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Sequence of HTRA2_MOUSE

EC Number:3.4.21.108

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
HtrA2 peptidase
Q9JIY5
Mus musculus
458
49348
Reaction
cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Other sequences found for EC No. 3.4.21.108

General information:

Sequence
show sequence in fasta format
  0 MAALKAGRGA NWSLRAWRAL GGIFWRKPPL LAPDLRALLT SGTPDSQIWM TYGTPSLPAQ
 60 VPEGFLASRA DLTSRTPDLW ARLNVGTSGS SDQEARRSPG SRRREWLAVA VGAGGAVVLL
120 LWGWGRGLST VLAAVPAPPP TSPRSQYNFI ADVVEKTAPA VVYIEILDRH PFSGREVPIS
180 NGSGFVVASD GLIVTNAHVV ADRRRVRVRL PSGDTYEAMV TAVDPVADIA TLRIQTKEPL
240 PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQN NVEYIQTDAA
300 IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS WFGTSGSQRR
360 YIGVMMLTLT PSILIELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEKL
420 AQNAEDVYEA VRTQSQLAVR IRRGSETLTL YVTPEVTE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
45385
Gray C.W.,Ward R.V.,Karran E.H.,Turconi S.,Rowles A.,Viglienghi D.,Southan C.,Barton A.,Fantom K.G.,West A.,Savopoulos J.W.,Hassan N.J.,Clinkenbeard H.,Hanning C.,Amegadzie B.,Davis J.B.,Dingwall C.,Livi G.P.,Creasy C.L.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
Eur. J. Biochem.
267
5699-5710
2000
45387
Verhagen A.M.,Silke J.,Ekert P.G.,Pakusch M.,Kaufmann H.,Connolly L.M.,Day C.L.,Tikoo A.,Burke R.,Wrobel C.,Moritz R.L.,Simpson R.J.,Vaux D.L.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
J. Biol. Chem.
277
445-454
2002
45388
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
45389
Kim J.B.,Kim S.Y.,Kim B.M.,Lee H.,Kim I.,Yun J.,Jo Y.,Oh T.,Jo Y.,Chae H.D.,Shin D.Y.
Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.
J. Biol. Chem.
288
12014-12021
2013