Sequence of HTRA2_HUMAN

HtrA2 peptidase

O43464

458

48841

45364

Faccio L.,Fusco C.,Chen A.,Martinotti S.,Bonventre J.V.,Zervos A.S.

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.

J. Biol. Chem.

275

2581-2588

2000

45365

Gray C.W.,Ward R.V.,Karran E.H.,Turconi S.,Rowles A.,Viglienghi D.,Southan C.,Barton A.,Fantom K.G.,West A.,Savopoulos J.W.,Hassan N.J.,Clinkenbeard H.,Hanning C.,Amegadzie B.,Davis J.B.,Dingwall C.,Livi G.P.,Creasy C.L.

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Eur. J. Biochem.

267

5699-5710

2000

45366

Faccio L.,Fusco C.,Viel A.,Zervos A.S.

Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.

Genomics

68

343-347

2000

45367

Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Nature

434

724-731

2005

45368

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

45369

Suzuki Y.,Imai Y.,Nakayama H.,Takahashi K.,Takio K.,Takahashi R.

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

Mol. Cell

8

613-621

2001

45370

Savopoulos J.W.,Carter P.S.,Turconi S.,Pettman G.R.,Karran E.H.,Gray C.W.,Ward R.V.,Jenkins O.,Creasy C.L.

Expression, purification, and functional analysis of the human serine protease HtrA2.

Protein Expr. Purif.

19

227-234

2000

45371

Bartke T.,Pohl C.,Pyrowolakis G.,Jentsch S.

Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

Mol. Cell

14

801-811

2004

45372

Balakrishnan M.P.,Cilenti L.,Mashak Z.,Popat P.,Alnemri E.S.,Zervos A.S.

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Am. J. Physiol.

297

0-0

2009

45373

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

45374

Kim J.B.,Kim S.Y.,Kim B.M.,Lee H.,Kim I.,Yun J.,Jo Y.,Oh T.,Jo Y.,Chae H.D.,Shin D.Y.

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

J. Biol. Chem.

288

12014-12021

2013

45375

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

45376

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

45377

Li W.,Srinivasula S.M.,Chai J.,Li P.,Wu J.W.,Zhang Z.,Alnemri E.S.,Shi Y.

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.

Nat. Struct. Biol.

9

436-441

2002

45378

Strauss K.M.,Martins L.M.,Plun-Favreau H.,Marx F.P.,Kautzmann S.,Berg D.,Gasser T.,Wszolek Z.,Mueller T.,Bornemann A.,Wolburg H.,Downward J.,Riess O.,Schulz J.B.,Krueger R.

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

Hum. Mol. Genet.

14

2099-2111

2005

45379

Bogaerts V.,Nuytemans K.,Reumers J.,Pals P.,Engelborghs S.,Pickut B.,Corsmit E.,Peeters K.,Schymkowitz J.,De Deyn P.P.,Cras P.,Rousseau F.,Theuns J.,Van Broeckhoven C.

Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.

Hum. Mutat.

29

832-840

2008

45380

Simon-Sanchez J.,Singleton A.B.

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.

Hum. Mol. Genet.

17

1988-1993

2008

45381

Unal Gulsuner H.,Gulsuner S.,Mercan F.N.,Onat O.E.,Walsh T.,Shahin H.,Lee M.K.,Dogu O.,Kansu T.,Topaloglu H.,Elibol B.,Akbostanci C.,King M.C.,Ozcelik T.,Tekinay A.B.

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.

Proc. Natl. Acad. Sci. U.S.A.

111

18285-18290

2014

45382

Mandel H.,Saita S.,Edvardson S.,Jalas C.,Shaag A.,Goldsher D.,Vlodavsky E.,Langer T.,Elpeleg O.

Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.

J. Med. Genet.

53

690-696

2016

45383

Lek M.,Karczewski K.J.,Minikel E.V.,Samocha K.E.,Banks E.,Fennell T.,O'Donnell-Luria A.H.,Ware J.S.,Hill A.J.,Cummings B.B.,Tukiainen T.,Birnbaum D.P.,Kosmicki J.A.,Duncan L.E.,Estrada K.,Zhao F.,Zou J.,Pierce-Hoffman E.,Berghout J.,Cooper D.N.,Deflaux N.,DePristo M.,Do R.,Flannick J.,Fromer M.,Gauthier L.,Goldstein J.,Gupta N.,Howrigan D.,Kiezun A.,Kurki M.I.,Moonshine A.L.,Natarajan P.,Orozco L.,Peloso G.M.,Poplin R.,Rivas M.A.,Ruano-Rubio V.,Rose S.A.,Ruderfer D.M.,Shakir K.,Stenson P.D.,Stevens C.,Thomas B.P.,Tiao G.,Tusie-Luna M.T.,Weisburd B.,Won H.H.,Yu D.,Altshuler D.M.,Ardissino D.,Boehnke M.,Danesh J.,Donnelly S.,Elosua R.,Florez J.C.,Gabriel S.B.,Getz G.,Glatt S.J.,Hultman C.M.,Kathiresan S.,Laakso M.,McCarroll S.,McCarthy M.I.,McGovern D.,McPherson R.,Neale B.M.,Palotie A.,Purcell S.M.,Saleheen D.,Scharf J.M.,Sklar P.,Sullivan P.F.,Tuomilehto J.,Tsuang M.T.,Watkins H.C.,Wilson J.G.,Daly M.J.,MacArthur D.G.

Analysis of protein-coding genetic variation in 60,706 humans.

Nature

536

285-291

2016

45384

Olahova M.,Thompson K.,Hardy S.A.,Barbosa I.A.,Besse A.,Anagnostou M.E.,White K.,Davey T.,Simpson M.A.,Champion M.,Enns G.,Schelley S.,Lightowlers R.N.,Chrzanowska-Lightowlers Z.M.,McFarland R.,Deshpande C.,Bonnen P.E.,Taylor R.W.

Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.

J. Inherit. Metab. Dis.

40

121-130

2017