSTQLQQASSASNLADIEALLRQLLPSGKDGEPGHWGELLRDLIRELEISRPGMS
ISKKKDGLERLLTNFGADVNVLEEKILALVASWKSGGKAAEPLVEESEPVAAAAAQPTTT
GAPLPSSSLAGQWRDLLVKTLEFGLLSQLKYLPELARNAQQLLEQAKAAATDKQVTKLAE
DFKAFWYKLEMNSDAQFRLHEELLQVMRLLVDNMSELVVDDQWLRGQTQMLREIIEKPLD
IEVLYDAESSLKELIFKQGKLKHGLIEARETLKQMAASFVERLAEMTENTGEFHDKIGGY
QQRLSKTEDIAELNVILDSIMQDTRAMQLDALRARDHLQASQKEVRDAEQRIEQLTTELM
QLSEVAHQDFLTGTLNRRGMEEAFMREFSRAERASQPISIALLDVDHFKKLNDSLGHDAG
DVALIHLAKVVKSTLRPTDVLARYGGEEFVIILPQTDQDGAIAIMSRVQRELTKNFFLHN
NQKVLITFSAGVAERQGQEQPEDVIKRADLALYEAKHAGRNRVIGAAA
>A0A8G0JNM3|diguanylate cyclase|EC 2.7.7.65|Lysobacter sp. CJ11|TrEMBL
MLQGVFHGMRVELARLLDRAFPPALPDGLQREYYRTNYRFARLPLILLGPFGALATLALL
ALNDNFRPRMWQVLMHPAVLTAIVFTLVAWGAMIRSRRITNFGRACLAFMLGVYVLLGVI
CYEYPALTPSVILQMMIWQLTIAPLVVRTGTFVATLTISITAPLVFMTFSGASPATWLSL
ICYLIPICAVATIVYRACNRLRRETYLSNINMRESAFTDSLTGMLTRRRFMELASRSMRF
SEGAKTPVCACFIDLDDFKQINDRYGHAFGDRVLSEAAMCIRAIGGHIREADTTLQARHI
ISGRVGGEEFALMMFGHSMAEAMEIADEVLARVRRIDVDGVRVSTSIGVACARTDESMRG
LLHRADMALLDAKSQGKDRIVASPGGHAD
>A0A8B4WNW0|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKLLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A7Z8DQ45|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A661GUI0|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium|TrEMBL
MADFPPELELLVDQFDTAVGAHLDLMRRVLRCAVLRVSPGDDVLSPQAHTLCSFGSWFGD
NKVHFADRNFQAIDRIESVHQAMHDAIRSMCSDVLANKPGQSDYLDAFEQAQSELIERLA
DFKTQLLATSVRQDPLTGLPLRYSLEDDFTQALKTCDRNKMLLYVVMIDVDHFKAVNDNY
GHPVGDVALRHLADTLKTMVRSNEHLYRYGGEEFLLLMQAESHESMKIPAQRLLEVVRNM
RVPIPDGEPLALTVTLGLARVKKGETIEQVVERADNALYAGKAAGRDRYVFADD
>A0A7Z1J3C7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMASNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A380B7N4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
CKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYCFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2Y5AQ96|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A3S4ILV7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A381C5K8|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MFDNAIQRVISRFKNPQKVVNLCFIVVFIFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHNIDNLLFYRNSMLYALQSPISTDKTRKTLADFDSLRTQPYWQLRLDLNRSLPM
NGVSDEFVNNSPLLDRDEQTIHTELSSALELSYFMRLSHQTQTLAQRMFYASRSGFFLTS
TPPSNDPQIVALYYRLVAQPYFSSQSPENNPKRELKWTHTFNPDMSSGQIITAAIPLDYN
GRWYGVLALDYPIDSLHNFLRQAHNNEQHEGTVLLYDNELNPIATSAQSLPRHPLFTAPQ
LARIASVVTAAKQGAQGELRMDSRFITWAKLNNYDGLLIKVHTLEEGVQGEFGRISVVLS
VLWLLSTLMLFVSWVVIRHLVSNMFSLQQTLTWRANYDTLTRLYNRGAFFEVASKLSQEC
QQQGQPFSVIQMDLDLFKSINDRYGHSSGDKVLAHAAAMLSDAFRQGDVAGRVGGEEFCI
VLPDTSLEEATKVAERIRVRINSKELLLKQGSTVRISASFGVSSAFEFNDYDFERLQSYA
DHRLYKAKQDGRNRVCNTD
>A0A0D8HPG5|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MDAVENSTSAAALRHSLLIGLCVFVACLIGTFSRLPGTLAVFWPANALLLGLLVRSPRSA
TVPTWFCAATAYISADLVTGGSVESALWLGASNIIGVVGGFYAFRWVCAEDRRLSSIRSV
GYFVSATMVAAALTGCVGGAANVALFGGTWPDGWILWFSGNLVNYMTIVPLVLTFPSLRP
EDRDPEAVSRILRLSVIPAALLALCILLQWVIGGAGAIAFAMPALVTAALLTNVFVTSLM
TAISTVCTLVLTADGHLGTAVEGLSAVSVSVRIGLALLATAPLAVACVIYERRRALAALT
EAVMLDDLTGALRRDEFMRKSIGAVGSLQSGLPVSVLMMDLDHFKKVNDTLGHRTGDTVL
VAFADQVRRHLDDTALFARLGGEEFVVLLIDTDLDEATQIAEIIRVAQQEQSRTTLGELG
PTVSIGVACSPSGDADVNSMIDCADEALYLAKKFDRNCTVSLTARS
>A0A6N3HK27|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLLASDADTAERQAIEQRQRFDELTENIETDAWVQS
DLARLYVVKKDPQILKEYNQSENSLKHIELKLEKLQDAGASDDELALLHEGLKIVDELQD
EQQMALANTARGEDAQAIALLYGASYEQELERAQNQIDHFRQILDKRVITSVREATKKSK
ALRTASELMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVNDVINVAELFAP
NIAPGIPGRLYVLDRDPWQMRCVAQWLAPVGDETMFHPDECWAVRRGQSHPPVNGEPDIA
CYHLQEETANSALCVPLIAQGEAIGLLSFQNINADNAPSRPYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLHTQMAQAMRNDEPVSCLMIDIDHFKSINDRFGHEA
GDLVIKSVALIVQRAGHDSGLAFRFGGEEFLVLLPGAGEAEAHACAQKIYDGVRELSLRY
GLSEIGPVDVSIGIASYPEHAQSDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A379ADB0|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MRRGVSKEIGGISAWYFEAAQVKRALLTGIGLVQDKIGRLSSEAQTDPLTQLLNRRGLNA
VLEYYRTLRQPFSVLALDIDHFKNVNDSWGHDVGDRVIQQVASTLACQRPSV
>A0A4R8R3D0|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MGRLKIAIGLLCMSMVVLGMVVQFHPLGPRGLWPRSIQAATWISAFFVGVCWMVCPWPGR
RWAIAFVFWADAATAIAAAMCSSPASRLGATNHMALIGIFAAFVLGWRVLVGHCVFASIA
ITAITLWNVHADAATLFGQYIYNAPAFSNVVLLPIIIQTVIEGGRRALWGTAFEAHRDPL
TGLLNRRGVQSAIDYTLGSGRQPTAVMAVAVLDIDRFKQLNDNYGHGAGDSTLKAVADAL
LANIRRNDLAARVGGDEFMVVAFLHGARDVEQAVQRVRCLRPKVGDLKVSLSVGVAWAFM
GEPDFNFDSLARQADLRLYENKRQRSGSAETLRLASSEE
>A0A212KJ25|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfovibrio sp|TrEMBL
MLGFAVIIGTTVNLLRDRYLRKTLQKLNDTLRVQAQHDSLTGLLNRRMFDEMAEAWFAQT
LRLGVPFSLVLFDIDHFKRLNDAFGHQAGDHVLREIARYVSIRLSRRGDRVFRIGGEEFA
VLASASEERQIVSLMEKIRKTVEDMRLQHPDGADKVVTISLGGLLVHDCCNMSFDEAFRR
ADEALYSAKAQGRNRSILADSCSEEENTDCLIRPHS
>A0A1C3JJ52|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MRFSLFFIVMCWSVFASAQAKDVLVIHSYHQGFFWTDDFHKGLSDELDRDGLSYRVVYLD
TKRTQNAEYLERIYQLYRTKLSHEEFAAVVVSDNNALNLMKRLAPELNGTPVIFGGINNF
SPQMIEGLHATGITEDIDMASNIELINRLQSTVKKVYVVTDHSVTGEAIRAQVDLFLHKR
PEFSGLVEQYTPDSYQELMTFAQRADLTKSLLFWAYYRDINGRVSSKEDWRQLNKKTQMP
LYIVHDLRLGFGAIGGVIHSGETQGRDTGRVLLNVLANPDKPLPQVVAGAPEIKLDYQQI
SRWDLGAENEASVTFLNKPKSFLVRYRDEIRTIGLLFLVMSCVIATLVYYLNRLKKSERA
SRKSQLLLESIFDQSLQFMGIIDKGGVLLSSNSKLHELLYNQGYKLGTPLQQHQHWESSA
REVLAEYFIAKSEHPALRFEAEVWCRDRGAMVLDISLKPMPGSEDEDIQFLFEARDVTSR
KLAENKLFQREANLKLYYDKQPVMMITLDGNNRIQQVNQFVEELLGYPLDQLLGHRPREF
YVDENAMIPRHILLQPQHKIRGVWRRDIEYRHADGSKIWIRENIRPLVESDQLLIVGEDI
TETHELSEKLEYQARYDLLTDTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLN
DTAGHEAGDAAILFSAKLLEDVLPYNAVLARMGGDEFAVLMKDCTERDAVNVCRSIISMM
SENPFLWDDIRLNLTCSIGIRLIDHTAASPQMVHAQADAACHAAKEEGRNRYHLYHQDDE
DLRRRHLEMECVNLVHEALANDRLELFAQRILGLDENSEKMHFEILVRIKNIKGEYISPG
IFMPASERYNIAHLIDRQVVSQTLGWLEQRPEVIEELGMCSINLSGHSMGNRDFVEFLID
SLSDSSIPCHKICLEITETAAMSNMKQAIKFFTRIKELGCMIALDDFGSGLSSFGYLKKL
PVDIVKIDGLFVRDIDVNEMDHVMVRSINDLAKQMGKHTVAEFVENTQIIDKLIELGVNY
AQGYIIGRPKPLAELVEELRQERETESLV
>A0A011NQX3|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MIDPKNPLEVARETFRLLSLRKLLPTPANYQACYNEVAKLPNVAGFPEAPMRQLVAALGR
LNPAAGERHLAALEAAIGKRSWQGVQEALVAFTAGNKPTGAPADRSEASPAKCDGTPALL
VSLLPPLVQLIENLLPSLCHDDDSLLAQGKQLLQTLEAQTGDGRELLTRLAAFSQRISLI
AEEQGEVRLILLKLLQLIVDNIAVLSVDERSVRGQIDTLARAVLPPLTLRRLDDVERRLQ
DVIGRQRAAKERTLAAQEAMRAMLAAFIDQIATMNQLSTDFQNNLEESALQIVDVQTIED
LTPLLQRVLNATRSMATETAAARDQLGELQTMVLDTNAELTRLHEELQQASASARHDPLT
DVLNRRGLDEALAREIAGMRRKTEQPLSLSLLDVDNFKQINDRLGHATGDEALVHLVQIV
RQYMRPVDTLARYGGEEFVILMPDTPLDDGMATMRRLQRELTRNFFLAGNEKVLITFSAG
VAELLPEESGEDAIRRADQAMYLAKRAGKNRVMGA
>A0A518BKE0|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pla133|TrEMBL
MAQDLFSLTQIRHLMRVEFSRAQRYSYPLGGLVIRVDGIEKVRVGHGFEAADDVVAQVTD
MLVARTRACDHLGRLVDDRLVAVLPHTDSSGAQALGARLVQAAHELEVTVAGQKLPVTVS
VGSTCFEDSNTLFFDALVDAADAAFEQAVAAGGDRVVHVSPAEVA
>A0A0T9TAW8|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYGAEEIIGQSFELF
YTPEDLAGQLPTKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDADNNLQGFVHV
TRDLTDKWQRENALRKSEELFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKATAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIAQHFGCFFLPEDIAAGLPEKLLKTAASAGRIEREGWLVRKDMTRFWAVTVI
TVVHDHNGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDC
EGRVVLMNPKAEEMTGRSQNESCGLPIEEVFILWSPLQDKNQLVAFNQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLTHAIGQLGESEQHILCYVDLDYFKEVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCKNAPATEILEQVVADIAAIQFHWHGQSYTFTASLGAVPV
IRQIETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A0T9SUS2|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MLIASLDALNILSTPVWVAVPKTQELLFANKEARKIAGDCPLPLMRHGRFSAHAQQQLDA
YLPALAGDDHIVEIWTIQTAENIFPLSCRLSLTQLENYGDVIVFEGLYISERVLAQPPMG
QLSSKPYQQNELGFYEQLFNTNTAPMLLIDPSREGQIVDANQAATRFYGYSRDELCMKHT
WEINTMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCVI
HDITEQKRLEEALEHAALRDPLTDLGNRRQFFPLVEHAHTQSQRYGHNFSLILLDVDHFK
LINDQLGHNKGDEVLILLARTLESIIRESDIVFRWGGEEFAILLPLTNLEGALQLAESIR
ETIQMICQPNLPQLTVSIGVAQHQLGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A4P8JN93|diguanylate cyclase|EC 2.7.7.65|Alcaligenes faecalis|TrEMBL
MSQPNIEEAAQDWHGLLQKVPLAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHD
QVHKRLHRSLRSWLVQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFLFESSTISSEQAWECYRYIQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNLIDTELMPAFEQGDAKGQVLRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTHGHDAGDRILRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMNITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYV
>A0A624B334|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMLSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1A8TUF0|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MEMDPHIFPCGLMVSDFQEQKILQLNAYIENEFGFAKESLIGQPITALFTKASILFLEHY
FYPMLLQDGKVSELQVMLLSAKKEPVPVTINATLSQQGKIHWALFSAINRDQLYQELINT
RDKLEDKTKALTITSATDELTGLLNRREATKRANEMIQQTKRADLMLSFILLDIDYFKRV
NDTFGHQKGDKILIEMSKVLVNTVRSCDIVARWGGEEFLIVLYNTPIDKANTFCQRLHDR
INQIAIGRDTLHVSIGMTGYPIDKQALNLDEIIWQADEALYDAKERGRNQTRLFKESLLL
DKR
>A0A4P7TT16|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIVSTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVVLTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>B2U4J8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEA
ILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPA
NPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAR
ELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLP
NKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRM
ILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDL
TAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQP
QVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQ
ERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAIL
RPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLA
QSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A4P7TSJ0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5a (strain M90T)|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSKRLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A855M8H9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp. ECNIH14|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLHISASLGVSSADETCNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>A0A105T2W0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. TAD18|TrEMBL
MSRSSAACVSHFLPSLLLLIAGLAAAYVKDLNVFFTSLFNVLPTLVLLLGGAYCAVYRRQ
RELFLMLTVYIAYFLLDTQTDYYRDNGVVRPDAAVIFHVCSLLLPLLYSVYAAWEERTHL
FQDLVARFAVLLAIGSVALGLEQSYPQALLNWLAEIRWPALHGRWMSLIQLSYPVFFIGF
VLLGWQYWRNPRPLHAAQLVGLVGLFWMLPQTFILPFTLNIMCSQVMLMIAAAVAHEAYQ
MAFRDELTGLPGRRALNERLQRLGRNYVLAMSDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKVSGGGRAYRYGGEEFALVFAGKTLDECMPHLDELREAIAVYNIHLRNQENRPQDDQQG
RQRRAGTRATSVSVTVSIGVAERMPEQRTAEEVLKAADKALYSAKSAGRNCVVAYGQTRR
GAVRTTEIPA
>A0A6N0LBR1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 10FS3-1|TrEMBL
MNNENMAMLAEQWEQICQNYSSDALLQALQFVQEHSVILVDEFYKNMLLEKESAQFLTDK
LVQQRLHTTLIQWLSESFSVPVNKDYMQAVQRQAMVGHVHARIGIPAWLIMRGVREIQYM
VFQLLGLNPSAHAFTTCSYIIEVMGFATEIMCRSYEAKTVANQEIKHSYRVFSAMQDVAV
QKDKQRSALLDWENDLMFKVFSGTGPFRHPMLSKSEFGLWFIHKAAYAFAESDQVDLVIK
RIYQVDEVNKAVGECTENTNMLGLIQHIRDINREIQHLVDQLFQVADYIEAGNDSLTQLL
NRRYLNTIISREISYSRQNQTPLSLLAIDADFFKNINDKFGHAAGDVALKFIAEALQRYS
QGSDYAFRLGGEEFLLLLVDADEKRTRHIAESIRQYVENSLINDGQGQCFKLTVSIGCVL
FDGHPDYQKFLDAADAALYMAKNTGRNLVYMAKSPSCGQIKQQRRA
>A0A238DNU2|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MGSYLHSRLRRLWLGVAVCAALFMAWNAWRAWQDIRNQSQERLRAFAAEYAIEWRSTLRA
REDAMQRLGRRLLVRPESAQQQLDTYLLERPGVEGVALADAQGRYVARSGALPPPPLQDA
QLTPPTRAAYAACLRDKTFCLGPPIPDKRAAGSWMALEYLPLSAVPGGAQMPSPGGAGRT
LAGRAFPQQWLVLAQASVSVFPRALGLLQAPGEGMAFVVLRNDGLLQLRFPPPPHLPYGQ
PQSGIMLEAIRGQPQATSGMFSGVASSANRHLVGAYVRVPDYPFVIGADLPTRSLLQRWA
GQLAGTLLLFLGLFAAGSWLFASALRQLGRTERGREQALDGLRRQRDELDVTLSSIGDAV
IATDARGRISRMNPEAVRLTGWPASEALGQPIEQVFRIAVEGEDPPAPCPVARALATGRV
VVLGNHTELSTRDGRVLAIEDSAAPITRHDGEARGAVLVFHDVSDQRERQRRSERLKSLY
AALAELGEIVQQHARQGDELALFHAACEALAASSLFNAAWIGRPDAAGVFQVLASAGNGS
HGLGQIELRLDDPQPALAVRAWLAGELRVHNDFPADPINLPRRDFVVAHRWHSIAAVPLL
RAGRPEVILVVTSPARGLFQDDVRELITRVARLLDHALDEMASHRALQQVRQREQWLALH
DTLTHLPNRNMLESALQQAIARADVNGTLLALAYLDLDGFKSINDVYGHLVGDQVLRGVA
ERLKTQLPAGALALRMGGDEFVIILEGSKELAELEPVCRSFLEHLRGPMQVGNPPLSLQV
DTSCGITIYPYDRETPDTLLRHADMALYAHKSRRGPQRSAYRLYDPAMASASFSTPDRRA
ELRRKIDTGDLVLHYQPVLDRASGRIHHVEALARLRQDSDLLQPDAFLRELGPMELTLLG
TRVLQQALADLAAWVRQGLHIGISVNVAPQELLATDFSAQVLAEIARHPELEPGMLSLEI
LETEEVLGENVVLAQLSALRAEGVRIGMDDVGSAYASLLRLKTLPVDVLKIDQAFVRDLP
VHPRDRLFLDAILALGHALGMRTVIEGVETQAHLDLLWQSSADGLQGFAISPPMRPEDIP
AFVTSFRMPPRIARDGPAFKQRLC
>M1ZFA5|diguanylate cyclase|EC 2.7.7.65|[Clostridium] ultunense Esp|TrEMBL
MKGKQALLQKVIMEKNKQFDNIIKYSMAGDIKYLEKIEEFYREINDLDMELKDGMFANIL
EDFDACISGSREITVSNILNLYGKLYSVVENIDGELSNGVYKKCKSNQVEISSKKSIEKI
LIIDDDILFLKMIEENLEKRGYNTILCSNPFEAIKCLNEENISLVVLDMILPGIDGFKMT
KIIRDIDPILPIIIISSKNDLETKINVLKIGADDYITKPINMEEFYARIDRTLDRTTNYN
ALSIKDGLTGVYTKEYFWERAKEKMALYNRNKETFSIAFVDIDDFKTVNDNLGHLVGDKI
LKCFARILKNTLRSTDLIFRFGGDEFIIIFPETREMEAKLVLERFNRTKRCSKCGNEQCI
TVTNVNFSAGITEIKSAEDTVEKMIGRADKALYDAKGNGGNGIFIYEEKISYGYF
>A0A222P350|diguanylate cyclase|EC 2.7.7.65|Legionella clemsonensis|TrEMBL
MVFPAIMIVVGIVFLIGGAYLIKSVLQQTSHYRWQWLVYLVFIGAFILSYSASIFYGLLV
DPHCLNYFYGSVFLLGATYVYLSCRLMTKTIQKMEVMDDLKNRYELLRHHVKYDSLTGCH
NRETLFEMLNTRFQQIKSSDGWVIVLFIDMDKFKAVNDRYGHDVGDNTLAAFGQLLRQRL
RKDDIVARYGGDEFIAVMEHISLDEAKKIAENLITVAKQSFKKGILSKLNLGCSIGITQM
NPHSASVNSVIKEADLACYAAKQRKINGSVCVYNPMLATRNDTIDLGIHQIAE
>A0A5A4S5X4|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFAPDTRMQPWQLFSTRLGIAAMLISPVIVASSVEAINMLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSTQQGYLLAEKIRHGVESQAFGWGHNPI
HLTISMGLETREVGQARITELFNQLLLAADDEMVKAKQTGRNRICMPTLTESAP
>A0A379YYQ9|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MHLPAFQTAHLRLAIILGVFGLVLNLFPIPLFANVQLILGNVAVVIVAILLGPWYALITA
LFTATGLMIVWSSPHVYLLFLLEALWLGLARRRDIQILYASVSYWVLLGIPLLAIYVAVI
AKMPASHIPFTAIKQAVNGMIYAAIGELCVVAIPSLWHFKGKLTNLNRRTFSSQLSYLFT
LIITVSLLVSSLAFNHFFIDKQQVLINRNLDDTATHLSHATDNYLAYNTQVISSTAKFLS
LSNADINEWQALLSSVHDSNQGFKTMLLANEQGNLLAASPMANIVKLDSLSDISSVSDRE
YFIQAFYNHKTFVSPAFIGRGFGNDVIVAISAPIFSQNDPNQARGIVEGSLDLRYFSSID
KQNLHHEQQSILLTDENNNLIYASEGLGLAPLTPLSFSKGSEIYRARLQLMNLHNLDSNT
PEYIYAQHKLNNGWQLYVLEPFVPLLKLAERQYVNTVILLFCSLVGAFFITKAISKLLTE
PLSLLAQHFGPAKQEKASDEKFEHDLLDKSTPKEIYSLYESLASNQQALLEHQQELEQKV
QQRTQDLEAANVKLKDLAERDPLTNLYNRRYTEHQFPLIQQMCERGQDAMTLAIMDLDHF
KQINDTYGHLGGDECLKVVAELLTSLFKRDIDLISRYGGEEFLLILPMCNALKVEAHLNE
FKQQLADTVIINPQDNRSFNVTASIGAVIANATYSDSLEHWLKQADNNLYLVKEQGRDRV
VCSLIV
>A0A1J5Q8V3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSVTGAGGGLCYQAIYQQDRPCLDCHAAGLVDAGGQPNGKVMRSERFNEAKDAWCQLQEG
AITLPDGRCALFSIASDIGALKDAQNRLSEAHAELALKNQLLESLSVTDRLTGLFNRRKL
DELLANECERAARTDATLSLMMVDIDHFKNVNDTFGHPVGDQILVSMAELLRHGVRKVDT
VARWGGEEFMILCPATPLAGACAVAENIRASIEATDFPLVGHKTVCFGVAQYHPDETCQS
LVERADAALYRAKNEGRNCVRLG
>A0A1J5R7G5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MVSCINTVFFTHLPLSESLQPSGIELYMRLLVSLLIVVIGYMSSRLAQRRIEADFLKNDA
QLHHIIETSLDGFWIIDQQGGFLEVNDAYCLMIGYQREELLNMNIIDVEAMESPEVAIRH
IEQIIKTGADRFETKHRRKDGYVLDIEVSASYGQDGQFYCFLHDVTRRKRSEVELKDSEF
RWKFAIEGTGDGVWDWDIETNQAKYSTRWKEMLGYSESDTFPTCQEWLRRIHPDDQAQVT
EMMRAYLAGEAPAYVVEYRLRCKDDHYKWLLGRGMVVQYGENGKPLRMIGTHVDLTERKA
AEEELYLQKEYLKAIFDSEPECVNVLAPDGALLDINAAGLRMLQVDNVEDAQKAGLLSFI
ERSHQPAFLALHKSVMEGNSGVLEFPVNGKRGGKRWLEIHATPLRDKQGQVVSFLGVTRN
ITEHKLFQYELEQQARFDYLTGVNTRGYFMQQAEMELARAIRYGHNLSLFMLDIDYFKKI
NDSHGHKAGDMVLKELAVVCKQILREVDIIGRIGGEEFAILLPETNLDEGAEVAERLRSA
IEQAEVQVESGLSLRFKVSIGLTSILSMDESLDVLLVQADKALYVAKDSGRNQVHVAM
>A0A0M6XY46|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MFRLKKKTSEATHPGLEAPEAGRRITVWIYSLAALVIFLSTASLTFIAHMAWGEADRRAL
EAEQMRLTNTLKDIHRQVARNQVTMAQWDDTFNALQAPLDREFIEDELIGDLWEDFNLDR
TFVVMPDGTLIAQAIRDDVLIENRQLPAENLVRKLAEQTAAAFRKRHDGSNSVFAEWYMP
QSALLETSQSAFAQIDGSRAFLSAIPVLPDEGHVRLEGDYPAILVNAVYIDQDWLTGLNE
QLGYRDFRFFPGEPERKHPTNYLVQAADGSTFGYFKWDHSKPGREIWIMALPLIVLLASI
IAIVAFALATKISRLSASLEESERKNRHFARHDALTGLPNRHHFSDCLTFSLDGLPDRGF
AIFACDLDRFKPVNDTYGHEAGDQVICTVADRMRLLVGKDGVVSRIGGDEFIVLFTKHTD
RDRLAALAEEIRRSIAEPIDIGGGQQVDIGVSIGIASAPESGTSEKDLIRMADMALYRAK
DKGRNAYEFAGPHSLEAAKARKQMDLQAIPASR
>A0A1W1H4L2|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MATEQDKDQYILELKSRAEKLQSQKDILMKELTAAEETLEATVNMYARYFPAIIDYIKDT
NTSFVISLKELGNAIKNGDSPSTIENLLSQVQTSMLKESPPTNSKGKSSIFSSFFKNPEC
AADADAELDIYLESIKTGYINLTNSMKETLDSTYGTKLNQIATKFQNTQDFETIRQLQDE
LFSLIQQYIYNIGSDREKMVSFVKEIVKRILQIEAGMTNSFMHNNATAKSNEEFENLLNT
EIGELKTNIDVSERLQDLKNHVSQTLSSIETALKEKTAKDKAVKILSEKNRNEFQAGFSK
LKKELDQAIKHSRDLETKLNQDPLTKVYNRRAYHKRISDEMERFLRYKTIFSILVLDIDF
FKKVNDTYGHAIGDKCLQEITRRTKPLLRKNDMLARYGGEEFVIVMPETAADGALAVAEK
IRQTIEKIEFIYKKDTIKMTVSIGVSEVTDGDKNHEKVFERADAALYRAKNEGRNRVCVE
SR
>A0A1J5QBY8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MRTSIKALAHPFDDARALADQTIGLLVDHRTAPHPVNFTVAYAYFGGASADLVDALDRQL
RQGATLDEAVLHELFDQYIATERISGLSAAGSGLHVLLTRLAEHLGEAGADVAAFCDQLD
HAAGALRAAPGVDALQALVAGLIDSTLTLRRRQEQLTVQIKSSQVETELLREELEEHRRA
ALIDPLTGLLNRRAMEARFDELLSAPRAAVFSVLMIDIDDFKSINDLHGHALGDAVIRNV
AAAIRKCIRGADPAVRYGGEEFLVILPDTPPGGAARVAESIRVAVASLRLVRKRDNFQLR
AFTVSIGVTTSRDGDAMDAILHRADQALYRSKQSGKNRVSVVADA
>A0A1J5SC20|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTQQRIEGYPVLIIGAGRGGCALLEMFMEDSLVKVIAIADTNADAPGLALARAHGIPTYS
DAVQALLACRDYSDCIVYNLSHDDSIAMEVSKIFGDKRVASGPEVKLFWQMVTNLKQVKG
ELEKSQNQLQSIIRNVMDAIVMIDEHGTILGFNPAAEQIFGYTQQDVQGKNVKLLMPEPG
RSEHDGHIKSYLHTGRSRVLNVRGREVIAVRKNGDEFPMELSLSEMTLAGMRYFIGIARD
ITERKLAEQKIAHLAHYDFLTDLPNRALFLNGLEHSALLAKRNGGKVAVLFLDLDGFKQI
NDTLGHDAGDLLLQGVSGRLKAAIRASDTVARVGGDEFLFVLNNIGSHESASLAANKIIA
LLAEPFDLKGQLCRVGASIGISLFPDDSTDLEALIKQADEAMYLAKQSGKNTCKHYRELQ
KIRPDCR
>A0A1J5TR94|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKHSKIEDFAADWQQLHQHIPEATKKLISDTVNRHAPDLATLFYEHMLADKEAKPYISHD
VVSQRLHASMQGWLRELFSLKQQDPKEIYKYQCHVGVVHARIQMPISLVLRGTRLLKQAI
TGYLVGTELDRAGLVQATRFVSEVMELSMSAMTDSYIVNVGKSVRTDESYRMFALGQNML
AERERQRAALSEWAQHILLHLLGDEAAGVPEMRHSEFGLWLQHKASIIFHEAPELERIRV
CVDRLERKLLPSLIEKRRSGGDARAAMRQVEADIGEVKFLLTGLFDRFIEVESGRDSLTR
LLNRRYLPTILMRELALARNSDVPFAILLLDIDHFKNINDTHGHDGGDLVLQQAADLVTS
SVRVGDFIFRYGGEELLIVLVEIGKEQALQVAETIRERFAAEPMRVGDGKMMPVTVSIGV
AAYNGHPDYERIVKDADDALYRAKNNGRNRCELAN
>A0A7W8KH24|diguanylate cyclase|EC 2.7.7.65|Deinococcus metalli|TrEMBL
MLTTLFLNLCILTSCAFMLGFTYRRWPVQGRGPWFWARSAGLAATGLLLMQFPATVVPGV
FADLRAVPVVFTVLHSGPVAGLAVALPLMLYRLHLGGIGAPIMVLSTISMLLVGTVVRRL
DSMPGFEVSWRRRVTRSLLTLLPNGVGLLLLPNGQTLFAQTYLPLLLLSLAGYVVVMMIV
DSRLTTLRLLSTLEGQALLDPLTDVANRRQFEHDLPGLTVGDAVVMVDIDHFKALNDTYG
HPMGDAALREVAQRLRGELRGGDRAYRYGGEEFAVILRDVGATSLPVVAERLRAAVGRDP
LSSVDVPVTVSVGAALMVTGDPRQVVGRADQALYQAKAAGRNCTVMSVGADFQQSGQPGS
RSEHSPASSAAQA
>A0A1J5RUP4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MYASRDDRLTTHFSDNFSGYTGSGSFLVKDRDEWIKITRQDFAQVQGRIRIEMLDLSLQD
VSDDVVVATAFFHIHLPEVNQMLSREVARLVLIFRLEGNEWKIVHSSISIPYHPAQDGEV
YPLKSLQVQNSILTALVEERTQALLASEALYRQLTEDTLDVIWKTDSNLRITYISPADER
LRGFKADEMIGHHVFEMFTDEGVARIKEAIQQRAASEQSGAQVGFASFEAEHRCKDGRLI
WGEVLSKPDRDAQGVIVGYHGITREITRRKLLEDQVRELAFHDSLTKLANRRLLVDRLTQ
TIFSSKRTQYYSSLVFLDLDNFKSLNDTHGHAAGDLLLIEVASRLKACVREIDTVARFGG
DEFVLLLGNLSADKQEAILLATIIAEKIHISLSAPYYVKVASADMTCATIEHYGSASIGV
AVFNGSDASSDEVIEWADSAMYQAKEDGRNLIRFHGA
>A0A0M6XYS7|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MAERMHATDTQNTSVPSEKAVDLGYYSPAKRPPPSFPAGYVLHQVTVQPLSSCPFQVCLL
DVGATGELPTCDFHRIRDTTLIIACSSGELAAKTQLTLLEGGVDDVVDADDTDLLLLALK
RAELVIARQGGLFRKCRDLAIERDNLQSAIDNLPSPIFFKNRAGIYSGCNKAFEAFIGLP
ASKVNGASVYDVAPAELAKVYEAADEELMQQGGVQIYEADVCYADGERRTVTFHKAVTRD
RVSGEVNGLAGSMLDITERKRLEEQLKWAAERDALTEAYNRRRFFELAAAAKERAQKTSA
SLSILVLDVDHFKLINDRYGHACGDAALNHLVGLLKRELQEPHIFARAGGEEFYCLLEGC
DLNEAFEIAERIRKAVETVPHLHDQQLISMRVSIGAATVRDGEKISQTIAKADEALYSAK
QAGRNRVCVA
>A0A1J5R4U2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MDRKRADVDPLHGLTEQPGTALAARIVDAAPVVILILDGDGRIVYFNGHFERLSGWALDE
VRGAEWVERFIPQRLRAEIVELRRRVLRGQRNRGHVNPVLTRDGREIEIEWHDQRLSDAQ
DARQGLVAVGIDVSQRERAVREMQLSEEGYRSVVETMPDGFWVVDLDGRLREVNDEYCRM
SGYARAELIGAGIWLVEAIEDADATAAHIARVERQGFDRFESLHRRRDGNLWPVEVTVRM
NPALRRQFVFIRDLSAIKAAEAERLAAEQAMRHMAFHDALTQLPNRRLLADRTAQVRAAL
ARDGGHGGLLFVDLDDFKRINDRHGHDAGDALLVEVAKRLKGAVRAHDTVARIGGDEFVV
MLAQLPAERAAAGAALDDVAAKLEQAIAAPVRLGRRVLRCRASLGGTLFGAQDDLDAILA
RADAEMYAAKETRQRAADEMPPA
>A0A1J5RCY9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MVPLVPDGSVREGNARLGRPVMGAIRQVLPFVLATSAVPLTALADDGVSDGRAFAAGLGM
ITAMLPAVVVLTVRRVPAWIEWVVLVATFAGLMFLVQGTGGVHSGGLIVLVIPVVWMALY
ERPRQVAGALVLEAIAAFALRRADTTAHLVRQDVRLVTVFLTVSILIAWATARLVAQLAR
SERAARQGHATIAAIAGAARLIRESPDPRSAACEAVMTVSGASCVLLLETDGHEHLTITA
TAGVPFQAVRVGLAGPSAAVLAYRTGEPVYIGDVHGDPRVSPQLVALTGARALLAQPFSH
GGVVSGVVVATWPQPCPASAPEAFHTLELLVEEFGSALERADLYDALHRRATTDPLTGMA
NRRVWRAELPEMMTGCGVLCIALLDLDFFKTYNDTRGHLAGDAMLADLAKSWAALLRPQD
LLVRWGGEEFALAVPGCDLPEALEVLERLRASVPDGQTVSAGLACWDGTETIEALMSRAD
AGLYRAKNNGRDRTVMAIAGDFLPGTGPRRTR
>A0A1C6FCM9|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MEKVRNSPKDNILKGDLTNDSRFQSVYGKLLNCMYDVVIIYDNEKNKLYYDSDKYFDLFG
VKTNFTNLDQWFWHMCSNSVMQEDTELLDIFRSNDIFKRIKSGKYVVEDDIRIKNKEKGY
IWIRMVVVFIPNDRLDNIDSVFIMFRNIDNRKRLELDYIYKSQRDSLTHIYNKEYSSSMI
KEFLSGVREQNSVYGILDIDDFKNVNDTFGHMAGDVVLKRVADLLFENVDNDDIVGRLSG
DEFVFLLKKCGDVEKAKKRIERLLKRIRFEYTEGDETLNIQCSIGAAIVDKDCKETDALY
KKADRNLYEAKNYGKNMFIIS
>A0A701FHK3|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWGHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C3HBT3|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MTRTMKIKYAIYFFTLCLMTSFSLFIVEELLEAHTDYRDNQLNLYKIDRAKEISEAFQAS
LQAHRLKRLSLIDPQITRAQCLAADRVAREKITRIREHLNDPVARQLGVRQKIAALSMIG
LMEQLLDNDNLQLSQVNNANANLFNINSAYYISQTSKSYYRYTYDTRMVDTDSFMFLEAI
RLNNRLNMSLTELSDQIIDVNVNPLDRKDAYLKSIQLTGVLNALSTRLIFMKINYDDVQT
TELVNQLLTLVSAERLKQITDGLYTAINTQKPYPAALISRYVDELSGLSQALYQRSFELE
TVASRHKIYDSQTTIYGMIALAGLVVLLFILPALVFCTNINRWLTKTHNNIVRLSRGEMN
IDRNDAFYSRELIAISDAIQQLRQYQLDKVSLESEKQLLIKELEASSFLDPLTNIYNRRK
FFLECQLLGDSSYPQAFCLIDIDNFKQLNDSYGHDVGDQALVAFGHLLQRAFRASDIFCR
YGGEEFAVLLGNCSLDNARDIMEQLRTRTHRLTLNLTDGRQVRFTTSCGIAPVNAFTALQ
AAIKQADEALYFCKKNGKDRVSVHTQIGFI
>A0A379ZIT7|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MNKQMSGPAKLAIIGESAAYLLLIVDGCDTNRLSPYASGSLWIQDANHLVVRYPENLARA
HHFLLVFTLCLLGIVSRPGSFLAIFWPVNAVLLAVLVRRPQWATRAGWGMAVLGYLAADL
LTGSSLQKALLLNAANLTGVVVGYLLFMRLSPPARTLQRGASSMYLFGICLAAAAATGAV
GAATSQWLFGRPYLTSLALWFSSEFTNYVTLMPFILAFPADWRRRLAAAGALFTQRSQWP
RAGRKLTVLALLLLAAVCSVLIGGPGAVIFPMPVLLWLAMSFSLFCTMIAVLIYVLWCHL
AIDFGLLSATLDMKVLQNAVSMRLGIALLALGPIAVASMNYARNALLRTLEHVANHDALT
HVLTRNAFMQRGERLIDQKGELVCVMMLDIDYFKSINDRFGHAGGDQALMAFTRAIAADL
SVGDLFGRMGGEEFAIVSTLGQPQQGLQLAERLRQRIEAESITMPAGHPLQITVSIGMVT
CPGGSGHSLADLLKLADLAVYKAKKRRP
>A0A7W5Z3G1|diguanylate cyclase|EC 2.7.7.65|Pseudochelatococcus contaminans|TrEMBL
MFSQFVDTLRKEKSLEGAVRRFLGLIEFSTGLESAYLTHIDSSLHVQTILFARNTGSFVI
PEGLSVPWGDTLCKRALDESCIFSDDVPGRWGDSKAARQLGVQTFASIPVHVDDSLYGTL
CAASSRRKAIDSRNRRLLAVFSEVISMYLERELLLNQLTDANLQLEEVARVDPLTGLSNR
RHLMAEMGRIWSFMRRENRPVLVAFIDLDGFKSINDQYGHDVGDEFLVAIAKRLKGAIRP
YDLAARFGGDEFVVVSAIDADEDQPTTARESLRGRLEASTLGPFELPSLKLDYAGASVGI
VDAAVNDLSPEQAVKRADEAMYMVKSRRRSLMAKDPRGACQPEGNAR
>A0A1Y6M592|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MNEISLADFHLTMQVLDNLDAGVVILDENYNVCAWNTFMQAYSGISCTQIMGKSLFDIVP
DLPELWLKNKIRSTFKLRMHSFSAWEDRPWVFRFLNFCPISGSSDIMYQNMTITPLRSLS
GEYKHICLTINDVTDIAKNKNHLHESNKQLTHLSITDRLTQLYNRGHWENCLADAFEYCQ
QTQTPATLVMFDIDHFKRVNDTYGHVAGDGVIKVIADVLRRTKRQTDIAGRYGGEEFGII
LPGTSAELAGYFTERLRNRIEQETVFDDQRGIVKVTISLGVCEWNPKLIDYKSWLEKSDL
ALYESKKKGRNTTTIINSDNCYTDSKGEFILTEVDGNTTIN
>A0A090NGZ4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MKLRHPGGNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKHESFLICSCTDI
TEERRAQERLRILANTDSITGLPNRNAMQELIDHAINHADNNKVGVVYLDLDNFKKVNDA
YGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASQILTRLRL
PFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRV
FEYLWLDTNLRKALENDQLVIHYQPKIT
>A0A6N3QKS7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MEMYFKRMKDEWTGLVERADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGISPV
>A0A6N3QN77|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDV
GPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLI
FLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTG
LYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVL
DGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGSYLCLFDVDKFKNI
NDTFGHLLGDEVLMKVVKILKSQIPVDKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVH
FQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A090NDK5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MAKPLANARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDV
RSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAQNAQLLRTALHDPLTGLAN
RAAFRSGINTLMNNSDARKTSALLFIDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGL
RHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTI
EHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2X0YRY8|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MNSQLTAFITLSCTSGVLNLYLCLYVFLKRYNYTKIAQLFISYTALIAVYCFASAFGLIA
TTLSAIKVWTAIQYVGMAFSTPLGLLFIMQYLGFHLTRKKIMALLAIPFISLIMVATNDI
HHFHYRVFEIDPILGAPYIHQEIGIWYIIHGIFTFGCMFVSFLLVLIHWKETTKAYRQQL
IALMCGQLIPMITAFIYLLGLTPQGVDPVPMVLWASSFLYLWSINSSRLFRVMPVAKDAI
FHSINDGVIVLDESARLIEFNQACSKVFPQLTRSMIGRDIRKTWLEVTGQPMPSTLEAVV
NTQDIEMVLSDHTYQVRVTELQHVNHGKGLLLIFTDITELKKLQKQLEQLAFYDELTQIY
NRRAFFQQCNQAYSEARESSSAFTVILMDIDHFKNVNDTYGHAIGDQLLVHVVKVCQSVL
KKGELFARYGGEEFVLALKDSTLLEGQALANLLCNSVESQPLMTTEGAIRATISCGVAEG
TKGQETLYQLLNNADKALYAAKQAGRNRVHVFLE
>A0A6N3GWK9|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MTKLLKKIRFTTIVLILGVALIVSSVFSLLTIQNLEGNARVINYSGIVRGATQRLVKQEL
NNEQNDALIGKLDAVLEELQNGGEKNNLVKLADPEYQGLVSGLQSKWGELKNAIYDYRSG
GAAGPLYGISEEYFELADQTVFAAERYTEQAVKNAKYFLFLVTLIFLAMVVVCAFFASSQ
QKRREKLLADEKEALERQIHLNQMLNDIRAPLDELPELMYVSDLENYDLLFINKAGRDSF
NFKDTEGKKCYELLQGLDAPCPFCSTPNLKPEEYFNWEHTNPITGRHYLLKDRLIEWEGR
PARFEIAFDLTEAMREKQNLKNMLETEQVIVECIRDLYQNHDLPQAIPLFLERIGKFLRA
DRSYIFDLRGELLKNTYEWCADGIKPEQEDLQSIPRHYFSRWIEAFTEQEYMIIDDCEDL
KITTPLEYEVLSFQNIERLVAVPLERDGELYACIGVDNPPPELMQNAVSILQTLRYFLML
AIRRTEDEAELTKLSYYDNLTSFYNRNRYIQDLEAFTDYEDSVGIVFLDMNGLKSVNDLY
GHSRGDRLLVECARCIREGFGESNFYRVGGDEFVIIALGDTEAGFFDRVEKLRGYFEHSS
HISTAIGAYWTPRGSDIDAAITAADERMYSDKQVFYHGHHTSKRYRYINDDVVIRSEKQT
EEKISQ
>A0A1S7RPB2|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense Zutra 3/1|TrEMBL
MNEIIDTNVFNLAPVAMWIEDFSEVKSQFDIWRSQGVEDIRAFLLEDLSRVAACSQKIRV
IKVNARTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSELWAGKTEFTSNAVNYSIGG
KRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKELLNRRYAEGMFKHSPVSLWVE
DFSRVRRLIEEVRDRGIVDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLTHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDELNRLERSALRPVSAIVIDLN
GLKDANDRLGHDAGDALLRRVGEVLNGVVTAPNHAARIGGDEFAILLPGADKQIAAAMVE
TVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRADMNMYEQKNAYYAALRNRSA
DNNDTTKPGPQSEASSLKRLS
>A0A2H6AZS7|diguanylate cyclase|EC 2.7.7.65|bacterium HR40|TrEMBL
MAACGSGIDEGAPERHLEPVRLPPLPSMLALWLKLVNSAARLGAALVVAGAAALVAGLLA
WSLTRQTDERLAIAATAAVAAAVGSGMPALWLARAAGEWVRARAELYEQLHRWRHVELRL
RRLADTDDLTGLLNRRAFFERGATFVALARRYGHSLALALCDIDRFKTVNDRYGHAAGDA
ALREVATALRSEARASELVARLGGDEFAVLMPLTDLEGARRYAERLRERLRRQADFGLTV
SIGLAALRGDEVDLDRLLTTADRMLYAAKEAGRDQIFPPPARPSPAA
>A0A3P5WQN4|diguanylate cyclase|EC 2.7.7.65|Arthrobacter ulcerisalmonis|TrEMBL
MCEGGSSILRSTPNTLREFPRHEKFAVGTCQRLLTYWAKNFRKCLGRGLVELDETTLRVT
FGTVILGLVALFYFAAYRPTRSPYSGWWCLALLFFLLGSSLYLLDGTPHQVWANPVGNAL
LVQGGVAVWAGARSLRTEKFPAWALLGLPLLTLIAAAVDAPATNAWAGGEALLASMAVAI
GMSSWEVWRIDPGYTRLKVPLSISSGALAIFYLLRLVALVVEGQHGHFFTTVFGSAFTTM
ITLALLVMVSFTMAALSSEQQNRALSAEISRDDLTGLLNRNAFLELAAVELGPQASRARH
GALIMADLDHFKAVNDTFGHGAGDLALKNFADACLETVRTTDLVSRFGGEEFVLLIPGAS
PERAEVIAQHISTRLAASPTAGDMPMPTASYGITTYDAGTTDIEAVITAADTAMYLAKAQ
GRNRVAHSD
>A0A2S6Q4I2|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MKSIEQTRKEFIQRDLESVMSSPELDIRLVCALAGDRNLNAREINIVEKLYKSRKEHFYC
DILYALTYKSFSALQAKSIWEGILQHRKNLESKLGRDVGLSVTVHDYLENILKNMNYCTI
IEEQKLHHLTTVATKDGLTGLFDQASFKRKLSEYLDDKLQTESDLALIMFDLDNFKKVND
NFGHPEGDRVLKEIATILQLCARREDLAARYGGEEFALILPKTNYENAQQVGERIRQRVE
DYFKEREYTVTLSMGLYHLAKKSYISSLELIEKADQLLYTSKTTGKNKLTSSNM
>A0A857JPE7|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MQDMKDLAEMHWKHDLLGSIEVGIVVVDRRYQVQVWNLFMENHSNIAPSTIRDKSLFDHF
PEIDESWLRAKAEPVFSLKSPVFVIWEQRPYLFRFGANRPITSPSQFMYQNITIFPLASL
SGQVDQVCIVVYDVTDQAVSKQAVDDLNNELQRLSRVDGLTGIYNRRYWEEQFEREFKRN
LRTPGESSVIMLDIDHFKKINDTYGHPAGDEVIRQLAHLIEDVSRETDICGRYGGEEFAI
LLPDTASENVMVLAQRIRTSVEKLKIEYEQHTISFTVSLGIAQFNTAFGQHIQWLEEADK
ALYQAKKNGRNQVIIAGS
>A0A7G8QNC9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. JUb54|TrEMBL
MDKPLWVSKLLRVSNPGHVVNYCFVIVLFFSTLLIWREVMVLEGAYVTNQRNNLENVSHE
MDSLLQFNIDRIVFFRNGMQSALETPLDFEILRNAEQEYMAKRHLPIWSVALHNRRTLPI
YGVSDAFVESESTLSRNDTQTGNEMMAALELGYLLRLANTNRGFKDRMLYISRSGFFTTT
ETPKSLALAQEWYSKAIVAPWFTRQSLRNNPGRGVVWQTVLDEDTQTDNPVVTASIPLDF
EHDWLGVLSMDFSVREMKAFLVRAIKGGQEGEYQLYDGKMNLIVSSDEGNVLAQLSPREQ
AMLSYAFLHDNRGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGDFGTITIALTLMWL
LFTLMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFDRAIAAAKTCEQSK
LAISVIQLDLDFFKKVNDLHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCIVMPG
TTSQVARAVAERIRLRIYSREILLCNDTSLRISASLGVSSSDETGVYNFETLQSVADNRL
YLAKQNGRNQVCFAETL
>A0A1W1I5Y8|diguanylate cyclase|EC 2.7.7.65|Nitrospira japonica|TrEMBL
MSILIIDDSPDDRALLQSILSAAGYDHILSAESATTAFRLLGMEGGKQSAGRIDLILMDI
VMPEMNGIEACRQIKAVERYRDTPIIMVTVKTDPVDLQLAFAAGALDYIAKPINKIELLT
RVRSVLRLVHEIERRRAHEQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAVRESTPLSLIMLDIDRFKSYNDTQGHTVGDECLRQVANAISGAVNRPGDLVARYG
GDEFVVVLPGTTTEGAAQVAETLRRRIESLGITHSEGDVMTISVGYASTIPNRSASQTDL
IKAADQALYQAKQEGRNRAKQAGILSLVPHSHEE
>A0A3S4SWV2|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MVRGCRVENTSSLNGFGHGIEQWVQQMERLRPLAGQERQQLLERLLAQRDLDALLAIFAE
RVAKVVRIHSLHLDCGQPHSLICRPPQTHQVLHSYRFELRGQHDQRLGLLQYELEQPLSD
DQQRLLRQYHQLLCLPLPLYLRLDGLERQVRLDHLTGLGNRSYFDEAIGRAVEQHCRESH
GLVLVLLDLDRFKQVNDTWGHPVGDLVLSRFAQLLNGCIRGTDQAFRLGGDEFALLLQPA
DPEAWRPVWLRLQHVMHSHEELSAFAVSCSLGAASWQAGVDVQSLYEAADAHLYARKRAG
VTDPSE
>A0A3S4V0L3|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MDKILQALSERVTEARDLESLTRPLLEMLEAVTGLESTYLTEIDLVQGKQSIRYANNANN
ANDVAGLQIPEGITVDWSDTLCRRAIDEGRIYTDNVAECWGDSQAASALGIHTYLSSPVR
TSSGSLYGTLCAASAEHKPLVAGSEQLIAFFARLIAEHVEREQLLQQLQRANQELSRQAL
SDPLTGLPNRRALMHELNRLFSLSERAGHPVLIAFIDLDGFKVINDTHGHEAGDLLLVTL
ARQLSAALRGGDLLARVGGDEFVAVGMGPHRGDESIEVAVQRFQRRLFEQSVLQLPLPSR
VLHYPGASVGVVAIDPAHTSIDDALRQADARMYAVKRQRRTLG
>W9VFD2|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MLICPGTRVKNAEQIAEKIFKAIQQHSFPKKLRITVSLGLSEFTATHSPETLLVEIDQKM
YRAKQAGRNRIQI
>W9UQZ2|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MLKAKRKGVLSLRSVLTIPYVVLVVCLALSIGGLSYQAGSKAINTLIDQLLLETVGRITQ
AIDRHIIGSGAVLETAFPIGMPAPIPIESDMANLKTRFWIATSLHTDPNDYVYYGNEAGQ
GIGLQRLSDTKVELRLKLEASEYRKIYHYEGIDGEMQQVREEERLFDPRVRPWYLDGKEL
RGHTWTSIYIDFGTRQLIATRARQVLSHEGVFEGVVATDVSLRALNEFVGHLRVSPHGIA
FIVEPNGKLIAASNTPNVLPTGDGEFVRVAVEDVNVPIMSDVYRAVIASIEEQGVPDETR
PLSLVFDDQLIHVAFDRVRDDAGLDWLSIVAVPDSDFMSGITENIKRSVYIAVVAIILAI
LIGLAILNWVAADLRKLKEALVRVGDGELDAPVNIYRRDELGELARGVEQMQKRLQTDPL
TGLMNRDAFTLKLRKLIEGDQHYRRQQSMAVLFIDINRFKHINNAWGRDAGDLALKEIAT
RISNVIEADDCLARFSGDEFVILLRSAERPDRVRRIMDQINQALSEPLVCLKMDPWLSLT
AAMGVSYYPTDSIDADGLVRLADYAMYREKESTPMHSS
>Q3YWZ7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1V5Y4I6|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin182|TrEMBL
MAATLQSVDLSIVSLLILLFIYLSAFNRLEKIFVQYNLFIGLIFINMILIVVDILAWVFN
GLPGQANLLNNMKSNLLLYVLVPIAPSLWVLYVDYQIFRDEKRLNTYMNILLTLWAVSAL
ISCVSLKTGWFFGITDNNIYYRGRYFYLYAAYCLCLLAYSFFLIMLNRNRIERKYYFALQ
AYLIPQLTGTILQLMFYGVSYNWVGMMLSLLLIYSNIQNSVLNTDSLTGAYNRNYLEAYI
RAKLRKGVKGSSFSALFVDLDDLKRINDEYGHRIGDEALRDAVGILKKSVQKEDFIARVG
GDEFIVVLDISDSLRLKKTAEKIKENASAFNQSGLKPYHLNFSIGCDVYSSEKYPDPETF
IADLDRLMYCDKRKAHGIPS
>A0A4S1E5G7|diguanylate cyclase|EC 2.7.7.65|Alcaligenaceae bacterium 429|TrEMBL
MSNVAVYRLASDWQKALKKIPEHIRCYVKEAANSHKELLASYFYASLLNDQAANVFLSHD
EVQKRLSRSLQKWLSELFSVAPDDDFVALVELQRQVGDVHARIDLPLYLVLSGARLLKER
FFEIVQEEPSLELIDKMAAQQFIAESIDIAIEFMSRAYAASYDRKSRAEESYRVFAAVHN
SAAERGRQRAALLDWENNLMFELATGMVDKQLSTINSSEFGLWFHHKGAHAFENLKETQV
IQNTMEHIDQEVLPRFTQANSANQLDVLRELRTQTRLILLSMDLLFEQQNEVEAGRDTLT
KLLGRKYLPVVLGREVAYSRRRGVKFALLSIDLDHFKRVNDEYGHESGDAVLRQFAELLN
AQCRAGDYIFRLGGEEFLVLLVDVNVDTALRIAKKISERIQREKFILPFGHELNLTASMG
LALYDGHPDYTPTLRRVDKALYQAKHAGRNRIELMT
>A0A5P9D367|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. THAF82|TrEMBL
MLGKRKNDSAPHSLSSTGLNAGRKITVWIYGLAALLIVLSAASLTFIAHMAWREADRKAL
ESEQMRMDAMLKDIHWQIGRDQLSLAQWDKTFNAVQAPLDKEFIKDELVEYLWEDYVLDR
TFIVGKDGMLIAEAVELETRFEPKQLPPDNLIRKLADQTRADFEAKRGESGSVFSDWYMP
QSVLLDLSAATFALVDGTPAFLSAMPILPDDGQVQLNEDYPLVLVNAAYFDEDWIAEIND
QLSFKDLHFQLGMPSQDDVRNHLVVAADGSVFGYFRWDHAKPGREIWAAALPLIFVLATL
IAVVAFAAASKISRLSTSLEESERKNHYFARHDALTGLPNRHHFSDCLAFALDNLPDRPF
AIFTCDLDRFKPVNDTYGHEAGDKVICAVADRLQGLVADKGVVSRIGGDEFIILVTSLSD
KHPLQLLANQLRSAVAQPFDIGNGQQVEIGISIGIATAPDCGATEKDLIRLADMALYRAK
DNGRNAFEFAMAPSAPDAGDMSGFTTQSKLH
>A0A4U9HCW9|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MPRALAAQAVALGEFLRQQVEKSEVNIGHKPLKITISVGVASLAMKEVKSWEQLMNMADI
ALYRAKSLGRNRVESFNAVSGSSVDHIWFKE
>A0A447QNX2|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MMGLFRRKRAAHARPTLGQVLQRMNLSLALIAVGTAGVFLTLVALFALRAYANHNLHLIA
RSISYTVEAAVVFDDRSAAREALMLIASNEEVSEAKILNKDGRLLAYWHHPKDGPLHGLE
QMVARWAMPEAIELPITHEGKQVGKVWLSGHGGSLLRFLLRGLAGIIACLALSTLCALIL
SRRMLHGIVRSLNDIANVAHVVRSDRSFGQRVPSAPIAELHELSNDFNGLLEELETWQAH
LKQENDSLTHRATHDSLTGLPNRAFFESRLSHALNHIAPEEKLAVLFIDGDRFKEVNDSH
GHAAGDAVLTAIAGRIRAQLRDGDVVARLGGDEFAVLLSPVRRQADVTRIADKIIGSMAQ
PVPLPNQEQVIASLSIGIAFYPIMRQRLRGCCTKPMTPCIRRSIVITEVGGWRPRNSHPN
RSRGKQGIIMIKQRLTRPFSLLAMMFIAVLALAGCQSKQGLTAEQIALLQAQGFKLTDKA
GSSACPTRCCSAITSANSARKAQRRCRKWGARC
>A0A2X5BLD1|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MKVKYLIYFFTFLLTASFTISICDEWSEAKEQYNDSAWNLSKTQHSEDVSGAFQNSLRLH
RIKRLSLVNPALEPALWQETERQTRNKIQQIRRYADSDARQQLTTQQKIDIRSMLNLLEK
MLNNDTQQLAPMNNQIRNLFNINSAYYITQSSMDYYSYTYESRILNADAFLFLESIRLNN
QLNITLTEIIDQLVDIKLNGLNDKESYLKTIQLTGVLNVLSSRLLFMEMVYSDPQVSRII
NQLLENLSPQQTNGLAGELYASMAHGKELDATRIYAYVKELDRLSQQFFQRSFDLEIEKC
RKKMYQSQTAINGLIAFAGLLALFLLMPTLIFCSNISRWLTKTQGNIQHLSQGNMAIDAP
EVFYSQELIAITDAINQLKQYHLEKVRLEQEKHALIKELESSSYLDPLTNIYNRRRFFRE
AEQLPAAGYPLAFCLIDIDNFKALNDTYGHNIGDLALVAFADLMRHAFRAEDIFCRYGGE
EFAILLHHCALPDARAVLEKLRHRVQRLRLPVPDGQPVRFTISCGIAAVASPHQLQSAIK
LADEALYFCKKNGKDRVAINTGSGCR
>F5P2J5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAILASIKPAGVVSRADVVL
PNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANPQPIAYLVLQADSFRMY
KFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIARELNAIPAQELVGHQLALP
RLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNKALLMEMLEQVVARKQT
TALMIITCETLRDTAGVLKETQREILLLTLVEKLKSVLSPRMILAQISGYDFAVIANGVQ
EPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTAEQLYSRAISAAFTARH
KGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMTSGKLVSAEVLLRI
QQPDGSWDLPDSLIDRIECCGLMVTVGHWVLEESCRLLAAWQERGIMLPLSVNLSALQLM
HPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRPLRNAGVRVALDDFGMG
YAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQSLNLQMIAEGVETEAQR
DWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A5P9C9K5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSSSATSPPDARHCAAGVAALVCLLVLGACLLGILTRPIGHLAALWPANAVLLGALVRFP
RLARPAGWCGALCAYLLADLLAGSSLQQTLLLSAGNLSGVIVGFLLLRRLHAGHRSLRTP
ASVPYLVLAIVAAAAASGCFGAITDPLLYGGKPMGGWVFWFMTELVNYMLFLPVMLTLPA
CRAVRTERRRRPLWTAEQARKLLPLLGLLVSAALCLLIGGPGVVAFPVPALLWCALSYRL
FSTALLTFLASGWVLVSIALNGLSLAPLDVNSRPVLLSLRLGVSLIALAPLTVASVMSAR
NELLQRMRYLASHDQLSSLLNRWAFREQASEQLSLLAQQQRPLALLMLDIDHFKRINDNH
GHAAGDQVLKAFANLAGSGLRKDELLARIGGEEFALLLPGCDLEQAREIAERIRQRFGDT
QVQLDTQTISCTLSIGAVVAWPPFGDLDGLLLAADRMLYQAKALGRNRCEITFLGGASEP
GAEPPGGPL
>A0A2G4AYT6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MYLQSLEFRVFDEWSDKHELWNTLLDDGLLQVAFLLIAYGLTELISKLKDQSKLDELTGS
YNRKKFDAIKLEEFELIYFDLDGLKMVNDRKGHQMGDLMIVRFSQALNQVTLEDEMVFRV
GGDEFVVTAQLGRGGKFVKQVSRLLQGEEISFSYGIEVTCRDNFKQALVESDRAMYEMKK
AQRSETEKS
>A0A7X0SUV8|diguanylate cyclase|EC 2.7.7.65|Pantoea stewartii|TrEMBL
MIVDALASSDKSPNSWLHACGLGLVSFVLTLFCLELIVVSGKISPLWFSTALMTVVVFRC
TSRQLPLFLAACLIGTAAANAFVIGPALSNLKFALLNLLQAGIGGMLLRALLNREAPLVS
LRDWLRFVFATGVISPLIGGVLALWVLQVGQQASFAFFYTWVISEIIGMLALGPVLLLLS
WPLPKGYLRRASLFETLFSLVLTLIASYLSLRFLPWPFTFILVVLFWCAVRLPKVEAFVL
FFLNASFMALLLSLDWIIVTPTTTNYAMIVSWLPFLMVLIPCHIMSLVMDAFRHETRHIS
ESETRFRNAMEYSAIGMALVSPEGRWLQVNKSLCDTLGYPEYELKNLTFQQITHPDDLGI
DDGKMDKLLAGEILSFTLEKRYFRKDHEIVWVRLTVSLVRDSEQQPLYFIAQIVNISELK
QSELVNQRLMERITLANEAGGIGVWEWNMNSGEMLWDKRMYTLFGLQSDEVPSFDLWIKL
VHPDDRAFCVQTIQQAIEESSAFQMEYRVIREEGHYWIRSQANRLLSQEGRIERILGVAQ
DITPLRNLNEALFQEKERMMITLDSIGEAVISTDQAMRVTFMNPVAEKMTGWSQEAAVGR
PVSELLHITHGRHGAPVENLMINPTHSEKTAPYLSEEWVLHTLNGEHIDIHYTITPLKSE
SGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHHLRSTDFLARLGGDEFAVLMPECLV
DQARDVVQRIVRAVNDYCFEWLGRAYQVGASAGMTQISPNNCQSSDVLSQADIACYNAKR
SGRGRYMVYEQHPLALTGSHHSLDQATLDALQVELQVWAVAPPGKPHSASVWLIEVQLFT
REGLLVDEHLLRNNLTDAALKQRLEDNIVEAFFRHRIAAMSQKGIALILPVDVNALYNPV
FVEKLCVRFAESGLANSNSGIALHAASVLSGGEQLLGTLMKLRQAGCRIVLQQFGRNLDA
FNQLTGKVVDCLILAPELVANLHNNLMDEMLISIIQSQTNERNIILLAGPVSVPAVLTTL
TSLDVDGVWGSAVAERQPLSKLSEDHLFAIR
>A0A2G4AY05|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLKKVVLLPLFGLNFGLSFITLKFIYPEINLNSHFYFSCSVIVIWTVYIGMSGYQYTHKK
FIASLREQKFLRRITLQNMQIESLNVKLGHTSHIDALSNLYNRRYFDRKLNDEIRRTQRA
NTELGLLIVDIDHFKQINDCMGHDVGDKYIKLVATTLQSCVKRPEDIVARYGGDEFAFIL
PNTHMLGLKTVAMKINQKVRDLELAHPSADRLTVSIGGALLSSANNCQASLFKAADNNLY
KVKRTTRNSFNIS
>A0A174EYR5|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKGLDKLQEENERLKKLASQDSLTGLLNRGTMEETVSEVIRHDKAGVFLIMDIDHFKQIN
DVYGHLTGDKVLQELARVIGYHFFKKDLIGRMGGDEFAVFIQNACKKEMVESKAESLYSR
ALQVGREMGIGNRLKVTIGVEQFREGDSFQTLYSRADCALRYGKREGRNFLNYYRDSMAL
HKTASQNGEGLPAAPHDMKYICRELKEPDFSREANCQEYQTFLSIYRFLERSLERTGIQV
ELILISLTDPSGAFVNLGEREFLVQQLRESICSSLRFNDIYTHYTSCQFLVMTPGAGSSH
MEMITSRIRNKFLELVQGRPDVRLFFSFYPLQQTAPRRQ
>A0A383RRL2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MKGTRILEAPRLLGIIWPFVAVVVLQVLLGSLSLYTLSAVRAYVAGESLWSKAQKDAIYY
LSLYAENPDERTFQRYRQAITVPQGDHELRVALDQPTPDLDAARAGILKGGNHPEDVTRI
IWFYRNFRHISYMETAIAFWDIGDDFLRQLDLLADEMRATFAVGPPSARQVSDWKARIVT
INEGVTPAAKAFSDALGEGSRMVLKVLLITNLLTALFLITIAWRRSSKLLAQRQAFATAL
QAEKNRAQVTLEAIGDAVITADVEGHIVFMNPAAEQLSHWQAGSAQGLPLTALFTLIDEH
AERDERSLVEQVLSGSLRGGAEHARLIQRLDGSTVSVNLVGSPIVNAGQVSGIVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEYRLEQALNGLARQAGRHSLMFLDLDQFKLVN
DTCGHAAGDELLRHICAVLQSCLREGDTLARLGGDEFGVLLESCPPDQAERIAEQLRQAV
QTLHFVWKGRPFITTVSIGLVHIAQAPSTLETSLRAADMACYMAKEKGRNRVQVYHADDS
ELSMRFGEMAWIQRLHVALEENRFCLYAQEIAPLSAQDSPGHIEILLRLHDESGRTILPD
SFIPAAERYGLMTSLDRWVVRNVFQVIRQCLDEGRPGPLAMCDQPVGFEHR
>A0A4V1RHM0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp. 743-2DZ2F-22B|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPSLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMHDALETPLAFGALHDAVKRFAQLRTSPTWQIAVDK
RRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYHHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSESPAVDVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFDQAKILA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHLKK
>A0A2X2BYH4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MPYVVERRNLLIEAVMGGFWVAAMGLNALPSTMMISMYCLNSIAVGAPGLLWKSLLAQLA
GLLTAWTLLGFKFIPETSHLQVYAYLPMLAIYPMAVGGAAYQLAGKLAQHKRALRDFSRL
DSLTGVLNHGAWKESLEAEFVALQQGNRSAVLALIDIDRFKSINDTQGHLIGDEVIRVLS
DVLKANCRASDIAGRVGGDEFAVLFKAADCAQARLALARLQQCFRKVLEEQNHLPVVTLS
IGIVPYDQAMTDAQLWLKCSDQALYQAKHNGRDQLAQFERHNEG
>A0A517Z4S2|diguanylate cyclase|EC 2.7.7.65|Maioricimonas rarisocia|TrEMBL
MASEQQTRNLPGRLSLSTGSAAPCPPTVHQDTCLKAIRPEIGTHPYILATDDRGRVVGIV
PSYRILERLDADNDRERTRWEGMPLQALISTKLRGGGQHAGSALDSQLDCVVIAEGETVV
GISTDEDVFLSWRRLESMLSAAVSDPLTGLMNRLAYDRRLSEEWARSRRTGTSVGVVLID
LDKFKPINDSFGHHAGDDVLRGLAAVLETGLRSYDVVARYGGDEFVALCLDCRAGEIDVP
IRRIQQGLARQRFEFGGTRVSVSVSVGAAVRHDGFEDNDPRELFAAADDCLYRAKRSSAD
AYVIEFGADSDATVRYVDTGFEDSQIGAAFVR
>A0A6N8HIT5|diguanylate cyclase|EC 2.7.7.65|Lentibacillus sp. JNUCC-1|TrEMBL
MTPESMNSPIHEHIFNVLKEAIVFIDEEGLILQSNDAARSLLESKDLTKRSILSCLNFEG
FSRITDTHQLVPLYNKPDKLVDVKVVSIEHGLYCMIMDELSLEERKAEVKEYLGELEQIG
GEGMVVLNGNQIVDADETFSNLFGYSLQELKHMKLTELVQDICTIPHYDQYIGNHVRDCE
QVGIRKDQSTFNVEINEKTYINHEDGTTTRVALITDVTAQIENEKQIEYMAYYDELTGLP
NRNFFIQTLKRMIEEAETDGEMLAIYFIDLDYFKEINDTLGYAFGDALLQACGNRLKTFL
QSGRFIARMGGDEFLLLQRNIRQESDATSLAEELIKEFEKPINIRGYEIFITLSIGISIY
PKNGRNANDLIKHADSAMYVIKEKHRNNYNLFEASISENFKIMLTMENEMRKALKDGQFL
LHYQPQKSLDSGKIVGVEALLRWQHPTKGLVPPGDFIPLAEKTGLIIEIGDWVIREACRQ
NKQWQDEGYSPIIVSVNLSAKQFHQRELVEKVKQALDETDLAPEYLELEITESMAMSNEE
YILDTMKQLRELGVFVSIDDFGTGYSSLKYLSLFPITKLKIDQMFINGKQQQNKAIVKSI
INMSHSMNMKVIAEGVETKDQLHFLKSEKCDEMQGFYFSKPLPPNDVQTIFKTVVLPY
>A0A5E4RBJ3|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MTHSAATPATDDPIRAAQDLWREALLLPPNLPSDDMRGRMSATPFMQLPSSMLPVTELLS
STRHASPARRDMTTPGAPSPHAVPQESLQSLRPTSFSPNTGATIDEAARLAALRRYDILD
TSPEPAFDRIVRIASYIVGAPISLVSLIDETRQWFKAKQGIDATQTPRSMAFCAHAILGD
DVLVVPDAHADRRFADNPLVTGDPHIRFYAGAPLRTPEGHRLGTLCVIDRRPRTLDPEMR
ALLADLSALVVDELELRRVNQVLGDMAMRDGLTGALNRRAFLMQAEQAFANARAQRRRLS
VLMIDIDHFKAVNDTWGHAIGDRVIVELTLVARATLRKGTVMGRLGGEEFAVLLPEADAQ
RAMQAADRLLSAIGNTSVPGATGPVRFTASIGVGSLSADDADFGAVLQRADRALYTAKQS
GRNRVAIA
>A0A0M6YK43|diguanylate cyclase|EC 2.7.7.65|Jannaschia donghaensis|TrEMBL
MTVVSFDLAALQGIFPMMILFDHDCAVTAVGPTLERMAPGALGQSLRDVLGFVHPPVVPD
AKGIFDTKGRRLRVQLLAETNVPEGEDPVILRAVVIPLTDGRGMVKLTFGPDPALALRRH
RLTARDFAVTDPMVDYLYLIEVHGLLHSEYERLSDRLDLARDAAERAAVTDKLTGLHNRR
AMDAHLTNLTTSAVRPFGLMQLDLDYFKAVNDTYGHVAGDRVLEEVAGILREEVRAEDMV
ARMGGDEFMLVFDNCTDVDLMCRISDRIIGRLEKPIAWEGHSCRISGSIGITMSSYYDQP
DPDRLVSDVDAALYAAKRAGRARTTVFDPQSPPDDVEAVG
>A0A649YM33|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MSYNRLLHAHREVNKLLTKLALGMGKAELNRRVVDLSEHWFGERRASILRLDEPTQQLHL
EYAPSLPDFYNQAIEGVEIGENVGSCGAAAFLKRTVVVEDINHHPNWAPFLSITEKANLR
ACWSVPILANDQTVMGTFAIYSSQPSKPSEEELEVLEMLASLYAVAWEKYQLEQQLHYHA
SYDCLTGCLNRRALLQRASDCLNTNLTYVACFFADIDKFKQINDKNGHEAGDVVLTAVGH
VFKHCFSESGISGRYGGDEFVAFAFSDDEEALRILHTELRESLAEITPLHTIEVNVSVGL
SIVNIERLDSIECLIKQADKQMYQIKHHH
>A0A3N4AH73|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. SSM44|TrEMBL
MPRLSTEQLSMEWGALNQRFSAHSRVFILDFCQRHAQPLAEHFYQQMLQDPGASPFLSHD
QVSSRLHSSMQRWVAGLFAPQTHEDLLRIIAEQQKIGEVHARIDIPVHLVLRGARAMKVE
FIRLLLADGRLCGDEYLEVARLMSDTIDLAMEVMSQAYASSHDRNSRTEEAYRLFSVTQN
IASEKERQRGALLDWENQLMFGLATGLSIAQLPRIRTCEFGVWFRHKGAHAFEGTPEASQ
IIHGMVQIDDVLLPLFAEEWRDRVPQLREMRDLVSTIRFNLDHLFEQNSELEAGRDVLTR
LLNRKFLPVVLSKQITYARNHGAEFAVLVLDIDHFKRINDGYGHEAGDRVLQQLAALLVN
NSRAGDYLFRLGGEEFLMLLVDTGLNGARRAAEKLRASVEREVFRLPQEQTLSVTMSIGL
ACFDGHPDYQQMMRRADEALYKAKEGGRNQVVQAI
>A0A1G4GAE3|diguanylate cyclase|EC 2.7.7.65|Petrimonas mucosa|TrEMBL
MDIDFSKFTVLAVDDIPTNTLLIKMTLEQSGLRVITAQNAEEAFQLIEQERPDLILLDVL
MPGIDGFEMARQLKEHPEHKWVPIIFLTALDSTTDIVKGFQLGADDYVTKPFNKEELMVR
VSHQIQLLEAKRTIEQQKKELEEIIAGRDAMYSVIAHDLRMPMATMKMILNVLFLKIKEN
EHTCNDLLESVQSANEICEELYILLDNLLKWTKSQLGRLKALPQFFYLGEFIKGDVEVAA
AHASTKNIGIRFESVNNEETGVYADTDMIKTAVRNLINNAIKYSYRDSEITISIEREADR
VICKVADTGCGICEKDQARLLNPATHFTTYGTENESGSGLGLLLTDTFLKLNNGLLFFHS
KQGEGSTFGFSLPAHTGK
>A0A1M7YZV2|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MSLSRKISTLFIVLLSFLLIVIIYSIYKLRLIENEMNEVAYIDIPLNQIMSEVEMIQLER
HILFEQFKLKEKLPEEKKTPHQEFIYQKQQLKLLLDKAVNVIAENLVNHKIRFELQEHRQ
LLKVIEGYHSQSDAFEKKLAGALSHESIPDEERFQLEKEATDLESSVNTILQRLDEMTFE
AGRYAEKHEQEFMFVNTALGVGALLLGLFLTIYTIHIFRRRINKIQDGIQNMDFSIEQGY
QALGEDVFRADGPNDELSELEQELIFLMQRLTKEINNREQVEKQLLQMVTQDKLTGAYNR
HKWDEQVLQYLDLARRGSAFSLILLDIDFFKHINDEHGHQIGDQVLQNLVHRLSSGLRKT
DMLFRLGGEEFAVLLPVQDASSACLLAERLRESVSQDSEEGLPSYTVSIGVTSYQESDTE
ESIFQRADKALYQAKSSGRNQICLM
>I6CPF1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALVLVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLLFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNTMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVLL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGDSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLGNSPLPPRLLHLIIPAEAILDHAESVQKLRLVGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIARPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A5V9GPX4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Wandsworth|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2W1J8S0|diguanylate cyclase|EC 2.7.7.65|Acaryochloris thomasi RCC1774|TrEMBL
MDPHPLTVTAMTLLKDVVVNMSQSSTVCTLALASGEATSDQRRSYALVMMEDKLLGILTE
RDLVKKIAEGACFAEMMALEVMSTSVITLNASEIKDVFTPVNLMRQYRIRHLPVLNDQDE
VVGVITSARLRQALPASALLKRRQVAEVMATQIITAAPSTPVIEVAQLMAIHRVSCVVIQ
ISEAHSPQGIITEYDIVQIQRLELNLTTLLAETAMSSPLECLHPEDQLWEVQQKMQQLHV
RRLVVVNDQGILAGLITQTSILSVLDPQEMTSTIEMLQQQVEQLQDERVKLLQERNLNLE
TQVQTSESSLLVCQEKFRATFEQAAVGIAHINLDGYFIAINQRFSQVLGYSAADLLNKHF
TELTFEEDKEAGLDDLQKLIRGDISSFAQEKRYYRQDSSTFWGNVTVSAATRPSGESDYL
IVVLEDISSRKQAETDLQHLNRELEERVSLSTLAFKASEQRYRMLFEFAPDLLFVLNMKG
EIQTVNTAVIQRLGYTKAELAGKSLPNCLVTGSPEMHAKDFESLLKHGTSRKEMEVLCRN
GSTLSVDCACSIIADTLGKAPYILVIQRDISDLVQAKAKLKASEELFRLAFEEAAIGMAL
VAPDGRWLQVNQAICDLVGYSAAELLDLDFQTITYPDDLGTDLSHVTKMLAGDITTYQME
KRYLHKQGHIVWVLLSVSLVRDHQAHPLCFISQIQDISTRKNLEMRLRGSEQQMRSVFEA
MHDLVLICTIQDNTITGIDIAPTTPKIEDDCSSDLASQTLEYLWDSAETVPGQKIQQVMA
TDTSVQFEYKLSMCGRERWYSANISPLAGQAILWVARDITALKQAEKDLFREKELAQVTL
ESIGDAVITTDTQGNIYHFNPVAEHLTGWKTSETQGRPLAEVFHLVHEETRQPAENPIQK
ALREDRVVGLANHTVLVARNGTEYAIEDSAAPIQDRDGQVIGAVMVFHDVTHSRNLTRQL
SWQASHDPLTGLANRRKFEQILLHALQVSQEEAQQHVLCFLDLDQFKVINDTCGHAAGDE
VLRQVSKLLQQAIRVTDVLARLGGDEFAILLHQCPLERATEIAENLRQAIQSFRFQWNNK
AFSIGASIGLVTIDQESADLESIVGAADAACYAAKAKGRNRIQVYQDDDATLLQQRGEQQ
WSVRIKQALEDDLFCLYGQAIVPTIENSGKQYFCEILLRMIDEQNRVVTAGEFIPAAERY
NLILEVDKWVISKFLNDFYPRLHMSKEQKAQPTQYMINLSGASVGDGQFLHFLKQQLGQH
PEAAQWICFEITETAIISNLGQAVSFMKEIKELGCSFALDDFGAGMSSFAYLKTLPVDYL
KIDGGFMDDLADDPATYAIVESINHIGHVMGLQTIAEFVSSVEIREKLQSISVNYVQGFD
IELPKALAV
>A0A1V5JXR4|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin520|TrEMBL
MVYRSRLDEYWTKVYVSDQFTALTGYPVEDFVDNRRFHMAQIAHPGDSLRVVPEVEECLA
RGRPYDVRFRIRAADGSWLWINDRGQQFRDSEDGSLWIDGIFTDITDLMASLERIQDSET
LHRMVFETSGTALAVWEGRGPLLRVNEEFCRLTGLERSQVEGRRTWESFFDADPFLPGGA
PRPQQPPRRYEGRLVDLQGVSHDVAVTVAPFPDGVRHVASLLDVTEARRTRRALEESERR
YREMADALPQTLFETDPSGHLIFTNRAGFEAFGFDEDDLRRGLSVFEVIAPEDLPRAREN
FGKNLGEQDVIPREYLARRKSGETFPVMVYSQAIRHEGVVEGIRGLVVDITDLKGMEEQL
RFLSMHDPLTGLYNRAFFDEEGARMASGRFDPLGVVVADLDGLKLVNDLLGHSAGDRLLR
DTGRLLKEAFRSSDVVARVGGDEFAAFLPECGEGFAQEARRRILAAVEHHNETQGGVPLS
LSVGCASGPGKSPGLTSLMEEADNLMYQQKRLQSPRSRARLLQRLLESFEQKTPDTSREE
ALIRTLLSQKSFPGADPLCGALLARYHDLGYVGLPGEIWRSASPLTEDEWRDMRRHPEIG
YRIALACDHLAPVAEAILGHHERHDGTGYPRGLKGEEILPINRLFAVVDAYNAMLSPRPG
RPARSSLEAAEELRRHAGSQFDPEAVAFFLEAFPELEDA
>A0A6G9RRS0|diguanylate cyclase|EC 2.7.7.65|Kluyvera genomosp. 3|TrEMBL
MTATTAASSGWWARLTRRVSPERVVNICFLVVLFFSTLLTWRETIVLEDAYISSQRNNLK
NVANDMDAQLQFNTDRLLFFRNGMESALQVPLAFEVLRTAEQEFERKRAFADWRISLNNN
RTLPLNGVSDNFVKHTNLLSRDNSLLGNEFMAAIELGYLLRLSAITRQHLSRFETHMLYV
SRAGFYLSTEQNQGNGITEYYYSLATSPWFIQQSQRDNPGRGVKWHTSFTRDKVPVAQMV
TASVPLDYDHYWFGVLAIQLSVNEMTQFLMQSVEGEEEGEYQLYDRRMNLIASSEEEPQK
RTQLSQEIQAQLAYAYEHDNEGSVRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDFGSI
SIALTLLWILFTSMLLISWAVIRRMVRNMSSLQDSLEWRAWHDMLTRLYNRAALFERAGK
ALAVSQQRGAPMSVIQLDLDHFKRINDQYGHQAGDRVLTHIGRVIINKIRKSDIAGRVGG
EEFCIVLPETSLEQAVVIAERIRESIYSREILISRNQTLRVSASLGVCSSEELQRYDFQH
LQSIADGRLYQAKQGGRNRVCAEG
>A0A1X9MER0|diguanylate cyclase|EC 2.7.7.65|Alkalihalobacillus krulwichiae|TrEMBL
MVLQSILANIAIILMMHLCLVLLMNNKEKFSKWTYALGGIFLVSFAVIAMFYLPIKYGHY
QFDMRMIPLVFYGYRKGWKYVIPVVVIVSLWRLGIGGEGALPGVIFGMVIPVGFALLVRN
KKKPVIGLSTLVFLVTACWLISDLPIIMILPDGWNVFSEIAIYRFLSFNLVALLLYFFIY
SSEKEIALKKQLQFLAERDPLTGLYNIRHFLSKVKALCGTEEKKYILMIDLDHFKKINDT
YGHLTGDDILKNVAELLDRTATSDADVDAIAGRYGGEEFIIFIKEKAPINIIEKVEAIRR
EIETATFYTHDKTELSVTVSIGVCRVKDASTIRETIERADCSLYESKKNGRNKIHFADKD
VG
>A0A7U9RIK1|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MQKTFIKYTFFILTTAVSLILGIHFLFGVHMLEEQQYDTFHAKIEQMIHTLESNREELQQ
LNESLDEDYLTRARAAEYVLDRMKSVSMDVSQMQYLANLLNVDELHVIDGNGIIVSASVS
KYVGIDMADHEQTREFLTILESDDENAFLIQDTQPNAAENKIMKYVGVARKGQKGVVQVG
FKPIRQMDAISRNTYSYIFSRFPTDIGEELYVIDQDGKVLGHSGGMENDFRAPCYQLEQL
KDCEEGIYKEGQNGKPMYVVGRQYDGVLLCAALPRSILLQKLWKNILAVSAYLLFIEAAV
LLLLNYLVKRKVIDGIHYIIENLTAITNGNFDTVVAVGGNREFEKLSAGINMMVKSIVNL
TDHISVIIENSGVPLAAFEYERGINYVFTTSGLSELLDLPPAKAAKIYQSSVLFDEYIQE
ITENPIEGEEDIYRLGDKKYARIHMSKSAKGCLGVITDVTKDVMEKKRMQYENTHDALTG
LYKFEYFKLLAEQMLQKMPPQKVCAAVMLDLDHFKSINDTYGHDGGDSYIQDFSNIMKSM
PPEHFLCARRSGDEFCMMIHDCEDKAAIVCHLDIFYRELGKNKTRLSETHFERIRASAGF
AWTDNPESSMTELLSHADEALYDMKNNTKGYYGEYTVKPGGVYNALERRQKHDK
>A0A7U9MQT7|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MSYNEVSFEKRLKENIKNYAIKNLYVMDMLAEYLQVLADTYGMELLLTDRHGETALAIGD
FEGFEPDVVNKPGEKIRVADRTVGHMYVKYDKVQDDKKESAGKMLEESMKLLTALANEVY
MHRESASYIDELESKLGQGNAQRKCGETEDILTGVYNKNYIKTRMQALEDSETVPVAVIN
VNINDWKFVYDNFGVEKSDSLIQVVASIVKKEAGAEYIIGRIDGDVFLVLIPLAEDGEAE
DYCRRVQAACQAYDEDEVLAPSVATGIVYRTNVEESLEEKMSDAEYEMFNNKLEIKNSPG
YQERLRRGLKG
>A0A2X1B2G8|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MFQSLTSRIAAVSALVVVALLVLVAALADASRQTRESFRWVTHSAQVIQAMEETVAGLRD
AESGQRAYVLTQNPAYAQSFDARISDSLRAFSELVELTRDNPSQQLRVQALGAQLSGRIE
LMRQPLTLARSGDFAKAEALIAEGRGFDSMSAFVLAARELLDEERVVQSRRVEAAEGRLA
RVRGLALIGGPLIAFFSLSVSFMVIRGIRQPVRVITRAMTGLGAGDLNQRIDSRMGSREF
DRLARGYNDMADRLATAAKDQSRSERELKRVHEELLASAQTLRERGEVIELLGGMAHRMQ
AARTDDELAQVIHAFVPRVLPGLPGALYAYNNSRNLLVPLSGWGGHEAETEGFAPDQCWA
LRRGQSHLVSEPGADVVCGHVNPLAAPYHCEPLLASGEVIGVLHLDGLVEAETQFRLNVL
AENIASAMVNQKLQRDLKEQTIRDPLTGLFNRRYMEEALALEVARAARSGAPLCVVMCDV
DHFKRFNDEFGHEAGDVVLQAVAAELGHRFRDGDIVCRYGGEEFIVIAPGTKAETLAPRV
ETVRQAIAAIALRLGKQPLGSSTMSFGVAEWSKGMNRDGDALVQAADAALYRAKKEGRNR
VVLHVEETA
>A0A098G7K9|diguanylate cyclase|EC 2.7.7.65|Legionella fallonii LLAP-10|TrEMBL
MPNKSDWLLKFITYGVGCITVFLGMAVIIGWHWHLLFIVQISPDWIAMQYNTAICFILGG
LSLIALNTSAIKISRVLTFSLLILSGLTALQYFLNHDLGLDRLFIRLFFTTLVHHPGRMA
LNTSLSFLFIGLILLWFTNPYAVSEKKAEVSINLIIIGFILILLVNLIAAFTMHYGIPNS
MKMSFSTQLGFFILSLGLISLTYQNRMGEKRSFIAPILVIFVFLVISLCGWQSLVKSQYD
YLNKLLQLKTQSISDYLSVTMQERASSFLRMSYRWMTQNNTLENAWRADATHYIKDQPGY
VAIAWADKDYIVRWIVPETGNERMKDFNLMRDPKSRLVIEKSLAQRQLQMSHLVNFIKGD
RGIMLLSPLFKKEQFDGLIIGAINTQIMMSHLLHSSLMNDYELKIYSDGQLLYDSENKDF
DLHKNWTKRMELLLLGQTWQIELWPSDQLLQQIMGSWLPLGTLLVGIFIALLAGLLIRVL
QQVRDHSAKLNDISFELADTNERLNGILEGSTDLIAAMDLNYNFIAFNNAYKEEIYKLLK
VNLQKGMNFSVLMEKMTPENREKSFSLWQKALQGQPFTVIESFDDKRFSDLDFEIHFNPI
CNARGELVGASHTTTNIFYRLQNEKRLRASKKELEQMVLNLEKLNRELGFLEELMSVLQS
SDSRDEMIRPISTFIKMILSPTSGVIYFIDSDNGNMLKETYCWGSPISHQTEIMKSDCWA
LLRGKMHQVARNEKLVVCEHVGADLEQIAVCICHPLYAQGLMFGLIYMEIDVEEESLSNR
LIYLFQILAEQISLTLYNINLREELRLQITHDALTGLYNRRFFEEYLEKELLTAERTSSS
FSIVLVDIDHFKRINDKYGHVVGDKVLQSVGLELHNQCRKSDVICRWQGKEFLLFLRESS
LDDAASKAELMRQSIENLIIETDGERMAEITISIGIAVYPLDGKDLDDLIIHINEALYMA
KKQGGNRVSICGEKAKKRKRGGA
>A0A128F7T7|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MARGSTAWAAVVTLIFFLASFAGTTPFNLHDANIAQVSIASGIGMIGCLYGGIRTLLALI
FASTLAFGLAIYSWDPTAPLIPALVTGAVMPLACYLSAQIWKNLFSNGGVRFETLKHYVL
QVCILPGFLVSLVAASDSLYGSYTGKGGYFYDLYELTSTYALGILLVAPFYQLWRLEEDP
FRQFSRNAILSIVLYLTLTILAFIAGAPGLIFVAPVIPLILAFKGEELASLAALFGMGII
VTTIAPYNLGPFDLPNKVQGHASLLTYVLMSVITPLAIGLHVRRLNVVSRSRDKWQSKAR
TDQLTGLPNRYAFFPELAKQFEHASKQGKKLVVAMIDVDHFKMVNDTYGHAFGDVVLMDI
ALLMQEEMRDSDLLARVGGEEFAILFPGTNEDQAFKALERLRTRCESHISRYQDVELSIT
ISIGAAVFKSPEPKDSLLGRADSLLYQAKEDGRNRTIIS
>A0A128EUA5|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MLKRFTINQLLFVSHLMLVIILIAGMSYSRYQSEWESRVNHEAALIEQSVLPLMREISAA
VAGRNYTALTMPSHKDTLRSIESLLLLDVEGTSDYQDKKVCVRYFRETGDIWRIDVSDEE
LEQSRLNRDNLASQVDADGLSDVTKRKLAFLLKKAEEDLAALELGKARTQEFAAPWPLRP
NSAKYELLPEYGVVAVQLPLYNKNGGMVYAVFDASRLFSLKNEIYLTIAIEASVALLISL
LLIVGVTHWLVAPLRRLAEQMDKDIEKLNIADMDEVNRNDEIGVLARGLHRLTRKTQSQL
KQLKHLSDTDALTGLSGRHNYEDRAVALYKATQRQGAYFGAIVCDIDFFKRYNDTFGHGK
GDEVIKKIADVLLSNTRNNDLCFRIGGEEFVVLLKVYEAENLQYIAERMRSEVEALAIPH
VTERGIVTLSIGAVMVPPQAKAWTYPDIFDFADKQLYAAKHGGRNRTIFKEIGRDELPPE
REHCNDTSIEAVD
>A0A2G2KKJ1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAVETLIEHHSQNFADHFYRVMQEDPHASLFLSNA
QVEQRLHPSMQRWLKAMFAVEHADFESLVEQQEKVGQVHARIEIPVNLVLNGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQDIATLPRLSNSDFGLWYLHKACHAFEGAPEIATIS
RHIKQVDCEWLEVLLHEDPSQRLKALGEIRDAARTVLMLLDDVLQRASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTXSVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A6I6B3K5|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. MSR2|TrEMBL
MQEEIKQYISVILKEWQPLRAELPQNVIVILRNIAEEQSDNLAHRFYESLFKDPAIARHL
SYELVEEQLSRSLSKWVKAILTQDESQFETLAQQQYHVGGVHARIGIPVEFVQRGARQLK
YGIYDYITQHNIETELGLQVMHYAAMAIDIAIEMMSHAYAMSHYRATRNEEAYRMHVLMN
NAWQEQGKQQSALSSWENSVIYGLVSGVHQSEALIKISDSNFGLWFRHKCVRQFGETEQI
QQIRLLMTTIDQKMASLDITTDIPVEKLQDLLRIIHACCQKISTYMEMLFNDVSHMQDGK
DALTNLLNKRYLPIVLKHEVSLAMENHLPLSVAIIDVDFFKKVNDEWGHTVGDRALTHVA
NLLSDNIRASDYVFRYGGEEFLIVLVEAGQSEAYMLLERIRRIVSSTPFEAVSGKNLPIT
VSIGYTVHDGHPDYNQLLNRADVALYEAKRNGRNRIEQHK
>A0A6I6AVY1|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. MSR2|TrEMBL
MAQTPLPRQSGNPILSVHLCFFAVFLFSAFLTVHEALELKTSYEDRQRAQLAEIQKNLDS
QFQESVDELVYYQKMLSYALTHPLDSDNAREAVTRFQALRQHPLWQLQLNSPRSMPLNGV
GDAWLARDPLLRRDPALIDQEIRAALEFSFIMQFSDPDHDFHSRFWYISRAGFYISSRPP
QSPQELEQSYATMVQRAYFRALNPQQNPSPYLRWTSGYQGQFDEGLMLTLSAPIISNGYW
YGVLSMDFPQARIRNLLAETRHTLLQGNLVFLDRKLEEVARLHAPDEVPLNAEQRQELLK
RMQHERSGILRLGTQFASWSKLENVDGYIINVQTLKQGMKQELGRVTLFLLGMWLLFVLM
LAVAHQVIFRLVRRQDELSARLTWRANYDGLTRLLNRSAFFEQFVAQAAHCQQLQRPLAV
IQLDVDHFKKVNDTWGHHAGDQALIRVASVISHTLRKYDVAGRIGGEEFCIVLPETTLAE
ASVVAERIRARLAAKTILVNASTTFNITLSAGVTSSEEQGDYDAESLQAKADSRLYLAKT
SGRNRVCSAD
>A0A376EN51|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MRPGIAPDGNAYADYVVMIKKKNKQELAATPHPLLRLVSLGLLTYIFTLFSLELTLFDTL
LAPLWFPTSIMMVAFFRHALRLWVPIALVCGAGTVLATLTLFPPAHLELSYTAINIIEAL
VGAILLRKLLPWYNPLKNLNNWMRLAFASAVVPPLVGGFLLVAISDGHVTLRLALVWILS
ETIGALALVPLGLLFKARYLLRHRSPRLLAESLATLCVTLLCSWLALHYMPWPFTFVIVL
LMWSAIRLPRLEAFTVFLATVMMVSFVIATNPTLLDLPHEGVVVNAPWLPFLMILLPANV
MTMVMYASREERKLITESETRFRNAMEYSAIGMALVSTEGGFLQVNKALCTFLGYTPEQL
ANMSFQQLTYPEDLHADMAQVEKLLNGEMNNYSMEKRYYTRAGDVVWALLAVSIVRQRDG
SPLYFIAQVEDITELKRTEWVNKRLMERITLANEAGGIGIWEWELGTDVLAWDQRMFELY
EVPPHTRPTYQLWKSRLLKEDVAQAEATIQEALRARVPFKMEYRIQVKNGVRHIRALANR
VLNKQGEVERLLGVNMDMTEVKQLNEALFQEKERLHITLDSIGEAVICTDIDMNVTFMNP
VAEKMSGWRQEEAIGQPVLGILRITFGDNGPLLDNIHSGEATHPGTGIEQDVVLHCRNGG
NYDIHYTITPLSTLEGENIGSVLVIHDVTESRKMLRQLSYSASHDALTHLANRVSFETHL
KRLLQSVSETHQRHALVYIDLDRFKAVNDTAGHAAGDALLRELASLMLGMLRTTDVLARL
GGDEFGLLLPDCSLENARTICERIVAAINEYPFVWESRLHRIGASAGITIIEASNNQAQE
VMSQADIACYTSKNAGRGVVTVYEPHQQQLHHGRGTLTAQEQQRMISEHHHVLMVRPVAS
PRVPESASFWLLSLRLWTSEGEMIEEHSFRAGLNDPELMQALDTRMLTDFFRDHAANVAR
KGVGVALTLSGATLLNAQRLDALLAQLAESPLPPRLLHLMINSEVLMQDAATARRHLARL
REAGCRVVLSHIGRELEVFEHISAACADYIMVASDLVTDAHASLMDEMLLTIVMGNARRL
GLQTIAGPADQQSLLETLASVGIDLIYGETVSQTQALTARLATSYFAIH
>A0A8F9HED5|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A375CKT2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MVAFSLSVMLLLLLLWRGLQLSQGREIESLRHMQAVRAQSMDALLQREAERLLSVRNVAQ
HLLQIQATAPGALDADLRATLAHRDQPVWPVPAHDAAAVYGISAAALGGLDGFTRDEAGL
AADVIVARSLSHLLSAAPEGSGIRRRIAYVSRNGVLAAHPSIPQQEVVSAVRRLAAAPYF
SDSLPSRNPGRRVQWRIAPATVEREQLSLFLSVPVYAEGDFRGVAMLELPQRSLDDQLSR
APFHQANSYLIDREGRLIGASTRNVRAGETMQTALSGPWPAATLDAVFHADSGLLDGAGG
ASGSDLMFRRLRQGGLALVDEIPLHQLWLAGAARLSGVIGAGAAALGILLCATLAVVHSL
FRHYLARGEALRTLAETDALTGLANRRVFAARFAADSARCAAEQRPVSVVMLDIDHFKSI
NDRWGHASGDVVLRAVADALRGGVRKDDLPARLGGEEFAVLLPDTGVDDAAAVAEHLRQR
LEALRCEPAPDAGSTGPIRFTASFGVAAIAPGNGGNLDALLMAADRRLYEAKANGRNQVV
AR
>A0A2U3LXL0|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MLDKSTPKDTPRFNIQPWLSGTTVTVILILIQGIPYLWLRVVGVTLVVVALFLVIQKLSV
ERRRLLSFITIDELTRVGNYRAYQERMRLEMQRSQRKHDPLTLILIDLDRFKNYNDSLGH
RLGNELLYSAGQTFQDAVRSTDGVYRLGGDEFAIVLPETDMEAARHIVKRIQLSFGCLPN
RAEVTLSMGMAIYAEEPLNDFFDRVDHLLYDIKANGGNGCQFERKLC
>A0A6N3QWU6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAILASIKPAGVVSRADVVL
PNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANPQPIAYLVLQADSFRMY
KFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIARELNAIPAQELVGHQLALP
RLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNKALLMEMLEQVVARKQT
TALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMILAQISGYDFAVIANGVQ
EPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTAEQLYSRAISAAFTARH
KGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQVEMTSGKLVSAEVLLRI
QQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQERGIMLPLSVNLSALQLM
HPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRPLRNAGVRVALDDFGMG
YAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQSLNLQMIAEGVETEAQR
DWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>K9NN76|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MTHNAIQRLLLKRFALAAGTYALVLLLLWLAFFTGHYEAPLASVAIGSALVVTSQAVLFA
VFYSGCNLRFADPSLTEAQVLLGLGWQTWLIAHLDEARGAFLVFYVLILLFGLFHLSRRS
FVRCALLVFFSFSAITLWEGYHFQLPDPAMAVLQVCVLFIVLVWLVLYARYVQASRQRMR
QRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLASRELNAMEAGVVHGLALI
DLDHFKRINDLHGHAAGDQVLQAFAGVATACLRDSDVLARYGGEEFVVLLPDCDADSLTS
CCERLRIAFTDVELIGLNVRNLSLSAGMTLLELGDDLDDALQRADQALYRAKRDGRNRCA
AAWENVDA
>K9NHC4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MKPPSQTNAIDFDSAKLQRLGFGQQPPLLERPVCLAQMRQQLGLQLQTSLEPQRILGTFY
REIQRLVPLDALCYLHKSSDLRLEFGQRGHHSISYSLSHDGEHLGELIFRRNQRFSEQEQ
GNLESLLATLLFPMRNALLYRTATQSALRDPLTGTGNRIAMDQTLQREIELSRRHLQPLS
VLMLDIDHFKLVNDTHGHSTGDHVLKAVAASIKNQLRNVDMVFRYGGEEFLILLSNTSRE
AAAMVGERLRFAVQAEEYLADGHTILLTVSLGCSTLLPGESADSLLRRADSALYVAKREG
RNRLEMAG
>A0A5U9I3K5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
MRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A378JDH7|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MDFPGITRIQIENKLIAESYKNFYVLIIADFFATLLFVALVWSQVNNKLLVIIWILLMFV
FNHVLRSLFLFHYYRRKKQNSLFHPTFWKNYFIVNNLQSGILWALGGSLFLYIDNPLHRM
AIFVYLIGLLGAPAAKLLMMHSAYIAFMMPIWLLLIFLSISITPSLSFILLMAVLLYVVI
VIYGTRDANQFLMKSIYLELYSSNLLSDLRRSEESFRNTIENAPIGMAIVSPEGKFIHAN
RILQETLGYTDEELLNKNMIAITYPDDISMTQDAVNKLLQGELRISHMEKRYIRKDGSII
WGMVSSSLIRDEQGDPINFIIQMKDVSDRIQNEEKMRQLNKKTVETLNELKLLEHDESLL
NKLNRSLQICITTEEAYPRINLIAQDLFPDLSGGLSIYNKTIKQMETVVEWGKELLLPKI
FLPIDCFSIREATTNIVDDPNKSVPCAHYKTPPQGGYMALPLMVQNELIGVIHLLAPKDK
RLTTHQQEIAHSFGNIVKLAIANINLRVSLSELSLHDPLTNLYNRRYLNDILSRELIRIA
REKKTLCVAMLDIDNFKKFNDTYSHLAGDELLKAIGKLLNDSFRESDVSVRFGGEEFVVV
LLNTTLNNAVIKMEELREKIKNISIYFKGNLLNNITISIGVAEALKHGASIEEIIKAADH
ALYAAKQAGKDNVKAYSHNT
>A0A8I1XM01|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MFPVVLCMQIPDAPALNLTHATLLPGGVNAMIGARLPANEDERVQALHAYRLLDTAPEPS
YDAFTAIAAAVCRMPMALISLVDTHRQWFKSRLGMQHSETPRELSFCAHAILQADQVMEV
GDTHLDERFVRNALVTGEPQIRFYAGAPLLTPDGIALGTLCVLDRVPRRLSVTERDALQA
LSKQVVSTIELQQAARLVELDALRDALTGQWNRAGLERALHALADAPSAAADAPLGFMLL
ELDGFKRQKLQAGAAAADATLLQVATLLETQLPPAAIVARLACDQVCVALPATAASAAFA
TAEDLRKAVEDAHWPTGPLTLSAGVVEVATPTALDSNTLLARARHALQQARGDGRNRVHR
FDGWQLRA
>A0A2S6UEN3|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha4_Bin1|TrEMBL
MDGREQATAYAEAALENMARHGVPRTPSNFEVWYTHASGRDIDLSKALDILVSNDQPFTD
EQNTDIYQRYFNLADTSAAVYATAQEYENSMDTVLDLLAQANNDVEYYGKALEENLGSMG
SAKDFKVLRRALETLVSDTKEMAAQNSLLKNRLQVSTTEIKSLRTNMEDLQKEVMTDALT
GIANRKHFDILLRQMAAQAMEDGDDLCVAFGDIDHFKNFNDNFGHQIGDQVLKLVGMILT
ELSEGGTMPARYGGEEFAIILPGIGLDEATEVAEKIRTTVASKRIRKVSTGDDFGTITMS
IGVTQFRSGEPLGDLIHRADLGLYHAKHSGRNCVVTERELDQAALET
>A0A399F999|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MIAAACRSTAPEEQSPLYRFKRMVLWVSLPLGIVAALVGWVANGFGQSGGLYDRLSLPVF
ALSLAVYVLLLSCGGQNGLRRAEVGVFWSTALLMLLNLYFNFLVVAKEGVWLTAVWMGLV
FLLAHYVYEPGVALRVSAGLFVALLIAGGAALWPQVVTGAWSDPNVVVQIYGSQLIYLLL
TRLLVAYREQADRLRLQAEALHHLAYTDSLTGLANRRSVREALAAELARGSSQGPLALIL
LDLDRFKQINDRYGHEVGDRVLVHVAGLLQTHSRRGDLVGRWGGEEFVLLLPGGSLAEAQ
GLAERLQAVLSQNPLEGRYPLSASFGVAIAHAHDTPDSLISRADNAMYASKEAGGNRVEV
AIAG
>A0A447M2R5|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MQSAVTQFEQRRGSRFWQLELDKRRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLEL
GYLARLAQSSAMLTRETVYVSRSGFYLSTLPTIYGSDIISRYYQYVTQPWFTAQSQRRNP
QRGVQWFTSAQPYFDEPEKVTASLPLDHAHYWYGVLAMDIPVASLQQFLRDATEKDSEGE
YQLYDNHLHLLASSTPEQHTEALNERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDG
VLLRVHTLREGVQGNFGSISIALALLWVLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAW
HDPLTRLYNRGALFEKARRLAQRYRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHA
GGLIGSTIRSHDIAGRVGGEEFCIVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRI
SASLGISSSEEYGDYDFEQLQSLADKRLYYAKQAGRNRICASDVAQEREKK
>A0A837FJJ9|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei subsp. xiangfangensis|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARFGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A8G0SYU7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MLCWMGWERFDHEAVLIWMSVLTATTLLRTEMFITYRRAAPNQRSPQQWERRYWLTLALS
AGTWGLGALAVMPVGDLVGQTLIMLFAVGMSVSAVSCYSSFRNMTLVSVALVLLPCTIWL
LLQPSALQQGIALAVLVFASFVVNATRSLSSALETAWRLKHEMEHAHRLAMIASCTDGLT
GLNNRRAFFDHASAQHALCEQQSGLVAVLMLDIDFFKQINDTFGHAAGDRVLQRIGTVIS
ACLRDDDIAGRLGGEEFALLLPNTPQAEAVEIAERLRALIAQLNVSSEHGVTASIGLVYA
TTADSDLDALLVCADKAMYRAKASGRNRVELVEHVRTTA
>A0A1V5UIF7|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin239|TrEMBL
MCCRNVHVNFTSVEEKRDCYKKMEIVLKLDVKTMIGVLICGNLVLAFLTLRYYLYNESDH
EKNLIRRFGIAKILQAIAWLFLFFRGNISDIFSIYFGNILLFISFYLDSLIVLHLNKKPE
KIWFILQTILLAIAIILFVVFELIFDSGNIRVGIASLGIFCIFVIPNLLSIANKLSTRFE
KFISFISLVFLLLLLMRALNSLFDSNVSLFTNNFFQIGTFLALVLLMLVNGTGFLLVIYD
RSYELLRASSNLDPLTRIYNRRFFMNKAESHYQRALKDQSSLTFLFLDIDFFKKVNDTYG
HLFGDEVLKVVAKVLSENIRPVDLCCRYGGEEFLIYLHETNKEEAISVANRIREKIQNLV
FADNQEYKCTISVGIYSAQPDSTKNLQFFIDNADQALYMAKEAGRNCVVSL
>A0A560CJK4|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALAEAEAISGVFYTILLDRPDSNSFL
SHTLVQERLRPSLARWIAALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSTRLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISAKVSAAVEGGWITPAFVKELNNDVTEIAYILGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRTVEEHRFHGAGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A0C7QPV9|diguanylate cyclase|EC 2.7.7.65|Paeniclostridium sordellii|TrEMBL
MNNNLMDLIFDTLPFPMWIKNEDGVFLKINKKFKNTFIDRELTQDDIIGKINKDIFEEDL
AKEYDENHKKVVELKQPMVFEGKTRNKSVMSYLTPILDENENIIVITGVIKDTTETKNYQ
QSLINQNTLLETIINTIPDIIFYKDKQSRYLGGNKAFFKGFFGKKKSEVIGKNDFELHQD
KEVAKAFIERDQEILKNKEDKYTEINILNKDDKILYLESVKTPLINEKGEAWGIVGVARD
MTKRKELEDMLTQMSYTDKLTGLYNRAYFEEQINKLDDNEYYPLTLIMGDLNGLKAVNDN
LGHLEGDKLLVEIAKVLKGSCRKEDLVFRWGGDEFIILLPNSDYKLGKEICNRIQLNCKN
TDKTPIPLSISLGVSTKINKQKDIDEILKEAEDMMYIEKLKTKIN
>A0A518DEU3|diguanylate cyclase|EC 2.7.7.65|Pirellulimonas nuda|TrEMBL
MNHDDQQRLSALEALAAISSDLVAVSCVHPPARLIASTPGFDAWMAQRGVGLEVLLKSTA
SDGPDPLESDGWRLETRAVDGDPSLRAIRVVSADASGVIPPPTIDSVSGVAARASLDQQI
SRWFARAGASPFALVFVDINAFKAVNDHHGHLAGDDCLRQIATQLTESVRDSDFVGRYGG
DEFVVLLAGVTTAQELHPLVDRLRKAVSASETASDGESQVAASVGAALSSEGYGSARDLL
AAADRRMYDEKRGSRPR
>A0A2X3J9C6|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MAKTASAEKCFAAKNGPFRIHSLAWQTGAAFRTALDKLIDDTASLHDSALLFMDGDNFKF
INDTWGHAAGDAVLIEIAKRLLVFANTRHLAFRLGGDEFAMLLHSVNNEEQASFVLTQLK
EIVEQPILLPGEHWVTMTLSIGVALAKDITSAESLMETADRNMYIEKHKQRELLIKQPQR
DTL
>A0A8E9YNS5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Inverness|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVVSLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0H3BWM7|diguanylate cyclase|EC 2.7.7.65|Salmonella newport (strain SL254)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A701UCK9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 47:b:1,5|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A1A8SZC6|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MPRRSAVQFILTKVVACYIAMAVVLLGGLIIWSYQQVVAHRADMTAQLQTSVVEAITQAP
GNEQQALQWLTLGIQLSESDSVAFQSIALLGEDGHVVFAWPSSVELAATASSAFNLLDLQ
NSSFTLAVTYSDTLLEHVFKHDLLPVIALLVGQLMVLMLLLNYLVKRGIYRTFSSFMREL
SMVNLRQPAALQADSFLGQFKEYRQVLVGVNRVILSLAKSREQLAESNQGLERHIHAKTA
ALEERNEELLILNKQLSIIANTDSLTQVYNRTRFDVLFKEHVTLSKRRATPLAILLVDLD
DFKKVNDRFGHQTGDHVLKHAAHVIQREIGAEGVVARWGGEEFAVLLPYFDLAKAEEQAE
TLRAAIAKARFEEQAIKITTSIGVAQLGEQETAGQLLKRADDALYDAKGLGRNRVIIASL
EQSHTQLELADGEFIEVLDVASEPTQGEPEVSEKLPT
>A0A0A2V7K5|diguanylate cyclase|EC 2.7.7.65|Beauveria bassiana D1-5|TrEMBL
MGKLAAKKTAGVLGDDLSLNAQQVSGLRANRELPVVWSVAKGSFLNKLILVPLALVISAF
APWAITPLLMVGGAFLCFEGVEKVLHSVKASRHKESAEEKQARLEAIAAQDPLAFEKDKV
KGAVRTDFILSAEIVAITLGIVAEAPLLNQVLILAGIAILVTIGVYGLVGMIVKIDDLGY
WLADKRAALAKAVGKGLLILAPWLMKALTVVGTLAMFLVGGGILVHGVPVLHHGIEQWVG
QYGGAVALIGPTLANLVLGFIAGGIVLFSPLMPEAAMVYVVSDEVRRKNGGPRMIVTGYS
SGMVECRWYDGYGVKREAFREDDLAPVEIREHQQRNSLDNIATALDRQLQHSIDNLLFYR
NTMHYALQSPISTDISRQALADFSVQRTQPYWQLRLDLNRGMPINGVSDEFVSHGHVLDR
DESWLYPELEAALEFSYIMQLADDKRDLQRRVFYASRAGFFLSSTPPENDPTIVSLYYRL
IAQPYFGAQSPENNPGRGLQWTHTYNPSSLNGQIITASVPLDLNQRWYGVLAMDFPVSGM
HEFLQGLSHDRYEGTVMLFDRQFSLIATAANSLPLSPVFNAKQQAEIARSMESGEEGELR
MDSRFVTWAKLMNFDGVLIKVHTLSEGVQGEFGRISIVLTVLWLLFTLMLFISWRIIRRL
VSNMLTLQQTLSWRANYDTLTRLYNRGAFFDIAHGLAQDCQREDKPFSVIQMDLDFFKGI
NDRFGHHAGDKVLSHAAALLASSLREGDVAGRVGGEEFCVLLPGTRLPEAAAIAERIRLR
INTKELFLQAGQTLKISASFGVSCAHERHDYDFEHLQSIADRRLYKAKQHGRNQVCMQD
>A0A6H3ARS4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. A316|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLDKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADESSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDARLTTTLSPHHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A1R7QED6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQYSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAGLPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A3S4EN25|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MFAATLPILVNIFVAGMFVASFLTIAQLNPGFANIRWIALSYAFGLLTPLAELLLPLSPW
PAPFMIVSYGGMLIGLVLMAPALSLLYSRQPYWGWAFGIIASGIALRVLIWGGQRNEFWY
ELLYQLPYAAAAFLCAATILRHGRKTGLDTAAASLFAVIGVHFLLKPPAAVYFGSGASAL
DYSKTTYALISQASSGVLLIGAGLLVLVNALQMVVLRDRNDAMSDPLTGLLNRRGLHAAF
QKLTAQRSGLSATIAILDIDHFKAINDAFGHAIGDEVLRSVAECLEGNRPANATIARIGG
EEFVLLTPWQEESLARLACESLRMAVRQLSLRKVDSVAVSIGFTPVAPGEDLSQALARAD
RALYAAKAGGRDRCVFEPLDGSLQSGRATLRLVQ
>A0A0N8TYZ5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MVRVVSCIFLLLSFSVFADSARLSLSDYFTETWSTRAGLPHNSINGVTQTKDGYIWIATW
EGLARFNGREFKLFTRTEIPGLPDSGLRSLIPMENGDLYIVGARGGIALRSQGGWRALPS
SSAMVNHALVTEQGELWLALEGQGIVYRASETATEQKLLDKLSAYRLLQDKTGVIWAATS
DGLYQIKNKQVSKVSEDSGLPNASVFTLLLTHSGTLIVGTEKGAWQKQNDKFVAINPVLN
NESIASLLEDAQGDLWFGTINKGVFRLSSLGLENLAADDGLPNNRILSLLQDREKSIWVG
TNAGLFRLREAPFTNWSQSRGLASDYVRTVLSHSDGSLWVGSSNGLNRIENGKLTTLIQA
YEKDPLSVLSLTEDKQGGVWVGTYTAGLMKVVNGQIYPVKNRSNGLISNEVRAVFFDKAD
NLWIGTAGGLTKIDPAGQTELFTTEDGLIGDFIMALVEDDHGRLWVGTGVGVSIYDPATK
QFKTLEFPKQFSTEYAFGFYLDGDKMWLATDRGLVRYNLSTDKMSLFGRDQGLPVDKLFQ
VIEQGDSLWLTSNRGVIQVNKAQLVALLDNPEKVQPMSVSMQLYDEGDGMLSAQANGGSN
PAAVLHSDGQVWVATAKGVAIATPERLKEASKRRLSTVIESFEVDGKPMTLPVGNEVLSL
PAGVSRVSFNYAGLSFIMPGRLNYQTQLSGYNQQWVDRGRLAITEYTNLPPGKYTFKVRA
GYPNSDWQNNEQVLRFKIAPYFWQKTSFKLFVLVAVLFAAYAIYKYRLYHYKRIEIELTE
KVEQQMHDLQTQADAFAHLANHDQVTQLPNRRAFDMWLSENFSQFQRDNKTLSIAIMDID
HFKLINDNFSHLIGDKVICEIARLLRMNFPDEGYAARWGGEEFTLLFPYKNAEEAARLCE
IIRLEIAGYDFSELADSLSVTVSFGVADNAQVADYDRLLSHADNALYNAKNNGRNQIFIY
NQGCITLD
>A0A0P9G4J1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MENVHVLTRQTDSNGDYLPYGQIYSEQNDISHTHALVTQLQKTLELTKLLNIFSVEASRV
VQFAGLQFHSTEGVIEMTGSKIEGENHAFDLMADGERLGQLIYFSQNLPQYAKQKLARLH
TALVYPLRNALLFSRVKKLATKDALTGLNNRSMFDDCLYRKLERSRRHHRSFGLMLLDLD
NFKQVNDQHGHQVGDQVLIDFANILTDCVRGTDTVFRFGGDEFAILIDDDNFEVSHILAN
RIKKRVHSHQLLKTHSVTTSIGFSLSKAKDIPNSIFERADRALYAAKQDGRDCCKTN
>A0A2I2MF06|diguanylate cyclase|EC 2.7.7.65|Leptospirillum ferriphilum|TrEMBL
MQTSEEPKARAKSALYKLLELSLPPTPENFTRYFYEKDLPSMEDLFRKLLGLTICLAETS
NTPSLSRDLKTIQSILDSGEVALTSHPRIESLLNQMLEARTEERARLQEKSRSREQLLSP
AEPGILEHDAGKEPFPGRKRPLYSHRLSDPEDAPDPGRKFYDTRSRPGPAPERVASTLED
LSREALKLQSQMDHIRNLVQSMENRMGTLQKHNRKVSREANIDPLTGILNRRGLQHRLSF
LKDPVLSLLIFDLDDFKAINDTYGHNAGDEVLRKIAQGVRTLVRKVDLFSRFGGDEFIVV
MPALEISQARFVAERIRSTIARMPVLLGTGSVTITASFGLTGTYVDGAQKMDDLLELADS
ALYQAKSQGKNQICATNPIP
>A0A1C3IZF0|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MLQTRYTSSTTYGDKLYLSALLYQYMSQRDQPFYGIASNDSDYQAIEQAFINALVNDGQG
QYKEAQQGFLSILVKMQSINDVTGRALLKYQLCRSLNEQAKYHQANYYCSALQSDLHDIA
DPVLPKFGTYRVIANNHHFRSDYQAALDTYLSLISVFPQGHDISGIYNDVGNLLKELKQY
DKSAEYLIEALALRSDASDLMKAQVHHSLADLYLNQGQSDLAINHFQKAKALLTTSSHSY
GIALTTLGLGKAYTQTKNYDLARDYLVESLSASSKLNNDVIRINAFLAISDMFEDQKLKT
EALNYAQQALELSEQVTRHKYTAQALLQLSDIHQTLSDYQQAFYFYQRYSLIQFETRDID
NRLAFEALDLAHARYEKELESSFLRHQANLDRLQIEKMEHQRMVYNIIVILLLCAASFMI
FTNKAIRAKAAIDAMTKAYSRTEIIRRVKRIKACKGTEKQHVLVLLDLDKFKKINDQYGH
PTGDRALVHISQQIRQHLIKGELFGRLGGEEFLIMLTDTKPAEVQERVEELHYAISSAVF
LSESKKPLNVTASFAYLATSNALSDFDDLYSVLDQALYQAKSNGRNCIIDAYNEPIDS
>A0A367PQ75|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator|TrEMBL
MTPDTAPPSHQAANDHPAPPRRWLPLLLAGAGYFVLAAAALWLARLPGTVAAVWLPNAFG
LGLLLHRPRAEGPWLLAGMLGASVLANYAAGDSVATALMLTGANLAEMLFALGLLRQLDR
HAVLRRHGPLAAFAVMLAVGGILAPALGATAGATAIATTHGTSFASVWWTWWQADALGMA
LLLPMMLSMTAVRVRAAIARPLLPPQAGALALCLAIGAVAQWQGHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLCLQALMLLAHRHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
SSDKRFRQAMEHSAIGMALVSMDGRWQTVNRAMTELLGYSAAELRELSYQQLTHPDDLTG
DLLQVDNLLSGQIESYRLEKRYRHKDGHYRWVLLAVSLVRDEQTGEQHFITQVEDVHARK
LAQQELERLSRRIQLAAEAGGVGIWEWDFTSAGITWDARMHALHGTDPAGGTPVVEQWIA
MLHPDDVSRVSGEMRQAIRGEAPFDTEYRIARPGGNVRHVRAMAMVTRTDDGTAQALVGT
NWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDATMHVTFMNPIAEQLTGWTMASAT
GLPLEQVFRIVDEATGDPIPSPVEACLRTLAPAYLQDGAVLQSLTGERHDVQDSAAPVLT
ARGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGHR
AALCFIDLDRFKIVNDTAGHGAGDVLLRELGYMIRNHVRPDDVLARLGGDEFALLLKDCT
VDQAEQVCQDVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAAK
AAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPEENEDGAEH
RHIEILVRMVDEHGELIMPGAFIPAAERYDLMGHVDRWVIRNVLRGYGERLGAVPGLSVS
INLSANSLGEPFLLPFLHAELEVSALPASRIRLEITETALINNMAAANRLVAEMRRAGCT
VSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVRTVA
EWVEDERTLDALRAIGVDYAQGYVIGRPVALDVFLAGCQQRDMQAS
>A0A8B5QI52|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls712|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLMWMLLPKETTLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKNISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVYMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPSSVIKTNPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKFHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A859TV85|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRALTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCMV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADISRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESSRFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNHVATEVMSQADIACYAAKNSGRGRV
CVYESQQSQMHAARGIPSPEEQRNIITHNPMLMIAHGVASPRIPESFSFWLVSLRLWSSE
GDIIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASGVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPGEVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A5I9F2J2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Glostrup|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7D6YYV7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHFPVTRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKHQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISRFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGNRHSPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKNLRSERTIIK
>I4F200|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MDEDTTGSRLPPHVGLLALLHGAGGLLCAVGALWPMSPDTPVGLAWVLAGVGLTVAALLV
TAGERLPAPAQQAALALFSLLLGLLAARSATAEGVIGLGPVLLCTGLYAAHFLPLPAARA
QVLLAVGAATAGALAARPSGFLLPWSIAVITALVVTESHGRLIGRLRTQASVDPLTGVAN
RRAWEAEATRDLARAARTGEPLTVAILDLDGFKEVNDRDGHGAGDRLLRQVATAWRTRLR
TSDLLGRYGGDEFVLCLPGTDARTAVDVLQRLDGGLPVGWSVGTATADRGDSLTELLQRA
DVRLYEGKRARRSR
>A0A6D1RGR3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVTMFRCVVSLDVTQPDIMGENSHCVCRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHPWHFDSFQDALLAFTSSVMEY
KIYLLNIRSNIDVLTGLPGRRMLDESFERQLLDAEPLNLYILLLDIDRFKYVNDTYGHLA
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
ADGEIGITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A7W2V114|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVL
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSIPVDVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>W2UHS5|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium MOLA455|TrEMBL
MNDIFHTKGVGEAGSELSRALIAARLQGGVMVVDRNLRVVMIDRKAADFCRVSSGQSQGK
RFYSLFPALLGSGFSGELHQIISVTGNSRFTRPADNSLLDQFTEAFSRDSSTLLEVSMSV
YDDGSNNYCLIRFSLQAETENGAKNDLENSPETKNVELADQQLDTFLVDKSAAYITTDQF
GFISQISPAAETLFGYSRELLLGSSVRTLFPGLDDMHGLDLVENITSLATQHNQGYVLAA
TCHGESRYLDVKLFRSAGNQEQLIILCHDCTQVSQQAEELINRGELYDLTSKHIADAVTL
VDAEGFVLEMNPIAEQLLGFTLDKSKPVQIHAAMPLSNEDTGIAETPVQDALNKALNVES
NQSLLLKVRGAAPVSVSVSAFPLRDAMGRIVKCLVIFRPLSEARRVSSRLQWQSMHDSLT
GLPNRTSLSKRIQKAIAIARQEGAIHALLYIDLYNFSVINDTSGHTAGDELLKEFAQLLI
RLAGPSDIAARIGNDEFALLIHRVNYDKAMILAERILAELKELRVPWEGEVLKIGASIGA
ILIDDTALSDIDLMISAGSSCATARDKGRNKIHFQSFNEEVARRRSLATSMPKIVSALDE
DRFTLFAQPIVPLNGSTATAKCYEVLVRMRESDGTILPPSEFIPGAEHFSLIDDLDKWVF
SHSLKFLQRLQAKGSPLPLLSVNLSGSTVGDENAIDYILSGFSDTGISPKHIQFEITETA
AVKHLQEAKRLISTLRSVGVSIALDDFGSGLSSFAYLKELPIDCLKIDSSFIHTMENSDV
DYSVVSTINHLGHIMGVTTVAEGVENENQLRLLKKIGVDYLQGFLFQHPQPLDQFGR
>A0A8G0WLB4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MMDNRSGKGLSFVRRIYLPRIIGLGIGMLAVMAGISGLDIPQWAWVLLLFNGLIWPHLAF
QLARRAGVPYHAEYRNLLFDSLMGGFWTATMQFNPLPSVTILAMMAMNNFAAGGQRLFLK
GLLIQGLGGGLSIALFGAGLQLQATPMQIYACLPMLTLYPMAVGWVCYNLAMKLAEHKRR
LSALSRTDSLTGLLNHGSWKDLLQLKFQICQQQHCQAVIALIDIDHFKAINDTYGHVVGD
CVLTQLSSELKRGLREDDLAGRYGGDEFCLILPNSDVEQARQTMERLRERIGSYRNPQLP
ALRISLSIGLASCREDLTDAEAWLNEADKALYVAKNSGRNQVNFSQPDLTTLKLAYPQ
>A0A239S9N1|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MVSVSQQDSNARADGTPQHRRTGGAASASAAAGIDPAVAGKGKRFVRRIYRLRTIGLGIG
FFCVAGVFYRLDPPTPLWLWALVIFHGFVWPHLACVLALSRPIPYRAERTNLMIDAAFGG
FWVAAMQFNLLPSVVVLAMMSMDNIGAGGVRLFLQGLLANVVGALIGIAVLGFAWAPASD
TFNVITSLPMVILYPVALGKVTYDLAQKLSQRSREMEYLSRHDGLTGLLNRRAWEQRLAD
IHEHCAHTGQPACLVLMDLDHFKRINDTLGHAAGDSALRRFAGLLRQRLREIDAVGRYGG
EEFGAVLVNTGEVAGRDLMHRLLADLRARVAQAEAQMRQDEALRVSLTECTVSIGLVPFS
SAFSTPHAWLQQADRALYRAKSQGRDGMVVLEAGAFGMSGAGASPDREEATGGTDARGAK
NV
>A0A518AKJ2|diguanylate cyclase|EC 2.7.7.65|Aeoliella mucimassa|TrEMBL
MRGGLAGRIAITRMKNGYQPRVTTFPPHDLRGHVLGGLTLESIHAIYAFIPVSLPTLASF
LMSSTLLFVLAGCLLGLVQMAIGIAIGVWLRSSSTDSRNADLRRTRSVALELHRLTQKIG
TSVSDHRDRFEKMESRLQESPGGRHNPTTDLVAGVVGEILAANRQLQTELHQAEQQIADQ
AREIESHMTSALTDPLTKLPNRRALDDQMANRLRDYRKLGTPFSLLMIDVDHFKAINDDF
GHQTGDEVLAGMGGVLRASLRRHDFVARYGGEEFAVILPHSSLDEAQCAANKAREGFTQL
SDLFAHLKRNITVSGGLATIQPGEELDHLIARADEALYLAKRSGRDRTYMHDGLICRELD
EESLTEGNGLDSSAASSAPTKDTLNSLPTSAAMATACSDLRSAVFGSADSAK
>A0A0P0RJQ7|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia caribensis MBA4|TrEMBL
MLKLDPDQLENDWRDMLAGFSPDTVATVRQLADLHRRELATYFYQQMLNDPIASRLVSHD
QVKSHLHSSMTSWVKDVFAVSEAGDLQLLIEQLVKIGEVHGRIDVPVHLVIRGARNLKEG
FFRLLQASGSMDKQSSMSAARLVSSVIDMAMEMMSFAYSSSHDRNSRAEEAYRLLSVVEN
VAAEQERQRAALLDWENAVMFEQAVNPRASDVPRLQTSEFGLWYRHKGAAAFEGTVETSV
ILDAMDRIDNELLPLVEGCREDMPQRKVQLLRDLHTQTNSIEFSLDTLFKQSNEVESGRD
VLTRLLNRKFLPVVLSKEVKYARRKNTNFAVLAIDIDHFKSINDTYGHESGDMVLQQLAG
LLINCCRGGDYTFRLGGEEFLVVLVDVTEDSGKKVAEKLLRLVAETPFRVASESPLRVSI
SVGVAFNNGHPDYQRTLNLADEALYTAKRTGRNRVTVAADAQPVPAS
>A0A6I6EDS6|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. J780|TrEMBL
MIADKSSRAFRPEHIVHICFAIVFVFSTLLTWREAQVLKSSYETDQRAWLAQLASGLEHQ
LQQSIDEMYFFRNMLHHALDEPLVTDKSREALAAFAVKRHHPLWKININSERSMPLNGIS
DEALQSFPLLSRADPKRLDDELTAVLEMSYILQFNNPVNDLHYRLWYISRAGFYLSSVQD
DKQETVKSYSTAIDRPYFLNAHPQSNPDRGMRWSEIYHSLYNEGEVVTVTLPVDHDNYWY
GELAMDFSTEAIQRYLRQTLPTWQAGHVMLFDRKHKPLAISDGKKMSEQGINSAELAEIF
NKRPDEKSGQIRSGTRFITWVRLQHFDGMMINVQTLDEGMRGETGRVTLVLVLMWGLFTL
VLLACHQAIFRMIRRLLSLQETLKWRANYDGLTRQLNRSAFFEQARKQSAFCERHQLPLS
LIQLDLDHFKSVNDTWGHHAGDVVLTHAASVIARTLRKEDVLGRVGGEEFCVVLPDTSLA
EAVEIAERIRCKLASKEVLINAMKTLKVTASLGVSSSDEQQDYKIENLQSIADERLYRAK
QAGRNCVSSGG
>A0A8F7LF11|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MMKSMLLRFLSHRVAWLAVVVSLGIGALFAHTMWSMRQEHWDYQLRTNTNLSSTLAKGLE
WSLDAVDLSLQKTAIALNEVRALEGQEDSESHRALLDSLWRDIHNSDLLVLDDQGRVIHR
ALGVQSVGKQFVSHDFFQAFRVHQLPGVFIGQPTKELRMGEYVLPIARAIRGKYGVLNGV
VVGMLRMQEINAWLSTMDLGAHSGVNVIREDGLVLTRFPYQETTAPHSLAGSGNLAQFVA
APQGSFVGTAVIDGVERLYTHNRVGHFPVVVNVAQSTNSIFQSWRRNAWQLAGFAALLMV
SCLGLAVLFVRELTRREATEADLFTEKERMRLTLQSIGDAVVCTDAQGHITYLNPVARQI
TGLEMREVESHPIEVLHALPYAVAGGAQASALRRALESGKTVDRSRTTLLHRGSGELLEM
DESASLVKSFDGHVLGAVAVLRDVTVAAAHEARMQRLAFHDVLTGLPNRTLLQDRAQQAM
AHSKRTGDMLAVLYLDLDGFKQINDSLGHQAGDAALVHAAKALQASVRESDTVCRLGGDE
FVILLCELASKTHLQNIAHKVQQACATPFVWQGASYVLHASGGVALYPDHALQWDALLHC
ADTAMYASKQAGRHQIRLYQAHAEAVLLARAEAAAQAVVGPKA
>A0A427URP3|diguanylate cyclase|EC 2.7.7.65|Atlantibacter subterranea|TrEMBL
MIKDINSMPRPTFKRTLRRISMISVVITMIIVWLLLSVSSMLTLKQYAQNNLRLLSVSIS
HTLEAAMVFRDGPAAYDTLAALGAQGQFASAQVVDNMGEIIADWSGTVENDRDVMGGLVS
KWVFPTPVVQQIYHNGSVLGEIRLTAMDNIITHFVWTSLGVLTACLILASCISLSITRYL
HKGMVNALNNITEVAHDVQTNRNFSRRVSAERIEEFHRFGQDFNTLLDEMETWQTQLQRK
NASLLISATHDPLTGLANRTAFRQAVETMMNDRSRKIDAALLFMDGDNFKQINDTWGHAA
GDRVLIEAAQRLRNFSGETHCAYRLGGDEFAILLTGVHSTDELLMCITDLRQALLPPILL
NNGETTVLSMSIGYALAKCTATPEALMEIADKNMYHDKSKRRLAFG
>A0A5Y6M8B5|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGTLLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A0Q0ING1|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MKYYLRLPALLKGCLGLLSLLVSITSLANTLEANEFSNPEFDALFTIVDHGDINDERYPQ
TIEQLTQMITKGDMVRTHKLLPKQCLAFNFFEPEQNEQAASFIINAYENYPEMPHAIRIE
LSLCEATLLRYRGEINNANELIKQALADAKQIEHLRLIADAYSMLGQIASYTGDFAIALE
NLLQSYEIYQRLNLPTLEHLGLLDLAITYRRLGETDTALKYYQEVERQFSSTGQTALVMI
VKNDMAYAYEDLQQYQKAADNYLSIYNYYQKVHTDPTFVARVAVDMSSALIHLGQYQQAL
NYLNQYENIVSPAVDTHYSFLQLHQAQAKHGLGQTQAALPHLEKAIAGFDKNNNKRGHEM
LLKLQVEIYESLEWWQQAYEAQLALYDIHVLLDKALKNQASTEMRVRFDSQKLEAENAEL
VAFHQLKDEQLVIRQDNERLQVLALMLGVASVLTLVLFSVFLNKKSKQLKYLALTDSLTQ
LPNRLSFYRRANSSFDKHIQDKTPLSIISIDIDHFKKVNDNHGHVCGDRVLKAVANIIRK
HIKEDDIAGRVGGEEFIILLPKARSQAAVSLAQEISASVNLYQFSNFSDNLEVTISGGVS
TSHGETTLSQLIKKADLALYRAKHQGRNQIVYFHDDD
>A0A174J6R6|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MVRQSEHLRTILDIQYDYLNALAEEIGKTDHLLAKKNMDLIKSITKHTDFGGTALIEPNG
DAHYDNGLIKNLSHRRYFKEVISGRRTLSDPLDSSISGSTRVVLGVPVYNSKHKVIGALG
GSYDVTALSRMLFEDLFNGQGCSMIIAQSGEIIAFEGDTSYWNLDYRDNFYKCCCKWIIK
DKVTVKKIKQDFKEGKENLVTADSKKEGTRRHYFAYMPMGANGWMLCYALPEQAAQQSYN
FIEDYEISFMIVFIVLVTLLILYIVYENHTRNKELLKYAQTDALTGLYNKETTEQLTDEL
LSEDENKSHAFLILDVDCFKQINDIYGHAVGDIVLQKFGKLLKGTFREGDILGRIGGDEF
GVIMKNIQTKDIAMKKAGELLAKTQAYRIDELKGNNISISIGISTAPQDGDCYMDLYKRA
DQALYQAKRSGKARVCNYFS
>A0A2K9K1U3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MPTFSISVCSAVMSCNRFLLLESVSFYFSKNNNNMNARRYRYNMLLSLLLLVGFIFTSWI
SIEHAKQSLYKGVSDDALPLTSHLIDLDIQKRLQAPIIVSQQMANNVFIKRWLTSSQQDP
ALIFTYLEDTRVLHHAKTSFLVDDKNLTYYHFDGNTQQLDIRAKQNDWYRESLHSDADYA
LNVDIDPRDNNEAIVYVNHKIRQNNDVIGVVGVGILLADLHNLIEQYEASYARKLYFIDH
KGRLLFFNDQTLSGTSIHDRFPTQATALLNQSEYQFRLETDDHAEFVHSRYLDSIGWYLI
VEQTIDKSSGISDILTTNLWVGSLVTLLILAVAQLTFNHYQKRLEKMAKYDKLTDTFNRQ
AFEPQLQHHLAKARTQSTPVVMLMMDIDHFKQVNDQHGHVVGDRVLQCFSNVCKRQIENN
GLLCRWGGEEFMVLLPKATLEQGIAIAEKIHVALEQAECEVKVTVSIGVAQYHIDESEDG
FIKRADAALYRAKQGRNQTKFAA
>A0A744N9G6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEIRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5T5NT21|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIVSWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1V5FG52|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MAYVHPTHARAAQRSLGVLGVGLAGVLALWWLPTRWAAGLAHYLPLHLALETASIVAAVL
VFAVAWLTPERSAAANTRILGCCFLGVAVLDFTHMLSYLGMPDFITPSSPEKAIDFWIAA
RLLAALGMLTAVLLPWRVRPGLSPGLLLLAVGAYVGLAHALFLPRPEWAPRTFIPGQGLT
GLKIGIEIGLVLLFAASAALLLRRMRAPCGFDAPALFGAAGLMALSELFFTMYAQVTDLY
NLAGHLYKIAAHALLFRALVVDGIRRPYAALERSRHELADNSARLADERQRLESILAGTR
AGTWEWNVQTGATIFNARWAEMLGYRLDELEPLSIDTWRRFAHPDDLADSDAAVRRHLRG
ETPYYEHETRMRHRAGHWIHVQDRGVLRTHTADGAPEWMFGTHIDITDRYRAEQERAGAL
KRLRQLSESVPGVLFECRVEDDGKVSFPYVGRQIEALIGCRAEEVEHDAAAFYARLHPDD
GARVRDEIRHARHGMHDWNASFRVVHPLYGERRIRGEARCQPRTDGVGEWFGYLQDETGT
HRDQERLRLGARVFDASQEGILVTDAAVRIVDMNPAMEALSGHAKASLLGRNPRELGSGR
HDAAFFAEMYASLARDGRWQGEIWNRHSSGEIYVVKASMSTVLDESGRIEHYVGVFTDIS
TLMAQRDHFSSLANFDALTGLPNRRLLDDRLQQAVGNARRGKPLVVCMLDLDGFKPVNDS
VGHAEGDRLLVELAQRMQHILRAGETLARLGGDEFVLLLVDGDFRPALERVLEVTRAPVA
LSGGRFARVTASIGASAYRHGVEDGAQLLREADQALYRAKRAGRNRWVMFAPEAAAGVET
PPA
>A0A505C9W4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A763XMT4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAERLQELADRNMYQAKHRRAERSLN
>A0A5C2LTL1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKILAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U2F646|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVTKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A632AZK1|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLRGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5U0N3S3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y7AHG4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Infantis str. CFSAN000522|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNILRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3W8M959|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSALEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A622P286|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARSIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Y2Q9R0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRIRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5C2LV43|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A625WNB3|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A750P1X4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQNQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDAAEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWGLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A378CS55|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MTQRLQGCETIEDVIKVAERFAPNIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFS
PDDCWAIRRGLSHPPVQGEPDITCYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDA
PSRAYLELMAEALGLALANQRLRSALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHT
PLSCLMIDIDHFKTINDRYGHEAGDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGI
DEAGAHQCASEIYTQVRNMTLRDGLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRA
KELGRSRIVSFGRLKTS
>A0A0T9KPJ5|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MQTPPKPPDESARIATLRAYNILDTSPEERFDRITRLAKRLFNVPIALISLVDVNRQWFK
SSVGLAASETSRDISFCGHAILEEGILMVPDALTDQRFCDNPLVIDAPGIRFYAGCPLVV
PNGSKLGTLCLIDLEPRSLDETDQQLLCDLAKMAEQEIAAVQLATIDELTQLTNRRGFEI
LAQHALTYCVHNNIPASVVFFDLNNFKAINDTFGHAEGDKALMTFADELQLFFSETDIVA
RLGGDEFVALLTASGCKDMVDILSRFKIALEQRNRRELRGYNICFSVGYANCDFDKFTTI
KALLAAADSSMYTHKLELRDKRKPHPKN
>A0A2S0XN26|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MIGQQKLESRGRMFSKLSAFSNRKWFQVTLLTVAGTLAYIAISWALQALVFGGADAVRPG
LLTAFILPVLFIAPLLAFLGLKLHENASLKQQYAQELAHDSLTSCLNGTLFSAAIDVFAT
GTGRRKGALLMVDIDHLKRINEHIGYSAGNQAISVIAGIIRSTVRSGDLVGRIGGDEFGV
YLPGASKENAEKVAERIRHAVSEVRFEPSGSNWPLTVSVGAVLFETEATADDLLVAADHQ
IRIAKEKGRNRIESTRLPDGRSSSRPSLH
>A0A6S7AIN5|diguanylate cyclase|EC 2.7.7.65|Achromobacter animicus|TrEMBL
MSSSSTGVPPAATARAAPANAASANAAGGHDCYLSASNAQAWEAVYQSVDADTRGKVAAV
VSDHATQLVDAFYSTLLADAEAGPRLSHEIVSTRLHRGMTHWLKGLLCVRDQGDIDVLLA
TQKKVGEVHARVHIPIHLVMAGARILKNEIAQRLRASGLDGMATSVATQYVCNLFDLAIE
QMSRAFMRDINRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRTPEQAL
PRLAASEFGLWLQHKGAVLFESAPALRQITEAVARLDDTVLPRMMQGRGHEQESLPDQVR
ELQELVARIKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISLAQRQRSSFSVL
LLDIDHFKAINDAHGHAGGDQILRQFAEVVHQTCRSSDFVFRYGGEEFLVVLVDTGPGAA
LAAAEKLNAEIRRHRFMLAEAGALQVTASIGVATFDGHPDYAYLIDRADKALYKAKQAGR
DRSVEA
>A0A290HEF2|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MDFLCNLIWGLGAYLLERSNKKVFKNKEILAKLAVTDKLTGLYNRAKFDEVLSHELARTE
RFHHTFGLVIMDIDYFKSVNDTHGHHVGDTFLVEISTVIQSCIRSTDVLVRWGGEEFALI
CLESSLPGILTLVETIRLTIEEHVFAHVGKRTISIGVTLYKENDTDTLMVSRADLALYEA
KNSGRNCIKVAL
>A0A290HZS0|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MRLKTKVVVIIAGLLLGVSITGSVINYMKNVHDTQEQLQNTSLPLSVDNIYTEIQQRMIE
PLLVSSLMSHDTFLRDWLMSGEKDIDGIVRYLTEIQQKYDIFTTFLVSDKTKNYYHPRGL
IDVINKDNSADAWYFRFKDQPEPYEINLDHNANLSDTLIMFINYKVMNYKNEMIGVTGVG
VRLLNIEKMLNSFKTKYKYDVYFVDQKGEITLFSQALNKRGNIANIDGLKSIKEAIYKGE
QTQFEYKNKEGEYLLNTKYIGKLKLQLFVEINKKEYLKELKKTFYANLAISLLVTLLVTL
IIIYTINIYQKQLVKMASEDSLTGLANRRKFNEHFEKFYKLYKKGINSLTLVLIDIDNFK
EVNDSFGHLVGDEALVRVAEILRVELRSSDMIARWGGEEFALLFVDVSPEKSVEIAQKIC
QAIREDKALSSLLQRPLTVSIGVGHLSSLESQDGLVYKVDNALYEAKKAGKDQVIVA
>Q7W7K2|diguanylate cyclase|EC 2.7.7.65|Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKPGGRNRCVLANAGPAEPSQRPDAVSQSGQH
>V6F1D3|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MEPGGQRSGCTVLVVEDNPGDARLVELYLLEDITSPFRVLKAELLSAALGLLDTNIIDVV
LLDLSLPDSFGMDTLDRLRAAHPLVPVVVLTGTNDEALALQALRQGAQDYLVKGQGDGNL
VRRAIFYAIERSHAASALKRSEGRFRALFANAGLGVVLADAHGRMVEANPAFLSMVGYGD
AELRGEKFRAITYPDDIGLNDTLRAEVLDGSRDGFQLTKRYVAKDGRIIWAKLTCTVMRE
ADGQQPFTVTVVEDITERKRLEDNMRLAATVFENSGDGLFVTDAENRIIHVNPAFTRITG
YAADEVLGRNPSLLASGRHDHDFFIQLWAVLLRDGKWQGEIWDRRKDGEMFAGWQNIAVV
RDTDGKVQNFVAVISDITSRKQVEERLSYAANHDPLTRLPNRTLFQERLTRAIARASRNH
NLVALLFIDLDRFKQVNDTMGHLAGDMLLQQVAERLSSCIRQGDTVARLSGDEFTIILED
VQDPRDAAVVGHKVLRLLQEPVALTGGEAHISSSIGVSLYPTDAGDPQTLLKLADAAMYR
AKHLGRNSCQFHSEAVNAEAFERLALENALRGAVDQGQFLLHYQPIFDVKSGRAVAVEAL
LRWRHPEVGVVAPNQFLALAEETGMIVPIGRWVFDQACRQAKLWRDAGHVDLRLHINLSP
RQLRQPDLIEMVAAALEVSQLPPQALVLEVMETCVIDKAFDPSALFARFAALGVGLAIDE
FGSGYSSFAFLRRLPVTILKVAQSFVRNLSSSEDESEIVTAIVALARGLHMTVVAPGIEN
KAQLDFLTGFGCDKVQGFLLSKPLPGTEMTEFLDLKRSPAALGPWGNP
>A0A0N0XIB4|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MSLEQTSLLDAELDRVRLFLKSAPDEARRAALDIAEEASVLRARKTLTRAQLYHALALSW
EGEDAATGMLEKAIDLARRQRLIADLPMALDRAADLALMHGHFDMAMRHWVECLEYAMQT
QDTAMCVCGHLGVGKIYYALEDYEQAKTHHLRSAGYGLAFYDPTIYSAIYLCLATDYLRL
GQVPSAFVALKIAHDALPEVHGFETWHVELSVYYAEAHAASGHAAEAQRWLSQALALSHD
AGPLFRWSRALALLAHGTFLARNSDAEDAIVSLHEALEFANAVNASWQVLQAHRLLYQLY
KDSAQHELALNHHRSLHQCQITLQQRAREQRLQRVTQRRLHKLEQRMELEQARHENHHLM
ARVQTHEQTIQNLASAAQTDPLTGAWNRRALEDRLQALHAEARGLQQAMAVLMIDLDHFK
DINDRFTHLVGDKVLQQVVKLIGQTCRNNEFIARYGGEEFTLLLPGATLEAASHVAERVR
HAVADYDWSTLDAALQVTVSIGAAALRTDEPHQALLARADMALYAAKRAGRNRINS
>A0A0N0GMD2|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MNTSRLYFLQRMLAIVWPFMLIVLVLVMLQWACLDLLAAGRAYVGGESMWSKGQKDAAYY
LARYIDYGEVRDYRAYEAAVAIPLADQRARLELDMPRPDRAVITTNLLQGGNDRADIPGM
IRLYLHFKWAPDIAAAIDVWQRADMQINRLQQLAAHARQLRERENVSTADLDTLRQQIRT
LNASLTPLEAEFSQRLSHASRKMEVGLASGFTLAAILLIALALRRTFKLVRQRELSDAAL
RHSEQRFQLAVNGSNDGIWDWDMTTDHVWYSPRFRQLLGVNEHELAETPDAWFDRVHPDD
QPLIAVARSKRFRNGQAHDVEYRVLTGHNGYHWFRVRGRAAFDLEGRPVRMAGSITDITD
RKAAELALHLEKEKAEITLASIADAVITTDILGRIQYLNPAAERLLSIARDSAAARSLDD
ICRLVDQTEMAISLLADDANLPDALDPNLRDFRLLRHDGVEVSVDRALAPLRGRHGDVTG
MVLVLHDATRERQYAANLSWQASHDALTGLVNRREFERRLAQLYNRTLQRAAQHALMFLD
LDQFKIVNDTCGHAAGDELLRQLAGVLQQHLRQTDTLARIGGDEFGVLLENCAPEQALRI
AETLRQSVRDFHFAFGSQSFAIGASIGMVHIGDNHMALQELLRAADAACYMAKEKGRNRV
QQYSPQDHEVTLRHGEMEWVQRLKRALSEDRFRLYAQEIVGLSSASFGQRHVEVLLRLLD
EHDQIVPPMAFIPAAERYNLMPDIDRWVLLNTLKTLAAREQAGLPPLALCAINLSGASVG
DEHFLQYALEQIRQSGIDPARLCFEITETTAVASLTRATWFMQQLSALGCCFALDDFGAG
MSSFGYLKHLPVQYLKIDGGFVKDMLNDPIDRAMVSAINEIGHLMGKQTVAEFVENQAIA
DALRQLGVDYAQGYGLARPEPFRLMHRDIPDARYA
>A0A0M7N1J3|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MLRSRFSIKSLERYFLILAAGVLLPMSVLTGILLLQSRAAYLATGDALRAFAIVRTTITA
METVSAERGPMNAALGADYPVAESLLDELRAARERSDTRIADLLALYRAPLNPNSAREFT
NIQRIRYALIKARDNADALIATPRADISGQRVLAAVNGMVALVPELQAAMAESAGVVMQN
EADAPNLLTLALLASELREQAGLLGSTFTPALAKHRQLTESDEYRMERVLGRIDQLHDLL
EMRLAARPDLRASLAYGDLRHFYFGEGMRYLAEVRDMAALQPGGATISARELAATYVPLM
HAISQFRDLMLDQMEASMREHRRHAIRLLVITLVAAAALAVALMLSLRQFRLRVIRPFVQ
ATRIIGAIANGTPAAAIPVGKYRGEVDGMFEALSVLKDNAAARKRAELERDRLIVDLAVM
AETDFLTGLLNRRAFESRLDQALSQWRGAGAALAFILFDIDDFKGINDTYGHASGDEALK
TVAELCRQTLRQADVVARVGGEEFAVLCHVGTADQAVEMAERMRQRIAQARVTAENGTVF
GLTASFGVALARGPEAGTADTLFRRADELLYRAKMDGKNRVVPGDTG
>A0A6N2R717|diguanylate cyclase|EC 2.7.7.65|Campylobacter ureolyticus|TrEMBL
MKKSDEIIKDIQNRNNNYLIMINDFGVSLAKNNLSFFEIQSFFKNLANYAAHQFEDLKQI
FDEFEIDERQVQSHIKNQKIFLNEVNYMCSYVSDDVYKIKPLLNFLIFWSESEVNNQNFL
LFKQVELIKKGMTPSDAYELMSLHDNTTFARTINNFINTLIQKNEELAQNNIALQIKLNK
TTKKLNALNKELDAFPVTDPITNLSNRTQALKALNILFKEENKNVGALLFSLTSYNDMIN
QLGYEVTNNIFLAIIRIIKNSMRSDDLIYSMKKDELLLICQNLNETSAINIANMLIERIT
KNSVLNTLLGSFNKLSINIGIALLQSVLDSDDLLVLLDKKLKNAQSMGKNRIEI
>W6MA66|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MNQADAQDNQDNQDNQRAILVNHLKLVDDLWQKLFYVKWSTRSFAMLERLAQDMLQCAQS
DGDEQLLKLIIQLEHHVKSCLAAAGLPQESDRQRLTALIEALHEVLATGKEGSRYDQPLT
LARFTPFPQIVLITPDETTTTLAKLDEPRYQVLRINDLTEAERYLRERPPGAVILDVDFP
EGPERVLELIANLRAQAYLQVPLLVCSERSDMAARLEAVRVGAAAYFSKPVDHDELWGVL
GELLLPQMAANYYRVLIVNDRPSEAWEIAGTLEEQGVTPLVVIQPLQVLQDIHRFRPDLL
IIDLDIKEVAGAELAQVIAQHRECDFLPIILLCFQADMAHYLANLDLPGATLLVKPMPPS
HLCWEVKQRVRRSRSVRVRLSALSNSDGVSGFHNRRRFLMLLEQSFDTLGLRARSLAVLL
VVLDNLHSIRDAAGVATADEIIGQAASRLHQVLAQDQHAARFGDAVFAVMVPNLVGEPLM
HLARRIRDTLENGYYKVGEQALLVRIRVGMAVATDRTQDHLMLVQRADSACTMAREAKSE
RIYAHQNILAVKRDQEISSRTQLLEQVQDIFDHERLWLVFQPIVSIRGDAVERYEVLLRL
RDRQNLEIVPGSVFGVVHNHQLGLKLDRWVIEHAIEVLRQRRSPITLFIKILPITLQDRT
LSTWLRGRLEQAEVEAERIVFEVAEATAERSLRDMFGFLGGIKLLGCGFCLDRFGRGSDS
LGLLKNLGADYVKLDMYLVNGLARDRAKQAQLQDLVQSLEALGAATIVGGVEDVKTMPIL
WSLGVNLIQGFFLQQPYREMSYDFANAAF
>A0A2H6F2L6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin06|TrEMBL
MIDKTKEQLTEELNQLRLRVAELEKFDLIQRQIEKRIQESEKKFRTLFENATDAIYIIDP
KTQRILDCNPKASEITGCTIQELKSLTVADVHPIEEQDIVSKIFRKIAGKGSLSGISGIN
QIRKDGTTVPVEVNASTIDLEGRRCTLALIRDISARKHAEEELKKREEAALARSKAEFEA
MFNSIPDAAIYTDTNRCIVMTNPAVKKIFGYSQQDLQGKTPGILYATRSGYEERVRKRFN
AGADSHLEPYELMYCRENGSIFIGETLDARVVDSGGKTIGFIGIIRDVSKRKEIEQQLQA
AAITDDLTGLFNRRGFLTLSEQQRKIADRTGRLMSLLYLDLDGMKAINDEHGHKEGDQAL
VDTANILKRTFRESDIIGRIGGDEFAVFLTYISEPDIQHVIINHIQENLRIHNQKAGRNY
ELFLSIGIAYYNPEQPCSINELLTRSDQLMYKNKKNKFEEKTLKSLREKRIEHRAFERFQ
PTGNYRAKLNGSDKFRIKNISSGGLCLKTPKRFSVDTHYKTRMVAPDNKEIKSTAIVVWS
AQLKTGIPENYNSPYYETGLKFVDLSDSRKGSLQILIKNIIK
>A0A8J6M2F6|diguanylate cyclase|EC 2.7.7.65|Neptunicella marina|TrEMBL
MQKLRHHDLESLVQRLDLAIENHRLWVRQLMRILVCQSDHAELDKSDDAHTCCDFGRWYY
GQHPEGLLDNPTFKNIEFLHHEMHRIASGMLYKQDTGQGISEAEFETFYSELDVFVREVE
RLKAQMQKLLYLRDPLTGAYNRATLKEELYLLKDMLSKQVETACILMLDLDNFKGVNDRY
GHAAGDEVLKAVAEYIQDNLRTLDKFFRYGGEEFLVTLVNSNLPSALATAERMREGLCNL
VVEFGNSQIKISASIGVALIDAESDIKESLEQADKALYTAKRNGRNRVELWSQ
>A0A1T1H1X7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5600|TrEMBL
MNQECITGLSQTWKDICDQYTENEHLAALQFIQKHVEHLVTVFYEQMSREPASAEFFKDD
IIQKRLIDTLRKWLLETFNVALNNDFEISVKRQQKVGMVHARVGIPSWLIMRGVREIERK
IFEILELNHTQNILHMCSYIVQIIGFSTEIMCRSYEINTEKKQETKHNYRLFSAMQDVAV
HKDKQRGSLLNWENELMFKIFSGNVSFYHSLLSKSEFGLWFIHKAAYAFSGSDQVQLIID
RIYQVDELTQQTTQITDKDQLQHLIQQIRDLNREIQHLVDQLFQVAEYIESGNDSLTQLL
NRRYLSTIISREITFARQNKTPLSLLAFDADYFKMINDKFGHAAGDLALKFIAEALQRYS
QGSDYAFRIGGEEFLLLLVDTNVNRAMKVAENIRQYIENGVIRTVQGQQFSLTVSVGCVQ
YNGHPDYQRLLDAADIALYAAKNTGRNRIYVAKTDQQTRSSSS
>A0A5C5V4C0|diguanylate cyclase|EC 2.7.7.65|Blastopirellula retiformator|TrEMBL
MSVLTIDILLSIGCTAIGMACGWFLFGNHPSSPIRQLANAVTALLDYLRGQPQATTAKQV
VVAAEESQKTAPDHEPKTGGDALANITQDELSKLLEQVHALTESVRSDVGEHTDRMARIN
EGLASRTTDASSVTDAISNLIDANKSLGDRLNQAEMRLLEQSQIIQSQTVEARTDPLTGL
PNRRVFDHEMSRRMQDFQQSRRPTSLIMLDIDHFKKFNDTYGHMAGDEVLKNAARTLERV
AATIGGAAIRFGGEEFAIILPGSNIFDSQIAAARVVRAVASMEIVFEEKLLQVTTSVGVA
EFSRSDDEASLLKRADSALYAAKNAGRNRAYWNDGEKSRPVLSDSQKPEAAPVAESPPAE
PKRATVSDANQFRADVNRRLHQFKRDSLPISLVLLEVDRYDEFLQNNGQGVIKAFNDTLE
RMLIAAMRDMDHVGRVSDGRYGILLPSASINRAAAVSGRLRKAVERFKIRKDDEVRQFTI
SCGVTEALAGDGLDHIFLRAEAALGKAIEVHGNRVALCGSEMEIDSPILIRTSSAADRSE
PGSTATAR
>A0A554XID4|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MLSPRSIDPADAHHLPWWDTLREDYTLAVITLGGVVAALWLAPFAVWRALQGNWLAMAND
AVLTVLLGGSAIYAWRTRQTRVPGWIMAVCIVGGIWAIGVAAQFAALFWAYPGVLMMFFL
VPPWAAATLGAAAVVGAAALSWQELGGTEGLPFFVITNVLTGVYGFLVSQQAQRRIGRWQ
TLSLLDPLTGVGNRRLLEVEFAQGFAGTRSAGTLAVIDLDYFKAINDQHGHDAGDAVLRD
VAAVMQATVRKTDRVYRFGGEEFVLWLSPADAEVATAVLQRLRQAVRAQVRVGQTPVTFS
AGVATHVPAESWQACLARADAALYRAKGSGRDRVCWADSGEPPSRQ
>A0A6V8LTN3|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MLSCKARNKLLTKIVGLLVLVFLPAMGSIVYLNMALHDRGLQDARDKLDRTVRGFEIYQN
MLVTEIREILEVVSVLPEVRQADTGRIEETFRRLHRREGYLSNIFLTDPEGRVIASGVPD
PAGVNVEERRYFRAARDSGGFSAGEYALGRITGVPVLHFAFPVQDDAGTFAGVAAVALNL
NQYREVFRDVALPDGAAVGVYDANGVLLLRSPEASEVYQVGSSMRGDFYALLNRGDRRGC
FERTGSDGVEKVYFYARFTLPEEREPYLFVLLELPRDTFAGPVDRAALLIYAVTGFSILL
GLAGGYVLYKRVLVDRLHSLGGMMESLAAGDACLLPENFGDDEIGRLGSRFMDMAREVAA
KDDLLLASANTDALTGLFNRRKFNADLEHQVKLARRHERPLSLVLFDIDHFKAVNDRLGH
VAGDEVLHAVALAARAALRSTDLVYRVGGEEFAVLAPETPGEAGLAVAEKIRLAVEACQV
EHGAERVQVTVSAGTACLGDSAADAQELYRQADDALYAAKRAGRNRSVAAHTDGFCGDEP
PGREKAA
>A0A6V8LR18|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MRNAPTPEETLAKTTLLLVEDDDQTASDLQDLLRPLTREFLHASDGSQGLKIFRERRPDM
VLTALTLPPSLDGISLATILKTHAPDTPVLALVSQDEEPVLFQAVEAGIDGCLRKPLDRG
AALPVLYRHARHALHRRQEEARAALFSYLLDINPHCIISTREGRMDYANRTCLQHLGHET
LESLLEGRPGSRTSIHMAGENIPLHDFTWLDILRSKPGRQHTVCFSTDGEPCSGDNMFWV
THKGFPELDREVVTFTDITPLEQERVQLIYRATTDSLTGVANRYKLSEAINTEHVRFRRY
GAPLSLIMFDIDHFKAVNDTHGHMAGDLVLQELAGLVLRNIRDTDALGRWGGEEFMILSP
YTVQDDALELAGRLCEIVSRHPFAGAPGVTCSFGVAQARQGESLQTLLQRVDQAVYLAKR
NGRNRVEAA
>A0A7I6H160|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O9:H4 (strain HS)|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A379DTA7|diguanylate cyclase|EC 2.7.7.65|Pragia fontium|TrEMBL
MKFSISTIDYPPIDLRHIPLLIAACYVGPLAALITAIIISISCIIISFTETGTIVAINYC
IIGLVLTVCSYYIRRSIRYRAILFSIITLSFIVIGYAYSTGPNLVKFGEFTLLITLFTAV
SMYLAMMLLKDLKRKKLEILTYQGQAQHDFLTSLLNKRMFDRAIRHINQYKENTVLMLID
IDYFKKVNDIYGHDAGDLVLKEIASILNAHTAYGQKVFRIGGEEFSVILIDCPAPLAKKI
GEDICREVANHPFILSNGTRIRITISIGISSSGQDGDKNSLSLFRLADRALYQAKSDGRN
RVFYASDETVHHQTV
>A0A653J7J6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MTGFQFDKHLTNERLQLLVGSISEYAIYMLDPEGRVVTWNAGAQRFKGYFADEIIGQHFS
CFFRREDRDAGLPGRALRIAARDGRFEAEGWRVRRDGSEFWAHAILDPIRDDDGELLGYA
KITRDITEVRKREQALFDSEVQFRMLVQSVRDYAIYMLDIDGHVTSWNLGAETIKGYKWS
EIVGQHFSRFYTHDDQASGAPTLALQTAFDTGKFEAEARRVRKDGSPFWAHVIIEPIYND
AGEHVGFAKVTRDITEKKRLEDELTALARQDGLTGLGNRRLFDETLAREWRRTQREQMQM
SLLMIDVDHFKQFNDEYGHLSGDDCLRAIAKCVLAKIKRPGDAAFRYGGEELAVILANTD
STGAQHVAERIRASVVGLSVPHGSSFTSDVVTVSIGVGSAKAGPQGAVGEPSELIRAADL
ALYKAKHAGRNRVMVSDVIAPPAASDPA
>A0A380PQA5|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MSELDSLSTLYRDACVIYATLSISYFALSKNSAFSYDGDIWKRIVFGLVAGFVSLYLNQD
QWIISGSFFYSFELIPIILVTFYGGWLSGLTALAMNFAFTGWVTLDNILITIAFIPLLFS
KVWESKNSRIFYMTIILIAIYRMIAAYLLVPQSLTWAQVMVYQLISVLCLSICYHALNFK
ERHIYAYFSMKSRVNIDKLTQLNNRASVDYRLKAIHNRRQACGLMILDLDHFKSVNDTYG
HNGGDVLLTAVGKLLMTTVRDEDFVGRYGGEEFIIITHRHEPQAIKVVAERIRQRVEDLT
VEVPDGRKIKVTISIGASLYLPGMSMLKALKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRIAKEKRRRPS
>E1VB72|diguanylate cyclase|EC 2.7.7.65|Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)|TrEMBL
MVGRVSRLRRWLGRIGVRARGRVPRDRLRSTSPNDVERVRRQYQESEQRFRALLESLPKV
AVQGYDRDRRVIYWNEASTTLYGYTADEASGRLLEDLIIPDEMREGMIEAHRAWVEEGKE
IPAEEIELEHHSGERVPVFSHHVMLGEHTDSPLMFCVDVDLSDQKRAHRDLAFVTHFDTL
THLPNRNAFETELEGALESCLRRHAGLALIYLDVDRFSEINDALGYEQGDRLLVELARRL
GQEQRLTDLISRVSTDEFVLAFPGVNQREDVHRLIGKVQQALRRPFAVANGERRISAALG
VSLFPENGLSARELIRNADVAKNRAKLDGPGGLQFFQQHHHDELIREQRMVEQLERAIEH
RELSLHYQPQVSVASGRIENLEALLRWQPRDSSAFVSPGEFIPLAERSGLIHRLGDWVME
EACRQQAAWRRAGFTESRVDINLSGRQMLRSDTLARFEACLARHGLTPRDVGIELTENVL
IEAEPQVLEDLRRLYHRGVRIAIDDFGTGYSSLSYLKHFPVTALKVDRTFMRDAARQPED
RAIMEGAIFIGHRLGLEVVAEGVESAEQLDLIREMHCDLAQGYFFYHPMPAPDIQVLLSD
TAGWSASPS
>A0A4P7NXB5|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MLIDIKDVPEKAQRIFVQLIDIFEEQDINPTPLNYYIWYQYYKGDHPKFRQEMDNALQDP
FGYNDRLGRRLYDEYFSDEHSGNDFDRAFKRLINLVIKKMNVWSDKLEKHTQDLNQYTTS
LASKDIDAETLKELTHSVLNTASSMKQSSEEFQQEMLNSNEEILRLRKELIEARAETLTD
ELTEVGNRKAFNHAIQDLADSTQDNPQSLVLILTDIDHFKRFNDTFGHLVGDSVLRYFAN
LMKKTRDDTETVCRYGGEEFAILLSHSSLEKAKERAESIRHSLEIAKLKRKDSEKTLGKI
TASFGLAVYKGEEHETLDEWIKRADDALYEAKNQGRNRIITDEELETAKPLK
>A0A1U9Z3W3|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MYVLYWVFALLAQGIGLALLTVAGRDDLRLIGMIAFTGLIGARALSTAGLLSLCGEDRPA
AFTSVIVALWFAAVVVSRLAGFDSVANVASFYIAAFTVAIYGFYFMAKNLHALKGPFRQS
LMAIFVVEALTCLALLSAYNLQQEPPSLGSATTSVALITGFVLFSLKGFLAVWLTVERLE
SDLRDLAFSDPLTGVLNRRGVVDEIEKMSQRSAKSDQFAFFSLDLDDFKSINDVHGHNAG
DRALVNFTHVVRQCLRERDIFGRTGGEEFAIFTRVTDRNTAGQIAERIRSTLEATTFHED
GHELRMTVSIGVTLMRGRIGNIESMLSEADRALYQAKGDGRNRIVFYDGPTPQPAQSADR
EVALAV
>A0A5B7UMR8|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. YIM 121038|TrEMBL
MSELPDAQKSRALFIGVDRFSSLEPLPAVQRNLSTLVDLFSGDVWGMDPSCCTQLLNPAS
TREVDQAIFSAAEAATDTLLLYYAGHGLLDRQGRLYLGMPDSDTSAVHSTAFPYDWMRMR
LTDSGAARCVVILDCCFSARAMGVQSPASSIAALAEVEGTYVLAAAHESAIALAPPGEAF
TAFTGALVGVLTDGIADAPEFLDLDTVFLGVQSILRRQARPDPQCLGRNQVGRAAFVRNP
AYVPEQAHDFRSDLQAAMQDLHVARSLADTLQAVSDGLVSGLGYEMVCVNLVRPDGDLVV
ASFSGNIEVEGRITGQVGSRAAWDRHFSMGEAWGDLLRFIPYTESRLGDDDDIPGWYTDG
PLPRFEDEWHPLDRLFAAMYVPDGTRRQLLGVITVGGPPAGRRPNLEQRDALRSYAFQAA
IAISNARLRANMQRALVRLEREQKALRASEESFRQAFEYAPNGAAIAEMGGDQHGRILRT
NDALCRLLGRPARALRRYAFSDLVHPEDIELLLRTSAENGRVELRLGRRDGTYVWVSMRN
TVVADSPEGPRFLLTHVEDIQERKRRELELAHRASHDQLTGLSNSAELHVRLSAYLCQPY
GDLQEHHRHATAPQNDPHDTGLAVVFCALRDFKRINVRFGRQSGDLVLIEVGRRLAVFSR
EGDTIARLDGDEFVLLVDGITKFAAQDLVLRMQNNIRLPIGISGDQVVRIGWSFSITWAQ
CGMKAADVIRAAREAATD
>A0A4U8QA70|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MFQKVKTNFLGKTVDLYPEEIRIRNYKSLRDFSVVGVIISVAVLLFCLLLRDIVTFNTQF
LIMAVYYVAMLFLAEFLHKKKIKHIIFAFYAVITPVMIMAIMLGTFLDPTQPSITIMIFI
CVLPLFILDKPWRVCLYITIIAVIYCICNYLAKDFRLFLEDFVDLVAFYFLAAGVNFFIL
DDRLENVENYVKFREKSEKDVLTGIYNRGIGEEKIKHLAERKEYGAFCILDIDDFKSIND
TYGHASGDEVLKEIAKVIRAQFSKEDVFFRMGGDEFVVYSLKCADESICRQSLDCLYEKI
RGLQIACINYIPVNVSIGCCIYNQGTTDYHRLYQYGDKALYQSKHMGKGHYTIRVLSPGR
>A0A752VSX2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Carrau|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2J9H1Z5|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MKLKNLIYIFTTALVFFFGIFIYSSLHKAHVDFAQNQQNLYKVKRLRDLTEVFQSALLVH
RLKRISFMSDAITQSEILDAEKQVRLHADALVLPPSDKSATELEKQTHEMFNRAKFFVYR
LTANDNQELSAVGHLMQTQLDLKSSYYITELNKLYFLYVYNTTLSDTHSYKFIESVRLNN
RLTLTATELIDQLVDIKTDEVKRNQSYLRSIELIGVLDSLRSRVDFIIATAPDEAQPSAN
IDELLNKLSKESMQHLTADLTSVMQSRSSNAFDGFYRYIIGIDKASAIFVNNSYDLELHE
LEKKISVSRVQLYGMISLCWLLALFIVMPILVFSSKISLWLTLTNKNIMKLSRGDLDISP
DNSIMTGELSAISDAINQLRQNQIEKRLLETEKQELINELLEASSTDPLTNIYNRRKFFN
QCSQITEDDYPLAFCLIDIDNFKRLNDRYGHDVGDLALIAFSQMLEQSLPKSTVYCRYGG
EEFAILIKYENMQQSMRIIDVVRHRTEMLSIAIPNKPSVGFTISCGLARLDDYQNINHSI
KQADEALYYSKKRGKNQVSFYSPNGFISFDANDKNG
>A0A377P4H1|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MLLTKSYKKGVFITMSLTTMVLAFFLWNDYQGLKNYLGYTVDKGRSAIFAEEYINQKIAL
NLIKSFSISEYKNKKADSSVLSICNRMESINDIYGLNLTGHKYPKLAGTLQTKNSSCEDW
ARDIKYLAKFNSQEEAISQEYSFSNYHWKVQDSIRYYIDFENQYIYINKLVDSSRYAFNN
WLRYNGKFIDVDSNARSIKIDDEALRSLHDGQSVTSHIYDDGYTGDKIISMITPLFFGGN
LKGIIVTDVSINELAKAFYTFDRPFLWKYLTLSVIDRNSSEEINFNQPDKQLFGILNYDK
DITRYYTVHLKLDVQYFILNNLFLFILYIFITYSICKYLKYQISKNEILSLENITDSMTG
LYNRKILTQTLDARLKSLTEKNTPVTIIALDCDKLKVINDTLGHHMGDKAITLLGDAIQT
SIRKSDYGIRLGGDEFCIILIDCDVERAFITIDLIKQKLKVIDTDAIVNFSYGCYQMKSG
DTLSGAQIIADELLYKHKKTKG
>A0A379WDR8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADS
AITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGR
NRTEVAA
>A0A509DXH1|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MHQPHVQLDIEFVDAKRFPEQENIDHFFLSLGEKLRGMPPYDLLIVGDDIAVEQVLQRKD
GMFAGMPMVFFGINNLALLRALEAQQITGVVEAVSLVETMRFAHHLFPAQPLVFISDATV
TGKSDLDKFLPEAEKLSIPYEVVSLAEFSFEELPAKLQHYDSNTPILLIAAYFDKNAKKK
DFYESLSIVLGSANGPVFHLWEHGFGYGLFGGKIISHYQQGKVAARKAMEILHNDSSRSI
PIEYVSPNSWVFDYEVMQRFSIAASDLPAGSTLINRPSNQQPFKTIIYAIIGLLILASIV
QLYILKRRRKEQLKIKRLNEKLERTVAERTRDLEKTKEQVENSLRARDLILDNSIVAIVL
VVQNQISWCNSYCEYLFGYSEQELRDIPIDELMQEGIEFATVSAEVEEQIKNNGVYVDEV
HFKRKTGEYFWGLVNAKSVSHDTFREGILFIVSDISKIKTIQIELEMLNEKLIHISQTDE
LTQVANRRSINEILAREQNRLVRYQQSYCVILLDVDHFKAINDNFGHSEGDEVLKKIARL
LIEELRSVDEVGRWGGEEFMIVCPFTLADQALHIANMLREIIKLNIHVDGKAVTASFGVY
QPSSNDSVTNVLEEVDKALYKAKETRDAVAISPTLILD
>A0A3U2RQM8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGVGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PTAALFMMMSMNLMGAGGRWLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1S7QTI1|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tomkonis CFBP 6623|TrEMBL
MTMRFTQLRLAGPAAVLIAILLAGLAAIPYYGVARLDAELRQRQETLVGRNISIWISDVE
FALTAWTIWDESIAKIDNLFDPEWTDRNIGRSLIGTSRTRFVSILNGEGDLIYSKTDDEV
LQRPFFARGADVIAQDAHSLVDAVRAKERGERPEGIPQPIAFSKIEVIGDDAVLLTASLF
QSDFRTATPRGERAPVLISAIPIAGSLQEFLGNRFLLDDASVGPAGSVPAKRARVEIAMG
PNGQAQALSWQPLTPARDLLRQSLPLAVTVLVVLIAGGIFAVRMSRRAVHSLVEAEKQMR
HAATHDFLTGLANRSLVASEFARLSQQGHLTVACLDLDGFKAINDSHGHAAGDALLKAVA
ARLRAACQERDVVFRLGGDEFAVLMPAISLAEAEMRCRQLCVLLSEPYIVDDGVMIIGAS
FGLSSVTGAETSCDEAFRCADEALYRAKGEGRGKVMTSLCEIEPVLRFG
>A0A4P7YH32|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. TSH100|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYREGRGGERSSAPASFEAWCQAARRDDL
LQQPAVQKLANLHEQMHRQARLILLKASGGELPTESEYEGVIGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETGLDEGYAVIERLRVDLMRSPVVLPDG
RVIPVTASFGLVEAVADLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEAKPAVAKAG
R
>A0A6C8G6R0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Infantis str. SARB27|TrEMBL
MLFSTLLTWREVMILKDAYVASQRNHLGSVANVLDRQLQFNMDRLIFLRNGMHEALVAPL
AFSALQSAVTQFEQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTA
TLELGYLARLARSSAMLTLETMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQ
RRNPQRGVRWFTSAQPYVADEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEK
DIEGEYQLYDNHLRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWER
LDHFDGVLLRVHTLREGIQGNFGSISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNS
LQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGD
RVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVLPGATKTQALQIAERIRQRINDKEILVTK
STTLRISASMGISSAEEYGDYDFEQLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A811VST5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTLCISLFFVLGGPIVAHILSSHYESYDLHIAELTNENGQVVWKASYVTIMIFMWLTLLS
VNLYFNGLRYDIWNGVTVIAFCAVLYNVSLLFMSRYSVSIWYISRTIEVVSKLTVMVIFM
CHIFSALRVTKDIAHRDPLTNIFNRNYFFNELTVQSASAKKTPYCVMLMDIDHFKKVNDT
WGHPIGDQVIKTVVNIIGKSIRPDDLFARVGGEEFGVLLTDIDTERAKALAERIRENVER
LTGDNPEYAIPQKVTISIGAVVTQGNALNPNEIYRLADNALYEAKETGRNKVVVRDVVNF
CESP
>A0A6D0IFP0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
IFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEK
ERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLI
QDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTK
LLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYD
NVRSSDYVFRYWGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGA
AMFNGHPDYERLIQIADEALYIAKRRGRNRVE
>A0A827BBQ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLISLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMAWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVLLLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRIIVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGWV
TVYEPQQTAKHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPDTRNLWLISLKLWSSE
GEIIDELAFRRSFSDPALNHALDRRILHEFFQQTAKAVASKGLSIALPLSVAGLSSAPLV
DKLLAQLESSPLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSGMGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376M640|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGKFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWCSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVRPLWCTVGIRSTADLLSTDTNL
>A0A2J0XUV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0K5YGK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLSRHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A826V2K7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTL
VSHPPSGWWWLVLVGWAFVWPHLAWQLASRAIDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWELMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A827BE09|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYTQKNLALTAATMT
YSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAVRETSALLFLDGDNFKYINDTWGHAT
GDQVLIEIATRLMEFSGKRHQAYRIGGDEFAMILYGVQSEYEVQRICTALTQTFHRPFDL
HNGHQTSMTLSIGYALTREHASAEKLQELADRNMYQAKHQRAEKLVK
>A0A2T3UXP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKAL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYCITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A6L7CNU4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
VRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLA
NRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEVGG
LRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMT
IEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A7H9LTK3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRDKVAEIAVAHAQYLSFEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTEDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQVDFGLWFNHKGRHYFSGIAEVGHISH
LIQDFDGVFNQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3L2AEW1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H1M8V2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTVRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTCDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8E6K4R6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000542|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGELRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A376JL36|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFKYKKKAAGICFLYFLCVSVMTCYLYTIYVKDRVNSVKVSIIDSGLAIANVSEYRRLVF
NNVFYGLDISPEELLKRIRNSFADFQKPEYIYDLGPYIISDGKCAKVTTEGDNFCDGIVS
SIRISNIFERGIISLNNKYYIYYAHPISKRTSLISVVDPERYLALIRNQSGERENIYVSF
YDINDNEKKIAGDDFLINDAVFEKSAITLAYSYIPEVMFIVAYKKDKYIYMCLLFVFTSA
ISAGLIYFHYIKLMQKIINKGKSEKESILSNNHYNLHGKNLFFNVEEIDAIREIYDSGTY
DALTRASGRRVFDNNIRMLSKDFGYLCLFDVDKFKTINDKFGHLFGDEVLIRLVNLIKDE
LPLSKGEVYRFGGDEFAIIYHDKDINQLSRILHRIVHFSIGGLNCSCSIGVANTDECMNN
IERLKLLADERLYKSKQNGRAQVTWC
>A0A377DS94|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNPLIISYGNAEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVY
RYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLD
VVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6D0EEQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLHDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWELLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A193LUA3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADHR
LYLAKQAGRNRVFASDNA
>A0A376JLJ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHQTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A377CYW0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2X1KBQ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHSHP
>A0A6G4PGU3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLAWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7D3P4Z6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQAPGIPENEEQRLKSLYITGLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A5C9AK67|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRF
>A0A6N8NBR8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDGVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1X7BL30|diguanylate cyclase|EC 2.7.7.65|Roseovarius aestuarii|TrEMBL
MTQNASIQQLGHLLNIICPMHAVLDHTGHIVHAGASTNKLLRTEDATGARFLEIFELKRP
RRVSTMQELCAIDGVKLHLQLRAAPRTELKGVLVPLGDTPAFGPAGGAIVNLSFGISVLE
AVKDFSLTSADFAVTDLAVEMLYLVEAKSAVMEASRKLNLRLQGAKIAAEEQAFTDTLTG
LGNRRAMDQVLSRLMETEQDFALMHLDLDYFKAVNDNMGHAAGDHVLQRVAELMVAETRG
DDTIIRAGGDEFVLVFARLINQERVSEIANRLISRLEEPILFNGRECRISASIGTTISGN
YKMPALEQMMDDADVALYAAKRRGRGQHVLFDPSLRGGDSVVTMHQAR
>A0A377D3U4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLL
NRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCA
RKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGN
ESIDELFKRVDDALYRAKNDGTQPRAGGISRGCVSRSTTALSVALPVFLLRLRRFT
>A0A5N8H9I7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPFA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGG
>A0A378B2F8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MPNQASRTLSGEMSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVY
CKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDP
HKDGRIVDANIAALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTH
ILADGSLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREF
HRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRW
GGEEFLLFLPHSPIAAR
>A0A6N0IEL6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRLFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2S8JXK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377A108|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKRFIS
R
>A0A376TUA7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSQFH
KPLALPCPHHSADSSQW
>A0A377EPY0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDT
ALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRV
LAA
>A0A2X7G7P8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLL
NRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCA
RKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGN
ESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377K9D7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MYGLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDV
GPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLI
FLLGLERFSLLSKSLAMDSENLMFSLFKNGKSVTGDEYNAKNAIFTVSEAMEHFSYLPTG
LYVFAYKKDVYFQVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVL
DGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNI
NDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVH
FQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A5F1Q6N2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGSNRVCASDNA
>A0A377E6H8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGDQVIVMVTRIIKKSIRKEDILGRLGGEEFGIIIKGNTQKLLLSIAERIRKNIEEQCSE
KLLSHGPEKITVSIGCFTSKENNLNPSEMLVNADKALYQAKRTGKNKVIIHSK
>A0A5I9BDB0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eko|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>K4XJI6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O111:H11 str. CVM9455|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A348AR15|diguanylate cyclase|EC 2.7.7.65|Methylomusa anaerophila|TrEMBL
MFTVSLLVLIILAASRLSRATRREEQMVFDKYQCCRDDIRHLFNLVPAPMALIRNDDWIL
VQINRAAADLLATSEGETVGKCITVFFGTNQAEYLAWTQLLRRDAPAEAELPIYRRNGVA
IVVAATASINFDGKPHLILSLTDITAKAIRTKTLEKLALTDSMTGLLNRQAFREKLVLAL
LHFREKKSELCLAFMDLDGLKKVNDTYGHREGDCYINTFVSLLRNYISENDIIGRVGGDE
FAIVFTNCSQQVAEDCIRRIQQQLNWLALHTEKPYLMQVSAGVVSVAGGAEPPDADSLLH
KADNAMYQQKYLQRRKTQPVAQL
>A0A1Q9QUI7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPFKTFFRWDLRSLILLLTLITALVTLLNSFHASYRVQYQLLIDNALEANHAYASKLASS
TETYLQASQQQLAYAANLLTRNFDDNAFLDAEAARLRLQTNTFNSIIVTNAEGLVLSTSP
DTLQIVGRKLQTEGALAALRERKPMISSPYISSTNNLIIFISHPVFDRGGNYLGLVGGSI
YLKHKSILNELLGEHYYKNGSYLYVVDANRRLLYHPDAERVGSIVGANSLIDSLADRDSG
TQRVVNSQGVDMLAGFATVHSAHWGIVAQRSTEATLDGLNDLLLSMFAKTLPLAIISFIL
IWWFSRIIAQPLKQLAAGAHKLSEPDTSGQIQRVRSWYFESSELKRALLIGLSLLHERLG
KLNHDIQTDPLTGLRNRRGLDLAVTLWQAEKRPFAVVAIDIDHFKQVNDTFGHAVGDEVL
QALAELMRGCSRDNDVICRSGGEEFFMLLPGATPEAAVRVAERLRSVVEETTFETIGHMT
VSMGVAAWPLYSENAARVFEVADEQLYRAKQEGRNRICVVLGEGVKSSA
>A0A1S7LD72|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MSVTHNFQQLIEQLPDGVVLHDRDTILYANGVANTMLELPSPLPSAVSVSQQLDPVSREA
WLHACEKQLGQPDHNQRVELKLQTQEVATHVEASLSTLILDDTPLLLTTMRDISEQKRQE
ERIRHAANYDALTSLPNRALFLDRLKQELVRANRADSRVALMFIDLDRFKWVNDTLGHGA
GDELLRETAKRLLLCHRQSDTVARLGGDEFTVILPDMARGPHAERVAAQIIEQLVTPFHL
EGQEVGISGSVGVTIYPDDADNLDDLLKNADTAMYRAKTEGRNAYRFFTQDMHAEAIARM
ELEKDLHTVVSDGALALFYQPIYDLKTNKLAGAEALLRWTHSTRGAVSPEIFIPLAEEVG
LIAEITEWALNEACRQAKVWRDAHPEATDFFISVNLTCTRCRELSTDDMIPDILKKHDLP
PQALTLEITENILSEDKERAMLMLTQLREIGVRLWLDDFGTGFSSLSVLRSLPVTGVKID
RTFVPDAIHDKEAAVLVSTIVNMGHSLEHSLIGEGVENEAQMLFLKSHGCEYAQGYFYGK
PCAADEFHFNYLK
>A0A385F182|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii WM99c|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SIWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAVCTYLSMTGVISYAPLF
NFTAMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIAQCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A168RAP7|diguanylate cyclase|EC 2.7.7.65|Clostridium ljungdahlii|TrEMBL
MRIYNLYILFSIIKINIIYGFKVGNNKLTLFRKEGSAVKQYQIVYDNFEKMQHFIYSNNI
NNSDNVLIQIFTAVIEMKFIKDLTDKITSILPKAEIIGATTAGEIYEGNVLSKTTIISFS
IFEKVRIKAKLLSDKNEYKLGVNIVKELSEDYTKAIILFSDGLITNGYQIIKGIESANSK
IIICGGKAGDNGYLKKTFVFTKEGITENGVAAASLSGKSLNITTERSFSWSPIGKLMTVT
KALNNRIFTIDNIKTIDVYKKYLGDEVTKDLPMSATEFPLIIRRNGTYLARVAFGRHDDG
SLSFLGDVKVNDKVQFGYGDVNVITSQALEMTNRLKNRNIEAIFVYSCSVRKNFMQNKIG
IETSAVNNIAPTFGFFTYGEFFTFNRSNELLNTTMTILGISEGNQTSYKNVTMPNNENEN
SSKSFFEGKDVGVIKVFTNLVNQVTKELQEANNVLEKQKYKVEQMNNATKAIMEINSHML
SSCEIDSLFEMILCKALDIISSGTMGSILFMRNDKLVYKATKGYFTDKIKEIGYKLKDLY
QYKVHDMNIKELRNPIVINNLEENLFNEKYKYNSWKKLLVKCPYELLTCGICIDGCVKGF
INIFNTDEKKSFNEDDKKLLKYLSYDIAIAFKNAQLLENILYMSRYDSLTKIYNRSYFNK
LLGEILHKARISSNIFAICIIDLNNLKVINDTYGHIMGDEVLTKFANIFKKEICEEDIFA
RIGGDEFAVVFVNKDENSVTDIISRVSQILKDYPFDLDGNKKEISFAYGFSQFRRDSDDI
EELMKLSDKRMYEKKKRMKDRRKI
>A0A718ABF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. CT18|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRIYASDATQEREKK
>A0A808XG59|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. X13|TrEMBL
MNKDFSQAPRPTFKRALRRISVISVVISMTLVWLLLSTASVFTLKQYAQKNLALTAATMS
RSLEAALVFDDSAAAEETLATLGRQGQFSEALVLDNQQNHFAVWRNTDLVRQEKFSGLIS
KWLFPEPTTQPILHLGKVVGELRLTALDSLISHFLGISIIVLTGSILLASFIALLLTHSL
HHGIVTALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRTSLHDPLTGLANRAAFRNVISTLMKDEAARRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMNFVSKRHQAWRLGGDEFAILLRDVHSEAEVKTLCTSLSSQFLEPFNL
HNGHTATLSLSIGYALAWEHASAENLQEFADQHMYRMKHRRIPQVQK
>A0A5D4XY37|diguanylate cyclase|EC 2.7.7.65|Lelliottia nimipressuralis|TrEMBL
MNKELSSTPRPTFKRTLRRISMISVVITMTLIWLLLCIASVVTLKQYAQKNLELTSATMS
RSLEASLVFNDATAANETLATLGRQGQFSVAEVLDIHQKRFAYWSWTPDDDTDTLSTLVS
RMLFPVPAAQPVVHNGKVIGEVRITARDSLISHFLWTSFAVLTGCILFAAFVALTITRSL
HNGVVTALQNITDVVHDVKTNRNFSRRVEEERIEEFHRFGQDFNSLLDEMEEWQLKLQAR
NAQLMRTAMHDPLTGLANRAAFRSSIAALMNDASAQMNSALLFLDGDNFKQINDTWGHAA
GDCVLIEVASRMVEFGGKRYQSYRLGGDEFAMILYGIHSAADVQQICTALSQQFLQPYDL
HNGHTAHMSLSIGFALAWENTSVEALLEQADRNMYQVKNQRPTIIL
>I1E2Z4|diguanylate cyclase|EC 2.7.7.65|Rheinheimera nanhaiensis E407-8|TrEMBL
MADTVNALPHFWPVLQALPTPVLYKEHSRSRILANAAALALFNSESNSSPGDSSLSLADI
QQLPLYNADNAKRYDLLHNPLLMALSGSEMQLSLLVGDSAAPDSRRCYQLHSKLVALSFT
LHSSVLISLLPAAGHAQVISGQLPATDIAELEEALAFDKLISLISTELINVQDQQLDQHI
HDALAAVGEFCHSDRSYVFQFTPDYTEMSNTHEWVRQGISSHQAQLQHIPKAALPYFFSK
MAQDYVFAVSDVSKLPAEAAAEQQEFVAEDIQSVLCCAMRSDEELLGFVGCDMVSRRRDW
TSTDLRRMKLVGDMLAKTLQNVRYRQSLQQMQQQLLAANNELTQLANQDGLTGIANRRQF
DHCLNNELKRCSRNGLPLGLILLDIDRFKSYNDHYGHQAGDAALKQLATVLQQQVKRQGE
LAARYGGEEFAIILPGSNLSACQQVANNIRQQLAQLNISHQHSDIKSYLTVSLGYCSSIP
SIQDDGLQLLKRVDAALYQAKKSGRDQACPAQ
>L7VH76|diguanylate cyclase|EC 2.7.7.65|Thermoclostridium stercorarium (strain ATCC 35414 / DSM 8532 / NCIMB 11754)|TrEMBL
MFRLNNKKVIIAVIPFIILLIAWILAMGAFAPDSGLNAVFVTVPYIFAFFAMVLSVWFQH
SRVFYAVCVLLLSFAVLSSPGKLNPAVFRNGISIFIPVIFIILAVVEERGITSRHGLIKG
LVFTGMVLFAVIDAGSAKPWLANLKSVEFMFRNDENVQGIPVISVFLFILCLCVLLARFM
VYSSNMDMAFIGATLGCFIILHFIPFPDIMSLFSSAVFLIFVIALFEASYSLAYHDALTG
VLTRRAMEQEFLRIGNRYTLAIIDVDHFKKVNDRFGHQVGDEVLRMVASCLQKYARGGKV
FRYGGEEFVIIFPKKTIKEVLPVLERIRNAVQKRPFIVRSPDRPRKKPKGKLPPGGTEMV
RVTVSIGIAEKNEKTRNRTDAEIIEMADKAVYQAKASGRNCIVY
>D4X8R3|diguanylate cyclase|EC 2.7.7.65|Achromobacter piechaudii ATCC 43553|TrEMBL
MDPILAGLSNSLPLAKTVEQLTRPLLDMLGSVTGLESTYLTEIDLDTNLQHVRYARNVGD
MQIPEGLSVPWSDTLCKRALEEGRMCTNDVASCWPDSEAARQLGIQTYVSAPVRTDEGRL
LGTLCAASARRQQLAPQAESVLKLFSNVIANFLQREILMEQLHSANVQLRSYAMTDPLTG
LPNRRALYEELERLEQRALRDSGSVLVGVIDLDGFKGINDTYGHQQGDLFLQEVSRRIAG
ALRTSDMLGRIGGDEFVLVGPGPDATEGGDAIQAALSLEERVTAATIGRYQLGDAVVAYE
GASVGVVAVDPRGLDAEAAVRLADARMYEIKRARKSARTIH
>A0A1V6BG53|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin140|TrEMBL
MHYRDKEPASSFAEYIAKVNYAKALILTFSISIYLTTLIIYYLFDRDLTVTRNRLYFFCY
CLLFIVFAVSTVVFFKVRKFRPKQIKLFNYWLNGLGGFTMFWSLAYTITDLKYNYPLPVL
SFLTACMVFMCGLILSPVFISIVFIAAWVVFNFAGSWIIYHTYFSLHLFLTSVIYIGIDL
IVMYTNYRIRRRDFEQAHILNNLNRELETAVRTDFLTGLGNRLAFDETFASIKKECSDER
IGLGLLFIDIDNFKTVNDKLGHQKGDEVLKYTSNLIKNLHPNAFRFGGEEFIILIKSESP
EDLMRQSTAICREVEKALATFVDGLNITVSIGVHFEMPPIDATSYDFINLADNALYQAKK
AGKNRAHLQNPRSEQ
>A0A378JIH7|diguanylate cyclase|EC 2.7.7.65|Legionella busanensis|TrEMBL
MRIKQSAKNSSLQQESAYLKQIIKIQSLLGQANFNLDAFMQLVAEQLQLLTPATGTVIEL
VEENEMVYQAATGILANHVGLRLNKQGSISGLCVAKKEVLYSEDTKQDERVNSEACKRFG
IRSLVVAPLIYESKSIGVLKILSDKPQAFSIKDRHILQLMAGFIASGLAHQILCEANEHI
LKERTKALKQLHEAQEKSSYLAHHDYLTQLLNRKSFDEILQRSMAHVKRHGCLLGLMYLD
IDYFKSINDTYGHVIGDKLLKAFSARIKRSIRESDTFARLGGDEFIILLEELTAEQDAIV
IANKLIKKVSDPFKFNDLTLVLTTSIGIAFYRGEEDSATKLLADADYALYQVKQAGRNNV
KIYKSSD
>A0A5C1C1G6|diguanylate cyclase|EC 2.7.7.65|Enterobacter chengduensis|TrEMBL
MQHDTFVVRQSFLQWLHKRSNPGLIVNLCFLFVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRELQNSVDRMLFFRQGMGDAIQTPLAFDVLKDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDAERIGHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTRDERTITA
SVPIYFDRYWYGVVAMDFTLSTMQQLLAEATEDRTEGEYQLYDTRLNVIATSAHAGSPVN
HFDERETAQIAQAIEHATGGGIRLGSRFISWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQYSLQWQAWHDPLTRLNNRGALFDRAKILA
ETCRQQSLPVSVIQLDLDHFKNVNDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGLYDFEQLQ
SIADTRLYQAKQRGRNRVVWRDQDRK
>A0A1R3TSJ1|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MRSEKRQIMPTLRRSLIAKIFLVSFLSVHVPLIALIIHLLSGFDTGPVPVFSLILGATLI
GTALCLFAIWRFIRPLHHLAEALMKYPQDKSVLKLPSSGADEIAIVTDAAKSMLWQVEEL
TKKLKHQATTDFLTGLGNRRWLTEQLPAAQSQAERANEPLSLVLFDLDRFKQINDDYGHD
VGDNVLMIVGEIVKDSLRPYDLASRIGGEEFCILLPRTSGEDAINIAERLRVAFEASYLD
PLPKGRITCSFGVVQAATDERLQQLLRRADTALYKAKDAGRNTVIGVFADKSI
>A0A1F2PID7|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MAKKRFDDESESCEGKIMLNAEIRELIKYLKSIVAEEKPDNDVLEKYGNDPDFIELNEMI
GGIRSACKKHFEMIFDLFPDPTIITTMEDGKLVSYNRAFHKLITTRGKNIMTGVTNIHDL
YFELDKRDQLIEELKRTGVSENMEIMVNDVNGEMFVGLVSAQAISIEGEPHILSVIRDIT
EIKRLEEEIKKLSIKDKLTQVFNRQKLDEFLQFELERSERTRMPFAVMLVDVDSLRTINE
SYGHQVGDEMLVAVAAMLKDNVRVTDIVGRWSGEEFLVILPDTDEKGAVTLAEKIRTILE
NTRFNTVGKLTASFGVSAYRKDLLPATLISRAHTARNRAKEKGQNRVEYQ
>E6XNE2|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens (strain 200)|TrEMBL
MPTIGTEKYTAEWLALVNNLSRSDAGQLEHLIHQNQHALSDTFYQAMMQDSSASEFLSND
LVQKRLKASMQQWLTDMFQSQTTEHIQALVAQQIKIGEIHARIGVPVHLVLNGARYLKTR
ITQLTSHALASHASILIDLAMEIMSQAYSNSHERNSRSEEAYRLHAIAQNIAHEKDKQRA
AFLDWENKVMFDCASGVDAALLQPLYSSEFGLWFRHKAEHAFAGAEEITLINDGINHIDN
VLLPLLALPSLQADTKKLQCLRELREQSKSIRYYLDLLFEQNREVESGRDVLTRLLNRKF
LPAVMTKEVSYSRRNKSQFAILAIDIDHFKTVNDSYGHEGGDLVLQHLAALLSNTGRGGD
YLFRLGGEEFLMLLVDINAREAALSAENIRRKVERETFLLPHNQQLQITVSIGLAMYDGH
PDYQRCLRAADDALFAAKRAGRNCIITAIDKADS
>A0A1F2PHP0|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MVNTKKDQIFTEIYMGIHCILVLVVLVYYFFSQMMTEMMTIMLIAYGIYIGFELYLLAIG
KILKLENLLGGYFQSIVDVLFISICSIYLNSFFFLVLPILCLFILTASLANDRTKSIVHG
LLATFGYLLVGILTNYFSGGVIFIQGVLLMGFSFFVGELNQLISDVYKRNHYAMEEIEYK
NQLLEYRATTDFLTDLSNHQAFYQSLEVIAEKHAPITLILLDIDDFKTVNDVYGHLSGDY
VIREVSQIIKKQLRSSDIGARYGGEEFAILLPGTGQPLGQRIAERICETVAKYPFEFDHQ
TMRITLSAGVCHSTVALNRGEQTMLVDQADEALYCSKRNGKNRVTSAQFK
>A0A1F2PHP9|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MEPAAADSLLIVGLVIAVVTLLLLFVQTKKKLTDNNAETKSIKNICDVFMNGHETAIYLK
DEDLNYVFLNKAAESHFLKLVPERINQIDPSLEAEAFESSILVTDRQVIETKKTIEYEEK
HKNRIFKVKKFPVELENDRIGVGAFIREITDEEKLIKKQERVLFRNKILVNVLSKKFRND
QKQLDYVLHEVLKLTDSNSGFICFYDEKKRQFTLKAWSKGLIKGADMMRLKQSYQLEEVG
LWGDAVRQRKPVILNNQVDKLASECGLPGGSTITGNFIAVPIFIDEKITAVVGFAGKVDV
YGDNDVYEITVLMNGVLTNVERRNIQNKLFAERSKYFQTLISIGDGVMVVDPQGKIEMLN
KVAQQLTGWTNEEAKGRHYREVFVLSHEDSRQEIADPIVAAMATDQTQELKNHAVLTAKD
GSVFHLEDSAAPIKNEKGETVGIVLVFRDVSEKKEQRKEIEYLSFHDALTGLYNRRFLEE
ELLRLDTERNLPISIIMGDVNGLKLTNDIFGHAHGDVFLKKIADVMRRVCRSDDIIARWG
GDEFVILLPKTTIEQAKQIKKRIKTEFAQDGVKLIRGNISLGCAAKTAMNQSIMECLEFA
EERMYAIKVLERDDFKSSTLDSIVTSLQSDCPQEEEHAQRVSQWCHDLGVSMELPHVKIR
RLKLAGYFHDIGKIVLHKDLLVENSNHSEEELTEIRKHPIMGYRILNAFDDTMSLADAVL
HHHERWDGSGYPKGLKGEEIPFIARVVAVASYYDRLTLAQKEASLGLEGNPLSQLEQLEG
HFDPEIKREFVNMIRNLPN
>A0A1J6X2K6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. AR2-3|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLLEKESAEFFSDD
LIQQRLRDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A8F6CMP2|diguanylate cyclase|EC 2.7.7.65|Methylococcus capsulatus|TrEMBL
MKSPSAGAPDRHASSRSVPDRWNMHKPMLCDSLPTASRTAAAILNLAQREDVTAEALAQL
IQTDPALTGRILRFANAPAQGTRRPVASVIDAIDLVGLPAVRQFALSLSLIDAHREGRCE
AFDYAAYWQKSLARAVALQSITAQASTVAPKEAFTLGLLADVGRLALATAWPEEYSECLR
KADGEALIALERERFATDHDELTRMLLTDWGFPQVFIDALQLSQQDEIRDEGRTGRFARQ
LALAQHIADHRLAEEPRRAALSPLLRAEARRCGLGDEDLARLLADPPADWLDWTRTIGLP
GDAPTGGAEPSRPPPQTDEKLHVLLADDDPIMLARLSRQLEADGHHVASRRHGETALAYA
LEHQPEMVITDWHMKPMNGLELCRALRESALGDNVYIVMLTASESEAALVEAFGAGIDDY
VIKPPSVRVLKARIRAGQRIITLHKKLARERKEIERYSSELAAANRRLELMAHTDQLTGL
PNRRYAMDRLEREWAQARTFGRPLSIMMLDLDWFKSINDSLGHDAGDQALVHAARVMRET
VRTSDVVCRMGGEEFLIIIPDTAGPAAIQTAERVRSAVEQQQPAKLKLSRPLTASIGVAD
STSAPSLKDLLLKADNALYQVKQNGRNGVRYAGL
>A0A0J1LKX1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. MGH106|TrEMBL
MEQVDPVNDTLLLSEWQALLRQTPPEVHTLLTSLTDQEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAQEDISQLLAKQRNIGVVHARIGLPIDLVNRGARKLK
DELYRVLKKKANYPPGLLSDAICFSSLAMDTALEAMTVSYSPSYQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSAEIVFLSNSDFGMWFSHKGKHILGNSNLL
AEMESLIVEIDDRLTQTLSNQQPTEAQRMSLLQDVRQLSAKMHFLLASMFEALVKQENGK
DSLTQLLNRRFIPTIMRREISLALHSRKPFTLAMLDIDYFKQINDRYGHNTGDITLKNVA
AIIYEHIRSSDYVFRYGGEEFMILLVEPDISQANIILETLRKKIAELRMVASAAESFSIT
VSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRNRVETYQE
>A0A8G0X4E6|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MTSSPKQTRSQHPLSLVGEDNGLLCTAQQGLVEPALPLTFFEHASIETIQQFIQHLTEPV
IIVNAQGYIYFSNSKGADLLTCPQASLKGQDWRNFLTEHHQARYDNLLSNDIKLGKNCGI
PVQHCAEEITLITASGKAKDVELSISYIPSHEPLFVMMMHDLTQHKAENQKLRKLAATDS
LTGLANRRYFDEMLHHYWEECTGKLRPISVVIIDVDYFKVFNDQFGHIQGDECLRKIAKV
IADIVPIDIGLAARYGGEEFALILPSHNAKMALTIAQKVQQGINDLRFTEQGLRDYVSVS
ASQGIASEINGQYRTSLAMLCAADTALYRAKADGRDRINASL
>A0A1F2Q461|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MTQFRARRTWLVLGVVVAVIVLAGSGLLSPRTSVLVDDVAQLVGGATATVVCWWTSRRHH
GVERRWRTLMALGMAGWTLGMFFWAFYRSVLHVPLPSPSIADIGFFMFPVFAVPALLSLV
RESPRREAIGPIHLWLVLTLDGLVVVGGLFILTWTTALGAVVHTGPTGSLGFLVAVMYPI
TDFVLIAMVLLMVIGPKAVAEIREPLTFLGCGLVMLSLSDSLYAYLVAIGAESMPTIADA
GFIAGPPLIALAALTKRTEPRNRDAPQQWRSDRTQLLLPYLLIAVIATIVTVQALIVGNL
DAVVVILGVGVLVLALVRQILTLLENDALLQQISAAQDELRYRAHHDPLTELANRAAFDE
HFASAIENYRLTNSDWVLMLVDLDDFKQVNDRYGHPAGDRLLVALTARLREAVPESAFVA
RFGGDEFTVLLQGPIDDAVVVAHRIVDALSSDQTADTSVSVGASVGVAQFELADEPLSAH
ALLRRADAAMYEAKRSGKGAVVVYCDRRED
>A0A1Q2HSJ9|diguanylate cyclase|EC 2.7.7.65|Sedimentisphaera cyanobacteriorum|TrEMBL
MKTGKDILIAAPRGRCWGLPENIAENLAVSESPESLQSQTKPWAKIFFILDSAADFGFTK
LAETAKNFPDASICLLGETIFEPIMQRVVDKGICSSYCTLPLTESEFSQICENGKLDSVE
SNSYEARIRKLSRIAYCDELTGLNRRRFFIESGNQILRLGECCEIAVSVFLFDIDNFKKY
NDQYGHFAGDQIIKDTSGALRNSFRPHDLLARIGGDEFAVMIWDFEIKNESLETEDEERR
HYYKHPVKSSEISKRISKNVVEVETSRGRLTLSGGMSAYPEGGRELDKLLESADSALMKA
KKSGKHTILFS
>A0A1C5REL0|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MPDEKVLQVAILIWGCAFCAIAALCIFLSSNYDREKRRYLILMESFASLLLLMDAMAHIF
SGYPGVPGSVLVRISSFLVFLLSDVVLLCFHIYVCVYLFSKRERRTLKRVKAGYVIAAAG
AVFVVISQFTHWYYYIDVDNYYHRAPLYIMSILLPVAGMFIDLTLLLQYKKRVSRKLLFS
MLSCIVLPAVAAAVQAFRYGMSLIDFSVGISMIIMFIVTMTELNQEMYQLISREGKIKER
LEIATILNKCIAELISGEDEDAAISNLLRIISGYFDGDRGYIVQIDEKRNICTNTYEYAM
NGVTAEKDNLQEVPMEMLDIWMDSFRKNGLYYIPDIEEEQGQPYYETLKMQDITRLLAVP
LNSDGKIIGFLGVDNPRLHYEDHTLLSSIQYFLTDSLKAKERKARLQYMSYRDMLTTLYN
RNRYIQVLEGMQAKTVIKTGVAYIDINGLKRVNDLYGHEAGDRLIINTARSMLAILPENA
YRVGGDEFVLICFDMDEKIFRSKVRDICDSIAAKKISVSVGVVWEESSSELETMLRRADD
LMYEEKKKYYEKHGTM
>A0A6S7EPJ2|diguanylate cyclase|EC 2.7.7.65|Achromobacter dolens|TrEMBL
MSSSSRTVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSADELVDAFY
STLLADAEAGPRLSHEIVATRLHKGMKGWLKGLLCVREQGDIAALMAVQKKVGEVHARVH
IPIHLVMAGARILKNEIAMRLRASDLDGVAASVATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVERLDDVVLPGLLQCGPASLPDQVRELQELVALIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAVNDQHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALLVAEKLGAEIRRHAF
MIPEVGALRITASIGVAAFDGHPDYAYLIDRADKALYQAKQSGRDRSVAA
>A0A6S7CGR7|diguanylate cyclase|EC 2.7.7.65|Achromobacter dolens|TrEMBL
MDPILAELSASLQAAKSVEQLTRPLLDMLGAVTGLESTYLTSIDPDQDQQHVRYARNVGA
LQIPEGLSVPWSDTLCKRALEEGRMSTSDVGACWPDSDAARQLGIQTYVSTPIRTDDGLL
LGTLCGASARRQDIAPQAEEIMRLFSSVIANFLEREQLVAELRTANTKLMAYALTDPLTG
LPNRRALYEELERLRGRALREGGSVLVGVVDLDGFKGINDTYGHQSGDAFLQEVSRRLAM
ALRASDMVGRLGGDEFVLVGPGPALARGDAAPGHEAERGDAEEAARSLEDRAAAATVGRY
PFGDITLTYEGASVGVVALDPRGLAAEEAVRLADARMYEIKRARKAARTLH
>A0A5I2WZ62|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ank|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>W7WG21|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MIVKPSRPSPPDAPLPTDGLHLDTALQLLQRAGHALSTGPRDATWLQQLVDALCDLSSRD
ALTGLANRRQFDLALERETDRVARSGEAALVLLLDIDHFKRVNDTYGHAAGDMVLQAVAR
TLQECVRPMDTVARYGGEEFAIVLPNCPPAFAQAAAERVRRAVEARTVPLPQGTMLSVTL
SAGGAFAPPWVRSSARLWTERADAQLYRAKAEGRNRTCIEPTAVSLVSAEERGMLFSPSL
PMPLDDAAATS
>A0A174AYX9|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MSITNGAAEKTVRAFLDAYLKKRDINTVLSLLTDEIQWIGIGTDGSLCGIQKVEAALKEE
YSQDPEPYLPELTNSCETSVSQDDAVFMADLTIMRPVSSGPLFTLKARISAACIHTPDGW
KIAAVHMSAPSVLQGVSGSVSQDTGEDLLNHSVFLNIDQNKQAILQNHRLAAQLEARNQI
LNIALEHTSICEFYYYPLIRTCVIPRRTCEYYHCSERYEQMPDSFLDSFVVPSCHAACRE
MYEAIHNGLGTANAEFQTLSGSWCREFMSTVTWTEDGRPDFVVGIIEDITNQKGMASALE
NAKSRDSLTGLWNKETGTRLAQKCMQEKPEGENCVLMLLDMDNFGQLNEKEGTSFANAVL
LEVADILRGSTSEQDLQIRLGGDEFMLFIRNCDKKQATVLGPHIADQVQNLMILPGRESR
ISVSIGMCSTEVVNNYSGLYRCAESTLNYVKERCRGHAACYLDTSNELGVMLTNLYTEKY
IVNTIEQEDAQRGENLISFALDLLGKSKNR
>A0A3S5DPI7|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MNKDLTASSRPTFKGTLRRISIISVVIAMLIVWLLLSVASMLTLKQYAQKNLQLLAVTVS
HSLEAAVVFRDGAAANDTLALLGKQGQFTAAKVVDSDGQELTHWQAEKSSESNMVGGLVT
RWLYPHPIRQPIWHNGKIIGEMHLTGTDATVTLFVWLSLGVLTACIVLASIIALGISRHL
HGDIDAALQNITDVVHDVRSNRNFSRRVLPEKIEEFHLFAQDFNSLLDEMEEWQRQLQLK
NASLQKSALQDPLTGLANRAAFRTKLNKLIEDTDKLRHSALLFMDGDNFKFINDTWGHAA
GDAVLIEVARRLLAFANDRYLAFRLGGDEFAMLLNAVSTQGEAEAVLKHLKEMVEQPILL
PGEQRVTMTLSIGVALAKDITSAESLMETADRNMYIEKHKQRELPTKQHQKDLS
>A0A1S8SKZ2|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MNKLFFLKKLDLNLTENQKATVINDINVTNLERMKLILIIFIIVEILFILFNDIPYLINH
SSYVIWNDSKYFILHSLNVIVSFIGIILIKLLTKYSKNKFRIMNKLLIPTLTILILSSMA
MISALDQAKPGNVSSVFIANLIIFSSIIMLRAPLNLAVYSIPFLAYLSGLVIFQNDINLL
VTNIINGFIFFLAIIIISTGVYNSNYEKIAQNIILREINTKLNYISSHDSLTELLNRRSF
NNHVSEKMRMIGKSKKIATLILIDVDHFKHVNDKFGHSVGDMVLKEISNIITKHIKTTTD
LATRWGGEEFLIFLFETSINESYVLAENIRQEIQNKVFVTDKFQIQITASFGISLLKDNF
SKSFDTSFKSADIALYKAKNQGRNRIVIASEDSNNTFNFQNAY
>A0A1S8P2M9|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MALEYTNKSRYITKKLYMLLFSLPMVLVALNITNDYHHLFYKSYTVDIADNLYIANLKPG
IVYVICVIFVNVCFIVGNSLYLIFYRKENSLYKKRSFKIMLTSFIPWIGYWIYMSRITSI
RIDIVPIFMGVFCLIYTYALFKSNIFETATIARHVVFDNISEAILVLDQENKIIDMNNIA
EKIFNIKSKLAIGQDVCTEFKEYQEIIKYIYEEKETSFNCEIKIKNKLYYFKGKLTLINN
NRGKGKVIVLSDNTEQVLMIKKLEYYGITDVLTGVYNRKYFYKIAKEKIEACSDKKHMSL
LMMDIDKFKIINDTYGHPTGDIVLKKVMNICKELLGKKYYIGRYGGEEFLILLDNANSEK
ALEIGETIRRRIENLEILHDNKCIKITSSFGIFTSVRERDLENMIKFADKALYEAKSLGR
NRVSIKMGNS
>A0A377Q605|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MLTKKKLRGREAIQYIHLSLSFLIICTVGLLFWQHYGMNNFLRLDPLNFHKVKANDDRED
NQLGRSIAKLTTTPDYWRLDCQLNPGHRVPYCSIDLDLSQGNHGIDISKYDKLTIHYRYQ
EVQEQIVLLLINFNPDYSTSNDYRSHKFNQAFLPGAIGWSTNSLVGNQFNVASWWITDKK
IPPKWTHNEFSNIREIRLTTGRHLPHANRQIDLAYIELSGKYINKDTLQLLLLLAWGGSA
ALWLAIELRRAICALQRSSERQQHLENAQKKLQEINSLLAERNMHDPLTLALNREGLNIL
LSNILPQAQLSIIFIDIDYFKKINDTYGHGIGDQVLCQLVEQVQQRIRPNDKLIRLGGEE
FILLCQGSGLTQAVKLAEKLRIWLYSNQAWPAGITFSCSFGVSERQNNELFEQALHRADK
ALYRAKTSGRNRVEIAEEANQQNIN
>A0A8F9Y4X7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MPLHVVRPKILGFISEEVSAWLVAVLVLVAGGILTGLLAWSTYSLNKQQVRQRFQLLAGE
RYSRIEERFQDQEQRLDGLRRFFVNSDLVTRQDFDGYAKPLLRRTQAYAWAPLVSRAQRP
GFEQSIRDQGLPGFSILQLNATGQMEPAGEHDDYAPVLYSQTQSPLGSPLGYDLLAQPLR
RATLERARELNGLAVSPPLQLVAVDQAYARGVLLAAPVRRAQDASGPQDRPYGYVLAIIS
LRQLVADGLPVPASDNLSVRILDLSTEGQHEVLYESNNPPISSGLTASRLLRLADRDYQV
DIRPSAAFLHANHSALGSLVILGGMLSLLLSALLYVLVSQRQRALALVEQRTEELRSSEQ
ALRGTHSQLRCVLNAATQVAIIATDLRGVISTFNAGAEQMLGYSSSEAVGHLTLESLHLP
EELESWAQSLTQRYGKAIPVSQAMLVEEGMAGGHEAREWTLVRRDGSHLQVNMLATPVLD
DQGLWIGHLAICIDITERKRVHEALAARDRLLQRLSAHVPGGIYQFKLDADGHTSFPYAS
DGLREIYEIEPQLLQQDAEAAFERIHPEDVERVRESIRVSAQQLSPWREEYRVCLPQRGV
RWMRGAASPESLRGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLQA
EMHRLERGGGVMAVIMLDIDHFKRINDQYGHGVGDQVLRGLCERIGRRLRRIDVFCRLGG
EEFMVLCPDTSGQQALILAQELWHGVRSSPIGPVESVTASFGIASWRAGEGADELLLRAD
SAVYAAKQAGRDRVLMEQP
>A0A517YHN4|diguanylate cyclase|EC 2.7.7.65|Anatilimnocola aggregata|TrEMBL
MILFVLSMAIMNIGLGYSLAVLLSDAPLISPTLVKRLLTVTSKAPKVEPAVETVPLTVAD
LPAIWHERLTAANLPPESFVEGLLLHLYLAATPYREQLLTAEVRGRHALSRLDQPAESQL
LTDVRTLHHNWRTTLDEVLQIIRQFADRLLDETPIVSQLELLLEEQLTALDRLGHDLQQI
DLAKEPELGARQILAQLAASVELLHRGRDGWQHLLGKQLRGGNQKTLPSQPLYLDSLTGQ
ISRVGMESLFHLWWAEDPQRLRLVSCALVDIDRLARLNDRLGPRAGDRILAAAAELLCGG
IRTDRGFDRLVRYSGQQFLLFFGDTGPRNAGSALERIRQSLEAVTLDYEGTELDLSISAG
IAAIQRNDTLDLFLARLNRSLQDAKLHGRNRTSVDEGEGPQLIADPQYYPVRAKCVRIEQ
A
>A0A021X699|diguanylate cyclase|EC 2.7.7.65|Shinella sp. DD12|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAENGYDALAMCERTQVDLILLDIMMPGID
GFEVCERLKANPRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKTLTDELRMRAATARAISLEEGLDSNLGDEPGDILLVDGRASSQERITRALKPIAEVT
SMSDPQAALFQAAESNFELVIVNANFEDYDPLRLCSQLRSLERTRFLPILLIAEQGDDDM
VVRALDLGVTDYLMRPIDPNELIARSLTQIRRKRCNDRLRASVRQTIELAVTDGLTGLHN
RRYLDSHMKLLIDRATARGRPLSVCITDIDRFKLVNDTYGHDAGDAVLREFASRVRSAVR
GADLACRYGGEEFVLVMPDTSADMAAGVAERLRTIVEREPFRVPGTDVFLSITASLGLAS
ALSAGDSPEALLKRADTALYEAKRSGRNRVVAAAA
>A0A1S8T7B6|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MKTVNNKYLIEQELNIEENFLNYLVLDSEKNERYILCVLKNNFTYEKTREYLLSRFRTIK
NLNFDYIVNIIRIEIIYSLNGIKLDKPQYGYLMEYVPLKADIQVYFKECTSNKKLDILME
LCAAVNTLNMQGYIFENITLRDIMLISDYKTGIRIKIKNLLQNELRKFNLLNSSVNALPY
QYNYENRNEGSLQKDNIGQVINLFNEIFTDEEIEDNLKELKHIKKTYNQVNTINKYFKLK
YFIKDINDRMHKNYKIFIKDALNKLQTDLDMIGMEEEIKIVEKNFQKILENKEKYKIIAF
RGEDGSGKSRFLQEIKYRIENKYFKDYIYVHDSEVSGGSENSIYNDLLKSFFKKADKSLR
DKYEVYIKKFILMLSDKDHSNCENKQKLQLINRIGKFINEYTMTRSLVILIDNLDQKNEF
FKLFIRYISLVSNNLENVMIVFTMNETISDINFLRYIKNLKELEQYEEYKINYFNQYNTD
KMIKGMLNTNKGINKLVVKIYSETLGNPQYISSVIKELYENKNLYFDENTGEWKTKIRVK
DILIPRALEKRLEMSLSSLERREVRVLKKMSIFEAPLSEKIILKYVIKDFEEEVYKKLKS
KKYLIDKICDQGILVGFSNDLLRNMLYLKLHEEERMEMHCKASEFMEEVLYETDYYIEEF
LLQLEKSKNYEKAYFYAIKYAKVQEISGDSLKSKMYYEKILKYPCNLGKSEAAICIAELY
EKNSEHEKSFEYFEKANVYAIQNDELEIELYTLLEMIIIKLNDITDTDTGIDYALSCVRR
LLDKIYYPKGEIYYYYAISLKYILEYNYDLALENVERAKKLCEENKIREDIYGWIITVTA
KMYARKENYEEAKKLYLYATDIFTKNNNINGQLFARLKYVELSKEEREEDEVILIKYLEL
SRLSNKHKVYKKEILSLIYIANIYRQKGKYIDAEKYLLKALEREKEEGINFYSFNICNEL
CMIYIKSGKINLAVKYYNMIRQMQKAIKLPEEQIISFNYTYALYNLLVCNYDMAYDYLKE
VYGLIFNTNNFYHKVMICKYYELILYKCKCDEDIKNVYSKLNNKIELLNKPDVGLEIRLS
AIKRILNLGYKELAKELFFKIKEYPRDYNVEGVYIYLEFNLKDKNCYNFLINKALKVCAF
ISNQETKADLYAAVGKKYNELKCYDLAINYYYEAISLHMDVINSLPEYDKLSYINNSDLL
KLRSLFARCLNYDLNMRISFKETHFIKNTEEISRILMELNLENILKNEEFFKLAQSLYEK
CYYNDLNDAFKVFEQFSGDTIKNMENIIKYISRLVLADKAMIITESNEGGNDIICTYRIN
DKNEINKYFSLKVDTEEDVFIICNNDTRFYQLDNKILKDGIKSCMYMKIINREETMNNRR
GVNARLILIADNAINYINNQSKIIIEKFKPFLIFLLEKYYLTINSALDKLTEVYNRKYFE
EVLLFLLDKEKLEESKFAVMMFDIDDFKGINDTYGHQTGDEVLVRLVKEVKKCIGKDDII
GRYGGEEFIILCPDINEDEAIRKAENIRLNVEEAKILGDKRNVTISIGIAMSVNELLSSD
EMIGRADQALYKAKNEGKNRYVLWEKEESISRNINNELAGVLSGNMAKDYSFALDLKGVA
NLVKYKGDKIDKIYIFISKVMQVIECEIATVFEVKDKKIINNYSKLRNEDGWYTTEKFNW
NLIYKVIEEEKGMYLIDWETMGNYNQYGMPEWKSICIVPIVCNGRILSVVYLSIPVNKKE
FGCNEYNLLNCFAEVGTPIFLT
>A0A3Q8DRP3|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. CFNIH10|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>Q320S8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSALIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNHDYLLSTAHNAIDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A8B4DYR8|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MVTTYPGRNGFGSESNRCSAGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLA
ATGMSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVA
FVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTML
LANLFAGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVV
VVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPDI
DYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAK
KAG
>A0A379A6Q7|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MAHSGAMFRAWWRDPADYAWLARALDSYTAVAWLKVVVGAGGVFLAGIALLAMSSDGGPP
NDFGLAIDWIIAGFAVFWALRWWLLPWPSRVESLLLFGAADVAITVANLQESNRLYGALG
LTLLVITGGYLAVMHNAKVLALHAVWTVFSVVLLTGRMVAGGGDPMIGAAIVLMTAACGV
VLMPAMQFCFWVLRQDAVRDPLTTLLNRRGLELYLAALAGSGCRRPVYAIALDLDRFKDV
NDRFGHAVGDEVLVRTAQRLRAVLRAPFVVARTGGEEFVIFGRITERTAQAEAERVRLAV
SEPQAVCAETGEPAETISVTASLGVVVYEGTCDSALPYSMLRRADDLMYRAKQLGGNLVV
TDELVASAAT
>A0A0T9N7U7|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MNYNQSAHNLKIADLNERVVHEILEVISDGIWDWNANNGFVYRNTGWYEMLGYPAHAFEN
IVHTWEKIIHPEDFERVMFQFDAYINQQAEKYQIEYRCLTHDGDYIWIEDRGKVIERNID
GTVSRMIGAHRNIHDRKQRLEKLELKNKSLEALVEERTAELRESNFQLQQQLDIEKILSE
TDVLTSTANRYLLEKVLKHEYNRAKRFCQPLSLLSLDLDNFKPINDKYGHSVGDLTLTHI
VDVISNNIREVDLLGRWGGDEFMIVLPNTQLNEAKCIAEKIRHLIEIMPVDGDIHITMSL
GVVELEQKESQEQLLIRADKMLYNSKAAGKNRISG
>A0A379BN81|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MTDIRRIFRAWWRERVDYRWLVETFASHSALAALKLMVGTAGLVMMAITLLALVSHAGQA
GPVGVTQAIAVSVLAGLWTLRWWLLPWPSERESLVWVAAIDIGITANNILVQDRLLGALG
IVLLATTGGYVTIFHGPRILAWHLGWSLLSIVLLAVLLVIGEPGDNAHATGDPALAVGVV
LANLAVTGVVLPVVQFCHWLLRLDALSDPLTRLLNRRGLDSRLAQYAHRGRGGPVYVVII
DLDRFKAVNDTAGHSLGDEVLVRTADCLRAAVPPDAVVARTGGDEFVVVGTLRAEALEVL
AERMRRAIAATDTLPIPITASIGTAVSDQNAVTSMRDLFRRADSAMYRAKQLGGNTVIAG
RPDGAAQMVLD
>A0A220WAW7|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. SMR4y|TrEMBL
MRLFVAFLAFICLSSPAFAEVPMADRLCTQSSALDVTAATLLKSGKAFDCSDNKYAVEGP
RVWVKIPFHADTLPAGTIEVQGDNNGLTKMQVHAILDDGTILSSRLSEQQVIDSWRPKGH
YGLAIPGTENPDLRNRITQVYLAIDNPVVASSMSLIQLASKEKWDDLKLPLSIMFGVLCG
MAIMPLFYHIFFYAALRYSFMLWHSAMIAATVVYTFSSSGLMFLAFPSTSLLTKMLLNYW
TLAIAVAASGFFLVRFVEQGKIAPWLRTGIIASSVLPVIVTAFVLRIDDGYDMDARNYYH
ASFLPAFFIVLYAMGHALHRGSKAIWFQIAGWTPIVLFGLDRVARGMDLYIGWPALDYGL
YFALVLETIILALGVANRIWHLRQRHENTLRKQVELTLLADTDGLTMMNNRRSFEREFRR
NQREHRYSHLAIIDIDFFKRVNDRYGHEIGDEVLRVVGRQLDATEHFAARIGGEEFTLLI
KDSGRQKRKSYPAKALTEICEMLIRTVHEEVPEIREPVTFSVGVAAIGRRASLRGTMATA
DRRLYDAKNNGRNQIVWIDISPSQTETPAGSASV
>A0A5P9EF48|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MQPVDEGWQYRWGDSPFLADGTPLWLDEPDSAEHWHDIAFPSNPPGRKGQEHAWFRVTLP
DGEWYAPALYIYSVDIILQVWFRGELLYQYGTFDEHGRGKFEGWPWHEIPLPDGYEGETM
YFRVFSNYTDIGLWGEVAILDHPDLVLHIVGNSAESLVIAALSGLIALLALVFALIQRGQ
RSFASIALFAFLTGVMLLAESQASLLILYQPLLWDYLAAGSYYLIPVALALLLSQWLDAR
RPRLVRWLMWLHLVFAALALMLALLGLVNLSSTFPVFDGVLLISLALMVAVVVRNFSSLY
REQQVFLFTCGVFIVLLILDMAVAHGFLPWGRVPVSWGALAFSLALISISVWHYGKTQQA
LHQLTVQLEQKVAERTARAEALAEREVERSRLLALESKKSQKLADTIAALQDCAGVEEAF
QPLLQALPQLYLPIAGCFYRRNPGGGYDRASLWGRSAANIFPPSLTQDLSGLTETVLPVR
SQDVPAQLCFLLRVEPAQFGNVPEGVLLLERPNLPDVVKDYGTARVVAWVYQSVEKIGIT
LSGLALRSELQRFSYEDSLTGLKNRRYFDELFRHEREVAIRSERPLSLLIFDIDHFKRFN
DSHGHDAGDEVLRMVGRVLENCFRGSDTVCRYGGEEFTVLMPGASREEARQRAENLRVTI
AESQVEYLGKQLGNLTISAGIACWPESSPEFDELFRAADRALYQAKAAGRNRVVTASV
>A0A2A5PKH6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. YT-02|TrEMBL
MYQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSSSEQVQTITEF
IYQVDELIQKIGQCESQAQAIEMIQSIRAKNREILHLVDQIFQVSEYISSGNDALTQLLN
RRYLNTIVSREINFSRKNNSPLTLLAIDADHFKSINDRYGHAAGDDALQFLADVILQYAK
GSDYAFRIGGEEFLLLQIDTTIDRALVVAENIRKRVEKATLKTSTGEEFNFTISIGVHEY
DGHPDYQRFFEEVDKALYMAKNNGRNNVSVG
>A0A2S9ICL3|diguanylate cyclase|EC 2.7.7.65|Pantoea coffeiphila|TrEMBL
MSLPTESRFFHPKNIVHLCFALVFLFLTLLTWHEAMVLKRTYESNQLARLSSVANNLDNQ
WQHNLDELAFFHSMLEHSLGDPLITDKSTAFLQQFERVRHTPLWHLSPSETRGIPINGIS
DELLTRFPLFSRSDSLRLADELNAVLEMSQILQFNQPERDFHYRFWYISRAGFYLSSTLP
DASSNHSLENFSGVAQRPYFVDLDPKVNPQRKILWSDPYDSMDNEGKVVTVARPVDRDGY
WYGVLAMDFSTQQIKQYLQQSLSTRQEGGVMLVGHQFNLIAWSDGSQLEEYRLHKAQLAQ
LTEQAAGTHSGTMRFDGRFVSWVRLQYFDGMLVNVQTLREGLLGDSGRVGLVLLLTWLMF
SIVVLVSHQTIIRMTGSLLNLQEKLSWRANYDGLTRLFNRTAFFDRAEKLAALNQRQRQP
LSVIQLDLDHFKSVNDSWGHHAGDRVLAHAASVIGQALRKTDIAGRVGGEEFCILLPATR
LDEAVLVAERIRRKLAAKELLVGKHQTLKVTASLGVSSSEEQGEYQVDNLQSVADRRLYL
AKQDGRNCVRHRD
>A0A5I0ZPU1|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASLGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V5NPX2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin373|TrEMBL
MRLSQEEYKLIVDFSPNMIWRAGLDAKCNFFNKTWLEFTGRTIEQEVDDGWAEGVHPEDY
DRCLNIYLTSFKERKGFEMVYRLRNKEGEYRWINDIGIPIYHDNGDFAGFIGSCVDVTDR
VEGERLKKAAQIDGLTGLNNRQHFDTLYIDEFEKAVRYKTSLSVIVFDLDEFKSINDQYG
HFVGDLALKHLSRIIGQTIREHDICGRYGGDEFIIVLPHADAEQANLVAERLRNNLATNP
LVVEEQSIKLTASFGVVQFTDNIGNALELFKLADKALYQSKQKGRNQVTVNSDPFPSI
>A0A8F9MTQ8|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MDKPLWVRKLHRVSRPGHVVNYCFVAVLFFSTLLIWREVMVLEGAYVTNQRNNLENVADE
LDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHEPIWSVALHNRRTLPV
YGVSDDFVDSQSSLSRNDALTGNELMAVLELGYLLRLVENNRGFNERMLYISRSGFFTST
TLPKNAVQAQTLYTHAIAAPWFTRQSQRNNPGRGVFWQTVLDEHAQNDDPVVTASIPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIASSASGNVLTLLSAREQ
AMLSYAFLHQNQGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGAFGTITIALTLMWL
LFTLMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFERAIATTRMCERTG
RPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQVATAIAERIRIRIYSREILLCNDTSLRISASLGVSSSDACAGFNFENLQSTADHRL
YLAKQNGRNQVCFNDLPSCAGLRK
>H6RKA7|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MFSAPGPSGTRPPVDREESSQVSAQAASSPQARASTEDEVGLAHTFVQAVDALLCMVDAD
GRILLSNPALQRFTGVDGDELRGRRFWDVWVVPDDVPHAQEHLRLAVASGRHFAEEADWI
DARGDLRRVSMRNTVLFDDDGRPFAVACVGIDVTEDRAREARLRQQTRTDLLTGVANRGA
LFDALRARLEASECGLLFCDLDDFKTVNDRFGHGVGDQLLAEAATRLVEVAGPDHLVARF
GGDEFVILSMAGEERELAELSVRVVARLGMPFPGPEGPLLIGVSVGATVCRAGETADEVI
ARADRAMYGAKSSQRRRASRD
>A0A811G9P9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MTWKNICDQYTEAEHQTALNFIENHVEHLVTVFYEHMAKEPESAEFFKDDIIQKRLIDTL
RKWLLETFHVALNAEYDKSVKRQQKVGMVHARVGIPSWLIMRGVREIERKIFEILEKKTE
QNNLHLCSYIVQIMGFSTEIMCRSYEANTEKNQENKHNYRLFSAMQDVAVHKDKQRGSLL
DWENELMFKIFSGKLGFYHPLFSKSEFGLWFIHKASYAFSGSDQVQLIIDRIYKVDALTQ
QTMQILEKDQVLVLIQSIRELNREIQHLVDQLFQVAEYIESGNDSLTQLLNRRYLNTIVS
REITFARQNQTPLSLLAFDADYFKTINDKFGHAAGDLALKFIAEALQRYSQGSDYAFRIG
GEEFLLLLVDTELCRAMTIAEDIRNYIEHGLIRTTQGQQFSFTVSVGCVLYDGHPDYQRF
LDAADHALYAAKNNGRNCIQVTKHLSSV
>A0A385N851|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. WCHA55|TrEMBL
MNDQCMAELAEQWGKICQHYSVKDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKKSLNQWLVESFDVAVNETYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPRDNNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQNHKIERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLGVA
KGSDYAFRIGGEEFLLLLVDSDLNRALQVAETIRMRIQETPIRTTHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCTHVTEKVLSV
>A0A7Z9CT56|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MKTKKKAAASSNVLRYIWGSALATICLTTILSFWLLSGSWSMWKSAHNNVIQFDIFYRVL
QVSNDFAGERAFVNELVLSPLADKERQWQALEAHRRVTDRDMQSIPRHLLSPELMVEMQH
QLAHARRLADTFRSRELGDPATAEHAIRDMVVATDFYHQALFERTAEFLLLEPSALGPIL
RAQALGELRDATGRLGSQLLIPLATQTKIPQANREGITRGIERINTAWWLLQTQGDEASY
IPHFQRQLENTRQAFETQGIGLINRLKEESDGNQPYSISAERFAIDYHASLGAFDNLLNT
YMAGVKKHYTASERRALQSLLIRSLVLALVYALTIAMIFYIRSRVLRPILRLNNIAADLI
AGKQAHVQIDDDTAEEVQELFSSLGTLGKKLREDARISRQYQRQSEEDPLTHLFNRRAFN
SRGEALLRQSSEALSAWLIMLDVDRFKSINDSWGHPMGDEVLVALAKTLNKFSRPSDVVG
RLGGEEFAVLFLAPTAQDVASYAARIQHEIRKLTFHTSGGETFKVTASFGVSQGWQCPLE
ELLSRADSELYKAKNSGRDRICGLP
>A0A378HH17|diguanylate cyclase|EC 2.7.7.65|Levilactobacillus brevis|TrEMBL
MTWSHWFVAPAITSFFFLLGVLTLYWFLTNRIVRLLQKFGYHPDPEAVRNIFGLLYMIVI
IFGLQLSVRDSANSWVFSNFKIFAVVFVSYFLLMDIHWWETLGTILIYMGINGTLGIPLS
WIYAGVYVALFYVMKVMRTRKQDHWTDYFRFIIPSLILSAILWALIGFRFHLTTTNILWE
MLFIFLLLSMMYLYVDSLMTGAATLARLTYTTNFDELTHVNNYFAFKNDFEEQFAHSRTT
DQPLTLMLFDIDHFKQVNDTYGHLAGDYVLSHTAQLVTKQLGELDDTLHLYRTGGEEFTI
LFTGYTTEQAAPLVHSIAQRVREAHFSHDGHQISISISAGVTQLHTDDDQRVDIFHRADR
NLYHSKQTGRDRVTIQ
>A0A399DX37|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MSLTPDDARRQLSLLTAALEELPLFAGPRALLEGLPALFARQGEGHVSVWVPEDSRLRVL
AAWGFDPQALPYLAEEGVVGRAYRQGEPVYVADVAQDPGYIALEGHAVTSELALPLRVSG
EVVAVLNLERPCPFAEAELEGYVRFARAASHQLTRLYERLQFELTSRLGEEVGQAEDFQD
AARRALDHLLPALGGTTGAILVQQGGLLRAVALAGEGLRQGEGSLEEGIPYGRWLSWQVL
SSGRPFFASAYDRSACRLEAFKAAGTRAMALYPIPLGPHARTRALLALGDSRPRRWLRVE
REVLAAASRTLGLSFATFQTQERLATLLALAREAVEAPPEAVYQRLVEAAVRLVPGAQTG
SLLVREDGGFRYRAVVGFDLTAFAPVTLTEGQQRAWYGPDLEAWRRGEPRILALGADSLA
AWSRGSGMPPGFDEFTRVREIASTLALPVPYQGEVLAVLNLDNFHDPAAFDEDSLEAARL
FVPPVAALLHELDSRRRLEMAALTDALTGLPNRRAFDRFFPEELARARRYGYPLALLVMD
LRGFKRINDELGHATGDQALRRVAQVLSAQRRGGDRYFRWGGDEFAAILPHTPRGGAAGA
AERLAGHVEAIVLEGRPLGVNVGVAAFPEDGTDEDTLLSTADHRMYRAKTHGVAVWAQ
>A0A839WCF5|diguanylate cyclase|EC 2.7.7.65|Atlantibacter sp. RC6|TrEMBL
MSDFILSRISETLASENSLEGLVRKLLETLEIVTEMDSTYLTKIEAEQGKQHILFSRNSK
EMNIPEGLSVPWGDTLCKRAMDEGCLYTNDVASQWGDSEAAKALGITTYVSTPVHLDDGT
LYGTLCATSADKKELSVRAEYVLRLFAGLIAQYVQKDSLLEQLREANAALIAHSYTDALT
GLPNRRALFKNLDALFSLARHRERTVIMAFIDLDDFKEINDLHGHETGDLFLLQVSDRLS
AGITQDDIIGRLGGDEFLVAELGGKTDEAQEKIAFALKARLNGLLEGKYILRDLELNYAG
ASIGVYVAQPTQEDPDSALRKADANMYLDKNARKQH
>A0A399DW46|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MTGATTLDREGFYQTLASWKEDGPISVAVADIDEFLAVNQNYGRDVGDAVIALVMKALAG
SLPPGSLLTRIGGDEFACALPGASPEEALIQLEEIRQYLAGRKHNVGEVSLAVRLSIGIA
SFPRHVSDPQQLLQAADEALLRAKREGRSRVAIYVEDKMVLKSNYYPKNQLARLATLSER
LGRTEAALLREALADLLDKYREFL
>A0A399ERD5|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MEWVGGLLLGALIASAGWRVAYLRVLGQSCTDFLTGLPNRRGLERALARELALAERSGEP
LCLVLFDLDAFKRVNDTFGHAAGDKALRLVARAARERLRRSDWAGRWGGEEFVAVLPGTS
LLAAEAIAQRLRKAVSVLEPVPGCRLSISLGVAAYRPGESAAELLERADALHYRAKRAGG
DRVCAEGSGLELDDVARVRG
>A0A1S8LPZ1|diguanylate cyclase|EC 2.7.7.65|Clostridium roseum|TrEMBL
MNLLSLFSYGNFVLFLLLSIYSIQFSPIRSKLNKYSFWVCLALGEWNLCYVFFYIAPNSS
TALIWHKLALIGMYCFPAFTLYFFIVLTKRDTIFKNKYHYFIFYLVPAILILISLFSKNT
ALVQALVQSSSGLGWTYVNSTNSILYWVTLLYLYCYFYFAFFLLYKWGKNSNYIGEKKQA
RIFILVDATILMLGSITDFFYPLIDNFLPPMANLFTIVFILFFIYIIRRYNMFDIHHIAS
PELIINTIMDPVMVLDENFKIIRSNPAAENILGYSSSYLKNKNLVEFLLGNTDINNKILM
ELLETKEFKNKELNVITSKGEIINSLFSASTAEDRINGFLGIMITFKDITEIKVIEDNLK
FVNSKYRKTADKLYKIANFDPLTRIANRRLFFENIKQKIKQYEQTGKDFGVIFMDLNGFK
PINDKFGHNIGDKALIESVCRLKLCTYDEDVLARMGGDEFVLIVSDTSSINERINKIKTL
FLSPMHIDGCICNLGIAAGTSIYSQSNRDLDELMRIADILMYEDKKKSKVK
>A0A517W9Y9|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MHPKTVLKDRVRRHGIPSLWCLLLSGITTSAFAADPASLTTTTPSGPGGLSALNEIVLVG
TCVTIPALVLIFLIPAVLRQRSTAQRAAKLQENQQRNDLALEAGRSGIWELNLTNNRLHW
DRQTRDLFDVPPEETELTFESFRKRLHPEDRERVETEFNDSVDAGTFFSCDYRVIYQDGS
VHDIHTQGRAIFDEIDKPRLFIGVCHEVTERRMPQSMNSPKGPESEKLLNRVAMQNRLAH
LSALTKELSREARFSPDRASLVKDQPKMIAGRISSSDGPLSSE
>A0A654BU87|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MKLRLGNKLTVLLCMFGLLLGGIASYYSLSSSKQILIAAAKRDLLLANQVLGRNLQISLE
NFTRDLKVLSDQSQPVEVLQDMPNNSKEVEELARLFTSMLDAHPEYQRIRLIEAKNYGLE
RINVDRQGIVTSTALQEKGHIPYVFKTLKLSPGQQFFSEIAPSRLDPDKALTLHIASPIW
TNEPRAVGVIVLSIDVKTLFSRLKRELPDYYQFFLANSQGELLLNPEREQSQDQGSIAML
QAQLPEILTLLSGKSSSMLGILPAKREQPSRLAAFTTISIEAESNHLLLGLAVPEKHILQ
ASQALDQRLIQIIAALGLITLILSLWLARQMIRPLNQIGLAIAHFSQDLSLQPLPTERAD
ELGKLARDIRAMQEKILAQIIQLNTNQQELQRMAHIDPLTGLPNRRLFFDRLEHAISNAE
RSGKLLGLLYVDLDHFKEINDTHGHAAGDEVLSNVAHLLVSVTRSGDTVARLGGDEFVIL
FDEVESRATLLGIAQKLLSLLQNRLLIDGKDLQVRASLGISLYPHDGSDAQTLLQNADRA
MYSSKRSGRNTITSSHIT
>Q88DZ8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)|TrEMBL
MKPTRKRTVRPTLRSVLGRGHLSVALLAVGLAGISLTLLGVLALRVYANHNLQLIARSIN
YTVEAAVVFDDSAAANESLALIASTEEVAEAKVFNNEGEQLAHWQRDNTGMLAQLEVQVA
SALLDEPVILPIVHQQQQVGHIELAGQGRSLLLFLLSGLAGILFCTVLSALAAQYLSRRL
LSDITRPLRGLASVAHAARRERSFDRRVPEAPIAELNELGNDFNALLDELEVWHSHLQSE
NQTLAHQASHDSLTGLPNRAFFEGRLSRSVRNAARQQDHLAVLFLDSDHFKQINDTLGHA
VGDEVLISVAERVRAQLREQDLVARLGGDEFAVLLTPLHTRKDAEHIAEKIVASMELPVQ
LDSGRSVSTSLSVGIAYYPDDGADPASLLNAADAAMYQAKRERRGHWQVAQTERSANEIR
NRS
>A0A5E4Z636|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrae|TrEMBL
MKSTISRTEQGNRVAAASVLVAGCALTAAGFMARAIDGPVNPLLTFFLVSAAGILNLSTA
CLLGVQFLYNGKRYFAQFGCAFLLRGLLMFTQGVLLANQLAGGEDAVTRAPFWLWIAGET
GFAGYVWLSARSYSSTCQDPHKRPGYREAARHGVTVLVVWFAVSMSLVGAGKTMSAPAII
GGANVERFAGVGLLVLYMALWLYVAALTRLSHKLFLLVWVVLSLALCEVLLSLTAPGETS
YPWYVARMLALASPGVATLALMWEITRQYQSLALTNTDLVEKVFIDPLTGIYNRRYFDSR
IRLVAERAQQNERPLSLLIIDVDFFKQVNDRYGHPFGDAVLQRIAATIQHCIRTPRDFAV
RLGGEEFAVVLPEIDQHAALRVSDRIRESVKRAGADMLPKQAHDDGEAITISVGIATWKP
GQPFIIGAMLENADQALYEAKHKGRNQSVLASMPA
>A0A0E1M0H2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1303|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6M1ZP40|diguanylate cyclase|EC 2.7.7.65|Chlamydiae bacterium|TrEMBL
MSRSKITILLIEEDVENANLYKKFLKRGEMGGEVTHASTMEEALPLLSQHSFKLIISDLF
LIDSSGLETFHKLRKAAPDTPIVILTRPVDEELAQETVCQGAQDYLPKSEITTQSLNRVA
RSAIERHELRESLKALSFTDELTGLYNRRGFMTLTKQHIDLALRQKHGFFLFQIDLDHLK
EINDTFGHLEGDKALVKTADSLKKNFRISDIISRIGGDEFAVIALNVPEEKGHLLKNHLL
EIIREWNATKEQPWQLSLSIGTAYFDPSKATSIEKLLELADQEMYADKKIHHEK
>A0A174C9Z7|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MTNNRLNIGIFTCHIDNDYATEVCKGAEYAAKELDCNLIVFPGMFLNASFYDPANQLYDY
QYNSIFYYAHPECLDALIISVGAISSLLSEKDMNSFLSHFDGIPILTLEEKLPGYPCIRT
DNSKGMRDAIEHLIKEHKRKHICFVAGKEDNTDSNLRLKIYREVLSENGLGVEDRMIIHG
DFAEYCQEETAQLLDANPDADAIVFANDHMAIGGYAELKARGIRIGETMSVIGFDDSPSS
VNMDPPLTTVNINSCELGFRAVYAAVRLAQTGNMKSEALDSRLINRVSCCCHLCTESDLM
KDGRHLLDLDIPDIIDILDGRLFGEIADSFYASKVMSAYNRILIDIVSVIKSDIDTEYPQ
NKIIDELKCILESDLTDFYSVQKTAYMFRELASIFSSCKLSAAKSLQFNRLNTTITNTIS
LFISNQLYNTIYENKMMGWSSIYITRDTLTYGEDLGKTYTSILHKLQGLNYEGAYIYTYD
DPVRITDTGSWIVPKSVFLQAFFNPNNCQVLFGESRRVPSIEIFDNEYTYYDKRFTSVIV
PIFTNEDQHGVFICNTDVAHFSSIYSTSLQLGAALKYMSLLREQNITQEQLRMSLNEIHE
KNELLNHLSTSDELTGIYNRRGFMERVEYYINIPSNCGMKAILLFADMDSLKVVNDKFGH
KDGDFALKNIANILSQSFGPHDVIGRIGGDEFVCFAFIDDSDYVTEVQRKIKDFSAELNA
TCGKPYFIEMSVGVTEFVCDGEQTIEDLLSQADTALYSNKRYKRMSILK
>A0A8D9P3Q5|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MNDINKDEIDARWHMLVWRMMIVICSISFVIAWILFGVYRVDKSIGAGAYIVKYIVLPMI
VQAIAITICYFYMKHDEADIKHKNYVVTGMIYVCVGVIAFTYCTIYPLILIPCVTIIATA
LFADQELTVWSGVAVLALMVINVVRLHLNVGELATQMNWVGALLIYILVVSVMCAMVMVV
NKHTKALMESIAGSYNRQVTLMSELMVDPMTGLYNRRSFEESLDKEIENVEQTGAKSYVT
IFDIDHFKEVNDTYGHSNGDIVIKALCKMMKEKSKDMGLAFRYGGEEFVILFHDVELSKV
MNVVEDIRTEFRCYYFHFMNKDGITCSCGVAEYTKGESSKAWFNRADSALYKAKESGRNR
TVISE
>A0A174CVE4|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MNRTSDMKKRLPGIILITGGIVLVAMVIQAVILSFINNRSFDRTSQVLLDQVSNVIEKNK
ASEEDLIDSLKEDYMVRAKAVAYIVDAKPEVANDVDELRKIAALISVDEVHLFNTDGVIY
AGTNPEYFGYSFDSGEQMAYFKPMLDDKNLTMCQDVTPNTSNGKKMMYAITWNDDGTKMI
QVGIEPRRLLNEVKQNEISTVVANMPMYDGLSVVVADGESGEIYGCSYEPVVGLTLDEIG
ISVTDDMLPDDEDSFTGIRRINGFRNRCVFRRSGEYVIGVIYRMDVNSRSNMAIMVIMAL
YLCFAAGLVVSMVMKVIHANRERNEQLSILTSMSGMYYSMHMLDLQHDTFALYTAGDLIL
RAGERAAGAKELMRKIVHKVVVDEHQASAQKFMDLDSLGDRLIKKKIVSGEFMVKDLGWF
RLSFISIDVDEDGRPLKVIFTTRNIDEDKKREQKLIRRSYTDELTKCYNRSAYIDDVREL
PGDSVYVYVSMDVNGLKPVNDTLGHAAGDELLQGAAECMEQCFGNYGKVYRMGGDEFAAI
IFVNTRRLKRVQQEFDDVVRGWSGQLVKSVSISCGYVSSDEKDWESFDEIVKAADERMYE
NKAAYYRQKGGDRRYR
>A0A1V5Q0W5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MSKKGNRSISLRSINASLIIVVVIMSGMVLYAAFHLASSFEHLAEAEKQHYAMGKAAREL
MDASDYLTENVQRFTVSGDRKFMDLYFTEAFETNRREEALEKMDNGKNTEEAFKKLQEAM
DNSVSLMDQEYYAMRLVVDAKGYTDHNEVLDEVILSPEDAALGPEEKIKRATEIVLSDEY
YEQKSAIRRDMQESTDRIDKLMDEIEKEEKDALNRRVKMVYIVLAIQFISILFILGLISH
LGIKPVLTAVEKIKSDDPIPESGASEFVYLAKAYNKMYQKFKNSLEKLNFKASHDVLTGA
YNRVGYDFMLSNVDLKTTCLMMLDVDNFKSINDTYGHEVGDKALIKIVKVLKGVFRDDDC
ICRLGGDEFVVFMVHSAGMQRSLIESKIKQINRELENTDDGLPPISISVGIVNGKDVTDT
DTLFEKTDEAMYESKKKGKHTYTFYQE
>A0A0H2LZV5|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MRLPFPILPRLSLRARLSAGVLAIVFLTTMGITAAALYFVKRNMQAAIASEEFERISAIA
DAMDQKFLSRRTLLKTFGDGVESRNLAGAEGLQDLLMQHESLREAFDNVAFTGMDGELVA
NLNGTQPIGKVNIKDREYFQRTVAARAGIISKPFRNRVSGLAQIAMTEPVLDRGGNVAYV
ISAFVNLKEQNFLGELSNVKFGKSGYMFIANTDGIVIDHPDKSRLLQRADAGGGRNAATE
RAIAGFEGTMEAVDRAGVHGLYAFKRIRQTNWVLGAMYPRDEAFARIEQVERYAWAGALL
LTLLAGGLAFMTARAQLAPLSRLREHMQVSRAATAYAPMREAPPDDEVGDLSRTFDLLMM
ERQAANEKLAASERFLRDVTDNLPAVVAYFDSDQRCLFANKAGLGMRGRTPADIGRMTMR
ESLPDHVYQQLVPGIAKVLAGTPTRTEGTYERNGKQGFFECHLAPDIRDGGVLAGYYVMT
FDVSKRKQAEMHSAGSERRLRGLTDNVPALLAEVDLEERVVFCNGKYQAWLGVSPDAMTN
RPIHEALGEAHYEIRKPLLARAFAGEVVSFEQTASLLIGERTLQTTYLPQRNAEGAVTGL
YILSNDVTELKQKQMKLDALAREDALTGLPNRRSFEEHARDAMARSRRAGLPVCLLFLDI
DYFKSINDSLGHAAGDAVLREFGRRLKESVRETDMAARYAGDEFVILLEGVTGAAEAQVV
AGKVLAAMRPAFHLASRTLQATTSIGVAISEEDEDLSSLFVRADTALYAAKKEGKNRFMM
AAPRPANPGGASWPREKPSSA
>A0A0T9UIJ7|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYHADEIIGQSFELF
YTPEDLATQLPAKGLLHANQLGHYENQGWRVRKNGKRFWGHITLSALHDSDHNLQGFVQV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
MGYASNEIIGQHFGCFFLPEDIAAGLPEKLLKTSASASRVEREGWLVRKDMTRYWAVTVI
TVVHDHHGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEEVFILWSPLQDKNQLVAINQCLAEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDDLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAISQLGQDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCQNKPATEVLERVVADIASIQFHWHGQSYSFTASLGAVSL
NRQTETAAQAMRQADIACYAAKHAGRNRLSLAL
>A0A1C7FAA4|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MVRLGLLRGFILAIVSVFATCCLSVSAYANEQYRVAIEADDVVTRVLFDAVSQRFEVDIA
YVYYPSFNDILTAVESGESDFAANVTYTPQRAERFDYSSPTNIEYTYLYSYTNATLETIE
RVGIPKGTIYGELIKKYFPSLTQIEYSGHQQARHLLDSGQVDGVVDAINQLKPMLLAGLD
AQLLNHQISIKPVSLIGTKDKFQSQLKSFEQHLHSAPVQKLLRETVNQYQFDIRQKSLRD
LVLESGIDRNRPIKVKIEHAGQYATYHNDGQVTGITPDVLFSACDILMLNCKLVSRGDET
WEDMYADFLAQEIDLISPFAKSEPRKQFAYFSVPYYQSTAIMIKREGYKNNVYSNVSELI
VERIGVVKDDFYQELLESLLPQKTLITYRNAEQQIAALLAKEIDYVIITRSSYNKILRES
KTLLPLAEDKLIGEFYTSNVAIGFTKNARGKALVPLFDRAIKMLDLEKITNTHYVQPDWK
AALQSEQRLARRSIAVVALGLIGSILVSLYLHHQSNTDNLTRLKNRRALQRRYSKDISPH
LTLVYLDVNNFKPINDTFGHEIGDQVLKHIAKQISRYWKGQSYRIGGDEFILIGSVDSVT
LSYALLNLQKLQFTSQDHRITLDVSVAFGVSKPRREAMTLEDVMHQADLSMYSHKRKVTE
REINVAKQQIEQELNMIQP
>A0A0T9MPQ6|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNAGYAAEEVIGQSFELF
YTPEDLANKLPTKGLQHANQFGHYETQGWRVRKNSKRFWGNITLSALHDSDHVLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGVPEKSLAQATTEGNYQSEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIGQHFGCFFLPEDIAAGLPEKLLKTAASASRMEREGWLVRKDMTRYWAMTVI
TVVHDNNGKLLGYAEIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNQLLAFNQCLVEGRNTLLPE
GSQLLSSKGERQEIRCSASPIRDRDNVLTGAVIVFQDVTRARHAQRELQYQANHDMLTGL
INRRRLEERLTQAISQLGDNDQHILCYVDLDYFKDVNDTAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCQSKPATDILESVVADIAAIQFHWHGQSYTFTASLGAVPL
TRQTENAAQSMRQADIACYAAKHAGRNRLSLSL
>A0A1C7FGT4|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTLYKQLVAGMIAVFILLMVSVFLIEFNTTRNNLEQQQRSEVNNTINTVGLALAPYLQEK
DPVAVESVINALFDGSSYSVVRLIFLDSGEEIVRTYPVQPSNVPDWFIKLGLFDKIHDSR
VVTSGWMQLAEVEIVSHPGDAYAQLWKAFEDLVIVFCIVLLIGLLAISFILQRALKPLRM
IVEKMEQVARNHFGEPLPRPATVDLISVVDGINSMSAQLELSFKAQAKEAQQLRQRAYID
PVSNLGNRAYYMSQLNSWLGEGGYGGVALLEARFIKELYDEKGYEVGDNMVRELAEHLKV
SLTTNGIVIARISSDEFGFIIPNIDDDELKLLAQSIVTYVQNLNADPTGMAQAKASLGVV
HNTTSCSASEILTMLDNSLAQASSNPELSFGYTTSDDSRTLMGKQQWKLLVEEAISNDWF
SFRMQPANSSSGQTYHYEVFSAIEHDDKRYSAPQYLFALEQLNVSHILDQYVISAMLDKI
RHDNLTSPVAINIAQGSISQPSFIRWVSQKLNKNKDIAQLIHFEVPEDCFVTSPHHCALF
CNAVRSAGADFGVDNYGRNFQSLDYINEFRPAYVKLDYLYTHHLEDEKQKFTLTSISRTA
NNLGIITIASRVETQTQLDFLSEHFIEVFQGFIVDK
>A0A381I7H5|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNFRLPKKRLPKKIIFICIILISIILFIKYDQNGLKEREIINKGKYMSESLVADKEYDEA
KKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVIDSLEKMRESDVKLSDECRF
NIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKARLDVDLASIFLKIGGYETGE
KLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEEGEYDKAIEISSRIKDYKKFVNTDNY
NDFDIMASIMQSNAYVGKNNIQKAKTFLEKADYLIKSDRTVYILDKDMYYYMAMGNLEYK
SENYNSAIDNYKKSLEISTKRKLTQEKIKNLNKILNIYEKQGNIESLNEYQKMLINEYKE
NKSIRDSETSFYIIDKVSNESKLFEKTKKEIKYYKILFTVILIAILGSTFLYNRLKYFKA
QNLHDGLTNVYNRKSFDIMYEKYREKDDNFALVMIDIDNFKLINDNYGHKFGDTVIKGIT
NTICVMLEQDDKVFRYGGEEFSVLIRNKSGEEVADIIDSIRVAIANKKWNDDVTVTISAG
VAHISDSKDVLEEADKNLYKAKQLGRNKVVYK
>A0A8F5ID81|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MTPSAPRQPRRRSLHAQFVRSLLWPLVLAFALAAGTSLWLSYRSSTAQAAEQRILTLQAF
SHSLTQPQWDCDKTTAQGIIDTLARMPQVDGVRLYDACSDTMLHAGQAMAGPPPAGPDHL
ESPVIYHDPQGRDYTVGQLQISYHPLSALDAVMQSLVPQLGIFLTMLAVVLVGAARVFEH
AVGQPLARFRAAILASRPVHTPHTPTPRWHDELGDVTQAYDKLVHELKLLARHDPLTGLA
NRRALEEHLEHALHQGAPGLHVLLLDLDGFKPVNDRYGHAVGDAVLQGVAQRLRAALRQS
DLVARLGGDEFVIVAPDRGAPDALQRLLDKVNEAVRAPLVCDEHVLRVHASMGTAQFPRD
GDTAAALLAHADAAMYAAKQADTPSGQGSA
>A0A8F5F3B8|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MLAPSVQALEDPQGAYTLAQVMQPPLAGRFAAGLGKDEAFNFGITPSAWWFRFTLDNPGD
EALTRVLEVAYPRLSQVTLYRPDADASVQTMETGMQAPFASRPLAWRAFAFPLKLGPQTQ
QTYYLRVQSLTAFIVPLRLWQPTAFARHVAGDSAAQAWYFGMASAMALFNLLIFLWLRER
LFLYYVFFVVSMAFALAAQNGLVKQFLPLEPPWWSNLAATFGYSLAIATGLQFMRRLLDT
ARTLGPWDGALRALVWFFVLSPAVFPFTGQSLIRTAAVVYLLAIVVVAVVLVHGMLRRQR
SAYFYSAAALMLAAGALVNVLRALGLLPTNVFTANAMQIGSALEMVLLALALADRYAQLR
REKLAMQKDLLQAQTQLIEHLRESEQQLERKVLARTEELSRLNQQLAVLSVTDGLTGIAN
RRRFDELLQAEWLRARRSGTALGLAILDVDWFKAYNDRFGHPAGDACLRAIATLLRECVQ
READLVARYGGEEFVMLMPGESAEGVRRSCERLRNRLQAQAMAHPGSPLGQVTLSVGIAS
MVPGTDEGPHQLLRRADVALYQAKKAGRDRVVVFEPHAV
>A0A6N3CBY9|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNFRLPKKRLPKKIIFICIILISIILFIKYDQNGLKEREIINKGKYMSESLVADKEYDEA
KKVVKTSFESIPEKKYNKVYNEVWDMLKTISYVPDGTKIVIDSLEKMRESDVKLSDECRF
NIEKRLASVYIMDNNYSKAVDLTVKSIKLAEKLGNNYEKARLDVDLASIFLKIGSYETGE
KLIKDSFKIDIDEGEKNGMVRLYAIINLAEIYVEEGEYDKAIEISSRIKDYKKFVNTDNY
NDFDIMASIMQSNAYVGKNNIQKAKTFLEKADYLIKSDRTVYILDKDMYYYMAMGNLEYK
SENYNSAIDNYKKSLEISTKRKLTQEKIKNLNKILNIYEKQGNIESLNEYQKMLINEYKE
NKSIRDSETSFYIIDKVSNESKLFEKTKKEIKYYKILFTVILIAILGSTFLYNRLKYFKA
QNLHDGLTNVYNRKSFDIMYEKYREKDDNFALVMIDIDNFKLINDNYGHKFGDTVIKGIT
NTICVMLEQDDKVFRYGGEEFSVLIRNKSGEEVADIIDSIRVAIANKKWNDDVTVTISAG
VAHISDSKDVLEEADKNLYKAKQLGRNKVVYK
>A0A6B9BG34|diguanylate cyclase|EC 2.7.7.65|Mycobacterium avium subsp. avium|TrEMBL
MGRSLPHPSGDRDARPYRLRLRADAGSVFYRTQQARMLRIFLGATTFLYAYGVVFTLFPI
RAGLTLSNPAGGIVAVGLGLGALAWLAARPDKPAPATVTAIVATPIVMAFHRVIIAEFVC
LIAPMFLAMYLRAFYSPRRGAALVAVLAGLSVAALAVAPTPKLSIDYAIFVIAIIGAAES
FGLLTRALVTAACTDPLTGLLNRAGWEIATADLLSRTRSATATVTVVALDIDNFKTLNDT
EGHVAGDEYLVRCAAFWRQVAPAGAVLARFGGDEFAVCIADHHPTSAKADQFVASVRRHT
PDTSVGTASGAGASADIASLYAAADAELYSAKRRRRDPGLRPARG
>H8FMU4|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MFSTEFVTNYIHRYGARLGLAVLAWIGLWALSYVLGYDRHASLWFPPSALDVALFLAFGW
AAIPMVWIGAGAPAILSSLMLDNSIGWNPICLAVVYGAIHVVSYGGFAWVLNRSRLPRDK
IDHVGVGFLWAPLFCGIAAIGGVLNLAAFTNVTLAQALELAPGWWIGDLIAVSTLTLPFL
CIIHRGRFGTPFQAETLNWLVLTTVLFCTSSYLVYLSAGRIPVSLEAYLQLLPLLWATHR
LSPISISILVSWSELLFVVRAMLFGVGEGAFEYQGAMLAIGAITYVGTAIPTLLAERSHF
QRLASTDGLTGLMNRTSFCALAESELARTRRRGGILSVAMIDLDHFKRINDTMGHSIGDQ
ALKKVSDCLSTVVRTGDLVARWGGEEFVVCFPDTALGSAMEISERLGGAITTLSVGNGTV
RAMLSASIGVAEIGDGESLSDAINRADSALYMAKNAGRNRVLSADLPSLSTVVA
>A0A0A0FEP3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli G3/10|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A859RAA8|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRVVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A379T896|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MRQKNLGLTAATIAHSLEAALVFSDNAAAAETLAIPGRQGQFSAAEARDKNGRIIASWRY
DAQAADDKLIGLISHWLFPLPVSQPIWHNGRTIGEVRLVVRDSLISHFIWLSLAVLTGCI
LLASGIALLLTRYLHNGVVDALQNITEVVHDVRTNRNFSRRVPDQRIEEFHLFAQDFNSL
LDEMEEWQLRLKAKKRTVTATALHDPLTGLANRAAFRSCINTLMKDNSACSSSALLFLGW
R
>A0A8F7N9K7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKIVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSDATQEWEKK
>A0A1V6AID3|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MVKSVFELALYIELNLFAFSILLVLLLFTRSKTNRLLFDQKLFITLIVSNAILLIFDTLM
VVFDGMGGQGYRILLYISTFVYYIFNTLISMFWYMYIHYYIYRNKPALMKQLSYISIPFF
IVCILTVLSLFGNYAFYIDSNNIYHRGRYFILITILSYLYIVFSYILLFIKRRSMKRKEF
LTLLLFAIPAIIGGVIQVIIYGITLLWICTTLSLMIIYINIQNTQLYKDYLTDLYNRRQL
DNYMRAKINNSNTRRIVGYMIDIDSFKKINDVYGHDIGDLALKITAQVLRDTFSQNDFIA
RYGGDEFVVITDINDGEDPYEYIDKINYNLTSLNSKKDLAFKIGLSIGCSIQVPGETLTD
FFRRMDKMMYINKAKTR
>A0A5P9IMV4|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MPSHDVLPDQPPADAPWLLELTEQLPGVIFQLHRSPGGHLHFPYLAGSGVELLGRDRRDL
AKNAMPALERLAEPDYPRLMAIIERSARGGTPIATTFRLRLDGERTHWIAVRAQPREVDS
GILWVGLMIDISEQRLEEDRLRRLSDTDDLTGLANRRKLMTRLDEELSLSNRHGLPLSLI
MLDIDHFKSINDTWGHLQGDQVLRELACLCRNVLREEDLMARLGGEEFAVLLPLTPESHA
RQLAERLRQRIAEHDFGVEGGQVTVSIGVAEHRVGDTREYFLQRVDDSLYAAKHGGRNRV
MAGA
>A0A7H4MXX2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MMAVLFITSIILYRIRHITGHSRKIHGAVLSSCFIFITATLILSWVHSSNSPLLSIEFID
NLTYTFTPLWHNRIGWLLIIIWSLTLILLIGLTRLRNIFWYSGAFFCTAYIFTLLVLLST
VSGNAHSWNQARLFETLSTLFLILILLGDVFILYRESNERYVRSYQNSIRDPLTRLYNRS
YFYDTLTQRLSKASASQPLSVIVCDLDRFKRINDTYGHVQGDKVIQFAASVLQNNVRQDD
AAARIGGEEFAVLLVNIAANEALAIAERIRLSVSEKQEGLPERMTISMGVFTTQDAHVSA
EECVKRADTAMYEAKNSGRNRVVVWRE
>A0A6S6WL65|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MQLLMAGFCVFFLSTGAAYANDPSTAMPAVNPELEQRLDDMLTANMSEAEMGVQLQSILA
TLPADTPVMTQVRIKSYLVMSHAYEGRIDQAYELLEKVAVQAQQSRLPDAITEVAATRIF
LKTQEGKLTEAYTLINTAVVPAQQATLPRVLYFAHNLIASVYTQKNQTERALEHLIYASD
AVKQTSSERTPIRRIYLKLRIANIYTQQTQYQQALEQLSEAEDLVATHNLESTFSPEIQF
QRAYIATDMGELNQAFEIYRDLEAEIKDQPQWASMESTVLNNLGDLAIRTERFESGIATL
QQALKLAQEHNNVISEQMIRFNLGFIQVHLGNYERGLAAMQNVVETARGEWIDREFEPLL
GEYAQALSMAGQHAAANQALIEQRELRSSIFNTELQKNVTELQNLYDSKDKAQQIELLEQ
QNDLKEQTLENERQHRLILALGVVVAVLFSIIGFFLYRSARRSNLALQDANARLADQSVR
DPLTGLLNRRAMQQELKRQEKVGTPQSDAMILLDIDYFKRINDKLGHAAGDDVICEVAKR
LLTVCRDNDKVIRWGGEEFLIYLSNTEQKALPRFVLRLLNSIAGTPITTKSAGDVVVTAT
AGFISYPFTDVEQQKVDWEASVQLVDQALYAGKVHGRNQAWGITQLNVPYTQAKDVLERD
FAQAIEQGAITAITLHGPKASQ
>A0A5Y3AVU4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAIAPPDPPSDHQRSGLRFARRIRLPRALGLAGMFLPIAAVLV
SQPVSGGWWLLLVGWAFVWPHLAWQLAAKALDPLSREIYNLKADAMLSGMWIGLMGINML
PAAALFMMMCMNLMGAGGLRLFVAGMTLLLTSCLVTLQLTGLPVAVRSSSLEVTLSLPVM
VLYPLLFAWVSYQTAMKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHCRRHHQE
ATLLIIDIDHFKRINDTWGHDVGDDAILALTRQLQITLRGSDIIGRFGGDEFAVIMRGTP
AESAITAMSRVHERLNTLRLSGAPQVILRISVGVAPLTSQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6S6WP95|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MDIITIIVLTGLTNLTFALYSWQQVSNPESHAACKPFAQAQLIKAVSYFIFAASLYHALA
DMRLIANLLIFIGCWAEARAYIQLAGTKLRGRFWAIGIVTTCAVFTWMHYTSGDNLNNIM
IVTSSVLLLLPIGTSAYALYQLYRQHPGSAFARVLLTVNSMMLLFCIVRAPVAATNPDFY
ITQRLFMNQAFMFATFIFALGNGIGFIGFLKERSDQKLRQRADVDYLTAIYNRQCFEKLT
KEKLKSGASFSLYFLDIDKFKSVNDRFGHAAGDQALRCFGKLLRNKQEKHHGIVGRLGGE
EFGLLLPQSTASSHQQILQTLRDNFAAETQTLIGEPLTFSLGYCTSNNAASLHELMHKAD
ILLYAAKAELAK
>A0A2T7AXQ2|diguanylate cyclase|EC 2.7.7.65|Cronobacter muytjensii|TrEMBL
MPDKILISRWRTKNPIRVVNLCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDTIATSM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPETDTTMASFQAHRHSAAWVLPAARDHALVIK
GVSDEFVSESTLLKRDDALLHNELNATLALGHMLSIADSRNERPEMRTYYVSRAGFYLTS
LPFYGHGRIPEQYYEQVSSRWFLGHALRLNPARGVRWLHSRDPSMPSGQRVTASIPLDDD
GRWFGVLAMDFPISAMRDFLKNALDNDEAGGEIMLFDRQLSLISTTSSGMDDTLRFSPQE
KATLARQMESGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARLAAKACEAQ
HQPFSVIQLDLDHFKSINDRFGHQAGDKVLTWAAGMLSRALRAEDIAGRVGGEEFCIILP
GTPPEGARMVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A8F4GCM0|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. PL-2018|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDLYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A1V5HDM5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA179|TrEMBL
MTEGLQHLFPHLLPPLASLLISASLIFLAARFADVKREFRLLAVCCVAVFLGNLSHLCLA
LFPGSWTAAFMFETARPVSLLILPVVIHIVHGYLDIRGREAVHWIAYALAFLMIGVLWAG
GSLASRVGLWALVPGAAVSAYVLFCFFPPAAHDKADREDGPVRWIMASGAFLFPLLPGLG
LIVSKAWPVMGFSFVPLILMSSGLAAHPGTKSGCPPSMQSLIRMFIISFILFPIICDLLF
LFHAVDRLQAGDFMSPKFHHIVITVASLLVAGACALLSARKIHERTEALLYMAACLLVCV
LNFRDLITTGLPGHLSRQIILINDIFLVNLIGICGHMVLAASRKWDAKKAAIFYLAGILL
IPLLLYESYLGEGLLSHGLLAQNSLGHLLFIAGLFAGLSWCAHMLLCARKDERNPDRRAG
AAFLATGFILALVILAGSMVTSVGLSSYPFYNLASIPLVFVGYGIFFHDIKRMGIHARRQ
VVSQGLRLLIAFLYAVFGLGIAVVLKDCPPSRIWSGIVPYGIPPMLSFVSAGFLSLFVLG
LERNRPESQLFSLVSFCYAVLNLDIFLQGIVTDSGIALFISRIDHFFLALLSLGVNAHLI
YLVIGKKDNWWVVYGAYIAGLLMAPWTQTDYYFNGTHSYFFGFFAKKAFLYDIMSALWAA
GISYGIYLLVRAYRDPQTRQRTRVRHVLTAFIIIAALSITNNPAIYGFEVYPLGTFVFVA
LFFLAYGLFKFNLKMALQYVRIILFWSGLMLAMAAAGLIPFLFQPQEDAISRTVAGILLV
TILFLPVKQGWNAVLNLFMAKPADTLKDSYYRLTDSLTRIHHRDTIHQMLCSWFFDNLQS
ACFVSLFSLPDLSGKRVFFGWKTWNAHHEGGLFDDAPPRCTGTRTLHIRADHPLMTVCRH
EQTLCSQESLLRVNPSLSAFDGSEQLIKDSEIVIPVMSKDELLCIMLLGGKTDGSSYSYA
EYDILQNISLILGPLIENAMLMEGLEEKVELRTKELNHALNESVQKEREIRENSEIIGRQ
NQIFRTLLETSTRIHHIDNLYELFSFILSQLRTLFADFRGGIILEDRRRGILEATSFIGI
TEDEQKVILGKRNRVMASDFGDILNKALSCAGMPVSEDDVWTVFPMESRGNRVIGYMIIR
GQRIDQLTKEIFTVFLGQLSAVTQNKLLMTQLERMASTDGLTGLYNRAFLNQELQKVIQH
ARQFRNIHFSIMMVDVNGLKKINDTYGHEKGDEAIVRTGALLKSLCRQTDIVSRLGGDEF
AILMPSTNLSQAEILYKRILQASSSLEITVSKQGEDPSCIPVHMSVGLAGSDETPPEMVM
KKADAMMYAAKEQYYACREMARS
>A0A8F8CLI4|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MNRKFKEIDTTIRELNHSTDAHFKWLVNIIRFVARRDVLLSDLTCDDAHNFCDFGYWLNT
QLQDDKEDGNYLLDINTKHIHVHKMCRQLIKTIEDGEHSNAPFDDFETALLAFSASVSRY
KGHLLQLRTSYDALTGLPLRRVLDESFDSMNDELGDAGLYLLLLDVDHFKKINDNYGHLT
GDAVLRSLALNLENNIRRAESVYRYGGEEFIILLQAGSDREATEAAERIRRVIAASETVA
GDHRVKITFSSGLTRVNRGEALREVMERADVALYKGKQSGRNCTILINKNLDCINVSH
>A0A8A8DA18|diguanylate cyclase|EC 2.7.7.65|Burkholderia seminalis|TrEMBL
MTAAAPSLSDLVIERVGFGLFVLDRSMTVLMWNRFMQDHSGIAAADVIGRNLFDCFPDLP
RAWLSRKLESVFQLGSFAFSSWEQRPYLFRFEHDRPITGGVDYMQQDCTFMPLTRGRDVE
AVCVTISDVTHVSVMQREREEAVAKLREHANRDGLTGIANRRFFEARLGDEFARWQRYGG
DLSVLLFDLDHFKTINDRFGHAAGDAVLRETARRVASIVRGQDTFGRFGGEEFALLLPCT
NLDEAMRVADKVRAAIGSMPVDAEGVSVPVTASVGGACARNGAPTSDVLVSEADAALYRA
KRLGRDRSVAYA
>A0A1V5GWN5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA179|TrEMBL
MALASYVMWMFIIFYCYYQGWFRISLAGTILIFAMILLMNLCIYLVFRTGLNKKFKDPSL
TMLQMILATFWSMVVAYYTDEVRGILLLLYLVVFIFGVFRLRLRHFLILSLYALTGYGYV
IMLLLANHPDKINFQAEALYWVVLATVLSWFAAIGSYINHIRKKLAVANIELSRANERIE
QYAIHDELTGVYNRRQLLRIIHREKSLADRGEQSFSLCIFDLDDFKRVNDTYGHLAGDMV
LRNLIRTIRENVREQDYVARYGGEEFVVILAYPDLKEALVCAERIKDLASELSYPGLPED
FRITISMGITRYVPVESIDALISRADTALYQAKTSGKNKIVVMESRCSGSSALQAL
>A0A2N7RUF6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MALIGVLATYAMASSLLYALGMEFVVCVTGVLLGIAISSMARNLRYLNVGGLVTTIFSSI
AFRMLLSASGLGDYWVFPLGVLMTLSISAIASDPLTYLILILVAWLLLGLGGFEQALLAS
GDWSLLYAAAAVVTGLLFSSCFFRLRYSNHVATARLEDMAYRDYLTGIPNRRCFLDALHA
VMNDGKPPHGYLLMADVDDFKKINDELGHEAGDIVLRELGQIIAAAAGTFPHGRIGGEEF
AMLIDGDLACVARVAEQLLEAVRRLAVVQRGVTISVGIARVQGPVLADSFRHADEALYEA
KLSGKDCVVFHGGASGQGQASAGREMHQKSGG
>A0A2N7RDK3|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MDIKTLVLALALGNLSLCAALFFFEYERKKSLSMSTWAVAKQCQAVAWCLLYFRGVLPDF
LSILLGNSLLFAGMALDAGALWQAAGRGNWRRTVLPALGVSIALFAGCYLFDVAPLLRSA
GGSLIVAGFFLAGVAALCLKWREASMLRRFLVVSMGILSLLIAARGMLAATVPGFDAELM
QLAGFGALYLMMLTNAFGYLLLSREKLGGELARLEVVDTATGVPNRRGFYQALAPWMALA
RRPGLPTALVVLNIDHFKRVNDSYGHPVGDAVLKTIVDTCRQQLRDSDLMGRLGGAEFAI
QLPRTNLDDALMVAERIRAAVAALPVKTERAVLQLTASLGVTTIRAEDSTVSLFKRADEA
LQAAKQAGRNRVVEAQPASTLDV
>H6LK78|diguanylate cyclase|EC 2.7.7.65|Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)|TrEMBL
MIAEKINKRNKRIILVLMSLFVFAVVLLANVNKGEDLSIVQKNMFVFLNNWTISDGNDVI
KATQLPVEIDVSPGTDYQATTVLPDVDSQMNYLLLRSSMQDMTVYLDDVEVHRYEEPQKE
ALGIKKPVASTWMMFKLPPDFQGKTLKIVIKSDVAIFSGTINQVRLGESAALIEGIFKHA
LSGFLVFLFLFVIGLVLSLFALFTKSTKDNRFLYLGLLAIATSIWILSEARIMQFFTGNR
YIIGSISYLMVPLMGIFFSLYFKETILSNDRYKRWVQVVAVIYLLGLMTTMLLQIEGISP
FIESMKITFGVIFLNIMIFLVIIILEIKKQKNQNAKKFLKYLSVLCISILFEGIVFFNGY
FDYTSFFLRIGILAFFGLLLLDSYHYVKKGFESQRERDIFEKLAYKDFLTGANNRAAFER
DLDNLMNKTERSFILALLDLNELKYINDHYGHGSGDEAIKNLYTIMNEAFINIGRCYRIG
GDEFAILIDNTDDDLVNSSVQQVRNQLKREESRHEYPLDVAIGMELYDQKIWSNKTKFYH
HVDQKMYEDKMKRKQMRKTKKTIETS
>A0A1D8G2F0|diguanylate cyclase|EC 2.7.7.65|Streptomyces rubrolavendulae|TrEMBL
METESEPYVRLATLRQLHQVVANLNTARSLADTLQTVADGVLTGLGYQLSCVNLVRADGD
LVVAAFAGDPAAEALITGRVGSRTSWDRRLRMGEAWGDLRFIPHTEGWVLVDDDVPQWHT
DGPEPRFEDEWHPLDRLYAPMYTSGGQRELLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
ANDALCRLLGRPAAVMRRYSFADLVHPEDVGTLLRTSPEGGRAELRLARRDGTYIWVSLR
NSVVADTADGPRFLLTHIEDIEERKRHELQLAHRASHDALTGLPNSAELRARLSARLCSR
PDGRVRATAADAAGLAPAYGNGAAYESGAPYESGAAYEDGAAYGGAYEGAYERTYEGAYG
PGATGAYEYEHAYRADGFDFGPSGGAGAGAYDGHVHAVAPVGEIDDGTKGLAVLFCDLDG
FKSINDRFGHHTGDAVLIEVARRLTAGVRDGDTVARLGGDEFVVLADGLGAADAADLAVR
LRNGIIPPIRVDGRAVRVGASFGIGWAECGMSVEEVLNSADQRMYMEKRSRAKVQRRAG
>A0A011MW58|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MSASLQRLPLVDLRADDAEIEHYAALLDSLSVALIAFAADRTPHQHNACAEELLGDGTPE
WIDENGRPLRDAERPELQVHATLRPVHQRAVGIRTQATAAVIWCRASAFPVFAADGSLRR
ILLLLAEGPQHGRIAGDRHHLPAHDPHSEVFTQRHIDILLDEESRRAQRYGTPFAVALIA
IDDFATRCQAEGEERVLARAAHLLCRSLREFDMIGRHGADRFLIILPNVRVNEAMVGLER
LRETIEAGSTQGGNAGMTISGGVSEYSGEDQPALIKRLESLLASARDSGCNRLCVDLDLF
>A0A4U6LPA7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
MIRRTQEIDAILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDISGDDSHVVCQFGQWLKD
HPQHDDDECSYVSKINSTHEKMHLLGKELLLAIVEERSHSWHFDSFQDALLAFTSAVMDY
KIYLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDMVLRSLASNLLSWTRYDEVAYRYGGEEFIVIIRTKTDEQACQAGLRLCHLIGQKKIPY
PEGEIGITVTAGITRVQQGETLDNGLGRADRAMYEGKQTGRNRCIFMNEKEKITLVGIND
QPTLLVRA
>A0A127MQ13|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MSQPFPQRLRQQFRLARSLARPVATENLRRLVWLALLAVPFGLVHILVFWLNLQGSLPEF
DGWRQHIILTHAVVAALLLGLGLLAWQARQRPQAPPPWYCELLALLGAGVLLGFGLVITC
FDQEVTSSITPFLMGAVATALILLLRPVFATLLYVVLFIAFELAMEMAQPDPQLRLSNQM
GGLTICGIGLLLSQILWFGHLRNLRQRQHLRRQRKELEEKNLQLEYLAGHDPLTGLFNRR
QFDQLVKQELARCDRQPMPVSLLMIDLDHFKFINDRYGHPLGDEVIRHTATLLRKHTRSS
DSVARLGGEEFLLLLPDTAAPQARVIAEKLRKLLEDTPLPMKDGLLYLTASFGIAGLASG
VSSTYERLYSTADQALYRAKASGRNRVEVMDASPHGTLE
>Q18BU4|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLGMTNIEIAKKLPDNIAK
FFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKTYIITMANDITK
LYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYEGHNVGDK
ILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQLEALRENFLKVFSKYKY
LSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKFDKNDY
>A0A2X1GC38|diguanylate cyclase|EC 2.7.7.65|Burkholderia cepacia|TrEMBL
MRVRMFITETGDAPASARGSANLQPALPPVPELATVCRVARAHFGAAGAFIAHADADAPR
MLAVDGALPDPLFADGLPPRGEPDPAADARFVPDDTNANANANGQRDGGPPRAPGIVAAC
ELAAPDGATLGMLCIVDDAQRSLDATQRTLLRDLATLAASALCRATEAAALRERLGIVEE
HSTLTTLALTESGTGVWDRNVETGEIHYSPAWKALLGYAPHELGTRIEDAYERLHPDDVD
DVKAAMLAHFERRTDRYAVEHRIRCKDGTYKWICSRGKVITRDAYGRALRMVGTTTDITA
LRELATRLRDSAALVTDLTDQVPGLVFQLRQTADGHRFFTYASAGVSDIYELTPEQVAHS
AEAVETRIHPADLVAYRLSLHESSVRLTPWRLEYRVLLPGQGLRWREGDARPQRTADGGT
VWHGFITDATDRKRIEAELHRMATTDHLTQLSNRHAFMRQSEAALRNVRTTGLAAAVLML
DLDHFKALNDRWGHPVGDRALRHFARLLLAETGPDGIVGRVGGEEFAVVLPKADLDTALA
FAQRVQQRAIAARLMHEDQQVTLTVSIGIDAMRASDFGAYQPLSRADKALYLAKERGRNR
IEVYRA
>A0A8J7V4J9|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MTSESNILPRFLQLQKGLFASLKLKEVLDSSITLFAEMAGGAKVAVFLCDNESTCFKLMA
AKGYSDGSLDQLKVVPFALDSLLKQVHQKRGPIACPDAASAPDFSATVMRREASQGQIAL
PLVSANLLVGAVLLEVNNAQLLTFVDFLKEVSDLVATAISNSILFGRSEYERERLSTLYK
TSCALNSSALEMGQVLKIAADTALVLGNTPTCAILLLDQDQSSFQLAAFKGLDATSLSEF
EMSYSKSIAGSCLRSNQTEMYGDGQREPFGMPRSINGRPFATVLAIPLRHAERKIGVLEV
FSTESRAFHREHIDLLESLSSQVSTALNIALSHESSATSSVQDAHTGLANRVHFESLLVK
ELERSSRHSHELSLLLVDIDHLSQINEMLGQMKGDDAIKHVANTIRAALRDIDVPSRYGG
EEFAIMLPETARANATEVAERLRATLRQTPAPGIGLITVSIGVASFPGNADNANGLIHDA
EQALNVAKYEGRDRVRTALTGSFAEGGDLSWEDLASKAKMTVISERQARLQSRLTATPEY
ATWLAKPGSLVGKKKGG
>A0A8J7V736|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MAKEIVIVDSDQHFIKLVASVLEGRGHKIKSATTLKEAEPLLLDVCDLVILSSPLNDSTE
LPWLLERRRSGFTAKLILVGAGKQHVDSIKSKITADHAISLVVHKPLIPYIFGAQVDRLF
DDDRSEAAAQKMKDFETMFLALVSKYARVLPNRINELAEAIEKAKQDPTNIELTEEVRNI
AHKIKGTGGSLGFRRVSELMGFIEDTAINLQQRPKEEQLIAWADVDRKLLEVKEAGDSEC
QEINEAVASSGHKPQPAPHNPAMTRILVVDDDRGFLDIVSELGKQRLVDIVQASGIKEAL
EQAVVYPLDAALINVVPENPELCFSLARQLRELPGYENLPLAFVSGQALVKDRVEAAHAG
ASLYLDKPLQSDALEKAVQHLVNIRQGGRPRILICDDDEFFCNTVALVLRNEGMIVRILN
DPAKILDTMQEYPPELLLLDVMMPGVTGFEVCRMLRQIPRWQDLPIIFLTGQTGVEARLE
AFRSGGDDYLPKPVVNEELLTRVKVRLDRSRMLRDRSDKDTTTGLLLRRAFSEQLSAILA
EAQRLKSTFTVCLLDVDHFKKVNDTYGHLAGDKVLAGLGQLLSRRFRVDDLRGRWGGEEF
MLAFKRETKATMHLAVQRVLDEFRSITFSGDKGEEFCNSFSGGIAEYPIDGESVFELVKI
ADARLYQAKKRGRNQIVLDNDIFEEVKSESSEASVGH
>A0A7S8FBG7|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira kreftii|TrEMBL
MNISNSHHNRRILVVDDNLSIHNDFRRIFHRESGPKDLAEAHVALFGESHSMDSHELFEV
DCADQGRTALALVEAACKVGRAYAVAFVDMRMPPGWDGVETIEHLWKVDSTLQVVVCLAY
SDQPWEEIRDRIGRTDQLSILQKPFNSIEVLQRATALCREWDLTNKAVGRLDKLSHLVDE
RTVELQHANRQLTETNGALMRTVADLEAAQAEILRQNGELERLASRDPLTGCLNRRAFYA
LFEKAFADSRDQGSELCCLMVDIDHFKRVNDQFGHAVGDQAIQAVAHCLHAGLRLADTVG
RYGGEEFSLMFPRTTLAEASELAERLRIRIGAEAGTRVRVADGLVLTVSIGASAIMFGAQ
TPLELIDQADKALYAAKEGGRNCVMAMDLLVPGLSPAEQLELQVRRITPRASSSTTR
>A0A8G0V5D8|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MVRWSLKSRVVASTVVVVLLLAVLLILVARHYVFANLEDSLQAQQDAQVRLVAEQLDDKF
EVRTVILRRLAEHLAPLLDRGPAELKRVAKQAAPAPELFDGVFLAWPDGKRSFDTRTIDP
DPDVSHRPYFRDALRGASVVISEPVMSKVTGGPGVAMAVPVRSIDGRIRAVLVGSLDLRR
EDFLLALSRSRIGTTGTYCLVSSGRSRRYVVHVDPEKVLQPASSEDESCGTDTARSIWEF
AWPTRPIIARHRLETAGWELVAALPAREAFSPITRARLRILTAVGAALAISALLMWRVAR
RLLAPLESLERVVQESATDFSKCALLPTSRQDEIGSLAKTFSRVMGQLAERTSFLLAARK
LAEEREARIHAIANHIPDLVAYLDLDERYVFVNHAYEQRFGVSADEIIGLTPLHLWGAAV
YAKVIGPPLRLALSGELVKFEAEHLYENHPVCFDVTFQPAWSATADKVVGVHVFARDITA
ERQKMRSLEQTTMSDYFTGLLNRKGFDRRLESAMVQSEEGSKIMALLLVDIDNFKLVNDT
YGHPVGDKLLNVVATRLKSCAGETCAVARVGGDEFAVILEDVLTSDEVLRVAQAILSVTC
ETFILNGHQIACSTSVGAALKKPRDNNTRNELLLKADTALYSAKRSGKARFIVFGESETI
ASDSNDHPRSD
>A0A142YMN5|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL62|TrEMBL
MTVHRGAGRDDVASTPRQAFGIVPGEPAVVLVVDRDPARRSRAGVVIANQLGRRVRYACG
PEEATAVVRGEDVAAVLAGLQTDDGVGLELVRSLRRSRPEIPVVVIAGDEGDEKSEAEVA
EALRMGATDYVARDRLEAELGPTLDRLRRLTSPVPPRGCEGLVRQESRFVVADDPEALAV
AIAAVREQFEVVGGWDPADSLRMAIALEEALRAVVGPDRRAALTVVHEPDASRFTLRKDG
EGAAPPPAAGPLAAEPSRRFSTRALRLMRSFMDEVRFDRDGDGVTLVKRLASRQGRPAGE
ATDHDSARRLIEAFPDAAYMVDATGRILYWNEAAVRFTGYSREEMIRPFATVERIAFTDS
LGVPLSREKRPAACCLREGRSVELHLFFHHRDHRQLWVEVRGSLVRDNSGGVAGCLVVLR
DATSSIVVEQALRQARREAESDPLTGLANRRTFDRLLDLHLRMQAREGRPFCLIMADIDH
FKSINDGWGHAVGDRALTAFARMLQNQSRAEDVVVRFGGEEFVILLPDHSLDVAARIAER
LRAATPSSAPPELGDRRLTASFGVAQALAGESASELIRRADAALYRAKDRGRDRVELDQV
GGAGEEPGAAGRG
>A0A1C5NYP7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKQMIRKRLCIVILTAMLISLFVNYFQLIHNAQSGMYRNSQNKFWQIGQILNQNEKETQK
AKESLMEQCFMSAEAISYMIQGKPDIVENQQEIQRIAGMLQVDEVHLFDTEGNLYAGSEP
RYYGLNFNSGEQMRFFLPMLKDYDLRLCQEITPNTAEQKLMQYAAVWSRDHKGIVQVGLE
PTTVLEAMKKTELSYIFSLVTSEKDETIYAIDPDSGLILGSTDDGLVNRQIQDIGIEPGH
LGVRGRGIRLMINQEDSYGVFETSGSVILGITKSTAALYGELNRSTLLLAFYLTCISLIM
IVCISAYIDRYIVDGISSIHEKLERITRGNLDTRVEVDSTPEFGELSFQINQMVESLLDT
TNKISQILEMSKAPLGVYEYNCDMRRVMATNRLAEILMIGRSEAETLFSDYTLFEAALEQ
VKKHPVEGENGVYRMEGEEVRYIRLETFARGHSTLGMIMDVTDDIREKKRIEQERDVDLL
TGLYSRRAFYRQTEALLSGSEPLGHGLMLMADADNLKQVNDQYGHQNGDRYLAAIGRILI
SCAWEKCVTARLSGDEFAMFLYGAGSREELMVPVRKMMRDMEEAGVELGTKERIPVHFSA
GYVFYPEDGCDTAVLLKQADEAMYDAKKTFKAASAHGGGEPVIYS
>A0A1C5WHP8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLNREIQSDRKNKNIIGMMQSCLILILVVLIIMIMVQITRLQGTARVINYAGLVRGDTQR
MVKLEITGSRSDELIKYLDDILSGLRYQDGHYDLVKLHDKEYQDKLQVQSDYWEKLRTEI
EAVRSKGYQNTDIVNMSEIYFHMADETVFAAENYSEKIAVKIRTIELLSALDMLCLVILV
IMQTLTAMKMAMKNKLLEQRAYTDAHTGLPNKGACEALLRDQDTIVEPTACIMFDLNNLK
TTNDTMGHSAGDRLIMDFARLLRSVIPDKHFVGRYGGDEFMAVIYHTSKTEIEELLQSLS
REKDRWNNNENQIPIDYACGWAISTDEGTCTLQMLLDKADSDMYENKQLCKKRNLGSHQE
TQK
>A0A1C5PHS8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MINQEVQSDKKSKNIIGIVQSCLILILVVLIICMMIQISRLQGTARVINYAGLVRGTTQR
EVKLEITGNQDEELINYLDDILSGLRYQDGHYDLVRLYDKEYQEKLQIQSDYWDKLKIEI
EAVRNVGYENTDIVNMSEIYFKMADETVFAAENYSQRIAERIRTIELLSALDMLCLVILV
IIQTMAAMKMAVKNKLLAQEAYTDAHTGLPNKRACKELLINKEIIKEPTACIMFDLNNLK
TVNDTMGHSAGDQLIMNFARLLRSVIPEKDFVGRYGGDEFMAVIYHTSRTEVEEILKCLC
EEKDRINSNENQMPVDYACGWALSADDRTYTMQMLMDKADSDMYANKQLYKRDNFIDRKE
KSLYNPY
>A0A1C6L7R4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MPGWYVIVELTNKNISDITQQFSAWGGVYGSILVGFTMLYMLTIVLLEKKDKKMYMGLST
TDSLTGILNRRAFQIAVEEELRKKTPGIFIFIDVDNFKIYNDTYGHNNGDFCLKHFAKTM
KSCFPEDSIIGRYGGDEFVVYLKNLTGEMAQTYMEKFQRMISQLTLPTGEAVELSASAGG
AAFPEQGEDVMSLCKSADMALYKVKQNGKADFKMKGM
>A0A1C5NPC5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MVPDYYNIIHMNTNTNNHKTSYSITRGLFFLIICSVIFTVLYYSLPRQNREPAISDYIDF
SEGWTTSDGRPVDFSHISGICTVTKKLPALTHDMALFFFYKSSNVTILIDDRQIYETMQP
EGVFFGKTPGASYVSLPIYREDSGRTLTLVIDNPYGDGSGKINDMYLGRSEDILISRIRD
KAPGFGISFLIAHLGLAFILFYLPLHKKHIIGSEMFYLGLFALNIGIFMLADNRMLQLIL
RNSHIYHTIAELFMMLITIPLFLYLGKMYTEYSPVMVQAACLISVMDFSIRFCLNLTGRK
DFHESLRLTHITFSILIALVIYAIGKGFYQNQKQHLKHNLYHNLGILCLCFGVLLDILLL
WFGSAPETSFFTRIGVLLFLIMEAVQVTLRLMTNYQEGVRMQLLSRLAYRDGLTDLLNRT
SYMEELKRLDASHNFHVLLALYDVNNLKYVNDTYGHQSGDEMIRRVADTLLAHLGSLGKC
YRIGGDEFVFLSTAADSEKEFLKLQRDFEASLGVLKLPDGSEHPITVAMGYSVLTHNMPR
SMDDVVREADVKMYEAKRRMKTENRS
>A0A446CWL2|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MDFFAAGNLLLALAYILQLVEGGPAWSVMSVVNHTLTLAAPIAYWLGAMRFFGRQVRLWR
SLIIFSVAYGIAQCLVQWSAGPTARYAMLAAMASVLFFVMTITVIYGVRTFAKDLYGEMF
FFALLIGGICILNALKFLKIVDGGLDALHMDSRFQMIFYIYMSTLATIVPPSIVWLVLRR
LTDSLRNMAARDPMTDLLNRRGLLDALTQSFNSRNAGPARLLLLDVDHFKRINDTYGHQA
GDEVICQVADILRSTVRRDDLTGRIGGEEFVAVFLEADGDRVIHLAERLRASVESQAIKV
AGSGNVLRCTVTIGISPPFHGAHDLEDALRQADAALYRGKAAGRNRIESAEVFDSVSVED
PKAAIV
>G7G4Z7|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. BSi20495|TrEMBL
MFEIDQWAFSGIDGQISLHKWQKTIDLITGLFSAPSGYIVQATSKGYRVVIRNNEGGSNF
ETNPILPPQTPLFCKYVAENNNTLYVNNACNNDAWNTLPEVVEDGVESYLGLPIHWPEGE
VFGTLCLKDTKKTTYTNEYFELIEQLRDLIEDDLALIYSYEQMREIAMLDALTNIYNRRA
LSLLAQQKLNLALRLGFDVCCLFIDINDFKKLNDTFGHEVGDKALIILADTLKTHLRDAD
IVGRIGGDEFVVVMQVSDKSKIGYIMDKISTEYSKALLKEDVCDLSLSIGYSFTDKQRQS
FEKLLNDADQAMYKNKQAYKLAKKAQL
>A0A245ZKK2|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MPGWVKQCLMWLVACAVAPWALAPSASADIGVVGSPVSVCIAPVRAGDTLAAMLRARDRF
DCTSDQKSFGSGDYWARSEPLSAQGPVSLRMASLWQQQVTLWTVYADGVVTKRSFDGKAL
ARTIQFGAIVEMPLATRAAPVSRLLWRIDGAANVRGVLVGARLASPQESATSNLAMAASY
GGFAGLCLAMFVYNLALWSAQRHSFQIVYCAMLLSLGGYAFSSSGALAWVWPDLPNNYRL
RINYLTLAASGACAIAFARTFFEPRVFSGWLNHLTNLVIAMVLGSAILLALATGWEKVLL
DRLYAFSFLLLTLTSIPVLWQAWRRRSDYLWLFACAWALPILLAAIRTAGNFGLLSWSFL
LDNSTLAAMAAEALLSSLAIAYRTRLLARERDEAREQEHAARWLADHDPLTGLLNRRAFL
REAIGRSGDHQLVLVDMDHFKSVNQALGHDGGDEVLRLVSRVLARVGAQSDALVARLGGE
EFALLAFADAPIAVELVLHAIRAERMPSDRHVTASLGIATGPIYDEAGWQQLYRTADQAL
FAAKAAGRDRARGTGAVALAA
>A0A403A534|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALADVNSFYASCEKVFRPDLRNKSVVVLSNNDGCVIARSAEAKRLGIKMGVPWFQLKT
AQFPEPVITFSSNYELYASMSNRVMSHLEELAPRVEQYSIDEMFLDIRGIDRCIDYEDFG
RQLREHVRSGTGLTIGVGMGPTKTLAKSAQWASKEWKQFKGVLALSPENPRRTAKLLSLQ
PVEEIWGVGNRIAKKLKVMGITTALQLSLTNPTFIRKNFNVVLERTVRELNGESCISLEE
APPPKQQIVCSRSFGQRITTYEEMRQAVCQYAERAAEKLRGERQYCRHISTFIKSSPFAV
NEPYYGNVATEKLITPTRDTRDIIAAAVRSLDKIWLDGHRYAKAGIMLNDFTPSGVAQLN
LFDEVQPRPHSDELMKVVDGINHSGKGKIWFAGRGIAPEWQMKRELLSPAYTTRWADIPA
AKLT
>A0A0S4HSZ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MSLFKPGTRPTLRSVIGRGHLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKAAATEALAMIASTEEVADAQVLDAKGQLLARWQRSESGLFSDLELQIAK
TFLEKPIDLPIVHQGREIGSIHLTGHGGSLMRFLLSGLVGIILCTAISAWVALYLARRQL
RGITGPLRSLAAVAHAARSERAFDRRVPPADIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNANKLNERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVATRVRAQLREEDLVARLGGDEFAVLLSPLHKTEDAERIADKILASMEAPIPL
PGGNPVLTSLSIGIAVFPDHGVTPGTLLHAADAAMYQAKRVSRGAQRTAGSEHPVTHAQT
RS
>A0A7W9WSZ2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia bannensis|TrEMBL
MKPSTHPMAGKGRRFVERTWRLRMVGLALGFFCVASVFLQQQRGAVLWSLLVFHGFIWPH
VARRAAHACVVPYRGERFNLMIDAAMGGFWVVAMRFNLLPCVLILVMLSMDNIAAGGLRL
FLRGVAAHLLGLAIGWLTLGFVVEPETRMATIVACLPFLIVYPIALGWSTYRISRKLAEQ
TRTLEGLSRTDGLTGLLNRRQWEILLADEFERCRATRYASSLLLFDLDHFKVVNDTRGHQ
AGDAVLCAFAMLLREHFRVSDCIGRYGGEEFGIVLPGATLAEARSVAERFVATVREKNKE
AGGQCPCTVSVGVAQCDESMMDHAAWLKLADASLYRAKMTGRDRVVTA
>A0A1V5SLB3|diguanylate cyclase|EC 2.7.7.65|Candidatus Atribacteria bacterium ADurb.Bin276|TrEMBL
MEIDIRTLSLVNSIAAVIQVIALTLQYILVKTYRGIGWWLIGFLMFALGFLFAPLRDISQ
ISQISIFFHNLTLILGIVFLYIGLLRFLNLKENKKIIIFILVSYIFLFTFFLYIQDDITA
RTVIFSSFSALLMFSISFRLLKNLDKSLKTSQLFVVIIFFMQGCFLLFRTFAVITISPVS
DFFTPTLTQSLTFLSYIIIGNLFTFGFIIMVNQRLNIDMKEAKEHFELIFNTSPDAAIIT
RLDNGEIVSVNDGFTNLTGFNHKETLGKSILELNIWKNPADRQKLIDDILKNGFCDNFES
EFLKKDGTQIFGIISAKTINLHGIPHIISVTRDITIRRKVLEALKLSEERYHSLFENMID
GYAYCEMVYTEQNQPVDFIYLEVNKSFERLTGLENVVGKPVSEVIPGAREMNPELIEAYN
RVALSGKSESFEIFFKPLNIWFDISVFSPSIGFFVAVFENITDRKKVEEELQHLASIDGL
TGIYNRRFFIEACENELTRFHRYGKTFTFLMMDIDNFKSINDQYGHLSGDQVLQSFVKTI
ENEIRNVDSLGRMGGEEFGILLIETPVKEGLKTAKRIQNTLQNKKIQLNSDQSITTKVSM
GLTEVNSEDTNFDSIISRADRALYKAKNLGKNRIEVSE
>A0A7Z7MTY7|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MKSTTDKQRFLIALVDYFIHPSLRVDSDMFHRARILIATILIFPVVSLSAFLAVPLINFT
QTSILIAGGLLLPTTGCFIGLLALLHRRGSYMFSAVATVCVLLLLVVGGICVSGGVAHSP
VTPLLVVPPLTAYFFGGVRWGGHVVAAVFLILISMVILHYFGIDFIQTVNTPEQLIITHF
LVSFVNLAAISGMGFIYEFTAAALKRERDLEREKYVRLAKTDPLTGLANRRNFDAMLQER
IDLYGMQAPPRRFALGYLDLDGFKPINDQFGHAVGDEVLRIVSERLRAVLRGSDFVGRHG
GDEFMLMLDVAGGEPEAMEKMANRLLTAIAKPIKTSAGEVGVTGSLGFAMFPLDAYGIEA
LKQYADEAMYEAKKEHNTWRTYNKAIAGKGKK
>A0A0S4I8B2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MAKNNPKILTGTPPPDAAQTLLALMHAQGEVARLSEREQLFSSLLESVNAVLWAFDWETR
QVLYVSPAFERIFGRPVSRVMADFNVWRDSIYPDDLEFAEQSLAQVLSTGSVEHREYRIL
NGDGELRWLSDKCYVSQQPGSDRVTIVGIAEDITDKKRLEGELQRLATTDVLTQSSNRRH
FFECAKQAFDKAREDGTPLTFLLLDIDDFKNINDSYGHQEGDQVLQRIAHSGRTVLRRGD
LFGRIGGEEFAAVFPGCTAKVAEQIAERLQREVQRLSFGQEGQTYSVTVSQGLTGLMEDD
DTLNSLYARADAAMYQAKRQGKNQIVQG
>A0A8F8CVL5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter septicus|TrEMBL
MPYIKTDEAILLERSKRYVHRIFLMRQTGTILCFLSISSVLHYLNYSLFVYILLGINAFI
WPTVAYVYAKSKQDAVKTTNMSLVVDAALGGIWVAVMGISPFPSLIMVAILISDRYAAGG
WVILKPSLMAMLVSCLVMWVLLGFHVNVDFDSRIVWCSLPLATLYIMFLSVLTRNLAVQL
IHKNREFERIALMDPRLHIPNRRLFEQRLSSIFIQTQRNGTHAHLMLLDVDDFKYINDTY
GHEAGDYFLAEISSILRHFIGPEDTPARFGGDELAIIVVDRSNDEILILAENIAACIKNI
RLQSDEHFSASISIGIASVETAQTVSEWFGLADKALYYVKRNGRDGIQIY
>A0A378GIN1|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MHPLKATTPTPTGWWSKLARRVKPERVVNICFVVVLFFSTLLTWRETIVLEDAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMQSALQVPLAFEVLRAAEQQFERQRAQSDWQISL
NNNRTLPLHGVSDAFVEHTNLLSRDNPLLGNEFMATIELGYLLRLSAMTRQHLARFETHM
LYVSRAGFYLSTDATQQDSITEYYYRLATSPWFTQQSQRDNPNRGVKWQTTFSRDKTPAA
QTVTAAVPLDYEQYWFGVLAIQLSVNEMTQFLTQSVEGEEEGEYQLYDRRMNLIASSESD
ASKRTQLSQEVQAQLAHAYEQQNEGSVRQFSRYISWEKLRNFDGVLLRIHSLEEGVRGDF
GSISIALTLLWVLFTTMLIISWIVIRRMVRNMSTLQDSLAWRAWHDMLTRLYNRGALFER
ASKSLAACQKAGESLAVIQLDLDHFKSINDRFGHQAGDRVLIHIGRVILNKIRKEDIAGR
VGGEEFCLVLPDTSLAQATVIAERIRESINSREILISRNQTIRVSASLGVCSSDELAQYD
FQVLQSIADKRLYLAKTSGRNRVCAEDGEDRDK
>A0A2H5X825|diguanylate cyclase|EC 2.7.7.65|bacterium HR16|TrEMBL
MTVARSRSHVDTAGIKTPPALHLASLPRATARAMEQLMDTMLATLHVDAGAIWVEHEQNT
YSLVMRHVAIPEMQALQQAIASCGQQYPMMIQAGGQNYVVSCTGYPLLRIYAAVRVGAVR
PLYRRLMPHFTRLAQTLLQANASPIGMPAEDTSHQAYRVVVENSLRRLCELMQATGCTLL
WFSSWNNSWHRFTVGSVPSWLYQHLWEMPSPGDGLESWARGIEALIRHRGQHCVTDELTV
RDAVKGCVFVWRDKTHGDFASEEVEWLRVTVQMIAASLDVLETQTELLQRVYQDPLTGVF
NRLYFETAYRQILHNAQRHPRPVSLLLMDVDNFKRINDTCGHETGDMVLQMVGQVLQQVR
AGDIPARYGGDEFVVLLPDTDKVGARTLAQRLRSAVRQASEQLGLPFPISLSIGCATVTN
GDPSLLLLADRDMYEQKHAEKANAG
>A0A5E6W933|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTAVMVRPTLRSVIGRGHLILALVAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDRAAATEALSLIASTEEVAQADVFDASGRLLAHWERPETGMLSRVELALAHTL
LEQPISQPILHQGRTIGSIHLTGHGGSLLRFLLSGLAGILICTVLSAWVAXXXXXXXAVA
HAARSERDFDRRVPPARIAELDSLGSDFNALLGEMEAWQSHLQSENETLAHQANHDSLTG
LPNRAFFEGRLIRALRSAAKVNERVAVLFLDSDRFKDINDNFGHAAGDAVLVAVADRVRA
QLRDDDLVARLGGDEFAILLAPLHKVEDAQRIADKIIASMDLPIAVPGNTQVLTSLSIGI
AIYPDHGVTPGTLLNAADAAMYQAKRFSQGGQQTAESEHSTVNTQHRS
>A0A3S4QM87|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGRKGLSMARRLYTSRTLGLALGLVCVSVAMYPLDPAPWVWALMICNGLLWPHLAYQ
WARRSQTPYHAEYRNLLIDAFFGGFWVAAMHFNPLPSATTVSMMAMNNVAIGGPRFLLAG
LAAQIFGMGVGLVVFAPAFIPQTSSTQLYACLPLLMFYPLALGWICFRQAHTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKEGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDIAGRYGGDEFCVILPDLPLFNAAQAMEVLRERFVTLGYDQDPA
LKVSLSIGLAAYEPAHVDATRWLNDADQALYEAKAGGRNRVICNCDTPRHELLDSV
>A0A5E7T1L0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKMGGKGLSLARRLYTSRALGLVLGLLCVSVAMYPLNPAPWVWGLMLFNGLFWPHLAYQ
WARRSTTPYHAEYRNLLVDAFMGGFWVAAMHFNPLPSAITLSMMAMNNVAIGGLRFLLLG
TVVQMLGLGIGWLIFFPLFIPQTSPLQLYASLPLMCFYPLALGWICFRQAHTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEIEFQRCQRQQRGGAIALIDIDHFKSINDTYGHVAGDI
VLRHLSKMLRQNLRATDVAGRYGGDEFCVILPDLPLNSAAVAMEALRDRFATLGYEQNPA
LKVSLSIGLAAFNSTHADATLWLNDADQALYEAKSTGRNRVICSDNERPHRALFDSV
>A0A5E7KH31|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKSGGKGLSLARRLYASRTLGLALGLLCVSAAMYPFDPAPWVWGLMVFNGVFWPHVAYQ
LARRAKVPLHAEHRNNLVDAFIGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
VVAQILGMGVGGLVFTPTFIPSTTPLQMFACMPLLIVYPLTLGWLCFRQATTLGRQNREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQQQGGAIALIDIDHFKIINDTYGHVAGDI
VLRHLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNGAAAAMEALRDRFASLGYEQSPG
LKVSLSIGLAAFDPTHTDATLWLNDADQALYEAKTTGRNRVICRSNGMPYHELLDPV
>A0A5E7G3E7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSLFKRGARPTLRSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKSAATEALALIASTEEVADAQVLDTHGRLLARWQRPETGLVSDLEMQLAK
AFLEKPINMPIVHQGREIGSIVLIGHGGSLMRFLLSGLVGIVLCTAISAWVALYLARRQL
RGIIGPLRSLASVAHAVRSERAFDRRVPAATIAELDNLGSDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLMRALRNANKLDERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVAKRVRAQLREEDLVARLGGDEFAVLLAPLHKTEDAERIADKIIASMEAPILL
PGDHQALTSLSIGIAVYPDHGVTPGTLLNAADEAMYQAKRLARGAQHTAGSEHPVADV
>A0A5E7P9I1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLFSWKARPTLGSVIGRGHLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKAAATEALAIIAATEEVADARVLDAQGQLIAQWQRVETGLFSELEMQITR
ALLEKPVSLPIEHQDREIGRVLLIGHGGSLMRFLLSGLAGIVLCTAISAWVALYLARRQL
RAIIGPLHSLAAVAHAARSERALDRRVPPAQIAELDNLGNDFNALLGELESWQTHLQNEN
ETLAHQATHDSLTGLPNRAFFEGRLIRALRNGKKHDERVAVLFLDSDRFKGINDNFGHAS
GDAVLVAIANRVRAQLREDDLVARLGGDEFAVLLAPLHTVEDAEHIADKILASMDMPITL
PGDSSVVTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRLSRGAQFTAGSERPVDSVHT
RS
>A0A5E7HSI9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLVPGKSVKSGPRADSLHGPNVLETPVQERETMREMAREFEQQLTAVQMASMDSLTLLTN
LHGFQVLAQLWLDACRQLDKPASLLFFDLDYFKRINQLYGRSEGDNALKTFADVLRIAFR
ESDVVGRVGGDEFAVLLTGSSAVDVAGVRARLEEMLDERNATVHRCYDIRFSVAQVEFDP
LCHKTVEGLMEAIEARNQGSTGY
>A0A5E7LHT4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKTGGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLNPAPWVWGLMVVNGVLWPHVAYQ
WARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQILGVGVGLLVFTPAFVAQTSPLQLYACLPLLSLYPLALGWICFQQATTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQQQGGAIALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVLLPDLPLDSAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFDPSHTDATLWLNDADQALYQAKTTGRNRVIYRIDGKPHHELLDPV
>A0A518GSY1|diguanylate cyclase|EC 2.7.7.65|Planctopirus ephydatiae|TrEMBL
MIPVERIWNSAQLPTLPAVAVRLLEIVRDPESEIRDVVETIKLDPAISAKLVKAANASYF
GVRSEVKAMDRAVSILGTTVATSLALSFSLTDESLQTGPKAEYYRNFWVHSVVQAATAEL
IGQKLEPAQRGEYFLTGLLLELGRLAMLKTIPNEYIPVLEEAKLPGTSLPELEEAKLGFT
HVQIAQQMMTLWKLPEGIIHAAAFHHAPLDKVLELRTDPNTRLLGAMAFSAAAADYFCSA
NKGLALHSLREISTHCLGMTEDDLVIFLSSIEERCHQAAELFNVSISHLQSSSDLMIQAN
EQLVQLALREHVASTQASIRQHVAEQEKRELETRNRELQQQALHDPLTGVHNRKFFDEVL
LREVHRCVRAAQPLAVIFIDVDHFKNVNDNFGHQFGDQVLKRVAQIFSETVRVADTLARF
GGEEFVVLVSQPSEKGVERLAERIRENVEKEAFRFGSTPVKITVSVGAAIAIPRRGETGI
GDRLIAVADECLYEAKRNGRNRTILRHVMDERDRQLQQLITQTRFSRWLVQQRLLDVPSI
SRVLLDCQTPHVQCGELAVRMGYLDIAELHSILKHQEVTGDRFCAVAVRLGLMTATETVF
VLATQQEDPRTVMGALVRTGLLSPDAASGALEDYTRMIAPPAKHRVMAFA
>A0A5C5Z819|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MTDSIATSAFTNPVAAPFLSALDAESATSVLPEKRNQLEMLLAGLQDAAPAAEENPAVNK
VDLKFENRLAMVRLGIATSLFYSLRAKHVATAAHSLRVALSCSTWAHRLGLEDAQRDRIE
VAALLHDLGKIGIPDRILRKPGKLTVEEQLTMDCCSRLGCEILHGCTDDSELLDTVLHAN
TWFESRRCEDGPQGDALPLGSRMLSIADAFDAMTTDHVYRNAMSRERAIQELSKGSGTQF
DPELVIDFSRMVEDRPEVLQGIVADRWLKNLQGNSGASLWASTSNDFSEAISPSLRSEAF
FLNQLVGKLKDGIAFTDNEGTITRWNDAMQRITSISADAIGGKVWSDETIRLRERDASRH
ENACVVSECLLNGTCISRPMLLERPGQRPIPVHVQVSPVTGDARTSFGVVVVIRDLSDQA
SLEEKVETLHEQTTRDSLTGIFNRAYFDSRLTAAAEKTSSGGATFSLIICDIDHFKRVND
VHGHPAGDQALIQFASTLENHSRDGDVVARYGGEEFLLICKDCDNATATKRAEVIRGALE
RTPLSSLGGAAVTASFGVTEYQAGDSAETILARADRALLKAKDNGRNRVIQLGAGNCPVQ
HSEPRKRSWFGLFESGDARQISEFDILTPVPVDLAIEKLRGFIADHDAKVIRVNENQVSL
KVNAVCTTGGRRRIDHHITLDAQLTLSEQKKFDQAGTPNRKWQGTKVHAVVRPIRNRDRR
SRALNPCITQLIASLKSYIMGEIIEDSI
>A0A1C6BMF0|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MFTSDTAKYKIIGICTSCVQSDYVRDIVSSISRKGVKEGYKVLLFNTFCDLYHNISYNHG
EASIFDLINYDILDVLIIMPEAIKRDSISNEISKRAHEHGVPVICVDSTMDNCCSVTFNY
SDVFEKIVRHVIEFHGCRRVNFIAGVKGNAFSEERIEAYKKVLAENGIEFEPERLGYGDF
WDMPTKGVLEKFLESSLEFPQAIICANDAMAIAACSILRERGIKVPEDVIVTGFDGIELE
QYNSPRLTTAAVDNDVLGEKIINAIDHMMNGVPLPEKIEVSYTMRISQSCGCKKIDPREV
GDKILELYHRMNNSDGHEQHMFSYLAKSVECHTVEEMAKVMARSGDYYSWVCTNSDFLSN
TRQRERFNNSFTKQMRVFMQTFDNKYKTGEVFDTKDLLPDMEQVLGRHNCLMFSPLHFQD
EVIGYAANSFSPIYFLFQNTRRFINNTNQIMESFKNRQRLERANAELARIHMLDPMTGIY
NRRGFYKNVKKLISKAEKQGVGVWVFSIDMDNLKKINDLYGHNEGDKAIKAVASLMTKCT
AEGGICSRFGGDEFVAVIAETDGADSFYEKVSRSIAEYNRRSKSPYDVSISCGYKAGKPK
TLKEIDDLMKESDREMYTQKRKHHSRRD
>A0A5P9JH04|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MRGPSPLEQEIAGLLANPEFEGHPLKEALSQLWSAHHDLLGRIERIARVSDGYQSIARER
ELSLAARFDKQLRQLEKVARISDRYQMMMQDLNASLREASTLDSLTGIANRRLLTERLRE
ESERAKRYARPLAVVMLDIDRFKVINDEYGHEVGDRVLIEVVRVMESEIREHDLCGRWGG
EEFLILMPECTAATAQPVMRRLGDSIASLGVRVNDDLLGVTASMGIAELHADETYSNTIN
RADLALLRAKRSGRNRCELAD
>A0A5P9JMB9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MRAKLNDSTTDDSEMRYRLAAKATRDAVWDWDLESDHVLWNEALEQAYGYPLAFVDTSGQ
WWLEQIHPADRERIRRSIHAIIDGGGTTWTDEYRFQRLDGTYAEILDRGHVIRTAQGRAV
RMIGAMLDLTRVRAAEAALRQSEERFSAILQTIEAAFAIVQVKFDADDRPVDYRFVEVNP
AFERQTGVDLRGKWVTEFAPELEQFWFECRQDR
>A0A1C6EQX9|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKDRRKNKRKRKVLLTLYLAVCLVIIVAAYFHLSRIARNFNTEHLELITGLYAEKMNDSM
EYLQNYVQEDIKMIRSMENAQPEEILEQLEKNLDKTVFGDIGFIMNDGEIYGSSSCAVSD
IKKKKLDEAALASDTSFNSDPYQSSRTGNMTMTVFVPVGDTSLVHTLYVSIMIENLRQLG
EYELLQGKISIHLLKADSENFITCVSDNSGPSGSWNNLLLQQKYFQYDAGYSYNQWIKDM
RSGKKDGRFSAIIRGEESTISYRSISVMPGWYVIVELTNKNISDITQQFSAWGGVYGSIL
VGFTMLYMLTIVLLEKKDKKMYMGLSTTDSLTGILNRRAFQIAVEEELRGKTPGVFIFID
VDNFKIYNDTYGHNNGDFCLKYFAKTMKSCFPEDSIIGRYGGDEFVVYLKNLTGEMARTY
METFQRMISQLTLPTGEVVELSASAGGAAFPEQGEDVMSLCKSADMALYKVKQNGKADFK
MKGM
>A0A8D9PPR1|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALGCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGGSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A1S1V5L5|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MKSRRKLTSLALLIVIMMMGVRTAHSSSESYLNLSGTEYLYIEEVNPIKICVDPDWYPYE
KIDESGNYIGIASDLIEIISVRTGIEFEVVQTEDWNQSLEYSKLGKCDALAFLNETEERS
KWLKFTDTYFSDPNVIITREDHQPVTDLASLENKKVALPEGTSVEERIRSKFPNLEIVVV
DSENTAIEYVENRKADMTVRSLSMAAYVIKEEGLFNLKIAGEIPGLDNNFKIGVASGDEV
LVEILNKGIATITDEDLERVKNEHISVNIEKTFNYKAFLIGSGIFATIFLAVLVWIKQLK
SLNNKLRSRQEELSILSKQLSESEALYKSILSASPNAIIISDREGYISMISPATIRILGY
QGDESPVGRNIMELLDRDSQLKAKEDIEAIYRGESTGIVEYIGVRKDKSRFNIESSSDLI
RDEEGNPKDMVSVVRDVTEKKKIEEELRKSEEKYRMLSEELQRKNEALSESSIVDQLTGI
KNRRYFDQKINEEKNRADRQGTKFSIILFDLDKFKSVNDAYGHDIGDDVIVKTVEVISKI
IRQTDSFARWGGEEFTVLMENTGIEGAIEEAERMRSAVENIEHPVAGKVTISIGVSEYTL
GEKVETLFKRADEALYEAKRSGRNKVISNV
>A0A4Q7RYC5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus agavae|TrEMBL
MTWRKLLPTPRWLPREALMHPQRVVVVGFGIAMVLMISVGLRDLYLLRDRVLAARQHDLA
LRALGIEAVIAAERFKAEFVRDYAQQLIAIQQGPNALPTDPVIEQTYAARNQPVWRMAVP
DGDASVIGVSPEKLAGLEGFTRRDADLRADLHAARQLSHVLGISQRTNEDADNIVTFISS
NGFYVTYPPRTGSAAAELMQRFSTMPYYRDQLPDRNPERILRVAPVYKQFESNRLRTTTL
SIPVYVADRFRGVVALDVELPRLRTLIGAPEDRGAVRYLVDRNGSIFATSRGAERTDLRW
PDDMGERWKHTPLVELFARDNGMLHKDGQYLLFQQAGGRGNWIMVDTVDDSAIYRAVFRR
TSLPLLAIWLALPLLMLVTLRVVNHLFSHYLAAGARLQELSDTDPLTELANRRSFGNRFN
HEAARRQRDGEPLAMLMVDIDFFKRVNDRWGHASGDRVLQALARALRDNLREQDIPARIG
GEEFTVLLPESTLAEASETAERLRGIMAQLAVPAAPDAPPAELASGPIRFTVSIGVAEAG
TDDCQTLDAMLATADRRLYAAKAAGRNRVCAADAPDGSAAAPTVPE
>A0A1V5CY69|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin058|TrEMBL
MVALNIDHDDLQKVLLQLDQAIYNHNQWYESLLRNLVCRLPYDFRDVEEDAYRKCRFGQW
YYDHASDELRRHPGFIAIEIEHERTHMLAAKLLKTEAAGETISLLDYENFNNSITNLRLE
LQTLKREMEDLLYNHDALTRAYSRIGLLTKLRELQDFVKRNIQSCCIAMMDLDHFKSIND
AHGHLAGDHVLKTIADYIMARIRPYDKLFRYGGEEFLISMPHTDSESGSRVVERLREGIA
ANTIDYEGKKIRITASFGLTLLDPDISVEETVRRADIALYAAKSSGRNCMRIWDPSLHAR
TEEQT
>A0A7W2VK22|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00325|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMSSLPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDAGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTIMHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>W1EXB0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli ISC7|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A729KBP7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 18:z36,z38:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A627X178|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLHLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1S9D151|diguanylate cyclase|EC 2.7.7.65|Chromatiales bacterium USCg_Taylor|TrEMBL
MAGPSIDRRGNSARNRRFVGLQWKGFLWMSCLLAALSAAFYWLSHSHLMHRYHAQREAEV
QSFRRQMSGLVAGISDRLVRLGGTIVSMDNVVETFKRGNPGKNSAAATEARFASLGYEMD
VQRIEFYAPGGERLWRWTPAEAPDLPEERLRAALAHVHAEERPATFLWCEPLCLLHAFVP
VLAEGQDIGVMGLGQSIADLVIEFRALTGTDIAIVVPAAGHGDGILRRWASAVPALTDAD
RLSPFLEKLSAHYPDPADLDGGRLLQSRGTSFEVQRFPLAEFIPAEPGFILFISDVTERL
TEIGRATRQGLITAAGALAVGELLLLYLVRVLIGRLRWFTQTLPLLAQGEHRAARERLAV
QQKAASFRDEIDLLYDTALTLSHQLEEASQALSAKNQELAEERDLMQGVLDAAQVLVVTQ
NRHGIIQMANKFAAQITGFATVKLQGRRFVDLIADVEAHQEVLSKLDDLYARGQRRADHE
HDLVGRDGTRHPVMWVHTRLRGEHTDDAAVVSVGLDVSERVQAESRMRWLANHDTLTGLC
NRHRFLEDLTRTYDEVARTRVTGALLLFDLDHFKEINDTSGHAAGDALLRMIGEELNFRA
RKSDVVARLGGDEFAVLLPNTDASGAETFAHQFNKRLAEAPFVYANKSYRIGASIGIALL
PHHGSGVEEIMANADHAMYEAKRAGRGRTRVFVDYPPRSENVSKQSL
>A0A4D6P9D1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7G3EWH4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLTGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVGLWKGA
>A0A7Z0VJC9|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MHTLTTEIQERVSKILRENKLLEESLRQSIRLGKLREKALNNLINVERQLKKSEARFKSI
AMATREGIIIVDREARILFWNPAAEKILGYTAADLTDRNIHELLVPERLRSNASEHFSRF
VDEYGKEFESWTKQFPAVRKNGEETILELTVSPFESLNGWQALGSFRDIAHQKLEEERLK
FLASHDPMTGLYNRRGLAERFAQDLKRAKRYKHNITLLLLDVDNLKKINDTFGHHIGDEV
LHRISEIIEYAVRDVDYVSRFGGDEFIVVLGETQLDQATTTAERIRKRAAKEIHSMDDGQ
EISSTVSIGVSMFPDHGHDLDSLVDAADSALYRAKKKGRNAISKAVGEEESKV
>A0A7H9JPF2|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MMNDEFYDNHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQL
LSGVWWLLLVGWVFVWPHLAWQLAFRSTCPHGGEIVNLKIDAIIAGVWMGLIGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRAGDYIGRFGGDEFAVIMSGTPAEN
AIAAMARVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A1U7MGT4|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MRNLHQIGRYVNFLVVAAVLLPLIFIAGVVYVERQQADSMVRVRAEELARLRAVAATAWL
SNQAAYIRGISKLPAVTAGTPNAADELASFITAETGLLALGYAESGGTVQVDTGGRTGRD
IAGSNYFIEAAAGREYQGEVPGTDWLQNGNVTIVAAPVTVNGEVTGIVYGVIRQETIAAR
AAGLVPDIPGGKAPLSRWFFWLGSLYLIGVIPLLLLGWFLRRWQARAAAFPEDAIERQVF
ESGREQTVGMQSPEEAAAEEFETTQNELIAILQQELALASKRSAKDTASESAAGSKPAAV
TAADITPAAVIDRALAAKAYKPKTFGQQAPAVTTLPDNKPAVTPVSQPLHRLQPLIGKKN
TPRLPAVDSLTGLYSRQEFEKIIAARTGQPDSIMLALSINGMKVINDFLGRAAGDAIITA
TADIVKTVAGAECMAARFDGDKFIVLLPAASPDMAEDIKKDVKYHVDLHNLRNPEVPLSI
TLGAAAADADGDLRNVWERAERDMESHKAVNRVEARRFIMWSMKRNRGRS
>A0A157BMX1|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MSQPCFDALNVIKTPVWLISPVSEQIIFANVAATQVMGDKTLDDLRKGIYSASAQTLLSM
YVPELKTEQEIVEIWTLSRDGLDTPLSCRLSLAHYEPWGDVIVFEGISPQILSGLKASRS
ATYRRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDDMCSKHTWEIN
TLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELEHAALRDSMTGLLNRRQFYAITDQSNLNTFPAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSRENDMVFRWGGEEFVILLPHTPLDTALQIAESIRAAVA
RITIPGLPRFTVSIGVARHDQGESIDELFKRVDDALYRAKNDGRNKVLAA
>N8SIU2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii NIPH 715|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A8J7V1J4|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MPPTLLTSTRSRLIAVVSLVLVLAFLGTNLISLEISRQIMRENLLETELPLTGDNIYSEI
QIDLVRPIFVSSLMANDSFLHDWIREGELHPKPMIRYLDTIRKRYDTFTAFFVSEATRRY
YHFSGVPQVVSPDDPEDIWYFRAREMDAPYEINIDPNQAQDNKITIFINYRVMDDQGHFL
GVTGVGLELDAVARIVERYRQLFDRTVYFVNADGLVTVHPDQSQVYRQTLGEIDGLEAIA
SDILGKDRGAFQVERGDQTILMTTRYIPELDWWLVVEATESDVMGNYQAGFLSNLLIGLC
AIVITLIAVSLAINRYQRRLEQMATTDSLTGLANRQLFDDHMTRAIGRARRSGRPISLIM
LDIDRFKSINDRHGHLAGDRVLSRIAKLALSTVRRSDIAARWGGEEFVILMENCPKAEAA
RVAEKLRAAIETLPVAETLGKTDADTPFPDEVLTASFGVSSRIPSRSADIEDDAHVTEAL
LADADAALYRAKSEGRNRVGG
>A0A8J7SKG3|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MSKHGLILLGDPSPERVEARQGALHALGYRCLAVSDRAALPEQARTRAPDVILIASDGEA
EDAEALHLVDILKHDPITAAIPIILTDATDRRMRDGALAAGVDDLLPADSATKEIAARLP
RLVRASVMQTELSRRVESAGRFGVDVDPTGFSRNYALRPRIMTVCENGAILTDLQQALLM
AGFHAIPERSAFRAGERIDDERVDAAIIGVEGPRDIARAASLAAHIRANPRLFNLPTLIV
GPAIDDAASETLYKAGVSIVLNEPVVPTPSTGFIPYMHMLVNRQRWRWTMRDPFKATLSS
GTADVELNGVYGPAFMEEHLARLLQARAVREGMLSLGLAVIDNAEGVRDTHGDEAARILM
QQMAAWITGMTRIEDCVCRMDANGFAILMPETSIAEAERVLHRIAGILHQSEFHLTEEVM
EPIRVWPSVGVVAAGDGDDADRMIERARRACL
>A0A377GNK7|diguanylate cyclase|EC 2.7.7.65|Fluoribacter gormanii|TrEMBL
MKSMDDELKNKIVRTIKFYEENCDTMQNEIKHLRKGISELARLQMGFSSDWDDKVCFFNE
VINDDVDAIIIKQKLSSVVSALNTLLEKNSEKIVDDSDLTILSKKINEHLRELLHCLKTP
PEFANQLVAIEKTLEHNLNASLLIQVIDEIKILAIELFGKEQGQLKFLLEKITTQLFQVN
NYLKTTFEHNKNSKEERNKLELGIQTTLDNIQSNMSSATSIDQLIDYLNKSLNCISSQIQ
SYKEAEDLRLQSYESQINELQKKMMSFEEENAQMKKTILDQSIQINLDTLTKIANRNFYN
ISIKKAYSRWQTTGVNIVLALADIDHFKNINDKYGHLTGDKVLMKIASIFQDSMRSIDFL
ARYGGEEFVIIFEGLSLEQTKAKLESLRCEIENFHFLFRGNRVPVTVSFGLTNIIQGDDT
DSLFMRADEALYTAKNNGRNQIVTWEGFVA
>A0A447T5J4|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSDHFRSGDIVCRYGGEEFFVLLPGATLEAAYAKAEGLRRAVGERPMEALGHSLAVTLSI
GLALCPLHGSDAESVVRAADEALYQAKRQGRDRVCVAARLQSLLS
>A0A564V230|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A447T5H1|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MENGMPPDASPWHRWGRTLAGQLAAAAGCGGGGLLLGLCLPAEQAGLQQLGLPFALALLL
LRGGAGLWPGLVVGMGWLAWREPGPGWAGILLLSASGASAALLGASAARTRRGRSKTWRG
AGLPGRPALLASALAALGRLFAMLPAHGQASAQLLAELCRAWLGNLAAVLALTPLLLLAG
MPTGRRLRPQTVFAAAATLGLALWLGVVADGRGGDRALLPILLILPLLWLAFHGRLLLAH
ALSLAIVASALAGVRLGQGALATGDAGHGLLNVAVLCIVQSATLLAFGVLLAERRGVERD
LLLAKRGREAKAAERTRQLAESEARLRLMADAAPFPLAMNRLAGGELIYANARAEELFGA
RLRPDRPLRVQDFYADPAEREKVARALLEGRAVRDREVRLRDAGGRPFWALVSCELVQSG
ETWYVINGVNDISERKRLEQSLQDANAALRSHLREIELLQQGLREQALRDPLTGLFNRRH
LDDILPRVLAHMLALHREVAVLMVDADHFKRINDTYGHRCGDAVLTALGPA
>A0A419AG92|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQAAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRAHSTTTLLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A3N6DZR1|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI93-02|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQSVADGIVAGLGYELGCVNLVRPDGD
LVVAAFAGNSAAESLITGRVGSRESWERRLSMGEAWDELRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASGGGLDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
TNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYLWVSLR
NSVVADTTDGPRFLLTHVEDIEERKRNELNLAHRASHDALTGLPNSAELRSRLGARLCER
PHSVTSSAIEALDAAYGDVDSPAHGYRADGYEGEVAPGVGPYDHHVHIGAPDPDRDDGTK
GLAVLFCDLDGFKSINDRFGHHAGDAVLIEVARRLTTCVRDGDTVARLGGDEFVVLADGL
GAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTEEEVLHSADQRMYVEKR
SRSKVHRRAG
>A0A448S6N3|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MNSRSYQQLQTSKQRLSLFLFLLMNAASAIFTLFVPFKETPALTLPLICIPAICLAAMLF
TLYSPRHYVQRLNLLAIILGLLWAAHIYCKSQLTASDNHSFLLISLFSIFFISAISLTDN
LLAFCLHAVPSALIILWLDGMHNTMRILFTTLLPIVAFSVHHLLLKRSEMFTQHLVANLY
HERDKFSDLSMIDPLTGLYNRRGLESKLDQLLSPTSDNHFVLLLDIDHFKVYNDRYGHTL
GDQALVQVATAIRDAVRSRDIVVRYGGEEFLVLLTNVGEDYAAYLAEKVRQCVQELTITH
RFQAQETTKVTLSAGISALDKLDIDSAICAADAALYRAKNSGRNNIQLAPHPQPVV
>A0A5K1HZG7|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MSDQDPLPPLEWDPQGVQIQGFSAGLYQIEWLLVTVVILYLVIIGLPDEGALGVLAATFG
YFIFSLLASRLRFFGERQRWLLALHTWAMIGFITWFLYSTDGVTGPLASLYLLAVVTSAL
TLGVVVTMLEVAAIAACQLLLLHLLGTELLTTANLAPVGTSIIALLIVGYLTASLVHAIH
VSNRTLLKMASRDSLTGLYNRRAFDDLARPIHEMARRSGRPYCLITMDMDGLKRINDTDG
HGAGDQAILGLTEWLQACKRSSDVLARYGGDEFVMLLPETNASGGKHMMERLIDAVKDDK
LSISVGIASYPEQGGSLEELFGHADSAMYVSKASGGNRVSIQSVA
>A0A1Y0NB10|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MYTTGHLRLDAATLVFATSLLAFSLANLCALLARGAASKRLGLREWSASLAFASFAFLLF
FFRGKAPWVLTYLVANLAMLAVVPFTMLAYAKLLQVEAPASSVALSSAVGLSGVLAVYFL
ETDAQFGVFSMSMAIGFQLVLAALMVAMAPGRHGAQWRVVLNIIHGLSALAFFVRAGMAL
NGQAMLVSTVANSPAQIVALCVAALYFTVATVVFIVMVSQRQHHEMSDRLRRDGLTGLYT
RTAFFEMAVAKPHQWQAGGYALVLMDIDNFKRINDSYGHAGGDAVLAHAARMLSQLTRLS
DIAVRYGGEEFCVLLHACSAEEAGRFAQRLVDEAGRQSVRIKDGRNVRFTFSVGYACAPD
GQTRGGIESLEAVIDSADQALYAAKAAGRNQVQSSSGIPACNEVALAV
>A0A086ZIX0|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium boum|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVEAAETGEEGLELFTRGGADLVLLDVMLPGIDG
IALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
SAAQTPGAQDDDVALVCGDITMHVGEHQVTVRGQDVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSNYVGDTKTLDVHVKRVRAKIEPDPSHPQYLTTVRGLGYKIDTPTTK
>A0A1Y5S363|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MFIVTFVRIFNLLVGNPRTLWRRYLLAMLFVGVFIAGSHLAQMRAVEAAAQDATIINVAG
KQRMLSQRILLLALTPEEERTPASDAALEQALWTFSTSNDWLVNRPHMSDITRAHYVSEG
DLDQMSRAYIDLTRRVLTEPDGARLLPVLQQASVPLLASLDRAVNLWETDARGRTDALTN
QSHIMLAIACTILILEGLLIFLPAQYSVRRTLAEMERSHEEITAKTQRIEAIAEDLHHAA
FHDTLTGLANRAQLFSVLEQALDGWLDSGAPVAVIQIDLDHFKAINDTYGHPAGDYVLQE
ASRRMAELVRPQDLVARMGGDEFVVVAPFKHWEDVNEQLEAMGQAMIAEISRGVQYDGID
LTLGATIGAALAGPSAKTSDELIAAADHALYLAKNAGRGRLCIGDFVYEPPLGDVAA
>A0A0S4KV84|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira inopinata|TrEMBL
MRLRTERAAPLSLVRSGNGAPREIVAREMVEGAGQAVIGRAGDESAAIGEIGFRERRSAK
IIAGGTALALVEAGLAPSNCAMETKDPLTGLLDRRTFETLLHRRLKMWLRHGVPSCLLVL
DLDYFKIVNEQLGWNAGDELLRQVADLIKKNVREADSVSRYGGGSFAVLLPEADLPHGVG
TAERLRDEMERHAFVLGQGQARMTASIGVTSLGRAAIESIGRWMAAADAALDQAKSRGRN
RVVISESSPFVPAQAALCLAA
>Q0T172|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0E1SWQ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 53638|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5P9CR02|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MLNSLFKKLFVLSTTTLILTLFIIVSFIRVSAEQKKTKIELDQIIDLQLSVDLLRSQLWF
FLQFGDELSLNQVELAQAELSVKLAKYKKESTQLGNIQRMNHSLNALLTKEIQLYTEEGI
VSNGKAPESINSIGFLHSRYNMIVQNMTEELAYVHKSVLNDNTDNVHNVMTYAAAWLIVC
SVLVSATAWLILFRFKAGVEAMKKAIGDLAAGKLDSKVEVISMDAEFREMAVFFNDMTHT
LRDTTVTKQELEDEVKRQTKQLMRKQEQLIFLSEHDPLTNLMNRRAFDKALESAIVKANR
SNCKLALFFIDLDEFKSVNDTYGHDAGDAILVEVSKRILTAVRESDFACRLGGDEFVVCL
DLLHDFDIVSEKSKQLLEAISLPIEFNGHKLKVGASIGVSYFPDHTRNKEVLVNLADEAM
YCAKQIVGSACYDGQESETKRLPRQYG
>A0A6H0KI95|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei|TrEMBL
MEKPSWLNYLSRRTNPGRVVNYCFIIVLLCSTLLTWREIVVLEDAYISSQRNNLENVAHE
MDAQLQFNVDRLFFFRNGMRSAVEIPLGFEVLRNAKDDFEHKRRQPEWTVLIDKSRTLPV
YGVSDKFVDETSILNRDNPLRDNELTATLELGYLLRLSHPSQRLADRMLYVSRAGFFLSS
NPDENPKSVIMAYYGLVTSPWFAQQSQRNNPARGIRWYTQPAPKGESIEASLVTASLPLD
FKHYWYGVLAMDFSVSEMKNFLLRAVEGEEEGEYQLYDSKMNLIASSAVGADIIHLDKLE
EAQLANDFEHDNRGGLRLVTRYISWEKLRNFDGVLLRIHSLNEGIRGDFGTITIALALVW
LLFTSMLLFSWWLIRSMVANMTGLQESLQWRAWHDALTRLYNRGALFERAVTATQECEEK
LLPISVIQLDLDYFKQINDKYGHQAGDRVLSHAASLITSKIREADIAGRVGGEEFCVVLP
GASLRTAMEAAERIRERIHSRELLVGKGATQRISASLGVSSSDETGQYDFEVLQSIADKR
LYQAKQNGRNQTCGADDS
>A0A0R0LIM1|diguanylate cyclase|EC 2.7.7.65|Ferrovum sp. JA12|TrEMBL
MNTVFFIFLVFGVMDVFFSIILYLYLHDSLQSNPPLLNVANSKITGGLALLTLTLRHFFL
NHVSSIYEYDFFLILSNSFLFMATLLAVNAFKSIINKPSIIIYSHTITFLTAFSFWSLVF
ILNIKPGLRVVIFSLFLLIMTMIVSYDLVTYKNTKSYLLNFFKLTFFFNGIFSVLKLIKG
LNNPNYSILEDSNKVDLLFLVLFLIWNIIIYFGFVLFSKAITDVKLITQANTDYLTGLLN
RQAFFNVAEKVFSLQTRKKSSLSLLYIDIDFFKNINDSYGHTTGDNALIVFANLLTQTMR
KSDFITRLGGEEFAVLMFDTPPEMALVVAERFRKDLESLNFNDKNNNSIKMTASIGVYGE
KQTQHSALEYFLERADSALMEAKRKGRNRVINYDLLLV
>A0A1C5ZZL5|diguanylate cyclase|EC 2.7.7.65|uncultured Flavonifractor sp|TrEMBL
MGGHRSKNNIRFAIALTAFLCYLVAAFMVFFASVDNAVNKNTVELLRSNVQQQSYHFEAV
IDLQFNTLEVAASYIGMQPQRLTLEQMEDVLQSLSSTDTFGRTMLILPDGTGYTSDGVTT
QVKDRAYFTTAMSGKRALSNPISSSVDRDNKVVLAVPVRRNGEVTAVLGGSYDVGALSNL
LFADIYDGKGYSFIVTADGSVVSSGTTYADWSGRNFFDAYGKVKYSKGSLEQMREDFQER
SGGSIIVDNQGVGSYLAYEPLDCNDWVLCYVVSEEDAKASYVFITHYELLLGLAFLAGVG
ALLLTMQRLNARDRRRLMQKAEEDPLTGLLNKESTARSITDWLNEERCKGFQVLLMVDLD
HFKEINDTYGHATGDLVLKKAAQVLRGVFRETDIVGRVGGDEFMVFLKNVGNPEVVQRLM
STLNSRIRSVTVDDLPEETLSCSIGAAFYPRHGKDFTLLYENADRALYEAKRAGRNGHAV
FESGS
>A0A2N7RJP3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MNLAQDIMENQRGKGLSFARRIYLPRVIGLGVGFFSVAAALYPLNMPSWLWALLVFNGFV
WPHLAYQVSTHSTFPYHAERRNLLYDSLCGGFWTACFQFNPLTTVTILSMMTMNNVAAGG
RRLFLFGALAQLAGVLLGWSVFGFTFSLTMTQIQVWACLPMLTLYPLALGLVSYQLAIKL
AQHKRTLRDLSRTDSLTGLLNHGAWKDLLHSKFELCRQNHTLDILALIDIDHFKSINDNY
GHIIGDAVLRHLARSLKQLAEGEPAGRYGGDEFCVILPDQPLHKAEARMEHLRQALQQYH
HPDVPELRVSLSIGLARFQPSYSDAIAWLDDADKALYTAKHTGRNTISVALGRPSSNDAS
QFSL
>A0A645J0E8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MSAILSAAVGSSGFVGRWGGEEFLIVLETDEPDTILGKINEIRMAVEQYWHEDIGKNISV
TIGLCRYLESKSVDTIIANADKALYQGKMAGRNQCMIAT
>A0A2P2E882|diguanylate cyclase|EC 2.7.7.65|Candidatus Phycosocius bacilliformis|TrEMBL
MVEKVVQNLIGEEGVAVAQAALDSLKEHSITPSPENYAVWLAFHTATPEDLKAELDMMIA
AKRVIDDLACDQLYTKYFEDIGIGSRMMKAGGKIAAEMEDVRRGLLKAGVKTKAYGEQLE
IAKQELAKTDSPLITKNLVDTLVGATTEMATQSKDLETKLAESSIEIEALRVQLERVRQE
AATDSLTGLANRKEFDSRLIEMCAAADRGDGPMCVIMADIDHFKRINDTFGHQTGDQVIR
FVATVMDRAKPKGGIVARLGGEEFAMITPATDRKAAIAIAEKIRLAVESKRLVRRASNED
LGKITVSLGVAQRRTSEKPTDAVERADAALYQSKRGGRNRVSQEELLKSKAA
>A0A645BI61|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MVLDVDKFKIINDTYGHNIGDVVLKEIVQAISHITRDSDKLIRWGGDEFVGIFYGLSEEN
AIILGEKILFEVANLKISVGDNSISPSVSIGFSYFNKNDQEYTDALKRSDEALYKSKVQG
RNKANIIV
>A0A822PQ48|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>E1JCQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 124-1|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYITKRRGRNRVELWKASL
>A0A822PIS0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A378SFP9|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MVDGTVRTLLRQWWNQRDDYQWRIDFLRTRGLLPVLRYIIAGIGGSLGVLSVYNAFVPPG
ADGVLIRTGWAILAVGSLGWAARWALGSWPTVRESAALVVFVDVMMTVSALLFGDPTLAM
SGIPILLCAGGYVVFFHGPRLHLVHIAWCTASVVGIAIWLAVSDPVFGPQLAVSRAIIAL
AVTVCVLPALQFGFWLLQDSSMQSLTDPLTELTNRRGLAVSVKRLNTDARADATLCALLI
DVDRFKSVNDTFGHAVGDDVLIRTARRIRASVPEDAVVVRWGGEEFLVVDRIPGNQAETV
AERIRAAVAEPAEPTVTVSIGLATCERADIDLIDVISAADAAMYKAKADGGNKVVITADA
A
>A0A2H6GJA4|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin14|TrEMBL
MPVKGEYPVRIRNVMTSNVAEVSPDTPLFTVCTMMRERKISCVLVRDGKKILGIISERDL
VRTIAMKGGDLRGSTASDSMSSPVETLTTEVTLENAVRLMNEKGYRRFPILNMDGVLTGI
VTRSDVLRAFTRELEVAHEEMKDRAIRDYLTGLYNRRFFMAVMEKEFYRSKRYDVPLSLI
LLDIDDFKKFNDLHGHQYGDQILRTLSEILKRLSRTSDIISRFGGEEFTIIAPSAGSKQA
AFFAERLRAALHEAGITVSIGVISFPEVDLKFPDDLVRRADAAMYYAKEHGKNRVKVWDC
DMEKVEAPSSTS
>A0A0J1IKN3|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MDLVAELTKRRVMEGELQEKETTLSTVLDAVRDAIAILDDHGNVTFWNTAAEKLFGYPQE
EILGKDLHLLVVPEEHLYETYSKAYNHFKTTGKGNAIGKIMEFKAKHKDGRTFVVELSLS
AMRIKNTWHSVGIVRDITERKQEQEELKNSRQKYLELTENAPIGIISCDYKGNIIYVNQI
VLEILGSTSIEETKKINLLTFPLLVRHGLSRQLEECLKSNKSAMHEINYESKWGKKVWLR
IHIKPRKNRNTVIGAQVIIDDISERKQLEEKLFLLSITDSLTSVYNRRFFIQKLEEEIER
VKRTGRKFSVIMMDIDHFKCVNDRFGHNCGDFVLRKIMSETIKKIRKIDTLARWGGEEFI
ILLPETTINKAVVLGEKLRERLSRMDIPNVGNVTASFGVAEYNPGDTVDTIVQKADDMMY
QAKSAGRNCVRYIRE
>A0A7W5Q0X2|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK313|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAEDGLKALAICDSTQVDLILLDIMMPGID
GFDVCERLKSDPRTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRMRSETARNFGIDDLLRLGDGRADENGHVLLVDGRANSQERIIRALKPIAE
VTATSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
EMIVRALDLGINDYIVRPLDPNELVARCLTQIRRKRYNDRLRASVQHTIELAVTDALTGL
NNRRYLDNHLKILFNRSLTRGRPLSVLITDIDRFKQVNDTHGHDAGDEVLREFAARIRST
VRGADLACRYGGEEFVVVMPDTPPEVAATVAERLRAAVETMPFTLRDSGVALNVTASFGI
SSRLETVETPEHLMKQADRALYEAKNAGRNRVVAAAA
>A0A3U8MR13|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1T2ZEL1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAPLLRQLKQAYFMNGLGLGQDQDCFIEEQVRTDRLHQLFRQSFAAIFGSYLGAGMLCWL
CWDRFDHTVMRTWLVVLGVTSLLRLKMFMDWFRCANSLRTPARWERRYWVTLMLSAATWG
IGALAVMPPDDRVSQVLVILFAVGMSVSAVSCYSAYRYMTLGSMSLVLLPSTLWLLFQPS
PMQVGVAIAVLVFSTFVVSATRKLSDALEKAFRLTRQMERAHTISTRAAQTDELTGLMNR
RAFFEHAHLLYAQCRQHRQPLSALMLDMDHFKAINDTYGHQAGDQVLRQVGGVISASFRQ
ADVYGRLGGEEFAVLLPNTTLETAQGIAEQLITAIAGLASEPVQGLTASLGVATTRNPDQ
DLHSLMNSADKALYRAKAMGRNQVVVAE
>A0A0H9LSP4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGGFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPLTVML
LDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGL
LMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKK
DGRNRTSTMRYGEEVV
>A0A0B3BWH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas flexibilis|TrEMBL
MNEELLAQEWQALIRQYADALPILQSLAETHRVALAREFYEQMLENPGSSPYLSHEQVRT
QLSSSLQRWIINVFAAQQTEQVIECIRLQQHVGKVHARIEVPVSLVLRGARQLKTHLSRL
LMDSGLDDHAQHAATRLACQLIDLTMEIMSQAYSLSHDRNSRAEEAYRLFSVSQNLGTEK
ERQRGALLDWENQLMFALATGQQASYLPKLSDSEFGLWFRHKASHAFQGSPESTSILTYI
RAIDAQLEDLRSQEHGGRSDLPIDLLRQIREQTKSIRFLLDSLFEQANDLEAGRDALTHL
LNRKFLPVVMSKEVLYSRQSGHSFAVLLIDVDHFKQINDTYGHEAGDQALQQIAGLLTSN
TRGGDYAFRHGGEEFLLVLVDIEPTRALQVAESLRQRIASESFRIGGQVLQLSVSIGVAV
HDGHPDYQRLLRRADQALYQAKRDGRNRSVLLAS
>A0A7U8X0K2|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVMLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3V2W4T1|diguanylate cyclase|EC 2.7.7.65|Salmonella hadar|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F8WKD8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MELRSTGKSRTNHDVPLQHERSSTPPIVRLVALGVVVIWLAFVAIMGWWVAQRRTAEDLD
NLAASAAYEAQITARVVDRLFTEMTSVANMVARQNEVIQLATRYRYDPPSFAPLTREERA
SILTKDPLVRKVGDFMDRLSRDLRYARIYMNNLSDDTVTASNWAESFSIVGQIYSGRAYL
IDALRNGRSEMFGIARLNKTPSYFVASRIDDAEGMPLGSVTVKFDAPDVALYLTGRHIAL
VVNLQGRVTTASSELFMLRNVAALLPPEIRRPQENDEEVGQAMDIRAIGATDMDGLWSID
GQPYLVRRHPLSNAQYQLLTMAPLDHQEAMRAQTYWMSAGVGLLGSILILLSSRVAGQVL
IRRREERYAANHDTLTGLKNRRAILADLDQYFALAKRRRQGVLVAFIDLDGFKTINDTYG
HEVGDLFLIEGSRRLLGGLRATDELGRWGGDEFIVIGLTESTSPSDMEAATASMRRRLVP
LLMGNYVFDECSFEYPGASFGIASVDPSVMSLQAALKIADQLMYADKAARRGQRMTENGR
ASGSDDCGQTDTLA
>A0A431XGD7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKIGDNGLWPGMRTGALFFLAALACIYLSRQPATIAAIWLPNAILAAALLRAPLRQW
PMILFCTALANLAANRLYGDSLWMSAAFLPANLSEATFAAMLLRMNRVREDFDFNLLSAV
RVLWAGALVPPLLGASVGAALVSLFGLGSFPQMWARWYVGDAMGMLALLPLCLASSLATW
RHGLSGRAGVDNAMLLLATLFISFVALTRLPYSFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIAMGVFAPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGTALVALDGRLFKVNEALCRMLGYPAERLGELTFQAITYAADLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGIAQYFVTQVEDIDSRKRAEL
ERERLAERVKLATDAGQIGIWEWDLRHNHLHWDFRMFDLYGIRSGPGETTVEQWQAALHP
DDHERVLHELDRALSGLQKFDCEFRIVRPDRQVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLYEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDALGAPH
ELVFNVLDSDTGDTLDSPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELRRALANAQERASQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAVA
EEVASKLIEQICSVRFPWEGRVYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVVARRDGGRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGPRIAAIDGLTIGINLSGNSL
NDPLFLPYLLDRIEHSPLGPERLYFELTETALMNQLSVASRIVDKLRDLGCKVALDDFGS
GLSSFNYLKNFAVDAIKIDGSFVRNLDKSPVDQAIVDSINQIAQRLGAVTVAEFVESREI
LDHLARLGVDYAQGYAVGRPQPFATVLDQLRGARRQGLG
>A0A2T3QBJ1|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MADLRQRLRYTAYWLVSITIIVYGWFYFGGAEKELVITPKNSTFRLIDDSHQGGASTAEL
DINPDGAILNCELVKKSQWPFCEMAISLSDSVAKGFDLSKYHAIGLDIDYDSPVEGERVR
IYLRNYDESYSNETDPVSLKFNAIEYAPGKDQGLQVIPLKSFQVLSWWIAEYELPIEKAG
PQFDNVSIIEIATGSYVKPTHYGITLNKLVLYGTWISEENLVKILLVIWILTALVFLTTE
RIRLYKQIQNAEQKAARLKTMNKVLFEKSLRFEELAYIDPLTKAKNRNAVSDWVRQVVEH
SKDMAQPFSVIYIDIDFFKKINDKYGHGRGDEVLAKFADLLRRNIDKSDMLVRWGGEEFV
VFCPSTSLGVVAEKAELLREAIAEYQWGNEFSVTCSLGVAQLENEEFNRLMERADEALYK
AKERGRNRVEIAWD
>A0A418Z978|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Mbandaka|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Z0CK98|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Haifa|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3W0FLD4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Litchfield|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2I5HE17|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A291DY54|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MSPLKYINTIILIVILTTLIFAGFVFREYRDLKSYMGYIAENGKSALFHEEYINQSAAFR
LSRAFSSAPSGITNSANKKIDVCKYAESLNGVYGLNLASQKLPTLQGTLQTRNPSCASWA
GDAAALIVVQDNASRAVSKYSFSNYSGYVFNNTRYYIDLKNNYIYINKVVDTNHYTFNNW
LVSENGRIDIDRSAKTINIDDSALADLRQGENIVSHVYKDGYTHKNIISMITPVFQHEEI
KGLFITDINIDDLATSFYTAERPLLWHFLSLYVTDNATGAKISFHHPVLKSFTPISYEEK
ITGYYTLHIQLDGIYFLIAILWLVALYLLGTWLLCRYAQKQLDRNRSLSHDNMTDAMTGL
YNRKVLTSSLEQKIHALLNNNIAVTVISIDSDGLKKINDTLGHHMGDRAIQYLGRALAQS
IRKSDYGIRLGGDEFSLILIDYSLTKSNEVITRIHDYLQTIDEDKLVGFSYGSYQMAAGD
TLETALLKADELLYQHKRDKYGEKGSSR
>A0A4V1IDR3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A291DX93|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MQKRFPLYRYNSIPKSYIDGNYILAGRSWYERLSVKSAFVNYSEIYANAVDGLPVVTIAK
LLHDDKGERYGVFAMDLNLSNLSHVLRQLESPSEGHLSIVDRKGRAILDADSDTIGTPVV
PLAAIHRMTNGLGSFHDKVTSKHYYYYSFSNPDWFVVFTVKDKVIDEYTFYYVWIILIAF
ASCLTIYLLLWLFMRQSIKAMIVDIVSMMRFGRIELKDGVDKGILSEIGESSRQIKNAKS
ASLTDGLTGLLNRRSFDNDVNYLLTREAPFSLGVIDIDNFKKINDGYGHLVGDTVLKVIA
DMGMGLLDDHAKLYRYGGEEIAFIYFSDNQVKAMDIMESWRKRVENKTWREQGLAVTFSG
GLCPWRGENYERLIEKADKLLYKAKSNGKNKVVISTS
>A0A0T7RPM9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A381GEA2|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MTAQSWQTLRTKKYQLSLRLFLFLNAVSALFAVAFPIFPSKTISTPGSLILVLSTALLTW
HVKYAKKRINLHAISLLFGGLWAAHITLKYLAQQNPDYSFLLVALLTVLFIGSIAFANNI
IAFTLHSLPSLFVCLWLNGHEHGLQLLFFMALPMAGIAIQHVIQKRYDDFAQQLMFKLLA
EKETLTDLSMLDPLTGLYNRRGLQHKLKAVLELDTHEHYVLLIDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDVVARFGGEEFMVLLTAIDPQTARTVAERIRQNVYDLKIPHM
FNESVATHVTISIGIAPLVGSDVEGAILHADQALYKAKDLGRNHILVSDDPGIA
>A0A3U3AB87|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5I8PE88|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5V7ZBM4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A484PH16|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MKHSTEVMALDWEHTHSRYSAEQCQLAQDVSARHTAALADDFYDCMLADQGAAFFLSHEL
VQTRLRHSMQEWLLTVFDARHLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLTRRM
HELLHAEPDALPDAVLGACRYISEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSADLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHHPPGSAQRAQALQGIRDATQAVAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPLSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGPQALSVADALRRRVQERPVALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAADDTDMPSGAPASHAAGHQPVRAGA
R
>A0A3Z3G611|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGAHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3R1D8D7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEIAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0F1WT27|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMHDAIETPLAFDVLQDAVSRFNTVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDRAGDITARYYNLVTQSWFTQQSERNNRARAVRWFISTPSSWTGDERTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEDRTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAQAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDYFKNINDRFGHQAGDKVLSHTAGVIASALRKNDVAGRVGGEE
FCVVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSADETGNYDFEQLQ
SVADARLYQAKQSGRNRVVWRDQDRK
>A0A7X0DRL2|diguanylate cyclase|EC 2.7.7.65|Rhizobium leguminosarum|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKANRKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLMRAGEGRADETGQILLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRCNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAVENAPFMLKHAGEALNVTASFGI
ASRIGSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A5I6CDB5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hull|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7Z8BU29|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESLNITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLCWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLGQLINGEINSYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRPHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGNTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQHHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITKGPLPARLLHLAIAADVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A4S3D8X3|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A241QF91|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTDPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHAHKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A0W8AZH1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEKIHTECSAIM
QDADERMYEIKKGKR
>A0A7W2WN78|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVKDDADYSYLSKINAAHEKMHLLGKDLLSVIVAERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRNLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITRVRQGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
RITTLV
>A0A486UHS2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNR
VSRMPFDSSERRRSRDGAA
>A0A372HRR2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKMLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRELNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGQGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLPGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>J7QDA9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYYAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>C3T4N7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2T3SE14|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8H2AUC8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0J2BIX4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A853T1S9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MRVPELSTLRRIAVPLAFGGNSEQQHTYFAELHRVGLITQVMGIIAFSLAWLLMPPAYHP
NLTHAVLALLGMLASLVVRARCTTLPVLTMTGACAVLALTFGLRTMADAVHHASFWVLPV
GVFMTLAIASIFNGGLSYLAVVAGVWWNVGHGLYPVNAGLPDQPWVPLMIAVSVLFGLAL
NVSFSLLRLRNYHAKVELTRLAFQDSLTGLNNRRMFTQRAQQMHGASHGGMLHFLMIDID
DFKIINDQQGHDAGDAVLMRTAAIIADKAQSHLCGRLGGEEFGIVYAGDREAVRAFAGAL
VAAVSQAFHAAQFVSISVGVAELDRDKELSHSYRLADEALYLAKRQGKNRYVIA
>A0A1Y5C3J2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLKNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377LD94|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQATAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAENVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7L5NW72|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSHSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A2B7M109|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MEMYFKRMKDEWTGLVAQAAPIIRTKAAEIAVTHAHYLSNEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMEKWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFNQTILHAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASETDTLRTAERIRSRVEKTKLKAANGEDIVLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2S5U5V3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNADPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIHRV
>A0A066R590|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A377CTB8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSAARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYGVQSESEVQQICSALTQIFNLPFD
LNNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8F9FWA9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRVEKLVR
>A0A378AQE6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A066RFM2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>C3TA62|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2G8YH35|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A641D888|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWLGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7L5VII8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGALVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLARCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A828AMJ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0D8WD51|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFPINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A135XBL2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIELLENSPLSPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2J7KT78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A853SX94|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MDSLLKHMVDMTGHRDHTMLDISVISAVQELAAASQTRVLALTTVRGQVFVRSRAIIVAG
SVARMEEHTDPTLPGEPLSDYPALAACIKRHEASADTLCADGRHLLWLPIWIGDQVTTCL
EITNPTPYTGATIQVIGGIVSVYRNFQNLLDYSERDSLTGLLNRKTFDDQLAKILHSRGE
PEADKPRPVDEERRHHTDTERQWLAVIDVDHFKLVNDKFGHLYGDEVLILIANQLQSSFR
SQDRIFRFGGEEFVVLLRSITLENAQKIIDRFRTNVEAHDFPQVGKVTVSVGFVSINAYE
APVIILGRADQALYYAKSHGRNLACHYDELVAKGLLTTIASNDTAEFF
>A0A2S8JJN9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFRSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X6TCF7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A718P595|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain SL1344)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A346J599|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A737N1U1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi C|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A735RJ61|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 48:i:z|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A222UIE3|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MDKPLRLKLKKRYFLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLNQRHQEIWRVALPNRRTL
PVFGVSESVVREHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTHYSRAISALWFTRQTQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMKGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMALASACQR
SGLPLAVIQLDLDHFKSINDRYGHQAGDRVLSMVASTLAGTVREGDLLGRVGGEEFCVVL
PNTTLQEAAAIAERLRLRIHGREVFLHNNVTLRVSASLGVSASEEQGEYHFEALQSVADG
RLYLAKQNGRNQVCFRSEA
>A0A4U9IDG7|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNKGISSAPRPTFKRTLRRISIISVLITMTLVWLLLCIASVVTLKQYAQRNLELTSATMS
RSLEATLVFNDAAAANEALASLGKQGQISAAELLDRDDNRFAAWSMGPNSDADPLSQLVS
QWLFPHPIRQRVWHNNLPIGELHLTARDSLISHFLWTSLAVLTGCIMFASLVALTITRTL
HIGVVTALQNITDVVHDVRSNRNFSRRVSQERIEEFHRFGQDFNSLLDEMEEWQLKLQAK
NAQLMRTAMHDPLTGLANRAAFRIRIAALMNDFSARTHSALLFLDGDDFKRINDTWGHAA
GDAVLIEVARRMVEFGGEQHQSYRLGGDEFAIILYDVHSEHEVLRLCAALTQQFSPSYEL
HNGFSSRMSLSIGYALSWQHHSVEALVEQADRNMYSVKHQRSKITS
>A0A5R1YMJ1|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A750T800|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A701YZ70|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAALVFSDNAAVAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARNSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLHGVHSEYEVQRICAALSLAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4U8J0B5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Chester|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A753DWS8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVDQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAITLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIAHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5W1FRD6|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMYEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V4KKB4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQVGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQERKKK
>A0A5X4NVF1|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQHWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0E2ZCR7|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bifidum|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFDVATAASGSEAIEVIEKTQPDLIVLDVML
PDIDGFTVTRRIRQEGIGAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVSRAGHAIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIMVTDDNGEQHKVTPLIETKRGIGYMIRE
PRVSA
>A0A5X9XCQ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A626AX44|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Poona|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3AEL3|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKRLLKGLSPEGEALLNLIPGGVMQCRNDSSYTIVEVNDGFLSMFGYTREELDERFQNRF
FQMIHPSDQQNFLIEAERQLEKGDRLSLSYRVLCRDGNYKWIASSEKLFGDEKEERFFCI
FLDLTEVRDAQEKLRLSLEHLEIIMNQSSDIIFEWDLIADSISFSPNWLEKFGYAPHYDG
RQQKEEMLHNFYPDDVEPMAAFMEEAKRGISDSVIDVRIRSFQDQYIWCRIRAATQYSAE
NTPIRAVGTISDIDEEKRMVEELRRRAELDALTGLYNHTETERRAELYLADKPDTICAMF
IIDVDNFKLVNDGQGHLFGDAVLAELAAGMKKITRKSDVIGRIGGDEFAMFLKDLPSVSI
AEDKARKLLQLFQNLFQGEKQSVEVTCSIGVAVYPWDGSSYQELYHCADLALYQAKCWGK
NRYARFDAGSMAAMDRIGYSSLGASIDSDQNTGGKTGDLVNYVFQILYDTNDIDDAIKTI
LEIVGRRFDVSRAYVFENSFCGNYADNTYEWCNEGIIPQKEFLQQYPYEKVEGYKDLFRD
NSVFYCRDIHSLTPAQSRLFESQGICSTLQCALYDDKEFCGFIGFDECTGLRMWNKEEIG
ILSLVAQMLTTFLSKKREADRNRQILVQLNTILDMQDAYIYAIRQDTYELLYMNQKLLRL
DPSARPGMACYQAFYGCSAPCENCPLTGAMEVYNPQYGIWAKVQFSPMKWGDDSAYLINC
ADITEYKRMQEKKGSGR
>A0A701SBC2|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSREGRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A517M8V6|diguanylate cyclase|EC 2.7.7.65|Roseimaritima multifibrata|TrEMBL
MISPLTLFALGLVIGALLLVVGAYAGVRIGTKRARADQAADRTRVLTLLQELGSWTHEYS
GNVSRYQDQLDVISKAVQAESQEGPNKVMQLLEQIMRSNKDLKKRLDAAESQLDKQTQQI
ESYLSEARTDGLTGLANRRAFDQRLEEMFSAYRKGNGRSFVLALVDIDHFKQINDQYGHQ
AGDEVLRQVATLIGERLEGAYLVARFGGEEFAAIMPTPLRLAADRADKARQILAAQSLDA
GDLSVAVTISIGLSELRDDMVSGPLVRRADEALYAAKGRGRNRVYFHDGSDTILVGAPEV
IS
>A0A1A9R132|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. ALS9|TrEMBL
MRYKDKHQLAAEWQTLLERTPKPLRQAVETLVESHGERFAEHFYRVMLEDPHASLFLSND
QVEQRLNPSMQRWLKAMFTVEHADFEALVEQQEKVGQVHARIDIPVNLVLNGARQLKQAF
YQQISATFESPLSPGNASVYVSEHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQHDIATLPKLANSDFGLWYLHKACHAFEGAPEIATIS
RHIQQVDREWLEVLLHEDSSQRLEALGEIRDATRTVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLPVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDSVLQQVASIFDRS
TRGGDYVFRMGGEEFLIVLVDTDHEGSRLFAERLRQSVAKEPLLAGADTLLNVTISVGVT
LHDGHPDYHHSLQRADQALYQAKRGGRDRVVVQ
>A0A377RPL0|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MAGRQRRASWRKAHWLLVLACLLPPAAHAQISNLEQYLTAVRDDGRFVPARALQRLQEVE
TQARSAPLPIRAEFLTQLSNARMRLGQNDIAMQLAEELIAYARQNKSDVALAKGMLNKAY
ITFARNERRASHLLAFEAEKIANRTDDLTVRAQATISAGQSWAEEGNFPFALAKLQAAVD
LARQSKSPSSLAAALNALTLLYTQMREYDKGFEVLDELLAVSSTLASPGRMAQAKNTEYG
LALDAQQPRRGQRALLAALALERQLGARGMVAVTLVNLSDSYLKEDDYGQTLRYANEAIT
AARLVNDEQVEATARLNIGQALIGQGRLQEGKQSVATGLAYYERTANQPEMQAVLLEYGM
ALEKAGDLRGAVTAYHRERGISNQLFEKQRQKAVYELQEKYEAEKKQRQIELLSRENQLK
STEIDNRRLQQRVWWLLALVLAMASAIVGLLYRKVRHANVQLKVKNQELKRQSSRDPLTA
LYNRRHFQEFMRSHAGKPQPSYAGGDVVGALFLLDVDHFKHINDGYGHAAGDLVLTTIAE
TLHDVLRETDMIVRWGGEEFLAFLPAVARDGLDDIARRILNGMAAQSIDYQGQTIQVHVS
VGFAPYPLAPLGRPLTWERSVNLIDMALYLAKAHGRNRAYGLRGFRQVERTTLEAVEQDL
ERAWRDGFVDLSVVLGGTDGMDKTETAVSGGQASEGVAAAAIT
>N9HMD5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii NIPH 478|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSKHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQEIMDCTDKNNMLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESVRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNEADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1C5LGK3|diguanylate cyclase|EC 2.7.7.65|uncultured Roseburia sp|TrEMBL
MIQKYYNSILEQVFAQIGKKEHNIVLAKYSNDFSLKQLEISEQITNNKKVHFAAHEFRAE
KLSGAYEPFLDLIFELFDQQKEMTFDEFLDKCNVYSLQRPIIAAYRETGKCIRKESLLYT
EVDYERERMHDAIVAMLVEVSKIQPFMLWINRMQFAGKGTLEIVYELLKAEHTENIGIVL
GMNEQQRLPEYMLPGWESVTEELDNNVAIFRIGNAGESREQRDEVITAESIADDIRTLQN
LVFFMDFEQALFYLEKVDRRIRFENFTVSDEVKYELWQFYAYVSVYMRDLPKALEISESI
LQLAEKKKNRRMRFYAYYIRSVIYMYQSKLQEATECAGVAKNIATEGGMERGQFEAELVE
IQAKMAGWNNIFFCAQNVEVSDAMIEKLIKYDYRNHLAYIYVYAYDNKPEIVAKAYYSES
QLIYFSKGIRLATEIGNTQLIYNAYQKNIMLASSNGMYPIALLYSVRTFEALDNKCSVES
GRIFSGIGYTLTALRQNDLAKRYFQKAVEILYNLELPEDIAEVYYNMAINCIAAEEFKEA
NEYLMRCMKAIERLHLNSLRVCNLSKLYGLLALCNQKLGNRFNCEQYLNNCKQFLNYIIE
KEKLQNDLGIIHDYARCDDDMFLYHFTRALLEMDSGNDSSAFEDFNCAETHLVRTEGNQF
FCYQVFRKDRIRFYGQTGRMELKSNEEAILKQYLEDNTHSLTDEEIKVLEPLEQYLSEEP
LHVISTLEMEMQLKQESINRAYKQERRQMDFLSTWQKTIDVTDVSAEVMVENVMRTFLYH
FNLDRALYIQYHGRKPKVLYDNTEASLSMKEQKYLKEVFEKTQRGFVVSKISSNYSEHLN
VVKLFDEDNVCSLVAIPFFDNGKVTSIMIAYILMKDNWHSSVSRYMLDESDMRIYELLFR
EVQYALNRLYAYEKLYEMNAALYKSAVTDQLTGILNRKGFYQNIGEIIQKIKKGRMKHEF
GIMFIDLDNFKGYNDTFGHDVGDLLLKSMANIFSRVCRDKGFVTRFGGDEFIIFLYTGEK
KTLEDTAKAIYKEIKKQDGFRELIAKEIGQPVEIDDKKLLSCSIGIISSNQVKKAEDIDE
MIKVADDLLYAVKAESKGTYKFFEEQEQK
>A0A1C5WCY6|diguanylate cyclase|EC 2.7.7.65|uncultured Roseburia sp|TrEMBL
MNFLFDTSIDVNRRQFYVLAMGSCIGNLAGFIGNALIFGWNGTTIFCGICMLLMAAGSFI
GIKKGQIRYASYLMIAVLSLVEFPILYYIYQTGTIVYMVLAMVAIAIFIPTGNAIRFAGI
VIVADVAAVILAYMRPLESEKLSKEVVLQSTLCSLLIVLLCVFLISILLQMQRQRQEEEV
KKLNEQLKDAADKDALTGLYNRRYLNQYLGELILDEKEEFDAVLIDLDFFKHVNDNYGHG
FGDIILVEFARLLTKHVKNKGIAVRFGGEEFMLVLKGMNTDEIGKMLEHIRREYKEYTKH
EKNIECSFSSGVQHYTEGIAVTVLYRLADEKLYTAKERGRNQDVFDLES
>A0A1G3GZ64|diguanylate cyclase|EC 2.7.7.65|Rhodocyclales bacterium GWA2_65_19|TrEMBL
MESSNPDLPARDAPSVAESEWIAIVGNTDVRIRELVSATVSENRQQLAERFYSTMLGDPL
ACQFLDHQQVAERLNKSMQRWLQDLFQVAPATSVAASVAHQRFIGEVHARIQLPINLVAR
GARYLKRWISEHLAQEPRLEREALLAASVYVGDMIDIAIELMSTAFVRGYERTARADEAY
RLFSLGQNISIERERQRAALLEWSYHVLYAKHQRSDESMRSLCHSEFGLWLHHKAQVMFE
GSPEVAQINDAAERIDSLILPRLTASQSPADLSELTGDLQRELASIKFLLSTLFDRYVEI
ENGRDVLTRLLNRRFMPAAINREIAMAKRSDSGFALLLLDLDHFKRINDSYGHDAGDLVL
QQAATLVLNNVRAGDFIFRYGGEEILVMLVEIDHASAQRIAEHIRQRFEENLFLISEGRT
VQLTVSIGIAVFDGHPDYQYVINTADAALYEAKNSGRNCCVVGPVLQAMAAEA
>A0A8G1Q3A4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYQ
AKRQRNHYCLYQAPA
>A0A8G7LTK6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQNAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2T3QPE5|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MNQDYQHSLTQCKLFTFFKICIVSLFLFSICYQGYNIYRIENLQQTIISTYQELFSISRR
FSSYYNNAEAKKMNSGTYEKHGVSIIVNQESEVKSLSKGIKKLKFELNRVAPNSIWTIAV
LENPALYGHFDPLRQEYREDYATYTKNSLMNRIVRIEGIEDTYKHFYGCNIKMTDSYLEQ
GTNKTVRTIYYPIYNDKKLESILAIDIKSNLISKIIDRYNKNELTVINNNNKIHNIYNVK
FLIPCASNQPIIIGINYIDILKRSSMLALVFSTIVFIFYLSIENKTHFLQRDKMTGFYRR
DFYENKLNKLDNFSMLIIDIDNFKQINDTYGHKKGDDIIHYVAKRILDNIRQKDIAIRWG
GEEFIIIFNSMDCSSLYSRAEYIRNLISREPICGLDITISIGGLCEQDTTFTESYRRADA
ALYESKHNGRNRVTII
>T0PNM0|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MKLTTQLVSFITLCVIASMAMVLLGGVFSFRELGMELQQKKVNSLVEVIDKQLEAADDHQ
ELTRWLPTLLRSAHVVELEIRQGKQRIYWFRDVQQQTDESLLIPYSQPISHQTGMQADFK
LERPFKEFEYSMKAMSGISLGIFIAIFGLWYSIRWLRLQLRGAELLAERAQLILDNKLTK
LAHDPAEEWPVSASQALDHLLAELADARKERSRFDNFIRSNAFVDKMTGIGNRLFFDNRL
ESAIMEASVMSGGVLLIDLAGLEDLDPELSGRQSQDLLMEASASIAAFVRKHSGALQARY
AGQVFAVLLPNMSESEMVDGAGQLHKSLQRLHWPAAVNVETAVYLGAVCYQAQDSLLKVQ
EEAELALKSARLQGHTGWFLYEKQLDEEQSSKGTVRWRTLIGRRIEEHGIDFYVQPVQQE
RDQVVLQQDLLIRIHDEQGRALQAGVFMPMAEKAGLLLPLDRLVAEQTLRLLRQRSEQSC
PISLTLCAQSLLHREFQRWLFFDLFQLPRSTNERLILQLSEAQVTRHYEALKRPLRALRM
LGCQLAIDHAGQDVVSTQYIKEFEINFLKLHPSLVREIHTRQVNQMAVRSLVGGCANTRT
RVIAVGVESGDEWKMLRHLGVHAGQGPWFAEPELLVMEPAGA
>A0A370R4Y5|diguanylate cyclase|EC 2.7.7.65|Enterobacillus tribolii|TrEMBL
MSISRQLRRFRNRLTPRHVINLCFLIVFIFTTILFWWQGNLLRQGYETNQLHQVDYVTAQ
LQGRMQYRIDNLRFLRNFMTFSLQSAPSQHQQEMIKQEIARIRHQDTWSIDPSDTEGQPV
FGVNPQRLTGVSPLFRASDDEQLTREFNALFRLRSLLPLIDVTPFRQPRVYYVSRAGFYF
SAPQPKNSDQIEKIYRHMIAQPYFTQLTQSTDPMRIPYWTHIYNDLSDGLIITASLPIDY
NNQWMGVISMDFTVEKLRQYLLGSAPSNSGGIYLLFDNRFRSITSTDPSWFRGKYFTPEQ
QQILKTRIGQKRQGTVRIGTRFITFSKMNNTNVTLIHIQTLPQGIHSEYGRLSLLLTALW
LVFAILLLAARRIILRLIDNMEGLQEKLSWRASHDAMTRMLNRAALFQKGKEMAAKERKS
QRTLAVIQMDLDHFKRVNDRYGHQIGDQTLIYAAEIIRSSVRTQDLAGRVGGEEFCILLP
ATNRSQASEIAERIRTNLANSPLKTEDGKSLRITASLGVVGSEESNSYNIEHLQLIADRR
LYRAKAGGRNRVCSEGELGELNQPQQ
>A0A2X4ZEP1|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MRRLTIWVKQLALRADFDFQTRVYSRSGLSEALKRQPIAENTLLTVMVLDIDGFKQVNDR
WGHECGDCMLAQFAQQVRQLVGEEGMVARIGGEEFAVAALTSSGQEAQLLAEKIRQGIEA
QTFTWGQSKIQLTISMGLESQPLGAARITDLFNQLLMAADDYMIQAKNAGRNRIFTQKMG
LNPTIRKYDDRFTCVKYKLKNIVMWSISRSYR
>A0A8J7WGS7|diguanylate cyclase|EC 2.7.7.65|Aestuariicoccus sp. KMU-90|TrEMBL
MRLYRILDKLFPSSFGAKVCFVVICAGILPPGIIALHLFLTGGAEALASPFLVLGAMGSG
GAVFLTIVAVQALLQALHELTHALHDMQGRRIYRPLPTRFGDEIGLAMRSANRMAEALGA
RVDPALVDSCIDPLTGVFTAEGFDTALREARGGTMLAIELDDFTGLNAADDGIAADRILV
IIGRVLREAVRKGDVVGYCTPGAFSVFLSGAGREVARHVAERIRQQVARETAPFEPPVTV
SVGLAVRNPEEEVSGLMRRAEEALDHARSGGRDRVALAGG
>A0A0M7BHI8|diguanylate cyclase|EC 2.7.7.65|Jannaschia seosinensis|TrEMBL
MSSSGPSDMEAARLSVLHHYGILDSGSEPAFDRITGLVRQIFDMPFSGISLIEADRHWFK
SRSGSCVEELPREISFCAHVIRHSEPTCVQDTLLEETFRDNPFVTGEPNVRSYLGAPLVT
AEGFPIGALCATDTKPRVFDDGQIAIMKSLAALVMDHFDLREMAGCDGLTGLLTRRAWLD
LANKEIVRAHRENGPAAVVIFDLDHFKNINDLHGHAAGDAVLTALGKMVRQEGRVEHPVG
RIGGEEFAMVIPDAGVDEAAAAAERFRVSAESLAVEFEGKRLKPTVSVGVAAFSEQFVNA
EQWLAAADVALYRAKAEGRNCVRVLDRVVPEQYPTCGAGWSVSTIGR
>A0A174F449|diguanylate cyclase|EC 2.7.7.65|Fusicatenibacter saccharivorans|TrEMBL
MQRILKSTMELTFQFEAEKHKIIIQNFNGKKENVVYTEQSLGEALLTRGLIKKKDEEILQ
DCFARCCMGELRRAAQTDALTGLWNVGGGKEHIQKILAGQKEEEINGNAMFLMDVDNFKS
VNDTMGHMVGDETLKQLAQVLKNSFEKEDVVFRLGGDEFAAFVRNMENPDEKIAQIMCRM
KHELEAAREAKKFCDTGTEKRKDTG
>A0A2H5VT94|diguanylate cyclase|EC 2.7.7.65|bacterium HR09|TrEMBL
MTLSQWSVVVQLAVASLLAIFFFTLARSLRLIEVRLWARAWLADTVALVAVYLTAFFSDS
GFLRQLTLGLYLAAKTAFVIWVVAGVSQHLAPGKVAVLGKKNAWWMVGLWGLSLGLANPS
LSAALMAQSTLVAGAFLATAFWVWRRPRFPRSRWLAASLFLEGVLFAGYVAALVPTVWGG
APPRGLLPVTSFFDAGAELVLAMSMLIVLESSSTAQLNHLHAELMDSYDRLRALVEQDPL
TGLANRRALETEPLRQHNQPVVVAFFDVDNFKEINDKYGHVVGDACLIRVATVIASRFRP
EDRVFRWGGDEFLVLAAGMDPSSVEERFAAIVQDLEKAEEGLPPCRLTMGISQLSPGQSL
NEALAAADLAMYRARQQRTASQA
>A0A0M7GSM5|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MDTGLSFSLPKWRLTRWLTHSGQDTPADIRAALIASLFGTLPIFAGGVINTLMISGVVAW
RRPEPLYISWLILEILLAVVRVTVLRSALRNAARGGSTHTDVYIVLALLWAFSVGYGVFV
TFLNHDWLAATLAGVSCGAMAGGICFRNYGAPRLVAAMIFLSLGPMCLGALFAGEYVTAI
VFIQIPFYLVSMSIASQRLRRILVSTMLAERENERRASQDALTGLANRAGLEAALERICT
SAREHDSAAALFYMDMDDFKIINDTHGHAAGDQVLKTIAQRMRAMLRVDDVAARIGGDEF
IVLATGIDATAALRLGNHLLHDASQPIVLADGTRVSVGLSIGISIISGANRKAQAVLDSA
DAALYRAKARGGRRCSVAGLPDAEDTLRPGDAAAAA
>A0A2C8F842|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio profundus|TrEMBL
MTESHTLQQALETARRRIKELEEELAKQESSNNTPLEEVAFESAPGGMAILSSEGIFLAC
NKVGADILGYTVSEMDGLPIDRLCIDEKCKTLLKTSTHVPQNINDNRISMRRKDGERIWV
DMDITPVEYGSKQAVLLSFIDITPLKELQSELNSVYSDVEQLIKERTADLENANYNLGAL
NHKLIKRDVEHQTARKSLQESEQQFRSIFENNHAVMLIIDPDSGAILDANPAAVEFYGYS
LREIKTLNIAHINTLDDEEILQEVKNAEQEKRNHFFFKHRLANGDIRDVEVFSGPITSIS
GRILYSIVHDITERREAEEKLEQYRRIIATATDLYSLVDRDYRCTMVNDSYLSTFKLKKS
DVIGKPLQQLMGQPIFDQHIKPYLERAFKGEACNTEHRVQLSGEDRFFTVTYNPVPRADG
TIDYVSIVSRDITELKEQEQNLRTFSERLAIATNAGEIGIWELNIETNEVFWDDMMRRLY
GLKASDDTPTYEVWHSFVHKDDLAKAEKALQGALKNNSQFSCDFRITRPDGEERHIKSAA
QLNDPSERPRSMTGVNWDITKTRKLQEELQRLATTDSLTCAHNRRSFMERAHSEVARSHR
HGIPLALLTLDIDHFKRVNDTYGHPAGEEVLKSLVNVCQETLRFTDVFARMGGEEFAAIL
PETQIPEAIVTAERVRKAVASTPVNTDAGIIDYTVSIGISTLRDDDDSLDDLMRRADKAL
YKAKENGRNRVETE
>A0A1V5FYW1|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MKTLPASVRLPCRPALGLILCLTACSALSQAIGQPTPQPVGNTTRPIIELETLRRQNPQA
ALQGLEALVTAPLAEPELRREAAFVAAQIASNAGLEDASVRLQAHLESASAAGEDGSTML
VKVLDAYQTAESGAPDTAWRTLAPLMGEIDRHLTETERARVALVYGYLLDSAGEIGSAIT
AYQQAVDLAEANQMSALATRARLQLAWAVTQYGQNARGETLVRQALQDAEKQQDMAAVIV
AYTSLGMVMEQRGDLEGFLAMMTLAIDRAKQSGILDDLPVLLGNVAHYYLSIKDFGAAEV
AASEALQYSEQRNDDDGIALGKVNLGLARIGLGLLMEGRALVREGIAMDARRGLINDVAA
GLQDLGNALEAAGDAKGAVEALHESRRLSDQIYRDDQRRAVLELQEKLDAERRERELVLL
NAESALKTAELKRQSVQRRLWWLLGGVFALVLGLALLGLQRLRRDNSSLLGRNQQLRLQS
ERDALTGLANRRQIKPYLQMTAAEHGFSGAVLMIDVDHFKRINDVFGHAVGDKALQEIAR
RLRTFCREADLAVRMGGEEFLLLIDQIGDDAVPKLVARLLRRLAEPYDIDAHTLALSASI
GFARSPLQGAGDLSIDVLLKWVDGALYLAKSEGRQRAVGIQRVIHKEGLDTDRVAQDLLA
AVARDELVLMRVDAYGTEVST
>A0A8F7MZT4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas amygdali|TrEMBL
MTSSSQRLALLEAVVEQSFNAVLITDANLTNGGPFIVYVNPAFCAMTGYAAEALIGRSPR
ILQGPDTDRQVIERMRQCLSESLFFEGSTVNYRADGSPYVVEWKISPVRDEAGAVCNFVS
VQQNISPRIRAEREQHLLAQALNAALDPIMITDCNATIVFANEAFQHITGYSAPEIIGEN
PRVLSSGKHDEMFYAQFNEALASGTPFRTTFINKRKDGSLFYAEHSISPLCNLEGTITHY
VSISQDVTTRLGREQKLLEIAHSDPLTGLNNRRAAEHTLERLIDTARISGRPFSLIIGDI
DHFKSINDRYGHPAGDRVLTSVAVILKQRIRLQDVAARWGGEEFLILVPDSSLNHAAELA
DRIRKGVESLLIPDTGSVTISLGVAQLSPGETAASLIQRADKALYQAKRLGRNRVDIAQA
DDAIY
>A0A376H545|diguanylate cyclase|EC 2.7.7.65|Enterococcus gallinarum|TrEMBL
MDIILWIYYTVVRLIVVLGVVFLDYLIYLSMKESIFLKTKAVLRKVAWIGIMIISLAILQ
GVPVLSENLLQDRYTTLIQNMDLQLIVLFYFLHMLKGTMMLHFNVFVSVAITFYYMCQGE
YQTIQNYFIAIITIVLIYTCCRIVLQLKDKNLNNIGVYFLLTLFYGASWGLKMYPALDFR
FAGYLFFLLNFVMLMIMVRMINKLVRRQLTKFDNLSLEARTDFLTGIGNRLSFDREFSQR
FELSHTKENLVFAMVDIDYFKRINDDYGHDIGDIIIKNVAKIISQTLFQYQLESQVFRIG
GEEFGILFQEKSQHDITEILETISKRVGNFSLNIHGEEVRVTISAGVSRCRKTDTDKEDL
YKRADKYLYIAKREGRNAIFMEGKIKHIS
>A0A075R6A4|diguanylate cyclase|EC 2.7.7.65|Brevibacillus laterosporus LMG 15441|TrEMBL
MRTRTQIGTVGKLFDSVVPFFLPSWPIQAPGLLFFATPERGVIATYELGTLPAHLPPTFF
QDAMEELVKQEVTKAWKNGQVISKERVTSECGDYKWLLQALGPQPDDIHAIAGILTCAQE
ALVNIRTYGEMVKGLYSLGYKGFIQRMASEIVVEASKCKEATPFMKTVVNGLHGMVGRGH
CSLIKLDESGHLLPQERYTTDSAVYAGSKIHQVLHCFVSKKAEIYQEDSRVAMYPIYVED
EPIAALILHVADQEQQCLDKLDIELLHSTGEQVSHQLHRTLHMHDILRETQKKELLYQLT
KQIHASIDVNDVLAGVLASIKQLYPYFSAELYLTMEMETNLPIKTFSLKKQHNQVSQQAY
LEGKLMLGQEIIDGQAITFVAAPLHGRQGIYGILQLATHEIINLSAKETEFISILAETAG
NAFENAQLYQQSRDMVRELRLINEMAQQINRSLNMIDILEFVIKMLHRTFDASYSAILQK
ASDGERMQIISSSKNDQIGQFVPISATPIAEIIIDKRKILPSSDSFTHLPHHLFPYHSVM
GVPLLQDSEVSGLLLVADHKPNFFTYDDYKLLELFGQHTSLAITNALLLSEVERMVITDN
LTGLFTRRYLNENVKKSLLADEQGSLILIDIDYFKRINDTYGHLVGDEILYQVASVIKNC
IRDSDIPARWGGEEIAIYLPHVDVLIASKIAERIRIRVQQESKPSVTISCGVAMWSRDVQ
RNRSAEELFHDADVALYKAKQEGRNQVRKSESSKIW
>A0A1C7D863|diguanylate cyclase|EC 2.7.7.65|Paraurantiacibacter namhicola|TrEMBL
MSLTAAPGAGAVGCAVSRIAHAIARIREWHRPILAALVLCVIVIAVRPAEQVDSRFSDQL
LASQAVQPDADLAIVEITAEDTRRFGGQPVPRAAMAALVNGLADAGVDRAYLDFNLGEAI
SAGPDEALANALARFDKDRIALASGVTPEHLPAPVFQKHATVLDSRIAQAPDGWYRAVGQ
SGGARGANPSAWLANGSTTPQAAGLDLRVAHWQFPRASMSDVIDGKADLKGKTVVVTFSR
SFAPTRTFLPIAGESDRAAVFLLGAQSQRNGYDTVLQRGERANIALQLFAILIGFVTGLV
ASSGRKLLLLMGAIMFFVLATNASIAASIGAPAQPSTALFCFLVMVNVTLVQRLRIVPMI
ANFLKGDLSPDEALAWRALEPQERPAMLFGANGQIKRMNAAARDRTDLPHGEIAQACFPR
MGERGQSIALQLADGSPASFALDWPYPNVPVVVLEDRTATDAMTRQLQRQLEVDEMTGCL
NRRGFDNALSAARNTGRNYAVFFIDMNGFKAINDTYGHDAGDELLVATAARLQALSRSDD
HCARLGGDEFAMIVMGTVDADTAQRLRSRIEQEIAVPVKLRASAATVMPSAAVGFAMSSF
AGEDPAAVLRRADQDMYQQKGQGRAAPRAA
>A0A1L8CMY9|diguanylate cyclase|EC 2.7.7.65|Mariprofundus micogutta|TrEMBL
MNTTHPAKDLQVLAESLASVAKVTKNLDVLIFGAGLGGLAMLEVLSQSEHVSIHSIIDIS
EDAPAFQLAHELGVNTSTDSSAELESFRGDIIIDVTGDASLRSKLIAFKREHQVELISAK
SAKLLFDMANQELRSERTIETQNSRLSLLDCMLEITLQLESRPPIHDITSRSFADIHSHV
HAISGLALIFDKQSKAPQCVGAIGENAPDCSEIESCQSCNGIILDACSRLSQKERYKLFK
PSIQIKCQAIENCYNVALPLWQDTRLSGVLLFDIQAPLSKEQKTTLKMASVHLNMTFKTL
DHFQQLEEMAIFDALTGVFNRRKFDMQLHQEVSRIKRMKNGTLTCGFIDLDDFKQINDTY
GHQTGDLVLKHIATSIESCIRDYDLCARYGGDEFVILLPSDDAMQGSCLERIGMRILEKV
ANFDLVNAPEIKTSVSIGLVTQSGETAHAETLLKKADEALYEAKKSGKGCLRIFADEQFH
YTPSKE
>A0A1E3GNZ4|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MGFVDKLFDGSFMPHGHCLRWLPDLLFLHVTGDVLTAIAYFVIPLALIYLVKKRTDLGFN
WIFIMFAAFIFLCGVTHLTSLINIWQGFYYIEGIAKFTTGLVSIFTAIMIWRLMPKALAI
PSNEEFRSKNEALLRVQHELLEANQSLELRVLDRTKELERIAHTDSLTGITNRRGLMDSL
TVEIDRAERYQHKLSLLMVDLDHFKYVNDEYGHLTGDAVLIESANILSQACRSTDVLGRY
GGEEFLLLLPETDTESARLLAERIRVDFEQHRFCQDDGVEISLTCSIGVAEFQADQSQTS
LLQTVDRMLYSAKNAGRNKVVVNGYSETYPS
>A0A752DLF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPIFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1E3GR78|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MVRANGEKFWCAVSGQVINPENPTEGSIWLYEDVTHQRQNEERLTRLASSDILTGLPNRG
VFKDRLEHAIHKAQRQNGRLAVFFLDLDHFKHINDSLGHKAGDILLCEVARRIRSCVRDS
DTVARLGGDEFTVMLEDIHSAQYVGKVAEKILSTTLCRICWITLK
>A0A2C8F806|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio profundus|TrEMBL
MVKRDNTTVDHFDTIGILYKGSGSEDSVHTYSYAESSNDGSSLSFRSSMCHNGAIHGTVK
PKGPMPARFKSLPLHPMPKRRGAGFPDLLSSAREKRTFSVPVPVADGTYRAFNLNTLRSS
NGDMDTNIQEHLNNDIIHVQDDDIVENDLMDIVAQNDKVIIVHNADGPIGWTTVHESLLN
STAAPLTRAKDYLIDNRHVVLSLTRSVYGAHKELFSQQRSVVLVIDDQGELLGTITDRDI
SRLIEKGCDIWNTELANEVKPSHVLTENKPISLNDLDMVASYAERPVPIISSAGSLMGIA
DIKKMRRYLNSAAEITQENSTEAAPMNPISLSESMILDAVLSDTLRTGIVGTDEFLNIIY
FNEAILDFIQKPELLRLGSKIWAVTDSCAISQQSLNAMLDTVKEDGEQIFANWITINEGK
RYIQCRLSTVKQRAHTAGFVLSVQDITAQRNAEEAIRKLAYQDRLTQLPNRLLFEERLSL
EAKRSERNGSQFAIMMLDLDGFKAVNDDYGHSAGDQLLQIMGERLLNSIRGSDTVARFGG
DEFVFILPDVSNPQDVETIAEKIQDIIHKPCEINGTVFHVGASIGYSIYPDDAEDPKALL
DLADTRMYKNKRENC
>A0A2S8DSQ2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATRGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A2X2J357|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTI
FKREIAHANLTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFR
YGGDEFIIVLTEASENETLRTAERIRSRAEKTKLKAANGEDIALSLSIGAAMFNGHPDYE
RLIQIADEALYIAKRRGRNRVELWKASL
>A0A1S9JIR4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWISLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8E2P0K5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLTGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A140L9U5|diguanylate cyclase|EC 2.7.7.65|Fervidicola ferrireducens|TrEMBL
MKNLKSFVMEYKNYLSEYLLKGGQDEVLFEAYQRLIKLLDESSAQAANILDIHNQVLKEV
LNIKQDNDVVQWIYIERATEFLAQILIATDALLLTLKESVERDPLTGLYNRLAIDRILSK
LWSNASMTKTPLTVAMLDIDNFKDINDRYGHVIGDELLKEVSTVIKACLRDKDVVMRYGG
EEFLILLPETESSGAKKPLERVRKRIEEGVFTEARIKITASIGAAVYPDDRPLSMEEIIE
FADAAMYAAKAKGKNRLVFYSHLNGKN
>A0A7U6Y445|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MDSSRYLVVEDSKFFNSIVSKAVGERVGAEVVSTLSLAEAIKAVTESELRFSLAVVDLVL
PDAPNGEAVSWLQDQGIPCIVFTGVFSEDLRERLLAEHVLDYVVKETPSSLSYLVDLVGR
LHRNRNIKVLVVDDSRTARGYAADLLKSYQFQVFEAESGEAGLGFLADNPDIRLVITDYN
MPGMDGVEMVKRMRATHDQDRLAIIGVSSGGGNALSARFIKFGANDFINKPYLREEFFCR
VMQNIRMLDMVERLTDMATKDALTGIHNRRFFFEAGETLFARAKRDQVALTAAMLDIDFF
KKVNDTYGHDGGDAILKRVASLLRSLCRQTDVVARFGGEEFAILAVSMDDCALHPFFEKL
RASLEAEEIIHAGHRIPVTASFGVCHGIGTSLESMLKTADEMLYQAKQNGRNRVEVA
>A0A8G1L4C0|diguanylate cyclase|EC 2.7.7.65|Qipengyuania gelatinilytica|TrEMBL
MLAREHPDAVRASKGGTARAAAMDAEYEVQREAILAMLERERRSLTASLFGLAILLCAIA
LMGMPQLHVIAICLRACSFLFTRWAATDLERVYRERGDTVWPRRILFIAMCLTGATLGLM
ALPPPETALVASGLMIYAAVLMILTLIAVTLAALPGPRDGMLASFLLTLAVLAFFYPDGQ
NPTILAIGAMAVIGIRVYSANTGHHIIASAEILVENRELSDELSEALAHAEFLSWRDPLT
GLFNRRKLFEEREHDPQNGSARHVLAIDLDHFKGINDRHGHATGDRVLVASADVIRARLR
AFGADHLPAFRHGGEEFIVILDGCDCAEARRFAEALREDIASIDVGIDGAGRETVTASIG
LARWHPDETLDDVLQRSDLACYQAKGEGRNRVSAVA
>A0A8B4T4T7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERVEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1V5U5U2|diguanylate cyclase|EC 2.7.7.65|Candidatus Dependentiae bacterium ADurb.Bin246|TrEMBL
MLLSFTKVVNMEKKLVNFIKYAPMIFIPLVVFLVFYLIITGYKSTLNSNFEIYKKDLIDK
QKSLVKTNIQIATQIFENQVFLTENKEKAYKSFLNLIKNINNTASDYYFIFNTKGDVIVH
SFLSHLEGQNLYIVDNENYNNVVKIITQNSSADRFVTYKWLNPSTNLIEDKISFVRQLPN
SDLVIGSGFYLEDINKIVENQRDIELKEHDKNINVTLSLAIFFTILSFIISYIISKMLLN
AFNILNKSLKEKSIELQKLNSELEIKVENRTNKLKTAYKKMKDLASIDDLTKIYNRYYFF
NIFNQQLEKLKSDKTIFSLIMFDLDHFKNVNDTYGHDVGDYVLNETCRVVEKDLRENDTF
ARIGGEEFLILLPNTNIEDAFYIAQRIRQNIEQHKFKDIPKLTISLGVAEANEPILSTEL
LKKVDLALYKAKKEGRNRVIAFKN
>G0ET32|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MGQPRRVDRGPSGRPRDTAHQQDPMRQAGVSLPASGHVLRIIWPFVPVVVALALFSIASL
DLLSAARAFVAGESQWSKGQKNAVLHLLRYGEDRDPADFEAYLESIAIPLGDHHARLELD
RDEPDLGRIHEGLLAGGNHPEDIPRMVRLYRNFRHIQEVDAAIRVWAAGDIEIAALHEQA
LTLRRLIRQPGCRDDCVAPVLRNIAQIDARLTPLEQAFSGHLGQASRRVTRLLTTGSAVM
AAALLMSAILLSVAPLRRERRLREALAQREEQLQLAVEGSNDGLWDWHLGRGELYFSPRC
AQMLGYHDDELPHARETVLGLLHPSDLAAFEAKLAHHLRSGEPYDAEFRLRNRAGDYLWV
RARGRLVRGAGRRRARMAGSLTNISDHKRYETQLFAEKERAQVTLQAIGDAVVTADVWGR
VESLNPAAEALTGWREADARGLPLSNVCVLRDEDSLAPLPDIVTLALRQRWRSRSAQLVR
RDVSGLPGQALAVKPSVALIRDRAAQAIGVVVVLHDISQERAHAARLAYEASHDALTGLV
NRAEFERRLGAAITRSREQGTTHTLMYLDLDQFKVVNDTCGHAAGDELIRQMAEVMRSQL
CRSDTLARLGGDEFGVLLEHCGTGDGERVAEALRHAIACFRFAHRQRTFTLGVSIGLVTL
DRQTVNVAEALSAADAACYVAKEGGRNRVQVYHPLDSVVQARHGEMEWVSRVHAALGAGR
FCLYSQEIVPAHDGALPQTGRHVELLLRMVDERGRLVPPMAFVPACERYNLMPMIDRWVV
ETAFATLAGRQAEIATCAINLSGSSLADIQFPDFVREQAQRFGIALDGICFEITETAAIS
NLAQAGAFILQLQQLGCKFALDDFGAGMSSFTYLKHLPAAYLKIDGSFVRDMLADPVNLV
MVEVIQRIGHAMGKQTIAEFVESEAMLERLRELGVDLVQGYHIAAPVPFAPADAEAGDRP
ALALAG
>A0A8G2IGL8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISITLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A3D1BZQ3|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEKIHTECSAIM
QDADERMYEIKKGKR
>A0A2X3EYY2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAW
HDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHINDRYGHQAGTGCCRWW
PVRCPARFGRAICWAEWAEKSFVS
>A0A486UG67|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVVLAQLVLWDKRRADS
MPGPINALNLFCFCLFAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGISEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASCVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVDEQGMVARIGGEEFAVAAVVDSTQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISMGLETREVGHARITELFNQLLMAADEEMVKAKQTGRNRICMPALTESAP
>A0A1V5QX99|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MRYAGLSFLRETAVQSETRLVGLEPDWRPTRSRELRIPALPPGTYRFEVRSRIGDGPWGS
TAGFGFVITPAWWQTWWFRTLAGLALAGLGFLAFWLRLRSLHHRTVLLESQVAERTRELQ
AANEALRTQSLTDPLTGLRNRRFLGVCMPEDVAQVNRTHRNISLGKCERNGLNIDLVFLM
VDVDHFKMVNDQYGHPAGDAVLQQLAEILRSATRDSDTVVRWGGEEFLVVARNACRKDCN
VLAERIRSLVEAHEFRLEDGQVLHRTCSVGFAFYPLVEMPPDHVPWEQVVDVADHALYAA
KRGGRNAWVGIFPQEGLGAEDLPRNPGHDLPPLIATGKLEVVTSLPSHVPLDWEPSRD
>A0A378H2D2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDYFTHHPTITIFKPIITPEGKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKV
VLHSDPGALFKPFVRDELMDKMTSGEGQLYEPGSDTWYYYYSFTNPDWFVIFRVDNATLV
NLTRHETNLVIGGFTLAAIIIILFGLYLRHASRSVLMNIINAIKTGDVKRAPRLEAMLSK
AIETNKQRELSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDT
WGHLNGDIVLRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVE
RRTWREDGLTVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A2X3CBV5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAGRLGGDEFA
ALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAEMIGKCDEV
MYLKKKRKTLSRKTEP
>A0A486RPH7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MEKPLRLKLKKLYHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLSQRHQETWRVALPNRRTL
PVFGVSEGVVRDHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTYYSRAISALWFTRQTQRNNPHRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMQGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMAVASDCQR
SGRPLAVIQLDLDHFKGINDRYGHQAGDRVLSMVASTLAGTVRDGDLLGRVGGEEFCVVL
PNTTLQEAAAVAERLRLRIHGREVFLHNNVTLRVSASLGVSGSEERGEYHFEALQSVADG
RLYLAKQNGRNQVWYRSEA
>A0A5E4TDK5|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MTTQRPPSPPMRPGASSVTGLLPVDGLADASAESEREPPLASPHLAASAAVRHRRPSLQR
VLRRTHLRLAVSAVVLAAVSLSLVAWIALRVYAENNLLLIGRSLAYTTEAAVVFGDRVAA
QEAIALIASDEDLAQVRVLDAGGAQFALWRRPDGGALTQVERAVASFALPGPVTLPIRHD
GRLVGSIEVQGQGHQFFLFLLTGVGGVLACLLVTFAVANVLAKRMHHDIVKPLRALAEVA
HAVRRERAFHQRVAATPLAELKELGDDFNALLDEFEGWQNHLRAQNATLAHQANHDRLTG
LPNRAYFESRLAKALADAREMGTHVALLYLDSDRFKEINDHLGHGAGDAVLVSIAERLRQ
PLREGDLVARLGGDEFAVMLVGVRQTSNAVRLAQTLLAAMEKPIALPDGAEIVTSMSIGV
ALYPIHAADAVALLRTADAAMYQAKRAGVGTWHVADIPTGAAAARRSS
>A0A378BF27|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MENDAWALSDLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDG
LRIADELQDEQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVA
IDQATERSRIWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVE
TPHFTQVDEIGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDV
IKVAERFAPNIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHP
PVQGEPDITCYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALG
LALANQRLRSALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKT
INDRYGHEAGDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYT
QVRNMTLRDGLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFVRL
KTS
>A0A377V690|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQNRRLQYDAYHDSLTGMPNRLSFWQRLQEIVNQVRPYKGCAVVMLFDLDSFKDVNDTLG
HDAGDKLLQDLASRLSFFRKTSETLYRLGGDEFAMLSYDLTEEMALERANVIRGEDQPAL
SDLRCAD
>A0A3A3EQ03|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas profundi|TrEMBL
MHQNTGQGISSLSNTQLEDVIAEIEQAIEWHQSWYKNLLRCLIADTPVNEQDLADNAHNL
CRFGQWFNKLPEQTLNLHPYFSEIACAHKKMHQGATVLLSLKETKSAISVNLLDQFHADL
DRLRELFDTLIDEFSELLHTRDPLTGASNRTNLVENLQKEHELCKRKSLSCALIMIDLDH
FKQVNDEFGHAVGDKVLIALVKCIKSHLREYDQLYRYGGEEFLVCLPQTELEGAKSFSER
LRAGVAALKIEIGNDQHINVTGSFGVALIDVDDDIETAIERADQAMYQAKKSGRNRVSVA
>A0A8J8BFM2|diguanylate cyclase|EC 2.7.7.65|Desulfovermiculus sp|TrEMBL
MTSLQKEYMTKVEAPFADSLTGLFNHGFFSCALDLEFRRYKRYGTALTLVFLDVDGMGDI
NNRQGWMTGDKVIKRVGECLGCVLRDADIAARYSEDCFALMLPQTSGAEGASPVERVCSE
VESWSQGTVTVSAGIACVQDEDTEVEALINRATNALHQAKLNGRNRCILAESSPRSRPSS
LPTVLVVDDEEMNANLMQDMLNTGEFQVQCVHRGQDALTAVSQMDIDLMLLDIVMPGMDG
YEVCQRLKNHDRTRQIPVIMITGLEDRQAKIKAIEAGADDFITKPPDSMELLARVRSLIR
VKTLNHNLTSIENVLFSFARAVESKDEYTKGHISRVASLGERLGRHLQLPSSELRALRIG
GALHDLGKLGIHENILNKTGQLDDCEWHKIQQHPITGAEIAKPLKDTLGASLDIIRHHHE
KLDGSGYPDGLKAEYISLPARIMAVVDIYDALVTDRAYRKAFSPEKAVAILEQEAQAGKL
DPAVVEAFTVMMQDQRS
>M1WKS6|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio piezophilus (strain DSM 21447 / JCM 15486 / C1TLV30)|TrEMBL
MGSFRLCQCERMPASTELKCIIKRLQESPEACVGLMAGGRLKGIVTIETLIANLDSHSGR
LEGSSALECASTSFVMTSGDVFFTDFLYENSSKSYDNIILTSSHGQISLVAKDTFRQILT
FKNRRIREVLPVTSGVPALNEKESCLKALELLSHEEHPHVVSLGNDGPTGVVTRHDISRA
IEMRQNLWDIRLVDVAQSNVTVLREDISAEEALFQLEGNPNRLIICEDSDGGVRSVVDIM
QLRRALIGLLKPKKYEIAYQGVAQRQLSDILIERVMSDTMGIGVVALTPDLEIQYSNRTA
KKLLGLSSVSLSRKSAYSLSHDIPLLENVVHAVGMLDPVSNPVVDLSNRTDFPSNYQTKL
TGVWKNNDPSGFIVTIQNSTDVRLAEAKLRKLAYYDALTGLPNRTLLFERLNMEIRKSRR
YNEEFAVVFVDLNGFKGINDRYGHRYGDQLLIKVANRFSNVLRETDTVARLGGDEFLFIL
PGASFMETAWVVSKKILAVLDEPIVLEEVTVSIDASFGTAYFPENGLTPEELIDFADQEM
YESKRLGL
>A0A087D1B9|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. saeculare DSM 6531 = LMG 14934|TrEMBL
MSKTIEASIVVVDDEPSIRELLVASLHFAGFEVQTAASGSEAIEVIEKAQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVSRAGQSIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIMVTDENGEQHKVAPLIETKRGIGYMIRA
PKTAQGA
>A0A087CZQ6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium pullorum subsp. saeculare DSM 6531 = LMG 14934|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSSAATGEEGLELFTKGGIDLVLLDLMLPGIDG
IALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
LSGEGSGAADDDVPLVCGDISMLVGQHQVTVRGENVFFPLKEFELLEYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRVRAKIEEDPAHPRYLTTVRGLGYKIADPE
>A0A517VNH2|diguanylate cyclase|EC 2.7.7.65|Gimesia algae|TrEMBL
MRNYYTAIQFWSYALLVVCLCPLAVFLGSYMGWPRGAAPLLLLAPPTVLAAVSSPRICYW
TITALSVGSCFAETYFRTDIVKGDNNYALSILSAAVLIGLVLLIDVYIGKLKRTLYQIQQ
QNDELVRQLYESQKESFANLQNTGDADETKPRQPAESRDTPAGEVGVNYPLLLLTLQDIG
RRISTNQSNESLIPTVISTAKASLQCEYCQVYLWDSKSRSLKNALPVRARDQLNYRPVPE
SGVAAWVIEHRQIVMRNDAEQDYRLKRILDDDPHMPDAISPLTVGSDLIGLLVIDKVDVE
SPTIGRLLYILSNIYALGIKNSQLFKRIEEMASRDGLTGLFNHATFQEKLHELVTQADAQ
SSQLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPEKAIIARYGGEEFIGVLL
DHEYSQAMQIAEDLRETMENCPILFEGQQLQVTASFGVTEFKHPATTTNELVRIADENLY
KAKEGGRNQVIGLDPNSARKPRI
>A0A1V5JBQ5|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MITSIVYHGKRAALGSFMDITARKHMEEALRQSEERYRTVIEDIEEGYYEVDLQGNFTFA
SDSICATLGYTREELIGMSYKNYVPNEQFDYVYNIFKKVYETGKPIKSYSLINIRKNGER
IHVEDSVAPLSDKDGKIIGFKGITRDITQRKIMEEILQKSEDYFREITENSSDVIIITES
NGNIKYCSRSVERYLGYKPEELTGKNAFNFIYADDLPRAANDYSKAIQTKDTAIPNEFRV
VHKDGSVRLFEGLGKNLLDNPSVAGFIMNIRDVTERKQLEIQKEAAQKSLRESEEKYRTI
LEKMEEGLFELDLKGNITFVNDAECRKLGYSREELTGMNYRQFQDENTAKKTRQIFSEVY
KKEEPIQLLDVEIIRKNGSKAFNEISVSLLKDKQGKATGFRGISRDVTVRRQMEEMIRQS
EEKYRTIINEVDEWYFEIDLAGNVIFVNDAIVRSVGYPPERLIGLNYKSFTSKERSGEVF
KIFRQVYETREPTKNFPYEFVLTDGKITFFELSVFPKLDDQGKVVGFRGVGHDVTERKRT
EEQLNYIATHDLLTGLPNRMLLMDRLKMATAQAKRNAQKLALMMLDLDNFKNVNDSLGHM
VGDKLLKEISLRLTGRLRQNDTICRLGGDEFIILLPAIERVEDAVEVAKIILESFEQSFI
CNDHLINSSISIGIAIYPDDAQDIDVLMKNADMAMYYVKAHGRNGYHLFSYANNRQFSQT
IQ
>A0A6B8N3T1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MISELDLAIQLTKIIILLYISYLLLRHQVSNKILYGCLLAMISMIIELFINYCQLSWPAI
SSDHKDEVLLISSTTLLIAHILMLSGVSSLYFKLKEESEKDHLTQLNNRKFMRKIPEKDY
DVIYLDIDNFKSINDTLGHDYGDALLVLFARYLSHCILKNEYLVRYGGDEFIAYVQPGRS
GDFIERLLGYVANSEIEFSYGISGSAKGELFSAITRADKNMYLMKRRRSTSRGRKPAQVN
ET
>A0A514VG44|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNRKFKEIDETVRGLNQSTDAHFKWLVKLLRFIDSRNVDLPEVSSEEAHLHCEFGHWLNT
RLLEEREDTNFLLDINKKHIHVHQACRRLISAIEQQRQRNEDFDLFEQSLLAFTDALTLY
KVHLLQLRTSYDALTGLPLRRILDESFGSMNKELGASGLYLLLLDIDHFKKVNDNYGHLN
GDIVLRSLALNISNNIRRSESMYRYGGEEFIVLLHATHDDEAVIIAERLRRDIARLETIA
GEHIIRITFTGGLTRIHQGEVLREVLERADIALYTGKKSGRNCTQLINRELETQKFCD
>A0A4U8VD02|diguanylate cyclase|EC 2.7.7.65|Burkholderiaceae bacterium PBA|TrEMBL
MKNSPSEQMVRDWAAVVAQYAPSTRARVRALAQQHQHALASRFYDSLLSDAAASQLVSHE
QVQVRLHASMMRWITDVFADPEDIAPQALVERQIRIGEVHARIDVPVHLVLRGARSLKQG
FYALLGAEDESRNDGAAVQLVTQTIDLAMEIMSQTYAHSHERSARADEAYRLLSMVQNAS
MERERQRAALLDWESAVMYEIAVGEAARLPRMAASEFGLWFRHKGVHAFQGTSEAEAILA
AIAHVDEVVQPALEAAQDVEERQRQARELRDHARRMALDLDTLFQKANELEGGRDVLTSL
LNRKFLPVVLSKEVAYARERNSQFAVIAIDIDHFKQVNDVHGHEAGDMVLQQFAALLSDS
VRGGDYLFRLGGEEFLMLSVDVDEARAVAAAERLRARIAAEVFRLPRDRTMTLTISIGLA
MHDGHPDYQRALRRADVALYAAKQRGRNCLVVADQVADKVTAG
>A0A8G2A7T6|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MEKTFWNDLKHMARHSRKLSFTMPILIGFTGILLSFLLIAVFVTTTQRQNFLEDYHHVNR
NFTHNLAVNYTESLLRGNDYILARATKFFAKNDKLNQAINIDPQSGLQELMQLQELMPTV
SSISLADTQGHYLRAPEVLENDNSRAFDPKSRPWFIKQAEASTFSHYTSPYLDFFTQHPT
ITLYKPVISPEGRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDTGAL
FKPYVRDDLMDKMTSAEGQLYDEKNGIWYYYYSFTNPDWFVIYRVDNTTLVDLTRYETDI
VLWGFALAAIVIILFGLYLRHASHTVLMNIINAIKTGDVNRAPRLEAMLSKAIESNKQRE
LIYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIV
LRNVAREGLQIFQPLQISLYRYGGEEFAVIFTGEHITNAPAILESWRLNIAQRTWREEGL
TVTFSAGLGEWNMEPLEQLVVSVDEALYKAKQQGKNRIVRA
>A0A485CGQ9|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MIMLSHPLRSPDGHYLGYLGGSIYLKKQSMLSDIISLHFYKDNVSVTIVDRDGKVIFNTA
PTMTRSPVNLTPQLKTYMSNNLNGSFAGRDYLVGYAGLKKSNWNIIVSTPSEVVTSMLFN
TVKKISGLVLAILFFITTGVAFLSSRIAKPLEQLARLVQTNDSLTSPEKLSSIRAWYQEA
YLLREAMEKRFRLVSAQFAALSDEAMTDPLTGLYNRRGFYEQLTYIKNLKNQCAIAVDID
HFKAINDRFGHSTGG
>A0A080LU37|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-91|TrEMBL
MSKGEGWRVASDLAGAGGKILAGGFSQRLCRRLTECVAALATLEKISSPIVPYISAWHEH
EKILWYEYVGAGFLALLGCERREVDEVFRQSIVDRRLYRYAERESRVEEEIVTRAELQGD
QAGLREEVKKAGVVEFVYQLALPVGKRIWLKDQANIEIFVEDQICLSIGCLTEVTKEMEQ
KDLLEKIGYFDELTKLPKRTILQRIIEMNIGNLRRGHINDFVFLLLDLDHFKGVNDTYGH
QAGDQVLLGFAEVMRATKRHEDEIGRYGGEEFYGFSIGDLKNGLQFAERLRLAVANTDFI
FNRERIPVTVSVGLVAASQLAGTGEISVEELVRVADRRLYVAKEEGRNRVVYQG
>A0A7G6V6E4|diguanylate cyclase|EC 2.7.7.65|Burkholderia cenocepacia|TrEMBL
MTRAAPPIRTSRPTRPTLQSVLRRAHLRLVFVAVTMAAVSLIVVAVIALRAYAGNNLNLL
ARSLGYTVEAALVFGDRVAANEAIGMIAGDEDVAQVVVTDSKGQLFATWQLPAGNGLARL
ERAVADVALPGPVTVPVMHDGIIVGHVVVRGRGHQFFGFLLGGVGGILGCLAVSVFGAYV
SSKRLLRDIVSPLRALAGVAHAVRRERAFARRVEPAAIAELNQLGDDFNALLDEFEDWQN
TLRDENASLEHKATHDALTGLPNRVQFESRLALALCEATLTGQRVAVLYLDCDRFKEIND
GFGHDTGDAVLIDIASRLRTRVRETDLVARLGGDEFAVMLAAVPEAGSVCRIADEILSGM
APSIELSDGRVVATMMSAGVALYPDHALDASGLLRAADIAMYRAKRARPGSWQLAESVAG
PV
>A0A6N0HS49|diguanylate cyclase|EC 2.7.7.65|Candidatus Reidiella endopervernicosa|TrEMBL
MIPLVQPTSSGLLQALEDLDKGIVSHTNWLKMLHRALICDDEKADEKDIQPNAHCNCNFG
QWYYSGKHPELDEMEIFAEIGRQHQAMHDNAREILLKSDREEPIVFEDYDSFISLAIDFK
LEIRKLQQQIIDQVCVVDHLTGAWNRQSMTSRLTQEYERVVRSGNSCSICMLDIDHFKQV
NDTHGHAGGDQVLKGIIDRCVKELRAYDSIFRYGGEEFLLCLPDINPAAAHPLIERLRIT
IEESPFELNNGNSVKVTASFGIAHITPEKTLEDVIVEADHALLYAKSQGRNCICTWNT
>A0A7G6V4V3|diguanylate cyclase|EC 2.7.7.65|Burkholderia cenocepacia|TrEMBL
MIRLGLTSKLSLLFACIGVIAAGTTGYSAYRANRAMLVQEAQHSLLMSTQLLGQRFTTAL
ADVADDALVLAQLPSSASVAGGDNPDTARRMRLEQVYYSFMRNHAEYLQIRLIASGHFGI
ERIRLDRDARGIVVLPESAFQEKGQFSYVFDTLATAPGHIYLSPIVVNHETGSHAAEGLP
ILRVGTPVVDAAGQTVGALVVDVELSRVLDRLERDLPDDYAVYLANEWGDFLVHPDPAQT
FGFDRGRRVLMQDRFAVTRALFDSARTNVTLNGLAQPDEAPGQMFAFVRTPFGQDEGNRF
VVLGMARPLADVLAPAGMLGERIVRMVLVSSVLAVILAILFARAITRPLQTLARAATHVF
DDPAAERLPVARADEIGVLARCFDSMRVEIRTQMAMLRAKQLELTHLAGHDPLTGLPNRL
LFMEHLEAAIRHAAAVREGLAVMFVDLDRFKQINDQHGHSAGDRTLVAVAKRLSQVLRAG
DMAARLGGDEFIVLISDVSSPAVIGDVASRIQIVMAEELEFDEGRMAVGASIGVSEFPAD
GASAEELLVKADAAMYAAKASAQCVCVRYQDLVRGGTPDQTGRVASDGTR
>A0A655WAG8|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMXXXXXXXXXXXXXKSM
YAAKIIRRYLTACSDFHSALSSVRLSPPLTFASCTTLHRLVLLQTHLNSLVLQVGGK
>A0A8G0FVK5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDARLFDNTQTLRASVLCGLSFFWALIAFLMALINFWPTGLVELALLELVCAFYSLYIYS
LAKRRIHTEQHIYFYLFVLTGTTLFATYMKPLMMGVYIWSCFVPILFYIFTSARFAFVTS
CLFLIMQSNIIYWQLQQTGAAISWSVLLHLCFAYIGIWVVAHVYEDNRRKIENSLLYLAS
RDPLTGAHNRLSLTTSFQHFERFSDQTSLCLLVIDLDFFKSINDQFGHDTGDKVLIETTR
LFTQVVGDNNLYRIGGEEFCVTLFDQSLEQAGRVCERLRAIVSQHLFAFGEKRVKVTISI
GVCEYQAGDQLNDLLKFADMELYRAKKAGRNQVRLFRHASTNPTVVNQQTENV
>A0A8E6RQH0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Shamba|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A655U4E6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIDIDCFKEYNDGYGHIQGDDVLRKVSQTLRQWKSNLDLCFRYGGDEFLIFMTRVDAKQC
QQRAEKLMAMIHELNIPHLSSRVADHVTITVGIRHCDQIEKEMTAEKLVLVADKALFHAK
HEQRGTIHMFSSTTWHE
>A0A808FJC5|diguanylate cyclase|EC 2.7.7.65|Xanthomonas citri pv. phaseoli var. fuscans|TrEMBL
MSPGTLHRNSESAVLPQRVLLVENSRTFTSMLREAIEQRVELPVTVVSTLAEAARVLDEE
DGWFLVLTGLVLVDGDRDKVVEFFLSRKLPTVVVSGVYDEDLRQRVLQQQIIDYVLKNAP
GSIEYLAWLVQRLERNRRIAALVVDDSLSARTYAGALLSMYGYRVVLAADGAAGLDAIER
DPDIRLTIVDQEMPGMDGVEFTRRLRAIRSRDKVAVIGISGNSDSSLIPRFLKNGANDFL
RKPFSREEFFCRVSQNVDQLELIGTLQDLATRDFLTGLPNRRYFLEQSQRVIPKLLLEDQ
TVTAAMVDIDHFKHINDTWGHEAGDQALRAVAASVSGHARPQDLVARFGGEEFCLLVPGL
DAANATSYFETLRERISALRVRVGDETLSMTVSIGVCIASESDQSLHYLLNEADKHLYLA
KAGGRNQVRLAS
>A0A655VRJ3|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIELNRIEELFDNQQFSLHELVLNELGVYVFVKNRRGEYLYANPLTLKLFEADAQSLFGK
TDHDFFHDDQLSDILAADQQVFETRLSVIHEERAIAKSNGLVRIYRAVKHPILHRVTGEV
IGLIGVSTDITDIVELREQLYQLANTDSLTQLCNRRKLWADFRAAFARAKRLRQPLSCIS
IDIDNFKLINDQFGHDKGDEVLCFLAKLFQSVISDHHFCGRVGGEEFIIVLENTHVETAF
XXXXXXXXXXXXXXXXANVLQSIRSLNKTSTSTSVRGFPACIMVIMTLPIFIDAPIKHCI
KPSVMVVTVAVSIANPQNKLHLASLILFLFVFVKND
>A0A655WPH5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLDLNGFKQINDTYGHQMGDAVLKQVAYRLNNSIPSFDYRVFRMGGDEFAIILSSINSTE
QMMMQRMIKQCFDHEFELSGDLRAKLNTSVGVSTYPLDSTNLSQLIHLADKNMYEMKFLQ
KXXXXXXXXXXPKVYHRL
>A0A1V5U355|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin248|TrEMBL
MDEKSNKVNEALAFPLGERFQADLEKALESGGAVIAMADLDRFLQVNEGFGSDEGDRVLI
EAGLTLKNSLAQGAAVYRYGGDEFGILFLDNPEKEDVFLALEKIRSGCAIKLPDGSAVTF
TMGIACAPDDAAAAGELIRKAEGAMYRGKLAGGNRVCFPREDKMVPKTTHYTAEQLKRLT
KLSGREGVGEAALLREALDALLKKYDV
>A0A656BHB7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLCKRAIDENCFFSDEV
PDRWGDCIAARNLGISTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIA
QYIQKEALVEQLREANAALIAQSYTDSLTGLPNPRAIFENLTTLFSLARHLNHKIMIAFI
DLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISS
LRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKT
PFVAHSAPHC
>A0A8G1GZY9|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MNTIETLGEVLGDEYDVHFALSAEQALSHIERKLPELILLDIMMPEVDGFKFCEIIKSKL
ETRDIPIIFISSLSSPEQETRGLEAGAVDYIIKPFNASIVRARVHNHLELKRTKDLLRVL
SQTDVLTGMANRRRLFELLDQVQDRSLRLTQPLSILLIDVDSFKQYNDLYGHISGDVCLQ
RVAGVIQSSLRSVTDVAARYGGEEFCCVLENADQELALQIAERIRSSIEALQIPHLNSAV
TTCVTVSIGIATSSTASRIQHAQLLMNADKALYAAKDQGRNQVRHASVHFL
>A0A0P7WLW7|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. HL-58|TrEMBL
MNNILDKLAVTVTEEQDLGSLVRSLLELLEAVTGLESTYLTSVDQDEGVQRIIFSRNSKQ
LDIPEGLTVPWGDTLCKRALDEGQMYSDNVSADWGDSEAARALGLRTYISEPVCIGENEL
YGTLCGASRDKIRVSDHARRLLSLFGKLIARQLERDQLLATLRREHITLTQYALTDPLTG
IPNRRAMEAELKRSLANARRTDNAVHLAFIDLDGFKAINDEHGHDAGDRFLIEMARSLKS
GIQEGDLVARIGGDEFVVFGGACAGDHKAGRTAIRKRLEELTRGTFNLGTTTINYAGASV
GVVTSEPGVENPDDMLRQADEEMYAIKQERRLRTAQEA
>D2A8V4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A173XPF7|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MFPKYTTALGKEGIVMENNELQYNLRKFEEDENHIEYFISIFPEYIKSNPEKAKEILDLV
MEIALNKEYELAYGWCLMYIGWYCFTISDYTNACKYRLDANEIFIKNNCVKGLIFSYNGL
LADYTRLGNLELAIESGLSGIDLAEKENDEKALIHLMINTAIAYMDYRKYDEAKRLLNKI
NEVYRQIQGSELIVYYITLAEVEVISGDINKGYECCEVAIELIKELGCWIYECEILSIRA
EANSKLGKNKEAEIDFEVAIKSAKSFKNIIYIVKTLRRWAKHYNRIDELDKAEKKLIEAF
NEVNSLNSLLDKSEICYELNELYAQLKRYEEAYKFLKEHLEIEKEIFNNKSSSWLARLHN
KEITREAKIYRELYQEIDLLSGIGKKFTSDLKIERNLEVIYEEVKELMEADVFGIASYSK
EEKILKYDLFIVNGKRKNCGISALEEENFGTWCYKNKENIVINDMENEYRKYVPSRNKGI
EDDNCNVKNIKSAIFCPIVVENEVLGILTVQSYKKNSYNKNTVKKLEILASYIAIALENA
KLFKNIEYSATHDWLTDVYNRKEILKRGQTIIQNNKGCSVMIMDIDYFKSINDNYGHATG
DYVLKTISDLMKKDIKGNGYIGRYGGEEFLIVVNSSNKEYVSVLANNIRKNIENYNFIVD
SKKINVTVSIGVYNYLKDDKYFNKHIKLADEALYLAKLFGRNRVVNY
>A0A482PE48|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium|TrEMBL
MPHETTTENWGWLKKLARRYGPGHVVNLCFLIVMIFSTLLTWREVVVLEEAYIASQRNHL
ENVASGLDKQLQFNIDKLLFLRNGMHEALITPLNFSALKDAVSRFAELRVTQGWQLELDK
RRTLPLNGVSDAFVNQSHFLSRDGEALSNELTAALEVGYLLRLAPTQSSMAHEAMYVSRA
GFYVSTRSTPLAGEIASRYYDYVIQPWFNEQSQRQNRTRAVRWFTTPSPQLSHDEQLVTV
SVPLDSNHYWHGVLAMSIPLAGVERFMEEAIDKDVEGEYQLYDSRLRMLAASTPELRNAN
TFDARELAMLAHDIEHDTEGGLRMGSRYISWQRLDHFDGVLVRIHTLSEGVQGDFGSISI
ALVMLWTLFTAMLIISWVVIRHMVSNMFEMQSSLQWQAWHDTLTRLYNRGALFGKARHLA
QRCQAQKQPFSVIQIDLDHFKSINDRFGHQAGDRVLTHAASLISGTLRADDVAGRVGGEE
FCVVLPATTLAQAEAIAERIRQRLNEKELLVAKSTTLRISASLGVSSAQENDDYDFEQLQ
SLADRRLYLAKQMGRNRVCITDRG
>A0A7X0D9A2|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus tengchongensis|TrEMBL
MIKQFIANSGILIAGFYLISKFFPLNIHKQSPFYMRLLAGAFCGLLSIVLMLFSIPLGHG
VIADLRHIPLIVVSYYGGMPSALAAGIIMGAGRFLFGNMFASLVSFFISLAIAIGCGLIS
RWMKRNIAVTTFWMNAYSMCFISFALFINIPDRYIYTETLVIFWPISIIATYIAANICKD
IRQSKDLLQHYKAWATTDFLTGLYNVRQFHTVLNEKMAQVKQQNNCLALILFDIDRFKSV
NDVYGHDGGDVILRHLGELIRSLVPKNGLAFRNGGEEFSILLISCEHEAVTFAEHVRTTI
ERYPFVVQKQTVHITVSIGISLFPTLATNETELFKQADIALYEAKQQGRNRTVVYKGTLA
>A0A5P9J3Y8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MRFNPFRTHPLLAHISIAWLVLAALLSYQLGELKYSGDIAWLDILGEGSIVLMTLSWIVA
LLVSRPPGKVTTLLVLGLGLFMFSASLDLLDEWLHQPSRYWLSWIESLPAPIGMLFTSAG
LYWWHQEQFVLNRQLARREAHMRDHQKVCPVTGLYRIQYVQKVFDSSRENEAKCCIAMID
VESFATVNARFGLATGDRLLRELSDLMVMNIRMGDVLSRYASDCFILLLPATASRQAQQL
IAQLQSAIRHCAFRLDPQGQAHYINTYSAVIETAKDESLPKLLRQLQQQLQQQKHRPGQG
DATLCASR
>A0A385ZG48|diguanylate cyclase|EC 2.7.7.65|Streptomyces griseorubiginosus|TrEMBL
MNARLALLGTVTPGATESEVFRLALGHAVGELSALGGTMHLRGPMSALRLVSSVGLPPAL
TRSWEIVDQEGPLAPARALQQGKGVWVPLSPGGENTGRDTGRNTTGRATAGRDTTGRDTA
GRDTPGQDTPDDVPWPGTGLAALPVFSGRRSVGALTVLAGEGGEPTPAHWDFLRDVVAWT
EDRMAQAPPASGPTHAQRSGERLRQALKEVQVGSWDWDIRNGDLIWDDAALALYGTRPAD
FTGRIDNWMRIVHPDDLAPTLAAAQRAILDHSVYEAEYRVRRLDGTWGWTQARGRATYDE
QGEPLRMIGVGWESNESRTARDALGRALRHMSDGFLAVDDEWRITFANLEAERFLGFSEE
ELFGRLLWDLSATRQVPGLKESCLAAAAEERPAGFDVHLAQCERRLHVRLVPGPDGRTLY
FQDVTEKRRLAEERQAAERAAAERALRIAELTTELAKATTSRDVVDAVARRVLPPFAAAG
LMVQVSEGDRLHHVGAAGYPAEFVDLLDSRPRSTTGDPAWDTIETGVPLFMSSPHEYAAR
YPELADFPARGNKRSWAFLPLTASGHTFGVCVVSFDRPRLLDDEDRALLTTIAALLAQSL
ERARLYDAEHTRSRELQRSLLPQDLPDLPACTAAARYLPAGPGADVGGDWYDIIPLSGGQ
VALVVGDVMGHGLPEAATMGRLRTAVHTLADLELPPAEILGHLNDIVGAMGEASYATCLY
ALYDSTTRVCSLARAGHPPPALVHPDGTVHFPEPDADPPLGAAKPPFETVEFEVPEGSLL
VLYTDGLVESARREIDEGMAELARLLAAAHADGTAVDLERLCDTLTVGLLPTDQQAADDA
AFLVARLHALPADRMASWRLPDDPKAASQARRHVREQLASWDLDDLVPTTELLVSELVGN
VVRHARGPVRLRLLHSAGLICEVYDGSQTMPRIRRATETDEGGRGLQLISALSTHWGARY
TPTGKCIWTQQSPRDPDQSSDLLFLNAGDLGGDFTGDFDGDFDGGWDSLL
>A0A6I2I6J0|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT714|TrEMBL
MFPKIMNDENFYNKDVTREEWEHSLSQDDYHRSGIRFARRVRLPRLFGLAAMFFPIAGAL
VAQTPSGGWWLLLVGWAFVWPHLAWQLANRSADPRSCEILSLKADAIVAGIWIGLMGVDV
LPTAALVMMIAMNLTGAGGIKLLSAGAVITAIAALVTLQLTGIAPVFTFTPLELWLTLPV
IVLYPVVFAWVSYQTAIRLAEHKRRLELMSTRDGMTGVFNRRHWEILLRNEYEKCRRGHC
EAAILIIDIDHFKTINDTWGHDVGDEAIIAVTRQLQLTLRAGDLIGRFGGDEFAVIMSGT
PAENAISAMSRVHERLATLTLPCAPQVRLRISVGVAPLTPEFGHYREWLKAADVALYKAK
NAGRNRTEVAA
>A0A564TCV6|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MKKAKQKWFLRILVWLAAVLVLLGVADSCRVQEDPHRTLVQGSLQELNDSWTLETDQQAV
YDIPESMGESLMLSIRSTKQKFSLGLRAADGQEKAFYTYDPGSGPAEMRLFAALPEGAAG
KTLVLRCAEPSALSAMLSSESVLATQTKLSSYYFRRSLYALMFFLLCVLCAVELGVLMVT
MHSIFTPEVRHQTRVLIGLMLDAGIWILTDSELLALVTDRANLVVFVSLVTFSLTVPFTL
EFVRCTIRNDGWLIRLPQMAALVLLAADAAGWLLAGQPMLWLLMPIHITVIASILAAFHT
LVVSYKKNHSGEVRNILLAFGVLAAGALLALATFYSGYRGRTYAVCYCAGLLGFLVMLGR
IVLHRIRQAINEQAQLENYKKLAYADSLTGLFNYTAFKYMKSRWPERTDWTYIVIDVNWL
KQTNDQYGHRAGDELLCCAARCIREAFYRAEDCIRIGGDEFAVIAAATDEEAVKAAVETL
RRLCAEWDAKEEYPVSIAVGYAMQAGRTMTADELFMEADAAMYQNKAEIKKAVGGISR
>A0A653KEA0|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MKAKTKAWPLLVVLYLSILLFTGSTLYCLAQIQNATRVMEKYTYDVSWALMQLQLELGRF
LNSVEIYHYGGIDHDTLMLRYDILWSRTPILLSGQLRQSMKDKQKTLRLVQLIESNIREM
ESNITNLKSGTPDYQQIMMRLAPLQEPLSYSLASVMQKNINVYSGNDKRFGQLRNALLFM
VSGLVLSVMLLSGLLIREARRHFRAARVDPLTGLVNRLALLEKMESYATKEIPFGLVLVD
INDFRDINSKFGYNTGDFLLQEMAKRVRGLCENGEWVARLGGDQFAIIQRESSDLRQVRE
LVVRLLHALKQDIIIDNYPFRLEVGIGIAFFPMDSKLTQELLSRAEQALFHSRKTHVPYV
IYDNSLLNETARRKHLASDMIMALEHNALELYYQPIVNLESGRCEAVEALLRWRHPELGF
IPPNEVIQVAEEFQLAEKLGSWVLNTACEQLYQWQQLGLVDLQMCVNISPGMYQRNLLKL
VAKALMDHHIPAASLVLEVTEDTTMREVKNSLQLMQDLNQQGVQLALDDFGTGYSSLSYL
QKLPVSKVKIDRSFIQGIDTSIEASELVANICRMGSMLGKSLVCEGIETQAQLDVLRTLT
DMHLYGQGYLFSRPEQAEKIYQTLLEMEEAWLKRSQPGKAYLI
>A0A1V4IHW9|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MNQNSISNDKLLEIIKVQTEVAQQGMDLGNIMDLVTQRTKLITNADGASVELIENEELVY
RAASGMAERFLGLRLNMENSLSGECINIRIPLISNDIESDDRVNKEACRQIGLNSMIVMP
LICMNEVVGVLKVLSSKAGHFNDDDIKVLELMSGLIAAEMFNAMKNGESELFYKATHDSL
TGISNRSLFYDNLRKRLSHASRKEEEFGIISLDMDGLKEINDNYGHRAGDAAIKEVALRI
NNTLHETDTVSRLGGDEFGIIIAKIEHSDEIKTLIKQLDFEITKSFEFEGQEINLRASIG
YALFKEDGIEIDVLIEKADKSMYKVKRVRKGHENVR
>A0A447JMH0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Daytona|TrEMBL
MNDENFYQKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVF
GGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAAL
FMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPL
LFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTPADSAI
TAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A381G871|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MIAHNLNALDLLTQPVWIVSPCTEELVFANRIAREVMQGYTFSQLRKGVYSTHAQNTLPN
YITDLRRQRDIVEILTVPRENHQAALTCRLSINDLPGTGEVILFEGIDIPAVQGLKASRS
ATYQRKKQGFYARFFLTNSAPMLLIDPSRDGLIVDANLAALNFYGYSLEAMCQKHTWEIN
MLGRQVLPVMHEIARLPGGHKPLNFVHKIADGTTRHVQTYAGPIEIYGDRLMLCIIHDIT
EQKRLEQELERAALHDALTGLLNRRQFYQLTEQGQMQHLTLAQDYSLLLIDTDRFKSIND
LYGHLKGDEVLCELARNLESCARKGDLVFRWGGEEFVLLLPRTPLETALQLAESIRASVA
KIGLPGLPRFTVSIGVAHREPNESIDELFKRMDAALYRAKNDGRNRVLAA
>A0A379ZVH0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRV
LIEIAKRLAEFGGLRHKAYRMGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A658Z1D1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8I0G2K5|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A447VD25|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A843MBP6|diguanylate cyclase|EC 2.7.7.65|Methanobrevibacter sp|TrEMBL
YKRNIEIATNQNPLTKLPGNNQIEKFNEKSLKRNQKNITHIIYFDFNDFKPFNDIYGFRL
GDRAILVFSELLQKRYPKDSFIAHIGGDDFFVGLRNHKFNEVYDLTNKVQIEFKTSMENL
YSKKDKEKGFIIAKDRFNIERNFNLLSVSSAIIEINPKSNISDFDATLNILKKASKGSPN
PISSIL
>A0A381C4H0|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MSTSLANRFRLPMVNTLRVIHLCFIFVFVLTTVLFWQQGQLFSQGYRTSQLSHLESVIAR
IESRAQYKMDNLRYLRHIFLEAMDDPMFPGSVTAPWDTNSGVVETPLWIGELPLPDSVSK
NESFQDELEPLEVRQELNALRKIQGLFPLASRGSDLIADLYYISREGEFIVSLSQQVNSL
LIDSYNPHEKQGSFVLASPLLNPLREPFWTRQNIAKTNDTLINGAIPVDFRGEWIGLLGI
AFSNESIQNFVSSSLPEGTQSAYQLFDEQLNPLTKVAGMENGFQLNAQQIATIRKMLTEK
SRGTLRAGTVFITFGEMSGTRSILVGTQSLSQGLHEEFGRFSILLVTMWLIFVLFLLGSH
SVICRLVRNMGGLQREMQHHALHDDLTGALNRRGFFAKTSQIMSDNVDYTLVQLDLDHFK
NVNDVYGHLVGDNVLVHATQRIQRAIRNQDILGRIGGEEFCIYLPNSDLKAGIMVATRIK
WELESSEMILEDGSSLPVTASLGVTSHSEFPEYTLDQIQARADMRMYRAKERGRNQVCWQ
DEDIQA
>A0A5E4XW12|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MKRTLLSAVPLTGHLRWLNFAVVGSVVVLCVGLLTWSWGTYQRARDASLALEALRATLLA
MEKASAERGPANAVLGADLPLPNASVTALRNAREATNARLQELLSALSTDRCDACGSSLR
VVERARLDLAAASANVDLLVQRPREKRSDADVRDAVDRMIRVIPEFTSVASSRIDVISRG
APDALHYVVLARLAADLRESAGQLGSHFTASLTTGAPLTEADQRTLERTLGRIDQLHDMI
AARMIDPPELGPKALDALNAQYFTAGLHYVATVRTLASSPAHVAPTTAEFAGHYVPTMHA
ITDFRDTMLTLARRNVDAQASLALKWLVGTALATLALGLAMVVLLRHIRRHVVLPFEAAT
RCVNALAQGHLDGAVPGEGVPMYRPQVRAVFDALRVLRLNALELRQLRGERARLLGDLEM
SADTDPLTQLMNWQAFVRQAQALWAMPTPGLVALIKLDVDHFTQINATWGHGAGDDVLRR
VGAVCLNTSQPGDVVARLGADGFVILARVLDPIRAQQFADLLRGRIEATALTLPNGERVS
LTASVGIAIGDPATFGGATPMSGGAPAAVSALLSEAERQLHAARRARRHVIE
>A0A7W5XBI2|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK619|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKANRKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLMRAGEGRADETGQILLVDGRANSQERIIKAVKPVAD
VLALSDPQAALFEAAESAFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRCNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAVENAPFMLKHAGEALNVTASFGI
ASRIGSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A6N3HIF0|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MALHSKKLSFTRPIMLSFAGILCSFALIAVVVSLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRSAMYFARSEILNETLNVNPTQGLQMLMHLQNLMPTVSSISLADTEGH
YLHAPEAPPTEKSKNVDPRTRPWFVAHAEASIFSHYTHHYTDYFTGHPTVTLYKPLISTE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGTVVLHPDTGALFKKYVSEALMD
KMTSGEGHLYDRKTNAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRTVLMTIINAIKTGDVSQAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDNDVDELLIAHQPFALALIDIDNFKSINDTWGHLSGDIVLRNVAREGIQI
MQPHNISVYRYGGEEFAVIFQAEQIAAAFSLLDAWRTAVERRVWREENLHVTFSAGLGEW
HFEPLEQLVGSVDNALYSAKQQGKNRIVRTTVG
>A0A1V4VV71|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MVDFYVFVILVALFMYVLVVNDITVLYKAYLVFHYLLGMWPFCNFLINVTPDQQLQWVFL
SAAFVSLCFLGFGWHIFALVLTGKIKNVKKAYLYLWAVPAVFCSLLVITNPWHFLFAKPS
LNGWATRTYGPFFWLFVFSIIIYFIVGGALMIYELATVSEKNKKKQLMLCIWGVVSFLAL
SITDVLLNAFILPETVVVPGLTSSGLIILAICFVVAIQKYDLFKIVSIAQREVIDSMATG
MVIIDKNEVVLDINKSAGRLINLQPGHVFNVGEFYPASGIEFDGEFLEEYGGDKSKILQT
EIIINQEQPRHVAMNISPVFDHKKNLLGRSITLNDVTELRGLIEKINENNETLKLQNEEL
LQFQSKLYKANRKLEQMSITDALTGCYNKRYILNQLDYEIAAARRYSIPFSLMLLDLDKF
KLINDTYGHLAGDDVLRGVVDIVNKNLRRSDILARFGGEEFIIYIPHIDHDGAVALANRI
RSMLENQTVKTMIGELSVTISIGLISVIKVESINIEEDFLKDLLARADNALADNALYEAK
LNGRNCIVAEVFD
>A0A386HC91|diguanylate cyclase|EC 2.7.7.65|Yersinia rochesterensis|TrEMBL
MDLSAAEKPAPDNKAIIHITIISIVVFLLALFCIRLSEQSENLAPLWFPTAVLVVALFHL
PTRYWSWQLLAAGICIVAANFILYGISGFPLPLTFINLAESAAGAWLLRKLLQPKDPLNN
LFSWLKFALCAVILVPLISGLAAAWYLAPQNGSFTQVLTVWFMSEAIGMLALGPVGLLYR
RGYFNLATKTKALFDMTWIMIVSLTACYISLIYMPYPFTFVIMALIWTSIRLPRFETFTL
CFLATLLIAMMINFNLFTLQADAKLSVQAFSFIPLLMVLIPPHAMAMVMHAFRMEKKHII
ESENRFRNAMEYSAIGMALVSPEGKWMQVNQALCKLLGYRQETLLTLNFQQITHPEDLSA
DLKLLEDLYHGRIPSYSMEKRYIRSDGEVVWALLVVSVVRDHEQQPLYYISQVEDINDLK
KSEIVNRRLMERITLANEAGGIGIWELDIRKQQISWDKRMYELYHVPLNTPVDNDVWQQY
IHPDDINRVNREYSAALNQRKPYRLEFRLLLPNGDIVHLRNQANMICDKNGDILRLMGTT
LDMTEIRNLTEALHEEKERLHITLDSIGEAVVCTDQDMNITFMNPVAEKMTGWANTIALG
QPVHHIIKLTDGVDGPEIDNPIEHCLTHRPYSSLNESMVLHHRDGHYYDIQESVAPLKTL
EGTIVGVVLVFQDVGESRAMIRKLSHSASHDNLTGLPNRANFDNKLKAAIQKSVDSNQQH
ALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHLRNSDCVARLGGDEFGLLMLNCTL
SHAKAITQSLVSMINDYHFYWEDKLYRIGASAGVTQISSNNSQRSEIMAQADIACYTAKH
SGRGQVYLYQPRQKQLLARQHGLLSREDVESILRENQLSLQMTPTAPPKTPLSVCFYQVS
FEINRPQDIAVSQSAFEEAAVLYNLQPEIDHWVCEQLLVEHAPALQRKGLALAIPLSEVA
LLKEDFRQSLLTLLPQTPLPPQSLYWMVDEATLLQYPFAIGNFLAKLQLLGCKLIVKEFG
HNLNDFELLAAHTIDYLKFNSNLISNIHTNQMDEVLISIINGTAQRANIATLAGPAELPP
TLSKLIDIGVDLVDGETIGRTQPLSEVLNSGYFAIK
>A0A011PU99|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MIEDDMLHDATTDGVVPMAGLLAMLMNTGCAVGFGVKALDGSYRVANQTLEQLLSQGGRA
LLGKSDSELLPVDVMTALARADRRIRAGATAAAEEVELAVDARRARYLWLELPVLDQDRM
LQAIASLVYACSPQQAPDSLLQTLDRLQQANQELQQTVAELEQLASTDKLTGLWNRRRLE
DCVRREIERFERYQHPLSLLLFDIDCFKAINDRYGHATGDEVLQRVAALLQGGLRGADSL
ARWGGEEFVVLCPDTNRATARRLAERLRAQVGKARFPQVGQLTVSVGVAECDAGESWGEW
FQRADEALYRAKAQGRNQVQLAPGADRPLGTGEGAAANFVQLVWRSAYECGNETIDGGHR
QLFSNANDLLAAILSERSADDVKALVDRLLADVRQHFAEEEAVFVAAGFPDAAAHVALHR
QLIAQSLRMGEDYSAGKQGLGEIFQFLAHDVVTKHLLGADRKFFDHLQRKATFAG
>A0A1C3JCB9|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MTLYKQLVVGMVAVFILLMTSVFMIEFNTTRGYLEEQQRSEVSNTINTVGLALAPYLEEK
DKVAVESVINALFDGSSYSVVRLIFLDSGEDILRSYPVKPTGVPEWFTNLNLFEPVHDRR
VITSGWMQLAEVEIVSHPGPAYDQLWQAFIRLLSIFGTIFLLGLVSISWILKRALRPLSL
IITKMDQIAKNQFGEPLARPKTKDLTLVVDGINHMSTQVELAFKNQAKEAQKLRERAYID
PVSQLGNRAYYMSQLTQWLEESSLGGLAVLKAEFISEEYDEKGYQEGDALVHQLAEQLQA
SISSPDITIARISSDEFGFIMPNIDESELKLVASSIVNCIQGLGSDPTGTANPHIALGVT
YSNTRKTSTEIMSLVDNALSSAKANRELSYGYVTADDHGAVMGKQQWRMLVEEAIINDLI
TFRLQAANNAFGKTYHQEVFSAIEKDGVRYGANQYLYALEQLEMSHILDQYVIEKMIEKL
NAKEVTSPVAINISPSSISQPSFIRWIGKTLEQNASIAHLLHFEIPENCFINVPHYTALL
CNTIRNAEAVFGVDNYGRNFQSLDYINEYRPSYVKLDYLFTHNLDDEKQKFTLTSISRTA
HNLGVTTIASRIETQTQLDILSDNYVEVFQGFIVDK
>A0A1C3JHW9|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MENQGVTRSLAELTQIINALEYNITALYPLHGDTYVFSHDKKIEGETCYFTSEEQHAPRF
DFMFSGPREMCNPKSDLYTEAGKRLFIAPTMAYFANTIDTISAIYFISKEKFIISSPSDF
ASYIKGDTFDSVVNSRPYWVNTIRFGLAQGQDQVVYTGQYDDYLTGQKVVTLTKGIYVNG
EFKGVLGVDGYVSNLVSNPTHGYKVTSTRGANKYGFMDFTYSKPLYVDDIDTQLYLSIEE
DKSEHFLHILEMEKIQLSILLVLYLLSVLWLWRFYTRQEHQRLNELAMRDPLTGLLNRRG
FEARLLAQDEEPIIGVGVFDIDDFKVVNDQHGHKVGDEVICHVARLMLNSVRQQDIVARF
GGEEFVVAITGESSELLSSIFERIQNDISLQSYRCPTGDKISISVSGGATLYSLYKFDSV
GHLWENQSIRSSDEQLYKAKAAGKNQVCIQVY
>A0A011PA32|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-94|TrEMBL
MSASTGAADDDQPLYWAPSLAFLKYAGWAILLTACGVLPTILLLIPEQPLRALGPAAMIV
VAAATLRLLAVGRLRASLAVLVWGTWLAVVGITLFYGGLRGSLVILYPLLIMTGGWLLGA
RAALALAVLTGALISALLLADWRHWLPAPPATPPLMYGLIQLSAVIVALLLISFLSRSYQ
RRIAEVRRLGQDLEQRSAELLANEAELRRAQQVAHVGSWVYDLASDTIRPSPEACRIFGV
PEGSMGTLAGFMKRVHPDDQRILQQDIEAALRGDPFDSELRIITDGGVRWVAQRAEVEFT
ADGRALRSLGTSQDITDRKELEASLREQKEFFRLISESIGEHIAVLDLQGRRLYNSPSYR
QFFGDTSELPGTDSFADIHPDDRERVQEVFRQTVRSGVGQEIEYRLRRRDGGVRHMHSVG
RVIRDQQGQPQRIVVVSHDLTDRRQAEQWERIAATAFESEQGMFITDADGIILRVNQAFT
AITGYSAAEAVGQTPRLLRSGRHDALFYAAMRESLARTGAWQGEIWNRRKNDEIYPEWLT
ISAVSDNQGRVTHYVSMLTDITLRKATQEEIKQLAFYDVLTGLCADRLAEPAAVARPPAH
RHGGKRPSRAAGRPAVHRPRQLQDAQRHARP
>A0A485DSQ3|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNAASAIFSMILPSPEVPAVTLPLVMIMVISLSVAAY
FIFISKNYVDKLNLFSIIMGILWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPAALTVIFLDDFQNIFRIIFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQPYDLASSLKAADEALYRAKKDGRNKVAFAEDKLSKIESSP
>A0A128FIM2|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MLSYKFSRTLIAVFVLLFFSAATVVWFYIGGAQSSYVISPEEFQFRYVDDTPMGGDTQGR
VYTSESGDVVLECVLGSAYRWSFCEVAISLSPSVTRGIDLGNYHSMIIESAYKAPEPDER
LRVYLRNFNEAYSTKEDPVSMKFNGIEYNPTEEVSEIVLPLNSFQVLSWWISDFDVPLEH
AGPDMSNISLIEIATGSAPILGKHELIIKSVRFEGMMVTEASLFRSLTFIWLFTATILLA
VKYVQSRRVYDLERRRANRLKAINTALKHQSETLSIMATTDALTGLRNRMDIYRELEKAL
ASTNGQNCTALCLDIDHFKKINDTYGHDMGDRLLISTAEVLRESVSSSDVIVRWGGEEFV
IFCPNRNLAQASFLAEKIRFAFETMDWPHQADLTCSVGVSSMREGSIAAMIADADDALYR
AKQNGRNRVEVFAESFIAAV
>A0A0J6Z7E0|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MSAAQQWWALPDQYDWLSGYLHARRFDRPVRIGMAMISGAAVLFPLNALYDPGQVHGRVF
LVVSVVVAAVHLGWLVLWLARWPTRGQSIAYGLCFSASVAASTWIAGVPSIGLVGCTALA
LPGIYFAFFHSSRLVTVNFAVALAVAGYHSVDLIRDGQAILAASMIVLVLQLNAVVPLVF
QIAVHALGIDLIQSDRDPLTGLLNRRSFEREVVRAVLDGQHSGSHLVLVMIDLDRFKALN
DAKGHSTGDDALVSIGHALTAEMPASSAIGRVGGEEFLVADIVAATQIPALAERARHAIT
LGRHSLTASVGTAAIDTAGIDSTNIVDTLQRLTAQADVAMYQAKRAGGNRVHHYVSDAK
>A0A624B5H3|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARLSAMLTLETMYVSRS
GFYLSTLPTTYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAIDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>B2TXJ1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MENQSWLKKIARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEAVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A8E5JM71|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Enteritidis str. 607307-2|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G0U6C1|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. MG28|TrEMBL
METESEPYVRLTTLRQLHQVMADMNTARSLADTLQTVADGVVNGLGYELACVNLVRPDGD
LVVAALSGNSAAEALITGRVGSRASWDRRLSMGEAWGDLRFIPHTEGWVLDEDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYTPGAGGASCGELLGVVSVDRPRNGRRPGAWGREALQMY
AFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHG
RILRTNDALCRLLGRPASAMRRYAFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVW
VSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDALTGLPNSAELRSRLSAR
LCQRPQSLPAGAAADSMNAAFGQFGEQVDGGGHGEFGEFGAEQAARLPHPSFDAYEAAGH
AFDFHAAGGPYDAFDHHVHTVAPENERDDGTKGLAVLFCDLDGFKSINDRFGHNAGDAVL
IEVARRLSRGVRDGDTVARLGGDEFVVLADGLGRADAQDLAVRLRNEIIQPIRVDGRAMR
VGASFGIGWAHCGMTADEVLKSADERMYVEKRSRPRQHRRAG
>A0A8I0UFE9|diguanylate cyclase|EC 2.7.7.65|Gluconobacter japonicus|TrEMBL
MTVDTLPSITSSLSPDEREWQLIIDAVDPRIRLIVAKTVEERAPEGVEFFYTTLLNHPEA
SPFLSNQIVNDHLHSALLKWCLSLFSALAPDLSSLIATQRRIGLVHARIRVPLHVVMHGA
RLLKSTLRQSLFDSALSSKDLSTAINYVENMMDLAIETMSREFVRDLQKEIETDEAYRLI
TLGQDVTLEREVQRAALLDWGHKILLSICCNAPPPLPLLESSGFGLWLNHKGSLLFPNTS
GIEHIRTAIRRIDHVLVPSLALEIPPAATRIHELQAQIEEIRFLMDDLFKESEALESGRD
PLTCTLNRRFLPTIMAREVAQSIRRQVPFSILMIDIDHFKAINDRYGHTGGDAVLRQVAE
KLVASCRTSDFIFRYGGEEFLVALVETDAQRAFQVAENIRENITQISTQPTGSTSSVTAS
IGVAHFEGHPDYTHLIEDADRALYYAKARGRNCTVIATPNLDSLPRY
>B2U3Y7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>L0NGK6|diguanylate cyclase|EC 2.7.7.65|Pseudorhizobium banfieldiae|TrEMBL
MTSKHFPDVSRDTAPQDIYRKIVSEIDDGVIGIDAGGIIRLCNPSAERIFGWEYGELLGK
PLDVLLPEHLRAFHAKLVSNFFAGAGEARYMGARTAEIVGLRADGSEVHLGITILKTSTT
SEHMMIAVIRDISERISYQRELLRLAQTDPLTGLLNRRAFHESFAARMAHGEPAMSSVAL
LDLDEFKALNDRYGHDAGDEAIIRFADILRQTIRSGDLAARWGGEEFILFLPNTSSQSAV
AVVERVRAAFADAVFGWRRGGSGSLTVSAGIVTDRIGKGGLDAAVARADIALYDAKRGGR
NRIVRIRDPQDTVAMSADH
>A0A829DJX4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2875150|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAGHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRGFASDNA
>A0A8E5NBW8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Enteritidis str. 607307-2|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A222P5G1|diguanylate cyclase|EC 2.7.7.65|Legionella clemsonensis|TrEMBL
MGQVDELVNPLRHTLSKMELALGTINEAIIWVDEIGIVQWCNKTFDHLINKRHIEILGSN
ISQLLPLKNKHKLSWKKLLKAAITDNSTNEIYTYHRNDSEFFLEMRTSHLILDNKTTIII
VLKDVTAEQHYLSELLKKEKLLRKQSDLLARDKEYVDNIIRSMSNMLIVVDKNGMITTVN
QATASMLGYKMEELLGKNLHILFSDESYPEVLNKIISSKSLTNLEANCKTKNGHIKPVLL
SGSVMFDTDGNPSSIVTIAQDISERKDMENRLLYLSTHDSLTGLPNRAVFEEALEAAVQR
VKRTNQSMALLYIDLDYFKNVNDTFGHRIGDLLLIAISESLRNSIRKDDLALRLGGDEFA
IILNGVKSPKNAYKIVEHLLHNIAKKYTLEGNKVFMTASVGLAFYRTTDGLSTQELKKNA
DLALYQAKEQGRNTYQEYNVI
>A0A238DLC6|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MQMLMEFLQLSEPEAQALADCAPELALRAEAFARSFQSSIQTPSTRDAMLSSLSDEQCRQ
LVSMQARHYRELLEAQYTLELQHRMVEVGSLYYQWGLQPIWIMSASALFAADFEAYAADL
ALQQRRPLMAALYKRLRRDEAWQMEGYRQAGESVRRQLEQRPLRDPLTGLLNRAALDELL
PNALARARRHGTKVVVAVLDLDDFRTLNQVHGTALGDLVLEQLASRLRRALRKTDLVVRL
EADTFALVLEDIQRIANIAPLLERLQLDLDVPYTLSDTLLWQCPLSMGITLYPDDNQDSA
GLLRHATQTMQAMKDNKSQREQFWAVYTPPA
>A0A1A8TRL1|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MTKCVRFTHFVACNILGCYVTISVIVYGALLFAYHAEVQEKQKRQIDNTIYLLIQQIKGS
SVTSLGSTDLSLDDSGLFFEVCHQLDREGVKGIFLQSADHYTPILDHINKETSALETWVY
PFSARNQSMRLSAYVSNDKVWRVFIHRLLWYMGLLFIQTAIIYLLLYYFVVRGLGMAVSG
IQQELSQMNLDDPKRLYGNAKFLRFLEYQWILNGMNKIIHGLAASRRELSELNSQLEEKV
AQKTQSLEEKNMTLVQLNKKLYTLANTDSLTQVYNRTRFDLLFREHVAMAEHKETYLSLL
LIDLDNFKRVNDQFGHQVGDHVLYVTAKLLESVVMNDGIVARWGGEEFAVLLPHIAIDQA
QHIAETLRQHLEEASFDDPAIHITMSVGVSQLLLGESGMSLLKRTDAAMYQAKNTGRNQV
IVDTGPDEKGIS
>A0A380WLC0|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MQSAAAPTERGNDIASTVVATMSQMGVIGLPRNYEIFYEALTGTNAALSLEVIALGNRPT
QEQLDLLGQKFFAHNHGQGIVEHAREVLARELEGVASLLRNEQTYLERYGKVLDETSSGL
SSRTAMSQELLQKIASVMAVATASTIDHGKHVATTLSDKSSELESVKSKLEEYKKLADTD
PLTHIWNRRAFDRRIARIYNDSRGVLFSALILADIDRFKDINDRHGHPVGDKILRIIASI
FQSSVHRDMFVARTGGEEFALIVEGTTEEATFEIADRVRLLVAQTQFRDVQPGVNCGQVT
VSMGVCMASDADSAEDLYAKADRALYRSKLIGRNRVTRYSTIAERQGKNWMLYKKD
>A0A8B4GE72|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAVAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSQAFDPRTRPWFIKQAEASTFSHYTSPYMDFFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSNELMD
KMTSGEGLLYDPGSDTWYYYYSFTNPDWFVIFRVDNTTLVNLTRHETNLVIGGFALAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A3S4TCY6|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MSQVLQHCVRESDVVARWGGEEFVILCQQSSLPLVESLCVRIAERIKHYQFTDNVQLTCS
FGVAKLADNEPMMLCFERADRALYRAKAQGRNQMCTDR
>A0A1G6L7I1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter kookii|TrEMBL
MNTESIATLAAQWKSVCQSFSTTDLNDTFQFIQAHSQTLVYEFYKNIMQEKEASYFLSDD
MVQNRLKTTLNQWLIDCFNVPLQQNFIEIVEKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFLLQAEQVQENSLLIAAYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAS
QKDKQRSSLLDWENDLMFKVFSNEPKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVSVIID
RIHQSDLLSQQVLNAAAREQAIQLIQHIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLHTIVSREINFSRKNNTPLSLLAIDADYFKRINDKFGHAAGDSALKFIGEVLLDSI
KGSDYAFRVGGEEFLLLLVDSDLVRAQEIAEKVRSRIQETTIRTSMGISFNFTVSIGCAL
YDGHPDYQRFLDAADAALYAAKNNGRNCIQVTKQAAKA
>A0A381IP24|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MDTSGTGNSTGSSAELVRYAGLGTAACVVVAAGAAAVLFQGQADGSFWRGVIGAGVVAGV
IAAPLLTIIANERRKFGALKSEVSRLSSVDALTSCLNGSVFASLIDAFRNSPSSRQGALL
VVDIDDFRAINARFGHAWGDEVLKIVAGAIKSSVRGGDLVGRIGGEEFGVFLPGASKENA
ERVAERIRGSISDTVLEPGGRNCPLTVSVGAVLFDDQFEFDEMFRKADGRLTEAKARGRN
RVEFTDMSEDSDDKPTLNA
>A0A1J5TCR7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLGTCHASIITSTLLAAVLAYVQRDVIAPGVIVVWLALVVLVALFRAMIAVVCKRSALDE
SATTCAQLTRFRLGVLAAGIVWGAAGIVMFPANDPYHQIFLIFMLAGLTAGGVISYAADL
IGATGFSIAALLPAIVRLLASGDHTSQAMGMASLLYLAFMIVSLRYMHRHIRENIELRLA
ASTREEAARAEEERYRLLLNHSPVGILHYDTDLVITYCNQRFADILHAPLERLIGLDMKT
LRDRVVLPALKQALQGELGYYEGPYTSTLSEVHKWVAMTCAPSRNGSGRIVGGVGIVQDV
TALHESHQRMFSLLNSMAEGAYGVDVDGNCTFVNRAFLRILGYDQADEIIGKHIHELIHH
SHPDGSHYPASECRMYSAYRNNLEIHATDEVFWTRDGKAIPVEYWSQPLLEKGVMQGAIA
TFVDISERKQMLAELRESEERFRQMFERHSAVMLLIEPGSGMIVDANPAAARFYGYPLEN
LRGKLLSSINTLSEAEIAREMQHAIDDHRDYFVFDHRLASGEIRTVEVHSSSVHYRNAPL
LFSIIHDVTERKLAEAQIRNLAFYDALTQLPNRRLLNDRLGITAAASMRSGRYAAVMFLD
MDNFKPLNDKYGHAVGDLLLVEVANRLKSCVRQMDTVARFGGDEFVIVLNELDTGKAQSV
AQADSVAQKICRIVSEPYTIKFQTDQGPEKTVTHHCTTSLGALVFTGNKASPDDLIKWAD
KAMYQAKEAGGNSIRFVDPEA
>A0A1J5RIQ4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPIRHQSVEDVIESLEELLRETKPGSSVSVEHLKSACETLTVLNRRFLRTVRVSDNYQIQ
VRSLVDELKEALAKIRSMKGIVHICSSCKQISVDQADWQPLDVYISKRTDTRFTHGMCPD
CSRRLYGDFVPPVSEPAKPEEGAPASGGRTDELDLTDPVVARFLPMVNDPLLADKALHDD
VAELFHKYVRLQRRMKRIAEISDRYQAEFRRAKADQDWAAHGDPLTGLSNRIAFQETLET
ERLSGLASGKLPALVTVKVSNLRDLNHSHGLAAGDQALRAAAVTLRAAVPDLRLCGRWKG
ATLVGLFSADDADPASARVAKLSQTAKAAGEAMTPQAVFEVGWAALRAGDTLEAWLSRAG
AD
>A0A1J5R3F9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MQQRDRGPVVRDRRRSTLPRWVGVGAVAMVLALPAVVVPPLLPRAELVALLRGAGIAGIG
FAVLAGLGRLQLSRRYRTAAALDRALTELAEAHAELGRRQSFTDALLETIEVGIVSCDAD
GVFVVSNRAERAMFGLATGLEGLGPEDLPSLIDVFDTTGRNLSASEYPLMRALRGEVVAH
EDVLVGPVGGPWREIVVHGSQIVAADGTVLGAVAALTDVSAERAARRALAEERRKLAEAQ
ELGQLGGFEYDMPTGRWTFSDELCALWGVHPGRLSAARCFALVVDDDLDRIRATWDAIAV
IPGRHTDEFRIRRASDRTERVIRARTEILVDADGVPSRIRGSHIDITDVAVAERAARRAN
AFSDAVLAASPDNTLVTDVATGAILFSSPGKRLLGMRTETFTNVPVDTLAEHIHPDDRER
LSVVHAAARELADGESRHLRYRARDTDGRWRWLDHTATPFRRDATGAVVEVLAVLRDVTD
VVEAEEQLTHAAHHDNLTGLPNRAFLLETLEGALARSRVDGRDVAVLFCDLDGFKEVNDT
GGHSAGDAVLRETAQRFREVLREGDTVARVGGDEFVIVVEPWKRADPGPSLPAGESARAL
AVDVAERLTRAPQKPITVRGLDHVVRASIGITYATLDPAGAPASVTVDEVLHRADGAMYR
AKDRGGSRYELDDTAPW
>A0A1J5RW75|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MHKSPTIKAQLIAVISFLSLMLVFLGWLGVSNLNKTVHSIHAIYTERVLPLETLKVVSDM
YAVNIVDTAHKTRNGNLNWAQSLSKITEAEQKIQQNWNAYRIAAHLDEEKRLITQAAPLM
ESANKSIAKLKAIVEQHDSKALAYYTSYELYPEIDPITQKISELVAIQLVVAKSEYESSN
KIYQQSFCLSLVAISTSILLATFIGVIFYRSITHVINQAHEYFMRMASGNVHIDIEINGQ
HELSKILEAAQSMKNKLVNDVTQAHETANEFARIKVALDNVSTNVMITDNARNIIYVNQS
ATQTLKKALPPLAQQHTGIQFDKLVGCNIDQFHQIPSEQAKILATLNKTYRTQISIANKA
FRLTANPVVNDTNNRLGIVVEWEDVTDRIALQQKLEDQAQRDFLTGLANRRYFIELAEQE
LLRTLRYKCDLSVLVLDLDYFKKINDAYGHKAGDLVLQQFARTCQVVLREVDIIGRLGGE
EFAVLLPKAAGALAVEIAERLLKAFQDDSVTLDNNETIKFTASIGVATLSNESQSIDEML
QEADAALYRAKHAGRNKVVAAFWRV
>A0A1Y2N7R0|diguanylate cyclase|EC 2.7.7.65|Pseudonocardia autotrophica|TrEMBL
MSGDPSASGARVPGTGNAARRRPFRQLPLRVRLLLIAVEVTAVLLVAAELLRHGPELLEP
RPWIVSGALLVAAALHAELSLGAERMRRRIADTRYIDLSSVWTFAAALLLPAVPAVATVV
AVYLHLFLRVFRPAGTPLHRQLYSTSTVVLAVYLVVMLREYSGVGGDVGSVAGVVTLLCC
LLVYTLTNTLLVVAVIRLSQPRSSFLAILAGGEIVLELATLSLGALVAVVIVPHYWLLVG
LLVPSLLLLEQTTLLRQLEDKANTDAKTGLLNADAWRSRATRLLTAARRDRVAAGVLILD
LDHFKDVNDRYGHLVGDAVLASMADVLTGEVRGTDVVGRFGGEEFVVAMGTMKQDPAAGA
TAVRETCERIRRRVESMSVEVPSLQGAVRIDRLSVSVGAAVQPGAGTELDRLLAAADEAL
YTAKRAGRNQVRVRDHGGGQAGPAR
>A0A1W1HFA3|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MDINKVKDLDTAAFFIEVGKPLAKAKTIKETLDILMYQVGCIFQPMNWSLLLKEPKTGDM
VFTVVVGANKDKLQGVRIPKGEGIAGHILKTGESLIVEKVVEDERFSMRMDEATGFKTQS
IIGVPLKTDDKIFGVIELINKISGDNFTEMEMQVLSSIAEYAAIAIERSYYNQALKKIAL
TDSLTGLRNKISFERFINNRIEVLKRYNVNSSLLMIDIRDFKSINNKYGYNVGDRLLKEF
AKFLHTSFRAVDEVFRYDADKFAVVMPQTSLGKTQQARQRLLTRLESALFLGGKVSISAN
VAIRLVDIDIHNEIQDIINKKGESVRLESNRQSNINNENLESGTLDSEKNSVKADPSDNT
LSRKRAVDNQTADNSAVKGEDVNFSSEIKAYPSESSGYEDDEGENIHDMENNLQPMLDEE
DLELQRDSARNKVQYKYKDVMLPGDYRHFNKNTHGYITVVKISIRAVCFETMRSNTLKPG
DIVDVSFTLDDERKSLIKRRVQIDSVDDKMVEAQYYNPPPYDKNLGFYMMA
>A0A1J5RC91|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLKTCLHRYGIWPTVILVTLLSIAVSAGIASGMTYWVLDGSMTRSAWIITLLTPAVISPV
MTYITLRLVSELDQAHTQLHELIHRDHLTELHNRRYFMQVLHAEIEQARVHGTSFALAIV
DIDNFKTINDRFGHLGGDEVLKQIAHACRSSVRDTDVVARIGGEEFAFLFRASSLAVAQE
LAQRLLIRIRQLDVRLQDIPLPISVSIGMTSVAGPTADLADAMRLADNALYAAKSAGKDR
LEILASAAATA
>A0A1J5R1V0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPSRSTLRAGGDTNPAKAMPHAAVYGALQSSNILEVARASSGARVAPSPCMGRVGVGRGA
DGQESGTQASRDNRPWLAVPAALCLPAAGGCRSPPSPRITPHHAQAPVPQSPSRPPSYAA
SATREQTYRYIYPMRVLGMGLGGVAAGSVLFEQQAPQAYWWILVATCFVWPHLAYLLARR
SKERYRAEKRNLLIDSAIAGLWVSLMHFNLLPSLVLVTVTTFDKLSTGIKRLWLHSLPVL
LGAAGLATLLTRPEPMLQSSHLVVLCTLPLIIVHTLASSIGSYRLIRTVSRQNRQLEELR
RTDSQTGLYTRDHWQERAAAALRDFRERGEPAYLLMIDIDRFKFINDTLGHSAGDEVISA
VGHVIRDCVRAHDSAGRYGGDEFAVVCGDTQAGAARAIAERIRACVEDLRLPEQPDLRLT
CSIGLAAAQARHDNLRAWMNDADAALYRAKNDGRNQVSGAAATTHTAA
>A0A1J5REU9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MGLDPRTLVISASLSALLMAVVFFFQARSFPQRIRGLREWGFAFLTIFAATMLIGLHGRI
PDFVSIVLANIALQAGYLACFVGLRRFRERSVDFRPLAALLALNFLLLLYFLYVKDSLEA
RIAIITASNILICIASLITLLRDRPTAMLRFGEAFTAVFIIAAAAVAALRGAIAIWIDPK
LNDVMAATGPQSFDTAAGALCIFALAIGLVLMAYDRLKDELEYLVRHDYLTGTLTRRSFF
DLLEAELSRSQRSHCAPALLVLDLDHFKQVNDSHGHQMGDQVLQQFAQVVQGCLRRPDLL
GRFGGEEFLVLLPDTPQQAANIVAKRICAAVADACVSGESSGVRYTVSIGVATAEDGIGV
EQLLRRADEALYRAKARGRNRVELAA
>A0A1J5R0F6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLNSLMQGLWTWTHWGCDGVESLSVRRKIFHVNVAALIAIFSMALFAVPNVLTGNSALFK
TELAQIPFYFLILAVPRLNRHGHAGIARWLLSLSVTAAIATDIWVANGSWLDLHFYFMLF
ALLGVLFFPLRQWVSILFLFTVNASLFVYCGYFGVEPDPALLSLDTATATMFRAAYVSTS
LFTLLFITWLGEYVANKNERELEKLSGMDMLTQLPNRRRLEQRLMEKIAVSKRTGQRGAV
MFLDLDNFKPLNDTYGHAAGDMLLQEVAQRIRACIRETDMVARFGGDEFVILLSELGTEQ
EDAKWRANQVAEKIRVTLAEPYRIAVRAGQDATGQVEHRCTASIGVEMFAGGAMSEVDIL
KRADAAMYKAKESGRNAVSFHEEKQYAWDNPQLPTVA
>A0A1J5S619|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPRLGSTLDHLAFGAATFGEGQEFRRFQYRFTCAILLFSIIITAFLHLAVQAGLALLDPV
YARISQSYLLLSLVHYLILRGRPAGLMGVAASYAALSLGLHGCTLFFNTPDELRIIWFIL
NLPGVYLVLGQRVGIAVTVISLLFVLAVNGHLAAPYSPSAIFTFILGLSYLSALLHAFTA
RSISFHHAMVAANRRLAEMAARDPLTGLMNARAYYARCEAALKLAARTGTPFSILFIDLD
HFKQVNDRHGHEAGDIVLKSVAAALSRGLRDSDLLGRIGGEEFSALLPDTGQEGAAVLAE
KLRQEVEYLMPDIGGTCLRITASIGVASGDGQSGGVAAVQKQADEAMYRAKQAGRNRVTC
FALART
>A0A6N3GDH8|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MSDYILARVSETLTQDHSLETLVRQLLEMLEMVTEMESTYLTRIDTDGRYQHILYSRNSK
QLDIPEGFSLPWGDSLCKRALDDNRLFSDDVAHDWADCEAARAIGISSYLSTPVVLTDGS
LFGTLCAASTGQHTLTMRGQQVLRLFAGLIAQSIEKEKLVEQLREANAALIAHSYTDPLT
GLPNRRAVFEHLTALFDSARKVGYQVIIAFIDLDDFKAINDRLGHEAGDRFLIEVGQRLS
GSCQKDEIVGRIGGYEFLLACRGSAADNHSDAALTQRKHTLQHCLIGEYPLGPVKIFYPG
ASVGVVEINPADTDADSALHAADQAMYQEKHAKQKKRFVQLN
>A0A701W1K2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 58:a:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C5Y471|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MDKKKKLIQLTEGMLLCCVIVVMTLLCIGIIKKEVKNTKGKLTETTGWYRIQDNKKVQVD
LNQKIKADSQGKLVLYNDTIAQKYKGYLMTTKAAKYSVRIYAGEQLIYQYSDYNFHRNDQ
MKSKLSCDARIPEQGEKGTVIKIIYQNGSNGIYDLGDILVGRGDVVMGFHVQQEIVGIVM
IAIMFFLSFVALITGIYLKHFKLNSARFLNIAAFLALSGIWFLSDSALAQEYTSFPALTG
MISFYAFMLMSVPMVHFVKNTLDFEKYKVLDMINLLFYANALIQGILNKCLKIHMVQMLF
VTHVLLFVAVITIVVLMIKEYRRTKDSELKIIMNAFGIMAVAGVLSLCMYWKPEVPFYGT
IFEVGVLIFELLLLISIFVNLVEQAKTRSELEVYERLLKEDRMTGINNRTAFEEQLQDIE
DHAQDYDNVALIFMDVDGLKNINDFYGHNAGDELIISAAQCIKNVFAAYGKCYRIGGDEF
CVLIFDSIENMDELLKQMDHEIIKYNRNNRYYLSIARGVSFLKDTEGKQKKISDWKYEAD
QDMYCNKKRRNINDRL
>A0A448QHW0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSAMRDETDMRALQQLVTRRFALASVTYGLGLVLTWVAVAGGFYQASVASAVAQSALIVV
SQLLFFWLFHRGINLRSKDPSLTEPQVLVGLLWLTSFLFNLGSARGSLLVLYLLVLMFAV
FLPPKVFIRYAALAFVSFVSMAALDYYLQRPIETDVFLLQASVLLVTLIWMCLFAGHVYR
LRQRMRQRRFALQAHQDTLRGMMRQLEDLASTDELTGLYNRRRFLRIAEGDLNRLRKGHQ
SGLALIDLDHFKRINDIHGHATGDRVLQAFASVARSCLRDDDVLARYGGEEFVLLLPNTD
AEQFTACCERLREAFANAEPEDANIEAGHLSLSIGLTLLNAGDDLDAALQRADEALYRAK
RGGRNRCEPAWVTADA
>A0A1C6E618|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKKVRKLLGILIVGILVMFLCINYFSQIIISQNDMTNSSKVIFRQIDQIIKQNEEELEK
RKEDIRNICILRARATAYLLQRDKSKINNLEEMKKIANLLEVDEIHIFNKEGTIYAGTEP
KYYGLNMKTGEQISFFSPMLEDTSMSMCQEITANTAENKMMQYAATWTEDGDVIVQIGMK
PSSVLEKIEKNKVSYIFSRLAETNGYTLVAIEPETNKIVGSTKEALVNKNISDIGINTKK
MKNWDKAYHFRIKGKWYFCIFEKQDTIIVGRICEAKILYSNINENNFMFFIYILLIGGVV
IYFITHYLDKNIIKSISAINNGLQDISNGNLDTKIEVNNTPEFKELSHYINQMVESILET
TDKISVIIDTVGLPIGLYEYNGSMERVRITHKLPEVMGLSEEEAYKLCENREEFNAWISE
ILSNPIEGEHEIYKISSSPDRYVKIEIIKRDDSVFGIVVDKTSDICTKNKLEKELGEDEL
TGLCSRRGFYSKMDELFALPEKLGCAAVVMIDSDDLKKVNDTYGHNNGDRYLCEIANILL
KVNAPGQLTARLGGDEFAILFYGAGSKEEIDEYMNKLEELRMNHIMKMENDVVIDVKFSM
GKAFYIVDGVESERLMRVADKRMYIDKRERKKKQME
>A0A708RJC4|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLAD
>A0A2H6B617|diguanylate cyclase|EC 2.7.7.65|bacterium HR41|TrEMBL
MSVTFAIAMTFNDSVQIPGVNFWTTVSVVTLVAVFTRRITERAEALVEELDRAARTDPLT
GLPNRRRLQEELPDRIERARRSRLPLSLVIFDLDHFKRLNDRYGHDAGDEALRAFARLLR
AESRQGDLVARMGGEEFIAVLQGAGAASARRFAERIGELLREREIADGISVTTSAGVATF
DRDATDAESLLIAADRALYAAKTAGRDRVVAAGDPSVRPLSVR
>A0A1C3HA58|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MGEAMNVRINARHGLPLTVQLINLFMLAFLLSLVGILSRPIGSLSLFWPVNAILLGLLLR
KPVYATPLGWLTTYLGMVAADLSTGEGWSLALWLNACNMSLIAVGYGIMLMLPQSQRRMG
KPQAILYMFSASLAGAAVASTLSVLRNDSLYNNTVVVAWLAWFSEQFSTTLLLLPVLMAA
PRLKQLLRIQVRWRLKGCLPLLALLLSLIFSVYIGGPGAIAFPIPALLWCAVRYQLFPVT
LLTLLTGMTEISSISANLVLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAANRK
LMRRLEHSANHDFLTGVLARSAMTRKAGELLEHKHRSKEAVSLLLIDIDHFKQINDTHGH
SAGDQVLASFAHVVRRELRHDQLFGRLGGEEFAIMLPRALAAQGVALGEHLRRLVEQTEL
QAEGKQTLKITISVGVASLAMNEVKSLEQLMNMADIALYRAKSQGRNRVESFNVVNGNSV
EHILFR
>A0A8F9N1H0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A1E3AP31|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MMENDKNNKSSLPEARLMQQILKARHTDLEEEKRLCKELLSVSEAEQYYYGSAFANVYLM
DSQLSMGEYTSCDFYLLRAVFLCREYGYDDLMLVLCNNAGLYYQKLNDDQTALSYLLEGK
KLAEKLGDITMLGKLYNNIGYSFGGRDDWESAGVYFRLAYRTVEDHLDEENKRSSISYLS
NIAEACRNLGDLEGARKAMERCEELGADSAYSRVRLGVSWCSYYAMCEDWDKFTEMADRL
INSDLLAVEDHFFICDMAESLCTEMLAACDEKRADRLLAIMDNLEYDNSLSLKYRIQCLK
IRCWEQFGETDKLDQAYRDYYEIVKDVSAVEDDMRIQSMLSKIQINQAMHEHEEMVRNKR
ALENASQLDELTGLYNRRYFNKLLSKMTHKEDGKKLGFIMLDVDYFKPYNDFYGHFKGDD
ALKSVARVLKDNQMDGMYVSRYGGDEFVCLCMDLEDRDIEEYIKRVGRDMEAVAIPHEKS
PGPKVLTVSMGYCNEIYRKGMDWEPVLNRADRELYSIKKKKRARIKN
>A0A150HVL2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter venetianus|TrEMBL
MSQANLALKPHSFFQLFALFTGVILLCCLLGIATRHLTFLASFWPANSVFLGLLIRFPQT
RHPISFVGAAVGYLLADALQGTPFLLNLCLNSANLVYVITTLTLYIKFNSYIRSMHQGYF
YLTLFSFCCIGGLASSLFAASTLPYMNTQFSLGSFWIDFGYWFTAEIQNALLLLPAIISA
PRFSEFKQQLIEFKTQTVQESLPLFAVIFSIAVGYYDNGPGSLLYPIAALIWCALRYRHF
SVAIITSISCAFVIYHVSQNYLLLYPEQYLNNTISIRLGLIMMTIAPLTVSSINMVRSKL
IQELQHTIAHDELTSSLTRRQFLQSVQLLQHQASNASQTTAFLMLDIDHFKQVNDNYGHQ
AGDLALQSCVQNIQALLAPNDLLGRLGGEEFAIFIADTNPEVVYQCAERIRQQVSNTPIQ
LDKKQQFSIQLSIGICICTPENQHSIEQLFKQADDALYQAKRQGRNQVVFST
>A0A1Y6MD80|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MQEEHANLLSGLYAALDHVHSFVYIKNQKLEYVYANIHTLKLFECTAEELYFATDSKFFP
SDVVNELRAVDLKVLSGESTEEEIIVNGETSKRRIYLNVKTPIYSNTTPHEIIGILGIST
DITTQKSLEEKALRLAKTDVLTGLANRLELDARLNHEIERYKRFKYPLSVILADLDHFKN
VNDNYGHLLGDKCLVQVSDILNDCSRVVDTVGRWGGEEFLILCPETDLDGAITLAEACRM
TIAQHYFPEVKHVTISLGVTTFIAGDTLEMLINRADQALYHAKTNGRNRVEALIG
>A0A1E7WZK0|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MSIASQHNLSAIWSTGQSGDFAILQLVPDGVLAVPAGLSLPEWIATVHAGDCAQQLAAVV
AALAKRAPFDIELPLRCLDGAVRQVRVSGMPAAPGTCQGFITDLTAHYQALAAVRHQADE
YRLLIENTTDLIAHCDTDGNYLSISPSYESMMGWDPARVVGQPVVEFLHPDDRPHSVQAL
SHVLGGGVVPHVVEVRKRHRDGHYIALGTKASAIIEPATGLCVGAVMVSRDITRDQEMLR
EYEERATRDALTGLPNRAWLLQHVDRLLADSTADTITAILFMDLNGFKEVNDTMGHAAGD
LLLQLVSARLKHCMRSGDAVARLGGDEFVVAAACHDRAEAGAIAQRLIDALQAPFQLDDT
PVQVGAAIGISLASSGAATTASLLHDADSAMYASKARGDGSFQIFTP
>A0A090NDI2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRTLKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQLG
LFDEIQPRKNSEKLMKTLDELNQSGKGTVWFTGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A6N3QGT8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVITSSLMMSLT
VDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEAHSAIVILDS
RGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSGNAYEVELWI
PTCKGQRLFLFRNKFVHSGSGKSEIFLICSGTDITEERRAQERLRILANTDSITGLPNRN
AMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQV
LARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSD
STAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPK
ITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVAKWRDK
GINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQ
FSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQA
LNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRA
>A0A6N3QEI0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGWWIYQIWNASVN
>A0A250VU28|diguanylate cyclase|EC 2.7.7.65|Streptomyces olivochromogenes|TrEMBL
MNSPDTVLVVEDDAGIRDLMASALHFAGFDVQLAEDVPQALTRLAQHTPDVIVLDVGLPG
GDGFEVLQLIRSRGVTVPVLFLTSRDAVEDRVRGFQLGGDDYVTKPFSVIEVTARLQALI
RRSRGSAGTAADDGILRYADLELDDKRHTVHRGGDTVDLSPTEFRLLRYLLSHPGHVMTR
SQILEAVWQYDFGGDSVVVERFVSNLRRKLDHGREPLIHTVRGIGYSLRRPAS
>A0A0U0YHE5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQ
FSDTGPRSMIGRVIVGLCAVGSLGWALRWVVGPWPSLREAVAFVAFADIGIAVACWQDSD
PLAGLVGTVLFTPVGAYVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVK
VTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPL
DGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLVDVAHALTCGTTGTSVVGRSGGEEFLVV
TVCPASAVAEFATRLREAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACAD
RAMYEAKHDGGDQSRILHADHDSEGRYLWRSGA
>A0A0J6VMC0|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chubuense|TrEMBL
MRRLRRSAEHHLWLSEYLVARGVARRTRLWLAVTSAAMAAGVLILLFGAGGPQEADERAL
MWVAFAGGMFGTALWLWRWPTHAMSLAFVAVTTVSITAACLAYPDPLAALLGCIAFTTIV
GYAAFFHSPEVVAGVLLVVAAVAVDQAAGLAAQGRLALAAVDLFLILQCSICVALALYSL
VRTLRGDLAAADLDPLTGLLNRRAFRRTVGGRLSNHQGKGGYLLTALLDLDDFKAINDTH
GHAAGDQALVAVAEALRATATPSAVIARSGGEEFLFADFASAHDVVARYEELCAVIAGLP
VSVTASIGTSFADLAALTPRSHNDLLDRLIVAADQAMYNAKRQGGNRCHHYGSVH
>A0A1I6BCK5|diguanylate cyclase|EC 2.7.7.65|Halopseudomonas formosensis|TrEMBL
MPATQFTLDDLTCEWLERLDSFPADVRERVAQTAERHRTDLASHFYGVMLAHKEAAQFLS
HEEVKTRLSRSMENWITNLYNSSEAADIQSVIAHQTRIGEVHARVSIPVHLVLRGARLLK
QRLITYLREELPERQAAEAAAFAATLIDLAMEIMSHAYTTSHDRRSRAEESYRLFAVTQN
MASEKERQRAALLDWENQLMFDVAMNTAAQHLPRLSASEFGLWFRHKGAHGFEGAPETEL
ILESMTRIDEMLLPLFANRQSEANPTHTMQLLRDLREQAKSISYHLDLLFEQNNELESGR
DVLTRLLNRKYLSVVLNKQITYARSTGGSFAVLALDLDHFKQINDSHGHEAGDLVLQQVA
VLMLNRSRAGDYLFRTGGEEFLMIMVDVNDHSAAKAADNIRRAIAAETFRLPQDVTMHLT
VSLGLAVYNGHPDYQQLLRRADDALYEAKNNGRNRVVIAPE
>A0A8B4S9C8|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MKNSLAEGLDFEDMFNLAPVSLWMEDYSGLKQIFDQWRAQGVSDLLSFLKEDPERLKLCS
QSYKVLRVNQYTLDLFKAADEETLKSRLSEVFRGDMLDSIMNELLALWEGVLSFETRSVN
YALDGRRLDVQVRARVLPGYEQSWSRVLVSLEDVTAEVQSTVKLQSSEQYSRDLFEYSPV
SLWVEDFSVVKRLMDDVRARGITDFRTFLKVHPEFVTRCMQEIQVLDVNRQTLQMFGAES
KQQLLQNLSKVFRGEMYDSFAEQLIDLWEGKLVQQREVVNYGLSGDVLHIHMEFAIMSSH
AEKWGLVLLSLVDITARKKAEAYLEYLGKHDVLTQLRNRAFYTEELNRLSRKGPWPLSML
AIDMNGLKVVNDEHGHTAGDAMLRRMGEVLSKAVDAPACAARIGGDEFVVLLPGTDERGA
VALQERILSLLELNNQFYPGHSIQVSMGHACGQEGTPIESIVQGADKAMYAEKARLYRDK
ERDRRVSST
>A0A8B4S526|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MDSPGTSVAPDLFEAENQALLTARAAHTGCACTAPSQCRQALGDLLLAYERLLRETRRLV
RRSDRAELEMNQLNSRLQDLAAELEHRATHDTLTGVLNRAAVIELVNQYFVHDDLSLIVL
DIDHFKRINDSFGHPTGDKVILGVVACLQAVVPSSAQIGRVGGEEFTVVLPRQSADVSER
LAQDLRRAIEICDFGLPDGSAVTASFGVSWAPPGGDFDSAYGFADEALYVAKRGGRNQVC
LSSCFLQSLEHET
>A0A8B4S6Q2|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MVEVTDLESAYLTTVDETRGIQNVLYSLNTGGMRIPEGLEVPWNDTLCKRSLDEGRTFTD
NVGECWGDSDAARQLGIQTYVSTPVRFSNGALFGTLCAASDHSVALAAEAEDLLRLFAKI
IAGFAEREQLVRSLQHANEELASLAMLDALTGLPNRRCVTEELNRLIAHCRRTREWVLVG
FVDLDRFKQINDQFGHEAGDALLRAMAEQLRAGLRSSDMLARFGGDEFVMVGAGPLLDED
AEAVIREMQLRLSKASVAILQLADGREIEYAGASVGMVCLTPDDTDVDDALQKADAAMYK
VKAARQRLPEVI
>A0A7L6CN31|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00994|TrEMBL
MNKDFTSTPRPTFKRTLRRISMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVLDTHKKRFAYWSWNPEENTDTLGALVS
RWLFPTPVSQPVLHNGNTIGEIRLTARDSLIGHFIWMSFAVLTGCILFASVVALTITRSL
HHGMVTAIQNITDVVHDVRTNRNFSRRVKEGRIEEFHRFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDSSAKVNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMILYGVHSELEVHNICIALSQQFIRPFDL
HNGHTASMSLSIGSALAWENASVEALLEQADRNMYLVKNQSSKTIS
>A0A8J8B2L5|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MGNFVYIPIIALLCYTFLFLAFIAAKKNDIINAFLMILAALILWTGGSFCMRMQLWPSIK
FWYDASILGLTLLPYAFFRFVYEFVGASGTFSKRLWLLLVIVTNAINISTGAFLRAPEVV
FAGNGEVSFVYHTTWLVSVMFGVCAVIVLHMLFLLFKYSKTNDMTRKQFTPIISGIIILF
IGHIIIMIPYFRGFPADILSGIFNAFFMFYALYKRRLFKLTLLVSRGSCYVIAAGLSFAI
FFNLIRPLERFINVNFTIFADHIVLIIAFIFTIATFLIYYIMKRFIDRVFIREEIVQAEN
LKEFGFAVTRSLNVNEIMQELVDVIQKTISVKRVYICVLDVHSNCYEVAHSTSLLDVKSF
RINKDNPIALWLANNNECLLMKDFRRTVDYKSMWETEKKQIADIDIECFVPLKDEDGMVG
IVLLSGKEKGGHYSFNDISFLDSVNSIGSIAVKNSRLYEKAYLEARTDELTGLLNRKYFY
EVIQTEYEKHKNNSLALVILNIDDFKLYNQLYGNKEGDIALQNIARIIQATVGNNGYVAR
YSGKEFAVILPLYDMLAAKNLAETIRKQILNMNKRESDYSLKMLTVSGGVCSIPYAANNV
KQLIDNADMAIYNVKRNGKNAIMVYSAGEHHVTADEKELSEHKADIYSEYAPTIYALTAA
IDTKDHYTFNHSKSVAYYATELAYAYGMNSDCVEIIREAALLHDIGKIGIPEQILNKPGK
LTPEEYEIMKGHVENSIGIIRHLPSLDYVIPAVIHHHERYDGNGYPRRIAREDIPVSARI
LCIADSFDAMISMRSYKEPYSVATALKIIEEQAGLQFDPKLAFMFIELVNNGTIRIGEEE
A
>A0A8F8CDV2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AO-1|TrEMBL
MSDDAQRWKEKYLKSIEQQDKLERRWAARLDLLRRGLVRSTLAAEGTDKVVDQCMKEMRD
VVRTDDMDAGLAALLPRLEKAVLDSEQRRETRIDQVSTALTALVTQLQALPLPREVAQPL
KKFAKQLDSRVGQAREMPLLLSELSGLQGKALSQLETPPAPERPGLLQRLFGNRETEETP
GTQGPEQAQAPAPIPAPPSVNTEPDVEPAQTPTGEPTPAPVSAAPLLQPPEAGPQQAPAA
QPQAESPVLSFVPPVIAIETVPEPLPELKPPLEPLALPLAPPALTAAINPDELIHPGDAP
APLLLDSLPLPAPIAQALAAIDPEQPEQDILYALPDSPEPSYSSVAKHIEDTLIGLLDDL
TLPERHRPQAEAMRDRLKNGLNWYELLPILDDLATLMLAITDSGQHEFEAYLQRLNERLE
AFQSNLQAASEGHADNSSAARAMDTQIREQVDGLQTSVQEAADLDDLKRVLENHLEGLLG
TMDQHQQQRDAREQEVAARLKGLAERVAHMEQEALGFREHLEEQRQKALIDPLTGLPNRA
AWSERLEHEIRQWQQHGNTLSLAMLDLDHFKRINDNYGHLAGDKVLKIIATVLRKRLRGA
DFIARFGGEEFVLLLPATTPAVGAKLLETLRAAIEACPFHFKGERVTITISMGLASFKPG
EHSDLVLKRADQALYRAKNGGRNRVELG
>A0A8F6N3J8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes aquatilis|TrEMBL
MDQALEKNRAYALKLASSTDAFITNLQQQLRYSANLLSGPAPKTEQQLNAEVNRLHEQNN
SFNSVLILDTKGQVLANAPYNLGLLGTVLHGEGTRHALNSKIPLVSSPYMSATGRLLIFL
SYPILDVDGNYQGLVGGSIYLHEPNSLNALLGEHFHRDGSYIYVVDKNKRLLYHQDTSRI
GEIISDNPAIDAVNQGRIDALALENSKGTDMLTGFAPSKDVQWGLVVQSPTDTVLKELSG
LLGKVLRNSIPFFVAVQILIWMLAMLIAKPLRQLARQAPHLDTDLAGSRISQVHAWYFES
RQIKLAMLLGLKRVNRKMGVMDIERNTDPLTSLTNRRGMNAMLQQWRDTDTPFSVLAVDI
DHFKRVNDTYGHDVGDLVLCFLANTMRACTRDTDLVCRVGGEEFSIFLPEQDIDQAVQLA
ERLRILISKTNSPTGSPITISIGVANWPIHAREHSTVLKLADEALYTAKRNGRNRVEISS
QNDQVREMPPPL
>A0A857JKM7|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MKNHDLENSFKHLKNTIPLLLKHKIPAVPINYALWYTYASKESESLNETLDDALQRNLPI
SDSKTKDLYRKYVADEQDIDTWDLRHSLESMVIELSQSVQDTRSETRNFKSTMDTCMDDL
AKVEREGLSMEEVMDLVRTLVSQTKQIRGSTLSFSTALNDAEKEISRLKNQLEQSQQAAL
YDALTGLCNRRYFDEELAVNAMQPNMCLILVDLDNFKTINDTHGHVMGDLVLKASAKKLQ
AACRDGAQAFRFGGEEFAIIVPNSKLSVARQIAETMRRAIEKIGVRDKRTSEVLGGISAS
FGVAEMKKGMNPLALIQAADKQLYDAKNLGRNRVMPMATS
>A0A379IWY7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MVPPSHSNTIDFDAAKLQRLGFTGNRNLPLKPTSLVGLRHQLSLQLQTSLDAERILNLFY
REVQRLVPLDALAFQHPSYDLRMELGERAPHSAGYRLSHEGEYLGELIFRRKQRFAEDEL
IQLESLLASLLFPLRNALLYRTALQSALRDPLTDTGNRIAMDQVLQREVDLARRNLQPLS
LLMLDIDHFKTINDNHGHALGDEVLKAVAQTLKNQLRNVDMVFRYGGEEFLVILSGTSRD
GAALVGERLRFAVLELQCLDAGRPIDVSISLGCASLLPGESAESLLRRADNALYVAKREG
RNRLSMAG
>A0A5E4T5I8|diguanylate cyclase|EC 2.7.7.65|Pandoraea capi|TrEMBL
MSHNAVSVMPESHTLLEIVKTQTEIAKLGLDLGGVMSFVTERVQDLNA
>A0A7W5HK15|diguanylate cyclase|EC 2.7.7.65|Halomonas stenophila|TrEMBL
MDEHRPHASRLFPVVLAVATLLLLGQALWFYLMGDYGRILLPALLSPVMLVATLLAAGAH
TPSRASAYLVLICGFLLTAVELPRQAGLPALWVGLPPVLALLLLPLGPAMLLNLALTPIW
LALLGNGEPERDLLLVYLALVAVAALVPWERLRQQALLRATDPWERECRAVTRDSLHERL
AGEFERAEFLERPLAVLLIYLPQVDMAGEQFGAKARTALLEGLCRGVISRCREHDVLGRE
GDAAFWLLLPDTTESGALLVRHRLTQALSQVVLVETGPLQLRTRLAFPRPDETWPHFEQR
LQALSHGLADG
>A0A3S4WQE5|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MSVSRMRDIPRKWLLRLALLCLVLSGLALVLYYTYLSIRHDMQLITAKQQNVFEVYYQRA
RILEPEHLAQFVDGSSIKAPIFSENQDATVYVYGYDVKFRDRIAVIPILPPTSEMLIAYQ
YALSYPDVINLYAFYDDYRLLGMVADKQILPRRLLPSNTRLDDLKPWRHYFGCAAFASTH
VPCSADEAQVSEIYTDAFTQLQTITMYFPFVFYDQAKRDYRYGLSGIDIDIHEAFKAVFR
PFETLNPSRTVISFDAAEPCRSWHLCLSTRLMQTKAGADLYLKWSYGYGDFVRVALYGPA
FKLYLIALLLLMLTGRRAYARLRTLAYTDHLTRLPRRDILDNALLQEHDYLMILDIDNFK
SVNDIHGHAVGDIALAAFARHLQENIRKGDCAIRWGGEEFIALYKGLEDEAAMRHAVARL
LEQELRLPQLPGPITFSAGIIRIRDYLTVSDAITLADELLYHVKQHGKHNIAHYQGQHIE
LIRTPESPTG
>A0A0A6ZSD6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MAMIKKTMEIDVILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWI
DHLGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALT
DYKIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGH
LIGDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAI
SHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7W3A124|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RHBSTW-00465|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVKAVLKNIADQQAEALATRFYDFIFQDPDIARHL
TYDLVQERLSSSLAGWVRDILMSEKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSEIDRDTSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKTDINGALLSESEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDVLLSAWKSSADDSEYKNTQSLLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGAETEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKMHEGDGN
>A0A2G4AZ81|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MRFSLFFIVMCWSVFASAQAKDVLVIHSYHQGFFWTDDFHKGLAEELDRDGLSYRVVYLD
TKRTQNAEYLERIYQLYRTKLSHEEFAAVVVSDNNALNLMKRLAPELNGTPVIFGGINNF
SPQMIEGLHATGITEDIDMASNIELINRLQSTVKKVYVVTDHSVTGEAIRAQVELFLQKR
PEFSGLVEQYTPDSYQELMTFAQRADLTKSLLFWAYYRDINGRVSSKEDWRQLNKKTQMP
LYIVHDLGLGFGAIGGVIHSGETQGRDTGRVLLNVLANPDKPLPQVVAGAPEIKLDYQQI
SRWDLGAENEAAVTFLNKPKSFLVRYRDEIRTIGLLFLVMSCVIATLVYYLNRLKKSERT
SRQSQLLLESIFDQSLQFMGIIDKGGVLLSSNSKLHELLYNQGYKLGTPLQSLQHWEDSA
RQELKEYFISSDEHQILRFEAEVWCRDRGAMVLDISLKPMPGSEEDDVQFLFEARDVTSG
KLAENKLFQREANLKLYYDKQPVMMITLDGNNRIQQVNQFAEQLLGYPLDQLLGHRPREF
YVDGNSMIPRHILLQPQHKIRGVWRRDIEYRHANGSTIWIRENIRPLVESDQLLIVGEDI
TETRELSEKLEYQARYDLLTDTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLN
DTAGHEAGDAAIMFSAKLLEEVLPYNAVLARMGGDEFAVLMKDCTERDAVNVCRSIISTM
SENPFLWGDIRLNLTSSIGIRLIDHTAASPQMVHAQADAACHAAKEEGRNRYNLYHQDDE
DLRRRHLEMECVNLVHEALANDRLELFAQRILGLDKNSEKMHFEILVRIKNIQGEYISPG
IFMPASERYNIAHLIDRRVVSQTLAWLEHRPKVIDELGMCSINLSGHSMGNREFVEFLIE
SLRDSSIPCHKICLEITETAAMSNMKQAIKFFTRIKELGCMIALDDFGSGLSSFGYLKKL
PVDIVKIDGLFVRDIAVNEMDHVMVRSINDLAKQMGKHTVAEFVENTQIIDKLIELGVNY
AQGYIIGRPKPLAELIEELQKERTLEYLD
>A0A4P8C2R5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:NM|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B3WCS6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MESNQLFFRTIVNASYDIVDTTVNEAIKTYLKGITDTVASHVWHATPEQEIEQVSQIANE
LHIGQSGYIYLMSPQGVHLYHPFLQGKKRGHLTHIQKQLSIDSGMIEYFHANPHEISRRA
KVAYSMRLPSGNTLVATTYKEELMYLVDLEGLKDKLRKYAFGDSGYVYIIDLQGNLVLHP
DYEHKSLKALIGYSSELLIDRIATQPEGHFSYSISSDNGTTNKNVFYKFYPYLNWVISAG
ILEQELNRNHSLLFISLMALVVSLLSIIIVLVLYLRHRHLKILDVASLDYLTGLPSRRSF
IEQLKLKIAQRSPYPLTNVGVVLLDIDHFKRVNDQYGHAQGDRVICEVAKSLKRFVNRRR
LIARYGGEEFILVTFDCDERELFELSEELRRSVEQLQGLVSPVTISAGCCHDRALTDIET
AIDKADKALYQAKERGRNNTQTYQKNEYRVAYM
>A0A0H3ML60|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O7:K1 (strain IAI39 / ExPEC)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8B3WAA3|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPSGSSKQWSAKVVSFLFFLAIVSAIEFFHAKQLTFLKNESYSEGKKQLSIIRSRIEAAI
VSDMYILNNFSTLVTINPDGEVKNWDKIAENIIQDGFHIRLIGLAKDDILNFVYPMEGNE
QILGINYRDYPNQWESVEIARNLGNTFIAGPFELFQGGQALITRTPIFRDPPFNQNYWGV
SSAVIGLDELFEDVGIGKIENKYELAIRGANSSGKDGPVFYGTQDVFDNTFATEQVSFPY
GGWYLALSGSEHVLMDVPWYRVQAVRLVGYSIMLVLAIAFMTIYRLYLIADSRSMHDELT
MLPNRRYFMYSLKQAFKTTQKQRARTFAVVNIDLDGFKAINDTFGHAAGDQVLVECAKRI
KSELRGSDIVARIGGDEFLVLLPRIIDDQHVSSIVAKLRKVICTTPVVYETHSIYLRISV
GWVIHNNNYDDVDALLKAADEKMYEQKRQVM
>F5NW26|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A7U7G8X9|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MWLSKVVARTWPLRRWLALRFVLVAALPLIAVAGLVWLVLAPQLRTDIEHRHQVLARAVA
GQVETYLTGAQRQLGAVADLVRGLGYRPTPYWFGLLDAHVSTGASFEAIYLVDAADSVHS
VGLPESQRGRREDLIGLDLSQRDFLRQARAHHTAIWSETFLSAVTGRLAVALAVPVMEQV
IIGEIAIEPLSAFIDRLPGESGRLTLLDHHGQIVADSRQALSGQQLNLSYLPIVSDALRG
HFAIHNFEFGNEAVIGTTVEVPQTGWIVLVTQPRRQALQQIVITLWVMAVGAGIALLLAI
AAGWTLARDFSRRFDRYTDLAHAVAHGDYDRSCPPSHIAEFTDLANDLQRMSLAIREREQ
ALVTSETRFRDLSTMASDWFWEQDEQFRFTSFSSGLAQAHLIFAEMLGKTRWELSTSLRS
EQWAVHRAVLEAHQPFRDFEYCYTDPSGEHWINVNGQPLFNETGHFVGYRGTGRDITERK
RMEEELASRIIALTRPLDEGDGIEFAELFNLEDIQTLQDLFAQATGVASIITHTDGVPIT
RPSNFRRLCDSLIRCTAKGLKNCYQSDAIIGRNNPAGPTVQPCLSGGLWDAGASITVGGR
HIANWLIGQVRDQTQDDKKMLEYAREIGIDEKDFLAAFNEVPTMPREQFERVAQALFALA
KQLSTLAYQNVQQARFITERQRTEQRIEHLAYYDALTNLPNRMLLAQRAELALAMAARQR
TGLAVLFLDLDRFKDVNDSLGHAEGDALLIQVAARLQEQTRETDTVCRLGGDEFVLLLPD
TNQEGALQVADKVLMAFRQPFPLAGHHLRVTVSVGIALYPHDGQNVNDLLKNADAALYQA
KQDGRNTRSFYASEMNVATFERLVLESELRKAIAAGQLRAYYQLKIRLSDSQVVGAEALV
RWLHPDHGLIPPGRFIPLAEASDLIVELGDWMLEEVCRQLAAWRSVRLLPLTIAVNLAAR
HFRDAGLVVRIQGLLTAHNLPPQTLELELTESSLLEAGPQTVETLLALERLGVGLAIDDF
GTGYSSLSYLKRLPLTALKIDQSFVRDLVTDSDDRILAATIVALGHSLGLKVVAEGVETD
EQRRILLDQGCDLAQGYFFGRPVPAEEFSAGLRREGTFGTD
>A0A7U7J2H9|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MQSPPDAVPTSGFPAGEKPGFSRRWEPEQRRWLAVWIVYFVLWYAAWFGSVALGAFGNSI
SLWYPPAGLRFFALLTFGWRAVLPVLLTEGSLGVLLWATGPSPFPLMPAALGNYLEATLS
PVGCYLLAALALRTWNVGRTNNNFADQTHTGRFLSMALLGGVLAAGVGAARLLRTDFIAS
SQFPEAWFYWLVGDFIGVITLTPLMLVHLSPRLRDWLQWGRWRQPFPQAQRKPWWLWPAY
LAGLLLTLVILFKLPLWLGLGGPRPFPTLFILLPLAWIAIAGGLSVSTLAIFALDAGLAF
LVAWHRYQDVALYYQLVMIAVALMGLLLGGVTEARDRAFDLYRDLSRVSNDLLWDTNEDG
RLTQLNGELAWELAPSLGRWWRTGIRAIPVECRKMLSAAIQARRPFREVMLSVCNHAGEL
RWLRVNGLPYRDDLGRFAGYRGAATDVTSQYQAERLLAGYTQVLQREVSAKTTELQRINR
DLVFSEQRYRTMLAAAPVGVAEVDAAGRCQYVNFPWCVLTGQAATAVLGHSWLEGIHPSQ
RSEAEQLMETRQNRRTGDGEFQGLADQWLSVHWSTLYDGDGAITGAIVILNDITDRRLRE
QENWELAHFDALTQLPNRILFWDRLEYALRLASRNRQLVALLWLDLDGFKAINDTLGHAA
GDELLRQVSQRLQASLRESDTAARMGGDEFTVVLATVAHPEDAIGVAQKIIDQIHQPFTL
PQGLAQVSTSIGVALYPDHASTAKELVHCADLAMYAAKNAGKNGWRLWDGDAEADRAEP
>A0A377ITN3|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MYFTLIMIIIGIFFLLGGAIVVWPLIKKASYYHYQWIANLVLICFFIGSFLFVIVYTLLI
NEFFTNYFYATLFLLGGFYVFWMSYLSSKTIEKIKTMDNLKLEYEKIRYNAEHDKLTGCF
NRHYLMEILDNRFRKIKLNTGQLTVMFVDLDGFKKINDEYGHDFGDQILQRFGQLLKQQL
REEDIIARYGGDEFVVLVENIPLTKAKSIGQKIIQTTSRITKEKLPNHSSLGCSVGITQL
TKNSLSINSVLKKADDACYKAKKNHGNTIWVDDNMTSSFLD
>A0A2G4B1N6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MKVNRHFSLTFVFGFPAVIAAMLLGLIGKNHFDAVEKDISSEFNRIEDVFKGTTKVVTAL
DYSFSNYYKSGNPLFLDHNKQVVDGLCRIWPIDSLLLADGKTTDIPSVDIDYMLVGEESL
CTETSGTYKSASEKIALAPILSFLSQLDEFHNGVHFIDKRGYVISSPEDFAKGLGKELLS
TIKSRPYWQRTANNPDLLTLSGPAYRFDSLDRIISMTIPVFHQGVHQGMLSVDIDADRLL
ASSNEHLAGRIDIIDTTLANPIDTATFYHEIKLEGVASHHAMYYELDLANEVEHFFVYEK
DSLIVAIIVYLFSVTIFFYVNSNIERGYFKELAAKDPMTGLLNRRGLEAFWRSVEHDQLF
ALTVFDIDDFKSINDTHGHDKGDDVIRYMSRQISNSVRSSDVAARFGGEEFVVYMKGDDR
ETLIRTLERVKNAVCANSADIVPNGFTVSGGVCIVETEQNKLNFEEIFKYADEKLYVAKT
TGKDRIVF
>A0A377GDP9|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MIPPDKPEDETARLATLYKLHILDTEKEERFDRVTRIACKLFGVPISAISFLETERQWMK
STQGFDIKEAPRKTSFCGHALLSDEIMIVEDATKDKRFYDNPFVLGEPHFRFYLGCPLKV
KGHNVGVICLIDDKPKSKKEVDQNMVYDLAKMVETDLEQFQISLTDELTGLSNRRGFLKL
ANYLFKKCQREKQIFTLLFFDLDKFKYINDHFGHAEGDKVLKAFANALLHNFRYSDVIAR
LGGDEFCVFCSGLNQENVANIIERLDNSLKSVETKGYKIEFSVGSIQYNHKEHQTLEDML
ALADSKMYCSKKGKQA
>A0A379HBL5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MSADLNMNEIHWLMDMFNTVDVGLVVLDREYKVCVWNGFMENHSGLLPSAVKHKDLFDLF
PAIDEKWFRSKSESVFVLKNRSFTIWEQQPYIFRFKNYRPITGKADYMYQNATFIPLTNT
RGDVEHICIIIYDVTDVAVNKKELEQLNKKLEQVSQTDSLTQLANRGHWEHTLRQEFLRT
KRSGGCSTLLMFDIDHFKKVNDEYGHSCGDEALRHIAKLLKGTLRETDIAGRYGGEEFAI
TLLDTDKQGAMIIAERLRELIAATPVAYKDQLVSMTVSIGIASYSNEFKNHERWIEAADK
ALYNSKHNGRNSITMFDDIKNDA
>A0A550ABP1|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MFREELIQHTPRDVERLQKRIARLKSLALKYKRAEVTQNLLLEISNLAAHVNTPKAFFSE
VHRSLNLLIPADNFFVALLNPSSQNLEIPFFLDEKDPHPDLLYSKENTSRTLLSGLTGYV
LKTGEALLCDEAIFDKLIADKEIVSRGAPCHLWLGIPIRVNNTVSGALVVQSYSSDINFS
EMEIELLHFVSYQISGLLERLQHQEQLELAIEQRTKELSIAYDKLKSEVFERRRAERLQK
SLFEIADLATSNISSQQFYSELHRVISHLLPANNCYIALLDDRLTRISFPFYVTQDDTSQ
PQARMTCDGLTEYVIKNRRPILLQRNDLDSLIASGLVYAKTPELNYTREISQWIGIPLFI
HGQVKGILAIYSLCMSQSYQEKDLELLTFVSQHIATAIERKLSAESLRSSYELLEEKVVI
RTKALALLNHDLEKEVAQRRKVEQQLVYDANHDSLTQLPNRAMFMDRLTQAVKHIRRHGL
ERFGLLFIDLDRFKLINDTLGHLEGDRFLIETSKRLQTCIRDNDTLGRIGGDEFVILLDS
INGTSDAKEVAERVLTELAKPYKLANQSFNSGASIGIAFSNNHKSDTAESLLRDADLAMY
QAKSKGKGCYVIFDEKSHKKLVKDIELELELRGAIANHQLELSYVPIQNLDQQATVALEP
RLYWNHPMLGKVKQAQLNNIAEHCNLITELDIYLLEKLNIEHQLLSAHSLEHLPLHLNIS
AAHLKHKHAVRQLKNKLKQSIFPTEQLWLFFDEKGFILDTDNHINAFDTLKSIDVKLGLT
GYGSAHSALSSLTFLPLQGLKLDPSYANHLESEQHLKLLTAHYLTAQALELSVFVDGIRT
AQQKKVMQQIGFSLGQGQALGEVIRLTQTTNNNDVACA
>A0A383RQZ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MSKYGVRAKVFGLFSEALSAWAVALVALVAGALLTAALAIAAQTFYKQQLRQRFELLASE
RYSRIAERFDDQEQRLDGLRRFFSYSTEITGREFDGYVKPLLHRTQAYSWAPRVTAAQRE
AFERQASGVLGQPYQIRDQDMQGVLQPATPRDHYYPVLYSQAASQPGQPYGLDMLGQALR
QTTLQRAGAPGSMAVSAPLDMLNVEPAYARGLLMVAPVFAEGAGHAAPSGFVMALLSMRQ
LIAEGLPAAVDDNLSVRILDTSGSNGQEVLYDSQSPIAPIPMVSNHLLHLADHHYQLAIR
PSQAFLQANRSSAAQGVVWLGGLLSLLLSALLYSLFSQRQRALKLVEQRTAELRVSEQSL
RGTHNQLRSVLDAATQVAIIATSLKGVISTFNAGAERMLGYSASEVMGCLDLAELVQTDE
LSQRAHALSVRYGRDIAGGQALFAETVREAGGEPGEWTLVRKDGSQLFANMLVTAVLDEQ
GLWVGYLAICIDVTERRRVHEALAARDQLLEKLSAEVPGGIYQYCLYADGRSCFPYASQG
LYEIYEVDLQLLREDATRVFERIHPDDLERVRRSVRYSAEHLSPWREEYRVILPRAGLRW
VRGEATPEIGEDGCTLWHGYLTDVSDPKSVEEELRTLSITDVLTGIHNRRYFQERLKSEL
ERAQRDGLELAVIMLDIDHFKRINDEFGHAVGDHVLRSLCQHIGQRLRRSDVFCRLGGEE
FMVLCPGSDAEQARSLALELWQGVRGLSIAGVGRVTASFGVAGWRPGEGADSLLLRADAG
VYAAKQAGRDRVEVELP
>A0A549ZTF5|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MKNNSSKKASSNLVSELIQPDLLSFLSNNSPVLQLMIDTLPVPIFYKDIAGVYLGCNKAF
EEFIKLTRKQLIGRSVYELFDKELADVYQQADQALFDSPGNQVYEKQIKSLQGDDLFVKF
HKTSFMDTDGNVAGLIGVIFDITEQKRLEAVLTKHATLDDLTGLYNRREGLRQGEIHHKI
ASRGGSQLAVFMLDVDYFKQVNDRYGHIVGDKALQFIAKKLLSTSRMNDVLIRYGGEEFL
IIVSGTSEGDAAVLAEYYRETLANSAMSLDDGKQLRLTVSIGVSYFRQQNLQTMIHQADT
ALYEAKGRNRNTVCSF
>A0A173XGJ0|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKRDVIRKNSQEAELFPFAPIRRRFLIFCIVCVLAVMFSGACLTVRRMRQSAEAAYQSAS
AQISQKVGESIKLLTSLAALPEFYDPEVPWESKTAKLDEINQYFGYMFICYVDEDIEVYT
LGEEAASLASREYMQTLYSTREIQVTDGFVAGADGRTLNYTVAVPLIQDDVMTGSLFCSI
YFDDAVNLLKQSAAANGAEAVLIGSKGQIMSSTGDLAFGASYTEILHEYKLIGLTTDKLE
TLLLARDSGSFRSLKAGNSRYTVFGPIENTNWDILVTVDFLSLFAAELPSLLLATLFQIL
ITLILYLFVKKHIFGQMAIMENLLTSIHKMEKKLYSNAIAPESVDYEDILQMSSKGLRDE
LTGLATRTFFLNQLEKLLRDGNASGKLSLCFVDLDDLKLLNDTYGHQAGDSALKKIGFIL
RGYEKKYEGVVGRYGGDEFILILKDIDSVEELNDVLSELVERLHFTITVNGTEIPVHCSM
GACVWNRKDTLKTLISKADKALYDVKRHGKGTYSLFLNGE
>A0A202FEF3|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MLTKYVLQEMPLLTSLFFIFGVFIIYEILFDGVKSVLSLKEINIESGILKAQLGIMYLFI
LLFGLQALVVNHQATWIFINFQIVALIFCAVFLDAPVNYPIFIPIVLAFMIFNSAIFYWE
SWCFALTLFLFYYSLKYIKKKRTNPFPFIYYMLDGLFFGTILWSLARIKFSLNGTTIFQQ
VSYLIVFEIFVYSYIGFFIRDVRVKHTLYEFAHLDALTHVKNFAAFDNDIHALFNQHQSN
DINVAMIMFDIDHFKSINDHYGHLVGDKVLQQVADITQTVINANDGNIRFYRTGGEEFNV
ILPNYKLSEIDSITQEIFTAINNSQFKFNNQNVDVSVSVGSSEIRENDLNSDEFYSRVDD
ALYQSKRNGRMRITKS
>A0A1G0EB25|diguanylate cyclase|EC 2.7.7.65|Gallionellales bacterium RIFCSPLOWO2_12_FULL_59_22|TrEMBL
MIQLKQSIDFIADWHRLSAETPEPVRRLAGEIVRQHTVALADIFYQNMLSDEQAKSFLDH
ELVNQRLHVSLQRWLQELFSGEQHDPQTIYEQQCHIGEVHARIQLPIGLVMRGGRLLKHA
IHSYLVESSLERGDLVKAANFVAETIDLALDAMTDYFVIDMEKHARADEAYRMFALGQNM
LAERERQRAAILEWAQQILLKLLADGSAAQLPDIKHSEFGMWLQHKAAIIFESAPELEQI
RQRIDEVERSLFPKLIESRRNPGGAGALMKEVETGIAEIKFLLGGLFDRFIEVESGRDAL
TRLLNRRFLPAVLIREMALARRSAVPFSLLLLDLDRFKLINDTYGHGGGDMVLQQAADLV
TSSVRAGDFVFRYGGEEMLVVLVEVGSDQALRVAETIREKFAADAFRVGDRQTAGVTVSI
GIATYNGHPDYETMLKDADAALYEAKDAGRNRCVMSGR
>A0A161GKD6|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MVIDSRRRVLSSLLAVQLVLYSAAFIASWADTNGAGAVGEMWAAVVAAVGSVAILSRRPG
PVRQGIAIACAALAPALTMLTHQNLAAQVWALIPAMFLALYLRATYPVVVARVLCVALAL
LSATALLLAPARAPMLWGALYVVCILAAAEVFGALGAALIAGALRDPLTGVFNRAGAVDA
ATNLAARAARRSENIAAIVFDVDHFKAVNDRDGHAAGDRILIGLADALTEKVPAGSVIAR
LGGDEFIVLVAGLDTAQIDTLAQELVDGHVVSVTYGIAVGSPGPDVLEALTQVADADMYR
RKMLRRRR
>A0A2X2CUJ5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MDEQLLGPLSADETMLALLHSRAEAERLRERERLFSALLESVNSVLWALNWQTGEIIYVS
PAYEQVFGRPIALAMTSYDVWINNVYPDDVEYVQETLNQVLQQGAMESREYRIIRGDGEI
RWLSDKCFVSQRSEAGMPLLVVGIAEDITEKKRMEEELQRLATTDVLTRSSNRRHFFESA
QRAFELAKTTAEPLAFLLFDIDDFKKINDRFGHQMGDLVLQRVAECGAQMIRRGDLFGRI
GGEEFALLLPGCDRELAEQIGVRLQRAVRQLMVPTPQGSLRVTISQGLAVLKEDDKGLDA
LYARADEAMYKAKRQGKDQIVQG
>A0A5E4TIF6|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MVKTLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSSLQAQLDNQVKLVADQLDDKVR
AKYLALHRISRHLGNPYAMTAAELDAFANASVSMPETFNTLFVAAPDGRVIYDSTFPATP
INIADRDYFKALLGGAPQAISGLIAGKITRSPGVVLAVPVRDAEGRLTAVVGGAINLLRQ
NFIVDLASNAVGDTGRYCLITNETPARYVIQADVTKILSAVGPTQTLCGVRDAGANELVH
MHPLVARTAMATTGWSLVAVLPGAEAFDPLARVRRRVVMLAIAAIAIAALVMWWVARWML
RPVDTLRELVERSASDLRAIQSLPVQRADEIGALANAFREMMERLGDRTDALESSREAAR
ANVRRMQEIADRVPFLVAFLDGEERFAFVNRACEVRLRRSREHILGSTAQELLGALLYRE
FAPYLARAYAGEAATFVWDFGENSEYRCFEVSYQPEWTANDVLVGVHVFVRDITIERSNE
RRWRRESHTDHLTGLLNRKGFDQALAAAVRRAREGAGAQALLFVDLDRFKLVNDTWGHAL
GDELLKRLAKRLVACVRESDDIARFGGDEFAVIMRDIHDVQDVERAAKAVLEVASRPMAL
SVGDVGVGACIGVAMVACGEDKTPDMLFQEADRALYEAKHGGRGRFMFSDGASVRSL
>A0A381A3N2|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVTRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A649YXV1|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MISELDLAIQLTKIIILLYISYLLLRHQVSNKILYGCLLAMISMIIELFINYCQLSWPAI
SSDHKDEVLLISSTTLLIAHILMLSGVSSLYFKLKEESEKDHLTQLNNRKFMRKIPEKDY
DVIYLDIDNFKSINDTLGHDYGDALLVLFARYLSHCILKNEYLVRYGGDEFIAYVQPGRS
GDFIERLLGYVANSEIEFSYGISGSAKGELFSAITRADKNMYLMKRRRSTSRGRKPAQVN
ET
>N9NV99|diguanylate cyclase|EC 2.7.7.65|Acinetobacter variabilis|TrEMBL
MNNECMAMLAEQWKQICQNYSSDDLLHAFQFIQDHSSVLVEEFYKNMLLEEEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
MFELLSLNPQPNMLTTCSYIVQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDTLNQAVLKCTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDSDERRALNIAENIRKYVEHGLINTAQGQQFRLTVSIGCAL
FDGHPDYQRFLDAADAALYMAKNTGRNRVYLAQPSQIQGAQKASV
>I6CVE1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMR
ALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAAL
LPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDR
>A0A3R9PZY9|diguanylate cyclase|EC 2.7.7.65|Enterobacter huaxiensis|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWDSVSLTYPVVNIIEASIGAILLRKLLPWYNPLQN
LNDWVRLAIGSALIPPLIGGVLVHFLVPSAEPLRTFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLVTLAVTLVLSWAAISWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMMVSLMMARDPIVISPQTTVVMFNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLVNGEINTYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHEAMV
PEDREHAEQVLRDSLMARLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKALNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEEMSGWPQAEAIGQPI
LKVLHITFGENGPLMENIHSGDMSRSDIEQDVVLNCRTGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTLLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIHAINNYHFMWEGRLHRIGASAGIALIDDGNHQAAEVMSQADIACYASKNSGRGVV
TVYEPQQDRIHSPRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRAYAAPVAAKGMGVALPLSLAGLASVTLV
DELLELLEKSPLPGRLLHLTIAVEVLHSPDENVHQSLQKLRHAGCRVVLSQVGRDMDVFN
HLTPNMADYLMLDAEVVSNVHGNLMDEMMVTIIQGHAQRLGMKTLAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLELLLNTSYFAIN
>A0A221V2T1|diguanylate cyclase|EC 2.7.7.65|Arenibacter algicola|TrEMBL
MFENRIEFLPNYKILELPENDLEVVCDLARFIVDSDTAKVALLKLSNDHEELLQLESSGS
KIENLLGDFFCTEPAEYFLIDDFNNRKIFGSSVDHCHKHPKFVWIATLPESKDYGQEIIC
IYDEIPKKLVDKQIQALKSLVNQTGSLFAFHKKQTELDFEKTFVDNKNITIGNYLEANGT
GFWHWDLSSMNLTLGTMSLEILGYQREELNIRTLADWIELVYYFDQEKFMERFGNWSNNN
LLEEELECRMVHKSGEIVFLNIKISESRINDKAVLTELDGEIQDITTQKKVWEQIDLINP
GYTSVLQAGYNWLTIVDINGNYIYVNKALEKALGYSSEELIGQNIFSFVHESDNGKAANH
FSKFINNKPFVSKPFRFRCKNGSWKWIEILMVDLYDDPMIQGIVINARDITERVLINKEI
KASEEKHRLLFNTSPFPKYILEPNSFKIVDVNDAMLQFYGYTREELLTMSAKDLRPNEEI
DKLVQGVKDFQFQTGTMKSGIYTHKKKDGELVKMEIVGQHLVLDQIKCILVTCNDVTDRE
AYLNNLKQSELKLKSATTIAKLGYWSVDPIDLSFVCSDEFYKIWGRNPETFNFSFETFMD
TIYPEDKDVLTSENDKAILQKRKYEVVYRIILPDNSIKWIQHVGQPINGPDGNYTKLEGT
VQDITDLKSTQLQIEKTNEEKNNILESIGDAFISVDHNWTVTYWNSVAEKVLMVEKDDIM
GKNLWNVMENHIESKAFLKYYKSIHSGNTIYFQDYFSSFNKWLEVSAYPSENNLSLYIRD
ISDKQHNEFAIQKQNDKLREIAWTQSHVVRAPLARLMGVVDLFREGLLDENEKKPMLDHI
YTSAIELDDIIQEIVSKSQSVISNE
>A0A245ZS03|diguanylate cyclase|EC 2.7.7.65|Sphingomonas mucosissima|TrEMBL
MIDSLLSDEPARIAALQRLDVLDTAVEEPFEKIVTLVRTVLAVPIATVTLVDRDRQWFKA
KRGLEADQTPRSVSFCTHTIKQREPLIVEDAELDPRFAGSALVAGPPHIKSYAGIPLRTP
EGYNIGSLCAMDTRPRRFSPADIAIMSNFASIVCDELELRMIAQVDQLTGALTRRGFIEH
ADREIARTRRNGRPATLVMLDLDHFKSINDTHGHAVGDQVLQKVAAVVRATLRPSDVLGR
LGGEEFAVLLPETGAVEAATAVERLRGMIAAQPIALENAKTLHVTASFGAASLDSETTSF
VSWLKQADTMLYAAKAAGRNCARFAT
>A0A7U9R008|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MRTLGRIIRRYIQIVTLALVLGILVFIGCMEISKERERAYENAVSAFHQIGQTLERNQEE
LRDIGVEYSETCLYNAEAIAYMIQHNLPALESLEELKRMAEFMEVDEIHIFDREGCIYAG
THPEYYGYTFDSGEQMRFFKPMLEDQSLKLVQEVTPNTAEGKLMQYSALWSGDGQFIVQV
GKAPVRLMKATEKNELSYIFAMLKIDPAAIYYAVDMESGEIVGSTDLDNVGKDLTAVGLD
LRDVRSGGMGFHARVNGVHSYCVFEQIGANYVGRVMPDRILYQRLPANMVSLAVGLLLIT
FFLSSVVTWCMNRYVVGGIHNVNEKLRLIAGGDLEERVDIRTSVELSELSSYINEMIGSL
LANNKKMSYALGKTNMYIGVYEYARQGGVRFTEHIPRIFGLEESEAKRLSGSGGLFREFL
GQIFCRPLQGEEGVFQLDERYIKLEEIREGNETFGIAIDVTEEIVRRRKIEGERDMDALT
GLYNRRGLDARLERLFAEPEKLGHYAVVMIDADGLKGINDTYGHDKGDEYLRKIADTINA
FDPGNSLAARQGGDEFVLFLYRYEQKEELVEALRLLEFIQRHCKACLEPELRVRLEFSLG
YVMGRGQADYRELLRQADERMYENKRERKKSRE
>A0A484Z827|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MHIIAKLAAFIHFFVKIIMLAIGRYVKNRYIPFFLGSFFVIGILHFLFLQLVKHVPSFSP
LLFPTLTIFLLVFHSVIACFMVMKYWCDKRRLYLVAIALAFTGSALLMVGTLTSFPAWLN
LYQFSTINYNDAMIYYTFRHILMAVLFIVSALLYVLRNVLLSRMTQISLFFGMLLFTVVI
IALAWFYSSHSSLFSLDLIDNETRHFMAIWNRVINIILIVLWVATFVTLMIITRIRNMFW
VSGNFLSLCYIGTLLMMLIAGQAEDISWYRARLFETIATLLIIFVLLYDVFNLYRESHLK
YQQSYQNSIRDPLTRLYNRSYFYDALNHSLRSASRTQPVSVVVSDLDRFKRINDCYGHLQ
GDKVLKFVARLLMDSVRPDDIAARIGGEEFVLMLANTPPETARQVAERIREKLSSFDKNS
SEEQLPEPITISMGVFTATSAETTAETCVGCADKAMYEAKETGRNRVVVYS
>A0A7U9NGV4|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MGGVQLNKLGTLSEKQGERQPKEKDWDRLTGVMKKNIAEKKIAFKINERRGGTLFLCDVD
GLERINRQYGHQAGDECLKQVAQILSFMISPDDILGRSGGDEFVIFMPSCRDAQQAQEIC
ARIGNRFRANRGKGSIPLSVTVVHVLWQSGLTYEKLFECAAEKMKKQREDLEIQKEQKDK
EGEHYIKDVRQIRKELIEQIKKPGAYCRDYETFKSIYRFLERGIIRSGQKACVILITVVD
KQGRSLLPQEKDVLMEQLGKNIESALRIGDVYTRYSSSQYLALVIDTTEGQTDLIVSRIK
ERFLAGRQENNILIHHCYELQPAQIGERIEGYTT
>A0A411ZDE4|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MAFRFNGRTGRKRAAANTNEPVGSAPKPSEVLVQVEATGVGSFWATDAGGTLVYLSDKAL
KSLGVGANSLIGQQITSIFGEVDDDERDQVATRPLGFSMVSKSKIDNHVVEIHIPLDTGG
ERKATRWWRVSGRPFFGEEQEFLGYRGNCTDITGEFKQQLDVNRQSQYDELTGLANRRRI
NGRLKTTLSSFQSAGRSCALMMLDLDRFKQVNDTMGHPAGDELLKQVADRLRSLIQDRGE
VGRLGGDEFQIILPDMDDRGELGELAGRIIQMVSQPYSINGRRAIIGTSVGIAIAPYDAI
ETDDLNGAVDLALYAAKESGRGVFRFYSAELKEEASKGALLQEDLRDALEQGELVLNYQP
LVDPNTNKVKCFEALMRWNTPEGDSISPAVFIPIAEQSDLIIKLGTWALMQACNDAAGWP
DDIRIAVNVSAKQFMNADFRRTVAKVLKESGLPPERLELEITESVFVGEVGSVDETFAAL
KKMGVRLALDDFGTGYSSLGYLKRAPFDKIKIDQSFVRGCTMSGDTNPAIITAIVALAGA
LNMQTVAEGVEAMDELELVQQRGADLVQGYIYSRPMPNEQILSRFENGEYAFSPSGPARY
RSDRKTVYRKIGLIHEDHYYDVILRNISKSGARIDGLANVPKGSEVVLDLGGGQLAVSNV
ENSVDGSQGLSFEIPLVADGAEGLVTSRRVSPYALAEAGMPLEALGPGSYPMPKEPGKEP
SMPKFTQLALD
>A0A7U9X7Y7|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKSTKKLWGDSCFDRYCFWILIAIELLMSFTFLGYLHIPPISITIAYLPILVAGCLFGPV
PSSMLGLVFGIASMYKASGSYVMPADAVFSPFLSGFPVSSLLLSVGTRVLFGFLVGIVFQ
FVKSRKHYRIWSGVISLIAPKIHSLIVYTAMELLFPELGYHFYSAFHYDWDDAVFAAICV
SVVTLLLTVYQGHTVQNIKTCMDQSVNNPYDSGKANLFFVVFEFFIFCMAVSAAVYFSQR
ESYMLERHGIAVSAGIAGDLLHLQIQFLVASLSLNVISVILLISMYKYMSYREYKGEIDE
LTGAMGRRMFLYHCEKVQKGNRQGQKPLGWFLFVDVDYFKEINDTFGHSVGDKVLRDIAG
HLQSIFRCDGTVGRIGGDEFAVIIEHSMEQKELERRLKQFLQVIAAILPDKKVSCSIGAC
QFVLPRSVERILSETDAMLYQAKENGRACYVIKAWETDRPDDDSGA
>A0A5E0ZZ72|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MLAISRYVKKPYIPFCLGCIVVIGILQILFLKLVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDRRRLYLIAIAFAFAGSAMLMVGTLTSFPAWLDLYQLNVVDYNDTMIFFMY
RHLLMAVLMIASALLYIVRDNPLSRAAHIAIVAGTFLFMVGMVLLAWLSSSHSSLMSLDL
VDNETHQFMVLWSHAINIVLIILWVVTLATLMVITRVRNIFWVGGNFLCVCYIVTLAMLL
AGGHAEDISWYRARLFETVATLLIIFVLLYDVFRLYRDSHLKYQQSYQNSIRDPLTRLYN
RSYFYDSLNQALGACKASRPVSVIVSDLDRFKRINDCYGHLQGDKVLQFVAHLLMDSVRP
QDIAARIGGEEFVLMLTNTSSEAAYQVAERIRLKLSSFDKTSSGGQLPEPITISMGVFTA
TSVETTAEECVEKADKAMYEAKETGRNRVIVSRG
>A0A1J1LJV1|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MNQNGSNHSWQLKTHLQQSFFEKKKTDFEPFSRSMGLDLISLVLSVLLGLYLNSSVLNIV
LRDFFKIQVDMAFCLVLAGISLWLWYQNSSFVFQKFTLFWLKFQGVYQLACQILQQFLPR
IFLMGLFLRGLIFLGFHYPLYTREPEEMIQNLTNWVLFLIFIGWIIHHVNYMSYRHSQAE
DSNPLELKQNLPPGENDTSQPQEKLYQALLSAPHPMMLHTEDGEVIEINQSWAEITGYTV
AQLPTISAWSQRLTNPKPLPSTKNLVGGSRLPELRRNYLITNHQGYLRIWEWSTLTLGQL
TDGRALLLSTIVDVTEDQPTQTPIQQSQQSNEQLQLSLLQWTAELTQANDGLQEELQRRQ
QMTSELYQVSERLKQLLRSSPAVIFSCQPQPHYQITFISDNVYTLLGYEVTTFLKEENIW
HNYVPEEEKSQWQDAFIQVLTTGTYIHEARFLHAQGHWRWLRLEMRLIKDGRGNPLEIVG
YFVDITDRKEAEMQLLTTQNRLKTVIETVGNGIMLSDEQGNFYLFNPQMTEITGYTLEEA
QSHSDFLALLYPTPEGYQKAQERLKKVIATGSIFNLETTIQAKNGQLKTLLLSTVMMQDQ
QHRLFLSTFQDITPLKRAEKALCQLIVQEHLIWEITHQIRQSLNLDDILNATVKEVQQLL
ECDQVLIYRIFPDRRGKIIAETEPDESLKFLRNQQSKTPLIPLECYENFNQGRMRVINDI
NHDPIHSGMLKVLKYWGICSAIMVPLFEQNQLWGLLMICQNHGLRHWLQWEATLLRQISE
QVGIALQQSQLYQQTQYQARRAQTLNHVIQFIRQSLDLDTIFSTAVAEIVTLLRVDRACI
LQHLPQEEQWKEVASYSYDRNTTPAILSPIQQLHHSETEDLTVPNSQEIQHLTGISGTWL
PIPLRVGSQVWGCLGLLKHQHLRGWKESEIELTCAIADQLAIAIQQSELYQELQVANQQL
KRLATVDGLTQVANRRRFDEYLEQEWQRLQREQGSLALIMCDIDYFKQYNDYYGHPAGDS
CLKQVAQAIENTLRRPADLVARYGGEEFAIILPNTNQDGAIHVAQHIQGAVLQLEIPHDK
STVSQWLTLSLGVACTLPSPLTSLSVLIEAADQALYQAKQQGRARYCVQPV
>A0A128F0M1|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MSDYAFFEATRIFKRAVPMMVKYKVPTTPHYFSLWYTYCAGTNPQLNQAVDETVTRFGSC
SPLHCDNIIETYLLDDAKREVNNFRQKLQTLAADLGDSMGSTVSDTEEFRDILSTSVNRL
KNVKSHIAANGESKQVLQELLKGSQHLLSATSQYQIQVSSQKTEIDALKKQLQEYQKQAS
HDALTGCLNRREFEKQLEDNVHQKNVFSVMMVDIDHFKSFNDEFGHQMGDKVLQIVAAKL
QQVVDESGAVFRYGGEEFVAILPSLPLKSTFVVAEKMRSTLERLSVTDKRSGQKINSITA
SFGIAEREGDECGLALVARADEALYNAKHKGRNCVMPQVR
>A0A1J1LD87|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MKNETEAEVQQQKLDFQVVNRALAVLSACTQAVIRATDEITLLQTLCQLITQEAAYRMAW
VAYVCHDEAKSVKAMAWAGYEADYLENVNITWADTERGRGPTGRVIRSGHPVACQNMLND
PNFAPWREAAQQRGYQSSLVLPLFNNNGEVFGTLNIYSAEAYAFNPKEVELLTQLTDSLS
FGIVALRAEQALRESEQRYRLLAENINDLVCLHDQDRRYLYLSPSCESLLGYGYNELIGK
DPYILFHPDDRDRIVEEFRAVILGKNDISITYRIRQKSGNYIWLETLTKPILNEAGKVVQ
IQTTSRDVTERILVQERFKYEALHDALTGLPNRNLLMERLKLGINRIRNFEGYRFAVLFL
DLDRFKVINDSLGHLVGDQLLIATAHKLQSIVRSIDLVARIGGDEFVILLDEIKDIQEAI
RVTERIFKTLTSPLIIEEREIYVSTSIGIVLGTKDYIRDSDLLRDADIAMYRAKNQGKAR
YEIFDREMHAVAIKRLHLENDLRRAIEQQQFLVYYQPIINLSNHRLIGFEALVRWQHPTR
GFISPIEFIPLAEETGLIIMIDSWVLFTACQQLATWKIKFPHYLPLKMSINLSAQDFRKI
NLIEEIDHILMETGLEGQELTLEITESMLIENINKTIDLLTEIKLRNLEISIDDFGTGYS
SLNYLHRFPVDYLKIDSSFVSQMQEENRNYQVVSTIIDLGHHLGLAIVAEGIETGQQMRW
LRELGCKFGQGYLFAQPLSAQEIEIKFLHK
>U5MTU5|diguanylate cyclase|EC 2.7.7.65|Clostridium saccharobutylicum DSM 13864|TrEMBL
MNRDFKDIPTEYLAKIFDTVRIIDFKNNRVVIENVKNINSSVDKNCYSILCKDSICKNCI
ASRAYYENETVTKLENSNDKVFLVMATPITDGEEKYILETLKDISSSIIFDDQNLPQKEV
LVDHMKRIDELVVKDELTDVYNRRYLNERLDIDIKSSIMNNFELSLVMIDVDYFKKINDR
YHHIVGDYVLKEFVNVILNNIRSDYDWIARYGGEEFAIVFRNTDIKEATLYSERIRKAIE
NHNFKYDNINISVTASFGVSSISEEINNSGLLLQKADEQLYVAKRKGRNRVENA
>A0A6J4F3E7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MGAVSKVWAVSLGLPVSLGDKGVLCLRMNMTASSFNDVLGEQRLPEHWTGVLLAADGTTV
ARTRSPESAIGTKAPPSLVKAQAERRTGLFPTLTREGVPSSTALSKVPGWDLWVAIAVPE
ASIDAEADRFLIEVAVAGCAVLAASIVVALWLARHLAGQITRASAASAALADGHADSVPD
SDIVELGAMGAALGTVKAREIETQAALLEAVSVNEQTAAALSQAQCDQLTGLAGRGLFLD
QAQALKDNCPDGSGLAILFIDLDGFKAVNDTLGHEAGDRVLVRAADILRAAIGAGDVVGR
LGGDEFVIGVAGPIDAIGELAADIAGRLVASIATIGDGIGCSIGVATPHPGPERLGDIMK
RADQAMYAAKRHGKNCYVVAQR
>A0A174QES6|diguanylate cyclase|EC 2.7.7.65|Dorea longicatena|TrEMBL
MMWFLLLCRRKNRESLHEEDKLYDGMAIVNLAGALSETIAFLVDGNQFTGCRQINYISNS
ICFIGTVSIGLLWCLYVELRIYRNYKRIFKKVRVVMFPWIVEVIMVLCNLPGTGIMFKIS
KENVYQRTAGSLVGYISLILYFAYSIYLVYHSKKQGVNVNFFPVIYFVGPCFAGVLIQFL
FYGITSSWVLVAIALIFVQMQTYAENLYMDELSGLYNRRYLNAVLSERKFMKCKSLYGIM
MDVNAFKYINDNFGHSMGDKAICTLGNILFRSIPAAGMAIRYAGDEFIVLLSGVEEESVL
ATMKEIHNNLSRFNESGIEPFTLSVSMGYAEFGSEDDAEVFLMHMDEKMYEEKRKYHLLK
KSDN
>A0A376EZ89|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MSERDRDQLLSQATDQYWQHIIPIVWLALMIHVGLIFLFLSMSIPTLAIFNIFSVMVYIH
CLNEIEHYRYLYVGTLMSVEILAHAIVTTVLLGWESNFYLFVFSLIPIVSFSFQQVPVRR
ALFLAAIAVLGTAGYALRHHTGTASGLSPSVLNSIGIANAVMAISFLMYTTLRSVEFTHT
MKLDLFNTASRDSLTNLYTRRHFMHQVALLEKESGNPNVALLLLDIDHFKAINDSCGHSY
GDMILQRIARAITDNVRESDIVARWGGEEFLVLMPDTSLSDARRVAERLMGRIQEWVGQT
EKNPREVTATLALSALGKDEAFEKALNRADKMLYAGKQQGRNRLVMAD
>A0A375J8Y5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MLQRFSGQAWQLLASRPHRFVVASFSLSVMLLLLLLWRGLQLSQDREIETLRHMQAVRAQ
SMDALLQREAERLLSVRNFAQHLLQIQATAPGASDADLRATLAHRDQPAWPVPAHDAAAV
YGVSAAALRGVEGFARDEARLAADVIVARSLSHLLSAAPEGSGIRRRIAYVSRNGVLTAY
PSIPQQEVVSAVQRLAAAPYFRDSLPARNPGRHMQWRIAPATVARDQVSLFLSAPVYAEG
HFRGVAMLELPQRSLDDQLSSAPFHESSSYLVDREGRLIGASTRNVRAGETLQAALSGPW
PAATLEAVFHADSGLLDGVGGASGASGSDLMFRRLRQGGLALVDEIPVNQLWLASAARLS
GVIGAGAAALGILLCATLAVVHSLFRHYLARGEALRTLAETDALTGLANRRVFAARFAAE
QRPIAVVMLDIDHFKSINDRWGHASGDVVLRAVADALRGGVRKADLPARLGGEEFAVLLP
GTGVDDAAAVAEHLRQRLAALRCEPAPDAGSTEPIRFTASFGVAGLAPGDHGNLDALLMA
ADRRLYQAKANGRNQAVAR
>A0A399EIX4|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MLGLEGLLNSPQTVVWLDPQGRIGWHNWAAASALLRLGLEGQPILPLLEQGSRLRLVEAE
SPITLPYQGHCTLVIEGKPRHWYRFFCHPYQGGTLCFGVDVSDLYSKALAYQTTLEVLSN
LVTQEARFEDLLQHVLETAVAVVPGAQAGSIWYYSGEQFRLAAQVGFSQELMGIAISYQD
ELKWYGAGEEAWKQGQPRLLRGAQIIARSVQALREGPGYELGKISKIQANLCVPVVLGGE
VMAMLNLDNLEHPDAFPPEAVAIASHFGLQTAVLLYGVLNQRNLSELAYTDPLTGLGNRR
ALSEGFARLRTQAQRLGKPLTVIFWDLDGLKQINDQHGHIAGDRVLREVALALQTLLRHG
DRAYRIGGDEFVSLHLDLSEGEEGPLVERVRSALPLRVSAGAARASEAMSLEQVLELADA
QMYRDKPPR
>A0A399EUH9|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MNSLESPQQRACRAYWLIAALAIGPALLIHPFFGRWPEFLLDGVYVVATFAGWRLAPRFT
PKLVITLHLVLSFLLVVWYIAQPQSLPSRFSFQEEAYVALLAPTVMGLSTVWGTWGFAVA
VPLSLSRLQNPTLPEQLSAGYVLVFVALLGLVTHYGLRRLEEAHENLANAALQDPLTQLG
NRRVLEADFVRLQALAKRAGVPLLLTLWDLDDLKSVNDDQGHAAGDAYIRDFTQALRLNV
REGDGLYRLGGDEFCGLHLGLSEGSSVSLRVRAVFPNVSVGWSEALGTLDETLAQADRHL
YAEKASKRPIKLPKLPS
>A0A8K1ISH9|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MTLVPSNTSIWDLFEHLCKCVCRFDADGQIIIANGGFYEAFPLLNGGDEHSGEPDTLEMP
SDTWASQTIFARILEGDRQRFYQACRSLSPSQPEVSLTLSSSATQPEAWQWTVRARFRDS
GEVLEYQALAQPGGDRPLVTPSLCRREVPEVNIQEAHRYRLLTHHAPVGIFQFNPQGEVT
FVNPSWCKITGLSLDDALGQGWTQALHPEDYDRVVEVARHIREEITSCEFRFVTPQGQVV
WVLGNSVPLWDEFGNFQGSVGTILDITERKQAQNQEAQLKQLSRALEQCGDNVIITNREG
KIVYVNSGFERLTGYTEAEALGATPSILRSGFHKREFYRNLWNTIHQGQVFYGVFTNRKK
SGELFAEQKTITPLRDERGEITHYISTGKDVTERQRAEERLEQVNRCFLNFSSNPLENIG
RLTTLCGTLLAAKGAIYQRSLGEHLHSVCTWGDVSFEQQGNKQSLVEWLEDCGSSSACPR
LETPGDTWYEPISRVWRTLVRTGDRVVGLLSLGYAQSPQQSADDRRLFGIIATAIAIEEE
QHRVAEALRRQMERDRALSKLSHHIHRSLELSEILPATAKAVREFLGSDSVLICSLNEKA
SQATVVAKATILEDPPLEQVVLKAFSLKTNCLEEYRQTQHITRLPIKICHRYCELEGFKE
SKTHIIAPILQGTHLWGLIIAQNCRIYRQWTESEQEFLRQVATQLGIATQQSKLYEELKV
ANGSLQKLATIDGLTQVANRRQFDEFLAQSWQTSLEQQQPLGIILCDIDFFKPYNDTYGH
QAGDDCLKQVAGAISQTVTAEDSLVARYGGEEFVVVVNGAKYQRIITLVQEIRRAVESLQ
IPHRSSNAHPWVTLSVGAARLIPRREWTSEDLLRRADQALYKAKADGRNCGRVAKC
>A0A433DPZ2|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. NP10|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQSVVDGIVEGLGYELACVNLVRPEGD
LVIAAFAGNAAAEALITGRVGSRDSWNRRLSMGEAWGSLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASAGGGDLLGVISVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRSNMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQQGRLLR
TNDALCRLLGRPASVMRRYSFADLVHPEDIGTLLRTSAEGGRAELRLSRRDGTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRHELNLAHRASHDALTGLPNSAELKSRLSARICER
PHSSPAATAIEALDAAYGDVESSLTHGYRADGYEGEAIPGGGPFDHHVHTVAPDPEHDDG
TKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLSTCVRDGDTVARLGGDEFVVLAD
GLGAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVE
KRSRSKVHRRAG
>A0A679K554|diguanylate cyclase|EC 2.7.7.65|Hyphomicrobium sp. ghe19|TrEMBL
MCNMSQADVLFSEANSFATLELSKIMSASALKQLPSSAIIMLGSVAAICSTFLLWHLLMH
SQIEISAISSWSDVSWQIAEVDSRGRIVRLGSHPFALALLFGIVAAGCMSFAWGAVQFFR
GGFSADKEIDERLSERLEKVGQELDDEVFSVMRLLKEHLELSGTHSDSLTKVSNTLVAST
SPERVRSIIQMLISENKKVQNEVRELNTRLQHSQQQIEKLRVSLSDSHKLGMLDAVTSLK
NRHWLEIHLPKEVGTAVETKGSLSLIMADVDHFKRINDSFGHAVGDEILRRFAELLSKNI
KGRDTAARYGGEEFIILLPQTRLEGAKNLGEQIRGELESKKWMHHRTGQPIGKVTASFGV
AELRPGEDCYALLDRADSKLYEAKAAGRNRIAADE
>A0A399FB15|diguanylate cyclase|EC 2.7.7.65|Meiothermus granaticius NBRC 107808|TrEMBL
MVADTPASFLEPPPAPAEVAQVEAWVREAWENRLASRTYSQELSQKALDLARSTGYLQGE
GYALRNLGFCQYQASNFTEALPLLSEGLQIAQVLNDAGLERDCLNYIGAIYAGLGELERA
LEYVERTYRLNQRIGDQSGIAASLNNIGIVYKQMGREEDSVRAKLEGIELARALQDQPRE
AFILCNLASSYIPLGRLQEAVQVSYQALELCQALNLKDLEAKVRVNLAEALAQQGDHAKA
LTLLDWVLEHAQNTGLKEPLIHYWINVATLHASQGSHTQALPALQQALLETQALGAKDLE
LQVHQRLWETHKALGNFERALQHHEAYHQLETTVRAESVERRLKVFGITRDLEKARAEAE
IERLKNVELARALEALHQANLEKSALVQALEEQVIRDPLTRLYNRRHLEATLAREYAQAQ
HSQQPLAVAIVDVDNFKHVNDRFSHLIGDLVLQKVAEIMSQNARESDFLARYGGEEFVLV
LPQSNLETARPVCEQLRLAVAAYDWSTIHPELQVTISLGLAADPHLPNHEKLLDSADARL
YEAKHSGKNCLRY
>A0A1V6HPP2|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MRSRAARRLFPLVLLAAALAARTGAQVLPFEVLGLEEGLPQSQVADVAQDADGYLWVATW
GGLARYDGESFTPFFVGQGLPSNRVQELLLDRGGVLWIATGSGLSVWRDRRLAPVSDPDL
DGQRCRALAEDGEGRLWVGTDTGVLVREGEGFRPVGPAGGIVYDLFPDRGAMLAATAGGL
LRLAADGAVELLPTPPLPPDTLRAVARTADGLWLGTAAQGVFLEAAGGWRPVPPPEIAGR
NVYRFVVGASGTFYVATQDGGLSRKPPGGARFEHLSTANGMPTDVVSTAFEDAEGNLWIG
TDIGGLVRALGEGASHHGVRGEFPSPCVFGIAPGGSADSLWVATLRGAVHYQVRPHCRVL
ETVGAREGLRDQHVWKVVTTPEGELWVQTETIYQVRPPGADRFAELPPSVPAPQTTQDIA
VDAAGRLWLAGYDPAHGVAMRDRSGRWHAWSASDDGVDVRRCRVVAPRRSGEVLVATGRE
ILVSDGERLRRYCDPPPLAGTYVSALFEDSRGRLWAGNDAGLARRETDGRWRLLNDEPGL
ASHHVFFAGESRDGAVWIGTARGAYRFLPGGRVEPFTLDDGLAGLEANQFGFFADPAGEV
WIGTVAGLTRFDPTGRHGNAVPPRLVVESAGLPTRSIAYPAALDLGWRERTIDFRVAVLA
FRNHARAAFRARLDGLEETWLPLRRPGELRYTNLSPGSYRLLLQAANESGVWAEKVALPI
RVHPPWWQTVWFRVAAAAAALALAVGIHRARTLALRRRNEELARAVEARTAELRAANAEL
EHLATHEPLTGRWNRRAILEQLRAHLAPRGTACRRFGCLLVDLDGFKRVNDTRGHAAGDR
VLAAAAEQLARSTREHDLVGRYGGDEFLLLLPDADRDAVTAVAERVGRIQIHEGEGAGAL
TVTASCGGVAVAAGAGLDETAVLAAADALLYRVKQAGGRGALIETLAPAPGNPPAVPAAS
EPGP
>A0A1V6HU94|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MDFESLIEAFAAGIYVLLGFVHFDLWWRDRSDRGPLWIVVAAAGALIVNLTWMAHRTLAG
AHERELLVLNHGGVAITTVALYELAAGLARKPVGRLGRALQLAVFAAALLAAFGPSWAVL
TPVAAGLLLIGAGARALRSATTRAPGALTFMHCYMFLIASLALDAAREAGLEVIPPDLPV
IGFIVLFLGATTAIADRRQREYEELVRLRHDLEELVDERTAELSAANRQLEEMARSDWLT
GLPNRRGFLAAVEAEERRSRRSGRPFSVALGDLDHFKRVNDEHGHATGDAVLQAVATAVR
GALREQDLVARWGGEELIMLLPETGLAGAVAAAGAVREAVSAVQLAAADKRLAPLTISVG
VAEHRPDRSLEATIAAADRALYRAKAEGRDRVAAD
>A0A6N3F0G6|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKKIALIMDGWKRWFTFAWPAGILQRIRQTGEEVSLYIFNSSGGWSCDEEYNTGEYNIYR
LPDLREFDGIILDLNNIGYPEVWEDVIRRAKESGVPVISIANEIEDFYYVGINNEKAMRM
MIEHLYEKHGCKKYWFVMGPEDNYENVKRIAALRAYMDEKQLTYSESDFYCESFEYQCGV
NGFEKLLETHDKGRLPQAIICGNDNIAVGVCEAATAHGYQVPKDFCVTGFDNFDKAAYYE
PRISTISHIRENVGIACVDLFLHIWKGEKPDRFYYTDTEGIFWDSCGCMPGEVPDQAEYL
KGQVMYGIETARFEDEVFSLEYELLKCNTVREMMYCIPQCIPSLKCDAMYLILDSHMDTY
KEQVKTHRSLSFFEEEDFHVEGYPKCVQVKFAYKNGKMLDTDQMEIEGIFPFFEPQKGGT
DFLFLPMHFRNRTVGYFVIENAVYLMEKQYLFQVIKTLTNAMENLHKKEKLEHMNQILSD
LYVRDSVTGLYNRMGYQKLSISYFTIMREKKMPVLVMFIDLDRLKYINDTFGHEYGDFAI
VSIAKAMLKHCDADAIAARTGGDEFIVLEGAKDEESGRVLAQKIRTELSKTQRAMQLPFD
LGASIGAVVAHPGEENVLESYVKRAEMLMYEEKAEKKVSRDS
>A0A173UPC4|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MNKEIRSDKRIKNIIGIIQSCLILILIFLIVFMIIQINRLQGTARVINYAGLVRGATQRE
VKLEITGNQKDELIKYLDNILSGLRYQEGQYDLVKIHDKEYQDKLRIQSEYWEKLKTEIG
EVRSKGYQNTDIVNMSEIYFEMADETVFAAENYSEKIAIKIRTIEFLSALDMFCLVILII
MQTLTAMKMAMNNKLLEQKAYTDAHTGLPNKDACELLLNTPEKVKESTACMMFDLNNLKI
VNDTMGHSAGDRLIMDFAQLLRSVIPEKNFVGRYGGDEFMAVIYHTSKTEVEELLKSLYR
EKDRLNSNENQIQIDYACGWAFPDEDGAYTMQMLLDKADVYMYENKQLCKKRKI
>A0A6N2ZTG5|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MKVKTILGRIYYIIVAVCVFLHVVILSLSFFDNKHQEKYCRSIIPDREYQTDEDNRRFVF
SAQKIKDGGDCLRFYTAHMEVSVYADDTLIYHVGQQQAMPKVSPGVMWNYVGIPSGAEQI
QVMIRAVYPEVRQKQIDFSIGGYTQMYSGMLYRSMPVTFICLLEILLGFFMVLWWLIART
RMKMKQTLLHFGTFSFLTGTWALNETDAALLILFPVRVEIVFVSAVALILMVPSFVWFTK
GFFDVEDKWGSDIICALAYLNLAVQLILQLAGIRGFRQMYTVTHVLLGVALLYTIVMLIS
EYRKTKVHRHLRFVVVGGFILLGTLAADLLHFYYGSFQTSIYGMYGVFIYIIIFAIEVCR
QVAEQVDAGRKLQIYEELATKDMLTKLYNRNAYDEWIKVNRRPKKAKIVVFDLNNLKQCN
ETMGHAAGDAYIQNAAGIILHVFGNCGNCYRIGGDEFCVVIYGNDPSDMEELFRQMKQEQ
DEFNSKNAIPQIQIAYGYAEFDPETDRDIEDTRSRADDKMYQKKREIKAGYQ
>A0A6C0XLF9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri|TrEMBL
MDNECMDMLAGQWQHICQNYSSDDLVHAFQFIKDNALILVEEFYKNMLVEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDEQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDKTKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGMQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSMT
>A0A0P0F5T9|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTNSSDTRSPSDSLGLVLDEHLRWIGQWHRAVFFRSGQGGERVSAPASFAAWCVAVNADD
LAHQPAVEKLVTLHEQMHRKAKLLLLKAAGGESPSEADYEGVIARFEEFVLHLRRVERAF
GAAASGLDPLTGLRTRRGMQEALEREHNRFRRNGPAFCVAICDIDRFKGINDTYGHDIGD
RVLAATAAAISRGIRSFDEAFRMGGEEFLICLKETGLAEGFRVIERLRGELARTPVTLPD
GRRIAVTASFGLVEAGEDLPVEEMVVCADRALYQAKNSGRNRVVRYGVDQPEVAAGRSAL
PNRR
>A0A2X3IWC4|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MRLIGTDATVTLFVWLSLGVLTACILLASVIALGISRHLHRDIDAALQNITDVVHDVRSN
RNFSRRVSPEKIEEFPPLCPGLQQPAG
>A0A8J7R108|diguanylate cyclase|EC 2.7.7.65|Tianweitania sediminis|TrEMBL
MWRFVDAQIGRKPQSSPSHDGQKTSVTSSSQQLLERFLSNPVVMAQVEQLLSGRTRDIHL
KGEIRRAFEQRSWRSAASIIRSWMVFVILLDLLLLALSFFLLSRDTALAITAPSLVIIPA
ALGVRQIWKKRRPDRALGSALLGGMAVILLCVCWMGVAAGGPLLNRYLHVMLSVAITGVV
IFSIPFRQTVAIAAFAVSLFFATQIAFSTESVGMILFGVLFFGSGMAATVLGRRTMNKLA
YKAFLLELRDRQRLSDLARSNRRLEQLSKIDGLTGVANRHLLRERLEDLRQAGGTVAILM
CDIDDFKALNDHLGHLDGDRCLVDVARILTNFTRSELDCVARFGGEEFLVLLPGVTEADA
MAVAERIRAAVAAAAHPNPLSRVTPVVTISIGVAVGSTTLPDNVLQKRADVALYDAKRTG
RNQVRLWIPALDSRNALYNVA
>A0A8E9YR55|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Inverness|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>D0SBS2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii SH046|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIEIK
ILQLLAEFPLENNHHMLSYMLQIMGFATEIMCRSYEANTEQSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSKHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDRTRALQVAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A2U3N2B5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter stercoris|TrEMBL
MVGDEVLKEMANRLNSRTRKDDFVARLGGDEFAIILNSITKVDQLIVFAENLIKCCETPL
YYQDLSIQFSFSLGIALSDNASSPEDLISQANQAMYKAKTLQHHWYIYHS
>A0A1A8T3D1|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MLTNTAAEKPWVLIKVARSIVPPLGIAGILFSLVALFGYLTSYEVLYRPFTNGPATNPLT
AICILLLGMSLCLKKRYAKPLQLSFAGLVILITLLRIADIVTHSGLTAYISPFYDRVLMD
IEQGQSNSMGLNTAVMFFFIALSQLLFSTRQLALSQFVASISVVIPTISLTGYAYNLTGF
YGQMSMLTTVAGGALALAMLCLTAHYGGLRAILSPYLGGKIARKQTIAGYLVPTVLGFMV
AQSLSANEADEFGIFVVVMCWFIIIMVSVSAIYQERIDSKRRAGERLLAQAALNDPLTNL
PNRRMFNDFAQAELARAKGRAGTFWLLILDIDHFKNINDTAGHDMGDEVLIALGQRLKES
VRDLDLVCRMGGEEFSIILSGNSRQEAQQVAERIRHSIEQLEVKGWTDLHGPITTSIGGA
TNTPQNTIEDMVKVADSALYQAKQQGRNRVIFA
>A0A8F7QK82|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MSHEYGHCCRDQALKHQAGRLKEKLRAEDLTIRCSVEDFMLPLAIPLKMNAV
>A0A1A8T7M4|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MHNLKDHRVKAFLLFALLYWGAALFVIEYLGNIAAREAIKDHRNALQSDIAISRSKIEAT
IYEDIYIADALSLILEYDPTIVEREWETLARQFIQKSTHTRNIGVAPEDVIRYIYPLEGN
EAAIGLNFRKVPHQYAAVAKAQELQSVYLDGPLELVQGGQAIIARYPIFLDRPINQRYWG
TVSVVLNFDQIIFSSNLNEIQYADIALTRTNLDGEQQLIYGDLKAFEEADVLLPIHLPNT
QWQLASKLHYWDLPEVRQAENITKLFALIGAIVLFLSIYILFRAYRVAHKISLLDDLTHL
PNRRFFFNKLAKRIKKSKSDGPFVILNIDVNGFKTINDQLGHDTGDDLLRYLAKHLKLSL
DSCDTVARIGGDEFVIILDKADNQQASKKAIQRIHHAIDENIFHWKKESLYISLSIGSAL
YRGQSEDELLAEADMDMYQQKQEHKTRSAKSDSDFVI
>A0A5V7QWV5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kottbus|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWVTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1R7QBD9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MREIRSEYLSQKLYIAMSIIILSLCSLSIPLMVKSYRDYIKTNQALTEIQALQAVADLAN
KISRERAPANKLMSSNQQDFAQHVLELKLYRLTVDEQMQKTLEVLKHSNLPNLDLSLFDR
LDEALTQGRQQVDAYAALPREQRNAETMDQAILKMFNAWDRSHDVLKDVIAVSEGKDTAV
SNFYVQILLLADLRDQAGRAASNVMAHVAFKQPIPETNLARSLQTRKQVMYLWELIDTLQ
PERDKTEEFKVLHQAVYNEFLAKGLLIVERLMNESIYHRPYYLTGTQLTEAIVDKFSTVV
ELQNYLLKYSVEKAIIEKHKAQNILLTTVGISLISIFAALFTMIYARKRVFSPLIQAREI
LFDLSHSSIRPNPMDTKDQPANMYSLFTAIQQLKQTLQQRDALEFRLKNIAHLDSLTGVA
NRYALNEYIKLLENQPTQFSETCLMVIDIDHFKQVNDVYGHLMGDQVIQFVAEKLKENIR
TSDLLVRYGGDEFIVLIENVGMERALKIAEKIRSEIYEAKSVDNVRCPDLKVSISIGVAI
GATSWMALLEKADRALFQAKEQGKNKVVAYSVDEVNESYYI
>A0A839ESA5|diguanylate cyclase|EC 2.7.7.65|Dokdonella fugitiva|TrEMBL
MTTVLSPSADFVGRLSDSIVAARSLEELVRPLLEMLQAVTGLESAYVTAIDEPAGLQHVL
FARNSRRLQIPEGLSVPWEDTLCKRALEEGRTYTDDVAACWGDSDAARALGIATYTSTPI
RTDDGALYGTLCAASDERKPLAGGAERVLQMFSRLIGQQVERERLVQSLRVANDALATSA
LLDPLTGLPNRRALMADLRRRVAQADREHHSLLIAFVDLDGFKAINDRYGHDAGDRFLHD
IGNALVATLRAGDLCARLGGDEFVVLAGGPHESDPPQAAVDALHHRLQAATTRRFDLGDA
GAIDYSGPSIGVIAADPAVTDPDVLLMTADAAMYRVKRARREGRVS
>A0A3Q8XGE1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSILVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAKLPLENNHYMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTRKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A1R7QBJ0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNSLASSSKKLNKNKLSHYLLEEEVIMNWSTLKKCILMLVLACIIHVAWLGWDSFILLNP
QYWQVVNLDIVRIQFVLNSIFLLTLSGLIYPCYVLHDRVWVQRFLPYVAIGIFVISLCQD
SYFVGVLSPMTMIAYICLLTVGLVLFKRKIIYIMLIPATSFLVFSGYLSFIDVMPYSPLF
TINGKLLYNGFWLFSMLYFIAPILVTCLILFEILLSQWRHRERLIQHLSQTDPLTNALNR
RSINQSLDELHHDKNCPYAIVLLDLDHFKNINDQFGHHMGDTVLIAVSQKLGLHLRESDV
VGRFGGEEFILILKQSSALKARQIAERCRAAIEDLVIQNEDGRAIRITASFGIALAMDKL
KPQQLLDQADKALYAAKASGRNQIKSYLEINPCEIKYSAACGDTQHISPN
>A0A3S5D3L1|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MVQQFFAVMNPLLSLLLAGAFATLALRWTSQRHLGLISVAFALTSIAFWATAYGIGPNAD
FSRYVANVGFFSAVTLACVCTIMRAGLRVPVPMYIVLVALTVAGFAWFEVVMPSTLGRIY
VMAIGFNAISLVTLVHLRRKPNWALADYMIAAAVCFGMLLSIVRPILAHLHVLDIGAEGT
FLQSTYWATVVAFTPILSVGVGFVFLAAIALDIYEQVKTEANHDYLTGLLNRRGFETLVE
SDLTTAKKPALLIADIDDFKKVNDTYGHQTGDAVIRHVAEILAHHGQALYAARIGGEEFA
LYYSDMERPPLRAIADDIRLALAQSDGSGPPVEKMVTLSIGLHWRDTGEGLAQMLHRADQ
ALYRAKRAGKDRVENSAIQLHSIRPQARA
>A0A0Q0NNL2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MLDAVGLTLSILLYVWFIKSSKIKAVSWAVVLLINSLILTFIISINGAAYSLFWATLIPP
FSFYLVGRNWGSLLSAFAFAVCAFIVYEHSQNPEPLKIGLGSVFNIIEVAIAHIVLFRFY
EKTRFAAYDTLAEKNQLIKKLAETDKLTGLFNREKLDRTLSSLLKSSNFGFILLDIDYFK
EINDTYGHLEGDKALVIVSNKLKSVSPSKALCARWGGEEFVIIIEGATLDETKEIATTII
TDINGIYFHEKRLSVSCGVTVSRIDDNTLTVIERADSALYRAKENGRNRIECIL
>A0A0Q0HG52|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MVIGARLKKRLLLAFTAACFAILLAQTIIRHFWILPTFEAMTKQNDRIDIQRVESQLQQE
VDALSKMVFDSAAWDTMYEAAQQRDTQWFNSDYVIADALQRLDVNGWYLYDTQANIIGGG
SFNSDYQPYSPTVLESPNLLIKNDLIILSGDIDNSQSELTHKVRFITIDKTPAVTVAYNV
TKSDGTGEFVATLLLWSFIDEDFVENLTPGLANDISFYGIDEAPKYRDHLIRVFGEKRRA
VETTQHNRRLYLGVNDQAGDLLFVLSIASRERTYDRSLFDSSLITGLLISGSVFILFYLY
INQQVLRPLRKLYTLVNSAISNNDFSAREEYFGNNELHQLGRGMNELFTLIENQRDEILE
RHQKLKHISNTDSMTTLANRRALDKHFAKLASDADLASQPISMIVADIDHFKLYNDFYGH
DQGDKALCEVANLLKENTQPSNHFVARYGGEEFVIVLSNTDKHQALKVAETLRNAVASAH
ITHQGRADLSYVTLSIGVASKAANEAFDSDSLFKIADDALYKAKKQGRNCCVVG
>A0A0U1KGG6|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYGAEEIIGQSFELF
YTPEDLAGQLPTKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDADNNLQGFVHV
TRDLTDKWQRENALRKSEELFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKATAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIAQHFGCFFLPEDIASGLPEKLLKTAASAGRIEREGWLVRKDMTRFWAVTVI
TVVHDHNGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDC
EGRVVLMNPKAEEMTGRSQNESCGLPIEEVFVLWSPLQDKNQLVAFNQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLTHAIGQLGENEQHILCYVDLDYFKEVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCKNAPATEILEQVVADIAAIQFHWHGQSYTFTASLGAVPV
IRQIETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A379Z4K4|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MNARSYQELLNSKHRLSLFLFLLMNAASSVFTLLVPFQNKPAFTLPLLGIPLFCLAAFLF
TLQSPRLYVKKLNLFSCVLGLLWAAHIYLKSQHCAPNNQSFLLISLFSMFFISAIALTDN
FIAFCLHAVPSALVILLLDGMHNTMRIVFTTVLPIIAFSIHHLMLKRSEHFTQTLVANLY
NERDRFSNLSMIDPLTGLYNRRGLENKINMLPAAASDCHFVLLLDIDHFKAYNDNYGHTM
GDQALVQVAIAIRDSVRSRDIVVRYGGEEFLVLLTNVNEDYATQVAERVRQRVQELKIPH
RFNQFETTTVTLSAGISALDKLDVASAIRAADAALYQAKNNGRNNIQLAQNVQPAAV
>A0A1C3IHX6|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MPSGSSKQWPAKLLSLLFFLVVMSAIEFFHSKELSYLKDESYSEAKKQLSIIRSRIEAAI
VSDMYILNNLSTLVTINPDGDMKSWNKIAENIIRDGFHIRLIGLAEDDILNFVYPMEGNE
QILGIDYRDHPTQWESVEIARNIGNTVIAGPFELFQGGQAIITRTPIFRDPPFNQDYWGV
SSAVISLDELFEDVGIGILENKYKLAIRGANSSGKDGAVFYGSQDVFDNAFVTEQVSFPY
GGWYLALSGNEHVLMDVQWYRIQAVRLVGYTIMLMLAFAFFTIYRLYRIADSRSMHDELT
MLPNRRYFMYSLKQAFKVTQKQRARTFAVVNIDLDGFKAINDTFGHAAGDQVLIECANRI
KSELRGSGIVARIGGDEFLVLLPRIIDDQHVSSIVAKLRRAICSTPVVYDTHSIYLRISV
GWVIHNNNYSDVDALLKAADEKMYEQKRQIL
>A0A2H5Z2P1|diguanylate cyclase|EC 2.7.7.65|bacterium HR28|TrEMBL
MQKTTLTTMTILLRLDARGLITEAVPPGAAPLGQPIVELVLPQERERAEALLVAARDGEP
GWAELTLLLSEGMQRYQVASVPGEFATASWLLRPLPDSLRPPLDDPTALERWLGPFLVEQ
VEIGVLVFDPELVLRYGNKVAARLLTGAETLFPLGVSFDVVERLLGQEFFGPELGERLRQ
AFANGETLRQVELERRDGAVIELDYLPVWEDGCTVAHVLRLRDISARRASERRAVAAERR
YRELVELLSVVVYRAPADAIAETSYVSPQIQRLLGYSPEEWLRERGMWARHLHPDDREAV
IAAIEQAVAEGREFSLEYRMVHRDGRIVWVQDWGRVQRDEQGERFIHGVMLDITERKALE
RAHDEARARLQALLHTMPAVIFATDPEPVVNPSGVPCYRLQYVNEQIEQLTGYSREEFYA
QPELFASLVHPEDVTRYTSGCLQTDATGEPFALDYRLIRRDGSVVWVREYALLLRDSAGH
PVAWQGVIVDVTEQKRAEEALREAEERYRTLVEQLPGALLVVSAQPTWQADSTPAFELVY
VSPQIERLTGYPPEAWTEGGFWFHLVHPDDRQQVLACLERCLRERGSQAVEYRLVRADGQ
IIWIRHEATLVLDDDGTPRYWHSLLLDVTAEKLAEEARQEAEERFRLLAEHHPAAVTIVE
PEPVSLPDGTLGWRTLYASPRITELTGYTPEEWSALGVWMRSIHPDDREQVLAEIQEWYT
QGPRRPLEYRFLRKDGRVVWIHQEGALVRDLAGRPRYLYLITQDVTEQRTLLEQLRLAEE
RYRTLVEQLPGAVLVRPILPDEAAWMRNLPNFYVGPGIERLTGFAPIEWTTERFLTQLHP
EDRQRVIRTLIEADRTGASLSIEYRLYRKDGSVIWVWSISQIIRDSNGKPLYRQVLLTDV
TERKQAEEALRAAEERYRSLVEQLPGAVILRALSSRPLPDGSIAYEIQYVSPGIERLTGF
TVEEWYEPGRWSRQLHPEDRDRVLAAFRESERTGGPLDLEYRYIRKDGQVIWLWHVSRVI
CGADGTPLQRQVLLLDITERKASELALRDAEARYRALVEQLPGAVLVRSAFSEPGEDGTR
HYTFHYISPGIERLTGFTPEEWLVPGTWTRQLHPEDRERVFAAMHASEEAAEPLDIEYRL
YRKDGSLIWIWHRTQVICDAEGRPLYRQVLLTDITARKQMELALRTAEAQYRTLVEQLPA
AVVRVAPYAECQPDGVPGYETHYVSPQIEAITGYTPEEWKQPGIWARRVHPEDREWVLKL
FWQHEETGEPLRLEYRFLRKDGQPIWLWHEARVIRGPDGAIEARQAVLIDITERKLAEQA
LREAEERFRSLVEQLSAALVILEPSAELSTDGLPRYRARYVSPRIEDLTGYTPDEWAQQG
VLARSIHPDDRTRVLEAFEWLERTGEPVRVEYRFIRKDGVVVWHRNEIWPIRDASGTVHA
WHALIIDVTPEKQTEQALREAEERYRTLVEQLPAVVYVEGATPVRRPDGRMERPLLYVSP
QVEQLTGYSPEEHRRDRSLWTQAIHPDDYPRVRQETRKAWVTGRFHSEFRIVRRDGAVRW
LESTARLIRDADGKPLYWQGVMLDVTERKRIEEELRAAEERYRTLVEQIPAAVLVTSAIP
VLLPDGSLHYPITFLSQRIEEVTGFSREEFAATPGLWFSRMHPDDQPRVFAEAVRTDETG
EPFQVTYRFQRKDGRWVWLENRAVILRDRHGNPLFWHGLLIDVTERKRAEELLVAQTALL
RLIAEAAPLSEVLELLCRLVEQQAPDLRCSVLLLGSDGRLHHGAEPNLPREYVAAIEGLA
IGPSVGSCGTAAFLNQPVYVSDIDTDPRWAEYRGIATRFGLRACWSTPIRDAAGEVLGTV
ALYAFEPREPRPEEEQLLELATQLAALALERWRESEDLRHRAFHDSLTGLANRLLFLDRV
EHALARAERDGGGLAVLFIDLDDFKRVNDTWGHAAGDLVLQEVAQRLSSHVRAGDTVARF
AGDEFTVLLEGVTSPEEVRGIAERLLRALDRPFDLQDTFVRLSLSIGAALAPAAPYPDSG
TLLLAADQALYAAKRRGKNTFDITVFSRGFEPPQSGNEEQ
>A0A1C3INP4|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MPDTTDPLIGMKRKILPLVVFSVGFLITVLCFVFVALNQQRALITNLNSFATHQTLSLEA
FINNDVAYIGSGANFFYSNDQDNWGNFDRFAKQTIAHSKSLIALQWMQKVSVDEITAYTK
EMEEEYPFFKLFTIPKHQEKTYGYVLDGESAFIATDVYPNTEANNKVLGFYSSRERFKLV
IDNIKQTREANVSDKVRLIQDGLDKEIPKSGMLVYHPVFDGESDNLLGVVIGVVRTTYYF
ENLLASAVGDMNVYIRVTDTGFEAEDSPILFETKGYDSVFGHEITKTLALTNRDWKIDYK
IDSCISFYGYMVLAGIALVGTTISLLLAYIVNMQIREKDRLSRMLDKRTKELRFLANHDS
LTEIYNRRAFNKILDKTIQRSESFTLIGFDIDKFKGINDKFGHPAGDALLVHVIKQISLN
LKEGDNLFRVGGDEFCIISSISDREALKFYLECILHSVSDSCCEHKGQLLSCTLSIGATI
RSKEDIEELLQKTDSMLYQSKSDGRNRVTIAG
>A0A1H9AN85|diguanylate cyclase|EC 2.7.7.65|Azotobacter beijerinckii|TrEMBL
MPSISPEHQAAEWKRLLEQFPVAVATRVRELATAHQAVLAGYFYAQMLQDEEAMLFLTHE
QVKSRLQGTLQQWIAMLFAARPDEAELLPLIAQQQRIGEIHARINIPIHLVLRGARHLRE
RLFALLCQQPVDAEHKLLGQRLIGETIDLAMEIMSRAFSDAHDRNSRSEEGYRLFSVAQN
IGVEQERQRGALLDWENQLMFDLAVGHSLAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQGMQHIDGVLLPLFEQAAAQMDADRRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQNERTFAVLAIDIDHFKQINDAFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDINANSALGVAEKLRRQAEQERFRLPGEHDLQLT
VSVGVALHDGHPDYQRLLRCADRALYEAKHGGRNRVVLSGGA
>A0A1K0IT84|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator|TrEMBL
MPATRPCGLMPAARYDGAADGILEEIPVHLDQQTIAVVMMVFFCSTLIIAAGLVFALRAS
EAGRLWAFGHVLVSAAGLALAISAASGTGQLGTLGALAFVAGWLLIYRGVRVYYGVPAHP
AALAAAGVIVLGLIAATSGMPDGQQVVLCIVYGLLALVSLATFATLARAGRGRRGIGAPL
VLVASLVHLATQLAGFSHAMNLPVAGAAGAAPLTLFFAGPAGSGWVLAPLIATLLGLFGF
TVMAMEQIVAHNESGARVDALTGLLNRGALEMSALSLVARWQRDGQALSCLVIDIDYFKQ
VNDTFGHHAGDAVLREVAHALDNSRRASDVAGRYGGEEFCILCPHTDEQQASALANRILR
KVRAIELPAGHGHASVSIGVAQLRGGPGSKEALWRLLFADADRALYHAKEHGRDRYVLAS
SMAAPAAASASPASLLAPEPDLAG
>A0A381GM74|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSTTELHSLDLLTFPVWIVSPQTEELVFANIVARELMQDLCFTPLRKGIFSTHYQNDLTM
YLSDLRNHHHIVEILTVYRDGEEIALASRLSIQSLPDVGDVILFEGIETPTAQGLKASRS
ATYQRKKQGFYARFFQTNSAPMLLIDPSRDGLIVDANLSALNFYGYSHDVMCQKHTWEIN
MLGRHILPVMHEIAHLPGGHKPLHFVHKLADGTSRHVQIYAGPIEIYGNKLLLCIIHDIT
EQKRLEQELERAALCDPLTGLLNRRHFYQVTGPEQTYAISLTQDYSLLLIDIDRFKSIND
LFGHLKGDEVICALARTLESCARKDDLIFRWGGEEFVLLLPRTSLDIALNLAEVIRATVA
KVTLPGLPRFTVSIGVARHETNESIDELFKRVDDALYKAKHEGRNKVLAA
>A0A7D6Z3W4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIVGENSHCICRFGQWLNN
QSRYNEDDCSYVSKINATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFERQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEVAYRYGGEEFIIIIRTKTNEQACQAGLRLCRLIGQKNIPY
SDGEIAITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A7H9FWZ1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESTLGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVDVMKTHPAQAIPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A381GRP0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MTLKNVAAIIYDHIRSSDYVFRYGGEEFMILLVESDQSQASIILETLRMKIAEMRMAASA
TETFSITVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A5I9EVH4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Glostrup|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A378ZU93|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MNGAAFFLMVNFAVALSFSAVFFVAARRSQFPLAARWIGAGFCVASLSALCELLVAYAGP
PRLWALGAFATVLFGLTMMTAGIGEMYRRRIDVRGIAVFLSASLFLGYIIYDLPRGTPLH
AFLYQAPFATTVLVGALVVLSAPHRTGLDRFLGILLLATGLHFLAKAGFAVVFGAGSTAK
DYVHTNYALISQSLTAVLMVATGLTLLAKLVLEIMALQQTQSELDSLSGLANRRGFDRRA
DVLLREDPHGPHAIILCDLDHFKQINDTFGHHAGDAVIRGFGERLRACAGIKAVASRMGG
EEFALFLPGMDVEAAVQIAQRLRLEVMSLPDLPHDLKVTASFGVAPVPFQTSLAEACRLA
DQALYRAKNTGRNRVKLAAAS
>A0A8F9HTG6|diguanylate cyclase|EC 2.7.7.65|Polymorphobacter sp. PAMC 29334|TrEMBL
MENGSSATLVALSISVAVFGSFTALNLAGRIATAEASARRWWIFAAATALGGGTWAMHFV
GMLAMDLPAVYGVNLTLVSFLLPIVVSGIGLHVVARFPGNRVALACSGLFVGCGVATMHY
TGMAAMKIPGVLVRYDERLVAASIGIAIAAATLALWLAFRARGSFQRLVAAVVMGAAISG
MHYTGMAAAEFVVTHQPAAVAGPVIPRAVVAFIVSGAATFLLLLALVTAFFDRKLAALTI
HEVEALKESETRYRLLIENASDVIGVLDSNGRFVYESSSALSVLGYATDEIIGRHLTDFV
PVDSRDAAQRFLGRVFERRDGPATSELLLFQKSGDRRVFEVVATNLLDTPPISGIVVNLR
DITERTQLVAQLEALSETDLLTETLNRRGFGRCAERDFERARRDGEMLTIVMMDLDHFKR
VNDLYGHAAGDLVLAKVASACAAEIRGGDLLGRMGGEEFALLLAGGDMAAAIQIVDRLRT
LVSACTVSTIRGYVSVTASFGIAHVSPPISELSDALSLADEALYEAKNAGRDCIRIRA
>A0A8G0WJW9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MIGFGWGRERPTLRAVLGRRHLSVALLAVGLAGVAITVLGVLALRVYANHNLHLIARSIN
YTVEAAVVFNDSSAANEALALIASTEEVADVKVFDDGDQLLARWQRSDDSLLARMEQQVA
RSLLEEPIVLPVLHQGQQVGRIELVGQGGSLVRFLLSGLAGIMLCTVLSAVGALYLSRRM
FGDIVGPLRSLATVAHAARRERSFDRRVPPAQIAELNELGNDFNALLDELESWRNHLQSE
NESLAHQASHDSLTGLPNRAFFEGRLSRTLRNANKYQEHMALLFLDSDNFKEINDSHGHA
AGDEVLVSVATRVRAQLRENDLVARLGGDEFAVLLAPLHSLEDAQRIAEKIIASMRLPIR
LAEGQSIVTSLSVGIAYFPDDGRTPSELLNAADAAMYQAKRNTRGQWQMAETERSANQVK
NRS
>A0A011NKM5|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MAKLSNPSEIAREALRLLAVRRLSPSPDNYRALYNEIAGTDPGEALPHREFRALLASLPQ
ETLAQQRMARRLEQAFAASNWQQLGAGLSDLVRQVGKEQELPWNELLGDFLREWENKQAG
LTVARKREALERVLASGSSGAEVLFARLQGLVKSWSAGSPAGEDMPLLTAEPVETATSQP
QRTAEGAAETADGEGDSPAQLRNLFAYLLEALTGSQLANEPELAADARALVHKVRTASSR
GGLEDLLAGIKRFAFRLELLAEDRAELRAGLLKLLQLLLENVGELVVEDRWLRGQIDIVR
DIVAEPLNVRSIEDAESRLKEVIFKQSQLKHSLNEARESLKQMLAGFVDHLAEFADSTSD
YHDKIEVCAAKISQAEDITQLEQVLAEVIRETTIIQLNAQRSRDELRAARQRVGETERRI
AELQQDLERASTLVRHDQLTGALNRRGLEEAFEKELGRAQRRQSTLCVALLDIDNFKKLN
DSLGHDAGDAALIHLATVIRETMRPQDTVARFGGEEFIIVLPETPVEDAQTAIVRLQREL
TRRIFLHNNNRQLITFSAGVTDFRPGDTQASVTKRADEAMYAAKQAGKNRVLIG
>A0A173R8I2|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKKNQTQIKKYAAVISIFLAAVIVGLFVFFFCIKRSVEQRSKNTMRNNVVRQSEHLRTIL
DIQYDYLNGLTEEIGKTDHLLAKKNMDLIKSITKHTDFCGTALIEPNGDAHYDNGLIKNL
SHRRYFKEVISGKRTLSDPLDSSISGSTRVVLGVPIYNSKHKVIGALGGSYDVTALSRML
FEDLFNGQGCSMIIAQNGEIIAFEGDTSYWNLDYRDNFYKCCCKWIIKDKVTVKKIKQDF
KEGKENLVTADSKKEGTRRHYFAYMPMGANGWMLCYALPEQAAQQSYNFIEDYEISFMIV
FIVLVTLLILYIVYENHTRNKELLKYAQTDALTGLYNKETTEQLTDELLSEDENKYHAFL
ILDVDCFKQINDIYGHAVGDIVLQKFGKLLKGTFREGDILGRIGGE
>A0A760RPX8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTTLHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A841PBG4|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sangaii|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTATNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRNFASEDTTPKVLLIDERKSSVERIQKMLRDRAD
LDVTSDPHAGFFQAAETPYECVMISTAFADFDPLRLCSQLRSLDRTRFVPIILLAEAGED
ERIIRGLELGINDYLMRPIDQQELTARLRTQVRRKRYNDQLRASVTQTIEMAVTDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDAHGHDGGDEVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTEGTVAEKVAERIRAEIAQAPFAIGPDGKTTEVTVSVGV
SSVLKGVDTVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A157RRT9|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MFSSRLRLRSLILASNLFFLFLALAASICATYLVKRNVLIDDVLKTNQSEAGKLARLTDD
YLRRGRDLLELVANDLSERELEPQPMRQMVMRLDRVNDLFQSLSVLNAQGVVLADSALTG
EPVTSGLPMMADLGRAPMISEPYRSSASGRWQVALSQPILSEDQHLNGYLVGTIYLHAPN
AVRTILGAPKELSAGYAYLVDRSGIVIYHPEAEREGERAINAAVDAVKRGEHGALRFTNR
RGVDMLGGFAPVSSTGWGIVVQKPAVSVLARVDEVMRRTFWYVLPVIALLVVAIVFFSNL
IARPLRQLAEAASRIEERDVGSRLRRIRSWYREAADLRRGLLRGVAALDHSIGRLRRESG
SDPLTGVLNRRGLALALEGLREQGIPLSVVMFDIDYFKRINDQYGHLVGDRVVREVSKVV
QEQIRAGDYVARLGGDEFLVVLPQTEVESAAAFAERLRNSVAHALLDSGTPVTLSLGVAR
IRDHDVDTDGLLQAADRALYHAKGRGRNRVSVMTPGGIVDGYELMASGPRG
>A0A1S8NJ42|diguanylate cyclase|EC 2.7.7.65|Clostridium saccharobutylicum|TrEMBL
MNIRKKFVIFSVLLCVIPACIATSISIENLRNKTIEIIEQNIITVADDQSSNLQDFFREN
ISNLNVIKSMPITENLLIYSNNKTNSKDIKKNVDMLNEFLISTKEEYFYLNELAVINKEE
LVIADSNNERIGQNIMLSDNDKKKLLNNQIVVTNIIEKKEVNNGIKSAIIVSPIFSEGKY
EGSILNVIDMTYFKTAIDDIHFFKTGNVSIIDGNGKIAYSNNKEFKYSINRVDSKNNLYS
QWKQVNFNSNPKGIINYNINGVEKIGYYSRISGTDWIVFSDVQWNEFKIPLNENIKTIII
TLLFIIVIATISYIFIMKHFFKPLFNLLESIKKIKQGNYSDRFIYDKDNEFGEISRAFNE
LISKIEKKRRYIENKNRELNCLTSNIPGGVHRNIIKDGEYIVDFLSGGCLNLLGYKRHEF
RKMFGRKIFDVIYEEDRERVEREINDQISKYNRFTVEYRIKRKDGSIVWILDNGRIVEDR
DGRIFSYNVTININDAKIAQEELRLSEERYRIIMSQTEEIIFEWNVEDDAISYSDNWQQK
FNIESNMSNISKKIYNNNSIYKDDLKGLGKFLNDFINGEKYNEIEIRIKNKDNEYIWCKI
RGTAMFDQNDNLFKVIGVIININKEKIESEKLLFKAQRDSLTKLYNKGTVENIIKEYMEN
SNISNKHGALFIIDIDDFKSINDNMGHLVGDDVLSNVSSMFLNVFDENAIVGRIGGDEFI
VFLKDIKSEKVIYDRADKLVNGFKAGYIENNLDYKVSGSIGIAKYPEDGESFCELFENAD
KALYLAKNKGKDNYCVFEKNI
>A0A0L6ZFC7|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MNNFYKVKKYLIYKKKYKELLIKLAQLENLNKELIKKIEDSKNIQERLQHMVYHDALTGV
YNRSYLDNFEFKEKVKKAKSLGIIFCDIDLLKLINDTFGHLIGDNLIFLTSQILKNSIRD
KDIIVRMGGDEFVIVSFDISEEETKEMCDFILKKVEAYSVENNNLPIFTSLGFSYGEGED
FCLEEILRKADDNMYKFKLSKRKLVKKKITENIINYYKIYENELYEHGKRVASYALKLGE
LFGFSRSSIERLKIACIYHDIGKINFNNNLCNGKNHSEVGYRIAKISDLLNFCAEWILQH
HENWDGTGCPLSLEGDNIILEAQIIGVSDYYDRMRYYNGLNKIDALEAVRSQADIKFSKD
LVNRFTTIFQTTE
>A0A240BXM1|diguanylate cyclase|EC 2.7.7.65|Staphylococcus muscae|TrEMBL
MIQAIIYNISVTIAGIYVFHRLQYAESHDFRFSKSYMTVLMTIVGLLLTYYPVPIAGYAI
LLSFVPILFLGRYTNAIYTFLSAIILALVGYFVLSMPLIFAIALIIIAGVASTVGPFIKY
NHIIAIQILNVISIIILLVIAWFAPNYDTEAVLYLVPLSIVTTLVTAFFYMDVHRFFRLI
ERYENEEKIDYLTGLGNVKEFDRHLNEISNEAQQQNQSLGLLLIDIDGFKDVNDAHSHQA
GDAVLKQMAHLLENYVPKDTKIFRNGGEEFSIVLRDCSLDACVKLAESIRVAVEKSSFHL
PDKTVIKLSVSIGVGYLTDDVYKSQRKVFKDADDMLHVAKNEGRNKVMFNPIIKLQ
>A0A663B2L1|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MNRPSASSTLRTPLFFIVSILALFCLINFTTTYINTITTPAPLLFYGMTLIILIFYFLIS
ITIALKYLSDKRCLFLIPVACAFIGSAIMMILALQNYSKLFYCNLNDSISYNEFLRYYFY
RNALTLTQIITAALVYRFRSHRLLASHNHIIITFACISLTLAIVLIVGFSSMHLYEPTIR
LASNIMVYMWTLLFFTTIALTRFRNIFWTGIYFYCFVYILTFSFLTTADVASENTWYKAR
LFETLGTLIFIIIIFLNAFKLYQLSNNKYENAYQNSIRDYLTQLYNRRYFYLALTKKMQR
VSVQKPLSILLCDIDHFKRINDKYGHFQGDLVIQYVAWVLQDQVRRDDIVARTGGEEFAL
LLPDVGQQQAQLIAERIRQAIISPGDVSSRVKLPESVTISIGLATTEDPKTVETELLNRA
DDALYRAKKAGRNCVVAWQKSSCTR
>A0A238LFA5|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MPDLSAVLQLVQALIAGLLASSYGVLSRRIVNQYLLSLTMGALFGMVAMISMVTPIIIGE
GVIVDLRNLFIGVSFGYFGWIGGATTLGISILVRMAIGGDGALSGIVAMTMAGAGGMAWR
QWLEPDLSCPLKSHLALGSLITLSLGGGFLLPEPSRSFLLIELGPTLAFCYVGGSVILAG
MLRREILMMKQHAALQLDAQTDPLTNLPNRRGMQNILSGVCANKNSKDAMAMLCFDIDRF
KQINDTYGHIAGDAVLREVTKRVNGCLRARDHLARHGGDEFVVLQTGLTKEQAFAVAERC
RSAVASTPVAIGEMKIDVTISIGVYWVPDYHEFDALFARADEALYKAKQDGRNVVRVYME
AA
>A0A5C6DWN6|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MFLDLAVALSCAGIGLCCGWVAHGIGWLESSDQLSVAQSSQIQLELTRARAEQERLAIVA
ERLKDNAVRMAIDVDDHQGNIQAVTDSLSSDEVASTDAVMEAVNRLIATNEKMQSKLQSA
KKQIHDQAEQLESAERRAQTDALTSISNRGAFDEHLKRRHALGMDRAGTLVLLDIDHFKP
FNDKYGHRCGDEVLKVVAQMFHARLKSYGIVARFGGEEFAVIIDGYTVEECESIVESARV
AISQQVIDYEGNDLQVTASMGVAQPLEEDTVAQWIERADAALYHAKKHGRNCGYMMDNIT
PRLISLSPEEASKSRPLPKPRRRTKSESDAEAATGETQEMENDARSELIEKDDSDAPQAI
DTAGRDEPANVDTTSEQPSPTGTMEGAPEGYGTITYGPAEEQSPADVHARLPALETLEKE
FDELQARSKALKKKTQMISLHVTGRPATGSIRALLQVVRASLRSVDRIVAQDAATFIVCI
PNSDPQMMQERAEQIRTSAESIRFGDQRDEHAESLEMKYIELESYESFERAMERLEQVGP
FAAVGA
>U9Z1R6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907713|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSDN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A378YC29|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MALGLSLPALDLPTLQFVTFLLSIATGILFMLDALRRDEAESPRWWSLAFLLATFSPVLY
LLAARSSRLAILYPLGNAVATLAFAMVWSGARRFYARDVQWVAVFGGPAVLLWGTWLFAR
PLDAWSGGVLFYALLACYSLMAAREFWQASGLRLPSSAVLAVVAVLHGGFYTARAVALVW
LGASDPVFLAWFGPQVSTTEMLVLIVVASFLMVSLGKERSEIALHRAATRDGLTQTFNRP
EFTRRAREQIRRHGAPVALLLLDLDHFKRINDTYGHPFGDAVLRLFARTAAQQLRADDIF
GRYGGEEFALFLPGVGASEAQAIAERVREAFERAARTVQGEPVAATVSIGIACEERSRGE
LSSLVQRADRALYQAKADGRNRCVRYTPETAMPSVEARVDVPPLRSAAGG
>A0A378YHT5|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MLIKCLFPPPVIAMLTTSLLAITSLLSFMMLLIVGSLLRSRVAGVREWCLANLAVLVSLP
LFALRGVVPDFLSIPTANVALAGGLLLYYAGCARFLGRPPHWRVLAALLAGLCAVMVLWR
YGFDSPQVRVVAVSAFHASILLAIAVMILRHVPPRRPPYHYWLTAGLATAFALGHIVRGL
VFGLTPAPGPDLFAQTAFNAVMLVIGSIVMPAMTMGSVLMIHDAMLATAEEAANRDYLTG
ALSRKHFDLLARQEMARALSRSLPLSIVVIDLDHFKQINDTHGHAGGDTVLREFVKLVRD
ALREGDVFGRLGGEEFAVLLPGTDTHGAIRIAERLRTQASRHLVAGPFGVCHYTLSGGVA
TWHAHESLEAFCARADRALYAAKISGRNLVLSDVLPSDETAPEAG
>A0A1S7UCS3|diguanylate cyclase|EC 2.7.7.65|Agrobacterium salinitolerans str. Hayward 0363|TrEMBL
MLPRTLSAFIRIYLKKNARMSETTDTNIFNLAPVAMWIEDFSDVKSQFDIWRSQGVEDIR
AFLLEDLSRVAACSQKIRVIKVNPRTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSE
LWAGKTEFTSNAVNYSIGGKRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKELL
NRRYAEGMFKHSPVSLWVEDFSRVRRLIEEVRDRGIVDFRVFMDVHPEFVRQCMSEIRVI
DVNRATLDLFCAPDRQVLLQRLGDIFRGEMEKPFREQLMELWNGNLTHHREVVNYALDGS
ERHVLLHFSVFPGHEHDWSLVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEL
NRLERSALRPVSAIVIDLNGLKDANDKLGHDAGDALLRRVGEVLNGVVTAPNHAARIGGD
EFAILLPGADKQVAAAMVETVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRAD
MNMYEQKNAYYAALRNRSADNNDTTKQGPQAEANSLKRLS
>H1WLM4|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MQPGSRNHQVVQTIVALSNQLGNGAIAEGIETREVLEYLQELVAPLVRAIYFLGPYLHQI
LRRIF
>A0A8F9X8J6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MSAAGGKGLPLAKRLYKSRTLGLTLGFVCVSAGMYPLDPPGWVWAWMLINAFAWPHLAYQ
MARRAENSLRAERRHLLVDSFCGGFWVAAMHFNPLPSVTTLSMMTMNNVAIGGLRFMLMG
WVAQALGIGVALLLFAPAYIALTTPAQLYACLPILMLYPLVLGWICYRQAITLARHKREL
LALSRTDSLSGLLNHGAWKDQLEIEFARCRGGQQGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKILRQNLRATDLAGRYGGDEFCVILPDMPLGHATEVMDALRDRFSSLGYAQDPT
LRASLSIGLAPYQASHDDATSWLNDADQALYEAKSGGRNRVRSVQGGWVRSV
>A0A1Y6KYI4|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MATLIKSTQLQATNFAYIELSEKTLRKQLSLLFPFAGAICAIIAFTYFVSQQGHYFTLVG
ILGMTLCYTLAALNRTLFSATILFWIFLIATTLVCSSGFYFTGARHISNTIGLTIPLLSF
FALQIRTATWYSSIFGMLYIVLSVSEIANKQMQISSALQNICAYSIIFVMAFLLSRHRYD
AILQVKRTTTNDFLTGLLNREGLLPLYQNESSRCKRYRRDISMLLINIDKFREVNDRFGL
DAGDKTLMMLAKCLRNMCAENMHIARLSSQEFCIILPDVDIQNAEQFAINIRDEISQWVL
ELTTGHKINITVSIGITNIEYQDFSYDYIKAESALMRAKRWGYNQIATNE
>V6F3X8|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MMAKMDQELVDYSGKQEAARIATNAPLHPFKLAKYFSLLSMILLLIFGGFLATFLRNSEI
DAMKRQAEERNASMTQLLGNLLVQDIESLLAEAVGKTKGELHTLASVQRLNTRITSIVRG
SEIVKVKIYDPRGLTIFSTELAQIGEDKSGNAGFNAARTGSIYSELVNRDKFSSTEGVIA
NVDLVSSYIPFVRDGEVFAVFEQYQHVDRLLRQVERSVIKTLTVIVVVFAILYILLFWVV
LHAEKIVKAQEAQLESANRDLDRRVEERTQALRESEGRFRSLTQMSSDFYWETDADHRFK
VRTYSCREAADQVLHEKSFIGQLRWEVPHFSPGEAEWQAHREVLDAHLPFRDFEISRYGV
NGNVSNVSVSGDPLFDADGCFCGYRGVGRDITEQKQAEKRLKLYADLFEQTNEAMLVTDS
DNRIIHTNAALTRITGYSAEELLGCNPRILSSGQTSAEVYVEMWAALGSNGYWSGEIWDR
RKNGSVYPKWLTISAMRDAEGVVTHYIGLFIDITERKQTEALIDHLAHHDNLTKLFNRHS
LQGRLGQALATAQRTRAPLAVMFIDIDRFKRVNDTLGHHTGDLLLIEVAARLRECVRESD
IVARPGGDEFVVVLTGMEDARDAFPVGNQILQMLAQPYHLANQVLQITPSIGISIYPDDG
ISVDDLMKNADMAMYHAKSQGRNNLQFFTAAMNAAATERMAMELELRQAIETGQLELHYQ
PQVCTHNGAACGVEALVRWRHPQRGLISPLAFIPLAEETGLIEPLGAWVLEEACRQFAIW
RAEDAPILRIAVNLSAQQLRSPGLLAQVEDVMARYQLIPGELELEVTESEAMSDPERSFD
TLRALRDLGVQLAIDDFGTGYSSLSYLKQLPVQILKIDRSFVKDIETDENDASICASILA
LAHSQGLKVVAEGVETMAQREFLAAHACEYLQGYLFAKPEPAEVCLGRLRELSIAAASP
>V6F4Q2|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MRDTGPGKRCSVSSMGVTGALLLALTFAAILLVVDLFDGRNRILAERADMALQKSQFMSQ
WFGTTIVATDYVLRDIIGKVRPDDLVYPDPDPQHFQRMQALIRDKLATLPGVEGITLYSK
DCVFTASANPKLLGFRSNQKFCTDKSELIGPEARIQYIPMDKSATRRPMILVSRNLVSTD
GHLQGGALAAIDLALAQDWISSFTVGPNDVLALVDSDGTLLARNPPLPQAIGTRSPSPPG
QPTFGETRSSANFTAISPLDGRERIFGISKIENIPVLLIVGYDKNGTLHEWERRTWQLSA
GFVILLALSLVVRRSHLRALAQREALRKLATTDTLTGIANRRQLIETGEHEVARAHRYGH
ALSVLILDIDHFKVINDTWGHPTGDRAIQNVAKAMARLVRDQDTAGRLGGEEFAIILPET
DAAGAAIMAERLRQSIETATTTQADDGTVIHFTVSIGTASLGAQESTFDSLLNRADKGLY
QAKGSGRNRVMAAE
>A0A0N0GR91|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MLGEIGDFIVTEVSVGIFALDKTYNVLVWNRFMADHSGISAENAIGRNLFELFPELPQKW
LSKKIDSVFVLRNFAFTSWEQRPYLFPFRHNRPITGGIDYMQQNATFMPVRDADGEVSAV
AVTLFDVTDAAVYQSMLKQAMAKLEESSSRDGLTGVYNRRFTEARLIDEIGRVERYHHDP
FSVVLLDLDHFKQVNDTYGHLGGDEVLRVVADRVRGVLRDTDVFGRYGGEEFLLMLPQTN
REGAMVVAERIRFAIGSETVQFNDTEIRVTSSLGVAVYVPGSQNVEEVKQQADEALYASK
RSGRNRVTFYEASQAA
>A0A1Y6L1D9|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MTDISAIVNEVSVLKQRLDLAQLSYRDSNLKSRREIVILKRLITRLFVACRGIDNELDAS
LQAISLDLEQPLEISRLIPRLSIVERLVIQQADVIQHQNKRLQHHIGLRGRTLSHYQGLP
QSLQRDLRGIFNQPSATLLDNHQRILRLLELYERSIKLIAANNNGNTLSPDQQPSFEVEL
AAELLLVISEIDFTNEQGEQLFVIREQLTQGVNQTRLQTLLLQVLRLIVAGTQAERHASQ
QFLNTLNSDLASLQKNTAKTASSFAVLHQHRCDFNTNITTMATTINQQLSLKKTPAATPL
LINIANELQQLAQRNNQLELREQALIEQLNHNDNKVHQVQQQTHSYHQRLSQQEQNIFRD
KLTLTYNRSAFDDRLKHEYQRWLRYQTPLLLMLIDIDDLSQLNQDYGHNAGDKALKIIAK
TISQQLNPTDFIARFSDDAFMLIITDCNDQQRHQMIKNIRAAVNQLPLHFKGQSVAMSVS
ISSSFFANNDTPKQVIERTETALLHAQHPRCNIVIDQI
>A0A1W6VPW0|diguanylate cyclase|EC 2.7.7.65|Geobacillus thermodenitrificans|TrEMBL
MDSYIVSLLDRMKEQYEQWESSSSLDGAELTQFFDAIGRAAKVTGRDDLAAEVERILRRM
NRQKERQWTVEEVLAEMFPLLRRCYEAEETDSTIASFLQQQGAEADILLCGNDPLFFAYI
RRSWQTVPWRFITLPSLEQAAASMFRLNPDCIIVNIGEDDLETPPFVALLKTASQPSYIP
VVIISRDGRKAVHLKCYGLGADDVIAQPVAASELYIRVHRLVEKKRKIDKLVLIDELTGV
YNRKYLPRVYVRLRSDLERFGTPSCLALLDLDHFKQVNDRFGHLVGDAVLKKLAAFLLQH
TRGMDTVIRFGGEEFIVWLAKTSTCEAHRVLGRLQRQFASEEIEAAGVRLSCTFSAGFVE
CSDPNESLDHWLKLADKALYAAKKSGGSRVEGV
>A0A5P9BCB7|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MALPKTLIRLFKPYIVLLTGGMIYLAAAQLERMENSAREQSASNIRIGNSIIRSNIEATF
GKLYLLETRLERGQTASKSAFIKLSENILKRTPNFSDIVLYHLDTKQYLSSRGLSLPSST
LSSLTWHRIDSVAEDFYISSVYQKTDGRWVFAVKHTISDRPKEIWIEFDLLHTTQGLRDL
KTLNNGYIFVVDRSTERLIFHPDPTRVGTKSISFHAGISHQLSLGQTSGQHEYYYQDHFK
VSVYDADNSLNWVFIAGTDRQDILTSSHQFTLTAIVLGSLLLLWIVANYLIHRLNLTLSL
LNQVDDIAGFKRQLKSVINHFCYNKGIQFCLYDSTSHAFSTIDYHGNKRIVHTSQSLAQS
LLPDSLIYRNGGYADSLARSLKITERHYCIPLHSRKQLLAVLYINSTFPISRSILRMVRS
ATETSLANLLLHHQLSCKDLMTQLDNKNNFNAALASHLSEPDTFIALLDIDHFEHLNNAY
GETIGDRLIKNTAEAIRSNFPKPKSLSLARMGGKEFAILFKANNENDARTQLDQCRISIA
SSTIKTPDIDLSASVSIGFSSLEGESEPALALAEQAKVIAQQLGRNRVEGYFKPISPEDS
ASSAAA
>A0A1S1HDV2|diguanylate cyclase|EC 2.7.7.65|Sphingomonas haloaromaticamans|TrEMBL
MAGEEQREVDETGAAKTGMIGHADALRRVSGEFADTALETDFAQERLPETLRYARLLMLG
SMVLNTLFLASDWRFHGTAHFWVAVPARLVTILLALACFLALRRVSTPRGATLVMVAWMV
ANALAVMLLVTSHSRIALFVVIMLPLIYYLVVPGRFWAVAACGIACSLLMYLGYGEYRAS
PTTAGGLALALLMLNSALIIVISRSNRLERLQWIAMRSERRIAAELDLSRETLARMFAAS
PIPMVITDRETGKVVDANDSYRELLGTDPMAGPGTLEPFYVTPGDRQRLLAMIDRDDKFG
DTEMQIRTADGSLRTVIVKANAVSTPHGRRIMAGIIDISDRKAVELSLEWLASTDTLTGL
PNRHSFLATARAAIAAAEQTGVPLALLMVDLDHFKRINDGWGHQMGDCALRAFATLCLEH
LRDDDIIGRLGGEEFGILLPGCDAEAALAAAGRLRQAIAGIIVDPLISDGPRLSASIGVT
IVAQGESDLEKAIGRADKALYEAKRMGRNYVVLDPLLEIPSARPH
>A0A347WAW3|diguanylate cyclase|EC 2.7.7.65|Komagataeibacter saccharivorans|TrEMBL
MGTRSDASVSHGFDDVMALAIRGSGTGIWDRDVLTGAIHYSDGWAEILGYRPEEISSRIE
DSYQRVHPDDLAYVQATMRDHFEGLTPSYEVEHRLRCRDGSYKWVMSRGRVVSRDQAGRA
LRMVGTTSDISSIRSLTDQLHQSIALMTNLTNEVPGLVFQCRREPDNTARLTYASARIEE
IYELTAAQVALNTAAIHERIHPDDREMYLATLAAATAGLTPWHCVFRVLLPVQGLRWRQV
DAHPLRLPDGATVWHGLVVDATARKRMEQELHDLARVDHLTGLPNRRAFTERMEDVWRSM
QDGASPQIVMAMIDIDHFKAINDQYGHATGDGVIRHVASVVMETLRSTDDTGRVGGEEFA
ACLHEIDLTQASAIAERLRLAIADVPVRVGGHTIAVTASIGISEMYETDVSSDDALARAD
MALYFAKKNGRNCVALATPGERGMGVEAALLPR
>A0A5P9B936|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MKVNRHFSLTFVFGFPAIIISMLLALIAKNHLDAVEKEVTYEYQRIIDAFERTTTVVTAL
DYSFSNYYKSSNPLFLDHNKTVVDGVCRIWPIDGLLLADGKTADIPSVDINYMLVGNESL
CSELSDAYRSASEKVALAPILSFLAQLDDYYFGVHFIDAKGYVISSPEDFAKGLGKELLS
TIKSRPYWQRTANNPDLLTLAGPTYRTDTLDRVISMTIPVFYKGSHQGMLSVDIDSGKLL
TSQSHLLAGQINIVDLTHALPPDDAVWIQPLELNGVAAHHMIFYQLDVMKELKAFVKTET
DSVFVALTVYLFMVMIFFYINSTIEKGYFKELAAKDPMTGLLNRRGLEAFWRNVQHDELF
VLVVFDIDNFKSINDTFGHDKGDEVIRYMARQIHNGIRSSDVGARFGGEEFVVYLRGEER
QTLKNILHRVKTAICEQSTHVIEGGFTVSGGACIVESESTHLNFDEVFKCADEKLYLAKT
TGKNKIVF
>A0A173SRB2|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKNKRRFAMVSVSVIVVALILEAGILKYVNDANAYRLSKVLLDRVVTVLNKNDQSEEELI
ESLKDDYIVRAKAVSYIVDAKPQVENDVEELQKIAKLMSVDEIHLFDETGCITSGSVPKY
FGYSFDSGTQMSYFKPMLTDKSLTMCQDVTPNTSEGKAMMYAITWNEAGTMMVQVGLKPQ
RLLDELKQNEISTVVSDMPVYKGMELYVADADTELVKGATDCDKIGKTFHDLGLPTDIKE
SDKPTVRQISVNDSGCRCIIRRGDKYIVAVTIDKSFYMTNSVVALLVVGIYLILASCCIM
YMFSKIMKEKYEKEKLLYISNTDALTGCLNRHAYETDINKLDLKKELIYISLDLNSLKHV
NDTYGHAAGDEMICAAATCMMASFGEFGRVYRIGGDEFAVIITQKPDELDAMTKHFDSSV
AEWRGKIVDSMTISYGCVRSLEEDWEFVHDIAKEADRRMYASKARYYSDSDIDRRK
>A0A509BSH2|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 3046|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A509C0N4|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 3046|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A554XKR0|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MSTLLGQLGRHPRMAAIVAATFVVLLALQAALVYVGMARMQAVGAALDEVTDVTVAAERH
SREMAAAVQQRILLMLRMLAQPDPLDRSEDAQAFEQQGLAFGRARDAWLALPKPPEIRAR
FERIQADAVALSRSQRAIVEALIGGQDDQARALFESDRVIERQRELVRALESLAEQHHGM
TEAARAEAQATQRSTQTLMIWLGLGLFALGAAIGTLVTWVIHRSEGLLHAERQRMEDSAH
TDALTGLLNRRGFEREVQRWRAQGRPGQRHSVLLIDLDHFKPINDTAGHDAGDAALRRVA
LLLREQTRPVDAVARLGGDEFAVLLRELDQAAALEVGQRIVSALGGFVFDWKGRHFPIGA
SIGAVAFDADVSSEEWPHVLKRADEACYAAKQAGRGRAVAATESGASATVAAT
>A0A6V8LP93|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MSPQLKLFLLLAPVSVLPSLAAMALLESGRERQALAVLAVHAALGLGLLPFFARFALHVS
VFKELAKVCDFAASLRRGIFPEPFVLPVEQEDENLLLRLKRSLNWMLHSLDSREKSLLGR
LAETDQARRDMEDASRKDPLTGLGNRRHFEQVLAGLPPVNGCNGASHRLLLLDCDKFKSV
NDTYGHLAGDEVLRALADIMQECLRSDRDWAFRLGGDEFAAILACSGEQARLVAERIRER
FKMANGRGCTLSMGITSCLPAPGRPANWNTVISRADAAVYEAKGTGGDAVRER
>A0A6V8LPE5|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MSNTIASLRQCMKITFPPVTLQLLEEAVKPTPDFEILARILGMDPVLTATVLTLANSPYY
NAGQKVTDLNRAATILGTKEILKIALSISYQKHLGEAFKKHGIDFFANWRLIVWSAIAAE
LLAERLCPDLSDQAYLTALLKDISLLLMVCADPTGFKELGHHGVITAFVPGQLEAERGAW
SADHCRLTADLLDELNISASDQACIAFHHDMDSLDAHSPLTQCIILATRWSELELGTSGN
PASVLHFRTALQRRLDIGPEEMDELFIRCAQRFQSMLATLGIEEAPHDDRFYQHSIKLMQ
EYHFLASEIAQASDGRQEVAAIIGRHLRFIWDVRRWELALGVPKYNDWELFASQEGREPA
RLGTSGSRDALPWTAPKSHSFPIVTSGPFLGELRLPRQGLSQETLRLLGLYVRFVSQNYE
HFALRQSVLEAKAHTLDQLPVGVARLSPSGAIQEINDRLRQFLGLPGDCLGRDLWTALGE
GKDLSRDSQWDSFLADPGATSLHKIFCLYKGEHHDTDACVYLAAEKRQWQGRDEILLFLE
DVTLVSGWEFKALKQGEFLEKLVKSMRDSVFTIDATGRITFASPRVAHLLEKNLFQLARP
TSVHQGAWGPEMLAGAPAPVEALTPGAPGEQPHNLEFVFSPLPKTPGGQKQWLVVGRDIT
TVRRLEDKLKRLALFDGLTGLLNHYQFHVILEREAQRSKRTKRPMGVLFFDLDNFKAVND
TLGHQAGDDVLRAVSRILKARLRKGMDYPCRYGGDEFAVVVTEVEPAQLMHLAQRLHEAV
SQHFEGRLGMSAGLAMLEAEETPSSLLRRADKASYTAKSQGGGCIVWSGEAPMP
>A0A8B3UCX6|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWSFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGVMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGIALTLLSALVTLPLVGKVAVFNPDLVEWGLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIVAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLEKLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A8B3UJX5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MALHSKKLSFTRPIMLSFAGILCSFAVIAIAVTLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRSAMYFARDDRLNETLNVNPTQGLQMMMHLQNLMPTVSSISLADTQGH
YLRAPEVLPTETSKTFDPRTRPWFVAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPE
GRLKGTLAFHLDLTSMGFTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSGATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRSVLMHIINAIKTGDVSEAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDSDVAELLNAQQPFAMALVDIDNFKSINDTLGHLTGDIVLRNVAREGIQI
MQPHHVSLYRYGGEEFAVIFQAEQMTSALSLLEAWRTAVEKRVWREENLRVTFSGGLGEW
HFEPLEQFVGSVDNALYSAKQQGKNRINRTSIS
>A0A653J079|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MSVGESDEGSGEPAPTIASALESLRSRLHLDQAFFVDLDGNAVGFRGALSESEREYLRQA
LDDGADSGVLRLGKLRFNAAAAPVKAPVTIGWVVFANALDERELGALAKLSSIKLAPHIV
PAGDLPKSQKIGTITEERVNGERFLVQASSIASFRSDEPQVLLLRHSVTRALAEYAPMLW
LLLASGLVGIVMAGVGSWLLARRISRPIIALDAAARRVAKGDYAQVQVETRDELGTLADS
FNRMVDDIGERERQITHMALHDGLTGLANRMLLREHLAMVLGRPAPERRQALLCLDLDNF
KVVNDTLGHPTGDALLCQIAARLVAVAGDGFVARLGGDEFAVVVDDADRPLDRIAHGVIR
AIAEPCMVNGHRIVPGTSIGIAILHEDGEDAVTLVKHADLALYRAKHVGRGGFCFYEAAM
DAEARKRRQMELDLHDAISEGQLSLMFQPLFNLAESRVSAFEALLRWHHPERGTVSPVDF
IPLAEDTGLIVPIGEWVIREACRAARDWPDHVRIAVNVSPVQFRSPGLKTVIIGPG
>A0A376F8T7|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MFFRLYRDSHVKYQQSYQNSIRDPLTRLYNRSYFYETLKQALDIAKPSRPVSVIVSDLDR
FKRINDTYGHLQGDKVLQFVANLLMDSVRP
>A0A0M7AVI0|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MFWNRKSGDIAGTTDGSRAATGRQIKIWIYGLAAMLIVLSTASLTFIAHLAWSEADRRSL
EGDKLRFTTALKQYQKLIALDQIGLAQWDETFTALQHPLNRDFIEDLLVTDLWEQFDLER
TFIVNADGSLIAQAIEDNTLFPTETTAADPIIKHLADRTRESFDARTRQASTGLADWYLP
QSVLLDVSNSAYAIIDGQPALLVAVPVLPDEGRVNWTENNPAVLINAVYFDNEFLAELNE
ALNYRDFQFFAGEPASRHPTNHLVWAADGSVLGYFRWDHEKPGLHIWFMALPLIVLITAI
IAVVAFAIAAKISRLSTSLEESERKNHHFANHDALTGLPNRHHFSDRLAFSIDNLPDKGF
ALFACDLDRFKPINDTFGHEVGDKVLCRVAERFQSHFGNDDVVCRIGGDEFIVLMTKYSN
LDELEDRANKLRTEMSAPIEIGNGETVQIGVSVGIATAPECGTNDKDLIRTADMALYRAK
ENGRNVVEFAVPRYLKKTDGDNLAGFRVQSGK
>A0A1U9Z3T1|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MNSPLKPNAEEKRLAALRKLEVIDTQPEAEFDALARAAALVCGTPVSLISLIDRDRQWFK
ANVGLEGLVETERRLSFCTYAIEGDGLLEVGDARKDERFAANPFVTGDPGIRFYAGVPLK
LSGGENVGSLCVIDMEARSLSDEQRQILSHLAEATARALEMRRAFLHENELLAAAAETQS
ILQNSEDAIVTMDMGGRITRWNRAAERMFGYAADEALGASAGIMAGDDTAAYDPYSRLRE
LGNARTIRTERRHRDGSAIPVSVSIGPVVSEDGDIVGATEIIRDISDILATQNELSQAEQ
RLRRLYQSTPAMLHAVDPDGRLLSVSDRWLEVMGYCREDVLGRPLADFMPGSSARRFRTE
LLPALASEGYYEDVEAQMTTRSGAVIEVLLSAVIERGASGEVLRSIGIVENVTYRRQIEM
ALRAERRRLGQIIEGTGAGTWEWNVITGENRVNDEWAAMLGYTLKELAPVTIDAFRDRIH
PDDRPLLDARIDAHFNGETNDFEAELRIRHKDGQWIWIATRGRVLARRSDGRPEWMFGIH
VDITVQKRREEELRLSKELLDRTGQVAGVGGWELDLVEGRLRWSKETCRIHDVEPDYEPQ
LDTAINFYAPDSQALIMAAVEKCIATGEGWDLELQLITARGKLLWVRAVGSAEYANGRVV
RMVGTFQDISEAVAQRKALEEVNRLFSVATETGRIGIWDADLVTGKTNYSDIWCELIGYT
REEVTDSGTAWQSFIHPDDMDRALAADAAHVRGEAPIFEEQFRMRHKDGRWIWILDRGLV
TERDDEGRPLRMIGTHTDITRQKEREAERLLNAERMAIAADNGGIGIWEINLSTNEASWD
AGMYRLYGLSPDTSPPLLEVWERNTHEEDAARVSGAVRRAIENDDLMDEEYRVVWPDGSV
HHLHGSARLVRGVDGGPDRFIGVTWDVTEERQLALDLGEQHELMRVTLDSIGDAVITANA
DGTIRWLNPIAEHMTGWSTADAEGEPSHRVFSIIHEESREPAMDPIRTCLELRQVVGLSE
DTLLISRDGRAFAIEDSCAPIRNGEGEVLGAVLVFHDVSEQRRLAREMSYRASHDQLTGL
INRSEFERRMYKTLDAARAGGPDSALLFIDLDRFKIVNDSCGHAVGDELLIKISRLIQGV
IRANDALARLGGDEFAAIIENCPIDIAQNIAQKICDAVADFVLVHEGKHYRIGASIGLAR
INDAAASVATILQEADAACYAAKEEGRNRVHVWRDYDEAVRSLVGQTSWVTRIEEALEED
GFVLYAQKIVPFSGTGGKTHVELLLRMIDENGGVIPPSAFLPASERFNLATRIDRWVLAH
ALEWMQSAGAGPQSVVSVNVSGQSVGDRGFHRFALELLDGASEAVRRSLCLEITETSVIS
NMAEAMEFIRALRDRGVMIALDDFGAGSSSFSYLKRFSIDFLKIDGQFAQGLLTHPVDEA
TIRCFVEMARVLNIQTVAEYVSDDKIAARLRDMGVDLAQGYAYHLPEPAAGLKL
>A0A5C6FS02|diguanylate cyclase|EC 2.7.7.65|Crateriforma conspicua|TrEMBL
MQRFGTTTRIAFAMAMWTATVLLMLRVCGVISDRTAEAIRQRSELSEMVAVTCSQMASRD
QTDAIAVTLAALVQRDSDVLSAACVADNGEVIAETVGHPMHWLADSGDVETGATQIEVPV
YQGDEHFADVQVTFRPLVAQGWLGFFGLRSVQVTLLATLGNLLGFLLLLRRCFRHLDPSR
AVPERVRTALDTMAEGIVVADMDGRIRMANQPFAEFCDSAVNDLIGKDIDDLPWVIKEDA
KFTQLLDSMASGGRESADLLRLSPSDSDERILQPNASRIIEGEQCHGYMISLADVTSLEQ
KNQQLEYLATRDPMTGCLNRRSFFEQMETHWSGAERHGHSIGCLMVDVDHFKSINDNFGH
AVGDEVLIAVSSALLEMARGSDLVCRYGGEEFCVAMPFETIEGAKLAAQRYRKAIESLTF
DQLSVTASLGVSCNALGADSVESMLDQADQALYHSKRTGRNRVTTFAELPEETDTPACEN
DVQRQDASAAEEAISGDDPVDPLDAESSLLESVQTLVRDLQAEGQSQVPLQRLQGVLADR
QAASNQIDTSVAPSGVH
>A0A0M6ZB46|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MTGDKQTETMPANGIGETVQNVRLRHFAYGSISLLLAGGVFAMAYLFMSTTQSADELALR
HERALVTEALEHSLELEARHQTFVAVNDKTAREVQIDDRIDEAFAHEIARQMWLDFHHDW
TLIVDGRNDLILVAAEDEIVPSATGQEVLDTTRDLVAKARIGYQTVRRPSADGFKVKYVE
KGKLAPIYATDVRNIDGRPALVSAMAIVPESPDLSLPDGPPGVIVSVSLIEEAFLSEIGE
TLLLENFTYVAGTGHHQASVPVSAHGHQPIGYFEWTSAAPGSKIRSTIGPIAAVLMLVFI
AIGVFFARRLAQKSRALEDSEALNRRMASHDLMTGLANRPHFHAALDRAIAQCQTTPCAV
MAIDLDRFKAVNDTYGHVAGDMVIRQVAQRLRKVLSGHALIARTGGDEFVALLRGPVDDN
RLRWLSDTLIEAIAQPVPVSGGLAQIGVSIGWASAPKHADTASHLLALADQALYSAKENG
RNMAVCIEDLYQQQQQLDQQDSRSIKRRAVRG
>A0A3U2RZK4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRNDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A377P876|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MRHIGYAPLRARQKHYFVRKNHPQMKLLAIEGRFNINQENGLSDTPATPQCSRRFTPQRI
INICFFAVFIFTSLLFWRQGQVLNNGYQASQLNRLENVSAQLGSRMQFRLDNLLFLRNYM
RYMLSQPIMPEQKRLLEAEMATLRVQDIWQTGHSHSASPPLNGIGDSQIGLLPSSDRPNN
DLWLTEINAAMRLKALLPLTNLNQALQPRIYYISRSGFYLSSTPPRDKSLISGLYTHMLA
RPYFPMAAPEANPHRKAFWSRMFDNQQDGMLISATAPVDYGDRWWGILGMDFSIKRLNYY
LQAALPSHPHSVFMLYDSHFEPITSSDTHWYRGKYFSEAQRLSLQKAVLKQSEGTTRIGT
SFVTFTRMENPNITLISLQSLRQGLQDQYGRISLTLVALWCLFVITLIGTHYVISRLVRN
METLQNRLSWRAEHDPLTELLNRRGFFDKAEEITRKGQCYGRSMAIIQVDLDKFKNINDV
YGHHVGDLALKHAADTMTLMLRKQDIIGRIGGEEFCIMLPNAVLSEAVAIAERIHAQFNR
QNLMLSDGRTVEVTASMGVSACSGTTGCSIESLQSQADKRLYRAKTAGRNQVCASDMDA
>A0A3Z3QII9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWLLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A080IUT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1-250-04_S3_C2|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LAMLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A509E1S2|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MYNIASVQGVPVDSTGSYREKYRRAIDEQERMEKQFSFQLDALKKTLYHVSAAAQGLDKQ
LDASLINLKEKMRGASGQQVFEQMERVQKAAQEFEHNRHNQNLHSAKQLNGLVEQLASLK
LPHDIRNSLEEFSQSLKKRLQSYRNYAEILDELRKLQEIALQAAANPPTGLWQRLKGGTT
IQKHTQGEATLTPVSREASDVKAELSQADMDLTPVEGEHIPAQKPVSINFDPGDEDSYQA
VAQRIARTLEGLVNKIEPNEVVRHKVDIVRLRIQRGMDWYVLAVTLEDIRDILLLRYLQN
DQDFSEYLKNINEELRSIGESLGLVVSDEGRVKNASDKFSAAVTQQVEKMRTNMEENSAN
VDLLKAAVKDHLTAIQRAVEDFNHERQQDADKSTMEEQLKALQHRLHTIESESEKTKDLL
EEQRYKATHDPLTGLPNREAYNERSYQELQRFKRYCRPLTMAVCDIDHFKKINDDYGHQA
GDKIIKLIGKILSTRLRKVDFVGRYGGEEFVILLPETTPKQGLDVLDKVRALIAKTPFRF
KDSPVQITISFGLAEFTAEDKVDNVFERADRALYRAKKQGRNCCVIYQEET
>A0A3Y0NRV9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPTDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A842HP26|diguanylate cyclase|EC 2.7.7.65|Pusillimonas sp. 7-48|TrEMBL
MLLDIFRREWALFNEFAGPGVPERVEHIVLQQADSLASQFYDTMLKDPQAQQFLDHEQVR
TRLRASLILWLTRLFGPVSAEAADDLYADQHKIGEVHARVDIPVALVLRGARSLKRAFNA
YLDRVAPDDDAFKLSACRFFGAKIDLAMEVMSQAYASSSARKARSSEAYRLFSITENLAT
EKERQKAALLDWESQVMYETVLGNASTRLVRVRESEFGLWFRHKGIHAFQGVPEADVIAQ
SIDAIDNVCLVALETEGAVDAQGRSDVVREIRNHARNIQLHLGSLFARSLELESGKDVLT
RLLNRKFLPTVLAREIEHSRKSGSGFAVAVIDIDHFKRINDNYGHEAGDQVIQQVAAVLS
EHCRGGDFLFRMGGEEFLLVLVDLDIQQAGLLCDRVRQAVQKHPFLIPDGTVLAVTVSIG
LASHTGHPDYHYLLRQADDAVYEAKANGRNRVATHASGASAA
>A0A822XAR0|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAIIAGVWMGLTGFSALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGSPVVLTSEPLALWLTLPVLVVY
PILFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACR
>A0A0U5IDY7|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MVAAPADAVGPLVENALGTVARRMGAERAYVFVLSRDGSTMRNTQEWSASGLGLGGPSAP
PVSTSLIPRWMETLQHGDDIRIDDVTKLPETWRVDREQLEQLEVRSVAAVAIRVAGRMGG
FVAMEMLSDTRSWRDSEMRALGFLGDLIGGAFERRRNEQKLLDSRRRLEEIALYDPLTRL
PNRRLLADRMDEAVARAREQGLLLGVCYLDLDGFKPINDTHGHKMGDRVLVTVASRLRGC
VREDDTVARLGGDEFVLLMNHLESLSDCAALLERVLAALAQPIQIDGHSLAVTGSAGVTL
FPQDAGDADTLLRHADHAMYQAKQHGRNRFQFFKSVKDQPDESHKLELVRIREAIEGDEL
RLHVQPRVDMGSGRVVGVEALVRWEHPERGLLPPGEFLPLMEGDELLHDLDWWVMDGALD
LLAQWQDAGLDLTMSLNLSACSLQDTGFVASLQEMLARHPSIDPARLLFEIIESEALRDI
ETTASVIRACAVLGVQFALDGFGNGYASLIDFRCLPAQVVKIDQTVVRDILRSRDDRNLV
KGVIGIANAFQREVIAEGVESAAHGLLLMDLGCTLAQGYGIAEPMPPQQLAAWIEGFRPP
RLWSTRPSVDWSTVDLSLLSMEAVHRDWVKRLIRHVLSDTATKLPDLQLASCDFGRWYLG
DGRARYGQLHAFQALGDLHGQVHRQGLRLLEIDRLDRELMAAPIATLLEERDILVEGIRS
LQVHVLEDRPRGDVA
>A0A822W8Y5|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MKAPQIPVNEAERMNALRESGLLEIDNYPAFDRLTRLATRFFRVPLAMITLVDDHAAIVK
SADGQVPATQPRDLSFCGHTILGDAPLVVSDTLLDERFADNPQVVGDPGVRFYAGFPLRL
RDGACVGSLCLIDYAPREFTAADVAVLADLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
FAQFALSVSQRRAEPLTLGWLDLDHFKTINDRFGHQEGDKALKAMATLMRSSFREADLLV
RFGGDEFAVLFADTDEPGAWIAMQYLVEQTEKYNARQLHPWSLQFSWGLSEFDHHRNDMQ
AWLKHADAQMYAMKRQHHGEK
>A0A6G4MLP5|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAADVAEQIRECIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>J4YG84|diguanylate cyclase|EC 2.7.7.65|Achromobacter marplatensis|TrEMBL
MSSSNSAVPVWTGGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFY
STLLADAEAGPRLSHEIVATRLHSGMKHWLKGLLCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAERLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVTRLDDVVLPRLMLADAQQQVSMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREIAISTRQGSRFSVLLLDIDHFKAINDA
HGHSGGDHVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGQEAALAAAEKLGAEIRR
HKFAIPEAGALRITASIGVATFDGHPDYAYLIDRADKALYRAKQEGRDRSVAA
>A0A7L5V5R3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRAYLMSHMPWLPFLLILLPANIMTMVMYAFRTERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRHGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDREHTEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWKQEEALGVPL
LTVLHLTTGDTGPLIENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSSIG
SVLVIQDVTEARKMLRQLSYSASHDTLTHLANRASFEKQLRILLQAVHSTHQQHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIINAINDYHFMWEGRLHRVGASAGMTLINDSNHQAADVMSQADIACYASKNGGRGQV
TVYEPQQATAHNERTVMSLDEQWRMTKENPLMMIAHGIASPRITETRNLWLISLKLWSSK
GELIDEQAFRRSFSDPALSHALDRRVLREFFQQTAKAVANKGLSIALPLSVAGPGSVTLV
DELLEQLEQSSLPPRLFHLVIPAEAIFDHGLAIQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMTDYLLLDAELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVLDTLSDIGVD
LIYGDVIAEGQPLESLVNSSYFAIN
>A0A377BJZ1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKSAMER
WIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDYSAA
EKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILS
WEIDIIYKILLDSDLGSSLPLS
>A0A8I0TG46|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHVNRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7B5Z8I2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAATNSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAENVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A377K5J0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKTVFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQ
VLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRGDF
>A0A8B4NF73|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTMLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLADVDLYYPGASLGI
VKVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALDS
>A0A828GSQ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPFRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQSDIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H1RC07|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGFLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRALQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A826X154|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWVALVERTDPEIRIKASEIATAHALTLSHEFYRIVRADPHAEEFLSNEQ
VERQLKSAMEKWIINVLSGGVEDIERLIQIQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PVINATDYGSMEKLHIYHFSINSIDLAMEVMSRAFSFSDSSAAKEDENYRIFSLLENAEE
EKERQIGALLAWEIDIIYKVLLDADLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFNHTLNNPKNLSNRSLRVKFLLQIRNTVSQIITLLRELFEEVSKHEVGMDVL
TKLLNRRFLPTIFKREIAHANRVSTPLSTLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASENDTLRIAERIRSRVEKTKLKAANGDDIPLSLSI
GAAMFNGHPDYERLIQMADEALYIAKRRGRNRVELWKASL
>A0A6D0IEI4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
IFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEK
ERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLI
QDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTK
LLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYD
NVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGA
AMFNGHPDYERLIQIADEALYIAKRRGRNRVE
>A0A8G8RGM1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A827UK95|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFRRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5B9A7Y0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLISDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8F9DS77|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQFQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H0XJ86|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLETAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A830VKT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPISLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A377ENP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYGSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLHWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A6D0DDL5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASMLLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGILVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNSGRGRV
TIYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H0EZM5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVLTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A479JK34|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5F1PKX4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSSINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAESW
>A0A8I0CGL0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
AAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASI
LSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIF
NQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFL
>A0A5B9AWP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTGGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A376S7X4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAS
DSVAMNSASFLSIRRRKLQHNCLNVSKNVCNISRRRKRSASLPVFTR
>A0A447XWM7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVICSSFRLASGLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHL
GDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A1C3RCB3|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MKFRFTPVVLLFFLSAVLGVSGFLLSTSYKNAQDALHFEQLDQISRTHELAQQFLNFRLT
EARRTLETHASFREDEFGNLLSHNALKKTLFDFVIRYEKSYNEDAKIVEEYGDIVVDARN
ILMKNDRWFIEKTSNGLALSYQLEITYDKSINQQGTRIFKGGFYLTDNFPLINAVRTASR
AFAHILVYDNEKLVSSVSLEDGVEDVAQASFKEFGPIFSTLDSPFSGDIKPIRIEKGNRG
LFLLSVTTTQGAENWKETFKQTIVIGFVFVVILTLLVTFVLRVLVHRSLKGLLEYAQGVC
DGDEDIHYQAGSIIEFNEVGRVIETMVDDMSEKGKYISDMVEAANSPILAWDKDGNITII
NKAIQTLFDIDNLDDFKNITDFFDRFNDPMGKLACEEALRGKATRSLETKFNLYGSTRYV
IWSVTPLRDMHNAVTGVIAQGQDVTQRRHAEGSLRLSSTVFENTAEGIMITDEKGNIIDV
NTAFTDITGYSREDVMGQNPRIMKSGRHSQEFYEAMWGDLHNKGIWRGEIWDKRKSGEEY
PKWVSISACKNDSGRLTHYVAVFSDITDKKEDEHKLEQLAHFDHLTGLPNRVLFQDRLQT
ALARSRRDKEHMAILFVDLDRFKQINDSLGHRVGDLLLVEVSKRLLYSIREIDTVARLSG
DEFTVILTDIASVDAVELIASRIVQSLGAPYFFEGHELFVSASVGISLYPMDGETTTDLL
RNADVAMYHAKEKGRNNYQFFDVRMNEHAQSQLSMANKLRIALNRNVIHPHYQLKVDIRT
GKPIGLEALARWNDENGKPVSPAKFIPIAEEHGLIARVGSSILQQVCVQIRMWQDMNFEF
GSVAFNLSAQQFRDPNLLSDIREAIEDNKIDPKHLEVEVTENTMMDDVEDAIQILSNLKD
MGLKISIDDFGTGYSSLSYLKRFPVDTLKIDRSFINELTLDSDDAAIVSAIVSMAQKLGV
SIVAEGVENIEQSQYLKEIGCYHVQGYLYAKPCAGGELPLVWEHVIREFAE
>A0A377DSX8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLLHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEV
LCALARTLESCARKGDFGVSLGRRRVCLIATKKPHWIPRFRWLKLSA
>A0A377B9Y3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAKLLVVSAVMSFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVD
PETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7W8K187|diguanylate cyclase|EC 2.7.7.65|Deinococcus humi|TrEMBL
MNALGILNDLVVNLALLIAGVTFITLTSQGQETRESAVRLLLRYSSTVFLGLFLMTHSVG
LVPGLLFDFRGVVIALAARRYGLVAGLLVAVPLALYRLSLGGAGAWPGVTSLLLVALLAS
VGTGLARRIPRYQEDTVAHRAWTALVLFGIAHIPFFPAFFLAGKPVVQTLPIYLTLTVLS
ALGLVAAHLVKQSRLQSLAQTEQLKQLVFVDSLTGALNRRRFDEDFRRTEQPAFVLMLDL
DQFKQINDTFGHERGDSVLRALVRTLQETVRSTDGVYRLGGEEFAVLLSPCDEMAVMRVA
EGLRRRVQDLVAARAGLGGEQQVTVSGRLVRLEGEKRDVLRSADTLLYQAKSAGRNRIMT
NIPLRPVATGSGTLSAAG
>A0A377MVF4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHR
AVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEY
QLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDG
VLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAW
HDTLTRLYNRGALFEKARPLAKMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHA
AGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRI
SASLGVSSSEETGDYDFEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A377F899|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVM
STRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIV
ALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTL
RISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>A0A377F9Y8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGSGVDGGFLPCHPRADGHYRVVQ
>A0A376X5F7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGQAAPVCLSRVWC
>A0A376KU85|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTTSAVVIMFSATGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376J784|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSS
IYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDT
DSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWILTALILLN
MVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQ
INDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEK
RLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A376TGV5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKYEPVSALRLFNYCLIAA
LLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMP
AIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVID
ISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSG
LYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVA
RMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTL
TDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A1X7BXB4|diguanylate cyclase|EC 2.7.7.65|Roseovarius aestuarii|TrEMBL
MQLRLKNQNEVRLFSAAITVTALSFSILLQFFMLPAAILDQVLFTSSVITIMVMTPITYF
VGLKIQDVSDLTVQLEHAVNHDTLTGTCTRLSFYRRLSEMDDLPLVIIAADIDHFKKIND
KYGHKAGDGALKQFANTLSRNSREEDVIARFGGEEFVVLLQGMSLEDGVVTAQRLCDQVR
KKVFIAEGQQMRLTASFGVAEASSISEVDYAIHQADLAAYRAKRDGRDRVYTYNPELDKD
ITWAETAT
>A0A7A4FW04|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENSEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A485E2C3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGLGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6D0DWA4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376ZZK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MGILKVMRCYAPSPAPLKVALAKAIWVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAK
VSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5E4UF46|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MEFVTKDVLASCMALLLDAVFLVDKAGALVYVSPACERILGYTPEELLGRSMIDFVVKED
RERTIEESKFVMAGLPRIGFENRYIHKDGHYVHIMWSARWSEDHELRIGVARDVSAKKQA
EALQRATYSISEAAHDAADIRSLCKAVHDTLATLFPIDAIVVATCDAALMTWEKAYQYRD
SADIPLLDWPQARGLSTQAAQAQQSLWHLIEAIPIDGAGQSIPHLCTEPFAPDALAEPGA
QALVILPMRTARRAVGTLMLYGPASALRAEAAQRLLAFVCDQTALAIERKQLIDDLYKAA
RFDELTGLPNRRTFGEFASEAVRRAQRTNGKLALLFADIDGFKGVNDSLGHAVGDLLLKE
IGQRMKAGVTGGGFVARHSGDEFVAIVQDAEVVERIDVAVTRLRAEIEQVISVNDASLSV
RVSVGVAVFPDDGESMSELIRVADQRMYANKSARKSGGSSFLQHLI
>A0A379KIS0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MDNRSGKGLSFVRRIYLPRMIGLGIGLFSVAAAVAPLSPPTWAWLLLLFNGLLWPHVAYQ
WARRSIAPYQAEQRNLLLDSLMGGFWTAAMHFNPLPCVTVLSMMTMNNVAAGGKRLVMRG
LVAQLVGMLLASALLGTGLQLNATPLQIFACLPMLTLYPLALGWVCYRLAIKLAEHKRRL
RDLSLTDSLTGLLNHGAWKDLLLLRFQACQNLQMPSVIALIDIDHFKTINDTFGHVVGDC
VLRKMSDELRRNLRAGDLAGRYGGDEFCVILPDTSESEARQAMERLRERIVCYRDPQLPH
LKISLSIGMSAFRADLQSPEHWLEKADKALYCAKRRGRDQVNFEHDETTALQPVSQAEYP
R
>A0A399U874|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. LPMIX5|TrEMBL
MQPSFPALADTQDAAQFGVADPASVRRLRQLVQDHAEALVAAFYDALLAHEEARAFLHHS
VVQERLSPSLRRWLIDLFAPEVDGDEAAFVARQVKIGEVHARIKIPMHLVMAGAAVLKGR
LADVLACDPAAFDLLRLSGERIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFER
ESQRAGLMEWSQKTLFRILASGGVEGAGALSASPFGLWIRHRADFLFDGSPHLARLNAAM
ERIDGELLPRFTPGAASSELVGPLEALEAAVDEVAFLLNEMFQGLAGMEGGRDPLTRALN
RRFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPIGDEVLRQVAEAVTENVR
PSDFVFRYGGEEFLIVLVETGLRQAAIIAERMRQALAAKAITASGLAPFHVTVSIGAAEH
GGHPDENYLVKQADDALYRAKQNGRNRVEIA
>A0A109CGN4|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MKDDIRKTKGQLIEELSQLQLVSVEHKILAARYKAVIEFANDAVFVADIETGIIIDANLK
AQELTGYSREEIIGMHQRQLHPAEVLDEKGEFSKSFTRHVINTHAVEEEKIIRKDGTILD
VSISAGVIELRTGKLIIGIFRDITEQKKIISELKRHQEDMKKLLTMLNTTNHIAKIGGWT
LTPGTMEVTWTDEVYHIHELPVTQPPEFVKAMGYYPEEVRFLLIDKLQECLTTGKTINIE
LPFTTAKGNHLWVSINAIPERENGNIVRIIGSFQDITQRKQMEDLIRKNPDIIERHETEQ
DNNGN
>A0A1R3TIY5|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MTERLREFISLEVSLTDLGEGQDLRGFTTKMVFISIILSLLVSCIVIAVANFLNLLPLPL
LEALIYSVAMAWIVGGVVTGILCWVVAGAIRKLHASHAEFERLSRTDTLSGLANRRAFNQ
CFDEVESDASLAIFDLDRFKGINDNYGHAAGDVVIKRAAAAIEDVFGEFHCVARLGGEEF
AVIVRGGIRKDRRTLIELARIRVSCLTINYNGTQLQTTVSVGVADIDPCRSKHDTFAVAD
KALYLAKASGRNRVCHEDELCVAQAVENLKSTLLAAS
>A0A1Q9RA65|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MTFKHIDLRKIILLFALVTAGVTLANSFYAARQVQHQVLVDNALEANRAYAAKVASSIEA
FLLSAQQQLAYSVGQMSRDFGDPRLLHAEAKRIQEQDQGFNAITIVDATGHVLAAWPPSL
LHDGQALTSSGAEHALNSRVPLISDAYTSSTGNLVVFISHPVFDDQQRYLGFVGGAVYLR
EKGILHTLISNHFYRDGTLSYVVDNNRRLLYHPQFDRVGSVVGANLAVDELLTGKSGAMQ
VVNTQGVEMLAGFASIPLTRWGVVSQKPYRDTVAPLDRLMWQMFRGTAPVGVLGLIGIWW
MTLLITRPLRQLADNANAMNASSSPERIRAVRAWYFEADHIKRALLRGINVMQERMGRLN
LQAQTDPLTGLFNRRALGEALEVMDERKQGFAVIAVDIDHFKAINDGHGHDVGDEVLARL
AGVLRECSREGDLAFRLGGEEFLLLLPDTPIAAAGEMAERLRGQVEVTRIEPVGHVTVSL
GVARCAAGDDSHAALKRADELMYRAKQGGRNRVVLE
>A0A636P4W6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Guildford|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A168R5F9|diguanylate cyclase|EC 2.7.7.65|Clostridium ljungdahlii|TrEMBL
MYKYKNCIFEVIILLIVIAALYMTNLYSYLLFHSLAELFSVIIGFTLFIVAWNSKNFSKK
YFDYLVFIGIAYMFVAFLDLLHTLSYNGMNIFRGYNFYANQLWIGARYLESISLLIPFIF
IHFKRKLRPYLTFAIYTVVTLSIIASIFYFKVFPICFIQGKGQTPFKIISEYIICGILTI
DIILLRKNKNKFDSKVYGYLFGSIIFTIISEFEFTLYINNYAFSNLLGHYFKMISFYLIY
KAVIITCITQPYNTIFKELTDKENELEKTAATDEMTKLYNRRAGMEFLDKEMKNVLRNKN
NLTICFIDVDNLKKTNDTYGHIEGDNLILNVVKLLVSNVRNSDYVCRIGGDEFLIIFPNI
IIKEAELIINRIRSDMDKLNAGSSFNYKVDFSYGFAEYNNVKKVDIDTLIETADNNMYKN
KVQKRKITE
>A0A5B9QZS0|diguanylate cyclase|EC 2.7.7.65|Roseimaritima ulvae|TrEMBL
MSGTPNHPIQPSSDCSPTAAGSGLLSQLGSATPALSPSGLVDKTPDEVIENRLAMVRLGM
ATALYYALRTKHPPTAAHSLRVAISCSVWAERLRLPAETRDRIEVAALLHDIGKIGIPDN
VLRKPGKLTVSEQLTMELYPRLGCEILSGCTNDAELLSIVRYSRAWYDSRRDSDAPRGQS
ICLGARMLAIVGAMDSMTTDHVYRPAMSHERAMAELLAGSGTQFDPELVHDYCRMVETQS
ETVPNQVITRWLQQLSDTRTDGPWGVTVGNRVSVANPPASDDRHQLFHSQLFDHMHDGVI
FVDADRVVIGWNRAVERLSGVVSDAVCDNLWAPELIDMRDLHDDPLDDASCPLFQCLQSG
VYSSRHLRIRSADGEPLPVHVHVSAVTGGQSEVLGVMAVLHDASRQTSLEERLVDLHEKA
TKDALTGVDNRGQFDRALAELNELASAGGPTFSLIICDIDHFKQINDVHGHQAGDDALVS
FARVLKAHSREGDIVCRYGGEEFVVISPSSDNPTATRRAEAIRAAIEQTPIESLDNNTMT
ASFGVTEFQSGDSPETVLARADRALLRAKDGGRNRVVQLGAGRSNELEDSTNKPGRLASW
MSWFDSTDHSSTEVRILTPVPTDLAIEKLRGFIADHNAEIVSVNDRKIIVRLNVLFSAGG
RRRVDHRIAFEVSMQLSEQHQQVPNASVKRTQTIVDVHLRPIRNRDRRSRELSACVDQVT
ASLRSYLMGTMVAPRQDH
>R4YG87|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis SB3432|TrEMBL
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGDNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVITHYSQALS
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSASGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TCYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQ
GREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADGRPYLAKQNGRNQVCFRSAA
>A0A8F7M4D7|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MEEWDPEHFTSFEHLCEVTLSAVREKTEAEQIYLWLRAPTPQLYHYRPEQGLLCLNADLL
GSLELPMLFIERSLELGQLLVEPIAPTHVIWESVEPEIPRLRACFPLKRHKGLEAVVYLE
TRRRLDRLPRRQQQSIQLLMHYLAAELESRRLAGQVDLERDQRLHTQADLVRSQALQDSF
LSMLQALHQVGVKLARCDSEDRLLHDAVALARQDLQFDRVAIFLTDGDVKTMHGTWGTNE
AGELIDERHFISPIPDHPMVQEALRRKDYVLVLEDTPLYYEKQEVGRGWNAMVSLWDGST
PMGWIAADNLLWRRPLKAYQSEIFKQYAAMLSQLLIRQRTQSALERFNRELEQRVQERTR
QLADTNRALEEANRRLSLLSLEDPLTGIANRRQWDITMEREWERARRHQGVLAVLMIDVD
EFKSYNDHFGHGKGDQCLQRVAALLQETERRRTNLVARYGGEEFVILLCAPQPGEAERLA
EQIHQGLEALQIPHPASRVAQRLTVSIGFSYRVPSADKGWQTLTEQADQALYHAKSQGRA
CTLAYR
>A0A840GFB8|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. CIR18|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDID
GFEVCRRLKSDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRPSSYERLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQASTRGKPLALMILDIDFFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>A0A0M9EEE5|diguanylate cyclase|EC 2.7.7.65|Shimia sp. SK013|TrEMBL
MQAEKREILTKVAAVTLFVNACVIIVVGVLADRDDWVSGLPVLILLASVLTIGISWSLGH
LMQKSQALSSELKRLENHDKLTNVASREFFFAEMERRPSVQGVILMVDLDRFRSVNDTYG
HLVGDTVLRDVATILAGNIRGEDLICRFGGEEFLIFLNRQNETTGASIGERLRAVVENRK
IPIGTEEPVKVTVSIGAARMDSINDLKTAITAADQALLQAKSRGRDRIVVSWSDGDINAM
EDVA
>A0A839FKC6|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium sp. P30BS-XVII|TrEMBL
MTARILVVDDVPANVKLLEARLSAEYYEVVTATNGYEALEFCENNSVDVILLDVMMPGMD
GFEVCRRLKSQPHTAHIPVILVTALDQDMDRITGLNFGADDFLTKPVNDLQLLARVKSLV
RLKNLTDELRLRVATTRDVGLESILRFPSGIETIGRDARILLIDERPASAERIRSVLSPE
CVVDVQTDPQTGFFDAIQGNHDCLIIASSFAAHDPLRICAQLRSLDNTRSMPIILVADPG
EEPKIRRALELGVNDYVVRPLNSNELLARLRTQLRRKAYHDGLRASVVKTYEMAVTDSLT
GLHNRLYLETHLATLFKRAIDRRRPLSILMTDIDRFKLINDTHGHDGGDEVLREFARRLR
RNVRGSDLASRYGGEEFFIVMPDTDLTMAAIVAERIRREVASTPFFVDDGITSVPVTISI
GIASVQSKDDTVQNMLKRADEALYGAKASGRNKVVSAAA
>A0A1F2PHN5|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MRQLITINHELHEKWRQVLFRTCIYIGVIIFVAEFFIFVFNKHDQPFSPVIIRYLIFYLA
LPTFLNLIFIVGAYFILKSEKTSEKAKNYTVALLFFLICACVQCFHYTFPAILCVPCIAV
FITVIFLDINLTRLIFGLSYGSLILAFLIARFEADRAVEVIFLDCVVAGIMIFCAYLVAT
VLTRYTSEQAQSIHDSYLKQMELIQEAKTEPLTGLLNRRAMVDVLGQAVYQDAESRKPLI
MAVIDLDDFKKVNDTYGHRKGDEVLITLADILKRNTPGNENVFRYGGEEFVVLFSGYPIG
TVVGLLDQMHQEFSTHDFNFAAGERITFSCGIAEYTDSGWSTSEFFEKADQALYLAKSEG
KNQNRIYEKRLEA
>A0A3S4P341|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MSNDQSAMNELHWLIDMVQTIEVGLVVLDRDYNIQLWNGFMENHSGVSPNSIKGQNLFTR
FPELPATWLKQKMESVFMLKNRAFISWEQRPYVFQFKNYRPITGRADFMYQNVTLLPLAS
LTGKITHISVIIYDVTDIAVNKLQLKAANEQLERLSQTDGLTQLHNRRHWQQCLEHEFDL
HARYSGMSSLVMIDIDHFKRINDTYGHVAGDKVIQHIAHILSHSLRETDCVGRYGGEEFA
VVMPNTCGADALNFTERLRERIADSTIVYEGLKIKVTVSLGVCEIGKHITSSSGWISCSD
KALYEAKQKGRNCSVLHTEQTSGY
>A0A8G0T369|diguanylate cyclase|EC 2.7.7.65|Roseovarius sp. SCSIO 43702|TrEMBL
MKFATDLLRDLPRLVSSEEAGGVAIVGMDGRLVDASPELERIFQMPRRDLLRKSFRDVTH
PEDLLRDDAHFERLVAAGTGSYSLLKRYRRARGDYIWCELDVTLVSDPSGAASHIVAQIR
PTTVRDSTLNLLHDQVLHDPLTRLLNRTTLLDQLETSLHRTRRTGVSFALAILDLDGFKA
INDSHGHDTGDALLRQVADRLRGALERPDLAGRLGGDEFAFIFRDAGDPATLDRREARLM
AAFDTPFRIDRAGEVTLGASLGRAVFCVHGTTVSDLLRHADHAMYACKRTRRALPKVRVS
G
>A0A8G0TWS6|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MAKVSRFLLFFLGLLTSVTSAAALLHIDTDTPTPLNLTPWLQVSHPSTTQLADIQNLSKQ
EWRNFTNKDIQKLSQHNFWLNISLNSTDESLSRILALDNPLLDKVTIYHLINQKPFNVVY
MGDSLPYSERPLLSNIFLYPFKISANEEHTFYLHIETEGSAAVPLYLWSANDLAQIAEST
AVEHGFQLGVLAAIGIFSLFIAVASGSFSYSYYSGYVLSMTLLVATINGFAFRFIWPEWP
MLQQIMVPILLPVVMAFALMFTEKILQLKYYNRHMLLICRYSAVYILLVGLLLPFIHYGT
ALYIEIISVAILSLILMVLAIMQAINGHKLARLYTIGWVSMLTGACISSLLYLSVIDLNM
KPQTPVMLGLTFEIIFMSLVLAIRYNDERKAKLRIQQEALKQAQKIRSAREEALKLEAET
NEKLEQMVQERTLELEITLRELHEVNQKLTEQSTIDSLTGVKNRSAFDKRLLAESRISRR
QETPIAVLMLDIDKFKSINDQFGHLAGDQALKIIAQTLQQNLKRPTDLVSRFGGEEFAII
LPNTTADGALQVAETIRDAVTSIGLMWEGKPIPLTVSIGVSADIVASDQHSTTLLEQADK
ALYQAKNSGRNQVKLYSSATAEPN
>A0A1C5M7U2|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MQKIKYDKVRQLDKIVFLALGLILVALVIQMAILNWINNRNISKMSEVLLDRVVNVIEKN
EQDEKDMIASLKEDYIVRAKAVAYIINANPEAEKDVDELKKIAKLMAVDEIHLLDATGKI
YSGTIPEYYGYSFDSGEQMEYFKPMLEDKTLTMCQDVTPNTSEGKKIMYAITWDETGTRM
IQVGIEPVRLLNEVKQNEMSSVVTNMPVYEGIRIFVADKESGKIYGATDSSDIGKKLDDI
GITKKGDEEGKIFTGINEIDGENYRCSFYITGDYAVGVACSNSSNAESNAIALLIVGIYL
TLAAVGIIYMYVKVNKAKIDELTGCLNRRAYKDDLSGISLASEFVYAALDVNGLKGVNDT
LGHNAGDELIHGAAECMKQCFGSYGKVYRIGGDEFVSIIFVDESELKKIREDFDEVISHW
SGAMVNKISISCGYVYSREKNWESFEEIASEADIRMYEAKEKYYSVEGRDRRK
>A0A0M7CNW7|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MTLNLSATQVLTLGSPAIALVISGSFLCIWKFLDRRAYLALLAGAFLLYAAGAAMQILQW
PQDRDLNVTIPAAIYLLSIACMTEGLLRRYDQHAGYPLALACLAIWMAVAYFCYVAPDAD
ARSYVLNFGIGAILCTAAWRIRRARRASHIDKTVYWVFALFALSFFARTLLTLALPAYFV
PQVFGSLAFWFILQLTLVLTGLVLALLLFAASLADMITRLRDDRDLDGLTGLWNRRALDE
RLETLIARARQRPYALLLIDIDHFKSINDRYGHAVGDHVLRVVSSLIRDCAGDDALTGRV
GGEEFAIVVPAELSAAYLLAQRLSRVLAETRIAELDENHVITASTGLTMLQPGDTVSLWM
RRADTLLYQAKRDGRNQVVLQSAAA
>A0A853W249|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MLTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVDEGKLVGIITSRDVRRFHPNR
LVADAMTRKVITISPTASLTEAQKLMVKNKIERLVVTSENNIIGIITYTQIMLELGKYTD
SLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKEYGHIYGDNVLRQATIILKN
LINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
>A0A1V5W9B5|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin218|TrEMBL
MIQILNKGVMANFCRSLFFIIFLLLFNCKLFAAYSGNVLILNSYYPDYRWANDEFRGITS
VLDNQPSIRYYVEFMDSKRIRGDEYFRYLKYIYNLKYSSIKFDCIICADNDALNFLNKYH
SSLFKGVPVIFCGINNYRPSDVTGFKDFTGVNEAISIKETLEIAFAFLPEAKRVFVINDA
GDTGKRLKSRINDVSDKYFHGSPFDFADGDLEKIFSEVQSSSKDKVVLYTVFFKDTKGKN
YGHTSLLDMLRGVSHVPIFGLWDFHLDRGIIGGKLISGFYQGETAAKLALRVLSGEKASS
IPVIMESPNKFFFDYREIERFAIDESLLPKDAIFINKKQPLLDFYKMHKNAFIIITATFI
LTILFFLTLFVIRELQRRKEIISSERLLREIINSMDEAVYLLTPEGILLECNEEGKRRVK
IDSFERGKTNLMSFFPPEVTAQRLEYMKLACDTGLPVTLTDKRNGLILQNSIYPISNENG
KVDRLCVVSYDITSLKQNEELLNTIISDAPIGLLYTTTHGKAVLSNSVAENLLNIKKDES
TGLYCKAEEGSYSCFLDEDKFMSLLSEINTTGRNIYNHECQINSPDGYRHLLINAAPTRD
INEVISGIIFMILDVTESVNLRKELEESKDKITMILESINDGFFVVNRDGIINFVNARAL
EIWGLKSEEIIGRPAVEVFLPKYFSAVYDQLEITLRENIFTKVEHYQKNTKRWYLLHLYP
YKEGVSIYFTDITYRKELEEKLKEIAHKDSLTGLLNRRAAIYFLEKAISSSLRDKKALTI
AFIDIDGLKKVNDTFGHNEGDRMIVDVCKIIHDVLRESDVLCRLGGDEFMAILPGCTMEQ
TLFIKRRIESGLDAANRIGDHPYRLDASIGFAEYPHDKKISAEEFISLADEAMYKVKMAK
KAGRA
>A0A3Z0CG61|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Haifa|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A554WGI5|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MAVDARLRPGWEATMDWSSLRLDHVRALLRQAGVVLPPPEQPPTPRDVQAVLDALCELSE
HDALTGLPNRRAFEARAVQELDRASRAGETPLLLMVDLDHFKRINDEYGHLAGDTVLQAA
ADTLRGTVRPMDTVARLGGEEFAVLLPNVTPARAQALAERLRAALQRAVTVPDGRTVAIS
ASLGGAFAPPWVRTTLANWLERADRQLYEAKRGGRNRVMIEPLRHDEVSAEEKDMLYGLL
GGPAPSIAGAEQAEPDVT
>A0A5R9L8J3|diguanylate cyclase|EC 2.7.7.65|Klebsiella indica|TrEMBL
MNKDLSQAPRPTFKRALRRISMISVVISMTLIWLLLSTASVFTLKQYAQKNLELTAATMG
HSLEAALVFGDSSAARDTLAELGKQGQFSRAVLLDKQQRDFAAWNNDHLVSQEKISDTIS
KWLFPEPTVQPIWHQGKIIGELRLTALDKLISHFLGIAIVVLTGSIFFASCIALLLTHSL
HRGIVSALQNITEVVHDIRKNRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRSSLLDPLTGLANRADFCNAITALMKDKTRHNCSALLFLDGDNFKRINDNWGHAA
GDNVLIDVARRLMAFVGKQHQAWRLGGDEFAILLRGVRTEAEVQVLCDALSEQFLPPFNL
QNGHTARLSLSIGYALTWEHDCAETLQELADQNMYRMKNQRLQQTQK
>A0A1J5N514|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MLVIELDIRTLSIITVVFSLGFGSGLVAFGAARPILSGLKQVGFGMLSIGLAFLLIGLRH
RIPQAWSLVVANSVLVLGFMLMNRGIQGFREIPRSDTWPTAAVVVFNTLSLLYFSYVEPS
FTQRVFWVCLSLSALSGICCRNVIRRGTINTMMPQKVLALGFGLFGAFMLLRALWALDEH
ALQDFMAAGTIHQLAFLAMIMLLVTVAFGLIWLASEYLFQELKQYERIILTSPEGIVLVD
ADGRYRMANDASLKFVGLHREELLGKRSLDLYGKEFYETVTLPNIRKAFAGETSATSSWV
DHPDGGKVYLTITYYPVPDTRGRNSFVAIHIKNMTELHFAQKEKQRIFDLSLDMLSVIGM
DGVLREVNPSWTGTLGWSQAELLHSNWADYVHPEDAPKTRETEDALKRGEPVVDFVNRLR
TKDGLYRHIAWMASPDVENRLIYCVARDVTNRVSREEELFVMSTVDPLTGAHNRRFFMEK
LDEEVERGQRYGTPLSLLAIDIDHFKKVNDTYGHSVGDKVLQRCVDTCKQTLRSSDTFGR
LGGEEFMAILPFADHGTGHDTAERLRLALSRCTHGGKDGLPPFTVSIGVVQLERDDTADS
LLKRADEALYRAKENGRNRVERG
>A0A1J5N1I6|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MIAAFSLISMLTGGILLYRSSLKIIRLYFYVSFACLIGRCLYEGSYQYYLLLVPLLIMLV
LIHQLLKTQFSDYVENIARRIQYERASQADPLTGLANRRYMDAFMEKLLPISKRSNQEFQ
VSMIDIDHFKKYNDTHGHIKGDELLINLSHLIKRRIRSGDLFVRYGGEEFTLILAGCDQD
SAKELFEEIMVDIKEELGVSISVGLSSSHRSNDFYQLLELADDALYSSKQNGRDCITFA
>V5DVD8|diguanylate cyclase|EC 2.7.7.65|Methyloglobulus morosus KoM1|TrEMBL
MPLLIQELAETELLRQVSDDILKQVLAHAEPLGFSPGEVLLSPEQDNKHIYLLLSGTLTV
HFDSPDSPVIREITEGFSVGEMSIIGDTAPSAYVKAKGFCRVFPIHRDFLLELIHNAQPI
AYNLLRLLTQWMKANTQKIINDQVQISELTNQANIDGLTGLYNRRWLDNALPRILSQMIG
IGQPLCVLVIDIDYFKKYNDLHGHQGGDIALIYMGNVVRSNIRPYDFAARIGGEEFMVLL
PNTNLTVGIALAERIRQETENQVIAHPDGAAMPSITVSIGIALSDASSTSKSLFSAADKQ
LYSAKQSGRNCVKY
>A0A1W1HU61|diguanylate cyclase|EC 2.7.7.65|Nitrospira sp. ND1|TrEMBL
MIKLLLVEDNPVDALLTRDLLAEWPLDQFEITHAPILADGLTRLGRDRFDVVLLDLSLPD
THGLSTVTQVLATSPGVPVVVLSGHDDHPLALKALQHGAQDYLVKGEGGTDFLARSILYA
IERKRAQERLTYLAQHDQLTGLINRALFRDRLIHAMARSKRKDHPLAIMLLDLDRFKAVN
DTLGHDVGDQLLKLVATRLLECVREVDTVARMGGDEFTAILEGISGVADVLVVAKRIVES
ISTPFEIGPHRISIGVSIGITLYPLDDEDIDELLRHADKAMYAAKQQGGSRFHFHSTTGQ
PPSGTPAPVQ
>A0A8B4DVW3|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MRNPPYVETGYQYDLVTNALRDTGQLGRLKTGIGLLCFVIVFLQGVTQFYPLGPHGTWPR
VVHGITAASAVVAGLWWLSFSWPGRRAMAAFVVWADVALAVGAALLSDPTARICAIVYLG
PVGLLPTFFLSRRALVAHCAFATSLLGALLAVNVLSGGARMFEQFFYAAPVISAIVLVPA
VIQLVLEGGRDSILSAALAADRDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDVDG
LKELNDTHGHGAGDMTLKAVADMLRARTRVGEIAARFGGDEFLVVAFPGRGEDIESTIRR
VSAPRAGVDYWTVSVGAAWQSRTGSKVDLESLVQQADHSLYEAKQTRGMLDPQR
>A0A1X3IZI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA447|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>G8LI03|diguanylate cyclase|EC 2.7.7.65|Enterobacter ludwigii|TrEMBL
MCVQRETFVVRRSFLQWLHMRSNPGLIVNLCFLIVLIFSTLLTWREVVVLEDAYISSQRN
HLETVATSLDRQLQYSVDKMLFFRKSMRDAIQTPLAFDVLYEAISCFNAFRTRPSWQLAV
DKKRTLPINGVSDAFVEKTTLLNRDPERISNEISAALEVGYLLRLASSVGQSEERVIYAS
RAGFYLATDAPEQTSDISQRYYYLVTQPWFTQQSERNNRARAVRWFISSPSPWTGGERMI
TASVPIYFDHYWYGVVAMDFSLKTMKHLLEEATQERTEGEYQLYDTRLNMIATSEEAGSL
VNRFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVILRVHTLHEGVKGDFGSI
SIVLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKM
LSEKCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIGSALRKNDVAGRVGG
EEFCVVLPGSGLEEARGIAERIRSRINSKEILVKKSTTVRISASLGVSSAQEKDNYDFEQ
LQSVADARLYQAKQCGRNRVFWHDQDKK
>A0A0T9N4C6|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MALHPASFDDHLFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYKAEEIIGQSFELF
YTPEDLANELPAKGLRHTNQFGHYEIQGWRVRKNGKRFWGHLTLSALHDSDNNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTNGRILTWNKGGERHEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVTTWNHGAERN
IGYASNEIISQHFGCFFLPEDIAAGLPEKLLKTAASSSRVEREGWLVRKDMTRFWAVTII
TVVHDNSGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEEIFILWSPLQDKNQLVAINQCLTQGRNTLLPE
GSQLLSSQGERQEIRCSISPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAITQLGKDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLLNCPNKAATEVLETVVADIASIQFHWHGQSYSFTASLGAVSL
TQKTETAAQAMRQADIACYAAKHSGRNRLSLAL
>A0A178XBB2|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MSADDELGTGETAPDLLTLHESIADLFATRGDWRRAYRHLRSALDIARAGSLRDPLTSSY
NRRYLDQRLPELPAAVAVALVDLDRFKSVNDTYGHLLGDRVLCRVADLLQEGLPADAFCA
RYGGEEFALVLPGIDHRGAVRVADAARLRVARHPWSELRPGLRVTISVGLAHGTGSGPRQ
LHRADNLLYAAKRAGRNKVAFHDRETAQVITHSE
>A0A5P9EGW3|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MPQSAEKFLPGRLSRAGFVALALTSAAGIMLGEFLLAACAAAAAGISLASNPRFTSHHAR
LWKHFKTASYSILAILLLVALWQGPWALSHWLYALPLVTFALMPTYIAALITALLTFAIL
VSTQWAVILPDRHQMISAFVLTTLLSTLLIFLREYKARQLAPLRRTDELTQAASREYLSA
DLHKEIQRSEREGTDMSVMMIGLDTHLSDNDPDEDIRAILPRIGRYLHSQLRDFDTYYRV
ADLQFLVILPGINTAGAAASAEKIRNGLCKLLASHGMKLTVSTGIAGLNIGDDADSLQHS
AANALRRAQQQGGNRTQAYSNWLHPDVQSPTGTEGDAR
>A0A2I8TQ51|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii complex sp. CFNIH9|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDNRMTTTFSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFTLAMLDIDYFKQINDNYGHNTGDMTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDKSQASIILETLRMKIAGMCMAASAAESFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRIEVYQE
>A0A0Q0MKM4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MAADLEMNEIHWLMDMFNTVDVGLVVLDRDYKVCVWNGFMENHSGLLPSAVKDKDLFDLF
PSIDEKWFRSKSESVFVLKNRSFTIWEQQPYIFRFKNYRPITGKADYMYQNATFIPLTNT
LGEVSHICIIIYDVTDVAVNKKELEDLNKRLEQVSQTDSLTQLYNRGHWESTLHQEFLRV
KRSGGSSTLLMFDIDHFKKINDEHGHSCGDEALRHLSDLLRTTLRETDIAGRYGGEEFVV
TLLDTDKQGAATFAERLRALIEANPFVYKHTKIEMTVSVGFAGNSPEFAKHERWIEAADK
ALYYSKEHGRNRVTDFEDIKNDA
>A0A7Y8PRL6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SwsAc5|TrEMBL
MYQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSNTEQVGTITDR
IYQVDELIEQIKNSESQSHAVEMIQLIRAKNREILHLIDQIFQVSEYINSGNDALTQLLN
RRYLSTIVAREINFARKNNTPLTVLSIDADHFKYINDRYGHAAGDEALQFLADSILQYTK
GSDYAFRIGGEEFLLLQVDTNVERALKVAENIRKRVADRTVNTSTGASFNFTVSIGVHEY
DGHPDYQRFLDAVDKALYVAKNNGRNNVYMG
>A0A0Q0GUX5|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MAVAQEKMTNVCLFLERHTLPPSPLNYHVAYTYISKVNTELNNTIDEAITNKAHIDSIFI
EQLYFEFLNEGHTTQVAMINNVNGVIDSLSRNAQSTEKQITSFAGQVSECMHSLDENNIE
QSRQALDTLNTQSATLLEQHKHFKHELLKAKKLHEKTQKQLAQLRKQHIIDSQTGLYKRH
YLTQQTQVWSRQDKSICAIAIQIDNLDHFVDNYGDIIGEVILNKVAKQVKKYVFQSGLPG
RTAKDQFTVLLPDIDPETANVIAEKVRNGVEKLRFVSSKSGTKLPGINLSLGIAQQLKND
DFNQLAKKASQAAFKARSLGQSSFTAGH
>A0A2H5ZWL0|diguanylate cyclase|EC 2.7.7.65|bacterium HR32|TrEMBL
MTTTAPGAAPEARPRAYRVYTAAWAAAGGVLLVFALPAAAQFPPGYLLFLGLALVGNLFF
VPLWGGLRLSLQVTLAPVWLFGWQAAPPIFLLSAPVAMRSLRADRDRALLYFGNGTVWTS
AAGALFQAVHPSWSPVPTWHDVASVLGSGLVFVVGNLATAAYGRALATGDRSLLQPGRFL
ATAATVFACYVPLAYLLVLTFQAGPAPHVLTVGVWLLTGLAMKGMVETREANERLQRTLR
ELEQLSLTDPLTGLSNRRHFMRVLPQELQRHSRTGQPLSVLVLDLRSLKWVNDRYGHAAG
DEALRKVAEGFRSRLRGSDLAFRIGGDEFAVLLPATDTAGALRVAEDLVRILSCARLEEA
PDARLEGSIGVATFPHHARDPDPLIAAADAALYRARELGVSVASAPAAEPA
>A0A068R452|diguanylate cyclase|EC 2.7.7.65|Xenorhabdus poinarii G6|TrEMBL
MKKRYSRVLPRPTLRQAFHRIHLLITFIMLSVVGIFLSLLALLAMQKYAESNLKLISTTI
AHTAQAAVVFQDKTAANEILAMIAVHEGFTEAKIFDAKQQLLASWQATPAPRTRNFKKLV
DRWLFPEPLILPVYHHQQKVGSVWLIGNSDHIIQFIYQALLVLFACLLFSAVISLYLSLR
MHDGIVRALQNITTVAHDVRQRRAFSRRVPSARIAELHELSQVFNHLLEELEEWQYHLQT
EKALLTWQAQHDSLTGLPNRATFERVLATVMNDKFMRQSAAILFIDGNRLKYVNDVYGHA
AGDHVLVTIAATLKRRVRKTDTVARLGGDEFAILLPSANLEDAERIAKNIIHAMDTPILL
PSGQPLRITLSIGIALSNGDLTAEQLLSEADAAMYHIKQRGGGWHSADTTKPKLNYLSRN
SL
>A0A8F6H8X2|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MLKELFLNLTILITFNYLFTVLFKESLSHKEDRPMFQLLKGAVCGLLGVFLIAFGFSYSD
SIIDLRNIPIIIAALYGGWVSTAAAFIIIVAGRILINFNASAIYSIAAVGMIAILSVAVF
RGKKPNHKNAFVMLLFSNVIITLTLLLLMPEQPAGALVYFWLISTLGGMLSLYIIKHEAD
ARLLFKQYKFQANYDFLTGIFNKRKFEEVSRVLYDRASQSPSSQLALIYLDIDHFKQIND
QYGHYEGDQVLKELGARLRLLLSSSDPSARIGGEEFAVLMPNCTYTKGLHLAEEIRHTID
ANPILLTSGDTIPVTVSLGIAHYPTNTSDPQTLPLIADRMLYKAKTSGRNQVCSTEKKE
>A0A411A2I6|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKISFNESQKLCSYTAVMLVLLSFFIYYASQQSAGLLITCITLLVTGAGIWFGAIYALVI
TLLVLFVLGSLLLWFQTGGFMASAGAESLQVLVIWGIALLLFSYIAGRIHELAKGLERSV
KQLREEITSFVAVDRVTGFDNHLRMKLELSEEIKRAERYGNSFVFLLLHMHYFKEFKSLY
GEKETDRLLAFISRQIRSSVRETDKKFRPSAERFGIVLTHTPEKNMPAVLAKLKKELDTY
RLQNGKYVSITFRVCYLAYRKDLQTAEQFLNELENEMMMNEL
>A0A858RA16|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium B3|TrEMBL
MSPTPPSQAGLSPVIDEHLRWLTRWHRAVFFPAECGLSGPDAAPMPMGFILWVKRAKDSE
LTDQPAVDRLVTLHEQLHRMARLVLMRVAEGTPCGHQAYESVAEKFDEFIQQCRRFEKAF
SMAGSGIDPLTGLRNRTGLQEELERELNRFRRTGKPFCLALCDLDKFKSVNDTYGHDAGD
RVLVAVAGAINRGIRSFDEAFRLGGEEMLILLKDTSLPEGMMVLERLRADIAALPVHLAD
GRTLYVTASFGLAESRLDLTLDALVDQTDQALYEAKRTGRNRIVTAAALKAAVG
>A0A3P8KGZ0|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MPDLQKHLPPRAPLAASRANLLPALLVIIAVSALCIFISKPLGPWNVIFTNSGLYIDLLA
LLFLVFMLWNSAKVRMSHVAVNWVRYGLLLWIAGGTFDLMDEIFVQPRWMGYYCEDLLRL
SGMLLTTIGIYKIIDRINILYVDARSQSLKDELTQLPNRRFFIDTIREKQGHRLALMILD
IDFFKKINDTYGHLMGDEVLFALGKQLAKLTSDKIQPARIGGEEFAIIVDGMSPEEVRSL
AQSILENVRTILINSDYPLSVSIGVGMRGRDEPQDAFIKKVDEALYKAKNSGRGRVEWAA
E
>A0A7S7R3W0|diguanylate cyclase|EC 2.7.7.65|Bacillus velezensis|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESASLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLRSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLPA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLIQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKTINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVRAIRENTEPRVTISCGV
SCWSKTGPMPLKMLVQQADEALYIAKRNGKNRLIIHQNSTTT
>I2US28|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 4.0522|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A8F6TPD6|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sanguinis|TrEMBL
MKAPSTPISMNASMVWLLAALLYFLFAASTIHLTSDGRTIATVWPANAVLLAMLLLDGRP
RWGLVLSAGLVANVAANWLTRGTMAGALLYSMANGVEIGLAAMLVRAGGRRFDALRSPQG
LLRFLIAAGLISPLVSGLLGASTAVALFAEPFTEAFTVWLLSDSLGLLIFTPMVFAVFSG
ELADTIAQWSWRERAVSAAILLSVALTTYAVFFVAALPALFLLYAPVMLVTFRIGPLGTN
LAVIIIAVMGAFATARGHGPVVMIQADALHHAHMLQIFLAVVLLTCLPVAAGLAEQRRLA
AELARREREAKDQAATDPLTGVLNRRGFALAAAEWSPAELGQSCCVAIDVDRFKDINDRW
GHGFGDRVLCHLATTLRAQAQPGDLIGRLGGDEFLMLVRTDQTRSGEAFCARVQAALRQT
PVDTGEQVQVMVSISLGLAAGQSDDTVEQLSRRADSALYAAKKAGRNTVRRA
>A0A659KZA2|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3356|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1A8Y2M1|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MSGALTLTGSLSLLDELLSSSEHIAYRLDFVRGGYDFISPRAANLLGIALADLHARGWEL
LDEHWVGDDRERCFAELVSLCAAAPGRSLSTRLEYRLRDAAGNMTWYCDSMTVLSDISGR
PLTACGIAVDVTLQREQEKALRDSEEKYRATMDAAQVGVFILQDYKFSYVNPKLLAMFGY
RDKELLNTHGPQALVIAEQHEFLIGKMRRRGAGEVSEPYELTGLRKDGSTFPMMVMGRPW
PIGGRPASVGTLIDLSAQRQIEQALKESSNRYAALFEGAQDAIVVADIDTGHLIDANVEA
ELLFLRPRENLIGMSFAALHPPALTAAYKEAYTRHIRAGRGGPDEMQIVTADGDIVDVEI
STNVIETAGRQRLIQGVFRNITQRKLTEAQLSLAARVFESSQEAIIITDARAVIISVNPA
LSGMTGYAAEEVIGRMLPFLGSDRQSAEFYSTMWKTLNDEGRWQGEVWNKRKNGEIYPVE
LTISVYRGASGRVLNYVGIESDISERLAAQENIRQLAYYDPLTRLPNRTLLQDRVEQALA
AAEREGKQVAVCFIDLDHFKVINDSLGHSAGDQILVQVSQRLLDCIRRRDTVARLGGDEF
VVLLSEITPDSAAEVARKILAAVARPFNIERHELSVTPSLGISLFPQDGRDFESLLKYAD
VAMYRAKESGRNAFQFFASDMNIAALERLVLENRLRQGLERGEFILHYQPQINVATGRIV
GAEALIRWQHPEIGMVSPGKFIPVAELSGLIGPLGDWVLREACRQNRAWQIAGLPSICIA
VNVSSVQFRGGRLEESVREVLAETGLPAECLELELTEGTLMSDAKATVDALQRLSAMNIR
LAIDDFGTGYSSLSYLKRFPIDRLKIDQSFVRDIVTDPDDWAIASAIISMGHSLRLKVIA
EGVEHANQLEMLAHQGCDEVQGYHLSFPLPAEEFAELLQQQTFASQVRQQSFDMGD
>A0A7W6KIS3|diguanylate cyclase|EC 2.7.7.65|Martelella radicis|TrEMBL
MSQYVIMTVNFAGLMALTAIAFGLVLKSVTGDHAQQALFGVVLGLGAAFVSLQPIMFVHG
LQIDPRNLFVGCAGAFAGPVGGAISFAIAAATRYFEGDPSAYVCVLSLFVATAAGLVWRS
LCWKRGKVGAVQLLLLGLGISLSYVCTFLLPREDWRVVFSSAIPFLTITNVIGTLVLGGF
LERERRRRLREDHLKDQASVDPLTGLKNRRAFETAYEATASLQSASLGMAFILIDLDHFK
KVNDTYGHAAGDRVLVGVAGKLVSRLRDFDLTARFGGEEFAVCLPDTGREDAMMIAERLR
RAVIEVGKSAAVPELTASIGICWTPSPVAMRKAFDSADRALYRAKLNGRNQVIVDSIDVG
GAAMLPPAVPPGEPDRSVPA
>A0A1A8XR69|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MSEVDEKADAPMIVRAMDIGKFVRVNDSFKVKVGFDAAELAEKPFLDWIDPRDRTIVQAA
FENNERSFFARHITRDGNTLQLQIQQAKHEDGHFVLGRCSRLPTQLVSDEARSAEATVSG
TLDAIARIIEEQNPGYKCSILLVADGRFVFGAGPSLSAEYNSAVNGYAIGPTVGSCGTAI
FWNTPVIVEDIQADPLWSPLAELAKKAGVAACWSHPFVCSSGKVLGALALYSPEPRTPTP
EQLRLLRASARITGLAVERGRAEEELKRADEVIKEVSNQLQATLNALPDLLFEVDSEGRF
IRYHTHRTDLLAVPPEAFIGKRFADVLPPDVVGPCQRAIDEAAQKGFSYGETYRLALPQG
EHWFELSVAPLPADDNSNQRFVIISRDITDRKNAEKQIEQLAYFDTLTGLPNRRMLTDRL
LQALAQAKRFDRALAVMFLDLDGFKVVNDTYGHDAGDKFLIEMTARLGNCIRSGDTVARH
GGDEFIIVLSEINGPDDAAVVAEKIVAALREPVPLEGHVVQVSVSVGIAVRPINGTEDAQ
ALMKAADGAMYAAKAAGRNGYRFSENESGKSGT
>A0A4P6WIZ8|diguanylate cyclase|EC 2.7.7.65|Citrobacter arsenatis|TrEMBL
MFPNTMNDENFYQKKVVPNEAMLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWMGIMGVNL
LPSTALLMIICINLMGAGGMRVFIAGVVLMAVSCLVTLQLTDISVAFTSTQLSVLLTLPV
LAIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLLIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAALTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A1R4LDD8|diguanylate cyclase|EC 2.7.7.65|Vibrio ruber DSM 16370|TrEMBL
MHISEHIHQFHITKINSYYLFISNFDISRCFQIFVVPLCITLKGTTPSLSVYPLMKTYFA
VKGRLLTPLVFAFALVGILFEGHIRQLERKLNEEYERIEREFFRASKMLTILDYSLNNYI
KVRQSLRLAHTTEIVNGVCHMRPKLAVTDDGENSQAHLQALEYIIVGDKALCDRNSTLHH
EVGFRIALAPVISLLHDLDEYLIGVHYIDPSGYIISSPDTLSINVTADMLEKIQSPSWDV
YQNLREDQLIKVRGPTVLQELQSTERLVSLMLPVYANHQFKGVISLNIMLDKLLNANQRL
AGRLHFIDTQTTSLPENAFQPYSLRDAGISFHHTVYYDMNWWYEFCQFVSLKRSTLILIT
LMYLLAVTFFLFMNTRHAKSYYEGLAVRDPLTGLRNRRGFEVFLERTPHQSYVAIAMFDI
DDFKAINDHFGHDVGDDVIRYVGDQIRCHIRTTDTVARYGGEEFVLYLTAERESHLRKTL
LRIKDALSEESKVVVEGGFTISGGVEIVPCSELCDIDAILKSADEKLYIAKESGKNQLIF
>A0A7Z9BTJ9|diguanylate cyclase|EC 2.7.7.65|Planktothrix paucivesiculata PCC 9631|TrEMBL
MVFDDLLLVSQFTSEQTLDQIMTLTQQIHQNLELGEILNVMVKGIRAILGCDRAVVYRFL
PDGDGVVAEESVSPEATPILGQLIYDPCFQAKWVDRYRHGQISSIEDVETRPLQACYKEL
LQRLQIAANLVVPILLPRSPSPQTSPTLPDLWGLLIVHQCQSSRHWTTLDIKFMQQMAMQ
LGIAIQYREADHHLRQLYQQKPQGISLPIQEINATHDCQCSDLGNEYLTEKSNNAISITE
LNGLDRLQTPIWIFDIENLQMWWANRAALHIWNATDREELIQRNFHDISEATRIRLNAYL
QQFKYKKNITETWTFYPESKPMSVRCNCSEIQIETGRMAMLVEGITEVANQSSPETLRAI
EVLNHTTVMISLYTLEGVPLMQNPSALECYGDTLHPNLNNDNAFVRHFVDPKIGETAIVT
AQSGAIFSIETQVYTLNGIRWHGLDVRCTRDPVTGNAMLLVNEKDITEKQSALIQYLHTE
QELRWKEALLRSMTDTSNLAFFVVDNRTDNILYFNHRFCEIWQIEHLEIKMLEGVLKNND
IIPDCIPLIADVPAFAESCKPLQSEENRMVIEDAIAFSDGRTIRRFSSQIRDQDDHYFGR
LYIFEDISDRQQVEINLKESEERYRSVIAAMGEGIVLQQADGQITACNQSAEKILGLTIH
QMTGLTSIDARWRAIQNDGSPFPGENHPAMVTLRTGKPEFDVTMGVHKPDGTLTWISINS
QPLFHADRPQAYAVVASFSDITVRKQAEETLKQQAERERMIYGITQRIRQSLDLDEILQT
TVAEVRQFLQTDRVIIYRFNPDWSGVVVKESVSAGTKSVLNQKITDSYFVENQGKSYEQN
TLKQTSDIYNAEINPCHLELLEKLQVRAILVVPILQSPGLWGLLVAHHCTGPREWHPLET
ELLKQLAIQLAIAIHQSELHQQLQLANQQLQNLAMVDQLTQIANRRCFDEILNQEWNRLI
REQRPLSLLLSDIDYFKQYNDTYGHSQGDICLQQVAQALQQGVQRSVDLVARYGGEEFVV
ILPHTDQEGALQVAQKIQDVLERFNLPHRSSNVADRVTMSIGICTLIPTVERFPLDLING
ADHALYQAKTQGRNRAVSSIL
>A0A4U6H0G9|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls714|TrEMBL
MFPNTMNDENFFQKKVVADEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWLGIMGANL
LPSTALLMITCINLMGAGGMRVFLAGVVLMAVSCLVTLQLTDIPVAVSSGQLSVVLSLPV
LVMYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A1V5Q5M7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MLFFGNNPIPDGVKFPSSGSDFFDNAIRNADLFIHPDDVKLMKKTYSRDVILKNLEKEGH
YTVPFRTLIDGVIEHMRCFFIMCDDRKHIVCCLENIENEIRKSEKKERELQSARRMARMD
ELTGVRNRNALKEYAAELDGMIKSGKIEHSFAIVMCDINDLKLINDTRGHSFGDEAIQRT
GRLISDVYGHSPVFRVGGDEFVAIIKGRDYEHRDELLSMIRKESLENKRLRSGPVIACGM
ALFDPARDKDFDSVYNRADSRMYEDKTSLKSERITDIYGNRGELDKPITDERKWLLDSMY
GALLTVAGGGYVYLNDMKYDYSRWSLSLIDDFGIVSEYMYHADRIWFGHIHPDDKAAYRE
AVEAVFRGDGEVRQLRYRARRQDGKYVWITTRCFILSDSDGKPDYFGGIMILN
>D6JBJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli B354|TrEMBL
MGVVRVQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISS
QRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQ
IELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAM
YVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQSEHASNTE
PQVTVSVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPD
HPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDF
GSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEK
ARPLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGR
VGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYD
FEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A0H5LR54|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHIMTWNSGAERNTGYAAEEIIGQSFELF
YTPEDLAGKLPTKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDADNNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDNG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYASNEIIAQHFGCFFLPEDIAAGLPEKLLKTAASAGRIEREGWLVRKDMTRFWAVTII
TVVHDHNGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDC
EGRVVLMNLKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNRLDAFNQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIHNRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLADSLSELSDNEQHILCYVDLDFFKDVNDTAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCKNKPATDILEQVVTDISAIQFHWHGQSYTFTASLGAVTL
NRQSETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A8E5U7T5|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF14523|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0T9N658|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MRIKKPHLRLIVITLSVGGILLTSIFLIAVIMVFQRENIEKDLLDANSSYAMKMSDVMSG
YIEMAQGELAYGAKKIKSTNDIDSLKDEADRLRLQSGMFNSVFVVSNDAVVLATSPESLD
LVGTRLNSSASKLAIEEKKPFISSPFKSVTGNLIILLSHPIYDKNGNYIGHVGGSIYLKK
HSLFSDVLSRYFFKSDTEISIVSDDGTVIFNNDNSAVGRPMVMSDDLKSKLTESDRGEGE
FFFGGNRYLLGYAHMKNTAWNVLVYSHAESATTILITYAKSVLVLLIVIIIAFSLLSYFI
ASRISLPLEKLAISTNAKDIGASLVYIKAINAWYAEADRLKKALFTHVKVMMERVDSLNE
VALKDPLTGVNNRLGFSTKIQNNKYGAGASVIAIDVDFFKKINDSFGHGVGDEVLVSLAQ
IIKSCCRSEDIICRFGGEEFVVFLPNTSVVTAECVAERIRSVIERTVFPNNLRVTVSAGV
ATQDDPLGGIDFLLKNADDALYQAKREGRNKVIVYSAI
>A0A8E5U7P2|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF14523|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>V0SN55|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907672|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1C7FHX3|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MSNFVGRHLEEMADIRATRKCKLVRLCSLLSICVLTGYGFAYFANHENVFATINFVCCVV
LALNLWHLHYHRSLNYSDLILTGVLMLQGVILLLYSERFPDRLMWIFPIIAATILINEFR
TGLLFSVSFCALAIAASLFTDAVFTQLNTSHERFILSLVVICLICNTASFYYSKMLNYIQ
SLYREGIEDLAYLDQLTGLANRWSFEHWATKKLAEIIHLPSTTALVFLDIDDFKEINDTY
GHEVGDRVLQQFSKRLKNNIRTRDRDSNKHDYSIARFAGDEFVILLYDVRSKQDLEGILH
RICHLFQDSYSGSKQVSSLTVSVGVALYPQDADNLHELTRCADKAMYAAKHKGKNQFQYY
HGETLCSLQEIPTLTEGNVRQINNA
>A0A1T4T278|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MNEISLADFHLTMQVLDNLDVGVVILDENYNVCAWNTFMQAYSGISSVKIIGESLFDIVP
DLPHSWLQSKIQSTFKLRMRSFSAWEDRPWVFRFLNFCPVSGSSDIMFQNMTLTPLRSLS
GEYTHICLTITDVTDIAKNKNHLRDSNKQLTYLSITDRLTQLYNRGHWESCLADAFEHCH
QTQIPATLIMFDIDHFKRVNDTYGHVAGDGVIKVIADILRRTKRQTDIAGRYGGEEFGII
LPGTSAELAGYFTERLRNRIEQETIFDDQRGTINVTISLGISEWNSTLTDYKSWLEKSDL
ALYESKKRGRNTTTIITHDDCYSDSKGEFILLDNDQHLPAK
>A0A1T4U8R2|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MHNRMFLIERRHSMNISYSIRKKITQYILLCLSLLIIFNIVYWSYDQYRSINNLLARNRV
VTENNIATIISKNTNLLTAISNDDIVKNSSLLLSQRIEFIRPYQEAFNIEILGISDINGN
AATTYSNNIENINYRSYFKQAIQQQKLIISNLIHSPISNSYIYILCKPFTNSVNDGIIFA
SVSYAEIKNALGYQENTSIKNNILNDCITDKNNCRNINTLNSNKLYYSLDNDQISLNIIN
KKTFSYHTINNNNQLELLTLRPLKNTPWYLVSTFNYNQYLNERFIFVIINILISIMTSVA
IGYYLMKKIAVITSPIDTFIRESAFIVPMQSESKNDNININHHFKNIIDTTKDGVYCSRT
DLLNRKYFIQHANIMIQNSHKNLALLFIDLDNLKTINDTLGHFYGDDVISMFAQHVKSFF
NQPADLIGRFGGDEFIVLTNNFYNKKDLINQLEKLVKQLNGSVSNGDITILFSASIGVAI
TNNQTQNIEQLINNADQAVYDSKKKGKNCYSFYVAH
>A0A5E4Z1L5|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MTIQRPPIPPPSGAPDAPFMPHASAAGLSAAEMPGHASADNHANGALHDRSLSAPAGAAG
PAGAAGAPAKRRRRPSLQGVLRRTHLRLAVSAVVLAAVSLTLVAWIALRVYAENNLLLLG
RSLAYTVEAAVVFGDRVAAQEAIALIAHEEDVVQVRVLDAHGAQFALWRRPDGGALATLE
RAVADVALPGPVTLPIRHDGDVVGHIEVQGQGHQFFVFLLSGVGGVLACLLVTFAVATVL
AKRMHRDIVKPLRALAEVAHAVRRERAFHQRVAATPIAELKELGDDFNALLDEFEGWQNH
LRAQNATLAHQANHDQLTGLPNRAYFESRLAQALVDARELGTHVALLYLDSDRFKEINDH
QGHDAGDAVLVAIAERLRQPLREGDLVARLGGDEFAVMLPGVRQTSNAVRLAQSLLVAME
KPIALPGGGEIVTSMSIGVALYPTHAPDAPALLRAADAAMYQAKRAGVGTWHVAESPKG
>A0A212K600|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MADPADLERLRETLVELDRLRRHERALRLETESLLRALRTLGSAHDADELFDIVVGALRD
MVPFETALLVTLGGRGGFRVVRGTAPRLLGMRWSPRALLQRVLDGETVALFDTAQSPDWQ
TLPKAARAAARSAIMMPVRSQAISGTIVFGHPDAAFFTPAHVHLLKRFTPLIDQALDVMA
VRERLEAERLAARLADAGRRKAEAEIRRARDLMESAIGFAPIYLWEIDAELRYAFAEGTA
KVLGYAPEELLGRLSIDYFDTQDPPTRAWIAQMERREPFENVVIRRRCKSGGKIWAAVSG
VPMFDDRGAFRGYRGITMDVTESTEAKLKLEQMALHDALTGLANRRKFVDRFEPATARML
RSGQPLSLLAVDVDHFKRINDVYGHPAGDEVLIAVGRILDRTVRRTDLAARFGGEEFMVL
LENTDAAGAVEVAEKLRLAVAAERFAAGAGETVGVTISIGVATATRDAPPSLDDLIERAD
HALYAAKLAGRNRVQAED
>A0A6N3D0I3|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAG
QDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENTQMILEVNQRCTFEIIEDRGKLL
VKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDN
TYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPDLPKALEDCERCFAKGPTYSSEY
RIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNIT
DIMFEYDIENDTLIKYQRVEIDKKIELENFETKNYSKLLESGKIIHLDDIGKLLEVLHGN
LRETIEIRQVNSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQ
RDPLTQLYNQRVSQNLIEEYLCSSDSKNNDALLVIDIDDFKTVNDTFGHLEGNEVLVAVS
KILLHNTHDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIG
IAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSTYE
>A0A654B0W6|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. AX6|TrEMBL
MLTNPAPLDFERSEARDRKRRQWIGFGALVLLVVMLAALVASTMNQARIRNSAEAQHVLT
QDMLLVSSKLQLSIHAAGRAVRGYMITNEARSLLPFVRERNEGRALVEKLGSLAGNNADR
RAQVAAIGMELDSIYVMGDRLVEMQQNGAREVAIERLRSGRTEQRMASILGRIDALAQAE
IDEQRLHADAASAADRRQEILTYSLAALALVFLGIAGMIGVGAARAHVRAVALSARLHYM
ASHDELTGLLNRRSFFAALQRERDLSARTGRSLAVAIVDIDLFKRINDSHGHRAGDIVLT
HVATLLTDTLRSHDLVGRIGGEEFAVLMPHTEISAARTICERLRRIIARSTVPLPSGVEA
TITISTGIATFENDEDRDSLMGRADHALYAAKSGGRNQVRLAA
>A0A6B9BFK1|diguanylate cyclase|EC 2.7.7.65|Mycobacterium avium subsp. avium|TrEMBL
MTADQVSQPPASGSSRFAVYDYVDGRERLVHAVQELSLARSLPDIQRIVRSSARELTGCD
GATFVLRDNDRCYYADEDAIAPLWKGSRFPMTSCISGWAMLNRDAAVIPDIYRDPRIPHN
LYRPTFVKSLVMVPIRKLDPIGAIGNYWAEPHQPSEHEVRLLQALADSTSMAMENVAIYS
EMEQRVRDRTAALERANEEIRRLSVTDELTGLNNRRGFYLLAGQKLSGSHRLGHACVLAF
LDVDGLKQVNDEQGHDAGDMLIKDVAEVLRSIRRESDILARIGGDEFCVMVTESDQDSAP
LRERLAEAFAAFNATGDRPYRLSASVGLVRAPVFDTASVDELLARADELMYVEKKARRTA
G
>E1ISK0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 145-7|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVLDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A0P1G640|diguanylate cyclase|EC 2.7.7.65|Tropicibacter naphthalenivorans|TrEMBL
MVLHSSRYVARKKDTWSEVPSLNVRSILRRANGLRSGALVFATAMIGAILTDYLFGWQAE
LLADYGAPRTNPMTLLALICAVVTTWKQRPMARVRGAERGLWLVVMALAMAHPFSEALSA
AIWPTHPMGRFGWNSALTLFLIGLAHLLRYLDRSYGLIAAMIALFVPLVALNGYISGVTD
FFGAMSLTTLAVQLPLALANLLCFARHPMLKGMLRDSVAGGLMRRQLQLSIALFLLIPLT
LRPELSQMRRMFPLINTMEITFMLGMGLYFGARLTRLLDTERQIKTNLLTDLTLDPLTGA
ATRKRAVNSFLRLDVHQPAGVILCDIDHFKRVNDMLGHNAGDDALKAVVKALRSELRVTD
VLARWGGEEFLIIAKIPDAKALETLTERLRTVVHRVDVPGLEEGHITCSYGAIMLDTPTG
WDLRDCVAMADDALYQAKSQGRDRVVIAEYVPAAVLVDQPEERLARA
>H8FSC7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MMGSATEVSLLDEDPAITGALFADIRAAIGRGRDRLEPSCLLVLDIDHYRALVEDRGDES
AHHALIRVAHTIVGMLPPGTPAARLGSDKFAALLNATGLRDALRLAETIRATLAGVGPRP
ETATDPFSVSIGVADAVGLHGETPAAALERAGEALFRAKREGRNRTKVAHPPRPILTEIR
SQP
>A0A5Q5EBW5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. CRENT-193|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNATPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRYYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTKLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDALRIAERIRRRVEKIKVNSPTGDIIPLSLSI
GVAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A655BMA1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans|TrEMBL
MDDITQENVMSFLTPVYLAGSLKGIVMVDVNQDNLKNIFYTQDRPLVWRYLNVTLKDMDS
GKEIIINQSKNNLFQYVNYSHDIPGGLRVSLSLDLTYFLVSSWKALAFYLLATALLLNMV
RMHFRLYRNVTRENISDAMTGLYNRKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLIN
DTQGHQEGDRIITLLAKAIKTSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNL
QIIAPDKTVHFSAGIYNMQPNDTINDAYQASDAQLYLNKQQKQHRSS
>A0A1S7S2R0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. NCPPB 925|TrEMBL
MEETAYQGTDRQVEPGQKLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAAGEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDDSILV
TGFNPSDVLALIGAQTKNAVWLFRYDEADSGFRQIATAFDNATDDGEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVVTPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEHLAASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQTTKGDCES
DAAMLAARVVHAVSRRFNLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEPGMDMAAKHKHALEIDMKSALENHEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLITPDRFITLAEENNFIKPLGEWVLAQACADAMRWPKDIRLAVNLSAVQLSNDDIV
PVVDRALEKSGFPAERLELEVTETAMLERDSSTKALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPANPMCSAIVNTIIDMAEQIGLKVTAEGVENMDQLEALKLS
GCDEAQGYYFAEPAPLARILRNRAVITPVAKDEIDDVGQSVRNAYHPPQKAI
>A0A8G0I3T6|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. sptzw28|TrEMBL
MTWLDLLLFLILFMVFVYVFATNVITQIHKVYLLFHFFMMLWPFGQVAVHTTDNPNLQLV
YVNISFIGMSMLGFGWLLFTKFLTNRAYVPGRKSIVYALLPSMLVLIGILWNPEHLFMSA
VDNHYEQRVYGPIFWVLILVLLSYYVYSTRLLWRAYCSESQVQDRPQIANALTGIFVIVG
FATLDLLLNVVFDKWLPVIPGLTSTGIVISNLYFVFSIRKHRMFDIIKIAQQDVADTMSA
GVIVMDEQDYVIEMNRAVNPELRIALGHLFDMEALLEACALSDLEEEFLQTYRLHPERRI
QADIAVRQPDDSFVYLSMHVAPIMIQQKMMGRVITFQDDTELRRLIEESYAQYEALQERN
RALLYMQDELFQANQKLEQMAVTDSLTGCFNRRYLMLQLEHEVMTNLRYRIPFAIFLFDI
DLFKTVNDTYGHLVGDEVIRRTAEIVRGALRRTDILARYGGEEFAVYLPHTNRDQAEVLA
QRIRVAVEDNEIAAGKEKNSVSITISIGVLAVEAQHAEEVDDAKIYLRELFAKADAALYE
AKRGGRNRIVNVS
>A0A1V6AMQ6|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MDSEWYKKFSEQYHIDMDIIINTIRQIPICGFFKDTELIFRVANNMDPYVKKEYRNNIEG
LKDSDVLDDEETIKMFEKEDKYILQTGANKRYIHKINIDSTIKYMDIFKKPIYNLNNEII
GLVCIIHDTTKSVEENIWIQEQLKLMSDITRIDKILLNIQKDISLIQDILRIFAEYCNSG
RAYFIEFTDECRVKNTYEYCTEPSLSKKEHLFDIDMRNFPYWLEQFFEEKHIFIEDIETI
SEVMPFEYEYLKGQNIKSLYAVPIVVEDASTSKKKLVAFLGVDNPLLKKQSSFFIDRLAF
SLSLAYSNYKEYNEILKMNKYDLSTNLLNRNEYIRFVNSYEPKKRLACVYIDVNGLHDYN
NKYGHLMGDDLLKKVANALLDSFQGASIFRIGGDEFIVFCENDSKKNVLSYINEFHSKTE
EYGIYVSSGLTYATGKDIDIHKMIKTADASMLENKRKFYCNLTDIEDKSKLISKE
>A0A7H4LUV1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MLELVTRMESTYLTRIDFDAQRQHIMYAHNSSEMQIPEGFSVPWNDSLCKRALDDRCIFS
NDVAERWRSCLAAQDLGDRHLFQHSRAPDRRLIIRHAVRHQPGKTAL
>A0A8F8U2A2|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESVSLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLCSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLPA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLVQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKNINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVRAIRENTEPRVTISCGV
SCWSKTGPMPLKLLVQQADEALYIAKRNGKNRLIIHQNSTTT
>A0A5Y3AWL2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHDTLLENQGWLKKLARRFGPGHVVNICFLSVMLFSTLLTWREVIVLKEAYITSQRNHL
GSVANALDRQLQFNMDSLIFLRNGMHEALVAPLAFNVLQSAVTQFEQRRAKRFWQLELDK
RRTLPLYGVSDEFVASTTILSRSNSALANELTATLELGYLVRLARSSATIMSQIVYASRS
GFYLSTLPTAYGSDILSRYYQYVTQPWFSGQNQRHNPQRGVRWFTSSPSSSDEQQKVTAS
LPLDHDNYWYGVLAMDIPVPSLQQFLRDAAEKDIEGEYQLYDSQLRLLAGSVSEQQLANR
FNEREQASLAHEIEKDTQGGLRLGTRYVSWERLDHFDGVLLRVHTFRESIQGNFGSISIA
LALLWALFTAMLLISWGVIRHMVSNMYVLQHSLQWQAWHDPLTRLYNRGALFERARRLAQ
RYRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRTHDIAGRVGGEEF
CIVLPGATKAQAQQIAERIRQRINDKEILVTKSTTLRISASMGVSSAQENDNYDFEQLQS
LADRRLYYAKQSGRNRICASDAP
>A0A6D2GDR1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVSQPV
FGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAA
LFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVIVLYP
LLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLL
IIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSA
ITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRN
RTEVAA
>A0A702LDK2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKAFDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A011MY75|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MVTRGVTDGRSIAAPFLSARMSDPKNPLEVARETFRLLSERKLLPTPANYQACYNEVARL
PNVAGFPEAPMRQLAAALGRLSPPADQQQLAALEAAIARRSWQGVQEALLTFTSRNQPAT
VNQMHESASSSGSAPALLVGLLPPLMHLIESLLPSLCQDDDSLLAQGRQLLQTLAAQTDD
HQQLLPRLAAFSQRISLIAEEQGEVRLTLLKLLQLIVDNIAALSVDERSVRGQIDTLARA
VLPPLTLRRLDDVERRLQDVIGRQRAAKERALAAQEAMRTMLAAFIDQLAMMNQSSTDFQ
DDLEASALLIAEVQTIEDLTPLLQRVLHATRSMAADTAAARDQLGELQTRVVDTNAELTR
LHEELQQASASARHDPLTDVLNRRGLDEALAREVASMRRKSEQPLSLSLLDVDNFKQIND
RLGHATGDDALVHLVQVVRQHMRPVDTLARYGGEEFVILMPDTRLAEGMTAMQRLQRELT
RNFFLAGNEKILITFSAGVAELHAEESGEEAIRRADQAMYLAKRAGKNRVMGG
>A0A378ZBJ0|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MKDASTNPAMRTQTKRGRDFSRRVLGLRSLGCALSAIAVYTAIRHAGASHLGYGIWALNA
FLWPAFAHAIAMASPDPVSAERRNLLCDSAFGGGWVVAMQFSGAPSAVLVSVLLMHNASA
GGYRLLRDGVLAMIGGGLVIGAIVGFAFKTVVDFSELLASLPLLLIYPTLVGLTSFRLAK
RLARSERTLRRISEQDDLTSLLNRRSWMRALTTCYADKRVGRGGAASIALIDIDGFKEIN
DVHGHLQGDSLIRILSDVLVNQLGAQDVSGRYGGDEFCVLFDGQSAEKARRKLERVRAAF
AEATRGLDASGSVTLSVGVANYDADLGSPTAWLALADGALYAAKRSGKDRVVVARAGGGF
EGAVLP
>A0A1V5GVZ0|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA179|TrEMBL
MLKLVPGITTYPDITAARLTIDGGMYLTENFQQTPWHMESEIQSRCRAVGSLEVFYLQER
PLRFEGPFTREEKRLLDLIASRLGRLVSRKRAEEMLTESEQRYRSLFEDSRDAIYTTSRD
GVILDANEAALELFGYPRTEMIGLDVMQIYATRDERDKFQQEVEDRGSVRNFEVLLKRKD
GTIITCLYTSSVRKSAQGDILGYHSIVRDITDIKRIEEEKQDLIEELKLALERIKTLKGL
VPICASCKKIRDDRGYWNQLEEYIEAHSDAVFSHGLCPECQKRFEEE
>A0A2N7R6T2|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MNARISAKLARKPRPTLDSVLRRAHLSVSLIAVLAAGLTLTAVALLALRVYSDQNLRLVA
RSMSYTVEAAVVFGDPMAAKEALALIGVNEDIDQAQVSDKNGNMLARWERGEHGTRYYIE
RTLTGWMLPDSLTFPITHDEQVIGSIKLIPHSRSLLPFLLSGLSCLLACLALSLIVAVRL
SRRMETEITAPLRHLAETAHRVRRDRSFELRVPPANIAELNQINDDFNALLDELEAWQSH
LQKENASLSHRANHDSLTGLSNRAFMEAELERAITEARIGNGKVAVLFLDSDRFKYINDT
FGHASGDRVLVTIAARIKQQLREGDLVARLGGDEFAILLRPLRSSADAMHIADNIISAMS
QAIELPTGNSIVTSLTIGVAVFPDHAIDAVSLVGAADEAMYRAKQAQRGTRQVAHQPQTH
IHP
>A0A127MRH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MLTLSIALAAAAALYLAIEWRNVREPSLLFWSAGFSTIAVGSTLVLLRMARLAARDPLTA
LYNRRALEVRAPRLLEEVCSARPGALLLIDIDNFKLVNDLHGHIAGDRLLVMLSEMIRAL
LPGGALAARLGGDEFVILLGDVTDERVVALGSALREQFHRAAAQAFATPEAVTLSIGASL
FDRPPASLAALIEQGDAALYESKRGGRDSIRLVAGGEA
>A0A127MYA1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MSLSLPTLLLVDLYILALVGVLMFFAWYGGRREPTLGYMAAMLLLGALSTFLIALRSFGL
ELLAIVAGNMVVALSCALLWTSMRVFAGRAPYWPGVAAGAVLWLLLCLWPAFLQSMVLRI
QVHSALTVVYCLLAAAELWRSRQRLEVPLRPTLALLLFHAGFYTLRIFVDRGEAPVVPAG
TYTTLFTLLVFETMMVAVGLAFTTLTMVKDRAELKFRSAALSDPLTGIGNRRAFMDSGER
LLRLCAERGEPVALLVCDLDNFKRLNDAYGHPVGDRALQEFSRITASRMRRQDVFGRIGG
EEFACLLIGAGTEAACQVAERIRREFAEVPFVADGLLSVSIGVATSEEGGYELARLLSLA
DQALYLAKAKGRNRIELSAPGPGREGRGHR
>A0A841MUU2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLLEKESAEFFSDD
LIQQRLRDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1T5I0F1|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MNEISLADFHLTMQVLDNFDAGVVILDENYNVCAWNTFMQAYSGISSVQIMGKSLFEVVP
DLPESWLQSKIQSTFKLRMRSFSAWEDRPWVFRFLNFCPISGSSDIMFQNMTLTPLRSLS
GEYNHICLTITDVTDIAKNKNHLHESNKQLTHLSITDRLTQLYNRGHWENCLADAFDYCH
QTQIPATLIMFDIDHFKRVNDTYGHVAGDGVIKVIADVLRRTKRQTDIAGRYGGEEFGII
LPGTPAELAGYFTERLRNRIERETVFDDQRGVVKVTISLGVCEWDSTLTDYKSWLEKSDL
ALYESKKRGRNTTTIINSDNCYKNSKGEFILSDCHEHMPIK
>A0A427WRI8|diguanylate cyclase|EC 2.7.7.65|Achromobacter denitrificans|TrEMBL
MSSSSLGFPSSPGQSEGLPGPACYLTASNEQAWEAVYRSVDAYTRGQVAAVVADSVGQLV
DTFYSVLLADAEAGPRLSHEIVASRLHSGMTRWLKGLLCVRDQGDIGALMATQKKVGEVH
ARVHIPMHLVMTGARILKNEIAMRLRASDLDGIAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPALLQITEAVARLDQEVLPQLMRDEAQGQASSMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSEFSVLLLDIDHFK
AINDEHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAGRDAALAAAQKLG
AEIRRHVFSIAEAGPQHITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDRSEAA
>A0A259UVA4|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MSASNGRDMIKIWGDPATQLQLIIRRMGAIAVLFSLTAAVLNQGPQWLVITGLASLYILY
NMLLCWRQAKPQLGDLVINLVLCAGLTAVGAVYSNILYHLLLVRMVLMVGRDQAMRLTLV
IAFVYVTAQLFATHAMAADFWLDVAFNVISFALLSGTAVYMCNVVETQCENQGQIAELMR
ENAHHYELAHTDQLTGLLNHRAYLEKTADISQYILLIVDIDHFKKLNDAYGHLFGDQVLE
MVGRMLKMSIRSKDMAFRYGGEEFALVLPSTSLDLGLKIAERLRFQVANCDFVHKGGRVK
ITISIGVARKSPNVACQDAFSKADSALYRAKRQGRNQCVVF
>A0A1T5YCJ3|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MVTTYPGRNGFGSESNRCSTGAQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLA
ATGMSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVVYCDVAILIGICVVTTTGVA
FVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTML
LANLFAGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVV
VVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVGDAPPDI
DYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAK
KAG
>A0A259UNN0|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MLCLPYDTVKYNYRGSILVCLIVVFGCASVYMVSKFLTEAVNRDFVDGLCMIQILLAGAI
FAIASTIFFIHQNHALCRRIKTYQKLAQELSHQRDFDMLSGIKNRNAFIRFAQQVEKRGD
NVSVMVCDIDGLKIINDTLGHMAGDKIIRKSAEILNEACPSNANIFRTGGDEYVVIIQEV
LEEQELMKLRQSIKIMIASYNATHPSIPLSISIGFASTSANISEFWEVSKEADYNMYQEK
RACQEKVYNNLRTALIE
>A0A554WLA0|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MRVSIRFDAEQLQALLRSLPDPAFVLSASGRYVAVFGGADTRYYHDGSPLVGRTLHEVLV
PARAEAFLADIRAALRDGGLRIVEYELSNRDVRGLSDVGPAEPIWFEGRVMPLPFTVEGE
AVVLWVASNITHRRQLQERLRALSETDELTGLANRRRFRAELQACYEAWARYGQPVALLY
LDLDRFKAINDQLGHERGDEALRAVAAVLEGARRRTDLAARLGGDEFALLCPHTGLGEAA
ALARRLVAPVRRALAAFALGDGEPASVSIGWAECEPGDRGGGDLVRRADAALYRAKGARG
RTAPA
>A0A1T5HX13|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MNISHSIRKKITHYILLCLSLLVIFNIGYWSYNQYTNIQKMLTRNQTVTENNVLTIVSKH
TDLLTAISNDTVMQDLSLQLPQRIEIIRPYQQAFNIETLGISDMKGNAATTYRMNAENIN
YRHYFQQAIQEKRLTISNLIYSPISNSYVYIICKPFNNSINEGTIFASVSYADINHALTY
QENTSIKNNILNDCKDTSNNCKNTNTLKKNNIYSSLNNEQISHNIKNKNTFSYHVINNKN
QLEILSLHPLKNTPWYLVTTLNYNQYLKDRVLFMIINICISVIASIAIGYYLMKKVSIIT
SPIDAFIKESTSIVPIQSPSKNSNIDINHHFKNIINTTKDGVYCSRTNLLNRKYFIQHAN
ITIQKRHQNLALLFIDLDNLKTINDTLGHYYGDDVISIFAQHVKSFFNNPIDLIGRFGGD
EFIVLTSGFNNETDLINILETLISQLNGSVSNGDIVIPFSASIGVAVTDNQTRDIEQLIN
NADQAVYDSKKKGKNCYSFYVNH
>A0A8G0UXR2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MWRRSLPQPRWLPRLAVMRPHRVVVGCFAVVLLLALVVGLRDVYLVRERDLRARQHNLEL
RALGVEAVLEGERRRLEYLSTYAERLFEIQASADAVAPDAAIRQAYAQRNATVWQMKLPL
DGPALIGVGPAGLTGLRSFDRRDPDLMADLYVGRMISELLGLSIRADHVQGNAIFISSNG
FFVAYPAIDPAVAPSMMQRFDSMPYYRGQTPEVNPGRELYWVPMYDDFQSKRRMTTLSVP
IYAGQQFRGVVAIDVEQKRLDELLRAASDPGAVQYMMNAHGDVLAISDDPVRKVQKWPDA
VPGNWKDFAPADLFARGSGMVKHDGDYLLFHRAPQSPWLLMDLVPARKLYASMFASMSRP
LLMIWVLLPLLLWITLKVVTQLFDHYIALGEKLQEIARQDPLTGLANRRRMRELAQSEFE
RQKRDGQPLALVMIDIDFFKKVNDHWGHASGDKVLVELARTMRANLRNVDQPARLGGEEF
AVLMPNTSLAEAAQSAERLRRAIAACVVEADLEACVERADRIIRFTISVGVAEARGEAAD
GVPMTLDGLAAIADRRLYDAKTQGRNRVVSDDNAHAAAVPQVQA
>A0A8G1D3Z4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MKRSARRFSRPTLRAVLGRGHLGVALLAAGLAGVLVTLLGVAALRVYANHNLHLIARSIN
YTVEAAVVFDDSAAANEALALIASTEEVADAKVYDNDGDLLAHWQRDEQGVMAQLQSQVA
RSLLEEPISMPVQHMGQRVGHIELTGQGGSLVRFLLSGLVGILVCTVLSAVLALYLSRRL
FGDIIRPLRNLASVAHAARRERSFDRRVPQTQIAELNELGNDFNALLDELEVWQSHLQSE
NESLAHQASHDSLTGLPNRAFFEGRLSRSLRNAARSEDHLALLFLDSDHFKQINDSLGHA
VGDEVLISVANRVRAQLREHDLVARLGGDEFAVLLTPLHSREDAKRIAEKIVASMKLPVQ
LEDGTSLTTSLSVGIAYYPDDGRDPASLLNAADAAMYQAKRNRRGHWQVAQTERCAPDAK
NRS
>A0A517WTR1|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MISPEKIWSSDQLPTLPAVAVKLLELSKDSDTDIKDVIETIKADPAITAKILKASNSSFF
SLRSECKGIERAVPLLGTMVVTSLALSFSLSESAITEGPLKSRFDSYWKQSIVQSAAAEL
LAAKLGNELQHDSFLIGLLQDIGHLAMLRSIPDELVKVLEQAEEQQRDTAELETEMLGIN
HAEVGVKMMERWQMSEQFKTAIRHHHDTVEELQALKSDPEFNAIITIATSAAIGDYFCSP
NSGLALQRLQDLTTEFFEMPHNDLHGFLESVQARFEEAAQVFQVNMDDIGSPYEIMATAN
EQLVRLTMKAQVDSTQASARQAVIEEQKVQLETENKQLQSKAVHDPLTKVYNRSFFNEAF
EKEIYNCARTATPIGIVFADIDHFKQLNDTYGHQFGDLVLQRVAKVADESTRRSDVFCRY
GGEEFVVMVSNPTENGIRELAERIRTLIENEVIEFEGKQVPITASLGAVVGIPTRNTAGL
AERLIAEADEAMYESKANGRNQVHVRSIIRKADRELQQLVKRSRFSRWLVTKKIFDIPTI
SKALLKCPKQGPLVKLGELAIAEKLLTAEEVSQILNLQKENGQRFGEIAIQQKLLTQEQV
AYILALQIEPPIALGKTLITLELLESTHTAELVKQYLAETKDSAAPIEERHQEPVKS
>A0A8G1CZ42|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 2hn|TrEMBL
MPVEPMVSPAPSRLLPLLSLFGLTLALTLAGILARPIESLSLFWPVNAVLAGVLLRNPRQ
ATPFGFALIYLAMVVADLACGSTWKPALWFNLCNLGAIISIWYLMARLARVHRRLRTPHG
TLCLFGACAVGAIVAASLACVMATPWFEQSLSATWLAWFSEQFSTSVLVLPVLLTAPSPR
ALSGHSSASQPIRLAPLLVLLASLAVSILFGGPGAIAFPIAALLWCALSYSPFLVALLAL
TAGSTLIVAVAQNLMHFSIPQSESGVTTLMSARLGIAMLVLGPLVLACVSSANRSLMARL
AHQATIDHLTGTLSRSAFIRRAHALLDNRQQAPLTLMMLDIDHFKTINDQHGHAVGDQVL
RQFATTLQDQLHDGELFARLGGEEFVIVVPGLAPELARFTAERLRRAVQDQHIAQPGQAL
RITVSIGVSGCAADTPAPSLDELLASADQALYRAKAQGRNRVEQAEGQRQVV
>A0A8G0UMZ2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pinatubonensis|TrEMBL
MPSYPLVLCLTIAVVCSIGMAVMAWPRRDDPTIQAFLVLAGGVVIWSGGRLLEISSADLP
GRILWAKIQYFGIVAVPIGWLVAMIHLSRPRYVVPWSLLSIPILMAVLTVVLVLTNTHHH
LVWTRITLMPPGVAPGAVFEHGPGYGVMAAWTYLLLALGFYFLVTAEVPNDALSRRGRAV
LAGSVAFPLLTHIAYLLRWTGPLGGDLTPATFSLMAVLVWFCGLRTHLDDIGHYARLRVF
DALREGCVVLGADDKIVEYNPAAARLVPALRRGQPVPAGWEEVFLRPQSADSQTVRPFIP
PGAHFELTAEAVTRMDGKRIGTLVFLLDISRYQSRELALTARLGQTEEQLSRVQADLDID
ALTGIPNRRYFQREAMLAVSRAFERREEMGLLILDVDLFKQYNDLYGHPRGDECLRQVAA
ALTRMLAGTQFCARLGGEEFAVVLPASTQEETRTVARAMVEAVRELGIPHHGTPVQPIVT
ISVGAVCAAPDAPRLEPLLHRADSAMYQAKRAGRNRFVFDGQAHADAWHGQD
>A0A7S8J1E4|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira kreftii|TrEMBL
MIKVLLVEDNVVDACLTRDILAEWSLETFEITHVSRLSDAFRHLARARFDAVLLDLSLPD
GYGLSTVRQMQAANPTIAIIVLSGLNDQTLALQAVKNGAQDYLVKGERQSELLARSIRYA
IERKRAEERLTYLAQYDQLTGLVNRTLFRDRLVQAMARSKRLQQPLGLMLLDLDGFKPVN
DTLGHNVGDQLLKLVAERLHECVREVDTVARMGGDEFTIILEGLICEEDITLVAERITKS
LAQPFQIDTHQASIGVSIGITVYPTDDHDVDELLKHADAAMYRAKQQGGSSYQFHIPNDP
QPSLLPRP
>A0A839TR87|diguanylate cyclase|EC 2.7.7.65|Paenibacillus rhizosphaerae|TrEMBL
MDRTELILEDLWHRKILNAYWIVTLMFFAAEAVLLLLGCIPFVTAGGGPEDWLRLGIPDG
CILLLMVAAQTWLRFEPKYRKQVVVGCGFLLSYLFYFIIQPIVDGAQMALLLPVLISVVY
FDRKLLYGFGTLTILLYCLIYLTERSLYQKPIQEFIQIQSVFIVSIMIGHTILVRVKEFM
RHLESVMKSEQQLLVERTISDKLLKIDALTGLYNHKAFHEYLEALLEHCEKYQLPLQLAI
IDIDNFKKVNDNYGHRVGDVVLKEVASKVMSTVTPNDFAARYGGEEFAIIMADKTLEEAE
DMAEQLREEIARTALPHTVKPVTVSIGLCNFQQGDDKESLFRKADMALYQAKRTGKNKVV
TAGEDAADYAG
>A0A0H3GS82|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae (strain HS11286)|TrEMBL
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGHNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVITHYSQALG
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQ
GREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADGRLYLAKQNGRNQVCFRSAA
>A0A1C5LFB8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNKLRKFNSKYMFLILVFIICFIGLFVYLKGDMYKCEILSEDEFATLKTWTVEKDNSKVI
LPYGFKYTGEPIVLTKKIDKANVFDDSQYLMVMSRYFDYTVYVDDTKLFDLTTPQNGFSK
TMGTQIRIVRIGKDLNEKTIKLEIRPLLEDHIQYSVAPMMIGTRSDIVWHILKSEQSEVI
TAVLIIIFGFVLLLLAIIIRCSEYEDDESSKMFYLGMISVICGIYLACQFKVSHIIAPNG
YLPYYFEFTSLMLISVAVSLFIQTNVDGVIKKLYTSMSCIFVLNVLVQTFLNFVLKIDYK
MMLFVTHILIGLFGILILSTMIIFHKKKSIQYMLISIMFPIVGSIIDIVRLYRISDDKTI
YFFSMGLYIFVLMQVTRTIRQYLAKSRSHLKAEVYEHLAFTDGLTELNNRLSFENDINEC
IGNNRPACISIDLNNLKRANDTMGHSAGDILIRGIATVLREAVGKDGKIYRIGGDEFVVL
IHDITDDGIEKVLKRIEKCRVKYNEENNVNLDFARGVSLYTEGDTTFENLVARADAEMYR
DKRLTKKGRRDDYE
>A0A1C5SH30|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKKTNDLYGHDMGDSAIKEIASIILKVISKEDIAIRYGGDEFIIITNYSSKDLSTKITDE
VFSFLNTHIPQVIIKIRNDSLNFLGFYV
>A0A1C6J9Q4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTNRRGCSTKRPARKPAGPAWLTRAGVTHALMVLGIDDFKRVNDTYGHQEGDRVLRRLGA
LLQQGFHEDDVIGRIGGDEFLVLMKDIDAYSARERAVEIVDKLARSLSSHPELRATCSAG
LAIAPEDSKDFDAVFARADQALYQAKQQGKNRLGIL
>A0A1C5PPM3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MFIVIDSNFISMYINCEQNNHWNYFYHTIAWACVYLFMDAIWIMNVKHLLTFSKIQSGIF
NSFYFCSLAMLVCFWYVYAQKTLHSAVLKHKKILVLTFIPLIFFIGSSLLSYWTHGLFVI
DQAGNYHRGKFLPFYFFILFAYILYLSIKAGYLSKKAKNYLYQNEYKVIVRFSFLPFITA
LIQITVDHLLIFNLGLTYSIFIVYNYFQQNLISLDPLTKINNREQLNIYLTMKMKENYPK
KDLYLFLLDIDQFKKINDELGHVVGDQIILKTADILKQIAHLHNCFISRYGGDEFIMVCE
RDKNVEITPVFNDLQRLFQQSYEGLQDFSVSIGYAKYDESLNYIPKFIEKADHYMYLNKN
VKK
>A0A1C6JU50|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKSKNEKQAGKTTEALAFAHVRRAFVCCLILGMLIFVFQNAFLAYKNMKQIAWTIQQSAS
AQVSEKVNESLKLLKSLASLPIFYDPGVDWEEKVEKLDKINEYYGYMFICYVDKDIVVYT
LGEEPASLASREHMQKVYASKQPYVTDSFVAGADGKTLNYTVIVPLMKDGVMTGSLFATI
VLDDTSALLKEITSTTTADAVLVGSKGQVMCSTNDTAYGASILDILGGYTLYGATDDQVE
EQMLNRKAGSFLSRAGAELMYTDYGPVENANWDVVVTVAFWPEFLSMLPSAVFVLFGMVL
LLLGVYYFVYRHARLQAKSMEHMVKSVQEIKKKVYQGSDPSELFDYENIIQLSSRGLNDD
LTGTFTRVIFLDRAEAMLREKRKKQDDQLLALCFIDLDDLKTLNDQNGHLAGDMVLQKIG
ALLREYGAKYDGLVGRYGGDEFILILRDIDSRQELDAVLKELVGRLSFDVCCEDKNIATH
CSIGASIWHQELTLGMLISNADKALYDVKCHGKANYSIFMYGERDEI
>A0A1C5Z984|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLKKYFEDESYNIMPCGVVAFQNDSTLKIISANDYYYSTYANGNFESLNICEEDKNIIAD
LKDKNEVVYKCIVSDGTIRYVCMHLTKYNENDILGILIDVTEQHTNLVRMKDERRCFTYA
LKSSKNIVFEHNVADDNMTLYIPVKGQTELKKLSIPNNTEDAVYELADKRDYGYLKENIY
NEKVENISVRMKLPGNKNYEWHRIFRNFEHDEKGNLKRIFGTITNIEDEKHHEKELKEKI
EIDPVLHVYNRNAGVERINEYIKSNPESRDYALFVIDIDDFKNINDTYGHLYGDTVIAMV
AEMLNKATDDDAIVGRYGGDEFFVFLKSSRIAENADRVVDNVCKINISEDKRITCSVGVA
DGRIFEEVPNYKALFSKADKALYSTKKNGKAHWEIYNENIVYDNSSHAIDYEVEDAENST
ELFKTRDMMKVFLELSSSAKNSDDAMYKIIRYVAEKFGIDWFQIMKVNIKEDLITISYEW
CSDPKFQNNAGKRGYYAHSDIKHFKEFFEKYPVFILSNEKINGFSLKFQREFEKNKKNGE
VVYNANITTGDSFFMFVCTRFGYENPWQIEECVELNMATKLMTMYISQSDKETENEKKLR
KIIDYDRKTSCYTIAKFYEQIGRLRKFAEEKDEQVALLHTDFSGMLDFNERFGQIEGDKV
FTEFVNCILPSDNDYNIITHIDGADIFFSAFRFKNLESFDKIDALNKQFSKMINEKYPGA
HIIVKTGIYVLKTNEVVGVGLDKALKAKKTVKNPTESFCIVYDKDKHENSRC
>A0A0C4WIR1|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum NCIMB 8003|TrEMBL
MPSTSPEQQAAAEWKLLLAQFPAPVAAQVRELATTHQAELAGYFYEQMLQDEQAMLFLTH
EQVKSRLHGTLQQWIVSLFSSTGDETALLALITQQKQIGEIHARIKIPIHLVLRGARHLR
ERLFELLCRQPLDTEHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQ
HIGVEQERQRSALLDWENQLMFDLAVGQLAAQLPRLSGSEFGLWFRHKGAHAFQGSRETE
LILQSMQHIDEVLLPLFEKAVAEPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESG
RDVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDHFKQINDEFGHEAGDLVLQQL
ATLLSNHCRGGDYVFRMGGEEFLVLLVDVHQGQALGVAEKLRQQAEKERFRLSGEHDLQL
TVSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVVLARELPG
>A0A740VHX5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 6,7:c:1,5|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFPDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLLRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A2X2IHZ2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIKKTMEIDVILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAISH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2X2JZC3|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDTVLAGMWVGVMGVNVLPSTA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A403M7F0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIVPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSIYRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A3R0X3P8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSDQIIVRVSQSLAKEQSLESLVRQLLEMLEMVTDMEPTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A8H8ZGI0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDEVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A8H8ZDZ4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSV
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A3P6L4D6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIVAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A402ZSU0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDTDSALYAADIAMYQEKKHKQKTPFVAHPALHS
>A0A5P9PKK5|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. YIM 10|TrEMBL
MTNSGFLDEVEGERTQPGWWPFGVLAIARWRLWGLPDRFLVGYVLAVDLTALTGAAVAFH
ALPVPARDWRPFWILLACCLVYVEVSRSIERSRADFLDGPHIDLNSVWMFAAALLLHPGL
AAVVIAVSFAYRWLRVRHRPVYRQTFSAAASMVSAFLANLVPFAPQEFAIFGAALLYGLS
NTALITFAVHRSRPGTTLREAMFSPADYALEASTIALGVLLAWALVDWPPVLVLIMGVTL
VLHRSTLVQQFRDQAGADGKTGLLNASKWTEVATAELARGRRRGLPASVLMLDLDHFKVV
NDRHGHLTGDQVLLAVAAALRAEVRSEDVLGRFGGEEFVILLPGTNRFDAVTIAERIRHR
VGQLLVSVPGGEIGVTVSIGVAAQPRDGQALDTLLAAADRALYVAKEAGRDRVRTMP
>A0A0S4I1R3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MDGPGFRHHQETFIAAQVRGDRLRQLFNQSVSAVFGSYLAALMLCGLCWERMDHNVMIGW
IGLLSASSLLRILMFVVYFRSPDSERTPQRWERIYWVTLVLSAGIWGAGALAVMPSDDLL
AQALVMLFAVGMSVSAVSCYSSYRYMTLVSIGLVLLPCTTWLVFQPTTLQVGMALAVVVF
ASFVARATRKLSEALETAFRLTREMELAHRIATHAAQTDELTGLKNRRAFFEHAQQLFNN
CQYHRLPLCAVMLDMDHFKHINDTYGHQVGDQVLRQMGVVISTCFRETDVYGRLGGEEFA
ILLPDTSIEVALEIAEHLIQSIGGLMTGPVYRISASLGVAAMEMQDPDLQSLMNNADKAL
YRAKARGRNQVAVSE
>A0A3A4A3R5|diguanylate cyclase|EC 2.7.7.65|Pectobacterium polaris|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAIRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMAETDDYIRGHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETRKVAAYTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A3N2SDW4|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MEMYLKKMKSEWLSLLEQTEPHIRQLTAEIAVANARTLCAEFYKVVLADPHAEEFLSNEQ
VEKQLKSALERWIIDILSCKEEDIDRLLAAQHTVAEVHARIGIPVELVEMGFRVLKKILY
PVIIFSSQVSADKLQIYHFSINSIDLAMEVMSRAFSFSESSMSKDDENYRIFSLLENAEE
EKERQIATLLTWELDILYKVVLDADFGNGMPLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LMQDFDGVIHALSAEGKSLGNKAERNKFLIQLRSTVSQILTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHANRVGTPLSVLVIDVDKFKQINDTWGHNTGDEILRRVSQVF
YDNVRSSDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKVKASDGNDIPLSLSI
GAAMFNGHPDYERLIQLADEALYIAKKRGRNRVEMWKAGQ
>A0A378GJT4|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MRIATITNWAYGATVCLTIVSGIVMLMASSADNAERQAVQQRLVFDRLTDEIESNAWSLS
DLARLYVVNKDPEVLSEYHQREKQQVEIEQRLSKLKDAGATGEELVLLHEGLQIVDGLQD
EQQTALANLAHEEAPIAVSLLYGKIYEQELDRAQERMDHFRQMLDTRALRAVQEATRDSR
ILRTLSEVMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVDTPNFKQIDE
IGDMAQAIRIFRENGLVRQQLERQRDADWAIRELLARMTQRLQGCECFDDVVNVAELFAP
NIAPGVAGRLYILDKDPWQMRCVASWLSPQGEPTPFHPDECWAVRRGQSHPPVHGEPDIG
CYHLPESCLDHTLCVPLIAQGEAIGLLSFQNLNEETTPSRAYLELMAEALGLALANQRLR
DALLEKALYDPLTGLRNRHHLEDTLRTQMGLAVRNDDPISCLMIDIDHFKNINDRFGHEA
GDGVIKSVASTIQRVVHDRGMAFRYGGEEFLVLLYDMDDDGANRIAREIFDGVRELVLRF
SGAEIGHVDVSIGVASYPQHAQSDNLLRAADVALYRAKELGRSRIVSFGSLAG
>A0A1V5IM85|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MLIRGDETHGYELAERLRRAVETVAVDVRGERAAVTISAGVAMYPSAASGEAELIEAADA
ALYESKRRGRNRVTVFTGVSGERELPASLSA
>A0A0M7AEV2|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MATNIALDLEQSFGELNECVLVTQPDRTIIFVNKAMENLLKVDRQDLIGTTTERFFADKK
HFENLGEIYDTPADQRHRKSYAFDIKTGDGSIVPLEIVSAPLFDADHELTGILFISRDQS
ERIALENRVKNIAETLDDALDAISEGFAIYDTDDKLVVCNNTYREIYAPSAPAMQPGNSF
ESVLKYGLDRDQYDTKGLTKEEWLRERLRHHKAADGKVIEQSLADGRWLRISETKTRSGR
RAGIRADITEMKTAKAEAESAYRNLSLIADNVSCSITEVDLEGRCVFINKIGCEWFNGTQ
EELIGTRLRERLPWKEREQVRQVFQKAYAGEKSAADIAFHFPDGISRECQFEATPRFDEA
GEVSGLVVMIVDITDKKKTERTLAELYAITSTNELTYEDKIAEILRLGCEHLDLPCGIIS
HVIDDRYSISHAHSPGCVIEPGTSFPLEDTYCTLTLDADGPIATAEASKSEFAKHPCYRV
FGLETYIGAPLLVDGEIHGTINFTSEEVRKRPFTEADVQIVRQFADWVGHEIARDRAHKA
LMQAKINLERIASIDDLTGIMNRRAFLEAANTEVARYRRTQRPFTAVMIDIDNFKRINDR
CGHAVGDEVLKKFTGIVGGALRAVDVFGRVGGEEFCMILHNTSMEDAMLVSQRLREKIVD
ECQFDNVDQTITCSMGLASIAREDVEFSTLMQRADTALYTAKETGRNRCVEFTPALEPDA
AV
>A0A5E6WH06|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLFRSNSRPTLGSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKSAANESLALIASSEEVADAQVLDSQGQLLAHWQRPENGLFSELEMQITR
ALLEKPISLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNASKHDERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKVEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVFPDHGVTPGALLDAADAAMYQAKRLSRGAQFTAGAEHPVDSVQT
RS
>A0A5E7GGQ1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MARRLYTSRTLGLGLGLLCVGAAMYPLDPAPWVWVLMLLNGILWPHVAYQWARRAKVPFH
AEHRNILMDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVGTVAQVLGIGI
GWLIFTPLFVAQTTPLQLYACLPLLSLYPLALGWICFRQATTLGRHKRELLALSRTDSLT
GLLNHGAWKDQLEVEFQRCQRQHRGGAVALIDIDHFKTINDTYGHVAGDIVLRQLSKILK
QNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQSPALKVSLSIGLA
AFNPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRRELLDPV
>A0A5E7RIP7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLFRSNSRPTLGSVIGRGHLIVALVGVAMASVSLTFLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKTAANESLALIASAEEVADAQVLDSQGQLLAHWQRPENGLFSELEMQITR
AILERPVSLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPQAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKHDERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHTVEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVFPDHGMTPGALLDAADAAMYQAKRLSRGAQFTAGAEHPVDSVQT
RS
>A0A5E7JR08|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLDPAPWVWVLMLLNGVLWPHVAYQ
WARRAKVPFHAEHRNILMDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQVLGIGVGWLIFTPLFIPQTTALQLYACLPLLTLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQHQGGAVALIDIDHFKTINDTYGHVAGDI
VLRQLSKILKQNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFNPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRRELLDPV
>A0A3S4N9Z1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLDSRHSLSLKLLRVVLLAALAVGVVLSCAQIVFDAYKAKQAVSSDAQRILAMVRDPST
QAVYSLDREMAMQVLEGLFQHEAVRQASIGHPGEPMLAEKSRPLLDLPTRWLTDPILGQE
RTFSIRLIGRPPYSEYYGDLKITLDTAPYGENFVTTSEIIFISGILRALAMGLVLFLVYH
WMLTKPLSKIIEHLVSINPDRPSQHQLPLLKGHERNELGLWVTTANQLLASIESNSHLRR
EAEDNLLRISQYDFLTGLPNRQLLQQQLDQILDGAGRQQRRVAVLCLGLDDFKGINEQYT
YQLGDQLLIALADRLRGHSARLGSLARLGGDQFALVQADIEQPYEAAELAQSILDGLEAP
FEID
>A0A7X0KIC9|diguanylate cyclase|EC 2.7.7.65|Aminobacter aganoensis|TrEMBL
MTARILVVDDIPANVKLLEVRLLAEYFEVLTAYNGPDAIAACEAGKVDVVLLDIMMPGMD
GFEVCRRLKANPATAHIPVVMVTALDHVTDRVRGLEVGADDFLTKPVNDLQLVTRVKSLV
RLKVLTDELRLRASTTHSIGLDELLSRSELLQETIPKVLLIDEQTSSAAHICALLDGAAE
VQVAADPQSGLFNAAEGSYECVIVSTGFSDFDPLRLCSQLRSLDRTRSLPIVLLVRKEED
DRIIRGLELGINDYLVRPLDREELIARLRTQVRRKRYNDELRQSVSQTIEMAVTDGLTGL
HNRRYLDSHLPRLFDRAVARHRPLSLMITDLDRFKRINDTFGHDGGDEVLREFARRVKKS
VRGIDLACRFGGEEFVVVMPDTDGALAEMVAERIRAEVAQTPFAISGAGKSVSVTVSVGV
SSLLAKGDTVAGLMKRADLALYDAKTRGRNRVVARAA
>A0A448BWH5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDERASKPPGLLPLSREDLEKTLRYALEIVSDGIWDWNIATNQVSRSAGWYLMLGYPPHS
LPESVETWKSIIHPEDYPRVMASFQAYLDGESPEYCEEYRCRTYSGDYLWISDRGRFVEF
DERGEPRRMIGAHHDIHQRKLVELELQQRNEELFDWNLRLEELVAERTEALHRVNQALAS
KMAEAQRLSEIDPLTELYNRRKFEQCLHHEWMRRQRHGRATALVMIDVDHFKRINDLFGH
STGDRVLVAFGRLVASELREVDVLARWGGEEFILLLPETGLEAAAALAERLRQRVRSQSF
EMGERLTASFGVGVLNDGETLDLLLCRVDDALYRAKQRRDCVACC
>A0A5E7G3L3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKLFRSNSRPTLGSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFSDKTAANESLALIASAEEVADAQVLNSQGQVLAHWQRPENGLFSELEMQITR
ALLEKPISLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQSHLQSEN
ESLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKLNERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAIANRVRAQLREEDLVARLGGDEFAVLLTPLHKIEDAERIADKILASMDMPIAL
PGDTRVVTSLSIGIAVFPDHGATPGGLLNAADAAMYQAKRLSRGAQFTAGSEHPADPVQT
RS
>A0A379IBH4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQPSLIARRPISLAQLRQQLNLQLQTSLEAERILGLFF
REVQRLVPLDALQYRHEASDLRLEYGQRGHHSVSYSLSHQGEHLGELVFRRNQRFSEEEQ
GKLESLLASLLYPMRNTLLYRAATRSALRDPLTETGNRIAMDQTLGREIEMAKRHLHPLS
LLMLDIDHFKRINDSHGHTTGDKVLKAVAASIKGQLRNVDMVFRFGGEEFLILLSNTARD
AAAMVGERLRQAAQTQEYRADTTRIELTVSLGCATLLAGESAESLLRRADNALYVAKREG
RNRLAMAG
>A0A379I5D4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVHETDSPTSTTPDSTDTSRSAAAATLLALMHAQGEVERLSEREQLLSSLLVSVNAVLWA
IEWETRRVLYVSPAYERIFGHSASLLLAEHRGWRDSIHPEDQQYAEHSLAQVLELGAVED
RQYRIITADGQIRWLSDKCFTNQQAAPGKPLIVVGIAEDITEKKHLELELQRLATTDVLT
RSSNRRHFFECAHHEFERACAQGLPLAFLLLDIDDFKAINDTYGHLQGDQVLLRIAESGR
GVLRRGDLFGRIGGEEFAAVLPGCTPERAMQVAERLGQEVRQLGFSHEGLPYSVTVSQGL
ANLTTEDTTLDSLFARADAAMYEAKRQGKNRVIAG
>A0A0M7A2J0|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MTLDTPTLLIALAAAEFASALILLAFLVSLKKANRATRLAFAIYAPAMFLVACGTVLVAF
RSEISAFWSITFANALFLIGFALRPEAIAVFYGRPARGWMLLAALSGWTVICIVPDFFAS
FTLRLIFVQSMLLAAAAYSVWRVFRLNSEHLTSVRLFMVGSFLEASAYLMTIGSQIIYQH
ESLKVFANPIQPLAYLVLLMVAIVIVSASFVAMAIERIQVRFEKQALTDSLTGLANRRAF
IKAAKRWFSSTAQTQAYTLILIDIDHFKSINDQFGHTAGDRVLASFGTAMKSIFARAIPP
GRIGGEEFAVLLPETEKADAVHLLGRLREVISQCAICPKSEASGITVSAGLITATTSHDF
EQAFDHADQLLYEAKKTGRNRHVALDKTVPSDELTIVNTANQPRGMVASL
>A0A736IDV8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z36[z38]:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSVQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A1C6DUC5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKIRLKMISLFLIIILIPLIFLYVYLSKISMDQVSASQVQALKNINETKADYIADVIHNL
SFNEKEFASSDYLKKYIERAELTLDDDYYRQINDSIRNTVKRNHLITDMFITSTSGTVLA
AYNINDIGSYCDRYKELDAAADSNNGISHIYGPTDSDTCSFYVVKRVYSGVSNQIGLVVE
RIDLTQICKSMSLTGYSNYASVLLVDSAGKYISSSVSYPKSLTTVAEYRKIGDNITDAIP
FYTTSSVTQTLSAEYDGKTVIGTSIPEAGWSVVSYYDNVLASGNISADFKSAKFAVVIFC
ITTSALAILICITYTEPLSKIIRVINQKNKGDTTIRLELNTNDEFGEIGSAFNTMFDSIY
ESEQRYKTVVSMMDNVVFEINLKACTVYVSNNFNQKFSFRAQTDSISNSFLYKMKVHKDD
IKRFNDDVEKILIYEGEKWEGEYRLKNIYGDFSWFRIQGRKFKDQSGTPSKIIGMIADID
REKKSTINLMQKANYDALTQLFNRASFLRSLDEEMRQSESRRSLDALMFIDLDDFKHFND
EYGHKCGDDVLKFVAESIKELTSDRGFGGRLGGDEFVMCLTNLKLIGDAGKVADDMIKTL
NAGFKSESTGLQLNIHCSIGIAFFRENGSNPTELLESADTAMYKIKKSGKSNYAFADGVA
SSEEK
>A0A5C5ZC42|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MHGGDLISDVGKMFKSKLKPISVASRMAGKLVLLSGFTLSLVHLLGVIPDPNRAELQRKA
VLTESLAITSSLLALNHEDEIIKKNLSSILDRHPDVLSACIRRKNGTILHQIGDHERHWQ
LEPGANSNPNNICVPIAAGKREWGTVELSFNTDQGLFARLMQYPLVVVGLFTLVVNGVVF
RLYLARAFRYLDPSKSVPMHVRATLDTFSEGVVVLDNEQRIVLANDKFKKHIGKSEEELL
GKNIDQLPWESDDDDEVTLRWHSDDDSAKTVRLGLSFEHEHRTYLVNASPILGNDGQRRG
TIASFDDITPMEEKRKELSKMLSELQLSRDELKLRNEELNHLATRDPLTGCLNRRTFFEI
FDKEFKASQRHQQPLSCFMVDVDHFKMVNDNHGHSVGDVVLRCIATAIEENGRDSDVVCR
YGGEEFCVILPHTDANQASVVAQRIRSTIEQLEFEKFITTVSIGMSSATFGASDPQELLE
QADKALYAAKRGGRNKVVRWEEIANSNDAESPNEREMDNSGLCLSNSPSIPYPAVASLMS
ALAYRDASTATHCTRVAELCVATASGLLSVKETYVLEVAALLHDIGKIGVPDAILLKPGP
LTPEEWEMMELHDRIGVEIVEASFSHPELVDIVKYHHATFESDGNSKLPSKHDIPIGARI
VTIADAYDAMVSDRVYRKGRPIEDAFKELRRCAGTQFDPELVERFIASVRTHKSVDLPVQ
SRQVALQLGLQIERLADAVDEQDCISIKAIASRLEATAAAGGIPEIEDLASGIRHAATED
KDLFSLFTMVGQLISLCRSAQKIHARTSFKGDENCIADSDDAQSRHQLAK
>A0A518GLM5|diguanylate cyclase|EC 2.7.7.65|Planctopirus ephydatiae|TrEMBL
MLPSSFTKPKFALDAQDQPGHREPFSWWNRSGKSREKSVSRLKTSHPWIHQLVVWVIVVA
ILLRCLLAAPGEFRWIFPVAFAAIAYYATAIWPWLFAGLGTAYMTFQSIWRPGISTGSTI
SLLAVCLLSAVWGQHLRNQLIAEQVRSRRDPVTGLLNARGFEEILQEWILISCKEQHPFA
VVYIDCDRFKTVNDEQGHQVGDALLKIVGEVLSQNIRQEDAAARLGGDEFAILIADMDEI
QVLSLVEKLLANLRAQVTNARTATTFSVGVVLFSEIVPDPITCLSLADQAMYHVKRHGRD
GIHVERYPRKD
>A0A8D9UND2|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAVLEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A1R4B4K9|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MVTRFEAEPVHDAELEQQAFDLLLSYRDAQFTELNHLLMMAASCVRSEDIRVTIGNRDRS
KVVATYFPSRGQAEDRLQDHIRVSARVMSLSSDNSVYEEELKHITHQSIMATALSDGNRS
VIGAVTMIFDENLVDRASIESKVRLLASSVGGLVNSQFNAIRAQLAQQSERRARDLAMRK
ERLLEEVANVSGVGGWEFDVVTQELFWTRKTREIHEVDDRYIPSLDTAYDFYPEQSRSII
TQVVEDGLKKHGIWDVEVPFVTAKGRQIWVKATGFGVYEGEELQRLIGGFQDITARKRQD
DLLEEKEREARAQRNEFSAILANMSQGIAVYDAEAKLKYWNQRYLKILQLTENDITIGMT
FCQIIKHLTDVNLLSGDITTLINRMQMNFELNKELRMKYRLGAESVIDVIYTPLPDKGWV
TTVEDISNREAIAKQIKFNANHDSLTGLANRLLFNKALTKVITTEPQARPYQYTLLLLDL
DGFKAVNDNYGHIAGDEVLIEVSRRLHSIDETFEHCQSTTARLGGDEFAILLAHQKDTHA
LSEAKLVAQMIHRRLCRSYTIVGKDIHIGVSIGIAQLLDIDVELREWIHRADTAMYSVKK
SRKSGYHVSNDEERFDNES
>A0A1V5D5M9|diguanylate cyclase|EC 2.7.7.65|Syntrophorhabdus sp. PtaU1.Bin058|TrEMBL
MENHEKAQEQLIKELAGMRRRVADLERSEAKYRQIEKALQESEAKYRSIFENSVEAICQT
TREGNILMANPVFFRTLGYDSYDEMARSITNVYNDLYVNPEDRQRIMEVVKQYGAAGRFR
TQFYKKDGSKIWVSFSIWSVHDAQGKFLYYQSMGEDITELKAMEDALRKSEQECRGIFEN
AVMGIFRTSKDGHYLMINPAGARMYGYGSPEEMMQSVTDMAHQIYVRPEDRKTVTGLVER
NGFIEDYEVEHYTKDGGTIWASVNARVVRDATDAILYYETISQDITERKRLEQRLSAMSI
TDELTGLYNRRGFLTLTQQQLKIETRAKQDMLLFFTDLDNMKQINDTLGHKEGDRALIDV
AGIFKETFRESDIIGRMGGDEFAVFAINTTDETQKILTTRLQNNLDTFNDRSMRPYKLFL
SIGVAHYDPETPSSIDELITRADTLMYEQKKGKRHFV
>A0A4R8RYI5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MQNRQQLEPGFQYFLVTDALRGAGQLRQLKVGIGLLCFSIVVLAGATQFIPLGPQGAWPR
TIQAIAAAMAVIVGLCWILFPWPNRRGMVAFVAWADLTLAITAATFSDPTARLSAVVYLG
LVGLLPTFFLGRCALVAHCGFAVALFGALVTMNVLVDGATWFSQFTYGAPTLAAVVLMPT
IIQLVLEGGRDSILAAAVSANRDPLTGLLNRRGVTTAIDLLHRGRIDAVEVVVVLMDVNG
LKELNDTRGHGAGDAMLKAVAAMLTVSTRVGEIAARIGGDEFLVVAFPGRAENIDTTIRR
VSTPRAGIDTWSVSVGAAWQSQTGGKVDLDSLVQQADYELYKVKSSRRMLDPQH
>A0A7W8G1T4|diguanylate cyclase|EC 2.7.7.65|Chiayiivirga flava|TrEMBL
MSSPAPDAAPDGPARVDAPRRALPWQGLPRTVYLFRVLGMGLGLLPVSFVLRDLHAGWMP
WAWSLFACLLWPHLAFALARASRDPFRAERRNLYLDSIFAASLVPLMQFNLLPSVLLLVV
ATADKISTGIRGLWLRTLPAMAVALLVAGACTGFAWQPHTSMAVMLASLPILVIHTLAVA
LNGYRLIRKVQKQNQRLDDLNRIDALTGLQSRAHWQQQAEAALHRSQQRTGASTLLLVDV
DRFKDINDHHGHAVGDDVLRAIADVVRRVAPAGSDAGRLGGDEYVVVLPTSLSLAESTAE
AIRAGVEGLRFPRLPSLRCSVSLGLAEPPAAGLTLREWLEAADRALYRAKAAGRNCTASR
DAVRTPQR
>A0A737C5P7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae serovar 18:z4,z32:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFPDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLLRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A136WEQ9|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MQGNKKFWRIFLIFVIFFGVVFFLIFDYSWRCKCFIEEQTYTALRKQAETVRNDFWQRLE
GEFTLLDSFSDYMGKEDDFSLEKIRDFKDENSFLQVFEKFAIADVETGLVEFEDGTYVDI
SQKKAYINAIRGERDIDYFQHDGADMGKLILATPIYQENRITGVLIAVLNDAVAEKQTPM
VSFEESGFVCVTDQQGNALRFAHPYESFDLQGNIFAYFDAKNVNTGEMISDMGNDLINSF
SYDNGEEKWYTAYIPLGINDWYIFCFAPNVLTTGVTGEFESMETFFIIQMFLLFGVACIF
IYFLMWRAATQIKKENECLKTAEEVAGVVSFEGNYQKDTFVVSDNYFKQFGRSPVWHKIS
DFGKPHPFILKEDQEAFLKMGQSLIAGKETGNVQYRFFGSDGKIQWNQFVYRVWYDRHGR
PKKCYGMIMPIDQQMKEISKLQTQVEKDPLTGVLNRMAFEFYVNHCFKEELGEQTHALLL
LDLDNFKQINDGYGHVLGDYALITTAELLKACVRNSDFVGRLGGDEFVVFLRNVNKEQAA
NKAGEICEALEKAEMKSNEAIVTCSIGIACFPKDGCNFSELYGRADQGLYKVKGSGKNSF
YMVD
>A0A4T0V1F9|diguanylate cyclase|EC 2.7.7.65|Crenobacter intestini|TrEMBL
MQQDVPTNPHYTREEWLRLIGETPPPLRALIRALAETHRAALADHFYRHMLATDEGRQFL
DHDTVNTRLRHSMQHWLVELFRCDGEADIDAAIAHQRHVGEVHARIHLPVHLMTRGARQL
RQQLYRLLAAQDLPRQALTRAHAYVCETIDLAMELMNAAYTRSTARQTRTEEAYRHYALG
QNLSLERERQRASLLDWSQNVLFSLHLHDASAPLPSLGRSEFGMWLSHKAEVIFERSDEL
EQIEAQLERVDSIVLPRLQQAADAGQRRLRSRELQETLDEIHFLLGTLFDRHVEVENGRD
ALTRLLNRRFLPAVLSREIQLHQRSQQQFGVLLIDLDHFKAINDTHGHEGGDRVLQQAAQ
LITACVRAGDFVFRYGGEEVLVVLVELGHDDLMRIAETLRGRFEAQAFTVTNGLEIRVSV
SIGVALHDGHPDYQYLIGRADDALYRAKRGGRNRVVDAGAMA
>A0A8H9PCW3|diguanylate cyclase|EC 2.7.7.65|Kluyvera intermedia|TrEMBL
MMKQNQRVLMATPNLILRLFSLGLLSFIFSLFSLELTHFGTHLSPLWFPSALMMVAFYRH
AGKMWPGIAVVCSVGSVAATMVMFPASTLNLWYTVINVIEAVTGAMLLRKFLPWYNPLQN
LNDWIRLAIGSALIPPLLGGTLVCLIVPTDNLVRTFMLWFLSEAIGALALVPVGILFKPH
YLLRHRKRQLLLETLATLAVTLGLSWLAMNYLPWPFTAVIVLLMWSAIRLPRMEAFLIFL
ITVMMVSLVVAANPLVPVTPKTSVMLNAPWLPFLMILLPANVMTMVMYAFRAERKHISES
EERFRNAMEYSAIGMALVGIDGQWLQANKALCNFLGYTQDELRLMTFQQLTWPEDLNKDL
EQLDLLVRGEINTYSQEKRYYTRSGDLVWALLAVSVVRHADGSPRYFIAQVEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWELEPDIISWDKRMFELYEVPSHIKPTWQLWYERIL
PEDREETERIIRDSLMSRIAFKLEFRIAVKDGIRHIRTLANRVLNRNGEVERLLGVNMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWSQDQAMSQPL
LNVLRITFGESGPAMENIHSGDMSRTAIEQDVVLHCRTGGTYDIHYSVTPLSTLDGQNIG
FVLVIQDVTESRKMLRQLSYSASHDALTHLANRVNFETHLKRLLKSVQELHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDILARLGGDEFGLLLPDCNVESARYI
SGRIIEAINDYHFMWEGRMHRIGASAGITIIDETNHQASEVMSQADIACYASKNNGRGLV
TVYEALQGQMLQERSKMSLEEQWRMIKDNHIMMIARCVASPRVPETCNFWLLSLRLWTSE
GEAMEERAFRAGLNEPELIRALDRRVFHEFFRNHATAVAAKGLGVALPFSAAGLSNSKLV
EEVLDLLERGPMPGRLLHLMINADALMRQGKEIIDNLKKLRHAGCRIILSHIGHDLEIFN
HLTPHTADYLLLDQELVTNVHGNLMDEMMVTIIQGHAQRLGLKSIAGPTNQPMMMDTLSG
IGIDLIFGDTISQPQPLDIMLNTSYFAIN
>A0A210P9X3|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MTWAHLSIDLPLFLIRVVIVSFFSIGFIQFFQRLWNKAFDKKDISQNKRWTARILLTLIT
AGLGTLIHLDAMFFIHNNSAIIYHNWALFILILPLLFGGFSKIETGIQILALIEIWYMHH
ATNFFQVVPLVAFVIFLAATIVLKIYHKKIMKNWGIGTLSAIFISSIFWFTVPKQSMGMT
FTLEWKIQAVILYTLMITFVLGYWIRQYQEDQRKRQLERLADYERGIEHNSYADHQTELQ
KMFSDAKQSKTNLSFATFDLDNMKLINNRFGRLAGNEVLSGVSRMMKQILNNSNLEYQLF
LTSGEEYNIVFPNNEVETVLPIVKACWQGIRKSEFAYNDRNISVTTSVGLTTIHSEDTTV
NNIYKRADDALLRSKQYGRDTITLDKKLYQVFKNRLKNYLTIVTLPKISMMYLKLNQVCI
ITNFFFEHTILTKNVGFFLTTSKSPYGCRLPY
>W1XCL0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli DORA_A_5_14_21|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEQDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>I6DMS5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEA
ILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPA
NPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAR
ELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLP
NKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRM
ILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDL
TAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQP
QVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQ
ERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAIL
RPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLA
QSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A7Z0VQT0|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MLNDICRSLLKKGFQTDLENTRIEYNELGTLFLLGIGVIGATSMLLLPWFELKWMVYLFV
GYAFIIPAINLFISSGLVLWFSMLQSPVSYALLLALQWILPTDMVYLTGFIYPISFVFTF
HFYRPAYYLTNLIVVFGLTAWVLFLRQVPYWDVFVITTFGGTLTIGLVVNNLVTKILKLA
NYDALTGLANRRHWEAIVAHLIALARREEHPLSIVFFDLDDFKKINDKLGRMAGDKVLIK
VSRQLIRISRDADMVARWGGDEFALALPNTDKQQAEAMMSRLTTELGDISVSHGIVLLQA
DDTLATLLARADKSMYSAKLEKHNGNRQVQLFGI
>A0A240EH79|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MTKDLLIDAHKGMNLLLKELALGLPKNQLEKRIIKLTERLFKDKRASILTLNQDTHRLYS
TSAPNLPDFYNEAIDGIEIGEGVGSCGAAAYLKCTFIVQDVTEHANWQPFADLAKRAEIG
ACWSVPVISTQEHVLGTFALYSAMPSEPHAIELEILESIAAVYSVALEKYALEDKLNYQA
KFDSLTHCLNRRALLERVEQSHCFQGHFLGCFFIDIDKFKQVNDIYGHQFGDQVLVAVAQ
KLQLLLPVQALLGRYGGDEFLAFSCFPSQEDARSFYETLQSELNTPVTLEDTNIGVSVGF
ATKECCSDITIDQLIRSADNEMYKVKRKAKLESLFLSRC
>A0A240EHI3|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MLELILSAHQGSTEELLGLSEVFDAVDAYIFIKDNKGKYQYVNRKVLDNFEITMKGIKGK
TDWHLFNFGVAKKMRLNDKKVMRTKKPMQQKIPFHIDNQELYHLTVSSPIIKNGKVLGVI
GFAVDVSKDMEERQTLLEEANTDGLTGCFNRRYLHLALEQQRQNFTHNKTPSSLLIIDVD
RFKPINDKYGHSVGDRVLIDVVQVIKRFTREEDMLCRYGGDEFVLLLPGSNIEQAYTLAE
RLSEKIDNLSFTFTSSSGRSFSVSCSIGVATHTIEETNIVELADKALYVSKKGCSGKVHM
HCPDTQKIVHCHYCDEEVSA
>A0A7Z0VKA2|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MKINMVLMLLAGILVVMAISFQWKISSDAAYASELEAQYQQAMDDYNENNIYYSPQATTQ
WIVQRQNPAGYFVTNPDMLFEPSQLNNSTLRGTRYAISTLGDLNGLHTINRHAVIDFILG
LYETEIKQTRVETYTRYQRGTRYDGFKTLPGQDVGVRPTMDALMILNRLDLLDDPRLNLD
GIWNFIVAHQNEDGGFWDEHYPKLLKDSSMKCTSFAARALAILSQHTGRPIPEKLSKGVI
RFVQNNHDIVTGGYSSQPGENSDDSYNAFRAFKSIWDTTNGSDEIKRQAVSDSIDMNALI
DYFNYNHYLVELGGYSRHSNLENKKASIKATHLTVWLLHNMQLLDYVDKQSISKYVMSMK
TPDGQYGGDIYTTYSAIGLLQKMGIPSAPKPEPEKPEKPAIIPSIVPTTFFITALITLHL
GYQTKKFEFKTINKALIIQASTDALTGIYNRQCFEQKLKHEIEKSLRYKRPLTTIMFDID
NFKRINDKHGHIAGDTVLKEISVLIKDALRDSDIFARWGGEEFIILSTETDIDGGRQLAK
KMLDLINEKEFTVVQKISASFGVTEFCAEDSMESLVKRVDNAMLEAKRQGKNRIISVDAK
LNCQPACLTSGL
>A0A240EMN0|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MTLYRQLVVGMIAVFIMLLTSVFIIEFNTTKNFLEQQQRSEVNNTINTVGLALAPYLKTQ
DKVAVESVINALFDGSTYSTVKLVFLETDEKIVRSYPIKPNGVPDWFTNLNLFTPIHDSR
VVTSGWLQLAEVEIISHPGEAYAQLWQAFERLAGAFVVIFTLGLLSIALILRRALTPLRA
IVTKMEQVANKQFGEPLLRPNTRDLIAVVDGINSMSAHVEESFKQQAKEAQKLRERAYMD
PVSQLGNRAFFMGQLNQWLSESSLGGVAILHAEFIKQTYKADGYEAGDGLVRELSDLLSM
TINIPNTVISRISTDEFGFVFPNIDESELKFAANSIITCIQDLNADPTGLSKANASLGVV
FNEERKNSTQMLSVLDNALTKAKSNPEIDYGYISSEHTGVIMGKQQWRLLVEEAISNDAV
TFRFQAANSSGGETYHREVFSAIEMNGERYTANQYLLALEQLDASHIFDEHVIMSVINKL
EREEMSDSMAINITPTSIAQPSFIRWISQVLAKHRDINDKLHFEIPESCFINNPHHTALF
CNAIRNEGAKFGVDNYGRNFQSLEYLNEFRPDYVKLDYLYTHQLDDEKQKFTLTSISRTA
HNLGIKAIASRVETQTQLDFLSEHFVDVFQGFIVDK
>A0A100J7Z2|diguanylate cyclase|EC 2.7.7.65|Streptomyces acidiscabies|TrEMBL
METESEPYVRLASLRQLHQAMADMNTARSLADTLQTVADGVVNALGYELACVNLVRNDGH
LVVAAFAGNPAAEALITGRVGSRDSWERRLAMGERWGDLVFIPHTEGWVLDDDDVPQWYT
DGPPPRFEDEWHPSDRLFAPMYTPPSQGGTCGELIGVLSVDRPRNGRLPGAWGREALQMY
AFQAAIAVSNARLRSNIQRALVRLEREQQALRASEESFRAAFENAPSGMAIAELGGEQHG
RILRTNDALCRLLGRPATAMRRYAFSDLAHPEDIGILLRTSAEGGRVELRLRRRDDTYVW
VSLRNSVVADAADGPRFLLTHIEDIEDRKRRELQLAHRASHDSLTGLPNSAELRARLSAR
ICQRPQSTHPAELDAMDRTYGPGAHDANGHGFDYHPTPTPTYDGYDHVHVIAPDESARDD
GTKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLGRAVRDGDTVARLGGDEFVILA
DGLGRADATDLAVRLRNEIIQPIRAEGRAVRVGASFGIGWAQCGMTADEVLKSADERMYV
EKRSRPKQHRRAG
>A0A8F4FSF2|diguanylate cyclase|EC 2.7.7.65|Aquihabitans sp. G128|TrEMBL
MTGEEHAPAARPLDAAAVLGAVPGVIVLIERDGTVRWVNEHVTSFSGHRPEELIGTNMLD
HLGASANPQALESIGYALDHAGVQLPTVLGFRAVDGSTIILEAIANNQFDEPSIAALVVH
LGPYDERAALDRVLGSLAAGDDPEVSFGHLHQVARGATLRAESAVVFGDGRAIASSPEAA
APIGARCHDPSATPWAVAATTGRAVVLPDVSSLAPAARAAARKAGFEACWAHPIGHVDDD
GVGAVLVIWRREPGWPEPNATTLADQLVRLGKLALDRDEHRHQLLHAARHDHLTGLANRA
RFYDVLAEHLAARHAPVGVLYVDLDRFKEVNDAFGHGHGDRVLQEVAVRLDAGVGPTATV
ARLGGDEFGICQPGSDTSMLTATAERLLAALEAPIPVGDQEHRIGATIGIALSAATRPTS
TDHLVGRADAALVEGKASTKGTWHLAEVEGGAAPPPR
>A0A0X1U8R1|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MTNEWYEELLRCAEGMYVMKEESKEIVWVNRFFTDALKTPCVGELCWKVLLRRETPCPFC
PRLSEQDGVYVWDYYEPNSKRWMKVKHLVFRRDGVLYRAGNINMIDDVMHLNYETVQEIS
MLQTVLAKNRDEMTSLTKEAIYDALTGLLNRNCFKMDLEREYVNVPGLGILYFDLNNLKA
TNDKYRHAAGDVLLRRLADVLRLVCAQAQHAKCYRVGGDEFVLVLSRSTKETLKRCAKMF
DGYMDNYNRNQTYFCSVAMGQAFSQDPCDPELLVSKADDDMYYCKQKMKEKIQERFL
>A0A3S4HTX3|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MDGLESLLQELEGIADDPSLNVFMPKLRAFMIKLELQSQQEGRLATGLANLLKLMLDNVA
ELNRSDEYLLGQVGSLQEILSHEPLSMQQIYQLETSLKEVIRKQGMLKSSLDEAASSLRA
LLDRFVSRLALMTDSTDEFHGKIQAHSEKLKQMPNVDELGGIIGSLMEDTSIMQLDLTRS
RDELVSAKEQVEAAEHRIRELETALEAASAKVKEDQLTGAYNRRGLAEYFQREIGRAERT
AAPLSIALIDVDNFKQLNDRYGHLAGDDALKYLVDTIKHSLRPADIVARFGGEEFVILMP
DTPETEAVQTVQRLQRELTKTFFLANNDKLLITFSAGIARWHLGEQEADVLERADHAMYQ
AKINGKNRVCSAEDMPG
>A0A5K1IBU7|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MARIRDMWQTWSTQRAGRGSLAEVLLDDFPGVALLTDAYGVVLRVNPGCERYCGSPAKAL
IGRRITSLDVDPLHGDISHALAHCVARRRPWQGVLLCRRADGRLIHQDAVFQPLASGSSE
PLRLLVTLHDVTELRQRALHDHTLLERLQGTLSRLPGVVFQLRQDARGRLDFLYFSDGLR
ALAGLSAGAVMDRADALLERVQGEDREALVTSLAQSAVSLQPWELEFRLDTPEGPRWLEG
RASPTRRGDGITLWDGLLLCITSRKQEEQRTQRLVSTDMLTGVLNRRAFFDAGEAVRARA
ARQGRSVPLAMLDLDHFKRINDAHGHAVGDLTLQAFATTCRDCLRPYDLLARLGGEEFVV
MLVDTLPEDAWSVLDRLRAEVEAIEIEIADTTLRITVSLGLAVLPPEGSLDLALSQADQA
LYRAKHEGRNRLAGPTDVPGVREGEQQ
>A0A851GAA9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SECR19-1250|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A7Y9WM13|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia bryophila|TrEMBL
MDTPKPHRNAAAQDLAEDDANAQAQALEAEDAPNLAVDDALARILGNPPAAECPIMVLLV
DDQAIIAEAIRLALAGESSVDFHYCASPEEAVRCADETRATVILQDLVMPGTDGLTLVRQ
YRQNPATRDIPIIVLSTKEEPLVKSAAFAAGANDYLVKLPDRIELIARIRYHSRSYLNLL
QRDEAYQALRQSQQQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWRRAMRDKTGLG
FLMIDVDNFKAYNDTYGHVAGDEVLKRVAQTVEACLGRSPDLAARFGGEEFAVVLPGTSS
GGLRLLAEKIRIAIEGLAIPHAGSTSGVVTISIGAAMLVPSVAEPVTKLIEAADVGLYRA
KRDGKNQVAVSD
>A0A0U5MER6|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. XM-1|TrEMBL
MRPARSDAKSSDDSIGALPATEGRRIFDLVIRYGAGAVLLWTVLLGLSLWWTIGHQKDTT
FELALNTARSAFNKDLAYRRWASGHGGVYVEPSEKTPPSPWMSHLPDRDIIANDGRLLTL
MNPAYMLREMMADYGDDYGIKGRIVGIVYLNPNNEADSWEAEAIRQFSAGTITEKLEISA
LEGKPYLRLIKPFMMEESCQKCHGHLGFPNGSVRGAVGVSVPMEPYLEVESQAIRALAVS
HGGFWLVGVLGIGLIGRRSARRLKEKALADEETRLAAHVFRNALEATIITDPRGRILRIN
PMFTELTGYGEAEVVGGNPRIIRSDHHDADFYKEMWQAIYRDGRWQGEIWNRRKDGRVFV
AWESIVAVYDAAGAIRYFIGSFSDITEQVEAQRHILRLAHYDVLTDLPNRVLFQDRLERA
VVHALRHDRLAALLFLDLDGFKKVNDTMGHRAGNELLKEVAVRLRGCVRMTDTIARLGGD
EFTVILDEISSAGDAAVVAEKILAALRAPIAIDGREVFIGTSIGISLFPADGQSGDELLK
QADTAMYQAKAAGKGRFNFYSAEMTKREEHRLELEMALRQAVDEEQFHVHYQPKKNLAAG
RVSGFEALVRWQHPSLGMIAPLDFIPLAEEMHLVDRIDLLVMRQACRQGRIWLDQGHDVT
MAVNLSGVNFSVDDLPDQVRRVLDETGFPADHLELEITESFVIDLEVDQREVMQRLRALG
VMLAIDDFGTGYSSLSYLKRLPVNTLKIDRSFVRDIARDSRDMMLVSSIIGIAHSLGLKV
VAEGIEDSEQMSILETQECDEIQGYFIAKPMSAELAGIFMTGAPASHAVISG
>A0A1Y5T8V7|diguanylate cyclase|EC 2.7.7.65|Pseudooctadecabacter jejudonensis|TrEMBL
MKLKRNDARWIILMDVLTSFVAIAALWGAVVWLTTVANNMAQNQSRALMQSKLETVSTDL
SAVVRFIGFWDAAADWASLRDDQAVAANIGSTASERGPFDFVYILDSLGTPIYAFESGER
VVGEFYTNYELVNVARAAVRTTPIEPYTTVSGFVMSEDRLAMMSAGRIQAMDPAATEREL
APVLIGARWFTEQDIIKIGEAIGVDGLQVEYWNSVRRPGTIRTPLLDISDRAIAYVSWIA
PRPGDVLFDAAKPVLLLLSLIIFAASFFVGRTAARQTSAIVKQMTLARTDSMTGLMNRNG
LERRLSDPDVMDAIRLGHAAVIYFDLNSFKPLNDKFGHAAGDVALTMVGKRLVQSTRRGD
LVARVGGDEFLAVVFDENATSAAEAYVQRIDQKMLDPIRYDGEDIRLSLSHGISVAHPNS
TWEEIVREADVRMYEHKSTLKAARMPSAVA
>A0A840DXM0|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus voinovskiensis|TrEMBL
MVQSVLSNICILLLVYLCIQTIYFRKNDWTFLTPRRVKWLHILFVSFGTVAMFYTPIFIG
DYRFDLRTIPVTFLALLQGPSYAIPALVIASSWRWVLGGSGAVPGIVFGLMLPTILALYL
HRWSAIKRFSYVHSFFAFTAFWLLSDLPIIFLVPSGWEAFKQIAPIRFFSFHLGAALLFF
FVRLAIHHVQLIQKLRFYADHDPLTHLYNMRKFVEVVNEQRTPRYLAMIDVDFFKHINDT
YGHQNGDEVLKTLAQMIRTFAPDRMVAGRYGGEEFIACLSVEKETEAVELLNRLRTAIER
RTFFTIDGQPLPPITVSIGVAPFNCSNRIEKAIEQADQYLYIAKQTGRNKVVWGEVAEQV
K
>A0A2N7RB77|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MPRSSAVRFSHFLPSLLLLLAGLAAAYVKDLNVFFTSLFNVLPTLVLLLGGAYCAVYRRQ
RELFLMLTVYIAYFLLDTQTDYYRDNGKVREDAAVVFHLVCLLLPLLFGLFAAWQERTHL
FQDMVARFAVLLAFGSVALGLEQSYPQALLMWLSEIRWPALHGAWMSLIQMSYPVFLSAF
LLLAWQYWRNPRPLHAAQLVGLLGVFWMLPKTFILPFTLNIMCSQVMLMIAAAVAHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMSDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKISGGGRAYRYGGEEFALVFAGKTLEECMPHLEVIRESIASYNIQLRNQENRPQDDLQG
RQRRGGTGASSVSVTVSIGVAERVEQRTPEEVLKSADQALYSAKGAGRNCVMAFGQNRRG
AVRMDAAAG
>A0A3S9L2M3|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MDFGYAPQLYPEEYRYTPEGSANTALPTPDQGALVAIIQQLHSSLDPRTVFACFGNTLGQ
YLPLAGIQAQFADLAFSWGRRSGVSLRRHLNTEAFPGSTLDYRLIEPLTPAQIRTLQTLE
SMLIQPLLNAISYQKMSEQAMFDSLTGLGNRHFYGQAIKNAVARANRHHDKLALIVLDLD
NFKHLNDNFGHQFGDAVLRQFGALIKSAIRNTDQAFRIGGDEFVIIVRGELDSAAILCER
VLAKLNKGGFFSRNRIHTSLGAAQILAGENQDNLYERADKALYQAKAAGRNCYRLSLDTQ
NT
>A0A644X117|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MIRNPQSKDTSAEEPIPQARLDALLWKLDFLETIINELPNPVFAKNSDARFCFFNKAYES
FFSVRREDLLNRTVLELDYLSPEERWQYQKEDEEAIRSGGEVHYETSYQTDRGLCSSLYW
AKGFVTTGFEQKGLVGVIVDISSLKRLEQELANRVKELEEVRQELRQLSLTDELTTLPNR
RLFEMRLQEEVLIANRHNVTISLFMVDIDYFKNINDRFGHDAGDAILCDLAKILNRTCRE
SDTVARFGGDEFIGLLPLVCLHDARTLAERICKTVKDSCVQPDGRPLTVSIGIAEFQCGE
SGEQFKKRVDAALYRAKKNGRDQVSE
>A0A645GS72|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MMDVDGFKQINDTYGHFYGDGVLTYVSQILKASCKNTNAFLARYGGDEFCIVLPPNQEVD
AEEIIARVHSNVANWNQTHPELRPIGLSIGYAEWDQKLDISYESLLARADERMYSVKNAK
KRT
>A0A0U1HX62|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MNSHTYDQLLKSKHRLSLLLFLFLNAASAIFSMILPAPKMPAMTLPLAMITVISLGAATY
LIFISKNYADKLNLFAIVLGLLWAWHIILKFESLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTIPPALTVIFLDDFQNIFRIVFTIMLPLIGFSLHHLMLRRSDKFTRKLVAHLY
NEREKFSDLSMIDPLTGLYNRRGFENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAVAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYATQLAERVRQRVLSLDIPH
VFNHKVSTSVTLSAGVSPLQSYDLTSSLKAADEALYRAKKDGRNKVAFAEEKQPNAESTL
R
>A0A645H743|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MSGQVGRPGDLVARYGGEEFAILLPLTERRAARLMAEELRCLIEGLHLAHPHSLVAPVVT
ISIGGMTLTPTGGQVLPELFNRADAALYEAKRQGRNRVFWQDGD
>A0A645JMC3|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MFNRNYLEILIDFESQNARKEHYPVSAILIDVDNFKYFNDQYGHDFGDKVLSGVSTLMAG
KLRESDYIGRYGGDEFLILLPRLAKEEATGVAQRILDALPCLNIEGSREAIGVSMGIAEH
AADADLRATIKLADDAMFRAKKNGGNQYSF
>A0A0U1HUS8|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MPYSIRINTRRAGLSFAKRTYLPRIFGLGIGVLCVGSVLYAQNAEIWLWLMLVINGLAWP
HIAYLLALRSEQPFDQEITNMKIDSALGGVWVAIMSFNALPSVVILSMMNMNNIASGGKT
VFYKGLALQIACSLLTAWIFNLPFKPETSSLQVYACLPMIVIYPSLLGLVTYRTARRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLVRIQEKLAGLVF
TQAPLLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A822PRN1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A7W3BPC4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00271|TrEMBL
MNKGPSPIKRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RTLEAALVFSDSVAASETLAALGQQGQFSVAEVRNQKQKVIATWRYDAQDTTDKISGIIS
HWLFPQPVTQPILHNGDVIGEVRLIARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICTALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKNLRAERIIKK
>A0A822PNS6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAV
VCIDMAMKITFMNPAAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAI
EQDVVLHCRNGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALT
HLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLML
SMLRSSDVLARLGGDEFGLLLPDCNIESARFIATRIISAVNDYHFIWEGRVHRVGASAGI
TLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAAMSLDEQWRMIKE
NQLMMIAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQKFRRSFSDPALSHALDRRVFH
EFFQQAAKAVASKGISIALPLSVAGLSSATLVNDLLEQLENSPLPPRLLHLIIPAEAILD
HAESVQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITI
IQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A7W6LDK7|diguanylate cyclase|EC 2.7.7.65|Rhizobium rhizoryzae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAENGFKALEIVANTHVDVILLDIMMPGMD
GFEVCERLKANPKTMHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLVARVKSLV
RLKTLSDELRIRADTARTIGFEDLTRFDGFDISGQVLLVDGRGSSQERIIRALKPVAEVT
AMSDPQAAIFEAAESPVDLVIINDNIEDYDPLRLCSQLRLLERTRFLPLLLITESGREDL
IVRALDLGVNDYLTRPLDPNELVARTLTQIRRKRFNDKLRSSVRQTIELAVTDGLTGLHN
RRYLDNHLKTLFNRAAARSRPLSVCITDIDRFKSVNDTYGHDAGDEILREFARRIRSTVR
GADLACRYGGEEFVVVMPDTDAHSAASIAERLRGIIEAAPFALPSGGSLQITASLGIASF
TAGVETPEQLLKNADRALYEAKNSGRNRVVAAAA
>A0A5P9GMN1|diguanylate cyclase|EC 2.7.7.65|Erythrobacter sp. THAF29|TrEMBL
MKMGLSDVEGRVLHGLVEEASGDIVLRLDANGFIVFASENVAEIGLDLSGLLVMPHIADL
AEADHKSALSDFTHSVFRGDAPRGWFEFPILACSPEDECGAAECRRWYALSLRRIEGDGG
ETHGALGLLRSIQHKRSLEGELHSRAVTDPLTGLANRHAFCASLRRHLAHGGGEMIAIFA
VDRMRALFLQFGQRTADEIMWGFAKFLETMMLPGQEIAQIDNERLAVILPDMSPRTAREW
AQDVLSTFSSLTLPSSSRAPQLTASAGLARVECTVDWTLRQAELALVMARAGGGMQVGHC
GRQGGAGYGGYYTGQPPANATGEVDEVGVAARAR
>A0A5H8HJE8|diguanylate cyclase|EC 2.7.7.65|Salmonella blockley|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A655WAU3|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLLNAFSRRVFLWLGWLLISTSSLAATSTTYKVATEADDVVTRVLFDSIAHHFNLEIEYV
NYPSFNDILVAIETGNADFAANITYTDLRAQRFDFSRPTNIEYTYLYSYGGLRLPELRLV
GIPKGTTYGTLLKEHYPYIQQVEYEGHLEALTLLESGRVDGVVDAINQLKPMLLKGLDVQ
LLNDQLPIQPVSIVTPKGKHSALLGKIEKYAHSAHVQRLLRESIQKYQLDIRKQALRQSV
VESGLNVQRVLRVKLENNPQYALYQPDGSVRGISADVVFQACEMLLLKCELVSNGQETWE
SMFDDLQDKSIDILAPITVSQQRKNLAYFSESYYHPQAILVKREHYKDDVYSNVSELVAE
RIGVIKDDFFEELLQQMLPNKILFSYASQEEKVQALLNKEVDYIVLNRANFNLLLRESTE
MLPIVEDTMIGSFYQYDIAIGFAKNPLGATLAPLFSRAIKMLNTEQIIHTYDYQPNWRAT
LLAEKKYQRSTQWLFAMAFIVLFMVAFYLHGISHTDNLTKLRNRRALYNRYRRGLSPRLS
LVYLDVNTFKSINDQYGHEVGDKVLKQLAQRIEAVWRGRSYRIGGDEFILIGECSAKRLE
HVVAQCERFMFVDAERDVSFEVSVAIGIAKNRERTESLNEVMHQADIAMYRAKAESTQSP
FQAASKVKGLHIV
>A0A174YV98|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MRRYELDTSYQGNMPNEVEFTLDNRYVVKIGDERFYNLMGETMLSAFNGLVHPDDVMGFE
QFINSDMSVRYYIVRCLIKNGSYRWMLLVKKRIYEVGTDRMVELVAQDIIVISNDFDMYY
HRVRKYRAIINVIDEKIFEYDPVSGMITIYCYRNNKSEIFERTSLKEWKEACITKGFVTG
DDAVQFEALCTAIASGMNNFIVKLSSSVMSKGERVDNLIFRGQSLLADGENRITVGVISE
PDRRTRTVQEYVGVDEAKLDLATGIYNKKTVTDMITDDINKTAVSDRNRQMFLMILDIDN
FKSVNDSYGHYFGDEVIKAFADSLKLSVGGRGIVGRIGGDEFIVLIKDVTIEELRIMLKA
MRKGLKVSLAQKQPEYMFSTSIGIAQFGKDGSDFETLFKIADAALYIAKEKGKDRYIIYD
YNKHGDILADMKHDIAFGSGFMKPMAKYELATNIVMKVSLGMMTVKEVLSELTDKLNIHG
ISIYSGNDMECIYSTGHYKNNVIEAAYVNDDKFVNHFDEYGVNMVNNIASLTIEFPEVFR
KLRDNNICSFLQMKADGADGKEYMVEFDIFGTNRRKWSDTDVIMLRMVVLGVVNAISGQL
TD
>A0A655VSU7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNRRAFKQQLSHALIKAKRSNMKLALLFFDLDKFKEINDTKGHEVGDLVLQEIAQRLKGS
IRESDFCGRLGGDEFVVCLDLLQDHSGVINKAYQMLEKLQKPLQLNQESLEIGVSIGVAL
YPEQATQVPELLRIADEAMYTAKHQSGNTVYCAHQDKHDHTSLVS
>A0A109LIG4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSRDKVRPTLRSVIARGHMILALVAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVAQAEVFDINGKLLARWVRPETGMLSRVELQIAHAL
LEQPISQPILRQGQTVGSIHLVGHGGSLLRFLLSGLIGILICTALSAWVALHLSRRLLNG
ITVPLQRLAAVAHAARSERDFDRRVPSAQIAELDSLGSDFNALLGEMEAWQSHLQSENET
LAHQASHDSLTGLPNRAFFEGRLIRALRSAAKVNERVAVLFLDSDRFKDINDSFGHAAGD
AVLVAVADRVRAQLREDDLVARLGGDEFAVLLAPLHKAEDAQRIADKIIASMDMPIPLPG
DTQVLTSLSIGIAIYPEHGATPGALLNAADAAMYQAKRMSSGGQQTAESEHPVANVQHRS
>A0A1J9ZYJ9|diguanylate cyclase|EC 2.7.7.65|Bacillus pacificus|TrEMBL
MNILHFLLENTVFQNVLQDLQLNVLYIENGCTHQQTIENIHPKCMFIANSFEEGEVLFQR
TKPHIVIMYVTDFSQIKYIKNMYNPQSTFIVIWDQQITSEFAEVLTLGIRNIVIAPVTPQ
MVLEEVNKSLYQLSLVRQVSLQQELLQTMFDFRNDLLFIVEDDEIVDCNTNFLEFFGYEN
LFAYREQHLVFAEHLIRENGYYSTTHDITWLDDTLSYDRRIKMSNYEGEVSTFLLRATPL
PEDLSRFIVKCTEITELDEIYQEQERLAMIDSLTEIYNRLKFQQILEAEWDNAMRNNENI
ALILFDIDNFKAVNDTYGHDFGDLALIELAELMKSKVEQQHVFARWGGEEFIILVTNTVE
KEAFQVAESLRFFIETKQFSGISKLTASFGVALYEKGITREELMQRADIALYEAKKNGKN
QVCVYRKEKK
>A0A7Z1I9J4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A5M9IF50|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQPALLPRRPTTLVQTRQQLGMQLQTSLEPQRILAVFF
REVQHLVPLDALQYRHDASDLRLEFGQRGHHSVSYSLSHEGEHLGELVFRRNQRLLEEEL
GQLESLLSTLLYPMRNALLYRAATRSALRDPLTETGNRIAMDQTLQREIDMARRHLNPLS
LLMLDIDHFKTINDTHGHAAGDNVLRAVAGAIKSQLRNVDMVFRFGGEEFLILLSNTGRD
AAAMVGERLRQAAQAQDYWADGTRIELTVSLGCSTLLAAESAESLLRRADSALYVAKREG
RNRLAMAG
>A0A381H485|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MIKKTIEIDTILLDLNQSIDAHYQWLVKMFRCTVSGDVNQPDIFDINSHCLCQFSQWLNN
HPVHEPEEKGFVIKIIIAHEHMHTRGRELLRAIAEKRSEDHHFDRFQEALLAFTSAVMDY
KIYLLNIRSNMDILTGLPGRRVLDESFDRQLIDAQPLNLYLLLFDIDRFKLVNDNYGHLV
GDSVLRTLASNLSVWTRYDETPYRYGGEEFVIIIRTKTDEQACRAGLRICQLVADNPINY
PDGELSITVTAGITQAQQGEPLDVVIGRADRAMYRGKQTGRNRCMFMDKDQQITRV
>A0A8H0X6E0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAILAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A8G3CSH4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGEQSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A6H3G7T0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELNRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A3V7PDY5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0A8V9U2|diguanylate cyclase|EC 2.7.7.65|Yersinia ruckeri|TrEMBL
MNGHSYEQLLKSKHRLSLLLFLFLNASSSIFNMLLPAHNTPKLTIPVVMIAIISIVGLLY
IAFFPKNHAIKLNLFAFFFGILWAWQVTLKYEYLGRDENNFLLISLFTIFFISTIALSDN
FIAFCLHSAPAAIAVIVLDDFQNIFRIIFTIMLPLIGFCLHHLMLRRSDEFTRKLVDHLY
DEREKFSDLSMIDPLTGLYNRRGLENRLGMLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGFDIPH
VFNHKVSTTVTLSAGISPLHPTDLGASLKAADEALYQAKKNGRNKVEFASDTLASDTLTN
AESVH
>A0A174TQF6|diguanylate cyclase|EC 2.7.7.65|Enterocloster clostridioformis|TrEMBL
MWSRLKQFLGVIPDFPDFDEVIRALHGDVVKRNFLFHILIIMFECVMVISISMRPGGPFA
KPRRVTYFVLYLVLILAAAGVTWLETWIDRKKQADYRLYFRAEAVFLGFFSLWGVAVTLN
DQLGGNGLTVYNYVVLILAIMSMMKPWQAALLFLADFILLNGLLPCFPDPAGLDNSFNNL
MNSLFPTLAAAAVAASLYNSKLQAKRNEIIIRRQYRQIEAANQMLSREALSDALTNLGNR
NRFKKTIQAFEFDKQGCGTLGCIYIDVNGLHEINNHLGHQAGDQMLKTISDIFQEYFDSQ
DIFRIGGDEFVILCKNVGRGDLEHRTEQVRRRTEEAGFFLSTGLEWRESALDIEDVIQKA
ERAMQENKRGFYSSKGGERQKRELNQYMERLISEKKDADRFLSILAPVFEGVFFVNLETD
TVRQIFIPSYFQEMLEECGDKYSGALLLYADRMVEPQYASLFELCCDYSRLEAMLEGDEI
PDFTYRKKDGSRLRLRILKFYHYDSAGKETLWIFSDIEINYIEL
>A0A1S8QZY5|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKNISIKLKEVNFVALTGIIIISIILLTNFVKVLKYSYFELIDDDKYMNLSNNVEYFIP
KDNQYAEINQVADNSYIKFEKNNSKNIYFPEDVQKVWLKLRLQGIQASTDNIMYIDCEFI
ENIQFYIPTTDGKYVTEKPNEYFIFPYINLPENIDFNRDIYINSTWDSNVFNLLLAKDSN
FYIIQNLLACFYIGNLGVLLGMLIMNMILFFSSKDKKYLFHSLFTGSLLSLLYCLSGMQK
LILGFNSNNRLIALGAMAASTWVLFIYSYLDIKKHMPILNNFFKLSILFLVLSLYISKII
PDGFTYDILYLQMILVGLYILISIYSYFKFGMGSIYYLVGIFILFTGFIIYILGSYGLLE
WNIFAFSTCYPAASIETLLFTIGIIKQIKHEKEVNTKLQLEVITDKLTNIYNRRYFEETV
VNKILQLEKEKSLVSMLVLDIDHFKKVNDTYGHSTGDLVLSETAMIIKQCLRKEDILVRW
GGEEFVAVLPFTDSKESTIIAETIRLSIENHKFKFVNKITVSIGIAEKDVVEDFHSWFRR
ADNALYNAKENGRNTVCICYTNEIRNNS
>A0A3V5UNQ4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eastbourne|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A285B364|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MKLAGLHPDELRRLQSLRTSGLLNSGKEERFDRLTRLARTLYDLPVASISLVGENTLHVK
SCAGLEVDTLPRDITFCAHTILQTDPLIVNDLQQDLRFHDNPLVTEAPFIRFYAGYPVQL
PDGATVGAFCLMDHKPRAFSVHEIQILSDLAAIVEDEFKVLDAATADELTGLFNRRGFMS
LAEYALLTARRRNEPASLIFIDLDRFKLINDTWGHEQGDKALRAIADLMKATFRESDLIA
RQGGDEFIILLANTSQQTAGLAMEQLSKNVAEYNQQAGNPWQLAFSWGCVEYDPAAHHSL
NEIVAVADRRMYQAKSSHGAERR
>A0A7W3GXX5|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MDKLMWVEKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVAHE
FDSLLQFNIDRMIFFRNGMRSALGTPLDFAALRKAEEDYLTKRHDPIWSVEIHNRRTLPI
YGVADAFVDSDALLSRDNPFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
ELPKNSTQALALYSRATGAAWFTRQTQRNNPARGIVWQTFPDDESQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNRLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIQEGVRGDFGSITIALMLMWL
MFTLMLLISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERAIAETRLSERLK
RPVAVIQLDLDYFKSVNDRFGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TPLKEAQVIAERIRIRINSREILLGNSISLRITASLGVSGSDDTGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A7Z1EJX3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A8F5AC20|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MNDTSDTNPLEQDFSHFNADMLHTILELVSDGIWDWNANTGFVYRNPGWYEMLGYHRHAL
ENTVFTWENVIHPDDYPQVMKLFDDYIHRRAPHYQAEYRCRKKEGSYLWIEDRGYVIARN
ADGSVARMVGAHRDIHLRKCSVEQLEKRNQSLEALVAERTRELSRVNQQLQLQLDENRSL
AERDALTLVANRYRLEKVLLEECDRAQRFRLPLALIAIDIDNFKLINDRYGHGVGDQTLV
RVVECLESCIRPNDLLARWGGDEFVLVLPKTSLDIAKALAEHIRQTFRNRPQRDDFKVTL
SLGVAVRLTDEYPAALMARADQALYRAKAAGKDGVSE
>A0A658Y3P9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAV
VCIDMAMKITFMNPAAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAI
EQDVVLHCRNGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALT
HLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLML
SMLRSSDVLARLGGDEFGLLLPDCNIESARFIATRIISAVNDYHFIWEGRVHRVGASAGI
TLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAAMSLDEQWRMIKE
NQLMMIAHGVASPRIPEARNLWLISLKLWSCEGEIIDEQKFRRSFSDPALSHALDRRVFH
EFFQQAAKAVASKGISIALPLSVAGLSSATLVNDLLEQLENSPLPPRLLHLIIPAEAILD
HAESVQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITI
IQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A8F4WVZ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MENRRGKGLSFARRIYKPRIIGLGIGCISVAGALYPLAMPGWVWAFLLFNGFAWAHLAYQ
LSTRAQFPYQAEQRNLLYDSLWGGFWATATQFTPLTTVTILSMMTMNNVAAGGKRLFLRG
LLAQAAGIGVAGALFGFTFNPNVSLTQVYTCLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLHLKFHKCQQQQSHATIALIDIDHFKQINDTHGHIVGDA
VLRQLSLELRRNLRENDLAGRYGGDEFCVILPQVPLEEAAQVMERMRETFCNYRNPQIPE
LRVSLSIGLADFHPYFTDAAMWLNAADRALYAAKDTGRNRVNVSEEVIAHSA
>A0A6V7B963|diguanylate cyclase|EC 2.7.7.65|Xanthomonas hortorum pv. vitians|TrEMBL
MTNEPLLERMVDLTAIRDADLLDLSLLRTVREVCAAEELSLLRIAPDGRTMAETRLREDG
RLSLTVAEIRDVQLRAQLADARGAGDVVQLEEDGRALLVYPMMEARGIRTCLRVGGSRVP
GTAEQAMLQGFARFFQNYRSLLDDAQRDALTGLRNRKTFDDVILRLFAGGAADASASESV
WLGIVDIDHFKRVNDSFGHLYGDEVLLLVAQLMQRAFRQDDLLFRFGGEEFVIVLRGVDR
DTAVSLFERFRLAVAEYAFPQVGKVTLSTGIVELTHGRLISQMMDEADKALYWAKQHGRN
RAEVYTELIASGQMQHLTQQVGSVDLF
>A0A7W3DDP5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWSFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGVMGMSALPTA
ALVMMVGMNMMGSGGCRLFIPGIALTLLSALVTLPLVGKVAVFNPDLVEWGLTLPVLVLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIIAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLEKLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
GRTEVAA
>A0A7H5AAJ1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNAFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRSGFFTTT
EPLKNSTQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDDASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLNRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLVISWLVIRRMVRNMSVLQTSLEWQAWHDGLTRLLNRGALFERATAETRLSERLK
RPVAVIQLDLDYFKSVNDRYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRIRINSREILLGNSKSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVSAEG
>A0A484RTP3|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MKHSTEVMALDWEHTHSRYSAEQCQLAQDVSARHTAALAEYFYDCMLADQGAAFFLSHEL
VQTRLRHSMQEWLLTVFDARDLAQFQAAVAYQYRIGEVHARIEIPVHFIIRGMRLLARRM
HELLHAEPAALPDAVLGACRYVSEVTLISVEIMCHAYETSHDRKSRAEEGYRLLALSQNI
GAEKERQRAALLDWENQLMFGLSANLPWQQLPRIRKSEFGLWFTHKASHAFEGASETRSI
LLQLAQVDSLIQTASHYPPGSAQRAQALQGIRDATQALAYLVECLFEQAGNLESGRDTLT
RLLNRKYLQVVMNKEIAYARKIGAPMSVLLADIDHFKLINDTHGHDGGDVVLQQVASLIS
TYSRGGDYTFRLGGEEFLIVLVDVDGPQALSVADALRRRVQERPVALPDGSRVQVTLSVG
VSGHSGHPDYQRLLKSADQALYAAKAAGRNRCVLAEDDTDVPASAPVSHAAGYRPVRAGV
R
>A0A5I4NIE1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agbeni|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3R0R3N2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7G6KC15|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIVDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A0D5YED6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRAIHIYDSEHHLIAQSFKLSSHTSVLEKWFDHWF
LNEPVHLTIYHHQQNVGELTLFGSSEKILQFLKMIMVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQILLDMFEDKDFDNKSALLFIDNNNFKSINDQFGHLAGDE
VLKEMAKRLQTRLRHQDFIARLGGDEFAVILHSITHADHLISIAENLLESCKEPLHLNDQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKTSEQHWFIYKPEN
>A0A2V3NIQ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A630KFX7|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVSHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0E1NGL5|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSELDSLSTLYRDACVTYATLSIGYFALSKNSPFSYNGEVWKRIVFGLIAGLVSLYLNQD
QWVISGEYFYSFELIPIILVTFYGGWLSGLTALVINFTFTGWVTLDNVLITIVIIPLLFS
KVWEKKSSHIFYTTIILIAIYRMLTAVLLVPNTLFWTQIVVYQLISALCLAICYHALNFK
ERHIYAYFAMKDRANIDKLTQLNNRSSADYRLNSINHNRQACGLLILDLDHFKSVNDTYG
HDAGDILLTEVGKLLMTAVRDEDFVGRYGGEEFIIITHSHDPQAIKVVAERIRQRVESLD
VQLPDGRKVKATISIGASLFLPGMSMLKALKMTDEALYQAKNQGRNQVVYSRLMPFSPLG
DRMVKDKRRRSL
>A0A0J8UY65|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SIWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAICTYLSMTGVISYAPLF
NFTAMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIARCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A0P8K917|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPVTRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDAVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISRFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGNRHSPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>A0A156IA92|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKVINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEFICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>W9BG95|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A7D6XXS8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFSNLKADAILTGMWIGLMGGNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A8B3V358|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MRIATITNWAYGVTVCLTIASGIVMLMASHADNVERQAVKQRQIFDQLTEEIEAETWMLS
DLARLYAIKKEPDVLKTYQAKEGELKNIERKLGQLKDTGATGEELALLYEGLKIVDDLQD
EQQAAIASVARGEEQQAIALLFGKIYELEMERAQSKIDHFRVLLDKRIIADVQAATNTSK
TLRTASEMMVGLTALLFLFVMGFILKHRVLRPVVRLSDVVHRLASQDYAVETPNFNQVDE
IGDMAQAIRIFRENGLARQRLEKERDADWAIRELLARMTQRLQGCENVSDVIEVAELFAP
NIAPGVAGRLYILDRNPWEMRCAAEWLSPQGEKNAFHPDQCWAIRRGQSHPPVNGEPDIG
CQHLPESQKDSSLCVPLIAQGEAIGLLSFQNITPETAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLRTQIAQAMRNDEPVSCMMIDIDHFKSINDRFGHEA
GDHVIKSVATIVQRAMHDAGLAFRFGGEEFLVLLTGADEEAAHACATEIYNGVHTLSLRY
GLAEIGPVDVSIGIASYPQHAQSDDLLRAADVALYRAKELGRSRIVSFSMLEAG
>A0A1S9H5V5|diguanylate cyclase|EC 2.7.7.65|Rhizobium laguerreae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVMTAADGYTALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPTDRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGIDDLTRAGEGRADETAQVLLVDGRANSQERIIKALKPVAD
VLALSDPQAALFEAAESAFDFVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLNVLFNRSMARGRPLSVLITDIDRFKHVNDTYGHDGGDEVLREFSNRVRST
IRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAIESAPFMLKHSGEALNVTASFGI
ASRIASVLTPGQLMKQADLALYEAKNTGRNRVVAAAA
>A0A378B855|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDTIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSPERRRSRDGAA
>A0A3T9YBP0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRSVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V2I585|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDERQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1T8EK68|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MQHRALIIATVGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
LGPHGLWPRLIHGVLVASALAVGMCWIVLPWPRRRVAIAFVWWADISMVVGACTLSAPAS
RLGALAHMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLMGWNVRLGEATWFDQYVYSAPA
LSSVVLLPIIIQVVVEGGRRSLKAISLAAHQDPLTGLLNRRGVQVALGSLLSGQRATRIV
AVVLVDVDELKELNDRLGHDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFDHA
DEAAGLIERIGARRFGIGPHRASVSIGSAVRSTSVAGFDFESLRRAADEELRGAKIERRN
GFRAVP
>W8T0R2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A5N3D9H7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDIWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0K4UXL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGHMWPGIALSCSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAAAPLLLTTPRNDVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNDGRGRV
TVYEPQQATAHSERAVMPPDEQWLMIKENQLMMFAHGVASPRIPETYNLWLISLKLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPQLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMVDYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANVQPLDLLVDSRYFAIN
>A0A0V9KU92|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRVSAPF
NIH
>A0A0K4UKQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVMLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>J7Q6B4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A768UJ57|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
EPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANL
AALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQ
TYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQH
LAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVL
LLPRTPLDTALSLAETIRVSVAKVGISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYR
AKNDGRNRVLAA
>A0A376JYV1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQITDEALYIAKRRGRNRVELWKASL
>A0A066QE43|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A0F3T1S5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLDDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A827QC52|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENEILDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A828FWJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A376K0D9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSAPHC
>A0A023KY68|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2A3UYZ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIVMYQEKKHKQKTPFVAHSAPHS
>A0A777XMK5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPVLSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A4Q8IJJ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPFIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A827PYL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3L5GW78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTIQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A826ZHA7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5R1MKL9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRSDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A0K3XKG9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRESYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2X1NGQ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKSVTGDEYNAKNAIFTVSEAMEHFSYLPTGLYVFAYKKDVYFQVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A1C1YD01|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQERLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A2K4P2K5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNWQRFNKVSSFSGETSGIVKKNFIITAALLSSLFLAAIVSLLYIADNLNNKAEARSSLL
LQKALTNRQEKIRANLMDNADWGEAYNNLHKQVNVKWAWDSQNLGESLYTNYQYEGVFVL
SPAGETRYSVIEGNLVSQPFEKWLNRNITKELFNDLSQSQGKAVSRLMMTNGQLTLLAAA
RITSGDDESITPVAEDASVLIFADVLTPVKLEKMGNEYGIHNAHTFGRMEPHLKADYREA
QLILPIDNGDVLIEWRSDDPGRALMNRELPLIIILMLSTIAFTWLMRRGALIKAQINDEN
VFLLEQSRQALTASERRFRDVIEATTDWIWEADSEARLTWLSDRFSGVTGHHSDDWLGRN
MLDFIHSDKILFHHWLLNPQTSSNYTLKKARYFSAQGHQRYCNVVAKHAIMDDGSMGFRG
TVTDVTLEVEAQERAEYLSRHDELTGLPNRVRMKEFLEDELRSLPDPDHPLAMISLDLDK
FKPVNDLFGHNAGDALLNEVASRLRSCTRKIDLVARQGGDEFILILPDIYVRKDIGKVRI
SGEILLG
>A0A2Y8ZRW3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A0K3RB45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7B6F161|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWRIELNR
RRTLPVNGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A853T598|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MTDALPAAPPAALPEVLFSRLLEDALDAVIIIDEHCRIRYINGAMQALSGYASGELLGQT
LNGLLPDAVGAQHDNHVINYIRSSRTSSVLGKIREFAIRHRDAQMIPIEMKALDLGVVDG
IRYFGAFLLDVRERRELAAKNASLLAQLEQQALHDALTSLPNRRAYEAQAEQAMARAARS
GAALTVGVADLDHFKKINDRYGHAVGDAVLRTVAQALRDTGRITDVAARLGGEEFGLLFP
DASLRQAHKVAERIRAAVAAAITPLPDGGELQVTISIGVASLTAGASLDAAMSDADKALY
AAKHQGRNKVVAA
>A0A5N3D098|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSASSQKELPE
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5H9LZW3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sandiego|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377N2K9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRTVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3V7I8H9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weltevreden|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2G8Z5D7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8G2EBI9|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MPECHTPANRSIPSALARGTLLPALLVIVAVAVGCALVSPPIGTWREILANPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEMVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDTWGHLVGDEVLFSLGKQLAKLTSEQVLPARIGGEEFAIIVDGLSEPELHAL
AQSILDNARTILINHQAPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWA
>A0A738DWK4|diguanylate cyclase|EC 2.7.7.65|Salmonella abortus-equi|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTACGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSASEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A087ECE6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium tsurumiense|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYEVSAAASGEEGFDLFTRGGIDLVLLDVMLPGIDG
IALCRRIREQSRVPIIMLTAKGAEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
AVANDDGADRDDIDLVCGEIVMHVGQHEVTVRGESVFFPLKEFELLGYLMQNKGRVMTRH
QLIDRIWGSDYVGDTKTLDVHVKRIRSKIESNPAQPQYLTTVRGLGYKIDEPEH
>A0A5V4GT08|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHIVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2S8D754|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MPFYFRKECPLNSGYLSIRVSLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQN
VSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGD
LAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEI
GFSSGIYAMKENDTFEVA
>A0A2S8D573|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIHVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAVINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A622Y518|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDSRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSCSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y4JS49|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0D6F9P4|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2T8XYF4|diguanylate cyclase|EC 2.7.7.65|Salmonella infantis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0M0PZY8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A756XAK5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRLGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A750L661|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVTPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A754ATY3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTACGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSASEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5J1NPK7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rissen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A751ZZV8|diguanylate cyclase|EC 2.7.7.65|Salmonella dublin|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8G1HRS0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MSLFKPGSRPTLRSVIGRGHLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKVAATEALALIASTEEVADARVLDEKGRLLARWQRPESGLLSDLELQLAK
AFLEKPIDMPIVHQGREIGSIQLTGHGGSLMRFLLSGLMGIILCTAISAWVALYLARRQL
RGITGPLRSLAAVAHAARSDRAFDRRVPPADIAELDNLGNDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLMRALRNAHKLNERVAVLFLDSDRFKEINDSFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKTEDAERIADKILASMEEPIPL
PGHTQVLTSLSIGIAVYPDHGATPGALLNAADAAMYQAKRLSRGAQHTSGAEHPVAHVHT
RS
>A0A5C5D8Q0|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. B2|TrEMBL
MTININDLDYSLSELNIATKDHYDWAGELLRLSLLGGEGSRDIMDITSHHHCRFSKWLAL
RLTGEALDHQMILGIDQHHIEMHDIARELMLSIISKTVSEELVSQYHQAQRVFINSLDNY
KEYLVSYRNLHDALTGLPLRHLLYQEYPLILTRCERMNHNLYVLIMDIDRFKSINDTWGH
NAGDDVLRSVALTLKSATRKAERIYRFGGEEFVILLEAASDEDAQTAAERMREHLETHVI
MVDEQVINVTVTGGLTKVGASDSLHSSIGRADKAMYYGKNTGRNRCIMSTATEEMIAFG
>A0A853SEG1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MGDQQKRLQMALEAAHMAIWDSRIVDGQVIDGTVSWSAKGATLLGLEERALTQPFRSFLD
CVHTGDRGKVIKVLQDGVRRGGGYALQYRVVWPDGSEHWLAAKAHVFADAGGQPERTLGI
IWDITEHMARELMIAERKELAEVTLSSIGDGVITTDPQGKTRYLNRVAEQLTGWSNDMAR
GLDIGLTMPLADERTGEALEHVAMRCLQQRQAIGISPRSQLITRDGRRIAVEESAAPIWS
RDGEILGAVVVFRDVSHERKLSQQLSWQATHDALTGLINRREFEHLVAGALHTAKQDGHM
HALLYLDLDQFKVINDTSGHGAGDVLLQLLAKMLQARMRDSDILARLGGDELGVLLPHCP
LEHARQIGEQLRQSIRDFRFAWDNRSFELGVSIGIVEINQDSKSMSELLSAADQACYLAK
EQGRNRIHVYQESDVMLAQRHGEMLWISRLNEAFAHDYFRLYAMPIVHLHDSPEHHDEVL
IRIHNSQGDLILPGAFIPAAERYDMMLSIDRWVIRAVCHHIQSVRDSLPPLAALAESRRR
APALYSVNLSGMSLADAGLHDYITEQFVEFAIAPEQICFEITETAVIANLPKAQVFMRQL
KALGCRFSLDDFGSGFSSFGYLKALPVDYLKIDGVFVRDIATNAINRAMVKAINEVGHVM
GLKTVAEYVEDDATLAVIRELGIDYAQGYAVGSLRPLTAGID
>G4SVS2|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MSSIKQLAIEALQRGDFDFALQDVARGEADVSRLVEDLKIYHAELEIQNEELRQNQIITE
NAMRRFSSLFAALPVPALVIDEVVVIHECNAIAEQRFALSRKQLRSHYFPRLLPKKEHGR
LRELLQRARSEGSARVTGIELKTADEQQFIADMHLSLLSELAENYAQHFVVLIVDQTAAV
KQQVLLEESHRHFQAYFDSAPVGMAAISADKQWLEVNDKLCDLFGYSRDALIKLTWMDLT
HPGDLDAELVQFNDILTGKHEGYTLDKRCIRSDGEIIDVHVIKQGVRNAIGQLDYIVVII
EDVSVRKQAELALLERDQALENLSLSLRERIKELKAIYAISRASQLISDQDAFFADVLKL
LPMGMNYTDDVSVSINLPSKTYSNDTFSATMDKLESDIQVDAQVVGKISVGYRNPHILPN
NKPFLDDEKQFIEGIAELIGLFLTRIRSEQVQDLTSQRNAALLSLTRQATKMDEQSLLRF
ALEHAEALTDSHLAYVHFVNSDQNTISLGVWSGKTLQNCAAVHDNHYPLANAGVWADCFR
LRRPVIHNDYPALDNKKGLPEGHATLLRHVSVPVIEDDNVVMIMGVGNKQDSYDAGDLAI
LEMLANNAWALVQRNRQQRKLELDAMVFRYSREAVVVTDGEQRILSVNPAFTLITGYTET
EVLGLTPRLLKSGKHDDSFYQQMWAKLNLEDYWQGEIWNRRKNGEIYPQWLGISAARTTP
EGRPSEYIAVFMDITEHQQAREYIEFLAHHDPLTSLPNRTLLKDRFQQTVSYVQRQGKKL
GLLYLDLDHFKNVNDSLGHPIGDKLLLEVACRLRDCVREADTVSRLGGDEFVVLLGNVHH
VDNLADISTKILTALLRPFDIEGNKLQLSCSIGACLYPDDGEEFDGLLQKADTALYQAKF
NGRNTYKFYTESMNVAVMRRMSLENAMRLSLEREDFFVVYQPQFDIKSGQIVGAEALARW
HHAELGIISPAEFIPVAEECGLIVTLGQSVLRQACRQMQQWLLQGHYLRVSVNVSCVQFL
RHNLLQTVIEILEETGLPPHHLELELTESILVTDPEYVLQVVNTLNQRGVQFSIDDFGTG
YSSLSYLKRFAVDKLKIDQSFVRDIPGDADDEVLVEAIVNLAHNLRLKCIAEGVETQVQA
DFLRQLGCDQIQGYLLGRPLSVDAMQQLLSSQSR
>A0A1C5X9R0|diguanylate cyclase|EC 2.7.7.65|uncultured Roseburia sp|TrEMBL
MGKKFTIGVLIGNVHTAHPKDLMRGIRAAASGMDVNVIYFLGTQSVRFNQKFALEDFDYQ
YNTVYDYAKLAKVDVLIIAYGSLCIFQKNEDKQAFLDKFAGIPYVLLEDATDDPRGIYVM
VDNFGGMQKCVEHLIIEHHLKHLVYLGGPEDNQDAIERKAAFLNVMAEHHLPVTPEMMAV
GDYSEFVDNLVEQLLKDNPDAEAIISANDEMTVACYRVCKAHGLRIGKDILITGFDDVER
ARYSNPPLTTASQDAYKMGQIAVEKAVDICAGRPVESVRLDAELIIRESCGCKVTRRAKE
KADEKTELLHIIDELRLFQHKSWLGPFLIRDLMQEAENEKSFYRKSGEVFYHLGIRSSML
YLLEQPVTYENGQKWKMPQRMYLTMHQYRENIQVFEKQERPYIDGSFGVLDCCSSGEDHF
SYISFLLIDGKRQYGLLMLEIEPEEISFYYILALQLGTSLRFLEANIKQKKYRDRLREKN
EVLNFIAIYDELTGIYNRRGLMESLVRFNQDNLGKKACLMIADLDHLKEINDNFGHAEGD
CAIRTAAGIVKEVFGQYGDVGRFGGDEFAGIVRYSEMEEKEQLIYNIHQKCEQYNEHSMK
PYYVGISVGVVEFVCEKKIDFIEMFKHADEYLYEEKKKRRKTVCRNVNFENS
>A0A0X8HF07|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MKTPQWLSWRGASDTDAGSGADSRRFWLANCFLIIVALTSLVYTVVNFFLFEAILLAAVE
LAFFVIVVLALADMRVNRNIERSAWVTVLSCGGLSAFFYWYVKADVSAAVWTVFFAIINF
FLLGTRKGLPVYLVFFAVILSMTVAYREDWAALASGAALTNILGGMMAFGAAAYYQERSR
EAAHDRIEALANQDSLTGISNRRHFLQRFERDRQALCLLGGQYSLVLIDIDNFKSVNDTH
GHAVGDQVIIAVTRRILSAVRSQDLVARLGGEEFCVLFYDCGGSDAWRRAEELRRVVGAE
PVAVDSQSVMVTISAGVADGDPRSQGFNEMFADADRRLYAAKARGRDRVVGQLSP
>A0A8F9PG46|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQVLLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>A0A8F9PH17|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRRLRFPRKRIDCLPFGRGHWPVERARDCRKMDERASKPPGLLPLSREDLEKTLRYALEI
VSDGIWDWNIATNQVSRSAGWYLMLGYPPHSLPESVETWKSIIHPEDYPRVMASFQAYLD
GESPEYCEEYRCRTYSGDYLWISDRGRFVEFDERGEPRRMIGAHHEIHQRKLVELELQQR
NEELFDWNLRLEDLVAERTEALHRVNQALASKMAEAQRLSEIDPLTELYNRRKFEQCLHH
EWMRRQRHGRATALVMIDVDHFKRINDLFGHSTGDRVLVAFGRLVASELREVDVLARWGG
EEFILLLPETGLEAAAALAERLRQRVRSQSFEMGERLTASFGVGVLNDGETLDLLLCRVD
DALYRAKQRRDCVACC
>A0A8F9J4B2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHV
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2T3QGJ3|diguanylate cyclase|EC 2.7.7.65|Photobacterium damselae|TrEMBL
MGTLSQLSTRLISIVCISILVAAFFISSGTLSVVTSILTLVLIIMLLLEDFGKAMKLPLI
LALILYGFGVAIEILNQVPELREHPVLKNTDTVFVHLGVFMICFCLIKLLHQRHSLIKKL
NIQINKAKQLEGELSKQALQDDLTLLGNRRALFRRFDQLVLKHEKGMLAYIDIDNFKQVN
DMMGHKSGDHVLVQIAKILVKTAPIGSHYYRIGGDEFVVLFPTDDEKHIRDWIDTLYQQT
EELCQYYSINLSVGLAPYHQGNLSDPDSILVQADSAMYLDKSKKKISMR
>A0A8G7A162|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLKGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>T0PS75|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MSSTALSHLPPASQTPLFFRLDVRSQRLVALTDVMQTPLHWLDEPRSAWPAQLPDALRLP
IEQALAKGQGGKLMLRFAGQQWHIALSHEQDAFWLICLQTQRQEPIADLALQLPRLSQMA
SQQQFVAMLEALKESLGADRLILWHYQANGSLGSEQLTPVFALGAEGLSAIRGDSRYIRA
LRTRKSLSFSEAAHQPMLSQHYYLANAGVSSRLDGALLEQEKLIGVLSLEYLSATVLSEE
MLQLVRHSAQLLGHWQPEPEPLINPVLALPGELTLLTGIAYCRALVNWAVTMSGARIGWV
GEYQPRGQELWIIPRCVLEGETFSILKPIQLDPGPAQELFQHGQALYVEDLPLRYPHATQ
LLALNAKAYVGVPLHGPSGAPMGQLTLLLDAPLPDPMPLLDALSSQHERAAIELQRLAAD
DALRLAEVAFNTHDGLLVMDHQGIILKVNHSFGRITGFGNDEMIGQHIVRLRPTYYGDHL
KEDVRRAIDEQEFWMGEERCLHKDGHLFPVRLMVSGVKDELGEFSHYVCSFYDITKEKDA
ARHIEQLAYYDDLCGLYNRRSLNNIMQCTLQAPNGQWGALLLVDLDNFKSINDSLGHACG
DQLLQAVVERLKGLPQDNLVLARISGDEFALLFTALGQGYVTAKILAEHFARELMGLFRT
PFDIEDHKLHCSASVGISLFSSEDQDHLVLMQQADTATHMAKRAGQGNYVFFSEAMAEKE
KSKLTINNQLRDALRHHELQLHYQPQYRVDNGSLSGIEALLRWQRSDGTMVPPAEFIPIA
EETSLIQDIGYWVMKTACAQYSFWLNRGFAIPHLSVNVSARQFHTAGFVQQVEYILRDTG
VPPSRLLLEVTESVVLENRLESIARMRQLKDLGILLSIDDFGTGYSSLAYLRDLPADEVK
LDRSFIQTLVHSEQDKAIVKAILDLAKVFRFTVTAEGVEDEEQLAILKTLGCQHYQGFLT
SRPLTVKALESLLGAAQSG
>A0A8G5UIM9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGEATVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGC
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2D1QDU3|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MENTSSLNGLGHGIELWVRQMERLTPLASQDRNQLLELLLAQSDLDSLLATFADRAARVV
RIHSLYFDNPQPQRLIQQPPQASLTLHSYPFELRGQHGQLFGQLHYTLEHILSGSQQRIL
QQYHQLLCQPLPLYLRLAQLEQQVRLDHLTGLGNRSYFDEAIGRAVEQHSRESHGLVLVL
LDLDHFKQINDTWGHPVGDLVLSRFAHLLQSCIRSTDQAFRLGGDEFALLLQPAEPEAWR
PVWLRLQHMLLTHKELSTFSVGCSLGAASWQSGVAVQSLYEAADAHLYARKKAGKAGLLD
>T0PLK4|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MNISESAILGELQQILFRSFDVIPIPILISEAVCGDTLGTIPTTLSNIPIRHHRFVNQAF
SAQLGYTLAELPDMTAWFATVYHDEQTRTQAIQDWNQVVMTSLANGSAVAEMSTRIYCKN
GQRRWFTITAQLTADAMPGWHIVTFRDIHDLHCMIEEVSRLSCTDPLTELSNRRGAEQQL
QAHWLQGRPLSVVLCDVDHFKQVNDRYGHPAGDAALCGVARIMEEQLQGKECLARWGGEE
FLLILPGADASRAVSLAEQLRQLLSASQINWHHHHFSLTMSFGCATLTTGQSLDNLLLVA
DRALYQAKAQGRNRVLFGKE
>A0A4P0UGH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MTGLRVFWRLYRKSPPPPRIQYARLPHPPDETLRQKALDDMAVVDTPAEHYLDALVELAR
ETFAVKSVLVSLIDHDRQWFKARTGLDVEQTPRDLSFCAHAILASEPLMVTDASKDPRFH
DNPLVSGPPFIRFYAGEPLHASNGQAIGTLCLLDPAPRLLDLRESRQFKRLSILAEGYLQ
LRSLTEHTRFLRQEIGREQRRSLLDPLTQLWNRAGFDALHRHELELAQANEQNAGIIYSD
IDHFKRINDTYGHKAGDTVLREAASRLRAALRPEDLLARFGGEEFVALVRVRDHLELSVV
ANRIRELMEATPIDCAGTPVTMTISAGCTLARHAEELERSLARADAALYEAKRGGRNRVV
SA
>A0A7Z8MV23|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGKQGQFSQAILVDGRQKPFASWHNDGLARQDKVSDVIS
KWLFPEPTVQPILHQGKVIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLQDPLTGLANRAAFRNVINALMKDETVHGSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAVLLRNVHTEAEVQALCSALSEQFIPPFNL
HNGHTVRLSLSIGYALTWEHASAENLQELADQNMYRMKHQRLQRTQK
>A0A3E1SL00|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSKAILVDGRQKPFASWHNERLVRQDKISDVIS
KWLFPDPTVQPIWHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVHSSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAILLRDVHSETEVQALCRALSEQFIQPFNL
HNGHTTSLSLSIGYALTWEHASAENLQELADQNMYRMKHQRLQQTQK
>A0A1X7A7A1|diguanylate cyclase|EC 2.7.7.65|Roseovarius gaetbuli|TrEMBL
MVMRVKSQREVRFFAAAVSLVVLLGSLLLRVLILPPDLAAETILPGSLMAVMISAPIAFF
VGQRMLEVHEFAAKLEQAVYHDLLTGVCTRARFHERVTELGDESSVVIVADIDHFKGFND
QYGHHAGDLALRQFAAILAENCRADDIVARFGGEEFVVLLRDTSLSDGLIAAERLGRRVR
QKPVFVDQKALSLTASFGVAVLPPGGNAEAAIQQADRALYHAKHEGRDRAYVYDPARDAG
PLPANTAAE
>A0A1A6AVV1|diguanylate cyclase|EC 2.7.7.65|Clostridium ragsdalei P11|TrEMBL
MKISTIALFIATLFAKLVSNINDVNYTQNLIYIFRNCINILFFLAAYLGIGKYYKTALNL
VSDKTIRYMSLYPVTAFLLLITNFTTPTHIAHLRNFNSAYDMILFLLFILLGYILVFMGI
SSASQIVSMQCNLEKLELISKTDSLTGLYNRRYIMEKLENEFINYKKSKNKFSLILADID
YFKKINDSFGHDCGDQVLKAVAQNLHNAVRERGFVSRWGGEEFLILLPETEIHDAHILAN
KIRETIEKEIIEYNGIQLSITLTFGVTVNEDYETIGDTIKKADDALYTGKGEGRNCVVLS
>A0A1V6KAB2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin002|TrEMBL
MLQSASALSESEERYKLLFEASLDGVLLTAPNGRIFSANPALCRLLGRSEEEIIALGRGG
VVDREDPRLAEALAERDRTGKFAGELTMIHKEGTKIPVEITTAVFKDRFGQARTSMIIRD
ITRRLQEEEPLKKLQALLAETQRLSKIGGWECDLTTGLSRWTEEVYKIYGISPDAQLSAE
DAMDFYAPEDRPVIAAAFRRLLETGESYNLNLKFNNASGEPLRVRTSGQAEWKDGKIVRV
FGHIMDITERARMEDALRESEELFRNLFMRHEAVKLILDPETGDIIDANNAAEKFYGWSR
EQLLTMKIFDINTLTQAEIRKALQTVKDQKRTRFQFRHRRADGAIRDVEIFSSRIDVKGK
PLLHSIITDISERKAAEIRMLQINEELEQKVQQRTAELTRTIAQLEETNRVFVGRELKMA
ELKKRIEELEKSGKS
>A0A174V2J5|diguanylate cyclase|EC 2.7.7.65|Turicibacter sanguinis|TrEMBL
MIDLKVYETLAVNYIAMGDIEKGYFYFNEANNVAYQLRDAELTASFYQLFSETLLNYTNH
TSFPIYLLGEAVELTNDDYKKIQLRKQLASVYGLGGFSDLAINELIKALDMSVEEGYEDL
EIEILSQLSLLYYSNQQYQDSMRVLNRYFELSTDNPDIIYLSLWIQNYYYLYGYESIQEE
LKSLEEATSNLSIEQKIQYLIFIDFNQAFFLHSDGRYEECEMYIRRLQELKTQTTVSDLT
SLLIDKMKLDLEYDRGDQGIDYIKEYRRLLSDLQLTNDSVERKRLIIDNVLLHLLELGDY
ETVYQYTADLQKPVNQEVRAISFIMAMIQNSDNSHYLSKNNITSIVLKLGGYLLTALAGM
GVTYGAYRYSSYFKSLKRKAKESTIFDPLTKTLTKEALYETLELEIELGHNEIYYFLLID
VNDLSSYNESFGYLAGDKVLIEISNLLKIYFPNAYISRHYGQHFIVVIKKSNEEELLKLI
TSLINEISNNEKISAKRPITCCIGVSKGYLTNTLDIDEQIKLATKKLQISKQRGTGSCTL
>A0A8F6HBU0|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas indicatrix|TrEMBL
MTDQPDPRPAPGTAIGPPARVRAVVDDGRGDRVVLQGGGSVALQQLFAGADAPEPLLAAF
ANGMATLPGELGDMGDRLQSAQASADWPRYGRAMRQLIDKYIRTIDQHSPDGQPDSLRLS
EQLRLLLGGAVVALLQHDPDLREQAQALAVRLRQWQPGAALEPIEQGARELGHQIGVRAE
SWQEQQALLLELFALLLENVSELLDDRSWLQGQIAAVRQLLAGPLEAESVERTRAELREV
IYKQGLLRQGIDDSKAAMRSLMGEFIERMDGMAASTGEYHDRIGSYALQLREARSIADLN
HLLQEVMQDTGKVQQQAAQARDHLASARQEVERAEQRINQLEQDLRAAGDLARIDPLTQA
LNRRGLDELLQRELARAARNHSPLGLAVIDLDDFHQTNDEHGHAGGDALLQHLVAVCRLL
LRATDGIARLGGDEFVLVLPETPGADSMATVQRLQRSLAHRVLTLQERRIPVHFSAGLAQ
WQPGDDADTLLRRADDALYAAKRQGKNRVHAG
>A0A1T4ZDL4|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MVFGDLLLVSQLTSEQTLNQIMTLTQKIHQQLELGEVLDVTVKGIRAILGCDRAVVYRFL
PDGDGVVAEESVSPEGIPILGQLIYDPCFQAKWVDLYRRGQISSIEDVETKPLQACYKEL
LQRLQIRANLVVPILLLRSPSPQTSPTLPELWGLLIVHQCQSSRQWTTLDIKFMQHMAMQ
LGIAIQYREADHHLRQLYQQKSQRISLPIQEINARPDCQCSHLDDEYLTEKSNNAISILE
LNGLDRLQTPVWIFDIENLQMWWANPAALHIWNATDREELIQRNFQDISEATRIRLNAYL
QQFKYKKNITETWTFYPQGKPISVRCTCSGIQIETGRIAMLVEGITEVANQSSPETLRAI
EVLNHTTVMISLYTLEGVPLMQNPSALECYGDTLYPNLNHDNAFARHFVDPKIGETAIVT
AQSGAIFSIETQVYTLNGIRWHGLDVRCTRDPVTGNAMLLVNEKDITEQQTALIEHLHTE
QELRWKEALLRSMTDTSNLAFFVVDNQTDNILYFNHLFCKIWGIEHLEIQMLAGVLKNKD
IIPDCIPLIADVPAFTESCKPLQSQDNRAVIEDTIAFSDGRTIRRFSSQIRDQDDHYFGR
LYIFEDISDRQQVEINLKESEERYRSVIAAMAEGIVLQQVDGQITACNQSAEDILGLTTD
QMMGLTSIDPQWRAIQEDGSNFPGENHPAMVTLQTGKPQFNVIMGVYKPDKNLTWISINS
QPLFHPDSPQPYAVVASFTNITARKQVEETLKQQAEGERMIYTITQRIRQSLDLDEILQT
TTAEVRQFLQTDRVIIYRFNSDWGGMVVKESVSPGTKAILKMEITDSYFVENQGQYYWKN
TIKATPDIYTAGLTPCHLELLELLQVRAKLVVPIILQTQGLWGLLVVHDCTQPREWQTLE
IELTQQLAIQLAIAIHQSELHQQLQLANQQLQNLAMVDQLTQIANRRCFDDILNQEWHHL
IREQRPLSLLLCDIDYFKQYNDTYGHSQGDTCLQRVAQALQQGVQRSIDLVARYGGEEFV
VILPHTDREGALQVAQKIQDVLEQFNLPHRSSNVADRVTMSIGICTLIPTVERFPLDLIN
AADHALYQAKTQGRNRAVVSIL
>A0A8B6L090|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MSSIKNKSAEQIKNQTNLPKLPTLGRVLGRIHLIVALVSVATAGIFLTVVALFALRVYAE
HNLHLIARSISYTTEAAVVFGDTVVANEALSMIATNEEVAEAKIMDVNGRVVAQWTLPDD
GPMHQMEQSVARWALPEPVVLPIVHSGNEIGRIVIVGHGGSLLRFLLQGLAGLFVCLILS
TLVAIFLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAYFEGRLSRTLSDCKTNEHVAVLFLDGDRF
KEINDNYGHAAGDAVLTTIADRLRALLRESDLVARLGGDEFAILLAPIYNTDDVLIIANN
IIKSMTQPITLPDGSEIISSLSIGVAIYPDHAQTPDELLQRADEAMYQAKKGFRPCEQCT
AYQSDYIYSENKYPESTHTKI
>A0A8F7MRP2|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCAASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSKAILVDGRQKPFASWHNERLVRQDKISDVIS
KWLFPDPTVQPIWHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFALDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVHSSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAILLRDVHSETEVQALCRALSEQFIQPFNL
HNGHTTSLSLSIGYALTWEHASAENLQELADQNMYRMKHQRLQQTQK
>A0A087AHX5|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium choerinum|TrEMBL
MNGMNASKGTEAKIAVVDDEPSIRELLVASLHFAGYEVETAASGSEAIEVIERTKPDLII
LDVMLPDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVV
ARIRAILRRTREHVEDDPIIRVGDLEINEDSHDVTRAGQQIDLSPTEYKLLRYLMDNEGR
VLSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDDLEVTDEDGTKHKVQPLIETKRGIG
YMIRVPRS
>A0A1V5FVG0|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MSLTIPNRYASSADLPWFHWRGVALCRLQVALAMFTCLWVVSGLAAEARPLRDYPRVAWT
ARDGLPHQHINALAQTPDGALWVGTFEGLVRFNGANFTVMRPSNTPVLPDASIIGLSRAQ
DGSLLVVTSGRGIARWRAGQWLPIPEGINSPKDRVDGAWVDALGQLWVSLRDGGLWRVDA
NGTKRPIKDQPSSPVFAMQDDASGTMWIAGAFGLRRIEGDQVQSLAPDSGFPAVSVRALH
RTPGDGRLVVVTALGVFVERAGRFLPLARELVGINARDLDFGPQGEVIVATTDQGVLRLS
PRGELQRFAAEDGLLGTRVNAVLTDRDGDLWIGTGNGLQRLADLPVSMVSTHHGLRNPTI
RTLLSRPDGSVLAGGTGGLYRIRDGVAEPVLLEGVASVGTILSLIPSADGEVWVGSDLGV
VWKGDAVMRRHAVTDALPGGFEARTLAEDERGHLWLGGNLGVARWDGEQLLHFSEATGLR
RDYVLRLQSAREGGVWIGFNDGLARYANGAFSAVDVSGENAAREVFSILEDVDGTLWLAT
DRGLGRHRAGRTQHVDVRHGLPESKFFEVVDDARGNFWLTSNSGMTLVPRENAEAVLDGR
GNTLGNVTLNEAFGMAVSQCNGAAGQAGIIHDGEIWAATSAGIAHVSADRAMRFVSLPRG
VMIESMRVNGEVVPHDVNPMLPADTQRVEFDVVSPTFRAPDSLYYRHRLTGFDADWVIGD
RIGSRVQYTNLAPGEYRFEAQASADFLHWSGDNQAVVFQIAAHWWQRIEFVVLVVGGSLL
VLFVGYRLRIRNLQLRERALAMLVAERTAELQSTNSRLRMLNQREAERSADFQQQAMTDA
LTGLPNRRAFEHRLGLLLQDRVPLVLGLLDVDHFKRINDQYSHGAGDEVLTALGLHLRER
LSSTGSQRRGDPFVARWGGEEFAILWPHAALADARDVADRLRESVAQRAWPREGGAFRLT
VSLGLAERWEDESADAFVHRADAQLYAAKHAGRNRVEASVDG
>A0A2S8DPV6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVGLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1S9IWK0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMFALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTIMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A1V5MDA7|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin425|TrEMBL
MANEPGAEVKPVEPLFTRVISDLRKSRPQLAEALQANSAVLERVRDYEKQTALVIQQVSL
AAARGEDIEKLALLDPVTELYNHRAFIKELKAELARAKRYKHPASLIMVSIDSFDDLFRQ
YGQLTCDALLKIVSNALRGALREVDVACKYSEANYAVILPQTNSAGAALVGERVRQRIGN
QAIVHNWHNFSVTASVGVATFPEHASEYDLLIACAIEALDTALVRGGDRVVSV
>A0A823BB64|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDLGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A8E2TDL4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MYMHVDINGAYAAFECAMDPKLAKSPLIIASNNDATIIAMNRLAKNTGLKRGMPIFKCRD
LIEQHHIAVRSSNFTLYEDYSNRFHETLEGFAEDTDRYSVDESFMLLKNMDKIVDFEEYG
CLIRRTLLHNLSLTCGIGVSTTKTLAKLCTYASKRWAATGGVVVLTDPFRIKKLLSLIST
REIWGIGRKISERLTAYGIITACDFYDSDVRFLRKAFGVEMERTWRELHGESCFRLHESP
PVRQQIIVSRSFGQRLNTFSKMHEAVSFFTGRAAEQLRNDGSWTRQITVFIQSSPFARAE
ARYSSCGIEPLTATQDTRDLVSAAGAILTRIYKPGIDYAKAGVMLSSMTDGTEQLSLFDE
RPARRGSEALMKVMDRFNKEHRGSLFLACEGIHQDFRGKQAMLSPRYTTRWNELLVVKA
>A0A5C6FJK9|diguanylate cyclase|EC 2.7.7.65|Rubripirellula tenax|TrEMBL
MNARHQNCETIAILSATDIGKQRWVDLRSKLQLMVDRDPELMSIGIRSEFGTLRLDTGHH
EDMWSPDAQDIVHVDKVKIPITISGRSWGRVEYCYKSPHDGTFDRAINNPTVRLLSFYIV
AGMLAFTIFVVRMMGVFNNTQVVPDRVRQALDTLAEGLLVLDGTGRIVLANQAFADIVGI
DSDSLTHRRASELDWVEDDVSETGYPWMLAIETCELQSERMLRITLADGSQRIFSVNAAP
LGKDRTQRGALATFRDVTHVEEHRAELERMLSLLRSSRDEIQRKNRALEILATQDSLTGC
LNRRAFFEKFESFWTQSETDGQAMSCIMVDVDHFKSVNDTYGHHAGDDVLRVVAQTIRSL
QEEHGVVCRYGGEEFCVLLPSFDIEAALAEAERIRIAISEIRLEDPEELRLTASLGVSEL
RFKSSNPQELVNQADACLYVAKREGRNRSIVYNASYALIQDTEKILDEAKHDRVDIPFQA
VIALVSALSYRDAETAEHSRRVADLCSRAGEDVFDPAERYILEIAGLLHDIGKIGIPDDI
LLKPGKLTPEEWEIMGRHDRIGVEIIASSFDCPKLTDIMANHHAFYGGKARDPDLPVGED
IPVGARLLAIADSYDAMVSDRVYRKGRSHDEAIVELRRCAGTQFDPNLVELFIRKIDSTR
ATFATGAIALRKQNAITIGARVQELVGAAAAQDWPKLQSHASHIIQLADDFDLEAISKAA
ATIEESAKSEDRAWLIVLRQTHDLVDMCRAAQSDFLKRSLERDAEQINSQAK
>A0A3D1C4V6|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A378ADW4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAKNAQLLRSSLHDPLTGLANRAAFRNALA
ELMQNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLMEVASRLMTFAGKRHLAWRLGG
DEFAVLLRECARKQKCRPCARR
>A0A330SN91|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLIIIAVAAGCALVSPPVGTRHEILNNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNCVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHAL
AQSILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
STGAAG
>A0A1V5R6I0|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MNDTYGHEAGDRVLMQFSALLRQSVRQDDVVLRLGGEEFLIVLKNTDPAYLTLLAAKILD
RVRSFDFDLGEGSTLRKTCSIGLVPFPLFPDKPDLLSFEQGIQVADLALYHAKHHGRDQA
VALFAGPNGPAQDEDVQRLVTDLGAALDQGFLRMG
>A0A486U9E3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPKTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDKARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A486UC58|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKVLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNR
VSRMPFDSSERRRSRDGAA
>A0A5C6ECF7|diguanylate cyclase|EC 2.7.7.65|Rubripirellula tenax|TrEMBL
MIILPGQGKTEALEKIERLRQGLESDIFLRKENINLQITASIGLATYPEDAKDKRELLAA
ADQCLFRSKAAGKNRVTVYKADGQ
>A0A483KHU9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDALRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A486UDL3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLKEMRNGIYSTCPETQLQHYLRYLDTMTEIFEVWTLQTGKGLQSVYCKTTLVDTDDSG
TLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTVPMLLIDPSKDGRIVDANIA
ALRFYHYSDEEMRNKHTWQINTLGRDVIPIMNNIANMPGGHKPLNFTHILADGTLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFYRLVEAPSFIAQ
GFCLLLIDIDHFKSINDIHGHQKGDEVLLVISRILETSVDREDKIYRWGGEEFLLFLPHS
PIARALILAEGIRQGVSEYQTLSVTVSIGVAEHHDGEAIDQLFSRVDKALYVAKNGGRNR
VSRLPFENVELLHSRGGAA
>A0A862ZHY9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145|TrEMBL
MDNDNSLHKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDTFSNFIS
RWLFPAPVIQPIRHNGETIGEVQLTARDSSISHFIWFSLAVLTACILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNSADARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDL
HNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8J7WV91|diguanylate cyclase|EC 2.7.7.65|Desulfovermiculus sp|TrEMBL
EDEGRFVSSNPAWAKMCGYASPQELIESVTDIATQIYYDLGGRESFQQMLEADGEMIDYE
FRLRRADGSFLWVAETVRAMKNSEGKIIAYQGFATDISKRKQAQEMASKTKDRLDFALQA
ANIALWDWNMQTGELVITEQWAEMVGYTLDELEPVSIKTWEDFCHPDDFMLFTERLQEYL
DGRSSIYECEVRLRHKAGYWVWVLDRGQVVDWDEQDRPLRISGTHTDITKLKQYEEQLTY
LSLHDSLTGLYNRTYLENELDRLAKSRDYPITVICMDVDGLKLINDTLGHHHGDKQLQAC
AKILLKSFRASDILARIGGDEFAAIMPRTDQKAAERMQRRIQSSIENFNQQPGNHIPLSL
SIGLACAHSSNVDLAEIMKQADDRMYQNKLNPELKVRSRIMKSLMASLEERDFLYLGHAR
RLEKICLHLGEKVSLSSHQAAGLALLARVHDLGKVAIPEHILFKPEPLTTEEWQIMRQHP
EKGRQIALATSELAEIADLILKHHERWDGRGYPLGLAGEDIPIECRILAIADAFEVMTTD
RPYRKAVPVDRALEEIRKGAHRQFDPHLVKAFIAIGVRF
>A0A8F2J9X6|diguanylate cyclase|EC 2.7.7.65|Eubacterium sp. MSJ-33|TrEMBL
MFHYFLQLNFSTILISFFMLIFVNVNPVFQRKVIRLFSIAISSVLCLVIVDSIEYWCATL
PYPTMLRVAVSIIGYALRPINICFVIILSCGNRVSQKFKKFIALPGILNTLIASTALFSG
VCFSYSDKNEFVRGPLGYSAFAASGFYLILLVILTNKLYKTEHTYESLIAIFIAVTNTIA
VILEAFFHYDGLINTTGAVSIAFYYMYLTTQQFKRDPLTRALNRRYFYLDADHLMESKCL
TAVISIDLNDLKRLNDENGHAAGDTALCTIVACIQNILPRGCHLYRTGGDEFMILCSRVS
KDDVPVLIDHIRRELSKTLYCCAIGFATPDADEDFEHICSIADAAMYANKKQLKGEDTIR
>A0A5B9PDC5|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MRTTEMPRRILTRPNKQAPTTSMSAQDVAATKRLPSLPGVAQRMLEIAQQDEPSYRELSE
AIRADAVISGRVLKTVNSALFALRPKVESIEDAIPRLGISTLRTLMLSFHLSSWKASSPD
TQNAFRSIWRSCLTQAVIAELLAEKAELESSVCFTGGLIQDIGILAMVTELGEDYISNVL
YSSSHFHIADREKEQFGFTHVDVTGEILKRWNMGHAFIDATRQHHELDGKVESSEATRFA
AVLQSASLGASILATRASSSAVEEAVTQWLRSLNSNFGLNPLDAREVISEIEERVTEYSV
VFNFDISNGDTVEQVVGLAKELLQEIALESQLAMISVQQSANSKAKADDEIIYRDFLCGL
YNRRFLDEVMGTHLDAWVSKRKPVAMLYVDVDDFKLINDAFGHRTGDLAIKHVAKWLTDC
TRDTDFVFRIGGDEFLVIMQIKEKYYETVSRRLAADLPDLDCPDAGAIPMSLSVGGVIYQ
PKHGDEFDMQSLIDQADRQMYHSKKSGGNRASLV
>A0A1Z3HLI5|diguanylate cyclase|EC 2.7.7.65|Halomicronema hongdechloris C2206|TrEMBL
MILVIEDEAPIRDIISEMLEDVGFKVLEADTGAAGIELAQSHPPDLVLCDIMMPELDGYE
VLHQLRSQLLTALTPFIFLTAKSDRRDMRRGMLLGADDYITKPFTRHDLLEAVRTRLDRH
SIMRQVYTSVGANPANPAAAPSPPELSHRLRQLQTALANDEFELFYQPQATLADDQLLGV
EALIRWRSPSQGLIPPAEFIPLAERSGFIIELGEWVIRAACQQIKQWQALGLPPLSVCVN
LSSLQFARPDLISRINNILAEIGIAPKYLGIELTESVLVQNVDTTMAHLQALRRLGMLIS
IDDFGTGYASLGYLQHFPFDILKIDHCFVQHVHTNPTNGAITTAMIQMAHSLGLMVVAEG
VETTDELAYLKAQGCDAIQGYLLSQPLPASQFIQWLRRRQRP
>A0A3M2RBW0|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MHMLNHPDLGKAMTLSRSGLRDNHRRSLARFLLWVTGLSLMVFATLQLFSGYPWVSAVEF
VFGGLAFVGVARINHTPHFERWVYGYLFTLFSFFIVIMLLPDASMAAFVWVLMMPVLAYL
LLGRREGLLLSVPFMLLGCAVYVAFLSGIEGLSTADFVIDFLNMVLCSSLMQVFMYMYEA
RREEAELRLIEVAQTDALTGLANRGSFQFTLTRTIAESERSKAAFALVMMDIDHFKMIND
THGHEAGDYVLQEIGKCLQERLRVTDFVGRLGGEEFGLILRDVQPEAAYELIEELRRRIA
SRKLRLGDSDMAVTASFGMAHWPEDGRQADNLFSVADQHLYRVKRAGRNQVASSFNAQAS
QAKDAAAGGED
>Q32GJ1|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MSVKLRLPHCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFT
VSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A6N3S5Y2|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis STO1-CHOC-0019|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVTRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A4U9HJZ1|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNDENFYSKVYAREGIIHARTADEHHRSGIRLARRLRWPRAVGLAILFIPIASVLVSQPV
NGVWWLLLVGWAFVWPHLAWQIAARSSDPHSSEMFNLRVDAIMAGVWIGVMGVNAMPSAA
LVMMISMNLIGVGGIRLYGPGVIMTALAALIALQLTHVTPDYVSTPLEIGLALPVIVCYP
MLFAWMSFQTTRRLVEHKRRLELMSTLDGMTGVFNRRHWEVLLRTEYENYRRYHRSATLL
LIDIDHFKNINDSWGHDVGDLAIVAVTRQLQLTLRASDMIGRFGGDEFAVIMSGTTAESA
IAAMSRVHERLADLHLPGMPQVKISISVGVAPLTTSMVHYQEWLKAADIALYKAKNAGRN
RTEVAA
>A0A6B8N4C9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MLGFQMSVKLFSSQASLEQNVLKITSFFLAITGTGFTIVNFFFWDLPKFGVIDSIYTAIC
IYVYLRIEFGHYRPWHSALLISGLTALLIYSMAVADGYSVLVFWAFCFPALYHIFFNRYI
ASAITFAFYLVAISILASYPPLINSTPYTLINFTIPYFLIWAISFVHEDMQTKIKGKLSD
AALLDPLTGAKNRLALEADTSDNPDLVHNHYLVHFDLDHFKRVNDNYGHAAGDTVLKMVA
KIVGQQVRQDAFYRVGGEEFCTIFSAPDKESAFSIANALREKLSQTPISIGDQTLQVTLS
GGLCELVVEEGTVRIDETMKITDAALYQAKAQGRNQVIAI
>A0A4U9HJL4|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MTGEPDITCYHLPDACADHSLCVPLIAQGETIGLLSFQNVTRERAPSRAYLELMAEALGL
ALANQRLRDALLEKALFDPLTNLRNRHHLDDALRTQLGQAQHTGQPVSCLMIDIDHFKAI
NDKFGHDAGDLVIKSVATVVQRAVGDKGMPFRYGGEEFLILLPGADDAAAFACASEIQTN
VRSLALRYELTEIGTVDVSIGIASYPQHAQSDNLLRAADVALYRAKELGAQGLSVSGCLR
RSEGLSLPPLLP
>A0A6N2TL66|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MFELEDLGRIFSGQSDLCRIFDNFRLVDPQNGLSYRLDQGKLVLLACHGDPTEGLARQSQ
LQRRQLAKVELRDQKAKLLIAVPITCLCQPMVLELEKEIAGPGGDFQAVCSNCGNIPDIL
LELGNLASTDSFTGLYNKNTLELRLRRNLQEARDTGRSLCAAMVDIDNFKQINDLYGHTF
GDEVILQIVALLRRHTDGGENWSARFGGDEFLTIFPGEDLSSVKRRCDSLEQAIVLFPFR
RGDQPVSVSVSIGTAAFDPQTDTLSQFLDRVDRAMYQKKKQKKAVQL
>A0A1C3JQD5|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MLSIIRQHSHKAFFVFTAAFWVTSVLIVQFYAELSTNRITQEEQQNLRREAALIRSKIES
AIYEDVYIAGSLATVLRVSTSTVIDNWDSVASDLIQKSTHIRNIGIAPNNVISLVYPLEG
NEAAIGLDFRSAPEQYAAVMKAKESGDVYLDGPIELVQGGQALIARYPIFLDYPINQKYW
GSTSIVLNFADILQESNIRDLKNANFAIQRTTVGGVVDVFLGSEEVFESPDELLPVFLPN
NQWLIAVKSTAGLSDLAKLERNITQFFGYTGALILYISVFLLYRAYQLAHKASLKDELTH
LPNRRYLFNQLEQRMRPSKRKTGFALLNIDLNEFKQINDQFGHEAGDALLKHIAQLTNNI
LKGTDFIARVGGDEFLIVLDSSYTELAANERAKALKQHIENRPLHWKGSAITPSISIGVV
VYYPDIPTTQEELLHTADHNMYIQKEAHKNNSQIPHYLQGHII
>A0A1C3JVY8|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MDPTQDKVIESLLKAVSRTSMLAEGSDPELDATLQNIRTNLSKSQSPEVLQKTLQTLEPL
VLRYDEQRLARAQTFRAQLLELIDSIDNLPDTQMSTKAKKQLEADIRKHWQSVSSWPELL
AQSIQLVTNTLKQPPRDTKNASLLGRFFRRKSDHNLAPKSDSEIMSHVSHTLAALLANIT
LPDMYRDQLMDIKNALTGSKDINHLPALLDEVINLIMVAVGKTQEDLTLYLSQLNEQLAS
INASILANYKAQRSMSSTRKDLGETFQKHVDSTQTEVRNATDLNDLKSLIDERMQTITEA
MSQFQDKMQNQEKHAAQSITQLKNKVSRMEQDATELRTNMQQKIAQALSDALTGLPNRAA
YQEAIFPLLTSAAQVKQPLCVAVCDVDHFKRINDTWGHLAGDKVLRIIPRQMQNALNKES
LIFRYGGEEFIIIFPMTSIDNAYQYCEKVRQAVENTPFNMNGDPVSVSISIGIAQFDGKE
SHDELFGRADKNLYKAKEEGRNKVIHDN
>A0A1V5GCU3|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MADEIFGERLYHIGKAVVDGSFHTQRADEAFFSYFGNDVTYSIRRTIDDADFPRIEQCLK
EAENDGNACTVIRMKGVSGMLRWVLASVSLLEITGDSPVFSIRFSDIMSLEAQGYLRQRR
LSDYRSFLGLSGDLAFEYSFGTKHIKIFMFDLCREVVLVDEELDAWQKNAIDKGYVLSRY
LEPFGSLCDDIRNGTYRFDHEFESSLLNEGRIKEMYLFRGITRYDSPDSRKVIGVISAIS
SQHRGKDINMALEANRDSLSGLLNKRAVTSYAEEMISAKPAYTVKLVLLYIDNFSEMTGS
LGHSFGDEIIYRVAQIIKREIGEHGFAGRISAEGYLIVLEDIRDEEELRGILRAIRSNTE
FAFADKENELRITCSMGIAGYPDDSSDYEELFMQAEKALGIAQEKGQNRYVIYDIGKHGA
VAKDMGSRSAFLSNRGESSEKLDFIGQLAENLVMGRIPDLSVLLEQLRVGFDIDDICVFA
GADMGLILSCGNAPCKDASYLFENNYTDRFSGDGVFVIDNVNELEGRDDNAFAKLMEQNI
GGAVQYLMTENNMVKGVISFCYIGRFKKWAVTDINYCAIVGRTITALLKKQAYI
>A0A3P4B409|diguanylate cyclase|EC 2.7.7.65|Pigmentiphaga humi|TrEMBL
MKVSSPASLPVADDRPRTAAGRRKPVPIRVGLLAVVLASTLPATLVAIRAVYDSYEVLRN
RVYESTIVLARTIAADIDRELEGIGAGLRVLASSPDLARGDLNSFYKRALDASKLQGVEG
YVLADLQGNAILDTHQRYLPSRSIKRTMPPLPEHRDNLTTVMRLPADPEHGAAPVAIAVP
VFLDGEQRYTLYADLHNGRLGEIMRRHAISSGWIVAMADTDSVIVGRNRDEGLYLGQQAT
PAIADIMHTRREGTLSRGRTKDGIPVLTGFTHINTAPWAVIVGAPAEALTAAVQRDILRV
SIIGLLTVLLGLGLAYLFARRIEKSVGSLLEPALALGSSRYAEAAGPRFKETAAVADALE
RAAQSLAHARQLAYYDPLTELRNRNLFEELARLAIAGAPRSGASLALLAVDLDHFKAVND
THGHAAGDTVLRQAAARMAGAIRKSDVAARYGGDEFMILLDGAGPAAAKTVADMLVAALG
APYPGIAPAVSASIGIAVFPQSGTTFEELVAKADAALYAAKAQGRSRAFCDPAAMQSGAA
LAGRPA
>A0A7W8URH8|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. HC6.4b|TrEMBL
MDTSKPPQNAATLHPADDANAQAHALVAEDAPSLASDDALARILADPPAAECPIMVLLVD
DQAVIAEGVREALADEPGIDFRYCASWEDAVRCAEETRATVILQDLVMPGTDGLTLVRQY
RLNAATRDIPIVVLSTNEEPLVKSAAFAAGSSDYLVKLPDRIELIARIRYHSCSYLHLLQ
RDEAYRALRQSQRQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWHRGTRDKTGLGL
LMIDVDHFKAYNDTYGHVAGDEVLKSVAHTIEACLGHSLDLAARFGGEEFAVVVPDTSAG
GLRLLAEKIRIAVEDRAITHAGSAEGVVTISIGAAMVVPSAAEPVTTLIEAAGVGLYRAK
HDGKNQVAVSG
>A0A379JMT0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSSTTRRGTQRSLQSLLLKRFAMAFATYAMMALVCWFAVFNGLFLGSISTAAWLTLGVFG
SQLVFLWLFLSGRNLRCEDPSLTEAQVLVALAWQPPLLALFDSARGVMMVFYVLILLFGV
FQLPPRVFVRCAAFAFFGFTAMVLIEAYRMQLVDPSLAWLQVWVLFILLVWLCLFSSYVQ
AMRKRMHQRRFALQAHQDTLRGMMRQLENLVATDELTGLFNRRHFLRLATRELEHLEHGR
HHGLALIDLDHFKRINDAHGHAAGDRVLQTFAAVARACLRDGDIIARYGGEEFVLLLPNT
DADQFTACCERLREAFARAEPVGVKVDNLSLSAGMTLLVAGDDLDEALQRADQALYKAKR
GGRNRCDASWENAGA
>A0A5C5XE95|diguanylate cyclase|EC 2.7.7.65|Rubinisphaera italica|TrEMBL
MTNIWQATVSSKNNTSVPKSNGPGKLLQIHPVQINTGLIDIPESGLKIGRGNTAELILHD
DSISREHASISFQNGTCYLQDLGSTNGTFLNGVDVEKADIRPGDRISVGSYIFKLLSNDE
TEAQYYEAVYDMMTQDGLTRATNKRAFLDILKRETLRSINTNRPLSLIMFDIDHFKSIND
TYGHLAGDQVLREVSQRIRSVIESHVTFARYGGEEFALLIPELNIEQIATIAERCRAVIS
ETKFDCESDTITVSISLGVSNMQSLSQDTLQPDTDLIAIADAKLYRSKNEGRNRVTI
>D8ECU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 119-7|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A518N210|diguanylate cyclase|EC 2.7.7.65|Luteimonas granuli|TrEMBL
MSPPRSQTQTRAETQVQTRPAPRPLPPPDDPRLLEDWRRRLDAVPEEVRTLLAEVVAAGG
PALADHFYGDMLEDPRASRYLNVDQVRERLKPSLQRWLAELLSAGADGVEALHATQEHVG
HVHARIGIPVDLVSRGARRLKDDLHAGIRQRAGSEGLALEAILCADGLVDIALESMTRAY
SRSRDAAGQVDGAFRLFSLIQNIGTERERQRALLLTWENALLYALTSDAPGPAAPLQLSR
SEFGLWFLHKGMASFGDTAETREVNLIAARMDSTLRARLPEATTAAARRELLDELRAGAD
AIRSLVTMMFDGIGDLESGRDALTRLLNRRFLPTILRREIALQANTGRQFAVLMLDLDHF
KSINDTHGHEAGDRALKHVAALLVENTRGSDYLFRYGGEEFVVVLGSVSLDDAIAIAEGL
RNAIASSPVVLADGTSLPLTASIGVAVQDGHPDYERVLARADAAMYQAKRGGRDRVVVDD
GGLPDPPGVRALRG
>A0A192C6U5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MAMIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWI
DHLGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALT
DYKIYLLTVRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGH
LIGDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKATNDEEACRAGVRICQLVDNHAI
THSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1V5U549|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin248|TrEMBL
MPNRDKRENAMLAVMLAILVAATFYSMFLYQHASVERIRGKTNETLSAEVRENKSVFLAA
LDWQYRSLEAVAAGLSAAGVENAQAELERLGQFVGGAAFFEIYLADAAGDSLAGDEGAIN
ISDRLYFRQSLAGERGLEAVASRIDGAPRFALSVPVKSGDAVELVLYALFSEDAFTGVLQ
TKASYDGSRTLILSCAGEKVYGGSGLMQGSLLVDLERAGEAGALAVLQNDFASGASGIVN
YTLYDTETYLAYAPLGVNGWMICTSAPAARVNEEISQTVKSGYLIVAAILILAAAFVLLF
AYVVRQNTKRLIADQTRLNEIGARYRMALENTSVAVWDFDPVRRVLSIDARSARLLGVRE
GSHEDVPESLIASGFVHPDSAQDLRGLHARLAAGEKSLEEVFLLRAQNGEGWRYERVRYT
NLFDEKGRAYLAIGMGEDVSAEYAEKRRLDELSLAAQSDSMTGLLNHDATFSHIRRYLRA
EGATGMHALFVIDIDDFKRVNDTLGHQRGDAAIEQIAAAIRATFRATDVVGRVGGDEFMV
LLKNAPDLSFIERKARELRDALHIPCGAGDCLPVSASAGVALYRGDGRPFEQIYAEADEA
LYRAKSEGKDRFFIGARP
>A0A655W8C6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNLNNFSLRWLTTLNALAVVLGFLMFYLTFKYFWSHDREVAQVLQLQQAELQRVETLLSL
ERKAMGASLADYAAWDEMADFIAKPTLEFTQSNIGEHAFSSQFLDGVFIYDPEGNLVWGK
KYDAATGQSSSYEHLLPDFSRILQQATRLSVNEISTSVRYMVVEDEPYLAATARVCDSDG
KGCNKGFLIFIKKVRAQFANVVEQATGVDIEVLTCKNDAPLPQDEVDVSYIKQLDYSGNS
SVLFKINHHIKHPAFIRTEEILALLFFSLVMYLVNLWVVIALIKPITTASQVLQQFKTSG
GKMPDASTFISSEMKEFATTINRIVGQLEDSQQVLRWQSEHDPLTRISNRRHLEKQLKSY
LSDRPQAYLVLFLVDIDFFKRFNDSFGHLAGDEALCSVADVLQSVEFHGEKIVARFGGEE
FCVVLASDCAFDAEQYAQQMRSKIEQLAIANPVDALCQYLTVSIGGVYAISPKMESYLSL
FHQADMALYHAKEHGRDRYVVRNFV
>A0A7Z1D505|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRVSAPF
NIH
>A0A656BGK8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A7L6JL65|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00524|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTIMHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A080N3W6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bombi DSM 19703|TrEMBL
MDSGLAQHTDPVTILVVEDEPDLATAIAQRIAAKGWRARVASDGASAVRAARTIKPDLVI
MDIMLPIMDGITATRHIVEERPVPVLMLTARDGEADKINGLNAGADDYMTKPFSPRELIA
RCEALLRRVKRASIIAQNNAHEQVLDFGSLVINPGERTVTLNGEPIHLTPTEFDLLVTLA
RKPKTVFKRDELLKSIWNWYDSSTTRTVDSHVKALRHKIGTARIRTTHGVGYAFIPPDDG
EDDSSWMHQTGGSRDGETAKEGGALPDSRTMPNGTIPSYDTPGF
>A0A0E1CH38|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30660/NJST258_1|TrEMBL
MLTNKRERARQQRAALWATRDNVQRHALSMSMPWLAFVNIAFALMIFFRNFIFTYFDKRL
LTHRAVIPYIEAALIAVIIISAILVIIALTPRLAQGRYTLNIITGLLLALSLCWSLSNYC
FIFFWTLPFAWPLLVILMTTGLTALYHHWPGITAFMLPLWVTALLAGIQLHYHTEIRFLI
LWAIFTAILLYGRRILQRWYDEAWDTHQENMQLIQRLESIANQDALTGTANRRALNAYLA
AIWQQKTPLALMMIDVDYFKRYNDRYGHQAGDECLSSVAQVLKMAVRAEGDLVARYGGEE
FVVVLPGVSLAHATAIAERIQQKIREAGLPHAASAVASEVTVSIGIVASDGTVPIETLIA
RADRALYQAKNKGRNQWSY
>K2KYT9|diguanylate cyclase|EC 2.7.7.65|Idiomarina xiamenensis 10-D-4|TrEMBL
MLAEHLQGLEQDWSSALRQVDQAVHDAVREKVRQAAPTLAASFYREMMAQADASVFLNND
IVHQRLSSSLQHWLQDLFQARDSDEDIKALIACQVNIGEVHGRIDIPVHLVQRGGRMLKR
TFSELYQAPFAEYQFFSQMVDIAIEVMSIAYHKNDQRNTRTEEAYRLFSITQNIGREKES
QRAALLDWENHLLYEQAVGNASSRHLLLAQSEFGLWFRHKGIHAFEGAPECDQVLQQISQ
IDTQLLPRLLRSEAGHSDRLSAIFDIRAALKTTLFCLDSLFQRSEELENGKDVLTRLLNR
KFLPAVMTKQLTMARQRNERFAVLAVDIDHFKSINDRYGHDNGDLVLQQFALLLANVTRS
GDYTFRLGGEEFLVLLVDVDETVCMTIAEKIRQQIANEVFRLQPEQSIKVTASIGVSLYA
GHPDYQYNLKCADQALYQAKQDGRDRVVMASGMMQEGEAPAV
>A0A378K857|diguanylate cyclase|EC 2.7.7.65|Legionella pneumophila|TrEMBL
MPSIVLPKLSGSYYISLYLTIVFSTLTLILGLSVIIGWHSGIVFLIQYYPNTVAIVYNTA
LCFIALSFSIFLFLNWHYKSAIILSLAVFILSGLALAQHVFSINLGIDEIFFHHYQSIEN
AYAGRMAANTAFCFLLIATALILMNFSGNQPINNSLAGALSLLVFCLAVLFISGYFSDIQ
QAYKWGNKTPMSINTGIGFLLLSLAMMSLYWHNNTIHQLNSSIAMPYLSSFCIMLTFSLL
SFEIFKKEKELNLSTNLSLTTFALGILFSILFGLIIRLWQLAKISTATAKYALSEVNATL
ESTADGILVVDRTGNVMNYNKRFLNMWYQKERFLKTINYHDIKLMINKQLINRREAIQRI
NKILKNPDYQQAFELKLKNNTYYHCYTQPLKLDDEIIGRVWSFRDITIPKRLEMELSHQS
THDTLTNLPNKVLAINILGYAMKTAVSSKKIIGVYLLDLDRFTQINDVFGHSKGDEIIKA
VSKRLIDCMPMNHVLGRLSGDQFIVIASINNSKEVVTGVTRLMSAFHEPVKMNGHSIKMS
CSVGISFYPKDGDTVDTLLSKADIALSRTKIEGRNSFQFYTQEMHSYTLEHILLESELRN
AVAKNEFVLYYQPILKLSTLSVIGFEALIRWNHPGKGLILPDKFISLAEEIGVIGEIGDW
VFVTVCKQIRAWQLQGFNNLKISINISPKQFKFRHFPKKVNELLSEFQVKPEFIELELTE
NILIDKSADIIDILSELKGMGIQISIDDFGTGYSCLSYLKDLPINVLKIDQIFVKDLKNN
QSNQTLIKAIIAMAKSFNLSLIAEGIQNKHELVFLQNLGCHYGQGYYFYHPMPPEKCTQL
LQ
>A0A0M2WR55|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MTDALPAAPPAALPEVLFSRLLEDALDAVIIIDEHCRIRYINGAMQALSGYASGELLGQT
LNGLLPDAVGAQHDNHVINYIRSSRTSSVLGKIREFAIRHRDTQMIPIEMKALDLGVVDG
IRYFGAFLLDVRERRELAAKNASLLAQLEQQALHDALTSLPNRRAYEAQAAQAMARAARS
GAALTVGVADLDHFKKINDRYGHAVGDAVLRTVAQALRDTGRITDVAARLGGEEFGLLFP
DASLQQAHVVAERIRAAVAAAITPLPDGGQLQVTISIGVASLTAGATLDAAMSDADKALY
AAKHQGRNKVVAAAAAE
>A0A447LR03|diguanylate cyclase|EC 2.7.7.65|Atlantibacter hermannii|TrEMBL
MSAETKQHPWRLKHPIKIVNICFLVVFLCSTLLTWREMVVLENGWTASQKNRIQNIAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAEFSRQRHSDAWQIRLDATRGLPIN
GVSDEHVRKNPLLNRDEQRLERELIAALEFGAILQLANPQQESQHRTFYTSRAGFFLSNA
QHPAADAIASRYHRLITRPYFHSHTQQNNPQRGVRWTRNKEVNREGDHVITASLPLDYQN
QWYGVLAMDFPQGTMNTFLNEAMFRRENGEILLLDNDFQVIASSAATSPAASGFTQRDRE
ILSGEMKQHSQGGMRIGSRYVSWAKLNFFDGMLVRSYSLKQSLSGEFGSILLVLGILWLL
FSLMLLGSWYVLRRMVRNMYRLQETLRWRVSYDSHTHLYSRGAFIERAKRIAARCQHQGL
PFSLIQIDLDYFKRINDTWGHQAGDQALIHAAGILRKALRGDDIAGRVGGEEFCVVLPNT
LLPEAAAIAERIRERLNSKEILARPNTTIRITASFGVSCAIPGGDYDFEHLQSIADRRLY
QAKQAGRNRVCSTG
>A0A636CUF3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Concord|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINGKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6S6ZRT4|diguanylate cyclase|EC 2.7.7.65|Achromobacter kerstersii|TrEMBL
MPVWSGGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFYSTLLADV
EAGPRLSHEIVATRLHNGMKYWLKGLLCVRDQGDIVALMATQKKVGEVHARVHIPIHLVM
AGARVLKNEISARLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRGARNDEAY
RLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQHKGGVLF
ESAPALRQITEAVTRLDDVVLPQLMMAEAQRQMSLPDQVRELQELVARIKHLLNGLFDMV
AEIESGSDPLTNVLNRRFLPSVIGREIAIASRQESRFSVLLLDIDHFKAINDAHGHSGGD
QVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGQEAALAAAEKLGNEIRRHDFTIPE
VGALRITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDQSVAA
>A0A735V5Y7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:z:1,5|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAVG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5E4R7T2|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MTILLGVLAAWAFARFAADQLVASRLARLLFEERSIASRLAHGTVHTVNQDLMLIRGIPR
VLAQIGQIQNAAAAVADHPLTSLSPKAARHALLANPQLKPVNALLSAAQQYFGADLVWLG
TADGVTIASSDADTASPLVGDNFGDRAYFNAAVLGGTGQQYVIGRKTGLPGIYFTAPVYH
DGRLVGVVVVKLGIRRLSHWVDTGASFVTDPNGVIVLANDPTFTGLAVPGARIFDMTPDE
RRHLYKREDFTVVPIEAYDLAPGTPAIFRHQSDGDTGKRTARLVRIRPDNQPFLMEAEVS
TDDDLVIYTMSEAPTLGSLSIERRRYAVLVFALLLSSAGALYLLVRYLRREKLQLTDTLA
KNAALEHEVKYDALTGALSRGHFLKRLYSEVSRTEATDMPACVILVDLDHFKQINDTWGH
ALGDTVLANFVHLCHESLREDDICGRLGGEEFAIILSGATEARAFEAAERLREAVRTSRI
AVDDRTLQFTISAGVAQWHPGDDANAWLRRADAALYLAKSHGRDRCARESDLRDLTQGGS
>A0A173TVK5|diguanylate cyclase|EC 2.7.7.65|Faecalibacterium prausnitzii|TrEMBL
MMGKLQMDREWTEQDLRAFVEGAQAAFETVLLDELPQDTGWQDEGLQVSYTLCNGRVSCV
LHRTVRADGKLWRITMSAPLAGNLLPEERMSARERELCREDLNHDFLSGVYNRRYLETVI
AAELDRWAAQGRKAAVALVSLDHGAQLRDTYGQPVMDQLICFVANQWKKYFDIPGSQIVC
RLTGTTFVVGCLDMDGGQLAEQMRNIYAEMPHECITSMGMMKRVPFTLSVAVAGLDELDS
AASCWQRLYAICDERLRGIQISGGDKIC
>A0A5E4UY38|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MLIKCLFPPPVIAMLTTSLLAITSLLSFMMLLIVGSLLRSRVAGVREWCLANLAVLVSLP
LFALRGVVPDFLSIPTANVALAGGLLLYYAGCARFLGRPPHWRVLAALLAGLCAVMVLWR
YGFDSPQVRVVVVSAFHASILLAIAVMILRNVPPRRPPYYYWLTAGLATAFALGHIVRGL
VFGLTPAPGPDLLAPTAFNAVMLVIGSVVMPAMTMGSVLMIHDAMLATAEEAANRDYLTG
ALSRKHFDLLARQEMARALSRSLPLSIVVIDLDHFKQINDTHGHAGGDTVLREFVKLVRD
SLREDDVFGRLGGEEFAILLPGTDTHGAIRIAERLRTQASRHLVAGPFGVCHYTLSGGVA
TWHEHESLEAFCARADRALYAAKISGRNLVLSDVLPSDETAPEAG
>A0A6N2WV25|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MARHNRKLSFTTPILVSFTGIILSFLLIAIFITFTQKNDFLEDYHGINRNFTHNLAVNYT
ESLLRENDYILGRAATYFSRNDHLNDTVNLDPEQGLKTIMQLQTLMPSVSSISLVDIEGH
YLRAPQVLNTERSTTFDVKSRPWFMDQAEASTFSNYTAPYIDYFTHHPTVTIYKPVISPE
GKMKGTIAFHLDLTSMGYALRQMVAPVQGEFYVVDRDGKVVLHPDTGALFKQYVSKKTMS
RMTSGEGHLYDPDTQDWYYYYSFTNPDWFVIYRVSDTTLVDLTRHETNIVVWGFALAAII
IALFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIESNKERELAYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFVLALVDIDNFKFINDTWGHLNGDIVLRNVAREGIQI
MQPAAVSVYRYGGEEFAVLFSGEQLNNAHTLLERWRIEVAQRSWREEGLHVTFSAGLGEW
NLEAQEQLIMRVDEALYKAKQEGKNRIIVANR
>A0A8H9YWS3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MFPKIMNDENFYNKGVTREEWQQDLSQDDHHRSGIRFARRVRLPRALGLAAMFFPIAGAM
VAHAPPGGWWLLLVGWAFIWPHLAWQLAYRSADPRSSEILNLKADAMVAGVWMGLMGVDL
LPTVALVMMIGMNLMGAGGVRLFGAGAMIAVITTLITLQLTGTTPAFTLTPLELWLSLPV
LVLYPLIFAWVSYQTAIRLAEHKRRLELMSTRDGMTGVFNRRHWEILLRNEYDICMRSHR
DAAILIIDIDHFKDINDTWGHDVGDEAIIAVTRQLQLTLRAGDLIGRFGGDEFAVVMSGT
PAESAIAAMSRVHERLAALTLPCAPQVRLRISVGVAPLTPEFGHYREWLKAADVALYKAK
NAGRNRTEVAA
>A0A3T2UY99|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKSEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A658Y317|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVS
DALVSEGNFLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTL
FTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNNYW
YGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALL
AQAMEHDTRGGIRMDSRYVSWERLDHFDGVLARVHTLSEGVRGDFGSISIALTLLWALFT
TMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPF
SVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGANL
TQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLA
KQAGRNRVFASDNA
>A0A1V8NTZ1|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEIVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A1H8IYI1|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MTLQFRFRPAAIVAHIKSATLGALTSAAGMTAVVCLLSLLVPERPFWVELTAVALISAAV
TFPLQFALHRRKKALRDLQKELQHALHHDPIIVTLCADAFATPVEHAIDRRRVSTAESPD
GVILVVRVGNFDEIGRRYGPQWADTLLQSIAWIVHSSVRHGDLVARVASDEVGIYLPNAT
MENVNKICERIRARVYETTFIAGQERQIPVTVRFGGTRVGDQSAFQALSEAANSAALAEE
EAGPLLFRELFS
>A0A0D8HTZ2|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MQAYPVRVGAAVDDGHSGSKATERPFSSAALHRVAPLLVDWYRRPDQFESFTRYLADKGL
TGASRTLVVSSLLLVIVVMFLTRFSPAGPTTHGERTANLVIIVLTALMAAILATRGRLER
SWSYVFVIYSEIGIAAALVLYSNPLAALAHSVMFSVIGGYIAFFHNARMQTLHLLWASVV
VIGVVARIAYIEKYTDVPSLIAMVLLVGAAIYAIPFACQFVFSILGTDALKAQHDPLSGL
LNRRGLADEVGLMLHRPFESSTNLVVAAVDINRFKTINDEYGHDVGDVVIEKVAARLTQS
AGPSALIARIGGDEFVLVDRCDDQEIDSLAESLRNITVTGPEHPVVELSVGIVAAAGPFG
SPDRAIAVYGTLLRSADQAMYTAKARQEHAVVVLRNLQ
>J3S6P4|diguanylate cyclase|EC 2.7.7.65|Acytostelium subglobosum|TrEMBL
MEILEDSVYRLFTHNQLDEEVSRPTTTIGTSKNNNRVTNTDQSMIFHMDLPHCINDSPIN
YRYYQATDHYPRPSTLLDNHNNNNYSQQDKLEIYLCPANNNLLYNNYNNNNNNNNSIEQP
IFDYTYRDLITLVIVIALILYNYSKRERKIIQFANTFKEILKLTPTITIIEICYDSRRRI
VKTSNPINTWQDRNVFASCSNQQHDDSSTTLAAYKYSIERFCKHLCINPDTLEQSIKSSD
SSRDIIIKGCSDKIYKFSGHFDAVTMSFRGAVVDISKERLEMKRLKYKITHDHLTGLQNR
YQLNHRIKKFCSASTSGLCAIYFLDINRFKLINDTHGHENGDKVLKHMSNILQNTQGPDS
LPIRLSGDEFLIVKRNVQSMENARAFIGESLAVVSSSPVELSNGKKISVTISYGGVVFKS
HHSNSVMPEEIIKLADEYMYHMKKHGLPLVKFHTRPNVLSASV
>A0A2Z5SS73|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MSGDILNDIVAACLELERKASSVFRMFAAHAGSDEARRFWETVADETHHHSAVYERLQER
GGRENLPIIIYKPAETLEELEMIGKSIDEQVERYTEAPSSEAACLLGFRLQLYLLHPAFA
SLCRLTRDATGEDLPDIGYGRYLRRFIDGIGSCGLATAETELLGEALFRLWNEARQLAAQ
SHFDALTGVMTRAGFFKTVGPLAYAAQRSGSNVGIMLIDLDYFKLVGDNYGHQTGDRILQ
LVAETITAHLRRSDVVGRYDGDEFVVYLSPVDPASLRTVAENLRRSIEEESARMVPVTAS
IGVAQGVLGTDVDRGLEELVRLADECLMQAKYTGKNKVVVK
>A0A2Z5SWU2|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MRILIADDDVTSRTMLTGLMKRWGYDVVEAIDGAQAWEELQKSDAPKLAVLDWVMPVMDG
VEVIRLVRARSAEHLPYILLLTAKNGTDDVIRGLDAGADDYVGKPFSLGELRARIQVGRR
TVELHSRLQETQEALNHQATHDPLTGVMNRRAIIDHLEKELSRVKRDGGRLSIGIVDIDH
FKRVNDRYGHQTGDEVLCGCVGVLGGLLRDYDLLGRLGGEEFLVVAPGTGDDCSHLYERL
RAAIASTKFTSRVKPVSVTISIGVAVSDGTTGLDDLLAAADGALYRAKRSGRDRVVQAES
S
>A0A0H3PJE0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7 (strain EC869)|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVGS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A518B9B8|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan216|TrEMBL
MSSRPPVPDSLEGGRSVPVDFDQLDKLVLPSLPQTAAALLHCAQDPTTGIEDLGKALELE
PAIATRIVWLANSAIFGSSGEVSSVEQAVTLLGVNTVRLAILGATTTMVFPKRAKDPLIG
RCWRRIFLTAIGCRLHAGIFGVDSQKAFLAGLTQDIAILLLADRYDEQYASILEEARRPE
QRQSLIELERATLGIDHATIGARLLEHWRFPSDLVDAVRTHHEVNVLSALAAGERTLPVL
MAYAEEFAECFLMQSEEGLVRIEKFAIVLEEADLISRDQFDRVVQKLEARALDLADLLDV
EMPVTGGFHEMLSRARLLAAPLADHSQLVDAQTGLLHRDGLIRRIEQEMALAKRKHWPFS
LLLIRLSSLNAYDEKGRIDESLELVQRTAHHLVHLLRTSDSVFRHSADTFCVVAGNTGLE
GAMRLIERIRPPLREIDSAGMGAAFGLLTVCPTSAVSNAVQLLRRTFELVDGAQQGDGLA
FEEC
>A0A0J6W0V4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MTLASFAGTRAVRALAVGVVIFTASVAGIDSRLPESIAVLWPANAILLAVLVRHRAARRH
LEVWSAAAVGYVAADLSQGTAATPAVVLAVANLAGVVVALLVFVRLDVADVRVATPSTVV
RLASGCVAGCAVGAVIGATVAVSYFGGTWPEGWLSWFACDLVNYACLLPVLLTVRRWRWT
SWTGLVGALRTVATSWTLLIALLVVAWLMRDSGSAVAFTMPALMACALGGRMFATALMVM
TSTVAMLALSVGVGASAAPAPVSTTTQIALALLALGPLLVAAATAERRRLLDEIRQATTR
DDLTGVLRRGEFAARAQELLAHGDSTGMPTAFLMMDLDHFKLLNDRRGHRAGDQALVEFS
AILRDVLGSQRDDPRGAIIGRVGGEEFAALLPGVSVERARALAEEIRRRQEDRARADFGA
DGSTVSIGVSGCTGRHTLDELMMSADASVYSAKRQGRNDVVVFADTVLRAVGD
>A0A6N3G2Z6|diguanylate cyclase|EC 2.7.7.65|Clostridium butyricum|TrEMBL
MKNNNYDKCENIFLDAINRIGCREYILIKERIYYYLSKLYEKSLDYENAYKCLKNSVKCK
NILKNDSQVSLKRLKEKDMIYAVQKYKSLYDKMERISNLGKTLTANLDVEKFTYIIYEEI
KKLVMLDTFAIGIYEKNKKELNYKIVFKNDKKLPGIVSKVEEGKSLGAYCICNKNDIIIN
NMAKEYSKYIYKVKINKKQLQEEAKSIISIPLLLDNEATGVMTVQSHKINAYTNEDLNEL
KILASYVAIAMRNLQLFNEAKHFAEYDVLTECFNRNKILSLGKKIYDESKENGYDLCVAM
VDVDNFKSINDNYGHGAGDHILKSVARIMKKNIGDNDYIGRYGGEEFIIIFNKKNIEQAS
DICENLRRRIEKSKYNIGDRSINATVSIGIFEIHDNISFSDGIKYADESLYVAKKTGKNK
IVKTS
>A0A238DNM2|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MQKTESDADLTDEGRRSTSQAEATLEALAHANVATELDLLLLSVDQESVLYPELLEFLLH
RAGLDAVWLGHRGPDGELVFDAVDGVGMAAYLAGVAIGFDGEVHEQGPTALAWTTGMPQI
VTEWATDPRTVAWRDAGEQAGWRGGAILPMQGIDGRRDLLAMYSRKPGFFEQVHNQRLVW
HLHAVLGLKLGRMRLMRQLREQGQSLQMLKAAIEASEAGMCVADAQAPDYPLVYVNPAFE
RITGYTAAQALGRNCRFLQGGERDQPALAEVRAALREGRSCSVELRNVRADGGVFWNEMS
LAPVRGEAGAITHVVGLMNDVSARHALEAENASTQGLYRALLAEEELVLSATDLSEMLQQ
ACERLSASDLFSAALVGRAGPQGDIDLLAQAGRTQISETWYRPKVAGEQAGQSLAARVWN
SKCLQFSNDYLNDPAFAMYREEMREAGVRSVAITPILRGGHRWALLGVVSDRVGVFTPQV
VELLERVAVLVGHGLDAFDLRRRLQQEHRHISWLAEHDPLTGLLNRRGLRLRLEEALSQV
DVQGGFIAVGILDFDDFKQINDNYGHAAGDGLLRTVAARLVEAVRSSDTVARLGGDEIAL
VLQGMATRDDLEPMLSRIRRAVDLPVALPGGERMVHVRASLGCTIYPDDTSEPDELLRHA
DQALYAIKQQSRSASAPFWRVYQPATDRDHFNHLRLVRDRFAEGGLRVHYQPVVDLTSGR
VTEVEALARLDDGNGKLMPPLDFIHQLGRDGLVALTGQVLRQAVTDAQQWQRDLGAELSI
AVNMDPGMLASGEALALVNDVVATASFSARRIVLEILEHSDFLSLATAQQALSELRAVGC
RIALDDVGSAYSSLLRMKELPIDIIKLDQGFIRGLAERPQDLRFVQSLTQLARGLGVDFV
AEGAETEDIVEALRALRVPQAQGYGIARPMPASDFGPWLQSWSQRMRPSEPGLLTRIADM
LVGLDVDLLLASRQSVQTPDLSISHPQEQCAICQWLQQSGLPHDSPLVLAHQELHAMFHD
WLEAGRNADSSMIQSALDHFLRTAGDHLRSLREAPRP
>A0A7W8ITE9|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus tepidamans|TrEMBL
MNKKLLLWLFIVITMILPFVLFIFFPYNAIWSLLLIPIVFVVVACQKWGVAISITFLLSV
LEYAFTFTYYGFSRTLFVELLIGTIINYSIFFTIVYFKIQYEKLLKKVQKLTVIDPLTGV
YNRRYFNLYIEKAIPLGERTGSPFHLILIDIDHFKKINDTYGHMFGDEVLKKVARLIKAN
VRKSDGVVRLGGEEFAILVSETTTEECQLLAERVRQAIESADFIYEGKKVHVTVSVGLAT
YKGTSVPKLIEQADQALYQAKANGRNQVVIFSHHY
>A0A136K533|diguanylate cyclase|EC 2.7.7.65|Nitrospira sp. OLB3|TrEMBL
MGILIVDDSADDRLLIQSILANAGYEETFVAESAAAAFRLLGLDGGRQMTSRIDLILMDI
LMPSTSGIEACRQIKAVERYRDVPIIMVTVKTDPVDLQLAFAAGAVDYVAKPLSKIDLLT
RVRCVLRLVHEIERRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAARESTPLSLIMLDIDYFKTYNDSHGHQAGDECLRQVAHLISSHVNRPGDLVARYG
GDEFVIVLPGTTVEGAGQVADTLRRKVGEAEITYSKGDTLTISLGFASTVPSRVASPTDL
IRAADQALYQAKQEGRNRIKQAGVLSLVHHTDKD
>A0A380A0W8|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MNKLKQTLFWCFLLFIWTLSPSVLSAEIALDSPYLFHAQADQQPPKQFDAVPNWMGQLDE
ANSVSLTGGDYWMITPVMVNQRQSNWVVDASNSIIESVDYWILGSDGSSQHAHSGYSAPY
EFLFDYGRKVTLNMGTDYWLLVKLSSRYYSSPPEIALQSLTDHQLMSDRLAMAVLLCLGG
LLFIALYNLLIYISILDKAFLYYGLYVFAYFGGWALTFHLPAHLFNFHYLELHHLFFISL
PIFNIMFYKHFLQLPSYSPRLWRLSQYLMFACIVALPTSIWLLPYTAIIASVLIMLWIAL
AITCGNVCLMKGFAPARYFILAFTCLLLPAVIILPGNMGLTPDFIEHAELATLMGGTADA
LLLSLALANKLKLLAEERKAHIEELAIAWEKARLDGLTRVGNRYAFDEYMNSQLGFADKV
VQPMALALLNIDSLKSVNETLGHQEGDRLLQVVVQLLQATDLAHLKLYRISGDEFVVVTS
SAGIPLLLSSLNGLGEQLASQGFKDCQCSFGISLNSEVADPHEWLRSADTNLYQSRMDKR
RQEYVDTRGVDVRLHLS
>A0A3S4QBA8|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MNLSVQNMIELDSPTLIIAQAIVQWLLAILLMAERGMDKGTKYWVIALFIHGIANLLLFS
RPYLPPVVAVIFYNFCVTTAFSFSYLAFARLVGKQAPLWLVLFPIFVMILTMSIYIDDIA
MRVIFASIITGTQLILMAFVLTRGNWSGSEKLKGWLMYSTGLFGVGFIVRALFCYVKPEL
FIHLVAKSSFQSGLVIAGMIYIIFSTVVILLVRLDRLNKELSTLASQDSLTGLFNRRAFM
HNATSIIASENFPVSVLMLDLDNFKKINDVHGHNAGDTVLKLCANALQDGLKQYGIIGRF
GGEEFAAILPRADSEQALVVSEKLRLAIETINVNPDIRLSISIGVATSSSVSSIEPLLIR
ADKALYEAKSKGRNQVVHADLLVLN
>A0A380WKG3|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MQFIPSALLLLFAATFLCIWLLERRRRHLLLFALAFLTISAATVVQFALWPADIGYNTIV
CAALYSAAPLLLVQGVLLRSGQSMARAEQAAWFGGIVVILACFYYIQNDLTVRVYVLNFG
MGGILLSGAWKLRHLVRGNIVDRVMLWLLLGLGATFVGRTLLTGGSVPTDDVDAFFQSAF
WVWAQFAMSVLGVAMGLALVVVACADVILALKAERDSDPLTGLLNRRGLQGKTQRLFVKG
VGKPLSIVACDIDRFKAINDSFGHAAGDIVLSGVAGVIRSKLRAADIAARTGGEEFVIVL
KDAPVDDAFGLVETLRREIASVRFAGMPDDFAVTCSFGIAKLHAGESLWDAIGRADKVLY
AAKRAGRNRTFAEGLQLSNAA
>A0A1J5SF85|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSLLPKKYRLLAWIGLALVAGFLTISIAAYLASRDAIRLGIARQSLPLTSDNIYSEIQKD
LLRPVFISSLMAQDTFLRDWILNGEKDTGQIVHYLEEVRQKYGTISSFLVSARTHRYYYG
GGVLKTVHRHDPRDVWFFRVEAMSEPYETNIDFDMANRDKMTIFINYRVMDYHGKFIGAT
GVGLALDTVSRLIDSYQRRFHRSIYFVDPGGKIVMAGKTMQRSGGSIRELPGVKRVAGAI
LNGSTVPTHLEYDLDNSSILVTSRFIPELGWYLVVEQDVADDVRPVQRVLMMNLAISALV
TLLVLGITLYAVNRYQLRLERAAKTDALTGLNNRQAFEILIEQAVLEFGRTQQPLSMVLF
DIDLFKEINDRFGHLAGDRVLKEIAVILRSVGRESDAPTRWGGEEFLILLKNCPLERAAA
VAEKLRLAIARHRFALAEPEVPVTVSLGVAQYRGGETQNDFFMRADVALYRAKRAGRNRA
EAFSDASPA
>A0A1J5QZA0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MEKRDAGGAQARGDGLRRTVARFCATLGLGSFEQLGELIHAGQHGPAIARHRAALIQRRV
FGFAALFALLVPAWALIDLLVLPRALWDELLATRAVSALALLGLAWLARGAPDLRRARVL
LGALLAITPLFYLATAHWIHAYALQGLALAAAQLYAQLPFVIVAGLALFPLTVLEFHAYA
LPLLAVALAGMSFHPAAVLPHAIATLWLLVLLLGVALLSALGQLRYMLAQVMRASYDTLT
GALTRRAGIDVLDLQFRLAAINASALSLLFFDLDHFKSVNDTFGHDVGDRVLRDAAHALS
KAVRKGDSVIRWGGEEFVVVLPTADAEEADAVVDRIIASGLGRRPDGAPVTASIGVAEAR
ADAPQDWRSQVEIADRRMYAAKAGGRARSVGVRGQARLWRLAPVAEA
>A0A1J5PP36|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MRDTFRFHDQLYRFGGEEFVVLMHCAHGDQAAVALQRLRSNTERHVFPQVGQITVSIGFT
EVRQGDSPSGAFERADKAVYYAKEHGRNQVCSFEELVAQCKLSTAPANVGEVELF
>A0A1J5RYX3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNELRVLFAAISVGNMAKIIGHLQAEDCEVHYEQASDEVTLDGHLQQNWDVLLLGSSAEL
TIETVVYALRCRTLDIPLIVLNDGMEPLPLAEAMRLGAQDCIALDQMERLLPSMQREMVS
AILRSNLREQVVADYLMQEIDQLILRGYDMRSLNERICRRMAELFDLKLVWIGARMEDGR
VEPLASAGESAYLEGIGVRWDDTPQGQGITGRSIRGNKAETMSLDSPRFALWRERAERYG
MRSALAMPLGIKNEVAGALVMYSAHENTFDKLTISRLSAFAGRVTVAMLGAQEQQELRLM
QAAMNNAANAMFITRRDGVIEWMNEALSRYSGYTTDEITGSNPRIFNSGEHQPSFWSEMW
TTVLDGNHWRGEIVNRSRTGGLYTVAQSISPLYDGKGELTHFLAVQQDISEKKRLEEEIH
YLAYHDSLTHLPNRMLFRDRVQQAIAQAQRTQTKLAVMFIDLDGFKAVNDLHGHNNGDCL
LESVAERIRVCVRSGDTVARLGGDEFTVLLRDVKDRESIRGVAKKLLDIAVQPYALDGEA
EATVSFSIGISIYPEDGKNFDALLSRADQAMYKAKQGGKNRHLFCSEQT
>A0A1C5RHT9|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKLKWRGLQFEHYILGILLAVEWIMSFTFLGYIHIPPISITTAHIPIVVIACLFGPVESS
VAGLFFGLGSMYKASALYVMLGDRIFSPFQTDFPIGSILLSVGTRVLFGFLMGCIFKIVN
KSRYKWAGKSLAALIATPLHALLVYGAMGILFPESGFNYKSSFRWGVNDYAIAAICILAV
ILSDIIYHSSFVTHYKNVINDSELRQHWSVKMKMSLFIIIIFVFCIAAFSTIYFASRTEY
MFGVYGVKVTKKIAQDILHLQVQFLAAMISLNFILLVIILMIYNYMKHREYMGEMDALTN
VMGRRLFLNYCTKCQNDRDDIDNKSKRKGWFLFIDIDWFKQINDTLGHTVGDETLKQIAE
SLKNIFSSYGAVGRVGGDEFAVIINEKMTKEQLEEQLKKFLLDISAILPERTVSCSIGVY
HFGFPKSQKELLTRTDDALYKAKEKGRACYVILDE
>A0A1C6HYR9|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MAYMDTMTGLGNRTAFLEENKSNAIFPGMISYIMMDANNLKTINDTLGHNKGDELIITIA
KCMRKAVGHNGQCYRIGGDEFVIILKNKTAAETEEIINKVRCEIEFADKQSDITISVAIG
YVWTDTEQKNLEDLMQHADDEMYKDKKKTKENKSKENTHSI
>A0A448Q5I6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MPSILDLLRSRLSSLLPSELKPSELRHLLSPRRHPLLLCQRRATLIVNRVRLFAFLFAVL
TPLWSLIDLMVFEPRLWAALAGFRMMACLAFTCLLLFYRPSGNLLDAYRAIAILFAIPTI
FYIASHTLLGSYQLAQFSAVVGAGYAFLPFVLMAGLTIFPLTLVENLVLSSLLLLAQALA
GYLSWATLNWPSFAGAFWLLILIAGVASLASMSQLAFMFALVRQAIRDPLTGVFSRGSGE
EILRLQWDSAQRKDGPLALAFIDLDHFKSINDNHGHESGDQVLREAARRLVATLRGSDSL
LRWGGEEFLLIMPETDMQQAHMALERIIGQGLGVRPDGAPLTASIGLAERRCDQVADYRD
LLELADKRMYCAKTSGRNRLCAMEPEAVQPPQAFAVGG
>A0A1C3HMX9|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MRLLRKNRSGNARPTLGRVLQRVHLGLALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFEDRTAAREALMLIASNEEVSDARILDNNGKMLANWRHPTDGPLHGLEQ
IVAHWALPEPVILPITHEGKQVGQVWLSGNGGSLLRFLLRGMVGMIACLVLSTLCALVLS
RRMLVGIVSSLDDIANVAHAVRRDRTFGLRVPSAPIAELHELSNDFNGLLDELEAWQAHL
KQENDSLAHRATHDSLTGLPNRAFFEGRLSRALGDIEPSAKLAVLFIDGDRFKEVNDSYG
HAAGDAVLTTIAGRIRAQLRETDLVARLGGDEFAVLLAPVHGTEDVLQIADNIIDCMTQP
VILPNDEAVITSLSIGIALYPDHASTPQGLLHEADDAMYQAKHRYNGGWRLAIHK
>A0A1E3L3F2|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MNNEDSLIHPLLKLAFDAMEDLVYIMAVENRQFVYCYVNRKAELSSGITSEYMGKNFFEL
YSERNQYEMAQYLHNKYSKVLIQAQSVRFDEGHLLPTGTLSGDSIISPIFDEHQNITHLV
CMTRSYDERHHYQEKMQYYAYHDELTQLLNRRFLYEFVTQPAYLFMFDIDNLKYVNDTLG
MESGDTLLVEVAGRLKRNFSSDYISIRLSGDEFILVSNREQEHPEQMAKIIISLMNEPFL
FNNHQIKINVSVGIAFFSEDINISIALRRADIALYHAKTSGRNKHHLFCESTQYEQVVRF
NYELALNSCLEKEELQLLYQPIYGNKQKQVVAVEALLRWKKDHKYMVSPADFIPVAEQTG
LIIPIGEWVIRQACCDLTIIQAKYGQQTKIAINISRIQLSEPDFIDRINQILKEENVNPH
YIDLEITESVAMIDTVSERSSLLKLREQGYTISIDDFGTGYSSLSTLTRLPIDNIKIDRS
FVAQMNPPVLKALLAMAEALELHVVAEGIEEEEQWRQLIELGCNDFQGYWISYPMPLASL
PDLPHFLSSFSNDYL
>A0A1C3HA63|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MDIDRFKTINDTFGHALGDEALAALAEELLIGLRNVDIVGRYGGDEFGAVLPNTSAEQAE
IVLRRIQQRLDAVIFKEAPQLRLQISAGIANFHPALGGYLDWLKAADGALYRAKQNGRNR
LEKAAPTGD
>A0A1C3HCJ5|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MTYIASISTLYSDACITYATLSVSYFVLSKSAPFSYRSALWKRVVFGLLAGVAVLYLSQD
RLALTDKVHYSFAMIPMILVTFFGGGVSGLVSFLFAMALTGGVTVDNLFIASIIAPLLLS
RVWLKKSHRTFYLTIGVIALYRIAVVWLLVDLSGLWTDVLLYQAVSALCLAICYHALNFK
ERHIYAYFAMRARATTDSLTHINNRASVDYQLMLQRAERRPCGLMILDLDNFKSINDTYG
HPAGDVLLASVGRLLQNSVRNEDFVGRYGGEEFMVITASYDPQVIGGVAERIRSAVESST
FLLNAHDEAHITLSIGVSLYLPGMTLDKAIAMTDEALYEAKRSGKNRVVTSRVMQLAPLG
AGFPRE
>A0A7W5G4L7|diguanylate cyclase|EC 2.7.7.65|Halomonas organivorans|TrEMBL
MVEPRSPRSRLFTLAIGIGIVLLLGQALWFYLMGHYTRILLPALLSPVMAVAALLAATAS
AKASRAAAYLVLICGFLLIAVELPGQSSTAALWIGLPPVLTLVLLPLGPAVLLNLALTPV
WLALLGNGELAPELAVGYLALVAVATLALWDRLRQRALLKATDPREHECPALTRKSLHER
LNGEFERARLLECPLAVVLFHLPQLDMTREQFGDATRRAMLTAFCQGTLRHCRELDTLGR
EDETAFWLILPNTTENGALLVQQRLQQALEQVVLVETGPLEVRLRLETPHGGERWPAFLT
RLQGMTQALATD
>A0A1C6KWE2|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKVILRIVALVILMIALAIGILLSQGYALPGQSEQLHYEKDWYLQIDEGQKEKVTLPFS
YTYGGKVHRLSTTLSYSPDSNAAPYAFIDNHHAYFKVYVDGREIYNYTAEDTPSVSKSPG
NAYSMIPLPRDCSGKELVVEFYPTLKVNVEYWMEDIIFADYASFMRLQFFDWLPQNIIMI
LYFFIGALMIMSSLAIIKDKESRRLWYIGLFAILFGIYSASENRFNLYMIANPYLMYLAN
FIVFAAFPLPLLMFFRESVSKTYKKFYSVIVGADVLNLVIQMILHFGGILDLREMLPATH
ICDLGGIIVIFYTFMKSPEDTAKRKRRTLLSIVPIAAGMGMDLVTHYTHVIEAASNTLYT
QMGILLFLAMGAGSMIKTVLNSYKENLKNRYYKTMAYQDGLTGLYNRAAFQEEQMRIDGC
REKYSNVICVCVDINNLKQINDDNGHLIGDQVICRVSTYLSDTFSTHGKVFRIGGDEFVV
FVYDLDIPKLVQLLHAMGERVKTDNQTKAPPAIFAVGYDCLRPDEKMEVCVKRADDRMYE
LKKKQKNKSR
>A0A1C3HHF0|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MEISAPNTFGTHKGVVLTHSLLVALATFLLALLSLSLSSEARHFTPLWFPTAAAIAVLYR
HAPRHWGLPLLASGIGIVLASFLLFGVSATPVKLAAINLLEAAVCALLLRRMLHPYDPLN
DLASWLRFVVCAVIFTPLFSALLAAGLVPAPDQPFWQAFGTWFISEAIGVLSLAPIGLSY
NRRTLTALNPFPLLLTLMVTLAFSFMALTYLPFPFTFVILPLLWAAIALPRFEAFTVCFC
TLLLITVMISLGLLHFQASGKHLGDLGLYLPMLLILIPAHAMAVVMHAFRVEKQHIVESE
SRFRSALEYSAIGMALVSPQGKWLQVNQALCTLLGYPPEALHKLTFQEITHPDDLNADLS
QLHDLLDGHISSYTMEKRYIRSDGQTVWALLAVSLVRDAEGLPLYFISQVEDISDLKRSQ
AENNRLVERITLANQVGGVGIWEWVMSQENFTWDQRMFELYDLNPDQTPTLALWRTLLVP
EDRERTDRELAALLADPKPFVMEFRITTRGGKLRHIRGQGNVILDDLGQPLRMIGTNIDM
TELKILAEALHEEKERLHITLDAIGEGVISTDSHLRITFMNPVAEQMCGWPLDLAIGMPV
AGVVRLTNGKDGPEIENLTQYPRQWPADYALVLHSRDGRYFDVQQSVSPLKTLDGETMGA
VMVLQDVTASRELMKKLSYSASHDALTGLPNRTRFEKQLKAAIAASGEPSSLHSLVFLDL
DRFKAVNDTAGHAAGDALLRDIAQLMRHLLRNSDCLARLGGDEFGLILFDCRLEQAKSLM
QQVVNQISQHPFYWEGKIYRVGASAGITRIGGDAKSSELLAQADIACYTAKHHGRGQVYL
YETRQKQLLERQHELLNPQEVQTIISKGLLRLLTRAVAPPATPLSAAFHQVKLQVMAPDD
RPLPHEAFIAAAQLYGLMPDIDRWAVTQLLVSYANDIKRKGLSLALPLATDSLLNADFQR
DLTETVRASSLPPRALLFSVDEAVVLEHAAQCRACLRELQQLGCRLIVNGFGHNINTFDE
LGDQKIDIIRIDERFITNLHCNQMDELMVSMLNGAAHRIKAQTLAGPAHQPVTLQALHDV
GVDLADGDQVALEQPLAVLLSDGYFGIR
>A0A727UAI6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7I6Q7X2|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP3-W18-ESBL-02|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNELLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYQAKQNGRNQVCTED
>A0A378P920|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MVFPVVMIVLGIILLISGAYLINKLLQKTNHYRRQWLSYLAFIAVFILSYSASIFYGLLV
DPHCLNNFYASVLLLGATYIYSSCRLITNTIQKMELMDDFKNRYEVLRHHATYDSLTGCN
NREYLFEMMNTRFQQIKMNGGSVIVLFIDMDRFKTVNDRYGHGVGDTTLHMFGGLLRQRL
RRDDVVARYGGDEFIVLMENTSIDEAKKIAENLITVTKKSLKEGTLSELNLGCSIGITQM
NHHSASVNAVIKEADLACYAAKQRKMNGSVCVYNSMITSKNNAINFSGNQITP
>A0A090NBS4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDTVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A090NGB2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIILPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A378KTJ1|diguanylate cyclase|EC 2.7.7.65|Legionella quateirensis|TrEMBL
MMPGKKEVIKHKVKLPLPSEYDRKYRLLTIITVELLIIGINITALNIYLHFWIIAYLLFF
ASCITLFNLILLKKKFNLIICGHILNSLCLLVMTVGNLYLGGVSSSYFGWFYLSPILAAA
TIGLEGLIFYSILSASIVTIFIYQFISPVYHVSAAYLPYIENINHIFIFLLTFTLLYNLL
KENKLYETVLKEQNFLLHADKQKFHYLSNHDSLTNLPNRSYFNTQLQHILDLSQKTKNAV
TLFYMDLDGFKKINDEYGHEIGDILLLQVGKRLQNCFRNNDIIARLGGDEFTAVISYKPK
DLILDVIINRIEQEFSQPFHIKNMDLNSTISIGTANFPDEATNAESLLNLADKNMYKNKK
MKSKHNKHKQ
>A0A2R8CMX2|diguanylate cyclase|EC 2.7.7.65|Kushneria phyllosphaerae|TrEMBL
MINALIRQEAPETDVHNVFMSNSYVMEGNHHKMSHCLPPADDCPSIEALDKLNIAALVYR
CGERITLEGANRSARILLNHFDPFEEDEPWHWYPDDKGDHPAHDWCLDDNAIEHGQAPRV
RWLGFKGSQRRLALSLTGCRLASDGETTRIMLVLQDCTRQIVQHEELRRSQECISSIINA
TPMGICVLTEDGRFEMVNPAYCRFHGYEEHELIGRSFSMLVPYSSYHYLQCQHRGALGSG
HGHTQQFGECELVARNGERHTVIVESVRIEGEDGRPRDVVFLVDISERKKLEMALEEKNV
RLEYLATHDELTGIRNRRFGISSLEAALEQAERQGLEISVALLDIDHFKRVNDDYGHTVG
DQVLQQFAEVLSRQLRVSDILVRWGGEEFMLILPGIDVSGAFQALERLRHSLALEYLSPR
GLQVTFSAGIINARGMNCNDLVEGVDQKLYQAKGRGRDRIVF
>A0A2R8CJW7|diguanylate cyclase|EC 2.7.7.65|Kushneria phyllosphaerae|TrEMBL
MLGIYEQVFGNSDHRRLARWLRLMLFMLAYFMLALGATELSNIEAAVVAPWLAGPLAIGA
LVRLHPRDWFVPLFGIALADLLAQYFCHVPGDVLFYTVINCIEILVGAFWLRWHFRGPLL
IATASSFLSVLLIGAFLIPLVSSLMLALTASHHDLGFFQMWWIHYLSGCLGMLVMLPVVL
KSSISRWHGLLSSGVLTAFNAVLLLTVLLNAGIVLFFPDEMVWSIVALLLGALLFDFFRS
TLLNVVSVISLVLLVFFYQQNGVSHIGMLHYITIVLTVLPALLLAMALQDSRRERAQLLQ
SEQRWKSALEGSGQGVWEVDLVRRQISASLEANRLLGQGDCADCSMERWREKTHPDDVVR
VEQAFAAHVAGHTPLYVAEYRVRQKDGSYRWYQSRGKVMQFDEYDHPLKMIGTLIDIHAV
RQAELEREQLARDLQEEKERLQVTLDSIGDGVIATDMAGSVVFMNPVAEEITGWHFSQAR
QCPLQEVFHLHGADMTPQSLELINTCLSRNEVCMTDEDAILINKEHRVLEVKATVAPVRA
AGGSAMGVIVVFQDLSRARELQRRLTFTDSHDALTGLYNRRRFEQAVEDAIRQEASTPAI
LVVLNLDHFRVINDSAGHLAGDALLIEIARLIEQHLGEQDVLARLGGDEFALLLHGRDLE
ASSSWVDTVIEAISALRFSWDGRTHEVSVSAGLIPVDSHAESFGVLLGRVNVACYTSRQY
GRNRATVYHPGQQDIEQYHRDIFMAAGLREAIENDRFVLFCQRIVPLQAEGSDYLEILVR
MLGREGEVVAPGAFIPVAERYGIMAAVDRWVIERALVHDGERLKQVLNGRSLSINLSANS
LNDPAFLPWLQGILSISPLSPQALIFEITETALMNHLDLARDVIDALRKAGCRVALDDFG
SGLSSFGYLRNFVVDIIKIDGGFIRHVNDNALDQVIVDAINQIAQRLGALTVAEFIEDGA
SAERLVKMGIDYGQGYYLHRPMPLDRLWLQ
>A0A2X0XAE8|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MKNLRIKLLLSLIAFAVILVAVISYVNRQILVTEIEKQVSMNKILIENHILTDMQTVDDA
HFYFDNNISDKMEQELRQLKNYYHENPNVSTWDLQQMKKKHGMDIYIVDQSNTVVYTTFA
KDIGLNFSLCCQRFSALLDERRASGEFFTDGLDISTSTGEYRKFGYLATHDKKYLLELGI
DLLNDPVFQTFNFEKTAQYLIGKYIDLVDVQAINAGGVFFNDSRSKRITVQEQSKKFQEY
FELAKKTMEPVEYEKALDNGYIETHRFLPYEAETVRGESSKRIVYVKFINFTKMEALQKN
TKQFWILLSIALLTSFIMLLVINKILSKTIHLATFDPLTGVFNRATYIRKIDNLLRKRKL
NVPGLLLIDLDNFKQVNDQFGHVEGDHILIETAKILKHVVKQSGFVVRFGGDEFAIVLYD
TTEEQMQHIAEDILTQIRSVRYDGQASEKWSVLSVSMGGAIYNHAEDTEMSLFERADKAL
YQSKNAGKDQYSSFAEVAADEDYIS
>A0A0C7P3Z5|diguanylate cyclase|EC 2.7.7.65|Defluviitoga tunisiensis|TrEMBL
MDEDTRLSKGERDFLLSELEKNNNCFYKDEIRGFDKSSILLLDELNELIFIINNEGKIVF
VNNIVTSYGYSKEELDKKFVFEFFQDKTKNLLEYFFNKKNINKLWIFKDQFLAKNGDKIP
FEFKLKNFFQNEILYFILIGRDLSEYVQYQKEIENLKRDRTIAEKAIQKSGIGIWQWDIL
TGKIVYDEMYKILLGYQVDPFKGSFEKIMEHIHEEDQEKIIYNIKEHFFERSETFSSFYR
IKDVKEDYKYFFSRGVVIERDRLGLPNFMIGIYTLVKECEEKFKEIAEGKNYLQKIIDNM
DQGLVVIDSNYKFKLANTFFYTSLNMPENIDSIKNIVDKDHMSLFEEKINELKNKKEGTV
SFECKLINKNNEYVYAFVTGLSYDGEAEEIILIITDITQRKKFEELLRKYATIDDLTDAY
NRRAGFLALEKSLEIAKLKKEPLSVIFIDVDNLKTINDNFGHDAGDFVLRKIADIIRNSI
RDSDILIRVGGDEFVLGLPSARKQDAEKIVNRIKEALNNIKIDEDMRIDLSYGICEYNDF
EKDLDIEDLIKAADNKMYEMKKSKDKST
>A0A3P5WQM7|diguanylate cyclase|EC 2.7.7.65|Arthrobacter ulcerisalmonis|TrEMBL
MAETAYSEDGPRRPVPAGKVLPARGRGPTVMMGYWDRDLHNAVADTALATWFGFTVDAIK
GTHLSAVIGETAYQDSLPQVAGVLAGAEQHWTRQMLNSSGETRTAQVALIPHTRDGEVRG
FISLFTDLTETLAGESQAKDSLERYRALARSIPSVFVLLYDADLRHVVAEGQALTAFGFR
EHHIEGRTLFESLPHHRAVELEPRYRSALAGTEVTWTREVGDRVFSLKTGPVETDGVVSA
GMVVAMDITKARQREQSWAALHEISTAVARSEDTASVTAKVSEVLRRLFLVDNASVIRFA
PSGSVQIVAVSPNDRDIADDVQSHQSGSGLATDIIWHTGNAAIAHYDARSEGGAGVMFGN
GFRASAAAPIHVLGDLWGAVVLSSRTKERVSEEVLGRLSEFANLVEIAIGNTQARAELEQ
QAKTDTLTGLPNRRTFQARLDLELSSAAATGQPLSLVVFDVDHFKSVNDTHGHSTGDLVL
AEIARRLRRAARHGEMLARLGGEEFVWLLPGVAAEQAQAAAERAGLSVASERFAASWVVT
VSSGVCDLASAGAANLLDCADIALFEAKRQGRNRSVAYRAPSPE
>A0A5B1CJ35|diguanylate cyclase|EC 2.7.7.65|Rubripirellula obstinata|TrEMBL
MIWLDFLIALSCGGAGLACGWVMHAMDGIGGESNPVAASKSKCAAASSDPTVNDDADDPE
AQRELVSNAADRLKSYAYAMAADVDAHQSKVQAVNNSLNESADASPEAVSEAIHQLVEAN
EEMQSQLQSAQDRIHEQALQIECAEKRAETDALTRVPNRGAFDRHFAQRHELGSGVASTL
AMLDVDHFKKFNDVYGHRAGDEVLRIVAGMLHSRLNERGIVARFGGEEFAVILDDCDIDQ
ASQYVEEARQAISQREIHFEGKRLRVTASAGLAQLSLDSSEQGDGQQCESLEQWMQRSDD
GLYHSKEAGRDCGHWMDGQTPVKIELSKSSGLESTPVSKTEAPSTAGEEVNEQAVNEETV
SQETVSEETVSQETVSEETQSKVEKTGDDKLSDDKTGDKDPSEAKDVVSENETANETASE
ETSEEAADVEDADEPATGPFASLPNRKAMAQEFSEMQERAGASVTTFVMAIRCHTEASAS
AMRSLLQVTRATLRNVDRLGYQDQSTLLVCMPSVDQETARTRGEQICRSAGSIGLSSEDG
EDRAISIGVAEIEAGEDFDQVVDRSVTMANQGRDPNRDIVTFDAESAAAS
>A0A2S6QBZ8|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MYLIGILQAFGIVLGDTLYNLYIKFIGINFDIKAFTFPLYYLIGNALTMMILAGPGRFAT
DTLKNIGTWVYGVAYLLSFVVEIYLIKYVSSTELSILLRLTVPVCIILSLVFNNRKPTKY
DMITVTTILIAMSVIFALQDPAYLINIALLCLTLAVLEAMGYFIPENHSTNEKAIKESGI
RGQMRVISFATFVTSMMVFVALLVICAIDKYFGLFNALGFETSLVSFADFFHLPTVLTGV
VFGCCIAPFIRFFQWSASYKITSEGVLTILAVIPLVTFVLEWILVRTGISPTSHFFESNN
SLILLGLSIFMAVGSWWGAYLKSRKHLKDINGSNIISKIKNAVKIKDKVISIGHSVNSMQ
DYEIVKITVDFYEQDFDKASETLDIPAETLKTLYYGKSSYTLKADYSQHIHKVFINKIFY
LDQLTKLENRKGFEAYFNELRSEKLDFSLYYMDLNGFKQINDTYGHNVGDEVLIAVAERM
MLFISDKKAKAYRFGGDEFAIIIADQTDEAKIKAELREMIEQPITVEQTDLIDTLTPRIS
IGKSSIFKEEDVKIKDVLQQADDQMYDEKVASKAARA
>A0A3G2HZJ5|diguanylate cyclase|EC 2.7.7.65|Alcaligenes aquatilis|TrEMBL
MSQPNIEEAAQDWHGLLQKVPLAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHE
QVHKRLHRSLRSWLVQLFSVDEYSDMQDQVRLQNQVGKVHARVGVPVHLVLRGARLLKGR
YARFLFESSTVSSEQAWECFRYVQSFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
AAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNLIDTELMPAFEQGDTKGQILRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTYGHDAGDRILRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMNITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYI
>A0A0J4XYT9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A7H4MQK3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MAHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A7H4SDW7|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHALAQSILANARTILINHQTP
LSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAPSAGAAG
>A0A0T9P196|diguanylate cyclase|EC 2.7.7.65|Yersinia pekkanenii|TrEMBL
MFCVGSVLYSQSAPLWLWLMLAINGLVWPHIAFLLAARSVQPFEQEIINLKIDSALGGVW
VAVMSFNALPSIVILSMMSMNNIASGGKNIFCKGLALQIACSLLTAWIFNLPFRPATLPL
QVYACLPMIIIYPSLFGLVTYRTAKRLAENKEELLRISVRDGLTGLYNRRHWEHQLHTQF
DSCRRYQHGATLILLDIDNFKSINDTFGHAVGDEAITVLAEELLLGLRAIDIVGRYGGDE
FGAILPNTTAEQTREVLTRIQEKLAELVFTQAPRLQLRVSAGIADYRHDMINYQQWLKAA
DSALYLAKDNGRNRIELAS
>A0A379IQ23|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MLDPRSLVFILAALSLLMAIVLSAMPSAVRDRQLGARYWSTSMLCVAVASVLYGLRGVVP
EALSMVVANAAAMAATALIYYGGRAFFGLPRHSGKLIGALLLANLGLVYCFYVQDLYAIR
VVIFSSVSGVLLFLFGLDVLRHRPRESGRAHFPYLFTALTVIFDSLVSLARIVNAVLHPT
GGADFLAPTLLNALYFATHGLLAICISVGFILMLNERLHALLEHQLSHDPLTNAYSRPMI
FELAQRELGNLRQPLSLLLLDIDHFKQANDNLGHQGGDEVLKHFVRTLSANLRSNEPLGR
YGGEEFIILLRDVDVESARITAERLRRCVAEAPYRHSQGDYPITTSIGHATAHNQESLEQ
LLQRADTALYRAKREGRNRVEQA
>A0A2H6JBR6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin12|TrEMBL
MAAHLQTVTDDRPLAAPLAIPPAGTGRRPATAQRTAQRLANALSITRALQSTLDVERLIE
LFSIQTHPLVPHDGVVYRNASQAILYKVGHEARHNCTYRLMMGNQSLGELEFLRDMRFSS
RETARLEELLTLLLQPLRNTLLYRYALWSASKDPLTGINNRGALDTALRREVELAHRYGT
PLSLLVMDIDHFKSVNDRYGHTMGDCALRRVADCAASCIRGSDMLFRYGGEEFVVLTSNT
EWFGGLMLAERLRTAVEAMECTCNEVRLRMTVSLGVGTLETNDDPAALFARADEALYQAK
LEGRNRVQFIDRGAG
>A0A5E4T5G8|diguanylate cyclase|EC 2.7.7.65|Pandoraea capi|TrEMBL
MKTGEILRCDDSETDPRVDRDACRKVGLRSMIVTPLKHLDTTVGVLKIFAPTPSAFPDAD
VRTLELMSELIAAAMFHAARFETSQLYLQATHDALTGWPNRALFYDRLRQAVHLALRSSS
RLGILNIDMDGLKPINDKFGHRAGDAAIRAAAKRMNATA
>A0A1V5BI95|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin035|TrEMBL
MKKCLFEKLYCLSFSHKGEPAQLIAPLLDIVKKALNLCQVVVFERNLEGYKVVASSPLYI
GGFDEICGTKNCVRVELRNQKGWNIGVLFLVFKKRYKMTPKLKKIVNAFTCHISGLMADR
EDIASCELHLKKEIDRYRYLLTHDNLTGLYNRYYFEEHIKLLEGSDKYPISIIMIDVDGL
KIINDTMGHRYGDEALTAAAELLKYAFRKEDIVTRIGGDEFAVLLPETPQTVAIQRCRIL
SEALKKRNKTNKVPFLSLSTGFATSNGPDQPLMDVLEAADINMYGQKTKNRLKTSKAILF
NCRPFIAKPAENIVSI
>Q3Z1S1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A5E5P5C7|diguanylate cyclase|EC 2.7.7.65|Pandoraea apista|TrEMBL
MPDAMPAVPSQPIASPSSANDASDDALMFELAPVSLWLEDFSGVKQLFEAWRAQGVTDLR
AHFKSDPAHVSACSRRIRVIKVNRRTLAMFNAPSLDTLVANLPRVFRDDMLKTHIEELCQ
LWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEATFERVLISLEDVTELEHARERVTM
GEQYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVHPEFVERCMNEIHVL
DVNRHTLAMFVAPDKTTLLSRLPDVFRDDMRHNFREQLIDLWDNKLFQQREVVNYALDGN
EINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYVDEL
NRLERKGPYPVTVIVADLNGLKLVNDQLGHAAGDALLRRAGEVLGKAVAAPQIAARIGGD
EFALLLPSTDASGGAAMIESIRQLVELNNSFYPGTPLSFSMGTATCEAGERLEATVQRAD
LLMYEEKRSHYTGSVNERRALDGLPSGTGATGATGGAGNAGGSGRGSGA
>F5P4M8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSGSGGYRQPLAQPRHRGRTASDLEATGPSHPDMDLDARTDVRFRVLGVLR
>A0A5P9C533|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MLWPIANEFPRPMSQPSKPPSIIELYPEETRKAASLLKQAVPLMMRHDIPPNPVHYALWY
TYSRGSEPELNRRMDKAVEDFDVFPTETASRLFRDYIIRGELEEARAGQQQVIELVDDIE
DDVSHSVIGSQHYQQSLSQGLSALQEPVIDDLPSVLSDLQESTQLMQDQQEKFLYRLRAA
QQEITHLRGQLERAHMAATLDSLTRVFNRHAFTRLLERALAESQQGLALVILDIDHFKQF
NDQYGHPLGDRVLQHVGQLLRDLLPPGAFAARYGGEEFCVVLRDCKGFSEVIEFAEQLRN
KIQSLRIKVRRTDQVLDSITASFGCAMAEAEDDFESLLTRADDALYQAKRSGRNQVHPAK
SETMLSA
>A0A2G4AX14|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPHTTDPITGLKKRTLPLVVFFATFLMTVLCFILVAANQNRSLNENLDSFAQHQTLSLKA
FIDNDVAYIGSGANFFYSNDVDSRDRFDRFAQQTINGSKSLIGLQWMQKVAVEDLAEHTA
KMKAQYPSYRMFTIPKHGPKTYGYVLDGEPVFIATDIYPNDPVNNGVLGFYSSRERFNLV
IDNIKKTREANISDKVRLLQDGLDSNTPKSGMLVYHPVFDGQTDNLLGVVIGVVRTTYYF
EKLLASTVGDMDVYVRVTDSGFEAEDAPIMFETNGYEAVTGQHITKTITLTNREWIIDFK
IDACISFNGYLVLAGIGIVGTTISLLLAYIVNLQIREKERLYRMIDERTEELRFLANHDS
LTEIYNRRAFNKVLGQSIQSDKPFSLIVFDVDKFKEINDKFGHPAGDALLIHVIKVISVS
LKSGDNLFRMGGDEFGIISSITEHDSLSRYLECILEAVSESHCEHSSQLLSCTLSIGATI
RTNEDIEALLQKTDSMLYLSKSNGRNRVTIAG
>A0A142X509|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL14|TrEMBL
MASPGRTLYVIRLPMSVMLTSPDIEAPPRSTAPHPMDSSRLLLALTSLVREGVAERGAST
EEGVPLGVLRRLLAALHYRDPLTLHHSRRVALIALGIAERLGWEEHELYVLEAAALLHDI
GKIGVPDHILYKPARLSPDEADLIGIHHFTGVGLLQACRMDRTTIQIVSDSYAAGTSEHS
ELHQGARILTVADAFDSMSRDQVYRKRMSREQIFRELIGQSGKRFDRNVVSALQRWVETD
GLNVLRDEDCGSSIDAAVPVDSSTVGEAHTLCHVFSYLYLLETLYDGFYILNNDLKHIVW
SRGAETLFRRPARDVLGETWSRRSVGWVNPDGKPYIDETCPMQRLLDSPRAGCVNVQLPD
EAGKLQTYELLLLPILDDRHKLQGIAHCYRALDESRRRKGEFRELKLAATRDALTSLPNR
KELDNFMTKLYGQFAKSEDSAPFSVIFCDIDRFKSVNDAYSHVVGDQVLVDFARILQDEV
YSGELVARYGGEEFVVICPETDLEHAERRAERLRRTIAASLFGGDQKLKVTASFGVSQIL
RGEHVDDVIRRADEALFDAKKGGRNRTARRMPASEAASAAPAAASVPEQSSDFAARITGN
NEVTVYLKTAVAADILVYKLSGFIEETKASLGKATKEEVELTIGKSSLFGGWGNTSDRQP
IRIQVFFLGEDRSRGAAVRQEMRVVFSAVGKPKSTEQFQMRVSEVLDLFRGYCVAD
>A0A142X4X8|diguanylate cyclase|EC 2.7.7.65|Planctomyces sp. SH-PL14|TrEMBL
MPDPSLQRREWSPIVWVTLPLIPVTTCLIGTVCGASTAAVALCLPQVAIGAWVWGWIWGL
VLSLLSYAGWFLPVLAGKVPVSAVDHDSAIICAAVAAAFGMTVARLRQSFEEAYAIAGTD
PLTGLLNRNSFYDRIRSEANRGGRNGVTVTIAFIDCDNFKAFNDTRGHVAGDELLMTVAQ
ILKGSVRSYDAVSRMGGDEFAILFPELPAEAADATVARVHSRLKAVAYTRSWNVSFSIGA
VVFPQPGHAALMLDLADAEMYAVKKAGKDHYRVLILPDSNIPSVDRPEGHVRPSDRVSDA
PPRPRGGRSPTERAGDIPQEAGIATN
>A0A379HDF7|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MKHLGILCVFFVMFTCQVQSQTRLPLSDYFFETWNTRSGLPHNSINSLAQTQDGYLWIAT
WEGLARFNGQEFKLFTRAEINNLPDSGLRALTPTDDGGLLIAGSRGGISLYQYRQWNTQP
SASAMVNHIIKSNDDGFWLALENDGVFYRGANSKHDQAIVHNVSAYRVLEDANGVIWAAT
SDGLYKIVDQQASLITADDGLPNAAVYTLLLTRQGKLIIGSERGAYILKDAVFTAIHPQL
SVESISSLLEDNHGDLWFGTINKGIFRLSVAGLEQLDAKGGLPANRILSLLQDRENSIWV
GTNAGLFRLREAPFTAWTTKRGLAGDYVRTVLSHSDGSLWVGSSAGLNKIKNNNVTQIEG
AKEGSPYSVLSLLEGEDGDVWIGTYTSGVLKVSNNKITPYLNRSNGLGSNEVRGLLLDSK
QRLWIGSAMGLTRVEKDGSLVQFTNEKELPSGFILALSEDNKGNVWIGTGNGVVVFNILT
EQFSAISFPAQFAAEYGFGFYFDDDYTWMTTDRGLMRYEHSAGKMAILGREQGLPVDKLF
QIVAHKDSFWLSSNRGVIQVDRQHVNHVLDEKQKNINIPLVFQLYDEGDGMLSAQVNGGS
TPSATVHKDGTIWFATAKGVSALKPELLQASSKVDLPTMIESFSVNGRATALPLDGETVL
LPPNVSRLSFQYAGLSFIMPQRLSFQTQLEGFNKEWVNRQHMTGAEYTNLPAGKYTFKVR
AGYPNTQWQQNEQEIRFVIQAHYWQKLSFKLMLFFTFLVTIYAIYKYRLYHYKKVEAELT
KRVEKQTQDLQEQANAFAYQATHDQLTDMPNRRAFDSWLAANFATYKQQNKILAIAIMDI
DHFKRVNDGWSHIVGDKVICEIAKILKSHCEGEQQVARWGGEEFTLVFPNKTAAEAKLMC
ELLREEIANNDFSVIAAGLHQVTASFGVSDSNNIDDYDRLLSGADQALYKAKNGGRNRTE
IM
>A0A173YC27|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEGSILKHYKNILDLVPCGICQVALDDDLTILYANQFYYDIYGYTSQEAEEKGFTNARFI
LPEADFQMIHQNLLDQVVRGKTKFQMEYRGVHSSGKILWLLVQCTYDPNIPGSVLCSLMD
IADRKRMEDEIRMSMEESKTAFALTDKYMYIFDVENRRLFQPEATAEEFGLPVVADNAPY
SIVESGTIDEESRQEYIDFYESIIQGESKGQTVVKKRKKDGTTGWYSAKFAMIYDSEGRP
RRAIISSENITEQREKELTYQKWSQHFKAQEGKTIGYYEYNLTKDAVESGDDPPDYLRPF
EKYTETVRYIAERFVYEGDRARFYNFFNRDKLLLRYYNGQSSGNMDYLRKRDDGSLYWVR
ATIQLIADPYNNDVRLFMMTLDIDEEKTETLRLQRRVEHDGMTGVLNRDTFMTRVTETLE
ESGPAARHALIMLDIDQFKVQNDSYGHQFGDQVIKETAGILKHFLRRNDICGRIGGDEFM
VFLNDITSEQDVIPRIAQLCDLLKRKYPEKGEVSCSLGVVFYPRDGENFKELYRNADIAL
YEVKRAGRCDFRVYEGEA
>A0A550AK66|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MFNVQDCLSSSKQSSIDLDKWQQTVDLMSELYGSVNGSIVQFRQNEFNVVVTSSNEDNFL
ERDDSWPWEMKSFCRKIIETKKLLYVDNSLEDQYWQDAPPVTDGPVRSYCGLPIYWPDGS
LFGTICVIDNKASQYSTTLLKMLEQFCQLITADLKMFCDYEELKSLALTDELTGLYNRRG
LMILGEQRIKDAKRSKHIIGLTYLDIDNLKQMNDQFGHQLGDRCILTLAKALEVSCRDND
IKARVGGDEFIVMSVFDKDNEAPYNQVLRELSQRIIKNYQLFIKEHDPNGLTSVSYGGLI
FKHHELHTLEEMIEKADQLMYQNKQSKR
>A0A550AHH0|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MIHRQLFKVIQLKQPLVRLTLIWRTLTCLAILSCSPYTWAETVDSIEETFVLLESGKVIA
PKELQQRLTYLKANITADDIVKYRRLQRALCWSADAFDPDKRAEGLKFVQQQLTSALITP
SAETMADLKLCRGWFYQFSGQVELALEEYNQVVATAYQLESPRLIADARGLRGAMHSFQG
NYASALEDLFTAQQLYESLNLTIWSQYNLAEIATSYRRFGDPQTAYKYYEKLALLFTQSG
DLELAAGMTTEVAIALDELGENEAALDKYLQSYHYWQQQGDELAMSFVAVNLAGTLIKLD
QIDEAITYLDFAKNHVEPTEEAFYSFMMLFRAQISFLDKKPQAALPFLQQAKSAFKRVKN
DRGLSQLYILESQIHANLANWKQAYYSLEQYIELHNQLDIKQQSHRTTEMRTRFNTKQIE
IENTQLIEKQEVKERELQILQQNRYLQFTVIFLAMIVIINISFFAYKQAQKSKLLEILAL
TDHLTQLPNRRHAYTLGERYFSESASLSLILFDADHFKKINDRFGHDVGDQALTSLANIA
NAMMRQSDLVGRVGGEEFLVLLPNTNLQQAKEIAERLVKAIAKSDLSEINTELSITISAG
VASREQDKSFSELFQRADNALYLAKSSGRNCAKSA
>A0A173WRG7|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKKAITFRLCVVIITAMVMTALLGYYLQTKSAKEAMRTNSEIRFNQVSEVLKRNDTEIAE
LRENLKEDYFIRAKAAAYIVQNQPDVVKDLEEMRKIASLLQVDELHLFDMEGRLYAGSEP
KYYDYTFRSGEQMQFFLPMLDDVDLQLCQDVTPNTAEGKMMQYVAVWREDHGGIVQIGME
PARLMAAMEKNELSYVFSMMTTERGVTIFAADQDTGTIIGATGGIPVGTPLASLGLCLPE
DIGEGTLYSREMVLDGQKNYCMMEMTDGILVGVSATYEKLYENVPGNMMLIIFSLCVLSF
VTVFLILKMLDTFILNDIYGTIDGTQKIAAGNLDYRLEIDHTPEFKELSANINRMVGSLL
EATGKLSLVFQNVDIPIAVYEYNQDMKRVLATKKLGEILMIPEEELSAVLADRELFVKKI
KVIRSEPLKEEKEICCLNGEERRYVRIKTYEGEGKTLGIVIDVTEAIVEKQQIEQERDID
LLTGLLTRRAFFRTADQLFADPDRMKTAMLLMMDLDNLKHVNDSWGHEYGDKLLKTAADL
FAGLKAPEKLAARLSGDEFVLLIYGAEEKEELYACMERLEQSIREARIALPAGEEAEVSV
SGGYLIYPEVCADCTEMLHLADQAMYRVKRSGKGRFEKYGGPDAKEG
>A0A174L5X6|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKNVLALLKNENRRLSQQAETDWLTGLYNRMAVEEKVGRRLKKYETGVLFVIDIDNFKSI
NDRYGHLAGDQVLRGVARILQERVFHSDILGRIGGDEFVIFMSVKQDQNFIEERCRQIRQ
QFLNLPPDQFMVTRLSVTVCGSIYQKGDDYQRLFDRADQRLITEKSLRKKRPADADNRPE
NTSNMKSLKTDMEQVSLELSEPNPYAGAFCQDYDSFVGIYRFVERRLQRVQSSVYSLLFT
LADEHGDFPDLPERILLMEELHTIIQMSLRAGDVFTRYSSCQYLVMVSDATDLQTDGIAE
RIREKFINSSSFSDKYILIYKRYPLKPSEARGRK
>A0A085G4B3|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis ATCC 33320|TrEMBL
MSDNLIERISTALESEYTLEGLVRQLLEMLELVTNMESTYLTRIEPDGSFQHILFARNTR
QMQIPEGLSVPWGDTLCKRALDEGKRYTSDVAKVWGDSQAAKALGITTYVSTPVTLADGS
LYGTLCAASSEHRILTDRSEQVLQLFAQLIAQQIQNEQLLQQLQQANAALTTASYTDELT
GLPNRRAVFEQLPKLFSQARDDARFVLLAFADLDDFKEINDIHGHEAGDDFLCEIGQRLQ
KGTRPDEIIGRVGGDEFIVAGFGPSNTDEAQHAAQAFKIRLSNLLTGEFQLHSSVINYAG
PSIGVVAVNPAETDHDTALREADTAMYVEKAHRRGF
>A0A6B9G9J5|diguanylate cyclase|EC 2.7.7.65|Pantoea cypripedii|TrEMBL
MAQTPLPRQSEHPFLRVHLCFLAVFLFSALLTVHEALELKANYEERQRAQLAEIQKSLDS
QFQESVDGLVYYEKMLNYALAHPLDSDNAREAVKRFELLRREPQWQLQLESPRSMPLNGV
SDDWLAHDPLLQRDPTRISQELRAALEFSFIMQFSDPDQDFHSRFWYISRAGFFISSRPP
QSFQELAESYATMVQRSYFRSQQPQKNANSRLRWTTAYQGLFNEGLMLTVSAPIISNGYW
YGVLSMDFTQQRIRELMVEMRHTLLQGKLIMMDRSMNEVARLYAPDDEPLAPQELQQLKV
LMEQQPSGILRLGTQFASWSRLKNVDAYIVNVQSLKQGMQQELGRVSLFLFGMWMLFVLL
LVVAHQVIFRLVRRMDDLSERLTWRANYDGLTRLLNRSAFFEQFVAQAAHCQQLGQPIAV
IQLDVDHFKKVNDTWGHHAGDQALIRVASVISHTLRKYDVAGRIGGEEFCIVLPETTLME
AAAVAERIRSRLAAKTILVNASTTFNITLSAGVTSSEEQGDYHGESLQAKADSRLYLAKT
SGRNRVCSED
>A0A383RS10|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MIAHTPTLFAAVALVATILAFCLLLVGQFNRRDNLLLTGCGLLAHALAYVCYTLYAHAPL
WISYALGNSLLSLALAFYSASLFRVREQPVPWRAIFIIPAALLVGLMLLLDTLEPRMLLA
TLVLMLQCSLLLYWARRHVERAGRAHLLLVIGALISLVGLGMRVVAVVLGQAADMRYDTS
SLKQTVSVAIGTATVMMYAIGLVLMAKERSESRLQHMALRDVLTGTYNRRAILERFAVEL
QRARVEQASLAVAMIDIDHFKRINDLHGHLAGDEVLCHCVRQLQQRLRQVDSLGRYGGEE
FLLLLPHTGRDGAMTALQGLREAIAQTPARFAGADIELRFSVGLWCGVPGLDDSAASLLG
QADAALYQAKAGGRNAVHMAAAAAA
>A0A383RUB4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MPHAKKGLRLDLRTLILVLSAFTAVLMLLTSYFASYRVQRQLLIDHSLEANRVYAAKLAS
ITDLFIGNALKQLSFSAQVQARQLADSDALLAESERVLHQSNAFNSTFVVDARGILQAVS
PAPLRHLLGSQVDTPGVQEALRERRALVSTPYLSSANNLVVMLSQPIFASDGSYLGFAGG
SLYLREDNVLNSLLGEHYYKDGSYLYVVDRNRRLLYHPDGQRVGTQVSGNALIDQLAGLG
SGTRQLTNSVGVEMLAGFATVPTTGWGVVAQQPLAQTVAPLRQLILNVIAISAPLVLLGS
LLLWWLALIIARPLWQLAAGARALDRPGTAEHLHGVRAWYFEAAELKRALLFGLNLLQER
IGRLNRDAQTDPLTGLGNRRRLEFSLALLEAEGRDFSAIALDIDHFKRINDSHGHDVGDQ
VLRQLAELMRRCCREGDVLCRTGGEEFVMLLPGAPLEVATAVAQRLRLAVQDTAIPPVGA
VTLSLGVARWPAQGHAPPADTLAEADQAMYAAKRGGRNQVQVSGPIIAPALHTH
>A0A7X5JPD7|diguanylate cyclase|EC 2.7.7.65|Citrobacter pasteurii|TrEMBL
MFPNTMNDENFYQKKAVPNEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAEDPLYSEFTNIKTDAILAGMWVGIMGANL
LPSTALLMIICINLMGAGGVRLFIAGVVLMVVSCLVTLQLTDIPVVFSSTQLSVLLSLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRQQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PAASAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NAGRNRTEAAA
>A0A2H5ZS53|diguanylate cyclase|EC 2.7.7.65|bacterium HR31|TrEMBL
MATTVVPRSNVARPGAYRVYTLAWAGAGVLLVLLSAPALPRFPPEYLLFAALSLAGHLFF
VLDLPGGLRLSLQAILAPVWLYGWKAAPPLFLLTLPLVLRNSRGDPLRAFLYFGNGCVWA
AAAGNLFTLLRPGPSPQPTWTELASVLVSGAVFTAGSFLVAAFGRYLATGDPRVLQPRHA
IEGLTLVFSGYVLLAYLLLLALQTGPAAAFLAVGVWLLTAVAMKGLAETRRANERLQEAL
RELERLTVTDPLTGLWNRRHFVQVLPKELQRHARTGRPLSLLVVDLRSLKHVNDTYGHEA
GDRALQHAAEVFRDRLRGSDLPFRIGGDEFALLLPDTDTQGAVTVAKAITDLLTETRIEC
APAARLEATVGVATFPHHGRDPDALVAAADAALYRARERGLAVAAPEE
>A0A6M8MTE8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MYLHDSQPAREALIRGQVRNDRLQLLFRQSFFSVFGSALAAIMLSWICWERLEHSLILWW
LGLLGASTTLRLIMLTTYFRMPETARTPERWEPVYWITLVLSAGIWGGGALALMQAGDLL
IQTLVLLFAVGMTVSAVSCYSAYRSMTLVSIALVLLPCSLWLLFQPQTAQQGMAAASLIF
ATFVVSATRKLCRAMERAFRLSREMEHAHGIADHAAQTDELTGVKNRRAFFHRAERAYDT
CKRSRLPLCALMLDIDHFKRINDCHGHQAGDDVLRQIGRVICQSVREGDVCGRLGGEEFA
LVLANTTLEAAHAIAEKLRQAIADITCQHDEGVTASLGVAALSDTDQDVHALLGLADKAL
FRAKASGRNQTAVA
>A0A1M7Z2Q9|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MVDVFEQALSQFDIALATRLDLFLAERYNRNALFIKATRDSLTGLANKAFFMDRLRSTLL
TKMESSHPYAIVICDLDGLKVINDNLGHRIGDVAIKEFANCLRRATRELDTVARIGGDEF
GIISPLKSNADAKDLVQRLEAEVTKTVMYETNTINLKASIGFSLTSQDGVEVDHLLDLAD
QRMYSVKRNHYQKMRMQPR
>G7Z2W2|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MGRRLSIPWAGGGIAVSLLFWILLFSTLVTLVSTALQLYFDFRREVRGIEGRFDEIRLST
VPSMSNSLWVVDHDQLRLLLNGIIRLPDIQMAEVREHSATAKNPLVLTVGTPQERPGLHA
EMPLTRLAEGKTLTLGTLRVEATLDDVYHRLLTTAEVILISQGIKTFLVSGFILFICHRL
VTRHLISIAASMRRHDRLSSPPLLTLDRPAPSRPDELDQLIRSFNDLAGDLYAANCELAG
ANAALEHDIALRRSYEEQLYRQAHFDELTGLANRLLTRDRLEQAILSSRRNQLPSALLFI
DLDNFKNVNDTLGHEAGDTLLREAANRLSASIRQGDTLARMGGDEFLVVLPCIAGNVAAR
GVAERVLEAFAPPFRICGHDHFVTASIGIALYPSDGSDAPELMRNADLALYRAKERGRNR
YEFFTAEINERVQQRIMLESRLRLAVLRSEFVLHYQPIVEAGGRRPVALEALLRWRQPDG
TLVGPGHFICVAEEVGLIGEIGAWVIETAIRETADLFGKEASAPRVAVNVSPRQLRDPSF
VFRVTEALAAHGLPPSRLELEITEGVLMDEAPEVTDALHRLCSYGVRLSIDDFGTGYSSL
SYLQRYPFDMLKIDRCFVSNATDGAAAARLVETIIMMAHGLGMETIAEGVETEEQFDFLQ
SKGCDQMQGYLLGHPAPLAEIAARFPAADAPSARPLETVTGDGTAPAPCAG
>A0A4P6M3M6|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MAIEKVKEYFRGFGIEDRIMEFSQSSATVELAAEAAGCGPERIAKTLSFLVDGTAVLVVM
AGDARVDNKKYKEHFHTKAKMLSPQDAEARTGHAVGGVCPFGIPEDVQVFLDISMKRFET
VFPACGSANSAIELTPEEMEKYSKSRGWIDVCRGWQPEMPSVPELPKKYLSRMPGGFFIY
EADGDERITYVNENVLKLYRCRDMEAFWSLTNGSFKGMVHPEDLERVEDEIKEQIASNTY
DYVEYRICCQDGTVLWVEDYGRLVEEENGKFYFYVFLVDATEKIQLRKLLNRRDHLQRVL
TTLANDVDFDIHCKDCTIDVYGSFEQRFGRPPGKKDFIQFMCENCEKKGELKLFVHSYSM
EEQNFDKEDQDVVVVDGEGNNLWTRCQIAHFKGSDSGYDRKIGRMLDTHEQTMREIYYRQ
GAEKDCLTGIYNRRSGERFIKRRLKGIGQNTSCMMIMLDVDGFKMLNDTYGHPFGDNVLL
QVACALQSTFRKNDICARIGGDEFMVFLEDVRDKGICLKRLQQLVSYTLQDESVGQYNVT
LSAGVSYQTGNKLSYEEMYRRADEALYQAKRAGKRSFRVYSENDA
>A0A484YVW7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MGKRFAYWSWNPQDNSDTLGTLVSRWLFPNPVSQPIMHNGSKIGEIRLTARDSLIGHFLW
MSFAVLTGCILLASAVALTLTRSLHHGMVIAMQNITDVVHDVRTNRNFSRRVKEGRIEEF
HQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAAFRNSIAALMNDASAK
AHSALLFLDGDNFKFINDTWGHAAGDGVLIDVAERMVEFGQKHHRSYRLGGDEFAMILYG
IHSENEVQHICAALAQRFIRPFDVHNGHTASMSLSIGYALAWENASVEALLEQADRSMYL
VKNQRTKTLS
>A0A7U9N0X1|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MRGNAEMKRPLKTKVIGAVLLICLLIDFGCVTYNYRKYVSINRDYTAQLASTVINTCCLV
IDGDKVEDYLNTRKRDSDYYVVWNKLIDYRNTNPDIVKLSVMSFQEDGCYYIFDTDLTEK
GAFLGDSRPYDPWQLTARDSLLDYSSDVSLVYRDHTDIYIPIKSSYNIPVAYVVAGVATD
TMRAEQRRYLLYLVLIITGITVFAGGLLLLFMDKNILAPVNAMTAAAESYGEKREKDGEI
SPLQKLQVRTGDELERLCESMKKMENDILAYSARLISATWNSNHDSMTQLFNKRYYNELL
TALQEQENLGVIYLDIDNLKRMNDTFGHDEGDLAILRASALIHRYEEPGFECCRVGGDEF
VIFLRNAGERVADLVNCMRGDKGNLLSEITEEFICRLAVGGASRKAGETLEDVIKRAEEE
MYRNKHAIR
>A0A7U9QZL4|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MPVLPPVTHTHRPANYAGQINMFPLNAGATATPTDFRHGSSEVIFHDSLLAPVSHPLRLA
GAFALRVLSSSALFGSFCLFPIIRPASLFCQAEKFIFFFIAISQCSVYTVFNTLTLQEKG
DADSNTGTMESTKKTTKNKRGKLYYSFQAISMIPLLIYGIVVIIFSSATFRRSMQQQVYA
ELKNVESLVDTLLDTAYPGDYTLKGDNVLSLYKGGVNITADYSLIDGIKEDTGMDVTLFY
QDTRILTTIKNWEGERLIGTRAPEQVLTDVLEGGESRFYDKVIIKGTTYFAYYAPLYNGD
GQITGILFVGKPAAEVNNQVNTALSPMVIVGVLALILVCLFSMYYAGTFLKALYGLRTFI
SRVSTGNLSEELDPAVLKRGDELTELGRSALSMQRSLRSLVERDSLTELYNRRSGGHHLA
HTVEKARSGNTSFTLVIADIDYFKKVNDTYGHQCGDLVLQNVARILRRHIKGKGYAIRWG
GEEFLLVYENSRLEEARKFLETLQEEIRNSCVQSEGNQIYITMTFGMACNPSRELKDLLR
EADDRLYYGKNNGRDQIVSGETPSPAEP
>K1KPA4|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MGIVVGGILICLIVLCIRLHNEKAKLQRKIDLFKPMIETTEGIRDIVYYCEVYPKLKYLY
LSPNLDSILGPNSLEKHLKNPDKIFGIVHPDDLDILRKKQLGTLNFDKPITVRFQNHLGQ
YIWFEEYATPVYKDGKVIAVQGVFRNIHSQHILQEQLEYKSTHDGLTGLYNREYFQLKKN
EFNEMAIPISVIIADLDDLKEINDENGHQMGDRLIIAAADCLNKYADKEMIVARIGGDEF
AVIIPDKCALEVEQYIEKVHSEMNGISNSLPFSPIRVSIGYEYSPSSYGLMRQLFNKADQ
KMYKNKKMKKTIVSR
>A0A5E0ZTP1|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MSQNYFDALNVIKTPVWLISPVSGHIIFANTAAVQVMGDKTVDDLRKGAFSANAQDVLSM
YIPELKTDQEIIEIWTVWRDGHETALSCRLSLTHHAPYGDIIVFEGISHPAPTGLKASRS
ATYQRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYSHEEMCSKHTWEIN
TLGRDVIPVMSEIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLELELEHAALQDAMTGLLNRRQFYIIAEQMNLTHLPLQQQFSLLLVDTDHFKNIND
VFGHLKGDEVLIALSRTLEACSRKEDFVFRWGGEEFVILLPRTSLDTALQIAETIRAAVA
RISIPGLPRFTVSIGVARHNQDESIDDLFKRVDDALYRAKNDGRNKVLAA
>A0A411ZBK8|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MALTGLREMFANRRQAAEAARKAQMLDSFEAAGLGYFWSTDAHGNLEYLTPAAFGNLGWN
RKAVTGSPLSNHLLPAEDPDKASERPLSYLLSARNAITGLTVKLKTDIGDVWWEISGKPQ
FDVAGEFTGYRGSAKDITHDRAQMMRDGGDRRAQLDSLTGLPNKTQIKRTLTHTLRVFRN
TKQSCAVLMVDLDRFKQVNETLGQAAGNELLKQAAARLSRVGDKKATVARLSADEFIILI
PDVDDRGILGDFGQRFVQTLSQPYVIDGNQANVGASVGIAVAPYDGVETDELINAAEMAL
YAAKGSGKGKYRFYSSDLKTQARHRGEIENELREAIGKDELRMFYQPIIDAKTHEVRCVE
ALIRWEHPERGWISPGEFIPIAEESGVIRKVGAWALSQVCKDASEWPVEIRAAINVSAVQ
FDHDDFVQIAKKTIKDTGIDPSRIELEITESVFIGDYDGIMKIFKGLKGLGVRLSLDDFG
TGYSSLSYLRNAPFDKIKIDQSFVRGCTEPGNNNSAIIRAIVSLAEALNMETVAEGIEAM
DELDLVKQRGATHLQGLIFSGAISNDDLLSKLNSGELRYEPRGPEKYRADRRTEFRRIHL
IHDDHRYDVVLRNLSKTGALVEGLLNVPQETEVVLDLGGGQLAVATVRRSSDYTQGLEFE
TPLISDGADGLCTRHRVSPYQIEAAGQPLAALPDDPYAAMSDAGASKARPAAFSQVDLRR
RENAA
>A0A1V5XN89|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin207|TrEMBL
MDSLVRTILLARSALRHGLGVILALALSVFLVTDLTWNFDPRFRYPAALLFAVAFGASAR
ARYRQSDLVSSRGWQETELGMFSVLGLLGLAAYVDGNLDGSTYPVMFIFLVLLSVLAVPW
ATAVTVGFAISVEAAVRFIAFGEDALRSLLLHGVLASAFSLVGTIVIRAEVARIRTHSRN
RLDAEIERMHSAARSYRLLGATARVDDLSDENTPPSSDLDANRLARSSVEEIHQAVLFAL
QLLHRSLGLHTAMLLWLSDASPHLRISELSSDADNLLEGPFPMNDGIFGAVVTEKNTLTL
SNLKASYSLPYYTGACPVRALAAVPVMENDQLRGLLVTDRKDNVAFSSSEQDLLLAATRY
MLRAIQNERVFVQLERAKVEQGKLYRAARALGSAMSERDVVEAGVRSAREIASFDFAAVT
LFDEAKKMHVIRAVSGDSVQGLVGVKFRHNAGLVSMVVQNKHPLPYRGHYDPNRQVVFAP
RVAPAPMSSLLVLPLLVHERPLGTLVLGARRPGALGEAVRPTLEVLASHVAVSLSGARMM
KRLEELATRDGLTGLFNKRALLEMSQDKLAAAKRFSRKLSLLVVDIDHFKKVNDTYGHDQ
GDVVLKGLGVILRKAKRTTDAVARFGGEEFIILCEETDREGAMLLAERIREELQQTTFQT
PKGELSVTCSIGIATFPDAGTDWDTLFKAADEALYVSKRSGRNRCTAWSSRRGKAA
>A0A7U9QVT5|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MNREQAAKNKISVLKGVRIRTLSLWIVAGTILVSVLIGNGIINVMRQHQELAGMTQEYLL
IKDNITNMSHGSDYLTEQARLYAITKDSSYADSYFQEVTVTQRRDKALQEIEHHLQGKDE
NAFQSAKEALELSNELMDLEIHSMKLAALSTGETLDSLPVQIQDYPLTEEELQYSPEEKS
DSASQLVFGVQYQSMKQKIDENLTDVAQSVTSICEMEQAQSEQDMRNALVRQSIYTVFVV
LLVIFSYIMIAVLILRPIRIYVNCIKNNNVLEITGAYEFKYLAAIYNNVYEMSMAQQDIL
RHKAEYDALTGLLNREAFEQLKLKLRKNSSSLALLLIDIDVFKSINDTYGHAMGDKALIH
AANLLEESFRKADHVLRIGGDEFAVIMEKVQQDKPQIISDKIDKINWILQHPQGDLPKYS
ISVGIAFSTEGYNDELFRQADEALYHTKENGRCGYTFYQPK
>A0A6J4FXT3|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MARLLHATNIALVALVATLLAAMTAAYLLIFFGEREQRLEQDRWHWERQLGLIDGFIAEN
LGKHRYQDVEEFLLRWTRENGRVVRLEARFPDGTPLTEYRVDRAVPHVMTYRRDIRQQER
LRLTLDVAVDNGAIHAQFVAIGWWFALIALGFTAVLSALIWFIIRRLALHPVEAAWMSER
FRQQDEIRKLALVADTTSNAVVITDAEGRIEWVNAAFTRMCGYGLDEVAGRRPGDFLRGP
ATCPDTARRLSEALQRGESFAGTLVNYTKAGRPYWVEMDIQPIRGEDGRVERFCAVESDV
SQRKADEIALKRAASVFRHTVEGILITDEGGTILDVNPAFSEITGYSAAEAIGQTPRILK
SDRHDHEFYRVLWHTLEQVGFWRGELWNRRKSGEVFLEFQTITRIPAGADGVPGGYVAIF
NDITEVRRKDERIAHLAYHDPLTGLPNRTLLLDRLDQGLAMASRDGSHLAVLFLDLDRFK
NVNDTLGHQRGDDLLKVVGERLGDLIRASDTLCRLGGDEFVVVLTDSPEERAVSAVADRI
IEAVGRPVELGGTVVQVGTSIGIAMSPTDGSDGVTLMKNADAAMYAAKAAGKNTYRYFSR
SMSDKAMARLRLENELRDAVARGQLELYLQPKVCLRRDVTTGVEALLRWHHPELGLVSPA
EFIPVAEETGLIIPIGDWVLAEACRIAQRFVGLGLGDLSIAVNVSPVQFQEGHVAERVAA
LLEQHGVAAASIQVELTEGTVMGDPKRAIDVLGRLSENGVSVAVDDFGTGYSSLSYLRRL
PIDTLKIDRSFVKDAHRDVGDAEIVKTIVGLSKSLKLIAIAEGVETAVHADLLRAMDCDL
AQGFHFAKPMRVNDFLGWLAAREGREVSDSAQPAPSVASPFETAAGAASSG
>A0A128FDL4|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MRQLLKWLFVTVLFLQSGAALAAYQVLAIHSYHPDFFWTESIVRGIEKGIEGQDIVVEHT
YLDTKRIQSPDYHEELKRLYLTRLEEHRYDAVLTTDNAALWLVNELSEEIGNVPVVFSGL
NSASLEPYQSINMLGGVEELINVPANVSLIKNLHPETERVWLALDDAYSSRQYWQAISRQ
LDSATELGVDIRRMHKVSFEQLVEQSAALEEGDVILFVSFFKDANGDFMEHGDLLTKVTQ
ATTVPVYGANSFMLPYGIVGGIMVDGEHHGKVQAGLLVEALNSGEMPKIISDANQLIFEY
DVAKKRHIDIRQFPQATINNQPPSFWQANRDAVLSSLAIMFIAMVIIGILTKHMNRQKQG
ERALAQSRALFKGVFDQSHQYIALLDYQGRVISANGAFQRLFPEFGNRGFLPLWRWSEWL
SADRLKLHLESLIEGQASRFEVCLLSEQQNEVILDVALKALPDHSHADAQILFEARDISQ
RKLAEQKLQRSEVEYRMLYEQQPVMLLTIDQQSRIQSVNQCTTEWLGFSKRHMLGHKVTD
FYADDSLPPRSLLNGKDRERFGIRRREIRYRTSDGKERWIRESIRSTQVQSQLLLVGEDI
TENRRMEQQLRYQAQHDFLTGLLNRNYFEARLVDVLGTLTENGAVHAMFYIDLDQFRVIN
DTVGHEAGDEALKQTAQVLRELLPIGATLARLGGDEFAVICYDCNEQDALDQGRKILDTL
SELDFYWKNTRLALGCSVGIRMLDKTAGTPQQVHAQADTACYAAKHDGRSRVHLYRPDDQ
ELRRHEREMSFVSKIHDALAEDRFEVYAQPIVSVTSHLKEKLYFEVLVRMRDTQGENVAP
GQFIPAAERYNMAHLIDKRVIEKTLGWFERYPEYVDSVGMVSINLSGRSMSDEGFIQFLI
EALRTSTIPSTSISLEITETAAIGNLSDAIELFKKLKQLGCTIALDDFGSGLSSFGYLKR
LPVDIIKIDGQFVRDIAEDETDYVMVRAIHQLATQMGKKTVAEFVENDAILMRLRSLGVD
YAQGYFFSVPKPMEQLILEAVASEKEATF
>A0A246KDZ6|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MTTQVETTVRSPEAYALAHRAVDAMQEASVWPTPLNFELWLHYLSAPDSPLSQEMARLLA
SGAPFTDTTAEMLAAEFLPRSRLSEEIRDAGAVLNRELAAVAAAIDKARESQADYGDTLS
QAVDRMASAPDTDSLGVIVSSLSDATRRIRRHTSALERRLESSNREVVKLRDHLEQVRRD
AMTDALTNLANRKAFDEQLQRMCDEAESDGTPIGLALIDIDHFKRFNDTWGHQTGDQVLR
YVASVLARIARTPRVAARYGGEEFAVIFPRETAGAVEAALNAAREEIASRSLRRRSTNDD
LGAVTISVGFALRHSGEAASHFLGRADEALYASKRTGRNRVTNAELAASAAA
>A0A1Z3LX39|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MPNPTSAVAAPSCVPEPSLDPQSLERLRALLNANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRRWLIDLFAPNLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDAAAFGLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRAGLMEWSQKTLFRILASGGVDGAGALGASPFGLWIRHRADFLFDGSPHLTRLNATME
RIDTELLPRFTPDAVPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHQ
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGA
>A0A128EZ59|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MRDMELSLSQYKTQLGELLTARSHAAAFNTTRATYLRTRIVALCYIWAALCALWIPVDAL
LLNESVTTLAIFRLKLCAVLLFIGWTTNQRSTLNACRNAMFALVVSLNMFYMLTNHQLGY
PHNIDAFSYCYNLLPFVYVVILTILPLTVKESVCVMLITAASQIYVDIQSGALLSFDTIA
LYWLQTVVGILVIWAQTSKLHMMLRLYRHATLDPLTGVYNRRMLLTLAKRDFENTRTKSR
PYSVLLMDLDRFKRVNDRYGHHAGDIVLQAFTQAVQETQRKSDIFGRFGGEEFILFLPQC
SADNAQLVADRIMTRVRDMGIEVEGVSEPLKVTTSIGISTSLCKSDDLSLILEQADQALF
KAKNGGRDQSSTYDQEEDLIEDGQKRPWLELVN
>A0A6J4F8G2|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MGNAETRLTRDLTIRYVAVLAIIGGLAIASFLGLVRILMDAEAGGAVIGVAAQQRPLVER
VVFAVANLTRPLEPQARLDERAALALALDRLESAHFGLVAGMPEVKGAAPPSAAIKALLF
GPDGRLDHEMRGFVGQARAVLAKADQRLPADDTDAKALSPSRVEPLLVLLDRLVTRYREE
NDKRLRRLFLFHGAALAATLALLILSAAMVFRPMVSRIKDDLAERVKAARKLKESEERLW
RILEESPVGVSVSRRSDGAVVFANSRFVDIINTTRDDLIGHPARDLFRNESQRKAVVEAL
KRDGHIDDAEVQFIRRGGETFWSLLTLRSTFFEEEPVNLAWVYDISAIKAAQAKVRLTAQ
VVESASEAVVITNAANIIEYVNPAFTTITGYESAEVIGRDPGFLSSGRHDADFYQTMWDD
LRATGRWRGEIWNRRKSGEFYAEQLSIVALMSDDGQAVTHYIAIFSDITNRKEDEERIWR
QANYDALTGLPNRSLFTDRLQQAVRQSQRDGSRFALMFLDLDGFKAVNDTLGHAAGDELL
QQAAKRLEDCVRASDTVSRLAGDEFTCIIPGVHGKADVERVAAKILEELAQPFELEAGRA
DVRGSIGIAIFPDDADTGPALVGRADEAMYAVKKSGKNAFRFA
>A0A2H6IP26|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MINLLLKEIAEKKNLSIQGDASLMDLIKLMNANHKGVVIILKNNQPTGILTEKDVVRILH
EGIDLYERADKHSKKTVVSTQGDRTVGYALNLTIDNKIRRVVVTDTNNNFIGLVTQQDLL
KYVEEDFYRLTIKVKHILKESRKLISVSPVDSLSTVLKVMIENNISAIAVLQDNIAVGII
TEKDILQLAADNIPIQNKVGAYMSNPLDTAHPDTPLVEIVEVMNLKNIRRVLIVDKNDLP
LTIITIRDVVKNLEGDYSKFLERKLNNAKQILNLLPEMMIEVVDTGKEQLVVWANNKAIN
MFGNNIIDKPVMNFLPKKNWDYIYITLMTVNKIENIKFKKGDRIYELSGFFLKTDGGGAE
KGRFQLIMRDITEEIRMSTVDTLTNIYNKRFINEFLIKEIERSKRLDNRFSIVICDMDDF
KKINDTLGHLSGDMVLKSFSELIAQMIRSQDVVGRYGGDEFMLILPETDRETALHIIDRL
RDNIEKMEVSVLKNKKAKITASFGIATFPEDGTSSDDLLIASDERLYKAKSLGKNTVAN
>A0A659KSI7|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E2748|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHQTMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A376EGZ1|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MKTPDIPVNEQARLQSLHDSGLLDAAPTERFDRLTRLAKRLFNAPVALISLVDQEQLWFV
SCDGAEPKPIPRRVSFCGHTILSNAPLIIADALGDERFRDNPLVNGPPHIRFYAGCPVRL
PDGATAGSLCIIDTEPREFTESDALLLRDLAAIVEDEFMVLSVATSDELTGLLNRRGFTS
LAGYAFSTHRRRSEPMSLGFIDLDDFKEINDTWGHAAGDEALNAMAMVMKNAFRDSDLLA
RLGGDEFVVLFNDTDDKGAWIAMQYLVEQTDAFNRESGKPWRLGFSWGVVQFDEERQCDL
AGLLKAADDEMYKMKTTHKHAAG
>A0A5B0KGL2|diguanylate cyclase|EC 2.7.7.65|Pseudocitrobacter sp. 73|TrEMBL
MNKDYSTPPRPTFKRTLRRISVTSVFITMTLIWLLLCGASIVTLKQYAQKNLELTGSTMS
HSLEAALVFKDNTAANETLAMLGKQGHFATAEVVSTGNKRFAYWHYNASAERDTLNRLVS
QWLFPLPVTQPITYNGQTIGELRLTARDSLISHFIWLSLGVLTACIVFASAVALLITRHL
HEGVVTALQSITDVVHDVRTNRNFSRRVSAERIDEFHRFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDALTGLPNRAAFRSRIASLMDNPQMKASSALLFLDGDNFKRINDTWGHAA
GDCVLIDAAKRLMEFSGNRHAAYRLGGDEFAVILSGVNSEDEVQRICAALSQQFIRPFDL
RNGHYVPLSLSVGYALTWEHNSVEDLQELADKNMYVMKNQRSKNSL
>A0A2U3K3Y0|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MREDVETVVRSLHPVTRTTSFKTVWGNRWRKKRGDMKDVRHENMVTRPEIDPAVSSWQVL
RRKGVVMERRKATKSLEGQEVMSTGKTWLTIHELRVHQIELEMQIEELRRAQAELDDERE
RYFDLYDLAPVAYCTISEKGLITETNLAATNLLGVVRGALCKQPISQIILKEDQYIYYLF
RKKLNDTGKPQECELRMIKIDETVFWAHLVAIVVHDTDGAQVCRIALTDITERKKKEAEI
FYIGYHDQLTGLFNRRFYEEELKRLDTERNFPLTIVMGDVNGLKLINDSFGHVMGDVLLM
KVAEVITAGCRTDDIIARLGGDEFVMLLPKTNASEAELIIKRIKALAGKEKIEAIDISIA
FGYEVKNNMEIPIQEIFEKAEDHMYRQKLIESEGTRGSTINV
>A0A5W1U9F9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S4FL16|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MIWLRKNRSGHSRPTLGRVLQRANLGLALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFEDRAAAREALMLIASNEEVSEARILDSNDKVLSSWRHPKDGPLHGMEQ
IVAHWALPEPVILPITHEGKEVGKVWLSGHGGSLLRFLLRGLLGMIACLVLSTLCALVLS
RRMLQGIVSSLDDIANVAHAVRRDRTFGLRVPSAPIAELHELSNDFNGLLDELDAWQANL
KQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIEPTEKLAVLFIDGDRFKEVNDSYG
HAAGDAVLTSIAGRIRAQLRESDLVARLGGDEFAVLLAPVHSTEDVLQIADNIIDCMTQP
VILPNDEAVTTSLSIGIALYPEHALTPQGLLHEADDAMYQAKHRYNGGWRLAIQK
>W7PIT3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MKAPATPENETDRLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPGSVPRNISFCGHTILTEAPLVVGDMLQDDRFADNPLVAGEPRVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSVARRRAEPLTLGWLDLDRFKEINDRFGHEEGDKALNAMAQLMRASFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVENYNARRLHPWSLHFSWGLSEFDHNGNDLQ
QWLKDADEKMYAMKQQRQRAR
>A0A238D4A3|diguanylate cyclase|EC 2.7.7.65|Thiomonas delicata|TrEMBL
MNPTEQQCIIDLCRSILATMAHGGDAQAQLDALCRLQEQASPSSLAALMIPTHRGRGLRV
LAAPSLPSRMAEGLDGLSAEAADVFGMHAADDQVPVIVADTSSDPRWLAWRDMARELGIM
ACWSMPIRHDNGQPWGIFALFGTQPSVPNATQLKLLDMGAVAAGLVIHRMRLMENASILD
AALAATTDAVLLANPDGVIEWVNPAFTTMTGFAAEDIIGATPQILHGPLTDPEVKARIRD
ALRQGQSFRGEILYYRKDGSLLWNELNINPVFDARGKVQRFFGIHRDTTAMHAMREQVER
MAYTDPLTALPNRHALESFLSQALLRAKQNKTQVLVGMLDVDDFKPVNDTWGHATGDALL
RALASRLQAAVRETDLVARYGGDEFVVVLVDLQAFDDLPLIMQRIHAAVEQPFSMRDGVQ
IRVGLSMGMTQYPQDDADGEVLLRHADAALYRSKTNKAGREAWWEFWQPVALPAAADARG
MNGS
>A0A1C6CLZ4|diguanylate cyclase|EC 2.7.7.65|uncultured Butyricicoccus sp|TrEMBL
MKIICEKGYHAGNVLRLVAEYLEKRYPDDMILDENMEITLSLKNGENGQSIVLGEKELQL
SHHTADHSEDYYNHDVLTHLYTRCKYEHDLKVFQLANYARLTCIYMDAVGLHEINNHLGH
EAGDHMLRSIADGIRKYFPDDCAYRIGGDEFVLLCPARQPEELAESLAAFRHTIREMGYE
VSVGVSESTDRQTLNETVNRAETAMRHDKMEFYRNNGGIRQMRIIDDKLEQLLIKKQDVT
RFLQAIAPLYRGVYMVNTKQDTCRYIYVPSYFKTMLENNHHAFMSSVREYCRELVHPEYY
DEFAKLLDYSYIEEQIAAHGSLEMTYQIRDGSRVHLKITMADRSSADAHELLWIFLDETQ
>A0A509BYV0|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 6947|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5C6BPK0|diguanylate cyclase|EC 2.7.7.65|Symmachiella macrocystis|TrEMBL
MACSPYIPLQPVETMIDPETIWTSKHLPTLPTVAVELLKLRNDPESGIAEVQALVRNDPA
ISAKILKAVNSTFFGVSSQVTSLERAVGLLGGTYVTSLALSFYLSKHASTTGTLSEYYAR
YWLQSVVQATAAETLGRRAKQRMESELFLSGLLLDLGRLAMLKAIPDEYQAVMTTAATQP
RDLYEIEREQLGFDHMEIGAKLAETWELPETLWTFIRSHHAPVEELETSVDPSANSLERA
LALAACVGDFFCANNLGIAYERLQKRAARDYGMDEQGLGEFLNEVRARIEVVADQFSAQA
NQLEDPAELMAEASEQLANLVMQESVANLHATARHEAAVQAKHDLESQHHELQQQSQYDR
LTTVFNRAYFDEALDAEVGRCVQNAHPLGLIFCDIDQFKQANDTYGHQFGDHILKQVAAA
FLEVLRPDDILARYGGDEFVVLVSNPTLKGLKKLAERIRLRVETEQFEFDGCPVTICVSL
GAALDIPGRNCVDVGDRVIAAADQEMYKAKHDGGNRSQVRSLISESSALLEQLVTNNRFS
RWLVAQHVLDIPVVSRALLQVTGQKAKIGQLAVSCKVLRSVDVQTILAEQECTGERFGEV
ALRLELLNEDQIVDLLILQREDPSALLQAIASQEILSSVELQCALEAYATSRTDVICSEF
FAASPATHQTTDSVPSPSCGIAPTDPR
>A0A730TTG7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5C6BB29|diguanylate cyclase|EC 2.7.7.65|Symmachiella macrocystis|TrEMBL
MNASISSELGNISSSFWIMVLLAVAIAAGTGFAAGIFYARWSDKRSFSRARAGVAQLFQT
VISTIDTAQEVCRLLEKCPGTFLKPNQTEQLVQKRNGLLDAISGLVRRHDPSFDATPRPE
AAPSPAPTPFKVEWTIEPTDPSTGLPGRQAFDENLALLMNAGQESERTSGLLLIKIDKFE
NLRSRLGVGDSDKLVKKMMAVVCRSVRDEDLVCRYSADMLAILLPDTDPETGRTVAGAAR
DSIRAYHFRVEEHGPEIFVTASFGYTACRPLDNPDLAVNRGADALSKSQQRGRNQLHAHD
GQSIKHCLAG
>A0A8J7VGN3|diguanylate cyclase|EC 2.7.7.65|Proteocatella sp|TrEMBL
MGLDNVSLTNYEDIAYHMKKLMHDESYVRYIYGMVESSNRKDPEETWYVIQQMIHISELK
GYSSVQAWGSALAGGFYLDRGNAMAAYDNFLKAYEIFISEDMTEGQAYCCNGIMMVYNHY
GQFENALEWGLRGIDMAEEHDLGELIFSISVNMASIFIDYEMYDQAESLIERFFMSKLYY
NPETVILRNNHKARIRLAMSFEDDALELIERTEAIAVRNKVEGLRHLILLTKADILSSLG
ENTDAEACYRESYEYALKHKNHEKDEILKKWGLHYLRLGRLEESEQKLMQAESLARNSEK
RFMLSKILTHLTELYSLKGDFRKAYGFSKMNNQIMSDILNSQTSEAIYRASEKNTQAAEK
SYKELYESINVLAETGKKITSELDMEKINWILYEEISKLMKVDSVAICTFDEDSGYLDYE
MFIERGEKIPGMKVKIGEKISFAEHCIARNCDILIKNSHREYMKYIPENNISTESQFEIL
PKSLIFCPMIFAGKTTGVVTVQNYEENAFSYTDLSRIRLLAGYISIAVENSRLYREARHS
STHDQLTGVYNRREIHSIGHAISQGLRKTDDPVSVLMLDVDNFKSINDSYGHHTGDAVLK
KIGELIKKVFEGSGYAVRYGGEEFMIIIPGKTHEEVVHLAEKARRIIQETAIEIKSFIVS
ATVSIGVDIEDARSFNLSKSIVRADNALYMAKQGGRNRVVVTQQ
>A0A2X3IXT7|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MLTASVVRHIDGTPLYYIAQIEDINDLKHTEWINKRLMERITLANEAGGIGIWEWDLTND
IISWDKRMFELYDVPPHIKPTYQLWLDRLVKEDLAHSETVIRESLKNRLPFKLEFRIHVK
DGIRHIRSLANRVLNKNGDVERLLGINMDMTEVKQLNEALYQEKERLHITLDSIGEAVIC
TDVDMNVSFMNPVAEKLSGWAQEAAIGQHILAILRITFGDNGPVMENIHSGDFSRSAIEQ
DVVLHCRNGGSYDIHYTITPLTTLDGQSIGSVLVIQDVTESRKMLKQLSYSASHDSLTHL
ANRVSFENHLKRLLQGAIEHRQHHSLVFIDLDRFKAVNDSAGHAAGDALLRELASMMLSM
LRTGDFLARLGGDEFGLLLPDCSTENARYISERIIRSINDYHFMWDGRLHRIGASAGITH
IDGDNAIASEVLSQADIACYASKNNGRGQVTVYEPHRHYMEQGRNTMPLDEQWQVIKDNP
ILMIAMAIAPPRIPESTCFYLLTLRFWGNEGDVINEPAFRSGLADPALHHALDRRVFSEF
FEKYASQVAMKGFGVALPVSGAGIVSDTFINELLEQLSASRMPARLLHLTIQSSDLLTEP
QRAYANLKRLRKAGCRMVLSHVGRDLELFNTLSHHLFDYVMLDPDLILNVHCNLMDEMMV
TIVHGHAQRMMLQTIAGPADMPLVMDTLSGIGIDLIYGETITQPQPLELLLANSYFGIN
>A0A087NBX0|diguanylate cyclase|EC 2.7.7.65|Sphingobium sp. ba1|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFFGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A4V0GKH7|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MANTLVVNTLANLGAIIINIYLLFKISDGFVGQGTFKAKQIAAAIACETVVGMLMMNFSY
VVYETRFDLRFLLYAFSMKYLGWKVTVPTMVNLALGRFLFEVSKSSWLNLYLTFFLMVTL
TFLHAWAKRRFTDKQELFLSITYLIAISFLFGFYLTGDIQKTTLIYIVYGILAYTLAFFL
YSIVNDMQRILALVKIDDLTQLNNFRKFQDDRQRLDTTDVDLSIALIDIDHFKNYNDRYG
HRAGDVILQEIARIFSTYCTASNPVYRIGGEEFAILIQGDAQAAAYLLEKIQKRIRYQEI
ILDAGDSVSITLSIGIAQRQRGELLQQTQERADQALYRAKRSGRDQLCLY
>A0A5E5BU98|diguanylate cyclase|EC 2.7.7.65|Pandoraea bronchicola|TrEMBL
MPDAMSAVPSQPSASSSSASANGSDDALMFDLAPVSLWLEDFSGVKQLFDEWRAQGVTDL
RAHFKTDPAYVSACSQRIRVIKVNRRTLTMFNAPSLDTLVTSLPRVFRDDMLKTHIEELC
QLWNGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEATLERVLISLEDVTELEHARQRVT
MGEEYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVHPEFVERCMNEIHV
LDVNRHTLAMFVAPDKSTLLARLPDVFRDDMRHNFREQLIDLWDNRLFQQREVINYALDG
NEINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYVDE
LNRLERKGPYPVTVIVADLNGLKLVNDQLGHAAGDALLRRAGEVLGKAVAAPQIAARIGG
DEFALLLPSTDATGGAAMIESIRQLVELNNSFYPGTPLSFSMGMATCEAGERLEATVQRA
DLLMYEEKRSHYAGSVNERRAFDGLPSGAGGDA
>A0A554X583|diguanylate cyclase|EC 2.7.7.65|Tepidimonas thermarum|TrEMBL
MGEVHARIQLPIYLVARGARFLKGRLLVTLLRDGLAPELAEAALVTIGDLFDLALELMAE
SYVRDTQRVVRSEEAFRLHALTQNLQVERERQRFLLASWGQEVLFTLHREQSPQVLPALR
NAEFGLWFLHKGSNLFDGAPEVELVHAALQRIDEVLLPRLARANRQDPAHAALLVDLQSE
LDNLQYLVQMLFERHVELESGRDALTRLLNRRFLPAILSREIQLAQRQRLAFALLLLDLD
HFKAVNDRHGHDAGDAVLQQAAGTLLNQVRSSDFVFRYGGEEFLVVLVDVTPEQALQQAD
KIRQRIATHRYVLPNGAELSLTASLGVAPYSGHPDYQYLINQADAALYRAKREGRNRVCL
AAGAT
>A0A447IBQ3|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MVIDNASLLIAIAFSSGSLMIALLIGWMNSRRESYLLFGAGGIGLVVIAMAAMGLRNGAY
DMFIQLVPFVLLLIGFALIYAGSRIFRDEAASTIPALVIGMVAVITTAVPIIVGLSGIGT
IMLNIGGAVLMLLCGREYWRSRKEARGALIVNAVLYTLTAISFACCALVLLLEGRWVLDG
PPNNWAEDFNSIMSLVGLTGIGAITLTLHHARNARHHRMEAHTDALTGVLNRRALFDIYP
EGHIATGLAVLMFDLDHFKQINDRLGHAAGDHVLQQFADVMREELRAADTIARLGGEEFC
VIMRDMDGERAKAIAERIRTRFAGLNLSRGQDGQVATVSAGLAVGGQDEPFSSVLSRADA
ALYKAKSAGRNQVHIAALRLVA
>A0A1A8TEW5|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MIPSVIYYSKTVTPWKESLKNLLSRVPDQFSWQGIESLQETPVSGLIIMHQSDLLAEDYP
YIAARKVLILLDKWDFSLALKWIMQGVNDSAAYDDLTRIATWIVSEKARISWHNNNLAQQ
ENILQTVLDAIPVPIFYKDEFHIYRGCNQAFSEFIGLPKESVVNHSVYDIAPKELADIYY
QADQALLDSGGTQVYEAAVKNAQGEQFEIEFNKAVFFKENGDKAGQVGAMLDITERNRLM
RQLDQASRTDPLTGVGNRREFNLAVSITLQKAQNAYGSTSLLTIDIDHFKSINDRFGHSC
GDEALKFLVSCIHEAIPATGQVFRIGGEEFYVLLPKLDLAQAKQVAERVRQHIPEQVMTL
KSEPVQMTVSIGVIQLASENMLEESFKRVDQALYEAKMTGRNRVCLAYYD
>A0A0Q0HWW2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MHQNTGHGISSLSNTQLEEVIAEIEQAIKWHQSWYRNLLRCLIADIPADEQDLADNAHNL
CRFGQWFNKLPEQTINLHPYFSEIACAHQKMHQGAKVLLSLKESKSVIPANLLDQFHADL
DSLHEFFETLIDEFSELLHTRDPLTGASNRTNLVENLQKEHELCKRKSLSCALVMIDLDH
FKQVNDEFGHAAGDKVLIALVKCIKSHLREYDQLYRYGGEEFLVCLPQTELEGAKSFSER
LRAGVEALKIEIGNDQHINVTGSFGVALINAEDDIEKAIERADQAMYQAKKSGRNRVSVA
>A0A0Q0JCG4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MQQQHDVLNKKLKQAIDARTVVEDARKHQVEVLSQFAAKLSLSCKGLDIELDNRLAKFRN
ALKKGVKFELLTPFIDDVLGLLKQQETKQMALQRELNESVTDAGKQLQKVRGLPEDARRS
LRYLLDHELNNIQSNHDFVPLLSKLILIYHQALQAKLATTNTAEAQIRPELATQLLSLAN
DLVLEDESAEQIKTIKSKITQNDSVDDLLDSALNIISIVTRNMSKERQSAQSFLISLNQT
IEDLHHSIVSTSKHSESLSAEYDTLNKQIESKIKNLHTQTQQATSISSLKELVEEELKSL
SDDLIAKEKLEQTERENLLASFNDINSRISHLETKLSTYKQRLNEQRFKSLLDGLTKLPN
RAAFDERFNHEFNLFNVQESDITFVVIDVDHFKSINDQYGHSAGDKTLQVIAKALQKSIR
KSDFIARYGGEEFVLLMSGMSIENATVPLEKLRKTIQGIPFKFKNKQVEITISLGATQLK
KGDTPLIAFDRADEALYKAKNEGRNRVCISK
>A0A0P9GKK1|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MYQDVAVDHLPVITSSQELVGFNFSPDIVWVFDLDRHGFWWGNNHALNFWGLSNVQQLID
KDLSADTEGARKRTEQTFVKAAQEGLTNDPWTTYPNGEPKVMLMRHVAVLLGPEKHRGII
AFISEQMDATSQPENLLFAEAMRYTTVAVSCYDMQGKRLFENPAFTEWYSTIKQDYISDF
EQRFTNLNEGKERLIDSQQHRGGCQEHIMLTKLGERRHNVDIRISRHPLSGDYVFLVTEY
DITELHDTIKELKHTRNELKKIAHYDPLSKLPSVWLTKERLASALKQAKRNESLLAVMFI
DLDGFKQVNDTYGHSSGDELLKQVADRLKNTFRESDTVGRLGGDEFLICLPNLANKQDAV
RLAEKAINEIAKDYQIKDVDGQSNKVNISASLGIAYSPDSSDTLEALIRSADEKMYQAKR
AGKNRFSY
>A0A0P9HYA8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-9|TrEMBL
MLEKRNNKPNLNVTLNKGSKHTKSSEFPKDIDETTLIDYLKLSTEYSADEVFWMEPDSTI
IYVNQSACLKLGYKCHELIGMKVWEWDPLFPKEVWPTFWEELKSLKSVDFETQHKGKDGV
VFPVRIKGHYINVHNKELLFAYVTDITRIKHHEAELESYNKRLEEEVNKKTRQLKAEKDS
VQKHAKNLERLIKQLNETVEKNNYLQQQLYNEAHTDALTGLYNRRHLDEICAKEVSRADR
YHTPLSAIMIDIDHFKLVNDMLGHQVGDEVLKELANLLSKRVRESDVLARWGGEEFIILL
PNTATAECESIAEELRELVACHEFGDVGQIKVSIGVTKHNNDEPSTMLIHNVDLALYQAK
NKGRNRVETYTYGVE
>A0A375FQX8|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MRPRLSALLDHLWEQAVRTPQRFVVLSFAAAAVLLLVISAHGLVVLRDHEVQTLQQTQQL
QVAGISSVLNVETERLRSVRNFAQHLIRLQMGPHAVEADPPLQAAYAHRNDDLWQLPAPE
GDAVLLGVGPRMLEGMDSFYRRDEDLLPGLYVARGISHLLSAEPVNPLVTRKLMYVSSNG
FFVAYPPVPPARTAAVLRRVDDAGFLREHLPHNNPDRTLRWQMMPAGDGSGDVYLTVSLP
VYLHAQFRGVAISGISQRSLDAYLTNTTRKGVRSFLIDIDGRLVGASTRDVRSVEKFAAA
VPSASGEATPHEMFRRGSGTLHLADGSRLMFQRIGSTNLMLVDYFSATDLLLRTASHLSV
VLAASALSLAVLLWVTLQGFRKLFSHYQARGEALRELAETDALTGLANRRVFEARFAVEH
SHSLREKTPMSMLMIDIDRFKRINDNWGHASGDRVLKTLADVMRATVRAIDVPARIGGEE
FAVLLPRTSIEEATQTAERLRKILGQTVCGPAADAADMGDIRFTVSIGVSDLGADGTDNL
DTMLMVADRRLYAAKNAGRNRVVSDDRVPEPAGDSAPAPAPTA
>A0A6L5EFT9|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MDKDHSPTTRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQKNLELTAATMT
HSLEAALVFTDDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNAQENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASSIAILLTRHL
HRGVVEALQNITDVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFTRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRTERSIK
>A0A5K6CLB1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii (strain AB307-0294)|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SIWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAVCTYLSMTGVISYAPLF
NFKTMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIARCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A1C3J0R0|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MRILECSPYPLKGVGIILLDIDHFKSVNDLHGHNEGDRVICAVAKVLKQFANENRLIARY
GGEEFIFVTFDCNEYQLYELSEELRRSVEKIEGLVLPVTVSVGCRYANALFHIEGTIDQA
DKALYQAKKNGRNNTQVYRESQYRIVCH
>A0A1C3IPH0|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MANVHPRLIKNVVDQTPRAMIAMLIVSIAYGAMFFKFIPMDILCIWFLGQVLLAWSRLYN
AKQFMIHLNCFNQKGLNRNERIFVILNVFQAITWTISSLLIMKYAPQPFEFVSFVLIIGI
ITAAALSMSSLYRAYIVFFFSMLIPQIIIMLYYGEHQHISLVIFTIIYIPATILLSKSML
NNRMSSILAHEEIERSAEKFKQLSTVDNLTNIYNRRYFFEMSQSLLTTDREQKSISMLMI
DVDNFKKINDNYGHQAGDYVLTCLAKDIECLMRKSDLFARIGGEEFAILLDDTSFQDAKS
IAGRIIKIVEESEVVYNQRLIDVTVSIGISVLNNDITDIEELYACADKHLYQAKARGRNQ
YYPSL
>A0A378ZVS2|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MSATGRSRVWLLTGLITLCVMLLAVMADSYNLPDLEPEHRFWSLAIALVMPIVTTGPFCF
VVFNRLRQAALREKELEALATRDSLTSVLNRGAFTMLVSAYLDDARRQEQTSEGALLIVD
ADHFKSINDTFGHQTGDTVLKVIARAISSPLRKADLVGRVGGEEFCVFLPGISADDARSI
AEAIRCSVREAAQLLQAPVPAVSVSVGGVAFREPVAYDRLYEVADLLLYKAKNGGRDRIE
FQHFGVLA
>A0A7D6PR15|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPIAFSSTQLGVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHEKLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7Z3R4P4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRKTAEIDSILMELNHSIDAHYKWLVKMFHCVVSSDVTQADISGKNSHCACQFGQWLTP
RLVQDDADYSYLSKINAAHEKMHLLGKDLLSVIVEERSQSWHFDSFQDALLAFTSAVMDY
KIHLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAQPLNLYLLLLDIDRFKYVNDTYGHLV
GDVVLRSLASNLLSWTRYDEIAYRYGGEEFIILIRTKTDEQASLAGLRLCHLIEQKKIPY
PQGEIDITVTAGITQVRPGETLDTALGRADRAMYEGKQTGRNRCMFMDEHEQITRVGAKE
WVTTHA
>A0A2U3AC76|diguanylate cyclase|EC 2.7.7.65|Kurthia zopfii|TrEMBL
MKINRIKLQYLIIGVALLAFMLTSVVSIWSGYKLNKDNLGESALETNRVYAQKLADTANN
YLQEQIMMLSANVPEIAEQMSNEEVLKKKADLIRNQTDAFNSIAIVNDQAVVQATSPQTL
DLVGVKLTSNAMKEAIKKKKPMISQPYESVSGRLIIFISVPLFSKTNDYLGLIGGTIYLK
EDNVLSELLGVHPYSDHSTVYVAAKDGTIVYDENKENIGEDFSKNKIIAKALEAHKTGVM
KGVNNAGEQSFAGYSYIKESNWTVIAQRPADAVEAPAGKMVQKMLNIAIPLLFVSLIIVI
FAAYKIAKPLQRLAELTESSKAKDEEKNFRTVPAWYYEAIQLKESLIISFGALHNRVHDL
TDQSRTDALTGLFNRRTLDEVMNRWTEEQKHFSLILFDVDHFKKVNDTYGHDVGDEVLKY
IAITMEQHADVSDLCFRFGGEEFVILLPKTDAEGAFNFAEKLRKSFEENNSPTGKPITIS
AGIAECPKNANDYGTLIKKADQSLYYSKENGRNQVKITE
>A0A7D6TKV1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSHYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDSTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVYMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMWRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFESHLKQLLHSVHDTHQHHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFQAGLVDPTLSQALDRRVFGEFFQNAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPASVIKTNPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPVIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A7W3E6I4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVDVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A7W6H554|diguanylate cyclase|EC 2.7.7.65|Aureimonas pseudogalii|TrEMBL
MTAKILVVDDQPINLRLMQARLRDEYFEVILATSGAEAIEICRRETVDLVLLDVMMPEMD
GYEVCRRLKADPACRHIPVVLITALDDMRNRITGLEAGADDFLTKPVRDLPLFSRIRSLT
RLKILSDEMRTRAETTMRVLAGNEADAVAESGTGGSVLVVVDSPAEGERLSRILRSEHTV
RVHVGPVADLEAAAIEPTDLLAIDLQAESFDPLRLCSLVRSNEATRPLPILVLASDGRDE
TRIAKALELGANDYILRPVDRNELLARARTQVKRRRYDESLRRSLQQTIELATVDALTGL
SNRRFFESHLTASIARARTDAKDLSLLIADIDHFKQINDGWGHAVGDGVLRDVAARTRDS
LRACDLACRIGGEEFVVVMPDADSEAAAAIAERLRRVVADQPFPIGGEMISVTISVGFST
LIADDTDATLTKRADQALYEAKRLGRNRVVLRAA
>A0A514ERH9|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MLLKELMIFDLLTTPVWVVHPFKEAVVYCNQASRTLSGEMSLDDMRKGPLSTCPERSLQN
YLYYFKNIAEVFEVWTIQTTEGPRPVYCKTTLIKSAEYDTLILFEAVKILQQNDAVKAHP
AHHYKRRSNRFFARFFMTSSAPMLLIDPEQDGRIVDANIAALRFYNYTADEMRTRHTWQI
NILGKDVLPVMHGVASLPGGHKPLNFTHILSDGSIRYVQTYAGPVVLNHTRLMLCIIHDV
TEEVHLKAELEFAATHDPLTGLLNRREFYRIVDSSLSHAEGFCLLLVDVDNFKAINDNYG
HQKGDEVLQAISRILESTAKIEDKIYRWGGEEFLLFLPGASIAPALAMAEAIRHAVSCYH
TPEYTGTVTVSIGVAEHQEGEEINQLFNRVDKALYAAKKEGRNQVKLYLVEKY
>A0A5I0YN98|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Oslo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2T0ARE7|diguanylate cyclase|EC 2.7.7.65|Clostridium thermopalmarium DSM 5974|TrEMBL
MGKCDGELKDKYKEEFLKLKDEFETYQSFAEATIQMITEKNIKLEKKLDSIINIVEISKY
INSYLSDKNLIPMINDMIIGILGATYSSIYIMENGCLVVKATNVQNKNYNFCEDEYKDLL
NGKAFIINSKETIFLKETSKSDIHSVIGVPIYLGEKFMGYILVEHGLNNYFGYEHIKFIS
NIANQIAIALENNALYNRIREMAIRDPLLGIYNRKYFFETVEDILSKNPMEIVAFVMMDL
DNFKEVNDKYGHQFGDKTLIQTTNIILHNIDDKNDLIARYGGEEIIICIRKVTDMEEVYK
KIDNIRIKISENVVRYKDIEKKITASFGISYYPIDGTNINEMISVADSRLYAAKKKGKNK
VINK
>A0A0F3R9W4|diguanylate cyclase|EC 2.7.7.65|Rickettsia endosymbiont of Ixodes pacificus|TrEMBL
MTTILVVDDIETNIKLLTAKLLKEYYTVLTANSGKEALAILKKEKIDIILLDVMMPEMDG
FEVCKTIKTDPETTHIPVVMVTALSDIDDRVKGLEAGADEFLTKPINDTALFVRLKSLSR
MKSLIDELKLRNSTNALLGVTNIEMHDIFADKKILLINDDVVQAKNIKQMLLKITQNVKV
ISNSDELDIINEYTPDLVIISSMLENDDPLRISVILRGKAEISGVVIISQIDEDGMPLVV
KGIELGINDYFVYPIEESELLARIRTQLRRKQYQDNLRNDLEQSVNLAAKDGLTGLFNRR
YFDIHLKQMIEKANKESIKLYLLMCDIDNFKHVNDTYGHQAGDKVLTIVSRILKNTLRVT
DLIARFGGEEFTILLTDIDISKAIETAERVRVKIEYMDFHIEDQIEPLKKTISIGVTEYK
KEESIESFIERADKAMYEAKTTGKNKVVKL
>A0A2K9K5I2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MTDNALMLEQKLKQAIEARKTLEDARKQQVELLTQFAAKLSLACKGQDVSLDNQLAKFRI
ALNKGVDFELLVPFIDGISEPLKSQEVTNSNNQKALQTAIQQSGKLLQKLKGLPDESRRK
LRHLLDVELEDINSTNAYIPALESLVSIYHTVLQSKVEITEETSHSHHPELAAELQALIN
ELIFEDEVIEKVKEIRASVAENNSLDNLYSAATEIIKIIAQTIAKERQSAQGFLVSLNQT
LEELHRSIVETTARSKSTSKELQSLNNKIELKIQNLNQQTQNASSITELKALVDNELKLL
SADLIEREKLEKNEREALLDSFDAINNRINTLESKVSNYKKRLSEQKFKSLLDSLTKLPN
RAAFDERLTHEMHLFEINDSDVTLVVIDVDHFKSINDRYGHSAGDKTLQVIARALKKSIR
KSDFIARYGGEEFVLLMPGMPLTHAQKPLEKVRQVIKSIPFKFKEKEVEITISLGATQFV
KGDTALSAFDRADAALYEAKNSGRDRLCFK
>A0A0Q0G588|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MHTMRFFILPIIITFLSLGLLEHFQTHWIDWQDTLHFAPYWLLAASSLICLQFNRSRLFY
IGLMLLTFYALQSNRLFLSPVIHQFLPLFGTLVITLFCFIKDRGVISVHSFYRIGGIVLC
GLIAYCWVYLTGQYSATIGQFQQSIGLTIEQSPLYLLPIYPLAIILLCKLSWKSNLAQTS
LGICLLLWLGYFLVPTNLPLSVLFSCIAISFLITVLFDSYFLAYRDELTGLPSRRALFNL
SLALGRKYTVAMVDIDHFKSFNDTYGHDVGDDVLKLVAVKLSKVTGGGKTFRYGGEEFTI
VFPRKDIEQVYSHLDDVRQSIEDYDIVLRDENRKNSSKKQRNKAPVKKKTVNVTVSIGCA
EHKPEHSFEQSMKLADKALYRAKDRGRNQVRF
>A0A173R3Z7|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MYNKKKKIKHKTLKIFCLLIGMIVTAVFLEAGILYIVNSKNVYKTSKVLLDQTIEIVEKN
KQSEVGTVVADIPVYKGIALYVADKETGRIYGATDASKIGVKLDDMGFRKQRKTVAKEKI
VSGIIRVDGKKNYYILKKTQKYIVGVTYWIAVDNKSNLIAILIMVVYLSIAAIGILFMVL
RLSKVKKKNKEQSVMISSISEMSNIDKMTGCFNRKAYDEDISEIRMDSQFIYVSMDVNGL
KIINDRQGHAAGDELICVAASCMKCRFNKYGKVYRMGGDEFAAILFVKREQFEWIRRQFD
GDIKYWSCNRIKELSISYGYVSSSECQWDSMKEISDVADIRMYEEKAMYYKKNGVDRQGQ
PASYVALYRLYTQILRINLEKDRYKIINWEETKNKKKQDSIGALSEWFHNFEDIRLIHSD
DLVKYLRKTKIEYLKKQFANKKKFVTITYRRKEGDGYKRITLEIIPENENSQNTYEGFLY
VKE
>A0A8E1ZQX7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SwsAc2|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFSRKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A608K5T2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTRGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A060UT44|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus ferrivorans|TrEMBL
MRHVVSPELRFLDGFLDTHMHPIKRTKWTINAIFFAAAMVVSGVVLFNAMTIRIAAVRTD
LHNKALVAGKTVADGVAEQINTHFNVAPNRLLGTFAYARRDHTWVVTMRKRVKTKKRHVL
GFVGAPFILSNLDSIRISPLIQAVVLSLPDGKTVSIWKGGHWNPPGTPLSSPVGEITLPV
PGIPLMVKAQWDAATLNHLFWEDERPFLAAAFLLLLIIAAMYRGTQIAYRNLIRLQEYQA
VALQVQQSLIKLQSPEEMYRLAVESIVQKTNAIGAYIAVPDAHTEYLQVTAVCADEPALE
QSLTQLRISKDIAKTTPFGPPVHQALAEIQKTVPALQRIRRVMAYPVFTSDFVAPSAILV
IGSDDPRHFNAALQNLQAQMVQSLGAALTLIRHQQQLMALSEKNEALVKNASDGIHVLDK
NGVLLEASYQFCDMLGYVGDEMIGMHVAQWYVEENAGQLRESIAQQFATQEPLRFEARYR
RKDGTIIDVEINGLPIQIQGQWVLFDSARAITERKVLEASLQQSLEHQQQLTNFNILLSE
VNQAIARADCESVLLHDICMLAVQHTNMRLVWVGAPDAQGTFQILAQAGETAYLEGILIS
SRDDLPEGLGPVGRAWRAQEKIVGSAFSMGSDMAPWQERAARFGIEASATLPLYRGGELW
ALLSFYWGKKSRFDEDAQNILEELGRDIGFGLDRLDLARQEHESSAFNAALLNSLTVGVN
VVRYPERVVERANARILEIYGISSMEEMVGHSAYEFHPDMETFQKVGEFSISVLAQGHGI
LRDVPYQRRDGTVIYIDLSGQKMRTRGGEPERIIWTHVDATERHWNEETIRQLNASQESL
LANTITGINLVQYPERIIREVNQGFLAILGYQNAQDVLGHSTHEIYPDSENNQKMAQLAQ
EILARGGASLKDVAVKRRDGRMIYVDVSGQRLMTDPEHPLIVWTSIDVTERHQLMEDLSR
QSSTDLLTALPNRRALDMEMDRAIARANRNQTLLAVCMVDLDSFKPVNDSYGHEAGDTVL
VALGKRLKASLRKSDFVARLGGDEFVLLIEDLDHMNSLAPIMNKIGDIIREPIPLEDGQM
VQVGLSMGVALYPFVDGDNSDMLFRLADQALYESKANKADRLQFWTIYGQETSKHFNRYQ
KLFRENGLRVFYQPVLDNRSRRIVGMEALARLQDTDGRIIAPMEFLPYFKEDDLYDLTWQ
VFSQTLADIQRIDAEGPEDLRLWASVNLHPSSLNERCLAYLQVALAENPINPERITFEIL
EGGEFLNTEDAVEQLEDLRALGVRIALDDVGSAYSSLLRLKILPVDEIKLDQGFVRTLEQ
RPEDLYFVIMMQHLAENFGVSLVVEGVETDDILDALTVLDVEIFQGYAIARPLPLEALLQ
FLKHSPPKTRCEHPTSLLGLYAELITHNSVFKNAIRQDPQLASYMPLANASTCHITKDLR
RLGIAEGSTIDLLHRKYHQAMVAMNLRIIAAPKENDWSLVQTAERHLLDAVIAEYKKIKG
N
>A0A5Y7AMS6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Infantis str. CFSAN000522|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALAWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6L5C4W0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MLLPGKPIKPGTTADTLHGPDTALQERELLRDLARQAEQELTAVQVASMDELTLLPNRHG
FQALAQMGLDACLRMGKPATLLFFDLDNFKHINYLYGRAEGDDALKTFADVLRIAFRESD
VIGRMGSDEFAALLTGAHAVEIPAIRARLEEMLDERNATVHRGYDIRFSVTQIEFHPALH
QTAEGLLAAIGEQVNGHAFGHS
>A0A5Y9YA17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFNSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLHLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A749Z7C7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVILRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A378EA63|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMDNVPMEYGKQQASLSGWENSAIFNIV
SENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQMGEITKLIGQVDALITEWRTAGCWL
>A0A613R4Y2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A750P764|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMDDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3F3IDF2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYEFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5T3M8S2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTAILELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A174QQJ1|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MQTNKKNKNIIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREVKLE
ITGNQNDELIKYLDDILLGLRYQDGHYNLVKLNDEEYQGKLKIQSDYWDKLKTEIEAVRN
KGYENTDIVNMSEIYFTMADETVSAAESYSEKIAIKIRTIELLSALDMLILVILVIMQTL
KAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITGSTACIMFDLNNLKTVNDT
MGHSAGDQLILNFSKFLRSVIPEKDFVGRYGGDEFIAVIYHTNEAEIKEILKGLYREKDR
LNSYENQIPIDYACGWALSSDNMSCTMQMLLDDADANMYKNKQLCKKYNWHS
>A0A174MML9|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MNKQDQMTMQEAERKMESLREVFQVVRLVDGKMLMDREKRINAGDLSETCQCYSFWKKDK
ECENCSSLLALKEQTQKIKFEFLDLQVFQVISRYVEIDGRPYVMEMIQNLDESIQIDQEG
YDKLISKLSGYNEKLYTDVLTGIYNRRFFEEKIKNMEDEAGIAVIDLDDFKLHNDTYGHS
AGDAALITTANIIKKYIRKTDILIRYGGDEFLLILPSIKKHIFEDKLKLIREKIHDTLCR
SMRKCSFRSASAELYSAKAILKMLLPVLTDRCI
>A0A5B9Q589|diguanylate cyclase|EC 2.7.7.65|Bythopirellula goksoeyrii|TrEMBL
MFHLLPKNITAKYKQSVLIEYGLLLAVGMVTLVMWKYERHDPVLLHLYYVPVVLTGFILG
SYRARFMALFCILSATVVLIPGTIRPLTQSLPDNLVPTYCVWTATIMLVAILVGKLSDGW
RDALETLRKEHQKDVLTDPLTGIANRRAYEFELNRRVNQRERDGTPVTLVILDIDQFKKL
NDRFGHPAGDAVLKGVADVLQATIRKSDLAARHGGEEFSIILPGISLSEAKDVAERIRTL
IESRRFTYNELTLRTTVSIGFAQFQPDDDLDSLTRRADAALYSAKEAGRNCVYFHDGRSC
RHQGAGFVASPDSLVSKGHLSTTFLEAYADETTGLPGKRVLLEELRRRAAERSRYGTELV
LALVRVNYFALTPISQIHARKSLLAKTASLVCSQLRETDLVVRYGNDTFGVLMPSTTLQG
ASVPLERICAQATIYCDSQYPGLSYSVSIGVAEVSRNEKPNSTISNADVALQIAVARVIG
CVEYFQAAGTDVLTASTSTTNEHREEFASGFTSETLPKV
>A0A5C6E2I0|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MSCAPKIRDKKTIDVANAAEYARQALGYIGKFQTPPTPNVYEVWYRYAEGNCPPINEQLS
YAIHDAKSADYELLNQLHEQFLAWNDRAAITGDLGEQLSLTIEDVESILSEQRSTHDDFQ
DATGKMSDRVETQQLAPETLKMCIDSILASNRAIQSQIDKMAIGLDESRSQIRYLRDRYL
ESQKQIMKDPLTGVGNRLFFETMVNDAINHRQQSNRHSILLLIDLDKFKYVNDTFGHSTG
DQVLKFVSTHLERLAVDASVARYGGDEFAVFLSTEQPNGGVEQAETICEFFASNEMEKRE
TGAYSGKLTISVGGSMLRESDTGSTWFERADRLLYSAKNSGRNRAMVERKIK
>H1WFG3|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MICASSKEWVTLPPDEINSYSQIPTQPELQDSEDINSRDCFCSVSEPRAVKNRIKQCLGI
AKRNTLPVSLALMGIEGLDLCLQQQGYQKTDQVLMELIQEIQDHLRECDWVAYWGNNQFV
MVIFSDPQGAKIALKRIWQAFKSRKMNLDDAVITCSARIGFTQVHHNEHMNACLERMESA
LYKAKTTNKALAFLA
>A0A7D4SXZ3|diguanylate cyclase|EC 2.7.7.65|Yersinia mollaretii (strain ATCC 43969 / DSM 18520 / CIP 103324 / CNY 7263 / WAIP 204)|TrEMBL
MDLSAAEKPAPDNKTILHITIVSVVVFLLALFCIQLSEQSENLAPLWFPTAVLMVALFHH
PSRYWSWQLLSAGICIVAANFILYGVSWFPLPLTAINLAESTVGAWLLRRFLQPKDPLNN
LFSWLKFSICTVIVVPLLSGLAAAWYLSPQNGSFTQVLTVWFMSEAIGMLALGPVGLLYR
RGYFNIATKSKALFDMMGMMILSLAACYIGLIYLPFPFTFVIMALIWTAIRLPRFETFTV
CFLATLLIAMMINFNLFTLQGDTTLSVQAFSFIPLLMVLIPPHAMAMVMHSFRMEKEHII
ESENRFRNAMEYSAIGMALVSPEGKWMQVNQALCKLLDYSQETLLTLTFQQITHPEDLSA
DLKLLDDLYHDRIPSYSMEKRYIRSDGEVVWALLVVSVVRDHQQQPLYYISQVEDINDLK
KTEIINRRLMERITLANEAGGIGIWELDLRKQLISWDKRMYELFHVPLHTPVDDNVWRQY
IHPEDLNRVNREYSAALNQRQPYRLEFRLLLPNGEIVHLRNQANMVCDKSGNILRVIGTT
LDMTEIRNLTEALHEEKERLHITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALG
QPVNHIIKLTHGVDGPEIENPIEHCLNHRPYSSLNESIVLHHRDGQYYDIQESVAPLKTL
EGGVVGAVMVFQDVGESRAMMRKLSHSALHDNLTSLPNRANFENKLKAAIQVSVELNQQH
ALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHLRNSDCVARLGGDEFGLLMLNCTL
PHAKAITQSLVSMINGYHFYWEDKLYRIGASAGVTQISSSNNQRSEIMAQADIACYTAKH
SGRGQVFLYQPRQKQLLARQHELLSKEDVENILSESQLTLQLTPTAPPKTPLSVCFYQVS
FVVTRPQNMNVSQAAFQEAALLYGLLPQMDGWVCEQLLVAHAEAINRKGLALAIPLSEIA
LLKEDFRQSLLSLVQQTPLPPQSLYWMVDESTLLQYPFAIGNFLAKLQEQGCQLIVKEFG
HNLNDFELLAEHTINYLKFNSDLIAHIHINQMDEVLVSIINGTAQRANIATLAGPAELPP
TLSKLIAIGVDLADGETIGRTQPLSEVLHSGYFAAK
>A0A377FS43|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MPFTALLLNASVAFKGFYLISKLYHSDRFGSFRSRGFLIGLLTGGLGLFLMVNAVQANDE
VRVDLRYLPLVLLAFYGARFPLLIATVIIASTRFLFGLTDQAIVAFIATFVVGVGMWWIH
RHVRRLLLQSMLLHVWALFITSVSILINLGWNSAYVEIVLTFWIVGLLVGTLASLLAIDL
EQMTRRSKEYKHSAERDHLTGLFNRRMWEERTTSLVSESRTYNVLALDIDHFKRVNDTYG
HPNGDLVLKRFAELLKIETRSHDVVARIGGEEFIILIYDLSPEKVAKVSERIRKRIEAEA
FTLSDGTSIQVSVSIGIAHGSALPVESMSDVADTALYQAKDNGRNQTVLLHADARMLVPN
>A0A290HL74|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MASLLTSNEKAWLLAHPTINVGMDSEYAPYEWVNQNGDYVGMAVDYLHLLEQKLGIHFKI
AKGKSWSEVVELAKKGEIDVLTSIVQTPERLQYFLFSEPYRDTQTMIVDNGEGKFIGNLE
HLSGKRVTVEKGYFTQELLTTKYPKIELVLANNILEALTFVMEGKADAYVGDMSAINYAI
KNNGLAKLRISGQTEFSSQHRFAFSKNNPMLAAIITKAMASISAEESDTIFNRWIGMRIE
QGIHTKTLVKYSIGLACLFILFGYWYYRLHCEIKHRQAAEMREHHRNAVLEMIAKMLPLS
NILESIVLNVEEQNPKMLCSILLLDSESKFFSQVIAPRLPTFYNEAIQGISIGLGVGSCG
SAAYLKKRVIAENIDTHVYWQPYKEIALRAGLQSCWSEPILSSSGDILGTFAIYHTCPQT
PMKTDIAIIEQSANLASIAIEKSISAIKLRESEELYRRLTEEVTDVIWKVDRDLKITYIS
PADEKFRGYRADEVIGHHVFEMFTPESINIISEKIKQRLEAQQKGMNTEEFVTYEIQHRC
KDGRLIWGEIISKPEYNASGEIIGFHGITREITERKAMQDRVQQLAFYDSLTKLPNRILL
SERLSYMLAEMKRIQKYSALFFLDLDNFKSLNDTYGHSIGDLLLCQVAQRLQKCVREVDT
VARFGGDEFVVILNTLHEDNQVSVEQAHRIAEKILQSVSALYVLNVSHDKSEEKLVEHKC
TASIGVLVFKSAEKTPDDLLKQADAAMYKAKEAGKNKISFYEAPF
>A0A5M9J2U1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MFSVLKPHRWKLSLLLIAANLGLILHLACGELKSVSEWVWLDIFGEGGSALLALVWLGLV
LKSRPAGRVTNYLALGLSCIFFSWWIDSLDEFIRLPDSITWDHWLESGPMPVGMILLTIG
IYHWHREQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLADSLQDSREQQQPLSL
LALDLDNFAAINQAYGHAEGDAVLQALSHLLLLNLRRQDLLCRLAGDRFVVLLPNTGERQ
AKELALELQQAVRGLAHKTRQQGERLQLAATTAVVMALEEPPQDLLKRLNLALARAKQPL
AKSA
>A0A084XWY4|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MPSFANPSEIARETLRLLASRRISPSPENYRDIYNEIAGTSGNLAENFPKRELQVLQTAL
PRETAVQQKLVKRFEQAFKGKNWDELRDGMADLVKQLANEHELPWSELFRDFLCQWENKQ
AGLTVARKREALERVLAAATGNSELLFGRLQGLVKSWSSSGPADGEIPLIEPGAIAGTEV
SLPLVGEVGADSLTRASESSSELRDIFAYTLEVIIATQLSDEPELAADARMLVHKTRSAT
SSSALQGLLAGVKRFAFRLEILAEDRTELRAGLLNLLQLLIENVGELVTEDRWLAGQIEI
VRDIVSNPLSIRAIGDAEGRLKEVIFKQSQLKRSLNEAKESLKQMLAGFVDHLAEFADST
SDYHDKLELCAHRISMAEDITQLEDVLAEVIHETRIIQLNAQRSRDDLRTAKRRVSEAET
RIGELQLELDRASMLVRHDQLTGTLNRRGLDEAFEKEVGRAQRRQSTLCVALLDIDNFKK
LNDTLGHDAGDAALIHLATVIRETMRPQDTVARFGGEEFIIILPDTSVEDAQTAIVRLQR
ELTRRIFLHNNDRRLITFSAGVTHLQPGDTQGSVTKRADEAMYAAKQAGKNRVMIG
>A0A084Y2J4|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MDEVFRQSIVDRRLYRYAERESKVEEEIVTRAELRGDQAGLREEVKKAGAVEFVYQLALP
EGKRIWLKDQANIEVFVEDQICLSIGCLTEVTKEMEQKDLLEKIGYFDELTKLPKRTILQ
RILEINIGNLRRGHVTDFVFLLLDIDHFKAVNDMHGHQAGDQILVGFAEVMRATKRHEDE
IGRYGGEEFYGFSIGGLNNGIQFAERLRQAVAGSEFVFDRERIPVTVSVGLVAASQLAMD
GEISAEELVRVADRRLYLAKEKGRNRVIFRG
>A0A2P8AMY1|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MH33|TrEMBL
MPDPMTVASGISAVGALASAWQLRRRAVRAEAEIELLQAELAAERHAASHDPLTGLPNRR
AFFRLAATLLTDAAGKPLVAIVLDLDDFKQVNDRYGHAAGDQVLVSVAQRLAAFAGDNLV
ARLGGDEFAGLLVSPMVDRRWIEHATRRLCEALAAPIPLGARSIRVTASVGLAPVHGPTQ
LTDALCRADAAMYQAKTVGAARAARQLVAER
>A0A8G0CWJ9|diguanylate cyclase|EC 2.7.7.65|Devosia salina|TrEMBL
MRQIGRRIADTLSLRVLLFVLLGFAVVAVPAYFAFNWVVSSTVIQLGTLFAEKQVLYDRH
RGLQALLREVSLAETLAGSQAIRDWALDEEDETLRRRGIAELEHYRQSFVDHSYFFVIDR
SGNYYYNDAGNAYAGDQLRYAVSPQNPRDKWYFATRALGEGCHLNVDNDANLRVTKVWMN
CVIREGRNVLGILGTGIDLSAFIQEVVNIPQAGITSMFVDRQGQVQAHRDENLVDLASLS
AEMSDKRSVYSLVDAPEDKAVLQRLMDEVAAGGALAKSAFVNIGGKQTLVGVGYLDKLGW
FNVTLMDLDAIIERGLFVPIGLLLLAVMVLVAVLLMLVFKRTVLDRVSALEGVVRSARQG
DYGPAMGMGTGQQDEIGRLAASFTEMAAAVDDNTRLLEARVRERTRELEELAFRDGQTGI
LNRRGFMAAHAEATQSDGYGLLVVDIDRFKSINDRYGHAAGDLVVLEVARRISAAIGNRD
SCARWGGDEFIVLLPGATPEQLRAAATRVMSAMDQQPIALGQAGSITASVSVGACLADAR
DSLDVATDMADTALYMAKAQGRNMVVVFDAELMVPPHSAKA
>A0A0F0C5X9|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MNELEQYKERLRIALSAARICIFEVDILRQQYTFFENAETIFGVSGDDILKDVQPYSVLE
PEAYRLAVSEYFSHPDDWEVIEDAFAQILNGKPAIYDARMKAGGSGFIWCRIHVTPIIED
NKPVRMIGVIMDITDTKKKTESLEQAVNRDAFTGFYNKEYSITLIRDILEERKNLQHALV
ILDIDNFKHFNDTYGHDQGDRIIKSLSRTIKMSFRKTDILGRFGGDEFIIFIPDIEDEKW
LYRKLQNLSRLEIDDFVCTNSMGVAVFPREAANFNLLFKKADIALYHAKISKEKPVFFSE
LDRSEQEIPLR
>V6F084|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MDGGEIMTEGTGRKEKAKAISNQYRSLFENAVEGIYRTTPSGRYLNANQALARIYGYDSP
KALIEGLTDIAHGLYVHPEDRDRFKRLLDHESVVRNFEAQVYRKTGEIIWIAENARLVRD
DDGNAVCYEGTVQDITERKLTEERLRLAATVYENVGEAIIVTDTDDVVHAINPAFSRMTG
FAVDQVVGLKSKFIADEINDPKTVAEAWDFARRGETWHGELWGRRSNGDVFPASVALTGV
QGENGEVGSFVMVASDVTRRKMDEQRIRFHARHDALTKLANRHTVMEALGDAIVRAENEG
NRLALLFLDVNHFKDVNDSFGHAAGDELLKQVARRLKGCVRASDIIGRLGGDEFVVALPS
ITDAQGALACVEKVLYAFSEPFSLPEQELYASTSIGVALYPDHADCAETLLSHADAAMYH
AKAGGNAYRFYDSDMDRQAAERVNLENDLRHALAEGQFRLNYQPKIDGISRKVVAAEALI
RWKHPTRGNVSPALFIPVAERAGLIGAIGDWALAEACRQMRLWLDDGIEFGCISVNLSPA
QFHDASLKQKVERSLSQWGLSPSLLELEITETMMATEVDRAIAIVGELGQMGVRMSIDDF
GTGYSSLAYLKLFPVNVLKIDRAFIKELPGNRKDGAIVSSIATLAANLGFEVIAEGVETQ
AQAGFLLTKGVTLMQGFLFSPAVPPDEFAQLVRTGV
>A0A1Y6L2J4|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MSKAEQHILKNKTSKWHTDHILCSNNMTRRCLVIFFNLLILVIIVGFSLRQEINETRLYV
EANLNQIKNTVDSLAYRNKRYANTATKAIADFDEQNKQLQVLAEIHYYPKLKEFGFNRGI
YPNNLFNGSLIGPGFPNQLIQKDTHLFAVLDELWAEQQVHPIMYNYYYISHALKYFYLSS
KLSVDKFNTTKKFFSTDLYRSQRSVSQPLNELQKGMYYTSPYLDFFSHEMVVTIKSPVYS
NNKIVGDIGVDIPVKSLIQSITLPKTLKSSLNFYLYVIDKKQKIEIYNGYSNRLLPTIPV
HTHLNKNTLLFADISPWFFVNFAIKITILGFSLLIILNYMNAELKRHKFQKQRYQLEAYT
DLLTGLFNRRVMDTIIKGIVTENNKNGQPTAIIIFDANDFKIINDTYGHDIGDLALKHIS
STINDMTRDSDICIRLGGDEFCVVLPNADLEQALIMADRLELAIFSGFFCHYNIKISIST
GCTVIEKKESLHNALVRADKILYKNKKNKDENKKALQQQLNNYIVKSPPTFPKQE
>A0A8F7SJC8|diguanylate cyclase|EC 2.7.7.65|Bacillus sp. LJBS17|TrEMBL
MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYFSTLCVSLTPSPSGFVT
KLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEGLPDVVASFLNQSMKQERL
YNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSLFEFSLFISHDQDQCLGIPAK
ELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQGTYGVLKAEGTGDSFLTDACLD
EMSLLANAAGKAFENAQLYEQSKASIANLELINETSRRLNQRLTLTDTMNDLAVRMAESF
QAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDFYNELKEKLYEGEKGVFIGNGQSVFGK
AGYGSLMAAPMIQNDRLLGFAVLLKQELYAFTFEMYKLFQALIHHATLAVTNSMLRDRLE
HLVKTDQLTELYSRVYLDEKIQYSMKIHQKGVFILVDIDNFKNVNDTYGHQTGDEILIQV
ASVIKSNIRKHDVGARWGGEELAIYLPNVPVAVGKRITERLVYAVRKNTKPEVTISCGIS
CWTTETRKSLKELVHEADEALYSAKRSGKNRLMVHDSIK
>W5SH34|diguanylate cyclase|EC 2.7.7.65|Borrelia crocidurae DOU|TrEMBL
MQSFDNLAKEIKNFSYVIEKDFLIWPKDSLLQPINTELIEKWELKNAIQIERNFFNESLI
RETKKYININEEYDEESIANYHILISNLEEIYETCKKNKKIYYQDVIPIVKKVMEFYKKN
QQTFIKYIKIPKLLSDYHVVHSINTSILTVALGNEMNLNNHKTVELCTTALLHKIGFLFI
PLSISEKKEKLTDKEFEIIKKYPVLGHKIISTTNFSRSICLAILTHKENLDGSGYPNKLK
SEQINIEANIIGAASAYSAILLDKIYKGASSSGASLIELIQDADKKFDKRVLKLIIKVLS
QCPLDFIVELNDNSIAKIIKINEININVPYIKYIIKDGKVIHPNDNQGYIKSIPKTETGI
KKILRQDEINLILKKYGLKEI
>F4TFU1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M718|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0M7JHZ7|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MIAPVHLLLIAVLTGVLSLCVLGSLARSGMAGIRETIRANLLTLLAFFLFGLQATEAPRW
LSILLPNMLVSLALCAYYTGLRRLLGQRLPRHLMGLACATAWLVLVGYTYLDSQVAPRIV
AMSALQMGFMFAVAAAVWQGRPANRSRYSYYFVWSVAMISGVTCALRVALFASGVAHADF
LLQPTAWNILFMTLGVLAMPCLSLGTIMIIHDRMLADREQEASTDFLTGLMSRKAWWLQG
ERYCAHALRTRRPLTLMVLDIDHFKRINDTHGHAAGDAVLRHFGLLATATLRTGDHVGRV
GGEEFSVLFADMRSDAVMEVADRLLDSVRRTPCAHGGSTIAYTFSAGVADWLPGENLQAF
FERADRMLYAAKQGGRNRVTGPGVSLVEPPPLPVAA
>A0A0M7GAH6|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MRINLRGLVLALTIFSAIAATANALYASYRLQREQLITTTLEANRVYAAKLAQSAGGFLK
AAERQLGYSARQIAAHMNAPDMLAAEVRRVQEQSDTFNSVGVVGPDGVILATTQDFRSFL
GTRIDSPGSRAALQSRHPVITKPYVSIAGNLLINLSYPILAADGRFLGYIAGTLHLRKES
ALDDLLGLHHYKDGSYLYVVDGDGRLIYHTDASRVGEVVSGNPVIEAVIEGQAGARRVVN
SRGVDMLAGYAPVPASGWGVVAQRPTAVTLEPIRELLWALLGYAAPLALVFLLAIWWCAR
QISLPLSQLATNVEHHDVAVAMQRVKSVRAWYFEAERLKRAVIWSFTTLQEKIGKLNLAS
ITDPLTGLRNRRGTQDAVDHLQASGTPFSVLALDIDHFKQVNDTYGHTAGDKVIQDVAQL
MRDCSRPGDILCRNGGEEFLILLPGVAPTEAVIVAERLRQRTAEREFPQVGGITMSAGVA
QWPTSGPDVVQVFHAADAALYAAKQQGRNRVVLHGTP
>A0A0M7DRA4|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MHVDLLTLYFITIGTLLASAGLTFWEHRTHPNRSRSLGILAAGFATLAVGCSSVLFRADL
PAGLGSPVSNLIILGGYLLVLNSVASLSGRSYRGRSLALLAVMALVWLGAGRDGQDVVWK
YVSAFPIGLVSALTAWELLRCDSMKMLKTRNFAVAVAGVHALIYFGRAFLLPWWVAAGGP
SVQLLASNITMYEGVLYSVLLPMTLVKLIREETHVQLVLESQTDYLTRLGNRRWFFEQGA
RLIETQSGREPIAVLAFDLDQFKSINDRYGHHTGDLVLKSFAGIARVALGPRAILARIGG
EEFAALLSGDDARRAHELGAAAATRFAEAIANQADGLGIAATVSIGLAYFEDDAPALADG
LARADMALYRAKSLGGNRLEAALAPERVAAD
>W6MEA4|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MKQPIRKIQISIVGVPLFLMGLFLAGMLILQDSGFQKFLAVSLLILIVLFIGLCHSISRP
LYLISRSLHHQDAAPLAGLADERTEFGQLARLIQEFFRQREELIAEIQERQRAEQQLRLF
SRAIEQSANLVMITDCEGIIEYVNPKFTQVTGYTEAEAIGANPRFLKSGRTASEQYRRLW
QTILAGNEWRGEFCNRRKDGTLYWELTAIAPLRDERGTTTHFLAIKEDITNRKKIEAALH
ASELKYRNVFATIGDALFLVDGRDGRILTVNPAACTLYGYSRKELLALKDIDLASDPTSD
AQLPRAESRRLMDRWHRRKDGTAFPADLWVRHFNYKGHTITVAAVRDMSAQKLVERKVVR
LNSLYAALSRTNAAIMRQAKPDDLFRQVCQIVAELEQIVLVSISFVNPETSWLEAAAYAG
TPAALALHPTVPHATTDPSLAEGMGPCGMAFRLGNPVVSNDFLNDPDSGPWQEWANHLGV
RAAAAFPLRRSGGVIGCLTACALELGFFADDITGLLTNLAGEVSFALDLFDRETQREVVA
QHIQHMATHDPLTGLPNRTLLLDRLSQAIHGARRKQHYVGILFLDLDHFKTLNDSLGHDI
GDQLLRAVTERLRDSVRQEDTLARQGGDEFILVLPDMAEPAFAGRVAEHLLRALRAPFAL
YHHIMHVNASIGISVYPVDSEDPMTLIRFADSAMYHAKAAGRADYVFFTSELNVRVSELF
ILSNQLRQALEREEFILHYQPQIDLATYRVTGMEALIRWRHPDKGLISPIKFIPIAEEAG
LISAIGEWTLRTACAQARRWQDAGLPAVPIAVNLSAPQWLQPDLEKQVITALESQSLAPH
LLELELTESLLMRDTDKMIQTMHRLRARGVRFAVDDFGIGYSSLSYLKQFPVDHLKIDQS
FVRDIPADPDDAAIATAIIQLGKSLRLTVIAEGVETSAQLNFLREHGCDIAQGYYFSSPL
PADGCAEFLARQSGVN
>A0A5P9BC22|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MVCMNLGLDIRTLCLIMVFLSGTYFVGLLIKQHSQPQTTGVRTLFYAILLFMIGFSLLSF
GNDINLWVSKILSNATIAGGFCLIVLSLCQLRQSPKHYAVSSGLALLITIAALIYFTFIA
PSTNARVIVMSLYITLCSLASIKVINVGTAKDPSSALRLLLVVLILHSVFMMYRIWFTLN
EGNIGDFLYAGSIHQFAIIITALLISTLGFTYSWILNTRLMQSLYSSSLKDSLTQVYNRG
AMTELIPREIIRNTRFNNSISFIILDIDHFKEINDRYGHQTGDRVLNGIGRLLLNELRGH
DLAFRYGGEEFLIVLPETNFDGACQVAEKLRLLIERQRFWLKQPKPITASFGVSLHQKEN
SLARTVKQADIALYYAKEHGRNAVGCFDQNHNSSPMVDEAYLLGTSSH
>A0A840BJJ6|diguanylate cyclase|EC 2.7.7.65|Niveibacterium umoris|TrEMBL
MKALVADPSRFMRNVFSSVFAARNVDVVQAENGCQALIALESENIDLACVALELGDMQAS
DLLMCNRANQRGNVLPFVAITSNRDKAHVDAALAAGFSECFHKSSQAEFEAYIDAWLSKV
TRKLSGKVLLIEDTESTAQFCTRIMQTIGLAVEVIKSGELAIEALARRQFTLIVTDFMLA
GIKTGLDVIRFVRALEGRPGRTPILALSASDNTARRVEILRAGANDYVQKPVVPEELEVR
LRNLITLAELFDRLETQHQMVKDMAQRDRLTGLFNRHRLEELMPELVAEAHKSGGSFSLV
VIDLDHFKQINDTYGHAGGDQVLVAVAAALRGTSRPQDIAVRYGGEELLLVLPGIALPQA
SLGAERLRRHVESLAPDGIPVTCSIGVAALKPGESFESLFKRADAAVYEAKNLGRNQVIA
HN
>A0A173UCF6|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MSILQKADRCMDEAVALFGENKLFLAEKKAQETTGLYKSCGAYEQMAKTVNFMGVIYASI
GDVSMSIDCYLEAMDVAVEQGSTEIIMLVNNNIGSLYMELGLYEKAVRYFNEALELCKPP
LHGERDNYYQELLMLHLNLCISYTGINEFEKAEKHLSDAILFNEIAGSAKNRFLIDMSQA
HMLWKMGNEDEVRDHVEELVEGAINNINSADYVLEILSLCNLFMNMGEFDAWKKVIVEYE
RFATETENLFFQKTCVKMWMKYESAMGDTEAYNKLCVYYANLHSMQVKEQIKRLGDTIDL
KLQLQETEYERRKAVRLNYTDMLTGMGNKFKMRNDFEKLVSKNQDSDGAGITFGVVDIDF
FKSFNRNSGRVTGDAVLKEVSSIINESIKDKGMGYHFYGDEFYIILQETDEDIIKNIAEH
IRLELAKKQILHESSKVDEYLTVSQAYVTAPDVKVPDEFSRLFKTVDEVLNDVKEKGRNA
YKIV
>A0A8G0RGU4|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain JCM 10418 / VPI 12708)|TrEMBL
MQDSGYFQKMAEGLIHTYYLEQDWNAALSYFDRNQVSWIGVSDQAMALDYDKLKVFFENG
CNSKYEIRLLDENYSMVSKGEDFAVVIAQFLINSRVDKNGFFSLRQRASFIFHLCSGQWK
VTHMHVSAPNSIVREEEYYPEEMSVENYRLLKRLLIEKTQQMEMLAQTTAGGMRGSLDDD
DYTFFYVNDELCNMLGYTYDEFMEMSGGTAKGAIYPPDVAKAMKDCRECFKKGDEYKTEY
RIRKKDGTLLWVMDYGKKVRNANQESIINSILTDISEIKETIGQLEMEKERNEIVSELSD
DIIFDYNMREDELQVFYPASVAGEKDKKIINNARVSEGWKELGVSPEDEAEIYEKIMGIS
NDKISNKTIKAEYQIADGNGKNIWRRVLMRGVFDSEGNLAKVVGKVVDISSEKELMLRSS
TDSLTSAYNRSYLELAVKKAIRNKGVDLYYACLLIDIDFFKEINDKFGHLQGDCVLIEVV
KMCRTLFRSTDIVARLGGDEFMIFMRDIYDQKIVLEKARKMLDIAENYCIREGLPDRLSL
SMGIVIDDDVATNFKQLYHQADIALYQAKQNGRGRYVVFEEGMMHPSD
>A0A8G0RI36|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain JCM 10418 / VPI 12708)|TrEMBL
MGTDKEEVLGKGIFESILEQMNANIFIMDAQTGIIVFMNEMMKRDFGIKEAEGRRCFEVL
QRGMTQRCCFCKRDKLLKMWEAGEEAGITWIEENTLDGRSYKNHDRLIPSQGRLYHVQYS
TDMTELMRLSKNAAMDELTKVLNRRAGKERLDLMLEQSRKEERPLCVVLLDINQLKTIND
NYGHIEGDRLLKYVTCLAKESIGEEDMIFRLSGDEFVIAYYGEDILGTEERMRLIQKEID
KRREEFSIFYPVSFSYGAIQVYPSDTLSVSDILGKADEQMYVQKRQYHIMQAKSRLEGME
CSKGQAADFEYDKEHLYEALIVGTDDYIFVGNMKTGVFRYPPKMVEEFGLPGEVVENAAA
FWGELIHPHDEQYFLESNQEIADGRASYHNIEYRARNIRGEWVWLRCRGKMIPDEYGEPG
LFAGMITNLGKKNQIDHMTGLYNRFKLEGDVKKQLADGDSSMKFGIMILDMDSFHNINDL
YNRSYGDEILRIAGQRISSIIPPNAKAYRLDGDEFGVLVLGGEKQECLSIYGKIQNAYQK
QQEYNGRKYYCTISAGCVFYPQDADNYLDLMKYANYSLEASKDAGKNRMTIFSGSLLAER
ERSLGLMEELRECVERGFAGFAIYYQPQIVVDTQELYGAEALARWKSVKYGNVSPIEFIP
LLEKSGLIIEFGAWIFYHAAMQCKKWMEQRNDFQMSVNLSYLQLLEGDIVDYMQETLESL
ELAPQHITMELTETYLVKADADVLGTMERMRRMGIRIAMDDFGVGYSSLHSLKNIPVDLV
KIDRGFVKGIDGDIFNATLIRSITELCHDVGKTVCLEGVEIGAEYEVVRDMGLELIQGYY
YGRPVPADEFEKQFF
>A0A173U833|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKTIIKYELVINKALRSALNYDTPDEQINEFIRFFGKHIGSDRIYIFEDCDEKHVTNNTY
EWCADGIVPEIHELQNVDMDIIGWWYQAFGSEKNIIITDIEQIKDEHRESYNMLKAQNVK
NLVVCPIRYKDEIKGFFGLDNPPESDTLGLTTFLDMIGTLLISLLKLRNSFTKSNKEAML
SSYSSLSSIYISMALVNVQTHRYHIVKTLDEVVHFLGVKPQSEGEYRIDEDFPGLINSVM
NEFCTKAQRKETLDFVDISTVEDRLRGKNTIVHEFIGKVSGWCRERFIPVDYDADGRLWH
VLYCVENIDEEKRREDRLMYLAQIDLMTGIRNRGSGENKITEYLVRKQCGLLCLLDCDKF
KSINDTYGHAVGDKVIIAIADTLRKSCRDDDVVLRLGGDEFAVFIPGMLDKERAEAFFDR
LFSNIEHIDIAEMNGKHILLSLGACFYDGMDCITFDQLYRRADTAMYDSKKKQGYSATIY
DAKQ
>A0A174AGG0|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKTIIKYELVINEALRSALNYDTPDEQINEFIRFFGKHIGSDRIYIFEDCDEKHVTKNTY
EWCADGIVPEIHELQNVDMDIIGWWYQTFDKDRNVIITDIEQIKDEHKVSYNLLKAQNVK
NLVVCPIRYKDEIKGFFGVDNPPESDTLGLTTFLDMIGTLLISLLKLRNSFTKSNKEAML
SSYSSLSSIYISMALVNVQTHRYHIVKTLDEVVHFMGVKPQSEGEYRIDEDFPGHINSVM
NEFCTKAQRKEALEFVDISTVEDRLRGKNTIVHEFIGKVSGWCRERFIPVDYDADGRLWH
VLYCVENIDEEKRREDRLMYLAQIDLMTGIRNRGSGENKITEYLVRKQCGLLCLLDCDKF
KSINDTYGHAVGDKVIIAIADTLRKSCRDDDVVLRLGGDEFAVFIPGMLDKERAEAFFDR
LFSNIEHIDIAEMNGKHILLSLGACFYDGMDCITFDQLYRRADTAMYDSKKKQGYSATIY
DAKQ
>A0A174FVF4|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MSSNDSTAKEQSFLFNVNKIFLVIHLLMLFMFSSLGVDLMAGVSLIGICFYFLAFSLTKS
EKLSIYVYSVAVEILLHMILAVVCLGIQCNFQLFLIDAMFFLFAMDYVVLRKKKKNHVAI
LLCCVYAIALIILYMLDGFYTPLYKLDSVVIKSISIAMISGVVFLIITCMMCLLHFMSSE
EGAMEKQAQFDALTELPNRFYMMAKLKNLFEAEKQGEYFLAMIDIDDFKKINDSFGHNVG
DDALKMLARTIVNKARGVELSYCRWGGEEFLLLGKCVDGEVPKNFLDELRVEINSKSFWT
SKGSGRMTVTIGAGKYKVGQDYKEWINFVDKQLYVGKCTGKNKVVC
>A0A6N0KGG9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. FDAARGOS_761|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCYLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A378TLF0|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MAGTEVRWWQRPDHYDWYTAYLKDRGLQEQWRAAIVAFTCLLAGVPLILITSPTGPDHRQ
TVAVSLIATGLGALASVVWLRRWPTRRDSMLYCMIASVSTALACLAQSAPYATVMGCTAF
AIIGGFIAHFHAPALVAGNVALALTCAGIGAYRLVSATGDLALAGSGLLIVGALNIGVPF
GIHSLSHALRTDLRRAGHDPLTGLLNRRAFHHAVHELLMAEHTGLDTHLVVALIDLDDFK
RLNDTRGHAVGDQALIAVADAIRANSGARAVVGRLGGEEFVVARTAPDTHPSDWAEGLRR
GIADVPYQVTASIGTAGARLADLITSDLVDILIHTADAAMYDAKRAGGNRVMHRSGPARG
ESNPVRPG
>A0A379N7W1|diguanylate cyclase|EC 2.7.7.65|Roseomonas gilardii subsp. rosea|TrEMBL
MPPIARRVTLIVAGTWLVLVTGLSWWMSQRIMAERLNNLAASAEYDARTTARIVDRLFTE
MTSVANMVAHQSRVIQLAARYRVDPPDLASLTRQQRAAYFTSDPLVRSVGDFMNGLSSDL
HYARIYMNNLSDDTVTASNWAEPGSIVGMIYRNRSYLVDALQHGKGQMFGIARLNKTPSY
FVSSRIEDADDVTQGSVTVKFDAPDMALYLTGQHIALIVNRQGRVTTSSSAPFMLRNVAA
LLPPDILQPPDGDEDIGKPMEVRAMTGPEQADQWQIDGHPYLLRRQSLSNQAYQLLTLVS
LEHLAPMRHQHFWVAGLVAALGLVLILLSGRVAGQMVIRRQEERYAANYDALTGLPNRRA
ILADLDQRFALAKRTGQSILLAFIDLDEFKTINDTYGHEIGDKFLVEAARRLSAGLQPGD
VPGRWGGDEFIVIRVAAPSGPDASDGAADAMRRQLAPLLIGTYAFAGCCFDYPGASFGIA
TVDPSVSSLQAALQEADRLMYADKQARRALRLRVAPRPSMRSEPAGAIAGQASRSAHAGS
ASPPPSGR
>A0A7L6YAC6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C01|TrEMBL
MDKDLSRTTRPTFKRALRRISMISVVVTMTLIWLLLSVASVLTLKQYAQKNLELTAATMT
HSLEAALVFADDAAATETLAALGQQGQFSAADVRDKNENVIASWRYNAQETDDKLSGYIS
QWLFPLPVSQPVWHNGEIIGEVRITARDSLISHFLWLSLAVLTGSILLASGIAILLTRHL
HNGVVVALQNITDVVHDVRTNRNFSRRVSEERIEEFHRFAQDFNSLLDEMEEWQLRLQAR
NAQLLRTALHDPLTGLANRAAFRSTINALMNDDAARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVAKRLAEFGGNRHQPYRLGGDEFAMVLYGVHSEYEVQRICAALAQEFNRPFDL
HNGHLTSMTLSMGYALTWEHASAEKLQELADRNMYLAKHQRVERVIK
>A0A8I1KE31|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWGSISLTYTSINVVEAFTGALLLRKLLPWYNPLQN
LNDWIRVAIGSAVIPPLVGGVLVSLLAPGPEPLRNFFVWVLSEAIGALAVVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAQNPVALTTQHVGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMV
TVYEPQQERDHNTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFNEFFRASAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A7U6IWH7|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILATWMLFSWGSISLTYTSINVVEAFTGALLLRKLLPWYNPLQN
LNDWIRVAIGSAVIPPLVGGVLVSLLAPGPEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVVSLMIAQNPVALTTQHVGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSVMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMV
TVYEPQQERDHNTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A0J0FV94|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MEKRKKPTLERATWPTRHAMVMHGLAMNLPWLAFVNISFAVMILLRHVLLNTSDPLYPHS
PQLTRMVDASMLGIIILSAALILMAWRRIAGISVVLFICSAIWSVSCFWFITQLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPVASWIRNDGLNLHFFVIWSVFTLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKTFSV
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPEN
IVEKVALRIQDGLRTEAIPHSASTVSDRVTVSMGIASMAEGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A0T9UJR6|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRVFGLGIGMLCVSAVLYTQNSPLWLWIMLALNGLGWP
HIAFLLASRSEEPFEQEILNMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFSPETSPLQVYACLPMIIIYPSLLGLVTYHTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQERLADLVF
EQAPPLQLRVSAGIAEYKQDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A376FMQ5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIGSVIVIQDVTESRKM
LRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFIDLDRFKAVNDTAGHA
AGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYIAGRLIHTINDYHFM
WEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMVTVYEPQQGAGSQHA
QHDVA
>A0A376FAJ3|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKIFSVIMLDIDYFKRYNDTYGHQAGD
DCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPENIAEKVALRIQDGLRAESIPHS
ASTVSDHVTASMGIASMAEGLAGTEIIARADAALYRAKEAGRDRVCR
>A0A380PWC9|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MLIMALYRFRNVVLLRSILTTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLI
DNTLEANRVYATKLASSTEIFLKSAQRQLHYSSVIAARHFDDQAILQAETARLKYQTDSF
NSVVVTDAHGIVRATSPDSLQLLGHTLTSPGSVEALKLRRPIISRPYMSATNNLVINIST
PIITPDGHYHGYIGGTIYLRKQSILNELLGEHYYRDGSYIIVLNNERRILYHRNTNRVGE
ILESSPLTEMAKTATNGSLMVTNTDGESMLAGYAIVEPSGWQIITLRPEAATLKPLEGLM
LKGLGHITPLALLTLIGVWLLSRLIARPLWLLAGSANDMDKPDIASSIKEIPSWYFESTQ
LQRALLIGISLLQKKIGKLKFEAQTDPMTGLYNRRGLATTLEPISQLEQHFSVIALDIDH
FKAINDTYGHDVGDEVIKQLAVQIRESSRDTDILCRSGGEEFLMLLPGTTPDVAIQVAHR
LRHNVEMMVIPNIRPITISLGVAYWSGDGIPEDALKRADEALYRAKDQGRNRVEIG
>A0A8J7VD84|diguanylate cyclase|EC 2.7.7.65|Candidatus Didemnitutus sp|TrEMBL
MPTTQPTRILLIDDDRLQHHLMQGFVGRFRGGPWTLDTASDYTTGLKKLLSGKYQVCVLD
YRLGDRDGLELLREARAADSTTPVVFLTAEASEEIDEAAMDAGAMDYLVKSELTPRIIEH
SIRYARKLGNTLEQLKRLATRDGLTGQLNRREFERILHEEWQRSVRFNHSFALVLADIDH
FKRINDTHGHQVGDEVLKHVASLLGGQLRTVDRLARYGGEEFAIVMVETDRKQAVEAMER
LFALLAETPCQVSPTLSLSVTLSAGVAEMPHDAASPSELVAAADEALYAAKKAGRNRVFT
AKRARKE
>A0A806X658|diguanylate cyclase|EC 2.7.7.65|[Enterobacter] lignolyticus|TrEMBL
MSHVVKVDSLQWLNTLSWRNNPVRVVSLCFFVVLVFSTLLAWREVVVLEEAYISSQRNSL
ENVANKMDAQLQANLDGLKFYRNGMQAALQTPLAFSGLRGAAEAFMQRRQQPQWSVALDN
RRTLPVYGVSDDFIAQSALLSRDNPRLSNELTATLEVGYLLRLSTSVRRVAQRVLYVSRA
GFFLTNPPITDPKDTIEQYYALVTSPWFTSQTQRNNPGRGFRWQPHAPDSNVQSVAVSLP
VDYDHYWYGVLAMEFSLSQIKRYLVVASEGEEEGEYRLYDRRMNQITSLLTDGVIATSLT
DPDKAQIAHAFEHDTRGGLRLDTRYISWQKLQNFDGVLIRVHHLQEGLRGEYGSISMALG
VLWILFTSMLILAWVVIHRMVNNMTALQKSLQWQAWYDGLTRLFNRGTLFERANTAMKSC
REQQKPIAVIQMDLDCFKSINDRFGHQAGDRVLAHTAGLISSRIGSADLAGRVGGEEFCI
VLPGATKEAACLTAERIRERINSRELLLGKGVMLRISASFGVSGSDESGQYDVEFLQSVA
DKRLYQAKQDGRNRVCCSEPPPAE
>A0A0M7AZV2|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MDTVRPENEEERIETLHELQILGSERLPEFDSVVEALAAIFDCPIALVSLVSEDEQWFKA
RCGLDVEGTPRDISFCQHAILSDELFIVEDTHADKRFKNNPLVTGAPNIRFYAGCPLSID
GRNRLGTLCVIDRVPRSPSRQQLNQLRRLGKVVEGLIKSHEIRREKDAALAQAEQEHELA
VQKNDLLEEITSVSGVGGWELCVRTKTLTWTDKTKEIHEVPSDFRPTVDFALSFYPPDSR
HIISKAVEDAIELGVSWDAELPFVTAKGRNIWVRAAGRPIVKDGEVIRIVGALQDVTARK
KTEQSVRCSESMHRATLHTLSEGVLLLSRSGRIRSINKAGEDLLGCSHEDVVDTRFKDLD
LEFRFEDKAFNSPDDLFRQIANGSDHVNGTVVHVTRRNETGGAWLRINAASIGETNEFGL
DGIVVSLTDITETKTQRDTLQAIFDNFPGGMVYFDEALHLQNYNDAFQNAFKLPKELLSQ
KPHLKDTMMYAARQEQRVASKAEKVVEERYNPFMSGKPVQLERVTADGTVLDVRSTPLPN
GGIVFSLLDISDHKRREQTIRQSEVVQRATLEALSEGILLLSRDGVIESANPVAEKLFGF
DDNGLTGLRIDELARSVTLESSEFINNSDPLKLAVHDPDAVTDLVASLSTSYRHGLTWLR
INARPIDPLGENGLDGVVVSIADITETKEQADTLQAIFDNFPGGFAYYDENFQLGAANSE
FGHLLGYPQDFVDQKLHLLDYLKYNAERGDYGEGDPEQLALDKFHSYDRTQPHSYVRGAA
SGSYLEIRGTPLPSGGFVYNFFDVTDRKRMESQLAESERASRSRSLELEAILANMRQGVS
VFDKDGRLRLWNKQYIDIFNKPEDDVREGVTLVDLIEAEKARGEFDGDVIEHVRDLLIRL
SAGEVVRSKFRHPSGRFISAVHAPLPGGGWIGTHEDVTKSELAVQKIEYAAHHDTLTGLA
NRTLFNSRLDETLEELDQDSESALMLLDLDKFKPVNDTYGHDAGDALLKQVSERLKACVR
STDLVARLGGDEFGIILNRASRTVAEVIASRIVHKLQGAFSIKEHTIRIGVSVGISPISG
SRSDANAIIKNADVALYDVKNSGRNDFRFFDLPAEPGAMNA
>A0A822WUL2|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGLIVNLCFITVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQNSVDRMLLFRQGMRDAIETPLAFDVLQDAVSRFNAVRMLPTWQLAVDK
KRTLPINGVSDAFVDKTTLLNRDADRISHEISAALEVGYLLRLASSRAQTETRVLYVSRA
GFYLSTDTPDREDDITARYYHLVTQSWFTQQSERNNRARAVRWFISTASFWTGDKRTITA
SVPIYFDHYWYGVVAMDFTLDTMQRLLTDATEERTEGEYQLYDTRLNMIATSAHAGSPVN
QFDERETAQIAHAIEHDTGGGIRLGSRFITWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKLLA
KKCHQQSLPFSVIQLDLDHFKSVNDRFGHQAGDKVLSHSAGLISSALRKNDVAGRVGGEE
FCIVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSARENENYDFEQLQ
SVADARLYKAKQDGRNRVVWHDHDKK
>A0A3V9Q1T0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARATLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379UPQ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MHRWTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDIIQENVMSFLTPVYLAGTLKGIVM
VDVNQDNLKNIFYTQDRPLVWRYLNVTLKDMDSGKEIIINQSKNNLFQYVNYSHDIPGGL
RVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKI
LTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIKTSIRKSD
YAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDA
YQASDAQLYLNKQQKQHRSS
>A0A315G0B3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERAVLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6Y4XZR0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLSGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A653LG89|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. G8|TrEMBL
MSARILVVDDVDVNVRLLEAKLTIEYYDVLSCNDGASALAIAAEHQPDLILLDVMMPGMD
GFETCRRLKAQAETRHIPVVLVTALDGRQDRIRGLEAGADDFLTKPIDDVILFARVKSLT
RLKHVMDELREREESGRRLGVDSDGAARLRSEGGRVLIVDDDMRQAEKMAAELSGEHRVT
IESDPEAALVAAKGALDLIIVNVAAAGFDGLRIVAQAKSGDARRAPILAVVEPVERPRMV
KALELGAADILPRPIDTEELSARVRTQIRRKRYTDFLRQKLDSSMEMAVTDALTGLHNRR
YMTGQLQALVGRAAQGGSQVAALVLDIDHFKSVNDSFGHDAGDEVLVEFAVRLATNVRAV
DLPCRMGGEEFVVVMPGASLEDAGRVAERIRRDVASAPFRVMGGKEQITITISIGVAATT
GDGDTPEGLLKRADEGVYEAKAAGRNKVIAKAA
>A0A2S3U862|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum subsp. plantarum|TrEMBL
MTWSNWRISPFVTSIFFILGVLTLYWVLFNWITTWFHARHINIDDDTVNAWHGVIYMLVF
VFVMQLSVVGKADSWEFVNFHLIAVVFCSFFLNIRMPYYSLLPVVIVYMVFDQSIFYWES
WSYAVVFVLFFWSMNYLRLWVPKHRYPWLYYYGAVAFYGGILWGLIKLKYSLDWDNTLQE
YGYLMIFAGLLYAYVNMLTQDSEIKLRLAQFASHDALTETENFAAYTEHIKYLFDDSAKN
NLNLSMMMFDIDHFKHVNDTYGQPCRGPRFARSCRHGHDGLGRQ
>A0A8G7YQG7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNTIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2A3WX77|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A478KWD2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAKVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A779QBG9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGITFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A811VT40|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSSYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQMIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKK
>A0A8H9Y1Z1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NVLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGKLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H1VSV7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHTWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7D5L7S7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFIS
HWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHAT
GDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDL
HNGHQTTGNAANLLI
>A0A6G4C4B0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIFYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLISDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A826KVL3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAYNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8H0MYZ2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVAIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A152JW06|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A2X6QTJ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNVIDKNLDGEYQLYDSKLRLLTSSNPDHQTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8B4NE59|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFLEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRTKKDGRNRTSTMRYGEEVV
>A0A6M9WWC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGSIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7B6DC64|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHHQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWHDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKADNDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIHRV
>A0A787GED7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLSALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A4C4K7G9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWLAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376TFL3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNETYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6N4P1T6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNMPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3W5Y370|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDCFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A0F3U7K8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKLTGRNRCMFIDEQNVINRV
>A0A4T8I1D7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A4Y8GWR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDTLVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A509E880|diguanylate cyclase|EC 2.7.7.65|Methylobacterium symbioticum|TrEMBL
MHATANSATFLLVINFSIGLSFAVAFLALTWRSSVQLGGWCAAGFFAAATTVSVEAMAST
IPSVRLTSTASFGSLMLAMTAITAGLVRHYRPQASISWLAAILIAAVLLNALVIFDLRRG
SWEWALGYQGPFSLMLAIGAGFVLRTSPRRPVDLALAAVLGLSAIQFTLKGVLAGIAGGG
PGVRDYVVSSYAFYSQTAGGILSLLLGLSLIGLVVVEVMAETRLRLQQDALSGILNRAAF
LERVPAVLRLSAQRPSAIILADLDHFKSINDRFGHAGGDEVIRSFGANLRAYFGDDALHG
RFGGEEFCILVPDCGPAAARVHLEALQWLGRQNRYALLPTDTVVTTSFGVAFTTHDEPFD
RALHRADMALYAAKAAGRDGYRFAPIASSTDAELSCVRVGNYPPTATRLMS
>A0A378BIF8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPREQELLSRAFVH
DNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLS
WLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAIAVASDCQRSGRPLAVIQLD
LDHFKHINDRYGHQAGGQGAVDGGQYAVQRGSAGRSAGQSGRRRVLYRDAEYHPAGSGGG
GGAIAPAYSGTGSLFA
>A0A376LLL6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFLPIASTLVSHPPPGWWWLVLVGWAFVLPHLAWQIASRAVDPLSREIYNLKTDAVLAGM
WVGVMGVNVLPSTAMLMIVCLNLMGAGGPVCLSRVWC
>A0A1C3RKC2|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MLDNTKQNDTHACELVGGICKLASCLEGRASASEREEALHEALRLAYKLEGTLNQQNDQI
TYLDRLAMTDCLTGLLNRRGFQAELHRVLASARRFKETGILAYIDLDDFKEINDTYGHAC
GDEVLAHVSRIMERMTRETDYIARLGGDEFAILLVRTSWGDGQKCIEKITTELNSISFRW
QEHVINLKASMGIQFYDSLSKPKGLMNAADEAMYATKKIRNVKKPDKCTLNAAE
>A0A447XTG1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTWC
>A0A7H9LVY8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSKGNQLSRENKSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHDHNNVTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSSEE
LFDPRELASLAQAMEHDTRGGIRMNSRYISWERLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQNSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQVHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDSP
>A0A0D1MTT3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MPSVSPEVQAKEWHSMVSQYPCTLTQSLQGLVERNKVMLAARFYEHMLADPNASLILSHD
EVKSRLGSSMQAWLVRVYSVSPTDDCMPLVALQKQVGEVHARIDVPLHLVLSGARHLKKL
LFQLILEQQWASEAQALRLASETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNIST
ERERQRGALLDWENSLMFDLAMGSNGVNLPRLAASDFGLWFRHKGAYAFQNTSESDQILK
IIRHMDDVLLPMFLASMHEQETRMRLLRDIRDQTKSLMFNLDNLFNTANELESGRDVLTR
MLNRKFLPVVIGNEIAIAQKTGQTFSVFSVDIDNFKSINDNFGHEAGDAILQQIAEILSS
HSRAGDYVFRMGGEEFLMILVDIDSANAMKVAQKLRRKVEAEKLQLTEGRRHQVTVSIGM
ATYNGHPDYQHLLRQADQAMYQAKQGGRNRVVAYGELTSPE
>A0A5E4T5F3|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MTTHRPSSPPMPPGASSVAGLLPADASAEGEREPPLATSHVAAPDPMRGRRPSLQGMLRR
THLRLAVSAVVLAAVSLSLVAWIALRAYAENNLLLIGRSLAYTTEAAVVFGDRVAAQEAI
ALIASDEDLVQVRVFDANNAPFAQWRRPDGGALTQVERVIANFALPGPVTMPIRHDGKVV
GTIDVQGQGHQFFLFLLSGVGGVLACLLVTFAVANVLAKRMHRDIVKPLRALAEVAHAVR
RERAFHQRAAATPLAELKELGDDFNALLDEFEGWQNHLRAQNATLAHQANHDRLTGLPNR
AYFESRLVQALADAREMGTHVALLYLDSDRFKEINDQLGHGVGDVVLMTIAERLRQPLRE
GDLVARLGGDEFAVMLVGVRQTSNAVRLAQSLLVAMEKPIVLPDGGEIVTSMSIGVALYP
THAEDAAALLRTADAAMYQAKRAGVGTWFVAGSPKG
>A0A385ESP5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii WM99c|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIGSFAGAFTGYMIADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGALFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKNHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLGNTISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A1S7TCI6|diguanylate cyclase|EC 2.7.7.65|Agrobacterium fabacearum CFBP 5771|TrEMBL
MIETIDTNIFNLAPVAMWIEDFSEVKSQFDIWRAQGVEDIRAFLLEDLSRVAACSQKIRV
VQVNAKTLELFEARDKAHLIDNLHRIFRDDMLESHVNELSELWAGKTEFISNAVNYSIGG
KRLDIQLRGAVIPGYEQTLGRLLLTTEDVTEREEARRKELFNRRYAEGMFQHSPVSLWVE
DFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVIDVNRATLDLFCAPDRQVLL
QRLGDIFRGEMEKPFREQLMELWNGNLNHHREVVNYALDGSERHVLLHFSVFPGHERDWS
LVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEMNRLERSTIRPVSAIVIDLN
GLKDANDKLGHDAGDALLRRLGEVLNGVVTAPNHAARIGGDEFAILLPGADKQIAAAMVD
TIYELLKINNQFYSNAPLSLSLGVATSEAGETMESLVRRADMHMYEQKNAYYAAMRNRSA
DNSDTTKASPQPEASSLKRLL
>A0A6I6WKP3|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MSASPPMFLTVDVRRSGLRFSQRVYIPRIVGTILCSLFISSVLMTKSVPTLLWVLLFLNT
FIWPHIAYMLSLRSRDPMRCEKRNLLLDVVFGGIWIGFMGVNLLPSALIVAMVGMNCTAG
GGIKLFVQGIVLLCVSCALTLVLFAVPVSLDTTPIQIYACLPMLLIYPISLGYVTYATAL
KLAEHKRMLMEVSIHDGMSSLYNRHHWERLLKHEYDICQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMVQYMDWLKAADMALYRAKNKGRRRTEVA
>A0A714N6P3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. CT18|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLCDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A5B8RHH6|diguanylate cyclase|EC 2.7.7.65|uncultured organism|TrEMBL
MVLFDIDWFKSVNDRFGHPVGDRTLIELTHRVAAILREADQFGRWGGEEFLVLAAHTDLR
GATVLAERIRRAVADTPFPGVGPVSVSLGVAEMRFGWTLAMLTERADAALYEAKAMGRDR
VVVAPA
>A0A377HK72|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MYTLRQLVSLALTSVLFLLSPFTCAETQRLIVTGSSTWQPFSFINGLGEPDGIMVDFWRL
YGNVNNVAITFELKPWSDSLDYVRTTPGVVHGALGYTSDRAKTLTFSRELPLKDYKVNLF
VQKDLPFDALHALDSTVIGTVKDSTKHAFLQSRIPEQNIRLFPTFSSLNDAAYRGEIDVF
IDDLNTALYEMRHSGNRGLFTPRQTLYSFPLHFAVSKDALAMVADIERGLDNITQEDVEA
IYNKWLPQNKQHSTQSWLDKTLQYLIFTALLIIATVGLLFYHCLLKNRTVALKNAIKALK
DSKRQLECATQNDPLTGAKTRHQFFAALSEKRFSLSPYVVAVLDIDRLKQINENYGQDVG
DMALKHLATQLRLQLPRDTLYARLSGGKFAILFELSDSSQAQRKLQQLQKMLQLSLLYID
QQKVPLTFSAGTASYPYDGENGEGLVQIATTRMRANKPTASNLNTNSGEGKTLTEHHWA
>A0A839F7F8|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium sp. P30BS-XVII|TrEMBL
MYTEYFPIVADLVHRLGLVALVSMAYGSIIRGFHTPMKRSFMVGLLFGCSAVISMLDPVI
VDHGIIVDARSILLALSAPFGGVVAVLVSTTLTIISRILIGGNGVYAGVVGIVIIGLISL
IFTQVYRPKTYSWKHFIILGLTVPLYTLSIFVLPFEQALPIFQRIALPMLTLSVTGIILI
SLFLHRERLRVDRVKTLEVDAYTDPLTNLANRRLFDRVARRTFRKAASTGGDVFSLVMID
IDSFKSINDHWGHSNGDLVLVEISTIIRSLVRKSDLVARYGGEEIAILMPTADAEEAMAM
AEAIRRRVNETFFDFGRTQAHVTVSAGVSTFTSRHQSLTELIEEADIALYRAKRLGRNRI
ELASIAA
>L4J9U6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE146|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRQLYLAKQAGRNRVFASDNA
>A0A8G0T6D1|diguanylate cyclase|EC 2.7.7.65|Roseovarius sp. SCSIO 43702|TrEMBL
MPGKILIADPVATNRIILKVKLSAGHFDVSQAGTAADTMRLARDISPDLILISNALPDRD
AAGLIDALRARPDLPDIPIAVLLDGGADAAADADLRARLLARADAVITRPFHDALLLARL
RGLLFRRNSLRDLRQQATTGTAGFAEEPAALDRPGHIALVAPEGAPGSILMRGLEGRLSH
RLRLVDATRPFPALSRAPRPDALLLHLADLPHGDALRLLAELRAAPDTRQAAVLALLDTE
DEETAAQLLDAGLDDVMLGPVAPDHIALRLDRLVRQAQTAHVLRTRLRDGLRASITDPLT
GLYNRRFALPFLQRLCEGRTDDRGGPPFAVMLADLDHFKRINDRYGHAAGDEVLAQVSDL
LLGSLRHEDVVARIGGEEFLVICPGLEASAARMAADRLCRRVAEIPMRVTGEPQSVPVTI
SVGVVMGGARTGAAGGAEALLAQADRALYASKAQGRNTVTFQSTRPAA
>A0A3S4PTT4|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MTKNAPQHTEAGPDSNHSQAIDTILNSLDALVYVSDLATYDLLYLNDYGVSAWDEAKGKK
CYQVLQSGQSSPCQFCTNPKLLDDKGNPAGVHVWEFQNTQNKRWYQCRDQAIRWTDGRLV
RIEIATDITERKQMEQALIEAKSTAERLADTDELTQLYNRRAFFNLGRQIAQQAQQPLAF
IMFDIDHFKRINDHWGHAMGDAALIHIAKLTQTKLRSHDILARLGGEEFGLILPNTHHEQ
AWQVAESIRHGFDTQPLQLDGHSIHCTASFGIASLSLPQVNHPDEAQTLLETLFNNADQA
MMQAKRAGRNQVCDAA
>A0A1C5V7D5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKKIMKDNSEYRTKRQWFFIVLICLLVMVFLTTFLMKRYRQKTERVFSELMEETLLSAHS
EALSEIEAFCDDQGETADLEKAWKMIKQDKNRVFHYLCDSKGVILAGDMKIFDIEYTVDT
ELRSIRIKDKDIEKVEDILANLTFGQPYLFSELEKSDIYLAASKLEDRDCILVSGYRSNK
IKNYRTMLINGNRALIITLFGCMSIIIILIGRLYMKQQKRAMKGQARYDILSEFSDTVLF
EYDCLDKTLVFTPNITTLFGLKEIGQIRPFENDTDFAMVHPDDVEKVKNLLSTIGDKKDE
IDDFVIRFKDKNGNYRWVRWMGRLVRGRLGTPQVFLGKISDVQDEMTKEQDLLEKASIDG
LTGALNRKSAEAKIGELMQNKNCKGYLFMIDIDDFKTVNDTMGHAMGDLALINLVKILKE
NFRKDDIVGRLGGDEFIVFMTDTEFAADAEAKGAEILDVLAASKEEPHFTISVGAAAYPA
AGQDYENLYLSADHAMYVSKKTGKNRIHVDNGTVEKNDEK
>A0A3D6AEQ8|diguanylate cyclase|EC 2.7.7.65|Oxalobacteraceae bacterium|TrEMBL
MPKITPEQLAAEWRALLRRFQEPVPQRVRALVERHRDALASHFYEQLLQDPVASRIISHE
QVKARLHDSMMRWLDSIFTVDPDADLQALIAQQIHIGEVHARVEVPVYLVLRGARHLKKK
FHDLLEADPTLEGRQQFEAARLVSGLLDVAMEILSFAYAGSHDRNSRAAEAYRLFSVVQN
VSTERERQRAALLDWENQLMFALAVGLEADQLPSIGTAEFGLWFRHKGAHAFLGAAETEF
ILQAMDRIDQALLPAFNRSQENNAQQRVQQLRELREQTKAIGFHLDTLFQQNSELEAGRD
ALTRLLNRKFLPVVFTKEVDYARERDASFAVLAIDVDHFKQVNDNYGHEAGDMVLQQVAV
LISNNSRGGDYIFRLGGEEFLVLLVDVDSARALKAAEKLRRQIAEECFHLPLDRTLAVTI
SIGVAVYDSQPDYRQMLRRADAALYRAKNEGRNRVVLADD
>A0A1J5NT54|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MHRFIRLYWVPIAALIILFSARFLTPFLYRVYSHDQYLSLHTILEFATIFFAFSIFSMIW
LMHDAIKEDVSIFLLVVGIFLLAAGVIDLFHTLSYYGMPAFFTPSSTQKATFLWLWGRLV
VGTAFLLAFYSWHLRDHRQTLIRMLLAFSAVLALLSLLISTIWLDRVPLLVAEGKGVTPF
KKYMEYLTIAIMILNTFLLLKNRRYFSRSVLVNIGNFFGMTIISEAAFTFYISIYDTYNL
LGHIYKVMAYYFLYRAFYLAGIVRYFSNMNEIAALAEEVIEHSDTLKEVLKIYVEKLARI
IPRAGQIAIFLPASQENCYYLALCQGQFCQLILEHKNICPQNFMDIMGRELKILKWPVKT
LKGSGLLEVIKGQEDFWDRVVEMLYLPLHRQDMDSGFMWLLNFNKNEGFTLEDIDTVRTV
AKLISLSVIQARHNEIINRLSYEDQLTGLGNRRYFIQELKKAIYDSKRYGHDFTLVFVDM
NNLKYINDTYGHNDGDTALQTLAAALRRNLRQGDICARLGGDEFGIVLKYVGLNEASSKG
EALRQELANVELPGYKWSFSAAVGWATFPQEAKDIDGLMHLADKRMYMHKNKKRAEMSC
>A0A0D8HJ15|diguanylate cyclase|EC 2.7.7.65|Acidithrix ferrooxidans|TrEMBL
MINKPLVVSQKREFNMIDSRSWHKGRFSIVISIVALTLFCLDIVLSGGNLFANAFSVHMV
RTTTLFGLYLATESFSVLRRSDNKQRPSEVYSWTFLFALILVNPSPLFVMGIAIAKVFIE
LIARRSVGTAIFSGASLMISLSFGELILLVFRVIPEAVPSLALDRVDLFTVVFAGLFIAV
FHGVLRSIYWSNSRDSSWILGLRSETFDTTVYDLVLIMLGVLVTTFVLSGLESLPLAGVI
GFAISIGASLSIEAKRSRGLDSLTNLPNRWAFERQIERYVLEASRRHGRFGVLLIDLDDF
GELNDKLGSAAGDATLRAMAGRLMAPRDRAI
>A0A1J5NMZ6|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MNILQLMPEFDRESFRALLVPLQQGKKEKIVFDTIHRRKDGSLYPVEAHLQLSGHGKDGI
GVAFILDLTERRKMEEKLRQQGEFLRSLLAALPVGIFIIDPASHRIEEANLEAAAMIGAA
PEEIAGRSCWEFFPQSAGRCPFAASNEEVERSERLLRRKDGREILVLKTVKRLRTDSGEK
LVETFVDLSERKHLEEELYRLSITDPLTGAYNRRYFLEMLAREIERARRTGLPLALIMFD
LDHFKDINDRFGHAAGDLVLKSLVAAFKERLRKTDCLARWGGEEFVILLPDTAAEGAASL
AEELRRRLGQMEIPGVGQVTASFGVTGYCPEDTVDTITQRVDKMLYRAKKNGRNCVCACQ
>A0A0D8HGR2|diguanylate cyclase|EC 2.7.7.65|Acidithrix ferrooxidans|TrEMBL
MQVTTSSDRELLGSLRSFLTNTEKALILVAREEIIWINNATATRMATAAIDIIGQRLDEI
TTIEIPTKLNHAQNLEGELVHATGITIPISCLATPLSNSEMMLEITDRTEFDAHHELALY
QERLWVLANQIPIGIFYSEVGLRTEFANDFLAQIYQSPVETLLGTGWIDQIPPISRPIIE
EAVLKTLSGVVTESEIDLVTFSGTTKRILYTISPIISGDGRAGFAGTAEDITDRCLREEQ
MAHAATHDPLTGLPNRAAMMNDLYSHHQALTNKEIKGITVIFCDLNDFKVVNDSLGHKAG
DRILIEAANGLRYGCRDGNLAYRYAGDEFVVLCPGIFDEVEATTIIAELKSSMEAPVHFA
NTQIRISGSFGSFTSSDPAISPEELLNRADASMYGVKQHSKQRHEG
>A0A8F5J513|diguanylate cyclase|EC 2.7.7.65|Crassaminicella sp. 143-21|TrEMBL
MKKLMGIGNMSFSKKIKISLIFSFMPIILLGILYFIHSRYIVVESMKSESLKIIKNVQKI
YIEKYINDVEKDLNLLYKEIHYSDLYDKEKMRKYMKEWREYLKYNTNVDYIYVGTKGKEI
YIFPCWENNDAHYDPTKRPWYIESLKSDKIQWVSYIDYKSKKRLISAVKSIKDSKGHVIG
VLGMDTTLDNLSESVSKVDLGEDAYVMIVNKEGNIIAHKDKKQLWKTVENNQWYKVVKKE
KQGVFYDKKKKCFVSFSRIDKNGWKIIGVIPDKHLEELLKPVGLYAGIIILVASLLFFIV
GNLIIRKLKRENKNICTIIEAIENKDLDIFEIDYYRKDEYGEIYKKLNNAIKMINRIKND
AIYDKLTGVYNRRYFDQALEEMIHKSENFTLMMVDVDDFKKINDTYGHQKGDFVLREIAR
TILKSIRGKDILARYGGEEFIIIFPELEAKDVYSITNRIREKIENINWKEKEMKITISAG
VSTYNGQTKEDLINEADELLYKAKSLGKNKVIFKELL
>A0A174PDG8|diguanylate cyclase|EC 2.7.7.65|Clostridium baratii|TrEMBL
MNILKDISERLFPFKNLYDVIRLVDPINNKVIDSYPDNLIGYNKSLTCYKFWSKDEPCEN
CTSLNAYIENNTFYKVEVKDDELYMIISSPFEINDTTYVVELIKNITKTGYFKDNDYDDS
LKNMFNRISNLLHKDDLTGVYTKKFMYNSLTKELATTYKSYSFLSVMMIDIDFFKRINDT
YGHLLGDEVLKDFVKIISSCIKGENALFGRFGGEEFIIILKHNDVDKITSLGNTILTSVE
NHLFKYNDISFKLTCSLGVYTVPAKDCETSSMEDIIHISDSNLYSAKKLGRNRMITSNK
>A0A7X0PHW0|diguanylate cyclase|EC 2.7.7.65|Acidovorax soli|TrEMBL
MTDTRMFDDTMRPQAPGDFDAMVLLVDDQAMIGEAVRRMLASEAGVDFHYCSDPAEAVAM
ALRIRPTVILQDLVMPGIDGLELVREYRQTEALRDLPIIVLSSKEDPKVKSQAFAAGAND
YLVKLPDTIELIARIRYHSRAYQALRQRDEAYRALRLSQQQLLESNLALQQAMKMDGLTG
LSNRRHFDEYLDIEWKRARREQQDLSLLMIDVDYFKLYNDNFGHVMGDDALRSVAQVIAQ
SFSRPGDLAARYGGEEFAVILPNTSADGARSLADEARRAVEKMAIAHVAPVADAPLTVSI
GVATVVPDRDMQPVALIQRADAALYEAKENGRNCVGTV
>A0A5S9PX40|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium vanbaalenii|TrEMBL
MTGFTGNLENVPVGDGVVMRLLLQWWRQRDEYQWRIEFLRSRGLLPILRYLIAAIGTTMG
ALAALNAVAPPAADGTLIRVGWAVVAVGSLAWGVRWAVLPWPSPRESAVLVVFVDVLMTL
SALLFGDPNLAMSGIPILLCAGGYVVFFHGPRLHVAHIAWCTAAVVGIAVWLAMSTPEYG
LQVAVSRAVIALLVTVCILPALQFGFWLLQGSSKQSLTDPLTELTNRRGLPVSMQRLNEA
SPDADLCALLIDVDGFKGVNDTLGHAAGDEVLIRTARRIRASVRSDAVVVRWGGEEFLVV
DRIRADQAGAVAERIRSAVAAPAQPAVTVSIGLATSTRSGSDIGEVITAADAAMYEAKAR
GGDRVAIAAEIC
>A0A8F9V0R2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MLPAQDTRGKGLSLARRLYRSRTLGLALGFFCVAAGMAPLQPAPWVWGFMLFNAFAWPHL
AYQWARLARVPFRAEYRNLLVDSLLGGFWVGAMHFNPLPLATTLGMMAMNNMALGGLRFF
LAGSAAQVLGMGVALWLFGPAFVAQTTPEQVYACLPMLTLYPLALGYICYQQAVTLGRHK
RELLALSRTDSLTGLLNHGAWKDQLEIEFQRCKRQAHGGAIALIDIDHFKAINDTYGHVA
GDVVLRQLSKLLRQNLRVSDQAGRYGGDEFCVILPDVPLAHAAELMEALRGRFGALGYEQ
SPALQVSLSIGLAAFNPLHDDAMGWLNDADQALYAAKTCGRNNVTCHPPEQPSRRLLNSL
>A0A8F9XZ94|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MSDDANRWKEKYLKSIEQQEKLERRWAARLDLLRRGLVRSTLAAEGTDRAVDQCMKEMRE
VVRTDDMDAGLAALLPRLEKAVLDSEQRRETRVEQMSSALTALVSQLQSLPLPREVSRPL
KAFAKQLDGRVGQAREIPLLLGELSSLQGKALSQLETPAEPDRPSLLQRLFGSREASETP
APAEEAVATNPPLPAAAAEAHPQAEEAPAPEDGAREHYQTPTQALPEAVSAPAAPAPAQP
EVQLEPEPGAQPVASDEPEVAAVPAPAPVVAFVPPVLVQEAPAEPVPAIEVEPQATISPV
AEPQAPVDPGVVAASDSPPAPVAEAALNPDELVPLPTVSPAVLLDSLPLPAVMAEALAAI
DPEQSEHDVLYALPDSPEPSYSSVAKHIEHTLLGLLDDLSLPERHRPQAEAMRDRLQHGL
NWYELLPILDDLAVLMLAITDSGQHEFETYLKQLNERLEAFQSNLQAASDGHADSSSAAR
AMDSQIREQVDGLQSSVQEAADLDDLKQVLESHLEGLLGTMDHHQKQRDEREREVAARLQ
SLAERVSSMEQEAQGYREHLEEQRQKALIDPLTGLPNRAAWSERLEHEVGQWQQHGNSLL
LAMLDLDHFKRINDNYGHLAGDKVLKIIANVLRKRLRGSDFIARFGGEEFVLLLPNTPWP
VGVRIVEALRAAIEACPFHFKGEPVTITVSVGLSAFKAGDRSDLVIKRADQALYRAKDAG
RNRVEAG
>A0A5R9LE64|diguanylate cyclase|EC 2.7.7.65|Klebsiella indica|TrEMBL
MKDESQKYIALIFKEWLPLYDSLTPEVKSVLKNIAGQQAEALATRFYDFIFQDPDIARYL
TYDLVQERLSSSLAGWVKDLLTCEKAGLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIETIRDSAIDRETSIAAIHYASMAISMAIEMMCHAYTLSHSRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKTDINSTLLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLINKVDTLLSAWKASVEGSDYKNTQSLLQGIHIHCQQIGSQLAVLFSSLTQMQGG
KDALTSLLNRRYLPVVLKHEVALAMNYELPMTVAIIDIDHFKEINDHWGHMVGDRAIKLV
AELISDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILDRLRQKISQLAFDVGAESEVSL
TVSIGYAAHTGHPDYNLLLRDADSALYVAKRNGRNCVKLHEGDSGH
>A0A0T9LDE3|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MSSIKNKSVGQIKNQTNAQKLPTLGRVLGRVHLIVALVSVATAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDTDAASEALAIIAANEEVAEAKIIDVNGRIVAQWTLPND
GPMHQLEQSVARWALPEPVVLPIVHSGNEIGTVVIVGHGGSLLRFLLQGLTGLLVCLILS
TAVALFLSRRMLRRITGALNRITEVAHNVSRHRSFGQRVPSAQIAELNELSQDFNGLLEE
LEIWQEHLTRENDSLAHRAAHDSLTGLANRAFFEGRLNRIINDCKTSQHAAVLFLDGDHF
KEINDNYGHAAGDVVLTSIADRLRALLRESDLVARLGGDEFAILLAPIHDTDDVLTIANN
IIKSMAHPIVLADGREIVTSLSIGVAIYPDHAQTPDELLQRADEAMYQAKKGFRLYEQSI
VYLSDFLYSENKYPEITHTENLG
>A0A0T9NR57|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MNYNQSDHKLKIADLNERVVHEILEVISDGIWDWNANNGFVYRNTGWYEMLGYPAHAFEN
TVHTWEKIIHPEDFERVMFQFDAYINQQAEKYQIEYRCLTHDGDYIWIEDRGKVIERNID
GTVSRMIGAHRNIHDRKHRLEKLELKNKSLEALVKERTAELRESNFQLQQQLNIEKILSE
TDVLTSAANRYLLEKVLKHEYNRAKRFCQPLSLLALDLDNFKSINDKYGHSVGDLTLTHV
VDVISNNIRAVDLLGRWGGDEFMIVLPNTQLNEAKSIAEKIRHLIERMPVDGDIHVTMSL
GVVELEQKESQEQLLIRADKMLYNSKTAGKNRVSG
>A0A1K2G1Z6|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. F-1|TrEMBL
MTSVDTHVIAAGLPALGWALHGGLLTRRLSTARRDPLTGLHTRAGWTTRAERLLTKHPDA
LVVLVDLDDFKAINDTHGHAAGDTVLVATARRLADWGDHHGIAARLGGDEFAAIVTDPAH
TTGLHALQGALDQPVEHHGRTLPVSASVGSCHRPDLPVPSLTDALSAADAAMYAAKGHGR
RNTHH
>A0A345CGP4|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. W17|TrEMBL
MNKKYQRVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTFLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSVGNIFATWLIFSWDAINLWYTGINIVEAFVGALLLRKLLPGYNPLQN
LGDWIRLAIGSALIPPLLGGVLVWLLVPSDEPLRSFMVWVLSESVGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTMVVTLLLSWIALHFLPWPFTAIIVLLMWSAVRLPRLEAFLVFL
VTVMMVSLMIAKNPVPLTTQNVGAMTNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSVIGMALVSTDGQWLQANKALCQFLGYSQAELRSLSFQQLTWPEDLESDL
EQLDQLLQGKINSYSLEKRYYTRSGEVVWALLAVSLVRHADGTPLYFIAQVEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDVKPNVISWDKRMFELYEVPPHVKPTWQLWHECML
PEDRAMAEQVVRDSLAARVPFKLEFRIRVKDGIRHIRALANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVNMNVTFMNPVAEKMSGWLQEEALSQPI
LSVLHITFGDNGPLMENIHSGDMSRSDIEQDVVLHSRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRELSYNASHDALTHLANRVSFEASLKRMLHTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSTDMLARLGGDEFGLLLPDCNTESARYI
AGRIIDAINGYHFMWEGRLHRIGASAGITQIDESNNQASEVMSQADIACYSSKNSGRGVV
TVYEPQQERMLNAPGAISLDEQWHMIKDNHLLMIARSVASPRIPESSTFWMLALRLWTND
GEMLEEQAFRAGLAEPELIHALDRRILQEFFRNFATPLTNKGTGVALPLSMAGLASATLV
DELLEMLRACPLQPRLLHLIVNVSVLTQEDDNTHYNLQKLREAGCRIILSHVGRDMEVFN
HLSAQMADYLLLDPELVANVHGNLMDEMLVTIIQGHAQRLGIKTIAGPSNQPIMMDTLSG
IGIDYIYGNTIDEPQPLELLLNTSYFGIN
>A0A1V6A023|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin155|TrEMBL
MDQSEMGKAAVEFSKQQRRRKIATCFVLSGWYATLFITDNLFGYHPAVRVDGALALVFLA
CAFGTAFMTSWKKRSLLGLSAIAGLLLISSTPLLFTVMGLPLSILLLRHVMTLFFCVMVA
PYFLKPRGFAFFLVLLYNALCFYYPILRTRELDETMAYVIVTYSFSLLFAYFFLDILRMN
LDHVSSLIAAKRDAEDRALRDDLTGVYNRRYCDNLLRVLIENETEKALLFIDLDDYQNVY
QAHGHLVGDAYLKRSAEAISESIRSGDVVSRFSGNQFVVVLDSNDLTLAETVARRIIKAV
GNVIPEFEGISVGVTKIIPGITQQAVLVNADTALYRSKRSHLVGISIVDPANPRIEPELW
PETDMTPQ
>A0A1V6A1Q2|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin155|TrEMBL
MTDVCDWLKERDLEGVCGDILEQISMPLIAGSIVEERLVVESVNGFFGDLIGTACLELPE
ALDVLLSGLPGPKDLEPLLRAVMAKGWKTLCWALVPGEMELDLSCWSDGEHFVAFFHDLS
PHEFHRRLLGMGERLTQALGLFDAKGTIPQLLLELVKHMGVDWAGIFVWDGVGQRWMLSL
EEADPGEYGLGEKQSALTFARKLSEAQGGPFGHQFGGLAIQEGSKWWVPWACEGREWEPL
MTEAGFGSLFCGVLLTGSAPAVLLCLARAGGVFAKINRGVLEALWPVFLSSAERNRAVEG
ITRLYPRDPVSGLFARDMTLGLMKVEMDRSRRYGYPLTAMAVEITNLDRVWATGGEEAVA
ETVQVLSREVLKNLRSVDIGGRVGDGRIVVLLPHTPLEGAEVVSGRIRSRLGAISPSQSL
SVETEVRIALRSDDCGEPEDLLARLGFTGDGQGFS
>A0A0T9LER2|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MVVTDLDTLNILSTPIWVVLPKNQEILFANKEARKIAGNNIQLPLVRYGRFSAHAQQNLS
AYLPALAVDDHIVEIWTIQAEKNIFPLSCRLSLTQLEPYGAVIIFEGLYISESVVTQPTS
PRLLAKSYSRGEQSFYEQFFSTNTAPMLLIDPSKEGLIVDANQAATRFYGYPRDEMCRKH
TWEINSMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCI
IHDITEQRRLEQALEHAALKDPLTDLGNRRQFFPLVEHAHAQSQRYGQHFSLILLDVDHF
KSINDQLGHHKGDEVLIFLARTLESIIRECDIVFRWGGEEFTILLPSTNLDGALQLAESI
RETIEMICQPNLPQLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A0T9PF06|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MVITDLDALNILRTPIWVILPKNQEILFANKEARKIAGDIQLPLVRYGRFSAHAQQNLDA
YLPALAADDPIIEIWTIQAKENVFPLSCRLSLTQLEPYGAVIIFEGLYISESVVTQPSSP
SPLAKPYSRNEQSFYEQFFSTNTAPMLLIDPSKEGLIVDANQAATRFYGYSRDEMCRKHT
WEINSMGMDVLPVMNEVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEEALEYAALKDPLTDLGNRRHFFPLVEHAYTQSQRYGQNFSLILLDVDHFK
NINDQLGHHKGDEVLIFLARTLESIIRECDILSRWGGEEFTILLPSTNLEGALQLAESIR
ETIQMICQPNLPKLTVSIGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLVA
>A0A8B3UM52|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MLANSRCLKGRYISFCFGCLVVIGILQALFSKVVEWVPSFSPLLFPTLTIFLLVFHMFIA
CFMAMKYWCDKRRLYLIAIAFAFAGSALLMVGTLSSFPAWLNLYQFNVVNYNDAMIYFMF
RHFLMAVLFIVAAILYPTRDYPFSRLAHISIVSGAFLFTACVVGLAWIYSSHSPLLSIDL
VDNETRQFMVLWSQCINISLIVFWVVSLVTLMFVTRVRNLFWVGGNFLCVCYIVTLAMLL
VGGHAEDISWYRARLFETVATLMIIFVLLYDVFMLYRDSHLKYQQSYQNSIRDPLTRLYN
RSYFYESLNQALDMAKPSRPVSVIVSDLDRFKRINDNYGHLQGDKVLQFVANLLMDSVRP
QDIAARIGGEEFVLMLANTSSDAAHQVAERIRLKLSSFDKTSSGGQLPEPITISMGVFTA
TSSTVTAEACVESADKAMYEAKETGRNRVVVFK
>A0A8B3UPH8|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAAAEVINAHKKRFAYWSWNPEDNNDTLGALVSRWLFPVPVAQPIMHNGLTIGE
IRLTARDSLISHFIWTSFAVLTGCILFAAVVALIITQSLHRGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMMEFGDKRHQ
SYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENT
SVEALLERADRNMYQVKNQRTKTIS
>A0A0P1FWR1|diguanylate cyclase|EC 2.7.7.65|Thalassobius autumnalis|TrEMBL
MPLFVFVDAAGRIRQIGPTLEKVLPGAAQRCDAFAQHFAPKYPQRHAVDQFRDLAPGSTL
HLCLRSYPQIGLRAVVSPMAGGTLLNVSFGASIAEAMRCLDLRLTDFPATELAVDMLYQL
EAKSAAMAASLRLAQQMRGARDAAEERATTDSLTGLGNRRAFEDQLNRLCSNGDPFSLML
LDLDHFKQVNDRLGHPGGDYVLQQVAVILRQELRQEDTIVRLGGDEFAVILNDIANRKRL
RRIAVRLKTRLQGQMSFEGQNCRVSASFGLLCSCDVDVAHPQQMLVDADRALYASKRAGR
GRVTFHKREIV
>A0A0Q0FBC0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MSSEDKAANLSKLAHQNKRLRTLLEKYKQSHHLQNALIQLSEQASSVAELTLLYPAIHDI
LQAYLPSKSFYVVLANQYTHALELSYFCDEKDGISVALNQDNSFEEGATGYVYRLGKTTC
FTKQEMQSAAQNGLFKALGSPAEHWVGVPIYQEQNIIGVLAAQSYDKQQDYSSQQVHLLE
VMSLYLATAIERVKKRELLESEVKIRTRALTQSNEALNLEIEQRKRALQRQQILFKISEL
ATQAQNLDDAYVKIHQIIKTITYAENLYIALYNKETGWISFPYCVDEFKDNTEPRKFAKG
YSELVISSEQTQLIHPSRAKELLESGDVQRNNPIPEEQMATSWLGAPLKTSQGVIGLIAC
QAYNNKHIFSKDDCELITFVSHQIATVLQTKLATQALKSSHQELEYRVNEKTKALQQANL
HLQMQIDERKKVEQQLYHDAHHDSLTGLPNRSLFLTQLEKTLQHYHRFPEHHFAVLFIDL
DKFKDINDQLGHHAGDQFLISVADLFSHCIREHDLLARLGGDEFVILLTHLTELQQAEDV
ADRIINIMKKPFCSKGTCVQSGASIGITYSNSSYQHTDEIIRDADAAMYYAKNAGRDRYE
LFHPLLTQTLTSAESPAQHHLDSLPMSFRSADIINLDEQQQSESLFEAFGEHPVLGYTSF
EVLKKFATDKEQHLQVELELLQHAYAHALAANVAMVLMPCSGLLLEALEFNLFTEVLSKL
QGQSQLCLLFDDQEIRYACATQLENLKKLSQLGYSIGLNNFAKDRCELNALTDINFDYIL
LSSTFSKRVLQQESFNLQLQGVLAITQLKGIKVIAKGPSILNFRALLDKYGLSLFVAKQQ
GLSQSIEATENTAQSIN
>A0A8G1NIA7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MENQRGKGLSFARRIYLPRAIGLGIGFFSVGAAVYPLNMPSWLWTLLLFNGFLWPHVAYQ
WSTRSAFPYRAERRNLLYDSVFGGFWTACFQFNPLTTVTILSMMTMNNVAAGGVRLFWLG
ALAQVIGVLLGWSMFGVKFTLTATQTQVWACLPMLTLYPLALGMVCYRLAIKLAEHKRTL
SALSRTDSLTGLLNHGAWKDLLHLKFQQCRQHNSQAILALIDIDHFKSINDSYGHIVGDA
VLRQLSHELKFVLDGSELAGRYGGDEFCVILPNLPLSKAEALMKQLRQGMDRYRHPDVPE
LRVSLSIGLARYQTSYADALEWFEDSDKALYTAKHTGRNTISVALSRSPA
>F4V1Z8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA280|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1V5RMA3|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin315|TrEMBL
MIRLTKGVFYDLAIWMMGFGMLVGVVFPFFMEFLGMDPSTVYTVWFFSVCIFSGLLVGAV
NILLAHWVVGSRLNMLSTHMGKIEDKLHMISGSDTMVDCSAQDCHLLVDSTDAIGRSSAS
FNSLVDTLSSSLQLEMQIRSYTRMLTTHLEVEALCQNALSSLLELFNIDGGAVLVEIKGN
LKLLGSSGLANGEELGKNPQVLDTLSQLNRKRIDIPVQAEIDGVIARFRPQTVLLFPIIY
KGLGMGVVILAAKHSIPRDVEKNLDLFISSLALALHNAVTHDQIQRLAAVDPLTGVYNRR
FGLTRLREEFIRSVKQNTTLGILMIDVDHFKDVNDTYGHTVGDRVLQGIASSARTQLREG
DLLIRLGGDEFMVVLLGASGNDVLEVGEAIRRTVSERTTSWGEQQIKVTVSIGGASLATA
NVKDEQDLIDAADKALYQVKESGRNRVGI
>A0A0Q0FF31|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MCLCFGFVSLFFAAFNIIVNNFALLGYLEIALSVFCAYTYYRLNTHALEVWQSVVMCIFV
TFVIVLGNYLAKPINGVYVWSFALPILYYLLLGKRYGIVLSALLFVLQGAILVTKSSQLP
LTTLNFSLNLAFVYISIWAISHVFEGSRALSSKRLKNLALLDPLTGAANRLSMNHYFEVE
LRDKSQLYLFLLDLDYFKQVNDTYGHAVGDKVLIEVATLLRVLLAKGYVFRVGGEEFALL
HSFTSQNDALTMAETIRSKLNNTALDIDGLNIKVTASIGVVKYHQGDTLEKFVIKADKQL
YKAKEFGRNKVYFQSSAHLNEKPQVA
>A0A3F3C1C9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHFNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1V5RL15|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin315|TrEMBL
MTVLLENDLQNGFEGANYGMSKIHTGMVLVLAVLIIGVLVPTWMDVSNIELESIWDGEAM
NLREGWTLSADGVVLDDDFTLPRIVKDPDLSDKRVTLSRTIPSSYTAIRSLLFRTSQKRV
KVYVDDRLTYSYDANIDNRRIKLIGLINHFVRLEEGDQGKTLNIEMISNMPKSSGQFHEV
YFGTRTAQIRRLFNYDGFSLVVGVFLIINSLATAIIASRSLRNGKIYRGTLALSSIELCV
GLWVCCGSMSTQLFIHNQLLLVVLAMTALYMLPVCVTWFVLSMYSIPMRRFFMISTLFFP
IAFVVVSALQLLGVITYITVLIPLAVLFFFYLLIILGAVMHAYRKGEKNAKPFLVATGFL
FVSTVGELTLLILPHPTFINIQPLNIGVLIFGSILYSQILTQGVHFLEERGRKEYLQSLA
YTDALTGLGNRRAFDEELIRLAKSDSKEKQYGIVVFDVNSLKQINDDYGHAEGDLVLREI
GELLTSLYGTFATIYRIGGDEFALICEQCGQERMRDFERLFTEAIAKKPFTLAFGSALSS
LDRSDSSDSLYKLADRRMYQQKKTMQYKTYHKSPQNPASIDTSEGTR
>A0A377YV16|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKYEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDASLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDVLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEEIHTECSAIM
QDADERMYEIKKGKR
>A0A1V6EGX5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin099|TrEMBL
MKKVNEITFFILIAAIFISTFVLTDVLDMPNLYLIDREGVSFIDGWTWKGDGYKERYYLP
HRFDVEKSEPLVIRNTVPDRFPAGSVIALKANVQSVVIKIDGETVYDIGNDRSKFMGRDL
GNYWAVVKTQSEHKGKEIEISLFSHRAASHGFASEVFIGSESAFYGYLFAQHGLWNIFPP
IIFILGIMIILTFFFLGMYKEKNLSLLYLGIYALLMSNWFLGDSEMLQLFTANTYYSTRI
AYLMTLVSPIPVSLYIREAVPMKKRFFDDFLIGLIIINTVVSLGLEHSGILGLSDTVLVA
VGLISVMCVYYMAIFIIESVAYKNEKALRELKSLSVIFIFAVAEIISYFVNGQIVSSLYL
RIGVLIYIVLVLIYQVKDYRERRRIRLEKEYYEKMAYTDAMTGAGNRARFMEDMDMITKP
ERVIIVLADIDRMKYINDYFGHFSGDKAIIDTYNTLNTNFGHIGRIYRIGGDEFVVIVEK
TNINEIYAIIKNLEKEVDLIDKESEYDFSISLGVAEYDASLDEDIHATFLRVDHSMYENK
KKHRTAIPAKMPDNQRMYQDHT
>A0A1V5HK28|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA124|TrEMBL
MMALQNILIASSNNGIVLEEILVANAIGLLVLIVSLLSRVEIKKERHLSGKIFDGMVWIT
FFALILETVTFLLDEKPGALVHFLQYATNTYLFLASSLVGILWVLFVDIRIFRSSTRIKW
WLKFLIIPYIALIVLIIFDYFGADIIFSITEQNKYDRGKFVMLTFGFVFCCYFITLALAV
LAVKRDGHIRFFPVHYFVIPSLLGTLVQGMFYGLAAGWLCLSIALLFVQLHLANQNAYED
ELSGLYNRKYFGWMIEKLAKGKKNRFISAIMMDIDRFKLINDEFGHSVGDDAIRSIGKLL
TDITSDDVIAFRVGGDEFTVLHIGGTEADIEQLTFIINERISDFNKTAKKPYSLSVSMGY
STCQTTGTSLDFFFHQLDQKMYEQKALQYAKNQK
>A0A7S4H0E9|diguanylate cyclase|EC 2.7.7.65|Serratia sp. Tan611|TrEMBL
MLSKHGLPGAVRLVNLFLLVFFLSLVGIFSRPLDSLSLFWPVNAILLGVLLRKPAYASPA
GWLVTYIAMIAADLTTGEGWMLALWLNLCNMSLVATGYCVMRLLPQSQRRMGNPQAILYL
FAAGLAGAVVASTLSILRNDSLYNNTVLTAWLAWFSEQFSTTLLILPVLLAAPRLKTLLR
MQYHWNLSDGLPLLALLGSLLFSIYIGGPGAIAFPIPALLWCAVRYQLFTVTLLTLLTGV
VEICTISANVMLYETPTSRGALLDTLMSARLGIAMLVMGPLILSSSMVANRKLVRRLEHS
GNHDFLTGTLTRSALTRKARELLEHKRRSKEAVSLLLIDIDHFKLINDTHGHIVGDRVLT
HVTHVLRRELRHDQPLGRLGGEEFAVVLPRALAAQAVALGEFLRQQVEKSEVKSGHKALK
VTISVGVASLAMKEVKSWEQLMNMADIALYRAKSLGRNRVESFNVVSGSSVDHIWFKE
>A0A1Y0EF65|diguanylate cyclase|EC 2.7.7.65|Yoonia vestfoldensis|TrEMBL
MEKIINLLAPRNRLGVVLRVVLFTIAIGLANMVFAVTIVPRLPDVPLVYDLTRALVVGVP
FLWLFFAVMLHQVRLQRRLSFLSCRDWLTGLNNRRTFFDLATLRTQQCKTGILLMLDADH
FKQINDTYGHQAGDSCLKAIAYMLNRNLRTGDISGRIGGEEFAILLADTTPDHARVISER
LAKPIPFRAGPAHLTVTLSIGAVVATPDTPLDVLFSLADRALYQAKSEGRARVVFAEPVF
DTTQIRLAV
>A0A811GD78|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MQILLTSSRSISAQQQLHAFFITASIIFICCLCGILTRPVTYLAYLWPANAVLLGLFLRY
NHLKVSGGWLGAFTGYMLADLVTGNHFQLTFILTLSNLINVIVSLFFIRYWKLNYRNYNQ
GFTFLYLFTICALGGCLASALFAVSTIPYMPNTFMSTQRLGIDFGMWWAGEIVNCITILP
LILFLPTTIEEVRKNFKQISLRKLDYTKFLPLLAILISVSFTHVFVGPGALLYPLAALIW
AALSYPIFTVAIINSIVCLVTYHSLTDFYLLDSSNAYLTTTISVRIGLCMLGFAPLILCI
ITSNRRELYKKVLRLANYDSLTNTLNRRHFFEQGEKYLLDQKNNSISLIMFDLDHFKKMN
DQYGHHVGDLLLQHFSQFVQDNIRTNELFARVGGEEFLILIMNTTLQESHAIAERIRLKA
ELTPMRLNQDELLFITTSIGITHHSLPTEVSLQNMINQADQALYQSKTLGRNRISIAS
>A0A485BHW2|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLYNIRLMLCIVHDVTEEVHLRRELEFSASHDPLTGLLNRREFYRIVDSAAFKPTGFCLL
LVDVDNFKAINDSYGHQKGDEVLLTISRILESTVTHQDKIYRWGGEEFLLFLPERSIEMA
LQMAESIRLAVSGYQLADHPGPVTVSIGVADHQDDEEIDQLFNRVDKALYAAKKEGRNQV
RLYLVEKY
>A0A839WPG4|diguanylate cyclase|EC 2.7.7.65|Atlantibacter sp. RC6|TrEMBL
MSKKKQQHAWRIRHPIKIVNFCFLVVFLCSTLLTWREIVVLQNGWTASQKNRIQSVAAAL
DRHLQYSVDKLQFYRAAMQHALSSPISTNRTDAALAQFDQQRQSGAWQIRLDTQRGLPVS
GISDDRVRQNPLLARDEQRLENELIAALEFGAILQLADPQQDRQRRTFYTSRAGFYLSST
PHAASDDIASRYHRLVTRPYFHRHTQRNNPDRGVRWTHTREANRQEDQVITASLPLDYQN
QWYGVLAMDFSLGTMNDFLNQAMFRRDSGEILLLDNQFQVIASSAESVPTGSLFSQSERE
QLTREMAEHNEGGALIDTRYVSWAKLNFFDGVLIRIYSLKQSLSGEFGSILLVLGLLWAL
FSLMLLGSWYVIRRMVRNMFSMQETLQWRAWFDAQTHLFNRGAFIERAKQIAQRCQQQQL
PLCVIQLDLDHFKRINDTWGHQTGDKALSHAASILRQSLRGDDIAGRVGGEEFCIVLPGA
LLPEAVAIAERIRERLSSKEILVRQNTTIRISASFGVSCAVLERDYDFEHLQSIADRRLY
QAKQAGRNRVSSSD
>A0A839TZ35|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium trifolii|TrEMBL
MTARILVVDDVPANVKLLEARLSAEYYEVVTASDGYQALEICENSNVDLILLDIMMPGLD
GFEVCRRLKSQASTAHIPVVLVTALDQDTDRISGLNFGADDFLTKPVNDLQLLARVKSLV
RLKNLTDELRLRVATTRDVGLESILRFPIGSEGSAKNARVLLIDERPESVERIQRILADE
GVVDVQTDPQTGFFDAIQGNHDCLIISSSFTNFDPLRICAQLRSLDNTRSLPIILLADRG
EEPLIRRALELGVNDYLVRPLNPNELLARLRTQLRRKAYHDGLRASVVKTYEMAVTDSLT
GLHNRLYLETHLATLFKRAVERRRPLSILMTDIDRFKLINDTHGHDGGDEVLREFARRLR
RNVRGSDLASRYGGEEFFIVMPDTDSALAAVVAERIRREVAATPFVVNQNGTGAPVTISI
GIASVLHKEDTVQNLLKRADDALYGAKAAGRNRVVSAAA
>A0A399ETY6|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MVGLEGFLDSPQVIVWLDSQGRIGWANRLAREGASRLGLEEHHVPSLLARREGPLRLVDA
KPPATHLPYQGHCTLLVEGKPRRWYRFFCQPYAGGTLCFGVDVSDLYSKALAYQTTLEVL
SSLFTRETRLEDMLQHVLQTAVEVVPGAQAGSIWYYTGEQFRLAAQVGFSPELLGVSIPY
EDELKWYGAGAEAWRQGRPRLLQGSEAILRSVQAMREGHNREAGRVGELQANLCVPVVMG
GETLATLNLDNLEHPDAFPPEAVAIASHFGLQAAVLLYGVLNRRSLAELAHTDPLTGLGN
RRALGEGFARIRAQAQRLGKPVTVIFWDLDGLKRVNDQHGHATGDQVLREVALALQTLLR
HGDRAYRIGGDEFVSLHLDLSEGEEHPLIERVRAALPLRISAGATRVFAPMSLEEVLDQA
DAQMYRDKPPKR
>A0A3V9NI42|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MFPKIMSDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRHHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W6F5K8|diguanylate cyclase|EC 2.7.7.65|Methylobacterium brachythecii|TrEMBL
MSARVLIVDDLLPNLRLLETKLSMEYFDVVTAMNGPEALAICAKGLCDIVLLDVMMPGMD
GFEVCRRLKTDPATAHLPVVIVTALDEPSDRLRGLDAGADDFLTKPIDDTALFTRVRSLL
RLKAVQDELRTRAMASRELGIGDPFALAAAETGQGARILLVEDRPSAADRMATALRQHHT
VTIESDPQRALISATEGDFDLALISVDLNGVDGLRLCSQLRSLDRTRDMALIMIGETHGM
ARLTRGLDFGVHDYLLRPVDRNELIARVRTQVRRRRFSATLRDAVQASIELAVTDELTGL
HNRRYLDRQLGPLFGAATAQALGLACLILDIDRFKSINDTYGHEAGDEVLKAFADRVRQH
TRGIDVVARFGGEEVVIVMPGATLADAQAAGERIRDRVQCLPFPIQRGTNLINVTVSVGV
ATRHTSDTSASDMLKRSDDALYRAKADGRNRVVAEAA
>A0A850F5D1|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium BIT-l23|TrEMBL
MVNGCKTNTNINEIDRALGELNLAIKNHYEWAGKLLRLELLGGEPDDDLIHIESHKRCHF
SYWLAAQAEMDDLQVELISEINRWHEIVHHQARLLINVIIASTVTSELLDDYLKAQQEFI
QAIDSYKVYLFSLRNLHDTLTGLPLRQMLYSDFALRRQRCRREDKQLWLLMMDIDRFKRI
NDTWGHNAGDEVLRSVALTLKAGTRCKEGIYRFGGEEFVMLLEADNEREAARAGARICRY
LEQRPIKRDGEEIQVTVTGGLTPILEDESLHEAIGRADKAMYFGKTTGRNRCIVTGPKGE
FINVS
>A0A1Y5YTU0|diguanylate cyclase|EC 2.7.7.65|Bacillus pacificus|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEEFSFWQKCVVGLLTGILSILLMHFGVHIED
IMLDLRYLAVILAITIGGPIASSITVTIILITRLFLTEYSLASELACYTIVLIGVGIIFI
WRMKASIFTRWIWFNIYSLSILVVPLSILFKDRSIVVLYLVCSSIAAYITFISANYVLQS
NELFQKMKQYATIDALTGLGNVRQFDLEMNHHIGNKRMKNDSLCLLLIDIDHFKCVNDTY
GHPAGDEVLKQIGSILREVSPFPNLSFRKGGEEFALLIPKKGLAYGMHTGEKVRTAVENH
SFELLNGTKIKITVSVGVSVYEESPEQFIQAADDALYYSKRNGRNQVSSAS
>A0A1A8XK72|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MAEPACPRAPDAQDLPPSRQSAQSVPSVDWPAEVTRLNKIIRVLMDRAERSTSVQGSDFS
LFQTAIMLEEQVRQRTVELEAALRENERTNRSLRESEARFRAVVNQSLVGIVIIEDQQFS
YTNARFNEIFGYEDDEIRALGPLDLVVESDRPLVTEHFRRRLNGEAGPVDYVFHGLRKDG
AVRDIESHCRGMDIGGKLLLVSVVMDISERKRAEREVQALQQELREQSTHDALTGLYNRR
YLQDTLGRELLEAKREGRPVSVILADLDHFKAVNDRHGHLGGDEALRVFGALLKRHARGS
DIYCRYGGEEFLLVLPGMTAEIAVERAEQLRVAIASAPVNHGGSLISVTASFGIATFPRD
GRNGDELIAAADRALYAAKAAGRNRVNVSVGATTSPAGQHGAGPG
>A0A5C6AFX2|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MPVGDHQEGKSGTSDTTEWGSWIEKTVTTPSFRYDALRYRLGLRRLTTDRVHSLNCNQEL
TERFQRWNCAARSVLIEPKVTCPRLFRHSSLFKAIFASFRLAFALVCVGLGLILGAQWFG
LIPDSRVQIERARQSTCQNIAIGVLDDIRHERWLKIDGMLQAIVKRDEHLLSVGLRTDLG
QLRVATENHEQCWQTIDHESKLVDDPVDDVPEWARPSASPNHRDRRTTTWVTPPEASDGA
RGDASITSATSLDRHVCLEVPIIVRDLPWGNLEFCFRDTSSGLFGNSLDAGITGFILFFS
VCGLGSYTLLMMRIMGVFSRTQVVPDRVRQALDTLAEGLLVLDGDGKIVLANENFLQING
FESDELIDRLAADLPWFFPSTDPRKADARDAFPWTRAIKQRQSVTAEILRMTGRDGVHRV
FSVNAGPIGDDSQQKGALVTFQDVTHVEKHRVELENMLTMLRRSKDEIQKKNQELEILAT
RDALTGCLNRRAFFERMQPLLEQYRKDARPVSCFMVDVDHFKSVNDTYGHHTGDEVLRAV
SKQLREIFEERHIVCRYGGEEFCVVLPGLDLDEAHEEAERTRLAIMNIRLEDPAELRLTA
SIGVSETRFGATETQDLINQADECLYVAKRGGRNQSVLFDPDRVSVLGEEEPKTESIADP
DLVKLPFNAVNALVSALAYRDPTTAEHSRRVANMCVKAAKGLLCQRDTYVLEIAALLHDI
GKIGIPDTVLHKPGPLDENEWKIMRRHNSVGIDMIAGTFHCAELENIIRTHHSMSAERQS
SRKFDFESTPIASRLLNIADAYDSMISDQAYRRGCSPEEAIDELRRNSGTQFDPELVEVF
IRETITDRRESRMGFATSRGIAFVVSRPVAFQIGQQIEQLADAIDKQDIETLKRLATELN
HIAEANFLMPMVECTSRITTAADASDEEIQWVELLKETQTLLDLCRSTQNAHLAENPQSF
A
>A0A4R0GLT8|diguanylate cyclase|EC 2.7.7.65|Kosakonia quasisacchari|TrEMBL
MYRSTEQIDNILFDLNKAVDAHYDWLINMFASVVNNNIEQSQSINAHSHHLCHFGRWLDG
HQPANSEESACLQAIDATHTKMHNCGRELMCIIRDKKTNIDKFSEFKHRLALFSAAVTAY
KTYLLKMRGGVDILTGLPGRRMLDERFELQLKEVSDQNVYMLLLDIDRFKNVNDTYGHLV
GDEVLRELAQQLRDRIRGGDTAYRYGGEEFIIILQAPSDREACQAALRLCESVAGTTIHC
DDKALNITVTIGVTQAWAGESIGIVAKRADAAMYRGKQTGRNRCMFMDEGGEIHLITD
>A0A6M2A9I7|diguanylate cyclase|EC 2.7.7.65|Chlamydiae bacterium|TrEMBL
MSLKTLHFLLVEPSPSGQSEIEEMLSIFSNEVHKIEWIVIEEALAALELLKTTHFDLLIV
SLPLFIYPRRTLWKELHSLAGATPILTIGEQRDEKTSTLAIHLGAEDYIPKSEYSPTHLW
RAILHALERHKMHEKFKELLFADELTRLYNRRGFLTLLTQQISLSKRLNKGFLFFQVDLD
ELKKINDTHGHFAGDSALKGAALCLKNAFRKQDIIGRIGGDEFAVIAINAPEEEGDYLKK
VVHESAHQYNLAHKHPYLLSLSVGAAFYSPQEDPSPEELLAQADADLYVEKKQKK
>A0A1A8XMZ0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MNVSIFQWRWLKTRITFFTLAIFLTSIWSLAFYTSRVLREDIEQLLGDQQFSTVSFIAAD
LNQELGGRFEVLAEVAASLTPDLLSHPAVVQKFLEGRLLLAARFNAGSFVVRLDGTAIAD
VPLSSGRMGVSYSDQDYIVAALRDGRATIGRPFIGKGMKGPVFVMATPIRDRSRQVIGAL
CGVTSLELPSFLDQLSKSSYGKTGGYVLVAPQYRLIVTATDPSRVMATLPGAGINPTIDR
FIAGYEGTVVYVSAVGVEILTSSKRIPVVGWDMVAILPTAEAFAPIRAMQQRTLFATLFF
TLLAAALTWWMVRRQLFPLVEAANMLAAVPETNEPPQPLPIARLDEIGELIGSFNRLLAI
LAQQEAALREQKEFFRLIAENLDGFVAVLDSEGRRLYNSPSYARLLGKRNISGTSSFADI
HPDDRERVMGAFRQAVATGIGQRLEFRFVMADGRIRLLESRSGVIRDDAGRTKRVVVVSH
DVTERKQAEDKIHHLAFHDALTRLPNRLTLDDRLRQAMVASKRSGCYGALMFIDLDNFKP
LNDTHGHEFGDLLLIEVAGRLKSCIRETDTVARFGGDEFVVVLSDLQADEAESTAQVRTV
AEKIRATLSQSYRLTITRDGKPDTSVEHQCTASIGVTLFISHGASPDTLLKWADAAMYQA
KEEGRNRICFNQSQC
>A0A549UEG4|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
MNKGPSPIKRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RTLEAALVFSDSVAASETLAALGQQGQFSVAEVRNQKQKVIATWRYDAQDTTDKISSIIS
HWLFPQPVTQPILHNGDVIGEVRLIARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKNLRAERIIKK
>A0A174GDY5|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MKRKTIGVLVGGITDDFTRLLCHGVIERAKTLDVNIVVIPGKFLDREYPETSDIYYEYQY
QTLFSYATKENLDGVIVASSCIGCFATKERISEFMKRYLKMPCVIVAADEPDQICVRYDN
GAGIREGLNYMIEELGYTRIGMIGGPDSNYDAKERRRTYIEVLEAHGIEFDPGLYVEGNL
TSESKEVFRDILDRNPDMQGVFCVNDSCASGFYEELKARGILPGRDISVMGYDDIEWATQ
IYPTLSTVRADAGKLGSEAVNLMVRLIDGKQVESKILPTEFIRRDSFCKKGGSRKRSKNV
IEGYLSMNHMLSEQWEERNKTQFKMKTFIQKVLSFDRGNDRSYGEILGTMDWLDIENAFI
FLYKEPIIHLIGEPFELPDQLYLKTKDLKEKVSSVITVNQKVSSSNLYDFESLGVEGAGI
YVLLPLYSNEILYGVLLCDLTEGVLVNGEFLGNQVSAAVKMINLLKTNEEIMKRLEESMA
ILQKNNIMLDNLSKQDPLTGIMNRRGFFDRSLQLLKECEEQKRTATVFYADMNSLKIIND
RYGHDEGDFSLKTIGDILIKSVGDNGIVGRIGGDEYCCLVLGLKDSDAADAFAEEVYSSF
EKFNEHCDKPYKVSVSLGNCQIVEYNKKGLQNAMTMADEKLYEVKKYRKKDVVKVKN
>A0A549UX26|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
MSKQFQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGGSLNYTYTTINIIEAVAGAMLLRKLLPWYNPLQN
LNDWARLALGSAVIPPLLGGVLMWLLLPEGTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVLMVSLMLAANPSLLYTPKANVMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNNDL
EQLGMLVRGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPLHIKPSWQVWYECVV
PEDREHAENVIRDSLAARIPFKLEFRIAVRDGVRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDDAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHNTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
SGRIISAINEYQFRWEGRLHRIGASAGITLIDEKNHVATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQTHASRELLSFDEQKHIIAHNPMLMIARGVASPRIPETFSFWLLSLRLGTED
GDVIEEHIFRTGLVDPTLNHALDRRVFNEFFQHAATAIASKGLSIALPLSAAGLLSTELV
DELLAQLQHSPLPPRLLHLTVPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVE
NLKFHTVDYLLLDSEISASVHGNLMDEMWVSIIQGHAQRLDIKTIAGPVQMPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A1B1NJW8|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MRFCLILVSFLFSTFFSTLVSAKDKDVLIIHSYHQGFFWTDAFQQGLEEVFKHSQISTRV
MYLDTKRLQSASYLDQLYRLYKTKFSEEKFKAIVVSDNTALQLMQRLAPELGDTPVIFGG
INNYDPSMHQGLKATGITEDIDLLSNISLIERLQPEVKKIYVVTDYSITGDAVRQQLDKF
MAMYPDYSAVIEPLAPKTYGDLLAFVQTLDRQSSVLFWVYYRDNNGWITGKKDWQQLNQV
TGAPIYMVHDLDMGFGAVGGVIQSGHIQGQQTAGQLMKVLAEPNASLPVVQIGSPEIKLD
YQAVIKWQLGVDTESPSVFFNKPLSFVERYEEQLRFVVSLFITLAVVIAVLLYYLSRLKR
SEQMALDNQTLIEMVFDQSYHYIGILDQNGCIVSSNSKLQDLLYQQNSVSEKPIWFHHHW
EQNAADRIERYFLAPDESSNCQFEAEIWHPEQGSMVLELSLKPLPLHEHREAQILLEARD
ITSRKLTEERLFEREASLSHYYDQQPVMMITLDEQNRIQQVNRFAEQLLGYKENQILGHR
LKSFYVDDDASIPRQVLLQPKQVMKGVWRREVEYRHQNGHSLWIRENIRPLVESGHLLIV
GEDVTTLRQMADQLAYQAQHDLLTDTYNRNHFEIELEKALKEVESYTRTHAMLYLDMDQL
KVLNDTAGHEAGDAAIQFCASLLEEVLPYKAILARMGGDEFAVLLKDCTERDAKNAASSI
IAMLAEQAFIWDDIKLNLACSIGIRLIDHTATSPQMVHAQADTACNAAKEEGRNRFSLYC
QDDQDLRRREMEMACVNMVHNALNNDRLELFAQRILGLEQDDHRMHFEILVRIRNADGEY
ISPGIFMPASERYNIAHLIDKQVVRQTLQWLAQHPNAMDNLALCAINLSGHSMGNQEFID
FLLNELQESAVPCNKICLEITETAAMSNMNQAIEFFAQLKQLGCLIALDDFGSGLSSFGY
LKKLPVDIVKIDGLFVRDIDNNEMDHLMVRSINDLAKQMGKRTVAEFVENNQIIDLLIEL
GVDYAQGYAIGKPKPLAELVEELSEELNNESETFTTQA
>A0A5W2AEJ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Pretoria|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A841L6W4|diguanylate cyclase|EC 2.7.7.65|Anaerosolibacter carboniphilus|TrEMBL
MLNDLIINAAILVAFISVGNQVFRDSGLDERSPFLLRVLSGGISGILGILLMYYGMNITN
KVIIDFRNIAIIIAGTLGGTMSIGIAAFIIGLFRVSYYGISDSSIAALIVTFLMDIGVSA
IFRRQITMGRKWFLSVLYCTVISLIAIAILLWHDIPLLPTVVINYVGGTAIVSVVIYKYM
KYLQGVTQLFKTLKEESITDYLTGLYNARQFNRVFDEIVGKAIEDQKMVSLLLIDIDFFK
KVNDTYGHCEGDQVLREIGKILSHSCRASDMVSRNGGEEFSILLQDCSAAQAYETAERIR
KIVENHPFKLSDGIEIKITISIGISTYPENVKDLRKIIENADNALYEAKRTGRNKIIFQS
>A0A841KWQ8|diguanylate cyclase|EC 2.7.7.65|Anaerosolibacter carboniphilus|TrEMBL
MVNDLFINVLLLISFTSVSGHILKEVPESLINKTYWKVLIGIGGGILGILMMVYTIQVVG
TNTLLDLRALSMIMVSSMGGLISTIVTGFIIVLYRVGYFGINQSSVFAVVHICLYVVSFH
IINKKFKTYEQNWFVKLAVALVILVTTFLYLLRNIEGHYLMIFKFAIVVVCAGTLEYYLL
KYTQRSNALYRIYRKDSTKDFLTGLNNTRSFDNLLNISFNRVKENSEKLSCLMIDIDHFK
KVNDTFGHPVGDVVLREFADILKKNCRNFDIVGRVGGEEFCVLLLDCDRTRSFEIGMRIR
DAVKEHKFPIGNDNVIKISVSIGVATYPDTVGRLEEIMEKADVALYKAKQTGRDKVCENS
>A0A1E3WGM1|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MTNKNKTKRFSTLQARLKGMLLALSALLILANLYVFSETRQLARSYSEQQNQATWFLFQL
SKEFSSLVSVTPFALENDQYRQKAELSYELTWSRFDLLLNAKEADSFMQLTGAREFFSAL
FQRYISLEPELWKLTSKRQAMVLTNQLESIYQDMITYVNVNFRIKSPIYQQQMDQARLLN
QTQWFLMSLLFICALLVGYILHLESNYNKHLALTDALTKIKNRLAMTEDVNRKIESQTHF
TVCLLDLNGFKQINDRYGHHAGDIALQTLAKRFENVECHCHAYRMGGDEFALILPQQRQE
EMEQTLEAILSCFDEKITLSLETSVQLSASLGLASYPAQGNNFSELLKTADSNMYQMKFA
AQKRSIQL
>A0A8F6DL11|diguanylate cyclase|EC 2.7.7.65|Sphingosinicellaceae bacterium|TrEMBL
MSEYIQRDHKQLLEFLYACPIGLVEFDADGTVAMINPNAMKHLLPLAGARDPSNLFVMLE
GCAPELRNLFESYPRNSGTICDGHRIAVDIGPGRGGKDPKVLACTLLKLAPDRAIATFTD
ITVQVAQERRLKQAETWFASLINVVNDYAVLSITTEGVVLSVNEAFTRQTGFPVDQVIGK
PLETILNGDPASGSPCLSSRLRLAERDGWYLDESWQVRTTGERYWSQCLFAARPGDQGEA
VGGYFVVLRDVVRDTSETSDLRRVLWFDHLTGAANRTYFLQQFEREQRRWRDDRQPLSLV
LLDIDHFKSVNDAYGHPTGDIVLKQLTQACNALLRPSDVFARLGGEEFAALLPNTPMSEA
VVIADRLREAVASMAFIVDAAPLSITASFGCATATQECSTVEGLIALADAQLYAAKHAGR
NRVNAAADLMSTE
>A0A450CGX7|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MSILLKKAPKLAKHIITSFYINRDIDEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAG
QDEIPSCDINNDIFETVSEDENRCMVLGKYTVRTKENAQMILEVNQRCTFEIIEDRGKLL
VKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDS
TYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPDLPKALEDCERCFAKGPTYSSEY
RIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNIT
DIMFEYDIENDTLIKYQRVEIDKKIELENFETKNYSKLLEFGKIIHLDDIGKLLEVLHGN
LRETIEIRQINSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQ
RDPLTQLYNQRVSQNLIQEYLCSSDSKNNDALLVIDIDDFKTVNDTFGHLEGNEVLVAVS
KILLHNTHDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIG
IAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSTYE
>A0A7Y0LQS9|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MFKEIFLRTFPGFLIIRDSNYRITFINDNLKNLIKSYMQDNPLGMTNVEIAKKLPDNIAK
FFTDYHNIQLNWEKDYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKSYIITMANDITK
LYEENKKNLHYSITDPLTGAYNRKYLNDRFDMFIGDYIVLIDLDNFKMVNDYEGHNVGDK
ILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQIEALRENFLKVFSKYKY
LSFSYGVDTVKRNLKLTIVELDKKMYKNKEKKKKKFNKNNY
>A0A8F5F473|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MASKPASEYARETLKQIAARRLQPTPDNYQAIYDEISGELTQPAFPQMRLRQIARVMPGQ
TPGQQRLLAQLGAAIEAQDWAALQSTLVGYAALGVTPVPVAVADKPAESGTLDTVFAEHL
ARLIDNVGASLGEDDERVRQLGQELVAWLRQPMPALVETQKLLSNFSYRLSFAAEDQSAI
RATLLMLLHMVFDNVAVLSQDDAWLAGQAQALRDAAVPPLTLRRLDDVQQRLKDVIFKQS
EAKAHAVEAQRQMRELLATFIDRLAQMDESSAAYHGQLSDCAERISQVKDLQALRPVLQD
AMSATQAMAHKSQAMRSELHELRQRADTANAEIERLRQELERTSAQARHDPLTGALNRKG
MEEALRREVSGSQRHDAPLCVALLDLDNFKALNDRYGHAAGDGALLHLAEVARRAMRPQD
QLARYGGEEFVLVLPGTALEQGVEALKRLQRELTTHYFLSNEEHVLITFSAGVAQLAPDE
EPASALRRADQAMYLAKRAGKNRVVAA
>A0A212K0F9|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MKHSSRIALGYLVIAIVWIGVSDWMLAALLPDAYLHVSLYKGWVFVLGTAALLKFWLGAE
ENRRDEIEARLQAGVVTDSLTGLRNRAAFIDHLRHAVERARREGSRFGLLYLDVDGFKDV
NDTHGHAAGDAVLREVATRLRVVLRAAETAARLGGDEFVVLAETGGDFDALTRRVAAALA
APYLLSGTELPIRVSIGVARFPDDGADADAMLHAADAAMYADKRVHRGTAAP
>A0A508SYR8|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium ivorense|TrEMBL
MKKTKAPGSKAKAKTGSRTAAKTAKSAKRRKGAAGARQAGPGRSGTADTARKRKAAGSDD
KSAIRRLKAQLARAQARIEELQASAETDFLLDILNRRGFERELARSLSFIKRYHASGALV
LLDVDRLKPINDTYGHAAGDEVLKAIVAALSDQVRASDVIGRLGGDEFAVLLWNLSETDA
HAKAAALEEMIDDLSFVFRGSQVSAGASAGVAILTPHSDVQRVLDEADRAMYVRKAQRRH
EAP
>A0A5I0EZW9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kenya|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1I9YSE6|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sprentiae WSM5005|TrEMBL
MLRRGLTFKLSVLLACIGVLASGATGYYAYRANRTMLVNEAEHSLQTSTELLGQRIAVSI
DDVAADALVLATMPSSVIVAQTDDGIGPNLARERLAQVYSSFMLHHAEYLQMRLITRQHH
GLEAIRFDRDSDGLVRVKGDGLQEKAQFPYVFETLAFSPGRIYTSPISVNHESGTHAAQG
KPTLRLGTPIADARGAVVGVVVIDIDLAGMLRRLQSDLPSDYQVYLANEWGDFLVHPDAS
KTFGFDRGRRVLMQDSFPVTKQLFEQRQSEVLVNGLTGSGEAAGRVLAFVRRPFGGSEGN
RFIVLGLAKPLEDVLSGANQLGSRIIRMVLVFSALSVLLAILFARALTKPLHLLAHAATH
LFAEHAMHTLPLKRTDEIGVLARCFERLRREIRAQMDALHSKQSELVHLASHDVLTGLPN
RMLFMQKLENAIDEARFRREGLAVLFVDLDGFKQINDQFGHSVGDKVLVTIARRLKDVLY
AADVVARLGGDEFIVLIEGPRAAEVTPAIAARIMDALNETLSVDGNSMTVGASIGISEFP
HDSGNAEELLLNADAAMYAAKSGGRCAYLRYRDLLAARLDEQAEQARELARAQLAQAQAA
RDATEGREAEPTA
>A0A087BEH2|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium merycicum|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYEVSAAATGEEGLELFTHGGIDLVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSTEIDKVVGLEIGADDYVTKPYSFRELLARIRAVLRRNQ
NVQQQGPAGEDDVPLTCGDIVMQVGRHQVTVRGESVFFPLKEFELLEYLMQNKGRVLTRH
QLIDRIWGADYVGDTKTLDVHVKRVRAKIEEEPGHPKYLSTVRGLGYKIDEPAA
>A0A173SUE4|diguanylate cyclase|EC 2.7.7.65|Anaerobutyricum hallii|TrEMBL
MKSVLDIQFNYLTGMASYMGEGENLFCQENKRLIQSIVKEQDLDLIGIMKADGDTYYNNG
ARKNVKNRGYFKKVMQGQKIMSPPIESKVDGRTKVILAVPIYRNGKVTGALGASYNVGAL
NQMLFNDIYDGIGFSMIIDTSGKIISCDSGLSYRKIGINDNVYDFYTKSGEVAEKTMKSA
KANIKKQKSGILVLKEKNAMSYLAYEPLHINNWMLCYLVPQSKAQEEFQFIGNKEVILFA
VIGVGVITFFILIFQRTSMKQKKMREIASRDGLTQLYNKAGTEQRIKEWLHSDRSKAGAV
LMMMDVDYFKQINDTYGHAVGDRVLYKVGHLLKSSFRENDIVGRIGGDEFLIFMEGITSE
EFAVRRMENLQQYLRELPIEELEEHTLTCSMGAAFMPKDGTTFGELYKHADEALYTTKRN
GRDGFRIYHEVEEKEV
>A0A897UES4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVTKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFAFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSPLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A031JW19|diguanylate cyclase|EC 2.7.7.65|Novosphingobium resinovorum|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A8B4U0N7|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATLG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHQPLANKEQVSGLVS
KWLFPEPTVQPIWHQGKQIGELQLTALDKLISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWLRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVGHQTSALLFLDGDNFKLINDNWGHAA
GDQVLTEVASRLMAFAGKRHLAWRLGGDEFAVLLREVHSEAEVQTLCQMLSQQFLPPFNL
HNGHTATLSLSVGYALAWEHATAESLQELADKNMYRMKNQRIQQTLK
>A0A379S2Q7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLITMTLIWLLICVASVLTLKQYAQKNLGLTAATIAH
SLEAALVFSDNAAAAETLAIPGRQGQFSAAEARDKNGRIIASWRYDAQAADDKLIGLISH
WLFPLPVSQPIWHNGRTIGEVRLVVRDSLISHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDQRIEEFHLFAQDFNSLLDEMEEWQLRLKAKN
AQLLRPLCTIR
>A0A2H1PPQ2|diguanylate cyclase|EC 2.7.7.65|Xanthomonas campestris pv. phaseoli|TrEMBL
MVLIDLDHFKQVNDEHGHLVGDAVLAKVGARLTACLRDSDKVGRYGGEELLLLLPGMSQQ
SQHRLRAIHEALSLAPYEVGTARPLQVTCSVGVSWFRVGDTAASLLARADEALYRAKRSG
RNRIEPEEPESSVA
>A0A379SUH6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLITMTLIWLLICVASVLTLKQYAQKNLGLTAATIAH
SLEAALVFSDNAAAAETLAIPGRQGQFSAAEARDKNGRIIASWRYDATSRRR
>A0A6P1USJ8|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MDKLMWVKKLRQILSPGYVVNLCFFIVFCFSTLLIWREIKVLEEAYVANQRNNLENVSHE
FDSLLQFNIDRMIFFRNGMQSALGTPLDFVVLRKAEEDYLKKRHDPLWSVEIHNRRTLPV
YGVADAFVDGDALLSRDNSFSGNELMATLELGYMLRLANNNRGFAKRMLYVSRNGFFTTT
EPLKNATQALALYSRATSAPWFTRQTQRNNPARGIVWQTFPDEASQREMQVVTASIPLDF
QRYWLGVLAMDFSVQEMKTFLVNAIKTGEEGEYQLYDNQLNLIASSAPGNVLTLLSPREQ
EMLSRASSHENQGGIRLVTRYISWENLRNFDGVLIRIHTIREGVRGDFGSITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFERATAEARLSERLK
RPVAVIQLDLDYFKSVNDRYGHHAGDRVLSLVASTIASHIRQGDLAGRVGGEEFCIVLPN
TALKEAKAIAERIRLRINSREILLGNSTSLRITASFGVSCSEDSGEYNFENLQSVADHRL
YLAKQNGRDRVCAEG
>A0A162SP81|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MVKRYQFEEIRLYAILSFIFMSLIYSGISFFYIPIHNYEYSQFPFVFKNFVFFSTWNLIR
YYHFNTVKYKNNWVFLIYGCIDLFTVSFYFGIPTLDQGGKIVILFLLIIASIYRGRKIGL
TLTLLWFPMKMASDFIFMRLLRDLGRPDFPKIMISENIIDALYFQIMLVILVFITEVIYR
QISDKEKENKRLLDEIEYQYKELNAAHDEIEGKNNKLKDANSNLEALNSKLVHRIAELFT
LQQVSKAIGSLLNIHELMNYVNDITLGVMGVKDSTIILFNEKTSELEVHTTNITDKEAYA
TLCNNINCPELLSILEGETAILDNNIDSNRFCFTVGRDIKSLICVPIVSKSKKFGLILIE
QNFENAFDIDNLKLLTVIAQQVGIAMENVDLYHKMHELAVRDNLTGAYNRLYFHERLQEE
LVNAKNECYELSVAMFDIDHFKKFNDTYGHLFGDKVLKTVTEVMDQSIRSKDVIARFGGE
EFIILFPYTSLAKAYKIVERLREKIASTNITDGSVCVSVTASFGIASFPQNASNAMELLK
KADDALYKAKDSGRNCVRTSDEYNHLNEEL
>A0A5Y3B5L3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKELSLPRPTFKRTLRQISIISVLLTMTLIWLLICIASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNVAAADTLATLGRQGQFSAAEVRDKNGRIIASWRYDARATDDRLTGLISH
WLFPLPVSQPVWHNGRVIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALVLTRYLH
NGIVDALQNITDVVHDVRTNRNFSRRVPDERIEEFHRFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSGINALMNNDAARRSSALLFLDGDNFKYINDTWGHATG
DRVLIEVAKRLTEFGGHRYQTYRLGGDEFAMVLCHVHSEYEVQRICAALSQVFHRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRTKRSLN
>A0A292YE61|diguanylate cyclase|EC 2.7.7.65|Lebetimonas natsushimae|TrEMBL
MLNKVEKELVKKMFFYPVFIVVISFILVVFSSYYTLYTFKSKEVDKNTKILINNKKNYLK
ENVINLSKDIDNALQFSLEETKKNVKHRVYLIYYAIKSLYSLNKNKTFIINYLNTLNTYL
KNHYIFAYDTNGIVKTHILKSFIGKNTKKIYLINHMSVFERNKKILNKNNEGFIKKYFYK
PNNKNKKFLKIDFIKYIPELNLIIGSGEYVDEIKNKLEKQIFQRIMMKRYGNDYYFFIIK
KDGTLILNPTYKSAIGKNILNLKDINGKYFIKEMIKKALENKNGSFVVYKWINPKTGKIE
KKISYVLFNKSIDAIIGSGLYIQEDIAKNINDIKKNLNEEFKIFYRNLVIIFLIILIFSV
FLSFILFRKLKNVFFIYDKLLKEEKKKIEYESLHDPLTKIANRRFFNQKIKEEILRAKRY
NHTFSIAMVDIDYFKKINDTYGHDIGDLVLKKMASFIKRHIRSTDIFARWGGEEFMLIFP
YTDLQKAKQICEKLKKELQENEFVQRPVKFTISCGITEFRKDNNIESIIKRADEALYEAK
NGGRDRIVLK
>A0A379F8R8|diguanylate cyclase|EC 2.7.7.65|Proteus vulgaris|TrEMBL
MNEMIFNDDNSKCLLIKQFTNNVFMMLVTDINGVIVYANEKYCEFNNVHFENIKDKKYNL
FYLIDENQINYCVNGNNDNKGVYRLEAKRNNESQQDVWEDISIIPVFDKDNLISHYVFIS
LDITDKVELRNELFSKSYIDSLTGISNRLSIVEKIENERLNISHPSSFCLGIIDCDKFKA
INDQFGHHAGDKVLCEISKRLSQLENSEVYCGRLGGDEFAVLFPNGLRSCSVILLEIIES
LWKSMEKPININSDYMLTPSISLGIAEYPKDGKTLSELLKSADETLYSIKEMGGNKYGFY
SGF
>A0A5Y2S063|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRLGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDSRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRIHDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1Z5I7K0|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MQTLNVLDNRFSPFNTYSSLGTDALVAENITDTVYDKRKVLDFMTQLQTTLDIDTLLNIF
AVEAARYVDFSGLYFKSQSFNKALRGSRKAKKERRFDLKIADDFIGTLSYGINSPISLTN
YKVLQQLHLCLLHPLKNAIAYHAAMQLAMQDALTGLGNRRYFDEQLKRAMHNANRHHSLV
GLVLSDLNKFKAINDCYGHATGDLALREFANVLRQCIRDSDSLFRFGGDEFAIIVENAND
SALAIIENRINLALASNVLLSKYQLSCSLGSTFMNRADNEMSFFERADKVLYQSKMKTTA
HLSVV
>A0A8A8DCE8|diguanylate cyclase|EC 2.7.7.65|Burkholderia seminalis|TrEMBL
MFITETGDAPAAARDPADKQPALAALPELVAVCRIARAHARAAGAFVARAGRGTQRVLAA
DGAVPDPLPADCFPAHVERDPSAGRRYVIHDLRCDDGPPHAPHIVAACELTAADGTTLGT
LCISNDTPLTLDGTPCALLLDLAVVAERALARALTETALRERLARVEEHSTLTALALTES
GTGVWDRNVETGEIHYSPAWKAMLGYAPHELSNRIEDAYERLHPDDADDVKAAMLAHFES
RTDSYEVEHRIRCKDGTYKWIRSRGKVIARDGNGRALRMVGTTTDITALRELAERLLDSA
ALVTDLTDQVPGLVFQLRQTAGGRRFFSYASAGVRDIYELTSEQLARQADTVETRIHPAD
LAAYRQSLQESSVHLTPWRLEYRVLLPGQGLRWREGDARPQRTIDGGTVWHGFITDATDR
KHIEAELHRMATTDHLTQLSNRHAFMRQSEAALRGVRATGHAAAVLMLDLDHFKALNDRW
GHPLGDRALRHFARLLLAETGPDCIVGRVGGEEFAIVLPGSDLETALAFARRVQQRARQT
QLTHEDEQIVLTVSIGIDAMRESDLGAYQALSRADKALYLAKERGRNRIEVYRA
>A0A259U5E4|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MIRKSVSVLLICDAKQHDEIKTTLDDARIDSCFNLHWSGSLSEGLGVLNNSTIDVVLLVL
ALLDNHGTSGLTQIRDCNPDVPVVVMVESSDAAVITKAVQNGGQDVLVKQEVTGNALARS
LLFAIERQRIVKKLQTASLVDELTGLYNRRGFMNLASHYVQVSGRSRKGMLLFYADLDNL
KFINDNFGHQAGDQAIVTTALMLKSIFRSSDIIARIGGDEFVVLVVDTNLAFAPEILGRL
REKEKDSIQPDPLSLSIGFAYYDPEKPCTIQELLVKADRYMYENKRTKRNEMQENTILDV
N
>A0A554WUT3|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MHRQPLLPASPTSETAGGAWPWPAPPEVLLALAADWVWTMDAQFRLARMARIDGQPLPSG
LEQALGVAPWDSPLFEPGHGHWRRHRRVLWSHRPFAGLELGWHRPGQPLRWFAISGMPRF
DDHGRFAGYVGVAVDITARKRTEQTLREVRADLTATLRALPDLMFEVDREGTFHHVHAPR
PELLLVPPQAIVGRNQRDLLPPQALRVAEQALAQAERDGHAHGYRYALQLPDGWRWFELS
VARKDTAATRTPRFVVLVRDITELKRREAELSELAFYDTLTGLPNRRLLLDRIEQALLRQ
AREPSWCALLFIDLDDFKAINDRHGHGVGDQVLAVVAQRLRAGLRETDPLGRLAGDEFVA
LLPDLGEDAATARRVAQRVARTLVRMLRMPLHERPGVVPSASVGVLMFRGHHPLPALLAQ
ADTLMYRAKDAGKGRLTLRWFGRDAPSPCPPAP
>A0A543Q3Q9|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MSRDAPDPRPKNGPWRRVWARLGLGGGLPAGASAAAHTRLEQYLAFSKAVGQVMEHTDQE
SILLESLCTLAVECTPVTLAWVCRVEPDNSLQSLADAGDTAYLDSFAERRSGLPADHGPL
FRVWQEQQPLFNEPFSEGPLRKAWRQNTRPYQLRSMAVLPIHRDHQPWALLVLYDRDQRG
FPQDCQVVLEGIARRVSEALEDWIGILRERVAREHQLLLGTALQAAEEGVVLTDADRRIL
YVNASFSRMTGYTLAEISRFGLHHLQGPRTDPRTLTEIDEALCGQGFFNGRLLNYRRDGQ
TFWNHLSIIPIYQRTGAISHYVGIQRDVTAEWLAREQLEYEACHDRLTGLGNRRALMDQV
AVTLPRVQRGHGALAICMIDLDHFKPINDLYGHEAGDHVLRVVGRRLHAALRRSDYVARL
GGDEFVLLIEGFNNFEELEMILVKIEVVINEPIHLKSGVVVGVRLSMGVCLSNSVYADDF
ETLLRYADQALYRAKANKRQRTRYWELCTMEENPSSADQMSQGLFETQMKWNISNEDE
>A0A7W0HIK7|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus kamchatkensis|TrEMBL
MFKQFIANSGILIAGFYLISKFFPSNIHKKSPVHMRLLAGAFCGLLSIVLMFFSIPLGHG
VISDLRHVPLVVVSYYGGMPSALAAGIIMGTGRFLFGNPFASIVSFFTSLAIAIGCGWIS
QRVKRHITITTFWMNVYSMCLISLALFINIPDKHIYTQTLVIFWPISIVATYVAANICKD
IRQSKDMLQHYKQWATTDFLTGLYNVRQFHTLFGQHLERAKQKNSCLSLILFDIDRFKLI
NDTYGHDGGDVILRDLGELIRSLVSKNGMAFRNGGEEFSILLSSCEHEAVTFAEHIRTTI
ERHPFFVQQQTVHITVSIGISVFPTLATNESELFKQADIALYEAKQQGRNRTIVYKKEYL
HET
>A0A554WIV6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MAPACDPPSRRRGSGWLALARWLWLLLLLGTWGGPAHALVAGRTPGAVEVAVPVGEPLWL
RPYARTLRETQAMASTLGPALLTQDLPWEPVTSLEPVFAFGFDRSAHWVHVALRHDGPEP
ARLVLEAAEPLIDDLRLWVVDRASGALVAHAQLGDRVAEAVRPLDYRHPALPFVLLPGHT
VDVLVRVHAVDGEHDPLPLRLWNASDFFDHALWDNWIYGAYYGALSALLLYNLLVFAGTR
ERTFGLYTLFLASFLLWNLTYRGYALQYLWPGAVTWNQIALVSFSALIYAGMAAFSWSLL
EVPRRAPWLFRLQAVLALAALAHAVWIVADPTAATFATLDLVGLAMFVVLLLAAARIAWR
GERVAWIYLGAHGALFAGAGVYYATKLELITPGPLSLHALNLGSAAEFVLLGFALAYRIN
RLKAERDHAQAELVRTLQDAAQRLEREVAARTEALRQANHRLEELATRDALTGLLNRHQL
HERLVEELARAQRSGQPLAVLMLDLDHFKALNDRGGHPYGDHVLRQVGALLAPPLLRATD
RAFRVGGEEFLVLAPGTDAAGLQRLAERIRGAVSQQAWPHPDAATGWVSISVGGTLSQPQ
DTPESIFERADRALYEAKHQGRNRCAYA
>A0A839BVI9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00318|TrEMBL
MQRETFVVRRSFLQWLHMRSNPGLIVNLCFLIVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRKSMRDAIQTPLAFDVLYEAISRFNAFRTRPSWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDPERISNEISAALEVGYLLRLASSVGQSEERVIYASRA
GFYLATDAPEQTSDISQRYYYLVTQPWFTQQSERNNRARAVRWFISSPSPWTGGERMITA
SVPIYFDHYWYGVVAMDFSLKTMKHLLEEATQERTEGEYQLYDTRLNMIATSEEAGSLVN
RFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKMLS
EKCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIGSALRKNDVAGRVGGEE
FCVVLPGSGLEEARGIAERIRSRINSKEILVKKSTTVRISASLGVSSAQEKDNYDFEQLQ
SVADARLYQAKQCGRNRVFWHDQDKK
>A0A8J7V5K8|diguanylate cyclase|EC 2.7.7.65|Candidatus Obscuribacter sp|TrEMBL
MAYRQGGWHVHQAQGIRLVTVMVHTKDIGDERRKEQPAGNPQLSLESTGKPEKTQPTSDK
LTVAATEDSSSKVTARSLATELAKVSPDSDLIIEHLRGKTGQELKNIAALYKDQTRHSLS
GDLEKNFTGSDRIKVSQALQGNFDDTTRVRANLVALTELSGKSNQNIEKDLRDTFATLNK
EQIDTIARQYQERFKRPMTTDLERRWLLSPESKQALEIYLKGSENRTSADTQTLATIAIN
SKNIDMMREAFREASPEARQTFLSKQGEQKIREAFNARETDIALDYVKLGRLDITTAIKH
NSSFAGDNEQAIYFAASNMTAQQKANYSDGRRNEQKPMSALSSTERQQVEFYRKLSAAFK
DPLSEREMLICEDKIVSPGGRSTVSKIAELGGAIGANGREVNALLKAMPKAELERLRSEP
QFRKDMDSALKLSGMNYRERFVAVHMLDEIVTGKYKPAPKGDETAQDANLRLAERISKYT
HISGDDKAGFINSLKNAEASRLAAQDLAKNPRAMDNLLNPSERQLARTIIEQGGKSEKAD
ELRASILAVSKDKASIASVLEGMTPEQRYQARGVYEHKYQSSLINDINENTRGRERLTTL
DLMRTPYTMREDYNNRRDSVYNSVDGLGRAWVERLWDGTSDQTHDVLEQYAAANTRYSRD
FMLMQPEERKHLSENLNKALNLYKDSKNQAADATVAAALTGTGLAGAAFTGGASLTLLAT
AGAVVSVGTKAAIEGADYNKGSIVADGLTGAVSAGTMGFGGRQLAEMLKLGQQAAVASAD
AVVKGSETIAKETGVALVRPGAKAELEQALAGQIRDSIASGADTVSAAKLDKLARKFATS
EGNASALNVMLTMELNKALNETGTSAVKRVVKGVALGSAAGGVGGVGAGTVHGIDEWSDK
KSVKANMAHVVKTAATTGAEYMTLAALGQSATSCLRQGAREGVKKLESTERLTEAKNIAA
LASDAGKLEASTTLDPITNLLNKTGSEQALVRTVKQIERAEAKGGSRDLTLMMIDLDNFK
AVNDNLGHDRGDEVLKVMGKYLKDRMRASDKVGRLGGDEYLAVLPDTKDTAKLVKDIQSL
RLEASASGVRILPAGVAPSPGSYVVKASAGATTRRAGEGASDLLARADHEMYLDKAARKG
KVVDTTAKPSETAALSEELRREAVMHRVVSGRREEELLNLNAGRLREISEGLKRDVTTMQ
ERENIDPLTGLLNGKTIRTNLETLVAQSERALAKGEERHLTVVYIDMDGLKGVNDKLGHQ
NGDQSLRFMGQKLKELARDTDYVSHISGDEYMMLLPDTNGAQAIAQRLDKLRFAMQANGE
TRPLAAGEALKEGEVKIGFSAGIVVKQPGETAEMVRQRADALMHENKMYKKTHQVFYASE
IPAQLEIQKQMREQGHIMEADKLLNDIQFAREHQYLAGKRVREEREGLTILP
>A0A5K1JCF2|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNTSVAMKASRAVRLLMMVLTAVLIFFFINVMLLVSDIQGTARVVNYAGLVRGTTQRIVK
LEDAGQPRDDLLRAVDSYINGLRYGSDDLNLVRLDDDEYQAKMTELANYYDELCAEIIRV
REVGYENTDIIAMSEEFFGICDDATRLAEDYSQEKASALNYLEGLVIIDIVGLVATFAVE
LVRAVRTAALNRELQNKVYLDEATGLPNKNKCEEILGQEHPVSAEAPVALCVFDLNNLHT
VNNSFGHEKGDEYIRSFAQQLGRVASETCFVGRDGGDEFIAVLWDVDRAAVESFLARVRA
NVNEHSEAHPDMHISYAVGYALSSDFDEPPTMRELFSQADKNMYIDKNRAKTAEAAGPQR
EER
>A0A0C6P5K8|diguanylate cyclase|EC 2.7.7.65|Bordetella bronchiseptica 253|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A380T321|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MLLSIPTLLLVAIFIFALMGLLTLHAWSRGVRERTLGYLGSMLLLAACGVTLISLRGLTP
DFIALVLGNIVLLLGAALNWTAMRVFTGRPPHLPGILAGALFWSLWGLMPGFYDDLGLRV
TVYSMLAATYGGLSIFELWRSRQQLEVSYLPALLLMLVHTGFYCVRTVADHGVSLDQAIT
SNGRGTGFFSFMLFESMLYAIGIAYVTLAMVRERTELKFKAAAYADPLTGVGNRRAFMSR
GEKLLADCARRGEPVALLLCDLDHFKRLNDTHGHQTGDQALIAFAQITRNSVRQEDVFAR
IGGEEFACLLANTDAQTAQQVAQRICESFYALPMLEPGFLSVSIGIVGASGPGEHDLSRL
LSKADNALYAAKHQGRNRVHLYQPARWLQSEQPAGTL
>A0A6N2WUF4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MENTQKKSSGKISYTLQIIGLLPLLALGIAMLFFTSQWFTKTMYQEVERELYDATKSATT
LLNAAYPGDYHLEGDVAYLLYKGETDITRDYSLLDQFKEDTGLDITLFYQDTRILTTLYN
AQGERIVGSGAPDIVIRDVLNTGENHFYTHTLINGKAYFSYYIPLRNQDGSVVGMLFVGR
PSETVSLSIQNYVYPLTWLIIGFVALVSVCIYFYTRRFVAVLLHIHSFLSEVASGNLNAT
LDHSVTKRSDELGDIGRCALSMQRSLRTMIEQDALTELYNRRSGDKKLRQIFEEARSSRH
SFALAIGDIDFFKKVNDTYGHECGDAVLKNVSALLKQHMWRRGFAARWGGEEFLLVFENV
DLTEARKQLELLMDKIHELDTLYEGQHVKVNMTFGLVCESDKDIHALLKEADEKLYIGKT
NGRNQVVS
>A0A1C6KHD1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MVITGNFSSDIPKNKMLMMRTDNLKVKIFVNNNKVFSFGEEGTYTEFSKSPGNCWNSFVS
PGISKEDSIRVELYNVYTDHVEFTFDSFLDNLYVGYESILIVDNIRVNFLNYLISIFLIC
LGVIVSILSYILFKMKRSMLKLICFSGLSISTGIWGFIDFNLQGYFTPYLVFNNSIDILA
LLFMIFFSLSYYALFLTGIRKNILLGLAQVILIFITYSTIMQVVGSNDYYDYLKFIQIIC
GIFSIIILICTVYEARVFKEKEIIKLSIYSVILLIGVLADTICNLTEIMPYAIWFRLSFV
IFLSIQFIRILRDIKNIIIKNAKLEVLREMAYKDALTGINNRRAYLEKVEMLKSNLSRTS
RVSIIVLDVNNLKKVNDTLGHEAGDKLIIDSCNIISNVFNKNDVYRIGGDEIVVILENIH
EYKVDKLIDKFIYEIEEFNLLNNRKVSIAYGMSSYDNENENDKSFEEVFSRADDEMYKNK
VKLKKKL
>A0A1C5WFS8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MESKKRQILQWSILGGILVIVVTVMLCVSFSRIKREGIQNYEDVMTSSASKYAQKVNMEL
SELQTAADVAADVLSTSSHYGQNLIKETLMAVQENTSAEKAVYYNGGNTGYVWDGTDFAT
ADLKKEPYFEQLAGLSETKVFCMRNSEDLKTTELVIMAPSGETGKGSVLLYLPVRKLDKL
FKISVDFGADAFALIIDKNGYIVTSGTYESDFLTELNFWNNFADKNKESVSKARVRLINA
VTGCIEASSKGTGEKRTVVYAPVLNSGFDVIIGVDQSYVDKKESNFWKSSGVMLTQLLLV
LIGFFAAFLTISYTTKKNVAEHDRLLREEADTDLLTGLTNKLATERKIKEYMKENPNSLG
MMFVLDIDNFKKINDTMGHAFGDEVLKTLGRTISSLFRVTDIIGRTGGDEFTIFLKFLKS
DENTLKEARKLVQFFKDFTAGEYVKYSATASIGAAVFPENGSDFDSLYKAADKALYKAKQ
RGKNQLAFYDDRDRK
>A0A6N2ZEC8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLAAALRAGAFVFAAYATGRVLSRRARAGDERRIEQLRRECGTDMLTGLLNRRGGQEKAE
TMLAMCRRCEKPMAVLMADIDHFKEYNDAHGHLAGDGALCRVGGALQSVLARSSDMVCRF
GGEEFLLCTPCRDTAEAMRQAARLRRAVEELGPCAPDGCCAGPLTVSVGVTVYSPARDGS
APVLQDLVSRADRALYIAKKNGRNCVVLL
>A0A1C6DQS0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGNELLIALAKYLLFHTNPNDIVIRMGGDEFVVFLKNVHDDLTYPCNQLMSHLNEISLSH
HGIHFSISMGVYTFSNEQNFDNIFKIADDALYHSKRNGRNRYTIKYQK
>A0A1C5U7X9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MPVDNYVIFYIPDVRYVSSVLVEKGAEVSGNSVKIANIFSCINIFIVVVNLFYPWMYYFD
EANYYHRNNFWYVYTLISLVVIFIGVGMAIKYRKYLKKRSFISMMLFSFIPIIATVVQSF
IYGFSITNLGLGIGLFVMFAAYMYEWSHNGDEYTNMINDSRFDAVIMFIIILLSMSVSII
ACVNEIQQVTKENSEIQSRTIAQMVSAKIENEFIKPITVSQTISSDIDIRTYIEGKTREE
AESVKDDITNRLVSIGNEFDYKMIFVVSDKTRAYYTYNGISKYLDVENDSHDIWYKDYLD
SGKRYTVNVDTDEDNNCSLSVFINYGIIDTNGDILGACGVGADMNDLVDILARFEEEYNI
KVYLVNHDGLIQVDTDVSSIETGYLDNSYFGNISDDDFYYQLSENGCYMTKYLEEFDWYI
VIRDNNPVKLDVNKIILPIVLIFIASVLIMATSFVIISMREKKAKDAYNRRYEASIKDEL
TGLYNRRGFEVDCEIIKKNNNLIEYVLIMMDLNGLKEANDNIGHEAGDELIIGASKCMDK
AFSGLGRTYRVGGDEFVALLRGTREEAQDAVKTFDYLTENFQGNLISEISVSKGVVVCSE
HIELNFEEIKAMADKLMYADKDEYYRRTGKDRRRV
>A0A6N2SD86|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MVPNYYNIIHMNTNTNNHKTSYSIIRGLFFLIMCSVIFTVLYYSLPRQNREPAISDYIDF
SEGWTTSDGSPVDFSHISGTCTVTKKLPALTHDMALFFFYKSSNVTILIDDRQIYEAIRP
EGVFFGKTPGASYVSLPIYREDSGRTLTLVIDNPYGDGSGKINHMYLGRSEDILISRIRD
KAPGFGISFLIAHLGLAFILFYLPLHKKHIIGSEMLYLGLFALNTGIFMLADNRMLQLIL
RNSHIYHTIAELFMMLITIPLFLYLGKMYTEYSPVMVQAACLISVMDFSIRFCLNLTGLK
DFHESLRLTHITFGILIALVIYAIGKGFYQNQRQHLKHNLYHNLGILCLCFGVLLDILLL
WFGSAPETSFFTRIGVLMFLIMEAVQVTLRLMTNYQEGVRMQLLSRLAYRDGLTDLLNRT
SYMEELKKLDASHNFHVLLALYDVNSLKYVNDTYGHQSGDEMIRRVADTLSAHLGSLGKC
YRIGGDEFVFLSTVSDSEKEFLKLQRDFEASLGTLKLPDGSEHPITVAMGYSVLTHNMPR
SMDDMVREADAKMYEAKRRMKTEN
>A0A1C5NX08|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSDPLESAIAGETRVILAVPIYNQQKEIIGVLGGSYDIGNLNKIVFKNIYGGKGSTFIVS
KDGRLITYDTAFKNKKILQAESIYSYFAGYDVLSTDKLQSLREKFTKQKKGYITLNYQNK
KSYMAYYPLKINDWIMCYSIDADVAQESYTVIISLGYLLFTLFVLGLLVLLYTIFNINKK
HQKNLLEYVRKDALTGIKNKETLKTEITNYLAKDKSQHTGALFMIDVDNFKMVNDLNGHV
IGDEVLKAFGTLLKESFAVDDIVGRAGGDEFIVFVKEIEDEIQAQKKANEVCQKIREIYI
EDFKGSISCSIGIAFYPKHGITFKTLYNLADQALYQTKNQGRNGYTCYIEK
>A0A1C6HN04|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MMDIDNFKKINDVYGHIIGDKVLVESASLIRNLIGPEDIVGRYGGEEFIIILKNRNNNFK
DTLERIRRGIEQLSIEINNDEYINITVSIGVAKFDVKNMTLEENIALADKSLYKAKNLGK
NIVVYW
>A0A7X0IM43|diguanylate cyclase|EC 2.7.7.65|Rhizobium lusitanum|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGLKALAICAGTQVDLVLLDIMMPGMD
GFEVCERLKSDPRTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELHMRNETARNFGIDDLLRAGDGRADDVGHVLLVDGRANSQERIIRALKPIAQ
VTAMSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
DMIVRALDLGVNDYIVRPIDPNELVARCLTQIRRKRYNDRLRASVQHTIELAVTDALTGL
NNRRYLDNHLKILFDRSLARARPLSVLIADIDRFKQVNDTYGHDAGDEVLKEFAARIRST
VRGADLACRFGGEEFVVVMPDTPADIAAVVAERLRAAVENMPVRLRDTGVALNITASFGI
SSRLTTVETPEQLMKQADLALYEAKRAGRNRVVASAA
>A0A446CVA8|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MTTSLFFLMWGLATGLALPLFVPFHASNVGGIRAFTAANALAVLSLLAYASSRILPPGVY
VIVSNAAWVCALSLVYVGVRLFFGLRPQVLRTAGLGALCILAFALLLYGGDDLRGRILLF
SVYTCTGALATGRVIFQQRKRLKTRGVMLYLMLAIFGLAGLHALRVAVYTIGGQMPVSLL
DPSPWALFFIVCGVVTVPALFLALLLLVQTSQSEQMQAALTFDSLTRAYSRRSILDELGR
ELRRCKRVGGKLAVLVLDIDHFKSINDRYGHAGGDTALRHYAQVVQRAVRSSDRFGRLGG
EEFVLLMYDCDSARALVQAQRVCDVLRDAPLYLQGAEVPMTTSGGLAVYLPGDTADGILA
RADAALYRAKQQGRDRVEMAWPGRAPGRPADAAPAAHEGAESTV
>A0A403M3C4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAA
ALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFL
QSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNN
LRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSID
ILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQ
RLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGG
DEFYIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDER
LYVNKQNKNSRS
>A0A3P6KWU0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDE
FAMVLYDVQSESEVQQICSALTQIFNLPFHLHNGHQTTMTLSIGYAMTIEHASAEKLQEL
ADHNMYQAKHQRAEKLVR
>A0A3R0JRA9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSIYRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A2S8DA42|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
EIHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A3R0WV56|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENHHRAVRWFTSQPEHASNTEPQVTV
RVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEVAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7Z7HT31|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MSAAPTAVPYPVASAGRRLIAIALLAAIYAAVGVGSFRLFHSAGILPIIWVPDGIVLAAM
LLMGGWLWPGVFLGSLATMLISGFPVFEALGLAAISAFNVLFCHAALRHVWKIDIGLGAL
RDFFALVWTAAISALLSALLGSTVLYLSGSLNGAVFGLNFAHWWQGVVLGLVLVTPLILT
FRNPLESPLSLRWKIECALCLLLAVVFGQVILVGWRFEPLMLVVSDNWMFLFATWAAASC
GRRAVMLIVTVFAVQGLIGAFSGQGFYAADLEKTGLMQYWFLVILSCCIGAALSILLFER
RQKSAEIAYALQYSEDVLRSLPGIFYLIDMQGRLLRWNPAYADIVGYTNQELVGISVLEL
IAEEDRALVAARMADVFTHGEAQVDAGLLIKSGQVIPYHFTGRRTMLEGQPCLIGLGQDI
SERVRIRQAIEDSEARYRLLFERNLANTLIIDPAGIILMINENNARVLGGTVEDFVGKSL
YTLMPAERAEIYRQRFAEILATNDDRAYEDAFDLPEGEHWFASRLSPAIDAHGQVYGIQL
VAFDITERKRAESALRESELKYRQLIENATTFVTIFDGDGIIKMMNQANARMFGVEPEEL
IGKSLHELDPEHAEQFIERYRSIMASGESMTTEDPFPLPDGLHWFRAHLSPMFDSHGQAV
AVQVVAFDITERRNTEDALRRSEALWKFALEGAGDAVWELDIPGWHSTFSPRWQQMLGYG
PDEVVDNLHDWMSRVHPEDQHDVANTLEAMLSSRISTTSNEVRVLCKDGSWKWVLMRSMV
TDRDAGGRPLRLVGTCADISIIKEHQYQLEHLAHFDMLTDLPNRVLLGRRLQQAMAQTLR
RGQSLAVAYLDLDGFKEVNDAHSHQVGDELLVMLAQRMQETLREGDTLARIGGDEFVAIL
TDLDEPQDCMPVLNRLLNASSQPVPVGRLLLSVSASIGVTLFPGDGGDADQLVRHADQAM
YQAKQSGKNRIHLFDVRHDSAIQAQHETISNIRHGLRQGEFVLYYQPKVNMKTGALIGVE
ALIRWLHPERGLIPPIEFLPIIENQEVSLELGEWVIDRALIQIGQWQEAGLAVPVSVNIS
AHQLQQGNFSDRLGELLARHPLVDHTLLELEILETGAIDDLPQVIRFMKSCQALGIRFSI
DDFGTGYSSLSYLKRLPEAVLKIDQSFIRDMLEDPDDLAIAEGVIGLARVFRREIIAEGV
ETVAHGELLLQLGCHLAQGYGIARPMPADDLPHWAASWQPDDRWLAWSEIPYPNPDTSLV
LAEVRHRRWLRSIGHQIEGIVQDDGALLHQPGPLAVWLQERGAKYRGKFAEFEAIEALYE
QIQRLAQDAVAAHADGKEEKARMMVDRLHELNEKLISLLHTMALGYAR
>A0A3P6L3W7|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSTMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGISPV
>A0A7Z7HNM4|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MTTLGIVPGPLITAYHFSAGFAAFAALVCAAVALSGIRIRGIWWLAAMCVASVGSQLANA
DFHVAPNLLAATDAQRWQNAWSAGQLYTLTGFLAIYTRHRHRRGFLIIMGVLFASMIAMA
FQMPPGGRFAGEYKSVILEFPWGERLQMLHGELSRSSLIGRTGFFGLFLWGLYRVAIPYA
REDRTGSIVISLGLVILILATALGGLVETGTIAFVYFGNYGYIFLVLLVLYLVVRKLLAS
NARLKRMTAALHNELDSHLETRKVVHHLSFNDRLTDLPSRAGLFNLIRKPIEQAQRQHSQ
FAMLHIDLDRFDVINDTLGPNVGDRLLQEVSRRLQSRIQGEDFAARMSADEFIVVINGQP
AAAAAIGFADTLHELLREPFAIDEHTLHVTASIGIALYPDDADNAEALLVAADLATREAK
RQGRNCTRFFRRELDDAIRERLHVGNALRMALAEQQFELYFQPQIDARDGHITSLEALIR
WHHPEGGLIEPGRFIPVAEEMHLIGEVGAWVIDEACRILADWREAGIHDIRVAINLSAQQ
LHQTELIDTVRGALDRHGLTGNDLELEITESMVMEDPDLCIEQLRQLSALGIKLAMDDFG
TGYSSLSYLRRLPIDTLKIDRSFVHDIETNDNDATICATTISMANTLGLDTVAEGIETEA
QANRLRDLKCDRFQGYLFARPMPAPAVSGFLRNYSIGT
>A0A0H4W4A2|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MDDGSLSLWTARRRMTLKQALLLLGTVCAMPACLIAAAVAYEDYALRARQVYQSVVETAR
AIGSGLEHEQNGVQAGLRMLAAADELRGGDLRGLGGRMLQIMRLQGVDGFVLADGQGRVL
LSEGDTQCPARIPDTLLAGALREDGLVVSGVLASAVPQRACILMGLPVRLAGRDGHGLYA
QIGSGRLSQALQRYPLGEGWVTAVLDKDGRIVARSRDDRRFVGGLAVPALVQATRERAEG
TLETLTLEGVPALTAFTHTSAGTVAVGAPAAVLRAGLYRSMSLGLLAGLVVLAAALAVAY
ILARAITRSVRGLIAPAEALGRGAPVSVAGTAFRETEELGAALVRASRTLARTREQAYHD
PLTGLSNRLLFRELAQLTLRAAEREKRPVALLMLDLDGFKGVNDRHGHAAGDRVLTQAGK
RMVDTVRGSDVVARLGGDEFAILLPGADAAAAARVATLLIAVLSYPFPDVSPPVSASVGI
ARYPQDGTALEVLLERADRALYEAKQAGRSCYRGTAQKQDEPGVLPG
>A0A378GN09|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MKLQNKILRFVISSGVVILTSSFLIYELVASHRDMSEYMRYIIDKGESAFLYEKYQNQLI
ISQFAQKLDERPTAEAAAHACASVQHRGNIHGLNIDGYRYSKLSGSLTAGKTPCDKWAQS
LPALEAFDAAVDNSTAWKPRLPDAIPQQKRFRYYIDVVNQYIYFNSPVVIHDATLTSWNF
LYGDRLGISPASLENLFLGRTVVSSIYIDTFTHKNILTFLTPLYHHENLQGIVMVDLSHQ
DLHDIFYTRDRPHFWRYLDISFIDSDNNAHIEVHRSTSHLLSYVHYSRPLAENMRVELSL
DVMYFLLSSWKLFLFYLISTTALLQLVRTHFRLYRTVSQENISDALTGLYNRKILSSVQS
MRLQRLTEQGVGVVVIALDCDRLKFINDTWGHDEGDRAIIMLAQAISATIRKSDYGVRLG
GDEFCIILIDYEEAEAKVITERIQDHLALIDTESRVSFSWGAYKMRLGDSLEQSMKIADQ
RLYQHKQRNKTASAHAYGKNND
>A0A1V5IK55|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MGGYSRAVVSALDMDIGFKSILDALHDGVYVVGPDHTIVYWSEGAERITGYSPDEVVGRR
CDDAILAHTDLTGRSLCAAGCPVRHCMDTGRPHDVREVFLKRKDGRRLAVYVKTTVLEIE
GRRHGVEVFGELESVAGKELVARIQELSDSAVTDPLTGLFNRRYLDAVLAQQFAMYRRLG
RRYGIIQMDVDVLKEINDRLGHATGDEAIRFIAGVLADNVREMDVAARFGGDEFVVVCGV
GGRDHLEAYGRRLMRLVHDSCFVPAERAGLRLTVSAGGTLVTDADVDEREALRRADRAMY
AAKRSGRREFVVLDGDEPQR
>A0A5E6YWD0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSGLNAPQRRRRLRSVLRRGHLGVALVAVTLASASMTLLGVLALKVYADHNLHLIARSIN
YTVEAAVVFDDPGAATEALALIASTEAVAEAQVYTAEGELLAQWQRPQTDLLSRVEMLLA
DGLLQQPISMPILHQGQEVGRVVLRGHGANMLRFLLSGLLGVLVCTALSAWSALYLSRRL
LDGITGPLQQLAQVAHAARRERAFDRRVPPAHIAELDSLGNDFNALLDELESWQSHLQNE
NEALAHQASHDSLTNLPNRAYFEARLTRTLRSLNKTRDKAAVLFLDSDRFKGINDAYGHA
AGDAVLVAVATRIRAQLREDDVVARLGGDEFAILLTPLHKIEDAQRIAEKIIASMLEAIE
LPGQVSVVTSLSIGIAVYPEHGASAQELLCAADSAMYQAKRLARGGQHVAESEHPANTVN
IRS
>A0A448DZH1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKSPSQTNAIDFDSAKLQRLGFGRLPPLLERPTSLAQLRQQMSLQLQTSLEPQRILGLFF
REVQRLVPLDALSYVHKGSELRLEFGTRGHHSISYTLSHEGEHMGEVVFRRNQRFSDQEQ
GHLESLLSSLLYPMRNALLYREATQSALRDPLTGAGNRIAMEQTLQREIDMSRRHQQPLS
LLMLDIDHFKRVNDSHGHGAGDDVLKAMAATIKAQLRNVDMVFRYGGEEFLILLSNTNRD
AAAMVGERLRYATQAAEYYADGKLIELTVSLGCSTLLPGESADSLLRRADNALYVAKREG
RNRLTMAG
>A0A5E7LSK0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNGDGIMENKIGKGKSFAKRIYLPRLIGLAIGMLSVLAAIAPLGLPGWVWVLLLFNGLVW
PHLAYQLATRASEPYQAERRNLLYDSVMGGFWTATMQFNPLPAVTILSMMTMNNVAAGGQ
RLFVHGALAQVVGILLAITLFGPQVQLTATALQIYACLPMLTLYPLALGWVCYRLAIKLA
DHKRRLSALSCTDSLTGLLNHGAWKDLLHLQFFAFRQESFETVIAIIDVDHFKQINDTYG
HLVGDSVLRQLSAELKKNLRQGDLAGRFGGDEFCVILPNSPLSQAGEIMERLRGAMGNYR
NEQLPELRVSLSIGLASCCSAMTDAADWLNEADKALYAAKNSGRDKVHFTLGDIVNAP
>A0A5E6W2W9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MNLFRSNSRPTLGSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKSAANESLALIASTEEVADAQVLDSQGQLLAHWQRPENGLFSELEMQITR
AILEKPISLPIEHQDREIGRVLLTGHGGSLMRFLLSGLAGIVLCTAISAWVALYLARRQL
RAITGPLRSLANVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAGKHNERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKVEDAERIADKILASMDMPIAL
PGDTSVVTSLSIGIAVYPDHGATPGALLDAADVAMYQAKRLSRGAQFTAGAEHPVDSVQT
RS
>A0A5E7PTX9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLNPPLWVWALMFFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGSRFLLAG
SAAQLLGVGVGLVVFAPAFIPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFAILGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKASGRNRVICNCDGKPRRTLLDSV
>A0A379IFP9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAAGGKGLPLARRLYKSRSLGLALGFVCVLAGMYPLDPPGWVWAWMLINAFAWPHLAYQ
LSRRCENSLRTERRHLLVDSFCGGFWVGAMHFNPLPSVTTLSMMTMNNVAIGGPRFMLMG
WMAQALGIGVALLLFAPAYIALTTPVQLYACLPILTFYPLALGWICYRQAITLARHKREL
LALSRTDSLSGLLNHGAWKDHLEIEFARCRGGQQGAAIALIDIDHFKVINDTYGHVTGDI
VLRQLSKILRQNLRATDLAGRYGGDEFCVILPDMPLGRATEVMDALRDRFSSLGYAQDPT
LRASLSIGLAPYQPSHSDATSWLSDADQALYEAKSSGRNRVRSLQGWVRSV
>A0A564SIW9|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MDINGLKNANDSFGHAAGDELIRAAADCMKNSFSEHGKVYRMGGDEFVVIITKDIPQFEN
LLRAFEQRVESWHGEFVESMAVSYGYVFSSERKWNSIFDISKASDERMYESKKQYYTRSG
MDRRRQ
>A0A5E6ZI19|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRILGLALGLLCVGAAMYPLDPPPWVWVLMLLNGVLWPHVAYQ
WARRAKVPFHAEHRNILVDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQVLGGGIGWLIFRPLFIPQTTPLQMYACLPLLSLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQHQGGAVALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKQNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFVTLGYEQNPA
LKVSLSIGLAAINPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRQELLDPV
>A0A5E6WQ77|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MIDNRSGKGLSFVRRIYLPRILGMGIGLFSVMAAMAPLHPPGWIWALMLVNGLLWPHVAY
LWAKHSTAPYRAEQRNLLLDSLMGGFWVAAMHFNPLPTVTILSMMTMNNVAAGGKSLLAR
GLLGQLAGMLLASAMLGSGLQLQTSALQVWACLPLLALYPVALGWVCYRLAINLADHKRQ
LSALSRTDSLTGLLNHGSWKDLLLLKFQISRQQRLPAMIALIDIDHFKAINDTYGHVVGD
CVLRHLSQELQRSLGPDDQAGRYGGDEFCVIFPGADQARAGLAMEALRERVNAYRNPQLP
MLRISLSIGLAAYDELLKSPEHWLEHADKALYAAKHQGRDQVSFNHGPAAPLRLAYPD
>A0A5E6RCD4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLDPPLWVWALMFFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGSRFLLAG
SAAQLLGVGVGLVVFAPAFVPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFAILGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKAGGRNRVICNCDDKPRQTLLDSV
>A0A0D0SBW3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPANLKLRPRMRSLLSPAVTQAEWIGIIAWVGMLLIHPALQLDIYTVGVTLGLLVVCRVH
TRTANFLLWRVLGVTYMVLLSVGFAYIIRLNEELRIYGLPLAVTLVVGSAILFISVQDYL
ADALLVWLILWPPMQADIYAGTEVYLLMFCASSVSIGFILSYSYLKNLRSVLLVESEFRA
LAETDYLTSILNRRAFMQSFEKLLSGGQGGYFIMLDIDSFKEKNDLYGHDVGDKILRAMA
VCLKNAKGSHSFGRIGGEEFGVLLQGDDPELACDFALALLQSIRSSVAAPHNYTCSAGMA
RFSAGGDLSTVLKMADKNLYGAKRNGKDCVHLDGALLQPVLS
>A0A5E7BQI3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MENRQGKGLSFARRIYRPRIIGTAMCCISVIAALYPLAMPGWLWALLLINAFVWPHVAYQ
WATRSKYPYDAEQRNLLYDALFSGFWAATLQFTPLTTVTLLSMVAMNNVAAGGKRLLIRG
ALAQVLGAAIGAVVFGLHFNPSISLVEVYACLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRIDSLTGLLNHGSWKDLLHLKFHKCQQQQSHATIALIDIDHFKRINDTHGHIVGDA
VLRQLSLELRRNLRENDLAGRYGGDEFCVILPQMPLEQATQVMERMRETFSNYRNPQIPE
LRVSLSIGLAGFQPSFTNAAMWLNAADRALYAAKDTGRNRVSVSDDKVAYSA
>A0A1V6IR70|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin022|TrEMBL
MIEIDMRIIFAEYGLSVLLCLIVIVSLWWQNRKRAPEIILWLIDYILQFAGIMLIALRGI
LPDFMTIVVANLFIVGGTVILYEGLCRYVGQESRQKHNYVMLAIFTSVHIFFTYIAPHMG
LRTINFSVALFYICIQGAWLMLYRVASPLRQATKITGIVFAAFCIVNIIQIIINLIKTPS
DNAFVSGAAGVIAVLIYETLFFALTFSLFLLISRSLAIELENELTRRMRTAEELRQNQEK
FAKAFQTSPYAISITQMKDGKFLDINDAFVNITGYSREEIMKESSMGLNLWVDKEDREEM
VSILRQGLPVVRKEYRFRKKNGEILTGLYSSQIINITEEPCLLSSINDITEQKQAEWTLK
ERIKELNCLYGISAVLDEPGISLNDIMNKAVKLLPAAMRFPDITGARIILEETVFQTGLF
KETPWQLTEKITVNGKPEGQVNVCYPAERFQTDEKPFLDSERQLLKAVAEQLGHFIEQKR
AEEQIQRNATRLTGLLNIMQHRTQTTQEFLDYALDEVIRLTESKVGYIYLYNENSRQFVL
NSWSKDVMKECTIPNPQTRYELAKTGIWGEAVRQRKPIIVNDFPADHPLKKGYPEGHAPL
FKFLTVPVFDQDQIVAVVGIANKARDYDETDVLQLTLFMDAVWKSVDLKMGEAKLRKSEE
RFKQLAEVFPETIFEADAKGNLTYANEHGLKHFGLTEQDIAQGVNIFDFVSPNDRKAAWE
KIQNRIQGTQKGYLEYEALKKDGSPFHALALSVPIAVDGVPVGIRGFILDITKRKQAEEA
LRKSEENYHFIADHTADHIWTMDMFMRFTYSSPSVIKTLGYTADEFMARKIDEFFTPESL
VDAQKLLAEELERENDPTADPNRSRTLPSHLRHKNGHWVWLESSLTFIRDASMKPIGVLG
VTRDITERKKSEEQIKHLATHDLLTDLPSLRLARDRMVSAMNMARRYKKSAAIMFLDLDG
FKNVNDTLGHDAGDYVLKQVAQRLLSCVRETDTVARVGGDEFLIIATEIHHPDNAAHIAE
KVIQTVSQPIMINGEQAVVGTSIGIALYPEHSEEMDRLIKLADEAMYKVKNAGKNNFRFV
NDVN
>A0A5P9JRI7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MSDTTELTELHWLLAIVQSIDVGVVVLDRDFRVEVWNTFMENRSGLPPAKARNRSFFSLF
PEVDEDWFRRKVEGVMTLGTPSFTIWEQRPYLLRFKNYQPITGLEDFMYQNTTLLPLKGI
DGSIAQVCLIIYDVTDVAVNRRQLQAANAELQRLSSTDRLTGLYNRGHWEEMLQLDYARH
RRYESQAALVMFDIDHFKAINDTYGHQVGDAVIQQVADLIRENLRESDVAGRYGGEEFVV
LLPDTDKQGAMTFAERLRHAVESHEVQHEQHRIRFTISLGVADLSEPTSSHAQLIEWADS
ALYASKAAGRNRVTLHQHDA
>A0A5P9JJ14|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MFEQTLEANRAYARKLADTTDQFFLNSRRELAYAAEVLSTRFDDPAARDSETERLKLNSE
QFSRAVIISAAGEIVSASPESASLVGLKVNSAGATRALQERIPLISDPYIATDGTYLIAV
THPIFAPDGRYLGFISASLFLRERNALHGLLGVHYYRDGSYLYVVDKQANLIFHEDGQRV
GQNVASNAVVQQVLTGREGSQRVTNTLGVDMLAGYAPVPSTGWGIIAQRPTAAITAKLER
LARTTLMNAVPFALVSLAVFWWLSKLISAPIRALADTAEHWSAPEAANRISRVNSWYFEV
SRLKVAMLAGVSLLQQKMGALEAASMTDPLTGLRNRRGLELALKQFELLDQHYAALALDI
DHFKQVNDQYGHDVGDDVLRYLASVLRECSRPSDVLCRMGGEEFLVLLPDTDAAGARIAA
ERLLVRLRYTNSPTGAPVTASIGIACSTSNDSPDATFKAADEALYQAKRAGRDRVVLACN
>A0A1C6DLN4|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MDNLKLVNDGYGHSEGDFSIKSLALCLKEAFGENGIVGRMGGDEFAAFILSEKTEGIESI
IGKKRRYIEHLNRTANKPYHIDMSMGFCECVCENSYDFKEAVDKADGKLYDNKTERKRRN
KNKVSETEH
>A0A1C5NSL7|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKIKKEINLFAGMFTAEEIYRYGDIILLLGHIIYLVLFYRFGVYQMVYYNYFSVAFYAVM
YFLLHFKKIGKISFTYLVLGEIIVHACMGAYYIGWSAGFTQIMLCIIPIPFFITQNRKAI
PYILSSFDVVVFIVMRIIVTNRVAPYSFDTNRENILYIYNTLCSFIIIIYVSSIYIFTNE
HNKREAKAQNEKLQKLATIDPLTQLFNRRAMMDFIKKIESNSRRTNSVYSMCLGDIDDFK
HVNDTYGHEVGDKVLRVVSDVIAGNVPSEGYVCRWGGEEILFVVPNTDTESCEKIAKSIC
QKIHECTFKENSRSFNISMTFGVYSVTPNENYDEGISKVDKLLYKGKNQGKNCVVSK
>A0A8H9ET88|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A7U8WIP9|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A1V5DVB5|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaU1.Bin208|TrEMBL
MYQTIFENTGNATVIFDEDTTILLANAEFEKLLHYTREETEGKKSWRDLVLEEDLERLMD
YHRRRRIDPESVPQKYELKLADRHGFLHDVYMTVAMIPGTKKSVASIMDITPLKEAEKAL
HESETLYQTLFANAGIAIVNLDPQAYYRHVNDSYLEFIGYTWDELKDRQMTTEIVHPEYR
GRIEKLIARQKSGAINGFIEEIYFLRKDGALRWGEVRSASNRDKHGRMLSVVVAITDRTE
RKKTEDKLKQYSEAIKDLFENAPCGYHSLAEDGTILRMNRTELAWLGYSRDEVIGKMKFT
DLLPPEEQEIFRKGFSALREQGSIRNIEGKLIRKDGRELSVLIDSSVLYDKDGRYLMNRS
SVFDNTERKKVENALAESETMYRSLFENASIGMFQSTLEGKFLRINKAYATMLGYESKEE
VIATITDTATQIHADPRNRAELLAALEQQDWFYAEQPYLRRDGSLMIGKLAIRKVVRQDG
ASAYLEGIVEDITERKRAEEALINRERELRIKAQNLMEVNTTLKVLLNTLERDQEELKER
FLTNIQKQVLPYLDNLKKSPLREDQLGYVEMAEAHLLEIASPFTQKLTSSFLNLTKKEIQ
IAYLVKEGKTSKEIAELLNAKQRVVEFHRENIRSKLGLKNKKGRLAMLLRSFS
>A0A3S0IES0|diguanylate cyclase|EC 2.7.7.65|Azospirillum griseum|TrEMBL
MSDTTSSPSATELLGVVLDEHLRWIGQWHRAAFFRDGVGGERPSAPAAFAAWCVAANRDD
LVHQPAVLKLANLHEQMHRQAKLVLLKASGGDTPSEGEYEAVIARFEEFVLHLRRMERAF
GAAASGLDPLTGLRTRRGMMEALEREHNRFHRTGQPYCLALADIDKFKSINDTYGHDIGD
RVLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETEMEEGFAVIDRLRLDLMESPVLLAD
GREIPVTASFGLVEVEDDASIDDLLIRADRALYQAKHAGRNRVIRHGVDRPPAVPASKPA
RPRA
>A0A2C9ERU5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MENQRGKGLSFARRIYRPRIIGLGIGGISVFATLYPLALPSWIWALLLFHGLLWPHLAYQ
LSTRSAFPYQAERRNLLYDSMLGGFWAATMQFNPLPAVTILSMMAMNNVAAGGVRLFIRG
ALAQGIGVLLSWSLFGASFNTRISPLQIYACLPMLTLYPLAVGMVCYRLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLHIKFHKCQQQQIDASIALIDIDHFKAINDTYGHIIGDT
VLRHLSNELRRNLRHDDLAGRYGGDEFCVILPRMDRQQALEVMERLRQVFSQYRHPQVAE
LKVSLSIGLAAFDREFQDPSSWLNAADKALYLAKNSGRNRIASNDDEAHSRQTQMA
>A0A1S1VAM4|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MDELSYRKIIDDMPIGYARHRIILDEENRPIDYQYIEVNRSFEEQTGLKREDIIGKKITE
ILPDIINSDFNWIEFYGEVALSGRAKEVEQYSKPLGRHYRVKTESPRHGEFITYITDITN
EKKEVEEKLRLLMASSDIVIELDENYIYTDVLVEDERSLFATKGNIIGKRVDELLGDELG
ESVLNTLEKAKSSGKKESLVYKSIVEGDDRWFYAEIKGISYDKALKFVISVHDITEEKNL
REDLLKSQAELEGFFEVNLDLLCIADLEGRFIKVNREWEEILGYSREEIEGSLFFDYIHP
EDLEGTLKATEKLSYGSSIKGFVNRYRSKDGLYRYIEWRSNFENGYIYAAARDITDRINL
ETRLEAEKEFLRRMLLSIGDGVLSIGSDNRVRVINKVAKRLLGCEGSGAEGKLLGDVLEL
YSLEESDRIVDLNLCSPEEFGELREGLLKSKNGREYVVEYRLNNMPKTDKCAEGTIIVFR
DISAQKEKQEKVEYLSYHDQLTGLYNRRFFEEELKRLDHSRNLPLSLIMIDVNGLKLTND
AFGHKAGDQLLKRISETLKRACRADDIISRVGGDEFAVILPNTYEREAKSFVGRIYMEAK
KEDINHIVVSLSAGCGTKTNINENVEKALKRAEDGMYKRKLSESPAMRKKTLGKVIAKFF
ETDITGRKHSKDVSEIMGKFGEAMGFDAEKVEQLRMIGKVHDIGLIVLDSSTLNKSDSLS
EREIEEIRRHPEVGYQILRSVTHLAPIAEYVLSHHERIDGNGYPNRLKGEKIPLESRMLT
IVDAYSAMTNERVYKHKLNRQEAIDELERNMGTQFDSELTRVFIDKVLKKQRAK
>A0A1R4B2D1|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MHTISMLFNELGEKVAASSQRASDIVSIDDLIFHQLDNKQVLSFASLQSRLMKQARIDVS
IYFQGDHYIGDVIRMEYTGNTQTVFVVNAKYIAQRAHISTDDSNNIINSTDIAPWEWDIS
TDIIKINEHWANIQGFALDEISPVTATSWKDSLHPDYTELFNYELQRHFKGETRQFEIEY
PIYSKDKDLVWVKDFGQVVARDAQGQPERILGTRLNLTNVKIAQFKLNDLQQQLDNLMDL
SPSLTYKMCADADERIQFITQSTEQLLGYDVDDILWQPKWWRQRIAPQDLWEYDRCRDIA
KTRLQQPIMDCEYRFINKEGEEVWLIDRVRYVDNGYESPYFIGTILDLSEFVTLNQHFKT
LSLLPPGVIYQFQQDKNGHYSFPYASDEFENIFGVPVEEAARDANIPFSMINEEDLAGIH
KEIERSTRTVTESNAEFRITRNNLTRWYFFQAKPAKQKDGSLLWSGQIIDITERKALEQQ
LEQQAITDDLTGVYNRRFFMEKAHQMLVGCQDSSRPFTLLCIDLDHFKLVNDTYGHFCGD
QVLIEAVKKMQSALRSDDILARIGGEEFIIALANVTLDNALDIANRIRRDIRMFTVFCND
TPIFQTVTIGVVESEPDNTLTELMKRGDNALYLGKKSGRDQTMTG
>A0A1R4B7S4|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MKTDLFPCGLMITSLHDQTILHTNEYFDKEFGYTEEALISQPVSYLFTRASIIFLENYLY
PMLIQDRVISEIQIMLVTADKNRIPVTVNATLDEDNLVRWALFCSINRDKLYQELIDTKN
KLEQQTQELTILSSTDDLTGLLNRREASNRANKMIEQTKRNDIALSFVLLDIDFFKKIND
TYGHQEGDRVLVELAKKLENTARSCDIVSRWGGEEFLIVLYNTPTNQAQAFCQRLHQAID
MIKVGKETLKVSIGVSCYQKEIQDNQKIDSIIRQADNALYCAKQKGRNQTYVF
>A0A1S1V7J3|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MPDRFAMGIHVNMLALAVLALIALNIRRRPDREDYVQKTYWAMVMANTVMILIDIAVDTL
NGRDGEALRSLHIGVETAEYALIPLVGMIWTTYVEQRIDRYGKISKMKLALIAAPFAINF
AIVIMNLGRGFMFSIDEMNVYSRGEFFWINVVISYIYLVYSFVRIVKNRDSIRRSDYRSL
LIFPLLPFLGGILQSLFYGVTLIWTSTAFSLLIVFVNVQNDQLNRDHLTGLYNRRQLDGY
LTRHISSAERERLLGGVMIDVDGFKDINDKYGHVEGDKALEYIGEILIRSFRREDFVARY
AGDEFMVLSKVEDYGDLERIVGRLKESMDSFNKSNYLPYRISVSVGYDILDKDIYKTSEE
FVKHVDKLMYEQKRRIT
>A0A1R4B124|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MPLSSNTPSNLKPVFIDKLRKSAIRDLFIIAGVFFTALSLVVVFHLEPSEQLLANVKYNN
LLEINEILLLIIFSGFCAFIYIWRRFQDIKLINKEFVHKAYFDDMTQLPNRALAFERLKK
QMLHTRRGGHFAVAFIDFDRFKVINDTYGHHVGDELLRQVGKRLASVVMEGEMIARLGGD
EFLFVSPLDESCDIEAVMARIKSTRKETFTISHTELNVDYSIGVAIYPDDGETISELLKS
ADTAMYHAKLQGDEYCIYTKPETKSLSFH
>A0A136WD20|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MNTSIVEINVLGIILFLLLMIDGKRSMQIQKNNKFFYRVIFFTVLALTANTLLYYSVSLQ
KTFFFQYFMVIVYLISVEMGAYYWLSFIFHELLPEEQCNPSAHLLYILPIFFVSIMVLCS
PYTHWIFYINEKKQYIQGNLYFLQNLVVYGYILTGAATSLVLYKKEYLIEKQKICFYLFL
YSLFPLLGKGIDTLFPMLHITTAAVIISIVMLYLCSLKKEIHLDPLTQLNNRRKFEQHLI
QITKASKNKIIFLIFFDINNFKIINDSFGHVEGDKALIIVAQVLKKVFSDTKAFLSRYGG
DEFAVIMANEDGDALPYIEKIDASLVEISASLPYTLSLSVGYSVYGEDNATTIESLVQAA
DKKMYCDKQQKKQNLC
>A0A0P1EJ11|diguanylate cyclase|EC 2.7.7.65|Ruegeria atlantica|TrEMBL
MMQASELSALLDTLCPMFVMVDDKGMIVNAGPTLQKLRPVHPMRGRGFLDVFELVRPRTI
TTISTLLSLTGGKVHLKFHDEPRTALTGLIAPLPKGNGAIINLSLGISILDAVRDYALTS
ADFSGTDLAIELLYLVEAKTAAMEASRSLNLRLQGAMLAAEEQAVTDMLTGLKNRRAMDV
VLGHLISANCAFALMHLDLDFFKSVNDRLGHAAGDFVLQQAARIMEEETRTEDTVARIGG
DEFVVIFKGLVDESVLSDIAGRLISRLCQPMMFQGTKCKISASIGTALSTQFGTPDAAEL
LNAADQALYVAKRQGRSRHCLYSALAASGLKPASSQ
>B7MWE3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O81 (strain ED1a)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVVQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A6I7LPV2|diguanylate cyclase|EC 2.7.7.65|candidate division Zixibacteria bacterium|TrEMBL
MAEKVLITILAALVALLSGLILARRKREKGKILVSEEAVNDLVAGIVNNIKAGKIQDIAG
RVSMTLKKYLGCDKIVFLKQSRGQLELNYYYGIQKFNRDDFKLKFGQNLSGRLNSTFSIS
SIEELKPAVPDNYLSRLVTHDLKYFFPVYLRNNLYGVYFIKTALQPDNPVLRFLATALAF
NLSAAYHIGSQEQQIRKYEDRLKILNNSKNKEGNHPDSLLGHEMSRLLKIKDSRQLIPEL
LTALRKECGFSKMAFIAPSNRADQTVILINWNVAENSTRLIKDSYSLLDKKIEQENICDL
GDSEKLGEPLSEKMNQLKELDLRYMTALSWPGSRKAFLAWNGGKVPXDVMNRLQQFKAEA
LPLIENVNRYERIEELSYTDGLTGAYNYRYFQRQIREEFGRAKRYNRNLALLIFDIDDLK
MINDKLGHQVGDELLRSFGKILSESVRANDVASRYGGDEFCLIMPETDRTKVRQFMDRIR
DQISRSPLPLESGEKQPYSVSIGGAVYPEDAESVDSLINAADMALLKAKGEGRNCSRLYM
PEYSHRE
>A0A5U9QT17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICA
>A0A210PC34|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MLTKYVLQEMPLLTSLFFIFGVFIIYEILFDGVRSVLSLKEINIESSILKAQLGIMYLFI
LLFGLQALVVNHQATWIFINFQIIALIFCAVFLDAPVNYPIFIPIVLAFMIFNSAIFYWE
SWCFALTLFLFYYSLKYIKKKRTNPFPFIYYMLDGLFFGTILWSLARIKFSLNGATIFQQ
VSYLIIFEIFVYCYIGFFVRDVRVKHTLYEFAHLDALTHVKNFAAFDNDIHALFNQHQSN
DINVAMIMFDIDHFKSINDHYGHLVGDKVLQQVADITQTVINANDRNIRFYRTGGEEFNI
ILPNYKLSEIDSITQEIFTAINNSQFNFNNQTVDVSVSVGSSEIRKNDLNSDEFYSRVDD
ALYQSKRNGRMRITKS
>A0A518JV48|diguanylate cyclase|EC 2.7.7.65|Rosistilla carotiformis|TrEMBL
MTDNRSNNENDAFAIAKDALRLIGQFKTPPTPNVYGVWYRYVEGHDTELIRKLSPAVTEA
QSVSVAMLESIHSQTANAADETNASVGEALIAELDRFQSLITQQQAAGTEFEGTIDTASK
LLNADDSSQQSSADCIAVINAGATAMKRQLHEASQKLDAAQSQIAKLQTELAQSRRGMMT
DHLTGIGNRRYFDAQVRQTLKSLRYCSGSVYLILMDVDHFKHINDSYGHDAGDQVIRFIA
MEISRRHPNVSLARLGGDEFAVILQTSSALAAVEFADQMREHFATQQLNIMPARTPIGSI
RISMGLAKLTENDDEKSWYTRADGMLYRAKGMGRDQVAIEEECMQV
>A0A654CX09|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. T1|TrEMBL
MNRIAHRVTELTRFAALPIATGVGYYLAAFASLYLTRGADGIAMLWPPSGILFAALLVEP
RNRIVWHIGAAAMASLAANLGGGNGVLLSIGFTLANVSESGFAAWLLRNRTRRRDSFTDP
KGLVWFCIAAAAAAALSATIAACATTAVGISFWLSWFTTDLLGILIVAPLILISGRAFYR
KRFRDGLAAAPQAIAIFLLVASVSIIAFSQVNYSLLFLPMLAVLLAALRMGPFGAAGSVL
IVATASSLAHIFGSDPQAIADGQAYARSIFLQFYLLALFAAALPIAALLATRQQLIDSNA
NKLRLLELAEGAAHVGHWHLDLLTQLITWSDEVFRIHGVENRVPPSLDTAIDAYHPDDRD
AVSAHIGRSLEHCVGFEFTARIVRPDGEVRHVFSKGEIDRNGVNESIGLFGIIQDITTQV
AHEAEIERARTRAETAARNAIILAETDQLTGIANRRRTSFVLEQTLLLARETGHPMSVAM
FDIDHFKRINDTYGHHTGDEVLKRVAAGAAAELRSGDTLGRFGGEEFVIVLPDAAADAAS
KVAERVRHAIGTDNCTPGVTVSIGVAEMAPGETCDALLRRADDALYGAKNEGRNRMRLAA
>A0A1W6KD23|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MPAKSPALVRVSRRSKLPVLIRATDVLLGLDAIKNLLGSVSVGAISLYNHYTDTRARKPN
RRAVDSLPLGPMQTASSVFTSVVGERFYVFTQTPRPKRFSIKMWSMTWPLMPKNNKTATM
TQTTSRPSDTKLSQFRVKGEIPVPMLIGWLTLAAVPILLFFAWRSLDRGIPGSATALIVF
AVLLSVNGIVYLLSRNSTLQRRGFITAITILFTYLAVNAVEDGSAIIWLFAYPPIIFYIS
EAKVGVLACSGGLAGVALLFSPLGDLVFDSPYSTSFRLTMLAVLGFEMSTCYVLDQSRRR
SKLGLLKLAAEFEYAAKHDALTGLANRREAHEQLEAEYQRYLRNSRGFSVLLMDIDLFKS
VNDNHGHQVGDETIVMVARTLREHSRKVDTLARWGGEEYLVLLPETDTVEAVQTANRIRQ
TIASTPIETQGGSINTTISVGVATIHGAESVDRLLQRADEALYRAKTLGRNKVCDFEGIH
G
>A0A4Q4ADB0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNASPLVAEFYRVVLADPSVAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHTPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLSGQDLNDKVHRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHATRAGTMLSTLLIDVDKFKQINDTWGHNTGDEILRKVSGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEVDTLRIAERIRKRVEKIKVNSPTGEIIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKGA
>A0A240EJM8|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MKKNDFQKSAANLKKAVPLMVKHHVPATPANYALWYTYVDQTIPELNAEVDAILKDFDIL
PLVNTNLLYREHIAGKAEVNLQDLKHNMEALVTEVSSSMTDVIADTSQFSKVLEQSFDEL
STQMESPRNPTLDEVMPLIQQLVDEANDIRHSTDFINDQLKNASDEIARLKSQLAKVQCN
ALFDSLTSLYNRGAFDADLNMFCEAKQPMSLIFLDIDHFKTFNDEFGHLFGDTILKGISQ
RLKQACRGGITAYRFGGEEFALIIPNKSLRVARQMADALRLAIEKMTIKDRKNGSKVGNI
TASFGVAEFTTGDTYSSLVERADKMLYDAKRAGRNRVMPF
>A0A240EIK3|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MMPSNQIELFPWNTNFETGIPVIDEQHRNLFSLINKLANALVYDNQLQVSTIFDELADYA
RYHFSEEEHVWQQYFEHDSWCQLHKANHESFLPEILNLQSRTKESGWHEATEQILHFLIR
WLLLHILHEDKKMGLVLSALSDGAIDLQQAKIAAEAKLIDEHGTLTDTILNMYFELSSHA
IELIREKNRRIIAEKELKALNDKLQKLAVTDELSGLFNRRYFMMMTPETLLRAKVENSKL
SFISLDLDNFKHLNDTLGHVKGDEAIVQFSRVLSSKFCRESDYIFRMGGDEFLVVVCGSE
HKQVMEIAEQVRSAIESLTSNDAAEISAITTSIGVFTHIPEGYEDFMYFMERADQLLYQA
KEQGRNRILSVEE
>A0A0M3F9G7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHENRVRKPPFFLRQRLHPGRIVTLCFVTVLIFSTLLTWREVVVLEDAYISSQRNHLET
VANSLDRQLEYSVDKLLFFRNGMYDALHTPLISGLLRQSVARFSDISAQPSWQLTFDEHR
TLPLNGVSDAFVMQTVSLRRDEMLIADELRAAFEVGYLMRITSPLAKLARRIMYVSRAGF
YVSSNIADWGGAIPSRYYHLVTSPWFTQQSQSSNSSRGVRWFTRPAQSWSGDEQTVTVSV
PVDHQQYWYGVLAIDFTVTAVGQMLSEALDGYEDGEYQLYDNQLTLLVSSGKQAERISLF
DERERAQLAYALEHDNEGGVRLGSRYLSWHRLNHFDGVLLRVHRLDEGLQGDFGRISVVL
ALLWLLFTAMLVGSWLVIRRMVSNMYSLQHTLQWQAWHDPLTRLHNRGALFEQAKTLAAG
CQRQNQPFSVIQMDLDHFKSINDRYGHQAGDKVLIHTAGLIVSTLRESDVAGRVGGEEFC
VVLPNTTLAQASQVAERIRARVNRREILVQKSQTVRISISIGVSCAGEKGNYEFEQLQSI
ADARLYQAKQRGRNRVISQDEK
>A0A7Z1AGN4|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MKYLVKMYISLIESLGIYTTDQLYELISTKQHGMPISRHRAAVMQSRVFFFSVIFAVLVP
AWSVIDILYLPQALWSELLLIRLLAAASFAVIAWQTRREPDLMLARMLLAAMLAITPLFY
LLSDQIIADQQLGGTATILAEVYALLPFVMVAGLTLFPLAISEFLSYAVPIFLVVVYSVY
PENPAEIAEAVSTLWLLILLLGVGLFASMTQLRYMLSQVSHASYDILTGMLSRRAGIEIL
ELQFRLALMSEKPLSILYFDLDNFKAINDTYGHDTGDTVLRVASQQIRDTVRKGDSVIRW
GGEEFIVVLPTADHKEANDVITRIMLAGLGNRPDGSPVTASIGIAEVQQDRLKDWKSQVE
LADHRMYTAKSNGRARCIGVGGQSTEWVTALEQSAGF
>A0A517NRL5|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium K23_9|TrEMBL
MLRAYKPFSDFDSAAQSLLDLLHEQYGFSLWMVTRTDGVDWTVLQSKQHTYGVSAGDVFS
WTDSFCSRMVQGLGPCIAPDARSVDAYADAPVSQQLDIGAYIGIPLSRPDGSLFGTLCAI
DPQPQPADLVDELPRLIMASRMLSTILATELKAEAEMRRANHAEAEAETDALTNAFNRRG
WDRMLSAEESRCHRYGHIASIIAIDLDDFKNVNDSQGHSAGDRTLMQVAQALERASRACD
VVARTGGDEFAIIAVECDEFQSAQFIRRIKENLSQFNIQASIGTATRSPTMSLDKAWIQA
DKNMYEKKQNATGILRALGHRDDHPHVSRPPITRSPIV
>A0A8J7S1Y6|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MTRTLKEESRDLRSSFEVLTDRTYSNMLAMATFIANDSEMQSLFLAGGKAVEAEGGGAGG
PKAAGIRRELFERIGPSWQRVQDRFDVRQLHFHLGPGSTSFLRVHRPDKFGDTMHDVRHT
IVDTNAEKSPRVGFETGRVYSGLRGVVPVYATDPDSGEHVHAGALEVGTSFSNIIKILDE
RLGQGVGILLSMDHIESAMWPDFVKERFGEGEPGCDCAIEAQSREGLRPILAKMPELGLD
FRDEDTNIVETDETIHVVTHFPLRDYKGMREPDREAVGAVVFWRDATERITAHRRAALFN
IVYGIVGFLFVELLLFMAFRFATERLERIVANQTKDLEGKARQLQELSITDRLTGLFNRL
KLDSAFADELERRKRYHNALSVILFDVDHFKRVNDIHGHQAGDRVLSDIATLLRTSVRQV
DIPGRWGGEEFLVICPETTLEGAMVLAEKLRGAIAAHDFGEIGQVTSSFGVACHDVDESE
DSLLARADRALYRAKEDGRNRVMAG
>A0A381F079|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MIRPSPALFGSFRLRLAILFGGLFLASALLAAACLDQVLSDRIVRDQGEAMNSLAANIAK
AIESNLRERHREVLLLAQTPTYVRAPLDGDDVRQSLERTKQAYKYYAWIGITDAEGKIVS
AAGGMLVGQSAAKRPWLIHGRHAPFVGDIHQAVLLAKLLPNRSPQGEPLRFVDFASPVYD
PSGKLRGVLATHALWDWVEDIIRERLPPKSGLETFIVDRQNNLLSPFDAVGRMQAPTPMP
SGQTFRLGPWPGGGNYLYSESRVREAGLDWRVVIRQPRQQALAALNRLRGALMLLGLAAS
ALLMAAVYRLAASFSRPLEQLAGVAERVGRGDEQPDWEIRGGTQELRQLSEAMRNMTTTL
LARERQLANVNANLEQMVADRTEQLRESNRLLVQKATQLAQLARNDALTGLHNRMAANEQ
LQEEHLRHGRSGAPYAVLLLDVDHFKRVNDTHGHDAGDRVLRHIADILRRAARATDFVAR
FGGEEFLLLLPETDADGAAVLAEKIRASVEQSQAPDVGRVTLSIGLATVVPADSQPEMAV
KRADQALYRAKAAGRNRVEAAARED
>A0A381F0R7|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSGPFSRYRLAIIVALLLLAGIFVNAGLYYRQGSQDIRHGIVEQGLPLTGDTIFSEIDKS
ILRPLSVAALMANDTFLQDWLKDGERDPERVARYLAAINGRYGITGSFLVSENSRRYYYA
GGVLKTVSPADREDVWYFHSRQIKEAYDITLDEDMTNGGKTTLFINHRMLDGKGKLLGVI
GVGLPQLELSAQLAAHEQRFQRRIYFIDRSGRIVLDSSGTTPRRLAEQPGLANLASAILA
GGTEPKKLEYSRDGNRYLLTSRLLPELGWHLLVEQNETLALQPLHAALQVNLAINTTILL
LVLIAVLATLQHYQRRMRQLATTDPLTGCLNRLAFLDLLPGWLRACERTGAEPQLLMIDI
DHFKQVNDKHGHQIGDQVLREIADLLRSQLRGSDLLIRWGGEEFVVLVGSHGEDDALAER
LRTAVARHVVSASGKRLTVTVSLGLCQWLPPETLEAAVARADLALYAAKQGGRNRVCHAA
PYQPIDEPIA
>A0A564TG61|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQNLTFSQLRIGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSSRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAITGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1Y0HR48|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MRLKTKVVVIIAGLLLSVSITGSIINYMKNVQDTQAQLQNTSLPLSVDNIYTEIQQRMIE
PLLVSSLMSHDTFLRDWLMDGEKDMDGIVRYLTEIQQKYDIFTTFLVSDKTKNYYHPRGL
IDVVNKDNSADAWYFRFKDQSEPYEINLDHNANLSDTLIMFINYKVMNYKNEMIGVTGVG
VRLLNIEKMLSSFKTKYKYDVYFVDQKGEITLFSQALNKRGNIANIDGLKSIKEAIYKGE
QTQFEYKNKEGEYLLNTKYIEKLKLQLFVEIDKKEYLKELKKTFYANLAISLLVTLLVTL
IIIYTINIYQKQLVKMASEDSLTGLANRRKFNEHFEKFYKLYKKGINSLTLMLIDIDDFK
EVNDTFGHLVGDEALVRVAEILRVELRSSDMVARWGGEEFALLFVDVSSEKSVEIAQKIC
QAIREDKVLSSLLQRPLTVSIGVGHLSSLESQDGLVYKVDNALYEAKKAGKDQVIVA
>A0A7V8THK9|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLTDLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEVMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIITETDDYIRSHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDNILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIHL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A1Y0HM32|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MKLYNKILFLTIIQLSAIFIFGIYEMQSLYLTQKKAFDQNKLLQMEMIQKRFEEKLDQLQ
KTAEILTNSQEVVTGIISNDTDMLFNWSKLFLSSSINKIHFMDMDGMIISRGESEFRFSD
DVSKRFYIQQTLKNDTFLGIDLIDGEECLIYAKRIKQYGTKPIGIISVALVIDQELLSVL
VQGTMMNITYHSEHQTLSSNKDQKLIDISSLHVILESGSIKDVSFTIGLASEKELIALKE
ARTNFFIGIAFALVLLVLAIHFTLIKSLKEYKALSQVLIDFYEDRLDIQEVITTIEQTTQ
KNTTPEVKKISEALFNMSQKVAETQKALELLSSTDQLTSLSNRRKLEECLEQKIKEASRG
SFFSVIMLDIDRFKTINDTYGHEIGDHVLTHMAHLMQETMRTSDLLGRWGGEEFLLILPQ
TDLEGALLMAEQLRSKIYNFTFERYPQRVSMSLGVTHYHKGDTPNSILRRADNALYRAKN
NGRNRVEHDA
>A0A5K1ICA1|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MSLKTRFLLLAACLVLVASAAAWTVFHRITEGIIEQWGERVAAIQVQYDSGRLLQPLERE
IALARQMADSIVLQRWANAPDDPELEGQAFDEMESFRRNFRDNSYFVALRGSGGYYHNNA
AGDYTSERLRYRLRPDRPADAWFYRLIEEGRDFHLNVNPDVELGVTKLWIDVLMRDADGE
ILGVVGTGMELESFLQEIIDIQQPGITTLFVDYNGAIQLYRDRRLIDYASFIKPEGQKRT
LDLLVDLPRDAEALSGIMQELRDAPDQQPSVRTEFVTVEGKRHLAGLAFLPALGWFEVTL
LDLETLMPLGGFTPVAVVFVLTLLVTLLVFHLALRRQLLAPIAALEAAMQRVKEGDLSAS
ELPRGRGEMGRLMHHFRSMAEAIQRHTRDLEERVRERTEELEAVATRDVLTGLMNRRGMQ
QWLEEQILRATRESSHFGLLWLDIDRFKELNDGLGHAAGDKALVRVAEALSDGLRPYDRA
SRWGGDEFLVILSPCDAPTLAGVAERLRHAVAEIEVEGVPVTISVGACMANPGEDLDLLL
KRADEALYQAKADGRNQARVAV
>A0A1Y0N7T3|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MAHISGIADSVSLVAHFASLYEHSPLHVVLYDPQDMVRYANPAHCTDFGMARDAVMSWTD
MMRHSYQNQVGAAINTHDLEAWLVSAKARRGKLPFRTFETDLRNGRWMYITETMDDQGWM
LSVGFDITALRANDRSLRQARDGALRAAQVDTLTGVSSRAHVLEQLDLRLNQLRSTQQPC
GLVLLDLDYFKKINDTYGHTAGDEVLQRFSRLVVGTLGRNDGFGRIGGEEFLLLFPMVTA
AEMEAKVQGILELVRESSPLPEVPRFHHTCSAGLVMLDPALSAIENMRNADRALYAAKGA
GRDRLMWA
>A0A1Y5T789|diguanylate cyclase|EC 2.7.7.65|Pseudoruegeria aquimaris|TrEMBL
MAAFSPANIPPEGLNRLMPMHVMCDAEGLIQHIGPTLHCLWPFGAPLGRPLFDVLEVNRP
RGIADFPELLARAGERLHLSVIGEEAPKMKGLAVPLLDGGALLNLSFGIYVGEAVRRFDL
TDADFAPTDLTMEMLYLIEAKSAAAAELNRLASRLQGARIAAEEQAFTDTLTGLRNRRAM
DVVLNRLISGGQRFGLMHLDLDYFKDVNDTLGHAAGDLVLQHVARVLVEATREEDLAARV
GGDEFVLLFSGLTDIDQLNAIASRIIERLEEPVMFEGKPCRISGSIGTTISDFYTEPEAE
VMLHDADIALYASKHKGKACFTVFSKDLGQLEPPKGREKAPSSPAH
>A0A7L6LCY0|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTTINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISTINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNAGRGQV
TVYEPQQVTAHSAQAAMSLDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A839BFI1|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKRSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGSQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNVAASVLLFSTSSLNMTWTAINIIEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVVLLVPDDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLSITLALSWLSMRYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMLAADPALLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGIEGQWLQSNKSLCQFLGYSQEELRAITFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPSHVKPNWQVWYDCVL
PEDRGHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDTLTHLANRASFEKQLRILLQTVSSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLNLLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISTINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNAGRGQV
TVYEAQQVTAHSAQAAMSPDDPWMMIKENHLLLIAHGVASPRIPETRNLWLISLKLWSRN
GEVINELTFRRSFSDPMLNLALDRRVLHEFFQQAANAVASKGLSIALPLSVTGLSNTTLV
DELLEQLENSPLQPRLLHLIIPAETIFDHAENMHKLRLAGCRIVLSQVGRDLQIFNALNA
NMADYLLLDDELCASVQGNLMDEMLISIIQGHARRLGLKTIAGPVTLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A6H0K8N4|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei|TrEMBL
MNKTYQRVLVAPNRPLLHLVSLGLITFIFTLFSLELTRFGATLAPLWFPTSVMMVAFYRH
AGKFWPGIAVVCSLGNVLASSILFPPTALNLGYTTINIIEAVVGALLLRKLLPMYNPLQN
LNDWIRLAFGSAVVPPLVGALLLLMFFPGERPLESVFIWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLVTLAVTLALSCLSMLWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
STVMMVSLLIAANPGILETPHQYALDNAAWMPFLMILLPANVMTMVMYAFRSERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCRFLGYTQDELRALTFQQLTWPEDLNSDL
EQLEQLVNGDIQSYSLEKRYYTRKGDVVWAMLTVSLVRHADGTPIYFIAQVEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELEPDVISWDKRMFELYDVPSHLKPTWELWYNCVV
EDDRDHAESTIRNALSNRSPFKLEFRIHARDGVRHIRSLANRVLNKNGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVEMNVTFMNPVAEKMSGWSQEQALRQPL
LNVLRITFGDAGPMMENIYSGDFSRSDIEQDLVLHCRNGGSFDIHYSITPLSTLDGQNIG
SVLVIQDVSESRKMLRQLTYSASHDALTQLANRVSFESHLKRLLHTVYENHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSALMLNMLRTSDVLARLGGDEFGLLLPDCNIESARYI
SGRIIKAINDYHFLWEGQHHRIGASAGITLIDENNNLATEVMSQADIACYASKNNGRGMV
TVYSPQQENLVPRSMMSQEEKWHIIKDNHLVFMARSVASPRVPEASHFWLLSLRLWTSEG
DMVEERAFRQSLTESEQLRALDSRVLQLFFHDWSAKVAAKGISVALSLSTAGLARPALID
DLLNQLNQRQIPARLLHFIIDSEVMLSEETLVRQGIARLREAGCKIILNHIGQDLEVFNQ
LTPEMADYVLLDPDTILNVHLNLMDEMLVTIIQGHTHRLGMKTIAGPTNESLVMDTLSGI
GIDIIYGDTIAQNQPLELVLSSSYFAIN
>A0A839BC11|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVAKDASKPEITDNHSYGLCQFGQWIDH
LGPLDNDELPYVRLMDSAHQHMHICGRELMLAIVENRWQEAHFDAFQDGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAIAH
SDGHINITVTAGVSRAFPEESLDAVIGRADRAMYEGKQTGRNRCMFIDEQGVITRV
>A0A1V5T9Y9|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin269|TrEMBL
MANTIDILAQFKQLELSGALDKLEELRRENRELERIITEVGTLISYTDMNAMLDFVISRI
LDHFIPQFFAFLIHPPRGPELRQYCYRNLQESNDRIPEVYYSILRARFSRTPAAASFSEL
DDELGPEQFSQEFRSFEPQYLFPMSGIGGIYGVVILGKKLIGGEYTTREQHYVLRLTKVL
SVCIQNGLHYESSITDPKTGLFTHDYFMSQLHTSLANLTRHHRPIGILMLDIDHFKKFND
TWGHMSGDLMINSVARVLHSSVRTEDCVARFGGEEFSVLVMECTAQSLFRIAERIRKAIE
GIRLKLETGTELTATVSIGARFVDTQSGPPKNADNSPQCLSTSLQDAQLHHGSQSITDAA
RLIEEADIALYYSKAHGRNRTTLYAKGLLERAEFCVFRNTDQHTEYPQTNGHQ
>A0A645GW03|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MDHSYGDELIITVAEVMKKQIRDEDLAVRLGGDEFLILFKDVDADESEKIWSRIVANFNE
INEKEKRPYIISASHGIIEYDNNQKRAIDDLITKADEKMYLEKEEIKRDLNVIRPKV
>A0A7W3BT41|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00271|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYGDLPRLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLTDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQALSNQQQPGETERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMCREISLALHSRKPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELRIAASMTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETYRE
>A0A3S3R2Q3|diguanylate cyclase|EC 2.7.7.65|Candidatus Electrothrix communis|TrEMBL
MGKIEQLCITVSVGVAELTGDDRTELVENADQALYQVKELGRNCVVVWE
>A0A076JGW5|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium coryneforme|TrEMBL
MARILAVDDEESILDIIRIGLGKEGHQVSTVSDPRKVDMLHLDYFDLVLLDIMMPGMDGF
ELVSRLREATGVPIIFLTARTDQADVVRGLGLGADDYLTKPFHLDELRARVDAHLRREGR
ARSQVLTLGEFRFDMSAKELTCGDRAINLTPTEYAICEFLAVNRGHVYSKEQIHREVSGL
DPRGEAAAVATHIGNIRAKFQEVGMAPIHTRWGVGYLWV
>A0A0A8UZI9|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MLKTIRPIKLNKVVLNFLFITALLILSVVSYLSYSQLKNLIEANRLVNHTYEVIGKINVS
LYYLAEIESDQRAYLVSGDKNFLREINSSKATLIDTLQIASVLTKDNAKQNEKVRRYKAL
IKERLELLAQVTQLKANNQLNTPEGLSLFNRGSEISSAAKGLGQEIISVEEILLSERNNH
TLQNTKLGNILLIVGSILSIIFLIVPFTLANIELINRKIIEHKNRTTRIHLRQIIESTND
MIAALDAKNRFEIFNEAYQQEFKRLFGKSLLVGMNLEEALSGIPQDRQHLLEIWQKSLQP
DESTKLLEFKHENGKTIYELSATQIKNEQNENKGLVHNVRDITSRVQEHSQLQDSYKKLA
EGMKELQLKNEQITLLVDMSDIMLAANSQEELSKVMAKYAQALLAFSSGYLYIMHPSKNY
LEKASSWGQPHTQDQLITPDQCWGIRLGRIHQIKKADKELVCEHIQITSKHPPTFICVPL
MAKNDIYGLLYIEIAEAKFILNEETRLIIAAFTELTALALANVRLRENLRYQSIRDSLTG
LYNRRYLEDALFKQIHQAERSKFSFALMMLDIDHFKKINDNYGHDAGDVSLREVGKVLED
CTRQGDIAARYGGEEFLIMLHNIDLANAKKRAEQIRTTISKLQIKYGAQPVIPLTVSIGI
AVFPKDSRNKDELTELADKALYFAKAHGRNRVIAFSEIEQSND
>A0A0A8USU3|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MLLTTPSLSYDELRQMICHIDQAIYNHQQWYNAIIRTLICHLPASAIDLSKNAYKDCRFG
QWYYSDLPRGIQNYQGFASIGDSHKRMHELATHLLQITDSGKKVTPVSYDRFANALEQMR
LEVFTLKNEIEFLMYNRDMLTGAITRLNMLPILIEQQELIKRQGKSCCLAMIDIDRFKDI
NDNYGHLAGDGVLAEIANYIIQNTRPYDKLFRYGGEEFLLCLPFTELTEGQKMLERLCKG
IENMDFKFKNKTLVPFTVSAGLGLLDPFLPAAVSIEQADKAMYAAKQAGRNCVYVYPDSC
>A0A1V6DCV5|diguanylate cyclase|EC 2.7.7.65|Verrucomicrobia bacterium ADurb.Bin122|TrEMBL
MQFKVVQEMLRRFQRERFELEWDGNYESALAKLTTGDFCACLLDYQLGTRDGLQLLRDAT
AAQCHTPVIVLTGWGTEDVDVAAMRAGASDYLNKDEITPRLLERALRYALKLGDTLASLR
HLATRDEVTGLLNRRELERILAAERQRAGRFLRTFALLLIDLDQFKAINDTHGHPAGDRV
LRHVAELLLGQTRAADSVARYGGDELAIIQIEGTPADALAAARRLCEVASATPCPQPAPG
EPISFSLSIGVATYPLDGDSVEQLIAAADRALYAAKSKGRNCACLASDLPPPSPA
>A0A6S7D1J5|diguanylate cyclase|EC 2.7.7.65|Achromobacter pulmonis|TrEMBL
MSSSSRAVPSSPEPAGQACYLSASNTHAWQAVYSSVDAYTRGQVAAVVSDSADELVAAFY
STLLADAEAGPRLSHEIVSSRLHQGMKGWLRGLLCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAQRLRASDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNIATERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITGAVARLDDVVLPALLQGGPQALPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTHVLNRRFLPSVVGREILIATREHTSFSVLLLDIDHFKAINDQHGH
SGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGREAALAVAEKLGAEIRRHTF
VIPEAGSLRITASIGVATFDGHPDYAYLIERADKALYQAKQSGRDRSVAA
>A0A514WKH4|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. IC081|TrEMBL
MGGDLRNAPLKEADEDSGDGLVTALKNIVEANADDLVALFYKTLLQDDEAKHFLNYSVVE
TRLTSSLRAWLVELLGPSDIRESPDIQDRQRIVGEAHARIKIPVHLVMEGALVIKSRLAE
LIAVDIDDAAAAIANVQLVNDRIDTAIMLMSKAYMRDATARARLDEAYRLFSLDQDIGIE
KEAQRASLMQWSQETLFALLGGSLSLSKLSTSQFGLWVRHRAGLMFERSPAFENLTAEIG
RIDNILLPKIESGNGRSGDNDALHQLHSAVNEILFIMNDLFQVLNSMENGRDPLTRALNR
RFLPSILGREITIANQNKSALTILMVDVDHFKSINDRFGHQIGDVVLKQVAQVVMENVRP
SDFVFRYGGEEFLIILSETHLNEAKGIAERIRTDLCDRELDAEVPQVLKVSASIGIAEHL
GHPDQNYLIKAADEALYQAKANGRNRVEIAVAMALSENR
>A0A0H5ZS82|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTGIRLLACCGVQICSVFLLIISSSAYAVVEHISDYFVETWTSTDGLPHNSINSIAQTRD
GYLWFATWEGVVRYNGINFQVFDRNPQTGMVDSGTRTLLPMDNNGLLVAGARGSITHRQS
YGWQSFRSAPSLVNGALIDDAQNLWLAIEGLGVVVRPYLGNNLYGPDRWLLTDASVYRLV
KNQHGVIFAATDKGLYRFNDWQASAMELPIGRYERINYISISLNQELVVATDQGVWINTE
EGFQSLFVPLEKEVVTLAEQDRAGNWWIGTVNRGIARLKNQQLQFLEPSRGLPYSRVLSW
YQDIEGSVWVGTNAGIMRLRDAPFININSDKGLVGDYVRTLLPLDDRRVMVGTSRGLSII
EEGLAHSALMPQVGARPSILSLAKADQQGEKVWVGTVQKGLLLWQNGQLRPVLDENNGLP
SSEVRAIVTDPQDNLWIGTSNGIVKRTPQGVLTTYNKDNSPLPDDYIMALAVDSEGKLWV
GSAVGVAYFDAQGKIRPVDLTKQEQAQYVFGFYMESDYVWMATDRGIVRYRLSDASVSLV
GRAAGLPIDKFFQMLRDSEGHVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGDGM
ATSQANGGTNPASASLPNGELLFATAKGVASIKVQRLQQLSELRLPVVLESVSFDSEIIN
PDQQYIAAAGTNRVSFGYVGLGFVMSERLQYRTKLEGFDRDWSYRGHNTQAEYTNLAPGK
YRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIVMAGMLFLALAVSLVMWRIRILKR
RELYLVEQVALQTQKLRLQAEKFERLSKEDDLTGLANRRAFDMYLKQAFSRLQNPDQQVS
IALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYVGDKTRVARWGGEEFTILYVGDPKQ
AWGYFEKLRCKIEQVDLSAVAPGLNVTVSIGFADAQQAESYETVLKLADHALLTAKKLGR
NRVVKSEEWQVKSGLH
>A0A3M3Y2M4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MTLDPPTILTLTIALAAAAALYLAIEWRSVRESSLLFWAAGFATISVGSTLALLRGSGLL
MIGIWFANGLLVTAHFLFLLGVARFTQARLSPLWLLMLLVWLGMLMLPVELPWSKAMLAV
QSLLVAVPTLRASFLLRPHGKSLSIGAVQLRYVLLIHGTFYVAKALSVLIPGTLIDLTAF
KGEIIQVSLVEGAMAIMLIALSMTGSERYRREQQIARLAARDPLTALFNRRALDLQAPRL
LAQVSRAQPGAVLLIDIDNFKLVNDLYGHTAGDRLLVALSEMIRAVVPQGALAARLGGDE
FVILLNQASTAQIVDLGSRLREQFQRLAAQSFSTPVPVTLSIGADLFDQPPLNLSALIEQ
SDATLYETKRGGRDSMRLVDRTGAFGERS
>A0A3U8PI21|diguanylate cyclase|EC 2.7.7.65|Salmonella berta|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3S4VSY8|diguanylate cyclase|EC 2.7.7.65|Fusobacterium varium|TrEMBL
MKIKNIKVELWIISICIFILMLNSIILFPKKVNSFFLNMIESELDSSTERNTELIYGKIN
ETNTLLYGISTDIIDESNIKSEEVKKLLKTVGANFNFRAIGIVDTEGKLVSKIEFSQNNS
DDEFYRILRFENEKDKNVSWSVYKDNVYSKIPIFDREKYIGILFCIFNFKEMFKNLDSIE
REDTIYVYVINSEGKILIRSDNSEILFNDDNYYDWVKRTQNNGEKAIENFKKYFKNNDSK
NMGYSINLLDRVIYFAPLNINDWYIVSMISKKELSQNINQMKKIANIYLGVIIASIVYFL
SIIIYYMRKNHQYIKKQNKKLQISEETLMAAAEETSLIIYDYNIKKKKMTFRNGKKIKSI
FPEVIEDVPKSLFEKGILLEECRKETEDKFENITKGARAITSIFCLRNKNTNEKEWFRST
LSNIFNDKGEIEHTIGMMVDITKERKKELMFKNKSKRDSLTNLYNRESAIRIIKDILKNS
RSKEDIHALMIMDFDNFKNINDTLGHIMGDKVLIDAADKLRKNLRKNDIIARLGGDEILI
FLLNIGNENNIMKVASQIVNKMRDFYEKDEKRIEISVSLGVAMFPTDGKRFIELYEKADK
AMYKVKKSGRNGYYIYSSR
>A0A1C5UJZ6|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MNITSLEIAQATMDMFFCLFCLIIFVSIKANNPKQKSMRMFAQLFLIATVLFFGETLAYI
FRGNLGPFNILVTRIANLMVFAMNIAMANTYVRYVSSVFVEKGAEVSGNSVKIANIFSCI
NIFIVVVNLFYPWMYYFDEANYYHRNNFWYVYTLISLVVIFIGAGMAIKYRKYLKKRSFI
SMMLFSFIPIIATVIQSFIYGFSITNLGLGIGSFVMFAAYMYDWSHNGNEHTNMINDSRF
DAVIMLIIMLLSMSVSIIACVNGIQQVTKENSEIQSRTIAQMVSTKIENEFIKPITVSQT
ISSDIDIRTYIEGKTREEAESVKDDITDRLVSIGNEFDYKMVFVVSDKTRAYYTYSGISR
YLDVENDSHDIWYKDYLDSGKRYTVNVDTDEDNNGSLSVFINYGIFDTNGDILGACGVGV
DMNDLVDILARFEEEYNIKVCLVNHDGLIQVDTDVSSIEKGYLDNSYFGNVSDDDFYYQL
SENGCYMTKYLEEFDGYIVIRDNNPVKLDVNKIILPIVLIFIASVLIMATSFVIISMREK
KAKDAYNRRYEASIKDELTGLYNRRGFEVDCEIIKKNNNLIEYVLIMMDLNGLKAANDNI
GHEAGDELIIGASKCMDNAFSGLGRTYRVGGDEFVALLRGTREEAQDAVKTFDYLTENFQ
GNLISELSVSKGVVVCSEHIELNFEEIKAMADKLMYADKDEYYRRTGKDRRRV
>A0A5M9IFE9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MFSVLKPHRWKLSLLLIAANLGLILHLACGELKSVSEWVWLDIFGEGGSALLALVWLGLV
LKSRPAGRVTNYLALGLSCIFFSWWIDSLDEFIRLPDSITWDHWLESGPMPVGMILLTIG
IYHWHREQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLADSLQDSREQQQPLSL
LALDLDNFAAINQAYGHAEGDAVLQALSHLLLLNLRRQDLVCRLAGDRFVVLLPNTGERQ
AKELALELQQAVRGLAHKTRQQGERLQLAATTAVVMALEEPPQDLLKRLNLALARAKQPL
AKSA
>A0A5M9IIB6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MDDTSDNGNFSHLNADMLHTVLELVSDGIWDWNANTGFVYRNPGWYEMLGYPRHSLENSV
FTWETVIHPEDYPHVMTLFDDYIHRRAPHYQIEYRCRKKDGSYLWIEDRGYVIARNPDGS
VARMVGAHRDIHIRKCSVEQLERRNQSLEALVAERTRELSRVNQQLQLQLDENRSLAERD
ALTLVANRYRLEKVLLEECDRAQRFRLPLALIAMDIDDFKPINDQHGHGVGDQTLLQVVE
CLESCLRPGDLLARWGGDEFIAVLPKSALETARELAEKICQKMRKIPMRGGLHVTLSVGV
AERRMDESPSALMARADQALYRAKAAGKDGVSA
>A0A3V2W361|diguanylate cyclase|EC 2.7.7.65|Salmonella hadar|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5I3IIS1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Coeln|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q1PY13|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MKNEIKVLLVEDNPGDVYLVREMLDDIQSVSFSLECAYRLSSALQKLENDFIDVILLDLS
LPDSQGLKTFCSIQAHASRTPIVVLSGLGDEEVAVEALKKGAQDYLIKGKIDGDSLARTM
RYSMERKQIELELQDGKQRYKRLVEILPDIIYRIDANGYFTFINEAVQVFGYEPDELIGK
HFSELIHPDDLKKVSRSEVLSEYSGKTSDYKTTPKLFDERRTGQRKTTGLQIRVKSKKSP
EYMEYTIQIIKWPKKHEKIIEVAATGHYDSDIMKNDKRFVGTVGVIRDITGSKHAEEMIC
TLSLAVEQSPAMIAVTDTDGRIDYINPKFCKVTGFEPEEVLGKNLIDIIQPGGESLSMAD
KTLWKAITSKGEWKEAFSSRKKHGELFWTSLSLSAIKSNEGFISHYLAIMEDITEHKQAE
ERIHYLAYYDSLTALPNRELFHDRLNMAIIHAHRKQQMLAVAFIDIDRFKKVNDTLGHST
GDRLLKIIADRLKSCIREEDTVSRQGGDEFVLLLTEISRMEDANDVTQRILKKLKEPVII
DDHDLCISASIGIALYPGDGTTAEALLKNADSAMYISKESGRDNYHFYSSTVQEKAYEQL
LEEMYLRRALENRELVLYYQPQVNIATGRLVGMEALLRWKHPKKGLISPAEFIPLAEDTG
QIVPIDFWVLHTACKQNMAWQRAGLPSVPIAVNISGHTFGRENLIDFVNNVLHDTRMSPD
ALDLEITEGIAIQNLQTTIYKLNKLKSLGIQITIDDFGTGFSSLSYLSKFPIQKLKIGMT
FIHNLHKDPTNSAIVKAVIAMAKSLQLTVIAEGVETDEQFEFLQGLQCDEFQGYLCSKAV
TSEEMGRFLAKNAGKLL
>A0A6I8L5V9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVVLAQLVLWDKRRADS
MPGPINALNLFCFCLFAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPALALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGISEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQALPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVDEQGMVARIGGEEFAVAAVVDSTQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISMGLETREVGHARITELFNQLLMAADEEMVKAKQTGRNRICMPALTESAP
>A0A0M6WC85|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MNYNDFLTRQQQIKKLSIAEQKNFYEQLLKKKYDKTEVRILASFYYGQLFYQEGNFRKTI
EIIEPIIVDYQSYPYTPKLLSCFNLIGVATHCETEYNVSRFFYETALKIAMENDEKYYYA
FEYNNIALTYIEEQNYEEALKSLALAEDVLKDCDEEMGAYIYINKSISLQKLNRLTEALK
AFELGVSQYHADTIVPDDVTRCAATLYYKLEQPEKYETYKKQILSKMDEMYAAEFMDACR
ELFECGRDSCDDNLMNHILRSMNQYMEKYPDEIKVGLEFAELIYVYAVGKMDKDAILEAL
EAKNYYKDRIIEYSKENHIKSLQQYIEINSQISELERDALTGFKTRKAYYKDIAIIECDE
EMCNQPVGIAFADVNGLKKINDNLGHEAGDELLAAIAKKIITIFQEAGCYRFGGDEFIIL
SFDKSETDFQNKLQKLSKLWTAECSASIGSVWLEHAKDIEKNLSVADEKMYVNKNHYYKN
RF
>A0A174ATB0|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MNRLFDTSVNVGLRQFYVLGAAGSIGNLFGFVGNVYIYGLSAPTIFCALCTLVIFGMTFW
GIRSRHVKRAAYVIITLITFFEFPILYYIYQTGTIVYMVLAMVAIATFLPTTAAVIFGCL
AFLVDMSAVILAYYHPVDVELVTAESELNSTVCSLMIVLFSVFTITIILNVQQKKQAEEL
TSLSRQLEQAADHDALTGLYNRRYLNRYLERLAQKGKKDVYAALIDLDFFKKVNDEYGHA
FGDEVLIEFARILERNLIADGIAVRFGGEEFMLILPDVTEEEIRHMLAKMSADYRLFGKQ
KKNRAFTFSCGVEQFADGMDVSDVYRQADEKLYLAKERGRDRVIINR
>D1NU68|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium gallicum DSM 20093 = LMG 11596|TrEMBL
MSKPIEATIVVVDDEPSIRELLVASLHFAGYEVETAGSGSEAIEVIERTQPDLIILDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVTRAGKPIDLSPTEYKLLCYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDDITVEDEDGTTHKVQPLIETKRGIGYMIRA
PKN
>A0A087AEA4|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium choerinum|TrEMBL
MVAHAQMPSAYTILVVEDEPTLATAIAQRLIAEGWRARIASDGISAVKAAAQLRPDLVVM
DVMLPGMDGIEATKHIVAQRPVPVLMLTARDAESDVIIGLGAGADDYMTKPFSMRELVAR
AKALLRRVERAKVIASKSEHEKILDFGSLVIDPATRRVTLDGETVHLTPTEFDLLTTLAR
KPKSVLTREQLLEEVWDWVDASGTRTVDSHVKALRHKLGAATIRTVHGVGYAFEPPEQ
>A0A4R0LJP1|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDGVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDHAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVANRLSEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSHEFNRPFDL
HNGHQASMTLSIGFALTWEHASAEKLQELADKNMYQAKNLRSERIIKK
>A0A376FDR9|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVSRWLFPVPVAQPIMHNGATIGE
IRLTARDSLIGHFIWMSFAVLTGCILFATVVALTITQSLHHGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMMEFGDKRHQ
AYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENA
SVEALLERADRNMYQVKNQRTKTTS
>A0A380A615|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGNLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A0A6TFC4|diguanylate cyclase|EC 2.7.7.65|Xanthomonas campestris pv. phaseoli|TrEMBL
MNQCDTVVSSASSEAQRLARLALLQVVDTAAEPFFDALAAAAQAIAGTPIALVSLVDEHR
QWWKANIGLPGVSETPRELAFCAYTIQGDAVMEVRDAPADPRFHDNALVTDAPGIRYYAG
APIVLPDGLRMGTVCVIDQRPRALEPAQLQALQQLARVAAEGLEQRRVMLERETANAQLQ
QRLRESEAFLERTGRVAGVGGWEVDVASGTLIWSDQTCRLHDVPPGYRPSLTEAIGFYPL
EARAVITEAVDACVRDGTSWDLELPLTSATGRRLWVHSTGSVEHVDGRKRLIGAVQDVTD
RHRAVDALAASERKFRKMFQYSLGLICTHDMHGRLVSINPAAARSLGRSVEQMEGRSLVE
FVRPERHAALRGYLSRMVLDGQDSGVIELVAGDGSLRHWQYHNVLDVESDATVVLAHAQD
ITNQYRQEKQLLEWSFTDPLTNCYNRRFLDELDKRDPSVRWGCIVVDLDKFKLVNDTHGH
QRGDEVLVQMAWFLNQPLRTQDRLVRLGGDEFLVLLHQATQAQLDALKRDYVGAIDDAPI
RFTLGTALRQDGEALAAVVDRADHSLYSLRRARRGTGTSDQR
>A0A222LZJ4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A3Z3G8G9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Java|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A344R548|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3U5QN46|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A3Y6LX92|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5J1DCM2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kedougou|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2T6XAY6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3U9QQ44|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V4QZQ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3A3KGA1|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5X9ZQC8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Johannesburg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A658ZWU2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGHALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A2X3CB49|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLVIVAVAVGCALVSPPVGTRHEILTNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKVIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHAL
AQAILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
SAGAAG
>A0A336QYM8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MTVQSWRTLRTKKYQLSLRLFLLLNAVSALFTLFFPLFAVKALPVPALLILVMSTLLLAW
HRKYVDKRISLPFISIVFGLLWALHIFLKYNALGHNDYYFLLIALLSVLFIGSIAFANNI
IAFTLHSLPSVAVCLWLNGSEQGLRIFYFMALPMAGIAIQHVIQKRYDGFAQQLMYKLLE
ERETLNGLSMLDPLTGLYNRRGLQHRLDTLLALSNAKHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDSVRSRDVVARFGGEEFMVLLTAVDPQQAQAAAERIRQKVYDLKIPHM
FNESVATNVTVSIGIAPLVEQDIDAAVARADKALYEAKSLGRNSTLVSDDLR
>A0A483IK96|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMG
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A486QNL3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A826YXR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGSLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRNVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHEHNNATEPQVTV
SVPVDNNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPDHPGED
LFDPRELASLAQDIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRMYNRGALFEKARPLA
KLCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEE
FCVILPGANLEQAKEVAERIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>C3THC2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A3Z9B216|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTLREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRILSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2S8JMI4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTSLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A244BEV0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LVDWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQATAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRRFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAENVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0A1A4R6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENTDISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A4Q8KU58|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGALVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTINSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQTAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSCATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A0D0N535|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A719DN43|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain SL1344)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPRAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A839B1Z5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTINSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSTLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A3K0W8E0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQICGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A094VN24|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYLTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A0L6Y354|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFMSCLIYFVKTVIIIQQMIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVLGGPIVAHILSSHYESYDLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPIGDQVIKTVVNIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQGNALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A619ENA6|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHWE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0R9PUP0|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A788XWH2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A447KHZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLGISSTVLVSLLFGLAFVLVNSWFNQPTVEEVVPRSTYLTVMIALFFIDTVVFIF
MQLYFIYDRTRFSNCILSLAFLSCLIYFVKTVIIIQQFIEGHLTSSNVQNDIAIYYFFRQ
MSLCMLIFLALVNKVSENNKQRSFFSKKMTFCISLIFILGGVVVAHMLSSHYENYSLHIA
ELTNKNGRVVWKTSYVTIIISMWLTLLLVNLYFNGLRCDIWNGVSVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVISKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
KAQSASAQKTSYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPNDLLARVGG
EEFGVLLTETDTESAKVLAERIRANVEHLTGDNPEYAIPLKVTISIGAVVTQGNALNPNE
IYRMADNALYEAKETGRNKIVVKEAEIVINCKDDD
>A0A4U9TJV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRMFQEGHLLRNSIAIFVLTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLLAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEVVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A2S1JBB2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MRNNSIVSRYNRKAVLFSMLFFVFMSIMGCGFFSFFIKSHVQGLKSSVFNSGLFVANMAE
YRRSVAVKIMSQWKGLTLTELLSAFKQAYVDLPPPSYVYDIGPFILNNDLCFSMKDNDKN
YCDGILNSALYLERRNDGIILLDGVKYIYFVQPLRDNIQLVFLVDATHYVTLVKKQYPFG
IFLSMDVFTQGRSIYSDDIGQSLVFPVTAFTSGLNYLPELTYVFGFSKRIFLLVCSVIII
LAAVISCVIYKTYFSLIYGIYDQGLKETRAITENQLSFVVSGGLFFNDADIRKLHDIFYA
AIYDSLTGAYSRKSFDDSIKDIIGTGDSYLCFFDVDRFKFVNDNFGHLFGDEVLIYVVHY
LKDKMNGFNFRIYRFGGDEFAIIYSGELCDLIRILKGLTDFEVGGLRCSCSFGVAAEKEC
TTAEALKLLADNRLYFSKNNGRSQITWK
>A0A1C1ED22|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHINCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A2A5MEU7|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNKDFSQTSRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQPFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQLIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIGLLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A2N4VHN2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIQAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAAAAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A8F9HH87|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MNKDFSQAPRPTFKRALRRISVISVVISMTLVWLLLSTASVFTLKQYAQKNLALTAATMS
RSLEAALVFDDSAAAEETLATLGRQGQFSEALVLDNQQNHFAVWRNTDLVRQEKFSGLIS
KWLFPEPTTQPILHLGKVVGELRLTALDSLISHFLGISIIVLTGSILLASFIALLLTHSL
HHGIVTALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRTSLHDPLTGLANRAAFRNVISTLMKDEAARRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMNFVSKRHQAWRLGGDEFAILLRDVHSEAEVKTLCTSLSSQFLEPFNL
HNGHTATLSLSIGYALAWEHASAENLQEFADQHMYRMKHRRIPQVQK
>A0A483KFZ7|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVTPLFTVVRFTLPCALIVACSGLLLLW
HWKWPQSKINIPAISLLFGMLWAWHVVTKAMLLTPPHFNFLVIALLSILFIGTIAFSNNI
TAFTLHSLPTFLACLIMAEGEQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMQ
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHFVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARFGGEEFMVLLTNSSEETAWQAAERIRQRVYDLKIPHM
FNESVATNVTISIGLTPLIDDNIEQALARADGALYDAKNKGRNIILAS
>B0NGP7|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain ATCC 35704 / DSM 5676 / VPI 13733 / 19)|TrEMBL
MQDSGYFQKMTEGLIHTYYLDQDWNAALSYFDRNQVSWIGVSDQAMALDYDKLKVFFEKG
CNSKYEIRLLNENYSMVSKGEDFAVVIAQFLINSRVDKNGFFSLRQRASFIFHLCGGQWK
VTHMHVSAPNSIVKEKEYYPEEMSVENYRLLKRLLIEKTQQMEILAQTTAGGMKGSLDDE
DYTFFYVNDELCNMLGYTYDEFMEMSGGTAKGAIYPPDVPKAMRDCRECFKKGDEYKTEY
RIRKRDGTLLWVMDYGKKVRDANQEVIINSILTDISEIKETIGQLEMEKERNEIVSELSD
DIIFDYNMREDELQVFYPASIAGEKHKKIIKTARVSDGWKELGVSPEDEAEIYKKIMDIS
NDKISNKTIKAEYRIVDWNAKNIWRRVLMRGVFDSEGNLAKVVGKVVDISSEKELMLRSN
TDFLTSAYNRSYLELAVKKAIRNKGVDLYYACLLIDIDFFKEINDKFGHLQGDCVLIEVV
KMCRALFRSTDIIARLGGDEFMIFMRDIYDQKIVLEKARKMLDMAENYSIRDDIPDRLSL
SIGIVIDDDIAKNFQRLYHQADIALYQAKQNGRGRYMVFEEGMMHPSD
>D4MZ20|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MDMDNLKTINDIYGHKAGDRVLKLLGNLLLEYSSECLVCRLGGDEFLLFMPNADQNSITE
VITAIFKKFNTRKEQDPELHAASISAGLYMCNIGDSFDECYTKADKTLYFVKQNGKSDFS
FHEK
>A0A1R2MWY9|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5U5E4N4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3Z1VAT9|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1S9JVT5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A443VMC2|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MFQKKPFLLSLLIALYSGGVILTTFLLLGGIYFFQKKEIEDSLLESNLAYAMKIADTTDR
YLAMAQRELAWTASELHSTDASVARYEVERLRLRSAVFNSVGVVDAKAAIIATSPYLPAL
TGVRVHSAASQNALAVQKPLISGPFTSIAGNDMIMLSHPLRSPDGHYLGYLGGSIYLKKQ
SMLSDIISLHFYKDNVSVTIVDRDGKVIFNTAPTMTRSPVNLTPQLKTYMSNNLNGSFAG
RDYLVGYAGLKKSNWNIIVSTPSEVVTSMLFNTVKKISGLVLAILFFITTGVAFLSSRIA
KPLEQLARLVQTNDSLTSPEKLSSIRAWYQEAYLLREAMEKRFRLVSAQFAALSDEAMTD
PLTGLYNRRGFYEQLTYIKNLKNQCAIAVDIDHFKAINDRFGHSTGDDVLVHTADLLRLT
CRKEDVISRFGGEEFVILLTETTLAGSAAIAERIRQVISATEFSEAGHLTVSIGVAGLKD
YEGDYERLLMAADSALYQAKRQGRNRVVVSGHSQ
>A0A2S8D4C2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A750SE71|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPMAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A758BI34|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLIGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDIGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A708D1Z8|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNEENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5U2V2I7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A486X2E5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MFPKIMNEENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5U4PUN2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V7VUT6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A626B1P0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Poona|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3U5J7T1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8B4RWE6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter junii|TrEMBL
MPSLKVASKSLSLSQLFLLFSAVILFCCLLGIATRQLTFLASFWPANSVLLGILIRFPQT
RHPISFIGAIAGYLIADSMQDTPFLLNVCLTSANLLYVITTLALYIRFRNYIRSLHQGYF
YLFLFSFCCIGALSSSLFAAISLPYFNTKFALGTFWIDFGYWFTAEIQNALLLLPALLSA
PNFKELKQQFIEFKTQTVQQSFPLFAVLISIVIAYYDTGPGSLLYPIAPLIWCALAYRHF
SVVIITSITCAFIIHHVSENYLQLYPHEYLNNTISIRFGLIMMTIAPLTVSNINMVRSKL
IQELQHIVAHDELTSSLTRRQFLQSVQLLHAQAQKAQQTTAFLMLDLDHFKKVNDTYGHQ
MGDKALKYCVQEIHSLLRPNDLLGRLGGEEFAIFMSDIDPDTAFQYAENIRLNISKMPIP
LNDQQQFYIQVSIGICLCTPENQQSIDALFKQADDALYQAKHQGRNQVVIST
>A0A8G1HVL5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mandelii|TrEMBL
MIDYDQQVLARAWDAATNPVLITERTGCIVWINNAFCRLSGYSKPELVGKTPHLLSSGRQ
SSTFYRDLWLTILAGLPWQGEMVERRKDGASCTVNQIITPVLDPHGVVTHFIAILHNFKV
TDEERANMQQLAFHDALTGLPNRSLFLNLLNQAINHATKHQQPLALMFIDLDHFKSVNDT
LGHACGDKLLVAVAERLGQSVRRSDVVARLSGDEFAILITCMEQADQLEALANKLIAAIG
EPFMIDAHRVNTAISVGISLFPANGASVEDLLEQADGAMYLAKRAGGNACRFKRLSPDD
>G4SZ12|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MDTLPPLIQAHMTEIYLVYGMAFLFLAAAIYLQPKDNSVLPFSTILVWLARFGMLHGIRE
LQCAWELIDGSLNEKNSLVGNLLSFASFYALFEFSRRFWLVLACNSENNRRRLKYIRLFP
VVSLLIAGITAALSQNYAAIFDSGIRYLLGFPGAASAGIAFLVYEYRNRPYLSTLKLNFA
MLLAGYSLAFYSLFTGLVVNAPWFATPSLADARIFSETTGIPIEALRTLCALALATATGI
MLYRVNVEKHRREFQASAQLADLNARLETTIAARTAQLERANEKLQQEVEERRHIEESLR
QSQENLNRAQSVAHIGSWYLNQADNGLEWSPETYRIFGVPPGMPLTYEEFLERVHEEDRA
FVDRAWQTALKGAEYNIEHRALIDGKVKWLRERAELEFDRQRKMIGAVGTVQDITELKQA
ELALQQSFEDLSRAEQKQRELRIVAEAEQGRMAALLSAMSIGILFEDKAGSIEYVNLAFR
RMWAIEDDLDPVGQSTQFVLENSTHRFARPDHASKYVLKVLDTHEISERFELDLYDGRIL
TQVSYPVTDTEGRILGRLWIYEDITHERQTAQQLLYLAEHDALTGLYNRHRFQEQLDHMI
AMARRNHDKFALIYFDLDEFKYINDNFGHRAGDTVLVRIAGEISVVLREVEIFARLGGDE
FAILSYLHPQNDISVLPNRINQAVASIPFRFRGTNIRLTTSVGLAFFPEHGETVEDLVAH
ADTAMYQAKANGKNTWAVYDPKRDDSGAAMERMSWRQRIEQALRQDLLELHFQGIYRVDN
GQLCHFEVLVRMRDPQHPEQLVMPGQFIPIAENSGQILEIDRWVLRSSIALLSENSILPS
LAVNISGRSFDDPELPQFIRACLEENRVDANRLIIELTETAAVSDIRDAQRFIEGIRQAG
CTVCLDDFGSGFSTFAYLKYLEVDILKIDGMFIRDLPNNRENQIFVKAMVGIAKGMHKTV
LAEFVEDAATLQMLKELGIDLAQGYHLGRPSADYGKFIENRAT
>A0A377QCW3|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MSARMSNKPARQPRRTLDSVLRRAHLSVSLIAVLAAGLTLTAVALLALRVYSDQNLRLVA
RSMSYTVEGAVVFGDSMAAREALALIGVNEDIDQAQVSDQDGKVLARWERGEHGTRYYIE
RALTGWMLPDSLTFPIMRNDQAIGSIKLVPHSRSLLPFLLSGLSCLLACLVLSLVVAVRL
SRSMETEITSPLRHLAETAHRVRRDRSFELRVPPANIAELNQINDDFNALLDELEAWQSH
LQKEHASLSHRANHDSLTGLSNRAFMEAELERAILDARVGNGKVAVLFLDSDRFKYINDT
FGHASGDRVLVTIAARIKQQLREGDLVARLGGDEFAIVLKPLRNSSDAMHIADNIIAAMA
QAIELPTGNSIVSSLTIGVAVFPDHAIDAISLVGAADEAMYRAKQAQRGTRQVARLPQPH
IHP
>A0A5M9I9P7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MNGLGHGRDQDCFIEAQVRTDRLHQLFRQSFAAIFGSYMAAAMLCWLCWERFDHTLMLVW
LVVLGASSLLRVKMFLDWFRCPNSERTPDRWERRYWVTLVLSAGIWGAGALALMPPDDRL
SQALVMLFTVGMSVSAVSCYSAYRYMTLVSIGLVLLPCTLWLLFQPTSMQVGIGIAVLVF
STFVASATRKLSDALEKAFRLTRQMERAHNISTRAAQTDELTGLMNRRAFFEHAQLLYAQ
CRHNQQPLCVLMMDMDHFKQINDTYGHQAGDQVLRQIGGVISASFRKADVYGRLGGEEFA
VLLPNTSLDTARTIAEDLIKAIAGLAAEPVKGLSASLGVAFTHAVDEDLHGLMNSADKAL
YRAKALGRNQVAVAE
>A0A853SBK4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MSSKLPSSPASAPAGATSTAAAAAMNPADIAREAFRRLATRRIAPTPSAYRDIYNEIAGI
SEPADSPAAPGAVLAASANVEKGAESGAENVLTQFAAKMSESAGELGDFGRRFQRALKAR
DWDSYARTLAQLAEKQVKKGGGIELPPLPDGEQTRTLRELLSRTLGFAVATLLTGTPALV
EEAESLGAAIKLAHTEEALNEAALRLKQLCYQIELKSGDTAEQQELLLRLFKLLLDNVSQ
LLDDDSWLRGQVDAVQNLIAGPLDQRALEDATRSLKEVIYKQGQLKHSLSDVKLTVKNMM
MTFIDRLGQVAASTGDFHEKIGGYSEKISQAENISELNSVLDEVLRETRMVQNEALRARD
KMVLARQEVQDAEQRIHTLEAKLQHMSELVREDQLTGSLNRRGLDDVFERETARSDRRGT
PLCIAMLDLDDFKRLNDTYGHLAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILLPET
TVEAASSTMTRLQRELTRHFFLHDNEKVLITFSAGVALRLPNEDQAELVKRADRAMYQAK
QTGKNRVVVAD
>A0A1C5TEM1|diguanylate cyclase|EC 2.7.7.65|uncultured Roseburia sp|TrEMBL
MRIQKRKIILPVMVLLLGMTALGAVLYGVGNIQQNNSRKMANLNAMVYSERVKSDIMQEV
GVTKALKQLLVSENGRINKFSEVAEDMMMDSIQSIQLAPDGVVTEVYPEEGNEAGKIDLF
NDADRGEISRYARDNHIEIMQGPFQLEQGGYGMAVRNPIYLKNENGEEEFWGFTIVIIRV
PDVFFDSLKALSDFDYDYTLSKTVSPWDTTYEEVCSSGAILTDPVAYEFEAVGSRWKLEI
MPKAGWSNYEHFYGLLAGGLLIVLLLTGLVSMILALDEHKNRFKKLAVTDVLTRINNRHG
FEEQVRQYLKKYPEASCVAAQFDIDDFKFINDIYGHESGDRALQILAESMRKSFPEHAVL
GRKGGDEFCIFLDNCTGEEVGEKLEQFTKKKCSFWYEGEKVTYTISLGYAEYPLQGQNYS
RLMRCADAALYEVKLDGKNGCLQYREGIGLEIRKQLGFALKDVSENLPGAFIIYKADKEN
DEILFANREMIRLTGCRNMTELQEYTKGSFRNLIEEGEREQVEESIWKQIGGGHSNDYVH
FHLRKADGTSLRVLDHGRIVENGRYGRVFYVLMVDWNSTKRHYRDVF
>A0A7V7REV1|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MRSGIAPDGNAYADYVVMIKKKNKQELAATPHPLLRLVSLGLLTYIFTLFSLELTLFDTL
LAPLWFPTSIMMVAFFRHALRLWVPIALVCGAGTVLATLTLFPPGHLELSYTAINIVEAL
VGAILLRKLLPWYNPLKNLNNWLRLAFASAVVPPLVGGLLLAAISEGHVTLRLALVWILS
ETIGALALVPLGLLFKARYLLRHRSPRLLAESLATLCVTLLCSWLALHYMPWPFTFVIVL
LMWSAIRLPRLEAFTVFLATVMMVSFVIATNPALLDLPHQGMVVNAPWLPFLMILLPANV
MTMVMYASREERKLITESETRFRNAMEYSAIGMALVSTEGGFLQVNKALCNFLGYTPEQL
AHMSFQQLTYPEDLHADMEQVEKLLNGETNNYSLEKRYYTRAGDVVWALLAVSIVRQRDG
SPLYFIAQVEDITELKRTEWVNKRLMERITLANEAGGIGIWEWELGTDVLAWDQRMFELY
EVPPHTRPTYQLWKSRLLKEDVAHAEATIQEALRARMPFKLEFRIQVKNGVRHIRALANR
VLNKQGEVERLLGVNMDMTEVKQLNEALFQEKERLHITLDSIGEAVICTDIDMNVTFMNP
VAEKMSGWRQEEAIGQSILTILRITFGDNGPLLDDIHNGEATHAGTGIEQDVVLHCRSGG
NYDIHYTITPLSTLEGENIGSVLVIHDVTESRKMLRQLSYSASHDALTHLANRVSFETHL
KRLLQSVSDTHQRHALVYIDLDRFKAVNDSAGHAAGDALLRELASLMLGMLRTTDVLARL
GGDEFGLLLPDCSLENARTICERIVAAINEYPFVWESRLHRIGASAGITIIDASNNQAQD
VMSQADIACYTSKNAGRGVVTVYEPHQQQLHSGRGTLTPQEQQRMINEHHHVLMVRPVAS
PRVPESASFWLLSLRLWTSEGEMIEEHSFRAGLNDPELMQALDTRMMTDFFRDHAASVAQ
KGVGVALTLSGATLLNAQRLDALLAQLAASPLPPRLLHLVIDSDVLMQDATQARRQLARL
REAGCRVVLSHIGRELEVFEHLSASCADYIMVASDLVADAHASLMDEMLLTIVMGNARRL
GLQTIAGPADQQSLLETLANVGIDLVFGETVAQTQALSARLATSYFAIH
>A0A381H328|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MNIHFAVIWGIFSLILLGGRFMLIRWFDEAWRQNQHNNLLISRLDNLAHRDPLTGTANRR
AMEKLLHSATAQQNAFALIMLDVDFFKRYNDAYGHPAGDACLSQVADIFAQSVRSPEDVV
ARYGGEEFAVILFDATLQDAERVAARIQKALEAAAIPHPASTISDTVTVSQGIACSEKGK
TAEQTIADADAALYRAKEAGRNRWGR
>A0A0X8HD78|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MIPAPRWRRHLGWLWLSLMSFTLLMLLIAYQTRWVYPEIHAYFSQAGNLTGQQLATRSRD
YLQESLDILLASPVDDDGRDRAHFHLELAYSLFDIGLYRNEYSCTRPSLAALDELKVKLR
SGESLLPGDLRHSLLSPIRCLTEIEMHQLDRRSSVTAAFVEDTRRHQGQVLIGSVVIFVL
GLAFWWMHERHRRSAERATRESLEWMARALSDPLTGVGNRSALHQDVLASKGQPMGLILI
DIDFFKQYNDHLGHPDGDKLLRHLAHLIDETLGRQARLYRMGGDEFAALIDCVDDDVLAG
HCERLVKELREAALEHPAHPGSPTVTFSVGAACFIAGQAGFDAGYAAADQALYRVKAGGR
DGWQVAEAKVVADSGDLKLERS
>A0A2X2WM53|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MDKDFFPTTRPTFKRTLRRINMISVLVTMLLIWLLLCVASVLTLKQYAQKNLDLTAATMT
HSLEAALVFSDGRRRDRNAGRAGGARGSSRPQRFAIKTRR
>A0A8G2RY66|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRALWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEATFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAALVSAFGLGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RQGLSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFRVNEALCRMLGYSAERLGELSFQEITYADDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGIAQYFVTQVEDIDSRKRAEL
ERERLAERVKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKATLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNQEVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELKRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTSTSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDAIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRGGLRRQELG
>A0A8F9NL04|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPGDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHIQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>E6BQR1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 85-1|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYITKRRGRNRVELWKASL
>A0A8G3YJC6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGEPFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>T0PA86|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MGKRVVSKKTWSLVARMRLGLLLLFIPVLMLGGIYYLHMERSLQNELQQRLLATNHQLRH
VFIEPYLHEMERQFTLIYDQVKVDDISGPRLHNTESYLKAWQLYKGVMADLIYIYVGTAE
RQMLIYPEWQADAQFDPRVRPWYQLASQHVGEMVWTEPYYDYINGNLVIALARALTDQSG
KVQGVFAVDAILAPFSAQLNRQADNGYQMIVNQSGKVLVHPDPARLLKPMDHPQWLSRFK
REDGIFLDKDAQLFVAYSKLPERNWVLISVQPAASVQAVVDRVSLNVLLMVALACVLYVM
LALVWSRYFHRMLNEISSMIRASRTQPDDVPQGGMQELKHVYAELAEAGKDYHEARQQAN
LDKLTGLYNRRFFDERLNRLLIERQPFCLAMLDLDNFKLVNDTYGHQTGDIVLKRVSQLG
MQLLGDHGWVCRYGGEELVVLMANPDIHFCQMLLEQFRKGVESLDWREPGLKITFSGGLV
ASGEIAHGKTLLAVADAEVYHAKRDGKNRIYLGSLHETVAEKGSPPNDSVLSNEEA
>T0QVX8|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLRGKFLSLILMVTTFLGVAIWSVWNYDRAFNAVTRYTQLSAWALAQLELEIHAFDEALL
LYRAGAVSQEEMNKRFDIAWNRLDVFLHGEEARSVRERFGAGKAAGKIMTLFEQYEQDVM
SGGHDSSPLAHFSDELNRDLVAIRDVMVKNFTGPSAIAQRELLNDSRTQNFAILAFLMLA
TMVMLLVLFREVRHQHFLAWNDTMTGLPNRAALIKHLKHLKQRAAHRGGGRSITVCVVDL
GHFREVNDSLGYEIGDALLKQLAERIHDALTAGIFVARTGSDEFAIVISGVMPTYLRFPF
LEQLRSELAELAFAADPAHRVRVFMGVSQYARPVNTPEEMLLFADIALDSAKRRRLHRYV
VFSSSMYEHYLRNRRLSAELRALICCIDCQQLSLYYQPIVRGQGAVRLGAEALIRWRHPE
YGFIPPLDIISLAEENGLGEDLGVWIFMRLQHDLAIFPSDLIEPLEISVNLSSSMFNMGL
AANVEAKTSEGPLGLQQLIVELTETIALDDIEMSKQIIHSLRQIGVRVALDDFGTGWSSF
SYLRELYFDKLKIDRSFITAIDSDTRQALFVEAITTLSHQLGVRVVAEGVENSNELNAVL
NIGVDEIQGYFYSKPLPLQDFLLFCHRYFINRAIMQEVVLG
>A0A5S9PL87|diguanylate cyclase|EC 2.7.7.65|BD1-7 clade bacterium|TrEMBL
MRTFIDRLIARGLALLVPSLLLISSYVALSYIDLLAEQWQVLVLQAGPILGLLLASALSI
QFSRTGYFFALLFVIVASIASDAGLGVVIPYQTPIYVVLFINLLIFSGLEDRGLFSVHGI
LRLAVLGAETVLGVYFVEHQQQFIDYFIALHPSVVALNSLTYSLGGLPWLIGVSVVAVCI
QLLCLLFSSRVNQPIFLIAQVVLLLMISGVQSELWVPLLLIAFSTAVCFNVLRQSHDMAY
RDELTALPSRRALNQLLLRVGRRYTVAMMDIDHFKKFNDTHGHDIGDEVLRMVASKIARV
GGGGKPHRYGGEEFTIVFSGKSPAQVEFHLEALRETIANYSMVVRSKRTKENTKKTKSDA
KKGRRPNKDMSQYKTLSVTVSIGVAERTGTLKTTTQVVKAADEALYRAKKAGRNCLQY
>A0A157LF93|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MYVDLLTLYLLATGTLAVSAGLLFWEHRANPKRATTLKRLAVGFGTLALGCVAVLYRGSL
PSPLGSAIGNLIILSGYLLVLAGVGSFSGQRYRAFSAFILIGAAIMWTIAGAEGEAAGWS
YYSAVPIALVSGMTAWAMWRCQAMKAFPARHIVVAAAGIHTLLYAGRATLLPWFVAHGGP
AVQAIASKLTIYEGVLYSVALPMALLKVIRDETHGQLLQESLTDYLTRLGNRRWFFEEGP
RRLHACAGRGPIALLAFDLDQFKAINDAYGHSTGDRVLKTFAEVARDVLGPQTLLARIGG
EEFAALLVGDDARRARQLGETIARRLPETIAQRIDGLAIATTVSIGMSCHQENLPTLPEG
LSAADQALYRAKSLGGNRLEEAA
>A0A2X4Y7W5|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MTAQSWRSHYEQKYQYSLRLFLLLNLVSSFLSLVSPLFTVITFTPPCFLIVACSAVLLLW
HWKFAQHKINIPLISLIFGLLWAWHVALKAMVMGPPHFNYLVIALLSVLFIGTIAFSSNI
IAFTLHSLPTYVTCLFLGGGEQWLRMSWCFVLPIAGIALQSLMQKRSDVFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTILSLDSSEHYVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTSSSAENALQAAERIRQRVYDLKIPHM
FNESVATNVTISIGMTPLVDADIDSALKRADNALYEAKNMGAKHYSRQLTPVSRSRVSSG
GQIACQAGAPALTSEIIII
>A0A146AYL4|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPVLTSKAWTNFVRGSYPSRALAQGLTFLAVAPILHQLDAPWWQWLLYALHAFVWPYAAW
RLSARAGQPTQANRRNLLIDHFAAGWWAAGIAFNALLSIVMLALLLMDSMIAGGWRQFLR
GAGLHLAGVVTGLLVFGIDWQPIPTPEQVWACLPLLLIYPAMTGRIAYLALHELREQRED
LSQLSLHDALSGLHNRRHMDAVIQSEFQRYRRHAEPAALVLIDFDHFKRINDDLGHPVGD
KAIRQFAKRLQLSLRSSDTPGRYGGEEFVVLMPHTSARNAGLFMRRLQQSIRDEPLIEER
PVTISIGISALSPELESHGAWVKQADAMLYRAKGQGRNCVVIAGDDAPEPQPAEPPRGAS
QQLLPLERRLMVGLELGNIAAAIFDPSDRMAWANEAFRRLYCVPPKARTFADIIHHCHRL
RCGPRIETQSLRTWLSIADTERRRQPHRSFLQSMHDGNVYRVEETLMANGWLLNLWLPHH
REGAPSEELQAVAGGVDPLVPDRQQVGQALHE
>A0A0D6JB47|diguanylate cyclase|EC 2.7.7.65|Candidatus Filomicrobium marinum|TrEMBL
MTARVLVVDDIATNVKLLEARLSAEYFEVLTATSGQEALDLCERERIDVILLDVMMPGLD
GFEVCRRLKTDPKTHHIPVVMVTALDQPSDRLIGLECGADDFLTKPVDDIALITRVKNLA
RLKTLNDEMMMRVTTGRRLGATEHAALQRVLSNDGGRILLVEDHERSGHRMTEALQPLHE
VTTERFPQSALLRLGAEDFDVVVVSLSLQGSDGLRLCSQLRSFERTRHVPIIILLEDGGD
ARLLRGLDMGVNDYLMRPVEEHELLARVMTQIKRKRHSDFLRDQIEESFELAVTDGLTGL
HNRRYMEIHLATLVCDAVRTGRELSVLITDIDHFKAVNDTYGHDVGDFVLKSVAERLRRN
TRGADLACRMGGEEFLLIMPDTPLSGAYQIGERIRTRIASEAFQTPQGTRIRVTSSVGIA
TLEGENDTPESILKRADNALYAAKRRGRNRIASTAA
>A0A446CUH4|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MIGRPGGTPSGKHKIGLLAVLTVLAILGVSVGFINALYSGYQVQKAQVIANSLASNRVYA
EKLAEVINVYIGALHRQLQAGAPHLAAQRDDPRALRGELQRLASQADAVVSVWLADADGR
IIASTADAAPQAGDARRLADLGVRELRVGQWVAQRPGDGGAALVLVEPVARRQGEPSGYV
AMMIALDDGSGIDRVISGQAPADGTSVFLVSNAGQVLYRRQATRSALVLATLAPIREAGA
APLEDAQGDTVLIGYSPLEKGNWAIVTQRSLDQVLSPLRALLAESLRFAVPAFLLTLLLV
CALAYAIASPLSRLSRAMAAGTDAGQDLNRLNAWYAEADTLREAVKTTLAQHRREVGRLN
RETQTDPMTGLMNRRALDEALAEYAEKQSPFAVIALDLDHFKRINDTFGHAVGDEVLIAL
AKAMRDGLRGKDRPFRIGGEEFIALLPTASAGQAAEVAERLRAAVAGQRMPDGVGQVTVS
IGVALWPQDDTSHQTVIQLADQALYASKQAGRNRVTLWRALGSRARDS
>A0A1E3GTJ2|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MVHLLHSDTTNLRRLEQNTVSVIQAGPISAERDDALAKLPLILQTSLDTRQLLRLFDEQI
KPLLAHNGLQFTHPDNKFEFRLGNNRHHKCNYQLEIDQEYLGQLTFSRAYRFSDNEIRLL
EDLLCKLIYPLRNSLQYARALDAALTDTLTQLPNRQAYKNTIEREIDLAHRLRLPLSLLV
LDIDYFKNINDSFGHQVGDETLCRVADTLLASLRRSDALFRIGGEEFAIVLSHSHHEAAL
LAAERLRTAIYELNQSNTDQKFPISISIGLAELCVGESADSLFLKADEALYQAKFAGRNQ
VVTSRVTA
>A0A7G6K4X5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFFDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A8E2TCE5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEAAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8E6X0A0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>I4SHL3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 541-15|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1S9IXJ7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLNEHDIIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINHANNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKMNRPG
>A0A8H9DZU5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MNVERRGSVGQSASQPNCKQEEAAGEQTKPFQVSKLHVVEAYRRVKANAGAAGVDNQTLK
DFERDLKGNLYKIWNRLSSGSWMPPPVRAVEIPKKDGSKRLLGIPTVSDRIAQMTVLVTF
EPLVERYFLNDSYGYRHGKSALDAIAVTRKRCWQYDWYLEFDIKGLFDNIPHDLLLRAVD
KHCADKWVRLSIRRWLTAPVQMPDGTLKERNKGTPQGGVISPVLANLFLHNVFDKWLSLH
YPEIPWCRYADDGLIHCGSKQQAEELLNKLAKPFQECGLELHPEKTKIVYCKDSERQANH
ETVQFNFLGYTFRARRARNQRRGNLFTSFSLAVSNSAQKDMIGKLRKLRLRRRVEMSLED
IAKRLNPMISGWLNYYAKYYKSAMKKVCRYINLTLIAWARKKYKTLRYKKTKACQLMERL
SKEKPELFAHWKAGPGSAFA
>A0A2P9H5P2|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MGAPLRAAATTCPEASDALGGESALPVENPSQATDREQAPVERARQVRNKVMERLSKGAA
LEEILDLLVREMEFDHAGTLASILLLDETGRYLHVAAAPNLPGEYRQAMEGIAIGPNAGS
CGTAAFRDERVIVSDIATDPLWAGCRDFALRHGLRACWSEPIHCSGGGVLGTFAVYYRSI
RAPEEVELRTIVDAANLASIAIERKRAEERIARLTNLSRARSEISQFIVRTTDEDELLSA
VCRVAVEFGGMRMAWIGRANETAKRIEPVARYGEGLAYLDGLTIATSADVPEGRGPTGRT
FRNGDCVIVNNFETNASTAPWRARAQEHEFRSAACFAIHHAERLFAVLSVYSNRTGSFDS
DAIGLLREITKDVGFALDGLDKARERKAALEALSRSEQHFRAYFERSMVGMAATNSNRRW
IEVNDALCAMLGYTREELLSRTWAELTHPDDLTVNEKNWERVRNGDTDEYETDKRYLHKD
GHPVDTHVAARVVRTATGEIDYIVALIEDITERKRAERALREKNEFLNSILQSEPECVMV
VGLDGQLLQMNHAGLRMLGARDVDEAQRSGLLSFVLAKYRRAFLELHATVCKGGNGVLQF
EVRGNDGVVRWLETHATPLRESSGAVSALLGITRDISEKKRSEELIWRQANFDILTGLPN
RYMFQDRLAQEVKKARRAGTMLALLFIDLDYFKEVNDTLGHETGDALLVEVAQRITSCVR
ESDTVARLGGDEFTVILPQLSDPGSAEVAAQSIIARLGEVFNVRSEAIFLSASIGITYFP
SDAGTVDDLLKNADQAMYVAKRQGRNRIGYFTVTLQAAAQNRLRLINDLRGALVADQFRV
YFQPVIDLATRQICGAEALLRWLHPTRGIVAPGEFITLAEETGLIIGIGDWVFREAARWA
KRWSEKVAGNFRVGVNNSPIQFRDGTNILSWLDYLRAIDLPGKNMSVEITEGLLLDADAG
ITDVLRRLHEDGIGVAIDDFGTGYSSLSYLHKFQIDCLKIDQSFTRNLQAERSAKALSES
IIAMAHKLGLTVVAEGVETAEQLEFLVAAGCDFAQGYLFSHPVPPEEFDALLQGGLSTLR
ELPDVDW
>A0A398Q9T8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDNSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINMLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8H9AF66|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDSFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTDPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>G0EXE9|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MTPDTAPPSHQAAPGPSAPQRRWLPLLLAGAGYFVLAAAALWLARLPGTVEAVWLPNAFG
LGLLLHRPRAEGPWLLAGMMGASVLANYAAGDSVATALMLTGANLAEMLFALGLLRLLDR
HAVLGRHGPLAAFAVMLAVGGILAPALGATAGAMAIATTHGTSFASVWWTWWQADALGVA
LLLPMMLSMTAVRVRAAIARPLLAPQAGALALCLAIGAFAQWQGHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLCLQALMLLAHRHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
SSDKRFRQAMEHSAIGMALVSMDGRWQTVNRAMTELLGYGAAELRELSYQQLTHPDDLTG
DLFQVDNLLSGKIESYRLEKRYRHKDGHYRWVLLAVSLVRDEQTGEPQHFITQVEDVHAR
KLAQQELERLSRRIQLAAEAGGVGIWEWDFTSAGITWDARMHALHSTDPAGGAPVVEQWI
AMLHPDDVSRVSGEMRQAIRGEARFDTEYRIARPDGNVRHVRAMAMVTRTDDGTAKALVG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDAAMHVTFMNPIAEQLTGWTMASA
NGLPLERVFRIVDEATGDPIPSPVEACLRTLAPAYLQDGAVLQSLTGERHDVQDSAAPVL
TARGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
RAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYMIRNHVRPDDVLARLGGDEFALLLKDC
TVDQAEQVCQGVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPEQNEDGAE
HRHIEILVRMVDEHGELIMPGAFIPAAERYDLMGHVDRWVIRNVLRGYGERLGAVPGLSV
SINLSANSLGEPFLLPFLHAELEASALPASRIRLEITETALINNMAAANRLVAEMRRAGC
TVSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVRTV
AEWVEDERTLDALRAIGVDYAQGYVIGRPVALDVFLAGCQQRDAQAS
>A0A447S658|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELTQLPNRRALFKQLALRFASARAQ
QQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLTAVARREDIVGRLGGDEFLIVGS
AQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGVVTCDPQSIDVEAALRAADEAMY
QDKKSRRQENFIHID
>A0A485IUC4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSLNEMRNGIYSTCPETQLQHYLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCG
CLLLFEAVKLLAQNQSIHTGSRCYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIA
ALRFYHYSDEEMRTKHTWQINTLGRDVIPIMNNIASLPGGHKPLNFTHILADGSLRHVQT
YAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPR
GYCLLLIDIDHFKSINDIHGHQKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHS
PIGRALILAEGIRQAVSEYQTLSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNR
VTRMPFDSSERRRSRDGAA
>A0A486UQE5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLTKFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITIALLILNALI
WPSVAYLASMMSKDMLSTEKKNMVLDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALTWMMISFVIVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLSVVSRHLSLKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSNLVITMVHIIQKKIKDL
SLPSHKDIYCTVSIGISCAENKESIIEWIKEADKMLYEVKRNGKNGYCMPNN
>A0A486PP20|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLTKFPDEKYISDRNSSFVKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITIALLILNALI
WPSVAYLASMMSKDMLSTEKKNMVLDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALTWMMISFVIVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLSVVSRHLSLKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSNLVITMVHIIQKKIKDL
SLPSHKDIYCTVSIGISCAENKESIIEWIKEADKMLYEVKRNGKNGYCMPNN
>A0A377XGJ5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAAQMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A377XA37|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDAQMQPWQLFSTRLGIAAMLISPVIVASSVEVINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A136MSC6|diguanylate cyclase|EC 2.7.7.65|Omnitrophica bacterium OLB16|TrEMBL
MNMAQSDDELLKPQDISVLVVDDDYSVIEVVEEMLRRAGFRVTAVTSGLEANRLLQNQEF
HVLLADLRMSPISGWDVIRQAKEFGNTEVIVMTGYASLDSSLEALHHRVFDFLQKPIDFS
RLERAIRNAAHHNILTKRNRELTQELAAKNRQLEEEVRRVRAEMEVLATHDELTGLFNYR
YLQNLLSKEVARALRYHHPLSLAMLDLDHFKILNDFHGHTVGNRVLSRIAKILQDGIRQS
DCVCRFGGEEFAIVLPVTSKQQAEPILQRVCNAIKKERILLDESRILTCSAGLASVPEDA
GTVDDLLRLADDALYMAKAGGRDRVVLALPQGIK
>A0A5B9PC03|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MRLELQILVLLLLSVAMLVFHHLVPRTMVVGFSGDYWEFSSSHDEAGSESCPQVTDRGAE
LKMDVVNSSKDPYAAALFRRIGDNTAMNLDWFTKISLTAYIEGREEEYFRIQFRNRIPGI
YNDDDPVSRQYNEALFELSESPQTLEFSKEHFHVPGWWAEEYGQGFDDSIASFNQVDAFE
IITGSSVSETEVTLVVEEIKLVGHWIPPIVLYRTLLSSWMILALGVVLQKSLDLRQALRQ
SAERENRLRSLNVSLKSQATTLSQLAQEDALTGLLNRRGITQRIHEAMLREECSTQISLA
LLDIDNFKIVNDKHGHNFGDDVLTDLSKLFSFRENGCELFARWGGEEFLIVFFARSGAEA
REYCEDLRTQIQNVIGITCSFGVCEAMPEEPFHDALERADRAMYEAKSRGRNKVVAYSEI
TPRTNMGASEPASQFTG
>A0A445N2J3|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfobacterium sp|TrEMBL
MNQKETALWELIDKMEQQLSQFQDKMDISQIWEIFLDDIKNLINIEFSALFLENENTHEF
ILHQVTPSARKDICKEEQLLQIECGMFASIIKRRRPGLVPSLAYKGNKKLMLFILPFSTV
KRTRGVAFLFTQIEESSLTKEDDRHMEISTKLCSLVIDNTLLYEEKKSLSITDSLTGSYN
RTYLIEHLPQEIKRATRYGRPLSLVLCDIDHFKNINDKYGHQIGDRVLREFVQCLTDLIR
SDLDWLARYGGEEFLLVLPETDVKSAVSQAERLRKNLSKRVIETPENRLHITASFGVTGF
SPVSPEDKIHYEALINCADKYMYQAKHEGRNRVIGGPFAAQI
>A0A2Z2NQR2|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MNSRTIKRISRSRYCLWLVWFLICLAPVGHPLADIGGYADPLEPPVSVLEDPTGELTIAD
IVAADEQFSTSIGASFNFGFTRSAYWFATQLERPANGNSLFLKISYPLLDQIDLYLRSDD
GRNKQFAAGDSFEFDTRQVNHRAFIFPIFFEPGEQTLQVYLRVKTTSAMQVPISVWDPEA
FHSESYDEQIVLGLYYGLLLAIMVSNIMLALSVREPVYAYYSAYIMFYGGFQLCLNGLAF
EYLWPTSTYLAQKGTVMFMALSAVMATAFSAEILEIKKESGRLRACFIAFGLINMGSVLL
CIALPYSIAIQLQTLLTTAGTILFFCAGMMQLRRGVAAARYYLFAWTMFLLGIFIYSLKT
YAVLPENVFTEYAIQVGSAMETLLLSFAIAHRFKVLREDKLRLQSESTELLETRVSERTL
ELEQTLLELSTVNSRLEKLSIVDPLSGLFNRAYFNGNFDRMWKLAQEEQRSMAMLMIDID
HFKQVNDKHGHLVGDNVISVVSKLISDTVSRKEDFVVRYGGEEFAVVLPDTDLQMATVLA
EKIRVAVNEFVSELEAVSRVGRISVSIGVAGGIPAAADSEAGSETLLSQADSALYDAKNQ
GRNRVCRAPDSHSQEPFNDPDFRKVHLG
>W6K7I1|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MTGTQTNKRKETLKDQANRLKAMFETVVDGIVTIDQEGIIESFNPSAEVLFGYTESEVIG
ENVSMLMGEPHRAKHDAYLKRYLKTGEKRIIGQGREVLGRRKDGRFFDMELAVSEMAVGE
RRMFTGVIRDISDRRGYSRLLNAVTTAQQEISRKADSRFIFEKLLNELLDLTQSEYGFIG
EVSYTDEGKPFLTTLAITNIAWDDEIRKFYEENAPEGLKFTNTETLFGRVLTSCKPVLSN
SPSADPRSGGLPKGHPSLDAFLGLPFFSREEFVGMVGIANRPGGYSEDLIDFLQPFLVTC
SNLIITLRTEKRREEAETTLRESEARGRAILTGATEAIITVDETGNIEEANPATEKIFGY
RIDELTGNNVRMLMPEPFKKEHDGYLDAYLKTGIAKIIGKGREVVGQRKDGTTFPMFLSV
NHITIGGRNMFTGVIRDISEQKRSAEELKRLNEDLSQRVGALDALNDVNSQINRMNAFFQ
AAESQEELWDALVKYGADLFDGEKGAYFNVIENRVAEMAVGWGGEYRCETDFKVGDCWAL
RQGEPKVLESPDDHLICRHLDRDCLDHAICCPVNTRDGAVGLLTLYGPPESKASSERIAR
NRDVLASVAERLGTAIANLRLRERLHQDSVRDPLTKLYNRRFFDETLELEMRRSKRSGAP
ISMLLVDADHFKSFNDQHGHEAGDVVLQAVAQILRDNCRQEDLPCRYGGEEFALVFVGLD
KERALVKAEAVRQAVEEAVIEYNGKPLPKLTISCGLATIPTDAGDQFECLRLADAALYAA
KDGGRNQVISAAAI
>A0A1Z3HHN6|diguanylate cyclase|EC 2.7.7.65|Halomicronema hongdechloris C2206|TrEMBL
MPLLKSRVKQALRRVIHKPTLRLVFTVPVLLQLVGAVGLVGYLSFRNGQQAVQDLASQLR
SEISARIRRELQGYFGDPHAINRLNASAFTYGDLDVVDARYGEHLLFQQMKIYPTIAFVY
CGSAKGGEFFGILRSPETGQLQLSYGNAANNFFRDYYSLDVRGQRLHRLYQADRPFDSRQ
RPWYRAAVETERPTWTDVYIAFTTGLPNVTASLPVYDQWGRQLLGVCATDVVLPEEFRTF
LTNLEVGDSGQAFVIDRQGHLISSSTDEPLMVGTGEDAQFLMAVDSENPLVRQSVQHLLQ
RYQRLQSIQTPEQWAFEVDGERQFLEVLPFNDPFGLDWLILVVVPESDFMAQIHANTRTT
VILCLVALLLAMVIGILSTRWVTSPILQLNAAVKEIAAGHYNRLVSVDRPDEVGELAKSF
NSMVLRLQHSFQRLETQRNAFARFFPREYLTFLNKASVTEIELGDHVSKEMAVMFSDIRY
FTSLAEKMAPQETFDFINTYLQKISPEIRAYQGFVVKFIGDGMMAIFPKRVEDALDAGIA
QFQRVREYNAQRQTTGDFAIEIGIGIHVGHLMLGMIGEHHRIQGDALSDTVNLAARLEGL
TKFFGVSLLMSGQVLQQLQDPSRYLIRSLGQAIVRGRTEPIAIYEVLDAEAEAERHLKQQ
TLPQFEQGVAAYCDRNLTLAQACFQQVLAVHPGDRIAQLYLERTNRLLADGIPADWVGVW
SFTQKR
>A0A3M2RC10|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MSQGRPEDNGTAPLQANRSPLRRALWAAFVYLLVGLAWIGFSDQLAEAWVQDARALSEVQ
TWKGFLFVGVTGITLFIVMFRQLRKDRLLLMVQVRQRKVMREHERQLTVLLNNLPGMAFR
FRNDQLGSFIFISDGCEELTGYSAEELMRKGSLSKSGLMGDDSRYAIAQEVAESIRQQGF
FSIEFPITRKDGRDLWVWARGTGLTDDEGSRLLEGIVLDVSRQKALEQELEELATKDPLT
GLLNRRELSRILAEELERAHRYHRSLAILWIDFDHFKKVNDRYGHAAGDLVLSTASRILD
SSVRGVDSVGRFGGEEFVVVLPEMGQTEALDTAERLRQAVRDKPVILASGDQVSVTASIG
IAVYPIHGSCVEELSAEADKAMYRAKMQGRDCVAIAQPARPIHNEAT
>A0A1V5J495|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.BinA014|TrEMBL
MLGQSTPEKLADGGITWHGFNTDVTEQKLLEETLRESEKKYKFLIENMRDILWTMDLDLR
TLYVTPSIEIVLGFSPEERLRQSIHEQLTPGSLSIARELLTKELDLESQNNSIPERKVIL
ELEFYHKNGSTRWLETIISGIRDKQGTLIGLYGVSRDITKRKKMQEALRESEQRFSSIIA
TSQEWIWSLDIEGFHTFSNPAVEKILGYTADEIVGHKWQHLIHKDDKPKAEKTLAQSIKN
KKGWTNLLLRWRHKDGTYRYLESNAVSILDNNGTLIGLQGADRDITKRVRAENALKESES
KYRELSIIDGLTQLYNFRHYYRAIRMEINRAIRYQQPLTILFIDLDNFKQYNDAHGHLEG
DKILSHLGNTIKNHMRQADSAYRYGGEEFILVLPMTNSTNGAVVAERIRAEFKKENFSTV
PGKIIHMTISVGIAQHRPGEDIKTFTNRADQLMYRAKQNGKDRSCSDAEKE
>A0A1C3JW08|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MIQHVLTRCLGVEPSDKDYRQLSLTLSAAVVCTMIAAFFCGYNTLVKLYWPLLIIDMIAV
MLGLLTLFVLLRLKSPQVAKVILLLMVALVCFSVMEVRGNQSYSLAWAFLCPPLSIFLLG
YIYGTIFSGVYLACLCALMLMNGEVWEDAAWQGGAFTNLVMIYLGLFAFACHYEASRRTA
QKLLRESNEKLAQLAHQDPLTGLYNRRYLEDQMLQMDNESIFLAMVDVDDFKRINDAFGH
EKGDQALTQMGDLLREIIGTEGVVGRWGGEEFVILHYADQPSVFIALLERLVAGVAEHSF
SDVPPITISVGATTYYKGRHKASLRYVDDALYDAKESGKNRYAIMHHVVDE
>A0A1C3JVU1|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MVQYLMSRYLGIDKQNEQYRQVSLILIYTISCICITTFYCFYNTVIFDFPRMFYIDLAGT
LIGVAALYTLLGLKRVQLASLILMLMAGGIILLVLLERGNQKYSLAWVMVVPVMSIFLLG
YLWGAVYSLVYLAIVAFLGKQGLLVWQPSPWDTGSFINVIAIYVLLFMFSCYFEASRRAA
YKLLLQSNRKLALLASSDVLTGLRNRRSLEDYLLTHTDTQQYLAIIDVDDFKHINDHFGH
NVGDDVLIALAAIMQDCVGDLGLVGRWGGEEFVVIYDASELSEFTRLLATLNHKVYQHSF
GLTQPVSISIGGCVHIGSDYKASLRAADAALYDVKVSGKNAYKMAGE
>A0A485AA52|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MLLTRDMPMLNSEQSINIQTQSSRSGMNLFSALLIIIAVSALCIVISKPLGPWDVIFANA
GLYIDLLALLFLVFMLWISAKVRMSYVAVNWVRYGLLLWIAGCTFDVMDEIFVQPKWMGY
YCEDLLRLSGMLLTTIGIYKIIERINVLYVDARSQSLKDELTQLPNRRFFIDTIREKQGH
QLALMILDIDFFKNINDTYGHLVGDEVLFALGKQLAKLTSDKILPARIGGEEFAIIVDGM
PAEEVRNLAQSILENVRSILINHDYPLSVSIGVGMREKGEAQDAFIKKVDEALYQAKHNG
RGRVEWATS
>A0A1C3JW23|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MKGRTCLIRNRLGLLFLLLISLAGTSHGQDILTPEERLWLDQQPVIRFAPAPNFPPVEFF
NEDNEYQGITADFIKIIDQQLNLGQKLEIVQLKDWGEVMSEGRSRGIDMWGAAEKTVARS
QYMQFTEPYIRLPAVIIVRQEFAGDGIEALVGKKVVGIENYASYEHLQENYPQLNALGVP
DIEAGLRMVSYGAADAIVANNAAAIYYIEKNGLTNLKVIGESGFEWNLRFAVRDDWAPLL
SIMQKSLDSITALQKRDIYRYWINLDSSDSWKFTKDYMLIAMAGALVVIVLVLFGWGWRK
RAAVNMQRLTQRIEEQKKIEEELKNLATTDELTGTYNRRAILEIAQTDYQKCLDEGQPFS
VLLIDIDHFKQVNDQYGHEVGDRVIRAIVNVCSDILKVKKIGHIGRIGGEEFVVLLPMID
QTEAHSVAEQLRQCVEKEPIQCIENTWYSATVSVGLASLEHSEKFDELLNRADMAMYQAK
KSGRNRVAVSHELVAG
>A0A564T6T6|diguanylate cyclase|EC 2.7.7.65|[Ruminococcus] torques|TrEMBL
MKKKIKIQNTIYWSIVVTLIFTVLFIFICIFNQKQFHSFQESSQQYILCKDSVEQLEEGC
DYLVEQARLYAMTGNEYYMDLYFREAHMTKRREHALKQLEEYFDGTQTFTSLKSALKSSG
DLMSIDYYSMRLIADANGISEDSLQQEVAAVKLTDEDALLSSEEKLKKASSILCDNTYQA
LLVQTKANVANCTQSLLDYTQKKQNRAQIIFFDSFRNLKISTFLMVFLMLAFCFTIRHLI
VKPLISYNECIRLGEIFPVLGAVELQNLAITYNQVYRENQQTQQLIRHQAEYDALTDCFN
RRSFNKFLSLYETDAENHPFALILIDIDVFKSVNDTYGHAIGDVILKKVADYLKAAFRNN
DYVCRIGGDEFAILMVEMTTDLQYTIKKKIDSVNQQLSLPEKGIPKVSLSAGVAFSDREN
PGENIFEDADKALYKVKENGRNGCGFY
>A0A2X2G7D8|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MTNNDTPNMTAQSWQKHYDKKYQYSLRLFLLLTFISAVFSLVSPLYTPVSFTLPCVLIVI
LSAALALWHWKFSQRKINIPFISLIFGVLWASHITEKALLLPAPHFNFLVIALLSILFIG
AIAFPNNITAFTLHSLPTFIACLFLAEGEQWLRMLYCLTLPIAGITLQNIIQKRSDAFTQ
GLMDKLLQERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLAVSDSDHHVLLLDIDHFKAYN
DHYGHMMGDQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTNSTTEAASLAAERIRQQV
YDLKIPHMFNESVATNVTISIGMTPLMDSDIDGALKRADTALYEAKGQGRNIILAS
>A0A011PU71|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MPHSPFRLPLVDLCADDDEIARYAALLDTLDIGLLVFRCDGSLQLRNPQASSLLGDTETL
WEDENGMALSNDQRLEQQVLRTRQAIRQRRIGLRKDASAAATLCNASAFPVLAEDGSLRC
VLLTLSEIAQHPTKTGDALQRAAHDSISGTYSPADILQLLDDEGRRATRYGTPFSLALIG
IDHFPELCREHGAQAGERALADVGRLLGESLRDADMVGGFRADKFLLILPNVRVNDATVG
LERLRELVETRHASAEGEPLTISGGVCEFTGEDSAALIENVRSLLAAAREAGGNRLCVNL
DFF
>A0A7X1BLV6|diguanylate cyclase|EC 2.7.7.65|Citrobacter cronae|TrEMBL
MMRNTMEIDAILIELNKSIDAHYKWLVNMFRCAVTSNATQPDIMGDNAHFVCQFGQWLNN
QSLRNEDDCSYVNKINTVHEKMHLSGKDLLLAILEKRSYPWHFTKFEDALLAFTSAVMDY
KIYLLSIRSNIDILTGLPGRRMLDESFDQQLIDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDVVLRALAANFLAWTRYDEQAYRYGGEEFIIIIRTKTDEQARQAGLRLCQLVGQQKIPY
ADGEIAITVTGGITRAQRDEKLDTALGRADRAMYQGKQSGRNRCMFMDEREQITLVNASD
GLSFHLSA
>A0A379JTR6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MALIDLDHFKCLNDECGHLVGDDVLKAVAQHLLDNLRSTDAVFRIGGEEFLLILPGADPR
EASERLQSICAQLATRDVATRGGDQRVTLSAGLAHWPEQGQALDELLQAADAALYQAKRD
GRNRVCWLLAGADLSHPSRQAALRGDSG
>A0A5C6BZA7|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Poly21|TrEMBL
MNDQVADALSSVPSGIFSVQPSAIVGGIDSASSLGFYKTLADSLQDGIAFLNANGRVRYW
NPAMVQLTGIAAGDTVGTSWNSAGLHFVSVNPTESVECPVAACLQTQTAMSQTMKIVGSR
PGDLSLRLGPGTRAQLVAKQAGRDVLVNAIPVDTPHDGGAVVIVRDLSDRIEMQSQILSL
HKKAMSDPLTGVANRSEFDQCLLRCASEASQQGATFSLIMCDIDHFKRINDVHGHPAGDK
ALIQFADVLRRHTRSSDLIVRYGGEEFVVLAVNSDKATATRRANEIRRAVAATPLDGIAG
QSITVSIGVAEYQNGDTPASIVARADRALLDAKATGRNRVV
>A0A379JN50|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MPTQTARLLKRLRNDFQLSIITLMGLFGVIGISPYAVYRLLEGNYLVGIADTIIVLSTLF
AVRYAWLTRDTVKPGIFLAAVFSIAATLIVINLGVNGLFWIYPLILFNFFMVTPGKALLA
SSLVLGSLTSHALLIPGSVFESHYQMVSFLVTCLMASVLSFIFAFRTRNQRDQLQEMVLH
DPLTGARNRRAMNEELKIAMASHRRHSDSYGLLVMDLDHFKQINDRFGHHVGDQVLVAFV
ELIMRCSRKEDRLFRFGGEEFLLLLPNTDTEGLRTAARHLLDKVASELESPGGAVTVSIG
GAILHSGEHWENWLQRADECLYRAKSEGRNRAVIADAPNGQSKAATSH
>A0A7L6Z2Z6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C15|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A517YSB4|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MNLLDQILESPQLPTLPRIAVRVIELCKSDRCELQELVDVISTDPGLTVKLLASVNSSYY
GLNREVVTVSEATKLLGLRAVKTLTIAFCLSQVISEQCPHDFDLEGFWRRCLYSAVAAKL
MAERIGSDIEEEAFTAALVQDIGLAAMVQVIGRDYQELMKSTGSNHSVLNRIEQNQLSTD
HAQVGASLADRWGLPEILIDAIRYHHNPEDYKGENQQVVQIVNLSSLVADALSPEQIAVA
TISTFSSQLEEWLGIPEEQAHDLLNDVEEKSRKLGGSFKIKPRPQRDINKLLIQANDRLI
KMAIESNQRLVELEKKNYQLKAAAQRDPLTGLANRRMFDSSLREGYLKSSEADFPLSLIL
FDIDHFKKINDEYGHLAGDRVLIMIARLLQEHEPDGGCIARFGGEEFTLVLPRLGVASAA
QIAEHMRSRIEQLRFDIGGGKRIHATVSAGVAGRDHLRQLSSEIELLDCADKALYAAKSS
GRNCVRVLRPMMMPRVTPDKPCDQAVD
>A0A7L6Z1R7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C15|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRRLASEIAIAHAHALSIEFYRIVLADPHAEEFLSNEQ
VERQLKSALEKWIVDVLSSEVDNIDELIKIQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDSHHEATHKLLVYHFSINSIDLAMEVMSRAFSFSESTAAKEDENYRIFSLLENAEE
EKERQIAALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTTKTLSNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPAGDFIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A655UEE3|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MINSLNRKMTLLFIASLLLVGFIAFSLLNLDQRQQQTNAELDTILEIQNSIAMLRSQLWV
FLQYNDAHSLEQVYRAQQVLAGQLEMETVFGQHLAGIQRMNNSLAGLLEQERYMAEESGI
TKLVDGIGTYELLHSRYNILVQNMNEELAYFQRQVMEESINNQRYLLLTTMAHLLLFSSV
VCGIALVVLRRFRHGCKTLQEGIEQMAKGDLASRISTQNNEQEFVQLTQFFNQMKASLQS
TTVTKDELQAEVARKTAKLERQKAELRFLSERDSLTGILNRXXXXXXXXXXXXXXQLSHA
LIKAKRSNMKLALLFFDLDKFKEINDTKGHEVGDLVLQEIAQRLKGSIRESDFCGRLGGD
EFVVCLDLLQDHSGVINKAYQMLEKLQKPLQLNQESLEIGVSIGVALYPEQATQVPELLR
IADEAMYTAKHQSGNTVYCAHQDKHDHTSLVS
>A0A655VND9|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MSDSKDIRHSTNFLNNQLNAATLEISRLKEQLAKVQKDALFDSLSGLYNRRAFDGDMFTL
IHAGQQVSLIMLDIDHFKALNDNYGHLFGDQIIRAIAKRLQSLCRDGVTAYRYGGEEFAL
IAPHKSLRIARQFAESVRRSIEKLTVKDRRSGQSVGSITASFGVVEKIEGDSLESLIGRA
DGLLYEAKNLGRNRVMPL
>A0A3B8TYC1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp|TrEMBL
MTQISTEQLIKEWQVLLESTPKSIYHCAQQLAQQHAPQLAESFYKHMLEDPHAAQFLSNE
QVQERLSGSMQNWIITLFSLTADEDLRPVIAQQKHIGDVHARIDIPVHLVLRGARVLKET
VARLLNGHAEQAECLIFTSALIDMAMEVMSQAYSASNDKNSRAE
>A0A518KCK3|diguanylate cyclase|EC 2.7.7.65|Botrimarina mediterranea|TrEMBL
MSSTALPIDNAPAASVGQGASEHSPAGPDIGSLLRSVDAAAVSHGKSSPEQRAAGAAEQH
RLVEGRLGMASSLFTALRCKHPSTADHSLRVAISCSAWAAALEMPDKLRTHLEAAALLHD
VGKIGVPDIVLNKPGRLTDIELEIIDSSREASRHILWAAGAPDEIVEGVAAASAWFDGTH
RSVSLKGDQTPFVARMIAIVDAFDSMTTDQVYRPARSRERAIATLYEQAGTQFDPDLVQS
FCDLFTQDQSQLEADVSARWLGSVSGIRMPWKHTHRESVTPTEAAPVGEGDLFTAKLIDN
MHDAVVFIDSQRVITQWNTGAEKLTGVGASAALGKALTPSLLDMASSSGNLIDDIACPIK
KALSDGLQALERISVMGRNGQSVTVDMHIIPVSSTGRPGHFVGAAVMMHDVSSEASLEER
CQALHAEMTKDPMTQVANRGEFDRMLAAFVEAHLDTDLRCSLIMADIDHFKSINDTFGHQ
AGDEAIMTFANLMKSMCRAGDLVARYGGEEFAILCADCNNATAAKRADAIRKKLSETPHS
YLGGKQITASFGVTELQPGDTPETLLRRSDRALLQAKDQGRNQVVQLGDGMQTDNASKAG
WGGIGKWFLGSITGGSGALIETRLVTNVPIELAVDKLRGFIADRDAEIVKTSENYIRLIT
EEAAAGGNRRDADQAISFVVEIELTQTHIERVNNSGLAAGKYVHTYANVKIQPRRDRDRS
KAKVVDRARKLLSSLQAYLMAKEATVESEPTT
>A0A7Z8BDL7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7Z8FC03|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A7Z8BFC7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHTWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAK
>A0A8B3KAR7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIINQVPIKIKIFIFLFSCISIIFLLLHENNGIYITQTTQISYSVFIIGLFFINLMIFIF
LLLYYVSNQRQSYLLILSFAFLSNTYYLLEVAIISLSPFGNDLSTIYQKSNDIAIYYLFR
QFSFISIIFLAIYSTNVKNKSVLEDKRNIIIVVLSILILFITPFVAKNLSSDNIKYSLNI
IQYSLNRHLPTWNIVYTKIISVFWLVLLISSCISIRNYSKIWLCIILISIVSVCNNLILL
YFIDKSHPAWYMTKFLELISMIYIISTLMYYVFRKLNHANHMAIHDPLTNTYNRRYFIDS
LKNISKHHDFSVIMLDIDSFKSINDKWGHHMGDQVIVMVTRIIKKSIRKEDILGRLGGEE
FGIIIKGNTQKLLLSIAERIRKNIEEQCSEKLLSHGPEKITVSIGCFTSKENNLSPSEML
VNADKALYQAKRTGKNKVIIHSK
>A0A8G1LZI8|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MTILKSNERLALRKSVIELRQIQSLGKSYLQHAESERARMLALLAAMRFGVLFVDNDHRI
VFFNPAFCEIWGLSSSQAMIGRPVGQVLQLADNRPALSDVLSCYLEEHTALEDRVDFGEV
TLNDRRVIVQNCYRVTDPQGVTNGRMWVYEDVTQQRLIAERMVNLAERDALTGLFNRHRF
QQELERMVSEANRRDQQMALVFFDLDEFKLVNDSFGIPLAMNCLKILRVKSISKCVDMKS
LRVWVAMNLRCYYPLAMSLK
>A0A7Z1D0M1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A7Z8BW53|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A656BZ88|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDL
KALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKIYRFGGDEF
AVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKK
NGRAQISWQ
>A0A7Z1D3B1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>D2AHI4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A4P7D7E6|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia pallida|TrEMBL
MLSLTVAPSRQLGRGATTQPGMVGDTMQRSAKGTAGRTRPDRFSSIVMKRPRLVVTLCFV
GAMTLVTIVGLRQLYNTARNDLQNRQRDLEVRAVGVDALIDSERRRLLFLRNYAEHVLAS
ERQQRIGIQNPAVQTVLGEISQPVWQTPGSLGGPIVYGTNAAGLAGLDGFHRDAALLPGD
IALARTLSPLVEISQHADAVQSTVAFISSNGVFVIAPEHQALSVPELLRRFNTMNYYRGQ
LPERNPNRDVLWTPVYSGLQKGEAISTLSAPVYFGNQFRGAVVMDITQSRLLSLQLSTGA
PVDEEGDPVEFGLLNTNGSIVYFRNGVLIDERPARFSASLLQTAKASVDKWMQRGSGYIE
RNGQYLLYRRIGQSHWMLMAATSNAELTLATARRVLSSPLIAAWVVLGVLLVGTLRIVTN
IFGHYVEASERLETLARSDPLTGLANRRRFQEAFAEMLERANRASQQPVALAVLMLDIDF
FKRVNDRFGHAAGDRVLTVLAGILRANLRSVDLPARTGGEEFAALLPDADLATATAVAER
VRLAVEAHARDAAAPASAAHPEAIAFTVSIGVATSPADCRADYEALMQVADRRLYVAKES
GRNRVVDVDAQVPDARA
>A0A174HSD8|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MNKKKDITYIDFDKWNDKIIKVGIITYVITIFIELLLFRLYKPTVWCSRRQYFNGIILTP
TIFQGIALIYIIFIAKVLSKFVNQYITTMLLIIGEVGYTLVAVAVHTSVEFMCIVLMYPI
LFTSAYKDKFFCWYTCTISILGYILLKFGVIPSVEYRIYNSSVVYCIIFTTLLVFIAIWS
LVMKKINVEFDTNAEKLREEASIMKTAAEKDSLTNLYNHNSFYERLNDRIDKIKPQEKLH
LIVVDIDNFKSINDTYGHIAGDKVIIHLSNVIKKTLNKFDFASRYGGEEFVGVYNNISEN
EVIDIANKIKDECKNAIIKYELLGDKPFEIRYTVSIGVTSYIKDVKSGTEMFEYADKGLY
EAKQTGKNKVIFNKVKA
>A0A806TU98|diguanylate cyclase|EC 2.7.7.65|Priestia megaterium Q3|TrEMBL
MLKDHMFEFYFDQMNELVFLAEVKNQHLYYKKMNKAAAKLVRYQGEVGMRLESVLPERAY
HSLYPYYIKAMETKKPVTYHDINTFSDEAEAFETTLTPIFDDTDNSTHLLVMSKNIQKLK
KDLAQSMERYKSLFMNHENAICMMDLSGKIVQANPACEQMFGYDTQEIINSSYMQLLEEL
KIDVRALPLHHIIYDQSYSKEIQAWHKEKGIIYLYVTNVPIIVENEWMGIYLIAQDVTKE
KTAEIKLENTVKDLANMKYALDESAIVSVLDPYGTIRYVNDMFCTIFGYEKEELIGQSYE
LFDVSYDFRVLESIGQGKVWRGQVKSITKEGVIVWSHKTIVPLTDIHHRISSYVLIQTDI
TAQKNLENQLKFKAFHDSLTGVPNRMMLQKQVQAAIEQKERFGLLFLDCDNFKEVNDQFG
HDIGDAFLIQYAHRLTSCIRTCDEAYRLGGDEFVILLRHIERREEIQQIMERIHRELQKE
WSIESCIFTATSTIGAAYYPENGESFQELLKQADQALYEGKRQGKNNVNFYKKNQSVADS
IDKESIV
>A0A7W8YNQ4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. S3M3|TrEMBL
MPEFSSSLPQYEPALTEFKVSVLLIDDQLIIAEAIRRMLSDQQDIEFHYVTDATQALDTA
LRLQPTVILQDLVLPGTDGFALIKLYREQEALAHVPVIVLSAKDDPKLKAYSFAVGANDY
VVKLPDKLELLARIRYHSNAHISRLQRDQAFRFLRESQKNLADANIELQKLAALDGLTGI
ANRRRFDETLHFEWQRGQRDKAPLSLLFCDIDHFKSYNDQFGHLAGDLCLKKVAAVLTEH
LKRPADLAARYGGEEFALILPETELAGALQIAEACRRQLEGMQIENPAAGTGIVTMSIGV
ATVVPSPKSTVEALINRADQALYTAKRGGRNSVLSAEETGD
>A0A1Y3KLZ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 1239|TrEMBL
MPSVSPEVQAKEWHSMVSQYPCTLTQSLQGLVERNKVMLAARFYEHMLADPNASLILSHD
EVKSRLGSSMQAWLVRVYSVSPTDDCMPLVALQKQVGEVHARIDVPLHLVLSGARHLKKL
LFQLILEQQWASEAQALRLASETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNIST
ERERQRGALLDWENSLMFDLAMGSNGVNLPRLAASDFGLWFRHKGAYAFQNTSESDQILK
IIRHMDDVLLPMFLASMHEQETRMRLLRDIRDQTKSLMFNLDNLFNTANELESGRDVLTR
MLNRKFLPVVIGNEIAIAQKTGQTFSVFSVDIDNFKSINDNFGHEAGDAILQQIAEILSS
HSRAGDYVFRMGGEEFLMILVDIDSANAMKVAQKLRRKVEAEKLQLTEGRRHQVTVSIGM
ATYNGHPDYQHLLRQADQAMYQAKQGGRNRVVAYGELTSPE
>A0A0M2WN26|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MLPLHRNSLIAAALALPLFLFLYATLGHPKPIAIWKWMDIVCEGGTAVMAGIWFLFTLSS
RPRGLVTSLIAGGLCAIMLGSWADCLDEFFAVDKSAVWDNWLEGLIPFGMLLVTIGMYYW
RQEQFRLNEHLQKRERLFRDHRAFDRITQLADASYLRTQMRLEQERRPGLDCALVLLDID
SFHLINREYGHREGDRVLQAVGHMLLLNLRNDDLLCRYAGDRFAVLMPGVSREDAAVKAR
HLCAMVGQMRHYANDNREIRLSLRHACSLTDGVPEVVLAELSRAVETPRSGAGISSAAPA
>A0A0M2WQJ8|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MDIKTLVLALALGNLSLCAALFFFEYERKKSLSMSTWAIAKQCQAVAWCLLYFRGVLPDF
LSILLGNSLLFAGMALDAGALWQAAGRSGWRRTVLPALGLSVALFAACYLFDVAPLLRSA
GGSLIVAGFFLSGVAALSLKWREASMLRRFLVVSMGLLSLLIAVRGVLAAAVPGFDAELM
QLAGFGALYLMMLTNAFGYLLLSREKLGGELARLEVLDAATGVPNRRGFYQALAPWMALA
RRPGLPTALVVLNIDHFKRVNDSYGHPVGDAVLKTIVDTCRQQLRDSDLMGRLGGAEFAI
QLPRTTLADALMVAERIRAAVEALPVKTERAVLQLTASLGVTTIRAEDSTVSLFKRADEA
LQSAKQAGRNRVVEAQAASTLDM
>A0A8E6J8Q2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2T0B7U7|diguanylate cyclase|EC 2.7.7.65|Clostridium luticellarii|TrEMBL
MNKETLIKILREKDVVLEKLYMEREKLNYYASTDVMTGVLNRRSGLKLLDKELNLSKIGN
INLIICFVDVDELKTVNDNFGHQEGDKILINTAKILKDSIRRTDFVIRMGGDEFLVVFPG
VTMEEVHKIWHRIEEKLKACNENNGNYNFSLSCGLCECRKGMQSEMSVEDLIKNADFEMY
NEKLQKKKEL
>A0A735PZG9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:z:1,5|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A449INP5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fragi|TrEMBL
MKGPLYMVFSSEGQAIKYHLRTPVITRRMLVWASALSVVAIVNIVGYLLVREYRNTEDDA
ARSALNIVQLISRDIRNTISTYDSALNSLVSLVQSQALASLSPQTQQPLLFDRAAKAPSN
AGFFVLDADGKVIAGSRPVEPLLNNARQQSWFKVHLKGQTEGIFISRPLPASDAPNDWSL
VLSRRITTPDGRFGGVAVALMKMSYFQNLFRGLDLGPKGNISLVSSEGIMLIQYPATTMF
YTGQDLGHTPIFLRFLTERHGSFTAVSGIYHLQRLYNFAQISELPLLVVVALSTEHIFSN
WRHTALLIGSATLLLCLGLLWLTWLLVRELRLRQRAEGELAALAATDPLTGLANRRMLDK
TLDLEWRRAQRTGAPLSLIMIDIDHFKPFNDAYGHQAGDEALRQVARVIKANVRRPADLV
ARYGGEEFAVVLTETDAAGTRLLAEKIRAAVEQMEPVDPTTKKLTVSLGACTRYAKPGDD
REELLSTADKALYQAKKRGRNRVMDINETGLNALKPKNET
>A0A379CIX8|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MNDKKRLLWLSYSFVLISLLVTLFFFLHAQSRYLQYKTLLLNEINAVFLDSYAQLRNLYV
AYNNVPFLPANELLMRNKQFAHIKFIPLPNADLQTLRAPDIFANLQQIKQNLDFITHNHL
ATLGLIQYARDYVIVTPYRPYHDLLFSRQADQALQQMSRIDPTWQQRPYDAGDFRGCRVY
ITTPYRENYSGLKLVSMLMPLYTEGKLQAVAIADIRSMIFRHITASFNQQHNTQFFLNDA
NTPDSFLLPCSQQRINIAYSKLSLLSASDLLIALASASTLVLLLAWVLRVKNKIYRDELT
GLHNRYYVNDHLRRLPSGFSVLVLDVDNFKQVNDRHGHAIGDQVLQTIAQVLQNLTRDDD
IVARWGGEEFLLLLMTDREDTVRHRAELIRRTIADESALTGLPVTVSIGVCIARAQAFET
AFKLADDCLYESKRNGKNQVTVSHLF
>B1EQB3|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii (strain TW07627)|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>G8SMI6|diguanylate cyclase|EC 2.7.7.65|Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)|TrEMBL
MGWLDQLAEHADDLRRAGGLQQNGRSAQALPILDAVLSTATDPTTRAYALIQRFGALINL
GRVAELAVAMAAAAEAVREVPDPYLRGQMHAFAALGAHLQSNLDRGVTHLVQAARSLAAV
PEADEETAWGWHDLAMAYSYLGFHGQALTAIEQAREVGASAGLTPEVFAAPGIRLRNAVS
LDHQGDTDGCLRVLRDIDAELSRYVATDQLRPGSRAVYGYALARRAALGEPTEDGAARWL
TGGGDSVRTRDLQHLGAVCLTIAAGKPERALTMLETVPVSAEVLGAPEPARLRSICHASA
GDHAAAHAADRYAFRLAAQRIDQLRDGYLDGVAARLDAQETQRDPHRYGDETLTDPLTGL
PNRRQLEHYVDALLARGERAAIGVCDIVGFTTVNMRHGRHCGDLVLQRIAGVLARVMRRG
DFVARFAGDEFVLVLPGAGPHQAAEVSRRISAAAAAENWQVLVPGTPIGLAAGWSEVGTN
GRGLGAALAAAAASRKPT
>A0A381G3Z5|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MNDENFYKQPVDLDETALSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPMSREFANLKTDAVLAGMWMGLMGVNALPSAA
LLMIICMNLMGAGGVRLFVTGLALMVVACLVTLQLTGTSLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATRLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHREATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRITLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRIHEGLRGLRLACAPQVILHISVGVAPLTPQFSHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A6I6DMC3|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 119287|TrEMBL
MFPKIMNDENFYSKVYAREGMSQAHSADEYHRAGIRLARRLRWPRAVGLGILFLPIASVL
VAQPVNGVWWLLLVGWAFVWPHLAWQLAARSTDPYNGEMFNLKVDAIVAGVWIGVMGINA
MPSAALVMMISMNLIGVGGIRLYGPGVMMTALAALVSLQLTRVTPDYVSTPLELWLALPV
IVFYPMLFAWVSFHTTSRLVEHKRRLELMSTLDGMTGVFNRRHWEVLLRTEYENCRRYHR
SATLLLIDIDHFKSINDTWGHDVGDQAIVAVTRQLQLTLRASDMIGRFGGDEFAVIMSGT
QAESAIAAMSRVHERLADLHLPGSPQVKISISVGVAPLTTSMVHYQEWLKAADIALYKAK
NAGRNRTEVAA
>A0A658YA55|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPAAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSKRLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A7Z8GLM1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMINI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A3T2UXL7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
LMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGD
EFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQE
LADHNMYQAKHQRAEKLVR
>A0A3T2V264|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
AANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYE
GKQTGRNRCMFIDEQNVINRV
>A0A7Z1ELD8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A8H9YUQ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MNKQYQRVLVTTPHPVLRLVSLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNILATGLLFSWESLNVWYPTINAIEAFVGALLLRKMLPWYNPLKN
LGDWIRLAIGSAAIPPLLGGVLAWLLVPSEEPLRNFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTMAVTLVLCWVAITFLPWPFTCVIVLLMWSAVRLPRLEAFLVFL
VTVIMVSLMMATNPTPMTTQNTSVMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIDGQWLQTNKALCEFLGYSQTELQSLTFQQLTWPEDLHTDL
ESLEQLARGDINSYSLEKRYYTRNGEVVWALLTVSVVRHTDGSPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLQPDVISWDKRMFEMYEIPAHIKPTWQLWNDSII
PEDRAYAEQVIRDSLMARVPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVDMHVTFMNPVAEKMSGWTQQEAMGQPI
LSVLHITFSENGPPMENIHSGDMSRSDINQDVVLHSRSGGTFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDGLTHLANRVSFESHLKRLLQNVHDTHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRIIHAINDYQFMWEGRLHRIGASAGITLLDDSNYQAAEVMSQADIACYASKNNGRGVV
TVYEPQQERIHSTRGMMSLDEQWHMIKDNQLLMTGRSVASPRIPESSNFWLISLRLWTSQ
GDVVEEQAFRSGLMEPDLLHALDRRIFQTFFRTYATQVATKGMGVALPLSAEGLSSTTLV
SELLDLLEKSPLQGRLLHLVIPVETLQNQDVNIQNGLQKLRLAGCRIVLCHVGRNMDVFN
HLTPHMADYLLLDPELVTNVHGNLMDEMMVSIIQGHAQRLGMKTIAGPSNQPLMMDTLSG
IGIDYIYGDCIAEPQPLELLLNTSYFAIN
>A0A381CBD6|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MESSTYLDEDRHRSGRRFARRLYIPRIIGLATGFFCVSSVLVLQPVSGWWWLLLVAYGFI
WPHFAWQTADRSSDPARAEIRNLMVDSLMGGVWIAVMGLNALPSALIFTMLCMNNVGCGG
VKLFGMGLGVILLSCLLTLGLAHIPLNLETMPSQVWICLPFLLVYPVYFGLVSYRTALKL
SEHKRRLMQMSTRDGMTGVYNRRHWEHLLHSEYDNCQRYQRSATLLLIDIDHFKSINDSF
GHDVGDEAILAITEHLQLSLRITDVIGRFGGDEFGVIMSGTPQESAIQAMARVRDYLDEF
RLPRAPHVPLRISVGVAEFNKHMVNYREWLKAADVALYKAKNLGRSRTEVADIAA
>A0A381CAB7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MANLAKFMFCSPEKRLANAVSIFVITTLFYFFGASLRLIDELSLFWPLNAVLAAVFVRSP
FLNRPIYYFVCYSAMIVYDAFTTHWGWQSAIINLSNMVFIIVVARLLLRYSRTQDESNWA
LNAFNLFYACLIGAILSSLLGSMGSTGPSSDYRQFISLFSDWFSEQFSTGVLMMPFLLMA
KWPQWSKLPAFHLSKIYPLVAVVVSVMASVVIGGAGSLAFPLPALIWCAIRYPLPITALI
TFLTGGTEIILVANSIVVIHHNVPLVVTEMFSARLGIATMAICPLIVSVSVDAINRLIQQ
TSLRADYDYLTGVYSRSGLYEALKINMPTKHLPNQKLCVMLLDIDYFKRINDSYGHECGD
VVLAAFAEQLRKVVGDEGLVARLGGEEFVVACSTCTEEKGLAIAEKIRQTIELTAFRYQQ
QTLFITVSIGLATVTPEKQTLLDAFNSLLAEADKYLYLSKRNGRNQTSTASYKELALNS
>A0A1A9GIF5|diguanylate cyclase|EC 2.7.7.65|Nocardioides dokdonensis FR1436|TrEMBL
MVATGSPGTPHGSAPPPDVRSAVVRRLVAGSDRSSSLDRLCELAAALLDAGSAQVSLIGE
TQVVVGGHGAGSAAVGIETPAEDSLCTVTVGLGAPLVVPDAVADVRVGGLPPVTSGAVGA
YLGVPLVASGGQVVGALCVYDVAPHEWSPLDESTLQRLAQAVVGDLELAALSSDYEVQQV
AWRLATDAAGVGAWEWDLPSGELRFDDRLLEIFGFDHDSFGGTIEAFTDVVHVEDVPRVT
AALDRAIASCGEYAAEYRINLPGGGVRWIAARGRALGDERGQAVRVLGAAYDTTAVQEGE
ARVARVLESMPTAFFQLDRSWRFAYLNGEAERLLGRSREELAGQDIWTSFPAAVGSDFEH
HYRLSARTGEPVAFDAYYPEPLDAWYEVRGWPNPDGLAVYFVDVTARHRAQEQVVRTARR
DALVAAVTEQLAGTLDLEEAVARLGALVVPELGDWCVATLVEEPGHEGRLPGLRDVGGWH
RDRDAQPLVDRFAEVRLTRLVDQSFLPAVLAADRPIVATGATEGLCSIFEEGEVPDLVRR
LAPEHVAVVSLRGRDRVVGLLTVLRDSARGGFSGNDLDTLGQVAERAGLAVDNARLFAEQ
RDLAEGLQRSLLTAPPQPDHLEIVVRYEAAAETAQVGGDWYDAFVQDAGATMLVIGDVVG
HDTAAAAAMGQVRNLLRGVSVFSGLGPGDVLHGVDRALDTLGVDTTATAVLARLEQTPEE
VEEGVTRLRWSNAGHPPPAVLTPEGTVDLLLTDDPDLLLGLDPDVRRGEQQVVLRRGSTV
LLFTDGLVERRGEDLDVGLERLRRELASLAVGDPPLDELCDRLLARMVPSVREDDIALVA
VRLHEQDGPPPSRRVQPGPGVEAVELERSPTVSGRIVRTRFPADPASVPGARRFVREALR
GRGAELVDDAELCVGELAANAALHSGGAMMDVSVRLDHGATTVAVTDEGDVPVEALMPRL
VVEPGAAHSEPTTGRGLGIVSVLADDWGVERVPGGTRVWARLVDERVDSVVRPPDSAPGP
EQGPRADAVAGSERVHLRACPVELWLRQDAHIDELVRDLQLLSATHALDPALGSMSEVRD
LLAVFGPVRRAIRRSVEDARSRGLAEVDVVVQLPPSVADDAARLHRLLTATDVSLDEERL
LTVRAEPEVLRLRAWMIAQVRGQTERPDEGEPWPAWLRRTVPG
>A0A8I0LIN7|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MTIEILSPQNSTPNRWLSALLLGCVVFVLTLFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIIIGPALSNIKFALLNLIQAGVGGMLLRALLDRRAPLDS
LHDWARMVLSVGIVTPVLGGLLALWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRTGFSNLRLAEALLTLLLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFISILLAFDLVTVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPHGIWLQVNRSLCQILGYPAEELKRLTFQQITHPDDLSL
DLQHANRLLAGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDGNQEPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMSWDKRMYALFGLAPHESPSYDLWIHL
LHPADREYAALTVQQAIELRSAFHMEYRVVDDQGHRWVRTQANRLLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGWSQEQAAGQ
PLSELLHITQGRNGPEVESLLLCQLPPEKVTPGLAEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHPLRSSDFLARLGGDEFALLMPDCDI
GQAHDVVQRIVAAVNDYRFQWLGRLYQVGASAGVTQISAENCQSSDVLSQADIACYNAKR
SGRGRLVVYEQHRLPLSGNHQGMDAAMIDALQIELPAWAVAPPKTPQAAFIWLLEVQLLT
ADGLLLDETLLRNNLPDETLRRRLDNNILEAFFRHDVQRLNNKGIPVILPLNAQVLSDAA
FVQQLCQRFVAAGLSSSGCGFAFPAASVLSQGDQLYAALLQLRQCGCRIVLQHFGRNLDA
FNLLSDEVVDYLVLAPELVANVHNNLMDEMLLTIIQGQATQRNISVLAGPVSVPALLSTL
ANLDVNGVWGSAVAERQPLRSLAEDHIFAIR
>A0A7X5MPW0|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MTIEILSPQNSTPNRWLSALLLGCVVFVLTLFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIIIGPALSNIKFALLNLIQAGVGGMLLRALLDRRAPLDS
LHDWARMVLSVGIVTPVLGGLLALWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRTGFSNLRLAEALLTLLLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFISILLAFDLVTVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLHIT
DSETRFRHAMEYSAIGMALVAPHGIWLQVNRSLCQILGYPAEELKRLTFQQITHPDDLSL
DLQHANRLLAGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDGNQEPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWIHL
LHPADREYAALTVQQAIELRSAFHMEYRVVDDQGHRWVRTQANRLLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGWSQEQAAGQ
PLSELLHITQGRNGPEVESLLLCQLPPEKVTPGLAEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHPLRSSDFLARLGGDEFALLMPDCDI
GQAHDVVQRIVAAVNDYRFQWLGRLYQVGASAGVTQISAENCQSSDVLSQADIACYNAKR
SGRGRLVVYEQHRLPLSGNHQGMDAAMIDALQIELPAWAVAPPKTPQAAFIWLLEVQLLT
AEGLLLDETLLRNNLPDETLRRRLDNNILEVFFRHDVQRLNNKGIPVILPLNAQVLSDAA
FVQQLCQRFVAAGLSSSGCGFAFPAASVLSQGDQLYAALLQLRQCGCRIVLQHFGRNLDA
FNLLSDEVVDYLVLAPELVANVHNNLMDEMLLTIIQGQATQRNISVLAGPVSVPALLSTL
ANLDVNGVWGSAVAERQPLRSLAEDHIFAIR
>A0A6N3G876|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MLANSLTVKGRYLSFCFGCVVVIGILQGLFSTLVEWVPSFSPLLFPTLTIFLLVFHLFIA
CFMAMKYWCDKRRLYLVAIAFAFAGSALLMIGTLSSFPAWLDLYQFNVVNYNDAMIYYMF
RHLIMAVLFIASALLFPLRNQPLSRLTHIAIVSTTFLFTAGGVMLAWMYSSHFDFLSLDL
VDNETRQFMVLWSHSINISLIVLWVVTLATLMYMTRVRNLFWVTGNFLCVCYIVTLSMLL
LGGHAEDISWYRARLFETVATLLIIFVLLCDVFSLYRESHLKYQQSYQNSIRDPLTRLYN
RSYFYESLNQALDVAKSSRPVSVIVSDLDRFKRINDNYGHLQGDKVLQFVANLLVDSVRP
QDIAARIGGEEFVLMLANTPSDAACQVAERIRLKLSSFDKTTSEGQLPEPITISMGVFTA
TSSSVTAEECVESADKAMYEAKETGRNRVVVFR
>A0A8G1P2Q6|diguanylate cyclase|EC 2.7.7.65|Qipengyuania xiapuensis|TrEMBL
MGVIHQVNGSRGPAYFGLPMLYGIAWLVCAFVALDLTQGADGIAAVWPSSGIFVAALLHF
GPRRRAMTAGWIAAASMAANLWAGSGFFATVGYTIANLLEGYLVFALMGGRARTNMMLSK
PWNMARFGAAAILAGSFSALMAGVLSGNLTLAFLSSWMSTVTLGMLIVTPVILFVAQDPQ
GHRNLVSLRALWTVMVVAILSIAAFGQADIPLLFLPVMAMAIATATLGLSGAAAALVIIA
TLGSLLTAAGTGPVSRFFPVTETQVLFFQLYLVALLISSMPLAFLLAQRGRDLAEIAETA
RLLETAERTAKVGHWRFSPLDNSAHWSREALRICGYDDDAQPSLEDWFDLHHEDDRARVR
SFIVEATSHALPFAFEARIRRTSGEIVHIDCRGEAEADAKGRVVALFGTIMDVSERAETM
RQLEAARARAEREAAEVRNLAETDPLTGMPNRRCILANLAEAMDASEITGEPLSVAMIDI
DHFKRVNDEFGHGVGDKVIKQVADILCDEAKDSDTVGRIGGEEFLFVFPRRRAGDLCVRC
EAIKERILAADWEEPVEITLSIGVAELATGWDERDLMRAADRALYEAKRAGRNQHSVHQS
>A0A1C3JA34|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MNRNNVLGSFLLVVLMSVVLGLYLLYPTYDDDLKHIRPENPSVYSPEKELLLSQYGSTLI
DILDVSRGDPNLASQQLEALQAKFPDQDKAIYRAYELMILSNLAQHKLDTEAVSEYVRQI
KALAQHEHMGWLKAQSLVELAIEYISKGELAESEIQIRAAIDIAESLHYEELLIKAYNTA
GVINNIRNDFPEAQYFFHKGLDLGKKYPHHIYNSKLVSNMALLYIYLEDWPKALELIQKA
KKLYYNSGLLEASTIGVLHVNESFAYLRSGELVKGREAYQSAAKLNGDNVSERYKIILLK
AESDVLLAEKNFESARQVANLCLRYPGVDKYTLQLGQCYLNRALANIGLNRDNFVFADLK
RSHAMFDIVGSRSWKVLGLRTLAEYYDSRGDSENALRYFKLYYKGNKALLFDKRQSDIFL
LEQDFATASLAKENELLNAEKELGELTLDKQQLRNRIVVALGIMVMISATLLLIRLRSIQ
KTNKELLKQSTRCELTSLYNRRYLEQLLTQPMSFNSSQFGISLVILDLDHFKRVNDTFGH
DIGDEVLVEVARRVKQHLSPNDVVARWGGEEFVMLLSGSIEPEQQLNVIRLAISETPIDT
HSGFLNLTTSIGASIGITQEQLNHDTCKKYLKAADDALYQAKESGRNQVIIVEN
>A0A6N3LXW3|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSSIKNKSAEQIKNQTNLPKLPTLGRVLGRIHLIVALVSVATAGIFLTVVALFALRVYAE
HNLHLIARSISYTTEAAVVFGDTVVANEALSMIATNEEVAEAKIMDVNGRVVAQWTLPDD
GPMHQMEQSVARWALPEPVVLPIVHSGNEIGRIVIVGHGGSLLRFLLQGLAGLFVCLILS
TLVAIFLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAYFEGRLSRTLSDCKTNEHVAVLFLDGDRF
KEINDNYGHAAGDAVLTTIADRLRALLRESDLVARLGGDEFAILLAPIYNTDDVLIIANN
IIKSMTQPITLPDGSEIISSLSIGVAIYPDHAQTPDELLQRADEAMYQAKKGFRPCEQGT
AYQSDYIYSENKYPESTHTKI
>A0A5E9HXR2|diguanylate cyclase|EC 2.7.7.65|Carnobacterium divergens|TrEMBL
MLLIGNQIIINLALIVSTVLTCYFVALKFSGNSRIFNQIDLTNTPFWVIFLFGFFIGLSS
LILSNNEIVIFNSFKVDMRYVFIFFSVMYGSIQLGEITTCVVVFGKTLQYLLSGTGGLSF
YLNNILLTFLLLAVCILAKKQQYSWKKSLIVFLSFFIILRIFIFSFVYAPLLQPQKLLNL
FFYFLIFSSIFLITYVIINMAVSVTNTMNHYKARASTDHLTGLYNRRIFSADLSDTYILS
KKSKQAFALGILDIDNFKMINDTYGHQTGDLVLKYLAKQMNEVTQRKDVYIYRVGGEEFA
ILTSLSKKETTQILAEFRQQLITHPFIENELPLPITVSIGMTEFNYLSDTDSYEGSDILY
VRADKALYEAKRAGKDRLVWF
>F8JBV2|diguanylate cyclase|EC 2.7.7.65|Hyphomicrobium sp. (strain MC1)|TrEMBL
MPLNSALKQILLPAICSLTVGIAVFLAVANSTAAFFLLLPTYAVLTAAILLSGGMVLRII
VAAMAAPTFLAIGVGTGQPLVSALAFAFTYSVAIAAACLLLRSQERMPVNLLATIADTRN
AGGAGPSSVCGLVGRKQLIERIDAVSREGHGAIALLSVDIDNFKFVNATLGHGAGDEVLA
IVLDRLRGCVQPGDIVARLSGDEFAIILSDARWRYAVGAAAQSVLEAINAPIKLGQQDLR
IGASIGVASWQENVDIADEFLRRAGVALNVAKAAGRGCFKIFEAQMDAPLRRQQALDQDL
RQALAEQAFEVHYQPVVHLATNEVVAFEALVRWRHATRGLVSPAEFIPVAEELGLIAAIG
DVVLRQACRDAVRWPDDVKVSVNFSRAQFELPNAKSQLEAALAEAGLPACRLQLEITETT
VMANPDRAHVLLDELRALGMEIAMDDFGTGYSSLGCLRNYPFDRLKIDRAFIQDLTTSFE
ARAILTMIVKLANTLGMHTTAEGVETAEQFAIVKEEGCSAMQGFFFSHAVPAHEVLAFFQ
QRIAGSDSAA
>A0A8F9C738|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MASETDRTTDRTTDKAAADQAADSMAGKGARFVERNYRLRIVGLGLGFLCVGSVLLGQQR
GIAMWSLAVFHGIVWPHVARRAALACVVPYRGERLNLMIDSVFGGFWIVAMQFNVLPSVV
ILVMLSMDNIAADGVRFFARGIAAHLAGVAIGAAVLGLTFTPMSTMATIVASLPLLIVYP
ISLGWAMYRMSQKLAARTREFEHLSRTDGLTRLWNRRHWEGQLALEFERCRANGYASCLL
LIDLDHFKKINDTLGHPAGDAVLVAFAGMLRSHFRAGDSIGRYGGEEFGVVLPGATLRET
QAIAKELLLRVREQAREPDALCPCTISAGIAQLTVDMPDYHTWLLEADRSLYQAKAQGRD
RIVVAGGAGAAGAAVAASAAGFVNVKAGVRP
>A0A612C2C6|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MFLKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLLVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A128FAL2|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MLALIHLEEKLPLMHLLRLCRFVCGVVVLALGISQSVALAETDKDTIIVTNSHSWKPFAF
SENGIAKGLLVDYWKLFSEINNTPVEFTLSDWNDSLVAMQEGGRIVHAGLLYSKSRDKYL
DYVFPLFEITTTLYVVNDSEELKTQGVVPGMVIGVVSGGFEEEYLKMRYPLVATMGFDNN
AALIQAARNGKVKRMLVDTQVATYYLLQQENSLGFVPIERMYKKMLYAAVPAGNELLMRE
IESGIKNIPPHEIDRIKQKWLNTSRTTKIPGWLWPFIGSALLLGAASYILLLKQAVNRKT
RALKALNSKLEEYAFTDSLTGLMNRRGLDRVFASKRVKIMLKRGQLGVLMLDVDHFKKIN
DKYGHLKGDEVLNNLSKALNNYLREAVAISRIGGEEICLLLPAEDFHDLKVIADYICSFI
VPQASQDGIGLTVTVSVGALLVDKDGKETSLEALLHHSDRLMYQAKEAGRNRVMLGCLSS
QQHHRYSNPVSV
>A0A128F385|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MRSPKIPDNEVERLHALRALEILDTSQEERFDRVTRVAKRLFGVSISLVSFVDENRQWFK
SAQGLDVKETPREISFCGHAINDDNLFVIPNAKDDKRFCDNPLVTDAPNIRFYAGYPLKL
RPGVHIGTFCLFDIEPREMGEEDRLLLQDLGSMIEQDIKSLQMANLDELTMIPNRRGFLS
LANFSLKLCRRKKLGSSIIVIDLNKFKPINDKYGHHEGDHALKTIAMELFNSFRESDVVG
RLGGDEFVVFLADSTPDIVKHCLSRFTDNMARINRNSNKPYNIEFSFGFGHYDHDNQLSI
EERIMQADNEMYKQKNAR
>A0A378PH87|diguanylate cyclase|EC 2.7.7.65|Legionella steigerwaltii|TrEMBL
MIDDLTLRFATLEHRSKHDGLTGCNTREHLLDVLNTYFQNIQTGGGMCVIMFIDMDNFKL
VNDNFGHDVGDKVLQNFITLLKQRLRKNDLIARYGGDEFIAVMNHISLEEASHIARDIVQ
LASKSYDANEFNVGCSVGISILNRDSVSVIEIIKQADIACYAAKQNITYDSVCIYNGS
>B2U1N0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEACGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAIDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A119A448|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. TAD18|TrEMBL
MIALNNTKHRRSLRSVLSRGHLGLAMVAVTMASVSLTILGVIALKVYADHNLHLIGRSIN
YTVEAAVVFDDSAAATEALALIASTEAVAEAKVFTADGELLAQWKRPETDLLSKVEMLLA
NSLLAQPVTLPILHQGQEVGTVTLRGHGANMLRFLISGLLGILVCTVLSAWSALFLSRRL
LNGITGPLRQLADVAHAARRERAFDRRVPAANIKELNNLGNDFNALLDELESWQSHLKHE
NETLAHQASHDSLTDLPNRAYFEARLARTLRALSKANEKAAVLFLDSDRFKGINDTYGHA
AGDAVLVAVATRIRAQLREEDLVARLGGDEFAILLTPLHKTEDAERIADKIIASMLAPIV
LPDQTQVVTSLSIGVAVYPEHGATPDSLLNAADTAMYQAKRMDRGGQHLAQVQQLASPAN
TRS
>A0A381J8L1|diguanylate cyclase|EC 2.7.7.65|Clostridium putrefaciens|TrEMBL
MNYEHMDIKLLLKSIKAKDEIILELEEKLKESLYYASRDAVTELLNRRAGLSLLEKEIEI
SKINGTSITICFVDIDGFKYINDNFGHTKGDKVLKDVGKTLKESIRKTDILMRIGGDEFV
IVFCNTKIDDANKLWSGIDEQINKLNKETYYNYNISLSYGFSEYSSESPLSIKELLHNAD
KSMYSNKVIYSNKKSN
>A0A1A8TSL1|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MSAVNNPFELAFINMPTPAFIIESKTGKLNAVNHSFAMLFENFNAAPGDSWVELSEEAKS
VEDWLNLCQQIQNGDIDRCESLLNIGTKQINTQLEFHYMGEYVLACVYDTDHMDLADAEN
TLLKFALTESSAGLWIWETDSDLISCSASIALLLGCSREQTPKSTREWHQMVHPDDVERL
NNTVTEHVIHHQNYYECEYRIRKADGEYIWVKERGRTYTKRPDSSIKKIIGFVEDISPQK
ALEAHLRTQATFDELTGLLNRGAAKTHFRKQLGLAKRQYTPLTMAKIHLDAHNRLADLPM
EIRNLRIQTLARHIYKKIREADVLARVEPDKLLLLLPNTSVKDAMQLLNHIIHPTDKEKA
LLLEGKADPLDYCFGIAAFPEDGEDIEELAQSANDALEASRLEHIKASGQAQ
>A0A8G2AJ06|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MDEISFLTIISSIVTTPFFVLFILLGLSLYLQIASLALILLIPFYLGSGGIVGDVPDDAY
IQLSLQSCLATVFVMGIFSWSYYHRHILENALEKSTRTDPLTGAANRRFFDKFIKLEVLN
SVSFKRSCSLIMLDIDHFKRINDTYGHPTGDRVIRQLSDLCVHSSRKNDLVARLGGEEFA
IVMPETKSSEAEKLAERIRRSVEETTILSDDGQPVKWTVSLGVTELVSESVSREIQVSAF
VEKFIQSADSALYQAKNSGRNQLIVRNLVLG
>A0A380WEN8|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MRSPASRHIRRRAVLRQRDATIVGLEARLDAQAALIREQAASLAHSQKIFDRSSAAARIG
VWQCNLADQALHWTDMVYDLFDLPRGSPLVREEIVKCYTAASAVELHAKRSKGIAERTGF
GLDAEIVTAKGNHRWIRITASVECEDGVAVRIFGMKQDITEEKILADQTRYLAEYDVLTG
LANRSRFQSKLSEVTPDGDDRPSLGALLLVDLDGFKQINDTFGHVAGDECLKEVARRLES
ACASVDLVSRIGGDEFAVLVGPGLDLAAVAELAREIIDKVGRAVDHGGRALKLGASIGIA
LHEECTPSDLLVRADTALYAAKSAGRNTFRIFKAAETAGVRNPRAA
>A0A1V5RFQ7|diguanylate cyclase|EC 2.7.7.65|Candidatus Omnitrophica bacterium ADurb.Bin314|TrEMBL
MEKTPQGLVRRRQGYATELLRRIVVFFTPLRLIQLLSFLLVLICFLGHSQTAWVQNLDNR
VFDIFLKAQGDSPVSPDIVYIGIDRKSLQSVKQFPWPKRYYAAMARILREWGAKTVVFNL
FFSQAGDSQEDNEALLAEFKRSGNIYLPLSFESEGFRNYYYVNQSDSLYAAEARGIGHIN
YTPDPDGVIRRAYPYVKFNRNLLPHLGFRVAYDHLGKSVPPPAECALPLDRNNNLMIRWT
KKWNALSGYYPFADILNGYAAIQKGQTSPIRPEDFKNRICLIGLTASDFKRTPLDAATPG
IGVTGNIINMILTEDFIRIPSSAEAAAGLILVALAAGAVMLSIRGVYAMLAAAALAALWA
LLSFWLFSGANVWFGVVPQILLIALFLLISGVTGKIAERRERMYFLNLAARDELTGLYVM
RYVSTFLVQAMRYAQTFRKPFAVILLDIDDFRKVNDVYGYRMGNIVLKRVAEVIRGAIRT
KGRVVPDVAGRYGDEEFIVLLAGYNLATVTFGIAERIRKSLERIEFRTDKAGDPSFHVTV
SAGVAVLKPGEKNPDKVVQRAREALLKAKASGKNQTAIQNS
>A0A5B9MDG4|diguanylate cyclase|EC 2.7.7.65|Stieleria maiorica|TrEMBL
MTQSQTPFEPHNSPFSTVVPTAGAAPSPNPAGQNATTCVSDLLAKLQIASEAVAESPPER
PEREAENRLAVVRLGIATSLFYALRTKHPATAAHGLRVALFCSSWAEQMGLDGELRDRIE
VAALLHDVGKIGIPDRVLRKPGKLTVDEQLAMDTCPSIGCEILRGCTADPDLLAIIRYCN
TWYDSRRDGETPRGDALPLGARMLAIADAFDAMTTEHVYRPAMSRDRAITELVQSSGTQF
DPNLVHDFSRLLEARPEILQGSMVHRWLQQLRPEDSEAFWTGAANPCIAKTHRAKEVVRR
ETLFNQRLLATLKDGVAFTDAEGNVSQWNVAMERLTDLPAEAMIGKHWSAAALRMRDSDR
DRDDETICPLQECFRTGQAVRRAMIIDAVGTDPVSVHVEVAPVHGEQPGSHGTVIVVHDL
SDREHLERRLDTLHKQTRLDGLTRVANRAHFDTTLEEMVTATVTGGPTFALVICDLDHFK
RINDTFGHPAGDEALKVFANILRTQSRDGDLVARYGGEEFLLLANACDNATGAKCAEALR
QMLESTPIEALGGECITASFGVTEFQSGDSAETVLARADRALLKAKDNGRNRVVQLGLGK
MSEVAESTPRTGWFDWLMGNEEAAATKVDILTPVPVDLVIEKLRGFIADHHAEIVNVDEN
QLSLKVLSGSSQGGRRRIDHKISLHAVLTLSEAQKDELLTEKATPGCSTKVHVEIKPIRN
RDRRRRELNDAVAQLVASFRCYLMGEIISRAE
>A0A3S4Q6G7|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MQLPTIPENELQRLATLRALNVLDTDAEERFDRITRLTRRIFSLPICVVTLVDAERQWFK
SRQGLEVTETPREISFCGHAINQDDIFIVNDALKDPRFSDNPLVTEQPHIRFYAGYPLTI
HRQYRVGTLCLIGTEPREFTAEDIETLTDLGEMVEAELLSIAQNTLDPLTTISNRRGFEL
LAHQALASCRRTESEAALLFFDLDFFKEVNDNFGHLKGDQVLYDFAHILMTAFRESDVIA
RLGGDEFVVLLSFVHSDTVNRVIERFKLLLEQYNQQHPKQHSLATSIGIAHWTPDSEMSL
EDLLDSADKAMYQDKAAHHTGAP
>A0A1J5S886|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLATEEVVQSKQQDSAHMNPQISSSNSPRFAPGPILVFAGFIFATMLTGNMLFVYMRDGV
RLEAQRSIAEVGALKANQINDWLDDHQTDAGMLSGNAHLLNEARLWMREGAHDDARRTQL
LGRFQEFINLLHYQAVVMYDASGHVLLSTGEHVPDAREMAKEARAVAASCQRKFIDLHQY
QEESRAIRLGFMSPLLADGTCFGAIYLVEDPARYLFPLIHYWPNESETAETQLVRKDGDQ
VLFLDQLRYRPEPPLAFRLPLDTQQASAIALRGKQGLLENAQNYRGKSVLAYATTISGTP
WMLISKVDEDEAYRLVNRMERTAGVLVLFVFCLIGTWFWQWRRRVLAEAETAVLNQRVIA
DGLRMEGEKRFRTIFELTSLPMVRNSLTGEFIEVNEAWCKLFGYNREEVLSQHLTWQQLT
HPDDLGPSNSMMKKMLAGEMADYKVEKRYHHKDGKVLWASVQVTLVRNEKGEPEFTIGTI
QDITERKQAEKMINFMAYHDRLTGLPNRALLFDRLSQAMSQAKRDGKSVALLFADLDGFK
AVNDRYGHEAGDNVLKMAAQRFLACVREVDTVARFGGDEFAIILGNLDDPQQARGVAEKV
VRAFAQSMALTDGSECNVGASVGISVYPENGSAMDSLMTAADQAMYESKRIGKNSYTFYQ
AKTSLKDDPIWFRIEDSHLVGVEEIDEQHRNLVYMVNRLNDALKRDDSSETILLMFDELQ
VATKHHFDTESRYMANCDYPERDAHEAEHAQLLNQLQHFKAQFNEGRELLVLQSIKDWLL
GHITYSDKKMATYLAQHGVE
>A0A1J5SS87|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAGNWFQEPVHWNYRGEYQLDEASLSAVDQVAPTGGRFIYRADFEINSDDPLVLDFKNSS
VIGHFRHWIFDREGKQVAMAEGGIQSAASNPFLLRHGRVLQLPPGRYRLVSELSSPFFLA
QPQPYLDDLPHYQQSIKPGNALVLTSLGVLLGLGIYYAILALARRSIVEGTYALFILGNL
IYNGTALLVYPDLFGLHWFYLISLPILFSNCAYVVFVIALLDIGRDSNPYLYRTGRGVLL
LLGMFIVLAAFAPNWSLELDRYGVGLFLSYGLAAGIVRARQGHPLARMYLVAILAFFALG
VVSISMSRLHDVYTIYMEHLGLTAATVEALLLALVLAQQFARLHREKEDALQRLQRSQQI
ARTDTLTGLPNRYVLENELEQLPQQGSLTFIDLDGLKHYNDRFGHERGDELLRRFAQVLN
GRLPRQANLHRLGGDEFAITCREGDLFAIDEIMVAAMDELRRQGFEFAGASFGSVHVHEN
PTKDNLMRIADERMYANKRRRKSDIPVQA
>A0A3P3ZQC9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNDESVVPDTLAEDSLLLQIRALGHLPSPSSTALRLYALIQSEDVDLHKVAEVIKRDVAL
TVRLIRMANRPGGTPGRPVASVEEGLMRIGLKTVAGLAVGLSVIDDAVASSAPDASAYLA
LCRHSLAAAVLAEWMCDRPEIPVSAADLFTCALLARIGQLALLRFYPEPYSVLLRLNKNT
HELLDAEREQLGIDHQAITLALLQEWGFPDPLTEAIRISEAEPELRVGNDRSHVMAQILN
FAWEAAPALISRHTEKINGYLEHGLALLGQSVSTEELPGMVEDIIGHWQEWGSHTPGHDS
SNKDIAPNSGEAESVTTRLLLVGVPLAIRQSWESTFAGRGYGVLNVDSWGAVTTQMTNES
VGFLIIWQDEPHILGEQEKRLFESWTGEEQRAIVVLVPELNAPFAQELLEIGADIVLPCT
VSSPLLGAQLARLEGKLVVARNLEAERSTHRKLLSELVLTTRKLHLQTLTDPLTGLANRR
MAEAFLKRHWFQVERRNLPLGVLIIDLDDFKRINDKFGHDAGDAALRAFATVLKENVRQE
DLAVRLGGDEFLVVCPLAQVSNLEYLRKRLIEVARQLTLETGPLSCSIGFAESDRNTMKS
PSELLKQADEHLMRLKRNRPGKG
>A0A1J5QLB8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLYQQSREDSAGLLRLAVQRMGQHPAALTPICYTVWYEYLAGINPHLATSMDARLREGGT
LADAAIDELYRRHCSEFSAEMQQHMRDASQHVLVNLRQQADEARLRIGEFGGRLEQSASS
LSGQQGVEALHSIISSLQGETAAVASSMRDLGQSLEQSQQAIDDLRRQLDHARAEALVDP
LTGTMNRRGFDIRMDESLGHARRQQAPLSLVVLDIDHFKQVNDSYGHLFGDQVIRGLAQI
LKANVKGRDTVARIGGEEFGLLLPETDVGGARILSEKICHTMALSKIRRVSSNQEIGGIT
VSVGVASLAQDEDQNGLFDRADRAMYASKGNGRNQVTVAHV
>A0A1J5TFV0|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MHPLLNHQLRHYMGADFVVPEGRMRSLFEAISEHYRQLEHLGRFDPLTGVANRRYLAEIM
EAERIRSSRYGSPPSVLMVDVDCFKEINDTHGHQAGDMVLQALCETCRSVLREVDIVGRW
GGDEFVVLLPETSPVLAPKVAERLRRAIGELQLASGNGHPLQFSVSIGCASCAAEDDGMD
IVLGLADGSLYRAKHTGRNRVCVAVR
>A0A1J5TBI1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MGDSHGKLRHELEVAQRALAEAEERCARLHAENLAAMEEFEDTRKQIERVKQEWMAALDV
VEDPIFLHDKDFRILRCNLAYQRYAGIPYAQIIGRHYYEVFPLTHAPLRNCLQRLEKTAV
AGQEEDVEFGAHTFRSRAYTVNDQQGGYLYSVHILDDITERRKAAEALAANEKRFRELVE
TISDWVWEVDEQGRYTYCSPRVKDLLGYEPAELIGKTPFDLMAAGEAARVGDIFGRHIAA
REPLRCLENTNLHKNGQPVVLETSGTPVFDAHGTFKGYRGIDRDITERKRLERELEYQAH
TDVLTGLHNRRHFFELAEQELTRSRRYGKQLSLLMLDVDQFKLLNDTYGHHVGDTVLQKL
SEICTRTLREIDIAGRIGGEEFAILLPETMADHALEVAERLRLAIAGATVQREQGDCPVQ
FTVSIGISSLVATDSQIDELLRRADAALYVAKQAGRNRVRAEEVT
>A0A1J5SQM8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKLSARFYLLMTVIFLSFSLVSWLAFSDMVNEINVLWGKRFAERQVLFDKHRTLSPLIRE
IRLARQMAAEPALIEMALHEEDAAVRRRATKVMERYRFDFRDHSYFAAFARSGNYYFNDS
AGQYSDKQYRYTLSPREKRDYWFYATLKSGVDYQVNLDPDVHLGVVKVWINVLLKNGSEV
LGVIGTGIDLTEFLKESVDINQPGVDTFFVDKSLAIQLSADPRLIDYASIAKTVGERIKI
DALFKNPADIERLRQAAIDLEKHQGGEVSTLWVDYRGEKRLLGMAYLPEVGWYDLTLMDE
RSLQVLRGFTWLPLLLGTIFLMAMLILGFLLHRWVLDPIARLTEATEHIQRGNYDVEPPI
VGRGEISALSRSFWQMVEFVRNTNVELERKVNERTQDLLRLTESDYLTGLLNRRGMTDKL
EKEVARQARQGGAMGLLLLDLDHFKQVNDNYGHAAGDLAICATANVLRSMKRSYDYAGRW
GGEEFMLLLPECNEDEMVAIAERIREAIRNLHIEAGTRNFTFTVSIGVHYPSGPQTLDTM
LQQADKALYAAKDAGRDCVRTSRQRS
>A0A1J5R1B4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAARKIHGYPVLILGGGRGGSALLEMFIEDEHVEVLGIVDPSPDAVGIRLAESRGIPVYS
HVSQALPHCMPYPDCIIYNLTHDDSVAEEVNRVFGNKRVTSGLEAKLFWQIVTNLKRIKG
ELESSQNQLNAIIHHAMDGIVTIDAAGRIIGFNPAAEEIFGYTQAEVAGKSVRRLLPPEM
QTHYRSHVRRFLQSRNKEASGIRGQDLVAMRKCGEQFPMELSASKMEIGTQRFFVAIVRD
VTERKLVEQKIRHTAHHDHLTGLPNRILFIDRLEQGILQAKRSEHRTAILFLDLDGFKRV
NDTLGHGAGDQLLKEVASRLQGVIRESNTVARMGGDEFTLVLNDIGSHVNAATVAQKIID
ALAEQFNLNETGCYIGGSIGISIYPDHATDCDALLRMADEAMYAAKKNGKNTYRFYQHLS
>A0A1W1HIV4|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MTHRLSTIQMEDFLGFAPIGIYQVNAEGKLVMANPEMAWMMGYESSSAIVEQMNDVASQM
FAKDEDAEKFLFQLLEAEQVTGFRCELQRKNGSRFWANSYAKQLQNQDGRPDGFYGFSID
ISRIVRIEEKLHQANKELVRIATLDGLTKIANRRKFDDYLVSEWKRSIRERTHISLVLCD
IDFFKPYNDNYGHQAGDETLRRVAKCIEKNCRRPADLAARYGGEEFVVVLPGTDVAGAAR
VAENLRVAVRNLEIPHEHSHAHSCVTISLGVSSTIPEHLSPPETLIEEADNALYHAKEHG
RDRFFVHE
>A0A0M6Y0Q0|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MAISNALLLLAQAAVYFIVMMSLLRARQVIGIGVFMCALGVMHFLETYLASVFYIELPFG
IVSPGSTVLFSGKLLMILLLYIREDALIVRQPIYGLLIGNFLIVALVMILRNHDTISVTD
GRNPDFAFIDEMGLLMVWGTILLFVDAIAIIVLYERIGNWVGRHLGLRFLICGAAVLTFD
QAGFFLALHYVSGAPWHVFVGGWAAKMVATLVYTALFILYLKYFDNESSWLTNRSFKDVF
QVLTYRERYHKLLEASIRDHLTGTLHRSQYDQNAPKILAKNLQENRPLSLLVIDIDHFKQ
VNDRHGHQAGDEILKMVARLLADNLRSDDHLYRVGGEEFVLLCEKLSVEGATSMAERLRK
AIERFSKIYLPEKVTVSIGLASAPQDGDTMEALFRQADLRLYEAKKQGRNRVFSPVTVD
>A0A1J5TLW2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPNQPAVANRGKVFLATKIYEYLLKVALTLIPSLGIGYLQIYQSPALCTVGHALHYVAIL
VSLLVSGFVAYVTWRCYRYSGEPFLRWLALGFIGFTVVYAPHGLFTGISEQHLELFLLYG
PASRLVMVVLLFIGLLHYGRSEDAQEDRTNPARWWLWLMFFIIIDLVVALIAETGAIRLF
DWRIWTEAGALLVALVGVVIVLVRHRSSPLMMTYALSLAFFAQASVAFLLSGPWNHQWWY
GHVIFAAGFFVLSYGVVRAFHTTGAFSTVYGLEELMERLRVEKNNTEAAMRQLQAANAEL
AWMASTDSLTGASNRRHFLECAGVEAGRARRNGLPISLLALDIDHFKAVNDEYGHQAGDA
VLKTLVEGIAETLRPHDVIGRIGGEEFMVLLPDTSHAAAAVLAERIRSKVEGLDIPIEGE
TLRVTVSIGIAEFGLDGDTQDAVFKAADDRLYRAKHAGRNRVVA
>A0A1J5QF37|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MAAQHLLRDAIPDDNLIRLAPEALECLMPMFLWLSPSGHIRAVGATLRKLLGGADPTGLR
FLEVFHIRRPRHASTMDDVMRLAGTRMHLQLRIRPQTGFRGIAVPLADGQGALVNLSFGI
EVAEAVRAHDLTDADFAPTDLTVEMLYLAEAKSAVMTELHDLNRRLQLAKSEAEEQALTD
TLTGLGNRRKMDTVIDRLILSGVAFGLMHVDLDFFKQVNDTLGHAAGDHVLQCVSRVLRA
ETRTGDTVARVGGDEFVLIFPGLAQTERLATIAERIIQTLAQPFYFEGKACRVSASIGMN
VSTQYDPPQPDRMLSDADRALYASKYGGRSRATAYSPDLDLPDIVPAG
>A0A1J5QZW4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLPLPARARGGSVADQHFETRIFTALEKLLKRIFGELILSQFQDLLFPGSQSPLVQRRRS
LLIISRVRMVAGVFAVLTPIWIPVDLWIFAHPLGLYIGLLRLAATAAFAAVALSFRNAED
IGSAHRALGFLLSIPTVFFLVSQPILAEFTISTQPQQVIAAGYAFLPFVMVAGLSVFPIT
AVEGILLSVPLLIANLVVAFLGYQVLTFASHLGALWLLTLLAVVATLAGMSQLHFMMQLV
SQASHDGLTKAYTRRVGEELLDLQFNLAARTGSTFSLCFIDLDNFKSINDRFGHEEGDNT
LRQVSASLRRTLRRADLLIRWGGEEFLVVMPNTDMAGAVAAVQRMREIGLGNRPDGSRQT
ASVGLAERQADACSDWTVLVEKADHRMYTAKQGGKDRVVGLDDKVIL
>A0A1J5RIL6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNLDARTLLFSLILTNAFMVMGLFVAVSCKEGDGKQDGIAKWAVAILLQTLAWMLIAVRG
SIPDALSIVVANGLLSGSYALMLAAIGEFQQRAISRWKYFSPIALAMLIASVLVNDVHGR
FIWGGMVYIFQLLLISRALLTAPETHTGRAWKLLIGGTVIVIAVLVLRAIVAMTGQTILA
QPGVNDTPHWVQVISFVALMGSSLLGSVGFLLMAKERTDREVLHLAMTDSLTGVPNRRAL
MDYAERALALRSGRSVALLMIDVDHFKRINDTQGHPAGDEVLRQISRLLSKRLRGGDLLG
RYGGEEFCVVAPDTDADGAMKLAESLRATLESAVLMIESGKISVTVSIGVALTAANTERE
LKDILAEADVALYSAKKGGRNRVACFG
>A0A6N3AEQ9|diguanylate cyclase|EC 2.7.7.65|Phytobacter massiliensis|TrEMBL
MMEVFLERMKDEWAQLITETAPDIRVLTAGIAQQHAEMLSREFYRIVLADPHAEEYLTNE
QVEKHLTHSLQLWVQEVLSCPAENIDQAIKTQHRVAEVHSRIGIPVELVEMGFRVLKKLL
FPVINISQLKPEEKLAIYHFAINSIDLSMEVMSRAFSFIESSSGKEDENYRIFSLLENAE
EEKERQIAALLTWEMDIVYKVMLNSDLGNSLPLSQAEFGLWFNHKGRHYFSGIAEVGHIS
RLIKEFDELFWETRMSPRALTNKTLRVQFLLQTRNTQSQIITLLRELFDEVSRHEVGMDV
LTKLLNRRFLPTIFKREIAHANRAHTPLSMLIIDVDKFKEINDTWGHNTGDEILRNVSQA
FYDNVRSSDYVFRYGGDEFLIILTELTEVDTLRIAERIRVRVEKIRIKSPTGENIPLSLS
IGAAMFNGHPDYERLIQSADEALYIAKRRGRNCVELWRDTQ
>A0A1C3HE04|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MQTTSLSDTRKIWPALSIFLLVFALCLLGIVSRPGSFLAIFWPANAVLLAVLVRRPQWAT
RAGWGMAVLGYLAADLLTGSALEKALLLNAANLAGVVVGYLLFMRLSPPARMLQRGASSM
YLFGICLAAAAATGLVGAAASQWLFGRPYLTSLALWFSSEFTNYVTLMPFILVFPADWRH
RLRAACAMLIQRSQWPQAGGKLAVLALLALAAVCSVLIGGPGAVIFPMPVLLWLAMSFSL
FSTMIAVLVYVLWCHLAIDFGLLSTTLDMKVLQNAVSMRLGIALLALGPIAVASMNYARN
ALLRTLEHVANHDALTHVLTRNAFMQRGERVIDQKGELVCVMMLDIDYFKSINDRFGHAG
GDQALMAFTRAIAADLNVNDLFGRMGGEEFAIVSTLGQPQQGLQLAERLRQRIEAESITM
PAGHPLQITVSIGMVTCPGGSGHSLADLLKLADLAVYKAKNAGRNRVATPESYPPNDPSH
TPAV
>A0A2X3JCK9|diguanylate cyclase|EC 2.7.7.65|Listeria fleischmannii subsp. fleischmannii|TrEMBL
MDMWSFFKILSYAFANIAVLVFAYFLLARFMKFQFDEPPTWSIRILSGVLGGFFAFLLMN
FSIVAEGSRTLNLIWVFIVLNAYYFGGTSAFITCLFITFERLLFGDMQVAIVFSIVYLAI
GILQLVIGPFLRKKTNFVQLFIVFALTIVPLSTMGLLIAPNISLKVIIEIAIYILLGTFA
CYYIVTDLTTLGKQMSFFERTSKIDFLTKIENRYMFTAKLEQLFGKELFYLFLLDLNHFK
KINDVYGHDIGDLALKLFAEKLYELYPDCCYRLGGDEFAILIPSHSAFNPEFASRELKKT
IAGIRVELPNKEIIFFSTSIGYMRSDHASSEEKLYRLADKALYADKQT
>A0A1V5K2A4|diguanylate cyclase|EC 2.7.7.65|Candidatus Aminicenantes bacterium ADurb.Bin508|TrEMBL
MIEEDKEILNFVSGKIALAINTRAAWTALEVSEERYRTLTENLPVGIFRSSPGQEGVFLM
ANPAMVRILGYESEREMLGKPVADHYFRSLDRGVYSNELIAGGEIKSREILMARKDGRPI
WASISARAVKDSRGSLLYFDGTLEDITRRKEAEERFRESEERWLFALEGSGDGVWDWDVP
SGKVFCSTQWRRMFYLGEEGCLIAEVELSGRIHPEDFARVQEEKRSHLAGEAPLYSTEYR
LLDGQGNFRWVLARGKVMARDGEGKPLRMVGTHTDITSRKLVEEERSLLILQLKQALGNV
KALSGLLPICASCKKIRDDRGYWQQVEVYIRDHSEADFSHSLCPECMEKLYPGITKGRQS
PPR
>A0A090NJG6|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSIYRTL
LPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAWGR
FDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQGD
LLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLKWL
ATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAESS
MYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVRSI
TDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYLIGRPQPLAD
>A0A2X0YYH6|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MELTLEELNKTIMEMRTKGYLTKALKLADQGLLVALESNNYPYVMDLYYQKILVHHSLGD
TLSMVNLIHDYEAICQNYGTTKDLMHYHLVMSLIYDLVGIREKTVEMTKKSIAYAQELQD
PVMLVRCHNNLCYLEVEKGCTKEALQAGLLAREYNKSLARTMPDLAKLHDIRINNNLADV
YILEGDFKKGKALLDSTLSSTIIHHHKREKVAALFGYGFLFEKQQKLEEAVFYYKQAIDL
ARSYGDKPITKKVMRLLLNVLYQLDWRDEIFDVQREYIDLSEKMSVANLLQQVMNLEFKR
QKEKLEKKAHYDPLTGVLNRHFLDYELQEWLNAAEITQSYVCITVLDVDYFKLFNDTHGH
LFGDMILQLLANSLKDFLQDEDVEIIRYGGDEFILCLRHSQKDYIKTLVHNTHAYLLSLK
LEQEQQSYPLRVSMGACVNNQKNYQYKELFEQADSCLYQAKANGRASCVLYELS
>A0A6N3QH27|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQ
AMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTM
LLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSV
IQVDLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTE
AAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEEAGDYDFEQLQSLADRRLYLAKQ
AGRNRVCASDNA
>A0A378X689|diguanylate cyclase|EC 2.7.7.65|Nocardia africana|TrEMBL
MAAPEPAGAQHRRGRGLFARARVADALSYGGLAAVRMWWREPADYRWLLSTLRNQAALGL
LKFSIGTSALGLSFVVLMLLLSSEGPQNAAGRAVIGLFAVLALLVGLRWYLLPWPSASAS
LAFIALADLGITINGLLVSSRVAMINNTALILTGGYLALFHSAKALAAHAGWSLFSVLLV
TVRLGTSDSDRDVPLAIATTLIMVLAVVLVLPTLQFFYWVLRTNAMSDPLTTLLNRRGLD
YHLPRLFAPGAPICAMIIDLDRFKEVNDTFGHQEGDRVLARTAARLRDTTDPAATIARTG
GEEFTIVGRLDAGAARALAERLRRAIESSGNGALVTASIGVAVFDDSDEADDRLSPELLL
GFADTAMYRAKQRGGNAIVVRELREPLI
>A0A2A2FYZ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. WN033|TrEMBL
MPRLSMEQLSAEWAALNQKFPEQVRQFVRDFCCEHSLDLAQHFYSEMLQDPAASLFLSHD
QVHSRLQGSMQRWIAGLFAASDDEALQRLIAEQKKIGEVHARIDVPVHLVLRGARCLKDR
FVELLDHADSQAEGQRLAAARLLSDTIDLAMEIMSHAYSVSHDRNSRTEEAYRLFAMTQN
IANEKERQRAALLDWENQLMFDQAVGLQAAQLPRIHASEFGLWFRHKGIHAFEGTAEATT
IMEIMEQVDDTLLPLFDEQPEQKVQRLRELRDRVKIIRFSLDHLFEQNNALEAGRDVLTR
LLNRKFLSVVLTKQVSYARDNGTPFAVLALDIDHFKTINDSYGHEAGDRVLQQFASLLIN
SSRAGDYLFRLGGEEFLMLLVDTGADGARRAAEKLRQNVAQETFRLPQEQSLNVTVSIGV
AGFDGHPDYQQLMRRADEALYQAKHSGRNRVVVAQ
>A0A2U3Q598|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium vignae|TrEMBL
MSTAATSFPERNAAEVADLVLAPGTTAPEVQARRARQRRQMYIGQVHGHPIGDEVLRTFA
ISIFANIRPTDSFGRYGGEEFLLLLPGTSGDASRHMLERLRQIVADLDWSAFSPGMHVTI
SAGVVTLHDNDTADTFLARADRALIPPRRKGAIALQRADQFISSGA
>A0A6I2HZL9|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT691|TrEMBL
MKIPEKRASVTPSHPLLRMVSLGLVTFIFTLFSLELTRFGTILAPLWFPTSIMMVAFYRH
AGKMWPAIAAVCSVGNVLASLVLFPFSSLNLVFTAINAIEAVIGALLLRKFLPGYNPLQN
LHDWIRLAFSSAVIPPLIGGILVLILMPGESWAHTFLVWVLSESIGALALVPLGLLYKNH
YLMRHRKPRLLLETLLTLAVTLALSAMAMLWLPWPFTCVIVLLMWSAVRLPRMEAFAVFL
ITIMMVSLMMAAKPVPLNTPQMFAMSNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCKFLGYSQNELRAMTFQQLTWQEDLDSDL
EQLSQLVSGEINTYTMEKRYYTRKGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELEPDLISWDKRMFELYEIPSHIKPTWQLWHNCLL
EEDREQAERTIRNALSARSPFKLEFRIQVKEGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWEQDEAMKQPL
LNVLRITFGDNGPLIENIHSGDMSRTDIEQDVVLHCRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENQLKRLLHTVQETHQRHALVYID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARYI
SGRIIQAINDYHFMWEGRLHRIGASAGITLIDESNDQVSEVMSQADIACYASKNNGRGIV
SVYEMQQDRLHQQRSMMSLDEQWRMIKDNHLVVMARSVASPRIPESSSFWLLSLRLWTSE
GEMVEEPAFRKGLSDPELIHALDRRIYLEFFSRWANNVAARGISVALPLSAVGVASVTLV
DELLEGLKHSGMPARLLHLVIAADALLQAGVQDGLSRLRKAGCKIILSQVGQDLELFEHI
TAGSADYIMLDPDIIGNVHASLMDEMMVTIVQGHAQRLGMKTLAGPTNQVMMMDTLSGIG
VDLIYGDTIAQSQPLELVLNTSYFAIN
>A0A1T1JNX0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. MF4640|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQARKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A0J8VM91|diguanylate cyclase|EC 2.7.7.65|Franconibacter pulveris|TrEMBL
MVLKRTLNPTRFRHPGRVVNLCFAIVLLCSTLLTWREVVVLENAYLAGQRNSLDTIATAL
DRHLQYGVDRLLFYRSAMEEALEAPVITPSQEALAAFFAQRDSEGWLLNVNDKRGVPLRG
VSDDYVEQNPYLNREEERLNQELTAASEFSYLMNSASADPALQRNMFYTSRAGFYLSPAA
QEQEEARIRAHYHRLVNHPYFSAHSKRSNPTRGVRWTHSQSPVDQADRSLTASVPLDHEQ
RWYGVLALDFRVDAVTQFLLESLEEDHEADIVLYDSHFQVIAATKSTTHRGRLLSAEQKT
KLAQMMKKATEGDYRLGARFISWARLSYFDGVLVRVDTLAQSASGEFGKITLVLALLWLL
FTSMLIFSWVVIRRMVHDMYQMQHHLQWRAWYDTLTRLYNRGAFFERAKNAAARCREQNQ
PCAVIQLDLDHFKSVNDRFGHQAGDRVLSHAAGLVSQTLRAEDIAGRVGGEEFCILLPGA
TRDEAERVAERIRTRLNAREILITQNTTLRISGSLGVSGAQEEGTYDFEQLQLVADRRLY
LAKQNGRNGVRARD
>A0A4V5PS51|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum|TrEMBL
MPSTSPEQQAAAEWKLLLMQFPAAVAAQVRELAATHQAELAGYFYEQMLQDEQAMLFLTH
EQVKSRLHGTLQQWIVSLFSSTSDETALLALIAQQKQIGEIHARIKIPIHLVLRGARHLR
ERLFELLCRQPLDTEHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQ
HIGVEQERQRSALLDWENQLMFDLAVGQFAAQLPRLSGSEFGLWFRHKGAHAFQGSRETE
LILQSMQQIDEVLLPLFEKAVAEPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESG
RDVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDRFKQINDEFGHEAGDLVLQQL
ATLLSNHCRGGDYVFRMGGEEFLVLLVDVHQGQALGVAEKLRQQAEKERFRLSGEHDLQL
TVSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVVLARELPG
>A0A1C5Q734|diguanylate cyclase|EC 2.7.7.65|uncultured Faecalibacterium sp|TrEMBL
MNIPEILVANGTGAVLVCFLFLLRVRGESKNSVGSELFCRMLVVTLLAQATETISFLLDG
VPGAASRFWLYLMNTVCTGATVSVGFAWCLYVDFRVYRSTGRLRRRHLLLGAPLLAVLAL
LAANLFGTGWIFTISADNVYHRGPLNSLLYLLLFGYYAESVWQVHKAKRDGVTVEFFSVY
YFVITCAVGTVLQGAFYGMAFGWLSVAIAFVFVDSQLRSLRSYIDELSGLFGRKYMNYCL
ERIHATQEKDVYGIMMDVNCFKEINDTYGHGAGDRAIQEIGHILSGALVANSVAIRISGD
EFMVLIRHGSEEILNKICAAIEQRVQRYNAAAPAGSFQLSFSTGVAKYEGGSVEKFLAEL
DERMYAEKRAFHAARNGHAVPEQGNAPSISE
>A0A4R1P7S7|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum|TrEMBL
MPSTSPEQQAAEWKLLLMQFPAAVAAQVRELATTHQAELAGYFYQQMLQDEQAMLFLTHE
QVKSRLHGTLQQWIVSLFSSTGDETALLALITQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFELLCRQPLDTEHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQH
IGVEQERQRSALLDWENQLMFDLAVGQLAAQLPRLSGSEFGLWFRHKGAHAFQGSWETEL
ILQSMQQIDEVLLPLFEKAVAEPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDHFKQINDEFGHEAGDLVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDVHQGQALGVAEKLRQQAEKERFRLSGEHDLQLT
VSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVVLARELPG
>A0A2S6Q631|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MNRAYLMGWFFAGITAFIWAVYSNVLKIGSLYFTTIHPTVFILQSLIVASLVLLLVSGPG
RLSASTLRNTATWVYGTAQIFNNIFVMAAFTFAMTATSVSLLSRMGIAISAVFALIAGVN
EIKSKWGFYLICLGMIVVAYGAESTNKPVAIFLIFLACVFQVIQTKVSSQHKESNLASGD
LKSELRVTGYVLSITSVTYVVFLLLANYVNLDVLLPKLLPTMDEVLSKESFVLALFTGTF
VIATMKYFEFYATKTIGSTNFLVVVAISPLLTIFVEYLVDFMGILSARDVGTYDAIGCVL
IILGALLKVIHELKVAKHQKKIAPEVQQDTDIIKDTINNTLTCFAGNMEQVSQTLDISIL
EIKEILNDERAVTSELRNKILLNHASNIVGLDPLTGLQNQTSFDLKLQKLEDLEKSIVLF
IDLNKFKPVNDTYGHKAGDAILKGVAVRLEEIMPFPHTVARLGGDEYGAIIYGEDAKRIK
DYVDQIRKSIEQPFVVENIEDEITISASIGSAHYPTDADNGPELKHISDERMYEDKKGRS
ER
>A0A5X6ENM7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Aqua|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7H4S3P3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MFGDSAAAEETLASLGKQGQISQAIVLNGQKQHFAAWRHEPLANKEQVSGLISQWLFPEP
TVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSLHRGIVTA
LQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAKNAQLLRS
SLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLTE
VASRLMAFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNLHNGHSAT
LSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A6G7GY75|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MTKPFNILLVDDNKELGENIRDILEINGYSAERVSLGSDALLPAQNKHFDLALVDIELPD
IKGTELVGKLASISPSTQYIYITGHATLDSTIEAIKQKDVISYEVKPLDIDRMLLTIQQA
KIRIQTETELHKSEERYRRLIEGLQDNYFFFTRDASGVFTYISPSIKNILGYTPEEFHTR
CREYLTDHPVNNDAAQCMTRSVKGIKQPPYEIEMYHKNGATRTLQMQEAPVFDSSKNVIS
IEGIARDITEIKTSQSQLVFLADHDPLTCLFNRRRFKEELELRLLEAQRNHIKGALLFLD
LDNFKYVNDTLGHQHGDELLIKLSCILKERLRQTDILARLGGDEFAVILPNTEEEQAQHI
SKQLVELTRNCLALDSLNPLHITVSIGIAMFPAHGDTAETLLANADMAMYQAKDEGRDRG
CIFSLEHKIHIETQYDWKRRIKIALEQNSFALYLQPIINVKTRKITAYEVLLRLTEKNQE
VVPPLKFLGTAERFGIIHEIDRWVVVNAIRIIKELKLHENGIFLEINLSGKAFSDNELLS
IIKREIGENILRPEMLIFEITETAIIENIAKAQHFIATLKSIGCRFALDDFGSGFSSFNY
LKHLPVDYLKIDGSFIQHLSQNSVDQHLVKGMVEAARGLKKLTIAEFVETKETFQLLKEI
GIDYAQGHYFGKPLSVCDALQQFNF
>A0A7H4MN72|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MDKPLRLKINKLRHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTL
PVFGVSGSVVGNNPMLLKEDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMTHYSQAISALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLSVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVL
PNTTLQDAVAVAERLRLRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADR
RLYLAKQNGRNQVCFRSEA
>A0A379J001|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MLSVPIPPNEAERQQALDRLELLDTPADPYLDTLTRLAHDLFQVKLALVTLVDRDRQWFK
SRQGLDVAETARSLSYCSHVVLHDEPLIVEDSQIDQRFAGTELALNTPDVRFYAGWPLRD
VNGMPLGTLCVADPKPRQFGHQDRFKLRDLAYLTENYLHLQHCSQQASDLRDALSREQRK
GMLDVLTQLWNRAGLLHFLPLEQAAAERHQLRLGLIYCDLDHFKQVNDTHGHDGGDHVLW
ESARRMSAAVRPQDVVTRNGGEEFVILCQVHDEQELLQIAERIRLAIASQPMQLENAELQ
QTTSLGCTLLGPGENAVDGLKRADQALYRAKRGGRNRSELAPSAH
>A0A8E5TVU9|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. SJTUF15034|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>W9UYJ3|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MSLTPHLLDRLASLTSIRDLELLEFSMLKTVHELFRPEQVMMLKYDSDGEVRFTLRYGHN
GNYDSQTLRKKLIDEPEVLSALHISRRLKTTYHSKKANGNHISIYPVLDLQLLSVALVVE
SRRINSQNDSRVIHALLQIYRNFCQLIEDSQRDQLTGLLNRKTFDDSIQRVIGMSSERFP
SFGDDDRRASVEGEPVYSLGLIDIDNFKQINDTLGHIYGDEVLLLMSQIMRHTFRESDLI
FRFGGEEFVVITETDSTDTAMVAFERFRAAIDEYAFPQVSHVTVSIGVVEVNSMDVVHTL
LDRADKALYYAKNHGKNRVCSYKELLERGAVKEPTYSSGDIELF
>A0A1Y3C6B4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 3903|TrEMBL
MNTESIAVLAAQWKSVCQDFSITDLNDTFQFIQAHSQTLVYEFYKNIMQEKEASYFLSDD
IVQNRLKTTLNQWLIDCFQVPFQQNFTEIVEKQLMVGKVHARIGIPSWLIMRGVGEIEKK
VFLLQTGQVQKNSLCMASYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAA
QKDKQRSSLLNWENELMFKVFSHEPKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVTAIVD
RIYQIDPLSQQVLNAAKKDKAIQLIQDIRDKNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLSTIVSREINFSRKNNAPLSLLAIDADHFKRINDKFGHAAGDSALQFIAEVLHDSI
KGSDYAFRIGGEEFLLLLVDSDLIRAKELAEQIRSRIQETTIGTRPGSSFNFTVSIGCAL
YDGHPDYQRFLDAADTALYAAKNSGRNRVYVAQTELQASTMTVQS
>A0A1V2N369|diguanylate cyclase|EC 2.7.7.65|Wolbachia pipientis wVitA|TrEMBL
MTAKILVVDDVLSNVKLLEARLKAEYYTVIVAHDGEEAIDLVAKQQPDIILLDIMMPKMN
GFQVCKELKSDPLTTHIPIIMVTALHDTHDRVQGINAGADDFLTKPINETALSARIKSLT
RLKMIIDELRLRGETNAEIGGVAGNSIMDYSNQIFDANILVIDEDVHQAEQIYNILKQRF
RSIKILSDPMEALKVGIENGYDLIISDMQFSKTDGLRLCSEFRSKVETRYTPILILSEDY
DKNNLVKALDVGANDYLTVPLDEGELIARVNSQVKRKRYQDALRMNLFNNAEMSIKDPLT
NCYNRRYFDAHLRNIVKDSVEKDRRLSLMILDIDYFKIVNDSFGHSAGDELLKQIQKRIS
ENIRVTDLLARFGGEEFVVVMPDTNVSDAYTIAERIRKIIAKEPFVLADKNTTHNVTVSI
GIAEMQGSDFDDIKKFIVRADRYLYKAKNSGRNRVVTGYS
>A0A1V5I9N4|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.BinA166|TrEMBL
MSTRNQFPGNSWRAARLQIREEADQGLLEHLAFQERCFSVFPIPMFIKDRRSVYVFVNEA
FADFLALPPDQVLGRGPFDLFSPEFASKIIEQDQAVMTSGRSSVDFEAPFRTGRGELVWL
KSYKSPVFNDRDEVIGLMGGDMDITASKRAEEERKRNEERWKFAVDGAGDGVCDWNIETG
EVFYSSQWKALLGYRDDEIEPSFAELESRIHPEDLQEMNRRLEEHLHGLSPSFSHEFRLR
TKSGAWIWVLNRAKIFEWKDDGSPFKMIGVFTDITRRKSAEEMILHQATHDMLTGLPNRL
LFNERLYAAICDAIRLGGMSALFFMDLDNFKAINDTMGHSMGDLVLMAVAERLSGETRAA
DTLARLGGDEFAIVMPLIAGRDDAAAAANRMLDALRREIVIDGRSISISGSMGIALCPDD
GEDLDTLMKKADIAMYRVKREGRNAWGFSE
>W9UPU7|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MRKEFEVESHKLANSIDDARKRSILLFVSYITGSVMLVYGILHLFNHNHLLLLILFGCSA
VFYGNVLFYHLTRRLNEACEFESILVGTFVLALVYQGGHENTALYWVFPFPAILFGLLGV
RKALVMNIILLILLSVMLYVPGFIEAQYADAEKSRFLVSLSLVIIVSLINDFFRERSHMA
MSQVQQSREKQANTDVLTRLVNRRFITVSLPKYLNQNPENFLPLAVIMCDLDHFKKLNDS
YGHECGDLALKHVAQLFLDHLRQQDIACRSGGEEFLFLLPLCGVMDALHVAEKIRAALVE
TEFSYQGQPIPLTASFGVSLCKVSNGLDEAIKVADLKMYEAKQAGRNCVR
>E2XIE8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFR
RCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREI
RATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVDD
VWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPT
KQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPY
YGNSASVKLLTPTQDSRDIINAATRSLDAIWQVGHRYQKAGVMLGDFFSQGVAQLNLFDD
NAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRVK
>A0A7U7GG00|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MISSGLIPLEQGQVIPSRDQLLEEIAALRRIVANRDNTLLSLTRRMDRVIEEVRAERDRL
DKVVKREQKLSELVRRVLASMRDALIVTDPEGVIVQANAATYRELGYGPDALLGIMVDVL
LPPEVLAAYERALPVRRVVSASVWVETIAGRRSYLEEHELLNRAGRVAGIFRVGAEIFHS
AQGKFEGVVITASNFTQRIAVEQALVESETRLQSMLDGSPIPLFVIDLEHRITHWNQACE
AMTGMPAAEMIGTRNHWRPFYDSPRPCLVDVVLEGADSSEVMRYYGSSVRDQGLSGRILE
GEGYFPRLGKSIFFTATSIRDSQGKIVAAMESVQDFTQRKEAERALAESETRLRNILDGS
PIPLFVIDGNHRLTHWNRACEVMTGVSAERMMGTRDYWQPFYDSPRPCLIDMVLEGVDPK
EIERYYGASVHNRILSELVYEGEGYYPTVQKWLSFTAAPIRDSQGHIVAAMETVQDITER
KEAEEALRRSETRFRSLFEEVPSVAIQGYGPDGTIRYWNKASENLYGYTAGEVIGQGLLE
LIVPPKMRERAFDAIRSIVTSRKSRPAEELQLMRKDGSLVTVLSSHAVIPTLDSKSEVEF
YRLDVDLSELKRAQERLRLAASVFEHAHEGIMITDAAGTIIDVNKTFVEITGYSREEVIG
HNPRLLKSGRHDAAFYAHLWQIIAEHGYWHGEIWNRRKSGQVYPEITSISAVHNAKGVII
HYVGLFADISVLKESQQRLEKMAYYDPLTRLPNRALLADRLQLALSKAQREQRILAACYL
DLDGFKPINDTWGHAAGDDLLIQVAQRLQSCVRDNDTVARLGGDEFVVLLDDLHTLDEGE
RALQRILEALSAPFALGAATVTVSASVGAAFFPSDGTDPDTLLRHADQAMYSAKQGGRNC
YHLFDSEHNRRAQTHRELLERVGQGLVAGEFCLYYQPKVDIRCGKVIGAEALIRWRHPEQ
GILPPDAFIAVVENSDLAQTVGDWVLGTAMKQMAVWAAEGLTLPVSVNISARHLQQPDFA
ARVQALLAHHSSIQPEWLELEILETTALDEIEQFSRIIADCRQLGVRFALDDFGTGYCSL
TYLRHLPAQILKIDQSFIRNMLDSPDDLAIVRGVIGLSSAFKRDIIAEGVETIEHGVLLL
QLGCDYAQGYAIARPMPAEEVPGWVRAWRNPEEWNGSRRHSR
>A0A2G4AWI0|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MNKNNVLGSFLLVVTMSAVLGLYLLYPLNDVDLSPPQADNTSVYTPEKELSQTEYGKKLI
HILGLSRSDPSVAKHQLDLLRPPNGVNDKAIYQAYRLMILSNVAQHQRDADAVMAYVEQI
KALSEHEGMLWLKSESLVESAIEYLKKGELAIAEIEIRSAIGIAESIRYDKLLVKAYNTA
GAINNVRNDLQDAQYFFYKGLQLGKHYPTHIYNSKLMSNMALLYIYLEDWPKALRIIEKA
KKLYFKSGLIEDDAIGILYINESFLHLSSGDVTNGRIAYEKAKALDSKRVSVRYKILLLR
TYSDVLLSEGNFSKALQVANQCLQAPNIKKYTLQNGQCYLNRALANIGLDQDDAILNDLE
RALAIFDVVGSRSWKVLGLKTLAEYYESQGDLDTALSYYKQYYHGNKALLFDKRQSDIFL
LEQDYAKQTLANENELLNTEKDLNELLLQKEQLRNRIVVALIIMVSISAVLLAIRLRSIQ
SKNKALVTQSTTCALTGLYNRRYLEQLLTQPMPFNTSRFGISLVILDLDHFKRVNDTFGH
DIGDEVLVEVARRVKQHLFPNDVVARWGGEEFVMLLSGSIDPEQQLNVIRLAISETPIDT
HSGSLDLTTSIGASIGIAHEQLNQDTYKKYLKAADDALYQAKESGRNQVIIAES
>A0A7Z9BKM5|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MAEEIRCCPYSKESLCEQLRIQVQQLEIQLQQERQKRQDLEQIVRTYEQDQKNVETPNET
GEIIGGMVVNQDITERQQVEQELQRVKERFELAITASNDGFWDWDFVTGEIHFSPGWKEM
IGYEDEELPNLLSSWEQVIFEEDRIAALQLIEDYNSGRVDRFLTTQRFHHKNGSTVYILS
RAIHCKDDQGRVIRMIGTHTDITELVTAQAELQRKTEILQMIIDHIPIMLAFYNSQGEIE
FINRELEQVLGWSITEIQQMNLLDACYPDPDYHQQVIDFMLSPTGEWKDLKTLTRQGELL
DTAWANIRLSNGMQIGIGQDITERKKAELAIKQQIKRERLTQKITTKIRQSLNLDEILQT
TVDEIRELLNCDRVLCLRFSGNKTSTVVIESLNPGWPSVLNETFVEYDFPQEYYQRYCQG
YPRIIPDITQDILVPCLVNYLQTLGIKSKLIVPLLKENILWGLLIVHQCSHQRNWQQSEV
NIILSLASQVSIAIQQSQLYHQLEEANHELHRLAMVDGLTQVANRRYFDTYLLTEWKRLA
REKLPLSLILCDVDFFKLYNDNYGHLQGDECLKQLANILAKLAKRPADLVARYGGEEFAI
ILPNTDQFGALTVAEFIQEELAQVKIIHPNSPHRYVTLSQGITTCIPLPDTNFDLLIKKA
DDALYEAKAKGRNRAIFYQTEFTTN
>A0A7U7GGX7|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MQPVDGYSIREMIYESSHSQVFRGWRTSDALPVVIKTPSSSSFSVRENLRYQNEYNLLAA
LNLSRIVKMHDLVQYRSGFAIIEEDYGAGDLDQWLGENRMALPEFLPVAIQMAEGLDQMH
GQRIIHKDLNPANVLIHPETALVKLTDFGLSTLIGVETQEACTPELIEGTLPYVSPEQTG
RMNRAIDYRTDFYSLGVCYYRMLTGTLPFVTTDPLEMVHCHIARPPVAPAVLNAAIPPVL
SELVMKLLEKKAEDRYQSAYGVMQDLIALQAAASSGEPLPKLELGRCDVSRYFQVAHRLY
GRHRETRRLLDAFDRITVGRSELLLVGGYSGIGKTSLVNEVQKSLVLKRGFFIAGKHDQF
QRDIPFSALIQAFRRLVSQMLSEREEQIQHWRETLMAALGSNARVIIDVIPDVEWIIGPQ
PPAPELGSAEAQHRFSRSFQQFIGVFARPEHPLVVFLDDLQWVDAASLALMELLCANPDS
RNLLMIGAYRDNEVSASHPLALTLNHIRDELASVETILLGPLEPDDLNQMIADTLHQPSA
ATHPLTRLLLEKTGGNPFFVAQFLKELHDQGWFRLDPANGRWQWDMAQIEAAGITDNVVD
LMAGKICRMSPLTRQALQIAACIGNRFALTVLAAIQDRTEIATGSDLWEAIQEGLVVTAK
TEFRFLHDRVQQAAYSLIAPADIGPLHLKIGRQLWYRASPAELDEHLFDITGHLNAVLAL
IDDPDERFQCSLLNLQAGRKAKAATAYEPALRHFQVAAELLAADCWTAHYRHTLEIYRER
ADAAYLLGQFAAAEADLNEALAHAADRYDQADIYLQKIIQYNQLGKYNDLVEVARTALRL
FGVTLPDANDEAGLAADFGQQMAEYSRLLNQRPMGDLIELADIADREQDGIIRLMAILTD
GTYIAVPSLFPHIVMEVVNRSMRYGHNAMSAIGFAWATVLIVRQFGNYQDAYALGALAMR
LNERYPNPRIRAQVTFLYAVCALHWVQPLAEQIEVYQQAYQYGIENGNLVFAGYARTMIP
KTTLAALTVDKALEECAISLAFYAKSGSPFLMSERFCQLFLQRLKGKGRDLTSLSTDEID
ETAWLERWQHPATRFGHGLAYFLNFKIQLLYLFGQWRAAWDFATAHADWMQYIPILYETT
VFTFYRALAGASVHEPADAAEQVRIASTLGEAIADFTVWTANCPDNFAWQEQLLRAEQAR
MSQRPADALAGYVRAAALARRYHRPLGLALSLERAGRLHLQQDQRKRAKPELEEAVFHYY
QWGATGKAQALNQEFAGLLTSAAVARLPVSASSSGQSTSALSTHRLDLDTVLKASLALSS
EIQIDGLLQKLMAIVIENAGAERGYLLLPDMDHWLIVAQASVLDRNAQLKQIPLADSTMV
CESAIRYVIRTRQDLTLDDAGQDSAFCRDPYVQRQGVRSVFCLPLLAQNRLNGVLYLENN
QLAGAFAPGRIQILKMLSAQAAIAIENARLYESLERQVAERTHELSEANRQLQQLSEYDG
LTGIANRRKFDAVWNTEWTRAIRQGLPLAVAMIDVDHFKTYNDHYGHQAGDDCLRQVAQA
LAVTVQRVNDLVARYGGEEFVVVLPGLTAPEALEVAQKLGAAVAACQIPHAHNSAASVVT
VSIGVAWRIPEPDASPNDLIVEADTRLYQAKHAGRNRVAPAP
>F5NQD0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRYNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A5P9C8B9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSPSTPRGTQRSLQSLLLKRFAMAFSTYVMMALVCWFAVFNGLFIGSVSTAAWLTLGVMG
SQLVFLWLFLSGRNLRFDDPSLTEAQVLVALAWQPPVLAFFDTARGVLMVFYVLILLFGV
FQLPPRVFVRCALFAFFGFTAMVLIEAYRMLLVDPSMAWLQVWVLFILLVWLCLFSSYVQ
AMRKRVRQRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRLAARELENMGPGR
QHGLALIDLDHFKRINDAHGHAAGDRVLQTFAAVARACLRDGDVIARYGGEEFVLLLPNT
DADQFTACCERLREAFASAEPVGVVVDNLSLSAGMTLLLAGDELDEALQRADQALYQAKR
GGRNRCDASWERAGA
>A0A755GMW6|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi A|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAAEVRDKNGRTIASWRYDARAADDKLIGLISHWLFPLPVSQPVWHNGRAIGEVRLVA
RDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLHNGVVDALQNITEIVHDVRTNRNFSR
RVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSCI
NALMKDNSARSSSALLFLDGDNFKYINDTWGHAAGDRVLIEVAKRLAEFGGSRYQTYRLG
GDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELHNGQRITMTLSIGFALTWEHATAEKL
QELADRNMYQAKHRRAERSLN
>A0A143QLW7|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MVIDSRRRVLSSLLAVQLVLYSAAFIASWADTNGAGAVGEMWAAVVAAVGSVAILSRRPG
PVRQGIAIACAALAPALTMLTHQNLAAQVWALIPAMFLALYLRATYPVVVARVLCVALAL
LSATALLLAPAPAPMLWGALYVVCILAAAEVFGALGAALIAGALRDPLTGVFNRAGAVDA
ATNLAARAARRSENIAAIVFDVDHFKAVNDRDGHAAGDRILIGLADALTEKVPAGSVIAR
LGGDEFIVLVAGLDTAQIDTLAQELVDGHVVSVTYGIAVGSPGPDVLEALTQVADADMYR
RKMLRRRR
>A0A2G4B1U6|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MEQQFLLEGHRAVNSLLRKLALGMDRKDLNHKIIQLTEQIFGQRMASILLLNSESKTLHL
EYAPNLPDFYNQQIEGVGIGAGIGSCGEAAALKKAVMVSNINAHPNWAPFLALTNQANLH
ACWSVPIISSRGNVLGTFAIYSQYISEPHEFELEILELLASLYSVALEKFELENQLNFFA
NRDSLTHCLNRRALFNEAEKVLAKRCFSEKVMACLFVDVDKFKSINDTYGHSFGDDVLLA
VAEVLDEATTACAKIGRYGGDEFVVFSCFDDQESVVSFYHSLEKALQQALYINDVQFSVS
VGLSCDKDPQGLDQLIAQADKNMYQIKQAKSQR
>A0A5P9CBI2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MKSAHWQADLQQVQQLRLFHNVAASSLDQLLREFRACELEAGEVLLSPFNRNQHLYLLIS
GQLRVYLGSLDNQAVSTLEVGDCAGEISFIDNEHPSAYVVAERPSVVLRLHRESLIALFQ
QSPQLMQNLLELLCERVRQGNRQILDSEQNANIDTLTGCFNRRWLEHVFERESTRCAFND
EPMSLLMLDVDHFKAYNDQHGHLAGDYALCLVAHTLRNQLRPKDSLIRFGGEEFVILLPE
IADQDARTIGERLRASLEQIDSFYSPVGVLPGVTISIGLAQMRHSDSLSGLIARADAALY
QAKQQGRNCLCG
>A0A5P9C2S2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MLQRFVLSLALLLWLASTSQAAPVITLSATSSGSALNADVELLEDSHGTLNIGDITSAAQ
QSRFQAANGRASVGQSLNPWWIKLSVQRDSSAPTDWVLEVGSVTQLDLQLYLPDGQGGWQ
MRQAGERVAFSESRDLAYRRMVFDLPALGEQPLTLYLRAFDPAGNSFPLRIWQSDDLTQL
AIRENLGLGVIYGVVFALLLYNLFILISLRDKAYFWYVLTTAFALLFIISMTGHGAQYLW
PNHPVPVWLDRITLPSLWGLFASRFTQTLLQTKLYVRWAHHLLNMACVIYLIAIGLTLFE
QRYLAAWAIALLSLTSIPAALGSAVIRWRQGFFPAQLYLYGYGLVLGSVAILLLRTTGVL
QPAEWNAYVFPLAVAAESILFSFALAYRIQILKQERADALLQADREKTARLAQLQASADE
LQAAVTARTAELAATNDQLREREHELQHAAFHDPLTELPNRRYLVERCESALAHAERHQE
SVALLLIDLDHFKPINDRFGHAAGDLMLQVIAKRLREHVRAGDAVSRLGGDEFAALICGS
DAENQAREIAARLVSELSVPVHYGAERLRVTVSIGAALYPCHAQSFTGLYKAADAALYRV
KELGRSGSRIHGDDGELSEQACLQLDVLKVPSGLA
>A0A8B3W883|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLQFVEYSESAELAMSSINFESTYGVITIQDMNVVSVDANYARIYGYQSPEELLTNIDSF
LDLISEEYHVLAYQNYLETISGQRDPQVHTYVNVDRNDREFTVFSIDHVTEWQGRPALQV
TVIDLSPAIQLQNAVREQDKMYHDMIMQSGQGILVHREFKPLMVNQSWVKMQGGSSIEQV
LKLDSILTLVPKQNTDGISKHYQAIVSGELSGTSTVVENIGFDGIHRFFNIYDNAITWQG
QPAVQVVLEDVTQKVMLEKQLVHQANYDEMTDLLNRRAIYEWLREHIASDTHVVSMLLDI
DDFKSINDTYGHMVGDEVICALANITKRNVERVGGVAGRWGGEEFILFIPNASPNVSREV
SDQIRQQFNQVEFKVGEQIRFNVSVSIGVSDSRSCEGKVSIDALVNLTDQSLYRAKANGK
NCVCGEVFANDISQALPH
>A0A0H3MJP3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O7:K1 (strain IAI39 / ExPEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A174U1A0|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKSIQTKFIILILSCVFVCSAVIGGAGIISAERVVDEDSAQMMNYRCSQLACEVDAMLSR
IEQSVKTLAVYTDENLESVELLKSDGTRKAFTEQIESVAVNAANNTEGAVAVYVRYNPDF
TPPTSGVFWSKTNLNGTFQKLVPTDFSRYSPTDVEHVGWYYIPVKNGRAIWLSPYTNENI
NIQMISYVIPIYKNNETVGVVGMDIDFSVIKDMINSLRIYESGNAFLTDDKGNVMYHNVY
PFGVPMGSVDKSLIPLVAELENGTSGSSLFSYVNENVERKLAFRTLRNGMRLAVTAPLSE
IDKNKNMLLMQIVTALLVIAPLSVLVTVLITRRMIRPLKELNEAAKQIAKGDLSISLTQQ
TKDEVGTLADSFQQTVNHLQKYINYINSLAYRDALTGVKNKTAYQEAERRLEEQMRNGRP
EFAVIVLDINNLKKINDHYGHDFGDMFIVDACRLICKSFPHSPVYRIGGDEFVVILEGAD
YANCTHLLESFHDAIEEYNRSDQQDKHLSIARGIAVYNSVTDLVFSNVFKRADDAMYHNK
ADMKRKRVAAEAEENGEITTEKN
>A0A383RQQ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas reidholzensis|TrEMBL
MIDNRSGKGLSFVRRIYLPRIIGMGIGLFSVMAALAPLQPPTWVWLLLVCNGLAWPHLAY
HWALRCATPYHAEQRNLLIDSLMGGFWTAAIHFNPLPSVTLLSMMTLNNVAAGGKRLLVR
GLLAQLAGMLLASLVLGTGLQLQASPLQVYACLPMLTLYPLALGWVCYRLAIKLAEHKRQ
LSALSRTDSLSGLLNHGAWKDLLLLKFQICRQQQLPAVIALIDIDHFKAINDTFGHVVGD
SVLRHLSQELQRNLGQDDQAGRYGGDEFCVIFPGQGQGQACQAMENLRERVSAYRNPQLP
ALRISLSIGLSAFDKGLKSPEHWLDQADKALYAAKHQGRDQVNFTRGGAAPLRLAYPD
>A0A649YY04|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MVKNETLQTRQSDAILDIRQQKQVLKFIAAITLIFFVPLGIKNLLIGETMLGAVLLAFEI
TLLLEIAAIIYNKVGLFGHFIPLALLVTSIIMAVNIFGTLATYWVFPIIISIVFLLPART
ATIANIVVCLGCTIAVLPHQELSETSRYAFSLLATAVIVHVVVKAVRQLQTDLRYLLVRD
PMTGAYNRHQLQSSLENIRQLYTTSSIALIDIDKFKTINDLYGHDVGDQVITQVVKIIDA
ETEHSTMLFRLGGDEFLLLFPQADQYAVESSMEAINRAVKESDYPQEAKVTLSSGVAESQ
PFETIEDWVKRADIALYQSKSLGRDRVSLFSQPDRVDNDNQSTYQRASR
>A0A6N8HKP0|diguanylate cyclase|EC 2.7.7.65|Lentibacillus sp. JNUCC-1|TrEMBL
MTCDICNPKPRGYTIYFSEDQHTEQLTHYFKGFPETEWTLINNRMFWTVEPVFFGLMDYI
EAHLSADDIFAVEASREDPIRTLNALQPIRSFQETRAFSWIDGLIQNRRIQTYYQPIVAV
KNNVIQIVGNELLSRGVNEHNEMIPPFKMFEAARKRNRLFALDRVCRMESINNAKNATER
LIFINFIPTAIYVPEHCLATTFALIKKLDIRPEQVVFEVVETDKVQDIEHLKSILSYYRK
HGFKYALDDVGTGFNGPELIADLQPDFVKLALEYTNGVSKDAEKKATAEVVLKMAHDVGA
QALAEGVERKEDLDFLNEMGYDLYQGYYFAKPGPEPLQDIKIS
>A0A2X2DCQ4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas luteola|TrEMBL
MLMVSQAFAQARPVLLTDRNNFLDLAPAIEYLPAPVTMDFEEAASERRQEEWRPNTRTTL
NLGSEPQGAWVRFRIRKDTHFNQAWLLVFDWPMLDQVDVRIHDEDTNSWSKVLTAGDTVS
LSKWPIPARELVFPLDLENSKRVTVYARIRASEHMILPLQLVTEKAFQQDQVWDTLLLGA
LYGSLLVMLLYNASLFIFTRDKSYLWYVTYLASSLWYVLCLSGHGFVYIWGEWSTISGRF
FQLSACTTFLSSAIFVRVFLNVPRYQRLTIINNLVITYWGVATTVALLFPDNIRYLFPDI
LGFVSCVLALTVTVSIWRKKNPSARYFTIAWLWLILATIYITLCLEGVLPLSRFSYYTQF
SGFVFEFLLLSIALAERINRERAQRLISQKIALDASEEVAQKRLQIVHVQEELLKTQRRA
NEDLERRVLQRTQELETANRKLVQLSNTDPLTKLYNRRHLDEIFAQQVITAAAQEAYLTI
MMLDIDHFKHINDTYGHTIGDECIAALGEGLKCLTRRQGEYAARFGGEEFILLFTTLTPS
TAPVVAEEVRLMASNLGIQVESHTVQFTVSIGVVCRLARLGQTRVSLSKAADDALYLAKQ
AGRN
>A0A517S7W8|diguanylate cyclase|EC 2.7.7.65|Caulifigura coniformis|TrEMBL
MQFDPAVTAKLLRAASSVGMGVAQPVTDLRRALNILGIKKVTSLALCFSLCEGSMTPGPF
SKLYRKVWLRAVVQAQASGDLAAMIAPGRQAEFFSAGLLSEIGPLAILKTRPNEFPEFLA
GEEADPTNYASGSELSAAILAHWQMPESFSEAVRNRWRSLEELTHLPVESDLLLSHAAAL
SAATAEYFCQPQKGMALVRIHELADVLFGLKQDAVQSFVERVQGHVMENCDLLETDISTW
GQPSEILAVAMEQLSQLAVTTLESTIEQGLAQQVNQENQRLRRRVEDLLHRSITDVLTRL
FNRAHFDDQLPQWIRNARGCQGTVGLLFLDLDRFKSINDTHGHAVGDMVLKQVASAVKRT
TRESDFVARYGGEELVILVANPTIGSLQGLGERIRAEVASELVTTATGVVRPTVSVGGSI
VDPVHSLEAASELVHSADQAMYLAKRNGRNRVEVWSVLPHGHQESAVAEEMGWPMFSSN
>I6CQJ0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIA
HANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEF
IIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIA
DEALYIAKRRGRNRVELWKASL
>A0A7S7C181|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MNQCDTVVSSASSEAQRLARLALLQVVDTAAEPFFDALAAAAQAIAGTPIALVSLVDERR
QWWKANIGLPGVSETPRELAFCTYTIQGDAVMEVRDAPADPRFHDNALVTDAPGIRYYAG
APIVLPDGLRMGTVCVIDQRPRALEPAQLQALQQLAKVAAEGLEQRRVMLEREAANAQLQ
QRLRESEAFLERTGRVAGVGGWEVDVASGTLIWSDQTCRLHDVPPGYRPSLTEAIGFYPL
EARAVITEAVDACVRDGTSWDLELPLTSATGRRLWVHSTGSVEHVDGRKRLIGAVQDVTD
RHRAVDALAASERKFRKMFQYSLGLICTHDMHGRLVSINPAAARSLGRSVEQMEGRSLVE
FVRPERHAALRGYLSRMVLDGQDSGVIELVAGDGSLRHWQYHNVLDVESDATVVLAHAQD
ITNQYRQEKQLLEWSFTDPLTNCYNRRFLDELDKRDPAVRWGCIVVDLDKFKLVNDTHGH
QRGDEVLVQMAWFLNQPLRTQDRLVRLGGDEFLVLLHQASQTQLDALKRDYMGASEDAPI
RFTLGTALRQDGEALAAVVDRADHSLYSLRRARRGTGTSDQR
>A0A517SE21|diguanylate cyclase|EC 2.7.7.65|Caulifigura coniformis|TrEMBL
MAGVVFAASLFGILTRPVGFLAAFWPANAVLLGLMVRYPQLATPSGWLAATAGYLAADLV
TGGGLLMTIWLTAGNLAGAMTGVFLFSRLNAEHRHLRRPLSMLYLFAICAATGVAAAAVG
GGAGPVLIGKPWWTSCAFWFATELVNGILLLPVILTVPRPGDIRSWKGQLFNQFRTDGAA
ALPVLTLLASMVCSLLLGGPGAIMFSVPALLWCALSYDIFTTACLTLLYCSWMLVAVSMG
ALVIHPNADYIDQTMSIRLGISLLALGPLTAAGINSVKEELLRSLNHAVSYDFLTKALAR
RAFMEKGGALVRQRSSRPRRLAVLMMDIDHFKRVNDHYGHAAGDQVLVSFVSMVASVLRE
DDLFGRLGGEEFAVVLPNIDPVDAAAIAERLRAKVETTPVALKEGEELRITVSVGLVYPP
ESSSLTLDRLLTEADAALYRSKQAGRNRVTTAQAHDSRFDRDLSS
>G7Z7Z7|diguanylate cyclase|EC 2.7.7.65|Azospirillum lipoferum (strain 4B)|TrEMBL
MSARVLVVDDVLPNVKLLAAKLTREYFNVLTAYNGPDALEMVRRESPDIVLLDVMMPGMD
GFEVCEKIRSDPATMHIPVVMVTALSDIADRVRGLEAGADDFLTKPVNDIALFARVRSLV
RLKMMMDEWRLRESTSGQFGVIERSGTMLSESFEHATVLVLEDSMLDLEKVTETLRRDHN
TVMSADTCAKALERALGSELDLVVVSLTLLNEDGLRLCSQLRSHERTRQVPILLMVDEGD
LAQVAKGLELGANDYVVKPVDRNELLARARTQIRRKRYQERLRSNYEQSLSMALTDSLTG
VFNRRYVNAHLPRLLERAIDSHKPVSVLMFDIDHFKVVNDTYGHTIGDEVLREVSTRASR
NLRTFDLVARLGGEEFVVILPDTDGEAALIVAERLRSRIADTPFAVSADRGEINVTVSIG
ISIGGRLGDTAEGLIRRADEALYEAKRSGRNCVIADARADRVEG
>A0A8F8G9R7|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MLAKSSRFRSISTLLIQRIVLLSLACLLLLGSLHAWVEFRLEQKNFERSMGRLADNSMRT
LSVGLWDIDRYTVRDQVAWMAALPEVAHVHVKVYATGEKFMAGRDMADVPATVSVPILPP
DGQEKPLGVLEIWANPQYFISLMVQSTMRVALGYALFTLLICVMVAWVMRRELRQPLSQI
ARFAAGLKPNQLATPLRLNRPQRGKPDEIDLVIQGFQQLQSDLRRYIDNLDQLVADRTQK
LEELVDEVKRLSLMDALTGCFNRRALDERLPSELERSQRYRRPLSVAFVDVDHFKRINDE
HGHGMGDMVLREVASRLQSSLRSQVDWVARYGGEEFLLVMPETAAHDALEIVGRVADLLR
STPVLVHGQVVEVTASFGIAQLRDGENMTNLLQRADSMVYQAKADGRNCARMAL
>A0A330DB97|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
GEVLIVHKKRFAYWSWNPKDNNDTLGALVSRWLFPVPIAQPIMHNGSMIGEIRLTARDSL
ISHFIWMSFAVLTGCILFATVVAIAITHSLHHGMVTALQNITDVVHDVRTNRNFSRRVKD
GRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAAFRNSIAALM
NDPSARINSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMVEFGDKRHQSYRLGGDEF
AMVLYGVHSELEVQHICAALSQQFIRPFDLHNGQKASMSLSIGFALAWENASVEALLEKA
DRNMYQVKNQRTKTIS
>A0A7I6TZ39|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-ESBL-04|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNALLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYLAKQNGRNQVCTED
>A0A330D750|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGAINLSYTAINVIEAVVGALLLRKLLPWYNPLQN
LSDWIRLAMGSALVPPLVGGILVIFLVPGPEPLRDFSVWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTMAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVVSLMIAHNPEALTTQHEGPMINAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EARFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGERGPLMENIHSGDMSRSDIDQDVVLNCRTGGAFDIHYSITPLSTLDGQSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSMMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
TGRLVHSINDYHFMWEGRLHRIGASAGITLIDEHNHLASEVMSQADIACYASKNSGRGIV
TVYEPQQERDHSTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSDFFRTSAARIASKGMGIALPLSAAGLASVTLV
DELLDLLDKSPMPGRLLHLVIPAGVVCDSDENLQRGLQKLRQAGCRVILSQIGRDMDIFT
HLSPNMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A6J4FWP0|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MIKFSDPIDVASHCARAALGMMDRHGVPAHPNNFVVWYAYVADRDPELTKAINGILRSGQ
KFNDMVSADLFERFFGTSQQEAELRAVGQRIEDAVGRVIEYLSTANQGAETYGAALESFS
GELARGPAVANLGTLVKTVLDETRVMVEVNRQLEERLENSSGEIARLREDLDQLKREATT
DALTGIANRKLFDVSLREAALEAQEDRKFLSLMMVDIDFFKQFNDTHGHMVGDQVLKLVA
RTIQDCVRGKDTAARYGGEEFAVVLPETGLKDAIQVADTIRRTVASRKIMNRRSGQLLGQ
VTLSIGVAEYDFGEPLGGFVHRADEALYLAKRQGRNRVLSQDDVNAAGSVGFQE
>A0A2C9D7X2|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MTLLHVPTMLFVLTALLLLYAGYFGLAWWMDRSRVYNAFLMAPMGVGAVAVALFALRGHI
SDLLSIVISNALVLLACGLLLTALRLFDGRRALALPLLAGALVWLVACSIPAFYGSLISR
VAAMSLMMSIYMLAMAREVMRNHRQEPLHSRKPLAFVMIVHAIVFAIRIPLMWNHPLADK
GGLLSTPWISAIVFELLLHWVAFALLLVSLSKERAEADLRKRAETDALTGLLDRRAFLEK
LQSVFGNASATSSFVLFDLDHFKSINDRSGHLAGDRVLVAFSRILESHTPEGAILGRIGG
EEFGCFFPGVDRDEAAEVADRVRLTLVETDILVGDKLLRPTVSSGVSDIEEAGASFEGLM
LLADRRLYAAKSAGRNRVIWMDDPAPARDLEALAIATVRPVAV
>A0A128FE32|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MSNFSSDDDVILLKEKLQHSQLVFRDLALKSRREATILKRLISRLIAASQVHDDKVLNER
LSQIRRELDTQEDVSRLIPQLALVERMVNRHNQATERAKDSLECQFQQSGETLKCLPGLP
AQLKRDLRNLLTSPAAEQKGSTEKIVALLQLYERALKLLSLPSNGLSARDLLNIDRINQL
CSELQHLITELDFDGEVGDRLLDIRSRLLLSPDAQTLLELTLESVQLILDGTRNERKASQ
AFLSQLNEDLSILQRHNGRSIDSSQAIATQRSSLNEELAASVDSIHTHLQDAESLEELRP
NLSQVAVNLASLVARNRELEEREQQLMEQLQHNEQKLEALYQQTMDYRRRLGDQERKLLL
DPLTKVYNRAALDDRLEHEYRCWIRYQTPFCLAMIDIDHFKSVNDQYGHLVGDKVLKVVA
RTIHQCLRDTDFIARFGGEEFVILLPDADEETRKALLNNVRETVSRLPFKFKDTRLTITV
SIGASLFKDNDNTVDVLERADNALYNAKHNGRNKLVWA
>A0A5B8R2F0|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MAKLVSLLVLLLGMLISFGSFANTMSIDEHTPTPLNLTPWLMVTHSNPNSQLDDIQALPK
TQWHKFTSGDIQRLSQHDFWLRVNLTSRDESLARILALDNPLLDKITLYHVVDNQLNNTT
FMGDTFPYKQRPLLSNIFLYPFKINANEQHTFYLHIETEGNAAIPLNLWSANDLAQIAES
TAVEHGFQLGVLAAIGIFSLFIALASGSFSYSYYSGYVLCMTLLVATINGYAFRFLWPNW
PALQQLMVPVLLPLVMAFALMFTEKILQLKYYNRRMLLICRYSAVYILLVGLFVPFIRYG
TALYIEIISVAILSIILMVLAVVQAFNGQKLAKLYTIGWVSMLTGACISSLLYLSVIEFN
IKPQTPVMLGLTFEIIFMSLVLAIRYNDERKSKLRIQQEALKQAQKIRSAREEALKVEAE
TNERLEQMVQERTLELEITLRELHEVNQKLTEQSTIDSLTGVKNRSAFDKRLLAESRISR
RQETPIALLMLDIDRFKSINDQFGHLAGDQALKVIATTLQQHLKRPTDLVSRFGGEEFAI
ILPNTTADGAIQVAESIRDAVTSIGLEWEGKPIPLTVSIGVSADVISNDQHSTELLEQAD
KALYQAKNSGRNQVKLYAPAQTEPT
>A0A554X1N0|diguanylate cyclase|EC 2.7.7.65|Tepidimonas taiwanensis|TrEMBL
MRQVLQHLEHLARLTRGKDRDSLDVTLVEVLRSLLDARSVALREVLVEDGVDRLLTRGQL
EEGMTAPAAPPPPDALSALPRLDADPEAAEALRARHTRVHAGPNGYRILVPVLTESGRRL
LIDAVRDHEPEEYQLRVVEGMARIFENVVNLLDASERDTLTGLLNRKSFDDTFYKVTRGA
ALASEGRGQRRADDGTYWLAVVDVDHFKQVNDRYGHLIGDEVLLLMARLLRGSFRHDDRV
YRFGGEEFVALVRAGDPAAAAAAFERLRRTVEAHPFPQVGRVTVSIGFTRLRPHDTPADA
FERADRAVYLAKAQGRNTVRCFDTDIGADAAPAPRESQGDVELF
>A0A2K8L9X1|diguanylate cyclase|EC 2.7.7.65|Mariprofundus ferrinatatus|TrEMBL
MDATPSTPVAAKVPYKVLLVDDQAIIFEALRRMLAEARDIELHYCGEGARALQMAGEIEP
DVILQDLVMPDVDGLMLVKFFRANPNTADIPIVVLSSKEEAKTKADAFHNGANDYLVKLP
DQIEMVARLRYHAATHKTLLERNAALEKLKRISRTDGLTNIFNRRHFDERLENEFLRARR
KKLSLAVVLLDVDHFKQFNDNYGHQAGDDCLVKVAEALRSSIRRPADVVARYGGEEFVVI
LPETDREGVLHVAERIRKAVMEMNIPHEHSSVSDVVTVSLGIAYAVPSEDAEEGQAESLV
KLADQGLYKAKESGRNRVAEAA
>A0A1V6BXF3|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin133|TrEMBL
MEIQWPDLINLTYDMIFIIDKSGSIKFVNKAAEENLFYTKEEFLNMNLNEILFESEKFIE
ILDTIIASADEKDEGRFQDKQIDISIIKKEIGYQDLILISKDTNLKIIMANFQVRRLFIE
GEDYFLLILRDVTERRFLEQELFKITENLELIVQEKTLELQKKNEILELLATTDTLTNLM
NIRKFRETLKLEIERCSRQKENSVDTFALVMVDADHFKYYNDTFGHQVGDEVIKNIGRIL
LESTRKIDTVARYGGDEFILLLPEADYVGVIKTCFRIRELIKNNLKMKKIIRDVLNVDSV
EIPKEHKISLSIGASKYERHKTMDEIINEADNALYHSKEAGRDCVHIHYKGEYRLVSEDN
FDITHYK
>A0A679IZ61|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MKVKPGIVPPTDHPPVVGDAFSLYDTEEAVLGKTDGMLAGLAQVAGGVQQLAEAYRRSYR
EQRRLVRMSDRMQLDLQKANHRLAEQQRDLQALNEALSGEIEHRTRLEAKLRHLADTDDL
TGAVSRRRFMELSQREWLRYERDRVPACLLMADLDRFKRLNDEFGHAAGDAALAGFVETC
RGRLRKVDVIGRMGGEEFAILLTEIGADAGLTVAEDICRLVGETSVAWPGGPLALSVSIG
IAAIEGAETFEQTLGRADAALYAAKHAGRGCVRPARGPSADVTPP
>A0A376E0K9|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MRFPGIPENEEERLKSLYMMDLLDTRDDERFERLTRVTKKLFQVPVALISLLDRDRQWLL
ACQGLNTRETTRDVSFCGHAILQEGPFIVNDARQDERFHDNPLVTGEPFIRFYAGYPVRL
PDGAVVGTLCIIDGTPRDFSDDDIATLKDLAFIVEDEFHVISMAMTDSLTGIPNRRGFYR
RGEKRFSALQENTEPFSILYFDLDRFKPINDLWGHAEGDEVLKVFASQLRQHLGPKDIAG
RLGGDEFAVLLARESDTQPFLNNLRTSLDAHNLRAGKPYNINYSYGMLHRDSGNYDSLLE
MIKESDNVMYSEKRRKRIG
>A0A376E195|diguanylate cyclase|EC 2.7.7.65|Cronobacter universalis NCTC 9529|TrEMBL
MDLHQIDLSLNELNHAVKLHYEWTGKFLELVLLGREPDNSFIHPQSHLSCRFCQWMTRCD
NSPSRYARFIENISKAHQTMHDTAHTLIRLIADKQVGSDELYAYHDAQQQFVASIDDYRQ
QLISLRNRHDMLTGLPLRQLLYEDFDFLHNSAREQALWLLIIDIDRFKKVNDTYGHNAGD
DVLREVAQRLKSEARDGERVYRFGGEEFIALLAGHTQEEAREAGLRLCGCPARLPITLND
ESLQVTVTGGLTGIRRDETLHEAIGRADDAMYFGKNNGRNRCILTLDGLMRETLK
>A0A379ZQ02|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MSLELLQIAALNLKKAVPLMLKHKIPTTPVNYALWYTYVGEQNPELNRQLDTVISQYNTC
PPVSSELLYRQYVADPVELDVRGMRQSLDAMVTELSQSLKDTNLDANDFQSRIDSNFEKL
NRIEDEGYSVEQVLDLVRSLVKESDNIRSSTEFFTGQLQKAQTEIDALKKKLEQTEKDVL
YDALTGCFNRRAFDIDFSGMLAQAPLGTCVILVDIDHFKLFNDTYGHQLGDQVLRAVAKR
LQESCRDGVKLYRFGGEEFAIIVPKSQLRVARQLAEGMRRGLEKLSLKDRRKDERINNIS
ASFGVAQWQDKQTGMQLIEAADKLLYDAKRLGRNRVLPMSS
>A0A4R0G2U2|diguanylate cyclase|EC 2.7.7.65|Enterobacter wuhouensis|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGMMLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWESISLVYTVVNVIEACVGALLLRRLLPWYNPLQN
LNDWVRLAIGSALIPPLIGGVLIHFLVPGAEPLRNFLVWVLSESIGALAIVPLGLLFKPH
YLLRHRNPRLLLETLMTMAVTLVLSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSMMIARDPSSLATQHSSAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLDQLVNGDINTYSLEKRYYTRDGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYDIPAHIKPTWQLWHEAML
PEDREHAEQVLRDSLMARLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWLQAEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRTDIEQDVVLNCRTGGYFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHAINDYHFMWEGRLHRIGASAGITLIDENNVQASEIMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTYAAQVASKGMGVALPLSEAGLASVTLV
AELLELLEKGTLPGRLLHLVINVDVVRNPDENVQQGLQKLRHAGCRVVLSQVGRDMNVFN
HLSANVADYLMLDAEVVTNVHGNLMDEMLVTIIQGHAQRLGMQTIAGPSNQPMMMDTLSG
IGIDFIYGDTIGEPQPLELLLNTSYFAIN
>A0A7U9G9M2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli H299|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDNSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A829G5S6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE36|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A375E7J7|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MKARTDRSALTEPRHRHTQRLFDYLSRASRNLCAAAQPAHALQVLAMAVGFAFFLVLLSI
AGRELDRLHDDTLLAQQHALASRALRIDENVQGGMRELRFLRKSTEQTLKLHPTPALSAD
PPLHEAYRQRNNASWAVSEPAGVPILGVGPSVLEGLAGFERIDANLPSDLVAARLFSEVL
GNIVFEHPFSSRPVYVSTNGLLTAVPALPVSDAPALMQLVAARAYFRRAVNGQPQEDIFW
GTLQRGAGTNPPVYGFSVPIYAHGKLRGVIVAFVRHDYLQQLLAQTTQPSAQSVLLDRDG
NQLAVSGAFDWQAARADLRRIQARPRLGNAPGAGIVRTWDGTTLLYRWVNRDWLLVDALT
PRELYRGMLANVSGPFLLSALLVLAVLGWVAFRLHKALRQQVARQARLQQLCERDPLTGL
ANRRRFSDAFDEAQRLRRKHDGVLAALMLDIDHFKRINDNWGHGNGDAVLKALARVCQNQ
VRPGDVVARIGGEEFAILLPGATLDEAAITAERLRMALASCLVAPADQIAARRPISNAIR
FTASFGVAEALADQAETLEALLAIADRRLYRAKATGRNRVVAQDGENSVGLALAA
>A0A6N3R5K0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIVAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A1B7IPB8|diguanylate cyclase|EC 2.7.7.65|Buttiauxella brennerae ATCC 51605|TrEMBL
MFGNAFQCVISRFKSPQKIVNLCFIVVFLFSTVLTWREAVVLEGAYVANQRNSLDNVATL
LDRQLQHSIDNLLFYRNAMLYALESPISTDRTRKSLADFDTFRTQPFWQLRLDLNRSLPM
SGVSDEFVRNSPLLDRDDQTLHSELSSALELSYIMRLSDRSGTLQQRMFYASRSGFFLTN
TPPANDPNIVSLYYRLIARPYFYSQSPENNPKRALKWAHTFNAGATTGQIVTASVPLDFN
GRWYGVLALEYPINSLHNFLQQAKYDDHEGTVLLYDNELNPIASSLEHMPTHSLFTDPQL
ARIANVVTSAKQGAQGELRMDSRFITWAKLNNFDGLLVKVHTLEEGVQGEFGRISIVLTV
LWVLFTLMIFASWIVIRRLVNNMFSLQQTLSWRANYDTLTRLYNRGAFFEIACKLSRECE
QQGLPFSVIQMDLDLFKSINDRFGHSSGDKVLTHAATMLSDAFRTGDVAGRVGGEEFCIV
LPDTTLEEATKVAERIRVRINSKELLLKQGNTVRISASFGVSSADEFSDYDFERLQTYAD
HRLYKAKQNGRNQVCHHD
>A0A6N3QYF4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A399F5B5|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MEWVGGLLLGALIASAGWRVAYLRVLEQSCTDSLTGLPNRRGLERALARELTLAERSGEP
LCLVLFDLDAFKRVNDTFGHAAGDKALRLVARVAREKLRRSDWVGRWGGEEFVAVLPGTL
LLAAETIAQRLRKAVSALEPVPACRLSISLGVAAYRPGESAAELLERADALHYRAKRAGG
DRACAEGSGLELDHVARVIG
>A0A3S4FEV3|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MFEPCFPENEAERLSVLNSLNVLDSNSVEKLDRITRLAAKYFGVSIALISLIDRDRQWFL
SRFGLDARETPRNISFCGHTILQRETLVVPDTATDPRFFDNPLVTGGPKIGFYAGQPLLS
LDGLPLGTLCIIDSRPQPFSHDRARDLRDFAAVIEEHLHSVERDIYTESLKSDLQRSDAM
FEQTFSQAAVGMALVSLEGYWLRVNPRICEMLQYSERELLERTFQDITHPDDLHIDLGLL
KQLLANEIETYSMEKRYYRADGSTIWVQLTVALNRLLNGNPHHFISVIVDISERKAAEAD
LFALQHELEERVELRTRELSVVVNKLNLEIDSRVLTEHQLSAEKERLRAITDNMPALISQ
IDNEERYLFANSAYKTWFGLDEARLKEMTVRELIGETAYAKAKPMIEKALCGETVSFENE
LQTRQGLLMIHTTLVPCETQGFYILSMDITELKCLQQRLEYDVTHDMLTGLTNRRAFLRR
LAGTLQLCCPQQQMALLFIDLDGFKAINDTFGHDFGDLILKTFAKLLSACAGTNNSASRL
AGDEFTVILWPLINPERQVSEFCEKVLTQLAAITQIGNQKVTLSASIGAAISSDGNLSAE
ALLSKADGAMYQAKSAGKRTYTIR
>W7NIW6|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MALHSKKLSFTRPIMLSFAGILCSFAVIAIAVTLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRSAMYFARDDRLNETLNVNPTQGLQMMMHLQNLMPTVSSISLADTQGH
YLRAPEVLPTETSKTFDPRTRPWFVAQAEASIFSHYTRPYMDYFTGHPTVTLYKPVISPE
GRLKGTLAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSDATLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRSVLMHIINAIKTGDVSEAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDSDIAELLNAQRPFAMALVDIDNFKAINDTLGHLTGDIVLRNVAREGIQI
MQPHHVSLYRYGGEEFAVIFQVEQMTSALSLLEAWRTAVEKRVWREENLRVTFSGGLGEW
HFEPLEHFIGSVDNALYSAKQQGKNRINRTSIS
>W7P6D9|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MKENRREIVNDSMQALHALAKLMPQLHAQCSLTDMLTTISRALGASLAWVSVNGDDGLQR
VVCAGEMTCHPFEVADFLADTLLQRHHRSWRVVYWKENIGRALFPPQHPGYAQLHSGVLC
KLSTHNWHCSGYFFLAFDERLSSLPILKNIVVVLVEKLKDYFAEIIAREKTAQEMQRVVT
QYKTLFERAPVLMNSFDKFNRCVLWNAECEKVFGWTMAEIAEHADPLSLFYPDPEERRRV
RESVNVSPLKDMYEWHPLRKDGTPLTVLWSNILLPDNSILNIGLDITERKKAEQQLQVKA
TTDDLTGCFNRSAILQQLELALAASARQEVNSHFCVLMFDLDFFKQINDEWGHPVGDAAL
LHFCNAIRELSPSDSALGRVGGEEFLLLLAQTNGNGAAQLSARLRTFLQTNPLAVGERKV
SLSFSAGVVEVSGGQRDTSVLLRRADKALYEAKHSGRGKTVVAADYL
>A0A1R3VJ06|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium prunaredense|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTATNGLDAIETCENGKVDVVLLDVMMPDMD
GFEVCRRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKTLTDELRLRASTTRNIGIEELLSRNFASADTTPKVLLIDERKSSFERVQKMLRGSAD
LDIATDPHAGFFQAADTPYECVMISTGFADFDPLRLCSQLRSLDRTRFVPIILLAEQGEE
GRIVRGLELGINDYLMRPIDQQELTARLRTQVRRKRYNDQLRASVTQTIEMAVTDALTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKTVNDAHGHDGGDEVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGAVAEKVAERIRAEIAQMPFAVGQDGKTVEVTVSVGV
SSVLKGVDSVAGLMKRADLALYEAKSAGRNRVVAKAA
>A0A3A3Z7R5|diguanylate cyclase|EC 2.7.7.65|Enterobacter chuandaensis|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGEISLAFTSINVIEAFIGAVLLRKLLPWYNPLQN
LNDWIRLAIGSALVPPLVGGVLVYLLVPAPEPLRNFIVWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLVTMAVTLALSWASITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPAALTTQHVGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQTELQLLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDAML
PEDRAHAEKVLRDSLVSRLPFKLEFRIRVKEGVRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEQGPLMENIHSGDMSRSDIDQDVVLNCRTGGSFDIHYSITPLSTLEGKSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSMMLTLLRSSDVLARLGGDEFGLLLPDCNIESARYI
TGRLIHTINDYHFMWEGRLHRIGSSAGITLIDENNYQASDVMSQADIACYASKNSGRGIV
TVYEPQQERDRSTRSMLSLDEQWHMIKDNHLLMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRAGLAEPELLHALDRRIFSEFFRNYAAQVASKGMGVALPLSAAGLASVTLV
DELLDLLDNSSLPGRLLHLVITADVVCHPDENLQRGLQKLRQAGCRVIFSQTGRDMNVFT
HLSPNMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A3E2YHF0|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MW-13|TrEMBL
MRVAHHRVVRDVTVRLPMASTAVEACQWTVAALARYAPATISVLLHVPDRLRCVAATGAW
QVFSTVPPKAGIVGRVYASGTGATVPDVTADPDYLPVRPDVTAEVCVPVLDPAGRPIGVL
DLQWSGPVELALWRETAERVAGRLGARITALGGPPAESRSEKLLRHAAALTVAPTEWDLM
TTAICAAREVSTLSAAVLLLADGAGPRLGAPTGTPGELESRVRAELTEAGAPALHRMIAR
AHRHGPGYTLGEAGHPPTAEYRPLADAGVRTLVAVPVGPPDRGGVLLVADERLLRPDPTT
VNLVELLAGQAWTCLDRLRTLARLREQASSDPLTGLGHTGPFGQRIARATPGRTALLAID
VDGFKAVNDTYGHQAGDRLLVGLARALEAALRQGDELYRIGGDEFVAVIEVSRPEEAVRI
AERLAEAARSTGRTISVGVALPQAGEPSEQTLRRADQALYAVKRQGRDGVRLATT
>A0A173SDR2|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MTIHRLFSKDPNDEEENVTQNIYVFRFILFCIIVYSFEMLLNSVDIFIVDKTIFTRGYVT
GCLFAAVYVLILLHLGLEHPLTKYVSITAVSLIIMAASVSLTYHMIIIIMMPIIIAGMYT
SKQLSIYTFVFTVLSIIISTYAGYYYGVCDANMVLLTTTSMNHLVENGTFLLNQVNENPG
VTLALYYVLPRCLMAMSFVYVSNIVNQVIRKSLKNAMKMEEKAATDEMTGLYNKNKLLAT
IEKRTYDYQQVAIVYWDINRLKYVNDTYGHFAGDQMIVKVAQSIRIALGDAGMAFRYGGD
EMLALIPGGTGETAEKMIKTWKQTLAAVQVDCEIPISAAVGYAIGEHEKLKNVIAEADRN
MYACKHAGRNSTEK
>A0A5C6BIN5|diguanylate cyclase|EC 2.7.7.65|Symmachiella macrocystis|TrEMBL
MFLLRTMPSTIETLNRLKSWPLWLAVLAALALAAVVGWVDYIVGDAFDLSLLYVPIIAIV
CWVVNLRAAVMFAVLCSLIWLMDDWMASGIALHEVNVYWESAVRFLLFVAFAVVLTHLQT
ALQRESALARSDPLTGLANMTSFVEEAERVSHHSRRGQTPITVIFLDCDHFKEVNDRFGH
PQGDALLKDVADCIRSSIRHQDVAARMGGDEFAILCPSMDESLARQIAERVKGDLDVKMQ
SGNWSVTFSIGVATFPIAPPSVADLIRESDNLMYAVKHATRDGVRFKTVSNVPDVA
>A0A8G0SZY4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MSKVRANVFGLLYQALPAWALALLAVISGALFTAALTTAAYSFSKQQLRQRFELLAADRY
SRIAERLADQQQRLDSLRRFFSYSDNVTAGEFQGYVKPLLQRTLAYAWAPAVATARWGAS
AELAVHNASPDAGGQAQVQPLALRGHAYPIRFVQTSNLAGLPSGLELFNLRRVQSTLVRA
TTPGSMAVSAPWQLPEQPAAVVLMMLAPVFANVAGDGVPSGYVIVLLDLQRLVSEGVSAA
TDDDLVVRISDGSGQNLLYQSLNPAAPLAMASARQLQLAGYPYQMLIRPSQSFVHANRSS
LVPAVALLGALLSVLLGALLYSVLSQRQRALKLVEQRTAELRISEQSLRGTHNQLRSVLD
AATQVAIIATDLEGRIITFNAGAERMLGYAASEVVGRLDLPALIQADELHQRAQALSQQH
GRDISCAQAIFADAAQAADNQPGEWTLQRSDGSQLLATMLVSPVLDEHGRWVGYLAICID
VTERRRVHEALAVRDRLLEKLSAEVPGGIYQYRLDASGHTCFPYASQGLFDIYEIDLHQL
REDAAPITERIHPDDLERVLRSIRYSAEHLAPWREEYRVILPQAGLRWVRGEATPELGEA
GCTLWHGYLTDVSEPKRVEHELRALSITDVLTGIHNRRYFQERLKIELDRAARDGLELAV
IMLDVDHFKRINDEHGHAVGDDVLRSLCQHISHRLRRTDVFCRLGGEEFMVLCPGSDIAQ
ARTLALELWQGVRSLVINGVGKVTASFGVAAWHPGEGADALLLRADAGVYAAKQGGRDRV
EVVQP
>A0A8G0SRT9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S07E 245|TrEMBL
MIQSPQPSHERAKRSSDHVDEVPLPPLRKPVYILLQDHDRAERLAQQLEFFGLGVHALAT
AEAFCAAMRERLPAAIVMDVDFSGPGCGLLLAAQAQLGLDQAVPLLFFSLHETDTPTRLA
AVRAGGQAFMTGTLEASSLLEKVEMLTNATQYDPFRVLIIDDSRTQALHTERVLNSAGMI
TRSLTEPIRAMAELADFQPDLIILDLYMPDCTGPELAKVIRHNDRYVSVPIIYLSAEDDL
NKQLDAMSEGGDDFLTKPVRSRQLLTTVRNRAVRARHLKARMVRDSLTGLYNHTHILQLL
EDCSFRARREQQPLSFAMLDIDHFKKINDRHGHPMGDRVIKSLALFLKQRLRKTDYIGRY
GGEEFAIVLPNTPLSAAYKVLDEIRRRFAEIIYPAQPHDLHCTFSAGVVQLDQAHDALSM
ASAADEALYRAKHAGRNCVVRVDPA
>A0A261VMJ1|diguanylate cyclase|EC 2.7.7.65|Bordetella genomosp. 12|TrEMBL
MKLSTDTFVARWKETCAPYSRDILNLAFERVDKQAAELADTFYETMLADDAAAYFLSDQI
VHQKLHASMQAWLRSVFGAAVHQDYVTAVAFQQRVGDVHARIDIPVYLVLQGTRMLICRM
RATLARDPDIPAALRWPLSDYLGEIMLFAIELMSLAYANSHDRNARAEEGYRLLSLSQNV
GTEKERQRAALLDWENQLLFGLSVGDSADKLRRLRKSEFGLWFTHKAAHAFEGAKEAAQA
RVQIEAIDKLLDAPAEPQDRIRLLHAVREATKTLAYLIDALFEKAAHLDSGRDTLTHLLN
RKFLHVVMSKEVAYARKTDSALSVLMVDIDYFKSVNDEHGHDAGDVVLQQVATLVSTYSR
GGDYTFRLGGEEFLVVLVDADAVQALNVAESLRQRLADKALLLPDGTQRRVTMSVGVATH
DGHPDYQRLLKRADDALYAAKARGRNTCVLAD
>A0A3A8GAY3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter cumulans|TrEMBL
MPQNVSIQLSETWKSICDQYSALDHHLTVELITKNLDAFVAAFYKQMLLEPESAEYFSDN
IIQKRLIDTLKAWLLETFNVALNGQYESAVLRQQKVGNVHARVGIPSWLIMRGVREIERT
MFEYIASDNSTNYMNVVSYVVQLLGFSTEIMCRTYEDKTAKNHEVKHSYRLFSAMQDVAV
HKDRQRGSLLDWENDLMFKIFSGQGKFYQQLFSKSEFGLWFIHKASYAFTGSEQVGLITK
RIYEIDALTEECMLLEGREQLMLMVQKIRSINREIQHLVDQLFQVTEYIESGNDALTQLL
NRRYLNTIVGREISYARKHRSALSLLALDADYFKTVNDRYGHAAGDMALKFIAETLQKFS
KGSDYAFRIGGEEFLLLLVDSDLSRAKMVAENIRMCIEDTTLQTSVGEDFNFTVSIGCTQ
YDGHPDYQRFLDATDLALYSAKNRGRNCVYVTEVQKMA
>A0A7L6IEL7|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00570|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A3S4GKV3|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MTEANLTELRAGLLACRQMSRTGRSTEGLIEAQRLLVVARKLGDPGLTAACLTNIGWFCL
QLGYADEGLASASEAKALYFETDNHDGQAFATAVYSWLLVELGLSDLGFTEADAAVQMAR
HTALPALLSFVLGCKGMALMMCRQDQLAYPLLEEALALAEKGNDPSTTAMTLVNMGFSVV
SQAEFAEAAGHVEDGLRLRRKAMMFNDRAIDTARACGDLWNLRIALCNGAELAQGLGYRE
MARAFLDEWDSLPGTVGPRSRIHYLYTRGELLTAWGQLDEALAVCKEAVRLAANGANLDH
RVNTLRRLSDVEAALGNHQGALEHYRAFHEAFVYQMGESTRRRAQVTEMQLENERLRLRA
DRLEEEASKDALTGIFNRRAFESHFERIQGEVFSFAILDIDHFKSVNDRFSHMTGDAVLQ
RLAGVLGAWGEPVSAYRLGGEEFALIVAGRGQVEAMPIMEAIRVALEQTLWSDLAPGLAI
TVSIGLVDSVQFAGRSVISEADRRLYAAKTQGRNRVVGGFDTEPVSLRA
>A0A239RVS6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MFDADRASITLQDTEEYLKLYSISGNHAIPMDFKIPIGQTFVGRVFACAKLIICDDLSQS
DELDCRMLSEHGMGTCMDAPMIHNGVCIGTLNVADQRKHHYTLQQAILLQSLATWLALNI
KLHLQVQEMAVLASTDELTGTFNRREFVQESNQTMQHFSHARVPFTIGILDIDHFKQLND
CYGHTAGDHVLKKMTKKIKGILREGDFLARIGGEEFPIILPACLGDEAMRVFKRICSTIE
AMEVHYEQEVLCFTVSIGVAEVGKHDTDAEDVFKRADKALYCAKQAGRNRIHFAN
>A0A6H2GEK3|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. SCLE84|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0Q0P928|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MAELNNSKLPVHVAELKFALDNVPAYVYIKNELGHYVYANKLTLGLFACSEQELQHRSDV
DFFPIPDVKKLAKIDKRVLSGERTREEVELTFPDGHQYIFWEVKTPIICDTEPNKVIGIL
GIATDITERKHLEEQLLYAASTDPLTELLNRRYFYIRLSLALQMSKRDQNYGAVIFIDLN
KFKKLNDQYGHNTGDAYLVEIAQRMKTVVREKDCLARIGGDEFVVLLEGLSRNEQTAKQN
AYRVADKLQTAIEVEFIHQDLNYKGSASVGVTMFLGTQKTAEEIVAQADQHMYLIKHALN
Y
>F7SN23|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. TD01|TrEMBL
MRYKDKHQLAAEWQVLLERTPILLRQAVETLVEHHCDRFADHFYGVMLEDPHASLFLSND
QVRERLNPSMRRWLKAMFTVEQADFYALVEQQEKVGHVHARVDIPVNLVLNGARQLKQAF
YQQINAMFATPLSPGDACVYVSDHIDMAMEIMSHAYSVANDRNARTEEAYKLFALTQNIG
DERERQRSALLNWENELMFAVAAQQETATLPKLSKSEFGLWYFHKACHAFEGAPEITTIS
RHIRQVDQEWLVALGQDDMGQRLNALSDIRDAARTILMLLDDVLERASGLEAGRDSLTRL
LNRKFLSVVLSREIEIGRHSEKRFALLMVDIDHFKAINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDSDPDGSRLFAERLRQAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQLADQALYQAKRSGRDRVVVQNA
>A0A1C3ISD7|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MTLYKQLVVGMVAVFILLMTSVFMIEFNTTRDYLEEQQRSEVNNTINTVGLALAPYLEEK
DQVAVESVINALFDGSSYSVVRLIFLDTGDDILRSYPVKPSGVPQWFTNLNLFKPIHDRR
VITSGWMQLAEVEIVSHPGPAYTQLWEAFTRLVTFFGAIFLLGLISISWILKRALRPLSL
IIKKMDQIAKNQFGEPLVRPKTKDLILVVDGINHMSTQVELAFKSQAQEAQRLRERAYID
PVSQLGNRAYYMSQLTQWLEESSLGGLAVLKAEFISEEYDDKGYQEGDALVHQLAEQLQA
SISSPDITIARISSDEFGFIMPNIDESELKLVASSIVNCIQNLGSDPTGMANPHIALGVT
YSKKRKTSTEIMSLVDNALSSAKANRELAYGYVTADDHGAVMGKQQWRMLVEEAIINDLV
TFRFQAANNSFGKTYHQEVFSAIEKEGVRYGANQYLYALEQLEMSHILDQYVIEKMIEKL
NAKELTSPVAINISPSSISQPSFIRWIGKSLEKNASIAHLLHFEIPENCFVNVPHYTALL
CNTIRNADAVFGVDNYGRNFQSLDYINEYRPSYVKLDYLFTHNLDDEKQKFTLTSISRTA
HNLGVTTIASRIETQTQLDILSDNYVEVFQGFIVDK
>A0A8H9P383|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQNVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>D5CRG5|diguanylate cyclase|EC 2.7.7.65|Sideroxydans lithotrophicus (strain ES-1)|TrEMBL
MIKHSKVEDFAADWQQLHQQVPESTKKLICDTVDRYAGDLATQFYDYMLADKEANPFISH
DIVSQRLHASMQGWLRELFSVQQHDPKEIYKYQCHVGVVHARIQMPISLVLRGSRLLKQA
ITEHLVETELDRAKLVQATRFVSEVMELSMSAMTDSYVINVGKSVRTDESYRMFALGQNM
LAERERQRAALSEWAQHILLHLLGDEGTGVPEMKHSEFGLWLQHKASIIFHDAPELERIR
VCVEKLERTLLPGLIEKRRNGGNAREAMRQVEADIGEVKFLLTGLFDRFIEVESGRDSLT
RLLNRRYLPTILMRELALARNSDVPFAILLLDIDHFKNINDTHGHDSGDMVLQQASDLVT
SSVRVGDFIFRYGGEELLVVLVEIGRDQALQVAETIRERFAAEPMRVGDGKVMQVTVSIG
VAAYNGHPDYERIVKDADDALYRAKNSGRNRCELAD
>A0A1Y6KDU2|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. ORS 285|TrEMBL
MGYHFEKLAIEYDAMSAAKKKTSATISNDLFEDIPVLKRKWHAALKPGQSLPRYEDVMLG
SLGRLADHVALLREEDDRLEITRSGRYVQQWLQNDGWDIPVECVSPDCATVLTEAAICAA
SSCKPHLSTAHCVRDGMVRTYDVLALPTCSRWGRTLVGVYINERATQYNLLDSIFSTTED
GVVSLATIRDSTGHPCDFQVVHHNQSAANLLKLSAAELQWRRLRQGGTMLGTAEVLARLF
AVVTQSGRDQLELDCDDRSLRLGVHAFGDIVSLTVSDVTALKRREASFRLLFDANPLPMG
IFDTETGRILKINAAAEEHYGYDRSSLLEMTIWDLWPESNTSNLDEAMARLTARDDFHRE
WQHYKADRSLIDVLAYGRRIRYDGRDGFLVAIVDITERRKVEARIAHMAHHDGLTNLPNR
EFYQERLRQALEPGPAGNKPVAVLCIDLDLFKNVNDSFGHPMGDRLLQAVADRLRERVSG
GNLAARLGGDEFAVILGDAPSVNEASDVAARLIQALSAPYEIDGQELVIGASIGIALSPS
DGETSEELMKNADMALYRAKEEGGGVHRFFEKEMDLQAQKRRDMEHDLRHAFAQGEFELH
YQPLVDVASNAISGFECLLRWRHPEKGMISPADFIPVAEDIGLIVPLGEWVLREACREAA
RWPDGITVAVNLSAVQFRSRNLVQVVMQALAQSGLAPDRLELEITESILLAETEANLAIL
HQLRGLGIRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRSDCLAIVRAISGLG
KSLNITTTAEGVETSDQLDWLRAEGCNQVQGYLFSAARPASEIAGLLAQFGARASKAA
>A0A7H9FQ01|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRFRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGMWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A239SJC6|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MPLVNAPLSRRHAASAFLCGVVVLLCVLVAWGLARFAADQLVANRAARLLYEERSIATRL
AHGTVHTVNQDLMLIRGIPQVLAQIEQIQSAANTIATHPLTEVAQDKARQMLLANPVLKP
VNELLRAAQLYFGADLVWLGTPDGITIASSDFNSTNPLIADRYGDRDYFNTAVLGGAGQQ
YVTGRKTGMPGMYFTAPVYQEGILVGVVVVKLGIRRLSHWVDSGASFITDKNGVIVLAND
PTFTGLAVPGAAVFNLSRPERRHLYMQEDFTVVPIENYDLTPGTPNFLQVGPDDEDNKHS
ARLVRVRPDNQPYLLDVEPSSDGDMVIYTMSEAPTLGSLLIERRRYALLVFALLLSSAGA
LYLLVRYLRREKLQLTDTLAKNAALEHEVKYDALTGALSRGHFLKRLRAEVMQADSANVP
TSVILVDLDHFKQINDTWGHALGDTVLASFVRLCHESLREDDICGRLGGEEFAIILSGAT
EARAFDAAERLREAVRESSINVDGRTLQFTISAGVAQWHTGDDDNAWLQRADAALYLAKS
RGRDGCARESDLRVLTRGGS
>S1F9L5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE73|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7W6EA18|diguanylate cyclase|EC 2.7.7.65|Aureimonas pseudogalii|TrEMBL
MATLLSLSVMLVDGIGQMAIIAVVFGVLQRRRAAPILRAGWLSLLFAAAGLLAMARPVEV
VPGAFVDMRGVVVGLAGAFGGWPAALVSAAATAAYRVVLGGHYVGGVLSILLAMTAGLVW
RYGLMRNRRVAGNRHLLLLGLMIACQSLLAVVVAPAVSPTMLLIMLTLAIASVLGSLAFG
RMIQRELRLIAEERMLADEALQDPLTGLANRRGFERAFLDARALDLDAPLALLLIDVDFF
KRVNDTHGHGVGDEVLVAVAARVRASLRAFDQASRHGGEEFAVLLPRSGSGCAWERAETL
RRSIAERPIEVASGEPIAVTVSIGVGVCGDGESSLKGLFERADARLYAAKSNGRNRTEIQ
SAAEPASAASAVAPVSAPPPVPLRSLAASAR
>A0A2A3MK03|diguanylate cyclase|EC 2.7.7.65|Pseudomonas abyssi|TrEMBL
MPRLSVEQLSQEWGLLNQRFSGHTRQFVLNFCTRHALDLTETFYSEMLVDPAAALFLSHE
QVQGRLSQSMRRWLEGLFYAEAEGGLARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIELLHEDRELSDREHLDAARLMSDTVDLAMEIMSHAYSASHDRNSRNEEAYRLFSVTQN
IATEKESQRAALFDWENQVMFDQAVGQPGAHLPRILASEFGLWFRHKGAHAFEGAREAGL
IIELMEHIDDVILPLFDGTTDERIARLRELRETVKSIRFNLDNLFEQNSALEAGRDVLTR
LLNRKFLPVVLNRQVGHARSHASVFSVLALDIDHFKRINDGFGHEAGDRVLQQLATVLVN
SSRAGDYLFRLGGEEFLMLLVDTDLSGARRAAEKLRRSVEREVFRLPQERTLNVTLSVGV
ACFNGHPDYQQLMRRADEALYEAKHSGRNRVVVVE
>A0A2T0ASK7|diguanylate cyclase|EC 2.7.7.65|Clostridium thermopalmarium DSM 5974|TrEMBL
MDVINKRYLILKNIDINNVVSSYVARDVTNNNVVQLNLLNSDYTPEKFIRFLIENFIDYN
NIDSSNIIKTIDFGLVQNINERKIGYKQYYYTTEYIKGIENIKDVLKGCSSDCIIDLFVD
ICSGVHYLHLRSILYESINLNNIYILNNGNKYETKLCDLISVQIDKEFFSGDNRENLIFM
APEVINGAMPSKTSDIYSLGVLLYILLMLRIGIEIDFFYDIHKHMKNTDIKLDLNIINII
NKMICEEENRYRDVREIIKDLNKALGKNYSVNKKADIEKLNFNNKLVDREYELNKVLSVY
NQIKINRTQSNMILIHGERGIGKTKLLKEIERFIYLDGGRVYSIYNLKSNNLSSKGLYEI
IKKLLESCSQEILKNYECELVKILPYIGNDKQVVTLQSLMEKKEKIRLLKVSENFLREVC
ENDEIVFIVDDIHLLDKFSIELIEYLYNNNKNIMFILSYCDDDALFDKELSEFILKERDN
PNSISITLKELSEEGTIRFIKDILHLDKNPVSFSKKIYEHTYGNPLFIKETLKNFLLNKV
IYIDENTGIWCSDYDKNYENLPIPRSLEQACMNQISKLNKKSYLIIEFISFFNNGVSKDI
IKDFLNGWDLQCDFIIKDLCTKGIICEKIEDRGFVYDIYSKILKDIVYKKVNDDKKSKIH
SWIADIFERENEEDKCYEDEIIYHLEKSGQNHKAIRYCVDSSEKMLKLRNREGALLSLKK
ALSLLNSEEYILKIELLIKVSKLYEDNANYKLAIDYGKNAESICIKIGEKRLLVDVYNVL
GSAYLKFGKPDKAIKYIRASENLLMNMDYEKAYIKNRFILARIYLKNDENEKAISICNSA
IELCGENHIKYKAILFSILGEAYMELNRAKDAIKSYKESYKCSESINYRKGIVVALNNLG
VIYGDYYQRESKMEEYLLKAKEICENDKFIYYEVISLVNLGRVYLAKYDYKKSLKYFLEG
LDKSREINFEKMFFYSLNQLSMVYFRNNNYEMAYRYYTLSQQEFKSYRKQVIDEVNFYRL
QGEFLFNIGFIEKAKDYIKKAVDILNMKECTLKWISEIHLQYINLIEDEIPQNMYKYIDK
IEELLCNFKKYKVFDIVYDTAIILYKKGKKDLAISLYNKYLYNFNDNSNPKIKLRHMHLK
GILSQDDNKIELLNSALKLSDKLDEQNIKYELCIEIGEWYLDRNQYIKGADYYFEACKII
RCLLSRLPENIKEQYIKINNLREPFYKLICIRNRYVEPEINYKEINSVEELLDFKYSIDL
LKDKTFIDEAKDIYSKSHSILAKNELDIINNLTSDSMANLEMILKYLVWTTLASKGKILL
EGENEKYVTLVSFCEECDDIENEEILKKVKNTKTPMLLNHQYTLKGDTAVICIPIIIKNI
KGAPVEGRKKNRKTYDFVKGYVYLSSDKILNNFNEESLGQCINLTNLIDYILEKYQLKIN
SCLDPLTGTFTRKCLEEKIEEFIEEADENKNIFSLIIFDLDNFKSINDSYGHQIGDEVLK
KVSSVVLENIRNRDICGRYGGEEFIILLPNVDKYEAKKISDRLRKKIKKRVILGDNVPVT
ISMGVSVYPEHGYLKYELIEKADHALYVSKELGKDRCEIWKREFSHIKHRNKLSGILSGN
LVQDSKNISSIIDLINIVNQETDLEKKIYDSLGEIINILSAEYASIVYMDEDKVKKSFKR
KINEEGWCMEQVCNNIIDEVVSKKQSICTMYWGEELGYDLINESSEWYSAMAVPLIRKGT
IQSIVCAAVPLKLKRFDYDDLNLFDTLCKIIRLMQ
>A0A8B6IUI8|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MPECQHPANRSLAAALPRGTLLPALLVIVAVAVGCALVSPPIGSPREILVNPGLYIDLLA
LLFLVFMLWSSARVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLFTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDTWGHLVGDEVLFALGKQLAKLTSEQIQPARIGGEEFAIIVDGLSEPELHAL
AQDILDNARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKRNGRGRVEWA
>E3PBE1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O78:H11 (strain H10407 / ETEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8F7U8H5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Z4RN97|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERNAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Y8G2N7|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U5NKG7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYQKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVM
>A0A146B3P6|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MDPLISRLAASLPAAKSLEQLTRPLLDMLGAVTGMESTYLTTIDLERDVQRVCYARNDGD
MVIPEGLEVTWSDTLCKRALDENCTYTQDVATRWADSDAARALGLQTYFSAPVRSEDGHL
LGTLCAASGRRLPLPQDAPAIMALFSSLVAGFIEREMLMRALQAANTQLLDAALRDPLTG
LPNRRALYEQLVRLLQHAPLDGNAVLVGMLDLDGFKQINDQYGHQAGDALLCAVGARIAA
ILRAGDMAGRLGGDEFLVLATGSQGNAAQAAAILQQRILEATCGDYTLPGVTLRYAGAST
GVIAILPDTGLDADAALRLADMRMYDVKRERRSQPRP
>A0A747PQZ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPTDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A378CSH2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MTFGVLELYYSCQFLFLPGVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTPH
>A0A6L5BN02|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MPRSSAVRFSHFLPSLLLLLAGLSAAYIKDLNVFFTSLFNVLPTLVLLLGGAYCAVYRRQ
RELFLMVTVYIAYFLLDTQTDYYRDNGKVREDAAVVFHLCCLLLPLLFGLFAAWQERTHL
FQDMVARFAVLLAFGSVALGVEQSYPQALLMWLSEIRWPALHGAWMSLIQLSYPVFIASF
VLLAWQYWRNPRPLHAAQLVGLLGLFWMLPKTFILPFTLNIMCSQVMLMIAAAVAHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMSDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKISGGGRAYRYGGEEFALVFAGKTLEECMPHLEVIRESIASYNIQLRNPDRPQDDQQGR
QRRAGSAASSVSVTVSIGVAERLEQRTPEQVLKSADEALYSAKGAGRNCVVAFGQSRRGA
VRMDGAAG
>A0A5T8B7Z3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A522X5Z3|diguanylate cyclase|EC 2.7.7.65|Gallionella sp|TrEMBL
MIKLEQSKEFVAAWRGLSEETPPQIKQLVRVIVQQQAPGLAGLFYQDMLANAEARQFLNH
DLVSQRLNASMQRWLLELFSDEPQNPEEIYKRQRHIGEAHARIQVPLVLVMRGARLLKYA
IHGHLVGSQLERAELVIATNFVAETMELAMSVMTDYFIIDREKYARTDESYRMFALGQNL
PAERERQRAALLEWAQQILLRLLADVGDKDLPGIKNSEFGMWLQHKGSIIFESAPELPQI
RQRIEEVEQSLLPKLVASRREHDDARALMNEIEEGIAEIKFLLNGLFDRFIEVESGRDAL
TRLLNRRYLPTVLMREVTMARRSNVPFSLLLIDLDFFKKINDNYGHAGGDAVLQQAADLI
AGSVRAGDFVFRYGGEEILVVLVEIDKDQALRVAENIREKFVAEPLRAGEQQTINITVSI
G
>A0A4R2N4H8|diguanylate cyclase|EC 2.7.7.65|Simplicispira metamorpha|TrEMBL
MSHHSDEQHAAEWRHLLHRYSAPVRQQVRALAAMHRHMLASHFYVQMMQDKVASTYLSHE
QVHSRLHASMQTWLTGVFALGPHDDLMPAVAQQNKIGEVHARIDVPVNLVLRGARSLKEK
MHALLQDDASLDGAQRAAAGQLVTQVIDLTMEIMSQAYSTSRDRNSRAKEAYRLFAVAQN
VSTERERRRAALLDWENQLMFDHAVGLQPGQLPRLGMSEFGLWFRHKGAHAFQGASETET
ILHAMQRIDEVLLPAFAQPGSEGQRIPQLRELREHSKHIAFHLDALFEQNSELEAGRDVL
TRLLNRKFLPVVLGKSVDHARSNGASFAVLAIDIDHFKQINDGHGHEAGDMVLQQMASLL
THHTRGGDYLFRLGGEEFLLLLVDTPLAGARRAAEKLCAQVAAEAFHLPRDQTAQVTVSI
GVAAFNGHPDYQTLLRRADAALYQVKHAGRNGVVVAAD
>A0A743VGM4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
VTLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A402XFZ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V8I6C9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTAFGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U4DWQ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTFAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0T9LAU7|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MFICLRTALHTQSEFNMNGHSYDQLLKSKHRLSLLLFLFLNASSSIFNMLLPAHHTPAFT
LPVVLIAILSISALLFIIFFSKDYANKLNIFAFVLGILWTWQIILKYEYLGRDENNFLLI
SLFTIFFISTIALSDNFIAFCLHSAPAAIAVILLDDFQNIFRIIFTVMLPLIGFCLHHLM
LRRSDEFTRKLVAHLYNEREKFSDLSMIDPLTNLYNRRGLESKLESLLTQSPGNHYVLLL
DIDHFKAYNDNYGHTMGDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQ
LAERVRQRVLGLDIPHVFNHKVSTTVTLSAGISPLQPLDLPASLKAADEALYQAKKDGRN
KVAFASDTLTNVESVH
>A0A1B7HNV1|diguanylate cyclase|EC 2.7.7.65|Buttiauxella noackiae ATCC 51607|TrEMBL
MAKTLRVIHLVFIFVFALTTFLFWQQGQLFSHGYRTSQLSHLESVIARIESKAQYKVDNL
RYLKRIFIEAMDDPLFPGVATVPSEITGDVGDSPLWIRELPLPDTLTEDSKFHGANALQV
RQQLYALRKIQGLFPLATGANELTADLYYISRDGEFIVSLSQEMNSLLESSYNPHEEQGS
FVLASPLLNPQREPFWTRQNIAKTDDTLVNAAIPVDFRGEWIGLLGIAFENDAVQKFLAE
SLPEDTQSAYQLFDEQLIPLTNAVGSVNKFQLTAQHLQTIREMLEVSSRGTMRDGSVFIT
FGRVVGTRSVLISTQTLSQGLHEDFGRFSILLIAMWGIFVLFLWGSHRVICRLVRNMGSL
QREMQRHALHDDLTGALNRRGFFAKTSQISPNYVDYTLVQLDLDHFKKVNDVYGHLVGDN
VLIHATQHIQRAIRSQDILGRIGGEEFCIYLPNSDLKAGIMVATRVKWELESSALVLDDG
RKLPVTASLGVASHSEYPEYTLDQIQSLADMRMYTAKERGRNQVCWQDDEAIGT
>A0A663BHC2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MTKHVNHVVRRLIIYFFICLLAGVGITGLTSSFETRFNSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVAFGFACSALLMLGTLSSYPDWLSCNPAPVVKQNDAVIYYFF
RNIMMAVLFTSSIILYYFRRRIMHSFKAHVMTFAACIVFTLMIIFLSWIYSSHSPWLSIR
FIDDLSHTFTPLWRSIIGWLLMAVWFIALILIIWFSKLRNIFWYSGAFFCSAYLFTIFQL
LSAVGELDQAWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVKAQHPLSVIICDLDHFKRINDNYGHIAGDKVIQFAASVLDSHSR
KDDAAARIGGEEFALLLVNAAEDEAQAIAERIRLAVSAEQTPLPERMTISMGVYTTHDGS
VTAEECVQRADEAMYEAKNSGRNRVVIWRRQGR
>A0A2S5D562|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MLLHIYVSFCITFTLVILTYWPFTHPTRRKSFIKDFKPILVGIIFGMTGLVLSAISLRFL
QGTLINIHIVPLLYSGLIGGPWSIIISGAIMGVGSLYIIPTQSLLSISSLSNINLIVLSI
ILALVACKKPITLHTLTTYFFSVMAEIIVMLVLAICLPPILKIGTILGFIAYALFTFFTI
FTVIKRLQATSEKVQLIYRLKEKDYLTQLPNNLAIRSFAQEMVLETDNFSVLHFDVDNMK
DINIKYGHLAGDGIIKQLATIIHHYIETKNGMAARVAGEEFYIILKDAPPAIALYHAEKL
RHVIAHHSFKINDRQTTPLTVSIGISSSPDNAVDFDELAIIATQVTTEVKALGGNQVVHA
NNSEFHKGC
>A0A378YD34|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MLNALFNRRRTVSALLSGTTILLGVLAAWAFSRFAADQLVASRSARLLFEERSIASRLAH
GTVHTVNQDLMLIRGIPRVLAQIGQIQDAAAAIDAQPVKRLPPKVARHALLANPQLKPVN
ALLSAAQQYFGADLVWLGTSDGVTIASSDADTANPLVGDNFGDRAYFNAAVLGGAGQQYV
IGRKTGLPGIYFTAPVYHDGRLVGVVVVKLGIRRLSHWVDTGASFVTDPNGVILLANDPT
FTGLAVPGARVFRMTPDERRHLYKREDFTVVPIEAYDLAPGTPAIFRHRGSGDTGKHVAR
LVRIRPDNQPFLLEAEVSTDDDLVIYTMSEAPTLGSLSIERRRYAVLVFALLLSSAGALY
LLVRYLRREKLQLSDTLAKNAALEHEVKYDALTGALSRGHFLKRLNSEVARAEATGMPAC
VILVDLDHFKQINDTWGHARGDTVLAHFVHLCHESLREDDICGRLGGEEFAIILSGATEA
RAFEAAERLRDAVHTSRIPVDDRTLQFTISAGVAQWHPRDDANAWLRRADAALYLAKSHG
RDRCARESDLRDLTRGGS
>A0A2H5ZFN8|diguanylate cyclase|EC 2.7.7.65|bacterium HR29|TrEMBL
MGTHRVDRRDLLDFVRDDGLELLLLSCPDAVVVAGEGDSVILFSGSAEWLFRSDPPAVLG
KSASDLFAPGEFDRIRRAVETEGAVRGMAVRGRRADGSEFPASVSAARLSDRYGGAAVAI
FVRDRTAQEELERELSERNERLRGLVVRLNEAAQRDPLTGLLHRGAGLARAEEAFLEARA
AERPFAVVLFDLDHFKGINDVYGHLVGDRALRRLANVIAEHTRRGDIVARFGGEEFILFL
PAANREVAAAVAERVRTAVARLRLEVEGLHLAVTVSAGVASVPECAPTLLEAIHVADTRL
LAAKRLGRNRVVAEDLEEGDQAA
>A0A1S7U6C9|diguanylate cyclase|EC 2.7.7.65|Agrobacterium salinitolerans str. Hayward 0363|TrEMBL
MFTVLECVAMQHDHAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVLAVFGFWFALITRSQAAHSPVIVGTLITLS
VAVMHFVGMAGMDVAATISYRGSAVVGGFAVAWVSFLLAFFLFRRLGSWQRIAAPAGSAI
FAICALHFTAMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSITAAAAFVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGREEASLIGQNPDDLFKAIDGQPAYLP
RHTPVEAVRERAGQAQIFELGVRTIEFRGHPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDEEDQFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARQTRAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGKDHESIMHAADLALYRAKMGGRGILAFYDPLMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAASWAPHLKVAVNVSPLQFSLANLGHVVCTALMQTGLSPNRLELEITEAALLKDRKAT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVRPNTRKKHPV
>D0SV00|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii SH145|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A290HBD1|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MFTLKDDRLSKIKNSILTRVILFAFMIIIIGGFTRYYLSFQTIHTNLFKVLSIHLEALAD
EGAQDVTHNLDVRKSFLTKLASLLPPSLLEDPKALKKWLTEREELNPIFSGALFVLNKEG
TLIAGNGTEINEGEKAYAEDDFFKQAMTQAFVIGTPIVSTISKVPVLPLSVPIKDNLGSI
RAIMVGMTNFDTPGFFDRVLNGHIGQTGGFLLVDAKKQIFVAATQKELILKPTPKRGENL
LHDKAIAGFRGSGITINAHGVEELSAMTSVPNTDWFVVSRIQTKEAFAMEENIKTTLIQA
HAASLIIVPSILFAFLFLFFRPLRTSASLADKMSLGEVPLKPLPIKRMDEVGYLTAAFNR
LMAMLLESQKELKEIAHYDYLTKLPNRFLMVDRLEQALARCARNNTRLALLFMDLDGFKA
INDSLGHNAGDEALMEVAKRFSSLIRTSDTLARIGGDEFVILLSDLDGDLSCATSAASLV
VSKCTEALKEPVILKGNRRYLGVSIGMAIGNKESLLDDLMVEADTKMYKTKNKTILRENA
ISSSVNLPSQ
>A0A2P8APX6|diguanylate cyclase|EC 2.7.7.65|Micromonospora sp. MH33|TrEMBL
MSERRRRALTSAALHAVSHAVAVVYCLMTLTGPNRPLMLTAYGCGLAAGVVGSWAATRVT
TKASGYRVSFTLLMMTLVIAALGAHWDGGVTSPAALGFVTTAVFVAGYTPHLRLMVGLEV
LTVGSYVVVAVAGPPAPAGHVFVYLAGMLVLVSVCSTQTRALARQRSQLRALASLDPLTG
ALNRRGLAELATFLFTGCRPGPSLLCLDLDDFKLVNDRLGHAAGDDLLRRVVATTRNVLR
AEDAVARLGGDEFVVVLGDADRDSARAAAARIEAAVRGLAGVSVGSATALRLRLAGDGRD
RPGTGVRTRLP
>A0A0N0GNF6|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MRKLINPTDVARETFKQLAVRRIPPTPDHYEEIYHGIAGTPEEERIPPLAKQLEDTLSSL
PRQSPELSRSLDQLRRCIRASNWEKVTELAIRCVELQGGQTQLARGWAELIRDLVKQWDL
RNPNYTAARKQDALERVLINFGGDPSSLNEKLDGLVRAWGETGTPSDGLGEADEAVQPAS
SIAPMALDPAAPGGPASWAEWRESLSHALDLGLAARLTHYPEIAIEAAALAREADAVANE
GDLQKFMPRLKKFWIRLELSNSQETRLCDGLLSLLRLLTDNIGEIIVDETWVRGQIAVVQ
EIMAQPLDMRLIYDAEAGIKEVIYKQSVLKQGLREAQAALKSMMSTFIDRLGTISDSTDQ
YQQRITTYSEQISRSNNLSDLKVVLENLTHDTRSMQLDVVRSRDELVEARTRVNEAQTRI
DELEKELQAVSEKVREDQLTGAMNRRGLDETLTVEAARALRSGKPLGLALLDIDNFKKLN
DVRGHSAGDQALIHLVAVVKSLLRPTDKIARYGGEEFVLLLPETDLRESEAAMLRLQREL
TRRFFLHNNDKVLITFSAGVTLLAPGEIGHEAIDRADAAMYRAKQAGKNRVEVEVPPDTV
ASPG
>A0A1Y6KUE1|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MNEISLADFHLTMQVLDNLDAGVVILDETYNVCAWNTFMQAYSGISSTQIMGRSLFDVVP
DLPQSWLKNKIRSTFKLRMHSFSAWEDRPWVFRFLNFCPISSSSDIMYQNMTLTPLRSLS
GEYKHICLTITDVTDIAKNKNHLHESNKQLTHLSITDRLTQLYNRGHWENCLADAFEYCQ
QTQTPATLVMFDIDHFKRVNDTFGHVAGDGVIKVIADVLRRTKRQTDIAGRYGGEEFGII
LPGTSAELAGYFTERLRNRIEKETVFDDQRGIVKVTISLGVCEWNPKLSDYKSWLEKSDL
ALYESKKKGRNTTTIINCDDCYTDSKGEFILTAVEANTTIN
>A0A0M7HF94|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MAGSFGRIGVETGLSFSLPKWRLTRWLTDSGQHTPADIRAALIASLFGTLPIFAGGVINT
LMISGVVAWRRPEPLYISWLALEIVLAVVRVTILRSALRNAARGGNTHTDIYIVLALLWA
FSVGYGVFVTFLNHDWLAATLAGVSCGAMAGGICFRNYGAPRLVAAMIFLSLGPMCLGAL
FAGEYVTAIVFIQIPFYLVSMSIASQRLRRILVSTMLAERENERRASLDALTGLANRAGL
EAALERICASARGQDSAAALFYMDMDDFKIINDTHGHAAGDHVLKTIAQRMRAMLRVDDV
AARIGGDEFIVLATGIDATAALRLGNHLLRDAIQPITLADGTRVSVGLSIGISIISGADR
KAQSVLDSADAALYRAKAQGGRRCAVAGAPDLDEVRETGDAAATA
>A0A5P9B7B3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MPHTIDPRTGLKKRTLPLITFFVTFLITVLCFVIVAITQSRSLKANLNSFADHQTLSLKA
FIDNDVAYIGSGANFFYSNDPQHWDKFDRFAEQTINGSKSLIGLQWMQKVTADEMEQYTA
KMKALYPSFEIYTIPKHGPKTYGYLLEGEPAFIATDLYPNTEPNNQVLGFYSSRDRFKLI
VDNIRETREANISDKVRLLQDGLSRDLPKTGMLVYHPVFDGHSDDLLGVVIGVIRTTFYF
ENLLASTVGDLDVYVRVTDHGFEAEDAPLLFESEGFENVDGQSITKHIMLTNRQWTIDYK
INSYISFNGYLVLAGIALVGTMISLLLAYIVNLQVREKERLSLMLDKRTEELRFYANHDS
LTEIYNRRAFNKMLDSAIDSDTPFTLIGFDIDKFKAINDEYGHPAGDALLVHVVKLISTS
LKSGDNLFRVGGDEFCILSSITEREQLSSYLDCILNKVRETVCEHKGQQLHCTLSIGAAI
RVNEGIEETLQLADSMLYQSKVNGRNQVTIAGDLNT
>A0A4P7Z8R5|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. TSA2s|TrEMBL
MSDSTTPSTTEALGAVLDEHLRWIGQWQRAVFYREGRGGERSSAPASFQAWCQAASRDDL
LQQPAVQKLAALHEQMHRQARLILLKASGGELPTEAEFEGVVGRFEEFMLHLRRMERAFA
AAASGLDPLTGLRTRRGMGEALEREHNRYRRTGQPFCVALCDIDKFKGINDSYGHDIGDR
VLAATAAVISRGVRSFDEAFRMGGEEFLVCLKETRLEEGYEVIERLRVDLMRSPVVLPDG
RMIPVTASFGLVEAVSDLTVDDLVVCADRALYQAKNSGRNRVIRYGIDRPEPKPAAAKAG
RG
>A0A5P9BD02|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MPVKAFAKQISSTRDHRLLADSLFEYLSHLLDPHGIGIFVEPASLSNRTPMYQCGELASL
NNYPATFWTWVSQFDTADGVLPMAINTCNWDHFDALGGESFILMLDNCPSCRTYLIIQNC
AAERVNQTFRDGVDVLQLAAARWQCIRAEKNAAIEIKNRDTREAQYLDEINLREQFVENM
KLVHQVALDLSNPDSLDALYKASVEAVRDRLGFDRAIFMLLDMKKRCFSGTYGTDEHGKT
NSEHHTQYDLHQLESEYIEALSDDHTNLVIIEQAPLYTAGQVVGQGWNGMLILREGDKPV
GWIAMDNYINRAPITGYQKQMLESFGSLLSQIYIRKRQEQNIRMLHSSMVELSRCDNVSA
VCKSAVSFAIQHLGIDRLAVFLTDKECSYMQGTWGTDIQGNIVDESYYHSDLVERDIVAA
ARSRPNEVAFEESVPIYHDYNIVGVGWTAMTLLTSNTGVPIAFIAADNLLTRSSLTSQLR
EVIRIFASSLAEVLQRTMAQEELKELNERLEEEVKKRTLELQLANEQLDVISKLDPLTRL
GNRRMLAQVLENLNSTHFEPSRPNEKVVFGLILLDLDHFGLYNSVYGHTEGDSALRSVGK
ILNDHILHENDTFCRIGGEEFMLLMVDTCDSETKQRADSIRRCIEEAQIPHSESSTSDYL
TASVGFASLSASLDCLDFDLLYDMADKALYQAKDRGRNRVVSAFENSQIEATFY
>A0A5C5VM16|diguanylate cyclase|EC 2.7.7.65|Blastopirellula retiformator|TrEMBL
MESVTTIQFSTFLIGVTCGVFPLLAGLWIGIKLMRDHNPPTDTSGEVEKAALIMQRMSQY
MRGLAGDVHEQRDVMATIEERIGEARRTASGSKSLEHAIDLLKVMNDANDGLQERLKRAE
TLINEQTEQLAATLSEARTDALTKLFNRRAFDEELQKRWALWSRKRRPFCVMLADIDFFK
KINDKHGHQIGDLVLQAVAKNLVQTTRDADYVTRYGGEEFAILLPETDLDKANEAAQRIV
AAIQAETFREGAIEIPLTLSVGVAQVGDAADAETLVAKADEALYAAKTGGRNRGYFYDGN
RVVPIIKEEDVMVEPARDFREVCADLRSRLLEATH
>A0A378TMV4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MRWPQRWRQSDHYDWLSGYLHARELSTPARIMMSTIAASFTLSLIALLISADGPRGAVPV
AMMWTAAAGGVLATVLWARRWPSHAQSLFFGVVTNTSIALACLSHGNPLASLIGCIAFAT
SGAYFAFFHSTRLVLYNFAVAATVGLIMAVKLALDGHLALAAVDLWLVVQVNIALPVAIR
ALVNALSVDLLHSDRDPLTGLFNRRSFEHKTLGLLMAREGADAYLTVVVIDLDRFKVLND
TLGHTAGDRALVRVAQSLRALAPHTAVVARSGGEEFLIAYVSADREPGTHAQRMCDGIAA
LPSKVTASVGTACAPVDNSDDASHQALIARLTADADAAMYVAKRKGGNRVHHHAQDSVR
>A0A3G2FGH5|diguanylate cyclase|EC 2.7.7.65|Serratia sp. 3ACOL1|TrEMBL
MDLSAAQHPLKAKGTLFTHSLLSALIVFLLAYLCLTLSAESSHFTPLWFPTAAVIMLMFH
QPPRNWPLHLILCGIGMCIASFLLFGLSWFPVKLTLINLLEATVCTLLLRRILQPNDPLN
DLASWLKFVFCAVIFMPMFSALLAATVAPEPGETFWQPFSTWFISEAIGVLALAPIGLVY
RRSMLRTLNLFELLLVSLGTLVFSYLALLNLPFPFTFIILPLLWAAISLPRLEAFIICFT
TTLMITVMISLGLLHFQDRGAFLSDVTIYLPLMLILIPAHAMAMVMHAFRVEKEHIVESE
ARFRNALEYSAIGMALVSPEGKWLQVNQALCKLLRYPPETLRRLTFQEITHPDDLNADLT
QLQDLVDGHISSYTMEKRYIRSDGESVWTLLAVSLVRDPQGQPLYFISQVEDINELKRTE
AENRSLVERITLANQAGGIGVWEWILAGDKLTWDKRMFELYELTPDQPPTLALWSSLMLE
EDSERIGRQMATLTDQHRPFVMEFRIKTRLGGIRHIRAQGNTIFDEHGEPKRMIGTNIDM
TEIKSLAEALHEEKERLHITLDAIGEGVISTDRDMRITFMNPVAEQMCGWPLEMALGMPI
NGVVRMTNGQDGPEIENPVKNCLQEGPPLPAEYALVLHSRDGRRFDVQESVSPLKTIEGE
VMGAVMVLQDVSASRQLMKKLSYNASHDALTNLKNRTSFEKRLKGAIASAAENQQQHSLV
FLDLDRFKAVNDSAGHAAGDALLREIGQLMQRQLRNSDCLARLGGDEFGLILFDCSLEQA
KLLMQQMIEQVGEHPFCWAGKVYHVGASAGITPIGATSGKSSELLAQADIACYTAKHHGR
GQVYIYEARQKQQMERQHELLTRQEVLNIIDDQQLLLHVRAASPPKTPQAVCFYQLKLHV
RPPDDRLLASESFLAAAQLYGLLPDVDRWLVSQVLERHGEALRRKGLAIALPLATDSVLD
LDFQNYLLELLAASVLPASALYLMVDETIVLDHPEDGGAFIRRLQQMGCKLIVNGFGRNL
NAFDQLNGQTIDYIRIDERFITDVHCNQMDELMVSMIHGAAHRINIQTLAGPAHQQVTLS
ALTAIGVDLVDGDTVALELPLSDLLSGGYFGIH
>A0A1V5PSD7|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.Bin346|TrEMBL
MNIYIFLLILTIVISVGNSTVAFMRRGTPGAKTLILLNVAAAVYAFGYIFEITVKSLDVK
LIWYGIEYFGIAALPFLWLFFALQYSDNDRLIINKRIFYLAVIPVITLIMVWTNKYHGLM
IKNIAISPGIVHEISKTAGIWYWVNIIYSYGLTIAGSIILINTVTKLPTAYIRQGTALTI
GALIPIVGSLLYITNSLPIGELDLTPFSCAISGILFLWSLSMQKTLQIVPIARDKVFDSI
EDAVIVVNTNGTVIDFNRKTREIFGISENELISQNLEIFLMTKNIRFNLKDTGLKTESPE
ICNNGVKSYYAITSLPVEKKHGKLTGYLVVFNNITQAKLAEKTLSESKKKIEGLNRVAYE
LSMINVDEEVYRKSSISAKEMMGFSYFSLFLKKDGLLTSSYNSSPELRALLSDKDFYNDC
LLKIFNTKKTEIRSVNDFPESLRTSLKGVLQIHTALCIPVSDIGVALLFGDREEVFSNEN
IRLAELLVGHSSESLKRIWLQKSLREQAELDSLTGVHNRRYFSSLIEKEIERSKRYNYPV
TLAMIDIDRFKEINDRYGHQVGDEVLKGIAEVISSQIRKVDTLIRYGGDEFLLVLPEAKG
KGIEAFISRLREAVSLWSRESRLVDFEIEISIGISCYDPELSEPVDKIIHYADVDMYSNK
KQKKFK
>A0A6V8LP91|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MLFTTVRAKFYLLYVCMVLLLATIAFIATIYSWNSYTEKQELLKEYNVFRLSSTVIHMLQ
KERGLTVKSLFRPTRSNIDELKAWRAKTYSAIVEFHGTQFSQNLRATYAGLHNLVDSKAI
SPENIFLQYSDCIYEIISAFGSDRSFEHIQHDHLFLSLTNLLMAREHLGKIRAYISVLAS
NHHVDDVGFFYVKEKFGFYKVSKMEFLKSLKSKQPLYASMIVESEKVKKTDEAILLFLGE
KQQGFDYDGWFDLSTGAMDVFYDVEKELSGVYGAFLENEIKKTKVYSLIVLCVTGVVVVA
SWFYVANLMRSFSSRVENIDAKMKLILKNNDYGVEITDPGNDEISNISNSLNSLLKFTSE
LLEEKEKMASTDRLTGIYNRTKFLDIFESEFQRFSRYKTTFSVIMVDIDHFKKVNDNCGH
NVGDSVLIEVTSLMSKIVRATDVLVRWGGEEFVVLATSSDLQAAVSLAEKIRLAMAEHSF
ASNLKVTMSFGVAEIEADDSLESIMARADSALYESKRTGRNKVSAISTIK
>A0A2H6JP68|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin14|TrEMBL
MTSLFSNPPPSILIVDDDEVLRLLLRQFLEGEQYTVTEAQNGNQALQILTRTVFDLIIMD
IAMPGIDGPAVCEHIRSLLPDPPPVLMITALDDEESVDQSFRAGAVDCIRKPIHWPVLRN
RIKYILAAHRARLELERMSRNYEMILEAAANGICGVDKDMRISFINPAALKMLGVAQDEV
IGKKFHEVFKVSLAGTDDFTLDCCPFLKNSTQTSSFHYDELRLLRKDGTSFPVDCRATPI
FEGNTVTGGVLVFQDVTERQQAAELIRYMADHDSLTDLPNRNYFNDRLPQAISLAKRQGR
MICLLFIDLDRFKPINDKYGHSVGDLVLLQVAERLKKTLRVSDSVCRLGGDEFVILLEST
KSVEGAKNVAQKTIELLNEPIEVEGHKCSIGASIGISIYPQDCHDAKTMLRNADIAMYEA
KKKGRNRFELYSSVVEQAGEEIQ
>A0A376F3W7|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MTASAHEAGDQVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLPGADEPEAHALRAEDLQ
>A0A5C5YRK1|diguanylate cyclase|EC 2.7.7.65|Posidoniimonas polymericola|TrEMBL
MSPTVLITGMLLGVLQLAVGIAVGYWIAGSKKSASTTEDDRRRAQRLAGELRTLTADLSA
EARRQGEQLERVDDRLQSESRALSISPEDNPLTALVSGVIREMLQANQQLQQRLMTAELE
VESQAAEIAEHLHTAMTDPLTELPNRRAMDDHLSMRADAWRKHKTPYSVVMLDVDHFKQF
NDTHGHAAGDEALKTIASALREALRQHDVVARYGGEEFALILPHTSLQTGQSAVHKAIQS
VRATTVKVGGQSIPVTASAGLASIAAGERIESLMSRADQALYAAKQAGRNQAWLHDGAVT
APLSPPDSEPQAAVTPPELNADLKDACSALTDRLGSLLNPDSVGVGP
>A0A5B7UVP6|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. YIM 121038|TrEMBL
METESEPYVRLATLRQLHQVVADLNTARSLADTLQTVADGVVNGLGYELACVNLVRPDGD
LVVAAFAGNPAAEALITGRVGSRESWDRRLAMGEAWGALRFIPHTEGWVLDEDDVPQWYT
EGPDPRFEDEWHPSDRLFAPMYATGGSGGELLGVISVDRPRNGRRPGAWGREALQMYAFQ
AAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRIL
RTNDALCRLLGRPASAMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRFGRRDGTYVWVSL
RNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDSLTGLPNSAELRARLSARLCR
RPHAGRPSTVDSLDAAYDNSGLYSGAAGHPAGHGHAAPPGAHHGAQGDFDHHVHTVAPPE
ETEADDGTKGLAVLFCDLDGFKSINDRFGHHTGDAVLIEVARRLTSGVRDGDTVARLGGD
EFVVLADGLGRADAQDLAVRLRNAIIPPIRVEGRAVRVGASFGIGWAHCGMSADEVLHSA
DQRMYVEKRSRAKQHRRAG
>A0A509DRU1|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MAFQEEQKKAGLVGVLLLVTTLAVMFQALGIEKRFVIDPSSDISYDPLDDRPLGGKSVAT
VEVVDNKFVVHCEIVKSSYEWPFCNLAFRLNDGIKGTDLSGYSYFKLWIKYETPQDSSIR
FNARNFNPAYSSLDNDESLKYNTIEFYEKSSSYPLVVPFEQFQVPTWWLVWAGLSHEDGA
NDFSNIFSLVVGTGYVVGPGDRSFVVERIEIIGELISAQDLYFVLLLVWGSVGLIYFLDK
IFSMKKEKAGQEQEYEALSKLLEAKSEELSHPLSRNPETGALDNDSILDLFKSTARSETS
IQLSMMFVGVDNFSTLKDKYGESMANDVLQIVSQILAKNIRSSDIVARWGEREFVLILPH
TELAFASQLAEKLHVLVEKAEWPENLKIYASFGVAERLDETPTSFINRATKALNAASAQG
GNRVVTATEHMVEISRE
>A0A6X7XDI6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAVVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379WZ45|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRLAATNLR
>A0A379WV28|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MAKAIKTSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAG
IYNMQPNDTINDAYQASDAQLYLNKQQKQHRSS
>A0A3V6WWI6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDLPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F6MPY8|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWLLFSWDAISLTYTTINIIEAGIGAVLLRKLLPWYNPLQN
LNDWVRLAIGSALIPPLLGGVLVHFLVPSAEPLRNFIFWILSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVITLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLVFL
FTIMMVSLMMARNPASMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQALTFQQLTWPEDLNTDL
EQMEQLVNGEINTYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWSLWHDAIV
PEDRTHAEQVLRESLQARMPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSYDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEAELLHALDRRIFSEFFRTYARQVAAKGMGVALPLSEAGLASVTLV
DELFDLITKGPLPARLLHLAIAVDVLSNKDENVQQGLQKLRHAGCRVVLTRVGRDMNAFS
QLSAHTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A7T9PE57|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAIKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKKTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A7T1QX17|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDTHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSREVVNLKVDAIVAGVWMGLTGCNALPAA
ALIVMIGMNMMGSGGCRLFLSGVALLALSALLTVQFTGTPVVLTSEPLTLWLTLPVLMVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFETCRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A0U5ICQ1|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MKDLIDIDVLTNWVSMLRAEIDGAILLADDDREGPFYEKCAHEKARVVPSAAVARRLLER
IQMRQVAGVVAVVSATRPEVDVAASVFQPSLGDIASLLLCSKCCEGVLEEIGGAAWVRAC
DKEVGSLTDRVVALAWSLQQFFVSEGVSLAQAAVSSLIDWSTLMFSDSDVANKFGPTSAR
SARSLLTESLAKSRVDLLRECDGMMAMELLACATREFHPRGLRSSRQSTTSDLLGMMRLS
FDLADFESEYMYWRMRAWERANWKYPLLKKWRHLDPLQVVLDQRYWESDLRVILANDSAQ
LGMTAVKLDLDNFKSVNEALGHSGGDDAIRIACRTADAVLSKVAEVYRRGGDELVAFAPD
FRGAQADELAEELRKSIETEFESWGREKGLESTPTASIGLVDVAPGSCYDDVVRLMDESQ
QRAKREGKNRVIKSCCSFESSGR
>A0A3Q0MYD9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLGNEQ
VERQLKSAMERWIINVLSAQVDDAERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A827HR73|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSQGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVSL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGHDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A2H9DQL9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTER
AKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNEIYRLADNALYEAKE
TGRNKVVVRDVVNFCESP
>A0A8B6AY65|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEPWSVLIWR
>A0A8B5NCW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSASLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8G1WDE1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGDVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A775TKT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETSRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A447XTD6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLTLKQYAQKNLALTAATMTYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNI
LASWHYTRKDPGDTFSNFISHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLA
VLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFA
LDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLIGLANRAAFRSGINTLMNNSDARKTSA
LLFLDGDNFKYINDTWGHATGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSE
SEVQRICSALTQIFNRPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQ
RAEKLVR
>A0A5P0JEG2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGTWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNST
>A0A5F1PZ86|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERTAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8G8AMK2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTLNSTHQRHALVFID
LDRFKAVNDSAGHAVGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A2X7FPN2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMVALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A8I0TKN5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
AAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVL
CALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFT
VSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8B5FAT4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGCIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A826Y6Q2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQRVLITLPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGNIAASVLLFSTSSLNMTWTAINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPVLGGVLVILLVSDDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPTLLATPRTYLMSHVPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINDLKRT
EQINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEISPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQARLPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTALQITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLTNRASFEKQLRILLQTVSSTHHRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAINDYHFMWEGRVHRVGASAGITLIDDSNHQAADVMSQADIACYASKNGGRGRV
TVYEPQQTAKHSEQAMMSLDEQWRMIKENQLMMIAHGVASPRIPATRNLWLISLKLWSSE
GETIDELAFRRSFSDPALNHALDRRILHEFFQQTAKAVASKGLSIALPLSVAGLSSAPLV
DKLLEQLESSSLPSRLLHLIIPAEAIFDHAENMHKLRLAGCRIVLSQVGRDLQLFNTLKA
NMADYLLLDGELCASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSGMGVD
LIYGDVIADAQPLDLLINSSYFAIN
>A0A8G7XVM1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMAHGVASPRIPEARNLWLISLKLWSCEG
EIIDEQKFRRSFSDPALSHALDRRGFHEFFQLAAKAVASKGISIALPLSVAGLSSATLVN
DLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKAN
MADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDL
IYGDVIADAQPLDLLVNSSYFAIN
>A0A3A6T9Z1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGYQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A377ZJH7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MTIIVLSWLYSSHSPWLSVNFIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRN
IFWFSGAFFCSAYLFTLFQLLSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRES
NHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYG
HVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGE
SHLPERMTISMGVYTTHDNSVTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A377BBF3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLRLAHNTSSMVEQAMYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHR
AVRWFTSQPEHASNTEPQVTVSVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEY
QLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAMEHDTRGGIRMDSRYVSWKRLDHFDG
VLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAW
HDTLTRLYNRGALFEKARPLAKLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHA
AGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAEVRRTYSPEVK
>A0A6N8QLB8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
SQRNHLENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAW
QIELNRRRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQA
MYVSRAGFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNT
EPQVTVSVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNP
DHPTGNIFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGD
FGSISIALTLLWALFTTILLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNSGALFE
KARSLAKLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAG
RVGGEEFCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDY
DFEQLQSLADRRLYLAKQAGRNRVFASDNA
>A0A5Q8AN11|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
TLTLLWALFTTMLLISWYVIRRMASNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARSLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAK
>A0A7H9LUD1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHKKTTEIDAILLDLNKAIDAHYQWLVNMFHSVVARDTSQPEITDNHSYELCQFGRWLDN
LGPLDSDELPYVQIIDSTHQHMHNCGRELMLAIVENRWQEVHFDEFQEGLLSFTAALTDY
KIYLLTMRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRSLATYLAGWTRDYDTVYRYGGEEFIIIIKAQNDDEACRAGVRICQLVDNHAIAY
PGGHIQITVTAGVSRAFPEEPLDLVIGRADRAMYEGKQTGRNRCMFIDERSVIARV
>A0A6L7CQ31|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
LRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIF
EGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFY
GYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYA
>A0A484X439|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKLVQSGSSVMFIA
IDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCIILVDSTPQIAA
QLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNKQNKNSRS
>A0A2K4P9F2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILS
>A0A376VIL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPIPSPHKRTAKI
PLRSAKPTRYYRNPHRSAQ
>A0A484WNU2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLGISSTVLVSLLFGLALVLVNSWFNQPTVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFIKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGADSCSHTF
>A0A377K5D0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNEN
ADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKK
HKQKTPFVTHSALHS
>A0A4U9TRH9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNAPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A376TLZ1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVM
STRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIV
ALTRQLQITSAR
>A0A376V7U5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2J7Y873|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MKPTRKRTVRPTLRSVLGRGHLSVALLAVGLAGISLTLLGVLALRVYANHNLQLIARSIN
YTVEAAVVFDDSAAANESLALIASTEEVAEAKVFNNEGEQLAHWQRDNTGMLAQLEVQVA
SALLDEPVILPIVHQQQQVGHIELAGQGRSLLLFLLSGLAGILFCTVLSALAAQYLSRRL
LSDITRPLRGLASVAHAARRERSFDRRVPEAPIAELNELGNDFNALLDELEVWHSHLQSE
NQTLAHQASHDSLTGLPNRAFFEGRLSRSVRNAARQQDHLALLFLDSDHFKQINDTLGHA
VGDEVLISVAERVRAQLREHDLVARLGGDEFAVLLTPLHTRKDAEHIAEKIVASMKLPVQ
LDSGRSISTSLSVGIAYYPDDGADPASLLNAADAAMYQAKRERRGHWQLAQTERSANEIR
NRS
>A0A1S7LKI6|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MKLTAKTTIFTVVLTVSLLLVLLFISLFAFRHFSISNAREHARTAAEIVRVSLTESMVNG
VIDQRGRMLDRFQHIEGLREARVVRGASVTRQFGEGLSSEEKNLDQIEMQVLADGNPFYG
LLEEGSEPIFRATIPYIAVRDSTPNCMSCHQVDEGTVLGAITINISLASQRQQAMMTVML
MILVLTGFAFITTVIIRGQIKAIITTAEGVSDVVQRANSGDFTGRLELAKVRKDEIGDIT
RDLNQMMGHLQATLGGITSDVAKVIQYDATQHSNLLDTTGQMVETLVKVAQFKQTIEEDR
TPTEVYRHMGYMLTEEFDINHYSIYEVQPEKDHIITQVVDGETNAECRWCDIQILAQAEN
CRARRSAGGRVVDGVETVGICNMFAPDVEGSRQLTHLCVPILHSGSISVVVQLVVEKEHA
PFYKHMLPFIQVYLREAAPVIQAKRLLNTLRDSALRDAMTGLNNRRFLEEYLDTMMASAK
RQNHTISVMMCDLDHFKGVNDTYGHDAGDAVLIGFAKVVSAQVRASDMVIRYGGEEFMVL
LLESDPAQGNGERVGEKIRDAVSKMKTPVGGNVITNTVSIGMARFPQDGEEFWEVAKLAD
LALYKAKREGRNQVVVFEPHMKQEADELVDKKAKGPAPRGVEDKSAATTEQEPTDDV
>A0A109C122|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MDKTRILIVEDEMISGAFIQNTLEMLGYEVTFVAISAFEAIREAERNRPDLILMDIKIKG
AEDGIETAHEIRMRFDIPIIYLTAHSDEATVERAKVTEPFGYVIKPVDSKELKTSIEIAL
YKHKMEAKLKSLAHYDFLTGLPNRTLFFDRLDQALKQAKRHNKDVALLMIDLDGFKCIND
RMGHDTGDMVLTEIAKRLKHQIRGTDTVARFGGDEFIVILTNLANAEDAETLALKIIVAI
GRPFQFKTPYCAIGASIGISFFPKDGSDVETLLKKADAAMYRAKENGKNNYQLFHDANNK
TNIDIKTVLSHSLQFILKNKSGWGHNEWLEFLIALKEKGVFISKTVEPYVGVIVETLKKF
CQLTPPSAGSIEKVLSHVCDKAADFIVSNNGIWTIQDWETFLNDINSTGIMLDKEAALLV
LDIIEAAKSLHILCP
>A0A2J7YHC5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MTNLDPGDEIAYSVRRDRLEQLFVQSAPAVLGSFLAAVMLCWLGWERFDPQRVIVWMTLL
GLSTGVRTAMFFAYLRAPANQRTAERWEWRYWVTLMLSAAIWGWGAFAVMPTDDALGQTL
IMLFAVGMSVSAVSCYSSYRNMTLVSMGLVLLPSTGWLLLQPSTLQQGIALAVLVFAWFV
VSATQSLSSALTTAWRLKHEMQRAHRLAMVASCTDELTGLNNRRAFFDNASAQHVQCRDA
GTFMAVLMLDVDHFKQINDTFGHAAGDQVLQRIGAAISASLRDNDIAGRLGGEEFAILLP
NTPPDTAIEVAERLRALIAKLRVNDEHPVTASIGLAFAKAPATELGALLSSADSAMYLSK
VSGRNRVTVAEPEQETLHKQH
>A0A7V8PZX2|diguanylate cyclase|EC 2.7.7.65|Pectobacterium brasiliense|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQDASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLIHHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRGHSTTTLLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPEE
>A0A1V6AP43|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MENRAEYQISSSVNEGILEISITGNAIGSVFENMSNEVDAIIKANNSKKVIIDARALKGR
LDETEIYRYVRNHHSVIYEIEAAMVDIPENDSYKNAIINAGLRFEWFYDIDAARAWLRTL
SEERLRILNDLVDIAPASITVHDFAGRFLYANQKTFDLHGYSRKEFLSLKLQDIDIPTSS
ELMAARMEVIRQNGEAAFEVAHIRKDGTILPLWVHAKLGKWGNENVLFSIATDMTEQKRR
EEEIERISRLLAETEAVTRVGGWEYNAATGRITWTDEVYRIHGVGKDYDPNNVTKNISFY
SPRDEAVIERNFRRAVETGEPYDLELSFIRASGERIWVRTIGKPVMENGKVVRVTGNIMD
ITDRKAVAEALKESEEKFRTIVNNLQDVVFRADLNGTITFASPSAAYTLGCSSTEEIIGL
KISSDFYFDPNEAQHHLEMLQRCGKVTGQEIMLKRRDNGQPVIVSANIQFFHDNAGNILG
IEGVYSDITDRIQAEKEREKLIRELQKALKEVKTLSSLLPICASCKKIRTDEGYWTQIEV
YIKDHLDVEFSHGICDDCLKKLYPDLYEKMQHDDKP
>A0A741N1K2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae serovar 41:z4,z23:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A377HPA6|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MFSVLASVIWFYISYHQEVNRSRSQIRQVVATIEQTASIAMFLGNKELAEEVIRGLEAND
TISAARLTSQEGLSAFFSDNSKHGQHYTAIIFPIVSPFNKNEFVGDLLVYPNQNYIENNA
ISLAKIQVIVLVFYSVIIAFLTLFIVNRILTEPMKNIANRFHLITPGDTTRIDVPVSHKD
NEIGALVSDINGLLDAVNNQIENERELRANTENLSKKFRFIFERASAGIGLIDANNQLIV
ANPALLRLLGQTFIVDTDRFSKTDFTRYFDNPAEIKEFIEEFWSKPGNQFSAFDIQLKHK
VRASDRWVHCLFSKVEDINNPDDSLLEVVLYDITERAEREQNIIYEAEHDPVTHLLNRRA
GMTKLETSLQEADRKARKFAILMIDLDGFKHVNDNYGHDAGDKVIIEVAKRIKQFFRGSD
VVARWGGDEFLIGFSYNANYETAVSDIASDLQYQIARPVDIGHEQTAGVGSSIGISLYPD
NADTISSLIEQADEAMYFIKNNGKNFFHVYTGEEAVAPENR
>A0A1F2PMM9|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNETINKELIPFQKHFDAFITAYLTERDLNKTASLFAESFLGFGTGLAERTYTKAEAMLL
FQQDIESAPNPIAVTFHQKQFLLLDADNALVAAELDMKTVILEQRVKFNNLRLLLVMHRN
QDTVAIVGMHLSFPTDVHGDEESFPLKELEERAHLLQEMVEKRTKSLKQAYDELSDLINR
DRLTKVASRHYFEEALLNEQRRFKNFQRNYALILLDIDDFKQINDMNGHLIGDDILKTVA
ATISNIARKTDVVARWGGDEFVILLPETGVDTAYELAEAMRQAVENGDYPITLAITLSIG
ISGSRADDHARNVFKLVDDAMYRAKKTGKNQIVCV
>A0A1F2PGW3|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MEDTHALIAYLNALLDGKKPPLPAGYADDPDFLLLIEKLGHIEAFVSEAQKTDTGDICDL
DELIALKKKLKESEEHHRLLIENASDIISTVNLDGEFTYISPSVERMTGYTVDEVTHHFL
EINYFLPETLKVMERTMALVRQTIARGQRFDSVRFEQMQYTKNGQAFWTDTVLTGVYDDQ
DQLKGLLGVSRDITEQVRLREEIIRLSQTDKLTQLYNRSRIEDLLEDEYKRANRTDSTFA
VIFLDVDHFKWVNDRFGHQAGDLILNELSTVLLDNIRQTDRVGRWGGEEFVFILPDTDAT
GALLFGEKIRLKIARHPFTNPTHITASLGVAVYQGRGTLIDLLARADDAMYAAKKAGRNQ
VQLG
>A0A564WXG8|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MKTIIKYELVINEALRSALNYNTPDEQINEFIRFFGRHIGSDRIYVFEDCKERHGTDNTY
EWCAQGVIPEIDRLQNVDMDVIKWWYDTFSKGESIIITDIEDIKEEHRASYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKSDYRGLTTFLDMIGTLLISFLKLRNSFIKSNKEAKL
SSYSSLSKIYASMYLIDVQTKRYHIIKMTDQIAEYLGKDFKMGEYEIRDDFCGHIKNIAE
KMCTESQLQESLEFVDISTLEERLLGENSITHEFTDKISGWNRSRFIPVDYDEDGKLLHV
LFCIECIEEEKKRENRLIYLAQTDLMTGLCNRGSGEKKITEFLKEKTGGLLCLIDCDKFK
SINDNYGHSVGDKVIIAIAEKLQKTCRDSDVVLRLGGDEFAMFIPGMLEQRVAEKFFERF
FENIRQIDIIEMQGKNIEISLGACFYDGYEEVSFDQLYRKADRAMYQSKKQKGCSAVIYG
EEM
>A0A8G0TY88|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MKDSNATVSQLALLQQKLHSAKLALDEVNEDRNAKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHNLSTFERIDEALPELVDVERLLKGQYHHVMVQLEESRAGLAQVVRQIQRVNSAP
EKLKKEVNYFKQDLSKPFHTVWEYIPKVKQIIGFYETILQQQFSESEKLEILPKHRQLAH
ELAHMISEIEFRKDQRDQVLVIKEMLASDIEIDNLLEAYQTILSLLLDNIAREKSASQEF
LYALNDALAAVREVVSESYNHTQRSFQLKTQLNREINTRVDNAGAIILDVEDVVDLKAKL
TEQLNSIRSALARKEALEQREQALLRKSMETMRKELNELSTEANTYKERLFEQQKLNLLD
SLTQLPNRAALEERMELEYRNYQRHKSPLWVAVADIDHFKTINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLLLPDVGNGDIVQLLNRVREKVKNIPFKFKNQRITVTVS
IGAAQVMGNELIHETFERADAALYKAKHESRDRVVIDV
>A0A0J6C525|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MTVKSDLDRQIADLLADPAYEGHPLRTALETLWLQANEHMARIERITQISDAYQSMALRR
EQGLYERFDRQLQRLARIARISDHYQNMMRDLNRTLEETSRRDPLTGLLNRRALMDIIRL
EVQRSDASGKAFLVAMLDVDHFKSVNDRHGHETGDRVLVELAGVLQQSMRASDHCGRWGG
EEFLLLLPDTDLAAGQLAMDRVVGAVRALSIAVGGEALRLTVSVGMADHLVGETLSDTLS
RADQALYLAKHDGRDRVALPGVPRQPSAGN
>A0A448W1Q6|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MDYRKKKNLIWKGESFLFFVVLLVFGAIFAAIHTGGLIQKQDSVQLLNKGWYYIKDGKKQ
EITLPAEIPAKTGEKLILYNESLGAESRGMTVVSTGAQYDLVIRLNGKILYEYKEAMFSK
NVQMRSKVQCIAALGNDTEGKVLTFSYSAPQRGKYVIEPVCIGTGSAIAWYQIRKAAIPL
GAATIMIVLSMIALCICIYMRIRQMPDRRFRDVALFLMMCSIWLVTDSSLAQSYSRCPEV
LCLISFYMFMLLAVPMLRFLQNIGNMKKYRLLDLGIFTFYLNAFLQGVLVILGAFEFKDM
LFVTHILLFVWALISAVLLIREYRKHKQREIHLLLIAYIIVGASGIIALILYWLFEISYY
GSIFELGNLVFLVLVIADAVMMMADNVRYRLESQAYERLSREDGMTGLETRANFEKKLES
ISADMGRYRDILLMYIDIDQLRVINEEYGRAAGDEMVVISARCVENVFQEKGTCYRIGGD
EFAVLVYDPEVPDEFWSERLKEELRNIGRGCRHRFSLSLGCSHLRNKDGSLKSMGEWKYE
ADRKLYENKKKGDLKNGVY
>A0A1V6CJ24|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin135|TrEMBL
METTRDFFQGTEAAPILTRNDNDTALANPEHIFSFLSLTQNRAGDQPMSIAPFKFRSACK
RAPVGMSVVKIDDGKVLLSNPAMQNLLGYSRQELIGMPFSQFTHPEDVEKQKEAYLKIKS
GKRVSFDLKKRYIRKNGTSFTAHLVSTLIRRSDSKPQVMIEMIMEEA
>A0A1C5QBB8|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MHLGNVQAVIMADCNYLKQTNDTKGHEFGDMLLQSVADGIKAVLPEKCIAMRVGGDEIFM
VCPHTSKEKAEVLVQKMKEQMVKRSDEILQVSVSFGISTVENGEATFEEAYEEADQEMYK
EKMASRVGRE
>A0A1C5XV77|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKDRRKNKRKRKVLLTLYLAVCLVIIVAAYFHLSRIARNFNTEHLELITGLYAEKMNDSM
EYLQNYVQEDIKMIRSMENAQPEEILEQLEKNLDKTVFGDIGFIMNDGEIYGSSSCAVSD
IKKKKLDEAALASDTSFNSDPYQSSRTGNMTMTVFVPVGDTSLVHTLYVSIMIENLRQLG
EYELLQGKISIHLLKADSENFITCVSDNSGPSGSWNNLLLQQKYFQYDAGYSYNQWIKDM
RSGKKDGRFSAIIRGEESTISYRSISVMPGWYVIVELTNKNISDITQQFSAWGGVYGSIL
VGFTMLYMLTLVLLEKKDKKMYMGLSTTDPLTGILNRRAFQIAVEEELRKKTPGIFIFID
VDNFKIYNDTYGHNNGDFCLKHFAKTMKSCFPEDSIIGRYGGDEFVVYLKNLTGEMARTY
METFQRMISQLTLPTGEVVELSASAGGAAFPEQGEDVMSLCKSADMALYKVKQNGKADFK
MKGM
>A0A1C5TIN7|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MEDRNCELLFEYLRSILYDSEVKPLEIDSLDEPFQKLGMGLQYLETAVKEMKQCSAALSK
GDLSSFKPARENFLCENLKNIHANLNHLTWQAKQVAKGDYSQTVSYLGEFSEAFNTMTEQ
LREREKSLKLIAEQEKKHAEMAESYSQLLMELIARSEKEILVISLDGKSLLYSNRRTEEE
VQNWDVYKQWISQIGQKKQQEDRRKERYEWKWEAEDSTHRFYAITTGKMKWQGEWAYVNI
VQEVTETRVKEEQLKAEAYQDMLTRIGNRFYLKEKAEEILQTGEQISVCYCDLDHLKYIN
DTFGHQEGDAYIRFFVRIVNENIREEDVFARIGGDEFCILMRDCAGDDARKRLSDIQKQF
VLREKTNYARSFSCGIVGVPRNHDKVDLDTLLHEADEVMYNQKREHKKEYQSELGI
>A0A432X114|diguanylate cyclase|EC 2.7.7.65|Aliidiomarina taiwanensis|TrEMBL
MQRLVSERLKSDWQSLVQEQHAPHLNIITSLVEQHSAELARYFYANMLSDDDASTFLSHD
EVKQRLSKSLQRWLINLFQVPENYDLDATLQQQVKVGEVHARIKLPIHLVLRGARCLKKH
FAELLQEQALDPATQVACFQLYSDLIDIAMELMSLAYTTSTEAGVRSEEIYRMYSIAQNS
AAERERQKAALLNWENKLMFQHTFGSESGQPSALRLCEFGLWFHHKGAHAFADYKETKLI
EQAITEIDSRLGFVLSEQQSPTEKLEALRFIRSQTQAIQFHLDELFTRSSEMDHGRDVLT
HLLNRKFLPTVMMRQIAHARAHNSRFAAVIIDLDYFKSINDEFGHEAGDSVLQQVSQLLM
SACRSSDFVFRMGGEEFLVVLVDIEEEAAFQVAEKLRKLVAKEKIHLPENKTTKVTASLG
LTLYSGHPDYQVILREADKALYQAKNNGRNSTVIYSKELN
>A0A0D8HKX7|diguanylate cyclase|EC 2.7.7.65|Acidithrix ferrooxidans|TrEMBL
MNLAQPTRVAHPISKAFEAIASSVQLILDHFGLDGGFLLARQSFSRSQVSGVILRKFGRS
FGVLNGDEVRIAPRYSQFQDNPTKVINPSSILASLLVLDKSEQPLWLEVNDAFHVGPIRL
MAALSIMPELHDLNEHQLIIYDTQQSIISSEEISLALLGIGPLVAQIIADGYIAARREIQ
TSIVLSEAERDPLTDVLNRFGWERAIDHLRSEKPGSIYSVVTFDLDNLKIINDTSGHSSG
DRYIAKFAQVLKNAVRDNDMVARVGGDEFAILAPKMNASSARDFSLRIEQQLIAAGVSAS
IGHASGMTPFSIERLLEESDRMMYQSKRYKKTIAMTGTLF
>A0A6J5G7C0|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia caffeinitolerans|TrEMBL
MTQPAPPVSPPPTPRPTLQAVLRRAHLRLAFVAVTMATVSLIMVAVIALRAYSGNNLNLL
ARSLGYTVEAALVFGDRVAAAQAIELIAKEEDVAEIVVTDSRSRPFAAWQTPAASAIARL
ERAVADVALPGPVTVPVLHDGIVVGYVEVRGQGHQFFGFLLGGVGGILACLAVSVLGAYV
SSKRVVRNIVAPLGALAGVAHAVRRERAFERRVKPAAIAELNQLGDDFNALLDEFEDWQN
HLRDENASLEHKATHDALTGLPNRLQFEARLKCALSEATVTDQRVAVLYLDCDRFKEIND
CFGHDAGDAVLIGIAARLRTQLCEVDLVARLGGDEFAVMLAPMRELASAARIAEDILSGM
TLSITLSDGRTVAAMMSIGIALYPDHACDANGLLRAADAAMYRAKRARPGSWQFAEGIAG
PA
>A0A8F5G2E4|diguanylate cyclase|EC 2.7.7.65|Crassaminicella sp. 143-21|TrEMBL
MDKEIQILVVEDSLTQAQQLKFMLEKRNYKVIIANNGVQALEYIYQYMPDLVVTDVLMPK
MDGYELCKRIKEDDRFNHIPVILLTSLSDPNDVIKGLKVKADNFITKPYNERFLLSRIQH
MLVNIELRKNKISEMGIEVFFAGEKHFINSERIQIIDLLLSTFENAVQKSKELEEANNEL
KKAFETIRKLEKNYRGILESNIDALVVINRQKEILYLNPAAKKIFGEKYEELTFDILDFS
TIKNGVKEITIKTMDGNQIIGEVCISETDWEGKEAYLLSIRDITEKVHLREKLKIQSLTD
ELTSLYNRRGFFSIIRHKFEFARRNKKGMLLFFIDIDGMKHINDNLSHNQGDCALIGTAK
ILKNTFHENDVLARIGGDEFVALSIDVKKQDIEKFINKLLDQQRAFNEESNYPFNISISI
GAAYFDPENPVSIEELMARADKLMYEYKKRNHLCL
>A0A7Y9A0C6|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MLKLLFANAAMLISFLYLGSHILNDEFIKSNSKVKFKLCFGMLSGLSGCVLIFYGINLTH
NTIIDFRIIPVIITSIYGGFISTFISVFIIILFRLTFFGINYSSLITSGNLFILLIIFTI
ISRYKINFSKKYFLMTIVNIISTIIWISLVLKDMNLILPALGNFVISIIMVSTVVYYELN
YISKTNKMYKKLKFDSRKDFLTGLNNVRAFNGLLDKTIRNTLQKKENLSILMIDIDFFKH
INDTYGHHSGDLVLKQLSKLLIDSCRTFDIISRNGGEEFTAVLLDCNYKHAVDIAEKIRK
NVECNTFKLDNNATAKITVSIGISSYPDITKNINTLLSKADNALYLAKRTGRNKVC
>A0A0K2P475|diguanylate cyclase|EC 2.7.7.65|Cronobacter dublinensis subsp. dublinensis LMG 23823|TrEMBL
MPDKILISRWRTKNPIRVVNLCFCAVFIFSTLLTWREVVILQDAWISSQRNQLDTIATSM
DRNLQYSVDKLQFYRAGMRYTMHNLLEGPETDATIAAFQAHRHAPAWALPAVRDHALVIK
GVSDEFVAESTLLERDDILLHNELNATLALGHMLSIADSGNDRPEMRTYYVSRAGFYLTS
LPFYGHGRIPEQYYEQVSSRWFLGHALRLNPARGVRWLHGRDPSMPSGQRVTASIPLDDD
GRWFGVLAMDFPISAMRDFLKNALSNDEAGGEIMLFDGQLSPITTTSSDIDSTLHFTPQE
KATLARQMELANHGDMRMDTRFITWAKLDYFDGVLVKVTTFSQSAEGKFGKVAMVLGLLW
LLFTAMLFISWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARLAAKECEAQ
QQPFSVIQLDLDHFKSINDRFGHQAGDKVLTWAAGMLSRTLRAEDIAGRVGGEEFCIILP
GTPPEGARLVAERIRQRINSQEILVRPDTTIRISVSVGVSEAMRDGDYDFEHLQSIADHR
LYQAKQRGRNQVCDEG
>A0A1W1HRD0|diguanylate cyclase|EC 2.7.7.65|Nitrospira sp. ND1|TrEMBL
MGILIVDDSTDDRLLIQSILANAGYEETFGAESAAAAFRLLGLDGPRQMTGRVDLILMDI
VMPATNGIEACRQIKAVERYRDIPIIMVTVKTDPVDLQLAFAAGAIDYVAKPISKIELLT
RVRCVLRLVHEIERRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAARESTPLSLIMLDIDYFKTYNDSHGHQAGDECLRQVAQLISSHVNRPGDLVARYG
GDEFVIVLPGTTVDGAAQVADTLRRKVCEAEMKHPNGDPVTISLGFACTVPSRVAAPTDL
IRAADQALYQAKQDGRNRAKQAGVLTLVHHTHKD
>A0A085A8I3|diguanylate cyclase|EC 2.7.7.65|Trabulsiella guamensis ATCC 49490|TrEMBL
MNKDIIPLQRPTFKRTLRRISVISVVITMMLVWLLLSIASVLTLKQYAQKNLELTGATMS
HSLEASLVFGDSTAATEMLNTLGKQGQFAVAEVMDRNLQRFAYWSYIPGEKQDTLNSLVS
RWLFPVPVSQPVWHNEQMVGVIHLTARASLISHFIWMSLVVLTACILLAAIVALLVTRHL
HSDVVTALQNITDVVHDVRTNRNFSRRVPEEPIEEFHHFAQDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRASFHSSIAALMNDSHAKTSSALLFLDGDNFKFINDTWGHAA
GDCVLMEVAKRLSDFGGKRHIAYRLGGDEFAMILYGVHSENEVQRICTALSQHFVRPFDL
HNGLYTPFSLSVGYALTWEHTSVESLQELADRNMYLMKNQRAKTSS
>A0A377QAF0|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MSTAWFSGHKAKAVITGQHTALHRLSRQLLWGLLLLGLLPLLLTGGLAYQRSELSLREKT
GVYLAAQADAIIDKIDRNLFERYGDVQMIALNPNVRGSAAMTAQAADAYVRAYGFYDLMV
AADMQGKIVASNTVSGDGRRIEVEKLMGRSVAETDWFKKISAGALGTGQTYYADARKDPL
LAQALGQPEVSLLFAAPVFNAQGKIVRVWANFASYERVVDAIVSSTKAHLNQSGYKQVHL
QVVDKQGRVLSDSAGEPFGSLALAKRSPAVQALISGNNGVLTEINHGDEELVAFSSSKGA
LGFAAYGWGVVVRQDTGEAFASVRELGRIVLFSLLIAIPLVIWLAVMMSGRFQRITLQRE
QALIRDAALQDFTSEVHRALELVENDSDAAGIVSEAIEQGLPQRSTALLMSDSSTAHLSV
MSRSENYSAESGCGVKSPVQCLAFRRGQVQKFEDASALDVCRYMRGRAGGECSAVCIPLT
SIGQAVGIMHIVGPARHLPDEDEMLRATAIAAHAGMRLGVLRVMSESQLQARTDPLTGLL
NRRSLENQAARVLVMPEPACIAFADIDHFKRLNDSYGHDTGDRALRLFARVMKEALRPGD
LVGRFGGEEFVVVFPNTDEAGGLCGLERIRAALEGRIAVAGLPVFTASFGLASAFGPVDF
SELVHIADMALLEAKRTGRNKVCIAGKGSDLPIHAVDLSVASRLKPEIALPNKPDGAILQ
EARVKSE
>V5C1N8|diguanylate cyclase|EC 2.7.7.65|Methyloglobulus morosus KoM1|TrEMBL
MTEKKSILPTYNVSPERNSAYIRQMLPLMLKHNVPVDPMNYAVWYHYVAGINGELTNAID
SLIEDQKPFDTDVTLNLYKKYICNASIDEFEKINNNLLKLINQTSVSINTASEKASVIGD
NFNHTLKVLETNDDGSNIKSVLIEIILQTTQLAEASKDLKSQLDETQKEMEELRKELSVV
RETANTDKLTGLLNRWAFDKALEELIHTAIPNQACLAILDIDNFKRINDGFGHLVGDKVI
KHIAAILKRHAAPHHQVARFGGEELAIIMPDTTLTEAFDFIEQIRLVLDVSRLTYKRNTE
TIGKVTVSAGIASFQAEDEITHLLTRADKALYRAKETGRNKVVTENALLQ
>A0A5H8E442|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hvittingfoss|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREACQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q8EEZ3|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MDEGMQIVGAVSGLSTPFNQNVSLECYNGILSMLLNGAPLADILHALVLKIEDQRLGTHA
SVLLLSEDGKRVLTGAAPHLPDSYNQVIHGVEIGPEVGSCGTAAYTGQRVIVEDIEHHPY
WALYKSFALVHGLRACWSEPIKDTQGKVLGTFAMYYKEIKSPTVADLTLIAEAARLASLA
IERSRSLEFQRLAVKIFDRLPLALVITNASHSVLYANDAFKLMVCLQPDDILAFNPEQFF
SPSEPHEIASLFNHLSEGKMWQGELVGLRNNGETFYLDLTVTVFRESHSADLGFAWLFSD
VSERKKAAQLIKYQANNDSLTGLANRNALFRQIQELINADSLTPGFSFMLMDLDNFKQVN
DTYGHDKGDVLLVQMVEQVKICLDPQAVFARLGGDEFAILLPGVVTQRELSQLADKINKQ
VYRRYELSHDKGVYSSVSIGIARFPEDALDLEQLLNCADQAMYISKANGRNRYHFFTEQM
QQNAERIANLHTLLKQALEQNAFELYFQPIVDATTGLIVRAEVLLRWQHEGQFISPDEFI
PIAENSGLIVSIGRCVRQAVMQTIVEMQALGWPMSLAINVSTFEFWSHELQDEFCDSFTD
IIEGLGVEDFPYELITLEITESLLMKKHAHLIQVLNELRARGIKISLDDFGTGYSSLSYL
ANFPIDQIKIDKSFIDRLAEGERHLALIEAIVRLSHALNLRVTAEGVETQEQLQVMMDNH
IQEIQGYLFYKPIPKAVFFELLAKQAVISPHS
>Q8E963|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MEFDPQALLLIKFICLLTGTAAIAWGLIAQPLKIATLASMRFSLANICVLLGITLNTQRT
ESDSYFYWFCADIAILLGFIMLRWGTQYLFRLQHSARFDLTTLAITAVLMLMVPPNFHSE
PVLAMLFSANAALSFVMLTRDNYYAIRRETGNKVAIAMVMPLIAMVIIFAIRFFIALFAP
HETQTFIAIHTVEAIPMLWFYVFLALLINIVMIGNAMTRLVSKIRVLAEKDQLTGLWNRR
AMQKRLSHIHQRWQKKAEPYSVILLDLDHFKHINDHYGHDVGDIALLSAARLFSSALREH
DVLCRHGGEEFLVLLPATSSQAARVVADKLHRILRENPINWQDKKVQLCASVGYATIYQG
CQPDKLLIEADHAMYRAKSEGRDRICQALTTQ
>Q8EGU1|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MDKSIFLPLVQNAALLLALVFLYDAIPKKHQRQYFLLWRLGIGVLIGGIGVAIMSTPWMY
EPGIIFDTRSVLLCVSGLFFGGLPTAIAVVITALYRLSIGGVAMWVGVGVIITSGLIGVI
WRHYRKAHLASISGTEVISFAFLVHLVMLSWFFLLPGQHVVPVLSKITLPILLIYPLATW
LLSRLLSRRFELERDEQIRLQDDFLFRSQFNIGNIGIAITGIDQKWIKVNPRLCQMLKYS
EDELLHMTWKQLTHPDDLDADVAKFEQMLAGNIDNYELDKRFIAKNGSLVYTHMTVACKR
TNHQVLLVISGYLDVTAQTLADREVLASREQLELVLSSSDLGVWDWDIRNDHIERNTRSA
DILGCDIDMLNANSRQWMDSIVAEDRPQVLQSIEAHIRGETPQHKMEYRLKTLNRDIRWI
LDTGKVVSRDANNNALRMCGTYTDITEAKLIEESLKLSALVYDNSSEAMSVLDENGVIIT
VNAAFTDITGYSESEIRGQHIRMMYCDLNGHEFYQQMNDDIRNKGEWQGEMRQRRRNNEE
YVIWLTINTIKDKDGLPHRRVALFSDITDKKQSEHLIWKQANYDTLTGLPNRRMLLEYLS
AEIKTADRNRNHFALMFLDLDYFKEVNDTLGHAMGDLLLIETASRLKSCVRDADVVARLG
GDEFTVVLSSMADHKGIERVAEHILRRIAEPYYLGEETTHISASIGITLYPDDSPSIEGL
LKHADQAMYAAKDQGRNRFNYFTPSMQEYAKYRMRLIHDLRQAVLNKEFELHYQPIVTMA
TGEVLKAEALLRWFHPERGSVSPAEFIPVAEDTGLIVEIGNWVFEQAARQSAQWRKTLGV
EIQISVNKSPIQFRDEGALLHNWLELLQQLDVTGAGVCVEITEGLLLDASMGVTEKLLAY
RDAGVQVSLDDFGTGYSSLAYLKKFDIDYLKIDQSFTRNIDTDENDHTLCEAIIVMAHKL
GMKVIAEGVETEAQRQVLLRAGCDYGQGYLFSKPVSASEFASKYLLT
>A0A0T9L7D5|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MPYSSRINTRRSGLSFAKMTYLPRVFGLGIGMFCVGSVLYTQNSPLWLWFMLALNGLVWP
HISYLLALRSEQPFEQEIINMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFKPETSPFQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRKHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAIIILAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREILLRIQEKLADLVF
IQAPTLQLRVSAGIADYRHDMVNYQQWLKAADSALYLAKDNGRNRIELAS
>A0A8B3UV18|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MEKRKKPTLERATWPTRQAMVMHGLAMNLPWLAFVNISFAVMILLRHVLLKASDPLYPHS
PQLTRIVDASMLGIVILSAALILMAWRRIADISVVLFICSAIWSVSCFWFITQLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPIASWIRNDGLNLHFVVIWSVFTLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKPFSL
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPEDVVSRYGGEEFLVILFNCPEN
IAEKVALRIQDGLRAEAIPHGASTVSDHVTVSMGIAGMAGGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A7D6YE99|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MMNDEFYDNHENIREAWYQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQL
LSGVWWLLLVGWVFVWPHLAWQLAFRSTCPHGGEIVNLKIDAIIAGVWMGLIGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRAGDYIGRFGGDEFAVIMSGTPAEN
AIAAMARVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A381AAK7|diguanylate cyclase|EC 2.7.7.65|Brachyspira pilosicoli|TrEMBL
MIKEINKIIKTLNNIPEPFSVDGIIKTFEKSSKKIIKNFALYFYKDNNSNLWYSTSKNII
KENNKYKLKARNYEFGYLIIESSVEKEYLEIIVNHLSIILYSEKLSFLANRDKLTNLYNR
GYLLKYLENKKDEIYSIIIIDLDKFKHYNDSYGHNVGDHVLKIASRVMRETIKNIKYSSL
LARYGGEEFIIVIDTKTKKELFNIMEIIRKTIYETDFSTDEYSLKATASFGGAIKTDNDT
INSLIEKADKALYEAKETGRNKSIINNHTETYKL
>A0A2S6R575|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha10_Bin1|TrEMBL
MAHSTNTVEDFPEPGSELAISVGAIADKLLQTIRDKGNRTDADQRGLLERALAVATEAEQ
RLAEQSRRIALLEMLTLTDEVTGLMNRRGFDRELNRALAAARRYGDTGVLTLIDLDDFKT
INDVYGHLAGDRVLRTIGQLLQLQIRENDSVSRIGGDEFAILLAKCSVESGTARAEEIEN
VLNEHFVNFGGAAIPVRGSVGIAKFDRNDDSESLINQADQAMYKKKHKNSRERTRNGQSL
LLGPHFGESD
>A0A3B9P1C5|diguanylate cyclase|EC 2.7.7.65|Gallionellaceae bacterium|TrEMBL
MLKQNKSEEFAREWQRLHEQVPASTRQLVNDTVEHHAAALASLFYDHMLADKDAKPFINN
EVVNLRLHASMQGWLRELFSVKQPEAAEIYKHQCHVGVVHARIQIPIGLVLRGSRLLKQG
ITEHLVESELDRAGLVQATRFISEVMELSMSAMTDSYIVNVGKSVRNDESYRMFALGQNM
LAERERQRAALSEWAQDILMHLLGDGGSDVPEMRHSEFGMWLQHKASIIFHDAPELERIR
GCVERLEHVLLPELIGKRSKGGDVREAMKQVEADIGEVKFLLTGLFDRFIEXFKKINDSY
GHDAGDLVLQQAADLVTASVRVGDFIFRYGGEELLVVLVEIDKEKALVVAETIRERFAAE
PLRVGDSRTAQVTVSIGVAAYNGHPDFETIVKDADDALYRAKQSGRNRCEAA
>A0A380AHN7|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MSREPEAILDSVVQLTEQRQLDSLAESLVSTVSQMLSIDEVCILDVDKLTKRKGGLDGQR
NVNGATLAVSVKLCIEQQREICFSNGLHQELAVPIIINDKLTKVLLVSAPLLTEQDMVLL
RGFAKVYENYFHIVVESETDSLTNLLNRKAFLPQLYSSVEIACELKQEQASMDAEEELKL
WICIFDIDYFKKINDTFGHLYGDEVLLQVSALMKQVFNPQDLMFRFGGDEFVILPAPRTR
SALLKLCQEFTHRLAKLQQERLGGIRISMGIVGIDPRVEPGTLLNQADNALYFVKGNGRN
QVAFYGQLLEEGKLQGPQIEDDIELF
>A0A238IW48|diguanylate cyclase|EC 2.7.7.65|Boseongicola aestuarii|TrEMBL
MLILDWITLSVVSGVGFLAISLVPIVQLLRITRSRQLRRAWLWLAIMVVGFIVGYLLLAE
LLPRDTDVVLINLICVILVMGGVFVMSVAVLALRTADDVARLVHLEREVVIDPLTAVYNR
RYFSEQFEREFELALRTGVSLSLLVIDLDHFKKVNDTHGHAIGDRVLAVVAAILSERVRS
SDIVVRYGGEEFVILARATSPEVAARLGERVLSAVRAMKVSCPGNCTLSITASVGVASQE
PYDTRETLFDRADAALFEAKRSGRDRVVVGGGVCDDRSMRERRA
>A0A0Q0I1F6|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MMRFLLVCVLMLCAMPSWASITDYVVKQWNIKDGLPSQSLKSVVQDQQGYMWVGTQFGLS
RFDGTTFTNYNTQNSPFLPSNGINKLLIDSNGYLWVGTKSGLVVINPQTLAAQEFNIKGP
VRDILEDAKGSIWIAANGLYYVDRNQVDLRDKANALVPIVNATVITQIVGSVSQMALSPE
GIWLVNDRHLLRLTKSASDFSKLRLELTAKVSLPERLAQTIVHDLSFLNGNLYLASELGA
YFLDLDDELRPFPLPNANNSAVYKFMSDTNGGLWVSTYGRLLFRAKSGEWQWVEPSQLDQ
SIWFADIYHDSQNNIWLASFSEGLWLAHEGRIERHSALSQMTEAVMAISQAPDGNLWVAN
KSGIGYFDLNKNFVNKIPSAQFGRATVHDLQFDGSRLYIATGRGLFFYEQDKLYSFPGRA
LRDNPVFAISPSSKGGFWIGTGRGLYRLSYGGLTPFAYNAFLGSKFITYVLDKANFGVIG
TSKGAYYFTDRGIEKIGDQTSLESAYITSVLHIDGVGILIGSLNDGLFYRSLQGHWRQLD
AANGLPYGSIFSLEYDETYKRVWVSTMKGVYRMPVAQFKGEVSSLKVEEVISSFDRQLDG
KASQCCNGLGHDAVAMTDYSIWYPSLQGIVEIPKNTELFGLNVLKPKVETLTTPLRALTT
AALGEKPLLDTDERDITLKYTAIDYYAPNSIEFRYKLSGLDSDWRYANSRREAIYTNLPA
GAFLFELEAKRQGEDWDRAQTAEYAFIVPQRFDETIYFRLLIVSGFILLFYFIFWVFRAQ
ERRKQEVLEALVTERTLELRQANDKLGQVNSQLKLVSHSDELTGLRSRRFLFDQLPKDIE
HFQRNAQSLQAQGKSLVLLIINFDNFSRINDAYGPIAGDSCLQQMAALLNSRTQGSDYVA
RWSGDEFLLLLRDFKCNMIDSYASDLCQAIALNSFQLPNGKTTNITASLGWSFYPLPLLG
GQVISWETSINLADIALHQVKKRGGDGVANITFDKQLDAFEFEQNSNVDQQLGILQSNGL
ADIKVWMR
>A0A735KYR1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 16:z4,z32:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A2L2JGR4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SGAir0187|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAAAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGLMIGEIRLTARDSLISHFIWTSFAVLTGCILFAAVVALIITQSL
HRGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICSALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTIS
>A0A8F9HKW2|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MARHSRKLSFTMPILIGFAGILLSFLLIAVFVTTTQRQNFLEDYHHVNRNFTHNLAVNYT
ESLLRGNDYILARATKFFANNDKLNQAINIDPQSGLQELMQLQELMPTVSSISLADTQGH
YLRAPEVLENDNSRAFDPKSRPWFIKQAEASTFSHYTSPYLDFFTQHPTITLYKPVISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDTGALFKPYVRDDLMD
KMTSAEGQLYDEKKGIWYYYYSFTNPDWFVIYRVDNTTLVDLTRYETDIVLWGFALAAIV
IILFGLYLRHASHTVLMNIINAIKTGDVNRAPRLEAMLSKAIESNKQRELIYVRQATIDS
LTGCKNRRAFDSDTAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQI
LQPQNISLYRYGGEEFAVIFTGEHIANAPAILESWRLNIAQRTWREEGLMVTFSAGLGEW
NMEPLEQLVVSVDEALYKAKQQGKNRIVRA
>A0A1C3YQ15|diguanylate cyclase|EC 2.7.7.65|Kosakonia oryzendophytica|TrEMBL
MRQENVVKEKRRLGNLKKYFYPARVVNLCFVIVVVCSTILTWREVIVLEGAYVASQRSML
ENVSNALDRHMQVGVDRLLFFRNGMQSALQTPLTLDVMRNVQNGFEQQRRLPQWDIKLDN
RRTLPLYGVSEFFVDQSELLNRDHPLLHNELTAAMELGYLFRLSANGGMLPRRAYYVSRA
GFFVATYPLENNQQIIPTYYHLLMRPWFTGQSEHENRSRTVRWFTDQADGGKSDKGFVIA
SVPLDYEDYWFGVLAMSFPVEAIAQQLKDAQEGQNKGEYQLYNSQFQLLTLAPGVSHTEP
VFNAEQHARLAQGMAQDTRGGLRFGTRYVSWQKLRHFDGFMLRIQTLREGLQGDFGSISV
ALALLWVLFTAMLLFAWAVIRRMVNNMYSMQNTLQWQAWYDPLTRLCNRGALFERAKILT
EEARVSQQPFAVIQIDLDHFKNVNDRYGHQAGDLVLSHAAGLISSTISSEDVAGRVGGEE
FCVLLPGSTLEQAVRVAERIRARIRGKEILVHKHTTIRISASLGVSGALESGSYDFETLQ
SIADSRLYRAKNSGRNQVCSEDAAPKPKK
>G2ZW36|diguanylate cyclase|EC 2.7.7.65|blood disease bacterium R229|TrEMBL
MGLGGLILLLALGSVLLTMANAMYSSYRTQRDLLIRNALEANRVYAAKLAESTDSEELAY
GAGLLATHMEDPARLAEEAERLRQQTGSLNSVVIVRRDGAVIAASPASLQLKSMRSDWGR
RLLDSRIPEISKPFRAPTGRLLIFLSHPVIDGQGHLLGYVGGTIYLNEKNLLHTIFVHHY
YRDGSYIYVVDRDGTVIYHPNSGYVGDMSRANPAVAEVMTGGAGAQRIKSLHGVDMLAGY
APVASTGWGIVVQKPTEVTLRDLNGLMLVTLSHSIPFFALSIVFIWWFARSISRPLVELA
SQARLVATPERLERIKTVSSWYIEAHRLKRALLRGTRLTSSRLARLNHEALTDPLTGLYN
RRGVANALRLHAGAGQPQPFSAVTLDVDHFKRINDRNGHDVGDQVLKHIAALIREQARHG
DITGRIGGEEFIILLPGATPDGAFKTAERLRRAVEARPNPTGQVVTVSLGVAHYPLSSGE
VDAVLKLSDLALYQAKRNGRNRTVLYQAEIAEGPGEMEQAPRARAEGG
>A0A099S182|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. HMP271|TrEMBL
MQQISNHQLVAEWLRLLDGYPAEAAVALQAVANEKSQELAEHFYSQMLAEPHSASFLSHE
QVKTRLGKSMQKWIITVCSSTAHSDLDAVVDLQRKVGDIHARIEIPVSLVLRGSRLLKGR
LRQLLEQRELEEPVRRKAARMGADLIDLAVEIICFAYSQSHDRNSRAEEAYRLFSVSQNI
GVEKERQRAALLDWENQLMFDLAIGNLTGALPQLAGSEFGLWFRHKASHAFQGSPESASI
LDYITRIDDELKAIATLGDPTGRLAKLHHIREQTRSIKFLLDSLFEQANDLEAGRDVLTR
LLNRKFLPVVMAKEVLYARQSNNTFGVLAIDVDHFKRINDTHGHDGGDQILQQVGALLAS
NTRGGDYAFRLGGEEFLLVLVDIDPNQALAAAEKLRERIAREHFRLSSGEVLQVTVSIGM
AVHDGHPDYERLLQQADQALYQAKHGGRNRCVLYAG
>G2ZX68|diguanylate cyclase|EC 2.7.7.65|blood disease bacterium R229|TrEMBL
MPSPAIVADGAEAALEAARAALRSPAAADVPAMVLLVDDQAIVAEAVRQALAAEDGVDFH
YCARSEEAVATAVQTRPTVILQDLVMPGTDGLTLVREYRANPALRDVPIIVLSTKEEPVI
KSAAFAAGANDYLVKLPDRIELLARIRYHSRSYVSLLQRDEAYRALRQSQQQLLEANLEL
RRLTNSDGLTGLSNRRYLDEYLSAEWRRSEREQMPLSFLMIDVDNFKLYNDTYGHVAGDE
VLKRIAVTVDGCLGRPGGLAARFGGEEFAVVLPGIGLDVLAQLAEKIRLAIEALRVPHAQ
SSTGAHLTVSVGGAVMVPAAGAAMTGLVEAADLALYRAKHAGKNRAVVGAGAGAGRGG
>A0A7U7EQ21|diguanylate cyclase|EC 2.7.7.65|Pseudomonas carbonaria|TrEMBL
MKQPPKVPSILDLYPEETRESAALLKQAVPLMVRHDIPPNPVHYALWYTYSQGSSPELNR
RLDKVVQDFETFPPDTALKLFREYVIHGELEEARAGQRQAVELVESIEGDVSSNLNHNQS
YQNSLSQGLAALHEPIIDDLPNVLNDLQQSTQEMQKEQERFLQRLRSAQDEILNLRSQLQ
RAHLAANLDSLTQVFNRHAFTRLLEQILAAGHQGVALVILDIDHFKQFNDQYGHPLGDRV
LQHVGQLLRELLPPRAIAARYGGEEFCIILRDNDSAHSARTFAEQLRLKIQALRVKVRRT
DEVLDSISASFGLALAQDGDNLESLLTRADDALYQAKRNGRNQVYLALSA
>V7IM24|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cubana str. 76814|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7Z8ZC32|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFFGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALSLFCYCLLAALLCAAVGALGSVDVERATFIPQLADWFSEQFSTAVLILPFIL
TLTLPSALGAFRFRQLLPVIALVLSIILGVSVGGAGSITFPLPALIWCAIRYPLPLACLL
TFITGISEILLVANSLIHLSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINNLVKQ
LALRADFDFQTRVYSRSGLGEALKRQPLAEGQLLTVMVLDIDGFKRVNDSWGHECGDCVL
AQFAQQVRQLAGEQGMVARIGGEEFAVATLTSSMQESQALAEKIRQGVEAQTFVWGQNQI
RLTVSMGLESRPVGNERITELFNQLLMAADDYLVSAKKAGRNRVCTPGLA
>A0A658NR78|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. AAK_AS5|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDIMGENSHFVCRFGLWLNN
QSRYNEDDCSYVSKISATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDVLTGLPSRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACLAGLRLCRLIGQKKIPY
ADGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENERIALVDTND
GTSYPLSA
>A0A517PH84|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MNSSLIANSQTVPQQQSVHGSYHMGSSQILRELVAFSAESDELALNTQHTDDIDQVICRK
HLRKLLTALQARDAVTLGHCRRVAFLAKGIANNLGWEGIHLKRLEVAALLHDIGKIGVPD
HIIFKPGKLTSDEIELMSHYHHIGLDVLQACRTDHEVLTILSQTRFHFSGATNGYQCIGS
DVHQGARILAIADAYDSLATDQVYRTGKKHEDIMSILMGAAGTQFDGNIICALSRWEQTE
RETFHEAIQEVNRNFQPKPLTEQEIAEANLISNIFSYLFQIESLYDGFYIVNSDFQFVLF
SPGLEQLTNLRAGDMLGNSWTNHSVPVTNQDGTMLASSEHTMNRVIASGKSMTTELMLKR
PDGRLIQIEVQSVPMFGEDSRLVGVAEIFRDLSRSLKRPQEFNQLKMAASQDALTSVANR
GELETQLAIMLNQASQNQNTAPLSIIFIDADHFKNINDTYGHAVGDEVLIELARLFQHET
YSGELVGRYGGEEFVILCPETDLEHARQKAERLRLAVNNLKLENLNNNRITASFGVAQLE
SGDSLESLFHRADNALYQAKETGRNRVCSLTCEDQMSGAAPEVVAPAQSNAGKMVFESSF
SALISSDIVVYKLGGFVNDNDARLTEVNPNRAVMRLGKAGLLPFWGKTDDRRPIEVELVF
DNATRKSTSGSRNATPRVEVMIRMTPLGWIKQPEVFQKRATRVFRLLKDYFVAD
>A0A0P1FLH6|diguanylate cyclase|EC 2.7.7.65|Thalassobacter stenotrophicus|TrEMBL
MPCGFLITTKDRIIRTANQSFSESLSRPSCALEGRCLDTLLTKASQLFFDSYVVPTVFRE
GYCNEILITLEADNGLPLPKVVNVRQMDDGNLAWAFVEAENRTGLFKELEAARSAVEEQR
EELDQLCRTDALTGLANRREFDEALKRLFKEAERSHQPLALVIMDIDNFKSINDSYGHDV
GDAALQGLADILRKISRDTDFVARFGGDEFAIILPNTAVQDAEDICARFHQSISEFTCER
AMTISIGISDRTQCSPIEYQLALKRADRALYTAKQAGRNATAIWGHFSASEAVAQSKPKY
ITRTNF
>A0A654BRG3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MRRLRYVFLLLVTLGFAIGIAASLISSQRSAELTSSRIQLSAWSLAQLEHEFLKFHASLR
LFQADKLLAEQLQLDYDLLWNRLEVFLNGEENRAIRERFDAAALARSLLNQLKQDEALLF
APQLQPSEQIEQLITAYSQYQQPIRRLIVRNFTGPEAASIVDEAHAQRFLTQGLLLGLLF
CGGALLSLLFFESRRNNFLARNDALTQLPNRQSLLALQTGSVSPTAYSAVAVIEMNNFRT
VNETISHEAGDRLLERIGQTLNQLKPEGSFIARVGGDEFLMTFSERFPADLVIETLKALT
KALSFDFQSDKQLFQVNARIGVVFNSDNTHSIEKLYYCATLATREMRLSHTRGLKVFDEE
INNRYLRSQQLLSDLRRAINGTFPGLALHYQPILGLKQDVMGVEVLLRWNHPSMGYISPL
EVVELAENNQLGLPFGRWLLQRLKQDLYKLPDEMREHLYFSINVSPSQFTPRLPNSLAKW
LADAPISADQLLLEMTESISVANFNECQGILQQINALGVDIALDDFGTGYSSLSYLSSLK
VQRIKIDKSFIQGISQDLQMQRVVRSIIELCHGFNFSVICEGIEDRADDQQIRSLGSDYA
QGYFYGRPMALPGLIAWYSENRPQLLFSAQEVHDHHVRH
>A0A2H6AW56|diguanylate cyclase|EC 2.7.7.65|bacterium HR39|TrEMBL
MQDGRLARIRRTAAAALRLARRHRIPPDPACYRVLYEGCSGEDPALAGELRHLVETGTLD
EAACRELHRRLHGAREAVVEEGRRTLDHLTRELGREVEEAGRGVRRFLAELERDAARARR
EDDAGALRRLVLGTFEKIAGFTRHVVRLEQRLAESRRTIDELGRRLAEVERVARTDPLTG
LWNRRHLGEELARIAAEGRPASLLLVDLDGFKRFNDSYGHLVGDRVLRAVAEILRRHVKE
GDVVARWGGEEFAVLLPETDEERAVEVAERLRAELAGRRLRNRGTGEELGRVTLSVGVAE
RLADEEVDSWIARADAALYRAKRSGRNRVERAARTPLTERAPSPATPAPALPPEAVSF
>A0A0H3E973|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium bifidum (strain PRL2010)|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFDVATAASGSEAIEVIEKTQPDLIVLDVML
PDIDGFTVTRRIRQEGIGAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVGDLEINEDSHDVSRAGYAIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIMVTDDNGEQHKVTPLIETKRGIGYMIRE
PRVSA
>A0A5E4YTF0|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrae|TrEMBL
MRIRLWLYTACAAAGVLLICWVAADRTATSLVGDKLAQTLTSEQTVADRVADGMIHAITT
DLAMVRAIPSTLAEVDLVRNALRGQDGEAGAITRTNGFLRSVQGYFGVDMLWVINAQGIC
VAASNDNDRPSPVGQSVADKPYFKSAILGARFERYAAGWGSQTPGLYFSAPVYREGVLIG
VVMTKIGLSRLRHWVGSGESFITDGNGVVILANDPAYENRFMHGGTIGSMDLAQREALYH
QSEFQPMPIAPFRRAPGRSNAWVPQDILDRMSEFGTHEIPFVIASRDSSSNDLTIYAVED
VDTWEGLTRQHGKDVALFFLLYLGGFVIAGLAGLTYLRERSLHRKTRQSNAELRAANNQL
AFEASYDELTGSLTRRYFFHRFDQLLADAHRKDEPLSLILADLDYFKSINDTYGHAIGDQ
VLCRFVLVCSSVLRGDDLIGRIGGEEFAILLPGASERDALRVADRIRERCKRESLEGSEP
PLRFSASFGITEWQDEDSPMNMVERADMALYRAKRAGRDRCWVF
>A0A173W4N3|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MKKVALFMDGWKRYFTYAWPLGFMQKIKETRADVNLYIFNSNGNWNRDDGYSYGEYNIYN
LPELTDFDGIIISVNNIKYPEVTAELLDRIRKSGVPAISLETAFDGLHFVGIDNYDAMYD
MTRHMIEKHGAKKVWYLAGPKDNYEAQERCRAFRDCMDEYGLTVDDENVLFGDFGFNDGV
TGFEELLRAHGHTCIKHEKDGPDYGGPAEVYGEITSGSFADSAPNAETSNNDEMDDRRLE
EREIVKKILPDAIICANDNLAVGVCNRAEALGLSVPKDFKVTGFDNFDKAAYYTPRITTV
SRIREKIGAAAAEIMLNIWAGNNPDTSSYIDYNCIFTESCGCGADAMLNGRQYLKNYIMG
VVEREEIDESTLDFTHLLSKCGDYSGLYPCVQTAYSQAGCKKCVMVVDRSLVEMGGAGST
LSAAYDEDVFAVKGYPQRMQIVYKQGVADDGDDTYHSMFPLLDDEAGGNIFLFAPFHFGE
KAVGFCCVENGYYLMDKQLWSTVMSEVNVAMINLFNKWRLEQINQELTAISIKDPLTQIY
NREGMRQIAAKAFDKAAGQGRALLIMFADMDKLKYINDTYGHEYGDKAIRSAARAIAGGG
GISSIPVRYGGDEFVSISIYDETESPEERKTAILEKAREIAAQEKLPFALEFSIGYVITA
PDGDKTLEEYVREADHSMYQEKIQRRVSR
>A0A8D9L8C2|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MTNNRLNIGIFTCHIDNDYATEVCKGAEYAAKELDCNLIVFPGMFLNASFYDPANQLYDY
QYNSIFYYAHPECLDALIISVGAISSLLSEKDMNSFLSHFDGIPILTLEEKLPGYPCIRT
DNSRGMRDAIEHLIKEHKRKHICFVAGKDDNTDSNLRLKIYREVLSENGLSVEDRMIIHG
DFAEYCQEETAQLLDVNPDADAIVFANDHMAIGGYAELKARGIRIGETMSVIGFDDSPSS
VNMDPPLTTVNINSCELGFRAVYAAVRLAQTGNMKSEALDSRLINRVSCCCHLCTESDLM
KDGRHLLDLDIPDIIDILDGRLFGEIADSFYASKVMSAYNRILIDIVSVIKSDIDTEYPQ
NKIIDELKCILESDLTDFYSVQKTAYMFRELASIFSSCKLSAAKSLQFNRLNTTITNTIS
LFISNQLYNTIYENKMMGWSSIYITRDTLTYGEDLGKTYTSILHKLQGLNYEGAYIYTYD
DPVRITDTGSWIVPKSVFLQAFFNPNNCQVLFGESRRVPSIEIFDNEYTYYDKRFTSVIV
PIFTNEDQHGVFICNTDVAHFSSIYSTSLQLGAALKYMSLLREQNITQEQLRMSLNEIHE
KNELLNHLSTSDELTGIYNRRGFMERVEYYINIPSNCGMKAILLFADMDSLKVVNDKFGH
KDGDFALKNIANILSQSFGPHDVIGRIGGDEFVCFAFIDDSDYVTEVQRKIKDFSAELNA
TCGKPYFIEMSVGVTEFVCDGEQTIEDLLSQADTALYSNKRYKRMSILK
>A0A679J902|diguanylate cyclase|EC 2.7.7.65|Variovorax paradoxus|TrEMBL
MVATILVGMLCAHLLCFSAMFFLIGRRLHGSKMGMDLFATGNLMLGLAYALQSAEGGPAW
SLMSVIGHTLTLAAPVAYWLGAMRFFGRSVPFWRPLLAVAGAYIAVQVLVQWGFGSVARY
ALLSAMMALLFLAMTATVIYGVLTFARDLYGEMIFFAVLISGICILNAIKFVNIVGTGLD
ALRMSGGFQIVFYVYMSFLATVLPPAIVWLVLRRLTDELRNVAARDPLTKLLNRRGLTEA
LQRHFSFRKAEPAFLVMVDVDHFKRINDNHGHQAGDQALCRVADVLRTHVRGSDLTVRTG
GEEFAVICMNADAREVAHLAERLRSAIENTAIFVDGVDGPLHCTATIGISRAFTGEDALE
SAMKEADAALYQGKGAGRNRVEMWEAVRRDVPASMSDPQASW
>A0A841KTG2|diguanylate cyclase|EC 2.7.7.65|Anaerosolibacter carboniphilus|TrEMBL
MKEDNFKLNLFLCLILVGISYGFIFHSVVMPWFGGQLLHCIFMGVIFGIVNYLITSKFYK
NYRQLKVTNLDLSEKLRMDKLTGLLNRRAFDADISEMQGNTGFSLIFIDIDNFRNFNNLF
GHQVGDKILQRVSDVIRSSIRCQDRVYRYGGEEIVVLLNQCDKVNASNIAEKIRFNVSGL
DNSPYPEITVSLGVSSHGEDGHYLDDVLIAGDKALLKAKSRGKNCVVADVC
>A0A7Z2BTH4|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. SO10|TrEMBL
MTLEILTSQERPQRTWLNALLIGGLTFLLTLFCLELIVVSGRISPLWYSTALMTVIVFRA
HSKHVPLLLLACVLGTALANLIIIGPALSNIKFAILNMVQAILGGVMLRALLDRRAPLNS
LLDWVRFALCAGLIAPLLGGVVALWMLHVGSNASLPFFSTWVISEVIGVLAFGPVLLLWP
NKPLRQILTPGRQLETGLTLLVTLLASYLSLRFLPWPFTFIVVILFWCSVRLPKFEAFLL
FFLNASFISILLAFNWVNLAQNGMLLGQVSTWLPFLLVLLPSHVMALVMDAFQREKHHIS
ESETRFRNAMEYSAIGMALVSPNGGWQQVNHSLCQTLGFPADELKKLTFQQITHPDDLNN
DLQQLERLVAGEIMTYTMEKRYFRKDGEIVWARLTVSMVRDAAQQPHYFIAQIIDISELK
QSEQINRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYELFGLSPHQTPTYDLWMHL
LDPAERETATLAVQQAIERRSAFQLEYRINLPEGPRYVRSEANRILSQDGQIERMLGICQ
DITPLRALNEALFQEKERMAITLDSIGEAVISTDDEMRVTFMNPVAETLSGWPQEKAAGV
PITELLNITRGASGPRVDNLLLCQLPDEKISPELDEELVLHTPDGTRVEIHYSITPLKTL
TGASIGAVMVIQDVSESRKVMKRLSYSASHDMLTRLPNRHSFEQRLKQLVNDAAANHTHH
VLVFIDLDKFKAVNDTAGHAAGDALLRELAELMPHHLRSSDMLARLGGDEFGVLMPNCEV
DQVRDVVQRIVTAVSEYRFMWQEQTYHVGASAGITQIDQRNCISNVVMSQADVACYSAKH
AGRGQYHVHQEVQM
>A0A5E4SFS5|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MVSASPQGRPAQADGSPQRRTAASSFGVDSAVAGKGKRFVRRIYRLRTIGLAIGFFCVAG
VFYRHDPAIASWLWALLIFNGFVWPHVACLLALSRPVPYRAERWNLLTDSAFGGFWVAAM
HFNLLPSVVVLAMMSMDNISAGGVRLFWQGVLANVAGVLVGIALLGFAWAPASDTFNVIT
CLPMIILYPIALGKVTYDLAQKLANRSREMEYLSQHDGLTGLLNRRAWEQRLADIYTHCA
ATGQPACLVLMDLDHFKRINDTLGHAAGDTALRRFSGLLRQRLRDIDAVGRYGGEEFGAV
LVNTGGIAGQDLMHHLLADLRARVAQAEAQLQLQMPDTDGQSLSLAECTVSIGLVPFSVS
FDSPQAWLQQADRALYRAKRDGRDGMVVFEASSPDR
>A0A329H6T1|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RIT 418|TrEMBL
MNKDFTSTPRPTFKRTLRRISMISVVITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSMAANETLSTLGKQGQFAVAEVLNAHNKRFAYWSWNPQDNTDTLGTLVS
RWLFPVPVSQPIMHNGNAIGEIRLTARDSLISHFIWLSFAVLTGCILLASAVALTLTRSL
HNGVAAALQNITDVVHDVRTNRNFSRRVTEGQIEEFHHFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMENSTAKTHSALLFLDGDNFKYINDTWGHAA
GDSVLIEVASRMVEFGNKRHQSYRLGGDEFAMVLHGVHSEREVQHICAALSQQFIRPFDL
HNGHTATMSLSIGFALAWENASLEALLEQADRNMYQVKNLRSKQ
>A0A7W5UMA1|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK612|TrEMBL
MPPQLIYRGALRRLGIAMEVETHLISLIRVLGQVAIIVYAYSWVIRIVERGALKSVAVGL
LFGLVGILSMGDPIQWMPGVIQDGRSILLVLTPIYGGLLGTIVAAAMMALFRYMVGGMGA
VVGVAGIVIVAIAGYVLTLLPRQWTGTGWRRSALFGLATCSSIVVVFLFPWTVARALLIS
ATLPVTIVNILGVMLLSDLLQREQYRIGIQRALENEASLDPLTRLPNRRVLQREGDRCSK
EAGMRRIPFSIIMLDIDHFKKINDSWGHSFGDTVLARLADVIRQTVRKTDIAARYGGEEI
VVLLPNTDTRAAAAVAEKIRKDIEDTTLMFEQEAVHVTVSIGIACSLEPTTDFKHVLEAA
DKALYRAKAGGRNRVELAEAA
>A0A212KMT7|diguanylate cyclase|EC 2.7.7.65|uncultured Alphaproteobacteria bacterium|TrEMBL
MDADAILIKDLETPGGDATASGAHGAPHLGAARLLTWRVAVGSAALISLSAVALASVLLA
ADEAPLAFLARFDEATLRHAGLAAIAALALLPLAFLAAVWLVALRERRQAEALALLRDNR
EALRLSRDQMRRVFASLPVAYVLAHKDGTLVRANPQAVALFGLQGRDLSEVNVFDFTEDE
DFSEELRGYLADAGRIENFEITMRRPDGKTFWVLYSAAQVEMDGETLLFAAFSDITERKR
VEQALQKNETALRAIIDASPIPAVLSNQASGALVYVNQAAAKFFGRGAPELIGRSAANLW
ESAEQYGGLLTELGIRGHIEDREARMIRADGRPCWVQTSTTVLRLQDDTLIYAAFTDITE
RKRKESELHRLATTDPLTGALNRRAFTERAVTEGERARRGAYPVSLVICDLDHFKAINDT
YGHARGDVVLKRFTAVVQELIRPSDALGRIGGEEFAVLLPGSDADAAARVAERVRARFSA
EPIAGGDPLVATASFGVAGWRPPFNLDAALQAADAALYAAKAAGRDCVRVAGAETAKIVP
IASASRNGRGRSGP
>H8FVX9|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MSQGTDSTQLLIIEDNPGDRRLIEIALADAMPDWSVSSCSCLAQALTLAPFNRFDCLLSD
LGLPDAQGIESVLALRAHAPSKALVVLTGLDDERVAQEAIRAGAQDYIVKSDAGLTMLPR
VIRHAIERQQSQSALEASHRTSQALLDASHDVAMLLDSEGRILTLNAVAESYLGRSLDQL
IGVSLFDLLPDSLVAHRLGYLAEALHSCETVEFEDTDGLHWFANRLRAVAGETPGQHRCA
LFSHDSTAERAAAAKLAEAKDEADVANRAKTEFMGRMSRDIRTPLNDVIGFAEMIATEML
GPLDQPGYRDYAETIYRSGSQILKLIDRITDVSMLETALLKDQASYRDLVELSPDLICVC
VDGIIRRINAAGLGMLRAPAPSSCEGRRFVEFVHVDYRAMFESGLDVLCEEGHPMPVKVV
TFAGRVRDVELSAVPLRREGHTAVLLVGRDTTEVTAAMRAVAAREHRIRAIMDTVMDGIV
TIDEEGTLLNANLSVERIFGYSLTEVVGSHVSLLLPELDSSRLTVAIHDYLSRSFGAVVG
AEAVGRRKDGTAFPVHMSVSELRVENRRLFTGTLRDLSENKQLAQRVDYLANHDPLTDLP
NRTGLAERLGVAVVRARDSSRMVAVVTVDLDGFTTINDSLGHESGNLVLRETARRLAQNT
GPDGTAARLAGDEFAVVLPQLRDAAEVSAGVERLREALNRPYIIQGTELTIGADIGVSVY
PRDGDDAFDLLRNAEVALHSVKRLDDSRLGFFDAAMSFAVTERLTLERSIKAALKAEQFE
LFFQPQVRLIDFRLVGAEALIRWRHPELGIITPDKFIPVAEETGLIVPMGTWVLQSACRQ
LRHWDDLGLTGLRMGVNISGRQFREQDLADLVAEAIAETGVNPAQLDLELTESMLMADGE
ATLKILRALARLGVTLSIDDFGTGYSSLAYLKRFPVNTVKIDRTFVSDLDQDKDGRAIAN
AIISLAHSLGMKTIAEGVETEAQAAMLASHGCNEIQGYLIERPLPAAEFTAFVARYGANG
GRGLVGSRLSLVQEGG
>A0A7S7ADI3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFAFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSQLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSNQQQKLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A5Q5E5Z8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. CRENT-193|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPSLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMHDALETPLAFGALHDAVKRFAHLRTSPTWQIAVDK
RRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYHHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSESPAVDVN
HFDARELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVILRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFDQAKILA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRDKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHLKK
>L0RF82|diguanylate cyclase|EC 2.7.7.65|Maridesulfovibrio hydrothermalis AM13 = DSM 14728|TrEMBL
MNPTTEKSGKYSASEVDAEVKDIRTRFFDSVSHLAIIKDPSLRYVCVNEPFLKVLGLDSP
SDIIGKNNSEILKGLTTEEHINQLLIADHKASNLPTGKHVEAEIVINTPEKDCTFSSKKF
PIRDDSGNLLGIGILTCDVSEKKTKEKKFARDHKKLTRKIETQADTLRAANKNLQFMEHV
FQNTLDGIIITDNKGQALQINPAFTEITGYTLDEIRGKNPRILKSDYHDENFYKEMWNTL
AENGTWEGELWNRHKSGEIYPQRLSISAIHNSEGIVTHYVGVNNDISELKRKEEKIHFYA
YHDVLTNLPNRKLFSDRLRLELEKAGREGYQVALLYMDIDDFKKVNDSLGYTIGDELLKQ
ISKRIKTLLDDSDIFARLGSDEFAVAQVDIRNINNVITLAQKINGLTIKPFMIEGHEIFI
NSSMGISIFPDDTDCPEQLILHADTAMHQIKGTHLEHFRFYTSQMKIEAQHKIDMESAIR
KGLMKGEFIPFYQAKVSCKTGGVVGMEALARWVKADGKIISPVDFIPLAEELNLIHEIDT
RIITSAVRDMAEWEKAGHNELVVSANISATELEDPAFVDTIFSILEDNNVAKEKFELEVT
ESLIMKDVEKNAQILEKLCTSGINCSIDDFGTGYSSLSYLKKLPIKTLKIDRSFVNDIMT
DHNDLAIVCAIISMARRMGLKVVAEGVEDADQVELLKKEGCDIIQGYYYSKPLSKKDFLD
FINLKRDRAPMRN
>A0A8B4TMU1|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDLNAQRQQVMFAHNSS
EMQIPEGFSVPWNESLCKRALEDQCTFCNDVARRWHSCIAAQELGIATFFSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFAAARVQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQDPAAQQAYVAALRDALCGIYSLGAQRIDYAGASFGV
ITCDPQNIDVEAALRAADDAMYLDKKSRRQENFIHID
>A0A7H4M2A5|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MLSKAIESNKQRELTYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFSLALVDIDNFKT
INDTWGHLNGDIVLRNVAREGLQILQPLQISLYRYGGEEFAAIFTTGHSDDALMLLESWR
ARVALRSWREEGLTVTFSAGLGEWNMEPLEQLVVRVDEALYKAKQQGKNRIVRA
>L0RBH0|diguanylate cyclase|EC 2.7.7.65|Maridesulfovibrio hydrothermalis AM13 = DSM 14728|TrEMBL
MQKGTDNKFILAVCFACLVALLFFATQHFIKLAVKRNEVLFNDNQFDQSRIIADALTREV
ACLTSTSQVLAHSSLARFFNGTISGGEVESLFGVQIKQHDTIDGYVYFNSSGRIELEAIR
SASRKKVIEDAARSFNRGAWFEFSKSSPKPYLTFSHANSKEQLLGLVFPVRVDSRLKGIL
IQVINLKPLIKLYISPLRSGEHCAGFLISSRGVVIYDHDPEIIGKNIFQGIHNEYPEVLA
LDRRLVTEDSGQAEYLLPIKRKGKSIRKLISWNAARIGSQKYVVCIAVPAAKITGIITDF
KHIYFLTNALVLLALGLGLYTFIRRRAEQKIRENGRRLVLALEGNRDGIWDWNIKTSEVY
FSPRLKEMLGFTEEEMTASVEEWKSRVHPGDADKVSETINNHIQGNTPFYESEHRVRCKD
GSYKWILDRGKIYSLDEGGKPERMIGTRTDVTEKKRIELEIRKLSLAVESSPSAVVITDT
DGMIEYVNRSFEEITKYSSAEAIGKNPSELIKSDSQQADIYEDLWKTISSGKVWRGELVN
RTKFGENYWCRLSISPVYNDLGTIINYVGIQEDLTELKKKELALKQLATTDELTGINNRR
NFMEMADQEMRRTKRKESSMSVSILDIDHFKRVNDTYGHGFGDFVLKEMAALIQDVIREM
DIFGRIGGEEFALILPDTEAEGAFILLERLRGKIENYKFKFHGVSIIVTASFGYTVFDGS
YSESLTELMKHADRALYAAKAQGRNRVVFAREPESH
>A0A2X4T9U3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDRGATQEWEKK
>W8T9D3|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium acidaminophilum DSM 3953|TrEMBL
MFKNIFHSHSSIMFLMDIDSKTIVDANKTALEFYGYPLVGMNISDISTLERGEIERNFEY
IKLNGSMRYDEGHKIFSSDIREMNVNMSITSLGEKRYAFAILNDVTEEKHAKNMLERLSV
TDALTGIYNRLHFNRELEKEIALFKQHSAEFSMIMFDIDHFKRVNDTYGHDVGDLVLKEV
VRVVKEQVRATDVFARWGGEEFIIMAKNTPLRNAKRLAERIRSAIEKNDFEKVGHITCSF
GISVLTPEDSESSVAKRADEALYEAKQSGRNCVKVK
>A0A161Y387|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MLHDLQNLFKEEVDALNIAKKIYLESKSRGSVSIEDFQKIITSYERSLKSTMKITKISDC
QQLYLQEIQEKLQKEIEERKKIEEKLKYYAYTDYMTGVSNRRAGFTVIEQELKKCLKEHS
YFSICFIDIDKLKSVNDKYGHAEGDYLINIIVKFIKEFIKELRYVSRMGGDEFVIIFPNC
CYKEVQEIMSKISKRVEEFNEKKIRPYNISFSYGIKDIDENTMISTGDEIIKIADALMYK
NKVSKKLR
>A0A161YLI5|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MDEKLASKKELVLKMEELISNNEGPFSIVVADIDDFNILNNLHGDSIGDEVIKKLVSILK
NNLSSTDIVCRNGDEFNILLVKKGAERSFMELEEIRRYLSDNTFILGDESKAESIYFTLS
FGVASYPRDAKNVVELFRVADSALFRAKELGKNRICLSEAESMVLKSNYFTKTQLDRLSR
LSKATDRTEAFLLREALDDLFKKYSK
>A0A1V5DWT8|diguanylate cyclase|EC 2.7.7.65|Smithella sp. PtaU1.Bin162|TrEMBL
MKNLQKDNINKRIKRYESFIHSSRDVIFFIRQSDKKILEANAAAVNTYQYSHDELLAKTI
LDLQAPETQAQIISQLDNNNTSGLLLETVHIKKNGERFPVEINSQGTVIDGEIILLSIIQ
DITRRKISEQLLEESENNLRALLNAVTESFFLMNKDGIILAANETMAQRYGLAMDMLVGS
RIYDLLKPKTARQRKAQADIVIRTGKPVRFEDVRFHRNIDQVLYPVFDNNNQVVRIAVFG
IDITERRKMEKKLENIAFNDHLTGLYNRRGFINIAERQLKLSRRSRQKLLLFFADLDRMK
WINDTLGHEQGDKALIIAAKILAKTFRESDIISRIGGDEFAILAIDADEKTAEILLKRLH
KLIHHINSRKDRKYDFSISIGYAAFDPHHHDSLDELMSRADMRMYEDKKNKNINRS
>A0A143QDH0|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MTPPADRRFTKDTPDQPAIVDLVRRRIAVLITAFALPGALLILGSPAGPAPGAPRIAAVG
ILLSTVPVSVIVYRTRTAFLWFNRPSRQAALALAFTVYADVGTAAFLLLFRDQGTALFGC
ALFAVVSSFVAFFGTSVAVVFHVVATTAVILIITLRAAMDPSSDTLALAAAGVSLWLAVN
GTMTVISQTSATLHSNLRTQIGRAQTDPLTGLLNLRGLEQMVLRRVDDDVALGFLLVDLD
HFKRVNDLHGHLVGDEVLALAASRLATFVGDDGLVARRGGEEFLVVITAKNVDAAELVDR
AESARHRLHVPTDAVPITASVGASLVTPDDVAEQDVRSTIRLGMHRADIAMYRAKSAGRD
NVQFHGSRRG
>A0A6S6WMV3|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MNQFSASQVSGSFDLWQHFRLLAMRAIYFGSGVVIAGTAIYTAAQSNWAAAAALLCVALG
FALIGYLYRNELAPQWINFLVICCLGTLVSVSMKSAGILGVYWMYPILAMVFFMFDKTIF
VLVIMLIYALFAAVIYQVLPFDYAWRVAISMLVLIGVGAAFLIMMASMQRRLFSAAATDS
LTGCIKREYLSEMAQQALTKAERAKQPVSLVQIDMDSFQTVNDRYGYLFGDKVLEEAAKR
IRSVARATDTVIRSNGAEFVVIFPNTTGKDAAELATAMLDRIRHDPFAVKSLTVTVTASG
GLAEFKPGHHWGEWLGAADSALYQAKSQGRNRLKLAQ
>A0A6S6WPR5|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MQLNVPTPSEQPFVHQSQLLRAVLKIIGVFSLLIGTINIFAFERFDIAAFNFVSAIVALL
LLIYFQRSKQLLRTSWLTCAAVTFNVLMFIHLANGESYSVLWVMILPPIMFFLLGRAVGA
WLTAALFLYVIVFMALQLPSAEPRAFSISGLLNITEVCIALWFLFRFYEGSRESAYRQLE
RQSMTDKLTGLYNRIKLDAVVAEQHQLVSSGQLKRSIVVIADIDDFKSINDQLGHIQGDK
VLQHAATLLRNFTRDDGIIGRWGGEEFMLILPNYTLTQAQHYSDLLRRYIADHGTPFAQP
LTMSFGLAELGKEIPAEQTFIRADRALYRAKEAGRNCVKVAHS
>A0A5Y3V094|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANAFDRQLQFNVDRLLFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYISRS
GFYLSTLPTAFGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQTYIADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGLLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQHSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAAQEREKK
>A0A8F8GJM8|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MNKQYQRVLVTTPHPALRLVSLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIVASGLLFSWEAINFWYPTINAIEACVGALLLRKMLPWYNPLKN
LGDWIRLAIGGAAIPPLLGGVLAWLLVPSEEPLRNFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLAVTLVLCWIAITFLPWPFTCVIVLLMWSAVRLPRLEAFLVFL
ITVMMVSLMMATNPTPMTTQNTGVMLNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIDGQWLQTNKALCEFLGYSQTELQSLTFQQLTWPEDLHIDL
ESLEQLARGDINSYSLEKRYYTRNGEVVWALLTVSVVRHTDGSPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLQPDVISWDKRMFEMYEIPAHIKPTWQLWNDSII
PEDRAYAEQVIRDSLMARVPFKLEFRIRVKEGVRHIRALANRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVDMHVTFMNPVAEKMSGWTQQEAMGQPI
LSVLHITFSENGPPMENIHSGDMSRSDINQDVVLHSRTGGTFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDGLTHLANRVSFESHLKRLLQTVHDTHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNVESSRYI
AGRIIHAINDYQFMWEGRLHRIGASAGITLLDDTNYQAADVMSQADIACYASKNNGRGVV
TVYEPQQERIHSARGMMSLDEQWHMIKDNQLLMTGRSVASPRIPESSNFWLISLRLWTSQ
GDVVEEQAFRSGLMEPDLLHALDRRIFQTFFRTYASQVATKGMGVALPLSAEGLSSTTLV
SELLDLLEKSPLQGRLLHLVIPVETLQNQDINIQNGLQKLRLAGCRIVLCHVGRNMDVFN
HLIPHMADYLLLDPELVTNVHGNLMDEMMVSIIQGHAQRLGMKTIAGPSNQPLMMDTLSG
IGIDYIYGDCIAEPQPLELLLNTSYFAIN
>A0A378ZB46|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MSRGTGTSPPSRTTHTLPSLHTKRVDDRTHDAAHAAQTTHAARALWRIKSDAQPHLPSDG
RHGRIDAVADRAPAVAPTPPDLSASLTPSVPSAPSALSSTQSAPATPTVPFEPFVTSAPS
VQMPSALPESLSSALPSSPHWTSLPRRDMTAAAATSHDTVSAPDSRGAPPDDEAARLAAL
RRYDILDTPPEPAFERIVRLASHVLGAPISLVSLIDESRQWFKARQGLDTVQTPRSMAFC
AHAILSDEVLVVPDARADRRFADNPMVTGEPNIRFYAGAPLRTPEGHRLGTLCVIDRRPR
TLDDEKRALLADLSAIAVDALELRRVNRILADMAMRDGLTGVLNRRAFLMQADRLLASSR
ASQRRLSVLMLDIDHFKTVNDTWGHAIGDRVLVELTLVLRATLRKGTTIGRLGGEEFAVL
LPEADAHRAVQAAERVLAAIGSASVPGPNGPVRFTASIGVGSLAPDDADFSSVLQRADRA
LYAAKQAGRNRVAAL
>A0A4U6LV68|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
MSKQFQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGGSLNYAYTTINIIEAVAGAMLLRKLLPWYNPLQN
LNDWARLALGSAVIPPLLGGVLMWLLLPEGTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYVPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPSLLYTPKANVMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNNDL
EQLGMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPPHIKPSWQVWYECVV
PEDREHAENVIRDSLAARIPFKLEFRIAVRDGVRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDDAIGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGSSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
SGRIISAINEYQFRWEGRLHHIGASAGITLIDEKNNVATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQTHTSRELLSFDEQKHIIAHNPMLMIARGVASPRIPETFSFWLLSLRLGTED
GDVIEEHIFRTGLVDPALNHALDRRVFNEFFQHAATAIASKGLSIALPLSAAGLLSTELV
DELLAQLQRSPLPPRLLHLTIPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVE
NLKFHTVDYLLLDSEISASVHGNLMDEMWVSIIQGHAQRLDIKTIAGPVQMPLIMDALSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A1A9FDX6|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MAQGCEQGESVQREPLVAKKERITRYRNHPERIVNLCFVVVLIFSTLLTWREVVVLEDAY
ISSQRNHLESVSSDFDRQLQFSIDKLFFFRQSMGEALQTPLSFEVLRDAVANFSHLRTLP
YWQMDIDRRRTLPLKGVSDAFVERTTLLVRDDSRIKNELSAAFEVGYLLRLAARPDRLEK
RVQYVSRAGFYLSTDSLNQNQDVPSLYYQCVTRPWFTLQSERDNRARGVRWFITPAAQSP
SGERTITASIPVYFDHYWYGVLAMDFTLQAMKKLLLSASDGYEEGEYQLYDGRLNLIAST
EPTPETIGKFDKRELAQIAHAIEGDTRGGLRLASRFVSWQRLDHFDGVVLRIHTLEEGVQ
GDFGSISIALALLWALFTAMLLISWLVIRRMVSNMFTLQSSLQWQAWHDPLTRLNNRGAL
FERATALAQECHSQDKPFSVIQLDLDHFKNINDRYGHQAGDRVLSHTAGLIASALRSTDV
AGRVGGEEFCVVLPCTTAEEAAVVAERIRAQLNRKEILVKKSTTIRVSASLGVSSTQENG
NFDFEQLQSIADARLYKAKEQGRNQVVSREPDKK
>A0A0T6AI97|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium CSP1-8|TrEMBL
MQKRFLWGGVAMILVASGFAFLVARGFPRGSVVPLAAAASFALLAGVLLLLLRAFLKSSE
DVAKQRLDGYRAEITAEMEKSKEDQEQRFREIADAHNDLLTHHKLTKKMLQSYRATDVFE
TLLKGVREGFGFPGAVLGVLEEKGTIVFRSAGNGEGRPGKRIPCWEEESLLARTIWSGNP
VMIPSLDGQRHSGEDRAILGEGPAFLVPVTKKPSRKCSDVMVCGLVECPAYHLLDAKCWI
EGLPARTCTQSGEIEQKRKECARCEMFLPSAILVVRSHPGSRKISRETTGSIVALANEAG
LALKLAEMNENTRKMSITDGLTGILNHRGFYELLGRELERARRYGHSVSLLMVDVDDFKK
FNDRYGHLAGDSALKKIAELIRGSVRANDIVARYGGEEFGVILPEATPAGALMLAERIKT
DIACHRFPGHSGEVAHLTVSIGIYSTDPGDITEERMVKFADEAAYLAKNSGKNRVVVKSH
A
>A0A646MMJ3|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQEIMDCTDKNNMLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGRVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A1T5HWC2|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MVTLIKSTQLQATNFAYIELSEKTLKKQLSLLFPFAGAICAIIAFTYFVSQQAHYFTVVG
ILGMTLCYTLAALNRTLFSATILFWIFLIATTLICSTGFYFTGARHISNTIGLTIPLLSF
FALQIRTAAWYSTIFGLLYIILSVSEITNKHMQISSALQNICAYSIIFVMAFLLSRHRYD
AILQVKRTTTNDFLTGLLNREGLLPLYQNESSRCKRYRRDISMLLINIDKFREVNDRFGL
DAGDKTLMMMAKFLRETCGDNMHIARLSSQEFCIIIPDADIQAAEQFAIKIRDEISQWIL
ELTTGHQIKITVSIGITNIEYQDFSYDYIKAESALMRAKRWGYNQIATND
>A0A259UF48|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MIRYVFDIMIKKYFIVDVLDGLRYIQSLVSENQCDGFPVMEDDQIVGVLTYKDLLQAHPN
RIAADAMSDHIVYIDAHSSIWKAKEVFDTNNTDLLLVLDNNHLVGIITKSLLEVELGKHT
DLLTELPKSDFIYYNATRLIESNQEMSLAFFDVNNFGLIDKEHGHIAGDIILKELGTILK
TNMAEQTYVSRFGGDEFLVLTPYYVDKCFIFAQNLLRIISRYTFHKNISVTVSAGIVERK
KTQENSQNILRTISNLINLASLASTKAKKDKCELSIASNNTTCNFSG
>A0A259UBK9|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MKPDDETLESREINELRETVKQLQHIKEKLQRSEERYRFLTEHSVDAIWRLDDQLRFVYV
SSAAKNLLGYQPEEIVGRHLFEILVQESIDTVSQGYASRKALQEAGQRWGSSTYTVEVIH
KEGHPIWMEVTVNPIFGTGNQLIGYNGITRDISVRRRDEEVIHQYAFRDPLTNLPNRRSF
EEELGRVIDQHKDFNKSFAVMFLDVDGLKKVNDAYGHSIGDALLQVVADRVCHVMRKQDF
IARLAGDEFVAILPGIGDNSAIDLLATRLVESFYQTILIGAHKVRIGVSIGISFFPEDAD
SVNTLISYADQAMYEAKKNGGSKYVCYG
>A0A2U3QKC0|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfobium mesophilum|TrEMBL
MSLSLSRKGKDVAIALFISAAIFMVDLLTPLWYDAWVLYLVPLFFMFRSVKRPYAYSLVV
TLLIVTGLFLHPNSAILMQSAVNRITGIFGGWGVSVLLMRLKQLHVSMLQSHNELEKRLT
DLKKLQDLLSQGKKEWEETFDSINDAITIHDRDFNVIRANKTAERLLGLPFLEILGQKCY
RLYHGSDCLSEECPSCAVLKTGTPSVVEKFEPSLNKYIEIKAFPLVQDDQNIKVVHVVRD
ITDRKKMEEFLQHHAYYDSLTGLPNRLLFMEHVRLRLSYARRNRNRVAILFLDLDHFKYI
NDSLGHTVGDGLLKVVANRLKACIRESDLVARMGGDEFIVILSDITTAEDAAIVGRKIIA
SLLESFFIESHKVNTTASIGISIYPDDGEGEEDLLKNADIAMYHAKKQGRNTYEFYNIVM
NHKN
>A0A380SW70|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MMEKKSGKGLSFVRRIYLPRIIGLGIGMLSVMAGISSLPVPSWVWGLLLFNGLAWPHLAY
QIALRANVPYHAEYRNLQLDSLMGGFWTATLQFNPLPSVTILAMMAMNNFAAGGQRLFFK
GLLIQGLGMLLSIALFGPGLQLHASTLQVYACLPMLTLYPMAVGWVCYRLAMKLSEHKRR
LSALSRTDSLTGLLNHGSWKDLLQLKFQICQQQRREAVIAIIDIDHFKTINDTYGHVVGD
CVLHQLSNELKRTLREDDLAGRYGGDEFCVILPDTRLEHASQAMERLRERVGSYRNPQLP
ELRISLSIGLASCNEALPGPEAWLNEADKALYCAKKAGRNQVNFAHSDLTALKLAYPD
>A0A1C5S864|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNELEQYKERLRIALSAARICIFEVDILRQQYTFFENAETIFGVSGDDILKDVQPYSVLE
PEAYRLAVSEYFSHPDDWEVIEDAFAQILNGKPAIYDARMKAGGSGFIWCRIHVTPIIED
NKPVRMIGVIMDITDTKKKTESLEQAVNRDAFTGFYNKEYSITLIRDILEERKNLQHALV
ILDIDNFKHFNDTYGHDQGDRIIKSLSRTIKMSFRKTDILGRFGGDEFIIFIPDIEDEKW
LYRKLQNLSRLEIDDFVCTNSMGVAVFPREAANFNLLFKKADIALYHAKISKEKPVFFSE
LDRSEQEIPLR
>A0A1C6DEL4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSSEIMSLEMDVFCLLLLIRILYQMYINREQNDHWNYFYYTIAWACVYLFMDAIWIMNVK
HLLTFNKIQSGIFNSFYFCSLAMLVCSWYVYVQKTLHSAVLKHKKILVLTFIPLIFFIGS
SLLSYWTHGLFVIDQAGNYHRGKLLPFYFLILFAYILYLSIKAGYLSKKAKNYLYQKEYK
VIVRFSFLPFITALIQITVDHLLIFNLGLTYSIFIVYNYFQQNLISLDPLTKINNREQLN
IYLTMKMKENHQKKDLYLFLLDIDQFKKINDELGHVVGDQIILKTADILKQIAHLHNCFI
SRYGGDEFIMVCERDKNEEITPVFNNLQRLFQQSYEGLPDFSVSIGYAKYDESLNYIPKF
IEKADHYMYLNKNVKK
>A0A1C5NSX3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGMRKVALITDGWRRLFTYAWPAGILQRIRETGEDVNLYIFNSTGNWSRDAGYNRAEYNI
YNLPELSDFDGIILELNNISSPAVLADVISNAKRSGRPVVSIANELGDFYYVGIDNYSAM
KQVIAHLHEVHDCKKFWLLVGAQDNYESSCRLQGMLDYAKEHKIKIDKDDIWYGSFDYKS
GLEGYKHLWDRHKELPDAVICINDNVAVAVCEAAAQMGFHAPADFRITGFDNFDKAGFYT
PSITTVGHIQEEAAYQGMDVLLRLWAGENVPKYNFTETEMLWQESCGCGKGSSRDARAHL
KDQIMYSVESEEFDEEVLSMEAEMMQCNTVEEMMYCIPQCIPSLKCDAMYLVLDDHLNAY
KKEAEKSIHLDAAPSDEGFYVHGYPRQMQMTFAYERDQRLDLDRQEVDGIFPTFDYPKPG
QDFLFLPLHFGERTVGYVVIRNAVYLMKKQYLFQIMNALTRSMENLHKKEMLAYMNKKLS
SLYIMDTLTGMYNRMGYQQLGEKAFQISKRNHRKLLILFVDLDRLKYINDTFGHEYGDMA
ICAAARALMQCSSRDAVPARTGGDEFVLVQTYQSDEASRDLVHRIRRTLEAEGKAQKLPF
PLTMSIGTVVTDPDSNLTFADYVKQADSLMYEEKVQKRAARK
>A0A245ZNT8|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MRLYRASSFIFPRSLQLRLFAVCFVGTHLPLTAFLVWATITGQLDLLGVLLVTGATLIGT
IIAVGGIYALLAPIDVAARALNDAENGEIALVPTVGGTDLAARLLAGVNRAAGATAERVR
KLSREASVDPLTNVLNRRGLLQELDALTEQETTGALALVDMDHFKLVNDQLGHDTGDRVL
RDFARVLSGTVRQTDFVARWGGEEFLVYFRGATEAQAQSVLMRIAERIRNEPLAHLGERP
LTFSAGTTAASRRTLDESLRRADAALYEAKHRGRARILSNAELG
>A0A7W5DHD0|diguanylate cyclase|EC 2.7.7.65|Halomonas fontilapidosi|TrEMBL
MPERRIRFSRGFAAWYAGGALLLLGMALWLYLMGDYSRTPLPAALFLLMLVATLLSATRE
EPSRLAAYLALICGYLLIAVELPLQSGLPALWVGLPPVLTLLLLPLGPAMLLNLALTPVW
LSLLGNGELDRPMLLSYLTLVIVAALVPWEQVRQHALLRATDPRDPECPAVERETLHERL
LSEAERASLLEQPLAVLLVHLPQLEMAGEQFGAQARQALLNGFCQAVDRCCREHDILGRE
GPGDFWLVLPDTTESGALLVQQRLDQVVAQTTLVETGQMQVRRRLCRPRLGESWQRFEQR
LQAVSQSLADG
>A0A3R0XA63|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADLLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLKLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTLLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTKEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGISVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3R0JK96|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSECIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAVDPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLGGCRIIFSQVGRDLQIFNSLKA
NMADYLLLDDELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A7Z7HNV5|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MDDALTDDPDEHPDEPPALMRRKLAQQVFRWIPWLVLLLSLSFTGLAWRNALVAQERYEQ
TQFDFQVRAVLTRIEQRMQAYQQTLLSVRGLFEASKDVDRQKFRRFVDSLHLTEIYPGIQ
GLGFSRLIAPAELERHIDAVRREGFAGYTVQPAGPRDVYSAIVFLEPFSGRNLRAFGYDM
YSEPVRQAAMVRARDSGEAALSGKVRLMQEAGREEQAGLLMYVPVYRNDAPQSTPVERQA
ALLGWAYAPFRMRDLMNGIQGGRMGELDIEIYDGEHPLPEALLYDSYRENLTSYAEMHVS
REHRLGASHTLTIAGHPWTVISRPAPGFLQHVKDRQQPVHTALLGLAISGMLFWLSWVLI
NGRRQALQAAHGMTRELRESEARFRLLADSVPALIWLADTDRRFYWFNRPWLEFTGRSLD
KEQGYGWTDGIHPEDIKRYLDTYYASFDQRQPYTIELRLRHHDGDWRWIADHGIPRFKNN
DSNDEFIGYIGSCTDINERKLMEKALQRSEENFRRQSRTMAEILWGADVGTWEWNVQTGE
TSFNQRWAEIVGYRLEELAPINITTWHHLTHPDDLKRSNLMLQRCFRRELDAYECEVRMQ
HSDGHWVWVLDRGRVVEWAEDGQPLRMSGTHLDITARKQSEIRLQLAANVFTHAREAIVI
ADTDGTIIDVNEAFIRITGYTREEALGNNPRMLQSGLQDADFYDEFWETLLSKGHWSGEI
WNRRKDGEVYPTLMTISAVRDANGRPQNYVALSTDITAIKNYQSKLEHIAHYDVLTGLPN
RALLADRMRHALSQCLRRDDALAVVYLDLDGFKAVNDRHGHEIGDELLVHVARRMQEALR
EGDTLARIGGDEFIAVLVDLDEPSHCEPILERLLQAAADPVNLRGYALNVSVSIGITLFP
VDRTDADQLIRHADHAMYQAKQAGRNCYRFFAPTPNAEEPPEE
>A0A2S8DDB2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIACELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A8H8ZEA4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A1G0EU22|diguanylate cyclase|EC 2.7.7.65|Gallionellales bacterium RIFCSPHIGHO2_02_FULL_57_16|TrEMBL
MTKLNKSDEFTADWQRLAQETSLSVKQTVGALVQQHAGDLADLFYKNMLADDEARQFLDN
DLVNQRLHASLQHWLIELFSDAQKDPHEIYKHQCRIGEVHARIQVPISLVMHGARLLKHT
IHDYLVLSHLEREELVKATSYVAETIGLALDTITDYFIIDMEKHTRADEAYRMFALGQNM
MAERERQRAALLEWAQQILFKLLAGGTEAELPGIGNSEFGMWLFHKAAIIFESAPELERI
RQRIEQVEKTLFPKLVESRRSSVDTSLLMKEIEAGISEIKFLLGGLFDRFIEMESGRDAL
THLLNRRFLPAVLTREMAMARRSEVPFSLLLLDLDRFKIINDTYGHAAGDLVLQQAADLI
TGSVRAGDFVFRYGGEEILIVLVEVDKERAMRVAETIREKVASEQMQVGEDRTASITVSI
GVATYNGHPDYETMMKDADGALYQAKEAGRNRCVASER
>A0A1M5ZNW3|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MYPLKGNEKAVGLDFRTVPAQYKTVQMARETKQVVIAGPLELVQGGRGLIARYPIFTDLP
YNNNYWGGLSVVINYDRLIETSGLHQLQGVEVAIVADTHDGMGERVIEGDASVLTQFDMS
YPIYLPNDAWTLFARYQNLSDIESISRFRHVFVSLGIVTFVAGYILMMFFISNYLRAHNL
SLHDELTQLPNRRYLFSELNLLMARKGAWVEFTVLNIDLNKFKEINDSLGHEAGDQVLKH
MALSLQKCLRTTDFISRVGGDEFIIVLRRTSKKEDVELIIRKIHLFLESRPLHWNNDKIW
LSLSIGFHIFKGKADPKLIQEILSIADKKMYEDKTLKHTEL
>A0A1M5ZTL3|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MCRWAVNHPEKSVAGIAIKGFYMCQKYLSGWLQTITQYALFLVALLMLSALSDTAAAPSD
EIRISQLTATNGLPSNVVHDGLQDSRGFIWISGASGLIRYSPHEIRVFSRDPDDKHSLIS
NSINVIFEDSQGNLWVGTKSGLARFDRDSETFENFTHHPAQPASLSDNHIRAVYEDHSGV
IWIGSEGGLDRLVPAGNKTWRIERTDYFPARPQITINAIVQDRTMRYWLGTDHGLYCWNP
KTEQLRHFMHEPDEADSLSDNYVQVLEYTASGQLWIGTLNGGLNLLEEGKETFVHFRHDP
GDPDSLRSNDVRDITGDKQGWIWVATTGGVNRIHDGQITRYLFRPGQIFHGAHDIHSTEI
AFVTSLWQDSHGRIWFGTLGAGIYIRDPNLKLFDNYLYGHDGYGLSARHIRGMAEDASGH
IWFGTHADGLYQFDPMMEKLTVYQSVDSRDDSLSTNRVAAVIEGDQGVMWIGTGGGGLNK
YDPKTRRFKHYVYSADESGKPDAADGLPHNFIPWLVKDDEGLLWLAHFGGGLTRFDPQTE
KFTNYRHDPNDRKSIGFDILTSVTPLHNGEIWVGTYGKGISVLDPQTKQFRHYRHHPGEP
GSLSDDTVRHIFEDSRGRIWVTTNLGLNQYFPDQDIFRTYTTKNGFPDNNLLAVVEDNQG
LLWISSPKALTRFNPDTEAVRVYSQADGLGVNSFFFYAFGRTRDGRLMFGGDNGFSMFDP
MQIKDNLNPPDVVLTRLEIFHRPAEIGPDKPLTRSITETRSLVLPHDQNSLSIHFAGLNY
TVPSKNLYLHKLEGVDKHWVKTGSDRPFAVYNNLAPGQYTFLVRAANNDGIWSNQVVRLQ
LKIMPPWWQTWWFGLLLLMMAVFLLRTIVLWRIRLIAQQNRYLESQVKFRTEALEVSEAR
FRGLSEATFEGIFIHEQLKILEVNQYACDLFGYEREELLGQSSRMLLADETFETVRNNVL
QGVECSYEALGRRKDGSVFPLEIHAKQIPFRNDFVRVAAVRDITERKRFEAELIRLTLTD
QLTGIANRKHLDTQMQQEIERARRHRVPFVIIFVDIDSFKRVNDVHGHLVGDAVLQEVAL
RLKQRLRSTDLPGRWGGEEFMIICPETQAEAGRELAEELRAIVSQSEFPGAGRVTASFGV
TQYQPDESGDAMIQRADDALYHSKKLGRNCVTLR
>A0A0H4W5P1|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MTLNLSATQVLTLGSPAIALVISGSFLCIWKFLDRRAYLALLACAFLLYAAGAAMQILQW
PQDRDLNATIPAAIYLLSIACMTEGLLRRYGQHAGYPLALACLAIWMTVAYFCYVSPDAD
ARSYVLNFGIGAILCAAAWRIRGARRASHIDKTVYWVFALFALSFFARTLLTLALPVYFV
PQLLGSLAFWFVLQLTLVLTGLVLALLLFAASLADMIARLRDDRDLDGLTGLWNRRALDE
RLEALIARAGQRPYALLLIDIDHFKSINDRYGHAVGDHVLRVVSSLIRDCAGNDALTGRV
GGEEFAIVVPAELSAAYLLAQRLSRVLAETRIAELDEDHVITASTGLTMLQLGDTVSLWM
RRADTLLYQAKRDGRNRVVLQPAAA
>A0A1M6DEJ9|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MTTGKKITARKYSLMLLAMTAGKYLNTITILLGIALLTVDITGSSLFSQIHPSLAATNPV
AIVIALMLCMSHLFYQVKFHQPIFLLSVVLLAGLISFFDFGFNFFFHDKVITLTGFLLSQ
MADGQFDAIGNNMILTCMFYIVAVMLRLRQKYYAFQFFTLTGLAIPFTASLGYFFDAQQL
YFQMSVSTVIICFMVALSGLGMTANKGAIKLFMTPNLVGTVARMQFLFSLSFCLIVGIAL
PHLSDQMDLLSAYELFVTLAAIFMSVLIYISTIILGKSEQKKRLAEKEMQRLLVTDPLTG
LYNRRGLEYEIQKALNAQSRYGGDISILILDLDHFKSVNDNFGHDTGDLFLKTAAAVFKS
EVRKHDIVSRYGGEEFLVLLPNTPEQEAKTTAERLRMALESKDFGILCGQPYRQTVSIGG
TTIPASRPDISSSIKLADRMLYQAKNDGRNRSVIYQHCGK
>A0A378GKM8|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MLIKFPLQRFLIYLTITLIGTLVLNHFSNAIISHAPAIAPILFPTLTMFLMVFHTMIAVF
MIMKYLCDKRRLYLMPIACAFASSALLMLGTLKSYPDWFLCGGVTNTNYNDALIFYVFRN
ILMAVLFMSSVILYMFKLRDMHTRKIHAFILGGIIIFCVIIIEFAWLYSSNNQLLSVNFI
DNLTFKYTNIWKDVISWILIGIWVITLLSILLVTQLRNIFWYSGAFFCACYIFTMFVLMT
GQDTASYSWYQARLFETISTLFLIFVLFCDVFTLYRQSNVKYQNSYQNSIRDPLTRLYNR
SYFYDSFTALRPTIADGHPVSVIVSDLDYFKRINDKYGHLQGDKVIQFVAKVLQDSVRQN
DVAARIGGEEFALLLVNTTPEVAHSIAERIRIAISQHDIHSSNAQLPESITISMGVFTAI
DLSVPVEECVRRADEAMYRAKAAGRNRVVVWESVE
>A0A7W8HVB0|diguanylate cyclase|EC 2.7.7.65|Brevundimonas basaltis|TrEMBL
MTARILVVDDVEPNVRLLEAKLTLEYYEVLTAMDGATALEIAAAERPDIILLDVMMPGMD
GFETCKRLKADPVTRHIPVVLVTALDGREDKIKGLGAGADDFVTKPIDDVILFARVKSLV
RLKAVMDELREREESGRRLGVDADGAGRLRGSGGRVLIVDDNELQAEKMVTHLGGEHRPV
VETDPAAALIAGRGPIDLMIVNVSSSGFDGLRFVAQARSSEASRRTPILAVVDPADRPRL
LKALELGVNDILPRPVDSEELMARARTQIRRKRYADFLKEKLDYSLEMAVTDALTGLHNR
RYMAGQLQAMVGRAAQGGDPVAVLVMDIDHFKVVNDSFGHDAGDEVLREFAVRLATNVRA
IDLPCRFGGEEFVVVMPGATLEAASRVADRIRRDIEAQPFPIMGGAEGLTITVSIGVAAS
IAGDTPEALLKRGDEGVYEAKSQGRNQVISRAA
>A0A174G0U2|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MRKKNEITEYVAAALIFVCAVAVSLGIFLVCTQNSIERNSQKVIKTNVSRQSEHIKAILD
IHYGYLRGIAKEIGKSEELVSDENMEMLISLEEETALERTALIEADGTAHYDNGAEKNVS
LRRYFKEGMEGKETLSDPLESSVDKETRVILGVPVWKNGKVIGVLGGSYNVTALSRMLFN
DFFEDVGYTLITTSDGEIIAYDGDFAYHEIEYGDNFFEFYDDQTLIFDSSLTEVKKDFTV
GADGLMKIRIGNDYNSDRYLAYTDMGLNDWMICYVIPVSEAQKSYNFVRRYELIFTIGFC
VMVSMLFLWGFVKNRSKDKQLIQAAETDALTSAYNKRSTEERIHNVLQEHPQEPGTFVIM
DVDHFKEVNDIYGHITGDKVLHKFGEVLHEHFREGDIVGRIGGDEFVVYMRKTDSREVAV
SRIESLIKKVEELSFTEMNGKNITISAGMAFAPEHGTGYLDLYKNADTALYKTKQNGRDG
YNIYEEEKR
>A0A5E6XSM8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAKTGGNGFSLARRLYTSRILGVALGLVCVSAAMYPLDPAPWVWGFMWFNGVIWPHLAYQ
LARRAKKPYHAEHRNLLIDAFLGGFWIAAMHFNPLPSATTISMMAMNNVAIGGMRFLLAG
TAAQLLGVGVGLQLFAPAFIPATSPLQLYACLPLLCLYPLALGWICFRQAHTLGRQKREL
LALSRTDSLTGLLNHGTWKDQLEVEFQRCKRQQKGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNRAAVVMDALRDRFATLGYEQNPA
LKVSLSIGLASFNPAHTDATLWLNDADHALYEAKTTGRNRVICCGNGKPCGSGLAREGAS
TFNINDA
>A0A174WBN6|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKTIIKYELVINEALKSALNYHTPDEQINEFIRFFGRHIGSDRIYIFEDCKERHGTYNTY
EWCAQGVTPEIDRLQNVDMDVIKWWYDTFSRGESIIITDIEDIKEEHRVSYDMLKAQNVR
NVVVCPLRYKDEISGFFGVDNPPKSDYRGLTTFLDMIGTLLISFLKLRNSFIKSNKEAKL
SSYSSLSKIYASMYLVDVQTKRYHIIKMTDQIAEYLGKDFKMGEYEIRDDFCGYIKNIAE
KMCTESQLQESLEFVDISTLEERLLGENSITHEFTDKISGWNRSRFIPVDYDEDGKLLHV
LFCIECIEEEKKRENRLIYLAQTDLMTGLCNRGSGEKKITEFLKKKTGGLLCLIDCDKFK
SINDNYGHSVGDKVIIAVAEKLQKTCRDSDVVLRLGGDEFAMFIPGMLEQRVAEKFFERF
FENIRQIDIIEMQGKNIEISLGACFYDGYEEVSFDQLYRKADRAMYQSKKQKGCSAVIYG
EEM
>A0A5E7DPE9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGKTGGKGLSLARRLYASRSLGLAAGLVCVAAAMYPLDPAPWVWAIMLFNGIFWPHLAYL
WSRRATVPYHAEHRNLLIDAFLGGFWVAAMQFNPLPSAATIAMMAMNNVAIGGLRFLLVG
TVAQILGVIVGFFLFTPAFIPETSQLQLYACLPLLCLYPLALGWICFRQATTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCKRQNRGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKVLKQNLRATDVAGRYGGDEFCVILPDLALNSAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFTPAHTDATLWLNDADQALYQAKATGRNRVICSGDGEPHHELLDSV
>A0A0D0SMA9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKTPTQTNAIDFDSAKLQRLGLGQPSLRPRRPATLTELRQQLSQQLQTSLEPERILSLFF
REIQRLVPLDALQYRHVASDLRLEFGHRGHHSVSYTLSHEGEHLGELVLRRNQRLIEEEL
HQLEALLVTLLYPMRNALLYRAATRSALRDPLTETGNRVAMDQTLQREIDMARRHLHPLS
LLMLDIDHFKKINDTHGHAAGDSVLRAVAGAIKRQLRNVDMVFRFGGEEFLILLSNTGRE
AARMVGERLRQAAQAQDYWVEGTRIELTVSLGCSTLLAAESAESLLRRADNALYVAKREG
RNRLAMAG
>A0A109L913|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MVHEKPSLPDVPTAEPPRPAAAATLLALMHAQGEVERLSEREQLLSSLLVSVNAVLWAID
WETRRVLYVSPAYERLFGRSAGLLLADHREWRNSVHPEDLDYAEHSLARVLEQGAVEDRE
YRIITADGQIRWLSDKCYINQQVVPGEALIVVGIAEDITEKKQLELELHRLATTDVLTQS
SNRRHFFELANQAFDNACVQGTPLAFLLLDIDDFKDINDTYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCPPEMALQVAERLGKEIQALVFSYEGHEFNVTVSQGLAG
LREDDSTLDSLFARADAAMYEAKRQGKNRVIAG
>A0A7K4EEI4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida CSV86|TrEMBL
MPSVSPEVQAREWHSMVAQFPDALTHALKGLVETHKATLAARFYEQMLADPNASLILSHE
DVKSRLGSSMQAWLVKVYSARAGDDFLPLVALQKQVGEVHARIDVPLHLVLGGARYLKKQ
LYQLIAEQGWAAQEHAQILRLASETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNI
TTERERQRGALLDWENSLMFDLAMGASGANLPRLAAADFGLWFRHKGAYAFQNTRESEQI
LAIIRHVDDELLPRFLAAAGDEAARMSLLREIRDRTKSLMFNLDSLFNSANELESGRDVL
TRMLNRKFLPVVIGNEIAIAQKTGQRFSVLSVDIDHFKSINDRFGHDAGDLVLQQAAEIL
SSHSRAGDYVFRMGGEEFLMILVDINNANALKVAEKLRHKIGAETFNLTEGRKHRLTVSI
GVATYSGHPDYQHLLRQADQAMYQAKQGGRDRVVSYDTLDG
>A0A1C5YJL1|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKQNIKRLLPVSIVIGITIIVSIFLYHKVMDREEERCWQILSDSAKTISAEIQMKFQDNI
TTLGLAANAMVEENKLEPEQIASVHLDAFAKNTIFSRIDVLYPDNTILYEDGHLKHLRQD
LNFNAIAALGEHISHRLTDSETGNESFYYYMPVIKSDEIKAILTGVIDTTVLADVFQSSF
YDGHTAICLVDSADGNYALDTRYSTLGNAYDTPGPALLKGYENIDLKNEVKSLKTGVIAF
NSSINGKDNYMHYSPVGMFDWELLVIAQEDVVFSSLLYLKKLMILAGIIEFLLLGLYIAW
NFYTVEQLAKSEKRTQEQLKNSNTLIQCVTELSSDKDINISIQNLLGIITQYFDSDRTYI
FELNPEKTMLRNTYEYVKGGVSVQIDNLQEVPITVLPKWMESFLKFEPYYISDLEQERGS
ESYNMLKEQDVNRLIAVPLGKRGDVIGFVGVDNPRQFYNDATLLSSIQFFLTNSLATKKQ
QEQLQYMSYRDMLTFLFNRNKYIKILDSHQGKILENVGTAYIDLNGLKQINDSQGHEAGD
AFIQNAARVLSRVFPDKVYRIGGDEFVIIQSSIEELEFHNRINRLQEYMKQDQISISIGF
LWKASCENLENMLKEADHRMYEAKKAYYQTADRRTHNH
>A0A8B6X948|diguanylate cyclase|EC 2.7.7.65|Derxia gummosa DSM 723|TrEMBL
MTRLRRLPLAAWLALNALVTVVLTVAAITLVIEHSTDDAGLLLRMRWTAGLVLAAALPLS
IGFGHLFARPLRRIVRALGEEMPPPGVTDGVHYREAGQLARAVHGLLDQLRGHRQALDAV
TASLEQRVALRTRELSEANARLGDTQKRLTEITENVPALITYVDRDYRNQYANATLKAWT
GIDPAQAVGKPLIELMGAAKFALRKPAMDRALAGERVRFTEEWRTGDELRHIDVVYVPHR
DASGEVIGMYGLSTDMTAIHRAEAMLQRLARRDALTDLHNRLALGEMLPEALARARASLA
DVALLFIDVDRFKRVNDTLGHAAGDEVLRQFAQRLLGCVRTTDTVARLAGDEFVIVLENL
PHADDAEVVARKIVAAMAEPMLVQGHELTAGASIGIAHAPAGKGTPEELLAQADRALYEV
KRNGRGLWRMAPLPASAPAPAIGIEHLSDDIAGLAAAAI
>A0A736MJ58|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z36[z38]:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQEFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A5C5Z5H6|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MANLRNRTGPPERDPLTAFAIAKEALDYVTKFRTPPTPDIYKVWYHYVEGEPGELREQLS
HAVNEAKSVSYEQLQLLHQQFFAGSDERELTQKLGEDLATTIGTVDSIIHEQLSAGNTFK
DSVHKASENLSVEKTTVEELKSCIESVLASNQCMQDQLDRMGVRLEESRSQVTKLRASYL
DSQRKLMTDPLTNIGNRLFFDTMMSNALEHHERGERHFVLLLVDLDKFKLINDTFGHATG
DTVLRFAASNIEQIAVDASVARYGGDEFAIFFNTLDSAKGMELGETICQSFAQNKLTLND
TGEPIGKLTASIGGALLREDDGEQSWFQRADKLLYDAKNGGRNRAMVERKIN
>A0A5P9JNP3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MPSLLDLLRNRLTTLLPSELRPSELRHLLDPRRHPVLLCQRRATLIVNRVRLFAFLFAVL
TPLWSLIDLMVFEPKLWLALAGLRMMACLAFTGLLLFYRPSGNLLDAYRAIAILFAIPTA
FYIASHTLLGSYQLAQFSAVVGAGYAFLPFVLMAGLTIFPLTLVENLVLSSLLLLAQALA
GYLSWATLNWPSFAGAFWLLILIAGVASLASMSQLAFMIALVRQAIRDPLTGVFSRGSGE
EILRLQWDSAQRKDSALALAFIDLDHFKSINDNYGHEAGDQVLREAARRLVATLRSSDSL
LRWGGEEFLLIMPETDMEQAHKAIERIVGEGLGVRPDGLALTASIGLAERRDDQVDDYRD
LLELADRRMYLAKTGGRNRLCAAESEKPQHQRALALES
>G2FH82|diguanylate cyclase|EC 2.7.7.65|endosymbiont of Tevnia jerichonana|TrEMBL
MELLQQHQIPPSPVCYAVAYEYVAQRTPTLNQALDQHLEKHGSLNPHLLREFFETHFEGG
TELQLDDHIASLHDTLYKVLEGVSSACHGISDFGRLLEGQMESLQGQTDLGSVRRIADTL
LQATNQAISNNQKIQDNLASAERNTTELRNQVEQLREEAHRDSLTGLYNKKVLNQRLSQC
IESSIESQTTLSVLMLDIDHFKHFNDSFGHLIGDEVIRRVAQTLQQRARKNDIAARYGGE
EFTLVLPNTSLEDAIKVAEMIRSTVGKLVLVRKSTKEKLPGITISVGVASLHPEDSIETL
LERADQALYYAKNHGRNCTISESLLITETDSNNQKIAY
>A0A231H1C5|diguanylate cyclase|EC 2.7.7.65|Nocardia cerradoensis|TrEMBL
MNGGKTLRAWWNDPVDYCWLIRSLTARSALGPLKVLVGVAGAMIAAMGAVITGSPVGPPG
HPGIASTVGVSCGTLWALRWWLLRWPGRTESLLLIGGADVLFILEFLQVPDRLFAAMGTV
LLVVTGSYLGFFHNARVLAAHSAWSLLAVIVMSVRIATGGGQLRLAVAVGLLLFVSVVSA
VPALQILYWLLRTESMSDPLTELLNRRGLEIRLPLLVDQHPAISVMTFDLDKFKSVNDTW
GHRVGDTVLVRTARRLHEAAGRTAVVARAGGEEFVVATPIAAGAAHAEAERLRRIVAEPS
GTTVEVTASVGVAVYDAATCPRCPRPTPDRLLQSADAAMYRAKQAGGNLVVVEDLTPPPD
HHRATR
>A0A8H9NST0|diguanylate cyclase|EC 2.7.7.65|Citrobacter farmeri|TrEMBL
MPHETTMENWGWLKTLARRLGPGHVVNLCFLTVMLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQFNVDKLLFLRDGMHEALITPLGFSVLKDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDSFVNQTQLLSRDNESLDNELTAALELGYLLRLAVTRASLSLQAMYVSRA
GFYVSTLPTSLSSEITARYYDYVIQPWFTGQSQRKNRTRGVRWFTSPSSEFSYAQQRVTV
SVPLDSNHYWLGVLAMSIPVSAVERFMDEAIDKDVEGEYQLYDSKLKLLAASTPELRNAK
TFDERELALLAHDIEQDTVGGLRMGSRYVSWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKQLT
QRCRMQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRQRLNEKEILVAKSATLRISASLGVSSTQETGDYDFEQLQ
SLADRRLYKAKQAGRNRVCAVDRG
>A0A1X3JVU7|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii B156|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVTHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VEKQLKNAMEHWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIEIIYKVLLDSDLGGSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LVQDFDGIFQQTMRNSKNLSNKSLRVKFLLQIRNSVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRSGTPLSVLIIDVDKFKEINDTWGHNTGDDILRKVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEASETDTLRTAERIRSRVEKTKLKAANGDDIPLSLSI
GVAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6W0M5B3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Duisburg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A4R8S045|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MRPQAGVAGSNPAEGTLIIVGHTPRLSPQPHYYRVRNTQFRIRNTQCGPLPHNEPVRSNP
RLRPRRRRTPEQEYRFVTGALGPRNLRHLKRAIGLLCMSILPLGTIVNMHPLGPQGAGRT
IHQSLIAVSFLVGVCWMVRPWPSRRWAISFVTWADLSFAVSAWMYAGPMMRLAPILYMST
VGVFAAFLLGWRVLAVHCVFASAVLGSITLWNIHTGAATFLDQFLYNAPAFTTVVLLPIL
IQAVIEGGRRSIRAAVTAANRDPLTGLLNRRGVQSTFEFELRKRPGPATVVVMVTDVDRF
KELNDTYGHEAGDRALQAIADALFANIRDGDIAARIGGDEFMVVAFVDNSDDIAAINARI
RNAPIRTDTPETSMSIGIAWSSTDAEDFSFESLTREADFRLYEAKRDRAPRGSTA
>D6CKR2|diguanylate cyclase|EC 2.7.7.65|Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As)|TrEMBL
MRPQRLSTWFSGSRLGRQLFALFVVAALVPLALSDWLSSTAVNQVARQLNMQSQQRMTRQ
VSRQVFDRLLTAKTLLLALPSSAPQADAQLPVLGRAFDALLLQTPQGKPEWASANAANLW
RNWQRAFPAIPPVQPLMDASAGLTQVLLRTHRATGEPTRVYLATLQNGQPRWIAELNPQF
LWGPVHDAMDGGVWSVRDVEGTSLYPVANVTAPAAQRGTAADSVFRFQLFLGGEFGAPDW
LFIQQAPPPRVSWLGWPLAVWLGLVAAATLLLIALLAQRQIRRTLVPLEQLTAGTRSLAA
GDNCARVQVHSQDEFGVLAGAFNDMAAKIGAQFHALEGLAAMDRDILSGASVDSLARRVL
DQLEGLYPKASAAVIWQKEPQNFRRAVLWHDGKTNKTVFDVRDVACDATAQAQWSALQGD
RQFQINSPGENALRDTPCLRSLMPPADDWVALLPLRQGDVMPALIALGLPAEPAASELQP
AAEVRDRLAVGLAAQDRERALVHQATHDSLTGLLNRHGLHEKLDALLAPGQAAAPLALLY
IDLDNFKDVNDSRGHAAGDALLCQASERLRTRLQANGIVARQGGDEFTLVLPLADAATAQ
ATADAMIRALREPFELAGGPVQVGASVGIALCPQHACERNELLRCADIALYAAKAYGRGR
AQLFNPTLDAEARTLAQLLADLRQALVRGEFVAHYQPRVNAGDGRITSAEALIRWHHPQR
GLLFPDAFIAVAESYGLIAPIGRWILDAACQQMAQWRREGIDIARVSVNVSAVQFESGEL
VGQVQNALERHAVPPATLELEITESLLVDENDALFAQLTALRDMGVTLALDDFGTGYSSM
AALRKLPIDVMKIDRSFVIDLETDASALPAVRAIVALAQASHLHLVAEGVETETQARMLR
ELGCHELQGYLYSRPVEPSKFLQLPGLRHGAPAA
>A0A702BB44|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Eastbourne|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A395LB25|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MMGVVTLGDVDRQIGRGFRFLRFSRDIEAAFLRDYATSRVRLAVVWAVIGTLIYDSVYFG
DATMMPDVFWPLVFVRFGIFTPFALISVLALRRWPSARNYDLLAISVAVLGVSLPMSVAV
FSNSPYLFVYQNGNVAAFLFFVIALRPRFLTIMIGLVLMCAVQFTTTKLSGAFDDVVYTG
IVTFYVTLAIFLAMSAYFMEHKDRLNFLHQLRGSLLHAELERKSERDELTGLLNRHSLAR
VRQTIWNEQGAAATVAVIMLDIDRFKLFNDVHGHIEGDDCLRAVCRCILREVAGAGETFR
FGGEEILVLMSEVEREDARDMAERIRVAIEALGIRNRGLADGQVVTASLGVVLGKPNEAS
LEDLLRAADAALYEAKRGGRNTVSLFDGTWRGPTGAGPGEKPGELSILLAS
>A0A0Q8X5T6|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. Root83|TrEMBL
MSSSSTGVPSSSAGADAANGQACYLSASNAQAWEAVYHSVDAYTRGQVAAVVADSAAQFV
DAFYSTLLADAEAGPRLSHEIVSTRLHSGMTRWLKGLFCVRDQGDIAALLATQKKVGEVH
ARVHIPIHLVMAGARILKNEIALRLRASDLDGTAASVATQYVCNLFDLAIEQMSRAFMRD
TNRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFG
LWLQHKGGVLFESAPALRQITEAVARLDEAVLPRMMQGDADGQHSLPDQVRELQELVARI
KHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREISISRRQHSDFSVLLLDIDYFKA
INDAHGHAGGDQVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGQEAALATAEKLGA
EIRRHRFSIAEAGSLHVTASIGVATFDGHPDYAYLIDRADKALYLAKQAGRDRSVAA
>A0A7V8PMA5|diguanylate cyclase|EC 2.7.7.65|Pectobacterium sp. CFBP8739|TrEMBL
MNELLNVNEQRDYGELDYNQVITSEWMQLIATTSQKSFNLLRTLSDQKTSDFADEFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNTGEHLTDLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVTEDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIHTIASIMTETDEYIRGYSTTALLTQQDYAPLLKAVRSKIYKINMLLGSLFN
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTPLSIAMIDIDHFKTVNDTYGHTA
GDNILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAYTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYGGHPDYECLIKAADDALYQAKANGRNRIEYALEE
>A0A210P7K7|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MGNLTEILRICFSANALVTGIVTIGLVTIITYISFVLERKVSTASSFFRKVGINMAEMFL
LFLMLLLVTIVFKSLTGGSQVELGGLLANAELTILFYGLFIFNNRLIVLLNVFLPFLYHP
SSDISRIQGPYSWLFISSYLILIVVIDYLYSHKDVLAISNYRYLLSQMLFGICWWIFIWI
DYKFPLVDIIGMLILFEIYMFIVRIIELKMSTYMHAYNDLENKVNYDALTGVRNRANLNK
ISKEVFEKFSQSSVPLTVMMFDIDHFKEFNDHYGHEIGDEVLRHVSHTVERELHVDGSRG
QLFRYGGEEFVILLRNTDTHKAQEIVNRINQTLVGMPLFIQETQLDVTLCFGVTMLRKTD
NSFDDIFKRVDEYLYQSKNNGRDEMTIEGKIFQYEKVPIIKI
>A0A3R8ZXW0|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. 198|TrEMBL
MTTDTFSPADRSSLPWLRGAMFGVLSFVLTLFCLELIKVSIQISSLWLPTALMTLLVFHY
PPRRLPGLLGGCMIGIIAANTLMVGTAVVVLTFPLINLLQALLGGALLRRLLDREAPLDS
LLGWSKMVVSVGIFTPLLGALLACWSLNFTGQANFHFFTTWTVSETIGMLALGPVCLLWR
PEELRKSLSPHALVETLLTLIVTLALSYCALRYLPWSFTFVMVVLFYSAVRLPRLSAFIV
FFATLLMMSLLLALNQLVQYTNAVTIVNSAPWLPFLLAIIPSHIMAQVMHSFREEKKHIS
QSEARFRHAMEYSVIGMALVSPEGRFLQVNQSLCRLLGYAQTELVTMTFQVLTHPDDLAV
DESKFNELLAGEIETYSHEKRYLRKDGRIVWALLATSLVRDSERRPLYFISQIEDISDLK
QTEAANRRLMQRITLANEAAGIGVWDLSLKTGKMNWDKRMFQLYGLKEEGQATYLTWVNS
LLPADRQMAIDAFDKGIKESLPVDIVFRIATDDGIRFIHSQSTLVFGDDGNVERMLGINQ
DVTAMRQLTDALYQEKERMHITLDAIGEAVISTDEEMRVTFMNPVAEVMSGWTQEEAAGK
RLSDLLRITHGSDGPEMENLLLCGLPHSKSAPELAEELVLHNRSGDCFDIHYSITPLKTL
EGGYIGSVMVIQDVSESREMMRRLSYGASHDMLTRLPNRVSFEQRLKQLLHSASQQQRQH
ALIFIDLDRFKAVNDSAGHAAGDALLREISGQMKQHLRSGDFLARLGGDEFGVLLPDCAP
GEARDIAQCLVEAVNHYPFLWEGQLHRIGASAGITQLSKDNASASDVMAQADLACYNAKH
NGRGQYSIYEAKLIDTLKPVLSQRENQQILPQQLSS
>A0A3R8ZHC9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRSFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMRDALQTPLAFDVLRAAVTRFNADRTRPFWQLAVDT
KRTLPINGVSDAFVEKTTLLNRDNELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTDTPAQSADIIPRYYHLVTQPWFTQQTERNNRARAVLWFISTPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRLLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIESDTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVLA
KQCQAQSLPLSVIQLDLDHFKNINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKEILVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDQDRK
>A0A1W6K483|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MEKIQGRHMPLRRSLWIVGIYLLVGWLWITFSDYLVQQWFPDPETLSRVQTYKGAFFVLV
TALVLFLSLIRQFVSDRTLLSLNVRQQEEIRELNQFRESVIERANVWINVLDPEGRVVLW
NKAAEDISGYPREEVMDSGAIWQWLYPEEENRVRIRERANEILRDEGEVVGYETWITTRN
GRERQLSWNSRSLRNDAGEITGSIAIGQDITDIREAENTLRWRERQLSTIMDNLPGMAYR
CRYDEFWTMLSVSNGCLELTGYEPHELVNNSLVSYAKLIDEACNETILRTVESAIGNAEP
FSIEYPITRKDGRKIWVWERGRGVEGEGELVLEGIILDISDRKELEEELSELATRDSLTG
VLNRREMTRILEEEIARAKRYDRELALLWIDFDHFKAINDDHGHAAGDSVLKAASALLAG
SVRSVDSVGRFGGEEFVILLPEMDRREALETAERLRGLVSDTPQPLGNGNTVAMTVSIGV
SVFPDHGESADTLCAAADRAMYQAKADGRNQVVLAPLTEEAHNP
>A0A7V7JHA4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLILAADEALYGAKRRGRNCVELWKAQ
>A0A800YHN8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae complex sp|TrEMBL
MQHDTFVVKQSFLQWLHKRSNPRLIVNFCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKILFFRHSMRDALETPLAFGVLHDAVKRFAHLRTSPSWQIAVDK
QRTLPINGVSDAFVEKTTLLNRDDEYLDNELSAALEVGYLLRLASSPSRNEERVIYVSRA
GFFLETDTPGNSSDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSTFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTQLATSESPAADVN
HFDARELAQVAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKMLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A8B2XUX5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. AM17-18|TrEMBL
MQRDTFVVKQYFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALQTPLGFDVLRDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEADGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLITSVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYIFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A517T4V1|diguanylate cyclase|EC 2.7.7.65|Calycomorphotria hydatis|TrEMBL
MSTVRSVDETMKAASVPEPTQAHAPSTRPTDSSRILLALVDLAKRSSVARDSIEDFDSHP
LAGIIDPGVLRALLAALANRDQRTIRHARRVARLATGVAAALGWDERPLKTLEVASLLHD
IGKIGVPDSILFKPGQLTADESELMALHHSIGTDILQACKVDPQVYEFIVQSNQYYSSTS
DGCRRLGSEAHQGARILCVADAYDSLRTDQVYREAKPHAEVMKLLNEASGSQFDGSIVAA
MERWIDQEGPGTFDPDLDGDSASRSNRVDPGSINTDQLQHIFSHLHILESLYDGFYILDA
DLKFVLWNLGAERLFGRSQQEVLGLPMSSKFLEYADRLGNELPEAEYPLQQVLAHGRPIS
AGLRYKKSDGNWRDVEIQSIPLYDNDGQLQGVAEIYRDLSRTSFRPNEYRELKMAASRDP
LTKVANRGELETQLALKLTEAAQEDPPSPFSVIFMDIDFFKKVNDNYGHQTGDEVLISAA
RLLQQECYSGELVARYGGEEFVVLCPETDLDGTVRRAERLRLAIAGATLCNQPEPKVTAS
FGISTMERGDSVESLCRRADKALYRAKETGRNRVCTLTNADIENERKPNDSKKVKVDPFL
VEGAFNAHLGADMIVYKLGGFLNGESAKLGEINQTGAVIQLGKATMFGGWGRQSQKQPVE
VVLRFDRPTKKPMHETSPETVVRFQIRPVGRIRDSKVFQGRAKQVIKSLRAYFAAADPVE
>A0A157JRS8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MEKRKKPTLERATWPTRHAMVMHGLAMNLPWLAFVNISFAVMILLRHVLLKASDPLYPHS
PQLTRMVDASMLGIIVLSAALILMAWRRIAGISAVLFICSAIWSVSCFWFITQLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPIASWIRNDGLNLHFVVIWSVFTLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKTFSV
IMLDIDYFKRYNDTYGHQAGDDCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPEN
IAEKVALRIQDGLRVESIPHSASTVSDHVTVSMGIASMAEGLAGTEIIARADAALYRAKE
AGRDRWSL
>A0A7H8UNJ5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MMNDEIYNHDQSIREAWHQQLSQDDACRSGLQFARRIRLARIAGLGALFFPLASVLVSQF
FSGGWWLFLLGWAFVWPHLAWQLAFRAADPFSSEIVNLKIDAIIAGVWVGLTGLNALPAA
ALIVTIGMNMMGSGGCRLFLTGLVLLALSALLAVHVAAIPVRLSAEPLVLWLTLPVLVVY
PVLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRGHRQATI
LLIDIDHFKNINDTWGHDVGDEAIVAITRQLQLALRAGDFIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPAARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A7W3EER8|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MIKKTAQIDAILLDLNKSIDAHYQWLVKMFRCVVAKDISHPELSDAHSHFLCRFGQWLNA
HLVMTEEEIEYVRLISLAHEEMHLQGRELLTSIAEKRWQSTDFDRFQNTLLAFTSAVMDY
KIYLLNIRSNMDILTGLPGRRVLDESFDRQLLNAEPDKFYLLLLDIDRFKSVNDTLGHLI
GDVVLRTLAENLATWMRHNESVYRYGGEEFVIMIKASTDVDACMAGLRICELIAGNQIAY
PQGELHITATAGISRAKPGETLDVVMGRSDRAMYQGKLTGRNRCMFMDENEQIRHVAAAA
TELDNPCLTVI
>A0A1Y0HML4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MQKKLSLIIVGTIFISFMLLMVISALSIRNLGIKNAEEKAQIIANLVQDGLSAHMLSGTM
AQREFFLKKISTAKGVDALWVVRSNSVINQFGKGFSNEVARDSIDEEALNSATVHKQIIE
DSGTVKLRVTTPYIATEHGTPNCMQCHQTKEGEVLGSISIVFDITEARTNGILNALMILG
FSIVIMLLVFMIINRSMRPLMEIFHSITFVMNKAQEGEYVRRVRCSSQEKEYQNVKFGIN
SLLDKLEGTLTDIEMTVKKFLALSPNHQPDLLLETQSIVHELSDIYQFKRTIEFDEDKEQ
VYHRIGSILQHDIGLKDFVLIESGKNDIHPNIVFDASSQKRSINLNCRALRTKQTVTSDQ
FRDICGLCNTSASHLCIPYLISSDLELLLSIWERTPEELTHTKTLLPKIQNYIDAARPEL
VSKNLTEILKVSSTTDALTELYNRKYLDEYIEKALSQAKRNGIIYGILMIDIDWFKMVND
TYGHDIGDRAIKALSQALKANIRESDTAFRFGGEEFLVLLYECEDAMVMQIAEKIRLAFE
KMPIQSNTSATFYKTLSVGASIFPKDSDSLLKCIKFADIALYNAKDSGRNCCKRFDPSMI
ETKELRNDF
>A0A1Y0HMK8|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MQQFKEALSTFHALCLGMILLALCILKFGLIPTYAYYFVWQSTFVFLIIALFLSIYFNKS
KLFVLLLFPLFFDLALAFPSTLFTKLSVTAFWHITPLITALGYLLLYALQERGLFSSFGA
FRTALGLIVLGIGYLGLKYFSPSMQQALDTPILHASLHGLSKASDFILIISLISLLFIFL
ISLLFEVQSQKAPFWMLLAQMIPFLFLQESNSFLLFSLVTSLIAISALVHDAYRMAYADT
LTGIPSRRALEERFLHLGSHYMIAMADIDFFKKFNDKFGHDIGDDVLKLVAKELSHIKNG
GKAYRYGGEEFTILFNGKKKEECIMALEEVRERIFRRGFVIRDKNRPEKVPQEIQKANTV
KKERLSISIGLATSSKGKTPNEIIKIADDALYKAKESGRNCLICL
>A0A653KTD7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 8I-beige|TrEMBL
MINKKQLTERSFTPSQLSGFDGAHSIQLPVDFIHDLSKADSLQAVLDTIAYWISHVFDAD
RASITLQDTEEYLKLYSISGNHAIPMDFKIPIGQTFVGRVFAQSQLIICDDLAQSDELDC
KMLLEHGMGTCMDAPMIHNGVCIGTLNVADQRKYHYTLQQAILLQSLATWLALNIKLHLQ
VQEMAVLASTDELTGTFNRRVFVQESNQTMQHFSHTRVPFTIGILDIDHFKQLNDCYGHT
AGDHVLKKMTKKIRSVLRDEDFLARIGGEEFAIILPACLGDEAMRVFKRICSTIEAMEVH
YEQEVLCFTVSIGVAEVGKHDADAEDVFKRADKALYCAKQAGRNRIHFAN
>A0A737IT99|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:b:1,5|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0N0BLL2|diguanylate cyclase|EC 2.7.7.65|Thermus aquaticus|TrEMBL
MVPFWLFFIASLVFLALFPPTAPWSERFLTPLVAVGGGAYLLRRGSLGFGLGLLFFGLGD
LFWAFADLRRLPRGLYLEFPYLIGYAAFTLALLRIPGRPPRLALALLPLGLLGLATAFQP
ELGIDRIYAVWDAALLVLLLPRLEALFVEGLDPRRALLGVGVLLFLVADMAYAYLEADGG
YPTGHPLHLLWTLGYLFVALGVGLAERFPSPFLPQALALGGLFLTPTLIMLDPSPLGVRL
LVLYGGLVGALGLLYALHLDWRRALERGRRWTRFLEALARLSPRVTQTLSPEGVLLQALE
AARELMPEVVGLEVRSRRGLVGERASHSLPIPLNGDTAYLHLKAPPKEGVPPGFLGLLGE
RIRQVLKQVEWSALALTDPLTGLLNRRGLELELPKLVALARRHGAPVSVVMMDIDRFKWV
NDTYGHPVGDEVLRRLGQIVKASVRREDLAVRYGGEEFLLFLYGADRQAAKEVVERIRSR
FRTEKIPPIPYPLTLSAGIAGGEVPEGEAVVEEWILKADYALLRAKETGRDRVTLA
>A0A8F4ZXL6|diguanylate cyclase|EC 2.7.7.65|Modestobacter sp. L9-4|TrEMBL
MSLLRPREAGEAGVRRRRGQPTPQRDSSADSRQSALVPPGPLHQQVSSALSSWQLDAAEA
LLREVDGEATAADRTAAPLTSLARAWADTLRAELLVRRLRLAGYSLLGDPLVDGGPEQDG
PLDLHDGAGPASDVPVDRDTRSESATHAALAISLVRSARAAFDAQDDDLQRAAGLARHAR
IELLSRRVDAAMDEAVEAASLLDPGLAPSPLLVHTLGSLAAVLADLELMPLALDYQRRAA
DVAAGLAGRTTGADDPADRELLTRLAGETATRLAALCAELGEGLLEDDRTEAAAPHFAEA
RDLAVRALAQLPPTDAGVLDAQVVHGWALVGLGEHAAAASLLCAVVRRAAEDRALLASAE
LGLGRALRRAGDPRAADDHLAAALALATEHGLPRLRRAALRELCTLHADLDDAARALPYL
QAYLADELDRVDERRTRWVELFGRRKSLLETERAAGQLRRQAYEDPLTHLPNRRYAEARL
DGLLSAGSVPALAVVDIDRFKAINDAAGHPGGDAVLRAVGQLLVEGCRGNDEVCRWAGDE
FVILLPDTTAEQAERAMERIRRSIAGHDWSALGVSVPVRISVGIAQAARGDDRRTLFAAA
DGVLYDAKRAGRDRVVRLSGVTQTRAAEDAAATIEGIAGTAVDTPIAAASAATATPMVGD
VTVSPRFDGPDEHDGDPADAAGGFAALLVEPPEEPPAAAAPSDTAPTGTERTDTDASAPV
GEEPVRTRTPLDELFGGPLRRPAGRRIGPAEPAPAAAEPVPAAPVSTPVTPPAPAPTAVP
AAREPGLPAGPDVIWGTGRSTEQVLALVREARRDHPDHPAVVVRASADTLVALASEHDAY
TTMDAAAMSAAVGPVPEPRGRVAVLCASTGDTPIAAEAAFVARVSGTEVVRVDDVGGSRI
RPLLADRSLLTDVDCLVVVAGLDAALASVVSGLTEVPVVAVPTSTGAGASFGGFGALLTM
LNSAAPGVVVSNIDNGWSAGVFAARIARRTAR
>A0A0M7M4S5|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MEASRLDSLAASAEYEARITARVMDRLFTEMVSVANMVARQGQVIQLAVRYRTDPPGAAD
LSREQRAALFTRDPLVRRVGDFMNELASDLRYARIYMNNMSDDTVTASSWAEPDSIVGMI
YSGRAYLEDALRDGYGSYFGIARLNKSPSYFVASRIEDSNDMPQGSVTVKFDAPDVALYL
AGRHIALVVNRQGRVTTASSEPFMLRNVAALLPADSVLPSDGDEDLGEPLDIRAIPGSIQ
SGRWLIDGRPYLARRQALANGQYHLITLASLESLAPMRKRHIWATGLVAMVGLVLILLSS
HVVAQMVRRRQDERHAANHDALTGLPNRRAIMAELERYFSEANRTQRSVQVAFIDLDGFK
TINDTYGHDIGDKFLIEVGRRLSAGLRSGEVLGRWGGDEFVVVGLGARSGPTADAVVETM
RTRLAPLLSGIYTLDDCSFHYAGASFGIVNADPSASALQAVLREADQLMYADKQARREMQ
IA
>A0A0M9IJT7|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MRINLRGLVLALTVCSALAATANALYASYRVQREQLIANTLESNRVYAAKLAESAGTFLD
SALQQLEYSARHVAWRFDAPEVLNAEVARLREQTDSFNTVAIIRADGVMVAASQAIRSFQ
GTRVDNAASRMALQTRKPLISKPYVSVAGNLLINVSYPIHSEGGIYLGYVSGTIYLRNEG
ALHNLLGKHPYQDGSYLYVVDNEGRLIYHAENDRVGEDVTSNPAVAAVMRGEDGAQRLIN
TRGVDMLAGYAHVSRSGWGVIAQRPALATLEPLHDLIWALIRYAAPFALLFLLAIWWCAR
KISQPLSQLATNVEHHDMAVAMQRVRSVKAWYFEAQRLKRAVIRSYSSLQDKIGKLNQAS
ITDPLTGLRNRRGTRQAVDALQAADTPFAVIALDIDHFKRVNDTYGHTVGDEAIQGMAQL
MRDCSRPTDILCRNGGEEFLILLPGAGPREATGMAERLRKTTEMRRASGSPEITVSAGVA
HWTAGSADVDLVFQAADAALYAAKQQGRNRVVTHAG
>A0A8J7VRV3|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MPTLAGRRRLRACLAVAALACAVAAGGVAAQSFPLRGYGTADGLRSLSASCLAEDADGVL
WVCTYSGLYRHDGDRFERIDAASGLRDAVILDVAPDPAGGLWIGGAADLYRWTGERAERV
AGVDGRGLAADAGASIAALADGAVVLSGERALRVVADGAGGWRTGPLFDAATEAATPALR
SLGAVYADGGALWFGCGEGICRRAEDGAIATFGPAQGVAADTWTDFLRDRGGRLWARSPL
HVAVLEPGAAAFAERPLPVALTTTTSNLDIVEDAAGRILTRTDSGLARWADGRWQVFDAR
NGLPDGAATALASGRNGQLWMAYPGHGVLRWLGYGRIENWDATVGLTGTPTWSILRDADG
RMLIGNNTGGGRIDPAAGRVVDWQLGGDTPARTVVGLTTGPRQALWVTLFRGQLLRRDAR
GTALVATLPHRIKRAFFDRDGRLWLCTLRGVYRIDDPLRDGTPRRVEDVPEVGFGDGMQD
AAGRVWLAGKPGLFRYADGRWTRIRVSGDVPSQRFDKLSVGSDDVLWVSVDNAGLFRGRV
DGDALRLEAVDDPLLAQSLPYFIRHDVRGRLWVGGSMGVDVHADGRWAHLGQAGGLVSDD
VSEGAFFADADGSVWIGTSLGVTHVLEPEALFAGAPLEVRIARAERGGQPLDDGAVLPWG
RQAVRLTLSTPGVVGSDLLRFRYRLRGRQDDWIETGARTLDFPVLESGQQVIEVQAIDLG
RRLRSGVTHFAFRIAPPWWRSPPALAAWSALGLLLLGGLWRWRVRRIRTRERELEALVAA
RTRELEDDKRALEQARAALQVQATHDSLTGLRNRAGILAALEQECARARAGGQPLAVALI
DLDHFKRINDTHGHLAGDAVLVQIAARLSARMRGSDTVGRYGGEELLVVLPGLVAPAGGR
LQALHEAVCGSPMEIEGESLRVTCSIGVAWLRAGDAPTALLRRADAALYRAKHAGRDRVV
AETAAD
>A0A7H9K3S8|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSLSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A5P9CKB0|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MVATSETVIRRLYQITNDYQKGFDIQITQLIMLGLERFNLDIGILSRVENDVYTVLHCVT
PEGMGLNPGDTFDYNATYCQITCSSFGPVAIENMGKDDRYAKHPAYEAFGLESYIGVPIF
IDDEVVGTLNFSSAIPYERSFAEVDIDALKLMASWIEVELIRRKQEERLKELNVKLEYQA
FNDALTGVANRRCMFKTIHSDIERMLLAEGKGSIAVLDIDHFKQVNDKYGHQVGDDVLKK
TAQALKSRLTDMDFIARFGGEEFVVWLPERSVDEREQIFSKLHQSVSEVVLDRGPITISI
GVCHFDFAQKKNLECKRTVLEYLIDRADSALYEAKKQGRDRIITVSS
>A0A7W4KI35|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3F3S800|diguanylate cyclase|EC 2.7.7.65|Tissierella praeacuta|TrEMBL
MKKGIHKLTAKIDNLERVRKLYIFLLIFSIVFLLAIINYFYISTFKDVKILYAQYIKERI
INIKKDFLKDSVNNMINNIEQTQAEIIETNKKRVDRATKVISEYHQLKQGDFLKKTIDYF
EIGTTKESFSILILNRDLDEVLYQNNIDHRIDIGGIHSYIENLKKDFIAYNEDNYGGYYI
LYGVTKDYIKDATTESIKKRIHKDSFENDAYIWINEVINYDGGDNYAIRRIHPNLKDTEG
IYLSTKMQDINGNHPYLTELNGIKENGEVYFTYFFKKKTCDEVAEKLTYAKLYKDYNWII
AMGIYFDDIQPYIDEISKDGDKAISKITTLIIILSLVLIFIGILIVLILEHWYYKNSNKE
LREELNIDELTKAFNRRAATKKLEEIFYLFRRYNYVYTIIFFDIDDFKQINDNYGHDVGD
IVLTNIVEIINKSTRRTDFLYRWGGEEFLLICEGLKEEHLESFTDKILKDIESFEYESEG
KKYHVTISIGASYFTEDDENFLSAIKRADMALYKSKKSGKNRATLDI
>A0A645CWT8|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MGDINCFKSYNDTLGHNAGDSVLVKVAGVLDKHMGRSGIVCRYGGDEFVVLLSNHSEEAV
IGQIRSVQDELMKEEIEMAFGYVFVSDPKQDLGLMIRQADVNMYVNKERMKHKNQ
>A0A822PUY1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHT
>A0A822PDM6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSG
TDITEERRTQERLRILANTDSITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKV
NDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTR
LRLPFRIGLIEVYTSCSVGISLSPEHGSDSATIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIENHLAWRSAQSGSTSTLAVT
>A0A5Y7A8L2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis str. CFSAN000515|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>K2FNY2|diguanylate cyclase|EC 2.7.7.65|uncultured bacterium|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIRDHSLILVEEFYKNMLLEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQEIMDCTDKNNMLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYIAHQSLNPAAQPLSV
>A0A0A8UQX6|diguanylate cyclase|EC 2.7.7.65|Legionella hackeliae|TrEMBL
MNLNEEKTLKGWAALVNALQVGVIITDNESVIRYINVRAAEIFQRNCQELIGSPFGFTLS
KNEDTEIEIIHPDQSVTIAEIHINQGFWLDRKSWIITLQDITERKHKESELEVAARVFSS
SCEGIIITDIDGRMIDVNTGFEHTFGYKKEEAIGKNVSLIKSGMQPPEFYQHMFSCLKKN
GSWQGELWDKRKDGKLVPIVLTISSIKNVNNETVFYVGLLHDISIIKKQEQELRYLAHFD
PLTNLYNINYITAELEISIKHYKTSGTPFSLAYVDIDRFQDINKQFDTHIGDIVLKKFGK
NMKRFIGEQGLVARVSGNTFVILVNQYHAEKSAHIFFEKLMKTINKKIRIKKNDIYISCS
LGYVIYPLEENTSSGQVLRQAEAAMIESKIKGGSQATEYNIDEVIEQKYRYHIISEVTHG
INANEFAVFYQPKVNMKTGEILGAEALIRWHHPQKGLCYPEYFLPYVENNEVMNRLSSLI
FDEVFNQLEEWLKQGIDLRISINVSAHELQQENFFNEIKTKMEQYGNRLNRNIELELLES
AAVRDIKSVRKIISQFHEIDLRISLDDFGTGYSSLSYLRALQVDAIKIDQSFINEISSSP
KVIAIIDSILHMAKRFNQSVIAEGVDSLEKGILLLKLGCVEGQGYFIGKPMPVSEFQSWM
ESWKAPPEWQQQQSVYQENLDLIYAQSFIVWAVNTLSQAKKISHREMVSLESSLNSLAHY
VNSSFSPHSNTVKMELEELIDEFFQKCKSFNTARITQQNRESYLADLVNSSQLLQKKIDL
LNLKYEPNQNNLC
>A0A655QT49|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMEMHHFA
>A0A0H6BHK2|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTDQTRTSPLVNRLLKMISLCALGYLLIILAIIIPRGIQSVEQQKQELEEKLALSLSNSA
AIALYVNNYDIASEVMDALLLHQEINAVKLASVDGIVFERTTIPSTYKEQNYWSDANRYR
LDSPVDGNLIGYLMIHEDHQVIRQQAINQILDQIAVVLIQFLVTFIALIWIVRRLVGKPL
TDLSQALSEVRPDHDRKVAVAAEDHHNEIGLVAKSINEFIDASHQALLRERELRQQIERW
ESYYRTIAEQDTLTGLKNRLGCEKFVLRKQRASTTMVLLLIDLDGFKQVNDTLGHAAGDE
VLREIAKRFYALAQTHFSDFVVGRLGGDEFAIYIPLDEFVAESIERFAAQLIESSSEPIG
LGQQSAQVGCSIGISHMNSLHIDLEKLLLQADKAMYWVKYRGKHGYHIYRMGEEILPLPS
AKELKQDQFR
>A0A378YTU0|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MNAPNTDNYDLESEYEALLSFMYLSPVGIVRSDKSGAVDMMNPLAAQLLMPLVRGGSIEN
IFDSLASVAPELRNLVASFEAERGPVCENHRIFVTPAKDDAVVLACSIIKVSADVLMMVL
TDISRQVAAERRARQTESWLAGIYTSVNDFAYFTLDAQGCIDTWNPSIERLTGYEAADVI
GHMLSRFYADDEIVLHRSPEHMALTRDDGWHVEEFWCKTRSGRRYWGQLLVAVLREEDGE
ISGYSAVLRDITERKIHSDNLARLLTTDHLTGVTNRAHFFEIGESEVARSKRNGRTLSLV
MLDADHFKQINDNAGHQAGDEVLKRITDEARALLRRSDIVARLGGEEFILLLPSTTAQEA
MAVAERLRVAVEQAAIETAVGQLNATISLGVASLEDENQTLQDLLAAADHALYDAKQAGR
NCVRGFVVPTEDAANVVGESGNAVST
>A0A0H6J4Q1|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVYGLRFTHYTRLLEQRMRFCFPLMEQKIEVSSTSRMLIMTRKKFSWILVTLIIFGFFVT
SLVSYKVAHDTLEEQINKDSLPLTSDNIYSEIQQDLIRPIFISSLMAQDTFVREWTLAGE
QDPERIIRYLREIQRQYQTISSFYISDRTGHYYHYTGILKQVSESNPNDAWFYRVKNSAP
DKNFEVNIDIDTANSQQTVVFVNYKVFDFENRFLGVIGVGLSSDAVSALVEKYQKRYNRH
IYFINELGEVTLHGSHHPGFDQIQQREGLKTLATQILTSPSVGASYYADGQKVYLNSRWV
DEFQWYIIVEQKDEFNHDIWFKATLGNLAISAFVALGVLGLAQMSFRGYQKRLEDMAVRD
KLTGAYNRQVFEELVDDAISLANKESHPLSLAVIDLDHFKQVNDNYGHPAGDLVLQRVVA
LCQRHIAQVGTLCRWGGEEFVVLLPHMTQQEAYQRMESIRAEIAMHASQPQVTVSIGVVQ
YQQNESLLHLFNRADQAMYTAKSEGRNKVVGL
>A0A656AR59|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNLNNFSLRWLTTLNALAVVLGFLMFYLTFKYFWSHDREVAQVLQLQQAELQRVETLLSL
ERKAMGASLADYAAWDEMADFIAKPTLEFTQSNIGEHAFSSQFLDGVFIYDPEGNLVWGK
KYDAATGQSSSYEHLLPDFSRILQQATRLSVDEISTSVRYMVVEDEPYLAATARVCDSDG
KGCNKGFLIFIKKVRAQFANVVEQATGVDIEVLTCKNDAPLPQDEVDVSYIKQLDYSGNS
SVLFKINHHIKHPPFIRTEEILALLFFSLVMYLVNLWVVIALIKPITTASQVLQQFKTSG
GKMPDASTFISSEMKEFATTINRIVGQLEDSQQVLRWQSEHDPLTRISNRRHLEKQLKSY
LSDRPQAYLVLFLVDIDFFKRFNDSFGHLAGDEALCSVADVLQSVEFHGEKIVARFGGEE
FCVVLASDCAFDAEQYAQQMRSKIEQLAIANPVDALCQYLTVSIGGVYAISPKMESYLSL
FHQADMALYHAKEHGRDRYVVRNFV
>A0A1R3TCI5|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MLAFIDHYVKKACSTNRFETRRDVLSFALSITLCVTIAADVLNVVAHYSLDGLGWLPYDV
VPAATVGVIISTLVASSLTFSITYVVGLAIHHLTISRATFERLSRTDMLSGLLNRRAFLE
EAMRAPANSSLILFDIDKFKSINDQYGHDIGDQAIIAVATNLSEIFAHCKAVARIGGEEF
AVLVSALTPTERFALAQRCRELIAAQSFEAGSSRFHVTISGGVADQEDHPTFEALYTACD
KALYLAKASGRNRVVHSRDIQSLERPEAHKARVPVKRRSIQK
>A0A719WDL1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. 404ty|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A0W0U5G3|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MIPPDIPENEAGRLATLYKLKILDTEQEERFDRITRIACKLFEVPISVISFLEAERQWMK
STQGFDIKEAERKTSFCGHVILSDEIMVVEDATKDKRFHDNPFVLGKPHFRFYLGCPLKI
KGYNVGVICLIDNKPRARNEIDHNVIYDLAQMVEMDLEQLQVSITDELTGLSNRRGFLKL
ASYLFQKCQRGNQLFTLLFFDLDQFKSINDQFGHAEGDMVLKIFANCLLQNFRYNDVIAR
LGGDEFCVFCSGLNQKDVSGIIQRLKDSLKSAKTKDYTIQFSVGVIQYDPKQHRTLGDMM
ALADSEMYVSKRGNSSL
>A0A0H7RCQ8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPIMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFAHPLPIEIFEESYLE
EK
>A0A0I0JS54|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGMGIAQTKTLAKLANHAAKKWQRQTGGAPIKLSSML
>A0A8B4CMZ5|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVL
ARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDS
ATIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALENDQLVIHYQPKI
TWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVAKWRDKG
INLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQF
SQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQAL
NLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKRA
>A0A509JAX0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPESLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A5H6JJ89|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Napoli|TrEMBL
MNKEFSLTRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G7LEK7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRGGLRRQELG
>A0A5W2LXZ2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lattenkamp|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5I5V6V4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Napoli|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8F9IKD9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFRSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A735EUT4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7H4MKK9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MTNTAPMLLIDPSKDGRIVDANIAALRFYHYSDEEMRNKHTWQINTLGRDVIPIMNNIAN
MPGGHKPLNFTHILADGTLRHVQTYAGPVVLYNIRLMLCIIHDITEEVHLKKELEFSAAH
DPLTGLLNRREFYRLVEAPSFIAQGFCLLLIDIDHFKSINDIHGHQKGDEVLLVISRILE
TSVDREDKIYRWGGEEFLLFLPHSPIARALILAEGIRQAVSEYQTLSVTVSIGVAEHHDG
EAIDQLFSRVDKALYVAKNGGRNRVSRLPFENVELLHSRGGAA
>A0A632MZE5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>Q1Q6E7|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MKLLLKYMDRMPKIIIAASSSLLVVFLGIIDYASGSEISFSIFYLLPVLMATWFAKRRYG
VVISVFSAITWYLADINSGHAYSHYIIPVWNSIMRLGFFLIVTSSIDKVRNLLNKEKSMA
RNDFLTGVANRRFFYEIATKEIERIARFIHPLSLAYIDIDNFKQVNDTLGHSAGDKLLQV
VAGTIKENIRSIDTVSRLGGDEFALLMPETNAQSAITALNKLRHALLDMVHENNWPVTFS
IGLVTCSESCKLNELIKEADNLMYTIKASGKNRIENKVHSFNKTSA
>A0A419IQH3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Schwarzengrund|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5B0SV82|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>A0A7I7DMT2|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADHSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAAIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPNYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A0H0B8F6|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGATIGEIRLTARDSLIGHFIWMSFAVLTGCILFATVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQAYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASVEALLERADRNMYQVKNQRTKTTS
>A0A7Z8DMA1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A3T2V0N5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINSLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A7H4N177|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MSDFILARVSQTLANEHSLETLVRQLLEMLELVTRMESTYLTRIDFDAQRQHIMYAHNSS
EMQIPEGFSVPWNDSLCKRALDDRCIFSNDVAERWRSCLAAQDLGIATFFSIPVRLTDGS
LFGTLCATSRARQPYNIEGEQVMNLFANLISHYVEKETLVQQLRAANVALEMHSYTDELT
GLPNRRSLFKHLAAQFSQAREQQRSVLLIFIDLDDFKAINDRFGHPCGDSFLIQIGERLA
ARVRSGDIVGRLGGDEFLIVGPGPDSADQQEYIAALRQALAGIYFLGEHRINYPGASFGV
IEADPWQIDVELALRAADEAMYQDKQSRRQGRFFHID
>A0A0T9UU77|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVGSVLYTENASLWLWIALAINGLIWP
HIAFLLALRSEQPFEQEIINMKIDSALGGVWVAIMSFNALPSIVILSMMSMNNIASGGKN
VFYKGLALQIACSLLTAWIFNLPFRPETSPIQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQEKLAGLAF
AQAPPLQLKVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A0D6HE05|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MIAPVHLLSIAVLTGVLSLCVLGSLARSGMAGIRETIRANLLTLLAFFLFGLQATEAPRW
ASILLPNMLISLALCAYYTGVRRLLGQRVPRRLMGVACAAAWLALVGYTYLDSQVAPRIV
AMSTLQMGFMFAVAVAVARGVPANRSRYSYYFVWSVAMISGLTCALRSILFATGVAQADF
LLQPTTWNIVFMTLGVLAMPCLTLGTIMIIHDRMLADREHEASTDFLTGLMSRKAWWLQA
ERYCAQALRTRRPLSLLLLDIDHFKRINDTHGHAAGDAVLRHFGLLATATLRTGDHLGRV
GGEEFSVLFADMRSDAVLEVAQRLLDSVRRTPCAHGGSTIAYTFSAGVVDWLPGENLQAF
FERADRMLYAAKQAGRNRVLGPGMHQAERAPLPVAA
>A0A484RN51|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSAPTELLATTWRRAQARHEPGTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIAFNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLGDAPVAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENAFVYEIAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLADTPAQAAIPVLKTVREQCAAIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQKASHLSVLSIDIDHFKGINDQYGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQAMAIGEKLRRRAELERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADTALYGAKRAGRNRVLANSAL
>A0A735MZJ2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Panama|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7W6VD89|diguanylate cyclase|EC 2.7.7.65|Rhizobium etli|TrEMBL
MTARILVVDDIPANVKLLEARLLADYFDVMTAADGHEALAICERNQVDLILLDIMMPGID
GFEVCERLKASQKTAHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRADTAHTMGMGDLMRAGEGRADEAGQVLLVDSRANSQERIVRALKPVAD
VLALSDPQAALFEAAENVFDLVIVNANFDDYDPLRLCSQLRSLERTRFLPILIITEQGAD
EMVVRALDLGVNDYIIRPVDPNELVARSLTQIRRKRYNDRLRASVKQTIELAVTDPLTGL
YNRRYLDNHLSVLFNRSMARGRPLSVLITDIDRFKQVNDTYGHDGGDEVLREFANRVRST
IRGADLACRYGGEEFVVAMPDTSPEVAAAVAERLRAAVESAPFMLKHSGEALNVTASFGI
ASRIGSVLTPDQLMKQADLALYEAKNTGRNRVVAAAA
>A0A5I9DH47|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7G6K912|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSCADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A0B9XJ37|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
METLDSSIFDLTPIPMWIEDFSEVKQLFDLWRNQGVENLYEFLSQNENLVVECAHKIKII
KVNQKVLDLFEAKSQEELCANLNLLFKKEMFEAHIHELEALWNGKTHFSSTTINYTLSGK
RIDVQLRGAILPGSETTFDRILITTEDITPYQNALRQEEKNRRLAESMFIYSPTSLWVED
FSRIKNRIDQLRLLGIEDFRTFLDVHPEFVRQCIEDILILDVNQSTLDLFKAPDKTTLLK
NTHKIFAEEMVETFREQLIELWQGNIHHKREAVNYALDGQIRNVLLQFTVFPGYEETWGL
VQVALTDITARKKAENYLEYLGQHDVLTKLYNRAFFTEELNRLNRSIIRPVSSIFLDMNG
LKETNDQLGHDIGDGLLRRVGNILNQAIMNTAYTASRIGGDEFVILMPGADEANVLMMLQ
TIQELFNIDNQYYSSHPISIAIGHATTKENEQVEDMLKRADHHMYQKKKSYYQEILLP
>A0A3V8T6K2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3Y2K3B5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5F1HVP8|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E1130|TrEMBL
MIKKTTEIDAILLDLNKAIDAHYQWLVSMFHSVVARDTSQPEITDNHSYELCQFGRWLDH
HGPLDSDELPYVRIIDSTHQHMHNCGRELMLAIVENRWQEVHFDEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFEHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLAGWTRDYDTVYRYGGEEFIIIIKAQNDAEACRAGVRICQLVDNHAIAH
PGGHIPITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQSVIARV
>A0A3Y7FCP7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0C7KG93|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLIIIAVAAGCALVSPPVGTRHEILNNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHAL
AQAILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
SAGAAG
>A0A7D6V497|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGMWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7V8PBK5|diguanylate cyclase|EC 2.7.7.65|Pectobacterium versatile|TrEMBL
MNEQLNVNEQRDNGESDYNQVITSEWTKLIATTSQKSFNLLRTLAAQKASDFADEFYTYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAKVAEDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIITETDDYIRSHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTSLSIAMIDIDHFKSVNDTYGHAA
GDSILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAYTIIERLRKKIQDHPIHL
QNGGSVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A0L7T6N0|diguanylate cyclase|EC 2.7.7.65|Erwinia iniecta|TrEMBL
MGSEKDPRIIVHLCFLTVFLFSTFLTWREALVLKNTYEVNQQIRLTTVAVTLDRQFQFSL
DALGFYRSMLSYALTSPIDSDNSRQAARLFDQQRNNPVWRLNLNTQRSLPLNGLSDSWIK
HYPVLNRDNPQRLRDELSAALEFSFILQFSDPERDFQTRTWYLSRGGFYVSSTPPLNDND
VLESYRGMIQRDYFTFMHPDNNPQRQHYWTPVYNGLLNEGATVTVTVPVDSGHYWYGVLA
MDFSREAIHRQLQRALQQKHQGVVLLYDHQLNVLASSDMQLGISGHALSASEKQQLQAAL
QQGVRGELRFGTRFVTWDKLRGFNGVIVNIQTLHEGLKGDAGRIVLVLILMWLVFSLILL
GSHYAITRLITQMMRLQNKLEWRANYDGLTRLYNRAAFFDLCEHSAAQCQRSGRPLALIQ
MDIDFFKSVNDNYGHHAGDLALSHAACIITQSLRKMDIAGRVGGEEFCLLLPETHLQDAV
AIAERLRQKLAQKELLVSSDKTLKLTASFGVASSEEQGDYQPASLQSLADGRLYKAKQSG
RNRVCWQS
>A0A2K9E820|diguanylate cyclase|EC 2.7.7.65|Acetivibrio saccincola|TrEMBL
MDIINDSVIEKKLKSIEPKKGYVFVRWGLLLLIIPIFLIVSDKPFLYVRFWFVFAFASVY
NVVFSILYLKSKLAGKNFGFIFYADILLVSIFSYFLGGLQSDIYVLLFFIIAYYGTSRDV
SSITKISIFTIITYCVLSLLSEGGNLAGFNFLKLAIRGMFIIFTAYGISSIIIQVKIYDE
MHKREFKRARTDKLTGLANRHYFDQKLEEEALYAEYSGKPLNVLMFDIDNFKVYNDSYGH
IEGDKLLSLFGNIILQSIRKTDIPVRYGGEEFIILIRDLDLEMAKNVGDRIRNQLEKENM
SLENKKDSVKVTVSCGIAQFPKHSDNIKKVVEYADKALYHAKRTGKNKVVCYDEVLQLEH
ELEVNKAKTS
>A0A431SJQ6|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MSDIILARVSETLSTEQSLDSLVRQLLEMLEIVTDMESTYLTKIDINARLQHILYARNSK
QMQIPEGFSVPWDETLCKRAMDSDTLFSNEVPDRWPECEAAKALGITTYMSVPVHLADGS
LYGTLCAASTAQKQFSERGEQVIRLFAGLIGQYIQKESLVLQLREANAALIAHSYTDALT
GLPNRRAIFENLTTLFSLARHLNRNVMIAFIDLDDFKRINDQYGHEAGDRFLVQVGNRLT
HQQTQDEIIGRLGGDEFLVASLSHSDDGDASTEVNAIKTRLNGRIAGEYGLGNVTILYPG
ASYGVVIVDPHCTDEDSALRTADLAMYQDKKGKNKTGFVALD
>A0A081IHR9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPEHVHHIVKRLILYICICLLAGIGISGMTAFFHTSFSSTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVSFGFACSALLMLGTLSSYPDWLTCNPAPVVNQNDAVIYYFF
RNIMMAVLFMSSIILYYFRQRIMHSWKAHVLTFTACILFTLTIIVLSWLYSSHSPWLSVN
FIDDLSHTFTPLWQSIIGWLLMAVWFITLILLISLSKLRNIFWFSGAFFCSAYLFTLFQL
LSTAGELDQTWYQARFFETLCTLFLILVLLVDVFILYRESNHKYVHSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNAQHPLSVLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSR
VDDAAARIGGEEFALLLVNTGEKEAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNS
VTAEACVQRADEAMYEAKNNGRNQVIVWHRQGG
>A0A377W1S7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLKFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A1U0PYG3|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. massiliense|TrEMBL
MQNPPYVETGYQYDLVTNALRDTGQLGRLKTGIGLLCFVIVFLQGVTQFYPLGPHGTWPR
VVHGITAASAVVAGLCWLSFSWPGRRAMAAFVVWADVALAVGAALLSDPTARICAIVYLG
PVGLLPTFFLSRRALVAHCAFATSLLGAVLAVNVLSGEARMFEQFFYAAPVISAIVLVPA
VIQLVLEGGRDSILSAALAADRDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDVDG
LKELNDTHGHGAGDMTLKAVADMLRARTRVGEIAARFGGDEFLVVAFPGRGEDIESTIRR
VSAPRAGIDYWTVSVGAAWQSRTGSKVDLESLVQQADHSLYEAKKTRGMLDPQR
>A0A853T368|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MAGRQRRASWRKAHWLLVLACLLPPAAHAQVSDLEQYLAAVRDDGRYVPARALQRLQEVE
TQARSAPLPVRAEFLTQLSNARMRLGQNDIAMQLAEELIAYARMNKSDVALAKGILNKAY
ITFARNERRASHLLAFEAEKIANGTDDLPVRVQATISAGQSWAEEGNFPFALAKLQAAVD
LARQSKSPSSLAAALNALTLLYTQMREYDKGFEVLDELLAVSARLASPGRMAQAKNTEYG
LALDAQQPQRGQRALLAALALERQLGARGMVAVTLVNLSDSYLKEGDYARALRYANEAIT
AADLVNDEQVEATARLNIGQALIGQGRLQEGKQSVATGLAYYERTANQPEMQAVLLEYGM
ALEKAGDLRGAVTAYHRERGISNQLFEKQRQKAVYELQEKYEAEKKQRQIELLSRENQLK
STEIDNRRLQQRVWWLLALVLAMASTIVGLLYRKVRHANVQLKVKNQELKRQSSRDPLTA
LYNRRHFQEFMRSHAGKPQPSYAGDDVVGALFLLDVDHFKHINDAYGHAAGDLVLTTIAE
TLHDVLRETDMIVRWGGEEFLAFLPAVARDGLDEIARRILNGMAAQRIDYQGQTIEVHVS
VGFAPYPLAPLGRPLTWERSVNLIDMALYLAKAHGRNRAYGLRGFHQVERTTLEAVEQDL
ERAWRDGFVDLSVVLGGMDEADRTETAGTQTLTPGGQAGDGVAAAAVT
>A0A0P7MMF1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A377ZES6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A0J3VXF6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNNTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAATHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A844PV35|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQIFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A426PCC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNRSYFAIN
>A0A8F6I8Q1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAMMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
AEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A0L7ADC8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNAKNLSNKTLRVRFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2U9KTK5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
EPRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A765T5R2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MLHEIKTEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRSQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A3V4SPV0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Altona|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F6JXB1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVMLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A826XFE0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENRWQDAHFDEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLATWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQLVDNHAIAH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVITRV
>A0A238DS93|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MASVLSLSIVPSPAGLPQISPDPVLDHVLRTGQLHAVFQPLMDLRNRTFHGFEALVRGPA
DSHLERPDQLFEAARQCGRLAELDRLCAQIGIETFASQGLHGHLFLNVTEALFDSGWFAE
KTTLQWLQALGLAPSRLVLELLESDALAQDSHAIEQAQFLRELGYGLALDDLGQGFGRFA
LWKRLRPRYLKIDRSFTANLGDDPFKAAFVQSMLLLAEASQSIVVAEGVESERDLLTLRE
LGVPMAQGYFIARPHAYPPSEPATMTRRVLDSPQPTLHALASRGSIEQSVLGLARRVEPV
RPETKLEVILQILEQDRDLMSVPVVDVDWTPLGIINRYVLADRLFRPHVRDLFGNKPCSL
VMSSDVLRLDAKSSLQQASSLIAESSYRHATEGVLVTDQGQYRGILLVGDLLRLVTEFQV
QAARYANPLTLLPGNVPINDCIDRWLREGQRFAAAYCDIDNFKPFNDKFGYRMGDEIILL
VAELLKTHLPQAVSFVGHVGGDDFIALSQSPAWEAELQQVLRGFEAAMAGYFEAGVLHDG
GFWADNRRGDAVFFPIPTLSIGAVCVDARAFESHRELSNVLADIKKAAKRLPGNQLFVDR
RHHA
>A0A827E560|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDDPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNDVTNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFFGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTHNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKLNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPKTCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A377B253|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIGRFGGDEFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMS
HYREWLKSADLALYKAKKAGRNRTEVAA
>A0A0K4H6N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTTHNFNTLDLLTSPVWIVSPFEEQLIYANSAARQLMQELTFSQLRTGLYSISSQNELPK
YLADLHNQLDIVEILTVQRNGEETALSCRLTLKEMSGAGEVIIFEGMETPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRNVMPVMHEISRLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDRLMLCIVHDIT
EQKRLEEQLEHAAHHDALTGLLNRRQFYHITEQGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHQKGDEVLCTLAHTLKNCARKSDLVFRWGGEEFVLLLPRTPLDTALSLAEAIRLSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2X1ML07|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNDHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWGGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2K3TSR8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSNNYWYGVLGMNIPVRTMQQFLQNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTHLYNRGALFEKARQLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRALDVAGRVGGEE
FCVILPGANLAQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGNYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3V2JDN2|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2X3K2G0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELAD
HNMYQAKHQRAEKLVR
>A0A6G3HW91|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0A0H6D5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A853T205|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MNKVLALRLLDAAEDAAVIIDTASRIQYANDAMYALSGYAQGSLAGQQIEALLPDAVREQ
HGAQIGAYLAGEKKSRVLGHKRHFAIRHHDGSMLPIVLKAMDLGKLGDENYMGAFFIDQR
RERALEQQNAARWQQLQRIALSDPLTHLPNRRAFEVEAVRAAARARRAHTPLAIGIADID
FFKLVNDQHGHAAGDAVLQTIAAVFQFQARASDVVARVGGEEFGFLFPHTNMSMACQVAE
RIRRAVEETRFEFGKLSIPVTISIGMAPLPDNGDWKAAFMQADAALYQAKNNGRNRVEQA
>A0A370V1M0|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTLVSHPP
PGWWWLVLVGWAFVWPHLAWQLASRAIDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSIA
MLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPIIVIYP
LLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAENA
ITAMLRVHDGLNTLRLPSTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAKKAGRN
RTEVAA
>A0A377ZXU3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A0K4IYS8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVLPNTTFRLFKEGHLLRNSFAIFVLTTLFYFIGAKLRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAICYVAMLAYDAMTTEWGLVSLVINLSNMMFIATVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
VIPGVMPRFKAERLMPAMALIVSVSASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
ITGAVEIVLVANSVIDIAVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVS
LRADFDFLTQVYSRSGLYEALKNPSLQQTQHLTVMLLDIDYFKNINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFNWQQKTLYL
TVSIGVGSGCASFLTLTDDFNKLMVEADECLYRSKKDGRNRTSTMRYDEEVV
>A0A5I6Q4R9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMPEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A738ATC8|diguanylate cyclase|EC 2.7.7.65|Salmonella abortus-equi|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3U7JR23|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Give|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2E2KY48|diguanylate cyclase|EC 2.7.7.65|Rhodobacteraceae bacterium|TrEMBL
MTRLAEMPQALSVLCPMHLILNADGVIMQVGPTLQKLRPGLAMTGLRFLDLFDLIRPRSA
AGVEDLFDSARTKLRLQFRDAPRTGFKGILLPLPEGGGIVNLSFGFSVLDAVRDYALTGA
DFPATDLTIEMLYLVEAKSAAMEASRSLNTRLQAAKIAAEEQAFTDTLTGLKNRRALNHV
MTRLLIAQRPFAVMQLDLDFFKTINDTYGHAAGDHVLQVVARNMVSETRETDTVARIGGD
EFVLIFDRLQDRTRLESIAERLISSITAPIPFETRLCQVSASIGSALYDGVSDSDTAALL
AEADAALYAAKRAGRGRHFTFDAERRAAVPG
>A0A2T8WV49|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Gaminara|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2K4AJX4|diguanylate cyclase|EC 2.7.7.65|Staphylococcus schweitzeri|TrEMBL
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYL
IHLTFVPLLFLGRFTNMVYTLSATLIVSIVEVVVFNNSIMYGVTLIVIAAVTSAIGPFLK
QNDVLSLLILNVVTIIILFGVALVSPLYNLSEVIILIPISLIITLASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRYLNEISQKAEKEHQSIALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTDEDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>A0A744GM53|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQVKHRRAERSLN
>A0A5Z3YC73|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRLTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4U8J048|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Chester|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAVEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>Q8Z4I6|diguanylate cyclase|EC 2.7.7.65|Salmonella typhi|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A744MYN8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTPETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A625ZFP9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSTEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A485B246|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTAQSWRAHYEKKYQYSLRLFLVLNLISAFLSLASPLFTVVSFTLPCTLIFACSAGLLLW
HWKFAQRRINISFISLIFGLLWAWHVCEKSSMMPPPHFNFLVIALLSVLFIGAIAFSNNI
IAFTLHSFPTFIACLILAEGEQWLRMLYCFMLPIAGITMQNLIQKRSDTFTQGLMDKLLK
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGNSHHVLLLDIDHFKAYNDHYGHMMG
DQALIQVSAAIRNAVRSRDIVARFGGEEFMVLLTNSTAETAQQAAERIRQRVYDLKIAHM
FNESVATNVTISIGLTPLVDADIDGALKRADSALYEAKKLGRNIILAS
>A0A5Y5ICG2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3V5W0X9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Ohio|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A605YGW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379JZ48|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MFYLDHLPGPVLVTDCNGRIKHSNCDFKRLAGAGAAEGMDQFFPPASRIFLQTHAWPLLL
RNGEFSELYLQLQSENGQAIPVMANARISEVDGTPEVIWLFFVAKDRQRFEAELLKAREQ
AQESAAQLAKANLALQSAYAQLANYAVEIQSEAEQLAQLSHTDPLTALSNRRALSVHVEQ
WLGSVSDLACSSLLLIDIDHFKQINDRFGHAEGDRVLVDMAQRLLASVRSGDSVVRYGGE
EFAIWLPHADLAEASDIAERVHDQVKALEIANESVTVSIGIASLKPCERYLERLLAAADK
ALYIAKAQGRNRSIRHE
>A0A7W3B4Y5|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RHBSTW-00215|TrEMBL
MKLLRCVDFDKVDSHIMELSKATESHFRWLVHIIECIARDEFISADIFNKESYKYCSFGR
WLKSFFTSEHQDYNYLQSINDSHIKLHQTCRTLLLTIKQERNRDTLLLNFENSLLEFIGK
LDKYKEHLLKLRSSYDFLTGLPSRKLLDEYFTGSRYKKNDEITYLLLLDIDYFKMINDSY
GHLAGDLVLKYFAKHLRSLIRNTDMVFRYGGEEFIILLNVISDKKACYAAERIRKKIINL
DFHFKDEIINITFTAGLVKVLPMEALEESIRKADQALYEGKSSGRNCTMFLSGNGRISKI
R
>K8CQV5|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii 696|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIAGFKAERDKPEWTLPTGRDLAPEIQ
GVSDAFIGQSTLLERDDALLYSELNATLALGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTVSIPLDDK
GRWFGVLAMDFPIGAMRDFLKNALNDDDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNAGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTADGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A853SN29|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MLMTTLMCGAMSIVMFSVYRSFRREVHGLGHWAAGLLLLVCASLLFGTREVLPPALSVIA
ANAALVAGIGLSMLGTETFFGLAPSRRAYLLILALAIAGNSWWLLVHPDFSARVAVFSLL
VFLFYARQAQLVWRHGERHFSSFFFGALMLTQAIVVLARGVSALLHGGASVNLTVAGTPA
GIYLAVANFMALLLTVGFMTVATRRLQQILERRSTHDPLTQVLNRRGFGDAYAREMGNLR
RRRLPLTLLSIDLDYFKSINDRYGHAVGDQVLAHVATVIGGALRESDCVARYGGEEFVVL
MPDMPAQSALGVAERIRTLLRESRHAGLPSCTVSIGVACQASVVEGLEQLLSRADAALYL
AKERGRDRIELDTAALTVDRTMSAAGIGTGR
>G4T2F6|diguanylate cyclase|EC 2.7.7.65|Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z)|TrEMBL
MNYRTSVNSTLSRIALTALLFYFAGQLALPLSLPPSYATAIWPPAGIGFAATLLWGNKVL
PAIFLAELAIHYEVYDFMTLWQSPRQLLIFLSSPVNSVLRAWTGAVLVKKIVGYPNPLIS
AKEIMLFFLLSGPVATLIPALLSVYALVETGVIVESDFGFGFLTWWLGDCIGIVVFTPLF
LTIFEPSLQSRTKRWLPLCTALIVGLALVAISYLLAHQREGLRLQEIIENKAETIQYALE
DNYKAHANTLSLYHSLIGSNDTIDYQSLQIFSDWVFNTYPGVPYIEWLEASKASQDKTAW
TIKYSAKKYFDDFHPISEKRHQEIVFALEPQATTDRSSKILAFGNSSRQFFIYTPFFETE
QTLKGYIIEAFDIERFIDDALVRKSIEYIDIRLFQKTSDGEQQWLFPLEPKRAIPDPFAI
TTLKPLNIGGQSWFIQVSPDLGFLGNYYSWPVWGILAGGMLLTSLMGIGFLIVTGQTELI
LVEVEKRTHDLNQSNRKLRLSEEQLRLAATAFETQEGIMITDKKGRILRVNNAHTEITGY
SSEEVIGKIPSVLSSIHHNRDCFDEFWKQLASQGQYEGEIWNRRKNGEVYPEWQTVTAVK
NEAGEITHFVSIFSDITEKKENESRIHNLAFYDPLTNLPNRRLLINRLEKEIAIAKRHGH
FGAVIFMDLDHFKFLNDSLGHHVGDELLIQVANRLQSVVRDEDTAARLGGDEFIVLINCN
AKNLSEAADHALTVAEKINAKINEPFLLNAFQHQLSPSMGITLFPDNDDNPDRILQQADT
AMYRSKASGRNSISFFHPSMQEAADLRIKMENELREAIDQGHFVLNYQAQFGAKNEIIGA
EALIRWQHPQKGLIPPVEFIKIAEESRLILQLGRWVIMEACLQIQSWQQNGLIVPRIAIN
VSSNQFRQSNFVDQIEHSLKVSGITPDCLEIELTEHVVIDNIEDTIEKMKALKALGLSIS
IDDFGTGYSSLAYLKQLPLNQLKIDKSFVRDISTDPNDAIIVETMIDMAKHLGLTMIAEG
VETAEQLAFLKSKGCTGFQGYYFSHPVTADQFAELLSEQSPQVI
>A0A7V7PYX0|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii|TrEMBL
MPSGIAPDGNAYADYVVMIKKKNKQELAATPHPLLRLVSLGLLTYIFTLFSLELTLFDTL
LAPLWFPTSIMMVAFFRHALRLWVPIALVCGAGTVLATLTLFPPGHLELSYTAINIVEAL
VGAILLRKLLPWYNPLKNLNNWLRLAFASAVVPPLVGGLLLAAISEGHVTLRLALVWILS
ETIGALALVPLGLLFKARYLLRHRSPRLLAESLATLCVTLLCSWLALHYMPWPFTFVIVL
LMWSAIRLPRLEAFTVFLATVMMVSFVIATNPALLDLPHQGMVVNAPWLPFLMILLPANV
MTMVMYASREERKLITESETRFRNAMEYSAIGMALVSTEGGFLQVNKALCNFLGYTPEQL
AHMSFQQLTYPEDLHADMEQVEKLLNGETNNYSLEKRYYTRAGDVVWALLAVSIVRQRDG
SPLYFIAQVEDITELKRTEWVNKRLMERITLANEAGGIGIWEWELGTDVLAWDQRMFELY
EVPPHTRPTYQLWKSRLLKEDVAHAEATIQEALRARMPFKLEFRIQVKNGVRHIRALANR
VLNKQGEVERLLGVNMDMTEVKQLNEALFQEKERLHITLDSIGEAVICTDVDMNVTFMNP
VAEKMSGWRQEEAIGQSILTILRITFGDNGPLLDDIHSGEATHAGTGIEQDVVLHCRSGG
NYDIHYTITPLSTLEGENIGSVLVIHDVTESRKMLRQLSYSASHDALTHLANRVSFETHL
KRLLQSVSDTHQRHALVYIDLDRFKAVNDSAGHAAGDALLRELASLMLGMLRTTDVLARL
GGDEFGLLLPDCSLENARTICERIVAAINEYPFVWESRLHRIGASAGITIIDASNNQAQD
VMSQADIACYTSKNAGRGVVTVYEPHQQQLHSGRGTLTAQEQQRMINEHHHVLMVRPVAS
PRVPESASFWLLSLRLWTSEGEMIEEHSFRAGLNDPELMQALDTRMMTDFFRDHAASVAQ
KGVGVALTLSGATLLNAQRLDALLAQLAASPLPPRLLHLVIDSDVLMQDTTQARRQLARL
REAGCRVVLSHIGRELEVFEHLSASCADYIMVASDLVADAHASLMDEMLLTIVMGNARRL
GLQTIAGPADQQSLLETLANVGIDLVFGETVAQTQALSARLATSYFAIH
>A0A8F9NQI4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLTLDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>A0A485H3F6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MRTDKPPLKQRALQKLLLRRFGMAAGTYLFGLVLLWLAVLSGFYRAAPTTAALSTTLVVA
CQLAFLWLFASGRNLRYADPSLTEPQVLVAIVWLTYFLYHVDSLRGTFMVFYVLALLFGI
FQLPPRVFARCAALAFIAFSGIHLVEVLQRRLELPGRAALQVLVLFIVLVWLSLFASYVQ
AMRQRMRQRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFMRMAGRALEDLLPNR
QHGLALIDLDHFKRINDRHGHAAGDRVLQTFAAVARSCLRDGDILARYGGEEFVLLLPHA
DAEQLESCCERLRLAFEQAEPVGVAVEVLSLSVGMTLLYADDDLDEALQRADQALYRAKR
GGRNRCDATWEVTSA
>T0PP58|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MNDIAAVAGQLARLRESLQQKQLELDGIVTFSDAERARSIQFIGKLMQACRGHDRELDNK
LAKLKQKLDGNPPLSSLDADLAVIEKLLQQHGNALEESISLTKSAIDLGTKQLKSIKGFP
EDTRKSLKEFLASPDGYGIGDHQKKVIRLLEFYQQAIKIQLLPTQPLLAPAPTANVQAMA
ITELSSPEPVIPFDARAHAHIADELQRLITELDFAGAVGESLADIRRQLLNGITPPLLAE
ICLQVIELIIEGTREERKSSQAFLSTLNESLSAVHFSFTESLDEGRALQSATQDTRQAID
KELRALDHTLASHDTFDELKGAISGHMGAINMLLQDREAMAARERHLLTRLSTMEAKLRL
MKEETAEYKKRLTIQKHKLFLDSLTQVHNRAALDERLELEYKRWLRYNTPLCLAIIDIDH
FKNINDNYGHMAGDKALKVVAKALQGALRDTDFIARFGGEEFVVLLPNINPDKYQKPLET
LRQTIKSIPFRFRDARVEITISIGATLFREGDHTTDAFERADKALYSSKHSGRDQVNLA
>T0PD22|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MQTPATPDNERMRLDALRRMAILDTSAEERFDRITRMARNMFDVPISLVSLVDEDRQWFK
SCCGLPVPETPRDISFCGHAILGNELFVVEDATRDLRFADNPLVSGDPHIRFYAGSPLQI
GEGYKLGTLCIIDRKPRLLDERQRDLLTDLAGMVERELAAIQLATMDELTGITNRRGFML
LAHKCLQLAHRQGRAATLLFLDLNRFKEINDRLGHDVGDDALQQMASLMCGVFRDADIFA
RLGGDEFAVLLPGTGPAEVPRVLARLDEALAGFNRESGKPYRLSCSVGVGHYDALSPPAL
DLLLQQADKQMYDCKKGC
>T0QX29|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MIKWLLTRRYYVLTSFSILLGALVLVVTLALAAVSYLRSIDKTVAGYGHMISSIEAALIH
ELVLANQRQLAVLEASLDKAAIARGEPADNPIWAVAHQIKRDSHYIYFYNSRFDRISSYP
LWIQPAEYRAASRPWYQVLSMKGDELVWFGPYQEYSSQELILTLIKRVKDGEGKLLGLLM
VDMSVNSIQQALQRAMGSNQAAIYISLRGSNRLVVGSKMALYDKANKTVDSHLLGLDVIW
HGRHLKRELEDVDWDLNIYLPPAQFRDSLNEALLMVVVPLLSLFIIWFCSISFLVRVFRQ
ELALVSGSLTGIVQDPTRPKTSNHLNTWFVHSCLSEIDQVRASFLQGQDALLHDPLTGIM
NRRAFTQRRSELDEIQTPYWLVLFDVDNFKCINDSWGHSVGDGVLCRVAELLTAELGTGA
VYRIGGDEFAALLPWERHELESRLHHLLARVRNQQWREFKTPVTLSAGGAHYPDDGLFLF
DRADECLYQSKRLGRDRWHLFPYPDTGGEPASPGVTISV
>T0QTH6|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLNKLGSNLLLIAAVTCAPLLLLQGIWLAAQATPLTLTLILGTSLLGFGLLFMLAYRARN
AERAQQDRVWIKALQLRDPAVLETAEAQAALQQLLSHFNEADLDAHRQIDELHNLATQDE
LTQLQNRHAFRRDMTALLQRDQDTQTATLVLIRATELGKLNAQRGFQSGDAYIKDIANLI
TRVVSRFPGHQVYRISGADFAVLVQPVANIPPPLLGRDLKIAFDHYQQQHELESAAYSGL
TRLSSGQKIEAILARADLALARAQTETVNGWAIQQDDDEVVDLQGQHHWKLVLNELLDQE
RISFTYQPIQPMHRSMLAYNEIYTRFSSADGTVLPTDTLFAMAQRLDMVMKLEQMLVVHI
MRQYRAFGANQSRWGINLSSNLLQNSTFLIWLDRQLLKDPNTSANLVFELDEEHLERNMT
GAKRVFELLRRNGSRSAICNFGKGIGSFNLFRELKPDYIKLDPALITGLEQDLTNQQFVR
MIVDVSHRMGCQVIAEGVEQLGQKQLLQGMYVDGLQGYLIARPQPLRPDISQLGLFTEDV
STSAESE
>T0PHZ3|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MDTILQALSVQVTEARDLESLTRPLLEMLETVTGLESTYLTQIDLEQSAQHILYARNSAA
LQIPEGVSVDWSDTLCRRALDEGRLYAADVADRWGDSAAARAMGIRTYMSSPVRTSSGSL
YGTLCGASAEHKPLVTGSEHLIAFFARLIAEHVEREQLLQQLQQANNELSRQALSDPLTG
LPNRRALMLELHRLFSLLKRTGHPLLISFIDLDGFKAINDTHGHDAGDLLLQTMAQQLAG
ALRSGDLLARVGGDEFVAVGMGPLSGEETVEAAVHCFQRRLFEQSQVQLPLASQVLNYPG
ASVGVVAVDPASISIDDALRQADACMYAVKRQRRAQS
>A0A157SQJ8|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MKQDPADLERRVSTLLADPDYAGHPLREALSDLWQHTSDVLERVERITHLSDAFQSMARE
RELDICRRFDRQLRKLSRIVRISDHYQNMMRELNAALKNASIRDELTGLANRRALIEVLK
EETERAARHSRRFVLVMLDVDHFKQINDQHGHDVGDRALIGVAGLLHDGLRQYDACGRWG
GDEFLLLLPESGLEEAKSMLERLVSQVREFRVQAPSGEIGLTVSVGMAQYRPGEAFNDTL
TRADHALYSAKQQGRDRVAADGPGPLPVDPLASPAE
>A0A157Q1J4|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MTKAAIAELLPADGEIGHAVGDRALATFAAVLRTFLRNRDVIARLGGGEFVVLLTDASGD
DAARIDPQRDASVQALRADADASMYGQKRLGKAGR
>A0A318FNP1|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MDKPMWVKKLRHVLSPGYVVNLCFFIVFCFSTLLIWREVKILEEAYVANQRNNLENVTHE
LDGLLQFNIDRMIFFRNGMQSALGTPLDFAVLRKAEQDYLEKRHEPIWSVEIHNRRTLPV
YGVADAFVESGDLLSRDTPFSGNELMASLELGYLLRLANNNRGFTERMMYVSRSGFFITT
KPPKNSTQALGLYSRAISASWFIQQTQRNNPARGIVWQTFPGDEPQRETQVVTASIPLDY
QRYWLGVLAMDFSVREMRAFLVNAVKNGQEGEYQLYDNRLNLIASSASDNVLTLLSPQEQ
EQLRSAFSHDNQGGIRLLTRYISWEKLRNFDGVLLRIHTLKEGVHDDFGRITIALMLMWL
MFTLMLMISWLVIRRMVRNMSVLQTSLEWRAWHDALTRLLNRGALFDRASEATSLSERLK
RPIAVIQLDLDYFKGVNDRHGHQAGDRVLSLVGSTIASHIREGDLAGRVGGEEFCIVMPN
TTLHEATAIAERIRVRIKGREILLRNRTSLRISASFGVSSSDDSNEFNFENLQSIADHRL
YLAKQNGRNQVCAEG
>A0A5E4T9S6|diguanylate cyclase|EC 2.7.7.65|Pandoraea nosoerga|TrEMBL
MKSTISRTEQGNRAAATTILVACAALTLAGFLTRAFEGAVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIAAHVTRAPFWLALVAEA
SFAAYVMLSVRSYARTRSDPHTRPGYREAARYGATVLFIWVGVSLSLIALVGAGRTLVTP
HLAGGLDAETLALGALFVAYVALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPS
EASYQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYF
DNRIRLVAERVQQRSIPLSVLLIDIDYFKQVNDRYGHPFGDAVLQRIANTIQHCIRLPSD
FAVRLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKARDDGESITISVGIAS
WQPGEPLIISSMLERADQALYQAKHKGRDQSVLGGGQMAA
>A0A0D6JJG9|diguanylate cyclase|EC 2.7.7.65|Candidatus Filomicrobium marinum|TrEMBL
MTVRFSNPLPLLVSGAIFLAILWASLLLSPGWLPVSVNALTFGLLSPAIWEVSNSVGQTQ
TIRYVESPNSLVFILSLFTLSGAGLYFATKRYLGNAEEGSRQELSASQRELAKDIRAEGL
RLDEELVQNIKWIQTFLRANEEFSRSLKDARTKLERSKSANKTDVVITFLLAKNSLMQKE
SADLKQRLTTSQQQIEELRAKLAHALDQGMRDPLTELGNRRRFDITLAQEAAQAQAKGSK
LSLVICDLDHFKHINDKFGHQVGDSVLQLFASLLVKNIKGRDTAIRYGGEEFALILPETG
IEGAKHVTENIRSDLEASSWRVTTTRQPIGKITASFGLAELKTDEDIQQLIKRADRHLYI
AKESGRNRVEHNGA
>S0G3N5|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MHYFSIRTRLIVVLTLILLSGFFITNVISYRASKHQIHSSIVESSLPLARDNIYSEIQRD
LMRPIFVSSLMANDTFLKDWVAAGEKQTGPIIRYLTEIQEKYGFFSSFFVSDITKNYYHF
KGILKQIHPDDDHDIWYYRFKEKNIQYDLDVDTNQAEQNHMTIFINHRLTSDERSFMGVV
GVGLDFDRVASLLEDYKAKYDRNIYMVSPDGIIQVHTDQSRILTTSIFDQPGLGDIVHDI
FAAKTQPAFFEYDAHGNHILLTSRFVEELDWYLLVEQDETLALKSIQTTFVQNFFIGLGI
TLITILFAIMVINYFQHQLEIMATTDKMTKAYNRREFERRFHFHTDANRRKTMDLSIILF
DIDRLKELNDTRGHLAGDQIIKNIAGIAAAIIRDNDMLVRWGGDEFVILTLGDTDQAIYI
AGRLLDAVQAHDFLKESTEGGIIQMSISCGVTGFVEGDTLDTVMARADNALYQAKREGRN
RVVLATDAG
>A0A3S4RYS8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MFDGLRSSSAARINPGLWRVDQYYWFTAILAARGLQTAASRLVALCIAMLGLLPVGLMTS
RLGPQGLSMRIAAIVIAVASLAMAALWLRDQWPSRGQSVFCAVFGAVAVGVSCLVISGPI
IAFLGAVMYVVLTVFVVCFHSVRLLALIWVIAAVVLGVLFARLASTDLAVAVCALTVVVL
VNAFVAFSCRAVIKLLQPNAGHDDIEQLTGLLHRDAFYRSVATLLASRSRSADQYLVVVA
VNIDSFSLLLGLSGSRGGNRARVTVGQALRETVRHNAIVAHVSEDDFLIADTFTTADASP
LVERIRGAIVATPQRLTASIGVVVTPLPPLAAEPPDEVLDKLISVATQAIEQARMTGGNQ
VRYVLRPNLDEDGHDTVGGPGDDWPDADRTA
>A0A4Q7MPZ6|diguanylate cyclase|EC 2.7.7.65|Kerstersia gyiorum|TrEMBL
MLRKNTSPEEWVADWRRICGRYGEDIWVLVQGIVREHKAFLATRFYEQMMQDAAASFFLS
AQLVQNRLHPALQAWLEGVFSVALNGDYEGTVAYQKRVGGVHARIGIPTHLVMRGTRALN
EAIFARLQDVDVVQRTNAVAYVAELTSLAMEVMCQSYAVSHDRNSRAEEAYRLFAISQDI
GAEREKQRAALLGWENQFMYEVAVNQARANLPLLGKSEFGLWFTHKAAHAFEGSADVASI
LAEIDRVDAAASQLGSMAGSSEGKDAGQVEVLRRIRDHCRTVGFLLEGLFQQAGYLESGR
DVLTRLLNRKYLQVIMNREIEFARTNGCGLAVLMVDIDHFKRINDEYGHDGGDAALRHVG
LFMSQAVRSSDYLFRLGGEEFLVVLVDVEPETAMLVAENLRRRAENERIPLGQDIHLNMT
LSIGVALYAGHPDYLLLLKAADQALYRAKHLGRNRVELSRGLE
>S0G4Q6|diguanylate cyclase|EC 2.7.7.65|Desulfotignum phosphitoxidans DSM 13687|TrEMBL
MTHKILIVDDDDAVKDSVSEYLTLISYQVDAVSSAEEALEKLETSLVDVVLTDIMMQGMD
GLELTRIIKEKYDMEVMVMTGYNADYSYEEAVKTGASDFLFKPFRFEELDLRIKRVLREA
GLKREHNRLLKEMEHLAITDALTKLYNSRQFFRQIKIETERNERYQHHLSLLILDIDHFK
HYNDTWGHLEGDKVLMAIGRIINACMRSMDTPYRYGGEEFAVLLPETDLKEACVVGYRIK
NLIGQEVFEPKPGVHQSITISIGASELKPGEDVTSFIRRTDQALYRSKENGRNCLTYDD
>A0A0M7IDB8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MLRIDLRRLILWISLLSIFLVLAAGLHASYLVQRDLLLHNALESNRVYAAKLAATTEYFL
GDLRRHLAYSADALADMETHPELMASETRRQEEQLGHFNSSFVVSAQGEVLAVSASYPQL
RGQHMTSDAARTALTTRRPFISEPFRASNGRWLILYTHPIFSRDYRYLGYIAGTLYLHED
NVLDRLLGQHFNRDDSLLYVLSRDGTLIYHPDRSRLGQASADKAALAAALRGETGEIRFT
DASRNAILAGYAPVPSTGWTIIAQRPVASTLLPLNDLLMATARNTLPLLVMSIVLIWLLS
RWIARPLGELAGIAKRMQDPDSAERIRKVRSWYFEASQLKRALLMGLTSIQHKIRDLRRA
STTDTLTGLLNRRGLNEAMALLQTAETPLAIVALDIDHFKNINDRYGHAAGDRALQILAA
LLTEGSRGGDTVARSGGEEFVMLMPGASLAAAVGAAERLRLKLERLGTDTGLPAPITLSA
GVACYPAHGATLDEVMQRADRALYYAKNHGRNAVCVADNHAADGARMALPR
>A0A8F7U423|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MTEDDFKKSTANLKKAVPLMMQNHVAATPANYALWYTYVENAIPQMNRELETILENYGIC
PPAAGEQLYNNYVAARAETDIRDLRANIEVLVGQVASSMTDTLADTSHFSRVIDKSFQNL
EKVDDQSMSIEEVMKVIRQLVNESKEIRHSTNFLNNQLETATEEIQRLKTQLAEVQQDAL
FDGLTSLYNRRSFDNDLDTLCRSEQKICLILADIDHFKGYNDTYGHLFGDAVIKGIAKRL
QTSSRDGIHAYRFGGEEFALIMPNKSLRIARQFAESLRRSVEKLSIKDRRSGKPVGNITA
SFGVAELQAGETPNSIIERADKLLYEAKQLGRNRVMPL
>A0A1V5FZH6|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA280|TrEMBL
MGRRKAISSMAESARAAKLFLRAGLLCLFAWTVPATALSPGARFVDYEQERWTVEDGLPQ
ISVMAITQDLQGYLWLATQNGIARFDGSRFSVFNRANTGLDVNLVTSAYADSVGNVWFGT
PRGVLQFGAAQPRLHQSIEDPLQVLDIIEWPQGRLLLATARGVRGLDFVPIYLQSEAIHA
FAVDGNGALWVGGDAAIWRIDSSGIRRIAIGSADTRVTQIVRYGARMAVGTTQGAFLLDV
GSGQLTDAFPELTDASIARLSADGDGNLWAAAIGELQRLRPDGAIERIDTRPLLEQPWLH
AMFEDRNGDLWLGDQRESLIRVSDSAVAVIGREQGLQDDLLWSVLDNAEGGLWVGSNAGL
QQWHPQGFFDPPVDSRRLSDSMIYSLFRDSAGRVWAGTGDGPAQVMPEGLLKPESLRDIH
GRVTSFVEDGDSFWIGTLDGLWRVRSGVAKRIDYRPGSPLQRIRNLWLESPGQLLVATEG
GVRRMVGDAILKPEWADALEDDIVTAFYALRPDILLIGTFDRGLGRLQDSKLTLLTSADG
LPTNNVWAMRDIAEHLYVSSSDGAYRIDTEALLTPLPGQLRSEVVVESVSRARGTRRMGC
CNGGGAARIAVLGQILNFPTTRGLVQLETAQFRSPASTPTPVLERITVGGVEVMPGPVIH
IDGEVRDLAIEYTAVDLRHSERSEFRYRLMGYNDQWTDVHTRRLAVFTGLPPGDYQFELQ
ARFPGNAWRSADVLPRVTIAPQWHERLPIRLGALALLLWLGLYASRRYAQKQRQQRDLLE
REVQARTLALARANERLRTANEALLQESRTDVLTGIANRRAALQALAETDRYCLLLIDVD
RFKSVNDRFGHAAGDRVLNDIALLTRELTPLPGLVARWGGEEFLLVLPHASMPDGIALAN
RIRVQIASHSFGVAPQQSLRVTVSIGVCGHPTQGAPASAWPLALELADRALYRAKSSGRN
RAVGLSVLALPKGWTGLDTADIDVLLNSDAIRWHLSDH
>A0A8F7U149|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MNHKVLVVEDSRAYRRYLTQQLSSIGCDVIGCESYAETQKALSEHRDFHFAVLDYCLPDA
QDGEVIDLVLDNKQKVIVLTATFSDKIRERFIAKGVMDYLLKDSMASVSYLLPLANRLMN
NVRHHALVVDDSPTVRKHVAQLLEHQYIRTTQAQNGSEALHKLAETPDITFIITDHDMPS
KDGIVMTREIRQMYDKNSIAILGLSGSGDRTLTARFLKAGANDFLHKPFNQEEFFCRVNQ
LLDMKEATDELYKLANQDTLTGLWNRRFLFNQSCTEGSARYIAMLDIDHFKSVNDTFGHD
GGDTALKTIANILKIYFPEDVVVRFGGEEFCVQSYATLDEFITRLEKMRQRIENSIIKHN
GQDITLTISIGVCSLEGSLEQQIKLADDCLYVAKEHGRNQIIATE
>A0A446CG76|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MRIHLRGLVLALTIFSAVVATANALYASYRVQREQLIANTLEANRVYAAKLAESAGAFLK
TAQRQLEYSARHLAARFEVPDILAAEAARLQEQTDSFNSVAIIRADGTVLAASQSLRGFV
GTRVDNDGSRAALQARKPLISKPYVSLSGNLLINVSHPIHADNGRYLGYIAGTIYLRSEG
ALHMLLGKHHYQDGSYLYVVDQEGRLIYHQDTARIGEDVRSNPVVTAVMRGQAGSQRLVN
TRGVDMLAGYASVPLSGWGVIAQRPAKATLEPLDDLIWALVKYAAPFALAFLLAIWWCAS
KISQPLSQLATNVEHQEVSVAMQRVQSVKAWYFEAQRLKRAVIRSFTNLQDEIGKLNQAS
ITDPLTSLHNRRGLQAAVERLEAARAPFAVVALDIDHFKQVNDTYGHTVGDEVIRGVAQL
MRDCSRPSDVLCRNGGEEFLILLPAASKKEAANVAERLRKRLETHRLHGTAGITLSAGVA
QWPSAGPEVHAAFRAADEALYVAKQQGRNRVVTHAA
>A0A1V5K4X8|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin506|TrEMBL
MAFHAAVVGGCVAVLTASHWTASATTVVVASVASAVVSAVVAWNAQRLRVAGSPLALAEA
VLVTLAVRATGGAGSEAYLLYFPVIVANLLEDQRFGYGLATVIAGMYAAATIPFAAAGPD
DAVAVALYRAAALLATGVGTSSISQRFAQCSRAASAVNAKLKMRDHWDEAMLRISRGIDS
GLGLTDTLGLILDSGLGVLHGDVGLVVLKDRSGRYTVRAARTAGGNILGNVIDPSEGAVG
LCMERRMTVLYPGAGSSGMRFREVEDFHLAKMIATPLFAGSEMVGAIAFGDRRPGELYGY
DDVEFIESLAKQLSVVVVNANLLEEARRRADYLTSLNQISMSITSVLEPYDLFEKIYKSV
CQVLPLDAFFVALPLDDPTQAEMAFLMDKGVRSPSSRLPLGDSPTGKVMRSGRPLLANLD
ESSDTQGFSIVGAADDDDVTRSVMIAPMKAGNRVVGAISVQSYTPNAYGEEELELLMTIA
GSAAVALENSQLYQAAREQSITDQLTGLGNYRLFHEVFSREIERSRRYSTPLSLIMIDSD
SLKDINDTYGHAVGDMHLRHITKLMTTVSRKSDYVVRYAGDEFMIILPNTGGAEAMAMAE
RLRSRVEKTPFTVDGQELSATVSIGVASFPESGSDVETMLKSVDEAMYASKRVGRNRVTR
ALAAVTRSS
>A0A446CKA4|diguanylate cyclase|EC 2.7.7.65|Achromobacter agilis|TrEMBL
MVRRATLGLVVAWLVLVAGVARWLSQEVVASRLDSLAASAEYEVKITARVMDRLFTEMIS
VANMVARQGQVIQLAMRYRTDPPGAAELTREERAELFTRDPLVRKVGDFMNLLASDLRYA
RIYMNNMSDDTVTASNWAEDDSIVGMIYSGRAYLNDALRNGNGSYFGIARLNKSPSYFVA
SRIEDADDVPQGSVTVKFDAPDVALYLAGRHIALVVNRQGRVTTASSAPFMLRNVAALLP
PDMVLPSDGDEDPGDPMDVRAIADSSHADQWLIDGKPYLVRRQPLSNSQYQLLALASLDE
VAPMRRQHILAAALVAMLGLVLIFLSSHAVGQLVMRRQDERHAANHDALTGLLNRRAVVA
ELDRYFSLAKRTQRSVLVAFIDLDGFKAINDTYGHDIGDKFLIEVGRRLSAGLRAGDILG
RWGGDEFVVAGLVASSSAHDPDAVVEAMRKRLAPLLSGTYTFDECSFHYPGASFGIVSVD
PSASSLETVLKDADQLMYADKQARRAMQMA
>B7MCL1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O45:K1 (strain S88 / ExPEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7Z7LFQ1|diguanylate cyclase|EC 2.7.7.65|Mesotoga infera|TrEMBL
MLVKPVYVSLTMANDSFVKKWLEKEYEGDSTSISNYLSGIKDKYSYSSAFLISANTLNYY
NVEGLFKTVSKEDPHDVWYYSFVDENSEFRLDIDTDQANKNLLSPFVNCRIDDSEGNLLG
VTGVGLEISGIREIFSYYNRLLDIDAYLIDSHGIVRLHEDEDMILKGSIFDDPELVRYKA
RILENLEDFDVIEYKNTPFENYLVSRYIAEAGWYLIVTKDTTTLNNSFRKQLLYDIMIIT
VVLALFTIIALKVISANQKRLSTIAMTDALTGIYNRRALMEILPIELSHGKRLLYPITFV
MIDIDGFKKINDLRGHIEGDRVLREFGGILQISIRKQFDSAFRYGGDEFLVCLPDCSRED
VNEVIERIRKLSSIKGIVFSTGIQTVDPKNDNFGLLEILSLIDKELYVNKGAKDRSST
>A0A8I0FQB2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. C1|TrEMBL
MDKGISPITRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RSLEASLVFSDSVAANETLAALGQQGQFSVAEVRNKNQKVIATWRYDAQDTTEKISGLIS
HWLFPQPVTKPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDESAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNHHQPYRLGGDEFAMVLYSVHSENEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKHLRSERIIKK
>A0A2T0B8R0|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MKVLKIVRNVLIKNKLDKSFEIELAKRNMITAKIMMTFIAIFQIYDIIYTIFKKKNIYTF
PNYIYMTLYISLLIATIGILYLVIKLSKNIERNANKILIFSTIYSGLILLWGTGVTVLDF
KNSDEIIVYITIVIGIAATSYMKPKISIIVLSLNCIILLTLIININTIFPNYEMFKIDHQ
GLYVNIVIFTIMGISASIMRYINKYEDFRHRHIIISQNKKLNEMNNELNRLNAYLKSISK
TDCLSKLYNRWCLDETMQDQLQICIENNTSLAVLMMDIDDFKSINDSFGHEIGDNGIKMV
SSIIKKYSEEFSLSSFRYGGEEFLILMPNFDKRDAFRIANDIRTDISNTEIKDTNINLTV
SGGLHCCMPKTKEEYDDFIVKSDRALYKAKDKGKNFIEVYEELVVSQI
>A0A2X2J2Y8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGTWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVALPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILEHAESVQKLRLAGCRIVLNQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2X2J593|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVL
TGLPGRRVLNESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLAS
WTRDYETVYRYGGEEFIIIVKVR
>A0A398TTY8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRQGAEVIMKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNMHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNRYLLSTAHNAMDYIRKNGGNGWQFFSPA
MNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSR
FIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDA
MQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTDFSGLSRLVSLP
VTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVI
QGYFFSRPLPAEEIPSWMSSVLPLKI
>A0A7G6K431|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEVLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIFVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1S9IWX6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFLHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8H9ADA4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMTLVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDANNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8E2TG24|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2P9GWY5|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MAQPPSPPPVAAVSRLIAAGTTVTGGEPLVAVGKFAKVPLPGSSATPSALAGAAPEPTPA
APSAAAPTTAAQAPNAPVLPDLLAKLPVLAWVVDTNGRVVHAHSSEVRRWGMKIGPSMRP
RWWDAFVYQARSREAFLKAVESAVVGRPTYDLLIERASPSGGRLALRSHIVPVSWPDAKG
QEQPSALVLDTIASARELMEYERVRRRKDHYKSLVEASPNLIWACDSSFRFTFVSRRACR
DLYGYAVDDLVGASIGVLLNPSADQTRARRALVALRDGRVMRDVEMSHITKDGRRIIVAV
SAAALAGSNGGFSGAVGIMVDLTALKQREASLAEALRVERSVLDSAGQALAVVRDGAIAR
CNDAFLKLLQHSARDLQGIRIADIFAERSEWVAAMAAADRAALTDQAVVREIKLRRSLQG
PPDEQTVWCQLTLRSVERGEYVVALADIDSIRRREAHALFDARHDELTGLANRRLFAERA
RAAMATSALRNAGCAIVVIDLDRFKQVNDRFGHQAGDEVLQEMARRLQRVVRPQDTVARY
GGDEFALLIPDAGTRRDIEAISNRILDELSRPVRVGGRTDETLSASVGVALAREQSREPS
LLLSLADRAMYEAKSAGGNQAVFAPISDPVAELAAPSTRVDRAA
>A0A0R3K1W9|diguanylate cyclase|EC 2.7.7.65|Caloramator mitchellensis|TrEMBL
MKIINNRFRIIKKNYQNQIITSYRVADLKSSHRTINLNILNSDSMDKKLINYCIEEFIML
SNIKNDNIIKLHNFYVIESIDNGQIKDKTYFFTSDRVENQVSFNMIEKLSLQSKIELFIK
LCRTINYLHLIGYNYLYLNLLNINLINREGDLDIVINDILTSKINDKLYSSKKGNLLFKA
PEVIKSDEVTNQSDIYSLGVMLIAFLLGRLKFTNIEEGIQFLYGLNKQIPSGLINIIKTM
TRENPDDRFENINAVIKELNCVFNSNFNAIDLENLGKLNDKIKICDRKSEIEKILDGYKR
GAKCAIVSGETGIGKSRLLKELEFKFKINNIESFSFFGNYETQSKKVVSDIIKQMFINTN
EDLIRQFENDFVSILPELKSNNINEFTYDEKTKIRLLNSFYRFIKQRFGSKKIVLIIDDL
NEIDSFTMDLALDLVNSDLNEQIFFVISYKEEKSTDKKFKDLLYTIKQKDRTISINLEGL
SEDATAEMIKCKLFMSYTPKLFANKIYSITMGNPLFIEELLKDLYIRKILYVNPISGIWS
SQYDDNYDNMILPTTVEQAILSQIRGLDEMQMNILEIIAMFETSASLEILKNTINLDADT
LTRVLLQLESTGVIVFKISDEGYVYDFRNKLLKKIIYSKIDENKKKFLHKKVAEIIEKYA
DDFISFALNDELIYHLEKYGDKEKAAKFCIKNAELMKQFKNMNDAINYFEKAISLFDEKI
EDEVKLNTFFETALLYYQTGNIQKALHYYKLVLNISLFLENYKDAIDALNFIVEISLNKN
ELESAQINLRKIEEIINEKEKDYLKGYLEYRYNLAIYYRELNDFSKVDEIARESLKLIND
EDYRSRGKFIKLLGDICLFKSMPDEALKYYEKSLSCFDKARNKVGMMTVLNNISIIYSDY
YQDYEVSLKYLKDMLIISSAENSLTIKALSLLNIASIYYLRFDYEKSLKYFLEALAISES
LEFEVYVFYIYCYLIGVYLRLGQVKSSYDYYLKTKEEIEKYPNQGKYESLYYYFSGELFY
YLGDFERAKSNLERVVEIYNQDYIKTKWDAEILIEIINIKMFREEKILKSAITKILDISA
NYQNKFEKLNIYYNLLINCHKIADENTKNLILNLINNNDLNDVPKIIRIKLDYLKHVLKV
NKGQLKQIELLLKESKENRLKQLYWRLSVLLGDTYYDEGNIFMALNHYANAIQQISSIVS
EIPIEYKRSFVIAKNALKPLCKIYEIKGDYIALKETCIEQLSDKTIDEMLSYKHVKNVLY
DKHLINNTRRIIRNELKINIKSFEDLIGKLILNPLVDLDLISKYLAYVTLATRCLIVSET
NELEILASSNENKQLPDDLTIFNTVKQIEKPVFSTDTVTKDNSIYSYACIPLVKRNFKDR
KRISTYDIKRVLGYIFIESDKIINYINEESIQECIKFSNIVLELIDKNNIINSSIFDKLT
RAYTRKFFDDAIEEHIQNAENSNGYFSIIMIDIDNFKKLNDKFGHQTGDKILKQLGNVVR
ETIRKNDLFCRYGGEEFIIILPDTKKNEAYILAERIRNKIENTVMLFNKSITVSMGVSTF
PEDAEWKDELIEKADKALYAAKENGKNRVEIWREDFENKGRVTNKLSGLLTGNEVKDSAK
ILYLIELSELSKANIDTLNLIYYLLGILLESTESKYAGYLKVKNNKIIESYWRKAFIDGW
IGFNYYNMNLINRTISEKEGRFLIDWEEYFEYDQIKNIPVFYSVMLVPVIKRQEILGVIY
LATSSNEKEYKFEDFNYVSILSNIFSALI
>A0A0R3JZK1|diguanylate cyclase|EC 2.7.7.65|Caloramator mitchellensis|TrEMBL
MEIAAAIIAILFAIYLIVNNMKLKSEYQRTEKIKNTLIDVAKEIEDFKSIDDLYQRILEY
TIDLIENAQRGSILIYDRNKNHMEYKAAVGFDIESLKNVHLRKEELYLYRTTKLKEPSII
KNPRVFDDEHLSKKSFKKLVESNALDIKCTISAPIYIDGDFYGVINLDNNIREDAFNKRD
IILLKYIVIQLEAAIKIVKLMNELKFISSYDHLTGLLNRRKFEELLNDLLSTGETLSICL
IDLDDFKYINDTFGHKKGDEALKHFTNAIRKQFDDNAYICRYAGDEFVIVFKGSKKILRE
KIDEIKEFLDTNPVDGINVKFSAGYSSTFETRNADKLITIADNEMYEQKKKNKLEVR
>A0A3D1C1A4|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A2X3CR05|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRSVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFLPNISITPHAVGNMADKRRTTHLARRWPDGHLQRRTWEWN
MSHWISWW
>A0A2X3CE96|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTLPVFGISGSVAGDNPILLVDD
PLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDESQVIRHYSQALG
APWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIK
AFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPREQELLSRAFVHDNQGGLRLL
TRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVR
NMSVLQTSLEWQAWHDALTRLLNRGALFEQAIAVASDCQRSGRPLAVIQLDLDHFKHIND
RYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQ
GREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADGRLYLAKQNGRNQVCFRSAA
>A0A5E4UHT7|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MSHPLPASHDVDTPHDSPDDIAHDVAQAARALWHTNGTNTTTGSTPPHLPTGDERGRIDA
VPDIIDRASPLTPPRRDMTASGADFHALHAPASPPKHDPTSDARLDETERLAALRRYEIL
DTPPEPAFERIVHLASHVIDVPISLVSLIDETRQWFKARQGIDTAQTPRSMAFCAHAILE
DDVLVVSDARADPRFADNPLVTGAPNIRFYAGAPLRTPEGHRLGTLCVMDRRPRTLDAEK
RTLLADLSALVVDALELRRVNRVLGDMAMRDGLTGALNRRAFLVQAERQFSAARAQQRRL
SVLMLDIDHFKRINDTWGHAVGDRVIVELTLIMRATLRKGTVIGRLGGEEFAVLLPEADA
QRAVQAAERLLIAIGGASMPGASGSKGLTGPIRFSASIGIGSLTPDDAEFGSLLQRADRA
LYAAKQSGRNRVAVM
>A0A377YM29|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWSEINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVIRHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAIAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAWRSDCASVFRDGKSFCITT
>A0A485TKQ8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLKHVNHVAKRFIIYVFICLLAGFGIAGVTAFFHTSFSTTSSILFPLLTSFLMVFHITIA
CFMGMKYWSSKRRLYLTPVAFGFACSALLMLGTLSSYPDWLTCSTTPVINQNDAVIYYFF
RNIMMAVLFMSSIVLYYFRQRIMHSLKAHIITFAACIVFTLTIIFLSWVYSSHSPWLSIN
FIDDLSHTFTPLWQSIIGWLLMAIWFITLILLISLSKLRNIFWFSGAFFCSAYLYTLFQL
VSTAGDLDQTWYQARFFETLCTLFLILVLLVDVFMLYRESNHKYVNSYQNSIRDPLTRLY
NRSFFYDTLNQQLAKVNPQHPLSVIISDLDHFKRINDNYGHVAGDKVIQFAASVLENHSR
ADDAAARIGGEEFALLLVNTAEKDALAIAERIRLAVNAEQHPLPERMTISMGLYTTRDRS
VSAETCVERADAAMYEAKNSGRNRVVVWRHPGD
>A0A486T9R2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVEQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A377W0W4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRTKHTWQINTLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIR
LMLCIIHDITEEVHLKKELEFSAAHDPLTGLA
>A0A377URK0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLEHGG
>A0A331A3S2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDASAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQLRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A377TYN2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTSLSSYRESNHKYVHSYQNSIRDPLTRLYNRSFFYDTLNQQLAKVNAQHPLSVLISDLD
HFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEKEAQAIAE
RIRLAVSAGESHLPERMTISMGVYTTHDNSVTAEACVQRADEAMYEAKNNGRNQVIVWHR
QGG
>A0A2Z2NN39|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MPRIFSHDTEETGSDFRSKATLGVAITAVLLLLPAVLLDLLKGELAIGIGAFCVVFILSA
NAWIVLQGRCHQRLTQYGLIPAGMVFMTSIFQMDGLIASLWCYPIVLAAYCMLSERRAWF
ANAVILLLALPMVWLTLDPTYAFRVTTTLVATSIFAAILVWVIDDQRRMLEMQLTLDPLT
GLLNRLTYTKRMEQAVHEHEQHGKRISLLAIDVDNFKKLNDHHGHAVGDYVLSQIGLLLK
NALREEDNVFRMGGEEFTVILINANERAAIETAERIRRQIGEHDYGINSAVTISTGVAEH
LQDESWAAWAKRGDDRLYEAKHKGRNRVVAAQPKEVVKLGIVSLP
>D8G7E7|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MNDDKNQGIDPLTQITNRKQFEKYLEEQWQHLALEQKPISMIYCDIDCLKTYNDHYGHSI
GDDCICQIAKNIRDTASSFVDISVTARCGGDEFWIILPNTDATNAIEIAEKIRSEVNALQ
IFNESPNLSRFVLSKFVTLSLGVSTTIPDINVLPGELLRAADTAIQEAKNDGRNRVIFKE
FTA
>D8FTC9|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MASTGFRHQSIFVNAQRLEDRSKEPPSREYLLLEIEQLRQELQEIKAEKMQLDILLEATC
ARADAVEVLLHESHQQLQAEIAERERAQAAMKEAQAELQSVQVTVSTDKADMEMILETMR
EHGDFLENLLHDQCIRDPVTGLFNRRYLKEFLTREIERSTQAQQSLGIIMLDIDYFKRFN
DTFGHDAGDLVLQELSLFLQRCVHNSEIVCRYGGEEFVLVLPESSLEDAYQRAEQLRQGV
KQLNVKYNGQSLDVITVSLGVACFPEHGKTGAEAIQAADVALYRAKAKGRDRVISARSRF
>D8G4D8|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MTLLTNDPMEILKRKAIIFILVFMVLGGILITFLHLLEGTTHTISLVIPPLTSITCLNLL
IYLIKYPQQIYRVINLLLAWSSFIIIFPEYSFVIEAWLDKEKRLIDTLPPISSGLFLLTT
SMIIFLRPRRLVRLTILLWFIIAAPVVVYLIFHIPELETPRGIDLIVTLVPAMAINLCFI
RFYSQLQDANNKLYLERFHLMEISEKDALTSVFNRGAGERILQDLINQSEEQIGIILCDI
DRFKQINDNYGHLMGDRVLQVIAQSCQNRLREKDILIRWGGEEFLIVVTGDDEKELKQMA
EHLRLAIADRQIPEVGKVTASFGVALRQPDEDIVELFARADRALYRAKGYGRNQVIAA
>A0A3M2RJK1|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MTETRLRTWSHSVAYTLAAVFISALAFQNLRYGFYPLFYLASMMATLLFAGLIYTFISRR
QQLSAPGHLVILSLLNIGLFISCFTLDAPGISHWAMPLLVLNLTILPLRQGLALSALLVA
TVSVSLWIRQPLADALISSSGLALMLAVVGLYIWGYDYMAQSAQNLSTTDPVTGAHNARF
LDETLQKEISRAIATGHPLSVVSIGLNHADEIRDLHGKNGLQNLLKNITEHLFETVRTGD
TLYTVNESEFFLILPFTPEEGVRVIAERIRRNLIEQDWPEVGKVSVSLGCTTRGNGDTST
YSLRSRATSAMEEAHTRGANSAWFSPGEPVKA
>J6I468|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. OBRC7|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>W6K6Y8|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MKAPAIPRNDALRLLALENLCLLDTASEERFDRITRVAQAHFKVPIALVSLVDKERQWFK
SRQGLDATETPRDISFCGHAILQDDVFVIGNALEDERFADNPLVTGAPKIRFYAGAPLFA
PGGERVGTLCIIDVEPRHLSTEQVSTLRDLADGVEAEMERTALLQASDTASELSLIVEYS
ANSAIVTDAEGRIIRVNRGFEKLTGYSQEEVLGRKPGHLLQGPDSDRDVVARMSKARAEG
RGFAEQLINYKKNGEPYWIDIRAKPVRDKAGKVIKFVAIETDLTEQRIASLNFENQISAI
NKSQLVAEFETDGTIITANSLFCQTVGYDCKELPGQKHAIFMPEQERDTDSYRDFWKMLR
QGIHQSGEFRRVAKDGSDVWIQATYSPILNQKGEVTKVVKFATDITEAITNRNLVKDQAA
RTNAILETVVDAIVTIDRDGTVENFTPAAQKMFGYRESEVVGKNVKMLMPDPYRSGHDQY
LRSYLETGQAKVIGIGREVTGLRKDGTTFPMELAVSEMQVGGRRMFTGIARDITDQKHAA
DELKRLNDDLSQRVMALDAMNEINAHLHQMNAYFQTAESEEELLGALVKFCQRVFDEEVG
AYFTIQSNKMVEQILTWGRDFKGETDFKVNDCWALRQGEPKVLSSRDDHLICRHLDRDNL
DHSICCPVTTRDGMVGLLSIYGPRSEAEIEAQKIDRLNRNREVLEAVAERLGTAIANLKL
RERLHHESVRDPLTRLFNRRFFDETFELEMRRSKRADSPISVLLLDADHFKRFNDDHGHE
AGDLVLQAMAEILRDSCRLEDLPCRYGGEEFALVLVGMDKGEALEKAETIRKIVELATIE
YKGNPLPKLTVSCGVASIPEDALEQSECLRLADKALYQAKETGRNKVVGAGAA
>A0A087EFI5|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium tsurumiense|TrEMBL
MNKPIEASIVVVDDEPSIRELLVASLHFAGFEVATAASGSEAIEVIEKVQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTQEQVEDDPIIRVGDLEINEDSHDVSRAGQPIELSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGIEVTEDDGTTHKVTPLIETKRGIGYMIRE
PKGN
>A0A6N2RYY1|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MPNTPKETIKGFFEAYLGQRDLAKTLSYLLPEVQWVGTGKHEIVRTIGEAEEALKAEFAA
EPLGYTLRFWGEKETCLGGGFAMYFTHLAVSRGEDEGKPVTLEIRVTAVCREGKIASIHA
SVPTFLQEEEEYFPMRFGERTYSELTKAVRANAAQLLYRCIPGGIVGGYMEEGRPLYYIN
EEMLSYLGFTCDEFLQATGGLLVNCIHPQDREKVKERITAMLDSGDFYEVDYRMLCKGGQ
YIWIHDIGKRVQAEDGRPVALSVCYDISDQVRLHQEMEQAAVELQGKNRELKELANNIPG
GVVKCIFGGDLRTIYLSEGFCRMLGYSAQEIALGGSFYDFLWEEDRTRVQSELERAAEDI
CAKGSSLSLEYRLRTKGGSHIWVQETKRAILEDGVLYGYSVLMDITARHEMEQKLKVSEK
RLSIALDQTTNLVFDYHIPTKQISFTEGRYQMDYSTLENVPDSVIQEGRIAPESLKDCRE
MFEDIQRGEKAASSEVLMRYTGEGPFVWVRISLTTIHWEDGRPVTAVGVMEDITARKEAE
RSFLKEEQYRQAMLSSMDAYGEINLTKNRFEKISGLWETYLAVKGTSTYQEIAEANSRRF
VHFEDWDNYVSVVCRENLLRSYAAGNREIHCQHRRLNRDNQMVWMLLTIHLLADPDSGDV
KALAYLKDINREKQRELELQYQAKKDPLTQLYNKGTAEALIRNILQEQKGSHTFFILDLD
HFKEINDTYGHMFGDIVLSQAGKVLSQLFRSSDIVGRLGGDEFLVFMRNVPSQELVLRKA
KEMCNAVSKLFEQDKGVFCSVGVSCCPEDGRSYEELYRRADKALYAAKNNGRNQFVLYRE
VEHGSQEGSFQLTNIDQEEPGNASGLSAVLERRYLSEQLLDQLDAIVYVSDPETYELYYV
NRAMYSSSGYAEGECVGRKCYEAIMGRSEPCPFCTNDWLGFDKFYIWRHYNEVLRREYIL
KDKFILWNGKKARMEIAIDPNTLAE
>A0A7U7IHZ5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae Ecl8|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRSMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLEHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>N9BIC4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii ANC 3681|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAGLPLENNHYMLSYMLQIMGFATEIMCRSYEANAERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQTQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A2U3K6Z6|diguanylate cyclase|EC 2.7.7.65|Syntrophobacter sp. SbD1|TrEMBL
MNSQHDSDSLTGRTERLCETVIDALHELRSATSEPVTPSLLSQSLIKHGSYLDVLNATAR
SAGLQGDSLDIEPYAGQLQQFQLEILRVFRETFSEATGPRPEELSMLVRKAVDFAGVLQL
NGQILDFITEASDKVSIRQKDLVDLISELTRNLVEVENFVTASYSDASEVFRGSKAFAET
LENNVREITASLQTTHSTHELKSLITSKLEGIKEKSRKKLQADAKQLMKLAGQVKELKSQ
LKSIRTQISKAHRRAEQMEQVSLLDTVTGIANRRAYQKYIREKWAEYKLTKGAFSILMVD
VDNFKSINDLYGHWTGDKCLAQLAKRLKVNLRGTDFLARCGGDEFIIVLPETEAQGAETV
AQKMCEHVQRTRFLFRGERITLTISIGVSTVNEADQNIKSTFERADRGLYKTKENGRNCV
SVIL
>A0A011QJK7|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. BA-92|TrEMBL
MALAVIAVLTIAAQVVMQWVLADQKYDSHVVNIAGRQRMLSQKITALSYYISTAASGDED
SRYRGQLDEALKQWERAHAGLLRGDSELGLPGRNSKEVEDLFGPLQAHHEAIAAAARAIL
SASGNIATLARYIDNIKQHEADFLVGMSDIVTLYDRQANARVVLARWIEIALMSTTLLVL
VLSAAFICAPATRRIQRDMKELADREEDLERLFSASPTALLLVLGEKLTILHANQKAMDL
LGLPLDAMQDTKLLPLLAREQDANRSFLDKIRNGDTLNECEIFLHDAVGSTFEALVSVRS
ISFSGQAVLVLGITSISEQKRAQQALEHYATFDELTGLLNRRTGMMMLAKSMARLQREGG
RLAVCFVDLDGLKRTNDDFGHAEGDWLISSVAKVLMRSIRASDGAVRLGGDEFLLILHDC
DLDEGSRLLGRAERCLQETAVAADKPFPIGFSYGLAIYTPENDATPDELISAADSRMYRA
KQEKKRLRSAS
>A0A1C3JSJ2|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MTKPSRTLSILGVGLLSITVVVTLVLVNTVRFDGSLRALFNRDHGIYDHAMVDRSKKYLL
NVLPLIETLNDAAEENLAVREEALAQFDLAYAYLNVGRYLERYECVQPALDDILTLRDDV
EKGAKRAFRYQIWAEILTCYEDVGRSQDELKANLMERALIDSRANQFWMNVGVISVFALA
IMLWFLLEIQHRRGHKSETEKEAWQSRAMTDHLTSTYNRMALHETLELLVKQWPVASESV
GLVFYDIDHFKQFNDSFGHVAGDEALRQVASTVNKLLPNPSNHYRFGGEEFFIVNRETEH
SEVVALADQILSAVQNLNIENPNSDTGVLTVSVGVYMLEQRDYTAEELIMKVDELLYIAK
KHGRNRVVDEFTGQDI
>A0A734AQ59|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQIAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFMRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C3JS64|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MGLLDRYYAVIDTLPDHMFLFSESGRYLDVYGGDENKTGFDCKPFIGKYLHDVMPHHLAD
DFLSLIRTAIHLQETQIIKYKFDEDEMIELPNHVMVPKEIWFEGTIKHLPIIEQGERVAL
WIAKNITRQHYLELELKTLSEIDELTGILNRRSFSSILKTHVQDYQHGAKPFSLILYDID
LFKRVNDTLGHATGDEVIQHVVDVFRSELDPEVSFGRIGGEEFAILLPEKDIHDAHELAE
KLRQRLEKSPCETEFYEIEITVSMGVTQVNKDDQDTLALISRADKAMYQAKKEGRNRTCK
YSNSSEREYTQFNQCNWFKKK
>A0A5F1EIA0|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4702|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHQAMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8E5MUU1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Dessau|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379JVP3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MSQANKPPSIITLYPEETREAAELLKQAVPLMMRHAIPPNPVHYALWYTYSRGSEPELNR
RLDKVVEDFDVFPPETASRLFRDYIIRGELEEARAGQQQVIELVDDIEGDVSSSVIGSQH
YQQSLSQGLSALQEPIIDDLPGVLSELQESTQLMHDQQEKFLYRLRAAQQEITHLRSQLE
RAHLAATLDSLTRVFNRHAFTRLLERALNESYQGLALVILDIDHFKQFNDQYGHPLGDRV
LQHVGQLLRDLLPPEAFAARYGGEEFCVVLRNCANLNEVLDFAEQLRHKIQSLRIKVRRT
DQFLDSITASFGCAMAAEGDTFESLLTRADDALYQAKRAGRNQVHPTTSETMLSA
>A0A379K1Q3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MPRRFAFLLALLLGLSITGPAAASVVLTDASSGMPLNAHIELLEDTQGTLTIDDLASPEQ
QSRFQPANGRASVGQSLNPWWIKLTLQRDMRAPAHWVLEVGSVTQLDLQLYLPDGQGGWQ
LRQSGERVPFSENRDHPYRRMVFDLPTLGEQPTTFYLRAFDPAGNSFPLRIWQLDDLTQL
ATRENLALGVIYGVVFALLLYNLFILISLRDKAYFWYVLTTAFALLFIMSMTGHGAQYLW
PNHPVPAWLDRITLPSLWGLFASRFTQTLLQTRVYVRWAHHLLNMACVIYLIAIVLTLFD
QRYLAAWAIALLSLTSIPAALGSAVIRWRQGFFPAQLYLYGYGLVLGSVAILLLRTTGVL
QPAEWNAYVFPLAVAAESILFSFALAYRIQILKQERAVALQQADREKTARLAQLQASADE
LQAAVTARTAELAATNEQLRDRERELQHAAFHDSLTELPNRRYLVERSESALAHAERHKE
SVALLLIDLDHFKPINDRFGHAAGDLMLQVVAKRLREQVRAGDAVARLGGDEFAALICGS
DAESQAREIAERLLAELSEPVHYGAERLRVTISIGVALYPLHARNFTGLYKAADMALYRV
KELGRSDSRVHGDDGELSEQACLELDVLKVPSGLA
>A0A655YBN0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMEMXXXXXXXXXXLRDA
KSMYAAKIIRRYLTACSDFHSALSSVRLSPPLTFASCTTLHRLVLLQTHLNSLVLQVGGK
>A0A0G3WBB6|diguanylate cyclase|EC 2.7.7.65|Clostridium aceticum|TrEMBL
MKKKLILSKTIVRSFIIFVIAILLVTWVMTIVAIRNEKETEFKNAINNNENLTLVLEKHV
SGVLWHVESQFFSLRNYEYRANVEEIQKILENIVVSRPDLFNLISIIDSDGNVKVTNQKE
FIPTYSGDRDFFIYHKANEDLSIKMNRPLLGRVTGKWYIPISLRLENENGEFEGVLLASL
NPYYFTDIFQELNIGKKSLLFMADYNGIIYSGIYDENELELDISIPVERLSPVIERGKPF
SDRNKSFIDEAEKIRSFSFVGEHLLFVSVQTDIEEFLGSYRTRTNLRIIALVLLTIIIIV
VLFNIIKAVRSLEEKNKDLLITEDILKESESRNHALLEGIPDLLFVFNNEGFFMDFHNSN
LDKILVSEEGFLHKHVTEVLPVELAAITLEKLDIVLKTGETQVYEYSLTIGDEIEYFESR
IVYSTENSVLAIVRDITERKRTEESLLASESRYRSVISVSNTGVWEYSNKKKYLWCTKEY
FEMLGRNVSDYIMDGTANINEVWVELLHPDDRDKAFSIFMEYLKNGSVGMYENYYRMKHA
NGSWLWIWSRGQTLKNTDGNLSNLTVGTHINITELKEMEFNLFNEKEKFKTTLISIGDGV
ISTDIKGNVLIMNKVSEQLTGWTQEEAVGKPIEEVFYIMNEFTREPCENPVKRVLETGET
VEMANHTMLISKDGTERPIEDSAAPIKDESGNIRGVVLVFRDFTEKKRSQDEIKYLSFHD
HLTRLYNRRFFEVEMERIDTERNLPISIIMGDVNGLKLINDTFGHSVGDELLVKATKILK
DSFRADDIVARVGGDEIAVLLPKTDASEAKELIKRLQTNLKKEQVRDIEISISFGCETKI
DSTESLALVLKKAEDYMYNNKLFESPSVRGRVIDNIITTINAKSPREKAHSERVSQLCIA
IGDALKMGEYDINRLKALGLFHDIGKIAIADDILNKPDKLTESEYKEICRHAEIGYRVLS
AVNDMSEMAEHVLYHHERWDGKGYPKGLKGGSIPLPSRICALADAYDAMTSDRSYRPAMS
NEDAVAELKKNAGTQFDPELVEVFVEQVLPEYRNGNTD
>A0A518K6F2|diguanylate cyclase|EC 2.7.7.65|Botrimarina mediterranea|TrEMBL
MPNTLLSTADLATLVLDATAAAYAVCNPVSGEVVWANRRFCGLFPTGFDANDLLKGRRAP
DGWRLETRPLDPTAEGASQSPEALTPGSLTPESLTPGRSAPERLVLVELTPVGGENPPDP
RRETDAVTNVLARGVIMATVEQRFAARQRRPFALVFLDLVDFKLVNDRHGHLVGDKCLAE
LGSRLHQLVRAADAVGRYGGDEFLILLDGVHDAATYAPIRDRVIEGIAEPIAIGDLVLRL
GASLGVAYSTDGYDDVEAMLHAADSAMYAQKRGASLSGD
>A0A3D3M7D2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp|TrEMBL
MPSVSPEIQAREWHAMVAQFSPALTQALKHLVQTHKVDLAARFYEHMLADPNASLILSHD
EVKSRLGSSMQAWLVKVYSARADEDFLPLVALQKQVGEVHARIDVPLHLVLSGARCLKKQ
LFQLIVEQGWAAEDHAQILRLSSETMDLAMEIMSHAYSRSHDRNSRNEEGYRLFSVLQNI
TTERERQRGALLDWENSLMFDLAMGSSGVNLPRLAASDFGLWFRHKGAYAFQNTAESEQI
LLVIRHMDEQLLPQFLAAKGDETARMGLLREIRDQTKSLMFNLDSLFNSANELESGRDVL
TRMLNRKFLPVVIGNEITIAQKTGQAFSVLAVDIDHFKAINDTFGHDAGDLILQQTAEIL
SSHSRAGDYVFRMGGEEFLMILVDINNTNALKVAEKLRRKIGEEKLNLTEGRKHRVSVSI
GVATYSGHPDYQHLLRQADQAMYQAKQDGRDRVVSYEAIAN
>A0A7Z8BJG3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LRPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7Z1D6P6|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MVIRGMTISLPWFAFINVSFALIILLRRVLFNDLTPPWLNEKSLIHSIDISATGILLICS
GLLLIPRQKTLPIQVLLVALSLLWSWCSYHFIAYWTLQFAYPLCVLLMLSGVVALYFHTP
SLLAFVIPLWFTTPIASLMLNQQINIHFAVVWCIFSLALYGGRLILLRWFEEAWVQNSYN
NQLINRLDALAHRDPLTGIANRRAMNSILHDAMDNGGSFALIMLDVDFFKRYNDTYGHPA
GDRCLIQVADALQRSTRQSEDVVVRYGGEEFAIILFNATLPEAETVAARVKQELKLAAIP
HQASAVNAFVTVSQGITCSAPAKTAEQIISDADAALYRAKESGRNRWAL
>A0A8G1X431|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. K91|TrEMBL
MSTSSVGVAPSSDRHAGASGQACYLSASDEQAWIAVYQSVDAYTRGQVAAVVGDSLSALV
DAFYSTLLADAEAGPRLSHDIVSSRLHAGMTRWLKGLLCVRDQGDIAVLMATQKKVGEVH
ARVHIPIHLVMAGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRD
ISRGARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFG
LWLQHKGGAMFESAPGLQQITDAVAQLDSVVLPQLMRGEEQGLAASMPDHVRELQELVAR
IKHLLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREISIARRQRSAFSVLLLDIDHFK
AINDQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAQQEAALATAEKLG
AEIRRHVFNIPEAGPLHITASIGVATFDGHPDYAYLIDRADQALYQAKQAGRDRAVAA
>A0A378KK85|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MDNLDQYKAKLLESTNDVVIITDNNLENPVIKYVNKAFEKLTGFTKEEAIGQTPRILQGP
KTDKNTLRRIKRAMAIKKPVNYELLNYSKNGREYWLEFSVIPLLNERGEVSYFGAIERDI
TQQKYLHNNLYEMATKDYLTGAINRNRFYEVAAISFASYLRGNFNIAIMVIDIDNFKFIN
DTYGHKEGDEQLKLVTSVCFNNIRQTDYLCRFGGDEFIVMIHGLDDKTLKNKADTIINAI
SKSQKSKVSVSIGATLVDIKDTNIDDLIARADLALYEAKKKRKGKAIVF
>D2AGY6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRILNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSFLS
QKRLVKSKILGAGSSRKLAVS
>A0A173YYY9|diguanylate cyclase|EC 2.7.7.65|Clostridium disporicum|TrEMBL
MYKRKNTNNVKVKMNEKVIIAIVFICFILTLTFSVISFYKSKQNQVGIIEKSLEDHGNQC
KESIEEYFEYSFKILNYLANNENIYNMNWDEQYSFLKGQETLLNFEHFIIMDMLGNGYYV
NRNEVKDQSHEDFFHDVIDNERFVTEPFMEVHQNRSITTLSVSIYKDKKKVGALCGVIDL
NKIYNIFKNKVVGKSGYSFLINNNGDYVAHKDMQFVHDSKNIFEDFEGKSNNIDFLREGI
NKGETSLGKVKLNGETYYANFNPLDSVKWNAVFLIPKDEVLSGFNKFVIFQLLALTSGFL
LIIFGVRIIYKNIENHRLAYTDGLTNTNNRAAVDIKFKELDNKYKSNIIIVSFDLNNFKY
VNDNFGHHIGDELLIKFAGILQETLGSIGFVGRMGGDEFIAILNNIDIEVIKSKIDDMKE
KIEDYNYNKICKLEISYGYFNRGNGDKRPLIEIYKEADKKMYVFKKQIKSI
>A0A7W2XC69|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00901|TrEMBL
MMNDENFYNKESIREEWHQNLSQDDSHRTGIRFARRVRLARMVGLAAMFFPIAGVLVTQF
LAGGWWLLLVGWAFVWPHLAWQITCRAPDPFRREIVNLKVDAVIAGVWIGLMGGNALPTT
ALVMMIGMNMMGSGGCRLFLAGVTMTLLSAVVTLSLTGRIVTFSPEPLEWWLTLPVFMLY
PMLFAWVSHQTAVRLAENRHRLELMSTHDGMTGVFNRRHWETLLRNEYEQCRHNHRQTTI
LLIDIDHFKGINDTWGHDVGDEAIIAITRQLQMTLRSGDFIGRFGGDEFAIIMSGTPAEN
AIAAMSRVHERLKKLSLPGAPSERLRISVGVAPWSTQFGHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A482PJQ7|diguanylate cyclase|EC 2.7.7.65|Citrobacter rodentium|TrEMBL
MDKDLSRTTRPTFKRALRRINMISVLVTMTLIWVLLCVASVLTLKQYAQKNLELTAATMT
HSLEAALVFADDAAATETLAALGRQGQFSAAVVRDKNENVIAAWRYNAQQTDDKLNGYIS
RWLFPLPVTQPVWHNGDIIGEVCLTARDSLIGHFIWLSLAVLTGSILLAAGIAILLTRHL
HSGVVAALQNITDVVHDVRTNRNFSRRVSEERIEEFHRFAQDFNSLLDEMEEWQLRLQAR
NTQLLRTALHDPLTGLANRAAFRSSINALMNDDAARSSSALLFLDGDNFKFVNDTWGHAA
GDRVLIEVAKRLAEFGGSRHQPYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFDRPFDL
HNGHLASMTLSIGYALTWEHASAEKLQELADRNMYQAKHQRAERLIK
>A0A0H3EIA9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O83:H1 (strain NRG 857C / AIEC)|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A727RPJ0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Javiana|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQVWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6P1PY59|diguanylate cyclase|EC 2.7.7.65|Mixta intestinalis|TrEMBL
MALDVYTLFICELYVLGFLSIMMLFAWSGAQYDRVLGFTAVAIMATMTAVWLSSLRDQGQ
IFLAVAVGNTLVMLGYGMLLCAFRVFAGQRPGFSWLFGALLWALLCCFPSFYHSMPKRIM
VSCLLCISYTAALIVPLIRTRATLQITFWPAQLLLWFHLGFHLTRMCFDSGTPSHSHGAT
GDTPFSSLVILESILFVIGLTFTILAMVNERTQIRYKQASLRDPLTGVWNRRALFAQARK
AEKRSVQQQMMLAALVFDLDHFKSINDRFGHGQGDRVLLDFCRIVTSVLPMESTFSRLGG
EEFAAFFCGDVEKAQRLCEEIRLLVMISRPDNIEYTVSVGIAAGHPPHTFSSLMTAADEA
LYQAKAGGRNRTETLVPAPLTTALATEKN
>A0A8E6J5W0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A8F9Z5N7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Minnesota|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5P9J074|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MFNKHSLILRLAIALVLTSLIVGVIAVKYYYRSVYQQEVEKANLAIAQLHMTVSSTASIA
AYLQDEDLAIEVISGLLKNDSILAAQIQGTQPLASQGEGDWQQAKTFTLYNPFFANEAVG
QMRLLPAWSMIEQRARSIAQSSAQLLVFQTLAVLLTFTVLAYFIITKPMTRLNTQLKGIT
PSGDNRLHIPFAHNASEIGEITHSINAMLAQTERLFNQERALRSEVQKLEGRLRLLFEHA
ASAMILARREGNIILYNASTERLFNRLGIPLEKDLYQLVARTFNEPEKIIRSIRNSLDQH
DIATGEYQLCTDCQQDCIWAHILVTRSYGKEQDTYLQIFINDITRHKKMVAELNEAATTD
RLTGLFNRLGGEQAAQQRLDNDQDITLMLIDLDGFKPINDVYGHDAGDDILCHVATQLQH
HVRKEDVCIRWGGDEFVIILDALEQTPALHLADKLREALSQATRLDNGEQVSVGASIGIA
TSPEHGTTLQDLVIAADQAMYKVKNQQKNAVAMADI
>A0A6I2IBE0|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT714|TrEMBL
MQRDTLKTKKNYLERLRRHPGRIVNLCFLVVLIFSTILTWREVVVLEEAYISSQQNHLEN
VANALDRQLQFSVDKLLFFRHSMGDALQTPLGFRVLHDAVSDFTRLRTEPFWQLDVDQQR
TLAIYGVSDALVERTTLLARDNERIGKELSAALELGYLLRLATSTSGKEKGVSYVSRAGF
FLSTQASAQHQTVVSRYYHFVTQPWFTRQTERENRGRSVRWFIASPSGVDEERTITASVP
VYLDHYWYGVLAMDFTLTTMKNLLTDAVDVHTDGEYQLYDSRLNRIASSESADDAINLFD
ENERAQIAHAIERDTEGGIRLNTRYVSWERLDHFDGVVLRVHTLEEGVHGQFGSISVALA
LLWALFTAMLLISWLVIRRMVSNMYTLQNSLKWQAWHDPLTRLNNRGAFFDRAKALAQKC
HQQKIPFSVIQLDLDHFKNINDRYGHQAGDKVLSHTAGLIARALRSSDVAGRVGGEEFCV
ALPGATAEQAVIVAERIRASVNSKEILILKSTTTRVTASLGVSSSEESDNADFEQLQSIA
DARLYQAKQQGRNQVVCREPDKK
>A0A6I2I9A5|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT714|TrEMBL
MNKEFTSMPRPTFKRTLRRISMISVIITMTIVWLLLCIASVVTLKQYAQKNLELTSATMS
RSLEASLVFNDATAATETLATLGKQGQFAVAEVFDIHQKRFAYWSWNPDENPDTLGTLVS
RLLFPVPAAQPVMHNGAVIGEVRITARDSLISHFIWTSFAVLTGCILFASFVALAITHSL
HHGIVTALQNITDVVHDVRTNRNFSRRVEEERIEEFHRFGQDFNSLLDEMEEWQLKLQAR
NAQLMRTAMHDPLTGLANRAAFRNSIAALMKDPSAQTNSALLFLDGDNFKAINDTWGHAA
GDCVLIEVASRMVEFGAKRHQSYRLGGDEFAMILYGVHSGADVQQICAALSQQLIRPYDL
HNGHRVKMSLSIGFALTWETTSVDMLLEQADRNMYLVKNQRSKTIS
>A0A1Y6M9V5|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MAGLNKWLRSIVLFLVFFTIVAYGWYLLGGAQKEYIVTPQNSQYKIIDDSVQSGATKATL
DISKDSVFLECDIINKAKWPFCEIAISLTNYIDKGIDLSTYHSVGIDIDYTSPLEDERVR
VYLRNFDSTYANVNDPISLKFNAIEYSPGVDDGLKIFPLRNFQVLSWWIAENNIPVDKSS
RQFDNISVIEIATGSYVKESYYAIRLNRLVFYGEWISESSLVKALLLLWVVTAIIIIMSE
RFILDKRIKHTEERSQRLRDANRLLYNKSLKFEHLACTDPLTRIRNRHTVTEWLEEITIQ
TQSNDIPFSMIFIDIDHFKAVNDTYGHGFGDTVLVKFAETIDKLIRRSDMFARWGGEEFV
LFCPETNMSTAVEIAEEIRETIANKVWDFDHEFKLTCSLGIAELVNESSEELIQRADLAL
LKAKKMGRNRIEISWEHQQLR
>A0A8B3ZN14|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLSLNGVSDAFVSQTQLLSRDDQTLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A087DAW6|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium saguini DSM 23967|TrEMBL
MVTMVSEIFAPTRTGTYPRKATMTRILIVEDEESYREPLVYQLTREGYDVSAAATGEEGL
ELFTKGGIDLVLLDLMLPGIDGTALCRRIREQSRVPIIMLTAKSAEIDKVVGLEIGADDY
VTKPYSFRELLARIRAVLRRNQATAQAAGSVDDDIPLVCGDISMQVGQHQVTVRGETVFF
PLKEFELLEYLMQNKGRVMTRHQLIDRIWGSDYVGDTKTLDVHVKRVRSKIEEDPAHPKY
LTTVRGLGYKIDTPAE
>A0A379CSB3|diguanylate cyclase|EC 2.7.7.65|Plesiomonas shigelloides|TrEMBL
MEKRKPRAFWQVWRWTFFVFILLFFVDVSAFYELSRQNKIEQQRFFAAEARAYVAKVRGS
IKTDLQLLTSLSLGFRLNNYVPLRDIQAYIESMRLSAPQTVKLEWFPLVTQDQVAPFLQQ
MRNIYPAYHYQGWLFSDNTPLDTLLAQPYIFPLAFVYPASEQNQQYLGLLFGGEKRDSYL
ADIIAGAEQIITDPIRLWNQQSKNNNRKNGFLVINAVRNIRDKSLDGIFVSVINSYAYFS
HVINTINPRPGMAIQISDVSSSPEIVLYHSAAAVAAPRSAGPLMQHVEYIAQGDRHWKVS
VTGHWALYAENRLLLKILWWGGLVVSLLVSLIVGYAVNRTGLYEFLLQQRTRELEFMLEH
DHLTRVLNRRAYDRLLGEFCQSTRPFTLFMIDMDYFKRINDCFGHAAGDAALIEVALRLQ
QAAGSGTYLARIGGDEFALMTPVTQSDAVQSLGERMLLAVREPVFSFRQQAIHLSITLGA
AVYQAGQNPDQIQDCADQALYAAKQRGRGCCVQYVQYMNGRAP
>A0A447JP33|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Daytona|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCMPMIGIVVLSVLLLIW
HGKYGQKRINLPFISLLFGGIWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLYSLPPVSVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNGLSMLDPLTGLYNRRGLQNRLDTLQAPGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDMRAL
>A0A447JH75|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Daytona|TrEMBL
MISLVDCAFRCPFDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMT
GLYNRKILTPVLEQRLQRLVNTGTPVTFVAIDCDRLKLINDTQGHQEGDRIITLLAKAIK
TSIRKSDYAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQP
NDTINDAYQASDAQLYLNKQQKTTSFIIVLRSKCSYCTRSEKWPK
>A0A8G0FKJ4|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIIGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>Q9ZA91|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEFFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRILKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPSYTTQWTEIPI
ASF
>A0A447WAK9|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSSERRRSRDGAA
>A0A447WCH4|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQ
>A0A658XZY8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFLGGR
>A0A8H0XCZ5|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E4694|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVVEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENELLDNEITAALEVGYLLRLAHNSTSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHGHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKKLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSL
>A0A212KK83|diguanylate cyclase|EC 2.7.7.65|uncultured Desulfovibrio sp|TrEMBL
MVSFASTGFHLFRFLGVDAFCRCGVHMTDSQPNLRSESERSKSSRLHSHKQLWVIATINL
LVLGIIIFALVGSRQQELDKAANTLESVSRSIDDVLSWRFEKINLALLGAVDEAQQQALR
GDVSWECFEAYGKNLDERLPDTLGFLLTNTQGRVVYASPRALSGEMSITNTDHFVQLRNN
PSSGLVISHPFYSQLWTRPIIVLSMRYLLPDGSFGGVVACAVSIDMFSDIMASAVIVGSS
AVATLWDKKLGLVTQYPRGRFWLDAKPSPPLRKLIEHDAAPSIYQHRRADFGDKKRIAFY
RKLSQWPLYLSIGLYEQAVLAKWRQDIFSLVFLWVVCVFISFWSGISYTRQLKALELGEK
RYKGLFDNMQAGMALCEPVFAPDGKICDFRLVEINQAYCDVFKAEREDVIGKTLLERISP
KTSETARWVNPLIVTAETGDPSHFEFYLAGNNLWADIVAYRSEVGIIAFLCTDISERKFA
QARANRISQMYAALSRCNQAIVRCSGRNDLFAEVCRAAVEAGGMKGAWIGLVEKQTGNVQ
PVASFGLSNTDLQKLDISVWASDPKGSGPTGCAIRNNESVWSDDTTTDPRLAPWWQLVRK
TGFLSVGALPLRQRGEVVGNLTLYADDAGTFDAEVRELLGEMALNVSFALDNFTWEEERR
RNEARINELAYYDQLTGLANRPLLTDRIRQAVAVGMRTDKFSALLFIDLDRFKTINDTLG
HAHGDNLLKQVGQRLLAIVPADDTVARFGGDEFVLLLHGLSGNSEEAAEAVALICRKILN
AVREPILVEGITCNCTASIGVALFGKQSITPDELLKQADLAMYQAKDAGRNTVRFFDPAM
QQTVMERIELERDLEEAIRLEQFVLYYQPLIDLDDNVFGAEALIRWQHPKRGIVSPADFI
PLAEENGMIARIGAWVVRQACSQLGRWAVMPEFSNLTIAINVSARQFRESDFVRDVTAAV
RQTGIDPSLLKLELTESQLAVNMQEIISSMVELSNLGIRFSLDDFGTGYSSMAYLKLLPL
DQLKIDRSFIRDLLTDPNDAAIASIIIALSQSLGLTTVAEGVETREQKRALLNMGCTLFQ
GYLFSVPLAVKDFERYLARRNAAAAAEGHGNRAEQPESAEQTESAEQVAEGEGRGAA
>A0A4R8R401|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MEVADRRSSERGETNNLVIESRPVDIDRQGRRHGVTYRFLTMALETTRNTARLKIAIGVL
CMSMTVLSVIVQFNPLGPQGLWPRAIHGIVAGSALLVGLAWIVRPWPSRPWAIAFVFWAD
TATAVGASMCSQPASQLGATNHLALIGIFAAFLLGWRVLAAHCVFATAVITALTLWNLHS
GAATLSELYVYNAPAYSNVVFLPIVIQAVIEGVRKSIRRNAIAAHSDPLTGLLNRRGVQS
AMRARLCREPRPAVVAVFVVDIDHFKEVNDAYGHDVGDSTLKRVADTLAAGIRQRDIAAR
IGGDEFMVVAFLDRSEDVDTVLGRICDAPLKTAEPMVSISVGSAWQYTYNEDFTFESLSR
EADFSLYEAKRARQSHNGTRACTCYPGYPGAQGQCDTNTCDTSTPRR
>A0A379LSC4|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MNYYTPDDIQLKRRSTRFVRRMFMMRQLGTFLCFLPIMSVLMEMGKSLELCALLFTNAFV
WPYAAFRLALRSRDPTGFERKNLTLDAAFGGFWVATMALSPLPSIIIMAVLISDRYSAGG
WVQLKSALQAFLLTFLLAWLAEKAPLQLTFSTRTVWLTLPLASGYLLALSVVSHNLTLSL
RKKNQELERIALMDPGLKIPNRRLFERRLESEFLRTQRGEGKAWLMLLDVDHFKQVNDTF
GHEAGDFLLAEISALLRDSVGLKDIPARFGGDELCVIVRDADETSIMLLAEQIRQGDCPA
AAAGVIHLSVLGEYRDCTGMRCGDNS
>A0A5E4SDQ8|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MKSTISRTEQGNRVAATVILMACAALTLTGFLARAIQGEVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTHAPFWLWLMAEA
SFAAYVMLSVRSYSRTRSDPHIRPGYKEAARYGATVLVIWATTSLALVGTGRTLATPPLP
GGGVETLALYALFVAYVVLWWRVAAVTRLSHKLFLLVWVVVTISLCELLLSLTAPSDASY
QWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFVDPLTHIYNRRYFDNRI
RLVADRVQQRAIPLSLLLIDIDFFKQVNDRYGHPFGDAVLQRIATTIQHCIRLPSDFAVR
LGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDMLPEKARDKGEAITISVGIATWQPG
EPLVISAMLERADKALYQAKHKGRDQSVLGQLAA
>A0A6N3DSI0|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MTSQSWRSLVQRKYQLSLRLFLFLNATSAVFSVTNPLYSVRVFSAPLIAIFSISTGLFVW
HWKKCARKINIPFVSGIFGILWAWQIDSKFSLITHNQATYLLIALLTVLFIGTLAFASNI
KAFTLHSLPAFIVCLWLSEPEMWLRMTYSFALPVVAIAIHNILQRRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPAVENGEHFVLLMDIDHFKAYNDHYGHMMG
DQALKRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARHTAERIRQKVYDLKIPHL
FNESVATNVTISIGIAIFENEDVEGALERADRALYEAKHLGRNNILLSEELQTA
>A0A1C3JKW5|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MEQQFLLEGHRAVNSLLRKLALGMDRKDLNHKIIQLTEQLFGQRMASILLLNSESKTLHL
EYAPNLPDFYNQQIEGIGIGAGIGSCGEAAALKKAVMVSNINAHPNWAPFLVLTNQANLH
ACWSVPIISSRGNVLGTFAIYSQYISEPHEFELEILELLASLYSVALEKFELENQLNFFA
NRDSLTHCLNRRALFNEAEKVLAKRCFSEKVMACLFVDVDKFKSINDTYGHSFGDDVLLA
VAEVLDEATTACAKIGRYGGDEFVVFSCFDDQESVVSFYHSLEKALQQALYINDVQFSVS
VGLSCDKDPQGLDQLIAQADKNMYQIKQAKSQQ
>A0A1X3I5M2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli M056|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8F9C0Y4|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MPARPSMFNFLLDTPASGNGQVTASIRASLLSTLFENTRPLLMSGLSSAFVAVVACFRVH
HAWAPLWLAAEILFLAARMTIAHLYVARNRVRPVHPEPSAARYAPVSLLACLTFGLGTMA
SIISGDMELASLSLMVTAGILGGIASRNAALPRLAIMQIFFGTIPIGVGALLAPRSASWI
LVPPLFAYLVAMVSVVRRHYEGLVALMTAEQRHAELAARFDAALTHMPHGLCTIDGNGRV
IVANRRAAELFGATVEMLRLNVPLPEFIGQVGVAKFGETLRKQLVERCTTWLSGERRPLD
LDLGDGRQLEMTRNPVPDGSAVIIIEDVTERRQSEAKILHLARHDPLTGLPNRRDLYERL
ERILARSMGGREPEVALMYLDLDGFKQVNDRLGHHAGDEVLTAVAGRLKELLWTGEFVAR
LGGDEFAVVVENSTCAASEALAPRIIRELAKPYMLSTGEAISIGTSIGIAFAVHGESIEQ
LLKRADVALYDAKEAGKGTFRFSVPDSSRKEGAVSEPRWPAV
>G9Z8K6|diguanylate cyclase|EC 2.7.7.65|Yokenella regensburgei ATCC 43003|TrEMBL
MLYVSRAGFFLSSNPDENPKSVIMAYYGLVTSPWFAQQSQRNNPARGIRWYTQPAPKGES
IEASLVTASLPLDFKHYWYGVLAMDFSVSEMKNFLLRAVEGEEEGEYQLYDSKMNLIASS
AVGADIIHLDKLEEAQLANDFEHDNRGGLRLVTRYISWEKLRNFDGVLLRIHSLNEGIRG
DFGTITIALALVWLLFTSMLLFSWWLIRSMVANMTGLQESLQWRAWHDALTRLYNRGALF
ERAVTATQECEEKLLPISVIQLDLDYFKQINDKYGHQAGDRVLSHAASLITSKIREADIA
GRVGGEEFCVVLPGASLRTAMEAAERIRERIHSRELLVGKGATQRISASLGVSSSDETGQ
YDFEVLQSIADKRLYQAKQNGRNQTCGADDS
>A0A238DSD2|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MTDPRESSNHGRQPCSAANRARAGFMAKNGSTSLACFSAGTHACMDANAAFASLFGMQED
ALVGRHLSRIFAPECVAQIEPFMHDALEDRQEQLFELSLRDAVGSVRDFDVSLLPYTPGG
AVLELCMVMHEVTRFRAMARMAHEAAARLHRFMDASTEGIVFQRDGVIVDMNPALARLMG
YVGQDIIGLRAIDFVSPDYRDIVIGKFHSKVENSPYEVTLLHREGYDIPVELVSSNVEFD
GEMLRMTLVRDIRARRAAERRMRELAERDGLTGLYNRRMFLEQLPARIAGLSEREQTAAL
LFIDLDRFKQVNDRHGHAQGDRLLQTVGRELLAFLTPGDIAGRMGGDEFAVLLTGVQPEA
AGHRAQALLARLQAAFDTTGLTEMAYASIGVALFPNHGQTADTLRRQADQAMYLAKAQGG
NAVRLYAPAG
>A0A8G0CWY9|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAVAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSQAFDPRTRPWFIKQAEASTFSHYTSPYMDFFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSNELMD
KMTSGEGQLYDPGSNTWYYYYSFTNPDWFVIFRVDNTTLVNLTRHETNLVIGGFALAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSIDEALYKAKQQGKNRILRA
>A0A7Z7RIZ6|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MPSPIIPSILDFKTTLLSTTGYTAMLTLVVLMFWLYNRNERALLTLGIAGCIAACGTLIA
YLPLPIPAWPNLVLDTFLLLLYHPLAVVATRQLLGLRNDWRFHLAMLIIIMLCFVFWAGP
GSYTRRVEVTACAHILYWSMIVAQLYRGRQWRTMMGYRLGLGLAALTIGVALFRLAMSWL
EKGSNFSSANQLLVMFTSLSLFWLTFCYSLSLLFISYERLLLQVRQQAQQDGLTQLYNHR
TFHEQAAAMFSRSRQRGQALALLLIDLDHFKEVNDRYGHQVGMRYCASWPTVCGRSRARA
TCWDATAARSSW
>A0A380WFE0|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MTGAEFILAINVFVAGLLAGAFMSIAIYDGRRNSARWFALCYLTGIVYIGTEFAIPMFAD
TQFIVTANFVAFLATLMFMNVGLAIRYEAQPAWRLMAAFLVVTTIAVFATQGFARDSLLR
MMTYQTPYAIAQAVGAATILRSRRQLSQFDYVLAGVLFASALQFFSKPYLALAVGGPGSD
PHHYLQSTYAMVSQALGTVFALSIALMLLVILVRDILLDATQKSETDALSGLLNRGGFQR
RAASAMRDAVRQGLPITLVISDLDHFKSINDSYGHASGDRVIEAFAQFIRESMAGHHVAG
RIGGEEFAIILPGAHLASARLFAEGARSAFSGMPIDGLPADCRFTASFGVAELVAGESID
QLMVRADSALYEAKKDGRDCVRVWGAVQPFSDSTVVSFALKPPSR
>A0A7W8T9P1|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. MM5384-R2|TrEMBL
MDTSKPPQNAATLHPADDANAQAHALVAEDAPSLASDDALARIFADPPAAECPIMVLLVG
DQAVIAEGVREALADEPGIDFRYCASWEVAVRCAEETRATVILQDLVMPGTDGLTLVRQY
RLNAATRDIPIVVLSTNEEPLVKSAAFAAGSSDYLVKLPDRIELIARIRYHSRSYLHLLQ
RDEAYRALRQSQRQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWHRGTRDKTGLGL
LMIDVDHFKAYNDTYGHVAGDEVLKSVAHTIEACLGHSLDLAARFGGEEFAVVVPDASAG
GLRLLAEKIRIAVEDRAITHAGSAEGVVTISIGAAMVVPSAAEPVTTLIEAAGVGLYRAK
HDGKNQVAVSG
>A0A1J5T145|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNVLRKGWRATGVQGKLHILIQGALMILFFVLLEQATDRFEKQIERSAESRAQDTADGLI
NGMNMLMLTGQISNPDNRKLLLNKMSQLRGVAELRIIRGRAVVEQFGPGLPTEAAIDDMD
REVLNTGKTLFRKMESRNGHPALRVMVPFIAQKNFRGTNCLACHHTPDGGVNGAASVTID
LSEEESQLAEIKVELWVGLVVMQLLLLLIISMFVRVVIVRNITRPIKRLQAAMAEIRSDM
DLSRRADVGEDNPDIGEMAQNFNRLVEKLEHANERLQLFVKMFDNSSEAILITDAQRRIV
AVNPAFCKITEYAEEEVIGKNPRILSSGRQDAKFYESMWNTINETGLWQGEIWNRRKSGE
LYPEWLSIGTVKNAQNETINYIALFSDITKRKEAEARIEHLAHYDSLTHLPNRALFAERL
KHALVTGVRNKKKTGLLFLDLDKFKFVNDTMGHLAGDLLLSSVARRLQSCVRESDTICRQ
GGDEFMILLPEIGMAEDAEKVARKIVAAMGQPHQIEGRELIITFSIGISICPDDASDDET
MIRHADDAMYAAKESGRNNYRFFA
>A0A1J5Q1T3|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPSFITNLMNLRSVLARWQADHDGIADAATTVNLKHLRWIAPVGAVINALHVLVLGTQYF
SGAYQGVTLAWRTGLLIAHFIMGLTMIVFTIAVRQVDPTRPKYWDRQLPVGAVAVCLLFA
VAIVTIDQLVTVNITPFLVGCLAMGVLFYVKPLQSGVLYLTATVGYFLCIGLTQNNLEQL
LSNRLNGITIGILGWVLQFVMWRNFTTITCQQHLLAQTNAKLTDRQAELERLVRDDVLTG
LPNRLAANERLHTEFVSMKRSNEGYAVLMMDIDFFKRVNDTHGHAVGDQVLQSVAKTIQV
TLRESDFAARFGGEEFLALLPFTDLPAALRVAEKLRQAVESSADPVTGRITLSIGLSLAT
PDQASKDVAVREADDALYCAKRGGRNRVQVASESLEQAEPGDTATAKLLQLVWHATYESG
DQTIDTQHRALFRHANKLLQAALDGCPQQELVALVKAFIAEVAQHFRDEEAIIIQAGYPG
AVDHASLHRALIEKATDLTQRVSAGNLGVSELFMYLVHDMVKRHMLTADRKFFPYLQTGH
>A0A1J5PIK9|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MQDITALKRLQQQLSEDEQRFRFLAEESPVPLVITRVSDAALLFSNKAADVLFRGSYAEH
PGRSMRNLWVDAAACDQLVDRLQREGTVRGMEQQFRRFDGSVVWLLLSVTRGRYREDDAL
IFALKDITEAKERETELRTLAYTDVLTGIPNRRYFLARAALELRKAKRQGSPLSVLALDI
DRFKQVNDRLGHQGGDAVIRCFAQTCMQQLRGEDVCGRLGGDEFAILLPETNRAVAFDVA
QRLRLAIQEANCLSASSGAVATLTTSIGIAEHLPLSGEIDIDELLDHADQALYRAKQAGR
NKVEIWTGQNPEPV
>A0A1J5RC87|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MQLDVLTSALMAIYAFLPFIILAGLGIFPLTVLESMAFALPVLIAELAAGILGFTMLSLG
QTIGSVWLSLMLAVVATLCGMSQLEFIIQLVRQAIRDGLTGSFTRASGEELLGLQFITTA
RSGTPLSIAFVDLDNFKQINDAYGHEVGDQALICASSSLRTAIRSGDMLVRWGGEEFVVI
LPGATREEARQIMDRLLAGGLGQRPDGSRLTASVGVAERMQDQTDSSRQLVGLADQRMYQ
AKMQGKNRMVFH
>A0A1W1H704|diguanylate cyclase|EC 2.7.7.65|Desulfamplus magnetovallimortis|TrEMBL
MNSQKGILDNSSSERRNRNKGGNILIVDDNPQNLRLLLSILNSEGYKVRPAPSGPMALEA
AFSNVPDLILLDIMMPEMDGFEVCRKLKENEKTSSVPVIFISAMDDIAEKLKGFELGAVD
YITKPFQPREISARVNTHLSLRRVQKLLEYEIVMRTVSENTLKVLSKKYDLILAAAGEGI
LGIDNDCRYTFVNPAAAKMLGCKVDDLVGKSSIPNWYSEKVTREKNYGEDTTECPRPLYK
TLREGAHIRVNHWNLWRQDGTSFDAELICTPIMDENEIEGAVVIFSDISERKRMEKELKL
LATTDSLTGVSNRRFFMEGVSKEINLAMRHDLPVTFLMMDIDEFKNINDTYGHQAGDDIL
KNVSQICMESLRANDLFGRVGGEEFAALLPATSIDQAKVVAERIRKTIEESRWNIGGVTI
SSSISIGMAPFRRDKEGGVDALIKDADEALYYAKNSGRNCIKISE
>A0A1J5TEK4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTRYSVERFRAAVFHMYLRVAVAVTFPLSILYFLFVATPDRGAVPFVFALFAMWLKWRTR
HDSEESLRYAGCFVLTLMCLMLYGAYVSNEKLHQEVWMMIFPIAFAPIVAERERITWIAV
GALSLFAVSMLRLEPLTLISAFVFLSAYLTLGLITMMLVRHNEQNIERLAHLTITDPLTK
TYNRGYLKEVMASEINRCKRSGQALTVIMLDIDYFKMFNDTYGHLYGDSVLEQVAESLKK
SAQRAGDYVFRYGGEEFCILASGLDREEAGQFTEKLRLSIYGLNIENRQSPHHRLTASAG
FWCVAELSEITTSALLLNADNALYRAKEAGRDRVVDFDEIPPAEITRSTQLQSAPA
>A0A1J5Q734|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLDKAVDKPQVAARVGGDEFVLLLPDTDAKEAVRMRERVQKLVDLNNQFYQSPPLSFSMG
VATCLPGERLEAAIGRADQQMYAEKRAHYLQETENRRLD
>A0A1J5QDY2|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNAPPPAEHAAPRADSAADNVRTLLAAAPMAATGSMFAALAVSWLLRAQVAPARLAAWVL
ALALVHAARLALARHGRRHLRDETALAALRPALRASALAQGLCWAALPALLWPPSVSAQL
FIGIVIASIGGSAMVELAADMLAAAAFIVPPTLALVVQYAQSPEPLLRAMSVLGVANTSY
LLLASYRTHRMVSRVARQRAHATERALVDALTALPNRAGFRARLAEALARAQRHGRPLAL
AYLDLNDFKPVNDRHGHAAGDAVLCEVAQRWRDACRGGDVVARIGGDEFALLLADVAGID
DAAQALTRLRAALEAPCTLPGGGSARIGVTIGLAWARAEDDPDSLMQRADHAMYLGKQHK
DDPRGWWESAA
>A0A378RE47|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MVRDALRRWWQQSTHYEWLSGYLADRGMRGPARALMAFLAVSMIACLLGMLHSPDGPIGT
VPRAMTWLAIVGGVAGAALFTVKWPTRRESVLFVFITNASMTLACVANPSPLHTLVGCIS
FATIGAYIAFFHTTALVLYNFSVAATVATWGAVRMAADGQLIIAGVDWWLIIQVNIALPL
AIQILVNALGVDLLRAERDPLTGLLNRRLFHSQTFGLIESGRHAGAHLAVALVDLDKFKS
VNDRYGHAAGDEALVHVARAIEQAAGAEAVVARSGGEEFVVAAALPSADCNELAQRICTA
IAESPAGVTASIGTTAVRLSDTYGDHKVLLDRLVSNADWAMYRAKRAGGNGCRHQDTDPV
DRRRPDVDGDANQSIA
>A0A1C5XXY2|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKKQTQIREYAKIMSVFLVAVVIGLLIFFYCIQRSVEHRSQKMMMNNVSRQSVHLRTIL
NIQYAYLDGLAEEIGKSDQLLDQKNINLLQSVTKNTDFGATALIEPDGTSHYSNGQTKDV
SHRRYYREAMSGKRTLSEPLDSSISGSTRVVLGVPIYKDKKVIGILGGSYDVTALSRMLF
EDLFDGEGCSMIIAQSGEVIAFEGDTSYWNIDYRDNFYTYCKKLMIKDNVTAKMIKQDFY
KGKSNLVTADSKKKGNVRHYFAYMPMKINNWTLCYAVPEKTAQQSYDFIEHYEIIFMAVF
VILVILLVLYIVHENYRRNQELMKYAQTDALTGLYNKETTKLLTDEILSTDRDMIHAFLI
LDMDCFKQINDGYGHAVGDIVLQKFGQLLRDIFREDDIVGRIGGDEFVVVMKNIKMKEMA
IAKAEELLTKTQQYEIKELNGSAISISIGIAMAPEDGDCYMDLYKRADQALYQAKRSGKA
RVCGY
>A0A1E3KYX7|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MITIIQSLLNNLTFLTTTLFFGNLILKWLSKRIDIHSLYVKLVSGIFAGVIGIMLTKYFS
FRLSDMIVLDLRQVAIILSFYFGGALSSLVTAVIIGVYRLFLIDPINFSSFIGFFNAIFT
FIVTGFFIKKGKELVLSQWVRMMFGILLVYGLSVFSVLGEKAFFTIIIFSLFYIPAVLFV
YYLLRYMKRTDDALLLMREAVNLDFLTGLHNPRAFEKMFEQKTMNIAYQAQPFSLLMFDL
DHFKQVNDTYGHLNGDVILIQVAQLLKMTMRSNDYCARKGGEEFAAILNDCTIEKTLKIA
ESIRKKVEVHPFELEDGQIIQVTISIGISCYPQDQPENMFEQADRALYVAKSSGRNQVKL
AEPLK
>A0A1E3AD00|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MITEKRLKKQITIAAVTAAGIFAALAVTAIMAFITLSRAQKNEAEIYLNEVTEQYKSTIV
TQMEGYLHVLEALSTILGEKEMEEDEILDILEIENYQNDFIRMGFVGTDGIGELVDMDGV
RYENVRLGEEEFIQDAMKGNSVVSNTMRDRFDDGYINCYGVPVYRKGELLGVLTAASEYE
SFGKIISRPIFNGSAYLHIIDSNGDFVIRSGHKLIENEDCQNIFDMDLLGAGIEENLLSQ
LKTGETFFSGFTRNNTKFWVFFAPIERNGWYLVCMIPQKALNANFNRMTRVAIAVFSIII
LLLVILFAYIYMLIRNNRNEMRRLAYYDPLTGLYNKARFVEEAMSLLKQKSDYALVLLDV
VNFKFVNELFGYEKGDVLLRHVAQVCMNAIDSAELCCRDNSDKFALLMSYGEKQALTDRL
TKIMESISRCQLDPVQEYRILCNCGVKTVENYNGRVDFDVFWDRADLALKNAKGNQNDAI
IFMVKNCMKGK
>A0A6N2ZFR3|diguanylate cyclase|EC 2.7.7.65|Eggerthella lenta|TrEMBL
MSPADESGAFVGYTYEYFERLAQYTGWSYEFVPVEGSGPAAYKTLRDLLGAGDADVAVGL
MATQEGRESLAFTRDSFAALNVVLRTAAEVSDDPLDEATSDHPLRVAVIEGSPLASDLEA
FCAQNEIPYETVGFADAGEARDAVLNGRVDVELAADMSDTTGLRTVVHMTTHPLYFAVAL
DNRALAGELDDALDRIDQVDPLFRARLRDRHFSVASPVFLLTDVEKSFVEGAAPVRVGVL
SDQPPYQYQEDGQVKGIAVDILETVAQKTGLRFEYVAAETVEALDTLQAAGSIDMVAGID
RDYSTANERNLALTQPYVSASYVLVANKSVADGAISGKRLAISSSSSYDGGFLGDAIQFP
SIASCLRAVFKGEADYTYVDEYMTQYFLNTPEFRDVRIAPQTYEPRRVSLGVVRSDDTTL
LGIVDRAVGSLTEVERQAVINGNVLRERPVDLGELVHANPAIALAVASATCLIVVLFVLI
ILGLRARSNAKTAFDLKKRLRLYALCDDSFFEFDCRTKRLIISMPGKGQQGLSEPFAFEC
DAPAVFDEERKRSFAELLGGKEHRVEEVRMPDTDGIEHWLRVTVDPVEDASGRVAHTVGK
IEVIDEERREKDQLVARAERDSLTGLLNSETTRLRIGQQLDALAGGERGALLVVDVDCFK
DVNDTHGHLVGDLVLADIARILRENFRIGDVVGRLGGDEFMVYLDRVGSTDVVLGKCDRL
RRAVERHEYPGTDCRATISVGVVLAHAGDTFDDLYGRADEALYAAKRDGRNRCGLADGAL
RSPKAAPAP
>A0A1Y6MIZ7|diguanylate cyclase|EC 2.7.7.65|Photobacterium malacitanum|TrEMBL
MLSVKNFFSNYSMYKKIAFQITAFLFFIFLSFQLLVLFKFFSEDTLNVIHNHSTKINILF
VFTLFFILFYFINVINKWFINPLKKLNKELNEKGNILNDENIHDINISDTFKYCSAIIDE
VNKKDSQVDFETSELTKEKQALMSHNQLTSSIFNNSQDIIIIIDNNGIITRVNPTFCKLI
GVKYENLLHQPLINFINKVAYKNIKASLTHELNRCHHWQGEFTIQHLTNKKTIPLYVKIN
KFIDNKNNHIQYSIIATDLTTIREIDRLVYINHHDSLTELPNRVALTNRLNDELNTQQTK
CHKFAVVFIDLDNFKKINDNYGHQMGDKVLKITAYKLRNSIKKTDMVARLSGDEFIAIIN
PATTQTDVIQACERILNVLQQPIIINKHHIEMSASLGCYYAHPKQHQTIEDILSQADIAM
YKAKMTGKGRIVECNSF
>A0A735JWG3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGELRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3DB59|diguanylate cyclase|EC 2.7.7.65|Eggerthella lenta|TrEMBL
MAEYNDDLNYPDPFYISDIETYELLHVNEAGRRLFKVPLDADLEGVKCYEFLQGRDEPCP
FCTNHLLSVEKSYVWEFTNPLTNHRHLLNDRLINWGGKLVRLEVGFDLTDQKEEGMRFRN
LHRNEEVILEIANDLYRETDPERASVRMLERLGEELGAERSYLFSARGEGFSNTHEWCAD
GISSQIESLQDMDYRLFERWLDLFGRGECVLIEDLDAIKGVVDPREYETLHVQEIASLVV
APIERDGRLVGFLGMDNPPADQIRDIAPLLRTLCYFYSMTLQRIENERQLVAMSYHDSLT
GLYNRNRYNEDVRRLEKLARPFGAVFLDVNGMKEINDRGGHAEGDHLLQACAQTMQRVLG
EVARLYRVGGDEFVATVVDTDEAGFRSLVERLQKAFDEVPSCEVAIGAQWTPRSSEIDRT
LFDADEAMYRDKRRFYQNRSTSDVAPSRRARGDRFDERERAKARDVAQEGTLMELLGIGF
ARHRLDEAFTTLESNACYSLVTGDDEEGRRAVGALAKEAREAGERGFAGTVCVNRGGVPA
RVRVSGAFAEDEAAGGAVALASYVDVEDALASMGKEAYKPSNS
>A0A736KLX1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWLDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3QH23|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A0U0ZWF5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus|TrEMBL
MVTTYPGRNGFGSESNRCSAGVQVYGANNDILERVGLRRPVSRANAVFITAVGAAAILLA
ATGMSTIPLLCISLSIPAFLWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTGVA
FVKLAWLLAVSAYVSLVHGRVAVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTML
LANLFAGLVIYVGKAQFSEHADGRDRLARHDVLTGLLNRRGLQEAYEATVGVPGMHVTVV
VVDLNLFKQINDTFGHHVGDQVLQRTAHRLRSVVGPDALLARLGGDEFGIVVVSDAPPHI
DYQRAVEEALNSASEDVPVSASVGVAAAILPESDRTTIHTLGPIVTHLLVEADGAMYGAK
KAG
>A0A2X0YEG1|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus capsici|TrEMBL
MNAQEFEELWITLNELYNADRFLEYIEISSAAIESAIKLEMYDKAILLLRYSCASYFQTG
DLQLSISVLEQYRELTFQHGNDIDVIQYYNLAAIYWGTFGHLKKSEELMLKGLKIAEAIQ
HVESMGKIYNNLSDLEISMGSYRTAKEFALKSLYYANAFEMKHKEPYTGIIHPKTNLAVA
LIWLEEFEEANTILQELMATIHHPPYSKVQLEVLNAYAFLCERQGRISEAIDLYQKTKHY
ALQNNDLSLLQLIYNSLVKLIEEQGNKIVLCAIQKEYINILLEIQRENYSHVLFEMEYND
HKKQFEKNAYIDPLTNIYNRRYFDEQAKKMVEKATENHQQLALMMVDLDHFKEINDMNGH
LFGDDALTNTAKTLQDYFQPFESIVARFGGDEFIVLSQVKEGESVQTLADNLYQTLTALS
LTVNNQTVQLEFSIGVSTNDHGKIQKVEELIQHADEALYKSKRNGRNQITHYNHYCDVGN
GI
>A0A8B4S2N4|diguanylate cyclase|EC 2.7.7.65|Comamonas testosteroni|TrEMBL
MVATVILGMLCVHLLCFCVLFMLISRRLPRRKMGMEVFALGNLLLGCAYILQLLGGKPGW
SVMSLVNHTLTLCAPVVYVLGAMRFFNRPTPVWRPLLVLALAYSAAQMLVQSTLGPEARH
AMLAAACALLFLCMTITLLWGARSFARNMAVEMMVFAILICGICILNVMKFVLILQGGLQ
ALDMNSRFQMVFYIYMSFLGTVIPPGAVWLALRRLTDELGSMAAQDPLTKLLNRRGLLDG
LEAHFAARKAEPVHLLIVDIDHFKRINDNYGHQFGDNVLCRVAEAIQQSTRRSDLKCRLG
GEEFLVLCPGLKGDEVLQLAERIRAAIAAIALPGISLHGSVTCTATIGISNPFISTQAFD
ITLQQADVALYRGKSAGRNRVQRADPEYLVPRAPESKARRSSLSNRERA
>A0A7Y7YS22|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. P7760|TrEMBL
MNKDLTPSSRPTFKGTLRRISIISVVVAMLIVWLLLSVASMLTLKQYAQKNLELLAVTVS
HSLEAAVVFRDSASANETLSVLGRQGQFTAAKVVDSEGRELTHWQADKPSQHDMVGGLVT
RWLYPHPIRQPIWHNGKIIGEMRLIGTDATVTLFVWLSLGVLTACILLASIIALGISRHL
HGDIDAALQNITDVVHDVRSNRNFSRRVSPEKIEEFHLFALDFNSLLDEMEEWQRQLQLK
NASLQKTALQDPLTGLANRAAFRTALDKLIEDADTLQNSALLFMDGDNFKFINDTWGHAA
GDAVLIEVAKRLLMFANTRHLAFRLGGDEFAMLLHAVCNEGQAAGVLKQLKEIIEQPILL
PGEHWVTMTLSVGVALAKDITSAETLMETADRNMYIEKHKQRELLTKQHQRDSL
>A0A2E3EVK7|diguanylate cyclase|EC 2.7.7.65|Tistrella sp|TrEMBL
MPTTAGKTAARHDTAADPNPSLTAARRDWHRLQAALAPEMRDWLAGLVAASSDELARDFY
DVLMADPEAAPLLSNEIVQTRLRGSLAGWIRSLFPAGPAPDFESMAIVQTRVGEVHARVR
VPLHLVSRGARLIKAGIAGRIAGSRVGRDELVRLLLHVETVIDIAIELMGAVFVSGITHQ
SRDEEAYRLFFLSQDLSLERESQRASLLEWNQAVLLALAGGSGSTEPLPRIGRSDFGLWF
HHRGGIMFDGTPVLDRVNELMQRLDEGILPETDAARAAGNGFGPALGPIQNAVNEIRFIL
NDAFQALIGAEAGRDALTRTLNRRFLPAILKREITLAMRRDHPFAVIMVDLDHFKTINDS
HGHSAGDAALRQAAETILGTCRSSDLVFRYGGEEFLVVAVEAGEAAARALAERLREAIGK
TEVVLSGDTRIRLGASVGVAVFDGHPDYNHLVEAADSAMYQAKRAGRNRVVVAGGR
>A0A6N3FSW7|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MTEIPNALMLLLILLLSGLYAHASWGLLSALKQDAIPLHYWWPVLGLCLCALFLIMAVFN
LPLPLFFLLLYGLKVCELLHFPDTDRQNWAAVNESFLYTCAACLVLIGLLSFALGMNVQA
LLANPLLRTTCLAALLLCNLITELFLSRHAEALAVFKDIYGSEESRLFIQFTFLGVVFVL
ADAGACLFDLPTTVVSLFLVGSNALLLMMVGFFMNQISIINQENYLEHEHTLLTSTMQQQ
TARTEALKDTAYRDPLTGAYTRLYIFDYLALFLSRGEAFALAYIDLDGLKAINDSFGHLA
GDQYLKAFSSRFSENLNREDVFARIGGDEFMVLFPGITAGAARARLLTIRRRLEAARCEN
WSLSFSFGVSEAPTGTSKPREALIREADLSMYEDKSARRKKEVQA
>A0A8J7VYN1|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MERFISIVQKFRQITITPFFIFGFLALLIFSIFFIVNTWNQSMRETEEEAMQLAMAAESG
FQKSHITNLHIDRSDLEREEYGEIKDSLMDLVLQRNDIRFAYIFVQKEEKIYFLADSEPP
ESSDYSPPGQEYWETDEEFLRLFHQSEPILMGPTTDRWGTWMSVLVPMLDSLTNETYAVF
GVDYPAESWENHAVIHSIQAGIVVFCMFLIYFAFFLVFNQNSSLRHEREKLLALDKKLRE
SETLFRTVFDQAPIGIAIGRNDEHGGTLNTEYGVSINPMFERITGREEAELARVNWTEIT
HPDDVPVDLAYFEKFKSGEIKGYEMDKRYLKPDGSVAWVHMMIAPLNLASNPKYNHICLI
EDITVRKDMEKALFDNERSKAVLLDNLPGMAYRCKTTRDWTMVFISQGCFQLTGYQTEQL
LNNNELSFSELIVPEYRELLWEEWSRVLDLKEQFKSEYEIITAAGEKKWVLEIGQGVYGS
DGMIEALEGIIIDITESKRNLLQIQYMNDHDSMTDLYNRRYFEEVKHLMDRESCLPLSII
VGDINGVRLINDAFGIEEGDRIIQETARIFRSCCRDGDVLARTGGDEFCMLLPNTEHYEV
NETLKKIESCCEEYNLTLKDKAKSINLSIGYGTKQNLDESIQSAEKEAEESMHKRKLLER
SSYHSAIVSSIMATLYERSQETEEHAKRLACISKLIGEKMHLPKKSLDEIELFAMLHDIG
KIGIDDRVLNKPGKLSEEEWVIMKKHPEIGYRIAMATTELQPIAEYVLTHHERWDGKGYP
QGLTQESIPLISRILAVVDAFDAMTENRVYRKAMARDFALEEIRRNTGTQFDPDIVKIFS
SVIESFS
>A0A838MB27|diguanylate cyclase|EC 2.7.7.65|Rhizobiaceae bacterium|TrEMBL
MVFPNISDELMRMALRELEQATYHHEQWSEKLHGTLVCRAVPDKTDLEPDAHCLCRFGQW
YYHTGSIALRNHPGFQEIGAEHERMHRCAAHLLRSSRDGGVVARADYERFVGALKRMNLE
MSNLREELQRALFNLDPLTGAPSRIGMLTALREQQEYVRRSHACVVAMLDLDHFKSINDN
YGHMVGDTVLVEVARWIMAHLRPYDKIYRYGGEEFLICLPETDAATGYDILNRFIAGIAA
LPFAVEGKDGFRVTASVGLADLGAHMPVERSIERADRALYLAKGQGRNRVVSWDASMDEM
PAERERSA
>A0A7L6CGS3|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00994|TrEMBL
MMNDENFYNKERIREEWHQNLSQDDSHRSGIRFSRRVRLARVTGLAAMFFPIAGVLVTHL
IPGGWWLFLVGWAFVWPHLAWQLSCRSPDSHSTEINNLKLDAIIAGIWIGLMGVNVLPAV
ALVMMIGMNMMGSGGFRLFVCGITMTVISTLVTLQLTGRVVAFMPDPLAWWLTLPVMVLY
PMLFAWVSHETAIRLAEHKRHLELMSTRDGMTGVFNRRHWETFLLKEYENCRRSHGDAAI
LLIDIDHFKSINDTWGHDVGDEAIIAITRQLQMTLRAGDVIGRFGGDEFAVIMSGTPAEK
AIAAMSRVHERLEKLSLPSAPQERLHISVGIAPWGPQFGHHREWLKAADVALYKAKNAGR
GRTEVAA
>J2DKT0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLKFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A7W8S3J6|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. CI2|TrEMBL
MDTSKPPRNAATLHPADDVSPQAHALVAEDAPSLASDDALARILADPPAAECPIMVLLVG
DHAVIAEGVREALADEAGIDFRYCASWEDAVRCAEETRATVILQDLVMPGTDGLTLVRQY
RLNAATRDIPIVVLSTNEEPLVKSAAFAAGSSDYLVKLPDRIELIARIRYHSRSYLHLLQ
RDEAYRALRQSQRQLLATNLELQRLTHSDGLTGLSNRRYLDQYLAAEWHRGTRDKTGLGL
LMIDVDHFKAYNDTYGHVAGDEVLKSVAHTIEACLGHSLDLAARFGGEEFAVVVPDTSAG
GLRLLAEKIRIAVEDRAITHAGSAEGVVTISIGAAMVVPSAAEPVTTLIEAAGVGLYRAK
HDGKNQVAVSG
>N9QGW9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 64.7|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A857JF43|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MKALLAVNVLFWLCASYAYADHNEEVERFIIAGQTATYDCPKSDITPALDRYLANQDLAK
EQKDRLSLIKSHSLICVGQYHHAQDILDTLLNDDSINKDSALYAGAVYQAGFILDVQENP
KRCEYYAEAQDLARDRYSDIYLSAQLGLITVCNQDTTDISVKLGKLYALLERFVEIDDVA
AIAHIHNNIGLLYGSIGQNELAAEQYLKSYYMGLEVYTTSNQLATLISAVSANMASGDFV
AAKQNIEIFRQANVEVNTPLTNAWLHYAESRYYFRLEEYENLRNSLLKLHFYLPKVSSTI
IHRNAKLYAIALCIHDDDAPCVNAFLTQQEQMSESEHKRFLAKRDYLWVMSQAYFYTKNI
EKAEKTFRLYAKLSTQQILDQQRSGRVLGVANLHGQITSLENELLEQESQKYRSIVMLTL
GFILLLAGVYFFVVKRYIRRVSTDPLTGLLNERAVIALIRRLPQAHSSRTNALALIEISH
IRRITAKYGHIAAERALQSASVSLRKVTREEDIIGRLGNDQFVVCLRNIDESLALESFER
VQNALDDSHFMTKAGQQENIESQLSVYLSVEGLSDIDDVLADMRGSFPNEEA
>A0A3S4NBW0|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MATKRKVSLVAVLITLAVLSVAIGFANALYAGYQVQKAQAVRNTLEANRAYAQKLSEVIT
LYISAVHRQLDASAAQFSGAPLPEAELASELSRLAARIEGVSAVLLADREGAITARASDA
PHWLGAIPTLTALRVAERRIGEWVRPCCQPEGSPATLTLVNPLPNGALAAVVVLERGSQI
DKLIGEHPYADGTAVYLVNRDGQALYRHGASGTSAALPDLISDGSPAMATPGSAQLQDAA
GHTMLTGYAPLGKGNWAVVVQRPLDHALSPLNALLREALLFAIPAVLLTLLLVSALAYAI
ARPLARLTHALANADAAGPQDQQASGLRTWYVEADELREALASRLARHRHEVGRLNVESM
TDPMTGLMNRRAMRQRLDELVATHTAFAVIALDVDHFKHINDTHGHPVGDKVLIALADTL
SRSVRQQDQPFRVGGEEFVVIVPAASDDAALATAERIRAGVSQTAMPPGVGQVTVSVGVA
LWPQDAALPQAVVKGADLALYASKQNGRNRVTRWNKQVLSTMPEGKVAT
>A0A379INH0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MIAHTQTLFGAVALVAVIMGSCLILVGQLRHRDGMLTTGLGMLSHALAYIGFTLFGLASM
WLTYVLANTLLSTALAFYTVSLPLIHGRRPPWRLAFAFPLLLGVLLSLLIDTQEPRQLVA
CLLLFSQCLVILYLSRLHAVPGGRAHRILMIGAGISLFGLGIRVVVILSGAPAEMHYDVS
NLKQTVSVALGAATIIMFSFGLVLLSRERIESELRQTALRDTLTGLPNRLAILEQLTDEL
ERARRQHTPLSIAMLDLDHFKLINDSHGHLVGDAVLRHCANHLQQRLRRNDSIGRYGGEE
FLLVLPGTDANGALELVDQLRQSLTQHPAQIDSKTIALSFSAGVYGSSNSIAEDITGMLL
KADTALYRAKHAGRNTQVLATAD
>A0A3S4T0L8|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MPPHWLLKFDLHRLILALAVLGVLATFGNSFYAVHQAQRQLLIASTLEANRVYAAKLAAS
ADAMLQSAQGQLAYSASLLAPLLQARDLGGLDEEVSRLRLQTNTFNSVVIVNRDATIVAV
SPETLQLKGAKLSSPISRQALNLQQPLISDPFVSLSGNYLISLSYPVFAADQRYLGYVAG
TIYLQSASILSSMLGQHYYQDGSYLYVVDREKTLIYHPDPQRIGQKIEDNQVVDEVLNGQ
QGALSVINSGGTDMLAGFAPVASASWGIVAQRPRSATLAGLDEQLSGVLMQMVPLTLFIL
FVIWLSATFISRPLRQLANRARLMDQQEAISNIAGIRAWYFEAAQLKQAILKGLGLLNTK
IDKLHNDSHTDPMTGLLNRRAMQQMLDEYQAERRALSVIALDIDHFKAINDNFGHDVGDE
VIIALAGLMQQEIRPDAALFRSGGEEFLLLLPGVSLSQAQAIAERLRLKVAAHEMARVGR
VTLSLGVAHWPEHASATLGEVLKCADKALYEAKHQGRNCVVVGMC
>G8ATR8|diguanylate cyclase|EC 2.7.7.65|Azospirillum baldaniorum|TrEMBL
MSSTIERYLLAEKAGSEGVWDWDLRNDTMFLSPRFKEFLGLPPGEINRPEDWLDHVHPDD
IDWLYASFEGQMVGVSLPFQIEHRVRRAGAGLSPDNGDSGWRWLVCRGMAVPDESGDPVR
LVGSVADITDRKHAEAQLRKSEERYALAAAASNDGLWDWDLDAGTAYYSPRWLSLLGLEE
GSIGNSPDEWMERVHSDDRRSLREALDALGGENTVFQIEYRVHHADGGIRWMACRGIAVL
DAQGRPVRLVGSQADVTDRKTAEQRLLQSEERYALAAAGANDGLWDWRLDTDQVYYSPRW
AAMLGFAVDSLSNRIGEWFDRVHPDDLAGLRTAFDLHLTGEREHLQHVFRIQAADGDELW
MLVRGLAVRDGSGRAVRIAGSMTDITAQKRAEQQLLFDAFHDGMTGLPNRTLLLDRIGQA
LDRNRRAGGKAFAVIFVDLDRFKSINDALGSSVGDRLLKTIAERLDETRRMGDTLARLSA
DEFAVLLDGIDDVGDALSAAERMGEAVARPLALDGHDLVLSASIGIALSVSGYDRAEEML
RDASLAMYRAKSGGRARIDVFDSNLRRQAMAQMRTETDLRMALEQDQLVLYYQPIVALSS
GQIAGFEALMRWKHPERGLVPPGEFIPLAEESGLIVPMGRWALRVAARQLGQWQARFPRS
TPLFMSVNVSSRQFSDDDLIGLVSEVLQESRVPPSSLKLEITESLLMKDPAKCRVLMQGI
RDMDVRLSIDDFGTGYSSLSYLHKFPADTLKIDRSFVQAISSGEGNAAIVQVIATLAAIL
GMDAVAEGVETEMESEFLRDIMCKYAQGYLYARPAPADAIEALLLREAEEPLALPSLA
>A0A5P9D8Q2|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. THAF82|TrEMBL
MEVSQPPNESDRLKALHALQILHSERLPEFDAVVEAVATVFECPISLISIVDKDQQWFKA
KCGLDADSTSRDVSFCQHAILSDDLFVIPDARKDARFRDNPLVTGDPFIRFYAGCPISID
GKNRLGTLCVIDREPRSPSDAQLAQLKRFGKIVEGLIKSHRAELQVQDALDKAEAESRLA
TQESELLEEIATVSGVGGWELDLDTNQLIWTDKTRELHEVDADFVPSVDTALSFYAPDGR
EIISDAVARGIEEGIGWDVELPFITAKGNELWVRAAGRPIFENGRVCRLVGAFQDITERL
MSEKAVRSSEAVQRTTLETLREGILVLSATGRIQSLNPAAAKMLGLTAKTAAGQNVQDLI
ANIRFQTEDGKADDDVLTRAAKLPHEVNNHIVKMNRSGVSSSVWLRIDANATASAGGAGL
DLTVVSLADITETKLQAETLQVVFDNIHGGLVYYDENRRLAANNDYFQQLLKLPEEFIDT
KASLQEVAGFLARRGDFGPGDPDQLIKERFSVFDNPEPHVYERAGPDDTTLEIRGNPTPS
GGLVTSIFDITERKRTEQSLKISEAVNRATLAAVSEGIFLFDSNGIIQVCNPAAAAMVGY
RADELVGMAVQDLDVNIQCSLNGQHCDPFVLAVDDPDFVTDLIASITPHDCETSIWLRVN
ARSIDPSEEFGLKGVVVSMADITETKAQADQLQIIFDNVPGGFAYFDAGHQLAFYNDELI
ETLQVPRDLLEQKLHLLDYYKFNAQRGDYGPGDPEVLALERFKAYPPDQPHAFERSTSDG
RYLDIRSTPLPSGGFIYNFFDISERRRMEEKIAESERQAHLRGDELEAILANMRQGVSVF
DKTGRLSLWNQQYLEIFGKPEGEVRKGASLVELIEAEKARGEFDGDVKAHVMDLMIQLSA
GDVVRSKFKHPSGRVVSAVHAPMPGGGWIGTHEDITSQELAAEKIEYAAHHDMLTGLANR
TLFNKTLDEALDRAILSEHTGDLLLLDLDRFKPVNDTYGHDVGDEILKQVAERMKACVRS
TDLIARLGGDEFAIILNCTGEHTAEIAARIVSNIEQPFTALGHTVSIGVSVGISPIFGET
EDVSPIIKQADIALYEVKKNGRNGFRFFDGNLTEATVN
>E2XHC9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MKLRHPGGNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKHESFLICSCTDI
TEERRAQERLRILANTDSITGLPNRNAMQELIDHAINHADNNKVGVVYLDLDNFKKVNDA
YGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASQILTRLRL
PFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRV
FEYLWLDTNLRKALENDQLVIHYQPKIT
>Q3Z191|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MTWLFCDRIATKIDKNNGISMITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDL
TFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALNCRLVLRKLTEAEP
VIIFEGIEASATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAA
LNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTY
AGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLA
IAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLL
PRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAK
NDGRNRVLAA
>A0A7U7J1J2|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MNTETILIVDDDLASLRLLMEILTAEGYQVRPADSGELALAAVEAQPPTLILLDLLMPGM
DGFEVLRRIKAREKSRAIPVIFLSAATETEHRVAGFKLGAVDFVSKPFQRDELLARVQTH
LELFRLRTQLEQRAAELQSINERLLIAELAERKRSENALHESEQLLKLIIDTLPVGVWLM
DAQGTVVSANPAGQQIWAGIRSVDIDHLEEYKAWRLDSNKQIEAREWAGARAVEKGETSL
GEEIEIECFDGTHKIILNSALPIRGSDGRIKGAIVVNQDITARKAAEDEIKHLAFHDLLT
QLPNRRLLLDRLHQAMAASARNGREGALLFIDLDHFKILNDTLGHHYGDLLLQQVAARLI
TCVREGDTVARLGGDEFVVMLEDLSGNPQEAAAQARIVGEKILATLNQPYWLSSYEHHST
PSIGVALFSDHRETVEQLFKRADLAMYEAKMAGRNALRFYVAVP
>A0A7Z9DUR3|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MISITKISQSTMQSNLLIVTSDTPSIDAINLMNERGDDCVLVIDQQQLIGIVTERDIVRT
IAAGIRFDQVPITTLMTPNVITCQESEAKDSLQVIQKFHRYRIRHLPIINSQGEVVGMIT
PKQIREYLTPYDLLKLRRVEDVMQIRVIHAPPTTSLKQLANLMTTYQVSCIVITQLQNQE
LIQPIGMITERDMVRLQQLNLNFESTLAEKVMSSPVIEIQAKQSLWSAHQQMQQDQIRRL
VVTTTEGNLIGIVTQSHILRVLDPGELLETIDILQHTLDLQTGQLKQEMQLVQSLVQQEA
RYHRLLDSFLEIVCCYTVKGTLTFINQAGCQYLGQSASELLGQNIFSRLQEHEQNLWRDQ
MIHLLETHEETLTYQYVIGEESNQQKWLEWTVQVIPDTTGQNTEFQAIGRDITKRKQVEL
QRQQDITELMTWKHRYELAGQASGQIFCEWNSAKNQMTWGGNTPEILGYSQTELPLHLEG
FYQLVHPNDREQLKQQVQQLITTQSPCLMEYRLRRRDGVYIWVEDRSQFITHTQENDLML
VGFIQDITSRKQVEAALRQSEAELRAVFGAMSDLVLTLDDQGRYLNIITNNPQILYQPAE
QLIGKTPHEIFPKSLADQILETVQKAIQSQTTIHLEYCLEIAEKNTWFSANISPLSPSSA
VAVIRDISDRKEVQEALQETNLALAEAQKMAHLGSWSYDLITQQIHWSEESFSIHGLSPD
QQVPSYEELLEVFTHPDDRELIRYRMEQAINNGKQFQQEIRIFCPDGSLHYILIKCQRVI
NEQGQIIRLFGTLLDITERKQIEETLRQLLKRERVVTEITQRIRQSLNLEEILNTTVLEI
RKLLQTDRVLIYRCEPNETATVIVQSLGVEWISLWGQQIPSIYLTQEQCMIPFSQGCLHN
ISDIYIANLKTDQLHWLEQCQVRACLGVPIIEGEVLWGFLMAHHCACPREWAYWELDLLE
QFAAQVSIAIHQSQLYEKTQQQAQREKGLRRVIQAMSQSLDLETIFSTATFEIGQLLNVD
RVSIAQYLADQNHWIMVASTTQSLDIPDAIGIMISDENNLISAQLKQQKVIRISNFQNDG
TQPLNQNFAEMNSGALLIVPLWVGSCIWGSLSLYRHHQTWIWQDPEVELACTLVEQLQVA
IQQSQLYQQLQIANKRLEGLVMMDGLTQVANRRRFDEYLTQEWKRATREQHPLALIFCDV
DYFKNYNDQYGHLAGDECLIKVAQALDGSVRRPGDLVARYGGEEFAIILPQTSIPGAVQV
AEIITETLKFLQIPHETSLISSHLTVSMGIASLIPALNSSPQVLIEAADQALYQAKAQGR
NSYIVYISPESE
>A0A3S4GPY5|diguanylate cyclase|EC 2.7.7.65|Paracoccus haematequi|TrEMBL
MTHTLTLGQDALDRLMPMHLCIAQCGLIHFAGPTMRKLMPPCAQGVEDIFVEAQGAASGH
VIGAIRGAAPGDRLALRLRHRRQLMLRGHVVTPGFGGLLLNFGFGVSLSDAVAAFGLTES
DFAPTELALELMFLQEANRAVQQELARFNRHLMLARQDAEREAHTDALTGLLNRRGLQAA
LRNALDPRGGMGGFALVHLDLDNFKQVNDRLGHAAGDRLLGDVAHVLGRVVRSRDHVARI
GGDEFVLILGGSWSCQALTAIGTRIIRGIEEASPEGCGISASLGIVLSAGYAADAIDRML
EDADVALYQSKRMGKGRVSVAPLPLEGGPRPLTAPR
>A0A5P9C3T3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MSLRKRLFSLFAPLLVVTLLIVQLLSDHLLLRRFDQQDEQNLQDAASKAQQILFDHIEQA
AQLLRSYSWWDQSYAVAQARSPVERYLEEDLDDTELDNYDFDFMVMFDAQGRLLLERWGT
FDTRELLVLGPGGEPSREDMRNDVYARSAATGILDAKGDPRFTTAQFLLVHGVPTLLLSS
AVTDSDGTAPAAGAFIAGRFFTTSRMTSLAHQFVGQVAFIPAVTDTTGWQPRHEAPLGAE
VSPRELLSDKRQSILLQLDNPWQAPELALRITTERSNYNGAHDALHFFLAISFVIVLGAA
LVVYMGLEFWLLRRLEVLNREIDGIGEQTRLPKLADLGRDELGQLGSALNSMLERLEQSE
QRDRAILESIQDGYFEVDEHGHVQRINGAMVKILGYSSEELLGRPFTQLLLRGHTATALQ
YFQNARDDSSLRTLCTPMRRHDGTLGDFEARLSVIQDTDGTFRGYRGILRDVSAQASQRR
KLHTLAYHDTLTGLGNRKAFLEHLPQQIAEAQSQGKQLALFFIDLDHFKQVNDRFGHDAG
DELLRAIALRLQHALRQPDQLYRLGGDEFTLLVSNASAETARIVGERLIAALRKPFDIAG
TCIDFVTLSIGIALCPLDGQDAVTLTKAADSAMYLAKRQRSHIVIGPATQGTPQE
>A0A5P9C8J9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MDQILSLLSETVPQARSLEQLARPLLALLGQLTGMESTYLTTINLEQGFQRVEIARNTGP
MVIPEGLVVPWADTLCKRALEENRPYSDNVSECWGDSDAAQALGIKTYLSAPIRSQAGHV
LGTVCAASSQQVACSPKVEPVLRLLSTLLGYFLERELLVEQLQAANAELATLALTDPLTG
LANRRAILRDLEHLYALAQRDNRYVLIGVIDLDGFKLINDVYGHQAGDHFLQGVANQLKR
SLRNSDSVGRVGGDEFIVIAQGASPESAALDQELSTAASLMQERLSRATIGRYPLGDGVE
ALDYQGASVGVAAVMPAETTAEEAIILADGEMYRVKQQRKRQRS
>A0A4P8C1L0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:NM|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A143QG92|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MLGLLGTDGGDAVPTDHDLPSPSSEIGPRSGSIRLERRVARGIAVLVPSFGVIGAIIMLS
DDGPVGTTAVLICTIVLLSTLPVGAWWWLRSVDASHMPGWFVIYADVGVSGLLLTFADRD
LALYGAALFSVIGTYIAYFSRRNVLKFHTAFVNAVILLLAVLAVLERPDDPASIVARALV
TVLVVNSVLAFRAVIQRQLDLANTDSLTGLLNRRGLELRLERMLGRLADTESVALMVVDL
DQFKRVNDTFGHAMGDRVLRRTARRLSAVTGRRPCVARTGGEEFTIAVPVDADSAKHLAD
DIREAVHDPGDDVPVTVSIGVAILDAGQWRSADSSYESAELMHNGLLDADAAMYESKHAG
GNKATVYTGT
>A0A377IT67|diguanylate cyclase|EC 2.7.7.65|Fluoribacter dumoffii|TrEMBL
MTGALSRVTMLSTLREQQEIIKRQGQSCCLVMVDLDYFKEINDRHGHQMGDRVLATAVRL
FIENLRAYDKVFRYGGEEFLLCLPFTDLDMGFAMSERLRKVLEAITIDDGKEHLIQVTAS
FGLALLEPNKPIEESIEHADKALYLAKSEGRNRVRVWK
>A0A7Z9E518|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MKYWQKWLLNPSHQIPLIYGIIGGLWIAFSDHLLALLANYPHSITLLQTVKGWFFILITS
LLLYYLIRRETQRLQLSEKRYRDLFLSHPQPIWVYDLKTLKFLAVNDAAIAHYGYSETEF
LRMTISDLCPPEVSESLQVLITSDAGGIEPENLFKHRQKDGTLIDVEIRSHPLQWKNRLA
KVILAQDITIRLQAERQLERYAFQDFLTGLANRSQLVYCLNHCLESSTTDQNFALIYINL
YPLKTLRYSWGHGLAEQLLIEVSHRLKRCVTVQDIVARVDSEDFAILIPDFININNLNSQ
INQIKHQFLTPFNLNGTNLSSAISMGVVCREFNWENPEQYLQAADIALHYAKKQGKNATL
FYHPQMLETITQRGALETDLQQAITHNHLRLHYQPIIHLNTGNLIGFEALVRWQHPTKGL
IPPAQFIPIAEETELIIPLGRWVLEQACQDLFKLQKQYPHLSMSVNLSEVQLHYPPLLEE
IDSIILSNGLAFGSLKLEVTETSLMESSANCITILTQLKNRGIKILIDDFGTGYSSLSYL
QNLPIDTLKIDRSFVKNLESQGKDLEITKTIVNLAKCLNLDIIAEGIETSVQKEILQSLG
CEAGQGYLFSPPLNWAGITTFLSS
>A0A7U7GGG0|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MLWIAAWYAADRLNHWGGVSLWYLPAGLRFCCLLVFGWRGLLLEWVAELIALLFTTPGMD
SISVFLSAPPYWLLYHWMVMPLSYAAVILPLRRWMRNPWDFTNPGHRALFLVAALAVSAL
AALAGTFGAVYSGLIPLTQGPEALLSWIIGDFTGIIALVPLLLVRVWPGLHHYLQQGCWR
RLPLSTAVSSSSDLSTMLIVALALLLVFGIPWRLDLNPHFPLTALLLLLPLAWITLHYSL
RGAVLAVVMLDSGLVVLIVLFGQRDAALPYQLVMIAIALVGLWLGGVVEARNRLMVRYRD
FASASNDLLWETDVEGRLLEASGRLARHVVLTPGQSWRLLLNDGLQPHLAALEHALSQQQ
PFHHLEIALQGAGETPRWIQLNGLPLLDELGELIGYRGTAVDVSRSRRAEALLRNYNEEL
LHEVSERTRALRQTNGELAAKERHLQVLLAAAPVGVLELDDAQCCRYLNANGCALTGCTP
EQAQGRHILDFVHPDDRDYVDFIWQINRQSDEVQWLEFRLNRTSLWCAAHWINLAHSDES
MDGAIMVLTNATARRQQDERLWTLAHHDTLTDLPNRSLFWDRLGQALRRAKRRESGTAVL
WIDLDGFKAVNDSLGHAAGDALLQQVARRLKIRMRDSDTVARMGGDEFAVILPDITESEG
AVRVATELTASLAEPFELPQGPAHISGSIGVALYPQHAETAETLTQYADMAMYTAKHAGK
NQVQVWYGR
>A0A6N3I167|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MNKKVRSDSIAFKLALTFVVSVVIQSLLMTALLSLGGVIGQSRENAYQIFSEKVKNRAVT
IEGEMKNVWTNFELYTDELSRYFAEAERDENGELLEKEELLKAAAPTVLNALYYTKTTGA
FLILDRGDDGNGSYPALYFRNANPNRVDERNSNTYLLAGPWDVAQETQVVTDAAWKYQLE
LTDANRAFYEKPFSSIGLAGDEKLLGYWCPPFRLYDGGEEVVTYSIPLVDQRGRAVGVFG
VEISLNYLYKYLPPSDLMAVDSYGYVVGIQTGENGEIRPLVTHGALQKRILQGASPMELK
AKDAENGIFQLENHNGNEVIYACLKEMGMYYNNTPFSGEEWYLIGLMDEDALLRYPHRIQ
EILVYSFLISLCAGAGIAVLISRWFTRYSRLLELSEVPVGVYEMGSKGNKVYMTNQVPRL
LGLSKEQERAFCRSQDEFQAFLKKICEKPTEDENVFCLERPEGKRWIRLTFREDDGKKSG
VVEDVTEETLKTQSLRAENDLDGLTRVLNRKAFERRQQKWDGMLRLGKPLAVLMFDLNCL
KRVNDQFGHETGDKYIRFSARAISGALKDAWIYRIGGDEFAAVLEGVPENSIEECCRLSA
GQVEAYGKENGFEAGIAWGYAISASDSAETFGDLLSRADHNMYEMKKQMKNIDKS
>A0A6N3GWU2|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MMELKKAQKELDMLSETVLGGTARLSVDDEFRIITATDGYYRMTGYTEAESQSPPFCGKG
MNLVVPQDRPIVTEALQKLLVTNEPATVTYRIQKKDESIAWNTAYCARVDKTGAERTVNV
FFIDITDKHQAETKLESLINTIPDSLIRLLIGKKNMVRYVNKEFYRQTGWQPEELPPGSP
LSQFYQIIYPDDRQMVKTQFLDYVKSDLDSCIMDYRIRTRQGDVKWMHARAFRFRSDMET
GQIIQFIISDITEEKLQREATALNEERYRIISEQTRDTVFDWDILKDRIQFSPVYEKMFG
FPPPPDVSIKNLTEYDIVHQDDKKNVEDMISAILGGAPYAEAEYRAKRADGTYLWCRNRV
TTIFDSEKRPVHAIGLLSDIDDYKQETALLQEKATRDSLTSLLNRMALQRQVERRLKKYP
GRLNAFLLLDIDHFKEINDTQGHSMGDTVLKSISALLSQHFRSTDVIGRMGGDEFAVFLT
DLPSPSATLRKAGELKHKTAQLFESGPLSGTVTVSIGISLYPYGGKDFQTLYQKADEALY
QVKRKGGNGCFMNSPHH
>A0A174P2N8|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKYGEALLWIVIIFLLYMNELRIDQLPGIGEGETGTKVEYMIRAFVKAGILFSGWYIHLP
LFIVYLLIFCGYGMTFWSIGKRSRLNLFFWMNFFSVCFIAVNLISMAAVSLVTGSMLRDV
YLSNTYCVITLCITLIMIHLMNKLWKKKIFADWITLLTSDEKRFNQLIFFEWYALGYLIF
DSTSCVFVLPYSLLSVFLIGSCILLMIQFILFLAHTHRIIEKAHYEAEYYRLEEERAEHV
KRQMILQKLAYIDGLTGAFTRRYAMEMLESMQKDGLEVTVAYIDVNGLKKVNDTLGHQEG
DRYLKLIADSLNESLNKSDILSRIGGDEFMIVSNSAEKEGLESMLKKVNELLGTAGREGY
RPSFSYGVVSAPHKEPFDLEELLRESDRRMYVNKMQFKRGNV
>A0A379I3V3|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MDIAALNSTEFLRKNVLKWVSLCFGCLALVFSGFNLAVNNLSVLGYFEAVFALYCFCIYF
RLGKHPVQVWQSVVMCAFISFIVVFGAYMATLNNAVFVWALVLPTMYYLLLGKNYGFIFS
MVLLSLQSIVLMNKSSLAPFTSLNLYLNILFAYIVIWAISHTFESNRAQFSKRLKNLAML
DPLTGSGNRLAMNHYFSVELHERTQLYLFLVDLDFFKQINDKYGHDVGDKVLIEVATLLK
VTFAKGYVFRIGGEEFALISSFNSEHAALAVAEKVRAALENKYINVDNYKINLTASIGVA
RYKPQQSLNELLKAADKQLYKAKDLGRNSVYYPAVKSDKTALI
>A0A165LXA9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MPTDHDLPSPSSEIGPRSGSIRLERRVARGIAVLVPSFGVIGAIIMLSDDGPVGTTAVLI
CTIVLLSTLPVGAWWWLRSVDASHMPGWFVIYADVGVSGLLLTFADRDLALYGAALFSVI
GTYIAYFSRRNVLKFHTAFVNAVILLLAVLAVLERPDDPASIVARALVTVLVVNSVLAFR
AVIQRQLDLANTDSLTGLLNRRGLELRLERMLGRLADTESVALMVVDLDQFKRVNDTFGH
AMGDRVLRRTARRLSAVTGRRPCVARTGGEEFTIAVPVDADSAKHLADDIREAVHDPGDD
VPVTVSIGVAILDAGRWRSADSSYESAELMHNGLLDADAAMYESKHAGGNKATVYTGT
>A0A0L0GYB4|diguanylate cyclase|EC 2.7.7.65|Trabulsiella odontotermitis|TrEMBL
MQSYVARVKDEWLGLIRETEPHIHEMARGLGEDHARDLSEIFYTNILTDPQAVDFLTNEQ
VETHLKKSLVVWVKRVLSCTENDVDELIALQQHVGEIHARIGIPIQLVDMGARILKRNII
PLIIERNGSENDKIKLLSFSLSSIDLALEIMARTFTFGESSSMKDDENYRIFSLLENAEE
EKERQIGSLLSWEMDVIYNVMLETDLDSIQLLSRADFGLWFNHKGRHYFSGIAEVGYIAK
LMQETDQILLKTREGSRTFRQKNLRNDFMLQIKNNTTQIAALLRGLFDDVSKHEVGMDVL
TKLLNRRFLAAIFKREIAHANRSGTQLSVLLIDVDKFKEINDGHGHATGDDILRKISQVF
YDNVRSSDYVFRYGGDEFLIVLTEATPTETMHIAERIRAKAMKQVVNTPDGKQLTTTLSI
GAAMFQGHPDYERLVQAADEALYVAKRNGRNRAEMYNPNNKA
>M7NIP6|diguanylate cyclase|EC 2.7.7.65|Bhargavaea cecembensis DSE10|TrEMBL
MAYQALQGPCGQKLIMLEKELQRLRELVYMDALTGLLNYRAFKEEMQKRLDTGKAFGLLY
LDLDRFKQVNDQFGHLAGDRLLREVASVLEIAAGLDAQVYRLGGDEFALIADTGQDIETV
HERILLGFEQEDKLKIGDLRIGVSIGSAKFPEDGRTYEELLGLADCCMYADKHRRKADHF
V
>A0A1V2RM40|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. MP131-18|TrEMBL
METETEPYVRLASLRELHQVVAQLNTARSMADTLQTIADGAVAALGFELAAVNLVRTDGD
LLVAAVAGSDKAEAAIAGRTGSRESWERRLSMGERWGELRFIPYTEGWVLDHDDVPQWHT
TGPAPRYPEEWHPMDRLFAPMYASDGELLAVLEVDRPRNGRRPGTWGCEALQLYASQAAI
AISNARLRGNMQRALIRLEREQQALRASEESFRQAFEYAPSGMAIAEVGGENHGRLIKVN
DALCRLLGRSGPVLRRYSFSDLVHPEDTGVLLRTAAEGGRAELRLARRDGSYVWVSLRNS
VVADAADGPQVQLTHVEDIEERKRHELALAHRASHDSLTGLPNSAELRARLGSRICATAP
DRWDVTPTTGRATDAFAGIGTPPPRPYDHHEHVYTPELPGGDGKGLAVLFCDLDGFKSIN
DRFGHVCGDAVLVEVARRLEQGVRDRDTVARLGGDEFVVLAEGLGQAEASDLAVRLRNAI
IPPIRVEGRGVRVGASFGIGWAACGMTTEEVLESADQRMYVEKRSRSQGRRRAG
>A0A5E4RAZ0|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MRIRHWLYAACVAVGVLVACWVAADRTATSLVGDKLAQSVEAEQTVADRVADGMIHAINT
DLAMVRAIPSTLAEVDLLRDVLRPASGTANAPDVVARANDFLQSAQGYFGVDRVWLVDTR
GVCVAASNYRDTPSPVGQSVAGLPYFTNAILGARFESYAAGWEHQAPGLYFSAPVYRDGI
LIGVVMTKIGLARLRHWVANGESFITDGNGVVIMANDPRFENRFMLDGKLGGLSDIERQA
LYQRNDFSRMPIFPFKRAPGRANAWVPQELLDQMSEFDEFHKPFVITQRASSSNDLTVYA
VENVDAWEGLTRQHAKDFALCFLLYLGGVIILIMAGRIYWRERRMHRQTLQSNEELRAAN
NQLAFEASYDELTGSLTRRYFFHRFDQLLENAQRKNEPMSLIVADLDHFKSINDTYGHAI
GDQVLCRFVLVCSSTLRGDDLIGRIGGEEFAILLPGASERDALRVADRIRERCKRESLEG
SEPPLRFSASFGITEWQDEDSAMNMVERADMALYRAKRAGRDRCWVF
>A0A2H5ZSC4|diguanylate cyclase|EC 2.7.7.65|bacterium HR31|TrEMBL
MLDGNSVATLERSVRDRVVQNWISAVEGRGGRARVALQARGRALLEGTEAVLRGDPDGLV
DRLRRDPQWGLSAIQSLAEELRQLLLFRAVAMEGIPGLTDAQKEALHSAFDRAAVELAKW
FEALARAAGDAQLEAERIRDPSTGLFNRRYLEIALPVEVQRALRYGHPLCVLAVRLDNWE
ELLGRWGQGVVEEVVRATAEAVQRVTRAVDTKFFVEPDQFYVLMPEANPDYAFVIAERVR
ESVQASVPHGATVSVGAACCPLHAEDARSLLERAEEALATAKRLGGNTSLVYQPA
>A0A238JRD0|diguanylate cyclase|EC 2.7.7.65|Actibacterium lipolyticum|TrEMBL
MARLMPMHVMIDPAGDIRAIGPTLQKMRPSEQMVGRKFLDVFAPRRPRNVSTLEQLLMAE
GERLQLSFRQPPQTDLKGLIIHLGDDIGALVNLSFGISVVDAVADYGLTVGDFAITDLTV
EMLYLVEAKTAVMDESHKLNQRLQGAKNEAEEQAFTDTLTGLKNRRAMDHQLIQLIDDGR
PFALMHLDLDYFKKVNDTYGHAAGDHVLQHVARVLVDETRSTDTIVRAGGDEFVLIFEGL
IDTKRLNAIAYRIIAKLEQPITFNSHPCEISASIGTTISSSYDAPEIEKMLYDADAALYA
SKRAGRARATIAGDWHLSDERERPETPR
>A0A732CV60|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 18:z10:z6|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>I6CXK9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVL
ARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGIALSPEHGSDS
TAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRIFEYLWLDTNLRKALENDQLVIHYQPKI
TWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVVRQVTKWRDKG
INLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQF
SQLGAQVHLDDFGTGSSSLSQLARFPIDAIKLDQVFV
>A0A1M7YPV7|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MHHHVLLRPWTAIIFLLILGCAYTGLIEFLFLTHQQAMRHDIQQRAEDELALVRYKLEAS
ILADAYAAKSLSMLISVHSQAVSQFWQSVSQQTIEQGKYIRSVSLAPDDVIRYVYPVEEN
KKAIGTDFRSIPEQWEAVQKARQMEEVVVSGPVKLVQGGTAVIVRSPVFLDPLKNQHYWG
SVSIVVDIDKLFSFLNFTDLASHFDIAVMGKDFTEKEGNVFWGKPQVFQHVFVQEMFYFP
SGTWQIAIAEKQGNVDSRYSWYQYYLVRIIGYSLFVVLTMSFLTVYRLYKKSNQLSMCDE
LTQLPNRRFFMDRLSKVFENKKQRGAASGPGFSLLCIDIDKFKLINDQYGHFVGDQVLIE
CARRIRNAVRDSDCVARIGGDEFLVLLIDGVHSHYIRGVIDRIRHTFELIPIQCEGHSIL
LEVSIGYTTYMDEMENVSDMIKFADSNMYAEKYQR
>A0A1M7YXF8|diguanylate cyclase|EC 2.7.7.65|Vibrio quintilis|TrEMBL
MSNDFEIKKKIFCHEVKEFFISGRKASYLDNIPALFNEGIISKFNIVTDVLKDLIASHIA
EKEDFQVLIERYLELLSVLVRMEHHVCYTDHLTGMFNFNYLKTLENELNHKEFSLYFFDI
DNMKLANDKFGHEYGNEMIVNFAKALKQSFRLTDLIFRYGGDEFIVIILRDDIEIEDMIS
RVQNQTCIEKYQMSFSVGHHLNTNASLFDTIHQADSMMYERKKNK
>A0A8F8DDY4|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TC-EC600-tetX4|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A4P6M453|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MRKLQNRKEPAEELKEKSKERLRVFALYLILVMVIVLLFWMNGVTAANNIGFDNENVYIL
NEGWTMVRGQEAQPVTLPVDGSSAAGEAVSYTKILEKQDSYCNMIMFHSSHQRIKIYLDE
ELLYTFGYGQSTPVRASVGSAWQYTRLPEDWDGKELRIETRGVYDSYSGNQETVYLGTKT
SLVFMVAKQKMVSLLVNLFLFIMGVLLIISSFFFKAAHTEGRIRYLGIFAIVTSTWILLK
SGVGQIFTGNILMSMNILYLLFGLMPILTISFLLTFDSFSKNTFMRGLYWFSVGSYFAMQ
FLQLADVMDYTQMVSLNHINFLLIVIGMAGICIRKKIKGEKIQDISVFVACFTFAGFGAV
DIYRFYFEKTMQSNVGFTQAGLICFVCSLGYSVVKQSSEEQTQMIENKTLKKIAYMDILT
KLPNRTAFENRMEYYRTECLGQGPMVMIVDLNGLKEINDTYGHKAGDLAIIRIAQLLDRH
FGQPLRTYRIGGDEFCVLAEGETEETFGQRIRHFLGEVEEADKEYAFSFSAAYGYVKSGE
EGIDKAFIYADKKMYACKMQMKQELAKEKSW
>A0A7U9XQK7|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MGYAEIPYDRRIKENIRNYTLINLYDMDIIKKYLNNLAEILELNLLLTDRHGEKEIVVGD
SFVGFHPDVVNEPGRKLRVQNYTIGHLYVKQLSESRDKALINEMVDGTMKLLDRLGEEAY
LHRESSIYLEELEKQLEDKKHKITQNEREDILTGVFNKLFFENRMKAIDRSEVVPVAVIN
VNINDWKFANDHFGDDESDRLIKIVADILKEEAKQYFILGRVDGDAFGVLIPMAEDGEAE
NYAARIQERCNTYEDPVLAPSVAAGIVYKTNIEETLEERLSDAEYEMFNNKFEVKNAPGY
KERLTRGIHN
>A0A8F8C3Q1|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. Y33R10-2|TrEMBL
MTKPTSSIRGSTSLKLSLILPFVALIALLTSALGMLWYWTGSNTVSALSEQVMEEKVERI
ALIVDRHLYSSSAVLEAAFPSGQPVDDDISSHTQSLISRLWVATSLHTQPNDYVYYGNVA
GQSIALKRLQPQLGQLRLKTQAGDHRSYYKLTGINAEPVIEYTENTLFDPRQRPWFKLAA
QTEGSIWTPVYIDFSAQDLVLTRAQRILSPQGQLQGVVATDISLKALNSFIAKLHLSEHG
RAFIIEADGSLIAATGMANILLQPDGKMERMSAANSQDPLIQAVYEKIQGVFHASIPDDS
PHTGVLEDAVHNKIRIAYRRLSNGAGQDWLAVIAVPHKDMLAGVYRHMMLVGGLGLLALI
VAVFIGTRIFGAVANDMRSLTRAVRRVGQGEIDTPIEVQRRDEIGELAQNFHRMRHSLFT
DPLTGASNRSALQHILSTLTRPLPGQATAAPFTLLFVDLNRFKPLNDRWGHDNGDLALAE
VTLRMRNLLRPDDVVARLGGDEFIIILRGVFDEEQIQAVRLKIDLALQQPLITLQGLPEG
ELVTVGASVGQAVYPRDAQDSQTLLKMADQDMYRNKGPSVR
>A0A161Q3F8|diguanylate cyclase|EC 2.7.7.65|Tistrella mobilis|TrEMBL
MPTTAGKTAARHDIAADPNPSLMAARRDWHRLQAGLAPEMRDWLAGLVNASSDELARDFY
DVLMADAEAAPLLSNEIVQTRLRGSLAGWIRSLFPAGPAPDFDSMATVQTRVGEVHARVR
VPLHLVSRGARLIKAGIAGRIAGSRVSRDDLVRLLLHVETVIDIAIELMGTVFVSGLAHQ
SRDEEAYRLFFLSQDLSLERESQRASLLEWNQAVLLALAGGSGSTEPLPRIGRSDFGLWF
HHRGGIMFDGTPVLDRVNELMQQLDEGILPETDAARAAGNGFGPTLGPIQNAVNEIRFIL
NDAFQALIGAEAGRDALTRTLNRRFLPAILKREITLAMRRDHPFAVIMVDLDHFKAINDS
HGHSAGDAALRQAAETILGTCRSSDLVFRYGGEEFLVVAVEAGEAAARALAERLREAIGK
TEIVLSGDTRIRLGASVGVAVFDGHPDYNHLVEAADSAMYQAKRAGRNRVVVAGGR
>A0A7U9T0H1|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MNVEEEYLSLQEQCRKKILKSVYIMTGVLFGMEILIYVLMKAFHTGMVENDLDYILFYIL
TPSLINVGCVLAARFAVLGECTVQRKSQALIFCILCICLVTATFHGLFLMTSCIFVIPII
VSIMFDSRRLTGGTTALSVLFMLMGACTASLFDNTWSLKYRILSGLMGTVLIVMTSTVCM
SLLYLNEEKNAIIRKSCRMNEEMQHALKRDAMTGLYNHTEFYKRLDQHYRECHVQSGQLT
VAVLDVDFFKRVNDAYGHECGDAVLIRLADVLMEYCQEYGEVFRYGGEEFAVISRRLSER
QMAERMDRVRKAVNELKFDFMPEGQLSFSCGIYEYQGDKMLAQEIFSRADRALYRAKERG
RNRCVCHSDL
>A0A4P6M0B2|diguanylate cyclase|EC 2.7.7.65|Blautia producta|TrEMBL
MNTDCKKDTGGKAGFIKDKNTYTLYKTDIQKRNYKMLFYVSFSLLFLGILFLTVNSFFHI
FNSGTKYIYLYWVGSSCCMFLLCLWKKQWILNHAIAVLYIYLAGIMVSMIISGTYFYRDS
ASAVMIGCIACMPILLFDKQWRFCLFDISICLLFIIFSFMAKDPSVALIDCVNAFSFCFI
SCLIGMYTIQLKFLDIRTKYMILEQLETDSLTGLMSRNAAIREIEKYYRSPSSGIGSLFI
IDIDHFKDINDTYGHLEGDHILIEVAHIIRDSFPETDCKARLGGDEFLVFMKNVEDTARI
QTYAESLNRNVQEGSFSFNKNLHLTVSIGISLCRECTSFEELYVQADTMLYEVKNQNRNG
YKIYDK
>A0A2C9DDP5|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MSAKRAACEKSDDSIADDTTMFDLAPVSLWLEDFSGVRAVFDGWRARGIRNLAVFLKEDT
ARVGEAMGAIRLLKVNRRTLELFEARDLDEISQKAAAIFGQDGLESHIAQLVALWHGDSV
YQGQCINRALSGRRIDVDLKLQILPGHEEDWSRVLLAIDDITEREAARRQATEAKDFAFG
LFDHSPVSLWLEDFSDLKAVLDRWREEGVADLAAFLQEDTARVGEAMGAIRLLKVNRRTL
ELFQARDMDDIRGNVAAIFGHASLEVHIDQLVALWQGETSFAGRSINQTLSGRRIDVDLK
LQILPGHENDWNRVLLALEDVSEREAARRQAAASEEFALGLFDHSPVSLWVEDFSGIRRL
LDEIRAIGVEDLRVFTDVHPEFVQRCAGEIRVLDVNRHTLKMFGAADKRTLLDRIDQVFQ
ADMLPHFREQLIDLWNGKLFQQREVVNYSLDGNELNVHMQFSVLPGHEDDWTLVQVALID
ITARKKAEAYLEYLGQHDALTKLFNRTFYAEELNRLDRNGRQPVTILVADLNGLKALNDE
FGHTAGDALLRRAGEVMAEAAARTYKACRIGGDEFVILMPLADAREGEAFAERLHKLVSL
NNQFYSGQELSLSVGLATREPGERMEETVKRADDLMYRAKRAHYAKTDRVSRTLTNIAS
>A0A5P9HCA1|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MPPIDVAPCTERLEPSRVLELADQLPGLIFQLHRSATGHLHFPLLMGSGIQLLELDPERL
AENAEPALAHIHEADHPGLMANIERSARFGSPIILKFRFVITEARWRWIAVRAQPQRVET
GVLWHGMMLDVSEQVAEEERLRALSDSDTLTGLANRRKLLSRLDEEISLSNRHAIPLSLM
MIDIDHFKAINDTWGHLQGDATLCELADCCRSLLREEDLLARLGGEEFALLLPLTSRQNA
ALLAERLRRAIAEHHFDDLGPGRITVSIGITEHRVGDARDTLLHRADASLYRAKHQGRNR
VVADG
>A0A1J1LPR6|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MLFGHLPMSAIALEQTLNQIMAITQQIHRPLELGDILDVTVKGIREILGCDRALIYRFLP
EGDAVIAEESISSETLPIIGQLIYDPCFQAKWVDLYRQGQISFIEDTAAKPLAPCYKQLL
QRLKIAANLVVPILLPPSPVETRHGASVPASSTLPNLWGLLIVHQCDSPRHWKPLEIQFL
QQVAIHVAIAVQCREPNQPIREFHQWQQQTLQSPSRRDAPKAYGMAEPRRVSTEECGCCH
SVDESLLKSSTPPVSISDLRGWDRLQTPIWIFDIENLQMWWANKAALHIWNATNREELLQ
RNFKDVSEATRIRLNAYLQQFQHQETVTETWTFYPEGKPISVRCTCSGIEIETGRMAMLV
EGITEVANENTPETLRSIEVLHHTSVMISLYTLNGVPLMQNPAALHCYGDTLHPNRADDN
MFVRHFVDPNIGETARLTAQSGAVFSIETQVYTLNGIRWHGLDVRCTRDPVTGHPMLLVN
EKDITEKQASLIERQRVEQELRWKEALLRSMTDTSNLAFFVVDNRTDNILYFNHRFCEIW
GIEHLERQILEGVLKNNDIIPPCIRLIADVHAFAESCKPLQSEDNRTVIEDEIAFSDGRT
IRRFSSQIRDQSDHYFGRLYIFEDISDRIAAQKALKVSEDRWQYALEGNGDGVWDWEPQT
HQVFFSRRWKEMLGFAEDEIGNTLEEWENRVHPDDIEAVYRKINQHFQGETEQYISEHRV
LCKDGSYKWILDRGQILSRSSLKSLPLRMIGTHTDITERKAMEETLRERETRLSLALEAA
RMGTWDWNILTNEILYSEQLRLMFGLSGPYDRSYEAFLEIVHPEDRRLVDQSVRCALSET
DDYHVEFRIILAEGAVHWICNKGQVYYNESGQAIRMIGVAMDITAQKRSEIDLRESEERY
RSVIAAMGEGIVLQQTDGQIVACNQSAERILGLSSDQMMGRTSIDSRWWAIQHDGSPFPG
ENHPSMVTLRTGEPQFDVIMGVHKPDGDLTWISINSQPLFHSHQPQAYAVVTSFSDITIR
KQAEEALKQQAERERMIYTITQRIRQSLDLDEILQTTVAEVRQFLQADRVIIYRFNSDWS
GVVVKESVEPGWKSILNLEITDTYFVQNQNKSYEQHTIKATADIYTANLHSCHLELLEQL
QVRAKLVVPIVQNQGLWGLLVAHHCSGPREWYSLEIELLKQLAVQFAIAIYQSELHQQLQ
FANQQLQNLAMVDQLTKIANRRCFDEILNQEWHRLIREQRPLSLLLCDIDYFKQYNDTYG
HSQGDICLQQVAQALQQAVQRSIDLVARYGGEEFVVILPHTDQEGALQVAEKIQEAIQQF
NQPHRASAVSQRVTMSIGICTLIPTLDRVPLDLINAADEALYQAKTQGRNRAVSRIL
>A0A7U9H690|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. KTE159|TrEMBL
MLHETEMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A727TKR0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:g,z51:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A128EX30|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MLSYKFSRALVAIFVLLFFSVATVVWFFIGGAQSSYVISPTEFQFRYIDDTPMGGNTKGR
VYTKDDGSVALECELGSAYRWPFCEVAISLSPSVTHGIDLANYHSMVIEAAYKAPAPDQR
LRVYLRNFNDAYSTTEDPVSMKFNGIEYNPTEEMSEIVLPLNSFQVLSWWISDLDIPLEH
AGPDMSNISLIEIATGSAPTIGQHELIIKNIRFEGVMVTEAGLFRSLTFIWLATATILLA
VKYLQSRRVYDLERRRANRLKAINTALKQQSETLSIMATTDALTGLRNRMDIYPELEKAL
ASTGGKNCTALCLDIDHFKKINDTYGHDMGDRLLICTADVLRDSVSTSDVIIRWGGEEFV
IFCPNRNLAQASFLAEKIRAAFETTDWPHDAELSCSVGVSSMREGSIAAMIADADDALYR
AKQNGRNRVEVFAESFIATV
>A0A128FB78|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MHLLRLCRFVCSVVVFVLGISQSVALAETDKDTIIVTNSHSWKPFAFSENGIAKGLLVDY
WKLFGEINNTPIEFALSDWNDSLVAMQEGGRKVHAGLLYSESRDEYLDYVFPLFEISTTL
YVVNDAEELKTQGVVPGMVVGVVRGGFEEEYLKNRYPLVATMGFDNNAALIQAARNGKIK
RMLVDTQVATYYLLQQDNPLGFVPIERMYKKMLYAAVPAGNELLQREIESGIKNIPPHEI
DRIKQKWLNTSRTTKIPNWLWPLVGSVLLLGSASYIILLKQAVKRKTRALKALNSKLEEY
AFTDSLTGLMNRRGLDRVFASKRVKSMQKRGQLGVLMLDVDHFKQINDKYGHSKGDEVLN
NLGRVLSNYLREAVAISRLGGEEICLLVPVEDLHDLEVNADYVCSFIVPQVSQEGVGLSV
TASVGALLVDKDGKETSLEALLHHADRLMYQAKEAGRNRVMLGCLSSQQHHRYSSQVSA
>A0A1V6BWC3|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin133|TrEMBL
MQMKNAGKKKSNYFFIVISLFFFLFMIFIFWNLSSRMFENAVVMIAMDNTQKLRSALTIV
NDNSEAAAFTKDVNATAKIIKTESILKLFSLNIYSADKKLLYTWGRKIDVIKNLSVDDLR
DKDIVYNKTYITNSVKLTYQTIFSVKKKNSVEAYVEILYDLTSLKNALFSERLSIYVFVI
LVNFLITMFLCIMILNLRMHLDKKEKQISTLSTIDDLTGLNSKENFTKLVKKEMERIERN
GGKLTLMIFDIDDFLSINKNFGDEFGDLVIQTLSKIVLDNFRTFDIVGRFGGDEFAVIMV
DSDLDEGYIASERCRKSIEDNKFYEGTNEIAITISAGLSTIAIDKNIPLEDKSPNKTGIY
RNLIFTALNNLAIAKKNGKNRIEK
>A0A731V297|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar London|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9H9F8|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. TM-G17TGC|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A380AH03|diguanylate cyclase|EC 2.7.7.65|Shewanella morhuae|TrEMBL
MILPIIPDNELQRLAKLRALNVLDTDTEERFDRVTRLTRRIFSVPICLVTLVDAERQWFK
SHQGIEATETSRDISFCGHAINYEGVFIVNDALNDPRFCDNPLVVQEPFIRFYAGYPLTI
SDGFRAGTLCVIGTEPRQLTIEEIEILTDLGKMVEAELLSIVQNTLDPLTTISNRRGFEV
LAHQALASCRRTKMAATLVFFDLDFFKEINDSFGHRKGDQLLCDFAHILLTAFRESDVIA
RMGGDEFVVLLSFVHKDTVNHAIERFKLLLEQYNQHHQHKLSTSIGIAHWTPDSELGLDD
LLDCADKAMYQDKAIRRKS
>A0A7W6D6Y7|diguanylate cyclase|EC 2.7.7.65|Hansschlegelia beijingensis|TrEMBL
MTARVLVVDDIPANRKLLDARLSAEYFEVATASDGFEALDVCARAQCDIVLLDVMMPGMD
GFEVCRRLKTDPKTHHIPVIIVTALDQPSDRIRGLEAGADDFLTKPVVDVALFARVRSLA
RLKMLGDELRLRAQTTREIGLTDALMEAVNDPGLGGRVLLVDDRENSWRRISAALASSQT
VDVETSPQEALFRAAEGEYDVVVVSLGLEGFDALRLCAQLRSLERTRMTPVVLVASPDDN
ARVLRGLEVGVNDYVIRPLDPAELTARIRTQVRRQRYTAQLRSNLQASMELAITDGLTGL
HNRRYMEMHLQSLLDQAAARQRPLSTLVVDIDFFKSVNDTHGHDAGDDVLREFSRRLKAS
VRGIDLACRLGGEEFVVIMPETDGAVAQIVAERIRSKVAEAPFVTSGGRAAIDVTVSVGV
ASFLGADDASTLLKRADLALYRAKASGRNRVVADAA
>A0A6N3R3I8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELALLAQAME
HDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTMLLI
SWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSVIQV
DLDHFKAINDRFSHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTEAAE
VAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEEAGDYDFEQLQSLADRRLYLAKQAGR
NRVCASDNA
>K9NM17|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. UW4|TrEMBL
MSLHAVRPRILGFISEDASAWLVALLVLLIGGVLTGLLAWSTLNLFHHQLRQRFQLLASE
RYSRIEERFEDQEQRLDGLRRFFANSGSVSRAEFDGYTQPLLLRTQAYSYAQRVTRDERA
AFERRVRDEGVNSFTLRELNADGQLQLAGERDEYVAVLYSQTQSKLGAPLGYDLLAQPLR
RATLERADRRGGMAVSQPMHLVSIEPAYARGVLLVAPVTQRTGQAHNATKPYGYVMAVIS
MRQLLADGLPEASRDYLSVRILDLSTDDRHEVLFESPNPPAVSELSATRLLRMADHHYQV
DIRPSDAFVQANHSSVTSLLVLGGLLSLLLSALLYVLVSQRQRALRLVEQRTQELRDREQ
ELRGTHGQLRGVLNAATQVAIIATDLRGVISTFNAGAEQMLGYSSAEVVGHMTLENLHLP
RELAGRSAELSARYGKPVPTCQAMLVEGDVEGGHEAREWTLVRGDGSHLMVNMLATPVLD
EQGLWVGHLAVCIDITERKRVHEALAARDLLLKKLSAHVPGGIYQFKMEFDGRFSVIYAS
DGIRDIYELEPDVLLLNAEAIFTRIHPQDTTRVRASIRASAETLSPWREEYRVQLPLRGL
RWVRGEATPEELPGGGVLWHGYISDISDMKRVEEELRALSVTDSLTGIHNRRYFQERLST
EMVRVERGGGDLSVIMLDIDHFKRINDLHGHAIGDRVLQAVCERIGHRLRRTDVFCRLGG
EEFMVLCPDIGGEHAYVLAQQLWHSLRSSPIEGVGTVTASFGIASWRAGEGADALLLRAD
SGVYAAKQAGRDRVEEEMN
>A0A375BXD0|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MTQRFPTLHRWSGQAWRLLARRPHRFVLVSFSLSVMLLLLLLWRGLQLSQGREIESLRHM
QAVRAQSIDALLQREAERLLGVRNVAEHLLQIQATAPGKPDAGLRAALARRDEPVWPVPA
HDAAAVYGVSAAALRGLDGFARNPARLEADVVVARALSHLLSAAPQDSGIRRRMAYVSRN
GVLAAYPSIPEANVVSAVQRLAAAPYFHDSLPSRNPGRRVQWRIAPASAERNQVSLFLSV
PVYADGDVRGVAILELPQRTLDDQLSSAPFHEASSYLVDREGRLIGASARNVRAGETMQA
ALSGPWPAATLDAVFHAEAGLLNDAGGSDLMFRRLREGGLAMVDEIPVNQLWLASAARLS
GVIGAGAAALGILLCATLAVVHSLFRHYLARGEALRTLAETDALTGLANRRVFAARFAAE
SARCTAEPRPIAVVMLDIDHFKSINDRWGHASGDVVLRAVAAALRSGVRKDDLPARLGGE
EFAVLLPGTGVDDAAAVAEHLRQRLETLSCEPAPDAGSNEPIRFTASFGVAGIEPGAPGN
LDALLRAADQRLYEAKANGRNRVVAHQQDSAGASRGQA
>A0A6N3RBK4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MYSLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDV
GPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLI
FLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTG
LYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHFERVL
DGGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGSYLCLFDVDKFKNI
NDTFGHLLGDEVLMKVVKILKSQIPVDKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVH
FQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A399EGY4|diguanylate cyclase|EC 2.7.7.65|Calidithermus roseus|TrEMBL
MQRRVIDAMTPDPLVVEGEVSVAEAARLMNQHRVGGLPVVTGERLVGLLTSRDVRAAHPN
RLVLDAMRKDPLTIPPEASLFEAFERMQEAEVERLLVVRAGKLVGVLTKGALLYSLGASQ
DPLTGLSRADRLRHTLESYLQGGLDPTLVFADLDSFGSLNKAHGHVAADRALRALGRLLG
GFARAHGGEAFRYAGDEFVLLFPRPRGEVLPLLEELRREVGVLKVEGLPPLALSLGVSGG
RRGPGRVPENPAATADDLINLASQASTRAKGSPQGWVEAAESSR
>A0A071M1E0|diguanylate cyclase|EC 2.7.7.65|Mangrovibacter sp. MFB070|TrEMBL
MFAKLTNIKNPQKLVTLCFTLVFLGASLLVWREGVMLEQAYISDQRNTLDNIASSLDKQL
QHSVDILFFYQQAMEFSLDTPFITNSTHPSLKAFNRERHKPWWSISYDQRRTIPVFGVSE
EFVEQHSDLMRNNRALDRELSAALELSYLLPLSRYASTLQFRTWYISRAGMFVTSNGHKL
DKSVQTTFRRMLSRPFFAQQSPANNPDRAVCWSYYQDKTNPEYQVVTASVPLDYEGYWYG
VIGMDFTLDVLHGYLKGIAEQHSTDNGSVYLLDSKLTALTSSQGRHGEHLVMSPVDQARL
AQDMSSNTVGALRMQNRFITWAKLDSFDGVLIREHNLYQGLRGDFGHIILLLVFVWVMFT
VLLIGTWYFIRRLVTSMSVMQSTLSWRANYDTMTRLFNRGAFIDQAQQLSARCRPNSQPF
SVIQLDLDHFKSINDTWGHQAGDKVLKHAAAIISNTVRGQDIAGRVGGEEFCIVMPGASI
TDAAQVAERIREKLASKPVVYSAEVVIAISASFGVSSSTEKGDYDFEHLQSVADNRLYAA
KEGGRNRVCAED
>A0A8K1ISI8|diguanylate cyclase|EC 2.7.7.65|Phormidium sp. PBR-2020|TrEMBL
MESETSPELLRQELAQLRLELEILQREKLDLEIMVENITEHADAIEVELRARNQDVQELN
ERLALANKELEQLASVDGLTGIANRRRFDITLEREWQRLTRDQKPFSLILGDIDYFKRYN
DTYGHQAGDECLQKVCQACHSCAKRASDLAARYGGEEIAIILPDTDSIGAMYIAQEIRQR
IRKLKIKHDASPIGNLISMSLGVATIIPQTQLKANVLINQADMALYRAKQNGRNRIVLFH
KSL
>A0A378KUD2|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MALVSLEGRWLKVNKSLCQITGYTEEELLQIDFQRITYPDDLQTDLNYVRQLLNGTISSY
QMEKRYICKNGAIVWILLSGSLIRDAHSAPLYFIAQIQNIDAQKKAEHELVRMAYHDALT
GLANRKQLEQSFLLFMAYAKRHQCSIAVLFMDLDYFKKINGTFGHDAGDLLLIEVASRLT
ASVRSSDIVGRQGGDEFLIILSDIVHEEEVHTVINHLFHAIQQPILIKEQTISISLSIGV
SLYPQDGSDLDTLIQHADAALYQVKSTGRNNFKFYTPFH
>W7P7P5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MTSQSWRSLVHRKYQLSLRLFLFLNATSAVFSVTNPLNSVRLFSAPLIAIFSISTGLFVW
HWRKRARKINIPVVSGIFGILWAWQIVSKFALITHDHATYLLIALLTVLFIGTLAFASNI
KAFTLHSLPTFIVCLWLSDHDIWLRMTYSFALPVVAIAIHNILQRRNDRFAQELLSRLLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPTVENGEHFVLLMDIDHFKAYNDHYGHMMG
DQALKRVSAAIRDAVRSRDIVARFGGEEFMVLLTNISLEHARQTAERIRQKVYDLKIPHL
FNESVATNVTISIGIAIFEDEDVEGALEKADKALYEAKHMGRNNILLSEEIQTA
>A0A2X4UFY4|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MNAILLGLLLRKPAYATPLGWLTTYLGMIAADLTTGEALPLVMWLNACNMSLIATGYGVM
LLLPQSQRRMGKPQAILYMFTASLSGAAVASTLSILRNDSLYNNTVITAWLAWFSEQFST
NLLLLPVFLAAPRLKQLLRMQINWPLRAGMPLLALLFSLIFSVYIGGPGAIAFPIPALLW
CAVRYQLFTVTLLTLLTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPL
ILASSIAVNRKLMRRLEHSANHDFLTGVLARSALTRKAGELLEHKYKSKEAVSLLLIDID
HFKLINDTHGHEVGDQALANLRSYCPARTAPRSAVWSLGRGRFCDYAAARAGGAGGGIGG
AFTATGAKNRPVSRRQSAAESDHQRGVASLAMNEVKSLAQLMNMADIALYRAKSQGRNRV
ESFNAVSGNSVGHIVFK
>A0A679JYV5|diguanylate cyclase|EC 2.7.7.65|Hyphomicrobium sp. ghe19|TrEMBL
MPLDYHSLLTAFVLSGFGLAITFFVSWLVSRTEHFLIAWKLGVSFMALGVLVYSWYANTM
SPVLGAAGYTILLTGLAFVFGAGREFRTGVFPWRGVGIIAVTSSTAIAVPMLAGYNGASI
IVLNIAATVILLVTARDYWRGRAEARLAITLLTVLYILTGLSFVPCAILLLDAGEWRLSQ
IPSNWAEDLNIAVCLTTLAGIGALSLALNQARLARGHKRDAETDPLTGLLNRRALLSHVA
DIEGPAALVIFDIDRFKVINDVHGHLAGDEVLRTFGEILKLSSPSKGLAARLGGEEFAML
VPGASLVTAALLADVVRMRLAKRNFTGNGGSFNSTVSAGVSCSEDAATDFETLLRDADDA
LYAAKRNGRDRVAVNSGKIEFLAHIRPLQDGQRGPIDLVRLKTG
>A0A833UVC0|diguanylate cyclase|EC 2.7.7.65|Burkholderia gladioli|TrEMBL
MHVDLLTLYFLAIGTLFASAGLTFWEHQAHPHRSKALRILAAGYTTLGVGCAVVLVRRAM
PGASGAVLSNLVILGGYLLILGGVAALNGRRATRVAIGVLAVDALAWAICWTRWADVMWY
YISALPIAFVSGMTTRELLRCEGMKALQARRIAILVTGLHALFYIARALVLPWLAQRYGM
PLVMLASQATLYEGVLYSVILPMTLLRLIREETHGRLLREAQTDYLTRLGNRRWFFEEGT
RAIQAAGGKLPFAVLALDLDQFKRINDRYGHHTGDEVLKSFAEVARTVLGSETILARIGG
EEFAALLSSYDASRAAELGEYVAQRFAETIAAKIDGIDIQATVSIGLARYEANSVPALAE
MLAAADAALYTAKSLGGNRLVQG
>A0A447M980|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MFPKIMNDENFYRKAVERAVAPPASQNEQQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPLGGGWWLLLVGWTFVWPHLAWQLAAKARDPLSREIYNLKADAILAGMWIALMGVNLL
PAAALLMMMCMNLMGAGGPRLFFAGMALLWASCLVTLQLTGLPVATRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRQHWEILLRDEFDHCRRHHRE
ATLLIIDIDHFKSINDTWGMMLGMRRLSL
>A0A1V6HW58|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin051|TrEMBL
MPRSENRSSADPEIHILGAEELEVFLQRRRASPVLEMSLAANLAAVLTKANEFVPSEAGS
ILLDDPREKHPDRAANLLTFVAAFGSRADRLIGQRLPASRGVAGHVYLTGEPYHTSDSTG
DRFFSGEVDAVTDFSTQSLVAIPVRIGHDVCGVLELVNRHGAEGFNETDRNLLHIFAGYI
AIAIENILDGRLAQELARRDNLTGLFNDRYLHEGLERAIATARDEGSDLALLFLDLDFFK
RVNDRHGHLTGSQVLRDVGRLLREQVTVPGAMLARYGGDEFVLALPRLQLGEVVALAEQL
RETVVATTFSAEPGEIQPEAIGLRGITVSIGIATLHRHVPPEADLQTAKSTLLRLADVAM
YVAKETGRNRIAVAAEFVPAGVPLTPPRAR
>A0A1H6F5L4|diguanylate cyclase|EC 2.7.7.65|Thiotrichales bacterium HS_08|TrEMBL
MNVLIAEDNITTRLMLSEWVKSWGYTPVVATDGRHALEIGSIRDAPWLAIIDWMMPEMDG
ITLCRKLKQQKNCPFIYSIFLTSKNSIEDSIMGLNAGADDFLTKPVRPEELRSRLNAGRR
ILEYQEQIEERNLHLQALLEAMPGAVILKDAQGCWLEANEYALRMFNLDENTAYHGLNDE
ILAEQPHAFKQALNTLNINDQKAWEQGGFYREELELPGNAYAEKCWFDIVRTPLFHNDGR
RKSMIVLGYEITKRKLLEEKLRREAWYDSLTGVFSRHHFQEHLDKMMSFSRRTGLPMSLC
LCDIDSFKQVNDQHGHDVGDQVLAKFAELILHQLRNSDVCGRLGGDEFCIALPGTRAEKA
VSCLRRIENQLRAQFFHSYEGIAFQICGSFGVVEFNNSKLTQRELMRHADQALYRAKKNQ
NNKILIYR
>A0A855WQ07|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri|TrEMBL
MDNECMHMLAGQWQHICQNYSSDDLVHAFQFIQDNAPILVEEFYKNMLVEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDEAKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYS
QGGDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGMQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A5I0BMZ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Koketime|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGIVDALQNITEVVHDVRTNRNFSRRVSDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6N3EED5|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MLERGVLLAFGLPLMIASLLVTADVFVRSVQKISVSRPFKYFIIGILTFTHLYFILSFSM
NSVGFICYQYTTAFIASHFFYGDRGKILILITPCMVVFYLLFVGFSDIGKAFYLPLLGVG
VFVLDFLLSKIKPLRPQQQFYLMYFLTCLISPRFSMLVHHTTTYDWEAMLAVLVGSFVLL
GGFMWLHRLIEGEEYQVLAELANSKIDALTGCFNYGTYNHDLLQAVSQKKTVTIAMIDLD
HFKKVNDRYGHIAGNELLRTFASRTSTFLEAHFAETFSFYRYGGEEFCVVIEGDVKEKTV
AAMTTLCQTISSSMFPVANFEKGTMSLSCGVEASTVCHGDILAAVERADQALYLAKQSGR
NRVCTLPET
>A0A377KS36|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MANTLVVNTLANLGAIIINIYLLFKISDGFVGQGTFKAKQIAAAIACETVVGMLMMNFSY
VVYETRFDLRFLLYAFSMKYLGWKVTVPTMVNLALGRFLFEVSKSSWLNLYLTFFLIVTL
TFLHAWAKRRFTDKQELFLSITYLIVISFLFGFYLTGDIQKTTLIYIIYGILAYTLAFFL
YSIVNDMQRILALVKIDDLTQLNNFRKFQDDRQRLDTTEVDLSIALIDIDHFKNYNDRYG
HRAGDVILQEIARIFSTYCTASNPVYRIGGEEFAILIQGDAQAAAYLLEKIQKRIRYQEI
ILDAGDSVSITLSIGIAQRQKGELLQQTQERADQALYRAKRSGRDQLCLY
>A0A0B0HP96|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus sp. BCO1|TrEMBL
MQQYNLEIPSKSGKVYLFQIKNVPIIVDGKKVGIYGIGRDITEQKRAEEHIKYIAYHDVD
TGLPNRLNFTNIVKQAIDQAKETGNTLAVLFVDMDRFKIVNDTIGHYGGDEILKQIAERI
KNVLPEGAHLGRFGGDKFSLLFTEQVDMHTVVEWTKKLLQHIAVPIIYEEKEFF
>A0A8G1JAN3|diguanylate cyclase|EC 2.7.7.65|Bacillus pumilus|TrEMBL
MDSIVLHFIVIMSVSGILSVILSIIAHANRRRYIGCQLFMYMSGATAIYIFGHTFELLAS
TPGQIMFWVCFQYIGLPFIAPFSLMIVLQFTGFHQYFTKRRVLLILLIPTLTTIMVFTNS
FHSLFYRSITMNPVDGFLLADFTIGYWYIIHGVYTFGCSMLAIFMLVWFLRVTKKEYLKQ
ILILLVGMLLPITTSFIYLLGVTPLHIDPVPVVMFLTNALYLWAIMSFQLFKLSPIAMER
VFEHMSEGVLILDRYRTLIDYNPAAASIIPALSNKKGIGYKIDDIFSGIIKDTAFIQWLR
SPQDHSQYDLMWKKDKDQSSYYHLTASSLFNRRGEIEGRQIVISDVTEQRLLQEELERRA
YIDGLTNIFNRSSFIERTQMILEEDAQDTAILLFDIDFFKQINDTHGHHIGDEALRHVVT
ICQQHLQMDDLFGRYGGEEFAICLPHHSFEEACHIAERMRHSFETSFFETDEEKVRVTAS
FGIAHTAYDPNVLETLLFEADQALYMSKRQGRNRIYASTGAGYMLYEEHDLPPASH
>A0A1G4FHN9|diguanylate cyclase|EC 2.7.7.65|Sporanaerobacter sp. PP17-6a|TrEMBL
MHEGNFETNGVIQIVMNREHKICYSNIEYRMTYDYLKELNILENLAVDLPIQYTSDNYFV
NIDGFYITDQLYYIIVINPKNYKCCNCNKALIDTATGLYNRNYWEQMNSEFFCHPELKDI
SVILIDIDNLKKINDNYGHLAGDKAIEIVGQAIKRSIRKEDLGIRYGGDEFLVLLHKQGK
KGLNKVIQRIEKEINKSTMEVNADIHVSAGIACSEYFDNLKEMIKTADKDLYKEKRTKQE
EKRIEVNDLKNLKQNIEKMKNELDRKIPKDGSNASSKEVLKLSRELDRLIVKYLNNV
>A0A1A8THE2|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MPSNSASKINQYFRQTIPMMVKNNVPITPPYYTLWYNYTTGELPKLTQRIDDVIKRLGHC
DSYMCDKLLDEFIVNSAEERLVEMQNNIHQVVTSIGTSTATAMSDAQDLNQSLSKDIQIM
AQEASQADSPAAHKMVSIARNFMDKTETYRTQLEKQNAEIQALKAKIAETEKQMFKDGLT
EINNRRKFNEDLAIYTASADNTCLVMVDIDHFKPFNDEYGHLLGDKVIQSVARTLETSCA
QTRDAQAYRFGGEEFAILLPNADIKSAAKFANDVRERISRLNLTNKKTGQSLRPITTSLG
VAQFQPGESLETLLERADQHLYAAKNAGRNCVRPVITALAS
>A0A009FXM1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii 348935|TrEMBL
MLAEQWEQNCQNYSSDDLLHAFQFIQDHSSVLVEEFYKNMLLEEEASQYFTDELIQQRLR
DTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRKIFELLSL
NPQPNMLTTCSYIVQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAVQKDKQRS
SLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIERIYQIDT
LNQAVLECTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLLNRRYLNT
IISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYIQGSDYAF
RVGGEEFLLLLVDSDERRALNIAENIRTYVEHGLINTSQGQQFRLTVSIGCALFDGHPDY
QRFLDAADAALYMAKNTGRNRVYLAQPSQIQGTQKASV
>A0A1A8TC99|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MMLRYLLLFMMALLTGQTSAASGQVVITNIHYYQEQAASPLSLTQALQRFAQGDFSLFEP
PTLTVGQLSLFEHPALTFGIRDRGVWVRLALENQTGAIQARRLTAGMTWLEQVDVFYISS
GRTQTYTGGDGLAANEHLLPAVGIVFALDIADGQSEVWLRVQSLDPITLPIRLESLEQAQ
QTDSKAHLTSGLLYGILLALAAFQLVLYRILKHRNALFYTLYVGTFVVMNFGYTGYGFAW
IYPQNPVIQNYSTLFFMVLHAIFGLLFMRSFLKVRKNFPRLDRGLKLYMLVGLLAITTCT
LAQTHLLSALWAFGYITLTTLIMILTSLISITKVKDARYFLLAVCCSMAGLCVTSLSTLG
LMPYSQLGYHSAEIGVVCEAFILAIIVTNRLKVIENERITTKFLATYDPLTKLFNRHAFE
QMTTKLLQQAEHYHAPLSMAILDLDHFKAINDNYGHHVGDMALKHIADIMKHAARPNDIV
ARWGGEEIVVLMPNTRLTDAHTLCEELRETICNSPLVTADDESIVITASIGLASTKDYPT
FSLLFRAADEQLYLAKKLGRNLVKFVLPSKRGSDLNEA
>A0A380U135|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MGSLLLICHFAFRAPSYLLWLGLGYIVPSFSVAAQSFMSNKQLALSAPILGSMYLFGAWA
SAYAMGLRKNANARPYWCLALVVMALLSLSYYSYVDDQLWIRMLILNISIALVESLVLFS
MFKHYQGIDLLNKIVDFSYLFIVLYTFVRGMIIFLFLRNIEADMLANSVWWLMMLAASII
LSMWFAIVLLGTLVRDITNQLNDEWLRDPLTHLFNRRGFNEAAKVKLHCLSQQSYFLLMC
DIDHFKKINDTYGHLVGDQILQQVGQIIGQNVRDHDLVGRFGGEEFIVLLQIDDPTLAYN
IANRIRLGIADAQLSSKSIAVTASFGLAAVHQPNLKYAIHDADQLLYQAKHSGRNQIGFE
PAQSILDASH
>A0A1A8T5X1|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MQDVDISISKRLRDKVWQGLCLILGILAGLLAIWNFFFNSNALYLAVAEVVLTGFSIYIF
FHVKKWPKITWQQYVYLLLFCLLVSYAVWSRPLSNALIVWPMFLPILCYLTLGIRVGLSV
SLITLVLMLIILTLKVEAEGYQNTVSTRLNFFFCYLCIMGISHVYERNRRRIEGDLVNLA
MTDTLTGVKNRLAFKQYLANFLKSHTLFGLMMIDIDHFKKVNDSYGHDVGDELLRQLTER
IQNMSPQYQLFRHGGEEFCILLAGDKASLMAHAERIRATVAQQAFCLDERDIAITVSIGV
AINEEVSSSSELIVIADQRMYCAKRQGRNCVVAEGELSNA
>A0A1R7Q9F7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MQLLDSPIFELSPIAMWLEDFSEVQKQFDLWRSQGVEDIASFLLEDKSRILSCAHKIKVL
HVNPQTLKQFEAQSFEDLTANLAQIFKADMSSTHLNELVALWNGETLFENTAVNYTLTGH
RLDIRLRGTVLPGHEHDLSLVLITTEDITPYANAQRLEEKSRLIAEARFQYSPTSLWVED
FSRVKARLDHLRRLGISDFKTFLDVHNDFINECLRDIMVTDVNQATLDLFAARDKDHLLK
NLHKVFQNETQQTFRHQLLELWDGNIQHNCEAVNYALDGSIRHVLLHFAVFPGFEDDWGM
VQLALTDITARKKAENYLEYLGKHDVLTKLYNRSFYSTEINRLERNNLRPVSCIFLDMNG
LKAINDNLGHDQGDSLLRRMGNTLNQLIENTQYSASRIGGDEFVVLLPAADEAALNHCIE
SLHELLMVDNQFNNHQPISVSIGTATSQPNERVEDMLKRADTAMYEHKKTYYAENDRLVS
NYNPANDQ
>A0A7T0DXU3|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MMNDENFYNKESIREEWHQNLSQDDSHRTGIRFARRVRLARMVGLAAMFFPIAGVLVTQF
LAGGWWLLLVGWAFVWPHLAWQITCRAPDPFRREIVNLKVDAVIAGVWIGLMGGNALPTT
ALVMMIGMNMMGSGGCRLFLAGVTMTLLSAVVTLSLTGRIVTFSPEPLEWWLTLPVFMLY
PMLFAWVSHQTAVRLAENRHRLELMSTHDGMTGVFNRRHWETLLRNEYEQCRHNHRQTTI
LLIDIDHFKGINDTWGHDVGDEAIIAITRQLQMTLRSGDFIGRFGGDEFAIIMSGTPAEN
AIAAMSRVHERLKKLSLPGAPSERLRISVGVAPWSTQFGHYREWLKAADIALYKAKNAGR
GRTEVAA
>A0A4P7LGH1|diguanylate cyclase|EC 2.7.7.65|Cupriavidus oxalaticus|TrEMBL
MTPDTAPPRHQAATVHSAAPRRWQPLLLAAAGYFALAAAGLWLARLPGNVAAVWLPNAFA
LGLLLHRPRRETPWLLAGMLGANLLANHAAGDSAASALMLAGANLAEILCATGLLRLLDR
HAGLVRHGPLASFAVMLAVAGIVAPALGATAGAAAIVKLHGTPFASVWWTWWQASALGMA
LLLPMMLSMTPARVRTAFARPVLVPQAGLLALCLAIGALAQWQGHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLSLQALMLVGHGHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
GSEKRFRQAMEHSAIGMALVGMDGRWEIVNRAMTELLGYSGEELRAITFQQVTHPDDLSD
DLRQAALLVDGKIESYRMEKRYRHKDGQYRWALLAVSLVRDEDTGAPLHYIAQVEDIHAR
KLVQEELERLSRRIQLAVEAGGVGIWEWDFGSTAITWDARMHALHGTDPAQGTPQAEQWI
AMLHPEDVSRVSTEMRQAIRGAAPFDTEYRILRPGGAVRHVRAMATVTRGADGIAHALVG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDANMHVTFMNPIAEQLTGWTMCSA
GGLPLEQVFRIVDEASGDPIPSPVESCLRTLTPAYLQDGAVLQSLTGERHDVQDSAAPVL
TAAGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
RAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYLIRNHVRPDDLLARLGGDEFALLLKDC
TVDQAEQVCQGVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPAGAGRGES
RHIEILVRMVDESGDMILPGAFIPAAERYDLMGHVDRWVIHNVLHGYGERLRAVPGLSVS
INLSANSLGEPFLLPFLHAELDASALPASRIRLEITETALINNMAAANRLVSEMKRAGCT
VSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVKTVA
EWVEDERTLEALRAIGVDFAQGYAIGRPTPLDAFLQACGPRGVEQRQGA
>A0A485M0Y3|diguanylate cyclase|EC 2.7.7.65|anaerobic digester metagenome|TrEMBL
MKTAIMVKESLDEHLSPIISSVFDSVQVIHSDEDFLSLISMDPPDIILVDRTCLKEEKSR
IIEEFRNSTLYGHLPIVAVYSEKDIEDPAALEIPIDDFIVLGSSELQIRRRIEFIAGRSV
REKDINPLTKLPGNESIIRCVQRMFDENSEIAIAWVDLDNFKPYNERYGFSSGDEVLLAA
ARIITNAVRGAGHENIFVGHIGGDDFLFLCPVAGVGTICEEVISRFDTAIRNFYNEEDLE
QGGIVSKARNGEIRKFPVITISIAVVINERKRYRHYGQAFQDAKEIMSYVKGLEGSNYMI
DRRGRHR
>A0A380B602|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MTYVASIPSLFSDACITYATLSVSYFALSKNAPFSYQSEAWKRGLFGLLAGLTTLFLNQN
RLELAGNVHYSFAMIPMILVTFYGGALSGLVCYLTSLALSGGFTVDNLFIGSIIIPLLLS
RVWLRKSNRVFYLTIGVIALYRIAVVWFWVDMWTLWLDVLLYQVIAALCLAICYHALNFK
ERHIHAYFSMRDKATTDSLTHISNRASVDYRLMLQQAERRPCGLMILDLDNFKRINDTYG
HLAGDLLLTQMGQLLQNSVRSEDFVGRYGGEEFMVITASYDPKIIGGVAERIRRSVETTI
FLLDEGNETQITVSIGASLYLPGMAVDKAIEVTDEALYEAKRGGKNQVVCSRLMPFSPLG
AGFRQQ
>A0A231HMN4|diguanylate cyclase|EC 2.7.7.65|Pusillimonas sp. T2|TrEMBL
MLLDIFRREWALFNDFAGPGVPERVERIVTQQADSLASQFYDTMLKDPQAQQFLDHEQVR
TRLRASLILWLTRLFGPVSAEAADDLYADQHKIGEVHARVDIPVALVLRGARSLKRAFNA
YLDRVAPDDDAFKLSACRFFGAKIDLAMEVMSQAYASSSARKARSSEAYRLFSITENLAT
EKERQKAALLDWESQVMYETVLGNASTRLVRVRESEFGLWFRHKGIHAFQGVPEADVIAQ
SIDAIDNVCLVALETEGAVDAQGRSDVVREIRNHARNIQLHLGSLFARSLELESGKDVLT
RLLNRKFLPTVLAREIEHSRKSGSGFAVALIDIDHFKRINDNYGHEAGDQVIQQVAAVLS
EHCRGGDFLFRMGGEEFLLVLVDLDIQQAGLLCDRVRQAVQKHPFLIPDGTVLAVTVSIG
LASHTGHPDYHYLLRQADEAVYEAKANGRNRVATHAGGSGVA
>A0A1C3J3I1|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MSSINFESTYGVITIQDMNVVSVDANYARIYGYQSPEELLSDIDSFLDLISEEYHVLAYQ
NYLETVSGQRDPQVHTYTNIDRNGREFTVFSIDHVTEWQGRPALQVTVIDLSPAIQLQNA
VREQDKMYHDMIMQSGQGILVHRDFKPLMVNQSWVKLQGGSSIEQVLALDSILDLVPQQN
SDGIYKHYQAIVSGELSGTSTVVENIGFDGVHRFFNIYDNAITWKGQRAVQVVLEDVTQK
VMLEKQLVHQANYDEMTDLLNRRAIYEWLREHMFSKNYLVCMLLDIDDFKSINDTYGHMV
GDEVICALASITKRNAEKVGGVAGRWGGEEFIIFIPNAPLETALEVSEEIRQQFNQVEFK
VGEQIRFNSSVSIGISDSRACEDGVTIDALVNLTDQSLYRAKANGKNCVDGDVVAL
>A0A1C3J1C6|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MTSSFVTSSIFRFCFPLLLLAILLAGMNNVILVTDSNLGFASNLPYILLSVAVLLCHTFK
QGRMAMVSLTMLVAYLIIQVRLQTPLNTGTTLLELSLLTALVPVTCLLVYAFPDNGVNSK
SMFLYALVLVLFTVWAQLIVSHFQSGGFESWSEGILFIVNGFSRLPFVLVLYSLCLLGLT
SILVLVYNRAIDVVVYSAILLSTSTFIFFDVQYISSTMFSLSGTLFIIYVVSASHDMAFN
DRLTNIPGRHALEVDMKHLGRKYSMAMVDIDHFKKFNDTYGHDIGDDVLKLVARILSETT
GGAKAYRYGGEEFTIIFKGKYSEQVKEHLQVLISEVQNYDMTIRNSNDRPDDHEAGIKKR
GQSNKSTEVVNVTVSIGLSDSRTTKQPVEVLKLADNALYKAKETGRNKLCVDS
>A0A8F6M7M3|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRSGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVASDVMSQADIACYAAKNSGRGRV
CVYEPQQSQGHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEVIEEQAFRAGLVDPALSKALDRRVFSEFFQNSAQAVASKGLSIALPLSAVGLLNTELI
DELLEHLQRSPLPPRLLHLTIPASVFKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGVDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A2X2S3R1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINLLPSTALLMIIC
INLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPMAFSSTQLSVLLSLPVLVVYPLLFAWV
SYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQRDATLLIIDIDH
FKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTSASSAIAAMSR
VHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAKNSGRNRTEAAA
>A0A336QPQ4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFFPIASVLVAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNFKADAILAGM
WIGIMGINLLPSTALLMIICINLMGAGGMRIFIAGAVLMTVSCLVTLQLTDISVAFSSTQ
LSVLLTLPVLVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNE
FDNCRRYQRDATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGD
EFAVIMCGTPATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAEIEHYREWVKA
ADMALYKAKSSGRNRTEAAA
>A0A6M1DNI0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLMWMLLPKETTLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTFSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTDIPWLPFLMILLPANMMTMMMYAFRAERKNISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLSMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVYMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTRQCHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINNYQFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQRHTITHNPMLMIARGVASPRIPETFSFWIISLRLGTAE
GEVIEDQAFHAGLVDPTLSQALDRRVFGEFFQSAAPAVANKGLSIALPLSAAGLLNTELV
DELLEHLQRSPLPPRLLHLTVPSSVIKTNPTQAVSALHRLRQYGCRIVLSQVGRDLELFD
NLKFHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A7D6WRM4|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHALLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIAIGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A378ZYR0|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MQAHHALKLLRRHAGLINVHLAVLIAHWTCRVAFLEVPLELLFSVPAMLLGLSGVYAVFT
LTLAAAVVRYPGSTYLRLWFAVFLLASAGSTCIGLRGTVPLAVSDNVGFGLFITALGFVW
LGMRSFFGRYVPYLLPIMAALGVVPLSHFFDESQDLAALWRIVYALAFAGFFFLLTASEL
RRSIREEGLPSARAAAGVYSSFSFVHLAALPLPFLFPVRFDGLIPSSDWLFGLLFLSLMH
TVAAVFLGIVLSNERMAKAMRYLADTDELTGLPNRRAFLRRVEQSLASGAGGTLLIADVD
HFKQINDRYGHQCGDAVLKSFAAMLEQLAGERLFAARIGGEEFGIFLPGLTGPHLDLLAA
QLCRAAAVLQMEHGGKVIPVTISTGVADTSGSNVSYEQLFAEADRALYLAKRSGRNCFRR
LPQIRLVHEAGSGESGETSDGERQLA
>A0A8B4QEL1|diguanylate cyclase|EC 2.7.7.65|Kurthia zopfii|TrEMBL
MKLTHLQEHLSLLERSKTDFSMIVVDIDHFKSVNDTYGHLVGDDVLSRLAQLMQQFSGER
AVVTRYGGEEFVLVLPLATAEEGIYFAKELNKLIAAENFAEVGHITISLGVSTTCENCSV
HQMFKKADDALYYAKKHGRNQAIHYNQLEI
>A0A336QQF1|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MKIVQDKLRNRQALLVSGLITLIFTSLFLLIIYEQRIAAVSDGVNRMQARMMDIFNDNEL
IADAIGERYHHIKTGEQCGDISQFVPRNEIEWGINADPKRLHSATGTIIAQQASHNALCM
YTAAEFIRDMVNELNPGSFDAHRYIIAKNSDYFYWFMASDSRNFSFSNSEMARDLTNFFY
PPVDFYTRLLQKNVKNKALSSTNFYTDKITGEKAYSVVSYIYDLSGKEISDQIVAYLVYD
HSKPELQEALAQAFDHQIPPALNVALVNLTDNESLCLSGRCTGQSRFLVRNFSEKYALHY
SLSLGRFMTRDTHAGIVILLAPFFFIIITFSLKSWLNESDLKVYIDTLTGCFNRRILDII
KRRDLSHCSVVLLDCNKFKAVNDTWGHAAGDRALQIIANRMLSNTRTSHDIVIRTGGDEF
MILLFRSQATDAIAIAQRISGQVTSHVFVVDGHTVPLSVSWGIAEVNGELDVAIQKADSA
MYKMKHTKEG
>A0A378ZV23|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MLIVFACLFLAGGLQLFRQWRIEREHSGILLWSVSLLVRVPGFALLALRESLTGLWVLHL
GHSLLCLGAGLGYAATRHFSGRHTSLLAMLTPIILWNGLCIIPGFLENATLRLTSLSFIL
MFVSAVTAFEFLRAVLLSKPVRMVFLMLFAGAALMHASRMLLMITAPETTQYFSSLGAHG
SVSQFLAAILLSSAAILASVMLFRDGQLQNLRREAEEDVLTGLLNRGAFRSAALAALVTA
RREGAPVCMILCDIDHFKTVNDRFGHAGGDTVLQAFSQLMRDRLGPHGLTGRIGGEEFAC
LLTGESALAAYGLAEGLRVHTRVLSMLGGNPGFRITVSTGIGIMPVSDADVDGLLQRADW
ALYAAKRRGRDCVEVDGQHGIDAAGGKGAAPSPAIVVAGTSDYAPGAQS
>A0A7W9A2M8|diguanylate cyclase|EC 2.7.7.65|Brevundimonas halotolerans|TrEMBL
MPARILVVDDIETNVRLLEAKLTMEYYDVLTCNSGQAALDLAAAHHPDIILLDVMMPDMD
GFETCRRLKANPATRHIPVVMVTALDGREERIKGLEAGADDFVTKPIDDVVLLARVRSLT
RLKSIMDELRSREESGRRLGVDTDAAGRLRATGGRILLIDDDPRQVERIRSQLDGEHRLT
VETDIEKGLAALRGPFDLVIANTASRGFDGLRLVAQSRSLESTRPLPVLAVVDPHARARM
IKALELGANDILATPIDVEELAARARTQVRRKRYADFLRQKLDYSLEMAVTDALTGLHNR
RYMAGQLQALVGRTNQGSEPVAVLMMDIDHFKAVNDGFGHDAGDEVLREFAVRLATKVRA
VDLPCRMGGEEFVVVMPGTRLEDAVRIADRIRADMAGAPFPVMGGDAHLQITISIGVAAT
TGREDTPDALLKRADEGVYEAKSAGRNRVIARAA
>A0A7G9HU46|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIMGENSHFVCRFGQWLNN
QSRYNEDDCSYVSKISATHEKMHLSGKKLLMAIVENRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDALTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
SDGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKLTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A7G2IU30|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPENDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSRAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKKC
RSGHS
>A0A388RPW2|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. P-10|TrEMBL
MWRRLLPQPRWLPRLAVMRPQRVVLVCFGAVFLITLVVAARELYLVRERVIGERQHALVL
RALGVDAILSAERRRLFFLRDFAEHLFALHANVGTADADIERAYAARNDEVWQLPLPRGD
APLTGVSPGSLAGLQGFARRDADLKADLMVGRTLSQLLGLGLRGDLIQGNALFISSNGFF
AIYPQQDPARAARLMQRFDSMDYYRGHMPAQNPTRAIHWAPLYTEFEGARVLTTISIPVY
AGSQFRGVIAVDVAQQRLHDLLGAASAPGTVQYMVNVHGDVVSSSGSGFSTLQKWPEAVP
GDWSGYRVADLFARGSGVLSHHGDLLFFQRAGQSPWLVVDVLPLSAIVPAMFSQLSGPLL
IVWLLLPLLLWVTMRVVTQLFDHYLALGEKLQELAQQDPLTGLANRRHFRASFGREARRQ
QRGGTALSLLMIDIDFFKKVNDRWGHASGDRVLGTLAQALHGTLRAFDLPARLGGEEFAV
LLPQTALGDAVRIAERLREAIAGCRVEAEPEAEPEADPALRAGDAGTAGPERVIRFTISI
GVAESPADAPLALDALLAIADRRLYDAKTHGRNRVVSDDGLHEGEAENTEPAT
>A0A8E2M195|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA464|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRAGFYVST
LPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDGKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRIDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A8F7QDH2|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MLNLLQAAVDQAFNAVLITSPGENGRGHKIIYCNPAFCKMTGYSLEELFGQSPGLLQGPL
TDKDLLKKLRITLLEDKPFLGSALNYRKDGTIYLVEWNISAVRDATGEIQAYVSVQQDIT
ARAEAEHRQALLARALDATEDAVLISDDKAQILFVNQAFEHQTGYSSSEVLGKTPKFLQS
GTHTPTFYADLHLALAQGESYQSTFTNKHKDGHLYYAAQTITPIKDENGSIAHFVSVSKD
VSDLVMRTHELKKQAEHDALTGLLNRRVGERKLKLCCKTAQSKKQAYALILIDIDNFKKI
NDQFGHDEGDRVLRQCAKLINLSVRVGDIVTRWGGEEFLIVLPGCPLDAARDLAERIRKA
VASQNDPIVGKITLSLGVGTVRLSENYTELLKRTDEALYQAKRSGRNKVVIAEPVL
>A0A011PB27|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MWRVASTCSQEAAIFLEGGQVLETIDRALLDVFVANIAACFRNVKLVERLLRAQQEIEAQ
RAFLRTVIDASPHFIFVIDREGRIRLANQSLAERFGQSPEQMVGRAQADFVSDPQLLQAL
RSDDEAIAACRQQRIEREISFIGRSGEERWFHTVKVPLKDASGAVDQVVGVSIDVTDRKR
AERRLLEAKERVQVTLDSIGDAVITTDAQGCIDYMNPVAESLTGWPSAEARGRPAGEVFR
VVHEETRVPAKDPIKRCLVEQRIVSLSGHCVLLARDGREYDINDSAAPIHLGDGGLQGVV
LVFHNVTETRQLARQLAHDATHDALTGLINRAEFERRLERAVSSAQDEGARHVLCYIDLD
QFKVVNDTAGHAAGDELLKQINALLAGTFRESDTLARIGGDEFALLQENCPLERGHIVAQ
AALRAIREHSFSWEGRTYQVGASIGLVPITAETHDTAELLTRADVACYTAKELGRNRVHV
YQSTDSETAQRHSELLGAAGLRDALERGLFRLHYQPIVALAGAEFRIVRYEALLRVVHEV
DPGRKGELVLPAAFIPAAERFGLMGAIDRWVIRRAFQEYAQGIGRTGAXPLPAGGAESGS
GHLPRGRAGSGDDRPCIARRLRRQHCRLLPQRQAGRTAAAGATGDRGAARLSPNRHRRQS
ALHLRHRPRGQDSPRQPEPGGALRAVARADGRTCAGGFRQRSAVAAGSAQR
>B7LTP2|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)|TrEMBL
MVHQTSVENRSWHKKLARRLGPGNIVNICFVVVLLCSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMHEALMTPLNFSALQNAITQFQQNRNKRYWQIGLDR
RRTLMINGVSDDFVSQSNLLSRADDDLHNELTAALEVGYLLRLSHAPGAAAQQAIYVSRA
GFFLSTQPTSNSKDILTRYFDFVTQPWFNEQSERMNKSRGVRWFSTPGDHTNETKPQITA
SIPLDNQGYWHGVLAMSIPLAAMRSLLVNATHNDTDGEYQLYDSKLNLLTTSTPEQRKIN
TFDDRERALLAQDIEHDTQGGIRMNSRFISWERLDHFDGVLVRVHTLQEGVHGDFGSISI
ALTLLWALFTTMLIISWIVIRKMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARFLA
QECRENQRPFSVIQVDLDHFKSINDRFGHQAGDRVLSHAAGLISRSLRAQDVAGRVGGEE
FCIVLPCANLAQAQEIAERIRLRLNEKEILIARSTTLRISASLGVSSTEETGDYDFEQLQ
SLADGRLYLAKQAGRNRVCASDQPLSEDKK
>A0A0Q0IW33|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MSNELLKTAALNLKKAVPLMLKHSIPTTPTNYALWYAYVSESNPKLNIALDATIAQNQQY
SPTSSELLYRQHIADPVELDVRSMRQNLDAMVCELSQSLKDTNHDTTTFQTKIQKEFSKL
AELENQGFSLEQVIKVVKNIVSESANIHSSTTSFTQQLDKAQSEINALKQRLAETEKDVL
YDALTEALNRRAFDDDISALVNQSPNGACLILIDIDHFKQFNDTYGHQLGDLVLKVVAKR
LQESCRDGVKLYRFGGEEFAVIIPNSQQRVARQLAEAMRRSIEKLSVKDRRSETRIDNIT
ASFGVSEWKHQQTSSQLIESADTLLYEAKRLGRNRVMPISN
>A0A1C9W6K1|diguanylate cyclase|EC 2.7.7.65|Microbulbifer aggregans|TrEMBL
MTEFDPESTEPLGALSELSAGSERIPHLLPGAAEVALAEVADGVIVTDAAGRVTYCNPLA
GELIGGALALKPGRFLDDGLKLADTEGKPLPPLLAGSGDREGGALADGREFIAAIPRTDD
LGEVLLEVSVQVQTVRAEGEVTGFVVVMREVSEERRLFSRISWQSSHDSLTHLPNRQYFE
SELQRALANCKDRRQHHVLLYLDIYQFKVVNDTLGYAAGDQLIRQLADQLRQSLSPEDVF
ARVGSDEFAVLLRDCTIEEARRVVVRLREAVQGFVFTWDGRESRVAISIGAVAVDRASPP
AGQLLASANDACCAAREQGRNRVKLFSDSRRVLEKRRQSTWVAEIHAALREERLLLYRQP
VVALQHEDRLHHYEVLVRMRGRDGDVISPGDFLPAAERYGLIEEVDRWVIRRIFDYMAVE
QRHGLTGHSYAINISGLSLGDEFFADFVLEALTEAGVPPSRVQFEITETSAINNLERALV
FIHKLRAAGCTFALDDFGRGASSLAYLRQLPVDFLKIDGSFVRNMLDDEIDSAIVSTVNH
LAKSMGISTIAEYAETPELIGQLRLLGVDFAQGFGIAAATDLPMLEGEGA
>A0A2K9JUQ0|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MPYADLLKPEASQQTLLKWQKTVDLMAKIFSAPAAFVVQKKEDGFAVMIASDQEENPYPA
GGFIPQETNIFCKHVVANNHNLYEQHASVNYQWDDNPEVANDGFESYLGVPIHWPNGKSF
GTLCVMDFKPTNYNASLVEFIEHLRDMLEDDLVMIERYSKIKAIAMQDPLTEVLNRRATE
ILGEHKRDIALKLGGALYCVFLDLDGFKPINDSYGHEVGDQVLQSLAEALKAASSEDDII
GRYGGDEFLAIVQRDNEEAVNDFIFQSEANFYQALKKKKLPKCGFSAGFAKSDSKFESMT
SLFSRADKHMYQKKMN
>A0A0Q0JIN4|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MMNMLTRFSLKQKAIAATIVLVLVLLSITLVSLVSFSSTQERLTKVTSQYQPKMLSAMQL
TSHFYHSLSVLGNYLIEKDDYNMNLYREKVNDINSTLTELVNLTNLNPELDDSEQLLRIR
QLVDKIITHNISMLELAQNNNKNMPAIGIASSKLEPIAINMNQIVNDLLLATAINEQQSI
LPLIEDLRYNWIMLVSEVRNYLAFRQLPTIDEIALFKTGVNQSFEALEIRRYEMDDDQLD
LLDEFEANTAAYQAALVQAINIHAGNNWRADRQLMKQNITPTLKELTKELEVLVTKQQRR
IHESNLALSKQISEAENTIRFSIQVALAIALLVIFLSFKNKRLLSDILIHKESERKLFHK
AHHDTLTKLANRAFFDDRLFKMFLDQETRSKRRSKRENNLEINSYFFGLLYIDLDGFKAV
NDNVGHDAGDFILIEVAKRMKNVVRNSDIVCRLGGDEFAVLLNDINHINSIEKISENLCK
TISQPYHYKEQVLNVSASIGFSYSRHPQLPLHKKVKFRMEAIIKQADTAMYHAKENGKNQ
YAQFK
>A0A5J6VXC7|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. E76|TrEMBL
MIKDINSMPRPTFKRTLRRISMISVVITMIIVWLLLSVSSMLTLKQYAQNNLRLLSVSIS
HTLEAAMVFRDGPAAYDTLAALGAQGQFASAQVVDNMGEIIADWSGTAENDRDVMGGLVS
KWVFPTPVVQQIYHNGSVLGEIRLTAMDNIITHFVWTSLGVLTACLILASCISLSITRYL
HKGMVNALNNITEVAHDVQTNRNFSRRVSAERIEEFHRFGQDFNTLLDEMETWQTQLQRK
NASLLISATHDPLTGLANRTAFRQAVETMMNDRSRKIDAALLFMDGDNFKQINDTWGHAA
GDRVLIEAAQRLRNFSGETHCAYRLGGDEFAILLTGVHSTDELLMCITDLRQALLPPILL
NNGETTVLSMSIGYALAKCTATPEALMEIADKNMYHDKSKRRLAFG
>A0A3W8MBM5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKECSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3L2LED3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRLGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLQLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A5Y7WBU1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A756ARM6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLSAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6L5BQW3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MENQRGKGLSFARRIYMPRTVGLGIGCICVTAALYPLNMPGWVWILMLLNGFVWPHFAYQ
LASRSPYPYQAERRNIIGDSLCGGFWAAAVQFNPIVTVTILSMMTMNNVAAGGPRLFLQG
ALAQIVGVGIAWLVFGPAFTPTATPIQVWACIPSLTIYPLAVGMVCYRLAFKLSEHKRAL
SALSRTDSLTGLLNHGAWKDLLHVKFQQCRQNHVASVIALIDIDHFKAINDTYGHIVGDT
VLRQMSFELRRNLSELDLAGRYGGDEFCVILPNLSLHQAWEVMERLREVLNEYRHPHVPE
LRIKLSIGLATYQTVFTDAIAWLNDADKALYTAKNTGRNKISVASGSSSGGSTKRMSA
>A0A174RE05|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MKKLSRHELMQYGTAIISFLIVMTFTLLIFFWFVQQSVDKSVQNVLQKNTLQQKDHLELV
LEKEYEFLESPAAYFGTTSDLFSNDNLQLLAELASSSSYHRLMLFSTDGIGHSSDGKKTD
ASSRDYFQKTLEGRRVISSPLSSSVDNETLVVLTVPVYDKDQNIIGVFGGSIDVTELTTM
LFEDLYSGSGYSFITDPDGNIISIESTHNEIQKNFFTSSSDWVFQTSEDGATLQEDFKQG
HANCRKIISDLSYARYISYQPLKYNGWMLCYIIPAVDARQPFAFINNFEIILFAFFICIV
LLLIFALWKINQKNQTSLLRQAHTNALTGLLNKVYAEHTISEWLREKDFEDLQALMMIDM
DYFKQINDTYGHATGDQVLKIFAGFLKEQFRATDIIGRVGGDEFMILMKNVRLDYSIHLH
LQKLYTNLQNIDIPELNDQKLSCSIGCAVAPTDAESFSQLYRLADHALYTAKHNGRGRFV
IYHDIKNQQETVLS
>A0A635AWA8|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTYYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U6SH27|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVALPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKGRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3J4NDI6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTILSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLHLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A5T7C9I2|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MDEAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVSQPVFGGWWLLLVGWSF
VWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAALFMMMSMNLMGAG
GRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIMLYPLLFAWVSYQTAIK
LAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLIIDIDHFKSINDT
WGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAITAMSRVHERLNT
LRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNRTEVAA
>A0A663B2M4|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MISRILETSVDREDKIYRWGGEEFLLFLPHSPIARALMVAEAIRQAISEYQTLSVTVSIG
VAEHHDGEAIDQLFYRVDKALYAAKNDGRNRVTRLPSENVAAHSGRSE
>A0A663BEW2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQRKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAVAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSQAFDPRTRPWFIKQAEASTFSHYTSPYMDFFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVSNELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNTTLVNLTRHETNLVIGGFALAAII
IILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRVNVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A380Q4S7|diguanylate cyclase|EC 2.7.7.65|Yersinia pseudotuberculosis|TrEMBL
MNTIKNQSMKPKKNHNSAEKLPTLAGVLRRIHLSVAIVSVVTAGIFLTVAALFALRVYVD
HNLHLIARAISYTTEAAVVFGDNVAANELLALIASNEEVAEAKIIDKHNRQIACWTLPDD
GPIHHMEQIVARWILPDPVVLPMFHAGDEIGKIVIVGHGGSLLRFLLQGLAGMLACLTVS
TLVALFLSRRMLLGIVGSLNRITEVAHNVSRHRSFGQRVPSAKVAELNELSNDFNGLLEE
LEVWQKHLTQENDSLAYRAAHDSLTGLANRAFFEGRLSRTLNDCQPGEHTAVLFLDGDHF
KDVNDNYGHAAGDLVLTTIAVRIRALLRETDLVARLGGDEFAVLLTPIHNLDDVLTIAEH
IIDSMALPIILAEGGEITVSLSIGIAVYPDHAQTPEKLLQRADEAMYQAKKNFRSGKRIF
AYQPKTTHTKILG
>A0A2S5CWZ3|diguanylate cyclase|EC 2.7.7.65|Lysinibacillus sphaericus|TrEMBL
MKKLRIKLLISLIAFALILVAVISYVNRQILVTNIETQEASNRTLIENHILADMQTVDNA
HFYFDKNISDQMEKELKALATYYKQNPKIDTWNLQQMKNQHGMDIYILDQTNTVIYTTFQ
KDLGLNFSLCCKSFSALLDERRESGQLYTDGIDISTTTGEYRKFSYLATPDKKYLLELGL
KLDEVPVFQTFNFGKTAAYLVEKYNDLLDVRTISAGGVFFSDTESARITVKNQTKKFQDH
FKAALQTMKPAEYQQILDDGYIETYRFLPYEAETVRGASTKRVVYVKYGNRTELNALANN
TKQFWYVLMIALVTALIMLVVINRLFSKTIHLATYDPLTNVYNRATYISKMDKLLKKRKV
NTPGLLLIDLDNFKQVNDRFGHAEGDRILIETAKILKDVVRTEGFVVRFGGDEFAIVLYD
TNNEHMVQVANAILEKIRRLKNVENHKWSVISVSMGGVICEKPNETELSLFERADKALYQ
SKKAGKDQYSSYHEVASTEEKYNS
>A0A378YIS7|diguanylate cyclase|EC 2.7.7.65|Pandoraea pnomenusa|TrEMBL
MPDAMPAVPPQAPSRAATELAQTSPSNLAQGATGVTNDDALMFDLAPVSLWLEDFSGVKQ
MFDTWRAQGVTDLRAHFKSDPGHVSACSQRIRVVKVNRRTLSMFNAPSLDTLVANLPRVF
RDDMLKTHIEELCQLWDGRTQFTSKTVNYTLDGRRLDVLLNGSVLPGHEATLARVLISLE
DVTELEHARERVTMGEQYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVH
PEFVERCMTEIHVLDVNRHTLAMFVAPDKATLLARLPDVFRDDMRHNFREQLIDLWENKL
FQQREVINYALDGNEINVHLQFAVLPGHEARWDLVLVALTDITARKKAESYLEFLGKHDV
LTKLRNRSFYVDELNRLERKGPYPVTVVVADLNGLKAVNDQLGHAAGDGLLRRAGEVLGK
AVVAPQIAARIGGDEFALLLPSTDATGGAAVMESIRQLVELNNSFYPGTPLSFSMGMATC
EAGERLEATVQRADLLMYEEKRNHYAGSVNERRVLDALPSGSGSATTPTTPATPGSAGTP
GSAGRGDA
>A0A6S6Z5Y1|diguanylate cyclase|EC 2.7.7.65|Achromobacter animicus|TrEMBL
MLDPILAELSTTLPAAKSVEQLTRPLLDMLGAVTGLESTYLTAIDLKADLQHVRYARNVG
QLQIPEGLSVPWDDTLCKRALDEGRMCTSDVSQCWPDSDAARQLGIQTYVSAPVRADDGA
LYGTLCAASARRHNISPQAEAVLKLFSSVIASFIEREMLVEQLHSANVRLMSYALTDTLT
GLPNRRAVYEALDRLLARAVRENGSVLVGVIDLDGFKSINDTYGHQAGDLFLQEVSRRMA
AALRGSDMLGRVGGDEFLLIGPGPALTGKRADEGGVSQQAEPDEAARAMEERILAASMGR
YRLGEATVAYEGASAGVVALDPAGLDAEAAVRLADTRMYEIKHARRAARVIH
>H1WCY3|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MKISIPQPRRYAIASLPLGVSLVEPLHQLIVNHQEWMVMQLLQCFGQTTQPSIITHLRSV
QGLTSRISLLLIEMTADLTPGYLVSDMEEHLQTLGGISAIAISAETQTDISAAEMVETLQ
QYRQCYLNLIKLGEFSSEQEHLFSQVVGDLFTAIERQFFAQEKQRQYQTIIDQYLDEHID
DSINHIKASPMEMIFNAINLPIFIVNQEHKIIFANRKAHETLVVNSQIPREIYTWLRERS
PQIADTNISEIVAEIPITKDNITEWFCLRLYPIDSQDGSDFRAIAICEDITDSKLKAQRQ
QLQQQHLAQVQALTKTGSWCLNMNTGEMIVSEQLYHILGLTPQPTSINFEQLLNQIHVED
LYGWVQNYTTSLFMKQNYSLNYRIIQPDSSMHWVSQESTPVSDRHGQVTHIISTIKAIEN
QEIINSSITAEAALRESEARLRTIISTSTNGLVVVNREGRALFINPAAEALFGRPASQLE
GELIGIPLVTKESTELEILRQDGQLKIVRMRVVEISWEQETAYLASLTDITDFKKTEDQL
KMFSRACDQSPVSIVITDSEGDIQYVNPKFEEITGYKAGEVIGQNPRILKSGYTTEPEYD
VLWRQITSGKQWSGEFHNKKKNGELFWEHASICPMRDEEGYITHFIAVKEDITQQKHNEE
ILAHQANYDALTDLPNRTLIFDRLRQAITEAQVHHSNVAVMFIDLDHFKNINDTLGHELG
DFLLKEAGMRLRGCIRKTDTVGRLGGDEFLLIIPKLDDLVQAEYIANQVLDVLGEPFNLC
GEEAFISASIGIASYPQDGKNVSTLVRNADTAMYAAKQEGRNVFAFFTQNMNDEAQSRII
IENQLRHAISRNELSVVYQPFIHLNTSQIVGAEALMRWYNPELGNIRPDQFIAIAEESRL
IVDLGEWILSQACQEVANWHQQGNNGLWVAVNMSPRQLRTPNLVNVIIEAIANNGLSSDC
LELEITERSLVAEVPGVQSLIKQLNHLKIRLAIDDFGTGYSSLSYLKRFPFSVLKIDKSF
ISDLPDDQDAIALVKTMITMAHGLGLVVVAEGIETTAQLDFLCNQGCDYGQGYLFSKPLP
PAQFRAYLQRNS
>A0A650MHC7|diguanylate cyclase|EC 2.7.7.65|Clostridium neonatale|TrEMBL
MNYTILKNIRKFNKIILIFGILFICFSIQTKSIKAEENNVIRVGCPIVEGFTKIKDGVYS
GYAYEYLREIAKYTGWEYEFVEMSLNDAMNELKNGNIDIVAGMLKNDQSIKIYDFPEYDS
GYTYTTLSILKDNENISQSNFETLNGLKVGYFETSKVRLNNFIKFCENNSITNIDLIPYP
FQTGKELSEALESKEVDAIIDGDLLTNKNEKVVVKFGAIPYYFATTKGNTKITQQLNHVL
FKIKESDPAFNQKLYNKYFQINKEHFFILTEEEQSYINNMAPLKAIYIDNYNPLQYYDIN
TKKPAGIFIDVMNLITQKSGLRFELVRVKSYEEAYELIKAKKADLIIGAPSIYPIADENE
FTLTKSYLKFDMVEVVRKNKNNQQNNPKIIALPIGGAYYNINNDYEINLYDTFEECLTAV
EKGIADLTCGNNHSVSNYLAAGYYPNLTVISNDFKTEVSIGLAKPTNNNLLSIINKAIYS
LSEEEIKDIIYLNTINIKHSVTLKQFFFDNLALCIAVIILFLSLISIITYLLVRIKFKNL
VLSKELLLKKSQTDPLTGLYNRDAFEQSVINYLNTKNPILYGAFIIIDIDYFKQINDSLG
HKVGDDLLKDFSQLLKEFFSLEDILCRWGGDEFIVFMKDIEENNLQIVNQKLHQLCQLMN
KDISYNGCSKKISLSIGSTVIKQNLDFNEIYQQADTLLYEVKRNGRNGFKVNINS
>A0A290HWP5|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MQQFKEALSTFHALCLGMILLALCILKFGLIPSYAYYFVWQSTFVFLVIALFLSIYFNKS
KLFVLLLFPLFFDLALAFPSTLFTKLSVTAFWHITPLITALGYLLLYALQERGLFSSFGA
FRTALGLIVLGIGYLGLKYFSPSMQQALDTPILHASLHGLSKANDFILIISLISLLFIFL
ISLLFEVQSQKAPFWMLLAQMIPFLFLQESNSFLLFSLVTSLIAISALVHDAYRMAYADT
LTGIPSRRALEERFLHLGSHYMIAMADIDFFKKFNDKFGHDIGDDVLKLVAKELSHIKNG
GKAYRYGGEEFTILFNGKKKEECIMALEEVRERIFRRGFVIRDKNRPEKVPQEIQKANTV
KKERLSISIGLATSSKGKAPNEIIKIADDALYKAKESGRNCLICL
>H1WLM6|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MGIPLDTEVNSNAEALLQAADTAMYKAKRRGKGCHQIFNREMTAATLKRLTLETDLQRAI
AQQELITYYQPIVRLATEKVVGFEALVRWQHPQRGLVSPGEFIPCMEETGLVVQVGLLVL
QQACEQLNKWHQQGYPFFA
>A0A377FR69|diguanylate cyclase|EC 2.7.7.65|Exiguobacterium aurantiacum|TrEMBL
MIELWSGIAIGISLSFIAYKIRGRSKHSDETLGRFTDQMKDVIYIFDVKPVFRFRYISPS
LDDYLGEGTVAQNYEDPYDCFRRIHPDDYELLVNKVTGHVNYDEPILQRWQTNDGRYLWF
EEYTTPIYEGAELVAVQGIIRNVEAAVAEREALVYESRHDSLTGVWNRRAFDETIDRWKD
KSIAIGVIIVDLNDLKRVNDEHGHSAGDQLLQRTAHVLTSRSLKVYRLGGDEFVVLMSEV
AQSLFDQLSLDIRDAFDEAKISAALGSAWHEQVSDFKALYDEADRNMYVHKHRLKQETSL
VH
>A0A084XYA0|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-01|TrEMBL
MCSSPPLPPFVDLRADDAEIGNYATLLDSLDIALLVFSSDGFLHLRNTQAATLLGDTPVV
WEDENGQPLAVDHRPEMEVAQTRQAVRHRAIGIRKTASGATTWCRASAFPVFADDGSLRR
VLLALANLTRYRQLASQSMPTHDPLTGVFNQGYIRLLLDDEDRRARRYGTPFSLALMTID
DFADFCAANGREAGERLLAEVGSLLGRSLREFDMVGRFASDQFLLILPNVRINDAMIGLE
RVLAAVEATYAHHTKPPLTISGGVTEYSGEDSSILIEHLQPLLSAAQEAGGNRLCVDLEI
F
>A0A0F0CBX4|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MQKGKKKNKSSKWGISFAPITRYSIIFCILVLVIILLGGGVLSVSRMKTDANASLTASHA
RISQRVEGAVNLLESLASLPEFYDPEVPPIDKVKKLDQMNPYFGYMMICYVDSDIIVYSD
GSEPASLASRDYMQRLFSTGQRQVTDSFAAGADGTTLNYTVAVPLIDSQGKITGCLFCAI
YFDEVVEILGQSAGINGLEATLIGSRGQIMSSTEGLPYGDSVLDILNKRVLFGTTADQLE
ENLLAALPGSFWSMRNGNLFYTTYQRVEDTGWDILCSVNFQTAFNELLPALSLVFGLTLL
SCAGLLWLVRRYISSQMQVVDTLVHSVEELEKRIYQDERPEDVDFKEVLRLTSNGLSDSL
TGVVTRSVFLNQASALLKKADPKKTKALCFVDMDNLKYINDSCGHAGGDIGLKSVGYTLR
EYEKKYDGVVGRYGGDEFVLLLTSLDDEKELLSILDELVLRLQTSIRSGGQSIPVQCSIG
VSIYRSGTELKQMIADADEALYYVKQNGKGYYHIHQN
>A0A8G0G4F7|diguanylate cyclase|EC 2.7.7.65|Devosia salina|TrEMBL
MQVSGSTHFTARFLLPIAAAAGITMLALAGFLVWSARSIDADAMSRDRLLLERALEELQE
KLLLAQEELATWDEAVTAFHERDADWLVENMGVAAFDTFGHSRTLILDRDRNVVIAMRDG
GRVRAKAAGGAEPDLAPFLDRIDSLEAEAQISAYNAGVADTPPQAMDFAHFEGQPALIGA
MPILSYSGENAPDVGTEAIYVSVILLDAALAAELGDQYRIGVPAFLTAAPDSSADAALSI
TDAAGTPIAWLTWQADLPGTRLLQAASPALVSAMVIGLLIVGLLLRSLHRALFALQAERE
EASHRAQHDPLTGLGNRTLFRQRLGESFRAMPAGEPRLAVLALDLDRFKQVNDTMGHQAG
DELLTAVAGRLNALVRPQDTLIRFGGDEFAIIQPGITSHEQPQALAQSIIEALSRPVALA
AGLAHIGVSIGIATAPDLAHGETELLRFADDALYRAKHGGRNRYCLYSPSLPPEPARRQA
QLREALSAQRSSA
>A0A0N0GPX8|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MSFAPTRLRHFQVLLLAYVLSGWLGFALGALHHDADLIALWLPGGIALIMLLMLGWWGVP
AILIGSLAVHVPLIVGHLHARQGALYLGTLALIDLLQAWLAMRAWRGREARLHAPLIRRT
HDLIWFWVQVCLLPVAVTTPLIAALQSTMHLLPDQDPDTLVRQVLTLALAGFGGLLLVAP
CYVVWRDRSRWPWRSLPWRTWWPSTLICVVVLAAFWFYPPGLTLVLPLLLAKTIHYRWPG
MAVSVLLVGLACWVGTVLGFGPFVDTSAHLAFVNLQLFLFSTAVMLQYLALAHEMLLRQH
WQMEAEVKQRTEALASANARLEELATTDELTGVPNRREWQRRCAHAVMLARRHQQPMAVL
LLDLDHFKQVNDTYGHLIGDLTLRTVSRACQESLRGSDSFGRWGGEEFVALLPDTPLEDA
QQVAEKLRHAVSAAQIKLDNAPVPSMAVTVSIGVARLHASDADLDTLLTRADHALYFAKQ
TGRNRVVLETELPADGPRL
>A0A379XNV1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>V6F688|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MNLRAARRSEDGPALPPWPILVVDDDPQVHSMTEVLLRDFQFKDRGFRAVSAYSAAEART
ILECRDDIPVMLLDVVMETDHAGLSLARVIRQDLGNQRLRIILRTGQPGEAPEREVMLAY
DINDYRSKTELTAQKLFTALVGALRSWIDLDTIERLNATLEARVLERTRELAEAQAFSGR
LVELLPNPLWVKDLAGHYRLYNQAFREFFGIDAEAWVGHSAEEVLGRHLPPEELDSDCRV
LDGSSRREEFETTIPDHAGRPRALLVTKAALPADGVVPNGIIGIAADITERKSLERELRR
LATMDSLTGAPNRRHFSTLAHQEMERANRYDLPLSVIMLDVDHFKKVNDSWGHAIGDEML
KAVTTAIQGELREVDVLGRMGGEEFALLLPQTGIDGAAQVAERLRSAVAAIRLPLAEGWL
HATISLGVTTRLEGEAQFEHLLGRADRAMYEAKQAGRNRVAIEPGR
>A0A1Y6KZ57|diguanylate cyclase|EC 2.7.7.65|Photobacterium aquimaris|TrEMBL
MTGVNQWLRLIILFLVCFTIAAYGWFLLGGAKKEYIVTPQNSQYKIIDDSVQSGATTATL
DISKHSVFLECDIINKAKWPFCEIAISLTNYIDKGIDLSTYHSVGIDIDYTSPLEDERVR
VYLRNFDSTYANVNDPISLKFNAIEYSPGVDEGLKIFPLRNFQVLSWWIAENNIPVDKSS
RQFDNISVIEIATGSYVKESYYAIRLNRLVFYGEWISESSLVKALLLLWVVTAIIIIMSE
RFILDKRIKHTEERSQRLRDANRLLYNKSLKFEHLACTDPLTRIRNRHTVTEWLEEITIQ
TKSNDIPFSMIFIDIDHFKAVNDTYGHGFGDTVLVKFAETIDKLIRRSDMFARWGGEEFV
LFCPETNMSTAVEIAEEIRETIANKVWDFDREFKLTCSLGVAELVNESSDEFIQRADLAL
LKAKKMGRNRIEISWEHQQLR
>A0A3A5K041|diguanylate cyclase|EC 2.7.7.65|Buttiauxella izardii|TrEMBL
MAVSGSVSVFGNAIQRVISRFKNPQKVVNLCFIVVFLFSTVLTWREAVVLEGAYVSSQRN
SLDNVATLLDRQLQHNIDNLLFYRNSMLYALQSPISTDKTRKTLADFDALRTQPYWQLRL
DLNRSLPMNGVSDEFVNNSPLLDRDEQTIHTELSSALELSYIMRLSHQTQTLPRRMFYAS
RSGFFLTSTPPPNDPQIVALYYRLVAQPYFSSQSPANNPDRALKWTHTFNPESTTGQIIT
AAIPLDYNGRWYGVLALDYPIDSLHTFLQQAHNEDHEGTVLLYDNELNPIATSAQSLPLH
PMFTAPQLAQIASAVTAAKAGDEGELRMDSRFITWAKLNNYDGLLIKVHTLEEGVQGEFG
RISIVLSVLWMLSTLMLFASWVVIRRLVNNMFSLQQTLTWRANYDTLTRLYNRGAFFELA
RKLSQECKQQAQPFSVIQMDLDLFKSINDKYGHSSGDKVLAHAAAMLSDAFRQGDVAGRV
GGEEFCIVLPDTSLEEATKVAERIRVRINSKELLLKQGTTVRISASFGVSSAFEFDDYDF
ERLQSHADHRLYKAKQEGRNRVCHTD
>A0A1S1HAH9|diguanylate cyclase|EC 2.7.7.65|Sphingomonas haloaromaticamans|TrEMBL
MGMLGHQSGRRGIRGLAGAVIAIFLLCGFAPFAHGAVDSLKIGAPLCYVVTPEDPGAEMP
SPADYRCHGRPRGYQAGTLWLHMPVQARSAGDDLALLVHLTRFDRLTIFSTYADGAVRTF
GVARGDFGTHWRDGGQIVFRLPDRDVPVASLTMRFDRLASHDLLRARLMPGSEADREGTL
VGPLIGGALTLLLLGTIYNLSLAHGVRRQFIAWHGAWAACVFIWGLIWSQLALLVVPGIA
GTLSSQICTFLSTLAIACATASAVTSLERSLLPRALRIGVLLLGAAVALVGLPAAFAVGP
AIEPIGQILGVLIIADLLAVTAAIVTAWRRGSVEARDFALAWAVPMATLGATQLLDLNDR
LLGGGAQIAVLMASAFQTIWLSFAITRRLARLRIERDAAQAAQAELDELARRDSLTGLLN
RRGFIAAAGEALALAERENIAFGLLLIDVDRFKAVNDHFGHDVGDRVLRRIADRLRQWEG
DICTAGRLGGEEFVLIVRGLAGRPLAEFADRVRIGIAGQGYDGLLPADMPVTVSIGLADT
GAATSFPLLYRLADEALYEAKRGGRNRVVIHASGRTALPPRPARRA
>A0A1S1H995|diguanylate cyclase|EC 2.7.7.65|Sphingomonas haloaromaticamans|TrEMBL
MPDMPERSEARRTWDRIGDLLFTHGLEPTVANFDLCRRYVMGDTALVKTFDQAIERHGGL
TRTALAGLMAVHSRTVTSDEIMRFAQQARQKAEEAAHVIGETQGDTRRFADVLEAGAVTL
ATGEGPEAVIAELLAETRLMTERAWAAEDRIRKASDEIQELRTRLAEASVSANSDPLTGL
PNRRALEARLRDAFEAARAQRRTFSLAICDIDNFKRINDTHGHPIGDQVIRLIASALSRV
GSDSLFVARYGGEEFVVVFDGAEPRDAMAQLDTIRADVAARQVTLRQTGETLGRVTFSAG
IAGMRGRRDTSAMLKAADDALYRAKSDGRNRIYAAD
>A0A330LA34|diguanylate cyclase|EC 2.7.7.65|Nitrospira lenta|TrEMBL
MRGRSPLVWLSLGLVSVTVSLVLLSNALFHVAPDEAQQMYQYRKALAESLAGQFSRLAQD
GNLAAITEAMRVLAERDATIQSVALRQGMREFVAQVGDHRRYWLLPPGDGSTLDQIRVPI
LKGPDRWGTLELAFRPAVVGGVGGWLRSAWVQFLGALAGLGFVGYWIFMRRTLRQLDPSA
VVPQRVRAALDVLTEGIVLIDPSDVIVLANRSFAARVGLDAQSLLGRDLCGLAWIATRHA
PLPERFPWTASIADRQIRVSVALGFRASDQTERLLLCNCSPIRDDRGMVRGALASFSDVT
ELEQANEQLLEALKDLNVSKQDVLRKNEELHWLATRDPLTGCFNRRAFFEQVETLVARSV
ERRATLGVVMVDIDHFKLFNDRHGHAVGDQVLTAVAKTIQSVLRQEDVLGRYGGEEFCVV
LNDVTAALLNEIAERIRRRIENESGASVRSIKGLSVTASLGVTLSLVESAPDIQTLLGEA
DQALYEAKGSGRNRVCVFRSKDVSSAAA
>A0A5P9B456|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MEKDFLLEAHRSVNSLLRRLALGLDRKELNEKIIQLTEHLFGERMASILMLNPDTQTLHL
EHAPNLPQFYNEKIEGVSIGEGIGSCGEAAARKKAVIVSDINQHPNWAAFLPLTQQANLH
ACWSVPILSSNDHVLGTFAIYSQCPSEPHEFEVEILELLASLYSVALEKYELEDQLQYYA
TRDSLTRCLNRRALLFEAQKVLEKRCFGEKIMGCMFVDVDKFKSINDTYGHRFGDEILER
VAKVLDDATTACAKVGRYGGDEFVVFSCFNSEESFSQTYRVLNSTLQEALYIDGTQFSVS
VGMAFEKNPNGLSGLIAQADKNMYQIKQSKVH
>A0A5P9B719|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MNRASESEVVIRRLYQITNHYQKGFDVQIVQLLEMGLQRFELDIGILSKVEGDNYTVQYC
VTPEDVPLQQGDSFDYRATYCEITCQARGPISIEHCGTHDVYAAHPAYKAFALESYIGIP
IYVDNEIYGTLNFSSPTPYYRKFREIDIDVMKLMASWIEVELVRRAQELRLKQLNEKLEY
QALYDPLTRLPNRRCLFKKLNAEVEKLRAGEGVGSIAVIDIDHFKKVNDNYGHQIGDDVL
KKIANVLRENTDEGGIAARFGGEEFIVCYPQSTPEYAERRITQLLQSVKTITLDREPITI
SAGVCHFKLADEGDQLNRMSTLDNLIKVADECLYLAKENGRDQFVARPYIMTSQKVCTS
>A0A7W6CI74|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sediminicola|TrEMBL
MSDALLGQISETVASAQTVEQLTRPLLTMLELVTGLESTYLTRIDETAGVQSILYARNSK
VMQIPEGLSVPWGDTLCKRALDAGQPFTDDVAGCWGDSDAARALGICTYASTPVRMEDGS
LFGTLCAASSEKRPITQEGRQVLLLFGTLIQQHIQRENLLEKLQRANRELEGFSFTDTLT
GLPNRRFIFQELGRLFSLAQREGRRVTVAFIDLDGFKQINDTYGHETGDAFLIEVGRRLA
AGMRGSDLLGRLGGDEFVLAGLGPAQGQDSELTVAAMRRRLAALVEGHYDLPCCAMDYPG
ASLGIISADPRQTTVDQALQDADAAMYLEKRQRREARAQPA
>A0A3G8JR97|diguanylate cyclase|EC 2.7.7.65|Gordonia insulae|TrEMBL
MREGNRGLWGKPAQTTISDDTRHVLDHVRVSEPIQRYGIAALTLVFGAIGLLSTLTPDGS
AGSPVRQVAVIALSATTVPVAYLVTRVPLGSVWWSKEASIKGINTAFVVYADLGFAAALA
TYQDPTIALFMTALFAVISGYVAHYVKRPALIFHVVVTTVVIACFGFLVWLDGTPITTVV
LMVTVSAVASLGLLAFLWMYTIGSQHTLQTQLTSASTDSLTGLLNRRGFRYRASALIRRT
GGPFVLVVIDIDHYKRINDLYGHTVGDVVLQRVADLLRQCAGDGAVIGRLGGDEFAVATI
ATHTEAIDLLETIRRRSEGLLSGQPVTMSMGVVAHTASDRPPGWSSSAIVDDAMIAADRA
LFRAKAAGRDTYSVIEAPPHDRTPFDQPASEVPLTG
>A0A432WGI7|diguanylate cyclase|EC 2.7.7.65|Aliidiomarina soli|TrEMBL
MKTFCAQRQANQWQALLEHYDQQTRSYANQVACQYKSELASHFYQQMLSDNDSSQYLTHD
DVRTRLHGSMQKWIENLFSTAETPTSVIEAVDVQHHVGEVHARIGIPVHLVMRGARALKN
QLGERLNEPSARHYVAELIDVAIEIMSHAYCHSHERNARAEEAYRLFSVAENVASEKQRQ
RAALLDWENQFMFEKAMGVSQAQLPRIQGSEFGLWFRHKGAHAFEGMRETIMIQQAMKHI
DTEIVPVLGDLATAAQDPMALLRELRENCKSIAFHIEYLFDQNDALEAGRDALTRLLNRK
FLPVVMSKQVATAQKSKESFAVLTVDIDHFKPVNDRYGHEAGDMILQQVAALLMNHSRAG
DYVFRMGGEEFLIVLVDVNHEQAMKKSKELCALVAAEPFRIARDEEVSVSVSIGVSVFDG
HPDYQKLLRASDDALYQAKNQGRNQVVLAAS
>A0A5E4WKC9|diguanylate cyclase|EC 2.7.7.65|Pandoraea communis|TrEMBL
MPDAMPAVPSQPTASPYAASGASDDTLMFDLAPVSLWLEDFSGVKQLFDEWRAQGVTDLR
AHFKTDPAHISACSRRIRVIKVNRRTLTMFNASSLDTLVANLPRVFRDDMLKTHVEELCQ
LWDGRTHFTSKTVNYTLDGRRLDVLLNGSVLPGHEGTFERVLISLEDVTELEHARQRVTM
GEEYARGLFEYSPVSLWVEDFSAIKLLLDDARSRGITDFRTFTDVHPEFVERCMNEIHVL
DVNRHTLAMFVAPDKATLLARLSDVFRDDMRHNFREQLIDLWDNKLFQQREVINYALDGN
EINVHLQFAVLPGHESRWDLVLVALTDITARKKAESYLEFLGKHDVLTKLRNRSFYVDEL
NRLERKGPYPVTVIVADLNGLKLVNDQLGHAAGDGLLRRAGEVLSKAIAAPQIAARIGGD
EFALLLPSTDTSGGAAMIEGIRQLVELNNSFYPGTPLSFSMGVATCEAGERLETTIQRAD
LLMYEEKRSHYAGSVNERRATGGTGGSGA
>A0A1V2ETE7|diguanylate cyclase|EC 2.7.7.65|Sphingomonas jeddahensis|TrEMBL
MVLLGGGYFILSAATIWLTRFDGGVAFLWIATALLTARLTTLPVRRWPIPIAACLVASVL
TTSIWGFGPSLAGPLAIINVMEAAIGAWLLHRFARQQAVLDSHGWLIVFVAGTGIVAPLI
SAVLGGGLAAAIMSQPFLRSALQWYSGHALGTLAFMPIFMLVLRGDAARLITRMDRAKLI
ELLALVILVALVSFITFVQDHLPLLFLPMLPIVLATFRGGPLSTAASIVILALIGGALTL
DGHGPIGLLNAPIGAKMQFLQLYIACTMLTILPANAELQQRADLFSRLRESEARYRVLTE
NTTDIVVNIDLEGRLRFVSASIRQLSGREPEALIGKPMSALLHDRDIARATASFHQTIAE
PDTVTIVEFRGPQINGEARWFETHSRAVVDHEGNVTGVVSAIRDITLRKAHEERLTRAAL
TDPLTGLINRRGLDEELAKRLTAGGAGCVALFDLDHFKHVNDTYGHAAGDEVLRRFAALA
RSSVRDQDVVARLGGEEFAVVLPEATIDQARLVCDRVRRAVGEARVRIDDRTISVTVSGG
VASYRNYQPAGDVLRAADRALYRAKNAGRDQLALAA
>A0A840AHV7|diguanylate cyclase|EC 2.7.7.65|Roseococcus suduntuyensis|TrEMBL
MTARILAVDDIATNLRLLEAKLQAEYYEVLLASSGQEALQVAFTQLPDVILLDVMMPGMD
GYEVCRALKADIRTQHIPVVMVTALTDSTERVRGLEAGADDFLSKPVDNATLFARLRALL
RVKQVQDAWRLRSDTARELGIDNPAPPAISVQGARALILNSDAEEARAVREALLADDMIV
YTVTSVDEAFQRLSKGDVDLALLALPVDPGEVLRLASRLRAQNATRDLPLILLADSHQKN
EVLRGFDLGANDHCFRPMDPNELRARARNQVRRKRYQERLRADLDRSLEMAVTDQLTGLR
NRRYVRRHLDSLLRTEAAAVLILDIDKFKAINDTYGHNVGDAALREVAERLREQLRAVDV
VARYGGEEFLAVLVGAQAQAAMLVAERLREAVAILPVQSEGHVVPITISIGVAVGEPGMP
ADRLIGAADSALYRAKRDGRNRAYLAGEEDATAAS
>A0A0T9TIE0|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNSGAERNTGYAAEEIIGQSFELF
YTPEDLAGKLPSKGLQHANQFGHYETQGWRVRKNGKRFWGNLTLNALHDADNNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTQEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDNG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYVSNEIIAQHFGCFFLPEDIAAGLPEKLLKTAASAGRMEREGWLVRKDMTRFWAVTII
TVVHDNSGKLLGYAKIIRDMSERKQREDALRASEVARYEEREQLHRVLSSIQEGIISLDC
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNRLDAFNQCLNEGRHTLLPE
GSQLLSSQGERQEIRCSASPIHDRDNQLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLADSLSELSDNEQHILCYVDLDFFKDVNDTAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCKDKPATDILEQVVTDISAIQFHWHGQSYTFTASLGAVIL
NRQSETAAQAMRQADIACYAAKHAGRNRLSFAL
>A0A653J993|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MRAVAHVINGLLPCCRTIAVACVLICSSLASVEVAHAGCMDAPTKELRQLAELAGQDPGA
VLARTARDAPASLGTMRYSWRQAARAEAYDTLSRPADARRTALRLLKGELSSNNPLRVEL
LTRFAINGFNKDEIDSAVALVERARQGALRGSAADACLQIALGEMQRMRGAPERAVVYLA
EAYRATSDRRLSRQHVIATEKLARVVDWAGDHLQAISLIGEVIDWDQARKRMVALSTDFY
FRGVFNLGRGAFQAALTDFNRSRALAPAGVDPVGSAFLDLQTCSALIELRALNRARAACQ
RAEVVFGRYGELAQAQARLLLARISNLTGEHKKALDLLNGLLAKADALSASSSAPEAFRL
RSDVNQQLGRTAAAYRDLNIYVRGIERQRASEQMKQNAVLRARLDADRAVARNEELRQKL
DLSATRERERAKRESILAGAAFIGLLLVLIILGMSFYHRRKLTRIANTDPLTGLLNRRFV
SEHESLLVSTHTKTGDSLALAIVDIDHFKAINDTYGHDGGDQVLVAFADVARGALRKDDV
IARWGGEEFLVIFPRASEAEAVGALFRVKDALAAGVSTAGGVVPVKFSVGIVCCRTAERL
HTLVQRADEALYRAKAGGRDRIEIAELCSRPVTAKDTLLLADDRRIGAAA
>A0A0T9T7P4|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYNAEEVIGHSFELF
YTPEDLAGELPQKGLIHANQFGHYETQGWRVRKNGKRFWGNLTLSALHDSEQNLQGFVHV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
IGYPSNEIIGQHFGCFFLPEDIAAGLPEKLLKTAASTSRVEREGWLVRKDMTRYWAVTVI
TVIHDHSGKLLGYAKIIRDMSERKQREDALSASEVARYEEREQLHRVLSSIQEGIISLDS
EGRVELMNPKAEEMTGRSQNECCGLPIEEVFVLWSPLQDKNQLLAIQQCLSEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAISQLGHDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDLVARLGGDEFAIVLFNCQNKSATEVLETVVADIASIQFHWHGQSYSFTASLGAVSL
TPQTENAAQAMRQADIACYAAKHAGRNRLSLAL
>A0A376FG58|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MDYFTGHPTVTLYKPLISPEGRLKGTIAFHLDLTSMGFTLRQMVAPVQGEFFVVERDGAV
VLHPDTGALFKQYVSEALMDKMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSGETLT
DITRHETTIVGWGFALAAIIIILFGLYLRHASRTVLMHIINAIKTGDVSEAPRLEAMLSH
TIQSNKEREMAYVRQATHDALTGCKNRRAFDSDIAELLNAQQPFAMALVDIDNFKSINDT
LGHLTGDIVLRNVAREGIQIMQPHHVSLYRYGGEEFAVIFQAEQMTSALSLLEAWRTAVE
KRVWREENLRVTFSGGLGEWHF
>A0A4P7P3F2|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MPHFAQFFNQRLFSLSAVFILIALPIIYFLYQWQIETARNQEFQFYKANLTEKVDVMIQE
KQSTTHALAVAMTSPPNFKKALLENDKSIQKELENYSQRLKTLTKYKGVWIQLIDANGIS
IARSWTKKHGDDLSKVRQDVAALIQDPRRMNNFSVGKFALTFKSMVPLFDDNNQFIGMVD
VISQVNSIDHALAETNGVHSVVLVSKRYRKQLTNAFTGKFIDDYYVANSDADTRDMALIK
KFGVDKVFSSSNYVLFEDQLMVTRPIYDIHGQPMATWVTLKSLEDFAFVNVQKTQRQFIV
ITVFIFALLLMLLAMMYFKRQAEFEKRFFFDVFNTSTEIVYVSNQRRILFANKRFFEFFN
EFETLDEFHEKHHCICELFMPEEGFLKRHMNGVYWFNHVIQNKNESHYAKVQVNGKEYIF
LVKATEISNTYGDQYVSVLMTDITEEERYKSQLEHLIIHDELTGIYNRHYFNRTLEQEIK
RHQRYQSPFSMAFIDIDHFKKINDTYGHDVGDVVLLSLAKSISPLLRSTDVFCRVGGEEF
VIMMPETNLENALIISERIRTSVEEISSKEVPEKLTISMGLVELHSWDNVQSFYKRADEA
LYKAKENGRNRIETQVEERT
>A0A517LXK0|diguanylate cyclase|EC 2.7.7.65|Rosistilla ulvae|TrEMBL
MAMWTATVLLTLRMTGLLDDGSSQQIQARTQLCEVIAVSCSQFASRDDQAAIEVALRALT
ARNDDVLSAACRKADGSLAFASQGHQANWSRRDGEASSSTCIQVPVMQGDRAWGQIEVCF
QSPTATGLLGFLALPSVKLTVLTTLGCLVGFQLLLRRCFNQLDPNQAVPERVRSALDTMA
EGVVVLDEKYRINLANQQFADMIGCTVDECQGKNIDWFPWDTQDERPLSELLSELNGVDP
KIFDNIKLRKSETCRRTLKPNASRILNKQGECKGMLLSLDDVSVLEEQNEQLRFLATRDP
MTSCLNRRSFFEYLEEAWNSAIRCKHSISCLMVDVDHFKGINDSFGHAVGDDVLKSVSAA
LLDTARDSDYVCRYGGEEFCVLLQHSDIEGAACAGERYRAAIEALQFPQLSVTASLGCSS
GDLGAESAEQMLEQADQSLYAAKRNGRNQVARFDRLESTVQEIDAVAEPNNSTAEESLLD
SVKDLISDARDAGSTSVSVDRLNVAIKESSQHPSS
>A0A0M7APS9|diguanylate cyclase|EC 2.7.7.65|Roseibium album|TrEMBL
MDLLTLFSANLLLLLIFAISFQAMSLRVTQSTHWRSWAAANALLVAALVCFAFERVLPDL
AAYLLPNTLLLLGFGFHLYAARVLARLPNKVSDVFAPAFANLLVGMLAYLLSDPTLAYVG
GNVIFTILCVATIAAYTSKNFHGLISVIGLVLAFFFLAAVGGLRVYHGLTGDGATGPGMI
NDMMQDLHLMSAMLFVSLTGAFSTALSFEQVAQRHKEAARRDPLTGAYNRREFQVRLEDL
LHAPEKKSFGLLNFDLDHFKQVNDEYGHLAGDQALVKVVAAVKAQLRQDDCFARLGGEEF
AVLLPNISRENAAKVADRLRRRISDIRFEFAPEEFRITASAGIYHGDGNQLLMEDLMQVV
DESLYSSKNNGRNCVTFARALQATH
>A0A381DLU5|diguanylate cyclase|EC 2.7.7.65|Campylobacter sputorum biovar sputorum|TrEMBL
MERISNIFLNKPKHVGIVCFFIFFIIISIPIIYTYEKRNSLEYEEFRHHLGMAAYALSFS
VNPNLHKIVEDEQNASSDNYQKVTAPLFDFFALYREVYDIYTVVERDGKKYYVLDVANAQ
NAIAKDPIASPAKIMKELVETDNSDNWFELVESGKVYVNKDFETDNYGTFLSAIAPVYDE
NQTFIAAIGIDVSIEKYQEIMQKTRNIFILTIIMAAMISILMSIIVIALINYVKLVYYRF
QKVSNSDRLTGVYNRFVFIDIFTREINRVQRNKDNLYLIFLDIDNFKGFNDKYGHSVGDD
IIIFTAKKIVNTVRKIDIVSRYGGDEFLISICGASDEFIKDIIDRVMNQKYDFVYAVNKN
GIEEKLVVNFSVGYTKYKDGDTFETMLERADRGLYISKDFGKHRATFVEK
>A0A7T8JB38|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDEQQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDRGATQEWEKK
>A0A246S1V5|diguanylate cyclase|EC 2.7.7.65|Halomonas campaniensis|TrEMBL
MRYKDKYQLAAEWQTLLERTPKPLRQAVETLVESHGDYFADHFYRVMLEDPHASLFLSND
QVEQRLNPSMRRWLKAMFAVDHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAF
YQQINATFKSPLSPGNASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLHWENMLMFAVAAQQDLTTLPRLSNSDFGLWYFHKACHAFEGAPEIATIS
RHIQQVDREWLEVLLHEDPSQRLQALSEIRDAARMVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIEIARHSEHCFALLMVDIDHFKSINDTHGHDAGDSVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADTLLNVTISVGVT
LHDGHPDYHRSLQRADQALYQAKRSGRDRVVVQ
>A0A5U3G346|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSTEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A509DZ92|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MSKPNDFLNDFHWLMDVLRSIDVGLVILDKEFRIEVWNSFMQNHSVLRPEDVLNQVIFEQ
FPELPEAWFRRKAQSVFDLQISAFTTWEQRPYLFRFQNYRPITSLADFMYQNCTLIPLKN
ATGDVEHICLIIYDVTEVAVNRIQIQAANAKLHELSRTDGLTSLLNRKTWEMELDEEYRR
FSRYHHSTSLIMFDIDHFKAINDNYGHPAGDEVIRETARILKENLREIDIAGRYGGEEFA
VVLVNTNAEGAQTVAERIRTQVAASTVFYEDLSMNYTISLGIAELSSSMSDKTQWIDCAD
KALYQAKHGGRNNSVIFLGS
>A0A509DUD8|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MRTSRRIFSSYLIALFLSFSACCSADIRFDFFPIIAKVNNKDYSIGAVRDIVKDEKGFIW
IGGENGLARFDGQQVVVYNYDFDNNRSISSNFIWGMILDHDQVLWIATSNGLNRYNATTD
DFDRFYTDSAQGLRVSDDNVNQLAIDTGNNLFIATSSGLSVFNAERNHIQNYYIHSKGYS
GTNSNFIETLTVDKEDNIWIGTRSRGLKKFDLQTGIFHQVVGVPELAEVLNTGHISAIER
DHENALWVGTFNLGVYVLYPDGQYQHFTHDEDDQHSIGSNVISDIFLDSKNNLWVAADHG
GLNLFSREGNHFDRFTHNAYDTHSLGSNSPYEIYEDDKGNMWIGLFPFGVSFLNRSATLF
ANYQHKPSNPQSISNSSILSFFEDSQGTLWVGTENGLNSFDKRNGTFIRHVMKGEKNKNK
NFSAVLSLNEDVNGDLLVGTWSNGLFRYNTKTQESRRYYPDNRDPESLNSPFVWRILRDR
DNDLWIGTETGGLNRYVRETDSFEHYTADPNDPDSISSNQIWSVIEDPSGNIWVATQNGL
DKLDKHSGKFKHYTYDPSIKNGISGKQILCLYADSQGFIWIGIRDAGLNILDTRTDTFKV
LTTKQGLPSQTVFSVVEDHQNNMWVTTYNGVARINRESLAITSLDASLGYLTNTFNRDAT
YVDDQGRLYLGSIEGISILHPQAIQLERDPPPVVITDFRILNHRVPIGSASGERAILTRA
ITETDRITLDYSHTMFSFDFAALSYRGAENNSYAYMLENFDKGWNYVDNQRTATYTNILP
GEYTFRVKAANNLGEWNEEGTRIHITIKPPLWRTTWAYILYALAVAALVHFVNKHKHLRE
ISETYRTLSTTDPLTKIYNRAGIEQVADKIFSAQNNETRVGIMVIDLDHFKRINDSHGHD
AGDRVLQEFSSCVNDIIRSDDDLGRWGGEEFILLSTSSNIDGVTNLAEKIRVTIQHRVFD
ADHAQIHMTVSIGVARSKRDESFEQVVKRADTALYKAKAAGRNTVVLAP
>A0A554XN14|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MRQVLQHLEQLARLTRGKDRDSMDATLVEVLLPLLEARSVVLWEALPDEGQDRLLTRARL
ERGMAVPQSSAPWAPLADLPRVDDDPARVEAWRTGQSRVIVGEGEAHLLVPLITESERRL
LIEARLDHAPATHSVRVVEGMARIFENFINLLDSSERDTLTGLLNRKSFDDTFFKATQRD
PAPADAPGEQRRCHGPYWLAVVDVDHFKSVNDRYGHLIGDEVLLLIARILRSTFRHDDRL
YRFGGEEFVALVRACDAQAAAAAFERLRRNVEDYPFPQVGRITVSIGYTVVREHDTPSDA
FERADRAVYLAKAEGRNAVRGFETAVQIGEPSPQRGAERDVELF
>A0A377P6E3|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MLFVISAACFTLFYYKTETTVKQMEFLLKLSSARSDFLSLSASTFYNIDNRKTNERLKDS
QLQALQWSYSNYINLLHSFSIPKGLKESEEMASNELYNRVINARHGDSGTMVLPLNTQNF
RAIIEESLEEIKYTFHWQLILLILIPFLIAVIRTLHGLYYIDIFDKMNKDYYMDFLTKAY
NRRYIPKIKKRAGLDYVLAIDIDHFKQINDSYGHDIGDEALYKCTKIMQGNIKASDIVVR
MGGDEFVVFLFNATLQDAKHVTEQILHDINDEKLYISESVTAKMTVSIGVAKFDNDISTT
MKLADVNLYESKSRGKKQFTF
>A0A6Y3E533|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNDMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5U4NBJ5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSLANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A554XPT9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MSHVPLSDIPAPCWVTDGQGVLRRYNARLAEWAGLPDPGAQGDVAVTMTDWLTPAGRIFF
ETHVWPTLRRDGLIVEIFAYWQPGGRRSGAYVSAKRMEHDAEPQYLWLLFAAEDRQAFEQ
ALIQARQRAQSQAEQLQEAHARLRLLNGQLQRQIHQTQAENRTLSKLAAHDPLTGLGNRR
SLQALSQALASRPAPRRPYAVLMIDIDHFKAINDQHGHARGDAVLAGVAECLRRCARQSD
TVVRYGGEEFTLVLPDADVSQALVVAARAHEEIARARPGGLAVTVSIGAAAALSDDADLY
EVLQHADEALYAAKSQGRNTTVCHSSSRR
>A0A6G3F150|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHNTFVVKQSFLQWLHKRSNPRLVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMRDALETPVAFGVLHDAVKRFARLRTSPTWQIEVDK
QRTLPINGVSDAFVEKTTLLNRDDEFLDNELSAALEVGYLLRLASSSSGNEERVIYVSRA
GFFLETDTPENASDIVQRYYYLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSGSSAADVN
HFDAPELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLEEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGSLFERAKILA
KQCEQQALPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A7T1STC4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHDTFGVKQSFLQWLHKRSNPRLIVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ATVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRTSPAWQIAVDK
QRTLPINGVSDAFVEKTTLLKRDDEYLDNELSAALEVGYLLRLASSASRNEERVFYVSRA
GFFLETDMPGNASDIVPRYYRLVTQPWFTHQSERENRARAVRWFIPPPSSFVGKKPLITA
SVPVYYQRVWYGVVAMDFTLATLRRLLVEAVNDAPEGEYQLYDNRLTLLATSGSPAADVN
HFDPRELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGVVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGSLFEQAKRLA
KQCEQQSLPFSVIQIDLDCFKSINDRFGHQAGDKVLTHAAGLIASTLGAKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A2S0QZV9|diguanylate cyclase|EC 2.7.7.65|Zoogloeaceae bacteirum Par-f-2|TrEMBL
MNHSNTLESDWLELFDNVPEATRGVLREVVRAHKESMADAFYARMLGDPDAHPFLTHEAV
ETRLRHSMQRWLETLFSCTDRAQFALAMAMQRHVGEVHARIDLPVNIVARGARVLKAEIA
RHLLTAGLSGQALIDAVLYADNLMDLAFEEMSAAYVASHEHVARIDEAYRTFSFGQNLSL
ERERQRAALLDWENRFLHDMMTGSAGDPLPRLTESAFGLWLHHKATAIFEGAPELPAIRQ
AIRTIDDDLIPQCQAKLGGPERDTQRRLTKAVLSELGQLKFLLGTLFERFVELESGKDAL
TQLLNRRFLPAILSREADISRRQHKPFALLLLDVDHFKHINDQHGHEAGDRVLQHIASLI
LATVRAGDFVFRYGGEEFLALLVEVDLTHALRIAEKLRSRIESESVLMPNGASLKLTASI
GVAVHDGHPDYQRLINRADEALYRAKQQGRNRCVVSDA
>A0A822X394|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADSAIAAMSRVHERLVNMPLH
GAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGRGRTEVAA
>A0A826U0A4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMTHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRHHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A418GG80|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
GQFSTAEVRDKQQNILASWHYTHKEPGDTFSNFISHWLFPAPIIQPIRHNGETIGEVRLT
ARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRNFS
RRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFRSG
INTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRL
GGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEN
LQELADHNMYQAKHQRAEKLVR
>A0A2W6PIE2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLAHRAAFRS
>A0A827G9J4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCVAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGDRLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVTHSALHS
>A0A8H2DD28|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDKWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARKGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSYSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7A6KQC7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKVANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8F9BWU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQERLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLT
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEDACRAGVRICQLVDNHAITH
SEGHINITVTAGVNRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A8F9BQ97|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RCTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A826UT97|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNIIASWHYTAREPGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAVRETSALLFLDGDNFKYINDTWGHAT
GDQVLIEIATRLMEFSGKRHQAYRIGGDEFAMILYGVQSEYEVQRICTALTQTFHRPFDL
HNGHQTSMTLSIGYALTREHASAEKLQELADRNMYQAKHQRAEKLVK
>A0A2S8JUF8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSLSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A827GF80|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KTGRNRTEVAA
>A0A376JAU0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGGFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A3L3TIS1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLPLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A4V3QPA0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPETRNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCSNVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A377CL09|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRTFNSCI
>A0A6N8NEQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
FSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSG
IAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVS
RHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDE
ILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANG
EDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A0K4C8Y4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKVAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A377C7D5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPRKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMV
LYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQELADHN
MYQAKHQRAESW
>A0A6N4P5F2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRVCQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A7L5V5H1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLIFLRNGMREALVAPLDFTSMRNAVIEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNQLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNIPTRYYEFVTQPWFIGQSERENRQRGVRWFTSQHEHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSNPEHSAED
LFDPRELASLAQAMEHDTRGGIRMNSRYVSWERLDHFDGALVRIHSLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
ELCQIHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRSQDVAGRVGGEE
FCVILPGANLAQATEVAERIRLKLNEKEMLIAKSTTLRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNQVCASDSP
>A0A2X7GFT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLFHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5C9ABG7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
VKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGT
PLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEA
SENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEAL
>A0A377LJC2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVKERVYGLKQSVIDTAFAVANIAEYRRSVAIDLINTLNPTEEQLLVGLRTAYADSVSPS
YLYDVGPYLISSDECIQVKEFEKNYCADIMQIVKYRHVKNTGFISFDGKTFVYYLYPVTH
NRSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEFNAKNAIFTVSEAMEHFA
YLPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGVSCLYLVRRVINRGIVEKEAIINNH
FERVLDGGLFFSAADVKKLYSLYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVD
KFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTLEELLSIL
KEIVHFQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A376M648|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSYAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGHNRVFASDNA
>A0A376UDY1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPVDKGKVYRFGGDEFAVIYTGGTL
EELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERLKMLADERLYKSKKNGRAQISWQ
>A0A7D7HYD7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEIPPLAPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPLSGWWWLVLVGWAFVWPHLAWQLASRAVDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLKSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGDDEFAVIMSGT
PAENAITAMLRVHEGLNALRLPNTPQVILRISVGIAPLNPQMSHYREWLKSADMALYKAK
RAGRNRTEVAA
>A0A377LDW3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTGLYNRKILTPELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQA
IKQSIRKSDYAIRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAM
KENDTLHDAYKASDERLYVNKQNKNSRS
>A0A377CGH1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFQR
>A0A2X7G8J5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPAVINL
>A0A1I7D5E1|diguanylate cyclase|EC 2.7.7.65|Kosakonia arachidis|TrEMBL
MRQNSVVKQPKPFITLKRYFLPARVVNLCFLIVMVCSTMLTWREVIVLQGAYVTSQRSEL
GNVSNALDMQMQSAVDRLLFFRNSMQAALQTPLGFKALSSVQQAFRLLRAQAQWQIGFDN
TRTLPIYGVSDDFVNQTALLHRDDERLPDELTMAMELGYLFRLSANASMLPYQAYYISRA
GFYISTNPVQSEEKIIPTYYRLLMRPWFRGQQQQENRNRGVRWYTDQAHQGREKSGFVAV
SIPLDYQQYWYGVLVLSFPVRDINRLLVKSREGQEGGQYLLYDSRFNLLTSTLKEQGTVS
GFSADEYNLLLADMEHDTVGGRHLGSRYVSWQKLKQFGGVLVRIHTLREGLTGDFGHISI
ALSLLWLLFTGMLLFSWRVIRRMVNNMYSMQNTLQWQAWFDPLTHLYNRGAFFERAKILS
EQAHAENLSFAVIQLDLDHFKSVNDHFGHQAGDLVISHAAGMISNTIGEQDVAGRVGGEE
FCILLPGSTLKQAVRVAERIRARIRGKEILVQKDITLHITVSLGVCDAAENGDYDFESLQ
SVADRRLYLAKNNGRNQVCFTDGEPKK
>A0A377DSV4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKE
EETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAP
MLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHK
PLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKTAGGAAGTCCSTMTR
>A0A376J8T3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNEN
ADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKK
HKQKTPFVAHPALHS
>A0A1S7LLU6|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MIDSTLLDILWVTLCAGLVLLMQAGFLCLETGLTRSKNSINVAMKNIADFSVSITAFLVI
GYAIMFGPTLSGWIGMGAPFDLGDGTPFQLIFFLFQALFCSTAVTIVSGAVAERLSFRAY
ILISAMIAMLIYPVMGHWAWNGLEQGLSTGWLGSLGFVDWAGATVVHGIGGWFALALLLV
IGPRTGRFNGDGSVNEITGSNLPLTALGVILLWFGWIGFNGGSTLALDDRIPRVVVNTCL
AAAAGGVSALFWSLYRERIPRVLSAINGTLGGLVAVTAGAHALSPFAAVVIGLLAGPLVM
LAEAKLIQHRIDDAVGAVPVHLVAGIWGTLAVALFGQPERLGTGLDTLSQLGVQLLGIAA
AFIIGFILPYLILARLNRSIPLRVGPDDEALGLNVTEHGARTELSDFLDVLNQQASSGDL
GLRAEVDPFNEVGQIAHHYNHVMDALEEMSAKTQAIVRTAGDAIITFDPVNGRVTSHNPM
AEQVFNCTALELIQSDLGELAPQLDINDVWLKARLETEGKRLDGEIFPLEVAMTRASGHG
RSILIGTFRDISERKRTEQALINSEARFRTIFENAALGLALISPDHRIIDANPALLGMME
LPTDASLGGHLADLAHPEDQKEVFERLGRVIAGDEVKEICEVRCICSSDVTIWTRMAISR
IALPDATTPMVVAIVEDVTQRKRLDDKLRLAATVFESTRESVVIFNADGRVEQVNRAFGR
VFGYRGRESRGMELKLLLSSRYEADFFEQIKAHLDTSDHWQGEVMARCKSHDLTVMWLSL
AMVRRPDGSPQNMIAVWTDLTQLKEQEEAIWRHANFDQLTGLPNRRLFQDRLDQALGQSR
RAGGKVALLFLDLDRFKPINDTLGHQAGDELLQLTAQRLEKCVRKSDTVSRLGGDEFTVI
LQNINHGQELTKVAQGIISALTEPFELDAGEATISTSIGIAVFPDDAEEQEGLIRAADAA
LYQAKDQGRANHQFFTESLNQQIQQRAEMEQGLKQALEQHELFMVYQPQVGVQTGKLLGA
EALVRWRRSDGSLTPPDQFIPMAEESGLILPLGEYVLRSVASQVAQWQQAGIAIPPISFN
ASPRQFHVDGGGLPELLKQVCSEQAIAPSSLVVEITEGSLMSDPESAISVLDSLAEMGVD
VELDDFGTGYSSLARLSKLKIQALKLDRAFIQGLPLDRDHRTLVTAIAQMAKGMGIEVVA
EGVEEDGQLNFLRRLTCQRAQGFGIARPMEAEQFADYCQRISQQERSEQAPFIPELAYSN
P
>A0A348AR25|diguanylate cyclase|EC 2.7.7.65|Methylomusa anaerophila|TrEMBL
MIASDKYIRKDILFFNLIMVFILAVIAIVLLYAPTMGTFNLFIPFACLLFNMIVSHNLGL
QRGLMAGIVLTFAFGSYIIYETMIINRITEVNFAYIAWLFFFPLSSILAGQLSLVVSNYR
RELENKKSLEQLVTIDASTGLYNSQGFFRKLEEEFVRAKRYKTCFSILLIKMSNFDELQV
IYGEIDSIKILQSVAGKVELQTRFSDIKALISADILGIMLPETNEDGARIVIEKLHQALD
RLTTEIRGTKKVIRIKPSIGISSIKESDTDVLEAYQRAKEELNYDRG
>A0A120DCU2|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MDERVASILEQLSKGRIPVVPPDVDYAVQLARLTSYLDAIRHFTLALSSGDLSQTMGQAG
MGPVVGSLKALHSSLKHLTWQTKQIALGDFSQRVEFMGEFAEAFNTMVVTLGESRAELEQ
AYERLNEDMMELQLMSAELQQSEERFRLIAESVSDVIWTLDASLDSFTYVSPSIASLRGF
TVDEAINEKFAQALTPKSYAYVQDILMQKLSFYSETGTLDSFSERIEIEQVCKDGRIIPV
EVVISAIISTDGNIKEFVGISRDITERKREEEKLKYESTHDSMTGLYNRAYFDDELGRIA
NGPLFPVSFIVADLDGLKRVNDSIGHEAGDQLIRGASDVLKMAFRGSDVVARTGGDEFLI
ILNMTDEELAAKSIGRIRIYQEQYNKNSGNMPVSISLGTATAYSAGDIPSALKEADKRMY
DDKVSRKQQRVG
>A0A2J7YJ09|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MILLPTALCQGLDYNVQATVQGPSERDHDRIQSGLFPLTRQANAYMALDPPTMLTISVAL
AAAAALYLAIEWRSVRETSLLYWSAGFATITVGSTLALLRGIGLLFIGIWFANGLLVVAH
VFFLIGVLRFTQERLSRAWLMIVLVWFALLLLPVGPQWSKVMLMVNSLLVASLTLKASFL
LRPHGKSLSVGAVQLRYVLLIHGLFYVAKAAIAITPGTLIDLATFGGLIIQVSLVEGAMA
IMLIALSMTGTVRYRREERIARLAARDPLTALYNRRALEVRAGHFFKDVSPAQPGALLLI
DIDNFKLVNDLHGHIAGDRLLIALSEMIRTALPERSLAARLGGDEFVILLSGASSERVME
LGSGLREQFQQYADKTVPTPQAVTLSIGANVFDQPPASLAALIEQGDVALYQSKRGGRDS
IRFFERTVVELRQ
>A0A1S7LJJ8|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MSEKPKTLLQRMLRRLLGETQTDPRGLLAPWYHSELVGTQRAVLMISRVRMVAAFFAFMT
PLWILLDIYYLPVDVWPALVVARIIATAAFAILAMIFHSSDRLQDAYVGLATLLAIPLSF
FIYSHALFSEYPTVLNDVGRSLVTGYAFLPFIMVAGLAVFPLTALEGAFYMVPALVAEAF
FGGFDLGTVSNDAHMGLLWLLALIGSVTLISAMSQLHYLSEIIHKSSHDPLTYAYTRGTG
GELMEKYFLLAQRNETPLSVIFIDLDNFKSINDAYGHEKGDEVLSAAAEAIHKSMRRVDF
LVRWGGEEFIAVLPNTKAEEMVYVQERLADSGLGLRPDGAPVTASIGLAEFGSDKPESLE
QFVEIADKRMYRAKTTGKNRLCYGDGEEDLTPVGLFI
>A0A485CA86|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MTPGGHDEGDRAIIMLAQAISAVIRKSDYGVRLGGDEFCIILVDYDESEAEHILLRIREQ
LTLIDQENRVSFSAGVYKMRPGDSLDEAMKIAR
>A0A1V6AKS7|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MNKSIKALIFPTDDPKQVLRISRFLMASAAYFICAVLCTFAYIAGFVTKEAYFGWLAAAV
SINIVLFVVFRTGLNQRMADPSLTALQMCSAIVMVMYVMMFANETRGVFLLIYVVILLFG
IFRLDTRRFLYVSIFTLLTYGGVIVQLHLYRPQGVNFSMEYLQWVVLAGVVILFSVIGGH
ISGLRNKISKDRSTIQRLTDNIPDVIFVFDTNLNCTYVSPSVKILLGYEPEEVLKQKPFD
GVTASSLDLTIRTVSEIIELAKTQQGEDISRTIEMKIYRKDGIAICTEMKFAIIRDKQKK
SFEILAVMRDISERKKMMEAIRRGEEKYRTILEHIQEGYFEVDLKGDFTFCNDSMARLTG
CTSEELIGMNHKHFTTKETAEKVFQEFNNVLKTGEPSRGFEWLIIRKDQTQRYIEASVTL
KKSSSGKPIGFEGMVRDVTERKLIEEQIKHLATHDVLTDLPTMRLAKDRLKMSISLAQRN
KTMMAVMFIDLDGFKEVNDTLGHDAGDYVLKQVADRLLSCVRASDTVARVGGDEFLIIAN
GIHVPENAEQIARKVIGVVSQPINYDGGQAVVGSSIGIALCPNDGQDMDQLIKKADDAMY
KIKKTGKNGYCFINPQ
>A0A840PUD0|diguanylate cyclase|EC 2.7.7.65|Ureibacillus thermosphaericus|TrEMBL
MGLSKKIPPFYRKVISIFLNSTCVIVLFYLPIHLNENYFVDMRLVPLAFLAYLQGWIAIP
ALLIASTWRFFMGGDGMVPGILYGMILPTFIALIFHHRSNIKKHYIEKIFIVLLCWFVSD
FPIIFIVPNGWEIFKDTAILRVSSIVVTSIILYTFIMQDRQRRFLNSHLEKMADEDPLTK
LVNKRKFYELVEEKVNTLKPNHYIAMIDIDHFKKVNDTYGHLFGDKVLVEVAKILRKYEC
KNLVVGRFGGEEFIVYIGESDLITAKNILEEIRKDIKYTSFPYSTVEKVNITVSIGLSQF
KGEMNLIETIYHADQNLYNAKRNGRDRLVYST
>A0A7X9VYS8|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. Bel|TrEMBL
MSSSNGAVPAWTGGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFY
STLLADAEAGPRLSHEIVSTRLHSGMKHWLRGLLCVRDQGDIAALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAERLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITDAVTRLDDVVLPQLMLANAQQQVPMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREIAISTRQGSRFSVLLLDIDHFKAINDA
HGHAGGDQVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGQEAALAAAEKLGAEIRR
HAFSIPEAGALRITASIGVATFDGHPDYAYLIDRADKALYRAKQAGRDQSVAA
>A0A378JQC7|diguanylate cyclase|EC 2.7.7.65|Legionella busanensis|TrEMBL
MIPPEIPENEAERLATLYKLKILDTEREERFDRVTRIACKLFDVPIAVISFLEAERQWMK
STQGFEIQEAVRKTSFCGHVILSDEIMVVEDTMKDKRFYDNPFVVGKPNFRFYVGCPLKI
NKCNVGVICLIDDKPRLIKDVDQHVVYDLAKMVEMELESLQLAITDELTGLSNRRGFLKI
ANYLFQKCQRENQVFNLLFFDLDKFKHINDQFGHAEGDKVLKTFSNCLLKNFRCYDVIAR
LGGDEFCVFCSSLNSADVANINQRLKDSLKCISTQGYSIEFSVGSIQYNPKEHQTLETML
SLADTKMYDDKKSK
>A0A6B2KST1|diguanylate cyclase|EC 2.7.7.65|Crenobacter sedimenti|TrEMBL
MQQDVPANPHYAREEWLRLIGETPPPLRALIRVLAETHRVALADHFYRHMLSTDEGRLFL
DHDTVNTRLRHSMQHWLVELFRCDGEADIDAAIAHQRHVGEVHARIHLPVHLMTRGARQL
RQQLYRLLAQQDLTRQDLTRAHAYVCETIDLAMELMNAAYTRSTARQTRTEEAYRHYALG
QNLSLERERQRASLLDWSQNVLFSLHLHDATSPLPSLGRSEFGMWLSHKAEVIFERSDEL
EQIETQLERVDNIVLPLLQQAADAGQRRLRSRELQETLDEIHFLLGTLFDRHVEVENGRD
ALTRLLNRRFLPAVLSREIQLHQRSQQQFGVLLIDLDHFKGINDTHGHEGGDRVLQQAAQ
LITACVRAGDFVFRYGGEEILVVLVELGHDDLMRIAETLRSRFEAQAFTVTNGREIRVSV
SVGVALYDGHPDYQYLIGRADDALYQAKRGGRNRVVDADAMT
>A0A448W1Y4|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MQTNKKSKNIIGIIQSFLILILVVLIIFMMIQINRLQGTARVINYAGLVRGATQREVKLE
ITGNQNEELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAARN
KGYENTDIVNMSEIYFSMADETVSSAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTL
RAMQMAMQNRLLEQKAFIDAHTGLPNKNACNDLLNKKDIITDSTACIMFDLNNLKTVNDT
MGHSAGDQLIINFAKLLRSVIPEKDFVGRYGGDEFIAVIYHTSEAKIKEILKSLNREKDR
LNSYENQIPIDFACGWALSSDDMSCTMQMLLDAADAYMYKNKQICKKYN
>A0A8G0X3I9|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MLKRNSSLILLLWLWMCSTPSFATLLSIDESTTTPLNLTPWLMVSHPASAKEFTEIQALP
KTDWHNFTSKDIQKLSGHDFWLSFSLTSPDDALSRILALDNPLLDKVTIYHLVNNKLANT
VLMGDTFPYNERPFLSNIFLYPFKLNMDDTHTFYLHIQTEGSAAVSLNLWSSNDLAQIAE
STAVEHGFQLGVLAAIGIFSLFIAIASGSFSYSYYSGYVLSMTLLVATINGFAFRFLWPN
WPILQQVMVPFLLPIVMAFALMFTEKILQLKYLNRRMLLTCRYSAVYILCVGLTTPFIQY
GTALYIEIISVAVLSLVLMVFAISQAINGHKLARMYTIGWVSMLTGACISSLLYLSVIDL
NLKPQTPVMLGLTFEIIFMSLVLAIRYNDERKAKLRIQQEALKQAQKIRSAREEALKAEA
ESNEKLEQMVQERTLELEITLRELHEVNQKLTEQSTIDSLTGVKNRSAFDKRLIAESRIS
RRQETPIALLMLDIDRFKLINDRFGHLAGDEALRTIAQTLQQHLKRPTDLVSRYGGEEFA
IILPNTAEDGALQVAETIRDAVSSLHFEWEGEVIPLTISIGVSADIVTNDQHSTKLLEQA
DKALYQAKNSGRNQVSLYSSVPSKTST
>A0A3S4QF37|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MQLPPIPENELQRLATLRALNVLDTDAEERFDRITRLTRRIFALPICVVTLVDANRQWFK
SRQGLEVTETPRDISFCAHAINHDGVFIVNDALKDPRFFDNPLVTEPPHIRFYAGYPLTI
QGEYRVGTLCLIGNEPREFSDDDIETLTDLGQMVEAELLFIAQNTLDPLTMISNRRGFEL
LAYQSLASCRRTNAKAALVFFDLDFFKEVNDSFGHRKGDQVLYDFAHILMAAFRESDVIA
RLGGDEFVVLLSFVQPDTVGYAIERFKLLLEQYNQQRPQQRPLETSIGVAHWSPESDMNL
EDLLDTADRAMYENKALHHLDKP
>A0A4Z0YA09|diguanylate cyclase|EC 2.7.7.65|Caproiciproducens galactitolivorans|TrEMBL
MTLKPKLAAACVLLVSLSFLPLSFTAFVSKMNRDLQSSVSRNMIENAAQSAAAITAKMDE
SSSVLRTLATYLGEHGNLYDKAAADATQAVLNSHPFLQISVADLHGDSITNDGLKRNIAA
SESFQQAVKGKATITGSESFPNAKKAFLYSVPIYSKQKIIGVLNGTASADPIAEQLDNPL
YEGKGTRLLIRHDGTVVLYSKKAADSAVQNFYSSLKCVEPDKMSVEALKEQIGRNSSGTA
EFNVDGLDSFIYYQPLGAGNWYLITIVPSNVILPQSNYMIRISALLAFSTAFAFILLGFY
AVLLLRKKNNAIEKSIRELSVLTSNIPGCVQRCKYDGNLTIIYCSDGFYYLTGYSREEVT
RLFNQQFLKMIYPRDREAVKHSIDEQLHAGSVIDIQYRIQKKDGTLVWILERGQLMVESG
KEPELYSLLIDITEQRVIMQELEISNERYQIVMDQSDSMIFDYDILNKTVLNSTGGRQIS
GGGYAIKNFPESFLNTDVVHPDDAEAFRQMFESVKNGEPSAESECRMKSENGDYLWYNIK
ITTIFSKEGKAIRAIGRISDITCQKEATQKLLFKAQRDGLTELLNKIATQNLIEQALNDN
EPCALYMIDVDHFKEVNDNLGHMFGDAVLADIGSKLKKLFRTTDILGRIGGDEFMVLLKN
VDDHALIVEKAMAITQCLQQTFNTCYSISGSVGVALFPKDGKSYAELYQKADMALYEAKR
SGRNRFVLFHDRADSSETCPEHGKKNIP
>A0A1F2PT52|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MVGTSRFLRLLLVLAVVLAASLIGILTRPPGLLATFWCANAILLGMMVRWPVLIEWPTWI
AAAVGYVCADLITGNSLSLAVQLNGANLAGVTVGVLVLYYLKRTPFRLVDSQSLVWMVFV
SFVAATGTAATAGALDRLLRGQSFTDTFFHWGATEVMAYLLVLPLILTLTIPSSLAEFRS
KLTAKTVAAMSVPLLATAACVPIALSIEGPIALVLPIPALLWCATRISVPSTAFVSVVWS
VWSLMMAGSGRLDIGDQAASTWNEDVITSIAVTLIALGPIAVACATEERRAAERELFLAV
EFDHLTGVLSRGAFLGHAESELAAAARTQSPVGLLMLDLDHFKSINDTHGHMTGDSVLAN
FAERAADRLSDGDLIGRLGGEEFAILLPDCSYARAVDVAEAVRGAQVEYSAESEVTSTVS
VGVAWVDHATPTLTTLMSVADEALYEAKRAGRNLVKVRRLGNDALPQRNSEPDMATRTYR
KPDIPRTIRRGFGREGVVDGR
>A0A2T3W340|diguanylate cyclase|EC 2.7.7.65|Pectobacterium punjabense|TrEMBL
MNELLNVNEQRDNGESDYNQVVTSEWTQLIATTSQKSFGLLQTLAAQKASEFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILSNTGDHLADLILYQKKIGQIHARIGIPID
LVERGARRLKWQLYDNITQVTDDKSLCFDAMRYASISMDIAIEIMNKTYSQSHDLAAKNE
ESYRLFSILENASIERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIAKIITETDDYIRHYSNIALLTQQDYAPLLKTVRSKIYKINILLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKAVNDTYGHTA
GDNILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHTIHL
QNGESVTMTISAGIAVYNGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A1J5NQK3|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MPTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVEEGKLVGIITSRDVRRFHPNR
LVADAMTRKVITISPTAPLTEAQKLMVKNKIERLVVTSENNIIGIITYAQIMLELGKYTD
SLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKEYGHIYGDNVLRQATIILNN
LINMNEDTLCRYAGDEFAIVTTRSLVAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
>A0A6F8XDM1|diguanylate cyclase|EC 2.7.7.65|Halomonas meridiana|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
RHIRLVDEQWLAQLGDPDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKAINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRDRVVVAAVTE
>A0A0T9TCE8|diguanylate cyclase|EC 2.7.7.65|Yersinia aldovae|TrEMBL
MSELDSLFALYSDACVTYATLSISYFALSKNSPFSYNGEVWKRIVYGLVSGLVSLYLNQD
QWVISGSFFYSFELIPIVLVTFYGGWLSGLTAILINFSFTSWVTLDNILITIVFIPLVLF
RVWERKSNYIFYIAIILIAIYHIAVAALIVKHELIWTQIIIYQFISALCLAICYHALDFK
ERHIYTYFTMKDRANIDKLTQLNNRASADYRLATIHNRRQACGLMILDIDHFKSINDTYG
HDCGDIVLTTVGALLSHAVRDEDFIGRYGGEEFIVITRSYDPQTIKSVAERIRERVESLD
VLLPDGRKIKATISIGASLYLPGMSMLKALKMTDEALYQAKRQGRNQVVYSRLMPFSPLG
DRHFREERRRRS
>A0A378J2G1|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MKNFNQRVLLNLFLLILFFLQIGVNVSSYVQIQHLLNAKQWVLHTQELISAINDLWGNIL
EISVYTRGYVITGDANSVQALNNASAAASTKVQNLKRLIKDNPKQLERLNHLSTLLKERI
HFSNSVIAIYQKKGEEAAEDLLTKQRGALLHQLQTVIFTMINTEKSLLNARDDELQKTSD
TALSYIKMTNTLTFVLFFLFLGIFNIQFSRTVKLIQRRKQAEDQLKGIISGTNDSIAAID
NNYNLIAFNPSYAQDFLQLFGKSISLGDNLNDLLQHLPAEQTNLITLWKKALSNKKFSII
EELGDSKLTRNSYEITYSPIHNADNILIGASQIARNVTERLKIEKEMERANAQLTKNIEE
TRQRNHAVYLLNQLSSTLQMCLNVEETLEPIAMYGQKILPTTAGSLYLAHPSKNYMDCMT
GWGKPIIEEKIIGTEQCWAIRRGQIYHYYNSGQSIPCQHVKAVKPIPCYVCIPLQAQNEN
IGLLYLEFLNSQDLNEKEFRQLVENHEQLIISIAESIALSLSNIKLHVSIKMRSIRDPLT
NLYNRSYLEEFFSRELQRAKRQNNNLAIVMMDLDHFKKVNDTYGHEAGDIVLIEVANLLA
RNIRETDIVCRYGGEEILLLLVEVNSAEEVYERIDQLRQEIGKLEISFQGKLLERITASF
GIAMMPEHADTQSALIEIADRALYQAKKQGRNKVVYYKKT
>A0A0K0HBX5|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori (strain ATCC 43975 / DSM 13772 / NCTC 12419)|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQSQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDATEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWVLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A1S8PWN3|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MDNKLTSKEELIIKMEELISNNEGPFSIVVADIDDFKNLNNLYGNSIGDEVIKKLISILN
NNLSSTDMVFRSGDEFNILLVKKGAERSFMELEEIRRYLSDNTFNLDENSDDNVYFTLSF
GVASYPRDAKNVVELFRVADSALFRAKELGKNRVCLSEAESMVLKSNYFTKTQLDRLSRL
SKATDRTEAFLLREALDDLFKKYSK
>A0A5B9TPV8|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum multivorans|TrEMBL
MHLMIMIGELVFLIIGALFLVRALSPIKRLISELPDGTLKRRWRLLSNLTLFFLLFYFVF
GYNLWLLRESITVLSMLGSLMLLLGGIASYVMGQLALQTANDVKDMAILQHESITDALTG
LKNRRYFDQRMSEEVALSLRHKLPLSLMLLDVDHFKKINDTYGHQIGDEVLSSLAKLISG
MVRDSDIVARYGGEEIAIITPRTSKEEAALLAERLRDLIEKTTVAMVGTTQEVVQVTVSL
GICSLSPVITDKDALIEESDQALYLAKKYGRNRVVVSNW
>A0A1S8RLV9|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MEPVNVRKKVDILITILIAYFFVLCLSYKVFELDNSFENYIMLEVVMIIALVSYYTNVTL
ALVVTLAADFIYMSYKLYLNFLGNINIDFYSYYWIFLIPSTAILMSLVSRNIFALQIENE
SLINENSELVMIDEETNIKNQRALLMELPIYMKLSTRHKIPVTLLIVKIKFAEKLRSILG
KEEYKFLLIQASQVLEKSLREEDIKYIIDDKTFGFLTITDISGAKVVKERFRENINKYDF
TKGSHYKKVKLDIQIGSYTFDNSIKDPLELIRLAEKELEYDIYE
>A0A174SMA5|diguanylate cyclase|EC 2.7.7.65|Clostridium baratii|TrEMBL
MEDYKKLFENLEMDFKNYKKDAISEIAGYKRANEDLQKQLAVLYNIAEVSKYISSNIRDD
KLVLMINDMIVGLLGVTNSCIYMKENDVFRVKVSTYGSDINLIEEEKRKIISGEDYLING
DFIRKYDEIDNAIKSVLGIPIKIRDNYIGYIIVEHTLKHYLTTEHKMFLSSISNQIAIAL
ENSKLYRELKDAVIKDPLLGIYNRKYFFEKAENIIKEDKSNYAIVMIDLDNFKTFNDTYG
HQFGDEVLIQTSNVIKNQIRDLDIFARYGGEELIIFLNNVKNHNDIYKKVNNIRKSIEEN
VVTMGDVKAKVTASIGLAFRKFEDDSITDVISKADELLYKAKKTGKNKVVIDECELK
>A0A7X0PDF4|diguanylate cyclase|EC 2.7.7.65|Acidovorax soli|TrEMBL
MATYEQQMPRRVYPLRVLGMGLGGVVVAVVLWQRQAAVGAWIGMVLPCFVWPHVAYRLAR
RSADPYRAEIRNLLADSALAAAMVPLMHFSLLPSVLLCTLTMVDKITTGIRGLWAKSIPA
MLAGGAVATLFTGVHWSPESPLPTIVACLPVMALHTISVSVVSYRLIRKVSQQNLLLDEL
RRVDTLTGLYGRGHWQEEAEAALRRHHTRSEPACMLMMDIDSFKQINDQHGHSVGDEVIR
AVAHVVRGNVRATDCAGRYGGDEFAILLTGMAVEEAVAVAERIRAQTEAIRLRDMPALRM
TTSIGVAAAHPGHGTLRAWMDAADAALYVAKNAGRNRVTDSAAPAGAAPAAALSTSDR
>A0A849AWT0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5378|TrEMBL
MNNECMAMLAEQWEHICQNYSSDDLLHAFQFIQDHSLILVEEFYKKMLVEKESAEFFSDD
LIQQRLLNTLNAWLLESFSVGINKRYSEAVQKQHKVGHVHARVGIPSWLIMRGICEIERK
VFELVAQNPQQDMFTVCSYIVQIMGFSTEIMCRSYEFNLEKNNDIKHTYRLFSAMQDVAS
QKDKQRSSLLNWENELMFKVFSDELKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVSVIID
RIYQIDLLSQQVLNAIEKDKAIQLIQDIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLNTIVSREINFSRKNNTPLSLLAIDADFFKRINDKFGHAAGDLALQFIGEVLLESV
QGSDYAFRVGGEEFLLLLVDSDLGRAQEIAENIRRCIQETTIRTTMGSSFNFTVSIGCAL
YDGHPDYQKFLDTADTALYAAKNSGRNRVYLAQNELQVAVANTPESVQL
>A0A7X3M4X5|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. Taur|TrEMBL
MPTSPLTPRTGNPFLPVHLCFLAVFLFSAFLTVHEAIELKNNYEERQRAQLAEIQKNLDS
RFQESIDELTYYERMLNYALLHPLDSSQTREAITRFQQLRQQTTWQLKLASLRSMPLNGV
SDSWLMRDPLLLRNSDHINAELRAAMEFSFIMQFSDPGQDFHSRFWYISRAGFFISSRPP
QSPQELIESYTTMTERPYFRDQAPDNPQRGRLRWSEAYQGEFNEGLMMTVSTPIVSHGYW
YGVLSMDFTQARIHGLMAEARHSLLQGKLLMVDRSLNEITRLHAPNDEPLTPEQQERLES
RIRQLPGGVMRLGTQFASWSKLKNVDAYIVNIQSLRQGMSQELGRVSLFLLGMWLLFVLL
LLVVHQVIIRLVRRMDDLSAKLTWRANYDGMTRLLNRNAFFEQFVAISARSQQQQTPLAV
IQLDVDHFKKVNDTWGHAAGDQALIRVAGVISHTLRKYDVAGRIGGEEFCIVLPETTLAD
ASAVAERIRARLAAKTILVNASTTFSVTLSAGVTGSEEQGDYHAESLQATADRRLYLAKT
GGRNRVVAED
>A0A084ZPD5|diguanylate cyclase|EC 2.7.7.65|Trabulsiella guamensis ATCC 49490|TrEMBL
MQTFLEKMKHEWTVLISRTEKRVLTLSQKLATKNASAISKRFYDTVLTDPQAEEFLTNEQ
VERHLKKALAKWVTEVLSGTTENVDQLIAMQQHVGQMHARIGIPVQVVEMGARVLKKFLF
PLINDMECSAEEKFKLHGFTTESIDIAMEVMSRTFSFSDTQSSREDENYRVFSLLENAEE
EKERQISSLLAWEVEIVYKIMLDAEVCSIQSFSRSEFGLWFNHKGRHYFSGLTGISSISK
LMLELDEFVQSIKNESKSPSKKQKLINYVLQVHNSLSQITTLLRDLFDDVSRHEIGMDVL
TRLLNRRFLPTIFKREIVHANRAGCPLSVLIIDIDYFKEINDGYGHNIGDELLRKVSQAF
YDSVRSSDYVFRYGGDEFLIVLTEVSETETLRLAERIRSKVEKQAVNTPDGSLLSVSLSI
GAAMFNGHPDYERLIQSADEALYRAKSLGRNRVELWRPHSNTADKDR
>A0A7R6W9M3|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MLSNITAEQAFSWSISLTKQIDFNCLTNEMVTILTSISGVDEVNAYEVYAGRQVRSSGES
DVTEKVIRRFPVDFTLVEQDDEYIELLSNLPSGDALQVLDYKEEKIALMQVRHCIGPDRA
ILVLGQINEVMLAIFQHLLALYTNQVILHDYKERDLLTRLPNRQTFDNRFFQVCDYFREH
QLHRELNDKGSWIAMLDIDRFKRVNDEHGHQCGDEVLLHFSQLMEQSFRYNDFLFRFGGE
EFVVILNLVEMNFAKVVLERFRESVAQYDFPEVGKVTVSIGATHIDSESMPIGLLGDADA
ALYHAKHSGRNKLVFYEAMERRAI
>A0A7R6W9M9|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MKILIVDDSKAIRLLVAQCVSPFGHEVVHKDTGEGAVEYVQDNSVDIALMDVEMPGINGF
EATQQIRKVKGEDGWFPIIFLTTKDDDDSYTQGFLAGGDAYLPKPINPLRLQLQISAMER
IYHTRKKLKEAQLELIEANKALLHLSMFDKLTGLANRRNFDDTLEKEYKLAKREKNPLTV
IICDIDFFKIYNDSYGHQVGDDCLESVGECLSQVVGRPTDLACRYGGEEFTFILPNTNLQ
GGSAFAEKVRQEIEALAIEHDGSKVAPHITLSLGVATYNGQYKSGDEITKAADDALYRAK
ESGRNKYETA
>V5C805|diguanylate cyclase|EC 2.7.7.65|Methyloglobulus morosus KoM1|TrEMBL
MGFFSKSSDKNNDSDQDKWKDKYLNLLDAQDQTEKAFKVEQELLCKTVVRLSFAASGVDP
QLEPYLERIRSHIKNGVDSTKLKTELEKFTDALSRLKSASASNHQEQGSDVSLLFDFLLQ
HYTSDKQQQNLNLLKKSCQPLDDPKRLFSAIAKIIDAEEARPVDNEPDELANEENQAYQN
LIDPVFVSAQLVQLFEHIEIPEASTQKAQIIKQQLTSQGATLSFESTMDNVISLLIEINA
NNQPKQQDIDKFLNHISDQLTALGLAVTDSGIALMDASFSRSKLDQSVSDQMNDLQNRSS
SATQLEPLKQAITSHISQITKEIQEHKQKEAVQREKYQCQLEELSQKIKTMESETGELQS
KLIVANTNALRDTLTDLPNRLAYEERLKMEISRWQRYHTPLCLVVWDVDYFKKVNDQYGH
QVGDKVLVHVASQFTKYIRRADFVARFGGEEFVMLLPHTNKHSAIKVAEKLRSLIEQSEL
TTNDTTLSVTISCGITQLFKGDTHETAFERADQALYRAKELGRNQCCIL
>A0A1J5N138|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MFFKRKNQTVFVKTSTGNRQAVRAGLPIFIILALTMSPLLTAGSAIARQLDGGQYLTGFG
TMEGKSLYQRQAALGSGSFPDGAGRFPALRAQATGGVPNIPDSGNDALLLKLFAGGAVLL
ALVAFGAWHLALAVARRRQFEGELFEVAMFDALTGLPNRELFYDRLNESMNLSARYERRL
ALLHIELDGFKEVNDTLGHEAGDELLKRVGALLTGSVRRSDTVARLGGDEFIVMLNEITN
VGDAVLVGEKLVSALRAPITLREGPATIGASVGVSVYPEHGASADLLIQKADQAMYVSKN
KGRNTCTMAARTADAP
>Q8EF08|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MSRDLLQTAALNLKKAVPLMLKHQIPTTPINYALWYTYVGEQNLALNAQLDTVIAHYNTC
PPVSSELLYRQYVADPVELNVRDMRLNLEAMATELSQSIKDTSLDTTEFQTCINSNFSKL
NGIEEGALSVEQVLDLVRNLVKESDNIRSSTEFLTTQLQKAQTEIDALKQKLEKTEKDVL
YDALTGCLNRRAFDADIAGMIAQAPEGTCLILVDIDHFKAFNDNYGHQLGDQVLKAVAKR
LQEACRDGSKLYRFGGEEFAIIVPKSQLRITRQLAEAMRRGLEKLCLKDRRKDQLVDNIT
ASFGVAQWQERQSVVQLIEKTDKLLYEAKRLGRNRVMPINN
>A0A1N0G0R1|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MWADVALAVGAALLSDPTARICAIVYLGPVGLLPTFFLSRRALVAHCAFATSLLGAVLAV
NVLSGGARMFEQFFYAAPVISAIVLVPAVIQLVLEGGRDSILSAALAADRDPLTGLLNRR
GVTSAMDLLHRGRLDAIDIVVVLMDVDGLKELNDTHGHGAGDMTLKAVADMLKARTRVGE
IAARFGGDEFLVVAFPGRGEDIESTIRRVSAPRAGIDYWTVSVGAAWQSRTGNKVDLESL
VQQADHALYEAKKTRGMLDPQR
>A0A259ULS6|diguanylate cyclase|EC 2.7.7.65|Sporomusa acidovorans DSM 3132|TrEMBL
MYRYRTIMLKSLPVILGILGLLFGLSCYLLEKHAISNEWHYFYWSIFFVIQAIVGIAYGL
LIRKLYHFVYTDSLTQLWNRKYFFEILKQELRCPDTSATTFLFMLDMDNFKCINDTFGHQ
AGDEALKALARVLQNNIHPTDVAARLGGDEFALLLRNATQETACTTAETIRQTVNSKLAK
YNSSVSIGIVSSTAATGSDALLALADQALYRAKVHKDCTIFSK
>A0A5H6DM15|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanleyville|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NDQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A178X1Q9|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MQHVTDPGQSRGLSRVKHWEFWSHPVRVRAFVMTVVLAATVVTVAAAVSARVTFEDIRSC
LVLVGLGIGAAEMARQVERRRRRFADTPHVNFSSVWTFAASLVLPGALTVAVVVALYLHL
WLRSWRGIPGVHLHRTLFSACNVILSCQMAAWCARGVSVVPLEHDLGVMSLLGAAAVIGV
FFTVNSALVGTVIGLSLGTSSRRRLTGPANENLLELATVCMGLVTAVLLTLAPWLVAFLV
FPLYALHRSALVRQFEHAATRDSKTGLLNIASWRALADSELRRAEKTNGALSILLIDVDH
FALVNVVHGEDVGDRVLKATGAALSSVVRNTDLCGRLGGDEFVVMLPGNNADEVLAIAHR
IRDSIATVEVAPASGHSPRITVSIGAAAYTTAGTDLDDLLRAADNALFAAKDRGRNRVVV
S
>A0A7W3HP45|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00013|TrEMBL
MFPNTMNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VAQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHREFTNLKADAILAGMWIGIMGVNL
LPSTALLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A380U9V8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter haemolyticus|TrEMBL
MPHPKAALKPHSLFQLFLLFAGVIFLCCLLGIATRHLTFLASFWPANSVLLGLLIRFPQT
RHPISFIGAIVGYLIADTTQDTPFILNICLTTANLLYVITTLALYVRFSQIIRSMHHGYF
YLFLFSFCCIGGLASALFAAILLPYLDTPFALGSFWEDFGYWFTSEIQNALLLLPALISM
PNLTAFKQCLKELKDTAIQTVLPLVAVVISIVIAYYDAGPGYLLYPIAPLIWCALRYQHF
SVTIISSISCAFIIYHVSQNYLLLYPDNYLNNTISTRLGLIMMTIAPLTVSSINKVRSKL
IEELQHTIAHDELTSSLTRRQFLQSLQILQEQAQNAGHTSAFLMLDIDHFKHINDSYGHQ
IGDRALQHFVKTTQTLLNPQDLFGRLGGEEFAIFIANTNESVAYQCAEKIRQHVSESPIQ
LEHAQVFSIQTSIGICINTPEKNYSTEQLFKHADDALYRAKRQGRNQVIIST
>A0A156LCE0|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MGEKVSTWFVQVSLAKKRALLVLLILVQASLLIGHLLYQRGYVEDNAARILRNTAILQSQ
QFDTSLNAMRYQMRFIGNAFLLNHTVTPENAQPFLQGELKRAWLDGVVVFDEDGDFLSSR
ALFPFERALDASTLAQASFRQHPLFTGFRRDEVTESLFYWQSNGTDKNMLGFVMFRAVRD
AHGRFLGGALGFFNGNTMNDMFRKMEVQGFDLGQGGAMAVLDRDNAVQLARMGANDGSQL
NTSDPRLAKLLEYASDTAQVQRYTSPIDGVERMGVFLNLNERKWVLAVGLARKDVLHGWY
YQALWTALAILVISITQWFLMHYIHVNALQRARFQQEARLDPLTGLANRRQFDEWSLRAC
NLARRHQQPLCLMSMDLDFFKRINDTWGHDGGDAVLKHIGNALPALVRGSDIVARFGGEE
FVVAMPQTSLETAAEIAERVRMSLASQNVDFNGQTIRFTASMGLVCMTPDELEIEHGVQS
ALARADRELYRAKREGRNRVCVAS
>A0A5P9EPM1|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MSLKTRLLGLASLLIILAASASWLAYRELSEDIIERWGKQVTEIQVRYDSARLLQSLERE
IGLARQMAQSSTLLQWAASPDNSELTSAAIRQMETFRNNFRDNSYFVALRENGHYYYNNA
DNQYAGDQFRYVLDPEKPDDAWFFQLIEEGRDFHLNVNPDQELGVTKLWIDVLMRDESNE
ILGMVGTGLNLDTFLQDIVDIGQEGITTLFVDYNGAIQLYRDHNYIDFASIIKPEGQKNT
VDLLFEDRQDKQQILGMLQMLKQRNGEDGAVESGFVTIDGRKHLAGVAFLPAIGWFEITL
LDLNALVPTSYLWPLVAVFLVALLVSLIAFHLIIQSRILKPVLSLESAVMRLREGRFDLP
YLPKPDNEIGRLVDHFEKMTRTMRDTTAELEHKVAKRTEELHRLARVDALTGLKNRRGLD
EVIEQEIQRAEREGKGFGLIWLDIDHFKTINDTRGHQAGDDILCRVALWLKAAVRPYDHP
GRWGGDEFVVLLSPCDKDTLEQIANRVRTSVEQESQRTGTSVTISVGGYFSQPGDDMDTL
LRNADHALYQAKRGGRNRVCIHAATGEETHPA
>A0A4Q6X6P0|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia sp. UYCP14C|TrEMBL
MVDACLALRRLYGGFSDLELDHRRTGMRVRSAAETRAKTTAKEVWHRASSRPRRTVILCF
AVVFVVTLILAVHQYFLVRARELDNRSHRLDIQARVLDVAVRNNRQHLQFLRESGERFLA
DRAAQPDRTADASVQAVLQAQDERVWNLQVGVTDAPIRGVGTQQLAVIPGLHRDEPRFLE
DLRLAQLMSRLLAVQFPMGTGLERAVFASPTGVVVAYPAIDDDEVVRILQTFGSSRLLQL
ANQHPLAYEVTFDPIRGRKNPAEPRLLFGTPVMSNGVVRGLLFFVIPQRIVQDYLRTDTT
PDETHAVIDRSWTPIATSGIALAAEHDNWLETLPPRWHTLSASTLFQTGTGMLSAGQDFL
LFRKLETADLLLVDHVPAASVFRAVVHLSSALFAGVWLLMAFLLWSTLFVVDRLLSTQMA
LNQRLRELSLADPLTGLANRRRLNEEFGALARRDVERRIALLMIDIDHFKRVNDTWGHAA
GDETLKHLADVVKLTVRPGDLMARLGGEEFCVLLPDTNADDAARIAERVREAVAGNACVL
QEATLLRSAPGREIRFTISIGAAERIADDCRDLERLIAVADQRLYAAKASGRNRVVACES
TQS
>A0A5P9EFJ5|diguanylate cyclase|EC 2.7.7.65|Marinobacter sp. THAF39|TrEMBL
MQATAKDAILGNTLAKNQTKTKVPMRSGIPSINLPAQPEKPVPDTSTSAEGLQAVLDNLD
ALVYVSDFETHELLYMNAYGRRIWGSIDGRKCWQVLQDSDGPCSFCTNDLLVADDGTANA
PHVWEFQNQLDQRWYQCRDQAIQWTDGRLARLEIATDITERKNMELALHEAHERARAAAF
EDELTRLRNRRAFFEFGNQLLSRALRQQSPTALIMMDLDHFKQVNDTHGHEAGDEVLRKV
SSTLGENIRDYDILARMGGEEFALLLPETTEQEALDTAHRLLSALTSLTVDYRGCAIQIS
ASFGITSLGRQDQRLEDLLHRADRALYRSKELGRCQVNLDAPL
>A0A212JNX2|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacteriales bacterium|TrEMBL
MGRRTAAIGAALGAGLSLLAEVLLLCDYGSRAPWMLPHAVLLCILGAIGAGLIVLASRLF
LQAPQSAAERGQFYLLSHFANTFLFEYRFQSRVLTFSDNLPQELGLGLHLEGADCSLRLC
KLIHREDRHKLRAMAENPPAPKDEALQELRLLHSGGSYVWYECRVAATYDRHGRPMALLG
RFENIDARKRREANLVARSTRDDLTGLLNRSAVTLRVEEWTQSPRAKEGGALFMLDLDNF
KSINDSQGHATGDRALRLTARVLRDTFRESDILGRAGGDEFLVFMPGVSSPELASSRAER
LCRTLSEQPFDSDNVFPFTCSVGISLFPQDGNSYAALFEAADAAMYQAKREGKNSYRLSS
SLADSCI
>A0A608MII0|diguanylate cyclase|EC 2.7.7.65|Salmonella thompson|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8G1NF91|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MSDEAQRWKEKYLKSIEQQEKLERRWDARLDLLRRGLVRSTLAAEGTDRVVDQCMKEMRD
VVRTDDMDAGLAALLPRLEKAVLDSEQRRETRIEQVSTALTALVTQLQSLPLPRDVAQPL
KKFAKQLDGRVSQAREMPLLLSELSGLQGKALSQLATPAEPGRPGLLQRLFGSRDSEETP
APVAQAAAVAPPVQPQQAPVTHEAAPAPEAPVTSAEPVATASVSQAPIAAPVAEPFKAPE
PIPEYLAEPEVAAFEPARILTESPSAPSEPETAEPEPEPQTFTPPPVFAPAVPTAINPDE
LIHPGDTPPPVILDSLPLPEPIAQALAAIDPEQSEHDILYALPDSPEPSYSSVAKHIEDT
LIGLLDDLTLPERHRPQAEAMRDRLKNGLNWYELLPILDDLATLMLAINDSGQHEFEAYL
QQLNERLEAFQSNLQAASEGHADNSSAARAMDTQIREQVDGLQNSVQEAADLDDLKQVLE
NHLEGLLGTMDQHQKQRDAREQEVAGRLKSLAERVAHMEQEAQGYREHLEEQRQKALIDP
LTGLPNRAAWTERLEYEIAQWQQHGNTLSLAMLDLDHFKRINDNYGHLAGDKVLKIIATV
LRKRLRGSDFIARFGGEEFVLLLPATPPAVGAKLLETLRAAIEACPFHFKGERVTITVSM
GLAAFRPGEHSDLVLKRADQALYRAKNAGRNRVELG
>A0A8G1JY51|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 3-2|TrEMBL
MRRDKSTGRPTLGSVIGRGNLIVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKAAATEALALIASTEEVADAQVLDTQGQLLARWQRPENGLISELEMQVAR
VILEKPINLPIQHQDREIGRILLIGHGGSLMRFLLSGLAGIILCTAISAWVALYLAQRQL
RRIIGPLHSLAAVAHAARSERALDRRVPRAKIAELDNLGTDFNALLDELESWQTHLQSEN
ETLAHQASHDSLTGLPNRAFFEGRLIRALRNAHKLNEQVAVLFLDSDRFKDINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKTEDAERIADKILASMDTPIAL
PGDSSVVTSLSIGIAVYPDHGVTPGTLLDAADAAMYQAKRLSRGAQFTAGTEYPVDSVQT
RS
>A0A379Z4I8|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MICSCIISSCAILLISEMYAERAELVLQHQADTDTLTGLLNRRAFMRQVALQREQPGCWV
LALLDLDFFKKINDNFGHDAGDVALIHVSKLLKKALKPQERLARIGGEEFALLLRLDEPG
TQALQQRGEQLLESLRQQGLEYQSHYLQLTASVGLATLDPGDSASEALKQADKALYQAKI
NGRNRVELAGTVLQPLKRKSQS
>A0A380BGL1|diguanylate cyclase|EC 2.7.7.65|Shewanella algae|TrEMBL
MDKHPGYLFRLLLAFVLLQFSVGAWAAQVLDNSYILKAEPQQLAPTSFEGVPAWIRAQQE
TSLSLSGGSYWMVNPLRVASREQSWVIDVRNSIIESIDLLLLGQDGSMQQAHSGYDADYQ
YLFDYGRRFTIKPGIDYWLVVKVESRYYSSAPEIRLAPEREHRLSADRHATAVVLCLGGL
IFIACYNLFIFFTTRDKAFFWYGLYVLAYFCGWALTFHLPVHLFQFRQLELHHLFFISLP
ILNILFYNNFLQLSLYSPKLWRLSRILLWACVLALPTSIWLLSYTAIIASVLIMLWIGLA
IVCGNVCLMKGFSPARYFIMAFSCLLLPAIIILPGNMGITPDFFEYAELATLLGGTADAL
LLSLALASKLKLLSEERQEYIRKLGIAWERARSDSLTGLANRLAYDESLADTCLSSGIPK
PGYMLVLLDIEGLKRVNDTLGHGEGDRLLLAVAEELKSWSVAKLKPFRIGGDDFALLLPE
AEAQQLQNLLPRLEQRIASEGFAELCVNHGSATSTDKEKIQDWVRAADKDLYQCKSLRRR
ELHARQLAAAEGLPR
>W5SDM8|diguanylate cyclase|EC 2.7.7.65|Borrelia miyamotoi FR64b|TrEMBL
MQNFDNLEKDIKNFSYIIDKDFLVWPENSLLKPKNIELIEKWGLKKALKMQKTFFNESAM
QEAKKLINVEYDKESIASYHILISNLEEVYETCKKNKKIYYQDVLPTVKKVIEFYKKNQK
TFIKYIKIPKLLSDYNTIHPVNTAILTVALGSEMNLNNHKMVELCTAALLHKIGFLFIPL
KISEKKEKLSDEEFEVIKKYPTLGHKILSTTNFSQSICSTILTHKENLDGSGYPNKLKSE
NINIESNVIGAASAYSAILLDRTYKEALNSGASLIELIQDADKKFDKRVLKLIIKVLSQC
PLDFIVELNDKSIAKIIKINETNTNTPYIQYIIKDNKVVTCSKNQNYVKSIPKTETGIKK
ILRKDEIEFLLKKYSLEKM
>A0A8D6MWE8|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MVLEGAYVTNQRNNLENVADELDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEY
MSKRHEPIWSVALHNRRTLPVYGVSDDFVDSQSSLSRNDALTGNELMAVLELGYLLRLVE
NNRGFNERMLYISRSGFFTSTTLPKNAVQAQTLYTHAIAAPWFTRQSQRNNPGRGVFWQT
VLDEHAQNDDPVVTASIPLDFRHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSR
LNLIASSASGNVLTLLSAREQAMLSYAFLHQNQGGIRLLTRYISWQKLNNFDGVLLRIHT
LQEGVRGAFGTITIALTLMWLLFTLMLIISWQVILRMVRNMSVLQKSLEWQAWHDALTRL
LNRGALFERAIATTRMCERTGRPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASN
IREGDLAGRVGGEEFCVVMPDTTLQVATAIAERIRIRIYSREILLCNDTSLRISASLGVS
SSDDCAGFNFENLQSTADHRLYLAKQNGRNQVCFNDLPSCAGLRK
>A0A857EWI6|diguanylate cyclase|EC 2.7.7.65|Yersinia canariae|TrEMBL
MDLSAVEKPAPDNKTILHIAITSIVVFLLALFCIRLSEQSENLAPLWFPTAVLMVALFHH
PTRYWSWQLLAAGISIVAANFILYGISWFPLPLTLINLAESAAGAWLLRRLLQPKDPLNN
LFSWLKFSICTVILVPLVSGLAAAWYLAPQNGNFTPVLTVWFMSEAIGMLALGPVGLLYR
RGYFNITTKTKALFDMIWMMIASLTACYIGLIYLPFPFTFIIMALIWVSIRLPRFETFTI
CFLATLLIAMMINFNLFTLPTDTKLSVQAFSFIPLLMVLIPPHAMAMVMHSFRMEKEHIV
ESENRFRNAMEYSAIGMALVSPEGKWMQVNQALCKLLNYSQETLLTLTFQQITHPEDLSA
DMKLLDDLYHGRIPSYSMEKRYIRSDGEVVWALLVVSVVRDHEQQPLYYISQVEDINDLK
KSEIINRRLMERITLANEAGGIGIWELDLRKQVISWDKRMYELYHIPLYTPVDDKVWRTH
VHPEDINRVNREYSAALKQRQPYRLEFRLLLPNGEIVHLRNQANMVCDKKGNILRLIGTT
LDMTEIRNLTEALHEEKERLHITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALG
QPVSHIIKLTNGVDGPEIDNPIEHCLNHRPYSSLNESIVLHHRDGQHYDIQESVAPLKTL
EGGVVGAVMVFQDVGESRAMMRKLSHSASHDNLTGLPNRANFENKLKAAIQVSVELNQQH
ALAFLDLDYFKAINDTAGHPAGDALLKELSQLMRQHLRNSDCVARLGGDEFGLLMLNCTL
PHAKAITQSLVSMINGYHFYWEDKLYRIGASAGVTQISSSNNQRSEIMAQADIACYTAKH
SGRGQVFLYQPRQKQLLARQHDLLSKEDVENIISESQLTLQLTPTAPPKTPLSVCFYQVS
FVVNRPQNMNVSQAEFQEAALLYGLLPQVDGWVCEQLLVTQAEAINRKGMSLAIPLSEIA
LLKEDFRQSLLALVQQTALPPQSLYWMVDESTLLQYPFAIGNFLAKLQELGCKLIVKEFG
HNLNDFELLAEHTIDYLKFNSDLIAHIHINQMDEVLISIINGTAQRANIATLAGPIELAP
TLHKLVAIGVDLADGEMIGPTAPLTEVLNSGYFAIK
>A0A2L2JI43|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. SGAir0187|TrEMBL
MQRDTFVVRQTFLQWLHKRSNPGRIVNLCFLIVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRLLLFRQGMHDAIETPLAFDVLQDAVTRFNTVRMLPTWQLAVDK
KRTLPLNGVSDAFVEKTTLLNRDAERISHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFLSTDTPDQAGNITARYYNLVTQPWFTQQSERHNRARAVRWFISTRSSWTQDERTITA
SVPIYLDHYWYGVVAMDFTLSTMQQLLAEATEDRTEGEYQLYDTRLNMIATSALAENAVN
HFDERETAQIAQAIEHDTGGGIRLGSRFISWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKLLA
EKCHQQSLPFSVIQLDLDHFKSVNDQYGHQAGDKVLSHTAGLIASVLRKNDVAGRVGGEE
FCVVLPGIGLEEARVVADRIRCRINSKEILVKKSTTLRISASLGVSSAGEKENYDFEQQQ
SVADARLYKAKQGGRNRVVWNDHDKK
>A0A2H5ZWU5|diguanylate cyclase|EC 2.7.7.65|bacterium HR32|TrEMBL
MQAEREACGPRAVVTMQGIPVLQEAAMRVGKEGASPGPAALRHEAGWRGSRASQQTLLEA
ARRLLRPMDLAAVLEEALTLVHTLFGYRISAVLLVDRETRELWCAAQRGWGSEAAKRRYR
VGRDGVVGWVAYTGWPYYAPDVQREPRYLEVAPGVRSELVLPLRPDGGETVGVLSVASTE
LEAFSEDARGLLEAYSLLVAAAVQRAERDAELSRLALTDPLTGLANHRALYQTLRRELAQ
ASRYAFPVSVVLLDLDGFKQVNDLFGHPYGDEVLRLVARMATEACRGMDLPARLGGEEFV
LVLPHAPKLAALQVAERLRRRIDETALEEGIRLSASFGVAVFPDDGNTPDALVRAADEAM
YRAKRAGGNRVEAS
>A0A658NZB5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. AAK_AS5|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITSLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQGHAARSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEAIEEQAFRAGLVDPALSKALDRRVFSEFFQNAAQAVASKGLSIALPLSAAGLLNTELI
DELLEHLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A4U9D7L6|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MRYFNKNAQMEEIGGLIAEVDNLISGWKSTDSHTGYKETQNLLQGIHIHCQQIGSQLGVI
FSSLTQMQNGKDALTSLLNRRYLPVVLKHEVTLAIEYERPMTVAIVDIDHFKEINDSWGH
QVGDRAIKHVADLLSDNIRSSDYIFRYGGEEFLLVLVETGAHEAHVLLERLRKNISQLAF
NVGGETEIAITASIGYAIHTGHPDYNLLLRDADSALYAAKRDGRNCVKMHEGGSGG
>A0A737TY41|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z4,z24:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A517R4P1|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium Pan189|TrEMBL
MQSFDRCAGGLSADVLYRLMRAMNSPDRDQADRIRDVLYVCLDRLGLDLGIVAKINGEAY
HVAYVANRGSVEVGEGASFRCADTFCETTIRCEGTVRFVNASRSEWARHPAYQSFPIDSY
IGRRLVVGGKVWGTINFSTFTPRFGDFSPAELELVTLAAQWFEEKLNRDALEDRLKRRES
EWSALQAASPLGMFQTDEQGFCLRVNEQYTKLSGYSHQECSGDGWSRAIHPDDRERVFQE
WHESADLNETYESDHRFLRPDGSSIWTHVTASPILVGEQVTGYVGTVEDITRRKEAEDRL
RYAALHDPLTGLPNRALLFDRIGQAMQTSRRTGRHDFAVVMIDCDGFKAVNDNHGHEAGD
LVLCEIADRLSDTLRTTDSVSRATDSSLASRLGGDEFVVLLTNLASPADAELVAKRILKS
VSRPIETPRGTFKLTASLGVAVTTSEVGTPEDLVRAADAALYQAKSSGKAHVVFQQFQPE
FTKRPASSKIRRIRCVEAAVEA
>A0A752MD97|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A845SS91|diguanylate cyclase|EC 2.7.7.65|Acerihabitans arboris|TrEMBL
MDANNATSASRSNGIGIFIAAVALLIFMLSVLCLNLNHHTDPLSPVWLSTAAMLAALFYC
PWRYWPAMVIVGGLAIIAAYALMSSHTLDSLPLTGVSLAESALGAWLLKLMLNPRDPLDG
IVPWLKFFLVGVLLVPSLGALAAGYFADAAQTDYLTFVPRWFTAEAIGILALTPVGLLCR
RQALLQMIKQRSWLELLLMIALTLAISYFALRFLPFPFTYIILPLLIGAVRLPRFEAFGL
FLVTTLALLIILGTGLINMDLPPSTKLAVILHIPLLMILIPAHAMAMAMYAFQLERGHIS
QSETRFRNAMEYSAIGMALVSLEGSWMQVNKALCRFLGYSAPELKKLSFQEITYADDLSS
DLTQLNDLVNGHIESYTLEKRYIRSDGEIVWALLAVSLVRDQHDQPLYFISQIEDITEVK
HNNIINQRLMERITLANEAGGVGIWEWDVEAKIMSWDKRMREIYAVQPAESVSYEYWLER
ILEEDRPLALQTLADSLEKHKPFLLGFRIRNPGDDIRHIRAYANTLMDENGRVERMLGVN
LDMTGEVRLREALYEEKERLHITLDSIGDAVISVDRQLRVNFMNPVAENMTGWRQEKAHG
RHIDGIMHISAGVDGPRLPMSMDHVSGAAHGALTIEQDFVLNNRKGTLFDIHYSCTPLKN
LKGDVLGAVLVIKDVSESRQLLQQLSYNASHDVLTGLPNRASFKQHLDAALLAATREKRR
HALVFIDLDRFKQINDSAGHAAGDALLLELGLLMQDNIRQYDCLARLGGDEFGLILTDCP
LPEAQALAQRIIDAVNAYRFYWQDQLYRIGGSAGVTLISEDNFNAQEVMAQADTACYAAK
HSGRGRVLSYEPPQPLAGAAARRATLSHERLLDMMGNDLINFQVEAVASPLARLSVDFFL
LGFDIQAPALQAAGALPVPVSQDELTIAARAHDLSSAVDGWLLKQLFYGHGAAIGGQGII
LALPLSVQGVCDPTITDELLSLGERHPQLNAQMLIISLDGKDFMDQYPAITRAIDPLRQY
GYKIMLTQFGADLGVFNKLRAGQIDYIRLPDHFIGNVHCSQMDDIMVRVINGHVHRLQAR
SLAGPARLPATLDTLGNIGVDLATGETIGQRLPLSAMLDKGNFASR
>A0A378ZNC9|diguanylate cyclase|EC 2.7.7.65|Paenibacillus thiaminolyticus|TrEMBL
MMGNKRNAYIGFGMLTMLVTVYAYIFYLIGDVDIVLFAALLIQVIFIWWFGRKYEMVKRE
AERDALTKVYNRRFIMKNFAKIKAKAKRKSQTITIFFIDIDKFKYINDHYGHSTGDIILK
KTADILRKGFEKKHYIARWGGDEFIVLMLSDGSSGMKIMQRYFADKLASLSKELKINVTF
SVGFEVCSDKHRNLTDILDAADRKMYRHKNNKVPAAK
>A0A0E1LXA6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1303|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A5C5ZR28|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MPSENLPLLFLGLALAGALLSLGYFFGRRRRRVRVVNDGLIPPLVDEDDRQRIVGMLQSL
ARWTHEYSDNVSDYQSNLKQISQDVRRNLASAHNESQSSSRSAGEARAASDTRMLSMITQ
IMSTNEELQSRLDAAEKQLAEQTSQIESYLTEARTDGLTGLFNRRAFDKKLDEMFAEYRG
GGGSFTLILVDIDHFKSINDTHGHPVGDVVLQRIASQLSNYLSDAEIVARFGGEEFAILT
RSPLRNAAKQLNQLRIRIADEPIQAGNVAAVVTMSVGLSEPRDELVIGPIVRRTDAALYC
AKNRGRNRVYFDDGSGPQLFGAPEVVRS
>A0A0E1M519|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1303|TrEMBL
MKKEYLYSISAVIFCILLGFCLIIINNGTLYPLSPGQYHIITQSTYLMMMVALFFIDIIA
FLFMQLYFIYDRNNFSHCILGLAFFSCIIYLVLTIIIVQQYESDTVSVVSIHNSIMVHYF
FRQLSFCLIIYLALCVRNRRKNTAMIAGNKTIFLICFACMIILPVISYLISHQYFFPDIT
DTALYKFDFVHIETYIKFIIFLWLGLVFSLFYTRAVNNDIWKGILLIAVSAVFYNIFVLF
IVDGHMHLWYLSRMAEMFSKLIVVSVFIYHIFKVLKSTKQLSNLDPMTKIYNRNFFFEKI
NELLSTGDTYSSGVFIIDIDHFKSVNDTWGHPAGDRVILAVVDILKQGIRTTDILSRLGG
EEFGIIINNMDPSKIKILAERLRRHVETQTNNTTLYNIPGGVTISIGVTLIRDKSLNASD
IYNATDNALYKAKSSGRNKVVFSEMA
>A0A1A8XVS9|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MRAVAVLLGDGADVGILSRDAQGETVLRVFSGVTIMNSAVFLWPEFLQDVRSDGKLVTRC
IRGRNCGALMLQSSELGSEQTILAYDVNQLDAAEHAEEIASLARMYSNQIKLLDYSELDS
LTRLLNRKTFDETFDRLLTVSSTDMPDDDFDDRRSSPDMGSQAWLCVVDVDHFKRVNDSF
GHLFGDEVLLRMGKLMRKTFRGADRLFRFGGEEFVVILNAETEALASTGFNRFRESVESH
EFPQVGKVTCSIGFTAVSNIDVPTDVVGRADEALYYAKEHGRNQVCCYESLVAAGAIAKA
KAVEAAVDEDFDIDALFG
>A0A1A8XX78|diguanylate cyclase|EC 2.7.7.65|Candidatus Propionivibrio aalborgensis|TrEMBL
MTHAMRESAYYDALGCLVMRLDRKTAIRFMNRFGLKLLGYERLDQLFGRPMSVVLPDNDA
QSATLAALIGNSERVFPDPFEAELLHCDGSLIPLSWKRSEQIGAAGQAAATILVGFDARS
MRESQATAAMFQTVTDNYSGSILIANEDNSILYANPALLHMTGYSFEELIGKTPAIFKSG
QTPDEVYRNLWETIDSGGIWNGEVINRRKDGSHYLECKTIAAIRDSQGHVQNYFAIGEDG
SQRHQLQQHIDKLLAIDQLTGLPNRTAFMNLLVAALNSAYLDESEVTVLHIDIDDFFVVN
DAIGTDEADLVIVEIALSIKGALRQADILARLGNDKFAILLGPHESGIDNVIHDVTGRVL
AAIHQPILLTDRPIYVTASIGIAGYPIDGGSASELLSHAMNATERAKAGGGNHCCRFDAT
TASSASGQRELIADLRLAIERNEMFLHFQPQVSLFSGAIIGLEALIRWRHPLRGMVSPGD
FIPLAEQSNLVVDIGEWVLGETLRQMRIWLDAGLPSIKVAINLAARHLLAPGLHATISNA
LAVQRIDPRHLEVEITEGAMMQDIAGAIRSTAQLKKVGVRISLDDFGTGYSSLAYLSRFP
IDVVKIDQSFVSDITTNPVNAAIAQATIAMSHKLGKVVLAEGVETEEQMQYLRRNECDEM
QGYFFSRPLPAEDIARLLQEGSTMNLYAQRGSVKRNTVLFVDDEANILASLKRTLRREGY
EIMTAGSAAEGLSLLATNDVQLIVSDQRMPEMNGTEFLSRVKSLYPQTVRMVLSGYSEIS
AVTDAINKGAVYRFLLKPWDTEMLREEIAGALRHWRELYASRRKDD
>A0A151ANA6|diguanylate cyclase|EC 2.7.7.65|Clostridium colicanis DSM 13634|TrEMBL
MGKCDGELKDKYKEEFLKLKDEFETYQNFAESTIQMITEKNIKLEKKLDSIINIVEISKY
INSYLSDKNLIPMINDMIIGILGATYSSIYIVENGCLVVKATNVQNKNYNFCEDEYKDLL
NGKAFIINSKETIFLKETSKSDIHSVIGVPIYLGEKFMGYILVEHGLNNYFGYEHIKFIS
NIANQIAIALENNALYNRIREMAIRDPLLGIYNRKYFFETVEDILSKNPMEIVAFVMMDL
DNFKEVNDKYGHQFGDKTLIQTTNIILHNIDDKNDLIARYGGEEIIICIRKVTDMEEVYK
KIDNIRIKISENVVRYKDIEKKITASFGISYYPIDGTNINEMISVADSRLYAAKKKGKNK
VINK
>A0A0H5LTX8|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MSSIKNKSAGQAKHHNAPTNLPTLGRVLGRIHLIVALVSVVTAGICLTLAALLALRVYVD
HNLHLVARSISYTTEAAVVFGDSMAANEALALIAANEEVDNVKILDVNGRELASWTKPDT
SPMHYLEQQVARCTLPDPVVLPIIHDGNEIGTVVIAGHGSNLLRFLLQGMAGLLLCLVLT
TAVALVLSRRMLSGVIGSLNQITKVAHNVSRHRSFGQRVPSAKTAELNALSDDFNELLGE
LEVWQAHLTQENDSLAHRAAHDSLTGLANRAFFEGRLSRTLGDCEPGEHAAVLFLDGDHF
KEINDNYGHAAGDVVLTTIADRIRALLRESDLVARLGGDEFAVLLAPIHHIKDVSIIASD
IHESMSQPIMLADGCEITMSLSIGIAIYPDHAQTPEALLQRADEAMYQAKKNFQSGGSII
AQPSDTSLTESLG
>A0A1E3WGR4|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MFARALLKNIMSARNHRFLAHSLFQYIDELLEPQSASIVSEPHSSEQPQSLYEQGDPTTL
NNYPDTFWSWVAQFDTSDGLIPLAMATCQWEGNSIINHDSYIFMIDNFSEARTYLILENV
EADKMQQASLENSLDLLQVIASRWQCVRAELEAASEYKQRDIKEAKYLDVIQQREKFIED
MKLVQRISVEISNPETIDDLHRIAVEAIREQLGFDRAAFMLLDIKKRCFSGTFGTDENGK
TVELQHTQYDLHQLEEAYINALFEGQDGLVVLEDAPLYNDGAVIGQGWNGMLILRDGDDI
IGWVALDNYINRSPITSYQKQMLESFGSLLAQIYIRKRQEQNVRMLHASMVELSRCMTVR
DVCKSAVTFGINRLGIDRLAVFLTDENCSYMQGTWGTDIQGNVVDESYYRSELVDRSIVN
NARSNPNEVVFEESVPIYHDYHIVGFGWTAMTMLTSSSGEPVAFIAADNLIRRIPLTHQQ
REMIRMFASNLTEVLSRTRAQEAVHVLNETLEQEVKERTKELQKANEQLELMAKMDPLTR
LGNRRMLESLLEDICVDDKGRGATYGLILVDIDHFGLYNNYYGHMQGDIALMRVGSILQY
HAQLSNEVFCRIGGEEFALLVVNQNEQQVVALAERIRSSIEEEAIPHADNEGRSVLTVSV
GYTVTNVAGDEFNFDALYGQADQALYQAKGSGRNIIRGYKMPLEAVE
>A0A149PW01|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia monticola|TrEMBL
MIVCFVTVFVVTLILAVHQYFLVRARELDSRSHRLDIQVTALDTAISNNKQQLQFLRSSA
ERLLADRTVQLDPNPGASLQAVLQAQDERVWTLQVRDVNAPIRGIGTRQLAATPGLHRDE
PTFLEDLRVAQLMSRLLAVQFELETGVERAVYVSRTGIVVAYPAVDDDETVRLLKNFGSS
RLLQLVNRNSPDYDVTFDPIRGRKDPTGPRLLFGTPVTSTNLVRGIIFFVIPQRVVQDYL
RTNTAADETHALIDPSGTPIATTGSTFPVNDENWLKTLPSQWNGLSAATLFQTRSGMLSA
GQGFLLFRKLDTADLVLTSYVSAQTVFLSVVRLTSALFAGIWLLMAFLLWSTLFVVDRLL
SMQLALNTRLRELSLVDPLTGLANRRRLKEEFDVLTRRRNVERHVALLMIDIDHFKRVND
VWGHAAGDEALKHLAHVTKIAVRPGDLTARLGGEEFCVLLPDTTGDDAARIAERVRKAIA
GHACVLQEATVPRTAPGREISFTISIGVAEMVADNRPDLDALIALADLRLYAAKAAGRNR
VVAGEFTQS
>A0A7Y0LR92|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MQNHDYIKMLNKKVKLLSKELDNRNFKLKSSNEIDFFSKMPNREFMYQYIDDCISKNVHI
GIMLLNIDNFKLFNDIYGYLVGENLLITLTQKLLHFIPESKGIVAYLKGEGFLIVLPNVS
NKELSTMGTTIVESARELKIQLPNEKEIYSNITFSIGGAIWNGESNMTTLMLFNQVYSAL
KKAKSEGKNRYTLFDFKDNTFYNKLENDKEFLSEISYALQTKQIEVFYQPLYNIKNNTIV
GCEALARWRHPIKGLLTPDKFIPLFEQFGLITELDLYLFEENCRNIRKWIDNNDVFVPIC
CNFSRLHFFNPNFPSMLKGITEKYSVSTSNFSIEITENILIENTNTIIQQLTELRSYGFS
VSMDDFGSGYSSFGMLQNLPFDIIKIDRIFLSHNLNDFKNTTILYSIINIARALGMLTVC
EGVETEQHVEFIKSINCDIAQGYYYAKPMECKQFEKLLSKGNNSEKMFIKYSDIGKALIE
KIFDGFFIMQDMKKLEANVTEDIQWFDFYNKTEITSFPKVIEHFEKHIKGKKFSILYKSI
TPHNTESDSLLISGEAVLSDEAAEHQKYSNFYFSANCIISENKLLLSKLHLDLINTAGYI
NEFESYSIPKMANTHLDESDILSQFYSMLPVGIIRYDLFGDMIITYMNEEMLDIIGYTKE
QFFGEMGGNLRAIVHPDDLDFVYKKSLEMIDTNKIEPFLYRFIKRDGQIATVMYTQCNLS
AIDGRSIAQGMYVDINKIKNLTKI
>A0A095U974|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp. RTa|TrEMBL
MSSSSTDLPLLPERHAGQACYLSASNEQAWVAVYQSVDAYTRGQVAAVVGDSLSELVDAF
YSTLLADAEAGPRLSHEIVSSRLHAGMTRWLKGLLCVREQGDVGVLMATQKKVGEVHARV
HIPIHLVMAGARILKNEIALRLRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRDVNR
GARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPGQSLPRLAASEFGLWL
QHKGGAMFESAPGLQQITDAVGQLDSVVLPRLMRGEEQGQAAVMPDLVRELQELVARIKH
LLNGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREIAIARRQRSEFSVLLLDIDHFKAIN
DQHGHSGGDQVLRQFAEVLHQSCRSSDFVFRYGGEEFLVVLVDAAQEAALATAEKLGAEI
RRHVFNIPEAGPLQITASIGVATFDGHPDYAYLIDRADKALYQAKQAGRDRAMAA
>A0A0S3PVJ7|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MDTDRLGRLQWAGGAAIVLGCLVLGLFLVFEARSDCTQYKAAGEALSHHHVATRLTHAIS
AERAMSALSAIDPNPDTARTIVTRRDRTDAELGVFKQMLVASFGAQGELQALMQRLEDRL
GNARDTVNGVIALPIDQRANSHVADVIGAMFAVCDIMSGLRDKIGQAVIKSSPDVTSDIL
LVTTASALREQGGRLGASVVLYLAPSEKELERGAVREFDEAIGRIAVLLSSLTGVLGPAF
GDADVERAASEMQNLFVATSVPLATQIVRGEAKAVYTSKSFADAFIPGLYAIEKVFEAIA
NASRRKIEAKRDAAYRKTVQAAIPTGAMLVISLAVVSIFRRRVFQPLAGAQEQIEAIARG
DLAHASFKSKVASELQSLFPGLALVRDNQLQLERDQQRISDQFDRLSETDQLTGCLNRVA
FLRRAKRVVEAANAKEIALAIVVFDIDELKWVNSAGGYVAGDETLKKTATELGHYIGEGD
LFARYGGDEFAMLFAARDRYSALATAEAMRRHIEKSLVTFGGTKTTASFGMAFRACDSGL
GLEQLMATAERRLVAAKAHGRNCVCAGDDDAPATATLPLGKPRNRPRNDRAQAARSTRR
>A0A450CRF9|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MKEQLIFNITNLVTVVFEAFVIHMFLSDFLGQKEGYIKIVRYAKLGFIICLGFCNLITLN
PKITMPLIFILIFSTSFLYKGNLKTRLFTTVLLSIFFILSEIVVTSIFVLFVKEGFEIMF
ENNSIRVLATILSKIVFLLTCKIICLFKKDVHLDMPIKYWLPLFLIPIFSLFLSVSIFDV
SKFFSLESLKFLSLISSVGILYINFIVFYLFKFIIDKTKLSMKYEILEKEIIHKEELRLS
NECYKIIVEQTDSVVFEWNIKENKSFVSQVWTEKFGYNNACKNIFKEIKDKDLVHSEDKA
IFESFLESIKKKNIHSQAVYRLKKSNGEYIWCRTSITSIYNDENELLRVVGVIVDVDSDI
KKFEELRTRAESDSLTNIYNKGTFEKLVEETIVMNTGDKKDALFIIDLDDFKEINDNFGH
PFGDFVLKTFADKIQASFGSKDLVGRIGGDEFVVYMQDYVTEVNLHKKAKELNRVLSDNY
TDLSFSFDASVSIGIARYPQDGTSFFELFKNADRALYSIKASGKNSYCLFEEELYVQ
>A0A450CHD1|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNKRNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPEGKVCWQVLYPEQNSTC
SFCKVLELLKNDKKGVLIKWYEKCNKLNRAFENYDSLITWQDGTVVHMHQSIDIANSTIL
NKAIKINEFNEISNTKEEKGVFNFSRDNFDYNSTLLYDALIRGTDEYIYICNMKTGVFRY
SPSQVELFDLPGEIVENPLIYWEKIVHPEDWNRFYKSNTEIGKNQMDYHTVEFRAKNRSG
EYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKIDSLTQLLNYHEFMSVFEDKISNPMI
EKLCIVLLNIDDFKNVNEMYDRDFGDNIIKTLAQSIQSILPDNAELYKLDGDEMGILVDN
VEENEILTLYDQIQNMIIHLQLWRKYGLNITISAGCVIYPKHGDTVKELYKCASYSLQYA
KEHGKNRLVFFSQEILKNKMYSLEMMRDLKASINDDFRGFSLRFQPQVDTQSHKMIGVEV
LLRWTNDKYKAISPLEFIPILEENDMINIVGAWVLRMALRTFRKWIDNYPFFKVSVNVSA
VQILEDTFIKDIVKIIDDENFPYQNLVLELTESHTVQNLSILQSKFKALQDLGIYIAMDD
FGTGYSSLEVLKFSPIDIVKIDRVFVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVET
QEEYDLVKQIKPDYIQGYLFGKPQTATEIFDLLKLDN
>A0A381IAJ5|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MANDITKLYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYE
GHNVGDKILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQLEALRENFLK
VFSKYKYLSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKFDKNDY
>A0A7Y0LSC8|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MYNFKYVKDSMGYVFGDKILIDLAECLKRYFRETDTVGRVGGDEFII
>A0A1V4XKQ5|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaB.Bin095|TrEMBL
MKLMNKTKKQLVAELEALQERVLELEALQERVLELEALERDARFAQREFGERMSGYFPQV
EHMNEAIYVVFDRKYEFVNRKFADLFGVAQEEVCSPGFDPMSLVAPESRRFVRDKFRQGS
RGEFTAQQYEFTGLTNEGVKIECETFVLYVPYKWGVAIHGMLRNITMRKRVDIELQRQRS
DLQIVLNSIPTSVFYTDREHRFIRANSAFCKSLGLPMEQVIGKTLAELFPNVPAEQLAPF
CEVNDQVIRTGQSRRGVIEIFPSLRGRRWIQNDRIPYRDAEGEIAGTICLAIDVSDYRET
EEKLWYLSFRDVLTGLYNRAYFEEELARLGHSRQFPISLITTNVDELAAINERDGIAAGN
ELLRRTARVLKAFRTEDVVARVAGNRFAALLPQADGAVAETALARLRESLAAHNRGHEGT
PLNLTFQVATAATSREIQQISF
>H8FTR7|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MPDYKQSHVTAQDPPLPSVAPSDPSGSIRVVTIYGVAAAAWFGLTEGVFANLTGGISGLT
KGLAFVAVSTLILAALLRRTMATETPRDRASSMARLARRLQAISEQASQAIYVKDECGRY
LLFNSAAERMLNRTADDVIGRDDHVLFPADEAAELMEIDRKMMAERRIETYDRTLTTRLG
VRTFSVTKAPLLDTSNRVVGIIGVSRDITELLMASEALRRSEARYRSMFENMLSGFASYE
VIRENGRPVDFRYLFTNPSFEVQTGLKNVTGKLVSEMFPTIKETDAEIYEMGVRVAETGQ
PEKHEGYFSALNIWFVSSFFMTEDGLLAIIFENITERKTAEQKIEHLAYHDSLTGLPNRL
LAQDRMTQAAAHAQRDRTMAALLFLDLDSFKGVNDSLGHSCGDDLIRAVAERLSNCVRDT
DTISRHGGDEFLIVLTGPRTSDAISTTAGKILAQIAQPFDIQNQTLLTTASIGIAVYPGD
GTDFATLLKKADTAMYHAKEEGRNTYRFFDERMNVGVAELLRMRNGLRNALDHDEFELHF
QPQIDLASGRVIGAEALIRWNHPELGRVSPDRFIPVAEESGLIVPIGEWVLREACRRAAA
WQKEGLAGVTVAVNLSALQFKRGNLKQTVTDALAEFGLDPTCLELELTESILIKDVEEVL
ATVFQLKSLGLKLAIDDFGTGYSSLSYLKRFKVDKLKIDKSFVRDLASDPDDAAIIRTII
QMAHSLNLRTIAEGVEDQEMLDRLRLFHCDEIQGYLIARPMPIDDFIAFVRAHSPSASDS
ASDRGTAIPILVR
>A0A174EL47|diguanylate cyclase|EC 2.7.7.65|Roseburia inulinivorans|TrEMBL
MYTKETSFSRRMKQAEQHAASLLQQILIFVLIFLVIFMMVQIQNLHGTAHVVNYAGLVRG
ATQREVKLEITGTADDMQIEYLDKILSGLKYEDGNYNLVSLKDPAYQQCLDNQIEYWELL
KEEIYTVREKGYENTNVVSMSETYFEYADETVTAAEQYSEKIAARIRLTEIISALDILLL
IFLIVQQQIQHIQAVRENHILSKKAYLDVHTGLPNKSRCEDLLNSSGFITEPLCFVMFDL
NNLKEVNDTLGHAAGDSMIANFAHILRKVVPEKDFVGRFGGDEFIAILYDTTSGQADELL
EKLHATIKQYHSSNMPDAISYAYGYSYSMNYKDCTLRNLLDKADHEMYLNKQAQKKKR
>A0A0T9QNZ3|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MNELEYLSTLYRDTCVTYATLSISYFVLSKSSAFSYRGDVWKRVVFGLVAGLVSLYLNQD
QWIISGSFFYSFEMIPIVLVTFYGGWLSGLTALVINIAFTGWLTLDNGLIAIIFISLLLA
KVWTKKNNRVFYTTIVLIAIYRMVVAVLIVPDKLLWTPIVVYQLISALCLAICYHALNFK
ERHIDAYFTMKNRANIDKLTQLNNRASVDYRLAAIHSSRKACGLMILDIDHFKSVNDSYG
HEGGDLLLMAIGQLLTTSVRDEDFVGRFGGEEFIIITHSHDPDDIKGVAERIRQQVEKLS
VELSDGRTTSATISIGASLYLPGMSMLKAMKMTDDALYQAKKQGRNQVVYSRLMPFSPLG
DRITRERRRRKSA
>A0A1E3H8N4|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MKDMSVGAAPGVRLRIWPKTLGLSLLSILASILVTLALEAVFVRPFFPGMNLYIGAGIAA
GVSAMLATPTIYVFLRMQARLKSLYGRVEQLAMADDLTGLMNRRCFVQTAERDFVVPGLP
VGALLIDIDRFKSINDRFGHACGDAVLMRVARAIAEAAGEGRLAARLGGEEFIVLGAALS
ETEALALAERVRAAVARQRIVFGTDVLSVTVSIGVALAADDYTLSALMSQADLALYDAKR
DAATRWCPTGRRWPSPHSRAVPAGRRRLKAPPRNRWAAPEAEPTRPPRDRRGRGGG
>A0A1Y6IPW1|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MSTTWLTCLLNEKGELVSSNQRHEDALSLENFTSWFFNSPSSLQPLQSRDFNSLLLSQEE
PVELSILIQEELWGGSLMRMHPIDGDFPEAIFLSLHNIAKSPVQILDEANVRLMQKQMMQ
LESDLHYLVDIIPGVIYQYERRSDGHACFPYISPQVETLLGVKPEVVAQDATTLLQAVHP
DDRQRVYHSVLRAEASQNEWECEFRVIHQGKICWLYGHSVPVHNDQHRQLWSGLMIDISD
KKTLELKLQRESTIDPLTNVFNRRYFMYSLNRTFTSGFKNKDCVSILAIDFDHFKKVNDQ
YGHDAGDEVLKQVTSAIKRHIRRSDILARMGGEEFSVILPSTEYKDAVKIAEKLRKCVEN
TAVHYLDSAIRITITIGVASAENSDLNEKDLLRRADRALYRGKAAGRNLVM
>L0RFF0|diguanylate cyclase|EC 2.7.7.65|Maridesulfovibrio hydrothermalis AM13 = DSM 14728|TrEMBL
MKLVYRYFSIILLLIILTVVSLAGTLFFHVGHSFTRIGEASRESMESTLVYNFIKEGESL
AAVLADAMIDPFLVHDRHLFSSLTNALKSIDFVQDVYVYSSDGNILSDGTYSMENYNEPI
VSIIPLDDMFSHTSVINQESGLIITTSPVQYDGELLGGVCIVMTSDRIERAISNLDEELH
KVERNSYEMLFRAGLGVVIFLLIGAAFLAYWTACRLSEPLKSLSDAMSKVGRGDFQLSLP
IERRDEIGSLGRSMLSMARELKNTTISRDFFNGILYGMRDGVIVTDENDNIVIINNAAEI
LLDSSMTEAVGRSIYDYIDEESYRNFKYEKNTNHKEHGLELKIVPKDGSERHVLVSSSKI
KNNEALYKVFILHNITERKKLEDELTFKALHDNLTGLANRHALINRLKVAIARFERDPQR
PYAVLFIDLDRFKFINDTLGHNAGDKLLIEISARLKRLTRAEDTVSRLGGDEFIILLNEV
EGPDSAAIVADRVLEVIAEPVRLCGENVVVTCSVGLFVSTDSSIDINAVLAKADMAMYEA
KKLGRGQFKNYEFDGALTTPEVFHIETGLRKALSNGSLQVFYQPILSVNSDETESVEALA
RWIHPDHGEIAPDDFIPVAEDAGLICSIFDFVFDEGVAFLKQVELETGRTIRLNINVSAY
QITNSTFAASVNEKLIKHSLDPERVTLELTESALISEYDIAKSNIEKLKELGVGLALDDF
GTGYSSLTHVLTLPFDYMKIDKTFIFKVHSRNRSSKIFQSILSMGQSLGMRIVAEGVEKV
DDLKVIRDRKCDLYQGFLKCKPLPAPEIIEFIKKGGNYPV
>A0A3S4I8S9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A7H4LVF3|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MPEREKNIHIQPSSSISRTHILPAMLAIVVVSSLCAFVSPPLGPWREILTNPGMYIDLLA
LLFLLFMLWSSTKVRMNHVAVNWVRYGLLLWIAGGTFDLMDEIFHQPRWMGYYCEDLLRL
SGMLLSAVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKEGRRLALMIVD
IDYFKKINDTWGHLGGGRSAVCPWQTAGEAYQR
>A0A1V6AFV2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MVYIAKDVVKMLSAMNNVFDVARIVNPWIWKICNFDSDGNISYEDYSCYRIWQKEKRCLN
CISMKALNEKKRFTKYEFVDDETYYVVSKPVDIKDNEGITNEYVLEIVANITDEVFFNAI
GKNELVDKIIKSEKLQYIDSLTKAYNRRYFDEKVYLTDFSENSRSEITFIVIDMKKFKNI
NDEYGHDTGDEVLRNTAKVFISSVRNNDSVIRMGGDEFLIVLQDCNEQSALDVVQRIKES
MKQIIYDSEKNLHAKADFGIAYTDSFVNNDAFIANLIKKADKMMYESKRVNN
>A0A1V6ANL0|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MDRKLNLLNNKKWNFEKLKSNNQSSIDEYNERTLSTLLLMGWVLTLLPLAAVPFSKTKAG
AIPAYLITFALFFSLYFLYKIPTVKKYSLIGLYISFSVLFLLGIYLSVIHSPNMRATILL
GGFVIMPLSLIDRSRYIIPFLTFWLIVHTILAFYLKPLYALDDTINCLCSAILGIYLGRE
LIQVRLVSFEARRLLIIEKQTDELTGLFNRRKLYEDLTMLETANLEKPSGFMMLDIDHFK
EFNDNFGHINGDIYLRHLGKLMSEFAQLNRLSFYRFGGEEFVIIAYKYKEKELFTIADNL
RKYLQNTDINGQGTTVSIGVVYCGDEQVFNYEDAIDQADKAVYTAKHLGRNQVFMKHK
>A0A2X4TD79|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTTEKRRAFCDAFETINGTHGVNLIRHNYPALHGTLQTAATQCTDN
IDDVFLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLKKHYVYFYDLINSQRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLSGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNITLKDLDSGKEIIINKSKNNLFQYVDYNHDIPGGLRVS
FSLDLTYFIVSSWKALAFYLLATALLLNMVRMHFRLYRDVTRENISDAMTGLYNRKILTP
ILEQRLQRLVNTGTPVTFIAIDCDKLKLINDTLGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIVRNLQIIAPDKSVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQRRS
>A0A7R7A0X4|diguanylate cyclase|EC 2.7.7.65|Nitratiruptor sp. YY08-13|TrEMBL
MKKEKIAIFFHNKNNEKLLYKYLSDKYEILFDAKLNQDEKIDLIIIDGVCLKKYQYQIEK
LKEEEKPVFLPILLVTTKKDIHFNKNEIFQLVNDVIIVPIISIELHMRLYNLLYIRELTL
ILEKESSIDPLTGVFNRRAMNEMLIAEIEKAKRYKRPLSVIFFDIDHFKKINDTYGHDVG
DFVLRKLVSVIRNHLRQTDTLARFGGEEFLIVLPEMDLQNTKIVAEKIRKRVETTDFEKV
KKITISLGVTQLKEDDTRQELLKRVDEALYQAKNSGRNKVVTVS
>A0A632TVK5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNRLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSGATQEWEKK
>A0A330LSY0|diguanylate cyclase|EC 2.7.7.65|Moritella yayanosii|TrEMBL
MSKKLFALSAQYFKKAMPLMIQYQIPTTPTNYALWYHYVSDNNSALKKQLDEKIALHGTC
TPAASEELYQRFIVDKREQELSQLRSELDAMTNELSSSLHDTLNDTNEFDRMLNKCLNEL
SGVEEDGFSIEKTLSAVRELVKESHDVRSSTRHFKSQLHEAQIEIAQLRETLLKTQHDAM
HDSLTGLLNRRVFSKEIETFCSNPSLNRNFSILMVDIDNFKAFNDDYGHQLGDQVLKVIA
KRIADSCQEGEQVFRYGGEEFVLILPNKTFTIARQNAESIRRAIERLSIRDKRTGKVIDN
ITVSIGVSENKPRDTSHEILTRADQQLYEAKRLGRNRVMPMPR
>A0A1Z5I543|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MLYFAKKSAQVIAIVISIACLLLPMASTGQETVNIKQFNQVIEQVEQLKKTDLVRSLKQL
TVYEKVLTALTIEQNLIYFKLLAEIQIEQNKYSSAKKTANQGLTIAKRLSSPSILISELL
YLKGFAFESLGYIAQARKEYKKGLEVAESLHNKVQVALGLINLGAIAYLTDDFKRSLVLL
NDAYNIAGQTDDEELKGTVNSELGIVYSYLLQDEQSMVYYQQSYLHFKKAGMILSAHTSL
YNIAINHIRNNDYQQAITVFNTIIAESNKDSPSDSMYSVYSGMAWAYQQKVDSNPEAAYR
YLLMAKQYLQATEKLDYQLQFYYDQAYMLYKLDRFDDALVSLSQVEKTLANNQGLSLIKK
ENYVYLIELKAGIYYKLAQFQHAFQTLSQVIILTDKLYENEDNRSIAQVRLKLEGEQADK
RNKILHHKKDLYNENLRAATLANEEQRFYLIISALVALAFAWVLVKLLQSQHKLKVAANV
DTLTGVANRRSLMKQAQQAFNFTQVKQDNLTILLIDIDHFKDINDCLGHSTGDKVLAKVA
YIGTNMMRKSDLFGRFGSEVFMVCLPKTRLKSALEISERIRSAVSQHSWPFNKLEKVSVS
IGVATLADDKDLISLIKRADEQLYQAKASGRNKVCG
>A0A6I5AG54|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQNVIATWRYDAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGDRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQAFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A2N7RVK7|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MRKALPGASFFLVSIPVMRIPDLSSLRRVAVPLAFGGNSEQQHTYFAELHRVGMVTQLLG
IIAYSLTWILMPPPYEPNLTHAVLALLGMLASLVARYRCTTLPVLTITGACAVLALTFGL
RTMADAVEHASFWVLPVGVFMTLAIASIFNGGLSYLAVVAGVWWNVGHGLYPVNAGLPDQ
PWAPLMIAVSVLFGLALNVSFSLLRLRNYHARQELTRLAYQDSLTGLNNRRMFTQRAQQM
HGAPHGGMLHFLMIDIDDFKIINDQQGHDAGDEVLVRTAAVIAAKAHGHLCGRLGGEEFG
IVYAGNREEVRAFAGALVDAVSQAFLAARFVSISVGVAELDRGKELGHSYRLADEALYLA
KRQGKNRYVIA
>A0A011NVL5|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-12|TrEMBL
MKLLQYLSLRQMLTLPYVLLVLLLAATIGALSYAAGRVAVDTLSKQLLSEMVYRIAQAAE
RHVSGSSAVLETAFPADVAAPDDIADDLANLRTRFWLATSVHRQPNNYAYYGDRNGQFFG
LWRHSASDAELRLRTRGDGPRTIYRFSGISGELRQPVRETRIFEPRERPWFKSGQNAPLH
TWTAVYIDFRTEELVATRARRVNNAHGDFQGVVATDLSLQHVNDFLRSLKLSANGIAYVV
ETDGNLVGTSRGPHLRQDASGNNVRLNARDSDDPLIVATHRAIERLVRDAGDDMQPHTAV
FEAADGQQVEAAFARIRDTAGLDWIIVTAVPRADFLGEVTRNFERTVVVSLCASLLTIAI
GFMVLSVVAHDLKQLALAARRVGDGDLNAAFDVARSDEIGDLAKSFRLMQTKLLSDRLTG
LANREAFMRRVAERLARQLERPEPRPFAILFVDLNDFKHINDRFGHDVGDRVLQEMAQRM
RAGLRSRDLVGRYAGDEFVVMLDAVHSRDDAEGARAHLEAMLGEPLRAVDPTAAAPGTGA
SVGLAMYPEDGSDVESLVQHADADMYRRKQSHQQRPVIPASPAPP
>A0A2N7RSI1|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MFTSRNLSPALYYLFFSGEPAQQQRFFKELHFISIAILTFGLACWLVTFSLTVPRASLDH
AQAALGVTGMLVGLVLTVYARSLQAIIASGTISVLFIAFSFRVLMLGTQDPAFWVLPLGV
MITLTTAPIFSGIAYYLGVSLGVWAILGLGQFPVHAGQADQHWPVLAVTISVIIGLALNI
YFLVLRIHNYRAQRDLATMAYKDGLTGLNNRRMFTQSARALQRPGLATAYFLMIDIDDFK
KINDVHGHDVGDEVLKKIAGVIAALAGEHLCGRLGGEEFAVIYQGEKTAACAFAAQLVDA
VEAAFVPERKVSVSIGIAELVKEADLSHSYRRADESLYLAKKNGKNRYVLNAA
>A0A378Z077|diguanylate cyclase|EC 2.7.7.65|Pandoraea pulmonicola|TrEMBL
MALGLSLPALDLPTLQFVTFLLSIATGILFMLDALRRDEAESPRWWSLAFLLATFSPVLY
LLAARSTRLAVLYPLGNAVATLAFAMVWSGARRFYARSVQWVAVFGGPAVLLWGTWLFAR
PLDAWSGGVLFFSLLAFYSLMAAKEFWQASGRRLPSSIVLAVVAVLHGVFYAARAMALVW
LGPADPVFLAWFGPQVATTEMLVLIVVASFLMVSLGKERSEIALHRAATRDGLTQAFNRP
EFTRLAREQMRRHSAARSPVALLLLDLDHFKRINDTFGHPFGDTVLLLFARTATQQLRAD
DIFGRYGGEEFALFLPGVGAAEAQTIAERVREAFERAGRTVQGEAVGATVSIGIACDERS
RGELSSLVQRADRALYQAKAAGRNRCMRYTPESIMPMNEPRPETQPLRAAASG
>A0A127MNS6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MHDKAKANAPGEPAASTSGLDLADQRLLMRLIFFCTGLTLGIFSVLQCLNGNYLLAGLEA
LVCALLLWATWRLARVRDLTPWIYAYLLPTFCFLVYIIIMPQASATAFVWLYLMPVMAYL
LLGAWRGFLLSVPFVGVAALLYLRQHPLRLDAPGMIDLGNAILCGLLIMAFVHIYETRRA
QAQQLLQRLALSDALTGVASREAFQRAVLRCLEDSHGNGQRWVLVLLDVDHFKDVNDRWG
HDAGDKALQYLCARLRLHLRAGDMIGRLGGEEFALLLRNTVRFDAAPLVERLRTDLAANP
LLYRGHVIPLSATFGLAEWPVDGDDAEALYRCCDHRLYRGKAQGRNRLVCSDG
>A0A3S5XRJ3|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MQRETFVIKKNLLERLRHHPGQIVNACFLVVLIFSTILTWREVVVLEEAYISSQQNHLQN
VANTLDRQLQYSVNKLLFFRQSMGDALQTPLGFRVLQDAVQNFNTLRAKPFWQLEVEQRR
ALPINGVSDGMVTQTTLLARDDKRIGRELSAALEVGYLLRLAVSHANNKEKGVTYVSRAG
FFVSTLPAALNTSIISRYYDLVTRPWFTQQTDRGNRARAVRWFMAPFIAGQNERLITASV
PVYQDNYWYGVLAMDFTLPTMTQLLMDAVDQHKDGEYQLYDNRLNLIATSEENTERVTQF
DAQELAQIAHAVESDTQGGLRLSTQFISWERLEHFDGLVLRVHSLKEGVRGDFGSISIAL
ASLWALFTATLLISWLVIRRMVSNMYTLQNSLQWQAWHDPLTRLNNRRALFDRAKALAEE
CRQQQLPFSVIQLDLDHFKSINDRFGHQAGDKVLAHTARLIKHALRNSDVAGRVGGEEFC
VVLPGATAEQAAGVAERIRVSIHRKEILVKKSTTGRVSASLGVSSTEENASFDFEQLQSI
ADARLYLAKQQGRNQVVCRGPDKK
>A0A517X3Y6|diguanylate cyclase|EC 2.7.7.65|Gimesia aquarii|TrEMBL
MRNYYAAIQFWSYALLVVCLCPLAVLLGTYMDWPLGAAPLLLLTLPTILAAVSSPRICYW
TITVLAVCACFAEILFRTDLSEVNTTYLFSILSAAVLVGMTLLIDLYIGKLRGTISQFDA
QNDELVRRLYESQKESTSSFDNKDSVSETESDETSDTDSAEKDVNYPLLLLTLQDIGRRI
STNQSNESLIPTVISTAKASLQCEHCQVYLWDSKVRALKNPLPARSRDKLDYRPDSNQGV
AAWVIENRQIVMRNDADQDYRLKRILEEDPHMPDAIAPLTVGSELIGLLIIDKVDLDSPT
IGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLFNHATFQEKLQQLTKTADAQSTT
LSIIMSDIDHFKSFNDTFGHQAGDFVLKEVARIWKTVMPENAIVARYGGEEFIGVLIDHE
YSQAMQIAEDLRETLENCPILFEGQQLQVTASFGVTEYKHPASNTNEFVRIADEYLYKAK
ENGRNRVVGMAPNSTRKPSS
>A0A1V0LLS9|diguanylate cyclase|EC 2.7.7.65|Kosakonia radicincitans DSM 16656|TrEMBL
MEQVEHGDNALLLSEWQDLLNQTSPQVHDILTALSDEEIRHLVTAFYDYMLSHPESELFL
NTDQVSSRLSHSMFHWLRSVLGSASEDLPQLLENQRAIGIVHARIGLPLDLVARGARKLK
NELYHLLQAKATIPASLLSDTLCFSSLAMDTAIEAMTVSWSPGYQNSMQAQEQYRLLSIY
DDVNVERERQINALTSWENQFIYNIATGLPAADIITLSASEFGMWLAHKGRYLLGNQEML
ASIDELIKQADDRLVRMRASEEVLTAESRLSLLQAIRQLTGQIHRLLAAMFDALVELENG
KDPLTQLFNRRFIPTIMRREISLALNVRKPFVLAMIDIDYFKKINDSFGHNAGDITLKSV
ATVIFDHFRSSDYVFRYGGEEFMVLLVESDLSQARIMLETLRAKIAGLAIEVAPGKPISV
TVSIGLAEFDYHPDYKRLIEKADRALYAAKSHGRNRLETSRN
>A0A1C6KJG7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGLVLWPVSAEAAPDNERTVRVAFPIQKGLTELDEYGNYSGYTYEYLEEIAQYTGWDYEF
VQVPGDENESLTTLMRMLQDGEVDLMGGMLYDPALREQFDYASHDYGMVDTVLQVLYENI
PDVTINSQVQQYFRIAVLSQSSRSVKELEDYCAMNLVTPEYVNCTSVEEQKEALLSGRAD
MMLNNSVNPVEGVRTIAKFASKPFFFVTSKDKNTGLLGDLNKAIVSIEQSNPYFTASLNE
KYFTSTDNKLYLTKEEQEYIKDAGVMKVAVLKEQPPYQYWDEKQDKLSGISVDLLAYVSQ
VTGLQFELVGVDTPDLLYEEMDRDNIKLVAGMPYNYDLARERRLSMSRPYVSAQYLILMK
EDSTEASIKGKKLALTNAGSYKGEYQGNVYRYDTVSECIRAVEKGEADYTYVDAYTAQFY
INMPEFHDLKMVPQTYEARKICFGVVKSGSMELLSILNKVITTIPVVDMQGIINQNSMNK
QSYTIGDMIRMNPLEAIIVLVAGFLTVIAVLSYFLRQRARMSKKTALELRKHFRLYALVN
DYIFEYNHQTGKLLVSRPRPEKNSEPEMMDFDLKQDSDSDELKEQKQGFVDLIMQNEGIV
ETNLVCNDGQRHWLRLAVEKVYDGDALVYVLGKINMIDEEMQQRDELLSKARLDSLTHIY
NAETIRNLIIEDIHQMKEGEHGALLMIDVDHFKTVNDNYGHMSGDEVLCAVAQLLRSSFR
ADDIVGRPGGDEFMVYMKKVKDKSALCDKCGEICSKARELLVENEIGITISVGAALSCAG
DEYEDLYQITDKQLYEAKKDGRDGFKAADRMEAAGL
>A0A1C5NLG0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDNDNYKLYTKDVLNLILSNQDIDQLIPYLSKDVKAMGLYTEDVLKYNDIINHIKTYKSN
HFTFYIDQFTCTVIYQNNSVCITEGVFYLNMEEYQTRTKYFYTIVFKDHQIELLHTSIGN
TPKDLKEAPFILASCSFKLDEQLSIVDINDNLLELLLYDNKEEFLNDIDYHWINCIHKND
IFNVIKALSENVSALERHHLEYRIKRKDGSYLWIYDQGHFIFNNQKNLIVQCYLSDISSI
KNRELASSVEKEKYQMALKDNSISILEYHIQDDRMIIDILEQSKKRIYDHYLDYVSSSKS
TVFEEDKQKIVDLFTQKINGPIIYREYYRGSQEYCVKTLDATVIYNSNDEAEIILATASD
ITVNWHEQNSLKQQAQRDSLTHLYNLEAGKYIIDEYIKKNPKQQNALIVLDIDHFKEVND
TYGHLVGNELLIALAKYLLFHTNPNDIVIRMGGDEFVVFFKNVHDDLTYPCNQLMSHLNE
ISLSHHGIHFSISMGVYTFSNEQNFDNIFKIADDALYHSKRNGRNRYTIKYQK
>A0A1C6KXN7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MTVVFVCFAAFQSSLLAGIMVGSGVLKRAEQNEYRIFSEKVNGRKNNLENEMNNIWTNFD
YDEERISRYFEETDTGNLAGKEDEVLEELAPIILDSLYHTKTTGAFLILPGQDGTENSLA
SLYFRNNNPDKAGQDNENLYMLAGPWNVADKLKIATTANWSYRLELSSSNRDFYTKPYEA
ANEYGRSAWLGYWSTPFKVNPQDEDVITYSVPVFDGKGNVAAIFGVEISVNYLYRFLPAR
DLQNTDSYGYVIATGSMEKGLKLSITYGAVQRRMLEAGEMMELESVDEEEGIYRLLNHNS
SHDIYVSASRMGMYYHNTPFEGEEWYLMGLMEKPVLLHFPQKIERLLVFALLATTGIGLI
IALFVSVWFTRHAKLMELSGLPLGVFELRPHSGKVFMTSRIPSLLNLTWEQERIFTRDKI
KFTEFLKEFENLRDGGDDTFRLESEDGSKWIKITKKIMDGTVRCVVEDVTDEVLQTKALQ
VERDRDGLTGVGNRLAFEKKMECLRDNFGSGNRPGFVMCDLNNLKCVNDEFGHDKGDEYI
RAAADAIRTAFPGEAVYRIGGDEFAVYLENKDAENAVEGIARIKTAMEEYSRAQEFHAAI
ASGYAFYTPGRDLEVKDIMTRADAYMYRHKRRMKR
>A0A1C5STW4|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEHSIKAGLMITSASDYNMEICRGANEACKELGIELVIFFGGSVDPNVKFVQSSDYQKAN
VYAFANYLDLDFLVIPASSICRTDQKTREAFPKYFHIPVVTLNSQIKDYPFVIYNNKKSV
YNAVSYMIEKNHCQHIGIITGYDSGVTAKQRLAGYQEALSSHDMPFEEKYILSTPGYNIE
SGNLMNKWLQENPELDGIMCVTDDIAYYLYRELEKIGKRVGKDIMVSGFDDKPESTHMVP
PLASCHADASFIAYLGIKQGYDLYKNGSTQNQYIDAHFIPRLSVDCENHEEIEIGEFIRF
CRAEKESNEYIAQGMTQYVFGNKLVYSSNYQKTVWSFFTYLLDLSVKDCTKHRVYQQIGD
YINLIFNEDDIRYLDLERLFLCLSFLINTENYLNMEDKIKLQSFKQYIYLQMISSYNYLL
LLKEKRYTRRMRSIGQVNKGMLFESLNDDIYAIADNIPSLGIHNAQLYLFETPVMTYEFR
PFIMPKTMELIINVENGQRQPIKNTHVLLKDVLNLAKQPYKILTSIYSNENFYGFLVTDC
TYFDLETLEYLSNQIGVSLNVNAIVRELNSISNTDELTHIYNRRGLIQNIKVLYKKYKEL
SKNLYFFIGDLDNLKYINDTFGHDQGDKAIQTVCEILNDIFQTHAVIGRLGGDEFGIAFT
CKNEDFIIQIDSLIQERTQYFNKKYHLPYYVSLSYGISVFDYNSPFDLNHTIRLADTLMY
ERKKEKHIQRGKKDKEELF
>A0A1C5KZ60|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEKEQGKLIIIVSVVFAMVLLCMICTSDSVPEVKSLQECTPDAVSVLDDGRELYDFKLDQ
NDDETNSIVFYSTHQEIVVYADGKLIYQLDAVPGIWGNTPGCTWNIVRFSSNVSSLQVQF
TPCYPETAGQQKTFYIDGGYNIYRWVMRRTMPAFLISMMVILIGLYISIYWIVIRCGSRI
DGTLLYLGIFSILLGTWSANETDVATLLLANRQGCSYLAFATLMLLPMSFILFVKSFLEI
RDDRFCRIICNANLALIVLTHILNATEIYEFRRSLWMTHALIILMILYLLVVICSKIARR
QLDQRLKACVGALLLVFFATIVDVSGYYKTSNDVGVFGRISFLIFIVVLGIESARQTVAR
LKKGRRVEELEQFALNDSMTGMYNRNAYDYFVKNEKDFEGYVIVTFDLNNLKQCNDQYGH
RAGDEYIINAAHIIEDNFERYGKCYRIGGDEFCCIIPKGRYFKIERVMHKIDQDVEILNH
KNIIPVPVGIAYGYAVFTADDTDPEKVRERADEDMYRNKKAMKQS
>A0A1C5U6J3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MEEQEKKKRIELEQDMSWKMYQILTITACTANLIGTICNFCIHGTKLPTILCGICLLMIV
TIGIIGWTTKKVQIPAVLIILILVWFEFPYLYYCYGDASIVYLILGVVGLAIFFPRNVVI
ISFAVTLLEYLVIMLNSFERPSVWRNMDEAGKIGTTIGSFVIVGVSVFAMIFELLRSYEE
QRKQLLSLSEDLNFAANHDPLTRLYNRRYLVNQVNEWICKPEKSFWIVLMDVDDFKAVND
TYGHGYGDDVLREAGRLMLEEMMGKGIAARFGGEEFMLVFEQDDREQVLHSFRNIQEGLR
RYSQNTRQMDITISGGMERYEADKQLDLLFTSVDRKLYTAKNNGKNRIVE
>A0A1C5PPZ1|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLLKDVLNLAKQPYKILTSIYSNENFYGFLVTDCTYFDLETLEYLSNQIGISLNVNAIVR
ELNSISNTDELTHIYNRRGLIQNIKVLYKKYKEVSKNLYFFIGDLDNLKYINDTFGHDQG
DKAIQTVCEILNDIFQTHAVIGRLGGDEFGIAFTCKNEDFIIQIDSLIQERTQYFNKKYH
LPYYVSLSYGISVFDYNSPFDLNHTIRLADTLMYERKKEKHLQRGKKG
>A0A446C6I8|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MFRIDLRRLILWISLLSVILVLAGGLHASYLVQRDLLLRNTLEVNRAYASKLASATDTFL
TDLQRYLSYSADMLAGMESRPELMDAETRRQEQQLGHFNSSYVVSPQGKVLAVSTSSPQL
LGQNLLSDAFRDALAARRPTISEPFQTRNGRWLILYTHPIFSPDYRYLGYIAGTLYLHED
NVLDRLLGQHFYRDDSSLYVVDRNGTLIYHPDRSRLGHASPDNDALAAARRGETGEMRYA
DDQGREMLAGYAPVPSTGWSIIAQRPVDDTLQPLRALLMATASNTLPLLLISVASIWLLS
RWIARPLGELASIAKHMQNPDSADRIRKVRSWYFEAAQLKRALLMGLASLHHKIRDLRRE
TTTDTLTGLLNRRGLDEALALLQAEDEPVAIVAIDIDHFKTINDRYGHAAGDRALQALAT
LMSEGSRSGDTLARAGGEEFVMLLPGAPMAAAIAIVERLRRRMAAQHGAVPAPITISAGV
AAYPDHGATLDAVYQRADQALYYAKNHGRNAVCVADDNTQAGSRIASSA
>A0A446CBG7|diguanylate cyclase|EC 2.7.7.65|Achromobacter veterisilvae|TrEMBL
MRYPHIPWLPLLFYPALPVAAAGGLLLWREWPPALTLIVPFMPWAMALICAATCFMYQRS
QTLALTLCVLAATASWPALARDAPWALGPAMAWWSLAYAINALWSERSSMLRDTAARVGM
MALGAAAIALAGKDGVADALGVLSVQGKLAHLNVPIEGLIALLATGLALTLLFLRYGRPQ
QAGQWLGFVCLAWALPRGAQHPVELALMSAAALTALCVSLAHEGFHMAFLDELTGLPGRR
ALNERLQRMGGRVYALAMADVDHFKAFNDTHGHDVGDQVLRMVAAQLRRVPGGGHAYRFG
GEEFTLVFPGKTAAECKPHLESVRRSIEAYQMRLRDKPARPKADQLGMRRRGGRDGRNAR
PLRVTVSMGVAERSDALRGPEAVIKAADQALYRAKDGGRNQVCVYGARRRAGAA
>A0A1D8AWH8|diguanylate cyclase|EC 2.7.7.65|Lacunisphaera limnophila|TrEMBL
MNKVLLIDDNSAANDMLSRMVPRFADGPWVLEWADTYATGLKMLLSGRYVVCLLDYRLDD
GKDGLQLLREARAAGNTTPTIFLTADTDPTLDEAALQAGAMDFLVKAEFTPRMLARSVRY
ARKLGDTLEQLRLLATHDALTGLKNRREFERLMAEEWQRCARFQRSFSLVICDIDHFKRI
NDTYGHAAGDAVLQHVAGLLRGQLRTVDQLARIGGEEFAIIMLETGRDDAVQTIQRLLVL
LGESPCTLADHPEPVTVTLSAGLATMPEDADTQQGLFEAADKALYTAKRTGRNRLVTAGG
KLAVK
>A0A2X2IXZ8|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFR
RCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREI
RATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRQTGGWWIYQIWNASVN
>A0A8H8ZES0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAKELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPGD
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A3P6KG10|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIACEL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLLLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>Q6R281|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFR
RCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREI
RATVLQRTHLTVGVGSAQTKTLAKLANHAAKKWQRPGRGVVDLSNLXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAPT
KQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPY
YGNSASVKLLTPTQDSRDIINAATRSLDAIWQVGHRYQKAGVMLGDFFSQGVAQLNLFDD
NAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQG
>A0A1S8THJ3|diguanylate cyclase|EC 2.7.7.65|Clostridium puniceum|TrEMBL
MQDYEKLYNSLKTEYENYQRFSEQHRQELNQKNMKLEKSIDSMSNIIEVSKYINTFFSSD
NLMSMINDMIIGILGVTCSTIFLIEDGELRVKASNIEEMDINLTSKEFTHINNGEEFLIN
SEKPLKIDEKHKINIHSIMGCPIKLRDKFIGYIVVEHNLYKFLNIEMKIFLRSIANQIAI
AIENFLLYKELEKINQTDSLLGIYNRKYFFELLDKNTGKEEKKFAIVMIDIDDFKKVNDT
YGHQFGDKILINTANIVASCIDSKDIFARYGGEEFILYISDFTTEDSVYNKIEIIRRTLE
RSKVSFNKENKSVTASFGISFFPLNGTDINELINKADDLLYKSKKSGKNRVLSGHIFKI
>A0A3P6L2L5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNC
>A0A0S4I9Z7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MLRLNAVRPSHFVPSLVLLGAGLAAAYVKDLSVFFTSLFNVLPTLVLLMGGAYCAVYRRQ
RELFLMLTVYIAYFLLDTQTDFYRDNGRVREDAAVIFHLVCLLLPALYGLYGIWQERTHL
LQDLVARCAVLLATAAVAAGFEQSFPEALLASLAEIRWPILHGQWMSLIQLAYPVFMGML
ALLVVQYLRAPRPLHGALIVGLVGIFWMLPKTFVLPFTLNIMCSQVMLMIATAVAHEAYQ
MAFRDELTGLPGRRALNERLQRLGRSYVIAMADVDHFKRFNDTHGHDVGDQVLRLVASRL
GKVKGGGRAYRYGGEEFAVVFAGKTADQCVPHLEAVREAIAGYAMHLRDQSARPLDDNTG
RQRRTGSSGDTVTVTISVGVAERQGDNRCVEEVLKAADQALYAAKAAGRNCLMVHGLRNR
RGAVREA
>A0A839PAV3|diguanylate cyclase|EC 2.7.7.65|Methylobacterium sp. R2-1|TrEMBL
MSARVLIVDDLYPNVRLLETKLSLEYFDVVVAMNGLDALAICEKGACDVVLLDVMMPGMD
GFEVCRRLKSNPATAHLPVVIVTALDQPADRLRGLDAGADDFLTKPIDDIALMTRVRSLV
RLKAVTDELRSRALATREIGGPDPLVLAAADTGEDARILLVEDRPSAIDRIGTALSQHHQ
VTVETDPHRALVQAPDGGFDLALVSLDLEGFDGLRLCSQLRSLERTRNMALIMIGEMHEK
ARITRGLDFGVNDYLLRPVDRNELIARVRTQVRRRRFSETLRGALQASMELAITDDLTGL
HNRRYLDRHLGPVFGEATLQQTGLACLLLDIDRFKLINDTYGHEAGDEVLRAFAERVRQY
VRPMDILARYGGEEIVMVVPGAELPDARAIAERIRERIEATPFAIDGGTRDIGVTVSVGV
SVRRATDTGPADLLKRADTALYRAKSFGRNRVEAAAA
>A0A5P9Q1S8|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. YIM 10|TrEMBL
MGSFRRPTGWALWSAPRQVVVWVLAVEVAALAATAGTARLAPVDAAGLSGFALLGACLLA
HVELSRTIERKREIAAGSGPYLSTTSVWNFAAVIVLPPVLASAMVVLGYGYMWFRVWHRR
GTMKPHRWWYSACTVLLANQAAVVVLTLDPGVPATAGAVAVVVAAGAMRWFVNYALICAV
KLLSEPRTRVRDVVGGFGEQILEVGAMGLGLLAACVMDTPAVLLVGVPAVLAVLGRSAQV
ARFRKAAETDGKTQLLNATAWTDFATHALDRTSRRGGTFGVLMIDLDHFKRINDEHGHGA
GDAVLKAVAKAITAGVRSGDLVGRFGGEEFVVALPDITAVELLAVGERLRRGVAALPVAT
GHVSISIGAALAPENGLTVQDLLATADAAMYTAKHSGRNRVEPAAGLLR
>A0A1M5VWC6|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MSLSRKISTLFIVLLSFLLIVIIYSIYKLRLIENEMNEVAYIDIPLNQIMSEVEMIQLER
HILFEQFKLKEKLPKEKKTPHQEFVYQKQQLKLLLDKAVNVIAENLVNHKIRFERHEHQH
LLEVIEAYHVQSDRFEKKLAEAISHESIPSAERYQLEETSTQLESAVNSILQQLDEMTFE
AGRYAEKHEQEFLFVNTALGVCALLLGLFLTIYTIYIFRQRINKIQDGIQNMDFSIEQGY
PALGKEIFQVDGPGDELSELEQELMLLMQRLTKEITNREQVEKQLLQMVTQDKLTGAFNR
HKWDEQVLLHLDLARRGSFFSLILLDIDYFKQINDEYGHQVGDQVLQNLVHRLSTGLRKT
DMLFRLGGEEFAILLPVQEASSACMLAERLRILVCQDSDEGLPSYTVSIGVTSYQEEDTE
ESVFQRADKALYQAKSSGRNQICQI
>A0A378GGK8|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MISVITTMTFIWLLLCFASVLTLKQYAQKNLELTGATMSHTLEATLVFNDPQAANETLAT
LGKQGQFAMADVYDRNNKQFAHWEWRPEGNTDTLGLLVSQWLFPVPVTQPIMHNGNLVGE
ICLTARDSLISHFIWMSFAVLTGCILFASAIALTITRSLHHGMVDEMQNITDVVHDVRTN
RNFSRRVKEGRIEEFHRFGEDFNSLLDEMEEWQRQLQDKNAQLMRSAMHDPLTGLANRAA
FRNSIAALMNDPVAKTHSALLFLDADNFKHINDTWGHNAGDSVLTEIASRMITFGGQRYH
AYRLGGDEFAMVLSDVHSVQDVQRICTALAQQFDRSFDLHNGQRTSMSLSIGYALAWESN
SLELFLENADRNMYQVKNQRNKTTS
>A0A6I6MN07|diguanylate cyclase|EC 2.7.7.65|Terricaulis silvestris|TrEMBL
MAFGLGKLASETSQLLQELGLSRRDVSEAAIDVIERLTAERNEIAAKLALAEELADRDAL
APTLNRRAFLRELHRTMSEVERYKTPAAVLYLDLDGFKAVNDAYGHAAGDAILRHVGLLL
LDSVRESDVVGRLGGDEFGVILNRASADEARAKAQSLSDHINNSAILHAGVAHRIRASVG
VHPIALAEDPETAIARADEAMYAEKHARRVETQAFAAF
>A0A8H2NYH9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKSGGTGYSLARRLYTSRILGVALGLVCVSAAMYPLDPAPWVWGFMWFNGLVWPHLAYH
WARRARKPYHAEHRNLLIDAFLGGFWIAAMHFNPLPSATTISMMAMHNVAIGGLRFLLAG
TAAQVLGVGVGLLIFAPAFIPATSPLQLYACLPLLCLYPLALGWICFRQAHTLGRQKREL
LALSRTDSLTGLLNHGAWKDQMEVEFQRCKHQQKGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQSLRTADMAGRYGGDEFCVILPDLPLNRAAAVMDALRDRFATLGYKQNPA
LKVSLSIGLASFNPAHGDATLWLNDADHALYEAKTTGRNRVICCGNGKPHRELLDSV
>A0A5E7IVT5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRTLGLALGLLCVGAAMYPLDPAPWVWVLMLLNGILWPHVAYQ
WARRAKVPFHAEHRNILMDAFLGGFWVAAMQFNPLPSAATLSMMAMNNVAIGGLRFLLVG
TVAQVLGIGVGWLIFTPLFIAQTTPLQLYACLPLLSLYPLALGWICFRQATTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQHRGGAVALIDIDHFKTINDTYGHVAGDI
VLRQLGKMLKQNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQSPA
LKVSLSIGLAAFNPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRRELLDPV
>A0A109KI89|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAVGGKGLPLALRLYKSRLLGLTLGFVCVAFGMYPLNPPLWVWAWMLINAFVWPHLAFQ
CSLRSANTLRSERRSLLFDSFCGGFWVGAMHFNPLPSVTTLSMMSMNNVAIGGPRFLFAG
WAAQALGLGTALLLFTPGFIAVTTQAQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLDLEFQRCRQGPAGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRTTDLAGRYGGDEFCVILPDMPLNRATEVMEALRGRFNALAYAQDPT
LRVSLSIGLAPYQPSHADSISWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A174C4H3|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MGMINHKFDAETTPLYFYFALKRSYEIYAVYFLLLIICITGFGYPLHALPAAGWLIICLL
ARYYINHTFIRWNLLFYVTISAGWICYFLYYYGWETGATSFILPLMLVSMFSLYDTLFNK
IAFTVFLFIMRMALFFHCQTHPPVYVLTGIHILIIQILNTVVFFVVTSVICISFSSNLQK
AEQHLMLYNIELQQQAGTDPLTTLYNRRRMEEVLQNHIRANPNENFSIAIGDIDFFKKIN
DTYGHNCGDQVLKSLSDLFREKTLGAGHVCRWGGEEFLFFFPKMNLDNAATLMNEINIAV
SKCIISYKDITIHVTMTFGVEENDFQSSISDIVKRADDKLYYGKTHGRDTVIS
>A0A0M6ZNH8|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MLDVKTILFSLVVAELTASAVLCFLFFFWKHRDRAGHLSFGLWSIAFLLGAIGTLLISFR
GVLPDDLTIIAANFLILFATGLRRSGVAAFFCQPLRLWIAAGFAGVWLLLCSVPEIATTL
SSRVAFVQPVMMLYIAWSAIICLRWNTENLVTPKVYAFSAALETSAHFSLLTALGFGAGN
GLFEAISGHVILIALLLIMVAMVLSMFTALAMPIERSLLQFKSAAYRDCLTGLPNRRAVF
ERAEAFKSVSGANNCLTVIRFDIDEFKRVNDKHGHATGDLVLQVFGRVCEETRPVDTVAG
RLGGDEFVILSTRMEPSKARILAERIRAHFAAACSEETEGAVQVGLSAGVSSVPLDLGLD
EALEIADRAMYEAKASGRGKTVVGSAEKARVFSGAEEPQFAFYNPHPA
>A0A5E7RI47|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSVFKPWTRPTLRSVIGRGHLIVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDRAAATEALALIASTEEVADVRILNMKGQLLARWQRPESGWLSELEMQMAK
AFLEEPVSLPIIHQGQEIGSIVLTGHGGSLMRFLFSGLVGIVLCTAISAWVALYLARQQL
RRITGPLRSLASVAHAARSERAFDQRVPATAIADLDDLGNDFNALLDELESWQTHLQSEN
ETLAHKANHDSLTGLPNRAFFEGRLMRALRSANKLNERVAVLFLDSDRFKEINDSFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLTPLHKTEDAERIADKIIASMEEPIAL
PGTSEVLTSLSIGIAVYPDHGATPGTLLNAADGAMYQAKRLARGAQHTAGSEHPVADVPI
RS
>A0A3S4NVF6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MYKTIEEQVLKKTAPAELRGEFLQHQFERLQSFSLLIYIVSIFMWLLFDLIVSFLGGQGF
TWRSMVFLALFAVLTVMLAYTRKARHFDVITVLFVLGLTAGIRLIVDGLPPAVHSSWLVL
AAASMLYSISVLPLSRWAFFAVQGVIWLLLNPFLNTTTSLIELRGVLTACYSVFLCALTI
YTFLKLREVKLHNYIMSRLLLDQAYNDTLTDIPNRRSFLTLAEQRVNAVPREHDHFLAMI
DIDNFKKVNDTYGHDIGDEVLKRVATDIKTVMVKFDYARLGGEEFAIYLAGVRREEVEAL
AGQLCRVVREHPAQHPVTISIGVTRIKDDDTLSQALIKADKALYESKHTGKDRYTFHR
>A0A109KRF6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKTPTQTNAIDFDSAKLQRLGFGQPSLRPRRPATLAELRQQLNQQLQTSLEPERILGLFF
REVQRLVPLDALQYRHAASDLRLEFGHRGHHSVSYTLSHEGEHLGELVFRRNQRLLEEEL
SQLELLLVTLLYPMRNALLYRAATRSALRDPLTETGNRVAMDQTLQREIDMARRHLHPLS
LLMLDIDHFKKINDTHGHAAGDSVLRAVAGAIKRQLRNVDMVFRFGGEEFLILLSNTGRD
AAGMVGERLRQAAQAQDYWVEGTRIELTVSLGCSTLLAAESADSLLRRADNALYVAKREG
RNRLAMAG
>A0A6M5CY70|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. MUSA4|TrEMBL
METYLKNMKAEWVNLLERTDERIRLIAAEVGKNHAQQLSQEFYTVVLTDSQAAEFLSNEQ
VERQLKAALARWIEEVLACQISDVERLIEVQQTIAAVHARIGISVELVEMGFRVLKKLLY
PVINSDGYAPAEKLQVYHFTINSIDLAMEVMSRAFSFTEHNASKEDENYRIFSLLENAEE
EKERQIASLLAWEIDLVYRIVLDADLGNSLSLSQADFGLWFNHKGRHYFSGIAEAGHISR
LIQDIDEIFRNTRETSKALSNRSLRTKFLIQLRKNVSQIRTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAQAKRASTFLSVLVIDVDKFKQINDTWGHHTGDEILRKVSAAF
YDNVRSNDYVFRYGGDEFVIVLTEASEFDTTRIAERIRSRVEKTVIKSPDGQTIPLSLSI
GAAMFSGHPDYERLIQAADEALYIAKKRGRNCVELWKPAS
>A0A1C5X7K0|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MNITSLEIAQATMDMFFCLFCLIIFVSIKANNPKQKSMRMFAQLFLIATVLFFGETLAYI
FRGNLGPFNILVTRIANLMVFAMNIAMANTYVRYVSSVFVEKGAEVSGNSVKIANIFSCI
NIFIVVVNLFYPWMYYFDEANYYHRNNFWYVYTLISLVVIFIGAGMAIKYRKYLKKRSFI
SMMLFSFIPIIATVIQSFIYGFSITNLGLGIGSFVMFAAYMYDWSHNGNEHTNMINDSRF
DAVIMLIIMLLSMSVSIIACVNGIQQVTKENSEIQSRTIAQMVSTKIENEFIKPITVSQT
ISSDIDIRTYIEGKTREEAESVKDDITDRLVSIGNEFDYKMVFVVSDKTRAYYTYSGISR
YLDVENDSHDIWYKDYLDSGKRYTVNVDTDEDNNGSLSVFINYGIFDTNGDILGACGVGV
DMNDLVDILARFEEEYNIKVCLVNHDGLIQVDTDVSSIEKGYLDNSYFGNVSDDDFYYQL
SENGCYMTKYLEGFDGYIVIKDNNPVKLDVNKIILPIVLIFIASVLIMATSFVIISMREK
KAKDAYNRRYEASIKDELTGLYNRRGFEVDCEIIKKNNNLIEYVLIMMDLNGLKAANDNI
GHEAGDELIIGASKCMDNAFSGLGRTYRVGGDEFVALLRGTREEAQDAVKTFDYLTENFQ
GNLISELSVSKGVVVCSEHIELNFEEIKAMADKLMYADKDEYYRRTGKDRRRV
>A0A1C5YNN5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MEEKKRYNLGVLIGGVHTYFPKEHIKGISEAAAELDVNVCFFLGTRTKDFFEDVLGSKQK
NSYDYQFNTIHDYSLIGGLDGLIINYGTLGIQLREDDPNEFARKYNGITTVFLTEIVDVP
NCHSLICDNKGGIAMVISHLVEEHHLSRILFVAGPEHNTDAIERKEAYLETMKKYGLPVT
PGMIAQGDYSEFVDKQVERLLDSNPDAQAIVFANDEMAFAGYRVCEKRGLVVGKDIMITG
FDDCERASGMEPPLTTVQQDGELMGKMAVYDLVNRLDGKDPGKEAVSRRVPVSFVKRESC
GCVSEDASRKETPVGLGAQVHRLNKTIAGMKLELISFQRKSWFIPVLARDLNDCMDDEQA
FLKEIMEKMRELHTRCTHLFLLDEPIVYDGKRKWTCPYNLHLAASYENGRIVTKAAYERP
LVMKENGICDLMEDEERHQFMVFLLFSGEKQYGLLACDIDQEDFPFFYVISLQIGLSLHY
LEISKAEAARRLEMSRDMEEIKEKNRVLGIISEYDELTGLLNLRGFMEHTKRVCQAGNGQ
RAYMIYGDLDHLKEINDTWGHPAGNFALRSVAEILKGCLRSNDILGRVGGDEYIIMLECE
EADFGEKFRERVKMACKLFNEKSGKPFLVEISLGIAEFCPNSSTDIQQVISFADQQLYEA
KKHRKKSVSRMNNEGA
>A0A1C5TNL5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MEIDSIDMRNYRCVEKQDGAYIVAVMVEDSYYLQGSFCAILIVGIYLALASCCMVYMLSK
VMKEKDEKEKFRYKSNTDELTRCYNRRAYEEDINKLDLTKEWVYISMDLNGLKNANDSFG
HAAGDELICAAADCMKNSFSEHGKVYRVGGDEFVVIITKDILQFENILSTFDQRVAGWHG
EFVESMTVSYGYVYSSERKWKSIFDISKASDERMYESKKQYYTRIGIDRRR
>A0A6V9XLQ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Decatur|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRVHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6V9XK52|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Decatur|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHEQLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1V2QYK9|diguanylate cyclase|EC 2.7.7.65|Pectobacterium actinidiae|TrEMBL
MNELLNVDEQRDNGESDYNQVITSEWMQLIVTTSQKSFNLLRTLADQKASDFADAFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILTNNGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASIERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIMTETDDYIRSHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYENTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQAHPIYL
QNGESVTMTISAGIAVYNGHPDYECLIKAADDALYQAKANGRNRIEYAPEA
>A0A1R4B6J7|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MSLFSWSDTSIKQKIGGLFVFLLSFMLCLIVFSVYKIKQIEKEMSVVAYIDMPLSQWMRQ
VEFIELEQHLRLEQYQLEKAAKNSTESQYQQFIFEKQKVKKLLDKAISLINHSLSENKVY
LQPEAHQKVTHAIKRYAQKSDQFERLLDTIYKQDSFTDQERIDVEKIADELEDAQKQIIF
ELNQLASDDANYINQHENDLLLIGAFLVLCALLIGLGLTIYIVKVIMTRITRIKSNVDTL
NTSFEQQELPINLPNHVNSKDELATLEYDINIAISRLNHERTSHKKFEQELLFLLTQDKL
TGAYNRYKWDEQIKNQINLAENGEYRFSLIILDVDYFKQVNDNHGHQVGDQLLQCLVTQI
QRQIRKTDLLFRIGGEEFAIIAPMLTSEQAKQLANKIKQNINDLHEKGIPKFTISLGITD
YQSDDTSECIFKRADDALYKAKAQGRNCIIVA
>A0A1R4B5V7|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MTSTFDYSEVYNQALEQLKSEKIAQLPALHTLINIVSDVFHCPTALLSIYDKTQEYATSI
IVSSVGLQQEDFDKPYSFSRYVYDSASFIMVEDATKDDRFKQNAYIKKHQLKFCTGCPIT
LDGNEVIGTLCILDTSARLLSNEQQHRLKQFKDIVESLLQANLNWLQMQLACAKVEQARA
YLMRKEALSEEVAKVSGVGSWEYDIETNALYWSPQTRDIIGVDTNFKPSLDSGFAFFAPE
AQDIIRKTVDAAIESNKIWSSELPFINNQGKHMWVKTTGHGVYENGALCRLIGAFQDVSE
RKLLEQKMSESERLMQAKNDELSAIVNHIPQGVAVYDMRGLLKYWNNQHCDIYAINSSHI
RIRQSFREFLSHRYNSQETIDNPDKTMDEMYAAFDNDQSFLQRFQLQSGAIIEALYSSLP
DSGWVCTSVDITEQEKSKEKIHYAAHHDSLTGLANRASFNEYTDKLLANTQRDIDNHILM
LIDLDYFKAVNDTYGHLAGDEVLKEVANRLKNTVRDNDLVCRFGGDEFALVISGSHNLHE
TAEELAQRIVESIAQPFTFNHPAIHIGVSIGMSTIETHDTSLNNTMKQADAALYKVKERG
RNGYQLYKQVQHKQC
>A0A7G5I065|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. MT33b|TrEMBL
MTSNSKGSKGLNTLSNKQLERIIAEIDQAIEWHQSWYKQLLRSLISNVPANKHDLSDNAH
NFCEFGQWFNKLPTDTKKLHPHFSEMGTAHQKMHQGAKVLLSLNEAKSAIPVSLLDQFHA
DLDTLRDLFEAVSDEFSDVLHTRDPLTGATDRTNLLSHLRKEHERCKRHSLECAIIMIDL
DHFKRVNDEHGHAAGDKVLVALVKCIQSHLREYDQLYRYGGEEFLVCLPETELEGAKSFS
ERLRASVEELNINIGTNTPINVTGSFGIASVSVNDDIEQAIERADHAMYQAKKSGRNRVC
VT
>A0A7W6LXJ3|diguanylate cyclase|EC 2.7.7.65|Sphingobium scionense|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELDAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A1R4B4Q6|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MLALRLLFTSFFILLYGFPTLAAADSRPITTLDTIEYFQDPHTLSLDKAQARFQLGDTHT
SQRSLLSLGISDNVTWVQLSVTNHGQRVLSRRLTVGKTWIDHINVYLFQSGLLVQHWETG
DSHLPADEHLVPGLGYTISMKIPPGKHHILISASSNDPMTLPIQLLSPQEATNNDTFIHF
SSAFVYGILASLIGFNLVLYITLKQPYPLFYCLYISCFICVNITYNGYGFAWIYPNSTFL
QDYATLALMILHGISGVAFVVSYLDVSRHIPKIYKLLIFYSLCGIVVFIYYAYQFDHINT
TRFAFSYLTLSSILMIITGLLSINKIKDAKSFSFSVLCSMVGLLTTTFTIWGFIPYNYYT
YHGAVLGVLCEAIILAIIITIRLKDIESERIKNKHLSCYDPLTNLYNRRAFYQYGPPTLE
SAYDEKTSLACVMMDLDHFKIINDTYGHDTGDQVLLHIAHILTNNLREDDIIARWGGEEI
VILLPNTTMAEASILMERIRLTLENTPLRTVKGMITVTASFGLSELIRNDTLEHLLSRAD
QQLFIAKQAGRNRISQTDALLS
>A0A1U7M3R9|diguanylate cyclase|EC 2.7.7.65|Tissierella creatinophila DSM 6911|TrEMBL
MKLTQNFAILISMLIIGLVYGLTYHVIIMPLLGSRLILCIIQSIGFGLINYFAAIAIYKK
YNVLQKSNTLLQKTLQIDKLTGLFNRRSFDNHIQKLPLDDTYSIIFIDIDNFKNFNNSFG
HQIGDTVLKKVGQTIKATVRSNDSVYRYGGEEIVIILNDCDKKNAFAIAEKVRLNISELD
NSPFPVITISLGISSYPEDGTEIDKIIEASDMALLTAKKLGKNQVAMSTK
>A0A1R4B2C0|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MTVNNIYFIHIATIGSDVLFFGVAAFLLFIVKQHFNHQKRQAMLWFMTYWFASSIAYGVF
VLLCYASHTLSLILGSSVLQAMPYILTISIFKLYERVIPRQFFLISFSHVILFTLFNTLI
HLYNSNDAYLSIAVTYVSIMSVFSYAAYLIYSESLLNKIGDKILYFSIIFSLIVSVVALA
TDFILKSPLESIVMIVLAKNSIFCMQLVAIMMRFFFYEIEWHHERSIRDKLTGLYNRRYF
EDQAKLLLKHPKEYCYLAIVDVDHFKLINDKYGHLNGDIVLEKLSELLWQFFGSDLVARY
GGEEFVILLRDQEGTRVHQKLSQFREAVAKHTIYIADEKVFVTVSIGVARLHSEKELVSS
FAHADKALYEAKSQGRNQLITI
>A0A6C6ZNB9|diguanylate cyclase|EC 2.7.7.65|Salmonella heidelberg (strain SL476)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>G5Q125|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Montevideo str. S5-403|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7W2VGK9|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00325|TrEMBL
MNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVLVAQPI
TGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNLLPSTA
LLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPVLVIYP
LLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQRDATLL
IIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPATSA
IAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAKNSGRN
RTEAAA
>A0A5Y3VI28|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
NLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>S7U9P2|diguanylate cyclase|EC 2.7.7.65|Geobacillus sp. WSUCF1|TrEMBL
MSLARMMSSPPQRQMSCSFAFAGSLKKKRKIDDLVLIDELTGVYNRKYLPRVYARLRSDL
ERYGAPSCLALLDLDHFKQVNDRFGHLAGDAVLQKLAAFLRQHTRGVDTVVRLGGEEFVV
WLAKTSKSEARAVLERLQRQFAAEKVEADGALLSCTFSAGLVECDEPDRPLDYWLRLADK
ALYAAKRGGGNRIEEAAREKSGFSDEAPSQASTDRRRWAIAIVDDDELVRMMIADLVRKL
VNEQGRKADIYEFGDGLSFLESPFYQSGRQSVVILDRVMPKMDGLEVLNRLRQERKPYKV
MMLTSRQDERDIAHALNRGADEYVTKPFKWLELEARLRRLLKELEE
>A0A0H3CMX8|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56)|TrEMBL
METYLQTVRDEWIQLINETDPLVHQLTAQLASDHASGLITEFYRVVLADPHAAEFLTTEQ
VERQLQEALRRWLVDVLSCRVEQVDEQMRAQQRAADVHARIGISVDLVEMGFRILKKLLL
PLINATPHPSETKLSIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEV
EKERQTAALLTWELSLLYKVMLDSSIDNSRPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDAAFHDVRQTDDALHDRLRQVQFLRLTRTTFSQIVTLLHELFDEVARHEVGVDVL
TRLLNRRFLPTIFKREITQASRSGTPLSVLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEITEADTLRIAERIRRRVEKIKVHSPTGEPIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKAQ
>A0A395LBI8|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MQTVTSGKTQAPDIAAQVTHAMRMMGVSPIPRNYELYYEAYLGSNPQLSKELAALGSRAT
QEELDAIGAQYFSHIHRSTGIERAHTSLAAKLAELVNLLKDEQYALESYNKVLDEAYVNI
TSKSASSADILRHAIGILTEATADTMSQGKERVQTVVQKSFEMEVIRQELDEYKRIANTD
SLTRLANRRAFDDNLAAVYNNDHQKNFTGLLVADIDHFKKVNDTFGHPVGDKILATVGSV
IRANVRRDAFVARTGGEEFAIILNDSSQEECLQIADRIRTVLAGTPFRNSKTGVNYGPIT
LSVGVCMATAAEDAVDLYNKADIALYSAKNAGRNKTMLFEDGMRKESGRNWLIYRR
>A0A8B2XZ20|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. AM17-18|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGAINLTYTAINVIEAVVGALLLRKLLPWYNPLQN
LSDWIRLAMGSALVPPLVGGILVIFLVPGPEPLRDFIVWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLLTMAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFLVFL
VTVMVVSLMIAHNPEALTTQHEGPMINAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EARFRNAMEYSAIGMALVSIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGERGPLMENIHSGDMSRSDIDQDVVLNCRTGGAFDIHYCITPLSTLDGQSIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSMMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
TGRLVHSINDYHFMWEGRLHRIGASAGITLIDEHNHLASEVMSQADIACYASKNSGRGIV
TVYEPQQERDHSTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVLEEHAFRSGLAEPELLHALDRRIFSDFFRTSAARIASKGMGIALPLSAAGLASVTLV
DELLDLLDKSPMPGRLLHLVIPAGVVCDSDENLQRGLQKLRQAGCRVILSQIGRDMDIFT
HLSPNMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A4Y7RHF9|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum schinkii|TrEMBL
MMTSANRAFLLLVKKDVIVMLHGYLAYIVALLIASVISLLMALFLFIRRTKTGAVVLAYL
MLSTSVYSLGYAFELACSTLSGMLFWSKFQYLGISIIPALWIIMVIQMTGKDRWLTRPVL
IAIFIIPFTTFILHLTDSYHHLYYSSVSVNLNSPFPLLVFTKGPWYWVHVAFTNLSILCG
NIMLLDMWRRSAPSYSRQAAIILIASLAPWAGLIIYQTGRSPWDLDLTPFTFTCTGLITA
WGLFQYRLFDLIPVARDKVFDSMRDGVLVVDTSDRIVDFNPTAQLIVKKLSKKDIGRPAK
EVLADYPELLKQLSVNNNEQNNLQTSQGGVSYYYNSRVTPVMNDKNKLIGKTIVLNDITQ
QVLLHEKLSKLATLDALTNIFNRRHFLDLSNDELCHAKQSGTSISLILMDLDHFKQINDT
YGHKAGDIVITTVTAVCSNNLRVTDLFGRYGGEEFVAFLPETSSEEAFQIAERLRQNIAV
TRIELDDGSITVTASFGVASADKAGDIELDELLKNADEALYEAKEAGRNCVRRRFLN
>A0A7V7M9U6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQHQRVLVTTPHPLMRLVCLGLVTFIFTLFSLELTRFGALLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWSSINPTYTAINVVEAVVGALLLRKLLPWYNPLQN
LNDWIRLAIGSALIPPLVGGVLVHLLIPSPEPLRNFLVWVLSEAVGALALVPLGLLFKPH
YLLRHRDPKLLLETLVTMAVTLVLSWAAIVWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIAHNPEALTTQHTGAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIDGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRSGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRESLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWLQTEAIGQPV
LKVLHITFGEKGPLMENIHSGDMSRSDIEQDVVLNCRTGGVFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLVHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNNGRGVV
TVYEPQQERAHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRAYAAPVAKKGLGVALPLSAAGLASTTLI
DELLDLLDKGPLPGRLLHLVIAIDVVANPDPNVQTGLQKLRHVGCRVVLSQAGRNMDLFS
HLGANVADYLMLDAEVVTNVHGNLMDEMMVTIIQGHAQRLGMRTIAGPCNQPIMMDTLSG
IGVDFIFGDTIGEPQPLDLLLNTSYFAIN
>I6EU12|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>I6E6D1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMR
ALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAAL
LPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQS
GSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLR
NIFYTHDRPLLWRFLNVTLTDTDSGREVAKFSVPLQKPSQ
>A0A377LYH5|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MLTMLRSSDVLARLGGDEFGLLLPDCNIESARYIAGRLVHTINDYHFMWEGRLHRIGASA
GITLIDENNHQASEVMSQADIACYASKNNGRGVVTVYEPQQERAHSARSMMSLDEQWHMI
KDNHLMMIARSVASPRIPESCNFWLISLRLWTSQGEVLEEHAFRSGLAEPELLHALDRRI
FSEFFRAYAAPVAKKGLGVALPLSAAV
>A0A7H8UGB1|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGSLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWDAINLTYTAINIIEACIGAVLLRKLLPWYNPLQN
LNDWIRLAVGSALVPPLVGGVLVHFLVPGPEPLRNFLFWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVITLALSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMVRNPPSMTPSNMMVTFNAPWLPFLMMLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLGQLINGEINSYSLEKRYYTRNGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPSHIKPTWQLWHDAIV
PEDRTNAERVLRESLQARVPFKLEFRIRVKGGIRHIRSLANRVLNKHGQVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNVTFMNPVAEKMSGWTQNDALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLDGHNIG
SVLVIQDVTESRKMLRQLSYSASHDALTRLANRVSFENHLKRLLQTVHETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDNNRLAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSMRSMMSLDEQWHTIKDNHLLMIARSVASPRVPESSSFWLLSMRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSDFFRTHAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLIARGPLPARLLHLMISVDVLSNADENVQQGLQKLRHAGCRVVLTRVGRDINVFS
RLSASTADYLLLDTDVVTNVHGNLMDEMMVTIVQGHAQRLGLKTIAGPCNQSIMMDTLSV
IGIDYIFGDTIGEAQLLDLLLNTSYFAIN
>A0A381EWN8|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MAHHDALTGLPNRSLLSDRLHVALAQAQRRDTRLALLFMDLDSFKLINDSLGHKAGDKVL
WQAAQRLSGIVRQSDTLARIGGDEFVLLISDLDDKAEDVARTVANKCLEAFNVPFLVSGT
ACQLGISIGIAIGDGYSSADSLLQAADQAMYRVKKTGSSGSATICL
>A0A381EZR8|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MRWLEREPIIFGRQEAELARETVEMLRQSVRHAFIVIPFFAYLMYPQVPWQRSLAWTLCF
LAEELWLGRLCARFGHAPLPVLQTWGRYLEVRGILLASSMAWPTIMWLMLPDQEGPYRMV
VLLWLVGAFALACLLLAPCRDLLRGYIIGYWAYPLYRLYYEGGGMYLAILIGSVIYMLVQ
WEFLQSFHRQLQDTANLSERNESMLASVQALHRESMGKKALLEKRQQVLQSALQQMKKLA
ESDALTGCYNQRALRERLDRCAEASLASGRPWSLAMLDLDHFKQVNDTFGHLAGDRLLCQ
TARLIQSRLPEGCILARYGGEEFAVLAPDRDGLELLSLMEEVRTLLSTSSLEGLPVGRVQ
TMSVGW
>A0A381F2S1|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSNSLLIMVSLAVASIGLITWQHSVRSDLMRARRRWLQASLLLAAGMLVEGYVEPGKGEM
LRLALGSGMSNAGIALQLTIIARVTGLKPPNWLWLAFGAVSALDKLLPYPPLMLALESAE
IPILYLAAAWLYQRAERLVSRNRFSPTALLFLLGALLFIWRDASDFYLRLQATPIQPDNL
DQLHQLALAFAAAAQVCGAVGFLNIVLQRQHNRLEDAANLDPLTGAGNRRALQYWLRTLE
ASVERVCVVMLDIDHFKSVNDRYGHPAGDAVLQALAMVLRSGIRDNDMLIRYGGEEFCLL
MPDADIDDAVQAAERLLQAFRQLAPLPGHPELRCTFSAGAHEWDCRRQDFADAQQKADQA
LYQAKQDGRDRVRRH
>A0A396RT01|diguanylate cyclase|EC 2.7.7.65|Pseudomonas jilinensis|TrEMBL
MPRLSMEQLSVEWAALNQKFPAQVRQFVLEFCCEHSLDLAQHFYSEMLQDPAASLFLSHD
QVHSRLQGSMQRWIAGLFAASDDEALQRLIAEQKKIGEVHARIDVPVHLVLRGARCLKDR
FVELLDQAGTQAEGQRLAAARLLSDTIDLAMEIMSHAYSVSHDRNSRTEEAYRLFAMTQN
IASEKERQRAALLDWENQLMFDQAVGLQAAQLPRIHASEFGLWFRHKGIHAFEGTAEATT
IMEIMEQVDDTLLPLFDEQPEQKVQRLRELRDRVKVIRFSLDHLFEQNNALEAGRDVLTR
LLNRKFLSVVLTKQVSYARDKGTPFAVLAVDIDHFKTINDSHGHEAGDRVLQQFATLLIN
SSRAGDYLFRLGGEEFLMLLVDTGADGARRAAEKLRQNVAREVFRLPQEQSLNVTVSIGV
AGFDGHPDYQQLMRRADEALYQAKHSGRNRVVVAQ
>A0A0U5BFR0|diguanylate cyclase|EC 2.7.7.65|Aneurinibacillus soli|TrEMBL
MIQSVLSNIAVILIMHACLNFMVTFLKDKVSKGVFYSLVVFIISFTSISMFYLPIEYKGY
RLDLRVIPLGFAALFIGWREVLPALAIVCMWRWGMGGAGAVPGIVFGLLLPTIFVLLFYI
GNTTKVQLFKVWALFSVMWLISDLPIIIWIPNGWEVFMMIAPFRYISLMSSAVILYLFVI
WSTRQIELQHKLKFFAEHDPLTEMYNLRKFFDLLEVEYKKKKTVNYLALVDLDYFKKIND
TYGHLTGDRVLQKMAKVFLQTCKTINSEGQRAFVARYGGEEFILYVSCTSVEYLESCLEH
IREAVAAAEFWAEDGSRIPSVTLSIGCAELTSIENVQQTLLYADQSLYEVKNSGRNGVKI
YKEE
>A0A3S4HM14|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MSNSLLIMVSLAVASIGLITWQHSVRSDLMRARRRWLQASLLLAAGMLVEGYVEPGKGEM
LRLALGSGMSNAGIALQLTIIARVTGLKPPNWLWLAFGAVSALDKLLPYPTLMHALESAE
IPILYLAAAWLYQRAERLVSRNRFSPTALLFLLGALLFIWRDASDFYLRLQATPIQPDNL
DQLHQLALAFAAAAQVCGAVGFLNIVLQRQHNRLEDAANLDPLTGAGNRRALQYWLRTLE
ASVERVCVVMLDIDHFKSVNDRYGHPAGDAVLQALAMVLRSGIRDNDMLIRYGGEEFCLL
MPDADIDDAVQAAERLLQAFRQLAPLPGHPELRCTFSAGAHEWDCRRQDFADAQQKADQA
LYQAKQDGRDRVRRH
>A0A0U5AZW5|diguanylate cyclase|EC 2.7.7.65|Aneurinibacillus soli|TrEMBL
MNNDLVHVEYKQVIADSFYARYLMDVFRNSQSFLSASSFPADAGWLFVVDGKGRTIAGRR
IGDTLCSLEKSYPVLATEPYIEELDGNCTICVPVLEDVWFPGYVGVIFSNAVDSKCGLSF
VQGFASVFRLVQEQYVAKSISACLKAVNETLHLDCIMETISERLAASLDQTECLVMVYDA
EQDISPHWIASKKRIRRRDYHMMRDIHTVYKQITSLFTSKRTQLTNENSNILTLLDNPDV
FEESYVISPLRHGDQIIGVIAVLRSKGQSISEREKLFVERFAKDLSLAVYNAMMYMRLER
DEQKRTLLFEVTKKIHSSINVEDVLDAVIKNTKKLYPKMQVDLWLSHDTFSKLPVKQFTF
DVNDISSRAFMEGRTMLVQSQGERALTLASPLRGKQGIYGVIELYTNESLSLHPREIEYI
TMLADTAGSAFENAQLYQQSQNLIKELLLIDEMTSQLNKNIRLDDLLASIIHKLTETFRA
EHCCILSRVDDSPRFIIQASTDKQEDNVFEIKEDCRLRDLLLNKESLLLADASGMDEIVS
LFSCRSLMAVPFIDNNKVEGAIVLTDSEPNRYTFDDFKRLQMLARHVKVAVTNASLHAEV
ERMVITDNLTGLYSRKYLYDIIRQSYQRDACGALILIDVDHFKNVNDTYGHQTGDEILIQ
VADVLNNSIRLSDIAARWGGEEMAIYLPRVGGDIARQVAGRLRVNVMNETTPKVTISGGI
AVWSRDSSELDVEILFQKADEALYRAKRSGRNRMCEADEMNK
>A0A564V0C8|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDVSVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A419B0B9|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MNELLNVNEQRDNGESDYNQVITSEWMQLIATTSQKSFNLLRTLADQKASDFADAFYSYM
LQDQDASLFLSSQQVHDRLHGSMSKWIVDILTNTGDRLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKTLCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIITETDDYIRGHSTTALLTQQDYAPLLKTVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSNTSLSIAMIDIDHFKTVNDTYGHAA
GDSILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIYL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKASGRNRIEYAPEE
>A0A1Y0N599|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MSPTAPIPFEAPHNTLLHQAQAALQRGDVDYSQALSKSALLHAQRRSDAGGQARALLYLS
QGDRQMSRMRRARETAQRAVYLFQTEGDATGEAEALTTLSHVLSVMGHSGEGVEAALLAI
KLCENRDPIGEALARNYLGVAYAHSQSFDKAAEALHQSIRLLEAEALWPESCLPRFHLRA
AELQRCFFDRYYHGAFVTLEPLQATRDLPELATSSASNVRALQCPYRKTRALLELSFGFE
SCWSGDLEDAARRADAVCASVEKGTDQPSVRLMEIWLRAEIAWAQQDWLNAESHAQRLQQ
LALRAENEHLRATSHLLLAQLYSAQAKDALAQTQLRLLKMQETHLRNESLHSREERVEWQ
LRARAVHAASRQLEQEARRLEQLALQDALTGLYNRRHLEQMVPGILARARERGLTPAMAF
VDVDHFKRVNDRFSHSVGDEVLKALAHILSSFVREGDVPVRLGGDEFVVVFTHVDAHSAQ
ALVARIHKAVNEFDWGHLRDGLEVTASCGLALAQPQDTLESWLHRCDLSMYVEKDSRHQD
LA
>A0A1Y0NCF4|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MTLLTCSHTLASRALAMVVLCWVALFSQHVGAQTTYTLDDNVGSFRLQDSLAFLVDPDGK
SNIDEILKRDRNRFSPASTARSLPLREGNSVWVRLSLARDAHSTAKWTLAIPLPYLDYAA
LYQPDGQGAWTRQVAGDTLPVDSWSRPALYADFKLDVPVEGAYDVYLELRNFKPTLMPLM
IATESKRNSQRELEHLLLGGLFGALIMLVGVCAIHYLQSRSADDGWYTLYAAGMAVVVSC
MTGLSGLWLWPQSPAWSNYTHFSMPILGLGATLIFVRHITSLDAGFPRLSQAVYGVAGFG
IPIALLGVAIDRSVADVFNAVYLATCPLLLLVATIQTWRRGHAVGRWLTIAYTPNAVVTV
YIGLQMLQLLPAWWQSRYLMVAAVALSVPLLQQALHLRARERREVQERADALPTQDALTG
LLTRPLFDTQVELAIKRSRQNREPSAIVMVEVVNYSYLRESYGDAIAEQCLLRAAVKLHR
VLRDVDPAGRVDTARFGLVLDGVASRQELTERMVRLVASGLIPLPGLRPEVTLQFHISCA
LLTEVVADKRTVLQELQDVLHGMSPRTRRPIRFLEPAPTMPAALPSKEDGNSDRAPLTPH
SKP
>A0A5K1I4H4|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MSADQWAEGVDRLLAEIGPVTGASRVWIFQLLEVQSDAVVQDYVFEWASSERYRQLNQNR
FRFFSAAVEDPVYRRLVEERQAGLSHDFCIPVMPEGPFRRDLAGQSIQSMATVPIFVNGH
WWGTLGIDDCERPVSWRGPGLDLLEAAGQLIAAALYRYQLNHRSRQIELFHKVANCGVWE
ISLRNGRVWCSQALKTVLGYPETYPRVPLRRLLARLHSEDRAALRACLRDLWRAAESAQF
RLDARLRLADRSWLWHEIIGEIQCNESGRPVAIAGLVLDISRRKQDEEQALAASQLDALT
GALNRRGMDEHLETIGPVTGLRHLILLDIDHFKEINDTHGHLVGDALLRMMVGRLRHELR
PDDGLVRLGGEEFAVLVGGLGDDQAMALAERLRRRIAAEPFLVEMSQDEPPLKVAMSISL
GVARQGDDVSQAPNQLMAEADQALYAAKHGGRNCALFYGEAAERRAVNLDTD
>A0A1V5E913|diguanylate cyclase|EC 2.7.7.65|Syntrophaceae bacterium PtaU1.Bin231|TrEMBL
MQRPGVEGGYGDGVEAPAQRRELRLVGDEVLKMVAQTLLSNMRSFDFVFRWGGEEFIVII
ANVDRQKLKNSAERLRVMAQNAAYKNGKDEIRVTVSIGGTMALPPDSIQSVLARIDEFMY
MCKERGRNLCIVDGSVCHPE
>A0A5K1I8L2|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MPSNDLGPVGEKPQPDWILELTEQLPGVIFQLHRAPDGRMYFPYLAGSGIQKLGIDRLDL
AQSALPALERLSEDGYPRLMAAIERSARCQSPITTKFQLRLADDRMSWIALRAQPRKIDT
GTLWYGMMIDISEQMAEEQRLRRLSDTDDLTGLANRRKLMQRLDEEISLSNRHAFPLSLM
MLDIDHFKTINDTWGHLQGDQVLKDLATLCQEILREEDLVARLGGEEFALLLPLTPELHC
RKLAERLRERVAIHDFGIGPKRITVSIGIAEHRIGDSQETLIHRADENLYAAKHSGRNQV
MVGV
>A0A737DLV7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>R4Z502|diguanylate cyclase|EC 2.7.7.65|Candidatus Microthrix parvicella RN1|TrEMBL
MVHKPNSMTRARTEASTPGATFHAEPAVWFVPLPNADPDEVRPPARPTAPGGAGWPLESS
PPTNPGDAWHLPLAIRIAGPMLVVVVLAALAAFSAGSRNEHTGQMARHLSLTQGQYQAVS
DAEVSVALARSAAVQGLTSGNEADLAETAKQVTGQSDALDKIIARTTALNIDNSLSEPVA
GLLASDRSYMDLIQRLVTQAQDDPKTAQGPRNSHLEFFQQRRSAHDQLESDLAGAMPSVT
TMLEANRARGGIDFPVIPILLLLAGVALTWRAWRPIIGQLRAVVQTLDWIAQGQFQVRTN
LVGNDDFGRLGEAVDRLAEQLGERFSRLSEDARRGTQNRVIAEALEIADSEAAMFAVVEQ
ALGLVAPALPGELLLANPISGELSEVAAGPTAGSPGCPATDQAGCFALRRGHTVVFDSSE
SMNSCPMLRGRPSGPVSAVCVPMTFNSMGLGVVHVAAPNRLPPDSRTRDQLIDLANQAAT
HIGTLRTLEVTRQQASTDGLTGLVNRRVVEMQVGQLLSQGVPFVMVLADLDRFKSINDRF
GHEVGDRALQSFAAMLVANVRDADVVARLGGEEFLIICPELSVSASMEALERLQLALAKI
VGTDDIPLFTASFGVTHSSVGDAFPDIVRIADAGLLMAKQRGRNQAVYATPALAEEVFGG
ERSTRA
>A0A8J8AWR7|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MSERERIDGGLRGLWPRRRAADAAPALAGTALAATGAPAGPRTPPASLAELFAAAGTPDR
LLTAFADGLLGLDGELADMGRRLRRSAIDEDWTGYGRGLRQLIDKYISTIVSTAPGTPED
AEATLLRDLLRRILAMALGPLLQPAPDLAEEAQALADILKHWAGEADAETYARRLKQLCH
RVSMRADEAAEQQRLILGLFDLLLENVTELLDDSSWLHGQIAIVRELISGPIDRLSVEDA
RSSLREVIYRQGLLKQSMAESKDAMKEMMVTFVDRLNGMAASTGEFHDRIEGYSQAIRGA
RSIGELNRVLDDVLAETGRAQEQALRARDRMLEARQEVEAAEQRILRLEQQLQDASGQAR
ADQLTGVLNRRGFEELYEREAARAERSGAPLCVALVDLDDFRRLNETHGHLGGDAALRHF
AELVRTVLRGSDALARFGGEEFLLLMPDTTLYEASAAVARAQQALVGRPLLHEEARIVLS
FSGGVAQRAPSETRDVLLKRADGAMYQAKKGGKNRVVAAK
>A0A7W4PRD0|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADIPSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSALHS
>A0A7W4KLG6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTALHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQQADAHIERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIFDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVE
LIYGDVIADAQPLDLLVNNSYFAIN
>Q0T2A6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGNLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>Q0SZC5|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSKRLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A1C2DC28|diguanylate cyclase|EC 2.7.7.65|Pseudomonas xanthomarina|TrEMBL
MQHIPNEQLAGEWRRLLGQFSPEAAAVLHGVAEQSNEDLAAHFYEQMLADPHAAVFLSHE
QVQNRLSLSMQRWVLTVLTSRPEDDLEAVIDLQRTIGDVHARIEIPVSLVLRGARYLKGR
LRRLVERQAAEAVTRRDAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFAVSQNQ
GAEKERQRAALLDWENQLMFDLAVGSGYESLPRLASSEFGLWFRHKASHAFQGTPESASI
LDYIMQIDQELQTLAEAGKEQGSLSSLHRVREQTRSIRFLLDSLFEQANELEAGRDVLTR
LLNRKFLPVVMTKEMLYSRQAGGSFGVLIVDVDHFKRINDAHGHDGGDQVLQQVATALSN
NTRGGDYAFRLGGEEFLLVLVDIDAQKITQAAEKLRQRIAEDSFRLPQGEVIKVTVSIGI
AVHDGHPDYERLLRRADQALYEAKNAGRNRCVLARNG
>A0A2N7RKE6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MKSPSQTNAIDFDSAKLQRLGFGLLPPLLERPASLAQLRQQMSLQLQTSLEPQRILGLFF
REVQHLVPLDALSYVHQGSDLRLEFGARGHHSVSYSLSHEGEHLGELVFRRNQRFSEQEQ
GNLESLLSSLLFPMRNALLYRAATQSALRDPLTGTGNRIAMEQTLQREIDMSRRHLQPLS
VLMLDIDHFKRVNDSHGHSAGDDVLKAVAASIKGQLRNVDMVFRYGGEEFLILLSNTGRE
AAAMVGERLRHAAQAAEYFADGHLIDLTVSLGCSTLLPGESADSLLRRADSALYVAKREG
RNRLAMAG
>A0A399EJ96|diguanylate cyclase|EC 2.7.7.65|Meiothermus luteus|TrEMBL
MPGSCLRSAEGPFEALRLEQRLQERHRLHTLGANFVIFMDKPGVVLEPETLAWLDALPEA
AVWLDLEGRIGWYNPAAASLLSGVQLLGSSLADWLQPASALQGPRWWQGSSDGLLGLPGK
RWRWFRPSQAPYKGGWLCILHEVTQEYTQALAYASSLEVLSSLLTQEEKLEHLFQRILEA
AVKVVPGAEAGSLTLLENGAFRYVAQIGFDPELTQHSVSYQDELRWYGLGEEAWLLGKPR
LLVAPELQERSGNTATPGLEVFQKAGKIEHLKATVTVPVVLQGQVMGTLNLDAFTSTEAF
PKESLAIAQTFALQAATVLYGLLSRRYLSELALQDALTGLGNRRALEEDFVRIKAQAERL
DLPLTLIYWDMDGLKRINDHYGHAAGDQALKILATVLRSVMRKEDQAFRIGGDEFVSLHL
GLPLEEAPEVIERVRAELHVEVSAGAVRVSALMDLATALSQGDAAMYADKRRALRSTEAE
EGL
>A0A5P9CN49|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MGKKYKLQAKHTDAILDIRRQKQVLKFVAATTLIFFVPIGINNILIGEIMLGAILLTFEI
TLLLEVTAIVYKRKGFFGHTLPLILLVTSVIMAIHIFGTLATYWVFPIIISVVFLLPIKL
ALSANVVLLIGCTLAALPHQHLATTSRYAFSLLATAVIAHVIVQAIKRLQKELRYLSERD
SLTGALNRHDLQEHLENVCANYPISSVALIDIDNFKKINDQYGHDVGDKVIKQVVGVMYR
HMEESDLLFRLGGDEFLLVLPDRDQFAAKNTMIYTGQHVEQSEYPEQAKVTISSGVAQLV
NKESVEDWVKRADIALYQSKHNGRNKVSLYSGPLPSNKEKETSKFLI
>A0A399EZA8|diguanylate cyclase|EC 2.7.7.65|Meiothermus luteus|TrEMBL
MAQNTLQEDTTVPMRARVYFFMLPVAAWAALFAWSQLDLSQQNTLYEKYSLPAIALWLGL
CWLGLLAPRRVGFRAVEQGIFWGTALLMVLNVYYNLLSIGKEGLWNSSVWLAIVFVMAYF
VFEPKQAWWVSVGIFSAFLVVGLFALTPQALRGQHLDANSLVQLYVSQLCYLVLFRLLVR
SKEHALRVQLEAAHLHHLAHTDPLTGVANRRSILKSLEEALAHHQKTAEPLCLVLLDLDR
FKQINDRYGHEMGDRVLLHATQVLQQHLRPTDRLGRWGGEEFMLVLPNTSLTEAEGLCTR
LQPLLAQHDHLPPVSASFGVAAAFPEDDPKSLIARADAAMYASKQAGGNRVAIAP
>A0A645GEE2|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MFLCSYLLAKVLILYGRDNLKTLMHFDDKQQNMQEQLKLDPFTGLYNKKTFNDHLLRLME
ECRNTQKFISLAIIDIDHFKSVNDLYGHGMGDRVILYLSEMLKKIQNENTQAFRIGGDEF
SILFKGCRTEETYRTCEYLRTQMSSFPLRTADDKLVTLSCGIVCVDPENADLEMLKNAAD
SALYAAKANGRDQVVIYNDLVPSISPRPEQDGRGIGWESIGNR
>A0A495AQH7|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. R1(2018)|TrEMBL
MTKKNIDKQGRKPHGLLLLGLGLLSFVFTFYSLKLTLAGTIFAPVWFPTSVMTAAFFRNP
SRLWPLIAVICSTGSLAATAVLHSLNDINLVYTAINIVEALMSATLMRRFLSVQNPLQNL
NSWVRLALCSAVVPPVVGGLLAVWLAGPESGSAARTFFVWVLSEAIGALALLPAGLLIKP
HYFLRHREPKLLLETVATFVSTLVLSYLALRFMPWPFTFIIIFLMWSAIRLPRLEAFFIF
LVTLMVISLMMATNSISMIMPSPMVRDNAQWLPFLLILLPANVMTMVMYAFREERKHITE
SEARFRNAMEYSAIGMALVSIEGHWIQVNKSLSNFLGYTAEQLRALTFQQITYPEDLHAD
LHHLEMLLAGDINSYSMEKRYYTSQGEVVWALLAVSVVRNTDRSPLYLIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLTSDVISWDKRMFDLYELPPHVKPTYKLWAECI
LTEDLPQTEKIVRESLRARMPFKLEYRIKVKDGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNVTFMNPVAEKLSGWPQDDAIGQH
ILAILRITFGDGGPALENIHSGDFSRMAIEQDVVLYCRNGGSYDIHYSITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENELKRLLQSAGENRQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELSSLMLSMLRTGDFLARLGGDEFGLLLPDCSIDNARY
ISERIINSINDYHFVWEGQLYRIGASAGITQINADNKVASEVVSQADIACYTSKNSGRGR
VTAFEAQQHYLQKNRSVLDTDEKRRIINENPMLMLALAVAPPRVPESASFYLLSLKFWNS
EGEVVEEHTFRSGLVESELQQALDRRVFSEFFREFAAQIAQKGFGIALALSPAGLASSSF
VDELLAMLDGSPLPARLLHLQIKGESLLADDEEVYKNLQRLRDRGCQLILTHTGRELDIF
EKISRQIFSYIIIDNELIQNVHSNLMDEMMVTIIHGHAQRLALQTLAGPADLPMVMDTLS
GIGINLIYGETISAPQPLSTLLHTSYFAIN
>A0A645BPE5|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MHDSLTGIYNRTFIEQEMYHIQQEGKGPVGIMMCDVDRLKQVNDTLGHSSGDNLLVAAAN
IIKKAVRKGDVVARIGGDEFAILLPRGDLMAAKSIYKRIQEGAGVHNSRNPLFPISMSVG
YAACSSNESVSMAELLREADLNMYQEKMLRCKN
>A0A822PKK3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MLLLLLCTPYENDFIAGYLVPVFFIIFTLGVGNLRYPFLNLTWAVSTLCLLNYNQNFLQG
VETEYSLAFILAVLISFSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAP
EQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLV
LSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQ
SCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILA
RLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTL
LQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGT
GYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQ
QALLHKLGVQYLQGYLIGRPQPLAD
>A0A7W3BR11|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00271|TrEMBL
MIRRTQEIDAILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDISGDDSHAVCQFGQWLKD
HPQHDDDECSYISDIHATHEKMHLLGKELLLAIVEERSHSWHFDSFQDALLAFTSAVMDY
KIYLLTIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKHVNDTYGHLV
GDRVLRSLASNLLSWTRYDEVAYRYGGEEFIVIIRTKTDEQACQAGLRLCHLIGQKKIPY
PEGEIGITVTAGITRVQQGETLDNGLGRADRAMYEGKQTGRNRCMFMDEKEEITLVGTND
QLTPRVRA
>A0A378SK16|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium gilvum|TrEMBL
MPASDRQWWRQTDQFEWFSNYLRERGMQQRWRWATFTFTVVLGALPLVMLASPLGPDTDL
TRGVAIVSGAAGAGASLLWLSGWPSRTQSLVYNALCSGGIAMGCLALSNPYSGLMGCTLF
AVIGGFLAYFHSVGQVAANFAVAAICATITAARLVTETGDVALTAAAAINVIALNTGVPF
GIHSLVHSLHTDLRAADRDPLTGLLNRRAFYSAVNQLLADTHAVDAAFNVTVIDLDKFKS
LNDTRGHAVGDAALVYVAEILHRHAGASAGRLGGEEFVVADVDLPVLQRRTADLIREGIA
AGPFGITASLGICSARIAWENSAAGGMSPDFLDKLIESADAAMYVSKRAGGDRVEHRRLD
GADLADA
>A0A5Y7A6N9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis str. CFSAN000515|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVFCS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0J1ISM9|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MVIKLSDAVAQKIVELIHKQSGFDVIVCDNTGTIIADSEQVRIGQKHKGSYQILTSDKDS
AVITAQEAEESKGRVKEGVSIAIEAEGAKIGTFGIAGPLEVVPPVARIAAGMIIMMLRDE
ELKDFIRNQVRVLGTSVDQAANGEFDIVFELLKNTTESITFENGNCPEIYKLIDKMSNLA
FKDTLTGTYNRRYIDQKLPVDIISTSLSEQSLSIIIADIDFFKNVNDTHGHVAGDHTLKA
VADILSGCIQRESDWISRYGGEEFLICLPGAGLKRAVEIAEHMRSSVENSEIVYGECSIK
ITASLGVCSIKPSSRAPRINAEKLIECADNKLYVAKHKGRNRVEA
>A0A1S7RJ65|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. Kerr 14|TrEMBL
MEETAYRGTDRQVEPGHTLRSPTQPETGRFSRRRSLASKITLIFLGGVIFSYSIGALVGW
YMFVAAASEQWLNQARVNSQIASATLRSIYTYVSVTADADGQVNGILTDKPIGDDDSILV
TGFNPSDVLALIGAQTKNAVWLFRYDEAASGFRQIAAAFDNATDDDEKPLATDPIFSRDA
VAARFSTGFATIGESSHYIGLLPIISTETKKPIGAVAVSIGGSDALYGAQRKLIYNSLAA
LIVVLTVTGVLVTVIARHFLKPVPALVQATLRIAREETDVATPFQERRDEIGDMATAIET
LREAVLERGRLRQIRDMAQQLEHMAHHDALTGLPNRVLLMKTLENRLEQLSASGQPFNVM
LLDLDRFKAVNDTLGHAAGDALLVAVASRISSVLGENDMVSRLGGDEFAIIQSTNGDCES
DAAMLAARVVHAVSRSFGLEGSDISIDTSIGIACAPGHGTSATQLLQHADLGLYRAKSMG
CGYFVFYEAGMDMAAQHKHALEIDMKSALENHEFELHYQPVVNLQSGRIVAYEALARWRH
SKLGLITPDRFITLAEENNFIRPLGEWVLAQACMDAMTWPKDIRLAVNLSAVQLCNDDIV
PVVDRALEKSGFPAERLELEVTETAMLERDSSARALKLLKERGVRLALDDFGTGYAGLST
LTHVAFDKIKIDREFVSGLPANPMCSAIVNTVIDMAEQIGLKVTAEGVENSEQVEALKLS
GCDEAQGYYFAEPAPLARILKNRAVIAPIAQDEFGDIGLPTQEIYCPPQKAI
>A0A3T3EK94|diguanylate cyclase|EC 2.7.7.65|Salmonella muenchen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTVMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A655UDA2|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVQNLFFFIILGTMLMLFLFEEIEWHRLRSIQDELTGAFNRRHFKEQVQQKLKQSKQKSM
VALVDIDHFKQINDSYGHDIGDSVITYVVRHLESLALTECLVARYGGEEFAIFARENDFE
RVSQALDSVRDAISVGFHVEQQPLKVSVSIGAVIFESSHEYGEVLRQADKALYQAKQQGR
NRIMLQDVSAS
>A0A655UTF4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MDHRFSTKLFLLLMIAWPLLFGSMSEAVERQTLTIANSKAWKPYSYLDEQGQPSGILIDF
WLAFGEANHVDIEFQLMDWNDSLEAVKLGKSDVQAGLIRSASRLAYLDFAEPLLTIDTQL
YVHRTLLGDKLDTLLSGAINVSLGVVKGGFEQEFMQREYPQLKLIEYANNELMMSAAKRR
ELDGFVADTQVANFYIVVSNGAKDFTPVKFLYSEELRPAVAKGNRDLLEQVEQGFAQLSS
NEKNRILSRWVHIETIYPRYLMPILASGLLLSIVIYTLQLRRTVRLRTQQLEEANQKLSY
LAKTDSLTGIANRRSFFEHLEAEQTRSGSLTLMVFDIDDFKTINDRFGHGAGDNAICFVV
GCVRQALASDTYFARIGGEEFAIVARGKNAEESQQLAERICQRVAEKKWVVNAQHSLSLT
ISLGCAFYLHPARPFSLHDADSLMYEGKRNGKNQVVFRTWS
>A0A603N195|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPLDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0I1CXW3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A1F2PZ10|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MPGLNAGLRGTGSDPHPTRELLSRWWSDRTDYTWLPRFLDTRGLTVPGRKLVAVWCFLFA
LIAVTMQLSRFGSDSALARSILAVGTISGVYAGCRWVRNESWPTWRQSVAFVVWADLWLA
VTLFFAVRTAFVGTLGCVLFIMIGFYAAIVHSPRVAVTHIGWALAVCTTLAAMAMSEPVN
DDWVVVNLYLMVAGVVFSTAWILQIVWLRLTDDARNAHRDYLTATLNRRGLQDEAQHLLR
SDRTQALIALLIDVDSFKILNDTHGHVAGDDALTAVADRLIAAAGPEAVVARIGGDEFVV
LRGVDRGDIEQVATEIHSAVSSDSDPYPVSASTGVSVYLCPETDLPDRAVNELIEHADNA
MYRAKKRGGDRIAWVQMFRR
>A0A074IW18|diguanylate cyclase|EC 2.7.7.65|Streptococcus salivarius|TrEMBL
MVLGKVSDFLIKHQRLLTYLSIFAALMLLMRLVYDDVLIDHDNPIVLAIFIGILVLWTLA
SYLNRRQHMLSHFILQSSKLINVYAVDLDYRFIAVNKNDIRLMEEIFYFTPKIGDFPMNY
LNSEDAARLKANVDRAKKGETFIFMDTIKTGDKTLYWQNMYSPIYNNRQKVIGVFCFVLD
VTEQRLHELEIQRMAYEDVLTRVHNRRYIELAFEECLTRKEEQITVIISDLDKFKEANDT
FGHATGDKILIEFGDILTKIMPESAVIARLGGDEFAVLLPGVSENQAEFLIKLVQAEMTL
KDMGITASLGAYTDSYQSHKNFVDFFAIADKKMYENKSQKGKSNV
>A0A6B1Y2F0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFEVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0M4RTK7|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum|TrEMBL
MTWSNWRISPFVTSIFFILGVLTLYWVLFNWITTWFHARHINIDDDTVNAWHGVIYMLVF
VFVMQLSVVGKADSWEFVNFHLIAVVFCSFFLNIRMPYYSLLPVVIVYMVFDQSIFYWES
WSYAVVFVLFFWSMNYLRLWVPKHRYPWLYYYGAVAFYGGILWGLIKLKYSLDWDNTLQE
YGYLMIFAGLLYAYVNMLTQDSEIKLRLAQFASHDALTETENFAAYTEHIKYLFDDSAKN
NLNLSMMMFDIDHFKHVNDTYGHLAGDRVLQEVAATVTTVLAANDEKVKLYRTGGEEFNV
LFPGYDLASTKVIVRQVFEAVNHLVVKYEDEEINVSISVGVSTLHQADGSPIDLYNRVDQ
NLYFSKRHGRMRVTVE
>A0A1N6M410|diguanylate cyclase|EC 2.7.7.65|Vibrio spartinae|TrEMBL
MENYAFSSDEPAKFVQLKILLICFLFISTSSVIGFNILFLSKINNINHENYGFIFELIVL
LLLILIFFIIQTSPLNPKNYLIINMGMILWIVSGTIDFMDELFQQPLWLSVWGEDLLRSV
GMVLCIIGLGRLVKSVKRYICDIKKLAIYDELTELPNRRFFNSVLSNYKNRILTIIILDL
DYFKRINDTYGHEKGDTVLQEFGQILADKNLPNAMSARLGGEEFAVFIDTQDLSSVENYI
SSLLESSRSIKIHKDTHLTVSAGIALKQQHESTHNAMKRADHALYRAKTNGRNRHEWSID
K
>A0A072ZFB7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MDDLTGIPEDPQEAALALLHSRAEVARLKEREQLFSALLASVNSVLWAYDWQNRRMVYVS
PAYEKIFGRSAALLLADYEEWRNSIYPDDLDYADSSLLQVLERGAVEQREYRIVRGDGEV
RWLNDKCFVSRQGEAGLPLMVVGIAEDITDKKHMESELQRLATTDVLTQSSNRRYFFDSA
EAAFKECRREGIPLAFLLLDVDDFKKINDRFGHQVGDQVLQRIAQSGSAALRRGDLFGRI
GGEEFAVLLPGCDEQTARQIGERLQREVQRLRFQEGEHSFGITVSQGLTVLQADDEGLGA
LYSRADAAMYSAKRQGKDCIVVG
>A0A031WFR5|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MSILLKKAPKLAKHIITSFYINRDINEVLKYLCENVTWIGPGEQEFLTSFNEIKNYFYAG
QDEIPSCDINNDIFETVSEDENRCMVLGRYTVRTKENAQMILEVNQRCTFEIIEDRGKLL
IKHMHISNPYGEMQLDEYFPTKIGTQSYDYLQRLLKEKTEVIEMITNNINGGLKGSNDDS
TYSFFYVNEGLPKILGYTYDEFMEMSGGSAVGAVYPPDLPKALEDCERCFAKGPTYSSEY
RIRKKDGTLMWVLDSGMKSLNSDGIVKINSIITDITQLKNIESELKLERERYRIALQNIT
DIMFEYDIENDTLIKYQRVEIDKKIELENFETKNYSKLLESGKIIHLDDIGKLLEVLHGN
LRETIEIRQVNSLTKNEWRWIRVQCSVIYDSDHNPIKTIGVLKDITEDKSKLESLINQAQ
RDPLTQLYNQRVSQNLIEEYLCSSDSKNNDALLVIDIDDFKTVNDTFGHLEGNEVLVAVS
KILLHNTHDKDIVARIGGDEFTIFIKSLTKDLIIKITNDILNDASKIKVKDNHKITLSIG
IAFTDDSTKLYKDLFSKADKALYLSKADGKNCYSTYE
>A0A6Y2K520|diguanylate cyclase|EC 2.7.7.65|Salmonella diarizonae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
NLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRATFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGLRITMPLSIGFALTWEHATAEKLQELADRNMYQAKHRRTERSLN
>A0A4S3IJB0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3T2UX95|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>Q7UAW8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEAIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A8F5AEW9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas tritici|TrEMBL
MSAAEGHGLRLASRLYKSRTLGLTLGFVCVVFGMYPLDPAWWVWAWMVINAFVWPHLAFQ
LTLRTANALRSERRHLLFDSFCGGFWVGAMHFNPLPSVTTLSMMTMNNVAIGGPRFMLAG
WVAQALGIGTSLLLFAPAFIAVTTQTQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLEIEFQRCRRGFSRGAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRATDLAGRYGGDEFCVILPDMPLNRATEVMDALRDRFNALAYAQDPT
LRASLSIGLAPYQPTHADSTSWLNDADQALYEAKSSGRNRVSSTKGSWLRSV
>A0A2Y5AUF9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A239RVU5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MQLLDSPIFELSPIAMWLEDFSEVQKQFDLWRSEGVEDIASFLLEDKSRILSCAHKIKVL
HVNPQTLKQFEAESFEDLTANLAQIFKADMSSTHLNELVALWNGETLFENTAVNYTLTGH
RLDIRLRGTVLPGHEHDLSLVLISTEDITPYANAQRLEEKSRLIAEARFQYSPTSLWVED
FSRVKARLDHLRRLGISDFKTFLDVHNDFINECLRDIMVTDVNQATLDLFAARDKDHLLK
NLHKVFQNATQQTFRHQLLELWDGNIQHNCEAVNYALDGSIRHVLLHFAVFPGFEDDWGM
VQLALTDITARKKAENYLEYLAKHDVLTKLYNRSFYSTEINRLERNNLRPVSCIFLDMNG
LKAINDNLGHDQGDSLLRRMGNTLNQLIENTQYSASRIGGDEFVVLLPAADEAALNHCIE
SLHELLMVDNQFNNHQPISVSIGTATSQPNERVEDILKRADTAMYEHKKTYYAQNDRRVS
NYNPANDQ
>A0A0D6HYG8|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MHVDLLTLYFITIGTLLASAGLTFWEHRTHPNRSRSLGILAAGFGTLAVGCICALFRADM
PAAIGAPLSNLVILSGYLLVLNSVASLSGRHYRKRSVGLLAVMALIWLAAGVPGQDVVWK
YVSAFPIALVSALTAWELLRCDSMKTLKTRNFAIAVAGIHALVYFCRTFLLPWWVAVEGP
SVQLLASNITMYEGVLYSVLLPMTLIKLIREETHAQLVRESQTDYLTRLGNRRWFFEQGA
RLIAASAGREPIAVLAFDLDQFKAINDRYGHHTGDLVLAAFATVARDALGPQVILARLGG
EEFAALLAGDDARRAHQLGAAAARRFATTIANPADGLGIAATVSIGLACFDEDAPPLADA
LARADLALYRAKSLGGNRLEEALAPERAAAD
>A0A379SMA5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREAIILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVVPLTFSALQSAVMQFEQRRARRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNSDLANELTATLELGYLARLARSSAMLTLEAMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFTEQSQRRNPQRGVRWFTSTRPYFSDERQKVTA
SLPLDHDNYWYGVLAMEIPVASLQRFLRDVAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
MLNDRERTLLAHEIEKDTEGGLRLGTRYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQSSLQWQAWHDPLTRLYNRGALFEKASRLA
QRYREFRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPDATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICDSDATQEWEKK
>A0A380A8T6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A443WNF1|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEIADLISKVDALLSAWKSSSEGSEYKNTQALLQGIHIHCQQIGSQMGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHTGHPDYNLLLRDADSALYVAKRDGRNCVKLHEGDGN
>A0A376FC10|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MSQPCFDALNVIKTPVWLVSPVSEKIIFANVSATQIMGDKTLDDLRKGIYSASAQTVLSM
YVSELKTEQEIVEIWTTNRDGQDTPLSCRLSLAHYAPWGDVIVFEGISQQILSGLKASRS
ANYRRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDDMCSKHTWEIN
TLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELEHAALRDSMTGLLNRRQFYAITDQSSLNKLPAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSREGDMVFRWGGEEFVILLPRTSLDTAMQIAESVRAAVA
RITIPGLPRFTVSIGVARHNQGESIDELFKRVDDALYRAKNDGRNKVLAA
>A0A379TCN2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MNLHHKALRHFISASVIVLTSSFLIYELIASDRAMNAYMRYIMERADSSFLYDKYQNQSI
AAHLMRTFEAPGEPVTTEKRRAFCDAFETVNGTHGVNLIRHNYPALHGTLQTAATQCTDN
IDDVFLLPAFDQAVSINRAQDDHSHGLGTLELKFRYYVDLKKHYVYFYDLINSQRFAMHR
WTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLSGTLKGIVMVDV
NQDNLKNIFYTQDRPLVWRYLNITLKDLDSGKEIIINKSKNNLFQYVDYNHDIPGGLRVS
FSLDLTYFIVSSWKALAFYLLATALLLNMVRMHFRLYRDVTRENISDAMTGLYNRKILTP
VLEQRLQRLVNTGTPVTFIAIDCDKLKLINDTLGHQEGDRIITLLAKAIKTSIRKSDYAI
RLGGDEFCIILVDYAADLAIHLPERIVRNLQIIAPDKSVHFSAGIYNMQPNDTINDAYQA
SDAQLYLNKQQKQRRS
>A0A0D6G160|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MLRIDLRRLILWISLLSIFLVLAAGLHASYLVQRDLLLHNALESNRVYAAKLAATTEYFL
GDLRRHLAYSADVLADMETHPGLMASETRRQEEQLGHFNSSFVVSAQGEVLAVSTSYPQL
RGQHMTSDAAKTALTTRRPFISEPFRASNGRWLILYTHPIFSRDYRYLGYIAGTLYLHED
NVLDRLLGQHFNRDDSLLYVLSRDGTLIYHPDRSRLGQASADKAALAAALRGETGEIRFT
DASRNAILAGYAPVPSTGWTIIAQRPVASTLLPLNDLLMATARNTLPLLVMSIVLIWLLS
RWIARPLGELAGIAKRMQDPDSAERIRKVRSWYFEASQLKRALLMGLTSIQHKIRDLRRA
STTDTLTSLLNRRGLNEAMALLQAAETPLAIVALDIDHFKNINDRYGHAAGDRALQILAA
LLTEGSRGGDTVARSGGEEFVMLMPGASLAAAVGAAERLRLKLERLGTDTGLPAPITLSA
GVACYPAHGATLDEVMQRADRALYYAKNHGRNAVCVADNHAADGARMALPR
>A0A8B3WDR5|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPVKAFAKQISATRDHRLLAESLFGYLVEVLAPKGIGVFAEPTPEGDSLPLFSCGELTSL
DKYPSTFWPWVSQFDTADGVLPMSINTCKWEHMEVLGGESFIMMLDNAPACRTYLIVQNC
NAQQINQTFDQDLDVLQLAAARWQCIRAEKNAALEIKHRDTREAQYLDEIKLRELFVENM
KLVHQVALELSNPDSLDALYKASVEAVRDRLGFDRAIFMLLDMKKRCFSGTYGTDERGKT
NSEHHTQYDLHQLEAEYIEALSDNHINLVIIEKAPLYTEGKVVGQGWNGMLILREGDKPV
GWIAMDNYIHRSPITNYQKQMLESFGSLLSQIYIRKRQEQNIRMLHSSMVELSRCDSVSE
VCKSAVSFAIQHLGIDRLAVFLTDKNCSYMQGTWGTDIKGDIVDESYYRSELVERDIVAA
ARACPNQVAFEESVPIYHDFNIVGVGWTAMTMLTTNTGEPIAFIAADNLLTRSPLTSQLR
EVIRIFASSLAEVLQRTMAQEELKKLNETLEQEVSKRTQELERANEQLDIISKLDPLTRL
GNRRMLSQVLDDLNCDDQGAFATEHEVTFGLILVDLDHFGLYNTVYGHTEGDAALRTIGK
ILNAHVHSDKETFCRIGGEEFMLLMIGTHHSETKQRAESIRKCIEEAKILHCESSTSQYL
TASVGYASITSDQHQFDFDLLYGKADKALYQAKDSGRNRIVSALKRRKVATPLI
>A0A0J2I3D2|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKLAGLHPDELRRLQSLRASGLLNSGKEERFDRLTRLARTLYDLPVASVSLVGENTLHVK
SCAGLEVDTLPRDITFCAHTILQTDPLIVNDLQQDLRFHDNPLVTEAPFIRFYAGYPVQL
PDGATVGAFCLMDHKPRAFSVHEIQILSDLAAIVEDEFKVLDAATADELTGLFNRRGFMS
LAEYALLTARRRNEPASLVFIDLDRFKLINDTWGHEQGDKALTAMADLMKATFRESDIIA
RQGGDEFIILLANTAQQAAGIAMAQLSNNVAEYNQQAGNPWQLAFSWGCVEYDPATHHSL
NEIVAVADRRMYQAKTSHGAERR
>A0A8G0YZL6|diguanylate cyclase|EC 2.7.7.65|Leptospira interrogans serovar Bataviae|TrEMBL
MDSILILDDAQENCMLMQGILRKSGYKNTFTSQSPDEVIGWLNLKNQEPPQKECSLILLD
ILLPGITGLEILKLIREKEELKDIPVIMITALKESDVLQKAFDSGAIDYVVKPFDAIELL
ARVRSALRLFEEMTRRKEREKELENLTDQLQEVNAYLVAISRTDSLTGLYNRRYFDEILS
TEWKRCWRTEASIALIMLDIDHFKLYNDTYGHQGGDQCLKQVASAIRDCARRAGDVAARY
GGEEFAIILPETTESNAVVVSRNILENIENLGIPHSASKTNSIVTVSIGMATLSPSPENS
ITELIERADKALYLAKEEGRNCLRFYPQND
>A0A484QLK9|diguanylate cyclase|EC 2.7.7.65|plant metagenome|TrEMBL
MPYQSAPTELLATTWRRAQARHEPGTHARLRDLVAEHRTTLATRFYEAMLESPSASRFLS
HQLVQTRLHAALQRWLDTVFDIAFNARYDEAVAFQRHIGEVHARIGIPSHLVMQGARALM
MDLHALLGDAPVAERAQALACAVDTIGQATEIMCHAYDTFHERNTRAEESYRLFVVSQDI
VSEKEKQRAALLDWENAFVYEIAVNGAGPSLPRLGKSEFGMWFLHKAAHAFEGSKDVENI
LAQITQVDEAVAGLAETPAQAAIPVLKTVREQCAAIRFLLEGLFAQAAHLESGRDTLTRL
LNRKYLQVVMAREINYVRQKASHLSVLSIDIDHFKGINDQYGHDGGDAVLQHLALFLTQS
VRSGDYLFRLGGEEFLIVLVDANEAQAMAIGEKLRRRAELERIALRDGQTLSVTLSIGVA
THDGHPDYQRLLSAADTALYGAKRAGRNRVLANSAL
>A0A3T5MZ13|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQEQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5P2MED7|diguanylate cyclase|EC 2.7.7.65|Citrobacter werkmanii|TrEMBL
MFPNTMNDENFFQKKVVADEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWLGIMGANL
LPSTALLMITCINLMGAGGMRVFLAGVVLMAVSCLVTLQLTDIPVAVSSSQLSVMLSLPV
LVMYPLLFAWVSYQTIIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PATSAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A3S0PCH7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MQHNTFVVKQSFLQWLHKRSNPRLVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRASPTWQIEVDK
QRTLPINGVSDAFVEKTTLLNRDDEFLDNELSAALEVGYLLRLASSSSGNEERVIYVSRA
GFFLETDTPENASDIVQRYYYLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSGSSAADVN
HFDAPELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLEEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGSLFERAKILA
KQCEQQALPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A3V8KW66|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0C7K9Y4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MNKDFSQTPRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQMQHFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEKFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A5D4NN17|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVVPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A315GRB7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:i:-|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5I7YXT8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Brandenburg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7R6U4D8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVTNA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A0K4BPQ7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSAARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYGVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A418U4D3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A4T4N5H1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISITSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEESQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A3L9A1B6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2B7M6H4|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSDQIIARVSQSLASEHSLESLVRQLLEMLEMVTDMESTYLTKVDIDARLQHILFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPVHLPDGS
FYGTLCAASSEKRPWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFDNLKTLFSLARHLKRKAMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
KLHQNGEIIGRLGGDEFLVVSLVNENADIPSLRERIQQQIRGEYHLGDIELFYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKEKTPFIAHSDRHS
>A0A2T1MJ24|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNDHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>J7R374|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVKTVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A7B7ENX8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A786CZ02|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGIIVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8H2CPI9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MTDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATMTY
SLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFISH
WLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLH
NGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATG
DRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLH
NGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>E2QMZ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQRADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A166ZDD3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3A6RRB4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFRSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGVLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A4V4USF7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGLGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMCEALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A7H9K8L1|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQLASRAIDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHDGLNTLRLPSTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A2Y8MYK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A3V9PMM2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bredeney|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0K4UFY7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPFTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLVLVGWAFVWPHLAWQLASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IIIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNNLRLSNAPQVVLRISVGVAPLNPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A4Q4K0Q8|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium elkanii|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVLTASNGTEALEICARAECDIILLDVMMPDMD
GFEVCRRLKSNPATHFIPVVIVTALDSPADRVRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAIADKGTGGRILLVDDRPSSYEKLAPILSAEHT
VDVEINPSEALFHAAEGNYDLLIVSLSLDNYDGLRLCSQARSLERTRQVPILAISDADNN
TRLMRGLEIGVNDYLLRPVDKNELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
NNRRYMESHLATLAEQASIRGKPLALMILDIDYFKAINDTYGHDAGDDVLREFAVRIRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFSVDKGGKRITVTISIGL
TTLERKGEQVTDVLKRADTALYRAKHDGRNRVVSAAA
>A0A8F9HML5|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MRIATMTNWAYGITVCLTITSGIAMLMASNAETAERQAVQQRQIFDQLTETVETESWELS
DLARAYVINKNPDVLQEYRQQARSLTTIEHRLEKLKDRGATPQELMLLREGLQIADELQD
EQQAALASIERGADSEALSLLYGKHYEQELDRVQTQIDHFRLMLEGRAASAIAQATEKSH
TWRTLSEIMVALTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPQFTQIDE
IGDMAQAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFDDVIKVAELFAP
NIAPAIPGRLYVLETNPWQLRCVAQWLSPPDEPEVFYPDNCWAVRRGLSHPPVNGEPDIA
CSHLPDACIHQSLCVPLVAQGEAIGLLSFRNVTSATAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDDALHTQINLAVQNHAPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVAVIVQRAVRDKGMAFRYGGEEFLVLLAGASEEAARACAEEIYDSVRSLTLRD
GLTEIGQVDVSIGIASFPQHTQSDSLLRAADAALYRAKEQGRSRIVSFGMLKSD
>A0A181VDW3|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MSDFILARVSQTLATEQSLETLVRQLLEMLEAVTRMESTYLTRIDINAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVARRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVALIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQPPAAQQAYVTTLRQALCGVYFLGEQRINYEGASFGV
VICDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A637BV46|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQDREKK
>A0A714QKQ6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. CT18|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A385XUF6|diguanylate cyclase|EC 2.7.7.65|Dickeya dianthicola|TrEMBL
MSSYELFTPEYDILLSARNIAAQADMPAEVYRESLIMLAEHYQRLVRETHRLITRSDRAE
RELTRLNTQLHQLAVELEYKATHDPLTDVFNRSAIIDLVDHALEQDQAALIVLDIDHFKQ
VNDAYGHPTGDAVICALIARIRDVLQGKGSIGRVGGEEFTILLDGYTLMAAVDVAEHIHA
SLNYAALEALPQQKVTASFGVSWAPPHTGFDTLYSTADTALYQAKHQGRNRVEYMPIDAV
S
>A0A174D8L4|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MDKKKRLIQLTEGILLCCVIVVMTLLCIGIIKKEVKNTKGKLTETIGWYRIQDNKKVQVD
LNQKIKADPQGKLVLYNDTIAQKYKGYLMTTKAAKYSVRIYAGDQLIYQYSDSNFHRNDQ
MKSKLSCDARIPEQGKKGTVIKIIYQNGSNGIYDLDDILVGRGDVVMGFHVQQEIVGIVM
IAIMFFLSFVALTTGIYLKHFKLNSTRFLNIAAFLALSGIWFLSDSALAQEYTSFPALTG
MISFYAFMLMSVPMVHFVKNTLKFEKYKVLDVINLLFYANALIQGILNKCLKIHMVHMLF
VTHVLLFIAVITIVVLMIEEYRRTKDSELKIIMNAFGIMAVAGVLSLCMYWKLEIPFYGT
IFEVGVLIFEQLLLTSIFVNLVEQAKTRSELEVYERLLKEDRMTGINNRTAFEEQLQDIE
DHAQDYDNAALIFMDVDGLKNTNDLYGHNAGDELIISAALCIKNVFATYGKCYRIGGDEF
CVLIFDSIENMDELLKQMDQEIIKYNRNNRYYLSITRGVSFLKDTEGKQKKISDWKYEAD
QDMYCNKKRRNINDRL
>A0A4Y6M945|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Indiana|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4U9HRQ9|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNRKFKEIDETVRSLNQSTDAHFRWLVKILRFIDSRNVDLPEISSDEAHLHCEFGHWLNT
RLLEEREDTNFLLDINKKHIRVHQACRNLISTIEQHRQANDVFNLFEESLLAFTEALTHY
KVHLLQLRTSYDALTGLPLRRILDESFASMNKELGADGLYLLLLDIDHFKKVNDNYGHLN
GDIVLRSLALNISNNIRRSESMYRYGGEEFIVVLHASNDQDAVAIAERLRRDIARLETIA
GEHLIRVTFTGGLTRIHEGESLREVLERADIALYTGKKNGRNCSQLINRQLQTQKFCD
>F6M9U6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas alkylphenolica|TrEMBL
MPQPRRFLPLACAHPRRTVILCFLAAFAISLVLAGRQYYQLLQRELQEREHNLHLQALAI
EAVVSNGKSQLQFMRNIAERLLIEAHIQPAMRRNEAIAAAMRNSQQPLWELPVPKSDAPV
RAIGDAQLANIPGLSREPQQLIEDLHLAHAMSQVLPAQFRGESNLSRILFLTTSGIVIAY
PAVRDEQLEPILRKFTSSLLMHLNRANAEDLDIAFYPPPGSNLGSMPHVLLSTPVYLNAV
MRGALIYDVPQTKLQNYLYQTTASDEQHALIDDEGSLVASSEQMFKSLPGNWLRSLPASS
IRLSIPMLFQRDHGTLKLDDGYLQFRELQSIDLMLTNYISAADLRAAVHAQIDILFLGVW
ALLGLLMALTLYIVDRLFKGQLRLNRQLREMGLVDGLTQLANRRRLQSDFGGLLQRLREN
QPLALWMLDIDRFKHINDNWGHSAGDEVIKHLATLCRALVRPQDLVVRYGGEEFCVLLPD
TSLAQATQMAEQLRAASVQSVCVPEAGTLLAGAPSLEIRLTVSIGVAELRVDGCQGLEDL
VATADRRLYAAKKAGRNQVVSSD
>A0A5U7HWQ3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFPLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKGNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A621V0G1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DCVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0W3YIK3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6Y0CN80|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWEQLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3J9Z4L3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6D1SAM3|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MKTKKKAAASSNVLRYIWGSALATICLTTILSFWLLSGSWSMWKSAHNNVIQFDIFYRVL
QVSNDLAGERAFVNELVLSPLADKERQWQALEAHRRVTDRDMQSIPRHLLSPELMVEMQH
QLAHARRLADTFRSRELGDPATAEHAIRDMVVATDFYHQALFERTAEFLLLEPSALGPIL
RAQALGELRDATGRLGSQLLIPLATQTKIPQANREGITRGIERINTAWWLLQTQGDEASY
IPHFQRQLENTRQAFETQGIGLINRLKEESDGNQPYSISAERFAIDYHASLGAFDNLLNT
YMAGVKKHYTASERRALQSLLIRSLVLALVYALTIAMIFYIRSRVLRPILRLNNIAADLI
AGKQAHVQIDDDTAEEVQELFSSLGTLGKKLREDARISRQYQRQSEEDPLTHLFNRRAFN
SRGEALLRQSSEALSAWLIMLDVDRFKSINDSWGHPMGDEVLVALAKTLNKFSRPSDVVG
RLGGEEFAVLFLAPTAQDVASYAARIQHEIRKLTFHTSGGETFKVTASFGVSQGWQCPLE
ELLSRADSELYKAKNSGRDRICGLP
>A0A5V3TTV0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMLLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDAGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A620FGW1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWVALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3V9NK77|diguanylate cyclase|EC 2.7.7.65|Salmonella gallinarum|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0W0XV80|diguanylate cyclase|EC 2.7.7.65|Legionella rubrilucens|TrEMBL
MVFPVVMIVVGIVFLISGAYLIKRVLQQTNHYRGQWLAYLAFIGAFILSYSASIFYGLLV
DPHCLNYFYGSVFLLGATYVYLSCRLMTKTIQKMEVMDDFKNRYETLRHHTKYDSLTGCH
NRETLFDILNTRFQHIKSNDGWVIVLFIDMDKFKAVNDRYGHDVGDNTLTAFGQLLRQRL
RKDDVVARYGGDEFIAVMEHISVDEAKKIAENLITVTKQSFKKGILSKLNLGCSIGITQM
NSHSASVNAVIKEADLACYAAKQRKINGSVCVYSPMLATTNNTIDLGIHQVTE
>A0A1B6VIQ1|diguanylate cyclase|EC 2.7.7.65|Gluconobacter cerinus|TrEMBL
MTTDASEVQEPSIAEQEWQGLISQTPEPVREIVAGVIDQHAVDCVQRFYDVLLNNADAAP
FLSNEIVDTRLRAALGRWLAELFSHDAPDASILVQTQQKIGAAHARIQIPIHVVMHGARL
LKRKLRVFIQAVGLDGPRYSAAIAYAEDMIDIAIEVMSLAFVQGTRKEVEVNEAFRLMSL
GKDISLERETQRAALLEWGQSFLLDICYGGDSANTLSDSAFGLWLRHKGSVLFQGASEID
VVSKAIEHVDNVLVPKLVSERPVPPQAIKALQGALEEIHYMMDQLFKTAEAVENGRDPLT
KTLSRRFLPTILGREVSLSLRRHIPFSILMVDIDHFKSVNDKLGHVVGDSVLRYVAKILV
AQCRMSDFIFRYGGEEFLVLLTETQEEQAIQIAERIRTAIEQNTALTVNEIDIHVTASFG
IATFAGHPDYRHLIEDADRALYLAKAAGRNRWYVSKGRHVVEG
>A0A5C0A2F0|diguanylate cyclase|EC 2.7.7.65|Gluconobacter thailandicus|TrEMBL
MNTDACEVQEPSIAQQEWQDLIAQTSERVREIVAGVIDQHAAACVQRFYEVLLKNADAAP
FLSNEIVDTRLRAALGRWLTELFSHDEPEASVLVQTQQKIGAAHARIQIPSHVVMHGARL
LKRKLRMFIQALGLSGSESSAAVAYAEDMIDIAIEVMSLAFVQGTRKEVEVNEAFRLMSL
GKDISLERETQRAALLEWGQAFLLDICYGGDSANTLSDSAFGLWLRHKGSVLFQGASEID
VVSKAVEHVDNVLVPKLVSERPVPPQAIKSLQGALEEIHYMMDQLFKAAEAVENGRDPLT
KTLSRRFLPTILGREVSLSLRRHISFSILMVDIDNFKSVNDKLGHVVGDSVLRYVAKILV
AQCRMSDFIFRYGGEEFLVLLTETQEEQAIQIAERIRIAIERNTALTVNGSDIRVTASFG
IATFAGHPDYRHLIEDADRALYLAKAAGRNRLHVSIGNK
>A0A853SCL3|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MFTSRSLSPAFYYLFFSGEREQQQRFFKELHFISIAILTFGLACWLVTFSLTLSRASLDH
AQAALGVTGMVVGLLLTVYAKSLQAIIASGTISVLFIAFSFRVLMLGTDDPAFWVLPLGV
MITLTTAPIFSGIAYYLGVSLCVWAILGLGQFPVHAGQADQHWPVLAVTISVIIGLALNI
YFLVLRIHNYRSQRELATMAYKDGLTGLNNRRMFTQSARTLQRTARTPAYFLMIDIDDFK
QINDVYGHDVGDEVLKKIAEVIGGLAGEHLCGRLGGEEFAVIYLGEKNAACAFAAQLVDA
VEAAFVPERKVSVSIGIAELIKEADLSHSYRRADESLYQAKKNGKNRYVLNAA
>A0A377QCA0|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MDIKTLVLALALGNLSLCAALFFFEYERKKSLSMSTWAVAKQCQAVAWCLLYFRGVLPDF
LSILLGNSLLFAGMALDAGALWQAAGRSGWRRTVLPALGLSVALFAACYLFDVAPLLRSA
GGSLIVAGFFLSGVAALCLKWREASMLRRFLVVSMGLLSLLIAARGVLAAAVPGFDAELM
QLAGFGALYLMMLTNAFGYLLLSREKLGGELARLEVLDAATGVPNRRGFYQALAPWMALA
RRPGLPTALVVLNIDHFKRVNDSYGHPVGDAVLKTIVDTCRQQLRDSDLMGRLGGAEFAI
QLPRTTLVDALMVAERIRAAVEALPVKTERAVLQLTASLGVTTIRAEDSTVSLFKRADEA
LQSAKQAGRNRVVEAQGASTLDV
>A0A517PC93|diguanylate cyclase|EC 2.7.7.65|Alienimonas californiensis|TrEMBL
MSVAAPDSSAADSAVADRSDWPAQPVEVKASAPPVDPLAALAKENELLRAVVGIGGHQRL
VKALHDIAAGEDGPGCTALLERSPGGASWLERGCGGREMSSAVLRTLPDPMKLSKRAEPL
PSPPPSLAGAWAVPLSGGGRTGLWIAPTPPTGGDEGRGRRLWELVGDALWNRFITAEALS
AARGALALRDAQVALYAAAAQEGEPQAVLTRLLGALAVACGAERAALYTAGQNGRRIAAA
GAELPRPVAAVAAEHEARLAVAVPERLAAGEDENGIVSFDQAALARVGVRSLIGRAAAVS
IGGGATGASLLIFKSDAAPLPPHADRTLAWAGGFFADVLPRCTKAAAASRLARRDGLTGL
ANRRTFDERLTTLFAGAVATQGDLALLMCDLDHFKSVNDTHGHAVGDRVLKEAAAAIQEA
LVDSRSGDVALAARYGGEELVVLLPDFGAAGAARIAERIREAIARIELPAGGPRTHVTTS
LGLALYPYDAQDAESLLQAADKALYAAKSGGRNRIVRAG
>A0A6S7A994|diguanylate cyclase|EC 2.7.7.65|Achromobacter deleyi|TrEMBL
MPTRPVRAAFPDCEPMRLVSSNDALISPQPRAEAGRPQAADPPPADAQARHADDAQAAEL
QRLREVVARYEALFQNAPVLINAFDGRGQCVLWNEACVRRFGWTRDEINSYPEPLALFYP
DPETRARVVQSVGPTPDQSFREWQPLARTGERLSVLWSNVRLPDGSVVNIGMDMTENRRN
EAALARLAKVDDLTGCWTRAEILLRLQAMLEAARQGARHTALMLDLDYFKQVNDRYGHLG
GDAALRHFCSQLQGCLREGDAVGRLGGEEFLVLLADADADVALAVCDRLRAGLRQHPASV
DGHAVVLSASGGITRFLATDASMSDVLRRADQAMYRAKRAGRDCAVVLPD
>A0A3S4J0W6|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MFAAAEFIRDRMNTLNPGDYAAHRYIIAKDASYFYWFTPADAKPFYFSDSKMAGDITDFF
LPPVGFYTRLLQKNVKSKSLSSTDFYTDKITNEKAYSVVSYIYDLSGKEISDHIVAYLVY
DHSKPELQEALTEAFEHHIPPGLNVALVHTPTQENLCLSGDCQPVAGESIRAMSAKYAFH
SSLSLHRFVRYDTQAGIAILLAPFFFILIFLGLKYWLNASDLKVYIDSLTGCFNRKILDI
VKRRDLTRSCVVLLDCNKFKAINDTWGHVAGDRALQIIANRMLSNTRTSHDLVIRTGGDE
FVILLYRAQIGDAIAIAERITGQINDYAFMVDGHVVPLSVSWGVAEVTRDLDTAIQDADN
EMYKMKQVRE
>A0A8G5M768|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDALARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A2D1QD92|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MPLLLLAGWAAPAWAARGPLPEPVLVGELSQLENDALPPRVFRLRVAALAAHRESYSPQL
QGRIARLQCWARDSERTSEYEATIAFASEQLASARKQQDRETEAGLFICRGFNQQMLGNM
TQAKADYDAALVLAEALEAPRLKSDALSYRGDMFAYQGALAQGLIDLLAAYDGYVALGLE
GMRLQVLAQIANTYRRMGIYARAHEYFEELMQAYLQRHDQSNLIDVGTQLAILYTDQGRY
EQALPLLEAGERYYRQQQREMDLAWLRVELSWCLLNLKRVDEALTKLEQAKPVLYRHEKD
TDEATLGLWQLVMGLTLDAKKEWDKALHYLARAESIFSQEQNQRFLAWIYQARARILEQQ
GQVNGALAALQQYVQIKSELDRLLNEQRSAQIRLEFDLARKELENQTLKTRQLVQAERLK
QLQERRQWQYIVVVLLLVVMGMLALYLLNRSRKLRQLAMTDELTGIHNRRQIQAKGEVCF
RQARDNGKPLCVLILDIDHFKQVNDTLGHHMGDRVLTAVASCIGAQMRHLDRVGRHGGEE
FLVLLPDTRMEEALEVAERIRHEVSRLHIEEMPEGHPVHVSIGCAECNLLDETLGDLIKR
ADEAMYRAKQAGRNQVMRAE
>A0A2D1QDB7|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MLTDEQRRLSTRFDHHLCESRRHALSKGLFWFWAVNQLALLFLLARFYVYQDAHLVVARI
LPWRYEMQLTLMTLACLLFPLCWRWLSRQPLALWRPCLCAGALLWGLAWALFGYAIALVE
LRGGFSLAFDLISLLLMTALIALYCEARLFYCFSVPPLLFLLLEALFVRVPFPIVHGLAV
GCLVILLETGRRMLNGWFVLAVSREHENLALARQLDGMAKQDPLTGLANRRHFTRVSEQI
LAEVRQQHGDFAILLLDVDFFKRFNDHYGHLQGDTCLIAVADCLREAVRQPADVVARYGG
EEFVILLPGADTLLAADIARRIAAALAARAIPHAQSEVSPNVTVSQGIALWREDESVADM
LARADEALYRVKETGRNGYLIAS
>T0R2E9|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MTYEELQAAYDKLLQENERLKRVADDAREKLDAAMDGTGLCIWQNHLPTGKLIIFNRRWG
AMLGYQPKELSAHFDVWREHLHPEDRERVLQAFFDHLSGKSPFYQVMHRMIAKDGKTTWV
LDRGRVVEWDEQGQPLRVMGTHIDITHEKEYEQQLAQLAHRDPLTGLLNRTALQRQFPQE
FRAICFIDLDNFKQVNDNLGHRAGDELLIALTQRIKACCDEGVKLGRLGGDEFVLLLPWH
SDDPRTHHLAHQCVNVISTPFELPNGEAEVGLSMGIAQIRPQDDFSTALARADQAMYRVK
RSGKRGFYVSQPSGQPLLDQDQVNERGLGHQPGA
>A0A181Y9N6|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MARHNRKLSFTSPIVIGFAGILFSFLLIAVFATTTQRNDFLEDYHHINRNFTHNMATNYT
ETLLQGNDFILTRAATFFARNDALNEAVNVNPEKGLMQLMQLQNMMQTVSSISLADTNGH
YLRAPEVLETEDSQSFDAKSRPWFIKQAEASTFSRYTSPYNDYFTHHPTITVYKPIISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSEALMD
RMTSGEGQLYDTDTNAWYYYYSFTNPDWFVIYRVDNSTLVNLTRHETDIVAWSFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDNDIAALMNDHQPFSLALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAVIFTTGHSDDALKLLESWRARVAQRSWREEGLTVTFSAGLGEW
NMEPLEQLVVRVDEALYKAKQQGKNRIVRA
>A0A157S9H2|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MGTSMKIPGYIADARTAARNRQLSLYMPVDFIDELAAAESIDEILQVVARWFRQMFDADR
VSIALPSDTAHLRLVALEDKRAIDIDTLIPIKGTMVGRVFRKAHAEICNGLASSTDRDCL
ILASSGLGSCLDAPLTSGSHCYGTLNVARRRPDAFCAQDQRKLEVLAMWIATLVRVHRQV
ERLTHISETDPLTRIMNRRAFTDRFRMRCRDWSRRKATLGFAVIDIDHFKRINDTHGHDV
GDLVLVSLGKMLSEFFREGDLVARFGGEEFCVLMQDVNEANLLAALERFRVALGAARIRH
LQGELSITASIGAVLVLKPEIGLDKIFISADAALYEAKGAGRNRVQLAAAMD
>A0A157S5Y0|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPVLTSKAWASFVRGSYPSRALALGLTFLAVVPILRQLDAPGWQWLLYAAHAFAWPYAAW
RLSAHTDQPTAANRRNLLIDHFAAGCWAAGIAFNALLSIAMLALLLMDSMIAGGWRQFLR
GIGAHLAGVVIGLLAFGIDWRPVPTPEEILACLPLLLIYPAVAGRIAYLALNELREQRED
LSQLSLHDALSGLHNRRHMDAVIQSEFQRYRRHAEPAALVLIDFDHFKRINDDLGHPVGD
KAIRQFAKRLQLSLRSSDTPGRYGGEEFVVLMPHTSARNAGLFMRRLQQSIRDEPLIDER
PVTISIGISALSPELESHGAWLKQADAMLYRAKDQGRNCVVIAGEDAPEPQLPEPPRGAS
QPLLPLERRLMVGLELGNIAAAIFDPSDRMAWANEAFRRLYCVPPKARTFADIIHHCHRL
RCGPRIETQSLRTWLSIADTQRRRQPHRSFLQPMHDGNVYRVEETLMANGWLLNLWLPHH
REGAPSEELHAVVGGVAPLVADRQQLGQALHE
>A0A1T4ZGK4|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MSPSPSLQENQRLEALYHYNILDTASEAAFDRITLLASRLLGVPISLVSLVDQDRIWFKS
RQGLDCPQVDREGSFCGFAMYNQGVYCINDTLIDPQWCDHPLVTGEFGLRFYAAAPLCTS
DGQRLGTLCVMDHHPHELSELEVQTLQSLGELVIEQLDLRLASQRLQQTEIALMQSETRF
RALVEQAADGFLLHDFNGRILDVNEFACQSLGYNRKELLSLSLQQIEVDPLPLIFFQSLV
QGQPITLQRTYRRQDQTTFPVEVRLGLIQVGEQQLIHTLARDISDRLEIEQQLKQQAERE
RLNTRLTQRIHESLELSQILNTTVTEVRQALQNERVIIFRFDSDKEGEVLTESCAQGCFS
LLGNRYKDCCIKETLSLEKTDQVKSVADIYTDNLSCCDQELLIKLKIRAYLVTPILHGQK
MWGLLVAHQCSSPRKWQVWEQELLVSLAAQLAIAIQQSELYHQLKIVNHELKYLATFDSL
TGIANRRYFDEYLQIQWYQLSQEQAPLSVILCDLDFFKPYNDTYGHLAGDQALREVAQAI
CKAMRYPTDLVARYGGEEFAVILPKTGVAEAILIAQNIQKQIEKLQIIHSGSSVGYYMTC
SLGIGMVIPSQNMNSKQLIEIADQGLYQAKAQGRNQYVVSSLSPSMSLN
>A0A7W8L580|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia youngii|TrEMBL
MDTSKPPQNVATLYPADEAQAQAHALVAEDPPRLAIDDSFARILAGAPAGECPITVLLVD
DQSVIADAVREALADEPGVDFHYCASWEDAVRCAEETRATVILQDLAMPGADGLTLVRQY
RLNAATRDIPIIALSTKEEPLVKSAAFAAGSNDYLVKLPDRIELIARIRYHSRSYLNLQQ
RDEAYRALRQLQQQLLATNLELQRRTHSDGLTGLSNRRYLDQHLADEWRRGTRDNTGLGL
LMIDVDHLKSYNDTYGHVAGDEVLKSVAHTIEACLGHSPDLAARFGGEEFAVVVPGTSAG
GLRLLAEKIRIAVEDLAITHAGSAEGVVTVSIGAAMVLPSAAEPVTSLIEAASVGLYRAK
HDGKNQVAVSG
>A0A1T4ZLV3|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MPRSHNPQFLTENRVFRVDDQSSLIKQTEAELQQQKLDFQVVNRALAVLSACTQAVIRAT
DEMTLLQTLCELITQEAAYRMAWVAYVCQDQAKSVKAMAWAGYEADYLKTLNITWADTER
GMGPTGRVIRSGHPVACQNMLHDPNFAPWREAAQQRGYQSSIVLPMLNNGEVFGTLNIYS
AEAYAFNPREVELLTQLTDSLSFGIIALRAEQSLRENEQRYRLLAENISDLVCIQDLDRR
YLYLSPSCESLLGYGYEELIGEDPYILFHPDDRDRIAEEFCAAILGKNNISITYRISQKS
GNYIWLETLTKPILDEAGQVVQIQTTSRDITERILVQERFKYEALHDALTGLPNRNLLME
RLKLGMNRIHNFEGYHFALLFLDLDRFKVINDSLGHLVGDQLLIAIARKFQSILRSTDLV
TRIGGDEFVILLDEIKDIQEAIRATEKIFKALACPLIIEEREIHVSTSIGIVFGTKDYIR
ASDILRDADIAMYRAKNQGKARYEIFDREMHAIAINRLQLENDLRRAIEQQQFLVYYQPI
IDIYNHRLIGFEALIRWQHPTRGFICPAEFIPLAEETNLILAIDSWMLSTACQQLATWNK
KFPSRQPLKISINLSAQDFRKVNLIEEIDTILKETGLEGNAITLEITESMLIEDINKTIY
VLKEIKSRNIEISIDDFGTGYSSLNYLHRFPVDHLKIDYSFVSQMQKENRNYQVVSTIID
LGHHLGLAIVAEGIETSQQMQWLRELDCEFGQGYLFAKPLSAQDIEIKFLT
>A0A174VGV7|diguanylate cyclase|EC 2.7.7.65|Turicibacter sanguinis|TrEMBL
MKNYLFIFLIAICSMINSGDDFCIEASSVFNNSDEEWLLEKSQSKFKIGYPSSITPLNYY
YFYSSLKGVINDISQEFSNLTDKNLSSYLISDIAENESLLKYGIIDLFVSGKMEAYKEFY
YSSPIHEFEYTFYVNQGNNAKNTEDLMKYKIGIVNNDDKIEKYLLSFKDIISYPNYMALY
AGLNNGEIDAIFVPRDLFQYQSLVHELREVKSTEYLSSAWYFISDEPNLISIIDRIMSKM
QTMEKHADYFFNHQNALIGKLYNLDKSTYEWLFYRQPVIKVGIYDVPPFMYYNEDEDTLS
GMLDYVLKQIHNNFGVKFEFVFGDYEELVGAYQQGVIDILPVFEMESNEKLFLEGNNYEI
YQGQINAYGLFNQVMFQEAVGTNLNTVLGSVSSEGFLRSEMNVRVEDSISKLHEGLVERK
IDYLLLDPVYLDYFEQYNLSYKGKIGKYIFSLMVRDNQNFMTLFDAIKVHDFEDDEVRLK
YEMVLSSEMYLFEMSSLKHDLYLMHQQQFLFAGGTILCTSIILVLARMRYLDKKTEHLKY
TDYATGLLNRLGYMNQMDKMMNKGEPFTFAIMDIDHFKSINDTYGHLVGDQVITYVANVL
KKCCPQNSVICRLGGDEFVICIRDHSKEVAISVVESIREDLKGYSEYFEVTVSIGISFYR
GEAVDLEKLYQQADHALYESKKNGRNQYQIFQN
>A0A174S7I5|diguanylate cyclase|EC 2.7.7.65|Turicibacter sanguinis|TrEMBL
MARYDGLTSLYNRVEALKKGEKLYRLAKHKNPMSVIMIDIDHFKLINDTYGHQIGDQVIQ
LFSNLLKTKRNRDTVIGRYGGEEFIIFLNHRNIDQACEFAEQLREELKELSFRFNQLGIK
EVTASLGVHEYRFNEDLLDDGIYAADQAMYHSKTNGRDQVTSYRRLILEKLAPSKVSEN
>A0A839EJ90|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium myrsinacearum|TrEMBL
MDDSMLLTGIIRTLGLTALVILSYSIVIRTFSKGWKKGAAVGTLFALGGILSMNDPVVIA
PGVFFDGRTALLAIAYPYGGLVGTVVAVLLMAGYRIWLGGAGLVPGLISIITVSAIGFAI
TLIPVRRLPIGITRSTLTGLLASLSLVWIILLPHDIVATIIGFPLFAVTIANVMNVVVVT
DFLEREKSRLRIMRALEHEAWVDPLTKLHNRRAFDQAALRAMNDNKSKSTHCSLVMIDID
HFKAINDRWGHSMGDVVLADVASIIRKNVRITDVVVRYGGEEIVLLLLNTPQTVANELAE
RVRSEIEHTDFSTDVENVNVTVSAGVASLDERYTSMEALLKAADKALYRAKTSGRNRVEV
A
>A0A8B6KZI3|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNAASAIFSMILPSPEVPAVTLPLVMIMVISLSVAAY
FIFISKNYVDKLNLFSIIMGILWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPAALTVIFLDDFQNIFRIIFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQPYDLASSLKAADEALYRAKKDGRNKVAFAEDKLSKIESSP
>A0A839EEP9|diguanylate cyclase|EC 2.7.7.65|Phyllobacterium myrsinacearum|TrEMBL
MYAEYFPVVSDLVHRLGLVALVSMAYGSIIRAFHGPMTRSLMVGLLFGCSAVISMLDPVI
IDDGIIVDARSILLALSAPFGGVVAVLVSTTLTIISRILIGGSGVYAGVVGILIIGSISL
IFTLVYRPKVYSWKHFVILGLTVPLYTLSIFVLPFERAMPIFQRMALPMLTLSVTGIILI
SMFLHRERLRVDRVKTLEVDAHTDPLTNLANRRLFDRVARRTFRKAASTGGEVFSLVMID
IDSFKSINDHWGHSNGDLVLIEISTIIRSLVRKADLVARYGGEEIAILMPTADAGEAMAM
AEAIRRRVNETFFDFGRTQAHVTVSAGVSTFTSQHQSLTDLIEEADVALYRAKRLGRNRI
ELASMAA
>A0A0M7B592|diguanylate cyclase|EC 2.7.7.65|Jannaschia seosinensis|TrEMBL
MTKITLDMGTVANVLPFALVFAPDGRVEHVGPTLAKIAPRAMGRPMAQTLRFTHPRIGAT
PETVLARVGRRLRLEIDGGQGVGPTAMRCLSVPLADGWGLLNLSFSGDPTQAMRRHQLTA
QDFSQVDPTVDLMFLVEAHRIVLSQFERLGERLKEALVAAEEEAITDTLTGLRNRRALDF
HLGRLVRRRVPRFGLMHLDLDRFKEVNDTLGHGAGDLVLKAVARILSEHVRSGDLVARVG
GDEFLLVFDECGDIERLKQIAARIIERLEQPIAWEGKPCRISGSVGITMSEFYDHPNLEK
MIADADDALYLSKRAGRGRCTVALPNRTLAGAP
>A0A7H4PAZ7|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MEYELPMTVAIIDIDHFKEINDSWGHMVGDRAIKHVAELLSDNIRSSDYIFRYGGEEFLL
VLVETGAAEAFTILERLRKKISQLAFSVGADNEISITASIGYAVHTGHPDYNLLLRDADS
ALYVAKRDGRNCVKLHEGDGN
>A0A173RKQ2|diguanylate cyclase|EC 2.7.7.65|Roseburia faecis|TrEMBL
MTDHSISEKIEYKYLSFINKVFLVVHIGFLLLFANLKINFMVYFNLGSILFYTLAFFMLQ
KFKIHLYVYLASIEILLHMSAATLCVGLGCNFQLCLFGVILFFFIIECILPDKKKSITPV
LILSSLYSVAIVALYVAGNRISPFYPLSLTETGILAVVIVIFVLLLIITSMLFLLRYMVH
EEEKLTKKAEYDALTGIPNRFFMMDEIQKLFIENGQKDYYLAMIDIDNFKNINDTYGHNT
GDDALKILAKTIILQAQKHGFKYCRWGGEEFLLLGKCRSGEIPKDILEELRSAISSNCVR
TSRESFRYTVTIGAGKYTSGQSAKEWLDFVDKQLYKGKRSGKNQVVCS
>A0A142JBK3|diguanylate cyclase|EC 2.7.7.65|Borrelia hermsii|TrEMBL
MQSFDNLSKDIKNFSYIIDKDFLVWPKNSLLNPINTELIEKWGLKNALKLQRTFFDETLI
RETKKLINIEYDEESIANYHILISNLEEVYETCKKNKKIYYQDVLPTIKKVMEFYKKNQQ
TFIKYMKVPKLLSDYHVVHSINTAILTVALGNEMNLNNHKTVELCTIALLHKIGFLFIPL
RISEKKEKLSDEEFQVIKKYPILGYKILSTTNFSQSICLAILTHKENLDGSGYPNKLKSE
KINIESNIIGAASAYSAILLEKTYKGALNSGASLIELIQDADRKFDKRVLKLIIKVLSQC
PLDFIVELNDNSIAKIIKINEINVNVPYIKYIIKDGKIVPPSENQNYVKSIPKTETGVKK
ILRQDEIEFILKKYGLKEM
>A0A0M7FKT3|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRYPHIPWLPLLFYPALPVIAAAGLLLWRDWPPALTLVMPFVPWVMALIGAAICLMYQRS
QTLALMLAVLAPAAAWPTLASQAPWALAPALVWWSLAYTINALWPERAGMLRDLAARVGL
MALGAAAIALAGKEGMAQLFGALAVQGALARLGLPFEALAALLLTGLTLTLLLLRYGRPQ
QAGQWLGFVCMAWALPRGTQHEIELAVMAAAALTSLSISLAHEGYHMAFRDELTGLPGRR
ALNERLQRMGRVYTLAMADVDHFKAFNDTHGHDVGDQVLRMVAAQLRRVPGGGYAYRYGG
EEFTLVFPGKTAVEAMPHLETVRRAIEAYQMRLRDKPARPKADQIGLRRRGARGGRNARP
LRVTVSIGVAERGETLRAPDAVIKAADQALYKAKDGGRNQVWAYGSRRRAGG
>A0A1L8CNQ6|diguanylate cyclase|EC 2.7.7.65|Mariprofundus micogutta|TrEMBL
MQEKVLLVDDSLFICKTVHKHLGIHVDMEVDVAHNLEEAMQLVERDGQYYFVALLDLNLP
DAPNGEIVDYISIHDIPFVVFSANESEDMKSMCELHPQMIDYVNKDSVYSINYLGTLINR
LQKNRNIEALIVDDSSMGRKRVVNKLKRTMLTIHEAATAEDALIMLKEQDGIELVMIDYN
LPGMNGFELCKMLRDMPNHKELIIIGFSGVGDERLASRFLKSGANDYIPKSCSQEELLCR
VMQNLNMQDYIRTYRDASNQDFLTGLHNRRFLMASIPRVQANAKRHKQDYAVAMLDIDHF
KQINDSLGHEAGDMVLKSLASELKLRLRESDILARTGGEEFCIVAENCNREQAAILFDDL
RSKIEKNIMVSHNDTSIRITVSIGACCDSVLDFDAMMLMADNNLYKAKRNGRNRIKIT
>A0A1V5K613|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin506|TrEMBL
MKSVTSQAIPTAAAAARVASTAALIATLVWIGLRNYLFFHALVEGFSVVVAVVTYVLASC
TYRYAKDDLLLFIGQAHVVIAVLDFLHLLSYQGMGVLVCSCANTATQLWIAGRYLWGLTF
LLLPLFIRRRLPRPAITAALIGLAALMAWAVFAGDVFPVCFTQENGLTPFKLASEAAIIA
ITATGALLLGCRRAEIDPGLYRALIFAAAATIASELCFTLYDNVYGLMNMAGHILKIVAC
NSLFQGVVLKGLRAPLDSIFAELRASAVRDSLTGLYNRHGFQQAAIKEMNTASQTGGSIG
ALLADLDKFKRVNDTFGHQAGDEVLKTFAAILGGSVKPSDTVARLGGDEFAVLLPGAGLD
EARAVAASIRDATRSWARSSSTASTLDVSIGVALWLPHMQADIDTLMREADRAMYDEKAS
K
>A0A8I0FM80|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. C1|TrEMBL
MFLNTMNDESFYQKKVVPNEAVLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLAGKADDPMHSEFTNLKADAILTGMWIGLMGVNL
LPSTALLMIICINLMGAGGIRLFIAGLVLTIVSCLVTLQLTDIPVVFSSTQLSVMLSLPV
LVLYPLLFAWVSYKTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PASSAIAAMSRVHERLSLLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A398Q4M8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQQRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A2T0BFH6|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MIVLLQTQINIVLSILLSILLIHAYFNINRKKVTNKLIICIMGLVCFSLLLETVSILLNN
EDLKQFVVLHKLVNIIGFMMAPVILFIGSIFNKEWINRYQKEKLVVNKILLIPLIINGVA
ALISYNKNGVFHVTSQNLYERGPLFFITPCVTYIFFSYNLYIIYKHREKLTYSEFCTLSL
LYIVPAIFTSIQLRYSIYLTAWNSAAIIIVISYIFILNDQAYRDTLTGLQNRLAYDHYSQ
NISQKKLKKLNIVYIDIDDFKAINDRYGHCEGDEAIKVFAYLLRESFQLRQKKLIRLGGD
EFLIIIENQPTENVTAYIESLVQNFEDYNNRGEKPYRLSFSYGRSCYTKPVKNICQLLEC
ADKSMYEQKQNKKSKI
>A0A8E2P123|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQEGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A823B017|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEALNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFDLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCSNVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A823B8K0|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSINILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A8E2NZD4|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQSTRISMGLFFKYFLSLTKIDPDQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSLFI
FSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTAIWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSELFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>A0A7G6KF16|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPCFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A2T0BIG6|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MGNKDVNNLIKYIKAIIFDVRIKEDIPEEFAEDNDFLEIDQTIKTLRESVRAIGIGDLLY
NIKGKGYIVGTLKNLQASLKTLKWQTKAVASGDFSQSVDFLGEFSDAFNSMTRKLEASIE
EVKDSKEYFEMLFQAIPDPTIITSIDNGDIFEYNEAFVDITGYTKEEIESKNTDELNFYI
SQGQREYLILELRKNGFFKNMEAVFQNKNKEQINAIVSSKFINIKGTTYILSVIRDITHL
KEIEKRLRESEERHRLLADNASDVIWTMDLEGKFTYISPSVEKLRGYSVEEVLKQSQEEV
LCPSSLIHMKQGLENAIKSVQNNQPFKDFRGELEQPCKDGSTVWTEVTVSGMYNEEGGFI
GMLGVTRNITKRKKMEKEIIKLSITDKLTQLYNRLKLDETFENELARSRISKKTFSIILL
DIDHFKLVNDTFGHQVGDTVLVEIANILKNNVGSTDVIGRWGGEEFLIILPEVEGKGGKL
LAEKLRAKIDHNNFMIAGHLTSSFGVAVYKDDISPASMVSRADEALYKAKENGRNRVEFL
>A0A518AA60|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MRVSVTFRIVAGLVLLTLSTLLIACSLKLAPNLNRVQMEDRARYCEALAVSSSLFLTQGN
TEALKGYLDAVVKHNPDISAAVLRQQDGSIFLQTGKTDDLTGTSAENRFNKVRIELREEN
HPWGQLEIYFPVENLGLLSFWQMPMVRYITFVVACCFLGFYLFLRKTLQSLNPSKVIPGR
VQEALDTLAGGLLILDTRERIVLANKTIARALRSNPDQLQGQVVSQLPWIQQAEGEPEDE
LPWTRVLREGTTHTGVTLSLESNATTVADCFVVSCAPVLDDLGRMRGVLVSFEDVTELEK
KKSELREMLQALHESREEIQKKNEELQHLATRDPLTSCLNRRSFYEQMETLWEQAQEQGT
PLGCILLDIDHFKSINDNHGHSTGDLVLKGIGGALMDLVEEPGVLCRYGGEEFCILLPDH
DIEQTDQVAERYRVAVESLEFDDLKVTSSFGATAISLGAENPQDLLDEADKCLYAAKRGG
RNQVVRWDRVPRDMDFSEPIAREPAPAQQEPVQEPMEVSTEVAISLGANMECLAQMIDAQ
DFAGLASVAEQVRLTAGRHGIFAITEVAGQLHQAAEKVDVIEAIYLTNRLMELCQSYQSL
HLQHTAD
>A0A8G1P4S0|diguanylate cyclase|EC 2.7.7.65|Qipengyuania gelatinilytica|TrEMBL
MTSNHKGAGYYGWPMLYGIAWLVCALVALNLTQGEDGIAAVWPSSGIFVAALLHFGPRRR
IITTAWIAAASMAANLWAGSSFLATTGYTIANLLEGYLVYALMGGSSAAKLILSRPWNMA
RFGAAAILAGCFSAIMAGVLSGNLTYSFLSSWMSTVTLGMLIMTPIILFIAQDPQDRRNL
LSLRSLWTALVVAILSVAAFGQADIPLLFLPVMAMAIATATLGLSGAAAALVIIATTGSV
LSIFNTGPVTLFFDTTEKQVFFFQLYLVALLVSSMPVAFLLAQRGRALAEIAENARLLES
AERAAKVGHWRFSPVDNSARWSREALRICGFDADSQPSLEDWFDLHHEDDRERVRSFIVE
ATSHALPFAFEARIRRGNSEIVHIDCRGEAEADRKGRVTALFGTMLDVTERAETMRQLEA
ARARAEREAAEVRMLAATDPLTGMPNRRCILANLAEAMDASELTGDPLSVAMIDIDYFKR
INDEFGHGVGDRVIKAIADILCDEAIGDDSVGRIGGEEFLFVFPSRSAEELDARCIAIND
RLGSTQWEQPINITLSIGIAELKPGWDERDLLRAADQALYDAKHAGRNRHSVHTA
>A0A377TML6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLFSSLSQMQNGKDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKW
GHMVGDRAIKHVADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQL
AFNVGGDTQIPITASIGFAAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A378FXN2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTAQTWRAHYAQKYQYSLRLFLLLNFISSSLSLVTPLFTVVRFTLPCALIVVCSALLLLW
HWKWPQSKINIPTISLLFGMLWAWHVVTKAMLLTPPHFNYLVIALLSILFIGTIAFSNNI
TAFTLHSLPTFLACLIMAEREQWLRMTYCFMLPIAGITLQNIIQKRSDAFTQGLMDKLMH
ERNTLNDLSMLDPLTGLYNRRGLQNRLDTLLALDGDNHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRNAVRSRDIVARLVERSLWCC
>W9BPP9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVVFFSTLLIWREINVLEEAYVANQRNNLSNVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A377XDS1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLISDLDHFKRINDSYGHVAGDKVIQFAASVLESHSRVDDAAARIGGEEFALLLVNTGEK
EAQAIAERIRLAVSAGESHLPERMTISMGVYTTYDNSVTAEACVQRADEAMYEAKNNGRN
>A0A4P0XGP0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MTNHKEENRLLSLYSMGILDTKSEERFDRLTRIATKLFDVPIALVSLIDRDRQWFKSCYG
LKIKETDRSDSFCTIAVDLSEPLIVPDATLDPRFKENKLVKNDPYIRFYAGHPVRLPDGE
IAGTICIIDTEPRVLTRDDFLLLKDLAEIVEDEFRIINEATTDPLTGICNRRSFALMTDE
SLRKAKKKKKTFCVLIIDLDNFKPINDNFGHSEGNEVLCNFADMLEDLSSSKSVVARLGG
DEFGVLLPESTYKEAEEFLHKLRAGITSYNLNSQKKYNIDFSAGIIEYDEKIHIERSAIM
QDADERMYEIKKGKR
>F8GNJ3|diguanylate cyclase|EC 2.7.7.65|Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)|TrEMBL
MATTSNDAWRATGRFHGKVSAEQDTNAPTAPYMPVYTPTLKARIAIITTVLAAVFGTGIV
LTALYDAHRDLHDALQVQQDSVVKLTASQLDTAMSDRIVLLSHQAAQLSGLLAQAHGAQA
AAVRERALDALSAAIPVPAAFNALLVADMQGNIVSNRGSGADIGDRSYFREAARSLAPVV
SPPIRSRTNGQMGVMVAVPVLAPNQAFVGLVGGWLDLSSANFLVEILHNRLGTTGYYCLV
SAGPEPVYIRHPDPAQARQPAQAVADTCGEDDSPAPLEFLTPARPVIARYLMSSTGWELV
ALLPAREAYAPLHQMQQRFLSMAGMAMAAVALLIWLAVRRQLAPLARLHKVVQASANDLS
AFERLPTRQQRDEIGDVTRAFIKLMRDVRERRQALDRSERRLRAVTDTLPSLLAFIDTDE
RYVFNNQAYERVFGLKPEELRGRHVREILGEARYARVQPFMQRALAGTAVTFETEDSDLE
YHCMESSLRPEWSADGSEVVGVHIHVQDITQRKLETQRLARMSRTDHLTQLMNRSAFEGQ
LHAAMVRSREHGTLMALLYLDMDRFKAVNDIHGHAAGDQLLQTFAQRVRRCVRERDTVAR
QGGDEFAVVLEDMTRPAAARRVAQAILQAMDEPFDFEGVSADVDVSIGVALYNGGPAQDR
ELMRLADVLLYRAKGAGRGRYEIGPPELAGELSAQ
>A0A7X0JMB2|diguanylate cyclase|EC 2.7.7.65|Rhizobium soli|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTADDGYKALAICEQAHVDVILLDIMMPGID
GFEVCERLKANPRTSHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLISRVKSLV
RLKTLSDELRIRSDTAQDLTLQDMMKSAAGQDAQDDVAQVLLVDGRGSSQERIVRALKPV
ADITAISDPQAALFEAAENPFDLVIVNTNFDDYDPLRLCSQLRSLERTRFLPLLLVTEHG
DDQVIVRALDLGVNDYIIRPIDPNELVARTLTQIKRKRYNDRLRLSVRHTIELAVTDALT
GLHNRRYLDNHMKVLFARATARGRPLSVCITDIDRFKSVNDTHGHDAGDEVLKEVAARIR
STVRGADLACRFGGEEFVVVMPDTDSAAAALIAERLRNIIEQTPFVLKSTGASLNITASL
GIACSRSGAETPEQLLKQADRALYDAKNSGRNRVVAAAA
>A0A2X3CV77|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MVLHSDPGALFKPFVRDELMDKMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATL
VNLTRHETNLVIGGFTLAAIIIILFGLYLRHASRTVLMNIINAIKTGDVKRAPRLEAMLS
KAIETNKQRELSYVRQATIDALTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSIND
TWGHLNGDIVLRNVAREGLQVLQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINV
ERRTWREDGLTVTFSAGLGEWNMEPLDKLVVSVDEALYKAKQQGKNRILRA
>A0A330QV36|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTNAQRQQIMFAHNSS
EMQIPEGFSVPWDESLCKRALEDQCTFSNDVANRWHSCIAAQELGIATFLSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDPLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFASARAQQQQVSLIFIDLDGFKAINDRFGHPCGDSFLVQVGKRLT
AVARREDIVGRLGGDEFLIVGSAQQPAAQQAYVTSLRQALCGVYFLGEQRIDYEGASFGV
VTCDPQSIDVEAALRAADEAMYQDKKSRRQENFIHID
>A0A5E4WXD0|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MKRTLLSAVSLTGRLRWLNLAVVGVVVILCGSLLIGSWGTYQRASDASLALEALKATLLA
MEKASAERGPANAVLGADLPLPNASVTALRNAREATNARLQDLLSALSTDRCDACGSSLR
VVERARLDLAAASANVDLLVQRPREKRSDMAVRDAVDHMIRVIPEFTSVASSRTDVISRG
VPDALHYVVLARLAADLREYAGQLGSHFTASLTTGKPLTEADQRTMERTLGRIDQLRDMI
AARMIDPPELGPETLGALNAQYFAAGLHYVATVRTLASQPEPVGPTTAEFAGHYVPTMRA
ITDFRDSMLALAQRKVDAQVSIALKWLIGTAFATLALVLAIVVALRSFRRSVVQPFEAAT
RFVIALAQGNLDAAVPGEGVPMRRPQVRAVFDALRVLRLNALELRQLRGERNRLLGELEL
SADTDPLTQLMNWRAFARQARALWAMPSPGRVALIKLDIDHFTQINATWGHDVGDDVLRR
VSAVCLNTCQPGDAVARLGADAFVILARVLDPSRAQQFADLLRGRIEATTLPLPNGERVP
LNASVGIAIGDPATFNATRVSSGEPATVSALLSEAERQLHAARLAQRRAIE
>A0A486R1I0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQLRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDII
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A2N9LA75|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MIGPKMLDAAFRYVLRNPPRLASVDGSVETLLGYDQRQFLTSKVHLRDRVHKDDIPFFDS
LFASEASQPSGGFTIRLRHADGKIRCVKGSYTRTGTRGGEVELEVHLADARTVKEPGDAS
LVNSFKTLIEQTADYIYIKNRNHVILAASRTLPSLTDSAQDRVDLVGTTDYDNHPEEAAD
AYYELEEKAFAEGMRVNLIQQVRNQDGTTSWIDNRKYPIGGPDDEFIGIFGVAPEITNYI
ETQKRLRESEERLRDAHEIAELSSYVLDIPNQRWIVSPELAALLGIGEDYDRGFEQIWPL
IHPDDRPAMAERFQEYFTGGRDAFDSEYRIIRHTDGTVRWVHTRGRLERDAQGKPLALRG
TVQDITERKQAEAALRENKDLLQLFTDHAPAALAMFDREMHYLAVSRRWLEMHSLLDRDV
IGRSQYEILPEVPESWREEHRRCIAGEEIPTEEREFVRADGTVQWVRREVRPWRKGDGSI
GGIVIFAEDVTAKKQAEERLRLAASVFTGAREGILITDLKGTILDVNEAFKRITGYTREE
VLGKNPRLLKSGLQSKEFYQKMWSSIQRDGHWSGEVWNRSKNGDIFAETLTINAIRDVNG
QPTQYMALFSDITEIKRHEQQLEHLAHYDALTGLPNRVLFTNRLRQAMAQMLRNKQMLAV
AYFDLDGFKAINDGHGHSIGDALLTAIAFRMRRVMREGDTLGRLGGDEFAAVLLDAASPE
NVAPALQRMLAAAAEEVQIGDIDLRVSASCGVTYYPQPEEVDADVLLRQAGQAMYQAKLS
GKNRSHNFDPSEDLNTRSRHENVEHIRQALANRQFVLHYQPKVNMRSGTIIGAEALLRWQ
HPERGLLPPGMFLPVIEEHPLTIEIGQWVVESVLEQMEQWQAEGFTLPVSVNLSALELQQ
PDFVDRLHKQLEAHPTIKPSSLELEVLETSALEDVVQTSQTLAACREIGVSIALDDFGIG
YSSLTYLKRLPANVLKIDQSFVRDMIDDPENLSILEGIMGLAAAFRRQVIAEGVETVDHG
LMLLQMGCEQAQGYGIARPMPANQLRAWAATWRPDPRWSNVPPVHSENRPVLYACVEHRA
WLSAFEAYLLGKRAAPPPLEASHCRVTSWLNAEKQTARGTFSNVRAIEMLHQELHILAAE
ILASQSEGRNSDGLALLQQLHHLHEKCMSRLRAFTRTGRHRTARRARIVSKK
>K0PMT5|diguanylate cyclase|EC 2.7.7.65|Rhizobium mesoamericanum STM3625|TrEMBL
MTARILVVDDIPANVKLLEARLVAEYFDVLTAGDGYQALAICERNQVDLVLLDIMMPGMD
GFEVCERLKANPKTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRIRAETAHTMGIDELLRSGEGRGDESGQVLLVDGRANSQERIIKALKPIAD
VSAISDPQAALFEASENPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPILIITEQGDD
EMVVRALELGVNDYIVRPVDPNELVARSLTQMRRKRYNDRLRASVKQTIELAVTDPLTGL
SNRRYLDNHLSTLFSRSMARGRPLAVLITDIDRFKQVNDTYGHDAGDDVLREFANRIRST
VRGADLACRYGGEEFVVVMPDTSPEVAATVAERLRSVVETTPFQLKSSGQELSVTASFGI
SSRISSVITPGQLMKQADLALYQAKTGGRNRVVAAA
>D8G759|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MQLLPREFQQFFLYSKNIGEIIKFRLKVGVMRNRQERLLSNLDKNKKVSDRSSVSEALRL
RDRAIAASNNGIVIADARLPDCPIIYCNPAFERITGYSQAEIEGKNCRFLQGPDTDPAAL
EELRNALREGRACEVVLKNYRKDGTHFWNKLAISPVRDKKGQLTHFIGVQSDISYRIEAQ
ESLHQATAQLQTILEAVPGTVSWISSDLRYLGVNHHLARLHGLSPEAFAGKDIGFLGSSS
EFCQFVRSFFASPKTEAIEEMTATLPTANGPNLRHYLIVAQKYNEGKAAFTIGIDITERK
LAEEALVLTRKAVESSSDAVGMADARGTHIYQNQAFSELFEYETVEEFNASGGIPIVFAD
PAVAEDVLKTIMSGNSWRGEVTKRTRTGQTIQVLMRADAIKDAAGKIVGLIGISTNITDR
KRTEQELRQSEQRFRSLIENATDIILIVDADGICRYVSPSQERILGYSREEVLGESIFNW
VHPDELHLVRRVLDGVIKHPCVGLGLAEYRVRHKNGKECVLEAVATNLLEEPAVQGIVVN
CHDVTERKAAEDQLLHDALHDALTELPNRALLMDRLGQALARARRNPNYRFGVIFLDLDR
FKVINDSQGHQAGDRLLYAIARRLMSCLRSGDTVARLGGDEFIILLEEIEDVSVAIATAN
RIQQALEQPLHLEGHKVTVTASMGIALSTPEYQWPGDILRDADIAMYRAKALGKARYQVF
AAAMHTHAVALMQLESDLRRAVELTCGEEGAEEGARGQGLGAREREEETGDWGLEIRETE
EENSSLAPNPYTLIPSSAPHPSPLTPSSPFVLYYQPIVSLSRGIVVGFEALVRWLHPERG
LVTPAEFIPVAEETGLIVPLGQWVLREACSQMVKWQKSLKSHTPGEFDFNCRGVSLNSNP
ELWAQQFQLGDIDSSSKLDNTLFGCDLEVSVDDNQSLRHRPLINKAVEEPNLPIPSCELP
VSNYQLPLPNSQLTIAVNLSGRQFAQPDLIEQIKQVLEETGLDGQYLKLEITESVVMEDG
ESAVTMLSQLRDLGIHLCIDDFGTGYSSLSYLHRFPINTLKIDRSFVSRMGVDGDNSEIV
RAIVMLAHSLGMDVVAEGVETSHHLAQLRSLGCEFGQGYFFSKPVDSEAATALLSPALQW
>W6KF94|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MPHDNDKARILATLDRMLDDLDRHDLPARTTFLAAFYAEAVGEIAGLTDALNQVEQPPTK
ADLNQKTQVVCSRLLSLPEFEEFTRSGGLMAHQAEEILSSATAMEDRALAYGQHLGLATE
KLDDADDREEIQKIIAEVSEETGGLIDQNHGLVEKLRESTETIQQLQSRLSEIQDLAAKD
AVTGLYNRRYFERALNEMLPDPRNHEGRLCVIFIDIDNFKGFNDSYGHAVGDMVLKLVAR
ILQGSVRAQDICARYGGDEFVVALPGIVLDDAHHLAERLRARMASTPLRKRGTEENFGQL
TISMGMTAYHHPESADVLIDRADGALLRAKDAGKNILVLSE
>W6K5V2|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MTSQETGPAETPDGAEEGNDSRDLFYTTFLSALLDHQEWIGRVNRAIHLGEGADPDIVGD
TSFRQTRFAQFLETVQPHLMPHVEAVRAALFEMHQDAQKLVEHASEGKFSAADYDTWLEA
MKKFRTVAARLADHADDLSPSVDEHTRLYTREYMDQRLREQCDLARRASQPFCIGLSELD
QYEEIERTHGFPVIKAVLREVARRFISAVRLYDNVFRFDDQKFMFIFPTTRLRDAIMVSE
RIRADVASQPVETPAGEISVTISVGVLEYGFGEVPEDLLKVVDVNLAHARNEGRNRVVS
>A0A6B8NLG4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MLDSLFKKLFVLSTTTLMLTLFIIISFAKVAGEQRETKAELDQIIDLQLCVDLLRSQLWV
FLQFGDESSLNQVELAQAELATKLTAYKQNNSQLGNIQRMNHSLNALLNKEKQVYFLSIN
GLDEQGSANINARGLLHSRYNMIVQNMTEELAYVHQSVLNRNANSLHQVMLYAAAWLIIC
SVLVSATAWLISFRFKSGAEAMKNAIIDLAEGKLDSKVEAVKMDTEFRIMAQFFNQMTMS
LCETTVTKQELEEEVMRQTQQLKHKQEQLIFLSEHDPLTNLVNRRAFDKALENAIVKANR
TQCKLAIFFIDLDDFKSVNDTFGHEAGDAILVEVASRITAAIRESDFVGRFGGDEFVICL
DLLHDFDIVAKKAEQLLDAINAPIEFNGRTLKVGASIGVSYFPDQTKNKEVLLSIADEAM
YRAKQMAGSACFDGKTTVCKKGSKSVRLTSIND
>A0A6B8NGJ9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MSFSLVTTNWFRLTFPVLLLAMIGFGMNNVINLTQANLGITSNLPYFLFFCVIGLGHAFK
QCRIAMVALTMLVVYWYIQEYLQSSLSTGSTLLELSLLAFVVPIACALVYPYKERGVLSR
AFIVYIVTLSLIAIWCYLILAYFYEGGFQNFDETFLYSEPSVSRLPLILVLYSVGAILLS
AIVVLRVNRIIDVVVYSAITLSSVTFTFFHVQYVSSTMFTLSGFLLLIYMLSASYELAFK
DRLTDIPGRLALESDLRHLGKRYTIAMLDIDHFKSFNDTYGHETGDDVLKLVASKMQRVG
GRAKVYRYGGEEFTVLFKNKDVDEALDHLELLRSSIEEYEMVVRNEKSRPKDDKSGAKKR
RKSNSHDHVNVTISIGVADHENADSVSEVMKCADAALYKAKRAGRNRIESA
>A0A149VYE1|diguanylate cyclase|EC 2.7.7.65|Ferrovum myxofaciens|TrEMBL
MNDESVVPDTLAEDSLLLQIRALGHLPSPSSTALRLYALIQSEDVDLHKVAEVIKRDVAL
TVRLIRMANRPGGTPGRPVASVEEGLMRIGLKTVAGLAVGLSVIDDAVASSAPDASAYLA
LCRHSLAAAVLAEWMCDRPEIPVSAADLFTCALLARIGQLALLRFYPEPYSVLLRLNQNT
HELLDAEREQLGIDHQAITLALLQEWGFPDPLTEAIRISEAEPELRVGNDRSHVMAQILN
FAWEAAPALISRHTEKINGYLEHGLALLGQSVSTEELPGMVEDIIGHWQEWGSHTPGHDS
SNKDIAPNSGEAESVTTRLLLVGVPLAIRQSWESTFAGRGYGVLNVDSWGAVTTQMTNES
VGFLIIWQDEPHILGEQEKRLFESWTGEEQRAIVVLVPELNAPFAQELLEIGADIVLPCT
VSVPLLGAQLARLEGKLVVARNLEAERSTHRKLLSELVLTTRKLHLQTLTDPLTGLANRR
MAEAFLKRHWFQVERRNLPLGVLIIDLDDFKRINDKFGHDAGDAALRAFATVLKENVRQE
DLAVRLGGDEFLVVCPLAQVSNLEYLRKRLIEVARQLTLETGPLSCSIGFAESDRNTMKS
PSELLKQADEHLMRLKRNRPGKG
>A0A6C7DCD7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 56:b:[1,5]|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5B7XEW5|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MEHDNVSGKDAFSARHRFHPGRVVNICFIAVLIFSTLLTWREAVVLEDAYAASQKNHLET
VVNSLDRQLEFSVEKLLFFRNGMRDALETPLASTVLHNTVSHFRDLQGKPFWQLTFDVRR
TLPLNGVSDAFVRQTTSLIRDEERLERELSAAFEMGYLLRIDAPAAHAKRVVYVSRAGFY
VSTEPADWGNDIISRYYQLVTRPWYTGQSERENRTRSVRWFTQGAEEGTVTVSVPVDYQH
YWYGALGIDFTLTGLKKLLQDAVDGNGEGEFQLYDNGFNLLVTSESNADDVNHFDERERA
QIAAALEKDTEGDLRLGSRYVNWQHLDHFDGVVLRIHTLREGANGDFGSITIALALLWLL
FTGMLVVSWIVIRRMVSNMYRLQHSLQWQAWHDPLTRINNRGALFERAKALAKRCEQHKQ
PYSVLQMDLDHFKSVNDRFGHQVGDKVLTHAAGLITRTIRERDVAGRVGGEGFCVVLPDT
GPVQAMVIAQRIRERINRREILVKKSQTTRVSVSIGVSSAQESGNYDFEQLQSIADARLY
EAKQRGRNQVVGQDEKK
>A0A6B8N0G3|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MIVRYKRFLSGFCVLSGLAILVTTISYQTNPESYSDLLFEANTLFVLLFIYFVSRELYRN
NTFIKWGLILLVVNQAYDILTEIPVLDQWTDNNEFTHTLIEDGGIQIAYLLIAFGVTRLF
RQMSEHAYTDELTGLFNRKKLFSIARKQFDLIYIDLDGLKQINDTQGHASGDLAIIRFAQ
AVNASVSPTDKAFRIGGDEFVIVVGPGEGEAFIDRIKKDLVEEQILFSYGIEASTPETLK
ENLIKTDKAMYEMKNSQRKGAESD
>A0A1V5GK36|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MKPRRKIALLTSCPETGHGRRIMYGLTAQCKKYNYDLAVFCALSALNTAMEDYTLGEKNI
FNLPNFDLLDGVIVDTAPLLDGHGTEHLDVIYNMLKEKCSKPVVALDMPIHDIPLIQNEN
EEVLREIVRHVVNVHGKRKVCVISGARDNFAGRFRLETYVDELEKLGIDVPEEYRIYSDF
WYTGGSKIGQDMVDGKIPLPEAVVCGNDYLAIGLIYRLTKNGIKVPDDVIVMGYEASEEG
AGYDISVSSYEVNDALSAANCVDYLRQRIDPGLDIDPYTTTPHLCPGMSCGCQPDYARSV
KAIHDHLYFTCPNYADEDIKDNVDIGLLMESYISEEFTASETIADCIRNINLKTYLIFPF
LNFYLCLKEDWMDVRNDITVGYPDKMKIVAVNTTVHELYFHDDEHSIVFDTSLMIPRLYD
NNDEEPSVYYFAPIHFSCNTLGYAVLQRSLDDKHTPNLVFRNWIRFVNNALEMARAKQRL
LTMSVRDEMTGAFNRRGMYIEVEKMLEECSDGDNVFVCVIDMDRLKFINDNYGHHEGDFG
IKTVSNAGFAVTGKDEIFVRAGGDEFYIIGVGDYSAESGKDRIKEFNIAIQRLTDKARKP
YPITASVGTALRKAEKNINLEDLISKADEEMYQHKAAKKVQRVS
>A0A1C3JMP7|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MADFFIITKALKDLYNNSQRLVDNESSTLQLINVNGLIAHLCFIVLFILIDINWLAIMNI
VSVIVWCVSIVCTIKGRHRISVFLIAIEISTHATVTTLTMGLAAGFQLYLWPAVLLMCVL
PAAHQKSSFWCLSIIIAPLLLLNLFAPLEKEAYRSVYNGVYLFNLISASLPFILTAIMVR
MIFMHNFQHMEQRAYNDELTGLVNRRRGYEILHAAVNKHQYISLALGDIDHFKRINDSLG
HLKGDEALQKIADYCSKQLDDMGTCCRWGGEEFLFIFIDQPYTHVRYKMQTLCEKMPLKV
KMEGLDSPITCSFGLVSLDKHETLEQALSEADKRLYQAKDAGRFRVVHEKQPIV
>A0A2U3L845|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MAVSAVLVLAGVLHGQEYNFRNFGVTDGLNNLAVRQVYQDRVGFIWVSTENGLFRYDGER
FEAFGPEQGIPSTSGAAFGEAPDGSLLVGGNFGLYQLSGTRFEKLPGAFKTVSWAQGIQS
DGKGHTFIGTDSGLVELYSEPGRDGFAVRRLPQAPGTSGAGAYGILVDGDVLWYGCGEQL
CRMERGGTTVFGRDSGLPDRALLTIQKDRDGDLWVRARNAGVFVLPAGQARFRRPDAPIS
GISMGIAADAEGRILILLPDGLLIRDEKGWQKIDRSVGLRGVVYAAFEDRQHSLWIGLAG
RGLAQWRGYREWESYSSASGLASDIVYEILPRTDGSLWVATEGGLFRGTRRPFSISWKAV
AGLVGFPVHSLRMAPGGDLWIGTETRGAACIHARTGRVQWFGPKQGLSGTAAYTLRFDRE
QRLWAATELGLFVARAPYRKFSRIAELPSTRIWAIAEGTDGTIWAGGAGGLFGYLAGGWK
NWTRADGLSNQEVLSLGAGADGTLWIGYRHGGGIDRIHPQPGGFAIEKGVQRRGSDGLVY
FLEFDASGRLWVGTERGVDTWDGASWSHYDTRDGLAWDDCNLNAFAEEADGTVWIGTSGG
LSRFKPRAERAPEAAPEVVFTKLVMGPTNVFGQRNPSFSIHSNSLLARYAAPNAPREDAV
IFRYRLEGTNSTWTETDKRELRFAQLAPGAYRLQIEARDADGVWSGHGAEYPFEILTPWY
KTWWFVGTCWLIPLSVAAGLLRLRMLAAQRREHELQRIVDEKTADLRRVNEDLLRLSSVD
SLTGLANRRVFDQTLRMECARLKRIGSAVSLLMLDIDHFKALNDSEGHQRGDEYLKLVGS
ELRRHAKRQIDLAARYGGEEFAVILPETDGSGAAQVAEAMRLAIASLQLPHPASPVAPFL
TISAGVATATRQWHSSLEELIAAADQALYGAKRMGRNRVNLAQQEAVPGTMVIVDSLHPP
Q
>A0A2U3LAI9|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatobacter kueseliae|TrEMBL
MTKALPRTRVILTLAGILWLAHAAVIAFLGANPTGGLWSDVIQLALGGLLIYAIAQAGKA
SEGLPRSFWRLAAVAYGLWFIAQSLGVYSDLVTSPTALWINNMLFCFWFVPLAMALLLDP
DHEAGRLDALVALDYIQAVLICVAAYVYFFYLPKAVSPGQLPHEVWAPYFVGYGLVALAF
VLRALISHSQDTRRLFGRMGIFLALSGCADALFYYGPGQSLNPGAWFDLLWSGLLIIPLL
IAVTWKQAEALDVALEPPRRERRAYTEIFYLLYPMLVLFMSLRIARERLGLAATLLFLSF
VCFSARLLITQNRLVVAKDALRREASRDGLTGLWNHKAILEILARELLRGQRHSDAVGVI
MADVDNFKLINDTRGHAAGDNVLRIISSAMAAVVRPYDSVGRYGGEEFLIVAPGCGLAET
WELAERVRTHIAACSIVVGGEARVSVSLSFGIAAGESANDSEKLLHAADAALYLAKSTGR
NRVEPRISRAASAGSDSAPASDKDFWL
>A0A1V5G8B5|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MIFAAAFTDSLNSKLLRITLAAVGINAITVTVCMVFRICDFHYLLPITHMTIAAGMVFLV
ILFAHDLSIKKKRNPGYKYLAVAFGILVISGIGDLLSYYIPSKSYDSAASSRCGLLIFTL
ILLWYEIISLAEVNRKSAAGEVMNRLAHIDTLTGLGNRTSFDESERRLSEQSSGKCAIVQ
LDVNYLKQVNDNYGHIEGDRHLCATADCMKTSFGTLDNAECFRTGGDEFVVIIYGNDAIK
DYDKAIRLFNGQIQKYNSSSKPQIPLSVACGMAELDCSLGTDPHVIEKLADERMYENKQL
LKQDSLTLI
>I3X9W9|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium fredii (strain USDA 257)|TrEMBL
MQTATSNKTPTPDIAAQITHAMRMMGVAPIPRNYELYYEAYLGSNPQLSKELAALGSRAT
QDELDAIGSRYFSHIHHSRGIERAHSTLAEKLTELVTLLRDEQYALESYNRVLDEAYLNI
TNKSAASADILRHAIDILSEATADTMNQGKERVQTVVQKSFEMEAIRQELDEYKRIANTD
SLTRLGNRRAFDETLAAVYNNEQLRNYTGLLVVDIDHFKKVNDSFGHPVGDKILSTVGTV
IRANLRRDAFVARTGGEEFAVILNDSTQEECLQVADRIRSVLSNTPFKNSKTGVNYGPIT
LSVGVCMATAADDPLDLYHKADIALYAAKNSGRNRTVLFEDGMRKDSGRNWLIYRR
>A0A379K1R1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas oleovorans|TrEMBL
MRKVFRRDGDSLLRLGGEAFGVLLPGTTLAQACDLAEHFRQELATEGLLLAGQRLELTTI
LGVGCFSSSHDGDADAFFKRVDGALYRAKREGQLPLNTALPEAHGGFSRLLF
>A0A7W8XMP1|diguanylate cyclase|EC 2.7.7.65|Rhizobium paranaense|TrEMBL
MTARILVVDDVPANVKLLEARLLAEYFDVLTAEDGLRALAICESTQVDLVLLDIMMPGMD
GFEVCERLKSDPRTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRMRNETARNFGIDDLLRFGEGRADESGHVLLVDGRANSQERIIRALKPIAE
VTVTSDPQAALFEAAEKPFELVVVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
EMIVRALDLGINDYIIRPLDPNELVARCLTQIRRKRYNDRLRASVQHTIELAVTDALTGL
NNRRYLDNHLKILFNRSLTRGRPLSVLITDIDRFKQVNDTYGHDAGDEVLKEFAARIRST
VRGADLACRYGGEEFVVVMPDTPPDVSAAVAERLRAAVETMPFTLREAGIALNVTASFGI
SSRLETVETPEQLMKQADRALYEAKHGGRNRVVAAAA
>A0A655QCT1|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIAVSIVLINTPKLLFEDKIHAYEKEQLQLTVELQKTRIDYASLILEHLETHSLTPQLQE
FFNLYHGNLCVLDENSPQQCPLSIIDAVQSTTSASDFVASTSVNITFAEGSILFFQVQGK
QIRVLWFNHASFWPAPQKNISLVLVRGNHIQFLDNPIAHYNALLNYTILRHRDDYGTLQF
ENMELSFLRWNLGEYQLISVFNDKVRLFNLIYWVMSASLTLLLTLTWFLTRLNLQKVAAQ
RHVYIDNLTRLNNRHFLNKISTKFIEHPHSIAAMIDIDHFKKINDQYGHITGDRILQAVA
SCLRKNVRDGDTIIRFGGEEFLLLFQAHSNKEAWYMLDRLRQRVKDDHSLYGTTISIGFT
FIDGSLPAAISRADTALYQAKEAGRNQVVADSEKENDSAADLPIQC
>A0A655VJ46|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQMWKALQDNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALE
NRLRELSEKDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCIAIIDIDHFKRINDKFGH
NEGDLVLRTVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHH
QQVTLSGGVTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMEXXXXXXXXXXXXXXX
XYAAKIIKSYLTACSDFHSALSSVLLSPPLTFASCTTLHRLVLLQTHLNSLVLQVGGK
>B5F2Q1|diguanylate cyclase|EC 2.7.7.65|Salmonella agona (strain SL483)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A517YX59|diguanylate cyclase|EC 2.7.7.65|Poriferisphaera corsica|TrEMBL
MSTYDSFPNRILDQVNDGAYFVDRERRITFWSKGAEKITGYKADQVIGRHCYDNILMHVT
DCGKCLCKSGCPLQATIDDGIVRDAEIFLHHKDGHRIPVHAHTNPLRDDKGHIVGGIEVF
SDESSQANNIQRLKDLEKAAMIDPLTNIANRRMLSSTLEMRFAEFKRNDWQFGVILVDID
KFKNFNDLHGHQIGDRILQLISRTMKHACRRYDLVGRWGGEEFLIVVGHTDTKQIVKTAE
RLRVLVNQSFIQHAGCRLTASISAGVTLALPHDTIESLVSRADQLLYESKHRGRNCVTSD
LIRPESHENASNDVPACSVA
>A0A655VA94|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MQSPLYVEQKEKLNYLSRIQFALILLTFSCVGLVSFILHKEATHHRVLALTDPLTGLENR
TAMFAELERXXXXXXXXXXXXFSLFLLDLNGFKQINDTYGHQMGDAVLKQVAYRLNNSIP
SFDYRVFRMGGDEFAIILSSINSTEQMMMQRMIKQCFDHEFELSGDLRAKLNTSVGVSTY
PLDSTNLSQLIHLADKNMYEMKFLQKXXXXXXXXPKVYHRL
>D8E6L1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 119-7|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNPSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSEN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A7Z8BBP7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7Z8BQV1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNDHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A7Z8FJK8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MVIRGMTISLPWFAFINVSFALIILLRRVLFNDLTPPWLNEKSLIHSIDISATGILLICS
GLLLIPRQKTLPIQVLLVALSLLWSWCSYHFIAYWTLQFAYPLCVLLMLSGVVALYFHTP
SLLAFVIPLWFTTPIASLMLNQQINIHFAVVWCIFSLALYGGRLILLRWFEEAWIQNSYN
NQLINRLDALAHRDPLTGIANRRAMNSILHDAMDNGGSFALIMLDVDFFKRYNDTYGHPA
GDRCLIQVADALQRSTRQSEDVVVRYGGEEFAIILFNATLPEAETVAARVKQELKLAAIP
HQASAVNAFVTVSQGITCSAPAKTAEQIISDADAALYRAKESGRNRWAL
>A0A8B3FC68|diguanylate cyclase|EC 2.7.7.65|Pectobacterium parmentieri|TrEMBL
MNELRNVDEQRDNGEQDYNQVITSEWMQLITTTSQKSFNLLQTLAAQKASDFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIVDILTNTGSHLADLINYQRKIGQIHARIGIPVD
LVERGARRLKWQLYEDIAQAADDKTLCFDAMRYASISMDIAIEIMNKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIATIITETDDYIRNYSNTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLTMHSNTPLSIAMIDIDHFKSVNDTYGHTA
GDSILKRIAEILYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHTIHL
QNGESVTMTISAGIAVYSGHPDYECLIKAADDALYQAKANGRNRIEYAPE
>A0A200LH78|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A7Z8B9I8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A378IV13|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MLSANMIPRHELQQIIIQLEQALSEHLQWHSTLLRALVCHLPIDNNNLQADGHHKCIFGQ
WLCTSAPKELNDYPGFLTIDEAHKKIHLLALQLVKETATGNISPVSYDLFSSALTYLQLE
ITALKGELESLLYNRDALTGAISQLGILPILREQQELAKRQDQNCCIAMVDLDHFSEINE
QHGRYIGDKVLAAVAHYLIDNLRPYDRVFRYGGEEFLLCIPFTGLAPSQKVVERLRRGLA
TITIEAGQQEAIRITVSTGLALLDPHLPIEQCIDHSMQAMSTAKAAGRNCVKIWETSNE
>A0A7Z8BD04|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHKGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8G1GVW9|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D13|TrEMBL
MNHATLFSSQLQQISHNLEQHAPLPALALIHEMNSANPRVNPKQKIALLLLKAQAETELG
QSHALSNTLNEALDLSQGADLALERLQIMNQLADQMYTMGNYRQSIQLWLTCIELGLELG
DTTTAIAAFISIGGIFNAADEHERAYKLHLQALQYCRNIATPYIYCTIRLYLAADAMWLK
RPADTLRLLDEADPIIQQHQFHHELAESFLWRAQALLQLNQNDDAIHYLNQALAYAEQTH
HFWAQIKCGHQLGLIYTQQQRYSEAEQCLLEAQAIAKDSEFTQLLRDCLLALSTLYEQMG
QAKQALLALQAAHDLEHGLAKRAPILELEPRILKQLALLETRFSLEISRQENRQLIAVQA
QQSQKLDQLRTEVEQDPLTKLANRRWLDTHLPQQLHNISEQEPLSILLLDLDHFKKINDD
FSHLVGDEVLRELGFILQRACRDIDTPVRYGGEEFLLSLRGLNLFSAAKVAERIRHQVEK
HRWPASLGDRAVTISIGVAQAHQGDSLSSLIERADQALYCAKSLGRNRVEL
>A0A380K3U0|diguanylate cyclase|EC 2.7.7.65|Streptococcus gallolyticus|TrEMBL
MEEIFYFTPKIGDFPMNYLDSEDAARLKANVDRAKKGEIFTFMDTIKTGDKMLYWQNMYS
PIYNNHQKVIGVFCFVLDITEQRLHKLEIQRMAYEDVLTRVHNRQYIELAFEECLTHKEE
QITVIISDLDKFKEANDTFGHATGDKILIKFGDILTKIMPETAVITRLGGDEFAVLLPEV
SENQAEFLIKLVQAEMTVTDIGVTASLGAYTDSYQSHKTFVDFCAMADKKMYENKSQKDK
ADDVSRCCYCYSCL
>A0A656BH62|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRGFCIQFITITPKFPLPSGAEMSIISAPVPGRNRTLSGFLVSLTEGVPFIMKLHHRMLR
HFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALA
AEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPA
FDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSI
GIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIF
YTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFI
TSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTPELEQRLQKL
VQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAIRLGGDEFCI
ILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKASDERLYVNK
QNKNSRS
>A0A5J0FAJ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Vitkin|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1V4I577|diguanylate cyclase|EC 2.7.7.65|[Clostridium] thermoalcaliphilum|TrEMBL
MHLREKAQQNLSRELFIEIKVDGTIQDVTSNCVNIVEYTKEEMIGYNIKEIFQNNEFGAI
LDKNQDFEIREITIKDKNNKNIYMSVKRDFIKEDNREFIYLSMLDITKHKEELNRAKRIV
RIFERSNDIICSYNLEGEYRMDYISPSIYKNLGMTIEENKDNPMMPLEVVHPDDYDLHLK
KFKGEVDYDQYFETRFKHKDGRYIWFEEYITPVYDEEGKLVAIESIVRNIQKRKELEEKL
TYLSYHDTLTGVYNRTYFEKYKNELNKEKNRSVGVIICDLDNLKPINDNLGHEAGDKLLK
ETARLIQENVGADILVARIGGDEFVILMEDIECKEVKARVNAIIKSIDNYNSCDPEIPIR
LSMGYDYNENSIGCMEMIFRNADRNMYRDKHSKKVG
>A0A0M2WX80|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MGDQQKRLQMALEAAHMAIWDSRIVDGQVIDGTVSWSAKGATLLGLEERPLTQPFRAFLD
CVHPGDREKVLSVLEDGVRRCEGYALQYRVVWPDASEHWLAAKAQIFMDADGHPERTLGI
IWDITEHMERELLIAESKELAEVTLSSIGDGVITTDPQGKTRYLNRVAEQLTGWSNELAQ
GLDIWETLKLVDEHTGEALEHVAIKCLRQRQAIGISTHAQLVTREGRHIAVEDSAAPIWS
RDGEILGAVVVFRDVSHERKLSQQLSWQATHDALTGLINRREFEHLVAGALHTAKQDGHT
HALLYLDLDQFKVINDTCGHGAGDVLLQLLAKMLQGRMRDSDILARLGGDELGVLLPHCP
LDHARQIGEQLRQSIREFRFAWDNRSFELGVSIGIVEINQDSKSMSELLSAADQACYLAK
EQGRNRIHVYQESDVMLAQRHGEMLWISRLNEAFAHDYFRLYAMPIVHLHDSEEHHDEVL
IRIRNSKGDLILPGAFIPAAERYDMMLPIDRWVIRAVCAHIESVRDSLPPLEALAESRRR
APALYSVNLSGMSLADTGLHDYITEQFVQFAIAPEQICFEITETAVIANLPKAQIFMRQL
KAMGCRFSLDDFGSGFSSFGYLKALPVDYLKIDGVFVRDIATNAINRAMVKAINEVGHVM
GLQTVAEYVEDEETLAVIRELGIDYAQGYAVGSLRPLTAGVD
>A0A0S4LFI5|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrificans|TrEMBL
MIKILLVEDNDVDARLTQDILAEWGMEEFDIIHVTRLSDAVTHLARARFDAVLLDLSLPD
GYGLSTVRQMHAANPTIAIIVLSGLNDQTLALQAVQNGAQDYLVKGQGQSELLARSIRYA
IERKRAEERLTYQAQYDQLTGLVNRTLFRDRLIQAMARSKRLQQPLGLMLLDLDQFKPVN
DTMGHNVGDQLLKSVAERLQECVREVDTVARMGGDEFTIILEGLTCEEDITLVAQRITTS
LAEPFHLGEHKAVIGVSIGITVYPTDDHEVDELLKHADAAMYRAKQQGGSSFQFHIPADS
PSSPA
>A0A1Y6M9X0|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MRSQNKKTYQSQLTIFKNFTIFFCTLSTLYLIYNIYHVKSFHQQYITKIKLVYSYTRRFG
SYYNNTPEKYKAADHYKKDNVSLVVNKATQVKVLSNGISKLRSELNQLTNNNIWTIAVFE
NPADYAHFDPIRPEYLNQFDKYGENSVMLRIVAREGILNTYQSFYGCNLKLTENYIENGS
NTHIRTLYYPIYNKMHLDALLAIDIKNKVFSEFLEKYNKQHLTIINMNKHNNIYNIIKLL
PCSEKNPITIGINLLSIFKAIFFPALLLSLFYRYFRVYLIKKKYHIQRDQMTKFYRRDYY
EKKWLKQHDFNLLIIDIDHFKKINDNYGHEVGDDIIRHVANRINNCIRAKDIAVRWGGEE
FIITFKDMTNKQLHIKAQQICTSISLSPILGLDITVSIGGTTATNTHFNNVYKIADKALY
YSKHNGRNQYTIV
>A0A1Y6MBY7|diguanylate cyclase|EC 2.7.7.65|Photobacterium andalusiense|TrEMBL
MNISHSIRKKIIHYTLLCLSLLIVFNLSYWSYNQYINIHELLSRNKAVTENNVATIISKH
TNLLTAITNDDIVKDTSLLLAQRIEIVRPYQEAFNIEILGISDIKGNAVTTYSDSIENIS
YRRYFQQAIQKNKLAISNLIYSPISNSYVYIICKAFTNANDSGTIFASVSYSEIKNALAY
QESTSIRNDILNNCRDSNNNCRNIKILTNDKLYSSLDNKKISQRIKNKKTFSYYTVNNNY
QLEKLTLRPLENTPWYLLTTLNYNEFLKDKFVFIIINILISILASVGLGFYLMKKVSIIT
SPIDDFIKESAGIIPIQPQSKNDNIAINHHFNNIISTTKDGVYCSRTNLLNRKYFIQHAN
ISIQKYPNDFALLFIDLDNLKIINDTLGHHYGDDVIAMFAQHVTSFFNHPTDLIGRFGGD
EFIVLTNNYNKEFDLIAKLQKLIVDLNGSVSNSTLTIPFSASIGVALTNNETRDIEQLII
NADKAVYDSKKKGKNCYSFYICH
>A0A381G8G3|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYDYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A8I0MSC9|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
ALEVGYLLRLAITRTSMSQQAMYVSRAGFYVSTLPTSLSSDITTRYYDYVIQPWFTGQSQ
RNNRMRGVRWFTSPSPDLPYEQQRVTVSVPLDNHFYWLGVLAMTIPVSAVERFMDEAIDK
DVEGEYQLYDSKLKLLAGSTSELRNANTFDERELAMLAHDIEQDTVGGLRMGSRYISWQR
LDHFDGVLVRVHTLSEGVQGDFGSISIALALLWALFTAMLIISWVVIRHMVSNMFVLQSS
LQWQAWHDTLTRLYNRGALFEKARLLTQRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGD
RVLTHAAGLISGTLRTYDVAGRVGGEEFCVVLPETSLAQAEQIAERIRQRLNEKEILVAK
SATLRISASLGVSSTQETGDYDFEQLQSLADRRLYLAKQAGRNRVFAADQS
>A0A5C5WVA3|diguanylate cyclase|EC 2.7.7.65|Rubripirellula amarantea|TrEMBL
MMENITPLLIGIVLGIILLAVGVLIGMRWARLRSQQSGEILSENDREQMLQLLHQLGSWT
NEYSGNVSDYQNELGKLSEAVRASLNPAAGPVAENKVMMLLQQIMNSNGELQDRLEAAER
QLDKQTQQIECYLTEARTDGLTGLFNRRAFDKRLDEVFAAYRSGGRSFVLVLVDIDKFKS
INDNHGHQAGDQVLQQLASTLRTELSSAIMVARFGGEEFAAILDGPLRVAAEKMNEVRKT
IEHHPMAAGNLSLDITVSVGLSEPREDLASSPVIRRADEALYAAKNIGRNRVYYHDGRAP
ALVGAPEIARS
>A0A658Y4C8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTSVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLGANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINLLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A380B2R6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A7L4UB21|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MLADWFSEQFSTGVLIVPCMLTLAIPGVLPRFKAEQMMPAIAFIVSVIASVVIGGAGSLA
FPLPALIWCAVRYTPQVTCLLTFVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIAT
MAICPIMVSFSVAAINLLMKQVALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLL
DIDYFKSINDNYGHECGDKVLSVFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLL
MAEKIRKGVELQPFTWQQKTLYLTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKD
GRNRTSTMRYGEEVV
>A0A658Y1A0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MVNIIGKSIRPDDLLARVGGEEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQ
KVTISIGAVVTQENALNPNEIYRLADNALYEAKETGRNKVVVRDVVSFCESP
>A0A200NF93|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSVKLRLPHAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDT
IVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTTQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLHDAYKASDERLYVNK
QNKNSRS
>A0A200NPQ4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQ
MRLEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFG
HQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGVVALTAENRNRTLKLLGLQ
PVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEE
APPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAV
KEPCYSNAAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG
LFDEIQPRKNSEKLMKTLDELNQSGKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPV
AQL
>A0A837K5E2|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MDKPLWPKKFRRLFNPGRVVNICFIVVLFFSTLLIWREIRVLEEAYVANQRNNLENVAHE
MDGLLQFNLNRLLFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTLTV
YGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNNNRIFSERMSYVSRSGFYTTT
DAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPLDY
EHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTPLSPEEQ
EKLRYALANDNHGGIRQLTRYISWEKIRNFDGLLLHIHTLKEGVRGDFGTISIALTLMWL
MFTLMLIVSWLVIRRMVINMSVLQASLEWQAWHDALTRLLNRGALFERAIAAARNCRRNN
QPISVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREEDIAGRVGGEEFCIVLPN
TQLSQARAIAERIRLRIHSREILLHNSVSLRISASLGVSSSEISEEFNFEELQSIADHRL
YLAKQNGRNRVCSAG
>A0A8H9DDY6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMQAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A7Z1EG84|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDVGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A8B1NPX9|diguanylate cyclase|EC 2.7.7.65|Streptomyces auratus AGR0001|TrEMBL
MAAAHTPRESAHAAAQGVCQALGGSFAAISKWERELGKLRVLVNTGELADGEEEFPDDES
YPVHEFPEIAGFVHEQWAGGGESSAWVEAAEGPAGAPAREAREGGRGNTQRVAALRRRGR
GCCVVAPIVLHGRAWGELYVARRTGEPVFGRADADFAGVLAAVTAAGIAQTERLAEVRRL
AFTDSLTGLANRRAVDMRLDEALELHRGDEVVVSLVVCDLNGLKRVNDSRGHAVGDRLLE
RFGSVLSLCGAMLPGTLAARLGGDEFCLLAVGPPADEVVKVAGELCDRAGELDLGEGVAV
GVASTGDPIGEVRSPRRLFRLADAAQYKAKAARSGEPVVAGRHGGKDDPVVRLADAPDRR
PGPERRRFRR
>A0A0F0YZI7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MDKPLWPKKFHRLFNPGRVVNICFIVVLFFSTLLIWREIRVLEEAYVANQRNNLENVAHE
MDGLLQFNLNRLLFFRNSMQSALENPLDFAILRRAEQEYISKRHDPIWSVELNNRRTLTV
YGVSDSFVDADDLLSRNNPQASNELMATLELGYLLRLTNNNRIFSERMSYVSRSGFYTTT
DAPRSSSQVLAQFSRDTGSAWFMRQTQRDNPGRGILWQTTQQEDGYTQPQVVTASIPLDY
EHYWLGVLAMDFSIRDLQNFLVSAVKGGQMGEYQLYDKQLNLLASSAPDDVLTPLSPKEQ
EQLRYALTNDNHGGIRQLTRYISWEKIRNFDGVLLHIHTLKEGVRGDFGTISIALTLMWL
MFTLMLIVSWGVIRRMVINMSVLQASLEWQAWHDALTRLLNRGALFERAIAAARSCRRNN
QPISVIQLDLDYFKGINDKHGHQAGDRVLTLVGSTIMGQIREQDIAGRVGGEEFCIVLPN
TQLPQARAIAERIRLRIHSREILLHNSVSLRISASLGISSSETSDEFNFEELQSIADHRL
YLAKQNGRNRVCSAG
>A0A0D8I5D3|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MKALIDLIAQWWRLPDQYQSFMRYLEDRGLVSACRILVGGTAFGMGLILVLMRWSAVGPQ
GSFWRSVNLIVVAACLIAALIWWLFPPTRLWSYTFVVGSDIAIAVASFSDVDPLARLLCC
VVFASIGGYIAFFHNPTLQLGHLVFATLVTIMAGWPLLFGDNTDPGLGIAKIGVTLATVY
VIPVVSQIMLAMLSSDATTSEFDPLTGLLNRRGLSRRATDIVGEQIDEHNALLVVVIDLD
RFKEINDLHGHDIGDNTIIRTGLRIRLWTSQSALIARVGGDEFVVLERAPFNSVAKLSTR
ITTFMSGDNDVPAISSSIGIAIRTAPREVDETVDEIVSALFRVADSAMYQAKREGGNQVR
ASVV
>A0A6J5EAY2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia humisilvae|TrEMBL
MASETDRMTEQPADLPAGRGKRFVERLYRLRIVGFGLGFLCIASVLLGQQRGIVLWSLAV
FHGFIWPHVARRAALACEVPYRGERLNLMADSLFGGFWIVAMQFNVLPGVLILVMLSMDN
IAAGGVRLFIRGIGAHAAGIAVGVLVMGVKFAPMSTMTTIIACLPLLIIYPIAFGWAMYQ
VSQKLAARTREFEHLSRTDGLTKLWNRRHWEGQLAVEFERCRANGYASCLLLIDLDHFKR
INDTLGHPAGDAVLIAFADLLRRHFRAGDSIGRYGGEEFGVVLPGATLRETQAIVRELLM
RVREQAHEPGASCPCTISAGIAQLTCDMPDYHRWLLEADRSLYQAKAQGRDRIVVAGTAA
PVAAADART
>G5QYE1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Senftenberg str. A4-543|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A446ZFY9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter calcoaceticus|TrEMBL
MISKLYQSTSLHALFRKSQFTIFAITFFICSFTFVSISVFTMETYAKQNLQLLSHTLLER
IQPAVVFNDKITIEQILNEYTNDHSIRTIHIYDSEHHLIAQSFKLSSQTSILEGWFDHWF
LNEPVHLTIYHHEQNVGELTLFGSSEKILQFLKMIIVGLAIAMLFIVCALWWSVNLTYRQ
IMQAIYPLTNIAQIVSEQKAYNLRFPYNRIKEFQDLNTVFNELLEEIQIWDNQLQKENRK
LSFQAHHDQLTLLPNRHYFYQVLLDMFEDKGFDNKSALLFLDNNNFKAINDQFGHLAGDE
VLKEMANRLQTRLRHQDFIARLGGDEFAVILHSISHADHLISIAENLLESCKEPLQLNGQ
TIYFSFSVGIALSQFASSPEDFIMQADQAMYKAKNSDEHWFIYKPEN
>A0A011RJF5|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MPPSIKALNSSAAMLSASQLRKRYTMALAVIAMLTIAAQGVMQFVLADQKYDSRVVNMAG
RQRMLSQKITALSYYISTAQSGSEDTRYRRQLAEALNLWERTHAGLLRGDSELGLPGRNS
EAVENLFGPLHAHHEAIAAAARAILSAPESVATLARNIDTIRQHEADFLAGMSAIVTLYD
REANAKVVFARWLEIALMSTTLLVLVLSAAFICAPATRRIQRDMTELAAREEDLERLFSA
SPTAFLLVLGEKLTILHANQKAMNLLGLPPDPTPGVYLAPLLAGGDEANQRFLDKLGQGE
TLNECEVRLVDAVGEVFEALVSVNAISFSGQAVMVLGITSISELKRAQQTLEHYATFDEL
TGLLNRRTGMMMLDKSMARMHRQGGRLAVCFVDLDGLKATNDDFGHAEGDWLISTVARVL
IESIRASDAAVRLGGDEFLLLLHDCDLDEGSRLLDRAEQCLQETAAAAGKPFPIAFSYGL
VLYTPENGTTADELISAADSRMYQAKLDKKRLRGAS
>A0A128F9H7|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MPSIRRLFALALTSVLFLFSSFSFAETKKLVITGSSTWQPFSFINRFGEPDGVMVDFWRL
YGVANNVDFSFELKPWSESLAFARNTPNVIHGGLGYTGDRAKSLAFSRELPLNHYNVSLF
VQKDLPFDHIHALDSAIVGTVKDSTKHAFLTSRIPEKNIRLFPTFGSLNDAAYRGEVDVF
IDDLSTALYDMRHTGNSGQFTSRQKLYSFPMHFAVNKESKAIIADVERGLTRISQEDINA
IYEKWLPQNKLHLSLPWLNKTAQYLIFISSLVLLTVGLFLYHRLLKYRTTELKNAVKALK
DSKQKLETATQNDPLTGTKTRHQFFAALSDKRFSPSPYVVAVLDIDHLKEVNESYGQDVG
DIAIKHLATQLRLQLPSQTLCARLGGGEFAVLFDLSDTSQAQRKLQQLQKTLQLSLLYID
QQVVPVKFSSGIAGYPYDGESGEKLVRIASTRMRANKKSQSNFTAGDNDDDLLAEHRWA
>A0A8F9FZ68|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MAVGLIVAAALFLYEARKIVDDGLRDEEAFAVLGAANRLLHDLENAETGQRGYLLTGDER
YLDIYRSGIEDLDDTVLLLQRVVTNDDKSVETVRRIEHAKTTKVSELARTVELARSGNRD
AAIALVQTNEGERYMTTLRTELGDLLSDWRARRAAAVRDAHDRLLYGTVALAVLAVLICG
LLIYTLFVQRRAFGKISAHSKALDRAAAHDPLTGLPNRRRLLAALDELAQSRTTAPDAER
LALLYLDIDGFKGVNDALGHSAGDSLLRRLGETLRTATRAQDMLARVGGDEFVLIVPGYA
DDAQLREQAGRLIERVQQIGLRDYGGRFPLGVSVGIATWPDRVDAVEQLLDVADAAMYTA
KQAGRSTYRFGARPGRQQGNVVTLPR
>A0A8F9CDH1|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia edwinii|TrEMBL
MPQGKLASWLVYPGRDTPLAIRAALVSTLFGTLPIFLGGVFNTIAVAAALAYRHPSPLFL
FWLFSEIAVCLARLVLLVLSHRRAEQGKPTPTDLYILLAPLWGATVGYGALISATSGDWV
AATLSFLSAAAMVGGICFRNFAAPRLVAIMIFLSLGPCCIGAVLSGEPVLLLTLVQIPFY
LFAMSVAAKKLNVMLISTMEAERENDRRARHDGLTGLLNRAGLFHAVTYELSEATHKGAG
APVFYLDLDGFKAVNDAYGHECGDKLLIQVAARLRHLAGPNALVARMGGDEFVIVDQPPY
AAEPRAFANSVIAEIEKPFHLTDDVTVRIGASIGIATVTGDGSAIDTVLESADVAMYEAK
RNKKKRELAT
>A0A0H3PM46|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O157:H7 (strain EC869)|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A735GJ51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:i:-|TrEMBL
MNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLVTQPVF
GGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNMLPAAAL
FMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVIMLYPL
LFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLLI
IDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSAI
TAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRNR
TEVAA
>A0A702BQY6|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori serovar 44:r:-|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAVADTLATLGRQGQFATAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSHPIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
HGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFARDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQEFNRPFELH
NGKQVKMTLSIGFALAWEHTSAEKLQELADRNMYQAKHRRTKRLLK
>E8XAC9|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium (strain 4/74)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A702BQV9|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori serovar 44:r:-|TrEMBL
MPHETQLDNQGWLKKLARRFGPGHVVNVCFLIVMLFSTLLTWREVIVLTEAYITSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLDFAALQSAVTQFEQRRGSRFWQLELDK
RRTLPLYGVSDQFVAQTTLLSRDNRDLTNELTATLELGYLARLAQSSAMLTRETVYVSRS
GFYLSTLPTIYGSDIISRYYQYVTQPWFTAQNQRRNPQRGVQWFTSAQPYFDEPEKVTAS
LPLDHAHYWYGVLAMDIPVASLQQFLRDAAEKDSEGEYQLYDNHLHLLASSTPEQHTEAL
NERERASLSHEIKNDTQGGLRLGTRYVSWERLDHFDGVLLRVHTLREGVQGNFGSISIAL
ALLWGLFTAMLLISWGVIRHMVSNMFVLQNSLQWQAWHDPLTRLYNRGALFEKARRLAQR
YRESRQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAGGLIGSTIRSHDIAGRVGGEEFC
IVLPGATKAQALHIAERIRQRINDKEILVTKCTTLRISASLGISSSEEYGDYDFEQLQSL
ADKRLYYAKQAGRNRICASDVAQEREKK
>A0A0J6W039|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MTSSMSAGTGFLTSLQRWWHDTGDYAWLLDFLRPRGLLPGLRATICASGVIVGIAAVCLQ
FVPLHHPAAVSHAIATALAVAGLTWAVYWALAPWPTERVSAVLFILVDLGIIVATVLHAD
PLQAMGTTTLFALPGAYIVFFHGPRMHSVHLVLAVLTIVGVGLWLGWSTQPDAIALAVSK
VAIGLVIVAGILPVLQFAFWLIRHSSVESLIDPLTALSNRRGLDNHLERIAVSSRGGELC
VIAIDLDGFKGINDRFGHQAGDEVLVRTSRRISETVRQSALVARTGGEEFVVVERSPAAA
AGVIGERIRDAIRAAAHPPVTASIGVAATAGRDGISFQDALRAADAAMYQAKREGGDRVV
IAAHTPADYEPLRPPPE
>A0A128FDL8|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MINSLNPILNLGITRCDKLQIHHLRMVNLLTCLCAGGTLLFSALFWFAFGSASAALLNGL
FAILYLISFLLIREGILWMAKYWIFVTFFLQQLFLPLFVLSANFETELLLLVVPTAVMLV
FDPNERLPRYGLSLIAIFLLFLAKTVPSTDPVLALTDTDARAAYLCVILILVLASVALTD
FYLVDLHNIDESSRKLMHEDLLTETANSQSLYNQADELFYQAQRRGEPLSIIAIDLDDFR
QINEMHGRPTGDQVLVHIADLLREQLPPATPIGRLYADSFAVLLRNTPSNEAVRVAEQLK
LVIGRSVVLLDNTAVKRTASLGVTTSNEGCLAGFQLIDTAISAVSNAKKRGKNKIQTLSP
KGRNALYRNEHYQPS
>A0A840BUC0|diguanylate cyclase|EC 2.7.7.65|Chelatococcus caeni|TrEMBL
MSARILVVDDTPTNVKLLEARLTAEYFEVLTASSGPQALALCAENLCDIILLDVMMPGMD
GLEVCRRLKHDPATAHIPVVMVTALDEPSDRLRGLEAGADDFLTKPVDDLALIARVRSLV
RLKTLTDELRNRVLASRGLGIVDDPLAGATLETGRDAQVLVVEDRPETAARMQAALAVDH
AVCVVETPAEALARVAEEDFDVFIVSLGLAGADGLRLCSNLRAMERSRNAVVLMVADESQ
RPAILRGLDIGVHDYLLRPVEHSELVARVRTQVRRKRYADSLRASVQASLALAVLDPLTG
LYNRRYLDGKLRTTFTQARESGDSLSLLLLDIDRFKLINDGFGHDVGDEVLREFARRVQT
HTRGIDTVCRFGGEEIVVIVPGTPLEAAEAVAERVRMRVEGEPFVVQRGRVALDVTVSIG
VASLLPGDGSIQALFKRADMALYRAKAAGRNRVVAAAGEAAAWGA
>A0A0J6VBL8|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MHGESRGPLHARLVVDEAGTVVAADPAVVPMLGDRAVPGADLRDVLDGNTAAEVLDYLGG
RHRHAAVFDTGGLRIVVRPAKGGDRYDVEVENVDVQQARLRRLHLTEATIERVTDMIIWL
DRDGRYVFVNAAACSLLGYTADELSRLRVVDVDPFFDDEIWREHWRDIVERKSFVIETVN
TTKDGTDIPIEVTVNYVDFDGEEYNCSIVRDITERKVVESRLLALNEEITRLSITDDLTG
IANRRRFDAVLADFVDNHAVTGDPLSIIMIDIDHFKVFNDHLGHSAGDECLRQVASVLDR
IAAARGGLAARYGGEEFLCLLPRADEAAAAEVARQCQTAVAELEIAHPASMTAAAVTVSA
GVLTCRRPFDIARILTGVDAQLYRAKREGRNRVVHGPDTGSAAPST
>N9ADJ6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri CIP 107287|TrEMBL
MDMLAGQWQHICQNYSSDDLVHAFQFIQDNALILVEEFYKNMLVEKESAEFFSDDLIQQR
LRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERKIFELL
EEDDQLLTLTICSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAVQKDKQ
RSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIERIHQV
DTLNQIILECQDKIKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLLNRRYL
NTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYSQGSDY
AFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGMQFKFTVSIGCVIYDGHP
DYQKFLDTADTALYAAKNTGRNRVYLAKNNPDARVLNTPSLT
>A0A1A8TMB3|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MWDEKPKQALKWMQKAVPLMLQLDISPTPYNYGIWYEYVSNRNKALNQLVDETLRKLGNI
PSFLSRDLFHEFVLPNEFHQNNKNQKSVEQVANQLEMSSIKMGDNLSDLNAVISKSRTAL
KHSDSPHQLNKVIAYLDRGSRKALEASQKFQSDLLTAQKDIQQLKLELETLKKSLDIDPL
TKLENKTALERHLYEHLPEAEDDISLLILDIDFLGRINKDYGQRAGTSLIRYVAALLETL
QLEQSHIARLEGGTFGIMLYKSTSEEAHNHAEHLRHEISQQKIRHKQSKETIPQVTVSIG
VATLVGKESIESLFTRATTQLKRAKQQGKNCFCFL
>B2TYM7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)|TrEMBL
MINNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGD
EFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQE
LADHNMYQAKHQRAEKLVR
>A0A564FTZ3|diguanylate cyclase|EC 2.7.7.65|Methylobacterium dankookense|TrEMBL
MDVLPDLQTLRLCSLLASTAFGLVFLAFWQGRRAEPFWLYWAGSSLLYAALMLGFARVEH
VALIALFYALLAGTNILILAGVRAFDGRPAFRAWMLLPILATGLGCGLPAWLVPDPALAG
TVSRIGGTALLASSSALAGATLAFGPQVQPSRGRRIAGLAILGYQPSYILAIVAEAAGWS
EPNMAALLPMLSDQVLLGIMSLGLLAMPGERAQGALREAALRDALTGAWNRAGLAARCGL
PAPGAAVILIDVDHFKAINDRRGHAAGDAVLVTLVARIAALLPGPADIVARLGGDEFAVV
LHGTTLAAARGLAGEIRLAARRAGEAPAWTVSLGVAPAEGADLAGALARADAALYAAKAA
GRDRAA
>A0A238DRY4|diguanylate cyclase|EC 2.7.7.65|Thiomonas sp. X19|TrEMBL
MPAASEHRFRRLTLGLYACVLGLLLAGMGWYLASTWREQLHQTRDQLHALTQLTHQAVQI
QFDQYARNLDLLASQLQDGHERDLGLVRRRLIQFAQSDRGIAVLNVVGADGQIVASTALA
TGAAKPNLNANPVLRGFLEQARAHPRALQLFHPIVSPLVHSLVIPFALAGPTQNGSLFYL
VGGIDMGRQVQLYHALLTPRQRAAGEVIGVLGRGGYLFGAWPIPGPNAGPPGAQGNLDNF
LLRPRNGALQQDLLKHPEALRGDVDGLINIGLANTEYLGAFQRLAHFPLYAFVFAPKPLV
WQNWWHLTLAPLIGAAIGIAMLTLIMGLSLRLQRQWFLDTQRKNEQLRSAYQAESRQSTA
LGLLGQTLVMTMRAPDAHAILQGLCALATEQLGCALVWVGRAAVDAPRRVSVLASAGHTA
YLDDIEIALDDPQTGQGPFAHCINSRQPVFLGIDTPAFHPWRDRARAYGIQDILALPLPM
GTGQIDHAVLVYGTRPGFFTDAHVVGTLRQMVQEVALALQSLLARQALERARHAESAANA
RYHQIFSNLPAGVIVFNAEGRVQYCSAAFIGLYNLDVDPQTFVGRPWREIWAQIAELHVN
PEQTTQRIKAQMFHNQAVEDEIRLRNGRVLLGSYVPLHDQGQPHGALWSLQDITSLKTQE
AQIKKLINQDPLTGLANRRAFDTRLAQCLYALASSQQLVVGILDLDYFKNINDRLGHQVG
DELLIEVSRRLGQVLRDTDLLARLGGDEFGLILPDCPSLDHLGDIAQRLLDAVEPPMQLN
GHTESISLSLGFAVQLDGVIDGPTLLRQADIAMYAAKADGRRQYRIFGEAMEAQVARRES
LLQWVGRALREHRLELHYQPILSFTTDAKGLLVASVRKAEALLRLRDELGTLHAAGAFEE
VLDDPQLAVHIGRYVLHEAVSRALQWRAEGQRLQVCINISPRHFLDRGFLEDVKQALRAV
PAGIRDLIELELTEHGSQLNGQQARDVVKACRSLGVCVSLDDFGTGSASLTHLQLLDVST
VKIDRRFTRDLFSSDADLSITYGMLRTAQMMGLNVVAEGVESSRQALALCVMGCLHLQGY
VIARPMSAQQLHAWLGQWREALPWIDQIEGGLQVDDAAIQAIVTHSIGIRNLVQQTIGDQ
DRDFYLQPNAHELCLLGTWCTRQAERYQGGSPFAALLSSHAAFHDLARHGMTEPGIVDPT
ALGAASQRMRQAFWDVLLGCKATEADQQA
>A0A1A8T4T5|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MQRHAEEIMELHWLFDMLNHIDLGLVVINKQYQITLWNSFMENHSGKSSTAAKGQDFFEL
FPSIDKAWLKRKIDNVFGLRTSVFISWEQCPHLFPFKSYRPITGLAEKMYQNITLRPLTN
ADGTLEHACIAVYDVTDAASNRVALSSANRQLELLSKIDPLTELNNRSGLEKALELTFSS
FLKKGTGPHSLVMIDLDRFKDVNDQHGHLVGDQVLKEIAAEMIASTRRGDFVARYGGEEF
IMLLPNTDQQSAKSFCEKLRERIATRVFETKSASLKVTISLGIAELNEKDGSAFAWLNRA
DQALYQSKKAGRNQSTISA
>A0A1A8T3K1|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MKLINQRLQQLHLTQMEDLLEHAPIAIGRYNILSGRINFLNRSFTTLFGYTLHDLPNLDV
WSQKANPSKLPIRQPEQSIDDVENKVTCKDGTVRYVSFSFTDFGDERFWYFYDLSEHYIK
EQRLQARSDMLEMVAKSSALNKTLFVIIKQIEKEMPGALCSILLFDAANQTLNLGAASNL
TDDYNMAINGIKIGPNIGSCGTAAYLNERVIVADIATHPYWENFTELAQKAGLHSCWSDP
IHSANGELLGTFAIYNNINLTPNKHDLELINFASNLASIAIENHNTHEELERRAYNDYLT
DLANRRSFFELSTRALQQAKQAKESYALLMMDVDHFKRINDIYGHDSGDQVLQILAKTSQ
TAIPKNAILGRIGGEEFAIFLPNSHHKQAIQVAEQLRTTLSHMEIKSQKGERIHYTVSLG
VSSCQDKCNTIGELLSEADKALYKAKQTGRNKVCVFSED
>A0A5Q9LBY2|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MNRPSASSTLRTPLFFIVSILALFCLINFTTTYINTITTPAPLLFYGMTLIILIFYFLIS
ITIALKYLSDKRCLFLIPVACAFIGSAIMMILALQNYSKLFYCNLNDSISYNEFLRYYFY
RNALTLTQITTAALVSRFRSHRLLASHNHIIITFACISLTLAIVLIVGFSSMHLYEPTIR
LASNIMVYMWTLLFFTTIALTRFRNIFWTGIYFYCFVYILTFSFLTTADVASENTWYKAR
LFETLGTLIFIIIIFLNAFKLYQLSNNKYENAYQNSIRDYLTQLYNRRYFYLALTKKMQR
VSVQKPLSILLCDIDHFKRINDKYGHFQGDLVIQYVAWVLQDQVRRDDIVARTGGEEFAL
LLPDVGQQQAQLIAERIRQAIISPGDVSSRVKLPESVTISIGLATTEDPKTVETELLNRA
DDALYQAKKAGRNCVVAWQKSSCTR
>A0A379YCW6|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MINIEQMALILDALPDPALILSKSGRYVAVFGGKDGRYYHDGSGLVGLYLADVLNPDKTN
YFLGIIEQALASRALLIEEYELSNKDVKGLPDAGPDQPIWFEGRIQALDFLVNDEPVVLW
VASNISKRHELELQLRQLSDTDQLTGLYNRRRLERDLTVQFDTFQRHRTPTSILILDLDH
LKSINDQLGHHAGDKIIIAVAETCRTQFRKTDSAYRFGGDEFVIALPGVEQSQAVKFAEY
LCDCFYSALQQHAVNGLFATVSIGVASIEALDTSYEDTLKRADAALYQAKRNGKNRVISN
TA
>A0A7L6YT80|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C16|TrEMBL
MDKDLSPTPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQRNLELTAATMT
HSLEAALVFADDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNALENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRAVRSIK
>A0A1J5PLI7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLCVIADITDRKLAEQQLIEHHDMLGAIIENFPGGVSMFDTHLRLTAHNQRFRQLLDFPD
ALLDNPELSYQDLIRFNAQRGEYGPCDVEQYVAASVTRALQFEPHKFERVRPNGVVLEIH
GQPVPGGFETIYIDITERKKIEAQVHQLAFYDPLTRLPNRRMLGDRLNQTMALSKRSARY
AAIMILDLDNFKALNDTLGHAVGDLLLQQAAKRMKACVREVDTVARLGGDEFVVLLGDLD
TDKAASTTQANSIAEKIRAALAEPYSLTIKHEGKADAVIEHQCTASIGVVVFIDNEGSPE
DFLKWADSAMYRAKDAGSNLIRFFDLNA
>A0A1J5RKA8|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MEPVFAATTTAFIERLDAAIGAHMDWTRHILRCAVLRTRPGDDVMQADAHRRCAFGRWFA
DERAAFALLDPQRSAEVEREHRAMHDAIRRICEAVDTVQGGSESDLDAFETHQHALLRLL
SELKTQVLTTAARRDPLTGLPMRYGIEQEFDLCRRDARRRGEGLYAVMIDIDHFKQINDR
HGHPTGDAVLQRFAAVLRAATRDDEPLYRFGGEEFLLLLRAPDVDAARAALSRVLDAVRS
ARFEHGAASLSITATIGAAEVTDGADMASSVEAADAALYQGKREGRDRVRLVLR
>A0A1V5KIL6|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin467|TrEMBL
MKKWTAAIALCLMVARFSGALAEAGAEPARPTAGALAAGALMVAALALSLGFGARSRAKL
KKAVAELETFTALQDAFLDASEHMVYLKDENLNYAFINRAVERFYNRPAADILGRGDFDL
STGEFASMRRKTDLAAMRGGGAIRDEILWNGQSLSSVKFPVRIPGGKTGIGAIIKDVTAE
RAEEKRRERMYHRHKILADALSRSFASTREQLDFVLNEALELTGSVYGYIYLYDDRTQLF
TLNSWTRSVVRDCAVKNPKSTYQLESSGFWGEVVRTKQPVMLNDFEAPHPLKKGFPPGHV
PIRRFMSVPVLSDGRIVAVVGMANKAEEYDELDVYELSLLMNGVWNAIKRREVEEQIEYL
SFHDALTGLYNRRFFNEELLRLDTARNLPLSIVMGDVNGLKLTNDIFGHAAGDMLLERIA
QVFRRVCRADDIVARWGGDEFVLLLPRTAPGDAKEIVRRIKAEFSKERIKSVRGSISMGV
ATKDSPRVDIAQVLGSAEEAMYTNKAVEQGEARSFTVGEIIKTLHAESPREVAHSENVSE
LCQALGRELNLMPEELRALKDAGYLHDIGKIALDRELLSAGPDATERELREVRRHPIVGF
RILTAFDDTVDLAPAVLAHQERWDGCGYPKGLRGEEIPLSARIIAVSETYERRAHDGGNT
EEAREEAIRFVLREAGSRFDPRIAEAFANMMRNTKK
>A0A5I4KI56|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Aberdeen|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1J5RL99|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MELSDLQARNTQILALLRASRKPLPSPSAVALELMRQVGRRETGVFEVCRCARKDPMLVA
KTVQVANSALYAGLRQTAAVEDAVMRIGVAALARLAVGLTLVHTASDWLPDFDLNRHWRC
ALARGLVMQRLARRLRSIPSSEAFTLGLLSDIGQLAMAAAFGADVATPHAAEGANLLQYQ
RERWGFDQNQASAALLEGWEFPAALWLAVLPIGQEVAHAAGRGGELALMVDVARCVAGSL
CGLHAKADLPGLYMGAARLGMDQEAVVVMLDQMRTDFPDMARTLDVSIPADQAAAEFERL
RAALVVAPPLDDRLPDSALVVGPLAQPGSGLCRVLEQDGMRVLAAPGLEQGTELLRLHQP
QVLILESEPLTGDELAWCRQVRQEFGPRLYMLLLTAAPEGEETLRAIDAGANDVLAHPSE
PRLLLAKVKLGGHTVRLLAALEHERHNAFGMQRELARINANLRAAAYTDELTGLPNRRAL
HEFLAQAWADAARAGLALSCVMLDLDHFKAINDSHGHDVGDRVLCAVTRTLHAQTRSTDM
LARWGGEELVLVCTNTDARAAAALAERMRRAVADMQGDFPAVTLSAGVAQAGFSGARIED
VLHAADQALLLAKRGGRNRVVSLPMQVQGCAEPAD
>A0A1J5RBM1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFRFIAGFFPRFATTSWLSCLLCIVPVACAASPLGLEGGWYQAPADWVYDGRHIPDNARL
QPVDFVSHTGGRFIFEADLPIDQPGTQVLDFKNSSVIGVFHHWIFDSEGRQVGSAEGGIE
SAEENPFLLRHGREFHLPPGRYRLITEVSAPFFLAHPQPYIDSLEHYRQAIKPGNALVFL
CLGILLGLAIYYSVLALVRRNVVDGMYALFILGNLLYNGTALLVYPDLFGVHWFYLISMP
ILFSNCAYAMFVITLLDIRRKGNPRLYRSGMWLLALLGAFIPLALFKPHWSLELDRYGVG
LFLLFGLVSGIVRARQGETTARLYLVAIITFCLLGFTSIALGRLPGVFTFYMEHIGLVAV
TVEALLLALVVAQLFAQMHRERERALTQARRNRKLAQTDALTGLPNRYALELALAQLPVQ
GSLTFIDLNGLKHYNDRFGHERGDQLLCSFSRNLESLLPEHASLHRLGGDEFAVTSNTGN
VSQIEARITDTLKVLHAEGFELAGVSFGSVRVAENPAKDKLMRMADERMYERKRRGKMQQ
RPDGDQGPIATS
>A0A1J5RED1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSALAAELTVDPSASLLTPHPLAAAREAGGAVGAIRAARRVLTAWLQRCLRQGAYRQQAQ
AVAALPLAAIERQLHVALAEAGDGGIEPTHAELIAELQGIQRLVARLAGTQKSQPDALRA
YDALVDSSLSALHHLSELEVELTAQQAWLDPLTGLPGRRALQQRLLAEHSRVRRHGGSCA
LALVDLDRFKPINDRYGHLAGDSFLVAFAAALRRLLRPYDSAFRYGGDEFVLVLPQSGQG
EAEAAIARIQQDLGEQPLLQLRGQPVHAAFSAGIALLEPARSVVQSVADADARLYAAKAG
AARADR
>A0A1J5PZB5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MEKLARISDHYQNSLRELTESLKEASLHDPLTGLGNRRFLVDHLTQETERANRKNAPYVL
GILDVDYFKTVNDRFGHEAGDTALCAIARAMEAALREYDLCGRWGGEEFLIMLPETPLDF
ALQIAQRVRLGIKKIQFDFMDTPISASFGLTIFRSGEPFSETLSRADAALLQAKAAGRDR
VEFA
>A0A1J5RNH7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPPRTLLVDADPAALTSLAHPGGDWWAALEAAGDGAWAWDLDSGLMACSRCWLQDCGFAG
EDRGAAGLLWRERIHPDDREAVAAEIAAFCAGERDTFRSEHRLAAAGGYRPVLMRGAVLR
RSAAGLPAVLAGTFTDLSGYRRLEETVRQLSASDPLTGLRTRRAFLEAAEGERRRVRRHG
GALSLILADLDGFRRFNDAFGPQTGDAALCRVARCLEATLRKTDTVGRLGGGEFAVLLPA
TEGARAGMVAESLRQAIADSSVPGPGGGSVRITASFGVACLAAQEDGVAELLRRTGAALC
DAKRLGRNRVCRPAP
>A0A653DTT3|diguanylate cyclase|EC 2.7.7.65|Callosobruchus maculatus|TrEMBL
METYLQTVKQEWVKLINETDPEVHRLAAELAGNNATALIDEFYRIVLADPSVAEFLTTEQ
VERQLQEALRRWLTDVLSCKAGQVEEQIRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PIITTSPHSSEIKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLTWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDETFERIRQSEQGMNDNVHRDKFLHQMRNSLSQIITLLRELFDEVSRHEVGVDVL
TRLLNRRFLPTIFKREILHASRAGTRLSTLLIDVDKFKQINDTWGHNTGEEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIVLTEISEADTLRIAERIRKRVEKIKVNSPAGDIIPLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWKEA
>A0A449BDN5|diguanylate cyclase|EC 2.7.7.65|Haploplasma axanthum|TrEMBL
MNSLITISKIFSSFDEAIYIVDKTRKIVYFNPIAEKITGFSSNEIVGKHCFDNILNHIDS
TGKNLCINGCPLLKTINENIVVQDNVFLHHKDGHRIPVYVKTIPYIEDNILLGAVELFST
KIEREMIDKENIIKENLSMIDPLTGLLNRNFLSYRVHELISKQDSNYAVLFLDIDDFKTI
NDNYGHLVGDKVLEIVSTTILANTTNDDFVIRFGGEEIIIFLKTPNLETAFRKAEQLRIV
INASEERNIRYRPKVTIGVSMYDKKLPLNTSIELADKAMYYGKQKGKNQVSFNYWEV
>A0A728QX52|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B|TrEMBL
MSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAHSLEAAL
VFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISHWLFPLP
VSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLHNGVVDA
LQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKNAQLLRT
ALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAGDRVLIE
VAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELHNGQRIT
MTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9HYF2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O141:H4|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A1E3ANT2|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MNIRTSMYRIVFLMIALPFLLFSLITTYIYSSGLQNALIESLHVVATTHVTEMTDFCEQQ
KDYMTMIGTMDISRAAMKGSLDKDLCMYLDNMLYSRVESLSYLNTFALIDSDYRVVACSE
EHSTFANDGIDSLIKSMGDQDFFFSDILIDGQGNKTLVAIARIDEQGETLGYSLMEINLD
FYEGIRERAELWNDATFYLLDGRQQIISAGTSEEGRDNFVTSAAERKDYIKNYESIDFVK
NPQGYFQYKVGGKGYITYYSNVNYTQWRVLLTVSMDNYLSQKYVYYILAFFMISLCTILA
FRIGSFVSKRIVHPIKSISSTLTDIRESQDYSLRVSVERKDEIGRLAVEVNNLIDYIETE
SLYKAQQRRLLQQKAEQDALTKVLNKERISQYLQEALDRHCSENTEMAVLFLDIDDFKIF
NDKYGHHVGDQVLLFLTSLLTRESEGTVGRVGGDEFLVIIEKPDNVRSLDQCLRQIEEKA
GSSFVIRGSDCCLPIYCCIGAVRIDFTVMEGETLSAEKAIGLADSAMYRVKNNGKNGHLI
LEYPGSETANT
>A0A1E3AEY2|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MDNERKRHSHEYQDLFNNIPGGAFLCGQDEHCIMTEVNQGFLELTGFGREELEEQFGCSF
AAMLHPADQKDVMERMLSLAEDKDKAFVNCRIRCKDGSYKWAADSVRLVRKATGGNQLFC
IMLDVTESGNAGEELRLSLERHKIIMDQTTDIIFEWDICADTLIFSSNWAKKFGYEASYQ
GIGNGEKFPHIHPEDVETLKKQMKEVRQGTSYTTEEIRIENADGNYIWCRIRATAQYGDS
GKPLKAVGVITDIDKEKHMIDALRRRAERDALTGLYNREETEKQIRRHLKEEPEEICALF
MIDTDNFKQINDCYGHLFGDAVLSELAAGMKRLTRQSDVVGRIGGDEFTVFLKNIPSREL
GEEKARNLLSMFSNLFKDEKQTVEVTCSVGVAFYPEDGRDFQSLYHSADLALYEAKSGGK
NQYRLFHSQKGTEKEQKSYSSLGAAIDSDQRTSGAPGDLVNYVFQILYDTSDLEWSIQLV
LEIVGKRFDVSRAYIFENTDDGKYANNTYEWCNDGIEPQKEELQRVSYEGLEGYEELFRD
GSVFYCRDIRSLKPVQVALFERQGIRSTLQCAIREEEVFRGFVGFDECTGVRMWTKEEVG
MLSLISQLLTTFLQKKRSIDRERQMTIRLNTILDVQDAYIYVIEDGSYRLLYLNHKTRVL
DPSARKGMICYQAFFCRDTPCECCPLTGGNGEIYNPQYQVWTKARSASMKWGDRDAWLLT
CFDISEFKRMQ
>A0A6N3QIY0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MPVHLKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGRA
DRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A0U0ZV18|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus|TrEMBL
MQNPPYVETGYQYDLVTNALRDTGQLGRLKTGIGLLCFVIVFLQGVTQFYPLGPHGTWPR
VVHGITAASAVVAGLCWLSFSWPGRRAMAAFVVWADVALAVGAALLSDPTARICAIVYLG
PVGLLPTFFLSRRALVAHCAFATSLLGAVLAVNVLSGEARMFEQFFYAAPVISAIVLVPA
VIQLVLEGGRDSILSAALAADRDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDVDG
LKELNDTHGHGAGDMTLKAVADMLRARTRVGEIAARFGGDEFLVVAFPGRGEGIESTIRR
VSAPRAGIDYWTVSVGAAWQSRTGSKVDLESLVQQADHSLYEAKKTRGMLDPQR
>A0A1S7RKR2|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense Zutra 3/1|TrEMBL
MFTVLECVVVQHDRAVVLLAAVICLLGMFAFFHLLLRAEESPAGRKPYWVLVAAFAGGLS
VWATHFVAMLAYKGAVPIGYDFAFTALSAVLPVFGFWLALTSRSQAAYIPAIVGTLVTLS
VAVMHFVGMAGMDVAATISYRWGPVLGGFAVAWASFLLAFFLFRRLGSWQRIAAPAGSAI
FAICALHFTTMSATVLSPDPSVSGPDPDNVARLIMICAISGVTFLILSTTAAAALVDRYL
VDLKGLVDATLDGLAVVRDGRIVELNTRFAGLLGREEASLVGQNPDDLFKAIDGQPAYLP
RHAPVEAVRERAGQAQIFELGVRTIEYRGRPCEVMAIRDLTEKREAQREIEYLARHDVLT
GLSNRTMFQTRLHQQIEHCDGEDEFALLALDLDRFKAVNDIFGHAEGDRVLKKVAAILDE
CARAGDVVARLGGDEFVILTARHTKAEEARLLAETILGMFALKMNVANDPTSVGVSIGIA
VFPRDGKDHESIMHAADLALYRAKMGGRGILAFYDPVMDQEARERRQLETDLRLAINRNE
LLLNYQPVLSVECGQVVGYEALVRWQHPTRGVVPPDVFIPIAEESGIIISLGEWVLREAC
RQAAGWAPHLKIAVNVSPLQFSLANLGHVVCTVLMQTGLSPNRLELEITEAALLKDRKAT
LIILNQLKALGVAIVMDDFGTGYSSLSNLQSFPFDKIKIDRSFIAAMSDDDNARAIVRAV
IGLGRSLDLPVTAEGIETDAQYRMVVDEGCAQAQGYLFGKPDVAPAQVVSATTRKKHSV
>A0A1S7S1C8|diguanylate cyclase|EC 2.7.7.65|Agrobacterium deltaense Zutra 3/1|TrEMBL
MALLLIAQFIAFSLFPLYFTTLPAPSRRTHFYTYIALILLIGGFMGNVYSLPIADGVVVS
GGNLCYGAFMMASVMFVWVERDAFILRHLVRLVVLVDIFNIVFSLLTHSILETDGVINPH
AVPSGLFEISTPMIALGGVLIISELLLLLFIFEAVKKKQSSLFVTAAIYILSFVLVLVLD
GIAFPFIAFGINAQIVAIVIGGLAGKILIAFAYGMPLALFVLWKRQAFIHYLETDTVRWR
LLASSSADLIKEMTIKDQDVRRGDIVFKNSTEGLAIVNHLGQVLKANAAFRAMLGINYDH
TGQHDTDIDKSFWIDGRPVSRPHGAAGQWRQEVMFGADRHRPGILSITPAGEDASGGDTF
VYSLTDITDQKTAQAKLEYLASHDHLTGLPNRRTLDKSRARFQNVPHALIIIDLDYFGDV
NDSYGHGVGDRVLQLIAERLDNLRENYLASGDVLCRLGGDEFAFLIQSGDHGFIEGIIEK
IQSCLGQTVHIRDDLEVLSSATIGVSYHLRPGDHDTLLGADAALYEAKRSRRGSVGVYED
RLTAQSQKRVKLGLKLKNAIANSELDVYYQPQFTAVGHELHGVEALVRWSDPELGVVSPA
DFIPVVEETGLIETLGEYVLERACRDGQEWLQAGYLPVTLSVNISASQLRFGRFIPFLKG
VLSETGFPARQLEIEITESTYIQRENEVSPLLNELREMGVGIAIDDFGTGYSCLSYLAEF
PCSCIKIDRSFITDIPTDTRQCSLTSAIISLAKGMSFKVVVEGVETREQLDFLTKHECDL
IQGFYFSGALPKAELAALLKPAHTSIV
>A0A6N2YV27|diguanylate cyclase|EC 2.7.7.65|Eubacterium limosum|TrEMBL
MDTFLIFNLIGNISLWLLIIALIVTAFFYYNYRLKKENLEQKEQYRLDVDLIRTMLNMVS
DCVILLDESGKILRVNKKLEEYYGRSADKIVGKNYQRFHTDFDYEEHKSNMRLNFDLGST
YTLPVKYYMPDRSVIPFSVEIHRFVFSEKVYYGIVARDEKNLQEREAYIEEQASKLVEIE
HIARMGYWELNHQSKEIVWSRELYHILGYEINTVKPNLDILFKMVHPADQERVTKAFLDA
FQNQETVDIHHRIITTKNEVVDVLIRIRHTFSSKNEHLSTIGIVQNITEEKELRDNLDFQ
NQFSKAVVDNSDMLVLTTDESNNILEVNPFIEELTGQSREVLIGQPAEAIFGHVAQRRTN
KDRNYRKPLDLRDKEGRIRWIYWNTRELPYFDNRRVCVSVGLDVSEGVEYRNKFEYLAYH
EPITGLASRLKLRQVLSRYFAKNAGKPGKHIALLNISLTNYHEINDLYGYEVGDQVVKQV
CEQLSDRVGHYGLLARHSDDLVVLFLPNRNAREKIEPICIEIIECLNEPCVVEGMTFTIG
GQIGIAKYPENAQNKEDLQRFADAAMNCARLDTSIDYYFFDDKLRRKMVDDKMMYRKNYK
K
>A0A2H6B437|diguanylate cyclase|EC 2.7.7.65|bacterium HR40|TrEMBL
MSGPHPSPPSEPSESPAAVLARRIRQLELAGRIAGIGFWDYDFTTGRFWWSEEIWRIAGL
EPDAFRLDAESRLAIFHPEDREARRRAWAEAIAAKRDFDHRARVIRPDGSIRHVETRGLC
RLDERGEVAGYFGILQDITERIENERRLEEAIRQAEADRALLQTATEVLFDGFALFDPED
RLVLCNRAFAALYGEEPEALAGRSFEELQRLPAFRHRFGLAHLDETAFARWLAERLQRHR
EASGIPREVRGGDLCFWVQERRLRDGSIVLCRTDITALKRTEENLRSLAQAFARARHAAE
AAHALLRAATDVLSDGFALFGPDDRLRLCNHAFAALEGTTPQALEGRCFAELARSHLDRH
RPGLDPEARARELAARLALHARADGTPFDLAVGERHYVVREHRLPDGHTVLLQTEVTHLK
QIERDLRRLATIDELTELANRRQFFDRGRRLLERARRHDQRVALLLFDLDHFKQINDSHG
HAAGDLVLRRVADICRSTLRSHDLVARLGGEEFAVLLIDTDREEALAVAERLRTAIATAD
IRYGEHRLAVTISVGIAVPEAGREDLEACLAAADRALYRAKHEGRNRVCAVVHEGSAGGG
SGPSRHERRR
>A0A1V4Y1W3|diguanylate cyclase|EC 2.7.7.65|Syntrophus sp. PtaB.Bin138|TrEMBL
MKPGNGGARTAVTVSATVSEDGKECLAILADITELKKKEEALREELQHHRALFENARVAI
SQVDEGGTFLRANKRFEALTGYTQEELKGMNIREIMHPDGAGQVKEMIAGQVRGEIAPIF
LEEYYVCKDGSRKWGEIRSRAIRDGGGGFLSAVVAIVDRTRGKQMEKALADNESLGRSFF
ENASIAMFHSTLEPNRLLRVNSAYSRLLGYESPEDLMSASAGMDPFPEEAWDRKAFFAAM
EQRNWYDGDYPLIRRDGGILIGKAAIRSVFKPDGSIDHLEGIVENITERKRAEEVLQKRD
RELQEKTKSLEEVDAALKVLLKNLEKNQEELTERFLINIREQVLPCLVKLKKTPLNQAQR
ALINSAEAYLDEIASPFVQKLTSSYLNLTKKEVQIAVLVRDGKTSKEIAEIVNVSKSDVD
FHRGKLREKLGLKNQKGSLTVLLRTLSHEGPRERP
>A0A2S6Q7U1|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
MKKITCVLGSACLEVVSTATGQYTNNRFTGFTNVSFGGEGYYVSTLLNALDSSACLLSAI
NHNPVSQLMADDLARNKVRSHFLIDDGLPDSVANYHYTDGQLASVVLTNPNTMAVFSEDF
VSRALKKAFSFFLDLNPSIMSFENIATAINKKPDLKLFISACDSLDIDKMNMICERSDLI
FLSEDTLKSGKTHYDCESLRELTNRLQTDLVIILDDGNILISDYEEQVITNLKESLKIGF
RHKVLRDKNFFKACLVDALNNNADLRILQAAELVLFNYDELSWRIDVQIEKQNPLESSMR
TVIRKAHRDNLTGVLNRHGLDQFLTTPGIDLSTYTMLMIDIDKFKGVNDTYGHQVGDEVL
TGIASILSDHMRQGDIAARLGGEEFICLIKNLTPELTETVANRIRSEIEKTPLSTEHLNI
TVSIGCTQWQKNEMFIDVMDRADQQLYKAKHSGRNKVIVG
>A0A5I4U4Q6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Adelaide|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5B1CBJ5|diguanylate cyclase|EC 2.7.7.65|Rubripirellula obstinata|TrEMBL
MLQKYFASIRLAFALVCVGASLILAAQWLGFVPDAAKLEMRARRDLSETIAITATHQIRN
KQWIDLQRNLQAIVDHHPTLLSIGVRSNMGTLRVDAGHHAGIWPEVISMDDLSLKNPEKL
VINEQKSVGVETAFVPIHLNRRPWGRIEYCFHQPITSTLGQALAQPLLRLVSFFIVAGLF
SYTLFVARMLGVFSSTQVVPDRVRQALDTLAEGLLVLDESGKIVLANQAFAAIVGKPAEE
LESKLADDLDWIQEDLDQNGASPWSLAIEKSILQSECMLRYELEDGTERIFSVNAAPLGK
GKSGRGALATFRDVTHVEEHRIELERMLNLLEHSRDEINRKNEELQILATRDSLTGCLNR
RAFFEEFETIWEDAKNEGKYLSCIMIDIDHFKSVNDTYGHHIGDEVLREVSRVVRELFQE
FGLVCRYGGEEFCVLLPEHHSEQAVMQSEKIRAAIGKVRLEDPAELRLTASLGVSELRFN
ATEPQDLINQADACLYVAKRGGRNQTVLFNSSMVVEEDAAPEETITVSRVEIPYKAVTAL
MSALSFRDTKTAEHSRRVSDLCARASEGLMDISDRYVLEVAGLLHDIGKIGVPDHILFKP
GALTPEEWEIMGRHDDIGVEIVTGGFDCPELSSIMANHHAFFDGKGRETDLPTGHDIPVG
ARLLSIADSYDAMVSDRPYRKGRSHAEAITELRDCAGTQFDPELVEHFIKKIDAAMPETA
SGAMAIRKLAAIEIGSQIELLATAITASDVNQIQELSDSLTSMADSIGLSSISEAASHLS
GRDHELVTSTELLREARDLVDTCRSTQSNFLRLSLESQADQTETPKVDR
>A0A857JNS3|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MNIFRTLHRSILLLFVVVVVSIVTLVHFSVSKIVAEQSRAQQQSHSPAVELIVEQLMKPL
HISETLVKAKELQDLMGAHTIDEQAVFSSLKRLHREFGMNFFIASEKSRRQYYSDGTTTE
LIEGDVSWYFKYKNSAQNEIADIGKWEDTHFYIDLKVFDENQRFLGFFGVGKSLRSFLDI
FARYKDTYGYDFIFADQDKNITLSSDPKLVAANSQFTNLADLPWFKDLSEEQQQGSLNNL
LVKINGFDFLVAELNIQPFDWTLYLMTPLESRQTEISRGFIFSVVTLLVLIFGLFLIIYN
LLYYFKKDMQKTRQIDVLTELPNRASMSLKFDGLMYEKTSVSLVLINLDNFKSVNETHGR
KAGDIVLRQIASMLQLELRDQDILGRWGGEEFLLLLPNTGPHEAVEVAETVRNRLANMTI
TTGSMSIQMTASFGVSFTAIPRAINEVIAAADDALFAAKREGRNVVRLQLIEEH
>A0A379ISI6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MSSTTRRGTQRSLQSLLLKRFAMAFATYAMMALVCWFAVFNGLFLGSISTAVWLSLGVFG
SQLVFLWLFLSGRNLRYEDPSLTEAQVLVALAWQPPVLALFDSARGVMMVFYVLILLFGV
FQLPPRVFARCAAFGFFGFTAMVLVEAYRMQLVDPSMAWLQVWVLFILLVWLCLFSSYVQ
AMRKRMRQRRFALQAHQDTLRGMMRQLEELVATDELTGLFNRRHFLRLASRELEHLGHGR
QHGLALIDLDHFKRINDAHGHAAGDRVLQTFAAVARACLRDGDIVARYGGEEFVLLLPNT
DADQFTACCERLREAFAKAEPVGVKLETLSLSAGMTLLVAGDDLDEALQRADQALYQAKR
GGRNRCDASWERAGA
>A0A3S4UXH9|diguanylate cyclase|EC 2.7.7.65|Aeromonas encheleia|TrEMBL
MSKDSFAQSAAYLKQAVPLMIKYQIPTTPNNYHLWYNYVSGDMPELNSAIDQAVKLQGTC
SLTTCERLYHQHLASQDEQQMEAMKLNLAAMANELGHSMQDALVDTGQFQAMLDKSFDRL
SLIDDEGLSLEDTMGILRELVRESRDVRMSTMHFRSQLSSAEKEIKELKEALSETRKLAT
EDALTNLLNRRAFDLEMECLIRTRQPFSLILVDIDRFKSFNDEYGHLLGDQVLRIFGKRL
REASKEGITAYRLGGEEFALLAPRRSLALTRQMAESLRRAIEKMSILDRKSGRRIDHITA
SFGVGEHQGQETGDALVERTDKLLYKAKELGRNRVMPLPS
>A0A379IW83|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MVARHNAALARAPETEQLTAILRLLMLLLLPALSWADSLPLPIGQTQILPGPYLSFWEDP
SGEASFSDIRALPDSAWQAVDRRDASFGYSGSAYWLRLDVHNPHSRSLGWVLLVGNPLLD
YLDAYGLDGERVYRAGDQRPFSWRWVEHRQLALPLHVEAGEQRRIWLRMQTAGSANLSAS
LMTHEAFDHQEQSGLLLQGLFFGALIAMLIYNLTIFCITRDRNYLWYSLFVGSFSLYQFI
QLGFALQWLWPNALTWHQLSFPLSSALATLFGIHFTYSVLELDEAAKPYRWTTHTLKACA
WLVLGMALFGPYAPALIGSFVLVIACAVAAFIITLLRWRSGYAAARLFALGWFVLITASL
ASILTGTGLLPYSLLTLHAQQVGGLIEMTVFSIALAARIRQAQQAERQAQAKLIDQERRL
RNEQAKHLELQTQISESLEQRVQERTATLRDTLQQLSNANLRLAELNRRDGLTGLFNRQT
LSEELARACARAERSRQSLAILMMDLDHFKQVNDRHGHLAGDACLRHAAQRIQQRLRSSD
LLARFGGEEFVALLDSTDLTGALDLAEQLREDIARTPCSYQQQSIPLSLSIGLHAGVPSD
PCCGEHWLELADRALYRAKSDGRNRVVSYEARAFNDL
>A0A6N2SQU8|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MWGRLKQFLGVIPDFTDSEEVIRALHGDVVKRNFLFHIFVIMFECVMVISISMRPGGPFA
KPRRVTYFVLYLVLILAAAGVTWLEAWIDRKRQADFRLYFRAEAAFLAFFSLWGVAVTLN
DQLGGNGLTVYNYVVLILAIMSMMKPWQAAFLFLADFILLNGLLPCFPDPAGLDNSFNNL
MNSLFSTLAAAAIAASLYNSKLQAKRNEIIIRRQYRQIEAANQMLSQEALSDALTNLGNR
NRFEKTIQAFEFDKQGCGTLGCIYIDVNGLHEINNHLGHQAGDRMLKTISDIFLEYFDSQ
DIFRIGGDEFVILCKNMGRQEMVRRIEQVCRKTEEAGFSLSTGLEWRESDLGIEDVVQKA
ERAMQENKKGFYSSKGGERQRRELNQHMERLISEKKDADRFLSILAPVFEGVFFVNLETD
TVRQIFIPSYFQEMLKECGDKYSKALLLYADRMVEPQYASLFELCCDYSRLEAMLEGEEI
PDFTYRKKDGRQLRLRILKFYHYDSTGKETLWIFSDIEINYIES
>A0A379IRQ6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MLMLQLHLPTLLVASTAVISLCGVLLIFSWSQGRQQRALLWTGAMMLLAALGLVLNALRG
GSFDWVPIVLGNIVLLLCIAMTWSVMRVFCGRAPSYPWVCAGAACWALLCLWPTFYASLA
ARVAVHTLIASLYLLAALVELWRARLRLEVSVVPMAVLVSLHLIFLLARMFLGPGMTGYG
DIQSNPLFTLVLIESMLYAVGIAFMLLSMVKERAEKQFRQAAYSDELTGVGNRRAFFEAG
ERLLSLCQRQRRPVALLSFDLDHFKAINDELGHQEGDRVLKAFASGVAQSLRRSDVFGRI
GGEEFACLIDGNATDALALAERIRVGFSALAPKGREQSVSIGLVAVEWGTYDLQYLLNLA
DKALYQAKRDGRNRVEIYQSDAGGSVGGAEVG
>V1A381|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 908573|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGGIRMSSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTQAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVFASDNA
>A0A7W2X5E3|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. RHBSTW-00465|TrEMBL
MNKDLSQAPRPTFKKALRRISMISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSSAAEDTLATLGRQGQFSKAVVLDNQQKHFAAWHNNHLVNQEKISGVIS
KWLFPEPTVQPIWHQGKIIGELRLTALDKLISHFLGVSIIVLTGSIFLASCIALLLTHSL
HRGIVTALQSITDVVHDIRKNRHFSRRVPEEHIEEFHLFAQDFNSLLGEMEDWRQQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINELMKDETVHSSSALLFLDGDNFKYINDNWGHAA
GDKVLIEVASRLMTFVGKQHQAWRLGGDEFAILLRNVRTEAEVQALCHSLSEQFLQPFNL
HNGHTARLSLSMGYALTWEHASAENLQELADQNMYRMKHRRLQHTQK
>A0A822V9V0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. B6|TrEMBL
MQAFTNEDHERALFAQNNGNYLETKLQAYKVMAASMSLSYLSMRFVQVMVMLAGAWFVVR
GDHFKAVNDNYGHAAGDEVLMSFAQRVRNCLRPGDAFGRVGGEEFAVVIPHCPKPDAIRV
SERIREALAGTPIGLSDGRLVKVTASIGLSLSPETGAISVERLLSSADAALYRAKANGRD
RVEISEFPGPVAS
>A0A0A7A4G5|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIILPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>Q3YVR1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei (strain Ss046)|TrEMBL
MAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAEA
ILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPIMVTRLFELPVQISLGVYSLERPA
NPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAR
ELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLP
NKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLVEKLKSVLSPRM
ILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDL
TAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQP
QVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQ
ERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAIL
RPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLA
QSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFAHPLPIEIFEESYLEEK
>A0A0K2GHN5|diguanylate cyclase|EC 2.7.7.65|Nitrospira moscoviensis|TrEMBL
MTDAPFTRDPSAMAASDAPRYDPRALLNSQPVIITVIDPVTHKAVFQNSSSLSKFGDISN
QSCHEKIAGCAAPCEFCKMPDAVAQQHPTASEVPLPNDEYLLVQWAPVATEEGAVHVVET
ITDITAYKRQQSQTEQLVKRLSDTNRELLHTNEQLRDQSSRDSLTGLFNHSYFQQALTQM
CARSARSARPLSLLFIDLDNFKNINDTYGHAAGDQVLKEMGWLLDSHQAARRLARAGDIA
ARYGGEEFALILPDTSMEGALSAAERVRHRVTTLLLLPELAPLAKRDLSLTCSIGVASFP
IHATNASGLVAAADAAVYVAKRSGKNCVRMATPVTPKPLVRS
>A0A2X5C7Q7|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MIGLFRRKRAAHSRPTLGQVLQRMNLSLALIAVGTAGIFLTLVALFALRAYANHNLHLIA
RSISYTVEAAVVFDDRSAAREVLMLIASNEEVSEAKILNKDGKLLAYWHHPKDGPLHGME
QLVARWVMPEAIELPINHEGKQVGKVWLRGHGGTLLRFLLRGLAGIIACLALSTLCALIL
SRRMLHGIVRSLNDIANVAHVVRSDRSFGQRVPSAPIAELHTLSKDFNGLLEELEAWQAH
LKQENDSLTHRATHDSLTGLPNRAFFEGQLSHALSHISPEEKLAVLFIDGDRFKEVNDSH
GHAAGDAVLTTIAGRIRSQLRDSDVVARMGGDEFAVLLSPVRRQSDVTHIADKIIGCMAQ
PVELPNQQQVIASLSIGIAFYPDHAATPQGLLHEADDAMYQAKHRYHGGWRLAIQK
>A0A1H2WE92|diguanylate cyclase|EC 2.7.7.65|Pseudomonas kuykendallii|TrEMBL
MTADVLAPLAADWGALIDRYDATLCRTVGALIDAHAESLAERFYQHMGDDSHAGQFLAHQ
RVEEHLKPSMRRWLQEMFALRNRSDVPELIELQKRIGEIHARVDIPISLVMRGARFLKAA
IFLQLGSARLGRAQLDAITFVSENIDIALEVMSQAYSLAHQRNARSEEAYRMFSVSQNIG
TERERQRAGLLDWENQLMYDIALGAQAGQLQPLLQSDFGLWFKHKATHAFQDAVEMSAIR
EHVDRIERCIAHFQPAEGKLRQLRELRESTRVVRYLLDTLFARAGELEVGRDSLTQMLNR
KFLSVVLNREIALARTTHSPFAVLMVDIDHFKSVNDNLGHEAGDLVLQQVAAILSQLHTR
RRLRLPLRRRGIPADPRRHHRSHRHDTRRAGAPASRRGSLPARGEPLDPHHRQPRRGPAR
RSSGLPAHPAPRRPGALPGEERRPRPGGAGLRLNVIAPRAS
>A0A2X5C8Q8|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MNARSYQELLNSKHRLAILLFLLMNIASSLFTLLMPLRNTPAITPPLFGIPLFCLAALLF
TLRSPGNYIKRLEYFSGVLGLLWAGHIYMKSQYLLPNVQNYLIISLFSIFFISAITLTDN
VIAFCLHAVPSALIILLLDNQHNTLRILFISVLPIIAFSIHHLMLKRSESFTYALVARLY
EERDKLSNLSMLDPLTGLYNRRGLENKLTLLTTPQSGLHFVLLLDIDRFKAYNDHYGHTM
GDQALVKVACAIRDAVRSRDIVVRYGGEEFLVLLTNVSKEYAAQQAEQIRLRVQALAIPH
GFNQLAATYVTLSAGISPLEQLDVDSAIRAADSALYQAKNNGRNSVRLATARP
>A0A8B3WAA7|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MPANPILLVVTLMLLASFLMLGLSSFIHIDSNYDLFFETNTLVIIMYIYYVARHAIRPHK
ALRYGALLLISNLLYDVITELKHLDEWADRNELLDTFLEDGLLQIAFLLIAYGITELTTK
LKDQSKQDELTGLYNRKKFDAITLKEFELIYFDLDGLKRVNDRKGHKVGDLMIVRFSQAL
NQAALEDEMVFRVGGDEFVATAQLGRGGEFVTQVTNLLHGENIGFSYGIEVTSRENFKQA
LDESDKAMYEMKKAQRTDQRA
>A0A5P9C5P3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MQPLGSINTTASANDERFDGMVRLICAHFAVPACVLVAGEGRTRRIWASAGLSDTQRRQI
ADAREAGPLAEIKHLRILVVWPLLACQGGQLGCLYLLDESHRLLDASQEQALQEFAWLAL
DLLEREAKDARQRHELAALRESERRMALAIAGSGTGIWDRNVSSGEIHYSSSWKALLGYA
DHEIGNRIEESYTRVHPSELDYVRATIQAHLERRTDAYEVEHRLLCRDGQYKWVCSRGKV
VERDSDGQPLRMIGTTTDITAIRRLSDQVQQTVELMTDLTNEIPGMVFQFLRPLQGEPAF
TYVSAGAQAICGLSATQLMQDAQALTTVVHPDDQDAFLDTFTRCAEQLTPWHHEFRVQVP
GREVVWCEVEACPRRQGDGSVLWHGFMTDVTERKQIEAELQAFATTDFLTQLANRRHFMR
QLEIELARLQRSSGQSAAILMFDLDYFKTINDRWGHNVGDQALRHFATILGAQLRKSDTA
GRLGGEEFAVVLGETDQQQATHFATRIQSELARTPILHAGEQIFLAVSVGISSLTANDSN
VEAALSRSDIALYCAKRGGRNRIEYH
>A0A5P9CA65|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MDALENKAMTPPRQPSDAPERVARGPRTATPLNLLVVLASVFILVVWLITLQRIAFEREQ
ALAAEMKANASLAIAFEQQVSRALKAAEQVAAFVREQYRLQGRAIDLRRWVEEGVIREEM
FTIISVVDEHGDIVSSSRSTGPVNYADREFFTAQRAARIDHLFISQPVFGRVSKRWLIPM
SLRIEHADGRFAGVVVMAISPQDVTQFFQQVDLGAQGLLELGGLDGVVRARKIGARSEFG
LSGESLAWFQRQKQRRTDDFYDSGQGLDGVARIVSYRSMADYPLMVTVATAYDEEMATAL
QRRTTYLLAAVGVSLVVMLFVGVLALMLVRQRAATDALQGSEALFRATFHQAAMGIAHIS
PEGRILRVNETFSRMLGRPPERLQGGNIFDLSDPEVASAARTFLREQLASDGGALSPEIE
KTYRREDGSLLWVCEAVSVVRKRQGHPAFLVLVAQDVTERKRLEARLSHEAQHDALTGLA
NRVRFRQRLDQALDAVRDQEQLCAVLYIDLDGFKAINDRHGHTAGDCLLQMAARRLEGCV
RSSDMVARFGGDEFGILLASLHSRQDCAAVALKVLDVLAQPFDLDGHPARISASVGAALY
PLQAYNGADLLKQADQAMYVAKHAGKNRFHCAPE
>A0A2G4B4C3|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MNKLSLDRKMPLYVVSTLALNMAVSLWLLSMASSAVMAFSVCALFLLSTLITARLYRHEM
AQSKNSLSEAIIDGVAGFIVLDSQLRVIQVNQQFSRVSGYAFNQVESRPISDLCFMNNSS
LISTITRSLKENQRWKGELSGVSRLGEQFTVNVVVEKLTEILPHNNKYVVTFTDISRRKI
LERRLRMLVETDSLTGCWNRRRFDNDLKHYSNLAERYGYTHSCLALIDLDHFKAINDNHG
HDQGDSALKEVAELLRNNSRDTDIVARVGGEEFAILMPETNLAEAFEAMYRLKEVIAKGT
TLNLTVSSGVSEIQAQAEATYRSADKALYRAKGNGRNRVCSSSPGCATPIALG
>A0A7U7G969|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MNTDIPLRILFVEDVPADAELAARILSKEGLAFTSIRVETQEEFLNALIEYRPDLILSDY
SLPQFDGMRALRLALAHNVNLPFIIVTGSIDEETAVDCIKAGAWDYVLKERMARLPFAAK
SALERRKIRLSQAESAVMLRESERRYREIFNATNEAIFIDDAATGQMIDVNDAMLRMYGY
SSKQEVLAGSIGDLSANRPPYSQAEAEQHLRRTLEQGPQTFEWLARKRSGEEFWTEVSLR
GSDIGGKGRILAVVRDITERKAAETAIHHLAYFDALTGLPNRRLFRDRLNQALAAAQRSN
RWGAVLFVDLDQFKQINDARGHDVGDLLLKQVSERLNRCRRDEDTVARQGGDEFVVLLVH
LAATHSAAIRLATRVAEKIRDAASVPFQIGGLDYHIGVSIGITVFPKATENVDDLLREAD
TAMYRAKEAGRNTVSYFEPAMQEAVQARFALEHDLRQALARNEMRLLLQPQVDGQGRFVG
AEALVRWERPGQGLVSPMVFIPVAEESGIILALGRWVLEEACRLLKQLDAAGHILRLAVN
VSPRQFRQPDFVACVCEVLQTTGADPTHLVLEVTEGLVIENIHDTIAKMIELNRLGIRFS
IDDFGTGYSSLAYLKRLPLHELKIDRTFVQDAPTDPNDAALVETILAVARHLNLSVVAEG
VETKIQLDFLKQRGCEVFQGYFFDRPLLWPHFQEKAFLQMR
>A0A143QM48|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MRANDETPDPLLRTGVVVQTLLFGLLGIGTTFTQDGPTEGLGTVLTYAVCISTIPVARIM
SKAEFGMDWWSRRAPVNNWFVVYCELGVTVVTATYADPLAALQGAMLLALVGAYAAHFAR
PKVIWFHVGWSTVYVLVLGASALATTPTDTVSVVLRVVVAITVINGAVTLLSAFSRAVLH
SSRVHLSDAMTDPLTGVLNRRGLEARAVGAGNDPVRPALLLIDIDHFKAVNDHHGHSAGD
VALRLTAMRLTMSAGRHATVSRLGGDEFVVLVPDPTPTLGEFAERLRQAVHNVADDIPIT
VSVGAALPQVDSRSTRTVFDRTLAAADEALYRAKRNGRNCVALARPPGDIVH
>A0A174XDG9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MKQDLAALEEENKKLSKLANHDWLTSIYNRGATETKINQLLSEKKTGVLFVLDMDHFKQI
NDRYGHIAGDCVLQEVVRILNLMTFKQDILGRIGGDEFVIYMPLEQNQNFIDERCYQIRI
RLLGIQMTNPLINGISATVCGSLYQPGDDYKSLFDRADQLLLAEKRKKDRKPVVAAAEQR
RSAARKSIDIDMALIRSELSEQELISGAYCQDYETFKRIYRFVERRLRRSSESVYIILFT
LTDKNGDLPKLLTREKQIDTLKSVIQHSLRLGDVFTQYSSCQYLIMVSDVNSQNVELIAQ
RIYESFFSAMTEIEDKLLLHHCFPLKPAGTS
>A0A174IWM9|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MNKKVRSDSIAFKLALTFVVSVVIQSLLMTALLSLGGVIGQSRENAYQIFSEKVKNRAVT
IEGEMKNVWTNFELYTDELSRYFAEAERDENGELLEKEELLKAAAPTVLNALYYTKTTGA
FLILDRGDDENGSYPALYFRNANPNRVDERNSNTYLLAGPWDVAQETQVVTDAAWKYQLE
LTDANRAFYEKPFSSIGLAGDEKLLGYWCPPFRLYDGGEEVVTYSIPLVDQRGRAVGVFG
VEISLNYLYKYLPPSDLMAVDSYGYVVGIQTGENGEIRPLVTHGALQKRILQGASPMELK
AKDAENGIFQLENHNGNEVIYACLKEMGMYYNNTPFSGEEWYLIGLMDEDALLRYPHRIQ
EILVYSFLISLCAGAGIAVLISRWFTRYSRLLELSEVPVGVYEMGSKGNKVYMTNQVPRL
LGLSKEQERAFCRSQDEFQAFLKKICEKPTEDENVFCLERPEGKRWIRLTFREDDGKKSG
VVEDVTEETLKTQSLRAENDLDGLTRVLNRKAFERRQQKWDGLLRLGKPLAILMFDLNCL
KRVNDQFGHETGDKYIRFSARAISGALKDAWIYRIGGDEFAAVLEGVPENSIEECCRLSA
GQVEAYGKENGFEAGIAWGYAISASDSAETFGDLLSRADHNMYEMKKQMKNIDKS
>A0A202FFW3|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MTWHVWQVSPFITSIFFILGVFTLYQVLYDWIKSLFHFKNVKMTDDQLKDVFGILYMLIF
IFSMQATIVGKSVSWEFMNFQIIALIFCAYFLNIHIPYRYFIPIILVYMIFNSSIGYWES
WCHAWTLIMSYESFNYINRIQSESHRSFRYMMVGIVYGGLMWFFVMVKFNLTLTTFYEEW
FYLVIFEILLYSYVNMILRDSKLKLHLLEFANHDALTKAENYAAYTTEIQYEFESCQRNK
LHLSMMMFDIDHFKHVNDTYGHLAGDKVLQHVADVALTVINANDPKVKFYRTGGEEFNVV
FPGYDLESTKDIVDEIFMALNHLPIDINGKKIYISISMGVSTVSAKDIQPNDLYSRVDGN
LYHSKNNGRMQITAF
>A0A3G2IIS6|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. 3AFRM03|TrEMBL
MSTSRANRFRLPLANTLRVIHLCFIFVFVLTAILFWQQGQLFSQGYRTGQLSHLESVIAR
LESRAQYKVDNLRYLKRIFIEAMDDPIFPGSPVAPWEVNENAIQRPLWIGELPLPDTVTE
DEAFQGKESQEVRNQLNGLRKIQGLFPLATGEHELLADLYYISREGEFIASLSQEVNEQL
INSYNPHEKQGSFVLASPLLNPRRAPFWTRQNIANSDETVINAAIPVDFGGEWVGLLGIA
FDNQSVQKFLASSLPEGTQSAYRLYDEQLKPLTKAVGAENNVQLNVEQKKTILKMLIDKP
RGTFRSGSVFITFGKLRGTHSVLVSTQTLSQGLHEDFGRFSLLLVTMFLIFVLSLLGAHR
IICRLVGNMGNLQREMQHHALHDDLTGVLNRRGFFEKTSQVSPNYVDYTLVLLDLDHFKK
VNDMYGHQVGDNVLIHATGRIQRAIRKQDILGRIGGEEFCIYLPNSDLKTGIMVATRIKW
ELESSALILEDGSQLPVTASLGVASYREHPEYMLEQIQSLADMRMYRAKARGRNQVCWLG
EDKFQA
>A0A3G2IL56|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. 3AFRM03|TrEMBL
MIKQSTKELFAMPSFVLPVGLGLLSFIFTWYSLELSLVGTVLAPLWFPTSLMMVALFRNT
FRKWPMVIAVCTLGNLCASAIFQPLHEISLGYTIINIIEALLGASLMRRMLPQHNPLQNL
SNWVKLVICSAIVPPIVGGVLALWLAGPDSGNLAKTFFVWVLSETIGALALVPTALLFKP
GYLLRHKNPNLLLETIFTLVVTLALSYLTLRYMPWPFTFIIVFLMWSAIRLPRLEAFIVF
LGTLMVVSLMMATHNQVSMEPHTTVMNNAPWLPFLMILLPANVMTMVMYSFREERKHITE
SEARFRNAMVYSAIGMALVSTDGQWLQVNKSLSKFLGYTAEQLRSLTFQQITHPEDLHAD
LQQLNMLVSGSINSYSMEKRYYTSKGDVVWALLAVSIVRDVDGSPLYLIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLGSDVISWDKRMFDLYEVPPHVKPTYALWLERI
VADDAAAAEKTVRDALQARIPFKMEYRIHVKEGVRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVVCTDVDMNITFMNPIAEKLSGWPQQQAIGQH
ILAILHITFGDTGPVMENIHSGDYSRTTIEHEVVLHCRNGGSYDIHYSITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFENHLKRLLQSAGENRQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELSSLMLSMLRTGDFLARLGGDEFGLLLPDCSSDNARH
ISERIIQSINDYHFTWNGRLHRIGASAGITQVDADNRIASEVLSQADIACYASKNGGRGR
VTVFESSQHSIRKENQNLPMDEQKRIINDSPILMVARAIAPPRIPESTSFYLLSLRFWGS
DDAVLDESAFRAAVTDKELQCTLDLRIFEEFFSKYAQPVTNKGFGVALALSSHGLASDKV
VDEILARLARSVLPARLLHLVIHCEALQSEDEKIDSNLQRLRDSGCHLILSHVGRDLDIF
KRISRQKFSYIIVDEELIQNVHSNLMDEMMVTIIHGHAQRQFLQTIAGPADMPMVMDTLS
GIGIDLIYGEAVTQPLPLEMLLNTSYFAIN
>A0A5E4VBH9|diguanylate cyclase|EC 2.7.7.65|Pandoraea pneumonica|TrEMBL
MVSVSPQGRSAHADGAQQRRAASSSFGVDSSVAGKGKRFVRRIYRLRTIGLAIGFFCVAG
VFYRHDPPIASWLWVLLIVNGFVWPHVACALALSRPVPYRAERMNLLIDSAFGGFWVAAM
HFNVLPSVVVLAMMSMDNIGAGGVKLFLQGVLANVAGVLVGIALVGFVWAPASDTFNVLT
CLPMIILYPIALGKVTYDLAQKLAHRSREMEYLSQHDGLTGLLNRRAWEQRLADIHTHCM
ATGQPACLVLMDLDHFKRINDTLGHAAGDTALRRFSGLLRQRLRDIDAVGRYGGEEFGAV
LVNTGAVAGQDLMHHLLADLRARVAQAEAQLQTQMPVTDGQTLSLTECTVSIGLVPFSTG
FDSPQAWLQQADRALYRAKRDGRDGMVVFELNR
>A0A5F0JVP8|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. A11|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGATSFIYPSINVIEAVIGALLLRKLLPWYNPLQN
LNDWIRLAIGSALVPPLMGGVLVYFLVPTPEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTMAVTLVLSWAAISWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHTNAMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLHTDL
KQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHTDGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPLHIKPTWQLWHETML
PEDRAHAEKVLRDSLIARLPFKLEFRIRVKDGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LRVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
ASRLIHTINGYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGIV
TVYEPQQERDHSARSMMSLDEQWHMIKDNHLMMIARSVASPRIPESCNFWLISLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTSAAQVASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPLPGRLLHLIIPADVVCNPDENLQRGLQKLRQAGCRVIFSQVGRDMNVFT
HLSANMADYLMLDAEVVTNVYGNLMDEMMVTIIQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGLDFIYGDTIAEPQPLDLLLNTSYFAIN
>A0A649YNU4|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MLIKRRFGWIAVLLFAIWFLPVKAQTPNYKVAMEADDVVTRVLFDAVASKFQLDVQYVYY
PSFDAILDSVKAGESDFAANVTYTPDRALYFDFSSPTNIEYTYVYSATNATLDKLHTVGV
PKGTIYGELIRKAFPAIALVEYSGQSEALQLLKQGTVDGVVDAINQLKPMLLAGYDAQLL
NHQLSIKPVSIVSLKGAHHQLLKTIEHYVHSAEVQKLLRESINQYQFEIRQQALRQAVLN
SGINFNRPLRVKIENIGQYATYLNDGSIAGITADIVLQACDILMLNCKLESTADESWESM
YGDLIAKRIDVLSPIAISEARKDLVYYSDPYYQPEAILVKREGYKDNVYSNVSELIVERI
GVVKDDFYEELLRGLLPKKTLLTYDSSESQLKALMNHEVDYIAISRANFNTLLRESKDLL
PLTEDLLIGGYYTSDIAIGFAKNQVGASLAPLFSRALKMIDTERIVKRYDYRPDWKATLQ
AEQSFSRQSRALFMLVLGFLAIVAIYLHSQSTTDNLTRLKNRRSMHRRFRSGINAHYTLL
YLDINRFKFINDTYGHEIGDQVLKAVARQIELYWKGNSYRIGGDEFILIGQPEEVTLNAL
IDKLSSLHFVSEDHQVSLDVSVAIGISCPRDRFMTLQEVLNEADQAMYDHKREKHRCIIS
RQSNEQNVVHFSKGG
>A0A2N8ZC12|diguanylate cyclase|EC 2.7.7.65|Vibrio tapetis subsp. tapetis|TrEMBL
MTNKQTKKRALPTIQHMIKRSFLKTAILPLICIEITFLLIYWLTISLSNEQSVKVAKEFA
YHDLHFHTKEAASRVSHKLNSVSMLTNIYADQVSKVINDQVTSLPPESHNLYLSESGMYV
SNKDMGGSAVYYSGIHPIGQTEKDKVTRTSILDPLMKSIHQANSLISQIYFNTYDSYNRI
YPYIDAEFTYEAKMDLPSYNFYYEANLENNPTRTPVWTDAYLDPAGSGWMISSIAPVYST
QDVNHLEAVVGLDITLSKLINEVLNLDIGWGGYAMVLNTQGRIIAMSTKAEQDLEVKELL
EHDYKNAILEDNFKPDTFDLSQRPETQHLITQMQRSRDGVTDVILQDSKIVSWATLPETN
WYLLYWIPAEQIEHGYSNIKDNLTQIGWMMVAGLLFFYLLFYIYIRYQSNLVARGAIHQL
NTLSKLIESIGRGNYWQPKPKLHFLELDSLATLTIRMGRRLGEAYNAVAKAEYHAGHDKL
TTLPNRYLMEEHLHHSIDLAKRDEQLLAVLFFDLNKFKQINDTLGHTVGDVVLKTVATRI
TSKLRHSDIVARYGGDEFVAVLNNIQNIETVEALIENIENIESVINKPIEYNEGKCQISS
AIGYAIYPNDGNNGQQLIIHADTQMYKKKPTNSS
>A0A517SJL0|diguanylate cyclase|EC 2.7.7.65|Caulifigura coniformis|TrEMBL
MIVDFTKLNRLPSLPVVAIRLLEKFTDPNVALPEIVRIVQTDPAITAKLLRAVNSAQYGA
GRPVSDLNRAVNLLGKKAVTSLVLCFSLSEESMCRGAFASLYKSVWLQSIVQASAAEQIA
RRHFRGMEGEAFTIALLADIGRLAMLKTAPQEYAAVVDRSAREGLSLEQCEEEAFGIDHR
RLSLALLNHWNLPKRFSNAICRRTSAPDQLASLPADEERAMTFTTALATTIADYFCISPR
GLSFALMADLGAELFGMTPDNIDALLKETDRAVKSTSELFETDPSQLGSPTDLMAEAMEQ
LCAIASSVHDGQTEASVRSRLLDENGQLKQRIQDLVQRSCLDALTGVFNRGSFDEQFTLA
TADAMIKHDELGLLFLDADHFKKINDEYGHPAGDAVLKRLATVLTSAVREGDIVARYGGE
EFVVLLNKPSLAGLESLAERIRAAVEAERIPVDGGGVIRVTISIGGALFVAPHSDDTPGN
LLVAADSALYEAKDSGRNRVLIRHVHQCGSEMTASDR
>A0A8E6XSY4|diguanylate cyclase|EC 2.7.7.65|Salmonella newport|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLSVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>I6CX84|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MFRPDLWGKPVVVLSNNDGCVIARNAEVKALGVKMGDPWFKQKDLFRRCGVVCFSSNYEF
YADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVG
VGIAQTKTLAKLANHAAKKWQRQTGGWWIYQIWNASVN
>A0A3R9QNI0|diguanylate cyclase|EC 2.7.7.65|Enterobacter huaxiensis|TrEMBL
MNKDFTSTSRPTFKRTLRRISMLSVTITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDPLAANETLATLGKQGQFAEAEVLNVHKKRFAHWSWNPDENTDTLGALVS
RWLFPLPVSQPIIHNGNMIGEIRLTARDSLISHFIWMSFAVLTGCILLASAVAITLTRSL
HHGMVTAMQNITDVVHDVRTNRNFSRRVKAGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLMRTAMHDPLTGLANRAAFRNSIAALMNDTSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMVEFGDKRHQSYRLGGDEFAMVLYGVHSESDVQHICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASLEALLEQADRNMYQVKNQRTKTIS
>A0A5C6DWR8|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MGYIAKFRTPPTPDVYEVWYRYAEGADPALREQLSYAVNDAENASYQQLQQLHQQFYSGG
DLTEINQQTGDELAKAMGGFQRMIKEQLSAGSEFESSVSSANDRLVGDNPTVEDLEVSIA
AVLSSNQRMQSQLQNMTLRLEETRSQVTKLRENFIESQQKLMTDPLTGVGNRLFFDTMVT
NAIDHPERSERYFFLLLVDLDEFKTINDTFGHSTGDNVLRFAASNMERIAEDASIARYGG
DEFAVFLNTEQVEEGVDIADAICQFFAKNKLTLNNTGESIGQLTTSIGGALLRAGDDRDS
WFERADKLLYNAKKAGRNRTMVERKIS
>A0A5C0WED9|diguanylate cyclase|EC 2.7.7.65|Bacillus safensis|TrEMBL
MLRDLFINLTILVTFHYLFILVFKENFLKKEDTLLRQICKGMLSGLLGVLLMFFSIKTGP
AIIDLRHIPLILTAFYGGIAQTMIAAFVVIIGRLLIEANIASSINIFSMMFIAAASFLIA
ERHMNHVVKMLLSITIGNVVATSLFILIVHETSFQLHSTYWIFSYIAGLFNFYVIEHQTK
AYQLLNLYKFQAHYDFLTGVLNKRKFDEVLSDAFTKKLKQPYHQMSLIYLDIDYFKTIND
QYGHHEGDIVLKEIGTRLIKNTRSSDYIGRIGGEEFAVFLPNCTIEKTWQIAERLRKKIA
DQPIYLKNGLSIHTTVSIGCAYSHGTGADIKQLPIIADQELYKAKESGRNQVSFSERKKD
HLT
>A0A7U9S3F3|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MNKNIAYVSITEWNRKVMRWIWISIGLVIFIEILLFLFYQPVPECSKREYLDIFVIRPSI
MIVMYAGCMELIFRFFGEALGEYVTTILFLLIQFLLLGTVAAVHSSVPYMCMILTYPVIF
ANVYREKIFRYAAFAACILVYAGINYGFIPSTEFRPDNSREVYLVIFVGFTIVAFSFSKV
LTSVVVNFEKENRKIYEENQKIHEEKEKILEISQRDSMTGLYNHKMFYDKLNEHLQLCSE
ECPVSLVIIDIDNFKRINDTFGHAMGDNVILKIVSIIEKNVTDKDVAARYGGEEFGLILA
GKTEMEAYNVSERIRREVENAEVDGVTGRITISLGMLEVKPGDKNGILLFKEVDSALYEA
KQTGKNKTVCRGWRKGDNNEYSYQNFSSSQ
>A0A7U9RZV3|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKGLWEYISAKAKYALSPRQVMSLIMFVLGIFNMGLLIFFVIFSIYPMVLVSMFSVTLYI
YCFIQASRDKNLLLVFNLSYAEIMIHAVASVLLLGVDSGFSLYIIAMLPLGYYASYNFSS
EKKSVNPMLYVLFSGVAFCFARILGSSMHPLYSYGNKSIDRAMYMVNYFVAVIAIVLFFS
TLLNQIKYLESQQKNQNKKLEELSKTDALTGLANRRSIQERYEDSELLQESYAVILADID
DFKKVNDTYGHDAGDRTLKAVSAVFKNAVRGEDIVCRWGGEEILVFLPKCPLENAKDRAE
AILQNIRKLQLTTQEHSSFGVTMTFGVAISEEAGSFTEVVQKADERLYTGKQTGKNQVV
>A0A5E0ZWT7|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MKTPATPANEMERLNSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPDTVPRNISFCGHTILSEAPLVVADMRQDDRFADNPLVAGEPGVRFYAGFPLRL
RDGASVGSLCLIDYSPREFSAADLAVLGDLSALAEDEFAAVSAATTDELTGLFNRRGFNQ
LLRFTLSVARRRAEPLTLGWLDLDRFKEINDRYGHEEGDNALKVMAELMRTSFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVEQYNARRLHPWSLHFSWGLSEFDHNGNDLQ
QWMKDADEKMYAMKQQRKRAT
>A0A2C9D3M6|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MTLEKTHGAGWLYGWTAGLAVLSVISSMCITLAIEVIFLLPIYPTMDLWTGVLIGGAVPA
LLATPMIFALLRLLQKLRHLNVRMRQIAMTDDLTGLLNRRAFMDRAGDKNGRIAEGVGLL
LIDVDRFKLINDTFGHASGDMVLVRTAETIREWAGEGSLVARLGGEEFVVLCSSVEAGDT
LAIAERIRQEVESGRMLFADHIDVETINIGVACARQGETVNSLLIRADNALYAAKAAGRN
RVVPCKEAPPVLNPAEASMPRPPAGQSEPSGCESQLAG
>A0A2C9DC13|diguanylate cyclase|EC 2.7.7.65|Hartmannibacter diazotrophicus|TrEMBL
MGDVTSKSNPGRLKRDIYVAASLTVIAFVITLFFIVDRASVVANGLALQDDFELLNTELA
NQRRSAEVTMNEATTSLDGLATMRRRDPDMDFMIQEMKTWITEDYGIRQVLVVDGAGVFR
FAMQDGNETAEPSSLPLSQFAVGSAERARAWFEEVKPQLPKGWELKNARQNDRARYVLSD
FATVDGQFGMILAQVVVPFADDGIFMEGDGQVNVAFRPLDYGGLDAAAQRLSLRGFRVAS
VGDSPDIAARLEVASHDGTPAFALLWDKPDPRTPILLAVLPLGVALVCAIVALLAIMLRR
YRLALHELAASEELNRRLANHDALTGLANRAQFDRRLDSLIKSNPRDGFAVMCIDLDKFK
AVNDTYGHNAGDAVLVAAASRFAERIGEKGLVARTGGDEFVALVTSGVDPRDLKMLGECL
IADACLPVPFESNDLQIGASIGVSIFPGNGRTAKDIINSADQVLYDSKRAGRGRCTLAEQ
SVRDADRTSIHARPSATIAMPA
>A0A330DUH2|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MQRDTFVVKQYFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALQTPLGFDVLRDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKVIA
ENCRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>K1KPP1|diguanylate cyclase|EC 2.7.7.65|Solibacillus isronensis B3W22|TrEMBL
MFLELTINFSILFCFTILIFWPFIQYEDNPFIHKYKSIIVGVTFGCAAFILTALATPYAH
GMLINNRIIFVLFSGLLGGPVSIFITGFMIVISRYVLLYTSVLSFIIMLNTLVVTVIACF
FAFKRPITYQNLPVYFFVITIEHIIVLIIYDRFQINNLFYLILYFAVSTITFFAVRKILM
QLEHKNKQIRQIYAMRKTDLLTQLPNNIAIEQKLLSFVNAKIPFELLHIDIRQFRELNYM
YHYKAGDEVLVQVSKLLKDQLPKNALIGRIDSDEFYVVLPHLVPAEAVTLANAINKAVQQ
LTFENYPSSQLILAIGICSFPQNGQSVKELYRFSYEALLRAKHQANIQICHYNQMKQRY
>A0A6J4G235|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MVVLTAAILATFALLAWRDIENRYAAARQGLDTTWFIGRNVAERFHHIDRELDALAQALG
ESGAESLGRHETWERMAHIVRSTPHVRSMGLSDALGRIVQSSEKEGGYPGISVADREYQR
RLLADPGQGVVIIPPFKSRIHGELVVGLARAIRGRGGRVLGTAVITVAPSAFDLFASLPN
LPRDSAIAIHRRDGINLFRAPVLAEQLGQDLSGTTLFAKALPESPSGYLFTPPKGSVVDG
TARLLAYRALDEWPLVVVVGIRKDEITAGWLHDWGRNGVLVGMALIGFSWLALAVQRQAT
GRLEAELRFSRQELVTRAKVESELRHWASTDPLTGIANRRFFIESLDREFERAQRYGRPL
GVLVLDVDLFKSVNDRFGHAAGDEALKIITRVSVDCLRESDLLGRLGGEEFGVLLPETGL
AGTSETAERLRAAVAAATFIVDGEARPLSVSIGCAVLDGDADLDRLLARADKALYRAKAG
GRNQVTVEPPDPHPPH
>A0A098G335|diguanylate cyclase|EC 2.7.7.65|Legionella fallonii LLAP-10|TrEMBL
MRRQEIDYEKVASAAELIKKRGKDPSLTDIGEVLGIVGTHPELSVLLEQWYHNQPEFKRT
QNRPLTDNISIKTDEIVKKNTELEKSLSILRATLESTADGIMMVNGQGAVVDWNQKFVEM
WRIPSYMMESGKESISFDYILEQLTDPQSLISDVQYLYQNPEWQGELPELTFKDGRIYER
FTQPQRVGNQIVGRVYSFRDVTQKRMALDELRIRERAIEASTHGIAIIDISKNENKVIYV
NKAFERTTGYPEMQALGKSLHTLQGIDVDEVNNKRIQLAIRELREETVEMENIRRNGEVF
WCEISVAPVKDLLGHVKHYVCILNDITQRRDMENQLIMQATYDSLTNLPNRVLLMDRVEQ
AILQAKKKNTILAFLFLDLDRFKMTNDTLGHNMGDKLLQFIANRLLIATDDFDTVARLGG
DEFVILLSNLDEMKQAETMAQDLLHAIARPIQIDQHSLKITASLGISFYPRDGQDYESLM
KSADLSMYHAKDNGRNTYRVFEPEMNRRVINHMQLDTALRDALKNHELYLVYQPLIDLKR
SKVVGFEALLRWNSKNLGMVSPVNFIPMAEENGLILDIGEWVLREACTQLKSWQKQGLKN
LSVAVNISGRQFRQTNLPDLVAEILKSTGLQSKHLELELTESLLIEDIEHVVETMYALKD
MGIKLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFISEMATNQNDAAIAKAIINLGHSLNI
EVLAEGIENEFQRDFITAHGCDFAQGYYYKAPETADKIYEFIRGLHDAKIKN
>A0A1J1LMU6|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MPSNLLIVTSDTPSIDAINLMNQRDHDCILVIDEQRLIGIVTERDIVRAIAAEIHFDQVP
ITQVMTANVITLLESEAADSLKVIQQFNHHKIRHLPIVNLQGEVIRIITPKQIRDRLIPY
DLLKLRRVEDVMQIRVIHAPPSTSIKHLANLMITYQVSCIVITQLQNQGLIQPIGMITER
DMVRFQQLNLNFELTLAETVMTSPVIAIAAQDSLWLAHQQMQRHQIRRLVVTTAEENLIG
IVTQTHILQVIDPSELLETIDILQHTLEVQTVQLKQEMQLVQTLVQQEARYHHLLDSFPE
FVCCYTVKGSLTFINQAGCQYLGQSASELLGQSIFSLFPDHEQNLGLEQITHLLETQETL
SYQSCLTEESNQQRWLEWTVQVIPDEMGQNWEFQAIGRDITKHKQVELQRQQVEAALSQS
EAELRAVFGAMSDLVLILDEEGRYLNVITNNPHILYLPVDQILDKTPQEIFPEPLATQML
ETVQKAIATQTTATLEYCLEIGGKNSWFSANISPLSSSSVVAVIREISDQKRVEETLQET
NLALAEAQKLAHLGSWSYDLLTQEIQWSEESFCIYGLSSDHPVPTYEELLQVFTHPDDRE
LIRHRMEKALNEGQQFQQEIRIFCPDDSLRYLLIKGKVMRNEQGQVIRLFGTLLDITERK
QIEETLRQLLKRERVVTEITQRIRQSLNLEEILTTTVTEIRKLLQTDRVLIYRFEPNGNA
LVIVQSVGVEWMSLWGQQIPSSYLTQDQCIIPFSQGCLHNISDIYTAHLKSDQLQWFEQC
QVRACLGVPIIKGELLWGFLMAHHCTCPRQWAYWELDLLEQISAQVSIAIHQSQLYEQTQ
EQAQREKGLRRVIQAISQPLDLETIFSTATLEMGQLLNVDRVSIAQYIPDQNHWIIVASA
TQGSQIHDTIGIIIPDDDNLISAQIKQQKVIRISNFQQYADQPINQNLTEMNPGALLIVP
LWVGSSIWGSLSVYRHHQTWIWQDTEVELACTLVEQLQVAIQQSQLYQQLHIANQRLEGL
VMMDGLTQVANRRRFDEYLEQEWKRGTREQQPLSLIFCDVDYFKCYNDQYGHLAGDECLI
QVAQAIDQSVRRPGDLVARYGGEEFAVILPQTYIEGAIQVAEIIANTLNSLQIPHPESPL
SSHLTLSMGIASFMPSVHSSPQVLIEAADQALYQAKAQGRNRYIVYTSPESASESSH
>A0A727YSL5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:g,z51:-|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2G2BSI4|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVLSREIEIARHSEKCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVDTDQDGSRLFAERLRHAVAKEPMLAAADTLLNVTVSVGVT
LHDGHPDYQRSMQRADQALYQAKRSGRNRVVVAAATE
>A0A356QK89|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEW
>A0A128EZB2|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MNRISIRWLYHLVIWTILVTMMVCVDAITIKEDAGIYEEIIGLGIGLSVAFECFRYESMR
MATWLWIGWLVYGLGNLFDVLDELVSSEKFKILYLDTSLTIMGMVLISYGFLKQTVAGEK
MIARLSGEVAANKSLRAKLYKDARLDELTQLGNRRACFERFSKLGLITHHLYYFDLDKFK
QCNDTHGHRVGDKVLEIFGRNLSSTFGSQAAFRVGGDEFVALSKKEHDLGELAASLCAGI
ADYGVDVSIGSVEVKDDANIDELLNRADGEMYKAKFRRQSRAC
>A0A128FED3|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MSKEIFALSSGYLKKVVPLLMKYQVPATPPNYALWYTYVANADNELSKKIDESIKETGTL
SPTLSEELYNTHVADEKVKDVDEFQRGLQALALEMGNTMEDTLKDTATFQNTLDKTFSQL
ARVGEEALSMEETVAVVRKAVKGSNELRQSTNFFKSQLADAQKEISRLKETLQQANDDAL
HDALTGIYNRRAFDTELETLAAKPPPKGFSLLLCDLDHFKSFNDTYGHLMGDQVLKLTAK
RLSDYCRDGINAYRYGGEEFALLVPNRALSGGCRVAETIRATIDKLAIKDKKTGKKLDNI
SVSIGVAEYEKGESIRNLISRADAQLYEAKNLGRNRVMPVT
>A0A6N3R311|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKYPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A6N3R4Y7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MVSMGTQKLKAQSFFIFSLLLTLILFCITTLYNENTNVKLIPQMNYLMVVVALFFLNAVI
FLFMLMKYFTNKQILPTLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYI
FRQLSFICLTSLALFCYGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLY
VVDYCPDNHTATRGINYTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLL
LTLDEYNYTIWYISRGIEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFN
SVESLLSRPVVKDFCVMLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARL
EGEVFGLLFTELNSAQAKIIADRIRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNI
SLVMTEADKALREAKSEGGNKVIIHHI
>A0A6N3R224|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A5P9QBF4|diguanylate cyclase|EC 2.7.7.65|Luteimicrobium xylanilyticum|TrEMBL
MTSQNKASGQGRASGAHDLGGGERRELKYRRLVGEMRRRILDTTWPPGARLPTLREIAAE
SGCSLTTVRHAFDELEEAGLIVRRQGSGTYVDEAPDRQLGRTVVGVLVPDTAAYFPPILQ
GIEEVLAENGARLVYASSQYDPAVEKEALAGLLAAGIDGLLYTPLIEPSDGDVAKHLARV
AEIPVPVVLVERRLSGAGPADDTYHVCTDHEGGAYDAVRHLYAAGHRRIALAVRRSLGPA
AAPIEVGFGRAVSDLHVTGMVDGAPREAWTPERADLAVQRIVREGCTGVLCFGDREAILL
IAAARRAGLRIPEDLAVVSYDNEYADVAEIPLTAVSPRKYQLGRMSAEMLLQRLRSDDVD
GPQQVRLRPTLVVRRSSTPAHREDATAPADDNQRTRP
>A0A5W2Z6Q5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLLSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
MLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8I1XNN3|diguanylate cyclase|EC 2.7.7.65|Xanthomonas manihotis|TrEMBL
MSMFVVRWRHGLAAFALLLGSGMASAQPQPWKTIEAATIDDPVTALQIAQGALQRASRDH
DVDAEFWALLAQARVLISLEDSERRQAVLTQARGKLDQLHGSTPQARLWLDIVQALSDVR
ENPNRVMVARLEALRQRASALGRNDLLCEVEAVDMWSMLASGSSDESWSAARGSYQCAAR
ENLLGLELDALTQLGALASRVGGRAAEDNETEDYLQRALARLHDQPARFQRSLVEFEFGT
ALATRQPEAALLHFRRALALSRELRDQAGVAAALTSASEALIETGDAASALTMAREALPL
MQQQGNIGRVAACHAVLLQALIALKAQGLDAEIVAAKAADDPNLTLNRRAQLVDAIAQAL
AFQGRHAEAYQELQRANALRAQSLDRQRDTVMLRLQARYEDARRGAETAELRRRSETAQL
ALQAREAGQRTLWIALCAACLLLLGALVVLAFGARHRRQLSRLAMRDELTGLPNRRAIRT
EAQQQIEQALRSHTSAMLALINLDHFKQINDVYGHATGDAVLKALANASRLALRGQDRLG
RLGGEEFLLVLPGCGEEEIPTVFTRLRSAVAAINIAGLPPDQPVRFCMGAVRIVADTGLD
ALLSQADLALYAAKTAGRDQWAVC
>A0A8F0CFP7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELVDRNMYQAKHRRTERSLN
>A0A7T8LKR7|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MNKERSLSRPTFKRTLRRISIISVLLTMTLIWLVICIASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAVADTLATLGRQGQFAAAEVRNKNGHIIASWRYNAQAADDKFIGLISQ
WLFPLPVSQPIWHNGRAIGEVQLVARDSLIGHFIWLSLAVLTGCILLASAIALLLTRYLH
NGVVDALQNITEVVHDARINRNFSRRVPDEPIEEFHLFAQDFNSLLDEMEEWQLHLQAKN
AQLLRTALHDPLTGLANRAAFRNCINALMKDSSARSSSALLFLDGDNFKYINDTWGHPAG
DRVLMDIAKRLVEFGGNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQEFNRPFELH
NGKQVKMTLSIGFALAWEHTSTEKLQELADRNMYQAKHRRTKRLLK
>A0A828U966|diguanylate cyclase|EC 2.7.7.65|Escherichia coli DEC2D|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENEILDNEITAALEVGYLLRLAHNSSSMVELAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDGKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRIDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQMH
QLHFLSFRSILTILKRLMTALVIRWATVFFLMLPD
>A0A5E4UFP9|diguanylate cyclase|EC 2.7.7.65|Pandoraea soli|TrEMBL
MVKSLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSAMQAQLDTQVQLVAEQLDDKMR
GKFLALHRMARHLGNPDAMTLAQFDAFAHMSVSMPETFNTIFVAAPDGRMRYDSTFPATA
INIADRDYFRQLLAGAPQAVSGLIAGRITRSPGIILAVPVVDTQGKTIAVIGGAINLLRQ
NFMVDLASNAVGTSGRYCVTTNENPARYIIQADVTKILSPVGPAQTLCGVHDPAPNPLLH
MHPLVARATMTTTGWSVVAVLPGAEAFDPLARVRRRVMLLAIAAIGLAAFAMWWMVRHML
LPLDTLRDLVQRSASDMRAVQSLPVQRADEIGALANAFRDMMEQLSDRTEALEGSREAAR
ASVRRMQEIADRVPYLVVFLDSNERFAFVNRACELRLRRPRERILGATASELLGPSLYRE
FAPHLARAFAGEAATFIWDFGDGAAFRCFEVTYQPEWALHDVLVGVHVFVRDITVERTNE
RRWRRESHTDHLTGLLNRKGFDQALTGALRVAREGGGAQALLFVDLDRFKLVNDTWGHAL
GDELLRRLAKRLVASVREGDVIARFGGDEFAVIMRDVQDILDVERTAMSILDATSRPMSL
SVGAVTVGACVGVAMVASGEVKTPDMMFDAADRALYDAKHGGRGRFVLGDGACVAD
>N6YW59|diguanylate cyclase|EC 2.7.7.65|Thauera linaloolentis (strain DSM 12138 / CCUG 41526 / CIP 105981 / IAM 15112 / NBRC 102519 / 47Lol)|TrEMBL
MKRKINSAEASETVQADWISLFDQTPPAARAAVRDLIEKQRHVLADAFYERMMQDTEARS
FLDNGIVHDRLHASMQRWLSTLFSCETQEQFVTAMAMQRHVGEVHSRVDVPVNIVARGAR
TLKNQIGLHLAHGTLDRNGLVEAVMYVDSLIDLAFEVMSSAFVASHERTARIDEAYRSFS
SGQNMSLERERQRSALLDWENRYLQAVMTALPGDDLPRINGSSFGLWMQHKAPAVFRGPS
ELHAVRALMRSIDDTLLPLCAQQLGNNPGEVRHLLKQVQSKVSELKFLTESMFERLIDLE
SGKDALTQLLNRRFLPAILARESEIARTEGKPFALLLIDVDHFKHINDEYGHQAGDRVLQ
QVAMILQNSVRAGDFVFRYGGEEFLVVLVEMSHAHAMRVAEKIRTRIADERLLISNGGQL
DITVSIGVAMHDGHPDYQRLVNRADNAMYRAKQGGRNRCEHDLGFCTVPA
>A0A0C7G5W9|diguanylate cyclase|EC 2.7.7.65|Paeniclostridium sordellii|TrEMBL
MKFIKKYKLILNIFLGIIITLIFMISININNNKKNIKEATKKIKYNINEGNYVNARRICN
LTFSKIPKYEYNILFKDIAKMSKEIKDIPYGERCNEKMFLEMEKYKFLSKEHRFKIYENL
GNLYLIDSNYAKASEYILDTLIMSKDMEYNIIEAKQLINLGVLFSQIQGYDTGVETIKES
LKINIKNPKQAEIIRLYAYVNISEIYLRMGKYKECERYLSMINKDRKHVDIKDYSDIDVL
ANTIQANLYLNEGKYELAKEYIELAEKFLKFNDEKIFKYTKELLYLTKGQYYSSIGNYYK
SIDIYNKILSFSDYKNNNSLNEECVLEKLVKLYDKTKQYELEDIYIDKLISAIKNNENIR
YRDYSNYVLEQAKEKYIVRKDRESIRFLMLIILCGTIIIGYMYKINKKRLKKMKYITLHD
NLTGVYNRGYFDEKYKELINNKFKFSILMIDIDNFKYLNDTFGHQFGDEVLKTITSVILN
LLNERCVLCRYGGEEFVILHKYSFKEESVLTAELIRSAVEHLSWSKDIKVTISIGIAYRL
NDGLDTLSKADMNLYKAKNNGKNKIVV
>A0A2S1FFE1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter schindleri|TrEMBL
MDNECMDMLAGQWQHICQNYSSDDLVHAFQFIQDNALILVEEFYKNMRLEKESAEFFSDD
LIQQRLRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERK
IFELLEEDDQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAV
QKDKQRSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIE
RIHQVDTLNQIILECQDEAKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQQYS
QGSDYAFRVGGEEFLLLLVDTDQRRAMHIAENIRKFVEEGIITTAQGIQFKFTVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A8F9PEJ9|diguanylate cyclase|EC 2.7.7.65|Paeniclostridium sordellii|TrEMBL
MIDKHVKQVLDNMPFPVWIKGLDNKIKYANSKFDDICNLSLIGKENEYDRLCEECYLNDK
CNNLMYEVIENNEEMIQFDVDIYDKISKCYITQFKDKNKNVIGFMGMLMDIRCKCETRKK
LDKNEHILRTIIDTIPDYIFYKDKNCRYLGYNKKWKDFYMNLGIHSMIGKSDFESGAVPY
ELAKKFVEEDKYILKNKKIKICEREFKDKSGNLRVEETIKVPVINDNGDVWGIVGLASDV
TEKIELKEKLIKLSYTDSLTGVYNRACFEDKKNELNKSKYLPIGVIMGDVNGLKVVNDTF
GHLEGDKLLKEIANVLKLSTREEDYIFRWGGDEFVILMPNCGKYKCEEIIANILNRCKKS
KFNLIELSIALGSSIKDTLEKDLYENLKEAEEKLYRQKFLKEKSIQSSIIFSLFQSLHDK
QIESKIHIQKLVKYALKIGYKLGFTPIQLDELELVTKLHDIGKVGIDKDILLKKEQLTDE
EIKIIKTHTEKGYRILQASSDLSHISRVVLTHHEKYDGSGYPLGLKGEEIPIMARIIRVV
DFYDSIMDSKYKNRLELKSNAIEEIKRYKGKKFDPKIADIFIEILELEKEY
>A0A0S4LIK5|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrosa|TrEMBL
MSILLIDDSPDDRLLLQAILSAAGYEHIIATDCAAAAFKQLGLDGGKQGLARVDLILMDM
LMPQMNGIEACRQIKAVDRFRDTPVIMVTVKTDPVDLQLAFAAGAMDYVAKPINKIELLT
RVRSVLRLVHEIDRRRAREHELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRALRESTPLSLIMFDIDRFKAYNDSKGHTAGDECLKQVCAAISSAVNRPGDLVARYG
GDEFVTVLPGTGIDGAAQVAESLRRRVEALGIQQTDGEPVTISVGYACVVPSRHSSPTDL
VKAADQALYQAKQEGRNRARSASILSLVQDSPST
>A0A2X2SWU0|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MTINIKDIDSSLSELNIAIRDHYNWANKCLRLSLLGGEPDKEINDLHAHQHCRFSRWLTQ
RMQGVSLDRELILLIDKHHIAMHAAARALMLSIIARQVSAELLNHYNEAQQQFISSIDQY
KEYLFSYRNLYDALTGLPLRHLMYQEFPLIRSRCERAERSLYLLILDIDRFKTINDTWGH
NAGDDVLRSVASIFERGHAQRGAHLSLRRRGVYYAAGRRAAGEQAEGAGKRICQHLASHP
VSVDDQAIPRDGDRGADLCLCG
>A0A7W6XI38|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. CIR48|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDID
GFEVCRRLKTDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRPSSYERLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKIELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQASTRGKPLALMILDIDFFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>A0A724ITA4|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis PT4 (strain P125109)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPRAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3EYQ3|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MTKVKNLRSLNEDVDSMTDVEKEKLIFVMMDLDHFKRINDHYGHITGNRALIFFSKKITT
FLSEAHQDQVEVYRYGGEEFLVIFKDSTLKSVQKTILRFQAFLLKNKLNIGGERKITLYF
SAGISKYDSSLDVYELINQADQALYAAKKRR
>A0A517R9A1|diguanylate cyclase|EC 2.7.7.65|Gimesia alba|TrEMBL
MNSPLIANSNSMPQQQSVHGSYNMGSSQILKELIALSTEHEEFSLESGETDFVDQVISRK
HLRKLLTALQARDASTLCHSRRVAFLAKGIATNLGWEGIHLKRLEIAALLHDIGKIGVPD
HIMLKPGKLTSDEIELMSHYHNIGIDVLQACQTDHEVLTILSQTRYHFSGATNGFQYIGS
DVHQGARILAIADAYDSLATDQVYRAGKKHDEIMAILMEAAGTQFDGNIVCALSRWEQNE
QDVFHDALLEVNRLYQPKPFSEQEAQEANLINNIFSYLFQIESLYDGFYIVNADFQFLLF
SPGLEKLADIRAIDILGEAWTANSLPLTNKEGTSLTRAECSMNRVIANGKPMTTEFMLER
PGGRLINIEVQSVPMFGEDGHLMGIAEIYRDLSRGLKRPQEFNDLKQAASMDALTSVANR
GELETQLAIMLSRFNKETDPTPLSLMFIDADHFKNINDSYGHSVGDDVLVEMARLFQHET
YSGELVGRYGGEEFVILCPETDLEHAVKKAERLRLAVSNLKLEKLEKTGLSASFGVAQVE
EGDSVESLFRRADSALYHAKETGRNKVCSLTSHQLLSGIDPISDSVETTVDEMVFENTFQ
ALISSDIIVYKLGGFVNDNGAKLTEVNTNRAVMQLGKSGLLPFWGKTDDRKPVEVEVEFG
CAAKKANSNSRSSTPRVDVMIRITPQGWVKKPQLFQQRANRVYRLLKDYFAAE
>A0A2I8NYJ3|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. LSNIH1|TrEMBL
MEHDIVSGKDAFTARHRFHPGRVVNICFIVVLIFSTLLTWREAVVLEDAYAASQKNHLET
VANSLDRQLEFSVEKLLFFRNGMRDALETPLASPLLRNTVDHFNDLQGKPSWQLTFDVRR
TLPLNGVSDAFVRQTTSLSRDDERIERELSAAFEMGYLLRIDSPAAHARRVVYVSRAGFY
VSTDPTDWGGDIISRYYHSVTRPWYTGQSERENRARSVRWFTHGADDRTVTVSVPVDYQR
YWYGALALEFTLPGLKKLLQDAVDGNGEGEFQLYDKGFNLLATSENIADNVNHFDERERA
QIAAALEKDTEGDIRLGSRYVNWHHLDHFNGLVLRIHTLREGANGDFGSITIALAMLWLL
FTAMLVGSWFVIRRMVSNMYRLQHSLQWQAWHDPLTRINNRGALFERAKALAKRCEQQNQ
PYSVMQMDLDHFKRVNDSFGHQAGDKVLTHAAGLITRTIRDTDVAGRVGGEEFCVVLPDT
GPEQAMAIAERIRERINRREILVKKSQTTRVSVSIGVSSAEESGNYDFEQLQSIADARLY
QAKQRGRNQVVGQDEKK
>A0A447SWF1|diguanylate cyclase|EC 2.7.7.65|Legionella sainthelensi|TrEMBL
MPFSYEEEMIFLFEGALRSIPYNTILALLLTLDLLHNKAPPQLMIWILFIILNSIIRWIF
CHYVIKKHVYMTPKMLAIFVLLTFFMGAIWGSCYLLMLHHISILQEFIIILVLGGMSAGA
IASLSVYLPAYYAYILPMFLPVITYNYLTFELDRAMLATMFLLFVLMLVTSARINNLLLN
RVFRLSREKQVLIDDLHQLSITDPLTGLYNRRYFESILKTEWGVAQRNHYPFVLISIDVD
NFKLINDNLGHPYGDHFLIFISELLKSSFRRSNDFICRIGGDEFSVILVNQSLQESLAIC
DLFNNKFHQNKPQEEAIMEQITLSMGIAWIKSNYNLQIEKLITCADEALYQAKNKGKNQV
EVIGLD
>A0A3S4GH66|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MTAAAYLLAINLFVAGIFAIAFGSVAAFQRSSRGAMWLAFSYCLGMVTAVMEFILPYQTD
HRPVSLIIAMSFVLALAGCCIGLARHYRQQPPWRLLLVLTGASLIGYLLILDMPRTDLVR
GLAYQAPYSVMLLVGAAIILRHRGNGALDYALLTLFIAAGLHFLAKPFIAAVLGSGASPQ
LYLASSYAAISQTTGAVMLISNGIVLLLIIVRDVMADITARSETDTLSGLLNRRGFEDRA
DKALSLSLRSGVPAVMVVADLDHFKQINDSFGHAAGDAVITAFGRVLKQVASEHSVIGRM
GGEEFAVFIPGANLVAGRLYAETVRSVFSRVALEEHGIDRPVSASFGVSQFRASDRLPDL
LRRTDAALYEAKSNGRDRVCIAETETRPSLVAIAIAPREDKVPV
>A0A701ULV3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 47:b:1,5|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLENELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S4GGY3|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MFDTAAGDPFGIDRFPVGCIATDDMRVIRFANAHAAMQLDRAQDDLLGLGIETLLTPASR
IFCDSYVLPILLTKGHCDEVLLTVETGSGTRAPVVVSAWVHGDRPGFVFWSFMRADKRDK
LQTEVLASRNLLQKQARSLKELAARDDLTGLMNRREFTRMIAPFSAAANRAAASVVILLL
DIDRFKAVNDTYGHLAGDDVLRQLGGAFAPLVGSNELAARYGGEEFIFAVTATNAEAASH
FVCRLHKAAASVTGSGAPITVSIGLYCWPPQSGESFKSAVKAADRALYEAKALGRNRTMM
MDADGTLVPFG
>A0A510WZ26|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQARKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A1R7QEN2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MIKKSVFHSLDLQKLILILIIGCVSSLFLISIFVLNYVIKEQLTENSLAANQRYASKIAF
STDKYFESMLSELRYSAQIVGQDFSNQQILKAEVTRLKDQSKKFNSVTIIDKNAFILEYS
PQTIHVDPKKQYRTPGITEALKLKKTYISSPYKGLSNNLIVLIAQPIFNRKNEFLGIVTG
SIYLNKENLVSELLAATYSYKRSYTYVIDNKNKIIFHPDKTRIGDSLKNNTGMQYITSHS
TGKIALLNSKGIENLAGFAAIPSVNWIVVSQQPTLELLSQANSIIVKVTLAMLGFYLLLF
IFVWKLSYWISSPLNKLAQMASMLTRPNIDQDIKNIDPWYFEALRFRTALLLSSKHFKDE
IAELQQHVNTDPLTGLYNRRGMKLFLNELEATNTPFSVLTLDIDHFKAVNDNYGHDQGDH
VLKKLASHMKSNFRQHDVCCRVGGEEFIVFVVHEDPKIAYIAAERLRKTVAQSYIDPIGT
ITVSIGIASWPQDSENIQDVIKLADQKLYQAKNDGRNCIRSTSSD
>A0A1A8TEG7|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MSNEALPLLEIVDEDSLSKVLDSFYAMIPEMAYLMDDAGQVLAKARTSPKWPAEKQSYRR
SVDVDGCQPFMICVLAHDESNGDLGLPADNISALLDILAQLISLKVSAALAKSQRRSPVH
DAPFQLKDVLQASPMAIGWSNSTTREIEYINPAFERMFGYSLAEIPTLGVWFMKAFPDEH
YRETVLMPWYEESHEAQKHGDFSKTRQLVVTCKDGSLRHVMLNVTFVGERRLVNFSDVTD
YFNIHERLEINNKLLEMVAKGDKLKDIMLALVEHVESELPDAIASVLLMDEEQRLRSYVA
PNLPNSYLKAIDGIPPGPSLGSCGTAAYRKERVVVEDIYQSTYWKGYTHLADLAAVKACW
SDPILSSSGEVLGTFALYYPYPAAPSEQSLELLNFTSNLASVAIEHRRGLHALEKRAYYD
HLTGLSNRGHFFECAGKALEGFTDEQTFYCMIMMDIDHFKQVNDRFGHKAGDKVLVKVAQ
VMLSIVDDVDLVGRIGGEEFAIMLPEVTKRQARVIAEQICQAVEQLQVEVNDDQIIKVTM
SAGIAQCCEEGECAISIDRLFGRADEALYLAKSLGRNRVEVFSKEERENAAHHHG
>A0A447IFB6|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MLKLFKTRSLRFWVALGMILSVAPLTFSAIFGYVVLNRGVIAAFHDVSERQRTELGPLQD
LRILVWDTLVPIDEHVNEGGSQRPLLYRELRGRIETGFAQVRAQFSNDPQALIHLDNATE
SWATADTHATELTAETLVADDPEAERKARLFHGHIAAVSDRLGQAYAVIAGAVQADYDNA
VGWSESATIIFAVSLGLSLLAMIGGVALVGLIMSRSVDRLVDGAARFASGDRHHRIDISV
PPELSRVAQEFNRMIARIEASETALADLARVDELTQLHNRRAFDEALARAHASYLRGSGS
ATLVTLDIDHFKQINDTHGHAAGDAVLRAFANTVRKSLRTSDQLYRIGGEEFAIILSQTE
PEMAIDLANRIREAVAAQPIAYRDQDIAITISLGLASLADGANPAEIVEAADAALYRAKS
GGRNRVVYCAGA
>A0A1A8TKW3|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MSIPFTTAFHHMPTPAFIAQIQSGEIVAANERLESLYLNVGAARQETWQSLVNDDQSSLA
DIVNKLNRGQVERISARLEVGDRFLTAEISLTELDDEYVLGYISHTEHLDFSVAENTLLK
FALTESSAGIWMWEVEGDTISCSQSIASLLGCSLEDTPHNSQAWRSRVHKDDLPKMQRTV
DEHIQHKQRYYESEYRIRRGNDEYTWVRERGRTYSQGPNAEVVKIIGFIEDISSQKALEE
HLRSQATFDELTGLLNRGAALTHFTKQLGLARRQYTPLTMAKIDLDARGLLADMPLEQRN
TAIHTSARFIYKKIREADILARVAQDKLLLLLPNTSLKDAQKLINSFLQPNDEEQKVLEF
SDASHLNLCVGLATFPEDGETIEELAQSANSAVEKGRTEGVAVFIAE
>A0A7T0DU71|diguanylate cyclase|EC 2.7.7.65|Enterobacter mori|TrEMBL
MNKNFTPKPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HNLEASLVFNDSLAANETLATLGKQGQFAAAEVLDNHKKRFAYWSWDPEDNTDTLGALIS
RWLFPEPVSQPIMHNGNAIGEIHLTARDSLISHFIWMSFAVLTGCILFASTVALTITRSL
HHGMVTAMQNITDVVHDVRTNRNFSRRVKAGRIEEFHQFGEDFNSLLDEMEEWQLKLQAT
NAQLMRTAMHDPLTGLANRAAFRNSIAALMNDASAKANSALLFLDGDNFKYINDTWGHAA
GDCVLIEIASRMVEFGDKRHLSYRLGGDEFAMVLYGVHSEPEVQRICAALSQQFTRPFDL
HNGRTALMSLSIGFALAWENVSVEALLEQADRNMYMVKNQRTKTIY
>A0A7U9LYG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O145:H28|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2X2GB05|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MKWLRKNRSGQSRPTLGRVLQRVHLGLALIAVGTAGIFLTLVALFALRAYADHNLHLIAR
SISYTVEAAVVFEDRTAAREALVLIASKEEVSEARILNNSGKVLASWRHPKDGPLHGMEE
IVAHWALPEPVILPITHEGKEVGKVWLLGHGGSLLRFLLRGMVGMIACLVLSTLCALVLS
RRMLLGIVRSLDDIANVAHAVRRDRAFGLRVPSAPIAELHELSVDFNGLLDELEAWQAHL
KQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIKPTEKLAVLFIDGDRFKEVNDSYG
HAAGDMVLTTIAGRIRAQLRESDLVARLGGDEFAVLLAPVHTTEDVLQIADNIIDCMTQP
VILPNDEAVISSLSIGIALYPEHAVTPQGLLHEADDAMYQAKHRYNGGWRLAIQK
>A0A8B5QCQ4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls712|TrEMBL
MFPNTMNDENFYQKKVVSNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPMAFSSTQLSVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A174FAN6|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MKYQIRKKLCLIISAAMLFSLLLNVLLQVNLAEKSMRTESENLFWQINQILVQNEKDVEQ
IKADFARNCLINAKAAAYIMQNRPEIIGNQPELEKIAKLLQIDEFHIFDTEGNLYAGSQP
KYFGMNFNSGEQMQFFLPMLEDRSLELCQEITPNTAESKLMQYAAVWQEDGKGIVQIGME
PDRVVEAMKRNELSYIFSIVTADEGNVICAIDPDTHKVLGSTDSNYINRDVKELGIKGEA
LADGEEGFRTEFDGEKSYCLFSRTGSVILGRICPESTMYRNISKNTLMLSLYLALLGVII
IAAISRYLDRYIVRGISSVNQKLRVITGGDLDTLVSVNTTPEFAELSEQINEMIESLLDM
PNKLSAVLDIVKIPVGIYEYRLNMKRVMATSGIRSILCLSSEETEKILSDHGLFEAKLEE
IRRCPEEAERGIYRLPWEEERYIRMDSIPYENGTLGVILDVTEDMVEKHHIVYERDRDFL
TGLYNRRAFYSRFEGIMSGKQECGQAVLFLADADGLKKVNDQYGHAGGDDYLQGIADVLL
SCPAGKKVVSRLGGDEFALLIYGAKDRAELEDYINAVQKTVSQSIVEINGQISIPVRLSA
GYAFYPEDGSDCSGLMELADKRMYEAKKSRGYKPRNKSVSS
>A0A8B4QCH1|diguanylate cyclase|EC 2.7.7.65|Kurthia zopfii|TrEMBL
MSTTKDEIADSNSNYMEIEIAKQNVARLQFISLFSIQLLFVIISINIYSHYFAKVDYNDF
KIYLPSYIFALFAHMLLLFVTQHFKHKQNFTIENARQFQKILITYIWSILITSCFISTLD
HTLYKHIVIYLVYLLSCTAFLVITLKKILPPVLISTSVLCWAIIVDDSFHSYGQGNLMLL
LTLTEIILILGYFNGRVLRSNLLQHQELLGERNRSKDLTEALQTAAHTDELTNLANRRGY
LHRMQSIDQKLPIQMTVLIIDIDFFKKYNDFYGHAYGDVVLAKVAATLHLLCAQPNRFAV
RWGGEEFLILLENHSEQEIHEFYNDFITAIEKYDIQHATSNVSEHLTFSVGGNTQFITDF
EEMNSCILHADEAQYMVKRSRKDGFLLMEEGDVIYMSDIIMQTQLRNLLASKSF
>A0A378ZUE7|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MDLATILLLYKSSLIVGAVCFAYMRCRSQEPGLDFLAAGFAVLAFSSTLAGWGEQGLVAF
IMWTMGSFAAGAGGYALIAAGLVQLSSRRRWVGDWAAGAAALALVLLVWRMEWYPDNTVR
AVLFNLTTAIFLAAAALVIFRDYLRDHLPARFGLLGALLTSIVFCVLAALALGAPGLGLP
DPRHLFFMLIICKFAIALFVVVLVQERAEAKLKRLANTDALTGVPNRQCFLASLPQHMQP
GDAFIMLDIDHFKSINDRFGHEAGDVVLTGVAQAIAGAAGPRALLGRLGGEEFCLFLRGQ
TEETAFAGAEQIRQAVKSLTFGPDAAAVTTSASLGVAVWNGAEDARALRHRADEALYLAK
QSGRDKAVLYGAA
>A0A7X8RZX0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGSIGASLLFFPGQSLNFSYTVINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGILMWLLLPKDTSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLTLSWLSMMYIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKPNMMTDIPWLPFLMILLPANMMTMVMYAFRAERKHISES
ESRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDI
EQLNMLARGEINSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECLV
PEDREYAENVIRDSLAARAPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQDSAIGIPL
LTVLHITFGENGPLMENIYSADMSRTAIEQEVVLHCRNGNSYDIQYSITSLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHSVHDTHQRHVLVFID
LDRFKAVNDSAGHAAGDALLRELSALMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRVISAINDYHFMWEGRLHRIGASAGITLIDEKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQGHDACSQLTLDEQRHTIMHNPMLMIARGVASPRIPETFSFWLLSLRLGTAE
GEAIEEQAFRAGLVDPALSKALDRRVFSEFFQNAAPAVANKGLSIALPLSAAGLLNTELI
DELLEHLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQYGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAPGNLIDEMWVSIIQGHAQRLDIKTIAGPVQLPLIMDTLSG
IGIDMIYGDIIADAQPLDLLLNTSNFAIN
>A0A0S6TIK6|diguanylate cyclase|EC 2.7.7.65|Gluconobacter frateurii NBRC 103465|TrEMBL
MPVITPPLSPDEREWQLIISAVDPEIRLIVANIVEERAPEGVEFFYRTLLTHPEAAPFLS
NQIVNDHLHSALLKWCLSLFSAFAPALSSLVATQRRIGLVHARIRVPLHVVMHGARLLKS
TLRQSLFDSALSPKDLSTAINYVENMMDLAIETMSREFVRDLQKEIETDEAYRLITLGQD
VTLEREVQRAALLDWGHKILLSICCNAPPPLPPPGIFRIRVMA
>A0A8F8MCH9|diguanylate cyclase|EC 2.7.7.65|Nosocomiicoccus ampullae|TrEMBL
MILKFILNIALIISGIYVFYRLQYHFRKGVKNKNLFQSLMMTTLAIFSLIIPLHIGDVTL
SFYYIPMLLLFLYNKIQYKLLSVVIVFMFYYFLFQYDFVQFVIFLALITIYQLIVPFIKI
PKMSITILSSGLFTVTYLILLYVLVTPISDKTLVAFFIFSLCATILVIKVYEDIDNIFTY
FINQEKYQYYDSLTSLGNVRMLDRFIDSAFKKNETVSILLIDIDNFKLFNDMQGYETGDQ
LIKQVARLLNNHIPTGGKLFRSTGEEFSMVIPDVSFDQTVRLAEAIRNSVESTKFHVDNT
HVINMTVSIGIGFKTEDKSVKKDVIREADNMLFAAKKQGQNRIMFAPIG
>A0A844CEG3|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT693|TrEMBL
MIKKNRQTEAALHSQILLVGLGLLSFVFTLYSMELTLKGTDLVPIWFTTAVTMAAFFRNP
LRRWPLIALACALGSIAASSFLYPFSLLNLTLTAINLFEALLGALLLRRFLPQQNPLQNL
NNWTCLALCSAAIPPLAGGLLVTLLPVPVDSSTLKTFLIWALSESIGALALMPAGLLFKP
YYLLRHRKASLLFETVATFAMTLALSYFSLIYLPWPFTFIIVILMWSAIRLPRLEAFIIF
LATLMMVSAMIAIGKLPLSTPHPRVLEYAPWLPFLLILLPANVITMVMYSSRKERKHITE
SETRFRNAMEYSAIGMALVSTEGKWLQVNKSLCKFLGYSGEELSNLTFQQITWPEDLNLD
LQHLSKLSSGRINSYSMEKRYYTSAGNVVWAMLTVSVVRHTDGSPLYYIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLTNDVISWDKRMFELYDIPPHTKPTYPLWLERL
VKEDLAHAEAVIRESLKNRLPFKLEFRIHVKDGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNITFMNPVAEKLSGWAQEDAIGQH
ILAILRITFGDNGPVMENIHSGDFARTAIEQDVVLHCRNGGSYDIHYTITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFESHLKRMLQGAIEQRQHHALVFI
DLDRFKAVNDSAGHAAGDALLRELAAMMLSMLRTGDFLARLGGDEFGLLLPDCSTENARY
ISERIIRSINDYHFMWDGRLHRIGASAGITHIDGDNAIASEVLSQADIACYASKNNGRGQ
VTVYEPHRHYMEQGRDTMPLDEQWHVINDNPILMIAMAIAPPRIPESTCFYLLSLRFWGS
EGDVINEPTFRAGLADPALHHALDRRIFSEFFDKYAAQVAMKGFGVALPVSGAGLISDTF
VNELLDWLASSHMPARLLHLTIQSDDLLTEPQRVYANLKRLRKAGCRMVLSHVGRDLELF
NTLSHHLFDYVMLDPDLILNVHCNLMDEMMVTIVHGHAQRMALQTIAGPADMPLVMDTLS
GIGLDLIYGETIVQPQPLELLLNNSYFGIN
>A0A6N2VWL5|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MGERKKKIQINSAVILLVIIALLSYFIFSFVQYYREMDQKIAAQTKHDLQTTNDTAKAAL
NSLLKDGKNWLESLAVICDIPDGTGKENWWNVVKKFDTKGMKIGVADSRGTIYYSSHKKM
DISGRQYYKVLKKQKSSISKVLFDEEEGTESIIIGVPMIKQGRFEGAICLEYSTMELGRL
LNGKDTSGMGAVLVFTRKGRMVASYEGMEKFPTMYDMLKTMKYDDPAQLHEMEANVQKGS
SGFLNYQNKGKLRMLYYELADISDWIICTLAVAELYEGTLYSLKSETFILMTKGVLITIQ
GVLITILLLFFSLQFFKIHRNEKRENTKDVLTGVINRKYFQKLLEKDLKRNKKYRACFFL
DVDDFKRINDTYGHQKGDEVLTAVARHLEKNLREKDVVSRYGGDEFTCLIYGITEKEKIR
EIAGRILREVTGKVHVNISMGITLIQDNDSYEQIIERADGALYEAKVRGKNQFMIL
>D5RQA8|diguanylate cyclase|EC 2.7.7.65|Roseomonas cervicalis ATCC 49957|TrEMBL
MSARILVVDDIAANLRLLEARLNAEYYEVALASSGPEALSRAEDWMPDIILLDVMMPGMD
GYEVCRRLKASTATAHIPVVMVTALVDASERVRGLEAGADDFLSKPVDHSTLFARLRALL
RVKQVLDAFRLRAETALDLGFEPLPPPSEQIAGASILLATEDVNEAELLTGVLAVDGVTL
RLTGTATQAWQALSEGAFDLALLSLSLDGGEGLRLASRLRAQAATRDLPVLLIADADQHG
LVLRGFELGANDHVLRPVDPNELRARVRNQLRRRRYQERLRAELDRSLELAVTDSLTGLR
NRRYIIRHLEGLLRNGPAALLMLDVDRFKAVNDTYGHGVGDIVLREVAARMKRHLRDVDV
VARFGGEEFVVAMAAATQEEAMQIADRLRLSMAENPVPVSPERRLGITASIGVALAKGGE
ALPRLMAAADAALYRAKANGRNRIELAGSADWPPQGDTA
>A0A514EPY4|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MDKPLWVRKLRRVSGPGHVVNYCFVAVLFFSTLLIWREVAVLEEAYVTNQRNNLENVAHE
MDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHDPIWSVALHNRRTLPV
YGVSDAFVDSQSMLSRHDARTGNELMAALELGYLLRLVDENRGFNEGMLYISRSGFFTGT
TLPKNAVQAQARYTHAIAAPWFTRQSQRNNPGRGVLWQTVFDGHEQNDDPVVTASVPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRFNLIASSASGNVLTLLSAREQ
AMLSYAFSHQNQGSIRLLTRYISWQKLNNFDGVLLRTHTLQEGVRGAFGSITIALTLMWL
FFTLMLIISWQVILRMVRNMSVMQKSLEWQAWHDALTRLLNRGALFDRAIAITRVCERTA
RPVSVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCIVMPD
TTLQMATAIAERIRIRIYNREILLCNDTSLRISASLGVSSSDDSAGFNFESLQSTADRRL
YLAKQNGRNRVCFNDLFLRDGMGK
>A0A011N927|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter sp. SK-11|TrEMBL
MLNATRSMAAETAAARDQLGELQTRVLDTNTELARLHEELQHASASARHDPLTDVLNRRG
LDEALAREIASMRRKAEQPLSLSLLDVDNFKQINDRLGHATGDDALIHLVQVVRQYMRPV
DTLARYGGEEFVILMPDTRLDEGMTTMRRLQRELTRNFFLAGNEKILITFSAGVAELLPD
ESGEDAIRRADQAMYLAKRAGKNRVMGT
>A0A8F7Q9X2|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MQLPSQTAISHVQQERECMIRGLFHEYIDMYASRDDRLTTRFSQNFTGFTGSWGRLIHDR
DEWIRITRQDFEQVPGPIRMEVTDVSLQDLSNEVVSVAATLRIHLPNDADLMAHHVTRLV
LVFRLEAGAWMITHCSYSVPFHGTNDDEVYPIRSLQQQNRALQALVAERTRELQESQAFY
RLLTEDAEDVHWQMDRDFIVTYISPADERLRGFQAAEVVGRPVFELLTEEAGALVRHAIN
LSAQKALPAGPTSFRKFEIQQLCKDGSLVWGEVLVKPDLNAKGEVVGYHGITRNVTERKR
LEEQVRQLAFHDTLTNLANRRLLLEHLDQAMGESKRSHHYGAVIYLDLDNFKPLNDIHGH
GMGDLLLIEVGSRLKGCVRAADTVARIGGDEFVVLLRTLPPQLDEARVQAIAVAEKIRGC
LAERYVLRSAPDVPAIEHACTASIGVALFCGRDETLDSLMQRADQAMYQAKENGRNRVQL
ALTAKK
>A0A4R0FJN7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 3781|TrEMBL
MNTESIAMLAEQWKSICAGYSTTDLNDTFQFIQAHSLVLVDEFYKNIMREKEASYFLSDN
LVQNRLKATLNQWLVDCFNVPFQQNFEEMSKKQLVVGTVHARIGIPSWLIMRGVREIENK
VFHLQSFKVQKNSFVIINYIIQVLGFASEIMCRSYEVNVEKSNDIKHTYRLFSAMQDVAV
QKDKQRGSLLDWENELMFKVFSDKVNFKHPLLSKSEFGLWFIHKAAYAFTGSEQVDVIIE
RIYEIDQLNENVLACVEKDKTIQLIQHIREKNREIQHLVDQIFQVAEYIDSGNDSLTQLL
NRRYLNTIISREINFSRKNDVPLSLLAIDADYFKRINDKYGHAAGDLALQFIGEVLLESV
RGSDYAFRVGGEEFLLLLVDSDLTRAQEIAENIRKRVQETSIRTATGNSFNFTVSIGCSL
YDGHPDYQRFLDAVDTALYAAKNSGRNRVYLAQNKVTGC
>A0A2N5CHZ5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pauculus|TrEMBL
MSWRKLLPRPRWLPRAALMHPHRVVIVGFGLAMLLMLIVGARDLYLLRERVLSSRQHELT
LRALGGEAVFAAERSKLIFVRDYAQQLITLYDSGAAQTDPAVERAFAQRNDRIWQMDVPL
GDSPVIGTAPALLDELEGFQRRDADLRADLYAARQLSHVLGLSLRLRDGEDANGTVSYIS
SNGLYVTYPPLALDKAPALFKRFSHISYYRDMLPERDAARDIRWTRVYTQFESTQLRTTL
SIPVYVADRFRGVVAVDVELSRLRDLIGVPEDAGTTRFLMDYRGGIIASSQHNVRIDMRW
PDDVGPAWRGVPPQELFQSGAGIRHVDDQYLIYQPVGQRGNWLMVETFSNTDVWRAVLQR
TSTPLLSIWLALPLLMFITLRVVTLLFRHYVAAGETLQRLAETDPLTALANRRHFGEAFA
RESARRQRERGSAARDDGATDGGPVDASTASPLSMLMIDIDFFKRVNDRWGHASGDHVLV
ALADVLRRNLREVDLPARLGGEEFAVLLPQTTLADAMATAERLRAAVQGTAVAPAPDAPP
PGEGDGPIHFTVSIGVAEAESDDCRTLDAMLATADRRLYAAKQAGRNQVCAADAPAGNTV
APTVQG
>A0A1X3LYW3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA249|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5P2H5E5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus pauculus|TrEMBL
MVWRKLLPRPRWLPRAAIMYPQRVVVVCFAIVMLLTLVIGAREVWKLHDRVIEERQHSLA
LRALGVGTVFTNERQRLAYLRDYAVASYARRTVPQDASDADIEAAYAARNDDTWMLPAGP
DNAPVIGVGAQRLAGLSGFARRDEALRDDLRVARGLSQMLGLLVRADKLHLNVLFISRNG
LFVVYPEQDRELAPTLVRRFDAMPYYRDLLPGRDTGDTSDEGRWIANYTQFGDGQLISTL
SIPIRTEGQFRGVIAVDVAQTRLQAMLNEGNAPDEIVYLMSRDGRLVSASQGAVASGQQW
PAGPPGDWTNVPPARLFEHRAGTLRQGAYTLLYQQTANGNWVLFEAMSPRRLFDAAVARM
SPILVVVWLLLPLLMWVTLFVVTHVFDHYLALGEKLQELAEYDPLTGLANRRHFKLLFDQ
ETERGLRHARPLALMMVDIDFFKRVNDKWGHASGDRVLAGMATRMREALRTIDVPARLGG
EEFAVLLPGATLEEAVRVAERLRTAIAGFAVTPAPDAPAVARAEGDGNIHFTISIGVVEA
GARDGTTLDVLLANADRRLYAAKAGGRNRTVSTDEAMAAQA
>A0A8B6ITA8|diguanylate cyclase|EC 2.7.7.65|Klebsiella africana|TrEMBL
MSDFILARVSQTLAAEQSLETLVRQLLEMLEAVTRMESTYLTRIDTIAQRQQIMFAHNSS
EMQIPEGFSVPWNESLCKRALEDQCTFCNDVARRWHSCIAAQELGIATFFSIPVRLADGS
LFGTLCATSRQQQPYNLEGEQVMGLFAKLISHYVEKDTLVQQLQAANVALELHSSTDELT
QLPNRRALFKQLALRFAAARAQQQLVTLIFIDLDGFKAINDRFGHPCGDSFLVQVGERLT
AVARREDIVGRLGGDEFLIVGSAQDSAAQQTYVAALRDALCGVYSLGAQRIDYAGASFGV
ITCDPQSIDVEAALRAADEAMYLDKKSRRQENFIHID
>A0A173R2Y6|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MGFHVQQEIVGIVMIAIMFFLSFVALTTGIYLKHFKLNSTRFLNIAAFLALSGIWFLSDS
ALAQEYTSFPALTGMISFYAFMLMSVPMVHFVKNTLKFEKYKVLDVINLLFYANALIQGI
LNKCLKIHMVHMLFVTHVLLFIAVITIVVLMIEEYRRTKDSELKIIMNAFGIMAVAGVLS
LCMYWKLEIPFYGTIFEVGVLIFEQLLLTSIFVNLVEQAKTRSELEVYERLLKEDRMTGI
NNRTAFEEQLQDIEDHAQDYDNAALIFMDVDGLKNTNDLYGHNAGDELIISAALCIKNVF
ATYGKCYRIGGDEFCVLIFDSIENMDELLKQMDQEIIKYNRNNRYYLSITRGVSFLKDTE
GKQKKISDWKYEADQDMYCNKKRRNINDRL
>A0A0Q0KM75|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MIKFISIAVFAFLFIGSAWANEVVTNASLSTEEMLREADSLRTKKPKRFNTLINALKARE
VELNLAQKDYFNYLKGYQLAFNGEYKKAESIWVELSESNSSLELRFRANLSLINIFAYTK
RWNEGLKYLEQNISNLHLIKDQTISNLGISAASIFYNQIGQYDLGLSYAQKLDSLSLHGR
DLCVAKHQIVESKYHLGQLDVDSEDIKLAIESCFISDEIVWLNLINIFIAKQLVDEQKFR
EVIDLLESNISDIKRLKYVPSLFQFYALLSQSYYGTGQFTEAQNFANKTIELSVGMENTE
SEIVAFEVLYKVAVKENNFEEALKYYIKFAEADKAFFDDLKTKYLAFQLAQHKAVEQKVQ
IELLNKQNKLLQASQRLAESETENNRLFMALLIMVISLLSLASIRAKQTQKRLKRLAQYD
SLTQIFNRGHFTSAAQEAITACQKNQDTISCILFDLDNFKGINDKHGHGCGDWVLKHVAS
TCDDLKRKQDIFARIGGEEFCVVLSNCNAEMAMNIAEDYRKAIAALDSSPSGYEFPISAS
FGVTDSQQSDYSLEALTSNADSAMYLAKHTGRNRVCNYADVESAKDADGVMI
>A0A5Y6MAX8|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQSFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A173SGC3|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKQIKWKHLKFEKYVFVLLLAIELIMSFTFLGFIHIDPISLTTAYIPIVVAGCLLGPLES
TLIGLVFGLASMYKASALYVVSDDKIFSPLYSGNPIGSILLSVGSRVLFGFVIGYLFSII
KGRKYEKIGIWILSLISQWIHAFLVFIVMGACFPQLGYTGMSTFHMGINDALIALCCLFW
VEVAYKIYHKERIQKYKDAVNQSLDDPYLSSKIVAISSGISFLIICIAIFSTGYFANRST
CMLKQHRVHVTRTIEIDLLHLQVQFLIAMLALDFILILTMLMIYQYMKYREYQGEIDFLT
GVMGRRLFLQHCQNIQSDQRIHGHQGWFLFLDVDWFKQINDKLGHIAGDETLKQFATFLQ
EQFEPYGAVGRVGGDEFAVMIEEEMSQEVLEKELEQFFQNISGIQKEVTVSSSIGVYRFK
YPKTIKELLTKTDEILYEAKANGRGCFVIR
>A0A702LRS0|diguanylate cyclase|EC 2.7.7.65|Salmonella houtenae|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A7M2V8K0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. BDA59-3|TrEMBL
MFPIMMNDNNFYATESGKERRSALHDDDPHSMGLQFAQRERLPRAVGLACLFMPLAGVLV
LQPVAGGWWILLVLWTFVWPHLAWQLAARSSDPYASETHNLKADALLAGMWMGLIGVNLL
PSIAMAMVVFITTMGAGGPRLCLAGVILMVVACLVTLQLTGIAIAPDSPSLIICLTVPVL
LLYPLLFSWMTFRNAARLEEHKRRLQVMSIRDGMTGVYNRRHWESLLRDEFDDCRRHQRI
ATLLLIDVDHFKTINDTWGHDVGDEAIIAITRHLQLTLRGSDLIGRFGGDEFAVIMCGTP
PENAIAAMERVHDRLTAFRLPSAPQLALQISVGVAPLTDEMTHYREWLKSADLALYKAKK
AGRNRTEVAA
>A0A1C9WC79|diguanylate cyclase|EC 2.7.7.65|Microbulbifer aggregans|TrEMBL
MTLLRHIWLPLLLVFLVVAQWQRWLALQLPLNVLLAAGLAAIAFTLGIFFKASRIATAAL
MTLLLLAGLHYLQWAPSERELRFWLSVGALNVALVSLTRDRSLLSFFGLILAALLAAQVA
GIQFMLQECCGDLLATSWSPAVGLPLLDSLFGRLELADLLIISALATAAVAVFWHRDQVS
IGLFGAGILVGVAYLGGPGMLLLVVSAIGLLLVLLALRTAYDLAFRDELTGIPSRRAYSR
YLLTLGRNFSIAVVDIDHFKKLNDRHGHQVGDQALRMVAARIARYGGGRAFRYGGEEFVI
VIRGKDRERAEKALERMREKIAAYPMRIRAVGRPKDGGGKVRKQRGQGGGRKIRATVSVG
LAASGPKARTPDQVLEAADKALYRAKRGGRNRVISAA
>A0A5T7PL48|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMPLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U5GLW5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRIYAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHAAAEKLQELADRNMYQAKHRRAERSLN
>A0A5V5HGE3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379QPF8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPSHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNVDRLLFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYISRS
GFYLSTLPTAFGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQTYIADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTRYVSWERLDHFDGLLLRVHTFREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVRNMFVLQHSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A622TN22|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKETLVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V5FB66|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MNLRTRFLLLISALIVVGSVSAWAVFHHLARQIVMQWGQRVADIQVRYDRARLLQPLERE
IALARQMADSLVLKRWARSPVDPALEAEAVREMENFRRNFSSGNYFVALRTSGAYYHNNA
GDEFAGRQLRYHLDPAKPADAWFYKLVQVGPDFHLNVNPDAELGVTKLWIDVLIRDGDEI
LGVVGTGIELTRFLDEIVDLHQDGVSTLFADLSGAIQLHRDAKLIDFASLVKPEGQKSLA
DQLLDRESDRVALRETMSALAASGDGVPRVLDRFVESGGRRTLLGIAFVPEIGWYEITLL
DLDVLMPVAALTPVAVAFVLTLLVALVLVHLVLRRLILDPLGRLEQAMLRVRDGDLSPAP
LAQASGEIGRLTQHFEAMAGAIRAHTAELEAKVRERTDALHRLARIDPLTNLTNRRGMSE
MLEAEIIRAERQASRFGLLWLDVDHFKEINDRRGHGAGDEALTRLARVLEGCLRPYDRAA
RWGGDEFLVLLSPCDAATLEAIAHRVRADIEHGSAACGERVTVTIGACLAEPGETLGVVL
QHADDALYRAKDAGRNQVVIAAR
>A0A663BII8|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MNKDFSQTSRPTFKRALRRISVISVVISMTLVWLLLSTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEETLASLGKQGQISQAIVLNGQKQPFAAWRHEPLANKEQVSGLIS
KWLFPEPTVQPIWHQGKQIGELRLTALDELISHFLGISILVLTGSILLASFIGLLLTHSL
HRGIVAALQSITAVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNALAELMKNEVDHQTSALLFLDGDNFKLINDNWGHAA
GDKVLMEVASRLMTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALSEQFLPPFNL
HNGHSATLSLSVGYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A5B9Q1B8|diguanylate cyclase|EC 2.7.7.65|Bythopirellula goksoeyrii|TrEMBL
MSESNTEIQEPPVPEVSQAKSSRLTSTESRVAEISSLLRALEDVAGGSGLVKHNEDVKPH
PTARHENKLVQVRLGMASGLFTALRQKHPQTAEHSLRVSLGCSSWALYAGLDEATRDIIE
VAALLHDIGKIGVPDSILTKSSRLTPEEESLVRKQCRQGSSIVAECCGSTEVLQAIMHST
SRFDGGDDEQALRGEGIPLAARMIAIVDAFDSMTTDQVYRDAWSRDRALQELFEHSGTQF
DSVLVKQFQEVLSEHHDVLTERVATRWLNELNNTQDELPWDAVQNAESPVPTKQGSASEN
SGRSLFEQKLIEAMRDGVVFVDVQAKITLWNKGAEQITGISRGAATGRTFAPSLLEMCSH
GKRRIHDGSCPVARVLRTSSQIRQRLMILGRQGKLVPIDLHAIPVIGRDGAILGATILLH
DAQSEATLEEKCEALHAEVTRDPLTKVANRAEFDRMQALFIEAHEQAHHPCSLIMIDIDH
FKSINDTHGHQAGDEAIITVAGLLSSMCRTGDLVARYGGEEFAVLCADCNNAHAARRAEE
IRRKLAETSHSQLGDKKITASFGVTELQAGDNSETMLRRADRALLMAKEQGRNQVVQLGN
GMEKQPTKKKWWWLGRFSGKPVIETSLSTAVPIDIAIAKLRGFVSDHQAKIVSTKENTVE
LEIASSKVSCDRRRGDRNIDYRIELEFSEQRVMRTNNLGFAAGEYTSTNIEVAVRPRSTS
NRRSGDVADRAQMILQSVKAYLMAKEEHELIEESQLLVL
>A0A5C6DGR1|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MNVLLVVLIQEFIASFRLAVALVCVGVSLILGGQWLGFVPNAELVEAKGRQALCESIAIN
ASGHLRHKQWVDLKTMMRTQVERNDQLLSIGLRSDMGTLRLDTGHHAEMWPKSDDEATRV
LAIRVPITLNRRPWGDVEFCFRQSATSAFSPLSENSVYRLVAFFALAGLGSYTLFVARIM
GVFSRTQVVPDRVRQALDTLAEGLLVLDEEGRIILANRAFATTVGMDNEELTFKTAADLA
WSFPSTDRTDPVYPWVGAIAGGELQSDCILHYRLPDGRNRIFSVNAAPLGGDEKSRGALA
TFRDVTHVEEHREELEKMLGLLRNSRDEIEKKNGELEILATQDALTGCLNRRAFFERFET
LWADAKANKTTLSCIMIDNDHFKNVNDTYGHHIGDEVLRRVSALIRKRHQHHGLVCRYGG
EEFCVVLPNLSLREAINEAEQTREAISQIVFDDPAELTLTASLGVSELRFNPSDTQELIN
QADCCLYVAKREGRNRVICYNNTMQQESEEAAKPLERVKAKQLNVSYQAVTGLMSALSYR
DAKTAEHGRRVADLCSRVADQILDPAHTYLIEVAALLHEIGKIGVPDSLLLKSDKWSASD
LQILDRHNHNGLEIIAGAFNCKELTALIRAYYQYQRRGMEADAELAKDPHLDERIRWSAK
LLVIADNYDSMVSGTGSLRDKSHAEAMAYLRRDTGNKYDAAVVAHFIDAMENRVPTLAAG
AFSIGKQAAIQIGMDVERLTMAITKQDLGELKLYVDSLATTADQIGVDSIAFAARQIDMN
TEEDERLLIDIHTLLDIARNAQTEFLRESLELKSQLTAET
>A0A846ZN52|diguanylate cyclase|EC 2.7.7.65|Oleiagrimonas citrea|TrEMBL
MLSIGREQLQSVASQLKQALYNHEHWHKDIIRTIVCGLNHDQRDVAPDAHKLCRFGQWYY
SDVTENLREHQAFTAMEFEHKRMHQIAAHMLQEVDAGHAIEVTEYDNFASALDRLRLELM
SMNREIDESLYRTDTLTGAENRTGMLAALREMQALVFRMSQSCTLAMLDIDHFKNVNDTY
GHIVGDDVLAGSVRVIRDILRPYDRIFRFGGEEFLIVLPYTNIEAGWDITERLRRKLADS
VLTTVNGADVKVTVSIGLAELDASLNVELSIDRADHAMFAAKNGGRNRTCKWEASMDLEA
EIPKHPVEK
>A0A5C6E3E1|diguanylate cyclase|EC 2.7.7.65|Novipirellula aureliae|TrEMBL
MLKLYLSSLRLAVALVLFGVSFVIAVKHLGFLPESIQGNGRLLIRFVALSILGGIGAYAM
VASQIMNSFKVTEVVAARVRRSLDAFAEGLIILDENERIVLANRSAAETFNKKQDDLIGL
RASSLSWIAASKTNPWIQAAETFAPQVDQRMRFNHPDGRESSFSVNASPIEASDSIPSGV
LVTFRDVTDEEAQRAEIEETLNSLRHTHDEIRIRNHELQILASHDALTGCLNRRALFEFF
DEAWARRHQHPGSLACLMFDNDHFKQVNDTYGHQVGDTVLTRVADVLKEAFVSPAVVCRY
GGEEFCVLMENVMLPEVLAAAESARQQIEALRFEHPAELRITISIGISLSDFGSADIQEL
IHQSDQCLYVAKEHGRNQVVVFDERVKMEEAPGSCRAADSPRAEPRCETVRGIVALLETL
DQDAESPLHQA
>A0A087CAM7|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium mongoliense DSM 21395|TrEMBL
MFNSPTRQTRSRTILVVEDEPDLATAIAQRIAANGWTARVASDGASAVRAASQLKPDLVI
MDIMLPVMDGIEATKRIVAERPVPVLMLTARDAESDKVMGLGAGADDYMTKPFSPRELIA
RCEALLRRVERATIIAKNLENEKILDFGSLVIDPRQRIVTLDGDQVHLTPTEFDLLATLA
RRPQSVFKREKLLEEVWDWPDASGTRTVDSHVKALRHKLGSDLIRTAHGVGYAFEPPQTG
VSAHTTEDAR
>A0A4Q9UVY6|diguanylate cyclase|EC 2.7.7.65|Azotobacter chroococcum subsp. isscasi|TrEMBL
MPSTSPEQQAVEWKLLLAQFPAPVAAQVRELATTHQAELAGYFYEQMLQDEQAMLFLTHE
QVKSRLHGTLQQWIASLFSSTGDETALLALIAQQKQIGEIHARIKIPIHLVLRGARHLRE
RLFDLLCRQPLDTGHKLFGQRLIGETIDLAMEIMSRAFSDANDRNSRSEEGYRLFSVAQH
IGVEQERQRSALLDWENQLMFDLAVGQFSAQLPRLSGSEFGLWFRHKGAHAFQGSRETEL
ILQGMQQIDEVLLPLFERAAAQPNVEQRLHNLRTLREQAKGIVFHLDNLFEQANVLESGR
DVLTRMLNRKFLPVILAKEVAYARQSERTFAVLAVDIDHFKQINDEFGHEAGDQVLQQLA
TLLSNHCRGGDYVFRMGGEEFLVLLVDVNQGQALGVAEKLRQQAEKERFRLPGERDLQLT
VSIGLALHDGHPDYQRLLRQADRALYEAKHGGRNRVMLARELPG
>A0A290HWQ4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MKRIPRILLKKPILLGSITFVVNLVISMSPVLYLHGKHVEHYKSIPSFNTQLLIEEQDIV
YSALLYSFIFAFIISILITLLAFFFKKSYLEVENLSHFDGLTGLYNRLMFMNVFQKEIQK
VKRNRDYLFLVILDIDDFKPINDTYGHLIGDEAIKITASTLQQLLRASESIARFGGDEFI
ISIVDQDKNAASTIVNRILNEFNNKTIPVSRNHDQQELQINLSIGYTLYRSDDDFKTMLQ
RADQALYISKEAGKNTATFLA
>A0A290HB24|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MARLKLLSKSFLFALLILVCGVSFSGYLAWKSATWIQTLENERFTTATKQTALLIRNKLN
ENIQLLHSAVAFITASDNVTREEWYFFTKEHTLETSFIGQEGLVYAPRIKINERTQHEEL
MHAEGLTHYQIHPKTSNADAYPIVLIEPFNERNKKALGFDLFSETTRQNAIKEAIQKRDI
AISSKIQLIQRADSELNAGFIIVHPIYTKDILIKTPEKQDDAFIGIVSIAINAQKLFMDV
LGARYITLDFEIYDGDTLLETEKLYDSNPSMKTARLEHNLLIDIYGKHWTLHFKTNEALD
LGISQYLPWIELFFGIAFSFILAGWIYALQQTQKKAYAIAADKTKLLAKSESKIRTIFQT
MQEGIIVLDKERIIIECNLAAQGMLGFSKSEIVGKSSNDLNWNFIHEDGSAFHMEDRPYY
KVFMTGVPQSNIMIGMKRQDSLVLWLKMNAQPLYSDDFKDVNSVLITFSDITEYQKSKRE
LEKYLQIIDAHVIISSTDLHGIITEVSEAFCKISGYSQEELIGRSHNIVRHPDMPTTLYK
EMWSALKKGISWSGEIKNRRKDGSDYWIETIIEPRYDEEYSLVGFTAIRHDITDKKRVEE
LSITDRLTGLYNRLKLDELFASYLSITKRHQTPFSIVLLDIDKFKSVNDTYGHQVGDSLL
QEIAKLLKTNVRFEDAVGRWGGEEFLILLPNSNSEDARLLAEKLRGVIEAEDFAYVGSRT
ASFGVATYHQNDDEKSMTARADEALYLAKENGRNRVEVEIHTCNLPSSSTPS
>A0A1V6H200|diguanylate cyclase|EC 2.7.7.65|Thermotogae bacterium ADurb.Bin062|TrEMBL
MSETNNAKRNFFPIILFSICVVLFLFFQVHQIVIQEIISSKTPIWWLMVLLAFSYFADNL
RLKHKGMYITTIFLPLLTLMLWTGPYTACFFTAFLSLFRLNQVKLPFFAGANRYLFRFSV
HFLMFFVPIIVFQVSIPFFLQLALYIVLAEITNVLLINIVTPVIEPGKKKISKEVLSLFL
IETALQLMVIPYLSLMKALITYEFSYAKAFFYMIPLVHLLYYGMIRFHAGYTAGLEEHRK
LDRMRVGLENMLGIVRTIRTTDDRVSILKNALTLFAQTMGYEKAIISLINFEESKINRIA
SYGIDDADFKAISRMNALRPFYDIAFQDRFLFGETYFIPEEADPFSGAESPIYVFPGQKI
WIKKKNLPLWKPKDLFIVPFFNEKQEVIGYVSLDNPISGERPTIEDAQLAKIFSDQISRI
VEASNEYQIVLEKSKRDMMTGLYNHSTFFDILQEKIREADFKHPLSLILFDIDDFKKYND
AYGHQAGDKVIIRVAEIMKQSVPYNAYLSRYGGEEFALLLPETGKLAAIRQGDLILSRIS
SEVIHEKPITLSAGVATAPEDGFQPSTIVSSADNSLYRAKRTGKNRIIAS
>A0A5M9IRE5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MTAVKVRPTLRSVIDRGHLILALVAVILASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVAQAEVFNANGRLLAQWVRPETGMLSKVELQLAHAL
LEQPISQPIIHQGRTVGSIHLTGHGGSLLRFLLSGLAGILICTVLSVWVALHLARRLLRG
ITGPLHSLAAVAHAARMERDFDRRVPPAQIAELDSLGNDFNALLGEMEAWQSHLQSENET
LAHQANHDSLTGLPNRAFFEGRLIRALRSAAKSKEQVAVLYLDSDRFKEINDSFGHAAGD
AVLVAVAKRVRAQLREDDLVARLGGDEFAILLSPLHKLEDAERIADKIIASMDMPIPVPG
NTQVLTSLSIGIAIYPEHGATPGALLNAADAAMYQAKRLSQGGQQTAEPERPAVNVHHRS
>A0A0G3Q6J0|diguanylate cyclase|EC 2.7.7.65|Phytobacter ursingii|TrEMBL
MGQEKVVKSPPRLAFVKTWFVPSRVVNLCFVIVLVCSTVLTWREVIVMKGAYVVSQRNAL
DNVANVLDRQMQVGIDRLLFFRNGMQSALQTPLAFDVLRNIQAEFEQKRMLPYWQIVLDN
RRTLPLYGVSDYFVEQSASLSRDNPLLHNELTAAMELGYLFRFASSATMFPRRALYVSRA
GFFISTLPVGNNNEIVQQYYQYLTSPWFSGQSERENKLRGVRWFSDEAHELSLADSLVTA
SVPLDYENNWYGVLSMSFPVSSMKALLTEARQNQDRGEYQLYDAQFALLTTTAERGTANQ
QFSSEERAQLKREMAKDTAGGLRLGTRFVSWEKLKHFEGSVLRIQTLREGLRGDFGSISL
ALALLWLLFTTLLLLSWGVIRQMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERARVLT
KECAAQNLPLSVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEE
FCVLLPGATLLDATVVAEKIRQRISDKEIFVQKSKTIRVTASLGVSGAQEGGNYDFEYLQ
SVADSRLYQAKNNGRNQVCAEDGVSPLPNT
>A0A1S8L6P6|diguanylate cyclase|EC 2.7.7.65|Clostridium felsineum DSM 794|TrEMBL
MGRINDFLSSFLYIETFSIIVIAIYSWRRRKALGAFPLLFLCFSSAIYSFGYGMEITSTS
LESVNLCSKFEYMGLSFIPVLWVIQAYSLANKDKKISNIIKVLIFIIPTLTCIFRIANDK
LNFMYRNEKLISNGYFYILTYEKCFWYYIYYSFFFGCIVISTIMYYKAFLKASGLARRQL
KIIICISISAILFEGFDQLQIVPIKMDYGAFIMFFVYVLFAAAVYPFDIMHIIPVSREII
FDWIYDGVIVMDTNFNLKDFNYAAKEIFKCLDKSLIGTKLELCTSEACEFMKMIKIWYSG
SEECSKKLLDGGFIKDTFEFRINSKGSVIYFKARLKALYYHGYRVGSTILISNVTKEKEE
VLELEKMARFDQLTGLLSRAYFTKYSNVEFDKLHRKNQTGVLVMIDIDYFKRINDTYGHQ
AGDHILKEMAFIAKNMLRNKDLIGRYGGEEFIAFLPQLSLKQAKLAIECIRLAFQNHDFF
YEDKLIKVTASFGMVECCKRTMANSYEQMVKKADIALYESKKNGRNRIAVY
>A0A1N7S1E2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia piptadeniae|TrEMBL
MSDILIVHTPASGIGVVTRAYARLLIAGFALLPAGAIAYLAGVQAPSLTFENHAFHEVAI
AAATAEGAFVTYVTWRCYRSSGEPLLRWLTLGFLGFVLIYTLHGAFTGLAHHHMWLFLLY
GPASRLAMAVLLLVGLLSFGRQPDEAGTRTNIRLWGTWIAAFVLIDAFVAAVASTTIASV
GLIRSLESAALLFSALNVTALMVRRIRSPLMVTFGISVTWFALSSLAFLLGRPWNHMWWL
AHLIFAGGFFLLSYAVVQAFHTTRSFATVYSQEVMIARLAAASIRTERALEELQRTNQKL
EHLAATDPLTGAVNRRYFIVRVEEEIARAKRDGTPFSLLALDLDNFKAINDSYGHQAGDV
VLQSFVQKCVEVIGPYEGVARMGGEEFMILLPQTRLDVASTIAGLIRATIAGRQFEAAPG
EQIALTVSIGVAQFGPDGDSIDMIFRTADQRLYCAKGEGRNRVVAA
>A0A0F0CBN5|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MGLFIFDTMGGSKVQNPIFALITSSAINILMLLILLYLILKNTVMSVGKTKAYIAVIILT
VIVIIAELSTSVLDLLGATFRIPNIIANIVGFSLSTCIPVLLAMVFDEKLYGKLKCICMP
IALNFVLLISSAWTGWIFFISMDNQYTRGPLFGIYIITYLCGLVVLMISNHHQLLQFQDT
ERAFLMMLYAIFFIGTTVQILFPFIHSTWHCITLVLVMYYLFQRELQFKYDIVAEVLNRQ
AFDKKLKAISATDHSGIILFDLDGFKKINDTYGHAKGDYYLKTAAGIIKNSFKDIGQCYR
IGGDEFCVLAQNTSEGAIHECINLMLQSLKKTREADTIMPIISYGYSIYSKGEQRDILLS
FQEADKKMYTCKKNRRIEFLL
>A0A5P9BFD5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MTNRSSKQWSARILSCLFLLTTISAVEFFHQKQITFLKNEAFAEAQKQLAVVRSRIEAVI
VTDMYLLNGMSTQVAIAPRGSVEEWNKIADSIIQDGSHIQLIGLAQNDVLSFVYPRKGNE
SILGIDYRDHPEQWLSIVLARQLGKTFISGPVELFQGGWALITRTPIFMDPPFNREYWGV
SSAVISLESLLKDAGAEQLESRYHFAIRGFNSTGKDGDVFYGDESVFESAFATEMASFPY
GGWFLALSGEDKVLMDVSWIRINIMRIIGYSVLFLLSLAFFTIYRLYTVAHGRAMHDELT
MLPNRRYFMYSLKMAFRDAKSSGSERFAVMNIDLDGFKSINDTYGHAAGDKVLVEVSKRI
RAVLRSSDIVARMGGDEFLILLPRVHDDQNLLSIRSKLERDICLRPVEFDGQEIALNASI
GWVAYTEAFNDVDELLKAADEKMYQRKRAS
>A0A5P9BFK0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MTSVIGHRINLRLLVLSLCILSVAITLMNVFHSSYRAQHELIINKSLEANRVYADKMAAM
TDVYVEQVMTQLKYSARLLSSRVNDANFVAQETTRLKQQTDSFNSVYVVDHDGVIASIMP
TSVNIQGVKLTSERSRQSIRAKAPLISDPFVSPAGNYLISMTYPIFSPQGRYLGYVGGSI
YLEDSSLLSNLLSRHNYKDGSYLYVVDRNRSLIYHPEKNRIGEVVLGNDAVEAVLNVGDG
SKGIVNTQGVAMLSGFAMVKSTGWGIIAQTPKDRAIMELETQMQYVMFESIPVGIGTLIF
IWISAICISRPLWQLANTVNKFDTTHSLSTELSNVNPWYFEASQLKVSCENTFNLVSNQI
EKLHSENLTDPMTGLLNRRGLKRAIENFQQSEKPVSVLALDIDHFKAVNDKYGHQFGDQL
LKQTAKLMKAQVRDVDVVCRSGGEEFIIFLDGSNMDVAYEIAERIRLSIESDITSLEEGT
TISIGVAQWYGDSTPISLTLELADNALYAAKRNGRNRTELFS
>A0A090DDU3|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp. ORS 3324|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTAGNGPDAIDTCENGKVDVVLLDVMMPGMD
GFEVCKRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRNFATEDTKPKVLLIDERKSSIERIQKMLRGSAE
LDVATDPNAGFFQAAETAYECVLISTGFADFDALRLCSQLRSLDRTRFLPIILLADEGEE
GRIIRGLELGINDYLTRPIDQHELTARLRTQVRRKRYNDQLRASVTQTIEMAVTDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDTHGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGPIAEKVAERIRAEIAQVPFAIGSDGKTIEVTVSVGV
SSVLKGADTVAALMKRADLALYEAKSGGRNRVVAKAA
>A0A511UIK5|diguanylate cyclase|EC 2.7.7.65|Halovibrio variabilis|TrEMBL
MRYKDKYQLAAEWQTLLERTSKPLRQAVETLVESRCGFFADHFYTVMLDDPHAALFLSND
QVEQRLNPSMRRWLQAMFAVEHADFNALVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YQQINATFKSPLSPGDASVYVSEHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIATQQNIATLPRLSNSEFGLWYFHKACHAFQGAPEIATIT
RHIQQVDREWLEVLLHEDSRQRLQALSDIRDAARTVLMLLDDVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIEMARHSENCFALLMVDIDHFKSINDTHGHDAGDSVLQQMASILDRS
TRGGDYVFRMGGEEFLIVLVDTDAEGSRLFAERLRQAVAKEPMLAAADTLLNVTVSIGLT
LYDGHPDYQRSMQRADQALYQAKRSGRDRVVVKQ
>A0A173S5R9|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKLKNKKSRNIIGIIQSCLIFALVILVIFMMIQINRLQGTARVINYAGLVRGATQREVKL
EITGSQNDELIKYLDDILSGLKYQDGNYDLIKLQDKEYQDKLQVQIDYWNKIKKEIEAVR
SNGYENTDIVNMSETYFKLADDTVSAAENYSEKIATKIRTIELLSVLDMLCLVILIIVQT
IMAMKMARQNKLLEQRAYTDARTGLPNRSACKEILNNNEIISSPTACIIFDLNNLKFIND
TMGHSAGDRLIVKFAGLLRRVFPEKDFVGRYGGDEFMVVIYDTDKAEVDEILKCLCLEKD
KLNNTGNELQIDYACGWAISEDYKESTLQILFDSADSYMYENKQLCKKQNQ
>A0A173XMR5|diguanylate cyclase|EC 2.7.7.65|[Eubacterium] rectale|TrEMBL
MKNKRRFAMVSVSVIVVALILEAGILKYVNDANAYRLSKVLLDRVVTVLNKNDQSEEELI
ESLKDDYIVRAKAVSYIVDAKPQVENDVEELQKIAKLMSVDEIHLFDETGCITSGSVPKY
FGYSFDSGTQMSYFKPMLTDKSLTMCQDVTPNTSEGKAMMYAITWNEAGTMMVQVGLKPQ
RLLDELKQNEISTVVSDMPVYKGMEIYVADADTGLVKGATDCDKIGKNFHDLGLPTDIKE
SDKPTVRQISVNDSGCRCVIRRGDKYIVAVTIDKSFYMTNSVVALLVVGIYLILASCCIM
YMFSKIMKEKYEKEKLLYISNTDALTGCLNRHAYETDINKLDLKKEWIYISLDLNSLKHI
NDTYGHDVGDEMICAAAACMMASFGEFGKVYRIGGDEFVVIVTQKPDELDTMTKHFDSSV
AEWRGKIVNSMTISYGCVRSLEEDWELVHDIEKEADRRMYASKARYYSDSGIDRRK
>A0A3G8JUA5|diguanylate cyclase|EC 2.7.7.65|Gordonia insulae|TrEMBL
MLRRYDARSMATLISTGGVLPLPIFAVVAPTTLRPGGLIPLLVIWCFIATAFTVTACRHR
LTDWQFAVLGGFGIIGICGTSLILANPRPSIAVLGLVAVIPTIAAMSPVLPVSLSLTAMA
VVGSTTVLAVTTVSIPAFIISVGAMIGSITVPVFLVVALRRSLEMTLDRQTRLSGIDPLT
GLLNRRGFLARVSQLLAAVRVSTGWVGILLMDIDHFKKINDQYGHLAGDGVLLSTAAAIR
EVAPAGSVVCRFGGEEFLVFCVARDEDELRRCAEQFRAAVAEIAPVTMSVGGVCAPLVTS
TRSNAPSTDDVIGRLLGRADDCVYRAKEQGRDIAVVESMDPIVWRKPNRTVAVELNESTP
AASLFELFSRRTDESVDVQASGER
>A0A6S7APL9|diguanylate cyclase|EC 2.7.7.65|Achromobacter pestifer|TrEMBL
MDPILAGLSNSLPQAKSVEQLTRPLLDMLGSVTGLESTYLTSIDLKADVQHVRFARNVGD
LQIPEGLSVPWSDTLCKRALEEGRMCTSDVAHCWPDSDAARQLGIQTYVSAPVRTDEGML
LGTLCAASAKQHQIAPQAETVLKLFSNVIANFLERELLMEQLHAANVRLMSYALTDPLTG
LPNRRALYEELERLEKRALREGGSVLVGVIDLDGFKGINDTYGHQQGDVFLQEISRRLAS
TLRTSDMLGRIGGDEFVLIGPGPAIERGNAGPGGEALRGEAEDAARALEERATAATIGRY
QLGEAQVPYEGASVGVVAVDPRGLDAEAAVRLADARMYEIKRARKGARTLH
>A0A7L6YGE4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C01|TrEMBL
MEMYLKRMKDEWVALVEQTDPHIRKLASEIAIHHAHTLSIEFYRIVLADPHAEEFLSNEQ
VERQLKHALEKWIVDVLSCTSGDVDELIKVQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PIIIDSHHEATEKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQIASLLAWEMDIIYKIMLDADFGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGLFHQTRGTAKALNNKASRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSILIIDVDKFKEINDTWGHNTGDEILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEATQTDTLRIAERIRSRVEKTKIKSPDGEAIPLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRHGRNRVELWKPGA
>A0A7Z2FSS4|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MDKDFTSTSRPTFKRTLRRNSMISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAASETLAALGKQGQFAVAEVINAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGLTIGEIRLTARDSLISHFIWMSFAVLTGCILFAAVVAFIITQSL
HRGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQAYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFSLAWENASVEALLERADRNMYQVKNQRTKTIS
>A0A380PZ73|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVGSVLYTQHASLWLWIALAINGLIWP
HIAFILALRSEQPFEQEIINMKIDSAIGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
IFYKGLALQIACSLLTAWIFNLPFRPETSHIQVYACLPMIFIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKAINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREILTRIQEKLAGIVF
TQAPTLQLKVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A263VX45|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRESFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFDTVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTFLNRDAERLSHEISATLEVGYLLRLASSRAQTEARVIYVSRA
GFFISTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERMITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHTGNAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAILLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASTLRKNDVAGRVGGEE
FCVVLPGIGLEEARSVADRIRCRINSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADVRLYQAKQSGRNRVVWRD
>A0A4U8Q8Q4|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MKSLKTKVIALVLGCMLLSSFVIGSFSILSSKRAVSADSAQIMNLICENKTQEISALLSR
IEQSVNTLTLYASRQIESTEKFKTDSAYVDQYTEHLTDIAINAATNTEGAMTVYIRYNPE
YTSPTSGLFCSKSSTDSTFQPLEPTNLSLYDSSDTSRVGWFYEPAKNKKGTWMAPYLNDN
INIEMISFVIPFYVDDVFIGVVGMDIDFSVLQTIVDETNVYQNGYAYLTDEKANLIYHQD
LPRGTSLMDYNNGEFREAAEMLLQNSSENSLISYSYHGYQRKAAFRSLQNGMRLVLAAPI
SDIDKQANLLILQILIASFVIVALTAILTFIFTRRLVKPLLELTAAAQKIAAGDLSISIT
HHSNDEVGTLAESFRETVKHLHKYISYINELAYRDPLTGVKNKTAYLEVANKMDELARLK
RPEFAVIVFDINGLKNVNDTYGHDFGDILIADTCKIICHTFKQTPIYRIGGDEFVALLEN
DDYKNSIQLLNQLQKDIDAYNEQPHNTIKISVAKGIAVYSEATDYTFQDVFKRADNAMYY
NKAKMKSSV
>A0A2R7R0J4|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp. HMWF003|TrEMBL
MDIVPNLDEASRPLADAWQQTLQATSPDAAALLAELAARSPPDLAHHFYDVLLEDPRASR
FLSHDQVRLRLKPAMQRWLTQLLTATPDSIAALVAAQRVIGDVHARVGIPVDLVTRGTRV
LKQRLFAQIVADAPDSHVAFEAINCLSASVDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAIASQATDADTVDLAHSEFGLWFTHKGIPSFGESSE
TAQVGALVAQVDAQLHAALAHADVGARFGALQGIREQLARIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELATSASTPFSILLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRRQIAQTPAQLADGTALALTA
SIGVAAHDGHPDYERLMARAAAAMYQAKKRGRNRVVLADDAMPEAPGRQALQRG
>A0A517LVH6|diguanylate cyclase|EC 2.7.7.65|Rosistilla ulvae|TrEMBL
MSRPARVAKTAGRSQHHPETFPFWKILFCQTTNKTYAWLVPVPPPVTRYRAPYSLMIDTT
PTSPTGQSTAEPRQVDAVEGFERISTLLGDLNRLPSGTVANRSEYDADGSHENQLLSVRL
GVATSLFYSLRCKHRQTADHSLRVALGCSVWADRLQLPTELRDRLEVAALLHDIGNIATP
DRVLKKPGHLTADERLIMDQAPDVACEILRGCCNDDSLLNILRYSRNWYKAGNDSDQIQG
DDLPLGARMLAIVESFDSMTTDQVYRRAFSQERAVAELFQCAGTQFDPDLVRDYAVLLEN
RPELMYATAARRWLQELQGEFSNRFWSSSPSSSSGTTGERQTGQLLFHQHLLDTMCDGVV
AIDGEGVITHWNYAFERMTNIAADAMIGQAWSDSLVGWEDTRAPSGDSVGLSSCLRSGAQ
SRRRMRMVLPEGKETPVKVNFIPILAAENRVQGALAIVNDISQEESLEQKVQSLHVKATR
DGLTGVANRAEFDRALGDVVEFAAEGKGPASLILCDIDRFKSVNDTFGHQAGDEALISFA
EVLARHSRDGDLVARYGGEEFVLLCPGCDNATAAKRAETIRSDLERISQPALNNKCITAS
FGVTEYQSGDTESTVVARADRALYKAKENGRNRVVQLGSGLREPVDTMSDSSKGWFHWLL
TPSKSNQVVAELVTRAPVEMVIEKLRGFIADHNAEILKVQDKRLELRLDVRSSIHGRRSA
DGVSAFHLLIDLDERNVETGLHGEHSSLMETVIDASVSPWRSRDRRNREVKGACRNVIAS
LKSYLMADYVKQP
>A0A4P7NWI3|diguanylate cyclase|EC 2.7.7.65|Hydrogenovibrio crunogenus|TrEMBL
MRVWNLHHKILNLINDSETIVFYCEYAPRWPVLFLSENFSAFGYAPEKFYAQEVSYQDLI
HPNDLAGLEQAVAEQADSGAPYLSKRVRLRKSDQTYAWIDIRLTFERDDADRVTHLLGKI
MDITESVKSEEQVNLFAKVIQQTADFVKITDKAGYLVFVNQALMDKTGYTEQELIGKTPA
VLKSEMQDQEKAKTLWETILSGEVYHNRIMNRCKDGSTYYEETTISPIFNRDGEIEYFVS
TGKDVSEQVKMQQELNDLAMKDALTGLWNRRHLTEVIDAEMKRINRYGGRFGMIMFDVDY
FKQINDDFGHDIGDETLVQIAKIVQKLVSETDYIGRWGGEEFLLIALELDASLTAKLAEK
IREAIEEFVFPKVGQVTVSLGATVYHKNETEAQLFKRADEALYLAKRHGRNRVEVY
>A0A4U8Q026|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MKEIKKYLDFPFEKSYLEPIKKRLFQNVIRTHIAFQSLIIIFQLIMMLSISLRPGGPFFK
PRRTAYFSMYVILAVITLGVLIINVILAKKQSLNHHFYFQLNFFYMGFLCFWSTFVTLND
QLGGNGLNVFTYVMLTVAVLTLSKPWHNILIMGGNFLLLNCLLPYFPDPHGADQSFNNLM
NSMFTTVLAIAISTIFYRNRIMSEYNQIIITEQYNQINDINSQLHQEVLTDKLTGLYNRR
YLDDTVKNIFRNNQEEHNSAACMMLDIDFFKQYNDTYGHQAGDNCLAAISHLLSRDIKTE
DVCLIRYGGEEFLIFLFGKSSLDANEKAEVIRSSVEQGLYNTPDIPKRNMTISIGLYQES
PMKETDMERFIFRADQALYEAKKNGRNCVVEYK
>A0A6N3LUV7|diguanylate cyclase|EC 2.7.7.65|Vibrio nigripulchritudo SFn135|TrEMBL
MVAPHSLSRHYTFTLLLSGALVLLVVILYGSFLKHAEKNRFRSQLLSSSFQVHATFHDRI
EKAQNHVSVMQLAIEESLAYPVFAPNQASTFLKKYHRDSPKSSPWDNLPGELKFLLGSLH
IDPARNLPKSNFQRTLSALFPMLPEVVSVHQQSSTFQWSYFFDSGARWFWVYPAWSRSEL
LRATKSTNTAEAIRKLLRHQGMAPLDLAGPKVNPNRQQVWTEPYQDFGGKGLMISLLAPV
YSNNQYMGAVGTDLAFQMMENVFDSAPLFLGHGVVFDGRRMLLADSQNSLVERDQSVSLD
VAYPTFLEIARLVDAPAGLTETEMGVWVSLPFELTDWHFLAYVSKEQEEAYLLRQTFPYT
LLAGIVTFFLFVLAWLQHSRFVRPALRLVEFVHEVQNNPYAYPKKIPDVWKYWFKRVSQT
AIERHELLSKTRQHAHELEKKAIRDNLTSLHNRYFLEKTPPPWLQEKNRLGVLMRANINN
FKAINSVYGHRVGDELLVEIARRLRSVFGDESVIRFGNDEFVILLSGTDELSINEGRGRF
CEMMRRPITSHNMVLTVSATLGMSRYPGDGESIEELLRKANIALHEAKENRVGGLFFSDE
MEKKTKRKVLIGRELEHAVEREELSVVYQPQLDANSGEVVGVEALVRWQNAQLGNVSPVE
FIGIAEANGTIVSIGEYVLHHSMKSMSELWTQLPQSGGGLRLTHRPIRLAINVSVHQLLC
TDFPEQVIRLHRQYQEKGVTLVVEITESLFIDNVDRAVEILTSLRSSGVAVSLDDFGTGY
SSLSLLNRLPIDELKIDKSFVKGIATDKGSRTLIGSIIGIGKNLSVSVLAEGVEHAMEVE
MLKGLGCDVFQGYFFSRPLTTEQLKCFLYEQSKV
>A0A5U3E1Q2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A379WNA3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLHNGVV
DALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKNAQLL
RTALHDPLTGLPIARHFAAVLTR
>A0A3N6H5Y4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI97-07|TrEMBL
MEAESEPYVRLATMRQLHQAVADLNTARSLADTLQTVADGIVTGLGYELGCVNVVRPDGD
LVVAAFAGNSAAEALITGRVGSRDSWERRLSMGEAWDGLRFIPHTEGWVLLDDDVPQWHT
EGPEPRFEDEWHPLDRLYAPMYASGGGMDLLGVLSVDRPRNGRRPGAWGREALQMYASQA
AIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLLR
TNDALCRLLGRPASVLRRYSFADLVHPEDIGTLLRTSAEGGRAELRLGRRDSTYLWVSLR
NSVVADTADGPRFLLTHVEDIEERKRNELNLAHRASHDALTGLPNSAELRSRLSARLCER
PHSVATTAIEALDAAYGDVEVSAAHGYRADGYEAEVPGLGPYDHHVHVAAPDTERDDGAK
GLAVLFCDLDGFKSINDRFGHHTGDVVLIEVARRLTTCVRDGDTVARLGGDEFVVLADGL
GAADAADLAVRLRNAIIPPIRVDGRAVRVGASFGIGWAECGMTVEEVLRSADQRMYVEKR
SRSKVHRRAG
>A0A554XMC9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MIADPRARVRLAQLHLYVDVHRHDRYVAPVLAIITALLLSHWVPTPWALGWLVLELLIIA
HYLWVYRRFKRADPPPSEERRWANRIALAHGAHMLAWSSLVVWAWQPGDFGNLMFVMLVH
VGLISLTVSMSNAHLRLLWLDMTFPVLALIAPPLLEPSAFHLGLSLLGIGFCALMVLVGR
QINAATTEAIELRQRNEQLIQELHSQATRDALTGLINRRYLLETGARLLQQRHRSGEPLA
LLIIDLDHFKRINDQHGHLGGDEVLVAVVGTCAQHVRAGDCFGRLGGEEFALVLPDTQLA
QARDLAERLRSATAALAIPLPGVTIRPTISVGLAMATDDDTTLSDLLRRADAAMYEAKAG
GRNRVVCVDPAGGFRADPVPA
>A0A377P7Q5|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MNAKNYDDLLNSKSHMTFLLFILLNGATSFYALLNPLQTDPPYTIAGIGVFVFCLFSSIS
LIWHRDKYLLKLNVASLLLGLLWSFHIAAKYQHVDANSHEFLLINLFSIFFIAAVTLSDN
LLAFCLNAVPVAITVIVLEDFHNMTRILFVLTLPIIALSLHHAMTRRREAFTRRLVTQLE
QDRARFSDLSMIDPLTTLLNRRGLEFQFHHMGSDCDTEHKHFVIMLDIDFFKLYNDHYGH
QYGDIALKSIAQIIKEAVRTRDLAIRYGGEEFLLILRDASESLAIQICEHIRLHVEQLAL
INEYQPNGSNVVTISAGLSEMHGNNLENAITRADQALYISKQKGRNRVLLQKET
>A0A377PIB7|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MESVNDIYGLNLTGHKYPKLAGTLQTKNSSCEDWARDIKYLAKFNSQEEAISQEYSFSNY
HWKVQDSIRYYIDFENQYIYINKLVDSSRYAFNNWLRYNGKFIDVDSNARSIKIDDEALR
SLHDGQSVTSHIYDDGYTGEKIISMITPLFFGGNLKGIILTDVSINELAKAFYTFDRPFL
WKYLTLSVIDRNSAEEINFNQPDKQLFSILNYDKDITRYYTVHLKLDVQYFILNNLFLFI
LYVLITYSICKYLKYQISKNEVLSLENITDSMTGLYNRKILTQTLDARLKSLTEKNTPVT
IIALDCDKLKTINDTLGHHMGDKAITLLGDAIQTSIRKSDYGIRLGGDEFCIILIDCDVE
RAFITIDLIKQKLKVIDTDAIVNFSYGCYQMKSGDTLSDAQIKADELLYKHKKTKG
>A0A3U0EUL5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRSVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A554XFA4|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MLPGADPCQIGTIAERLRTGVAERPFELPDGAALEVTVSVGAVVALPDEDADALLMRADR
ALYAAKHAGRNQVVLDGIDPAAFADTEPSGAPALPPFPALGER
>A0A554XHK1|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MGIRFATDQLEALLRSLPDPAFVLSASGRYVAVFGGTDTRYYHDGSPLVGRTLHEVLVLA
RADGFLADIRAALHDGGLRIVEYELSNRDVLGLSDAGPAEPIWFEGRITPLPFTVDGEAV
VLWVASNITHRRQLQERLRALSETDELTGLANRRRFLVELQACFDAFARYGQPGALLYLD
LDRFKAINDQLGHERGDAALCAVAAVLDGHRRRTDLAARLGGDEFVLLCPHTGLDEARAL
AERLAAPMVQALAPFVLGGGLRASVSVGWAACEPQDASGADLVRRADAALYRVKRASRAA
VA
>A0A379WGQ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTTAEPQQARATAERIRQEVYDLKI
PHMFNESVATNVTVSIGIAP
>A0A8B6A718|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNRFVAFALGCIFIIAVLQGCFIKLVEWVPSFSPLFFPTLTIFLLVFHLFIACFMAMKYW
CDKKRLYLVPIASAFAGSALLMVGTLSSFPGWLDLYQFNEANYNDAMIFYMFRHLLMAVL
MMASALLYTLRVSPLSRSTHIGIVVGSALFTGCMLWLAWFYSSHSTTLTLDLVDNETRQF
MILWSQTINIILVILWVVTLITLMVVTRIRNLFWAGGNFLCVCYVVTLLMLLLGGYVEDV
SWYRARLFETVATLMIIFILLSDVFNLYRDSHVKYQQSYQNSIRDPLTRLYNRSYFYDSL
NYALSTATEARPVSVVVSDLDRFKRINDCYGHLQGDKVLQFVSNLLTDSVRPQDIAARIG
GEEFVLMLTNTPSDAARQVAERIRLKLSGFDKASSGGHLPEPITISMGVFTATSPETSAE
TCVESADKAMYEAKETGRNRVVVFR
>A0A6G3F2M2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVTPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIP
>A0A6L3Y0U2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDNHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAIIAGVWMGLTGFNALPTA
ALIVMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVVLTSEPLALWLTLPVLVVY
PILFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRNEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPMARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A822WF01|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MSDIILARVSETLSTEQSLDSLVRQLLEMLEIVTDMESTYLTKVDINARLQHILYARNSK
QMQIPEGFSVPWDETLCKRAIDSDTLFSNEVPDRWPECEAAKALGITTYMSVPVHLADGS
LYGTLCAASTAQKQFSERGEQVIRLFAGLIGQYIQKESLVLQLRVANAALIAHSYTDALT
GLPNRRAIFENLTTLFSLARHLNRNVMMAFIDLDDFKRINDQYGHEAGDRFLVQVGKRLT
HEQTQDEIIGRLGGDEFLVASLSHSDDGDASTEVNAIKTRLNGLIAGEYGLGNATILYPG
ASLGVVIVDPHSTDEDSALRTADLAMYQDKKGKSKTGFVALD
>A0A377DU07|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLG
SSLPLSQADFGLVV
>A0A5P0PKG9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSQLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A826MK01|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSELRFARRVRLPRAVGLAGMFLPIASTL
VSHPSPGWWWLLLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNA
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A8G7XX25|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDVHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTSALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376W695|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGIYLD
>A0A484Z3C5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRV
LIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAENLQELADHNMYQAKHQRAEKLVR
>A0A6D0FRT0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQVTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSELAAISLDEQWRMIKENQLMMIAHGIASPRLPEASNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQPLDLLVNSSYFAIN
>A0A376VLJ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQNHA
>A0A8H2GIN7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
HYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLREL
FEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGH
NTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKL
KAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A4T4I572|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFEPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8G8WST3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNTEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTERNRCMFIDEQNVINRV
>A0A3L2NSZ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERICSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A826WUG3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKPSQHVLVTLPHPLLHLVSLGLVSFIFTLFSLELSQFGNQLAPLWFPTSIMMVAFYRH
AGRMWPGIALTCSLGNIAASVLLFSTSSLNMIWTGINIVEAATGALLLRKLLPWYNPLKN
LNDWLRLAFGSAIVPPLLGGVLILLITPGDDPLRSFFIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYNQDELRALTFQQLTWPEDLNKDL
QQVEKLINGEINTYSMEKRYYNRTGDIVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EHINKRLMERITLANEAGGIGIWEWELKPDIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWMQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYRFIWEGRVHRVGASAGITLIDDNNHQAVEVMSQADIACYASKNGGRGRV
TVYEPQQADAHIERAAMSIDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWGCE
GEIFDEQTFRRSFSDPALNHALDRRVLHEFFQQTAKAIASKGLSIALPLSVTGLSSAALV
NELLEQLENSPLPPRLLHLIIPAEAVIDHAESVQKLRLAGCRIVLSQVGRDLQIFNTLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNNSYFAIN
>A0A6D0XR09|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIARIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A8H9JIY1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTRLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A447XWJ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKSLTVGATVLRHANLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAG
LIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFGKPDDAVFSRPTS
>A0A8B6B010|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSG
GSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQ
LRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLAR
LGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAA
EVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVA
SPRIPQARNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVA
SKGLSIALPLSVAGLSSTTLVNELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLA
GCRIVFSQVGRDLQIFNSLKVNMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMK
TIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A378B1J5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQLALRADFDFQTRVYSRSGLSEALK
RQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVLTQFAQQVRQLVGEQGMVARIGGEE
FAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPIHLTISLGLETREVGHAPHHRAV
>A0A5N8HL43|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWG
>A0A1L4IXL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLHDAVTEFEQHRDEHAWKIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKMCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A377DS78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRQR
>A0A377HCI7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFPGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQAGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A7B3IER9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVFLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A376MU34|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAVDVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A2X3JHG6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MACGLTIKVDIILAALPEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTV
SQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDK
FKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAER
IRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELW
KASL
>A0A2X7Q2L4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVADALYRAKNDGRNRVLAA
>W7W9R7|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MTSDFTIHLPTLMLLAVVVMGATAAIMSVFGLSQRVYRGYWWWVGAMWLATLGAALHGLR
NLWPVAVVPACLLVMVWPVLITTGLRRFFSRDRQFSSTRIDVALYVACYLGWLACWLASA
PQPIRSLAYGAGSLILLLYAAVFIGKLDDFRRSPALKLLMAVMIVQAAVPMLRLAGMFSQ
GAGALPAQSLVVTGVVLPLLLSMLFTVYLCLVLTHERTVRDLRETQRQLRVLADIDMLTQ
VPNRRHFEELATAIVGNGAAPPSVLMLFDIDHFKHVNDNHGHAVGDAALRLVARCTRDTL
RTRDVMGRVGGDEFMLLLPGASVDDALHVADRITRNLDLASKNFPLPLSLSFGWCRSKQA
NRSPPHSTAPTSPSTRPSARAAAAPCRPGRTGPIRCSVRAGRWGSIRSEVCRRRQRGANP
CRANTACPAGPSTKSTNRWARGPARSNSATP
>A0A378AAP1|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MTGLANRAAFRNALAELMQNEVDHQTSALLFLDGDNFKLINDNWGHAAGDKVLMEVASRL
MTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNLHNGHSATLSLSV
GYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A377EPX8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHMQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIA
>A0A447XWI0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDEKLLFQR
>A0A1V5QV98|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MKKLRLAEVRQVEKSFNWHSRQNFSAIFLLGGGAVFPFVLLRWQAGDGVGSALTAALVLS
FWALAAWSLSGRRIGIVPVLVMLVLCDLMTHITVMRLYQNGIFWIYPLMMAVAYVMPWRW
SIPLNMLNVIITVWHAAGWMSEDEFSRLAATLLVTWVFLSFFAFNLEQQHGILRNLVVHD
PLTGAFNRRYFERKLDEARRQWMRTGNPYSMMMIDIDHFKLVNDIHGHAMGDKVLVALVA
YLNAQLRPQDRLFRVGGEEFALLLPETSAAQAVQLAECILKTLAAASLARGLPRFTVSAG
VAELPARSPLSEWQTRCDAALYAAKGSGRNRVVAAEPEDAVNGVSNEAGHLL
>A0A4Y8E6J1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTKFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGSLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
ENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAHDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A376P2Z7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCAYIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A6G4PBG5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMICIVHDIT
EQKLLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376RIX7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFL
LQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSV
LIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEASENE
TLRTAETYSQSGGENQTESRKRRGYCPLTFHRCRHV
>A0A1V5QTI9|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MAKLKNPSEIARETLKQLAGRRMLPTPSNYRTLYQEISGTQEEEAFPEKHLSSLAAAIPK
ATPEQLRLARELEAAVKASSWESYRAHLIDFISNIATSQKLAWAELINELLKQWEAKHSG
ITPARKREALDRVLGNTSAAPEVLYNRLQNIVRNWAQGREADMALEGAMPASGATTISTE
ATSETPQATATASAHTTNRDGELLRELRELFAYTLETAFAGQLAETPQLASDAKALADEI
RKASNQKELEEFLTHLKRFAFRLELLSEDQAELRKSLLDLLRLLVENMSELVLDDQWLHG
QIEVVRNIIDKPLSQHAIDDAERRLKEVLFKQSQLKQSLHEAREAIKSMLAGFVDHLADF
ADATSGYHDKIEASAEKISVAKDINELETVLAEVMRETRNIQINAQRSRDELRATQQQVA
EKEARIHELEHELEQTSTLVRHDQLTGALNRRGLDDMFEKEKARSERHQTTLCVALLDLD
NFKKLNDSLGHEAGDQALIHLANVCRETLRPQDTIARYGGEEFIIILPETGLDAAAAALT
RLQRELTKRIFLHEHEKVLITFSAGVTELRPEDSQATVVKRADEAMYKAKQSGKNRVEKG
>A0A7D7DS07|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDSHSYGLCQFGRWIDH
LGPLDNDELPYVRLIDSVHQHMHNCGRELMLAIVENRWQDAHFEEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRALATYLAGWTRDYDTVYRYGGEEFIIIIKAQNDDEACRAGLRICQLVDNHAIAH
PGGHIPITVTAGVSRAFPDEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQSVIARV
>A0A1C3RJP0|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MNQSIQRIFVTLGFITLSVIIISFVVNDFLNYRHKIAETVRLNGALIEKATDQYFITYKK
IFSALREHRCVLTKETDACSNLFNRLNETYPFIENFAAVDKSGLFFASGQKFNREKPPSI
SHLPFFQLLKQGQLHYVMDPHIGPISKEHVTGLVIPILKEGRFDGLLGASIRTQEIQQVW
REVTIASWNGVGIVNRKGDVIFQSSESLQGQLLEIAKFLQGEDITKGPSRSFVTNRGASL
ELYGLESAVSGWKVISFYSRDDLLSGYLEENSWVLVVLIPALALLITSLLLFSKYQEAAS
SRMHLVSQLQYSEQRFRDFANAASDWFWETDNEHILSFTSAVEEGSERNLSLPEETVGKS
LKDLAWKIEKDDDKESFGNVIRKREPFRNIEFKVEDKNGKTHYWTASGGPMFDSNQKFQG
YRGIADDITKAKDAQKKIEFLANHDALTGLPSLRLGMDRLQHDIALAKRNKTFVCVLFID
LDGFKAVNDTLGHKAGDQVLKEIAGRLNQCVRETDTVARIGGDEFLVILPNLNAPENAYD
VAQAIVEQAAREIHHGEKTAQVGASVGIAVYPDDGVDPEELIHNADEAMYKVKHSGKSNF
SMASNS
>A0A660GLK5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEELPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A3P5DQE9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGAGCPADARRRSSQGIFDMGTVRIHRRSGTGAAGIVI
>A0A1S7LJ00|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MIMIEFGGDGMNEQSPEQRDSIQEVLARINEDLSCFIRQELEVHDGEQTVQKDFGEMRWD
AAFGVVQPINCWEAHQCGKSDCPAHGNITERCWLVAGTLCNGRVQGELASKFKSCQSCNI
YKEAHDQPVRSLLENIHVLVVHLQGKARKLHELSIRDGLTGLYNRRFFDEVINHQIVSAR
RQSMGLALLAVDVDKFKTLNDQFGHQAGDQVLVDIAQLLQDATRSSDLIFRMGGDEFLIL
LTQLADRSLNEVLSRIEGAVERWNSVDHGMEWKMGLSLGPAPVDSDDIEHALARADEAMY
AHKAKKRVGRVG
>A0A7U9B3F6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA143|TrEMBL
MENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5E4T0T4|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MKTTISRTEPGNRVAATTILVACAALTLAGFFARAIQGEVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTHAPFWLWLMAEA
SFAAYVMLSVRSYTRTRSDPHIRPGYKEAAWYGATVLVIWATVSLALIGTGRPLIIAPPV
GGIGVETLALYALFIAYVALWWRVATVTRLSHKLFLLVWVVVTISLCQLLLSLTAPNDAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFVDPLTHIYNRRYFDNR
IRLVADRVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDTVLQRIAGTIQHCIRLPSDFAV
RLGGEEFAVVLPEIDQQAALRVADRIRESVKRASTELLPEKARDRGEAITISVGIATWQP
GAPLVISAMLERADRALYQAKHKGRDQSVLGQLAA
>A0A1R3TTX2|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MFMPFLFKADSHCDNLRKGSRVPDFFTLYLVVLLLNLSHCLIWGLIAYRYRDMRAARYWL
AGSGASAVGGIALSLQGENGLLLNTVAGNGFIILGFYLNWFGARRLHGEKVEWIHVSYLL
GGSVLVMLATFHLWYGRNPVYTLAQSLPLTLTALYLMRPSRRDLGAVIASTAMVMGGLSH
CIIAGGNMLIVTGLRPDLQIYQSASIDLLVFLFAAVVWNFGFLICTVDRLQTEIERLANE
DELTGVGNRRMFMNRLNEICRKREGVNFSLLLFDLDRFKVINDKYGHAAGDAALKHATAV
ITKQLRPGDAFARLGGDEFSLLLSATTAAEATAIAERILSAVKGTTFSWGTLQLGLAVSI
GIASSKGSLVTPETLLENADRALYEAKRRGRDGYSLFGSHLKPASNIVRLGDFVPSGSAA
RT
>A0A2J7YJG0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MVFPAQSRVLPYVVVLGVTFALTLGGILARPIESLSLFWPVNAVLAGVLLRYPRQATFTG
FCLVWLAMVGADLLCGSAWGPALWFNLCNLGVVVTLWQLMSRLPRMHRRMRSPRGVLSVF
AACAAAAMVAASMAAVKAAPWFEQSLRATWLAWFSEQFSTGVLVLPVLLTAPSVRALVRG
GAQPIRLAPLLVLLASLAFSIAFGGPGAIAFPIAALLWCAWTYSPFLVSLLTLTAGSTLI
VAVAQNLMHFSVPQSEPGVTTLMSARLGIAMLVLGPLVVACVSQANRSLMARLAHQATVD
HLTGVLTRSAFTRRANTLLESRQQHAQALPLTLMMLDIDHFKSINDAHGHAVGDQVLRQF
ASTLQDQLQNDELIARLGGEEFVVILPGLAPERANFIAERLRRAIQDLHVVQADQRLQIT
VSIGVAGCDADMPAPSLDELLASADQALYRAKARGRNRVEQAEAQRLVI
>A0A088T0X7|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR1|TrEMBL
MNFVLRFDLNIFAIVLLVALLLVVLFKQELITLKGKIFRWIIIVTIIMLALEIFSWVFDG
VETRNAYILNFTFNFFFTALNTVVVCLWASYIDYIVYENKERLRRRWYYFQPFIIVFILS
IVNIFTPVLFEISDQNVYSRLPFIWISITMTFILYIYALYIVIRNRRYLNSNVLYGVLIF
LLLPMIATLFQLWFYGLLVIWPATAVALIFSYLIFETTSSSRDFLTGAYTRMRAEEFIKT
LLKRRRKFAVVMIDLDDFKVINDTFGHHVGDDMLIEMTKILKSVFVNKAVVSRYGGDEFL
VVVEGSSDGDMQLYRRKIEQALINSESVYAQAQKFSYGVAFCENFESWTMESIITTADNN
MYLDKAKNKNHKRRRSDR
>A0A1R3TVY0|diguanylate cyclase|EC 2.7.7.65|Agrobacterium sp. DSM 25558|TrEMBL
MQSEKRQIMPTLRRSLIAKIFLVSFLSVHVPLIALIIHLLSGFDTGPVPVFSLILGATLI
GTAICLFAIWRFIRPLHHLAEALMKYPQDKSVLKLPSGGADEIAIVTDAAKSMLWQVEEL
TKKLKHQATTDFLTGLGNRRWLTEQLPAAQSQAERANEPLSLVLFDLDRFKQINDDYGHD
VGDNVLMIVGEIVKDSLRPYDLASRIGGEEFCILLPRTSGEDAINIAERLRVAFETSYLD
PLPKGRITCSFGVVQAATDERLQQLLRRADTALYRAKDAGRNTVIGVFADKSI
>F5RKM6|diguanylate cyclase|EC 2.7.7.65|Centipeda periodontii DSM 2778|TrEMBL
MVNRRWCIFVQAIFFVWMLCTCHTVFAETSELSWEYWQPNRPDADEKAAKSVPAFPKEEG
RWRKFNPQFGVAVPEGTHYVWIRVYIPPDTGVDESLFFSTTDQAVQIFIDGVSIYRYGDL
NLHDFSYGRKWHLVDLPAWAVGRHIYIQAHSDNIWVLGQFDRIRLDRAAHQIEVVFLYDF
PYVSGITALLIFIMLLGVYFFTEKKLRDIYLRLIVVLVIFFVWMISSSSLMLLWLDWPVF
WWNLELISTYLVPLSANLLIYSVIDERYKKNILQVSCIYGLILFLAVLFELLGQNGLYLM
RFFYYPALLVCGLMIAYWLWSCHERGNQRCRPLLIAFGTLSALAVIDGMALQYRLFAWHM
YLVPFGIYTIGFFIVRLILERAAHERYLTELSASLENEVSVVTKRMEVDPLTGVFNRNKF
LAATRDFMRISIETKEPFALIMFDIDHFKKINDTYGHDVGDVVLVGFAQTISGFLDRRHI
LIRWGGEEFILLCLHYDGTEAEAFANIIREAVSRAHIHPSEQVTCSGGVAIWYGTDEDTA
DHVVKRADMALYQSKESGRNRITCEPDWRAHMPSRRAKGKPVAKPHEINYPEDSLKGIWD
R
>A0A120D6P6|diguanylate cyclase|EC 2.7.7.65|Candidatus Magnetominusculus xianensis|TrEMBL
MTNQMRTGLYLAIDELRKQDNSIHMIHQIICNLVNSVGITSAVFVEKNQKDDYLKIKYGY
NVSEQLSQSYKRSIGTDIIGRIFYQDEFAIVINGENESNYKDIFLEHDYDMAVLLRMSVE
NRAMGFLALYFDKRLEITDELKSFLIAIASICSEAIRKEMLDNLMKDTRTIDPQTGLFYY
LYFHQKLKEEVNKSRKTDSPLTVAIIDMDNFKEVMNAHGLETAHNLYKELADELRTHLRS
IDIIGRHGTDELIICMPNTSCGSACLSMNSFIEAVRDKKFTSHQLLTSIAIGTATMHKNE
SLEELLHRAQLALYKAMLMGNKIAICYET
>A0A2T0AWK0|diguanylate cyclase|EC 2.7.7.65|Moorella humiferrea|TrEMBL
MSLKTKVLLVFCAVFALLALIFFAVSHVIAGNIAGKLENESIRENVERALQALEREIAAL
DKSAADWATWDDTYSFVEDRNREYIEKNLVDNVFQILRLNYAVFLNTRGEIVYARGYDPE
AGEEIPLPPGIVFTAHNQTGGLKGVVVTPQGPVLVAARPVLKSDGSGPARGTLIFARTFK
DKDVKELSEITRLPLSLHPPEAIDFRELKPAGTLKNGEPFYVKIVSPEESAGFAVIKDLQ
GESALILQANSYRRAAQAFLSARQAFSLFLALAAALCCLLALFWVDRAVLSRLARLTAVV
TGIGRSPSPAPGIPPLEGKDELALLSSEISKMLERLEEYQRELGEKEKKCSSLVDNATET
IIVVQDGVVTFVNRATLAHTGYTAGELLSRPFLDFIHPEDRESAVQHYRELLEKKSPLYA
CSFRIFAKDGSVKWMEANSVVIEWEGQPATLHFLTDITPRKILEEELQRLMAEKSLILDS
LTEMVAFLDRDMHVIWANRTAGQSVGKNPEELFGAKCHEIWQGKSAPCPRCPVVQAMETG
QVCTGEVASQDGRFWSITATPVKDKDGKVIGAVEATLDITERKRYEEQLRFLSLHDSLTG
LYNRAFFQEELKRLSGSREYPITILVADLDGLKLVNDTLGHAKGDELLQACAGVLKTSLR
RSDIVARIGGDEFAAILPKTGEKTGEDLAQRIRSAIEASNKEHPELPLHFSLGVATCQNA
AESLEETFKKADDLMYRNKLQNRASARNQIVGALLAALKEKDYITAGHAARLQEMCLNIE
LGG
>A0A6Y6LZB0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Typhi str. CT18|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLTLETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQQFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTENTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISIALT
LLWGLFTAMLLISWGVIRHMVKNMFVLQNSPQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEELCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A737LIC8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:f,g,t:--|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5B8RLZ4|diguanylate cyclase|EC 2.7.7.65|uncultured organism|TrEMBL
MVLFDIDWFKSVNDRFGHPVGDRTLIELTHRVAAILREADQFGRWGGEEFLVLAAHTDLR
GATVLAERIRRAVADAPFPGVGPVSVSLGVAEMRFGWTLAMLTERADAALYEAKATGRDR
VVVAPA
>A0A8F7M4I8|diguanylate cyclase|EC 2.7.7.65|Aeromonas sanarellii|TrEMBL
MKRKIMIVEDSLTVRRMLTQAIAQQTGLEIDAFDTLEGARDCHGEEYVVALVDLTLPDAP
GGEAVNVLLARGLPVVILTADISEEKREAWLEAGVLDYVMKDSRHSLQYAVSLVHRLYLN
QAIEVLVVDDSLTSRHRTAAQLRKQLLQVHEANCARDALALLEQQPAIRLMLVDYYMPEI
DGISLVRMLRERYNKQQLAIIGISVSDKHGLSARYLKQGANDFLNQPFEPEELQCRVSHN
LEALEQFTSIQESANRDYLTGLYNRRYWFNEGQKWFEEHQRQQAPLALCVLDVDHFKQVN
DHWGHAIGDQLLCHLTRLLTQFFPDAMIARFGGEEFALMVPHCSVPVLLKRLEGLRQQMR
QQPLSRETPLFVRASFGVINVGRLSMDEALCEADRQLYQAKNTGRDKIVAQNA
>A0A5P9FH43|diguanylate cyclase|EC 2.7.7.65|Roseivivax sp. THAF30|TrEMBL
MTDTNSSVERAAALLSLEAVFAHAPRAIAVFTLCGSLVYTNRLGRRAFLVTGQAGQHRSR
LSEDPTFVADLRRISSASIACALQIRTPAGRLEAIGWRMHDVPGLPAGLIILKQDTEQSM
SARLLAASESRAQASRELAVIEAEREHLQAQARRLSYLAATDRLTGLLNSEEFARRCRTY
LHAPRKRAGTFVFLDCDDFKSINDTYGHRTGDIILATLGARLRSFGRTDDLVGRLGGDEF
GIWFAGSGAREAARLMDRLRNIVEAPIPRPETSGLVGPREISITFSMGAASAPVDGARYS
DLLETADARMYEMKTTRRLRA
>A0A6L6HAS6|diguanylate cyclase|EC 2.7.7.65|Erwinia sp. CPCC 100877|TrEMBL
MLADRIQRKSFFKNPRRVVNICFIFVFICSTLLTWREMAVLEDAWISNQRNSLDNVATAL
DRQLQHSLDNLLFYRNIMSYALRYPISTDKTRQAMADFERQRTRQHWQIKLDVNRSMPLN
GVSDKFVDTSGLLVRDADYLHGELSAALEFSYILQLSDNRRDLQHRTYYLSRAGFYISSR
PPQNDEQLVARYYRQVARPWFSRHSERYNRGRGLIWEHAREPGQESEQVITASVPLDYEQ
RWYGVLAMDFTIDSMRQFLLRALQEKNDGLVLLYDRKFNAIATSADAIPEGKLFTPTQMA
QLASAMENKNEGEIRMAHRVVTWDKLNNFDGVLVKLHSLDEGIRGEFGRISVVLGLLWTL
FSLMLGGSWLLIHRLVKNMMNLQSTLSWRANYDTLTRLFNRGAFFEQAQHLANHCRQIGQ
PFAVIQLDLDRFKCINDRFGHDSGDRVLASAGAILSASLRGGDIAGRIGGEEFCIVLPGS
MLSQARAVAERIRERINSKEILVRSGQTLRISASFGVSASQEHGDYDFEHLQSVADGRLY
KAKEGGRNRVCDKD
>A0A377HR78|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MSKEIFALSSGYLKKVVPLLMKYQVPATPPNYALWYTYVANADTELSQKIDASIRETGTL
STTRCEELYSAHVADEKVKELDEFQQGLQALALEMGSTMEDTLKDTDTFQSTLDKTFSQL
ARVDEEALSMEETVAVVRKAMKDSNALRQSTDFFKNQLAEAQKEIVRLEDTLHKANEEAL
HDALTGIYNRRALDAELEALVATPPPKGFSLLLCDLDHFKRFNDTYGHLMGDQVLKLTAK
RLSDYCRDGIKAYRYGGEEFALLVPNRPLSGACRVAETIRATIDKLALKDKRTGKKLDNI
SISIGVAAFEHGESIRDLISRADTQLYDAKKLGRNRVMPVT
>A0A0F3PUY4|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum str. ApWI1|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLIKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNLLQESF
QETTILSDPTQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSILLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMHFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>A0A809HH27|diguanylate cyclase|EC 2.7.7.65|Serratia sp. P2ACOL2|TrEMBL
MDISAPNHLITRQGALLTHSLLAAMAVFLLALLCLTLSNESSHFTPLWFPTAAIIAVLFR
HSPRQWGLPLLACGVGIVAASVTLFGFSWFPVKLTLINLLEAVVCTLLLRRMLLQDDPLN
SLASWLKFVVCAVIFTPLFSALLAAWWVPAPGHPFWHPFSTWFISEAIGVLSLTPIGLVY
RRRMLDTLNLYTLLLTLIVALTFSYLALSYLPFPFTFVILPLLWAAIALPRLEAFVICFC
TTLMITVMISIGLLHFHAPTGPFSDIEIYLPILLILIPAHSMAMVMHAFRVEKQHIVESE
TRFRNALEYSAIGMALVSPQGKWLQVNQALCKLLDYTPEALRRLTFQEITHPDDLNADLT
QLHDLLDGHISSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKRTA
AENHRLMERITLANKVGGIGVWEWMMHGEELTWDKRMFELYDLSPDQTPTFSLWRTLLVP
EDRERTDREMATLLKRPGPFVLEFRLLTREGKVRHIRGQGNVILDAQGLPLRMIGTNIDM
TEVRNLTEALHEEKERLHITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPV
AGVVRMTNGKDGEEVENPIQCCLQENRQLSADYALVLHGRDGRCFDIQQSVSPLKTIDGN
VMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALV
FLDLDRFKAVNDNAGHAAGDALLKDLSLLMRHHLRNSDCLARLGGDEFGLILFDCTREQA
QSLIQQLVNHISQHPFFWEGKIYHVGASAGVTRIDADAGKSSELLAQADIACYTAKHRGR
GQVYLYEARQKMILERQHELLTRQEVTDIINDGQLLLHVRAVAPPKTPLAVCFYQLKLQV
RDQDGQALASDDFISAARLYDLTQEVDRWIIGQILTQRAPDIARKGLSIALPLTTDSLLD
ASFQDDLLAALDASPLQPGALLLAVDDAVVLEHAGICRPFLHQLQQRGCKLIVNGFGHSL
NAFDELHGQKIDYIRVDERFITNVHCNQMDELMVSMLNGATHRVHAQTLAGPAHQQITLN
TLQAIGIDLSDGDAIALEQSLTELLSGGYFGIR
>A0A174EWU2|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MSGKKRNVMLFVLLFTLLLGVIVPVQAQSYGGTKIIRVAYREDADFINKSSSGVYKGYGV
EYLNKISQYTGWRYEYINESWENQLADLKSGKVDLICNAQKTEAREKDYDFSCMPVGTEQ
AVLYTSEDNGDIYFQDYEHMNGKKVGLLRDSYQNEEFEQRQDEKNFHCPEEYYESEQDQI
EALEQKKVDMILTGSISKHDSLKIVDKFGAAPMYIMTTKGNTEVISAVNNALEQLKAEVP
DLTENLTEQYVMDKNRNSRPLLTREETEYIKNVSAPIKIGCIGDQPPLIYTDKETGKLDG
IYIALLKKFSEISGIPFEFESLSPDTDPIEAAQSGKYDFVAGITACQEMIDEPEVHLTGG
FFTREFQIVAERGEDINTLETSTVSMNSIFEKYKSLRPEGEFPYKAIYCDSPRTVLDAVV
NKKADMAIMDSYAASYYLQDEKYRDLALSGIVFTKAETCMIYGDNTDPDLVSVINKSIGS
LSSQDEENIIRQYSINLLKSFSIWEFMEKYRYQIVCILIFLVALTILVIVNNRHRTQMQV
EAAAQEAYRCRMETDELTGLLNKEGFYQRGREFLEKHSEADARIVYINIENFKLVNDLFG
EDAGDGFLKFIGLELEKIFGRIDIVSSRYEADHFVILTLDNEDRIQAKINHFCNRIRDYY
LKTTVEISAGIYEIRDRSKSLRIMCDRAHLAADSIKKNHMIQVAVYDDTHRKKLIQEQMI
INELDDALKEKQFNIIYSKNSPSSIGGR
>A0A1F2PIC6|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNITVLNIAVILIILFLFGLGLYFILKRGRKRKKEREIRRFNELVQTFIESEEIPVSLKD
DQLNYIFINLAMEDFYGINSEDIIGQDDFEILEEKMAIKERETDKKVLATKTFVTDEMLW
KGKIFKTTKFPVDLLNGKFGVGAYIRSASEKNREKYLKTLMSISDGVMIVDPLGKIEMLN
NTAEEMTGWPVREALGKHYSLVFVLEDEKQADLVPDHIAEAFRDNAMKEFDTHVLLVSRD
GRKYHLEDSVAPISDEEGHIDGAIVIFRDVTEKKEKRAAIEYNSFHDALTGLYNRRFFEE
ELIRLNTERNLPLSVIIGDVDGLKLTNDIFGHDAGDELIKKVSEIFKKVCRADDIIARWG
GDEFAILLPQTEKKDAQRLSDRIKDNFSKEKIKSIQGNVSLGVATKYEPEENIEVIIASA
EDNMYMKKTINRGKKKEDTFNNILDKLYGELPAEAEHARRTSEICKKIARKMNLSEAEIN
KVSKAAYLHDIGKVALDKEIARKNEYVIDDTYKEMKMHPVVGFRILNAFDHTVDLANIVL
GHHERWDGSGYPQGLMGQEIPKLARIIAVGERFDDMTAETDYRPAISIDDALEEMKRNVG
THYDPDVVAALEQVIRDEQTYTRKITR
>A0A1F2PFE2|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MTNDFYHGIIKNLHVGYAYHRIICDTQGTPVDYEFIEVNRAFEAATGLIGAEIIGKTVTA
VIPEIRDSGFDWIRFYGEIALNHTTAEIEQYSSPLNRWYRVQVYSPETNYFITLFNDITR
EKRDLAERNLLLTTLHDIVFEISTDYHFTNVIVQDETTLFVPKKNIIGSHITSIFSKDLS
EEIIVVFKAAHDTGQKQEFEYKSPVPTDKRWFLAEIFYINDNESPRFVVSIHDISRRKRM
EKSLFIEKERLQTTLLSIGDGVISTDSRGCVTLLNKVAENLTGWNQQEAYGLPLDQVLKL
VNEYTRESCENPARRVLEEGLIIELNNHTLLLSKDGREIPIEDSAAPIKDQDGQITGVVI
VFRDFTDKKEKQEKIEYLSFHDHLTGLYNRRYFDEELKRLNTPRNLPLSLLIFDVNGLKL
TNDAFGHMAGDRLLKKVAQTMQTISRSDDIIARIGGDEFVILLPQTEIQEAKELAKRINT
ALSHEHLEAGQISISSGWAVKTTADEEITEVFKAAENKMYQYKISERNSTRNEAIQFIMK
TLYEKLPREQQHSERVSNISGLIGAAMGMNKEEINELKTAGALHDIGKIAIGNEILDKTG
ELSDFEWLEIRRHPEISFSILSSLNDYAPLANIILVHHERYDGTGYPKGLSAEQIPLPAR
IIAIADAFDAMTYGRPYKEPLTTEAAIREIVAGKSTQFDPAIADIFLSVLAENNYCL
>A0A1F2PGR8|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MHLNKNWYTHIITYLWIAIGVSSSVTLLNLFFSSLAPQSFFLERFLFPLLLEVIILIVLK
KLIRLNTTVTPYFIIVGCQAIVMILFMVHYPVFYVMLSLFLMPVLISIFFLDLKLIDFSF
YLSLAVFVGMKLLFPPLSMMSVIEVTTFSAILVSSYFLSRELTKRFSVVYTDMVISVEKE
KELLYRNIYMEKLTKMDLATNLYNHKTFHEYLDELVAQCRKQPFNLSLGLMDLDRFKGIN
DRQGHGNGDKVIATAAAIIRDNLEANDFAARYGGEEFAVIFTEKSPEACLEILERIRTDL
ETAVFDTMPDEVVTMSIGFTPFTPKMSKTDLFEAADASLYSAKKNGRNQIQCAS
>A0A8G0X2R6|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MGTQFARTFARLRQRTRSTVAKVLLIISMFVGICIALVALVYIQGNIFDGVRTYVRGEGL
WAKAQKDAVLYLNHYSHTQNDVDFQRYRAATSVMEGDHRARQALLATPIDEQAAKQGFIQ
GLNDERDTDSMIWFFRHFQSNHYMQQAIQLWGLADQRFEFVVQLAENMRIEINQLGARPE
VLAQYRQQLIDANEELLSLEIEFSAVLSEGARWVKQMTWLISLGALLLFISIGIFASRQI
IRNIARSERLLQISESRFTSLKNSDTIGIISWQLDGTIHDANDHFLQMLNFDRADLTSGL
INWRSITPPEYETRDAIAITELEQFGRCQQYEKQLISKNGVLVPVMLAASFLNGSKHEGV
AYFMDLTASKQAEDKLRLAATVFNASTDGIMITDPLLSIISINQAFTHVTGFTKQDLHGD
ANDFLNDGHNNDDARQAMRNLLQQGEQWQGELLKTVKSGDLLPLSVRINTVRNEHDRLTH
FVIVITDIAERKAEEEYLRHIAHHDALTNLPNRVLFHTKLEQAIVHAQRTQSIFAVLFLD
LDNFKPVNDSFGHDVGDKLLQEVAMRLRSSTRQMDTTTRLGGDEFVILLERLANTHNIAQ
LVPKITQAICAPYTINGHQIHIGVSVGLALYPENGTDAKSLINHADQAMYSMKKINKIQR
QNSV
>A0A1F2Q9H1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MDRSTRRVRSCLIFVAILVVALAGIAARPPGFLSTFWPANAILLGILLRNPRSFAPIGLA
VGGAALLTADLATGSPVQRAFELNAINLVGVTTGLIAANLLGCFPRRISETKYTTRIFVV
SVLASFTAGSASALRTQLHEGSGAGTELVGWFFADLCTYLIVLPILLSAPPFDHVRRTFG
PSVRQNLRLRRVAQILLPLAALLACLPLALEVQGALALLLPMPALLWCAMRVSLFSTSLL
AAGWSAWALIMAGQGRLALADPVHLLSEGVTTRISVILMALSPIAVAVATGAQRRAEREL
QRIAECDALTGTLSRHAFWTQSQELLDTQHTARKSIAVMMLDLDHFKSINDNLGHLTGDS
VLEQFGNTLLATTEGVGLSGRLGGEEFAVAAADCTFEEAIALAERIRQRQEAHSRSIRGF
AGTVSIGVAWVDQAMAEMDALLDIADTAMYQAKREGRNLVVAVDLYMAR
>A0A1F2PTI0|diguanylate cyclase|EC 2.7.7.65|Rhodococcus erythropolis|TrEMBL
MVSTVEKSLSSSAVRRALLIGVVVFVSCLVGILSRLPGTLAVFWPANALLLGILFRSPRS
ATPLTWICAAAGYVGADLITGGAWESTVWLNAANIVGVASGFYAFRWVGGDDRRLTSIQS
VGYLVSMTVVAASMAALVGGIANRVLFGGQWWDGWLLWFSSEFVNYMTIVPLVLTFPSLR
RVDRDPKAVATLLRRSVVPTALLAICIILEWVIGGAGAIAFAMPALVTAALLTNVFVTSV
LTAASTAWTLVLTADGHLGLSSEGVSPVSASVQIGLSLLAVAPIAVACVILERRRALEAL
TQAVTHDDLTGALRRDEFLRRGGSVTGAPDPRRHSGRPVSVLMMDLDHFKMVNDNLGHRA
GDTALVSFADQVRRNLDDKHLFARLGGEEFVVLMAGVDLEGATETAEMIRRAQAENSSAV
LGELGPTVSIGVACSPHGDADLTQLVDCADEALYRAKKLDRNRTVALTVGS
>A0A0J6C7M7|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MVHSPSRFRLRSLILWCSLFFLFAALAASFYATYRVKRDVLIQDTLQANRVYAEKLASVT
ENYLRSCRRLLFVSADELRGQPTLDRDAMQAMVDRLVQLSDLFNSIIVVDAKGVVLADSS
HTEGLVGQRLIHPFAKLAMAAQGPLTSQPYRSPYSGRWLVSLSQPIFGADGQATGYIAGN
IYLHAPSIVRGILGEHSHEDGSFSYVLDSSGMLIYHPVSTREGESVHNPAEQAVRRGEHG
SMRFLNQEGVDMLGGYAPVASVGWGVIVQKPTKAALARVDRALALTLLYALPAIMLAIAG
IIWLSNLIARPLRQLAAVASRMEERDVSDHLRAIRGWYQEAAELRRGLLLGVSAIGLRMG
RLRKESSSDPLTGTLNRRGLAVALEGLKAQGAPVAVIAFDIDYFKRVNDEHGHHIGDLAI
TQVSHMMEDLVRSGDVVARLGGDEFLVLLPQTSLAGAAAFAERLRQTVAQARVEECGPIT
LSIGVARYPDHGSNLDAVIKGADKALYDAKEMGRDRVRVMTAQGMRDARDIIAGAK
>A0A1C5U6N7|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MLKELCGRFYSLLKKEAAHENEPQRILFLLRNIMLLLGLYFLIFPLVMCLVSPRTRGWIG
YVFAVLAALIFFGTYRLRVRTGVVMCVTLQLAWVVIFILMYGWDCGIQHLMFEMLVLVYF
AIYNGVGYKIGYTAFLFAVRFVLFVYCRRNQPYYGLTENATVVLQIMNMILSFVLMGVVC
AMFSSNVESAEKKLVLYNEQLKKQAGTDPLTGLWNRRQMMQYITEKHQKDSNMAFTLGMG
DIDFFKKINDNWGHDCGDAVLVWITRHMSEVLGEHARLCRWGGEEFIFFFPDMNGDQVCE
ILNVLRMRLDNDPFDWKGEWLKVTMTFGVEENDFSSSIDTLLKNVDDKLYMGKKQGRDRV
IY
>A0A1C5UJZ5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MLDEKVLQVAILIWGCVFCAIAAICIFLSSNYDREKRRYLILMESFASMLLLMDAMAHIF
SGYPGVPGSVMVRISSFLVFLLSDVVLLCFHIYVCVYLFSKRERRTLKRVKAGYVIAAAG
AVFVVISQFTHWYYYIDVDNYYHRAPLYIMSILLPAAGLLIDLTLLLQYKKRVSRKLLFS
MLSCIVLPAVAAAVQAFRYGMSLIDFSVGISMIIMFIVTMTELNQEMYELISREGKIKER
LEIATILNKCIAELISGEDEDAAISNLLRIISGYFDGDRSYIVQIDEKRNVCTNTYEYAM
NGVTAEKDNLQEVPMEMLDIWMDSFRKNGLYYIPDIEEEQGQPYYETLKMQDITRLLAVP
LNSDGKIIGFLGVDNPRLHYEDHTLLSSIQYFLTDSLKAKERKARLQYMSYRDMLTTLYN
RNKYIQVLEGMQAKTVIKTGVAYIDINGLKRVNDLYGHEAGDRLIINTARSMLAILPENA
YRVGGDEFVLICFDIDEKIFRSKVRDICDSIAAKRISVSVGVVWEESSSELETMLRRADD
LMYAEKKKYYEKHGTM
>A0A1V5BQE5|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin065|TrEMBL
MRPRSIVHILYVWLVVGLAAWQLYLLFPALDLDRVRELLSIVLLGVLSEWLAVSFPHGQL
SGGFALVLSAYLIFGPAATAWVSGLSTLFGQGIANRGNPVRTTVFNAGQYVLAAVAAGHI
YQFSGGRLGLSGFAEILPLAAFTVCYMGINHLLIYFYLLPKRRYYPGPAWLDAAKWDSLT
YLFTVPLGLLIAMIYIYTGLTGIMLLFSSVLALQLIMRHYIHLHVANRELKAFYDVATIL
EKNPEPAELLAFILRRAGKVFPYHSGVAYLRSGERDSFAPVAATGPYSKHLSQTKVYSGE
GIAGCSIADRKPEIISDCRTDSRTRNEAGLCQIMRSLLIIPLLSGEEELGVIVLGDRRPM
VFDEKHLHIMAVLGGQAALTVGKSVLAGRLEHAASLDVLTGLLNSGVLFHAASEICGTAG
GSGVAAGLMIIGVDRFKAFNDRYGRAAGDWTLAELAGIIKGATRGDDLAARYGGDEFAVI
LPGASGRRLMDIAGGIRDEIEEHYFLREAGKQARITVSIGAAEFPQDAGDAAGLFKAAQR
ALDKAKKDGGNRVVSAAVSIIGLPRK
>A0A0D8HJP2|diguanylate cyclase|EC 2.7.7.65|Acidithrix ferrooxidans|TrEMBL
MPKQSEPGKFASAIEKTQLNHWLKDAPTSLPLTTGSRGKWISALVIAGSFMGIVITYALG
SPAFFLIDYILNGAFMIVGFAVYAMAERIGRVGINLVVIASTSVITLEIATGYGKDPSIL
AVVFYVWVALYVFSFLSTAESLGHVGYIIVAYTIAIVYGDKPSAPLADWLLTVSTVIVAS
TSSGYLNYTIRQIAITDSMTSLSNRKGWDLAAPRELNRARRNGAFVVLAMIDMDGFKEIN
DTHGHPMGDQILIDAAKAIRASVRPFDIVARWGGDEFIFLSLVATRDDANAFIDRVVTNI
QSVSPISCGAVVASPDREIQEMIDAADAALYRSKRNLETSYQLLDI
>A0A376DD00|diguanylate cyclase|EC 2.7.7.65|Edwardsiella hoshinae|TrEMBL
MMDLFGDERQRAMALYGDPVQPRRRFTRRRAWFLALLGILMAVITVLHFAYLPHYALPRF
NGFAFVLELVDYLTVLLMLVAVQYSALDRPAYLCLTFGLSLWLLSGLLNLLDEIVVQPVL
LGDLEDVLHSLGMLIGAWGGGYTLRYLARVRGRLRYLAMFDDLTTLPNRRHFYSYLMSRT
QPRQIGLLIIDLDHFKRVNDEFGHSVGDRVLFQFGRLLRAEFSHHAFPARIGGEEFALVL
EQTDRTRLLESAQRLLQRASLIRIAEERMLSVSIGVGISRPGEMLEPFIHRVDDALYQAK
RAGRGTYRWSPDATPYAH
>A0A1J5JHH7|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MLTVKSLISEKLYTIDPLASVGRAAAIMERYGIGSLPVVDEGKLVGIITSRDVRRFHPNR
LVADAMTRKVITISPTASLTEAQKLMVKNKIERLVVTSESSIVGIITYAQIMLELGKYTD
SLTGLNKAEIFYEKALELLRRGQEIAIIFLDLDNFGGINKEYGHIYGDNVLRQATIILKN
LINMNEDTLCRYAGDEFAIVTTRSLAAAEKLARQIVTAFANENWPGKIKVTISAGVAGGR
RSKIRECGKDSSYIVKNLVNMASLASTKAKRLKKPVVVVEAVEFKETACM
>A0A094KW18|diguanylate cyclase|EC 2.7.7.65|Candidatus Izimaplasma sp. HR2|TrEMBL
MSINSGFQLNIYTIIILFILLVSMFTKRETYKVSTRMLRLIMLTVITLLIIEIFSWMFDG
IDKEYAYTLNYIFNTIFFVVGVAAAGLFTSYIDYMNFRSKSRLKKRFYYMHMAILALILA
TINFFTPIIFSISAENVYSREPLIAVGFISVYLLLVFMLVQTFRNRKKLDDNQSLSMYVF
ILLPFIGGVLQLFFYGLLIMWAFSGLGVLIAYIFNETTSNSRDYLTKLFTREITYSYMDS
MIEKNQSFIIISIDIDDFKNINDSFGHKVGDEVLFHFSKILSLTFGKNALVSRFGGDEFI
IVIKDGSEEEVIAYHNLFKSNITLYKGYRFIEKINFSFGSSFREIDSIESIDDLLEVADD
LMYDEKAQHKNKKRRLTDK
>A7ZN78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H28 (strain E24377A / ETEC)|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNSGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNLVCASDNA
>M5CWS6|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas maltophilia RA8|TrEMBL
MIKPDKPANEALRLEALYRYRILDSQREKSFDDLVAIAKAVCGTSMAAVTLIDVERQWFK
SIQGIDAAENLRSDSMCGHAILQPQEIMVVEDALQDVRFHDNPVVTGDPHIRFYAGAPLI
SSDGLPLGTLCVFDAHPQHLPSDKAEALAALSRQVMLVMELRRFALDIQKHMLERDDYER
LLSEYQDVLLAQNADLAEQSRTDALTGLPNRRAMAAALEEAVAVVDDQPGVACVALLDID
HFKHINDFQGHATGDRVLAELGVLLRSHFAGRGMAARYGGEEFVAVMPSTDLHTAELQCE
FLRLAVADLPLGFPVTVSIGVAQHQPGESVDDTLARADKALYRAKGNGRNRVERAG
>A0A1S8Q6X0|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MNKLYFLKKLDLNLTEDQKATVINDINVTNLERMKLILIIFIIVEILFILFNDIPYLINH
SSNVIWNDSKYFILHSLNVIVSFVGIILIKLLTKYSKNKFRLMNKLLIPTLTILILSSMA
MINALDQAKPGNVSSVFIANLIIFSSIIMLRAPLNLAVYSIPFLAYLGGLVIFQNDINLL
VTNIINGLIFFLAIIIISTGIYNSNYEKIAQNIILREINTKLNYISSHDSLTKLLNRRSF
SNNVSEKMRMVGKSKKIATLILIDVDHFKHVNDKFGHSVGDMVLKEVSNIIIKHIKTTDL
ATRWGGEEFLIFLFESSINEAYVLAENIRQEIQNKVIVTDKFQIQITASFGISLLKDNFS
KSFDTSFKSADVALYKAKNQGRNRIVIAS
>A0A1J5MWR8|diguanylate cyclase|EC 2.7.7.65|Pseudodesulfovibrio hydrargyri|TrEMBL
MAAPPEKQAEKAAEHLPRQPGGINPRSLIFKFLVRILPPLLVGILLLMLVLAHYARRDIM
DKIDTDVGIFATATTRVLDGLLWNYQTEEMVSALATISSNPAMLGAEIYDQKGDLFLSYG
ITPEDRVSGLKTLWRDIYRRMPDGSRVDMGRLAIHYTYTFAEKRFRQHFLLQMFQFLLII
AVTLSGAVYAFSRTVSRPLKALLAAIRTTGETGRWTEADWRSDDEIGEVIDAHNRMLRHI
AGKEAALADSEKRYRQLFENALVGIFLISPEGIVVEANRNAANIMGYESSEQMDKLNVLQ
HYVHREDRDRLWETLKKDGEITRFRIEQIRTDGSRIWTEVSGRLTPDGFFNGILQDVTDL
VEAAQVMKERDELHRAFFEENKAVMLLHDPLDSSIQFVNPAACQYYGYSNEEMTSMTIRQ
LDCMTDEELYEELKEAARERRGYFKQVHTLKDGTRRDVEVFTGPVSLGHRQLHYSIVHDV
TEKRRLEARLQRMATRDQLTGAHNRHAFFQRAKSELARAKRFGHSLAVLMFDLDHFKEVN
DSYGHAIGDEVLRTFALRCRAGFRQSDVFARMGGEEFAALLVETSAERAAEAAERFRQMA
ASRPIPTDAGDLTVTVSIGVASLDDEDSINDLLKRADEALYKAKQSGRNSVVRL
>A0A1S8TCR0|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MEQTNTRKKIDILMTLLIAYFFALCLSIKALGLDDSFENYLMIEFVMMIALISYYSNITL
ALVVTLVTDFGYMSYKLYFYFSNNVSVDISTYYWIILLPITAVLVSLVSRNIVILQKENE
SLLNENSKLVMIDEDTNIRNQRALLIELPIYMKMSIRHKVPVTLFVVRIKFAEKLKSILG
KEEYKALLIQASEVFEKSLREEDIKYLIDYRTFGFLTITDIDGAKVVKERFKENVSKFDF
SKESFYKNVRVDIQIGSYTFDNSINDPLEFIKLAEKELEYDIQE
>A0A5A9ED94|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MMRNTKEIDTILIELNKSIDAHYKWLVKMFRCVVSSDVTQPDIMGENSHFVCRFGLWLNN
QSRYNEDDCSYVSKISATHEKMHLLGKELLLAIVEKRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDVLTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACLAGLRLCRLIGQKKIPY
ADGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENERIALVDTND
GTSYPLSA
>A0A7W6ZXG6|diguanylate cyclase|EC 2.7.7.65|Rhizobium leucaenae|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTAEDGLQALAICDSTQVDLVLLDIMMPGMD
GFEVCERLKSDPRTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLVSRVKSLL
RLKTLSDELRMRNETARNFGIDDLLRIGEGRADENGHVLLVDGRANSQERIIRALKPIAE
VTVTSDPQAALFEAAEKPFELVVVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
EMIVRALDLGINDYIIRPLDPNELVARCLTQIRRKRYNDRLRASVQHTIELAVTDALTGL
NNRRYLDNHLKILFNRSLTRGRPLSVLITDIDRFKQVNDTYGHDAGDEVLKEFAARIRST
VRGADLACRYGGEEFVVVMPDTPPEVSASVAERLRAAVETMPFTLREAGVALNVTASFGI
SSRLETVETPEQLMKQADRALYEAKHGGRNRVVAAAA
>A0A1N1MM52|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. abscessus|TrEMBL
MQNPPSVETGYQYDLVTNALRDTGQLGRLKTGIGLLCFVIVFLQGVTQFYPLGPHGIWPR
VVHGITAASAVVAGLCWLSFSWPGRRAMAAFVVWADVALAVGAALLSDPTARICAIVYLG
PVGLLPTFFLSRRALVAHCAFATSLLGAVLAVNVLSGGARMFEQFFYAAPVISAIVLVPA
VIQLVLEGGRDSILSAALAADRDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDVDG
LKELNDTHGHGAGDMTLKAVADMLKARTRVGEIAARFGGDEFLVVAFPGRGEDIESTIRR
VSAPRAGIDYWTVSVGAAWQSRTGNKVDLESLVQQADHALYEAKKTRGMLDPQR
>A0A0D8FUG7|diguanylate cyclase|EC 2.7.7.65|Ferrimicrobium acidiphilum DSM 19497|TrEMBL
MRLRGFFAIVVGLGGVAVSAVGMRSGHAQDGVIGASVAFVAVLLGLGATARRRKPDENGE
ASADALVTVEAINDDQNVDLVEVAAEAAADPITDPLTGLMNEIFFSGLLSTKVATARRRL
WPLSIVLLKLVMKPGVTTEAADAAIVAFVGVISETIRTADVACRVGARSFALLLDDTDED
GAAWVAERIQIAHAREGDSPIAKVCAGVASYPSHGIEPAEILITAKSALKQASDNLELPG
LGRVIVAPQRPI
>A0A220W633|diguanylate cyclase|EC 2.7.7.65|Sphingorhabdus sp. SMR4y|TrEMBL
MQQSRASNDQHCPNCYILEQEIVALKADLAEMKLRAYNDVLTGLSNRRFFVENLEERVER
CRRCGDNCAVLFLDVDKLKAINDEHGHAAGDALLVRLAKILKSHIRGTDVVARIGGDEFG
LLLDNLNGDQVADKIESLLQDLARENIVHEGQKLPLGASIGYCFVGPKDTTDGLMSRADA
AMYRAKDKPA
>A0A1V5ZWM6|diguanylate cyclase|EC 2.7.7.65|Synergistetes bacterium ADurb.Bin155|TrEMBL
MESHITEIQEWRNLLQYIVRHDPNAIFVLDRDMRFILVSERYLQNNQLERDKVVGRTFAE
ISPAIYEKWYQVHRRALGGETLGSEQDQLTRPNGAVDIIRWWCRPWYEPDGSIGGTVFYS
ETITERKQMERALFLEKELFRTTLLSVGDGVISTDDEGRVRLMNHVAEKLTGWKAEEAAG
EDFGVVFHIIDESSGERAPDPVRQVLEDDQPVELMEDSVLVSREGLMVPIEDRAAPIRDR
DGKTTGVVVVFRDCAEKRQRIKEIEYLSYNDQLTGLYNRRFFEEELRRLDVPRNLPLSFV
MADLNGLKLFNDAFGHAAGDEKLRKVARVLREECRADDIIARVGGDEFVILLPSTGEDHL
EPMMERIIAAVSRERVENLPISASLGGATKTDPSESAEKILHRAEDQMYRRKIFDKSNYH
SGLVKLILEALYSRLPTEEAHSKRVARLSEALGRVMELGQPKIDRLVSAAVMHDIGKIAV
RGEVLEKKGQLDESEWEEVKRHPDVGYSILGSANEYNLLAEIVLAHHERWDGKGYPRGLK
EEEIPLLSRVIAVAEAYDAMVSESSYREAMSREEAVAELRRCAGTQFDPAVVEALVEKVL
GKGFLFD
>A0A087CDQ3|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium psychraerophilum|TrEMBL
MLLSATMPLAGRTLNLQGERAVAIHKTVMIVDDDKALAEMLSIVLEAEDFEAVICLDGVR
AVEMFPIVQPAIVLLDVMLPGLNGVEVARLLREHSDVPIVMLTAKSDTQDVVLGLEAGAD
DYIAKPFKAAELIARIRARLRSVAVPAEGDGSILPDRIVKGGVSLSRSEHVAMKFGKQLA
LTPVEFDLLYTLALFAGEALRRDQLLRKVWGYEHAGDTRLVNVHVQRLRQKIEDDPEFPS
IVQTVRGIGYKFVPPKMM
>A0A140L704|diguanylate cyclase|EC 2.7.7.65|Thermotalea metallivorans|TrEMBL
MIRDLTHRKYYIIFKITTFVMIALLNIATIKIWNYKMVGILTTLFLALNYIFGLQKVPIQ
SEQHRFKIKIIGNFLLVNILLFYIGGYQNASYAIFHFFIILTAAMMYSSLGGLVILGICF
TIALKMVFTDTNILNSFIIHSYVYGGAFVIGYFCRMEGIRKKKLDHKIRELEGLYKISKM
IDRFPGTEEILNNITKIVAETVNAEACLIMLYDEEKDLLAAKAGYGVPKEAFQQMIFRQG
EGIERQVIENKGRVTCKEEECFHIYRNISQDLWEIKTATAIPLFLRNKIIGTLSVYDKKG
GNYALEDIELLDMMGSRIGMILENDSLYKQLRNRAIQDGLTGLYNHKQFYERLKVEIQAA
KEKGYKLYLLMIDIDRFKAFNDRYGHLVGDKVLVQIAKIIKNSIRDTDYAARYGGEEFAV
ILPNTDYETAAMVADRIRDNVKKAAPAIEQLQKEQVEITVSIGIACYPNCTNDITNLVDI
ADIRMYKGKEMGGDRVIA
>A0A7D6YAF2|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGSLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESINLTYTAINIIEACVGAVLLRKLLPWYNPLQN
LNDWIRLALGSALVPPLVGGILVHFLVPGAEPLRNFLFWVLSEAIGALALVPLGLLFKPH
YLLRHRNPRLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPPSMTPSNMMVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLINGEINSYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRAHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHAIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDANYQTAEVMSQADIACYASKNSGRGVV
TIYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSG
IGIDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A4R0F7G9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4216|TrEMBL
MNTESIATLAAQWKSVCQGFSTTDLNDTFQFIQAHSQTLVYEFYKNIMQEKEASYFLSDD
MVQNRLKTTLNQWLIDCFNVPLQQNFIEIVEKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFLLQTEQVQENSLLIAAYIVQILGFASEIMCRSYEVNLEKNNDIKHTYRLFSAMQDVAS
QKDRQRSSLLDWENELMFKVFSNEPKFTHPLLSKSEFGLWFIHKAAYAFTGSEQVSVIID
RIHQIDLLSQQVLNAAEREQAIQLIQHIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLHTIVSREINFSRKNNTPLSLLAIDADYFKRINDKFGHAAGDSALKFIGEVLLDSI
KGSDYAFRVGGEEFLLLLVDSDLVRAQEIAEKVRSRIQETTIRTSMGISFNFTVSIGCAL
YDGHPDYQRFLDAADAALYAAKNNGRNCIQVTKQAVKA
>I0L1N6|diguanylate cyclase|EC 2.7.7.65|Micromonospora lupini str. Lupac 08|TrEMBL
MAAATAVAAPLTIAFADADGLNTINADGGHAAGDQYLKAIAARLTHAAASVSAGAQVART
GGDEFMVLVPRAAATALRDAIRIAFVGPATVAGRRMPLRISVGIAVSSGGIARKALAQAD
AAMFTAKRVGNQTLVYDADRDGVPELDGTRPQVRRRDITPDRDTAARATDGTAPTTRLVC
SLDEAAAIANALWLAYDRWAAVLQTEPSDPAASTAPAETIDVTPTAEGLDRTAAFAETEM
AKYAGLARRISALIDSVNERS
>A8CYY7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Weltevreden|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0Q0GBD2|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MVRIGKLTVLFFCILFSPLVHAYPLNTDKITLKDDDLWRPVTAFNTTPSAQQVITSYKNS
SEISTLLGKSGAVVTKVALNSPATGDWYVLPQANFIDVGLAFWQTEQGDIVKLADFSQTH
VNQQAILMHGQAFKLPFFEPSKGYLWIYLEAKHYPTPVDLTILDEGAFLHHQFYINSISL
IAISVMLTLAILALVMFLNVKQKVALFCAGYVGLHGFGWAFASGAVNAVYASPTFNKHYL
GMYLFAFAVSCAGAFTYYLFNFYKEKTNKLTRALKYFSITAFVCGVCSLLMPFYVVFYTA
HFLAAIWVTLSLTTGFAMLSLNDFRAKYFLFGNVLYSLSLVVYVAFHFNLINATSAEIFV
LIALAIDCVCILLSLSEWLKLKHQAFNTLLYESRFDPLTQVGNRLLLDDELVKLAHSAYI
IVFIDCDGIKKINDGLGHAKGDAFLINAAKLMTHHLAQDGTVFRTGGDEFIWLCKVKNKS
HLPQLKTTLTQKLKALHNTIQRQWPQSGISYGIASSDECQNHTECLTLADQRMYNLKSAH
KLKVC
>A0A1V5NQR0|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin373|TrEMBL
MGVENAVYIIALFIAGVITGALALHASRGCAKTGVRAFMCLMAAIAVYSLGYAFELSSTT
LTEMLFWSKIEYIGISVLPAFWIIMAVQYVGKDRWLTRPVVFALFVIPAITFILHCTDSY
HHLYYSAASVNTDGPFPLLSITKGPFYWVHTSYINLSLLCGNILFLQKRLQTATVFRRQI
TVMLTGSLIPWAVFIIYLSGKGPRDLDLVPFGFAFAGLIFAWGLFRYGLFDLAPIARDFV
FEGMRDGVMVLDEQNRIIDFNPAAQKIVQNLSVNDIGNSAEEVLKHYPELENKISSNEFG
QAELKITQGGQLSYYNFRLWPVKNRRNRLIGKTVVLTNTTEQVLLLDKMRILANFDNLTK
IFNRSYFLELSQEELSRAKRYQLPVSIIIMDIDHFKWVNDTYGHKAGDLALQTVAGVCKE
ALRANDLFGRYGGEEFVVFLPVTSPEMALSVAERLRKNVSCSPVLLDNYKINVTASFGVF
GVENAEGVELDDLLKNADHALYKAKSLGRNCVMLAGVSTTPSP
>A0A5C5X1R4|diguanylate cyclase|EC 2.7.7.65|Thalassoglobus neptunius|TrEMBL
MLERQAQLILKPGILESGRRFRHTQIVADVLAQIDLDSHRFLLIEDDEGELLGIVEVEEL
HQRVASPNFIERRRWCDMALGSAIGARLDCYQKNQSEDWKKLGADSELKIDGYTVSTAND
DMAALMIEDELYLRWSSIKRILDDALVDPVTRLPNRLVFERRIEEEWQRLTRNSTSLCVV
LIDLDFFKQINDEFGHSVGDQVLLEVGNVIRSQLRSYDLLVRYGGDEFAAVLSGCTASQL
NIPIRRIQEGVRKIALQSLPELPTLSLSIGAAMIRSQLDSPTTEDLVNQADNCLYAAKQN
GRDCAYVLDMTRNGAVPTEVFGSNVMGLDDSQPLL
>A0A8F7MFT3|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MDTKIFSVNFRYINTLIVILTTSIFIGLITREYRDLERYMGYVAENGRSALSHAEYINQN
MAFQLSRAFSVLPASPGVQKNKRDKVCEHLESANGVQGLNLSNQTYRGLNGTLQTRNADC
QVWAEDVPALSVIQNDHRISVSKYTFSSYRGYIFNNIRYYIDLINNYIYINKIIDVNKYQ
FDNWLVRDDNVIDITRSAHTISIDRRALNDLLHGESITSHIYRDGYTKKNIISMLTPVFQ
NGLIKGIIVTDVNIDDLTTAFCTADRPVLWRFLSLYVTDESTAGDIYFHRSILKSINIIK
YQANLTPLYKLNVKLDLIYFIINNLWLVFIYALSTWLLCRYTKKQMARHAELSKDNITDT
MTGLYNRKVLNDALSHKIDAALAKHIPVTLVSIDSDGLKKINDTLGHHMGDKVIQSLGRA
IEQSIRKSDYGIRAGGDEFLLILFDTDYAKSLDVIARIKENLRHTDKDKRVSFSHGNYPL
EAGDSLESAINKSDQLLYVHKRNKHAVPGK
>A0A087DP73|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium stellenboschense|TrEMBL
MTRILIVEDEESYREPLVYQLTREGYDVSAAATGEEGLELFTKGGIDFVLLDLMLPGIDG
TALCRRIREQSRVPIIMLTAKSAEIDKVVGLELGADDYVTKPYSFRELLARIRAVMRRNQ
QPSGAGDGAGAGDDLPLVCGDIAMQVGQHQVTVRGENVFFPLKEFELLEYLLQNKGRVMT
RHQLIDRIWGSDYVGDTKTLDVHVKRVRAKIEEDPSHPKYLTTVRGLGYKIDKPAA
>A0A485BVA3|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLLKELIIFDLLATPIWVVHPFKERILYGNPASRALSGDMSLDQMRKGTFSTCPEVSLQN
YLYYFKNIAEIFEVWTINSLDGQTSIYCKTTLIKSEEYDSLILFEAVKLLEQNESINTTS
RHYQRRSNGFFSRFFMTNSAPMLLIDPHRDGRIIDANIAALRFYNYTADEMRAKHTWQIN
TLGRTFFLSCATSQACPAAISRSTSPIFLLTAPFATFKPTPVR
>A0A7Z8Z9P7|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLINSRPLLNKVLLYLLICIIATGLIHLFASSLISRTSTASPVLLPVLTIFLLILHLTIS
CFMIMKYWCVRERLYLTAIACAFAGSALLMLGTLSGHTGWFLCSQGPMPNANDALIFFTF
RNAMMVILFTIAIVLYRFRHSPRLTKRVHALILTGCLSFTILIITLSWLYSSNHPLLNIA
LVDNLSHQFSPLWHNFIGRILVASWLITLTLLIYISRLKNIFWYSGAFFCSAYIFTLLVL
MPQSDMLYSWYHARTFEAISTLFMLFVLLCDVFTLYRHSNDKYLTSYQNSIRDPLTRLHN
RSYFYDALNAQLTKASASQPLSVIVSDLDYFKRINDSYGHVQGDKVIQFTADVLQKNVRP
QDVAARIGGEEFALLLVNTGPGDAGAIAERIRLAVNERQDALPERMTISAGVFTAVDGSL
SAEECVKRADTAMYEAKSGGRNRVVVWSEVK
>A0A7Z8ZCD6|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MLLKELIIFDLLATPIWVVHPFKERILYGNPASRALSGDMSLDQMRKGTFSTCPEVSLQN
YLYYFKNIAEIFEVWTINSLDGQTSIYCKTTLIKSEEYDSLILFEAVKLLEQNESINTTS
RHYQRRSNGFFSRFFMTNSAPMLLIDPHRDGRIIDANIAALRFYNYTADEMRAKHTWQIN
TLGRDVLPIMRNVASLPGGHKPLNFTHILADGSIRHVQTYAGPVVLYNIRLMLCIVHDVT
EEVHLRRELEFSASHDPLTGLLNRREFYRIVDSAAFKPTGFCLLLVDVDNFKAINDSYGH
QKGDKVLLTISRILESTVTHQDKIYRWGGEEFLLFLPERSIEMALQMAESIRLAVSGYQL
ADHPGPVTVSIGVADHQDDEEIDQLFNRVDKALYAAKKEGRNQVRLYLVEKY
>A0A8F6Y6S0|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sanguinis|TrEMBL
MKRYRSFGAAALLLFLCLPAMVRGEARGDPWAAWQWASFTRQGDAVGLPHITATAIVRAS
DGTMWIGTRGGLTRYDGQRVRSFKAQSGNTYSLPDNYVRSLLALPDGGLLIGTNVGGLAR
YEPASGRFIRLKASNGPVGSRIFGFTPDGSGGAYIASDGGVHRYIAKTDSIDAMSSVAIK
GRDGRPEGAFAVHRDADGTLWAGCEGGLWVRPPGARRFQPTALVDSTDSRDIWSIMRDRQ
GRLWVGTGSDGIYMSGDRGWHPRFIQSPTLSGAAPLIGHRTIRAMVEDARGRLWAATDGM
GIVLIDPANGFSATGLRHLTANPMSLAGDTVRALALDGSGGVWAATEMGASRTQGPGGGI
LRIGSAMPDPRMSLSDDNVRGLMVDRHDRIWLGMSNGTIDALDRKAGRVRRLTLQGQHGG
QDIKALLEASDGTILAGARGVVAIDPRTLAQRPLSVEGLGDLPVISLAETDDALLIGTYK
GLFVRRHNGQVRVFEHDANDPHSLPNNEVINIVVDPYGAILIATPAGIGRFDLTRGMFTI
FSSRSGGSGSLPQDYVGSVVPIGRDIWVGTYGGVAQGRVAPGGWRFRAISEVQGLAGDNV
ASVVLDAHRRPWVASAGGISVIDPDGRTVRVMSKRDGLSASAFNQRTAARMADGSLLFGA
PDGLIVLQPDILLARLDHVQPGPLIVSSADIDGHALAVDSTVNALSLRWGKDGRTLRIGF
ALADYDAPEDTRYSYRLDGFDRTWMTVPAGTPASATYTNLPAGTYSLQLRAYVPGLGART
VERRVEITVDPQWYESWPGRIGMALIFLLLLGATFWLVTAVIRRRARMLEKMVAERTSAL
RTANEQLDRLASTDPLTGLANRRTLMTALQAARDHAIAQDEGFAFALLDIDHFKRINDGY
GHSAGDEVLVRMAARLQNGIRAGDVIARYGGEEIAILFPGTTLDSAMGIVERLREEIVFT
PLLIGSQAINVTFSAGVTDWRPCEDVAAMIRRADDALYDAKRNGRDRVAQAA
>A0A1V5J3D2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA052|TrEMBL
MRYTGNDDTGAAYSRNQAISMLEFVRRVKQVFVGSVLVVVALVFFLVFRPMEAELKHSLT
DVFEQMSRTNRYIIENTIERCIEGAKSLSSRTMIKNAIGQYRSGLMSLEELKTYTQGKYE
DGVSAIDYIVLAQRIVDDDIVASYRAGDEVLDMSYTEIGTQQEAAIVPKLVLSGERVYAA
MNSPVKMENQVVGYDFVIYDMTKQIEALRSRNMEAYLMDDRAYQELLDAYATTEHNGATV
LTKDGLVYWVAPIANMYFASTQEQSTLYEPITRLGHRIVIGVTAVFAGYTLVVYLYIFRY
LRRELGSLESSRDAYKEMAYIDHLTGAYSRQFLDIWDKSVRSYRENYALVVIDVDGFKEI
NDVHGHSTGDRVLQHFAATIAKSIRRSDVLARYGGDEFVLVLAGVDTEGARSLLARVEDR
LTVRVHSSDFIRIRFSYGMSMLENDDDLKESLERADREMYESKRAKKSEH
>A0A399EGE0|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MSSDTPELSPRPGQASEPRERLRLLLGWCEAQGDGDPAGHLAAAREARELAGALGEAGLE
GAAWLEQGYAHTALGDPARALEAFRQALARFEAGRDLANTARCLRGMGVVYDGLGDFERA
LAHFIDSLELFTRLGDPAAEARALNSIGIVYSRSGHPEEGLEYYRRAYEAHRRLGRLLEG
AAALSNMGINLKNLGRLEEAEGVLREALSLSAPSERRMRGAVLSNLGLVLEKLGRLGEAE
DCHRQACGLLQGREFPALAVEAALCLGRFYVAQGRLDEAGPLLRQAEELSRASGNRPKEA
EARLALAELHKGRGEFEAALGHLEAGRRLEREVFDAASDRKLKNLQVSFGLEQARREAEL
ERRKNAELERAYAELEALHAALKESDRQKGALLQRLERMALEDGLTGLFNRRYLDEALAR
EFEHSRRHGRPLSVALCDLDNFKRINDRLSHMVGDEVLKGVARLLREHARPADVVARYGG
EEFAVLLPGADAAQARAACEKLRAAVEAHPWHTLHPELRVTLSVGVCSDLSLENHERMLA
EADQRLYRPSTGARTRWSLREGAVALANPAMAASRAPGEGA
>A0A399F6A9|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MRPESLSRSLKRKFYVFGVLLGALTMLITWVFKAGQSPFILYGYPVLIAATLAVGWLAWT
RSQFIARLEGGLFFAISGFFLGKIGFLLLFSQDRQQAWVEVQAGYWALLFAYFFAFLAFS
APKALWLSLTVNAAAFAINLAVLLPSVARGGAADELVEAGRFGVRTFTLILLLYLLAQYK
GALSDERRRGVELFAQARTDPLTDLPNRRALEERLRERVAQGMPFTVLMIDVDHFKSFND
RHGHAAGDAILRHVGQRLRRALREGDLVGRWGGEEFAVVSGEGSLAQAKLLAERLRQHVS
ERPIDGQYAVTASFGVAVYEPGESLEELLERADTSLYQAKHGGRNMVVG
>A0A399F387|diguanylate cyclase|EC 2.7.7.65|Calidithermus terrae|TrEMBL
MGSVRRSAWLTAAVALVLHLLGHAGVLPLGFPEAWMMVALATLTSVLGYRWVLPLTAGAS
LLDALLSTGQSLLELTALYAVSSLLAAWLGARLRHAFRERKRASHLLNLLIRAQKELSGL
DSRGEVLEALPAILEAYGQGNVSVWEPSPAGEGFVRVAASRSFPQDYRTIPEHGVVGRAF
AQRRSVHVTDVASESDYVPVPGRPARCELALPLVEQTEAVAVLNLEYPEPLGEEALQALL
EFAEGVSRRLSRLVERTELSLLENLNRTMYSAESLPGLGERVLALLGQVLDFDSGALVRQ
EGSRLRAVTFWGDVHPQERALLEEGIPFGQGLAWGVHRTGQPVFNDKYATDERGLQTLKD
AGVQALVLHPIPLPGSARVRFMLGFQSRRQRHWRQSEKELLARACRAVGLALEGMLERQH
TQTLLELQQTVLELSPEAAYHRILQTAVAMVPGAEAGTLMARQGEVFVFRAVHGFSLEDL
HGVEFSLSQQQAWHGDLESWERGLPRVRSSAIVESSLESGLTEGKVRDARVREIQANLHL
PIRYGGEVLALLNLDNLHDPLAFDQDSLRAAQLFAPAVATLLHDLRYRQRLEEAALTDVL
TGLLNRRAFDLRLSEELERARRYAYPVSLLVMDLSGFKAINDRLGHEQGDRALQAVAQAL
RQQRRNGDSLYRWGGDEFAAILPHADLEGAVAAGTRYHRAIGALEVGGMRLGVNIGASCF
PTDTEDSESLLRLADNRMYQAKSRGMPLSAG
>A0A1E3GI13|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 51m|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A2H6G326|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin11|TrEMBL
MTVLLTYMVLIEPDLQQLSKFVLESAERLDANQFKASTALIGLLEELRKASRGGDSALET
QLVIRDKRLELSWNGEKHLVVQLESDPASVVIDELGRQLKYESELADPELLRVRNEKISL
NLENAKKKAAEEMAELEADLASKKRKLWVASHRAETDSLTGLLNRGAYDARLKVAIKSCQ
KEKSPLCLILLDLDNFKEINDSQGHQYGDKYLKNIATIMLGSCRHQIDYAYRIGGDEFSI
IIFAEMKAGYRIAEKILVEFSYKVSIGIVEMGASDDVEKLVSRCDKALYEAKEEGRGQVI
AA
>A0A0R0A404|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas pictorum JCM 9942|TrEMBL
MHSITAVSSAIDTENPALVAAWQRGLTEAGPAATQVLAQLADTGAAEMAVHFYQVMLDDK
RASRLLSHDQVRTRLQPAMQRWVRDLLLATPERVESLIAAQRVVGDVHARVGIPVDLVTR
GMRVLKQRLFQLISEQAGHSEHAHAAVACLTASFDIALECMTLAYSNARERSSRTDAAYR
LFSLVQNVGTERERQRALLLDWENTLLYALASQNETPEFQSLAGSEFGLWLTHKGIPSFG
ESSETQQICALMAAVDQTLHDTLDTKRDLKVRSAHLQEVRARVGQIRNLLGMLFERIGEL
DAGCDALTNLLNRRFLPTVLRREIELANKNKAGFAVLLLDLDHFKSINDQHGHEAGDRAL
QHIASMLSQFTRGSDYVFRYGGEEFVVVLVAVDERQALVIADGLCRRISDSPVLLADGQP
LAITTSIGVALYDGHPDYERVMARADAAMYQAKKQGRNRIVLADDSLPEAPDRASLQNR
>A0A0E1LVU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1303|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCVLSLAFLSCLIYFVITVIIIQQIIEERLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVFGGPIVAHILSSHYESYNLHIA
ELTNENGQVVWKASYVTIMIFMWLTLLSVNLYFNGLRYDIWNGVTVIAFCAVLYNISLLF
MSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRDPLTNIFNRNYFFNEL
TVQSASAQKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVNIIGKSIRPDDLLARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVRDVVNFCESP
>A0A6M1ZQN1|diguanylate cyclase|EC 2.7.7.65|Chlamydiae bacterium|TrEMBL
MRRNKITILLIEEDPENANLYKKFLKRGEMSGEVTHASSLEEALPLLSQHTFKLIISALF
LSDCSGLETFHRLRKAAPDTPIVILTRPIDEELALKTVSQGAQDYLPKSEITAQSLNRVS
RSAIERHTLRESLKALTFTDELTKLYNRRGFIALTKQHIDLALRQKHGFHLFLIDLDHLK
GINDTFGHLEGDKALVKTAESLNKNFRISDIISRIGGDEFAVIAINVPHQKGHLLKNHLL
EIVKEWNATKEQPWQLSLSIGTAYFDPSQPTTIEKLMKLADQEMYADKKIHHEK
>A0A5C6A494|diguanylate cyclase|EC 2.7.7.65|Rhodopirellula pilleata|TrEMBL
MLKTVANLETHLNQAIVPTHVGGTDAEATMHRCFANERSEHVDKEVCLVQIYPADVVRGM
MLLEQDAFVIGRDPASDLVLSDHSVSRQHASISLDRDGYYAEDLESTNGTFVNGNLIARC
RLESGDTVQIGTFIFKFLSAGSVESHYHETIYTAMTRDGLTGTMNKRYLLESMQREIARC
ARQRQPLSVVMIDIDHFKSVNDSHGHLVGDEVLREFGRRLLSVCREESLLARYGGEEFSL
LLSSTDGAEAIEVCQRCRAEIANTRFSTSAGPLAITASFGIGCLPVGQPMPVTDLIKIAD
DRLYDAKKQGRNRVVI
>A0A151API0|diguanylate cyclase|EC 2.7.7.65|Clostridium colicanis DSM 13634|TrEMBL
MKEITKYESLRQQVKAYERIFDTVRVVDPVTKKATIYKDDKDISENITCYSRWLDGNECK
DCIIIKALNHKKTFVKIQNNADKMFLMFAVPLELNGDIFALELIKDITDILVFETVYQCE
SHELRNIVQDLNTLIMKDTLTSLYNRRYIDRILPEEIARCDDKNPLSIAMIDVDHFKSIN
DTYGHNAGDIIIKKLGQILSNSIRNDTDWAARYGGDEFLICLPNTDNKKAYKVLERIRKN
VEKINIKIENIKIKVTVSGGLYTLNNNILAPVDLIKYADDKLYNAKEQGRNRIAS
>A0A549VAU9|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
MFPNTMNDENFYQKKAVPNEAFISLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAEDPLYSEFTNIKTDAILAGMWVGIMGANL
LPSTALLMIICINLMGAGGVRLFIAGVVLMVVSCLVTLQLTDIPVVFSSTQLSVLLSLPV
LVIYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRQQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
PAASAIAAMSRVHERLSQLRLSCAPQVALRISVGVAPLTSETEHYREWLKSADMALYKAK
NAGRNRTEAAA
>A0A1V5Q6N9|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MNKNIFVRLLTCLAAVVLFFGGTQFFYTLYSRYQLKKNHKEVREYVESQLNYDPETIDEQ
LSTMQMWMENKYLYPEDYGMVYERASNIYKFRDDYANYARCFGYAIYYLEQSSDVDYTVN
LELDLAMFYVVNNNYDLAREVVDRVLANMDVDNLQRPQVRSYLERFKGMLDAKDGNYDQA
AEQILLAEKIIDGAPYEYYTDSYRGIDKVNLAKIRFYQGRYDEAEELLDELDGSELFDQT
EYASIMARDFVLPYLETRIYLSLEKGEDVTELLRNYVEQCETYGYNQWEVQTLMYVKDKL
GLEDTDEYREIIAMLENSYDSSARYQGTRYTNLLNGIINDSYEHIKESYELKKNQRTRFL
IYAALAVFLIWSAAFVWAFIKKSRLDGLTGIGSRGAFNLQMNKNKRAYGIIMMDIDNFKM
VNDTYGHQKGDEVLVRLGQILMDMKSPDIQPFRYGGEEFVLVVYSRSLPLVVNIAEHVRK
IFEAQEWDFGAHITISLGCAVSDDGDDVVKRADDNLYISKKTGKNKVT
>A0A549VAZ3|diguanylate cyclase|EC 2.7.7.65|Citrobacter youngae|TrEMBL
MEQVDPVNDTLLLTEWRALIRQTSPDVHTILTGLSDDEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAYEDLPLLLAKQREIGVVHARIGLPIDLVNRGARKLK
EELYQLLKSKADYSVSLLSDAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGLPSGDLVFLADSDFGMWFSHKGKHILGSGNLL
AEMESVIAEIDNRLTQAFSNQQQPGETERMSLLQDIRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHSRRPFTLAMLDIDYFKQINDSYGHNTGDMTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRKKIAELRIAASMTESFSI
TVSIGVAEYDYHPDYKQLVDKADRALYLAKSHGRNRVETYRE
>A0A841KXZ1|diguanylate cyclase|EC 2.7.7.65|Anaerosolibacter carboniphilus|TrEMBL
MFRDLFINSTILISFVFIGSHIFKEDDLSNNSSITTKALTGIGGGLLGITLILFGVKIEI
LSTIIDLRYLAIIILIRYVGLLPSVIAAVIMITFRITYFGITKASIFAVISMILTVIGCN
IIWRIKEKQFWKWIFMNMYSVVVMSSCMYVLLRNSGKTFVVITSYAAVSMGIGITLYYLL
NYVDTVNIHYRKFKEEAKRDYLTGLNNLRQFEYSMNELIYGITTNNEKLSVLIIDVDHFK
QVNDTYGHLAGDIVLKEIGKVLLNNCRENDIISRIGGEEFTILLPYCPHKQALEVAERVR
SEVQVHQFILPNNTVLSITVSIGVSTYPETVMDPAELIHKADEGLYLAKRSGRNMVCSIQ
>A0A1E3WQK9|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MVRLGLLRGFILAIVSVFATCCLSMSAYASEQYRVAIEADDVVTRVLFDAVSQRFEVDIA
YVYYPSFNDILTAVESGESDFAANVTYTPQRAERFDYSSPTNIEYTYLYSYTNATLETIE
RVGIPKGTIYGELIKKYFPSLTQIEYSGHQQARHLLDSGQVDGVVDAINQLKPMLLAGLD
AQLLNHQISIKPVSLIGTKDKFQSQLKSFEQHLHSAPVQKLLRETVNQYQFDIRQKSLRD
LVVASGIDRSRPLKVKIEHAGQYATYHDNGQVTGITPDVLFSACDILMLNCKLVSRGDET
WEDMYADFLAQEIDLISPFAKSEPRKQFAYFSVPYYQSTAIMIKREGYKNNVYSNVSELI
VERIGVVKDDFYQELLESLLPQKTLITYRNAEQQIAALLAKEIDYVIITRSNYNKILRES
KTLLPLTEDKLIGEFYTSNVTIGFTKNARGKALVPLFDRAIKMLDLEKITNTHYVQPDWK
AALQSEQRLARRSIAVVALGLIGSILVSLYLHHQSNTDNLTRLKNRRALQRRYSKDISPH
LTLVYLDVNNFKPINDTFGHEIGDQVLKHIAKQISRYWKGQSYRIGGDEFILIGSVDSVT
LSYALLNLQKLQFTSQDHRITLDVSVAFGVSKPRREAMTLEDVMHQADLSMYSHKRKVTE
REINVAKQQIEQELNMIQP
>A0A829L6S5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907889|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1T4M6B4|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MTVNGFLKKIFVYLKLFTLFFMLCSFSYYIYNIYHIEKLQNMYIRTLNNVYSVARRFGSF
YNNTDTVALDKGTYIFNGVSVVVNTPTKAKILSKGINKLREKINDLTDDNTWTVAVFETS
SDYSHFDPLRPAYLNGYDKIAINTIVKSEDLIDTYRSFYGCNIKLTDIYKETGTDKIIRT
IYYPIYNNKKLDSLLAIDIKNSAFSNILTTFNNKNMTIISMDNNNIYHTSELLPCSTVNP
INLGLNLFTLLKATFVPSLLLMLLYHSLIQLIANKQFILRYDQMTRFYRRDYYESKLLNQ
HNFNLLIIDIDHFKNVNDTYGHEVGDDVIRTVTKRINNCIRKKDIAIRWGGEEFILSFTN
MSKEQLKIKAQKICDAISLCPILDMNITVSIGGISTTNMHFNEAYKAADQALYYSKNNGR
NQATII
>A0A1B1NSJ6|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MVSHREEWLDFLLNSLPDHVFILDPNGRYIDSYGGSHYAPGFDAKRYIDLCLDQIFSAAK
AAEMQGYIDQVIHQQKTLVVRYNVQLQDHLLLSIDDIQDFELPEESWFEAIINYVQPSAR
NHTAQVMWSVRNITKAHQLEKELKKLSETDELTGVLNRRAFMLELEQDFQQQSANNAHLT
CLMVDIDHFKDINDMVGHLSGDLVITQVATICKNVIRGSDYIGRLGGEEFGIILSHTNAI
QAFDIAERIRLSINSTPCHVDGHEIYPTVSIGIAELNSDSQSVKALLVEADKAMYYSKRT
GRDLVTIYHPNLPDLKTNSTSKARILKAS
>A0A1T4UDB5|diguanylate cyclase|EC 2.7.7.65|Photobacterium toruni|TrEMBL
MKLRLKSSLALLMLIIAVVPAAIVGGLLLKQQSDVEENYRIDMLNRLSHTIEQEFDYRFS
LLSTSLDVLSRDRLFVQAIDNFFLAGHVNNSLGTLVRNTPLIQAAYLVDDQWNEIENYNG
IYGLSSFFKLENSFTPRISQHNKKGKQWVFYYNDEDLMPLKFNPTRRGIIVGVPIFQSMT
NGLKRKPLGYLIVVVPIKNIIKVLQPYLKDGELVVFTNNPKGGDNKLDDKNNIIISQGVI
NKLTPTINKIINIKLENKYISEPIEYTMAVYIDKYIGKSPYINSLKYITIFGVIIIFLSL
FSAGMIYRWIARPLGGLMEIVRAYSRGEYKCSDEELRFTEFVMVERLIRTMSKTIQAQVA
DLAVTNSELNAAYLEKEQANLQLVNFNDQLERKVKEKTLALSHSLLREKNQRSMLQSLLA
FSHDLQAGNIIETIMTQVVALYPMAGWAMRTYVDNNNVWVCENIYKVDLDVKEVLPENHR
GDYYCLPDGEKYLHCFKIKNSQNDVIGVIVMQYMELQHDDFEIISLFIRQFATELEGRLL
NEELARIAVTDSLTGLANRKAFDINLEEHIQLFNRYPERHFGLFILDVNGLKRANDCYGH
SMGDTLLIETSRLLVETCRLTDKVYRLGGDEFAIIVEAGNCDSCDVLWHRLEKVRAQINY
ACLPDGKRVEINFAIGYASTYQYSAEQISLVADKAMYKDKRYFYEKMGIKR
>A0A0T9M970|diguanylate cyclase|EC 2.7.7.65|Yersinia intermedia|TrEMBL
MLIAYLDALNILSTPVWLVLPKNQEILFANKEARAIAGDSPLQLLRNGRFSAHAQQHLDA
YLPALADEDQIVEIWTIQTEGNSFPLSCRLSLTQLEAYGDVIVFEGLYIAGAEVTRPNVG
RLCSKPYCRDERGFYEQFFDTNTAPMLLIDPSDDGQIVDANQAATRFYGYSRDEMCMKHT
WEINTMGKDVLPVMREVAKLPGGHKPLNFIHKLADGNTRHVQTYAGPVELDGMRLMLCII
HDITEQKRLEQALEDAALRDPLTGLGNRRQFFNLVEHANAQSQRYAQGFSLMLVDADHFK
QVNDQFGHHKGDEVLILLARTLESRIRESDMIFRWGGEEFAILLPSTNLAGALQVAESIR
EAVQLVCQPNLPQLTVSIGVAQHQVGEDSDSLFKRMDEALYRAKAAGRNRVLVA
>A0A450CGY8|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLGMTNIEIAKKLPDNIAK
FFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKPYIITMANDITK
LYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYEGHNVGDK
ILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQLETLRENFLKVFSKYKY
LSFSYGVDTVKRNLKLTIVELDKKMYKNKEKNKKKFDKNDY
>A0A0B7MEL2|diguanylate cyclase|EC 2.7.7.65|Syntrophaceticus schinkii|TrEMBL
MHFSSFFLLLFVLFKAVQTKEEGSHIIFAGTLILLITAFIDTTYANHFHNINLLSDTFPA
GLVVFVFLQAFTLSLKFSNALDISESLKTDLERQVKARTWELEEANRNLYMAVIKDPLTL
LYNRQEFENVVYAENIKYGERLQSHVKYSIICLDLDNFKYFNDNFGHSAGDIVLIEFAAI
LKKIIRSTDLAFRYGGDEFVILMPNTNVKKAISLAKRIVQETQTANKIFASKIEKSMGIK
VTLNDSNSITCSIGIAYHIPDTFFNLKNLFWKADKALLQAKKTGKNRIFVNTEQGLVEP
>A0A1V4SJ96|diguanylate cyclase|EC 2.7.7.65|Ruminiclostridium hungatei|TrEMBL
MLTFNYIEINMIAMAILLIIYFNIRNKKESYLYDQKLFILILFFNGLILVFDTATWTLNM
RSGEIPRLLNNISNTVYYILNPVPCMLWSVYADFQIFKDQNRIKKISRALSLPVIINGIL
ALLSPKHGFLFFIDSNNIYHRGSLFIFLCLICYFYFAYTMLKLVRKKNRMDKRQYVALVS
FAFPPFISAVFQILFFGISVIWICMAFSLLIVFINIQNNQLYTDYLTGLYNRRQLDNYLY
QKIKNRMHAKYLAGVMIDVNSFKQINDIYGHTSGDNALVCVSDILKRSFRKNDFIARYGG
DEFVIVVEIREQSELIGMINRLKENVEAFNDKKLIPYEISLSIGYDIYDTRSGVSIQKFY
KHIDQLMYEDKRGRAVS
>A0A450CA25|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MEEIDDTILDSMFKLTLNERLLTNNDFIENKIDVVKNLIDCYKTEQNSLMLLKSNFLLAL
LYGIQGFSEKMKEYILISCKYIDKCLSKDYKFLARFYSQIAILSLKNEDVNKANLYMDKF
NLICDENDFLIEEIIFKSQLIYIKASKCIESSVIIKEIETLYIKIKEINDFNCKKIYFFI
IGKIYFLFLNDALIAKVNFLKARKYADLLKDMQVSSLCNIKIGECECSFENYECSMEYFN
EVISNKKYRNVNIIQKYRASNNMTKILIKTRNYPVAINNLAKSEVYLEKIKNQGLKEVEK
FDLFISLAMYYAKSNEKSFEQSICYLDRAKNILNMIKNIEEYTIYDLEIIYHQAKIYYIF
GYYDNALNTNKKLLEKSKNAKNYNYVKLAYKNIYLCFEKIQNYEMSMKYFKMYYELKMMY
IKARNRNYIDSLNYRHEYIEKEINNMRKVKLDLDKKKYIDHLTSAYNRTFLNDFLEKQEV
SEYCTAFMIDVDYFKEYNDTYGHYNGDIALKDITIIIKKYLKKDMLMIRYGGEEFLILSV
CKDYKKSKIFGRKLCRIVKKFLNNNLTVSIGIDTCKNSSIDIREIIENADKALYKAKESG
RNRCLHYHDFKNF
>A0A0B7MI57|diguanylate cyclase|EC 2.7.7.65|Syntrophaceticus schinkii|TrEMBL
MKRSLKQTLTFWFMFFTFLPVVLFSYTACKYMIVAAEDTSYQILSRECQKESEYLSFWFR
EQMKDINFAIQLESDQQLSSDSLIRVMDLIEDCRRISLVGPDGVILADTSGETGKVVDLP
EGMPTERGVLRTNSANSLLVMMPAAAEQGNIICAEYDVNKIKLSTARDDVNSVFDNKLRG
QSKWTYSFGYNPRNPELSKIKFYVLGDCEQGAVALNKLTNSNSFSGQVSSRVMSWLQDRG
TGTETYADGDCQIIAAYRWLPDLEQLLVAEMNRNDVLSGIFAQWGSMVFLLLLVMVLISV
PMSTFVTRKLTNPLYQLIEEAQKIADGDFGYQIKVDSGLEVGVLTRAFNEMSLRLKDFYE
KLVLQIEILEEQKNEIKKRNQTLEVFRAQLEEKNARLQEIAYYDDLTGVMNRRSFLSSAC
EMFIEAQNLRLPIAAVMIDVDHFKKFNDNYGHNCGDLVLSDLADLLQAAVRKGDLVGRFG
GDEFALILQNTELEGALAIARRVQEATHKYSFEHPCEASEPSELRVSAGVCVWQPGHVQG
DVDKNLRVLLQKADEALLEAKRQGRDKIVACQAGLHFL
>A0A0F3N6E6|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum str. ApMUC09|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLTKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNVLQESF
QETTILSDPIQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSVLLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMYFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>A0A1V4SJD5|diguanylate cyclase|EC 2.7.7.65|Ruminiclostridium hungatei|TrEMBL
MQFLIHQQMNILSGAVIFLFGIYALSVLDKKAHINKIYIAALFLNLLLICFEIVLGMLRE
ARTGLIWVRVLSSLIFMLSPLLAYLFLKFICSYYLFPVKFKKQVRSLFILLLVSNVVVGV
FRFGSIKLEDENFFQCVIPFTIALVFLLYSLYVIILNRKMLMRFEYGYILAISMTTNIMM
TVQLALKQTSFVWCSSSFTIIMMFILIQQRELYRDALTGARNRRVLKKCWDDYTRKADGL
LSVVMIDLDYFKNINDSYGHSEGDHALKTFARLLHRVYSKEGTVIRLGGDEFLVLINNLP
EEKVNELISKMEKMVDKYNFNCSKPYLIKYSCASDAYNNDMGMEQFLHEIDVKMYNHKKS
RKRKYWSAENEF
>A0A381I7L2|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MSKETGYIRGCGYVATFASFFFYAIYSAFLSFKYRKAMHESKIWAIRGFLIVSIVAIILQ
AIFLQYLLTGTACACSLLLTYLSMQNRGLIIDDLTGVLNRQSFIQELDLNINTEQSGFII
TIALDDFKFMNETFGTKNGDIALKEVGKYLIQIHDVNHVYRIGGDIFSIVVNSQLGIEPD
DIIRKIEERFKKPWLVEEISFNLATSIAVVYYPENAETTEDVIVAIDFSIHEAKRSESKA
SCLCRCVYK
>A0A1V4SNR1|diguanylate cyclase|EC 2.7.7.65|Ruminiclostridium hungatei|TrEMBL
MLTSVIREFYSALITSLIICLVICRVNRDLKKVPLISYALSSLSIASIVTLINLLMPDLN
MGIKWICFSLVAVFVVMTFYRYNMYYTAISAVFSVLIVGLGSLLVALAYAYPLGLSMNQL
KDSFVHTTFLGLSEFVFSCAIMKLMADDFMKARKRIYKKHKKFMILLCGNLITAFVILLF
VFSLLNYAIEFRSAIEESRTVYVSAIFVVAVLISSIIGTIYLINYFLLNKIKYDRLKTNT
LKDLMTGTLNRGSGLKFIEEQIELCKTQKKSMTICYIDVNDLKVINDMLGHREGDFLIKT
ITGTIKKNIRETDVISRLGGDEFVIVFPGCTMEYSEKLMNRISGELRQLKPFTNKDYTIS
ISYGFSEYDGELEITVDGLLDEADRQMYQNKRAIKAMA
>A0A5I3IGW3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Nima|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6N3D0M6|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MFKEIFLRTFPGFLIIRDSNYRIIFINDNLKNLIKSYMQDNPLGMTNIEIAKKLPDNIAK
FFTDSHNIQLDWEKNYPYDKISNWILEFKKDTTSYWNVLEYKVDVDEKTYIITMANDITK
LYEENKRNLHYSITDPLTGAYNRKYLNDRFDIFIGDYIVLIDLDNFKMINDYEGHNVGDK
ILCDFVSLLNKELINSTSIIRLGGDEFIVIFSSDVDKNYVYSQLEALRENFLKVFSKYKY
LSFSYGVDTVKRNLKLTIVELDKKMYKNKKKFDKNDY
>A0A8J8BJM4|diguanylate cyclase|EC 2.7.7.65|Silanimonas sp|TrEMBL
MVWAISRAALWLLLLALTAGPLAALDPQRRFTDLALDQWTAADGLPQNAVLALGQDRHGY
LWVGTQAGVARFDGVRFERFDRRRTGGIDTAAPESHFRDSAGRVWFGTRNGALRLYGDAI
HRHAAAGTPQPVQAIAEWPAGRLLFGTPTGLLAKAPDGALLPAALPGFDITALLAADEGL
WVGTPGRLLRLDDHRQRSIELPGQPSPRIQHLLAEGRSLWIGTPTGLWRMEGEAAPQKLA
DTPGLAGQPISELCADAGGSLWVATPQRLFRRPPGGGFEPIADRDFVRNAWISACFEDRE
GHLWLGSHTEGLFRLWDGLITRITERDGLSEPFVWSLERAPDRAVLIGSNRGLFRWQADR
VERLVAPEALPDPAVYELARVGPAAVWVGTRGGLRAWQDGRLQRPAGAEALEGLQINTIV
EDHGSVWVGSSGGLFRAQAGGPLAAVASAELDGTLARVRALLPLDPDSVLVGTESGLRRL
DGEVLSKPVWARLLRERMVTSFLPLDDGRLLVAGLDAGIVVVASDRAVLLEPGLQLPEAS
LWAMRRIGDWIYVSSTEGLFRLPLAALPDPRTAAPAENLLAEWVVSMDGRSQSGQRARCC
NGGARSRMLLVDDQLWLPSISGVLKIDPEAASRTRVEPLVRIEAVQQGELRHFADAGEFV
LRGEHRDLRIDYTALYFRNPAALRFEYRLEGFDRDWIDAGVRRSAFYTNLPPGDFRFRVR
VLNGRGAPIEAESPMPIRVLPHWHERGDVRLLLGLLALGLVAAGVLLALRAQRRQTLRLQ
ALVAERTAQLQRVNTRLQQANESLAIESQTDPLTGLPNRRALFRQMPELLARHPEGVVLA
LIDLDHFKRVNDHFGHATGDVVLREFAGFLRRTIRDGDLVGRWGGEEFLVVFAGLSVAQT
PARLSRLLEDGNALVLEIEGQRLQPGFSVGWTCHPLGRTATSDWAHALELADAALYDAKH
RGRATWSGLVAGPAAAQLALEPNCGTKIETLVAEGRLAWVRPRRSAQTR
>A0A2Z4UNN9|diguanylate cyclase|EC 2.7.7.65|Rhodobiaceae bacterium|TrEMBL
MSGHDDFVFRDLFNHSFDAQWVLSADMHIEHANAAAVSLTGYEVEELVGQPLSLLLPPKI
AKSHDTYVAHYHKHGETQGVLGRPRRFEILARDGSLIPIQLKAFRLGGADDKRRFGATMV
DLRAQVLLEKEQLQTMAQLKRLALIDPLTELWNRRAFDDALDRQCALISRHHSAAALAMI
DIDHFKQVNDTYGHAAGDRVLQQLAAHLKKIVRKEDMCARLGGEEFGILMPACDLRSAAI
VIERALQRVATDRFDLDDGRTVSISFSAGIAAIETDAVADALVEHADAAMYQAKKNGRAR
VEMWVPETGAASASA
>A0A508TM28|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium ivorense|TrEMBL
MSFDTSTLYLFATMVAGMLGAMLLMFGRQESIPALKWWGTAYLLGAGAVAIWTLGGSSLG
VHIVLALNAVGFAACGLVWNAARIFHGRKPNLAGLVLGPIVWVATMTMVESPAMRMTIGA
GIVAVYAALTATELFSERRRAMQKRWLAIAVPVLHGGALMLPILVGDLLRPHDVNFVSSF
WVTLFSIELVLYAIGTVFVIFMMVSDRAVAVHKTAASIDPLSGMLNRRGFTEACTRVIER
EANAGRPVTVMIFDIDHFKSINDRFGHPAGDEVLKLFSAVVVNNLRISDLSGRIGGEEFA
ALLPCSLEEGVLVAERVREAFECSNITCEEGAVDTTVSIGVAGGPAGTELEVLLASADTA
LYQAKRGGRNRVEAAEELPLSLENWRRKTAGLPATARQKPAPVRA
>A0A7C8LU10|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MQRKDNVKIFGTAILCICMTLISISLVEVLIRRDTEHETALIHDTLLNTGALIGQEIQRN
LSYGIVVTETLHALLESNHYQVANFSKWGERLFALDSGASSIQLAPNGVVSYIYPLKGNE
RALGHDLLLDKRRDDGANLAIQSREITFVGPLKLIQNGKYAVIARKPVFRKVDGVDTFWG
FTIAILLVEDVLPDRVRQLEKQGLYITLEGENPDSQDPAVLFSSEKWVEGNDVAMTIEVP
NGTWTLKLGHDPITNKYYSLSRIFAAFFSITISIYIFVQQCMMSVKQEEISFLNERLMEL
SLKDELTGVGNRRAGMQALERGIQKSKYTKKTLSVLMLDIDLFKEVNDQHGHPAGDHLLK
HSVFCLNASAQRCNSVFRIGGDEFLMHLPEMGLDECMDVADAIQKFVEKMPCEYGGTELP
MSFSIGLAEHHPDETIDSLLHRVDIKLYEAKNAGRNMIKY
>A0A7C8HXR2|diguanylate cyclase|EC 2.7.7.65|Halodesulfovibrio sp. MK-HDV|TrEMBL
MLHSDNPSERICRFEVGHKYCDLFERLGVPRDDRWRSLLSCLRSTQKYSYYSQAQKKSVA
DLLIKTLENADFSEENYCSVLREYQAILASSYAKKLEEALKESADLADDFRRNVYTHKGA
VEGLEEQSVEAVRSGADPEDIVAQLRSTFQEVISVMKEDAERLDHICKTDGLTGLFNRRA
FDESLKGGISAWESNNTPLCLLLLDIDNLKNFNDRFGHRIGDQALQTFSQIMQEVAHRRH
DDEDICCCRFGGDEFAILLFGDAASDVIEIAQSIRARLETYDFVIRDNQGRIIKRNVQMT
VSCGFAYSRDFELENLAALMLDAADSALYEAKDLGRNRIVEYTKKDNSCTFTVISGGEVA
>A0A518KX35|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium TBK1r|TrEMBL
MTHPQTPFEPQSSTFNAAVPATRGVPNSSTVARGAANCVTNLLAKLQIASDAVSESPAER
PEKDAENRLAVVRLGIATSLFYALRTKHPATAAHGLRVALFCSSWAEQMGLDHDVRDRIE
VGALLHDVGKIGIPDRILRKPGKLTVDEQLVMDTCPDLGCDILQGCTTDPDLLDIIRYCN
LWYDSRRDGETPQGEALPLGARMLAIADAFDAMTTEHVYRPAMSRDRAIAELVRGSGTQF
DPDLVLDFSRLLESRPEILQGSMVHRWLQQLRPEDSQAFWTGTANPAVGKSHRTKEVVRR
ETLFNQRLLSTLKDGVAFTDGEGNVSQWNVAMERLTDLPAEAIIGKQWSAAALRMRDTDR
DRDDETICPLQECFRTGESVRRAMIIEAVGTDPVSVHVEVAPVHGERPGSHGTVIVVHDL
SDREHLERRLDTLHKQTRLDGLTRVANRAHFDTTLEEMVAATAAGGPTFALVICDLDHFK
RINDTFGHPAGDEALKVFANVLRSQSREGDLVARYGGEEFLLLANACDNATGAKRAEVVR
QTLESTPIEALGGECITASFGVTEYQSGDSAETVLARADRALLKAKDNGRNRVVQLGLGK
MSEVAEPAHRVGWFDWLIGGDEAVATKVDILTPVPVDLVIEKLRGFIADHHAEIVNVAEN
QLSLKVVSGSSPGGRRRIDHKISFHAVLTLSDAQKDELLTENATPGCSTKVHLELKPIRN
RDRRRRELNDAVQQLVASFRCYLMGEIINRGE
>A0A1Y6IUT0|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MPSMSVSPSWFRSLLPVLLIMAIHIGIGHEMITSLSNSSVLVNLPYVLFFTSLMIAQIFK
QSRMGMLAVAQLLAYAVIQFRLQTPLTSGSTLLELSLLALLFPISCVMSYVFRDSGLVTK
DFLYYLLAQGMFFLWSLLILDHFNQGNFPDIFTQLLSSVPQISRLPFILFLYLIVLSGIT
MLLLLRKNRKLDAVVYTSILLTSDVFVFFHIPHISSILFSISGIFLVLYVIAAGHELAFN
DRLTNIPGRAALDNAMKHLGRRFTIAMIDVDHFKQFNDNYGHDTGDDVLKLVASRLRQVK
GRAKVYRYGGEEFTVLFKGKTTEEAFDYLEALRQDIQDYDMHLRNTDKRPKNDKLGRMKR
QKNQANSTVNITVSIGVSDSQSSRDPQEVIKYADQALYKAKKTGRNRVSAMNVVDK
>A0A0T9RHB4|diguanylate cyclase|EC 2.7.7.65|Yersinia massiliensis|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVSAVLYTQNSPLWLWIMLALNGLVWP
HVAFLLASRSEEPFEQEILNMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFSPETSPLQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQEKLADLVF
EQAPPLQLRVSAGIAEYKQDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A1Y6IR90|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MDNLTLLETLVIIMSINVIFTFITSARVNRTVSIGWRISSVMVFTGCALLVMQQLLSSFF
SIILSNYILLLGFYFQIYTSILIDFGYNVLKKKFIFFISLVYAASFLYFTYVDFNTTARI
ISISSILLGLYLYAIIILYKKNSIKIKELYYAYIFASVFYVYRILSTFDGVGDVSSLFDK
NIVTTLSFLFLIVFNLFYLIGVFNCINREKENELLLEKNKFKYFLDFINDAAKNLELSEL
YPAIEKVLRLSFGVGTAAIFLRNEGESEYSHSVVYDFNDLELPIQKLSKTIKLGEGMSGK
AVQKDKVLRIDIEQYPNREIAIECQLKGATQMVAIPLKISGDIIGAITMIYSNGHQRVYT
LDNKFCYTLGEQIALLIQNALNYKKIQSLANSDPMTHLFNRRKGVEIFSLELKRLSRNDN
KLTVAMLDLDNFKKINDTFGHECGDSVIKNAANMFKEICRETDYIFRWGGEEFLILFIDT
DISGAYSIAEHMRSRIERNSIPCIDSFPSTISIGLAETSGDETMDQVLSRADKALYSAKD
KGRNRVEASY
>A0A841Q498|diguanylate cyclase|EC 2.7.7.65|Salirhabdus euzebyi|TrEMBL
MHEIIDAFVANMTLIIAFMYVVLKFKELILKKFKKIPMYIVITPVIISLLSMWVMHHPLM
FEGMRVDLRGIPIFFVSFLGGWKMGFISILFPTWMRIDLGGPTVIQGTIQAILLPFIVGS
IFHNRKAFNPPYTILNVKVLLTGFFTYAIIKSVLMLWTTPANEVTTILMFIFEIAALLII
GLINNDTNRNLLNRNELEFHSRHDNMTQLYNLRYFKNKVNDLKIHDKSMVIAMFDVDSFK
NYNDTHGHPAGDAVLRTIGQLLTDSMRKEDLFARYGGEEFIICFSNLENTQAVAKAAERF
RILVETYPFYGEEKQPNGKLTISLGLSTFSHTKALDTLIKEADQALYMAKEAGRNNVKLY
SKDAD
>A0A379SQR9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MKDNSACSSSALLFLDGDNFKYINDTWGHAAGDRVLIEVAKRLAEFAGNRYQTYRLGGDE
FAMVLYGVHSEYEVQRICAALSPPV
>A0A7W6M8F5|diguanylate cyclase|EC 2.7.7.65|Sulfitobacter noctilucicola|TrEMBL
MQGKILVVDAIATNRILLKVKLKKAYYDVIQAASMEEALDLVQSELPDLVICALSLPDGG
ATELCQKLSLGSPIGHVPVIAIGCQVGPEGRMATLEAGVHDVLRQPVDETLLMGRVRSLI
RAHNATAEWQMRDDTCRALGLAEAASGFEEQGHCVLVNDDRCVLQKYATQMRPMTRAKLT
LTCAAALMREVVLEKVPEVFVLILPQDHNAAMEDLRLISALRANARARHTGIIVLQRNVN
PELGAHALDLGADDLMTDGFDAAELALRIKSVLRRKRMGDQLRATVRTGLQAAVFDPLTG
LYNRRYAMPHLDRISEHACTTGRKFAVMLGDLDHFKQINDAYGHASGDAVLVEVAHRLRQ
ALRGTDMVSRIGGEEFLIIMPGTDLPQAQTAAVRICDDISGAPFIVPGNVQPIHVTISIG
MTIGGADAGMGKDGVANSPKETGHSLLEEADSALYAAKGRGRNQVKLSRPAA
>A0A2J4RJC7|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVRAVLKNIAGQQAEALATRFYDFIFQDPDIARHL
SYDLVQERLSSSLAGWVKDILMCDKENLQALAERQYLIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSQLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQASLSGWENTAIFNIVSDNKSDINGALL
>A0A2X4TVZ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MCGTSANSAIAALSRVHERLNTLRLPGAPQVMLRISVGVAPLTSQIGHYRGWLKSADMAL
YKAKNAGRNRTEVAA
>A0A5U3DKP8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MFPKIMNDENFYRKAVERAVAPPASQNEQQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVGGGWWLLLVGWTFVWPHLAWQLAAKARDPLSREIYNLKADAILAGMWIALMGVNLL
PAAALLMMMCMNLMGAGGPRLFFAGMALLWASCLVTLQLTGLPVATRSSSLEVTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRQHWEILLRDEFDHCRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVVLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1Z5I2R5|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MNDSSVAKKQLVALKRKLDSAIESRNSLEEDANLHSSLLIQFITKLSLVSKGIDLELDNR
LAQLRMLFSKSAPLNDIEAKIVVISKLLQQHSITNEKNIAHLHDQFNQAGENLQKINGLP
GDLRRELRGLLSKTKESKDALIQYVPLLSQLLAFYDYALKAKNAPTKQGVLPSAQLILPV
SQSKNDINLALFDSSILEKISVSLSTLPLSKGHTNELLAIKKKLMTDKSSDEVLLHLIDI
FDVIVADFKDEQNSAKNFLTRLSATLTTVQSAVKETIVTQKKSQKTNEKINQKLQSQLVD
MTGTVEKALSLNQVKEDINEKLQFIASTLEQKSKFEQQSHQELADKLNDMSAKVDQLEQQ
SRVFEHKLIDQQRKSMQDALTKLANRAAFDNYFAKAMVRFHHKPFQLALVVLDIDDFKKI
NDTYGHTAGDKTLQVIANTIVKNVSKGVFVGRYGGEEFVLIYSQAQEQALTLELNALNKY
IARLPFKFKSNKVSITLSIGATHIRADDNIHIAFERADQAMYKAKKQGKNQVIYVK
>A0A162RAM9|diguanylate cyclase|EC 2.7.7.65|Clostridium magnum DSM 2767|TrEMBL
MQKILNIVDKNFIKVDILNGIRKIQNVFYEKNIECFAAYENKRLVGIVTKRELVAAHSNR
IIADVMSDKYMCVNCYTHIWNIKELFDSDKNIDVIFVEDENDIIGFITRTTLNIELSKHI
DSLTGLYKSNYIYCNSYNLIKSGQNTTVVFIDLNNFGYIDKTYGHVNGDIILQNVAKVLK
DNTDSHSYLCRYGGDEFAILTSCCIEDSKRTAEKIINAINSYEFPNGIPISAAIGIASYK
LNNNNNKISDIGDAINRLVNAASLASTKAKRDGNNSIIIENVDIDAIA
>A0A8F7YIX2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1Z5I0J6|diguanylate cyclase|EC 2.7.7.65|Colwellia marinimaniae|TrEMBL
MTLEKSQLHELHWIMEMLHNIDVGLVVLDKEFTIQIFNGFMENHSGLFPREVKGKLIFDL
FPEIPREWFTRKAESVFLLKNKAFTIWEQRPYLFKFDSYRPVTGSEELMYQNTTFIPLLS
ATGEVSHLCLIVYDVTDTAVHKLSLKKANAELALLSQTDGLTQLFNRSHWEQCLLAEHKR
WSRSQNPSSLVMIDIDHFKNINDSYGHVVGDKVIRHISGLIRHHVRETDVCGRYGGEEFA
ILLSDTNLENAFIFAERLRKEVSEAIVTYNDINVKYTISMGIAEVDESIETHEVWIECAD
AALYRSKETGRNKTSLHPKQTK
>A0A143QBX4|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. PBTS 1|TrEMBL
MSALRDWWSATPDYDWIRDYHRAHPLLRRAPYVTAAGCFLVAIIAVVLVFSPVANGATVQ
LLIAAASAVGAGCWWARGTFPSRRGSLAFIAYAGITIPVGILSTPPSTLSLYAVAIMVTV
GNYVTAMHDARVFVAQEAWSLLVAVVVFARVLSAGVAPAPEVIATFVLVLGLLFTASTLN
HVFLTALRNDASRALFDQLTGLRNRRGMHTAVAALMRDHRPDHLSVLCLDLDAFKSVNDR
FGHAVGDEVLRATAARIEELSPPGAVSARLGGEEFAVVVPGDDARAFARSLVTEIHRAND
RTPVTASVGVAVEDVADWDGLCPTMLGRLLDRADLAMYRAKRDGGNNVVVDGTGATDGPL
>A0A127MXM1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MGAVVGKGLSFARRIYVPRMVGLGIGFFCVAAALEPLQRPGWAWALLVANGFLWPHLAYQ
LARLSRAPYQAERRNLLLDSLFGGFWAGAMQLNPLPSVTILSMMAMDNIAAGGLRFFLLG
SVAQLLGVLLAWLCFGIAFTAVATPLQVYACLPMLVVYPLAVGGVSYSLARRLSEHKQAL
RAVSRTDSLTGLLNHGSWMDQLENEFQKCRQQHTRASVALIDIDHFKGINDRFGHVLGDM
VITELSHLLTHSLRETDTPGRYGGDEFCVILPGTTQTLAVEIMERLRQSFAEKHYQLATD
LSVGLSIGVASYSPYQVDASAWLSDADKALYRAKHQGRNQVVGAGPQPQ
>A0A127N1A3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MDEQQALAGDREAIEKTLRYALEIVSDGIWDWDIRSNDVKRSPGWYRMLGYPIDGLPENV
ATWHSVIHPDDFPRVMRSFQAYLDGRQAAYAEEYRCLCANGEYLWIRDHGRFVEFDDQGR
ATRMIGAHHNIHERKLIELELKRRNEELHELNRNLEQLVEQRTEALRQANLALAEQAAVA
VRLSETDPLTQIYNRRRFESSLQQEWQRLQRHDQPVSLLMFDLDHFKRINDLFGHPVGDR
VLVAVTQAVRRTLREEDCFARWGGEEFIVLLPNTPLASASRLAERLRLHIREACAELEQP
LTASFALAGMRRAEPLENLLRRLDDALYRAKRLRDAIEVC
>A0A379N376|diguanylate cyclase|EC 2.7.7.65|Roseomonas mucosa|TrEMBL
MLPHLMPLSEEDRLAALRSYDVLDTACEASFDNIARLAADLTESPISMVSLVDAERAWFK
AHHGLEAPEAPREHAFCAHAILEPGTPLVIPDASRDPRFAGNPLVTGAPDIRFYAGVPLV
NPEGAVLGTLCVLDRKPRRMSAERQRILVRLAEAVMTTLELRRAMNRVHRLSMTDALTGL
LNRPALMDALDKAVARLNRHGEGFALLYLDLDGFKQVNDREGHATGDEVLRELAAVLWDN
LRREDMAARLGGDEFAVLLTGREPDAAIVAERLQRMLEAAMRAKGWAVTASIGAVSFHNA
PESVDAALSLADSLMYGAKAAGRNRVLHRDH
>A0A2N7RTU4|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MALDPSTILILTTALAAAAALYLAVEWRSVREKSLLFWSAGFAVITVGCVLALLRTSGFL
LIGIWFANGLLIAAHWLFLAGVARFMDMRLSRAWYLLPLAWLAMLLVPGAPWWSKVMFVV
QSLLIAGICLRASYLLRPHGVSLSVGAVQLRYVLLLHGLFYFAKAASIVALNTFVDLAGF
RGEVIQISLVEGAMAIMLIALSMTGTERHRREERIEQLAARDPLTALYNRRALDERAPAL
LEQASPHSPGALLLIDIDNFKQVNDLHGHSAGDKLLVALSEMLCNTLPQRALAARLGGDE
FVILLHGASSDSVVALGNALRGMFGQMAQQAFATPKAVTLSVGATLFERPPASLAALLEL
GDAALYSSKREGRDSVRVVRAA
>A0A1V6A6C7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin153|TrEMBL
MFTALQVSINLFSLAILLMILFDLKYQDELHSPNQFNYIELVHSLMAVLILEALTWAVDR
RQGTAFRIANIYANTAYFMADVFPAFFWAIYVTYNIYGRTRAYKRLSWLLFFPALINACL
CASNLYNGWMFSVSADNIYRRGDRFYLLVLILLFYIGYSNILIFINKRRLTKRAYHTLLL
FSIPPIIGGGLQFMFYGMPSMWSGATLMLLMIYLNIQRIKLGADPLTGISNRRDIGSYIK
DRIKESSSGASFSGIFIDIDNFKSINDAHGHVMGDKALQLTADLLRKSTRKDDFIARYGG
DEFLIILPKLEDHAALDKTVSRIRSEFDGWNRLGILPFDICLSIGHSVYEKGSGNSAEQF
IRHLDSLMYKSRS
>A0A6N1MJ51|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDE
LIQQRLRDTLNAWLLESFSVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENPHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQQIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A543Q7W6|diguanylate cyclase|EC 2.7.7.65|Acidithiobacillus thiooxidans ATCC 19377|TrEMBL
MTARSQTETYAYQNNASQVDSGPYLADLVNFYEAWKSFWQLWLREHLQGRPLPRPAEQGV
LQSIHTPESRVPEARRVFWQELQKSYHNILQKLQDLNLNEEPANDLFAVMNAAEALERQC
FDEIMAFSRNLGEVDPLTGLLNRRRMEDDLCREQALVDRGASAFIAMLDVDHFKTFNDRF
GHVNGDLVLKELSRRLHSALRPYDGLYRYGGEEFMAIFPQMHKSCALLTAQRLCQKIASA
PFPLEQHTPVQVTISIGITPLLPNVPSHERVVIADAALYQAKHEGRNQARLLP
>A0A554WT79|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MTSELDLRAVVLLLGAIGVLTSVVLLHLWRQNRELLPAAAWWAAGPLVIFVGTVLMGLRG
WISPPVSIVLGNGCIVGGAALMYMGSCRFWDERLPRWPWVWLGVTAVALLLLSTVWPHYP
LRLMIVPGLMAVVQLAHLQLVWRHDRSSFAARFLLGWIAFSAVALAFRSATAQLEARDAD
LFTPSVWQNIYLGSYAFSLLGEGIGLVLLAQQRLQQHIRDLATHDSLTGALTRAAFWDAA
THELRRQQRSMRPAALLMLDLDHFKRVNDTHGHPTGDRVLRDFAQRVRRTLRATDRFGRY
GGEEFVVLLPDTEATAALAIAERIRAQPCAADVPAYTVSIGLTAVAPAGADAPPGVTLEA
AIALADAALYEAKARGRDRVVQAPTGTAA
>A0A5C6AUA0|diguanylate cyclase|EC 2.7.7.65|Stieleria varia|TrEMBL
MIDSNAPMGPIPTATPESNLFVDAEAGHQHVHSLLAQLQDDSHGPSQSRAGQSEAKVENQ
LAVVRLGMATSLFYSLRTKHPATAAHSLRVALFCSGWAERLGLAGDQRDRIEVAALLHDI
GKIGIPDRVLRKPGKLTVDEQLMMDLCPEMGCQILAGCTSDQELLDIIRYGNTWYESRRH
GEGPRGDALPLGSRMLAIVNAFDAMTTEHVYRPALSRDRAIVELVRGSGGQFDARLVADF
GRMLEDHPEMLQGVVVNRWLQQLRPGTSQGFWTGNADRTDSSSKSGQGTVLRRETHFNKQ
LLHTLKDGVAFTDAEGNVTEWNDALASMTGVSADAMLGRQWSISAIGLRDADRDEDTEQL
CPLKQCFQSSGSVKRPMLIEQPGEEIIPVHVEVSPVRGDVPGTLGTVIVVHDLSDREHLQ
KRLESLDQQTKTDGLTNVANRAHFDATLDELTAITSAGGPTFSLVICDIDHFKRINDVHG
HPAGDEALKTFASVLASHSRDGDLVARYGGEEFCLLAANCDNSTAAKRAEALRIALEHMP
IPSLGGEQLTASFGVTEFQSGDSPETVLARADRALLKAKDNGRNRVVQLGLGKMSEISDD
DSSKHSWLSWFTGGAKNSIDQVDILTPVPIDLAIEKLRGFIADHDAEIINVSENQLSLKL
TATCTIGGRRRIDSQIAMHVKLTLSNPQPEEQLLKKMQPGTNTKVHVEMKPIRNRDRRRR
ELEACSQQVVASLRSYLMGEVLRRSQSTDLT
>A0A1V5JVK8|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin510|TrEMBL
MSAAFPASARRQAGLSLLIGLLLVMLALALWWGLSLREQARLKDLLANEAAFLTAAIEAE
VRGSLPTFQRMALRWERGSGTPAAEFAADAADHLADMPGIQAIEWVDRDYVVRWVVPLKG
NENVRGRRLVHSEARRKAVNQAVRTMKPAMSSPVELVQGGLGLLVYFPLRAAGQFDGFIV
AVVRLEPFLASALSHDRHHDLKRYFQLEVLIDGQRVIQQPGWVDSPYGNFQTEAATTIMG
HEFSVRLRPTAAFIAAHASRLPEFMVLAGLTLSLLLSLIVHLLQKSLSEARSLSRAKLAL
ENSIAERHQTEQQLAATLARMDLATRAGGIGLWTWDIASGSLSWNEQMYALFGLPTDLQP
TYDTWRAAVHPDDLAATEDLLQRASRGQAIFNDEFRIRRPDGTLRYLTAAARMERDGSGR
PIRMNGINWDITEWRLTEQALKESEEKFRVLTESSPTAVMMYQDDRWIYANPAAEALTGY
SRAELRDQFFWEFIAPEDQPRIREIGAQRQSGQSTLNNYDIRIVTKNGEIKWVNITGATA
HPGGRPAGILSIIDMTPRRAAEQALRSSEEQVRLLLNSTGEAIYGIDLQGCCTFANPACL
RLTGYSDIQQLLGRNMHDLIHHSFADGSPMPVEVCRIFKAYREGARMHVDDEVLWRADGS
SFPAEYWSYPQLRDGQVVGAVVTFIDISERRATEAALVRERQRLGYILEGTNVGTWEWNV
QTGETVFNLFSGRRRSVSAAVNKVTRSATVKHDIEAAEEQVEAVQADLVNLQEELKAQTE
AITANWEKALGDLEEVAIKPRRTDIQIALFALAWAPHWQIVYQEGAVTQTQTVPAF
>A0A6N3A4T2|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSVITYLQRLANGVSTAELDVAALPTELHAIGEQLQKTHAILQQERQLLER
NVHIDPLTNLGNRGGLDRHVEQLWRTGDPFTCAYIDIDHLKHCNDKFGHAEGNRYILSIC
RALTETMEHDEMLFRIGGDEFVLVSPTTGEAELEQRLERVRADLIEATSDDKAPMISSFS
FGCSRVDPLAGDTRRQMTMDADRKMYRYKLMHRVQQPKDSDAPQQPIAEQFPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSVDMWLARVHPEDRDNVRAEL
DMVVNGTWHFHYMQYRVMDATGAYALCDCTGYRLDGTDTEPNMYVGIIVNRSLADTTDSV
TGLGDIHALVNAIAEMRRVARKAGFIAIKVDDIAEVNARFGFDAGDRVLAESAACIMDCS
RGKGRLFRSTGPMFVALFDELGPEAIDELASEIERFLGSPVLIGSLEYQPPIRVATLHLD
GVDRQPVSILNELKARLKEAPQVPGTKLD
>A0A173YYM3|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNTSVAKKAGQAVRLLMMVLTAVLIFFFINVMLLVSDIQGTARVVNYAGLVRGTTQRIVK
LEDAGQPQDDLLKAVDSYINGLRYGSDDLNLVRLDDDEYQAKMTELASYFDELRTEITRV
REVGYENTDIISMSEEFFGICDDATRLAEDYSQEKASALNYLEGLVIIDIVGLVATFAVE
LVRAVRTAALNRELHNKVYLDEATGLPNKNKCEEVLGQEQPVSAEAPVAVCVFDLNNLHT
VNNNFGHEKGDEYIRSFAQQLGCVASETCFVGRDGGDEFIAVLWDADRAAVESCLTRVRA
NVNEYSEAHPDMPISYAVGYALSSDFDEPPMMRELFSQADKNMYIDKNRVKTAEAAGPQR
EDR
>A0A380ST46|diguanylate cyclase|EC 2.7.7.65|Pseudomonas wadenswilerensis|TrEMBL
MFRLSAVRLSHFLPSVCLLVSGLAAAYVRDLSVFFTSLFNVLPTLVLLLGGAYCAVYRRQ
RELFLMLTVYIAYFLLDTQTDFYRDNGRVREDAAVVFHLVCLLLPLMFALYGAWQERTHL
FQDMVARFAVLLAVGSVALGLEQSFPQALLSWLAEIRWPSLHGQWMSLIQLAYPVFLCAF
ILLVVQYLREPRPLHAAQVIGLIGIFWMLPKTFILPFTLNIMCSQVMLMIAAAVSHEAYQ
MAFRDELTGLPGRRALNERMQRLGRNYVLAMTDVDHFKKFNDTHGHDVGDQVLRLVASKL
SKVTGGGRAYRYGGEEFAVVFAGKTIEECMPHLEAVREVIANYNIQLRNQDNRPQDDQQG
RQRRGASAASSVSVTISIGASERLADHRSPDEVLKSADQALYSAKGAGRNCVMAHGVQAK
RGAVRMA
>A0A1C6AJV2|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNFEEIIKDLEKLEADKEYIKIICSNINGLEYKASREIYEKLIEYVKERNLSYAYPWIIH
NYGWIQHGLGNFNKAIEVHTEAYNIFKREKDNDGILTTINALVGNYSFIQQFDRAIEYGI
KGIELAEKVGNYQVLNSIKNNMSITYVEIGEFEKAKSILEQISNLPDIDVKHNKIVNLIN
LAECERELNNHDISIEYLENALELSKDFALNLIPGVLEEMGRTYCAKGLYNIADELFSES
VRISRDTEHKLCLNEALLYWSEVDLKKERYNNAIAKLKEVEGNIESVNSIRNKNKIYSNM
SLSYKALGDYENAYLYLEKVNHIQREMFKKTSVESIKNLDKKRLEDEETVYKSLYKQTEA
LYSVGQRITANLNRKNIYKVIAEEMKNLIKCDVLQISLINVENKTLEYKLCMNLEKDFDM
VPTNLNDENRFGVYAIKHKQEILINDLNKEYYKYFNNFESYIDKLSKEQNRTSERFSQSM
IFVPIMIHAKVIGVMSVQSYEKSMFTLKDVNTLKILSTYVGIALENSKLYKELKYRANYD
VLTKIFNRREVLRKSEKIYNKVKKDLESYCVMMIDVDNFKKINDTYGHQIGDKVLATVAN
VIKESIREEDIAGRYGGEEFIVIVKDDYNSNFKIAERIRKNVEKIAINIDDNRFIKVTSS
IGITKMDAKDKTLQQIISDSDKALYEAKNTGKNKVVFYC
>A0A1C6FPB3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MYKRKNTNNVKVKMNEKVIIAIVFICFILTLTFSVISFYKSKQNQVGIIEKSLEDNGNQC
KESIEEYFEYSFKILNYLANNENIYNMNWDEQYSFLKGQETLLNFEHFIIMDMLGNGYYV
NRNEVKDQSHEDFFHDVIDNERFVTEPFMEVHKNRSITTLSVSIYKGKKKVGALCGVIDL
NKIYNIFKNKVVGKSGYSFLINNNGDYVAHKDMQFVHDSKNIFEDFEGKSNNIDFLREGI
NKGETSLGKVKLNGETYYANFNPLDSVKWNAVFLIPKDEVLSGFNKFVIFQLLALTSGFL
LIIFGVRIIYKNIENHRLAYTDGLTNTNNRAAVDIKFKELDNKYKSNITIVSFDLNNFKY
VNDNFGHHIGDELLIKFAGILQETLGSIGFVGRMGGDEFIAILNNIDIEVIKSKIDDMKE
KIEDYNYNKICKLEISYGYFNRGNGDKRPLIEIYKEADKKMYVFKKQIKSI
>A0A1C5L7B0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDNDNYKIYTKDVLNLIFSNQDIDQLIPYLSKNVKAMGLYTEDVLKYNDIINHIKTYKSN
HFTFYIDQFTCTVIYQNNSVCITEGVFYLNMEEYQTRTKYFYTIVFKDHQIELLHTSIGN
TPKDLKEAPFILASCSFKLDEQLSIVDINDNLLELLLYDNKEEFLNDIDYHWINCIHKND
IFNVIKALSENVSALERHHLEYRIKRKDDSYLWIYDQGHFIFNNQKNLIVQCYLSDISPI
KNRELASSVEKEKYQMALKDNSISILEYHIQDDRMIIDILEQSKKQIYDHYLDYVSSSKS
TVFEEDKQKIVDLFTQKIKGPIIYRKYYRGSQEYCVKTLDATVIYNSNDEAEIILATASD
ITVNWHEQNSLKQQAQRDSLTHLYNLEAGKYIIDEYIKKNPKQQNALIVLDIDHFKEVND
TYGHLVGNELLIALAKYLLFHTNPNDIVIRMGGDEFVVFLKNVHDDLTYPCNQLMSHLNE
ISLSHHGIHFSISMGVYTFSNEQNFDTIFKIADDALYHSKRNGRNRYTIKYQK
>A0A1C5W1K5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLKKYFEDESYNIMPCGVVAFQNDSTLKIISANDYYYSTYANGNFESLNICEEDKNIIAD
LKDKNEVVYKCIVSDGTIRYICMHLTKYNENDILGILMDVTEQHTNLVRMKDERRCFTFA
LKSSKNIVFEHNVADDNMTLYIPVKGQTELKKLSIPNNTEDAVYELADKRDYGYLKENIY
NEKVENISVRMKLPGNKNYEWHRIFRNFEHDEKGNLKRIFGTITNIEDEKHHEKELKEKI
EIDPVLHVYNRNAGVERINEYIKSNPESRDYALFVIDIDDFKNINDTYGHLYGDTVIAMV
AEMLNKATDDDAIVGRYGGDEFFVLLKSSRIAENADRVVDNVCKINISDDKRITCSVGVA
DGRIFEEVPDYKALFSKADKALYSTKKNGKAHWEIYNENIVYDNSSHAIDYEVEDAENST
ELFKTRDMMKVFLELSSSAKNSDDAMYKIIRYVAEKFGIDWFQIMKVNIKEDLITISYEW
CSDPKFQNNAGKRGYYAHSDIKHFKEFFEKYPVFILSNEKINGFSLKFQREFEKNKKNGE
VVYNANITTGDSFFMFVCTRFGYENPWQIEECVELNMATKLMTMYISQSDKETENEKKLR
KIIDYDRKTSCYTIAKFYEQIGRLRKFAEEKDEQVALLHTDFSGILDFNERFGQIEGDKV
FTEFVNCILPSDNDYNIITHIDGADIFFSAFRFKNSESFDKIDALNKQFSKMINEKYPGA
HIIVKTGIYVLKTNEVVGVGLDKALKAKKTVKNPTESFCIVYDKDKHENSRC
>A0A1C5UN95|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MIDKDQELFLDYIKQLLYNTDEATLCRDELSDDVTQLADGIEYLGEVIKDEKIVLSKMAQ
GEVDEEFSISHNYLSAPVKSIQSNLKHLSWVAQRVAAGDYKQHVSSLGSFSDSFNEMIDQ
LSHYREKMEHISNTDVLTGTANRRAFNQMIKKLWDKDIPCAIVFIDIDGLKYVNDNYGHS
GGNRYIKEVCQILKMNLKEDEFIFRIGGDELLILSKKEDAHICEERLLEIRLQFREEMKK
KVPYPCDFSFGCVDIDKKENKTISEYLSLADKKMYHFKMQHYIDQRRPKYSNHIDKSGLD
SRIFDAFSQTSINRYAYICNMETNVSRWSVQAVKDFDLPYEYMYDAGKIWEEHIHPDDCK
EYEEDIEAVFSGKKECHDLTYRARLKNGKYIKCRCEGYVLRGRTAKELNLFAGILTRVDE
AVNYEER
>A0A1C5R666|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MGYHSIPYDRRIRENIKNYSFSHLYDMDTVREYLQSLADVLEINILLTARHGEKEIVIGD
SFLGFYPDVVNDPGRKIRVQNRTIGHLYIKEIVSAENSGQISDMVDSTVALLEELGEEAY
KRRETSIYLEELERLLKERRRQISQNETDDPLTGVYHRNYFLTRMEAIDRSEAVPIAVLN
VNINDWKFVNDHFGDEESDRLIQTVAAILKNQAGPDYIIGRIDGDAFGVLIPMATEEEAE
SYMEAVQRACDTYEDRILAPSVAIGYVIKTNIEEKLEDRLSDAEYEMFNNKFEVKNAKGY
QERLRKGLKQAK
>A0A6N3AIR0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MLKDENTRLRVLAEHDWLTGLYNRRAAEAHVDEALLKNGGGMLLVLDIDHFKQVNDRYGH
LIGDALLCEAARTLRDIFFPRDIIGRVGGDEFIIYILGGCSQEAVDGRAAQLAERLRKAG
RRYGMQWNLSFTLGLAEKQAGDDYISLFDRADQMLLARKKARRARRADSADAGGERSICT
DMALIRRELREKDPPKGAFCQDYETFKQIYRFVERGLKRSGQSAYIILMTLTDAQGQFVP
LAAREEYMSRLSDDLQASLRSGDLFAPYSGCQYLLMVLGASSENAAVIAGRIHTRFMSRV
APDAGLLLRYDVYPMGELPLQPKG
>A0A1C5L1Q3|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MHLMAEATGVNMDTCPEQVKKVELSDDDRALSDTEKISKAQMLVSGRQYQKSKLEITNCI
TAGTDIMTEQTKNRQSHAEDKVEDMYWKLGIGIACLVLLMIEMCYMVRRLIVKPLVNYNE
CIREGAIFPIVGAEELQNLAKTYNQVYEENLETQRLIRHEAEYDALTDLMNRGSFDRVLQ
IYKNGDTHYALILVDVDIFKSVNDTYGHAVGDQILKKVAKLLKQMFRSIDFVCRIGGDEF
AIVMVEMTSDLGYTIEEKIQAINEELTSADDGLPKVSVSVGVAFSDRDNPGEDIFQDADK
ALYRTKENGKCGCSIY
>A0A1C6IRM7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MSFFLYNFLQGLLHKSEGSFLDSIKYFKRAEIHLSRIEGSLKCLYPKFSHEYCSLLISLG
YTDDANKIKTNAIDFCIKNNYSFYLNLLSNNTTPNIFFKNSTTHLQWVIEAARQQANIDN
LNSKISEINFLNLFQENLSSSDNIKTVKKLSIQLIENRFALDHTILISLDDYDDICIELS
EEITISKEELNQLKNSFNKINNSFISSRKDSNCPILDKIGTILNLEIYSLVYLPVIKENK
TKCFFLGITKISKDILSSEIIINSDNIRILNIAIKQLFETTQRIKGQEKLLSSANTDVLT
GLYNRQGFFNNISSVLSNNKSNFSLQHHFLIYLDLDNFKFYNDTFGHKIGDTVLKLFSNI
LKSKITSYDMAIRYGGDEFILFLNNSSKENCTTLIEGIYEELHLKSGFKSEISSLLDRNV
YIPKDKLLSFSTGIISLSSKNKFNISELVDNADKAMYKAKKNGKSCYIFA
>A0A3R0XFX0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWISLPI
IVIYPLLFGWVSYQTAIKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A2K9LE80|diguanylate cyclase|EC 2.7.7.65|Rhodocyclaceae bacterium|TrEMBL
MAFLSGLVMNHSNTLEADWLELFDNVPEATRGVLREVVRAHKESMADAFYARMLGDPVAH
PFLTHEAVETRLRHSMQRWLETLFSCTDRAQFAVAMAIQRHVGEVHARIDLPVNIVARGA
RVLKAEIARHLLAAGLSGQALIDAVLYADNLMDLAFEEMSAAYVASHEHVARIDEAYRAF
SFGQNLSLERERQRAALLDWENRFLHDMMTGSAGDPLPRLTESAFGLWLHHKATAIFEGA
PELPAIRQAIRTIDDDLIPQCQAKLGGPERDTQRRLTKAVLSELGQLKFLLGTLFERFVE
LESGKDALTQLLNRRFLPAILSREADISRRQHKPFALLLLDVDHFKHINDQHGHEAGDRV
LQHIASLILATVRAGDFVFRYGGEEFLALLVEVDLTHALRIAEKLRSRIESENVLLPNGA
SLKLTASIGVAVHDGHPDYQRLINRADEALYRAKQQGRNRCVVSDA
>A0A0E1C156|diguanylate cyclase|EC 2.7.7.65|Borrelia hermsii MTW|TrEMBL
MMKGVILDNFEEISVESQKLLLVDDTPTNLDLLIDILQYNYEIRVAINGFDALKQVEIAN
PDLILLDVLLPDISGYEVCKRLKNDPETRDIPVIFISSRDSTDAQLEGFNVGGVDYILKP
FNGRIIDARIKTHLELKRLRDYFKNLARIDGLTQIPNRRFFTDKFAKSWMQALEHKRNVI
VGMLDIDYFKKYNDNYGHTNGDECLKLIARSLNKIAIKYNIDIARYGGEEFILFSVNKSL
EEMIDIVSILIEDIRNLELIHEHSSVSNFVTVSVGLADQIPHDSNFTNIIKLADDKLYEA
KISGRNQFKY
>A0A378GIA8|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MLFRIIVVMKKEKQYIPIVLTSPFRTAQLLFSLGLLTFLFTLYSFALMHHPSDLSPVWLP
TAVMMAGFYRFKRSLWPGIALAGALGVIAATSLYSPSAVTLTYPAINILEALVGALLLRR
WLVLDNPLQNLVDWTRMAIACALVPALLGGILVASLYPGTNALQTLIVWAIAEATGALAL
VPIGLLLKARFATRYQNTSLLFSTLLTTVITLALSITAMLYLPWPFTFIMVLLMWSAVRL
PRLEAFIISLLTIMVVLMLTSLHPLVQHMIENTLNSYRLHNMPGLPFLMVLLPTGVMSIA
MYAVHNERRHIAESETRFRNAMEYSAIGMGLVDTYGQWMQVNKALSAFLGYSQEELHRMT
FQQVTWPEDLATDLEQLDRLNRGEIDSYSLEKRYCTKHGDVVWALLAVSLVRNNDGTPLY
FIKQVEDINSLKKSREANKALMAGITQANEALFQEKERLHITLDSIHDAVISTDNKQNII
FMNPVAEKMSGWKQSEAQGKPLLSVLRITEGPDGEKLEALSAQAGPESDAAYDNTLKNRF
GGSYDIHYSMTPLKTLDGERIGFVLVIQDVTESRKLLRQLSYSASHDALTGLPNRASFES
QLKGLLKALPGTHQSHALIMLDLDFFKAVNDSAGHAAGDALLHEIASLMRSVLRPSDILA
RLGGDEFGFILRHCSTEQAVNVTERVVDAINHYEFIWAGRLHRVGASAGLTLVHEHNAKL
AELLVQADAACYDSKNNGRGRVTVYTPVVHTGDQSSVCQICNNA
>A0A1M5VJQ8|diguanylate cyclase|EC 2.7.7.65|Vibrio aerogenes CECT 7868|TrEMBL
MTHDLAIKKKIFCYEVKEFFVSGRKASYLDHVPELFNESLLAKFNIVTDVLNSLMFPDIP
EKEQFQLLIERYLELLSVLVQLEHHGCYTDHLTGLFNFNYLKTLEHELNKKDFTLYFFDI
DNMKQANDTFGHEYGNDMIVSFAKALKQSFRLTDLLFRYGGDEFIVIILRDDIDIDDVIL
RVRNQACIQKYNLSFSVGRHVNETSSLLKTMHQADSEMYERKKNK
>A0A378GRJ4|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MRKKQSLLVSVAVTCLLICLAIFFLYQRTLSQVNEGIHELQNQMVTLFNDNELMAEAAGV
RYQQISRHFLCGDADVFEPRGEAWGINADAKNIDNQHGALISRSPERSARCIYVAAEYIR
DKVRALNPEQHDIHRYIIASDGRWFYWFTPTDSIPFSFETSQMAHDPSHFFNEPEMFYDR
VLQKSVRKKSLSSTTFYSDKITGDKAYSVVSYIYDLSEGEPSNHIIGYLAYDLSRVELQR
MLGLAFNQQVPPGLIMGYQSKETGEVLCIIGNCGWLDSHRIHTVSSRYEIKYALPLWLFI
THTPQAQVMMALAPVLLLLLFLLIRYHLNHADLRFYRDPLTGCFTRNIFALIQQRALPFM
TVILFDCNKFKAINDSYGHQAGDRALQAISQCMLSDIRANGDWVIRSGGDEFVVLLSRTD
IAHAHMVAERIAAKIAVFPFSPQGQEVPLSVSWGVAPCVTTLDAAIQQADLDMYQMKKRR
GER
>A0A448BJL2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLACPLPPDEALRQQALDDMALVDTPAEHYLDALVELARETFGVKTVLISLIDHDRQWFK
ARIGLDAEQTPRDLSFCGHAILASEPLMVTDASRDPRFHDNPLVTGPPFIRFYAGEPLHA
SNGQAIGTLCLIDPSPRLLNLREGRQLNRLSILAEGYLQLRSLTEHTRFLRQEIDREQRK
SLLDPLTQLWNRAGFHALHQHELELARASDQRIGIIYSDIDHFKRINDTLGHRAGDSVLR
EAASRLRAALRPEDLLARFGGEEFVAMVRVRETTELTMIANRIRELMEATPIDCTGTSVP
VTISAGCTLAGSGEEPEQALARADAALYDAKRAGRNRVVSV
>A0A5E6ULT2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MDNQHGKGLSFARRIYMPRTIGLGIGSFSVAAALYPLHLPVWVWVLLALNGFVWPHLAYQ
LSSRSAFPYKAERRNLLYDSLCGGFWVATFQFNPLCTVTILAMMAMNNVAAGGHRMFLSG
SLSQVAGMMIAWSLFGAAYTLSTTQLQVWACLPMLTLYPLAVGMVCYRLAIKLSEHKRML
SALSRTDSLTGLLNHGAWKDLLQLKFRECSQRQQQAAIALIDIDHFKVINDTYGHIIGDS
VLRQLSIELKCNLRESDLAGRYGGDEFCVILPNMPLNQSMDVMERLRKVLQDYRHREVPE
LRVSLSIGLAAYQPSFTDATTWLEDADKALYIAKNTGRNKVSVNPGNIGLETSTV
>A0A0X4EWM6|diguanylate cyclase|EC 2.7.7.65|Enterobacter genomosp. O|TrEMBL
MQRDTFVVKQSFLQWLHKRSNPGLIVNLCFLTVLVFSTLLTWREVVVLEEAYISSQRNHL
GTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDVLQNAVSRFNAVRMLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLSRDAERISHEISAALEVGYLLRLASSRAQTESRVIYVSRA
GFFLSTDTPDRAGDITSRYYHLVTQAWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDHYWYGVVAMDFALNTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHAGNPVN
HFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFSTMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKILS
DTCRQKSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCIVLPGIDLEEARGVADRIRCRINSKEILVKKSTTLRISASLGVSGADEAGNYDFEQLQ
SVADARLYQAKQTGRNRVVWRDQDRK
>A0A5E7UKK3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLKQAVPLMVRHNIPPNPVHYALWYTYSKGQEPELNRHLDRVVNDFDCFPPESAAKLFRE
YIIRDELADARSGQQDAINLVDDMERDVSRSVRGNQNFQASLGQYLQMLEQPASERLPSI
LSELQQSTRLMQGQQEHFLAQLQSAQHEIKSLRDKLQRAQLAATLDGLTELLNRATFNRQ
LEQAMGNVAKGVALVMLDIDHFKQFNDQYGHPLGDRVLQHVARVLRDSLPEEAFAARYGG
EEFCVVLKDCPDLAAAGAFAERLRLKIQSLRVKARGTDTVLDTITASFGVAHVQPGDTPE
SLLTRADDALYQAKRNGRNQVRQQPDVAVGAV
>A0A5E7V0Z4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MGNTGGKGLSLARRLYTSRILGLILGLVCVSVAMYSLDPPLWVWALMFFNGLVWPHLAFQ
WARRARVPYHAEHRNLLIDAFFGGFWLAAMHFNPLPTATTISMMAMNNVAIGGSRFLLAG
SAAQLLGVGVGLVVFAPAFVPQTTPAQMYACFPLLLLYPLALGWICFRQAYTLGRHKREL
LALSRTDSLTGLLNHGAWKDQLEIAFQRCKRQKQGAAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKLLKQNLRATDVAGRYGGDEFCVILPELPLFNAAQAMEALRERFATLGYEQNPA
LKVSLSIGLAAYDPAHADATRWLNDADQALYEAKASGRNRVICNCDDKPRRTLLDSV
>A0A0B7DFS8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MKSPSQTNAIDFDSAKLQRLGFGQLPPLLERPTSLTQLRQQMSLQLQTSLEPQRILGLFF
REVQRLVPLDALSYEHKGSDLRLEFGARGHHSVSYSLSHEGEHMGEVVFRRNHRFNEQDQ
GNLESLLSSLLYPMRNALLYRAATQSALRDPLTGAGNRIAMEQTLQREIEMSRRHVQPLS
VLMLDIDHFKRVNDSHGHSAGDDVLKAVAASIKSQLRNVDMVFRYGGEEFLIMLSNTSRE
AAAMVGERLRYAAQAAEYYADGQLIELTVSLGCSTLLPGESAESLLRRADSALYVAKREG
RNRLAMAG
>A0A5E7QC78|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MARRLYTSRTLGLALGLLCVGAAMYPLDPAPWVWVLMLLNGILWPHVAYQWARRAKVPFH
AEHRNILMDAFLGGFWVAAMQFNPLPTAATLSMMAMNNVAIGGLRFLLVGTVAQVLGIGI
GWLIFTPLSIAQTTPLQLYACLPLLSLYPLALGWICFRQATTLGRHKRELLALSRTDSLT
GLLNHGAWKDQLEVEFQRCQRQHRGGAVALIDIDHFKTINDTYGHVAGDIVLRQLSKILK
QNLRAADLAGRYGGDEFCVILPDLPLASAAAAMDALRDRFATLGYEQNPALKVSLSIGLA
AFNPAHTDATFWLNDADRALYEAKTTGRNRVICCGDGRPRRELLDPV
>A0A5E7W1V6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEKTGGKGLSLARRLYTSRTLGLALGLLLVSAAMYPLNPAPWVWVVMLLNAILWPHLAYQ
WARRAPVPYHAEHRNLLVDAFLGGFWVAAMHFNPLPGATTLGMMAMNNVAIGGLRFLLAG
TVAQILGMGVGLLIFSPAFIPQTSQLQMYACLPLMCLYPLALGWICFRQAHTLGRQKREL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCKRQQQGGAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKMLKQNLRAADVAGRYGGDEFCVILPDLPLTSAAAAMDALRDRFATLGYEQSPA
LTVSLSIGLAAFNPAHTDATLWLNDADQALYEAKATGRNRVICRGEDEPHHELLNSV
>A0A5E6ZJR3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLDLDHFKHVNDGYGHPMGDRVIKSLALFLKQRLRKSDFIGRYGGEEFAIVMPDTDQESA
YKVLNQIRQRFAEIHYPAQPADLSCSFSAGVVQMQGEADSLQMASQADEALYRAKNNGRN
QVQPFHQTRPIATTCP
>A0A448BHS1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAPPKQSNTIDFDAAKQKRGPQPGGNASGPRASNLTELRQQLTLQLQSSLEAERILGLFF
EEVRQLIPLDALGYRHPGSDLRLEFGSSAKHSVSYRLSHDSDYLGELIFRRRQRLGEDEQ
RQLESLLGTLLFPLRNALLYRAAIQTALRDALTGTGNRIAMDQALGRELELARRNLQPLS
VLMLDIDHFKRVNDHYGHAVGDEALKAVAETIKDHLRNVDMVFRFGGEEFLVLLSSTPLQ
AACMVGERLRQAVEELDYRHAGEPLKLSISLGCADLRPGEGSDDLLRRVDEALYEAKRDG
RNRLRCA
>A0A240AW62|diguanylate cyclase|EC 2.7.7.65|Serratia ficaria|TrEMBL
MRLLRKNRTGHSRPTLGRVLQRVHLGLALIAVGTAGIFLTLVALFALRAYANHNLHLIAR
SISYTVEAAVVFEDRTAAREALMLIASNEEVSEARILDNSGKVLASWRHPKDGPLHGLEQ
VVAHWALPEPVILPIAHEGKQVGKVWLSGHGGSLLRFLLRGMVGMIACLVLSTLCALVLS
RRMLVGIVRSLDDIAKVAHAVRRDRTFGLRVPSAPIAELHELSGDFNGLLDELEAWQAHL
KQENDSLTHRATHDSLTGLPNRAFFEGRLSRALGDIEPPEKLAVLFIDGDRFKEVNDSYG
HAAGDAVLTTIAGRIRAQLRDSDLVARLGGDEFAVLLAPVHSTEDVLQIADNIIDCMTQP
VILPNDEAVITSLSIGIALYPEHAVTPQGLLHEADDAMYQAKHRYNGGWRLAIHK
>A0A1C6A230|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MDKKNTDITDPSIIVPADNCKDIYFSLFNSMYDGLSVFEVCGNKIRALYLNERYFDNVGY
TLEQYTPYIENVTVTLFEEDEQRIFGLAQDCIRNHSDFYCEVRGYRYDGSVGWFCIRART
VDFIKSDNPVFLASINDISRRKELEHKYNISKERYRILEETSSAFLFEYSLLNDNMTFFP
KAGKSHEIVNYGMYLRRSNRIYPDDAIYFYYILMRCCRKECKGFIDIRYLDNVTEEYIHS
RVHYSSIADEFGFVLKIVGRIEDITEQNGIKADLIAEKYNAPYGTLPAAGDAIAQISEKI
SHEGTKGALLFADIDDFGDFNSRYGKEAADNAVALAAEIVGDVFSDSVVFKFPDDEFVIY
TENMSEPDLHDRYEKLQAACRTIKLTSGNTVSDIGITFSVGAAWTHNSSKVNMKDYFITA
ERVLYKTKTDGKNRMYVEKIIF
>A0A5P9JGE9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MSPVRDETDERTLQQLVTRRFAMASVTYGLALLLTWVAVAGGFYQATISSAVVHSALIVL
SQLAFFWLFHRGINLRFKDPSLTEPQVLVALVWLTYFLFNLGSARGSLLVLYLLVLMFAV
FLPPKVFVRYATLAFLSFIGLAAMDYYLQRTVDATVFLLQACVLLVTLIWMCLLTGHVYR
LRQRMRQRRFALQAHQDTLRGMMRQLEDLASTDELTGLYNRRRFLRIAEGDLSRLRRGHQ
SGLALIDLDHFKRINDIHGHATGDRVLQTFAKVARTCLRDDDVLARYGGEEFVLLLPETD
AEQFRACCERLREAFANAEPEDADIASGHLSLSIGLTLLNAGDNLDAALQRADEALYRAK
RAGRNRCEAAWDVCNA
>A0A1C6DU33|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MSGKLTVGVFIHHLDNDYSKAFLKGTAAAANDLDVNLAIFPGRALDCQLADRRYTVYEYQ
NNVVYSFASSKSMDALIVSAGTIATCVSHDEFKEFLGGYEGLPLLTTETKFEGYPCIRLS
GSGIKELVSHLVHEHGRKHIAFVSGPEGNTDADERLNYYKEALAENGLEFDPDLVTYGNF
SEYCVDIVTDLIDRNEGKIDAICFANDMMCRGGYKAIESKGLRVGKDIAVTGYDDSEVAA
TLRPMLTTVRADASVLGYRAVEEAVHMAKGEKVEDICIDSTPVFRFSCGCIFQAEQKVTL
DNLDEASVRKAVDNILSEHIQRYEVSMRKHDCIKRLHEFAHKLMSYAAGADISVEELFSK
SYFSRIMDSDIWKLVSPEAFLRIMKSIRSASLSACEGNMMGRKLNVLKILEGSMEVASEC
IVNMHYTTMNDITFTHFLIGNITKDMTIYDSDDEKCYFSIVNDLYRAHVDSSFVYTFEEP
IIHDPESEWKLPETILLRAYNDGDKLAAVTGEACKLPSSRIITNQYTPNGRNRIMVVSPL
FMNEEQYGVIVCEMENEYFTYIYSITPQICSAIKLTNLVAKLESSLDAAQSRNNVLNRMS
MIDELTGVYNRRGFYVSANRILKAPENEGRQAAIIFGDLDNLKKVNDTFGHDDGDYAIVS
CAEFLKKSLRTTDVVGRIGGDEFAAFAICDDADIIAQLPSRIKGIAAKHNEVSDKPYNVT
VSIGIYPIICSPELNIQEFMDKADNALYEDKKKKNPDIMKHNM
>A0A1C5LLR5|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MVVVYPRSSTDALTLDLSKGTLLPHTDISDKNNIYLFLPVHFREREVGYLILENCDYLLS
HQFLFEMLNTFRTSVEALYGRLILRKKNRQLSQLYIHDSLTGFYNRMAYEKLALPLFQQC
MQKGRPVGIMFADADHLKYINDSFGHDMGNLAISSIASVIQQQCPVGSISMRYGGDEFVC
VIPDYSQSKMQQLKNSILASLEQLSANSHMTFPLEASIGFVVADDPAFSLNDYINLADEK
MYAEKKEHKATRQ
>A0A5C5Z9C5|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium CA13|TrEMBL
MQMRAISPQENKGIGSLRFPNDSVGSCFWNNLMLLDLAIAFSCAGVGISCGWVMHGLGWI
ESSDEAAVGQISRVAVELKQVHDEQDRLSIVAERLRDYALKMAIDVDEHQHNVQEVSDSL
TGEKALSAEAMCAAVNRLIEANESMQTKLHSAQQRIHAQAEQLESAERRAQTDALTSVSN
RGAFDEHLARRHALGAGRAGTLMLLDVDHFKKFNDEYGHRAGDEVLKVVAQMLHARLKSY
GIVARFGGEEFAAIIDGYSVDECKKIVESARVAIGQQSIEFEGNVLNVNASIGVAEQIDG
DSVEQWIERADAAMYHAKNHGRNCGFWMNENEPTLISLDGKVEKKTRPAPKQEPKREEKS
FLIPEVDEPIAADGVKETVADTIKSVGKKKASTQKTESEATETPNKPEATKNDSPNQEPA
PQKTPAKNEEAPSRGAFASLPGRAALAGSFAELQERSKAIGKSTHIMALHVTGEPVAGSM
RALLQIVRATLLSVDRIGAEDASTLLVCIPGIDANTAQQRLEQIQASAASIQFGDSAKGT
VEKLEIGLVQVSEKETFEQSLSRLLG
>A0A5P9JKQ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MPPNPVPGAGIDANAADQPIGGIASILDRLDALVYVADMQTYELLYLNEYGRAIWGQYQG
KACWQLLQAEQQGPCRFCSNAQLVDPDGRPAGVHVWEFQNTANGRWYQCRDQAIPWTDGR
LVRLEIATDITERKRMEQQLHLAVSRAETLARTDELTGLNNRRAFFELGERAFVHNRRPR
PMAVVMFDIDHFKQVNDTCGHAAGDQLLRAIAAALRPLVRPADVLGRLGGEEFALILADT
ERDQGLAIAERLRLAIAAVAVADGERTVRCTASFGVSACRDGSSTLDAMLSEADLALFRA
KRGGRNRVVQGRSG
>A0A087DHN9|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium stercoris JCM 15918|TrEMBL
MTVVTLFNIAMELWGVLICIVCAGGVYVGAIRRTRRTYTKVSMQLLCALMLLADVSAWYH
NGGCDKLDFYMTRIGNLGEYLINFIFIALFANYIWQTVSGDDMLENVSPHEWRARMSGGA
KRNRKNQRSANARSKPKKPRSKKLDVIYAASALGIVLTIATQFNHMVYYIDSQNYYRRGP
LFAIPQILGLVELALIVMLIIENRKNLSRPLFVTSLSFFVLPIVTTIVQILHYGLALQAI
AITISIQFTFVVDTIEMNKKIRSQDDAYQKASYEAQHDGLTDLWSKSAGREQIENYFAHM
QEGDQAVLIFVDIDDFKQINDTYGHKVGDFWIREVAQTLKRLYRHDDIIVRFGGDEYVAL
IKNTANERVIESTLDLFRRQLAQASAQYGQDVHCSIGACRVLSGKNVDLNLCLGFADHAL
YQSKREGKGMYTVVDYDSGKVQAA
>A0A1C5MB05|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKKKKNISTHYVAAIIIFICAVVISLGVFLLYVQKSIDTNSQKTMTSNVAKQSDHALSIL
NIHYGFLNSIADKMGDSSDILSDENMELLVSLAANTDFERTALIEADGTAYYDNGAIKNV
AQRKYFLEAMKGQATLSDPLDSSIDQETRVILCVPVRCNGRIIGALGGSYNVTALSQMLF
NDIFDDAGYSLIVTKEGEIIAYDGEPSYHKITYGDNFFDFYKDRTLLSKNSLVNVKKDFS
AGHDGLIKIRTDSNKKSDQYIAYTRLGMNDWMICYVIPVSDAQSSYSFIKSYEGIFMSVF
FILVLLLVFYIIHNNRIRNEELRRDAQTDGLTGVLNKRTTEALINEILEQRPHEKGTFII
LDVDKFKEVNDHYGHAVGDIVLSTLGQTLRNYFRENDIIGRIGGDEFVIYMCKTESKERA
VTRILALADTVKNLSFAEMNGHHITISIGISFAPEHGTCYMDLYKNADTALYETKQNGRD
GYFLFQKQDSII
>A0A7Z8DXU2|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MLHEIKIEKQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVASALDKQLQYNVDKLMFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGISDALVSQGSLLSRENNSLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRDVPTRYYEFVTQPWFIGHSQRENRQRAVRWFTSQPALSSHTEPQVTV
SVPVDSDNYWYGVLGMSIPVRSMQQFLKNAIDKNLDGEYQLYDSKLKLLTSSKPEQSAAD
LFEPRELASLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHKHPFSIIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISHSLRAQDVAGRVGGEE
FCVVLPGTNLAQAKDVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNP
>A0A7T1F377|diguanylate cyclase|EC 2.7.7.65|Atribacter laminatus|TrEMBL
MIEYNYLFSIVCLVTATLAITLSFLSFWFSRFTPHARPLGFLLLFSGIYAFGYAFEIMKA
DPEWFFLWLRVEYFGLSFIAGSFLWLSIEFTGSFKTHKPVILVVLVGVSLFFLIVVLTNN
FHHLYYSSIEVDYRGLFPTAALGRGIFYILNILWFIVSFLLSFILCLHHFFQTTAILRKR
ALAMVIAVIVCLVNYLIYILKVIPWSLDIGPLIISINGFILSIAITRLAFLNISPIAREQ
VFESMQDGVAVTDPQGRILDFNVAAHHIFPNLIQENIGHHLPTLVPELKPYLSTENISRY
NPLSIQKDDAVLFYEARKISIKNKQNKKIGMALYIREFTEQYKLLQKLHEYAEKDWLTGI
WNRRKWMNLAKTELKRAKRYGRPLTIAYLDIDHFKLVNDNLGHEGGDTVLIQLVKNISSQ
LRENDIFGRIGGEEFIILFPELDKEKAQMVTQRLLMTVCQEEIIACEQKVKVTISIGATF
WDGDKKESLEELIQKADKALYMSKAAGRNRATFI
>A0A210PC72|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus kimchii|TrEMBL
MTWSVWHVSPFITSVFFILGIFTLYQVLYDGLKTLLHSKNIKIDDDSLNSIFGVLYMLIF
IFSMQATLVGTPISWQFMNFQLIGLIFCAYFLNIKVPTYYFFPIMVLYMIFNGSIGYWES
WLHGIILMIFYISLNKLRRRQKYRHPFVCYMLMGTVFGGMLWLCMKIKFALPMATFFEEW
FYLVIFEALLFSYVGMILRDSQLKIKLLQFANHDALTKTENYAAYTAEINNLFDSSSRNK
LDLSMMMFDIDHFKQVNDTYGHLAGDKVLQHVADVVHTVINANDPKVKLYRTGGEEFNVI
FPGYDLDSTEPIVKEIFAALNHLDVNIDGEDISITISVGVSMISKKDTEPNDFYTRVDSN
LYRSKRNGRMRITVA
>A0A5Q2T539|diguanylate cyclase|EC 2.7.7.65|Kluyvera intermedia|TrEMBL
MHPLTVKTVASSERWWVKLARRIRPERVVNICFLVVLFFSTVLTWRETLVLEEAYISSQR
NNLKNVANDMEGQIQFNTDRLLFFRNGMQSALQIPLAFEILRTAEQEFERKRAQPEWRIS
LNNNRTLPLNGVSDTFVENTALLSRDNSLLGNEFMATIELGYLLKLSSMTRQHLSRFETH
MIYVSRAGFYLSTEGEPSSTITEYYYKQASSPWFMAQSQRDNPARGVKWQTVFSQGKNPV
AQEVVAAAPLDFQQYWYGVLAIQLSVNEMTQFLIQAVEGDEEGEYQLYDRRMNLIASSEK
EPSQQTKLSPEISAKLAYAYEHGNDGNVRALSQFISWEKLRNFDGVLIRIHSLDEGIRGD
FGSISIALTLLWVLFTSMLLISWAVIRRMVRNMSSLQDSLAWRAWHDMLTRLYNRSALFE
GAGKALAACQLNGRPMSVIQLDLDHFKSINDRFGHQAGDRVLVHIGRVILNNVRKHDIAG
RVGGEEFCIVLPETSMEQAVKIAERIRESIYGREILIGKNQTIRVSASLGVCSSEELVRY
DFEHLQSVADGRLYHAKKSGRNQVCAHDVENQ
>A0A654A6J7|diguanylate cyclase|EC 2.7.7.65|Sphingomonas sp. T1|TrEMBL
MATLNALALLDTEPEREFDALVALAAEMLDCPSAMMTLIDRDRLWIKAANDGERGEIARD
VTMCNVTIQGSAPLVVEDLSGDSRFAANPLVAASDGVRFYAGAPIHAIADDGRRHPIGAL
CVLDTHPRSLNAAGRKALVHLATLAEAAIAARTAAMQALAIAVTADRQSSVLARQDRIFR
QAERMAAIGSWRVLWPDGLLEWSDGVFRIHELPLGAQPDPSKAIDHYPPHAREQIAQALT
DVIRTGVPIDLELDFTTALGNPRRVRVQGELEHAAQRNVDGPVAIVGIFQDVTERHALEL
TLRRTAETDALTGLANRAAFDRALDAAITRARAAATPLLLALVDLDGFKAINDTLGHNAG
DDVLRGVGQILQAPWLRGSLAARLGGDEFAVIVDDPALVGAPEEIVSRLQEALQVPVSVD
GLAMISAGTVGIAALETDCQTVRDFVHRVDIVLYRAKRERIGERRRAA
>A0A8H8X888|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MTSQSWLSLVNKKYQLSLRLFLFLNAASALFSVTNPLYSVRVLSVPLFAVMTISTGLLIW
HWKNSTRKINIPVVSAIFGLLWAWQIVSKFLLITHDHATYLMMALLTVLFIGSLAFASNI
KAFTLHSFPAFISCLWLSPSENWLRMAYFFALPVVAIGIHHVLQRRNDRFAQELLSELLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPKPDAGEHFVLLMDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVARFGGEEFMVLLSNIPLEQARQTAERIRQKVYDLKIPHM
FNESVATNVTISIGIAMFEGDDVEGALAKADKALYEAKHMGRNSILLSEELHTA
>A0A2T0B8I8|diguanylate cyclase|EC 2.7.7.65|Clostridium liquoris|TrEMBL
MNNKLYIAKLENKIKTLQEEIELNKSKKCDMTLEESEEIYKSFFEHSLLGQLYIGIDGSF
LKINKSFCNMLQYTKEELMKLKIQDVTYGEDLEYTEYILKKAANKELTNFCFEKRYVAKN
GQILYCRLSSSLIYDNNNNPKYFVTQIEDITVRKISEENLRKFQKAIESSSASIIITDKS
GHIEYVNPKFSEITGYSFQEVLGKNPRFLKSNHNPPSEYKELWETILSGNPWQGEFLNVK
KNRDFYWEKAKISPIFNSKNKITHFVAVKDDITKQKEIETFLYESNKRYENLSQNIPGVL
FQFMISAEGKLSIPYANMATNKILNISPKDLKNNPDFFISNIHKDDLLNFKNTFKISKET
LTPFHWTGRIVIDNNIKWLQIDSSPSKTNDNGLLWDGVIIDVTKEKINEEKIKMLNEELK
KLSYTDALTGVFNRRRIIEIGEEELNKAKDSNRKLSIGILDIDFFKKVNDTYGHINGDVV
LKTISAKCSELLESEGYFGRFGGEEFLFILPNKNAQEAYEMAQKMCNLISNKTIKAGEYD
ISVTVSIGVSEANCGSDLNVAIKNADTALYKAKNNGRNRAETFL
>A0A8H9S4X4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRTFLQWLHKRSNPGAIVNLCFLVVLVFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQFSVDKLLFFRQSMGDALQTPLAFDVLRAAVTRFNADRSRPFWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDDELLDNEVSAALEVGYLLRLASPVMRSEERVVYVSRA
GFYLSTETATKTADIIPRYYHLVTQPWFTQQTERNNRARAVLWFITSPSTWTGNERMITA
SVPIYFDHYWYGVVAMDFSLNTMKRMLADATDDHAEGEYQLYDTRLNMIASSEASTSEAN
HFDERETAQIAHAIENNTGGGIRLGSRFVSWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLHNRGALFERAKALA
GQCQAQSLPFSVVQIDLDYFKSINDRFGHQAGDKVLSHAAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARAVAERIRSRIDSKEILVKKSTTLRISASMGVSCAQEKGNYDFEQLQ
SIADARLYLAKQRGRNQVVWDDQDKK
>I6DPK8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKYPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>I6ED28|diguanylate cyclase|EC 2.7.7.65|Shigella boydii 4444-74|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIVAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLVINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A7H9JXK9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHNTFVVKQSFLQWLHKRSNPRLVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRASPTWQIEVDK
QRTLPINGVSDAFVEKTTLLNRDDEFLDNELSAALEVGYLLRLASSSSGNEERVIYVSRA
GFFLETDTPENASDIVQRYYHLVTQPWFTQQSERENRARAVRWFISPPSSFVGKKPLITA
SVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLATSGSSAADVN
HFDAPELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLEEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGALFERAKILA
KQCEQQALPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKDIAGRVGGEE
FCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEKGNYHFENLQ
STADARLYEAKQRGRNRVIWQDHVKK
>A0A1W6KF90|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MLYRLKTDFRLSIITLLAISAILGITPFAVMRFVQGNVLAGVVDLGIMLAITAGMIYAWI
TGDTARSGFAMALVACGGAVTVGALVGEPGLFWLYPCLVTSFFLTEPRYAIFINLAAVVA
LMVHGVAFSSLVQMWTFAATAMVVSCCAYVFAHRNENQRERLEHLATIDPLTGVKNRRSM
DQELAMAVASASRNGISYALVLLDIDYFKKINDEYGHNVGDDVLVEMVALIEQNIRKSDQ
LFRFGGEEFVLLMPGVDSTGLKAVMHNLQHIMHKFLRHPGGQVTASFGVALFQAGEKPDD
WLARADEALYEAKDTGRDRIVYADDMVASPA
>A0A7H9JXV9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGSLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWESINLTYTAINIIEACVGAVLLRKLLPWYNPLQN
LNDWIRLALGSALVPPLVGGILVHFLVPGAEPLRNFLFWVLSEAIGALALVPLGLLFKPH
YLLRHRNPRLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPPSMTPSNMMVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLINGEINSYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPPHIKPTWQLWHAAMV
PEDRAHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPV
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHAIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDANYQTAEVMSQADIACYASKNSGRGVV
TIYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMNTLSG
IGIDFIYGDTIGEAQPLDLLLNTSYFAIN
>A0A1W6K4X2|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MSLKTRLLGLAAALMIIASVASWLAYRELSDDIIERWGQQVAEIQVRYDSARLLQSLERE
IGLARQMADSSTLVNWATSPEDKALQSDAIREMESFRSNFRDNSYFVALRDSRRYYYNNA
NNEFANDQFRYILDPDKPEDAWFFQLIEEGRNFHLNVNPDTELGVTKLWIDVLMRDEEDR
IVGMVGTGLDLDAFLQDIVDIDQEGITTLFVDYNGAIQLYRDRNYIDFASIIKPEGQKST
VDLLFDNPEDKQKVLGMLQLLKNRGGATGAVESSFVTVDGRKHLAGVAFLPAIGWFEITL
LDLETLLPRSYLWPLVAVFLTSLLVTLILFHLIIRSRILKPLVSLESAVEKVRGGSFALP
HLEKPDNEIGRLASHFETMTDTLEHSTRELERKVAQRTDELNRLARVDALTGLKNRRGLD
EALDEEIQRAKRQNTGFGLIWLDIDHFKAINDELGHQAGDDILCRVALWLKAGVRPYDHP
GRWGGDEFVVVLSPCDEDTLCQIAARIRETIERDSIRTGTPVTVSVGGYLCQPGDDVDTI
LRQADQALYRVKQQGRNKVLITDGSGQEINPA
>A0A1W6KBV2|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MSRPKSMSAREPIRERRPQFWQVAKRCCQIAATVDVAFFFLFHLLGSPILAWVNVVSVTM
YVVAYRALARKQNGLAMSLIWAEVIIHAGLGVLLIGWESGFHYFLLMFIPALFVSMALRT
AVIFLVALWSYYITLYLVMWVIEPLQPIAPGALLAVYLFNLSVVFAMFSYLSFFYLTMVT
TANRKLRRMATTDSLTALFNRRQMTELAEKELARFQRTGRPVAFLVLDIDHFKAINDRHG
HEVGDRVLIEVANLIKAQLRTQDLISRWGGEEFLAVLPDTGLDSAQASAERMRKALLAHD
WLATTGEPIDLTISAGVSELRPGDNLNSAISRADRALYRSKEGGRNRVELETI
>A0A240ELF6|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MSPSFASSNLFRLFIPIIMIVGILAGLNHIIAATQANSGFVTNLPYILFGTAFALSHSFK
QSRIAMVALSMLLAYAVIQVRLQTPLSTGTTLLELSLLSLLLPVACCLAFLFPDTGVLNK
GMYIFSAIVVSFLLWSYLILSHFDNGGFNHFDNDLLLAIPEVSRLPLVLVLYSFAVTGAT
GIFLLNYNRPIDAVIYTSILLSSSTFIFFHVPHMSSTLFSLAGILVIIYVISASHQMAFN
DRLTNIPGRRALEMDMKHLGRKFTIAMLDVDHFKKFNDTYGHDTGDDVLKLVASRMLSVG
GNARVYRYGGEEFTILFKGKTAKDSKVYLDELREKIADYEMVIRNNAQRPNDNKKGAKQR
GANSQGSTVSITVSIGAADSKTTKKPEEVLKKADKALYTAKEKGRNQVQCAR
>A0A240EM33|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MKHEIAAFKRHDQEICCVMLDVDGFKSINDRYGHAVGDYVLQTVGKILIESTREEDFCFR
FGGDEFTILLPKTSLPDAYKFAERVREAVANRALYSTIGEAFNIKVSLGVATMQQGKEEQ
LLAIADEALMEVKTNTKGKNTTYVFCDRMLAIFGCDGCTRAGRCK
>A0A7Z0VIW5|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MDDLNSRHQTEFHLKSTFWLSVTAATLILPFAFYHLTHQHVGIGIGAVITSLSLYLVAWS
CHKKTYKTIYTFVWLTPFTTLFVAYLTNLLGITGTYWCYSTLILYYFMMSERQAWISNII
FALVNIPLVWHLFETHEAIRFTVTFSLVSAYSAIFLHIIAIQYSELQKMAITDKLTDVYN
RTLLKDSLEQAIHQANRTNTAFTLIIMDVDHFKKINDELAGC
>W6QPY9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MQACMASGWSFSAPVLVTLLVCLGVILLAHWVTRQRDFPGRDSFILLHLASLWWMGAAAL
EMSFFAADCKMFWASMAWPGIVATPTFWAVFLWQYVNSMRAPLARSSILGLSLVPLLVWA
LALSNPWHGLFYGAGSAPVDASLGAPVRYEHGPLFYATAVYVYLFMAFCMGVVTRAAALS
QGLHRRHYLAFVLVTAVPWVANIGYVGFGWTLFGFDPTPFSFAFTLMAFSWLIVGVRLFD
LLPVARHLLLEALLDPVLVIDPRGRVIEANPAALKLAGLQAGWQGTELGQWPVFGADLQQ
LLQEHNGPEQDLPLTLTSAARYYEVRVRAIQRATRHGPTLLGHMLYIRDVTQRHLSELKL
AEALALSEERLRTISSLHEQLREQALCDPLTGLYNRRYLDEFFERELARAQRENLPLALA
LIDLDHFKRLNDECGHLVGDDVLKAVAQHLLDNLRSTDAVFRIGGEEFLLILPGADPREA
SERLQSICAQLATRDVATRGGDQRVTLSAGLAHWPEQGQALDELLQAADAALYQAKRDGR
NRVCGLLADADLSHPSRQAALRGDSG
>A0A517NX27|diguanylate cyclase|EC 2.7.7.65|Planctomycetes bacterium K23_9|TrEMBL
MHDCLNKVLNNAAVPSPPTVAAEILDLVAQSESTIDQITQVISSDPNLSGRLIAYCNSPI
VGCKRTIGSLPQAVVVLGLRKLRLIALSFSLLETKDENGFDYEQFWRRSLATAIASQLVG
ERSNGSSQESFLQGLVLNVGQIGLANTFSKLYSDLDTDENGTVCTVDESEMFGIHRYGVG
AEMLQKWHFPEHMVDAVGQYDPLILNHRTKPFQLAERLALLLTSDNIAVHQIDETKRVAE
AWLGIDSIAFAEIFEQMLEHWKSFEKLFQFDSIPFDSLGEMESIAKQRLIDMAMGMDSEV
EVLRQEYQDLKRSSLVDVLTRLKNREAYEFEVPGVVDYHRRQKKSFGILVIDIDHFKSIN
DTYGHAGGDAVLKAVGECLIQNCRKYDTVYRYGGEEFVAMIVDCVQFSTERIADRFRAAI
EALRIPFESEMLKITASIGICWTEHGETESLDKLFQIADSNLYHAKHSGRNCCVVRPESP
GVSIPVS
>A0A447TH87|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPAGALLLGLGDWLLSRRVRARSLLAGYALASAAVLLSSAALLYFASLWAGGSVVAILLL
LSGTMRYVSGQAQLFSLAFTDGLTRLYNRRHFDEAFGHAVEQCRQKRKPLALLILDIDHF
KKYNDHYGHYAGDEALQKVARALKDCFRQKGQLTARLGGEEFGVLLTPGDTPQALSAAER
FLGRLAAMELPIPPARSARSAAA
>A0A564UXZ9|diguanylate cyclase|EC 2.7.7.65|Escherichia fergusonii|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLADERLYKSKKNGRVQISWQ
>A0A0X1U8Z6|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MDNVNVLLEHLSVFKNLYEMVRIVDPINKRVIIDNKGYIPTVGNCFDLWKSKSYCSNCIS
MRAYNEENTFVKIEYNKEKIYMVIASPFNIGTNKYILELLKDITDCSIIENYVNKTVDEV
QKIIEEMNNKIIKDELTGIYNKRYINERLPIDIIKNSNEKNSFSILMTDIDHFKFVNDNY
GHLAGDKILVDFAYILSKSIREGIDWVARYGGEEFIIVLNYADNSIAYEIAEKIRRSIEN
NIFTYEGQEIKITASFGICTMPNDDMDWKANDMILLADKKLYEAKNTGRNKTVK
>A0A447TBH8|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MATTPQGEEEVRAVVQVPSTGWFLVARLPGSEAFATVARVQNFTLRQALIAFLVFSVLAC
GGMYIVLRPLFRAARHADRMTRGELPLEPLPIRRKDEVGHLIAAFNRLLRKLEDKQTELA
QMAHHDALTGLPNRSLLSDRLHVALAQAQRRDTRLALLFMDLDSFKLINDSLGHKAGDKV
LWQAASACPASSGKATRWRG
>A0A110A739|diguanylate cyclase|EC 2.7.7.65|Anaerotignum propionicum DSM 1682|TrEMBL
MKIGADINIFVIILLALIILIGKTAVQGQKNFKLFYRVIVFFILTLTAGSFYYFTEGATL
KGFVLFSHFMMIAFHVFGAISAYSWFIFVLHETEDNLHCNPSLKNFYILPLIFQCTLLIS
CGIFYYDEKNQYLQGYLCIFQYLLIFGYLFAGASISFIKYIKEKRYAQQKNCFFLCLFSL
LPLLGMGIDVVFPNLNSILPFLVISIVMQYLNLMKKEIFQDPLTKLNNRREFQRHLVTVT
KTIRKEDVFLIFFDINDFKSINDTFGHVEGDRALVMIAQILNAAFSNTKAFIARYGGDEF
AVILKKEEPEILSYLKKVDASLVTLSASLPYNISLSVGYSVYGEENANTIESLIQSADKK
MYWNKEEQKKTICENESMASFHSIP
>A0A3S4I6D8|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MAGGQRLSGIVRQSDTLARIGGDEFVLLISDLDDKAEDVARTVANKCLEAFNVPFLVSGT
ACQLGISIGIAIGDGYSSADSLLQAADQAMYRVKKTGSSGSATICL
>A0A5K1I3E4|diguanylate cyclase|EC 2.7.7.65|Halomonas lysinitropha|TrEMBL
MRHSNNDVTGETRNGSECHALTSRQRDEMALFQIFFEESRDGLVVLREDGGVYCTNARFA
VMHGYTLAEVEQLYLWNWNSQYEKSRLLEILRSVPMEGEHFETRHRCKDGRTIDVEVATN
ATYLHGQKLIFCHCRDITQRNLDRERIHYLATTDPLTGLANRREFMSRCEAEVARARRFH
RPLALIIYDLDHFKRINDTFGHNVGDRVLQAATKQIHRHIRQEDLHARWGGEEFILLMPE
CGLDAAMASAERLRRAIAQYAYPHQETVSASFGITVLAEGDEIDGLIKRADDALYRAKAA
GRNRAEIERPDVSSA
>A0A3S4WWX3|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MPTAPLAFNTRRAGLNFARRLYLPRIVGLAIGFWCVLTALYPGHQPVGVWILLAVNGFIW
PHIAYQWSIRSEAPYATEIRNLLIDALLGGMWVAIMGFNALPSVVILSMMGMNNIASGGP
SLYFKGLMAQIIGALVTSAILGFPFTPQSTPLQVYLCLPMIFIYPVFLGYVTYQTAKRLA
EKQQELLRISTRDGLTGVFNRRHWEHLLHNEFDSCRRYNHTATLILMDIDHFKAINDTFG
HGLGDEALIVLAEELVLGLRAMDIVGRYGGDEFGAVLPNTSAEQASLALHRIQERLNEVV
FREAPELKLNISAGIADYQPEMPGYQEWLKAADIALYRAKNNGRNRQELAEHQC
>A0A1Y0NCB6|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MLKEISGFQGMEHLDLLPSPVLVTDPQGHIVTANRDLLALVGGAAEPWRGRYMDCLLPAP
GRIFLQTHVWPLMLRHGAVQEIYLHLNNAAGEQVPVMVNARRGLWDEQDCIFWVFFVALE
RSRFEAELVEARGRAQRLAAELSLANAELRSVHQQLSQHTQSVETENRELSALSLTDPLT
RLGNRRALERAVEQWQMQSELGTPAALLMVDVDHFKRVNDSHGHEAGDRVLQELARQLQA
SKRGSDVVVRYGGEEFALWLPGAGPDGASAIAQRVHLLVQDVRVHKKPVTVSIGVSCAQQ
TLHQGRDMVFLTRLLHQADLALYRAKSAGRNRTMWHDGPTGLS
>A0A8B3JR02|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. WCHEn090032|TrEMBL
MDKDFTSTPRPTFKRTLRRNSMISVIITMTLIWVLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDSLAANETLAALGKQGQFAVAEVVNAHKKRFAYWSWNPEDNNDTLGALVS
RWLFPVPVAQPIMHNGAMVGEIRLTARDSLISHFIWMSFAVLTGCILFATVVALTITQSL
HHGMVTALQNITDVVHDVRTNRNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNSIAALMNDPSARTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEVASRMMEFGDKRHQSYRLGGDEFAMVLYGVHSELEVQHICAALSQQFIRPFDL
HNGQKASMSLSIGFALAWENASMEALLERADRNMYQVKNQRTKTIS
>A0A1V4IWZ3|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MDKILVKKEELINKMEELILRNEGPFSIVVADIDDFKNLNALYGDFTGDEVIEKLISILH
NNLAPTDLIYRRGDEFNILLVKKGAERSFMELEEIRRYLSDNTFSLGDDKEKSLYFTLSF
GVASYPRDAKNVVELFRVADSALFRAKELGKNRICLSEAENMVLKSNYFTKTQLDRLSRL
SKSTDRTEAFLLREALDDLFKKYSR
>A0A8B3JQE5|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. WCHEn090032|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFIVVLVFSTLLTWREVVVLEDAYVSSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDALQSAVSRFNTLRVLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDAERISNEISAALEVGYLLRLASSRAQTESRVNYVSRA
GFYLSTDTPEQAGDITSRYYHLVTQAWFTEQSERNNRARAVRWFISTPSAWTGDERAITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNLIATSAHAGNPVN
RFDERETAQIAQAIEHDTGGGIRLGSRFISWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKMLA
ETCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHTAGLIATGLRKNDVAGRVGGEE
FCVALPGISLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSVDEKGNYDFEQLQ
SVADARLYQAKQTGRNRVVWRDQERK
>A0A0M9ISE2|diguanylate cyclase|EC 2.7.7.65|Achromobacter aegrifaciens|TrEMBL
MYVDLLTLYFIIIGTLLASAGLTFWEHRTHPSRSGSLRILAAGFATLAVGCTVALFRARL
PSPLGSAVANLIVLSGYLLIMNGAASLSGRRHRGASIGLLVVMALIWLAAGAQWEDLVWK
YISAFPIALVSGVTAWELLRCQSLRSLTPLRIATAAVTLHALVYAARAFILPWWVAEHGP
AIHLTASTLTMYEGVLYSIVLPMTLLKLIREETHGQLLRESQTDYLTRLGNRRWFFEQGA
RIIEGGAGRGPVAVLAFDLDQFKAINDRYGHQTGDQVLKFFADSARCVLGDDVLLARIGG
EEFAALLAGPDARRATVLGAAVAQRFSVTVSGRDDSLGIPATVSVGLAQFEDKVPPLADA
LAAADRALYQAKALGGNRVELAGAAASAVNC
>A0A7Y9UPL0|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. IAR9|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAICHRAECDIILLDVMMPDID
GFEVCRRLKSDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERSAVADTGKGGRILLVDDRPSSYERLATILAAEHT
IDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADPENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQASTRGKPLALMILDIDFFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGAKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>A0A7W4KQ47|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTIRNAKNLSNKTLRVRFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3Q9E7T7|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MKDSNEAISQITLLKQKLHSAKVALDELNEDRNTKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHQLSTFERLDDALPELVEVERLLKGQYHHVMAQLEESRAGLGRVIRQIQRVDSVP
DKLKKEVTYFKQDLAKPLHTVWEYIPKVEQLIGFYEEILAQQFQSGEKLAVLPKHRQLAH
ELAQMISEIEFRKDQRDQVLVIKEMLAGDIEVEGLLDAYQTILSLLIDNIAREKSASQEF
LYALNDALSAVREVVSDSYNHAQRSHQLKHQLNREINTRVDSVGEAIVDIEDIGMLKSQI
TEQLSSLRSALARKEALEQREQALLRKSMETMRKELNELSEEASNYKERLFEQQKLNLLD
SLTQLPNRAALEERMEQEFRNYQRHKHPLWVAVADIDHFKSINDNFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLLIPEVSASDIEQLLNRVREKVKNIPFKFKNQRITVTVS
IGAARVMDNELIHETFERADAALYKAKHESRDRVIIDN
>Q0T7K3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype 5b (strain 8401)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIVSTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVVLTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A370VAW5|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSAMLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLGGCRIIFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A8J8AWY7|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
MFPSGHRWSTRDLLTAAAFAAAGAGGASLGIWLSAFNVDHATLWLSTPLLIGLTLEMAPA
RRWLAIAATAGGELAATGLHGIGIGIALPLTLVNVVQVVASLQVLKRMGVRRGVLPGISG
FTWSMLLVGFVLPALTAAVVAVLGRGFDPETAGIFFTWWTSNLTGILLVLPLLLARAPGV
TQRRTRRPEFVLLAVLVVLVAALAIELLNQPFVMITLPLLLVAFRATTFGTALLCTATLT
VVVGLHLANVRGWTGDAAPSTLTTPETFFYAAMTVVAPLYVSLLLTSVRAAQERRRHAQH
QLQAVTDNIPALVGYVDADMRYRFNNARYEEWYGRTPRDLYGRRPQEVFGEQLAEVVVSN
LAECLEGNVVHYEHELPTTGRYIHAICKPDRDPYGAVVGAFILVNDLTERRTMEEELFRE
KERAEVTLRSIGDGVATVDVGGRVTYLNPVAQALSGWGEDALGRGVDEVLPLYEGQTEEW
AVNPLREAITYNRTVEVAADVDLVRRDGSRLAIDHSAAPVHDREGRVVGAVMVFHDISQT
RALHERMAHMAQHDYLTGLPNRALLTDRLEQALRRAERHGNALALMFLDMDRFKQVNDEL
GHAVGDGLLQEVARRLAAQVRRSDTVCRQGGDEFIVLMPEIAAADDAAVAARKLLDGAAA
PFVIDGHRLKMVFSLGISVYPRDGRDAETLMRNADTAMYRAKMDGGNRWRFHAAA
>A0A7L5X764|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MLHETEMENQSWLKKLARRLGPGYVVNLCFIVVLIFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKQLQYNVDKLLFLRNGMREALVAPLDFTSLRNAVTEFEQRRDEHAWQIELNR
RRTLPVNGVSDALVSEGDLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFMRSVPGRYYEFVTQPWFIGHSQRENRQRAVRWFTSQHDHNNVTEPQVTV
SVPVDSNNYWYGVLGMSIPVRSMQQFLQNAIDKNLDGEYQLYDSKLKLLTSSNPENPTED
LFDPRELASLAQAIEHDTRGGIRMNSRYVSWERLDHFDGVLVRIHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRQMVSNMFVLQSSLQWQAWHDTLTHLYNRGALFEKARPLA
KMCQTHKHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISRSLRPQYVAGRVGGEE
FCVILPGASLEQAKEVAEHIRLKLNEKEMLIAKSKTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDTP
>A0A2N7R763|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MTANARLAARDPLAALYNRRALEVRARRLLQDASPTHPGALLLIDIDNFKRVNDQNDHTA
GDRLLVALSEMIRAESPDEALTGLTTSG
>A0A3Q9E367|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MSNDADLMNELHWLIDMVQTIEVGLVVLDRNYNIALWNGFMENHSGVSPNSIKGKNLFDE
FPDLPAGWLKKKMESVYLLKNRAFISWEQRPYVFKFKNYRPITGRAEFMYQNVTLLPLAS
LTGQITHISIIVYDVTDVAVHRLQLKSVNEQLEHLSQTDGLTQLNNRRHWQMCMNREYER
FNRYGDPVSLVMFDIDRFKQVNDEHGHVAGDKVIQHIAHLLSQSLRETDCAGRYGGEEFA
VVLAGTSCEEALHFTERLREKVANSPIQFEGKKIQVTISLGICGMGDFIESASQWVANAD
NALYQAKQKGRNCSVIYSE
>A0A5C6EF72|diguanylate cyclase|EC 2.7.7.65|Rubripirellula reticaptiva|TrEMBL
MKKQISVLLVEDQQAEAIVVTRLLSHSAYGNFSVTVAVALADAIEQLGKNSFDACLLDLG
LPDGHGIESLRQVRSVDGCIPIVVLTGNDDENNGLTAIETGAQDYLAKDFVNSRTVSRAL
LFAIARQNTMLGHAADAQTDMLTGLPNRRLLSRDFDRMSNQFDLLSVALLDIDNFKTIND
LHGHLIGDRVLQHVASLVRDNAGNNIQAARFGGEEFTLLIPDSGIDATVDYASDLLSKIE
NATLEIDGKSISVTASIGLTSVRNEEGLDESLRRADQALYSAKHTGRNRVCVNDA
>A0A3S9LAA2|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MGSHAWSDKKRFIWVLTLLLISAFLATSGISYKVAHDSLIQQVEENTLPLTSDNIYSEIQ
QDLLTPIFISSLMAQDTFVREWTLNNEKDPERLIRYLREIQERYGTVTSFFVSEHSRNYY
HSSGVLKQIKDTEPSDSWYFRVRSLPEKEQYEINIDADTADRSKTTVFVNYKVFDFEGNF
IGITGVGLAVEKVKALIELYQKRYNRVVYFADREGRITLSGSGYYGGDSLQHTPGLDKLT
TRILTAPSGAFTYERAGKTVYLNSRLVPEFKWYLLVEQEEAPAERTLLGTFWINMALSLL
VVCGVLFIANMTLGRYQRRLEHMASVDKLTGAANRQVFEDVFEAALQKAKAGSTPISVVL
MDIDHFKHINDTHGHSMGDLVLKTVSNMLGRDLMEGELLCRWGGEEFLLMSPLDMVHASE
RAEQLRTRVAERQLRVNGHDIQVSISLGVAQFQYHESADQLIKRADMALYQAKEGGRNRV
VLSHP
>A0A7I6T3W7|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-CRE-02|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLIDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKIAAPDGSDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A645F441|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MAGTLRRKSSFLLLILDLDYFKRLNDTKGHPVGDLALKTIAHNLSTSVREYDIVARTGGD
EFTVVLADLHFSAEAQQVVERMKSSLDLKQFDLDVSIGVAEFPAEGRNYEELYRLADQRL
YVGKNTGKGKIIFN
>A0A645JN06|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MMDLDKFKSINDTYGHDTGDRVLVAFAELLTGTLRHEDAIARLGGDEFVALLPGIAKREA
TEIANRILRSAEAQSVSCGAKCDIPLVVSIGICDNASAASADAMLKAADQAMYQAKNGSG
NCCVEWSL
>A0A645CRM9|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLYAALTILLCSITVFSKDRYAFREYTTKLRLEQASSTDFLTNAATRARLEDEAHRWMSF
CRRQGLPLCLVFADVDNLKYINDHFGHTMGDVVLKQLAELMKKQLRNSDTIARWGGDEFV
ILLPNVSLETALLLLERVKLAVSQIDLHSGAVVSCSYGVVEMGPESTYQQMLSDADTQMY
RAKRAGKGQNAILHTPGSGTNAQ
>A0A645FRK7|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MALKALAKTLKGLYRSSDLIGRLGGDEFMILLTNVGSIKNLKRIVNDTVVKIAAMEYEQM
KAMALTCSIGVVLITDHSENFNTLYNQADIALYMAKWDGKNRYRIYSQRMDKELMLRVKN
ND
>A0A8E0FR29|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 97.0246|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>M1K6S6|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus Y19|TrEMBL
MEMYLKRMKNEWEALVENTQPHIRQLASEIAKAHAHTLSIEFYRDVLTDPHAEEFLSNEQ
VERQLKKALERWIISVLSCDVGDIDQLIKNQHTVAEVHARIGIPVELVEMGFRVLKKILY
PIIIDGHHDSVEKLQVYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFTLLENAEE
EKERQIGALLSWEMDIIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHNTNGSTKALNNKAARVKFLLQIRNSISQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDDILRRVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEANQTDTLRTAERIRSRVEKTKIKSPDGEIIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A0J1FN14|diguanylate cyclase|EC 2.7.7.65|Desulfosporosinus acididurans|TrEMBL
MVILRIMLCGFLLASGIFTLLVAIYSFRKRDPATNYFAVFSLSITFYSLGYAMELYSDTL
VRMRFWNFVEYIGLPFLPALWLVFTFEYNNKHIGLIEKLCIFMIPFMTFIFRVTNSLNHF
YYLSVKVTSNYYFPVLYIEKGPWYWVHALFVTSCFIVANYVYYAVYKKSIGPIRRQGAIL
LIASLLPWVTVVLDLLNLSPLDIDYGPFAVTSSVILFFIAFLRYHFLNIKPLARDKAFEL
TNDGIIVLDTNYNIIDFNPSAVVICNDLRENVIGKDVQVVLGRYKGLVYSILNEAESQCD
LEDPKGNYRVNTVRILEVNHRQVGYLVTLTDITKYVNMMQELNHLASRDALTGVYNRRYF
VELSSREIVKAKRYNHALSLIIIDLDYFKQINDTHGHQAGDLVLIEVVKCCRNSIRSIDI
FGRFGGEEFVILFPETNLGECNIIAGRILKNIENTIVSYENKHIKITASLGVTGTNFLYN
QSLDIFLKKADQALYQAKSEGRNCFRCLEL
>A0A087BN82|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium minimum|TrEMBL
MARSAGVPAVQGVPAAQGALMDGLRDMDARAASMTTIPIHGTSRSRNIQNAFRKLPAMGV
ILRSMSKTIEASIVVVDDEPSIRELLVASLHFSGFEVNAAGSGSEAIKVIESTHPDLIVM
DVMLPDIDGFTVTRRIRQGGVNAPVLFLTARDDTQDKVMGLTVGGDDYVTKPFSLEEVVA
RIRAILRRTQGQDEDDPIIRVGDLEINEDSHDVSRAGQPIDLSPTEYKLLRYLMDNEGRV
LSKAQILDHVWQYDWGGDAAIVESYISYLRKKVDGIVVTHEDGTTSRVDPLIETKRGIGY
MIRAPRRSSVQ
>A0A655PNN6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MANKESHPLSLAVIDLDHFKQVNDNYGHPAGDLVLQRVVALCQRHIAQVGTLCRWGGEEF
VVLLPHMTQQEAYQRMESIRAEIAMHASQPQVTVSIGVVQYQQNESLLHLFNRADQAMYT
AKSEGRNKVVGL
>A0A0W0U7L1|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MRLNCSKNLNLNAMKNFNQRVLLNLFLFILFFLQIGVNVSSYVQIQHLLNAKQWVLRTQE
LISAINDLWGNILEISVYTRGYVITGDANSVQALNHASATASTKVQSLKQLIKDNPKQLE
RLNHLSTLLKERIHFSNSVIAIYQKKGEEAAEDLLTKHRGTLLHELQTIIVSMINTEKSL
LNARDDELQKTSDTALSYIKMTNTLTFVLFFLFLGIFNIQFSRTVKLIQRRKQAEDQLKG
IISGTNDSIAAIDKNYNLIAFNPSYAQDFLQLFGKSISLGDNLNDLLQHLPSEQTNQINL
WEKALSNKKFSIIEELGDSKLTRNSYEITYSPIHNADNILIGASQIARNVTERLKIEKEM
ERANAQLTKNIEETKQRNHAVYLLNQLSSTLQMCLTVEEALEPIAIYGQKLLPNTAGSLY
LAHPSKNYMDCVTGWGKPAVEEQIIGTEQCWSIRRGQIYHYYNSEQSIPCQHVKAVKPIP
CYVCIPLQAQNENIGLLYLEFLNSQHLGEKEFQQLLETQYEQLIISIAESIALSLSNIKL
HASIKMRSIRDPLTNLYNRSYLEEFFARELQRAKRQNSKLASVIMDLDHFKKVNDTYGHE
AGDVVLIEVANLLTRNIRETDIVCRYGGEEILILLIEVNSAEEVYERIDQLRQEISKLEI
SFQGKLLEKITASFGIAMMPEHAETQSELIEFADRALYQAKKQGRNKVISYKK
>A0A377QNF6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MSARMSNKPARRPRPTLDSVLRRAHLSVSLIAVLAAGLTLTAVALLALRVYSDQNLRLVA
RSMSYTVEGAVVFGDSMAAKEALALIGVNEDIDQAQVSDTAGNVLARWERGEHGTRYYIE
RALTGWMLPDSLTFPITRNEQAIGSIKLVPHSRSLLPFLLSGLTCLLACLVLSLVVAVRL
SRSMETEITSPLRHLAETAHRVRRDRSFELRVPPANIAELNQINDDFNALLDELEAWQSH
LQKENASLSHRANHDSLTGLSNRAFMEAELERAILEARVGNGKVAVLFLDSDRFKYINDT
FGHASGDRVLVTIAARIKQQLREGDLVARLGGDEFAILLKPLRNSSDAMHIADNIIAAMA
QAIELPTGNSIVSSLTIGVAVFPDHAIDAVSLVGAADEAMYRAKQAQRGTRQVARLPQPH
THP
>A0A5M9IJ63|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MENRRGKGLSFARRIYQPRIIGLGVGSISVTGALYPLAMPGWVWALLLFNGFAWAHLAYQ
LSTRSPFPYQAEQRNFLYDSVLGGFWAAATQFTPLTAVTILSMMTMNNVAAGGRRLFLRG
LLAQGLGIGVAWALFGIQFNPDVSLLQVYSCLPMLTLYPMAIGMVCYQLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLHLKFHKCQQQQSHATIALIDIDHFKQINDTHGHIVGDT
VLRQLSLELRRNLRENDLAGRYGGDEFCVILPQMPLEQAAQIMEQMRETFGNYRTPHIPE
LRVSLSIGLADFQPRFTDAAMWLNAADRALYAAKDTGRNRVSVNDDRIACSA
>A0A336PYC2|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MIKKTIEIDTILLDLNQSIDAHYQWLVKMFRCTVSGDVNQPDIFDINSHCLCQFSQWLNN
HPVHEPEEKGFVIKIIIAHEHMHTRGRELLRAIAEKRSEDHHFDSFQEALLAFTSAVMDY
KIYLLNIRSNMDILTGLPGRRVLDESFDRQLIDAQPLNLYLLLFDIDRFKLVNDNYGHLV
GDSVLRTLASNLSVWTRYDETPYRYGGEEFVIIIRTKTDEQACRAGLRICQLVADNPINY
PDGELSITVTAGITQAQQGEPLDVVIGRADRAMYRGKQTGRNRCMFMDKDQQITRV
>A0A5E5R8N9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MHACPLPPDEALRQQALDDMALVDTPAEHYLDALVELARETFGVKTVLISLIDHDRQWFK
ARIGLDAEQTPRDLSFCGHAILASEPLMVTDASRDPRFHDNPLVTGPPFIRFYAGEPLHA
SNGQAIGTLCLIDPSPRLLDLREGRQLNRLSILAEGYLQLRSLTEHTRFLRQEIDREQRK
SLLDPLTQLWNRAGFHALHQHELELARASDQRIGIIYSDIDHFKRINDTLGHRAGDSVLR
EAASRLRAALRPEDLLARFGGEEFVAMVRVRETTELTMIANRIRELMEATPIDCAGTSVP
VTISAGCTLAGSGEEPERALARADAALYDAKRAGRNRVVSV
>A0A8G3P9Y8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSASELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A0A8VHA6|diguanylate cyclase|EC 2.7.7.65|Yersinia ruckeri|TrEMBL
MTHLESLSLIFNDACITYASLSISYFALSKNTPFSYHGQIWKRALFGLVAGLVSLHLNQD
KFVITTGFFYSFEVLPIVLATFYGGWVSTLIATVVNIAFTDGFTLDNLLILFIVLPLLFS
KVWTRKNNRVFYTTILLIMFYRLAVSAFFVDYKDLWPAIMVFQLSSTLCLAICYHALNFK
ERHIHAYFSMKDRANIDNLTRLNNRASVDFYLAQLHAQRRACGLLLMDLDKFKAINDNYG
HAIGDQILTSVGAILKQTVRCLDFVGRFGGEEFIVITESHHPEHIKKIAECLRENVEQLK
VTLNDGREMHVTISIGASLYLPGMSMLKAIEMADDALYQAKNQGRNQVVYSKLMPFSQLG
DRIRSTGKGYQRRHGD
>A0A8G6R9T9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVAVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>Q1Q4N6|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MKKEDILKDILKSPDLPTLPSVASEIISLTSKEETSVKEIAGMLSKDVSLSAKVLKIANS
AYYGFAYKISTIQQAISCIGINAIRSLVLSFSFLSIKGGNKAELFMYEDFLVKSLATAVV
ARLIKNKIDNNDLEEIFIAGLLKDIGKLIIASTHPELYDQVAKEAQNSKKNIIEIEQQII
GIDHAQIGYEITKNWCFPDILSVPIQYHHFPEKNKGDDKKAQLYTNVIYFSGLVSNILYS
NEPNKYYDTFIKEMKVNLGFSKAVIDDILDKVDLEVVHNANYFGFYIKKPKSIEEILIEA
NTILSGINLTYDQMNKELVNAKIQMQKAARELEIKNKWLESLANIDGLTEVYNHRYLQIF
LERELNRTKRKKGVFCLIMLDVDNFKKFNDNYGHQAGDFILKELCDLLKKGIRTYDILAR
YGGEEFAIVLPESDLEGALIVAERLRQRVAEHVFADNKEQYKVTISIGVAETKPSIDNLN
RSGLIGRADKALLESKKNGKNRITACLDKKK
>A0A2C9C9Z8|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MEKPKPVEDILLEANAALSVINLTYDQMNREHVATKIQLQKLARELETKNKSLQNLANID
GLTEVYNHRFLQAFIEKEINRSKRKQTNFRLVLIDVDNFKSFNGLYGHQTGDFILKELCK
LLTLCLREYDILARYGGEEFAIVLADTKVDAAVIVAERMREKVAKHTFIINNMKYNVTAS
FGIAEIAPHVDTLKRSDLTDNADKTLLESKKKGKNRVTVWRQKKKWFR
>A0A5H8RNW4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durham|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A730F973|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Rough O:-:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1S8RQ51|diguanylate cyclase|EC 2.7.7.65|Clostridium beijerinckii|TrEMBL
MQDYEKLYKSLKIEYETYQKFSEQHIQELNEKNVRLEKSIDSLSNIIEVSKYINTFFSSD
NLISLINDMILGILGVTYSTIFMIENGELIVKASNIENMNINLTSKEFVHINKGEEFLVN
SRKPLKQTGEHKIDIHSIMGSPIKLREKFIGYIVVEHNLYKFMNIELKLFLRSIANQIAI
AIENSLLYKELEKINQRDPLLGIYNRKYFFEFLEKKENRKLNDKFAIVMIDIDDFKKVND
TYGHQFGDKILVNTANIIKCGIDKNDIFARYGGEEFILYISDFTSEDNVYSKIEAIRRTI
EGSKINFNGRDESITASFGISFFPLNGTDLNELISKADDLLYKAKKSGKNRVLSGNIFKI
>A0A3S4I446|diguanylate cyclase|EC 2.7.7.65|Serratia rubidaea|TrEMBL
MKVKYLIYFFTFLLTASFTIAICDEWAEAKKQYNDSAWNLNKTLHSEEVSSVLQNTLRLH
TVKRLSLVNPELKPALWQESERETRNNIRQIRRYVNSGALQHLTTQQKIDIRSMLNLLEK
MLDNDTQQLAPMNNAIRNLFNINSAYYITQSSMDYYSYTYESRILNADAFLFLESIRLNN
QLNITLTEIIDQLVDITLNGQNDKESYLKTIQLTGVLNVLSSRLLFMEMVYSDPQISRII
NQLLEKLSPQQTDGLAGELYDSMVHGKAFDAARIYAYVKEMDRLSQQLFQRSFELEIAKC
RKQMYQSQTAINGLFAFAWLLALFLLMPTLIFCSNISRWLTKTQSNIQRLSHGDMAIDAP
EVFYSQELIAITDAINQLKQYHLEKVRLEQEKHALITELEASSYLDPLTNIYNRRRFFRD
AEQLPDASYPLAFCLIDIDNFKALNDTYGHNIGDLALVAFADLLRHAFRAEDIFCRYGGE
EFAILLHHCALPDARMALEKLRHKVQRLRLPVPDGQPVRYTISCGIAAVASPRQLQTAIK
LADEALYFCKKNGKDRVAINDGSSCR
>A0A0M3HDW7|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNKDFSQAPRPTFKNALRRISMISVVISMTLVWLLLSAASVITLKQYAQKNLELTAATMG
RSLEAALVFGDATAAEDTLATLGRQGQFSEATLLDSHQRHFADWRNDALVKNEKFSGYIS
KWLFPEPTVQPIWHQGKIIGELRLKALDRLISHFLGTSLIVLTGSILLASVIALMLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVIGKLMDDDAARHSSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGDQHQAWRLGGDEFAILLHDVHTETEVQALCATLSEQFLQPFNL
HNGHTATLSLSIGYALTWEHTSVEELQELADQNMYRMKNQRFHHTQK
>A0A3E1CB71|diguanylate cyclase|EC 2.7.7.65|Klebsiella michiganensis|TrEMBL
MNKDFSQAPRPTFKRALRRISMISVVISMTLVWLLLCTASIFTLKQYAQKNLELTAATMG
RSLEAALVFGDSAAAEDTLATLGRQGQFSQAILVDGRQRPFASWHNDGLVSQDKISDVIS
KWLFPKPTVQTILHQGKIIGELRLTALDRLISYFLGISIIVLTGSIFLASCIALLLTHSL
HRGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQRQLQAK
NAQLLRSSLHDPLTGLANRAAFRNVINDLMKDETAQSHSALLFLDGDNFKLINDNWGHAA
GDKVLIEVASRLMAFVGKQHQAWRLGGDEFAILLRDVHSETEVRALCSALSEQFIPPFNL
HNGHTASLSLSIGYALTWEHTSAENLQELADQNMYRMKHQRLQQTQK
>J2K2C9|diguanylate cyclase|EC 2.7.7.65|Streptomyces auratus AGR0001|TrEMBL
METESEPYVRLATLRQLHQVVAELNTARSLADTLQTVADGAITGLGFELAAVNLVRPDGD
LVVAAVAGSAGAEALMAGRVGSRAAWDRRLSMGERWGDLIFIPHTEGWVLDDDDVPQWHT
AGPAPRFPDEWHSMDRLFAPMYTAANGGGELLGVISVDRPRNGRRPGAWGQEALQMYAFQ
SAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAVAEMGGDQHGRLL
RTNDALCRLLGRPASGMRRYSFSDLVHPEDIGTLLRTSAEGGRAELRLARRDGTYVWVSL
RNSVVADTADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLGARLCS
RPPGSMADAYASLSGPGSDPHGFRTDGKEPFEGIDGFEGNAPAPFDHHVHLVAPADGPAD
DGSKGLAVLFCDLDGFKSINDRFGHNTGDAVLIEVARRLTSGVRDGDTVARLGGDEFVVL
ADGLGTADAQDLAVRLRNAIIPPIRVEGRAVRVGASFGIGWASCGMTAEEVLESADQRMY
VEKRSRSKTNRRAAG
>A0A7Z1EHB3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A7Z8DRD7|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A6A9U4D3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A7I7D8W0|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQREIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADHSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEKYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAAIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A0F1TI57|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MTAQTWRAHYEQKYQYSLRLFLLLNCVSAALSLLSPLFTIVTVTLPSSLICAASLGFLLW
NWKFPKQKINIPVISLLFGMLWAWHIVIKASLLPPPHFNFLVIALLSILFIGTIAFSNNI
IAFTLHSLPTFMVCLVLAGGEQWMRMFYCFVLPVAGITLQNIMQKRSDNFTQGLMDKLLQ
ERNTLNDLSMLDPLTGLYNRRGLQNRMDNILAVDTCEHFILLLDIDHFKAYNDNYGHMMG
DQALIQVSAAIRNSVRSRDIVARFGGEEFMVVLTSSSAESAFQTAERIRQRVYDLKIAHR
FNESVATHVTISIGMTPLVSGDIDSAIKRADSALYEAKNQGRNIILVN
>A0A380U998|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MREIRSEYLSQKLYIAMSIIILSLCSLSIPLMVKSYRDYIKTNQALTEIQALQAVADLAN
KISRERAPANKLMSSNQQDFAKHVLELKLYRLTVDEQMKKTLEVLKHSNLPNLDLSLVDR
LDEALTQGRQQVDAYAALPREQRNAETMDQAILKMFNAWDRSHDVLKDVIAVSEGKDTAV
SNFYVQILLLADLRDQAGRAASNVMAHVAFKQPIPETNLARSLQTRKQVMYLWELIDTLQ
PERDKTEEFKVLHQAVYNEFLAKGLLIVERLMNESIYHRPYYLTGTQLTEAIVDKFSTVV
ELQNYLLKYSVEKAIIEKHKAQNILLTTVGISLISIFAALFTMIYARKRVFSPLIQAREI
LFDLSHSSIRPNPMDTKDQPANVYSLFTAIQQLKQTLQQRDALEFRLKNIAHLDSLTGVA
NRYALNEYIKLLENQPTQFSETCLMVIDIDHFKQVNDVYGHLMGDQVIQFVAEKLKENIR
TSDLLVRYGGDEFIVLIENVGMERALKIAEKIRSEIYEAKSVDHVRCPDLKVSISIGVAI
GATTWMALLEKADRALFQAKEQGKNKVVAYSVDEVNESYYI
>A0A5M3VA88|diguanylate cyclase|EC 2.7.7.65|Enterobacter ludwigii|TrEMBL
MQRETFVVRRSFLQWLHMRSNPGLIVNLCFLIVLIFSTLLTWREVVVLEDAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRKSMRDAIQTPLAFDVLYEAISRFNAFRTRPSWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDPERISNEISAALEVGYLLRLASSVGQSEERVIYASRA
GFYLATDTPEQTSDISQRYYYLVTQPWFTQQSERNNRARAVRWFISSPSPWTGGERMITA
SVPIYFDHYWYGVVAMDFSLKTMKHLLEEATQERTEGEYQLYDTRLNMIATSEETGSLVN
RFDERETAQIAHAIENDTGGGIRLGSRFISWERLDHFDGVILRVHTLHEGVKGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKMLS
EKCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGLIGSALRKNDVAGRVGGEE
FCVVLPGSGLEEARGIAERIRSRINSKEILVKKSTTVRISASLGVSSAQEKDNYDFEQLQ
SVADARLYQAKQCGRNRVFWHDQDKK
>A0A212IE39|diguanylate cyclase|EC 2.7.7.65|uncultured Citrobacter sp|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQNVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A6C8YGI4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAEETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRVERSLN
>A0A5H7MSN4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Reading|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0K2DYL0|diguanylate cyclase|EC 2.7.7.65|Piscirickettsia salmonis|TrEMBL
MSQNIFTIIKPSLETQLLIYQTLYHQPNNQFNLVNAFANFYQLICHIIPCASVTYENQED
HIYLQQGTAGKYNYSVLLKHQNQPLGQLTFSHSLPFSLGTGLELDALCSLWLTPLFHILQ
YHSALQATRQDHLTQTGNRAAYEKILDQEINYAKRHDSPLSMLLIDIDHFKRINDQHGHH
QGDLVLQHFSHLLKELVRDSDMIFRYGGEEFIVLLRNTDLAGANLLAKRICESVYHTLTF
KIDISVTVSIGSCEFDHYDIDRQFFQRADQALYHAKHQGRNCVASYSIFDTSPKLLSTLS
KTSQSIS
>A0A5H6F710|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Alachua|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3U5WBH2|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVIVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A5I6I090|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Hull|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A0D5YKM9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MPYSLREFSFSTSLKFFLLFTIIITLCCFIGIASRPLSFLAFFWPANSVFLGLLLRFPQT
RQIVSFAGAFTGYMVADLVNGTPLFLTLILTISNYLYVVTTLALAILFNRHIKAAYQGYS
YLLLFALCGIGSITGAFFAATFVPMFNTKFMIGSFWAEFGYWVTSELQNALLLLPIILNI
PPYLKIKTHLKGNRIYIKAIDFLPLFAVLISIGVSYYDSGPGSLLYPIAALIWCAIRYKP
IIVALITSFTSAYIIYHVSGHYLLLYPQDYLSNNISIRIGLIMMTVAPLTVSSISALHSE
LIQKLQHAIAHDELTSSLTRRQFLQSVRLLQEKVQKENKTSAFFMLDVDHFKKVNDSYGH
LIGDRALQTCVTTIQNILHPHDLLGRFGGEEFAIFIPDTTREAAFELAERIRIQISQQPI
YVYGKLPIFVQVSIGISLYSPSYHRSIESLFKEADDALYQAKRQGRNRVFISL
>A0A3T5DF86|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDSPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A630UVW3|diguanylate cyclase|EC 2.7.7.65|Salmonella derby|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3R0GIM4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A332BBV6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLTKFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITIALLILNALI
WPSVAYLASMMSKDMLSTEKKNMVLDSFWAGIWIAVMQASPIPSLFIISVQIADRYAAGG
WKILKPALTWMMISFVIVWLANDFRYTIEFSTRTVLLSLPLATCYPIVLSVVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSKLVIAMVDIIQEKIKDL
SLPSHKDMYCTVSIGISCAENKESIIEWIKEADQMLYEVKRNGKNGYCMPNN
>A0A5D6T3T7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQTYPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A5H3VUX6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kentucky|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4V4FW98|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIANELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQPLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A1B2JPV7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPVTRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKHQKVIATWRYNAQDTTEKISGLIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISRFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGNRHSPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFDRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKNLRSERTIIK
>A0A8B3V4H2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MTSQSWLSLVNKKYQLSLRLFLFLNAASALFSVTNPLYSVRVLSVPLFAVLTISTGLLIW
HWKNSTRKINIPIVSAIFGLLWAWQIVSKFLLITHDHATYLMMALLTVLFIGSLAFASNI
KAFTLHSFPAFISCLWLSPSENWLRMAYFFALPVVAIGIHHVLQRRNDRFAQELLSELLE
ERETLTDLSMMDPLTGLYNRRGLQSRLENLPRPDAGEHFVLLMDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVARFGGEEFMVLLSNIPLEQARQTAERIRQKVYDLKIPHM
FNESVATNVTISIGIAMFEGEDVEGALAKADKALYEAKHMGRNSILLSEELHTA
>A0A241QCK0|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MKLHHKALRLFISVSVIVLTSSFLVYELIASDKAMNAYMRYINEKADSSFLYDKYTNQSI
AAHLMRTFSSPQEPASLEQQKALCTAFDSVNGAHGLNLTKHNYLPLHGTLQTTSTKCSEQ
LDDIFLLPSFDRAVNVNRQQKDYGQGLGTLEYKFRYYVDLKNNYVYFYDLIDSRKFAIHN
WSFLQKGTLGIDQNDIDGIFTGRTVISSIYEDNLTEKKVMSFLTPVYYTGKLKGVVMVDI
NKENLQNIFYTSDRPLVWRYLNVTVSDTSSGKEILVHKSETDLFRYVDYEKDIPGGIRIT
LSLDVMYFIVSSWKIFAFYLLATILLLNMVRTHFRLYHNVTRENVSDAMTGLYNRKILTP
ALEQRLQQLVNTGTLVTFIAIDCDKLKVINDTLGHKEGDRIITHLAKAIQSSIRKSDYAI
RLGGDEFCIILIDHPSDLTPRLLERIRYNLQIIAHDISISFSAGVYNMQPNDTIDDAYKA
SDAQLYLNKQKKHAGA
>A0A3V7IUQ2|diguanylate cyclase|EC 2.7.7.65|Salmonella rubislaw|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3Y5ZD54|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2U0N9W5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVVFFSTLLIWREINDLEEAYVANQRNNLSNVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A2L1BXZ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A2L2LAL8|diguanylate cyclase|EC 2.7.7.65|Rhizobium radiobacter|TrEMBL
MTARVLVVDDIPANVKLLEARLLAEYFDVVTAEDGFKALAICDEEQVDIILLDIMMPGMD
GFEVCERLKANPNTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLIARVKSLV
RLKAVSDELRLRAETARQIGIEEMLRSDGLMQTPGRVLVADGRASSQERIVRALKPVAEV
DAVTEPQAALLKAAGNPFELVIVNSNFENYDPLRLCSQLRSLERTRFLPLLLVAEQGADD
MVARALDLGVNDYILRPIDPNELVARSLTQIRRKRYNEHLRLNLQHTMELAIVDGLTGLN
NRRYLDNHLKILFDRAAVRGRPISICMTDIDRFKLVNDTYGHDVGDEVLREFAARIRSTV
RGADLACRYGGEEFVVVMPDTPMELAASVAERLRAIVEDKPFYVRSIDRELSITASLGIA
TSSGAFGAPDEILKQADKALYEAKHAGRNRVVAAAA
>A0A3V3G1M4|diguanylate cyclase|EC 2.7.7.65|Salmonella thompson|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5W2RRH8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Corvallis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A753EHU2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 45:g,z51:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A3L3W4B8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMGTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A0B1K0I1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQD
FDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLL
NRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNV
RSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAM
FNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A853SSA2|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MIAITRPLQRLARRLYRLSLVPLFALILLLALWAAVLYQVGQERAGAVRDAVAVSQSLAR
TLADHTSFTLRQTDHATQLFKLKYEETDGALRLNEFTRRQGLLDSVLPSKLELPIALVDA
RGDVIDSANAYLPENLAGQAFFKALAANASDTALVDTPMLDAGSKHWTIRLARRLNDGQG
RFAGAIVIHVDPTYFVDDYDRLNLDEHGALMLVARDSGLTVGRIGEQLILSDRIDFRMPG
PPQHAPEELLIEPPVDATARIYSYRELPRYPLLAVVGVSHAVALTRFEHRRLAYIGALLA
ASVLIAGFTALLMRQSARLRRSIRQAKETQALLRAAHQASLDAVLLLKAWRPAPGKPVED
FTFADINERAADMLGKPRSELLGQRVLPRVPLLRGERFFKRFVLVMETGQPLEDEFELKL
ASGGTRWLRHQVVPIADGVAVTSRDISARKHDELALQDNRSFLQSLIDHLPVLVYVKSAR
PENFGRMEVWNKAAEDITGHLAADVIGKTDCQAFPPDFGLHDAEDDRAILAEHGVIDHTE
KPLRLRDGSLRYLRSVSVPVFDERHQVEHILCIAEDISQRRQQELELRQKQAELAAVNDA
SPLGLVRLDRQRRCTYVNRTFEAITGLPRAAALGAGWTSALHPDDYPLMHVALEQLTRSH
APFQSTLRCLQRDGRLVWVSVKIAPILIDGQIDGYVGSLDDITTLRESEVALLESEARLR
TIADTLPAMIAYIDADQVYRFLNIAYEREFGLTGRQALGKSVRDTVGEARYGTVAPYIER
VLAGETLSFEEEDEKEGIERCMEVIYIPQIGEDRLQVVGFHVMRQDITVQKREKQRLLKL
SQVDALTGLSNRAGFQQKLSDAMHASRRQQHLMAVMYMDIDRFKPVNDTHGHGTGDALLR
AFAQRLTQTMRATDIIARLGGDEFTIIMEQIARPDDAAVLAEKIVAAMRQPFELDGITVR
ISASIGLAFYRDEDISPAVLLQRADVLLYQAKQDGRNTYRAGALTT
>A0A827PXN2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPIPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A2U2VP48|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLEFSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAISLDEQRRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A827LEG8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTAPHDPLTGLANRAAFRNCINTLMSDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKRHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQASMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A1X9TJV4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHKGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIAHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2I6ICD1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A853STU9|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. HH102|TrEMBL
MFTSRSLSPAFYYLFFSGEREQQQRFFKELHFISIAILTFGLACWLVTFSLTLSRASLDH
AQAALGVTGMLAGLLLTVYAKSLQAIITSGTISVLFIAFGFRVLMLGTEDPAFWVLPLGV
MITLTTAPIFSGIAYYLGVSLCVWAILGLGQFPVHAGQADQHWPVLAVTISVIIGLALNI
YFLVLRIHNYRAQRELATMAYKDGLTGLNNRRMFTQSARALQRTARTPAYFLMIDIDDFK
QINDVHGHDVGDEVLKRIAEVIAGLSGEHLCGRLGGEEFAVIYVGEKNAACAFAAQLVDA
VEAAFVPERKVSVSIGMAELIKEADLSHSYRRADESLYQAKKNGKNRYVFNAA
>A0A378BM17|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLAALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A377E971|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPRDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRTERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMRGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWNCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAVSVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H0GUP6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVHVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0L7AEE2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADIPSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHSALHS
>A0A024L2T3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMYIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A244BAU1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A828PNS4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIVQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLQHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTITHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2A6Q318|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A0K3ND34|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECPTVERL
KMLVDERLYKSKKNGRAQISWQ
>A0A2X1N9T6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A3L4BLX8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A376DJE1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISSLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A5I4XAK9|diguanylate cyclase|EC 2.7.7.65|Salmonella muenster|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A0B0VM15|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A3L2NUI8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYGSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5P9HIQ5|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MTLRGRLLVGAAMLWGVLCVTLLTLGWQAGRILVDETNHQHLRYEAELISNSITYQVDER
LDELEQLAKQIPEPVRGALDAQHGHSLSPLFEGLTLFDRDTRVVDAWPIGDGRVGASFPD
REYARFMHAFRRPYVSEPFVGRITGSPLVMMLVPLRDGAGRYTGFLGGLVNINESRLFKS
FERLRLGDGGYVTITTASGKRLFHPDQEQPIVALPEQLSPVLERALYGWEGESAGKAVTG
EAQLVAYRQIWPAGWIVGVHLPQSQAEAPLVAGMQRISFHAWGALVLVLPLVGGLIWLTL
RPLTRLAEQVRELQNERRYLLEIPTHMPELRRVIDVINETERERRGNLQDLAEREALLRG
TLAASPQGMFVTDSRGQVTFINAALEELLGGDESLDMDTWGKRIHAEDRPAVIEAWHQSL
AGRCDFMRQFRLLGAEGIPRWLDVHAGAIHVEGEFIGIVGMVRDITQDRHENALRRWETE
HDPLTGLLNRRGLTRYLEEALVEWQKTGTPTAVLLFDLDHFKPVNDQGGHALGDRMLQQV
ADAVRSVVRSSDHAARQGGDEFAVLLSGCSPDQALVLAEALREQIGSCPVEQGDKRWYVT
ASIGVSHFQSGEESIKAVLDRADAASYRAKRGGRDRVILDSEEPAMTDLDESTGKVG
>A0A265B698|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A161UWT2|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MSNDQSAMNELHWLIDMVQTIEVGLVVLDRHYNIQLWNGFMENHSGVSPNSIKGQNLFTR
FPDLPATWLKQKMESVFMLKNRAFISWEQRPYVFQFKNYRPITGRADYMYQNVTLLPLAS
LTGQVTHISVIIYDVTDIAINKLQLKAANEQLERLSQTDGLTQLHNRRHWQECLDHEYDI
YARYSGMASLVMIDIDNFKHINDSYGHVAGDKVIQHIAHLLSQSLRETDCAGRYGGEEFA
VVLPKTSGADAMYFTERLREKIAASVILYESLKISVTVSLGVCEIGSHITSSSSWISCSD
KALYEAKQKGRNCSVLHTSTSVNKTTQD
>A0A0D6XTW4|diguanylate cyclase|EC 2.7.7.65|Staphylococcus microti|TrEMBL
MIEAIIYNISVTIAGIYLFHRLQYAESHDFRFSKSYITVLMTIVGLLLTFYPVPIAGYAI
QLSFVPLLFLGRYTNGFYTFISAIIIALVGYFVLAMSLVFAIALIIIGAIASTIGPFIKY
NHIIAMQILNIISIIILLIIAWFVPNYDVLAVLYLLPLSIVATFVTAVFYVDVHHFFRLI
ERYENEDTIDYLTGLGNVKEFDRHLNEVSNQAQQQAQSLGLLLIDIDGFKDVNDAYTHSA
GDAVLKQMAHLLENYVPKQTQIFRNGGEEFSVVLRDYTLDECVKLAESIRVAVSKSSFHL
PDKIVIKLSVSIGVGYLTDDDYKSQRKVFKDADDMLHVAKNEGRNKVMFNPIIKLQ
>A0A379QWI7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A748B9A5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRLLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6A9RDX9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MSRPYSPRFSHFLAPLALLLGGEAIARQVVLNEFFTSLYNVLPTVLLLLGGALCAMYGRI
RELFLLLCVYIVYFLLDTHADYYRAHGRLLDDAALTFHLCSLLLPLLYGLYGLWRERSHL
AQDGLARAAVLFALGVVAVALAKRFPEALHAWLVVIRWPSLQADWLPLIQLAYPAFIVAL
ALLVVQYLRQPRPSHAAQIVALIALLLMLPQTFSRIAALNILSSHVLLMLVVAIAHEAYL
MAFRDELTGLPGRRALNERLQRLGRQYVLAMADVDHFKSFNDTHGHDVGDQVLKMVASRL
RKVGGGGRAYRYGGEEFTLVFPGRSVEQCLPHLEAVRQAIEGYALQLRDASKRPKDDRQG
RMARGHSSTAQVSVTISIGVAERQGDQRSPEEVIKAADQALYGAKKAGRNCVRVHGSGRG
AVRMAGHSR
>A0A5U5HY07|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0H4W2V4|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MRRLDLRRLTLGLSILSLLLALAGALYASTVVQREILLSSSLEDNRAFAQKLARGADIFL
RECLNELSYSARLIGSDGASEQSVRREVERLKHQSGRFNAAAFINAEGVIADIVPAEPGV
IGRRISTTEMEQALASRLPRISDPFLSPGGRWIIALSQPVFLPDGRFGGFVLGLLFLHER
NALGEMLGEQIHRNGSYQYVVDRRGVLLFHPNLRRVGQIVEQNPAVRAIMNGEEGARRLV
NTDGVDMLSGYALVRETGWGVVAQRPVDSVLSRSKVLLLRTLQTSLPWLCLSLLCVWWLA
NRIARPLAQLASAAADLDKPRVGDRLSAVGAWYREAEQLKAALAAVSRKIGTKFNQLRQD
SLTDALTGLLNRRGLDEILQSEPRYGRAMAVLAVDIDHFKSINDELGHAAGDAVIRGIAA
LLRSRARASDILGRLGGEEFVVLLPNTERPQALQAAERIRSAVESFQAVPGGACTVSVGV
AVYPHEGASLTEVLARADEALYEAKRGGRNRVCDAANIAA
>A0A0H4WLW9|diguanylate cyclase|EC 2.7.7.65|Bordetella hinzii|TrEMBL
MAAKSDLDRRIADLLADPAYEGHPLRAALETLWLQANEHMARIERITQISDAYQSMALRR
EQGLYERFDRQLQRLARIARISDHYQSMMRDLNRTLEETSRRDPLTGLLNRRALMDIIRL
EVQRSDASGKAFLVAMLDVDHFKSVNDRYGHEAGDRVLVELAGVLQQSMRASDHCGRWGG
EEFLLLLPETDLAAGQLAMDRVVGAVRALSIAVGGETLRLTVSVGMADHLVGETLSDTLS
RADQALYLAKHDGRDRVALPGVPRQQAAGD
>A0A1E3A6R4|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MKEKWDLNSQKLGILLRNFADMIWEYDTETHRLFAEPECAKRCGLPEIVADGARGLVDAG
VLHPDYLPSLSHLFHSLEIQDCTLTAELLARSGISHDYNWYRVVFTSFVDSESGRLQAIG
FFQDIDYEVQQRLKLQHLANMDCHTGIYNAAAGRQLIQNKLMQQSPSTHNAMFVFDIDNF
KLINDTYGHYRGDEILHHFADILRCVCRKTDTVFRIGGDEFGLFAYNTDDEKLVRRICTE
ILCRTNELSEDCIPVSVSIGVAVNKEYAPSYFDYYRAADKAMYLAKENGKGNYRADYF
>A0A377RVP6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MWTKPVLRMNLRRLIVLVAFASALVSLANTFYASYSVQRQLLIDTTLEANHAYASKLAST
AEDFLQSARQQLAYSAGSLPSRMGDDGWLTDEAQRLRLQTNSFNSVLIVNADGKVLGVSP
ETLALKNRTLDSVGAVQALRERRPLVTQPYVSSAGNLVVFISHPIIGKDDRYLGYVGGSI
YLKQKNILYTMLGQHYYRDGSYLYVVDQNRRLLYHPDPERLGDLAGKNDVIDTIVAQQGG
GNRRMSNSLGVDMLAGYAVMPSTGWGIVAQRPTAMTLAPLNQLMANTVWHSLPIALLSLP
FIWWLASLISRPLMQLADGARRMDAPGTAEHIAGIRAWYVEAAQIKKALLKGLALLQNKI
GKLKTDVQTDPLTGLSNRRGMAAALDVWQAQARPFSVIAIDIDHFKQVNDQWGHAVGDDV
ILRLAQLMRACSRDADVLCRTGGDEFIMLLPDADLDAALQVAERLRARVAAAVIPGAGAI
TVSLGVVSSEQEAGNTDAVLLAADAALYVAKENGRNCVGITEPA
>A0A653UVB9|diguanylate cyclase|EC 2.7.7.65|Nocardioides sp. AX2bis|TrEMBL
MRLPRPARGTRVARVLRLAAILAVLTAELVFVVRVYHLDDPVEDRRVALARVQALLPEAP
RDGLDETAAARLGAAADGLVASGAPGADEVVDAVPAAVAGAPGAAAALREALDVTGQGVE
DQRAAADRAVLALLLGLFVVVCVGWFTWFRRLARRHRAVQQALTAIEVTARGERRLEALV
RNSTDVVAVLDADSTATYVSPSTLQVLGLEPEEVRGRRFVDLVDAEDRPLLARALARQED
HDLLTLRAVHAGGRPLVLEATVKDLHQEPSVGGWVLTVRDVTDRRRLEESLTHQAFHDAL
TGLANRQLFTDRLDHALQRRESVGGELSVLFLDIDDFKVVNDSLGHQAGDELLVAAAQRM
GAAFRPQDTVARLGGDEFAVLLDDTDLDAAGDAARLVLETLDGTFVVGGRRHRLQASVGL
AGTATGARTSRELMRNADVAMYHAKSQGKGCLALYDESLHARAMELLALRGELAEAIPGG
QLLLHFQPTVALESQSVTGFEALVRWQHPERGLLMPDDFIPVAEQSGLVVPLGAWVLAEA
CRAGAALDREGGPLFMAVNVAAQQLTHPAFHDTVVDALAASGLPAERLVLEVTETVILDD
VERGVATLAALRGLGVRVAIDDFGTGYNSLSNLAVLPVDVLKVDRSFVQRLGGSEDASSL
VEAILAMSDALRLETVAEGVELAQQATWLREHRAVMAQGFLWSRPVALEEARSILVAGVP
RTGGADPAGSAAGQETTVEAVVAAVEISRLDTGSSAPTSLPG
>A0A120JW27|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MTFGDGVVPSSAYQALLDKVSELEKAERVQRALYAISELSGAQLEMSVMLSRLHGIISEL
MYADNFFIARYDQDSQHVRFLYFADVATPFSDVTAAGMEAPIPLDEIEYSLTWYTIRLGK
PLRGTLDKIGAELPGEFRPLGVAPKDWLGVPMLEGSQVHGILVVQHYEEAEVYGPEDQAL
LSFVASHILTTLQRREYRENLERAVALRTRELADANAKLLQEIAERKRNELIQRALYHIA
EQAGDTGREKDFYRTIHYQLGSLLYADNFFIALLVDDGEAIDFAYYANDYDPPSPKRRLR
DGLTEHVLRLGADVLLDKRQIAALEAEGSITIKGRRPHSWLGVPLRCEGRVLGVMAVQSY
RDDTLFQPKDSELLRFVSSQIASSLERKRALASLREAKATLELRVRERTWELEKEIATRK
TVEQQLKHEVMHDHLTGLPNRAHLLERLEQLPKRHEAGGERSGFAIMFLDVDSFKAINDE
HGHIMGDMVLREIAERLKQSVRPPGLAARLSGDEFAILLEGIEHAEEAVTVATRFLRALE
HPVSLAGISLNVSVSIGIAMLDEHEMTHSDVLGRADKAMYQAKSEGRSLYRLYSSSSESS
PGER
>A0A0P0JDT9|diguanylate cyclase|EC 2.7.7.65|Blastochloris viridis|TrEMBL
MPSSCRLDRVVQIAKRHRAQLTSRRQTGGLMPCSITFTVMTVLLTLVFGELIWHDHASCR
HRPSVTMSRFSPLCAMTLLTASGRWRFWNHDRSDVVRLPEFGAVVPFAGTHRMRSIMAAF
LSTQLDFIFFFYGLAFILLGATCFAIAGGAKQREPWTVLGLFASVHGASEWLDLTALVIG
DTPVFEVARIAIMTGSFVFLTEFFRHEAIQFGLKLPGRWIYIPILLGIAAGGFASGLPTA
GALARYSFGFVGAMGTSWVFVRHAGTFSGTTKRLAIFTAIGFALYAVAAGLIVPAASLWP
ARVFNHTWFIQTTGVPIQLVRGLLACWVSFSIWAIWGQKLIAEVSSPNYTLYLRKQFMIT
LVSMAIILVSGWVLTEFLGGIYKRNVQEEARVDIDLLASRLASETATVEAITKMLAGSPA
VVSLLASGSLQGKERVKSVVDLSVEASGAEFGMILDGSGTIVASSGSVPTARSSAPTYSS
AAYFQASIAGDAGYHFTFDAAGRVCNYYASYPVRGERGTPIGVAVIKKNLGAFEADLKLL
DRPSFFIDPDGIVMATNHPNMLLRTLWPLSAGRLAELTRQIGAAIDDRPLLEREIEDSTW
TVFGGEREYVRRRYANHSQWSLVILKPTRELFANRVFGIVVTLLITIIVLIYLFSRERWI
RDEVQLDRRLKLQQLANDLRFQATTDTLTGLSNRLKFNEALAYETSMSNRYKMPLSLVMF
DIDRFKAINDTYGHQIGDKILIQMSRFILSNIRSVDLLARWGGEEFIILMPGSDGHMAYQ
AAEKLRDAIDREAFDEAGTVTCSFGVTQYVIGESADAFITRADNALYRAKVDGRNQVVLA
LQAVGATSEIASVA
>A0A8G3DKX6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFLPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGIAALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>T0R2C0|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MSKDSFAQSAAYLKQAVPLMIKYQIPTTPDNYTLWYNYVSASMPELNQAIDQAIKLQGTC
SLTTCERLYHQHLAAQDEQQMEAMKLSLAAMANELGHTMQDAISDTGMFQEMLDKSFDRL
SLIDDEGLSLDDTMGILRDLVRESRDVRMSTMHFRNQLSNAEKEIKELREALNETRKLAN
EDALTSLLNRRAFDLEIDGLIRSKQTFSLILSDIDRFKNFNDEYGHLLGDQVLRAFSKRL
RETCKEGVTAYRLGGEEFALLVPMRNLALSRQMAESLRRAIEKMSILDRKSGRRIDHITA
SFGVGEYNGQETGDALVERTDKLLYKAKELGRNRVMPLPS
>T0PG23|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida subsp. pectinolytica 34mel|TrEMBL
MDILHTPIWVYDIRHHHIYWANRTALGVWEASSLAELQARDFSADMAAAIDLLLQRYLGD
FQQGRSYSEWWTLSPKGIKKQIYLRLSGIQLAGRLMMMTEAVIDADTLYQESSLATGDTL
ACLFDNQGQLESGNHHFDTCFGDQVSQLSQVFSGNNEAFYQKLSRLDEVVAEGECRTRKG
MRWFQYQFRHIQQGAQILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEAYC
GMGGRFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQVCPRDVELARLGGDEFTAL
VPLAHSSDRAQEVADLMLSQMTKPLQLSGVPEVTIGGSIGIAIYPDDADDGDTLITRADM
AMYQAKQMGRLRWQRFTPSMQQTLHRKLTLKQFLAKAIGRQELSLCYQPQVDVAQGKLIG
FEALLRWHNPVLGHVSPVEFIPLAEEMGLIREIGSWVLSTALAQMAHWQQACQVRVPVSV
NLSGFQLSTSLPELVAQQLKAYGVDASLLTLELTETVLMLDMKGCIEILDGLSEQGIKIA
IDDFGTGYSSLAYLNRLPIDTIKLDRSFVVGLNLPVIRATVAMATSLGLGIMAEGVEDEH
ELAALRAQGCHVFQGFLFSKPMTVAQVEENRFAVCCKAGTYPLAE
>A0A0D0HQI6|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus ayderensis|TrEMBL
MNIQEHDQYAIFKQKFFDWFLTEEDFTNLPRIIQALITLLQKEFHLLDVTFYVLNPFKHA
FEPEVTTNHIIEQQQEKYMIPFDDQLKQQFDDVVVIDDESEIKTVQFGIHFSEDSLGLIR
FQLHVRDMIPRSLIKQMRQDFLKVFARIRKVSEVLSEEKRYEQLHRAATKIHASMNIGDV
LEEIVKTLKEVYPTFTFHLFLSYDSTTDRDLPIKLLTFENEDEHMGAMQAYVTGQIQLHD
SLVHKKSVIYAPIKGAQGIYGVIEMIAPTIMELPEREMRFISLLANTAGSALENAKLYEQ
SKRLIADLQLINETIHHLNTNLRFQDALQFMIEKIKTSFDAEEVGFIILQEKERKVLPGS
TAFFQSREAKAYVDFVFHRIQHPRDNLFLGDVKIHSDHAKRFRSLMAVPMMRGMMKGVAI
VLHQEAYHFSFDMFKLLQSLIHHSTLAFTNAALREELERMVITDRLTNLYARHYLDERIQ
RSMEEDGLGTFILIDIDNFKKINDTYGHQVGDEIIIQVANIIKANIRQNDIGARWGGEEL
AIYLPKVSINAGLSIANRLVQKVRELTSPPVTISCGVSYWKKNRADSVKELFNRADEALY
TAKRTGKNRVVVQEY
>A0A157QRI3|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MKQDTADLERRVSSLLADPEYAGHPLHGALSDLWQHTSDVLERVERITHLSDAFQSMARE
RELDICRRFDRQLRKLSRIVRISDHYQNMMRELNAALKNASIHDELTGLANRRALIEVLK
EETERAARHSRRFVLVMLDVDHFKQINDQHGHDVGDRALIGVAGLLHDGLRQYDACGRWG
GDEFLLLLPESGLEDAKAMLERLVCQVRELRVLAPSGEIGLTVSVGMAQYRPGEAFNDTL
TRADHALYSAKQQGRDRVAADGPGPLPVDPNASPAE
>A0A157MEK7|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPASGSSQDAATSGAPDLFKSENDALDKARSAFDNQDASGQEYRQSLGELIGHFERLMRE
TRRLIGRSDRAEREMNALNIQLQTLAQQLEYRATHDALTGVFNRSAVIELATKALAEGDS
VMVVLDIDYFKRINDEFGHPAGDSVILGIVTCLRRIVGDEGIIGRVGGEEFTVVLPGYQL
QQAVELAEAMRAAIAEHRFEPPVDRQITASFGLSANAGGTDFDAAYGLADEALYAAKRKG
RNCVEIAQPLSGAVT
>A0A2I8Q350|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium ENNIH1|TrEMBL
MSCFPAKDESFAKRHSHLKRPACPGVFLLSVICRWQSHNAFSVAFIQGVFVGQEKVIKSP
PRLAFVKNWFVPSRVVNLCFVIVLVCSTVLTWREVIVMKSAYIASQRNALDNVANVLDRQ
MQVGINRLLFFRNGMQSALQTPLAFDVLRNIQAEFEQKRIQPYWQIVLDNRRTLPLYGVS
DYFVEQSASLSRDNPLLHNELTAAMELGYLFRFSSSATVFPRRALYVSRAGFFISTLPVG
NNNDIVQKYYQYLTSPWFTGQSERENKLRGVRWFSDEAHELSLADSLVTASVPLDYQNDW
YGVLSMSFPVSSMKALLTEARQNQDRGEYQLYDAQFALLTTTAERGSAYQQFSGEERAQL
KREMAKDTSGGLRLGTRFVSWEKLKHFEGSVLRIQTLREGLRGDFGSISLALALLWLLFT
TLLLLSWGVIRQMVSNMFQLQHTLQWQAWYDPLTRLNNRGALFERARVLTKECAAQNLPL
SVIQIDLDHFKRVNDRFGHQAGDLVLSYAAGLIGKSIREQDVAGRVGGEEFCVLLPGATL
LDATVVAEKIRQRISGKEIFVQKSKTIRITASLGVSGAQESGNYDFEYLQSVADSRLYQA
KNNGRNQVCAEDGVSPLPNT
>A0A7W4F8X5|diguanylate cyclase|EC 2.7.7.65|Serratia sp. OS31|TrEMBL
MDISAPNHLITRQGALLTHSLLAALTVFLLALLCLTLSNESSHFTPLWFPTAAIIAVLFR
HSPRQWGLPLLACGIGIVTASVTLFGFSWFPVKLTLINLLEAVVCTLLLRRMLLTDDPLN
SLASWLKFVVCAVIFTPLFSALLAAWWVPAPGHTFWHPFSTWFISEAIGVLSLTPIGLVY
RRRMLDTLNLYTLLLTLIVALTFSYLALSYLPFPFTFVILPLLWAAIALPRLEAFVICFC
TTLMITVMISVGLLHFHAPLGPFSDIEIYLPILLILIPAHSMAMVMHAFRVEKQHIVESE
TRFRNALEYSAIGMALVSPQGKWLQVNQALCKLLDYTPEALRRLTFQEITHPDDLNADLT
QLRDLLDGHISSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKRTA
AENHRLMERITLANKVGGIGVWEWMMHGEELTWDKRMFELYDVSPEQTPTLSLWRTLLLP
EDRERTDREMSVLLQQPGPFIMEFRLLTREGKVRHIRGQGNVILDPQGTPLRMIGTNIDM
TEVRNLTEALHEEKERLHITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPV
AGVVRLTNGKDGEEVENPIQCCLQENRALPADYALVLHGRDGRCFDIQQSVSPLKTIDGN
VMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALV
FLDLDRFKAVNDNAGHAAGDALLKDLSLLMRHHLRNSDCLARLGGDEFGLILFDCTREQA
QSLMQQLVNHISQHPFFWEGKIYHVGASAGVTRIDAYAGKSSELLAQADIACYTAKHRGR
GQVYLYEARQKMILERQHELLTRQEVTDIITDGQLLLHVRAVAPPKTPLAVSFYQLKLQV
RSQDGQSLASDDFISAARLYGLTQEIDRWIIGQILTQRAPDIARKGLSIALPLATDSLLD
ASFQKDLLAALDASSLQPGALLLAVDDAVVLEHADICRPFLQQLQQRGCKLIVNGFGHSL
SAFDELHGQKIDYIRVDERFITNVHCNQMDELMVSMLNGATHRVQAQTLAGPAHQQVTLH
TLQAIGIDLSDGDAIALEQSLTELLSGGYFGIR
>A0A2S4TCG2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ACNIH4|TrEMBL
MNNECMAMLAEQWKQICQNYSSDDLLHAFQFIQDHSLVLVEEFYKNMLLEKEASQYFTDE
LIQQRLRDTLHQWLSESFSVALNKRYAEAVQKQNIVGHVHARVGIPSWLIMRGVREIQRK
IFELLSLNPQPNMLTTCSYIIQIMGFATEIMCRSYEAKSVQNQEMKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSGTTGIRHQMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQIDTLNQAVLECTEKDQMLNLIQSIRDLNREIQHLVDQLFQVADYIESGNDSLTQLL
NRRYLNTIISREINFSRDNQTPLSLLAIDADFFKAINDKYGHAAGDLALKFIADALQKYI
QGSDYAFRVGGEEFLLLLVDTDQRRAMNIAENIRKFIEEGIITTAQGIQFKFSVSIGCVI
YDGHPDYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A1A6AW01|diguanylate cyclase|EC 2.7.7.65|Clostridium ragsdalei P11|TrEMBL
MTNMITLISTDILAIIALCFTINLAKRNVVINNKKNMIYISASVTTIILLILEISTILMG
SSSNSNLVIPYRIANILGFSLSPVIPFILFLFFNNDNTKNILHNFFLTIPLYFNTFICIL
SYKTGFIFFVNAQNQYARGKLFLLPTIISMFYYVLVLIIVIKNSIEYEIEDKKIIISIFF
IPVLGIILQLLFKNIILIWSCTSISLLLYYIFLLELQFRYDVQTKIKNRASFEKEMGQYV
NGDNNATIVMFDLNNLKVTNDKHGHKAGDEMIFHAAKVIEESFMGIGTPYRIGGDEFCVI
CKEASKELVDSTLSSLDDLLVKINQKRQIKIVLAYGHAFYSKDASESIYSTFYRADKAMY
TNKAKLKGFYGRRNTD
>A0A836NBI3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2-460-02_S1_C1|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNTIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A1T4ZM11|diguanylate cyclase|EC 2.7.7.65|Planktothrix sp. PCC 11201|TrEMBL
MRPLINWSCRLLGLPSLNELEANLLSETTKIEQMKQQQNALYRVISKIRASLDIDYIFRT
TTKETCKLLGAERVAVYRFYEDWGGEFVSDFEFAEPGWIDHESLGKNTVWIDTYLQKNQG
GRYKENQTLVVSDVLKAELSQCHLDVLQQFGIQAYATVPIFTKQKLWGVLAAYQHSNPRE
WQDSEVEFLAQVATQLGFAVQQAELLAQSERKAKDLQETSEQQQILLTVIAAIRESLDLD
ILFKTTAREVLRALNADRVGIFRFDPETNYCSGQFVSESVLPIYDSALITPINDRCFGEK
YALDYQQGRMQVLNNIYEYGLKDCHLKILEKFQIQAQIVSPLMKGKILWGLLCIHQCDRP
RQWTKTELQFVKQLAAQFSIALSHSDLLVQTRSQAEQLNLTLKELKTANLKLEKLARRDG
LTGIANRRYFNAFFNKTWETAKDNHQYLSLILFDVDYFKLYNDFYGHPAGDQCLISITRS
VQKILRSTDLLARYGGEEFAVILPNTNPDQAYRVADKIQAVVRNLTISHTNIPTGKSIVT
VSLGVSSQIPRSDLLPQDLINEADQALYSAKKQGRDQWVSWAQPLSVIGYQ
>A0A7H4P5Q1|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MSDFILARVTQTLANEHSLEALVRQLLEMLELVTRMESTYLTRIDFDAQRQLIMYAHNSS
EMQIPEGFSVPWNDSLCKRALDERCLFSNDVAERWRSCIAAQDLGIATFFSIPVRLTDGS
LFGTLCATSRVRQPYNLEGEQVMNLFANLIAHYVEKETLVQQLRSANVALEMHSYTDELT
GLPNRRSLFKYLAAQFPRAREQRRSMLLIFIDLDDFKAINDRFGHPCGDNFLIQVGERLA
AHVRSGDIVGRLGGDEFLIVGPGPELADQQEYIAALRQALTGIYFLGEHRINYPGASFGV
IEADPQQIDVEQALRAATTRCIWISSLVVREDFFILTNLR
>A0A8F9XC62|diguanylate cyclase|EC 2.7.7.65|Pseudochrobactrum sp. Wa41.01b-1|TrEMBL
MSKVRRHLDTRAQNTLSVFGKITFVAVMIWLLFLAGTGWWVSQAIIKAELNDVAVSVDYE
STTTAHVMDRVFTEMSSIANMVAGNADVIRLAVRYRTDPPGFANLTRQQRAVEFTHDPLV
RKVGEVMNRLAADLRYARIYMNNMSDDTVTASNWAESDSIVGMIYSGRPYLIEALQTGKG
SSFGIARLNKTPSYFVTSRIDDAGDEPQGSVTVKFDAPDVATYLTGRHTALIVNRQGRII
TSSVPAFMLRNVARLLPEGTVLPPDGEEELGEVLTVRAISNPTYENLWFIDGKQYLVKRR
PLSGTHYQLFTLASLERVEPMRRQHFWITALIGLLGIVFIVLAALAIRHSSLRRQDELYA
ANYDVLTDLPNRRAILVELDRLFTLAKRTGQWVLVVFIDMDGFKTINDTYGHEVGDKFLI
EAGRRLSEGLRADDMLGRFGGDEFIVIGQIAPPSTDGLEGSVDAIRNRLAPLLIGTYHFE
SCNFEYSGASLGVACVDPSVSSLKSALREADRLMYDNKKLRKNGSEYIVS
>A0A3S4RKP5|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aurum|TrEMBL
MSAPYVSSMPPDPVEATPDPHYARGMVRLLHAVQELSLARSLPEIQTIVRTAARELTGCD
GATFVLRDNGKCFYADEDAIAPLWKGSRFPMEICISGWAMLNREAAIIPDIYLDDRVPHE
AYRPTFVRSLVMVPIRTLDPVGAIGNYWGHEHEPTPREVALLQALADSTSIAMENVQIYG
ELEQRVHDRTAALEQANEEIRRLSLTDDLTGLNNRRGFHVLANAALLAARTHGHDCALAF
LDVDGLKRVNDEEGHDAGDVLIADVADVLRTSMSMSDIVARLGGDEFAVLVTEYGGGAAA
LKARLVDACRRFNETSGRPYLLATSIGVVEVPRTDISTLDELLTRADELMYEDKKRKSAD
AAVTADIAG
>A0A0M7EHY6|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRLVSPNDALIAPQAREAGRGRAGAADPRDEELARLREVVAQYEALFENAPVLINAFDQH
GKCLLWNEACVRRFGWTRDEINGHAEPLALFYPDPEIRARVVASVVREPNRSFREWQPLA
RDGERLSVMWSNVRLPDGSVVNIGMDMTENRRNEAALARLAKVDGLTGCWTRAEILQRMK
GLLETAKRGARHTALMLDLDHFKQVNDRYGHLGGDAALRHFCDQLRTCLREGDSVGRLGG
EEFVVLLADADKDVALAVCDRLRACLRQHPAQVEGHALVLSASGGITRFLETDASMSDVL
RRADLALYQAKRAGRDCAVVLPG
>A0A8F7U3S1|diguanylate cyclase|EC 2.7.7.65|Vibrio neptunius|TrEMBL
MVKLKHFSLKQLTILVSISVVLLFLVFYFTFKALWSHELAVEASKKRQEFEIERVQTVLK
MEELELRASLEDYAAWTTLTRYVQQPSDAFITDSIGPHAFESKLIDGMIIFDHQLDVKWS
ALYRDGQVHSTQFIELNDPAVVNKLLVQSINASSAKVSSHIKYAVHQNEPYMVASARICL
SDGKSCDFGYIVFIRKIRNDFIAEIEAATGVDINIHPISEHDSLHGVLPDYVSIIYRTDF
LNGNNIAIEIIHNEKLPTFLTFSEASVLACFSLVMFILNLSVVSKLIKPLEQAQKALRQF
QKSGDKLPNEASFISKEMKSFARDITNLITELDEKRAILKKQSIVDPLTGIANRRHLYET
ARYFIEELSYSQIGIILVDIDHFKQYNDNYGHVAGDRALRLVAQALRDVESPYEHLVCRY
GGEEFCVLLASDIELELDGYLSQLVSAIRHLSLEHAYSPTKPYITISAGATSKKTNTYDH
LTSLFQYADQALYQVKQNGRNGYQIISAN
>A0A8F7MT24|diguanylate cyclase|EC 2.7.7.65|Pseudomonas amygdali|TrEMBL
MSSYHRKGLAFAKRIYAPRSLGVSVGFITVAVSLYYVNAAHWLWTLALLNALIWPHVAYQ
IAKKSREPYQAEWRNLLFDSLMGGFWIGAMGFSAVPSVTVIAMMAMHNMAAAGPRLMLQG
LCAQALGVLISLAVLNPVVNLHGNIAQIYACLPVLVIYPIFIGWMSHQVTLKLWEHRNIL
RKISRTDSLTGLLNHGAWKDLLDLEYAKSQNQHQQCVIALIDIDHFKVINDTYGHLMGDT
VLQNISEALMENLRDSDLIGRCGGDEFCVILPDTRLFQAREILERTRLAIDEMTYSLQRD
LKVSLSIGIAAYSPELPDASSWLHEADKALYLAKSTGRNCVASAQDMPSELQPLSADA
>A0A8E6TW61|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Tennessee|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2T0BBD8|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MNLGNNLIINIYSIAILTVICIHCLKQEEKSSLKYKLYMKMLQVTIVMLVLDIFSRFDGN
PSTIYLFINHFGNFMTFMINLILPTLWLLYVHDQVFQEEEKTKRLYRPLFAINFINAVIV
VVMQFYQKFYYIDSDNIYHRAQLFLISVLIVVIFMLVAFFLIVVNRKKIEKKHYFSLMFF
SVPPFISIMLQIAFYGTSLIYNSVVLSFLIIFLNIQNHNIYTDHLTGINNRKKLELYLKE
KIRTTTVNKTFSAIMIDLNDFKYINDTFGHNIGDDALEVSAKLFKSCLKSTDFIARFGGD
EFCIVLDMSDRSGLEKIVCRINRTIKEYNELGGKSYKIAVSMGFAVYDYHSFMTVKEFQK
KIDILMYENKKVTV
>A0A8H9AGV7|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKEAQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGYWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A398U9P8|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MIQTTRISMGLFFKYFLSLTKIDLGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNENTNVKLIPQMNSLMVVVALFFLNAVIFLFMLMKYFTNKQILP
TLILSLAFLSGLIYLVETIVIIHKPINGSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTVFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHHI
>Q6R284|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLLLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMTVMDTLNAKEGRGTLYFAGQG
>A0A8H9ACE1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVSVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A2T0BHY9|diguanylate cyclase|EC 2.7.7.65|Clostridium vincentii|TrEMBL
MDNILSSKEDLISKTKELISKNEGPFSVVVADIDNFKNLNNLYSNSIGDEVINKLISILT
NNLSSTDVISRTGDEFNILLVKKGAERSFMELEEIRRYLSDNTFSLSDNQADNICFTLSF
GVASYPRDAKNVVELFRVADSALFRAKELGKNRVCLSEAESMVLKSNYFTKTQLDRLSRL
SKANDRTEAFLLREALDDLFKKYSR
>A0A398QAP1|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MRQDAEVIMKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGIQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQLRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIETSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVSKNRDYLLSTAHNAMDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIERWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTDFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A333U238|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SVWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKILPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAICTYLSMTGVISYAPLF
NFTAMRHAQTNPFWLGSMLFFIIPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIARCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHRLPQIKSI
>A0A2N9M7Q9|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MGNLSNPPLDPPRLPGIGRIIVVGIGSLVMVALAIAVSLFELHHDREVQHQYENTMALAR
LAFDAESLASRMHALQELGVQAGAGATAAALRKAVLSLDIDRAEWEQRVKDAMGRDVPAE
AKSQLAQLQSTIHAMRAALGLPAGGEAAAPEAAGAPGAGASAESDRAYLAAVEAAQAALL
ASMHASAERGVIAGYTVSEIAATAVVLASLLALVLGAVVAALVNRAQHENRATIGVMGEL
LRTDPLTGISNRRSLDENLPVEMARAKRTAAPLTVAMLDLDFFKRYNSRRGHAGGDSLLR
IAAQAWRKQLRPTDTLVRYGGEEFTLVLPSCHAEQACQLIDRLRPVVPDNQTFSAGVATW
DFQESGESLLRRADQALLQAKKLGRNRTIVSGREEQISLPLSSG
>A0A518FT82|diguanylate cyclase|EC 2.7.7.65|Gimesia panareensis|TrEMBL
MRVSVTFRIVAGLVLLTLSTLLIACSLKLAPNLNRVQMEDRARYCEALAVSSSLFLTQGN
TEALKGYLDAVVKHNPDISAAVLRQQDGSIFLQTGKTDDLTGTSAENRFNKVRIELREEN
HPWGQLEIYFPVENLGLLSLWQMPMARYITFVVACCFLGFYLFLRKTLQSLNPSKVIPGR
VQEALDTLAGGLLILDTREQIVLANKTIARALRSNPDQLQGQVVSQLPWIQQAEGETNDE
LPWTRVLREGTTHKGVTLSLESNAAVADCFVVSCAPVLDDLGRMRGVLVSFEDVTELEKK
KSELREMLQALHESREEIQKKNEELQHLATRDPLTSCLNRRSFYEQMETLWEQAQKQGTP
LGCILLDIDHFKSINDNYGHSTGDLVLKGIGGALMDLVEEPGVLCRYGGEEFCILLPDHD
IDQTDQVAERYRLAVESLEFDDLKVTSSFGATAISLGAENPQDLLDEADKCLYAAKRGGR
NQVARWDRVPRDMDFSEPIAREPTPAQQEPAQESTEVSTEVAISLGSNMECLAQMIDAHD
FTGLSCIAEQVRLTAGRHGISAIAEVAGQLQQAAEKADVIEAIYLTNRLMELCQSYQSLH
LQHTVD
>A0A3D1C5K7|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEVGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A486D078|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLEQYQQLQRTDKSIELRLARLKDNGASREELALLHDGLQIAAELQD
EQQAALAHVAHGDAPAAIAVLYGNAYETELERMQTQIDRFRQMLENRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAHAGQSLCVPLIAQGEAIGLLTFHNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGTAFRYGGEEFLVLLPGLDEAEAHQCASEIYTQVHAMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A377U0G3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MATLELGYLLNLTQHDRDFAERMQYISRSGFFTSTLPLRDELQVITHYSQALSAPWFTRQ
TQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIKAFLVSAM
QGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPREQELLSRAFVHDNQGGLRLLTRYISWA
KLRNFDGVLLRIHTLREGVRGNFGTITIALTLMWILFTLMLLLSWLVIRRMVRNMSVLQT
SLEWQAWHDALTRLLNRGALFEQAMAVASDCQRSGRPLAVIQLDLDHFKHINDRYGHQAG
DRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQEAAAVAERLRQRIQGREVFLH
NNVTLRVSASLGVSASEERGEYQFEALQSVADGRLYLAKQNGRNQVCFRSAA
>A0A377TVW3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MASISLVGEDLLHIKSCAGLDVDTVPRDISFCAHTILQTDPLIINDMQQDERFHDNPLVI
EAPFIRFYAGYPVQLPDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAAT
SDELTGLFNRRGFLTLAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAI
ADLMKAAFRESDILARQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAF
SWGCVEYDPASHPSLNALVATADRLMYQAKQKQGRERR
>A0A2X3EXV3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MSSLSIRSFTLFREEQPVRDALVLFTLTLLLHFLGAMLRLVQELSFFWPLNAVMAGIFAR
YVWLNRSYFYAVCFAAMLVYDGLTSRWGMGFASLLINFSNIVFIVTLAQLVLWDKRRADS
MPGPINALNLFCFCLLSALLCAAVGALGSVDVERATFVPQLADWFSEQFSTAVLILPFIL
TLTLPSALSGFRFRQLLPVLALVLSIALGVAVGGAGSITFPLPALIWCAVRYPLPLTCLL
TFLTGIGEILLVANSLIHFSPDARMQPWQLFSTRLGIAAMLISPVIVASSVEAINTLVKQ
LALRADFDFQTRVYSRSGLSEALKRQTLPADKLLTVMVLDIDGFKRVNDALGHEGGDCVL
TQFAQQVRQLVGEQGMVARIGGEEFAVAAVVDSAQQGYLLAEKIRHGVESQPFGLGQNPI
HLTISLGLETREVGHARITELFNQLLLAADDEMVKAKQSGRNQICMPTLTESAP
>A0A2X3H310|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALAVHTHTPLSCLMIDIDHFKTINDRYGHEAGIW
>A0A486RVG7|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHVGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLTGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A486UX37|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLVIVAVAVGCALVSPPVGTRHEILTNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVYGLSDPELHAL
AQSILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
SAGAAG
>A0A378BPZ6|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGGRIYHSVRQYQPPRCRGGNGDAQPQRGAFQPAGGQSLAAGVLLGLRRI
>A0A3S4GLQ2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MALHNRKLSFTTPIVVGFAGILLSFMLIAIFVTLAQQKDFLEDYHDINRNFTHNLAINYT
ETLLRENDFILGRAAAFFARNDELNRAVNVEPEKGLTTLMQLQNMMPSVSSISLADTEGH
YLRAPEVLENEDSRAFDPRTRPWFIKQAEASTFSHYTSPYMDYFTHHPTITIFKPIITPE
GKLKGSLAFHLDLTSMGFALRQMVAPVQGEFFVVQRDGKVVLHSDPGALFKPFVRDELMD
KMTSGEGQLYDPGSDTWYYYYSFTNPDWFVIFRVDNATLVNLTRHETNLVIGGFTLAAII
IILFGLYLRHASRSVLMNIINAIKTGDVKRAPRLEAMLSKAIETNKQRELSYVRQATIDA
LTGCKNRRAFDSDIAALMNDHQPFALALVDIDNFKSINDTWGHLNGDIVLRNVAREGLQV
LQPLEISLYRYGGEEFAVVFPAEHIDNARTLLETWRINVERRTWREDGLTVTFSAGLGEW
NMEPLDKLVVSVDEALYKAKQQG
>A0A5E4TNL6|diguanylate cyclase|EC 2.7.7.65|Pandoraea terrigena|TrEMBL
MPISAVFISIAILSCVMSVAVLGSLFGTGVPGVRLWCVASALLAVVAALLLTGTSDVAVA
VSSSMLVIASLIGLHGFRQFLNTRSSYAWEYVALGAILVMLIYWTFLSPRVDARSTMISG
CIAYVRFSIGAAVLKYRPRARPKYAYYFVAIAAMLGAFVHAIRSVAYGVGLAHEATFLQP
TPLNVVFLGMATLTLPCLSVGMVLLAHDRLADRMERLATFDDLTGLLARRAFIARAEALV
RECVDRKSTFSIAILDIDNFKSINDRYGHAAGDLALAHVASLIAQAVRATDIVGRIGGEE
FALLLPAETKENAGRLINRLRDIVATSGSCVPGRDVVSTLSAGVDAFRDGDTLASVMARA
DAALYAAKAKGRNCVVVAPAIEPLPLEPLAQANGVRFGGKTANG
>A0A2X1QXE9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MLLKELAVFEVLSTPIWVVHPFNERVVYANQASRTLSGEMSLNEMRNGIYSTCPETQLQH
YLRYLDTMSEIFEVWTLPTANGLQSVYCKTTLIDTEDCGCLLLFEAVKLLAQNQSIHTGS
RRYQRRNNGFFARFFMTNTAPMLLIDPHKDGRIVDANIAALRFYHYSDEEMRTKHTWQIN
TLGRDVIPIMNNIANLPGGHKPLNFTHILADGSLRHVQTYAGPVVLYNIRLMLCIIHDIT
EEVHLKKELEFSAAHDPLTGLLNRREFHRLVEAPTFIPRGYCLLLIDIDHFKSINDIHGH
QKGDEVLLVLSRILETSVDREDKIYRWGGEEFLLFLPHSPIGRALILAEGIRQAVSEYQT
LSVTVSIGVAEHHDGETVDQLFSRVDKALYAAKNDGRNRVTRMPFDSPERRRSRDGAA
>V0BA51|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 909957|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGHNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A2X3GSW5|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVMPNTTLQ
EAAAVAERLRQRIQDGKSFCITT
>A0A4Y7S7E2|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. FP|TrEMBL
MMTSSNRAFLLLVKKDVIVMLHGYLAYIVALLIASVISLLMALFLFIRRTKTGAVVLAYL
MLSTSVYSLGYAFELACSTLSGMLFWSKFQYLGISIIPALWIIMVIQMTGRDRWLTRPVL
IAIFIIPFTTFILHLTDSYHHLYYSSVSINTNSPFPLLAFTKGPWYWVHVAFTNLSILCG
NIMLLDMWRRSAPSYSRQAAIILTASLAPWAGLIIYQTGRSPWDLDLTPFTFTCTGLITA
WGLFQYRLFDLIPVARDKVFDSMRDGVLVLDTSDRIVDFNPTAQLIVKKLSKKDIGRPAK
EVLADYPELLKQLSVNNNEQNNLQTSQGGVSYYYNSRVTPVMNDKNKLIGKTIVLNDITQ
QVLLHEKLSKLATLDALTNIFNRRHFLDLSNDELCHAKQSGTSISLILMDLDHFKQINDT
YGHKAGDIVITTVTAVCSNNLRVTDLFGRYGGEEFVAFLPETSSEEAFQIAERLRQNIAV
TRIELDDGSITVTASFGVASADKAGDIELDELLKNADEALYEAKEAGRNCVRRRFLN
>A0A5B9P7Z2|diguanylate cyclase|EC 2.7.7.65|Mariniblastus fucicola|TrEMBL
MTKIRSATRMALSIGIGCASLIWIAAAIGLVPDPALEQGRSRIGTARTLAVNVATYAENR
RQVNLKKLLERTVESDDNIVSIGVRRTNSEQHLMTFGPHVEYWNLDHRNDAAKQISVEIL
ASEQPWGELEIVFAPYQFSGNILWLSFPFGLVAFVFTASSLFAWVILSKSLKYLNPSNVV
PSRVRSALDTLAEGLVLLDGNGEIAHANESFKKITSSIGEDILGRKIGDFGWQKEATELD
EGMPWELCLEDQQRVARHVLSLTLPDSTLKKFAVNATPIYNGEEKVRGVLVSFDDVTALE
NKNSELAKIIGSLRSSRDEVARQNERLNFLASYDPLTKCMNRRSFFDQFEKYWNDEDCKL
LNLLMLDIDFFKNINDTHGHSIGDEVLVLMGHLLRESVGDRGIVCRYGGEEFVVLIPSIT
VDQCESFANDLRQLIEQSETSGVKFTASLGLSCRQFIPMDAQHLLDQADESLYLAKGSGR
NKVVRFDKRLEYKELIDKAAVAEAEQGKEIPYTAVTGLLSALSFRCPRTAEHSIRVADMS
VIVGEQLMNRRELYQLEVAALLHDVGKIGVPDSILHKPGPLTKEEWVVMRKHDDIGAEIV
RSALSSEKIAHYIESHHQEFSADDVGTDTVMLMPLASRIMTVCDAFDAMTNDRVYRPAMS
EDEALQELERNSPGQFDPQVVSILCEHVRSGVHKPKSEVGRPVFSTQQANAIGEHIEELY
VAVSDEDVEKIKNVVQQLRADASGDSQVDEVANRLDDAIGVTPQADLEEVLNLANEVMQI
CRESRNTFVQTAESIVAD
>A1KC37|diguanylate cyclase|EC 2.7.7.65|Azoarcus sp. (strain BH72)|TrEMBL
MRLFPARFSAMSSAGHFSHETIESDWLKLFDAVSPSLREAVRDVVLEHRAAMADAFYARM
MADGDARPFLSHEAVHQRLRFSMQRWMETLFSCADHAAFAAAMALQRHVGEVHSRVDLPV
NLVARGARVLKGEIAARLPASGLDRAALVQAVLYVDNLIDLAFEVMSSAYVASHERATRI
DEAYRVFSYGQNMSLERERQRASLLDWENRFLQAMMAGQSGDELPLISDSAFGLWLQHKA
VAVFEGSAELPSIREGMRRLDRDLIPLCRQQMESLDERGESRRLIKAVQSELGQLKFLIG
AMFERFVDLESGKDALTQLLNRRFLPAILTRETEIARNQHKSFALLLVDVDHFKQINDVH
GHDAGDRVLQQIASLLLNTVRSGDFVFRYGGEEFLVLLVEVDRQHAARVAEKIRQRVQQE
TFLLPDSRQLQVTASVGVALHDGHPDYQRLINQADDALYRAKTGGRNRCEFATDA
>A0A2N9M5E4|diguanylate cyclase|EC 2.7.7.65|Candidatus Sulfotelmatomonas gaucii|TrEMBL
MKRAVALFAMLAGCMPGVCAASPAPLTTLRAIAALTNAQASRHVPVSFEATVTYFRGYDA
DLFVQEADTAIYVHTATGLKLVPGDQVLVRGTTHESFRPFVDGKEVFRLGHGPLPRPERA
SIAQMVRAETDCRLVTVRAFIRSADIVPDSRSFVPAIYLRMIVDGQQVDANVDSSDENTL
KDLLDAEVQITGVVSGHFDNKMQQTGILFHVQSLADVKILERPGFDPWSLPVTPMDRMFT
GYRVRDLTQRMRLEGTITYYQPGAALVLQEGSKSLWIQTDDYRPLRIGDRATAIGFPDIE
NGFLTLTRSEVRDSSLPAPIAPSLFAWRDLASGGNLSASHIFDLVSIEGQVVTEVRQATQ
DEYVLEAGGHLFSAILRHPGSLSRIPLLPMKQVPLGSRIRVTGICMLADANPFNGDVPFN
ILIRNFDDIAVVARPPWLNVRHLMLLVGLLLSVVIAIGIRSWFLERRVRHRTAALAYLER
RRSRILEAINGSRPLSEIIEQITEVVSFRLHGAACWCEIADGARLGKPPLRITSQRIIQH
EIPGRSGASLGTIYAAIHRLNRPRPEESEALSLGTNLASLAIETSRLYSDLVHRSEFDLL
TDVPNRFSLERNLEALIHDCGQFAGIFGLIFIDLDRFKQVNDQFGHQVGDLYLQQAALHM
KRQLRPADTLARLGGDEFAVVVPAVRNRDDVEEIALRLERSFDEPFSIEGRELHGSASVG
IALYPDDAGTADELLSRADAAMYAVKQSRHRGGQMPAEDSAQDLAHCA
>A0A8G1GQ21|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MNESSELSTRPKVLIVDDSRIVRATVKKHLSEHFDILEEADGEAGWKRLLADTSINLMVS
DLTMPELDGLGLLARIRSSGDDRLHHLPVIIISGEEDEATKLRCVECGANDFITKSTDRT
EMLARVKANLELAATRRELAESRAVQVQTTTDELTGVGSSHLLDLQLNQALAFALRHNSE
VTLLLLEVNHHQALNDKLGEKLYGQMLGLLAKLLEGKLRKEDTLAHLTGPMFAIVSPATP
LTEARIVAERLRNSIANARINFRGQQLRVTASISVANSWHDDAQSSERMMMIAQDRLYAT
PIENQVFMPEVNTSIAPTPLIAEALVMLHKGMGTELQPHLLALMRNLQPLLAMANQELNL
DWDLSRLDE
>A0A8G1GPH9|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MNWPSFSLLLCTVLTLALAVLAAKRKVFPAQYYFVATLLGSAWWSTAAAIELLLTSPSSK
VLFAQLAWIGIMAVPTFWAMFVWSYVKGYYQKPSWRWQLGLWLMPLVTVAIALSNEMHHW
MYVSTLPISAEVGAAIVYQHGPWFYIAALFMYGYMTLSMLVLLNALARASRLHRRHYIGL
AIAMAVPWLANAAHLTGLVTLFDFDPTPFSFLLMGCIFYWLVSHRQLFDLLPIAHDVLLD
AMPDAVLVINEAKQIAQLNQAAQSLPNMPPNATGLPLARLEYLNSVLPLLWGKELPVEFE
IELGDTYYDLRSVTVYYQQQAIGLLLVLRDITHQKLIQHELKQTLNILEDQIEANALLQQ
QLREEAIHDPLTGLHNRRFLDEIAPNLIANASRKEQPLSVVMLDLDHFKTINDQQGHAVG
DIVLRHVAQLLQTNLRQSDYIFRIGGEEFLILMTDTLSEQAIQQTEVWRAALRQQLPQIA
GRDLPVTFSAGIAQQSDEQLNLANALIQADQALYQAKAKGRNRSEQAPHQAPYINQACTS
PTLAQPQQA
>D8G6R0|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MRPKSKADSTASFDDQSSSLTQPVLLNRIANRIRQSLELGEILSATVAEVRSFLGTDRIK
IYQFQPEGHGLVIAESIYEDRLPSLYGLNFPADDIPTYARELFLRARQRTIIDLSTHQIG
ISALDSVETGEPLETQDIRYRPIDPCHLEYLIAMGVKSSVVVPIVIETASRSESELPSLQ
SNQHLWGLLVSHHSEPRTVTEEELRFIQSVVDQVSVAIAQSILLEQVREQAKQEANINRV
TAVLYTLPPVKLQAALEETVALFRGSGGRLYLPTNETQQSIELYVCGTQPEQIDRIHNRY
IEENLLWQKFLTAKVHAGDSKSSSGIKPWSVEWMRAMYALSAVPWESNTNSNIWPIADIY
REPLFRTLVPAFQNTQIRGVLIVPLYFGQEVVGCLTIFREDSDREIVWAGEHDPDTRQLS
PRQSFAAWRQIKKEQAQSWTEADIRLAQALSELFSSAVKHYRLYGQLQTLNANLELQVQV
RTAELQHSNAIANQQRAGAGILSKLQKALDVETICRTATQEVRQLLNIDRVAIYCFDADW
GGGFIRNLESVSPAWTQIVLATRTVWNDSYLQETQGGRYKNHEISNVSDIYNAGLSPCHI
EVLEHYCIRAFLVIPIFIGDKLWGLLGAYNHSTPRLWKDSELVFTNQFAAHLGAVLDRKQ
AEIDLLEAKEQFELALRASHDGFWDWDLVTGEMYYSPRWKEMLGYDDSELPNSPETWKAL
IFDEDYPLTLQLIEDYNTGKVDQFLMTQRFYHKDGSTVYILSQAIHVKDENERVVRMIGA
HSDVTKMVKIQEAMETSKMQLASVLNSSLDGIMAFRSVRNKAGEIQDFEWLLANPAACEM
INRKPEDLIGKYLLEEMPGNLEEGLFERYIQVVETGTMMDREFCYDRDGLNSWFQNIAVK
LGDGFVVTFRNVTNIKRSEQALQEANRQLEERVGELNQRNSEMVLLSEISDFLQACLTIK
EASATIATLVQSLFPECSGGIFITANSRNRLEIVTSWGNPLYSETIFHPKDCWALRRGRV
HWMGSDRHELICNHINHKDPPAESLCIPMIAQGETLGLLYLCTTAPHTISESKQRLARTV
AEQVGMAIANLTLRETLQNQSIRDPLTGLFNRRYLEEFLTKEIDRAQRNHYSIGIIMLDI
DNFKQFNDTLGHEAGDFVLQEIGYLLKKMIRVSDVACRYGGEEMTVILPESSLEDTYIKA
EELREAIAQLKLNYNGKRLEGLTASCGVACFPDRGTTGNAVIIAADAALYQAKGSGRNKV
IVAKK
>A0A8G1GQK1|diguanylate cyclase|EC 2.7.7.65|Deefgea sp. D25|TrEMBL
MILSVLSKSADAPTPSFDQIPCAILVTDSAGVVQSLNQNLLLLIGGDKDSWLTKSMELMF
PMASRIFLHTHIWPMILRDGHVREIRLQLLDSGGNSLPVFVNCQKTNQEGIDQFTWVLFV
TIERSRFEQELLESRQRTENVSAALAKSESFIRGVFEATSEGIIVTDSDAIIISVNPAFS
KLTGYSQEEIIGQNARILKSDRHDADFFLAAFQILQENKIWDGEVWIQRKDGSIFLGQLS
ISAICDQNDVVLQYVGLCSDITERWDREQLIHQMALHDGLTGLPNRTLLMERLSQMIAKS
HRDSRQIALMFLDLDGFKKVNDTLGHAIGDEVLKTVATRLSGLLRSTDTVARLGGDEFVI
LLDNPENGEAIAQIGARVISVVNEPMHFDNAEAHIGTSIGIAVFKDSACTPEALLKKADE
AMYSAKAAGKNVYRFAE
>A0A3M2RF97|diguanylate cyclase|EC 2.7.7.65|Marinobacter litoralis|TrEMBL
MTANDNAPLTTTSDHLLPFIESLPDAVVIVDQNHKIMLANALAGRMFGFAVDDLKGSDLS
TIIPMPLRNAHRKHVNGYFEKPVLRPMGEEKRFSGVRSNGQEVPVDIMINIIVLDGAKVA
MALVRDVTYQRELEARLTLESLTDEMTGFYNRKHFKTQLNAQLSGYVRWGLPTSVIMFDF
DHFKKINDQYGHAAGDLVLTTIAKMVRQELRPLDVGCRIGGEEFAIILPNANLEDAETLA
ERIRKLIEQKEFKLDEVSFRATATMGVATFLPTDTSYDSLMRRADNVLYVGKAAGRNRTV
TQNALQSTDFTG
>A0A517VH36|diguanylate cyclase|EC 2.7.7.65|Gimesia algae|TrEMBL
MSYLIASIIEVFTQNVSQGVTNASVAAIAGVCLLQYIVYTFKMSAVREENEQFQRNLSEF
EEELHDIQSDRAMTLIENHILREFVSQSDFDQAIELLLKRYVPSLRDGFGLYLNHIDGEF
KLRESRGLSRNTKAIYDIDRSILKQLRNQNVLVLRGEKLRESNVYDCFHDQDKARIQKLC
LMAVYDKKDISGIFITTDLYPEGVEEIQQIKLAKRLLICVSRNIVKNQDFESHRFELRVT
REQLELRSLADQQFKTPVIMLEEFLDRLRQLTNSSRAGLFLSTPGDASGCKAIVECGITL
QSGVKARWREHEMNLVQLGLNSGENTSLSGDQLENHGIRSLVGAALISPLITNRKRIGVL
CLTSQDSQPFDERSLRLISWASQFLSNTLLKVLSHATIERQARQDGLTGLVNRRSFDELF
EDEFHRAQSTEIACSLILIDLDHFKLVNDNYGHQAGDEVLRRVAQILRERIQEIRSSDNV
IAARYGGEELAILLPEVGLSGTERIAEVIRHSIESSVIKFNELHIPVTASLGISTYSPHV
MDSVQAMLAAADSALYQAKAEGRNRVCSLSSAPV
>A0A8F6YBH0|diguanylate cyclase|EC 2.7.7.65|Gymnodinialimonas ceratoperidinii|TrEMBL
MAGRILVVDDVATNRIVMKVKLTAACYTVEQAENGTDALRLARETKPDLILLDLMMPDMS
GLEVCRALKAEPETADIPIVLITALCDRAAKMEGLEAGADDFLCKPVEEVTLLARVRSLL
RASDSVRELRGRDEGVSAYGFAEAALGFEPKVQPGRVALVAPGPRGAVLWKAAIEERVGG
TVQIMPKELALASAAEAEAPDVFVISVDLGQRNEGLRLLSDLRSRPGTRHSASVMILPEG
DTERAAIALDLGASDVLHDPFDAQELAIRISAQLGRKRQSDRMRAGVRAGLEAAITDPLT
GLYNRRFALHRMEQMLAPPAADLSVMMIDLDFFKNINDTYGHHAGDAVLREVAFRLRGQL
KPSDLLARIGGEEFLVVLSGADREAASACAEQLRGCIGAASFDLGDGSFPIRVTASVGLT
LPGGLGDGVPVTAEALIRQADRALYGAKAHGRDQVSYTQGAAA
>A0A1Y5TM87|diguanylate cyclase|EC 2.7.7.65|Aquimixticola soesokkakensis|TrEMBL
MSEDVELVKRISRLGSVSYRPLLSFIRLRMFFSRMAVIISVCLLVATPLDLLAPMRSYFG
VATLSPLTLLAVLSQALGIVLAPRFGRKHDHSWLLGSSVAAAIALARLAEIYVVPVEFIS
APLNMLLHEEIRGVSAMGSNTAVSVLLIALSVLLRRRAPYLALWSVIIGISQPVIGLVGY
SYGFAPLFGQMSIPSIGLLLLNGLAALTLFPRTALLRSIFNSAAHGRFARNQLLLSFVVL
WILGFALRHAPVYISAQHAMAVMVSGMLLLLFFLISVSAQMTERAECTRRKLERELSQML
MRDPLTGAANRRAVDVFVQNALRRSRSGKRGLGNRPRGALGVMLIDLDHFKEVNDRFGHR
TGDDVLSGVASVLRARIKRSDLLARWGGEEFLVLMPDVTGVDEVRDLAQTLRESVAAHVR
ISRTGAGGVAQSIQVTASFGCAIVGREEQDHAAAVRRADEALYAAKFRGRNCVVVEESVD
APQLATVTVQVG
>Q32CY4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MANARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNR
NFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAQNAQLLRTALHDPLTGLANRAAF
RSGINTLMNNSDARKTSALLFIDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKA
YRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHAS
AEKLQELADHNMYQAKHQRAEKLVR
>A0A514V8P3|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNKEITSAPRPTFKRTLRRISIISVLITMTLIWLLLCIASVVTLKQYAQRNLELTSATMS
RSLEAALVFNDATAANEALASLGKQGQFSAAELLDRYDHRFASWSMGPNDKADPLSQLAS
QWLFPHPIRQRIWHNNLPIGELHLTARDSLIGHFLWTSLAVLTGCLLFASLVAITITRAL
HNGVVTALQNITDVVHDVRTNRNFSRRVSEERIDEFHRFGQDFNSLLDEMEEWQLKLQAK
NAQLMRTAMHDPLTGLANRAAFRTRIAALMSDSSARTNSALLFLDGDDFKRINDTWGHAA
GDCVLIEVARRMVEFGGEQHQSYRLGGDEFAIILYGVHSEHEVLRLCAALTQQFSPSYDL
HNGFSSRMSLSIGFALSWQHHSVEALLEQADRNMYLVKHQRSKNHTVERNTLC
>A0A1V5UPJ9|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin243|TrEMBL
MFKYASILNKPLFDDLCEPVIVFGPDRKLVFLNLAAKKMFGKKADKIAGVSCARLFGCAQ
AGSGESCPFESFSSPRVKKLNFKIPSGSSPFTEKELSGTAFPVYAGNKTTHGAAFVVKNF
RAKSEIDYFRKRADEDLKAGEERYRTVADFTYDWEYWTSPEGEMIYVSPSCERISGHSPE
EFIKDPGLFYNIMHADDRRKTIQYMEKVSKRSGISEIVFRIIRPDKQVRWVHHISQPVFG
SGGKSLGRRASNRDITERKMMEDAILESEERYRTVADFTYDWEYWISPEGGMRYVSPSCE
RISGYASEKFIGDPDLFEKIMHPGDRKRAVSLMREASETSAVCETDFRIIRSDGDIRWIH
HISQPVYSKNGNYLGRRASNRDITSRKKTDRELEESRKKLIEQNLELERKNIALKEVLGR
IELEKKEVQDNVMLNVENVLLPILNDLASASNGREKNNIELIKKNVGDLTSAFGSRISVK
SLKLTPKEIRICNMIKNGMNSKEISEMLKISLRTAETHRNNIRKKLGIARAGVNLVTYLQ
NYFSL
>Q32JD4|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae serotype 1 (strain Sd197)|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFTRRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDTVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A1C6H2J8|diguanylate cyclase|EC 2.7.7.65|uncultured Anaerotruncus sp|TrEMBL
MKKALCLLSALLLAVLAPLSVLASAENGDYIIDEERVIRVAYPIQRGLTDVDEDGNLCGY
TYEYLQEIAQYTGWSYEFVQTDGSTDSLMDLMEQVQSGEIDLMGAMSYTEAAAEMFNYSS
YSYATSETVLQTSYSKMQEVVFNSQLPQTFKIAVTGNENSRNVKELQDYCSLNQITPEFV
HCDNDAEMVKAVQEDRADMLLSTSFNYLEDMWTIAKFSPKPVYFVASKNAKADIMEDLNT
AIMHIEQSDANFATRLYNKYFLPQTKDLVFSEAERQYLQETGVLKVGVLSGQPPFQQVGV
DGEASGVAIDMLDYIKTHTGLEFELVYADSQNALYDLVKEKKVDLVAGMPYDYDLAQAKH
LSMTQPYVSSQYILVMNDKSSNDSLKDKRPALLANSPFRGDADTEAAIYETTRECVHAVA
SGEADYTYIDTYSAQYYMNQPEYRNLRLISQNYGTYTVCFGVVKPGRQELLSIFNRVIST
APEEDIQNIINKNTLQKTPFSLGDLIRQNPVGSIALVGGVLLVIILILLYFLRQRARMSK
QAALELKKHLQVYALVNEYFFEYDFATDTSMVSVPPKDTQGPSQLVCIDHKKPLEDEMLR
ISRERFLEAVRSVQNGIQEIELYWDGDMHWVRVALETVLDGDRPIYTLGKFNIIDDEKKE
KEELLEKSQLDSLTHILNAETCRSRIVEDLQLLQDGEHGAMILIDIDRFKEINDTYGHMK
GDEALQSMAVLLRSTFRADDVVGRPGGDEFIVYMKNVTDTEALRAKCRTLCDRVQQLTVA
GGGLTISAGGILARKGDSYNDLYVEADQALYRAKNAGRNRFQIAPRN
>A0A1V5UQY5|diguanylate cyclase|EC 2.7.7.65|bacterium ADurb.Bin243|TrEMBL
MSLLNKKTVNSIIFIIYAAVFALTFHYYNRGGFEGVEARIIDANFKRRGAVATDKKILIL
GFTDACMDSLGKWPWKREIHAEVIKKLCSAGVRAVAIDVLFQDKSAVPGDDDALIKVLSE
NKNIVLSAVISPKTVYQDGNIINTRHVIMPFSELAEQAGGIGFISVNYDALNPDGILRSV
SLSDIDENKKTVNSFSAEIARISGMSKVAAAAGTRYYVNYHGPAKTYEYLTFSKVFSGGL
PLSYFKDKIVLIGPLATALGDLHHTPFGTMPGTEVQANILNCITSGAFLKRASPPAVMFT
CALFLFACALSLTLRGLLVSSAVCLFSVIFLLVSNPLMFSGFNFIFDIVPALTSLLLSFF
ISALFYSYTKLMISNALLNKKVRELNALYSISKNISELINLDKILKDVLNEAITTLGAER
GSLMLIDEDEQKLEVKVVAGVEGPLEHKILIPIGQGIAGQVFSEGVPIVSNSTDSDQRFK
TFSEYGENEVKRAGVKNLLCVPLLISEKKTIGVINIVNKTDKSTFSPDDVKLMETISHHA
ATLIENSKLYKLATVDGMTGLYVHRYFQVRFKEEFSRAQRYNKNISALMTDIDHFKKFND
TYGHQCGDMVLSHVARIVRETIRNIDIAARYGGEEFAVALPETDAEGAYKLAERIRKNVE
ESFCVTPKGDLKVTLSIGVASFLNSKAPTQLALIACADSALYKAKESGRNRVMVFTGEAQ
PITHDDD
>A0A1G0DSE7|diguanylate cyclase|EC 2.7.7.65|Gallionellales bacterium RIFCSPLOWO2_02_60_31|TrEMBL
MIKLKQSKEFAADWRRLSEETPAPVQQLVGEIVRQQAAALTDLFYRDMLADQEARAFLDN
GLVNQRLSAAMQRWLCELFSDNQQEPEAIYQYQCHIGEVHARIQVPIALVMRGARILKHA
IHGHLVASSLERGELVKATNFVAETIELALDAMTDYFVIDMEKQTRTDEAYRMFALGQNM
LAERERQRAAILEWAQQILLKLLADGGEAELPGIKHSEFGMWLQHKAAIIFETAPELEQI
RQRIEEVEKSLFPKLLDSRRNPGDASMLMKQIEAGIAEIKFMLGGLFDRFIEVESGRDAL
TRLLNRRFLPAVLTREMAMARRSGVPFALLLLDLDRFKKINDTYGHAAGDLVLQQAADLV
TGSVRAGDFVFRYGGEEMLVVLVEVDRDQALHVAETIRQRFAAEPLRVGDGQTAGVTASI
GIATYNGHPDYETMLKDADGALYEAKEAGRNRCVVSGR
>A0A3P4B704|diguanylate cyclase|EC 2.7.7.65|Pigmentiphaga humi|TrEMBL
MPNSPSRNRWRVRGEITSRREVFQRTIVTTLLVIVAADLIDLCINLIYAPFQIVRSAIQT
TLIASVLGSSVIYIMAMGNYKLYQMKSHLANLNRLDPHTGLLNRRAFIELAETALASARP
HVLMLADVDAFKRINDIYGHPTGDHVIVTLARLMRSVFGPPCEVARMGGEEFSALLVPAT
LEEAVRLAEAFVRQVAVADFSMNGPPLHVSVSVGLIPIARGASFADIYARADQAMYRAKA
DGGNRVKVAS
>A0A378Y993|diguanylate cyclase|EC 2.7.7.65|Nocardia otitidiscaviarum|TrEMBL
MPTGSERDRCAIVRAWWNDPVDYRWLLRTLAARSADWPVRIVVGAGGAVMVVISVLTWIS
PAGPHGTAGHIVFAFVTGGATLWALRWWLGPWPGENESLLLIGAADLLVVSACLMDQDRV
YGSIGALLLVVTGGYVSVFHSPRALTAHAVFSLVSVIVLAARLAGETGDVALAVAIVLIM
AVAIVVVLPTVHFCYWVLRTDALTDALTALLNRRGLDYYLSGRFGVDDGRAVCAMVIDLD
DFKAVNDTYGHSAGDDILVRTAARLRACADGDTLVARSGGEEFAVLAHLDPAAAQAAAER
VCRAIATMTGPHTPITASVGVAAFEHGATADDLLRCADAAMYRAKQLGGNTVVLAGRAAT
NPVSAAPRRGVPRA
>A0A1C3JR01|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MQKFDFQEFVTALDAGQQAHLEWSRRILRCTVLRSFPDDDVMHNDAHHLCQFGQFLAQHL
ITFTSINAEQTQRLVTVHQQMHDTIRNLARPISQGLAGNIEDLEHFERCQAELIDHLAYF
KTQAIYHYTQIDNLTGLPLRQRLIQEFRGQQQQCSGALALMFIDVDHFKSINDLYGHNMG
DTVLQQLVLRIHDVLNIDQSMYRYGGEEFIIMLCAAQVKQAEALAELIRHTVYHTPIVHQ
DDATIQISVTIGVALARHQEPLVSVIERADKAMYYGKQHGRNRVINADHITLENKS
>A0A1C3JQG7|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MSSSTIYHSGCLTPYKIALATLLDQSVFEFNWQAIECLQEVPVSGMVLLHESDVQDSDTP
LIGARKVLMVLAKWNFNGALKWVEQGANDSAGLEDLERIATWVVAEQSRSIWHNPQPSDQ
QNTLQTVIDAIPVPIFYKDAWHIYRGCNLAFSEFIGLSKEKIIDHSVYDVAPKELADIYY
QADQALLAKGGKQEYETDVKNAQGERFEIEFHKAVFYKSNGNKGGQVGVMLDVTEKNRLM
RELDKVSRTDPLTGVGNRREFDDAVSSALGEAQASYSSISLLTIDVDHFKSINDQFGHSC
GDEALKFLVRCIYLASPSNASIYRIGGEEFYVLLPRTNLAEARSAAEKVCQHIPSQPLIL
KGEQVNMTVSIGAIQLASEQQLEDSFKRVDQALYEAKMTGRNRVCLAYYD
>A0A1C3JUV8|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MRAGLTILVMKGASVVESLLVKYLGVTKSNEQYRHLSLVLISILTCTGIAAFFAFYNLAI
DYYPPLFYVDAAGMVMGLLSLSTLLLFRRVLLASFILLVMVSGVCLMVIMDRNNLDYSLA
WALVTPVVSVFLLGFLYGALYSGLYLAFVAWFAGRNLGVWQPAPWDIDSFSNLWVIYVLL
FILSCYYEFSRRSAHKLLQESNEKLRIQAVTDALTGLYNRRYMEDLLLNSDQDLFIAMAD
VDDFKKVNDELGHVVGDDVLVGISNVMRSTLGSNGAIGRWGGEEFIIVSYGESEENFTDQ
LSRMLDNISSHSFGVNRPITISLGAVRHSAKEHRAALRSVDEALYSAKTSGKNCYKLVTS
LSD
>A0A4R5J9N5|diguanylate cyclase|EC 2.7.7.65|Cupriavidus sp. L7L|TrEMBL
MTPDTAPPRHQAATVHSATPRRWQPLLLAAAGYFALAAAGLWLARLPGNVAAVWLPNAFA
LGLLLHRPRRETPWLLAGMLGANLLANHAAGDSAASALMLAGANLAEILCATGLLRLLDR
HAGLVRHGPLASFAVMLAVAGIVAPALGATAGAAAIVKLHGTPFASVWWTWWQASALGMA
LLLPMMLSMTPARVRTAFARPVLVPQASLLALCLAIGALAQWQGHDPFAAMSLPLVLVAL
AGNPFATALLTLVATLSLQALMVVGHGHEAVPLSAAVIMVFPVCIAYLTEQNRHGRASLR
GSEKRFRQAMEHSAIGMALVGMDGRWEIVNRAMTELLGYSGEELRAITFQQLTHPDDLSD
DLRQAALLVDGKIESYRMEKRYRHKDGQYRWALLAVSLVRDEDTGAPLHYIAQVEDIHAR
KLVQEELERLSRRIQLAVEAGGVGIWEWDFGSTAITWDARMHALHGTDPAQGTPQAEQWI
AMLHPEDVSRVSTEMRQAIRGAAPFDTEYRILRPGGAVRHVRAMATVTRGADGIAHALVG
TNWDITEQRRLTEALFEEKERLHITLRSIGDAVICTDANMHVTFMNPIAEQLTGWTMCSA
GGLPLEQVFRIVDEASGDPIPSPVESCLRTLTPAYLQDGAVLQSLTGERHDVQDSAAPVL
TAAGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLHGH
RAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYLIRNHVRPDDLLARLGGDEFALLLKDC
TVDQAEQVCQGVIDAIRGRRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAA
KAAGRSRVSVYRRDESDARRHHRELEVAAGIHSALEANRFRLFAQEIRALQPAGAGRGES
RHIEILVRMVDESGDMILPGAFIPAAERYDLMGHVDRWVIHNVLHGYGERLRAVPGLSVS
INLSANSLGEPFLLPFLHAELDASALPASRIRLEITETALINNMAAANRLVSEMKRAGCT
VSLDDFGSGLSSFAYLKQFPVDFLKIDGSFIRQLADNAVDREIVSSINDIGHRLGVKTVA
EWVEDERTLDALRAIGVDFAQGYAIGRPTPLDAFLQACGPRGVEQRQGA
>A0A7L6Z4M2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C15|TrEMBL
MSKPSQHVLVTLPHPLLRFVSLGLTAFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALACSLGSIGASLVLFPPSALNFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWLRLAFGSAVIPPLLGGILVWIMSPNETPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTLVVTLVLSWFAMKYVPWPFTLVIVLLMWSAVRLPRMEAFLIFL
ATVMMVSLMMAADPSLLVTPKVHVMNNLPWLPFLMILLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYNQDELRALTFQQLTWPEDLHKDL
EQLTMLVSGDINSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFELYEVPAHVKPTWSLWYDCVI
PEDREYAEKVVRDSLAARQPFKMEFRIAVKDGVRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPL
LTVLRITFGDNGPLMENIYSADMSRSAIEQDVVLHCRNGGSYDIHYSITPLSTLDGGNIG
SVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELAQLMLSMLRSSDVLARLGGDEFGLLLPECNIESARFI
ATRIVNAVNDYHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQV
TVYEPQQEQAHHERAMMSLDEQWRMIKDNHLLMVARGVASPRIPEARNFWLISLRLWTSE
GEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASKGLSVALPLSVAGLISTTLI
DELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFN
LMTKSLADYLLLDSELSASIHGNMMDEMLVSIIQGHAQRLGMKTIAGPVQTPIVMDTLSG
IGIDQIYGDIIAEAQPLDLLLNTSYFAIN
>A0A7L6Z6C5|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB20-C15|TrEMBL
MDKDLSPTPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQRNLELTAATMT
HSLEAALVFADDAAAAETLAALGQQGQFSAAEVRDNNQNVIASWRYNALENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRAVRSIK
>A0A8G0FS95|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MKGIRLLACCGVRICSVILLVISSSAYAVVEHISDYFVETWTSTDGLPHNSINSIAQTRD
GYLWFATWEGVVRYNGINFQVFDRSPQTGMADSGTRTLLPMDNNGLLVAGARGSITHRQN
YGWQSLRSAPSLVNSALIDDAQNLWLAIEGLGVLVRPYLGNNLYGPDRWLLTDASVYRLV
KNQHGVIFAATDKGLYRFNHWQASAIELPIGRYERINYISISLNQELVVATDHGVWINTE
ESFQSLFSPLEKDVVTLVEQDRAGNWWIGTVNRGIARLKNQQLQFLEPSRGLPDSRVLSW
YQDIEGSIWVGTNAGIMRLRDAPFININSDKGLVGDYVRTLLPLDDRRVMVGTSRGLSIL
EDGLAHSALTPDASIHPSILSLAKADQQNESVWIGSVQKGLLLWQNGQLRSVLDENNGLP
SSEVRAIVTDVQNNLWIGTQNGIVKRTPKGMLTTYNKKNSQIPDDYIMALAIDAKGQLWI
GTAVGVAYFDTEGKIRSIDLTALEQAQYVFGFYVEPDYVWMATDRGIVRYRLSDGSLSLV
GRSAGLPIDKFFQMLRDSEGNVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGDGM
ATSQANGGTNPASASLPNGQLLFATAKGVASIKVQRLQQLSELRLPVVLESVSFDSESIN
PDQQYIAAAGTNRVSFGYVGLGFVMSERLQYRTKLEGFDQDWSYRGHSTQAEYTNLAPGK
YRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIFMAGMLLLALVASLVMWRIRMLKR
RELYLVEQVALKTQKLRLQAEKFERLSKEDALTGLANRRAFDMYLKQAFSRLQHPDQQVS
IALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYVGDKTRVARWGGEEFTILYLGDPRL
AWGYFEKLRCKIEQVDLSAVAPKLKVTVSIGFADAQQAESYETVLKLADHALLTAKKLGR
NRVVKSEEW
>A0A2D9W485|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp|TrEMBL
MPRLSVEQLSQEWSLLNQRFSAQSRRFVLSFCTRHAVDLTEQFYSEMLADPAAALFLSHD
QVQGRLSQSMRRWLEGLFDAEAEGGLARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIELLHEDRELSDRDHLDAARLMSDTVDLAMEIMSHAYSASHDRNSRNEEAYRLFSVTQN
IAAEKETQRAALFDWENQLMFDQAVGQPGAHLPRILASEFGLWFRHKGAHAFEGSREAGQ
IIEAMEQIDDVILPLFDGDAEERIARLRELRETVKSIRFNLDNLFEQNNALEAGRDVLTR
LLNRKFLPVVLNRQVSHARTHGTPFSVLALDIDYFKRINDSFGHDAGDRVLQQLATVLVN
SSRAGDYLFRLGGEEFLMLLVDTDLNGARRTAEKLRASVEREVFRLPQERTLNVTLSVGV
ACFNGHPDYQQLMRRADEALYAAKHGGRNQVVVAE
>A0A655UJY5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLLNAFSRRVLLWLGWLLISTSSLAATSTTYKVATEADDVVTRVLFDSIAHHFNLEIEYV
NYPSFNDILVAIETGNADFAANITYTDLRAQRFDFSRPTNIEYTYLYSYGGLRLPELRLV
GIPKGTIYGTLLKEHYPYIQQVEYEGHLEALTLLESGRVDGVVDAINQLKPMLLKGLDVQ
LLNDQLPIQPVSIVTPKGKHSALLGKIEKYAHSAHVQRLLRESIQKYQLDIRKQALRQAV
VESGLNVQRVLRVKLENNPQYALYQPDGSVRGISADVVFQACEMLLLKCELVSNGQETWE
SMFDDLQDKSIDILAPITVSQQRKNLAYFSESYYHPQAILVKREHYKDDVYSNVSELVAE
RIGVIKDDFFEELLQQMLPNKILFSYASQEEKVQALLNKEVDYIVLNRANFNLLLRESTE
MLPIVEDTMIGSFYQYDIAIGFAKNPLGATLAPLFSRAIKMLNTEQIIHTYDYQPNWRAT
LLAEKKYQRSTQWLFAMAFIVLFMVAFYLHGISHTDNLTKLRNRRALYNRYRRGLSPRLS
LVYLDVNTFKSINDQYGHEVGDKVLKQLAQRIEAEWRGRSYRIGGDEFILIGECSAKRLE
HVVAQCERFMFVDAERDVSFEVSVAIGIAKNRERTESLNEVMHQADIAMYRSKAESTQSP
FQAASKVKGLHIV
>A0A200L4A2|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
>A0A7Z8BHU7|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MTAEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVD
ANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTR
HVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQ
MQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEE
FVLLLPRTPLDTALSLAETIRVSVAKVGISGLPRFTVSIGVAHHEGNESIDELFKRVDDA
LYRAKNDGRNRVLAA
>A0A7Z8FIQ0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8B3KMD0|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A0K0Y5L2|diguanylate cyclase|EC 2.7.7.65|Octadecabacter temperatus|TrEMBL
MTKSEAIDDGELVSQSLSWRDSQETDDAGLMLATQIMNVMEQGIILWSADGTCELHNTRI
YEVLELERSALGIGTNRDEFLAAAVPRGEYTDEKLAEMRKHSNTRIAYQYDRKLPSGDVV
ECHARPTREGGYVVTCTNVTEARQAARELAAAKKAAEDAESKSSLILQEERARRAEARTL
SDLDEWLQSCKSLDELFQIVAKFMGYLLPDSYGELYLYSNSRDVLDGACEWGQEDAINAH
ITPDSCWSLRRGRVYEHNPDALCFPCDHLSEQSKATLCDYICIPIIAHGDTVGLLHINFK
AGMSRAEIKSLGRFAARCGEHISMAIANVKLRDELHDQSIRDPLTGLYNRRYFMDAMRRE
TSVADRGGKGFSLISLDADKFKTFNDNHGHEAGDLVLRALAECMLAVLPSSAVCARVGGE
EFAVLLPQCIENEAMQQAEALRSSVSEIEVRTAFGLLPRVTISSGVAAYCGDSTAPSVVM
KRADEALYAAKSDGRNCVRLAKTGTREAVTPVHS
>A0A7Z1D6C4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRNEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCTLARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A7Z8BG66|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIYSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRELNKEGEVERLLGINIDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANLASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVTSKGLSIALPLSVAGLSSTTLV
NELLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKV
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7Z8BCR4|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLTDADNAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDML
IPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLA
LVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQ
PDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVYDVLAHLQN
LVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVSLFALRNGM
PIHWASSSHGAEIQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVADISQHMAA
LALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVDHIQDVIDS
LGYAWADQALLEVVNRFREKLKPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSK
PIMIDDKPFPLTLSIGISYDLGKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVKE
RLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEE
IGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLSNQVSDAMHAWGID
GHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKID
KSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSR
PLPAEEIPGWMSSVLPLKI
>A0A7Z0SQS8|diguanylate cyclase|EC 2.7.7.65|Halomonas sedimenti|TrEMBL
MRYKDKHQLAAEWQALLERTPKPLRQAVETLVEHYCQKFADHFYQVMLEDPHASLFLSND
QVAQRLNPSMRRWLKAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAF
YEQINATFKSPLSPGDASVYVSDHIDMAMEIMSHAYSVASDRNARTEEAYKLFSLTQSIG
DERERQRSALLNWENALMFAIAAQQNVATLPRLSNSDFGLWYFHKACHAFEGVPEIATIS
HHIQRVDREWLEALQHEDINQRLKALGEIRDAARTVLMLLDNVLERASGLDAGRDSLTRL
LNRKFLSVVLSREIDIARHSEHCFALLMVDIDHFKSINDTHGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIVLVNTDHDGSRLFAERLRQSVAKEPMLAGADMLLNVTISVGVT
LHDGHPDYHHSLQRADQALYEAKRGGRDRVVVQ
>A0A7W3A7J4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RHBSTW-00901|TrEMBL
MNKDFTPKPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HNLEASLVFNDSLAANETLATLGKQGQFAAAEVLDNHKKRFAYWSWDPEDNTDTLGALIS
RWLFPEPVSQPIMHNGNAIGEIHLTARDSLISHFIWMSFAVLTGCILFASTVALTITRSL
HHGMVTAMQNITDVVHDVRTNRNFSRRVKAGRIEEFHQFGEDFNSLLDEMEEWQLKLQAT
NAQLMRTAMHDPLTGLANRAAFRNSIAALMNDASAKANSALLFLDGDNFKYINDTWGHAA
GDCVLIEIASRMVEFGDKRHLSYRLGGDEFAMVLYGVHSEPEVQRICAALSQQFTRPFDL
HNGRTALMSLSIGFALAWENVSVEALLEQADRNMYMVKNQRTKTIY
>A0A4V0B5I1|diguanylate cyclase|EC 2.7.7.65|Gordonia terrae|TrEMBL
MSDETSGHRDLYDDADHVLEQVRMREWHVRFTIAVLVAVCGVLGTIALLTPSGTQGSVPR
SIALGIVVASTIPMAFVVSRVHLGVIWWTKQSSVRGFNTAFVLWADAVLTVALVAITDIV
LAQFCAVIFAVIGSYVAHFVRSVVAYAHMIYSSITVCALGIVSWSDGTPFMNVLFTSLAL
LVATNGTTALHRSYTSDFQRSLKHQLIMANTDSLTGLLNRRGFIYAATTMLRRNPAVPFA
LIAADVDRFKGINDEHGHATGDDVLQRVAEILQGAKAEHAVVARLGGDEFAIATLADEGS
VRALAERIRTQRITTRGGATASISLGIAVGVTPGGHMSSDDADAFIRGEFDVADEALFDA
KAAGRGTYVVAGRSTSGPPTGARPDSADRRGREPA
>A0A7C7P9A4|diguanylate cyclase|EC 2.7.7.65|Methylophaga sp|TrEMBL
MAAVIHQQLRFVIDEIDKAIESHQKWYQDLLRVLVSRVPPDEKDLRNDAYKLCEFGEWFY
TSHVELIQDHPTFVSLGHAHENMHKSAKQLIELVVSEQAIPVTMFDEFNHDLEKMRTQFQ
ALRHEFANLVQNLDPLTGAQTRAGMQAELNKEHAMAKRSLQPSALAMLDLDHFKQVNDNY
GHSVGDDVLIKTVACLQQVLRPYDQLYRYGGEEFLICMPNTTLEQAERVAERIRSMIAQQ
QIIYDKEGNTLQVTASIGVTSLDPAYSVDDAINKVDEAMYQAKTAGRNLVKVR
>A0A2R4D8L0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Concord|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5P9IX40|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MSLGVTLQRFFQSLVLVWAVFASHLASASITDYVVKQWNTRNGLPSQSLKSVTQDNKGYI
WVGTQFGLSRFDGDHFTNFTQQNSNFLNSNAINKLLIDKEGLLWIGTKRGISVLDPDSMN
YFEFGIGGPVRDILQDDKGNIWVAANELFYIERNQVAFHLPESERRRSGRIQGRLTAINQ
ISVSKMALAPQGVWLVSENYLLRLTNMSSSSSRLRLKITARVTLPDRLAQTIIHDLAWLE
GTLYLASELGAYFLDIDDELRPFTLPNASNAAVYKFMSDSDGALWISTYGRLLYRDNSKE
WQWVEPAALDQSIWFSDIYRDEQNNIWLASFSEGLWLAHAGRVERHNALSSMTEAVMAIT
LSPSGQLWVANRSGVGYFDQDNNFINRVPRAKLRRSAVHDLHFVGERLYIATDRGVLYFE
DEQLYNIDARELRQNPVFAISESSAGGLWFGTGRGMYRMGYRGLTPFTYNAVLDSKFITY
VLDKGKYGLIGTSQGGYLFSDKGIERIGDSTALESAYVTSILEIDDVGTLVGSLNDGLFY
RSTQGRWHQLDVSNGLPYGSIFSLHHDEALQRVWVSTMKGVYRMPVEQFSDEIGNLQVEQ
VISSYDRQLDGKASQCCAGLGHDAVADSGDSIWYPSLQGVVEIPKNVQLFGQDQLAPQVE
SIATPRRTLYTGGLGVNPELDTDERDLTINYTAIDFYAPAEVEFRYQLSGLDTDWRYAKN
RREAIYTNLPPGPFTFKLEAKRTSDSWEEATSTHYAFQVPKRFDETVYFRLLIVSGLFFI
IYLLLWVFRAQERRKQAALESLVEERTMELRDANDKLNQVNSQLKLVSHSDELTGLRSRR
FLFDQLPKDIEHYQRNSSSLQEQGRALVLLIVNIDKFSRINDAYGPLSGDSCLQQMATLL
NSCTQGSDYVARWSGDEFLLLLRDFELDQVNQFARQLCKSIAEKSFQLPNGKKINLSASL
GWSCYPMPLLGGQVIGWETSVNLADIALHQVKKRGGDGCAHIEFDDQLDAFEFEQSENLD
AQIATLQSTGLADIKIWMR
>A0A2R4DCX9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Concord|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A737Y0D2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 30:1,z28:z6|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLETTLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTS
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5P9IXT8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MMFHDSMANAQEKMTQVCHLLELHALPPTPLNYHVLYQHVSEGESALSEALQAAVTEGRI
IDSVLMEELYIQHLTPDHQKQTAMVERISELIGNLERNSKSNQKHIDHYHLEIDRCARAL
DEHDVDKSRHQLRKLAEHTLVLKGQMQKFKQLLEQIKQQYLSTKSQLKRLKDKHHLDPLT
GLYHRHYLDKKFQYWAKKQHQISLIRIDVENYQQFCHDYGDSIGNLMLEKVATKIDKYVK
ESGFCGRTQNEQFTIMMADVEAQTVDLIAEKVQAGISKLRFVSSRSGKQLPGVAFQCQTI
HRQQEPNFSALVSSTH
>A0A5P9J1X8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MQKLPSNTHSAEGIFEQVEELKFKIIVRVAIFAAAIHAALIPGFYVIGATPLAILNIFST
LSWLLGIWLIKNNRQSWGLRVVSVEVVVHSIAACAFMGTETGFQFYLWSVSCILMVDYKM
RMGSAVGFSLTLIAIFAAIYILFSGVAYPYAYGEFLRYIEVANILVAGVPMIYTLALIRR
ITLEQRSTLADMAAKDFLTGLYNRRFAKELMLKLHNRCSTAEQPMCVAIGDIDYFKQIND
QYGHEVGDKVLVALSQTLLEHTRASDVVARWGGEEFIIALPNIDIDTASARIESIRSAIK
TMDARQVSPELSLTMSFGLSQWQPQQSVEDVINVADDALYRSKSNGRDQTTLAASAPVTL
TQVT
>A0A653KLE2|diguanylate cyclase|EC 2.7.7.65|Aeromonas salmonicida|TrEMBL
MDVLHTPIWVYDIRHHHIYWANRTALGVWEASSLAELQARDFSADMAAAIDLLLQRYLGD
FQQGRSYSEWWTLSPRGIKKQIYLRLSGIQLAGRLMMMTEAVIDADTLYQESSLATGDTL
ACLFDNQGQLESGNHHFDTCFGDQVSQLSQVFSGNNEAFYQKLSRLDEVVAEGECRTRKG
MRWFQYQFRHIQQGAQILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEAYC
GMSGRFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQVCPRDVELARLGGDEFTAL
VPLAHSSDRAQEVADLMLSQMTKPLQLSGVPEVTIGGSIGIAIYPDDADDGDTLITRADM
AMYQAKQMGRLRWQRFTPSMQQTLHRKLTLKQFLAKAIGRQELSLCYQPQVDVAQGKLIG
FEALLRWHNPVLGHVSPVEFIPLAEEMGLIREIGSWVLSTALAQMAHWQQACQVRVPVSV
NLSGFQLSTSLPELVAQQLKAYGVDASLLTLELTETVLMLDMKGCIEILDGLSEQGIKIA
IDDFGTGYSSLAYLNRLPIDTIKLDRSFVVGLNLPVIRATVAMATSLGLGIMAEGVEDEH
ELAALRAQGCHVFQGFLFSKPMTVAQVEENRFAVCCKAGTYPLAE
>A0A381GAX4|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MDKDLSLTPRPTFKRALRRINITSVIVTMTLIWLLLCVASVLTLKQYAQRNLELTAATMT
HSLEAALVFADDAAAAETLAALGHQGQFSAAEVRDNNQNVIASWRYNALENDDKLGDFIS
HWLFPFPVAQPVWHSGEIIGEVRLTARDSLISHFIWLSLAVLTGSILLASGIAILLTRHL
HRGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHNFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSISALMNDNSARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVARRLAEFGGNRHIPYRLGGDEFAVVLYGVHSDYEVQRISAALSQEFNRPFDL
HNGHLVSMTLSMGYALTWEHASAEKLQELADRNMYQAKHQRAVRSIK
>A0A6N2S322|diguanylate cyclase|EC 2.7.7.65|Citrobacter amalonaticus|TrEMBL
MPHEATMENGGWLKTLARRLGPGHVVNLCFLIVMFFSTLLTWREVVVLEDAYISSQRNHL
ENVANSLDKQLQFNVDKLLFLRDGMHEALITPLGFSVLRDAVTHFEQLRHSRVWQLELDK
RRTLPLNGVSDAFVSQTQLLSRDDQSLNNELTAALEVGYLLRLAIIRTSMSQQAMYVSRA
GFYVSTLPTSLSSDITTRYYHYVIQPWFTEQSQRKNRMRGVRWFTTPSPDLSYEQQRVTV
SVPLDYHFYWLGVLAMTIPVSAVERFMDEAIDKDVEGVYQLYDSKLKLLAGSSAELRNAN
TFDERELAMLAHDIEQDTVGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVHGDFGSISI
ALALLWALFTAMLIISWVVIRQMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKAKHLT
QRCRTQKQPLSVIQIDLDHFKSINDRFGHQAGDRVLTHAAGLISGTLRTYDVAGRVGGEE
FCVVLPETSLAQAEQIAERIRLRLNEKEILVAKSATLWISASLGVSSTQETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCVSDKG
>A0A6I6E0T7|diguanylate cyclase|EC 2.7.7.65|Leclercia sp. 119287|TrEMBL
MNRKFKEIDETVRGLNQSTDAHFKWLVKLLRFIDSRNVDLPEVSSEEAHLHCEFGHWLNT
RLLEEREDTNFLLDINKKHIHVHQACRRLISAIEQQRQRNEDFDLFEQSLLAFTDALTLY
KVHLLQLRTSYDALTGLPLRRILDESFGSMNKELGASGLYLLLLDIDHFKKVNDNYGHLN
GDIVLRSLALNISNNIRRSESMYRYGGEEFIVLLHATHDDEAVIIAERLRRDIARLETIA
GEHIIRITFTGGLTRIHQGEVLREVLERADIALYTGKKSGRNCTQLINRDLETQKFCD
>A0A365TMC0|diguanylate cyclase|EC 2.7.7.65|Halomonas sulfidaeris|TrEMBL
MRHKDKDQLAAEWQALLERTPKPMRQAVETLVESQCHIFADRFYSVMMEDPHASLFLSND
QVQQRLNPSMRRWLSAMFSVEHADFEALVDLQEKVGQVHARIDIPVNLVLSGARQLKQAL
YEQINASFKSPLSPGDASVYVSDHIDMGMEIMSHAYSVASDRNARTEEAYKLFSLTQNIG
DERERQRSALLSWENALMFSVAVQQNVSQLPKLANSEFGLWYFHKACHAFEGAPEIITIS
RNIHQVDNEWLDALAHSTTTESMKALSNIRDATRTILMLLEDVLKRASSLEAGRDSLTRL
LNRKFLSVVLSREIELARHSEKCFALLMVDIDHFKSINDNYGHDAGDNVLQQVASILDRS
TRGGDYVFRMGGEEFLIILVDTDQDGSRLFAERLRQTVAKEPMLAAADTLIKVTVSVGVT
MHDGYPDYQRSMQRADQALYQAKRSGRDRVVVQMG
>A0A447JGI0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Daytona|TrEMBL
MLFSTLLTWREVMILKDAYVASQRNHLGSVANVLDRQLQFNMDRLIFLRNGMHEALVAPL
AFSALQSAVTQFEQRRVRHFWQLELDKRRTLPLYGVSDQFVARTTLLSRESRDLANELTA
TLELGYLARLARSSAMLTLETMYVSRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQ
RRNPQRGVRWFTSAQSYVADEQKKVTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEK
DIEGAYQLYDNHLRLLTDSAPEQQTANTLNDRERALLAREIEKDTLGGLRLGTHYVSWER
LDHFDGVLLRVHTLREGIQGNFGSISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNS
LQWQAWHDPLTRLYNRGALFEKASRLAKRYREARQPFSVIQLDLDYFKSVNDRFGHQAGD
RVLSHAAGLIGSTIRAHDIAGRVGGEEFCIVLPGATKAQALADCRTHTPAH
>A0A3T2UV37|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRQDAEVIMKLTDAENAADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEV
IGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSA
EGKVYYLALVRDASVEMAQKEQTRQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYC
ISEASGMQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPVY
DVLAHLQNLVMTFSDITEERQIRQLEGNILAAMCSSPPFHEMGEIICRNIESVLNESHVS
LFALRNGMPIHWASSSHGAEVQNAQSWSATIRQRDGAPAGILQIKTSSGAETSAFIERVA
DISQHMAALALEQEKSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVDKAVSPVVYLIGVD
HIQDVIDSLGYAWADQALLEVVNRFRGKLKPDQYLCRIEGTQFVLVSLENDVSNITQIAD
ELRNVVSKPIMIDDKPFPLTLSIGISYDVGKNHDYLLSTAHNAIDYIRKNGGNGWQFFSP
AMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPQHGHVPPS
RFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSALHFRSNQLPNQVSD
AMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSL
PVTEIKIDKSFVDRCLTEKRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRV
IQGYFFSRPLPAEEIPGWMSSVLPLKI
>A0A658YTJ0|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALP
VDDVWGIGRRISKKLDAMGIKTVLDLADTDIRFIRKHFNVMLERTVRELRGEPCLQLEEF
APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALN
EPYYGNSTSVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNL
FDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLR
VK
>A0A380AH30|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIWVLSESIGALALVPLGLLFKPHYLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPF
TFIIVLLMWSAVRLPRMEAFLIFLTTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLI
LLPANIMTMVMYAFRAERKHISESETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLG
YSQEELRGLTFQQLTWPEDLNKDLQQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSL
VRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDK
RMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHI
RALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMK
ITFMNPAAEKMSGWTQEEALGVPLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHC
RNGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASF
EKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDV
LARLGGDEFGLLLPDCNIESARFIATRIISAVNDYHFIWEGRVHRVDYLD
>A0A5A9DB74|diguanylate cyclase|EC 2.7.7.65|Citrobacter braakii|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYHIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A3S4KT43|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAANPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A1H8QM25|diguanylate cyclase|EC 2.7.7.65|Rhizobium tibeticum|TrEMBL
MQPNTHTNLAFRVATVLQQLGIEGLPRNYELVFEAMTGNSPDLARELRSLGPVKTQDALD
AICRRYLPHHFEGSLLEARSGQVQQELQSILSLLNEEKSALTRCGSVISQAARIFEANDV
TDKVALTQSLQSVSSATHAREAQSSMLASKVVEKSQKLEEVQRETAATNAARFVDTLTGL
GNRRGFNKELAKIYEKSGLPDLCGIAFADIDGYETIAAVPHLLEPVLKKIGELIQQISSQ
EDLACRFDRGRFGFVFRTADETEIMRLIDRLRDRIKGLPVVHPVSGKRAAALSFSVGICM
SREALTADALIAFAEQALAMAKASGGDNVSIHGVANVSHVPKDWLIYR
>M1N448|diguanylate cyclase|EC 2.7.7.65|Clostridium saccharoperbutylacetonicum N1-4(HMT)|TrEMBL
MYKYMEFYEHIEKLKKDENYIQYFRNYAIKNMMSDFKYVKEVLEYILELTRKWKYKFAEH
WCLTYIGWCENCANDFLKASTTHLIANDFFEKEQCVEGIIVSCNALLSDYLNLGELELAI
RNGMRGIELATEEEDEKNLVSLLLNTAETYVESENYDEALDLVERLKNDNYNLAPESEVV
ILSVLSKCALYNGDYNEAYEYCNTALTIMNGINYIIDREEFMGTRALINYRVGNIEEAIK
EFEEIIKITTENNDSFYKIKTAIRWAKCYFNLKQYELAKEKLFIAINDENLASYIKFRVQ
AYEMLKNIYSNMGDFEKAYKAFEKYDEYKKEANTNHSNLCLSILRYKSAAKEAKTYKSLY
KKMDLISTVGRKITASLGMKQLVRLIYNEIGKVVAADVVGVGLYNKEKNRLVYETFIEKG
EEVEYKELSLDNKASLGVYSFLTKKEVVINDIVNEYWKYVDILPLDIERIDKYPASIIYL
PILLEDKPIAVLTVQSNAKNVYASSDIFALRILASYIAIAIENGKLFDEVNYFANNDMLT
KILNRNKIIRQGEELVRNRSKTNSKLSIIMMDVDYFKKINDTYGHYVGDIVLKGIAKISK
KQIKDIGFVGRYGGEEFLILLPKLDLENAKKIAELIRETVEKSEYEIKDGIYGKVTVSLG
VYEFSESDQLLIDGLKKADMALYKAKDMGRNISVSFDECKESDGN
>A0A6N3GLM7|diguanylate cyclase|EC 2.7.7.65|Enterobacter agglomerans|TrEMBL
MKAPATPENETDRLHSLRESGLLEIDSSPAFDRLTRLAKRFFQVPLAMVNLIDEHSLIVK
SADGQAPGSVPRNISFCGHTILAEAPLVVGDMRQDDRFADNPLVAGEPGVRFYAGFPLRL
RDGASVGSLCLIDYAPREFSAADLAVLGDLGALAEDEFAAISAATTDELTGLFNRRGFNQ
LVRFTLSIARRRAEPLTLGWLDLDRFKEINDRYGHEEGDKALKVMAQLMRTSFREADLLV
RFGGDEFAVLFADTDEQGAWIAMQYLAEQVENYNARKLHPWSLKFSWGLSEFDHNSNDLQ
KWLNDADAKMYAMKQQRQRGR
>A0A1V4W035|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin013|TrEMBL
MADTNWEGDSALIATLRDVTDNVQLREKLISISLTDELTGLCNRRGFLTLAQQQLALANR
SKGEVLLLYGDLDDMKWINDNFGHHEGDRALIETANILKSTFRESDIIGRIGGDEFAVLM
LEAPVSSAETLITRLREKLAGRNAQTVHYRLSISVGIVHYDPESNYTIDKMLIEADKLMY
EQKRDKRHLTGEKSIYEQENN
>A0A839W675|diguanylate cyclase|EC 2.7.7.65|Azospirillum sp. OGB3|TrEMBL
MDSQKDRKAAILAATLSSLWTDTEPAVRERVTAIALGDADAISDVFYAILLDRPDSNAFL
SHALVQERLRPSLARWITALFTASSDEAIAAVLEQNYQVGLIHARINIPLTLVNAGVRII
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISAKVSAAVEGGWVTPAFVKELNNDVTEIAYVLGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKAERLRRTVEEHRFSGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A1C3JE17|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MKRLVGRHLEEMADIRSTRKQKIVHSFSLTAAALFIFYTWAYFQGEHYTLSIFELCFAII
AVSNAFYVRKVINPEYSELILSGVLLVQGVILFLYSHAIPDRILWLYPILAAVIFINDFR
IGIIFSTSFCLFISTLITAMPNNFSLPFNSTHRFVLSLFTMSLVCHTSAYYYTKAVSYIQ
RLYKEGIEDLAYRDQLTGLANRWSFERWATEKLATVDSERSLTALVFWDIDDFKGINDSY
GHDVGDSVLQHFANRLSNNIRTRDRKSHEYDYSIARFAGDEFVLMLYDIPTRKDLDGILD
RICGLFESGCQTNERIKELTLSVGVALYPQDAQELHELTRCADKAMYVAKRSGKNRYAYY
HDNPVSTLIEELPTSLVSSAPGSSELEDCFEAKIKGNNVTLLKARQR
>A0A011QLM1|diguanylate cyclase|EC 2.7.7.65|Accumulibacter sp. (strain BA-93)|TrEMBL
MSSHAEQVTPRTDVSDGLSGVMEPWHQEALLKAGALQNAIFNSANFSIIATDAKGVIQIF
NVGAERMLGYAAADVVNNITPADISDPQEVIARAEALSLELDTPITPGFEALVFKASRGI
EDIYELTYIRKDGSRFAAVVSVTALRDDQNEIIGYLLVGTDNTARKEIEAEQQLLGQRLR
DHQFYTRSLFESNIDALMITDPSGVITDVNKQMEALTGCTRDELIGAPFKSHFTDPKRAE
AGIKLVLLKKKVTNYELTARDRGGKETVVSYNAATLYDRDRRLQGVFAAARDITEHKQVQ
AEILNLALYDSLTRLPNRRLLNDRMGQTMAASQRSGRYSALMFIDLDNFKSLNDTRGHDV
GDLLLIEAADRLKHCVREIDTVARFGGDEFVVMLSELSVENSESTAQAGVIAEKIRAALD
RPFVLQGRQKGTAENTVEHQCTASIGVALFSKRDASRDDILKWADKAMYQAKEAGRNLIR
FYEPTA
>A0A128FG66|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MELSLSYYKAQLGELLTAKHHASAFSTTRATYLRIRIVALCYLWAALCILWIPVDALLLD
QASAPLAILRLKLSAVLFFIGWLTSQRSTLNACRNAIFALVVSLNLFYMLTNHALGYPHS
IDAFSYCYNLLPFVYVVILTILPLTVKESVCVMLIIAVSQIYVDAQSGALLSFETFTLYW
LQTVIGFLVIWTQTSKLHMMLRLYRHATLDPLTGIYNRRMLLTLAKRDFENTRTKSRPYS
VLLMDLDRFKRVNDRYGHHAGDIVLQAFTQAVQETQRKSDIFGRFGGEEFILFLPKCSAD
NAQHVANRIMALIRDMRIEVEGLSEPLKVTISIGISTSLCKDDDLSVILEQADQALFKAK
NSGRDQSSTYDRVDELIEEGQKRPWLELVN
>A0A370HJW6|diguanylate cyclase|EC 2.7.7.65|Microvirga subterranea|TrEMBL
MDMTIKVLDAPTRAAQIISTTGDGVRAAVAGIVEGHKDDLVAVFYATLIVDQEASRFLSH
DLVNERLSLSLKRWLNDLYGNGTPDIEAFIERQKMIGDVHARMRIPIHLVMQAANILKVG
IFRRLKDTTLPRADLWAAVVYTNSLMDLAIEIMSQAFVNGTASRVETDEAYRLFSLGQDI
SLDKETQRAALLEWSQSVLFAICAAEREVLLSPISASDFGLWLHHRASVLFQGSAGLARI
EGSMRLIDGELLPQLREARAADPARLTTLLERFQAIISEMKFLLSDMFQAAAAMENGRDP
LTKTLNRRFLPSILGREIAIANESDKPFSLLMIDVDHFKQINDSWGHPAGDAVLSQVAEV
ILDACRLSDFVFRYGGEEFLVALVETDGKAAYRAAERIRKAVEGRTFLAPDNSPLPVTAS
IGIATFDGHPDFNRLIQAADQALYRAKKLGRNRSASAEAPVLDKAG
>A0A0J6W3N4|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MDKGLREYLLIWWRQPFDYEWTRRHLQSRGLMRIHQLFIGSFTLLYGVTALLTVVWAARD
GGAVNGRPLVIAVAVSSAIVGVIWIVGPAPTERQSRAFAIYADLGTIAVIACYQDAFTAM
PGLALLAANGIYIVVLHGPRALAGHLAFTVMAFAVMYGIALAQGTNATSVVTIRLLVLLP
TVIGVQVIVQSYLLALRMGAVDSLYDPLTGLLNRRGLEDEVAGLVSEDGAHLGVLAVDID
KFKTINDGHGHDVGDAVLVAVANAIRSAVAAADVRSLIARTGGEEFAVVVLGPPTAVRSV
AAQLHDAVARCGAAVVPTVSVGVATAWSTDREASSTVRSLLELADGAMYRAKSVGGNQTV
VVGDGLAAEH
>A0A0J6W8G9|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium obuense|TrEMBL
MGVREFAFATRALREGRMMGAFTRFIAMACFLLAMLCVVTAVIPMGPDTIAGRAILLTVA
VSAVLMGLRWLFTPWPTHGPAVVFVVWADVAVALLSMVMSTPEARLSSALYLGLNGIFAA
FLLGPRVLLAHCVFGAVVIAAITVEGMSSGAALWDLGMFALPALAWVVFVPLAGCVLITS
GRRALRATVRSAESDPLTGLWNRRGMLSAFGRAVRNVSEPQIVAVAVFDIDKFKQLNDTH
GHTAGDGALIALAQRLRAMAQPGEIPARIGGDELMLVGLYSDTDDIDDLMLRLTPLTRSA
EGDLTVSIGVASERTDEPHFLVDDLVRHADTAMYRAKRTGGGRCSVYGRPEGNG
>A0A5Q0DQU2|diguanylate cyclase|EC 2.7.7.65|Alcaligenes faecalis|TrEMBL
MSQPNIEEAAQDWHGLLQKVPLAVRAHVLTITQDNQDELATHFYTHMLKHPAAQVYLSHD
QVHKRLHRSLRSWLVQLFSVDEHSDMQDQVKLQNQVGEVHARVGVPVHLVLRGARLLKGR
YARFLFESSTISSEQAWECYRYVQNFIDLAMELMSHAYANSRERKSRAEESYRLFAIVQN
VAAERGRQRAALLDWENLFMFAMAVNNGVTPAPRIGDSDFGIWFKHKGAHAFQGTVESRE
ILDLMNMIDTELMPAFEQGDAKGQVLRLHELRDRTRAIGLHLDRLFEQQNELESGRDVLT
RLLSRKYLPVVLSREVGYAQQRGSRFALLAVDIDFFKRVNDTYGHDAGDRILRQFAELLS
NSARAGDYVFRLGGEEFLLVLVDVDADGAMRAARNLRLRIHAETFRVVDGESMNITASIG
VALYDGHPDYERTLRRVDRALYQAKEEGRDRVVYV
>A0A829DN22|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2875150|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1A8TUG7|diguanylate cyclase|EC 2.7.7.65|Marinomonas spartinae|TrEMBL
MKNTSSGPSMLSRAVFGRLLLLAIVCFSVVWIIDYNSGIIASFDAFAYPICISSFSVVYL
LTITKKAPDQYLHLVTYSVVAGYLIASSIWHHMATNGIFSNAAQWLGLNYVIAYLFLEVR
KAILMTILAFSVTVIGHFIALIQHYSIEDTLGVVLNIAVAHIVYIVLLWTVIQLRSSENK
AQQQVSMLEHYAYIDPLTRILNRRGLEKVTQELEQEFHLGQQEFAILLLDIDYFKDINDR
YGHLKGDDVLTNIASLLSRKINPKDIIGRWGGEEFIIYTMNQSRKEIFDYANSLRELVSK
LVIGGITVTVSVGVGYSQPDKGLSDIFYLADQHLYAAKKAGRNTVVDRISNSKESENGKA
GLLVS
>A0A1F2ZUJ8|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. RIFCSPHIGHO2_12_41_5|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALRFIAEVLLDVA
KGSDYAFRIGGEEFLLLLVDSDLTRALQIAETIRMRIQETLIRTAHGQSFSFTVSVGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A8G1HYD4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. ERGC3:05|TrEMBL
MSDLQIDDIKTDENAAMVLLVDDQAMIGEAVRRGLAHEENIDFHFCADPHQAIAQAIRIK
PTVILQDLVMPGLDGLTLVREYRNHPATANIPIIVLSTKEEPLIKSAAFSAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYLELEWRRAMRDQTQLSLLMIDVDFFKTFNDSFGHVEGDEALRKVAAAIREASSRP
SDLPARYGGEEFALVLPNTSPGGARLVAEKLRMAVAALKIPHIAPAEGSSLTISIGLSTM
TPQQSSDCRLLIMAADKGLYTAKHNGRNQVGIE
>A0A7W9L588|diguanylate cyclase|EC 2.7.7.65|Brevundimonas vesicularis|TrEMBL
MSARILVVDDVDVNVRLLEAKLTIEYYDVLSCNDGLSALAIAAEHQPDLILLDVMMPGMD
GFETCRRLKAQAETRHIPIVLVTALDGREDRIKGLEAGADDFLTKPIDDVILFARVKSLT
RLKHVMDELREREESGRRLGVDSDNAARLRSEGGRVLIVDDDQRQAEKIAQELGGEHRVT
IETDPEAALVSAKGALDLIIVNVAAASFDGLRIVAQAKSGDARRAPILAIVEPTERPRMI
KALELGAADILPRPVDTEELSARVRTQIRRKRYTDFLRQKLDSSMEMAVTDALTGLHNRR
YMTGQLQALVGRAAQGGAQVAVLVLDIDHFKSVNDSFGHDAGDEVLVEFAVRLATNVRAV
DLPCRMGGEEFVVVMPGASLEDAGRVAERIRRDVASAPFRVMGGKEQITITISIGVAATT
GDGDTPEGLLKRADEGVYEAKAAGRNRVIAKAA
>A0A380WMS1|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MLDFGSLLLATALSGACLSGTLVAIWLTARQSRFVLTMAVGILLLVSHVIAFWLYGQYAS
PWLGQGMLALLVAGFFVVFTSADQYIERGWSKPAALPIIAIIALTVVVTAAGFDGVGFVI
AYSAVTAILVMTATAFWTSTEVDRRVLAPVSLLTGSSAISFALCAFVIVQQKQWVLGTVP
RNWAEDVNTVVVVACMTALGALTISFHHLRTQSRLTEETLTDPLTGLMNRRALSSLHDGT
RFSPGMALAMVDLDHFKRTNDVFGHAVGDRVLQRFADVVRRQSRHGVEGFRLGGEEFAIV
MSGMSALEVYETLRKIGASFGAEVVGTKLGPLRSTVSVGVCFGDDEARSLEQLLLGADAA
LYVAKRAGRNRVATAETADNGAYREPELLFA
>A0A380WTZ5|diguanylate cyclase|EC 2.7.7.65|Aminobacter aminovorans|TrEMBL
MRIVVLKTTAVTLISILGSLALVLTIVPALGGKVGAIAWLMCLLCPLFIATPLGFFTFMQ
ERTLKLAHEDLTRAHSQLAAAHRRLSEKASRDEMTGMLNRENFFAALDGSRRKSDRGALL
IIDADHFKQINDSFGHLTGDQALLQIAAAITRGVRSGDILGRIGGEEFGAFLVGATVDEA
KLVAERIRSEVEALRFQPSDERAVPLTVSIGGTDCEAEANVSELMRNADKRLYEAKRRGR
NRAIFDMGVSEAA
>A0A0M6Y3T7|diguanylate cyclase|EC 2.7.7.65|Roseibium aggregatum|TrEMBL
MGINLTRNVFSKSNGTWIASIVAAVCFLAGIAVTAHVGQLVRNELVSQHKRQAVASLSEA
RARLEGEINRTVAHGLGIRAYVSQFVEQPFDMEDYREIAVELIEENPSIRSIGLAPNNIL
RAVFPLEPNQAALGLNYRMNTAQWPAIQQAMVTREVVIAGPLELVQGGRALLIRIPIFPA
SFLGQPLKERSYWGVATLVLDEEGMMKTAGITDVINGIRIGLVNRSAVASNNMIFGSPSL
LEKDHVSLPLHLPGGLNWELVGLPEAGWSSTGNQVWITQLVGSLISLVFGAMAFLLISEV
YKVRSMALHDPLTGLANRRLLEDRMHQLAAMCERSGAGFEIFYVDLDAFKPVNDNYGHAV
GDQLLIEVGQRLQNQIRQTDTVARVGGDEFIVLTPGNMRRQEKDTFLNRLGERVTEAFEY
SGARIDVKASIGSASYPGDAATVEDLLRVADGRMYAQKAKSKRNSQDIPGNGLPQTG
>A0A1J5QIH5|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MTAIPAPTSDIAIDVRGLSKSFDGREVVHDLSMQVKRGTIYGFLGPNGRGKTTTIRMLCG
LLTPDSGEGRCLGYDIRRDANKIKRLVGYMTQRFSLYQDLSVRENLEFVARLYGLRDARG
AARDMIKRLGLGGRENQLAGELLGGWKQRLARGAALYVLVLSAEPGSDAVLQALDAGAND
VLAKPVEHKLMVAKVKLGERAVRLVAALESERRAADGAQRELSRCNEDLRVAAYTDELTG
LPNRRALDEFLRGSASDALGRGEPLCCVVVDLDHFKRINDAHGHETGDRVLCSVARVLQA
QTRATDMLARWGGEELVLVCPGAALDAAARLAERMRLTVERLQQVGLPPLTLSAGVAQAG
ADGVAAMLRAADAAMLQAKRGGRNRVVRAELSAPQT
>A0A1J5QNY6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MVFYVMKNHAENLLRHNLQSSLENHIVLARAELRQGFEKTTMVATRPFIIQQIRLTDSPD
YHDAAVAALQKGVQSFVSTGFSAIALLDRSGREIVRAGHFLRRPELEVPLHFPDQTQLAY
KGQFFLRASIPIVDAKHVIGSVLTETPLRTLSGMFIQRKGLRTTSDLALCAPSGKNMMQC
FPTTLMQRIFNLPRTSSKGTPFPMDYALDGKTGFIISQDYRHQQVVAAYSPLDDLGLGMV
LKIDSSELYAPIWIQLYYLLPLMVGLLGAALLSLRWLLAPLVNTLAHSEREARATNARLR
DSENRVRLLLDNVDEGIVSIAANGDIELFNPAAERIFKYDVAEVIGKNVSLLMPEPSGSE
HDRYLKNYLQTEEAHVIGTTREVQARRRDGQIFPMEIRISEFSLNGERKFIGIMHDITER
KAAEAEINHLAQYDALTDLPNRRLVQDRMQQTLARARRTQAQFAVMFIDLDRFKSINDEL
GHDTGDQLLQAVAQRLKTTLRGEDTVGRQGGDEFIVLLAWFNAIQDAALVARKILDALAE
PFLINGLVLHIGASIGIAAYPQDGDDVETLLKNSDTAMYAAKEAGRGTYRFFSQATPSPM
AGS
>A0A1J5Q0P6|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLKTLLLRWGLWPAVAGATLLSIVVSILVAGGLTYDVFGGSMGSSAWVITLVTPTIIAPV
MSFFTLRLVLQLEIARMELQHAVHHDPLTELHNRRFFMQALQNEIDHAQSGGPAFAVALL
DVDNFKSINDRHGHLGGDAVLRQIAQACRTHTRGSDVFARIGGEEFAMLIRHSGLEEARE
CAERLLHAIRHLEVALHDGLLAVSASIGLTVYQPETAHLNVLLRLADQALYAAKREGKDR
VAVRLAASAAPSAESPI
>A0A378UNC1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MHGIGLWWRQPDHYDWLTSYLKARRLLTFMRWLMFAVLSTIAAAIALALASPSGPQTPAQ
RIATCVASGVLAAIAVSYVCRWPTRYQSQVFSIAGNACIAVGVLAEADPRTAMVGAVAFV
GLAGYVAFFHTAPFLVLTLGTGVATAAVSAARIAMAGDSAMAVAKLLILCGGILAVPFCG
QVIVHWLSVDSLKSSTDTLTALPNRRGFFRSAQTLLRHADYRSRPYFTIAMIDLDGFKRL
NDTLGHPTGDRALVAVADSLRAVSGTNTAVARVGGEEFLFAQLSTPEQARENAEELRTAI
AAAPWGVTASLGMASTVIRAPALKPLELIEWLIARADAAMYEAKRSGGNQIRYAGDLTGD
GWQAH
>A0A378RC04|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MSDAGALGDEHRLRRLIDKLPAMVGYWDGDLRNVVANDAHRQFFGLTPAEIRGMHITDLL
VGDLGEASLPYVYAAMAGEDQIFEKTLTDHNGITRHVQASYLPDLVDGQVRGLYVQVADV
TARVEAERSRDDAQRLFEISMDNAPFGKAVFTTDGRALYINSALRELLGIQPHDAAALHY
YDGVHPDDFAVAEQDWRELLSGAADQIATEVRYVRSDGAIIWVHRAAVLAPGAHGGADVV
IAQLQDVTARKGIEVELAHRAVTDPLTGLQNRHSLVARIAEHRTAHPGDWVAVLFIDLDG
FKTVNDSHGHAAGDAVLEAAARRLAEAVVSPNAVYRLGGDEFVVVVVDDVSAPVVEQLAQ
DVGAAVSGTYPVEDGEVTLAASVGWASSRTADAAELIRDADVDMYRHKARHRQGDQRLSS
TEIVARDGE
>A0A1J5RS85|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLHLLIPKMAEHPAAFTPQNYAVWYEYSTGINPALSQVIAKLLDSGEKLDDYAIERLYLK
YVSECNMDVEWALREDIQQLLKRLAKSTEETDAQAHQFDNRLHDYGDTLKQDLDPPKLIA
LIKGMADDTSKMIDSMRALQSELTASKQNVEKLHEELQAARGESLIDPLTEILNRRGFEN
SAKLTLSNHEIISKGLCLLMVDIDLFKKINDTYGHLFGDKVIRAVANTLKDKVCGQDSVA
RLGGEEFALLLAETNVSGARIVAENIRQTIETCQIHRLDSHEKIGGITISIGVAAYETGN
NLVDLLGHADKALYVSKKEGRNMTTAYADLIPHAETLADVREQTI
>A0A1J5T1E7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MKHSKIDDFATDWQQLHQQVPETTKRLISDTVNRCAPDLATLFYEHMLADKEAKPYISHD
VVSQRLHASMQGWLRELFSLQQQDPKEIYKYQCHVGVVHARIQMPISLVLRGTRLLKQAI
TEYLVVTELDRAGLVQATRFVSEVMELSMSAMTDSYIVNVGKSVRTDESYRMFALGQNML
AERERQRAALSEWAQHILLHLLGDEAAGVPEMRHSEFGLWLQHKASIIFHEAPELERIRA
CVERLERTLLPSLIEKRRSGGDARAAMRQVEADIGEVKFLLTGLFDRFIEVESGRDSLTR
LLNRRYLPTILMRELALARNSDVPFAILLLDIDHFKNINDTHGHDGGDLVLQQAADLVTS
SVRVGDFIFRYGGEELLVVLVEIGREQALQVAETIRERFASEPLRVGDGKVTDVTVSIGV
AAYNGHPDYERIVKDADDALYRAKNYGRNRCELAD
>A0A1J5QJW4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MEAVDRYRQELELVLEAAGFDLWENDLVDGRVTRRADKVLGELGYGDDDVARCIDGIFSL
IHPDDAAGLRAALRRHVDGGAAQYRAEFRLRAKSGAWVWYANYGRIVDRSGAARRLLGVT
FNIDAGKRRELELARMNARLAEQNAQLEKLNATLRELATSDSLTGIANRRKLLAVGEREL
QRALRLGHPLSLLIVDIDDFKEVNDTWGHLNGDRLIRAVAALCAGSVRASVDTAGRIGGE
EFAIVLPEIGGGDAHALAERLRGAIKAQPVALDGGTVVCRTVSIGAATLADGCVSFIDLL
GCADAALYAAKSAGKDCVRVHAAAPRPRRHDDEGEPLAAD
>A0A1J5QFR7|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLRRIVPVWLRTDDLAVETGQLLLLATGAMALTTAPFLTRSGVTWHALAGVCGALLLVVG
ASLWVSWAALPHWASLVFPITTLAALAAIGLTTSGIADAYVGVIPLLFVYVGVFHGARPA
AWVLPLAWVAYIAMAGSLTANMAVRLLVYSTVWLATAALMAFMVDQQRAVTDRLEAAALT
DPLTTLGNRRGLDARLATVTPGDCVVICDLDHFKTVNDTRGHAAGDAVLGLFGATVTQHL
RRRDYAARFGGEEFALVLARTEPAQALAALSSLRAEWDAAGTGVTFSAGLAMVDGTRTTA
AVVAAADSALYRAKADGRDRFRVEIADEPAVLAAAPPAVPHLVAPMAGSPTLPTLPTLPT
IPADVRRRASYGGRTAVLATTGAPSHA
>A0A1J5RUX4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MFRFIAGVRRIPAASWLLCVLCIVPIASVASPLRLEGNWYQAPADWVYDGQHSPDNAGLT
PVDSVSRTGGRFVFEADLSIDQSGTQVLDFKNSSVIGVFHHWIFDREGRQVGSAEGGIEN
AADNPFLLRHGREFHLPPGHYRLITEVSAPFFLARPQPYIDSLSHYRQAIKPGNALVFLC
LGILLGLAIYYSALALVRRNVVDGMYALFILGNLLYNGTALLVYPDLFGMHWFYLISMPI
LFSNCAYAMFVITLLDIRRDGNPRLYRLGMWLLALLGIFILLALLKPHWSLELDRYGVGL
FLLFGLVAGIVRARQGETTARLYLVAIVTFCVLGFASIVLGGLPGIYTFYMEHMGLAAVT
VEALLLALVVAQQFAQMHRERESALTQARRNRKLAQTDALTGLPNRYALELDLAQLPVEG
SLTFIDLNGLKHYNDRFGHERGDELLCSFSRNLKNLLPECACLHRLGGDEFAITCKEGDI
SRTEARIGDAMKALHAEGFESAGVSFGSVRVAENPAKDRLMRMADDRMYESKRRGKVPQP
S
>A0A1J5TFI1|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MNSATGVERKSKLSLLNDFLFFHINERNFAVRIEQINSRIRLYPRIVISQLAIAFLLVGV
MWNGVVHDVLFAWLALACAAHTFELVYWLRFHQDAQNIRQCRRWNIGFRWFSGIVGIIWG
STGLLMFVPGQMVYQAFLICVVLGISGAAVTSNPVHPPSLFIHLGTLISPILFRVLWVGD
WTHLFLGSMLVIYILFVLNASLELIHTFEKSLQQRIDNEKLTAELKQAQSIAHIGSWHYA
FGTGQFTWTEELYRIFGVSSKTFIPSTETLISLIYPDDQSAMHKWIEACATGQKPSALEF
RCLCPDGTISHIQWHGELTLDAEAKPSYIVGTGQDVTERKRVEAQINNIAYHDALTGLPN
RRLLDDRLEQAFAACKRSGQYGALIFLDLDNFKPLNDTHGHKVGDLLLVEVAHRLGSCVR
KVDTVARFGGDEFVVILNELGDNESECAEQAGIVAEKIQYALAGTYWLPFESEGSTKLVV
HQNVGASMGVALFNKNINAENVLKWADVAMYQAKNTGKNRILFHEALV
>A0A6N3DYW7|diguanylate cyclase|EC 2.7.7.65|Clostridium paraputrificum|TrEMBL
MGEYKERYEKLKKEYETYQSFVELQIQKLSNRNMKLEKDMNALTNIVEISKYINSFLSDE
NLIAMINDMVLGLLGVSKSTILLEENGELVVKATNIKEKDICWSSDEYNYIRVGKSYLIN
SKDPIRVYSEYDLEIRSAMGMPIKIRDKFIGFIVVEHSVFNFLDLEHEKFLRSIANQIAV
AIENSMLYRELQQTAKMDPLLGVYNRKCFFQVVEKRNKENPGKEYAIVMVDLDNFKKFND
TYGHQFGDEILIRTTEVIKSMLEPDDIIARYGGEEIIIYINNVLSVMDVYNRIEAIRECV
ENNKVIKDNVARSVTASFGIGYYPNDGKDINEVIKVADKFLYRSKAMGKNMVLISDFLK
>A0A1E3KYA9|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MNKQSKWIHQFFKVYWIVIGVHFFSQWGSFVFLDYDDDAYHFYIYILIMPTLLMSLVTLI
TRWIYIRWNHLSFYVLFSASTLITWTIIYLNYDIRIITALCLLPILSAVVFFRRRLLWIP
SVLQLIAFTSLYLADSHFRNYLSSFDVIAVISFIIVSTFIAHIIVASGIEILADLQLTMS
AKQDLIVKNAIMSKLSKTDGLTNLYNQISFRDYYNTAFDYATKGAKLHLALIDIDDFKVI
NDTYGHQAGDTILGKVSQVIQQHMSSSDIAARYGGEEFALLLFDQTFEEAYALVESIRSS
VAELQHLEMNGKSVTVSIGLQSYGSEKTKEQLFEQVDTYLYEAKRTGKNKTVTAPHTEVS
>A0A3S4VUN4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas stutzeri|TrEMBL
MTRYLLLALLAFAGGAAATADVTLELDAAERDWLAGNRSVSICVDPDWLPFEMLNARGEH
EGIAADLLRLVAQRAGLQLDIVATSDWGQSVAFSQAGRCQLLSFLNQTPVRDAWLIFTQP
LFTDANVVIAREDHPYVADLSALEDVTVALPAGTFVEESVRRDFPRLRVISTDTDAQALA
LVNERKADLTVRSLTVAAYTIRREGWFNLKIAGQLTSLDNQFRIGVLKSEPVLRDILNKA
IATITPGELNQIANRHAPIRVESGTDYRLVVQIVVVFSVMMLTSLFWIGRLRRLNEQLQV
KSQTDPLTGLANRAALDRRFARALAQARRYSRPLSIVMLDIDHFKSINDEFGHQMGDRVL
KEFADLLVGCLRGSDAVGRWGGEEFLVLCPETTGRQALTFAERLCEQSRALSFSTGQTQT
LSAGVAELNATDTVDSLLRRADAALYRAKHEGRDRVCCHAPDEQAS
>A0A1C5KSS6|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MKKKRIEQNEIKRYFLIIAAFLSFMILSLLFFLSWLQQDVEVSSRKTVATNVERQSYHLK
SVLDIQFNYLTGMASYMGEGEDLFCQENKRLIQSIVKEQDLDLIGIMKADGDTYYNNGAR
KNVKNRGYFKKVMQGQKIMSPPIESKVDGRTKVILAVPIYRNGKVTGALGASYNVGALNQ
MLFNDIYDGIGFSMIIDTSGKIISCDSGLSYRKIGINDNVYDFYTKSGEVAEKTMKSAKA
NIKKQKSGILVLKEKNAMSYLAYEPLHINNWMLCYLVPQSKAQEEFQFIGNKEVILFAVI
GVGVITFFILIFQRTSMKQKKMREIASRDGLTQLYNKAGTEQRIKEWLHSDRSKAGAVLM
MMDVDYFKQINDTYGHAVGDRVLYKVGHLLKSSFRENDIVGRIGGDEFLMFMEGITSEEF
AVRRMENLQQYLRELPIEELEEHTLTCSMGAAFMPKDGTTFGELYKHADEALYTTKRNGR
DGFRIYHEVEEKEV
>A0A449BFN2|diguanylate cyclase|EC 2.7.7.65|Haploplasma axanthum|TrEMBL
MKNEYFLKAQERLKNEFGLNILDDLILDSKERVFLFSINVEDDIEFTVMLGNLEILGLEN
KNKIMLSELLNYFDFNNDYARVLGKKEAFKQLKDFFLENNKAHKIVFPILVNNKRYWINA
YQRPVSKNSKINYCVFSEISKSMSNEEIAWYNSHIDPLTGLYNKYTFDYHYNIRYTNENL
HVIYLDVDNLKKINDTYGHKIGDQVLIELASVLKKYETEYNHFYRIGGDEFLGLIFMDEI
RIKELLQKILDEIMKKIFSDEEIKVTISIGVVRALQRKNLVDKADKLLYKAKNQGKNGYV
YEIEGE
>A0A150HZT5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter venetianus|TrEMBL
MSRANLALKPQSFFQLFALFTGVILLCCLLGIATRHLTFLASFWPANSVFLGLLIRFPQT
RHPISFIGAAVGYLLADALQGTPFLLNICLNSANLVYVITTLILYIKFNSYIRSMHQGYF
YLTLFSFCCIGGLASSLFAASTLPYMNTQFSLGSFWIDFGYWFTAEIQNALLLLPAIISA
PRFSEFKQQLIEFKTQTVQESLPLFAVIFSIAVGYYDNGPGSLLYPIAALIWCALRYRHF
SVAIITSISCAFVIYHVSQNYLLLYPEQYLNNTISIRLGLIMMTIAPLTVSSINMVRSKL
IQELQHTIAHDELTSSLTRRQFLQSVQLLQHQASNASQTTAFLMLDIDHFKQVNDNYGHQ
AGDLALQSCVQNIQALLAPNDLLGRLGGEEFAIFIADTNPEVVYQCAELIRQQVSNTSIQ
LDKKQQFSIQLSIGICICTPENQHSIEQLFKQADDALYQAKRQGRNQVVFST
>A0A523HFI3|diguanylate cyclase|EC 2.7.7.65|Caldithrix sp|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A449BDX3|diguanylate cyclase|EC 2.7.7.65|Haploplasma axanthum|TrEMBL
MTLEGMLITVLIALINFSFIGILLFINLKNPNRYDGLRSWINSNFIRITGSILIATSEYI
KENTIKTIVSFLGYFLLVSSLILVNKSIYKLVDKKSNIIWERPVNIIFLVLLILFGIVIK
NDLFFTLVILIAQAFYTLWQIIIVNTNRTADDRNSWLSFTILQTMAIIVFICYVLFELLF
NEFNITNFTGNHKGQNIIIKSLVIMSTLNSIGLLTRISNVAPKYVDSENKLFRTVINLTS
NMIVVYDKETKVINYVNPHFTKKFKYRNFELLSKKRFDELFVTKDEYFKLKEEYYKGSNL
IEYKTKMLTRDNKIIKCLISISLIPFNDTESYLASIVDITNTISQTEKYEFLASYDELTN
LPNRRVLYEVFKKKKDAFKSFILIILDIDNFKEINDQYGHNIGDEVLKILGPKLDYINDD
NDLVARYGGDEFIFLIDLNNNQTFDEIINKLLEVFKEPVIVNNERIKIDISLGVAEYPID
DDGFEGLLEKADIALYRAKKYDGDKVVVYNEKDEIETLI
>A0A090NG01|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MAMIKKTMEIDVILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWI
DHLGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALT
DYKIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGH
LIGDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAI
SHSEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A1E7W8K5|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MDIKTLVLALALGNLSLCVALFFFEQSAGAPAGARRVNSLNGVGSPGTATWARARQLQAL
AWGLVYLRGTLPDFLTIPLANTLLLAGFAFDAAALWEQAGRRIWRRYLLPVLVLAVAAFV
GAWLLQRTPSERQLISSLAIGFFVAAGAGALGRGWTAGTLLRRYLVVSTVVLALAVVARG
LLVLLLPNGWSWVSPELVQGIGLVALYLVMLGNGFGYLLLVRQRLQGELERLEVIDPLTT
ALNRRGFHQALAPWLALARRPGQPTALVIVDLDDFKRVNDHYGHLAGDQVLVAMADACKR
QLRDSDTLGHLGGGEFAILLPRTAVEEALLVAERVRAALAAQPVKAEKAIINLTASLGAT
TMRADDTTVGLFQRADQALRQARAAGGNQVAAQVTGSAAVLDA
>A0A1E7X4M6|diguanylate cyclase|EC 2.7.7.65|Duganella phyllosphaerae|TrEMBL
MSAPVPLFGTAADLEPDLFAAEQQALDQARRAAAHDDNHQGALRDLVAHYERLLRESRRL
VQRSDRAERQMNQLNARLQEMATQLEYRASHDPLTGALNRGAVIEHARSCLLLHDIVLVV
LDIDFFKQVNDTYGHPAGDAVIQAVVVCLTEMVEGQAFIGRVGGEEFSVVWPGLTPVQGL
ALGERLRQAIADTEWPAPITAPVTASVGVSWSARGSTFEQAYIRADQALYRAKRSGRNCV
RMAD
>A0A090NA82|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae WRSd3|TrEMBL
MQHYFYYIHSKHITSCFIFVDDVLSCLQRLNNQHLPAVSWSCSVSDQIIARVSQSLAKEQ
SLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVSWDYSLC
KRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSE
RAEQVLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFS
LARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEF
LVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAA
DIAMYQEKKHKQKTPFVAHPALHS
>A0A6N3QDH3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAYRLGGDE
FAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASAEKLQEL
ADHNMYQAKHQRAEKLVR
>A0A7Y8CSG0|diguanylate cyclase|EC 2.7.7.65|Cedecea sp. P7760|TrEMBL
MIIKNRQTETAFHSLILLVGLGLLSFIFTLYSMELTLKGTDLVPIWFTTALIMAAFFRTP
IRQWPLIAAACALGSIAASSALFPFNWLNVTLTAINLVEALLGAVLLRRFLPRKNPLQNL
NNWAKLAICSAIVPPLAGGLLVTMLPVPVDASALKTFLIWMLSESIGALALMPAGLLFKP
YYLLRHRKASLLFETIATFAVTLALSYFSLIYLPWPFTFIIVILMWSAIRLPRLEAFIIF
LATLMMVSAMIAIGKFPMVTPHPRVLEYAPWLPFLLILLPANVITMVMYSSRKERKHITE
SETRFRNAMEYSAIGMALVSTEGNWLQVNKSLCKFLGYSGEELRNLTFQQITWPEDLNLD
LQHLSKLASGRINSYSMEKRYYTSAGNVVWAMLTVSVVRHTDGSPLYYIAQIEDINDLKH
TEWINKRLMERITLANEAGGIGIWEWDLTNDVISWDKRMFELYDVPPHTKPTYQLWLDSL
LKEDLAHSEAVIRESLKNRLPFKLEFRIHVKDGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNVSFMNPIAEKLSGWAQEAAIGQH
ILSILRITFGDNGPVMENIHSGDFSRSAIEQDVVLHCRNGGSYDIHYTITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENHLKRLLQGAIEHRQHHALVFI
DLDRFKAVNDSAGHAAGDALLRELAAMMLSMLRTGDFLARLGGDEFGLLLPDCSTENARY
ISERIIRSINDYHFMWDGRLHRIGASAGITHIDGDNAIASEVLSQADIACYASKNNGRGQ
VTVYEPHRHYMEQGRDTMPLDEQWQVIKDNPILMIAMAIAPPRIPESTCFYLLTLRFWGS
EGDVINEPAFRAGLADPSLHHALDRRVFSEFFDKFAGQVARKGFGVALPVSGAGLVSDTF
VNELLDQLSTSRMPPRLLHLTIQSSDLLAEPQRVYANLKRLRKAGCRMVLSHVGRDLELF
NTLSHHLFDYVMLDPDLILNVHCNLMDEMMVTIVHGHAQRMALQTIAGPADMPLVMDTLS
GIGLDLIYGETIVQPQPLELLLNNSYFGIN
>A0A6I2I5B4|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT691|TrEMBL
MPHVPLTDNPRWLNRLSRRTNPGRVVNICFFVVLLFSTLLTWREVAVLEDAYISSQRNTL
ENVAHELNNELQLNIDRLQYFRNGFQAGLETPLAFEVMRNAGEEFERDRKAHQWSIFLDK
RRTFPVNGVSDEFVDNTSILSRDNALLRNELTATLEVGYLLRLSTSLRRVTQQMLYLSRA
GFFLSTTPVENSNDIVEQYYALVTRPWFAAQSQKSNPSRGVRWLSWMADTPNGQSRRVAL
TLPVDYQDYWYGVLAIEFSLPQIKQLLLTATAGETEGEYRLYDSQMNLIASTVKPGDMPE
RLSEEDKAQLAQAFEHDTRGGLRSNTRYISWEKIRNFDGVLIRIHPLNEGMRGDFGTISI
ALGLLWVLFTSMLIFSWFLIREMVRNMSTLQESLQWQAWHDGLTRLYNRSSLFDLAAKAA
KKCEQHHQPLSVIQLDLDFFKNINDRYGHQAGDRVLAHVAGMIGAQIREDDIAGRVGGEE
FCVVLPGLNKAGACAVAERIRQRINGREMLIGKSITLRISASLGVSSSDEKGLYDFEYLQ
SIADKRLYLAKQNGRNQVCCEDGECQCD
>A0A8J7VY84|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MKRKMMIIMMLLALVPTFLIGIITNNYMLKSLEVFQENALSDTAGVITLTVSRFYNEQYM
AVQSAAAQEPYIKILESAATKDNTAVMQWEAQAKKLIADSCLLIGEASLIDLDGKIIMAY
DSREVGIMLNKTELYKTILSGAEYYKGPVIFGDGSQRIDLAVPVKNQQGKLVGILKQRIH
LDYMREYIQNAKIGKTGYVFVLSKNGTLIYNGKKDQGLSTIYSEFESMSDLDQLINDFSA
GQLKDTSGIIKYRSNGVQTIGAYEKAENTDWLVVTAMEQKEVYAEVEKVRDIIFDVCVLI
GFLGAIVGYLMSRVMIHPLTALNLHLKRIAAGDLTTRCNVEGKDEFKELFENVNHLADNL
QRSEKELRMSARIDSLARIPNRYAIYEVLDTLLYKHKNQAILMLDIDGLKQINDNLGHDM
GDRVLAEVGEVLRSLPQHICYPSRIGGDKFLVFVTDWDEKRYPEKIAERLIKDIKGIRFI
DDVRVHISVSIGVEYLSEDRMDKKKLIKRSDNAMYKAKDMGKNTYVVYSQFNKKET
>A0A1C5PS89|diguanylate cyclase|EC 2.7.7.65|uncultured Faecalibacterium sp|TrEMBL
MQGIDALGYEEVMTFLRSTPANLFFKDTECRYLFISDVKTFFPYGEGQEEDVLGKTDLEI
WSSEEQARFYYEQDQKVLATGEGTSFITEVPRKDGTAYYQIKKNPVVLEGKIIGIVGLIG
DITERVRLEKQAENWAVHDDLTGLYNRNYLKVKGAEQLKGAIMPITIIMGDCNYLKRVND
AYGHEYGDLLLKRVGRVIRENLPPESVALRMGGDEFLIACSHFSAEEAEQLIERLHGELA
RQSDDRLKLDVAFGYHTVTEGPFDYTAVYHAADRDMYRNKHKNR
>A0A4R5LYR8|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia silviterrae|TrEMBL
MLSLTVAPGRYVGRGATTQPGMVGDTMQHSAKRTAGRTRPDRFSSIVMKRPRLVVTLCFI
GAMTLVTIVGLRQLYNLARDDLQSRQRDLEVRAVGVDALIDSERRRLLFLRNYAEHVLAS
ERQQRIGIQNPAVQAVLGETSRPVWQTPGSLSGPAVFGTNAAALAGLDGFHRNEALLPGD
IALARTLSPLVEISQHADAVQSTVAFISPNGVFVIAPEHQDLSVPELLRRFNTMNYYRGQ
LPERNPRRDVLWTPVYSGLQKGEAISTLSAPVYLGNQFRGAVVMDITQSRLLSLQLSTGG
PIDDEDDPVEFGLLNTNGSIVYFRNGVVIDERPARFSASLLQTARTSVDTWMQRGSGYIE
RNGQYLLYRRIGQSHWMLMAPTNNAELTLATARRVLSSPLIAAWIVLGVLLVSTLRIVTN
IFGHYVEASERLETLARSDPLTGLPNRRRFQEAFAEALERATRASQQPVALAVLMLDIDF
FKRVNDCFGHAAGDHVLTVLAEILRASLRSVDLPARMGGEEFAALLPDADLATATAVAER
VRLAVEAHARDAAALASAAHPEAIAFTVSIGVAASPVDCPADYEALMHVADQRLYVAKEG
GRNRVVGVDEQVPDARA
>A0A857JHT5|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MLRFWFKEFPQYPCDHTDYWRTRLISYALLVTTSYFLLLTIINIVTFSNFSLALLDGTGL
LFSLGIFAWFRATGNVTVASWAVTIMVTALILLFVTSAKGYSHSLYWATLVPPFAFFLLG
RKFGTAVSTFTFFICVLVVYKQMETQQPGYFAFGSLLNVIEVSVAHILLFRFYEQARSSA
YNTLAIRNTEILQLAETDKLTGLFNREKLESTLITLLSKVDEQHPLSVMLLDVDHFKKIN
DQYGHFEGDKVLRVLAKKLQELMREEDVVARWGGEEFVVLCATTSLEKAMQLAQRIREDI
AKQVISGHALTISVGVAQYVPSDSLDSLLGRADVGLYQAKNNGRNSVIAA
>A0A5W2JRE9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMALYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A2N4Z4R5|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENNAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVDALITEWRTAEQDAGYKNTQSLLQKIHIHCQHISSQLGVLFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRAIKHV
ADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDTQIPI
TASIGFTAHTGHPDYNLLLRDADNALYAAKREGRNCVKMHKGGG
>A0A5X7K3R1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Strasbourg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRENRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V5X497|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bareilly|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A501SEP9|diguanylate cyclase|EC 2.7.7.65|Pantoea vagans|TrEMBL
MTIEILSPQKSTPNCWLSALFLGCIVFVLTLFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAAANAIIIGPAFSNIKFALLNLIQASVGGMLLRALLDRRAPLNS
LHDWARMVLSVGIVTPVLGGLLALWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRAQFSELGRQLPETLMTLLLTLGASYLSLRFLPWPFTFIVVILFWCAVRLPKLQAF
VLFFINASFISMLLALDAVSVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKLH
ITDSETRFRHAMEYSAIGMALVAPQGKWLQVNRSLCDILGYPAEELKRLTFQQITHPDDL
SLDLQHASRLLEGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDGSQEPLYFIAQIIDISE
LKQSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLASHESPSYDLWI
HLLHTADREYAALTVQQAIELRSAFHMEYRVVNAEGQRWVRTQANRLLSKEGRIERMLGI
CQDITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGLSQEQAA
GQPLSELLHITQGRNGPKVENLLLCQLPPEKITPSLAEDLVLHTPDGGHIDIHYSITPLR
SEAGVEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQH
QHVLVFIDLDKFKAVNDTAGHAAGDALLRELSDLMQHHLRSSDFLARLGGDEFALLMPDC
DVGQAHDVVQRIVAAVNDYRFQWLGRLYHVGASAGVTQISAENCQSSDVLSQADIACYNA
KRSGRGRLMIYEQHSLPLPGNHQGMDAAMIDALQIELPAWSVAPPKTPQAAFIWLLDVQL
LTADGLLLDETLLRNNLHDETLRRRLDNNILAVFFRHDMEKLNQKGIPVILPLDAGILSD
AAFVEQLCQRFVAAGLSESHCGFAFPAASVLSKGDQLYSALLQLRQCGCRIVLQHFGRNL
DAFTLLSNEVVDYLVLAPELVANVHNNLMDEMLLTIIQGQATQRNIAVLAGPVSVPAVLS
TLATLDVDGVWGSAVAERQPLRALAEDRIFAIR
>A0A448C057|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MTTSLFFLMWGLATALALPLLLPFQARGVRGIRAFIAANALAVLSLLAFATARLIPPGVY
VIVSNAAWVFAISLVYVGVRQFFGLRPHIVRTAGISVLCVLGFAVLLYGTDDLAGRMLLF
SGFTCVSALMTGRVIFQQRDQIRTRGVVLYLMLAIVGVAALHALRVLVYGLGWAEPVSLV
QPSPWGLFFIVCGSVAVPALFLALLLLVQTRLSEQMQAALTFDSLTHVHSRRSILDELER
ELQRCARSGSTLAVLVLDIDHFKSINDRYGHAAGDTALRHFAKVAQNAVRATDRVGRLGG
EEFVLLMVDCDPARALVHAQRVCDALRDTPLYLQGVEVPMTASGGLASYQSGDSADVILA
RADVALYRAKEQGRDRVEMAFGGRAPGRMQVSSLVGMAPAANGPLVTQEGAGR
>A0A0U3BT56|diguanylate cyclase|EC 2.7.7.65|Pantoea vagans|TrEMBL
MPNSPLSPRAGNPFLPVHLCFLAVFLFSSFLTVHEALELKNNYEERQRAQLSDFQKNLDS
QFQESLDELMYYQKMLTYALTHPLDSDHGREASQRFQQLRQQHTWQLRIASPRSMPLNGM
SDSWIEQDPLLRRDSEHIAQELRAALEFSFIMQFGDPEQEFHSRFWYTSRAGFFISSRPP
QSPQELEETYATMVKRPYFRELDPRNPQHSRLRWTEAYQGLFNEGLMITVSAPVVSGDYW
YGVLSMDFTQQRIHALLNEARQSYLQGKLLIVDRSMHEITRLSALHDKPLTDEQQARLEQ
QMRLHPAGIMRLGTQFTSWSKLTNVDAYLVNIQSLKQGIAQPLGRVALFLFGTWLLFVVL
LLVSHQVIFRLVRRMDDLSSKLTWRANYDGMTRLLNRNAFFEQFVALAAHNKQQQTPMAV
IQLDVDHFKNVNDTWGHAAGDQALIRVAGVISHTLRKYDIAGRIGGEEFCIVLPETTLAD
ASAVAERIRTRLAAKTILVNCNSTFSITLSAGVTGSEEQGDYDAESLQATADRRLYQAKT
SGRNRVCAEG
>A0A448C6T5|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MKPGAAELDRRIAELLADPTHAGHPLREALEALWRHTADQMARIERVTQLSDAYQSMAHE
RELGLCDQFDRQLRRLTRIARISDHYQNMMRDLNTALAETSSRDPLTGLLNRRALMDMIK
KEVERAARSGESFVVAMLDVDHFKAVNDRYGHETGDRALVELAGVLGESLREYDMCGRWG
GEEFLVMLPNTQPEAAQGVMDRLVGAVRGLAVAAGENDVLRLTVSIGMAHHQLGETFSET
LSRADQALYLAKQDGRDRVALGFPKR
>A0A0A6ZSV0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDVITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGRNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGAIPCVPCMLT
LAIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLT
FVTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQV
ALRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLS
VFARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLY
LTVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTALCVTVRKLSDIFIHSE
RFKCNVFYHFMFEEKSYFLN
>A0A378IE01|diguanylate cyclase|EC 2.7.7.65|Legionella birminghamensis|TrEMBL
MIVPGKPDNEPDRLKSLYDSHLMHTPIEQGFERITRLTKKIFDVPIVAISLLDKEDQWFK
SIIGLDANTTPRDISFCGHTILKDEVLVVDDAQLDPRFADNPLVVEPPSIRFYAGCPIHT
VNEHRIGALCIIDTRPRQISAHDKMILKDIASLVDTEIRNHQHIHPPEKKLHELNAEKRR
ELLDPLTRLWNRTGITQVVEYQRKLSKFNKSDFGIIHLSIDSFQAFVTEYGAEAGNDLLK
AITQSLINSCGCEDSLGYWGGKEFVIVLPCEEQPDILAVANRIRKNIAEESHLTRIGRVR
TTATLGVVFFDPKTHHNTVNMLTEAAQALQEGKLQGGNKIIIK
>A0A0K2G9L9|diguanylate cyclase|EC 2.7.7.65|Nitrospira moscoviensis|TrEMBL
MSILIVDDSPDDRLLLHSILSAAGYEDILTADSAAAAFSSLGLDGGKQAAARVDLILMDI
LMPDMNGIEACRQIKAVDRFRDTPIIMVTVKTDPVDLQLAFAAGAMDYVAKPVNKIELLT
RVRSVLRLVHEIDRRRAREQELLEVMRQLQEANQMLLRLSCLDGLTGITNRRQFDDFLDQ
EWRRAVRDSTPLSLIMFDIDRFKNYNDTKGHTAGDECLKQVSAAISSAVNRPGDLVARYG
GDEFVIVLPGTGIDGAAQVAEGLRRRVESLGIRHAEGDLVTISVGYASVIPTRQASPTDL
IKAADQALYQAKQEGRNRAKPAAMLTLVENLRED
>A0A5P9D373|diguanylate cyclase|EC 2.7.7.65|Labrenzia sp. THAF82|TrEMBL
MAFILVDGAKQDQGVSEPANRYSDRTWKVPRQQISRLAFLLAGLLIAVTAASLVFVGLVA
SHASNRQAIDNEQQLFDGALAYQLRTIVREQISVASSDEAVARLVNSLDPVHIQHSFDTL
WTDYRHNKVVLISGGGEVLAESFDDYIHIIRRPVAETPALQTVHEKLKLLYQRNRVRVPG
GFGHRSLQGVDPSEYALMGFTRIDGKPAIFGAMPIVPDKHAQTLPDGPPTILFSARYLDS
LLLKQLNAQLRFESFSFVEGSDPGAREPFHLVSDPNGEPVGTFKWASQTEGTSIWPTVIP
VIAVLSVALAALAFGIAWRIGQLTSSLQASEQQNRFLALHDTLTGLGNRLQFNRSLEASV
EALPDQPFAVVHCDLDKFKAVNDTFGHAAGDKVIRTIAERLQDIIAERGLACRIGGDEFM
LLYKGTLTRAELTRCAKAMIRAGNEPISLDATTSAQIGMSVGIAIAPEDGATFEQLVARS
DAALYHSKKLGRGRYSFFEETFLKEEETSQATGQERARRQVRRSGTGPAA
>A0A822V5Z4|diguanylate cyclase|EC 2.7.7.65|Agrobacterium tumefaciens str. B6|TrEMBL
MPPRTLSAFIRIYLKKNARMSETIDTNIFNLAPVAMWIEDFSDVKSQFDIWRSQGVEDIR
TFLLEDLSRVAACSQKIRVIKVNVRTLELFEARDQAHLVDNLHRIFRDDMLESHVNELSE
LWAGKTEFTSNAVNYSIGGKRLDIQLRGAVIPGHEETLGRLLLTTEDVTEREEARRKERL
NRRYAEGMFKHSPVSLWVEDFSRVRRLIEEVRERGIIDFRVFMDVHPEFVRQCMSEIRVI
DVNRATLDLFCAPDRQVLLQRLGDIFRGEMEKPFREQLMELWNGNLNHHREVVNYALDGS
ERHVLLHFSVFPGHEHDWSLVQVALTDITARKKAEAYLEYLGKHDVLTKLHNRAFYSDEL
NRLERSALRPVSAIVIDLNGLKDANDKLGHDAGDALLRRMGEVLNGVVTAPNHAARIGGD
EFAILLPGADKQVAAAMVETVYELLKINNQFYSSAPLSLSLGVATSEAGETMESLVRRAD
MNMYEQKNAYYAALRNRSADNSDTTKNGPPEATSLKRLF
>A0A8B3WF00|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MTHSVFITLLLFISFYSHGQVSTQDHHQDSPFNSSNLDSNTTPNADWNTLYLSTLTHSPS
RALNMLQTRYIGSTVYGDKLYLSSLLYQYMSHRDQPFYGIASNDSEYQAIEQTFISALMK
DSQGQYEEAQQSFLTLLAKMQSRSDLTGRALLKYQLCRSLNEQAKYHQANYYCSALQSDL
HDIADPVLPKFGTYRVIANNHHFRSDYQAALSTYLALINVFPPGHDISGIYNDVGNLLKE
LKQYEKSAEYLKEALTLRESASDLMKAQVHHSLADLYLNQEQSDLAINHFQTARTLLSSS
SHSYGIALTSLGLGKAYTQIRDYDLARGYLVNSLSDSNELSNDVIRINAYLAISDMFEEQ
KLTTEALNYAQQALEVSEQVTRHKYIAQSLLQLSDIHQSLGDYQQAFYFYQRYSSIQMEA
RDIDNRLALEALGLTHAKYEQELESSFLTHQAKLDRVQIEKMEHQRWMYNIVVILLLCAA
SFTVLINKTIRAKASIDAMTKAYGRTEIIRRIKRVRRCKGTDKQHVLVLLDLDKFKTIND
EHGHPTGDRALIHISQQIRKHLMNDELFGRLGGEEFLIMLTNTKPVDVRERVEELHYAIS
STVFLTESKKPLNVTASFAYLATSNALSDFDDLYSVLDQALYQAKSNGRNCIIDAYNEPI
D
>A0A7Z9BVI0|diguanylate cyclase|EC 2.7.7.65|Planktothrix serta PCC 8927|TrEMBL
MNPNEINHSWKLDTGSQQSYFCRKKTKINQFYRGERKYFSQKTSLALIGLFLQGLISLGF
HYHLYSSEPKEMIQSLMNWVLFLILIGWITYQVNRMDYRRSQTEESNPLELEQNYQEGRD
QNSQPQEWLYQAILSAPNPIMLHAEDGEVVQINECWAEITGYTVAELPTLSAWMERFTSP
EPLPSVKNPVGYSRLPHIFQEYVITNSHGHLRVWEWSSLRLGKLGDGRNLLLSTVVDITE
NRPTETPVQQSNEQLQLSLLQWTAELTQANDGLQEELQRRQQTTSELHQVSERLKQLLRS
SPAVIFSCQPQPNYKITFISDNVKTLLGYDVATFLREEDIWHNYVPDEDQDQWRDAFIQL
LATGTHIHEARFLHAQGNWCWLQLEMRLVKDGGGNPAEIVGYFVDITDRKQAEMQLLTTQ
NRLKTVIETVGSGITLSDKQGNFYIFNSKITEITGYTLEEAQSHVNFLGLLYPNPEAYKK
AQDQLKFVALMGSIFNIETTIQTKNGQSKTLLLSTVMMQDQQNPLFLSTFQDITPLKRAE
KALCQLIVQEHLVWEITHQIRQSLNLDDILNTTVTEVQQLLECDQVLIYRIFPNRQGKII
AETNLDESLKHRRSQAPLIPLECYKNFSRGRMRVINNINHDPINSGLLKVLKHWGIYSAI
MVPLFEQNQLWGLLIIYQDQGLRHWLQWEATLLRQISEQVGIALQQSQLYQQTQYQARRA
QTLNHVIQVIRQSLDLDTIFSTAVAEIVTLLRVDRACILQHFPQKQQWQEVASYSYSPYA
TPPILPSIQPLNRLETDDFNVPNSQEIQHLTGISGSWLPIPLRVGSQVWGCLGLLKHQHL
RGWKESEIELTCAIADQLAIAIQQSELYQELQVANQQLKRLATVDGLTQVANRRRFDEYL
AQEWQRLQREHADLALILCDIDYFKQYNDYYGHPAGDTCLKQVAQTLEDLLQRPADLVAR
YGGEEFAIILPNTNREGAIYIAQQIQGAILQLQLPHADSIVSQWLTLSLGVTYTIPSTLT
SVSDLIAAADQALYQAKQQGRARYCVQEI
>A0A7U9P1H1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli HVH 36|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>F5P0F1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-227|TrEMBL
MATAIDTHLVSNDFSALRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLF
RELSVPLIKHPGMSLRLVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAG
QELLETRATRILNGERGSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYA
AQDVKTGLNNRLFFDNQLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFT
LTNLLSTFMMRYPGALLARYHRSDFAALLPHRTLKEAESIASQLIKAVDTLPNNKMLDRD
DMIHIGICAWRSGQDTEQVMEHAESATRNVGLQGGNSWAIYDDSLPEKGRGNVRWRTLIE
QMLSRGGPRLYQKPAVTREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQ
ISRLIPLLRYWPEENLAIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQ
HISRLQPVIRLVNALGVRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQL
LVQSLVEACSGTSTHVYATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRY
SV
>A0A7U7J317|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MKTPNMIRLLEMSIHAFALAVVWRGASAMMTGGVSTESLGIIQSIEPFAIPVAILAIIGS
VAASQLGLRRWRKASGGSHRESVELVHETPRLDQQHEKIIKDLRKKLTELDQENSRLNLV
LQEKNACLLQDTLTGIGNRLAYEERLQQEFRRWNRFGNPLTMLIWDIDHFKQINDQYGHA
MGDVVLRGIAKLLARRIRSTDFVARFGGEEFVMLLPGADAEAALQLADQIRLDIAESRFE
NTDINLPVTISCGLTRFQAGDSPQSAFARADRALYQSKQAGRNCCTTC
>A0A2G4ASS9|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MLQFVEYSESAELAMSSINFESTYGVITIQDMNVVSVDANYARIYGYQSPEELLTNIDSF
LDLISEEYHVLAYQNYLETISGQRDPQVHTYVNVDRNGREFTVFSIDHVTEWQGRPALQV
TVIDLSPAIQLQNAVREQDKMYHDMIMQSGQGILVHREFKPLMVNQSWVKMQGGSSIEEV
LKLDSILTLVPKQNTDGISKHYQAIVSGELSGTSTVVENIGFDGIHRFFNIYDNAITWQG
QPAVQVVLEDVTQKVMLEKQLVHQANYDEMTDLLNRRAIYEWLREHIASDTHVVSMLLDI
DDFKSINDTYGHMVGDEVICALANITKRNVERVGGVAGRWGGEEFILFIPNASPNVSREV
SDQIRQQFNQVEFKVGEQIRFNVSVSIGVSDSRSCEGKVSIDALVNLTDQSLYRAKANGK
NCVCGEVFVSDISQALPH
>A0A7U7GGJ8|diguanylate cyclase|EC 2.7.7.65|Candidatus Contendobacter odensis Run_B_J11|TrEMBL
MGTWLQQGRDWIYRRLERRIAAYSVAAILSISLIFGGLSFTATLWIIHQYQRVELENRLD
RIVARLDNKVDIFVRHTQDLSKNSIVATALLDSKGRNIYLLPFFAYYHFPLAEPHSLALC
DFEGTLLAQQKLHPVGCLTHLPQHQAVIDAEQPQAVIVAIEQKPHLVLFQPVFYPGTGHT
EGYILATLDLQALVTEKDLAGPNAILMLRSPDGTLDFATGAYPESPDKPPAHPLFAAGPF
AAAGLTLVLHEHSTRLTGLETLLLGYGLGTLALALLALALSQRLAHRLAEPLLILNHTAR
QIAAEGSTAGLARVNRTDEVGELAISFNAMVASLRQAQENLEAQVQARTEELQKALIKIA
QSDEFKRAILDSIDANIAVLDGDGVIVAVNEAWRRLALTNETEPGKPAQRTGVGTNYLAV
CQQAASGEQLEEALAARDGIEAVLAGRQPIFTLEYPCHAPHEQRWFIMRTTPLDTEEGGA
VIAHTAITERKQAEEKLRIYSEYQRAVLDNFPFMVWLKDQESRFLAVNVFYAHACGFDSS
DALIGLNDRDAWPADLAEVYQADDREVLDSNRTKHAEELIKHTDQPYRWFETYKAPVRLE
GRIIGTVGFARDITDRKQAEFAMRESESRFRTLVDLLPYGVLESDLTGRVIFANPALEHL
YGCGEGKSVVGRFIWEFLANETKQGSLCNYAQFLVRDQPPSTTYYTKQRRIDGNVFDVQV
DWTYRRDEQGQVRGFIAILTDITDRNRMQEALREQAIRDPLTGLFNRRYLDETLPRELSR
CQRSGEPLAVAMLDLDHFKRFNDGYGHDAGDQVLQQVGLALHQSLRTSDMACRYGGEELT
VVMPGSSLADARTRLDTVRQAIMQLHLRYRDGELPTITVSIGVAAAESEATDAMALLIRA
DAALYQAKERGRNRVVVEGE
>A0A174IYL7|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEEKYRAEIEKKRAESVNRAWKIISVFVVVFQLLMLILMAAKPGGPFKTQRRTIYCILYL
TLFLVTGIAMILNRNFWRREKKNYHLYLHAELVYAAFICFWGCCVTLNDQLGGNDLSVFT
YMMLSVAALGFLEPVKAGVIFMAAFVFLNICLPGIQTIENNIFSNIINSFSIAGISTAIS
YSLYRNKVIVTKQEVTIRKQYEEITRVNEILSHQAMVDELTDMNNRRYMEWFIGEKIKKL
EEESGTISCMMLDIDYFKKFNDRYGHIAGDVCLKKIAEIIRGCCQDNDVAAIRFGGEEFF
ICLFRWDRDEAVEMAETIRKRIAECRFKINGEEEGAVTISIGVYTWHGEGKVQMDDLVCL
SDKALYQAKKNGRNRVEVLP
>A0A7S9NYN9|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MMKDNSQIEQSIYRLFEITPIPVVLSYPSGKLEYVNPAFNKMLGYEKEQIYAEGIVITHH
DDISVNQEVRRQLIDNPYSPVTIEKRYLHKMGHAIYAQLNIVAQPDTEGNVVRYISQLVD
LTTIRKSEAAEVLLNHLVNQSNDAIYVVDPKCGDFLNSNHLGYSRLGYSKTELLTLSVPH
IHPALQQAGKWQQHVDDIKDNGSQVIESTHNRKDGTAIPIEANISFIEYNGADYLIAIVR
DISRRKQKEKEVLEKANLDPLTNLPNRRIMEQKLSQMFSKVEQRNQFIAFIYIDLDKFKA
INDTYGHTTGDGILKGTANRLKACIRESDIITRLGGDEFLVVVNGFKNEEQIKLMAGKLL
AKFDSPFHIEHITLHVEASLGVAVYFGNNTDVHTLIQLADEAMYQAKQVSGTSIYYL
>A0A174VH95|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MNKKVRSDSIAFKLALTFVASVVIQSLLMTALLSLGGVIGQSRENAYQIFSEKVKKRSVT
IEGEMKNVWTNFELYTDELSRYFTEAERDENGELLEKEELLKAVAPTVLNALYYTKTTGA
FLILDRGTEETESYPALYFRNANPNRVDERNSNTYLLAGPWDVAQETQVVTDAAWKYRLE
LTDASRAFYEKPFSSVGLAGDEKLLGYWCPPFRLYEGGEEVVTYSIPLVDQRGRAVGVFG
VEISLNYLYKYLPPSDLLAVDSYGYVIGIRSGENDGIRPLVTHGALQKRILQAESPMELK
AKDSENGIFLLGNHNGNGAVYACLEQMGMYYNNTPFSGEEWYLIGLMEEDALLQYPHRIQ
EILFYSFLVSLCAGAGIAVLISRWFTRYSRLLELSEVPVGVFEMGAKGNRVYMTNQIPRL
LGLSKDQERTFCRSRNEFQAFLKKICEKPTEDENIFCLEQPEGKRWIRLTLREDGEKKSG
VVEDVTEEVLKTQSLRAENDLDGLTRVLNRKAFEHRQQKWEGMLELGKPLTVLMFDLNCL
KGVNDEFGHETGDKYIRFSARAISGALKDAWIYRIGGDEFAAVIEGVSENSPEECSRLLA
GQVEAYGKENGFQAGIAWGYAGSDPGSKENFSELLSRADHNMYEMKKQMKSADSL
>A0A549ZXN9|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MKDSMANTSQLSLLKQKLHSARVALDSMNEDKNDKLQTLLHFIGHLSLACKGQNLELDNK
LAKLRHNFSNFDSFEETLPELVDVEQLLKQQYNHVMVQLEDSRASLSRVIRQIQRVESVP
DKVKKEVNYFKKDLSKPFHTFWDYIPKVEKLVGFYESILEEQLAQGDKLVVLPKHRQLAH
ELAQMISEIEFRKDQRDRILIIKEELSNDIEIDSLIDAYQTVLSLLLDNIAREKSASQEF
LFALNDALSAVREVVSDSYNNTQRSFQLKKQLNREINTRVDNVGEAIIDINDIHSLKSKV
TEQLVSIRAALGRKEALEEREQALLRKSMETMRKELNDLSKEADTYKERLFEQQKLNLLD
TLTQLPNRAALEERMEQEYRNFQRHKQPLWVAVADIDHFKNINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLIVPDVNSTDIEHLLNRVREKVKSIPFKFKNQRITVTVS
IGAAQIINNELINETFDRADAALYRAKHESRDRVIIDV
>A0A202FFW6|diguanylate cyclase|EC 2.7.7.65|Companilactobacillus bobalius|TrEMBL
MTWSVWHVSPFVTSVFFILGVFTLYQVLYDGLKTLLHSKNIKIDDDSLNSIFGVLYMLIF
IFSMQATLVGTPISWQFMNFQLIGLIFCAYFLNIKVSTYFFFPIMVLYMFFNGSIGYWES
WLHGFILMIFYISLNKLRRRQKYRHPFVCYMLMGTVFGGLLWLCMKIKFALPIATFLEEW
SYLVIFEALLYSYVGMILRDSQLKLKLLQFANHDALTKTENYAAYTEEINNLFDSSARNK
LDLSMMMFDIDHFKQVNDTYGHLAGDKVLQHVADVVHTVINANDPNVKLYRTGGEEFNVI
FPGYDLDSTEPIVKEIFAALNHLDVNIDGEDISITISVGVSMISKKDTKPNDFYTRVDSN
LYRSKRNGRMRITVA
>A0A379HBG4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas nigrifaciens|TrEMBL
MLHLPTITSLSFIFNLLIGILFTSFYLHKKTTSFLLFGGACISFATAILLVSFKEELNLP
CLTHYLANLFIILSPLLLVIGLNKFNNKAVINLTPLAYLYGLCALLLVFVYNHVLSQILT
SFIVAILFLYGAFILLKTHCVAKLQQRLLIIGLVTHSLVMLGQVILLLLPFITSNNDDFK
PQLHILLIAHLFITTLCALILPFIIFANSESKLINLANNDSLTQLLNRRGFFSTCKNIKA
NTADKNHTLALIMLDIDFFKRVNDKYGHDVGDQALKWIAQHISQLFMNIGITARIGGEEF
AVLLNGYTLEQANTLAEQLSFNIRQQPFYCNDQSIPLSVSAGVSSTTINQLNLKELLLHA
DKHLYLAKETGRDKVVSQYDHTSSRKPTRPQYNT
>A0A165MPF1|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MVDADGWYREMFEASTVGMALADEHGLLLLANEAYAAIVGCPRDLLWGRSSREFTHPDDL
DQHAAMEQMMDDAEARGESVHVEKRYLHPDGTVRWGWVSASEVPGPDGRRWTMAVVHDVT
DRRRLEDDLREAALTDPLTGLLNRRGWRDRLSQLTTPRGVDVSLAMAMIDFDRFKSFNDK
YGHGRGDRLLVQFSTAAMQLLAGRAYVARWGGEEFAIAMPDTRSTTMATVLTELAAVVPD
EQTFSAGYTTLRPGESLYDCFDRADLLLYRAKRDGGARSLGDRSSTPSQ
>A0A649YXW5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MGIHLDITTLSIICVLLSLCYCIGLLLIQQLQPSVSGISTIASALLLLSVSFFLLSFGNQ
ITHWVSKILANSLMAFSYIILLLGVCQFRRFPRIIANIGFYSFPILIVGLTYFTFFMPST
NARVILMTVYVSSLCFIAILANQKGKSTDITPSKFLLSLGLATQGGYNLFRFIWTLFEER
IDDFMISGMAHQLAFVSTLLMVIFIGFSVTWMLTGRLVATIYDTSIKDELTQLYNRRALE
ELLPKEIARSSRHKQPLSVLLLDIDHFKKVNDTYGHQAGDRVLRTTGKLLILQTRKDDLS
FRYGGEEFLVLLPNTDVEKAVIVAEKLREAIKRARMLPTNVDSCTASFGVTQFNGEDDWQ
TAIERADQALYSAKENGRNQVTART
>A0A517ZGD4|diguanylate cyclase|EC 2.7.7.65|Maioricimonas rarisocia|TrEMBL
MMREPGRASQLGNWAMHLTTSGVIAWMGLALILVSHHPKCVEDLGWLWYYTGIFGLTAGV
GLSEAQRRRELGQRALLEECVRDALTDPLTGLGNRRVLHTELERAVTGPSEAYWLLLIDI
DNFKDVNDTHGHQAGDQVLRTVSDTLRNCVRSSDVLTRFGGEEFAILARHSSFASVLRHA
GQIRHRIAATRCRHCNVVLRVTCSIGFSRAEASLPATALVEQADQALYLAKGAGRNRCAW
HDGTGTALVHATARIPDLVAQTCPSITDRPQVSIGDRIDGTARDPFESLQRVECSSTAGV
S
>A0A8E7VPA6|diguanylate cyclase|EC 2.7.7.65|Salmonella rubislaw|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A7S6Z0E3|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MGFEHRQWRSSHRRAPFAMVLLFALLSLADLAGAQSASIRRYAHDQGLLGLAGTCLLQTR
ATLLWVCTESGLYRYNGRIFQQVPLDGLRNEPTTSIAETADGRLWVAGFQALFVGDEHGF
RKLRPDEAEHLGEQMQLASLPWGTVLANGGTLEILQGRANDRWHSEPLLDTATRVRVPEL
SKSLSLSVDGDTLWVGCARKLCAIDAQRKVQVFGPEHGVPDDRWYSVLRDHDGGLWVRGA
GTVLYRARGTTAFSVRSLPLLDGSTVGRPASLVMDREGRVLVRRNDGLARWENGHWRTFG
ADNGLPPGSSDAILVDRDGDIWMTVDGEGLVRWAGYEWIENWDASQGMPAAPTWSIARDA
QGALLVGNEHGIGRQAEPDERFVPALHSAGIQVVGMQRSQDGSLWTLNSAGILRRTWPDG
HSAQIAKLPRTARRLLIDRQGRLWMLSVGGLFVIERPLDGGSLQEVADVPAIAYTDIQQT
ADGTLWISSSNGLFRLRDGQWSKVKVKVKVNGGTPEPWIAKFHISDSGEVWLAFYRPGLW
HGMLLHDGLDLQEISDEALRDVGVYLLRGDSVGRVWVGHARGVEVYDGERWAHLSQSQGL
IWDDVSEAAFAEDPDGSVWIGTARGVSHVSDPARLFDERQPSVRIDSVSRGGMPVQRGQL
LGWSDKPLHIELSTMEVYDDPTRLTVRYRLLGLHDQWIQSDNLSIDQPPLPSGHFRLQVQ
VLDRYRRTASPIVDLPFAVAPLWWRSPPAIALYVLIGGGLLIGLWRWRHRHLVARERMLA
ELVSERTYQLEREKRELENARAALALKASHDALTGLLNRSGILEAMAEELQGCAHGEHPL
AVVLIDLDHFKQVNDEHGHLVGDAVLAKVGARLTACLRDSDKVGRYGGEELLLLLPGMSQ
QSQHRLRAIHEALSLAPYEVGAARPLQVTCSVGVSWFRVGDTAASLLARADEALYRAKRS
GRNRIEPEEPESSVA
>A0A5P9HFL7|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF12|TrEMBL
MKHRLGALPLSAVAPLVALAGLLPAASPGTGANLILIGLTAAGQLAWHLRRLRLVRLAAW
PALAWLALGLCSYLLPEDWVSQAGWNRWAEHLVAGSHVDDWRPPLLTLMCLSLLNLSLLT
RTRANLGAPLLMGTAGLALLAQLLMPHPSPGPLALSAGGAMLAAQACLLLAQLVDSLGGW
RTSRHSILRALWPSLLLAALTLTLWYQQHQATERRQQQEIADLGQRLAHRLSAEIDDHLA
AMRRFAASWHWMNGPPSADQWAYQAELYHRDFPYLLNIAFIDPQSRILRVHPPPDNTALL
GTRLFEAQPEGREVLERALHGGVIGQTGVIELLQGQPGMIHYLPVTRARDGRIRGAVGVV
IGLRDLADTLFRQVTPDTAALTLLDGERLLAYQGPARRTGPWHHAAPLMLDELSLTLVTR
PGLDTLLARRSRLPVVTLAVGLTLAYLLYLALFARRHLQRQHHETRRSNRELRREVRNRA
RLQREVEWLATHDELTRLPNRRRFMQVLEEHAGIRPLSVLLCDIDHFKLINDRLGHLVGD
RYLAELGRLGQEAFDAVGGTFARFGGEEFVACLPGSSVEDAEAAARRLQEALAEARLPHQ
DGAPLTLSIGIATLEEGALEPDELLQAADDALYRAKSLGRDRIELAAGPHDPSS
>A0A2W1JUI2|diguanylate cyclase|EC 2.7.7.65|Acaryochloris thomasi RCC1774|TrEMBL
MSKWFNRPISVRNRLLTSIGSMLIPVVVLAVGTIGTFNLAFSSFEETEAVILHESFPAAD
LELLLIRVSLLAASIETVEASDSQSDFEQLSQQIDQTLRLLKHEEISGVPERFLPPGREN
LVTAINTQWLEARASGTEFFKPTSASELERQRKTRQIFIRDIEKTVTIIHRLNHLLNSWQ
DQNNLMQAKEVSRKGLILLVIICGIALSLAITTVWALSKTILGPLQILEQAISRFSNGEL
SHRIELQTQDELAQLAQTFNQMATKLEQSQADLQTLATIDGLTGVYNRREFNRWLHIEIE
QARRESHSLSLVMVDIDYFKRLNDKHGHQSGDIALRWIGALLSENVRPGDIVARYGGEEF
AIILPQTTEIEALVIAERIRQSIETQPVEVLNQQLLYVTASLGLATFPEETRDEEELLRQ
ADCALYRAKQAGRNQVQHAGKIPV
>A0A2W7NWS1|diguanylate cyclase|EC 2.7.7.65|Cupriavidus alkaliphilus|TrEMBL
MVAFSLSVMLLLLLLWRGLQLSQGREIESLRHMQAVRAQSMDALLQREAERLLSVRNVAQ
HLLQIQATAPGALDADLRATLAHRDQPVWPVPAHDAAAVYGISAAALGGLDGFTRDEAGL
AADVIVARSLSHLLSAAPEGSGIRRRIAYVSRNGVLAAHPSIPQQEVVSAVRRLAAAPYF
SDSLPSRNPGRRVQWRIAPATVEREQLSLFLSVPVYAEGDFRGVAMLELPQRSLDDQLSR
APFHQANSYLIDREGRLIGASTRNVRAGETMQTALSGPWPAATLDAVFHADSGLLDGAGG
ASGSDLMFRRLRQGGLALVDEIPLHQLWLAGAARLSGVIGAGAAALGILLCATLAVVHSL
FRHYLARGEALRTLAETDALTGLANRRVFAARFAADSARCAAEQRPVSVVMLDIDHFKSI
NDRWGHASGDVVLRAVADALRGGVRKDDLPARLGGEEFAVLLPDTGVDDAAAVAEHLRQR
LEALRCEPAPDAGSTGPIRFTASFGVAAIAPGNGGNLDALLMAADRRLYEAKANGRNQVV
AR
>A0A484XLN7|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MSDTILARVSETLSTEQSLESLVRQLLEMLEIVTDMESTYLTKVDISARLQHILYARNSK
QMQIPEGLSVPWGDTLCKRALDSNAIFSNEVAVRWADCDAAKALGITTYASIPIYLADGS
LYGTLCATSTQKKQLSDRAEQVLRLFAGLIAQYIQKESLLSQLREANAALIAHSYTDALT
GLPNRRAIFENLNTLFSLARHLKRHVIIAFIDLDDFKSINDRYGHETGDRFLIEVGKRLA
AAQTQDDIIGRLGGDEFMVACLSTSGTDDEHAQITPLKTRLSACIAGEYRLDNVHIVYPG
ASLGVIAVDPAENRCRQRIARGGYRDVSG
>A0A7U9RRN8|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MNEKKMAFAERIEQNSKNYFPKDLFNLTVAETMLNQFQFHFGLDTLMTDRHGSILMTIGD
FGDFVPDVVNKPGNKIRVKGRTVCHIYAKYDNVAKEKIDVVTKLLNTYIETLEDYCGKSY
VASEQAVYIDELEQQLEKDADHAKYSSENDPLTGLLNRNHFISHMKELAEREVVPTAAIC
VNINDWKFVDNYFGEEESDRLVVTVAEILRNKAQEAGFAHAVLGRVEGDVFHVLLPLTEE
EEAKAYCDAVQQACDNFEDDKLAPSVAVGCVMRTNVEESFKDILSDAEYAMLENKFVIKN
APGYKERLEKGLGNYS
>A0A6J4FA31|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MTESQKIILLVEDSDIDGTIILGRLSKFPELTCHWVHSLAACREMLAVISVDAILLDLNL
DDAAGPELIEAVRGLCNAAPIVILTNTDDERTSLMALQSGCEDYLVKVKSDGQTIRRTLL
YSMERSRLDLARRTAEETARQREALADLILEIAPEAMLVIDRGGRVVRANQHACQVFGYA
ADGLVGRDLDALVPQDARRHHHERVARFTAGPAASGLRIPSEVRGLRRDGREFPAEVNLA
PLWFDDEAYVVVSVRDLTLAKAAEAASRLNGAIFEHAREGLMITDGDGVVLSVNPAFTAI
TGFEADEAVGASVGFMKSGRHDPAYYRQMWHSLTGEGHWAGEIWNMRRDGSVGPFWLSIS
AVRNADGRISNYVAIYTDIADMKRHEEALHHMAYHDALTGLPNRSLLGDRMRQSLAKARR
SGRMLAVAYIDLDGFKPINDAQGHHAGDMLLTEVVETAALEDVERARDVLQACRAMGVSS
ALDDFGTGYSSLTYLRHLPIDTLKIDRSFVWNLTDDAEDLTIVQGVIVLANGFGREVLAE
GIEKAEHGEILLRLGCQLGQGYRIAPPMPANDFLAWRAAWRPDNSWTA
>A0A6J4FAQ6|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. UT-4|TrEMBL
MNLHSKVTMFFVAIAACLIAILVALSLYAFRSFSIASSSEHIRTAAEIVRVHLTESMING
VIDKRESFLKRLMEVQGLSSAKVVRSPLVVQQFGEGLNRETASDDIELQVLKEGRPRYDI
IETADDTLIRGTIPFVASDRGSPNCLECHQVADGNVLGAVTMMVSIGSLKHKAILTVAGM
IAIVVLFSGFAFVFIRRMILPISQTAHNVEHVVQRALKGDFRGEVEQITNDELGQIAKDM
NRLLRFLDEGLTRIGGNVARLTNRTPSPDENQLDATIDMVDGLTRAAHFKQAIEEDETKA
EIHHRMSRALEAEFGISEYSLYEVVANKNQMVPLFVDGEVEASCRWCDPQILVRSEACRA
KRTGHLVDGIVNPGICYAFQPPHEAGERKHICLPIIQSGAVGNVLQLVAKPGEEAQLEAR
IPFISVYLREAAPVLETKKLMETLRESSLRDPMTGLNNRRFLEEYVETMVANSARRKTDL
AILMLDLDYFKMVNDTYGHDAGDSVIKALAKVLRQCVRSSDLVIRYGGEEFLVILLDTAP
AAADQVSEKIRSAVEALEIHAGTVTLKKTISIGVADFPNDSDTFWQAVKYADVALYQAKE
GGRNRVVRFTKDMWGDDKTY
>A0A484XT61|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MNRQGELVINPGYQFDPQRLKAIALNAREHRGDFVMDGRYYTYRTVGSQSWLLVHEVEQS
ELNNLAFQQCLSTLWGTLCALIALLFCWWSTRAALNAIFMRIAASIRGGTIKPASVEELI
FEEIHSSQQRQEKTAHEALTDGLTGLKNRRAFDADAARCNSEPNNHLAMVDIDNFKMIND
TWGHTVGDLVLKTVAELGSRLRGLENITLYRYGGEEFAVLFQGISAEKALSYLEKWRITV
NTRSFREHDLNVSFSAGLCKMGGTSLPDTLGRADKLLYQAKKSGKNKIIAS
>A0A411ZBC8|diguanylate cyclase|EC 2.7.7.65|Altererythrobacter insulae|TrEMBL
MPLKGLLSGKEGGLFASGRRTGVAGANEMSDTDKLAMLDELEESGLGWFWSTDSQGNLTY
ISGAIAERIERTIPELIGQPLASLFDSKEGDGRSKSLSLKLGSRKPFSGFAVAPSKGNTK
IVIRLAGRPALSKGGVFRGFRGTGADITEEYYREEETARLAKYDSLTGLFNRHRMAHSIE
STLTAFRSAKRNCAIMMLDLDRFKQVNDTLGHAAGDELLKQVASRLERAVEKDCEIGRLG
GDEFQIMLPDIDDRGELGEVAAKVIAMLTQPYTLDEGRCVIGASIGIAVAPHDGLNREEI
VRSADLALYSAKNGGRGQYRFYSGDLENEAIFRRRLEENLQEAIRDEQLFLTYQPMVSAK
SQKVIALEAQTRWDHPQRGEIDHDEFQSIAENSSHVLEVGKWAIMQACEEAVSWPDPLRV
TINVPTKQFASDGFVDSIAEALNETGLAPDRLELEFKESVFLGDNNVVDKVLGQLFKLGV
RLTLDEFGTGYSSLGYLRRAPFDSIKIGENLCPAHLEKGSQEAGLVKAVVALAKALDMTT
IASSIETLPQQKVLADVGVSLLQGSVYAEAVSSEDVFENLSSGGWMIEPASGRASRAKRR
TVLRKIHIIHDDHSYEVTLRNLSKTGALIQGLEDVPIDTQFVVDLGGGQLAVATVLRSNR
DTQGVEFELPLIDDGAGGLCTRHRVSPYELASAGAPLTALSQGNYNSMQGSGLGGDASVP
KFSYAPVGSYEAA
>A0A4Q7DIT4|diguanylate cyclase|EC 2.7.7.65|Cryobacterium sp. SO1|TrEMBL
MSAPDDQLAPLPAGATVPSEPPASDAVRAGADVMADGIADLSLADGGRDLDLPSGFVEIA
DLPVPTSDAELHQQPPVDGAGFARRPTIDTILDECAKANQDGQHHAGAAQAEQVLADPFI
TPAQEARARQLLSGHRLRLGEFEASVRHGLLALEYLSASGDLVGQSKVHCILALAFHETA
LEEPALSHVLGALAAARASGSRTAEFWALSRSSMVHQALGDADRSIELGRQALALADTID
DPEAAFAARNNLGDSYLEIARAHRAKEEDASVALRDGIAVTRAAVTQAVEQRHAFYETIA
RTNLVGLLIERGEYAEARRQAGRSKTIAITNGYRNLAVNNDAQLAEVARAEGRVDLACAM
MEAQVADPSVAEDAALNVKLHRALYQMHQAAGRFEQALEHHEQLHVLMLGLTRQTAGLQS
RMLINSLEIEQARHEAQRSQLEAEMQRIRAEELDKQAHSDPLTRLPNRRALDRQLPEMMS
SARERSEPLCAVMVDMDHFKQVNDEHGHATGDRVLTTMATILGNTTRDTDLAVRVGGEEF
LLVLGNTTIDQAVQICERLLGEVRNHPWGVVTAGLHCTASVGVALLKPDESVSRWLGRAD
AALYEAKASGRNRVELAGSRA
>A0A554XBG9|diguanylate cyclase|EC 2.7.7.65|Tepidimonas taiwanensis|TrEMBL
MESVCAERRVAAGERLGGDGALAEALLAQVADWRWAMDAEFRIVRAEPLAEGRRLPPLPA
LIGYRPWECPALVLDERRRRRHERLLWQCQPFRGVELAWRTDRGRQRWFSISGVPRLDEQ
GHFHGYVGVATDVTARRRVEQSLRDVRAELDATLRALPDLMFEIDGDGVFHGVHAPQPEL
LAVPAERIVGRRDVDLLPPEVVRITHQALDQAREHGAARGHRYRIKLADGVHWFEMSVAR
KAGRDRYVVVVRDITELNALAFYDPLTGLPNRRLLLDRVEQALLRLAREPDWAALLFIDV
DDFKRVNDTLGHAAGDRVLQELAQRMRAVVRSSDPLGRLGGDEFLALLTDLGTDLYSARR
TVQRVGSQLRERLSQPIAWHGGVVTVSLSIGGVLFRGAQQPDRLMQAADQLMYRAKDRGK
NAIAIQLMSALVRRM
>A0A1J1LEM1|diguanylate cyclase|EC 2.7.7.65|Planktothrix tepida PCC 9214|TrEMBL
MLYKKKLFGLATILRPFLNWSYRLLGLPSLDELEAKLQVETIKNEQMKQQQNALYRVLSK
IRASLDIDYVFRTTTKETCKLLGAERVAVYRFHEDWGGEFVSDFEFAESGWIDEEKLGKN
TVWIDSYLQENQGGRYRENQTLVVADVLEAGLSQCHVDVLLQFGIRAYATAPIFTQHKLW
GVLAAYQHSKPREWHDSEVEFLAQVATHLGFAVQQAELLAQTQQKAKDLEKTSEQQQILL
SVISTIRESLDLDILFKTTAREVLKALNADRVGVFRFNPESNYCLGQFVSESVLPVYDSA
LAHPIYDRCFGEKYAMDYQKGRMQVLNNIYEANLKDCHLQLLEQFQIKAQIVAPLMNGQI
LWGLLCIHECDRYREWTNNELQFVEQLAAQFSIALSHSDLLAQTRSQAEKLSQTLQDLKT
ANLKLEKLARRDGLTGIANRRYFDIIFHRNWKAAQEKNHYLTLILFDVDYFKLFNDFYGH
PIGDQCLINIARSVQKILRSTDLLARYGGEEFAIILPNTNPEQANRVADKIQSTVRNLMI
PHANTLNGKSIVTISLGIASQIPNSHQLPQDLITEADQALYSAKKQGRDQWVSWVQPLTV
IS
>A0A5B8R0K4|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MKDSNATVTQLALLQQKLHSAKLALDEVNEDRNAKLQTLLQFIGHLSLACKGQNLELDNK
LAKLRHNLNTFERVDEALPELVDVERLLKGQYHHVMVQLEESRAGLAQVIRQIQRVNSAP
EKLKKEVNYFKQDLAKPFHTVWEYIPKVKQIIGFYDTILQQQFNETEKLDVLPKHRQLAH
ELAQMISEIEFRKDQRDQVLVIKEQLASEVEIDTLLEAYQTILSLLLDNIAREKSASQEF
LYALNDALAAVREVVSESYNHNQRSFQLKTQLNREINSRVDNVGEAIIDTEDIVDLKAQL
TEQLNSIRSALARKEALEQREQALLRKSMETMRKELNELSNEANTYKERLFEQQKLNLLD
SLTQLPNRAALEERMELEYRNYQRHKTPLWIAVADIDHFKSINDSFGHSTGDKTLQVIAM
ALKNSLRDTEFVARYGGEEFVLILPDIDSSDIGQLLNRVREKVKNIPFKFKNQRITVTVS
IGAAQVMGNELIHETFERADAALYKAKHESRDRVVIDV
>A0A518ILV7|diguanylate cyclase|EC 2.7.7.65|Gimesia fumaroli|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGSYMGWPLGIAPLLLLAPITVLAAISSPRICSW
TITVLAVGACFAEIVFRSDISEVKTTYPLSIMSAAVLIGLTLLIDAYIGKLRGKLSQIYN
QNDELVRQLYESQRETKPTSAKSYSNDKGNTKEKPQTDSKENTDAEIGVNYPLLLLTLQD
IGRRISTNQSNESLIPTVISTAKASLQCEYCQVYLWDSKANALKNALPVRNRDKHEYRPV
PNSGVAAWVIENRQIVMRNDAEKDYRLKRILEEDPHMPDAIAPLTVGSELIGLLIIDKVD
IESPTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLLNHATFQDKLQELIKNAE
AQSTTLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPENAIVARYGGEEFIGV
LADHEYSQAAQIAEDLRETLENCPILFEGQQLQVTASFGVTELRHPATTTNELVKVADEY
LYKAKEAGRNQVAGAAPNSNRKHST
>A0A246KJF7|diguanylate cyclase|EC 2.7.7.65|Brevundimonas diminuta|TrEMBL
MPNPTSAVATPSCVSEPSLDPQSLERLRALLNANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRRWLIDLFAPNLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDAAAFGLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRAGLMEWSQKTLFRILASGGVDGAGALGASPFGLWIRHRADFLFDGSPHLTRLNATME
RIDTELLPRFTPDAIPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHR
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGA
>A0A4Q9RCB4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas kirkiae|TrEMBL
MQQISNEELSQEWTSLVERFSPQAASILQETAKEKSADLARHFYAYMLSDSHSASFLSHE
QVKTRLSKSMQQWVITVFTPIAQIDDLQTVIDLQRKIGEVHARIELPVSLVLRGSRVLKE
RLRHLLALRGLSDELYRETICLGSDIIDLAIEIICFAFSQSHDRNSRAEEAYRLFSVSQN
IGTEKERQRGALLDWENQLMFDLAMGNTGDNLPKLASSEFGLWFRHKASHAFQSSPESES
ILEYIRQIDTALQDIPDGQQPGSDHGLSVLREIRQQTRAIKFLLDTLFEQANDLEAGRDV
LTRLLNRKFLPVVMSKEILYSRQSSNTFGVLAIDVDHFKTINDRYGHDAGDSILQQVATL
LAGNTRGGDYAFRLGGEEFLVVLVDINPEKGIIAAEKLRESVARERFKLPQGGDLKVTIS
IGMAVHNGHPDYEKLLQQADQALYQAKATGRNRSVLYK
>A0A354XKK3|diguanylate cyclase|EC 2.7.7.65|Halomonas sp|TrEMBL
MRYKDKHQLAAEWQSLLERTPLALRQAVETLVESRRDIFADHFYQVMLEDPHASLFLSNE
QVKNRLHPSMQRWLSAMFAVEHADFESLVEQQEKVGQVHARIDIPVNLVLNGARQLKQAL
YEHINSTFSAELSSGDAAVYVSDHIDMAMEIMSHAYSVANNRNTRMEEAYKLFSLTQSIG
DERERQRSALLDWENALMFAVAAQQATTALPRLASSEFGLWYHHKACHAFEGAPEITTIS
QHVRRVDEEWLAQLGDSDSQRRLTALSSIRDAARTILMLLDDVLDRASGLEAGRDSLTRL
LNRKFLSVVL
>A0A1B7L8J2|diguanylate cyclase|EC 2.7.7.65|Mangrovibacter phragmitis|TrEMBL
MFAKLTTIKNPQKLVTLCFTLVFFGASLLMWREGAMLEQAYISDQRNTLDNIASSLDKQL
QHSVDILFFYQQAMEFSLDTPFITNNTHPGMKAFNRERHKPWWSVSYDQRRTIPVFGVSE
AFVEQHSDLMRNNNTIDRELSAALELSYLLPLSRYASTLQFNTWYISRAGMFVSSNGHVL
DKSLQTTFQRMLSRPSFARQSLANNPGRAVCWSYYQDKENPEYQVVTASIPLDYEGHWYG
VIGMDFTLDVLHGYLKGIAEQHSTTDGAVYLLDSKLTALTSSMGRHGEHLVMSPVDQARL
AQDMSSNTVGALRMQNRFITWAKLDSFDGVLIREHNLYQGFQGDFGHIIMLLLFVWVMFT
VLLTGTWYFIRRLVINMSVMQNTLSWRANYDTMTRLFNRGAFIDQAQQLSASCRPNTQPF
SVIQLDLDHFKSINDTWGHQAGDKVLKHVAAVISNTVRKQDIAGRVGGEEFCIVMPGASI
ADATQAAERIRERLASKPVVYSAEVLIAISASFGVSSSTEKGDYDFEHLQSVADKRLYAA
KEGGRNRVCAED
>A0A679JWL8|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MGLKLRLGRFTWSARTWIVLGVLAPIGMLITSGVMLLDMRRDAWDKAEQTSRNLLRVIER
DIARNFEIIDLSIQGVVDGLNVPGVRNVSPELRQLILFDRAASARDMGVMLVLDENGDTV
IDAASVTPRKLNNSDRDYFKAQKARADLGLYISPPVVSRLLGTPVLVLSRRINKPDGSFG
GIVLGSLSLSYFHRLFDRIGLGPYGAINLYRSDGMRIVRHPYLESDIGSSIAGTPTFERF
RREGSGSFVGTSPRDGSERHFAFTRIGDLPFILNVTLSAYEIEAEWRGKALVISLIVVLL
CGLTIGLSLLFWRELRRRAAIQAELERLSRTDMLTGLPNRRAFEEMVARLWTSARLQGTP
FSLLVVDADHFKRYNDRHGHAVGDRVLQGIGRCLSASLRRAGDIVCRVGGEEFVLLLPNA
DGAAALGAAERVHARMSTLSVPSAEIEAGAITVSVGVASALPSAGGSTDPFDLYRRADAA
LYAAKAAGRNRTCCAAPEGAAHPPAAPHGVAD
>A0A2H6IT26|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin09|TrEMBL
MTENDNKNLFHSHFKSYIWVVAAVWTIIVAVSLVWNLWWSIPKEHILIMSAVHVFMWVLV
LCGIFVGGRKLIRTDQMRIRAAKEMKDLNTELSVLFTISAAISRTIDLNDLLSSILTTIV
KIDIFKVEPKGGIFILEGNRMKLVSHLGHTDSFLNTHKKMSIGECLCGKAAETGAIIISK
NCMDDPRHTIVYPGMTPHGHIIIPLKSKNKVVGVLYLYLETNFDMDEAKLGMFTSIGDQI
GLAVVNARLYERTKRSSLHDPLTGLANRRFMAIILKRNFANSVRFKRPLSVIMLDIDHFK
AYNDTHGHNKGDNALVDVAKVLLKESREIDLAVRYGGEEFLVLLPETDLEGARDVAERIR
QTIEATTNVTVSLGVTSYREKMHQEEIVIKADKALYMAKNNGRNRVEVSK
>A0A829AG52|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE119|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A377NHK6|diguanylate cyclase|EC 2.7.7.65|Ewingella americana|TrEMBL
MPCALADVVVRYGGEEFLVVMSNVTQDYAVRMAERIQNKVLSLNIPHSFNADVSTHVTVS
AGLSTLHDGDFPSALTVADQLLYNAKNSGRNKILYSWEAIPDGEKTHIAL
>A0A1V5HXX7|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA155|TrEMBL
MVTWHYETEILAAILFIVIFLDAHHRLNRGQRRDWVFLLTLLAGFLFCLVDILDSIVVLW
TSTPWILFTIRTLYFFASTIPALMYFLYLCAIAYSEQDRKYNLWVLFGIVASASFIVALV
INIGTHLMFYFKDDGTYVRGPLFYLSYILSGLYFLLYVLLLLFNVRKITDKRLLAVLCLI
PALAAIGLVVQTFVPGWLVLGPSYALALLIAYLFIQTQEANQVYGRLSKDASTDPLTGLG
NRLAYENVLVPVLETPLVENCALILLDVDGLKKINDRYGHPKGDEALQKVATVLKEQIQD
AKVIARIGGDEFALVVLDQDWAQLEPRIKALLKAVKAESAPNKKSYDLSFCVGVAYKQTD
ERDVNTLYHQADAALYAAKHEGKSSYVLYQD
>A0A1S0ZFW9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSAAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A447Q3G5|diguanylate cyclase|EC 2.7.7.65|Serratia plymuthica|TrEMBL
MGKLMNARINAKHGLPVTLQLITLFLLAFLLSLLGIFTRPMGSLSLFWPVNAILLGLLLR
KPAYATPLGWLTTYLGMIAADLTTGEALPLAMWLNACNMSLIATGYGVMLLLPQSQRRMG
KPQAILYMFTASLSGAAVASTLSILRNDSLYNNTVITAWLAWFSEQFSTNLLLLPVFLAA
PRLKQLLRMPINWPLRAGMPLLALLFSLIFSVYIGGPGAIAFPIPALLWCAVRYQLFTVT
LLTLLTGMTEISSISANLMLYETPNNHNAFLDTLMSARLGIAMLVMGPLILASSIAVNRK
LMRRLEHSANHDFLTGVLARSALTQKAGELLEHKYKSKEAVSLLLIDIDHFKRINDTHGH
VVGDQVLASFAHIVRRELRHDQLFGRLGGEEFAIMLPRALAAQGVALAEHLRQLVQKTDL
YPGGKAPLKITISVGVASLAMNEVKSLEQLMNMADIALYRAKSQGRNRVESFNVVSGNSV
GHIMFR
>A0A4P8HX13|diguanylate cyclase|EC 2.7.7.65|Massilia umbonata|TrEMBL
MSQAFTAGAEPEFSLTTFKVRVLLVDDQLLVVEAVRRMLSDQPDIEFHFVTNPAAAIDCA
ERLQPTVILQDLVMPGWDGFDLIRRYRASAQLEHVPVIVLSARDEAASKAHGFAVGANDY
LVKLPDRLELLARVRYHSGAYISRLQRDEAFRFLRESQKHLAEANIELQKLAALDSLTGI
ANRRRFDETLHHEWQRAQRERRPLSLLLCDIDCFKLYNDTFGHLAGDLCLKKAAAVLTAC
LKRPADLAARYGGEEFALVLPDTDEAGARSVAEYCLRALAELGIDNPQAPHRIVTMSIGM
ATLIPASGTAPADLVEYADRALYSAKGDGRNRASGAF
>A0A1V5I499|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.BinA120|TrEMBL
MDERIDILKNAGLFAKLKESELAVISRNSELMRVPSGYVIFRESETADALYIVRSGEISI
NRKANGETTTIATFIEGETFGEFDLFENSPRTATAVAEMDSEVIRFPAEGSSFRDLLERH
GGLAARILHRFLATVAARIRYTNSLISEKTQWVEELRRQIHYDKLTGLYNRSYLDEEALP
ALKRGEGEFALVVIKPDNFKDINDNYGHEAGDKMLRILARVFGAAIGPKNTGIRFRGDEF
LAILPGAGEEDALLIARKLMAEFRAADAAGVTGNADFRLTASAGIAMCPRHCSCADAVGV
AFEKMLEARNSGGDRLVATLDTNGSGG
>A0A1X3LJC4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TA054|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A839WY36|diguanylate cyclase|EC 2.7.7.65|Luteimonas sp. RC10|TrEMBL
MPDRDDLHHRARAAALLFPSRIRRMRMLGAVLCALPITSVLAERGAPAWLWIALAINAVL
WPQLAWLRAQRAHDPVATEYRNLLVDAVVGGLWIAAIAVNLLPTVAIASVLASDRLAAGG
WRLFWRAAIVFALAFVAGWALAGYPFAPETSSRTLLACIPLLVGYPIALSLVTYRLGRTI
ARQNRELERSNRTDSGSDLPNRRHFDVRVRDALSRFDRHGDPATLLMIDIDAFKSINDHY
GHGVGDLVLRRVADVLRTAAGATDTPARIGGDEFAILLAPAGPARAAAVAEYVRAGIAAL
GFDGHPTLACTASIGVSTTRPEFGSPPDWLRDADSALYRAKAAGRNRVTVA
>A0A1V5UFT9|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin239|TrEMBL
MYDVFLRDNDSVYFLVEGSHIITDKKLIRLYGSCKMIGTPKCAKTIDELLMYIDCKSEIC
DIRGAKQYLDELRRAINSDQIKTVLYLPLDFGSGMKKYLELKIFKMFERDVSIVVVNQID
MQKVNVETLYFESYKDSLMNLFNYSTLLLHLDKTTGNHFFGFIDIDYFKIINDTYGHKVG
DEVLAEIGHKLIDVSDEHVIMYRKSGDEFIFMTLDLDAKQTRALAERIQEAIRSIKLPNI
DVDCSIGVVEYRDGNGFFDVYQAIDLADIAMYRSKAKGRGTVTYFSEKEVKEILKHGPLE
KTLKDLESKPR
>A0A173WKL5|diguanylate cyclase|EC 2.7.7.65|Mitsuokella jalaludinii|TrEMBL
MPDIYSDVPVAYAVYKLIFAEDGKTVVDTQYVFVNHIYCEMVGVDREMLLGKRFRSFYEN
ADPRWMEYCAQAVEKGEVIRDCIYAPEIGHWLDFSIMPLKEPGYVAYTFMNVDIDRARQM
QMKRNYTTNDIILCISKILSSEETYEVAMNHALQELSRILHPDRLYILETDGKTVSNTFE
WCAPGVTPEIDTLQHLDYEQYIGGWEKFLKHATSVIIEDIEVLKADDPVDYWNLKRQGIE
RIIDAPIYHAGKLIGYLGADNYERSEMINTVAILETVSYFISSKIMNHRLMAELEHASRY
DALTGLQNRNACMEKIDFLTKYSSSVGIVYADVNGLKEINDTLGHQAGDAALRQAARLLT
KCYGLENTYRIGGDEFLVLVPLVTELDFKTSVLRLRELAAGKADLSIAIGSEWVADTAHL
ERAITKTDQRMYCDKVEYYNRRGKKRETRHDLNAFRRMAAKNLPIAD
>A0A4D8PZW7|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKTAILAATLSSLWTDTEPAVRERVTAIALAEAEAISKVFYAILLDRPDSNTFL
SHTLVQERLRPSLARWITALFTASTDTAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSARLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNTVVSFYAHEDSNHASPPAIESSDFGLWLNHKAELTFGRVT
ELDLIRDRTNRISAKVSAAVEGDWITPAFVKELNNDVTEIAYILGTIIEKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLILLTEMDEAALRVKADQLRRMVEEHRFHGAGNGLRVTASI
GAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVVA
>A0A447SV45|diguanylate cyclase|EC 2.7.7.65|Legionella sainthelensi|TrEMBL
MIPPGIPENETERLATLYKLHILETEQEERFDRVTRIACKLFEVPISVISFLEAERQWMK
STQGLAIKQAPRKTSFCGHVILSNKIMVVEDATQDIRFHDNPFVIGPPYFRFYLGCPLKI
KTHNVGVICLIDDKPRPIMEVDQDVVYDLAQMVEMELESLHLAITDELTGLTNRRGFLKL
ASHLFHKCQQENKEFALLFFDLDKFKHINDKFGHAEGDKVLKVFSNSLLQNFRCYDVIAR
LGGDEFCVFCTGLNQQDVTGIVNRLQASLKSLQVKDYTIEFSVGCVQYNQKVHQSLEDML
ALADSEMYVVKKGK
>A0A7L6IJF1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00570|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A1A8THY4|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MHSDSPRQAHALLHKAIPLMRKMDIAPTPYNYGIWYEYVRQSSPKLNHLVDLTIGRLGSL
PSFISKELFHQFIVSEEARYNNEHKDKLEELVNTVSSETHTMSASLAELQSVMDKSRKVL
NRADRQKHLDKVVRYLDHSTKKAMADAEQFSSALNQVNAEVLQLKAQLDEMKNNADLDPL
TQLLNQKGLERQLFTLIPSSEDDLSLLMLDIDHLKEINNQYGRRAGTALICHIGRILTSK
KLDNTTLARLDGGTFAIILNEATLDTAIEYAEMLRNHLNQQRFKSRAGQGIIEQIKVSFG
VATVIGQESPNNLIARASGYLDNAKRQGRNRTASR
>A0A1A8TA18|diguanylate cyclase|EC 2.7.7.65|Marinomonas aquimarina|TrEMBL
MNKPSRTLSFISLTLLSVVFTLTLALLNTVRFDDSLRAIFNRDHGLYDQALSERSQSYLL
NVLPLMEPLQSEPSDRDDLRARALEQLDLAYAYLNVGRYLERYACVSISLEQILLLRERV
AEGGNQPFLFDELSQVLSCYSLINRNQNELKANMIERALVASRSNQFWMNVGIIVVYALA
IMLWFLLELQHRRGHKSETEKKAWQNRAMTDHLTSTYNRMALHESLENLVSEWPDSQNTV
GLVFYDIDHFKQFNDTFGHVAGDDALRDVTAAVNALLPGHTEHFRFGGEEFFIVNHGQSH
AEVVKLAEQMLAAVQDLNIHHPKSTTGILTVSVGVYMLEQREYSVDELIKKVDQLLYVAK
QHGRNRVVDEFVSHEEA
>A0A447IE29|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MLKGPSQGHRWKIDLDIPLVEAFVVCVMVLAACLVGIHSRFLFSLASIWPANALLLGWLL
VRPRANRLLVWIGAIIGYGLGDLYAGSSLLSIVLLNGANLVGIAAGFTLARWRGVTPLRL
GSPEDVVMTIVVVAVASVTTAVAGGLSGPILFGMPAGSAFGIWLAAEFVNYALYLPLVLA
AASGSLRFLSRSSQQRLHQYGALACLSVLILSMSGIGGPGAPTYVVPGLLWCAIVFRPFA
SAILTAATCTWILIAVPLGYFRLPYELVTPAEVTSFRLSIGMMAMGAFAVSAISSAWRGM
NTELRHLAAHDPLTGVLNRGAFLTRLNQQVSGRNGAFGLLMLDVDHFKAINDSFGHAAGD
NALRTLAEVMRQALPQQAIIGRLGGEEFAAILARPDDAANLATAEALRSAIAATAILTPD
GVAIHATVSIGVGMGTSGCNQTELLAVTDAALYAAKHGGRNLVVSAAPCTHRPTEAPKTN
PSAPRRRNVIRRTM
>A0A380U7Q7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MAYTPFNSPVDFIHDLSKADSLQAVLDTIAYWISHVFDADRASITLQDTEEYLKLYSISG
NHAIPMDFKIPIGQTFVGRVFAQSQLIICDDLAQSDELDCKILSEHGMGTCMDAPMIHNG
VCIGTLNVADQRKHHYTLQQAILLQSLATWLALNIKLHLQVQEMAVLASTDELTGTFNRR
EFVQESNQTMQHFSHARVPFTIGILDIDHFKQLNDCYGHTAGDHVLKKMTKKIRSVLRDE
DFLARIGGEEFAIILPACLGDEAMRVFKRICSTIEAMEVHYEQEVLCFTVSIGVAEVGKH
DADAEDAFKRADKALYCAKQAGRNRIHFAN
>A0A2X2ILS6|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MKEAALRSRTQTLTPKKPALLHWLVQSPQQADDAQFQRQMRLTLVPSPVTPWLNAAGVAL
LLLAYAWLSHMTIGAALLVLLVLLTGVRWWLARVSPPRRPTAMLVTVLLWCALVGTIALL
AMLSGRMVLILFAGLLITALTFWLIQRHAAAPRFVLLEVMLLTLPYLLAAPLSRVQNLFL
LADIIPLWLLLAHGLIAFYHRQVAQQVTLTAEKQQAAQRDHLTGFLNRAGGEAVMQEICS
PSPTIHPLSHLFMIEFTPLAALYQSHGVLIGDDVLRTIGERLKMLVRPSDFVCRYSGGQF
LILVHGLPYGSEGEFLARIVPPLEVPYDFGAFGEVTLQLNSGALALTQDYQTVENLMAAA
QQALVINRKE
>A0A447NME6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sanjuan|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSKPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1C3J1D3|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MINILSDNVFRQINIFLSVFCLAATLLSFISYHMIMDQNYVITPDRFPTLVNTDQEHNGG
TKGVLYKSEDTIELQCDFKRTYSSPFCEIEFVISTEGKGLDLSVYDSVTINIDYEGQEQP
RFRFYIRNYDENYSVQGDAMSNKFNRLDFSLPDRKHIDLDYFNVPLWWIDYYNHPITNSA
VDVTNAVSVELGLGASTLDGHHKLTVQSIVFHGKTIDKFVLGKLLISLWVLYAIYYISCA
LYLARRTRTDAAQQQRLLTQEIEELKIKATTDPLTGCRNRTEALDAFYDFEWLAQQGKTI
HIALFDLDHFKQINDQHGHEVGDKVLIQFVATANESLGEQYLLYRWGGEEFLLVCLEQTA
LQCNESINNLYLAIDQSVWPKALKVTTSTGVTQLKQHESIRSAIKRADKALYQAKDNGRN
QVAKLH
>A0A1C3IR64|diguanylate cyclase|EC 2.7.7.65|Vibrio atlanticus|TrEMBL
MNNNRVLGSFFLVVLISVVLGLYLLYPTYDDDLQTIRPETPGAYSPEKELSATQYGAELI
EILNVSRGDPKLASQKLETLKATSPTQHKAIYRGYELMILSNLAQHDLDKQAVSEYTRQI
KALAQREDMGWLKAQSLVELAIEQMSQGELVEAESQVKAAISIAESIQYEELLIKAYNTV
GSIKNIQNDFSEAQYFFHKGLNLGKKYPRHIYNSKLMSNMALLYIYLEDWPKALKLIEQA
KKLYIKSGLRDGSTIGVLYVNESFAYLRSGDLVKGREAYKSATKFNDDSVSERYKILLLK
AQSEVLLAEKNFELARKVTNQCIGYPGVAKYTLQLGQCYLNRALANIGLNQDNFVFFDLK
RSSTMFDIVGSRSWKVLGFKALAEYYESKGNSEIGLRYFKLYYKGNKALLFEKRQSDIFL
LEQDFATASLAKENELLNAEKELAEMTLDKQSLKDRIVVVLGVMVIISFAVLLVRLCTMH
KTNKELVKQSTRCELTGLFNRRYLEQLLTQPMPYRLSPFGYTLAILDLDQFKRVNDTYGH
DIGDQVLVEVAKRIERALSTNDVLARWGGEEFVLLLAGTQDPDEQLEMIRQTIADQTIET
YSGPLALTTSIGATIHLTYQELNSSTYKQHLKSADDALYQAKQSGRNQVVIA
>A0A174AF51|diguanylate cyclase|EC 2.7.7.65|Faecalicatena contorta|TrEMBL
MIPYSNYFVENYHTYYEDIADRNLKSLRLITTLGFLMGVPLILVSLFLENFLKATVPYTI
ITAASVFLNILAKTSLKAYKRLIPAALYTMAAIILGVSVYLGTIMQPELNAVAFIVFLVG
LPLFIVDIPSRICMFMGIFCVIFCMLSKIYKTPYTASYDIINTVVFYLLSIFTSHQFNYL
NFRQIMSNNILEMQRDTDKLTGLWNSGFCERKITSHLSLANAQGALLVIDIDNFKLVNDS
RGHDCGDQVLKEVGAVLQETFRSSDIIGRIGGDEFLIFLPDCSSDDVPRDRIVQFLEAIN
AINTAADRELPLIGASIGIALAPEDRCTFRELFKHADEALYLSKQNGKNQYAFYHILP
>A0A6L5EEB5|diguanylate cyclase|EC 2.7.7.65|Citrobacter telavivensis|TrEMBL
MIKKAVEIDAILLELNQSIDTHYQWLVKMFHCVVTEDASQADIIATNAHCLCHFGQWLKN
HTVHSHEEWEHFREMEYAHAKMHESGRELMLAVIEKRWRGTHFDHFQDSLLSFTGKVMEY
KISLVNLRSNMDILTGLPGRRMLDETFDRQLKDAAPLELYLLLLDIDRFKSINDGYGHLV
GDIVLRMLATNLTAWTRSDETAYRYGGEEFVIVIRAKSDEEARQAGLRICQAIASTTIHY
PGGTLDITATGGITRGWPGESLNTVLGRADKAMYEGKQTGRNRCMFIDKDQRMTNVVNVA
PVHAVFTKQAVS
>I4EVB8|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MRRDGAPELPDVGSENRLAAFCLAGLLGVGAVLGLLNLVIDGAVRAGPTRPVYVAAMVLL
LTLGLVVLVRRRVTAAATAAIVVTGDLVYVVLAESVTDPLRYASPLMLLLCCVAAAWFLG
PRMLALHMVLVVGACGAALSRSFPDTAGLVLQVTVAAAVLDLMTLVVFLLRRRVQRLLVH
TVALSSTDPLTGLANRRSLVESAPRIWKQARRDGQRVAALVLDLDHFKRLNDAFGHAAGD
DVLRCVSAALSATVRPADVLARTGGEELVVLGLVADHSEARHLAERLRSAVAASGSEEHR
RVTVSIGVALTRPGDGEDPADGLWRLIDRADAAMYQAKQDGRDQVALATAAVVPAPRVPG
EPAPRAASGRP
>A0A6M1DVQ7|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNTMNDENFYQKKVVSNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPMAFSSTQLSVLLSLPV
LVVYPLLFAWVSYKTLIRLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLCLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A7D6WVG5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMRNTKEIDAILIELNKSIDAHYKWLVTMFRCVVSSDVTQPDIMGENSHFACRFGQWLNN
QSRYNEDDCSYVSKISATHEKMHLSGKKLLMAIVENRSHSWHFDSFQDALLAFTSSVMDY
KIYLLSIRSNIDALTGLPGRRMLDESFDRQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDVVLRALASNLLSWTRYDEAAYRYGGEEFIIIIRTKTDEQACQAGLRLCRLIGQKKIPY
AEGEIGITVTAGITRVQQGETLDTALGRADRAMYQGKQTGRNRCMFMDENEQIALVDTND
GTSYPLSA
>A0A379HJS2|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MPVMEQFLSSPTYADPDSLEGQMTMQDADRQKVLDGYQILDSGYEAGFDRITELARTVFE
APVAVICFIDKDRQWFKSHPGFDKRETQLEHAICRFTVLSDKALLIPDALADERTRDNPY
VTGPDQWRAYAGAPLIAPGGVRIGTVSIFDRKPRDFTPRDEDILQQLAAIVMHNLELRRV
ADNDWLTGVPGRGAFERRSRALLSAGSGSGSGDGSADGHRNALIVFDLDFFKQLNDTYGH
AAGDEVLKEVSRTCQAALRENDAFSRIGGEEFSVLLPATAPDVAGKVARRLQQCIAAMPR
DRLSKYLPDTTSITASFGVTMVTDGEFSIKHALRRADAALYAAKERGRNCVVCSWDLATA
EQSYRKSL
>A0A7W3D789|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQENERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMIAHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSVPVEVMKTHPAQAIPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A133L7U8|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MLSGSEMEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHA
QSALFLNTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNR
GARKLKDELYRVLKTKADDSSSLLSRAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQY
RLQTIYDDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHIL
GNSNLLKEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEAL
VKQENGKDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGD
LTLKNVAAVIHDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASA
TETFSITVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEIYQE
>A0A634NC65|diguanylate cyclase|EC 2.7.7.65|Salmonella senftenberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A514ETA9|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MTNWAYGITVCLTITSGIAMLMASSAETAERRAVQQRQIFDQLTESVETESWELSDLARA
YVINKNPDLLQEYRQQAHSLKTIEQRLEKLKDQGATSQELLLLREGLQIADELQDEQQTA
LASIERGADNEAIALLYGKPYEQDLDRVQTQIDHFRLMLEGRAASAIAQATAKSHTWRTL
SEIMVALTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPRFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFEDVIKVAELFAPNIAPA
IPGRLYVLETNPWQLRCVAQWLSPPDEPEVFYPDNCWAVRRGLSHPPVNGEPDIACSHLP
EACIHQSLCVPLVAQGEAIGLLSFRNVTSATAPSRAYLELMAEALGLALANQRLRSALLE
KALFDSLTGLRNRHHLDDALNTQINLAVQNHTPLSCLMIDIDHFKMINDRYGHEAGDLVI
KSVAAIVQRAVHDRGMAFRYGGEEFLALLAGASEESARTCAQEIYDNVRSLTLRDGLNDI
GQVDVSIGIASFPQHTQSDSLLRAADAALYRAKEQGRSRIVSFGMLKTD
>A0A1V4VTJ9|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaB.Bin104|TrEMBL
MQSRQSIMHVIYTWLVAALAAWQLYLLFPALDLDKGRDLTYLIFLGMMAEWLTVSLPQGQ
LSSNFALVLSTFLIFGPAATAWVSGLATILGLGIANRGVPVRTTLFNACQNVMAAVAAGY
IFKLCGGVPGLVGTSNIFPLVAFTTSYIFTNHLLVYFYLLPKRRFTPYTIWLDALKWDGI
TYLLTVPMGLLVAMIYGYTGLFGILLLFSFILTLQLILRFYVRLHFSNRELTAFYEVARL
LEKDPRLEEVLNFVLASVRKVFPYHSGVAYLRSSNGSAFLPVVASGPYSKQLHNTAVYQD
EGLIGRTLADRKPVIIFDSRHDPRVGNEAGLCRVMRSLLIIPLYSGKEANGVIVLGEKGP
MSFDEKHLHIMVVLGGQAAIAAEKSALSHSLEFAASRDALTGLLISSVFYQAAAVVCEET
GDKEAAVGLMLIDVDHFKIFNERYGRLHGDRLLAELAGLIEANISGDELAGRYGGDEFAI
LLPNARIRRLVDVAARLIEEIRSCYFLEDAGVKARITVSIGIAEFPRDASNAAGLFRAAQ
WALDNAKKDGRDHVSAAIVSMLGLSR
>A0A5E5AUR0|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MKRKLLSAISLTGRLRLQNLAIVCAVIVLCGGLLCLAWGTYRRASDSALALDALRATLLA
MEKASAERGPANAVLGADLPLPASSVTALRNAREATNERLEELLSALSSNDCNQCASGLR
AVERARLDLAAASANVDLLVQRPREMRSDASVRDAVERMVRVIADFTPVASSRIDIVSRG
APGALHYVILARLAADLREYAGQLGSHFTAALTTRQSLTEADQRAIERTLGRIDQLRDMI
GARVNEPPELGPDSLSGLNAQYFGTGLHYVATVRTLATQPNPPVLTTAEFARQYVPTMRA
ITDLRDSMLRLAQRKVELQRAQAMRWLILTSLAEAVLVLVIIVAMRNFRRTVVLPFESAT
RFVDDLAQGNLDATVPVDGVPMKRAQVRAVFDALRVLRLNAVELVQLRRERARLVGELEM
SSDTDPLTRLMNWRAFERQAQALCAMRTPGHIALIKFDIDNFTQLNAAWGHSVGDDVLRR
VGAVCLNTCQPGDVVARLGADAFVILARVLDESRARQFAELLRGRIEATTLALPNGETLT
LTASFGIAMADPATFDVTFDVNDRRTGALTSVSALLSQAERQLHAARQAKRRAID
>A0A8G0WMY2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MSVDLQALYPKLIHLMLDTVFVVDRNNQIVFVSDACEALLGYRAEELTGTPITDYIHPED
LTVTRASIIRVMNGQSHVDFRNRYIRKDGGIVHILWAAFWSEEVGARIGVARDVTALRHA
EEELRFLAHHDPLTQLTNRSIFNDRLESALRAAHRHQNALALLFLDVNDFKGINDVYGHA
VGDRVLCSIARRLEGCVRETDTVARMGGDEFTVLLTDIQSQDAVAEKVTQIIATLAEPLG
AEFDGIDMPSCSVGVAFYPTDGEDADTLLSHADGQMYRMKRRRSVPG
>A0A8G0SHA3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. S11A 273|TrEMBL
MPRSALFSQRSLILTLLLLLGCGFLATSLLSYFASRSSIRDNIVNTELPLTSDTVYSEIQ
KDLVRPILISSMMAHDTFLRDWALAGERDPTQLSRYLNEVMAQYHAYTAYFVSSASGNYY
QAQKGVLKQINPQEPRDAWYFRVLEMEAPYEINVDLDMANQDKLTVFINYRVHDYHGKFI
GVTGIGLSVEAVVRLIDDYQQRYQRQVYFVDRQGQVVLTGSKGGAHGARTGQALRELDGV
RELLKQMPTPVSGSYEYLSRNGHSHFLNVRLVPELNWYLFVDKREDGALDNIRQSLYLNL
AICTIIGLVVLSLLNAMVKRHQDNIETLATLDSLTGLPNRRGFDLLAAQALNEALREPKR
LVALLIDLDHFKQLNDTHGHLAGDEVLRQFAHVLENCLRQADIICRWGGEEFIVLLKDTD
ATHAQEVAEKIRLHTEQRAFNFADTVIHLTTSIGLSSLQPDDTLHSLIARADHALYRAKQ
SGRNRVCVEMSRSDYE
>A0A239SF81|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MTDPSTDPITRSHAQKGRDFSRRVLGLRSLGCVLSAIAVFTAIRHAGASHFGYGIWALNA
FLWPAFAHAIAMSSADPVSAERRNLLCDSAFGGGWVVAMQCSGVPSAVLVSVLLMHNASA
GGYRLLRDGILAMLVGGILTGTVLGFTIRTDIPFSELVASLPLLLIYPTLVGLTSYRLAK
RLSKSERTLRRISDQDDLTSLLNRRSWMRALTNCFAEKRLGRTGTASIALIDIDGFKEIN
DLHGHLQGDSLIRILSDVLSTELGSHDVSGRYGGDEFCVLFDGQSAEKARRKLEKVCTVF
SEATEGLDSARAVTLSAGVANYTVNLVSPTAWLAMADHALYTAKRSGKDRIVIADIDVGF
SGVVLH
>A0A239SFP1|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MSHTLPPRRTTDSTDSLYSSDRLAQTAHALWRTSGSGGMGCGVDRVDVVDADAGAEAIAS
PYLPSSPGRGRIDSVADVFDRECTWLHARSAVTSESPAKSASSPSPFVAFAPGASLASAT
RFEHHESFEPFLQLPNSRPEPSPSTALLSSTRWALPTRRDMTASGHDSSDANDLNDARAR
LLRSTGSPIGRTASVGLDEAERLAALRRYEILDTPPEPAFDRIVRLASHVLGAPISLVSL
IDESRQWFKARRGIDASQTPRSMAFCAHAILSDDVLVVPDARADRRFADNPLVTGDPNIR
FYAGAPLRTPEGHRLGTLCVIDRRPRDLDDEKRGLLADLSSLVVDELELRRVNRVLGDMA
MRDGLTGLLNRRAFLMQADRLFAVARAQQRRLSVLMLDIDHFKGINDTWGHAIGDRVIVE
LTLVLRAALRKSTVIGRLGGEEFAVLLPETDAQRALQAAERMLVAINGASVPGPNGNAPV
RFSASIGVASLGPDDADFSTLLQRADRALYAAKQGGRNRVAVL
>A0A8B6LPY7|diguanylate cyclase|EC 2.7.7.65|Variovorax sp. SRS16|TrEMBL
MSSASDLESMFDLAPVSLWLEDYSGLKRLFDQWRAQGVEDLVAHLGAEPGRVQECMSRLQ
VMRVNQSTLALFGAATQEELLSRLDSVFRGDMADSVIHELDLLWRGQLSFDNQTVNYALD
GRRLDVHVHVRVLPGHEAAWDRVLVSLHDVTERVQAERQRAESERYARGLFDHSPVSLWV
EDFSAVKTLLDDIRARGISDFATFIKVHPEFVTRCMQEIRVIDVNHETLRMFAAADKNTL
LKHISRIFRDEMRESFGDQLQDLWNGKTLQQREVLNYSLSGEPVNIHMQFAVLEDHLDTW
DLVLVSLVDITARKKAEAYLEYLGKHDVLTQLHNRTFYTEELNRLSRKGPWPVSVLAIDL
NGLKNINDEEGHAAGDALLRRVGEVLSKAVDAPSWPARIGGDEFAILLPMTDERGAEAMR
ERVMSLLDLNNQFYAGQNGHVLSLAIGQATCSAGDQLDLALMRADKAMYEDKARHYDGH
>A0A0P0RDB0|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia caribensis MBA4|TrEMBL
MDFDQIGARDQGGSTSTSADRANAALEAARAALETAALSDVPIMVLLVDDQAIVAEAVRR
ALANEDGIDLHYCASADEAIHAATHTRPTVILQDLVMPGIDGLTLVKAYRTNAKLRDVPI
IVLSTKEEPTIKSAAFAAGANDYLVKLPDRMELVARIRYHSRSYVNLLQRDEAYRALRES
QQQLLEANLELRKLTQSDGLTGLSNRRYLDEYLSAEWRRGMRAQTEVSMLMIDVDNFKPY
NDTYGHVAGDEVLKQIASTVEGCLGRPGDLAARFGGEEFAVVLPGTSAGGTRLLAEKIRL
EVEALRIAHAGSPSGQYVTISVGCATQVPAPDAPMTALIEAADLALYRAKRDGKNRVAAM
ESGRSETRSTAE
>A0A239SI96|diguanylate cyclase|EC 2.7.7.65|Pandoraea sputorum|TrEMBL
MSIPAVFISIAILSCVMSVAVLGSLYQAHVPGVRLWSVASALLAVTSALLLSGTSDIVVA
TSSSLLMIASLLGVQGFRQFLNTRPDYAWEYVAIAAILGLLMYWTFVSPHVDARSAMISG
VIAYVRFNIGWMVLRHRPPGRPKYAYYFVSVAATLGAVVHGVRSIAYALGLVHETVFLEP
TPLNVLFLGMATLTLPSLSVGMVLLAHDRLADRMERLATYDDLTGVLARRAFIARAETVA
MQSEIGRTPLSVAILDIDNFKSVNDRYGHAAGDCALAHVASLISRSIRADDVVGRIGGEE
FALLLPHVTKEEAGRLVDRLRDIVATSGSCIPSRDVVPTLSAGVDAFGRGDTLATVMARA
DAALYAAKANGRNCVVVVPDTEVRPAEGWDRRTGAGKAAAG
>A0A8F7LH96|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MKMKSMSLLRQLLLSLSLALLGILAGTLALNLSGARSYLSEQLQSQSENAITALALSLSQ
PASQDPAMQELLMSALFDTGQFESVRMLSPEGVLVFERQQAASSAAAQVPGWFQRLMPVP
RAHSERTVSNGWNQLGRVAVTVDNQVAQQVLWHSSLKMTALIVGAGLSWACFVGLLLRWF
KRVLKDSVESEVMRIGADEADAAVQVLQVPELAGVATAIHDARSRVQQKDRAQRDRIESL
ELETNSDAITQLPNRKYFVNELKKALQRGEQTHGHVLLMRLRDLQALNSTRPREQVDEWL
HGIAQQLREQLRTRGLQQVQIARLNGSDFAVLFPQMTGMSVMQEVQQLRQLLQSLRLRLD
DGQWSRNAFSLTAYTDGDHIGDVLSRLDQGLMQAESAGHGEVEYAEPSVAGHAIHQPGEG
QWQTMLGQALQHADRLSVAVQAATYASLVDTRVLHEAGLELHEAGGKTMGAALFLPAAVR
LGLSAEYDLKAVQLGLQWLALQPKHHLVVRISQPSLEQGDFLERLSAQLQAKGWCEVLPQ
LTLELDAFALEVAPLKALQFCEVVTQAGAGVGLRRLDQAPKALVQLPKLQLQYVKLGGLF
AEQAMANMGGRHLLEAMMSTAQDQHASVLITDAVPANAADWLRFKGASLLVMAG
>A0A837M0E4|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. BIDMC107|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A8F7LHA9|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MRDPDFFKKNVEKVISRPAEYLGEEEFELVDGRTLIFISRVLTDQEKLSHGRVWFVRDVT
NERQSAKKLKSAHAAEEAQNLLLSNLLDLSPDGVIVVATDGAVLSWNRRFKEIWRISDDK
LANGSNTVFMHILDQTLHPASFAGEINRLYADSGCSVDGQELHMMDGRILVWYSRGLVTE
IGNVRGRAWFFRDVTSQRLMLRDLRESREWEKGVLESTSQAIITTDRNRIVRIFNPAAEK
LLGYSAEEVIGQIDPIAFHDMKEVEQRRKALEKKLSKLINLDELLTHSAKQAPSVFQEWT
YITKYGKRLPVELCVSQLYDAEGDLLGYVSVATDISERKAYERRLLELAWTDPLTGIWNR
RRFYDVVNKEIHASKRRLEPLSFMLIDIDHFKRINDTYEYDAGDAVLKFVAHKLSKLVRA
GDVYCRWGGEEFAILLINTDETTALEVAERICSSFRSLSIKHGKISLEITASIGVSVIID
GDINQTIKRADEGLYKAKNTGRNKVIVN
>A0A2T8R8L7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,12:i:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A174D4Y1|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MYNKNKKIKHKTLKICCLLIGMIVIAVFLEAGILCIVNSKNVYKTSKVLLDQTIEIVEKN
EQSEVGTVVADIPVYKGIALYVADKETGRIYGATDVSKIGVKLDDMGLRKQRKTVAKEKI
ASGIIRVDGKKNYYILKKTQKYIVGVTYWIAVDNKSNLIAILIMVVYLSIAAIGILFMVL
RLSKVKKKNKEQSVMISSISEMSNIDKMTGCFNRKAYDEDISEIRMDSQFIYVSMDVNGL
KIINDRQGHAAGDELICVAASCMKTRFDRYGKVYRMGGDEFAAILFVEREQFEWIRRQFD
GDIKYWSCNRIKELSISYGYVSSSECQWGSMKEISDVADIRMYEEKAMYYKKNGVDRQGQ
PASYVALYRLYTQILRINLEKDCYKILNWEETKNKKKQDSIGALSEWFHNFEDIRLIHSD
DLVKYLKKTKIEYLKKQFANKKKFVTITYRRKEGDGYKRITLEIIPEDENSQNTYEGFLY
VKE
>A0A0Q0HBK5|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MPKINIDSSYGVIIIQDMNAVHVDERYAQIYGYNSAKELLTSIDSFLDLLPAENHQIATQ
NYHDIVNGTLYPRGHTFVNIDRNGREFTVFSVDHLIEWQGRPALQVTVIDLSVLVEANKR
IREKDLMYKRLITRSGQGIMVHREFKPLMVNQACVKHLHADSIEQVMSLSSLLTLIPKTV
QQQAKQHYQDIVNGVAVGSNSVVENICFDGINRFFNIYDNLIEWDGEPAVQVVMEDVTEK
VQLEKELAFKASHDGLTHLLNRSAVQEWLQKHIEISDQLTCVLLDIDNFKLVNDTHGHHN
GDLVIQALAEIIRDAFADHSGAVGRWGGEEFIAFLPSANQQAALQTAEVIRSRFAERHFN
DSTHSFSVSVSIGLAESSDCCMMNDVESLIKLTDKRLYIAKSQGKNTICSEG
>A0A0Q0PD13|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MDYAIASQPYPEQNWGKSAPYTAGKDHNSDNNLMEILQQMHASLEPRTVFASYGKSLGQL
LPIQGVQLNHQLKLNWGRCHGLNQQRVISGFGEPYSIKYYLSSPLTPDQLIQLNEIEKLF
CQPFLNATKYSQMSNQAMFDALTGLGNRYYYRQSIKSALARANRNQGDISLVVLDLDNFK
SVNDQHGHKLGDTILSSFAELINDAIRNTDQAFRIGGDEFIIIAQGNALEMTPLCQRIIN
TMESHPLMSTFQVKCSLGVASSSGAQTQDKLYESADMALYEAKDAGRNCFRICND
>A0A701ZGQ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLNLTAATMTH
SLEAAMVFSDNAAVAETLATLERQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARNSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLHGVHSEYEVQRICAALSLAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A743V8I9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDVRAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITITLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A622U043|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLTRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDSAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEIVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5U0R7U0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTLKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A704QVR6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYRAKHRRTERSLN
>A0A746TR50|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVTSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1V5F8P9|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MEETELPCPFCNAHSTRPIALPDGLWSACCADCGARGPIAPDARTALARWEQATRDGELL
RTVIDESPDIILLKDWDGRFLLGNAALARLYDTTPEQLVGKDDGAFNPNREQVDFYLENV
RAVMRGGRTQIVEESSTNAETGEVHYFHSIKKPLRGPAGEPRILVIAHDITDLRRAYRVI
EERERSYAYAMEAAGEGIWDWDIDAGTVTHNRRWCELLGYAADTLVHPIAAFADRLHPDD
RDEVMGLLDRALAGVGSYEHEHRMRRPDGSVLWVLDRGRVVERAPDGRPLRMAGTVTDVS
PRKHNEFVLALATDALAHANAELERKVAERTADLARANEALARLARRDALTGLPNRLAVD
ERLHEESRRQPGPCGTGCAVLMIDIDSFKPINDTYGHATGDAVLALVAGLLAATVREADF
VSRYGGEEFLVLLPDTALEGARTVAEKLRTVVAETAHPVAGRITISIGLAMAAPGTGELA
TVVAQADAALYEAKRSGRNRLVIAPPPTAV
>A0A173SBI4|diguanylate cyclase|EC 2.7.7.65|Coprococcus comes|TrEMBL
MKKLSRHELMQYGTAIISFLIVMTFTLLIFFWFVQQSVDKSVQNVLQKNTLQQKDHLELV
LEKEYEFLESPAAYFGTTSDLFSNDNLQLLAELASSSSYHRLMLFSTDGIGHSSDGKKTD
ASSRDYFQKTLEGRRVISSPLSSSVDNETLVVLTVPVYDKDQNIIGVFGGSIDVTELTTM
LFEDLYSGSGYSFITDPDGNIISIESTHNEIRKNFFTSSSDWVFQTSEDGATLQEDFKQG
HANCRKIISDLSYARYISYQPLKYNGWMLCYIIPAVDARQPFAFINNFEIILFAFFICIV
LLLIFALWKINQKNQTSLLRQAHTDALTGLLNKVYAEHTISEWLREKDFEDLQALMMIDM
DYFKQINDTYGHATGDQVLKIFAGFLKEQFRATDIIGRVGGDEFMILMKNVRLDYSIHLH
LQKLYTNLQNIDIPELNDQKLSCSIGCAVAPTDAESFSQLYRLADHALYTAKHNGRGRFV
IYHDIKNQQETVLS
>A0A379Q668|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERVLLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A379QRE8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MTTPSWRSLRIKKYQFSLRLFLFLNAVSALFTLVFPLYQINVFCTPMIGILVLSVLLLIW
HGKYGQKRLNLPLISILFGGLWAAHIALKYPALGHYDFSFLLISLLSVLFIGSIAFAANI
VAFTLHSLPSVVVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKRYDNFAQQLMFKLLA
ERETLNDLSMLDPLTGLYNRRGLQSRLDTLQALGSHEHYVLLLDIDHFKAYNDHYGHMMG
DQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTAAEPRQARATAERIRQEVYDLKIPHM
FNESVATNVTVSIGIAPLTDRNIGDAIEKADKALYEAKHLGRNHILVSDDVRAL
>A0A702EF73|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFNKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLTFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLTRLARSSAMLTLETMYV
SRSGFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKK
VTASLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDSHLRLLADSVPEQQ
IANTLNDRERAILAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGS
ISIALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLVKRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICASDATQEREKK
>A0A6L5BSQ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas frederiksbergensis|TrEMBL
MAKTGGKGLSLARRLYTSRTLGLALGLMCVSAAMYPLDPAPWVWVVMLFNALVWPHLAYQ
WARRATLPYHAEHRNLLVDAFLGGFWVVAMQFNPLPSATTISMMAMNNVAIGGLRFLLAG
TVAQILGVGVGLLVFSPAFIPHTSPLQLYACLPLLCLYPLALGWICFRQAITLGRQKCEL
LALSRTDSLTGLLNHGAWKDQLEVEFQRCQRQNRGGAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKMLKQNLRAADVAGRYGGDEFCVILPDLPLNSAAAAMDALRDRFATLGYEQNPA
LKVSLSIGLAAFNPAHTDATLWLNDADQALYEAKTTGRNRVICCSDDKPRRELLDSV
>A0A1V5FE63|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium ADurb.BinA305|TrEMBL
MIAALSRYSLRRQMLLVLGLPSVVFVLCIAALFAYQSSRALDQALLERGRAMVRFLAPAA
EYVLVSGNREALGALMARVQVQPDVVGVGFYDAGGDALATLGEGVSPRLAAPSRAEGDEI
RVDLADGAIGFEAPVVAVPATVDDYAEDSSSKTAPVVGHVRVVLGTARLDAEKRGVFLTV
SLLVLGVLATAMAIAVRLAGSVGEPVAALVDAVGRMADGDLAARVPARARNGELKALEAG
FNAMAEAIAENQRTLQARIDEATVQLAWQARHDPLTGLANRRAFEERIEQAVRAHRRSGD
QITLFYIDLDHFKVVNDSCGHAAGDRLLSELGALLKGRLRSEDEVFRIGGDEFAAILRGC
GREDARRIAEGLCAAIAAHAFESDGRAFRVGASIGLARMDPDLQEADALMIAADQACYAA
KHGGRGHVVEYPLPFVAPGSARPG
>A0A1S8NIW8|diguanylate cyclase|EC 2.7.7.65|Clostridium saccharobutylicum|TrEMBL
MRDYEKMYNSLKTEYETYQMFCERHIQELNEKNIKLEKKIDSLYNIIEISKYINTFFTND
NLISLINDMIIGILGVTYSTIFLIENNELIIKATNIEGMHINLISREMAYINKEQEFIIN
SRDPLKQIGEEKTDIRSIMGVPIKLRDKFIGYILVEQNIYNFMTVELKVFLKTIANQIAI
SIENSSLYRELEKITQVDSLLGIYNRKYFFEFLEKKLCKENKFAIVMIDIDDFKKVNDTY
GHQFGDKILINTANVVSNWLDKDDIIARYGGEELIVYISDFNNEYSVYDKVEVIRRSVEQ
SKVILNGQEKSVTASFGISFFPLDGSDINDLIKIADDLLYKSKKSGKNKVLSTHILK
>A0A663B767|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae subsp. similipneumoniae|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVVKPSPETLEQYQQLQRSDKSIELRLARLKDNGANREELALLHDGLQIAAELQD
EQQAALAHVANGDAPAAIAILYGKAYETELERMQTQIDRFRQMLENRAAVAIDPATDRSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPQFTQVDE
IGDMAQAIRIFRENGLARQQLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAELFAP
NIAPTIPGKLYILDTDPWQMRCVAQWLAPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPEAHAGQSLCVPLIAQGEAIGLLTFQNVTASDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKAINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAEAHQCASEIYTQVHNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTG
>A0A0L6ZBE4|diguanylate cyclase|EC 2.7.7.65|Clostridium homopropionicum DSM 5847|TrEMBL
MEITKEKTNCKVLIVILLLIMSLYISLRNYILFHFILEIFCVVIASSIAILGFSSYSSKS
NSLVNNIGIAYLSVAIIDFFHVLSYKGVNIICSGANIPTQLWILVRYVESISFLIAFIWL
NKRINKSRIAIVYFVFTVASLYSIFFTSYFPDCYLDGIGLTKFKIISEYVIIAINVINIF
LLYKNKQYFETNIVKLFAQSFIFAIIGEAYFTLYFDVYGIFNALGHVFKAISYVFICYAI
FFENIKAPFEKALSNYKEELQKNLNLSLNMCIDFMTGLYNRMYLDSVINNIFVSNYEKTI
LIVFDMDNLKIINDKFGHVKGDKAILQTVNILKNNFDKKNILIRLGGDEFLSIVIGSDEE
EIKARLASIDEDLMNRGNELKIPLSISYGIAKYEGKIDKDIFLKLFDEADEEMYKQKAMR
KKHNSFIIS
>A0A238LGG2|diguanylate cyclase|EC 2.7.7.65|Flavimaricola marinus|TrEMBL
MDVEEKYDRLLARNRRQAWIWSAVVIVFAMALASALTFVFYPAELVPFIVWRTPWIALLV
ATPLVFLYSKLLLRNFELAMTLKRLVERDRLTDVATRDYFFARMDAAPRLCGVCLMIDID
HFKSVNDNHGHILGDAVIREVASVLDAECRSEDIVCRYGGEEFVIFLNGLGPAQGWEAAE
RMRRRVAQAPLRIDDTALQVTLSVGAALKHGNTDIMAAISAADASLYRAKAAGRNRTVTT
WHPQPESLRPVAGAASS
>A0A069RKS4|diguanylate cyclase|EC 2.7.7.65|Peptoclostridium litorale DSM 5388|TrEMBL
MSMKKISLAACFAAIIFLIITTVCIRGMSDGNKPVVKNGQADLSSWDFDEKGGVRLSGEW
EFYWEKLLYSDDFKIKPSHTRVSYIDVPSIWNGHVVNGKNVGGEGFATYIASIKLPEGME
TVYLKAYDMSSAYRIYADGTLIGKNGDVSADRDMAHPEFNPQIVKFNRENEWVEIIVQVS
NYSHYKGGFWESIIIGNEKSVEAMNGKSLMANFFVMGFIVSMAIYHMVIASLIRKEKAFL
FFSVFCILMSIRIFITGERCIVDLFENTNWETLQKIEYLSFYMMLPVFIRFIDYLFECKF
SRAFLKTVYAFSFIFSIIVLVFPAKAYTRTLSAYHVLIIISGIYVIRAIVSAVRDNINGA
QEFSVGFFGFFAAVLVEIVSVQKVLGYQGTLFWGMIFFILMISIAISKQFSAAVIDTEKL
ALEKEKMVEKVNELNEKLKRRNSDLVNRVTRDGLSGLYNHRHIHEKLAEKAIKANMYGSC
LSIGMFDIDRFKDVNDNYGHQFGDKVIVEVARILSENTRNSDAVGRYGGEEFIVIFDGAD
ENVSFEVSERLRIEVEKQIVKNLGVRVTISGGVTELENEECPTNAIRRADELLYRAKRNG
RNRIERSMTSKPAQIP
>A0A3P3XNS4|diguanylate cyclase|EC 2.7.7.65|uncultured spirochete|TrEMBL
MKIDISTINALFTDSSLSGFFAETDLFYIDFQSGTARSCYTLRSLGYEDNDLLNITSPFS
VQEADKERADRLIHRLIANEADSVIDAFRVASKDGSSYHWLRFSTRVVSRDAEGRPEAII
GHVLDVDDLITSQEEIRDRLVEIDAMRELITAINKSLDFEETFLRIIEQLHRIIPFDRAS
AQSLENDRLTVVAGFGYREGELEGLTFPAHGIENPSVRALQEHKIVICNNVPEEFPGFIR
PNNDFITLSWLGIPLIYEKKVIGLLALDNQALNAYNDQHVRIVSSLADYIAIALEHARKH
QLVTYQAMTDRLSGLANRYGLETQGMEIFQKSIEQDQSIGVLMIDIDHFKQVNDTYGHAY
GDIVLRSITQAIREQIRSRDYAVRYGGEEFVVLLPGLSAREALIVAERLRIRISQTVIEK
ERRLPTVSIGIYAAVPGPLDILHEFIRRADLALYTAKEAGRNRSRVWSTSPEFYVNE
>A0A1D8I674|diguanylate cyclase|EC 2.7.7.65|Achromobacter ruhlandii|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNAQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHQGMKGWLRGLLCVREQGDIAALMAIQKKVGEVHARVH
IPIHLVMAGARILKNEIAQRLRASDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPSLLLVGPESLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAINDQHGH
AGGDQVLRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGREAALAVAEKLGAEIRRHAF
SIPEAGGLRITTSIGVATFDGHPDYAYLIDRADKALYQAKQSGRDRSVAA
>A0A2S0XDF0|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MGHVTRLRDIKSRFRLFALLWPFIAVVLVQAIIAGASLYTLSAVRAYVAGESAWSKGQRD
AIYSLAMYANTGDARFHDRFQQAIAVPLADREARLAMAQPVPDYDAAFDSFLRAGNHPED
IPGMIWLFRNFRDVSYLSNAVQRWIDADPKILEVAALGEAMHQDISNNRASPEMRAEWSR
KIQSLNGETAPLADAFSQSLGRGSRAITTLLLSVNVITAALLILLAMRRTGNLLQQRQAF
EDALNAERERAQITLASIGQAVVATDAEGRLDYMNEAAERLLDWRGTDARGKPLDQLFRL
MNEEADKEDRSFMARVLSGEAIDGSGVPQQLVRPDLSSVAISLVGAPLYVEQRVVGAVLV
FHDRTKEQEFLAQLSWQARHDTLTSLANRFEFETRLSASLEGLAKRPSTHALMYLDLDQF
KIVNDTCGHAAGDELLRKVSTALRQNLRSGDLLARLGGDEFGVLMENCPAELAAGTGERL
RKAVEELHFVWAGRAFSTSVSIGVVGLSDASMTLEETLRSVDIACYMAKDKGRNRIQLQQ
IGDLELEHRLGEMAWVQRLREALEQNRFRIYAQEIVPLQADETTGAHIELLIRLADADNN
MIPPGAFIPAAERYGLMPLIDRWMVRSAFERLAVHKRTQPDNPIAICAINLSGASFGDDS
FVSYVLEQFVRSGVAPSTICFEITETSAIADLDSAARFIKSLQAHGCRFSLDDFGSGMSS
FSYLKALPVDYLKIDGGFVKDMLVDRIDRAMVEMIQHIGEVTGKRTIAEFVENDDIAIAL
RDIGVDYAQGYGIARPQPFDDGFATGKRRRLGAASGATPGLPLAS
>A0A290HEJ7|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MNKQLQELTDLTIKEILNLEIVLPEIYRDIFYTKAKELGIKVSDIDKEAALIYALQKIQY
IQNETERSTSALKENVVNARIAIENKDNMALQFIENNMIELEFKIASLQEELYVDELTRL
YNRRWLFEKFLKDDHFISNGLLAFIDINAFKAVNDKFGHLVGDKVLHVMGKVLKKVHNTT
AIRFAGDEFLILHNSENEEEIHKILHTVNLNLKKTPFKHNQEIFYIDFSFGVAPFKAKDS
FKSVLETADLKMYDYKKSFK
>A0A290HQX6|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. JPD-1|TrEMBL
MATTINEIIKDALELIKAEHLNLTPDNYAKVFCKVAKQKGVIVEDCQKVDKYTKKLDPTI
ATDMKRFSISNVDELLAFLVAKLNRANEGDALKMVNTLAILTKRVLQAITLLHDAKATSL
ANASLERLDFHQNLQSIELVKEKWFDFISNYDDSYLKKLDSFGHVSKDDLEAMVRDLIKI
MSKDTSSELYSTLVPLIIASLAPSIASGMNDELASIGNELRNSPDALGTPALQKELKGLI
SKRIELDKAEVQKKVSALDKILDEINKKILELIQNSNVSHEQVKVIKADLQSINFEHDSF
ENVHVKLLNIASSLESETKSLSEKMTSNQETITKLQNRVSKLESALLVAKQEVKEDYLTH
VATKRALANELGRVEDAFMRYKVDYTICFIDIDHFKMVNDTYGHEAGDVILSTLGKILRK
YVRQVDFVGRYGGEEFLVILPSIDLAQAIHFADKIRAIVEQFKFLYKNERINVTVSCGVA
QRSLEKSKEETIGSADSFLYKAKEAGRNQVLPVL
>A0A3A5K3B9|diguanylate cyclase|EC 2.7.7.65|Buttiauxella izardii|TrEMBL
MIKQSTKELIAMPSFVLPVGLGFLSFIFTLYSLELSLVGTVLAPLWFPTALMMVALFRNS
FRQWPMVIVMCALGSLCASALLLPVSEINLGYTAINIIEALVGASLMRRMLPQDNPLQNL
NNWVRLVICSAVIPPVIGGVLAVWLAGPAGGPVAKTFFVWMLSETIGTLALVPTALLFKP
HYLLRHKNPKLLIETVFTFVITLALSYLALRYMPWPFTFIIVFLMWSAIRLPRLEAFIIF
LGTLMVVSLMMATHNTVNMDPHTAVMNNAPWLPFLMILLPANVMTMVMYSFREERKHITE
SEARFRNAMEYSAIGMALVSTDGQWLQVNKSLSKFLGYTAEQLRSLTFQQITHPEDLHAD
LQQLNMLVSGSINSYSMEKRYYTSKGDVVWALLAVSIVRDIDGTPLYLIAQIEDINDLKH
TEWVNKRLMERITLANEAGGIGIWEWDLGTDVISWDKRMFDLYEIPAHLKPTYALWLERI
VADDAPAAEKTVRDALKARVPFKMEYRIHVKEGIRHIRSLANRVLNKNGDVERLLGINMD
MTEVKQLNEALYQEKERLHITLDSIGEAVICTDVEMNITFMNPIAEKMSGWPQQQAIGQH
ILAILHITFGDNGPVMENIHSGDYSRTTIEHDVVLHCRNGGSYDIHYSITPLTTLDGQSI
GSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFENHLKRLLQSAGENRQRHALVFI
DLDRFKAVNDTAGHAAGDALLRELASLMLSMLRTGDFLARLGGDEFGLLLPDCSSDNARH
ISERIIQSINDYHFTWNGRLHRIGASAGITQIDADNRLASEVLSQADIACYASKNGGRGR
VTVFESSQHDIRKEGQNIPLDEQKCIIHENPILMIARGVAPPRVPESTSFYLLSLRFWGN
DGVVIDETMFRATIADAELHCALDLRIFNEFFSKFAQSVTNKGFGVTLALSSHGLANDKV
VDELLALLEQSSLPARLLHLMVHCEVLQTENAKIDRNLQRLHDSGCQLILSHVGRDLDIF
KRVSRQCFSYIIVDEELIQNVHCNLMDEMMVTIIHGHAQRQTLQTISGPADIPMVMDTLS
GIGVDLIFGEAVTQPLPLEMLLNSSYFAIN
>V6EWN1|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MIRTPQAASPQGNRIDLQSVMESVVRITEQRSRENLEHCLVTTLLELTSLHRVAISRPLM
RPDGLHVETVAVAELGKGLVNSNEVTPLDQDHLVAQAWALGEEARMAGADGLVRLCLPIS
GQGEEVSAFLSIETSTNPDTVLDLVRGFAAIYRNFLAILREAERDTLTGLKNRKTFDEKI
GRIIAQSQTLAQIVPVERRQHEDGEQHWLGMLDIDHFKRVNDTFGHVFGDEVLLLFSALM
RKVFRSDDLLFRFGGEEFVVVLAPTSALHAQQAFERFRTAVEGFAFPQVGRVTVSIGFVA
IKHGDIASAVIGQADEALYWAKRNGRNQVCLYEDLVRAGHLKAPTEEGEMELF
>A0A379XUU9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. indica|TrEMBL
MIGILVLSVLLLIWHGKYRQKRINLPFISILFGGLWAAHIALKYPALGHYDFSFLLISLL
SVLFIGSIAFAANIVAFTLHSLPSVAVCLWLNGNEQGLRILYLLALPMVGIAIQHVIQKR
YDNFAQQLMFKLLAEREALNGLSMLDPLTGLYNRRGLQNRLDTLQALGSHEHYVLLLDID
HFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTAAEPQQARATAE
RIRQEVYDLKIPHMFNESVATNVTVSIGIAPLTDRNIVDAIEKADKALYEAKHLGRNHIL
VSDDVRAL
>A0A5P9B355|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MINYQTLDFKKALLGLTALFLLVLSLLLVDSAEESDALYWIENQRVSQSLEELTQIINAL
EYNITALYPLHGDTYAFSHTRKIDGETCYFSSEEQSQPRFDFMFSGPIEMCDPRSQLNVE
ASKRLFIAPTMAYFANTIDTISAIYFISKEKFIISSPSDFASYIQGDTFDSVVNSRPYWI
NTIRFGLTQKKDRVVYTGQYDDYLTGKKVVTLTKGIYVDGEFKGVLGVDGYVSNLVSNPK
HGYEISSTLGVNKYGFMDFTHSHPLYVDGLHTQLYLNIEEKKREHILHVLEMDRLQLSLL
LGLFITSALVLWRICTKQEHQRLSELAMRDPMTGLLNRRGFEARLMAQDEEPIIGIGVFD
IDDFKAVNDKYGHKVGDEVICHVAHLMTSSVRQRDIVARFGGEEFVVAITGESSELLTSI
FERIQNDISLQGYRCSDGDRISVSVSGGATLYSLYKFDSLAHLWQNQSIRASDEQLYQAK
ISGKNQVCIQVF
>A0A5P9BFV0|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MNERTFRQLNVFLAVTCLAITAFSLISFHIGMDKSFTITPERFEFKVNTDQDYGGGTRGY
VTQENDSITLHCNFKRDYRSPFCEVEFVISEDGQGVDLSKYDSVTINMDYEGQENPRFRF
YARNHNDAYSVIEDPISNKFNRFDFSLNDKENIDLKYFNVPLWWVDFYKHPIANSGVDIT
NTVSVELGLGSSTLEGLHQLTVHSIVFHGKVISHLTLIRVLIGIWVAFAIYYVAGSMYQI
HRCRKVSDAKAIRLKREIAELRVKATTDPLTGARNRTQALDSFYDFERLIQQGKAIHVAL
FDLDHFKLVNDTHGHDIGDSVLRDFSDLSEQVFNENYLMYRWGGEEFLLVCLEQTTSQCN
DKISEFMDAMARNLWPQSLEITASIGLTQLERKESMRTAIKRADTALYQAKNQGRNRVVY
L
>A0A846N4U4|diguanylate cyclase|EC 2.7.7.65|Rhizomicrobium palustre|TrEMBL
MTARVLVVDDILSNVKLLEAKLTSEYFEVVTAFSGMECLDKIEGADPDIVLLDVMMPGMD
GFEVCRRIKANPKTAHIPVVMVTALDQPSDRVAGLDAGADDFLTKPVDDAALFARVRSLV
RLKMMTDELRMREATGQGMGLVDPATTFSESISAGRILMIEDRPDSAAWFSSALRKENDV
ACVDTFEEALVRVRGGDFDLVIVSLGMRGFDGLRLCSQLRSLPEGRHVPILVVVSDGDRR
KLNQALEMGVNDYLTRPVDTNELVARVRTQLRKKRYADRLRHNVQLSLEAAITDQLTGLH
NRRYMARHLDNLIEQSHRTAKPLAFLIMDIDYFKKVNDSYGHDIGDEVLQEFARRISANV
RGCDLACRYGGEEFVVVMPDTDVPFAYAIAERLRKTVESTPVMVSRDPHKLGITISIGIA
QSAGKNDTAEALLHRADQALYSAKRTGRNRVVADAA
>A0A5P9BFU2|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MSSSFVTSSLFRFSFPLLILCILLVGMNNIILIAESNRGFANNLPYILLSVAGILCFTFK
QGRMAMVSVTMLIAYIVIQTRLQTPINTGTTLLELSLLATLLPVSCLLVYAFPNTALSVR
TTTFYLAAIALFIAWSQLIISHFYDGGFDSWSEGILFTFPALSKIPFVLVMYSFCLSGLT
AILVLMYNRPIDVVVYSSIIMASATFVFFDVQYISSTLFSLSGILIIIYMMSASHALAFN
DQLTNIPGRHALESDMKHLGRKFSLAMLDIDHFKSFNDTYGHDIGDEVLKLVASRMKLTS
GRPRIYRYGGEEFTIIYKRKQAKHVVTHLNELIKDIEAYDITIRDNQARPNCDETGSKNR
GRGPAKSKIVNVTVSIGLADSKTTKKPEEVMKLADNALYKAKKAGRNRLSISKE
>A0A5P9BC28|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF190c|TrEMBL
MRSYPGFQNQRFKTYFDNEIYLPYVNFIYLPITIFLAFIITDFIHFGDQCIMPIVLRVIL
SALMAGAAYYCINNRPNILQQLESLLLITSALFLVVVGRIAIGFGNYDYQGGVILVMIYL
GTFSRLSARYSLFTLTCILASYLIGLSPLLYAAEPAHELEIISIYLATYVLVAAASLRRD
LEVHKRFSQSEQLRKQAIQLRKQSNLFEALSYQDALTGCYNRLYLHQVIEPNINRNQSMT
TIMIDIDHFKSVNDTYGHQTGDMVIKELAKAIKAKLPVKSNLFRYGGEEFLIIAQGLNST
QAQQLSDSLLTSPSKLSLDVTVSVGVKHIDRAVGSVEQLIEDADRALYQSKKNGRNCISW
CTVSYPNVETVAV
>A0A554XJZ3|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MARLLRKTFRHDDRIYRFGGEEFVVLMRAADPEAARAALERLRLQVQDYPFPQVGRITVS
VGYTRIREHDTPSDAFERADRALYLAKSQGRNQVCSYETDVNPAEPSAASRGAEGDIELF
>A0A6V8LUT7|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MNAWILAAEAFAVYGLVLWSHSLRHRYGLAFFYALLGSLTAIMSWVTDAGVAVQLGDTTY
LVGSTVFYTSLLLGVFVVYVFDGPRATRVAILTVVGVSALVPLISVVLHLQTKISSTVPL
ALVPIPSLRVNMASVLTTLGDLLFLAISWEFLHDKKRALPLAAKAFLTLLGVMWLDVALF
NTAAFLGSGNYLSIMTGTLTSRLVICAFAAPILWAYLSWQNAITGVEMPHRPVFAILQEL
SEVRVELQTAREEIKRRMQVEAALLKSERRYRQLILNASEPIAVVHSGLYALHNARLLEL
TGLSETDARTATFEDFVHPAQRAQVRQVLDQALARHGLSKSLEFKAVRGSGDLIDVQANI
VGIDWDGDGAVLVFLHDVTEQRRAEDRLRADATMDQLTGVLNRRGFIESAEAKAERLQRE
RRGYTVLYLDVDRFKEVNDAHGHLTGDKVLREVARAARDQIREGDVLGRVGGDEFAVLLA
GSCSREARSVGQRIVERIPGACREGEAACSVTVSLGVASLEPGMEESLHQVLDRADKAML
AAKRDGRDRVRVHGDAPAPDKDSGS
>A0A7L6Y9P6|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB21-C01|TrEMBL
MPHETTIENWGWLKMLARRFGPGHVVNLCFLIVMIFSTLLTWREVVVLEEAYISSQRNHL
ENVANGLDKQLQYNVDKLLFLRNGMQEALAMPLDFPALRDAVSRFEQQRDSRFWQLELDK
RRTLPLNGVSDSFVNQTHILSRDSDTLDNELTAALEVGYLLRLAQTRSSLTQQAMYVSRA
GFYVSTQPSALSSEITARYYDYVIQPWFKEQSQRQNRMRGVRWYTGQTTQLRDELQRVTV
SVPLDNGQYWYGVLAMTIPVSSVERFMEDAIDKDVEGEYQLYDSKLKMLAASTPALRNIN
TFDAREQATLAHEIEQDTEGGLRMGSRYISWQRLDHFDGVLVRVHTLSEGVQGDFGSISI
ALALLWALFTSMLIISWIVIRHMVSNMFVLQSSLQWQAWHDTLTRLYNRGALFEKARQLV
QRCRAQKQSLSVIQIDLDHFKSINDRFGHQAGDRVLAHAASLISGTLRANDVAGRVGGEE
FCVVLPDTTLAQAERIAERIRLRLNEKELLIAKSTTLRISASLGVSGTQETHEYDFEQLQ
SLADRRLYLAKQAGRNRVCASERG
>A0A6V8LPB0|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MDKASPLTVWVPLSVWNALPPSTRRHLRDWELTQRVLVLDSDKKGPDVEEILELGFLTAL
TPPVTDNKVRDAVFRAKEVRGLYDDIFGMTREIMLERELLARKTDQIIFLNTVLTRASQS
LEPGRILSDAREDLSLLFPVHGLQGIFWQPDDEGRLEAELFLAPCLDPHGRQRWVEHLMS
HGTRLAGGMLDAFTVEYLIQSSPEDCLADPTPQNTLLLPLKVAGSAFGCLAISKDKDLRL
GRDQVTSLNAAANHLALALRNAMLFRDVKAKADHDGLTRIHNRQSFDERLADELKRHQRY
RHNLSLLLFDLDHFKAINDTYGHQAGDMVLRDVGAILEESCRDTDFAARYGGEEFVIILP
QTSEEQAWVLAERIRRKVEHKGFQFSDKTFKVTASIGVATLTPGSLDRREDLIHKADQAL
YLAKSGGRNMVCVSQGREQMKAAALARPA
>A0A6V8LPQ3|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MPLDPAPSSPAPGVRARLGVTSRFGLAFAVVLAAFVLGGAVNFASMMIIHDAEADIQTSM
DVRQKVFDMDAGLEKARRLYRDFLLTYQEVGFAKAQETYGQPAFAATARVIAVNEELRNL
MPAFVAGESLRRRNMDITLYLSIAKRFSTVMLESMALLTALADPENGLETRLDQRMAELK
AVFASNPNLSFLVREAELDEKRYRITRQRPSMQLAFNKLSRIRLALGEMDSMPMQRKLEA
IHLVDDYATLASRVLDADVEVRSKINDMSLQAKTIDPISQELRKISQDEVTRSRERIERV
SGAALWINLGMTLLGIACAAGAAAYVSRGVTWRILAITRGAERVRAGNLEVTVDPGGRDE
LGALAEAFNQMTGRIRELVDHLEETLRGKDRELDLGRRALDAKQRALLQLSPADRLTGLC
NRRRLEHSLRAELRRHKRFHSAPFSVILLDVDLFKTVNDRFGQQVGDLVLVRIADALEDL
ARETDTVGRWGGEEFLLVCPETDANVAAKQAQRLREAIGEIEFSLVGHVTASFGVTACVP
DDDENGESLLRRAEAALYRAKLNGRNRIEICI
>A0A6V8LYP4|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MKKRFGNRLRNLRQQAGLTQVQLAERVGLSDRYLGRVERGMVSPSFECIERMAQALGVDP
AELFLTAGQMLAHAPVMGSTLDDVLQERAAILRALPGLTVKFVDTDLRILWVHTSDPESP
MARGLDCTGQRCHEAFHDRQEACPGCLVPQAMARLEPVEGEVASPAGRSFLIRCTPVMGG
DGTLRGALHLSLDITARKAVEEALSATRRRLEHMLSSLPVVLYALDAGADFAQTSVSDNV
QEVLGHHPSDFLETPGFWRSLVHPADSQRLRQAIPNRLIEQNFLTLEYRVRHGAGGWRWV
RDSLRLQRGEDGKPREVFGAVLDITDSKASEIALRESEARYRTLFLDNCTVQLVTDVTTG
VILDANPAAEAFYGYPLSELRGMHIASINMLGPVKVMDVLREASASRQNLLRFRHRLSGG
ELRDVEARVTALEISGRPVIHSLIIDVTGLRTSEPVGGPGGD
>A0A653XEB1|diguanylate cyclase|EC 2.7.7.65|Massilia sp. 9I|TrEMBL
MRKHTETIVGELSTVWSCTSFGAPELSAYAAPVIAGETRRGVALLSLVALLFLLLAATVS
AVFNLGTGYTYTYSVLSALALHIYVSSARVEQLRALYLLAMLLLIVCGSALVLLAQRVGQ
LHTILLLSVAVLIMLVPVVPWGVREAAMTLGAIYLMFTASTWLSSYRFAALDLWVLQCLM
LIAAMISLALVGRALGLRKHDLALRFELERAQRELTELANRDHLTGSWNRRHLEAAFAGV
VARHQAAGLPSWFGLFDIDRFKSINDSFGHATGDEVLRAVHAAFGQLSADEHLARLGGDE
FALLMCGDGVPERAARMLASVQDRMRVPLPIGAKVTVSLGLVRLPERACPAFDAAYPLAD
ELLYETKRAGGNGMRIGAAPEVAA
>A0A1H2PK13|diguanylate cyclase|EC 2.7.7.65|Chitinasiproducens palmae|TrEMBL
MILILYKRWPARQSRLDDGDARASANHPTKVVPGRATFPQAVVRWRRLPTLNGRACRGGV
RWRRPHSALTPPAPCAAPMPTSQFLSESQAAAEWRELIAQTRPAARAVLAAAADEQLPGL
ADLFYEHMLADPHASMFISNEQVRDRLHASLQRWLAAVLTAAADDMNGLIALQRMVGDVH
ARIGIPVNLVARATRRLKRALYDALIARMPPSDDRSSALIYVSQATDIALEVMTASYSRS
REQSAKTDEAYRLFSVMQNVGTERERQRAALLDWENAFVYRIAINAQLDELQKMAASDFG
LWFHHKGQPAFGDSREAQSVARLIVEIDEAMDAAMAAAAVPQSVEPMAARIALLNLVRDA
VGQLKYLLGALFEQIAELETGRDALTHLLNRRFIPTVLRREVVLAAQSRTTFSVLMVDID
HFKAINDQYGHDAGDLALQTVAALLVHNVRGSDYAFRYGGEEFLLVLVETTESQARTIAE
SLRKRVEQETISSKSGEGIKVTISIGLAMHTGHPDYERTISAADEALYRAKKNGRNRTEC
AF
>A0A1V5PSI4|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.Bin346|TrEMBL
MKHQFRITRRELILEDIFYSLTNLVKDAIIVADSSRKIVYWNKASERIFRYQASEILGKS
LSTVLLQDVLSFSVKSSPSPKEKFIEVIGRKKNGQKIPLEISRTYWESEKGHFFTLIIRD
VTIRKNAEEKLKYMSFHDNLTGLYNRSYFEEELQRLNTARQLPLSIIIGDIDGFKLVNDA
FGYKQGDELLKNLAKVLKDSCRSEDMLARWGGDEFVILLPKTDIKGIQEIISRIQKKSRE
VSSGGIPLNISLGFATKEKSTDNIDRVIKEAEDSMKQKKLIQSKKVSNEIIASIEKKLRE
RSRESGEAYERIKNLALTLGKALKLQKSDLDNLALLSDFHDIGKVTIKTRILTKKSKLAE
EEWQIMKMHPEIGYRIAKSSVQLAQIADAILAHHENWDGTGYPYKLKGNKIPVISRIVAI
VEAYDVMVCGRNYKKAVSKEQAIKELRLCSRKQFDPQFVSKFIEIMEQKEKNLSLFP
>A0A4P7CFL3|diguanylate cyclase|EC 2.7.7.65|Saccharomonospora xinjiangensis|TrEMBL
MLTYLALTVTTVSTLAAGSVAFRLRCQLRRDPLTGLGNRLALVTAFARARRRSPLVAVAL
GDMNGFKAINDTHGHRFGDRVLIEVAAILQRTACRRELVVRLHGDEFAVLIPCDTPDHAA
RRLDTYRAAVAALDEVDGQPITASMALGVITAPSESAELSALLASADDRMYGDKHAHNST
RKEQLECRSISPAKAS
>A0A7Z2J1S5|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNVLASWMLFSWGSVSFIYPSINVIEAAIGALFLRKWLPWYNPLQN
LNDWIRVAIGSALVPPLVGGILVSLLVPGPEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLHTDL
EQLEQLVNGDINTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEKVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSMMSLDEQWHMIKDNHLMIIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTYAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A653WEI7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 8Z|TrEMBL
MLKRFVLPLVFLLGLANLCQATPSITLSKASSGMPLNTQAELLEDTQGTLTIADIDSAEQ
QARFQPANGRASVGQSLHPWWIKLQLQREKDAPSRWVLEVGSVTLLDLQLYLPDGQGGWQ
LRQAGEHIAFRDNRDHPYRRMVFDLPSLDEQPLTLYLRTFDPAGNSFPLSIWQLDDLTQL
ATHENLGLGTIYGIIFALLLYNLFILIALRNQAYFWYVLTTAFALLFIISMTGHGAQYFW
PNHPVPVWLDRITLPSLWGLLVCRFTQTLLQTRLHVRWAHRLLNTACVIYLIAITLNLFE
QRYLAAWMITLLPLISIPAALGSAIVRWRQGFLPAQLYLYGYGLVLSSVIILLLRATGVL
QPAQWNAYAFPLAVAAESVLFSFALAYRIQMLKLERAEALQQADREKTARLAQLQTSTDE
LQAAVDARTAELAATNEQLRTRERELQHAAFHDPLTELPNRRYLIERCESALAHAERHEE
SAALLLIDLDHFKPINDRYGHAAGDVMLQAVGKRLREQVRAGDTVARLGGDEFAALIGGK
DAERQARDIAQRLLAALSEPVLFGSERLSVTISIGAALYPRHARNFTELYHTADLALYQV
KEQGRSGSRVHDDNDVPGVLTH
>A0A653INP6|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MAEFPHVPRLAALNVETAVVLGSALAASLAAVRFQAFERFCHLVRRFEYMQLDEVMIIAL
VLSLAFLYLFIVRDLQVRRYIREMELQRTRAVRAAHVDELTGLPNRRALTERLRSIRCGA
AADMTVLMLDLDGFKAVNDRHGHETGDDVLRCVADRLRHMSERWPGMLAARLGGDEFACV
IQPGISGDALERLASNIVQELTAPMPQCGGATIGVSVGIASNANASNVGVLLRRADDAMY
CAKRAGGSCFQMAQTLYSGSPLPSQALPA
>A0A376F433|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MMNDETYYNKKRIREEWNLTLSQDDPHRAGIQFARRVRLARAVGLAAMFFPVAGMLVTHF
LPGGWWLLLVGWSFVWPHFAWQLSCRAASPHQQEIFNLKIDAIIAGLWIGMMGMNALPTA
ALVMMVGMNMMGSGGCRLFIPGIALTLLSALVTLPLAGKVVIFNPDPIEWSLTLPVLMLY
PMLFAWLSHRTAVRLAEHKQRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRDHSTATI
LLIDIDHFKNINDTWGHDVGDEAIIAITRQLQRSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRLHERLEKLTLPCAPKEALRISVGVAPWGPQFGHYREWLKAADVALYRAKNAGR
GRTEVAA
>A0A4R8F6M2|diguanylate cyclase|EC 2.7.7.65|Buttiauxella sp. BIGb0552|TrEMBL
MKNIQPLNYDIIKNEWQLLINNTNAATHQTLMSLSDEEVRQLVDAYYQYMLQDEKAKLFL
STTQVEERLSASMNNWLRKVLGSSCEDLSELIAHQRKVGEVHARIGLPIDLVARGARKLK
YELFQLLLNKPQISAKEISDAIFFSGMAIDSAIEVMTIAFTPSHQKMMHDQEHFRLLTVY
DDMNVERERQLGALKDWENQFIYNIATELPFEERVLLSDSEFGLWFAHKGQHIFRQPDLI
KKIDSLIQKIDRVITTEFANESSGAFSRIHLLRMLRQDVEQVNMILSSIFEEIVKSENGK
DPMTKLLTRRFIPTIMGREIGLSISSGKPFTIALLDIDYFKKINDNYGHAVGDNTLKNIA
TWLHEYVRSSDYVFRYGGEEFMLLLVETTLSQAQVLTERLRNHIASQMIEVDVDTSFNVT
ISAGLVEFDNHPDYQRLINKADQMLYQAKNNGRNCIESYPFGMNNSL
>A0A4U8Q4D9|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MRSPESRCIMSTLIYSYAVPLTGLLFLLYLISINYLFSKEQNRLFKSAVIINLGLIVITS
LDYMFRWEANLSIWYLRRITSFLNFSCGPIIPMLLMRIFYKDKFKKIYYIPLFINAGICF
ISIFVNIVFYISTDNSYDRGILFFLPAATTLFYLMLMIFFPAQKYDQGKKTEQITIAAIM
ATIILSIFLEVNYGYYCLNYGFSALGIIIYYISQNINFFAVDSLTGAYNRQMFNLAVSKI
QSKQDCMLCLIDINNFKYINDTFGHEEGDKALVFFSEVIIKNMRKIATVYRTGGDEFMLM
AKKENETVLLDAIEKSIRELKERKISFAYGMTHYRAVNDIQDALREIDKKMYENKKRATE
L
>A0A738APD1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Abortusovis|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNS
>A0A1U9Z200|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MQSLIVTGGLAILAGSFVLAWFTGGRQRYLMLFAIALLTVDAAFIGMFLRPYVPDNIALP
FSNMAFIAAQLTFGESLLQRRGKSFGRTFIIGMFVLLSAVYVVLYLTSTIEIRTAGINIG
LIVIFVVTLKHIWIRRDDTIHDKLIFWTFITLGLMHTIRTAGVFFNQDIANPQSVFWGFL
QLYILLLAMILTLELLASHFVERLETANTLRDRDHLTGVLNRAGFERAVGAIYAGRTRVM
VSLVLIDIDEFKAINDALGHPVGDAVLRRVGAVLIDQSRAGDIVGRIGGDEFAILAIDLG
AEGAGALGERIRRRLDEDASAGQGRQLSARCSVGAATINIERGYETLYAAADAALYEAKR
LGRNRVVSGAADSGRDTEQGAGRVVPFVSERRRTDI
>A0A1M4NDW4|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. N3C|TrEMBL
MDSFITTSERFVSRELQIELDKYGNITYISFNCFDILGYTDKEMLNTNISKYLKYTYSDI
ASIKNFNTEIITKDGLKLYFDVHATPLLTDDNQEKLYLSLINITKYQELEAREKMFFNMC
ENSKDIICRLELVPEIKFSYLNPCAEKILGYSIEEHYKNPMLPFEIVHPDDYHIQMSKID
SKTDFSKMFEVRFKHKDGYYIWLQDYIIPIYDDNGQLIAVEAITRNVTDIKELEQRLEKI
GYTDKLTGLYNQNYFLKEMNSLNTTIDTSVGIILCDLDRLKYINDSHGHLIGNTLIKNTA
KVLKSVFSNEHVIARIGGDEFVIIIKGKSCFEVKQLYNELQKAINLFNENTDSIPIDISI
GLAYSETSISKMQSILYNADNNMYKNKKYKKQNY
>A0A822WKT9|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MSQNSFDALNAIKTPVWLISPVSEQIIFANVAAIQLTGNKTLNDLRKGSCSASAQTVLSM
YVPELKNDHDIVEIWTVSRGGQDVPISCRLSLTHVTPDGDVIVFEGISSHAPSGLKASRS
ATYQRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALSFYGYSHDEMCRKHTWEIN
TLGRGVMPIMTEIAALPGGHKPLNFIHRLADGTTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELENAALRDSMTGLLNRRQFYNVIDQTNLSHLSAQQQFSLLLVDTDHFKNIND
LFGHLKGDEVLIALSRTLEACSRQDDLVFRWGGEEFVILLPRTSLETALKIAESVRAAVA
HITLPGLPRFTVSIGVARHNPEESIDALFKRVDDALYRAKNDGRNKVLAA
>A0A3U0D017|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A554XG98|diguanylate cyclase|EC 2.7.7.65|Tepidimonas fonticaldi|TrEMBL
MEPLQPGLTADEAAACLRPVLDHFREGFVVKDAEGRYLYANAAAARMLGRLVQEVVGRRD
EDLLDATTAASLRAGDQAARLQSRPLYRDERLPGGDEGVIELQTLRYCAPGAADPAAAPV
CALWTDVTQVRRLQAQLRHALEQLELQQRQNEELRQELQDQPVRDPVSGVYNRHHFEEQL
RREIDLSLRENREFALVAIRIDRYGELLERLGAAAGERVLQALGRLLRGNTRVMDAPCRL
GEERFAVLLSGVGLATAHARMESVRRQCEAQMVLLEGSELRFTVSMGVASFPHTAQDRQA
LLAAAEAALARAGERGGNCTLPAPIALDPR
>A0A379WP52|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MKDNSARSSSALLFLDGDNFKYINDTWGHAAGDRVLIEVAKRLAEFGGSRYQTYRLGGDE
FAMVLYDVHSEYEVQRICAALSQAFNRPFELHNGQRITMTLSIGFALTWEHATAEKLQEL
ADRNMYQAKHRRAERSLN
>A0A3T7NNC2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A7X4NTR4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVVPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHERFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A6L3XXR0|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
METYLQTVKEEWVKLINETDPDVHRLATELARDNAMPLVAEFYRVVLADPSAAEFLTTEQ
VERQLQEALRRWLIDVLSCRVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PVITTSAHSPEVKLHIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTAALLSWEMVLLYKITLNSSIGNSLPLGQSEFGLWFSHKGRHYFSGIAEAGHISR
LIQEFDDLFNEVRLAGQGLSDKAQRDKFLQRMRNTLSQIITLLRELFDEVSRHEVGVDVL
PRLLNRRFLPTIFKREILHATR
>A0A8H9RSX2|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQSIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKVINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEFICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A8B6A6B3|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MVSDTQGVRVQHNTFVVKQSFLQWLHKRSNPRLVVNLCFIVVLIFSTLLTWREVVVLEDA
YISSQRNHLETVASALDRQLQFSVDKMLFFRHSMRDALETPLAFGVLHDAVKRFARLRAS
PTWQIEVDKQRTLPINGVSDAFVEKTTLLNRDDEFLDNELSAALEVGYLLRLASSSSGNE
ERVIYVSRAGFFLETDTPENASDIVQRYYYLVTQPWFTQQSERENRARAVRWFISPPSSF
VGKKPLITASVPVYYNHVWYGVVAMDFTFATLRRLLVEAVGDNPEGEYQLYDSRLTLLAT
SGSSAADVNHFDAPELAQIAHAIESDSEGGIRLGSRFVSWERLDHFDGIVLRVHTLEEGV
RGDFGSISIVLALLWALFTAMLLISWLVIRRMVSNMYSLQNSLQWQAWHDPLTRLNNRGS
LFERAKILAKQCEQQALPFSVIQIDLDCFKSINDRFGHQAGDKVLSHAAGLIASTLRTKD
IAGRVGGEEFCVVLPGMTLEEAAEVAEQIRERIDSKEILIKKSTTLRVSASFGVSGAQEK
GNYHFENLQSTADARLYEAKQRGRNRVIWQDHVKK
>A0A0U5II35|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MPSEETEPPLTQGAVETPDEDYRLLVENQTDLVVKVDPEGRFLFVSPSYCRAFGKTKDEL
LGRSFMPLVHEDDRAETAAAIARLHLPPHHCYVEQRAMTVWGWRWLGWSDTAVLDGEGRV
TAIIGVGRDVTERKAAEAALAETTRRLELAVEGGDIGLYDGSVLPLDMSVDARYLAMLGY
GVGEIQVDLQSWQQMLHPDDRDRVRTLGEQVVRGDLDRFEAEYRMRHRDGHWVWIQDRAR
VYERDADGKAMRVAGTHMDITRRKVAELKLEYLVDHDELTGLLNRRGIWQSVQRIHAQSQ
RSGRSCCLAILDLDHFKLVNDAYGHGVGDEVLKWVSGRLRQEVRQADWLGRWGGEEFVIA
LPETNEVQARTGLERIRESVAARPIQIKGQQIRVTLSIGFATCQSDEGDPREVLARADMA
LYHAKNAGRNRVCYDGHDSGVYAVSMAVLVQSALQTARILPAFQPIVELRDRRVVAEESL
ARIVAADGRILTASAFIEIAEQLGLLHRIDSMLLSATAARLKCSKGSGASRLFDFVHLSG
DLVRHPDILQTLARELDGVSKATNAAPPLVLTLNERQISAETEQVARALAPLLDLGCRIA
VSDYGGDTSSFRFLIHLPVSFIQLDANLVRLTSESARARSILATIQHTAQDLGITTIAKQ
IEDDATLQRLIELGVDWGSGYLFGRPSEPG
>A0A2X7FKX4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSVLLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A485JE83|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKISPMSCMTYVPTAIFPGRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A2X3JI02|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKSLTVGGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAG
LIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMI
AFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENAD
ISSLRERIQQQIRGEYHLDDVDLYYPGASLGIVEVDPETTDADSALHAADIAMYQEKKHK
QKTPFVAHPALHS
>A0A377CIA3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKTAFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQ
VLQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARH
LNHKIMIAFIDLDNFKLINDRFGHNSGDLFSHSGWRAP
>A0A5F1UUC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHRRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A376ZYD4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELF
>A0A768NAU6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASNEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A6L7CMH6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
EFYRIVRIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHAR
IEIPVEIVEMGFRVLKKILYPVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDS
SASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLW
FNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQII
TLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSVLII
>A0A826YP22|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MDNDNSLNKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATMT
YSLEAAVVFADGSAATETLAALGQQGQFSTAEVRDNQQNIIASWRYTAREPGDRFSNFIS
HWLFPAPVIQPIRHNGKIIGEVQLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRNCINTLMSDSAVRETSALLFLDGDNFKYINDTWGHAT
GDQVLIEIAARLMEFSGKRHQAYRIGGDEFAMILYGVLSEYEVQRICTALTQTFHRPFDL
HNGHQTSMTLSIGYALTREHASAEKLQELADRNMYQAKHQRAEKLVK
>A0A854BZG2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDDHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTVSVPVDS
NNYWYGVLGMNIPVRTMQQFLQNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTSMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTHLYNRGALFEKARQLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRALDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSSTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A5F1DZ98|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVAQVDPLIRNKAAEIAVTHAHYLSVEFYRIVRTDPHAEEFLSNEQ
VERQLKSAMETWIINVLSAQTDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSPSEKLQVYHFSINSIDIAMEVMTRAFTFSDSSAAKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFHQAMLNAKNLSNKSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENDTLRTAERIRSRVEKTKLKAANGEDITLSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3J0QZ60|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLIEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A826J752|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWLLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNETLFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIVHGIASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A8H2HA96|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYASRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A6C9J863|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVILLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEELFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQVAAHSERAVMSLDEQWRMIKENQLMMIAHGVASPRIPQVRNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAIASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAASVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCASVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A6D1C9R5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNFCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A2Y0U594|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALIAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8G9DIP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLKNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRSGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8H1VNI5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLPLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFNNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANCAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A827CXH0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLISSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLNHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8G8RPK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDDHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTVSVPVDS
DNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGNIFDPRE
LALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A8G9VXP1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFHSVVARDASKPEITDNHSYGLCQFGRWIDHLGPLDNDELPYVRLMDSAHQHMHNCGRE
LMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTVRSNMDVLTGLPGRRVLDESFD
HQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGE
EFIIIVKATNDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGR
ADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A369G0F7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETHFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQNVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISISLPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A6D0L3G3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLTSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAVHSEQAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSCSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQMENSPLPPRLLHLVIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGDLCANVQGNLMDEMLITIILGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A1C3RF85|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MKPHMSTDSTSHDPEEGANFNVLLGGIFLALILWIIGSGFAWKSYEGEVSQAEDHLENLG
NRLAYHTSSSIKTVDLAMMRTVTHFSKEWQSLKDNPVMAHDQLATAFAGLQQLKEVHILK
AGGESLFIHRFDYSQFKSITDDKFMVRLLRNPKRQLMIGPLQGAHSIGLSRPIYDPLGKL
VGYVVAKIDSNYLKKIYTIGLKDHSYRFALYKAESRLLSIPKQQSFDHDISMILSGEKRQ
LSVNHADRPYDEATLTTHTQVPNFGLVISTELPFEKIIAPWREQTVANAIIGLIFSTIII
LSANQVQRTFHAVHSENHMRRQSESNLRKLSQAVEQSPVSVMITNAEAAIEYVNPKFTEI
SGYSLEEIIGQNPNVLSANIETKTDYSHMWKQLLQGEEWHGEFCNKRKDGSIFWESASLS
AIKNTHGQITHFIAVKEDITHRKQAEEQLELAAAVFEAASEAIMVCDENNKIETVNSSFS
DITGYTIDEVRGQPPSMLKSGRHKEQFFAQMMEALLKTGRWEGEIWNRRKNGEVYPQWLS
IKTIQDDHGKIIRYISLFSDITNRKKDEERILYQANYDALTGLPNRSLFLDRLQRALISA
ERSHTKIALLFIDLDRFKHVNDTLGHAYGDLLLQEAANRLTSLVRKSDTVARLGGDEFTV
IIADLTDFRQVEHLAENLLAKLSAPYDLDNNIAFVSGSIGITIFPNDATNVEDLLKNADT
AMYQAKENGRNLSQFFTREMNDEATERRALETALHQALEREEFVLHYQPIVDVQTGNLSS
CEVLLRWHQPEYGNVYPDKFIPLAEDTGLIIPIGEWVLQKACREAMIWAKKTDTPPGVSV
NMSSRQFQRINVVELVQNTLEMTGLPAERLTLEITESLLIVDDETVIEQLHKVRELGVGL
SIDDFGTGYSSLSYLRRFPITTIKIDRSFILDLTSDSEAAAVVSAILSMAQSLNLKVVAE
GVEKETQMEQLRKGGCEYIQGYYFSPPVPIEAFRLMVLKEGPMQPDE
>A0A0V9H736|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLSV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPIGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLFISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVFASDNA
>A0A777GRP4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIARDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A1C3RGT9|diguanylate cyclase|EC 2.7.7.65|Candidatus Terasakiella magnetica|TrEMBL
MASPSDISPSHALFASIVQNSDALMCLCDHEGNFIYTNPAFEKKLSLPEQTQTSFDEFFT
STPWAKICQPGNWQGEATTKDGLWFRTTLSIAANPNTDEVQYVLILQDITEQKEQEKSHY
FDQQKLKSILDNIPAYVFSKDKEGKYTYVNKMLSMLLALQTDDILGKTDFDLFTQEAAQN
FAKNDKAVFTKGKTIRALEDGGIDEYGIERSYLSVKCPLENEQGEIDEMLGMSVDISEQQ
RLEKALWESQEKLNSILDNLKARVYIKDRDLKYTYANEELCQTLQKDRSSIIGKDDYDLF
EPETAIGFRTTDQEVFKNQRKVSRMETSLEPESKKKRYFLSVKVPLLNAEGHAHSLLGIS
TDITEQKRLEKRLLRNEKQLTTILDNLKAHVYIKDVSSTYTYVNANMCEYLGKEADEIIG
KTDVEIFGKKVSDRFRKSDRDVFDYGEQSSSIEKSRHFQTGERCYFLSIKAPLVNDLGNP
YALIGISTDVTEQKRLENELRTLASTDVLTGINNRRFFLELCEKEIERAQRYSKKLSLIM
LDVDHFKRINDTYGHAVGDEAIRAMTGLCRKCLRNTDIMGRIGGEEFAILLPETDKKGAI
HIAERIRQSTQDYAFDIGEENPVSFTASFGLTSLEDGDKTPDDMLKRADIALYDAKTLGR
NRVSEST
>A0A789AY14|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFHSVVARDASKPEITDNHSYGLCQFGRWIDHLGPLDNDELPYVRLMDSAHQHMHNCGRE
LMLAIVENHWQDAHFDAFQEGLLSFTAALTDYKIYLLTIRSNMDVLTGLPGRRVLDESFD
HQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLIGDVVLRTLATYLASWTRDYETVYRYGGE
EFIIIVKAANDEEACRAGVRICQLVDNHAITHSEGHINITVTAGVSRAFPEEPLDVVIGR
ADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376LIZ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVM
STRDGMTGVYNRRHWELCYAMNLITVGGITAMRHY
>A0A2X1LHF9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MWKLQHYYPLFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMN
NWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLD
INKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRV
SLSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILT
PELEQRLQKLVQSGSSVMFIAIDMDKLKLINDTLGHQEGDLAITLLAQAIKQSIRKSDYA
IRLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTYMMRIK
LPMSVYMSISRTKNSRS
>A0A376S6Z3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVQPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYTISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVARDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPEMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGCASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A5I2YTR1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Durban|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A377ZYF3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. ozaenae|TrEMBL
MPELHTPANRPGPAAVARVTLLPALLVIVAVAVGCALVSPPVGTRHEILTNPGLYIDLLA
LLFLVFMLWSSAKVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLLTVVGVYKVIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGHALGLMILD
IDFFKKINDSWGHLVGDEVLFSLGKQLAKLTSEQVQPARIGGEEFAIIVDGLSEPELHAL
AQAILANARTILINHQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWAP
SAGAAG
>A0A377DWE7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVIYPLLFGWVSYQTGNQLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITPAR
>A0A7W8NH65|diguanylate cyclase|EC 2.7.7.65|Deinococcus humi|TrEMBL
MNPLGILNELLVNLAMLIAGVTFITLTSQGQDTRESAVRLLLRYSSSVLLGLFLMTHSVG
LAPGLLFDFRGVVIALAARRYGLVAGLLVALPLTLYRLSLGGAGAWPGVANLLLVAVLAG
AGTGLARRIPRYQEDTVAHRVWTALVLFGIAHLPIFLAFFLAGKPVVQALPIYLTLTVLS
ALGLVAAHLVKQSRLQSLSQTEQLKQLVFVDPLTGALNRRRFDEDFRRTEQPAFVLLLDL
DQFKQINDTFGHERGDSVLRALVRTLQETVRSTDGVYRLGGEEFAVLLSPCDEMAVMRVA
QGLRRRVQDLVAARAGLGGEQQVTVSGGLVRLDGEKRDVLRSADKLLYQAKSAGRNCIMT
NLPLGPMADGSECRPLCSTGMLPALG
>A0A377A1S2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARL
>A0A2X1NK45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGSYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A8E6UGG9|diguanylate cyclase|EC 2.7.7.65|Escherichia sp|TrEMBL
MQAPGIPENEEQRLKSLYITSLLDTRDDERFERLTRLARKAFQVPVALISLLDRERQWLL
ACQGVGVRETPRDISFCGHAILQEGPFIIHDAAADARFHDNPLVTGEPHIRFYAGQPVSL
PDGTVAGTLCLIHTVPRAFTDEDIASLRDLACIVEDEFEAISMAMTDSLTGIPNRRGFYR
AGEKLFRAMNRQDASFSLIYFDLDRFKPVNDLWGHAEGDEVLKIFAGFLHQHLEPGEIAG
RLGGDEFAALIRRNGNTQSYLHALSASLDHYNDTSGKPYNINYSFGELINNADHYTTLAE
MIGKCDEVMYLKKKRKTLSRKTEP
>A0A1S7LE13|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MKVLFVDDMATVRLLYGRLLERAGHEVHLASNVAEALELADTQHPPLAIVDYHMPDGTGA
DLTRALLAREATAETLVVMHSTSLDVIAESLEAGAVDLIHKEDPKEVFLMRVGAMVRFIE
TQHAHQEAQNAAQARALEATERMRQVEEQARHDLEHRVAERTQELTNTNARLTEEMKERA
RAETDLRLIHKVFENTSEAIILTTPEGVILDANPAFSEITGYSREEAVGNNPRTFKSDRH
EPEFYTRMWKQIQDEGFWQGEIWDRRKGGEIYPKRLTINAVRNHKGETENYIGIFSDISE
SKATELKLERLAYFDPLTSLPNRSLFHDRLEQEFFNAKRHHRKVGVFFIDLDRFKQVNDT
LGHSAGDELLRHVAQRLEGCVRASDTVARMGGDEFTIILTEINDDEDAARVARKVLGELR
NSISIKGHDIYVGASIGIAIFPDNGGDVENLTKNADMAMYRAKESGRNNYQFFSEEMNIS
TRERLSLESRLHEAVELQQLEVYYQPKMDMHSGRIVGMEALIRWPQADGSIVSPGDFIPM
AEETGLVVPMGRWMMQQAARHCYAWNQRSTVPLRVAVNLSAREFQSPDLLEAIAGVLEES
GLSAENFEVEITESMMMDDVERSIETLKKISAMGIHIAMDDFGTGYSSLSYLKQFPIHSL
KIDRSFVQDVPDDVNDVAIVTAILSLAKVMNLKVVAEGVESMQQVRLLHELECDEFQGFL
FSRPLAPEAFGTLLEQDAEKGQELLNEVRV
>A0A379KTF1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MTEEAERWKEKYLKAIEQQEKLERRWDARLDLLRRGLVRSTLAAEGSDKVVDACMKEMRE
VIRSDNMDAGLAGLIPRLEKAVLDSEQRRENRMNQVGDALAALVGQLQNLPLPGDIARPL
KKLAKKLDGGVTQSRDLPPLLGELSGLQGRALAALGKPGEETRPGFLQRLFGSRDDDAQA
EPALVPEAVPGAQAPPHAAPPSPDAGPHVDIDALQPLPAPAAPAAELPAAPEPAPDAAGP
ALIEAAEVPASPVPQPGEGPAAEHGVSQPLPAPAPLAELEPTFGEDGPYALPDAVEPPYS
QVAAHIEQTLLGLLDDLSLPERHKAQALEMRARVARGLNWYELIPVLDDLAVLMLAITDS
GQHEFETYLQQLNERLEGFQSHLHEASAGHADNSSAARALDTQLREHVDGLQSSVQGAAD
VDSLKHILENRLEGLLVTMDEHKHERDRREQELANRLQGLSERVASMEHEALGYREHLEE
QRQKALLDPLTGLPNRAAWSERVEREMLEWQAQGGHLAMAILDLDHFKRINDSYGHLAGD
KVLKIVADQLRKCLRGRDFIARFGGEEFVLLLPQTAPPAAAQAAELLRATIEACPFHFKG
ERVVITTSIGLAAFRAGERADQVLKRADTALYRAKELGRNRVEQN
>A0A1S7LIR9|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MNQAMQSYTPRLLIVDDAFAERLPMRAVLEQEGFDIDEAESGQEALEMFNKGRYDGIILD
VVMPTMNGFETCSEIRKLASGRLIPVLMVTGLDDHASITEAYNAGATDFLTKPVNWDLVG
HRVRYLLRSSRLAQDLDLSQQELVEKQELLDAFINNSPAAISIKGLDRKYKMANPEFIRH
CVYKDKNVFGSTDHDLFHKGFSNQVTEHDDLVLKEKTPKRFEEHCLEEECNKVHFSVRFP
ILNAQGEATGVGCISTDITESKKTQESLLLARRVIESTNESIMITDPNGVILDVNSAFEE
MTGFGREEVIGNKPSLLKSGRHAVDFYKEMWETLLLTGQWEGEVWDRRKSGDVFPKRLAI
SAVKNSEGMTQYYVGISTDITTQKATEEKLQQLAFYDPLTNLPNRTLFRDRLTHEIDQAA
RRKDQFAVLFIDLDRFKHVNDSLGHDVGDELLIQVSKRIESCLRRSDTVARLGGDEFTVI
LSSESNPHVYAQIAEKIISELRQPFHIRERQLYIGASIGIVSYPAEGLTYEQLTKNADTA
MYRAKAAGGSSYRFFSPEMDKENMTRLSLEEELHMAMERDELALHYQPKVDLGSNSVVGV
EALIRWHHPSKGMVSPVQFIPLAEENGLIIPIGQWVLETACQQARSWLDQGIDSVRVAVN
LSGRQFQNPDLLDDIQVTLDRFNLPRGSIELEITESVAMDDVEKTVAIVERMRTMGLHIS
VDDFGTGYSSLSYLKKLPLDCLKVDQSFVRDLMSDSDDAAIVDSIISLARSMNLSVVAEG
VETSDQLSFLKEKDCDEVQGYFFSKPLPAEAMTQLILNPVQALQAAG
>A0A1Q9QUJ7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MEQRKSGSFAILRLVQARARGNPRRTVLLCFSVLFLITLVLACRQYWLVQERELDHRQYS
LHLQAIVMETALATERREMHFLRATAERTLLAARELPGASSAPLSTGATTGIEVAAGDAP
VRIISDEQVRAIPGLSRSPGQLAEDLRLARWMSRVLAVLFQGSNQQDHLFYVSSSGVMVA
YPPIDDQHVEPTLRQFAASRLFHDESSGEFEVRFKAVQGQVFSSDPRLLLGTPLRIDGVL
RGALVFDAPQQRVQEYLYRTTPVDEAHVLLDGEGELIASSERHFNAEQGLDGVFGAAADP
RSDLRGAGLVDYGQGPVLYRELEGSRALLLAHIPAASLRWAVISQFSTLFVCLWVSLAAL
MVITLLIVDRLFRSQLALNERMRDLGLVDPLTRLANRRRLQTDFDGLARRLKREQPMALL
MLDIDKFKRINDNWGHSTGDEVLKHLATLCSALVRPQDLMARYGGEEFCVLMPGVAIEQA
SAMAETLRAAVAQSVCLPNPQTMLSTAPSPEVRLTISVGVAEVLLDDCHSLEELVARADR
RLYAAKQNGRNQVVADDALRVV
>A0A3P5XU24|diguanylate cyclase|EC 2.7.7.65|Filibacter tadaridae|TrEMBL
MLNSKKQRISIFFAWLLIVPLGVYNAYSYSPSLPIDWENVIFLFAILFITMFLPFKFQNV
MISLERWITFTIFFQYGLFTELIFTQLAMFLLLFGSKTDTPALHRFFINSLIFTLVSFIS
GYIFHYMGGVIGSLDFFHISLFGLLYAVSYTVLNSIIMQLYLYFEFGVFTFWEKHIAWDF
LVTMLLLPFAIALYFLYEHLGNKAIILTGIPFLIILLIGKMYNQSDNLNGKLSSASSVGR
KLADQLRVDDVIKTFIEKLKDVVSYENAYVLDLRSGEHLYLLMSSENGLISQNASCIDFK
SLKEENDGLSLDVTTILRSKKELRSLKNFQFLDSVKCVMTAPIRRNQKTEGFLILTSNKK
NVFQSLERKIVDILTGYFAISLVKASYYEKTIENSERCGLTHLYNYRYLDATLDEEMIRL
HTREIASLSVIMMDIDHFKSINDTYGHQSGNDLLVALARLLEKVVPEKATLARYGGEEFV
IALPDIEKEAAIELAEQIRHEVDQSLFTIVPDLSEEREPVDVHMTVSIGVASVPEDADDA
KALIRNADRALYIGGKQAGRNRVGVYGGDKSIHV
>K4XFY9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O111:H11 str. CVM9455|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLHWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A5E4VSV9|diguanylate cyclase|EC 2.7.7.65|Pandoraea cepalis|TrEMBL
MTTHRPSSPPLPPGASSVAGLLPADASAEGEREPPLATSHLAAPDPMRGRRPSLQGMLRR
THLRLAVSAVVLAAVSLSLVAWIALRAYAENNLLLIGRSLAYTTEAAVVFGDRLAAQEAI
ALIASDEDLAQVRVFDANNAPFAQWRRPDGGALTQVERVIANVALPGPVTMPIRHDGKVV
GTIDVQGQGHQFFLFLLSGVGGVLACLLVTFAVANVLAKRMHRDIVKPLRALAEVAHAVR
RERAFHQRVAATPLAELKELGDDFNALLDEFEGWQNHLRAQNATLAHQANHDRLTGLPNR
AYFESRLVQALADAREMGTHVALLYLDSDRFKEINDQRGHGAGDVVLMTIAERLRQPLRE
GDLVARLGGDEFAVMLVGVRQTSNAVRLAQSLLVAMEKPIVLPDGGEIVTSMSIGVALYP
THAEDAAALLRTADAAMYQAKRAGVGTWFVAGSPKG
>A0A1V6AWP2|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin151|TrEMBL
MPISNLDKIRDGLTNALSRGWEERAIMECRDIIKTAFEDAGNGLWEWNLKNNKVRFSKMW
KIMLGYETTRLGNDIYDWKRMLHPDDREDAFNSLSSLRKKRSKISKCEYRILHSDGTYRR
VLNVAKAITNEGNPVRIIIMQKDITRQGLMEEKLRESEQKYLVLLEESNDPIFTLDLQCI
FKYVNRAFARAVNTTSEDIMGKSVWHIFTRYEADKISVMVNEVFESGNHNVIEMQLPRSD
SVRYYMTSIEPIKAQNGRVASVICSSRNITEHKEAELELIKSRDLMSKVFENFPLAVYMK
DYKKEGMYVIGNKMWDDLHKNSPMLSSVLSEFEDAALSTGSAVIFEHTVPEKDGRMKTMK
SNLIPLYDQRGQLEYLLGISEDISDLKQMEEEIITKDAALAQASTEKAISALVAGLSHDI
NNALGGVTGGQDLTKMYLGKSERTIDKIDTGRMKLIDTIRSCKTGSKGISRHLEEFLHEK
LPDHLVDLKTNIQASRKYLTYVNNGGLIIRDVTSGIRDYVKQDHSLNSFEIRPAIRGAVS
LSKGQYKPMAQDQGKTVSVEICDASPSATVFGNAGEFMGIVVNLINNAVAEFPRGCTNLI
CISWEKEKNVNSEDVIRLRVSNDGPPVPDHILTHLFNEKV
>A0A2N7QUZ4|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MPLSDPSTRYGWPPAVAGFDMPSPTHAGGDDAEPTMLALLNGRPDHFWMEAFASEVDDFK
SQHRLRDMRLDTRGVVVCGTVSQLRSLTTELRNFVHRVSRISLQRRVMERLTLGGVSGAT
AAENTAARHDVDLVAHMPAIAAILEEVSRSTGMRFATLARVSDTRWTACAVYDTIDFGLR
AGEDLALETTICNEIREHGHTVVFNHASTHPRFANHPTPALYGFEAYISVPIYMADGRFF
GTLCAVDPQPRELDQATVQILERFARAIGLELDRAELLSVQDDDDLDDASPATAV
>A0A2N7QVZ3|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MPSTVPSGESINRRFRYIVTTLYLVVVGLVLWLFGTQWRGYWDAYEADKEFIAVQAALRA
MADVSSERRPTFAVLVADAAPSAEQLNAMTAARQETDTRLNKLGTALHDPDCRHCASLVP
QWERTRSQLADARQHLDALRSMARNEHTNTAALDGFAHLADTIPQLSSIAETGAMGVIRE
NADVQSYLLVARLSALLREHAGMLVSQFAPALIARRTLTEQETFDIARTLGKIDQLRLLM
EPSIRVLPALLRSDYADIDKRYFGDALTLIDHLRQSAQRPSGADELPLRVYERYGPLIIP
INRFRDDALALTQSTIRDSLRWHLIYLVASGIFAALLTGLLLLMIWRFRERIIRPFVEAR
RVILAIASGNPSVSLPRKQYGSEVRELFSALRVLKENDARRLKLEKERKRLIGELKTMAE
TDTLTGLLNRRAFESRSHVLLADERSNDPVVALLLMDIDHFKRINDTYGHDSGDKALVLL
ASVCRETVRADDIVARFGGEEFVVLSRVQESQQAHALAERLRLRLHDETTVTADGQSFGF
TVSIGVAFARRDDGNSIDVESLLREADALLYRAKEGGRNRVETAPLA
>A0A729G4C2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 48:z4,z32:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A377HNC7|diguanylate cyclase|EC 2.7.7.65|Grimontia hollisae|TrEMBL
MSFSQYKTQFKEVLSSTSHAAAFNTTRATYLRTRLVSLCYLWAVLCVLWIPVDALLLEAA
TDKLTILRLTLAAALLLIGWVMSQRGTLNACWHIMLALVVCLNMFYILANHTLGYPNSIN
AFSYCYNLLPFVYVVLLAILPLTVKESVSLMVITAASQLYVDMQSSALLSFETFALYWLQ
TVVGFLVIWAQTSKLHMMLRLYRHATLDPLTGIYNRRMLLTLAKRDFENTRIHSRPYSVL
LMDLDKFKRINDRYGHHAGDLVLQAFTHAVQETQRKSDIFGRFGGEEFILFLPKCSEDNA
QLVADRIMTRVRDMEIKVEGLSNPLKVTTSIGISTSRNQNDDLSSILTQADQALYIAKNA
GRDRSHAYDNHQQQMDANQKQPWLERLS
>A0A7W6RTY0|diguanylate cyclase|EC 2.7.7.65|Rhizobium mongolense|TrEMBL
MEISEIVAAYIRVLALAVLVVYGYAWVIRTISQRLMRGVAAGLLFGLGGILSMNDPIVMR
PGLIYDARSILLILSPLYAGPIGTIIAAAMMGAHRLVLGGVGAMGGAVSVILVALCGYAS
TLIPRHRIGTGWLRSLLLGLATVSSFIVLVFLPPEVAWDLFLSAAAPVMLANILGVLLLA
DLLEREKQRVRMVRALENEASVDPLTKLPNRRVFQRAADRCAEEASNRGRPFSIVMLDVD
HFKKINDTWGHNVGDTVLSRVADLIRRTVRKTDVAARYGGEEIIILLPNTEEGDASTVAE
KIRHAIESEDLIVGVTAIKVTVSIGVAVVDSSGTNIRATIEAADRALYRAKTAGRNRVEL
ARAA
>A0A8G1KXR2|diguanylate cyclase|EC 2.7.7.65|Qipengyuania aurantiaca|TrEMBL
MRFYKATSFLFPRHYPARMFALCFGAVHIPLVTFLVFEALRGEWHWGIFLALLVATVVGS
VAAILGIHGLLAPIDEASRALRAMRDGDLSRPVPIGGPDLAGHLLESVAHASRSTADKID
NLQELANTDLLTGLLNRRGFFEAMDAREKMSGTLAVIDTNNFKRVNDLHGHLEGDRVLRM
MGERLREVMSGEDAAARWGGDEFLVFFAHRSEDEATKALATLAQGLERRPLTRIDGKPFG
FSSGTTAIDENDRGLLDAAVARADEPLYRDKRRARGLVDA
>A0A174YR61|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MSNRKYIKSLLLGMSVMMTILIAIQIYLTVYVLKHNEMLPRILSCTALILDIIILAVFFV
SSRINADVDSMAYTDVTGINNKLAYQNHIIRLNNADDTFLVGVIMFDLNNLKRVNDTLGH
EMGDRYIESFSAILAGVQNERISAYRIGGDEFCVILEKTNAVEIHQILDSLERKINVYNE
KNNIKISYAKGYEISTREHYYLMEELTKRADSRMYENKRLMKGKRLDGRRLNV
>A0A174ZVT2|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MSNRKYIKSLLLGMSVMMTILIAIQIYITVYVLKHNEMLPRILSCTALILDIIILAVFFV
SSRINADVDSMAYTDVTGINNKLAYQNHIIRLNNADDTFLVGVIMFDLNNLKRVNDTLGH
EMGDRYIESFSTILAGMQNERISAYRIGGDEFCVILEKTNAVEIHQILDSLERKINVYNE
KNNIKISYAKGYEISTREHYYLMEELTKRADSRMYENKRLMKGKRLDGRRLNV
>A0A0M9EIH3|diguanylate cyclase|EC 2.7.7.65|Shimia sp. SK013|TrEMBL
MIRTSRDRNLFVISWTMLSVAMSYGISFPLLGIPRDANIVAAAILCPLIIAPIVAIWTGN
MMLRLHETSLQLRAAAERDHLTGIYNRQFLVGQLGSISGAQKAVVLMADIDHFKRINDTY
GHIAGDRVITYVAQNLTENCRDGDAVARFGGEEFAVVMIGASLEHGLSSAERMRQAVADA
DLVIDGRHVPVTISVGVAVRHDSQDANDVLHAADTALYEAKENGRNRVQLAA
>A0A174Z1Q6|diguanylate cyclase|EC 2.7.7.65|Lachnospira eligens|TrEMBL
MASGFIFSTVDEVTPADKRTSVIVKPEDTRYIGNDTIEYYVKIRAGAGNNNALAFVSRHQ
EVEVYAGGRLIYYIKAHSSIYGTTTGTNYTIVNIPPYTTDITVRLTNVYAGHKIRGTTFE
YGDETKLVKELIAKSLPSAVLSSFIIIVGFAMIILWIFCRKKIAQTQALFYFGIFAMIIG
AWALNETDIATILVQDRKIGSLIGYVLLMMIPIPFMQAEKNFFQIGKSAANNILCAIYAA
TAVILLVCHMTGVCEFKNSVYIIHMMLVMSLVYFCAILIKRVWVKGFDRKVKANIIGAAA
LGISMIVDLIAYYKGMQQTDLIGKLGILVFIIVLGYESISEAFEKIKEGQKADFYKEMAV
TDTMTGVYNRSAFEEWEYETSDYEGYSIATFDLNNLKWCNDNLGHAAGDAYIQASARIIK
EIFGRHGKCYRIGGDEFCTVINQKQKSFDIGRHVKQLRELEKYAEEEIGIKDLNVQIACG
YAEYDIKTDKNFEDTRSRADKKMYESKRSLKRE
>A0A5W7MKV0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Cerro|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1R3U203|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MTIPASNKSRDTSRSSLIVTKVTQFITKMNLAPLPRNYELFFEVLAGHNAAMGHDILALG
NAPQQHDIDMIGQKHNLPSFSRMAAAHATSQAASAIEQISARLSAALERSEALLSSISDR
APSDTTQEYLAELLLDIQHEQASLHNFVRQGLEKIREQESNSHKLQAASLKDTLTALPNR
AAFLAKLAEVSQAEGDTSVCLVLVNIDRFREINEKYGTIAGNKALRRLAALFRKSIKKDD
FAARIGGNDFAFLFSGVSQSTAQSIAERLRHTVENLRFATKEGDGEHLTVSMGVAASEGT
ASAAEFYGHAELALLAARSGARNCVIPYSREVAQRSRNSYLMQIGA
>A0A1F2PHN0|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNSNRKLLYKVVQLVCVVILGIVLFNIFQLVDIIQGTGRVINYTGIIRGGTQRLVKLETN
GIPKDDLMLYLDGILNELQTGQGQYDLDKLDDIPYLEKLSELNDYWDELQTEIMIYRSDP
GNKEKVVQMSETYFNMANDVVGTAEFYLEQKTKVLTSLELVMVILLGLLIVISLQQAITE
IHLIRKNKELATAAYYDKPTGLPGRLSCEEKIWTPMDRKQGPYCMVMMDLNNLKWVNDTI
GHSAGDTLIKAFADILNHLTNENVFVGRYGGDEFIMIIKNHREEQIQQLLKEIELATILY
NKKSEQLKIQYAVGYEYGGDSLPQMLEKADEKMYLNKTAAKADTNDL
>A0A8G0TX45|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MFKDEDETTQSSTLRVERLKKRIIRLKYLAHKYKRAEIIQNALLELSNIATQVSSLEEFY
VGVHQHLKQLISADNFFIATLDVASGTIAVPFFADEKDAHPAQLYPEESLSTLLQQGLTG
YVFRTGRALLCDNDKVDELIAAGEIVNLGSPCHLWLGVPIKHDGIMTGVLVVQTYDTNVN
YGDIEVELMTFICHHIAGVMERLKHQEQLEQAIQQRTKELSQAYDKLKQEVYERRRAERL
QKSLFEIAELASSGTDTPDFYSQLHNVIRHLIPANNCYIALLNEEETHLTFPFYVSQLGN
KHPGTRPLQDGLTEYVLKHKRPLLLDQNDINTLITSGEIYTQAPSLNHTQTMHQWIGIPL
FIHDQVRGALTIYSFSMTQNYQIKDLELLTFVSQHIGAAIEKKLSAESLRRSYEELEEKV
IARTKDLAELNKDLEKEILQRRSMEAKLVHDAKHDALTGLPNRAMFMERLNQAIKHVRRH
SLEQFALLFIDLDRFKQINDTLGHLEGDRFLIETASRLRSCIRDNDTLARLGGDEFVILL
DSINSINDAKDISERVIQTISQSYKLGSVEFNSGASIGITVSGNHKFDTSESMLRNADMA
MYQAKANGKGCYVIFDDSSSQQAMQDAAFENDFRRALQQSELQLNYLPIVDLNTQEVYAL
ESCLFWEHPLRGTVQQEQLNALAEQTNLIVELDKYTLAAVNRTYPQLLRSYGDKLNLHVM
LSSQHIKHKHVLRSLKNVLKQTQLNLSRLWLFFSEKALVQETENHINGFELLDKLGVNLG
ISHYGSGHSALNNLLFLPIKGLKLDANITQQLVDEQHIKLISAYQKAASTLGLQTFVDGI
KSQEQIRIFSSLGYQFGQGIALAETFSLADNQQQDCA
>A0A1C6E508|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MSVFILAVGIGLIFFYVVAQKTIDSSSQERMKTNVARQSEHLRTILNIHYSYLEGVAEKI
AESNELMNEENKEVLTVFQKNTSLDRLALIDPEGNAYYDNGVEKNVSHRRYFKEGISGNR
TLSDPLESSVDQETRVVLGVPVFHEDEVIGILCGSCNVGELSQMLFDDLFSGNGYSLIVT
REGKIVAHTGDPVDHKFSYGEDIFTFYESKTTREGHSIGEVKQNFAMGEEGLVRLAGYAD
GSDRYLAYAPLGINDWMICYVASVTVAQQSYAFVEKYEMVFLGCFGILVCLLILYIVRKN
RQKTEAILQSAQTDELTQVYNRKYAERFAENALEEAKDGSIHAFFIMDIDRFKEVNDVYG
HAVGDAVLHTFGALLGRQFRGDDIVGRIGGDEFIILMRNVTTKEAVRTKAEQLLAETKKL
VFDEMAGRGITISVGIALAPEHGKTYLNLYRSADQALYETKRNGRNGFTIYGENRDITGK
R
>A0A087E9P9|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium subtile|TrEMBL
MLNTSAHQTSPRTILVVEDEPDLATAIAQRITAKGWTARVASDGASAVRAASQLKPDLVI
MDIMLPVMDGVEATKRIVAERPVPVLMLTARDAESDKVMGLGAGADDYMTKPFSPRELIA
RCEALLRRVERATIIAKNLENEKVLDFGSLVIDPRQRIVTMDGEQVHLTPTEFDLLATLA
RKPKSVFKREKLLEEVWDWPDASGTRTVDSHVKALRHKLGSDMIRTAHGVGYAFEPPQDG
EASSER
>A0A0M7HHY2|diguanylate cyclase|EC 2.7.7.65|Bordetella pseudohinzii|TrEMBL
MLAPSNLLLITALAALIDLCVLGSLWRSGMPGIREAMGANVATIVAMLFMVQQASAPPWL
GVLLANLLFTMGGVLFVAALRRFLDQPVPWRPMLGGVAVLMVALAYYTYISPDVSARIVL
ASLMYTSLLALLAWSVWRSRRQRFAYSQIFMLSLALVAILGHGTRMAVYALGVDAIPGLL
APTVWNIVFLSLGVVIMPSLTLGMIMMIHDRMLIEREREANTDFLTGVLSRKAWWQGAQR
LGARAGRPLALLILDIDHFKQVNDSMGHAAGDAVLRHFAAVASAALRPGDALGRLGGEEF
IAALPGASAQEAQALAARMLAALDAMPCQYGDIQLRYTFSGGVSSWDGAEALQTAVQRAD
QALYRAKAGGRSRVDLACPV
>A0A448CS00|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
METPAKSLRLASVYGVSLLIIFMVPLLLWQSTTAKTVTAVDWFDVVTEGALFVLGMCWLM
VMVSVRPSGRVTNLLIAGLSSYCLGCYLDLLDEIFIVKTIPVYNWFEKMPTPVGLLVLTY
GLWLWRDEQTVVNRQLQTREQFHREHQLTDGLTLLNDAKAFEQHLIRQISQNQSFGLIML
DVDNFHQYNESNGVEEGDRLLSQLALWLSASLRSQDLVCRYAGDRFIILMSGAIPPLVSV
MAEQIQQGVRELGCSVSVVWTLPTPKALDRQDKQNSPKAEAATLLQLLNQKISQQKADRA
SAAPITQPFHSRSTSTESGLN
>A0A1C6K0J5|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MKDRRKNKTKRKVLLALYLAVCLVIIVAAYFHLSRIARNFNTEHLELITGLYAEKMNDSM
EYLQNYVQEDIKMIRSMENAQPEEILEQLEKNLDKTVFGDIGFIMNDGEIYGSSSCAVSD
IKKKKLDEAALASDTSFNSDPYQSSRTGNMTMTVFVPVGDTSLVHTLYVSIMIENLRQLG
EYELLQGKINIHLLKADSENFITCVSDNSGTSGSWNNLLLQQKYFQYDAGYSYNQWIKDM
RSGKKDGRFSAIIRGEESTISYRSISVMPGWYVIVELTNKNISDITQQFSAWGGVYGSIL
VGFTILYMLTLVLLEKKDKKIYMGLSTTDPLTGILNRRAFQIAVEEELRKKTPGIFIFID
VDNFKIYNDTYGHNNGDFCLKHFAKTMKSCFPEDSIIGRYGGDEFVVYLKNLTGEMARTY
METFQRMISQLTLPTGEVVELSASAGGAAFPEQGEDVMSLCKSADMALYKVKQNGKADFK
MKGM
>A0A1V6BNX4|diguanylate cyclase|EC 2.7.7.65|Deltaproteobacteria bacterium ADurb.Bin135|TrEMBL
MEPLYQVERNIKIQLLLAHSLLWLLGIIGIVFAVNRVSAQVKQIKQSEEKLITMSLTDEL
TNLYNRRGFFTLAQRQMKVAERTKKDMLLFFVDLDKMKVINDTLGHQEGDKALIEVSNIL
KEVFRESDIIGRMGGDEFAVLAIDTANETKEVLVNRLHNTLNDYNRFEGRSYQLSLSIGV
AHYNPEIPSTLDELMTQADKLMYEEKRNKKH
>A0A1V5BR07|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum sp. PtaU1.Bin065|TrEMBL
MVDFYLFIILFVLFMYVLVANDITILYKVYLAFHYFLGMWPFCNFLINVIPDQQLQWIFL
SAAFVSLCFLGYGWHVFSLVLTGKISNARKLHLCLWAAPAVLCSLLVITNPWHYLFARPS
ADGWMTRTYGPFFWLFVFFIIIYFIVGGALMVNELATVSEKNKKKQLSLCIWGVVFFLAL
SIADVLLNTFVLPKSVIVPGLTSSGIVILTICFVVAIQKYDLFRIVNIARREVIDSMATG
MVIIDQNEVVLDINKSAGKLLSLQPGQVFDIKKFYPHSETESAGLFLEDYNQKRLKKLKT
EIVIRREQPRHITMHIAPVVDHKKNLLGRSITFNNVTELRKLIEKINEKNATLERQNDEL
LRFQTELYEANKKLEQMAITDALTGCYNKRYILNQLEYEIVAAHRYNIPFSLMLMDLDRF
KLLNDTHGHLTGDDVLRDVVEIIKKALRKSDIMARFGGDEFIIYIPQVDNEGAVVLANRI
KSMVENQIVKTMIGDLTVTLSIGLISVVNAESINIREDFLKELLARADSALYEAKLKGRN
RIVAEIIS
>A0A6S6XXJ3|diguanylate cyclase|EC 2.7.7.65|Denitratisoma oestradiolicum|TrEMBL
MFYGAFASLWIIVSGYLLTIAVDDPVLQGRLEIAKGLLFVAATSMLVYFLARRLGAPAAA
PDIRTFTSTRPPLAAAIGVFLIAALSSGILVRQSEQQRQMQHRARIANMAGDQAHAIQRN
IEHALSATHALAALVRQGQGQIPDFERTASEMLKFYPGAASLQLAPNGIIRHIVPLAGNE
QAIGHNLLQDPARNKEASLARDTGELTLAGPFELVQGGLGAVGRLPVYLDIPKPGFWGFT
TVLIRFPQVLDDVRLAQMTEQGYAYALWRIHPDSGERQIIAASGSAPLADPVDQSVDLPN
GRWTLSVAPLKGWHDPYGVAFKSALGLLFSLLLGYLAKLLVELRMYRQNLETLIEQRTLQ
LSTSEQRFRDMSDAAGAYLWEIDTNMVYTYVSDQSAHVKGYTPEQLLGHTPMEFMPPEDI
QSVGEIVNRAIVNKSFFRLQHRDITPSGEIWWEEVYGSVYCDEQGKVIGLRGTGMSINAR
KQAEEELCRSERRFRDVAEISADWIWEVDAEGRYTYVSEGVTSLLGYAPQEVLGRMPFDF
MAPDEAQAIGAAFAEIAAAKSPFSDLENIVLSKDGTPNITLTSGVPILDSAGGLLGYRGI
DRDISARRTAEQRVWRLTNLYAALSECNQAIVRCNSEMALLPEICQDVVRFGGMKMAWIG
ILNAETREIRPVASFGAGLDYLKDINITTDASAPHGHGPVGTAIRENRPVWNQDFLGDPL
ATPWHKRAEQFGWGSVAALPLHRNGKVVGSFNLYAGETNAFDEDARKLLEEMAADISYAL
DGFERDASLKLAAEVFEQGKEGIMITDIQGKIVRVNRAFCEISGYDESEALGQGANLLSS
GRQGKEFYREMWHSIDATGHWQGEIWNRRKDGHVYPEWLSISRVLGQEGKPSHYVGIFSD
ITQHKETDARIQRLAHFDALTGLPNRALLHDRARHAISMAQRSHEQLSVLFVDLDHFKNI
NDTLGHRIGDELLIEVGQRMKAMVREEDTVSRQGGDEFIVVLPGTDADGAAHVARKLIAA
VTVAFKVEQYELIVTPSIGIAMYPSNGENFEALSQCADTAMYRAKQEGRNTFRFFTPEMQ
EHSARNLQLEGALRHALERKELTLHYQPQVSLSNGRIVGAEALLRWQHPELGSVAPAEFI
PIAEDSGLILPIGEWVLRTAVQQMKTWLDTGMEPMVMAVNLSAVQFGHAHLPDLVAQILA
EEGLAPQHLELELTEGVAMDDPLAAIAVMDDLHGRGIRVSIDDFGTGYSSLSYLKRFQVY
KLKIDQSFVRDITTDPEDRAIVSAIISLANSLGLRTIAEGVESEDQLTFLREYGCQEVQG
YYFSKPLSPEAFAAFSRRLP
>W7WWZ6|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29-B|TrEMBL
MTDLLGSVVSLTGYRDRDLLDAAAVTMLADWLRPLSLSLYRCVGEAGDTRLLLQACARDG
PPAVAGDPPWTPLEALPSLDDWLPHRDALAGGEPLLALPTSRPGPRGRPVLLNVFPLWVG
TERFGLVEVLAEKPLDAEQLRFVDAVLKIYRNQVGLLDYSERDTLTGLLNRKTFDEQFGK
CLLECDGPGPLAPLSPSADGGQQPERRARASLRYWIGVVDVDHFKRVNDNFGHLIGDEVL
LLMARILRGAFRHGDRLYRFGGEEFVVMLHADSRVHAALAFERFRARMETCRFPQVGSVT
VSIGMTELRADDTPSAAFSRADLAVYHAKQNGRNQLQCHDQLVEGGTLVEAGGKVGEIEL
F
>A0A378IZS7|diguanylate cyclase|EC 2.7.7.65|Legionella donaldsonii|TrEMBL
MIPPDIPENEAKRLATLYKLRILDTEQEERFDRITRIACKLFEVPISVISFLEAERQWMK
STQGFDIKEAARKTSFCGHVILSDEIMVVEDATKDERFHDNPFVVGKPNFRFYLGCPLKI
KGYNVGVICLIDNKPRARNEVDPNVIYDLAQMVEMDLEQLQLSMTDELTGLSNRRGFLKL
ASYLFQKCQRQNQLFTLLFFDLDQFKSINDQFGHAEGDNVLKIFANCLLQNFRYYDVIAR
LGGDEFCVFCSGLNQKDVSGIIQRLKDSLKSATTNDYTIQFSVGVIQYDPKQHQTLGDMM
ALADSDMYVSKRGNSSLRDSL
>A0A6N3AD71|diguanylate cyclase|EC 2.7.7.65|Clostridium symbiosum|TrEMBL
MTVVFVCFAAFQSSLLAGIMVGSGVLKRAEQNEYRIFSEKVNGRKNNLENEMNNIWTNFD
YDEERISRYFEETDTGNLAGKEDEVLEELAPIILDSLYHTKTTGAFLILPGQDGTENSLA
SLYFRNNNPDKAGQNNENLYMLAGPWNVADKLKIATTANWSYRLELSSSNRDFYTKPYEA
ANEYGRSAWLGYWSTPFKVNPQDEDVITYSVPVFDGKGNVAAIFGVEISVNYLYRFLPAR
DLQNTDSYGYVIATGSMEKGLKLSITYGAVQRRMLEAGEMMELESVDEEDGIYRLLNHNS
SHDIYVSASRMGMYYHNTPFEGEEWYLMGLMEKPVLLHFPQKIERLLFFALLATTGIGLI
IALFVSVWFTRHAKLMELSGLPLGVFELRPHSGKVFMTSRIPSLLNLTWEQERIFTRDKM
KFTEFLKEFENLRDGGDDTFRLESEDGSKWIKITKKIMDGTVRCVVEDVTDEVLQTKALQ
VERDRDGLTGVGNRLAFEKKMECLRDDFGSGNRPGFVMCDLNNLKCVNDEFGHDKGDEYI
RAAADAIRTAFPGEAVYRIGGDEFAVYLENKDAETAVEGIARIKTAIEEYSRTQEFHAAI
ASGYAFYTPGRDLEVKDIMTRADAYMYRHKRRMKR
>A0A3S5DPK2|diguanylate cyclase|EC 2.7.7.65|Cedecea lapagei|TrEMBL
MSTSLISHFHLPMVKTLRITHVCFLSLFLLITFLFWQQGELFNHGYRTSQLSNLESVIAR
VESKSEYQMDNLRYLRRLFIETLDEPQFTPLSQLATRARNGASLAPLHIQSLTIPDSIQP
FKNEPQDERDKLTRREYQALREIQDLFPLAGGSDRLASSIYYMSRSGAFIASLSPEVNKR
LIKSANPLAKQGSFVLGSPLLNPRREPFWTRQNDADTGKTLVNGSLPVDFDDRWIGLFGI
VVTAETLRLFLSSALPEDTQSAWMIFDEQMNPITRSVGAQNGYRLSEPQRQEILEQLADE
SRGTLRFGYAYATFGHVTGTGAILVSIQTIRQGLHEDFGRFSVLLVLMWLIVILILIGSH
RMICRLIRNMGLLQQEMHRHALHDDLTGVLNRRGFFETSAGISPRYVDYSLIQLDLDHFK
KVNDRFGHQVGDLVLIHATRCIQQAIRSQDIVGRIGGEEFCVYLPNTDLHAAVAVAQRVR
KMLMNTPLKLEEGSTLLVTASLGVASHEEAPDGSLEQIQSQADIRLYTAKQQGRNRVCWG
GEAEAE
>A0A554WRX1|diguanylate cyclase|EC 2.7.7.65|Tepidimonas aquatica|TrEMBL
MSEALLEQQRLFDVQRELALELQALAQRMQQQVQADQQRALEAQRSAERIVLMLGASLFA
LGVAIGVAVTRLVARAERLLLLDKERAEAAACRDPLTGLYNRHGFEQARELLLRASPNGT
PHSLLLIDRDHFKPVNDTAGHGAGDALLCRLAQLLREQVRSQDIVARLGGDEFAVVLVGL
DAQRATDVGQRIRDAVADFSFAWGGRTFRLGTSIGVATFVAGQAEAAWSQALKAADEACY
KAKRRGRGQVVVGAAAAAEQGWTAPASA
>A0A7R7AG32|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MPSKHLHHKLVIYILCSALFIAGIAISFAFISEFSRSQEHTEVMLNQLMDTVEKTAAIAA
YSRDKVIAKDVIDGLLRNDSVFSASISSDNIILAEKSKTALTKDTSQLARSLHSPFAKQQ
LIGQLIISPNIQFNLMEAKHAAYASAINSLLLITVTTVILLVLVRSNISHPLLTVSNTVH
AIKAGKQNRIPLLESHKHNELGRLIDDINDLLINQEIKFKQEEILRKSMQHMEQQLRHIF
DSSSAGLFLLDNFGHLINYNSTLLTVLHCETKPSLTFTNKDFATLFIKEKREFQLMLSNA
LQSAELQSQDFSLQQHQTPAIWIHCLLSKVIDASGKERIEGVVFDVTKRVLSEQATQHKA
DHDSLTGLLLRQATRERFNHHTTGNDFPKVSVFLLDLDGFKQANDTHGHDVGDIVLRRTA
QRLSACVRVGDLVCRLGGDEFLIIVLDNNTYDGALDIAEKMITNIQSPISINNNLSVQVG
ASIGIAITPQHGLNFDNLVKSADESMYEVKRQGKNGLGIMLANQIQVKLFRPHS
>A0A8F9UQY3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens|TrEMBL
MENQRGKGLSFARRIYRPRIIGLGIGGISVFATLYPLALPGWIWALLLFHGLLWPHLAYQ
LSTRSAFPYQAERRNLLYDSMLGGFWAATMQFNPLPAVTILSMMAMNNVAAGGVRLFIRG
ALAQGIGVLLSWSLFGASFNTRISPLQIYACLPMLTLYPLAVGMVCYRLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLHIKFHKCQQQQIDASIALIDIDHFKAINDTYGHIIGDT
VLRHLSNELRRNLRHDDLAGRYGGDEFCVILPRMDRQQALEVMERLRQVFSQYRHPQVAE
LKVSLSIGLAAFDREFQDPSSWLNAADKALYLAKNSGRNRIASNDDEAHSRQTQMA
>A0A7R6W8U0|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MQAMDIQNVDVLGFHDVLVDLLSSLSAVRALSEIDNLQGISDKQLVREALNVLISNQDME
RCSFFIKTTEDELVNLTGLSSNEALTGQTENYTPLTFKMGEGVIGLAAQSGELQHCTNCV
SDSRFSATQKAFMPGSIISVPVMALGELFGVLNISHPEANHFSDWHIRLLEIYKNMLGQM
LSNFRLFQQMEQQIALKTEHLQKALEEATILKQRFENLSMIDSLTQLYNRRFFYTHASKA
LAMSKRYGDTLCVLLLDLDYFKAVNDSYGHNNGDLVLIDVAKVLTSQMRESDIVARFGGE
EFVVLFRKTDCANGVVFADRIREAIAALQWTFKQQDVSISVSIGMYCMKQDDLQEQGENI
DIFIHYADLAMYKAKSSGKNQVVVFSEDLLQSTEN
>A0A7R6W8S2|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MTDNATHVLAINAAANAILRHKVDSLQVIPAVALKLLRLTNDEKASVNDLSLLIETEPTL
AAKVLRNVNSAAFALAHKITSIKRSVNILGFSAVRQLALNQLFYNKLIRHQANQQFDQLF
FWQHCLFVASLSRSIAIALKHNDPDLIYTAGLIHDIGKIVFEAHGKVSYSDFLESCKNET
QATLLGEHDFFGLNHAEMGYVFCQQWEIPEQIAAIVHCHHNLPNDNSPFAQHKSDIAIVN
FANYIAWMQGIGSITLNNPPELHKDISKHLNIEKLDLEALLNHVDLEMQHTREFYGIQFP
SLNKLRATLVETTLLLSHNSKQSQSNISSSSLTTPHQSLIPDEIVPWTLTAIHADFDFDR
LIMLNINPGKRSLEIAYTLPEPLPEHTLQHFNIRIDLLPRSILNSLRARKAIIVNTKQEH
SSSILQQFKVDEFLIVPVLSHNRLIALLYADNHRKQNELNSNCIEQISPIVHELGVALTN
AKRFELEKKRAELDSLTGLLNKRMMINFLTETFTLEAEQLNQIAVGFIDIDHFKKFNDTC
GHQAGDDVLKIVSQIMRNLTRPMDFIGRYGGEEFVFVLNGTNEQGAYSYAERIRQEIERK
GKILSQRFQGRAFTISIGVSLYKPEFTSYQDMIEAADTAMYTAKHNGRNCVVVI
>Q8EGW1|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MKFFSVFILAILSILCMPLIASTTNYDETLTKIETLQHSDLPAAINLIKTIESEFGAMSR
LQQGRVLLFKGAASIYSGQYQTAIELLGQAEALLKDSEMLFSAYSYEATAYIALRHFNDA
FIAMGKSLGLIERIEDTNLKRASYLRLASLYSAMGISEEVATYATKALALASESDVKDIC
GARLYLSVHQLEIASYAQAFDEFKSTRSYCESSGYPLIANIALKGMGESSLRLNEPQLAI
SYLLDSLKGYESFNFELEINSVHELLSEAYLLLQDSTKAELHAQYVMNLVDDSSNTELKH
GASGVLAKIYAQKQQFEQAYEYSRKEQHYNQLIFDESRMKTLAYQAAKFNADEQAREINL
LNKERELYIAQQMVKEREYTNMLMFITILVGGLFFLAILLVVGNLQKRRFMRMAKMDALT
GVLNRGAGQDLGENMFVQAAARGGDYCVILFDLDHFKRINDSYGHGTGDWALKKVVEVLK
PHIRNGDVFARIGGEEFALFLPYANEAKGLDVAEQCRSRIEAIDTHLSGHKFTITASFGV
SGMTKDDLSLDPLLHRADMALYAAKSNGRNCVSCYQDALMCDKRVTNLTSELARQP
>A8AF72|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)|TrEMBL
MICSTLLTWREVVVLESAYRASQRNHLENVANVLDRQLQFSVDKLLFLRNGMYEALVTPL
DFADLHDAVAQFAQLRGKSFWQLELDRRRTLPLNGVSDAFVNRTTLLSRDNDALANELSA
ALELGYLLRLAHSSTMLAQRTMYVSRSGFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQ
RQNSARGVRWFSSPVPGGEVQQKVTVSLSLDNERHWYGVLAMDIPVSSMKRFLEDAVEKD
SEGEYQLYDYQLRLLATSTPEKRQVNTFDDLELALLANDIEHDTHGGIRMGSRYISWERL
DHFDGVLLRVHTLREGVQGAFGSISIALGLLWALFTMMLLISWVVIRKMVSNMFVLQSSL
QWQAWHDPLTRLYNRGALFERARVLIQRCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDR
VLSHAAGLISGTIRSHDLAGRVGGEEFCIVLPGTTLVQAAQIAERIRQRVNDKEILIAKG
TTLRISASLGVSGAQENGDYDFEQLQSLADRRLYLAKQAGRNQVCVRDDHPAPSPDTR
>A0A5A9CKS8|diguanylate cyclase|EC 2.7.7.65|Citrobacter portucalensis|TrEMBL
MEQVEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIRHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLPQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSHQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTEPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHARKPFSLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAGMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYQAKSNGRDRVEVYQE
>A0A7W3E0N8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00013|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A0T9LDQ1|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MNSYSYDQLLKSKHRLSLLLFLFLNASSAIFSMILPSPETPAVTLPIVMITIISLSAAGY
LVFISKNYVDKLNLFSITMGVLWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPSALTVIFLDDFQNIFRIIFTVMLPLIGFSLHHLMLRRSDDFTRKLVAHLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYATQLAERVRQRVLGLDIPH
VFNHKVSTTVTLSAGISPLQSYDLASSLKAADEALYRAKKDGRNKVAFAKDELSKIESSP
>A0A0T9Q0T5|diguanylate cyclase|EC 2.7.7.65|Yersinia kristensenii|TrEMBL
MLRSMISTKIFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNTLEANRVYAAK
LASSTEIFLRSAQKQLHYSSMIAAKHFDDQGVLKAETARLKYQTDSFNSVVITDAQGIIR
ATSPDSLQLLGHTLTSPGSAEALKLRRPIISKPYVSAANNLVINISTPIITPDGHYRGYI
GGTIYLRKQSILNELLGEHYYRDGSYIVVLDGERRILYHRDVNRIGEILEPKPITEAAKK
NDNGSLMVTSTNGESMLAGYAVVDPSGWEIITLRPESSTLKPLEGLMLKGLGHIAPLALL
TLLGVWLLSRLIARPLWLLAGSANDMDKPDIASSIKEIPSWYFEATQLKRALLIGISLLQ
KKIGKLRFEAHTDPMTGLYNRRGLAMTLEPIAQLGQHFSVIALDIDHFKSINDSYGHDVG
DEVIKQLAIQIRDSSRDSDILCRSGGEEFLMLLPSTVPDVAIQVANRLRHNVEMMAMPGI
RPITISLGVAFWNGVGVPEDALKRADEALYRAKQKGRNRVEVA
>A0A3N6IHY4|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI98-10|TrEMBL
MNSAMRLPGRIGPHALLITAAAVPLTGWALHAVTLYKQIADGRKDLLTGLPCRPDFVAYG
ERLLRTRRRDAVHILMLDGVGFKAVNDTYGHAAGDTVIQTLGRRLARWSSSRTALAARLG
GDEFAVCAVIPPSAALAEITALREHLRQPLQHEEHTLRMDVSIGIARAADLPGEDMSRIL
RGADAAMYRVKKGEATFPYCAMRADAYADTVNGRRAGRRGTHLLAGAA
>A0A1E2RW43|diguanylate cyclase|EC 2.7.7.65|Methyloligella halotolerans|TrEMBL
MAEFLESQLDFIFFFYGLAFILLGAVCFAIRRTDNHAAWMMLGTFGLVHGASEWLDLVAL
ISGDSANFAWFRTAVMVGSYLFLFEFARVVAIESRFRSPGRWIYILLLIPVVIGGWLGGN
AEANACGRYFIGFPAATATAFVFAYHAHHLARRDARLALGAATGFALYGIAAGLIVPAAP
IWPATVANYGWFADLTGLPIQLVRGILACWMSFAIWSIWGQKLIERMASAGYAKHLYRLY
VATLVTLAVILGAGWVLTQYLGNIYKENIEADAEGQVALVKSHLSREMDMLDAMAISLAG
SPTVRTLLTEGGPSAKEEAVSVLALDVQASNAVFGFLMDRAGMVVVSAAGGATAEPPPQI
RMSPIVSRTLLGQTVHQLIYGDDRDQTRYNVSVPVRDDAGAVVGAVVMEKSLDRFASDLA
GLDMPFMLTDRNGIVTLSNNPNMLLKPLWPLSPQREEAAARRYGALNLPPLFKSEIEING
WRELWGARTFVEREPVGHSGWSIVTFTTARGIFASRVLGIIITLMTTATAIVYLMGRERH
IHDQLQMDRQSELEALAKDLSQQASTDALTGLSNRMSFDRRLLLEIARADRYDTPLSLII
FDIDHFKQINDQHGHQVGDTVLTELSGLFAERLRKTDFLARWGGEEFAVIVPHGELEAAV
TLAETLRQAVAEGTFSSGGDVTCSFGVAELEPGDKPETLLARADAALYAAKLNGRNRVEQ
APRSQPASAGLHRVA
>J3SGQ6|diguanylate cyclase|EC 2.7.7.65|Tieghemostelium lacteum|TrEMBL
MESKSISDIVILLFSYLKSNNNYNINNINSISTFNETNNMISELIYQPTAINGANNTFDQ
YQSYYTQQRIRDLIFALMFVIFIIYNLYKRENSNSMVHTFKKILNFTPTLIILEINFKLN
MVKTANPIDIDQSFEYININSNSSQHRNLIPFEQFCEYLQLNASQLSQIIRQSPEQSDRT
FKGLIVKGQGDKKYRITGKFDEKSLVFCGVILDISEEKSELKKMKKMASRDALTGLYNRN
MLNQKIQKFCSQSQSDLCSINFLDLNDFKQINDNYGHEVGDQVLKHLSSQFLLNNMDGSI
LPIRLSGDEFLIVKRGVESVDQANTFINEYISKISSVPFQLSSSEQQKTNLLLKLSFGGV
AFKKSSSSFSESDISAMINTADSKMYEMKKTKLNTYQCNINTVTLYQC
>A0A5H8QJJ7|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASWLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCVVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASLGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A554W6T2|diguanylate cyclase|EC 2.7.7.65|Tepidimonas alkaliphilus|TrEMBL
MMLGPRSLRWRLVAVVLLIHAVMVLALVALLERESRLFAEEQVQRRARTLEVELRAALAA
PIVARDYVTLDEITRELVAVAEVVYLRVEDVDGRELAHATRLNPTDAAPATVRHFTVALG
DARIQLGLDTARASLAWHEFARVAVIWVTLAATAATLLILSAANRLARRIERLSQAAEAW
TRGQWQVQAPARADGDELHRLGRTFNAMAREIAERIQTLERARQETAAALEAVQQERARM
VALLEAMGTGVLLVDRADRVVYLNEALRRMWMIDPQAPVIGERASDLLARSGGRLAQPDH
FSRLVLHVPGTQEVSDSTELTMSDGRIIVQACRPVRDGDERLLGRLWLYEDVTQERRNAE
QLIYLAERDGLTGLYNRRRFEEALERALLDASRRQSRCALMLFDLDEFKHLNDHFGHRAG
DALLVRVANELSTVVRRNEVLARLGGR
>A0A0Q0FEH4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MFETDKWAFSGIDGQISLHKWQKTIDLITGLFSAPSGYIVQATSKGYRVVIRANEGGSHF
ETNPILPPETPLFCKYVAENNKTLYVNNASNDAQWNTMPEVIEDDVESYLGLPIHWPEGE
VFGTLCLKDSKKTSYTDEYFELIEQLRDLIEDDLALIYSFEQMREIAMLDPLTNIYNRRA
LSLLAQHKLNLALRLGFDVCCLFIDINDFKKLNDTYGHDIGDQALIILANTLKAHLREAD
IVGRLGGDEFVAVMQISDRSKLNHIIDKIKIEYANALLENNVCALTLSIGESFTNKQKQP
FDTLLNLADHQMYKNKQAYKLAKKA
>A0A377YUV2|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. pneumoniae|TrEMBL
MVITDPFASRLREHVRATDMAARIGGEEFAVLLEAASIEGAQVWAERFRQDTAATAVVCG
EVSISYSASMGGALLDPRLHSVEQVMLQADSALYQAKKTRVQPSCGRTSISELRGVAMKE
KQADPIKTFRAQWAVMTFYERF
>A0A0Q0FE97|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-25|TrEMBL
MIETVKLTVRLSNFYKMSWVNKAVSIALLLYIITFSLYALNTFPPLNVQNNVYGFTTDFC
NLIVLVFLFWIVQCSELSKQAYVFSTLGLLLWSMGTTADVMDELVVQPYWMSVYFEDLCR
TMGMLFTAYGLFKTMRFVQSIHNRLAHELITDDLTQVHNRRYFYRHVKTAPSTPYVILII
DIDHFKAINDEFGHDEGDLVLQQLATKYNSAFVNNAVFARLGGEEFGGYLPTGNISQASE
FCGQLIDIAHNIKVKQVKQLTVSIGMALQSANEPLDKVMKRADMALYVAKNNGRDQYKIA
P
>A0A7W6GJJ9|diguanylate cyclase|EC 2.7.7.65|Rhizobium azooxidifex|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFDVLTADNGYDALAICERTQVDLILLDVMMPGID
GFEVCERLKESPRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKTLTDELRVRAATAEAIGVETGLGAAIGDEPGSVLLVDGRASSQERIVRALKPIADVT
CMSDPQAALFDAAEHPFELVIVNANFSDYDPLRLCSQLRSLERTRFLPILLIAEQGDDDM
IVRALDLGVTDYLMRPVDANELLARSLTQIRRKRYNDRLRASVKQTIELAVTDGLTGLHN
RRYLDSHLKLLIDRSVARGRQMSICMTDIDRFKLINDTYGHDVGDAVLREFANRLRTAVR
GADLACRYGGEEFVLLMPDTSAETAAAVAERLRMTIEEQPFRISGGGAPLTVTASIGIAS
LLPQGDSPDTLLKRADNALYEAKRAGRNRVVAAAA
>A0A1C4D6L3|diguanylate cyclase|EC 2.7.7.65|Kosakonia oryzendophytica|TrEMBL
MMETYIKTMKGEWEDLLGQTDFHIRRMAAELAKAHAHELSIAFYRIVLADAHAEEFLSNE
QVEKQLKHALELWIVEVLSCQVEDIDRQIQVQQHVAEIHARIGIPVELVEMGFRVLKKLL
YPFIIASSCSAQEKLELYHYSINSIDLAMEIMSRAFSFTESSSAKEDENYRIFSLLENAE
EEKERQIAALLAWEMDMIYKVLLDSDLGNSLPLSQSDFGLWFNHKGRHYFSGIAEVGHIS
RLLQDLDELFRNIGMTPKALRNKPMRIKFLMQIRNTLAQINSLLRELFDEVSRHEVGMDV
LTKLLNRRFLPTIFKREISQANRAGSPLSVLIIDVDKFKQINDTWGHIVGDEILRKVSNA
FYDNVRSCDYVFRYGGDEFVIVLTEASEVDTLRIAERIRTRVEKTNIKSPTGENIALSLS
IGAAMFSGHPDYERLIQAADEALYIAKKRGRNCVELWKAAP
>A0A1E8F0Y4|diguanylate cyclase|EC 2.7.7.65|Clostridium acetireducens DSM 10703|TrEMBL
MDKKTLIKILKQKDDILKTLCLEKEKLNYYANIDGMTRVLNRRAGLKLLNKELNWSKTNE
KNLVICFVDVDRLKMINDNFGHEEGDKTLIFVAKILRESIRKTDFVIRMGGDEFLVVFPG
TTMKEADKVWYRISRKIKAINNNNNKYNLSLSHGFYEYSKEIQREMSINELIQKADKEMY
KKKMKKRRNLLTCV
>A0A7S4H1Q0|diguanylate cyclase|EC 2.7.7.65|Serratia sp. Tan611|TrEMBL
MKVKYLIYFFTFLLTASFTISICDEWSEAKEQYNDSAWNLSKTQHSEDVSGAFQNSLRLH
RIKRLSLVNPALEPALWQETERQTRNKIQQIRRYADSDARQQLTTQQKIDIRSMLNLLEK
MLNNDTQQLAPMNNQIRNLFNINSAYYITQSSMDYYSYTYESRILNADAFLFLESIRLNN
QLNITLTEIIDQLVDIKLNGLNDKESYLKTIQLTGVLNVLSSRLLFMEMVYSDPQVSRII
NQLLENLSPQQTNGLAGELYASMAHGKELDATRIYAYVKELDRLSQQFFQRSFDLEIEKC
RKKMYQSQTAINGLIAFAGLLALFLLMPTLIFCSNISRWLTKTQGNIQHLSQGNMAIDAP
EVFYSQELIAITDAINQLKQYHLEKVRLEQEKHALIKELESSSYLDPLTNIYNRRRFFRE
AEQLPAAGYPLAFCLIDIDNFKALNDTYGHNIGDLALVAFADLMRHAFRAEDIFCRYGGE
EFAILLHHCALPDARAVLEKLRHRVQRLRLPVPDGQPVRFTISCGIAAVASPHQLQSAIK
LADEALYFCKKNGKDRVAINTGSGCR
>A0A7X0AWS9|diguanylate cyclase|EC 2.7.7.65|Nitrospirillum iridis|TrEMBL
MSARVLVVDDVLPNVKLLAAKLTREYFDVITASSGPEALDKIKAQAPDIVLLDVMMPGMD
GFEVCERIRSDPAIMHIPVVMVTALSDIADRVRGLEAGADDFLTKPVNDVALFARVRSLV
RLKMMMDEWRLRESTSGQLGMLVSTDSMHNQSAEGANVLVVEDSSIDLDKITETLGRDRG
RVASADTCASGLERALAGDFDFIVISLTLMREDGLRLCSQLRSQEKTRQVPVLLVADETD
IDRVAKGLELGANDYLIKPIDRNELMARARTQIRRKRYQDRLRANYEQSLSLALTDSLTG
LFNRRYLSAHLPRLLDRGGDNHKPVAALLFDIDHFKVVNDTYGHGVGDEVLKEVALRASR
NLRNFDLVARLGGEEFVVVMPDTDLAAGVLVADRLRRRIAEHPFHVTTDGGQITVTISVG
VAVAAGAVGPEGRMETGDSLLRRADMALYEAKRAGRNRVVTDSSLEAAPPVRVDATDLSL
PR
>H6RK93|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MTTSATTAPATARAAWLHAALVVLVVAVVVTVVPLGPWRPAAEVVPFLQGLAGVVCALRR
HGAPLTLTWRAVGVALLCFAASSAVEAPEMAGVLPDALGAVESVLDVAAYAALVVAAVGV
LRAGRRRRDWAALADTATLLLAAGLAVLAVSGDRHGMSTDLVEVGIGTPLLTAVLLLVCV
PLAMSRGRRSVSTMAMLVAAVLTVIGYGGRMLVGPLRESPLLDPLPLLAVAAITLATRHP
SVAWMGLGPESDQDAASGRVLGLGAALLISPALLLLWSIGHGGVGYVLGAGSSLLTGLAL
WRLTALNRERERVRAALVASESRMQLLLANAADVIAIIDNTGAISYMSPAAGSLLGRSGS
EYIGRAAIELADPRDQARLRAAVAEAGAAGTEVTGFVDTDIRIAHGAGGSRWVEARISGK
VDAVGLHGWVVNLREVTDRKLFEQELRRQATTDPLTGLLNRASFNERLAEATAAIDTGSS
PAVLFVDIDDFKSVNDTLGHAAGDELLLTVAARLSADVRGGDVVARLGGDEFALLLADAD
DGRLRDVADRLLAALREPVELAGRTVTVTASIGGALAEPGCTAERLLHDADTAMYAAKRA
GKDSRALPGPPRPRSPEPTAAPQPR
>N9NJC0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. CIP 101934|TrEMBL
MDMLAGQWQHICQNYSSDDLVHAFQFIQDNALILVEEFYKNMLVEKESAEFFSDDLIQQR
LRNTLHQWLLESFSVGINKHYLQAVQKQHTVGHVHARVGIPSWLIMRGVREIERKIFELL
EEDEQLLTLTTCSYLVQVMSFATEIMCRSYEAKTAKNQEIKHSYRLFSAMQDVAVQKDKQ
RSCLLDWENELMYKVFSGQETLRHPLLSKSEFGLWFIHKASYAFTGSDQVQLIIERIHQV
DTLNQIILECQDKTKKLNLIQQIRELNREIQHLIDQLFQVAEYIESGNDSLTQLLNRRYL
NTIISREITYSRQNQTPLALLALDADFFKTINDKFGHAAGDLALKFIADGLQKYSQGSDY
AFRVGGEEFLLLLVDTDQRRAMNIAKNIRKFIEEGIITTAQGIQFKFTVSIGCVIYDGHP
DYQKFLDTADTALYAAKNTGRNRVYLAKNDPDTRVLNTPSLT
>A0A6D1SF71|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MSDFILARVSQTLANEHSLELLVRQLLEMLELVTRMESTYLTRIDLSAQRQLVMYAHNSS
EMTIPEGFSVPWNESLCKRAIDDNCLFSNDVASRWRSCIAAQELGITTFFSIPVRLTDGS
LYGTLCATSRQKQPYNLEGEQVMGLFANLISHYVEKETLVEQLRAANSALELHSYTDELT
GLPNRRALFKHLSTMFPRARELQRNILLIFIDLDDFKAINDRFGHPCGDSFLVQVGERLN
ARVRQGDLVGRLGGDEFLIIGAGLEAEEQQAFIAALRKELGGIYFLAEHRISYPGASFGV
IDVDPQTMDMESALRAADDAMYQDKKSRRKETFLDID
>A0A4U9D5D1|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MKDESKKYIAVIFKEWLPLHDSLTPEVKAVLNNIAAEQAEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAGWVKDILTCEKDGLQALAERQYHIGSIHSRIGIPAEAVLRGARQLK
AGVIEYIRDSAIDRQTGVAAIYYAIMAFNMAIEMMCHAYTLSHYRATKTKRPIACTA
>A0A7Y6NGA3|diguanylate cyclase|EC 2.7.7.65|Pantoea brenneri|TrEMBL
MTIEIPYLHNRPNKRWISALFLGCSMFVLTLFCLELIVVSGKISPLWFPTAAMTVVVFRC
PSRQLPLYLAACVLGTACANAIIIGPALSNIKFALLNLLQAGLGGILLRALLDRRAPLSS
LHDWARLVLSVGIVTPVIGGLMALWVLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPVRRTQLRELRLTEFFLTLAVTLVASYLALRYLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFMSMLLALGLVSVVNNNSALGPVSSWLPFLLVLIPSHIMSLVMDAFRREKNHIS
ESETRFRHAMEYSAIGMALVSPQGGWLQVNHSLCQTLGYPEEELRRLTFQQITHPDDLSN
DLQQLSKLLSGEIYTYTLEKRYFRKDGEIVWTRLTVSLVRDPAHLPLYLIAQIVDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWIHL
LHAGDREHAALTVQQAIELRSAFHMEYRIVNDDGQRWVRTQANRILSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDEAMRVAFMNPVAEKMSGWSQQQAAGK
PLSELLHITQGRNGPEIDTLLLCQLPREKITPDLDQDLVLHTPDDGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRQLMKRLSYSALHDTLTRLPNRASFEHQLKRLLYDAAEHQHHH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMLHHLRSSDFLARLGGDEFALLMPDCQV
EQACEVIQRIVTTVNDYRFQWLGRLYQVGASVGVTQISPDNCQSSDVLSQADIACYNAKR
SGRGRYVVYEQHRLPLAGNHQGLDAAMIDSLQIELPAWAVAPPNTPQSAFLWLLEVQLLT
PDGLLIDETLLRNNLPDEGLRRQLDNKILEAFFQHDVQGLNEKGIAVVLPLSAQALLDAD
FVQQLCRRFVTAGLSDSRCGFAFPAASVLTQGDRLHSALLQLRQSGCRIVLQHFGRNLDA
FNQLSDEWVDCLVLAPELVSNVHNNLMDEMLLTIIQGQASQRNIALLAGPVSVPAVLTTL
ASLDVDGVWGSAVAERQPLSVLAEARFFAIR
>A0A517WGX8|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MRVSVTFRIVAGLVILTLSTMLIACSLNLAPNLSRLQMEDRARYCEVLAVSSSLFLTQGN
SEALQDYLAAVVKQNPDISSAVLRKQDGEVFLQAGPTVNLADADLASKFNQVRIELREQN
LLWGQLEIYYPVKQAGLLSLWHRPMTRYIVFVAGCCFLLFALFLRKTLQSLNPSRVIPGR
VQEALDTLAGGLLILDTKEQIVLANKTIARALRTTPEQLQGQPVGKLPWMIQSETEAESE
SILPWTRVLTDGATHKGITLSLESNTTIADCFVVSCAPVLDDEGRSRGVLVSFEDVTELE
KKKSELREMLQALHESREEIQQKNQELEYLATRDPLTSCLNRRSFYEQMETLWAEAKEQG
TPLGCVLLDIDHFKSINDNHGHSTGDLVLKGIGATLMELVTAPGVLCRYGGEEFCILLPE
HDIDQTAQVAEEYRRAVERLEFEELKVTSSFGATAVSLGAENAQDLLDEADKCLYAAKRG
GRNQVSRWDLVPRDMDFSEPVAREPAPVGQTPVSQGPAVQEPAISSEAALRLGQTMDGLG
QMIDRQDFDGLAKLADEIHTLAAAQNLPEVAAAAGQLRDAATTMDVVEAIYLTNQLMEQC
REYQSQLIATVAD
>A0A1S8MBX3|diguanylate cyclase|EC 2.7.7.65|Clostridium roseum|TrEMBL
MNIINNRYRIINTIDKKQIFSSFEVTDILRNDSNLKLNIIELRNIPNNTKNHIKNEFINL
VNLNENYIYKLYSLNVISTIDNKTEDDKRWYYTCEICKESSRLVEVIDNLEENDIIDIFV
QICIAIQYLNNSGYAYRNINSKNIYIKRQNGKVNIKLNDLISSELEKIKENYAGKREWFQ
FDFKLDYGEKYSEIVSNEIRDLGILLFELCKSKFSSNTKINNSLELQHNVNKAVTIKNPH
KEFEMKIIPIINKMICNTSERYTNIKAIVEDINIVFSRRYNIYDVKAFEKLNYNVKIVGR
DGPINKVLNLCSIFKNVVNKSNLFIVHGKSGIGKTRFLKEIRYFFKFNMDNVYCSFGNRD
NITRNIFDEILKQILTSYDTRIIKSYEREIGKKIINKLKDSKNITTEEEKIDLFDKCINF
MNVMASKKRLVIIVDNVDKVDELSTDFIKYFYEKVRNTKNIVFMFSYLDEIIYTNNDVGQ
FISSFKVNFTDIILNELNFVSTNELIKEVLGTSILPRDFSKKIFEKTKGNPGFIIEVLKG
LYVRKYIYVSKDNGLWVTSYDKINEIPIHSSLVKNIQNQINDMCGFELEIVNAMCIFNIG
LKLETIKMFFKEYDGENIEEIIRKLLKRGIIEAIEEDSDTYYAIANKTIKAALTDRMDEE
YKSSINERAAEVLEKSNPSKYKEEILFHFEKSLNVKKIIEYYLNKYQYPIYIKNKREVVS
KIKKLVKTIRNNTTLSGIKLLIILGDLLFLDEKDREAQEYYKLSEKLLHERKEYEIQFQV
LKRLVRMLQNNSQLKESRIYIYRQEELLRNWYNLELELLIYTEEAFNFYLTKEFERAISI
CNNVIDKCTHDMEDVKFYAYYVLSNSYIEKGDMKQAEKYSKMCSDKRYLKDNLPYVLDSL
NNIAYIYGNYYEEYLQCKNYLFRVFQIATHFNYSHFKLLSLSQIATLDFKQGSYKEAYNG
FENVLGLSEKINDKYIELYCYCRLCKVCLVMYDIEEAYEYFLKASTRIDDLKNYLDLMGV
YYSAAVEIYLKMGMPEKAKEYMKEFKDKCGSQNIKKIDEVVGYYIDYLIDSNETAITTFR
KALSGMDFTNKNVNSIVIIVQIAIIVYWKKDLEMFNDIYIMLSRCNIKNKLVRDCIGIIR
TLNLSNEEMLKYAINTLRKCENDIKISKFLYVNICNYYLKSGSYIRAINYCFEYIDFMWN
YYLKVPDKYKENFVRCYKIKNDLREYIDIINNYMGQKIVDEKSVEGILSKEGIEKFYENT
DLKKLFYTKQLKKDLKKYYFSFIPRKVNSRINVMRNQVESSVINIQNILKYLKYSLIAKK
IYFIVMPTQTEDTVVFTHNQNFVDNNIIKENTIIYNVSSKRNPIFIKRVGLKPNMELEEN
IKAVICIPVYTVLSNLNKRNNKEITGILYIESDKILNNFNVNAINKCIEFNGLISLNVDK
YRLKMSSTIDVLTGTMTRRHLEIYMDDLLDENRNFIKEFTVLMYDLDNFKAINDKFGHGT
GDLVLKEVSKIVMNNIEEKSVCARYGGEEFIVILPNHNVLKAYEVADKIRRRIDKAKILG
NKRSVTISIGLVAYPDMAISKEEIFEKVDKALYIAKNTGRNKCVIWNERFNYKARATNKI
TGIVTGNPVKDSRNVLVTVEFIEMLKSSISTEEKIFNALGRLVEFFEATYCTIILLKDKK
VSNVYTRKIFKSDFIKKTYINDKIVREVLEKKIGVYMIDWDNISGFDETTGMPDWDSIMV
IPLINKGIINGILYFKVPAKIKEFNFEEFNFASAISNIVAALF
>A0A517WN07|diguanylate cyclase|EC 2.7.7.65|Gimesia chilikensis|TrEMBL
MRNYYTAIQFWSYSLLVVCLCPLAVFLGAYMHWPLGVAPLLLLAPPTVLAAVSSPRVCYW
TITVLSISSCFAEIFFRPDLEEVRSTYPASIMCASVLVGLVLLIDLYMGKLRHKLSQMHD
QNDELVRQLYQTQKQAAVDASKSGITEISEKPVSEQKENTSVESGVNYPLLLLTLQDIGR
RISTNQSNESLIPTVISTAKASLQCESCQVYLWDTKSRALKNALPARARDRLDYRPAANH
GVAAWVIEHRQIVMRNDADQDYRLKRIIEDDPNMPDAIAPLTVGSEMIGLLIIDKIDVDS
PTIGRLIYILSNIYALGIKNSQLFKRIEEMASRDGLTGLYNHATFQEKLHELVKGAEAQS
TNLSIIMSDIDHFKSFNDTYGHQAGDFVLKEVARIWKTVMPDNAVLARYGGEEFIGVLLD
HEYSQARQIAEDLRETLENCPILFEGQQLQVTASFGVTEFRHPATNTKDLVRVADEYLYK
AKEGGRNQVVGLDTNATRKPGT
>A0A7W6WWZ9|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium sp. cir1|TrEMBL
MSARILVVDDVPANVKLLEARLSAEYFDVMTASNGTEALAISRRAECDIILLDVMMPDMD
GFEVCRRLKTDPATHHIPVVMVTALDSPSDRNRGLEAGADDFLTKPVSDVVLIARVRSLT
RLKMMTDELRMRAITSLEIGMQAPERTAVADTGKGGRILLVDDRESSYERLATILAAEHT
VDVEPNPTEALFHAAEGNYDLLIVSLDLNNFDGLRLCSQARSLERTRHVPILAIADAENS
TRLLRGLEIGVNDYLLRPIDKTELLARARTQIRRRRYTDHLRDNVQNSIEMAITDALTGL
HNRRYMESHLATLAEQAATRGKPLALMILDIDYFKSINDNYGHDAGDDVLREFAVRVRKS
IRGIDLACRYGGEEFVIVMPETDLHVAGMVAERLRRSIAGEPFAIHKGTKRIEVTISIGL
TTLEQKGEAVADVLKRADTALYRAKHDGRNRVVSQAA
>E9XIP2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TW10509|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDDHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEVTAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRQRAVRWFTSQSEHASNTEPQVTV
SVPVDSNNYWYGVLGMNIPVRTMQQFLQNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTHLYNRGALFEKARQLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRALDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSSTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>Q88GL0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)|TrEMBL
MSLAANPDIMYRLLIQSVVDYAIYLLTPEGIVANWNPGAQRAKGYRAEEIVGQHYSLFYT
DAERAAGLPAFNLEQARSTGRFEETGARLRKDGTAFHAHVVIEAVYDDAGQLVGFAKVTR
DISERHRQELELLQAKELAEQYSQEMAKLSQFLDSVIANIPASVIVQDLESQRILLANQQ
AERLFGGPQHSMIGQLPRECLAPAAGDYLEQQFVRGARSTKGHAAETRVDTARGPRTLRS
RTLLSQNREGQADYVLFVAEDATEELAAHAQIHHMAHHDALTGLPNRTLFHERLRQALLR
GSENAKLTAALCLDLDNFKNINDSLGHAFGDKLLRELGKRLRRELREHDTLARLGGDEFA
VVLTGLEGRDAACNTAQRLIKAISPPFRIEGHQFAVGVSIGIAIAPDDHDQAEQLLGYAD
MALYQAKRNGRNRYECFDVELDVAARQRRLVETDLRTALHLGQLQLHYQPVVDHQTSSVT
GYEALLRWEHPTRGMVMPMDFIF
>A0A1V5PVL6|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MASGEYISYESNDHQGKLRIRQIGDDFFGEAVENIKKIVHKSDRDMIVDFFQKDHLLSVF
ESKKATSIDYRLIHDGVPQYYRLIVRKASDNAHFILCIENINDEITKEKNALRALNNEKK
LARRDELTGVKNKTAYKELERSVQANIDNGMDYLPFALLVADANNLKKINDTEGHVAGDE
YIKASANLLKEIFSNSPVFRVGGDEFVVFLRADDYIERKVLVDKLHNVVLENQKNDSGPV
LAAGMSEFIPGEDSLVTDIFDRADRNMYENKQKLKERLSI
>A0A2N9NX37|diguanylate cyclase|EC 2.7.7.65|Verrucomicrobia bacterium|TrEMBL
MDRVLLQVKKRKDRHRLEEWLSKSYHVLLPDHEHPLKEEMDLVVIDGPSLKNLRPKVRAR
RKAEQPVFLPFLLLTVRRRGSMPARHLGRVVDDIIVRPLNEQELLARVANLLRMRHWSLE
LKKEHDRVMKLAVTDDVSGFNNTRYLHRYLDRLIEAAALKPVEVCLVFFDLDNFKQVVDG
HGHVLGAKALREVAQTVHNALGPDDRLVRYGGDEFIVILPRQSKQEALVKVARLRQAIAK
TPFLHKEGIDARLTASFGLAAFPHDAKDKRELLAEADRCLFESKSAGKNRITFAELEKAA
>A0A1C7FG09|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MFARALLKNIMSARNHRFLAHSLFQYIDELLEPQSASIVSEPHSSEQPLSLYEQGDPTTL
NNYPDTFWSWVAQFDTSDGLIPLAMATCQWEGNSIINHDSYIFMIDNFSEARTYLILENV
EADKMQQASLENSLDLLQVIASRWQCVRAELEAASEYKQRDIKEAKYLDVIQQREKFIED
MKLVQRISVEISNPETIDDLHRIAVEAIREQLGFDRAAFMLLDIKKRCFSGTFGTDENGK
TVELQHTQYDLHQLEEAYINALFEGQDGLVVLEDAPLYNDGAVIGQGWNGMLILRDGDDI
IGWVALDNYINRSPITSYQKQMLESFGSLLAQIYIRKRQEQNVRMLHASMVELSRCMTVR
DVCKSAVTFGINRLGIDRLAVFLTDENCSYMQGTWGTDIQGNVVDESYYRSELVDRSIVN
NARSNPNEVVFEESVPIYHDYHIVGFGWTAMTMLTSSSGEPVAFIAADNLIRRIPLTHQQ
REMIRMFASNLTEVLSRTRAQEAVHVLNETLEQEVKERTKELQKANEQLELMAKMDPLTR
LGNRRMLESLLEDICVDDKGRGATYGLILVDIDHFGLYNNYYGHMQGDIALMRVGSILQY
HAQLSNEVFCRIGGEEFALLVVNQNEQQVVALAERIRSSIEEEAIPHADNEGRSVLTVSV
GYTVTSVAGDEFNFDALYGQADQALYQAKGSGRNIIRGYKMPLEAVE
>A0A5E4VLA8|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MRIRHWLYAACVAVGVLVACWVAADRTATSLVGDKLAQSVAAEQTVADRVADGMIHAINT
DLSMVRAIPSTLAEVDLLRDVLSPANGPTSAPEVVARANDFLQSAQGYFGVDRVWVIDTR
GVCVAASNFRDSPSPVGQTAAGMPYFTNAILGARFESYAAGWEHQAPGLYFSAPVYREGI
LIGVVMTKIGLARLRHWVANGESFITDGNGVVIMANDPRFENRFMLDGKLGGLSEPERQA
LYQRNDFSRMPIFPFKRAPGRANAWVPQELLDQMSEFDEFHKPFVITTRASSSNDLTVYA
VENVGAWESLTRQHAKDFALCFLLYLGGVIILMMAGRIYWRERTLHRQTRQSNEELRAAN
NQLAFEASYDELTGSLTRRYFFHRFDQLLEAAQRKNEPMSLIVADLDHFKSINDTYGHAI
GDQVLCRFVLVCSSTLRGDDLIGRIGGEEFAILLPGASERDALRVADRIRERCKRESLEG
SEPPLRFSASFGITEWQDEDSPMNMVERADMALYRAKRAGRDRCWVF
>A0A1E3WGQ9|diguanylate cyclase|EC 2.7.7.65|Vibrio scophthalmi|TrEMBL
MLQGVILLLYSERFPDRLMWIFPIIAATILINEFRTGLLFSVSFCALAIAASLFTDAVFT
QLDTSHERFILSLVVICLICNTASFYYSKMLNYIQSLYREGIEDLAYLDQLTGLANRWSF
EHWATKKLAEIIHLPSTTALVFLDIDDFKEINDTYGHEVGDRVLQQFSKRLKNNIRTRDR
DSNKHDYSIARFAGDEFVILLYDVRSKQDLEGILHRICHLFQDSYSGSKQVSSLTVSVGV
ALYPQDADNLHELTRCADKAMYAAKHKGKNQFQYYHGDTLCSLQEIPTLTEGNVRKLNNA
>A0A3N6GZQ7|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. ADI98-12|TrEMBL
MTPVLRAQARIGQRALLLTTAALPLTGWAVHAAVLHTQLAATRRDPLTGLLRRDAYTTRA
RRILARHRNDSAVIMVDADHFKAVNDTAGHAAGDAVLAAFGTRLTAWAGPRAAAGRLGGD
EFAVVLELPADRRQQRLNQLVRMLHTPVTLDDGRTLDVAASVGAATPDVVGTRDLTALQR
AADAALYDGKHSGRAHLATAAHTAAPSVNGRRSGRPGTAAWGRAA
>A0A8F6DIP7|diguanylate cyclase|EC 2.7.7.65|Sphingosinicellaceae bacterium|TrEMBL
MSRFRSLAVRIYGVAALTAAAALLFGLVLLQSSSRSQEAFGWVKHTQEVIVSLDTVESRL
SRAESALRGYLMTRDESYLAGFTTDVAEANALTAKLTELVVDNPVQEARALQLASVAAEK
GRVMAAAAQRMRASPLGTLPDARERMRGRNMMTGITRQVGAMRDQERGLLAVRTGNAETE
AHQARALLLYGSPFLALLIASIAWLIRTSISRPLANLLDVVTRFGAGERTARAATSAGSI
EFRELAAAYNDMADRLVVALDKQEVRQHSAHVLHEMAQRLQAIQVDGELAEVLDCFMPQL
LPDIAGVLYVHNHSRNMLLRVASWGDPQASPEMFPPNDCWGLRRGQTHIVETPGADLVCA
HATEPAVERRCEPMLAGGEVLGLLYIEGHIAGENDFRLGMLMENVALALVNDNLRSRLRE
QSIRDPLTKLFNRRYMEEALALETARAERSGVPLSIVMCDIDHFKRFNDGHGHEAGDLLL
AAVAGLIQSHFRLGDIVCRYGGEEFTVIAPGASVALIHSRAEALRIAVRELTVDHQGHRL
GPVSMSFGIDSWSADGDRVLSELLVEADRALFKAKRLGRDRVEFASPIAAAGLATTTAPV
LQFQSFG
>A0A381I7U3|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNLKKLLLLIIVITSIFTSCIFSFGINAIGNDNRTIRVAYPIQKGLTEIDEQGNYFGYTY
EYLLEIAQYTGWNYEFVQVPGEINESITKLMKMLENGEIDIMGGMLYNEPMQKIYNYAGN
SYGVANTVLQALYENTDIDNIMSSQDVKKIRIAVIENSDTRLKELDEYCKMNLMSPELVY
CKTNDEQLEALKSGKADVLLNVSMNPIEGVRTVAKFSSKPFYFITPKGSTNLTQKLNSAI
NNIEQKDPYFSTTLYEKYFTPENNQMFLSDEETNYIKETEKLKVGVLLNKPPFQNIDKDT
GELRGISIDLLNHICDKTGLEFELVPVKSQEDLENMTKKREIDIVAGMIYDYEYSREHNI
AMSRPFLSTQYTMMINNKLNENSLNGKRIALTKGVNYYGQFEENIVWYDNLEECIEAVNK
GYADYTYGEGYSMQYYMNQPKYKNVRLVPQTYKAKSICFGIIKKDKQELLNIFNKAIISI
SSEKMQSIVYQNTTYRQDFSLLYIMQQNPIETIFIVASLLICIIGFMAFGLHTRTSMNEK
ISLELKKHTQLYEMTSEYFFEYDYKQDKLIISMPEKGIETYYGLDKNDKESENGNIENER
DKIRKEYNKKFFDVIKSQENGTTEMYSIMLDDTFHWIRVTSKIIYNDRKIPMYVIGKICN
IDSEKEEKNRLLDKAQRDSLTNIYNAAYIRKLTAQNLLNLSTEKNGALLIIDIDYFKSIN
DTYGHLLGDKVLIDVAKVLDESFAKNDIVGRLGGDEFSVYINDIINKEELINKCNDVYNH
IHLIKLPNGESFIY
>A0A8F5IHC4|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. NLF-1-9|TrEMBL
MADAGAHALNPSAGELRWLALVWLLVGLLLAGVLWLAQGRVQEREGALLAQQARVLSSLL
AQQIVTLDGMLAVLADAPEHTREEAATGSGWLLRQVQAQARLAGGLMAVLDGQGVVLAAS
DGALIGTRRDGEPFFEPLRRAPSARTLYLGPPHRQGLTGGALMLSRAIVSPEAQLLGVVS
AALDLSLLKRSFADVRMAPDAVAQLIYGEQAMLIPLGDDGAGAALDPTAQGMALMRHRAL
GVPASVQQVAVHGQSPELVAAVQSLSLPGVVTDRPLTLSVARSTRAIMDNWHALARALAL
LYLLGTLAALGGLVWVRRRRRSRQAQRRDEKQELQSLQARWSAVLHATHMGIWDWDQRTR
RMYYSPAVQTMLGYGEDEFGSSWHAWESLLHPDDRADLLQRLRQFVAQREEVFFESVHRM
RRKDGSYQWVEVRGRVVEREDSGRPLRVAGVQSDISQRRALETRLERLSAGVPGALFEYR
RDPSGRDSFPFCTDKIRELLELTPEQLRQSAGHLLKRVHPQDVAPLLRSLLVSVQNLTAW
RHSYRVVLPGGAVRWVSGMSQPRRADDGATLWSGYLWDTTAEHALRERLDMLVENVPGLL
YQSRLEPDGRTYFTYASKGAIALYGVTPEQMCSDAQSVFERFERADFDSGMQKLAACARD
LTLWSHDYRVKLPGQPQRWVRAQARPQRLPGGAVQWHGYAQDVTEARAQATRLQEAQQLL
DHLMREMPVALCMVDQDGLFYYRNRAFEQYFGYGPDEVITRERWWHEVYPDEDYRAQMWQ
QWNDAKANAPQHGGRILPGDARMWTRSSGQRIMSVSGMAFGEHYLLAFVDRTEQHAHSEM
LREMAYIDALTGVANRRQLDLTLKAEWGRCQRGAQSLALLMIDIDLFKAFNDLYGHQEGD
ECLVAVAGALRAGLSRAHDLVGRYGGEEFLCVLPMCDLDGGLRKAEALRQAVQDLAVVHE
GSNVAGVVTVSIGVAALVPDELGDAQRLVALADRALYLAKQRGRNQVAANE
>A0A329HNU4|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. RIT 418|TrEMBL
MQRDTYDVKRTVLQWLRKRSNPGLIVNLCFLVVLIFSTLLTWREVVVLEGAYVSSQRNHL
ETVASSLDRQLQFSVDKLLFFRKSMGEALQTPLAFAVLQDAVSRFNLVRTRASWQLAVDK
NRTLPINGVSDAFVSKTTLLNRDDARIDREISAALEVGYLLRLASSAVKKEARGMYVSRA
GFWLATDTPAKNADAVSRYYQFVTQPWFTLQSERENRARAVRWFFASSTQHAGTITASVP
VYFDNYWYGVVAMDFSNDTIRRLLVDAVDDRTEGEYQLYDTRLSLIASSAPSADSINPFD
AAELAQIAHAIESDTEGGVRLGSRFVSWERLDHFDGVMLRVHTLDEGVRGDFGSISIVLA
LLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFEQAKILGEKC
QKQSRPFSVIQIDLDHFKGINDRFGHQAGDKVLSHAAGIIASGLRDNDVAGRVGGEEFCV
VLPGIALAEAAAIAERIRMRIDAKEILVKKSTTIRISASFGVSCAHEKGNYSFEQLQSIA
DDRLYQAKQRGRNRVVWRDEGKA
>A0A508T2N4|diguanylate cyclase|EC 2.7.7.65|Bradyrhizobium ivorense|TrEMBL
MLHEPPNALRLITQAYTSLLIIGFALLPTQFIAYLYFQQDPALKFEDHLFHEFAIAVATL
EGLFVTYVTWRCYRSSGEPLLRWLTLGFLAFVLIYTLHGAFTGMAHRNIWLFLLYGPASR
LAMSILLFVGLLSYNRPSDGLEKRSDTRAWLMWIGLFLTMDLAVAMVAYSPYAGHPVVRL
SMEGGALLFSALNVAVLLMRRIHSPLMLVFGVSVAWFALSSLAFILAAPWNHMWWLAHAI
FAGGFFLLSYGVVQAFRTTQSFATIYSQEEMTARLAESMADTQKALQQVQLSNQRLERLA
ATDPLTGAGNRRHFIEHIGAEIARAKRTGAPLSLLSLDLDHFKGINDSRGHSVGDEVLRV
FVRKCLEAIRPYDSVARVGGEEFMVLLPGATLDAACAVAERLRSAIERTAFDVGAEPSIG
VTISVGVSEFGRDGNTLDGFLNVADQRLYRAKFEGRNRVVVA
>H8FVK5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum molischianum DSM 120|TrEMBL
MFGGSGNHSRSEETNLVAALNKAVFDSVADGILSLDQEGRITFVNRAAEHLSGWSERETL
GLAGEAVFPFVSLLPQQGRVVARERVEAVLRGRDGLSIPIEIVAAPIVEARRVTGSVVVF
RDIRERRHAEESRKLAAAVVEWSPQAIIVADLSGTIIIVNPAFSRLSGYEAADIIGRPVS
VLRSSHHDSAFHAAIRRALDREGIWCGEVWNRHKDGTPYAVWLSITRVVAEAGGGGFLVG
FYFDITERKRHEERILREAKHDPLTGLPNRRMFEETLQAILTQERGEGHRVAVLLIDLDG
FKAVNDTRGHDAGDALLCEMARRMAAAVRVDDMVARLGGDEFVIVLAPVESDGVARRVAA
HLVEQLSRPMAFDGGPLKVSASIGIALGGDGSEAADLLKRADTAMYAVKRAGKHGFQINS
SD
>A0A2Z4UGY1|diguanylate cyclase|EC 2.7.7.65|Rhodobiaceae bacterium|TrEMBL
MTSTANTSPALEYGAKAMQLMGDNSIEPTPGAYGVWYAYASGENPEINTKINDRFEASKP
FDSPFMYELESLLSAPEEQLTDSTIEAGEQLSGKMDNVIELIASVTGDTNRFGKSMQGVS
DALTSEISAADLGQVVETIVAATKQMETRSRELEEKLTESKSEVEELRSNLAQARSEALT
DQLTGIANRKAFDEVLLSSIAEASQNGSEMCLAMADIDFFKKFNDTFGHQAGDQVLRLVG
RCLSNNVKGQDTPARYGGEEFAMILPNTALDDAIKLANHIRETVKSRELVKKSTGENLGR
VTMSLGVAQFGMGDTPQTMIARADAALYEAKEQGRNRVVAADSAAAAEPAQAAS
>A0A1N5RHD6|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. bolletii|TrEMBL
MTYGESVAYVVYCDVAILIGICVVTTTGVAFVKLAWLLAVSAYVSLVHGRVAVAMQSLVT
TAGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAGLVIYVGKAQFSEHADGRDRLARH
DVLTGLLNRRGLQEAYEATVGVPGMHVTVVVVDLNLFKQINDTFGHHVGDQVLQRTAHRL
RSVVGPDALLARLGGDEFGIVVVGDAPPDIDYQRAVEEALNSASEDVPVSASVGVAAAIL
PESDRTTIHTLGPIVTHLLVEADGAMYGAKKAG
>A0A854M391|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIQELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKAIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFAFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSQLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDISDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTLIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A849NVD4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter indicus|TrEMBL
MNQERIEELAAQWQAICGQFSETDLSYSFEFIQQHVTVLVAEFYRQMMQEQEASYFLSDE
LVRSRLKNALQQWLLDSFAVPFKQDFKTIVAKQLKVGEVHARIGVPSWLIIRGIREIQRK
SFVFFLQTPQADVLAAADYMTQVLSLAAEIMCRTYEAKVEIHNDMKHTYRLFSAMQDVAV
QKDRQRGCLLDWENELMFKAFSDQSPLFHPPLSKSEFGLWFIHKAAYAFASAEQVEFIIQ
RIYQVDQLNQQLLDTSDQQQMLLLIQQIRCKNREIQHLVDQLFQVAEYIGTGNDSLTQLL
NRRYLNTILIREIQFSRKNRSPLSLLAIDADFFKEINDRYGHAAGDLALQFMAEVLLESS
KGSDYAFRVGGEEFLLLLVDSDWNRAQMIAETIRRRVEDTPIRSAEGESFKFTVSIGAVQ
YDGHPDYQRFLDAADAALYSAKNAGRNQVYLAK
>A0A7R6VBX0|diguanylate cyclase|EC 2.7.7.65|Nitratiruptor sp. YY08-13|TrEMBL
MDCKQVSLKKELHDGMKEQVADIAKKTLAFMTKSGIDLTPINYDEWFFVMCKAISEQHVL
SQKNLMVLHQKYFKDLPKLEDLEEVKEVSYNLKNIAQGSEKALDAFASNIGMHDQYIQES
IDAINGQDLQKMESLIGKMLNLEKENRKLKKILEENRQKLEFIESKFNEQKKEAQYDALT
GLLNRRSFDKDMEQLDKIKMGYSLLILDIDNFKKINDTYGHLIGDEVLKEVGEILRNYVR
KNTKAYRYGGEEFVVLLPEGNKIAAQKVGERLREVIEHKNLKLPNSGQMLQYTASFGGAE
KQPNETYKEVLNRADKALYEAKRTGKNRVVIK
>A0A2X4TXL4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MTGILALSALLLAWHGKYGQKRINLPFISILFGGLWATHIALKYPALGHYDFSFLLISLL
SVLFIGSIAFSANIVAFTLYALPSVALCLWLNGNEQGLRILYLMALPMVGIAIQHIIQKR
YDNFAQQLMFKLLAERETLNSLSMLDPLTGLYNRRGLQSRLDTLQALDSHEHYVLLLDID
HFKAYNDHYGHMMGDQALIRVSAAIRDAVRSRDVVCRFGGEEFLVLLTATEPQQARATAE
RIRQKVYDLKIPHMFNESVATNVTVSIGIAPLADRNIGDAIEKSG
>A0A5P9IL50|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MGRIKDHWRHWVSSGQQRASLAASLLDGFPGVAMLVNGDGVILYVNPGFERYSGHPAHTM
LGRRITCLDVDPLHGDIGRALAHSVTRRAAWRGVLTCRRADGRVTHQQGVFQPLETRSGD
PLRLLVTLQDITALHRGAVDDHHRLSALQDTVDRLPGVVFQLRQSVRGDLAFCYLSAGLQ
ALAGLSSRDAMESAETLLARIYDEDRQRLNTSLAQSAVSLAPWSLEFRLAQGDEVRWLEA
RATPRRQRDGDTLWDGVLLDITARKEEEQRTQTLVRTDMLTGVLNRRAFFDYGEAVRALA
ARHGRSVPLAMLDIDHFKRLNDTHGHAAGDLALQAFATTCRDCLRPYDLFARIGGEEFAV
MLVDTSPEEALGVLDRLRSAVEALELDVQGACLRVTVSLGLAVIPPQGSLDFALSQADAA
LYRAKREGRNRLIVAPGYPTAPERLR
>A0A5P9INH4|diguanylate cyclase|EC 2.7.7.65|Halomonas sp. THAF5a|TrEMBL
MRRLLLTLLAPLMLAVALIASDGAEAMALDRGWEYRWGDSPLLADGTPAWIAESQGDDAW
QPIAFPANPPERDGRRNAWFRVTLPEGEWRDPVLYIDSVDLITQAWLDGERIYQHGHFDA
HGAGGFAGWPWHMIVLPEDFAGKTLYFRVFSDYTAIGLWGEVKLMERPAMLADILTGSAG
DLAVSAFLMLLALLAFVFALIQAHRLSFVGIGLFALAASLMLLAETPASQLLLDMPLLWD
YLAAAGYYTLPLAMGLMLEHWFADQRPWLLRRIWQLHLGYVVGALGLALAGVVDLSITFP
IFDALLVVSLIVMFTTIAVRLGALNGEQRLIVLSYGLFALILLVDMAVAHSLLGWWPVPV
NGGALGFALAIVGISLWHYRETQQELERLNRSLERQVAERTQTLQEMVMKLQAFSYQDAL
TGVHNRRYFDELVEHEAAMARRNGTPLTITMIDIDHFKQFNDREGHEAGDTVLIGLGRLL
THHFRDSDEVCRLGGEEFVVVMPGATAAMVEARLAELMEILARTRFRYRDRVLDTPSISC
GIASYPEHAGEPLTLIGLADKALYSAKHRGRSRIVTYA
>A0A379SQR8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MAASSPHGAMTPQAADDKLIGLISHWLFPLPVSQPIWHNGRTIGEVRLVVRDSLISHFIW
LSLAVLTGCILLASGIALLLTRYLHNGVVDALQNITEVVHDVRTNRNFSRRVPDQRSEEF
HLFAQYFNSLLDEMEEWQPTAQG
>A0A8F7YPF4|diguanylate cyclase|EC 2.7.7.65|Bacillus amyloliquefaciens|TrEMBL
MKKQTIDEVTAFHQKMLSFFLTKSESVSLSDSLLWLASALESCFTSLSLTLSPAESTRFT
IKTEDEPHYAPLKESDGRFMIRNQTSGRSFYLCSEGGLPIPESLPEIVTQFINQSVRQSG
LFDKTKHQRKIHRMTEMFHSLLDQNEVLEKLQASLSTAFRSFRFSLFITQDQDTDRQLPA
KELHMDGKDADPSALKVYLSGRLLRKGRSSAYLPIKGQQGTYGVLKTEGLQDAVLSCSTL
SEMLLLAGAAGKAFENAQLYEQSKKSIANLELINETSRQLNQRLRLTDTMRELAAIMTQS
FHAEEVAFFHIDHFETQNLLPGHTAFFKTERANPYISIVKEKLFEGEKGVFIGSGKTVFG
ENGFGSLMAVPMIENDTVFGFAILLKKDLYAFTFEMYKLFQALIHHATLAVTNSMLRDRL
EHLVQTDQLTELYSRTYLDEKIQYSMKIHKRGVFILVDIDNFKTINDTYGHQTGDSILIQ
VASVMKNHIREHDVAARWGGEELAVYLPNINVSSGERIAKRLVRAIRENTEPRVTISCGV
SCWSKTGPMPLKMLVQQADEALYIAKRNGKNRLIIHQNSTTT
>A0A7L6DQ83|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00903|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVFVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHIATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTITHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A330LPA3|diguanylate cyclase|EC 2.7.7.65|Moritella yayanosii|TrEMBL
MLKELKTSIIIQLIFAVSIALSVITIYAIDSDKHQQQRLAIQNLSRSYVNLIETNINQAL
SATFPLAALIQNQHLDEASFSRFATEMLPFYPGVAALQLAPNGIIQYIAPLAGNEKAIGH
NLLTSPNRNKEAFAARDSGKLTLAGPFNLVQGGYGAVGRLPIYLDRPSGEQFFWGFVIVL
MHFPQVLDAVKLPALVEAGVAYQLSRINPDTGQLQVLSNSPQPLLANPVANSINIANVTW
MLKMSPINGWVHYISLLVMSLLSMTFTILTTFSAILIMRIKDNQKSLKNIVAERTKQLGD
NLTRLNLALTSTGQVWFELNIQSGEVLFGGQNEQLTDVNPSDIQTILEQWLEKIHPDDFE
LASNRYKASLVTGIPFELEYRRKTKDGNWLWVHTGCEFTAWDAHHKPIWCTGVHTDITQR
KQIELRDNARNAVLEKLLKGDPLKIILEHIVNFIEQEQTGALCSVLLINAQGTHLNSGFS
SSGIPDYYNEAINGIEIGDGVGSCGTAAFTKKRVIVENIQTHPYWTQVKELTAKAQLASC
WSEPIIGANNQLLGTFAIYHRQPSTPTDDDFKLLEFAVQLSVIAIERYLSDKKLEMMAHY
DMLTKLPNRSLLADRFKSGIAHSHRTNTMLGVCFLDLDNFKPVNDSYGHDVGDQLLIAVA
QRLKANIRDEDTASRQGGDEFVLLLGDIESLEHCDEILQRINYFLAQPYIIAGHTFNISV
SIGVTLYPDDDADLDTLLRHADYSMYQAKLTGKNRFHLFNPERDQQTIQKHQQLDEIKQA
LSNNEFALYYQPKINMKTGKVFGAEALIRWFHPEKGLIPPLDFLPIIEGTELENQIGDWV
INQALKQIVEWQKQGIFMEVSVNIASYHLLSAEFLTLLESALASHPSLNAKYLQLEILES
SALGDLNTIRNILDTCRDVFGVNIALDDFGTGYSSLTHLKNLPANTIKIDQNFVKNMLDD
PDDYAIIKGVLALADSFNREVIAEGVETTEHGLMLLAMGCYAAQGYGIARPMPAADIPNW
LHNYIPNQQWLDSGLNKDNIEELK
>A0A6C8Y8P2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTV
SLPLDNDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAAQEREKK
>A0A6S6WL36|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MLSKSTSINSPLDPRYRRVQFLKALLWIIIVVAPLLAVVNYIREQHSLMVALELGLLAIA
AGLFLWLEKQPKAVLVISWLVTLLISSVVAVYIVVSQGQSYSLYWLAVIPPVAYALLGGR
WGLLLSAAFLLGVFSFISVTEATWSDAPFTIDSLLNIIIATTALIILLRYIEQTRSDAFH
FLHQHSERLKSIAVTDPLTGLFNRVQLDHDLNHSLVKARQSDSGFSIMLIDIDHFKRVND
TYGHQVGDIVLVELAQILRTRIRSTDVAGRWGGEEFLVLVPNSTSQQCVKHAEIMREAIA
HFSFHDGIRITASFGVASFRNGDDSESLIARVDKALYQAKAEGRNRTVSA
>A0A7D9N2N9|diguanylate cyclase|EC 2.7.7.65|Pseudidiomarina piscicola|TrEMBL
MPTSSVNHQLTNVSWGLGFGALAALTNYFLAVEVYGSVTILLGQLFVFLALFSRGLSAAL
VAAVMSAAAVYLYTQNLFFFVTLIAEVVTVYALFQRRMPILLADLLYWLALGIPATYLYL
PTITDLPNDFLLLILAKLVFNGLLYTALAILVFQLVPRSWRVVPMQSVSDSLTGRIFYLS
FLSIIVASLSVSFLYTTRSARQVEAQIVSDLSSKANSLREVTDDFLNDYVVAVRNLRDNL
QAVASYDEQVEIMDRTQHNYPSFVSMLRANAEGKILHGAPNHTMSELLKQNTTVPDIDDR
DYFQQPKETQQGFVSSAFRGRGFGTQPIIAISQPLLTENGFQGIVEGSLDLPELTRLVRK
TDIDPQFQAVVVTDDQDQIIFSSEKFSLVSLANFTPRNVINLYSQELPLTRIDNEDLLYT
QRINSYGWNIYVFSTPSRLTDLFSYNLIILVIFLAIITTLLALVTRRFALEITHPLDSLA
EQLKQDTNADLSFDKSEMSREVRTIADSLVAARKLMVSFNRQLQNQVAEKTSDLEHLNSK
LEKLAHEDGLTELLNRRTFDDLAEQRYHEAMATRQPVALILMDIDHFKRINDTMGHPVGD
ECIRSVGWLLKEYFERQGCLVGRYGGEEFAVFMSDSRDLLKLAEQFQNALATQCQANGET
IPLSMSMGIVEVRQNFSGGSFRRLVAQADKLLYQSKDSGRNRISIETL
>A0A8F8CMX0|diguanylate cyclase|EC 2.7.7.65|Lelliottia amnigena|TrEMBL
MFPKIMNDENFYNKGVTREEWQQDLSQDDHHRSGIRFARRVRLPRMLGLAAMFFPIAGAM
VAHAPPGGWWLLLVGWSFIWPHLAWQLAYRSADPRSSEILNLKADAMVAGVWMGLMGVDV
LPTVALVMMIGMNLMGAGGVKLFSAGAVITAVATLITLQLTGTTPALTLTPLELWLSLPV
LVLYPLIFAWVSHQTAIRLAEHKRRLELMSTRDGMTGVFNRRHWEILLRNEYDTCLRSHR
DAAILIIDIDHFKNINDTWGHDVGDEAIIAVTRQLQLALRAGDLIGRFGGDEFAVVMSGT
PAESAIAAMSRVHERLAALTLPCAPQVRLRISVGVAPLTPEFGHYREWLKAADVALYKAK
NAGRNRTEVAA
>A0A4U6LHL1|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
METYLQTVKDEWVQLINETDPYVHQLAAQLAHVHAPVLIAEFYRVVLADPNAAEFLTTEQ
VERQLQEALRRWLIDVLSCQVEQVEEQMRAQQRAADVHARIGISVDLVEMGFRVLKKLLL
PLINTSPHTSEIKLNIYHYAINSIDLAMEVMSRAYVFSENNAAKEDENYRIFSLMENAEE
EKERQTNALLTWEMTLLYKVMFDSSIGNSSPLGQSDFGLWFSHKGRHYFSGIAEAGHISR
LIQDFDDIFKDIRISDDALASKPRRVKFLQQTRNILSQIVTLLRELFDEVSRHEVGMDVL
TRLLNRRFLPTIFKREIIHASRSGIPLSTLLIDVDKFKQINDTWGHNTGDEILRKVAGAF
YDNVRTCDYVFRYGGDEFLIILTEITVADTLRIAERIRKGVERIKVNSPTGEPILLSLSI
GAAMFNGHPDYERLIQAADEALYGAKRRGRNCVELWQVP
>A0A2N7R744|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MSSKLPSPPAGAPAGATNTAAGTPMNPADIAREAFRRLATRRIAPTPSAYRDIYNEIAGI
TEPADTPAAPAAVLAASAPTESGAENVLTQFAAKMSESAGELGDFGRRFQRALKARDWDS
YARTLAQLAEKQVKKGGGIELPPLPDGEQTRTLRELLSRTLGFAVATLLTGTPALVEEAE
SLGAAIKQAHTEEALNEAALRLKQLCYQIELKSGDTAEQQELLLRLFKLLLDNVSQLLDD
DSWLRGQVDAVQNLIAGPLDQRALEDATRSLKEVIYKQGQLKHSLSDVKLTVKNMMMTFI
DRLGQVAASTGDFHEKIGGYSEKISQAENISELNSVLDEVLRETRMVQNEALRARDKMVL
ARQEVQDAEQRIHTLEAKLQHMSELVREDQLTGSLNRRGLDDVFERETARSDRRGTPLCI
AMLDLDDFKRLNDTYGHLAGDAALKHLVKIVKETLRSMDVIARFGGEEFLILLPETTVDA
AASTMTRLQRELTRHFFLHDNEKVLITFSAGVALRHPNEDQAELVKRADRAMYQAKQTGK
NRVVVAE
>Q18C34|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile (strain 630)|TrEMBL
MNKHNFEVILNQLQINIYVTNIHTNEIIFMNKKMKEEYNILDPEGKVCWQVLYPEKNSTC
SFCKVLELLKNDKKGVLIKWYEKCNKLNRVFENYDSLITWQDGTVVHMHQSIDIANSTSL
NKPIKINEFHEISNNKEEKGVFNFSRDNFDYNSTLLYDALIRGTDEYIYICNMKTGVFRY
SPSQVELFDLPGEIVKNPLVYWKKIVHPEDWNRFYKSNTEIGKNQMDYHTVEFRAKNRSG
EYIWLRCRGQLMRDEFGEPSIFAGIMTQLGKQNKIDSLTQLLNYHEFMSVFEDKISNPMI
EKLCIVLLDIDDFKNVNEMYDRDFGDNIIKTLAQSIQSILPDNAELYKLDGDEMGILVDN
VEENEILTLYNQIQNMIIHLQLWRKYGLNITISAGCVIYPKHGDTVKELYKCASYSLQYA
KEHGKNRLVFFSQEILKNKMYSLEMMRDLKASINDDFRGFSLRFQPQVDTESHKIIGVEV
LLRWTNDKCKAISPLEFIPILEENDMINIVGAWVLRMALRTFRKWIDYYPFFKVSVNVSA
VQILEDTFIEDIVKIIDDENFPYQNLVLELTESHTVQNMSILQFKFKALQDLGIYIAMDD
FGTGYSSLEVLKFSPIDIVKIDRVFVKDILKSKFDATFIHFIVAICHDVGIKVCLEGVET
QEEYDLVKQIKPDYIQGYLFGKPQTATEIFDLLKLDN
>A0A6N1KY35|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lwoffii|TrEMBL
MNNECMARLAEQWEQICQNYSSDDLLHAFHFIQDHSLILVEEFYKNMLIEKESAEFFSDD
LIQQRLRDTLNAWLLESFGVGINKRYADAVQKQAMVGHVHARVGIPSWLIMRGVREIERK
MFELLDENLHHSMLTTCSYIVQIMGFATEVMCRSYEAKTAMNQEIKHSYRVFSAMQDVAV
QKDKQRSSLLDWENELMFKVFSEHEKLNHPMLSKSEFGLWFIHKASYAFTGSDQVDLIIE
RIYQVDELNQDIMDCTDKNNMLGLIQRIRDLNREIQLLVDQLFQVAEYIESGNDSLTQLL
NRRYLNTIISREITFSRKNHTPLSLLAIDADYFKSINDKFGHAAGDLALKFLAEALQKYS
QGSDYAFRVGGEEFLLLLVDTDEKRALNIAESIRKYIENGMINSAQGQQFKFTVSIGCVL
YDGHPDYQRFLNAADSALYMAKNNGRNRVYMAHQSLNPVAQPLSV
>A0A259UI38|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MLRIGTTGKYIKYLVVAAVLLPLIFIAEVAYVESQHTQESSQVQIEKLINRRAEAETAWL
SIQAAYVRGIAKLSALTVDEPEIVNNEFRSLLTTEFRTLGYAGNDGKIKVDTSGSSGRDI
SSRNYFAEAIAGREFTGQVSGTDWQLDEEVTVVAVPVTASGAVIGVIYGVIPQETITAVI
AKLVPAGGGEQQEVGRWLAWLGGVYFLGVIPLLMLVYLLHHHKLAGGEPAAAVTPKPDAS
NKRTIVKAPTDRPRPPLVGDPETVTIRKKTADATAVETPETIAVRKIAEIIAADTAEAIP
AAKEKSVEATAFEMAAVKKIAEINAAEMVEATPAAMIDRVRAVAAYKGTGIESATKKERK
PMPAAVLQAVPNEGQEPVQELIPNLPVIDDLTGLYTQSAFEKKIAAQQGQPDSAIVVLSI
DGMKVINDFLGNPAGDTLINVAADILKTVAGPACTAARLDGDRFAALLTDVSPDVFADIK
KDIKYYIDLHNLRQPGLPLSITTGVAAANQGESLTSVWERADRDMENRKAINRVEARKFI
MLSIKRQRQKP
>A0A2X1GR77|diguanylate cyclase|EC 2.7.7.65|Burkholderia cepacia|TrEMBL
MMRPLLHLPPSRMPRPTLQSVLRRAHLRLAFVAVAMAAVSLIVVAVIALRAYAGNNLNLL
ARSLGYTVEAALVFGDRVAANEAIGMIASEEDVAQVVVTDSNGQPFATWQLPAGNGIARL
ERIVADVALPGPVAVPVVHDGIVVGKVVVRGRGHQFFGFLLGGIGGILGCLAVSVFGAYV
SSKRLLRNIVAPLRALAGVAHAVRRERAFARRVEPAAIAELNELGDDFNALLDEFEDWQN
TLRDENASLEHKATHDALTGLPNRVQFESRLARALGDANATGQRVAILYLDCDRFKEIND
CLGHDAGDAVLIGVASRLRTQVRETDLVARLGGDEFAVMLAAVPEAGSVCRIADEILSGM
APSIELSDGRMVATMMSAGVALYPDHASDASGLLRAADAAMYRAKRARPGSWQLAEGVAG
PV
>A0A259UWT1|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MMLIPQGIMFGLAKGTTLVNDKWFSQIEAVSLVSALLLALATPSLLNEWLIGKPLEKMRY
FCSKVKQGDYRERLALPNESRDRDDEDSITILMRDMNWMARQIELREQELKQAVETVRES
RQHIEKQNQSLAETNAELMVIQGRLNERTTELENAFQKMQVMALTDPLTTIANRRCFFDT
LEQQFAALVCNCRPISLVMIDVDRFKTINDTFGHEAGDRVLRELAGIIQKYSRENDLVAR
IGGEEFTVLLPGADSREAVVVARRIKTAVSSRIFELGDEQRISITVSIGICTLSQTPCFA
RNNLYNYADQALYHSKNNGRNSISVFDSTIRSVVKVS
>A0A1T5I0K3|diguanylate cyclase|EC 2.7.7.65|Photobacterium piscicola|TrEMBL
MTGLNKWLRLIILFLVCFTIASYSWFLLGGAKKEYIVTPKNSTYRIIDDSSQNGASITKL
NINNHNVLLECNLVNKAKWPFCEIAVALTDSIDAGFDLSSYDSVGLDIDYASPLEGERIR
IYLRNFDPMYSNINDPLSLKFNAIEYTPGVNEGLKIFPLNSFQVLSWWIAENNIPVDKSS
RQFDNISIIEIATGSYVKESYYAIKLNRLVFYGTWICESSLVKLLLLLWVATATIVILVD
RFVLSQKIKTSEERSQRLRDANRVLYNKSLKFEHLACTDSLTRIRNRHTVIEWLEGIVLQ
TQLNKIPFSMIFIDLDHFKEVNDRYGHSFGDEVLIKFAATVEGLTRRSDVFVRWGGEEFV
IFCPETNMSVAVEIAEQIRETIMTKAWGFDQEFSLTCSLGVAELVDESCEDLIKRADFAL
LKAKKMGRNRIEISWEHQQLK
>A0A259UM63|diguanylate cyclase|EC 2.7.7.65|Sporomusa silvacetica DSM 10669|TrEMBL
MTYTGRIIGSSFIFALSFGLRVYAYYNFNLSFSYPPILGIVCCIVAWWMGKQYDRAKFYS
EKDSLTGLYNRRYVDKVISSLLIQMNRKNAKLSICILDCDNFKYINDKYGHDKGDFVLQE
FSRVLVATNKKSNIVARWGGDEFLIIAPLC
>A0A5K1IZT5|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MNESYRLGEQSVITYLQRLANGFSTAELDVAALPTELRAIGEQLQKTHAILQQERQLLEC
NAYIDPLTNLGNRGGLDRHVEQLWRTGDPFTCAYIDIDHLKHCNDKFGHAEGNRYILSIC
RALTETMEHDELLFRIGGDEFVLVSPTTGEAELEQRLERVRADLIEATSDDKAPMISSFS
FGCSRVDPLAGDTRRQMTLDADRKMYRYKLMHRVQQPKDNDALQHPIAEQFPCNDRVFQA
ISMSSETRYPFILNLDTGESQWSVNAVRDFDLPSQHPFNSVDMWLARVHPEDRDNVRSEL
DMVVNGTWHFHYMQYRVMDATGAYALCDCTGYRLDGTDTEPNMYVGIIINRSLADTTDSV
TGLGDIHALINAIGEMRRVPRKAGFIAIKVDDIAEVNARFGFDAGDRVLAESAACLMDCS
RGKGRLFRSTGPTFVALFDELGPEAIDELASEIERFLGSPVLIDSLEYQPPIRVATLHLD
GVDRQPVSILNELKARLKEAPQVPGTKLD
>A0A5M7LUM2|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. VH_25|TrEMBL
MTIEILSPQNNMPNRWLSALVLGCVVFVLTMFCLELIVVSGKISPLWFPTTLMTVVVFRC
PSRQLPLLLTACVLGTAGANAIIIGPALANIKFALLNLIQAGVGGMLLRALLDRRAPLNS
LHDWARMVVSVGIVTPLLGGLLALWTLQVSGHASFPFFYTWVISEIIGMLVLGPMLLLLP
WPLRRAQFSDLRLAESLLTLLLTLGASYLALRFLPWPFTFIVVILFWCAVRLPKLQAFVL
FFLNASFISMLLAFDLVNVVNNNSALGPVSRWLPFLLVLIPSHIMSLVMDASRREKLHIT
DSETRFRHAMEYSAIGMALVAPEGNWLQVNRSLCQTLGYPAEELKRLTFQQITHPDDLSL
DLQHVSRLLKGEIDTYTFEKRYFRKDGEIVWARLTVSLVRDSSHAPLYFIAQIIDISELK
QSEQVNRRLMERITLANEAGGIGVWEWNLLTGEMLWDKRMYALFGLAPHESPSYDLWIHL
LHTADREYAAMTVQQAIELRSAFHMEYRVVNAEGQRWVRTQANRQLSKEGRIERMLGICQ
DITPLRNLNEALFQEKERMAITLDSIGEAVISTDKEMRVAFMNPVAEKMSGLSQEQAAGQ
PLSELLHITQGRNGPEVENLLLCQLPAEKITPGLAEDLVLHTPDGGHIDIHYSITPLRSE
AGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQH
VLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHHLRSSDFLARLGGDEFALLMPDCEV
AQARDVVQRIVAAVNDYRFQWLGRLYHVGASAGVTQISADNCQSGDVLSQADIACYNAKR
SGRGRLVIYEQHRLPLPGNHQGMNAAMVDALQIELPAWAVAPPKTPQAAFIWLLEVQLLT
ADGLLVDETLLRNNLPDDSLRRRLDNAIVDAFFRHDVQKLNNKGIPVILPLNAQVLSDAA
FVQQLCQRFVAEGLCDSRCGLAFPAASVLSKGDQIYAALMQLRQCGCRIVLQHFGRNLDA
FNLLSNEVVDYLVLAPELVANVHNNLMDEMLLTIIQGLATQRNISVLAGPISVPAVLSTL
ATLDVDGVWGSAVAERQPLRSLAEDHIFAIR
>B1LFC6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain SMS-3-5 / SECEC)|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3S5DNJ1|diguanylate cyclase|EC 2.7.7.65|Streptococcus lutetiensis|TrEMBL
MILGKVSDFLIKHQRLLTYSSIFAALMLLTHLVYDAWIDHDNPTILVTLVVILVLCTVAS
YLNRRQHILSHFILESAKLINVYAVDLDYRFIAVNKNDIRLMEEVFHFTPKIGDFPMNYL
DSEEAARLKVSVDRAKKGETFTFIDTIKTGDKTLYWQNMYSPIYNNRQKVIGVFCCVLDV
TEQRVHELEIQKMAYEDVLTRVHNRRYIELAFEECLMRKEERITVIISDLDEFKEANDTF
GHATGDKILIEFGDILTKIMPESAVIARLGGDEFAVLLPGVSENQAEFLIKLVQAEMTLK
DVGVTASLGVYTDSYQSHKNFVDFCAIADKKMYENKSQKGERR
>A0A5K1IIP8|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCMIVLIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYISFDMIWTLSDGV
DGTLGIAVNWISNAVSFSLFAIVCLIWFIYSETVQGSRLLTSRYRVLLVTLPTALVVVLA
FASYWTHALFYIDARGVYRRGVAYMIQPIVSYCYVIYTSLHAFVHSLRVESLRKKAIYRT
LAFFAIPALVGGTLQVVYSVPGLCVGIMISMLSLYIIYQEQLISTDPLTGLNNRNRFETY
MLSTFSNVDQAEDVYLLMMDADSFKQINDRYGHVEGDHALQVISAALKEACSASGGFIAR
YGDDEFVVLQKATTEQDIMHLCATINDELARAEVPYLLRMSIGYARVGDGVDTWQDLLRA
ADAELYRVKREKKQAGVQIR
>A0A5K1JDP7|diguanylate cyclase|EC 2.7.7.65|Collinsella aerofaciens|TrEMBL
MVKALKIEIFLLCMIILIGLAVRSRRSLFSSTQQLLFSMLGYTSAAYIFFDMIWTLSDGV
STPVGITANWISNAVSFSLFAIACLIWFFYSETMQGSRLLTTPYRAVLLTLPTALVVVLA
FTSYWTHAMFYIDVQGVYRRGFAYMIQPIVSYCYVIYTSLHAFIQARKVESLQKKAIYRT
LAFFAVPALVGGTFQVLFSVPGLCVGITLSILLLYIICQEQLISTDPLTGLNNRNRFETY
MLSLFSGTDQAEGVYLLMMDADGFKQINDHYGHVEGDHALQVVATALKDVCSPAGGFIAR
YGGDEFVVLQKAAAEQDIIDLCSAIDDELARAEVPYALRMSIGYARVGDSVDTWQDLLRA
ADAELYRVKAEKKKAGIQIR
>W5SRL2|diguanylate cyclase|EC 2.7.7.65|Borrelia parkeri SLO|TrEMBL
MQNFDNLAKDIKNFSYIIDKDFLVWPQNSLLQPVNTELIEKWDLKGALKIQRTFFNETLI
KETKKLINVEYDEKSIANYHILISNLEEIYEKCKKNKKIYYQDVLPVVKKVMEFYKKNQQ
TFIKYMKIPKLLSDYHIVHSINTAILTVALGNEMNLNNHKMVELCTIAILHKIGFLFIPL
QISEKKEKLSNEEFEVIKKYPVLGHKILSTTNFSQSICSAILNHKENLDGSGYPNKLKSE
NINIESNIIGAASSYSAILLDRTYKGASNSGASLIELIQDADKKFDKRVLKLIIKVLSQC
PLDFIVELNDNSIAKITKINEDNINVPYIKYIIKDDKIVSPSENQNYVKSIPKTETGIKK
ILRQDEIEFISKKYGLKEI
>A0A1G3HKZ7|diguanylate cyclase|EC 2.7.7.65|Rhodocyclales bacterium RIFCSPLOWO2_02_FULL_63_24|TrEMBL
MESSNPDLPARDAPSVAESEWIAIVGNTDARIRELVSATVSENRQQLAERFYSTMLGDPL
ACQFLDHQQVAERLNKSMQRWLQDLFQVAPATSVAASVAHQRFIGEVHARIQLPINLVAR
GARYLKRWISEHLAQEPRLEREALLAASVYVGDMIDIAIELMSTAFVRGYERTARADEAY
RLFSLGQNISIERERQRAALLEWSYHVLYAKHQRSDENMRSLCHSEFGLWLHHKAQVMFE
GSPEVAQINDAAERIDSLILPRLTASQSPADLSELTGDLQRELASIKFLLSTLFDRYVEI
ENGRDVLTRLLNRRFMPAAINREIAMAKRSDTGFALLLLDLDHFKRINDSYGHDAGDLVL
QQAATLVLNNVRAGDFIFRYGGEEILVMLVEIDHASAQRIAEHIRQRFEENLFLISEGRT
VQLTVSIGIAVFDGHPDYQYVINTADAALYEAKNSGRNCCVVGPVLQAMAAEA
>B7NBU8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A1C6J1C7|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MYKRKNTNNVKVKMNEKVIIAIVFICFILTLTFSVISFYKSKQNQVGIIEKSLEDNGNQC
KESIEEYFEYSFKILNYLANNENIYNMNWDEQYSFLKGQETLLNFEHFIIMDMLGNGYYV
NRNEVKDQSHEDFFHDVIDNERFVTEPFMEVHQNRSITTLSVSIYKGKKKVGALCGVIDL
NKIYNIFKNKVVGKSGYSFLINNNGDYVAHKDMQFVHDSKNIFEDFEGKSNNIDFLREGI
NKGETSLGKVKLNGETYYANFNPLDSVKWNAVFLIPKDEVLSGFNKFVIFQLLALTSGFL
LIIFGVRIIYKNIENHRLAYTDGLTNTNNRAAVDIKFKELDNKYKSNITIISFDLNNFKY
VNDNFGHHIGDELLIKFAGILQETLGSIGFVGRMGGDEFIAILNNIDIEVIKSKIDDMKE
KIEDYNYNKICKLEISYGYFNRGNGDKRPLIEIYKEADKKMYVFKKQIKSI
>A0A1C6F4N5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDRENLEKAYEQALAELAKAKLEVEMLTNTVNGGTARLAVDDGMRIIAASEGYYRMTGYS
EEESFDSPFFRRGVNLVLPQDLPVITAALEKLSRDEPIQISYRIRKKNGTVAWNFAHCSR
INQSGPERTIDVFFFDITDTKQTEIELKNLLDNIPAGVLRASVGDGIHVLFANQEFYRQT
GYAQTEFAGKDIDNQYLRVVHPEDRDHLLERARAFTESQYRCMGIEYRIITKDGQLRWMW
ATGSRLSDLNEPASVLQGIIKDITDERQQRLDVALNEERYRIISEQTKETVFDWDLVQDR
IQFSPVYQKMFGFMPPADLPVRSLTDYDIIYEEDKPQVTRMIDSILNGASYAEAEYRAKC
ADGSYLWCRNRVTTIFGDNHRPVRAIGLLSDINDYKQTATVLQNQAMRDSLTGLLNRMAF
QHSVERILQEYPSGSHAFLLFDVDQFKSINDTMGHALGDEVLKNIASILADELRSSDLFA
RMGGDEFAVFMVNIASAEATLKIAHRLRARIGELAGLTGLKNQTTISLGMSAYPADASTF
EELYKRADRALYEVKHKGGNGCLRYF
>A0A1C6DUR8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDEYKHKKEELMNLLVQHSNADMDDEFQLANELLTLGEAHKDTHAIAFAHTFLADYHLMI
REHEACLKHLHIALNLGEEYHYTDLLLRNYTIAGLYYNSHFDEVNAIQNLLNAYNLAENE
KDLHQKMVVLNNIATMFFQKEDYQEALYYIKMAYQTFLDKKATIMTHADLLVILNLIQLE
IFNEHLDKAIKRYQEYAAKLVSFKASPLSTHVIRLCELYLANASKRVDSVKRIADYFSES
NLHKHKNRTYYFTFYCDIFAILLQIKDQERAEKYLQYMGEMCLEDDVEQQLQLHRNWIRY
AESFHLENVLINSYKQYYMLQKLVEDMTNKTKSESMKEKIKMNQIMKERDRFRNEKNQLE
AQIKIDGLTRLFNRSYFNSLVCAMHKNPHVSTIGIVVADVDYFKEFNDYYGHHMGDKLLQ
NVARCMDENGDSRFFAARFGGDEFITLCVNITKEDICEYLDHIYAELDQIGMEHKMNKAA
EKATISCGFTIFQNDDLFRYEDALTMADAALYKAKAAGKNQYKQY
>A0A6N2VXI8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MDIDMSATRQQMLETAERLNQQMTDGIPFTWETLEQALTSVTEQDDKGIHGWICYFAAFY
QLTTGNQEGCLHYLDESVRCLLGTDLEHHVARVYNMIGIVAHMQNNLSLAMEQYDKALDY
TEKYDDKMVHSIVLSNMSDAYYLIGAYERAVQCHAECIREFEQADDNSTYSRINFRKMLA
EYGCCLLHLHMDDEAEKVLCKLEETGQSEEVIRETRLGVNVFLAHLAERNGDRKKAEEHV
RTAVMALEDMTQVSSEYDSIQNLLQYVEKIGKPEQIEEVLNCLEPKAAIEQNKSLLLQLL
SLRMRYCSSRMTPEEFKQSADTFFHLKDSWELTENSQVMYMMELRKRLQAAEEEQKEQER
KRNRLLYQADHDELTGLYNKRSLNRYLEDVFEDCLLNEKELGILFLDIDHFKQLNDRYGH
GRGDEGICAVADTLKKCFPEDYVARYGGDEFLVVMTGRDREYAEEHARQLCMGIRECEIP
NEDSSVEPWLTISVGGVCAIPKEPNRVWDFLSAADKTLYDQKNEQKGKVRFYVGEGQYL
>A0A1C6D1F8|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MAVKKRKISKFVAVTMAIFVVLYAVVFSTSLYVQKTAEQQCYDTLRKSTENLGKEIKNNI
YSNQEQLEIIADVIASRGNADSEQTKHILKSYMTRGQISHLEVLLPDNRVITSDGNYADV
SGILSYAEEVEKGEYVSPNSTVDISHGDKKVLKCAVPILKSGKTIGILYGIIEVDSLPTY
YVAESYAENASIYLIDGDSGDFIMDTWHLSLGNIADWSNHKVKNDLKTSEIDKDIKSGKN
GYLIGYSERAKENMYSYYTPVGINNWSVMLSIPESTVMKIAWKIKQAMYVMAVITVIIIV
AYFLWLLSLRKKDINKVEYMLEVEKSLFDAHKHTENVDNTLGKVADYMKAETAFFTKVKN
GIIDEVYCWSNKENFDINAAENRPVKVVIPGFNGDGTSMKFGKKLYNLRDYGLPYDYYID
SYIVTSVYDVKKRFVGVLGVVNMDKVWKNADYIENVAGTFSLAVNNISSYKSLREMGIID
SLTGLLNRNCFEQTIENLDKNEYRNVACVYIDANGLHNINNRFGHEAGDNMLKAVAQALQ
SKFGSDKTYRIGGDEFVAFTFGDSEKQIEENIESIKNDIEKQGYSISYGVSFSEVSTNAE
RFIKQAERNMLDNKYSYYHKKSVENNKDDDWTISKANISEHDMDTFLSAVASKFTGGYIV
NFDDDTVRVIYVPKFFKSMLKITNGKFKEALRMYLNEKVDSKYHRNYEPFFDYEWIERQI
QEGNVPEIEFERTNGELAKMQIIKAPDYSENHRETVWIFETIKEVE
>A0A1C5T859|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MNKRKYSKILLVVMSIMICVLIGIQFYLTLYMRRQQELFPEILTWFCLFLEIGLLAVLLA
SSNVNQAVGNLAFTDVTGIKNKLAYQEHINRINERPDTFSIGMVMFDLNNLKKVNDELGH
EMGDHYIEAFSAILSDVQNDRISAYRVGGDEFAMILEQTNAVEIYHVLSGLEKAVDEYNK
KHCIQISYASGYEISTREHYYLMEELARCADEHMYAHKQKSKKNRLDRKKLG
>A0A1V2ZY54|diguanylate cyclase|EC 2.7.7.65|Thioalkalivibrio halophilus|TrEMBL
MPDGGPAVQRQLVDEWQWRLERCPGPVRGRVRELAEQHRASLAERFYAEMLADPDACVFL
DHEDVNSRLNASLQEWIRGIFSVESGSGVEEQAARQAHVGGIHARISIPIHLVMRGARCV
KEQFLTLLELDSAMGHEMRLQAARHVSDSIDMAMELMSHAYSRSHERNARAEEAYRLFAV
SENLASEKDRQRACLLDWENGLMFDLAMGASGDQLPRLSASEFGLWFRHKGVDAFGGAAE
TERVLEAVARIDEALLPSLVCVEARQRQDYLRDVREQVRSIDYHLGQLFERSNELESGRD
VLTRTLNRKFLPVVLGRHIASVQQTHAPFAVLALDIDYFKRVNDEHGHETGDRILQQFAT
LLVSNSRAGDYLFRLGGEEFLMMLVDVVPRDAERIAEKLRTAVRAEPFQGAHGQQLGLTV
SIGLASHDGHPDYQRLVRRADDALYAAKNSGRDQVAVAD
>A0A2X2JUC2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTFLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSIPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPTTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSGWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2X2HQK0|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSAILKGDIPEAETIL
ASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQISLGVYSLERPANP
QPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINRLILHPLRNIAREL
NAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNENAMRFPVSDLPNK
ALLMEMLEQVVARKQTTALMIITCETLRDTAGVLQEAQREILLLTLVEKLKSVLSPRMIL
AQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHCSIGVAMFYGDLTA
EQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNALENHQFAIWLQPQV
EMTSGKLVSAEVLLRIQQPDGSWDLPDGLIDRIECCGLMVTVGHWVLEESCRLLAAWQER
GIILPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRRIDDPHAAVAILRP
LRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPEDSSMIAAIIMLAQS
LNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLEEK
>A0A402ZXD9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A3P6KES2|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAISFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAVYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSIQV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A3R0K401|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFSYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIAEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A0S4HMQ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MLIPGKPVKNGVRADPLRSPQQERQLLRDLAHKAEQELMGVQMASMDELTLLPNRHGFTV
LAQQGLDACQQLDKPTTLLHFKLDELKHINYLYGRAEGDRALKTFADVLRIAFRESDVVG
RLGSDKFVALLLGSSIVDIAAIRARLEEILAERNATVHRRSDLHFSLGQIECEQQLHQCA
EELLAVVDEAMRAGKSLSIQG
>A0A3N2RUH5|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MNKDSTSTTRPTFKKTLRRISMISVITTMTFIWLLLCFASVLTLKQYAQKNLELTGATMS
HTLEATLVFNDPQAANETLATLGKQGQFAMADVYDRNNKQFAHWEWRPEGNTDTLGLLVS
QWLFPVPVTQPIMHNGNLVGEICLTARDSLISHFIWMSFAVLTGCILFASAIALTITRSL
HHGMVDEMQNITDVVHDVRTNRNFSRRVKEGRIEEFHRFGEDFNSLLDEMEEWQRQLQDK
NAQLMRSAMHDPLTGLANRAAFRNNIATLMNDPVAKTHSALLFLDADNFKHINDTWGHNA
GDSVLTEIASRMITFGGQRYHAYRLGGDEFAMVLSDVHSVQDVQRICTALAQQFDRSFDL
HNGQRTSMSLSIGYALAWESNSLELFLENADRNMYQVKNQRSKTTS
>A0A378GKS8|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MEMYLKKMKSEWLSLLEQTEPHIRQLTAEIAVANARMLCAEFYKVVLADPHAEEFLSNEQ
VEKQLKSALERWIIDILSCKEEDIDRLLAAQHTVAEVHARIGIPVELVEMGFRVLKKILY
PVIIFSSQVSADKLQIYHFSINSIDLAMEVMSRAFSFSESSMSKDDENYRIFSLLENAEE
EKERQIATLLTWELDILYKVVLDVDLGNGMPLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LMQDFDGVIHALSAEGKSLGNKAERNKFLIQLRSTVSQILTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHANRVGTPLSVLVIDVDKFKQINDTWGHNTGDEILRRVSQVF
YDNVRSSDYVFRYGGDEFVIVLTEATQIDTLRTAERIRSRVEKTKVKASDGNDISLSLSI
GAAMFNGHPDYERLIQLADEALYIAKKRGRNRVEMWKAGQ
>A0A2H5X6Z1|diguanylate cyclase|EC 2.7.7.65|bacterium HR16|TrEMBL
MGAEHPKKARATMKKLKDLIHSPPIWVNPQHPVKVAVALMQSLHVDVLPVRDGDQVVGMV
TARQLLAVAEEVPVSQVMTADALLLDAEMPVREAAAKMAEKGADVAFVINDTLAGMVRAT
DLILEVSRSYDPLTRLPWQDALREWSIEKLRTGHEISILFFDIDRFGQFNKQYDHVTGDR
VLELVARTIERELDPDLTILCRYGGDEFAVATVYMSGEAQQLAARIARRVEEIQVPKVRE
VISVSYGVFGGRRTREREMVHYAATVDDLIVRASRMCLQMKQRKGTLAMLQLPLPGVEPE
ERVEPRVQVTGISFITQGKEAEASVELAISGLRVLKQVRGDVKQPPEELMVQAARDALTA
LVPGIGTVQVHHVSKVTVDLHEKNEKMDGVMVVVELLTASGNQLLSGFAPVRENVQRAAV
NALLHALNRPLAKWLSQSQLSSSR
>A0A1V5I7U9|diguanylate cyclase|EC 2.7.7.65|Actinobacteria bacterium ADurb.BinA094|TrEMBL
MMRVLLREGTVRYESVRRARDGELVPVEIASSLTEVEGEPVVLSISRDIRERQREVRRLE
ELTLHDELTGLFNRRGLDVMLPQQAKRAKRSGRPVVVMYGDIDEFKRLNDTHGHERGDAV
LVAVARALRAAFRETDLVARLGGDEFCVVAEDISAAHLAQRVDDAMDAAGREVGITVRMS
HGEVVSGWPGLEEPAELLGRADARMYQAKQARRRS
>A0A3S4RID1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRTDKPPLKQRALQKLLLRRFGMAAGTYLLGLVLLWLALLSGFYRAAPTTAAASTTLVVA
CQLAFLWLFASGRNLRYADPSLTEPQVLVAIAWLTYFLYHVDSLRGTFMVFYVLALLFGV
FQLPPRVFARCAALAFIAFSGIYLVEALQQRLELPGRAALQVLVMFIVMVWLSLFASYIQ
AMRQRMRQRRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFMRMASRALEDLLPNR
QHGLALIDLDHFKRINDRHGHAAGDRVLQTFAAVARSCLRDGDVLARYGGEEFVLLLPHA
DAEQLESCCERLRLAFQQAEPVGVTVDTLSLSVGMTLLYADDDLDEALQRADQALYRAKR
GGRNRCDATWEVTSA
>A0A379IGW7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPLQAVRPKILGFISEQASAWLVALVVLLVGVALTAVLALATADVYQQQVRQRFQLLVNE
RYSRLEERFEDQEQRLGSLRRFFVNSHAVSREEFDGFAQPLLSRTRAYAWAPRVFRDQRQ
AFERQVSLQRGTAFSIRELNESGTLVPAGERDEYVPVLYSQTQSLLGSPLGFDLLAQPLR
RSTIERAYRSGTIAVSQPMSLVGVEPAYAMGVLLVAPVTRPRTAQMSYNEPYGYIMAVIS
MRQLVADGLPKPSRDNLVMQIVDTSDTQQRVLYESDNAVGDSSLEAMRRLTLGDHVYALK
LRPSQVFAQANHSSVTSILTMGCLLSVLLSALLYVLVSQRQRAVRLVQQRTGQLHQREYE
LRGAHGQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGYPASQALGHMTLESLHLAP
ELEARAMQLSHTLGKRIMPGQAMLVEGADSLHQAREWTLVRQDGSQLTVNMLATALLDDH
GLWIGHLAICLDVTEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPNDNWRFIYASDG
IRDIYEIDPGLLQQDAKQVFERIHPQDAERIRASIRLSALQLSHWREEYRVQLPGRGLRW
IRGEATPEELPGGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLKAEM
SRVRRTSGALAVIMLDIDHFKRINDQHGHAAGDGVLQELCRRIRQRLRRSDVFCRLGGEE
FMVLCPNTDGVQAYSLAVELWEVLRSTPMEGVGTVTASFGVAGWRVDEGVDGLLLRADSA
VYAAKQAGRDRVEVQRLPA
>A0A0D0RED4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MFCVLKPHRWKLSLLLVAANLGLILHLACGELKSVSEWVWLDIVGEGGSALLALVWLGLV
LKSRPAGRVTNYLALGLSCIFFSWWIDSLDEFIRLPDSITWDHWLESGPMPVGMVLLTIG
IYHWHREQLAISAQMEKRERLFREHRLFDKLTPLAGADYLKRQLAGSLQDSRDQQQPLSL
LALDLDNFAAINQAYGHAEGDAVLQALSHLLLLNLRRQDLLCRLAGDRFVVLLPNTGERQ
ARELALELQQAVLGLAHKTRQQGERLQLAATTAVVMALEEPPQDLLKRLNLALARAKQPL
AKSA
>A0A1T3AD02|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRADKARPTLGSVIGRGHLILALVAVTLASVSLTLLGVLALRVYADHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVAQAEVFDANGKLLAQWVRPETGMLSQVELALAHAL
LEQPISQPIVRQGQRVGSIHVVGHGGSLLRFLLSGLAGIVICTALSAWVALYLARRLLLG
ITKPLQSLAAVAHAARSERDFDRRVPPAQIAELDNLGSDFNALLGEMEAWQSHLQSENET
LAHQASHDSLTGLPNRAFFEGRLIRALRGAAKINERVAVLFLDSDRFKDINDNFGHAAGD
AVLVAVAERVRAQLREDDLVARLGGDEFAILLAPLHKVEDAQRIADKIIASMDVPIPLPG
NTQVLTSLSIGIAVYPDHGATPGTLLNAADAAMYQAKRLSQGGQQTAESEPTAANVNHRS
>A0A5E6MVV0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSAAEGNGLPLASRLYKSRTLGLTLGFVCVVFGMYPLDPAWWVWAWMLINAFVWPHVAFQ
LSLRSANALRSERRNLLFDSFCGGFWVGAMHLNPLPSVTTLSMMTMNNVAIGGPRFMLAG
WVAQALGIGTSLWVFAPAFIAVTTQVQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLELEFQRCRRGSAGAAIALIDIDHFKVINDTYGHVTGDI
VLRQLGKVLRQNLRATDLAGRYGGDEFCVILPDMDLNRATEVMDALRNRFNALAYAQDPT
LRVSLSIGLAPYQPSHADSTSWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A564UQE0|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKKKKNISTHYVSAIIIFICAVVISLGVFLLYVQKSIDTNSQKTMTSNVAKQSDHALSIL
NIHYGFLNSIADKMGDSSDILSDENIELLVSLAANTDFERTALIEADGTAYYDNGAIKNV
AQRKYFLEAMKGQATLSDPLDSSIDQETRVILCVPVRCNDRIIGALGGFYNVTALSQMLF
NDIFDDAGYSLIVTKEGEIIAYDGEPSYHKITYGDNFFDFYKDRTLLSKNSLVNVKKDFS
AGNDGLIKIRTDSNKKSDQYIAYTRLGMNDWMICYVIPVSDAQSSYSFIKSYEGIFMSVF
FILVLLLVFYIIHNNHIRNEELRRDAQTDGLTGVLNKRTTEARINEILEQRPHEKGTFII
LDVDKFKEVNDHYGHAVGDIVLSTLGQTLRNYFRENDIIGRIGGDEFVIYMCKTESKERA
VTRIQALADTIKNLSFAEMNGQHVTISIGISFAPEHGTCYMDLYKNADTALYETKQNGRD
GYFLFQKQDSII
>A0A109LLA0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPANLKLRPRMRSLLSPAVTQAEGVGIIAWVGMLLIPAALKLNFYMLGVTVGLLIVCRVH
ATTTNFLLWRVLGVTYMVLLSVGFAYLIHMNKELRIYGLPLAVTLVVGSAILFISVQDYL
ADALLIWLILWPPMQADIYVGTEVYLLLFCAASVSIGFILSYSYLKNLRSVLLVESEFRA
LAETDYLTSILNRRAFMQSFEKLLGGEQGGYFIMLDIDSFKEKNDLYGHDVGDKILRAMA
LCLKNAKGSHSFGRIGGEEFGVLLQGDDVEVACDYALDLLQAIRSSVSAPHHYTCSAGMA
RFSPGDELSAVLKMADKNLYGAKRNGKDCVHLDGALLKAVLS
>A0A240AVK8|diguanylate cyclase|EC 2.7.7.65|Serratia ficaria|TrEMBL
MNARSYQELLNSKQRLSVFLFLLMNAASSVFTLLVPFNNKPSLTLPLLSIPIFCLAALLF
TLQSPRQYIKKLNQFAIVVGLLWAAHIYVKSQYCAPNNQSFLLISLFSIFFISAIALTDN
FIAFCLHAVPSAMVILLLDGMHNTMRILFTIVLPIIAFSIHHLMLKRSEIFTRTLVANLY
HERDRFNNLSMLDPLTGLYNRRGLENKITMLPEPQTGRHFVLLLDIDRFKAYNDNYGHAM
GDRALVQVAVAIRDAVRSRDIVARYGGEEFLVLLTNVDEEYAARLAERVRQRVLALEIPH
QFNQLETTTVTLSAGISALEKLDVESAIGAADAALYLAKNSGRNTIQLAQNAPPAAG
>A0A0M7AK71|diguanylate cyclase|EC 2.7.7.65|Roseibium alexandrii|TrEMBL
MTFLCEQVVSEIDRHDLNCDPRIFHVLHLFLTEPDSTVAREVQRLIASEEGLTAKALLFV
YENFVQPNVSSEKQFESMKRSHGHLDAIRSSAENSAELCKDAKRKSTKDDVIKALSDNMA
EILSRTDKLEQELAASQSEIFTDSLTGIYNRRYLEAEFAARHSRPSPKYFLALLDIDHFK
NVNDTYGHIIGDQVLKLVATAIKSLIRSQDVLCRYGGEEFAILFDSADETECADVVERVR
LGVTKHKLVNRKQGQTIGSVTLSAGLALVEPDDDFDTALERVDRLLYKAKQAGRDRLVIQ
T
>A0A379JBA5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPVDLQALYPKLIHLMLDTVFVVDRDNQIAFVSDACETLLGYRADELTGNLITDYMHPED
LATTRASIIRVMNGQPHVDFRNRYLRKDGSVVHILWAAFWSEDVGARIGVARDITALTQA
EEELRFLAHHDPLTALTNRSLFNDRLDSALRNARRQNSTLALLFLDINDFKGINDVHGHA
AGDRVLCAIARRLEGCVRDTDTVARMGGDEFTVLLTDLHSEEAVAEKVQQILAIMAEPLG
PEFGPVTMPSCSIGVARYPADGDNADTLLSHADGDMYRLKKIHRAAAKRAIC
>A0A173Y1W6|diguanylate cyclase|EC 2.7.7.65|Blautia obeum|TrEMBL
MKKKKIIILSIMIIVVALLLEASILKYVNDRNAHRTSKVLLDRVITVLDKNDESRSELIE
SLKDDYIVRAKAVSYMIDADSAVEYDVDELQKIAKLMAVDEIHLFDDQGTIYSGSAPRYF
GYNFDSGAQMEYFKPMLKNKSLTMCQDVTPNTAEGKKMMYAITWNEDGTKMIQVGIEPKR
LLNEIKQNNISNVVARMPVYKGIEIIVADADTQVIEGATDSSKLGKKLEDVGISANPDSD
DGATVTQIRMDGKHCRCMMRQNDNYIVFVTVEDSFYQQGGMIAIFIVGAYLVLASCCITY
MFSKVMKERLEKEKLIYTSNTDELTRCLNRHAYENDMKKLNLSEEWVYISADLNGLKRAN
DSYGHMAGDELICAAADCMRDSFHEYGKVYRIGGDEFAVIITENPNQVEELIHSFDSNVA
NWHGKFVDSMTVSYGWVFSTERNWGSAYEISKAADARMYQSKERYYKESGADRR
>A0A5E7VHI8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAKTGGKGLSLARRLYTSRILGLALGLVCVSAAMYPLDPAPWVWGFMWFNGLVWPHLAYQ
WARRARTPYHAEHRNLLIDAFLGGFWIAAMQFNPLPSATTISMMAMNNVAIGGLRFLLAG
TAVQILGVGVGLLIFAPAFIPATSAVQLYACLPLLCLYPLALGWICFRQAHTLGCQKREL
LALSRTDSLTGLLNHGTWKDQLEIEFLRCKRQQKGGAIALIDIDHFKTINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNRAIAVMDALRDRFATLGYEQSPA
LKVSLSIGLASFNPAHADATLWLNDADHALYEAKTTGRNRVICCGNGKPYRELLDSV
>A0A3S4RH68|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MARTTLESIQHAIEVNSSLALPIALENLSRLTHLALLTVPFNLIHILVFSLKDFRPDLGH
QLWRQEIMYAHGAMALLFGGIGLLALWLRRQPPKLWRMRLLILLGGAGIIGFGVAIACID
QRITSNITPLLLACFACAMFILIRPAYAVPFYGLAMLAFEVAMDHAQADPQLRLSNQANG
LTAFGLGLLLSLILWHGHVRNLRQQRKLELQRQELEEKNRQLEYLAGHDPLTGLFNRREF
DQLVLMELARIARQPQPLSLLMVDLDHFKYINDRYGHPFGDEVIRHAANLLRGNTRSSDS
VARLGGEEFLLLLPDTAEQQARSLAEKLRERLEGTPLATQDGVLCLTASFGVASLDGGGQ
ASYEQLYSAADQALYRAKSSGRNRVEVIRLASLAESLR
>A0A5P9JRR9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF7b|TrEMBL
MHAVLLALLLCLGTLLPAHADTAVIGARDSGRNLNAHVELLMDPGAELQVTDLQRAEVLA
RFQPAQGKASVGQSPHPWWVKVTLQRTSDAPAHWWLEVGSVTLKDLRLYLPDGEGGWHER
QSGELVGFHEGRDHPYRRMLFRLPELSDQRPLTFYLRSYDPAGNSFPLKVWQLDALQEQA
VGENLFLGLIYGLILAMLLYNLFIFLSLRDTAYFWYVMTTSGALLMILGMTGHGFQYLWP
NGPVPFWLDRISIPALWGFSACRFTQTLLQTRRFVPWAHRLLTFALCLYITAVLLNFSGL
RAFGAWVFVVLALTAIPASLWASFRRWRQGYFPALLYLCGFGVILGSVNLLLLRATGVIQ
PAAWSGYVFPLAVAAESILFSFALASRIQILKQERAAALEHADREKSARLKQVQASAEQL
SLAVEARTAELAQANRDLSEREIELKQAAFHDPLTELPNRRYLIERVEAAMAEAARRGES
IALLLIDLDHFKPINDGHGHDAGDLLLRTLGQRLRGLVRSSDMAARLGGDEFAILLTGPN
VEQDAGQVAERLLHELSLPVRYRGTSLAVTVSVGAAFFPQHADEFARLYKAADERSIAPS
SRAGRAGSSRTGARRPISRYSGAARARSPWSAARSRWCRRPGRARQWASASPTAPPRRQA
APAASRSGPRRACPSTLARPAARVVHGSPPRCRKARYADNHRRSHS
>A0A1C5ZSN7|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MNITKDKFFSSELLQSDMKITNKVKYTILQMCCAFVHLMLIFIFAAFGVYPMVIFNIFST
ICYLSCGILVKKELYIPLYYITFVEISLHSYIATILVGWETGFPMYIIGITPIIFYMHFS
LSENSTLYETLLIGLCSLATFVSCKFISYKTEPLYTIPDEPSFWIYIFNSLCTFAMLVLF
SLIFLREIKSAHTKLENQNAQLDRIAGIDALTGLYNRRSMDKFLAAAMSCPNDFSIIMCD
IDDFKKVNDTYGHKSGDKVLQAISKIIVSSLREDDFVCRWGGEEILILISGTSLNPAAMA
AERIRSQVEKMSVDSDGQAIKCTLTIGVAERSEGKSTDDIIALADERLYKGKRSGKNRVV
ES
>A0A1C5UD39|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MKTIIKYELVINEALRSALNYDTPDEQINEFIRFFGKHIGSDRIYIFEDCDKRHATDNTY
EWCADGIIPEIDELQNVNMDIIDWWYEAFSKGESIIITDVEEIREEHCISYNMLKAQNVK
NVVVCPLYYKDEIKGFFGVDNPPKSDYRGLTTFLDMVGTLLVSFLKLRNSFIKSNNMAKL
RSYSSLSKIYEAMHYINVQTGRYHVVKTTVQFSECLEKDARKMGEYEIRDDFYGHIKHFT
EKVCIESQLEEALEFIDIRTLEERLQGKISITHEFTDKRTGWCRSRFIPVDYDENGSLLH
VLYCIESIEEEKKRENRLLYLAQTDLMTGICNRGSGESRISAYLKERKAGLLCLIDCDKF
KSINDTYGHAVGDKVLIAIAETLQKVCRDKDVIFRLGGDEFAIFMPGMMEQKAAEKFFAR
LFENIRQIDIEEMEGKSIEISMGACFYEGTEEVSFDELYKNADSVMYQSKEKQGCSAMIY
GLYTDKKDS
>A0A737HYL9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 44:z36[z38]:-|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVAPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVAGTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A2C9ES95|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MSQRLTHKAIQSLLFKRFAIAAGTYALILLLFWLAVVTGHSRASSGSALLGTGLVLASQA
LLCWVFVSGRNLQFADPSLTEVQVVLGIAWQTWLMAHLDQARGVFLVFYLLPLLFGLFHL
SRRAYLRSAALIFFCFAAVNLWDGYRLLLGDPQLAALQVCVLLVMLVWMCLYAAYVQASR
SRMRQRRFALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFLRIASRELQAMDQEQVHG
LALIDLDHFKRINDLHGHAAGDQVLQAFAAVATACLRDGDVLARYGGEEFVVLLPECDAE
RLTSCCERLRLAFTEVQLVGLNVRDLSLSAGMTLLRAGDDLDHALQRADQALYRAKRDGR
NRCSAAWENLDA
>A0A2C9EKF0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MLPAQDTRGKGLSLARRLYRSRTLGLALGFFCVAAGMAPLQPAPWVWGFMLFNAFAWPHL
AYQWARLARVPFRAEYRNLLVDSLLGGFWVGAMHFNPLPLATTLGMMAMNNMALGGLRFF
LAGSAAQVLGMGVALWLFGLAFVAQTTPEQVYACLPMLTLYPLALGYICYQQAVTLGRHK
RELLALSRTDSLTGLLNHGAWKDQLEIEFQRCKRQAHGGAIALIDIDHFKAINDTYGHVA
GDVVLRQLSKLLRQNLRVSDQAGRYGGDEFCVILPDVPLAHAAELMEALRGRFGALGYEQ
SPALQVSLSIGLAAFNPLHDDAMGWLNDADQALYAAKTCGRNNVTCHPPEQPSRRLLNSL
>A0A1S1V780|diguanylate cyclase|EC 2.7.7.65|Andreesenia angusta|TrEMBL
MKNLDYKNLIEDMPICYARHKLILDAEGNPTDYEYIEINRAFESTLGIEREDIVGKKITE
VLPKIKNDSFDWIKFYGEVALSGVSKEIDQYSEQLGSWYKVKVVCPREGEFITYFMDVSE
EKSEINQKIDIIMASSDIVFELDESYRVKDVVVKDERSLFISREEMVGQKLEELLLGEEL
KEKLRNALERAKQSQETESLVYESIMNDGKWYASSIKYLGHKDNPKYILSIHDVTEKRLL
EMRLNSEKELLETMLHSIGDAIISVDCEGRVRLMNPVAENLTGWRLDECEGEKLSNVMML
YRIDNEDEELKLEACTKGINKGLKEGLLKSRDGKNYLVDYRISNLHSSSEEGIQGSIIVF
RDITAQKKKHREVLYLSYHDQLTGLYNRRHFEEELRRLNNQSNLPLSIINLDVNGLKLVN
DAFGHKMGDALICSVSDALRRACRSDDVIARIGGDEFTIILPRTSRKSAEHIISRIYAEI
EQEDLESVVVSASAGCGTKDSSEESLAKAIKQAEEAMYRKKIIESKHMRESTLQKIKDKL
FSEYSFAEEHSRNVSRYMRLLGRYLGFTDKKLTELDLLGELHDIGLVVVDAEIPNKKRSL
NRKEWKDIKRHSETGYQILKSVSHVSRISEYVLSHHERIDGNGYPNKLRGSEIPLESRML
AIVDAYDAMTNIRSYRQVFSKEEAVEELKRNAGTQFDEEILKAFLEILEKEW
>A0A8H9P088|diguanylate cyclase|EC 2.7.7.65|Citrobacter farmeri|TrEMBL
MEMYLKRMKDEWVRLVEHTEPRIRQFASEIAIKHAHDLSIEFYRIVLVDPHAEEFLSNEQ
VERQLKKALEKWVVSVLSSSVDDIDQLIKEQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PVIIEGHHEATDKLLIYHFSINSIDLAMEVMSRAFSFSESSAAKEDENYRIFSLLENAEE
EKERQVASLLTWEMDLIYKVLLDSDLGNSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGVFHHTSGTAKALNNKALRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRAGTPLSVLIIDVDKFKEINDTWGHNTGDDILRRVSQAF
YDNVRSSDYVFRYGGDEFVIVLTEANQTDTLRTAERIRSRIEKTKIKSPNGEIIPLSLSI
GAAMFNGHPDYERLIQIADEALYTAKRRGRNCVELWKPAS
>A0A1U7M781|diguanylate cyclase|EC 2.7.7.65|Tissierella creatinophila DSM 6911|TrEMBL
MESSKLLSKEDLISFETKFFNLFETIDDMFIISSLDGNIIYCNMSLLNKMEYSFQELKNM
NILDLHPKEKIEEASIVLREILDGTRDKCLLEAISKSGVKYEVETRIWFGKWNEEDCIYS
ISRDFTKENENLRLISKIFQNNPMPMIITDIEERKFIKVNPVFLEKTGYLEEELVGMRVD
KLNIVVDMKRYEDMRNRLLSGEEIKDEELVIKCKDDSFLTGLFSIEEINNNGKRAFLIVM
VDITEKVALTNRLRNKLQKLTNIIEGTNLGTWEWNIITGEVEFNEQWGKLIGYSLEELKP
ISIKTWRRFSHPDDLKLSDEMVKRHLKNEIDSYDCEIRMKHRDGRWIWVRDRGKVTERDK
SGRPIKMFGTHSDITLAKEQSIELERFFSVNIDLLCILDMKGRFLKANKAWEDILGYPVD
TLIGRRAMELVHKNDHHNTLESIKKLKKDGKLTNFINRYRTIDGEYLYFEWRTNLYNDVI
YAASRDITERMKYEEKILDASNKDCLTGIYNRRYVYNRAEEIIERYKKREDDFSVCIIDI
DYFKGVNDKYGHRIGDLVLKEFTSVIKENLRPYDILGRYGGEEFIVILNDIDEKESVLIL
ERILNVIRNKTFNCNGNDINFTFSAGVANCKEIKKEEIVIDRLIGLADKRMYRAKNAGRN
RIASRIK
>A0A8A0RQT2|diguanylate cyclase|EC 2.7.7.65|Koleobacter methoxysyntrophicus|TrEMBL
MIHILIPLGDVNTTAHLITNYLAEKNGSFVVLVILAQKPEVLIFKKGDVRQTLNDGMLYD
ALSEIRVSQKVSGKLKCLIGRYFNEGSIIIPIYGTRAWIISSSFIGSTEQLQACVAVALK
NAEAYERLKKEAAEDPLTGLYNKKYLYIRLREEMARADRTGEIITVLMLDIDSFKEINDC
HGHVFGDRVLKKVAQTIKRNIRTSDIASRFGGDEFVVVFAGLKNAKEAECCIERIKKEIY
EEMGINASTGIAVYRKGKRKVSPEDLISAADEDMYREKKEIQKNYL
>A0A3A8F1Q2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. WCHAc060007|TrEMBL
MPQNVSIQLSETWKSICEKYSALDHHLTLELITKNLDAFVAAFYKQMLVEPESAEYFSDN
IIQKRLIDTLKAWLLETFNVALNGQYENAVIRQQKVGNVHARVGIPSWLIMRGVREIERT
MFEYIASDSSTNYMNVVSYVVQLLGFSTEIMCRTYEDKTAKNHEVKHSYRLFSAMQDVAV
HKDRQRGSLLDWENDLMFKIFSGQGKFYQQLFSKSEFGLWFIHKASYAFAGSEQVDLITS
RIYKIDALTEECMKLEGREELMLMVQKIRSINREIQHLVDQLFQVTEYIESGNDVLTQLL
NRRYLNTIVGREISYARKHRSSLSLLALDADYFKTVNDRYGHAAGDLALKFIAETLQKFS
KGSDYAFRTGGEEFLLLLVDSDLNRAKTLAESIRMCIEDATLQTSVGEYFNFTVSIGCTQ
YDGHPDYQRFLDATDLALYSAKNRGRNCVYVTEVQKMA
>A0A395LDH2|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MTRQAAANTSRSQTKSTAIILKVAHSMSQLGIAALPRNYELVYEALSGRLPQLSRDLSAL
GATPQQEALDELGFKHHLIAHGALAADRARATAQEELSDLALQLRHSLAQRHAFRSQLDR
FKDRLASDPVAGLTEFADDAARLRDAAGLLMNEEQAFLTALQSSAERFAALEGAFAESRK
PLTRDPVTGLPNRLALSARLKTLLESEGETQPVALIVASVEGLRGIAEQHGAATAEKALG
KLSTLFRKSIKKSDFVARVGGQEFAFLCSDVTEENAQAIAQRIRQSVEALRVALPGRAFT
AETLSLAAGIAMAQPMAPPTDVVQQAELALAALRAGSRSGVLVYSAELGGRRARTYSPHA
A
>A0A1U7MER6|diguanylate cyclase|EC 2.7.7.65|Sporomusa sphaeroides DSM 2875|TrEMBL
MVLVLNCVDGELELIVLNSTNSSGSAIEWLTISRDNSGRKQHEQRIQEMETDYRQIFQGS
PVVSIIIDPDTGNILDANQAAVDYYGYTLEELQVMTIRQINIAPRGEIDECINKVSRNHY
KAIPFRHKLKDGSIREVEIYSGPVKLKGRILVHSLIIDVTARRRAEADLRESNRRLRDFA
EAVSDVSFIIDEDGRYLDVFGDEKMLPMPGTEFLGQTIHQVLSEDSADFILNEVQQAIIS
GIQRKGIYEIQIGGEKQYFLGRTVPLTYIVNGKRTAAVIAADILEQQENTLQMIYELRRR
SDIISSVLDGKVDSNKSFAYTCSSLGLDINLPSFVCKILNYSLDSGDSNSQLAKINCDRK
RKDKMMIALSEIPNCIVWGCQDGIYVLCYATFGKREWERSKEIASLIRTKLLEDDSSMSV
FVGISEVHTGVEGLKKNCRQALSAVLAARSRAVDGGGVVHYREAGLFQFVSEPLSGNAAR
EYIAQHIGNLLEYDQTKQTNYLVTLEELLRGASIRETAEKQHLHPKSVIYRHKSIAKILN
VDLNDYQTRLTLGLALQLYKLNANNL
>A0A8H8X683|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPVPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVVEMQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKVINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAREVEFICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A2T0B2A7|diguanylate cyclase|EC 2.7.7.65|Clostridium liquoris|TrEMBL
MEYNSMTYEELLIELENKEKRINQLTEEVRQLESIANTDFMTGVLSRRCGLNKLKESMEK
SIKNKENLIVCFIDIDKLKIINDSFGHDEGDKLLKIVTDIIEKSVRKKDYIFRMGGDEFI
LVFTDTNMDEVDVICNDIDKRINYINEKRLLKFRISVSKGLARFDFNKNTTLEELVKQAD
REMYKDKLKNYTDGL
>A0A330GRI9|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MNKQYQRVLVTTPHPLIRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSVSLIYPSINVIEAAIGALLLRRLLPWYNPLQN
LNDWIRVAVGSALVPPLVGGILVSLLAPGPEPMRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLDTDL
EQLEQLVNGEINTYTLEKRYYTRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRAHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNFDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNIESARYI
AGRLIHTINDYHFTWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGRV
TVYEPQQERDRHTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTYAAQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVSSAEKNLQRGLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVSNVYGNLMDEMMVTIVQGHAQRLGMKTIAGPCNQPIMMDTLSG
IGIDFIYGDTIAEPQPLDLLLNASYFAIN
>A0A240EKH7|diguanylate cyclase|EC 2.7.7.65|Vibrio thalassae|TrEMBL
MLIVIRLCFLLTIVLFALSSRTAFAHFSPLNLVENKPYKDTAIALSTTRFSNSSDGAHLI
EQLYRTSLIGKDPITAYYYYLAKFKYYRAQKRPSDARNMLKALRKVGTNNDLVWVVAESD
MWLATFDITDGRYDVALQRAHNALVVAKDIDYLHLEARIHNLIAVIHSSQNRQLQAKKSY
TTALELFRTLNDAAYVVKVISNISLIYADLEEWDKALKYNQEGYFWLLKNQKTMLEQEAI
LAINRSIIEGNLGHLQQQAEYLDLAEIKAEQLGEVSLIANVTSNKAYNLLKKGNYQQAKL
AAKECLAIAERHQLKTQVPHCMTHLGQALSFLGQNQEAESLLISATEQFLALKDPLNTAK
AYNQLAEFYAHTQQFEEAYKNARRYQEENEILLFDKRQKALFELEQVHADSENEHKITQL
HTENKLKQSLIENQDSREKMWAAILVAGMFGFLLLFKSKNTLQQQNISLLSTNHSLREQS
MIDPLTRVPNRRFAEHYLSGDRTLPGNGHIAIGLIDIDHFKAINDKLGHAAGDIVLQEIA
QTLNNLLTDSELLARWGGEEFLILVRAATISKLQERLATLRTAVESINLYFDEGSLIVTT
SIGATLLGPTNYQKHWRNKLDIADKNLYRAKSEGRNKVVFS
>A0A517TD16|diguanylate cyclase|EC 2.7.7.65|Calycomorphotria hydatis|TrEMBL
MPPATSLDPSFANWIVWILCAGGLLSSGLCGFVIGYYAAKRDPLKELQKASESILKLQQL
VLSRLVEAKAACDTLATVGSDAMNKSQLTHIENTRNSLWKSLQNLSSACGLAEMPVEPSE
SETAEPRNVEVEWITETIDEEVDLPDREAFNNNLQLLLDACEEAGGEAGLLLCKIDRFDR
LAKRVGEQAASVLLKQAGRVLIRAVREEDLVCRFSDDAFGILFRGVMGSSARQLASAVRD
SVRYHAFRVEADGPEILVTASFGFSPCRPHENSDLVLHRAGDALSRSQKRGRNQLHLHNG
AIAAHAPATASPPVPAGAGT
>A0A144IIH4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MPPRTASDLYSEMKNMSVEERIRFFSLSLAEMHSELQESISQIESMKQALEESEEYHRQL
VETAQDAVITIDHAGNVVNWNQAAERMFGWSAEEAIGNSLGKMIVPEAFREQHARGLMRF
KAGQPSNILNRTIEIAALHRTKGEFPIELSIWPHQQAGKQIFSAFIRDITDRKQREHIAW
LHANFDALTGLPNRRLLVNRLELAIAQAIAHDKEVALLFIDLDRFKPVNDLHGHAVGDEL
LRLVAFRLQSVLREGDTVARLGGDEFVALLPDLTTDDPLPPQTAEKVSAALAQSFLINEQ
VITISGSIGIARFPHDAGDADTLLNSADKAMYTRKRVTPGER
>W6RGE9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas pseudoalcaligenes (strain CECT 5344)|TrEMBL
MLLLLPVLTWAQSLPLPIGQTQTLPGPYMAFWEDPDGRADITDVHALPDSAWQAVERRDA
SFGYSGSTYWLRLDVHNPHSRSLGWVLLIGNPLLDQLDAYGLDGERIYRAGDQRPFDWRW
VEHRQLVLPLHVVSGERQRIWLRMQTDGSANLSASLMTRDAFDHQEQRSLLLQGLFFGAL
MAMLIYSLSIFCITRDRNYLWYSLFVASFSLYQFIQLGFALQWLWPNALAWHQLSFPLSS
ALATWFGIQFTYGVLDLDKAARPYRWVANTLKACAWLVLGMALFGLYAPALIGSFVLVTA
CALAAFVITLLRWRGGYAAARLFALGWFVLIAASLASILTGTGLLPYSLLTLHAQQIGGL
IEMTVFSIALASRIRQVQQAERQAQAKLIDHERRLRSEQTKHLELQTQISESLEQRVQER
TATLQDTLQQLSNANLRPAELNRRDGLTGLFNRQTLSEELARACARAVRSRQSLAVLMLD
LDHFKQVNDRYGHLAGDACLRHAAQRIQQRLRSSDLLARFGGEEFVILLDSTDLTGALDL
AEQLREELALNPCLYQQQSIALSLSIGLHAGVPSEPDCGEHWLELADRALYRAKASGRNR
VVSYEANAFNDA
>A0A1Y0HMY4|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MKRIPRILLKKPILLGSITFVVNLVISMSPVLYLHGKHVAHYKSIPSFNTQLLIEEQDIV
YSALFYSFIFAFIISILITFLAFFLKKSYLEVENLSHFDGLTGLYNRLMFMSVFQKEIQK
VKRNRDYLFLVILDIDDFKPINDTYGHLIGDEAIKITASTLQQLLRASESIARFGGDEFI
ISIVDQDKNAASTIVNRILNEFNNKTIPVSRNHDQQELQINLSIGYTLYRNDDDFKTMLQ
RADQALYISKEAGKNTATFLA
>A0A1Y0HHV2|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MRRIWESKFLPWVFLLLGLLFSCLIAWKCALWIDEKEQIRFQTASNTITNLIYKELNAHI
QLIRSVAAFMCVSPENISREKWKQFAIKNHINEQFLGLRALGYAPLVHPQERLKYEQAVR
HEEGFADYAISQKNVSSNTALFPIMYLEPMSEMNEKAFGFDLASEITRREALHQSFIRAD
ATVSSKINLTQKYITDNQVGFSIFFPLYQTKDIPTSTEERLASAKGVLFIAIDAKKMFEQ
LLKSHYSLVDFEIYDGSAPLEQNLLYNSNPNLIDSRLSGYTSLELYGKIWTLHFKAKEVF
EMSDSRYYPWIQMLFSLIFFSVFAGLIYVLQRTRKKAYAIANEKTKQLSQSEAEIRSIFQ
SMQEGVMVLDDKGVILECNLAAQEMLQLSKSDIVGNFSYNSKWSAIYEDGSVFNKEDYPS
LMAINSSLPQNNVILGIRRKDGSLIWVQTNAQPIFSDNFDKIRSVLITFSDITAYRKSKR
ELEKYLQIIDTHVIISSTDTDGIITEVSEKFCQISGYSKEELIGKSHHLVRHPDMPSTLY
EEMWTSLKKGIPWYGEIKNRSKKGVDYWIEAIIAPRYNEEYQLIGYTAVHHDITDKKRVE
ELSITDRLTGLYNRLKLDELFAYHLSIVKRHQTSFSIILLDIDKFKLVNDTYGHQVGDSL
LQAIATLLKRNIREEDAVGRWGGEEFLILLPETKSDAACLLAEKLRRLVEAENFEYAGNR
TASFGVATYHANDDETSMVARADEALYRAKEKGRNRVDLELYSLTTS
>A0A1Y0N6B8|diguanylate cyclase|EC 2.7.7.65|Curvibacter sp. AEP1-3|TrEMBL
MPNRLRVRRSVSLRRALRMLVVFSVLPTAIVGMLLAYANYRLQRESVEQQTVLVVRAIQS
DLEREMAAIESALKTLATAPELGNGNLPGFYQRATQALGSGSVLNYILTDREGRQVLNTL
LPFGTALPTRGTPAQLGKVFDSQTTVLTDMFTGVTTKAYIIAMGVPVVSGGKVIYSLNIG
LTPDRINKIIARHPIPEGWLVAVLDSSRTIVGRSREPERFVGQKAVPELVNMLAQRDSGF
MESVTKENIPVFTAFSTSPLWGWTVVSGAPKAELHRELLIQLAQVMAGLLAALMLGLWLA
RRAGLKVLSSVGELNDAALALGRGDDITLPTLELQEAQAVGTAMLQAADAMRKVKFFAQH
DALTELPNRLLFDELAQRSMSMALRRDSELALLALDLDGFKAVNDSLGHSMGDEVLKTVA
LRIAQTIRGSDVAARIGGDEFIILLSEVSAETAMQSAERLVEVLSEPYPGVGLPLGVSIG
VAMFARHGTEMKTLMLAADRALYAAKAGGKGRAVLASG
>A0A085G649|diguanylate cyclase|EC 2.7.7.65|Ewingella americana ATCC 33852|TrEMBL
MTDNLLERISTALEAEYTLEGLVRQLLEMLELVTNMESTYLTRIDEDGAQQHILFSRNGS
NMHIPEGLSVPWGDTLCKRALDEGRRYTCDVAGVWGDSEAAKALGITTYVSTPVTLADGS
LYGTLCAASSEHRELSERSEQVLQLFANLIAQQIQSEQLLKKLQLANDALTTASYTDELT
GLPNRRSLFNQLPTLFSQAHANSRYVLIAFADLDDFKEINDVHGHEVGDDFLVAVGQKLK
EGVRADEVIARVGGDEFIVAGAGPAEFSEAQQAALAFKTRLSELLTGEYQLQSCLIDYAG
PSIGAVAINPTDTTPDMALREADAQMYEEKNRRRRWRVA
>A0A826L3N8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A252BM41|diguanylate cyclase|EC 2.7.7.65|Gluconobacter sp. DsW_058|TrEMBL
MTVDALLSNSKQLSPDEVEWQLIIDAIDPAIRSAVADMVENHAAASVEVFYSTLLTHPEA
TPFLSNQIVNDHLHSALLRWLQSLFSSTAPDLAQLVATQRRIGLVHARMRVPMHVVMHGA
RLLKNTLRKLLFEIFLTPADLSTAIDYIENMMDLAIEMMSREFVRDLQKEIETDEAYRLV
TLGQDVTLEREVQRAALLDWGHKILLAICCNAPPPLPSLESSGFGLWLNHKGSLLFPNTM
GIEHIRTSMRRIDRVLIPALSAQVPPDTARIHELQAQIEEIRFLMDDLFKESEALESGRD
PLTSTLNRRFLPTIMAREVAQSLRREVPFSILMIDIDHFKSINDRYGHTGGDAVLRGVAE
KLISSCRTSDFIFRYGGEEFLIALVETDIKRAFQVAEHIRENVTHILTQPTGSSFSVTVS
IGVATFDGHPDYTHLIEDADRALYYAKAEGRNRSVIATDALASLPQLQ
>A0A8J8AZV7|diguanylate cyclase|EC 2.7.7.65|Coralloluteibacterium stylophorae|TrEMBL
SYTALDMASRVAASRGRVRLAWLAGGGFAMGVGVWSMHFVGMLAFRLPIEVGYDPAITAL
SFLLAVAASTYALHLVSAERLARRRLAVGMLVMGAGIAGMHYGGMAAMRMLPGIVYDPLL
FVLSVAIAVGASGAALWIAFRLRTAVHRARLLRGGAAVLMGAAIAGMHYTGMAAAGFPAG
SVCGAATVGIDAGWLAAVVVAMTLAVIAVALSSSSIDARIARRTDQLSRSLAEVNAELVH
RALHDPLTRLPNRVLLEDRIGQAVCKAARGNGRFAVLFVDLDGFKAVNDAWGHQFGDGLL
VEVAARLRAARRSTDTLARLGGDEFVLLIDIAEPADAATVAEDVLRALAAQFEVAGHPLR
IGASIGIAIYPEDGAGAQALMANADAAMYHAKDAGRG
>A0A826LDS9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O6|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5P9CJD8|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MELDIFNPSRHLRRAVLFGLSALLGSLCLIGVIVNGFFDDYPQVASAQAFFCSFSCYVAF
HSYRGNTSLLLSNGYIYSFMSLISFNTYTYSIDNGVLVWSFLYPVLSYLILGKRYGMIAT
MVGFVAQFCLIIDKCILSKDNIIWELPLNFVTAYLSVWLASHVLEVKRKTSETSLGQLAS
RDALTSVYNRHALIHNFERYRQESEKLPLSLLVLDLDYFKQINDKYGHDVGDKVLVQTAA
LIAGLSDEHLVYRIGGEEFCIALHNTTIKNAVSKAEEIRIAIENHTFNTPEQPIFQTASI
GIYQCDLFNDLDSVLRNADKELYKAKKNGRNQVMVCHEHKETIMGALS
>A0A399ETI6|diguanylate cyclase|EC 2.7.7.65|Meiothermus luteus|TrEMBL
MSVYRRLKFSKGLLEPLDSPSQAWEGVLSELLRTLPEGTQAFWWVRDGAGRFSLRAALGL
AGMRPEEVGEVEEATFQEVYPGPVNRWRQGLPAAEVGPHLLSHLLAQPPAPLEEAGEGQN
LLLPLVLEGRVWAVLHLHTPSPLGEAQVKRAARFIRATAPLLQQTHRWETTERQALWLRA
INALLSHPEPENPHPLEASEVASWLGLRLLDALEEAARLSRADGARLVALEEGRVHTLVQ
AGWGAGLPVEAALGPVLAECLGGGQRIGLPRYDLYPGRRPELVEAGLRSLFILPVPYQSQ
ALLLFSNQPGWFPNGQTLDFLTEMANALGVVQREWALRQELAWAAFTDPLTGLGNRRAFE
HDLEKLPHRPSERLAMLVVLDLDGFKGINDTFGHVHADHVLVRLGGVLRSRARAGDRAYR
LGGDEFALIIEAPRDLNPNRIAERYRALVEEVRVSESVYLQVSLGYAVYPSEASETEALW
RLADDRMYQDKALRKHRASVSSSHLAQYETPLVRLARHLGQALQLTPEELEVLQASCYLL
QLTLGEIPPAPGPTFSDGLLRESARLLVFLHHPWEGGPPLGRAGEPIPQAVRVLQVAHWL
TQALKGAEGRPAQSLEEALSALREEQPQRFAPEVVEALLSLRLKEVLT
>A0A1C6HG09|diguanylate cyclase|EC 2.7.7.65|uncultured Flavonifractor sp|TrEMBL
MLAILLAMGLSLGKSARQRIRTPLEGVRQLSEGWYRLEAGRRVEVQIPGTVTLDSGEALT
LYYDGLNPTDAGLVLTTRGAVYRLRVDLGEESLYAYDDSTFRRNEQMRAKLDCDVVLPEE
TGGQPLILTYENAGDGRFALPAVYLGSSSAVFRQHCLGDAFTLLLVFTMAIISVVAIGIA
SYLDKVRMQDRRFADVACFLLLCGAWCTLDSSLMQQMSGQSPLVCYLSFYAFMTLAIPML
HFVRNTGEMCRFRSLDVLIGAFYVNAVGQSLLNFFWGFDFIDMLFVTHLLLAAGICLMGV
LMLREYRRTGNREMQAVLRAFAMLAAGGALALLLYWLLETPWYGTIFECGILVFIICLLS
SLITTMAANLRFKTEVQVYKRLSREDRLTGLENRRAFEEFLARLEQETGSYGNVALIFLD
LDGLKYTNDHFGHSAGDELLIGAARCIEQAFCRQGSCYRIGGDEFAVILPDPAGDERAWN
EQLDQAIRQYNQDSRFWLSIARGSSYLRDEAGDIKRMSDWKYEADQAMYRHKKQQRSRRQ
GSARAAVAGRERDSAGGFLG
>A0A645FWT5|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MHEQAKRDPLTGLGNRMAYDEYLTIWNRKSNITLSVINIDLDGFKNINDVYGHQEGDEVL
KFFARKLEEVFGGIGFAIRWGGDEFILLLNEKRRERLEKYVKMLNDKIDAYNDSNDMPYR
IQFSCGIAIFDDSFDNVYDFIRHSDKLMYQEKQKKMCLKNLVETPAPD
>A0A645FWZ1|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MGFPITYNEENVGVIVLYSNTTEALNGIENQMIYDFTGQVGIAIQNARLFNQIEEMATVD
GLTGAYSRTHFMELCDAAIEEHSSTNKILSLIMLDIDYFKKINDTYGHLAGDKVLKELVS
TIKEELNETSIIGRYGGEEFLILLKETDLETALNIAEKLRTRVESMQVRISKECCVKITS
SIGVVSYNKNFENISQLIEKADEALYISKENGRNQVRAVLARSY
>A0A645FC63|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MSRKALHDAMRDIEADTQTNSYILVIADIDHFKLVNDNFGHQHGDVCLIAFSEILQSECE
PNTVFRYGGDEFCLLFCNAEMEQVVAACWRMLRKVEALRFEAKPESTLTASFGIAAFHLP
MNAAQLFVQADQALYQAKEARNTVCVYEP
>A0A1V5T7T2|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin269|TrEMBL
MLHIKVLQAVDIYALSLIILAVIGFKSWNAPKEKMTQTRLFSALIVLTALTSILDAVTVV
LDGVPGKPVRLVLQLAVAIGYSLQMSVCVMWSRYVRAIVYPDPKRSGWKIYLENAIIIVV
SVVAISSFWNGLLFSVDQNNIYHRGPLFPAAALLTFSFLFVGYADVMRNRTYVDRHTLFA
LLCFALPPAIGGFVQGLFYGVCLLWPSMSLSLLIVYIGIQNDQLMIDELTGINNRRSFDR
TLSRRISTARNGNRFGVMLIDIDNFRSVNDRFGHGEADDMLRTFARILDYHFKDTGFVAR
YGGDEFAVIVNLDRYDELDAVRNSVHSRLEEWNQKNKRKWHLSASIGCAPYIPSDGLTAD
ELLVQVDKLLCFTRIIPGERRFRAGRRL
>A0A645CI32|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MIVAIHKKSATDYLTKLGNKRSFSHTVEALFRDAQHSNRAFALLMIDVNRFKQINDTFGH
PAGDAVLKHIAGALAAAMESPRGCFRYGGDEFAILLANASPFAVELSRAAIHEEIEALTI
DELHGYRVSVSIGMAMWEKGKTLQDLIDEADQDLYEQKKLRS
>A0A645EGA2|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MVDIDFFKMFNDTYGHAEGDHVLNMVAKQIDSLIKEQTEFFCRWGGEEFIYVSFGSSAEE
AATLAETIRRAVSDLKILNHASLLESTVTVSIGICTLHTTAPTDIEHAINTADKAMYRAK
SCGRNCVCSLPVSPRFSQDTNP
>A0A5P9GNJ0|diguanylate cyclase|EC 2.7.7.65|Erythrobacter sp. THAF29|TrEMBL
MQTQILGLITPLVAIVIAITFAIMWRLGGMRRHVLGYAISYAAFGTGFLITHLLPASSPF
LFHATQFFYSIGAIVLLASVCERVGQRLHIKSQIAVYLVSATVLALVVSVSDEADPRLLI
VNIGYGVMFVMGVATLLNARRRDWIDLAMITVLTIQAVDFLVRPTLTLMFERSIDVAAYR
DSIYYSLIGLVLAVKSISTAMVLIGATLAEWVTSLRERGDRDDLTGLRNRGAFEHSIRQL
LPRAQVEMVPVSLVVADIDHFKQVNDIWGHQAGDAAITAFAKLLETRVRGCDISGRIGGE
EFCVAIWNCDNAAAEQLAERIRAAFGKLVHEQLGADIRLTASFGVATARKGETYSRLFAR
ADAALFRAKNNGRNRVENSDTEPDPDFAAGPAAPATTAAPIRTAIG
>A0A5Y7A2U8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis str. CFSAN000515|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPLDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A4P9TTA1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLAGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5U9PMX3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Telelkebir|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A125QHZ3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MPAVGGKGLPLALRLYKSRVLGLTLGFVCVAFGMYPLNPSLWVWAWMLINAFAWPHLAFQ
CSLRSANTLRSERRSLLFDSFCGGFWVGAMHFNPLPSVTTLSMMSMNNVAIGGPRFLFAG
WVAQALGLGTALLLFTPGFIAVTTQAQLYACLPILMLYPLALGWICYRQAVTLARHKREL
LALSRTDSLSGLLNHGAWKDHLDLEFQRCRRGPGGAAIALIDIDHFKTINDTYGHVTGDI
VLRQLSKVLRQNLRTNDLAGRYGGDEFCVILPDMPLNRATEVMEALRGRFNALAYAQDPT
LRVSLSIGLAPYQPSHADSISWLNDADQALYEAKSSGRNRVSSVQGSWLRSV
>A0A655WNY0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MLMLFLFEEIEWHRLRSIQDELTGAFNRRHFKEQVQQKLKQSKQKSMVALVDIDHFKQIN
DSYGHDIGDSVITYVVRHLESLALTECLVARYGGEEFAIFARENDFERVSQALDSVRDAI
SVGFHVEQQPLKVSVSIGAVIFESSHEYGEVLRQADKALYQAKQQGRNRIMLQDVSAS
>A0A5M9I9V7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MPAVGGKGLPLATRLYKSRTLGLTLGFVCVVFGMYPLDPAPWVWAWMVINAFVWPVVAFQ
RSLRTTHTLRSERRNLLFDSFCGGFWVAAMHFNPLPGVTTLSMMTMNNVAIGGPRFMLAG
WAAQALGIGTSLLIFTPAFIATTTPVQLYACLPILMVYPLALGWICYRQAVTLARHKREL
LALSRTDSLTGLLNHGAWKDHLEIEFQRCCREQQGAAIALIDIDHFKLINDTYGHVTGDI
VLRQLGKVLRQNLRATDLAGRYGGDEFCVILPGMPLNRATEVMDALRDRFNALAYAQDPS
LRASLSIGLAPYQPGHADSTRWLNEADLALYEAKSSGRNRVSSVQGTWLRSV
>A0A5M9ICV0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas panacis|TrEMBL
MVLEKPFTADSPTADPPRPAAAATLLALVHAQGEVERLSEREQLLSSLLVSVNAVLWAID
WQTRRVLYVSPAYERIFGRSAGLLLADHREWRNSIHPEDLDYAEHSLARVLEQGAVEDRE
YRIITADGQIRWLSDKCYINQQVEPGEPVIVVGMAEDITEKKQLELELHRLATTDVLTQS
SNRRHFFECANQAFDSACAQGAPLAFLLLDIDDFKDVNDTYGHLEGDQVLRRIAESGRGV
LRRGDLFGRIGGEEFAAVLPGCAPEMALQVAERLGREIQALSFSYEGQAFSVTISQGLAS
LTEEDSTLDSLFARADAAMYEAKRLGKNRVIAG
>A0A8B4CYZ8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MIIFFAALVAVISGTSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYS
MYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKV
VKILKSQIPVDKGKIYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAH
SNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A2A4GTM9|diguanylate cyclase|EC 2.7.7.65|Staphylococcus delphini|TrEMBL
MIEAIIYNISVTIAGIYLFHRLQYAESHDFRFSKSYITVLMTIVGLLLAFQPIPIENYMI
QLSFVPLLFLGRYTNSFYTVFAAVIIALVGYFVLSTTLTYAVSLLVIAAIVSTIGPFLKQ
NHVVAIQILNILSIIILAIIAMIMPSFDTVEVLYLIPISMIATLVTAVFYVDLLRFFSLI
ERYENEDTVDYLTGLGNVKEFDRHLNEMARVAEDERQSLALLLIDIDGFKDVNDAYTHHA
GDAVLKQMSHLLQNYVPKKTRIFRNGGEEFSVVLRDCSLDECVKLAESIRKAVEKSNFHL
PDKIVIKLSVSIGVGYMTSESHKSQRKLFKDADDMLHVAKNEGRNQVMFSPIISPK
>A0A377RRJ8|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MTDALPAAPPAALPEVLFSRLLEDALDAVIIIDEHCRIRYINGAMQALSGYASGELLGQT
LNGLLPDAVGAQHDNHVINYIRSSRTSSVLGKIREFAIRHRDTQMIPIEMKAMDLGVVDG
IRYFGAFLLDVRERRELAAKNASLLAQLEQQALHDALTSLPNRRAYEAQAEQAMARAARS
GAALTVGVADLDHFKKINDRYGHAVGDAVLRTVAQALRDTGRITDVAARLGGEEFGLLFP
DASLQQAHRVAERIRAAVAAAITPLPDGGELQVTISIGVASLTAGATLDAAMSDADKALY
AAKHQGRNKVVAAAAVQ
>A0A174RF35|diguanylate cyclase|EC 2.7.7.65|Blautia wexlerae|TrEMBL
MKYNQKKKKENIEIFLFIMVMAVFAAVLGVMSLGEKMQPVNQIRKISSGWYYYDNGKRTE
VTLPDTIQAEKGEELILYNDGITDLDAGKVVTTRGAQYDLKIWLGDRPIYEYQDTTFVRN
TQMKSKLECVGEIPTDMQNEPLKLVYSNPHHGKYVLTSVYIGTGSAVIALHLQNSGIVIG
IALCFLVLSVISLLITVYLKYRQMPDARFRDVALFLMICAVWLITDSSAIQTYSSHPDML
CTISFYMFMLHSVPMLHFAQKIGGLKKERILDAGIAVFYLNAFIQGLLAYFGVFTFADML
FVTHVLLITWVLIVAVLLWKEYRKKPDRSVQIILIAYMILLFSGLLSLSLYWLFEISYYG
AIFEFGILVFLVMIIADTVISLVGKVRYRTEMQAYERLMKEDWMTGMQSREPFENLLAEI
PKTMNEHKDILLVFMDIDYLRRINNDFGRAAGDEVIVAAARCIENVFGAIGKCYRTGGDE
FAVVVFDPEEDRNALSEKLDKEIRRYNRNSRYRMSISRGFSSIRDDRGKLKTTGEWKYEA
DTNMYQNKMKERKTHEL
>A0A2B3SFN0|diguanylate cyclase|EC 2.7.7.65|Bacillus cereus|TrEMBL
MLRDLFVNTTIILSFIFIGGQLLRDKPLKEGFSFGQKCVVGIFTGILGIVLMYFSVRVGT
ILLDLRYLAVILAVIIGGPIASTITIGMILVTRLLFMDYSLASQVAFYTIIAIGIGSIFI
SRMKLSLGGKWVWLHTYILSILIPALYIWLIKEIHIVGLYLISSIITGYITFISANYVLQ
SNELFQKMKQYATIDALTGLGNVRQFDLEMNRHISNKNMKNDSFCLLLIDIDHFKYVNDT
YGHPAGDEVLKQVGCILRETSQFPDLAFRKGGEEFALLIPNKGLAYGILTGEQIRTAVES
HSFQLLDETKIKITVSVGVSEYEESPEQFIQAADDALYYSKRNGRNKVSSVS
>A0A5F1EUJ6|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. E3659|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDSHSYGLCQFGRWIDH
LGPLDNDELPYVRLIDSVHQHMHNCGRELMLAIVENRWQDAHFEEFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLAGWTRDYDTVYRYGGEEFIIIIKAQNDDEACRAGLRICQLVDNHAIAH
PGGHIPITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQSVIARV
>A0A6B0TIB5|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MPHETTPGNWSWLRKLARRFGPGHVVNICFLVVMICSTLLTWREVVVLESAYRASQRNHL
ENVANVLDRQLQFSVDKLLFLRNGMYEALVTPLDFADLHDAVAQFAQLRGKSFWQLELDR
RRTLPLNGVSDAFVNRTTLLTRDNDALANELSAALELGYLLRLAHSSTMLAQRTMYVSRS
GFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQRQNSARGVRWFSSPVPGGEVQQKVTVS
LSLDNKRHWYGVLAMDIPVSSMKRFLEDAVEKDSEGEYQLYDYQLRLLATSTPEKRQVNT
FDDLELALLANDIEHDTHGGIRMGSRYISWERLDHFDGVLLRVHTLREGVQGAFGSISIA
LGLLWALFTMMLLISWVVIRKMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFERARVLIQ
RCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDRVLSHAAGLISGTIRSHDLAGRVGGEEF
CIVLPGTTLVQAAQIAERIRQRVNDKEILIAKGTTLRISASLGVSGAQENGDYDFEQLQS
LADRRLYLAKQAGRNQVCVRDDHPAPSPDTR
>A0A0C7D5R8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MARTTLESIQHAIEVNSSLALPIALENLSRLTHLALLTVPFNLIHILVFSLKDFRPDLGH
QLWRQEIMYAHGAMALLFGGIGLLALWLRRQPPKLWRMRLLILLGGAGIIGFGVAIACID
QRITSNITPLLLACFACAMFILIRPAYAVPFYGLAMLAFEVAMDHAQADPQLRLSNQANG
LTAFGLGLLLSLILWHGHVRNLRQQRKLELQRQELEEKNRQLEYLAGHDPLTGLFNRREF
DQLVLMELARIARQPQPLSLLMVDLDHFKYINDRYGHPFGDEVIRHAANLLRGNTRSSDS
VARLGGEEFLLLLPDTAEQQARSLAEKLRERLEGTPLATQDGVLCLTASFGVASLDGGGQ
ASYEQLYSAADQALYRAKSSGRNRVEVIRLASLAESLR
>A0A2R3J4Q4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MNRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYADPNQQLIARSIS
YTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGRTLASWHRESTGPLHLMEQQLA
HWLLSAPTEQPILHEGQRIGSVEVKGSGGSLLRFLLTGFAGMILCLLLTALGAFYLSRRL
VRGIVGPLDQLARVAHTVRRERDFEKRVPEAAIAELSQLGEDFNALLDELESWQARLRDE
NASLAHLAHHDSLTNLPNRAFFEGRLSRALRDAMQHREQLAVLFIDSDRFKEINDRLGHA
AGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGSDALRIADNIIASMQAPIR
LGDGSTVSTSLTIGIALYPDHADSPAALLHDADMAMYIAKRQARGSRRLADLNDPRILQQ
EKEIDRATPEAPPK
>A0A8F9IIV5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8F9I9N5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A8F9IHI3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O139:H1|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A136WII4|diguanylate cyclase|EC 2.7.7.65|Anaerotignum neopropionicum|TrEMBL
MKIGEKMISFLYLQVNIVGMIIIFIILANQQNIDDGTGRQKAFIYLIYSVFTIQFFDSVM
WLIDGKQFLYAKTINWAVSGCCYFLNCFVAFIWFIYISLLFYDKKIINKKFWAIIGIPLL
VNMVLVILNFKYKIFFYIDENNVYARGPFFFISFLLALPYFLIPFYYCFKIYRTSESILE
KKDCAIIMRTYFLPVIGIVFQMFFYGLSLIWICVVLSLLIIFINFQNRRISTDPLTQLNN
RYQFDMYLQNIRHGITKGQPYSILIIDVDKFKEVNDTYGHVFGDRVLIETALILRRACQG
TGAMIGRYGGDEFYIICKAGVKKEITKGIHQFVEVFNAADSVGVGLSLSIGSSDFLAEES
FSKECIVERADKEMYKNKIK
>A0A2C9CIF1|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MNTPKKAQIGSEYDLFVFAQKESEALKERLFELYLLYSLSKNLNVSLQLNELFHNTINVL
KESLRIEDFCFMLIDDECNELKMWKVDDCSFGEAKGITFKIGEGISGLVAQTGESILIPD
TDKDPRFLFYKGKIPDIGSFISIPLKLNNDKVIGVLNIHKKEKNAFRDTDKMLFVAIAHN
VAIAIDRARNYEHAQKVAMVDELTSLYTRRYFLESSQREYRQAERRGEFFSIIMVDIDHF
KYFNDTYGHLLGDEVLRKLASVLKLNARQSDVIARYGGEEFIILLPGTNKPGAVASAEKL
RSAIEKKLAIEVGGGHKEKVTITAGVACYPEDGNNVEEVTASADRFLYLGKKSGRNKIVS
AATDAKVAIPEKRVASRYMTALKIVSGLHQPQSIEIETDSNWKMCTVKDISKMGFRGEVE
FAAKIGNVYSGKVVLNTDDHKPGQFSIRVAFAKRMCQNRYQIGAEIIDGRDNWKRLFIQT
TH
>A0A1V4IZA5|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MTGIEPSFFENEKALLKDAKELIEDEKRDEKSVFNNFSVIVKQFDKVIRDVEKIIRISDG
QQEYLHRIQSDLKKEIEDRIRAEEKLKYYAAIDTLTGVYNRGMGLALLEAEIKSIRRNKD
VFSMCYIDLDGLKHVNDNYGHPEGDELLVITCKLVKEVIRNNDILCRVGGDEFIILFPNM
QKEDVDEAMRKITLNIVKENEKKLRPYDISFSYGIVQVECDDGKSIDEIIQMADADMYKF
KKKYKKSCFC
>A0A1V4J279|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MQDYEKLYNSLRTEYETYQKFSEQHIQELNEKNVKLEKSIDSLSNIIEVSKYINTFFSSD
NLISMINDMILGILGVTYSTIFLIENGELTIKASNIEEMNINLTSKEFTYINQGEEFLIN
SKEPLKQTGEHKVDIHSIMGSPIKVREKFIGYIIVEHNLYKFMTTELKLFLRSIANQIAI
AIENSLLYKELEQLNQKDSLLGIYNRKYFYERIERKEINNENDKFAIVMIDIDNFKKIND
TYGHQFGDKVLINTANIVKNGIDKNDIFARYGGEEFILYISDFTNEDVVYNKIESIRRTL
EKSQVYFNGESKYVTASFGVSFFPLNGTDLNELINKADDLLYKAKKTGKNRVLSGNIFKI
>A0A2Y4XUT9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRV
LIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGH
QTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A3V8VUJ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Agama|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRAIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A380U3T4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter johnsonii|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHVKAQNFIQQHSSVLVNEFYSNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVAVNEAYYAAVEKQQKVGQVHARVGIPSWLIMRGIREIENK
ILELLAELPLENNHHMLSYMLQIMGFATEIMCRSYEANTERSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIR
LIQQVDTLNFDVLDCQDQAQKVERIQEIRDVNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARKNDAALSLLAIDADYFKRINDKYGHTAGDLALSFIAEVLLDVA
KGSDYAFRVGGEEFLLLLVDSDLTRALQIAETIRMRIQETPIRTAHGQSFSFTVSIGCTV
YNGHPDYQRFLDTADSALYAAKNKGRNCIHVTEKVLSV
>A0A5I3F5C9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Choleraesuis|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPLDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A143HVG7|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQMQTSSAWESFYVMSDIILARVSETLATEQSLEGLVRQLLEMLEIVTDMESTYLTKVDI
EARLQHILYARNSKQMTIPEGLSVPWDETLCKRALDSDTVFSNDVPERWPECEAAKALGI
TTYMSIPVHLADGSLYGTLCATSTARKPLSERGEQVLKLFAGLIAQSIQKESLVTQLREA
NAALIAHSYTDALTGLPNRRAIFEDLTTLFSLARHLKRNTVIAFIDLDDFKLINDRYGHE
AGDQFLIEVGKRLTEEKQQDDIIGRLGGDEFLVASLSTSHSEGDNAQVTLLKTRLSACIA
GEYWLGSVNLIYPGASVGVIEVDPRVTDPDSALRDADVAMYQDKKGKSKTRFLTMD
>A0A5Y2S4C0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAEETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHASAEKLQELADRNMYQAKHRRAERSLN
>A0A2K4DUY2|diguanylate cyclase|EC 2.7.7.65|Staphylococcus devriesei|TrEMBL
MIEAIIYNIAVMVAGIYLFHRLQYSENKIMIFSKGYVTVLMTLVALLLAAYPIPFYDKYL
IHLSFVPLLFLGRYTNMAYTLIAAIIVALVDVFTFGNSILYGVVLIVIGVIVSMVGPFLK
QNDIMSLVILNLISVIILFILSIFSPLYDLYEVAVLVPISFVLTITSAITFVDIWHFFSL
VTRYENEDKYDYLTGLRNVKEFDRHLNHISQVAEENNESLALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPKQFEIFRNGGEEFSVVIRDYSLDQSVKLAENIRNGVEKSSFH
LPNKEVIKLSVSIGVGYLTQDDHKSQRKVFKDADDMVHVAKNEGRNQVMFNPIIKI
>A0A5I2FGZ7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Alachua|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A658AZY8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMPH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRFVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIEEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNYARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGNRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELD
NGLRITMTLSIGFALTWEHATAEKLQELVDRNMYQAKHRRTERSLN
>A0A398R4W6|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFIHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A3V2UQ26|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A154YEG4|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTAIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWGSVSLIYPAVNVIEAVIGALFLRKWLPWYNPLQN
LNDWIRVAIGSALVPPLMGGILVSLLAPGSEPLRNFFVWVLSEAIGALALVPLGLLFKPH
YLLRHRDPRLLLETLTTLAVTLALSWAAITWLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMVVSLMIARNPLALTTQHAGPMLNAPWLPFLMLLLPANVMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVSIEGKWLQANKALCNFLGYSQTELQSLTFQQLTWPEDLNTDL
EQLEQLVNGEINTYSLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDIISWDKRMFELYEIPPHIKPTWQLWHDTML
PEDRVHAEQVLRDSLISRLPFKLEFRIRVKEGVRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPI
LKVLHITFGEKGPLMENIHSGDMSRSDIDQDVVLNCRTGGNYDIHYSITPLSTLDGQNIG
SVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFID
LDRFKAVNDTAGHAAGDALLRELASLMLTMLRSSDVLARLGGDEFGLLLPDCNLESARYI
AGRLIHAINDYHFMWEGRLHRIGASAGITLIDENNHQASEIMSQADIACYASKNSGRGMV
TVYEPQQERDHHTRSMMSLDEQWHMIKDNHLMMIARSVASPRIPESSNFWLLSLRLWTSQ
GEVQEEHAFRSGLAEPELLHALDRRIFSEFFRTYATQIASKGMGVALPLSEAGLASVTLV
DELLDLLDKSPMPGRLLHLVISADVVCNPDKNLHRGLQKLRQAGCRVIFSQVGRDMNVFT
HLTANMADYLMLDAEVVTNVYGNLMDEMMVTIVQGHAQRVGMKTIAGPCNQPIMMDTLSG
IGIDFIFGDTIAEPQPLDLLLNTSYFAIN
>A0A0H5GL26|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSSIKNKSAEQIKNQTNPPKMPTLGRVLGRIHLIVALVSVATAGIFLTVVALFALRVYAE
HNLHLIARSISYTTEAAVVFGDTVVANEALSMIATNEEVAEAKIMDVNGRVIAQWTLPDD
GPMHQMEQSVARWALPEPVVLPIVHSGNEIGRIVIVGHGGSLLRFLLQGLAGLFVCLILS
TLVAIFLSRRMLFGIIGSLNRITEVAHNVSRNRSFGQRVPSAQIAELNELSHDFNGLLEE
LEVWQKHLTQENDSLAHRAAHDSLTGLANRAYFEGRLSRTLSDCKTNEHVAVLFLDGDRF
KEINDNYGHAAGDVVLTTIADRLRALLRESDLVARLGGDEFAILLAPIYNTDDVLIIANN
IIKSMTQPITLPDGSEIITSLSIGVAIYPDHAQTPDELLQRADEAMYQAKKGFRPCEQGT
AYQSDFIYSENKYPENKYPESTHTENLG
>A0A0F7HAG0|diguanylate cyclase|EC 2.7.7.65|Serratia fonticola|TrEMBL
MKLLGQKGSATSRPTLGQVLQRMNLGLALIAVSAAGIFLTLLALFALRAYANHNLHLIAR
SISYTAEAAVVFEDRPAAREALMLIASNEEVSEAKILDMQGIALASWSHPADSPLHGLEQ
MVARWILPEAVVLPIAREGKQIGLVWLTGNGSSLLKFLLRGMVGMIACLMLSTLCALVLS
RRMLRGIVTSLDDITNVAHTVRRDRTFELRVPSAPIAELHELSCDFNGLLDEIEAWQQHL
QQENDALTHQATHDSLTGLPNRAFFEAQLGRALSELEPDEKLAVLFIDGNRFKEVNDNHG
HAAGDTVLITIAERLRSRLRKHDLVARMGGDEFAILLAPLKDTNDVLPIADIIIECMQQP
IVLPNKERVIAALSIGIAFYPEHASTTQELLNEADDAMYRAKHLSHGGWRLAMRK
>A0A3Y2IM59|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A0D5YCC2|diguanylate cyclase|EC 2.7.7.65|Acinetobacter baumannii|TrEMBL
MKIRLITRPINKIKQVILDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKGYILITP
SIWQWANLSLVESQIWLNLLTLFLLAVLIIPCYRYKDQAWAQKIVPLISVQAFMLMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFERKIVYSAFIPATIILAVCTYLSMTGVISYAPLF
NFKTMRHAQTNPFWLGSMLFFIMPILVACFILFEILLTQWRQRETYIQRLSQIDPLTNVL
NRRSLNTHLEALHEQQFDYAVILLDIDHFKKINDIYGHHQGDQVLIEIARCLSENLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRQALQELTIFNNQNIQIHVSASFGISSSAFA
NDPYLVIRQADQALYAVKASGRNQVRTFHQLPQIKSI
>A0A5I4LLV3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kedougou|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8B3UVR4|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MKNITLAEKLIMLSGAALFALMIAVNSFCVNDNPGFRVPMTTYLIVMIALFFLDTIIFIF
IQMLYASDRSRFSLFILSLAFLSGLVYFIETIIVIQIPEHAGFTQAAKTNDTAVFYFFRQ
LSFIVLLALAVRVEKITRRSTLRFRNKISMTLALMMTLVMFPMLAHYLSSYHPAWTLTIA
AYEDEHHYPVWDIRYVNVLILLWSALLCYMISVTRLASGIWNSIIVVCLSAIVYNFFLLL
LDTYNLSLWYISRAVEVLSKLFVICTLMFHVFNLLKIFGDRVDRDPLTQIYNRKYFYEAL
PRVRSLRTEKGTSIMMLDIDNFKSINDNWGHLVGDRVILAVVDIIKDSIRDNDIFARLGG
EEFGLLLPDTDGKQAMAVAERIRQNVQQRTGPGYHYALPVKVTLSIGVCSAIQNNVNGND
IMRDVDEALYEAKHNGKNRIVTRQAE
>A0A315GLD4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:i:-|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A256DMB9|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MEQIEPVNDTLLLTEWQALIRQTSPDVHTLLTSLSDEEIHHLVTVFYDYMLSHAQSALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADDSSSLLSNAICFSSLAMDTALEAMTVSYSPSYQNSLHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWFSHKGKHILGNSNLL
KEMESLIAEIDTRLTTTLSPQHQPTDPERMSLLQDVRQLSAKIHFLLASMFEALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHAHKPFSLAMLDIDYFKQINDNFGHNIGDLTLKNV
AAVIYEHIRSSDYVFRYGGEEFMILLVESDESQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A256DNK5|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MMKNTAEIDAIINELNNSIDAHYKWLVKMFRCAVSSDVTHPDITGDNAHSVCRFGKWIND
QSLNNEDGSSYVSKIYSAHEKMHVIGKELLLAIVENRSHAWHFDSFQDALLAFTSAVMDY
KIYLLNIRSNIDVLTGLPGRRMLDESFDQQLLDAEPLNLYILLLDIDRFKYVNDTYGHLV
GDLVLRVLASNLLSWTRYDEVAYRYGGEEFIIIIRTKTDEQACQAGFRLCRLIGQKKIPY
ADGEIGITVTAGITRVQPGETLDTALGRADRAMYQGKQTGRNRCMFMDENERIALVDTND
GTSYPLSA
>A0A7Z8C0Q0|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MMNDEFYDSHENIREAWHQQLSQDDSYRSGLRFARRIRLARIVGLAALFVPLASVLVSQF
LSGVWWLLLVGWVFVWPHLAWQLAFRSAEPHSSEIVNLKIDAILAGVWMGLTGFNALPTA
ALIMMIGMNMMGSGGCRLFLTGLALLALSALLTVQSTGTPVLLTSEPLALWLTLPVLVVY
PMLFAWLSHRTAIRLAEHKRRLELMSTRDGMTGVFNRRHWETLLRYEFEACRRSHRQATI
LLIDIDHFKTINDTWGHDVGDEAIVAITRQLQLTLRSGDYIGRFGGDEFAVIMSGTPADS
AIAAMSRVHERLVNMPLHGAPTARLCISVGVAPWGAQFTHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A3W0KCI6|diguanylate cyclase|EC 2.7.7.65|Salmonella oranienberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWVALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A2X3FC37|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MKLAGLHPDEQRRLQSLRSSGLLNSGKEERFDRLTRLARSLYNLPVASISLVGEDLLHIK
SCAGLDVDTVPRDISFCAHTILQTDPLIVNDMQQDERFHDNPLVIEAPFIRFYAGYPVQL
PDGATVGSFCLMDHQPRSFSAHEMQILSDLAAIVEDEFKVLDAATSDELTGLFNRRGFLT
LAEYALLTAQRRHEPVSLAFVDLDRFKHINDTWGHEEGDRALIAIADLMKAAFRESDILA
RQGGDEFIILFANTSRHDAATAMETLSHNVARFNQQAAHPWQLAFSWGCVEYDPASHPSL
NALVATADRLMYQAKQKQGRERR
>A0A0D8WEZ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQKNELNPKE
IYQLADNALYEAKETGRNKVVVKEAEILINRKDDE
>A0A1V3VX61|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MHVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAISYVAMLVYDAITTEWGLVSLAINFSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPAIALIVSVIASVVIGGAGSLAFPLPALIWCAVRYTPQVTCLLTF
VTGAVEIVLVANSVIDISVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVA
LRADFDFLTQVYSRSGLYEALKSPSLKQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FARHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKGVELQPFTWQQKTLYL
TVSIGVGSGRASYRTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A826YV54|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAYGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTL
VSHPPSGWWWLVLVGWAFVWPHLAWQLASRAIDPLGREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWELMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHEGLNTLRLPNTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A6H3L1H9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMESRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0D8W5Z1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLFLRKLTEAEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A376JBJ9|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSLSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKSVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYFQVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECATVERL
KMLADERLYKSKKNGRAQISWQ
>A0A366YVU3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIIPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGVASPRITEVRNLWLISLKLWSCE
GEFIDEQTFSRSFSEPALSHALDRRVFHDFFQQAAKAVASKGISIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVLSQMGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVIDTLSGIGVD
LIYGDVIANAQPLDLLVNRSYFAIN
>A0A5J1II10|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Sandiego|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A1L4IXE0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRTERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLVSGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMMAHGVASPRIPEARDLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCAKVQGNLMDEMLITIIQGHAQRLGVKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A827EEI2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A827JZF8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRMVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQLASRAIDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSIAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSLNSAPLEWWLSLPI
IVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWEIMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAENAITAMLRVHDGLNTLRLPSTPQVMLRISVGVAPLSPQMSHYREWLKSADMALYKAK
KAGRNRTEVAA
>A0A3W4DBQ8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSAARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A8H0TL89|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKSGNYTNLCTGSNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANALDKHLQ
YNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPVNGVSDA
LVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQPTLFT
RNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSENYWYG
VLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGNIFDPRELALLAQ
AMEHDTRGCIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWALFTTM
LLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQHPFSV
IQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGASLTQ
AAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLYLAKQ
AGRNRVFASDNA
>A0A828KXT2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVIYRV
>A0A244BVU5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IELINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
IVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEFNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGVSCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSLYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A376RPD7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFLPIASTLVSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGM
WVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAP
LEWWLSLPIIVIYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNE
FDNCRRHNRDATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGD
EFAVIMSGTPAESAITAMLRVHEGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKS
ADLALYKAKKAGRNRTEVAA
>A0A376HIT2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYGLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKSVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A1Y2Y1R0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSENYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLHWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A7H9K2R7|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MYVHPISTFRLFQEGHLLRNSIAIFALTTLFYFIGAELRLVHELSLFWPLNGVMAGVFAR
YVWLNRLHYYAICYVAMLAYDAMTTEWGLVSLVINLSNMMFIVTVALLVVRDKRLGKNKY
EPVSALRLFNYCLIAALLCAIVGAIGSVSIDSLDFWPLLADWFSEQFSTGVLIVPCMLTL
AIPGVLPRFKAEQMMPVIALIVSVIASVAIGGAGSLAFPLPALIWCAVRYTPQATCLLTF
ITGAVEIVLVANSVIDIAVGSPFSIPQMFSARLGIATMAICPIMVSFSVAAINSLMKQVS
LRADFDFLTQVYSRSGLYEALKSPSLQQTQHLTVMLLDIDYFKSINDNYGHECGDKVLSV
FAQHIQKIVGDKGLVARMGGEEFAVAVPSVNPVDGLLMAEKIRKAVELQPFTWQQKTLYL
TVSIGVGSGCASYSTLTDDFNKLMVEADTCLYRSKKDGRNRTSTMRYGEEVV
>A0A265B7I2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A6B3KX30|diguanylate cyclase|EC 2.7.7.65|Bacillus mobilis|TrEMBL
MLRDLFVNTTIILSFIFVGGQILRDRPLKEEFSLWQKCVVGILTGILGILLMYFGVHVGT
ILLDLRYLAVILAVIIGGPIASTIAVSMILVTRLVFMDYSLASQVAFYTIIAIGVGSIFI
SRLNLSLGEKWAWLHTYILSILIPSLYIWLIKDINIVGLYLISSMITGYITFISANYVLQ
SNELFQTMKQYATIDALTGLGNVRQFDLEMNRHIGSKRMKNDSLCLLLIDIDHFKCVNDT
YGHPAGDEVLKQIGCILREISPFPDLAFRKGGEEFALLIPKKGLAYGIRTGEQVRTAVEN
HPFQLLNGTKIKITVSVGISVYEESPEQFIQAADDALYYSKRNGRNQVSSAS
>A0A735VTX1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar 48:i:z|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPASPDEHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKADAILSGMWIALIGVNML
PAATLFMMMSMNLMGAGGLRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQITHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A3E1ZTV4|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MKSPSRPNNEVERLSALRESGLLEIENHPNYDRLTRLAKRLFAVPVAMINLVDEHVVVVK
SAEGADATNLPRNLSFCGHTVLNNMPLVVPDTLDDTRFADNPLATDDNPIRFYAGHPLHL
PGGAAVGSLCIIDHQPRQFTPSDVEALADLAALVEAEFAAICSSIVDDLTGLYNRRGFHH
LATYAISAARRRAEPLTLAWLDLDRFKQINARYGRADGNIALKAMAGLLSSTFREADVLA
RYGGDEFAILFANSDEKGAWIAMQYLTEQAAVWNEHAEHPWALSFSWGVSEFNHHRDDLG
SWLRTADEMMYSMKQQRGTGGGDKKIL
>A0A3T2WD18|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Orion|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTMSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5Z2PZ51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVTPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5V6FA20|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSLANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A443VTW2|diguanylate cyclase|EC 2.7.7.65|Raoultella planticola|TrEMBL
MSDESKKYISVIFKEWLPLYDGLKPEVKAILKNIAAEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKDQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDHQTGLATIHYAVMAINMAIEMMCHAYTLSHYRATKNEEAFRLYSLM
DNVPMEYGKQQVSLSGWENSAIFNIVSENKSDINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLITQVDNLIAGWKSSDSSAEYKNTQTLLQSIHIHCQKISSQLGVIFSSLSQMQN
GKDTLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDNWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSAGFAVHTGHPDYNRLLRNADSALYVAKRSGRDCVKMHQGEQDPQH
>A0A708P5Y0|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A743VQF4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTHQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5Z2H0X3|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
ILYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A5D1ZH48|diguanylate cyclase|EC 2.7.7.65|Salmonella enteritidis|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A603E5U7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Worthington|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAVG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A4R6ELK9|diguanylate cyclase|EC 2.7.7.65|Scandinavium goeteborgense|TrEMBL
MHHVTRVENPRWLNRLSRHSNPGRVVNVCFFIVLLFSTLLTWREVRVLEDAYISSQRNTL
ENVAHEFNNQLQINIDRLTFYRNGMQAALRTPLTFEGINRADAEFQRKRALHQWSISLDN
RRTLPVHGVSDTFVTETTLLSRDNALLGNELSAALEVGYLLRLSTTLKRTTQQMLYVSRA
GFFIASNSLGSNDDTVEQYYGLVTSPWFIDQTEHNNPQRGIRWLSWMADMPKGEERRVAV
SLPLDYEHYWHGVLAIEFSLAQMKQLLFTATQGEEEGEYRLYDRKMNLLASSLSPGVTPS
PLSEPEKAQLAQAFEHDVRGGLRFTTRYVNWEKIRNFDGILLRIHNLDEGVRGDFGTISI
ALGLVWMLFTSMLILAWVVIRRMVRNMSTLQESLQWQAWHDGLTRLYNRSSLFDLAGKAA
KQNEAQGQPVSVIQLDLDYFKRINDRFGHQAGDRVLTHVAGTIGAKIRKTDLAGRVGGEE
FCIVLPDTSREEACAMAERIRVRISSREILIGKSETLRISASFGVSSSDEKGMFDIEYLQ
SIADGRLYLAKQKGRNRVCCQDDDSQ
>A0A853SML6|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MIAITRPLQRLARRLYRLSLVPLFALILLLALWAAVFYQVGQERASAVRDAVAVSQSLAR
TLADHTSFTLRQTDHATQLFKLKYEETDGGLRLNEFTRRQGLLDSVLPSKLELPIALIDA
HGNVVDSAHAYLPENLAKQAFFRALAANASDTALVDTPMLDAESKRWTIRLARRLNDAQG
RFAGAIVILVDPTYFVDDYDRLNLDEQGALMLVARDSGLTVGRIGEQLILSDRIDFRMPG
PPQHAPEELLIEPPVDATSRIYSYHELPRYPLLAVVGVNRAVALARFEHRRLVYVGALLA
ASVLIAGFTTLLMRQSARLRRSIRQAKETQALLRAAHQGSLDAVLLLKAWRPAPGKPVED
FIFADINERAADMLGKPRSELLGQRVLQQMPLLRGERFFKRFVLVMETGQPLEDEFELPL
ASGGTRWLRHQVVPIADGVAVTSRDISARKHDELALQDNRSFLQSLIDHLPVLVYVKSAR
PENFGQMEVWNKAAEDITGHLATDVIGKTDCQAFPPDFGLHDAEDDRAILAERGVIDHTE
KPLRLADGSLRYLRAVSVPVFDERQQIEHILCIAEDISQRRQQELELRQKQAELAAVNDA
SPLGLVRLDRQRRCTYVNRTFESITGLPRAAALGAGWTSALHPDDYPLMHVALEQLTRSH
APFQSTLRCLQRDGRLVWVSVKIAPILIDDRIEGYVGTLDDITTLRESEVALLESEARLR
TIADTLPAMIAYIDADQVYRFLNIAYEREFGLTGRQTLGKSVRDTVGEARYRTVAPYIER
VLAGETLSFEEEDDKEGIERCMEVIYIPQIGEDKLQVVGFHVMRQDITVQKREKQRLLKL
AQVDALTGLSNRAGFQQKLSDAMHASRQQQHLMAVMYMDIDRFKPVNDTHGHGTGDALLR
AFAQRLTQTMRATDIIARLGGDEFTIIMEQITRPDDAAVLAEKIVAAMQQPFELDGISVR
ISASIGLAFYRDEDISPAVLLQRADVLLYQAKQDGRNTYRAGVLTA
>A0A5E4RH94|diguanylate cyclase|EC 2.7.7.65|Pandoraea aquatica|TrEMBL
MKRKLLSAISLTGRLRLQNLAIVCAVVVLCSGLLSVVWGTYRQASDAALALDALRATLLA
MEKASAERGPANAVLGADLPLPASSVTALRNAREATNERLEELLSALSSDDCNQCASGLR
AVERARLDLAAASANVDLLVQRPRELRSDASVRDAVERMVRVIADFTPVASSRIDIVARG
APGALHYVILARLAADLREYAGQLGSHFTAALTTRQTLTEADQRAIERTLGRIDQLRDMI
GARVNEPPELGPDTLSVLNAQYFGTGLHYVATVRTLAAQPKPPVLTTAEFARQYVPTMRA
ITDLRDSMLRLAQRKVEQQRSTALRWLILTSLAETALVFVIIVAMRNFRRTVVLPFESAT
RFVDELAQGNLDATVPVDGVPMKRSQVRAVFDALRVLRLNAVELVQLRRERARLVGELEM
SSDTDPLTRLMNWRAFERQAQALCAMRTPGHIALIKFDIDNFTQINAAWGHSVGDDVLRR
VGAVCLNTCQPGDVVARLGSDAFVILARVLDESRARQFAELLRGRIEATTLALPNGEKLT
LSASFGIAMADPATFDASVDASVDISIDRAGSRTGAPVSVSALLSQAERQLHAARQAKRH
AID
>A0A517PEE9|diguanylate cyclase|EC 2.7.7.65|Alienimonas californiensis|TrEMBL
MTEALPQTPAARETDVSRRLRRLFETDLLGILFFRYDGGVTEANDAFLQLVGLSRADLER
GAVDWAAMTPPEFLDRDAEKVAELRAAGTCEPYEKEYVRADGSRVPVLVGAAAVDDDGGI
AFMLDLTEQHALRRERDRLAVQKDLAFEAEAVGTCRVHFERGTFEPDDRALAVLRLEGRP
GARPLTAWLDAVHEHDRPGVQEALAKVRDGGWCERQFRLAPEAGTREPQTGEAEVGEAEV
GEAEVGEDPAGRTVRAAGRPTWDGDDRSGPPDGLIATVRDVTESAAVSRRSVLFSELLEQ
TEDVVCVFTAAGVVQSLNRAGRRLLGRSRQEAEGRPVASLYGPDAFQRLREEGLPAAARA
GHWAGDVELMGADGRPVPMLHSLTAHRDVRGELTHYSMICRDITDRVRAEQVAAARQECL
ARLAAGAPIAEVLILLAEAAERLLPQAGRVCIFLRGGAEEGKLPPSSPWGGAAPGERLRL
AAAPSVSDAFRRETDGWPADESGGACGAAALHNTRVIVEDVRTNPLCRDFRGFNDAHGVG
SVWTTNVSAADGTLLGTFAVYHSIPRRPTPADLGVVDPLAHTAAVAVERAAADALAARLN
DDLRRSERRFRGTFENVGVGVAHVGLDGTWLRVNRRLCEIVDYPEEELRTLTFQDLTHPD
DLVNDLELFGRLLSGEIPSYSLRKRYLRKPGGAVWIQLTVALQRDAAGEAEYAISVVEDI
SEKVRAEEALQEMNATLELQVASRTNRIRRQKSKLERLARGLAETETRERRRLAHAVHDD
LQQIIAAAKMSASGLLARELAAADQAAPGDGLSAGSGDNPAEDAHAVPGPAAITVDLLDE
AMNRARALTQELVPTLLYDRGLVPALAALCRRSEERGQQPIRFAAAGGDEPPPANLVDRA
DPRGPLLFHAARELLFNAAKHAPHLPVRLTLERVWGGGLQLVVSNPLPADVMAAQRPERF
DSHRSADECFGLFSLAEQAGLAGGDLSISRDDAAFIATMTLPAPHLSLTPRAMPDPDVAP
PSPAPVRVMIVDDHRIVRTALAGLLSSTEGIVVVGEAADGCEALERVAELLPDTVVMDVT
MPRMDGIEATRRVRDLMPNVRVIGLSMHDRDDMAEAMCQAGAAAYVPKGGPPEELIRVLR
GEDSPDNC
>A0A1C6JGX4|diguanylate cyclase|EC 2.7.7.65|uncultured Lachnospira sp|TrEMBL
MGAKRKIEIRKVSRLGIWITLFLALAFVFLIIQGENEFFAMNESTEQYIQGEKAAQQFEK
GADYLTEQVRMYVMTGDTSYMDAYFVETNQVKSRENALDTFKTYFDRTASFSALKAALDT
SLELMTTEYYAMRLVCEANDVLQSSWPDEIKAVELSKEDEELSDDEKIKKAQHIVTEESY
QEMKDIIAEEVTNCEAKLIRQTRHYQGNAMTIFSSMYSKLQIGIVLMVILMIGSYVMTHL
LIVKPLISYDESIKLGEILPVIGAVELQNLAVTYNEIYVANKETEKLIRHEAEHDPLTDL
LNRGSFDKLIHIYETGESPFALILVDVDVFKEVNDTFGHGIGDQILRKVASVLKKQFRNI
DYVCRIGGDEFAVIMVNSASDKRCTIKKKIEEANEELSNPTDGLPAVSLSVGVAFSDRKN
PKGSISNDADAALYYIKEHGRHNCGFYGQLN
>A0A1D8YCT5|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp. LM091|TrEMBL
MHNVPNLDEASQPLALAWADTLARTPAAAATLLAGLSAESPPGLAHHFYDVLLEDPRASR
FLSHDQVRLRLKPAMQRWLQQILTATPDSINALVAAQRVIGDVHARVGIPVDLVARGARV
LKHRLFDRIIAQADESATAFAAIHCLSASMDIALEGMTLAYTHARERSSRTDAAYRLFSL
VQNVSTERERQRALLLDWENALLYAMASQNAEAELTGLAQSEFGLWFTHKGIPSFGESSE
TGQVGALVAAVDTQLQEALAHADFAARFGALQGIRERLAQIRTLMGMLFERIGELDAGSD
ALTNLLNRRFLPTVLRREIELANSTQTPFSVLLLDLDHFKAINDAHGHDGGDRALQHVAA
LLGQLTRGSDYLFRYGGEEFVVVLVAATAAQAEVIAENLRKHIAQSPVQLANGHSLSLTT
SIGVAAHDGHPDYERLMARADAAMYQAKKRGRDQVVLATDALPDAPGRQALQRG
>A0A6G8S2F9|diguanylate cyclase|EC 2.7.7.65|Acinetobacter lanii|TrEMBL
MDKEYIAQLTEQWMGICEEYSATDLSAAFELIKRHSPEFVSEFYKLMMAEQNASCFLTDE
MVQSRLRSTLNTWLLDSFEVPFKQNFEDIVKKQLVAGEVHSRIGVPSWLIMHGMRQIKKK
VMQFLKQDQVENALAVADYIVQILCFASEIMCRTYEAKVEVHNDVKHSYRLFSAMQDVAV
QKDKQRGSLLDWENELMYKVFSDNTAIIHSKLSKSEFGLWFIHKAAYAFSSSDQVEVIVD
LIHKVDDLNDQIIGEQNRSDALTYIQRIREKNRQILLLIEQLFQVAEYINSGNDSLTQLL
NRRYLSTIVSREINLARKSQSSLTLLAIDADFFKKINDRWGHGAGDQALQMLADVIIENT
RGSDYAFRIGGEEFLLLLVDTELSQAEVIAERIRRRVEESTVSANGGIHFSFTVSIGIAK
YNGHPDYQRFLDAADTALYAAKHQGRNNVYSV
>A0A377QGN5|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium lividum|TrEMBL
MFTSRSLSPAFYYLFFSGEREQQQRFFKELHFISIAILTFGLACWLVTFSLTLPRASFDH
AQAALGVTGMLGGLLLTVYAKSLQAIIASGTISVLFIAFGFRVLMLSTEDPAFWVLPLGV
MITLTTAPIFSGIAYYLGVSLCVWAMLGLGQFPVHAGQADQHWPVLAVTISVIIGLALNI
YFLVLRIHNYRAQRELATMAYKDGLTGLNNRRMFTQGARTLQRTARTPAYFLMIDIDDFK
QINDVYGHDVGDEVLKKIADVIAKLSGEHLCGRLGGEEFAVIYLGEKNAACAFAAQLVDS
VEAAFVPERKVSVSIGVAELLKEADLSHSYRRADESLYQAKKSGKNRYVLNAA
>A0A4R5LLW5|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia guartelaensis|TrEMBL
MLCSSRCPETRRRAPPHRDARASNRCPGGFMQHTPGRTRPHGFSSMVMRHPHLVVTVCFL
AAMALVSGVGLRQLYQMTRYDLHSRQRDLEVRAVGVDALISAERRRLLFLRDYAEHLLAS
PSQQRVGLQNPKVQAALRDSDQPQWDAPGAMDGPRVFGTNAQGLAGIDGFDRDAAALPAD
IVLARSISPLLAISQHADALQSTVAYISANGLYVLSPERPDAHAPDLLRRFSTMPYYRLH
ATGQNAGHDIVWTPIYTESKKGEAIATLSAPVYTNGRFRGAVVMDVAPSRLLSLQLATSN
LTDDDSPVEFGLLNSNGDLVYFVDGKITSQRPARFDPYLLDMARTQAAAWMARGQGYVER
SGRYLLFQHVGESHWILLTDTDDSELTLAAARRVFSSPLIVAWLAIAVLLIGTLRVVKHI
FGQYVEASTRLETLARSDPLTGLANRRRFQEAFDETLERAARESGDEATTPAMALLMLDI
DYFKRVNDRFGHAAGDRVLVIFADILRGNLRSAEMPARVGGEEFAALLPGADLATAAAVA
ERIRQAVEAHAANAAQTASMPGEAVNPDAIAFTVSIGVAASPADCPAHYEALMQIADRRL
YAAKESGRNRVVAEDSRSIDPARA
>A0A7G1PPN4|diguanylate cyclase|EC 2.7.7.65|Citrobacter koseri|TrEMBL
MPHETTPGNWSWLRTLARRFGPGHVVNICFLVVMICSTLLTWREVVVLESAYRASQRNHL
ENVANVLDRQLQFSVDKLLFLRNGMYEALVTPLDFADLHDAVAQFAQLRGKSFWQLELDR
RRTLPLNGVSDAFVNRTTLLSRDNDALANELSAALELGYLLRLAHSSTMLAQRTMYVSRS
GFYVSTEPTTNGGDIMSRYYQYVIQPWFSGQSQRQNSARGVRWFSSPVPGGEVQQKVTVS
LSLDNERHWYGVLAMDIPVSSMKRFLEDAVEKDSEGEYQLYDYQLRLLATSTPEKRQVNT
FDDLELALLANDIEHDTHGGIRMGSRYISWERLDHFDGVLLRVHTLREGVQGAFGSISIA
LGLLWALFTMMLLISWVVIRKMVSNMFVLQSSLQWQAWHDPLTRLYNRGALFERARVLIQ
RCHEQRQPFSVIQIDLDHFKSVNDRFGHQAGDRVLSHAAGLISGTIRSHDLAGRVGGEEF
CIVLPGTTLVQAAQIAERIRQRVNDKEILIAKGTTLRISASLGVSGAQENGDYDFEQLQS
LADRRLYLAKQAGRNQVCVRDDHPAPSPDTR
>A0A0X8HFT2|diguanylate cyclase|EC 2.7.7.65|Halomonas chromatireducens|TrEMBL
MKDKEDKAFLAQVAALIDASEHAGHPLHDALQRLYQRHCEQQVQIQRLIDISDRYQSLAM
EARQVTEQRYQRTLRRQQKLSRISDGFQALIQERNQALHQASTHDPLTGLPNRRLILERL
EAFVRERRRFTLTLLDIDHFKRINDCHGHDVGDQLLMAISHALSEALRDYDVCARWGGEE
FLLLLADTDRNEASTIVERLRSHLAEVTIRAADEKISVTVSAGLCQHRPGEPHQTTLKRA
DKALLKAKQAGRDRSLSDAF
>A0A8F9YAN5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MSRDDVQRWKDKYLENIEQQECLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
AAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>A0A8G4B6P9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MFSGKTDDRGLWAGIQAGVLFFLAALACIYLSRQPATIAAIWLPNAILTAALLRAPLRQW
PAILLCSAVANLAANRLYGDSLWMSAAFLPANLSEAIFAAMLLRINRVREDFEFNLHSAV
RVLWAGALIPPLLGASVGAVLVSVFGMGRFPEMWARWYVGDAMGMLALLPLCMASNLAAW
RHALSGRAGVDNAMLLLVTLVISFVALTRLPYAFIYVLLPLLVAAASTSVFGTALIGCLN
TCFIAVLIALGVFVPESSQQRFGEPLLYLPMALTLIPAFLVSVIMERSRREQHQVAIGEA
QFRGAMEFSAIGMALVSLEGRLFKVNEALCRMLGYSAERLGELSFQEITYVDDLELDLDL
VRDLLAGRINSYQMEKRYLREDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKRAEL
ERERLAERIKLATDAGQIGIWEWDLARNRLHWDFRMFDLYGIRSGPGETTVEQWKASLHA
EDHDRVLRELERAVSGLQKFDCEFRIVRPNREVRHLRAIATLTRDEDNRPVRMIGINSDI
TEIRTLAETLHEEKERLQVTLYSIGDAVLTTDAGGRXTFMNPVAEAMTGWTLQDAIGAPH
ELVFNVLDSDTGEALESPVRRCLQNTRVFYLEDGATLISRKGEQHDIQNCAAPVRTRDGE
IIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALC
FIDLDRFKVVNDSAGHAAGDMLLRELSRILADRTRASDTLARLGGDEFGLLLFDCDLAEA
EQVASKLIEQICSVRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGR
NRVSVYQFGHEEVERQHRDILLASGLREALENDRFQLQAQEIVPVGPRRDGDRHYELLLR
LYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEGLSIGINLSGNSL
NDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGS
GLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDSINQIAHRLGAVTVAEFVESREI
LDHLARLGVDFAQGYAVGRPQPFATVLDQLRSGLRRQELG
>A0A485G1Q2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MLALTLLANLPIAIGLAVQRWRQGSATARLYLVGFGLVLGSVSLGVMRATALVQPTSANA
MVFPLALTLEALLFSLALASRIQDLKQERALALDQADQEKNARLALLHSAQRDLARAVEV
RTNELSEANRQLQMREAQLQYAAHHDPLTGLGNRRHLMEFAESALDDARRHGNSMALLLI
DLDHFKPINDTHGHDAGDFVLQNVAQRLRHCVRTEDCVARLGGDEFAVLVGGSNAEQHAR
DIAERLLRELAKPVEFAKQWLVITPSIGVALFPGDALQFGKLYKAADQALYRVKGAGRAG
YAMAADDERETAPALPWPTALAPERIS
>A0A5S9QYT9|diguanylate cyclase|EC 2.7.7.65|BD1-7 clade bacterium|TrEMBL
MTLVDKRILRVTQALVLAALAPIGWMLLQYLMGIDVYATIRENNLVYWYMFVGSALAFVS
FGFYVGTNEMHLESLAITDEATELHNERFFKQRLPEEAARAARLRQHFSLIYISLDHFAD
INSLYGRGVGNSALKLIANAISGVARKDEIIARVGEAEFVVLLTDCSQGQANIAAARFLK
CISDVVFQVEKGKQISITASIGLISSETNNSDEWQLYAFAETAMYRARRDGRNQVAAYNI
D
>A0A157SWE1|diguanylate cyclase|EC 2.7.7.65|Bordetella ansorpii|TrEMBL
MPRGRLARWLTAPGQPTPHEIRVALVGTLFGTLPIFFGGVFNTMAVAGILTYRHPTLPFR
FWLVAEVIVCLVRWYVLVVSRRRAVQGRPTPTDLYILLAPVWGGTVGYGAFVSAVSGDWV
AATLSFLSAAAMVGGICFRNFAAPRLVVVMIVFSLGPCCLGALAAGEPVLLLTLLQVPFY
LFAMGAAARRLNGMLITTMTAEREHSHRARHDALTGALNREGLSKALEQRGAEPGKKDMT
LLFLDLDGFKPVNDAYGHEAGDMLLMQVALRLRALASPQALVARMGGDEFVVVDEVSEGQ
AQHDLAAAIAESIRHPFSLSHGVVATVGVSIGSASVKWDGTDIDMALRLADTAMYEAKRT
KKTEPAVNVGSDAIQFADRDRQPP
>A0A6B8MU47|diguanylate cyclase|EC 2.7.7.65|Klebsiella oxytoca|TrEMBL
MKDESQKYISIIFKEWLPLYDSLTPEVKAVLKNIAGQQAEALAARFYDFIFQDPDIARHL
TYDLVQERLSSSLALWVKDILMSEKENLPALAERQYQIGSIHSRIGIPAEAVLRGARQLK
AGLIENIRDSNLDRETSVAAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPLEYGKQQAALSGWENTAIFNIVSDNKTDINGALLSDSEFGLWFRHKCVRYFNKNPQM
QEITDLISKVDALLSAWKSSTDNSEYKNTQALLQGIHIHCQQIGSQLGVLFSSLSQMQSG
KDTLTSLLNRRYLPVVLKHEVTLAMEYELPMTVAIIDIDHFKDINDSWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGAAEAFTILERLRKKISQLAFSVGADNEISI
TASIGYAVHSGHPDYNLLLRDADSALYVAKRAGRNCVKKYEGEGN
>A0A836NDR8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 2-460-02_S1_C1|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A173ZHE0|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium adolescentis|TrEMBL
MTVVTLFNIAMELWGVLICIVCAGGVYVGAIRRTRRTYTKVSMQLLCALMLLADVSAWYH
NGGRDKLDFYMTRIGNLGEYLINFIFIALFANYIWQTVSGDDMLENVSPHEWRARTSGGA
KRNRKNQRSANAQSKPKKPRSKKLDVIYAASALGIVLTIAMQFNHMVYYIDSQNYYRRGP
LFAIPQILGLVELALIVMLIIENRKNLSRPLFVTSLSFFVLPIVTTIVQILHYGLALQAI
AITISIQFTFVVDTIEMNKKIRSQDDAYQKASYEAQHDGLTDLWSKSAGREQIENYFAHM
QEGDQAVLIFVDIDDFKQINDTYGHKVGDFWIREVAQTLKRLYRHDDIIVRFGGDEYVAL
IKNTANERVIESTLDLFRRQLAQASAQYGQDVHCSIGACRVLSGKNVDLNLCLGFADHAL
YQSKREGKGMYTVVDYDSGKVQAA
>A0A729QPF5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kouka|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
GLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F7MLE1|diguanylate cyclase|EC 2.7.7.65|Klebsiella grimontii|TrEMBL
MARHNRKLSFTTPIVIGFAGILISFLLIAVFATMTQRKDFLEDYHHINRNFTHNMATNYT
ETLLRGNDFILTRATTFFARNDELNNAVNVNPEKGLMQLMQLQNMMQTVSSISLADTNGH
YLRAPEVLETEDSQSFDAKSRPWFIKQAQASTFSLYTSPYIDYFTHHPTITLYKPIISPE
GRLKGSLAFHLDLTSMGYALRQMVAPVQGEFFVVQRDGKVVLHPDPGALFKPYVSEALMD
RMTSGEGQLYDAVTDGWYYYYSFTNPDWFVIYRVDNSTLVNLTRHETDIVAWSFALAAIV
IVLFGLYLRHASRTVLMNIINAIKTGDVQRAPRLEAMLSKAIESNKQRELTYVRQATIDA
LTGCKNRRAFDSDIAALMNDHHPFALALVDIDNFKTINDTWGHLNGDIVLRNVAREGLQI
LQPLQISLYRYGGEEFAVIFSDEHIDNALVLLESWRASVAQRSWREEGLTVTFSAGLGEW
NMEPLEQLVVRVDEALYKAKQQGKNRIVRT
>A0A8B6KT77|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MALHPASFDDHIFRLLIEAVDDYAIYIIDAQGHILTWNNGAERNTGYNADEIIGQSFELF
YTPEDLATQLPAKGLLHANQLGHYENQGWRVRKNGKRFWGHITLSALHDSDHNLQGFVQV
TRDLTDKWQRENALRKSEEQFRHLISEVEDYAIYMIDTHGRILTWNKGGERNEGYTSDEI
IGEHFALLFTPEDISAGLPEKSLAKAIAEGNFQTEGWHVRKNGIRYWASVAINPMHDDSG
KLLGFTKIVRDLTERRQREEALRISEERFRLMVDTVEDYAILMLDPWGRVNTWNHGAERN
MGYASNEIIGQHFGCFFLPEDIAAGLPEKLLKTSASASRVEREGWLVRKDMTRYWAVAII
TVIHDNSGKLLGYAKIIRDMSERKQREDALRASEIARYEEREQLHRVLSSIQEGIISLDT
EGRVVLMNPKAEEMTGRSQNESCGLPIEDVFILWSPLQDKNQLVAINQCLAEGRHTLLPE
GSQLLSSQGERQEIRCSASPIRDRDNLLTGAVVVFQDVTRARHEQRELQYQANHDMLTGL
INRRRLEERLNQAISQLGQDEQHILCYVDLDYFKDVNDSAGHEAGDMVLRMVAQTMQQAV
RENDIVARLGGDEFAIVLFNCQNKPATEVLERVVADIASIQFHWHGQSYSFTASLGAVSL
NRQTETAAQAMRQADIACYTAKHAGRNRLSLSL
>A0A3S5DI02|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica subsp. enterocolitica|TrEMBL
MPYSSRINTRRSGLSFAKRTYLPRAFGLGIGMFCVGSVLYTQNAPLWLWLMLVLNGLVWP
HIAYLLASRSEQPFEQEIINMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFKPETSPLQVYACLPMIIIYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDEAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLMRIQERLADLVF
TQAPPLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A2M9MWH3|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. GM2FR|TrEMBL
MNIPKKRIKISLAMVMPALVSLSILMTMSIMIYIQYKNEKRSLYNNTMSLNLSSAQKMAV
TIEALLSGMRQSLRASANNPAIEASAASDEKELQVIFDLMLQSSLYFNSVFWADQAGTIR
VVSPEGNHLNPARLITEGTTKALNERKSYISAPYRSPTGRWMILASEPIFDSSGKYHGMI
AGTIYLEENNILHRIFGSGAGNEKDSYSYIVDSGGKLLYHLDKSRVGEDVSSNVVVQRLM
DGESGMQRVMNTQGNDYLTGYASVSMNGWGIVMQTSVSSILDDVNRNLQDQLRSMLLPIM
IMLVIAAYMATRIAAPFTQLYKLTKSIAAGQTVSSEEFQPHWNREADQLNQIMGAAAETL
AKQAYSLQQEASTDPLTGLTNRRELERCLDSWDSLGDPYAVLMLDIDHFKNVNDTYGHQT
GDQVLKLVAAVMSGCVPAGAVCSRFGGEEFVILLRKHSMEEAYRMAERIRNAILISQTPY
SLTLTVSIGVSLYPEHGGNREDVFQAADMALYRAKDEGRNRTIAAGLSA
>A0A0M9I5X7|diguanylate cyclase|EC 2.7.7.65|Alcaligenes xylosoxydans xylosoxydans|TrEMBL
MRINLRGLVLALTVFSAIAATANALYASYRLQREQLIANTLESNRVYAAKLAESAGGFLK
AAQRQLGYSARHIAAHMDSPGLLAAEVLRVQEQSETFNSVGVVGADGLILATTQNFRSFL
GTRVDSPGSRAALQARHPAISKPYVSIAGNLLINLSYPIFSTDGRYLGYVAGTLHLRKES
ALEDLLGRHHYTDGSYLYVVDGDGRLIYHTDPARVGEVVTGNPVIEAVIEGQAGARRVTN
SRGVDMLAGYAPVPASGWGVVAQRPTAVTLEPIRDLLWALLGYAAPLAVVFLLAIWWCAR
QISLPLSQLATNVEHHDVAVAMQRVKSVRAWYFEAERLKRAVIWSFTSLQEKIGKLNLAS
ITDPLTGLRNRRGTQDAVDHLQAAGTPFAVVALDIDHFKRVNDTYGHTVGDKVIQDVAQL
MRDCSRPSDILCRNGGEEFLILLPGVAPTEAVIVAERLRQRTAEREIDLVGGITVSAGVA
QWPTSGPEVLQAFHAADAALYAAKQQGRNRVVLHGTP
>A0A1E3GVV7|diguanylate cyclase|EC 2.7.7.65|Methylophaga muralis|TrEMBL
MMQPPSEAKTESTNLTGNELLKHLSAVSPYLPGFIYQLCLTPEGRFYYSYTSPRVESLFG
VTQQQLAEDASLLLKMIHPDDYQRVINESIESAESASAWHSEFRMLLKNGRIIWIEAYDT
PIREADGTIVWTGYGNEITQRKNYETALNESETKFRAFVENANDIIYSLSLDGTLTYASP
NWSEILGHPLTDVIGRNFEHFIHPDDISACHSFLQQVRHSRQKHSGIEYRIQHFNGHWCW
HRSNVAPLFDRNGEVNSFTGIARDITEHKLMMQRMSYMAHHDTLTGLPNRASFTEHLNQA
IVLSQREEQAVAVLFLDLDNFKPINDQHGHAIGDLLLQQVANRIQQCLRGADVVGRIGGD
EFVVLLQNVHHVANAQNTAEKICECLSIAYEVDGKILHIGVSIGIALYPLHGNNAMQLVR
YADEAMYEAKKLPDRIQVFASPPLGVGSNKHEETMPDDLSAKMADDQQ
>A0A5E4RYN6|diguanylate cyclase|EC 2.7.7.65|Pandoraea anhela|TrEMBL
MSHTLPKPHATDDADDIAHAAQTAQHALARWRTGAADLQGIDGISDLGGAGDSAGMTQSK
GSAAGAVPSRLPSDFGRGRIDSVTDVFDRESTWLRAQSLAPCATPGPSVKPAFVRQHVER
DVQPEQHVLFGTLESFEHFVQLPDPRPESVSSALLSSTRWALPYRRDMTASDADSPDVNR
ARLSPQRQAASSLTRSTGVGLDEAERLAALRRYEILDTPPEPAFDRIVRLASHILGAPIS
LISLLDESRQWFKARRGIDAPQTPRSMAFCAHAILGDDVLVVPDARADRRFADNPLVTGD
PNIRFYAGAPLRTPEGHRLGTLCVIDRRPRDLDEEKRGLLADLSSLVVDELELRRVNRVL
GDMAMRDGLTGLLNRRAFLMQAERLFALARAQQRRLSVLMLDIDHFKVINDTWGHAIGDR
VIVELTLVLRATLRKSTVIGRLGGEEFAVLLSETDAHRATQAAERILAAVNGASVPGPNN
ATGPVRFSASIGVGSITPDDTDFGTLLQRADRALYAAKQAGRNRVAAL
>A0A212J7L9|diguanylate cyclase|EC 2.7.7.65|uncultured delta proteobacterium|TrEMBL
MTNTESLALNLLQSFNYAILQRIGPKKYTFFGQAPAFYNALFPPCADGPCTTPWETSPML
DFFLEEAEAFFARKELGALASGIWEEDGITQKDTALMALAKNLGETQLIVIRLLQEDYID
RVGILRKAREQLLENRQLSQNLAMFKEKSRIDGLTSIFNRATFMELLHDEIKRSQILEYP
LILLILDIDDFKKVNDTYGHLVGDKVLQGMGATLKASLRRNDIVARYGGEEFAVLIPHEA
MDRALQIAEKVRKNVAAMVIPDAPPITVSIGCTAYSPGEASESFFKRADEALYLAKTTGK
NKVCIGR
>A0A142XB51|diguanylate cyclase|EC 2.7.7.65|Gemmata sp. SH-PL17|TrEMBL
MESRHSRWRRWAVVPGLALVYAATARMGLALGLPPDHKVTAIWPPSGIAFAAVLIFGPRV
WPGIWLGAVLANVWDAFTPVGAGAFGAHLGAAIAIASGSTLQALAGAQLVRRAAGAVPPL
DRARHVFRFVALVPGACLIAATIGVTALCTSGLAPWGAFGTLWWTWWLGDAVGVLVVAPV
LLTWGRPRAPGANRPGAGEAVGMFALLLGASVLAFGGWEHTGARASPLAYLSLPFLVWAS
VRFGPRGAALTVVVIAAFAVWGTVRGTGPFVRADVYESLLLLDVFLAVAVVTSLVLCAVL
RERADIEAALRASEAQLRNLAEAIPQIVWGTTPDGAVSYLNQQWTEYTGLTGAAPDDLAR
VVHPDDLKRLLGAHADARRAGAVFQSEFRMRPVRGGEYRWFLVRSVAVVGPDGAPAGRIG
TSTDIDELKRAQAELVRQRADLQLILDTVPALIFHKDRDHRLVRVNNELVRLVGLPREAL
EGRTDAEIGSPHAEQYRRDDEAIMTEAREVRGVIEPLYTLAGTRWLQTSKLPYRDATGRV
TGLIGFSVDVTEQKLAQDEVRRLNAELEQRVAERTAIAEARATQLQRAVGALREQKQLLQ
TVLDSLGEAVLVVDKNGKFLMQNRAFRQLHPEPTEHLSPIERARVNGVYLPDGSAPCPPD
RLPIFLAMRGESCDDVELMTVSNAHPDGIPISVTGRPILGPNGVEGGVIAIRNVSDARTA
ARALRESEKRFRAIFDQTFQFIGLMTADGTVIEANRTALAAAGLSEDEVLGKPFWETPWW
THDPVQQDRLRDAIARANRGETVRFVTTHRAANGELLWVDFSLKPFHDENGTVTLLIPEG
RDITAIKRSADALEAADMLLRQFIKHAPAAIAMLDTEMRYVQASDRWLTDYHLTGQNVIG
RSHYEVFPDIPERWKRIHRRVLEGAVEMCSEDPFPRDDGNIEWLQWEARPWRKAGGEIGG
LVFYTQVITDRIRAAEALRESEERFRSAFDAAPIGVALVSPEGRWLKVNQSVCALVGYSE
AELLTIDFQTITHPDDLGADLALVEQVLRGELASYQMEKRYFHKSGHVIDVLLAVSLVRD
ARGEPLYFISQIQDITERKRAEARLLASVHEKEVMLKEIHHRVKNNLQIISTLLDLQADG
ITDPEALAAFRESRGRVRSMALIHERLYRSENLASVEFGTYVLNLAEDLFRAYRADDEAI
RLTVSVTVPPVPLDIAIPCGLLINELVSNCLKYAFAGREGGMIEVSLVRAEPGTNVLTVA
DDGVGLPPGFDFRQSTSFGLQLANTLVDQLGGEITLNGTGGTRFTIRFPARG
>A0A8H9E0G5|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVAIALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KMCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8I0FPZ0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. C1|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCHFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYDCVV
PEDREHAESVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANRVLNKDGEVERLLGINLDM
TEVKQLHEALYQEKERLHITLDSIGEAVICIDVDLKITFMNPVAEKMSGWSQESALGIPL
LTVLRITFGDNGPLMENIYSADMSRTAIEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVISAINDYHFTWEGRLHRIGASAGITLIDDKNRIATEVMSQADIACYAAKNSGRGRV
CVYEPQQSQMHATRGILSPDEQRNIITHNPILMITHGVASPRVPETFSFWLLSLRLWNSE
GDVIEEQAFRAGLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLALMENSPLPPRLLHLSIPVDVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLEVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A823BA49|diguanylate cyclase|EC 2.7.7.65|Shigella boydii|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
LVIFSSNYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A2N9M4X6|diguanylate cyclase|EC 2.7.7.65|Burkholderiales bacterium|TrEMBL
MRPMKKLQNVAICSATALRTMAQFAALALAPLIAVAALLHSQSSLTASMIETLQNVAIGV
VVLALALGAVQGELIARRLQRLISSAHSIAKQDFSVALPARGGDELALLTRAFNDMARTL
GTSLSIQGILAQMDDAILTKLDVAALIRNALRCMRYVAEADIVVLGLFESDAADTMRLFV
MGKGERNRIDSHKIEMSGDLKRRIPLSPTNKTEPQSPFPEEFEQRLLADCGVGHFLSMPV
SRGSRAWGVMVTCHREPRELSNGQMKMLIGVSNRLIAGFSGAERDQKLHSLAYVDPLTGL
PNRVAMQSLLSAELANAERNKAMAAILFIDLDRFKQANDTHGHAFGDRLLIQAANRIRNH
VREDDVVARIGGDEFTVILSEVKTTREAASVARKLIQSLSRRFEIEGQTIYTGASVGIAM
YPDDGTGGAELLKMADTAMYRAKSAGRSRFAFYEEPMNAESKRRSLLDGELRNALERKEL
VLHYQPQIDLKTGALCGVEALVRWQHPTRGLLYPKDFIEYAEEIGLIPQLGAWVMMEACL
QYQRWCEEGVRVPRVSVNVSNGQLPRSNFVPTVRQLLHSIKIPAGALEIEVTESMLIEGG
KPAMEALNQLSADGVLIAIDDFGTGYSSFSYLKTMPARVLKLDMSFLVDARSDNEAGKIV
AAIINMAHELGKEVVAEGIERVDQLKLLKHLGCERGQGYLFGKPVGADHISRTFGKVQES
APPAPIAAAPAPPAVAVAHSAAQADAHSDLFEASARQASLHPAVPLAAPSSTAQDKHSTL
LLPAPLSPAADASATDAGQQEQPAEQPAHAPSQAVRPTPPGQTSLDLVPPASEVDATVET
VLAIDTWPVPSEANVPTTEELLQATAALLESETHEPAQH
>A0A7U6Y3S5|diguanylate cyclase|EC 2.7.7.65|Rhodospirillaceae bacterium LM-1|TrEMBL
MTIANRVGALVAAALIVFLAIDAFVLHRVVFPSFEGLDDMHAREDMRRVRAELENELVLL
DRFATDWAAWDDVYAFVQDRNNAFIAGNLETKVMFEQRLALMWFVDTEGRTVWGRALDPN
NSAPKPHPLFPGQQLPLDSPVLALKEIDIGLTGFIETPLGLMLIASRPIVTSHFQGPLRG
YLIVGKLLDDRHFVALSKRTGSQVSGLAAALISRDSEDARLLSVLTPGDIRLSLDSAGDK
LIATASLYDLSGHPAMLLKTTFDRQHVKLGRETLNVALLVLAISGAALMGVVYVMLHVYV
SRPLKHLAHDIKYLGKASLDAGEDVPDGLGEVAAVKQEVKGMLDRIAYLSHTDSLTGLPN
RASFNLRASHALALARRHETRSAVLLLDLDGFKEVNETLGHEAGDRLLLAVSERLKGVLR
ESDSLARFGGDEFLIMAENLPAITGAADLARRILDIFKQPLIAEDIRHGRACSIGIAIFP
DDAQTLDDLLRMADIAMYRAKSSGGNTWRCHAESLECRGESSEQQ
>A0A486TU19|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A3D1C1E3|diguanylate cyclase|EC 2.7.7.65|Shigella sp|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDYFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A5Q1D8I5|diguanylate cyclase|EC 2.7.7.65|Bordetella parapertussis|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVMRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKPGGRNRCVLANAGPAEPSQRPDAVSQSGQH
>A0A1V5QJ70|diguanylate cyclase|EC 2.7.7.65|Acidobacteria bacterium ADurb.Bin340|TrEMBL
MLDIDHFKRFNDSFGHEVGDRVLALFARTLQARLRSGDLVARYGGEEFTVVLPGAGAEEA
RVLAERLRAGIEALELVPPEFPEGCRITASLGVATFPQHGHEAEALLQAADRGLYLAKGQ
GRNRVVATPLDNPGTGLPS
>A0A483M316|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae|TrEMBL
MDKPLRLKLKKCYHLARPGHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALGAPWFTRQTQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSTPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>A0A4Y7RK20|diguanylate cyclase|EC 2.7.7.65|Pelotomaculum propionicicum|TrEMBL
MQAKKRNWAINYEKFVPALRILTTLFIMAVFYNRFRVDIYIAFAIYLLYAAAKLSLGGIF
KNFFTKNKTLDIFFDMLFISSLIILTGGSSSYLWPLYLAPVISFTFTGGGRSGILVAAAG
TVFFLMAVYYSELSLKKVPADFLLAIILVASLTYLLFYRYKKAVLKMAATDSLTRTFNLG
YFQECLDRAVENYETTKEPVSLLFIDVDDFKAVNDTYGHLRGDEVLRAIGEAILLAVRKQ
DLVFRYGGDEFAVILQNAAKEDALHVAERIFSNVKRSVEGLTTFMKVTVSVGIAVLDQEF
TDKKMFLEAADKSLYEAKRLGKNRFAIHSQTVMDRTK
>K0PZ64|diguanylate cyclase|EC 2.7.7.65|Rhizobium mesoamericanum STM3625|TrEMBL
MRGLINAIDLPRPETRDPGPGKCADQADLQDVLAELASFKTALDPHTIVGITNRTGTITN
VNDRFCQISKYSRLELIGAKHSLLNSGHHPPAFFQEMWRVISGGARWHGEICNRAKDGSL
YWVDTTIAPKMDASGRICGYVSTRYDITQRKQAEKALNDENLRRERVEMLLRDIIETLPN
GVAAYDENDRLILFNSGFKECYRRAGGAIAEGRRFQEILEDAVASGEFADLSCADDNWQN
WINARLRSHRNPGRAFLQAVSGDRWIKVQERRSASGYIVGVQTDVTDLKRAERQVKLQAE
ADPLTGLLNRRTLIERLTAILSQKAERHSALVLIDLDGFKAINDMHGHGAGDALLIEVGK
RFRDNVRKSDIVARLGGDEFAVLLVDVGSKANAIRIVRKLLRSLENPVRLGRKAVRVSGS
FGLTIVRKSKSATPLKVFKRADIALYQAKHNGRSTYAVYNTDMERSIRRREAMIEALRRA
IAQGEIQVAMQPQARFVDRGHAGFEALVRWQKDNQWVPAAEIVSLAEQSDLICALGRAVL
AGTLNAMCEMKRKGFAPGKVAVNVAAAQLRNPNFAKELLDAVSAHGHSASEIIIEVTEGV
ILDRTSEAIGVTLNRLFEAGVKIALDDFGTGYASLTHLQRYPVSYIKIDRSFVRDVGHDH
GCHAIVGAVTSLAHSLGMEVVAEGVETPSQYQSLLQTGCDYAQGYLVAKPILVEEIDTYL
RNCEANRPVFTFVA
>A0A2Z2P722|diguanylate cyclase|EC 2.7.7.65|Granulosicoccus antarcticus IMCC3135|TrEMBL
MIGLSGATLRQMLTIPYVALVLIAASIIGLLSYLAGLNAVNTLSNYALSETVSRIAQAVD
KHIEGSEAVLETAFPTDMLPPTSVKDDLTALRTRLWLATTIHRNPNNYAYYGDKDGQFIG
LYRFNETDAELRLRTNGESPRSIYTFSRIFGQLGTPVTEERIFEPRERPWYKAGQSTTEQ
TWTAIYIDFKTLELVSTRARRVNNAEGEFQGVVATDVSLELLNDFLRSLTLTPNGFAFIV
EPDGNLVATSRGPHIQTGVNNDNSRLNAAQSSDPLLAAAFQSLRKQSEPHSPQTKPMTSS
FEGPDGKIVQTGYFMLRDSAGLDWTIVVAVPRSDFMHSVEQNVQRTAWLSLAVCALIALV
GLVVLNIISRDLRQLAKAAKALGEGNKFPNIPVHRKDGIGELARSFAAMQERLLTDRLTG
IPNREAVIRRIEDRIIQNRRRRDSLPFVVMFVDLNGFKAINDRYGHEVGDRVLVEVSQRL
EASLRLDDLAARYGGDEFIVMLNEVSDRNDAIKARTKLEIVLAEPLQSLAEFGETAAIMT
TGAAIGLALCPEDGNDLDTLLNHADQDMYQRKQITSKTPV
>A0A729WI33|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar 4,[5],12:b:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIALWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8G1PY65|diguanylate cyclase|EC 2.7.7.65|Pantoea ananas|TrEMBL
MRVKLFEEHNAKKSALWLFMITLMFCFVGGHLRIPDDLSLFWPVNAFIAGMMLRYPFLHR
TRFYLVCFSAMVFNDAVFSGWTLPAFTLNVANILFILICVVVMGRQYQHDSSSERIANAM
RIFPACLLAAFGCATWGGLAQVGSINAEFADAWMNWFSEQFSTGLMLLPFLLTSSWRVRI
SARRLKMGKIVPLIAVVLSVVAGALMGGAGSLTLPVPALIWCAIVLPVPLTSLITLITGI
SQIILVSHGVMNIQGDNSLLPISHLTSARLGVATIALSPLIVAVSMDAIRQLNERLALRA
DYDFLTQLLSRSGLYEHLRNEACSEQRQVGVILLDVDYFKSVNDNFGHDAGDRVLEEIAR
RISPLVGNHGHICRFGGEEFVIVQFDLSPEMIYSLAEGIRQSIVKEKFLLHGNAVTVTVS
LGLAYGQAQPGVAWAETVNRLISAADKNLYISKRNGRNQTSPGNARSEMTSDVA
>D8FX82|diguanylate cyclase|EC 2.7.7.65|Kamptonema sp. PCC 6506|TrEMBL
MTSNRDRLTGLGNQELIQTRFEQYAGNRARFGMILIDIDGFIYFNDCYGHLEGDEKLRQI
TNLINQNLPDDIDVFRAGGDEFVIFIADSKMAEVVSIAMQLCEAVNQNFSHLPPLRRFFI
MPDFSYVEVHCPLTVSCGVAFYPEDGVNYATLYQAAEEAAIRGGKRLYGGVVGVAMNLYN
SCFLPSTDCKTTG
>D7Y0C4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain MS 115-1)|TrEMBL
MKMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFINCID
>W6K9Z2|diguanylate cyclase|EC 2.7.7.65|Magnetospira sp. (strain QH-2)|TrEMBL
MAPRSNGPTDPDVTRFDPTDGSLLTLLEISPAPVAVIVGIEQEVVFLNNKFIETFGYGRE
DLPDVNHWWPLAYPDPDYRETVRGEWRHRVERALAEGKTIEPMEAVVRCKDGKRRIVAFN
AASSGDLTFILFNDLTDRRGMGSYLQNMQARLEKAQALAGIGSWDWEPESNRLRFSIQAQ
AILGVPSETIGEGFQALLRITGPDCQDEVAGAIENCLAGFGPMTLEHEIHQADGTRLIVR
HLAERAASDKEGTVRLEGVIQDITDARRIQSEIRDSEERFRTLVETTWAVPWRIDVKSGH
FTYVGTQIEDLFGYPKESWIDIPAWSARIHPDDRTSALYHCISEAHRRREHETEYRLMHQ
NGKAIWVREVTAVVDTHHGTTEMVGYFLDITDSKNTEAELRKERDFTDAVLATIGSLVVV
LDRAGTIVQFNDACAKLTRYKAAEALGQKVWNLVLPPEKLAEVEEVFRNLKAGQFPNRHV
NPWLDRDGQEHLIDWSNTALLDDDGEVEFVIATGIDITNQHQMQKERDQLIEMSQDFVCS
VTQEGEFRLINSAFEKTLGFDRQSMMARPIWDFIDPRDRERTRDAFEVLKKGIPVNNFEI
RLLTKNGGTRWTSWCGTPDPETGLSFNIGRDITETRAAQAALNQAARVFEHTREGILVTG
ADRRIQRVNKAFESITGYSEWEVIGKRPQDFISSGHHDNDFYEKMWREIEDTGNWTGEVW
NRRCNGEVFPAWQNITAVTDTEGTTIQYIGIFSDITEKKDNENRIQRLAHYDVLTDLPNR
LLYTDRLAHALDRARRTNGLLALLFIDLDRFKNVNDSLGHQMGDLMLQTLAARLSNCLRD
SDTVARLGGDEFTVIIEDVDTPEEVGITANKILAALRRPVDLRGQEAVVGASIGISLYPR
DGTTAEELVKHADTAMYQAKDKGRDRTVFYTPDLTQGTEDRFRLEGQLRNAVENGEMEVY
YQPQVNMESGRLVGAEALVRWHHPTDGLVLPTRFIPLAEETGLIHSLGRWVLRTACFQGK
EWADKGLPVRIAVNVSNRQIMQGDMVRTVTQALADSGLPASMLELEVTESFVMENPEMGV
HTLNLLHDLGVWLAIDDFGTGYSSFSYLKRLPVERLKIDRSFIMDIPDDKEDEAISAAII
AMAHELGMGVTAEGVETVEQMDFLRPHGCEESQGFLVSRPVPAPEFEVLARDLHPADLPP
R
>A0A6S7EJD2|diguanylate cyclase|EC 2.7.7.65|Achromobacter piechaudii|TrEMBL
MSSSKSALPVWKSGADQACYLSASNAQAWVAVYQSVDAYTRGQVAAVVADSAKELVDAFY
STLLADVEAGPRLSHEIVATRLHKGMKHWLLGLLCVRDQGDIEALMATQKKVGEVHARVH
IPIHLVMAGARVLKNEIAERLRASDLDGMAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQSVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVTQLDDVVLPRLMMNEGDRQMSMPDQVRQLQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVIGREIAISSRQHSRFSVLLLDIDHFKAINDE
HGHSGGDHILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTGQEAALAAAQKLGAEIRR
HDFTIPEVGARRITASIGVATFDGHPDYAYLIDRADKALYQAKLAGRDRCVAA
>A0A6B8NBI9|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191c|TrEMBL
MNSTFSAAVARNPDLMHAVFESLPEPTFLINKSGIYVEAWGGTDTKRHHNPASLIGLNQY
QVLPADKAVWFSQVIVDVIDNQKPAELSYSLDPKDLTCFEGIQGPAEIQYFSALVIPLPN
TEYVLWTVRNISEYQRALNKLAEQQNELERLTLIEHLTQVYNRYAMDALLPDSIELARLK
GMGAAVFMIDIDCFKEFNDHYGHIKGDEALKAVGSAIKQWAHNNDLCFRYGGDEFLVFVP
GISEHMCIQHAQDLLDAIAQLALEHRTSHVSQYLTITVGIRHCDPIPADMTAEKFVGIAD
KALFFAKKHQRGTIHKM
>A0A212L893|diguanylate cyclase|EC 2.7.7.65|uncultured Pleomorphomonas sp|TrEMBL
MFALLILQLIAFSLFPLYFTTLSGPLRQIHFYIYISLVLLIGGFMGNVYSLPVADGVVIS
GGNLCYGAFMMTSVMFVWVEKDAFILRHLVRLVIIVDIFNIVFSFLTQSILRTDGVINPH
GVPPGMFETSTFLIALGGVLIIAELLLLLFIFEFIRKRKQALPVTAAIYILSFVLVLVLD
GIAFPFIAFGINAEIAAIVFGGLTGKVLIAIAFGMPLALFVLWKRQAFVDYLEADTIRWR
LLASSSADLIREMARKDQDVQRGDIVFKNSTDGLAVVAHTGAVLKANPAFERMLDIGDGG
AGSYPAHLQEAFWSDGRPVPLPDGPKETWRREVMFGQGRNRPGILSITPAGEGAGGGETY
VYSLTDITEQKNAQERLEYLASHDQLTGLANRRVLDRCLAELRDDAFALIIIDLDHFKDV
NDSYGHGAGDRVLQVVAGRLEAIREQYLKPGDTLCRTGGDEFALLVRSGDSGFIEGILEK
IQTALGQTVCIDDNLEVFSSATLGVSYKPRAGDRDAFLEADAALYEAKRNRRGSVGVYED
RLTAESQKKMKLGVKLKNALANNLLEVHYQPQFDAVSHKLRGVEALARWTDPELGVVPPS
DFIPVAEGTSLIEALGEYVLERACRDGREWLGSGYAPITVSVNISASQLRFGGFISVLSK
TLAKTGFPAGNLQIEITESSYIERENEVTPLLKELKELGVSIAIDDFGTGYSSFSYLREM
PWDCIKIDRSFITDIPRDTQQCGLVSTIITLAKVMSFKVVAEGVETRGQLDFLTAWGCDL
IQGYYFAKALPKENLLAMLPRDSESVALQPGP
>A0A2P9FCD0|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. MA5143a|TrEMBL
METESEPYVRLTTLRQLHQVMADMNTARSLADTLQTVADGVVNGLGYELACVNLVRPDGD
LVVAALSGNSAAEALITGRVGSRASWDRRLNMGEAWGDLRFIPHTEGWVLDEDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYTPGAGGASCGELLGVISVDRPRNGRRPGAWGREALQMY
AFQAAIAISNARLRANMQRALVRLEREQQALRASEESFRQAFEYAPSGMAIAELGGDEHG
RILRTNDALCRLLGRPASAMRRYAFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYVW
VSLRNSVVADAADGPRFLLTHVEDIEERKRRELQLAHRASHDALTGLPNSAELRSRLSAR
ICQRPQALPAGAAADSMDATFGENFGDGPTDGFGQYGDFGIAQHPSAQHPSAQHPAVPPP
HPSFDAYEAGGNGAHAFDFHAATGPYDAFDHHVHTVAPESERDDGTKGLAVLFCDLDGFK
SINDRFGHNAGDAVLIEVARRLSRGVRDGDTVARLGGDEFVVLADGLGRADAQDLAVRLR
NEIIQPIRVDGRAMRVGASFGIGWAHCGMTADEVLKSADERMYVEKRSRPKQHRRAG
>A0A4U9INY3|diguanylate cyclase|EC 2.7.7.65|Leclercia adecarboxylata|TrEMBL
MNNFFLQIIRMSEKALKQQIQNLKKHNARLARLARDARSKLSAALDGTGLCLWQLDVPTG
KLIIYNRRWGSMLGYQPKELNAQFEIWREHLHPDDKQNVLDAFYDHLHGKTPFYEALHRM
QHKNGTVTWVLDRGRVTEWDEQGNPLKVTGTHIDMTKEKQYEEQLAQLANHDPLTGLANR
HALLTHFAQLKAQGPLCIAFIDLDDFKTVNDTFGHRSGDELLIQLSQRLRDACPPGAVVG
RLGGTSLCCCCPSRSPACW
>A0A385Y3L4|diguanylate cyclase|EC 2.7.7.65|Dickeya dianthicola|TrEMBL
MRIKKLLQINLLHLILFISLASMFVTLLNSYFTFYHVQKKLLIEQANKVNSSYSSKLSTT
VDNFFSISEEQLSYSARLIASHIQSGNIRSLQVELQRIHQLSHAFNSMVVVTGNGQIIAA
SPISLNLTGITLTSNQHLTTLREKRFFISSPYTSLSGNYIIFISQPILDDAGNYLGYIGG
SLYLNSRRILNEFMNTQFSNDSFNTYVIDKEGTIIYHHDTSQIGRKLNDSHILNSITNQN
KGSFMMPDEQGIPSPASFIRTQKADWIIITQQSFHSIEEALNDVMLSVLRQGTPLGIVAL
LALSILAYYISKPLRQLAKSASSMEQLGVIGKIRSVKAWYLEVEQLKRVLLMGTVLLHKR
IGRLSSEAHTDPLSGMLNRRGMQESMEEIRNEYKKVSVIAIDIDHFKVINDSFGHDVGDE
VIRKLSQQIRKNFRKNDLVCRIGGEEFLILLPGADIHVATVIAERLRNNVANTVYMPGSR
HHQVTISIGVTTFNPQKSALDIAIKTADNALYKAKNGGRNQVVVEYLSDDISLAQH
>A0A8F9TXX5|diguanylate cyclase|EC 2.7.7.65|Oleiharenicola sp. KSB-15|TrEMBL
MTEARKVLLIDDDRLQWRIVEQQLRAVDRAGFVLTCAGTYEEGLKKLTSNGFAACLLDYQ
LGERDGLQLLREAVAAECRTPIIFLTAESSSAVDIEAMNAGALDYLEKRELTPRALGRAL
RYALKVGETMEALRRLATRDELTGLLNRREFTRVVREEEERARRFDRSFGLVLIDIDHFK
AVNDTHGHAAGDAVLREVARRIRERVRAVDRCARIGGEELAVLLPETDVAGTLAAAEDLL
AAVAAAPFEVTGGIRIELTVSAGAASLPVHASETGPLMEAADRALYRAKRAGRARAMLAE
HA
>A0A1C3JTV4|diguanylate cyclase|EC 2.7.7.65|Marinomonas gallaica|TrEMBL
MVLFMDLNKFKSLNDTYGHYEGDQYLAKVANVLSDRLSDQGLICRIGGDEFIGVRSVECC
EACDKHILITNIKQDIQDISVIYPDLKLGISIGVACFPLDGQSTQRLIEVADERMYIDKH
KSRH
>A0A1V5GKV2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MNIQSIILSNSIGCIILIVLMISSHLVRQRRLLSDRLFTLMAALTASGCILEMVSFIVDG
KTFNGSHEIAMSLNTLLYLDNISASFLWCLYVDLRFYSSRQHTADIAAKLCIPYFIGVAG
LLANLKGEFLFSIGSDGFYQRQIAGYAYYIIMGFYLTVSVLMRLRYKNATGRPKFFPIWM
FILPIIIGTTAQMIFYGISLAWCSVAIGLVGIHMSLQNELAYIDPLTKLYNRNYLNHIMN
QMMYSHSSMCGIMLDMDHFKYINDTFGHTEGDNALVETARLLISAVSEKVIVIRFAGDEF
ILLFPGGSRNELDSAVKSLRTAVNEFNNSNKKPYAISFSIGTSIFDGNSDADSFLNEMDE
NMYEEKKIKHQKAAAV
>A0A1V5GQ34|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.BinA205|TrEMBL
MPKDKASDGSDNLKRMKQLKFFLIAGFAVIAFCSIIIVSLLAIHRTDTVLKNKVADLTSS
LNVQMKLNLESFMSRMETIGNLAFAVEESYTYDATDPSNDEYDALVTEKAISDKLYSLCI
MENFVDYGIVYRNNHFIGKISNGTISLFGDRMYEDLHSMINRQRTNDGWAAGYGQNFKRI
YYVKEIHENAVLIISFYASELEKVFDNPENLADMVIRLTDNDYGLIYSSDKMEVPGEKLP
EEIKERVEGKKAVTILDNEYLVTVSTGEDNWYIICSIPTRIILKEKNVMRTHIMLTAIIA
SALAIILGMVLSIKLTDVITNMVHNLDTKANTDQLTGLLNKKTFEDNAEKILRDSDEKDN
HAIILLDVDNFKGVNDTLGHAYGDQVLARIGRTLTEVFSNKDLIGRIGGDEFCVMMNIDQ
RPYEEYKALIEEKCTILQDEFHRYYTGENMDYKISCSIGIAMFSLDGRNFSELYSAADEA
LYLSKHRGKDIFTFFSDKEEADTE
>A0A564WHR0|diguanylate cyclase|EC 2.7.7.65|Candidatus Defluviicoccus seviourii|TrEMBL
MRMPWPHGLPSLTTNGFGAADGQTVRPPRHTARLLRHGLLAALLLFGATAAFQLSTILQD
RADGMSRYVRVDAWAVGQLEYELQQFRSRLARHVAGDAQAPWALVAAQLNTVRATLPLLH
RSQEYEQFRLFVDVDGTAAAVGAALDRVNGLLTDRTGLAGDLATLSQVEAALAAPLIRLR
QLMVDVATVRSDLQDGDLANVRWLIGANRWMLLAFGGITAVFILLLMKEALDARRAERIA
SDSERKSRHIAEHDGLTGLPNRMLFHAHLREAIAGAAASGHDVLLLTLDLDGFRDINDTF
GHDFGDSALTAAADRLRQALPADAFLVRLGGDEFAVIRTGSGASESEDALANHLLATFQQ
PLVCGDRTVQLGTSIGAARFPVDGTDAETVMRAADLALHAAKAAGRACFQPFRIGMMTEV
ERRQDMQEDLRRAIADGELEVFLQPQIDLASGGCIGAEALLRWRNGDKGWISPGVFIPLA
EQTGLILPLGRFVMEAACREAMRWEGAAARATIAVNVSPAQFLYQDIYAEVCEVLEATGL
PSHRLELEITEGLLMRDQRAAMAVLKRLEDLGVQLAVDDFGTGYSSLSYLKQFPVQKLKV
DQSFVREIEANASDKMIVRTIVTLASGLGLRTIAEGIETPAQSRILGELGCEEGQGYLFA
RPMPAADFRSWTSTWLAQAGAQPAILALAAG
>A0A655UAB6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MGLTSHKYKYVSIYFLALLFLGIAVIESLHISHTRDLQEGLRQQAKEDLSIVRFQLEAEI
LGDIYTVKGLTTLLTLDPDLNIYXXXXXXXXXXXXXXXXVIRNSDHLRSLGIAPNDVVAF
SYPLPQTNALLGLDYRTVPQQWQSIKKAREIKQTFVSGPVDLVQGGRALVIREPIFYDPP
KDTRYWGVLSVVMDWDSLLSATSIYSFGEHFQVAIRGLDSRGSEGDVFFGEPRVFEHAFA
QENVYFPYGSWRIAVAEKQDLLQQLSWYTRNAVRLLGYSVLLVLMAGFGVIMRLYQVAEE
RALHDPLTHLPNRRYFIYTIEHYFENAKRSHSEGNFALLNIDIDRFKSINDSHGHSAGDK
VLVACAERIKSSLRVSDLVARIGGDEFLVLIPRIHREQDVLKVSDNILKRISETPIVYDD
KLIHVRVSIGYALYDQSFATPDEMFKLADERMYTAKRRQNPLYRF
>A0A8E6RU64|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Shamba|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8G0CER0|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNISSLHTAIYHSLMEQIAVIDAQGQIVDVNRAWVEFGQNNGVDEQYDWIKVNYLDALYK
ASQEGDTLAFEAYQGIKAVIQGQSDSYYHEYPCHSPNEQRWFLMRVVPLKIEQYQYWVLS
HHNITQRKLAEMRSEYQATHDPLTGLANRRHFHQQLEALLLENQQQQAGLCLMMIDLDNF
KHFNDTHGHQAGDLCLVRIAATLQQHLSVPYTAYRLGGDEFALLLSHLTQQQSQDIAASV
SQRIQELRLLCGNKLQVTASIGGIFISGETQISSHLLINETDQALYQVKRGTKNSYLLTT
LSSAPHTVAAEALGNELID
>A0A1H2F966|diguanylate cyclase|EC 2.7.7.65|Pseudomonas guangdongensis|TrEMBL
MPRHSPERLASEWAQLLAAFPPEVRQLVGDQARARCELLASHFYEQMLQDSQASHFLSHD
QVQSRLHASMQRWIVSLFAAGLDEELPAVIALQTQVGEVHARIDVPVHLVLRGARHLKAR
FAALLQELLPAEDARLFPAVRLIADVIDLAMEIMSQAYASSHERNSRAEEAYRLFAVAQN
IGSEKERQRAALLDWENQLMFDLAVGLEASQLPRIGSTEFGLWFRHKGSHAFEGTPEAEL
ILQAMQHIDEVLLPMFGLPGGVEPRERMQRLRDLREQAKSIGYHLERLFEQVNELEAGRD
VLTRLLNRKFLPVVLGKEIAYARQRGNRFAVLAVDVDHFKQINDRFGHDAGDQVLQQLAT
LLSNHSRGGDYVFRLGGEEFLMLLVDVSADSALKAAETLRKKIAADLFRLPHEQSLQVTV
SIGLALHNGHPDYQRLLRRADEALYRAKHGGRNRVVVAAEE
>A0A655VX58|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MVNRADSARLLSDQDLQGYVSRILDVIPLPIIISKSSVLGQGEREHLHFNKAFVKELGYT
MAQIPNIETWFERAYPQIDYRQEIIAQWQKTVDEARAQGEDVAQMPALIMCADGVQRWFS
VSAQIEPSCRDDLHIITFRNIHDYKISLAEAERQSQIDPLTQLKNRRGFFTWSEPIAPET
LLGLIIFDIDHFKQINDTYGHPAGDYVLRQIAGLLEQNLPPLSCCVRWGGEEFLVCFECD
DMANVIGLAENIRGYVESHTLMWQGQQIALTLSAGCTMGAMMSHNWDNLLHTADQALLSA
KRLGRNRVIAAR
>A0A655Z4X5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MNTHCRELDLLFRLGGDEFLLLFENTSLTDATLVMSHIGCRIQQTHYPYHAKVTVSVGFX
XXXXXXXXXXXEQWFKRADQALYHSKKMGKNRVSFDEEHVIELNGDHCHALLGSTHGHR
>A0A655WBF4|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MIDLDHFKQVNDNHGHPAGDLVLQRVVALCQRHIAQVGTLCRWGGEEFVVLLPHMTQQEA
YQRMESIRAEIAMHASQPQVTVSIGVVQYQQNESLLHLFNRADQAMYTAKSEGRNKVVGL
>A0A655PKJ6|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae|TrEMBL
MTGIRLLACCGVQICSVFLLIISSSAYAVVEHISDYFVETWTSTDGLPHNSINSIAQTRD
GYLWFATWEGVVRYNGINFQVFDRNPQTGMVDSGTRTLLPMDNNGLLVAGARGSITHRQS
YGWQSFRSAPSLVNGALIDDAQNLWLAIEGLGVVVRPYLGNNLYGPDRWLLTDASVYRLV
KNQHGVIFAATDKGLYRFNDWQASAMELPIGRYERINYISISLNQELVVATDQGVWINTE
EGFQSLFVPLEKEVVTLAEQDRAGNWWIGTVNRGIARLKNQQLQFLEPSRGLPYSRVLSW
YQDIEGSVWVGTNAGIMRLRDAPFININSDKGLVGDYVRTLLPLDDRRVMVGTSRGLSII
EEGLAHSALMPQVGARPSILSLAKADQQGEKVWVGTVQKGLLLWQNGQLRPVLDENNGLP
SSEVRAIVTDPQDNLWIGTSNGIVKRTPQGVLTAYNKDNSPLPDDYIMALAVDSEGKLWV
GSAVGVAYFDAQGKIRPVDLTKQEQAQYVFGFYMESDYVWMATDRGIVRYRLSDASVSLV
GRAAGLPIDKFFQMLRDSEGHVWLSSNRGVWKLNYDQMLAVADGMSTQLEFEHFDEGDGM
ATSQANGGTNPASASLPNGELLFATAKGVASIKVQRLQQLSELRLPVVLESVSFDSEIIN
PDQQYIAAAGTNRVSFGYVGLGFVMSERLQYRTKLEGFDRDWSYRGHNTQAEYTNLAPGK
YRFFVSARYPYGEWNDATFSYVFIIEPHWWQRKEVIVMAGMLFLALAVSLVMWRIRILKR
RELYLVEQVALQTQKLRLQAEKFERLSKEDDLTGLANRRAFDMYLKQAFSRLQNPDQQVS
IALLDIDHFKQINDRYSHIIGDQAIVAVSQELLGYVGDKTRVARWGGEEFTILYVGDPKQ
AWGYFEKLRCKIEQVDLSAVAPGLNVTVSIGFADAQQAESYETVLKLADHALLTAKKLGR
NRVVKSEEWQVKSGLH
>A0A7I0KQ92|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O25b:H4|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFISLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQVGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A352E587|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp|TrEMBL
MQHIPNEQLAGEWRRLLGQFSPEAAAVLHGVAEQSNEDLAAHFYEQMLADPHAAVFLSHE
QVQNRLSLSMQRWVLTVLTSRPEDDLEAVIDLQRTIGDVHARIEIPVSLVLRGARYLKGR
LRRLVERQAAEAVTRRDAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFAVSQNQ
GAEKERQRAALLDWENQLMFDLAVGSGYESLPRLASSEFGLWFRHKASHAFQGTPESASI
LDYIMQIDQELQTLAEAGKEQGSLSSLHRVREQTRSIRFLLDSLFEQANELEAGRDVLTR
LLNRKFLPVVMTKEMLYSRQAGGSFGVLIVDVDHFKRINDAHGHDGGDQVLQQVATALSN
NTRGGDYAFRLGGEEFLLVLVDIDAQKITQAAEKLRQRIAEDSFRLPQGEVIKVTVSIGI
AVHDGHPDYERLLRRADQALYEAKNAGRNRCVLARNG
>A0A8B3KAV1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNVFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRMLLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERTAMSLDEQWRMIKENQLMMMAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQKFRRSFSDPALSHALDRRVFHEFFQLAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A7Z8BDF3|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSI
AAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTI
VEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNN
WSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDI
NKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVS
LSIDILYFITSSWKSVLFWILTALILLNMVRMHFRLYQNVSRENISDAMTGLYNRKILTP
ELEQRLQKLVQSGSSVMFIAIDMDKLKQINDTLGHQEGDLAITLLAQAIKQSIRKSDYAI
RLGGDEFCIILVDSTPQIAAQLPERIEKRLQHIAPQKEIGFSSGIYAMKENDTLHDAYKA
SDERLYVNKQNKNSRS
>A0A7Z1CYK1|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A378IV76|diguanylate cyclase|EC 2.7.7.65|Legionella feeleii|TrEMBL
MKNFNQRVLLNLFLLILFFLQIGVNVSSYVQIQHLLNAKQWVLHTQELISAINDLWGNIL
EISVYTRGYVITGDANSVQALNHASTAASIKVQNLKLLVKDNPKQLERLNHLTTLLKERI
HFSNSVIAIYQKKGEEAAEDLLIKNRGTLLHQLQRVIVSMINTEKSLLNARDDELQKTSD
TTLSYIKMTNTLTFVLFFLFLGIFNIQFSRTLKLIQRRKQAEDQLKGIISGTNDSIAAID
KNYNLIAFNPSYAQDFLQLFGKSISLGDNLNDLLQHLPSEQTNQINLWEKALSNKKFSII
EEFGDSKLTRNSYEITYSPIHNADNILIGASQIARNVTARLKIEKEMERANAQLTKNIEE
TKQRNHAVYLLNQLSSTLQMCLTVEEALEPIAIYGQKLLPNTAGSLYLAHPSKNYMDCVT
GWGKPAVEEKIIGTEQCWSIRRGQIYHYYNSEQSIPCQHVKAVKPIPCYVCIPLQAQNEN
IGLLYLEFLNSQHLGEKEFQQLLETRYEQLIISIAESIALSLSNIKLHASIKMRSIRDPL
TNLYNRSYLEEFFARELQRAKRQNSKLASVIMDLDHFKKVNDTYGHEAGDVVLIEVANLL
TRNIRETDIVCRYGGEEILILLIEVNSAEEVYERIDQLRQEISKLEISFQGKLLEKITAS
FGIAMMPEHAETQSELIELADRALYQAKKQGRNKVISYKK
>A0A7Z8BJU8|diguanylate cyclase|EC 2.7.7.65|Shigella sonnei|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPNE
IYRLADNALYEAKETGRNKVVVKEAEILINRKDDE
>D2AAR8|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri serotype X (strain 2002017)|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLVMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VILGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAADVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A3C0X9I3|diguanylate cyclase|EC 2.7.7.65|Stenotrophomonas sp|TrEMBL
MDTPHLDDASQPLAEAWQHSLQQAGPAATELLHRVARDAPPLLAQRFYEVLLDDARARRF
LSHEQVKDRLQPAMQRWLVQLLTTDIGAVASGVAAQRVIGDVHARVGIPVDLVTRGARVL
KHDLFARLQAQASDSATAFAAITCLSTVMDIAMEGMTLAYTHARERSSRTDAAYRLFSLV
QNVSTERERQRALLLDWENTLLYTLAGHASSSDSASLATSEFGLWFTHKGIPSFGESSET
QQVGQLIARIDSGLQHAIADNPAQRLAQLPAIREDLASIRTLMTLLFERIGELDAGSDTL
TNLLNRRFLPTVLRREIELATRHQTPFSLLLLDLDHFKAINDGHGHDAGDRALQHVATLL
SQSTRGSDYLFRYGGEEFVVVLVAASQSQAAVIAEGLRRQIAQSPVALADGTVLSLSASI
GVAGHDGHPDYERLMARADAAMYAAKEAGRNTYQYYSQDALARIQRRLEIEHGLHGAIER
EEFSLAYQPLLHAHNGEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLNE
ACRQAAAWDRAGLCFERVAVNVSAVQLRDRGFAERVIEICHAHGWPPQRLELELTESALI
RDTDILRHCFDVLERHGVPLAVDDFGTGFSNLNYLNRFPVGRLKIDRSFVQGMLHDSGTA
EVTQAIVHLGHALGMKVVAEGVETHQEEDMLRRQGCDEIQGYLYSRPLSPRDLAQWLRQQ
HAGSEVALAR
>S1PZS4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE182|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSQRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAVYVSRA
GFYVSTLPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTSMLLLSWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKACPLA
KLCHTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDIAGRVGGEE
FCVILPGANLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A0M2WJT7|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. KBS0711|TrEMBL
MWTKPVLRMNLRRLIVLVAFASALVSLANTFYASYSVQRQLLIDTTLEANHAYASKLAST
AEDFLQSARQQLAYSAGSLASRMGDDAWLTDEAQRLRLQTNSFNSVLIVNADGKVLGVSP
ETLALKNRTLDSAGAIQALRERRPLVTQPYVSSAGNLVIFISHPILGKDGRYLGYVGGSI
YLKQKNILYTMLGQHYYRDGSYLYVVDQNRRLLYHPDPERLGDLAGKNDVIDNIIAQQGG
GNRRMHNSLGVDMLAGYAVMPSTGWGIVAQRPTAMTLAPLNQLMADTVWHSLPIALLSLP
FIWWLASLISRPLMQLADGARRMDAPGTTEHIAAIRAWYVEAAQIKKALLKGLMLLQNKI
GKLKTDVQTDPLTGLSNRRGMAAALDVWQAQARPFSVIAIDIDHFKQVNDQWGHAVGDDV
ILRLAQLMRACSRDADVLCRNGGDEFIMLLPDADLDAALQVAERLRARVAAAVIPGAGPI
TVSLGVVSSEQEAGATDAVLLAADAALYVAKENGRNCVGITEPA
>A0A7H0MC69|diguanylate cyclase|EC 2.7.7.65|Kosakonia sp. SMBL-WEM22|TrEMBL
METYLKSMKGEWLTLLEKTDQHIRRLTAEVAHSHAHELSETFYRIVLTDPHAREFLSNAQ
VEIHLKSALERWIREVLACKPDDIERLIQQQHTVAEVHARIGISVELVEMGFRVLKKLFY
PVIIESHFTAEEKLQVYHHAINSIDLAMEVMSRAFSFSEHNSAKEDENYRIFTLMENAEE
EKERQTAALLSWEIDLIYKIIMDADLGNTLAISQSDFGLWFNHKGRHYFSGIAEVGHISR
LLQELDEIFRSTRATPRSLSNRALRVGFLISVRKNVVQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFMPTIFKREIAHSQRASTPLSVLIIDVDKFKQINDSWGHPMGDEILRKVSNAF
YDNVRSSDYVFRYGGDEFVILLTEATEFDTHRIGERIRSRVEKTIIKTAEGERVPISLSI
GAAMFDGHPDYERFIQRADEALYIAKARGRNCIHIWQAAE
>A0A5P9IWP8|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. THAF3|TrEMBL
MARSVDEWSPQELNKLQKKNKRLKALLQKYKQQHHLQHALILLSEQASTIPELCSFYPAI
QRLLADYVPSKNFYVVLRNPDTGLLELSYFVDQKDGIQTPLVTDQHFEQGVTGYVFRSRA
TAYFTRETMTAAQQQGKFKILGAQAEHWLGVPIYQDTDVIGVMVSQSYDAKQGYSQEQIE
LFEVIALYLATAIERVKKRELLESQVKQRTQALTLSNQALNDEISQRKKALERQQTLFQI
SELASQSINIDDVYYHVHQIMKSITYAENLYIALYDKDNNWLTFPYAVDECSEDFGPRPF
AKGFSELVLTSKQCQLIDRARSEQLIAEGIIERQGKLDPSCRCTSWLGAPLKTAQGVIGL
IVCQAYNNKYDFVQEDVELIAYVSNQIANVLQNHLSQQALRQSHQELELRVAEKTRELRQ
ANLHLQLQIDERRKIEQQLYHDAHHDSLTGLPNRSLFLSQLERTLGQYQRFPEKDFAVLF
IDLDKFKDINDKLGHQCGDQFLIEVADKLKQCIRDHDLIARLGGDEFVILLTQLNERQQA
EDVAKRIIAVMQQPFCNQGICIQSGASIGITYSKRDYSHTDEIIRDADAAMYYAKQTGKG
RFEFYHPLLGYGNDQQEPHQRHHLMDLHTHFRASDIVNFDQQQPHAQLLDAYGEHPVLGS
TSFEQLKRFASDNYELAKVELKLLKYGFNQHQSDIMSLLNCSSLLLDDKHFEGLSHWVGQ
LTNKDKLCLLFSEAELRFCSANQMKNLDKLYQQGLHIGLNEFGKDRCELSLLTQLPYFCV
LLNATFSRRVLQDPRYDHMLQGVLAVTQLNDCMVIAKGPCILNYRSLLEHHGVHHFIGQQ
HAIAEQQPLHAIPS
>A0A449IK13|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fragi|TrEMBL
MSGLNAPQRRRRLRSVLRRGHLGVALVAVTLASASMTLLGVLALKVYADHNLHLIARSIN
YTVEAAVVFDDPGAATEALALIASTEAVAEAQVYTAEGELLAQWQRPQTDLLSRVEMLLA
DGLLQQPISMPILHQGQEVGRVVLRGHGANMLRFLLSGLLGVLVCTALSAWSALYLSRRL
LDGITGPLQQLAQVAHAARRERAFDRRVPPAHIAELDSLGNDFNALLDELESWQSHLQNE
NEALAHQASHDSLTNLPNRAYFEARLTRTLRSLNKTRDKAAVLFLDSDRFKGINDAYGHA
AGDAVLVAVATRIRAQLREDDVVARLGGDEFAILLTPLHKIEDAQRIAEKIIASMLEAIA
LPGQVSVVTSLSIGIAVYPEHGASAQELLCAADSAMYQAKRLARGGQHVAESEHPANTVN
IRS
>A0A5W7RXR6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Kintambo|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKSGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A5E4S9P2|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MTLALCTPADAGRVHRFPGDVRLAAQALWQTSHVPGAARPAAPQLPSEGWRGRIDGVSEA
TDRVSTLRDPLNFQSHPDEAARLAALRRYEILDTPPEPAFDRIVRLASYVLGAPISLVSL
IDESRQWFKARQGMEAEQTPRSMAFCAHAILDDEVLVVPDARADRRFADNPLVVGEPNIR
FYAGAPLRTPEGHRLGTLCVIDRKPRTLDDEKRALLADLSALVVDELELRRVNHVLGDMA
MRDALTGALNRRAFLLQAERQFAAARAQQRRLAVLMLDLDHFKAINDTWGHAVGDLVIVE
LTVVLRATLRKDTVIGRLGGEEFAVLLPDADAERAMQAAERLLAAVGGASVPGPNAPIRF
SASIGVGGLAPDDADFGAVLQRADRALYAAKQAGRNRVAAL
>A0A5E4UAW1|diguanylate cyclase|EC 2.7.7.65|Pandoraea morbifera|TrEMBL
MKSTISRTEQGNRVAATTILVACAALTLAGFLTRALEGTVNPLLTFFLVSAGGILNLSTA
CLLGVQYLYNGKRYFAQFGCAFLLRGLFMFTEGVLLANQLAGIATHVTRAPFWLWWMAEA
SFAAYVMLSVRSYSRTRGDPHTRPGYTEAARYGATVLVIWMVVSFSLVGAGRMLVAPHLA
AGIDVETLALGALFVAYVALWWRVAAVTRLSHKLFLLVWVVVTISLCQLLLSLTAPSEAS
YQWYAARLLALASPGVATLALVWEITRQYQSLALTNTDLVEKVFIDPLTHIYNRRYFDNR
IRLVAERVQQRAIPLSVLLIDIDFFKQVNDRYGHPFGDAVLQRIATTIQHCIRLPSDFVV
RLGGEEFAVVLPEIDQHAALRVADRIRESVKRASTDLLPAKARDEGEAITISVGIATWQP
GEPLVISAMLEQADKALYQAKHKGRDQSVLGQRMAA
>A0A267CUM3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fragi|TrEMBL
MLKTIENEISKQAAPPALQAEFAQHDFEKLRNFCSLTYITSIAIWLLFNLIVSTKGGQGF
TGLSLLFISVMVGLTIILGFVGNYRHFDVLNTVFVAIITLGLRLIIFGLPAETQPIWLAL
ATSSILYSASVLPLSRWAFLAVAAISCVTLNPFLMADVSVMDLRGLLILCYFTFLCSLTT
YSFFKLRRIKLHNYTMSKLLVAQAYIDALTEIPNRRSFMLQAGHVLLTRPREHDHYLAMI
DIDNFKKVNDQYGHDIGDEVLKRTAASIKAVMADFAYARLGGEEFAVYLPGVRREDVEVL
AQSLCRRVREDPDAHPVTISIGLARVEEEDTLNQALAKADKALYGSKHDGKDRFTFYS
>A0A6I2ICP6|diguanylate cyclase|EC 2.7.7.65|Enterobacteriaceae bacterium RIT714|TrEMBL
MKKQYQHVLVTTPHPLLRLVSLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNILASWMLFSWETISFWYTAINVIEACVGALLLRKLLPWYNPLKN
LGDWIRLAIGSAVIPPLVGGILVWLLVPGTEPLRNFLVWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLLTMAVTLVLCWVAISFLPWPFTCVIVLLMWSAVRLPRMEAFMVFL
VTVMMVSLMMATNPTSLTTQNTGVMLNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCQFLGYSQTELQSLTFQQLTWPEDLNIDL
DNLEQLTRGDINSYSMEKRYYNRNGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKHT
EWVNKRLMERITLANEAGGIGIWEWDLKPDVISWDKRMFELYDIPAHIKPTWQLWHECLH
PEDRDQAEQIIRDSLMARAPFKLEFRIRVKEGVRHIRSLASRVLNKQGEVERLLGINMDM
TEVKELNEALFQEKERLHITLDSIGEAVLCTDVDMHVTFMNPVAEKMSGWTQQEAMGQPI
LNVLHITFSENGPLMENIHSGDMSRSDIDQDVVLHNRSGGTFDIHYSITPLSTLDGQNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKRLLQTVDDTHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRIIHAINDYHFMWEGRLHRVGASAGITLIDDRNSQAAEVMSQADIACYASKNNGRGVV
TVYEPQQERIHSARSMMSLDEQWHMIKDNHLLMTGRSVASPRIPESSNFWLISLRLWTSH
GDVMEEHAFRSGLAEPELLHALDRRIFQEFFRTFAAQVANKGMGVALPLSPEGLCSVTLV
DELLELLEKSPLPGRLLHLVIPVKTLQNQDVNIQTGLQKLRQAGCRIVLCHVGRDMEVFN
HLSAHMADYLLLDPELVTNVHGNLMDEMMVTIIQGHAQRLGMKTIAGPSNHPLMMDTLSG
IGIDFIYGDSIAEPQPLELLLNTSYFAIN
>A0A087DBW8|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium saguini DSM 23967|TrEMBL
MSKPIEASIVVVDDEPSIRELLVASLHFAGFEVNTAASGSEAIEVIEKVQPDLIVLDVML
PDIDGFTVTRRIRQEGIDAPVLFLTARDDTQDKIMGLTVGGDDYVTKPFSLEEVVARIRA
ILRRTREQVEDDPIIRVADLEINEDSHDVTRAGQPIDLSPTEYKLLRYLMDNEGRVLSKA
QILDHVWQYDWGGDAAIVESYISYLRKKVDGVEVTDENGEKHKVTPLIETKRGIGYMIRE
PKH
>A0A8G0JM04|diguanylate cyclase|EC 2.7.7.65|Lysobacter sp. CJ11|TrEMBL
MLIFLLCLPAMAAAQAQSVADIIAQTRMHGYDAPSTRIAALEAAKDRPGENASAEAKRQY
FVALGQLAAAADNATAFTQAIDGLEQAGQSQACKPCKAQAMVLRASWDLTRKGAATTLTL
LTRAEQAMGSDAPPDAWAHLYAARARNYRLAGHYAKSIQDALKALRIADQQKNAALQVEM
TILLALDNASLGDFPRADAYIKEAISQATRIGFGFQLAYGYLNLGHIYALRNNREGQYEA
LTNALQRASAVPDLAEVRMIALSNIADYHLQRNEFETALDYAVQAGTLARSLDEQRSLAI
ALTNEGIALSHLGQLDKGIERVQQAIAIATKMQNSEHVIGMTKELIGIYERSGRYKEAVD
ALHRVAEMEKTLTAQERQRDVLALQEEFAVERKQQEIDRLSAINAQQKALAEARNAQRWM
WLVVAVALAIAAFYLVRRLRGVRSANRRLSRANEVLEEQTARDPLTGTYNRRHFQNLLQQ
AAAGLPKHELRTPQPFLSLVVLDLDHFKQINDSFGHDAGDAVLIEVSRRMRDLVRTEDSV
VRWGGEEFVLVLPGTGADGACTVVSKVLAAIGSTPVRYKSGSIPVTVSAGATTIPETGVR
AWRFALQIADLALYRAKGGGRNHAVCVSLIDERALAETEEEIDLDQAQAQGHLRLRDVAG
PGVGTS
>A0A1V4J0Y5|diguanylate cyclase|EC 2.7.7.65|Clostridium chromiireducens|TrEMBL
MNKLYFLKKPNLNLTKDQIANVVHDINVTNFARMKLILIIFIIVEILFILFNDIPYLITP
SSNVIWNDSKYFILHSFNVLVSFIGIILIKISTKCSKNKFGLMNKLLIPTLATLILSSMA
IINGLDQAKPGNVSSVFIANFIIFSAVIMLRFPLNLAVYSISFLAYLGGLVIFQHDTHLL
ITNIINGFIFFLAIILISTEIYNSNYEKITQNIILQEINTKLNYMSSHDPLTELLNRRSF
SNQVSEKMILIDESKEISTLILIDIDHFKHVNDKFGHPVGDIVLKKVSNIIIKHIKTTGL
ATRWGGEEFLIFLFQTSINEAHALAENIRLEIQNKVIEADKFQIQITASFGISLLKDNFS
NSFDTSIKAADVALYKAKDQGRNQVVIASEDYERVLY
>A0A7W5N5K7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. Tn43|TrEMBL
MNDLQLDDFKTDENAAMVLLVDDQAMIGEAVRRGLSNEENIDFHFCADPHQAIAQAIRIK
PTVILQDLVMPGLDGLSLVREYRNHPATRDIPIIVLSTKEDPLIKSAAFAAGANDYLVKL
PDNIELVARIRYHSRSYMTLLQRDAAYRALRVSQQQLLDTNLVLQRLMNSDGLTGLSNRR
HFDEYLELEWRRSLRDQTQLSLLMIDVDYFKSYNDSFGHLEGDEALRKVATAIRDASSRP
SDLPARYGGEEFVLVLPNTSPGGARMVAEKLRQTVAGLKIPHIFPTEGSSLTISIGLSTM
IPQPGSDCRQLISAADKGLYLAKNNGRNQVGIE
>A0A381C5B7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella agrestis|TrEMBL
MIKQNTKELIAMPSFVLPVGLGFLSFIFTLYSLELSLVGTVLAPLWFPTSLMMVALFRNS
FRQWPMVIAVCAVGSLCASAVLFPLNEINLGYTAINIIEAVLGATLMRRLLPQHNPLQNL
HNWVRLVICSAVIPPIVGGILAVWLAGPDGGSVAKTFFVWMLSETIGSLALVPTALLFKP
STLLRHKNPKLLLETLFTFVITLTLSYLALRYMPWPFTFIIVFLMWSAIRLPRLEAFIVF
LGTLMVVSLMMATNSHIDMQQPHTTVMNNAPWLPFLMILLPANVMTMVMYSFREERKHIT
ESEARFRNAMEYSAIGMALVSTDGQWLQVNKSLSKFLGYTSDQLRSLTFQQITHPEDLHA
DLHQLNMLVSGSINSYSMEKRYYTSKGDVVWALLAVSIVRDIDGTPLYLIAQIEDINDLK
HTEWVNKRLMERITLANEAGGIGIWEWDLGTDVISWDKRMFDLYEVPAHLKPTYALWLER
IVADDAPAAEKTVRDALQARVPFKMEYRIHVKEGIRHIRSLANRVLNKNGDVERLLGINM
DMTEVKQLNEALYQEKERLHITLDSIGEAVICTDVDMNITFMNPIAEKLSGWPQQQAIGQ
HILAILHITFGDNGPVMENIHSGDYSRATIEHDVVLHCRNGGSYDIHYSITPLTTLDGQS
IGSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFENHLKRLLQSAGENRQRHALVF
IDLDRFKAVNDNAGHAAGDALLRELSSLMLSMLRTGDFLARLGGDEFGLLLPDCSADNAR
HISERIIQSINDYHFTWNGRLHRIGASAGITQIDADNRLASEVLSQADIACYASKNGGRG
RVTVFESSQHDIRKDGQNITLAEQKSIINDNPILMIALGVAPPRIPETTSFYLLSLRFWG
NDGVVIDEKTFRAAVTDAELHCALDLRIFNEFFSKFSQSVTNKGFGVALALSSHSLACDK
VVDELLVLFTRSTLPTRLLHLMVHCEVLQNDDEKIERNLQRLHDSGCQLILSHVGRDLDI
FKRVARQYFSYIIVDEELIQNVHCNLMDEMMVTIIQGHAQRQTLQTIAGPADIPMVMDTL
SGIGVDLIFGEAVTQPLPLEMLLNSSYFAIN
>A0A3R0LL40|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A658XYE3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIVSTLVSHPP
PGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTA
MLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPIIVVYP
LMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNRDATLL
IIDIDHFKSINDTWGHDVGDEAIVVLTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESA
ITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRN
RTEVAA
>A0A8H9DDG9|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTLLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFST
LRPQITELMMSADIVRVDLLHGDKQVYTLARNGSYRPVGSSDLFRELSVPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIIVMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPRTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAAQLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTHV
YATGVRSRSEWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A1S8DII2|diguanylate cyclase|EC 2.7.7.65|Halopseudomonas pachastrellae|TrEMBL
MPRLSVEQLSQEWSLLNQRFSAKSRRFVLSFCTRHAVDLTEQFYSEMLADPAAALFLSHD
QVQGRLSQSMRRWLEGLFDAEAEGGLARIIAEQKKVGEVHARIDIPVHLVLRGARCLKDR
FIELLHEDRELSDREHLDTARLMSDTVDLAMEIMSHAYSAAHDRNSRNEEAYRLFSVTQN
ISAEKETQRAALFDWENQLMFDQAVGQPGAHLPRILASEFGLWFRHKGAHAFEGSREAGQ
IIEAMEQIDDVILPLFDGDAEERIARLRELRETVKSIRFNLDNLFEQNNALEAGRDVLTR
LLNRKFLPVVLNRQVSHARTHGTPFSVLALDIDYFKRINDSCGHDAGDRVLQQLATVLVN
SSRAGDYLFRLGGEEFLMLLVDTDLNGARRTAEKLRASVEREVFRLPQDRTLNVTLSVGV
ACFNGHPDYQQLMRRADEGLYAAKHGGRNQVVVAE
>A0A200NXD4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MRVSRSLTIKQMAMVAAVVLVFVFIFCTVLLFHLVQQNRYNTATQLESIARSVREPLSSA
ILKGDIPEAEAILASIKPAGVVSRADVVLPNQFQALRKSFIPERPVPVMVTRLFELPVQI
SLGVYSLERPANPQPIAYLVLQADSFRMYKFVMSTLSTLVTIYLLLSLILTVAISWCINR
LILHPLRNIARELNAIPAQELVGHQLALPRLHQDDEIGMLVRSYNLNQQLLQRHYEEQNE
NAMRFPVSDLPNKALLMEMLEQVVARKQTTALMIITCETLRDTAGVLKETQREILLLTLV
EKLKSVLSPRMILAQISGYDFAVIANGVQEPWHAITLGQQVLTIMSERLPIERIQLRPHC
SIGVAMFYGDLTAEQLYSRAISAAFTARHKGKNQIQFFDPQQMEAAQKRLTEESDILNAL
ENHQFAIWLQPQVEMTSGKLVSAEVLLRIQQPDGSWDLPDSLIDRIECCGLMVTVGHWVL
EESCRLLAAWQERGIMLPLSVNLSALQLMHPNMVADMLELLTRYRIQPGTLILEVTESRR
IDDPHAAVAILRPLRNAGVRVALDDFGMGYAGLRQLQHMKSLPIDVLKIDKMFVEGLPED
SSMIAAIIMLAQSLNLQMIAEGVETEAQRDWLAKAGVGIAQGFLFARPLPIEIFEESYLE
EK
>A0A658YZH4|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MIQSTRISLGLFFKYFLSLTKIDLGQNYISLPSIKSSTHIALLFMVSMGTQKLKAQSFFI
FSLLLTLILFCITTLYNEKTNVKLIPQMNYLMVVVALFFLNAIIFLFMLMKCFTNKQILP
TLILSLALLSGLIYLVETIVVIHKPISDSTLIQTKSNDVSIFYIFRQLSFICLTSLALFC
YGKDNILDNNKKKTGILLLALIPFLVFPLLAHNLSSYNADYSLYVVDYCPDNHTATWGIN
YTKILVCLWAFLLFFIIMRTRLASELWPLIALLCLASLCCNLLLLTLDEYNYTIWYISRG
IEVSSKLFVVSFLIYNIFQELQLSSKLAVHDVLTNIYNRRYFFNSVESLLSRPVVKDFCV
MLVDINQFKRINAQWGHRVGDKVLVSIVDIIQQSIRPDDILARLEGEVFGLLFTELNSAQ
AKIIAERMRKNVELLTGFSNRYDVPEQMTISIGTFFSTGDTRNISLVMTEADKALREAKS
EGGNKVIIHNI
>A0A6J5CVG2|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia humisilvae|TrEMBL
MRETDLAARLGGEEFAAILLDTSLEQARVVAERIRTTLQNTPVVLESGQTISQTVSIGIA
IYSESEAGLVPAQERADAALFSAKGAGRNRVQIFVPEAPAPQETE
>F7T478|diguanylate cyclase|EC 2.7.7.65|Achromobacter insuavis AXX-A|TrEMBL
MSSSSRAVPSSPDPAGQACYLSASNVQAWQAVYSSVDAYTRGQVAAVVSDSANELVDAFY
STLLADAEAGPRLSHEIVATRLHKGMKGWLKGLLCVREQGDIAALMAVQKKVGEVHARVH
IPIHLVMAGARILKNEIALRLRGSDLDGVAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQVLPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVARLDDVVLPGLLQADLAGLPDQVRELQELVARIKHLLNGL
FDMVAEIESGSDPLTNVLNRRFLPSVIGREILIATRERSTFSVLLLDIDHFKAVNDQHGH
AGGDQILRQFAEVVHQSCRSSDFVFRYGGEEFLVVLVDTARDAALLVAEKLGAEIRRHAF
TIPEVGTLRITASIGVAAFDGHPDYAYLIDRADKALYQAKQLGRDRSVAA
>A0A3S4JKS8|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MRIATITNWAYGITVGLTLASGSAMLMASSADRVERQAVQQRQVFDTLSDEVENDAWALS
DLARLYVIKPSPETLTQYQQLQQTDKSIEQRLGGLKDNGASREELALLQDGLRIADELQD
EQQAALAHVARGDAPAAIAVLYGTAYETELERMQTQIDRFRQMLEHRAAVAIDQATERSR
IWRTLSEIMVGLTALMFLFVLGFILKRRVLYPVVRLSDVVQRLASQDYAVETPHFTQVDE
IGDMAQAIRIFRENGLARQRLEQQRDADWAIRELLARMTQRLQGCETIEDVIKVAERFAP
NIAPTIPGKLYVLDTDPWQMRCVAQWLSPAGETTPFSPDDCWAIRRGLSHPPVQGEPDIT
CYHLPETHAGQSLCVPLIAQGEAIGLLTFQNVTAGDAPSRAYLELMAEALGLALANQRLR
SALLEKALFDSLTGLRNRHHLDEALHSQMALAVHTHTPLSCLMIDIDHFKTINDRYGHEA
GDLVIKSVATIVQRAVRDIGMAFRYGGEEFLVLLPGIDEAGAHQCASEIYTQVRNMTLRD
GLTEIGQVDVSIGIASYPQHTQSDSLLRAADAALYRAKELGRSRIVSFGRLKTS
>A0A3S5D8S6|diguanylate cyclase|EC 2.7.7.65|Klebsiella aerogenes|TrEMBL
MNDESKKYISVIFKEWLPLYDSLTPAVKEVLKNIAEEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLALWVKEILTSDKAQLPALAERQYQIGSIHARIGIPAEAVLRGARQIK
AGLIEYIRSHVNDRRIAVDAIYYAIMAINMAVEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPMEYGKQQAALSGWENTAIFNIVSENKANTNATLLSESEFGLWFRHKCVRYFNKNSQM
DEIAALISQVDDLLIGWRASASVMDYKNTQNLIQGIHIHCQQIGSQLGVIFSSLSQMQNG
KDALTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKGINDNWGHMVGDRAIKHV
AELLSDNIRSSDYIFRYGGEEFLLVLVETGVSEAFTILDRLRKKISQLAFNVGGDTQIPI
TASIGYAVHSGHPDYNLLLRDADNALYAAKREGRNCVKMHKGRV
>A0A0D8HTI9|diguanylate cyclase|EC 2.7.7.65|Rhodococcus sp. (strain AD45)|TrEMBL
MTSFGADRSHEILPAPRERDQSALRSAIALLVQWFRRPDQFDSFTRYLASKGLEVAVRLI
VIASCVSVAVAMLLLRFSEAGVHNQVTSVINAGIIAGTVAMIVLFSLLPALTRKWSYLFV
AYAELGVVIGVFLNRDPFIGLIQCIVFVLVGGYIAYFHNARLQAAHMVLSGVVLVLVARQ
VAVYEDPALAIALSLVVATSIVVIPFACQFVLSILGSDAESSDVDPLTGLLNRRGLQRSV
EEWGVTEANSRGLSCVVVIVDVDNFKTVNDSYGHEQGDIVLREFAVRLRRCGSNHALFSR
FGGDEFVLVDMIGKRAELELEENLRRHMRLPDNVPVVTTSIGIAIPSTSTSSYVSEVELA
GLFRLADAAMYQAKASGGDRVIVTHTQL
>A0A522LZ64|diguanylate cyclase|EC 2.7.7.65|Gammaproteobacteria bacterium|TrEMBL
MFNASPEELQAVLQQLEQAIYNHEQWYKELNRTLICQLPPDHRDVANDAHRQCRFGQWYY
NRAPQKLHDNAAFAAMEGAHERMHRLAARLLQLLETRKIVQPTDYDEFSNALDHLRLQIY
TLKHEIEDTLYNRDPLTGVESRVGMLTKLREQLELVKRRIQHCCIAIMDLDNFKVVNDAH
GHLAGDRVLTVHARYVMEHVRTYDKVFRYGGEEFLICFPGTDLKTGYTLIERLRQGLAAT
AVDHGGKAILVTASFGVTLLDPDTSVEESIGRADRALYAAKTAGRNCSRIWDPSM
>A0A200NIK1|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri|TrEMBL
MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAARLLMQDLTFSQLRTGPYSVSSQKELPK
YLSDLQNQHDIIEILTVQRKEEETALSCRLVLRELTETEPVIIFEGIEAPATLGLKASRS
ANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEIN
MLGRRVMPIMHEISHLPGGHNPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDIT
EQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHIND
LYGHSKGDEVLCALARPLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVA
KVSISCLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
>A0A2Z5SRI0|diguanylate cyclase|EC 2.7.7.65|Geobacter sulfurreducens|TrEMBL
MERILVVEDDRFFRQMYVDLLKEEGYEVDTVASGTEGLKRLEKQEYHLVITDLVMPGMSG
IEVLSRVKQKAPNVDVILVTGHANLESAVYALKNGARDYILKPFNHDEFKHTVALCFEQR
RLINENYELKELLNLFQVGQNIANCIDLERLSAVVVDAFCKEVGVSRAIGLFPEKSEPHA
LKELRGLEPEVAAALAEKALTLCSDAAETAGGFRRLDGSLFSDGLLRTAGINGALVVSIR
QRTLLQGVLLLVNDQGKPFPAVFKHKSIQFLLEQASLAFDNALRYSSARDMLYVDELTGL
FNYRYLDISLDRELKRADRFGSVVSMIFIDMDHFKGVNDTHGHLFGSQVLHEVGQLLKKS
VREVDVIIRYGGDEFTIILVETGEKGAATVAERIRRSIEDHHFLASEGLDVRLTASLGYA
CYPLDTQSKMELLELADKAMYRGKEEGKNRVFRATAIR
>A0A7W2E2E5|diguanylate cyclase|EC 2.7.7.65|Pectobacterium aroidearum|TrEMBL
MNELLNVNEQRDNDELDYNQVITSEWTQLIATTSQKSFNLLRTISEQKASDFADKFYSYM
LKDQEASLFLSSQQVHDRLHGSMSKWIADILMNTGEHLADLINHQKKIGQIHARIGIPVD
LVERGARRLKWHLYEDIAQVAEDKALCFDAMRFASISMDIAIEIMSKTYSQSHDLAAKNE
ESYRLFSILENASMERERQNASLLNWENAFIFSVATGTPLSSIQDLSDSEFGLWFNHKGK
SSFSNIQGIRTIASIIMETDEYIRGYSTTALLTQQDYAPLLKAVRSKIYKINMLLGSLFD
EVQKLESGKDTLTLLLNRRFLPTILRHEISLAMHSSTPLSIAMIDIDHFKTVNDTYGHAA
GDNILKRIAEVLYESTRNSDYVFRYGGEEFMIVLIETPKVAAHTIIERLRKKIQDHPIHL
QNGESITMTISAGIAVYNGHPDYECLIKAADDALYQAKANGRNRIEYAQEE
>A0A7W8JHL7|diguanylate cyclase|EC 2.7.7.65|Anoxybacillus mongoliensis|TrEMBL
MIKQFIANSGILIAGFYLISKFFPSNIHKQSPFHMRLFAGAFCGLLSIVLMFFSIPLGHG
VIADLRHVPLIVVSYYGGMPSALTAGIIMGAGRFLFGNTFASIVSFFISLAIAIGCGLIS
RWMKRNIAVTTFWMNVYSMCFISFALFINIPDRHMYTETLFVFWPVSFFATYIAANICKD
IRQSKDLLQHYKAWATTDFLTGLYNVRQFHTVLNEKMAQVKQQNSCLALILFDIDRFKSV
NDVYGHDGGDVILRHLGELIRSLVPKNALAFRNGGEEFSILFTSCEHEAVTFAEHVRTTI
ERHPFVVQKQTVHITVSIGISLFPTLATNETELFKQADIALYEAKQQGRNRTVVYKKGTL
A
>A0A5E4S5S1|diguanylate cyclase|EC 2.7.7.65|Pandoraea eparura|TrEMBL
MTTQRPPSPPMPPGSSSVAGLLPADLSADVSTEGEREPPLATPHVAASAPARDRRPSLQR
MLRRTHLRLAVSAVVLAAVSLSLVAWIALRVYAENNLQLIGRSLAYTTEAAVVFGDRVAA
QEAIALIASDEDLAQVRVLDANDAQFALWRRPDGGALTQVERAVASVALPGPATLPIRHD
GKVVGSIEVQGQGHQFFLFLLTGIGGVLACLLVTFAVANVLAKRMHRDIVKPLRALAEVA
HAVRRERAFHQRVAPTPLAELKELGDDFNALLDEFEGWQNHLRAQNATLAHQANHDRLTG
LPNRAYFESRLAQALTDAREMGTHVALLYLDSDRFKEINDQLGHGAGDAVLVSIAERLRQ
PLREGDLVARLGGDEFAVMLVGVRQTSNAVRLAQTLLAAMEKPITLPDGREIVTSMSIGV
ALYPTHAVDAAALLRTADAAMYQAKRAGVGTWHVADIPKGDAEVQRAS
>A0A4R8R408|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides franklinii|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRAFLHARKLDRTVRNLIGGYALIFAAICVAVQ
FSDTGPRSTSGRIIVGVCALGALGWAVRWVVGPWPSLREAVGFVVFADVGIAIACWQDSD
PLAGLVGTVLFTPVGAYVSFFLGNRLLVAHVAWCAPMILALSSRLLAAGTVGAAMTAVVK
MTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYGEWQRLHNGLTGDRIL
EGDRVIAVAIVDIDRFKSINDRYGHGTGDRVLVGLAGALTAETAQGNLVGRSGGEEFLVV
TICPAGSVTEFATRLKEAVTASMPAGIAVTASVGVAAEPVASVALATSQEAIDALTACAD
RAMYEAKRGGGNQSRILHPGVGVDDQCVWRAGI
>A0A1C3JBE6|diguanylate cyclase|EC 2.7.7.65|Vibrio celticus|TrEMBL
MNKDEFQKSTANLKKAVPLMMKNRVSTTPANYALWYTYVDNAIPQLTQDMDGVLEHYGIC
PPAVGEQLYNNYVACKSETSINDLRANLELLVSEVSNSMNDTLTDTSAFSDMIDKSFEDL
ARVDNESLSIDEVMSLVRQLVSESRHIRHSTQFLNSQLNSATSEITKLKTQLVEVQKDAL
FDSTTTLYNRRSFDRDIETLCEAQQSLCLILLDIDHFKNFNDTYGHLFGDMVLKGIARKL
KLSCREGISAYRFGGEEFALIVPNKSLRIARQLADTNRRSLEKLSIKDRRSGEQVGSITA
SFGVAELEPGESAQSLIERADKLLYEAKSLGRNRVMPL
>A0A1W6LP14|diguanylate cyclase|EC 2.7.7.65|Sedimentisphaera salicampi|TrEMBL
MKTEDDILIVAPEGRYWGLPDNIAGRLAVSECPAWGQSRAKQPSKIFFILDSAADFGFTK
LAETASNFPEASIYLLGETIFEPIMQRVSDKGVCSGYYILPLTESEFSQILENGKLDSVE
SNSYEARIRKLSTIAYCDELTGLRRRRFFTEAGNQILRLSECCEIAVSVFLFDIDDFKKY
NDQYGHLAGDQIIKDTSNALRNSFRPHDLLARIGGDEFAVMIWDFEIKNESIETGGDERR
HYYKHPVKSSEISRRISENVVEVETSRGRLTLSGGMASFPEGGSDLHKLLESADNALMKA
KKSGKHTILFS
>A0A446ZEX0|diguanylate cyclase|EC 2.7.7.65|Acinetobacter calcoaceticus|TrEMBL
MKSRLITRPIHRIKQVIIDFIHHNHIINWTPLQKSALMLTLACAMNFSWILWKAYILITP
DIWQWANLPLVESQIRLNLFTLFLLVLLIISCYCYKNYEWAQRIIPFISVQFFALMLCHD
GYLIGSISPATMVGYVGTIGVGLVLFDRKIVYSALVPATIILTVCTYLSMRGTLSYAPLF
NLIAMQRAQTNPFWLGSMAFFIMPILLACFVLFEILLTQWRQRETYIQRLSQLDPLTNVL
NRRSLNTHLESLHQQQFDYAVVLLDIDHFKKINDIYGHHQGDQVLIEIAQCLSKNLRNED
IIGRFGGEEFILLLPHTDIIQAEKIAERCRHALEELPVFSAQNNPIHISASFGISSSAFA
QDPYLVIRQADQALYAVKASGRNQVRTFHQIEAINTL
>A0A0T9SYF8|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MPYSTRINTRRSGLSFAKRTYLPRAFGLGIGMLCVSSVLYTQNAPLWLWIALALNGLVWP
HIAFLLASRSEEPFEQEILNMKIDSALGGVWVAIMSFNALPSVVILSMMSMNNIASGGKN
VFCKGLALQIACSLLTAWIFNLPFEPETSPLQVYACLPMIIVYPSLLGLVTYRTAKRLAE
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYQHGATLILLDIDNFKSINDTFGH
AVGDDAITVLAEELLLGLRAIDIVGRYGGDEFGAILPNTTAEQTREVLTRIQEKLADLVF
AQAPSLQLRVSAGIADYRHDMINYQQWLKAADSALYLAKDNGRNRIELAS
>A0A0T9U1J9|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSEIESLSTLYRDVCVTYATLSISYFALSKSSAFSYHGEVWKRILFGLVAGLVSLYLNQD
QWVISGSFFYSFELIPIVLVTFYGGWLSSLTALVINFAFTGWVTLDNVLITIIFIPLLLS
RVWEKKSNRIFYITIILIAFYRVLAALLFVPNALIWTQIVVYQLISALCLAICYHALNFK
ERYIYAYFAMKNRANIDKLTQLNNRASVDYRLNTIHSSRQACGLMILDLDHFKLVNDTYG
HDGGDLLLTEVGKLLTSSVRDEDFVGRFGGEEFIVITHSHDPQTIKTVAERICQRVENLN
VELPDGRKIKTTISIGASLYLPGMSMLKAMKMTDEALYQAKKQGRNQVVYSRLMPFSPLG
DRINREGRRRRS
>A0A0T9TAB3|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MSSIKKQSATRAPDHHNATKLPTLGRVLGRIHLTVVLVSVTTAGIFLTLAALFALRVYAD
HNLHLIARSISYTTEAAVVFGDKVAANESLSLIAANEEVAEAKILDVNGREMASWTQPDD
GPMHYLEQNVARWALPQPVVLPMVHAGNEIGTIVIVGHGGSLLRFLLQGLAGLLACLLPS
TVVALVLSRRMLFGIIGSLNQITDVAHNVSRNRSFGQRVPSAKIAELNELSSDFNGLLEE
LEVWQEHLTQEHDSLAHRAAHDSLTGLANRAFFEGRLSRTLSDCKPGDHAAVLFLDGDRF
KEINDNYGHAAGDVVLTTIADRIRALLRETDLVARLGGDEFAVLLAPIHKTDDVLIIASN
IIESMSQPIVLADGREITTSLSIGIAIYPDHAQTPEALLQRADEAMYQAKKNIQSGGGRV
IAHPSDTPLTESLG
>A0A0E1NBK0|diguanylate cyclase|EC 2.7.7.65|Yersinia enterocolitica|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNAASAIFSMILPSPEVPAVTLPLVMIMVISLSIAAY
FIFISKNYVDKLNLFSIIMGILWAWQIILKYEYLGTNENNYLLLSLFTIFFISTIALSDN
FLAFCLHTAPAALTVIFLDDFQNIFRIIFTIMLPLIGFSLHHLMLRRSDDFTRKLVARLY
NEREKFSDLSMIDPLTSLYNRRGLENKLETLLAQSPGNHYVLLLDIDHFKAYNDNYGHTM
GDQALVRVAAAIRDAVRSRDIVVRYGGEEFLVLLTHVSEEYASQLAERVRERVLGLDIPH
VFNHKVSTTVTLSAGISPLQPYDLASSLKAADEALYRAKKDGRNKVAFAEDKLSKIESSP
>A0A6J7ZHB2|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MKVITLGRSILVHKCLSLIKTLTEWIIRQINFMQYPDSQNETADLIESNSNNNGLLNHSF
QTKERVKQLLDSSQVVIFSCQPQPKYPITFISNNVKILLGYDVAILLRENDVWHTYVPPS
DQDKWQNAFVQLLVKGNYIHEAQFLHFNGNFCWLRVEMLLIKDEGGNISEILGYFVDITD
RKEAEMQLSTAENRLKTVIETVGSGITLSDQKGNFYIFNSKMTEITGYSLEDAQSHSDFL
ALLYPGSKSYSQAQSRLDNVALMGSIFNAETTIPTKNGELKTLLLSTVMMEDQDNPLFLS
TFQDITPLKRAEKALCQMIVQEHLIWEITHKIRQSLNLEDILNTTVTEVQQLLECDRVFI
YRIFPNRQGKIIAETNPNELLKTQPSPTPLIPLDCYEKFSQGGIRVLNNIHHDPTDPEMF
KVIKYWGIDSAIMVPLLEMNQLWGLLIVDKNQGLRHWLKWEANLLRQISEQVGIAIQQGH
LYQEIQDQAHRAQILNQVIQVIRQSLDLDTIFSMAITEIVSVLGLDRACILQYLPQQKQW
QEVACFGDHHSIIPPVFSPMQQTYCLESDDFNVLTSEEIQHLTGILGNWLPIPLRVGSEI
WGCLGLLKQQNLNGWKESEIELTCAISEQLAIAIQQSKIYQELQIANQQLLRLATIDGLT
QVANRRRFDQYLEQQWQDLQAEKSSLALILCDIDYFKQYNDYYGHLTGDSCLKKVAQALE
NILRDPVDLVARYGGEEFAIILPHTSWNQAIKLAQHIQNSMLQLQLPHANSRVSQWLTLS
LGIACTIPSDEISPSALIGGADQALYLAKQQGRACYCTHEMDAI
>A0A6J7ZMN5|diguanylate cyclase|EC 2.7.7.65|Planktothrix rubescens NIVA-CYA 18|TrEMBL
MVDLEQSEEQLEQEVQDLRYQLEIAKETLRAIGNGEVDALVIAGLEGEQVYTLQGADSSY
RMLVEEMKEGAATITTDSTLLLYCNKRLASLVKTPLKNLIGTDFKEFISPSDLTLFQALS
QKANLGSGKAELTLIARDGTEVPVYLSINILNQKGVEVGCLIITDLSEQKRDEDIVAQER
LTRLLLEQAAESIIVCDHQGKIIRASQEAQRILGANLLLSDFDDLIKLELLPQQNGGHSL
RKKEKSSNSIFSIASVINGHPYKGREVLFIRKDGEKINFLLSASPLSKPHSVFKGCVVIL
TNITERKWSEESLKKINEELEIKVSERTAELESLNSRLKQELVEQARTQQILQDQAQLLD
LANDGIIAIDLNDHINYWNQGAEKLYGYSKSEALGNNLVELLKIPSPQALEKIKQEVLEK
GNWEGELIQTNQQGNTVIIHSSWSLKKDSEGNPIAILKINRDITKAKQAEQAIIDSGLRL
AGILDMAQDAIISINEQQQITLFNQGAEKIFGYTANEILKRPFSLLISEFSFQKDCQYHP
ELLPENRLIQDIGEYQEVTGYRKDGTEFPAEVSISRLSLEAGKILTVFMRDISDRKRVEI
SIQKAQEDLEIKVQERTMQLATSNDELVREIAERKLLENELHEVNEELEQRVEQRTNELA
KAINDLKEEAIERQKTTLALQESEARFRAAIDGSLDAFFLLQSYRDTEGKLTNFVLVDMN
SKAEELLSQNKDNLLGKKLNDVFYQESNLGYFDRYLRAFRTRKGFEEELEVSNPNIKGKW
LQIQVVPLSDGIALTCCDITERKQSEEAAQQANQNLTRWVNDLEQRNRETMLLGQMSEFL
QACNSTEEAYQVMNDLLKPFFPKISGGLFVARNSKNLVEMVAIWGDLQGISEAVFSPQDC
WALRRGRSHFVPATTSNLLCKHIHQKNHRQYQLNSNNSSEIIPKPPEKNKLPATYPVMVE
HLCVPMIAQGDALGLLCLASEESGQISADQQRLATAVAEHIALALANLKLREALEYQSIR
DGLTGLYNRRYLEESLEREINRAQRQKFGLGIIMIDIDHFKNYNDTFGHNGGDIVLQQLG
NILQKNVRGSDIACRYGGEEFTLILPEISLEFVKERAEQIRVEVQQLKPKHRDQDLGQIT
LSLGIAMFPNQGLTGESIMRAADTALYQAKEEGRNRVCVFGSNFDHYT
>A0A128F5L7|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MSFVKLFTFTLVLVSIGYQAYNMMHSKQLIKILDEDYRHLYSTIRRFGYFYNNSSSEMME
AGIHKHGDISIIVLEKPTEVKNLAPGLDKLNERLQQFVPGSIWSISILENVSNYGLFMPL
RPGYQELFSKNKKTKNFERLMTREKLNNTYQEFYGCNTRMTEVYVESITNARIRTIYFPI
HNRESLDAIVAVDIKASLTDTLVDKYNDQNKTVLSLDDASNIFKSEGRLPCTTDKKIEIG
SNFTNVLKASLWPSFLLSVLTHIIYCFVHRHGQFIKKDEMTGLYRRDYYEPKFKRVNKFS
LLVIDIDHFKNINDTYGHTKGDEVIKICAQIIMSQIRSEDIAVRWGGEEFIVMFKDMKRN
SLFDKAEQIRESIALDDIAGLSVTISIGGYTANNISFSEAYKAADGALYQSKHRGRNKVT
IA
>A0A128FBT4|diguanylate cyclase|EC 2.7.7.65|Grimontia marina|TrEMBL
MFQTQSPPQMQFFELAPVPMVLLNELGEIIQSNRECLQLFHGQPDETNIDGYLTESAWNE
AVRYFEVVSNSPQYEPFTKLVRLALSKDIYVLKVNLVNTVPTNTFIAVFTLYQQDDEVNE
ALQERLPMGMVRVDTEGRFISFNPAYLDLLGYEVDDLLQITEFDLTYHSDANSERPLREN
LTLGSGNQYRVDKRYIHKNGHQIWVRVFVSSIVCKYTNQQQYLVAVLDIHEEKQLQETIM
TSERRFRAIAENVSSVVWISAADPMRLFYVNKCYDTIWEERVEALYSNPHAFLAKIHPAE
REMAESTRFSSSTDSWNINYRLLFDDGRVKHIRDSGNCVFDGNGELIYRVGTLTDITAEI
DQRDTVVVMAKKLRELVEYDSLTGIKSRHAIMTDIQEAFQGYDRVSDASVLVYIDADGFK
SINDSYGHDVGDKVLKAIAGHLTSNIRDSDVAGRIGGDEFVVLLRHTAKAEIPHILERLK
CDIECEGLPEGVKVSISVGAVELSEKVISVEQWLSEADKTMYQHKRARKKSRLSRKY
>A0A5T4ILZ6|diguanylate cyclase|EC 2.7.7.65|Salmonella montevideo|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALMLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A084A4T5|diguanylate cyclase|EC 2.7.7.65|Serratia sp. DD3|TrEMBL
MDISTVTPPSKKQGSVFTHALLTAIIVFLLAYICLTLSFEAKAFTPLWFPTAAIIMQLYR
RPRHSWGLSLLFSGTAICAANFLLFGLGWLPVKLMLINLLGASLSTMLLQQILPANDPLN
SLVNWLKFVGCAVIFTPLITALLAATVVAKPEVSFWRPVGTWFISEAIGVLALAPIGLVY
RRSMLKIDNLFKLLLVLVGTLVLTYLALLNLPFPFTFIIPPLLLAALSLPRLETFITGFA
ATLMITIMTSLGVLDLQGRLPFLSDLEVYMPLLLILIPAHAMAMVMHTLRVEKRHIVESE
TRFRNALEYSAIGMALVSPEGKWLQVNQALCKLLNSPAEALHHLTYQELTHPSDLESDLA
QRQDLLANRISSYTMEKRYLRQGGDSIWTLQAVSLVRNAKNHPLYFIFQVEDISELKRTE
AENRRLVERITLANQAGGIGIWEWVPSEKKLNWDKRMFELYGLAADQTPTLKLWQSMLLQ
EDRERIKQQMMAITEHAQAFVMEFRIKKPSGEIRHMRSQGNVILDKQGNQQRIIGTHIDM
TEVKSLTEALHQEKERLHITLDAIGEGVISTDSEMCITFMNPVAEQMCGWPLAQALGMPI
NNIVHLTDGIDGPKVENPLLYTLQAGKALPSDNSLVLHNRHGHCFDVQESISPLKTIDGD
VVGTVIVLQDVSAARELMNKLSYNASHDALTNLKNRTSFEQQLKYAIANARDNHQRHVLV
FLDLDKFKAVNDSAGHAAGDALLKEISQLMLRQLRNNDCLARLGGDEFGMILFGCTLENA
QTLMQQMITQIKEYPFYWEGKIHHVGACAGITAIDAQSGTSEALLAEADAACYKAKNGGR
GQVYRYQTDESSD
>A0A7Z0Y292|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. diarizonae serovar Rough:r:z|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFAALQSAVTQFEQRRARHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRDNRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVQWFTSSQPYIAVEQQKVTA
SVPLDHDNYWYGVLAMDIPVASFQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A083ZWA6|diguanylate cyclase|EC 2.7.7.65|Serratia sp. DD3|TrEMBL
MKVKYLIYLFTFAIMLSFSLFVFNALRIANTHYVQNESNLYKLQRTKDISEAFQAVLSAH
RLKRLSQINQTITEAQWRDADEQAHDKIAIMKSHAEHKNQNFQSVNQKFTLLSMISLLEK
LLDNDVQQILQSNNPATAHLFNINSAYYIVQANKAFYQYSYDPQMINAESLLFIESISFN
NLLTLSLTELIDQIIDVNLSSLERKDAYLKAIQLTGVIKSLNTRLTFIEQTYNDPKISSL
VDSIKKHISSDQLNYISQGLYQAIDLNSSYNADSIYQYINEINQLSQPLYQRSFELQIAA
TQNKLYHSQTTIYGLIALTGLIILFVLLPLLIFCSRITRWLTKTHNNILRLSKGDTSIDN
NEVFYSQELVAINDAVTQLKQYNQVKLALEQEKHQLIKDLELSSFFDPLTNIYNRRKFFI
EYNLLPANSYPHTFCLIDIDKFKRLNDTYGHDIGDRVLVMFAELLRNHFRASDIFCRYGG
EEFAVLLNRCSQEEASRLMNQLRELAEQLCLELPTGKRVRFTISCGIASVNNIEGLASAI
KQADEALYYCKKSGRNRVSIYTSQGFIP
>A0A0J6WK49|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium chlorophenolicum|TrEMBL
MRTTSESSTQGNSGRHVDTAEERYRRLVDLSPDPMCVHSDGRVVYVNPAGVRGFGADSAE
QLVGRPIIDFVHPDSIGSMLERILALSDEGDSSPASEAVLRRLDGSPLEVEVVSVLTTWN
GEPAYQVIFRDLTAQKAAEAALRYQAALVNHVSDAIIATTADGIVTSWNSAAAAVYRRPV
ERALGLPLVEAVDGDVDLADIVAGGGVVHARHRAADGSPVNVRLSVAAMDDGYVVLCSDY
TAQRRAEVHFESVVRSLHDGVIVLDRHGKPQSINPAARHILRLGTAGLVADYTSGALTFP
VFNYRGVKIGDNELGSVKLMFANAPLENMVVGVERADGTHAWLSVNCCLLDPADTENSAL
LVSFADITAEHNAKAHLAYQAHHDPLTGLPNRAQIEARLARAEKPGAPHLSAVLFVDLDD
LKAINDDLGHHAGDGALRETARRLRNSVRDGDFVGRLSGDEFVVLLYGCLDRAALEGLTA
RMHGEFAEPIYVSGRLRRVSVSIGVTELSAADERDVEDILRDADAAMYQAKILRRGTSFA
>A0A753FXR9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi C|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A379YBQ4|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MLRPLISLSLTFWLLLLPLSHAMAEEKTQVDKIFERFESGETMTREAIKSDLALLSKLIA
TDDVARNEKLQLLKCWDQSAETDTDIALAVKNTSQTLTNIPPTASPHFITDLMLCHSWFL
QLNGDVDSAMEGYNLSVKRAYEHEDLKLIADSRSLRGALYSYIGDFSAALDDLITAQDLY
ESLNLTGWANINLADMATSFRRYGDPQSAIRYYTKLKALYLKNNNKEQAMYVTSEIGLAL
DELGEHQQAIDNFLLSYQYFKEHQLEKAAATMATNIAYSLIKLNRLNEAEKYLTEAAAVI
NEKDLADYSFMKLFMGNIKFQQAHYEEALTELEQGEKAFRTLQNDRGLTQLLQLKSDVYA
AMNNLPAAYGALLEFVALTKKIDDNSFSHQTTELKVKFDTTRIESENQRLIENQNLKEQE
LALLEKNKSLQHIILLLTGFILTIVSIFAYKQVQRNRQLQVIALTDYLTKLPNRRHIYAQ
AAQYFQQALKQQSPFSVIIFDADHFKKINDNFGHELGDRALLTIASAGKALTGNKDLIGR
IGGEEFLILLPNTDAERACELAHQLQAHISRLGAEDLPAELKLTVSAGVATLAPQTNTEN
TYQDKDFASLLKRADDALYEAKNAGRNCVKAAKNEATCES
>A0A8G2EG28|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasipneumoniae|TrEMBL
MDKPLRLKLKKRYFLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALERPLDVDVLHEASQRYLNQRHQEIWRVALPNRRTL
PVFGVSESVVREHPLLLPDDPLVVNELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVKTHYSRAISALWFTRQTQRNNPYRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLISAMKGGQEGEYQLYDSHLSLLASSAPGNVLTLLSPR
EQELLSRAFAHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WILFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEKAMALASACQR
SGLPLAVIQLDLDHFKSINDRYGHQAGDRVLSMVASTLAGTVREGDLLGRVGGEEFCVVL
PNTTLQEAAAIAERLRLRIHGREVFLHNNVTLRVSASLGVSASEEQGEYHFEALQSVADG
RLYLAKQNGRNQVCFRSEALVKRFARASGFEIYLKVMSGDRTIG
>A0A0E8XK17|diguanylate cyclase|EC 2.7.7.65|Yersinia wautersii|TrEMBL
MNTIKNQSMKPKKNHNSAEKLPTLAGVLRRIHLSVAIVSVVTAGIFLTVAALFALRVYVD
HNLHLIARAISYTTEAAVVFGDNVAANELLALIASNEEVAEAKIIDKHNRQIACWTLPDD
GPIHHMEQIVARWILPDPVVLPMFHAGDEIGKIVIVGHGGSLLRFLLQGLAGMLACLTVS
TLVALFLSRRMLLGIVGSLNRITEVAHNVSRHRSFGQRVPSAKVAELNELSNDFNGLLEE
LEVWQKHLTQENDSLAYRAAHDSLTGLANRAFFEGRLSRTLNDCQPGEHTAVLFLDGDHF
KDVNDNYGHAAGDLVLTTIAVRIRALLRETDLVARLGGDEFAVLLTPIHNLDDVLTIAEH
IIDSMALPIILAEGGEITVSLSIGIAVYPDHAQTPEKLLQRADEAMYQAKKNFRSGKRIF
AYQPKTTHTKILG
>A0A7Z7RIB2|diguanylate cyclase|EC 2.7.7.65|Chromobacterium vaccinii|TrEMBL
MNPWPFSARRIRKELTLILLLNLGCYLLFIHWDLFEKLDIWLHQHPASQLDEVLLLSFTL
ALSMTWFAIRRLREARQLLKALRRQAERDDITGLANRRRANQALQRETERSRRSGRRYSV
LLIDLDHFKHINDSHGHLVGDKVLQRFGQVLRQRARQLDTIARWGGEEFIIVCPETEQDG
ALALAESISQLLRETDFDPALRVTASIGVATLADDDTPDSLVHRADICLYAAKQAGRDQV
VGENHSPATLP
>A0A0E8XI28|diguanylate cyclase|EC 2.7.7.65|Yersinia wautersii|TrEMBL
MNSHSYDQLLKSKHRLSLLLFLFLNASSAIFSMLSSSPKTPAVTFPVVMIAVISLSAAAY
LIFISKNDAGKNNYVDKSNHVDKNNYANKLNLFSILIGLLWAWQIILKYEYLETNEDNYL
LLSLFTIFFISTIALSDNFLAFCLHTAPSAITVILLDDFHNIFRIIFTIMLPLIGFSLHH
LMLRRTDNFTRKLVDHLSNEREKFSDLSMIDPLTSLYNRRGLESKLETLLSQSPGNHYVL
LLDIDHFKAYNDNYGHTMGDQALVRVSAAIRDAVRSKDIVVRYGGEEFLVLLTHVSEEYA
SQLAERVRQRVLGLDIPHVFNHKVSTTVTLSAGISPLQAYDLAASLKAADEALYRAKRNG
RNNIEFAKDELSNVQSSP
>A0A448EIY5|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MNKLKQTLFWCFLLFIWTLSPSVLSAEIALDSPYLFHAQADQQPPKQFDAVPHWMGQLDE
ANSVSLTGGDYWMITPVMVNQRQSNWVVDASNSIIESVDYWILGSDGSTQHAHSGYTAPY
EFLFDYGRKVTLNMGTDYWLLVKLSSRYYSSPPEIALQSVTDHQLMSDRLAMAVLLCLGG
LLFIALYNILIYISILDKAFLYYGLYVFAYFAGWALTFHLPAHLFNFHYLELHHLFFISL
PIFNIMFYKHFLQLPSYSPRLWRLSQYLMFACIVALPTSIWLLPYTAIIASVLIMLWIAL
AITCGNVCLMKGFAPARYFILAFTCLLLPAVIILPGNMGLTPDFIEHAELATLMGGTADA
LLLSLALANKLKLLAEERKAHIEELAIAWEKARLDGLTRVGNRYAFDEYMNSQLGFADKV
VQPMALALLNIDSLKSVNETLGHQEGDRLLQSIVRLLQATDLAHLKLYRISGDEFVVVTP
SVGIPLLLSSLNGLGEQLASQGFKDCQCSFGISLNSEVADPHEWLRSADTNLYQSRMDKR
RQEYADTRGVDVRLHLS
>A0A3S5EB58|diguanylate cyclase|EC 2.7.7.65|Shewanella baltica|TrEMBL
MINIEQMALILDALPDPALILSKSGRYVAVFGGKDGRYYHDGSGLVGLYIADVLNPDKTN
YFLGIIEQALASRALLIEEYELSNKDVKGLPDAGPDQPIWFEGRIQALDFLVNDEPVVLW
VASNISQRHELELQLRQLSDTDQLTGLYNRRRLERDLTVQFDTFQRHRTPTSILILDLDH
LKSINDQLGHHAGDKIIIAVAETCRTQFRKTDSAYRFGGDEFVIALPGVEQSQAVKFAEY
LCDCFYSALQQHAVNGLFATVSIGVASIEALDTSYEDTLKRADAALYQAKRNGKNRVISN
TA
>A0A3R8VPE1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas saudiphocaensis|TrEMBL
MQQISNEQLAAEWQSLLQRFPVQAGIELKAVAEANSQELAEHFYQQMLADPQAALFLSHE
QVQERLSDSMERWVQRVLSANGDEDLEPLIELQRTIGAVHARIEIPVSLVLRGARHLKGR
LRTLIEARVKEEILRRDAARLGADIIDLAVEIICFAYSQSHDRNSRAEEAYRLFSVAQNL
GAEKERQRAALLDWENQLMFNLAVGSSLSSLPRLTSSEFGLWFRHKAAHAFQGSPNAAGI
LETILKIDKELQLLGEAGVDQGNSTLHSIREKTRSIRFLLDNLFEQASELEAGRDVLTRL
LNRKFLPVVMNKEMLYSRQAGGSFGVLVIDVDNFKQINDRYGHDGGDQVLLQIATTLSNN
TRGGDYAFRLGGEEFLLVLVDVNTEKVMKAAEKLRSHIAAERFRLPQGEMLNVTVSIGVA
VHDGHPDYEYLLRRADQALYEAKRNGRNRCVLAPSS
>A0A1J5RJ25|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MPTAAWLEQLPACVVVIIAGVLRYANAAALHLMEAQAPGDFVGRPVVDFIHPLDLHRVLA
RIRRAEQAAGANPPTEFRAYSCRGRTLMLAMSSTHLREGGAGSVLASFLDMTERAAMETR
LRETEENFQRMMNTMQDVFYRTDAQGTTRYVCPAVKNVLGYSAEEIIGLPAAAFYPDPGE
REALIAAIRKHGFVRDFPGRMRRKDGTVIDISISTQALRDEQGQYAGVEGIWRDITERKN
MERELERLATRDSLTGKLNRRCILERLEQALDQRRDRREQPSLFVLLMDLDHFKRINDTH
GHAVGDRALCQFVETVERQRRGDDHFGRLGGEEFLLILEGVDLAEARRTAERVRLAVERT
NIELVEGLTTQLTVSIGIAQMQPGDRRPSDLLERADRALYKAKHRGRNLVCA
>A0A1J5R388|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MELYDITREDLQDMLSQLEQARFHHQLWHAAMVRVLACRLPADQHDICSESHHKCRFGQW
YYSERSSKLRNRSGYIALGKAHKFMHQLAAKLLIETSEGKPLVTFDFDNFSNSLDRMRLE
ISALERELENALYNHDSLTGAINRTGILPALREQQELIKRELQSCCIVMVDLDNFKVIND
LHGHLAGDNVLTASAHYLIEHIRPYDKVFRYGGEEFLLLLQHTELTLGFNMVERLREEFA
SMPISVKGKEPIHITASFGITLLDPATPVETSIDRVDKAMYAAKAAGRNCVRIWDTTM
>A0A1J5TNH4|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MLTDNSNIQYRFSDLIDVPAFARMLENFFQATGIPNGVVDVDGNLLSMSCGNNACATFHR
VNPEATERCRDSNIAIMHDLRNGHVAGGLCRNGLMDYATPVVIEGQQLATLFLGQILHTP
PDMEFFRAQATQFGFDEKTYLKSIQAIPVIEKAQVESLMTVMVDMAKMLANCGLIRLRQT
ALEHDLNEHAERRIQLEDILNLSPVAIGWSNGENRIEYVNLQFTLLFGYNLDDLPDLETW
YRLAYPDENYREMVIRPWMKNVATAKTSRTQPPELEVNITCKDGTTRRIVIRASWIGQRR
LVNFTDITDRWISEQRKQAHDTMLEMVAKGAELADILNAIVRQAQSEDKTTLCSILLIDE
EGKHLLSGAAPDLQTFYTEAINGLEIGMGVGSCGTAAFLGQRVIVEDIQTHEYWKPYTQL
AQKAGLRACWSEPIRSSRGKILGTFAIYHTQPKSPELEDIERIGAAANLASIAIENRYAY
EELERRAYSDYLTGLANRRFFLEQAESELSRALRYDGELSILMLDIDNFKLVNDTHGHKI
GDLVLKKLSDICRNTLRDVDIIGRIGGEEFAVLLPETGSTQAEEVAERLRAAIDSTRVSL
DSGLPLHFTISLGVTTLFDKDINIDTLLNQADQALYQAKNSGRNRVCSYHVTNSSSD
>A0A1J5RG15|diguanylate cyclase|EC 2.7.7.65|mine drainage metagenome|TrEMBL
MSLAAPLSRAHESVATEALDLIADDTPASALAREQAELILRSIPSAVITTAVVMTALAAL
LRRYYAWQRIAAWLAFALPLFLARLAIWRRVMRGRALLTRPRACLLQLQGSALLAGLTWA
PLPLWFFAGDDLLRMFLTALLLAVASAAMAALAAAPLGALCYMLPVLAPLIVRLMLAQQP
LLHAAGWMTVVYIAFLLLVSRRMRAMLQDKSSWRLDAVRRSLTDPLTGLSNRMGFEQRLD
AALHRARRHGSGVAVVFIDLDAFKAVNDQHGHAGGDRLLIEFAQRLRSVLRANERPARIG
GDMGGHEGVACARNARDHNRRGLQRMTACRSARSASAPTIGNQHTERATLQQPLRRAH
>A0A378ULK7|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium aichiense|TrEMBL
MYKDVGMAAWVRKWWHQPGQYDWLSDYLAVRHLQRFSRILIASVVIVLGTIPLVMLFSPS
GPQGEAHRTAAIVMSALSFGGASSWLAGWPSRRQSALFAVGANAGVTLAVVIAGTPATGL
LACATFAPIAGYVGLYHSGRLLAATLANAIITTLLAGARIAAAGDTAMAVGHVLGVLIAV
LAVPFGSQLLLHLLSLDARMSSTDPLTGLRNRRGYDESALALIAAADRPQSQWLAVILID
LDGFKQINDAHGHGYGDTVLVAVADNLRRASAMKSVVARLGGEEFLIAELIEPDDAAGTA
ERFRTAVAAAGEVTASVGVASVALTEIGSAATTALTELVNAADAAMYDAKRAGGNQTRHR
AKSST
>A0A5U8V610|diguanylate cyclase|EC 2.7.7.65|Salmonella typhimurium|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAA
>A0A1C6L4Y3|diguanylate cyclase|EC 2.7.7.65|uncultured Eubacterium sp|TrEMBL
MNVNMTAEEFCRFVWQKYLVERRYDIMDEVIDGQISVIGTGAHEMCPNIESFVASITRES
QEWNGAFIIKDQWYQTTELTEQLSLVIGELAVKEDGNDGILYDVRFRFTMIVRKTESGFK
LIHVHQSVPDANQAHDEFFPHRMIEENSSQVIYNLRHDTMTGLLNRLYLKEIVNRAMEED
TDSIMLMMDIDDFKSLNDRYGHPFGDKVLVLFAQSLKAAFPQAMIGRIGGDEFVVYLTGK
PDRLKDRIDRFLLDWQESQAVLALTHLITASIGIAEVPKDGNNYDVVWEKADQALYQAKE
NGKAQTASVK
>A0A1E3L1T3|diguanylate cyclase|EC 2.7.7.65|Paenibacillus nuruki|TrEMBL
MRLYPKKGFKLVTIVSTIIVFSILLTMIISVYSAYLVSKQALVDNYLESNYQHASELANA
AGNVLDTMQESVDGLATIWQRGSKIDQDLLEDLYSNNKNYFNSIVIVNKKLVVDNTVPAT
SGVTAGQQLSGPINNMLLEIRIPHITEPFRSKDGRWIVLVTSPLFDKQERYYGYIAGTIY
LQKSNVLQGILEHDYSSDGSYIYAVGPKGNIIFHPDINLVGVSKASDEAVWKVMAGLAGK
IEFTDQQDQTFYTGYAYNMKSSWGVIVQTPASVIDVPLRELLQKSILLSLPLLLITLAAG
WIITYLAVRPLHVLAEYSNRMVNDWRSEALPPINSGTYEVKALYQSIRFTTRQLQKYIMK
LKNETALDGLTGLANRRNFDSTLEAWCIGDEPFAMVMLDIDRFKRVNDTYGHLTGDRVMQ
FLAVIMRNVSREGDVCFRYGGEEFGILLRGCNVTRAYIVAERLRELLQGTVSPSGEIITV
SSGVVAFPEHGRTPDDLISHADEAMYTSKREGRNRTTIYYNQPIEVAEEVEKEPTPEEIN
V
>A0A1C3HA61|diguanylate cyclase|EC 2.7.7.65|Serratia marcescens|TrEMBL
MYIAPPIFDARKSGLSFAKRTYLPRVAGLGLGFICVCASLYPLAPPTAVWLLLAFHGFLW
PHLAYRLACRAKDPFKAEIRNLLIDSAFGGFWAAMMAFNALPAIVILSMMSMNNIASAGN
ALFVKGLAIQLAAAALTGALLGFPFHPHSTPLQIYLCLPMIYLYPTLLGLVTYRTAKRLA
EKKTGAATHQHPRWADRLVQPPPLGASAASPVRQLPPLPGQRHADPDGYRSFQNHQRYFR
PCAGG
>A0A1E3A9F0|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MRSSRLIYALGAILSVVCVLLFRFFEEKQAGTSAGWFYGFWSGILLETAVLGTLMQPHGN
AVTFCVTLITLGALLLDRPGRIFILMASASILCCLFSFLSKEISLALMDLINITISLIIG
IFVASYTSASRINDLLAKGRILKQRDKDPLTNLRNRKAAQKYITDYLERNSDLCAMLIMD
IDHFKTVNDVFGHMYGDKIIRETGTKLNQIFRSSDCICRLGGDEFMIFMTKLPDKDIVLK
KAAQLNKSIFTCLNKDHRKYMISASIGICFTDSVKSTYSQLYKNADSALYSSKQNGRNQY
SVYRNELKDTSIS
>A0A1E3A9D3|diguanylate cyclase|EC 2.7.7.65|Eisenbergiella tayi|TrEMBL
MSNYVGIGENMQYKRFPLWEKGCLAAIIILILAALLPARSLEAKEDRPVVRVGYPIQQGL
TEIDENGNYTGYIYDYLQEIAQYTGWDYEFVRAEGDINESLMTLMEMLENGEIDIMGGML
YNSRMEEMYDYASNSCGIVYTVLKVLYEDTAFNEASREERPLRVAMIDGAAQRREELEEY
CRMNMLIPEIVPCDTEEEMLQALKENRADVMLSTSMEFMEGLRTVARFSPRPFYFVSTKG
KTDLLNQLDKALQSIEQADPYFSASLYEQYFNPPNTELWLTSEEKKYVETAGTLKVGVLS
DLPPYQYTDEVTGQLKGIGVDLLEKIQEQTGLSFQLVVAPDEKTLNRMAAEGSIDLVAGM
NYDYELAKDRNVAMSRPYITTQYMLLISDRMQNRRLEEMSMAMVDGCGCYWEKTDTGVYF
QSREDIVRAINSGKPYYSYMDAYVAQYYFNKTEFKSLKLIPQISIDSSTCIGVVKPASTE
LLSILNKVIQALPQDEMQSIIYANTIFKESPTLADYIKENPFQAAAAAGVVIFLIIAALA
WGIFTKEKLNRKITLELAKHREIYGLVNDYFFEYDIKKDIFTISMKPDGNGEERTAIYNL
KSGTDEKTDYRKQLLEIMVPGKDGIRELQLPEYKQNQTEDTLTLIWIRLAMKTIYDYKGN
PVCIIGKMNDIEEERRERDKLKNQAERDGLTHAYNAKTSLRLIEERLQGLEEGNRGALLL
IDIDKFKNINDTYGHMAGDQVLCEVAAVLRECFREEDIVGRPGGDEFVVYMDRMKENKAL
ADTCERLLQNIRKINVANAGKVTISVGAVVTKRGDRYDEVYKLADNALYRAKREGRDGFF
IA
>A0A6N3QGG3|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CDC 796-83|TrEMBL
MLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINM
DITEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGV
PLLTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSN
IGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVF
IDLDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNIESAR
FIATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRG
RVTVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWS
CEGEIIDEQKFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSAT
LVNDLLEQLGNSPLPPRLLHLIIPAEAILDHAESVQKLRLVGCRIVLSQVGRDLQIFNSL
KANMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIG
VDLIYGDVIADAQPLDLLVNSSYFAIN
>A0A5H8HBS8|diguanylate cyclase|EC 2.7.7.65|Salmonella blockley|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQSYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8J8B1H9|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MKSEMQKIEKRIVVKCVIATLCVVLIFTLSIAQSKYMEQKINETSQSYLSVFSLQSASII
NHQINEKFKDLDVLSHTIEKLELRSEEIAKIITEQKNQDFLEYNIILKNGDLVMPEKTIL
NEEARASILSANNSYIQNLFSGEAFAAADNSRKMGKDTIFVYGVPIYKNDNVEGVLVAYY
SGSFFRNLAWPKNLDDQNHTLLADANGNPVFVPGKLSGSKEYDNALARIAEGWNLEGQAG
EQLKKDILGGKDGVLRYTSGSEDLYVSYHPLGINQWFLITLIPAQTVKVQFHAIYGDLIP
SLIYLVIILGTMGMYFSYIRSQNVKRLEYRLKQQSVNDESYRMIMEQSNDIIFEYDTVAK
TYYHTSNFKKTFGYEPRKRGFLGFLERDYIHPDDLLRLVEMYESMKEQKHLCETEVRIVR
ADGEYIWVHIYLTGIFDNDSRLVRVIGKIEDINDKKMEMERFKELAVMDSATGVYNKQTT
EDMINLYLKGEGRNGTHAIFIIDIDDFKLINDDHGHRQGDFIISEMGTAINRIFRSTDIK
GRIGGDEFMVLVKDIESLDFITNKAKAVCEIFKDKDIGGNKQISVSASIGIAIYDKDGTT
YEELYEAADRALYTCKNVRKGTFSFCGPKELMKVSSR
>A0A8J8B1T1|diguanylate cyclase|EC 2.7.7.65|Sinanaerobacter chloroacetimidivorans|TrEMBL
MNLFSAISIIASVVYLYIGFYGFQLEKRNRIHILFLLFCLGMAVWSFAYAFVYLDDEQKY
IWMKISALGWCTFSSFVLHLVLVFTENKLSKNLLPQIALYVPSAVFFYISVVLYQGGTMP
SRAVEKFFYVGDFVYHSAFLLTSIVLMLIWGLRSNQIRKRKQAKIIVAASLTPFTLNLIT
QTLLPAIGINFFPRMGQIYTLILIFAVYYAMIKYRLFAINPKVLVEELLQEMMDLVILVS
PEGRIVQVNDSAERLLGYSKSELKDQPLSCLLDTETTEEILKYHQKSGIHRFYEKSCRKK
TEGQVPVNLSCSFLIDPVIKDTLGIIILGQDISLLKKLEQEIKEHKMAEEYILFMADHDS
LTGLPNRKHYYQALRRFLEKGAETKTQFAVLFLDLDNLKEINDTYGHEAGDILLRKVGNR
MKASITEKDLAARIGGDEFTLLLADIQNKEEATLAADKLLERINQPITIYGNTVSVSASI
GISIYPEDGENADLLVKKADHQMYIAKKQKKNMTAESPDRKFAFRSIR
>A0A1V6IGE4|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.Bin024|TrEMBL
MDWVEKLKHKYNVDVLYDVFLRENDSLFFLIEESHDICDKPLIKLFGTCEGVGLPYCVDT
IDELLSHIDVKSQICDIRGANEYRDELHREINSDQTKFVLYLPLDFKGTKRYLQLEIIKM
FKRNISIVMLNQIDIKKVNVETLFFESYKDSLTNLFNFSTLLMHIDKTEDSHYFGFLDLD
YFKVVNDTYGHKVGDEILAKVGWKLIEIADETVIMYRKSGDEFIFMTLGLDLNETKKLVK
RIQKAIRSVELPDIKIDCSIGVAEYRHNNGFYDAEDAVNIADVAMYVSKSTGRGRVTYFN
EEQARKVMAFGPLEKTLELLESRAR
>A0A0F7KWE4|diguanylate cyclase|EC 2.7.7.65|Croceibacterium atlanticum|TrEMBL
MAATAPDEHLAVAPTCHAYSGEDVSMGEADRLNWICDNDSWQDGAAVSWLRFTDWDRRDP
PRVFASRITKFTSIAIAARDGDGTMRTFEYRMAEAKPIVAGGVFTLALPPQRADTEAYLV
RILRPHSVTIASDARLSRNPQEVAGTISAVLILVLVLGMLFTPLLFDINFYFILRERFVL
LHAAMILAMMAFILFSGGLITFFHPVPIGVMALLGPLCWPVGAGLAGFFMNAYLEAEALP
PIYRRIVKLTAWWVILVPGFCALKFDFAQPFGNQLYFLAFLPIVPVYAGAIIIALWRRSR
AARFLAVAWLPVIAAGTERYFRGIGLYSGNDAIDDLLVLALGLEVIIIALGVADRFVGIR
RERDQALGEAKTLSEISERDVLTGLLNRRALHDRFESLRREGFVNLALFDLDRFKDINDR
FGHHTGDKVLRAAAVALVGDSDSRVFRIGGEEFLVLFRGGNIRERAENARRAIAPRVSGH
VPGLDRIVTASVGMVEMPFDSISKSGFAELYEHADRLLYAAKAGGRNRLVSEKVQVFRQR
KESAEASAA
>A0A098GH33|diguanylate cyclase|EC 2.7.7.65|Tatlockia micdadei|TrEMBL
MSDELRIIIIDDNPAIHQDFRKVLTDNENSQVFDQLDEELFGKNNSANHGNLLPYFEIDT
AEQGREGVEKIKNALEQGRPYALAFVDIRMPPGWDGLETIMRIWQIDKDIQIVICTAYSD
YSWEETVQKLGVSDNLLILKKPFDKIAVRQLACALTRKWLLAKESKNHTLSLQQIVNERT
ESLQHSLSLLRATIESSSNGILVVDLSGKIVDYNQQFINLWDAPKSVLESKDANLLFEFM
LGRLQKSKEYLEKINHLNKHIDDTSLNLLKFKKREKIIECYSQPHRVHTTIVGRVWSFRD
ITERAFLEQKLEHQATHDSLTDLPNRVLLIDRIQQTIASAIRRKEHFAIFFLDLDRFKLI
NDSLSHKVGDELLFAVAKRLSTVLRKEDTLARLGGDEFVMIIPELAKNENVVNVAQKVLT
SFDQPFHVAGREISISTSIGISLYPNDGKKVSTLLKNADLAMYNAKEHGGNQFKFYIPKL
NQELSKRLQQESELRKALANHEFFLLYQPQFDIKKNNLIGVEALLRWRHPQKGIILPLDF
IPVAEESGLIIPIGEWVIHEVCNQLKTWQKNNLPLVRVSINVTTQQLKQVNFATTLEKIL
KQHGVNPKYLEIEITENVIITHVEIQQMIQEIKKIGVKIVLDDFGTGNSSLNYLKKLHFD
RLKIDQSFVQNIAKSRSDEVIIEAIIAMARSFNFKVLAEGVENQKQINFLKEKNCDGIQG
FLFSGPVPPDKITRILDKKAAENRSQLE
>A0A2S6Q4Q7|diguanylate cyclase|EC 2.7.7.65|Proteobacteria bacterium|TrEMBL
GVLIIAGALWSIYVKVYSDKKQKKLAPKAIRELQVLRDTIQTAMVCFNDNEELVAEKLGV
GKRTLKQIMTTEKEVSKNIKNKIIFNHAQNVAGLDHLTGALNKSSFEAKLKDLENTEKAL
VLFIDLDKFKPVNDTYGHKAGDSILEGVAERLMAEFNHPHVVARLGGDEFCLIVYGKDKK
DEEKLVKKVEKLVNEPFIVEDIEDEISVGCSIGSAHYPTEGSCGLELNKVADKRMYEAKL
TNGIER
>A0A857JGS1|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MVPQNRKSDKALLGAFSASSGASARSRLSASSRLSARSRLSTHRLEQLLAKTRYQPETIA
IFKAPLLASMNDIIDEVYREYPQMVGVNLHTDEYNLSTDLRDLLRQYIEGLFVTARYDHA
YITERVELIVQYKNIGVPPLDFIQIINTLSGLLSSLAQQRCALGSAQATFCHFIRQLLQF
DIELCVDTNLTHLYAEVDMLRQQNESLSRDIEARIAKRTKDLMDQVRLDPLTKIYNISAM
QEMLDKELALAKRRKTKVSLVYFDVDHFKKINDTEGHIKGDEVLKEIGQTLRQCVRQTDI
ACRYGGDEFCLVLLECNAQEAQRVCEKLIDTFRGRYPTYSFSMGIAETGASEFVSVKQLI
HLADQKMYLAKKEAGFTIVI
>A0A7H4SK46|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MAAATLTQDINIVNITHDKIQHLYYIYSVISILLIAMCITLGLLMLRQNNNLRRAHVRMK
TLANDLQASKEKLQVQNRRLQYDAYHDSLTGMPNRLSFWQRLQEIVNQVRPYQGCAVVML
FDLDSFKDVNDTLGHDAGDKLLQDLASRLSFFRKTSETLYRLGGDEFAMLSYDLTEEMAL
ERANVIREKISQPYQIYDAQINIDACIGDRYL
>A0A857JMS6|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MQIVPKPAANQAFAYKNASIKSNLTLVWYFSIVALIGFGVHLIHHLRLGSGAFSPDMLPY
LAVYLSNVLYALLNLLLLPSARVSNSASWSVSLLEMMYPAFLAFMATVLSIYTSMQGHGP
VPFIMGMMVIAMLVQGHLLFLFGLLFCCWLAVSAGLLYMLPSGQASSPILTCFTTMLIAF
FIARLAEKNRVGQFTVLQELHDKNQLLEELAVQDPLTKLYNRRYFTNKLEIETARSLRYQ
HPLSLLIVDVDDFKQINDNDGHLVGDEVLVEIANLITQQMRADDVVCRYGGDEFVILLVE
ACAEQSKEIANRICESIERCSFRRASAKVTVSIGYAQYIGQPLGDFMQQADQMMYMSKKR
GKNQVAFFGCDFETESAPETIE
>A0A857JS25|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MNTKQTKGIEIENPSKYMTLTYAVSLTIIALLSGAVHLMLDQVIEQQSQTGKIVNISGQQ
RMLSQRAGLFVLHHLQTGSHDSKLVALDAVDKMLINQNFLLQRHKENQHADFSAELNALY
FNPPDNVQQNVIKFADTIKGILTSPNELNAANLDKQKQYVVDVAKTSLLESLHSVVEQYE
KESLEKVDELRFAQNVVFWIIIFTILIEAIFIFRPMVAKVTLFASKLQREANYDALSGIF
NRRAFNLQSAQQFNVSRENDQPLSVLMCDVDFFKNVNDTYGHSTGDEVIKRVAQVMLENT
RNSDVVARYGGEEFIALLPRTSKHEASIVAEKIRRSIEGIEINIDNHQLRFTISVGISDL
KPSDTDIANVILRADEALYNAKESGRNQVILSA
>A0A857JID2|diguanylate cyclase|EC 2.7.7.65|Paraglaciecola mesophila|TrEMBL
MFIVSRFIRNYLNTGTKASNSPAVRQQIQVTNLFGFIGYFITFILGVTALFRSQWDHNDD
FYLGVTLLIASVLFFTSRIILKYFQSKNGYKFSANLVTSALMLLMLYLIVMGGVKNTGPL
WIYIVPPVVLFFGGLKRGLVQLGAFALVVIIILEFPNNGLLFAEYSAEFRSRLIYSFLTV
SMLFVFYEYSRQRSFKTLQELSKKFEQQARIDSLSGLQNRRGMLEKLEYEHHRILRHSKN
MTLMMCDIDHFKQVNDQYGHDVGDIVIKQVGQMFANGLRKQDTVARWGGEEFLFMLPETT
QQQAFVLAEKLRKKVENYEQKVDSAHLSVTVSIGIYQMHPQDKLDHAISRADTNLYRAKT
HGRNCTVVTD
>A0A2N5ABS3|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
EEAYVANQRNNLANVAHEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQ
RHQEAWRVALPHRRTLPVFGVSGSVVGNNPILLKDDPLAADELMATLELGYLLNLTQHDR
DFAERMQYISRSGFFTSTLPLRDESQVMTHYSQAISALWFTRQSQRNNPGRGVIWQTFPD
DDPQLEEQVVTASIPLDFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNL
LASSAPGNVLTLLSPREQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLRE
GVRGNFGTITIALTLMWVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNR
GALFEQAMAVASACQRSGRPLAVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVRE
GDLLGRVGGEEFCVVLPNTTLQDAVAVAERLRQRIQGREVFLHNNV
>A0A7H4MCK9|diguanylate cyclase|EC 2.7.7.65|Klebsiella variicola|TrEMBL
MNEESQKYIAVIFKEWLPLYDSLTPDVRALLKKMADERSSMLATRFYDFIFQDPDIARHL
SYELVEERLSRSLAGWVQQILTCEKEDLQALAERQYQIGSIHSRIGIPAEAVLRGARQIK
SGLVEAIRDSQVARDTGIAAIHYAIMAMNMAVEMMCHAYTLSHYRATKNEEAFRLYSLMD
NVPMEYGKQQASLSGWENSAIFNIVSENRTDLNATLLSESEFGLWFRHKCVRYFNHNPQM
GEITELIGQVGCADYRMAHRGTGCWL
>A0A5C6CS86|diguanylate cyclase|EC 2.7.7.65|Bythopirellula polymerisocia|TrEMBL
MSDTTAIDTEPQEQSNIAQSQEKSTRLVSTESRVAEISSLLRALEDVAGGNGLGQRREEA
KSHPTVRHENKLVQVRLGMASGLFTALRQKHPQTAEHSLRVALGCSSWSLYAGLDEETRD
TIEVAALLHDIGKIGVPDSILSKPSRLSSEEEALVREQCRQGSDIVAECCGSERVLEAIF
HSTTRFDGGEKDQPIRGEGIPLVARMIAIVDAFDSMTTDQVYRSAWSRDRALQELFEYSG
SQFDPQLVKQFQEVLSEHHDVLTERVAARWLNELRNSHDELPWQPAHESDTPGSASRMAA
SDILARPLFEQKLIEAIRDGVVFVDVQAKITLWNKGAEQLTGISRGAATGRTFAPSLLEM
CGHGKRRIHDGSCPVARVLRTSSQIRQRLMILGRQGKLVPIDLHAIPVVSRDGAILGATI
LLHDAQSEASLEEKCEALHAEVTRDPLTKVANRAEFDRMQALFIEAHEQAQHPCSLIMID
IDHFKSINDTYGHQAGDEAIISVAGLLTSMCRTGDLVARYGGEEFAVLCADCNNAHASRR
AEEIRKKLEETPHSHLGDRRITASFGVTELQAGDNSETMLRRADRALLMAKEQGRNQVVQ
LGNGMEQQKSKKKWWWLGRFSGKPVIETSLSTAVPIDIAIAKLRGFVSDHQAKIVSTKDN
KVELEIASSKVSFDRRKGDRNIDFRIEMEFSERREQRMNNLGFAAGEYTSTNIEVKVCPR
RTSKRRGSDVADRAALILQSVKAYLMAKEECELLAESQLLVL
>A0A6G7GT31|diguanylate cyclase|EC 2.7.7.65|Kuenenia stuttgartiensis|TrEMBL
MQKTLKTLEESCNYYKNLYNTSPIGYVSLDSNGLIREINQTGAKLLGVEQNKLTNTSFLD
FVTAETSDIFLNHLKQCEHSIEQVISEIIISAKGHHRTTLQLISIKNKDENGCTIYRTAI
VNTSGGLQQSISGRDKPFVDYENATTEALAKENKRLREELSGHLRAEEDLRKLSRAIEQS
PCTVVITNAKGIIEYVNPKFTQLTGYAPEEVVGKNPNILKPDNILAEEFDHLWKTITSGK
EWQGKFRNKKKNGDLYWEYAYISPVKNQSDSITHFIAVKEDITERLKAEEELSKFSRAIE
QSPVITIITNSRGIIEYVNPRFTESSGYTAKEVIGKNPRVLKPENISSEEFAELWKTLLS
GKELNGEFCCKKKNGEMYWENVYLSPIRNHEGKITHFIVVKEDITERKLMEEERIRHIKE
LEDLMSFSTIINEEDVQEEALFKHLVSALQKNFAPDIAAAIMLDKEKNMLYLPVIDPVMH
AGELIHKEAILDPSLCKVMNTGKKSIVNDITTESPCECIVTHGKRGGYVCFPIIIGNKTA
GMVLMMKKEFSTWKNKKTQRLMSNYTETAALALHKLELLEIAKHTNVMDEFQGIYNKRYF
TELLTKQLAVAKRRDENLSLLILGPDNHKATTETYGSNNAGNLLLQQIAGVLSDSVSNSD
IIARYDKAEFAIIMPATFATRALVKADGIRQRVEYTGFHDPASGNQVNITISIGISSFPE
HASEVEPLVTLANKAFYKAKNDGGNRVEAIVTSR
>A0A379IPS3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MGDGNYNDHKDVGAGHCEGLRESGKRTLMRTILLATGLTLGGFSILQALAGNYPFAIIEL
LFTALLLFGAWRIERARHLYLWIYLYLIPTFCFILYIIVMPDASSAAFVWLYMIPLLAYL
LLGKRRAFLLTAPFMLAGLLLYFADNHLNLDTRGLIDVGNAALCGVLILVFVHIYDGLRM
QAYEELERLAQTDSLTGVASRGSFQHALQRSIQEAERSSGHLVLVLLDVDHFKQVNDQWG
HEAGDMALQHICQILQHRLRVTDFLGRLGGEEFGLLLRHTDSAGADPLVEKLRKQIADQP
LEYDGAQIALSATFGLAAWPRDGRSAAELYRTADRRLYSGKQRGRNQLVSADLPAELLLD
KFDVRF
>W9UZU0|diguanylate cyclase|EC 2.7.7.65|Nitrincola nitratireducens|TrEMBL
MKAKRMIRLLDNADAAVLLLKQDKEQGSNLSFRDLPSPYRKQVLNWAINQDSEYLELESH
RFQRLRDKRHQMILGHSGDRHHLQRTLLLKLLPELQKGGEPYNATASVLGPLLGWDNCVV
AKRVSAKELDILGFWSHGNLKSPQHHSLAGNAAQNLYEGLHRLHQSAICREFPLDSMISQ
TPSALWIGHRIDLPDNHGTGHICAWGKPDLLDTDTSEWLIALAADTLGAWLLTQSSTGEK
NYEHSTEPRDLLTSLPGRKTFDLALQHAVEAYKQRQQDCLIALVDIHGFSEINNTYGRQE
GDNLLKRLADELLEMSRRKDQVFRFGGDEFMLLMPLTKGRPPVAKRLKAIESNLQENHPE
FKLSYSMATLSDVNGSAEDLMLKIDQELNNFKHNYKLN
>A0A448CEE3|diguanylate cyclase|EC 2.7.7.65|Achromobacter spanius|TrEMBL
MRINLRGLVLALTVLSAVAATANALYASYLVQRDQLIANTLESNRVYAAKLAESTTSFLK
SAQQQLAYSARHLASQVDAPDVLAGEVSRLREQANDFNSVGVISADGIILATSQTFSSFV
GARVDSPGSRAALQARRPLISKPYVSMAGNMLINLSHPIYSNDGRYLGYIAGTIYLRSHN
SALQELLGKHHYQDGSYLYVVDRDGQMIYHMQADRVGEDVNRNPVVAAVTRGESGAQRVV
NTQGVDMLAGYAVEPLSGWGIIAQRPAEVTLEPIHELIWALIGYAAPLALAFLLAIWWCA
RMISLPLSQLATNVEHQDVAVAMQRVQSVKAWYFEAERLKRAVMNSISSLQDKIGKLNQA
SMTDPLTGLRNRRGTQDAVEQWQTGGTPFAVVALDIDHFKRVNDTHGHPKGDEVIRGMAK
LMQECSRPSDVLCRSGGEEFLMLLPNVGMKEAARVAERLRLHTADRPLHGVPGITVSAGV
AQWPSCGAEVDQVFQAADAALYAAKAQGRNRVVVHNNA
>A0A7L6UEZ8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C17|TrEMBL
MNDENFYKQAVDLDETALSSQQNDHQRSGLRFARRVRVPRAVALGGMFFPVAAALVANPV
PGVWWLLLVGWAFVWPHLAWQIASRAVDPMSREFANLKTDAVLAGMWMGLMGVNALPTAA
LLMIICMNLMGAGGVRLFVTGLALMVVACLVTLQLTGTSLALRSAPLEGVLTLPVIVIYP
LLFSWISYQAATRLAQHKRRLQVMSTCDGMTGVYNRRHWEILLRNEFEHCRRQHREATLL
IIDIDHFKSINDTWGHDVGDEAILALTQQLRITLRGSDVIGRFGGDEFAVIMCGTPAESA
IAAMSRIHEGLRGLRLACAPQVILHISVGVAPLTPQFSHYREWLKSADLALYKAKNAGRN
RTEVAA
>A0A2H6JDG8|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin12|TrEMBL
MLCSRAGERRGGDRRRARDRRGMPDANAGVRIPGWPEQRVQFLTRYLFVALGLLFFNRID
RAEPAWLTLTDLNLVFLAYTVFNTAMFLHAHRVLHAPLRYRAAMWMDIAMVTVAVLNDPY
AIPPSVLVFIMIVLGNGMRYGMRLFGEAVVGCFAGAMVALSLRHAGALDEISAGVVFLNL
FGAIILVYAYFLMGRVESSRRLLERSSREDNLTRLLNRRALDEVSRPWFLEVVGGGRRLA
VMFADLDDFKSVNDTLGHTYGDRVLIELARIMRDSIRGTDLAARYGGDEFVLILPDLPLR
GAGRIARRIREGFGAWAAGEGINCNVTIGIGEAPTHGTNLDAMLDSVDRAMYAAKAGNGA
DGGVCYAGAPERGAGDGRVVS
>A0A379J0K3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas mendocina|TrEMBL
MAPGWSPSPPVLVTLLVCFGVILLAHWMTRQRDFPGRDSFILLHLSSLWWMACASLELSV
MSAECKMFLSGLAWLGILFTPTFWAVFLWQYVNSVRTPVPRAGVLALSLMPVLVWIIALS
NPWHNLFYLASTGPIDDSPGAPVRYRHGPLFYATAAYVYLLMAFCMGVVVRAAVLSHGLH
RRHYLGFVLVTAAPWTANIAYVVFGWTVFGVDPTPFCFAFTLVAFAWLILGVRLFDLLPV
ARHLLLEALIDPVLVVDPRGRVIEANPAALKLAGLQQGWQGRALVDWPVFGADLQRLLEQ
HRGEASEQMLSLTSAARYYEVRVRGIERATRNGPVLLGRMLYVRDVTLRHLAELKLAEAL
AVSEERLRTISVLHEQLREQALCDPLTGLYNRRYLDEFFDRELARAQRESLPLALALIDL
DHFKRLNDECGHLVGDDVLKAVAQHLLDNLRSTDAVFRIGGEEFLLILPGLDAQAAEVRL
ESLRLQLADMDQPTRIGALPVTLSAGIAVWPTNGEKLDELLQAADMALYSAKRGGRNRIA
LAS
>A0A6N2XQQ1|diguanylate cyclase|EC 2.7.7.65|Enterocloster bolteae|TrEMBL
MIETKEIMSREAVTGGIFECRYDESLTLTQADNSLFRLLGMNAGSLTSGTPISFLDRICA
EDRPIFLEKIRYQLSRSRVFMSELHIMTSNGQLRWIHICGELLTEQESPLLHCIFHDVTD
ARDRQERLAIESQIYDIILSQTQDIIFELDCLTRDIYYSPTFEKKFGYQIPVRGFPDSMF
ATDIIHEKDKIPLRSCFQSILAGQDQMQCEYRLKHRNGRYLWVSVNATAIRDLRGRLLKI
VGIISDINEQKEEILRAKKDALLDPLTSLLNRRECIRRIEAYTRTEEEMGALILIDIDNF
KSINDTNGHLFGDKVLVDLAAALRLAFRRNDITARIGGDEFIAFMPHIHVHGDVVPKLET
ILYSLSRCAKTGGKEETAPEPDDAVTFSIGVSFYPDHGKDFSSLFEKADAAMYHAKRRGK
NQYYIYKEDAPQAYDS
>A0A1W1I0T6|diguanylate cyclase|EC 2.7.7.65|Nitrospira japonica|TrEMBL
MSDTPLPSQYDPRVLLNSQPLIITVIDPLTHTVIFQNDSSRKKFGDISNATCHEKIAGCS
TPCSFCRMPETVETGRPSSNEVPLPNDEHLLVQWAKVETTTGATHIVETITDITSLKRQQ
QETERLVTKLSATNRDLIQANQLLQDQSVRDSLTGLYNHSHFEQTLVHLCALALRSMRPL
SLLFVDLDNFKQINDMYGHTTGDQVLREIGWLLDSQQGPSRGIARASDFAARYGGEEFAL
ILPDTSMDGALSAAERLRHRVTTLTMLPELSALTMPSFALTCSVGVASFPIHADNPTDLV
NAADTAVYAAKRAGKNRVRMAAPAPPPPSVPGPLVRS
>A0A373BGD6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. SWAC57|TrEMBL
MNDECMAKLAEQWGKICQHYSVNDHIKAQNFIQQHSFVLVNEFYRNIVLEPEAADFFKDD
IIQQRLKNSLNQWLIESFDVALNQAYFTAVEKQQKVGQVHARVGIPSWLIMRGIREIEIK
ILQLLDELQLKNSHQMLSYMLQIMGFATEIMCRSYEANTEQSHEVKHSYRLFSAMQDVAV
QKDKQRSILLDWENELMFKVFSEHPQLQHIALSKSEFGLWFVHKAAYAFTGAEQVETIIG
LIQQVDALNLHVLDCQDQTQKIERIQDIREMNRQIQHLVDQLFQVTEYIDSGNDSLTQLL
NRRYLSTIVSREINFARRNDAPLSLLAIDADYFKGINDKYGHTAGDLALRFIAEALLDVA
KGSDYAFRVGGEEFLLLLVDSNLQRASDVAETIRSRIQETSIRTPLGQSFSFTVSIGCTI
YNGHPDYQRFLDTADAALYTAKNNGRNCIHVSEKLLSV
>A0A2H6JBE6|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Bbin12|TrEMBL
MSRTPDPPRAAGSGLPPGLPLKISGIVFWGSLLVGLAMALASLHGLQEHLAWEYRASADS
FAYRMQGFLGAHPDALFPAVRREARRLRAELGLRGVDLKLGDRQVRLGSTGAGLKPRTRQ
VRDPATGRVLQIRVYEPDLQRVVTATRKRMLIVGALSFLLLGMILKWILERVLSRPFLRM
VETARRFSRGETNLRLDERRNDEFGFLARFINRALDYVLTQQEELREALARVRRSEAALF
REKERAEVTLHSIGDAVITTDGEGRIDYLNPVALRLTGWRAEEIGGRPIASLMRIVGEHS
GEEIPHPVVQALCENRIVELPPHSVLLCADGHSFPIADSAAPIHDRRGRTIGAVMVFHDV
TYARRLERELSYHASHDALTGLCNRRQFELVLEQALQDAVSGGREHALCYLDLDQFKVVN
DTCGHGAGDELLRQLAARLSAKVRESDMLARLGGDEFGVLLYGCTPRRAYAIAEELRNVI
REFRFSRREHRFQVGASIGVVAINSGSGSVAELLSAADVACYAAKERGRNRVHVYQTDDH
ELQERRGEMRLVSRINRALQEGRFRLFVQDTAGLSDDARPGYRELLVRLVDRDGGLLLPM
SFIPAAERYGLMPSVDRWVVANACRLLVEESARDSEGIWAINLSGQSVCDEAFLEYVMHT
VRESGVAPQRLCFEITETATITNLGHATRFMNVMHGMGCRFALDDFGSGLSSFCYLKQLP
VDYLKIDGAFVRDMAEDPIDYAMVEAINRIGHVMGIRTIAEFVEDEAALNALRGLGVDYA
QGYWIAEPHPMAADDAVAATRVPGRC
>E2X849|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae 1617|TrEMBL
MRLTTKFSAFVTLLTGLTIFVTFLGCSLSFYNAIQYKFSHRVQAVATAIDTHLVSNDFSA
LRPQITELMVSADIVRVDLLHGDKQVYTLARNGSYRPVGTSDLFRELSIPLIKHPGMSLR
LVYQDPMGNYFHSLMTTAPLTGAIGFIILMLFLAVRWLQRQLAGQELLETRATRILNGER
GSNVLGTIYEWPPTTSSALDTLLREIQNAREQHSRLDTLIRSYAAQDVKTGLNNRLFFDN
QLATLLEDQEKVGTHGIVMMIRLPDFNMLSDTWGHSQVEEQFFTLTNLLSTFMMRYPGAL
LARYHRSDFAALLPHRTLKEAESIAGQLIKAVDTLPNNKMLDRDDMIHIGICAWRSGQDT
EQVMEHAESATRNAGLQGGNSWAIYDDSLPEKGRGNVRWRTLIEQMLSRGGPRLYQKPAV
TREGQVHHRELMCRIFDGNEEVSSAEYMPMVLQFGLSEEYDRLQISRLIPLLRYWPEENL
AIQVTVESLIRPRFQRWLRDTLMQCEKSQRKRIIIELAEADVGQHISRLQPVIRLVNALG
VRVAVNQAGLTLVSTSWIKELNVELLKLHPGLVRNIEKRTENQLLVQSLVEACSGTSTQV
YATGVRSRSGWQTLIQRGVTGGQGDFFASSQPLDTNVKKYSQRYSV
>A0A2G4AX13|diguanylate cyclase|EC 2.7.7.65|Vibrio splendidus|TrEMBL
MSIQLDLTTTTPCQNFDSAQGRMTLQNHRIIDVDNEIAQIFGYRTREKLLLNVEFVYALV
PDSYQELAKKRYLEAIKGKLKKGKLYTDIPANGRNISIFCLSHIIELNSKPALQVTIIDI
TSVVEAQRKRNETDRMYRKLLNTSKQGILIHRNFKPLMVNQAWVEQQGADSIEQVLAMDS
ILSIVPEDQRSTAIRRCENILNGNTPNFSSVVSNQCFDGTHKYFNLYDNVINWEGEDAIQ
VILEEVTDKVLLERELLHRAMHDDLTHVFNRRAIYDWLKKPVNQHMAMSCLLIDIDDFKS
INDRFGHTVGDTVIRHLADTIKTHIELLGGVVGRWGGEEFIVFIPKAKSTHTKIISERIC
HTFNQHTFYGINRRAFTASVSIGVTNQCLSHSANTIDTLIRVTDDALYRAKANGKNQVSI
NDDVVYYEALA
>A0A143QL52|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians|TrEMBL
MNSLREWWALPVDYGWNVAFARSQQALEITKILIGHWCWLFGAAAAIGLVVPGLAEGTLG
TAALWFTVATTIPVGVAWWVGGWPSWQMSIAFVFYADVVLAAVVLTIGVPTTVLPTAALF
TVIGSYVVGFHGPKLLTAHYGFALVTTAVLYGSALVAEPELRLLATVYLVILILVMFSAP
LIVHTFMMMLRRDATGAFYDPLTGLQNRRGFDAAIGNLRLRPGSANGMTAVVMDIDNFKA
VNDRYGHLQGDAVIRLAASRILDVFPAPAITVRLGGEEFAIIALDDRDSVVASAEVLRIR
LCNATDRSPLTASIGVAHAVVDGREIGTAVEELLGRADRAMYRAKGLGGDRVALSEGEPR
SPRPAGEPH
>A0A5P9CBS0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MPDHFAKNEQHRRLVLKALLWITLVGGLFFFVVNLLRDNWLLATLEIGYAGVSLYMLMII
DRTRNLQLLTTIYLLPFFSIMIVALSRPHTTFAVFAWIQTIPIICYMLLGLRLGLYGSIL
FVGIGLFTFNQRLPAEQQLVNTVILANLGLASLAVMIFAHIYERSRVLNEKRLIEQATTD
ALTGLANRMKLSEVFERERAHALRNDTALSLVFVDIDHFKQINDRFGHEVGDRALAHFAT
VLTQRLRITDLFCRMGGEEFAVLLPGTPPGRAREIAESLRQRLADKPLEVAGSAVPMTLS
AGVASLGSDGQSLDELMRAADRRTYAAKRAGRNQVVADEDEASAIDAVPG
>A0A5P9CD41|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. THAF187a|TrEMBL
MGDGDYNEHRDVGTEHCEGLRESGKRALMRTILLATGLTLGGFAVLQALAGNYPFAILEV
LCTALLLFGASRIGRARHLNLWIYLYLVPTFCFILYIIVMPDASAAAFVWLYMIPLLAYL
LLGKQRAFLLTAPFMLAGLLLYFADNRLNLDTRGLIDLGNAALCGVLILVFVHIYDGLRM
QAHLELERLAQTDSLTGVASRGSFQHALQRSIQEVERSNGHLVLALLDVDHFKQVNDQWG
HEAGDMALQHICQILQHRLRVTDFLGRLGGEEFGLLLRHTDSAGAEPLVELLREQVAEQP
LEYDGQLIALSATFGLAAWPADGRSAAELYRSADRRLYRGKQRGRNQLVSADVPGELLLD
KFDVRL
>A0A550AGZ7|diguanylate cyclase|EC 2.7.7.65|Shewanella eurypsychrophilus|TrEMBL
MKTNSFSVLILFWLAFLTSFSSFAEFEARLINTTDIVIQDTDIWRKINNEPDSPPASLEA
LKHLYRSSAPIKNSLVNQSGAYVARLKLNNQTNVHASWFVRINANFVDQGLGFWESVQFL
NTGVINFSQHGDINTPKLMHTQAFGLPLSQQESGYLWLYIDAEHYALPLSIDIINSTSFY
HKQFITNAVTLFSIATMLTLAAIALILYLKTRLTVTLACSAYIGLHGLGWAAASGLIDDM
FNIQSINTSYLGIMIFPFAIASASQFTKLLFNFDSLHKRLAKLFNGLSIICLIAGLILPL
LSFSISFAISHIIALIWVPLAIVIGVKMLIYSDFRAKYYLLGNLLYGLSMFYYILSHSDL
LTGQQHAELIVMLALTGDCFCILLSLAAWLQQKKQDYSHTYYQARIDPLTHIGNRYALSE
ALTQVDDKYIITFIDYDGIKQVNDKLGHNQGDALLRYGAKTMANALDSKGEVFRTGGDEF
VWLLNSQSFSNLPSAVEEIEQMMAQCQNALQSKWPQSGISYGIAHAQESSNQSECLALAD
ERMYQHKRSKYQHPVAEDV
>A0A174IC72|diguanylate cyclase|EC 2.7.7.65|Hungatella hathewayi|TrEMBL
MEKNRELLKTNLLVSVILVCGFLVTAFFSYQANYEASLNNIEQVASLTTEGIYYQLTALF
TRPVNISLTMAHDSLLAAHLEGEAAHLEDEQYAWTIKNYLETYREKYDFDSVFLVSALTN
RYYNFNGIDRILTEGDPENVWYFDMLNDDLEYSMNVDNDEVNEADNAITVFVNCKIYGPD
RDFLGVVGVGMRVSYLKEFLKSYEEKYHLNACLIDENGVIEISSEHTGYSRIDWFQTFEQ
EGIRSQVLGWKEDSANLELWSDTAVGGQGRSYVVSRYIPELSWHLVVEQNNGAIVSEIKD
RLYQTGIIIIAIIITVLVVITTVLRNFNRQITQLMEERQDAFKRATEQLYDNIYELNITR
NRYANKLTEQYFGSLGAGDLPYDQGLKVIAEKQIKEEYREGYVSTFTPENVIRQYEMGNN
HLRYDFKITQDGSRYFWMRIDAYIFFSQEDECIHMFTYRKNINAEKEKEIRASFDEMTGF
LTKMETGREITALLSRPAEGVYAFFLFDIDNFKQANDSCGHAFGDYGIREFTSIIRKHFR
VNDVLGRVGGDEFAAFIPAPDSEWVEDKAKELSNALRVTCTEGGKSWEMSASIGVSIAPI
DGNDFDTLYQKADAALYQTKQRGKNGYTIA
>A0A165LD13|diguanylate cyclase|EC 2.7.7.65|Rhodococcus fascians D188|TrEMBL
MPSFPHVPHPSSVHGTAGLRTRLLMYFLLATTGLYAVGVILTLLPHGDRVTSDVTGGVVA
VGLGAAGVVMLWVRPGTAVALRLALAAAMVATPAVMAFHRLAAAQSQCLIAAMFLAMYIR
AFHRDGPGRVLVGVLVVSVLSAVWVSPAPMYPISYLIFGVAVIAAGEAFGVVTKALIVAS
CTDPLTGVFNRAGWEMAAAEVAGNRTAELPVAVVIVDVDNFKAVNDSGGHRAGDELLIDL
AQSWTRAAPSDAVIARLGGDEFAALLTGHSRDVVDEFARITAESLPYASVGTAQSTDPQE
SVSDILARADENLYGVKHVRRERP
>A0A649YZI5|diguanylate cyclase|EC 2.7.7.65|Vibrio sp. THAF191d|TrEMBL
MLRVFATMCMLLFLTSFASASNKQTLIVTNSKAWKPFSYINEEGEPAGILVDYWNEYGLK
NNQNIEFLLLDWNDSLEAVRSGRADVHSGLLWSETRESFLDYNAPIMSIDTQLYISSRLM
GSDVSLFLRGEHDHLVGVVKGAYEEEFTRLHFPNLNIISFRNNERMIDAAFAGEIDAFVA
DLQVANFYLHTTKGLNKFIGIRHLYSGNLRPAVSEGNLALQNHLSHGLKLISNEDKQRIL
GRWMYINTVYPDYLLPLAILMILLAGVAYIFILRFSVNAKTRELAKANQELRVLSETDPL
TELSNRRHFVEEFQQRLVVPESIAVMIFDIDDFKVINDNFGHEVGDTVIRQVADAVRTVI
KKDHLFGRIGGEEFALVVSGHSLGQVTTIAHKVCHSVRSVVIEDKAISVSLGCAYYPLTS
FNITLSDADHLMYQAKSLGKDRAVIQQIILEELSEQKAVNYE
>A0A6M8MMK9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas graminis|TrEMBL
MNDRIDFKELHWLLTVTQNIDVGVVVLDQEYRVQVWNTFMENRSGILSYEAANRSFFSLF
PEINERWLKNKIDSVITLGTPAFTIWEQRPYLIHFKSYQPITGQEDFMYQNTTMYPLRST
TGAVTHVCLVIYDVTDVATNRLQLQAANRELQKLSSTDRLTSLYNRGHWEEALRLEHARH
VRYGSSAALVMFDIDHFKRVNDTFGHQCGDRVIQRVADVVREHIRDADIAGRYGGEEFAV
LLPDTDKQGGAMFAERLRAAVEALDVMQEGEAIHCTISLGVADMTSPMDDYKMLIERADQ
ALYESKKNGRNRVSVDASD
>A0A2N8ZMP0|diguanylate cyclase|EC 2.7.7.65|Vibrio tapetis subsp. tapetis|TrEMBL
MQLTSSSIILTILLVGSVTYWGTLPFVSTESKTSEFHQTNSFNPDDMVEKSPAGELYIKV
NALSLSAPNKAMVLIETIKAHSPLYQQPFYRIHANFTLARIYLNQGKANKSLDITFEVLE
DAKAHNLIWAEAMATKNIATQYTKRGELSKARELLVRSLELSRSINYERLTMANYNVLAI
VNSIQGKRNQALHYYHKGLEIAKNYPDDTTQTHIVTNLGYLYAQSKNWKQALEYTDDAIE
LYNASNIESRDALVVPYITKATAYMNLNDLDNANRYIDASFDILTDISPTRLKMIAYEAL
SKLRFLESRINEAKQATLECLSLPEANNFLLESGRCMRQQAEISVYLGHYEQSLDELQKA
LSYYESVPSEVDIIESIKVLADIHANKGDFGVGYMYLEEYHQRNNELLFGEREFSFNQMQ
EAYQASRKKDEIALLKSEKALSEIREQQDELRIYLFIAIAVLGFGAFLYQKNRSHYFAAM
NQTLTSSNKELSKDALQDTLTGLHNRRFVEAFLENINNETYTSSDDARYSVCLLDLDHFK
KVNDTHGHNVGDEVLIEAGRRLTRLIGDDGMLARWGGEEFLFIIEHKQSDAFVPLLNRIT
DTFSTTQFATSVGPLVITASSGAVTNMPRTLLLANWGETLNLQTNYFTAPSKTDEIN
>I6D137|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MYDVGPYLISSDECIQVKEFEKNYCADIMQVVKYRHVKNTGFISFDGKTFVYYLYPVTHN
RSLIFLLGLERFSLLSKSLAMDSENLMFSLFKNGKPVTGDEYNAKNAIFTVSEAVEHFAY
LPTGLYVFAYKKDVYLRVCTLIIFFAALVAVISGASCLYLVRRVINRGIVEKEAIINNHF
ERVLDDGLFFSAADVKKLYSMYNSAFLDDLTKAMGRKSFDEDLKALPEKGGYLCLFDVDK
FKNINDTFGHLLGDEVLMKEVKILKSQLLVDKGKIYRFGGDEFAVIYTGGTLEELLSILK
EIVHFQVGSINLSTSIGVAHSNECTTVERLKMLADERLYKSKKNGRAQISWQ
>A0A7S6YWX6|diguanylate cyclase|EC 2.7.7.65|Xanthomonas sp. WG16|TrEMBL
MGRGGTQAHTSCVRSTCVRRIGQAWLWLLWCCAVLNAWPAGAQVLKHTAYHTVTRWNMDD
GLPHNLVHAVAQGEDGLLWLGTWEGVARFNGRDFTVYDRQNTPGIELGGVFVVVRDSTGG
MLFGTAFDGVYHYQDGHWQQLGDASARHLAVSALLRRADGALWVGTPQTLYRIEGDGRVV
DVGRQTGLPRARVTALSADESGDLWVGTEVGLYRLPRDGGQAAAWGRVHGMRDAPVRRLA
SDRQGGLLVAGNDGVWWWSRGGGLQRFRQGQRVDSVLLDRRGHLWMSLSSGMLVVHSGPN
DPDEQIAISGVASPALLEDAEGLIWVGSTHGLFRIAEGAAHGVTHDEGLSSDYVRCVLQT
GQGTVWVGNAVGLDRWRDGTISRVSLSPSEGGRVLEQSVLALADAGDGGVWAGTYSEGVV
RLDAQGHVLVRIGAADGLPSMSVRAVLPDGDDLWIGTTAGLVRWRNGKARRYTAADGVPD
GSVQVLYRDAQGIVWIGTDRGVTALSPDGSTRAWLGEQDFPGQNAFDFLRDAAGDVWIAS
DRGLLRLRGDSFRVYDHRVGLPRDKVFRVIDDGRGYFWLSSNHGVFRIARDNFDQLDAGT
REQLSVEVVDRSDGMPSNQGNGSSAPAGWLTRSGQLLFPTAAGLGVIDPARVGTLQGHRV
PIVFERLLVDGMMQPLSGPHRLGAETRRIAIAYAGLNFRGPDKVRYRYRLEGFDPDWVDA
DNASEAVYTNLPPGRFRFRVQAMSLPVDWRQNDLLGEASLVIELAPPWWRRGEVIGLGIL
ALASVIYGFYLWRTASYRLRQRQLNTVIDRRTRELSDKNLALQQASQEREALMRQLEYRA
SHDVLTALPNRREAERVLQQWFDEAHAGGAALALALMDIDHFKRINDDYGHEVGDAVLSA
IGEVLSEQDQAHCFAARHGGEEFLLAATGLDAVQARALFERMRQRLADIEVDAQGMTVRC
TASMGMAMSEEAPSRRELLALADRRLYEAKRQGRDRLIGP
>A0A5C6CVQ6|diguanylate cyclase|EC 2.7.7.65|Novipirellula artificiosorum|TrEMBL
MTPFAIAKQALGFVAQFRTPPTPDVYEVWYRYAEGSNTPLCEQLSYAVNDAESADAELLE
QLHQQFFTSGDQAELNQQLGEGLSKTIGSVESIIHDQQSAGNAFQSSVRSASASLDEDAA
TVDDLKACVASVLQSNHRMQEQLSQMASRLEESHRQVTTLRDRYFESQKKLMTDPLTGVG
NRLFFDTIIASALEHQERGKRHFFLLLVDLDKFKLVNDTFGHAAGDQVLRFVATNIERLA
GDASVARYGGDEFAIFLNSIDMDEGVHLAETVCQFFAKNKMTLNDTHEYLGQLTSSIGGA
LLRANDNHETWFERADKLLYSAKNGGRNRVMVERKLD
>I6CNP6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri K-315|TrEMBL
MIINQVPIKIKIFILLFSCISIIFLLLHENNGIYITQTTQISYSIFIIGLFFINLMIFIF
LLLYYVSNQRQSYLLILSFAFLSNTYYLLEVAIISLSPLGNDLSTIYQKSNDIAIYYLFR
QFSFISIIFLAVYSTNVKNKSVLEDKRNIIIVVLSILILFITPFVAKNLSSDNIKYSLNI
IQYSLNRHLPTWNIVYTKIISVFWLVLLISSCISIRNYSKIWLCIILISIVSVCNNLILL
YFIDKSHPAWYMTKFLELISMIYIISTLMYYVFRKLNYANHMAIHDPLTNTYNRRYFIDS
LKNISKHHDFSVIMLDIDSFKSINDKWGHHMGDQVIVMVTRIIKKSIRKEDILGRLGGEE
FGIIIKGNTQKLLLSIAERIRKNIEEQCSEKLLSHGPEKITASIGCFTSKENNLSPSEML
VNADKALYQAKRTGKNKVIIHSK
>A0A7I7E023|diguanylate cyclase|EC 2.7.7.65|Enterobacter kobei|TrEMBL
MQRDTFVVKQYFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVATSLDRQLQYSVDKMLFFRTSMHDALQTPLGFDVLRDAVSRFSAVRTDETWQLAVDK
KRTLPLNGVSDAFVAKSTLLNRDSERISNEISAALEVGYLLRLASSGVQSEERIIYVSRA
GFYLSTDTPDMADDISARYYFLVTQPWFTLHSERHNRARAVRWFISAPSPWSNGERTITA
SVPIYFEHYWYGVVAMDFSIHTMKRLLTEATQDRTEGEYQLYDTRLNMIATSEVDGSQVN
RFDEVETAQIAHAIEHDTRGGIRLGSRFISWERLDHFDGVILRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLVSWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFERAKGIA
EICRQQGQPFTVIQIDLDHFKCINDQYGHQAGDKVLSHAAGLIASVLRKNDVAGRVGGEE
FCVVLPGSSLEEGRRVAERIRSRINSREILVKKSTTVRISASLGVASAQEKENYVFEQLQ
SAADDRLYQAKQSGRNRVCWSDQEKK
>A0A8J7WT09|diguanylate cyclase|EC 2.7.7.65|Actinocrinis puniceicyclus|TrEMBL
MNAVQDDGDLMCCAVAGPPEMREALLGNTCARKPLEDLMQSAEAWGNLRFIRGLEDAAIP
EGVHSFPAGIEPQPRDGECWQPDYALLAPMRDSAGELIGLLSVDDPSDGRIPAPWVRDVL
DLFAEQAGFAILNARRHEEAAARMARLEQEHQRLREDIEERHRREQHLRHQARHDALTGL
ANPTELGERLVTLLADQIPLAVVFCDLDRFKEVNDTYGHSVGDLVLRLVAERLRAAVRGE
DVVARVGGDEFVVVAAGIGYEEALALVDRIDQAFSHPVAAGDSRLLVRASLGLAYEPSRP
ENVLAPEERAQELLGSADREMYARKRSRASFTRLTARALARRASVAG
>A0A6G9RIF2|diguanylate cyclase|EC 2.7.7.65|Kluyvera genomosp. 3|TrEMBL
MEMYLQRMKKEWLTLLDQTEPHIRQQAADIAVAHAQALSVEFYRVVLADPHAEEFLSNEQ
VEKQLKTALEKWLIDILSCNVEDVEGLMAAQHTVAEVHARIGIPVELVEMGFRVLKKLLY
PVIIYGPQPSADKLQIYHFAINSIDLAMEVMSRAFSFSESSMAKEDENYRIFSLLENAEE
EKERQISSLLSWELEIIYKVVLDADIGNTLPLSQSDFGLWFNHKGRHYFSGIAEVGHISR
LLQDFDGILSAINDTTKPLNAKTHRNKFLLQLRSTVSQITTLLRELFEEVSRHEVGMDVL
TRLLNRRFLPTIFKREIAHANRVGTPLSILVIDVDRFKHINDTWGHNTGDEILRRVSQVF
YDNVRSSDYVFRYGGDEFIIVLTESTAHDTLRTAERIRSRVEKTKVKAPDGEDILLSLSI
GAAMFSGHPDYERLIQLADEALYIAKKQGRNRVQMWKPG
>A0A221USY2|diguanylate cyclase|EC 2.7.7.65|Arenibacter algicola|TrEMBL
MDTLTRTITIEEAPIAIATLDTNLCFINCSTPWQQEFTTQDKNIIGKSFFDVVPSTPTLF
RKILENSFSIDDNIVEEQKHIMPDGSNKWYQWSIKPWKDTDGAIGGLIITCTNITKIKRS
KDLLIAAENVAKMGGWDLDMITNTIHWSRITKQIHEVPLDYVPCLETGINFYKEGEHREK
ITELIQNAITNGEEWDTELQIVTARGKELWVRAKGMPEFVNGKCVRLYGIFQDIDKKKKA
EIKNAQIKERLDLATEVANIGIWEYNLHKDELEWNDEMFPLFGVKRKDFKGNFESWKATV
HPDDLERCLQEFDMAVSGIKDFKTEFRIVHPDGTIKHIKANAGIFKDNEGKIIKMVGTNW
DITKLVNTQLKLNKNEESFKGSFKSSAVGMALVAKDGTWMDVNDTLCLSLGYSRKELLQL
SFQDITHPQDLKKDLSQLQRLLDGKINSYQLEKRYFHKKGTIVYVVLTVTAVKDIEGNIS
HFISQVVDITAKIEAQKKSEEFLELTKSQNDSLLNFAHIVSHNLRSHSSNLSMLSTYLLE
EQGESEKKEIEAMIMNASESLNETVMHLNEVVQITTEAKGQLQDVNLNHIVKSVEKNISA
LLNQKNVECHISIDQSIKVKGIHAYLDSVLLNLFTNSIKYSSPNRIPKIMIEATKTGKFI
TLNFRDNGLGINLERHGKKLFGMYKTFHEHEDSKGIGLFITKNQIEAMNGKIEVESAVDK
GTLFRITLVAA
>A0A484XJY0|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MSQHSFDALHLITTPVWLISPVSEQILFANAAAAKVMCNKTLNEMRRGIYSASAQTVLSM
YVADLKTDREIIEIWTVWRDAQETTLSCRLTLNHIEPYGDIILFEGLPQQAATGLKASRS
ATYQRKKQGFYARFFLTNSAPMLLIDPARDGQIVDANLAALNFYGYLHDEMCSKHTWEIN
TLGRNVLPVMTEIARLPGGHKPLNFVHRLADGTTRHVQTYAGPIEIYGDKLMLCIIHDIT
EQKRLEQELEHAALRDSMTGLLNRRQFYAITEQTNPSHLPAQQQFSLLLVDTDRFKDIND
VFGHLKGDEVLISPFENAGGLLPER
>A0A7U9S4M8|diguanylate cyclase|EC 2.7.7.65|Lachnospiraceae bacterium|TrEMBL
MKLLKMHLTEIAVAVLFVLLVICFYRVNDGGKNRTGNISYNENWSCVTEEGSREYRKLPD
LIEVSGDKKEIVLRKELGEEADNASSIGFFTTHQEVEAYVESQLVYQKKVPKYVKSKTPG
NCWNFIPVQENYRGKTLEIRLKNCYKFNYVRLPKFTYGPQSSILLQQLEDRALSLVFGIG
MMVVGLMLVISWCTIGKKMHFHEGILWLGLFTVYFSIWSTMETQIPALVFERELLCNQIT
FLMLKMMILPIVCFIRVVYQMKGSRLWNVFAWLGVLDFAVSFIGQFFGWFDYRESIFFTH
ILGIAVILAAAVCGGRILVERRQEIFCRRRKIYRNIIGICLVGGCMLTDAVNYYHRAYED
VATFSRVGCLLFILILTAEFLEDSMNLIEAGKQAETLKEEAERDGLTMLKNRRIFEIDLI
GVPENELKEYEIVMFDLNNLKRMNDEYGHHMGDYYIISGSEIIQDVFGSLGEIYRIGGDE
FCLIARGLTRQDYIKRAERMGSWMSSLKGAHVEGLMQIASGFAAFNRNTDRNLLDTMERA
DKEMYQCKRKQKAQNAQGGGC
>A0A484XT83|diguanylate cyclase|EC 2.7.7.65|Enterobacter cancerogenus|TrEMBL
MAICPVMVSVSVAAINSLIRQVSLRADYDFLTHVYSRSGLYEALKQEETHKHSRFLTVML
LDIDYFKSINDNYGHECGDKILTAFAQKVQQVVGEDGLVARMGGEEFAVVANTGDAQRGF
ELAERIRLTIANHPFTWRQQTLFLTVSIGLGSGKADPRVLTEVFNTLLTEADDYLYRSKK
AGRNRTSARMQDDTIVADAERDAEEA
>A0A128EVW1|diguanylate cyclase|EC 2.7.7.65|Grimontia celer|TrEMBL
MKLHTKAVISIAIFCLLTVVPMVVMKRLSDSALIESEHLSVLAKESSEFAHHFQAVINTE
TEIGQLLATNHYLIHVLRDANTPPNKQSEINKKAASDFLIHFSKNIRAGVYQEILVSDKH
GNIVAQTIQRDSDSVKQEPWWQKALNGEHSLIFTSPKFHSNTDYILGITQPIKQEGATIG
ALRLNLNLSQTFRHHEGFFDNLHDGVNALLMNHNGEVYFAKSPIGREYYLEILEAFDNGI
INGTNTTKLPNHLVGMTTLKLANHAKDDHSNTASANYFSAPHIFVVSEPITLINHFQNEN
NLGFVLYSALFITVAFIVIVGLLRQTGNDISTLTNVAFRIGQGDLDARSDINRSDELGVL
AKTINEMASELGASQTLEKELKQHVTDITRSNAKFRSLASVDELTHLLNRRAFNEHIDAQ
INRFKRYNEPFSVILFDIDHFKRVNDEAGHFTGDEILKRIAYLIRNLLRSEDVFCRWGGE
EFIALLPHTHGSDAVCLAERMRLEVAKDNFDGFPHVTISLGVTEFEKGDDEKTVVTRVDT
AMYRSKNQGRNRTSTFYRDANIRDIESPN
>A0A5B8QZV8|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MFADFTVFSWLLFLISALCLILAGATLKIRYQAVTIWFIGLLLAYAIQAFGYAFELTSHE
LDSIKFWLNIEFVGACFIPTCVVLFAVSYQTRTSPPLWLVSSLLSISAIVLLGQLTNDLH
GLGFNIVGLEKMDNISVTTNHLGWLYLAYSLYIHLAVIVSVIIFIRCMQNTHPVLRPQIL
LILVGITLTWLNYIWTLIGNTPYGLDMSPFGLFFCTIAFAISVFRYDLIKLTPIARDQIF
HQVEQGYIVIDEQSRLIDYNPKAKIFLPTLSTGKIGQPLSSFIDPSLVADNQTKVIRLED
GKRVQVQRSLMGKNAAMAIGSVIMLSDVTEKEQLLEEMERIANTDSLTGCHNRHALYCRL
KQQIIESRHQLTPLSIVALDIVSFRKVNEVHGYTIGDMRLKQLSHILNHHLPSNAILTRY
IGDIFIIILPGYRLEDANQVAQQLADKAKQLTSLAISTFCVQHLSEESDRQVIDRLLGEA
MQLKKLRPSLAV
>A0A5B8R2H8|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MDFRVLALSLFLWLFPLWASANDQLDNLAEMVYQYPTKALAQITALEKQQTSDNTNDINQ
LRLNVLKCQNFLQLGENEAAINLAQMGEASAKQLKLDQARPYFLNCQADAYLNYDNIQDA
LPLLDSAITLARRYQQPQALIDALRLRGQLDTNTDNFSSAIEDLRIALDIYPDINSQTQN
WVWPPQAYVYAAMGNLLYATNDLPQAMYYTKLALKSADAKGKVRHVLLRNAARIALDNND
REYSDQLEKQAKILLPEIGSPLELAYSYAILASIALDKGKIDTAEEYISIAMNTFKQQNQ
KVAMMRSTRLLAQIRFAQNRDEAAITLMQSAIEQGEALKQYTDLKWFYGILSDYYQTHNN
YQLAYEFLQKRFDAAELANEATNNTRILQFKARLNQQGLEQANSDEQHSHTSLLNDLNLD
WAYSTLFLVIMALTGSAIWYFIDKQNNRAPAADASPKNIPPLEQLELTLHSAKQGDYPLS
LLLLNASQIRQVDLPGLLDKLQDKLREQDKLLRYSIDEVVIVLPYTSAVGAQRVVNQITP
TIQTLQGTSKVNIGVAVMQQFDTLESLVKRASINRLGKLKGSEPLNSYSPAK
>A0A5B8QS45|diguanylate cyclase|EC 2.7.7.65|Shewanella decolorationis|TrEMBL
MFRDEDETTPPRAHEVERLKKRLNRLKYLANKYKRAEVVQNALLELSHIATQVPSLEEFY
LGVHHHLKQLISADNFFIATLDVTTGVISVPFFADEKDAHPSQLYPEQSLSTLLQQGLTG
YVFRTGETLLCNDAKVDELVQAGEILNLGSPCHLWLGVPIKHEDTVTAVLVVQTYDTNVS
YGDIEVELMTFICHHIAGVMERLKHQEQLEQAIQQRTKELSQAYDKLKQEVYERRRAERL
QKSLFEIAELASSGSDNPDFYAQLHNVIRHLIPANNCYIALLNEAGTHLTFPFYVSQLGN
QHPGTRPLQDGLTEYVLKHKRPLLLDQNDINGLIASKEIYAKAPALNHTQTMHQWIGIPL
FIHDEVRGALTIYSFSMTQNYQTKDLELLTFVSQHIGAAIEKKLAAESLRRSYEDLEEKV
AARTTALAELNKDLEKEIRQRRNMEAKLVHDAKHDALTGLPNRAMFMERLNQAIKHVRRH
SLEQFALLFIDLDRFKQINDTMGHLEGDRFLIETATRLRGCIRSNDTLARLGGDEFVILL
DTINGINDARDVAERVIQKISQSYKLGSVELHSGASIGITISGNKLDTSESMLRNADTAM
YQAKANGKGCYVIFDDSASQQKMQDIAFENDFKQALHAGELQLSFLPIIDLHTLKTQALE
CRLIWEHPQWGTIPQDILNKLAEQANLMVELDKYLINLVDKSQNQLHVSHGETIDLHLML
SSQHLKHKHVLRGLKNTLKQTQLVMPQLWLFFNEKALVQETENHISGFELLKKLGVNLGI
SHYGSGHSPLNSLLFLPIKGLKLDANITKQLQDEQHIKLMSAYQKAASTLDLQTFVDGLQ
STEQVKIFHSLGYRFGQGRALAHPFPLMKIEQQVCA
>A0A731RBC8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 42:r:-|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMTH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRCDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A657I5X2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Crewe|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A2K8L6F8|diguanylate cyclase|EC 2.7.7.65|Mariprofundus ferrinatatus|TrEMBL
MSSDIDNSAPVGMRQSHSIMVLLVDDQPIIAETLRRMLDGESDIDFHYCLDAGEALDMAA
AIHPTLILQDLIMPRVDGLDLVREYRRHPECREIPIIVLSAREDPKVKAEAFARGANDYV
VKLPDRVELLARIRYHSQWYIHKRQRDEAYRSLQESQRQMENMNLKLMHLSTHDSLTNIP
NRYHFDQMFSGEWSRSGRDSTPLSIVMIDIDEFKKYNDALGHPAGDKCLAAVANVLSNNL
HRPADLVARYGGEEFVLLLPGTDAAGAKVIAEKMASEIEKLKVPHPDSSVSDHITISLGV
AATIADRTGRPDSLLHDADEALYAAKKAGRNQIRVAGE
>A0A679KDL5|diguanylate cyclase|EC 2.7.7.65|Methylobacterium bullatum|TrEMBL
MPDFYTLYLVVLIAGLSHCVLWASVLYRYRELAGVRYWLAGSLAKVAGGILLALDGGVGN
FATTVGGNAVACLAFYLNTVGLRRFHGDEPRWALHAGLLAASVLAMALTWQPWWGQNPLY
VTSQCIPLALAILYLARRRIRELGALITMSALATAITAHGIVACAVTVRLSGIAPDVSLV
SLAAIDLLVFILAGIVWNFGFLVSVVDSLMATVERLAAEDDLTGLPNRRQFMRQLAGECA
RETGEPFSVMLMDLDRFKGINDGLGHVAGDAALQHVADAVRGSLRPADVFARLGGDEFGI
LLRGIEGDAATEIAEQANAALRASPFLWRGETIGLTISIGVTSAVPGRHHTPEELIECAD
SALYATKGRTRDGWTFLPFASRPGFGAGQAGGAKAARLPDRASRIPLAG
>A0A6J4FZA1|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum sp. LM-5|TrEMBL
MNLNAKVTMFFAAMSIGLLVILVAISLYAFRSFSIVSSSEHIRTAAEIVRVHLTESMING
VIDKRESFLKRLMEVQGLASARVVRSPMVEQQFGKGLSQETASDDIEIQVLRDGKAQYEI
VETSDDTLIRGTIPFIATNRGSPNCLECHQVQEGMVLGAVTMQVSIGSLKNKALLTVGGI
VVVVTLFSLVAIMLIRRMIQPISTTAENVEVAVQRALRGDFKAKVDQLTNDELGQIATDM
NRLLNFLDDGLNRIGANVARLTSRTPSPDENQLTATIDMVEGLTKAAHFKQAIEEDETKA
EIHQRLAKALSGEFGINEYSIYEMVANKNQMTPLFVDGVSSDSCRWCDPQILVRSEGCRA
RRTGHVVDGTLNPGICYSFLPPEGETGRNHICLPVIQSGGVGNVLQIVTKDADETRIQGL
LPYVSVYLREAAPVLETKKLMETLRESSLKDPMTGLNNRRFLEEYVDTLISNVQRRKGRL
GVMMLDLDFFKMVNDTYGHDVGDVVIKTLAKVLRQTVRTSDMVIRYGGEEFMIVLVDAPP
EDVDLIAEKIRASVEAMEIHAGTVSLKKTISIGVADFPNDSDTFWQAVKFADVALYQAKE
TGRNRVIRFNPDMWTDKQY
>A0A3N5DXB5|diguanylate cyclase|EC 2.7.7.65|Buttiauxella warmboldiae|TrEMBL
MKNTQPVNYDVIKNEWQLLINKTNTATHQTLIALSDEEIGSLVDAYYQYMLQDEKAQLFL
STSQVEERLSASMINWLRKVLGSSREDLSELIAHQRKVGEVHARIGLPIELVARGARKLK
YELFQLLLSKAQLTAAEINQAIFFSGMAIDSAIEVMTVAFTPSHQKMMHDQEHFRLLTVY
DDMSVERERQLGALKDWENQFIYNVATELPFEERVLLSDSEFGLWFSHKGQHIFRQPDLI
HKIDSLIQKIDRLIATEFANDSADMLSRIHLLRLLRQDVEQVNMILSSIFEEIVKSENGK
DPLTRLLTRRFIPTIMRREIALSIGSGKSFTIALLDIDYFKQINDSYGHSVGDNTLKSIA
VWLHEHVRSSDYVFRYGGEEFMLLLVETPLAQAQTLMERLRNDIASQVIEVDVNTSFNIT
ISAGLAEFDNHPDYQWLINKADKMLYQAKNNGRNRIESYSLGIEHTL
>A0A829AS78|diguanylate cyclase|EC 2.7.7.65|Escherichia coli KTE119|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1V5HWS8|diguanylate cyclase|EC 2.7.7.65|Tenericutes bacterium ADurb.BinA155|TrEMBL
MDPNLTPEGFQKEFNRLSAVNPQEGYSYAKTVLARKRIKNPQTRQLAAYYEAMDLFYQAR
YPEAEALLKTFLFSYEKYPFKPFYVDCFIILAALMFFKKRYYLSIFFGQQALALAEEKKL
PDRYSTIYSNLAAPYREIKDYDHCLLCLNRALNYVGDEADPALKASLIYNQAAILLTMGR
YLESRERLEALEALIAPLPVKPPFLNFLPLCKAEVALALHEESNLHKLALDFLHSPLRSD
PEATSFLLEDDEDLYLLLVKSGLYEDAKLYLASIQKAEEAAPSLATELFIAKAEQAEALR
TKDGEGLAKANAALAKLYEAQQESYTKDFAEITKLHFDFVRMESAYQKVTKRASRYKEES
DTDALTGLMSRRALEKEKARVPLLAKKGKYLVLALLDYDHFKSINDNYGYQVGDLALRLG
GQFFKGYGSVTRRIFRYGGDEVVFLWSVDSFEAIAPFFKEIQAGLAAVDLRTSNGTKVPL
SCCIGYTVYPSEAYPEFPVALKKANEAIHEAKTSGRGNIVGKD
>A0A5B0KGY4|diguanylate cyclase|EC 2.7.7.65|Pseudocitrobacter sp. 73|TrEMBL
MVMKKVSRPVFVVPTHPVLRLASLGLVTFIFTLFSLELTQLGALLAPLWFPTSVMMVAFY
RHSRRLWPAIAIACTLGNVAASLVLFPLHELNLIYSGINVAEAVVGGLLLRKLLPHYNPL
QNLHDWIRLAIGSALIPPLVGGLMVYLLVPGDNPLQSFIVWTLSEAIGALALVPLGLLFK
PHYLLRHRNPRLLLETLLTLAVTLALSALSMIYMPWPYTCIIVFLMWSAVRLPRMEAFMV
FLCTVMLVSLIMSDSTLSQHVSVVYTVTNASWMPFVMILLPANVMTMVMYAFRAESKHIV
ESEERFRNAMEHSAIGMALVGTEGQWLQVNKSLCQFLGYSPDELRKLTFQELTLPEDLDS
DLSQRDSLVRGDINTYTMEKRYYTRQGEVVWALLAVSLVRNPDSTPLYFIAQIEDINELK
KTEQVNQRLMERITLANEAGGVGIWEWDLKPNKISWDKRMFELYGVPSHVKPTWQVWESC
LVEEDRENATRKVLNSLKSSAPLMLEFRVKLKGKVRHIRSLANRVLNKQGEVERLLGINI
DMTEVKELNEALFQEKERLHITLDSIGEAVVCTDSNMNITFMNPVAEKMSGWTQQEALNK
PLLSVLHISVGDHGPLMGNFHTGDLYRSDIDDDLVLHSRHGGSFDIQYSITPLSTLNGEN
IGSVLVIQDVTESREMLRQLSYSASHDVLTHLANRASFESHLKRHLLNIDNAQERHALVF
IDLDRFKSVNDNAGHAAGDALLREISALMLSLVRKGDILARLGGDEFGLLLPECKEEDAH
DIAQRIVDGVNNYHFTWEGREHHIGASVGITFIDRNNTSLTDLLSQADIACYASKNNGRG
RVTIYGTHPDAMPRVQNRLSQKE
>A0A2U3KY89|diguanylate cyclase|EC 2.7.7.65|Candidatus Desulfosporosinus infrequens|TrEMBL
MTIGHVSASLYIGGFFFRYFVRSETISLPLMLPYAVVALFLYFMVSRTISCMIISYNNNS
SFKKQLAKIFHDINWGYCNTYSTGLITAILYEAKGPWSLLLSLPLLVGTFKSVSYYSRNH
ILQKAVSTDALTEVENRAALESFTVYMQMHPLNGTAVMIDLDNFKKVNDEMGHAFGDTLL
RQVALVLKQNIRDLDHVFRFGGDEFVLFLPHGPEDIESIQERITNLINLVYVECYKLGVS
TQASVGIATIPNDTCDFKTLLAIADERMYIAKSERPN
>A0A375H220|diguanylate cyclase|EC 2.7.7.65|Cupriavidus taiwanensis|TrEMBL
MRPRLANLLDRLWEQAVRTPQRFVVLSFAVAAMLLVLFFGYGLALLRDHQIQSLQQDQQL
QVAGISSVLNVEAERVMSVRAYAQHLIRLQSGPHAIAPDPPLKAAFDHRNDAVWTMPAPE
GDAVLVGVSPATLANLDGFSRRDADLLPGLYVARGLSHLISAEPVNPLVARKLLYVSTNG
FFVAYPPVPPAEAAATLRHIAAAGYLREHQPQDNPGQPMRWHFAPAADGTPDGYLSLSVP
VYLDRQFRGVAIMEIPQHSLDAYLTRTTRPDVQRFLVDADGNLVGASTRDVRRGETLSAV
LPASWHEATAQEMFRRGSGTLRAGDGSRILFQRIGNSSLALVDYFSATDLLLRVASHLSA
VLGASTLALALLMWVTLQGIGKLFSHYQARGEALRELAGTDTLTGLANRREFKARFDIEY
QHSRREQTPMSLLMIDIDRFKRINDHWGHASGDRVLTALAGVMRATVRAIDLPARVGGEE
FAVLLPRTALDEAVRIAERLRRIIGQTTCAPAADAADQAEIRFTVSIGVSDMGGDANDSL
DTMMQVADRRLYAAKAAGRDRVVSDDRVAESAAAPAQQPPAVASHIGR
>A0A6N3R0L2|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri CCH060|TrEMBL
MFALCDVNTFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKD
LFRRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFG
REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGWWIYQIWNASVN
>A0A5X3QZ62|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Saintpaul|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A378KPF9|diguanylate cyclase|EC 2.7.7.65|Legionella gratiana|TrEMBL
MYFTLIMIIIGIFFLLGGAIVVWPLIKKASYYHYQWIANLVLICFFIGSFLFVIVYTLLI
NEFFTNYFYATLFLLGGFYVFWMSYLSSKTIEKIKTMDNLKLEYEKIRYNAEHDKLTGCF
NRHYLMEILDNRFRKIKLNTGQLTVMFVDLDGFKKINDEYGHDFGDQILQRFGQLLKQQL
REEDIIARYGGDEFVVLVENIPLTKAKSIGQKIIQTTSRITKEKLPNHSSLGCSVGITQL
TKNSLSINSVLKKADDACYKAKKNHGNTIWVDDNMTSSFLD
>W7PAD1|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. DC4|TrEMBL
MEKRKKPTLERATWPTRHAMVMHGLAMNLPWLAFVNISFAVMILLRHVLLKASDPLYPHS
PQLTRMVDASMLGIIILSAALILMAWRRIAGISVVLFICSAIWSVSCFWFITQLLLPHVW
PLCVILLLAGLTALYFYPEGLLAFVLPLWITLPIASWILNDGLNLHFVVIWSVFSLILIC
GRFILLSWFDEAWRRNQQNQLLISRLDALAHQDPLTKTANRRKMEVVLENAVEQKKTFSV
IMLDIDYFKLYNDTYGHQAGDDCLTRVARVLKQSVRTPDDVVSRYGGEEFVVILFNCPEN
IAEKVALRIQDGLRAEAIPHSASTVSDHVTVSMGIASMAEGLAGTEIIARADAALYRAKE
AGRDRVCR
>A0A238D148|diguanylate cyclase|EC 2.7.7.65|Thiomonas delicata|TrEMBL
MLLMDATRQRTPHQSRNAFWSFVSMGFIVWSTAAFGYGFQSWRAVADQVWLQLDATSVLA
KSVTQQNLKQYFRGFNFLDHHLKADAPAFEHADPQAIFALLRQFRRMYPDFDVIDVILPD
GQVVADASKQDQRAVQPITEAYLRELRQRQDLHTTFPKDAASAAGLAVVRLGFAQRSASG
AIAYDLVADIDLHRQIVSWLRPELASDMARHLQMGLVTRQGDLLGLWPEPTGPTIYAARL
AAWFRLHALSPSPRHPLVVTPAHGVGPIYVDDSGTDRIAWSALAPLKGVPLETFVSVPRA
TVWDAWWQQVRLPLLEWALLGVLLALMALRLNKLQRLERQRTLRLEQAERTARQSSLFYA
ALAQTTQALMGHKAGDVSATFQDLATSLCVLLQARLVCVGRLPPERSWVDMAACAGPASD
FAQHLQRNIDGNRPEGWNPGSQAITTGKPQHATIESPEFAPWRQRAQACGIAGVLSAAAG
TQCGEAVLVCAYYSSESVIGPEAGQVFQRMADAFAECIDRQANIVKLERIERYRSARRKI
QRGLLEATEAAGVYRILAQTLAAETGADVVEVFAPEGDMLKRRVIAGPLEQALSHLTDVS
LQALARGEGAYMRARVWNARAPVLIQTPSADPKLSPRWREPALCDMGLLAGWPILAVDSG
EPMGVVILVARDPHAIDEELQHLVTNILESAAIALRQVRDRQRIETLALTDALTGLPNRR
SILEHIPQALARARNRHRQMAIGILDLDDFKTINDTWGHAAGDALLCEVSRRLQITLRGA
DAIARLGGDEFVVVLEDLVGPHDLSMVLDRLETELTAPYTLPGGQSTPMRISLGLTIYPS
DDSTPDLLLGHADEALYDVKARKGSRRCGWQLWNPGASSDDHSDRCPAAHDGPAHDSLNL
ENDTACNAT
>A0A841EUW4|diguanylate cyclase|EC 2.7.7.65|Paenibacillus sp. JGP012|TrEMBL
MLSTFFVNLCVIITFMYLSGIVAKFYSIRLPFPSLRVQMIGGLLFGLYGTVLMNYSFHIN
DSTIVDLRHLAVVTAAVYLGGLASVISGVIIAILRILMFGITSSAIDGAFIMILLGLSGV
YFAYASWSRLTKIITMNLLGMMLIFVALLMNTDSMSTLMKVYPIQMTIAFTGGIFIYFIA
EFINRSNEMLFMLERRASTDHLTDLSNRRQFEQSLRAELHHARHYHQKLSLLAIDIDRFK
IVNDTYGHSAGDAVLKQLGQLLVAHARSTDLVSRHGGEEFAILLLDCGYHQSITIAESVR
KAVARFLFALPDGQTVKLTVSIGIAVYPDHCDDHDDNDLFDQADRALYEAKNTGRNRVCS
LPPRNTTVADEDWL
>A0A3S4E5E2|diguanylate cyclase|EC 2.7.7.65|Salmonella bongori|TrEMBL
MVNRYQTYRLGGDEFAMVLYDVHSKYEVQRICAALSQEFNRPFELHNGKQVKMTLSIGFA
LAWEHTSTEKLQELADRNMYQAKHRRTKRLLK
>B5XPV4|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae (strain 342)|TrEMBL
MDKPLRLKINKLRHLTRPAHVVNVCFIVVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQSALEQPLDIDVLRSASQRYLSQRHQEAWRVALPNRRTL
PVFGVSGSVVGNNPMLLKDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVMTHYSQAIGALWFTRQSQRNNPGRGVIWQTFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQEGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASACQR
SGRPLAVIQLDLDHFKRINDRYGHQAGDRVLSTVASTLASTVREGDLLGRVGGEEFCVVL
PNTTLQDAVAVAERLRLRIQGREVFLHNNVTLRVSASLGVSTSEEQGEYQFEALQSVADR
RLYLAKQNGRNQVCFRSEA
>A0A2R8BGZ6|diguanylate cyclase|EC 2.7.7.65|Ascidiaceihabitans donghaensis|TrEMBL
MKASDNFLSMLDTLCPMHVVLNSTGHIVHAGPTTQKLHPNGPSLIGQRFLEVFVLKRPRA
VASVADLLNVSGMKLHLQMRDPPMTELKGVLVPSLCEGQIVVNLSFGISIVDAVGEFGLN
CGDFAHTDLTIEMLYLVEAKSAAMEASRKMNLRLQGAKIAAEEQAFTDTLTGLKNRRAMD
HFLERYIEEDRSFALMQIDLDFFKAVNDTKGHAAGDHVLQVVSRIMVDETRETDTVARVG
GDEFIILLPSAQSEASLSSIGGRIISKLEVPILYQGEHCQISASIGTAFFESGCELTADQ
LVSNADVALYASKDAGRARQTFFNPKLRHSVTQLVPQNRKEDFAPDVRDAS
>A0A173R1M5|diguanylate cyclase|EC 2.7.7.65|Roseburia intestinalis|TrEMBL
MNLRQNKEKNAQQMLTGVILTLFIMLLLCTIFTNQDAASVSKLKARQPDKIQYLDDGMVL
LSFNINRNENSRGSLVFFTSHQHVTVFTKNNVIYNLDDSGGIWGHTTGNVWNFVKLPAYT
ETVIVRLKPCYPETAGQIEQYYIGTGNEIYTGILRQSMPTFIASVFILLAGFFITCYWVF
IHNSSHIDGTLFYLGIFSILLGLWATNETDVCSLMLLNRRSSAFAAFMFLMIMPIPFLMF
VKSFLEINDDKIWKIFCNLCMLQTVVCSLLHFTGFYEFRRSVWITHLSICIVLIYLITVI
IYKIIKKQADQRLKVCMAALAFVVIATIVDIASYYKTRNNSGIWGRLSFLVFIIILGLES
ARQAVASLKKGRRIEELEQFALNDSMTGFYNRNAYDYFIYNEKNIKNYMVVTFDLNNLKM
CNDNYGHSSGDAYIIHSAHIIETTFDRFGKCYRIGGDEFCCLIPDAAEFQIERFIQKMQQ
DIAILNNKNIIPTEVGIACGYALATPDDADIEKVRERADEMMYHNKKVLKGLI
>A0A4V0A9Y3|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MANTLVVNTLANLGAIIINIYLLFKVSDGFVGQGTFKAKQIAAAIVCETVVGMLLMNFSY
VVYETRFDLRFLLYAFSMKYLGWKVTVPTMFNLALGRFLFEVSKSSWLNLYLSFFLMVTL
TFLHAWAKRRLSDKQELILSITYLIVISFLFGCYLTGDIQKTTLIYIVYGILAYTLAFFL
YSILNDMQRILALVKIDDLTQLNNFRKFQEDRQRLDTTEVDLSIALIDIDHFKNYNDRYG
HRAGDVILQEIARIFLNYCTASNPVYRIGGEEFAILIQGDAQAAAYLLEKIQKRIRYQEI
ILDAGDSVSITLSIGIAQRQRGELLMQTQERADQALYRAKRSGRDQLCLY
>A0A560DDL3|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MDSQKDRKAAILATTLSSLWTDTEPAVRERVTAIALADADAISDVFYAILLDRPDSNAFL
SHTLVQERLRPSLARWIAALFTASTDEAIAAVLEQNYQVGLIHARINIPLTLVNAGMRIV
KKELSTRLLAADLSRAQTASAILFVGELLDTVLDNMHEAYLGDLLGNVRHQQSLKMFMSG
PNLALEGERLKSSLFDWLRNAVVSFYTHEGSNHASPPPIESSDFGLWLNHKAELTFGRVT
ELDLIRERTTRISAKVTAAVEGGLITPAFVKELNNDVTEIAYVLGTIIGKAMEIESGRDP
LTRLLTRRFMPAIFQREVAISLRHGKPFAVLLMDADHFKTINDTLGHQAGDSVLSDMAEL
LHTHVRAGDFVFRYGGEEFLVLLTEMDEASLRVKAEWLRQAVEDHRFPGAGGAGNGLRVT
ASIGAALHEGHPDYEHTVRRADAALYEAKRQGRNRVVIA
>A0A2X3J3Y9|diguanylate cyclase|EC 2.7.7.65|Cedecea neteri|TrEMBL
MLFDRQFSLIATAADRVSPAPVFNAKQQAEIARSMESGEEGELRMDTRFVTWAKLMNFDG
VLIKVHTLDEGVQGEFGRISIVLTVLWLLFTLMLFISWRVIRRLVNNMLTLQQTLSWRAN
YDTLTRLYNRGAFFDIAHGMAQTCQREEKPFSVIQLDLDFFKGINDRYGHHVGDKVLSHA
AALLASSLREEDVAGRVGGKSFACCCRAPGFQRRRLLPNEFGTASIPKRCFYRPDRPSKS
ALRLGLAAHMSGTIMILSICSRLPTVGCTRRSRTAATRFVRRTDVPDVSGRYII
>A0A4V0A9Z3|diguanylate cyclase|EC 2.7.7.65|Enterococcus casseliflavus|TrEMBL
MLERGVLLAFGLPLMIASLLVTADVFVRSVQKISVSRPFKYFIIGILTFTHLYFILSFSM
NSVGFICYQYTTAFIASHFLYGDRGKILILITPCMVVFYLWFVGFSDVGKAFYLPLFGVG
LFVLDFLLSKVKRIHPQQQFYLMYFLTCLLSPRFSMLVHHTTTYDWEAMLAVFVGSFVLL
GGFMWLHRLIEGEEYQVLAELANSKIDALTGCFNYGTYNHDLLQAVSQKKTVTIAMIDLD
HFKKVNDRYGHIAGNELLRTFASRTTTFLEAHFAETFSFYRYGGEEFCLVIEGDVKEKTV
AAMTTLCQTISSSMFPVANFEKGTMSLSCGVEASTVCHGDILAAVERADQALYLAKQSGR
NRVCTLPET
>A0A0S4L5V7|diguanylate cyclase|EC 2.7.7.65|Candidatus Nitrospira nitrosa|TrEMBL
MTSDEINRRILVVDDNVSIHHDFLKILRPDMGSEALEQARASLFGDSNPVRTNDEFTVNC
ADQGATALALVETAVKEGKPYAAAFVDMRMPPGWDGLETIERLWEADVALQVVICTAYSD
QPWDEIRDRIGRTDKLLILQKPFNSIEVLQLATALCRKWDLARKVSGQMTELSHLVDERT
TELQHANRQLREFNEALVQTVANLEAAQTEILRQNDELERLASRDALTGCLNRRAFYALF
EEAFAEGRGQGSELCCLMVDIDDFKRVNDEFGHAVGDQAIQAVADCLQSGLRLTDMVGRY
GGEEFCLMFPRTTLGEATVLAERLRARVAAEAGNRVRMASGMTLTVSIGASSSVFGSRAP
LELIDQADKALYAAKEGGRNCVMAMDVLVPGLNPSEQLELQVRRVTPRASTSAHIR
>A0A4P8DTT6|diguanylate cyclase|EC 2.7.7.65|Acinetobacter cumulans|TrEMBL
MPQNVSIQLSETWKSICDQYSALDHHLTVELITKNLDAFVAAFYKQMLLEPESAEYFSDN
IIQKRLIDTLKAWLLETFNVALNGQYESAVLRQQKVGNVHARVGIPSWLIMRGVREIERT
MFEYIASDNSTNYMNVVSYVVQLLGFSTEIMCRTYEDKTAKNHEVKHSYRLFSAMQDVAV
HKDRQRGSLLDWENDLMFKIFSGQGKFYQQLFSKSEFGLWFIHKASYAFTGSEQVGLITK
RIYEIDTLTEECMLLEGREQLMLMVQKIRSINREIQHLVDQLFQVTEYIESGNDALTQLL
NRRYLNTIVGREISYARKHRSALSLLALDADYFKTVNDRYGHAAGNMALKFIAETLQKFS
KGSDYAFRIGGEEFLLLLVDSDLSRAKMVAENIRMCIEDTTLQTSVGEDFNFTVSIGCTQ
YDGHPDYQRFLDATDLALYSAKNRGRNCVYVTEVQKMA
>A0A3P8MCQ5|diguanylate cyclase|EC 2.7.7.65|Tsukamurella paurometabola|TrEMBL
MAADARRPAELWGPVGLPHLLRAGARALTRRSGWRYAGRAEYEQATSWIKGQGGGIALRF
VVGSLALLMVPLCIGVLFSDARPRSTAAMIVFVVAASGSAVLGTWWLRLRRPRAQDAMTF
VAIADICLLTGCLAQFGIAKVAGTTYLGMLAMLTAFLLGWRILVVHCLFSLAAIAACTVA
AVQADGVAMGQLYAILAPAATIDFALPMLVQFIVEFGRRGIGVVTVERNRDTLTGLFSRA
GLQATLRGLVHRREHDTAVVAILDLDGFKAYNDTYGHLAGDKYLAETAQWLRGGLSSALI
GRMGGDEFVIVALRLGRTEADVVIGDLRRLVDEGGPIAGSIGLVVRPRLSTSDLPSAVGE
ADRALYTAKADRSRRLVVRDLTVRDADDSD
>N6X9S4|diguanylate cyclase|EC 2.7.7.65|Thauera sp. 63|TrEMBL
MHKSLPAQTTETIENDWLALFDQAPLGARAAVRDIIATHREAMADAFYERMMQDPEARAF
LSSEVVHERLHASMQRWLTTLFSCETREQFLTAMAMQRHVGEVHSRVDVPVNIVARGARV
LKNRIGGYLARSPLGRDELVEAVIYVDSLIDLAFEVMSSAFVASHERTARIDEAYRSFSS
GQNMSLERERQRSALLDWENRLLQTVMTGQPGDDLPSVSDSSFGLWMQHKASALFRGASE
HATVRKLMRSIDETLLPLCAQQLGAGNLSEVRHLLKQVQAEVGELKFLIESMFEHLVDLE
SGKDALTQLLNRRFLPAILARECEITRSEGKPFALLLVDVDHFKHINDAHGHQAGDRVLQ
QVAAILQNSVRSGDFVFRYGGEEFLIVLVEMDHTRAMRVAEKIRTRIAAEPLLISNGGQL
NVTVSIGVAMHDGHPDYQRLVNRADGALYRAKQGGRNRCEPDLPDANA
>A0A151AZA6|diguanylate cyclase|EC 2.7.7.65|Moorella mulderi DSM 14980|TrEMBL
MSLKTKVLLVFCAVFALLALIFFAVSHVIAGNIAGKLENESIRENMERALQALEREIAAL
DKSAADWATWDDTYSFVEDRNREYIEKNLVDNVFEILRLNYAVFLNTRGEIVYARGYDPE
AGEEIPLPPGIVFTAHNQTGGLKGVVVTPQGPVLVAARPVLKSDGSGPARGTLIFARTLR
DKDLKELSEITRLPLSLHPPEAIDFRELKPAGTLKNGEPFYVKIVFPEESAGFAVIKDLQ
GESALILQANSYRRAAQAFLSARQAFSLFLALAAALCCLLALFWLDRAVLSRLARLTAAV
IGIGRSSSSAPGIPLLEGKDELALLSSEISKMLERLEEYQRELGEKEKKYSSLVDNATET
IIVVQDGVVTFVNRATLAHTGYTAGELLSRPFLNFIHPEDRESAVQHYRELLEKKSPLYA
CSFRIFAKDGSVKWMETNSVVIEWEGQAATLHFLTDITPRKILEEELQRLMAEKSLILDS
LTEMVAFLDRDMHVIWANRTACQSVGKNPEELFGAKCHEIWQGKNAPCPGCPVVQAMETG
QVCTGEVASPDGRFWSITATPVKDKEGKVIGAVEATLDITERKRYEEQLRFLSLHDSLTG
LYNRAFFQEELRRLSGSREYPITILVADLDGLKLVNDTLGHAKGDELLQACAGVLKTSLR
RSDIVARIGGDEFAAILPKTGEKTGEVLAQRIRSAIEASNKEHPELPLHFSLGVATCQNA
AESLEETFKKADDLMYRNKLQNRASARNQIVGALLAALKEKDYITAGHAERLQEMCLNTE
LGG
>A0A241VEG5|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 4218|TrEMBL
MNTESIAVLAAQWKSVCQDFSTTDLNDTFQFIQAHSQTLVDEFYKDIMQEKEASYFLSDD
MVQNRLKTTLNQWLIDCFNVPLQQNFIEIVEKQLMVGKVHARIGIPSWLIMRGIGEIEKK
VFLLQTEQTQENRLAIAAYIVQILGFASEIMCRSYEVNLEKNNDTKHTYRLFSAMQDVSA
QKDKQRSSLLDWENELMFKVFSDEPKFTHSLLSKSEFGLWFIHKAAYAFTGTEQVSTIID
RIHQIDLLSQQVLNATEREQAIQLIQHIRENNREIQHLVDQLFQVADYIDSGSDSLTQLL
NRRYLHTIVSREINFSRKNNAPLSLLAIDADYFKRINDKFGHAAGDSALKFIGEVLLTSI
KGSDYAFRAGGEEFLLLLVDSDLVRAKEIAEQVRTRIQETTIRTSMGISFNFTVSIGCAL
YDGHPDYQRFLDAADAALYAAKNNGRNCIQVTKQVASV
>A0A735HKX7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae serovar 47:b:1,5|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVSRTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A3S4CA74|diguanylate cyclase|EC 2.7.7.65|Devosia equisanguinis|TrEMBL
MPAPRRTITNSLTSRVLIFVVLAFALVAVPSYFAFNWIVASTVIQLGTLFAEKQVLYDRH
RGLGTLIREVSLAETLAGSQAIRDWTRNEDDPVLKRRGIAELEHYRQNFTDRSYFFVIDA
SKNYYFNDAGNGYAGNQLRYAVSADNPRDAWYFATKSLGDGCHLNVDNDANLGVTKVWMN
CVIREGRTVLGVLGTGIDLTAFIQEVVNVPQVGVTSMFVDRRGLVQAHRDQNLVNLASLS
EDIRAKRTVFSLVDSPKDEAVLRGLMEDVTDGETLARSAFVDIGGKPTLVGVGYLDRLGW
YNVTLMDVDAIIDRQLFLPIGLLLISVMGLGTIMLVLVFKRQVLDRLVRLEGVVRSAREG
DYGPALHMGVGQQDEIGRLSAAFTEMATAVDDNTRLLEARVRERTRELEQLAFRDGQTGI
LNRRGFAEAHEQAAAAGDYGLMLLDIDRFKTINDNYGHAAGDAVVLEVARRIGTIMGTGD
SCARWGGDEFIVLLPGCAAAALRPAALRLMAAITEAPVIGPAGEQMAISISVGACLAERG
DNLDLAADMADAALYMAKERGRNMVVVFDAKMQMQPRTA
>A0A0Q0I7T6|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. P1-26|TrEMBL
MAANACGHDWVVEITQQEEEPELDQALINAVSELDEFSRFAIYINKFFKPGLPARLLNKD
SVIEELSEHEVNELIEKVSRNKIRISRNYGFISTYVPIYYMGNVVGVLVIESEKELSERC
SMLAIYMLNIYANQLSLLYKSQLDPLTELLNRQTFDKKVIEIAADAAVGHESHESKQRHW
YLAMVDIDHFKSVNDNYGHVIGDEVILLVAQLLKNNFRFEDYVFRYGGEEFAVLFQASDE
LDARNALNRFRGCVAEYPFPQVGNLTVSSGFMPIYEFEMVASLVQKADQALYHSKNSGRN
CVTAYSELDIQQSQPQDDSIELF
>A0A2X2H4Z4|diguanylate cyclase|EC 2.7.7.65|Serratia quinivorans|TrEMBL
MHTTELPVATKIQPALIVFLLVFATCIFGIESRPTGLLSAFWPTNAVLLAMLVRYPVLAS
RVGWVMAVLGYLAADLITGSTPGKAILLNGANIAGVAVGFYLFMRLSPQVRTLERTSSSI
FLFAICLVSAMATGILGAGASVLLFDRQYLPSLALWLSSEFTNYITLMPFILAVPTDGKI
YLRSIVQAITLRNQWYNTCRKMAVLILLLLACICSILIGGPGAVIFPMPILLWLAMSFSL
FTTMITVLAYVIWCHLAIDLGLITTNLDMKMLQNTVSMRLGVALLALGPIAVASMNFARN
ALLRKLEHVANHDALTHVLTRSAFMQRGTRLVSQKGERICIMMLDIDYFKSINDRFGHAG
GDTALLSFTRTITDDLRDNDLFGRMGGEEFAIVSPIAQLEDALLLAERLRRRVEIESITM
PAGTPLQITVSIGMVTCIGGAGQNLDNLLKIADLAVYKAKNSGRNRVATPELLQRIDSEL
>I4EQS2|diguanylate cyclase|EC 2.7.7.65|Modestobacter marinus|TrEMBL
MSSRTPGLLDDDGNDVTTLQGTDALPLHLDAVATAASLLRSTGTAVLDLDTAPADAELEA
VVRVATAVSGMPMATINLLDTASQVQLASQGFDRLVTPRAESLCDRALRVGGVFHAADLR
ADPRFTDSPWVDGRRDRVRGYAMVPLQLSDALVGTLCVQSREVHQLTDGQLERLADLGHV
VVALLERHRHSQETAGLARASEAARAELAAAHAELSAARAFDTALLESLPVAVAAVDAEG
RITAFNRVSRLWHGSDGDPTLTPQDLPQRYALRTVDGDLLPPEEVPLIRLLREGRLEDVQ
ITIAPDGLPARLVSCSGDAVRDPAGRLLGAVVTMVDITAQRQLEGRLRAAALHDPLTGLP
NRSLLVDRLQLALATAARSGDPLAVLYCDLDGFKAVNDGWGHAAGDAVLVEAAGRLSAAV
RPGDTVARIGGDEFVLVCPDVDGPAAAGLLAARVTDALTEPLHSGPGTTHAVGISVGVAL
SGPGATPETLLTAADEAMYRVKQGRRACR
>A0A7W3F142|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A7W3CYA2|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MSKPSQHVLVTLPHPLLRLASLGLVVFIFTLFSLELSRYGTQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGSIGASLLFFPTDTLNFTYTAINIIEAVAGAMLLRRLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGFLMWLLLPGETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRDPRLLLETLITLLVTLAFSWLSMMYLPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAANPSLLSTSKTFVMSSMPWLPFLMILLPANMMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLQMLSRGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKHT
EWINKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQIWYDCVV
PEDREHTENVIRDSLAARVPFKLEFRIAVKDGIRHIRSLANQVLNKDGEVERLLGINLDM
TEVKQLNEALYQEKERLHITLDSIGEAVICIDVDLNVTFMNPVAEKMSGWSQESALGISL
LTVLRITFGDNGPLMENIYSADMSRTAMEQEVVLHCRNGTSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLHTVHNSHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRTSDVLARLGGDEFGLLLPDCNIESARFI
AGRVINAINDYHFTWEGRLHRIGASAGITLIDDKNHVATEVISQADIACYAAKNSGRGRV
CVYEPQQNQMHAARGMLSPEEQRNIITHNPMLMIAHGVASPRIPETFSFWLLSLRLWSSE
GDVIEEQAFRASLVDPALNHALDRRVFTEFFQHSASAVAGKGLSVALPLSAAGLLNPVLV
DELLAWMENSPLPPRLLHLSVPGEVMKTHPAQAMPAMQRLRQAGCRIILSQVGRDLAVFD
NLKYHVADYLLLDSELSASAHGNLTDEMWVSIIQSHAQRLDIKTIAGPVNMPLIMDALSG
IGIDMIFGDIIADAQPLELLLNTSNFAIN
>A0A6C6YZU8|diguanylate cyclase|EC 2.7.7.65|Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLALETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A378ZWN9|diguanylate cyclase|EC 2.7.7.65|Pannonibacter phragmitetus|TrEMBL
MPGFPSPSADVSGLLDAWYDAPCALAVTDASFRLTRANRLFCRLAGIDETAAEGKRLSSF
LSRPGQIYFESILAPLLHIEGACSEVALSLQAASSSTPVLLNMTVRTGISPRLYDVAVFP
APERRSFEDQLLSLKSDAERRAAWLAQLEALSGIGAWTYEIRTGRMLWSGRTYELYGISS
GTDIDLETALRPFAPAVRRTIEDMLAQPDLPSLAPVSHEVEFSHPSGLVRRFKIAGHGSV
NHLGEPVIQGVLQDITDAYNSQLDLWRAAHFDQITSLGNRYHFNAELSGRTEPKGKAAEF
FLLIIDLDGFKAVNDTYGHRAGDDVLKEVSRRISLCASAGSFRLGGDEFALIVDAQSGVD
AVRALAQHLLTDIARPIDTGKEAVCVSASIGISHYPSDGCESDLLLHAADCAMYAAKKNG
KNQFAVFQPGAAAGI
>A0A7W3I659|diguanylate cyclase|EC 2.7.7.65|Citrobacter freundii|TrEMBL
MFPNAMNDENFYQKKVVPNEAFILLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVL
VSQPITGGWWLLLVGWAFVWPHLAWQLASKAVDPLHSEYTNLKADAILAGMWMGIMGINL
LPSTALLMIICINLMGAGGMRVFIAGAVLMVVSCLVTLQLTDIPVAFSSTQLGVLLSLPV
LVVYPLLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRHQR
DATLLIIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGT
SASSAIAAMSRVHERLTQLRLSCAPQVDLRISVGVAPLTSETEHYREWLKSADMALYKAK
NSGRNRTEAAA
>A0A514EMY2|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MNKDFSQAPRPTFKRALRRISVISVVISMTLVWLLLSTASVFTLKQYAQKNQALTAATMS
RSLEAALVFADSAAAEETLATLGKQGQFSEALVLDSQQNHFAVWRNTDLVRQEKLSGIIS
QWLFPEPTTQPIWHQGKVIGELRLTALDSLISHFLGISIIVLTGSILLASFIALLLTHSL
HHGIVAALQSITEVVHDIRENRHFSRRVPEERIEEFHLFAQDFNSLLGEMEDWQQQLQAK
NAQLLRTSLHDPLTGLANRAAFRNVISTLMKDETARRSSALLFLDGDNFKLINDNWGHAT
GDKVLIEVASRLMSFASKRHQAWRLGGDEFAILLRDVHSEAEVKALCVSLSGQFLKPFNL
HNGHTTTLSLSIGYALAWEHACAENLQEFADQNMYRMKHRRLAQGQK
>A0A514ETF8|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MLNSEKNININAQSSRSWMNLFPALLVIIAVSTLCVVISKPLASWDLIFTNAGLYIDLLA
LLFLVFMLWISAKVRMSHVAVNWVRNGLLLWIAGGTFDFMDEIFVQPRWMGYYCEDLLRL
SGMLMTTIGIYKIIERINVLYVDARSQSLKDELTQLPNRRFFIDTIREKQGHQLALMILD
IDFFKKINDTYGHLVGDEVLFALGKQLAKLTSDKILPSRIGGEEFAIIVDGMSAEEVREL
AQSILENVRSILINRDYPLSVSIGVGMREKDEPQDVFIKKVDEALYQAKHNGRGRVEWAA
S
>A0A250AYY7|diguanylate cyclase|EC 2.7.7.65|Gibbsiella quercinecans|TrEMBL
MQKEIEQYISVILQEWQPLRAELPQAANVVLQQIAEEQSDDLANKFYESLFKDPAIARHL
SYELVQERLSRSLSKWVKAVLTHGENQLEALAQQQYHVGGVHARIGIPVEFVQRGARQLK
YGIFDYVTSRSLDPALSLQVMHYAAMAIDIAIEMMSHAYAMSHYLATRNEESYRLHVLMN
NAHLEQGKQQTALSNWENSVIYSLVSGARQTEPLVNISESSYGLWFRHKCVRHFGENQQV
QQMRQLMTQIDEKVDSIDTTAEMPVKKMQELLRVIHSSCQQINTHMEMLFNEASHMQDGK
DALTNLLNKRYLPIVLKHEVSLAMENHLPLSVAIIDVDHFKKVNDEWGHTVGDRALTHIA
NLLSDNIRSSDYLFRYGGEEFLIVLVEAGQSETYTLLERIRRIINSTPFEGVAGKTLPIT
VSIGYAQHNGLPDYNLLLNKADIALYEAKRNGRNRIEPQ
>A0A514EQH6|diguanylate cyclase|EC 2.7.7.65|Raoultella electrica|TrEMBL
MLKNFPDEKYISDRNASFIKRVYLLRQVGVILCFIPIYSVLEEQSHHKITIALLILNALT
WPSIAYIASIMSKDMLNTEKKNMILDSCWAGMWIAVMQVSPIPSIFIVSIQIADRYAAGG
WRILKPALLCMLLSFTLIWLLNDFNYTTEFSTRTVWFSLPLVTCYPILLSVVSRRLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMEGAFRATRKKRILSYLLLIDVDNFKYINDTY
GHEVGDAVLSRISTILRECAGAQDIPARFGGDELAVIVNNSNDQLVLAMVHAIQERIEVL
SLPSHKDISCTVSIGISCAKNKTSIISWIKEADEMLYEVKRNGKNGFCMKSNKK
>A0A6N2T0C5|diguanylate cyclase|EC 2.7.7.65|Anaerostipes caccae|TrEMBL
MIQTELFLLLIGVSAAQEILRVKAMESVGYLWKEHKSALIFCGAASLVWSGVTVLSEVPV
YLSLLLYFLLWYLPYLRVHINGKMIQTFSMIGYLHLSSFYLMFLGAASIGRGSVRNINLQ
SSVKASGYLTAKIVLCIFYIIWIRYFSGKNVKEEHTDYKKSKIFLLFLWSCLVYEMIDSI
LASFFSDNVFVPALMISGNALILLLTFLFMRHNYLIVREQYLEERYRKMEEAKARKLLRE
EQMTRMAKTDSLTGAYVRGYGIELLKSFLKQNKLLTAVYMDLDGLKEINDSKGHSVGDVY
LKTFAEEMKKNLKKDELLIRIGGDEFLAVFPGIGSEETKDKMEKIRKEMEHPEKDRLPIH
FSFGAVSGQKTPEELIKEADQAMYSDKHNRKEERDTVCPNN
>A0A518ATB5|diguanylate cyclase|EC 2.7.7.65|Aeoliella mucimassa|TrEMBL
MPPFAFPYQPVSNDHRSEPLHDTYHSQAFSTTSTFSRRCQVLIADDDPISRSVLANICSY
IGAHCEVAASYEEATWKLSCQEFDFAVLDLNMPPHNGLEVLRVIRQHYSEAVLPVVIVTS
DSDRQSAIAAFELGANDYITKPFDSATAIARIRTHLRMQQMQRQLSESILRYQLAMQGTN
DGMWDWDLLGDCMYFSPRWQAMLGLEEREHFGAPNHWFNRIHEDDRDQIFQGLKAHLNGE
TTHFDSELRMHHANEEYRWMLCRGKAVFDANGRATRMAGSLTDVTEGKSVDALTGLPNRA
LFLERVMRRFAQFQRDTSRTFAIVYIDVDDFKLVNDNFGHAAGDSILASLTYNVQANIRR
PDSVIARLGGDEFAILIEDLNCRQAGYVIADRLSKAIASPCSLPGEVSFTPSASIGVAFA
DATMNSFHDLLDSADQAMYQAKRSGKNSYHISEPAASGPPQVDRDMLPTPRPTWHKPLG
>A0A8F7LJ02|diguanylate cyclase|EC 2.7.7.65|Comamonas aquatica|TrEMBL
MHSPDERPTTALDDQGLASGTTHLAGQGIQNIRVMVVDDQNSVRLALAYELQRSGVTEVI
QAADAESAVALFQQHRPDLVLLDIRLPGKSGYWVARRIRESENGDWTPIIFLSGLDNDLD
VWQGIESGGDDYLVKPVKPIVLMAKLRAMQRLLDMRRRLVSMSAELRLANQRLNHMVEID
ALTGLTNRRGLERLLHSEIHAARREQQPLTLMLCDIDFFKSYNDNLGHLAGDECLREVAR
LLRDVCVRPRDIATRYGGEEFALVLPNTPRSGAMTFARALCSVLHKRAIAHPQSAASPFV
TLSGGITTCIPDENTDEESLIMRADHALYAAKAEGRNRFFSFEMQMDTIEQLRMR
>A0A2P7ZT45|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. 111WW2|TrEMBL
METDSEPYVRLASLRQLHQAMADMNKARSLADTLQAVADGVVQALNYELACVNLVGPDGD
LVVAAFAGNPAAEALITGRSGSRESWDRRLGMGEQWGDLIFIPHTEGWVLDDDDVPQWYT
DGPAPRFEDEWHPSDRLFAPMYAPGPQGGGNSGELIGVLSVDRPRNGRRPGAWGREALQM
YAFQAAIAISNARLRSNMQRALVRLERDQQALRASEESFRQAFEYAPSGMAIAEMGGDQH
GRILRTNDALCRLLGRRASSMRRYAFSDLVHPEDIGTLLRTSAEGGRAELRLGRRDGTYV
WVSLRNSVVADAADGPRFLLTHVEDIEERKRRELHLAHRASHDSLTGLPNSAELRSRLAA
RLCQRPQSSHAVADAMDAAYGNSAVFDSGGHTFDFSVAAEPYGAFDHHVHAVAPEDGRDD
GTKGLAVLFCDLDGFKSINDRFGHNAGDAVLIEVARRLSGGVRDGDTVARLGGDEFVILA
NGLGRADAQDLAVRLRGEIIQPIRAEGRAVRVGASFGIGWAHCGMTADEVLKSADERMYV
EKRSRPKQHRRAG
>A0A173S758|diguanylate cyclase|EC 2.7.7.65|Anaerostipes hadrus|TrEMBL
MKQNKWKHLKFEKYVFVLLLAIELIMSFTFLGFIHIDPISLTTAYIPIVVAGCLLGPLES
TLIGLVFGLASMYKASALYVVSDDKIFSPLYSGNPIGSILLSVGSRVLFGFVIGYLFSII
KGRKYEKIGIWILSLISQWIHAFLVFTVMGACFPQLGYTGMSTFHMGINDALIALCCLFW
VEVAYKIYHKERIQKYKDAVNQSLDDPYLSSKIVAISSGISFLIICIAIFSTGYFANRST
YMLKQHRVHVTRTIEIDLLHLQVQFLIAMLALDFILILTMLMIYQYMKYREYQGEIDFLT
GVMGRRLFLQHCQNIQSDQRIHGHQGWFLFLDVDWFKQINDKLGHIAGDETLKQFATFLQ
EQFEPYGAVGRVGGDEFAVMIEEEMSQEALEEEMKQFFQNISGIQKEVTVSCSIGVYRFT
YPKTIKELLTKTDEILYEAKANGRGCFVIR
>A0A0Q0JGY4|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MNPNAVHAKELYLSDKHNKPIGLSLKQYIEDERLNASQAYSLLQQGQFSPVSQHISNYGI
NAKPVWLSLTLINNSQTEQEKTIHIDNYWLDEVSSFWFADDHIIHFEHQGDLSLFYQQES
QQPSFNFNYRYPPGKTTVLIRVQTPDAMVIPVYLFDQQEMAKKNAFNAYSYGFLYGSITA
LLIYNFILYVGLRLKSYLFYSLYLLNFLLLNFAYSGHGSLWLWPDSPIWQQWSIPILMVS
FCTSGIMFACHFLRLKFQLPTLNKILKSLCIIFPALMLLAAVLQDRVLGLIFAFDLMLLF
SGLMIVLGILSLNFGNISARFFLIASISSMIGIAITCLAVWAYIPFNQFTYRAAELGVFI
DVLLLALALTERFRRVENEKTIAEKMANMDPLTRLNNRRAFYQLVEPQFTERQVKKAASI
LMVDIDRFKSINDTYGHNFGDEVLVKVAALIRDTLRKNDILARWGGEEFIIFLPYTQEQE
ASTLATRLCENIAKLSFTQSQQKVNVTASIGIVTSCSAINQLPMLIEIADKHLYQAKRAG
RNQISAGTSPSKERIDKLAT
>A0A0Q0HIR2|diguanylate cyclase|EC 2.7.7.65|Shewanella sp. P1-14-1|TrEMBL
MLTAPIPENDAARLATLRNLNVLDTAAEERFDRITRLAKRLFSVSICLVSLIDENRQWFK
SCQGLVANETPRDISFCGHAIQYSEAFVITDASKDARFSDNPLVTQAPHIRFYAGHPLTM
PNGMRVGTLCIIDDKPKELDKDEMLALQDLAEMVVSELISIQQTTLDQLTGISNRRGFEV
LAKQALSTWDRNHIDSCLVFFDLDYFKEINDNHGHEAGDRALNQFAQLLTSEFRDSDVIA
RFGGDEFLVLFSECSKGQVDVALARFQTALNAHNSQSEDVFELAYSVGVATRHANQKLDI
AEYLEIADREMYQVKSKHHQQR
>A0A2K9K4L4|diguanylate cyclase|EC 2.7.7.65|Pseudoalteromonas sp. NC201|TrEMBL
MTKYGLIVRLALVLVVSTFIFSMLYAKLYHDHIVERELRRSNTIIGQIGQTVSSSSSIAT
YLNDKDLAVEVINGLVSNDVISSAAIKSEDKWLAQSVGFKSQNATIISLNHPFLLSEIVG
EIYIQPNSVFIEQSARDIARSSVQTLLVVIIPILVIFTVVTHFIVTKPLSNLSSQIARVI
PGTPLDLVVPRGHESSEIGDIASNTNQLIAKTASMFEQERQLRADIEILEKRFRLMFERS
SSPTLLVKDKGEVILANDAACDLLAGMAIDLDEYFPESFGRYCKTPDILYTFTEHTLELN
QPTQSEFEFINPMTEQPVWLSVIMLRVESSGQFYLQVFLSDITLRKTVFQELNKKANRDK
LTGLYNRHGTEIKINEWLDNETPFSLFIIDLDEFKPINDIYGHNAGDAMLKHIATQISAQ
VREQDVVCRWGGDEFLIALHCAKNEKLQRIAENLLGAINTEMIWQTSEGKLLPLRVGASI
GIASYPRDAVELSQLIECADVAMYTVKKDKKNAFQFYSLSA
>A0A749KSJ9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGPFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>D7XVW4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli MS 84-1|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYITKRRGRNRVELWKASL
>A0A765IW11|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSPLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A612U748|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVIILKDAYVASQRNHL
GSIANALDRQLQFNMDRLLFLRNGMHEALVVPLTFSALQSAVTQFEQRRARRFWQLELDK
RRTLPLYGVSDHFVARTTLLSRDNRDLANELTATLELGYLARLARLARSSAMLTLEIMYV
SRSGFYLSTLPTAYGSDIVFRYSQYVTQPWFIEQSQRRNPPRGVRWFTSAQPYFADGQQK
MTASLPLDHDNYWYGVLAMDIPIASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQ
TANTLNDRERALLAHEMEKDTLGGLRLGTRYVSWERLDHFDGILLRVHTFREGIQGNFGS
ISIALTLLWGLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKAS
RLAKRYRESRKPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVG
GEEFCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFE
QLQSLADKRLYYAKQSGRNRICVSDATQEREKK
>A0A5V0Q272|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLSQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRQLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>W8UXU8|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30684/NJST258_2|TrEMBL
MDKPLRLKLKKCYHLARPAHVVNACFIAVLFFSTLLIWREINVLEEAYVANQRNNLANVA
HEMDGLLQFNIDRMMFFRHGMQAALEQPLDIDVLRKASQRYLSQRHQQAWRVALPNRRTL
PVFGISGSVAGDNPILLVDDPLAADELMATLELGYLLNLTQHDRDFAERMQYISRSGFFT
STLPLRDESQVITHYSQALSAPWFTRQTQRNNPGRGVIWQIFPDDDPQLEEQVVTASIPL
DFAGYWRGVLAMDFSVSEIKAFLVSAMQGGQVGEYQLYDSHLNLLASSAPGNVLTLLSPR
EQELLSRAFVHDNQGGLRLLTRYISWAKLRNFDGVLLRIHTLREGVRGNFGTITIALTLM
WVLFTLMLLLSWLVIRRMVRNMSVLQTSLEWQAWHDALTRLLNRGALFEQAMAVASDCQR
SGRPLAVIQLDLDHFKHINDRYGHQAGDRVLSMVASTLSSAVRQGDLLGRVGGEEFCIVM
PNTTLQEAAAVAERLRQRIQGREVFLHNNVTLRVSASLGVSASEERGEYQFEALQSVADG
RLYLAKQNGRNQVCFRSAA
>W8UKF9|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae 30684/NJST258_2|TrEMBL
MLTNKRERARQQRAALWATRDNVQRHALSMSMPWLAFVNIAFALMIFFRNFIFTYFDKRL
LTHRAVIPYIEAALIAVIIISAILVIIALTPRLAQGRYTLNIITGLLLALSLCWSLSNYC
FIFFWTLPFAWPLLVILMTTGLTALYHHWPGITAFMLPLWVTALLAGIQLHYHTEIRFLI
LWAIFTAILLYGRRILQRWYDEAWDTHQENMQLIQRLESIANQDALTGTANRRALNAYLA
AIWQQKTPLALMMIDVDYFKRYNDRYGHQAGDECLSSVAQVLKMAVRAEGDLVARYGGEE
FVVVLPGVSLAHATAIAERIQQKIREAGLPHAASAVASEVTVSIGIVASDGTVPIETLIA
RADRALYQAKNKGRNQWSY
>A0A5Y8LL90|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDHHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5V2R106|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNEENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLAGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A746PP17|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGAHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A744JQ75|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDYDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A742YUD9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRSVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A522X4B1|diguanylate cyclase|EC 2.7.7.65|Gallionella sp|TrEMBL
MAFYDVTRDEMQGILAQLEQALYNHQQWHAALIRTLVCQLPGDQHDISPGAHLECRFGQW
YYGNVPGRLRDHAGFIALGAAHQHMHQLAASLLVSTRAGKQVTSFDYDNFANALDRMRLE
ISALERELEDSLYNHDSLTGAINRYGILPALREQQELIKRGTHLCCIAMMDLDKFKAVND
LYGHLAGDQVLISLVHYLIEHLRPYDKVFRYGGEELLLFMPHTELTPGYNMLERLREGLA
AMPIDIGGKEPIHITASFGLVLLDADIPVEASIDHADKAMYAAKSAGRNCVRVWDTAYSG
GCAPEENGRTALPDQDNVSCAQPAD
>A0A378EAX3|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MTGLANRAAFRNALAELMQNEVDHQTSALLFLDGGNFKLINDNWGHAAGDKVLMEVASRL
MTFAGKRHLAWRLGGDEFAVLLREVRSEAEVQALCQALTEQFLPPFNLHNGHSATLSLSV
GYALAWEHATAESLQELADQNMYRMKNQRIQQTLK
>A0A157NYV0|diguanylate cyclase|EC 2.7.7.65|Bordetella trematum|TrEMBL
MIQNLSTTQVLTLGSPAIAIVISGTFFCLWKFHDRRSYLILLASAFLLYATGAAMQILRW
PADPGLNNIVSTAAMLASITSLAAGLAVRYGRRAKRWLILAMAGIWLVNSYFCYASPEPA
LRSYALNFGIGLVLCAVAWRIRHALRGSLIDRGIFWILLLFGLSFFGRPLLTQALPAYLI
VPDWLGSQAFDLILQVSLVLMGLVLALLLFAASVADMFTRMRNDRDIDGLTGLWNRRAFD
ERLEALITRAPRQPYTLLLIDIDHFKSFNDRYGHAVGDTVLRLMGRLIRDCAGDQALTGR
VGGEEFAVVVPAEPAEAHELALCLSRALHDSKIPDIHEDHQITASTGLTMLQTGDTVSIW
MRRADILLYQAKHGGRNRIVRQASTT
>A0A378EAZ0|diguanylate cyclase|EC 2.7.7.65|Klebsiella pneumoniae subsp. rhinoscleromatis|TrEMBL
MQNGKDALTSLLNRRYLPVVLKHEVTLAIEYDLPLTVAIIDIDFFKEINDKWGHMVGDRA
IKHVADLLSDNIRSSDYLFRYGGEEFLLVLVETRAAEAFPLLERLRKKIGQLAFNVGGDT
PDPHHRQHWLCRPHRSPRLQPAAARRR
>A0A8A6KLR0|diguanylate cyclase|EC 2.7.7.65|Streptomyces sp. AgN23|TrEMBL
METESEPYIRLATLRQLHQVVADLNTARSLADTLQAVADGVIAGLGFDLSAVNLVRPDGD
LVVAAVGGSAGAEALMAGRVGSRCSWERRLSMGDRWGDLRFIPYSEGWVLDDDDVPQWHT
SGPAPRFPDEWHPMDRLFAPLYAAGASGGELIGVISVDKPRNGRRPGAWGREALQVYAFH
AAVAIGNARLRGNMQRALLRLEREQQALRASEESFRQAFEYAPSGMAIAEMGGDQHGRLL
RTNDALCRLLGRPASAMRRFSFSDLVHPEDIGTLLRTSAEGGRAELRLARRDGSYVWVSL
RNSVVADAADGPRFLLTHVEDIEERKRHELQLAHRASHDSLTGLPNSAELRARLAARLCA
TPPRPGGGYDEEAASLGGAGAGGVYVDAAGHLHGFDDFECFGTPPPAESVPFDGHVHTIP
PNEDSNADDGHKGLAVLFCDLDGFKSINDRFGHHAGDAVLIEVARRLTNGVREGDTVARL
GGDEFVVLADGLGRADAQDLGVRLRNAITPPIRVDGRAVRVGASFGIGWAGCGMSAEEVL
HSADQRMYIEKRSRSKERRRAG
>A0A1B7HTX7|diguanylate cyclase|EC 2.7.7.65|Buttiauxella noackiae ATCC 51607|TrEMBL
MFGNAIQRVISRFKNPQKVVNLCFIFVFLFSTVLTWREAVVLEGAYVANQRNSLDSVATL
LDRQLQHSIDNLLFYRNAMLYALQSPISTDRTRKSLADFDTLRSQPFWQLRLDLNRSLPM
SGVSDEFVHESPLLDRDEKTLHSELSSALELSYIMRLSDRSGTMPQRMFYASRSGFFLTN
TPPANDPGIVSLYYRLIARPYFSSQSQQNNPQRALKWTHTFNPDTASGQIVTASVPLDFN
GRWYGVLALDYPINSLHSFLQQAKYDDHEGTVLLYDNELNPIASSLGELPTHSLFTAPQL
AQIANVVTSAKQGAQGEIRMDSRFITWAKLSNFDGLLIKVHTLEEGVQGEFGRISIVLSV
LWLLFTLMLFASWIVIRHLVTNMFSLQQTLSWRANYDTLTRLYNRGAFFEMARKLSQECE
QQGLPFSVIQMDLDLFKSINDRFGHSSGDKVLIHAAAMLSDAFRTGDIAGRVGGEEFCIV
LPDTSLEEATKVAERIRVRINSKELLLKQGNTVRISASFGVSSAAEFSDYDFERLQTYAD
HRLYKAKQGGRNQVCNHD
>A0A0T9KHZ6|diguanylate cyclase|EC 2.7.7.65|Yersinia nurmii|TrEMBL
MSLYSRANSRQAGLSFARRIYLPRIFGLGIGMLCVLSVLITRQTPLWMWALLAINGLIWP
HLAYQLSIRANSPHRQEMLNLSMDSILGGVWVAVMSFNALPSVVILSMMSMNNIASGGKS
FFLKGLGLQIIGCLLVAWIFRLPFQPQTTPIQVYSCLPMIFIYPSLLGWVTYRTAKRLAD
NKEELLRISVRDGLTGLYNRRHWEHQLHNQFDSCRRYKHSASLVLLDIDKFKNINDTFGH
AVGDDAITALAEELLLGLRAVDIVGRYGGDEFGAILPNTSAEQACEVLGRIQEKLAEIVF
NQSPGLQIKVSAGVSEFKPEMTNYQQWLKAADSALYHAKDNGRDRIELAS
>A0A0J1FE22|diguanylate cyclase|EC 2.7.7.65|Peptococcaceae bacterium CEB3|TrEMBL
MLPAPNPIGCENKIREVLGTGSATVCLADADGLKGINDKYGHLAGNEYLEHVLDELRGCF
PEFIWDRYGGDEFIGVSPDRIVLTPEQAKRETVEIFNQSIKIGYSLGVVYTAPNDTAELA
LAMADAAMYEAKHVHHGGLLMFEPQKRVGLIQTDWPADWYVPLVRGKIRFFLGYEQGGVD
FVFTRDPDILEGIFVESADQLCHCIKHEPAESDDQDEFGEWGMPIENLEWRTKVPESEWE
QIEDDQPVRIRLERDGRATAKPEAPKPPIPKFSAKRQRHKISIPIPKIPIPKIEKPEQPG
TPPPVPSDSGDGGAFQGKIIWIWGERGHEVDYAFAQYLARFGPVLYLDGDLANPQQPGNW
SDCWALGTPALAPSGTKQEGNLWVWGLGKRPPRPKNAKALWENALYSLNTVDRAIVVGAG
KTAPPPYVDRIVFVTEDNGLTLNYPAIAISPLDKPGDILRLLPRKAGER
>A0A658IJM6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Newport str. CFSAN000835|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A8G0SCF4|diguanylate cyclase|EC 2.7.7.65|Bacillus inaquosorum|TrEMBL
MLKELFVNLTILITFNYLFTHLFKDRLVHKKDSVSFQAVKGLACGFLGVILMVFGFTYQH
SIIDFRNIPIMIAALYGGWVSTATALVMIGAGRMLITMNTSALYSVIIICIAAIPSLIVS
RRKKVQLKHAFYLLMITNSMISFSFYFLIDLHSYELHFYFWIISIAGGMLSLYIIDHETN
AHLLFKQYKFQAHFDFLTGIYNRRKFEEITQTLYQQAANTPHFQFALIYMDIDHFKTIND
QYGHHEGDQVLKELASRLKHSIRNTDPAARIGGEEFAVLLPNCTLNKAVQIAERIRRAVN
DEPVRLTNGEELSVTISLGAAHYPNNTEHPESLPILADQMLYKAKETGRNKVCFSEKKE
>A0A509D1G4|diguanylate cyclase|EC 2.7.7.65|Salmonella sp. NCTC 7297|TrEMBL
MHRWTFLQKGTMGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVM
VDVNQDNLKNIFYTQDRPLVWRYLNVTLKDLDSGKEIIINQSKNNLFQYVNYNHDIPGGL
RVSLSLDLTYFLVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKI
LTPMLEQRLQRLVNAGTPVTFVAIDCDRLKLINDTLGHQEGDRIITLLAKAIKTSIRKSD
YAIRLGGDEFCIILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDA
YQASDAQLYLNKQQKQHRSS
>A0A1Z5H5Z6|diguanylate cyclase|EC 2.7.7.65|Bathymodiolus platifrons methanotrophic gill symbiont|TrEMBL
MGNFSLLYADNYKNHKAIEPKIINYIAPIIHELGIALANAQCFIQEKNRAELDSLTGLSN
SRMLTKFLNDAFLLNIHQLSHIAVGFIDIDFFKQFNDTCGHQVGDEALIMVAQIMRSLTR
PSDFIGRYGGDEFVFVLQSTDKKGVYSYAERIRLEVEQQGKILSRQFLGHEITISIGVSL
YHQEYNSSDKIISAADTAMYRAKQKGRNCVVIV
>A0A2S0XMF1|diguanylate cyclase|EC 2.7.7.65|Aminobacter sp. MSH1|TrEMBL
MLDFGSLLLATALSGACLSGTLLAIWLTARQARFVFTMAAGILLLVVHVIGFWQYGRNAS
PWLGQLTLTLLVAGFFVILCSTAQYLDKGWHRIAAAPVLAAVVLITAVTASGYDGLGFVL
AYSTVTALLIVVTVMFWAAGAYDRRILAAVTLLAGSAAVSFTLCALVLVLDGQWSLGTVP
KNWAEDLNTAVVVACMTALGALTISLHHLRTQRELTVQTLTDPLTGLLNRRALTIFHGDT
RFGSTTALAMFDLDHFKRTNDVFGHAAGDTVLQRFADVVRNHAQDGVECFRLGGEEFAVI
MSGVAPDEAHGILRSIGGSFGAEIVVTRLGPLRSTVSVGICFGDDGAMTLDEMLTAADAA
LYAAKRAGRNRAVTADMTGGATTYEPARLFA
>H1WK28|diguanylate cyclase|EC 2.7.7.65|Limnospira indica PCC 8005|TrEMBL
MELIAQCVVNCFQPENFLILIVDDVSKNLQVVGAMLDDVGYATTFATSGKQAIERVKTAN
PDLILLDLMMPEINGLQVCEHLKADPLYAEIPIIFLTASNESEHLLQAFSQGAVDYVTKP
YKAPELLARVKTHLELKYTRDELKQALVELEKLATTDPLTGIANRRHLLTLAEREFQRTH
RYNNPFSVLMIDIDHFKLINDNYGHNIGDEALKIMADVTVNALRKVDIFGRFGGEEFVVF
LPETQADEALLVAERIREAIATTPIYVDDQTIHITVSIGVTIYESSEMSLDGLLMEADKA
LYDAKKQGRNQVVIYTKFNQVN
>A0A5M9J0X2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas extremaustralis|TrEMBL
MPAAGGKGLPLATRLYKSRTLGLTLGFVCVAFGMYPVNPPLWVWAWMILNAFVWPHLAFQ
STLRAPHALRSERRNLLFDSFCGGFWVGAMHFNPLPSVTTLSMMTMNNVAIGGPRFMLAG
WVAQGLGIGVSLLIFTPAFIALTTPAQLYACLPILMLYPLALGWICYRQALNLARHKREL
LALSRTDSLSGLLNHGAWKDHLEIEFQRCRREQQGAAIALIDIDHFKVINDTYGHVTGDI
VLRQLGKVLRQNLRAADLAGRYGGDEFCVILPGMPLNRATEVMDALRDRFNALAYAQDPT
LRASLSIGLAPYQLTHADSTSWLNDADLALYEAKSSGRNCVSAVQGAWLRSV
>A0A8F9T968|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. So3.2b|TrEMBL
MENLRGKGLSFARRIYRPRILGLGIGSLCVLAALYPLAMPGWVWALWLFNGFIWPHLAYQ
LSSHSAFPYQAERRNLLYDSVSGGFWAAATQFTPLTAVTILAMMTMHNVAAGGKKLMIQG
MLAQLVGVAVAWLVFGPSFNPNVGLIQVYACLPMLILYPVAIGMASYRLAIKLSEHKRAL
SALSRTDSLTGLLNHGSWKDLLQLKFHKCQQQQSQATIALIDVDHFKQINDAYGHIVGDR
VLRQLSKELQRNVRENDLTGRYGGDEFCVILPDVSLEQASYVMERLRELFSRYRDPQVPE
LRVSLSIGLAAYQVQFTQAHMWLNAADQALYAAKGTGRNRVTVADSLVARSA
>A0A0N0XI70|diguanylate cyclase|EC 2.7.7.65|Amantichitinum ursilacus|TrEMBL
MAEVIRLARLNQLNVLDSAPEALFDTVTRLAAEICGMPISLISLVDKERQWFKSTYGLEG
VSETARDISFCAHAIEHGGVFEINDATQDPRFADNELVTGPLGFRFYAGAPITLRDGARP
GTLCVIDQTPRQLTDSQRHILQCLAQIVSDCLQERERCVSLSRDLMDSEDRYRAIVDFSS
DAIISKSLDGIIHHWNLAAEKLFGYTAQEAVGQHISMLFPTDGVQEECMLIRHVLQHGSI
SQFETVRLHKDGRRLDVAITLSAIRDAHGRVIGVSKIARDVGERKRLDQELNRSLTRHQM
LYHIAPAMMHTMDAEARLITVSDTWLAHMGYAREEVIGRHTWEFLTPASRIKAREQVIPG
LFENGRCDDVHYQYQRKDGGVIDVLLSARLERDVEGKAWHSLAIMQDVTEKKRFERELAE
QNERLRVTLQCIGDGVITTDVDGKICYMNPVAERLTGWSNGDAIGQHLSQLFKLTAEHSK
PYALPGVPREGTVLIARDGAEYDIEENMAPLLNDQQESIGMVLVFRDVTRQRQMTSEMTY
RAAHDPLTGLLNRGEFDMRLHRALHEAKAGEGEHVALYIDLDQFKVVNDACGHSVGDQLL
RQVSSMLQSCVRTTDTLARLGGDEFGVILQYCAVDKALRIAEQMVELIDQFRFMHDEQRF
RIGASIGLVRVDASWASAAAVIHAADTACYTAKEAGRNRVQMWLESDESLHSRQVETHWA
ARLEQAIDEDHFELYAQRLTPLSTPTGALYCEVLLRLREPDGSIVPPGAFLPAAERFHMA
SRIDRWVVRKVCEAMASADLSLVDTLSVNLSGQSIGDRAFHRFVVDYLDRNQVDTSKLCF
EITETTAITNMREANDFIAAMQARGIRFALDDFGSGAASFGYLKSLAVDVLKIDGQFIKE
LASDAVDQATVRCIREIASAVGKATVAEFVETAETASMLRDMGIDYAQGYLYHRPEPLGQ
LLR
>A0A0F0C716|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. FS41|TrEMBL
MKIMGKWNKRFGYTAVFLAVNLIAILLLGKKESFYIQNAMAAHGEENIRQINGVMNNYIH
SFQLFSHMMARETEDNRDPDDVLDYLKSIDSEMLDIEGDTFDGLYMYYQGRYLYSWDTPY
SEYESTGYTATERPWYKDAAAGKGDIVFTPPYMSYANHYILSTISQLQPDQQTVFAYDIK
MGNIQNLVSSLVSYDREQMMIFDDNGTVIGSTNSDYLGGNLWDSLEDIKASIEETRASIE
ETGASIAETGASPEETKAGPEQEHTPAAAGSLSDAQTEKLKEQIQSAEAFLSFRKGIDAG
LSNLLDQTSTVLTVKSGNSTYFGYLQPGNGYHSLTLVPVASMLKSSVQIWLVPLLLMELL
LFYILGRISKDRKSRELKAAYIELGQTQRRLELALSVAQKAAAIDDLTGMMNFKSFRKNV
AEYLNSMEKDESGILIMLDGDRFKAINDNYGHSVGDEVIKLSAQMIVGRIRTIDLASRLH
GDEFAIFVSKTEDYSVAKRIIDDINHTIAAEASRRNMPPITLSAGAVTARQGDSYSQLIK
AADAALYRAKATHNGGFSYAPPA
>V6F3E5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MEIISIQTEIAKLGLDLPNVMQLVTDRTLSLIGADGAAIELAEGDEMVYRATAGSAQSQI
GLRIKRDNSLSGLAVREGETLLSADCETDHRVDINACRKVGLRSMIVMPLHHNGATVGVL
KAMSAHPAAFRDQDVKLLNLLSEVVGAAMFFATKYNADDLFYQATHDSLTGLANRALFMD
RLRTLTSQHAREQKAAGILMIDLNGLKQVNDSFGHRAGDAMIKEAANRLKQVARQSDTVA
RLGGDEFGAILSPVEMENGIQAVIDRITAETASPFQFENRTFQLSASIGAAHFPDESVEI
EHLIELADQRMYEVKRRHHDRTRPEIH
>A0A3A5JLY6|diguanylate cyclase|EC 2.7.7.65|Buttiauxella izardii|TrEMBL
MVHTLRVIHLCFIFVFVLTTVLFWQQGQLFSQGYRTSQLSQLESVIARIESRAQYKMDSL
RYLKQIFTEAMDDPMFPGSANAPWEANSNVLQSPLWIGELPLPESVTAGEAFPLHDPLEV
RQEMNALRKIQGLFPLATRGSELFADLYYISREGQFIVSLSQQVNTLLINSYNPHEKQGS
FVLASPLLNPQRSTFWTRQNIAQSNDTLINGAIPVDFRGEWIGLLGMAFSNESVQRFITA
SLPEGSQNAYQLFDEQLNPLTTVVGAENGFRLNAQQIATIRKMLADKPRGTLRSGPVFIT
FGEMRDTRSVLVSTQSLSQGLHEEFGRFSILLVTMWIIFVLFLLASHRVICRLVHNMGGL
QREMQHHALHDELTGALNRRGFFAKTSQISPDYIDYTVVQLDLDHFKKVNDVYGHLVGDN
VLVHATRRIQRAIRSQDILGRIGGEEFCIYLPNSDLKAGIMVATRIKWELQSAPMMLEDG
SQLPVTASLGVASHSEYPEYTLDQIQALADMRMYRAKESGRNQVCWQDEASRQV
>V6F1C5|diguanylate cyclase|EC 2.7.7.65|Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1)|TrEMBL
MVLRYAAILLGVWTLLIGGSAWLNLDRQTALTGDLAVGSARSAFNKDLAYRQWASSHGGV
YVIPDERTPPSPWMSHLPDRDLTTTDGRTLTLMNPAYMLRQMMQDYDSMYGIKGRIVGEV
YLNPENKADPWEAQAIRAFTDGTAKEIIERATIDGAPYLRLIAPFIMQESCQKCHGHLGL
ANGTVRGAVSVSVPLQPFLAAEKKALGAIVVTHALVWLVGLAALVFVTRRTLARLEEQAR
VEDENRLAEHVFANALEALVVTTGDGTIVRINPAFTKLTGYQPDEVIGHKANVLRSYHHD
DDFYAQMWQSLLSTGSWQGELKNRRKDGSIFVARENIAALMEPGRDRPRYYVASFTDITA
QVESQQHIEHLAHYDPLTDLPNRALFRDRLGHAVTLANRERRKIAVLFLDLDGFKKVNDT
IGHRAGDSLLVEVARRLKACTRSSDTICRLGGDEFALVLERLDEINDVVPVADKILTSLA
APFILEGREVYVGSSIGISLHPIDGNDAETLLKHADTAMYQAKAEGKGRYKFYAADMTLR
QERRLDMEGALRGAIDSRAFHVYYQPKLQLRGGDIAGFEALVRWDHPSLGLIPPMDFIPL
AEELGLITQIDLLVLEQACTMGVQCLARGYPVTMAVNLSSLDLKNPDLPTLVAGILAQTG
LPANMLVLEITESFAMEAGLGQTSILEQLTALGVSLAIDDFGTGYSSLSYLKALPVNSVK
IDRSFVRDIGTDSRDTMLVSTIVGLAHSLNLRVVAEGVEDHGQKDLLHHHHCDEAQGYLV
ARPMPADQVFAFLEQSAQDLAVAVAQ
>A0A0M7DJZ5|diguanylate cyclase|EC 2.7.7.65|Achromobacter sp|TrEMBL
MRYPHIPWLPLLFYPALPVIAAVGLLLWRQWPPALTLIVPFVPWVMALVGAAICLMYQRS
QTLALMLGVLTAVAIWPMLASEAPWALGPALVWWSLAYTINALWPERAGMLWDLAARIGL
MAVGAAAITLAGKDGVGQWFGTLAVQGMLGRLGIPAEALAALLVTGLTLTLLLLRYGRPQ
QAGQWLGFVCMAWALPRGGAHPIELAVMASAALTSLSISLAHEGYHMAFRDELTGLPGRR
ALNERLQRMGRVYTLAMADVDHFKAFNDTHGHDVGDQVLRMVAAQLRRVSGGGYAYRYGG
EEFTLVFPGKTAIEAMPHLETVRRAIEAYQMRLRDKPARPKADQVGLRRRGGRGRNARPL
RVTVSIGVAERGETLRAPDAVIKAADQALYKAKDGGRNQVWAYGSRRRAGAA
>W6M5W3|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MSEYRKGSNRQAESRSDRLGSITQIIGRPWALAVMALLGCWWLSVAVGAQPITPNDAGDR
FYWGYFVGGGLLLAGLFGIPVVMLAGQRRQLMLERERLSDRLFALTTRQQELEAEIERQR
QGAARQRGLEIEIEQLRRAGREFEAEIERLRQRTARQRELEAETQRLRQGTTRQRELEIE
VEQLRQNLAGKQKLEAETERLRQDLACHWELEVEVEQLRKEAASQRQLEEEIRRLRQNLE
TLRDSEQRFRTLTQQLPVGIFMADLQGQCRYVNERWCQMTGLAAEQTVGLPWTHALHPDD
RDQVEKIWRQALDKGSEFVVDHRFKTPTGRDVWMDTRAVPLRDRSGQIVYYLGANTDIAE
LKRTEETLRASEARFRSYFELPLVGIALTGPDKRWWEVNNRLCEMLGYRRSQLLQLTWAE
LTYPEDLATDLAQFERVASRRIDGYSVDKRFMRQDGSLLYASVSTRCIRRSNGMVDYYVA
LIQDISERKQAEEHIQHLAHYDALTDLPNRTLLGDRLQQVLLRAARDHTQVGILLVDLDH
FKRINDTLDHTVGDQLLREVGHRLQSCVRECDTISRQGGDEFAVVLPDLINNDEAPRIAE
RILGAMTEPYRFSDHDLHITCSIGISLYPRDGRSAEILLKNADNALYRAKDLGRNNYQFY
QSGATMVARERLTLENSLRYAVDRQQLELYYQPKWDFHANAITGAEALIRWNHPQLGLLP
PARFIPIAEDSGLVLALGEWVLRAAVQEIGQLHQNGASGLRVAVNVSARQFHQGNLTTLV
QGLLTESGFDPGSLELELTEGILMHHTEDNITALKSFKAMGVRLAIDDFGTGYSSLGYLQ
RFPVDVLKIDRSFVTELPSNESNVAIVDAIVTLAHGLGLLVVAEGVETVEHVEFLRAHGC
DEGQGYYFGRPVPLLEFQSLLMRDRARLAGEALSAVSP
>W6ME38|diguanylate cyclase|EC 2.7.7.65|Candidatus Competibacter denitrificans Run_A_D11|TrEMBL
MQKRCAADAALAPGRTWQVVLALGYGTAWLALWFASYQLNLVVGISAWFPAAGLTFAILL
ECGGWALALPVLVSLMANGSIWPLTAWPSYLAASVLPPLGYLGAALILRSYSGGHGPTRF
KDLHRVAAFLGASAGAAFFAALVSTYLFETAGLLPAQSSVWAVVLGWWIGEFVGVATIAP
LLLVYGVPWVQRLRQVSLPKRSSWRAIVRLCSGHLSFQLALSVGVVVLLFWLPSHFSQTQ
PQPFIALLWLPILVWIVVTHGVRGAVLAVLCFELTIIGVLLVFGPPALIWQYHLVMTAVA
ILGLITAAFFHEQAYNTVLFHDLAEISNDLLWEFDADGALRTLRGQLAATIRLHAGTASA
NWLRFIVEQEQDTDWVAVRQALSQRQPFRQQVLLMALPGRDQPIWTRNSGLPMFGVAGEF
LGYRGTTTDISDHKTTQTLQKKTEALLQDYNQTLEAKIEAKVEERTRALAEASLRNWRLA
NYDTLTGLANRNLLFEHLRKGLQQSRRQWRLLAVLLVDLDGFKQVNDMHGHDAGDELLRQ
VAVRLRNSIRASDTPARLGGDEFILLLPDLERPEMAVTVAEKIITCVAEPVSLGTTTVSV
SASIGIAIYRPESPATLEVAMNLLRQADSAMYAAKRGGKNGWRFAEQPGDS
>A0A330LAN0|diguanylate cyclase|EC 2.7.7.65|Nitrospira lenta|TrEMBL
MSPSIIKLLLVEDNDVDAHLTRDILAEWSIEQFDITHVTRLSEAFAHLARDRYDAILLDL
SLPDAYGLPTLKQVQATSPTIPIIVLSGVSDQALSLQAVQQGAQDYLVKGQGHPELLARS
IRYAIERKRAEERMTYLAQYDQLTGLVNRTLFRDRLVQAMARSKRLQRPLGLMLLDLDRF
KAVNDTMGHDVGDLLLKAVADRLKLCVREVDTVARMGGDEFTIILEGCAADQDITVVAQR
ITESLREPFELGSHRPAIGVSIGITVYPSDDHDIDDLLKHADAAMYRAKQKGGCTFQFHI
SDAKPQSPLVS
>A0A8G0W353|diguanylate cyclase|EC 2.7.7.65|Clostridium scindens (strain JCM 10418 / VPI 12708)|TrEMBL
MQKIFKKYTIIIISIAVLSILVINFFLSAKSLEKQQFNTFSVKIGQVIQTMERNQSELES
ITENLDEDYLTRAKAAAYVVEKNPSVLESVEEIQNLAELLNVDELHVSDSAGIIAYSSVP
RYIGLDFHGGKQMRGFLPILESDAEDEYVIQEAQPNTAEGKMMKYVGVSRKGIKGIVQVG
LEPVRQLEAQEKNTYDYIFSRFPTEQGEEFFAIDTKDGSVIGYTEGMEAADEAQTYSVSS
LKKYEDGGYWKDDNGEKRYIVTRMYDHVLIGASISEAVLYQPFWRNILLTFLYLALVEVI
AVILLNYLVKQKVVSGIHHILEDLSHITKGDLDTKVEVGGNPEFQDLSDGINTMVNSIVR
TTDRISKIIDIAEIPLAAFEYQEDMKDVFVTSRLNELLDLPKEEVERISRSPGQFLEMIR
TIMKSPIEGEPDVFCIHDKKYIRIHLSVDDGHYLGAVLDATKEVLDKRRMFYENNHDQLT
GLRRYAYFKYQASQWMEQMEKDEICAAVMMDLDEFKRINDTYGHDVGDKYLESFAALLKG
LPQEHCLVSRRSGDEFCIFICGFQDISEIQKILKELWRKLREEEAVITQDVIRKIRASGG
VAYARGQSRLLEDLLLEADQALYEVKRENKGLFKEYDADKCQEA
>A0A378TGV1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MNYVGQWWRQPDRYKWLSEYLATRRLLVAARTVMTVVSLILAVAVVLIPFSPAGQPGPAQ
AVVWVIGAGFAGMALLYARRWPTARQSTALSIAGSLGIAVTALTPVDPHTGLLTCWAFVG
LAAYVASFHTPKLLTFTVGVSLGTVAACALRTGLAGDAPLAVAVFLLSTGGLLTVAFGGQ
ILVRLVWNDAVSTDPLTGLSNRRGFRRSARTMIAEAARRGSSSFSVVMVDLDGFKSLNDT
LGHAVGDEVLVTVAATLREVCGPGVITARVGGEEFVVAQASPPGDMELLARRLCVAIAAN
RWGVTGSLGVAGITVRDLEADPGTVIERVVASADMAMYEAKRAGGNQIRQATAA
>A0A554XFK6|diguanylate cyclase|EC 2.7.7.65|Tepidimonas charontis|TrEMBL
MSASHRTDTTAPSSDRVGGLAHPALLGLVADWLWEMDASLRVVRVEPLAEAPKTPPLPRL
IGQRPWESPALVYAGQTLQRRWRPLWLRQPFRGLELQWRTRGDRPLWTSISGVPRFDAQG
QFTGYIGVAQDITTRKRLEQRLQRARAELHATLQALPDLLFEIDGDGVYRRVHAPRPELL
LVPPDQLLGRRLDELLPPEVLTIAQQAMEVARRQRQVHGLRYRLTIGGEERWFELSMARV
AAAGAPERFVAVVRDITELSMLAFFDALTGLPNRRLLLDRLQQALLRQQRRPTWAALLFI
DLDDFKRINDQHGHAAGDAVLVTLCRRMREQLRRTDTLARYGGDEFVAVLEGLGRSQGSA
RRNVERLVGQVRAALTQPIDGVVPGEALNVSASVGGVLFWGAVPVQALLQRADSGVYRAK
EGGKNRASIEMWVVAPSA
>A0A378T6Y1|diguanylate cyclase|EC 2.7.7.65|Mycolicibacterium tokaiense|TrEMBL
MKQWADPEPTVWRWHAVGLVALLLMLGLYAVAGYAAGGRGGLFAVLGTFAAVAVAAALLG
RACRWQESRRPMIAWPTIALLATLFAGWVDPAATRDLPGTITITFAFIGLACGRGRSILL
LPLGIAAFVIAADDPGLPTVVVTALMWVLVAEVPAWLIARLEEQSALLRRIAQTDALTQL
LDRSTLAARMSEHAADAAVLLIDLDGFKRYNDRCGHEEGDKLLVAFADALRQSIRGEDLA
FRLGGDEFLVLLPRADQTAAEGVLVGLRQRWSEAGTPVSFSVGIAAAEPDLVRVADERMY
RDKRSRGLPAD
>A0A8E1RU37|diguanylate cyclase|EC 2.7.7.65|Enterobacter sp. 50588862|TrEMBL
MQRDTFVVRRSFLQWLHKRSNPGLIVNLCFITVLVFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQYSVDKMLLFRQSMRDALQTPLAFNVLHDAVSHFNALRMRPTWQLLVDR
NRTLPINGVSDAFVEKTSILNRDAERISNEISAALEVGYLLRLATSSRHSESRVIYVSRA
GFYLSTDTLTEASDIIPRYYHLVTQSWFTQQSERNNRSRAVRWFISTPSSWTGDERTITA
SVPIYFNHYWYGVVAMDFSLNTMQRLLAEATDDRTEGEYQLYDSRLNMIASSEKTDKQVN
HFDERELAQIAQAIEHDTGGGIRLGSRFISWQRLDHFDGLVLRVHTLQEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLKWQAWHDPLTRLNNRGALFERAKLLA
KKCHQQSLPFSVIQLDLDHFKSVNDRFGHQAGDKVLSHSAGLISSALRKNDVAGRVGGEE
FCIVLPGLGLEEARGVAERIRCRINSKEILVKKSTTLRISASLGVSSARENGNYDFEQLQ
SVADARLYKAKQDGRNRVVWHDHDKK
>A0A6V8LQP1|diguanylate cyclase|EC 2.7.7.65|Desulfovibrio sp. FSS-1|TrEMBL
MLHLDAKTVAVIGIILHVALALVLMQTYLTRKTYPGFLPWIVSQAMWVVGSAAVFLRGAI
GEVASVIVGNAAYLAVMVLLSLGHTLFYGYDRRGVRLKVHLALSAVILGVAMWFLFANNS
LQARIVNLSLGLALLLLDTAAAPLLHPVGRRYSIQASMSACYFLVVLCLLGRAVATAGAP
GISDMLSQDAWLTLVLSVGLVSMVFSVYGFVTLTQSRVEEELLEAQASLRRQAETDPLTG
LNNRRAFDDIARHDERLTRRYGQRLSLVLFDLDDFKAVNDTHGHQAGDAVLAAVARICRE
SVRDVDTLCRWGGEEFALLMPQTGLAEAREAACRLQQALGELRLPELPGLRVTASFGVAE
LDGEPFAGLLARADRALYTAKGQGKNRVDACDPQEA
>A0A8B3UGA2|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASSADTLERQAVEQRQKFDQLTEDIETDIWAQS
DLARLYVIKKDPQVLKEYNQAENSLKSIELRLEKLQDNGASDEELALLHEGIKIVDELQD
EQQTALTSATQGEDAQAVALLYGAPYEQELERAQSQLDHFRQILDKRVIASVQDATKKSK
ALRTASELMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAIRIFRENGLARQRLERERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYVLDREPWQMRCVAQWLSPVGEETSFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPAPQADSSLCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQTAQALRTGEPLSCMMIDIDHFKSINDRFGHEA
GDQVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLPGADEPEAHACAQKIYTGVHELSIRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A7Z2FRM1|diguanylate cyclase|EC 2.7.7.65|Enterobacter asburiae|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFLVVLVFSTLLTWREVVVLEEAYISSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDALQNAVSRFNTVRTLPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDAERLSHEISAALEVGYLLRLASSRAQTEARVIYVSRA
GFFVSTDTPDQAGDITSRYYHLVTQSWFTQQSERNNRARAVRWFISTPSSWTNDERTITA
SVPIYFDHYWYGVVAMDFTLSTMQRLLADATEDRTEGEYQLYDTRLNMIATSAHAENAVN
HFDERETAQIAQAIEHATGGGIRLGSRFVSWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKLLA
ETCRQQSLPFSVIQIDLDHFKNINDRFGHQAGDKVLSHTAGLIASALRKNDVAGRVGGEE
FCVVLPGIGLEEARGVAERIRCRIDSKEILVKKSTTLRISASLGVSSADEAGNYEFEQLQ
SVADARLYQAKQCGRNRVVWRD
>A0A0T9UGZ6|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MLTAHLDALNILSTPIWVVTPKNQELLFANKEARKIAGDCQLPLMRNGRFSAHAQQQLDA
YLPALVGDDQIVEIWTIECEGNAFPLSCRLSLAQLEPYGDVIVFEGLYISEKVLTQPGVG
QLCSTSYRRDEMGFYEQFFNTNTAPMLLIDPSKEGQIVDANQAAIRFYGYSRDEMCMKHT
WEINTMGRDVLPVMNEVAKLPGGHKPLNFIHKLADGNIRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEQAHAQSQRYGHHFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIIRESDSVFRWGGEEFAILLPLTNLEGALQVAESIR
ETIQMICQPNLPQLTVSLGVAQHQIGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A653IMZ8|diguanylate cyclase|EC 2.7.7.65|Novosphingobium sp. 9U|TrEMBL
MQGQNSFTADLRVTSTRRVAIMGIQALSCVSIAVAVFGPSQLVRPAASLALVVMVIVFLT
GLFFARGAVSQAIRQRTLFREAEETKQQVEELFAMTDMLQAAEDHEDAGSVLLATARRLL
PEFGGALYVFNNSRDRLDLAKSWNVTESFHPSDTLLPSNCWALKRGKQHINDISRETLCC
MHTIGTAPNIEVPMMARGQVHGLLVLSIDGEEAFDRLEQVGRVARALADSMSLALSNIAL
REKLRTQSLRDPLTGLYNRRYMEDALERYISLAERTGSATSVLMIDLDNFKRLNDEHGHA
KGDAVLRDVAAQLVTALRPSDVVARYGGEELIVILPNCGIDDAAIKAEMLRMRIEGLSDA
HGVAVSASFGVASVPQTSTNAADVVPMADAALYAAKKAGKNCVVCTDKRAGRDDKGTPRL
AVTG
>A0A380PTB2|diguanylate cyclase|EC 2.7.7.65|Yersinia frederiksenii|TrEMBL
MLIAYLDALNILSTPVWVVLPKNQEILFANKEAQKTAGDCSLSLMRNGRFSAHAQQQLSA
YLPALADGDQIVEIWTIQSEKNAFPLSCQLSLTQLEHYGDVIVFEGLYISDTLLTQPNVG
QLCSTPYFRDEQGFYEQFFSTNTAPMLLIDPSREGQIVDANQAATRFYGYSRDEMCMKHT
WEINTMGKDVLPVMNEVAKLPGGHKPLNFIHKLSDGNMRHVQTYAGPVELDGIRLMLCII
HDITEQKRLEQALEHAALRDPLTDLGNRRQFFPLVEQAHAQSQRYGQNFSLILLDVDHFK
SINDQLGHHKGDEVLILLARTLESIIRECDIVFRWGGEEFVILLPLTDLNGALQVAESIR
ETIQMICQPNLPQLTVSLGVAQHQVGEDTDSLFKRMDEALYRAKASGRNRVLAA
>A0A4V6HRG8|diguanylate cyclase|EC 2.7.7.65|Robinsoniella peoriensis|TrEMBL
MDIGNQGVGFVEKFLYYYYKEWNPEKITDMMDCEILWFETGIDTFYSGQDAVLKLAEEKR
TANFHSYEITEPLYKTKRLGRDYCLVLLKARLKEKSADKLCKSHEILITAICRLTDTEEK
LCYFHVSAPAADIEARNLELLMLTNNVPGAIFCCKYDERLTLTQMSESFLEMFGYTQKEI
EEKFANSFWEMIDARDREATLEDVKKQLALSDTKEIEYRIRKKDGSVAWILDKGRLITAS
DGSGIFYCVLVDITKGRLAQEELAMSLERHQIIMDQTNDIVFEWDIERDSLSFSANWEKK
FHYEPVKERFFASLSYNSHVFREDLPAFRNAFDQIRRGKGYMEIEARVKKTKEEYIWCRF
RLTSQLNKDGIPIKAVGVIIDIDNEKKNSQQLLEKAERDPLTKLYNKGTAHALIDNYLQS
SNMGKQSALMIIDIDDFKMVNDTLGHLFGDAFLVEITSDVRKLFRESDIVGRIGGDEFIA
FIKDIPGNALVFEKARQVVEAFRNLPMQESWDKSISCSIGISVFPNDGQHFQELYKKADY
ALYQAKKQGKNQYVHYDDSIGDGFPGIPVSMPTAVNEKIDSNEGMGNTLNSKLVEYIFKI
LYKSIDVEAAVSAILEIVGHQFNVSRAYIFENTEDDRYCSNTFEWCNTGVKEEIDNLKHV
SYDFDLGGNYVANFNEDGIFYCRDIMELPRKQKAILEPQGIKSMLQCAITDNGEFKGYVG
FDECRMNRFWTQEQITTLIFTSEILSTFLLKKRAQDSVVQTLEGMQNILDNQNSWIYVIG
AESYEMYYINQKTKSLVPDVREGMCCYRKFFDREEPCENCPVKDLDDTVKNCTKEFYNPI
LNVWSSADASRIRWKGKDAVLLCCHDITKYKIN
>A0A1U9Z2C0|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MLENLEIIIAMLEKVGMAALIVLAYRLIRYARFSIVRSSLAIGLLFGFGAVVTMVDPLEV
LPGIIVDIRAVMVALAALFGGPLAALIASAVTIAMRIYIGGAGALAGCVSIALAAVIGLV
YARLSGGRRDPVGLAILGLLLSLTLVAGVFAPVPIVSSTTPALIIRNLLGTMILGYLLAV
EERREAEYRAYKREAERDPLTGLKNRRALEAFDRQVTTEAERRPFAVLMIDIDGFKSLND
LHGHAFGDMVLRRLAEVVRGRMRGFDLVVRYGGEEFCVVVKEATLHNARRIAEDIRLQIM
EERFQAATEEIGVTVSVGVAEANASTLSVFHVIEHADKALYDAKNDGRNRVCIYSLETDR
RQKLHQA
>A0A1U9Z7A1|diguanylate cyclase|EC 2.7.7.65|Martelella mediterranea DSM 17316|TrEMBL
MDKSGDPGLFGRWFRGLSLRAWLIVGFMMALLPVALLSAFWYLDYRDQLREPFRQVLHTQ
HKVSLALERIQGNLWDIATDVNDFAQTGDESYRDRFETAERDIAANLCDLEMITETYPSF
DPVLEGVRQQWTLLLEAASNVSPLPGGADQPLMRFESVIGETGKRVESIAESMRLLNEES
HRQALETMERLDRFAAIAGVLALVFSGIGIFIIDQALIRSTDKLVEGAMLVAGGTRNREI
EVQVPPELASVAQAFNTMLKQINQQEDALSAAARADGLTGLYNRREFDRALDEAIAVSKE
SGEPFSLLMIDVDHFKQFNDTHGHLAGDDALRQVADTIELSARENDRAYRYGGEEFAMIL
PGLRTYEATAIAERLCNTIAAQTLILPDGQKQTLTVSIGISVFSPRVSPPNIIELADRAL
YAAKMEGRNQVKVTG
>E1VC98|diguanylate cyclase|EC 2.7.7.65|Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)|TrEMBL
MVDEKDESTQGGAEVVHHPTVRWPMLAASGTAAGIVLLDERYRILWANERFGVLSGWPLD
DVVGYAGKELVYRQALKPSWFTTELRAGAWQHVQLGDGEAESVRGVLMAETHLASRRDEA
AILWTFVDLRDEAPHRFHASLDGMVSIWVFEDRLQHGLARAARRDRQVGLLLFRLDDREA
LGERFAGTCLEGLQQQVGRRLVQTLDVEDSLTRLGQDHWGVLIEQPVSPEDLQMVALSCQ
EAMEAPFRTASTAPLLTLSVGIAVYPQDGDTSELLIKSAETALSRAPPASHAFFDPSLEA
ILAQRLALREFVQGALLQPALHFRIVYQPRLDIHDSRCRDVEAQLRLRHPEWGELLPSDF
LPVVAEMGQAAWLDQWAIERVAAQRAAWQDMGGELATLGVSLDVDATTLDQAVAGRRPLD
VMLRRLSMDLSWLCLELEERAFIAQAAEHTHLFRRLTALGVRLAVSHAGQEPVDIMRLAG
LPASRVTFGSRVAAAIHRDDTSAARGLEALARCLETLQLEGVVTGVTSEVQWQVAGCLAA
GLAQGDGLCEPLEAEALAAWLAARA
>A0A822X7X8|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MISVIITMTLIWLLLCFASVVTLKQYAQKNLELTGATMSHSLEASLVFNDSLAANETLAA
LGKQGQFAVAEVINGHKKRFAYWSWNPKDNNDTLGALVSRWLFPVPVAQPILHNGAKIGE
IRLTARDSLISHFIWMSFAVLTGCILFATVVALTITQSLHRGMVTALQNITDVVHDVRTN
RNFSRRVKDGRIEEFHQFGEDFNSLLDEMEEWQLKLQAKNAQLLRTAMHDPLTGLANRAA
FRNSIAALMNDPSAKTNSALLFLDGDNFKFINDTWGHAAGDCVLIEVASRMVEFGDKRHQ
SYRLGGDEFAMVLYGVHSEPEVQHICAALAQQFIRPFDLHNGQKASMSLSIGFALAWENA
SVEALLEKADRNMYQVKNQRTKTIS
>A0A509DTH1|diguanylate cyclase|EC 2.7.7.65|Thalassocella blandensis|TrEMBL
MPKSQYHDIQKRIDMDLLSRSTFALFVYCAIFPVILYPFGLFESHPAMSWGISIASVCVS
LIRFTHLKLADRFYERSPVLWMAIFKACSMSHAMILSTLFVLVTYHPDFTPAYAATLLTA
AGISSGGISSLSPNLFMAIVFPVILLLPTIAVNFYLDGTRALGWLMALYLGYLCALARRT
NIEYMRTFAIEEQLERQKKELETLSRTDALTGIYNRGYFNSLYDMIWDSSVRNNIGITLM
MMDVDHFKHVNDTYGHVSGDECLKMVADSLKECLKRKTDISCRFGGEEFAVLISGTPIHE
AEKLAENIRKCIASRRVENGEHRFKVTISIGLANILPKLGDKPIRLVEQADQALYRAKKS
GRNCVRTFHMN
>A0A1M4NDH2|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. N3C|TrEMBL
MSQNDYKNIITVPEKNETRAYCIAILNNDKILLSIINKAISSIDEEYMNTLILNAATEIE
REITMSMILEFYGIHIFVAVCFIMIILLISIFHNIRTKNEIKLQYEGYQRLSKTSNEYLY
EYNVKTKGLELSKSCIDLFGDINNLSKLKACINKAVMNKGNTIFIIELPIANGEKRFFKS
VNSFLYNDKGTIYSMIGKLVDINEEEVEKKELIKRSERDGLTGIYNAITTRDLITERIKS
TDLNEKDALIIIDCDYFKDINDTYGHLQGDKVLINISKALTQTFRKTDIIGRMGGDEFCV
YMSNIPSSDFVVSKCQQFKGLIKELMIGSNVTVSVGISLLVNGDSYEDLFQKADKALYDA
KKKGRNQIQFFK
>A0A822X2A9|diguanylate cyclase|EC 2.7.7.65|Enterobacter bugandensis|TrEMBL
MMNDDIYYYKKRIREEWSLTLSQDDPHRTGIQFARRARLARVVGLAAMFFPVAEILVSHF
LPGGWWLLLVGWAFIWPHFAWQLSCRAASPHQQEIFNLKMDAVIAGVWIGVMGMYVLPTA
ALVMMVGMNMMGSGGCRLFIAGIVLTLLTALLTLPLAGRALPFNPGALEWGLTLPVLMLY
PMLFAWLSHRTAVRLAEHKRRLEMMSTRDGMTGVFNRRHWEMLLRNEFEHCRRSHCTATI
LLIDIDHFKNINDTWGHDAGDKAIVAITRQLQMSVRSGDAIGRFGGDEFAVIMSQTAAES
AIAVMSRVHARLETLSLPCAPKEPLRISVGVAPWGPQFVHYREWLKAADVALYKAKNAGR
GRTEVAA
>A0A381DJT8|diguanylate cyclase|EC 2.7.7.65|Campylobacter sputorum biovar sputorum|TrEMBL
MKTGESKISLYWSKGFHINNSYQKGLIGEIMDVTREKQVEIELIQTIKKLEIANKTIEEN
SKLDALTGLYNRSILIDRMQLFANLFEEQNIEFCVLMADLDFFKKVNDTYGHKVGDEILI
KFAKILNDSCRKNDICIRYGGEEFLIIFPKITLEKAQKVADRILKNTEKQLLLPDNKPIT
TSIGLTSYRKNDNIDQCLIRVDELLYEAKNKGRNRIISR
>A0A3V2XSY6|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MFPKIMNDENFYRKAVEQTVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVSGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKADAILSGMWIALTGVNMM
PAAALFMMMCMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEITLSLPVI
VLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKRINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1C5X3F4|diguanylate cyclase|EC 2.7.7.65|uncultured Coprococcus sp|TrEMBL
MNNDTINVDISKKWQLLLWKVFLSVAIMFMVVEVIICLVKKDLGMARGAYMGLYVAIPLV
IYAGVLSGTLYVLKKNKLTENGADWLVSMMMFVIFIVPAFEHYDAIVLALLPMVSIVITA
VFANQNITLVMTLLTFCSLIINDIRLYSLFEWKEISFWAYVTASFGLVLVLSVVTFLLNM
HTKELMESIGNFTVRQMNLMTELRKDPLTGLYNRRSFEESLEKEIRRTEENGEKAYIAIF
DIDHFKNVNDTYGHSNGDVVIKALCKMLKEKSKDYGLAFRYGGEEFVILFNNIELPKVIN
VVEDVRTEFRCYYFQFMNNSGITCSCGVAEYSKGESAKAWFNRADNSLYQAKEAGRNRTV
VSE
>A0A3U3RHI4|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKTQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A1C6YY07|diguanylate cyclase|EC 2.7.7.65|Hafnia alvei|TrEMBL
MSSNNLFFRLLSQRQDVITVILFVISAACFTLFYYKTETTVKQMEFLLKLSSARSDFLSL
SASTFYNIDNQKTNKQLKDSQLQALQLSYSNYINLLHTFSIPGRLKEREETASNELFNRV
INARHGDSGIMVLPQNTQNFRAIIEESLEEIKYTFHWQLILLILIPFFIAVIRTLHGLYY
IDIFDKMNKDYYMDFLTKAYNRRYIPKIKKRADLDYILAIDIDHFKQINDSYGHDIGDEA
LYKCTKIMQGNIKASDIVVRMGGDEFVVFLFNASLKDAKHVTEQILHDINDEKLYISESV
TAKMTVSIGVAKFDDDISTTMKLADVNLYESKSRGKKQFTF
>A0A3U2S0J0|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica I|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARSSAMLALETMYVSRSGFY
LSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTASLP
LDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTANTLN
DRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISIALT
LLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLAKRY
REARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEEFCI
VLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQSLA
DKRLYYAKQSGRNRICASDATQEREKK
>A0A7T9PEC7|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKQYQRVLVTTPHPLLRLVCLGLVTFIFTLFSLELTRFGTLLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSFGNIFASWMLFSWASINITYTAINIIEATVGALLLRKLLPWYNPLQN
LNDWVRLALGSALVPPLVGGVLVHFLVPSAEPLRNFLVWVLSEAIGALALVPLGLLFKPH
YLLRHRNPKLLLETLVTLVVTLVLSWTAITWLPWPFTCIIVLLMWSAVRLPRMEAFLIFL
FTIMMVSLMMARNPLSMTPSSMIVTFNAPWLPFLMMLLPANIMTMVMYAFRAERKHITES
EERFRNAMEYSAIGMALVGIEGQWLQANKALCNFLGYSQSELQSLTFQQLTWPEDLNTDL
EQLQQLIHGEINTYTLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQT
EWVNKRLMERITLANEAGGIGIWEWDLEPDVISWDKRMFELYEIPSHIKPTWQLWHAAMV
PEDRTHAEQVLRESLQARVPFKLEFRIRVKDGIRHIRSLANRVLNKQGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPI
LKVLHITFGENGPLMENIHSGDMSRTDIEQDVVLNCRNGGSFDIHYSITPLSTLEGHTIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFID
LDRFKAVNDTAGHAAGDALLRELSSLMLTMLRSSDVLARLGGDEFGLLLPDCNVESARYI
AGRLIDAINNYHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVV
TVYEPQQERIHSTRSMMSLDEQWHMIKDNHLLMIARSVASPRIPESSSFWLISLRLWTSQ
GEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAKGMGVALPLSEAGLASVTLV
DELLDLITKGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFS
QLSANTADYLLLDADVVTNVHGNLMDEMMVTIIQGHAQRLGIKTIAGPCHQSIMMDTLSG
IGVDFIYGDTIGEAQPLDLLLNTSYFAIN
>A7MJL3|diguanylate cyclase|EC 2.7.7.65|Cronobacter sakazakii (strain ATCC BAA-894)|TrEMBL
MPDKLLISRWRTKNPIRVVNFCFCAVFIFSTLLTWREGVILQDAFISSQRNQLDSIATAM
DRNLQYSVDKLLFYRAGMRYAMHNLLEGPQTDALIAGFKAERDKPEWTLPTGRDLAPEIQ
GVSDTFIGQSTLLERDDALLYSELNATLALGHMLSIADARAERPEVRTFYVSRAGFYLTN
LPFYGHGSIPELYYQQVSSRWFLDQSRRRNPGRGVRWLHGRDLSMPTGQRVTASIPLDDK
GRWFGVLAMDFPIGAMRDFLKNALNADDSGGEILLFDSQLSPIATTASGSDTALHFTAQD
KAMLARQMELGNEGDARMDTRFITWAKLDYFDGVLVKVTTVSQSAEGKFGKVAMVLGLLW
LLFTAMLFLSWRVIVGMVRNMLTMQRSLKWRAWYDTLTRLYNRGAFFERARMAAKTCFAQ
SEPFSVIQLDLDHFKSINDRYGHQAGDKVLTWAAGMLSRSLRAQDVAGRVGGEEFCVILP
GTTADGARQVAERIRQRINSQEILVRPDTTIRISVSVGVSEARRDGDYDFEHLQSIADHR
LYLAKQRGRNQVCDEG
>A0A8I0UQ49|diguanylate cyclase|EC 2.7.7.65|Enterobacter hormaechei|TrEMBL
MNKEVAPTPRPTFKRTLRRISMISVIITMTFIWLLLCFASVVTLKQYAQKNLELTGATMS
HSLEASLVFNDAVAANETLATLGKQGQFAVAEVLNAHHKRFAWWSWNPADNTDTLGALVN
RWLFPLPVAQPIIHNGNVIGEIRLTARDSLISHFIWLSFAVLTGCILFASAVALTITRSL
HHGMVAELQNITDVVHDVRTNRNFSRRVTEGRIEEFHQFGEDFNSLLDEMEEWQLKLQAK
NAQLLRTAMHDPLTGLANRAAFRNNIAALMNDASAKTNSALLFLDGDNFKFINDTWGHAA
GDCVLIEAAKRMVEFGEKRHQSYRLGGDEFAMILYGVHTAHEVEYICAALSQQFIRPFDL
HNGHTASMSLSIGFALAWENASVEALLEQADRNMYLVKNQRSKTIS
>A0A731XUW9|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. VII serovar 40:z4,z24:[z39]|TrEMBL
MFPKIMNDENFYRKVVAPPDPPDDHQRSGLRFARRIRLPRAVGLGGIFLPVAAVLVSQPV
FGGWWLLLVGWSFVWPHLAWQWATKSLDPLRQEIYNLKVDAILSGMWIALTGVNMMPAAA
LFMMICMNLMGAGGLRLFIAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVIVLYP
LLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHREATLL
IIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTPADSA
ITAMSRVHERLHTLRLPRAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKNAGRN
RTEVAA
>A0A366G886|diguanylate cyclase|EC 2.7.7.65|Achromobacter marplatensis|TrEMBL
MSSSNSAVPAWTGGAGQACYLSASNAQAWEAVYQSVDAYTRGQVAAVVGDSAKELVDAFY
STLLADAEAGPRLSHEIVATRLHSGMKLWLKGLLCVRDQGDIVALMATQKKVGEVHARVH
IPIHLVMAGARILKNEIAERLRASDLDGTAASIATQYVCNLFDLAIEQMSRAFMRDINRG
ARNDEAYRLFALGQNISTERERQRAALLEWSQAVLIGLHYRAPEQALPRLAASEFGLWLQ
HKGGVLFESAPALRQITEAVTRLDDVVLPRLMLADAQQQVSMPDQVRELQELVARIKHLL
NGLFDMVAEIESGSDPLTNVLNRRFLPSVVGREIAISTRQGSRFSVLLLDIDHFKAINDA
HGHSGGDHVLRQFAEVVHQACRSSDFVFRYGGEEFLVVLVDTGQEAALAAAEKLGAEIRR
HKFAIPEAGALGITASIGVATFDGHPDYAYLIDRADKALYRAKQEGRDRSVAA
>A0A2S3U855|diguanylate cyclase|EC 2.7.7.65|Lactiplantibacillus plantarum subsp. plantarum|TrEMBL
MQEVAATVTTVLAANDEKVKLYRTGGEEFNVLFPGYDLASTKVIVRQVFEAVNHLVVKYE
DEEINVSISVGVSTLHQADGSPIDLYNRVDQNLYFSKRHGRMRVTVE
>A0A0U5IKQ7|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MDASSAEMRPSVDLSLRWKALIAMTLALVLVNASLALIANFQLASQFELQQSAVRDQQAR
QLRALVEEGTQEMSKLASLVPLLGGNASDMASPDDQIRQALLTNGAMLDLEWDIRSVHWI
RPDGTTAILWPDGAEDIPNALRAELLQTPERAIAALLCSPECRQYKATPLLWEGSFAGNL
VLGRSLADALLAFNALTGAKVAVSWSDSTRSADVLNPGSSNYLRFPAVTYPDDTLPVLRS
ATPALRGGDVSDEPLLIPHGNGWFEIFRIPSLAAGIDALVINDVTAQREAIHTATIGSVL
LGILGLILSGSSLLLIIRGPLYRLRDLATVIPLLAENRYSDLRRQLPRRSNSLMLRDEID
LMTDTVGSLTDRMELLQYDREQAEARLVWLADHDPLTQLFNRRRFNDDFERILDQTIRFG
HQGALLFLDLDQFKDVNDLSGHRVGDTLLQRVSEQLRQVTQTSDLLARLGGDEFALVLPE
ATEDDALASAESVQEAVCSISLQEHGRRHRVTASIGIVMFPSQGNDIGQLMANADLAMYQ
AKEKGRGRWYLFSEEDQGKEQLDARVLWREQINQALSQNRFELHVQPIIEIATGRLRHME
VLLRMRDARDAMVYPDRFIPVAERTGQIQAIDRWVIDNALAAMESRTDLRLSINLSASAM
DDPLLLTDLRHLLERHRIAPERISFEVTETAAINSLLNATRLMRGMQELGCRFALDDFGS
GYASYAYLRKLPVDEVKIDGAFVRDIVKNPEDRIFVKAITDMAHGMGKRVIAEFVENAEI
LAILKSLGVDDAQGYHFSKPVKLEQPGTPIMFDGVL
>A0A0U5IEE4|diguanylate cyclase|EC 2.7.7.65|Thiocapsa sp. KS1|TrEMBL
MTMHKIDTAEMTDLRERARRILRDHTFDETIAAFDQGELDLERLLEELHIYHAELYIQQQ
ALCDSQQFTERALARFTRLYRELPFPVVLISGQGRIKEGNAAAHRLLPLDCRLFSHLAIE
GQTRLLENALLDARNNGRGDCREIRLRGQAGGTLIADLRLIRLPEMDGDASEILCNLVDQ
TEQVAQREDLIAANRRLRIQEERYHVVADFAPDWAYWMGEDGRYRYVSPACARISGYPAA
AFLKDPELLMRIIHPDDRAGYLAHLHGEHADNRFKPLRFRIHTRTGELRWIEHLCTPVTG
DGGRPLGHRGSNLDVTDRVALEAAVDRASEVIDASSTIAFHWAPEPGWPVLYASANVRRW
GYGVERLISRELTYLDLVHPHDRGRLVDTFEAFSESQRDTFRQTYRVLWADGSEHWVDEE
THNVFGPDGRLAYFHGVVTDVTERERAQQDLKNQLDLQVLVAQVSSRLIDATGDTLEQAI
GWSLERIGCTLGADRSYLLRLANDRESLDMTHEWCAAGIPSFIVECQDLSLLRYRWWGER
LAGRDPVLIPEVSALPAEAAAERAELERQGVRSIATVPMTRHGRIWGALGLDAVTRVRTW
SIDAIRMLQVIGEAITGALLRTESEVRLAASENRYRRVTAMMSDVAYSCLGHPGEGFRID
WMTESVAALTGYSLDKVREMGCWGRLVIAEDAGVFADKVSGLSPGTRADCELRLRRKDGA
IRWLRATTECLAEEADRGALRLYGGLVDITEHKLREAEIERLALVVEQSPSIALLTDTSG
AIQYVNARFCSTTGYRPQDVLGQSIDILRSASRTLDEDSEVWSTLGRGEAWIGELENRKK
SGESYWEHAKITPLRDRQGLITHYVKLAEDITDRKALSEKVSYLVQFDPLTGLPNRTLMR
ERVEQALIAARHSGRGLALLSIDLDDLRAVNDSLGHPAGDQLLRAVAQRWQPLLRDEDTL
ARFSGDNFIALATGLRRVEDASLLADRIRDALAQPIVLGEQAIVVSCSIGIALYPDDAET
AEELISHADTALHGAKIEGRGLHRFFTSALNADFQEQFRLEQALRRGIDRGELLLHYQPR
VDIVSGRIQGLEALVRWDHPDLGLIAPGRFIPIAESSGLILLVGPVVVRLACEQIAAWRA
AGVPPVPVALNLSAAELYQEGFSRRISELAMEIGVDPGLLELEVTESTAMRSIDQAVAVL
SELRDLGFALAIDDFGTGYASLSYLNRLPVQTLKIDRSFLAEIGSGQDGKSQAETIVKAI
IGLGANLGLRVIAEGVETEAQRMFLVDHGCREAQGFLFCRPEPAEQIEALLRSQLIVPRD
DRID
>A0A377D0N5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQL
LRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHATGDRV
LIEVAKRLAEFGGLQHKAYRIGGDEFAMVLFGVQSDPKYSGFAQH
>A0A377EDJ0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRWHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A5F1QGR6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGGLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQVDIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSAPRW
>A0A6N8QHD4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIALAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETL
>A0A6D0INP7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
ITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLRE
ANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGH
NSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYH
LGDVDLYYPG
>A0A827RLX6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
LQLFAGLIAQYIQKEALVEQLREANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHL
NHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNTLQQNGEVIGRLGGDEFLVVSL
NNENTDISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAMY
QEKKHKQKTPFVAHPALHS
>A0A8H0LIS2|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
EIVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRDAVTEFEQHRDEHAWKIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A8H1MKU7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAMLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEACNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIANAQLLDLLVNRSYFAIN
>A0A376J7K1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKDYLRISSTVLVSLLFGLALVLVNSWFNQPGVEEVVPRSTYLMVMIALFFIDTVAFIF
MQLYFIYDRRQFSNCILSLAFLSCLIYFVKTVIIIQQIIEGRLTSSVVQNDIAIYYLFRQ
MSLCILIFLALVNKVSENTKQRNLFSKKMTLCISLFFVVGGPIVAHILSSHYESYNLHIA
ELTNENDQVVWKTSYVTIMIFMWLTLLSVNLYFNGLRCDIWNGVTVIAFCAVLYNVSLLF
MSRYSVSIWYISRTIEVVSKLTVMVIFMCHIFSALRVTKDIAHRDSLTNIFNRNYFFNEL
TVQSASAKKTPYCVMIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGG
EEFGVLLTDIDTERAKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQENALNPE
>A0A1V5QVX1|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MDKAAPLEVLIVEDASGIAGLIQLFLQRSGLISGKNAGVRVAGSLAQALEYAGSNPPDVV
LLDVTLPDAEGLQAVSALRAVVQAAPILVLSDRDDADFATEVIQAGAQDYLVKGALDKKS
LERAVRYAIERERIEARLKLLDSALEAASNSVVITDIGGRIEWVNPAFTVQTGYSKSEAL
GRNPRQLVYSGRNSKALYAQLWQTILAGKTWHGELINRRKDGSDYDEEMSITPVMDRQGR
IRHFVAIKQDISERKRAQDALLESERRLELALAGADLGLWDWDIAAGTLSCNARWAQMLG
FGIGELEPLLANWEKRVHPDDLPSVQQARQAHLRGETERYESEYRMLHKEEYWVWILDRG
KVVARNAKGKPLRALGTHLDISPRKRSEEALREREAKLTILLASMPDLVLMVDTSGNLTQ
CDLPAGDWFFTVPPPFEGRSYSQVAPPPVVQALDEALAGIIGDGQPRVCELSAPAGGEER
RFQMTVNQLADSSRFPSGFLVVVRDVTEQRRTEQKIRELSYHDVLTGLPSRRLLMDRLQL
ALAAAQRSRGFGALLFIDIDRFREVNDRCGYAQGDRLMVGVSERLRDCLRAGDTAARLGS
DEFAVMLAELGGDPGEAKQRASAVCDKILAALAQPFPLAEEVWAGSASIGVRLFQAGSQG
PEDILRRADRAMYEAKAAGRATWRFAEEEGDR
>A0A8G2H3K7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFIAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A6D0IFN4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
LTARDSSISHFIWFSLAVLTGCILLASGIAITLTRHLHNGLVEALKNITDVVHDVRSNRN
FSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQAKNAQLLRTALHDPLTGLANRAAFR
SGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHATGDRVLIEIAKRLAEFGGLRHKAY
RLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFDLHNGHQTTMTLSIGYAMTIEHASA
EKLQEIADHNMYQAKHQRAEKLVR
>A0A484WRZ4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIMDIDHFKKVNDTWGHPVGDQVIKTVVSIIGKSIRPDDLFARVGGEEFGVLLTDIDTER
AKALAERIRENVERLTGDNPEYAIPQKVTISIGAVVTQKNELNPKEIYQLADNALYEAKE
TGRNKVVVKEAEILINRKDDE
>A0A8H8ZT47|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLASLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQAAAHSERAAISLDEQWRMIKENQLMMIAHGIASPRLPEACNLWLISLKLWSCE
SEIIDEQTFRRSFSDPALSHALDQRVCHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELLEQLENSPLPARLLHLIIPAEAIFDHAESVQKLRLAGCRIVFSQVGRDLQ
>A0A1V5QW21|diguanylate cyclase|EC 2.7.7.65|Betaproteobacteria bacterium ADurb.Bin341|TrEMBL
MSIKTRILILGFLATFFLSCAVGFVLWSEYRDKANKQALLSGMEKVERLSALINELQRER
GVSAGYLSAATDFARTRLQSQQADTQQALRRLRAGDSENIEALRELASTQEKVAERQMSL
TDSFAWYSLAIVEILDQIEGLEKNANLPALKRDLHAHLHLLNAKEHLGQIRASLTEFLAR
KDQAPTHGLARQVGLHRYHARSFQQDASPALQESYRATSESPAMKSAFAVVDAVLRCEPV
DRAADQWFSTATSAIDDLGQIENQSLTDLRQRVAEEIRLSEARLWWVSLTAVFVSLICLS
FVATSVHRLVFAFGRLVASIRQTISTSDFAHRITPAGDDEVSDIARNFNELLEIAEGLIE
EKDRLASTDALTGALNRRKFPELFSHELRNQSEYAGTTTCLSMIMFDIDHFKQINDGLGH
AAGDAVLKEVAGLVKSLIRKTDVLARWGGEEFMILVPNVGLETASQLAEKLRLAIEKHAF
AESIKVTVSFGVSEYHAEDTLETICQRADEALYAAKSQGRNRVCLERIDPLK
>A0A8F9DS06|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPRPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLAFGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADLSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQTNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQAAAHSERAAMSLDEQWRMIKENQLMMLAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVASKGISIALPLSVAGLSSATLV
NDLLEQLENSPLPPRLLHLIIPAEAILDHAESVQKLRLAGCRIVLSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGEVIADAQPLDLLVNSSYFAIN
>A0A827LVD0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGLIWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNDVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTHNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHAEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRV
TVYEPQQATAHSERAVIPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLQLQNDE
GNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTVKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSASVQGNLMDEMLISIIQGHAQRLGVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIANIQPLDLLVDSRYFAIN
>A0A831FAK3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASILLFSTSSLNMTWTTINIVEAVVGAVLLRKLLPWYNPLQN
LADWLRLALGSAIVPPLLGGVLVVLLTPGDDPLRAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFESLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMMAADPSLLATPRTYLMSHMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQSNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDL
QQVEKLISGEINTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRT
EQVNQQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVL
PEDRQHAEKVIRDSLQSRSPFKLEFRIAVKDGIRHIRALANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPL
LTVLHITFGDNGPLMENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFID
LDRFKAVNDSAGHAAGDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFI
ATRIISAVNDYHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRV
TIYEPQQATAHSERAAMSLDEQWRMIKENQLMMIAHGVASPRIPEARNLWLISLKLWSCE
GEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVASKGLSIALPLSVAGLSSATLV
NELIEQLENSPLPPRLLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKA
NMADYLLLDGELCANVQGNLMDEMLITIIQGHVQRLGMKTIAGPVVLPLVMDTLSGIGVD
LIYGDVIADAQPLDLLVNSSYFAIN
>A0A3P5DSJ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKRTEQVNQQLMERITLAN
EAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYECVLPEDRQHAEKVIRDSL
QSRSPFKLEFRITVKDGIRHIRALANRVLNKEGEVERLLGINMDMTEVKQLNEALFQEKE
RLHITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLLTVLHITFGDNGPLM
ENIYSADTSRSAIEQDVVLHCRSGGSYDVHYSITPLSTLDGSNIGSVLVIQDVTESRKML
RQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAA
GDALLRELASLMLSMLRSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYHFIW
EGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHSERA
VMSLDEQWRMIKENQLMMIAHGVASPRIPQARNLWLISLKLWSCEGEIIDEQTFRRSFSD
PALSHALDRRVFHDFFQQAAKAVTSKGLSIALPLSVAGLSSTTLVNELLEQLENSPLPPR
LLHLIIPADAILDHAESVQKLRLAGCRIVFSQVGRDLQIFNSLKVNMADYLLLDGELCAN
VQGNLMDEMLITIIQGHAQRLGMKTIAGPLVLPLVMDTLSGIGVDLIYGDVIADAQPLDL
LVNSSYFAIN
>A0A024L3H7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLILLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A827RX15|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTACILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLTEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQIC
>A0A6N4KFK1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEKDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A377DSF1|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSAIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIP
VEIVEMGFRVLKKILYPVIFSSDYSAAEKTSGLPFLD
>A0A6N9MVA7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAIAH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376YCF7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIAFCAVLYNISLLFMSRYSVSTWYISRTIEVVSKLTVMVIFMCHIFSALRVTKNIAHRD
PLTNIFNRNYFFK
>A0A234WQQ6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>W7VYH3|diguanylate cyclase|EC 2.7.7.65|Methylibium sp. T29|TrEMBL
MIVKPSRPSPPDAPLPTDGLHLDTALQLLQRAGHALSTGPRDATWLQQLVDALCDLSSRD
ALTGLANRRQFDLALERETDRVARSGEAALVLLLDIDHFKRVNDTYGHAAGDMVLQAVAR
TLQECVRPMDTVARYGGEEFAIVLPNCPPAFAQAAAERVRRAVEARTVPLPQGTMLSVTL
SAGGAFAPPWVRSSARLWTERADAQLYRAKAEGRNRTCIEPTAVSLVSAEERGMLFSPSL
PMPLDDAAATS
>A0A2X1LUV3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFL
LQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGTPLSV
LIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGAMNFIIVLTEASENE
TLRTAERIRSRVEKTKLKAANGEDIALSLSIGAAMFNGHPDYERLIQIADEALYIAKRRG
RNRVELWKASL
>A0A509E736|diguanylate cyclase|EC 2.7.7.65|Methylobacterium symbioticum|TrEMBL
MRLDITTLLIVTFALTFLVGLLFLLSWRQSRDMPALLVWGIAHLAGSVASAGLALRGQIP
DAVSIGLSNTVMIAAYGLIWSGIRSFEGRAFRPVATFAGAALWVVLCLVPAFYEAIAARI
VVASTIAAIYTGHGALMLWPRGREPLPSRRPAALLLTVYAACYAIRVPATLLAPPTELRS
PLDSAWVTVLCLASMLFTLVVAFLFTALAKERAEHRQRVAASTDSLTGVANRRAFFGRAE
ALTATGRPLTLVLFDLDHFKAINDSYGHGIGDTVLIAFCEVACTLLPPDALFGRLGGEEF
GCLLVAREPKAVVAQVECVRQAFAAIRVADLPDLRLRASAGVACGSGIRFDLLMRRADAA
LYAAKRGGRDRIAVADVALKAA
>A0A5C9AN45|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MQHETKMENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLSVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNTSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSNNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGN
IFDPRELALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHMLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLYQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVCASDNA
>A0A2X1KQL8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
KMHIPENFTVSWDYSLCKRAIDENCFFSDEVPDRWATVLRHAILASPHF
>A0A376UAV8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHANRTGT
PLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAFYDNVRSSDYVFRYGGDEFIIVLTEA
SENETLRTAERIRSRVEKTKLKAATARILPSHFPSVPPCLMVILTMSASFK
>A0A482ETT8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MAVADLPTYGYRRVWALLRRESERDGLPVVNAKRVYRIMRTHNLLLERKPADPCRKRAHK
GRVAVAESNRRWCSDGFEFRCDNGEKLRVTFAQDCCDREIIDWAASTGGYDKETVQDVML
GAVEKRFGRQLPTVPAFARLLGLEPCTTAVRSPESNGIAESFVMTIKRDYISIMPKPDNS
CCRSEDIVCRFGGEEFVVFLPNTSVVTAECVAERIRSVIESTVFPNNLRVTVSAGVATQE
DPLGGIDFLLKNADDALYQAKGEGRNKVIVYSAI
>A0A2W6NWW8|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFAAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRT
>A0A5B9AWS7|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTPATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGVRICQLVDNHAITH
SEGHINITVTAGVSRAFPEEPLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRV
>A0A376RGT3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVSTQP
TLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDSNN
YWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRELA
LLAQAMEHDTRGGIRMVSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLWAL
FTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTHQH
PFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILPGA
SLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRRLY
LAKQAGRNRVCASDNA
>A0A376S6J0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKKCDGTLDY
>A0A826N7N0|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQCLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSNMDVLTGLPGRRVLDESFDHQLRNAEPLNLYLMLLDIDRFKLVNDTYGHLI
GDVVLRTLATYLASWTRDYETVYRYGGEEFIIIVKAANDEEACRAGIRICQLVDNHAITH
SEGHINITVTAGVSRAFPEESLDVVIGRADRAMYEGKQTGRNRCMFIDEQNVINRVSAPF
NIH
>A0A2X1KI90|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MEMYFKRMKDEWTGLVEQVDPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFSSNEQ
VERQLKSAMNAGLLTCFLPRLTMSKG
>A0A484X2F4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MCDSAGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQS
LADRRLYLAKQAGRNRVCASDNA
>A0A377K8G3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli|TrEMBL
MIKKTTEIDAILLNLNKAIDAHYQWLVSMFHSVVARDASKPEITDNHSYGLCQFGRWIDH
LGPLDNDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFTAALTDY
KIYLLTIRSSMDVLTGLPGRRVS
>A0A1Q9QWM8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas putida|TrEMBL
MNKALDLTEFHWLLAIVQSIDVGVVVLDRDYCVQVWNTFMENRSGVPPKDAISQSFFRLF
PEVNEDWFRRKLDSVGTLGTAAFTVWEQRPYLVRFKNYQPITGQEDFMYQNTTLFPLRST
DSSISHFCLVIYDVTDVATNRHMLQSANAQLQKLSSTDRLTGLYNRGHWEDSLKVAYARH
QRHGNATSLVMFDIDHFKRINDTYGHQAGDEVIRQVAALLREYVRDTDVAGRYGGEEFGV
VLSDTDKHGAVAFAERLRKAVEELEVKHEGLTIRFTISLGVADLGQPSDSHADLIAWADQ
ALYASKKGGRNQVSVYG
>A0A1S7LI04|diguanylate cyclase|EC 2.7.7.65|Magnetococcus massalia (strain MO-1)|TrEMBL
MALYDALNDRKRIYLLILVMVLVAFVTGGITVGILYQVTVKEAENRLRETAQSQARLLES
IAFQHYESDRSDHFVREHVLRVMRDAHARYQGLGDTGEFTLGHLQNDRIHFLLSHRHYDL
DSPKPVAMQGQDAAPMRAALSGRSGVMVGLDYRGEEVLAAYEPVKYLDWGIVAKVDMVEI
RAPYFYAAKITLLMAILTILFGVLIFYRLTNPILHALHMREQRFSAVAQMAADAILITDQ
SGSILFANGAAKRMFNMQAVDLSQEKLSHLISNEQGQKLLVAEGAGESRPPNDQLVEVEA
CRYKGESFPAEMGISSWNVDGERYFSTIIRDITERKAFQERLRQQAEFDSLTGLPNRALF
VDRLHQALTLTTRSDNKLALMFIDLDGFKAVNDTLGHHIGDLLLVEAAQRISCCVRRSDT
VARLGGDEFTIILTSISEGAFVEGVARKIIETLGETFQLAGQEAHISGSIGISVYPDDAV
SAEELIDCADKAMYQVKRADKAGFRFHGEAIHAQAIRRAELESSIRQALKDGFEIYYQPR
IGIPEGRVVGVEALLRWHHPTQGLLTPERFMPMIEEVGMSVPVGEMVLIEAAKAGRAWMD
MGYPVKVSVNLFADQLKRKKYLYDTVQMALEESNLPPALLTLEISENLLPIDPASPESPL
AGLRRLGVEVSVDDLGQGEISLSSLKRNPLNGIQIRQSVVHDLEGEEKARDLISDLVSIS
SILGLELTAKGAETESQVEILMERKCPEVQGHFFSPPLPMEVMSMLLKEEKDHAPMALRL
ASLF
>A0A1V5K686|diguanylate cyclase|EC 2.7.7.65|Candidatus Aerophobetes bacterium ADurb.Bin490|TrEMBL
MDEINKTDNYKAVFDSLFTGVYFVNKDRVITYWNNAAEKITGYQAKDVIGKHCWDNAVVH
LDMKGKNLCNDQDCPVLKAINDNRLVQEEAYIKHSEGFRIPVDSNISPIADENGVINGAV
EIFTDNLAKVEAFQKFEKLKQLVFIDSLTGVGNRRYTEIKVNVKLQKLAKYAWEKDFGLL
FVDADDFKKINDEYGHEAGDRALRMIARTLINNIREHDFIGRWGGEEFIAVISDVDRRAL
FIIAEKLRALVEETQIEYMDKKIKVTVSIGATIAKRNESIGDLITRADSLMYYSKHLEKN
CVTIG
>A0A485BSE1|diguanylate cyclase|EC 2.7.7.65|Kluyvera cryocrescens|TrEMBL
MKWLTTFNTEKPPAAEMVIAAVPLDFQQYWFGVLAIQLSVNEVTQFLIQSVEGEDDGEYQ
LYDRRMNLIASSEQLPSRRTQLSQEIQAQLAHAYENDNEGSVRQVSRFISWEKLRNFDGV
LLRIHSLDDGIRGEFGSISIALTLLWLLFSSMLLISWAVIRRMVRNMSSLQDSLEWRAWH
DMLTRLYNRAALFERAGKALEKCQHNDQPMAVIQLDLDHFKGINDKYGHQAGDRVLVYIG
RVLMNKLRKHDIAGRVGGEEFCIVLPDTSLEEARIVAERIRESINSREILIGKKQTIRVS
ASLGVCCSEELLRYDFEHLQSIADSRLYQAKKSGRNRVCTED
>A0A2N7QT86|diguanylate cyclase|EC 2.7.7.65|Dyella sp. AD56|TrEMBL
MNTTASLPIPDFLGQLAASVTRARTLEELVRPLLELLQTVTGLESTYLTTIDTDGGYQYI
LFSRNTSRLQIPEGLAVPWEGTLCKRALEEGRPYTDDVANCWPDSGPARELGIATYASTP
VRLDDGTLYGTLCAASGERKPLEDGADQVLQMFSRLIGQQIERERMLQALQHANDTLAVS
ALTDATTGLPNRRALMEELRRRLVAHGPAGRALVVAFVDLDQFKAINDIYGHDAGDRFLS
AIGGRMQGTVRSGDFVARLGGDEFVVLSSPAHDEALAVADALRKRLQEATTGRFHLGALS
LDYAGPSIGSIVSLSGDAEPEALIAQADAAMYEVKRERKQSQPPR
>A0A808Y936|diguanylate cyclase|EC 2.7.7.65|Raoultella sp. X13|TrEMBL
MSDESKKYISVIFKEWLPLYDGLKPEVKAILKNIAAEQSEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAVWVNDILTSEKEQLQALAERQYHIGSIHARIGIPAEAVLRGARQLK
AGLIEYVRDNDKIDHQTGLATIHYAVMAINMAIEMMCHAYTLSHYRATKNEEAYRLYSLM
DNVPMEYGKQQASLSGWENSAIFNIVSENKNDINGTLLSESEFGLWFRHKCVRYFNKNAQ
MEEIADLITQVDNLIIGWKSSDSGAEYKNTQTLLQSIHILCQKISSQLGVIFSSLSQMQN
GKDSLTSLLNRRYLPVVLKHEVTLAMEHELPMTVAIVDIDHFKEINDNWGHMVGDRAIKH
VADLLSNNIRSSDYIFRYGGEEFLLVLVETGAAEAFALLERLRKSISQLPFNVGGETNIA
ITTSAGFAVHTGHPDYNRLLRDADSALYVAKRSGRDCVKMHQVEQDPQH
>A0A7I6QLI9|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP3-S18-ESBL-05|TrEMBL
MQMYLQRMKSEWLLLLEQTEPHIRQQAAEIAADSAQALSAEFYKTVLLDPHAEEFLSNEQ
VERQLKRALEKWIVEVLSCEVADIDRLLKMQHAVAEVHARIGIPVEVVEMGFRVLKKILY
PVIIHGSQPSADKLQIYHFSIHSIDLAMEVMSRTFSFSENSQAKEDENYRMFSLLENAEE
EKERQIATLLAWEIDIIYKVVLDADLGNSLPLNQSDFGLWFNHKGRHYFSGIAEVGHIAR
LMQDFDGVIHAINAATPPIDDKAQRNKFLLQLRSSVSQIIALLRELFEEVSRHEVGVDVL
TKLLNRRFMPTIFKREISHANRVSTPLSVLVIDVDKFKQINDTWGHSTGDEILRKVSQVF
YDNVRSNDYVFRYGGDEFVIVLTEASQIDTLRTAERIRSRVEKTKIAAPDGNDIPLSLSI
GAAMFTGHPDYERLIQQADQALYQAKKRGRNCVELWQASQP
>A0A4R0D7N4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. ANC 5045|TrEMBL
MYQECTHELAEQWKSICEQFKPEDLQATFQFIQAHAEDFVIEFYQQMLLEEHATEFLSAE
MVKNRLKNSLYQWLISSFEVPFQHNYNEIVEKQFKVGDVHARVQIPSWLIIRGVRVIIKK
AFEFFATEANSNLNQFNYLSQILCFATEIMCRSYEMKVEVHNDMKHTYRLFSAMQDVAVH
KDRQRGTLLDWENELMFQVVSDHTKMTQPILSKTEFGLWFIHKAAYAFSSSEQVQTITEF
IYQVDELIQKIGQCESQAQAIEMIQSIRAKNREILHLVDQIFQVSEYISSGNDALTQLLN
RRYLNTIVSREINFSRKNNSPLTLLAIDADHFKSINDRYGHAAGDDALQFLADVILQYAK
GSDYAFRIGGEEFLLLQIDTTIDRALVVAENIRKRVEKATLKTSTGEEFNFTISIGVHEY
DGHPDYQRFFEEVDKALYMAKNNGRNNVSVG
>A0A5D4XZ24|diguanylate cyclase|EC 2.7.7.65|Lelliottia nimipressuralis|TrEMBL
MQRDVYKAKKQFLERLRHHPGKIVNLCFLVVLIFSTILTWREVVVLEEAYISSQQNHLEN
VANSLDRQLQFSIDKLLFFRHSMGDALQTPLGFRVLHDAVTSFNRLRTDPFWQLDVDQQR
TLPISGVSDATVARTTLLARDNQRIGNELSAALEVGYLLRLATSTTGKERRVSYVSRAGF
FLSTDPSPLNHTLISRYYELVTRPWFTEQTERQNRARGVRWFMAPVAGAQEERVITASLP
VYLDHYWYGVLAMDFTLPTMKQLLTEAVDKRTDGEYQLYDSRLNLITTSEPPDGLVNQFD
ERERAQIAHAIEGDTEGGIRLNSRYVSWERLDHFDGVVLRVHTLQEGVNGEFGSISIALA
LLWALFTAMLLISWLVIRRMVSNMYRMQHSLQWQAWHDPLTRLNNRGALFERAKVLAEEC
RQQKLPFSVIQIDLDHFKSINDRFGHQAGDKVLCHAAGLIASALRTSDVAGRVGGEEFCV
VLPGATTQEAANVAERIRACINRKEILVMKSTTTRISASLGVSSTEENGNYDFPQLQSIA
DMRLYLAKQQGRNQVMWRDADKK
>G3A295|diguanylate cyclase|EC 2.7.7.65|Ralstonia syzygii R24|TrEMBL
MSTVIALHEPPAVIGWITKAYARLLLVGFALIPGVLIAYLFYFQDPALKFENHPFHELAI
AAATLEGLFVTYVTWRCYQTSGEPLLRWLTLGFFGFVLIYTLHGAFTGLAHHNIWLFLLY
GPASRLTMSILLLIGLLSYNRPSDHADRRSSPRTWLPWVALFVAIDVAVAYLSYSPIAGA
LAVRLSLEGGALVFSMLNVLVLMSRRIRSPLMVIFGISVTSFALSSLAFILAKPWNHMWW
LAHAIFAGGFFLLSYGVIQAFRTTRSFSTIYSQEELMARLAEAMDRTERALQELQRTNQK
LEHLAATDPLTGAANRRQFIERVETEIARAKRGGAPFSLLALDLDHFKVINDSYGHQVGD
EVLKGFVKKCFDAIRPYDGFARVGGEEFMVLLPQAALDAAHSVAERVRRAIAESAFEIGV
GRSVGLTVSVGISQFGHDGESLDSILRVADERLYRAKHEGRNRVIAA
>A0A1R3U7J3|diguanylate cyclase|EC 2.7.7.65|Agrobacterium rosae|TrEMBL
MQIDLQTLWYLTVGTLLVSASLLLWERQAHPGRARVLDVLAAALFAFVLGCMLAMNRSHF
PVALGMGAINILMMLGYLLVLNAVAGLDGHRYLWSSVAALSFLAIAWAIAGTHFPAAFWN
HVSSVPIALACGLTAWILLRSRTVQRLRSRPIAVSISAVHAVFYLGRAFIAPVLLQRYGQ
DIISIIGKATMYEAVLYSVAMPMSFLMIIREEEKLHLLRMSQTDQLTGLANRHAFFEQAS
RILRERHGDPVSLLAFDLDHFKAINDRHGHPTGDRVLQLFAETAREEAGPEALIVRLGGE
EFAALLPGCDHFQALSRGSAIASRFAKAAARAEGLRIQATVSIGLAAPDCHDLAGMLASA
DSALYRAKALGRNRVETARPSDLEQTRRFFKEQNIPLAQTSRDRLVIEPIIRAG
>A0A7X5YMI7|diguanylate cyclase|EC 2.7.7.65|Brevundimonas alba|TrEMBL
MTARILVVDDVEPNVRLLEAKLTLEYYEVLTAMDGATALEIAAEERPDIILLDVMMPGMD
GFETCRRLKADPVTRHIPVVLVTALDGREDKIKGLGVGADDFVTKPIDDVILFARVKSLV
RLKAVMDELREREESGRRMGVDSDGAGRLRGSGGRVLIVDDNELQSGKMMTHLAGEHRPV
VETDPAAALIAARGPVDLMIINVSSSGFDGLRFVAQVRSSEASRRTPILAVVDPADRPRL
LKALELGVNDILPRPVDPEELMARARTQIKRKRYADFLKEKLDYSLEMAVTDALTGLHNR
RYMAGQLQAMVGRAAQGGDPVAVLVMDIDHFKSVNDSFGHDAGDEVLREFAVRLATNVRA
IDLPCRLGGEEFVVVMPGAALEDAARVADRIRRDIEAQPFPIMGGSEGLTITVSIGVAAS
VAGDTPEALLKRGDEGVYEAKAHGRNQVIARAA
>A0A1F2PL73|diguanylate cyclase|EC 2.7.7.65|Acetobacterium wieringae|TrEMBL
MNLLVYTLQANIYALIILSIIFVNFRKRADLTNASNRFFLIMLKVVMAILILDSIGISLY
GLAGQPIHFLLILLTLIYYLLNPLPSLFWMAYVHYTIHRSEKRLKKLVAVALLPVYLNSI
LSIASIFTGWLFYFGADNVYQRGPLFVMVPICCYFYIFLSFVMILWNRNRIRQRDLLPLL
FFALPPFLAGVIQALIYGLAITWPALTISLLTIYIFIQSRTMNTDHLTGLYNRREFDYYL
EDWMNWHSKKKQLAGFMLDLDRFKEINDNFGHNAGDRALINMSEILRKSFRNTDFIARIG
GDEFVVVLEVDDQKDSMGFWSG
>A0A8F6CXZ1|diguanylate cyclase|EC 2.7.7.65|Methylococcus capsulatus|TrEMBL
MKSPSAGTPDRHASSRSVPDRWNMHKPMLCDSLPTASRTAAAILNLAQSEDVTAEALAQL
IQTDPALTGRILRFANAPAQGTRRPVASVIDAIDLVGLPAVRQFALSLSLIDAHREGRCE
AFDYAAYWQKSLARAVALQSITSQASTVAPKEAFTLGLLADVGRLALATAWPEEYSECLR
KADGEALIALERERFATDHDELTRMLLTDWGFPQVFIDALQLSQQDEIRDEGRTGRFARQ
LALAQHIADHRLAEKPRRAALSPLLRAEARRCGLGDEDLARLLADPPADWLDWTRTIGLP
GDAPTGGAEPSRPPPQTDEKLHVLLADDDPIMLARLSRQLEADGHHVASRRDGETALAYA
LEHQPEMVITDWHMKPMNGLELCRALRESALGGNVYIVMLTASESEDALVEAFGAGIDDY
VIKPPSVRVLKARIRAGQRIITLHKKLARERKEIERYSSELAAANRRLELMAHTDQLTGL
PNRRYAMDRLEREWAQARTFGRPLSIMMLDLDWFKSVNDSLGHDAGDQALVHAARVMRET
VRTSDVVCRMGGEEFLIIIPDTAGPAAIQTAERVRSAVEQQQPAKLKLSRPLTASIGVAD
STSAPSLKDLLLKADNALYQVKQNGRNGVRYAGL
>A0A8G0TGC3|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MELRGLLRLLLLLMCMPLLAYADRLAMANVKPAGQDVSVTQTVRYCVDPDWLPYEGIREG
KHLGISSDYIDYIESHSSLKFQLVPTSSWTETLSFLQSGQCDLTPMLNKTLIRETYLHFS
DVYFRSPNVLVSLKDQPFLQGFENIGARTLAVPKGYRLAEYIQHYYPQIETLTVASEPAG
LQSVLDKRADLFVGSMFSVNSYIQQTGFNHLKIAGWGGPEDELRMGVAYGQESLLPMVNK
ALNAVSEQERITIYQKWNNVTVIDETNYSLVYQVICATFLLLLILGARTYFISQYNRRLT
DKNQQLETLRQQLETSNAELEFLSTHDPLTKLYNRHYFNRLFINNEQHDKSAKAGMCLVM
IDIDYFKEINDTLGHNVGDRILEQVSQVLQHCVRESDVVARWGGEEFVILCQQSSLPLVE
SLCVRIAERIKHYQFTDNVQLTCSFGVAKLADNEPMMLCFERADRALYRAKAQGRNQMCT
DR
>A0A8G0TIR6|diguanylate cyclase|EC 2.7.7.65|Shewanella putrefaciens|TrEMBL
MIYSFRNSGFRDPETGVYNQTYFMEVFNREWHRHIREHQSLALLYLCPHIHETVKQPHLL
EFFTKQVQEALLRATDLIARLDHNHFALGLFNIDEEGAEVVLKRIEQQISDFNQNFGKNH
KLTIDYKLAACICLPTQENKIESLFSNVSQLSQDLEKNHDQSQALIRLQ
>K9DEA0|diguanylate cyclase|EC 2.7.7.65|Sphingobium yanoikuyae ATCC 51230|TrEMBL
MFTDEERIKGSAKLPAHSRHSHAPLKLLAEMAAEHGRELVALFYDTLLRDQEAAQFLNHA
VVQERLSSSLIEWLTQLFSGQDIRDSPEKQARQKIIGEVHARIKIPVHLVMTGALVIKTR
LAELLQGQAVDPLVGIRALQLADARMDTAVMLISQSYVKDTTARARLDEAYRLFSLDQDA
AVDKETQRASLMEWSQNTLFALLQAGPGGGLLRLGDSAFGLWLRHRAQFMFEQSAQFSTV
VRLVERIDEMLLPELVAPRKRQDGSSALADLRAAVDEISFLVADLFQTLSTMEGGRDPLT
RALNRRFLPAILGREVTFAKENGTALSVMLVDIDHFKAINDRHGHQVGDEVLRQVAQVIV
GNVRATDFVFRYGGEEFLIVLVETGIEAAANIAERIRADMEGHIFETGSSGGLSVTASIG
IALHSGHPDQKFLIKAADEALYRAKAAGRNTVELAPIYGEGGKGIWPLAT
>A0A1C6KZ57|diguanylate cyclase|EC 2.7.7.65|uncultured Blautia sp|TrEMBL
MEKSVKDNPEYKMKRQGMIIGLVCLAVMVFLTIFLMSRYRQRTEKIFTELMEESLLSTHS
EALTEMENFLAGSTGADKVEEAWEALNEDEGNVLHYVCNSDGKILAGDMRIFDIEYTVAT
VLHSQHVKDNSISQVEKSLKKLTYGAPHIFTELEKTDIYLVASKLEGRDCILFSEYRSAK
MKNYKAVLINGNRMIIFTLLGCALIMLLFTVRFYMKQQKKVMKGQARYDILSEFSDTVLF
EYDCLEKTLVFTPNITTLFGLKEIGPIRPFDNDTDFTMVHPDDVAKVKALLSSIGDNSDE
IDDFVIRFKDKNDNYRWVRWMGRLIRGRLGTPQAFLGKISDVQDEMTREQDLREKASVDG
LTGALNRKAAEQKINTLMQDKECKGYLLMLDIDDFKTVNDTMGHAIGDLALITLVKLLKE
HFRREDIVGRLGGDEFIVFMTNTELASAVEAKGAEILDILAKSETTPHFTVSIGAAAYPA
AGNDYESLYLAADNAMYASKKSGKNRIYVDNGQQKKE
>A0A4Z0XYQ3|diguanylate cyclase|EC 2.7.7.65|Caproiciproducens galactitolivorans|TrEMBL
MKIRKYLISLLAAFSIVPVLTVMISSISLFQSKTAEFLQKNAESEATQAADIVDQFFAQR
KSSLEVTADLPGVKELLFFSNEGRSESELEPYRQMAINILKTMTSRQTAIRDGNSRGNYV
KRSCLVNRENIVIASDDSEIIGTRSTIGENMRELSADKMYISNIMKNPIFLQGHKYFEVA
VPIFSGSNYEGFIQSTIDMTYFDQICRRAFMETGRTFIIDPMGNIASEQFTDTDGNTLDN
IKCMNGNSDFYQQLQKMDLEKHPSGAIFYSVNGENKCGYYSSVAGDRWIVVSAVKQEELL
HPIRRIINIYIILLLIFIILMIGFSCLAANRFLNPIRDMSAAFVKVEQGDYQTQLSGTYK
GEFAEMASSFNHLIEKIKEDTDVLKLNETRYALIMEETNQVVFEWDILLNQIYHTVYWTN
KFGFSAVEEHPDSEIPKFRQVHPDDQIIMDDLFRSILQSKQPGPVDVRMKDISGKYIWCT
VNVKALYDKENKPYRAIGLITDTDRQKKKIQQLENKSQMDLLTQLYNKVTAESLIKKHLK
DCSRKLLQGFIIIDIDNFKSINDMLGHIFGDAVLKKVATEIKALFRATDVIGRTGGDEFI
VFMKDLDSRELLSQKMKEICEVFRNAYTGEDGTYKVSASVGGAVFPDDGTTFAELYRHAD
EALYDAKDSGKDSYRLYSGALMEEAQ
>A0A6S6XXG6|diguanylate cyclase|EC 2.7.7.65|Denitratisoma oestradiolicum|TrEMBL
MKFLRGLYFRLLMLGAAVAAIAVLSFGYYVAAEQMKMEVTTHERELQLRAAGLAAAANHA
VLARDYWEIEQLLRQAISDPSLLEIQISDDKGHVLGNIGRSLIDATPSLIFDTPTITTPN
SENNPQMRRRGDLIEVWSPVVLDKTVGWVRLESSQAGSRARHRHIWRDSLIVALSVLVAS
ALMLGWLLRGPVGALGAATRFAASLPLNHGHQLDTHPSITEVDGLIDTLNQTSRQLAEQD
EALRKSQRHLEIRNQVYERLALGSELQEILSLIVSGLESERPQWLGAILVLDGDGRHLRL
GAAPNMPESYLKMVNGLEVGEGMGSCGTAVYRGERVVIDDIAHHPYGLQFRDLALQIGIV
SCWSEPIRSSRGDILGTFSFYQKTPTRPTQEDTEAILHGTHLASVALERHLTEEELQLAA
SVYQASGEAIMVSDGGNHIVAVNPAFVRLTGYSSQEVMGRSPAILGSGRMDKSFYSAMWQ
ALETSNRWQGEIWNRRKNGEVYAEWLTINVIRDHEGQPHRYIAMFSDITAKKQAEETIWQ
QANYDQLTGLPNRRLFRDRLRQDLRRAQRQNGALGLMFVDLDRFKEINETLGHEAGDKLL
IEAAQRINSSVRDTDSIARLGSDEFAITLLGLVEPNEMERVAQAVLLALSQPFSLDTEVG
YVSACIGITLFPNDGLDIETLLKNADQAMHAAKQAGHNNFSWFTLDLQLAAQVRRTLIND
LRGALAADQLRVYYQPIIDLQSGAIVKAEALLRWQHGSRGLISPAVFIPLAEEVGLIEEI
GDWVFRTAARQARTWHDQGHTLQVSINKSPRQFGGDGSGNTWLAFLKELNLEPRQLVIEI
TEGLLLDQRSTVTEQLLGYRDAGMEIAVDDFGTGYSALSYLQRFDIDYLKIDRSFIKDLT
ESADDRALADAIIVMAHKLGLKVIAEGVETAPQRDWLIGAGCDYAQGFLYSRPVPVDEFN
ALLRRG
>A0A853W6Q7|diguanylate cyclase|EC 2.7.7.65|Moorella thermoacetica|TrEMBL
MSFDISELLTLYDVVTFSFPERYEDLMREIIEKATRLFGVRRLAIVLREGERYKCIERWG
FRRDEEVLERIKNGGENSFIYLMRNGEQGLLYIEPPGRISEREKRLYTIFARRIENIIAR
KQIEEKIKNSEQEKKVILDSIVELLVFQNPDNRILWANRAAAEYAGARSGELAGRFCYEA
LHHRDEPCEECPVIKALDTGVPQEGIIASLEGRQFFVRGYPVKGENGLIEGIVEVSVDVT
ERMQAEEAFRTIFNSVHDAIFIHTLDGKIIDVNQTMLRMYGINSKEEAIKLSIIDDYSIP
GSTADQLPLLWEKVISGENLLFEWKARRPVDGSVFDVEVFLKKISLNKKDVILATVRDIT
ERKREEELLRNLFTHSPIGMYIVSEGKFQLINPQFEILTGYRQDKLIGMESLNLVVPEDR
KMVRSNAIKMLKGEAVEPYEFRIVTGQGDIRWMEETVASIWHDGKRVTLGNIIDITQKKK
FEQKLAYISLHDQLTALYNRAYFEEELKRLSTSREYPITIIVADVNGLKLVNDTMGHDKG
DELLTACARVLKKAFRSSDVVARVGGDEFVALLPRTDGKTGKSILKRLRLSIDKYNEEHP
ELPLSVSFGIATADTPEQSLKEIYKKADDLMYQEKLNLGSSARSKIVNALLTALSERDYI
TEGHARRMQKLCQDLGEKVGLSAQQLANLSLLAQVHDLGKVGIPDRILFKRGPLTEKEWE
VMRQHPEKGYRIAMSSPDLAGIADLILKHHEK
>A0A6S6XNE7|diguanylate cyclase|EC 2.7.7.65|Denitratisoma oestradiolicum|TrEMBL
MDDIEQDPKGVAPGHPGMTPAPEPQGIGDRFLFDASPFGIFVIDHTGSVVDCNPIFLSIT
ALPREKLIGFNPLGSPRGRTTLGAHLRRALAGEPVDFETRHAFIPGGKIHQCRYVLQPIK
SGGSEFSVLGLVEEIGRRKKQEQAVLKATKTLKRQLASETARFRGLVDQSLAGIYMIRDG
QLVYANQMLAQLYGVPSAAAFIGTSVFDLVAPESRATMQEYMTRRLTGDISDARYEFIGL
RPDGGLLELEAHGRVVEIDGQPTIVGVIIDISARKALERELNYQALHDDLTCLPNRKLFF
DRMNQLIRRARREASRFAVLFLDLDGFKTINDCHGHGSGDQVLCQVARQLSACLRESDTV
ARLGGDEFAILLPAINGPPDVERVTDAIQARIALATKELGIPEPISASIGISLYPDQGED
ADRLLALADQAMYRAKSQGHGLVCFAGAGEK
>A0A376DDM4|diguanylate cyclase|EC 2.7.7.65|Edwardsiella hoshinae|TrEMBL
MIDVLDMDIAKSFILNFPGIISVRDSHHKIVYVNPPFLDWLKKITDINPIGFTNQELGKN
FDAGTAELFAQCHDLEIAYKFNEKINNRIINYKDKTGRLCYFDILKFKVCINGEDYIFSI
GKDVTDMYSKLTLYKHKAARDVLTGLLNRSALDEIGVFNNSVFIYIDLDNFKKVNDCYGH
VTGDNILVRFSQLLLKVFSVSNGIVARIGGDEFLVIIKEVASEANVKNHLREVRALFNAE
FGDYTGIGFDFSLGYCRFSHSIEHTLVEVDGLMYKDKSEKQC
>A0A1V5SRR4|diguanylate cyclase|EC 2.7.7.65|Candidatus Omnitrophica bacterium ADurb.Bin277|TrEMBL
MANERGEIKNRKILLVEDDLDFANILKIRLSKEQNPSIEITIRQTLKDALLMIRETEYDL
VLLDLMLPDSTGIDTFSKVKTEARHTPVVIMTGLDNDQVAINAVRRGAEDYLVKSDISSR
LLMRIIHHAIDRHRIKEKLASVTGRLRETNLQLEKMALLDPLTELYNRRGLQQVFSREIQ
LGIREGHRPLVLLLDVDDFKKINDSLGHPVGDILLKEIAKKIRESVRISDHVARIGGDEF
ILLLPKTSLREGIHLAERLRMAVSGTKIHVSETETLGITISMGLTSIHGDITSVDELLAI
VDPLLRQSKRKGKNRVTCDEQGPGQDGSMTTSTFSEKFSAVLRRGTDFFALKQPIMNLAD
LSIIGYEFLSRLKSEGVCMPNDFFRIAREQNLLTLVDHYCFRSCVAASAELSPELHRHIN
LFPATIVDISPEEVIGKLSVSCPAKSYCFEISEQQILGDPSHLIGPVEAFKRYGVSIAVD
DVGFGNTCLESLILLEPDVIKLDKKYVRGISQDTHIERTFRRILKVAEDLDAEVIAEGIE
TQEDLDILRNLGVKYGQGFFLGLPA
>A0A0F1B452|diguanylate cyclase|EC 2.7.7.65|Enterobacter sichuanensis|TrEMBL
MQRDTFVVRQSFLQWLHKRSNPGLIVNLCFIVVLVFSTLLTWREVVVLEDAYVSSQRNHL
DTVASSLDRQLQNSVDRMLLFRQGMRDAIQTPLAFDALQSAVSRFNTLRILPTWQLAVDK
KRTLPINGVSDAFVEKTTLLNRDSERISNEISAALEVGYLLRLASSRAQTESRVNYVSRA
GFYLSTDTPEQAGDITSRYYHLVTQAWFTEQSERNNRARAVRWFISTPSAWTGDERAITA
SVPIYFDHYWYGVVAMDFTLGTMQRLLADATEDRTEGEYQLYDTRLNLIATSAHAGNPVN
HFDERETAQIAQAIEHDTGGGIRLGSRFISWERLDHFDGVVLRIHTLHEGVQDDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYTLQHSLQWQAWHDPLTRLNNRGALFDRAKMLA
ETCRQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHTAGLIATGLRKNDVAGRVGGEE
FCVALPGISLEEARGVAERIRCRINSKENLVKKSTTLRISASLGVSSADEKGNYDFEQLQ
SVADARLYQAKQTGRNRVVWRDQERK
>A0A7R7AGN6|diguanylate cyclase|EC 2.7.7.65|Methyloprofundus sp|TrEMBL
MLLQTSKLDTPFKVIVTAILFYYAGKLAMPLVSPANFSGTIWPPVGIGLGAVLLWGNRVL
PGVFLGDIGVKLAIYDISILEMTPDTLWVIGLMALNGVLRAWLGAYLVRCYANYPNPLIE
LKEILRFFLLAGIVATFISSILNVLALYLLDLVQTEDILLAILNWWLGDSMGAIIFTPLF
FLFFAGQELHWRRRRISVGVPLVTLFVITVVAFQFIKNQEDQRLQIVFTAFGQQFQTAFE
AQNAKYQEQLLFVKHFFESSEDITEHEFKQFTQALFSNKALQSMQWVTLAGNTDKFTLKY
QVPAFSKELSAKSSEFNQTLWAGFVANKAQKIHLSRAGDYTQATQVLIGLPVYKAQQLIG
LVTANYALDTMIEQLSEYRALTDITLQVKTVNQQGKVLFQSNKPYDLKGVLALAYSFIAQ
QQLYFLLLPNESFIQQHYSAIVWWTSVAGMIITSLLTIVLLMISGHTEVIKKEVNERTKA
LQVSNHKLAESESQFKELVQAQSAIVWRYDPIKQVFTFVSDEAEKLLGYPISRWLTEVDF
WPNCIDERDREWAIKFCIDQTEQHKGHEFEYRMIAADGRIVWIKDIVNLKIESGEVTELL
GFMLDITEQKQSESIIHNMAFYDHLTSLPNRRLLMDRLEQEIIIAQRHGHYGGVIFLDLD
HFKLLNDSLGHHIGDDLLVQVAKRIQVAIRSEDSAIRLGGDEFVVLIHANSNSLKEAAEH
GLIVAEKIKKSLAEKFMLQDYQHHISSSIGITLFPEDAQSINTILQQADTAMYRAKELGR
NRISFFHPSMQFAADARLQLEKELRLAVESGQFVLCYQPQVNELGELISAEALVRWVHPE
KGHVSPANFIPVAEDTSLILPLGAWVLAEVCRQIKEWQQQGLVINNIAINVSSKQFRQKD
FVQSVQNIMEESGVSPDLLEIELTERVVIDDIEDTVQKMQALKALGISISIDDFGTGYSS
LAYLKQLPVDILKIDQSFIRDITLDPSDAVIVETIIEMAHHLGLLTVAEGVETAEQVAFL
SEQGCDMFQGFYFAKPLMSADFYKKFVG
>A0A8E6KLX5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Paratyphi B str. CFSAN000540|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWSAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTAGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A377Q6L2|diguanylate cyclase|EC 2.7.7.65|Iodobacter fluviatilis|TrEMBL
MEFWHVFYKNQTIKMFRVFVFCIVFFLSQAWADDASPAFLVQPDSSGTYINSKLEYFVDT
SETMTFDEARSHADFVSAGGRNVLARVRHPIWFRLKLERGADAPARWWLDYQIFSPVELQ
FYSPDQNGQYIKQASKKYEPFSAHPSYGRPFFYPITFNDQQSMVIYWRSVSHSAFIFPVR
IWQQEKWIDLTLTEYLLYGLLLGIMFGLSVYNLFIYLRIRDSMFLLYFFAIVSYMFYSVN
INGLDLNILWSTSFHRFKGLSSCITATTGIFSVLFAISLLGNLKRRKWFSYTLYGVVAIY
LSAIGLVFAGQYSWAELLTQWAGGVWLPLVLGMSAYLSYLGSVWARCYLIGEGPTLVGST
LLVLLTQGVIEADRFNTTFYFVAGAWSAIMFSQALAEKVNSLKKAATAALNMAVTEKTAR
LKEAAQYQISLEEKVKQRTKELSLEILLHQQTLEQLRESQSKLEEMAYSDVLTGLPNRRM
FQDRLLQAYTRAQRQDSPFALALIDLDHFKRINDSLGHGVGDQLLQIVAQRLNAALRHSD
TVARLGGDEFAMILTAPISRDDAISICQRLLSSFDAPLLIENHQVQTGMSIGLAWFPDDG
RDMDELIGSADVALYQAKAAGRHRLSYIGHVTGSNLHQ
>A0A090EG52|diguanylate cyclase|EC 2.7.7.65|Mesorhizobium sp. SOD10|TrEMBL
MTARILVVDDIPANVRLLEVRLLAEYFEVLTANNGPDAIETCENGKVDVVLLDVMMPDMD
GFEVCKRLKSDPATSHIPVVMITALDQVSDRVRGLEAGADDFLTKPVNDLQLMTRVKSLV
RLKSLTDELRLRASTTRNIGIEELLSRDFATQDAKPRVLLIDERKSSVERIQKMLRNSAE
LDVATDPNAGFFQAAETPYECVLISTAFSGFDALRLCSQLRSLDRTRFLPIMLLADEGEE
GRILRGLELGINDYLIRPIDQHELTARLRTQVRRKRYNDQLRASVAQTIEMAVIDGLTGL
HNRRYLDSHLQTLFDRAVARRRPLSVMITDLDRFKSINDTHGHDGGDDVLREFARRLRKN
VRGIDLACRFGGEEFVVVMPDTDGAVAEKVAERIRAEIAQAPFAVGNDGKTIEVTVSVGV
SSLLKGSDSVAALMKRADLALYEAKSGGRNRVVAKAA
>Q8EIB5|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MANDDWSDGSYFVEHAKLLAALLDSLEDQISVIDRNGVIQFTNLSWNRFAEQNGMPKGHN
WIGTNYINVCASSDEPLALTAMEGIRRVIQHDQERFYMEYPCHSPDICRYFMMRVVAVKG
LVPEFYAISHVNITERKLLELEIADLSEHDPLTGLANRRLFTRFLHNEWRRSQREQTPLS
LIMLDLDNFKTCNDHLGHQVGDDSLQMVGRILKSFCQRPADLPCRFGGDEFVLILGNTDR
ENAQHIAGEICRAIKTLDFVIQDDIRLSASIGVATLYANLGESETQLLTAADAALYVAKR
SGKNCFHGVHSEPSFTE
>Q31ZX9|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MKTVRESTTLYNFLGSHNPYWRLTESSDVLRFSTTETTEPDRTLQLSAEQAARIREMTVI
TSSLMMSLTVDESDLSVHLVGRKINKREWAGNASAWHDTPAVARDLSHGLSFAEQVVSEA
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
NAYEVELWIPTCKGQRLFLFRNKFVHSGSGKSEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQDLIDHAINHADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
LSCLEHDQVLARPGGDEFLVLASNTSQSALEAMASRILTRLRLPFRIGLIEVYTSCSVGI
ALSPEHGSDSTAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
ELALSVIQQFSQLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
A
>A0A1S8TUB6|diguanylate cyclase|EC 2.7.7.65|Clostridium sp. BL-8|TrEMBL
MKKIMNIIVLIALLLGIYSFFHMRKVTNLQAINGNMYLDKYDFAGQGIINLDGQWEIYNN
ELLTPEDLKNRKPDEYFTIPGNLKEQLRENNAGYMTLKLEIEAPKDVIYGLRIKRLLSAS
KLWVNGIVQGEVGKVGKSYEDEKAIYLPIYSYFMPEDGHIEIVIQTSDYREVFPTIQSME
LGLKDQIINESLIASGIDFIIFGGLLVIELIFISLYKRMPNKKSYLFFVILCLFIQLRCL
FLNERIIVHFFPNMPFELLSKTAALTYYLWIPVYVFFIKDVFPNMKKRIVIISSIFSIIF
GGICLFTNNTFYDRLSVPGEIIVIIIAADIFAFLIKKVKEKEQNSIISLIAFGGLIITGV
NDMLVNNGLPYVGRYLFQIGMFIFVLLETYSLTLNYTYQVNKTKILKEKNKEIYEKSIRD
GLTNLYNRYYIDKVLDDMMDAYIESGDIFTIMMIDVDFFKHINDTYGHLCGDKVLIDISS
YLMDNLRKTDFIGRYGGEEFIIIFPHTKIQEAKKIAENIRRNIEALQIDDDIRVTISGGL
YENKTQIKQVAIQNVDKLLYLAKERGRNRIEVMEEEEESRK
>Q8EJ99|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MSNDQSAMNELHWLIDMVQTIEVGLVVLDRDYNIQLWNGFMENHSGVSPNSIKGQNLFSR
FPDLPATWLKQKMESVFMLKNRAFISWEQRPYVFQFKNYRPITGRADFMYQNVTLLPLAS
LTGKITHISVIVYDVTDIAVNKLQLKAANEQLERLSQTDGLTQLHNRRHWQQCLEHEYDL
YARYSGIASLVMIDIDHFKNINDTYGHLAGDKVIQHIAHILSHSLRETDCAGRYGGEEFA
VVMPSTCGADALNFTERLREKIASSTVVYEGLKIKVTVSLGVCELGKHISSSSSWISCSD
KALYEAKQKGRNCTVLHCAPTSAE
>Q31Y76|diguanylate cyclase|EC 2.7.7.65|Shigella boydii serotype 4 (strain Sb227)|TrEMBL
MKASLDEKSATGWPPVCFAMRINLLFVCLKTPISESSVLMFVEHNLIKNIKIFTLAFTLT
VVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFGWRGVVPVLCGMFCTNLWNFHL
SFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRYVWQRLFWLGLVTPIGIKCSMY
LVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYNMLFYYLTRMIVSPHFAQILWR
RDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIAGYLVPVFFIIFTLGVGKLRYP
FLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLISFSVCLLYMVRIYHRSEWLNRR
WHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSICR
TLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAW
GRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQ
GDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLK
WLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAE
SSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVR
SITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYLIGRPQPLAD
>Q8EJC2|diguanylate cyclase|EC 2.7.7.65|Shewanella oneidensis (strain MR-1)|TrEMBL
MDLLLIDDDEVDRTAIIRALRQSKLAFNVVEANCAFDGLNLALQRHFDGILLDYLLPDAN
GLEVLIKLNSMTQEQTVVVMLSRYEDEKLAQRCIELGAQDFLLKDEVNSRILSRSIRYAK
QRASMALALRNSHEKLKELAEHDSLTKLMNRYGFELCLNRAIARVKRSNDLLAVILLDLD
DFKAINDTLGHQTGDILLVKVASRLSTVLRDGDVIARLGGDEFVVLVTDNDYKYFPMIVA
NRLLKAFEEVFCLGDNDVMIGASIGVAFYNEAASDSSELMKCADIAMYRAKKMGRNQIQF
YSEALDKEVRYRNHIESSLRIALRLNQFKVYYQVQVDAQTHQMVGMEALIRWLHPEDGLI
SPDQFLPIAEEIGLMEEIGDWVLFETCRQAQYWLNQLAPTGHSFTIAVNLSASQIGHVDL
YEKIAHVLKVTGLTPGALELEITENCLIEEPHEHAKILDKIAQLGVRFALDDFGTGFSSL
EHIKLFPISVLKIDKSFIASYDKDEKDTRLLSALLNFAYGFNVTSVAEGIETLEQAEFCT
VRHCNLLQGYLFSRPLEASEFEAKYITPLLSKL
>A0A8E7RAC1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Stanleyville|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPSDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A379BK25|diguanylate cyclase|EC 2.7.7.65|Nocardia brasiliensis|TrEMBL
MLSYCARQETGTNLVGVHKQTGDSLADVRAVALVTSSRSMVRSWWRYRVDYRWLIETFEA
HSALGPLKFMMGWGGIVMGSITLLALASQGGQRGVAGDIQAVVVAVTAALWTLRWWLFAW
PRETESLMWVAVVDIAVTANNVMVQDRLLGAMGCVLLVTTGGYITIFHGPPVLALHVGFA
VLSILALAAMMVAGGPGGSGHGRGDLALGAMVVLVILVVTGVVLPVVQFCNWLLRLDALS
DPLTKVLNRRGLDSHLTRLFRARGRDHGVYVVTLDLDRFKSVNDTFGHSFGDEVLVRTAE
CLCAAAPPGAVVVRTGGEEFVVVGRLHGADLGAVAERLRQAVESMPRLPQTITASVGAAR
IDPVHTGDSRRVPIDRTVFHTADSAMYRAKQLGGNAVVIAEPVPRPESARRETPERR
>A0A1H1FEW4|diguanylate cyclase|EC 2.7.7.65|Paraburkholderia tuberum|TrEMBL
MRLPSASKTPAKTVWDRASSRPRHTVILCFAVVFVVTLILAVHQYFLVRARELDNRSHQL
EIQARVLDVAVRNNRQHLQFLRESAERLLADRTAQLDRTPDASLQAVLRAQDERVWNLQV
RDIDAPIRGIGTQQLAVTPGLHRDEPTFVEDLRLAQLMSRLFAVQFQMGTGLERAVYVSP
TGIVVAHPTIDDDEVVRLLQMYGSSRLLQLANQNPLDYDVTFDPVRGRKNPAGPRLLFGT
AVMSNDVVRGLIFFVVPQRIVQDYLWNNTTADETHALIDPSGMPIATSGSTFSVNDENWL
KTLPAQWNTLSASTLFRTPSGTLSAGQDFLLFRKLDTADLVLTDYVSAATVFFSVVRLSS
ALFAGVWILMALLLWATLFVVDQLLSTQMALNGRLRELSLADPLTGLANRRRLNEEFDAL
SRRNDERRIALLMIDIDHFKVINDNWGHAGGDEALKHLANVVRIAVRPGDLMARLGGEEF
CGLLPDTTADDAARIAERVREAVARNACVLQETQLTRTAPGREIWFTISIGVAESVSDNC
FDLEGLIAVADQRLYAAKASGRNRVVASESMQS
>A0A178X149|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MFATVVLVDLLAAMLVLWWLWIEPPVFADLGRSVLITVGGLFSAELTWRLERQRRQLTDT
PHVNMSSVAILAVTLVSGPVAGSMAAAVLYLHLWWRASRWTSGIAPYRAVFNTSAMIISA
CVSYGVVRGVSSGNVLSAPSDVSALVLLAAIATFWLVNTLAVGAAIATAEKQRSIAGIVG
GWSANALEIVTLFLGAVTAVFVELRPWLALFLLPLVYVLHRSDSVKHLEIAASTDRKTGL
LNMETWRCLAEAGLRKARRHHVPTAVLMLDLDFFKRINDTHGHLFGDDVLRAVAQVITSE
TRRTDLVGRFGGEEFVIFLSDVNLGGATEVAERIRCAVAALEIVPSEGSSSSAVPVRVTV
GVACDNGYGGDEVDLSELLLSADNRLFFAKGQGRDRINAGYTRQAR
>A0A178X4J5|diguanylate cyclase|EC 2.7.7.65|Amycolatopsis sp. M39|TrEMBL
MVSTWPSPSGDGQCCAACGQPLGSWGMDKYTGLLNREGWDARVASALDGSMGHAIALLVL
DLDHFKAVNDRYGHPVGDAVLRVVAATLAAAVRREDIVGRYGGDEFMALLPGANRACAQA
IAERIRKRIRNAVVEARPADGCPVVITELTASVGGVALSASGGTGIAELVRRADANLLNA
KRFGKDRVLIEDDGSPPRTSCRPKLR
>A0A8B3U7J7|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MLMYDAVTTNWGIASVVINLSNMVFIVVVAVLIQRDRRLMKKTPDPLNALRLFNYCLIAA
LLCALLGAVGSVGIDSHTFWPLFADWFSEQFSTGVLVVPCMLTIGMPVREFRLRLEQLLP
VIALIVSVVASVVIGGAGSLSFPLPALIWCAVRYPLPVTCLLTFVTGAIEIILVANSVIN
IAVATPLTTPMMFSARLGIATMAICPVLVSVSMAAINSLIRQVSLRADYDFLTQVYSRSG
LYEALKHEETHRHSRFLTVMLLDIDYFKSINDNYGHECGDRVLASFARQVQQVVGEDGMV
ARMGGEEFAVVVNSGDARHGYELAERIRTTVANHPFTWRQQTLSLTVSIGLGSGKAEAWQ
LTEVFNKLMTEADDHLYRSKKAGRNRTSARVADEHITAATGHETELR
>A0A155UY62|diguanylate cyclase|EC 2.7.7.65|Enterobacter roggenkampii|TrEMBL
MSQNGFEALNVIKTPVWLISPVSEEIVFANVVATQLMGDKTLDQLRKGIYSANAQALLSM
YVPELKTEQEIVEIWTIRSRDGLDTPLSCRLSLARYAPWGDVIVFEGIAQHILSGLKASR
SATYRRKKQGFYARFFQTNSAPMLLIDPARDGQIVDANLAALNFYGYSHDGMCSKHTWEI
NTLGRDVMPIMTAIAALPGGHKPLNFVHRLADGSTRHVQTYAGPIEIYGDKLMLCIIHDI
TEQKRLEQELEHAALRDSMTGLLNRRQFYAITDANNLNNRPAQQQFSLLLVDTDHFKNIN
DLFGHLKGDEVLIALSRTLEACSRENDMVFRWGGEEFVILLPHTSLDTALQIAESIRAAV
ARITIPGLPRFTVSIGVARHNPGETIDELFKRVDDALYRAKNDGRNKVLAA
>I0KXZ7|diguanylate cyclase|EC 2.7.7.65|Micromonospora lupini str. Lupac 08|TrEMBL
MEVADPRNSVPPGRVTPFAAFVVGILVVAALTATGPLTTLPDELPRLPVAFWTMAALAVV
CDARPFVPPGRRQTSAVFPSTCFTFAILLGWGLGPAVAVQAVGVIVSGWRMRHAAWRTAF
NVGQYACALAAAYGVIQLGPGTVFSGGHLHVTDVAAVGGATLAWFVVNYGLVSWAVRLRF
GDRWWPTVRQGVGFELLSTGSLLLLAPVLVAAARLSAALIPLVLVPLFAVYRMARLTVEQ
QHLAAADPLTGLPNRKALLAEVAEQVHLHAERTARGEPGGRLALLLIDLDRFKNVNDALG
HAVGDRLLVEVSARLTDVDPRPQMIARLGGDEFAIVMTGLTDVGQARELADRVVGALAEP
VPLDGLPLDVGGSIGIAIFPEHGEDFATLMRHADVAMYDAKHRNDTVAVYAPESDHNSAE
RLGLLADLRRVLESGPSAAGPLDAAPPQSQAEHTSQAEHTSQAEHASQAEHAGQAEHAGQ
AEHASQAEHASQAEHASQAEHASQAEHAGQAEHASQAGRVNAGRADEGGRVDAGHADEGG
RVNAGHADEAGRVNARHADEAGRVNAGHADVAGRVNAGHADEANRTNAGRGKSAGSERTA
DVPLAVEAEVRGGDGAALPAPTAAEVAPHPGGAPVIAAAPPAGGRWWGRRRRAGGDLAHA
DELINRIATGADPIRGRNSRATIPGTRPGPLRDRRAGGQGRRSPNGGAVPPPSGGRPGRD
GLSVSESEAIEPTGWVRDDGESVDDAGEITMYYQPQIAIATGEVVGVEALLRWRHPRRGM
VDPEELIRVAEQSAVMRLLTRRVVDDVVEQLAKWSAAGIGLRAALNVSVRDLHTGEIADQ
IADRLARYGVPAERLQLEITEGALMADPRRVLATISRLHRIGVAIALDDFGTGYSSLQHL
RRLPLSEVKVDRSFVLGMSEDADDAAIVRSMIELAGALGLRVVAEGVEDERTWRMLYAAG
CDAAQGWFYARPMPAEQLVTWLARYRPVRPTGGPEPEAGRRSTR
>A0A143PTN5|diguanylate cyclase|EC 2.7.7.65|Luteitalea pratensis|TrEMBL
MNLALGLPRLPRAARRQLASRTALHAWLLDLQRPATGAALARFLVPRLSEWLPLQAWALV
IPGPHGPERVGPAPRGRRLGPAVLAVADAALRAQAPWSAGSMRAVLRTGPDAAAVAWPLR
GREEVAGVLVGIDNTPAPRPPDVVRAGEALWRDVLEPIGLALARVRHLDRLEELATIDDL
TGLFNARHLQHTVERELSQLARTGRPLSLVFLDLDAFKRVNDRHGHLLGSQTLVEVGQLL
RACVRLTDTPVRFGGDEFVVVLPGTSRRDATGVARRIQQRVAAETFLSGRGVEVRLTVSV
GVASLNRPTYSAAELIRTADEAMYWVKRHGRNGIRAVLLGRGARKGSTTE
>A0A1V5Y3Y7|diguanylate cyclase|EC 2.7.7.65|candidate division BRC1 bacterium ADurb.Bin183|TrEMBL
MKDTKSLIRILELCENIDINAAYIYERFAEQCKGKTKNFWLKMMAEEQRHIEYWRFLLEM
AKEGTLPQIFDNPEDILADLENITKRVKDLIQEAEKLTIPSRMYYISHCMEFYVLHTAFE
RMLRFVNKLSNNKSAAEDYDNHINYFLNHFKECENVPPEMTLLVDAISRLWKENKRLTQM
SEEDPLTGVSNRRGFFRILTPLARLAFREQNQVAVMMLDIDSFKNINDTQGHLAGDEILK
MVSENAKRRIRSSDIIGRYGGDEFIIFFPHIAPKALPKICDEIREAVSKSSPKNLDVTIS
IGVVYGKLVKDPEAEVYEMIRRADKNLYAAKNTGKNLCNIEAIN
>A0A1V5RMX4|diguanylate cyclase|EC 2.7.7.65|Spirochaetes bacterium ADurb.Bin315|TrEMBL
MHEEYRDDILSSVMNTIADPILVVDEEGRYLEVFGGTDRSLYDDGRPLKGKMVSEILTKE
FGQFFVNQVRHTIATGTLNVFDYRLDTQTVNLPIFDGPGGTQWFEARMYPLEQPIEGKRA
VVAMIINISERRALHRRLHELSYKDSLTSLYNRRYFLERVNVHLMEKNQIHLMFCDIDHF
KAINDRYGHLAGDEVIREFAVILQSILGDTVTICRLGGDEFIAALVNSTEEQALELAERV
RRAVEDHCFIYQDAPIRFTVSIGVAPVDDDSLDGATLIGHADKALYAAKEAGRNCVRLYN
NPPKG
>A0A554W403|diguanylate cyclase|EC 2.7.7.65|Tepidimonas alkaliphilus|TrEMBL
MSHPRTLEHLEHVARLTHGRDREGLDATLVEVLASVLHAQTVALWEVVHAADSGPVMRLC
AYAAFQAQARPEAKADRQSSAVAAAAPAADVLAWARGPDCDQARIARLDTGSWRLLVPLQ
TDWGRRLALDIEWARPAGWQDRRVAEGIGRIYINVINLLDASERDTLTGLLNRKSFDDTF
YRATRLPSEPEASLASGERRSPARARWLGVIDVDHFKAVNDRFGHLIGDEVLLLMARLLR
QTFRQDDHLYRFGGEEFVALIRADDAQAAAAAFERFREAVQAYPFPQVGRITVSIGYTAV
RPFDTPSDAFERADRAVYAAKAQGRNTVRCYESDVAPLAREPLHQAGGGVELF
>A0A1E8EUR8|diguanylate cyclase|EC 2.7.7.65|Clostridium acetireducens DSM 10703|TrEMBL
MLKGETIANVIFIYILGFVLNSLSKYVFKLSIQVNYMFKEIKEKNLELKKMASKDYLTNM
YNHRSFYNNLVDTIKKLSDNSTFCVAMFDIDNFKRVNDTYGHLTGDYVLKEVSSIIMESI
SNEDIASRYGGEEFAVLFPGKDLKEAIEICENIRKNIEMHLFEIGCYKIKITISGGVSAI
KASSIDACDHCKFIEKVDKLLYKAKKSGKNCIKWN
>A0A1C4B0A3|diguanylate cyclase|EC 2.7.7.65|Kosakonia oryzendophytica|TrEMBL
MIGENMEQSGHSNHVLLLSEWQALLHQTPPTVHDILTGLGDEEIRHLVNVFYDYMLSHHE
SELFLSTEQVSTRLSHSMFQWLRSVLGSARQDLSQLLEKQREIGIIHARIGLPIDLVARG
ARKLKNELYQVLQAKETIPAALLSEIICFSSLAMDTAIEAMTVSYSPTYQNSMQAQEQYR
LLSIYDDVNVERERQISALTSWENQFIYNIATGLPAADLIPLAKSEFGMWFSHKGKHLLG
NPNMLANMDTLIKQADEHITQALTPALSPVAESRMAVLQAIRQLTGQIHRLLASMFDALV
ELENGKDPLTQLLNRRFIPTIMRREISLALNVRKPFILAMLDIDHFKKINDNYGHSAGDI
TLKTVATVIYDHFRSSDYVFRYGGEEFMVLLVESDLTQAKIILEALRQKIAALSIEVSPT
QHFSVTVSIGFVDFDYHPDYKRLIDKADRALYAAKDHGRNRIEAHPR
>A0A3V4FNX5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Heidelberg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A8F9HNM0|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MLTNFPDEKYISDRNSSFIKRVYFLRQIGVVLCFLPIYSVLQEQSHQKITTALLILNALI
WPSVAYLASMMSKDMLSTEKKNMILDSFWAGIWIAVMQVSPIPSLFIISVQIADRYAAGG
WKILKPALMWMMISFLTVWLVNDFRYTIEFSTRTVLLSLPLATCYPIVLSIVSRHLSIKL
RKRRELLEKQALMDPGLDLPNRRFFEQKMESAFRATRKKRIHSYLMLIDVDNFKKINDTY
GHEVGDAVLSRISTILRECAGEKDVPARFGGDELAIIVNNSNSKLVIAMVHIIQKKIKDL
SLPSHNDIYCTVSIGISCAENKESIIEWIKEADEMLYEVKRNGKNGYCMPNN
>A0A225UAB4|diguanylate cyclase|EC 2.7.7.65|Raoultella ornithinolytica|TrEMBL
MDKPLWVRKLRRVSRPGHVVNYCFVAVLFFSTLLIWREVMVLEGAYVTNQRNNLENVADE
LDSLLLFNIDRMVFFRNGMQSALETPLDFEILRNAEQEYMSKRHEPIWSVALHNRRTLPV
YGVSDDFVDSQSSLSRNDALTGNELMAVLELGYLLRLVENNRGFNERMLYISRSGFFTST
TLPKNAVQAQTLYTHAIAAPWFTRQSQRNNPGRGVFWQTVLDEHAQNDDPVVTASIPLDF
RHDWLGVLSMDFSVREMKAFLVSAIKGGQEGEYQLYDSRLNLIASSASGNVLTLLSAREQ
AMLSYAFLHQNQGGIRLLTRYISWQKLNNFDGVLLRIHTLQEGVRGAFGTITIALTLMWL
LFTLMLIISWLVILRMVRNMSVLQKSLEWQAWHDALTRLLNRGALFERAIATTRMCERTG
RPISVIQLDLDYFKKVNDQHGHQAGDRVLSLVASTIASNIREGDLAGRVGGEEFCVVMPD
TTLQVATAIAERIRIRIYSREILLCNDTSLRISASLGVSSSDDCAGFNFENLQSTADHRL
YLAKQNGRNQVCFNDLPSCAGLRK
>F9DTZ3|diguanylate cyclase|EC 2.7.7.65|Sporosarcina newyorkensis 2681|TrEMBL
MKLETGIYVFPASFSYREIDKRNLIMNRWGNASDGRGGKEMNQKKYQDMLAQRTENIFKD
WEARGSLTERELYYFLHKLKGTSGTIELQQLSLFCASQLEILSSSNDQKIPVSSLENLKN
RIRSHFDGSEAVKKEEFQLPDCYINQLDQETFILIIDDDLEFVSYLKELLEKMGAQVIIS
LNGKRGIEQFYSMRPSIILVDTKLPDMSGFEVLDQIADTARQKNTMVALTSEQATKENEI
ESYRRGAMDFIPKPFDMDIFFPYLFNRQQRQHAISSSIITDSLTGIGNRRYFDEVINNFA
KKADQSDTTFSLVMVDLDHFKQVNDLYGHPAGDDVLRKFGEILHDEKREGDYVFRYGGEE
FALLFVNLQADEAVHVVERIRNKFNPLSFNSGDQSFNVTFSAGSADYQGDTEELISAADQ
ALYEAKRTGRNRTILYDQRKRMVKRKLMVIIVDDDSFIRQILQQTLLELQSPDIEFTVKT
YSDGPAFLEDDWYTPDDYFIVLLDGVMPKMDGLEVLSRLKSDHAKTNVTVSMMTARKSAN
DIKAALWLGADDYIIKPFQPADVLGRIEKLANRLFDKRE
>J2VDI4|diguanylate cyclase|EC 2.7.7.65|Pantoea sp. YR343|TrEMBL
MPNSPQLSRWKSPFIPVHLCFLAVFLFSAFLTVHEAFELKNNYEQRQRAQLSDVQKNLDS
QFQESLDELLYYQQMLNYALTHPLDSDHARETVARFQQLRQQNPWQLQLSSPRSMPINGV
GDSWLTRDPLLSRDDTHIDHELRAALEFSFILQFGDTKQDFHSRFWYISRAGFYISSRPP
QNAQELEESYATMIQRPYFRDQDPHNPLHARLRWTEGYQGLFDEGLMMTVSTPIISEGYW
YGVLSMDFTQSRIHALLASARNSSLQGKMVLLDRSLHEITRLTAPNDQPLTAEQKALLEQ
QILQSPAGVSRLGTQFITWSKLRNVDAYIVNVQSLKQGFSQELGRVALFMVGMWLVFVLL
LVAAHQVIFRLVRRLNDMSAKLVWRANYDGLTRLLNRSAFFEQFDALAARGQQQQTPLAV
IQLDIDHFKKVNDTWGHQAGDQAIIRVASVISHTLRKYDVAGRVGGEEFCIVLPETTLAE
AQAVAERIRVRLEAKTILVNASTTFGITLSAGVSGSEEQGDYEAESLQASADSRLYLAKT
GGRNRVCAAN
>A0A811GAN4|diguanylate cyclase|EC 2.7.7.65|Acinetobacter bouvetii|TrEMBL
MPNSKQPSPKQLMSVIQTQTAIAKLGLDLNAVMTLVAEQAQGITNAKGAVVELAEDGDMV
YRAVSGGASHFLGLRLKMQNSLSGLCIAQNETLYCQDSEDDVRVDREACRRVGLRSMAVV
PLIHCGEPIGVLKIYSERVNAFKPGDLQILSLMSELIAAAMYHATKFGAQELYKLATQDN
LTGLANRALFLDCLRQGVEKAKSENKVLGILMIDMDGLKPINDEFGHRIGDAALKEIAKR
ILSNTRHDDLVARLGGDEFAVILTSIANQELAKSAMNRIAESCGLPFVFENVQLSIGASI
GLAVYPEDAQGLEQLLECADLKMYENKREKKQIQLNDF
>H6RMW8|diguanylate cyclase|EC 2.7.7.65|Blastococcus saxobsidens (strain DD2)|TrEMBL
MQVPEQDVREPARPPVTTRSPWGVAVLALALAVPLGVAVVERGPLSVDVPVLLAVFLTAV
VAEWVNVHIEFRHQSFVNSASELVFVIALLEIGGVWTAVTRAAAVGVVLGIQRFSRAKLV
FNVAVAIIDTAVAVFVLGLLPVGDVTDPWTWVSCLVAVFAANAVAAVMVAGAIVMTQGYS
GRALWTSLLVPVVVVSPVAVLIGLAILLLLHAAPWSWVIIAPLAVALVLLYRRFAAVTRE
GNSLQQVYEFARRVEEVRPDEAGTRQIVQAVRELLNAERVALWLPPYLDEGPRLVVATES
GAHWYDGPGDPDDPLRRRAVLSTDGVIQVCAARADESEVAALARRGVSDVLGAPVTTAAG
EPGYLEVCDRRSDLVTFGTSERGALDSMLTHVNAAIRQQQLLTRIRFDADHDRLTGLPNR
QRLAAEIDQLLSADPADARAGLILASLGTYADVTDTLGHAASDELLLVTAGLLREHAPPR
ALLARMEREQFAVLLPGLSLDETERAARRLREAAATRVRVAGLDLEVSLTIGVVAAPVHG
THAGALMQRADVALLAAGDSGGVASYHPVMDQQSLRRLQLGTELEQAMADGQIGVVFQPV
IDAQSSDIVSVETLVRWTHPRYGAVPPEDVIGLAEQIGRIGALTDHVLDLALARCRRWLD
QGIALSVAVNVSARSLADPDLVDRVRSALERHRVPGELLVLELTESSVVDDQVRESSVLE
HLHDLGLRLSMDDFGTGYSSLSQLRQLPIDEVKIDKSFVLTMATSQGESFIARSIIELAH
NLGLCVVAEGVEDEMTRNQLTAMGCDKLQGFLISRPLPEDRLDKWLLARTGVRSAAPGAI
HRRLFVRT
>A0A7Z8ZD15|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MTNWAYGITVALTLASGIAMLMASNADTAERQAVQQRQIFDQLTEEVETDTWELSDLART
YVINKNPDVLEEYRQQAQATIAIEHRLGKLKDSGATPQELALLREGLRIADELQDEQQAA
LASVARGEEREAIDLLYGKAYERELERVQTQIDHFRLLLDGRASGAIVQATEKSHTWRSL
SELMVGLTALMFLFVLGFILQRRVLYPVVRLSDVVQRLASQDYAVEAPNFTQIDEIGDMA
QAIRIFRENGLARQRLEQERDADWAIRELLARMTQRLQGCESFEDVIKVAELFAPNIAPE
IPGRLYILDLDPWQMRCVASWLSPPDEPELFHPDDCWAVRRGLSHPPVNGEPDIACYHLP
ESSAQWSLCVPLIAQGEAIGLLSFRNVTPATAPSRAYLELMAEALGLALANQRLRSALLE
KALFDSLTGLRNRHHLEDALHTQMNLAVRNGTPLSCLMIDIDHFKAINDRYGHEAGDLVI
KNVATIVQRAVRDIGMAFRYGGEEFLVLLAGTNEESALACAEDIYNNVRDMTLRYGLSEM
GQIDVSIGIASFPQHTQSDSLLRAADAALYRAKELGRSRIVSFGMLKTD
>A0A658P172|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. AAK_AS5|TrEMBL
MDKGHSPIARPTFKRTLRRISIISVLVTMMLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQKVIATWRYNAQDTTEKISGMIS
HWLFPQPVTQPILHNGNVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFALDFNSLLDEMEEWQLKLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLSEFGGSRHYPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIKK
>A0A8E0KIC5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O119:H4 str. 03-3458|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDNSASKEDENYRIFSLLENAEE
EKERQIASLLSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A3P8KRL9|diguanylate cyclase|EC 2.7.7.65|Raoultella terrigena|TrEMBL
MKDESKKYIAVIFKEWLPLHDGLTPEVKAVLNNIAAEQAEALAARFYDFIFQDPDIARHL
TYDLVQERLSRSLAGWVKDILTCEKDGLQALAERQYHIGSIHSRIGIPAEAVLRGARQLK
AGVIEYIRDSAIDRQTGVAAIYYAIMAFNMAIEMMCHAYTLSHYRATKNEEAYRLYSLMD
NVPMEYGKQQAALSGWENTVIFNIVSENKNDINATLLSESEFGLWFRHKCVRYFNKNAQM
EEIGGLIAEVDSLISGWKSADSPYGI
>A0A839WJV0|diguanylate cyclase|EC 2.7.7.65|Atlantibacter sp. RC6|TrEMBL
MNDEQTFNKWRLWDISAREKPLNDDKYRSGLRFARRIWLPRTVGHFCNFIMFAGVLVDQA
LPGWWWLALVMYAFVWPHLALQIAERSSDPMTAERRNLIIDTLMAGIGIAIMGGNALPCL
LLSMMVNMNNIGAFGVRFFAAGLMLQMMTALMSVPFIDAPLNVTTTPLQFFLSLPTLIIY
PALFSFVCYRTAVNLAEHKRRLQQISTRDGMTGVYNRRHWEQLLSIEYENALRYRRASTL
LLIDIDHFKQINDTYGHDVGDKAIIAVTQYLQLTLRVSDVIGRFGGDEFAVIMSGTSPES
AVAAMDRVHERLQNLSIDNAASLNVQISVGIAPFNYHMKDYQEWLKAADMALYKAKKAGR
NRTEVHTVR
>E9XKB5|diguanylate cyclase|EC 2.7.7.65|Escherichia coli TW10509|TrEMBL
MEMYFKRMKDEWTGLVEQADPLIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKVLLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTIRNTKNLSNKTLRVRFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A1Y5TTL7|diguanylate cyclase|EC 2.7.7.65|Roseisalinus antarcticus|TrEMBL
MTLYRFLSRFLPASYLAKLFLVVFVGFAVPLAGLVLYSVGSGANVDRSLLGVLFAASCAG
MVLVLLGLRAMLEPMLMVTGVLDRWGRTGQVQILPEDYKDEVGLLMVRTNRLMARAQRTL
DQSRRESDTDPLTGALNRRGAERLLRDAPAGWILLMDLDQFRFVNDRNGMAEGDRILREV
VQVCANILRQDDLFARFAGEEFLVFLPGAPRHVAGRVAERLRSEITQSVTVRGLMLTASI
GLAAHPGGDSIDAALEIAEAELGRAKDLGCDRICGAEDGGQRAA
>A0A238KMW5|diguanylate cyclase|EC 2.7.7.65|Pelagimonas varians|TrEMBL
MIAPQPETETERLKYLDRLQLVRSPRTPDFDAIVQLASDILDCPIALISIVGREEQWFKA
KHGLDVDATPRDISFCSHAILQDEVFTVEDASLDDRFRDNPLVTEEPNIRFYAGFPVSTD
GVNKLGTLCVIDRKPRVLTDRQQHQLRLLGTAVEGLLRTFESERITIEAARNITQKAKQA
ERTATLLDRIAEVSGVGGWELSLERQELFWTDQTKRIHEVPIDYRPNYASARAFYEPDSA
DMVTAIVDDAVENQTDWDVEARLITATGRKIWVHTVGTPLVEDNKVVGLIGTCRDITDRK
KFELQLQNSEGLAKKKSIELRTILDRMDQAVSVFDSDAKLTTWNQNYIEIFNKPEGEIRE
GVDFEELITAEKLRGDFDGDVTDYLETLYSSLAIGESVAAEIRLKGGRVISSIHSPMPDG
GWVGTHTDISERVKVQEKIKHASLHDALTKLPNRMKLEDDFGQWVTQNQSKGHEIALAML
DLNKFKAVNDTFGHHVGDKLLQQVAERLQDSVRSGDLVARLGGDEFAILLQCPAENALVV
LHRLADVVVTMLTKPFYIENQSLEIGCSMGISLSNGQNNSYELQMQQSDAAMYKVKRSGQ
SGYGFYRPN
>A0A2H6G186|diguanylate cyclase|EC 2.7.7.65|bacterium BMS3Abin11|TrEMBL
MEEKNTDLQLDDLVRVDNLQLLYHQSYPAIFASLISAALLSAVLWPVQQKEVLISWFIIL
TYTAIVRLILFMLYNRVKPQGEDILSWEMPYFVTQLLSSTSWGIGAVYIMPIDSQLHQVV
IYYFLMGLSGGAIFAYSANRTMTLVTIASLLLPITGWFLVQGGLLAMGLVMGAVVFYIYT
IRAGKILSLTLNKSFMLAHELNNAKEAAETLALKDELSGLNNRRAFYEKGKMLVDYCQRN
NEVFSVITIDIDHFKKINDKFGHAAGDATIIQVGSILLQVIPKSGLCARIGGEEFGILLK
ASASDAAVQLAEKLRQKIAATPIAFNGEDITISASFGVADGNLDLDTLLKRADAALYKAK
ETGRNRVICDECDTEEMQSRLNAKRLLSLIG
>Q2KZ93|diguanylate cyclase|EC 2.7.7.65|Bordetella avium (strain 197N)|TrEMBL
MKLDIFVQRWKDTCAPYSPEIHALALDRINAYAPMLADSFYQGMLADESAAFFLSSQLVR
DRLHASLQAWLRSAFGAAVNQDFENVVAFQQRVGEVHARINIPVHLVLQGTRRLTRSLRE
LVTRDSDVSSELSWPLSNYFSEVMLFAIELMSLAYAASHDRNSRAEEGYRLLSLSQNIGT
EKERQRAALLDWENQLLFDLSTGQDSGKLPRLRKSEFGLWFTHKAAHAFEGAKEAEAARS
QIETVDRLLSETPVTEGRMQLLHAVRDATKTLAYLMDALFERASHLESGRDTLTHLLNRK
YLHVVMSKEVAYARKTSSPLAVLMVDVDHFKRVNDEHGHDAGDLVLQQVGGMIATYSRGG
DYTFRLGGEEFLVVLVDATATQALNIAENLRQRIAEKPLTLPDGLHRRISVSIGVAAHDS
HPDYQRLLKRADIALYAAKTRGRNTCVLAD
>A0A654BXM3|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. 9AZ|TrEMBL
MPSQAESAVANHHVAAVDRLATGFALRLFEPELEAEYRDFSYRSYRQTRRVAICLLLASF
LAFFAFDLLLLYSVGANPITLPVMLVRLCALLIIVFAAYRVLKSPDVATGYRWIPIGLGC
LSLGMLLVTLIYHQGLEQMQLPYGLEGMMLIQIVIFVPIGYSYRNSLYLGIATLLCTGLA
LQLTSSGESPIQYLTSLAYLTLATIAAATAGYCQEHSMRVLFLTKRDLRTMADTDGLTQL
YNRRSFDLLLQRALQEALREQTRIALIMLDLDHFKAYNDCYGHPSGDLALQRIAGVLASH
PRRDLDFAARLGGEEFALVLRNPDSAYLASTCESIRRKISDELAIEHLKNPAQVMTASLG
ASFSNASDTTASLYQRADLALYRAKASGRNRVEID
>A0A0E1M0I3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 1303|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPIIQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMNNSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEIAKRLAEFGGLRHKAYRLGGDEFAMVLYDVQSESEVQQICSALTQIFNLPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A5C6ET10|diguanylate cyclase|EC 2.7.7.65|Candidatus Brocadiaceae bacterium B188|TrEMBL
MFQKRSVRNKFILFTSLLTILPVGILAGFKTNFSRQRLSTIEQTNTNPMNTATKNEWEEK
AHSQVRLSAREITRPTNELDYSETNYLPNLNMEGKGFRYVSARNDKGQALGDSSEGFGLQ
RNISTGEPAQYAPGSEELTRQRQNDAVDVVAPILDGSKVPGVVTIGFSLNETKTTPDALH
NGKTNNLIKQSATIFKQHTILFLPAITIPVIVIGWIFIRGLSLPIQRLVMEMEKIAKGGF
RRRVEINSEDGAGKIGQSFNEMTTDLQRVIISKEYANAIIKSMDVSIVLTSPDFTIQMVN
RATCELLGYLEKDLIGKSLAVLFSDEDVFIMSLLDLIKNNLVHKIEKTFLSKDGRKIPVL
FSGTEIRQNNDDLLGIVCVAHDITERKQIEAELKRAVAQRDMNIKDLGYLMYFSTLMNEE
VREEILIHHMANALQVHFQPELLAVLTIDKTKNVFDAALITPPMPLNKLIRDEVIVDPSL
CQVIRTGREIIIDNNAKDILCECTIYKIEEGGFACLPLITGGTISGMVVIGKKDKEYWYN
EDVRKLILVYVGLTASALQRVRLIDLTRRAAITDSLTGAYNRRFFDEMLKKQIALAKRRS
ESLGLVIADLDHFKNINDTYGHMTGDRALQQIASMMKNSIRSSDVLARYGGEEFIIIMPS
IDITNTLKKAESLRQQVESFQFQIDPVGRSPQITISIGVASFPDHGIDYDSLISAADLAL
YKAKKNGRNRVETV
>A0A1A8XP90|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MSPPGSALSGDVSDQVSALIDTLHTSARRFEEPTAGEVDTLADADRRTFLLRPGHDHMRR
TKAAIVNALPVPVALLDANGLVVMVNEAWRQSAGTPAIQGPGCRTGVNYLDLCDLTADDE
ATETQRSEAGISSVLCGNAKSSSMEYPCHSPTQQRWFMMTVTPLANEHPRGVVVMHGNII
GVLGIARDLTERKSAENRIAYLNRVHAMLSGINTLIVRVRERDELFRETCRIACDAGGFR
TSWIGLVDRRTMNIALVASAGNDEELLAATRNRRSALGGTTSALVARAISEKEAVVANDS
ARDPMLIFGAQGADTGIRSLAVLPLMVADEAVGVLVLYAGERHFFHAEELKLVTELARDV
AFAIDNLDKQKRLDYLAYYDPLTGLANRSLFLERVAQYICSAAGRGRQLAIALIDLERFK
NLNDSLGQPAGDALLRQVAAGLTRTTGDAKLLARVDADHFALVLPEVNPGGSIAHLIEKV
MAAFVEHPFRLDDAIFRIAFKSGVALFPDDGADADALFMNAETALKTAKTAGDRYRFFTP
HMTAAAASQLTMEIQLRQALDKDEFVLHYQPKISLASGKLTGAEALIRWNDPRMGLVPPG
RFISILEKTGLIYEVGRWALRQAVEDYRRWRSAGLAAVRIAVNVSPLQLRNRGFIAE
>A0A1A8XWB3|diguanylate cyclase|EC 2.7.7.65|Candidatus Accumulibacter aalborgensis|TrEMBL
MPTEICDRAIVAPAASGADAAENISEVRSQESLLKTGALQNAIFNSANFSSIATDANGVI
QIFNVGAERMLGYAAAEVMNKITPADISDPHELVARASALSIELETPIAPGFEALVFKAS
RGIEDIYELTYIRKDGSRFPAVVSVTALRDAQGSIIGYLLIGTDNTARKQAEEALLKAGA
LQNAIFNSANFSSIATDATGVIQIFNVGAERMLGYAATDVINKITPADISDPQELIARAH
ALSAELETPIAPGFEALVFKASRGIEDIYELTYIRKDGSRFPAVVSVTALRDAPGGIIGY
LLIGTDNTARRQSEAEQKELGQRLRDHQFYTRSLFESNIDALMTTDPSGIITDVNKQMEA
LTSCSRDELIGAPFKNHFTDPERAEASIKLVLSKKKVTNYELTARARDGRETPVSYNATT
FHDRDRRLQGVFVAARDITERKKAESQILNLALYDSLTGLPNRRLLNDRLVQTMAASKRS
GHYGALMFMDLDNFKPLNDTQGHHVGDLLLIEVAQRISRGVRAVDVVARFGGDEFVVILN
ELDEDKIKATAHAAQVAEKLRALLDKPYVLKFKQEGKTETTVAHHCSTSIGVIVFRNHEE
TQDDLLKWADTAMYQAKEAGRNLIRFYQAKT
>A0A4U6HBX2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls714|TrEMBL
MDKGHSPITRPTFKRTLRRISIISVLVTMTLIWLLLSISSVLALRQYAQKNLDLTAATMT
RTLEAALVFSDSVAATETLAALGQQGQFSVAEVRNKNQNVIATWRYDAQDTTEKISGLIS
HWLFPQPVTQPILHNGSVIGEVRLTARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVEALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAARSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGDRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQAFNRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADQNMYQAKHLRSERIIK
>A0A174CU39|diguanylate cyclase|EC 2.7.7.65|Coprococcus eutactus|TrEMBL
MNSRKNHNKKLMLPVLIFLVGCLVLTVVLYHSYRSNYKQVRNVTALNATTYAERLQNDMN
RGVAITDTLEEIAISENGKIDNFQKVARDLMADFIQSIQIAPDGVVTDIYPEAGNEAGKI
DLMHDESRGEICRYGRDKNIVTMQGPFDLKQGGQGIAIRNPVYLEGADGSPVFWGFTIVI
IRVPEIFTESIQALTKFGYDYSLTKTVSPLSDDTEIVSSSGNIMKNPITFEFEFCGSLFD
FEIMPADGWSHGWNVFPQLFLGICVILLLTGLTVVILVIERHRDTLKKMAITDPLTGLLN
RKGFDEQLKKVMQGDLHIHCVGIQMDIDDFKFINDMYGHVVGDAALKSLAQDMQSYFNDN
SIICRNGGDEFSAILVDTTEEEARKKIEQFTLQPRHITYNGGEHPFYISLGYAEYPKDCE
DVSELIRCADMALYAVKLHGKNNCSPYRGAYKMQHRSQLGFALQDVSKNLPGAFLIYIAD
PENDNILFANRELIEFAGCRDFDDFLDYTDHRFRNLVHPDERDSVETSIWKQIDAKTSGN
NDYVRFHFAKKDGTYLPVLDHGRIVENRYYGNVFYVLIMDCALVESYYDNKTGLETVPE
>A0A8G2HYQ4|diguanylate cyclase|EC 2.7.7.65|Staphylococcus aureus|TrEMBL
MFEAFIYNISVIVAGIYLFHRLQYSENKRMVFSKAYVTVLMTIVSLLLSVYPIPYREDYL
IHLTFVPLLFLGRFTNMVYTLSATVIVAIVEIVVFNNSIMYGVTLIVIAAVTSAIGPFLK
QNDVLSLLILNVVTIIILFGVALVSPIYTLSEVIILIPISLIITLASAITFVDIWHFFSL
VNRYENEDKYDYLTGLGNVKEFDRHLNEISRKAEKEHQSIALLLIDIDGFKDVNDTYSHK
SGDAVLKQMSQLLKNYVPNQFKIFRNGGEEFSVVIHNYSLDQSVKLAENIRSGVEKSSFH
LPNKEVIKLSVSIGVGYLTDNDPKSQRKVFKDADDMVHVAKNQGRNKVMFNPIINL
>A0A1V5PMU2|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin354|TrEMBL
MLKNVWSGNKQDKISKLPLENIYRNSCGCKKDIDTSQFQKLYLEKELYVAALNFSPYFGL
EFENVDTFEELVRAVHLRLAYKAYGSPGDFGTIFFCMCDESEYNKEDAVEKHLNCTEYMY
LKAIISGDTVSPHDIRFKRSELIPEEYRRRSSSLFIFDLHSKDDCYGYIAIQNDNIEKVK
NIIKPLVFSINNALERIKMYSENQAINQIRAQSYNDPLTGIPNRLGMERYTTRLMERLRY
SDEKYCLMSIDMDGLKYINDTFGHLEGDRALTAAANLLNDAKPDGGIICRTGGDEFVAIF
ISSAEKDATDFIARVEDAIKAANSTGEYPYELSVSIGYEFCNKDSDMLMSLHIADNKMYE
SKKKKKKNRKD
>A0A1V6DKZ0|diguanylate cyclase|EC 2.7.7.65|Candidatus Cloacimonetes bacterium ADurb.Bin117|TrEMBL
MTDGTDAKTPIPVSWRRKKGLREMLALLLDSSGPQREYLINIILAQGSGRPGREPSQRET
RFRCANIIEQLVGLLRSEAVQSKSQLLPFFKYLDSFPLDPLQETQTALSLIFPGGPSEED
KKLFYRLELFWLLTLMGDLDSAGPLRKELEPQISLEKPRLYIIWLLSLARILQKRGKRIS
FSTLWLNIICEYYRLDGAATALYLILRWVRMINWGRDTALRKKVLHRFGARLRQRKDLLS
ATLLYELFDQEHRHANPSEKMLYTKLLFRHSSSLLSVQQLQYLHFFAGNYLSAVKSSFPQ
SIREFQHSNYYLHKSWSHLRNLSLFLRANLRDDQYAQSMSYLQQRVVDLSSQISLQNNAY
VETLHENYSTIKKLLRQVEELSITDNLTGLKNRRYLTNNLYHAFQLAARHKVPVCLAILD
IDYFKSVNDQLGHLAGDQVLKSLARLLQSSFRKSDAVIRYGGEEFLLVLFDVDPERMSEM
MEELRRKVKNQRFSWQGNPIRISVSIGWASCPACLKQSELEKHIARIDAALYTAKSTGRD
LVVRATD
>A0A5E4UX73|diguanylate cyclase|EC 2.7.7.65|Pandoraea iniqua|TrEMBL
MVKTLKGRVAATTALVSMILIVGVAVGIEFFVYGELRSSLQAQLDNQVKLVADQLDDKVR
AKYLALHRISRHLGNPYAMTPAQLDAFANASVSMPETFNTLFVAAPDGRVIYDSTFPATP
INVADRDYFKALLGGAPQAISGLIAGKITRSPGVVLAVPVRDADGRLTAVVGGAVNLLRQ
NFIVDLASNAVGDTGRYCLITNETPARYVIQADVTKILTAVGPEQTLCGVRDAGSHDLVH
MHPLVARASMSTAGWSLVAVLPGAEAFDPLARVRRRVVMLAIAAIAIAAFVMWWVARRML
RPIDTLRDLVTRSASDLRAIQSLPVQRADEIGALANAFRDMMERLGDRTEALESSREAAR
ANVRRMQEIADRVPFLVAFLDGEERFAFVNRACEVRLRRSREQILGSTAQDLLGALLYRE
FAPYLARAYAGEAATFVWDFGENNEYRCFEVSYQPEWAANNALVGVHVFVRDITIERSNE
RRWRRESHTDHLTGLLNRKGFDQALAAAVRRAREGAGAQALLFVDLDRFKLVNDTWGHAL
GDELLRRLAKRLVACVRESDDIARFGGDEFALIMRDIHDVKDVERAAKAILEVASRPMAL
SVGDVGVGACIGVAMVACGENKTADMLFQDADRALYDAKHGGRGRFVFSVGASARSL
>A0A5I5DZZ8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Miami|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNTAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>V0SBU6|diguanylate cyclase|EC 2.7.7.65|Escherichia coli 907672|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVALLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A0A3W8U1|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. HR7|TrEMBL
MDNECMDMLAEQWQQICQNYSSDDLLHAFQFIQDNAPVLVEEFYKQMLLEKESAEFFSDD
LIQQRLRNTLHQWLIESFSVGINKHFLQAVQKQHTVGHVHARVGIPGWLIMRGIREINRK
IFELLAENSHLLTLSACSYLMQITSLATEIMCRSYEARTAKNQEIKHSYRLFSAMQDVAV
QKDKQRGSLLDWENELMFKVFSGQENFRHPMLSKSEFGLWFIHKASYAFTGSEQAQLIID
RIYEVDKLNQVLAESSNKEQKLELIQHIRELNREVQHLIDQLFQVAEYIENGNDSLTQLL
NRRYLNTIVSREITYARQNRTPLALLALDADFFKTINDKFGHAAGDLALKFISENIQKYS
RGSDYAFRVGGEEFLLLLVDTDQQRALGIAENIRKCIESGLLTTAQGIQFKCTVSIGCAI
YDGHPDYQKFMDSADAALYAAKNTGRNRVYLLKNGPDTSTKSAGVPMA
>A0A8B6I527|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MDMYMRLLIILICFLSYYLYHYNFFKYLDIMISNSKNKYKVYIIYSLFNYLIFIICTYLR
LHLIINWTIFTLILFIEIKITYKTSIIKNLFYSLNCSIIGLAINIFFRSLMSITLDMPAY
LFDSNYITNIYRVYSISSSFIVTGLYFCYKNHKNNQINFDTVLEDKKNLNFLLSLMFVMY
LYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAEKYSFRITQIKSYDIKNQLEYLE
SIKTEHEINKLNDIVYTDLLTGFYNRPFVNQKLSEWMSNHYKFTLCFTDLNRLKLVNDNF
GHQFGDKYISTTAKIIKKLINVENSLLFRYGGDEFLFLLQDTSCIEAEKIMIDINYELSK
LSNTDEYPYALSISYGLVEWDGISDIETLIAEADSLMYENKLKNKSTLN
>A0A450CQQ6|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MNIYMSLLVILLCFLSYYLYHYNFFKYLDIMINNSKNKYKVYIVYSLFNYLIFIICTYLR
LHLVVNWTIFMLILFMQIKVTYKLSTIKNLFYSLNCSIIGLAINIFFRSLMSIVLNMPAY
LFDSNSITNIYRVFSILLSFIVTGLYFSYKNHKNNKINFEAVLEDKKNLIFLLSLMFGMY
LYLCLSLSIYYTVGNVLILKLYGIKSAIIVLVGNYIAERYSFRITQIKGYDIKNQIEYVE
SIKTEYEINKLNDIVYTDLLTGFYNRPFVNQKLSEWTSNHYKFTLCFTDLNSLKPVNDKF
GHQFGDKYISTTAQIIKKLINVENSLLFRYGGDEFLFLLQNTSCIEAEKIMIDINYELSK
LSNTDEYPYALSISYGLVEWDGISDIETLIAEADSLMYENKLKNKSTLN
>A0A2T2XXB6|diguanylate cyclase|EC 2.7.7.65|Kluyvera genomosp. 2|TrEMBL
MEHHELSAAQRSGRGQWNAHQEVDVRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVL
LTSTLLTWRETIVLEEAYISSQRNNLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLA
FEVLRTAELEFEHKRGLPDWHISLNNNRTLPLYGVSDDFVEHTNLLSRDNELLGNEFMAT
IELGYLLRLSALTHQHLSRFETEMLYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQ
SQRDNPNRGVKWRTSFSHDKVPVAQKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSV
EGEDEGEYQLYDRRMNLIASSEQDPAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISW
EKLRNFDGVLLRIHSLEEGIRGDFGSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQ
DSLEWRAWHDMLTRLYNRAALFERAGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQA
GDRVLSHIGRIILNKVRKTDIAGRVGGEEFCIVLPETSLEQASVIAERIRESIYRREILI
SRNQTLRVSASLGVCSSEELQRYDFEHLQSIADSRLYQAKQNGRNQVCTED
>A0A5J4E5X4|diguanylate cyclase|EC 2.7.7.65|bacterium MnTg03|TrEMBL
MSEAENKPVILLITQSSRSANMIEKLLRGYFTSLKAGDAESGWNLLVKLPVAVIACDLGL
AIDNFGLLERIRNAKDRSLATKPVLLLIGEQDQGKKRENALGLGATDFINMPFSSSELIT
RTQMHAGLIGHHSVDPTLEMEHIPSVNGLKQLTDEKYFNSRLQHELSFSLRHKNVVSIGK
LRVNGLKQLVAKFDKNAAIGILHTVARIIQENMREEDVLAYLGDADFCLLYPATNGIEAF
AAANRILKNIEKHDNKINGKTVPIAISGAISSSVASEDTTVEKLMGILDELLVRALSEGD
NKIVSVLQPDEKEYMTIERALKYIEHGAADGIKDHLGELVLSILPLLEHADLVLGLELES
VNQSLKERLGKSKPVNTGHDAGVRETREKIG
>A0A0S3PXB2|diguanylate cyclase|EC 2.7.7.65|Variibacter gotjawalensis|TrEMBL
MLDLPTLFLAAGLSTFLLAGLLFAAWRQAPEHRALAWWGGSYLVLLIAIPLLAMRSLLPP
IFPFGLSNGLFIVAGACAWIAARRFEGRSYEAWWAFTPLAIWLALYLVPAIGMNPPIRMA
IVSIGIGGFLLAGAYEFWRGRREPLISRWPAIITMAALGIMLFVRVPFLIFVEFGANKPP
SDLQGSLTIVAMLGFVYIVIMACNILAMTKERSELAYRHQARTDALTQLLNRGAFLDEAE
AGVEQANAAAMPISIVLVDLDRFKQVNDRFGHLVGDLVLQALAQTATAELPARSLVGRVG
GEEFAVLLHQPADQAAGYAERLRQTFDANARIVDGQAVEATLSAGVSTMHGNAKLLTLMA
DADRALYAAKESGRNIVRVAQVEIHADQGENAHSAAA
>A0A7Y0LSI5|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MEEIDDTILDSMFKLTLNERLLNNNDFIENKIDVVKNLIDCYKTEQNSLMLLKSNFLLAL
LYGIQGVSEKMKEYILISCKYIDKCLPKDYKFLARFYSQIAILSLKNEDINKANLYIDKF
NLICDENNFLIEEIIFKSQLIYIKASKCIESSVIIKEIEALYIKIKKINDFNCKKMYFFI
IGKIYFLFLDDALIAKVNFLKARKYADLLKDMQVSSLCNIKIGECECSFENYECSMEYFN
EVISNKKYRNVNIIQKYRASNNITKILIKTRNYPMAINNLAKSEVYLEKIKNQNLKEVAK
FDLFISLAMYYAKSNEKSFEQSICYLDRAKNILNIMKNIEEYTMYDLEIIYHQAKIYYIF
GYYENALNTNKKLLEKSKNAKNYNYVKLAYKNIYLCFEKIQDYEISMKYFKMYYELKMMY
IKARNRNYIDSLNYRHEYIEKEINNMRKVKLDLDKKKYIDHLTSAYNRTFLNDFLEKQEV
SEYCTAFMIDVDYFKEYNDTYGHYNGDIALKNITMIIKKYLKKDMLMIRYGGEEFLILSI
CKDYKKSKIFGRKLCRTVKKFLNNNLTVSIGIDTCKNSSIDIREIIKNADKALYKAKESG
RNRCLHYNDFKNF
>A0A1N5VBS7|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. bolletii|TrEMBL
MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYALIFAAICIAVQ
FSDTGPRSMIGRVIVGLCAVGSLGWALRWVVGPWPSLREAVAFVAFADIGIAVACWQDSD
PLAGLVGTVLFTPVGAYVSFFLANRLLVAHVAWCAPMIVALSSRLFAEGTVGAAMTALVK
VTSMLLVVVLIPAVIQFGIAVVRLDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPL
DGDQVTAAAIVDIDRFKSINDRYGHGTGDRVLVDVAHALTCGTTGTSVVGRSGGEEFLVV
TVCPAAAVAEFAARLREAVTASMPAGIAVTASVGVAAQAVSRVVSATSQEAIEVLTACAD
RAMYEAKRDGGDQSRILHADHDSEGRYL
>A0A1N5REU5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides abscessus subsp. bolletii|TrEMBL
MQNPPYVETGYQYDLVTNALRDTGQLGRLKTGIGLLCFVIVFLQGVTQFYPLGPHGTWPR
VVHGITAASAVVAGLCWLSFSWPGRRAMAAFVVWADVALAVGAALLSDPTARICAIVYLG
PVGLLPTFFLSRRALVAHCAFATSLLGAVLAVNVLSGEARMFEQFFYAAPVISAIVLVPA
VIQLVLEGGRDSILSAALAADRDPLTGLLNRRGVTSAMDLLHRGRLDAIDIVVVLMDVDG
LKELNDTHGHGAGDMTLKAVADMLRARTRVGEIAARFGGDEFLVVAFPGRGEDIESTIRR
VSAPRAGIDYWTVSVGAAWQSRTGSKVDLESLVQQADHSLYEAKKTRGMLDPQR
>A0A1Y6J091|diguanylate cyclase|EC 2.7.7.65|Vibrio mangrovi|TrEMBL
MPEKNDNNRLLISPGSTFASQLPGRLTLLVLLTIIGMSWYLGNYNVRQERKEALKHLKAS
VWLLKETLDTLPSGLPVHTLPSPERVRIQLIMERMRNNLESPLYLIDKTGQLILTDGEGG
PLKTKKGQQLQYLPELKPAIEHLLAGQDHATYSAPDGTHQLIALPLNSSPALVVGDIVMP
GWFQSSGFPIYVLLCGGMLLTLLVRYFTRKTVREWRRQSLAQSIIDPLTTLPNRKGFALL
SKPIFRESVDHQTSLSLMLINLNDFTHINLTYGTEAGDILIKQVASSLRQLVNTPHLLCR
WDGDEFIIMLKEHDSSAAYSVAKSIQEFISRHEFNFSGESVRLKLRIGIHSLGDREDLHS
LLSGATHALAQTRKNSDNCILYQKAASI
>A0A1E3H297|diguanylate cyclase|EC 2.7.7.65|Methylobrevis pamukkalensis|TrEMBL
MIDVDRFKSINDRYGHETGDAVLCEVADAIRGTLRGRDIVARLGGEEFGVYLCDIAPGDV
DQVAERIRLAIAERKIRVGNRQIAVTASLGVAVAGPDGLTFDDLMRGADGALYAAKSSGR
NRVCFAGRLQPA
>A0A8B4U1I8|diguanylate cyclase|EC 2.7.7.65|Klebsiella quasivariicola|TrEMBL
MPECQHPANRPISAALPRGTLLPALLVIVAVAVGCALVSPPIGTLGEILANPGLYIDLLA
LLFLVFMLWSSARVRMSHIAVNWVRYGLLLWIAGGTFDVMDEIVVQPRWMGYYCEDLLRL
SGMLFTVVGVYKIIERINLLYVDARSQSLKDELTQLPNRRFFIDTIREKSGQGLGLMILD
IDFFKKINDTWGHLVGDEVLFSLGKQLAKLTGEHVQPARIGGEEFAIIVDGQSEPELHAL
AQDILNNARTILINNQTPLSISIGVGTWRPGEAQETFIRKVDEALYKAKHNGRGRVEWA
>A0A3S4IBV5|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MGINRKDIDKLFTGRTVISSIYMDDITQENVMSFLTPVYLAGTLKGIVMVDVNQDNLKNI
FYTQDRPLVWRYLNVTLKDLDSGKEIIINQSKNNLFQYVNYNHDIPGGLRVSLSLDLTYF
LVSSWKALAFYLLATALLLNMVRMHFRLYRNVTRENISDAMTGLYNRKILTPVLEQRLQR
LVNAGTPVTFVAIDCDKLKLINDTQGHQEGDRIITLLAKAIKTSIRKSDYAIRLGGDEFC
IILVDYAADLAIHLPERIIRNLQIIAPDKTVHFSAGIYNMQPNDTINDAYQASDAQLYLN
KQQKQHRS
>A0A1V6AFW7|diguanylate cyclase|EC 2.7.7.65|Firmicutes bacterium ADurb.Bin146|TrEMBL
MKHYSKAFTTVLAIAIVFVLWIAIAYNHSNISIKSAPLNPFPQMQLIKGEDETVYRAQTI
LTKDFDKPMALLFKTSHMRLKIYINDEMIYSFGYDENAIPFLKSPGTSYHLVKIPALSAS
KQLTINFQTPYSNYSGYIPYIQYGTEGECIADYQGNAIYALLSIMIILIGGFTTIVLYFI
TRHKKNSMSKSFLYISSFAFLVSIWLLFQSDSAQLLFGYPQVMYYIDLISLILFPIPLNI
YIYSLSKNEKRKPITYLCYAYLVVLVLNIMLQLSGLVDMFQLVLLTHSLMAVNILFVIYL
LYIELHIEKNQDLKKFVIPLIFIIIGGAIEMILYYSSHMTKTSIALRFAVVAFLIMIISN
AIRSYYNSVLDLKQAEYYEKLANTDMLTDIGNRNKYEQVLSSHKQEEPLTAVLFDLNSLK
YINDNYGHVIGDSVIKKCSECIKESFSSKGECFRIGGDEFAVLAKTNDSLEKECNTFDRL
VNGWNNKLEFTFSVAYGVARFNTVVDKSAYDTVKRADFAMYHMKEEQKRKMMR
>A0A379SLY1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. arizonae|TrEMBL
MVRCWEDIYRADRSRSDMEQEMVLHCRNGGSYDIHYSITPLSTLDGDNIGSVLVIQDVTE
SRKMLRQLSYSATHDALTHLANRASFEKRLQQRLQTIQESPQHHALVFIDLDRFKAVNDS
AGHAAGDALLRELASLMLSMLRSGDLLARLGGDEFGLLLPDCNSDSACFTVTRLINAIND
YHLCGKGACIGSAPAPGSR
>A0A8F8RR84|diguanylate cyclase|EC 2.7.7.65|Streptomyces anulatus|TrEMBL
MGGDDARLRAVVSLAQTMAAAYTPRESWRAAALGACEALSGSFAALSVWERDRGRLRVLV
NAGQRAEGEEEFPEEEAYPVHEFPEITEFLHERWAGGGEPDAWVETADGQPGAGGPARGA
RPYCHQRVAALRRRGRSCCVVAPIVLHGRAWGELYVARPAGQPVFDRADANFATVLAAVV
ASGIAQNERLEEVRKLAFTDPLTGLANRRAVDIRLDEAVERHRVDDTVVSLVVCDLNGLK
AVNDTHGHAVGDRLLERFGSVLSLCGAMLPEALAARLGGDEFCLLAAGPPADAVVGVATE
LCDRAAVIELGDGVACGVASTGDPIGPVRSARRLFRLADAAQYRAKAARSPGPVVAGRDG
EVIRLADSPPKSAHDRRRLRGNRP
>A0A7L6DWC8|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-00903|TrEMBL
MNDENFYQKKVVPNEAFLSLHQNDHQRSGLRFARRIRLPRAVGLGGMFFPIASVLVAQPI
TGGWWLLLVGWAFVWPHLAWQLASKADDPLHSEFTNLKADAILAGMWIGIMGVNLLPSTA
LLMIICINLMGAGGMRIFIAGAVLMMVSCLVTLQLTDISVAFSSTQLSVLLTLPVLVIYP
LLFAWVSYQTVIKLAEHKRRLQVMSTRDGMTGVYNRRHWELLLRNEFDNCRRYQRDATLL
IIDIDHFKSINDTWGHDVGDQAIVALTRQLQMTLRGSDVIGRFGGDEFAVIMCGTPATSA
IAAMSRVHERLGQLRLSCAPQVALRISVGVAPLTAETEHYREWLKSADMALYKAKNSGRN
RTEAAA
>A0A5Y2LS51|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSVQPYIADEQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A5Y3XAH1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. salamae|TrEMBL
MPHETLLENQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVVSQRNHL
GSVANALDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRRFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLENELTATLELGYLARLARSSAILTLETMYVSRS
GFYLSTLPTASGSDIVSRYYQYVTQPWFIEQSQRRNPQRGVRWFTSAQPYVADDQKKVTV
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLADSTPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGVLLRVHTFREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYRESRQPFSVVQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRSHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDAAQEREKK
>A0A127MYU5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas citronellolis|TrEMBL
MTLRNRLLLLFLPLLALILLGIWQLSEHILLARFDRDDRQRLYDEVRVLDNRLAFEKKRH
LDLLRSYAWWDASYRFVAHPTPGFVRENLDIDMLGNLGFDFALYLDRQGRVVAQRWEEAR
LTAPQAITGAPSPERLRQALLRSALDLGVLDLQGDPSRSLAQWLLVDGTPLLLLSQPISD
NLGQAEPVGAIVAGYLLDQRRVNALQEQMDARLQVQAGVTPGDGWRALHVPGRNGGALLS
PRRVLDADTQQATLLFLDSADAPQFSLAINKSRVAYRQGQEAIRLFLGMTLLITLAGLLL
AYLVLEFWVIRRVQRLNRGVANIGADTAGPARLADMGRDEVGQLACEVNQMLERLERSEA
RDRAILDSIRDGYFEMDDSGVVLTVNAAFCRLLGYAAEEVEGHSYRELLDEQDVARARGL
YQQVRDGEQETTFAAPFKRRDGQRMVFETKVSPIVDAQGQFCGFRGILRDISLQVAYQQR
LLDLAYRDALTGLGNRKAFGEQLPLALQRCAEGTGLALLYIDLDHFKPVNDRYGHAAGDA
VLVAVGERLRGNLRQPDMAFRLGGDEFAVILEGVDCSTAEALAGRLLASLNQDYHAGEQR
LEFLSASIGIALYPADAGDTDGLLQAADSAMYRAKQQRNHYSRYRA
>A0A4V6CDS0|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. wls619|TrEMBL
MNKGPSPIKRPTFKRTLRRISIVSVLVTMTLIWLLLSISSVLALKQYAQKNLDLTAATMT
RTLEAALVFSDSVAASETLAALGQQGQFSVAEVRNQKQKVIATWRYDAQDTTDKISSIIS
HWLFPQPVTQPILHNGDVIGEVRLIARDSVISHFIYLSLAVLTGCILLASGIALMLTRYL
HNGVVDALQNITEVVHDVRTNRNFSRRVSEERIEEFHLFAQDFNSLLDEMEEWQLRLQAK
NAQLLRTALHDPLTGLANRAAFRSSINALMNDDAAHSSSALLFLDGDNFKFINDTWGHAA
GDRVLIEVAKRLAEFGGNRHHPYRLGGDEFAMVLYSVHSEYEVQRICAALSQEFTRPFDL
HNGHLASMTLSIGFALTWEHASAEKLQELADHNMYQAKNLRSQRIIKK
>A0A2N7R4A0|diguanylate cyclase|EC 2.7.7.65|Janthinobacterium sp. AD80|TrEMBL
MISITRPLQRLASHVYRISLVPVFALLLLLVMWGAVIYQLGQEQVSAARDAVAGSQSLAR
TLADHTSYILRQTDHATQLFKLKYEESGGGLRLNEFTRRQGLLDSVLPSKLELPIALVDA
HGNVVDSANAYFPENLAHQAFFRALAANPADTPLVDTPMLDADSKHWTIRLARRLNDGQG
NFAGAIIILVDPTYFVDDYDRLNLDEHGALMLVARDSGLTVGRLGEQLIISDRIDFRMPG
PPHHAPEELVIEPPVDAVPRIYSYRELPRYPLLAVVGVSRTVALARFEHRRKVYLGALIA
ASVLIAGFTALLARQSARLRCSIRQAKETQALLRAAHQGSLDSVLLLKAWRPAPGKPVED
FIFADVNERAADMLGKPRAELLGQRVLPHMPLLRGERFFQRFVQVLETGQPLEDEFELPV
ASGGTRWLRHQVVPISDGVAVTSRDISARKHDELALQDNRSFLQSLIDHLPVLVYVKSAR
PENFGQMEVWNKAAEDITGYLAADIIGKTDGQAFAPDFGLHDAEDDRAILAERGVIDHTD
KPLRLLDGSLRYLHAVSVPVFDEHQQIEHILCIAEDISQRRQQELELRQKQAELAAVNDA
SPLGLVRLDRQRRCTYVNRTFEAITGLPRAAALGAGWTSALHPDDYPLMHVALEQLTRSH
APFQSTLRCLHRDGKLVWVSVKIAPILIDGQVEGYVGSLDDITTLRESEVALLESEARLR
TIADTLPAMIAYIDADQVYRFLNIAYEREFGLTGRHVLGNSVRATVGEARYRTVAPYIER
VLMGETLSFEEEDEKEGIERCMEVIYIPQIGEDNLQVVGFHVMRQDITVQKREKQRLLKL
AQVDALTGLSNRAGFQQKLSDAMHASRQQQHLMAVMYMDIDRFKPVNDTHGHGIGDALLR
AFAQRLTQTMRVTDIIARLGGDEFTIIMEQIGKPEDAAVLAEKIVSAMQQPFELEGITVR
ISASIGLAFYRDEDISPAVLLQRADVLLYRAKQDGRNTYRADTTVA
>A0A2X2W9J3|diguanylate cyclase|EC 2.7.7.65|Clostridium cochlearium|TrEMBL
MVDNKNLINMECYNTWSKQQLVKRINELEKLIKNLKDMERSLIEKNKFLQEISMYDCLTK
VYNYRTIMRIIENQTKYSKDREEVFSILMIDIDDFKSINDKFGHVFGDEILVKICNEINK
NVRKDDYVGRYGGEEFIVIFNNTKLDEAVTIAERIRKSIEGLEILPYLKVTISGGVKEYK
NESCREIIESADDFLYRAKRAGKNRICY
>A0A554WQM7|diguanylate cyclase|EC 2.7.7.65|Tepidimonas sediminis|TrEMBL
MPLSRPRLALVLAALLMAASPPRAAAAGVAAEAAALSFGEVFARHTVPMLLIEPASGRIL
DANAAAAAFYGYAQATLRTMRIQDINQLTAEQVAAERALAAREERNYFLFPHRLASGEVR
PVEVYSVPFEVQGQRLLLSMVHDLSAQRVSDHERWRYQVQLEEAVRRSVQDIERLHRQRL
LLGAAAGVLQLLLIAGLAAWLWRSRQLQREAEAARDAEAHTAAALRAGEARLREELAARQ
RLENLIWGTDLATWEWDLTSDALQVNERWAAMLGYRRAQLEPLTRATWRDLLHPADLQRH
EAALQRHQEGDAPLYEAELRLRHRDGHWVWILERGKVVERDEVGRVRRMAGVSFDITERK
RAEDELALAASVFTHAQEGILITDERTRIVRVNDAFCSLTGYTREEVLGQTPALLRSGRH
DEAFYRAMWDELQRHGFWIGEIWNRRKDGRDLVELMAISAVRDGTGEVRHYVGLFFDITD
QKLREQRLEHEAFHDALTGLGNRLLLRDRLQQAIARAQRHGGTLALAYLDLDGFKAINDT
HGHAVGDQLLRVMAERMRSLVRSVDTVARLGGDEFVVLIADLQDPRQAEPLLRRLLAALA
EPVEYGGQRLQVTASIGVAFLPTSGAHDPDQLLRQADQAMYQAKQTGRNRVHVHGAPDTP
PPS
>A0A2S6UQH6|diguanylate cyclase|EC 2.7.7.65|Alphaproteobacteria bacterium MarineAlpha3_Bin5|TrEMBL
MKRNVLSSKFNTERVRVDDETFLGNYSGPAVILNSEGKPTASNKEGKDLRNFVEKVNPSE
ISKLVLQATSKNIILSDHCLCKIGGVNLLLELTAIPEQSPTRRILLLGRESELYQKKQSS
VSSKYERYKDLAEMSPDFLWEVDSEGRFVFISPKGGLGYKRSELIGRHAKELVIDPEKFN
PFPFLSPYPLDDLDILLRDKNGTVCCVVMSSMPVPEVGIDVVKETGCRGICRNVTKMREN
EAALLRVQHREELLTSIVSQIRNEVEPVDILNTAATATANGLGANGSRVYRLIGGQKFVT
AAEYGELSNPENILNRLKKSKLKGGATTYKTGAREFLIALTHYRQEINGAIVIWKTDVMT
SWNNDHKILIGDIAHQLGLVNEQMTTHERIKKLSRTDSLTGLLNRRAFFEQDIPRRIARL
VRNGESAAMFFIDMDNLKKINDEFGHQFGDKAILLVRDILLQHSRPTDLVARLGGDEFVV
WFDGIDLETSKKRVEQLIKASRSLKNSTGKEISPLSLSVGVACFDPTSDETIEELICRAD
EAMYVAKKAGKGDYFISERKKRGK
>B1LQQ3|diguanylate cyclase|EC 2.7.7.65|Escherichia coli (strain SMS-3-5 / SECEC)|TrEMBL
MENQSWLKKLARRLGPGHVVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHLENVANA
LDKHLQYNVDKLIFLRNGMREALVALLDFTSLRNAVTEFEQHRDEHAWQIELNRRRTLPV
NGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRAGFYVST
QPTLFTRNVPTRYYGYVTQPWFIGHSQRENRHRAVRWFTSQPEHASNTEPQVTVSVPVDS
NNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRFLTSSNPDHPTGNIFDPRE
LALLAQAMEHDTRGGIRMDSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISIALTLLW
ALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLAKLCQTH
QHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEEFCVILP
GASLTEAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQSLADRR
LYLAKQAGRNRVCASDNA
>A0A508WNV3|diguanylate cyclase|EC 2.7.7.65|Sinorhizobium medicae|TrEMBL
MTARILVVDDVPANVKLLEARLVAEYFEVLTAADGHAALAICEQTSVDLVLLDIMMPHMD
GFEVCERLKSSSRTAHIPVVMITALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKNVSDELRLRAQTAQTIGLQELSRLDRPDEPGSVLLVDGRASSQERLTRALRPIADVA
VLSDPQAALFEAAENSFDLVIVNANFDDYDPLRLCSQLRSLERTRFIPILLVTEQGNDEM
IVRALELGVTDYIMRPVDPNELVARSLTQIRRKHCNDRLRASVQQTIELAVTDDLTGLHN
RRYLENHLKLLIDRAGARGRPLSICITDIDRFKRVNDTYGHDAGDDVLREFANRVRATVR
GADLACRFGGEEFVVVMPDTTPEMAAIVAERLRLSVESRGFDIAKAATVLTVTASLGIAS
LRPDGDTAEALLKRADMALYEAKNGGRNRVVAAAA
>A0A2D4WI20|diguanylate cyclase|EC 2.7.7.65|Pseudomonadales bacterium|TrEMBL
MPRLSTEQLSMEWGALNQRFSAHSRVFILDFCQRHAQPLAEHFYQQMLQDPGASPFLSHD
QVSSRLHSSMQRWVAGLFAPQTHEDLLRIIAEQQKIGEVHARIDIPVHLVLRGARAMKVE
FIRLLLADGRLCGDEYLEVARLMSDTIDLAMEVMSQAYASSHDRNSRTEEAYRLFSVTQN
IASEKERQRGALLDWENQLMFGLATGLSIAQLPRIRTCEFGVWFRHKGAHAFEGTPEASQ
IIHGMVQIDDVLLPLFAEEWRDRVPQLREMRDLVSTIRFNLDHLFEQNSELEAGRDVLTR
LLNRKFLPVVLSKQITYARNHGAEFAVLVLDIDHFKRINDGYGHEAGDRVLQQLAALLVN
NSRAGDYLFRLGGEEFLMLLVDTGLNGARRAAEKLRASVEREVFRLPQEQTLSVTMSIGL
ACFDGHPDYQQMMRRADEALYKAKEGGRNQVVQAI
>A0A2S9Y0D7|diguanylate cyclase|EC 2.7.7.65|Enhygromyxa salina|TrEMBL
MLVDAFEDEFQSRLLRAAARATCENGLDFVAVGGGVLGLEQSNPKTFIYDLISAQSVDAL
LIASHVIGHHSTLTEVQDFVDRYTPLPRISLGVELEGIPSLLTDNEAGMHTMVNHLLTAH
GHRNIAFVTGPKASQEADARYQGYSRALREAGIAEDPRLLVHGDFLRESGERAVHTLFEA
RGLQKTEVDAIVCADDAMALGALTALLARGLRVPRDIALTGFDDIEFGRYAPAPLTTVRQ
PIVQQVRHGVRLLASALNGEAPEPVSVTFQSEFVQRRSCGCTVRECDSTPSWSAVDERRD
FALALRSRWDDVTRDLQIAAHGALELVTQAWETRLLNGLLSQLSGETPEAFFEAVEDILN
ALLQQRGEVGACQDVLVALRRHAMRCASTPDDRARLGDLLQEALLMASDTSAISQAQRRA
EALATRRVLGDATTALLVAPDLATLSEIAANHLPQLGIKSAVIALFTEPNRLTEELDAVL
VFNERGRTSLSGQFESRALAPAGFLDGRSVIAEPLGFRGERLGIGLFEYGSYDSILVGEL
RQAISSSVKGALLARALEEAKRKVEALAVTDPLTGLYNRRHLSVRLREEYARANRHQRPL
SVIMVDLDGFKQINDEYGHDEGDKVLKRVAGILGGKVRAVDTVARFGGDEFVIVLSEASK
EIAEKVGQRILDKMEGDLDAHGVVSASLGIATNTFGDNPTTDEEQLIRQADHAMFSAKRS
GKNRVCHFDDCATQSLTPKRFTRSRE
>A0A1C6B1L9|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MFPKYTTALGKEGIVMENNELQYNLRKFEEDENHIEYFISIFPEYIKSNPEKAKEILDLV
MEIALNKEYELAYGWCLMYIGWYCFTISDYTNACKYRLDANEIFIKNNCVKGLIFSYNGL
LADYTRLGNLELAIESGLSGIDLAEKENDEKALIHLMINTAISYMDYRKYDEAKRLLNKI
NEVYRQIQGSELIVYYITLAEVEVISGDINKGYECCEVAIELIKELGCWIYECEILSIRA
EANSKLGKNKEAEIDFEVAIKSAKSFKNIIYIVKTLRRWAKHYNRIGELDKAEKKLIEAF
NEVNSLNSLLDKSEICYELNELYAQLKRYEEAYKFLKEHLEIEKEIFNNKSSSWLARLHN
KEITREAKIYRELYQEIDLLSGIGKKFTSDLKIERNLEVIYEEVKELMEADVFGIASYSK
EEKILKYDLFIVNGKRKNCGISALEEENFGTWCYKNKENIVINDMENEYRKYVPSRNKGI
EDDNCNVKNIKSAIFCPIVVENEVLGILTVQSYKKNSYNKNTVKKLEILASYIAIALENA
KLFKNIEYSATHDWLTDVYNRKEILKRGQTIIQNNKGCSVMIMDIDNFKSINDNYGHATG
DYVLKTISNLMKKDIKGNGYIGRYGGEEFLIVVNSSNKEYVSVLANNIRKNIENYNFIVD
SKKINVTVSIGVYNYLKDDKYFNKHIKLADEALYLAKLFGRNRVVNY
>Q7VTL8|diguanylate cyclase|EC 2.7.7.65|Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)|TrEMBL
MKPSPEILALRWKDTCAHYSPHEWVAARNVVTANKAALADYFYECMLADPNAAFFLSDQL
VKTKLHASMQDWLESVYAAAPTEEYERTVAFQRKVGEVHARIDIPVHLVTRGACALIRRI
CELLDRDASLSAAQAAATCRYVADVTMTAVEMMCHAYSVSHDRNARAEEGYRLLALSQNV
GAERERQRAALLDWENQLMFGLSVGKPWDELPPIRKSEFGLWFIHKAAHAFEGAAESRSV
SSQLQHIDQLLADAQQTQPPPDQRLAILHSVRDATKAIGFLIDGLFEQAGNLESGRDTLT
RLLNRKYLHVVLSKEVAYARKTGVPLSVLVADIDYFKSINDAHGHDAGDFVLQQVASLIA
SYSRGGDYTFRLGGEEFLVVLVDADGTQALNVAEALRRRIQEKATVLPDGGEVRLTLSIG
VAAHDRHPDYQRLLKRADQALYAAKSGGRNRCVLANAGPAEPSQRPDAVAQSGQH
>A0A1C6JMQ0|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MYTVEEIKNKVKTGTWTKEDVARCVEELKQISDFIVYTEEIYYISYGIFAYNFREYAYSL
IEICREAGVHMERSKEKSRLYLALVRLYFCLGFPPKIVEYGLKYANSGFTLRSPLKSVYN
TIVAAFSDCGLFFEADFYLEKMMDISRLDPCDSSVDFWNSDTLNELVYYDSKVYVKLGMG
DVAGAEQASVDMQAILTEREIPEDGRAFFLLQKEFTDLYLRLYQQKDKAVIAEEFNNYMK
KMEAGEGARDTLSFCVCYFGEFLQVMAEEERWDDIIRIGNYIKNARNFSGSFCPVYKLMR
TAACRSDREELRRQIPEFERMYLEALEQEKENYDQMVRLLTREELRIERLKTSMERDALT
GCLNRAAFDHNSKRFMKNHKKGSLVFIDLDYLKLINDCYGHENGDRYLVCFAENMKCAMD
RQDLLYRYAGDEFLILSALEPEQIQERLNEILEKSPIHFDINGEIRNISFSYGIVAFEEK
KGKIADLVKEADQRMYQCKSRNHERISKRGAAE
>A0A1C5QKM5|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MRINSVEQKGYANGIMDWKIFVRQDLVVAKASEFFYEFVGENSFRPVSELLLPEDGELLK
KAVEADTFQPLELITVLHNLKDSVRNVYLRLEQSEQTENGIPLYQITVSDIHDLENRNLR
LEQSILKYRHFMTLEDVYFFEYLIEQDSITVYKYVNERAMNQFEGPMNALIRNVEQAHEG
SDISRLEDQLRIFCAHLRNGDDFFEMEFVSGQEDKGIWKVKGARIPKKRDMVAGIITPDR
NREKEAYYLTPAARDAGTGLLNKRAWTEYTIEQLNCKDHSTRWLVIIDIDDFKHINDTYG
HIFGDQVIRRVAEIMQVLVGQRGVIGRFGGDEYVILLEKVETREQLKTLLKTIAKEFALA
FDPKTHVTASIGVSEYPVDGSEYEELMRKADKALYLAKEKGKNRHIIYEERLHGKLESDD
MQNMAMAYAVSKEKKREVITKMITELCVSDVNSIVKKEERLQQIRSLFDLDGITIYSESG
AQLVCRNGNYMVEVPDGRGLFEDEKYLALFGDDDNFIESNTLKLRSQDPAAFAVMQKQEI
GAFLQCLCRKEGVPNVIVNYDVFNRNRKWSDEDITLLTILGHCIGNLLNYSE
>A0A1C6FI36|diguanylate cyclase|EC 2.7.7.65|uncultured Clostridium sp|TrEMBL
MKQKTLIPLIVFLLGICLVGIILYKVDSHETAQNHTTALLNATTYGERIKNEITEGIDVT
DVLKQILISESGEFNQFDMIAENLMSDSIESVQLAPNGVVTDIYPSTGNEAGKIDLLHDK
DRGKISCYARDNHTIITQGPFKLKQGGSGIAVRNPIFLKDENGLEYFWGFTIVVLRVPDI
FSDAVSALSSFGYEYRISKTDAPWSDTYNIVSQSNDSLINPVSYTFTIGEEEWMFEVAPQ
CGWRNNLLIAKTSVILTANVILLSVLTCVWLTSKENKNRFQILAHTDSLTNIYNRYGFDE
LAAKMIAKNPKTHFVAALFDIDDFKFINDIYGHGYGDKALKCLADSMKAFFPSDAILGRN
GGDEFCVLLPNYTFEEAEAQLQQFTSLPKTFSCRGREQQFYISLGYAEYPTFASSLSQLM
RCADAALYEIKLHGKNGCMSYSKELQSVVRKQLGFALKDISEHLPGAFIIYRADKEDDEL
FYANHEFLSMTGYQSMDEFFRLTNKSFHNLIREDEQQQIEASIWEQIDSGNENDYIHFHL
RKADGSYLSVLDHGRIVESPQYGKVFYVLFMDWEDMHIHYSDKFSG
>G9A4M1|diguanylate cyclase|EC 2.7.7.65|Rhizobium fredii (strain HH103)|TrEMBL
MTARILVVDDVPANVKLLEARLVAEYFDVLTAGDGRAALAICENRPVDLVLLDIMMPDMD
GFEVCERLKANSRTAHIPVVMVTALDQPSDRVRGLKAGADDFLTKPVNDLQLMSRVKSLV
RLKNVSDELRLRAQTAHTIGLRELAHADRPDEPGNVLLVDGRASSQERLQRALKPIAEVA
VISDPQAALFEAAENSFDLVIVNANFDDYDPLRLCSQLRSLERTRFIPILLVTEQGSEEM
IVRALELGVTDYIMRPIDPNELVARSLTQIRRKHCNDQLRASVQHTIELAITDDLTGLHN
RRYLDSHLKLLIDRASARGRPLSICITDIDRFKLVNDTYGHDAGDEVLREFAKRVRATVR
GADLACRFGGEEFVIVMPDTTPEMATIVAERLRLMVEGRGFGISQGDTVLSVTASLGIAT
LRPGDDTPEALLKRADMALYQAKSNGRNRVVAAAA
>A0A245ZHP7|diguanylate cyclase|EC 2.7.7.65|Sphingomonas dokdonensis|TrEMBL
MSTTPARRRASLLLLGVAYFVLCAGTLRLTRFDGGVAFIWVAAALLTARLTTLPRERWGA
PLVICGLASFTATSIWGFGPVLALPLALINVLESVIGAILLRRLAPRRSVLESQRWLLVF
VLAAGVVAPAMSAILATITLTIATDQLPLKSLINWYSGHALGTLTFMPIFMLVLRGDALR
LIRQTTLAQLSQATVLLAFTSVISIVSFAQHGLPLLFLPLLPMVLATFRGGPLSTAASIV
MLAVIGGAFTLLGYGPIARIDAPTGARMQFLQLYIACAMLMVLPARAELQQRANLFRKLR
ESEARYRVLTEHSTDIVINVDRQGLLRFASTSIRQISGSSPDQLIGRPIATMLRGPDADR
IAGFLDQIIAEPEQPHIHEFRAISRNGDMRWLETHSHAVMDDAGQVSGVVSAIRDVSKRK
AHEERLAHAALTDPLTGLANRRGLDAELTARLSSGVGGCLALFDLDHFKRVNDTFGHATG
DEVLRRFAALARASVRDQDLVARLGGEEFAVVLPDISMSQATFVCDRLRRAIGDAGMRVN
DQLIALTVSGGVAMFGRDQTADAVLRAADAALYRAKHAGRDQVALAA
>A0A0S4HUF6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. URMO17WK12:I11|TrEMBL
MVPKNLHDSSFAQSPDTAQTLMALMHAQSEVARLSEREQLFSSLLVSVNAVLWAFNWETR
QVLYVSPAYERIFGRSAGSLLSDYNEWRDSIYPDDLDYAERSLADVLVKGAVEDREYRII
DADGQVRWLSDKCFINRQAEPGQPVIIVGIAEDITEKKRMEAELQRLATTDVLTQSSNRR
HFFECAQKEFAQARKQGTPLAFLLLDIDDFKGVNDTYGHPQGDVVLQQIAESGRAALRRG
DVFGRIGGEEFAAVFPGCAPDMALQVAERLQRQIQQLSFSHDDQTFGITVSQGLTSLTNE
DESLDSLFARADAAMYEAKRQGKNRIISG
>A0A3P6M2E7|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFG
WRGVVPVLCGMLCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRY
VWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYN
MLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIA
GYLVPVFFIIVTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLIS
FSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNL
EFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNI
LNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEM
VSGQTTKQVLLLNTIRTALYQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLP
LIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRY
HISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFWIAIDDFGTGYANYERLKRLQADII
KIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYL
IGRPQPLAD
>A0A3R0XID9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MSRINKFVLTVSLLIFIMISAVACGIYTQMVKERVYSLKQSVIDTAFAVANIAEYRRSVA
IDLINTLNPTEEQLLVGLRTAYADSVSPSYLYDVGPYLISSDECIQVKEFEKNYCADIMQ
VVKYRHVKNTGFISFDGKTFVYYLYPVTHNRSLIFLLGLERFSLLSKSLAMDSENLMFSL
FKNGKPVTGDEYNAKNAIFTVSEAMEHFAYLPTGLYVFAYKKDVYLRVCTLIIFFAALVA
VISGASCLYLVRRVINRGIVEKEAIINNHFERVLDGGLFFSAGDVKKLYSMYNSAFLDDL
TKAMGRKSFDEDLKALPEKGGYLCLFDVDKFKNINDTFGHLLGDEVLMKVVKILKSQIPV
DKGKVYRFGGDEFAVIYTGGTLEELLSILKEIVHFQVGSINLSTSIGVAHSNECTTVERL
KMLADERLYKSKKNGRAQISWQ
>A0A8H8ZLJ9|diguanylate cyclase|EC 2.7.7.65|Shigella dysenteriae|TrEMBL
MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQ
VERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILY
PVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEE
EKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISR
LIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVL
TKLLNRRFLPTIFKREIAHANRTGTPLSVLIIDVDKFKEINDTWGHNTGDEILRKVSQAF
YDNVRSSDYVFRYGGDEFIIVLTEASENETLRTAERIRSRVEKTKLKAANGEDIALSLSI
GAAMFNGHPDYERLIQIADEALYIAKRRGRNRVELWKASL
>A0A7Z7HTV1|diguanylate cyclase|EC 2.7.7.65|Sterolibacterium denitrificans|TrEMBL
MKLTASLAAVLRHGLWGNLLLALVYLISAQLVRTLLAAQGQIALIWPPSGIALAVLLLAG
NRYWPGILAGALATSLWLAGSQALTGLLIACGALLEALYCAWWLRRQTDFSVKFEQLNDF
RHLIMAALVGTLISAGFGNLALLIEPHPAHDRLGLSLLQWWQGNLLGVLLFTPLILVWRQ
SPWRDWFRSGRMRILEWGTFMLLTFLVGQIVYVGWWSEIFAPIAQSYWSLLFLIWAAVRF
GRHGVLLMLAINGAQGLLGVSQGSGYFADDLARTGLMNLSFSYLLATLTGIALSLVTHER
NQVERSLSDQAELADGIIQSLPGMFYMLDESNRLLRANRRLLEETGHEAHQLIDASIDRL
LAPEAREQTMNSLQQARSRGEIQGETLLLRHDGKSLPYFFYARHCLLAGQPRLLGLAYDI
SERKQMEEALRSSEQLFQSAINGAGDVVWDWDVATHRISHSARWNQLLGYAEDVPANEIG
NWDERIHPDDLEAARKNNAALFDGKTETTMMEIRLRDRDGQWKWILSRGMVMQRDERGLP
LRIAGTLTDISQIKEQQQQLERIAHFDSLTGVPNRFLLNTRLRQTLGAARPHGSLIAISY
LDLDGFKEINDTHGHDVGDSMLVAITQRLRRVLRECDTLARIGGDEFVILMAELENETAC
HVLLERLLSAVAAPVRLNDLKLQVSASIGVTLHPTDASDADQLLRHADQAMYRAKQTGKN
RYCIYGAGEIN
>A0A378GN07|diguanylate cyclase|EC 2.7.7.65|Kluyvera ascorbata|TrEMBL
MMSSHSRRLSFTTPIFISFAGILLSFIIIAALVTVIQRNDIIRDYHGINRNFTHNLAVNY
TESILHENDYILGRAATYLARDDELNRLVNLDPVQGQQSMMQLLSMMPTVSSLSIADTEG
HYMRAPQVVQRQNAPVFDATTRPWFVHQGDAGVFSRYTQPYVDFFTQHQTVTLAKPVIST
DGKLKGTLAFHFDLAAMSHTLRQMRPPVQGEFFVVNRQGQALLHSDNGKLFQKVISPQIL
SGMTAGEGEVFDKGSRTWYYYYSFTNPDWFVIYKVSGHTLSMLAQHESIIISWGFALAGL
IIITFGLYLRHASRGILMNIINAIKTGDTNRAPGLEVMLHKAIETNKERERAYVRQATVD
SLTGCKNRWAFDTDMTALMAERQPFSLALVDIDNFKSINDTWGHLSGDIVLRNVAREGIT
ILQAHGLSLYRYGGEEFAVIFTAEHIAEASALLELWRINVANRNWREEGLHVTFSAGLGE
WHMETLDHLVSSVDEALYKAKRQGKNRILRTTHDA
>A0A0B7DC80|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MFTKRRSSLAGFIILAVGLVGFSALLLLKSETQRTEKRFSEYVQNISGIVRKQLDTNEAV
LAGFSAFLQAVDQSDTDATARYAAAVLSAYPHIYMLEAARAVPIGEQAAFEDLLRRTWRP
DFELKDFPSLTHQPAQPQVYLSETWPVLFMYPLLPESSSIYGVRLETVAYLSYALARTHS
SQKPVVSPVFSMYEGGSAYILMQSVSRPEQARENTRPNFFGSTMVSLLLIKTSALQDAVN
YANVDPLVSVSAVLKTAAGSESNVFTTEIKQAGILDRLLLPALADRVEITSSSQPMTLLF
ERQLRLGDILTAETLIILAVLAGAFVLMPVVLIRHFKAIERAEIELERSAYLATHDVLTQ
LPNRYLFADRFDQALSNWTLSGTAFAVLLIDLDHFKDINDKHGHEVGDQVLKAVANRMLQ
VTRSCDTVARYGGDEFVILITDLINPESAEQYAERVLETIAQTVATSAGELTLSCSIGVS
LCPNHGQSLSSLLKAADQAMYGVKQLGRKGVAMTESPET
>A0A5E7FQ63|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSLFKRGTRPTLRSVIGRGHLTVALVGVAMASVSLTLLGVLALRVYADHNLHLIARSINY
TVEAAVVFNDKSAATEALALIASTEEVADAQVLDRQGRLLARWQRPETGLISDLEIQLAK
AFLEKPINMPIVHQGREIGSIVLIGHGASLMRFLLSGLMGIVLCTAISAWVALYLARRQL
RGIIGPLRSLASVAHAARSERAFDRRVPPATIAELDNLGSDFNALLDELESWQTHLQNEN
ETLAHQASHDSLTGLPNRAFFEGRLMRALRNANKLNERVAVLFLDSDRFKEINDNFGHAA
GDAVLVAVAKRVRAQLREEDLVARLGGDEFAVLLTPLHKTEDAERIADKIIASMDAPIVL
PGDHQTLTSLSIGIAVYPDHGVTPGTLLNAADEAMYQAKRLARGAQHTAGSEHPVADV
>A0A0B7D2T8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MRLFRSNTRPTLGSVLGRGHLTVALVAVAMASVSLTLLGVLALRVYADHNLHLIARSISY
TVEAAVVFNDKAAATESLAMIASAEEVADAQVLDARGQLLARWQRPETGLISELEMQLAR
AILEKPIDLPITHQNREIGRVLLTGHGGSLMRFLLSGLAGIILCTAISAWVAIYLARRQL
REIIGPLRSLATVAHAARSERALDRRVPPAQIAELDNLGNDFNALLDELESWQTHLKSEN
ETLAHQASHDSLTGLPNRAYFEGRLIRALRNAGKLKERVAVLFLDSDRFKGINDNFGHAA
GDAVLVAVANRVRAQLREEDLVARLGGDEFAVLLAPLHKVEDAERIADKILASMDMPIAL
PGDASVVTSLSIGIAVYPDHGVTPGALLNAADAAMYQAKRLSRGAQSTAGSEYPVNPVQT
RS
>A0A379J8F1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MLHIPTLLIVAVFVFCLMGLLTVHAWHRVREPTLGYLGVMLLLASLGTALMVVRGVGVDF
VALVIGNVVLLMSAAMNWTAMRLFVQGKPHLPGILAGPALWLVMCLVPQFYGSMSSRVTL
YSLIAASYGVLSALELWRHRQHLEVAYLPAVVLMLLHTTFYCVRGVLDPGMPYKDPNALM
NDGVQLFSFMLFESMLYAIGIAYVTLAMVKERAELNFKAAAFTDVLTGIGNRRAFMLHGE
QLLADSMQRGQPVTLLLCDLDYFKRLNDSFGHPMGDQALIAFSQLTASILRKHDLFARIG
GEEFACLLANTDERGAVQVAERIRQRFAELDLLAPGFLSVSIGVVTTTPACHDLSRLLSQ
ADQALYRAKDQGRNRVQTACNTLQAIAP
>A0A5E7SAS2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MAKAGGKGSSLARRLYTSRILGLALGLVCVSAAMYPLDPAPWVWGFMWFNGLVWPHLAYQ
WARRAKTPYHAEHRNLLIDAFLGGFWIAAMQFNPLPSATTISMMAMNNVAIGGSRFLLAG
TASQILGVGVGMLIFAPAFIPATSAVQLYACLPLLCLYPLALGWICFRQAHTLGCQKREL
LALSRTDSLTGLLNHGTWKDQLEIEFQRCNSQQKGGAIALIDIDHFKAINDTYGHVAGDI
VLRQLSKMLKQNLRATDVAGRYGGDEFCVILPDLPLNRAAAIMDALRARFAILGYEQNPA
LKVSLSIGLASFNPAHADAMLWLNDADHALYEAKTTGRNRVICCGNGKPHRELLDSV
>A0A5E7C0P1|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MEVDANAGPMKLLRQHSRPTLHSVIGRGHWIVAWVAVAMTSLSLSLLGVLALRVYADHNL
HLIARSISYTVEAAVMSDDKVAVTAALALIASTEEVAQAQVFDARGRLLTRWQRPESGLL
SELEMQIARAFLEKSITQPIFHQGREIGSILLIGYGGSLLRFLLSGLAGILLCTAVSAWV
ALYLARRQIRGIIAPLRHLASVAHGARIERAFDRHVPAVEIAEFDSLGNDFNALLDEMET
WQTRLQDENQSLAHQASHDSLTGLPNRAFFEGRLIRALHNAKKFDERVAVLFLDSDQFKR
INDNFGHAAGDAVLVAVATRVKAQLREEDLVSRLGGDEFAILLPSLHNNEDAERIAEKII
ASMDLPVQLSGSTSILTSLSIGIAIYPDHGASPGALLNAADAAMYQAKCLSRGGQHTAGA
DLPAANVQTGG
>A0A0D0SQ15|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens|TrEMBL
MSGTKVRPTLRSVIARGHMILALVAVTLASVSLTLLGVLALRVYAEHNLHLIARSINYTV
EAAVVFNDSAAATEALSLIASTEEVAQAEVFDINGKLLARWVRPETGMLSRVELQIAHAL
LEQPISQPILRQGQTVGSIHLVGHGGSLLRFLLSGLVGILICTALSAWVALHLSRRLLNG
ITVPLQRLAAVAHAARSERDFDRRVPSAQIAELDSLGSDFNALLGEMEAWQSHLQSENET
LAHQASHDSLTGLPNRAFFEGRLIRALRSAAKVNEQVAVLFLDSDRFKDINDSFGHAAGD
AVLVAVAERVRAQLREDDLVARLGGDEFAVLLAPLHKAEDAQRIADKIIASMDVPIPLPG
NTQVLTSLSIGIAIYPDHGATPGTLLNAADTAMYQAKRLSSGGQQTAESERPVVNVQHRS
>A0A1C6GJC2|diguanylate cyclase|EC 2.7.7.65|uncultured Ruminococcus sp|TrEMBL
MINKRKTVGVFLCAITSEQKKELCRSISRAAKDLDYNVIFFSFIGTIGADYRNYAQNEHK
MLDIIPFDELDGIIFDNSNSFTDDIKNKIMSHIKKCRCPVVTIGEPCNDYYSVHIDNSEG
IKNMVRHFAKHHGFKHIGFMSGIPGHCDAVERYAAFQSAMRECGLPEDGVGVFHGDFWYN
KCYEAADFFLNCCPRPQAIVCANDYMAYSLCDVLIGKGVNVPEDICISGFDGVYEAKIHV
PPITSAQVNLNTLSRTAFEIIENVNNGRPQEKCVNLYTDSCFTGSCGCNVNYYKTEADKS
REINSLFRKNTFTLYHIYSVEAAMLEMNRVTKIEQISDILSQFGGNIGDYEKFFMFTFTD
RKGRSSFETEIRSPSEQVYPAIWIDRSGSSLRPEKYFSTNTLIPADSAKSPCCYYISYIH
FENHCFGYSAISMKNDEPFSEFYNIWIANIAVALETLLHKNSIRELVEDLEIASTHDKLT
GMYNRRGFEKCMNKAFDEKKEEQQSTVAAIVIDMDRLKSINDVYGHTEGDYAINSLAHII
SACCTENEIAGRTGGDEFYVFAFDYSEEKAMHYKKRFNAALDDFNKTENKPYTLNASIGI
YMADISQHTLPEDFFKRADEEMYAMKREHKVRELQTKI
>A0A5H6P5J2|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Adjame|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A3U8PEF4|diguanylate cyclase|EC 2.7.7.65|Salmonella berta|TrEMBL
MPHETLLDNQGWFKKLARRFGPGHVVNTCFLIVMLFSTLLTWREVMILKDAYVASQRNHL
GSVANVLDRQLQFNMDRLIFLRNGMHEALVAPLAFSALQSAVTQFEQRRVRHFWQLELDK
RRTLPLYGVSDQFVARTTLLSRESRDLANELTATLELGYLARLARSSAMLTLETMYVSRS
GFYLSTLPTAYGSDIVSRYYQYVTQPWFIEQSQRRNSQRGVRWFTSAQPYVTDEQKKVTA
SLPLDHDNYWYGVLAMDIPVASLQRFLRDAAEKDIEGEYQLYDNHLRLLTDSAPEQQTAN
TLNDRERALLAREIEKDTLGGLRLGTHYVSWERLDHFDGILLRVHTLREGIQGNFGSISI
ALTLLWVLFTAMLLISWGVIRHMVKNMFVLQNSLQWQAWHDPLTRLYNRGALFEKASRLA
KRYREARQPFSVIQLDLDYFKSVNDRFGHQAGDRVLSHAAGLIGSTIRAHDIAGRVGGEE
FCIVLPGATKAQALQIAERIRQRINDKEILVTKSTTLRISASMGISSAEEYGDYDFEQLQ
SLADKRLYYAKQSGRNRICASDATQEREKK
>A0A517ZXE8|diguanylate cyclase|EC 2.7.7.65|Symmachiella dynata|TrEMBL
MIDPETIWTSKHLPTLPSVAVELLKLRNDPEAGIAEVQALVRNDPAISAKILKAVNSTFF
GVSSQVTSLERAVSLLGGTYVTSLALSFYLSQHASTTGPLSEYYARYWLQSVVQATAAET
LGRRAKQRMESELFLAGLLLDLGQLAMLKAIPDEYQAVMTTAATQSRDLYEIEREQLGFD
HMEIGVKLAETWELPETLWKFIGSHHAAVEEPETSEDPATHSQERALALAACVGDFFCAN
SLGIAYERLQKRAAHDYEMDEQELEEFLNEVRARIEDVADQFSAQANQLEDPAELMAQAS
EQLANLVMQESVANLHATARHEAAVQAKHDLESQHHELQQQSQYDRLTTAFNRAYFEDAL
DTEVGRCVQTAHPLGLIFCDIDQFKQANDTYGHQFGDQILKQVAAAFLEVLRPDDILARY
GGDEFVVLVSNPTLKGLEKLAERIRLRIETEQFEIDGCPLTICVSLGAALDIPGRSCVDV
GDRVIAAADQEMYKSKHAGGNRSQVRSLICESSARLEQLVTNNRFSRWLVANQILDIPVV
SRALLQVTGQKAQIGQLAVSCKVLRSVDVQTILAEQECTGERFGEVALRLDLLSEDQLVD
LLILQREDPSALLQAIASQDILSRVELQCALEAYATSRTDVICSEFFASSPTTNQTTDSV
PSPSCGIAPADPR
>A0A7Z7YIX0|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MDNDNSPDKRPTFKRALRNISMTSIFITMTLIWLLLSVTSVLTLKQYAHKNLTLTAATMT
YSLEAAVVFADGLAATETLAALGQQGQFSTAEVRDNQHNIIASWHYTAREPGDTFSNFIS
HWLFPAPVIQPIRHNDKIIGEVQLTARDSSISHFIWFSLAVLTSCILLASGIAITLTRHL
HNGLVEALKNITDVVHDVRSNRNFSRRVSEERIEEFHRFALDFNSLLDEMEEWQLRLQAK
NAQLLRTSLHDSLTGLANRAAFRSSINALMNDSDTRKTSALLFLDGDNFKYINDTWGHAT
GDQVLIAVAKRLTEFAGKRHQAYRIGGDEFALVLYSVQSEYDVQHICTALTQTFNQPFDL
HNGHQVSMSLSIGYAMTCEHASVEKLQELADYNMYQAKHQHAEKLVK
>A0A8H9ESW0|diguanylate cyclase|EC 2.7.7.65|Escherichia albertii|TrEMBL
MSKQSQHVLIALPHPLLHLVSLGLVSFIFTLFSLELSQFGTQLAPLWFPTSIMMVAFYRH
AGRMWPGIALSCSLGNIAASVLLFSTSSLNMTWTVINIVEAVVGAMLLRKLLPWHNPLQN
LADWLRLALGSAVVPPVLGGVLVVLLTPGDAPLKAFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLFETLLTLAITLTLSWLSMLYLPWPFTFIIVLLMWSAVRLPRMEAFLIFL
TTVMMVSLMLAADPLLLTTPRNNVMNNMPWLPFLLILLPANIMTMVMYAFRAERKHISES
ETRFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRALTFQQLTWPEDLNKDL
QHVEQLVNGEINTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKRT
EQVNKQLMERITLANEAGGIGIWEWELKPNIFSWDKRMFELYEIPPHIKPNWQVWYDCVL
PEDREHVEKVIRDSLQARLPFKLEFRIAVKDGIRHIRSLANRVLNKEGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPL
LTVLHITFGDNGPLMENIYSADTLRSAIEQDVVLHCRNGGSYDVHYSITPLSTLDGSNIG
SVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFID
LDHFKAVNDSAGHAAGDALLRELASLMLSMLRSSDLLARLGGDEFGLLLPDCNVESARFI
ATRIIGAVNDYHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNDGRGRV
TVYEPQQATAHSERAVMPPDEQWLMIKENQLMMFAHGVASPRIPETCNLWLISLKLQNDE
GNVIDEHVFRHGLSDPALSHALDRRILHEFFQQTAKSAADKGLSIALPFSVAGLSSVTLV
DELLEQLEKSPLPPRLLHLIIPAEAIIDHAQAIQKLRLADCRIVLSQVGRDLQIFNTLKA
NMADYLLLDSELSTSVQGNLMDEMLISIIQGHAQRLDVKTIAGPVALPLVMDTLSAIGVD
LIYGDVIVNVQPLDLLVDSRYFAIN
>A0A2C9ER61|diguanylate cyclase|EC 2.7.7.65|Pseudomonas protegens (strain DSM 19095 / LMG 27888 / CFBP 6595 / CHA0)|TrEMBL
MKQKRTFATPRLLGIVWPFIAVVLFQALLGGLSLYVLSAVRGYVAGESLWSKGQKDAIYY
LNLYADSRDEGTFLKYQNAIAVPQGGHELRVALDHQPPDLEAARLGILKGGNHPDDVSSL
IWLYLNFRHFSYLEKAIDLWTVGDGYLLQLDTVAREMHQRIGSNSASEGDVQRWKSQIFA
INDGVTPAAKAFSDALGEGSRVILRLLLVTNLATALVLIALALLRTHKLLAQRHAFADAL
QLEKERAQITLQSIGDGVITTDVEGAIAYMNPAAEDLTRWKAEQAVGLPLAALFNLLDEN
AQADGFTLIEHILSGQLSGGSEHSKLIQRLDGSTVSVTLVGAPIRNAGKVSGTVLVLHDM
TQERQYIANLSWQATHDALTGLANRREFEFRLEQALHSLIRQPARHALMFLDLDQFKLVN
DTCGHAAGDELLRHICALLQSGLREGDTLARLGGDEFGILLENCSPEAAEKIAEGLRQTV
QNLHFVWKGRPFVTTVSIGLVHIAQTPTTLEASLRAADMACYMAKEKGRNRVQVYHADDS
ELSLRFGEMAWVQRLHMALEENRFCLYSQEITALGHVERGGGHVEILLRLHDEAGRMILP
DSFIPAAERYGLMTSLDRWVVQNVFKIIAQCIAEGREGPMAMCAINLSGITIGDDAFLDF
LREQFVVYGVPPKLICFEITETSAIANLGSAIRFINELKGLGCHFSLDDFCAGMSSFAYL
KHLPVDFLKIDGSFVKDMLDDPINRAMVEVINHIGHVMGKRTIAEFVETPQIEQALLEIG
VDYAQGYIIERPQLFTCDSLQCRPVRPQPLLFKAPGTFR
>A0A6W0M7P7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Duisburg|TrEMBL
MNKEFSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6C8LMQ1|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Lubbock|TrEMBL
MNKEFPLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTLKQYAQKNLDLTAATMAH
SLEAALVFSDNAAAAETLATLGRQGQFSAAEVRDKNGRTIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDSLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKGNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLAEFGGSRYQTYRLGGDEFAMVLYDVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHATAEKLQELADRNMYQAKHRRAERSLN
>A0A6W0LYX8|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Duisburg|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
SQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQLTLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A4R8S4M5|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MAAFSGAGGVARTLPLGDMSRWWSSPSRYDLMMSYFSTRSMRLALRGAVGGSAGALAIIP
LAMEFSPMGPRTGVWRSLDIVSSLLAFFWMLRWWFGPLPKESESAVFSVSAVASVCIACF
ADSDRGTGMHGLIALSLMAIYICSFHGARLIALYLFVSLATLAFLAVAIDLQHGWAVAVA
DSVVTATLLVGVPPFIHFAQLALTSDARAAAIDPLTGLHNRRGFDDQSTILAHAARTDRS
ELSIIMIDIDRFKQINDRFGHGVGDQVIADVGSHIKAISGDEAVVGRVGGEEFCVALRGP
AAQAREVAEQIRAGLESLDAMVTVTVSVGLATSPPPTSSTAPDNLIGQLVADADHAMYSA
KRQGGNRLEAWDLSG
>A0A6S7E3T7|diguanylate cyclase|EC 2.7.7.65|Achromobacter anxifer|TrEMBL
MSASNEQAWVAIYQSVDAYTRGQVAAVVSDSLTELVDAFYSTLLSDAEAGPRLSHEIVST
RLHAGMRGWLRGLLCVREQGDIADLMATQKKVGEVHARVHIPIHLVMAGARILKNEIALR
LRASDLDGMAASVATQYVCNLFDLAVEQMSRAFMRDINRGARNDEAYRLFALGQNISTER
ERQRAALLEWSQSVLIGLHYRAPGQSLPRLAASEFGLWLQHKGGAMFESAPGLLQITEAV
AHLDGVVLPRLMRDEAQGQTAAMPDHVRELQEQVARIKHLLNGLFDMVAEIESGSDPLTN
VLNRRFLPSVVGREISIARRQRTPFSVLLLDIDHFKSINDQHGHSGGDQVLRQFAEVLHQ
SCRSSDFVFRYGGEEFLVVLVDAGREAALAAAEKLGAEIRRHVFNIPEAGPQHITASIGV
ATFDGHPDYAYLIDRADKALYEAKQAGRDRAVAA
>A0A1R4B0X3|diguanylate cyclase|EC 2.7.7.65|Vibrio palustris|TrEMBL
MDHSSKQDVTDTWKLVDKVLSLVRPFGAITVLFGIISLAGYFGSIEGLYRPIDNGPATHP
LTALIIVLLGFSLYKNVQTPLEIKQRHLFAFLAFIFTVIRLTDVVYQSDFSQYITPFLSD
VLRELQTGKSNYMGGNTALMLLFISSSIVAYNFKKYVFSQMIATIAVSMPLITILGYTYG
LTKFYGQMSLFTATAGFALSVATVALTADKGLVHALLSPHIGGKVARFQFVTGYIFPVVI
GYFIVKLTVAPQGSLFGVFVVGVCWFIMIMVGISALVVEKVDHKRRLDEEKLHQAATTDS
LTGLFNRRVFFDAANHEMARLKRSGTSLSVLMLDVDFFKKINDKAGHAMGDQVLIQLSQV
LNSSLREVDIIARVGGEEFAIILPDTSQEGAQRVAENLRRNVEKIVVANWTPIYGPVTIS
IGVAMVETNTQQTFDEILANADKALYQSKANGRNQVSLYQIDGC
>A0A4R8SU02|diguanylate cyclase|EC 2.7.7.65|Mycobacteroides salmoniphilum|TrEMBL
MHNRQQLEPGFQYLLVTDALRGAGQLRQLKVGIGLLCFSIVILAGATQFNTLGPQGLWPR
TIQAIAAAIAVIVGLCWIMFPWPSRRGMVAFVAWADVTLAIAAALFSDPTARLCAVAYLG
LVGLLPTFFLGRRALVIHCGFALALFGVVVAVNVLVDGATLSAQFTYGAPALSAVVLMPV
IIQLVLEGGRDSILAAAVSANRDPLTGLLNRRGVTTAIDLLHRGRIDAVDVVVVLMDVNG
LKELNDTRGHGAGDAMLKAVAAMLTASTRVGEIAARIGGDEFLVVAFPGRAENIDTTIRR
VSTPRAGIDTWSVSVGAAWQSQTGGKVDLDSLVQQADYELYKVKSSRGMLDPQH
>B6BKL4|diguanylate cyclase|EC 2.7.7.65|Sulfurimonas gotlandica (strain DSM 19862 / JCM 16533 / GD1)|TrEMBL
MRTKAKLLFIVAIMLLGLTTATIINISLNFRDYSIKSAIDKSKMTATIVKDGLTAHMVNG
IMDKREYFLNQISANNEAVKSLWLVRSENVISQYGQGLNDETVRDEIDKKVLETGQTVRE
IIENSNDITLRVTIPYKATVNGGNTNCLTCHNVQRGDTLGAISMEFDISDMRTSGMLTIL
KILGINMLFLVIVLFLLNHYVTPYMKLFTCMQDGIKKAYSGDFTHKFETTVSGDGKNIVE
QMNTLFTKMQETFGDIKYNLATFIPQGCVSSADPLHEAKTIINELSDVYKFKKTIELDAS
KAEVYTRIIDILILKYNLKKFALYEVNNVTHERTLFFSTGKDALICQEKVNKDASECRAY
RTKSVTISTEFPNLCQVCLSEKQNYICIPFTINNDVSLSISITGDSPAEIEEITSYITSI
KHYFEAAKPVIESQILMEKLKDTSLRDGMTGLYNRRFLEEVIDKIMHQATRSKETYSVLM
LDVDFFKMVNDTYGHDVGDRVIVEIGKVLKDNIRDADLAIRYGGEEFVVMLHNASDEGTQ
EVASKIHSAFAALSFDVGTGEMMKKTMSIGISKFPKDGDTIWKCIKFADTALYVAKTTGR
NKIVHYEKEMGESGELR
>A0A3N1XAP7|diguanylate cyclase|EC 2.7.7.65|Comamonas sp. BIGb0124|TrEMBL
MPRNTSPEQLAREWRTVCERYTPEVRERVRSTVAAQREALATAFYDQMLLDQAASFFLSD
QLVKSRLHTAMQAWLVEVFEAGVNGDFEHIVARQRMVGEVHARIGIPAYLVMRGIRQLDH
EIYDLLNGDAHAVQMAAATYVAETTGLAIEIMCHSYSVSHERNARAEESYRMFAMAQDIG
AEKERQRAALLDWENQLMFELSTQISAAVNPPEGDGGVQRASPSGGYWPDLPMIAKSEFG
LWFLHKAAHAFEGAADIKTIGKQLEEIDELLRPPGPLDASAARTSLSGLMVAVRGRAKTI
GFLLEQLFQQASHMESGRDALTRLLNRKYLQVIMTREIDFARKNDSPLSVLALDIDHFKR
INDSYGHDAGDVVLQQVAQNLTHIVRSGDYIFRLGGEEFLVVLVDVDSHRCRTIAESIRQ
RIAAERLQLPNGRAIDITLSIGIATHDGHPDYLRLLKTADDALYDAKNGGRNRVSGGTHG
LAV
>A0A729K967|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. houtenae serovar 18:z36,z38:-|TrEMBL
MNKESSLSRPTFKRTLRRISIISVLLTMTLIWLLICVASVLTFKQYAQKNLDLTAATMTH
SLEAALVFSDNAATAETLATLGRQGQFSAAEVRDKNGRIIASWRYDARAADDKLIGLISH
WLFPLPVSQPVWHNGRAIGEVRLVARDNLIGHFIWLSLAVLTGCILLASGIALLLTRYLH
NGVVDALQNITEVVHDVRTNRNFSRRVPDERIAEFHLFAQDFNSLLDEMEEWQLRLQAKN
AQLLRTALHDPLTGLANRAAFRSCINALMKDNSARSSSALLFLDGDNFKYINDTWGHAAG
DRVLIEVAKRLTEFGGSRYQTYRLGGDEFAMVLYGVHSEYEVQRICAALSQAFNRPFELH
NGQRITMTLSIGFALTWEHTTAEKLQELADRNMYQAKHRRTERSLN
>A0A7L6BRW2|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHBSTW-01013|TrEMBL
MSKQSQHVLVTLPHPLLRLASLGLVAFIFTLFSLELSRFGAQLAPLWFPTSIMMVAFYRH
AGKMWPGIALACSLGNIAGSLLFFPGESLSFTYTAINIIEAVVGAMLLRKLLPWYNPLQN
LNDWARLAFGSAVVPPLLGGVLLWLLLPQETSLNTFLIWVLSESIGALALVPLGLLFKPH
YLLRHRNPRLLLETLITLLVTLTFSWLSMMFIPWPFTCVIVLLMWSAVRLPRMEAFLIFL
STVMMVSLMLAADPSLLYTPKQNMMTSIPWLPFLMILLPANMMTMVMYAFRAERKHISES
EARFRNAMEYSAIGMALVGTEGQWLQANKALCQFLGYSQEELRSLTFQQLTWPEDLNNDL
EQLNMLARGEINSYSMEKRYYTRAGEVVWALLAVSLVRHSDTTPLYFIAQIEDINDLKHT
EWMNKRLMERITLANEAGGIGIWEWELQPDVISWDKRMFDLYEVPAHIKPSWQVWYECVV
PEDREHAENVIRDSLAARAPFKLEFRIAVKGGIRHIRSLANRVLNKDGEVERLLGINMDM
TEVKQLNEALFQEKERLHITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQENAIGIPL
LTVLRITFGDNGPLMENIYSADMSRKAMEQEVVLHCRNGNSYDIQYSITPLSTLDGGSIG
SVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQSHVLVFID
LDRFKAVNDSAGHAAGDALLRELSSLMLSMLRSSDMLARLGGDEFGLLLPDCNIESARFI
SGRIISAINDYHFMWDGRLHRIGASAGITLIDDKNHVATDVMSQADIACYAAKNSGRGRV
CVYEPQQSQAHAARSQLSLDEQKHTIMHSPMLMIARGVASPRIPETFSFWLISLRLGTAE
GEVIEEQTFRTGLVDPTLNQALDRRVFSEFFQNAAPAVASKGLSVALPLSAAGLLNSELV
DELLEQLQHSPLPPRLLHLTVPASVIKTNPTQAISALHRLRQFGCRIVLSQVGRDLELFD
NLKYRIVDYLLLDSELSASAHGDLIDEMWVSIIQGHAQRLDIKSIAGPVQLPLIMDALSG
IGIDMIYGDIIANAQPLDLLLNTSNFAIN
>A0A395L1V5|diguanylate cyclase|EC 2.7.7.65|Ensifer sp. M14|TrEMBL
MSVSPSRAGADAPVKDAVRFSRDQLSLILAALPDPAFILTRSGRYAALFGGADHRYYHDG
SSLVGQSVYDVLAHDKAHWFAQEIEKALGSRALHIVEYSLAGSDVKGLEDAGPDHPIWFE
GRVQALDFPVDGEDAVVWVASNITEKNAIEHQLRQQSETDPLTGLNNRRKLLDVLAIEFD
LATRTRQPTCLLMFDVDNFKAVNDELGHSVGDELLATIATVCRRTLRSDDVLARLGGDEF
VVLMPGTTSGEGGLVANGLRQQISLELQSKLALSSTISGGLTEISRSDTSIGDILRRADD
GLYQSKRNGRNQITIV
>A0A1S9D4F1|diguanylate cyclase|EC 2.7.7.65|Chromatiales bacterium USCg_Taylor|TrEMBL
MFRVSLRYGIPLLIVVFTADLAAYTVHKEWGAAEAVVRGEAVSQIISRMTLLQEQLSYSY
ATGDRERIAQEMSLLGSAPEPQIAILANDNAIVLGATKGEWVGRSLAEAARAQWPRWPGE
PLQAIIDRVRAQLSGELFLAAGGRYVLGVYPVKLDARADALPPKRVGVLVVQRDLLHELA
HARRTVEKHRLEMAGVLVGLAVVLGVLIHLLVTRRLNALSIATQKFSGGNLEARAGLRGR
DEVAVLGRAFNRMAEQVADSQKQLERRVQERTAELDRTVSDLQKEIAERRRAEAALFEEK
GRIEVTLASIGDAVITTDVAGQVDYLNRSAKQLTGWSKDEAAGRNLRQVFHIIDESSRDP
IEDPVQRCFQDDGKIVGLANTTLLICRDGRELSLDYSASPIHDHAGTTIGAVLIFRDVTE
ARRAERQLNYHASHDALTGLVNRREFERRLERILATAAQGEEHGVIYLDLDQFKVVNDTC
GHVAGDELLRQVGAVLATQLRKRDTLARLGGDEFGVLLEHCEQGQALRIAHLMREALQDF
RFVWQERGFAVGASFGLVPIGPLTHTLASVFRAADVACYAAKEQGRNRVHLYYPDDHDLA
QHGCRAFRRHWPTADSRSTTSRSLRLAGVVGPTARCSCVFLTATAI
>A0A377LXV6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MTTPRAEYQLYDTRLNMIASSEASTSEANHFDERETAQIAHAIENNTGGGIRLGSRFVSW
ERLDHFDGVILRVHTLHEGVKGDFGSISIVLALLWALFTAMLLISWLVIRRMVSNMYTLQ
HSLQWQAWHDPLTRLHNRGALFERAKALAAQCQAQSLPFSVVQIDLDNFKSINDRFGHQA
GDKVLSHAAGLIASALRKNDVAGRVGGEEFCVVLPGIGLEEARAVAERIRSRIDSKEILV
KRARRCVSARRWGSAARRRRGITTSNNCSR
>A0A157KYJ3|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MRIATITNWAYGATVCLTIASGIIMLMASSADTAERQAVEQRQRFDALTEDIETDAWAQS
DLARLYVIKKDPQTLKEYSQSENNLKSVELRLEKLRDNGASDDELSLLREGIKIIDELQD
EQQTALTSAAQGEDAQAVALLYGAPYEQELERAQNQIDHFRQILDKRVIASVQEATKKSK
ALRTASELMVGLTALLFLFVLGFILKRRVLRPVVRLSDVVHRLASQDYAVETPNFNQIDE
IGDMAQAISIFRENGLARQRLERERDADWAIRELLARMTQRLQGCENFNDVINVAELFAP
NIAPGIAGRLYILDRDPWQMRGVAQWLSPIGEETTFHPDECWAVRRGQSHPPVNGEPDIA
CYHLPASQAESSLCVPLIAQGEAIGLLSFQNITADNAPSRAYLELMAEALGLALANQRLR
DALLEKALFDPLTGLRNRHHLEDTLQTQTAQAMRTGVPLSCMMIDIDHFKSINDRFGHEA
GDLVIKSVASIVQRAAHDNGLAFRYGGEEFLVLLSGADEAGAYACAQKIYNGVHELSLRY
GLTEIGPVDVSIGIASYPQHAQTDNLLRAADVALYRAKELGRARIVSFGMLEAG
>A0A1W6KF53|diguanylate cyclase|EC 2.7.7.65|Marinobacter salarius|TrEMBL
MDSYKEPLKALARPYRKAVLKALLVLTMLGGALFAMLNLLTGSYPLAIVELAMGAYAILV
YRAVRNTQHLERWIIAYAIPFFTAMMFAMTIPRASATVHAWVLLIPIVSHLLMGRRLGLA
ISVFYMSVAGIIFLLRYHDEPAMMQALPVANIAVISLCILVFSHVYEVTREQSQRQLLKI
AQTDTLTGLANRARLSDIFKREQQRSRRYNTPMTLLALDLDHFKEVNDRYGHDTGDLALQ
HVARIFRECLRATDLAARLGGEEFGILLTNTNGQQGLEVAEKIRIAVASTPLTVNNDVIR
LTLSGGVAEFGPDGETLRQLVREADKRLYEAKDRGRNLIIPAETTASLLEPLESDTHRA
>A0A7Z1AGM0|diguanylate cyclase|EC 2.7.7.65|Candidatus Thiodiazotropha endolucinida|TrEMBL
MQGKGSTEALQTGVFSRSDLVQLQEVIDACDVGLCLINNDRRVVAWNRHLSDITGKTDQE
ALSEPLEALIPQLAGPRFFKMVLTAAQLPQSDRSLQTYFSLSGSRHLFRIDENCFIRVSV
KPLMMHPGYCLVQISEIDSTLVQRDKLTTNTMAEQRTRAMLSSVEDAVILLDASGGVEFA
NLAAEGMTGYSNRQMTGRRLTEVYRVFDESDMEKKPLPFEKIVDNEGCQLVLMHREGLSL
PVQQSITSLKDEAGNLESIVLVFKDTSQSRKLAAQLSWQSSHDPVTRLYNRTEFDRQLTA
LLEQSGIEDCVHCLLYLDIDRFKIVNDNCGHAAGDELLRQLASLIKRSIRNSDLLARLGG
DEFGILLSQCSIDAAERIADSIRLSIQGFRFVYGDKSFSQSVSIGMVPIDNQSNNLEQIL
SLADSACFSAKEEGRNQIHIYDPLGSSAARRHGEAKWVTHIRSALDEDRFTLYVQPIKSI
NNKAAEHVEVLIRMLDESGELILPGAFIPAAERFGLMPNVDRWVIDRLIRYMVDNREVCL
AAGRRFFINLSGHSLCDENVLQMILDRIKSYDIPKGMLCFEVTETAAISNLTSAEHFMRT
LQRFGCEFALDDFGSGLSSFSYLKHLPVEYLKIDGAFVKEMLDNLIDDSMVDAINRIGHI
MGLETIAEFVENDSVLHRLKDIGIDYAQGYGICRPYPIEKLFE
>A0A2T4Y2R6|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQRDTFVVRRSFFQWLQKRSNPGLIVNSCFIVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASSLDRQLQFGVDKALFFRNSMRDALQKPLAFDVLHQAVDRFDLLRNRPVWQLAVDK
ERTLPINGVSDAFVEKTVLLNRDDERIRNEISAALEVGYLLRLASSTVQNEERIIYISRA
GFYLSTDTPAQSDDIITRYYHLVTQPWFTQQSERNNRARAVRWFISTASSWTGNERMITA
SIPIYFEHYWYGVVAMDFSFSTMKRLLADATDDHAEGEYQLYDSRLNLIASSESPASLMN
RFDEREMAQIAHAIESDTEGGVRLGSRFISWERLDHFDGVVLRVHTLHEGVQGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYALQSSLQWQAWHDPLTRLNNRGALFERARILA
QQCQQQSLPFSVIQIDLDHFKSINDRFGHQAGDKVLSHAAGIIASGLRENDVAGRVGGEE
FCVVLPGVALPEASVVAERIRARIDSKEILVKKSTTLHITASFGVSCAHEKGNYNFEQLQ
SIADTRLYLAKQGGRNQVIWRDDDKK
>A0A4Q4A1W4|diguanylate cyclase|EC 2.7.7.65|Enterobacter cloacae|TrEMBL
MQHDTFVEKQSLLQWLHKRSNPGLIVNLCFIVVLIFSTLLTWREVVVLEEAYISSQRNHL
ETVASALDRELQFSVNKMLYFRHSMLDALETPLAFGVLQEAVKRFERVRRSPVWQIAVDP
KRTLPINGVSDAFVEQTTLLNRDDDYLDKEISAALEVGYLLRLASTNSRHEERILYVSRA
GFFLETDTPPHHSDIAQRYYHLVTQPWFTQQTDRENRARAVRWFISPPSAFAGKKPLITA
SVPVYYDHVWYGVVAMDFTFATMRQLLVEAMDDHTEGEYQLYDSRLNMLATTEKPADEVN
HFNELELAQIAHAIEQDTEGGIRLGSRFISWARLDHFDGLVLRVHTLDEGVRGDFGSISI
VLALLWALFTAMLLISWLVIRRMVSNMYSMQNSLQWQAWHDPLTRLNNRGALFEQAKRLA
KQCEEQSLPFSVIQIDLDCFKSINDRYGHQAGDKVLTHAAGLIASTLRANDIAGRVGGEE
FCVVLPGLTIEEAAVVAEQIRERINSKEILIKKSTTLRVSASFGVSCALEKGDYHFENLQ
SAADARLYEAKQRGRNRVVWQAHDKK
>A0A381ETA6|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MPHSASKQDDSKLLLDNLVELTSQREQEMLESSLLSTLVELMRVDKAELFACRWVNGAPY
IRRRLEAQASSGKPVVRETNTDGWLPPPAFLYDLLNRVGRDDVVQRIPSGLCLPLRCMGN
IIALVVIHCGSDSRINRDMLKAMTRIHENFLRLLFEADRDMLTALHNRRKFDLRFYNLIA
ALQHEPASTTPHVLALLDIDHFKRVNDQFGHMVGDEVLLLMAQLMQQSFREEDGLFRYGG
EEFALLLQGNQPEIAEQALERFRSTVEGHIFPQVGNITISIGHTRIVHGQLPDRLIEQAD
RALYYAKSHGRNQVRGYEQLEAGGELEAPPASSQVDYF
>A0A8J7S192|diguanylate cyclase|EC 2.7.7.65|Marivibrio halodurans|TrEMBL
MKPMQNIDTFLSIDRISRRALWRVYLVAFLILFAVITGSHLLAEVAAMKQEQHARIINLA
GKQRMLSQRIAGHIEVAARAHTPRLAVIGDILSDINKMEDSHLRLTGQTADTVDPTLSDQ
VRRLYFTAEPSVDDRVTGFLAEARDLIAMIGSGAPVDRDRLAGFVGSARGRLLHALDGVV
NRYQADAEALLNQLRLVNIALYIVALMVLLVELLVVFRPLAKRLDRAQSDLANLAQTDPL
TGSWNRRALMQGGETLWALGLRKDRPFSVVIADIDHFKRVNDTHGHATGDAVIRFFAETC
LAAIRDHDVLGRYGGEEFVILLPDTAIDEAAAVAERLRASLSAAPAEVADGARTVTLSIT
ASLGVASRTAREHTLHALIERADEALYAAKSGGRDRVRRAEAA
>A0A8I1Z699|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MFAIGLFGACAAAAWAGWEARRRGRYLRWFEQYPDAVLVVGKTGRILCANQRAAELAGGD
ASRLANSPLSQWLPAGDPLATPAWKALFAAEGSQACGSLGLHVWRGVDGEACEWLITARA
LSEDRAVLLSLRRPQELYPDQPKYYLAEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHD
IFGTDSATFDATEDAYFQRVHPDDRARVRRELDRHVLGDRPFDVEYRIVRPDGQVRELLE
RNHIQRQASGQVDHLWGTVIDMTEHKQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNP
ALARMGGLTMADPSQLSGLFMAPGVEARLEREALRELLDASGAWQGELLLARRGAAPLPV
LASATRLRDEDGRLLSVWVVSDISGMKESERRLHALAFFDGLTGLANRALFGERLRWHLQ
NEPAGGRLAILFLDLNGFKQVNDLLGHEAGDQVLREVARRLQAGCRPGELAARWGGDEFA
VLLPGVADDEALAARLRELREAASAERWGGGRWLRVSASLGAAVYPESAEDAERLIQLAD
RAMYRAKSEGGGQVWLHDGGGLRTLAGADCGA
>A0A381EYU1|diguanylate cyclase|EC 2.7.7.65|Chromobacterium violaceum|TrEMBL
MTTQNPIEVARETLKQLSTRKLLPTPENFERVYHELTQTPMGRDNKLAVLLLRALETLPQ
DNVQAKVTLTRLRQVLDENRWEQAPQLIIDFLRGIFSAQQLAQSWGQLIQNLIKSWDLRQ
PDLPQHHKQSTLERVLINFGNQPEELNQKLVALLQNWNASPSSRDLPPPEPLPALDGADE
AASDASGSWLAWQRTLAFALKHGLEPRLSDYPDLVDGLESLLQELEGIADDPSLNVFMPK
LRAFMIKLELQSQQEGRLATGLANLLKLMLDNVAELNRSDEYLLGQVGSLQEILSHEPLS
MQQIYQLETSLKEVIRKQGMLKSSLDEAASSLRALLDRFVSRLALMTDSTDEFHGKIQAH
SEKLKQMPNVDELGGIIGSLMEDTSIMQLDLTRSRDELVSAKEQVEAAEHRIRELETALE
AASAKVKEDQLTGAYNRRGLAEYFQREIGRAERTAAPLSIALIDVDNFKQLNDRYGHLAG
DDALKYLVDTIKHSLRPADIVARFGGEEFVILMPDTPETEAVQTVQRLQRELTKTFFLAN
NDKLLITFSAGVARWHLGEQESDVLERADHAMYQAKINGKNRVCSAEDMPG
>A0A6N3D0M0|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MLKVESKYTKKYLFAILFFIIMSIICVTIFLTNINSGINEKVQEILLNEVISHRKSLEAT
ISIQYQELEGISEYITSLNTRDMSQLINFTKAFVSKNGFDRIVVAFEDGIGYLSDGSSYD
ISTRGYYQDTMNGGARNSEPVDSVIDGERRMALSVPIYSQHGQVIGMVMGSYDVRAISEI
EFSNLYNNKGYTYLIDYSGNFLINDQKLHNYQGNFYDYCQESNILSNQQLQQIKTDISNY
VSGCVLTKGGKETRYLVYVPLESSEWVICYSVLVSDAFQDYQFIMKYETYLLGAVAMVLT
VTVLYIFIVNKKERRVLLKRADYDSLTGLYNRRKLTEEIKRYLKAQSEFGLAILDIDDFK
KINDTYGHPIGDIILKEIGQILRDNLGEYLVGRLGGDEFVILIENVQIINIVIQKLELTC
NQIAKIKIEEHPDIVVTCSCGLAVAPKDGETVAELYKAADSALYIAKSLGKNKLAKF
>A0A6N2XY47|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MRLKRLGLPAFLLTLILLCSISVHTLYKIRDYGTLINYVGIVRGASQRLVKLELTDQPND
ELKDYIDEILTELDMGVGKYSLINLDDEDYRTDLNKLKNIWEAIQMDIVLVREGNGHEKL
LSDSEDLFEIANDTVFAVDYYTTTQSNYLLMMLMILSGISLVTWSIIIIFYLRSMITLQR
KNNTLSIVAYRDNLTGVNNRLKFVLEARNIIKKTKGQFAFLYIDIEHFKYINDVFGYQFG
DKILKKYAAVLANSIDKNETFARNNADSFIILRHYESKEMLKQKQIEIDQILIDYVKKAK
NGYQIRLCCGICCYEDVIENLLSMSTLIVLFLLKIL
>A0A6N2ZJJ1|diguanylate cyclase|EC 2.7.7.65|Erysipelatoclostridium ramosum|TrEMBL
MENLLIDNMLENAKIGIWVIELSHNKKNDPKMFGNTHMKLLLGVADSYSPEEVYQFWVER
IHPAYVSYVEEAVERLISGNKAEVEYPWKHPENGWMYIRCGGYLNTNFTQCYRLEGYHQD
ISNLIFRFEPFSFDYQIQDQLLFKEYSRYYMDIYDELCEIDPVTNTMEIVFQRKDKYLSI
FSGINFFEFIKKYIYSMDHLIICETYNELSSAKKQKVTIDVRIHNSNDGYSWIRLVFVLA
QMNYSPKVLMGIMDIQEQKRNMEFFIDSDAILSTIIEENAYIFDIDIMTQNISAIKGENL
SIHDMSYNKFLSLFMQRCSDISELEYLNSFLSFNHLKELVFQKKNAHIDIREKTEHFLYG
WYRIHLMVPKALEDRILILIKKIDKDDVFQTVITKYVQKNFESLCYIDCDSGKYLQFVTE
GMKELIFNENEFDYKDALDTFIESQVVIEDRKVAQTKMNLDYIFLTLQKDGDYFCNIRIL
DSCGEFHQKTIHYYIYDEDTKIILMMVADTTEQYLLNQSEKEQIERLKLKANTDELTGLY
NRYYCKTHINEYLQEVPQGQQAVFLLIDLDNFKNLNDSLGHLAGDQALVDVANVLKNSFC
DDAIISRFGGDEFVGRDMNTLYLKADKALYQAKEDGKNRYKYYNN
>A0A1Y0HMB9|diguanylate cyclase|EC 2.7.7.65|Sulfurospirillum sp. SL2-1|TrEMBL
MATTINEIIKDTLELIKAEHLNLTPDNYSKIFCKVAKQKGVIVEDCQKVDKYTKKLDPNI
ATDMKRFSISNVDELLAFLVAKLNRANEGDALKMVNTLAILTKRVLQAITLLHDAKATSL
ANASLERLDFHQNLQSIELVKEKWFDFISNYDDSYLKKLDSFGHVNKDDLEAMVRDLIKI
MSKDTSTELYGALVPLIIASLAPSIASGMNDELASIGNELRSSPDALGTPALQKELKGLI
SKRIELDKAEVQKKVSALDKILDDINKKIFELIQSSNVSHEQVKVIKADLQSINFEHDSF
ENVHVKLLNIASSLESETKSLSEKMTSNQETITKLQNRVSKLESALLVAKQEVKEDYLTH
VATKRALANELGRVEDAFMRYKVDYTICFIDIDHFKMVNDTYGHEAGDVILSTLGKILRK
YVRQVDFVGRYGGEEFLVILPSIDLAQAIHFADKIRAIVEQFKFLYKNERINVTVSCGVA
QRSLEKSKEETIGSADSFLYKAKEAGRNQVLPVL
>A0A086ZP06|diguanylate cyclase|EC 2.7.7.65|Bifidobacterium boum|TrEMBL
MLNTSSHQSTARTILVVEDEPDLATAIAQRITANGWTARVASDGASAVRAAKQLKPDLVI
MDVMLPVMDGIEATKRIIAERPVPVLMLTARDAESDKVMGLGAGADDYMTKPFSPRELIA
RCEALLRRVERATIIAKNMENEKVLDFGSLVIDPRQRIVTLNGEQVHLTPTEFDLLATLA
RKPKTVFKREKLLEEVWDWPDASGTRTVDSHVKALRHKLGSQMIRTAHGVGYAFEPPESD
DDTATESETR
>A0A653L0V7|diguanylate cyclase|EC 2.7.7.65|Acinetobacter sp. 8I-beige|TrEMBL
MGSLLLICHFAFRAPSYLLWLGLGYIVPSFSVAAQSFMSNKQLALSAPILGSMYLFGAWA
SAYAMGLRKNANARPYWCLALVVMALFSLSYYSYVDDQLWIRMLILNISIALVESLVLFS
MFKHYQGIDLLNKIVDFSYLFIVLYTFVRGIIIFLFLRNIEADMLANSVWWLMMLAASII
LSMWFAIVLLGTLVRDIIHQLNDERLRDPLTHLFNRRGFNEAAKRKLHQLSKQSYFLLMC
DIDHFKKINDTYGHLVGDQILQQVGQIIGQNVRDHDLVGRFGGEEFIVLLQIDDPTLAYN
IANRIRLGIADAGLSSKSIAVTASFGLAAVHQPNLKYAIHTADQLLYQAKHSGRNQIGFE
PAQSILDVSH
>A0A7W5SEH7|diguanylate cyclase|EC 2.7.7.65|Rhizobium sp. BK602|TrEMBL
MTARILVVDDIPANVKLLEARLLAEYFEVLTAEDGLKALAVCESTQVDLVLLDIMMPGMD
GFDVCERLKSDPRTSHIPVVMVTALDQPADRVRGLKAGADDFLTKPVNDLQLISRVKSLL
RLKTLSDELRMRNETARNFGIEDLLRMGDGRADESGHILLVDGRANSQERIVRALKPIAE
VTATSDPQAALFEAAERPFELVIVNSNFDDYDPLRLCSQLRSLERTRFLPVLLVTEQGAD
EMIVRALDLGVNDYIVRPLDPNELVARSLTQIRRKRYNDRLRASVQQTIELAVTDALTGL
NNRRYLDNHLKILFDRSLARGRPLSILITDIDRFKLVNDTYGHDAGDEVLKEFASRIRST
VRGADLACRYGGEEFVVVMPDTSPEIAAAVAERLRAAVETVPVTLRETGAALTITASFGI
SSRLETVETPEQLMKQADRALYEAKKAGRNRVVAAAA
>A0A7V8TEV6|diguanylate cyclase|EC 2.7.7.65|Pectobacterium carotovorum|TrEMBL
MSASPPTFLTVDVRRSGLRFSLRVYIPRIVGTILCALFISSVLITRPVPTLLWVLLLLNT
FIWPHIAYTLSLRSRDPMQCEKRNLLIDVAFGGIWIGFMGVNLLPSAVIAAMVGMNCTAG
GGVKLLIQGIVLQCVACVLVLVLFSVPVSLDTTPLQLYACLPMLLVYPIFLGYVTYTTAL
KLAEHKRMLMEVSIHDGMTSLYNRHHWERLLKHEYDSCQRYKRTATLVLFDIDHFKAFND
NFGHNVGDQAILLLARELTSGFRETDVIGRFGGDEFAVILPQTSAGEALDAVNRIRESLS
LKFLNQTPQLAVFVSVGIAEISPEMGQYIDWLKTADMALYRAKNKGRRRTEVA
>A0A8F2ZVB7|diguanylate cyclase|EC 2.7.7.65|Salmonella enterica subsp. enterica serovar Bovismorbificans str. Sal610|TrEMBL
MFPKIMNDENFYRKAVEQAVAPPDPPDDRQRSGLRFARRIRLPRAVGLGGMFLPVAAVLV
TQPVFGGWWLLLVGWSFVWPHLAWQWAAKALDPLRQEIYNLKVDAILSGMWIALMGVNML
PAAALFMMMSMNLMGAGGRRLFTVGMGLLLASCLVTLQLTGLPVAMRSSSLEVTLSLPVI
MLYPLLFAWVSYQTAIKLAEHKRRLQAMSSRDGMTGVYNRRHWEILLRNEFDHSRRHHRE
ATLLIIDIDHFKSINDTWGHDVGDEAIIALTRQLQITLRGSDIIGRFGGDEFAVIMCGTP
ADSAITAMSRVHERLNTLRLPGAPQVMLRISVGVAPLTPQIGHYREWLKSADMALYKAKN
AGRNRTEVAA
>A0A1V4IMX0|diguanylate cyclase|EC 2.7.7.65|Clostridium oryzae|TrEMBL
MMTKAFDIIEKNLMKVNVLDGTRKIQDVFHEEGIECFTVYEEDRLTGVITKNELIGAHPN
RIVADIMSNKYICADHDIPVWKIEEIFNLNEDVDVILIEKEHEVVGYITRTILNIELGKH
IDLLTGLYKSDYMFYNTYNFIKHRKHATIIFIDLNNFGYINKKYGHIAGDTILKSVADIL
KNNLKQNSYLCRYAGDEFAIVASYCIEDSKILAENIIKAIKSYPFLNDIPVSVSIGITGC
KIQNNKLRSISTLINKLVNVASLASTRAKKDISNLVIVEDVEIDEIA
>A0A1R1INN5|diguanylate cyclase|EC 2.7.7.65|Brevundimonas sp. ZS04|TrEMBL
MPNPTSAVAAPSCVPDPSLDPQSLERLRALLNANADAMVAAFYQVLLNDPDAQTFLHHSI
VQERLSPSLRRWLIDLFAPDLDTRDAAFIARQTKIGEVHARIKIPMHLVMAGAAVLKARL
ADDLAGDAAAFDLLRLAGQRIDHALRLMSQSYEKGASNRARLDEAYRLFSLDQDIHFERE
SQRASLMEWSQKTLFRILASGGVDGAGALGASPFGLWIRHRADFLFDGSPHLTRLNATME
RIDTELLPRFTPDAIPADLAAPLKALEAAVEEVAFLLNEMFQGLAGMEGGRDPLTRALNR
RFLSSILSREIGFANANHTPLSVLLLDVDHFKRINDTHGHPVGDEVLRQVAEAVTENVRP
SDFVFRYGGEEFLVVLVETSLHQAATIAERMRLALAAKPIAAAGLPPFSITASIGVAAHR
GHPDENYLIKAADDALYRAKQNGRNRVEQDRRGA
>A0A7W4PV27|diguanylate cyclase|EC 2.7.7.65|Escherichia sp. 0.2392|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATQTLAALGKQGQFSTAEVRDKQQNILASWHYTRKDPGDTFSNFI
SHWLFPAPITQPIRHNGETIGEVRLTARDSSISHFIWFSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRSGINTLMSSSDARKTSALLFLDGDNFKYINDTWGHA
TGDRVLIEVAKRLAEFGGLQHKAYRIGGDEFAMVLYGVQSESEVQRICSALTQIFNRPFD
LHNGHQTTMTLSIGYAMTIEHASAEKLQELADHNMYQAKHQRAEKLVR
>A0A839B902|diguanylate cyclase|EC 2.7.7.65|Escherichia marmotae|TrEMBL
MMGNDNSLNKRPTFKRALRNISMTSVFITMTLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFDDGPAATETLAALGQQGQFSTAEVRDNQQNILASWHYTSKAPGETFSNFI
SHWLFPAPVIQPIRHNGKIIGEVQLTARDNSISHFIWLSLAVLTGCILLASGIAITLTRH
LHNGLVEALKNITDVVHDVRSNRNFSRRVSEERIAEFHRFALDFNSLLDEMEEWQLRLQA
KNAQLLRTALHDPLTGLANRAAFRNCINTLMNDSAARETSALLFLDGDNFKYINDTWGHA
TGDQVLIEIAIRLMEFSGKQHQSYRIGGDEFAMVLSGVLSEYEVQRICADLTQTFHRPFN
LHNGHQASMTLSIGYALTREHDSAEKLQELADRNMYQAKHQRAETRVK
>A0A5P9CMP3|diguanylate cyclase|EC 2.7.7.65|Vibrio aquimaris|TrEMBL
MRFCLILLAVFYAALSHSHGASKDVLVVHSYHQGFFWTDAFQLGLEDVLQDDHLVLRVEY
LDSKRIQDPTYLEQLYQLYKTKLSQEAFTAIVVSDNNALDLMQRLASEVGETPVIFGGIN
HYSPNMHSQLRATGVIEDIDIYSNIALIERIQPEVKKIYVVSDYSVSGELVRLQVTEFLT
VNPEYKRIVEQITPESYQELIDLSKTLDKSSSILFCMYHRDKNGWITEEAQWQELNRTSG
APIYLVHDLGLGKGAVGGFIQSGRTHGQQTANQLLKVLHFNSKKMPNVEMGTPEIKLDYQ
AVKKWDLGIDGEVSTILFNKPIPFTVRYQRELKIFVSVVVFLTLIIMALVYYLSRLKRSE
SIARESQMLIEMVFDQSYHFIGLLDGYGRAVSCNSKLQELLYHQDYSVDQPIWQHQHWET
NSAKLLKHYFDKEDTKQSAQFEAEIWHSEQGAMVLEIALKPLPDNGQGVNYLFEARDITS
RKITETKLFQREANLSHYYDQQPVMMITLDEHNCVQQVNHFSELLLGYEPERLLGHRLVE
FYWHSDAVTPRQVLLQPKQAMCGVWRREIEYRHADGHAIWIRENIRPLVETGHLLIVGED
ITETKHLAEQLEYQARYDLLTGTYNRNQFEAELEKALIEVESYTRTHAMLYLDLDQLKVL
NDTAGHEAGDMAIQFCASMLQEVLPYNAILARMGGDEFAVLLKDCTERDATSVASSIIWA
LSDQHFVWDDIRLNLTCSIGIRLIDHTAESPQMVHAQADTACHAAKEEGRNRFNLYCQDD
EDLRRREQEMECVSFVHDALANNRIELFAQQILALDDNEPLMHFEILIRIRDAEGEYIAP
GIFMPASERYNMAQLLDKQVVTQALDWFEANPEALEHLGMCSINLSGHSIGNQEFISFLL
NKLQFSRVPCSKICLEITETAAMSNMKQAIALFTRFKELGCKIALDDFGSGLSSFGYLKK
LPVDIVKIDGLFVREIDVNDGDRLMVRSINDLAKQMGKKTVAEFVENNRILDMLIDLGVD
YAQGYLIGIPKPLPTLVDELLASDNQK
>A0A2N7RIA8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MALHIPTLLVVSVFVFFLMGLLTLHAWYRESRERPLAYLGSMMLLGALGVVLVSWRDRGV
DFIPIVFGNVVLLLSAAMNWMAMRTLVGRAPSMAGILAGSLVWLTLCLIPAFYDSMSNRV
LVYSLLAFAYGVLTTLELWRSRNSLDVAFMPALVLTVLHTVFYAVRSATDEGLPLTKDLL
GSGEGVPFFSFMLFESMLYVIGIAYVTLAMVKERAELKLKAAAFSDPLTGIGNRRAFMLH
AGRLLSDSKQHTEPAALLLCDLDNFKRLNDTYGHPVGDQALIAFGRIVVESLRKEDVCGR
IGGEEFACLLNDCDEQTALEIAERIRRSFSQLSILEPGLLSVSIGVVTTRESGYDLSRLL
SEADQALYGAKDQGRNRVQTLRSLYLSLTDN
>A0A7L6U5W9|diguanylate cyclase|EC 2.7.7.65|Citrobacter sp. RHB35-C21|TrEMBL
MEQVEPVNDTLLLTEWQALLRQTSPEVHTLLTSLSDEEIRHLVTVFYDYMLSHAESALFL
NTEQVSTRLSGSMFDWLRSVLGSAHEDLSQLLAKQRKIGVVHARIGLPIDLVNRGARKLK
DELYRVLKTKADSTPALLSDAICFSSLAMDTALEAMTVSYSPSFQNSMHTQEQYRLQTIY
DDVNVERERQIRSFTDWENQFIYNIATGMPFGEMVFLANSDFGMWLSHKGKHILGNSNLL
NKMESLIAEIDSRLTTTLSHQHQPTEPERMSLLQDVRQLSAKIHFLLASMFDALVKQENG
KDSLTQLLNRRFIPTIMRREISLALHTRKPFTLAMLDIDYFKQINDNFGHNTGDLTLKNV
AAVIYDHIRSSDYVFRYGGEEFMILLVESDETQASIILETLRMKIAEMRMAASATETFSI
TVSIGIAEYDYHPDYKQLVDKADRALYLAKSNGRDRVEVYQE
>A0A3S9L903|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MHRLLKRQLRRYFPDGLPESEALTAFVKSVNDSYKNFSRDEAILGHSLDISSQELNERND
TLNSLLDALPDTCIWVDEFEVIRDIRLGQQLDGLFSATDKFKSLDDIALLKGQHRFRSHL
LSCRKNNRPELHECQLTLGDEQIFIETRFSPLKNKQVLVVFRDITVRKVVERLKNSALEE
SQRSGKQLQELINGAPIGIMLIDNTFNVIMVNSYASAHLGMASSELLGQRCDTFIEPTFR
EQYLSAIGQCFSCDDSACDSRFDVSMCSPRHSPFEAELAFSTFNHGGRLVLTQAFTDISA
RKQMEKELRRLAQTDPLTGVANRRFFITRGQAAFDGCRQSGQPLSLLAMDLDHFKSINDT
YGHATGDEVLKCFCRTLEAVVGQDALIGRFGGEEFTLLLPGTDKAGAEAIASNILSGVAQ
QQLETAQGNLGFTTSIGVASLDEADSHLEALLNLADARLYRAKHGGRNRYCSGD
>A0A3S9L5F3|diguanylate cyclase|EC 2.7.7.65|Shewanella khirikhana|TrEMBL
MLPAPIPFDEAERLEALRGLNVLDTEAEERFDRLTRLARRLFDVPICLISLVDSDRQWFK
SCIGLSQSETRRDISFCGHAIMQADIFVIEDAHEDPRFADNPLVTGEPHIRFYAGYPLTL
SNGHRVGTLCIIDRMARHFEPEAYRDLEDLGKLVVSELEAVQTATLDPLTGLSNLRGFEL
LAKQCLAKCQRQQQDATLFFLDLDYFKEINDRFGHQEGNSALAAFASLLKEAFREYDVIA
RIGGDEFVALVSHERSMSPAAGILSRLRQNLARHNIDTPIGYQLEFSCGTARFDALVPSS
LERLLKDADIHMYREKQVHHQKHDEQN
>A0A2N7R2E0|diguanylate cyclase|EC 2.7.7.65|Pseudomonas sp. AD21|TrEMBL
MRNKGGKGLSLARRLYTSRTLGLVLGLLCVSAAMYPLEPPLWVWALMLFNGLLWPHLAFQ
WARRSSVPYHAEHRNLLIDAFMGGFWVAAMHFNPLPSATTISMMAMNNVAIGGLRFLAAG
LAAQILGIGVGLVVFAPAFIPQTSPLQLYACLPLLMLYPLALGWICFRQAYTLGLHKREL
LALSRTDSLTGLLNHGAWKDQLEIEFQRCRRQKQGAAIALIDIDHFKSINDTYGHVAGDI
VLRQLSKMLKQNLRAADVAGRYGGDEFCVILPDLPLFNAAQAMEALRERFSTLGYEQNPA
LKVSLSIGLAAYDPAHGDATRWLNDADQALYEAKASGRNRVICNSEDRPKHELLDSV
>A0A2K4ZLV8|diguanylate cyclase|EC 2.7.7.65|Acetatifactor muris|TrEMBL
MNGNSKKTVKGIKIRTMNICMILISFILYIMLILATINASYRYNLMTSAMEDYIACEKNA
DLVKEGSDYLTEQVRLYTVTMDKKYVEEYFREVYTVKRRDSALEEMKALHLGEKAGEYLQ
SALDNSNKLMEEEIYAMKLISVAQESDMSLFPDVVKNVEIKEEDKNLSYDEMIEKARNMV
FGQEYQNKKSVIMNDISFFLNKNIDDTIEKQEDSVQNLKQTMTRQQVLISILFVENILMF
FLIIVLIIKPLKIYIENIEDKERLDISGSYEFKYLALTYNNIYELNAANEAMLNYRAEHD
PLTGIINRGAFENLRQLLKLKQIPIALLIVDVDKFKLINDGYGHEVGDLVLKKVAKILEE
SFRTSDYTARIGGDEFAVILTDILPDMKSVIMKKINDINEELLHPTDGLPEVSLSVGGAF
SPSGFRDELYKNADSALYRTKENGRCGCSFYEGED
>A0A645FXF4|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLDVDHFKSINDRFGHSTGDLVLKNLAKTIKNRIRKTDCLARWGGEEFVILLQGTPVDKA
FILVEELQDSINKMESTGVDMVTASFGVVEYCSGDTVDSLIQSADKLMYEAKTAGRNCIR
SRR
>A0A645FIH6|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MAHTLRLDGQFERRLPTFEIEEFDALGQDFNALLAEIQLRNAELVDRQLRLERANQSLQH
LADHDSLTGMANRARFASLLKQALTEAAVSGSHVGVLYLDNDRFKSINDRFGHAAGDALL
IDVARRIRGAVRESDLVARLGGDEFAVLLAPLRDVGDAQRVADKILLAMTRGLRLADGVD
IELGVSIGIAVFPDHASSDELLLQAADHAMYQAKRLGRGRACTYSPDVRMEP
>A0A645CXG1|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MDDFKKVNDTYGHAVGDEIIIALAELMKKYCSDNHLPARFGGEEFAIILNEQEKDLCYDF
IEKLRKDFELKTSEIINGTVTISCGIATWTPSLTAEELFNKADSAMYQSKATGKNRTTIL
NK
>A0A7I6T2W5|diguanylate cyclase|EC 2.7.7.65|Klebsiella sp. WP7-S18-CRE-02|TrEMBL
MRPVTVSPVASSGWWARLSRRIRPERVVTICFVVVLLTSTLLTWRETIVLEEAYISSQRN
NLKNVANDMDAQLQFNTDRLLFFRNGMASALQIPLAFEVLRTAELEFEHKRGLPDWHISL
NNNRTLPLYGVSDDFVEHTNLLSRDNALLGNEFMATIELGYLLRLSALTHQHLSRFETEM
LYVSRAGFYLTTEQGHEKSITEHYYSLATSPWFIQQSQRDNPNRGVKWRTSFSHDKVPVA
QKVTAAVPLDYDNYWFGVLAIQLSVNEMTQFLMQSVEGEDEGEYQLYDRRMNLIASSEQD
PAKRTVLSQEIQAQLAHAYEHNNEGSLRQLSRYISWEKLRNFDGVLLRIHSLEEGIRGDF
GSISIALTLLWLLFTTMLLISWAVIRRMVRNMSTLQDSLEWRAWHDMLTRLYNRAALFER
AGKALAACQQAGEPMSVIQLDLDHFKSINDRYGHQAGDRVLSHIGRIILNKVRKTDIAGR
VGGEEFCIVLPETSLEQASVIAERIRESIYRREILISRNQTLRVSASLGVCSSEELQRYD
FEHLQSIADSRLYLAKQNGRNQVCTED
>A0A645EL41|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MRTALLFIDVDDFKNINDTYGHLVGDAVLKELAACIKNNVRIANDAVRFGGDEFVIVLEN
VSAEEAYLVAERIRSCAGELEFSGAESAFHITLSIGLIEGAAPLNELLEKADHAMYTSKS
KGKNNTTIFSENSADGAFHMKLN
>A0A0U1HNV9|diguanylate cyclase|EC 2.7.7.65|Yersinia rohdei|TrEMBL
MALSRFRNVVLLRSMFSTKFFRLDLGRLILILAVMSAFVTLANSFYASYRVQRQLLIDNT
LEANRVYATKLASSTEIFLRNAQDQLHYSSVMAAKNFDDKAVLDAETARLKYQTGSFNSV
AVIGADGIVRATSPESLNLSGHSLSSEGAKEALTLRRPLISKPYESAAKNLVINISTPIV
MPDGHYLGYIGGTIYLRKQSILNELLGEHYYRDGSYITVLDSDGNILYHRDASRIGEVLE
PNSLMQAVKTATNGSLVITNSDGESMLAGYAVVEPSGWQIITLRPEASTLKPLDGLMWKG
LGHITPLALLTLLSVWLLSRMIARPLWLLAGSANDMDKPDIANSIKEIPSWYFESTQLKR
ALLIGINLLQKKIGKLKFEAQTDPMTGLYNRRGLATRLESLSQLGEDFAVIALDIDLFKS
INDSYGHDVGDEVIKQLAIQIRDSSRDSDILCRSGGEEFLMLLPGTRPNVAIQVANRLRN
KVETMEIPGIHPITISLGVAYWNGESMPEEALKRADEALYRAKENGRNRVEIA
>D3GXK4|diguanylate cyclase|EC 2.7.7.65|Escherichia coli O44:H18 (strain 042 / EAEC)|TrEMBL
MQHETKMENQSWLKKLARRLGPGHIVNLCFIVVLLFSTLLTWREVVVLEDAYISSQRNHL
ENVANALDKHLQYNVDKLIFLRNGMREALVAPLDFTSLRNAVTEFEQHRDEHAWQIELNR
RRTLPVNGVSDALVSEGNLLSRENESLDNEITAALEVGYLLRLAHNSSSMVEQAMYVSRA
GFYVSTQPTLFTRNVPTRYYGYVTQPWFVGHSQRENRHRAVRWFTSQPEHASNTEPQVTV
SVPVDSDNYWYGVLGMSIPVRTMQQFLRNAIDKNLDGEYQLYDSKLRLLTSSNPDHSTGN
IFDPRELALLAQAMEQDTRGGIRMNSRYVSWERLDHFDGVLVRVHTLSEGVRGDFGSISI
ALTLLWALFTTMLLISWYVIRRMVSNMYVLQSSLQWQAWHDTLTRLYNRGALFEKARPLA
KLCQTHQHPFSVIQVDLDHFKAINDRFGHQAGDRVLSHAAGLISSSLRAQDVAGRVGGEE
FCVILPGASLTQAAEVAERIRLKLNEKEMLIAKSTTIRISASLGVSSSEETGDYDFEQLQ
SLADRRLYLAKQAGRNRVFASDNA
>A0A645CYB3|diguanylate cyclase|EC 2.7.7.65|bioreactor metagenome|TrEMBL
MLNNTQVIYLSIFLMSEFMSSLKAGSDHHLEIDTISEDKNSSLYSVFENIHTGIAIVDIE
GKCLKVNSRLCEMLDYSEPELLETGFKKLIFPEEPEISPTFLDIISREHSGIYGKEICCL
QKKRKTIWVNISTSTAIDHEKRPLYFVFQIEDMTRQKEVEFSLGNSEKKFELIFENAGDG
MAINEPGGKFLKVNRITCEKLGYSREELLQKTATELVSSESADLFVEQARDLYRKGHAVV
QIMAACKDGSTVPVELGMKLIEYEGKPALLSIVRDITERIKAEDETKIRNAAMDSALNPM
VICSLEGCLTYTNPAFQKTWGYSA
>A0A822PL06|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
LPSTAMLMILCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
IVVYPLMFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
KAGRNRTEVAA
>A0A822PRE6|diguanylate cyclase|EC 2.7.7.65|Shigella flexneri 2a|TrEMBL
MMDNDNSLNKRPTFKRALRNISMTSIFITMMLIWLLLSVTSVLTLKQYAQKNLALTAATM
TYSLEAAVVFADGPAATETLAALGQQGHFQLQKYVISSKIFWHPGITPVRIQAILSAIS
>A0A2P2CJC6|diguanylate cyclase|EC 2.7.7.65|metagenome|TrEMBL
MARPFAAVAGIGLLSVFLPPYERPWWVAALAVVSLVPVVLVFMAAQRRAERSWLDPLAAF
LLFPFVALVNDAAGASTGGSASGMTVLLLLPILWLALTGTPRELWIASALSVATLALPIV
VIGPPDYAFGDWRRALIWGAVAVVIAPVLQRIVRDLERQTRRARVANDRVERLFDDAPHG
VALLDTDGTIIRVNISMAVLVGLDPPEMVGHKLSAFETPGEGRIADHVARLVERPGGTLD
DECTFRDSGGNDVIVALSSTVVGDRGMGEVVMVNVVDMSDRRRYLDRLAHLADHDVLTGL
ANRRRFEAELQRHLERCGRHGPTGALLLLDLDNFKQVNDTLGHNAGDQLLITIAGLLRRS
IRSSDLVARLGGDEFAILLTEGGQDAAQRVAGLVVERVRDHAATLDGVGRRVTASVGAVT
FKAASEHSADVLALADMTMYDAKEAGRNQVAVLPEGDERGPRTAARLHWQSRIEAALEED
RFELHLQPIMNIATGRISSAEVLLRLRDQDELVPPSRFVYIAERAGLMPRVDAWVVEHSL
AMLARIRAEHDPAFEFEVNLSGHSIGNPEIEQAITTSLARHGVDPAALILEITETAAVAD
VAMARDFAARMTDLGCAFALDDFGAGFGSFYYLKHLFFDYVKIDGEFVAHVHESQVDRTI
MRSIVGIARDLGKRTVAEFVSAPEILEVCREEGVDFAQGYLIGKPTTYDDFVSQFIRSPI
QSPIQSPMETVPKD
>A0A0C7ADU5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa|TrEMBL
MNRRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYADPNQQLIARSI
SYTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGQTLASWHRESTGPLHLLEQQL
AHWLLSAPTEQPILHDGQKIGSVEVKGSGGSLLRFLLTGFAGMVLCLLLTALGAFYLSRR
LVRGIVGPLDQLAKVAHTVRRERDFEKRVPEAGIAELSQLGEDFNALLDELESWQARLQD
ENASLAHQAHHDSLTSLPNRAFFEGRLSRALRDANEHREQLAVLFIDSDRFKEINDRLGH
AAGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGADALRIADNIIASMQAPI
RLSDGSTVSTSLTIGIALYPEHADTPAALLHDADMAMYIAKRQARGSRRLAELNDPRILQ
EEKEIDSATPEAPPK
>A0A0H3CCZ8|diguanylate cyclase|EC 2.7.7.65|Caulobacter vibrioides (strain NA1000 / CB15N)|TrEMBL
MKISGARTEPFAAIRKRALARAGAQVAAREVSAPDSAAFLGLTEADLTPKVVEALQTLMG
EIEDLRNEVSVLKLRLNEAQGLADMDVLTPVLNRRAFLRELKRVAAFAQRYGSPASVVFF
DLDGFKSVNDRFGHAAGDEALKAVAKRLQANVRESDIVGRMGGDEFAVLLAQADKETALA
KAQSLAEAVRAEPVEFGEWSAPLHISFGVREIEPGADPEAALAEADAAMFLRKRRSA
>A0A0Y0RFK5|diguanylate cyclase|EC 2.7.7.65|Azospirillum brasilense|TrEMBL
MTSLSSVSKSLAAAASAALLSGAQAVYGFMTGDAVAAALGLLAILPCLAAIRWLALTNRT
IHKAIAVIAAAEKGDLQPRILNIQGASPIADMLRTLNRLLDRVESFGKEANAAMQHAAEG
QYYRRIVMTGMVGEFGAYAHQINDGLAAMDGKSREFVESATRIGANIKEVAQSLSASAAQ
LEASSTAMTATAATASEQSFSAASAAEQVSSNVDGVAAATGEVSGAIGEVAQGVSRTADL
ARSSVEKVREADATIRSLLAASDQIGAVVQLINDIASQTNLLALNATIEAARAGEAGKGF
AV
>A0A170Y3L9|diguanylate cyclase|EC 2.7.7.65|Clostridioides difficile|TrEMBL
MRYKKRNIDKSSELSFQSLAKYFITFYIVIILIILSMFCINTIWVMKKDNQDLLSTTSNR
IEDRVGETIKLLNSLSKDNYIIDNSVNGIDKSKELSMYSDEFGYMMICFVDKNIIVWDEE
GGNISLAGRDYMQKLFATKKYQVTDSFAAGADGKTLNYTIASPIIKNGNVDGCVFAAIYF
DEIKDILKQGKGQQQQNFILFGSENQIMNLTSDETAYGEKYMKLSQKTKYLGTNAKKVEK
DMFNNKSGDYWAFENGKLYFMSYKPIKNTNWSLFCKVNFLDIFALNLIPMGAILSVITLV
FIILICMEKSFMKKRMEVIDMLLGSVQELEKRIYQTERPSEVDFKEIIQLTSKGLTDGLT
GVVTRTVFFDQIYNRVEMEENDKLSVISFVDLDDLKCINDLYGHEIGDMVLKNVGYVLRE
YEIKYNGLIGRYGGDEFVMLLSGFTSREEVEDLLDEIAIRLHTEVLTDDGIIQTHCSVGA
VVCSVKDNKDIDNLLKQADEALYYVKRNGKGNYHLV
>A1U3W3|diguanylate cyclase|EC 2.7.7.65|Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)|TrEMBL
MAFNQDANEFHWLMDMLESVEVGLVVLDLDFHVQAWNGFMEHHSGITARQIRDKVLFEVF
PDIPEAWLTRKVDAVAMLNTRAFTSWEQRPYLFKFRNTRPITGTEEYMFQNLTISPITAP
NGEVEKVCLLVYDVTEFASSKRALERANEQLAKLSMTDRLTGLLNRGTWENLVDAEYERF
RRYGQATSLVMFDIDHFKPVNDTYGHLAGDEVIRHTADVTRNNIRQSDSAGRYGGEEFGI
ILPETDAESARVICERIREAIEKSTVSTSAGDIQYTVSMGIAQLTETPENYMQWMQKADE
ALYKAKESGRNKVVVS
>B2RM56|diguanylate cyclase|EC 2.7.7.65|Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)|TrEMBL
MAKARSVKSFWTASYLFSWIMRELLEKLPKENFEILSPYRAGKDVLGEISKKVGLFPDRL
FAKGELEEKEFKRIKREIFGELAEKFKNAFQDEKDDIARKIDTESDQKRKRELEEIKSRY
SNAASKGEDIRKYLENYLSISSITVELSSDCSILEQLNKYLDTQELFNKASTQTEEDYME
MFIEAPNIPFLKAYSQDRAFPSTSEIAVSGWEQNPPKDANGEVDYSKLTSKTGFRNCYKY
LAVIKADGDGFGTYIKELKVDEEKEIKENGEKENELTRFTKSFFEFSVEVANELIQKTKA
IPVYIGGDDLFLFAPVLEGNVEKDVFNLIKEIDDLFIQKEIGEGLSMSYGVSIFYYKSPM
SEAIDIADSMLRKAKEEKEEKEKKKDTVAISIQKHSGQKIEFLLPCKHSTDKCKQETGLY
KKATELIRAFKEDDSMLNSLIYWIEDMYETIFTDEVTLYQERINAVFDNFFDEEIHKENE
VFFDLLKKFIHSMHHSEDPPRKLKDKKKLLHGILRYCQFVTAKKEK
>O87374|diguanylate cyclase|EC 2.7.7.65|Komagataeibacter xylinus|TrEMBL
MSLKHDDRLRALTHQDSDFWADVVDNVLIVAITDVRGVITYVNDRFCEISRYPREELLGA
THRIVNSGYHDASFFRQMYRTIRGGEIWRGNICNRAKDGTLYWVATTIMPKHNSLGAVEG
YVATRFEITELMNTRDRLKSLAATDPLTGLFNRGGFNNVLQTAVEDKSQNITRDIMLVMF
DLDGFKQINDIHGHHAGDVVLKVISNRLLALVHPEDAVCRLGGDEFALILNHTLHKFPLS
LMLEKLLAELEAPIEVGNTMVNVSGSIGVTPIASQESAESLQKNADIALYAAKRAGGHQA
RMFDMTLHQHALERAQILNDAREGVMKDQFELYYQPIMNFSTGKCDQIEALLRWHHPQRG
LLAAESFRDVFLDAALAQVMSPRLVKSFQNDMRMWNTSLDAYPNLTINLSRLDLLNIGFQ
NDLEAEIKRQGGKAADYVLEISESVLAGRRSDRVLQRLQELSELGFQLTLDDFGLATLPI
SVLRTISFTQAKISRKLVKDIETSPQARGVVAHLIGLAHAFGLSVTVSGVETKGQMEVLR
EMGADRIQGFYISPPISAANLVLAEHIIAPDHTEITLQAS
>P73272|diguanylate cyclase|EC 2.7.7.65|Synechocystis sp. (strain PCC 6803 / Kazusa)|TrEMBL
MEAKLPQNEEQRLAVLRQLNILDTPIEERFERITRMVCRSLKVPIAAISIVDESRQWFKS
IQGLNASETPREIAFCAHAILRDELLLVEDATQDERFADNPLVTDEPFIRFYAGYPLNLG
QDIHVGTLCAIDRVPRELSAEEQEILYDLSKMVESELAAIALSEAQIQLIQELDELERVA
MVDSLTRLWNRLGIETLLKREWEYATRKNSPISIVMIDFDNFKQINDQHGHLVGDEVLQG
SARLIISVLRSYDILGRWGGDEFMLILPGSGREQTAVLLERIQATIAQNPVPTSAGPMAI
SLSMGGVSVFTNQGEALQYWVEQADNQLMKVKRLGKGNFQLAE
>Q2GKF8|diguanylate cyclase|EC 2.7.7.65|Anaplasma phagocytophilum (strain HZ)|TrEMBL
MTAKILIVDDLPSNIKLLQAKLTAEYYTVITATSGPEAIRMAEEHQPDLILLDVMMPGMD
GYETCKNMRTNPAIAYIPIVMVTALDNTTSNRVNGLSAGADDFLIKPIDDVALFSRIKSL
TRFKILVDELRLRGKTTKDMSMVDYNIMHYANQISDGKILIIDEDKIRAESINNLLQESF
QETTILSDPTQNINFTNAAKYDLLIIDMHFAGDGLRLCSEFRNSNEESRYTSILLLIDES
EDTNILHKAFDIGISDYIMVPICNNELVARVNLQIKKKRYQNALRSHLKNNAEMSIRDSL
TGCYNRRYFEMHFQNILNESQEKDKPLSVMLLDIDHFKQVNDSLGHQVGDEILQQICKRI
FNSIRISDLLARYGGEEFVIIMPETCIEEATLVADRLRRIIAESPFTTSAGPLNKTLSIG
AANLRSGETAEQLLTRADKLLYVAKKTRNSVVSEKI
>Q3K751|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens (strain Pf0-1)|TrEMBL
MIASRTPTVPGTTGRSELLLILGSLLSVIAIVCIVTFLLIREHANAQESATRGATTIAQL
IDADVLRTVELYDLTLQGLIAAAQRDDLKDVSPQIRHLALFDRSTTARFKGDILLLDKHG
EVIADSSRVDPLPGNFADRDYFLAHAFNRDTGMFISRPFKPRCDCDDADQWRISFSRRIS
SNTGEFLGVAVASMKLDYFDQLFNSLDIGIDSTLNIINNDGILLAQKPYLQSDSIGKSFA
ARPNVVRILRDSSGNGSFNSISSMDHQQRLYTYSRVGNLPLTVIVALSSEEVFGAWRRTA
ILISSATGVLCAGLLWLTWLLARELRLRQRAERELAQLAATDALTGVANRRMLDQSLRHE
WFRAQRSGKPLSLLMIDADHFKAFNDRHGHQAGDQALRELARVITTNVRRPADLVARYGG
EEFSVILAETDSVGAQQIAEHIRAAVEQLSSVNEDQSPMTVSIGISTWTATSEISLEQLL
FAADKALYQAKEGGRNRVVVA
>Q3KFC4|diguanylate cyclase|EC 2.7.7.65|Pseudomonas fluorescens (strain Pf0-1)|TrEMBL
MSLHPVRPKILGFISEDVSAWLVGVLVLLAGGILTGLLAWGTLNQFHSQLRQRFQLLANE
RYSRIEERFQDQEQRLDGLRRFFANSESVSRAEFDGYTHPLLLRTQAYSFALRVSGAERA
AFEQRVRDEGLSTFSVRELNARGELQLASARDEYVVVLYSQTQSRLGSPLGYDLLAQPLR
RSTLERADQLRSLAVSQPMHLVGIEPAYARGVLLVAPVLREGEPRSYGYVMAVISMRQLL
ADGLPDAFHDYLSVRILDLSTTDQHEVLFESTNEPAQSDLSATRLVRMADHDYQVDILPS
EAFMQANHSSVGSVVVLGGLLSLLLSALLYVLVSQRQRALRMVELRTQELHEREQELRGT
HGQLRGVLNAATQVAIIATDLRGVINTFNPGAEQMLGYHSNEVVGHMTLENLHFPRELVA
RAAELSARYGKAIPTCQAMLVEGGEVGGHEAREWTLVRKDGSHLPVNMLATPVLDEQGLW
VGHLAICIDITERKRVHEALAARDVLLKKLSAHVPGGIYQFKMEFDGRFSVIYASDGIRE
IYELEPDVLLLNAEAIFTRIHPQDVSRVRKSIRASADNLSPWREEYRVQLPERGLRWVRG
EATPEELPGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLTTEMARV
ERGGGELSVIMLDIDHFKRINDQYGHAVGDRVLQAVCERIGHRLRRTDVFCRLGGEEFMV
LCPDIDGDHAHMLAEELWHSLRSAPIDVVGVVTASFGIASWRPGEGADALLLRADSGVYA
AKQGGRDRVERHMN
>Q5GVN1|diguanylate cyclase|EC 2.7.7.65|Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)|TrEMBL
MFLRPPSPWLHALSAKLTALFPECWMRLYAGLSRVFPRSFSAKLLAVTFIGIHLPLLLLI
ACLASQSELDGRPLWSVVIVALLATLAGTALTLVALYRLLAPLRIAADALDSYYADQRLP
TLPETGDDELGRLLRGINRSLRGIDAGMRDLKKHALFDPLTEALNRRGCEQAMRDSVAAS
QREGWPFVLFVLDMDNFKQINDRFGHLAGDRVLVRLVDSAYGWLGAQDWVGRWGGDEFLI
GIHASEDDATLKLNQWLSMLEREDAGDAPLHVSAGSAVCEQGLDATELYCRADAAMYRAK
FSGGRRLVRDGHDTPRGHQVT
>Q6ARU5|diguanylate cyclase|EC 2.7.7.65|Desulfotalea psychrophila (strain LSv54 / DSM 12343)|TrEMBL
MKATNYTLIEQLKVTSREIERRKEYLFFTDEDVQVLVSLKEVVSENIEEIVEAFYERVIP
FDEMDGVIGDAETLRRLKNYQRSYIKTLFAGQYDEEYVHSRLRVGVVHKRIGVEPKFYIS
AIHTLLTILREIITKNSSNDCQACVRNLRAVEKIIMFDLSLTFDTYINSLMEETKRSKRE
LEEYAESLEEVISERTKLLKEQARHDGLTKLLNQHAFYSELRRELARAQRRGYCTVLIYF
DLDKFKALNDSEGHRRGDEVLVMVANSMKASLRDNELCARYGGDEFCIILPESTLKEAEK
VCQRLCKELEKSLVGTGVSCSMGIAISDTANSHDADTLVKEADKAMYEAKKVGGFSLKIA
EGF
>Q72MQ6|diguanylate cyclase|EC 2.7.7.65|Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)|TrEMBL
MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELF
FLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTI
IAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEKTKILAFR
DSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFAD
ILRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFT
WGMSIGSIQKLDELIHEADLSMYASKG
>Q7AQ57|diguanylate cyclase|EC 2.7.7.65|Mycobacterium leprae (strain TN)|TrEMBL
MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQRLVDHSPNMTCVHESGRVTYLNPV
GVKWMAAQSPEQIIGHPLIEFVHPDSMPAMMSRIAPLREVGDASQPSEAVLLRLDGTTLE
VEAVSVLTVWEGKPAYQVIFRDLTTQKAAEETLRFQAALVNHVSDAIIATTSTGMVTSWN
PAAEAIYRRSASDVLGMPIGEAVGAPLDPGAIITEGGVLSTTQYASDGMALAVRVSAAVM
ENGFVLVCSDYTALLRVERRFQTVVALLEEGVIVLDGDGYVESVNPAALRILGVSDRSAL
DDPVRRAATLPMYDAQGRLLDHGRGAVREFLRTGTPKTGFIVGIDRPSDGTRVWLSVNSR
SLNPVDPEDATLLISFTDVTAERQASQYLAHQAAHDTLTGLPNRTSILARIDEQRYCGAP
DQLLTAVLFIDLDNFKGINDSLGHDVGDVVLQTAAQRLRAGLRSRDVVGRFGGDEFVALI
LGKITHTELSKVVDRMHAALSEPTYVADAVLHLRASIGVVAIKGDDPRNIGQILRDADTA
MYRAKLSGEGTSYYTDTFNQQPS
>Q8DKD5|diguanylate cyclase|EC 2.7.7.65|Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)|TrEMBL
MEQLSSDLNLQALVQTPLVSIAPGDSFNNILQGLQKNQGAGLVVEEQGQFRGLITQREVI
RALGKGYSPQEITAERIMLPSDYCLSLKDLDDLLGVLGRFRHLGVDALAVVNESQGVEGL
LTRPALRERLRPADLLRIKRVAEVMVCDVATIAAEASLQEAVVLMSERGVTSLVVPEETS
SGVLPRGIVTEKDIFEALHRQGGVLTGTVGSIMSQPVLTVKPDQSLWQVNHLLKEHQVRR
VVVVDDDGQMVGIVTQSNLLAAIDITEAQGVIQVLTQELSKATAELHWQLSRQQAITAAI
TESEQRYNTLISHLPVALYRRDRARLWHFNYVSDQIYQLTGYFPQDLPDWRQIVPPPDLT
LAEREIEQAIQQQRAYSTTYRIRHRDGCFRYLSDRGQFDPYSQMLHGVLVDVSDQKRTEE
RLKTSLEREMIVSTIIQDIRQSIRLEEILQRAVNSIQQLLLSDRVLIYRFLGDGSGIVAV
EATTLPQYSILGQVIHDPCFTKETARRFLEGRTLSISDVNQAQLQDCYRELLTRLQVQAN
LVVPLLQGQHLWGLLIAHHCRSPRLWQREELFLLQRIAEPLTVALQQAEMYEALEQANTN
LQEMVYIDSLTDIGNRRCFDELFLKEWRRCQREQKPLSLIMLDIDCFKAYNDHYGHLQGD
EILKQVARILESHLQRAGDLATRFGGEEFALILPDTDQRGAIHIVEKIQGALAEANITHA
KSTVGPKLTASFGIATTIPTLDHTPEMLLHLADQCLYEAKTHGRDRWVARELS
>Q8PPS5|diguanylate cyclase|EC 2.7.7.65|Xanthomonas axonopodis pv. citri (strain 306)|TrEMBL
MLVASPLPGATYSDQTPPVDHVMTVLLPPVPIPVDDALRVDAVRRLGVLDTEAEVEFDDI
AWLAAHVSGAPMAMVSLLDADRQWFKARCGTDLEGTPRSVSFCSHAVMGTELMEVPDAEA
DPRFVNNPLVVAAPGVRSYVGVPLIGREGYAYGTLCTLSTTPRVLDENRKQALIRLARQA
VNKLEARRDRLDAQAQRQTLSMLLEAMPDGVVACGTDGLLREFNHAARQWHGTDPRLLPP
EQWALHFDLYTADGNSLLPTEEIPLLRAWRGEHVRNAELVIRATNQPPRSVLCNADPVVG
EQGTALGAVCVMHDITQLKDASAALAGERARLQALVDASQDVAIMAFDPHGRLELFNPGA
ERLLGYRADEVLGTCPVRFHLPAELERHMATLALSPPSYVKLAAAAAGDVLAEELWTLVR
KDGDLRRVRLCFNIIHDAQQGLAGYLAMAIDVTAELQAQAAAQLAAERFAGAFETAPQGM
AIVSLEGDWRDVNPALCGILGYPREQLLRTTFQQITHPDDLEMDLQLVHDLIDGKRDSYS
LAKRYISQHGAVIWAQLSVSLVRDSSGAPVHFVSQIQDVTERHVAAERLAESEARLRAIS
DATPTLVAQFDAVQRYLFANEAHRHWLGVEPAGLVGRHITEVLGEDLSTAARAALAQVVA
GQRASFEHVLGGSAPRDVEVTLVPETQTATPTQGFFLMAHDVTAHKTLHRLMHERATRDA
LTGLPNRHAWSEALQVAVAQAQQQQRSVAVMFLDLDGFKRINDVYGHRAGDAVLVAFGSC
LQRAAGERYLVARLAGDEFVVLLDGLQDAQAECAAVAERIRTLAAEGATFGDQHLPIQPS
IGMAWQYGAQAEASSLMHAADEAMYAAKRARQPDGHAPRS
>Q9A3B9|diguanylate cyclase|EC 2.7.7.65|Caulobacter vibrioides (strain ATCC 19089 / CB15)|TrEMBL
MKISGARTEPFAAIRKRALARAGAQVAAREVSAPDSAAFLGLTEADLTPKVVEALQTLMG
EIEDLRNEVSVLKLRLNEAQGLADMDVLTPVLNRRAFLRELKRVAAFAQRYGSPASVVFF
DLDGFKSVNDRFGHAAGDEALKAVAKRLQANVRESDIVGRMGGDEFAVLLAQADKETALA
KAQSLAEAVRAEPVEFGEWSAPLHISFGVREIEPGADPEAALAEADAAMFLRKRRSA
>Q9HW69|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MNCRASATLWIRSSCLITAMEHGPLQAGNSDAGQGHGAGRSRGARRSGTGAKKARQYSRS
GETGARADDQTLVGQPAGRPINPRSASWQFVRLGNPQGAGYIAARCHYGTEPMRTDKPPL
KQRALQKLLLRRFGMAAGTYLLGLVLLWLALLSGFYRAAPTTAAASTTLVVACQLAFLWL
FASGRNLRYADPSLTEPQVLVAIAWLTYFLYHVDSLRGTFMVFYVLALLFGVFQLPPRVF
ARCAALAFIAFSGIYLVEALQQRLELPGRAALQVLVMFIVMVWLSLFASYIQAMRQRMRQ
RRYALQAHQDTLRGMMRQLEDLVATDELTGLFNRRHFMRMASRALEDLLPNRQHGLALID
LDHFKRINDRHGHAAGDRVLQTFAAVARSCLRDGDVLARYGGEEFVLLLPHADAEQLESC
CERLRLAFQQAEPVGVTVDTLSLSVGMTLLYADDDLDEALQRADQALYRAKRGGRNRCDA
TWEVTSA
>Q9HXT9|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MHNPHESKTDLGAPLDGAVMVLLVDDQAMIGEAVRRSLASEAGIDFHFCSDPQQAVAVAN
QIKPTVILQDLVMPGVDGLTLLAAYRGNPATRDIPIIVLSTKEEPTVKSAAFAAGANDYL
VKLPDAIELVARIRYHSRSYIALQQRDEAYRALRESQQQLLETNLVLQRLMNSDGLTGLS
NRRHFDEYLEMEWRRSLREQSQLSLLMIDVDYFKSYNDTFGHVAGDEALRQVAGAIREGC
SRSSDLAARYGGEEFAMVLPGTSPGGARLLAEKVRRTVESLQISHDQPRPGSHLTVSIGV
STLVPGGGGQTFRVLIEMADQALYQAKNNGRNQVGLMEQPVPPAPAG
>Q9HYQ2|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MCVTQKDRLDDSRSNLYADQLNRGFRGLRFLPELERDYRRYMLEDSFALKRIALSVGMLV
WLAFIGIDLLILAGPPLWGVLAVRLGVLVLLLVCGCLIMLRRHIQLMVPLSIACVLALGV
GAAAVVGLAHRADPGYPYEGLLLVSFAAYFLAGLRLSQALSCALVVLLAYLGFEWWAGTQ
EPLGNNLLFLLFGNLIGAVGCYLLEFKSREHFLISRLLRVMADHDSLTGLHNRRSFNQHL
DRLWRQAQREQKTLALLLCDVDHFKAYNDRYGHQAGDAVLQRIGAVFEANARRPLDMAVR
LGGEEFALLLYGANEHEARLRAEALRAQVQALRMEHEASDTAREVTLSVGVSCLWPTPGN
DLKRLYDLYEHADRALYEAKAFGRNQVVA
>Q9HZ57|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MAPPKQSNTIDFDAAKQKRGPQPGGNASGPRASNLTELRQQLTLQLQSSLEAERILGLFF
EEVRQLIPLDALGYRHPGSDLRLEFGSSAKHSVSYRLSHDSDYLGELIFRRRQRLGEDEQ
RQLESLLGTLLFPLRNALLYRAAIQTALRDALTGTGNRIAMDQALGRELELARRNLQPLS
VLMLDIDHFKRVNDHYGHAVGDEALKAVAETIKDHLRNVDMVFRFGGEEFLVLLSSTPLQ
AACMVGERLRQAVEELDYRHAGEPLKLSISLGCADLRPGEGSDDLLRRVDEALYEAKRDG
RNRLRCA
>Q9I072|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MLACPLPPDEALRQQALDDMALVDTPAEHYLDALVELARETFGVKTVLISLIDHDRQWFK
ARIGLDAEQTPRDLSFCGHAILASEPLMVTDASRDPRFHDNPLVTGPPFIRFYAGEPLHA
SNGQAIGTLCLIDPSPRLLDLREGRQLNRLSILAEGYLQLRSLTEHTRFLRQEIDREQRK
SLLDPLTQLWNRAGFHALHQHELELARASDQRIGIIYSDIDHFKRINDTLGHRAGDSVLR
EAASRLRAALRPEDLLARFGGEEFVAMVRVRETTELTMIANRIRELMEATPIDCAGTSVP
VTISAGCTLAGSGEEPERALARADAALYDAKRAGRNRVVSV
>Q9I4M8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MARTTLESIQHAIEVNSSLALPIALENLSRLTHLALLTVPFNLIHILVFSLKDFRPDLGH
QLWRQEIMYAHGAMALLFGGIGLLALWLRRQPPKLWRMRLLILLGGAGIIGFGVAIACID
QRITSNITPLLLACFACAMFILIRPAYAVPFYGLAMLAFEVAMDHAQADPQLRLSNQANG
LTAFGLGLLLSLILWHGHVRNLRQQRKLELQRQELEEKNRQLEYLAGHDPLTGLFNRREF
DQLVLMELARIARQPQPLSLLMVDLDHFKYINDRYGHPFGDEVIRHAANLLRGNTRSSDS
VARLGGEEFLLLLPDTAEQQARSLAEKLRERLEGTPLATQDGVLCLTASFGVASLDGGGQ
ASYEQLYSAADQALYRAKSSGRNRVEVIRLASLAESLR
>Q9I594|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MEPSPRTAAAVKSGACLLTSTLIARLLEGWVAPDDARLPEEYAAQVTQPRRCIEMSNFNS
HDRVSLCSQPAARLMLSPITRPHRMPLRTRLLWLFLPLLAASLGGIWLLSESILLSRFDR
EDQQRLQEGATVLHNRLDFELKRHLDIVRTYAWWDASYDFIQRPNETFEQENLDHEMLDD
LGFDFVLFLDDRGHLQLKQWSPPAPDQRVLFGAPSASDQALLEALQQRAIRLGALDFRGR
TDHSLSELLLVDNLPTLLVSVPISNNQGSAPAKGAILAGYFLDRERLANLREQMQADLQP
MPNIATDSTWKPLRSRSGSTHNQALLSPRRFIGEHVQQVSVQYLSSSGEPQLRFDITKKR
LLYIQGEKAINFFLGASLLVALGAFLVGYLALELWVLRRVQRLNREVAEVGRNAHSIRLS
DFGNDELGQLAGEMNQMLERLEHSEARDRAILQSMRDGYFEMDVDGVILTVNPALCQLLG
QTRETLIGHPYYELLGEDDLARARQPFQRAMQSGAGKTFAIPLQRADGSLGYFEATVSLI
HDLQGELRGYRGIVRDVSDQIAYQQQLLEMAYRDPLTGLGNRKAFDEQLGQALLRAGSGG
SELALLYLDLDRFKEVNDRFGHDIGDALLRTVAERVRSTLRQPDKAYRLGGDEFAVLLED
SQENNPQRLAERLLAALVQPIALNGERIDFVTPSIGIALYPRHAGDAEGLVRAADSAMYE
AKRQRNHYCLYQAPA
>Q9KKY5|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)|TrEMBL
MDRIWMDSFAGNQLKEMTEMRFARKQHIVLISSGVATAIFLGFALYYYFNHQPLSSGLLL
LSGIVTLLNMISLNRHRELHTQADLILSLILLTYALALVSNAQHELSHLLWLYPLITTLV
MINPFRLGLVYSAAICLAMTASILFNPAQTGSYPIAQTYFLVSLFTLTIICNTASFFFSK
AINYIHTLYQEGIEELAYLDPLTGLANRWSFETWATEKLKEQQSSNTITALVFLDIDNFK
RINDSYGHDVGDQVLKHFAHRLRNNIRNKDRATNQHDYSIARFAGDEFVLLLYGVRNLRD
LDNILNRICNLFVDRYPETDMLNNLTVSIGAAIYPKDAITLPELTRCADKAMYAAKHGGK
NQYRYYHDAAFPPAVETVLGSQPVEAPNVTPLKKAH
>Q9KPJ7|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)|TrEMBL
MPEFLSEFVRFLFAAGLVLGGGLWLFSGWQRYVQPQQWIQLLHHAPSGMLLVGEDRVLRA
NLAAYLLLGIRLVGRHYLFSAEQSEESQQAFYRALASSAQQKRSVPLLWPVPGNLTQTLE
ISASLLRRWPKKLWLVNVIGFECPSHDIQQERHSLAIARTALDSLSELIFIKSTEGHLIA
TNRAFDQFWQGRIEEGSATFKGIMKGRTSQRCWTVTPDGRSCLLETYQRVLMSPQGENIG
LLGISHDVTDWYNMQRQLREEMEKRRDTEVALAQRDTILQNILESSPDSIGIFNENMVYQ
ACNQPFVEALGIAEVSDLVGKRLQDVIPEHIYARLSDTDSQVLHQGKSLRYIDRIERSDG
EFIWFDVVKSPFRDPASGTNGVLIMARDVSERYLAAEQLEAANQELERLSFLDSLTHVAN
RRRFDEQLHTLWHLHVREGKPLSIILCDVDYFKDYNDAYGHLMGDETLKQIAIAFTQVAN
RHSDCVARYGGEEFGILLPNTPQSGAILVAERIHEKVRGLAIPHDHSKVADRITVSLGIV
TLIPRPEDVPEQMVELADRALYQAKANGRNQTSIYQPNH
>Q9KT38|diguanylate cyclase|EC 2.7.7.65|Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)|TrEMBL
MGVFTIKCAAKNTTYHYSTSMLLNAFSRRVFLWLGWLLISTSSLAATSTTYKVATEADDV
VTRVLFDSIAHHFNLEIEYVNYPSFNDILVAIETGNADFAANITYTDLRAQRFDFSRPTN
IEYTYLYSYGGLRLPELRLVGIPKGTTYGTLLKEHYPYIQQVEYEGHLEALTLLESGRVD
GVVDAINQLKPMLLKGLDVQLLNDQLPIQPVSIVTPKGKHSALLGKIEKYAHSAHVQRLL
RESIQKYQLDIRKQALRQSVVESGLNVQRVLRVKLENNPQYALYQPDGSVRGISADVVFQ
ACEMLLLKCELVSNGQETWESMFDDLQDKSIDILAPITVSQQRKNLAYFSESYYHPQAIL
VKREHYKDDVYSNVSELVAERIGVIKDDFFEELLQQMLPNKILFSYASQEEKVQALLNKE
VDYIVLNRANFNLLLRESTEMLPIVEDTMIGSFYQYDIAIGFAKNPLGATLAPLFSRAIK
MLNTEQIIHTYDYQPNWRATLLAEKKYQRSTQWLFAMAFIVLFMVAFYLHGISHTDNLTK
LRNRRALYNRYRRGLSPRLSLVYLDVNTFKSINDQYGHEVGDKVLKQLAQRIEAVWRGRS
YRIGGDEFILIGECSAKRLEHVVAQCERFMFVDAERDVSFEVSVAIGIAKNRERTESLNE
VMHQADIAMYRAKAESTQSPFQAASKVKGLHIV
>Q9X2A8|diguanylate cyclase|EC 2.7.7.65|Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)|TrEMBL
MKVSGGEVPPFFKEGFFFTSEELTHLINVCSSTSAIISVLKDSKYRRSLVLYLKRPLSKD
ALLLIQTLLTTLEREDLSFGVKELEYMAYHDPLTGLPNRRYFFELGNRYLDLAKREGKKV
FVLFVDLAGFKAINDTYGHLSGDEVLKTVSKRILDRVRRSDVVARYGGDEFTILLYDMKE
EYLKSLLERILSTFREPVRVENKHLSVTPNIGVARFPEDGENLEELLKVADMRMYKAKEM
KVPYFSLS
>S0JAX7|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain PAK)|TrEMBL
MSRDDVQRWKDKYLENIEQQERLQRRWDARIDLLRRGLVRSSLAAEGSDKAVDQCMKELR
EILRRDDMDAGLSGLIPRLEKAVLDSEQRRQQRTQQNIDALGELAQQLLALDLPRELRKP
LKQFARDIEERARQSREIPILLSELSRLQRQALAERKGGDAEDGRPSLLQRLFGGKESET
TAEPSASVPSVVAASNTPIQPAAAAPSLPVAEHDEAPGGPPQPLPARTVAAIESAPAGWV
GVAERGEPNQILLDEPREIWLDSLPLPAGLSFSETLEEAGAEPSPAMPADVESAPEAPAT
PVDNLDGQAVDEAYELPPPIPEPGYSAVAPHIEASLLRLLDGLSLPSSHQPQAEALRERI
DGSLNWYELVPVLDDLAVLVLSLADSGQRDFEEYLRQLNERLESFLGHLGDAHAGYTDVL
DNARGFDQSLREQVSGLQASVQQATDLNSLKLAVDSRLNGLLASMDEHQREQAEHEQEVS
GRLQALMERVNSMEQDAKAFHSHLEDQRQKALTDPLTGLPNRAALSERLEQEVARRHRDG
GDLLLAVLDIDHFKRINDDFGHLAGDKVLKIIAGELRKRLRQADFIARFGGEEFVVLLPA
TSLEAGRQLLERLRAAIAACPFHFKGEPLSITCSAGITAFEGNEAGEAVFERADQALYRA
KRAGRDRLEVA
>Q9HVI8|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MSTPSLTPSPPPAGDPLTVPDRPAAKAGLLLLVLLMLGLLLWQMSQELRQQERFEHERAA
AQLDRLNDRLSLTLELKARTALALLPGVPPSERGEIQGRLLPRISDALPQVRQLQWVDSA
PQTDSPSPETTLPEQLRQHAGSGLYHYCLDPRDGESLYLTLREPGSRRDSGFWLLHLASD
SLAQWSPDLPTGNLLWRLEDQYAGRVLWHTPGSTALLDDMQTLGVEPLRNSDWQLRGLYD
STRVRLGLLPGIGGELAIFLLLVGVTVYMLLRLHREQQGLRAMTLASQRSLRQAATALAA
IDERVLVTRADGRLSYLNPQAERLFGISSAQARQHHLLGLLPDLEPGWLTDAGGDGETRS
ELLPLRVRGEPRTFTLSRHPLASYPALADQAWTLREQILQGGQVWVLRDVTEEQHALGVL
EETRRRYQDIFEGVGVALCVLDLSALRQALVEQGLDSCAALRAWLAGEPGRQQALLERIR
ITEINDVSRRLLQIDSTEQAWQRLLDHGPLQPDSLRLQVIEALIERRPVLELEATLRCGK
STPRHLWLQLRLPENPGEWHAVTLSLSDVTSRKEVELSLIEREKFWSDAVQAVPDTLYIH
DLHARRVIFSNHHLGQQLGYNQEELARMGENFWETLLHPDDQEYYWRIRNLQHVVGDGLL
LDSQLRWRHRDGRWHWFDIREQAFSRDRSGRVARLIGVAKDITFTVEANNALRENGRRYR
MLAENISDVIFSTDAELNASYVSPSVQHVFGYSPEWALLNGLHQTATNPRQLGRLNGLLR
RVRHAIGDRQKLAELRENPGQHLFALDCLRADGRKIPIELRIVLMWDEHDRFEGLLGIAR
DISQQRRAERELRMAATVFEHSTAAIMVTDPAGYIVQVNDSFSRLTGYSPADVLDQQPRL
LTADRQEANQLKHVLASLQHSGSWEGEILQKRKTGELYPSWVGITAVRDEEGDLVSFVCF
FSDISERKASERRIHRLAYYDALTHLPNRTLFQDRLHTALQQAERNGQWVVLMFLDLDRF
KPINDSLGHAAGDRMLQEVATRLSACVSQDDTVARMGGDEFTLLLPSQGDREIALKRAIQ
VAELILGRLARPFTLEGREFFVTASIGVALSPQDGAELSLLMKNADTAMYHAKEMGKNNF
QFYQAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRG
LVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKVRVPKVSVNLSARQFADGQLG
ERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVDDFGTGYSSLN
YLKQFPIDVLKIDRSFVDGLPHGEQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLRE
HGCDEVQGYLFGRPMPAEQFGMLYASDVLFMFNEG
>Q9I4L5|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MNRRRRYTGSNPSLRRVLYRAHLGVALVAVFTAGLAVTLVGLLTLRAYADPNQQLIARSI
SYTVEAAVVFGDAQAAEESLALIASSEEVSSAIVYDRQGQTLASWHRESTGPLHLLEQQL
AHWLLSAPTEQPILHDGQKIGSVEVKGSGGSLLRFLLTGFAGMVLCLLLTALGAFYLSRR
LVRGIVGPLDQLAKVAHTVRRERDFEKRVPEAGIAELSQLGEDFNALLDELESWQARLQD
ENASLAHQAHHDSLTSLPNRAFFEGRLSRALRDANEHREQLAVLFIDSDRFKEINDRLGH
AAGDTVLVNIAMRIRGQLRESDLVARLGGDEFAVLLAPLASGADALRIADNIIASMQAPI
RLSDGSTVSTSLTIGIALYPEHADTPAALLHDADMAMYIAKRQARGSRRLAELNDPRILQ
EEKEIDSATPEAPPK
>F7RW09|diguanylate cyclase|EC 2.7.7.65|Idiomarina sp. A28L|TrEMBL
MSADLGSDDISKLIAACDQEPIHIPNAIQPFGAMLIVEKDTQQIVYASANSAEYFSVADN
TIHELSDIKQANINSLLPEHLISGLASAIRENEPIWVETDRLSFLGWRHENYYIIEVERY
HVQTSNWFEIQFQRAFQKLRNCKTHNDLINTLTRLIQEISGYDRVMIYQFDPEWNGRVIA
ESVRQLFTSMLNHHFPASDIPAQARAMYSINPIRIIPDVNAEPQPLHMIHKPQNTEAVNL
SSGVLRAVSPLHMQYLRNFGVSASTSIGIFNEDELWGIVACHHTKPRAIGRRIRRLLVRT
VEFAAERLWLIHSRNVERYMVTVQAAREQLSTTADDKHSSHEIVIEHAADWCKLFRCDGI
GYLRGEELTTYGETPDQTTINKLVEWLEENGKKSLFWHSHMLKEDAPGLLPDGSRFAGLL
AIPLKSDADLFSYLLLFRVAQNEVRTWAGKPEKLSVETSTGTMLGPRKSFEAWQDEVSGK
SQPWRTAQLYAARDIARDLLIVADSMQLNLLNDQLADANENLEKLASFDDLTGIFNRRRM
EDRLESEVKEAQRYKKQFGILLFDLDKFKSVNDTYGHNIGDQILQNTCAAVSETLRDTDK
FGRWGGEEFLIIAPQTGMPELMQLGERVRAAVEKMQHKDLPAVTISIGVAEFQNDTRWDH
MIDRADKAMYRAKENGRNQVCSQ
>Q9HUK6|diguanylate cyclase|EC 2.7.7.65|Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)|TrEMBL
MAIEKKTIRLLILEDSQNEAERLVSLFRNAGHATRVHRLTSPEDLAETLQQSWDLLIAAP
TSECLEPGEALATLRRQSRDIPFIQLVADNSSDAITDALMLGAQDALPQGEDERLVLVAN
RELAGLAERRARRAAELALREAEKRCQLLLDSSVDAITYVHDGMHIYANRSYMALFGYED
AEELEGLPVIDLIASCDQGAFKDFLKGYQNDQRQTELVCTGVKLDGQEFKARISLSAATY
DGEPCIQVVIRGEVDNAELEEKLREVSSQDPVTGLYNRSHFLDLMDAAVQQAVTARKPST
LAYIHLNGYPSLQADHGLSGIDLLLGQLAGLMREQFGEEADLARFGDSIFAALFKGKTPE
QAQAALQRLLKKVENHLFELNGRSAQATLSIGVAGLDEKTAKAQDVMNRAHRCADDAARK
GGSQIKQYNPAEELAAAAQRGDVIAILQQALETNSFRLLFQPVISLRGDSHENYEVLLRL
LNPQGQEVPPAEFLHAAKEAGLAEKIDRWVILNSIKLLAEHRAKGHQTKLFVHLSSASLQ
DPGLLPWLGVALKAARLPPESLVFQISEADATSYLKQAKQLTQGLATLHCQAAISQFGCS
LNPFNALKHLTVQFIKIDGSFVQDLNQVENQEILKGLIAELHEQQKLSIVPFVESASVLA
TLWQAGATYIQGYYLQGPSQAMDYDFSSGDE