Sequence of VGFR2_MOUSE
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MESKALLAVA LWFCVETRAA SVGLPGDFLH PPKLSTQKDI LTILANTTLQ ITCRGQRDLD
60 WLWPNAQRDS EERVLVTECG GGDSIFCKTL TIPRVVGNDT GAYKCSYRDV DIASTVYVYV
120 RDYRSPFIAS VSDQHGIVYI TENKNKTVVI PCRGSISNLN VSLCARYPEK RFVPDGNRIS
180 WDSEIGFTLP SYMISYAGMV FCEAKINDET YQSIMYIVVV VGYRIYDVIL SPPHEIELSA
240 GEKLVLNCTA RTELNVGLDF TWHSPPSKSH HKKIVNRDVK PFPGTVAKMF LSTLTIESVT
300 KSDQGEYTCV ASSGRMIKRN RTFVRVHTKP FIAFGSGMKS LVEATVGSQV RIPVKYLSYP
360 APDIKWYRNG RPIESNYTMI VGDELTIMEV TERDAGNYTV ILTNPISMEK QSHMVSLVVN
420 VPPQIGEKAL ISPMDSYQYG TMQTLTCTVY ANPPLHHIQW YWQLEEACSY RPGQTSPYAC
480 KEWRHVEDFQ GGNKIEVTKN QYALIEGKNK TVSTLVIQAA NVSALYKCEA INKAGRGERV
540 ISFHVIRGPE ITVQPAAQPT EQESVSLLCT ADRNTFENLT WYKLGSQATS VHMGESLTPV
600 CKNLDALWKL NGTMFSNSTN DILIVAFQNA SLQDQGDYVC SAQDKKTKKR HCLVKQLIIL
660 ERMAPMITGN LENQTTTIGE TIEVTCPASG NPTPHITWFK DNETLVEDSG IVLRDGNRNL
720 TIRRVRKEDG GLYTCQACNV LGCARAETLF IIEGAQEKTN LEVIILVGTA VIAMFFWLLL
780 VIVLRTVKRA NEGELKTGYL SIVMDPDELP LDERCERLPY DASKWEFPRD RLKLGKPLGR
840 GAFGQVIEAD AFGIDKTATC KTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL
900 GACTKPGGPL MVIVEFCKFG NLSTYLRGKR NEFVPYKSKG ARFRQGKDYV GELSVDLKRR
960 LDSITSSQSS ASSGFVEEKS LSDVEEEEAS EELYKDFLTL EHLICYSFQV AKGMEFLASR
1020 KCIHRDLAAR NILLSEKNVV KICDFGLARD IYKDPDYVRK GDARLPLKWM APETIFDRVY
1080 TIQSDVWSFG VLLWEIFSLG ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC
1140 WHEDPNQRPS FSELVEHLGN LLQANAQQDG KDYIVLPMSE TLSMEEDSGL SLPTSPVSCM
1200 EEEEVCDPKF HYDNTAGISH YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI PDDSQTDSGM
1260 VLASEELKTL EDRNKLSPSF GGMMPSKSRE SVASEGSNQT SGYQSGYHSD DTDTTVYSSD
1320 EAGLLKMVDA AVHADSGTTL RSPPV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
500017
Millauer B.,Wizigmann-Voos S.,Schnurch H.,Martinez R.,Mueller N.P.H.,Risau W.,Ullrich A.
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Cell
72
835-846
1993
500018
Mathews W.,Jordan C.T.,Gavin M.,Jenkins N.A.,Copeland N.G.,Lemishcka I.R.
A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
Proc. Natl. Acad. Sci. U.S.A.
88
9026-9030
1991
500019
Oelrichs R.B.,Reid H.H.,Bernard O.,Ziemiecki A.,Wilks A.F.
NYK/FLK-1: a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo.
Oncogene
8
11-18
1993
500020
Albuquerque R.J.,Hayashi T.,Cho W.G.,Kleinman M.E.,Dridi S.,Takeda A.,Baffi J.Z.,Yamada K.,Kaneko H.,Green M.G.,Chappell J.,Wilting J.,Weich H.A.,Yamagami S.,Amano S.,Mizuki N.,Alexander J.S.,Peterson M.L.,Brekken R.A.,Hirashima M.,Capoor S.,Usui T.,Ambati B.K.,Ambati J.
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
Nat. Med.
15
1023-1030
2009
500021
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
500022
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
500023
Patterson C.,Perrella M.A.,Hsieh C.-M.,Yoshizumi M.,Lee M.-E.,Harber E.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
J. Biol. Chem.
270
23111-23118
1995
500024
Quinn T.P.,Peters K.G.,de Vries C.,Ferrara N.,Williams L.T.
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.
Proc. Natl. Acad. Sci. U.S.A.
90
7533-7537
1993
500025
Shalaby F.,Rossant J.,Yamaguchi T.P.,Gertsenstein M.,Wu X.F.,Breitman M.L.,Schuh A.C.
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Nature
376
62-66
1995
500026
Pepper M.S.,Baetens D.,Mandriota S.J.,Di Sanza C.,Oikemus S.,Lane T.F.,Soriano J.V.,Montesano R.,Iruela-Arispe M.L.
Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution.
Dev. Dyn.
218
507-524
2000
500027
Meyer R.D.,Dayanir V.,Majnoun F.,Rahimi N.
The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.
J. Biol. Chem.
277
27081-27087
2002
500028
Dixelius J.,Makinen T.,Wirzenius M.,Karkkainen M.J.,Wernstedt C.,Alitalo K.,Claesson-Welsh L.
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
J. Biol. Chem.
278
40973-40979
2003
500029
Autiero M.,Waltenberger J.,Communi D.,Kranz A.,Moons L.,Lambrechts D.,Kroll J.,Plaisance S.,De Mol M.,Bono F.,Kliche S.,Fellbrich G.,Ballmer-Hofer K.,Maglione D.,Mayr-Beyrle U.,Dewerchin M.,Dombrowski S.,Stanimirovic D.,Van Hummelen P.,Dehio C.,Hicklin D.J.,Persico G.,Herbert J.M.,Communi D.,Shibuya M.,Collen D.,Conway E.M.,Carmeliet P.
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nat. Med.
9
936-943
2003
500030
Holmqvist K.,Cross M.J.,Rolny C.,Haegerkvist R.,Rahimi N.,Matsumoto T.,Claesson-Welsh L.,Welsh M.
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
J. Biol. Chem.
279
22267-22275
2004
500031
Singh A.J.,Meyer R.D.,Band H.,Rahimi N.
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation.
Mol. Biol. Cell
16
2106-2118
2005
500032
Bernatchez P.N.,Acevedo L.,Fernandez-Hernando C.,Murata T.,Chalouni C.,Kim J.,Erdjument-Bromage H.,Shah V.,Gratton J.-P.,McNally E.M.,Tempst P.,Sessa W.C.
Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function.
J. Biol. Chem.
282
30745-30753
2007
500033
Kanemura H.,Satoh T.,Bilasy S.E.,Ueda S.,Hirashima M.,Kataoka T.
Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.
Biochem. Biophys. Res. Commun.
387
754-759
2009
500034
Facemire C.S.,Nixon A.B.,Griffiths R.,Hurwitz H.,Coffman T.M.
Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.
Hypertension
54
652-658
2009
500035
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
500036
Nakao S.,Zandi S.,Hata Y.,Kawahara S.,Arita R.,Schering A.,Sun D.,Melhorn M.I.,Ito Y.,Lara-Castillo N.,Ishibashi T.,Hafezi-Moghadam A.
Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis.
Blood
117
1081-1090
2011
