Sequence of HMDH_METTH
EC Number:1.1.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
O26662
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
397
42160
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Other sequences found for EC No. 1.1.1.34
General information:
Sequence
0 MSIMDDLMEG RIKLYEIERH VPVDEAVRIR REFIERTCGV KLEHVSNYSI DMERASRRNI
60 ENPIGVVQIP LGVAGPLRVR GEHADGEYYV PLATSEGALV ASVNRGCSVI TRAGGATVRV
120 TGDSMTRAPV IRTGSVVEAL QLREWIYENM DALREEAEST TRHGKLVKID PIIVAGSYVY
180 PRFVYTTGDS MGMNMVTIAT ERALELLTRE TGAHVIALSG NLCTDKKPAA VNLIEGRGKS
240 ITAEITVPGE MVESVLKTTP EAVVEVNTAK NLIGSAAAGS MGFNAHYANI IGAIFLATGQ
300 DEAHIVEGSL GVTIAEERKG DLYFAVNLPD VPLATVGGGT GLETASECLD IMGVRGGGRV
360 HAFAEIVGGA VLAGELSLMG ALAAGHLARA HSELGRG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
43803
Smith D.R.,Doucette-Stamm L.A.,Deloughery C.,Lee H.-M.,Dubois J.,Aldredge T.,Bashirzadeh R.,Blakely D.,Cook R.,Gilbert K.,Harrison D.,Hoang L.,Keagle P.,Lumm W.,Pothier B.,Qiu D.,Spadafora R.,Vicare R.,Wang Y.,Wierzbowski J.,Gibson R.,Jiwani N.,Caruso A.,Bush D.,Safer H.,Patwell D.,Prabhakar S.,McDougall S.,Shimer G.,Goyal A.,Pietrovski S.,Church G.M.,Daniels C.J.,Mao J.-I.,Rice P.,Noelling J.,Reeve J.N.
Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.
J. Bacteriol.
179
7135-7155
1997
