Sequence of HOIL1_HUMAN
EC Number:2.3.2.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.31
General information:
Sequence
0 MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS PTQDIRLWVS
60 VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ WVIGQRLARD QETLHSHGVR
120 QNGDSAYLYL LSARNTSLNP QELQRERQLR MLEDLGFKDL TLQPRGPLEP GPPKPGVPQE
180 PGRGQPDAVP EPPPVGWQCP GCTFINKPTR PGCEMCCRAR PEAYQVPASY QPDEEERARL
240 AGEEEALRQY QQRKQQQQEG NYLQHVQLDQ RSLVLNTEPA ECPVCYSVLA PGEAVVLREC
300 LHTFCRECLQ GTIRNSQEAE VSCPFIDNTY SCSGKLLERE IKALLTPEDY QRFLDLGISI
360 AENRSAFSYH CKTPDCKGWC FFEDDVNEFT CPVCFHVNCL LCKAIHEQMN CKEYQEDLAL
420 RAQNDVAARQ TTEMLKVMLQ QGEAMRCPQC QIVVQKKDGC DWIRCTVCHT EICWVTKGPR
480 WGPGGPGDTS GGCRCRVNGI PCHPSCQNCH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
44103
Cong Y.-S.,Yao Y.-L.,Yang W.-M.,Kuzhandaivelu N.,Seto E.
The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein.
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Yamanaka K.,Ishikawa H.,Megumi Y.,Tokunaga F.,Kanie M.,Rouault T.A.,Morishima I.,Minato N.,Ishimori K.,Iwai K.
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Nat. Cell Biol.
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2003
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The DNA sequence and comparative analysis of human chromosome 20.
Nature
414
865-871
2001
44106
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
44107
Hillman R.T.,Green R.E.,Brenner S.E.
An unappreciated role for RNA surveillance.
Genome Biol.
5
0-0
2004
44108
Zhang Y.,Wolf-Yadlin A.,Ross P.L.,Pappin D.J.,Rush J.,Lauffenburger D.A.,White F.M.
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.
Mol. Cell. Proteomics
4
1240-1250
2005
44109
Kirisako T.,Kamei K.,Murata S.,Kato M.,Fukumoto H.,Kanie M.,Sano S.,Tokunaga F.,Tanaka K.,Iwai K.
A ubiquitin ligase complex assembles linear polyubiquitin chains.
EMBO J.
25
4877-4887
2006
44110
Tian Y.,Zhang Y.,Zhong B.,Wang Y.Y.,Diao F.C.,Wang R.P.,Zhang M.,Chen D.Y.,Zhai Z.H.,Shu H.B.
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
J. Biol. Chem.
282
16776-16782
2007
44111
Zhang M.,Tian Y.,Wang R.P.,Gao D.,Zhang Y.,Diao F.C.,Chen D.Y.,Zhai Z.H.,Shu H.B.
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
Cell Res.
18
1096-1104
2008
44112
Haas T.L.,Emmerich C.H.,Gerlach B.,Schmukle A.C.,Cordier S.M.,Rieser E.,Feltham R.,Vince J.,Warnken U.,Wenger T.,Koschny R.,Komander D.,Silke J.,Walczak H.
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
Mol. Cell
36
831-844
2009
44113
Tokunaga F.,Sakata S.,Saeki Y.,Satomi Y.,Kirisako T.,Kamei K.,Nakagawa T.,Kato M.,Murata S.,Yamaoka S.,Yamamoto M.,Akira S.,Takao T.,Tanaka K.,Iwai K.
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Nat. Cell Biol.
11
123-132
2009
44114
Gerlach B.,Cordier S.M.,Schmukle A.C.,Emmerich C.H.,Rieser E.,Haas T.L.,Webb A.I.,Rickard J.A.,Anderton H.,Wong W.W.,Nachbur U.,Gangoda L.,Warnken U.,Purcell A.W.,Silke J.,Walczak H.
Linear ubiquitination prevents inflammation and regulates immune signalling.
Nature
471
591-596
2011
44115
Tokunaga F.,Nakagawa T.,Nakahara M.,Saeki Y.,Taniguchi M.,Sakata S.,Tanaka K.,Nakano H.,Iwai K.
SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
Nature
471
633-636
2011
44116
Ikeda F.,Deribe Y.L.,Skanland S.S.,Stieglitz B.,Grabbe C.,Franz-Wachtel M.,van Wijk S.J.,Goswami P.,Nagy V.,Terzic J.,Tokunaga F.,Androulidaki A.,Nakagawa T.,Pasparakis M.,Iwai K.,Sundberg J.P.,Schaefer L.,Rittinger K.,Macek B.,Dikic I.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis.
Nature
471
637-641
2011
44117
Boisson B.,Laplantine E.,Prando C.,Giliani S.,Israelsson E.,Xu Z.,Abhyankar A.,Israel L.,Trevejo-Nunez G.,Bogunovic D.,Cepika A.M.,MacDuff D.,Chrabieh M.,Hubeau M.,Bajolle F.,Debre M.,Mazzolari E.,Vairo D.,Agou F.,Virgin H.W.,Bossuyt X.,Rambaud C.,Facchetti F.,Bonnet D.,Quartier P.,Fournet J.C.,Pascual V.,Chaussabel D.,Notarangelo L.D.,Puel A.,Israel A.,Casanova J.L.,Picard C.
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
Nat. Immunol.
13
1178-1186
2012
44118
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
44119
Nilsson J.,Schoser B.,Laforet P.,Kalev O.,Lindberg C.,Romero N.B.,Davila Lopez M.,Akman H.O.,Wahbi K.,Iglseder S.,Eggers C.,Engel A.G.,Dimauro S.,Oldfors A.
Polyglucosan body myopathy caused by defective ubiquitin ligase RBCK1.
Ann. Neurol.
74
914-919
2013
44120
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
44121
Rivkin E.,Almeida S.M.,Ceccarelli D.F.,Juang Y.C.,Maclean T.A.,Srikumar T.,Huang H.,Dunham W.H.,Fukumura R.,Xie G.,Gondo Y.,Raught B.,Gingras A.C.,Sicheri F.,Cordes S.P.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature
498
318-324
2013
44122
de Jong M.F.,Liu Z.,Chen D.,Alto N.M.
Shigella flexneri suppresses NF-kappaB activation by inhibiting linear ubiquitin chain ligation.
Nat. Microbiol.
1
16084-16084
2016
44123
Noad J.,von der Malsburg A.,Pathe C.,Michel M.A.,Komander D.,Randow F.
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-kappaB.
Nat. Microbiol.
2
17063-17063
2017
44125
Yagi H.,Ishimoto K.,Hiromoto T.,Fujita H.,Mizushima T.,Uekusa Y.,Yagi-Utsumi M.,Kurimoto E.,Noda M.,Uchiyama S.,Tokunaga F.,Iwai K.,Kato K.
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
EMBO Rep.
13
462-468
2012
44126
Beasley S.A.,Safadi S.S.,Barber K.R.,Shaw G.S.
Solution structure of the E3 ligase HOIL-1 Ubl domain.
Protein Sci.
21
1085-1092
2012
