Sequence of KAT2B_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
histone acetyltransferase
Q92831
Homo sapiens
832
93013
Reaction
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSEAGGAGPG GCGAGAGAGA GPGALPPQPA ALPPAPPQGS PCAAAAGGSG ACGPATAVAA
 60 AGTAEGPGGG GSARIAVKKA QLRSAPRAKK LEKLGVYSAC KAEESCKCNG WKNPNPSPTP
120 PRADLQQIIV SLTESCRSCS HALAAHVSHL ENVSEEEMNR LLGIVLDVEY LFTCVHKEED
180 ADTKQVYFYL FKLLRKSILQ RGKPVVEGSL EKKPPFEKPS IEQGVNNFVQ YKFSHLPAKE
240 RQTIVELAKM FLNRINYWHL EAPSQRRLRS PNDDISGYKE NYTRWLCYCN VPQFCDSLPR
300 YETTQVFGRT LLRSVFTVMR RQLLEQARQE KDKLPLEKRT LILTHFPKFL SMLEEEVYSQ
360 NSPIWDQDFL SASSRTSQLG IQTVINPPPV AGTISYNSTS SSLEQPNAGS SSPACKASSG
420 LEANPGEKRK MTDSHVLEEA KKPRVMGDIP MELINEVMST ITDPAAMLGP ETNFLSAHSA
480 RDEAARLEER RGVIEFHVVG NSLNQKPNKK ILMWLVGLQN VFSHQLPRMP KEYITRLVFD
540 PKHKTLALIK DGRVIGGICF RMFPSQGFTE IVFCAVTSNE QVKGYGTHLM NHLKEYHIKH
600 DILNFLTYAD EYAIGYFKKQ GFSKEIKIPK TKYVGYIKDY EGATLMGCEL NPRIPYTEFS
660 VIIKKQKEII KKLIERKQAQ IRKVYPGLSC FKDGVRQIPI ESIPGIRETG WKPSGKEKSK
720 EPRDPDQLYS TLKSILQQVK SHQSAWPFME PVKRTEAPGY YEVIRFPMDL KTMSERLKNR
780 YYVSKKLFMA DLQRVFTNCK EYNPPESEYY KCANILEKFF FSKIKEAGLI DK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
46356
Yang X.-J.,Ogryzko V.V.,Nishikawa J.,Howard B.H.,Nakatani Y.
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
Nature
382
319-324
1996
46358
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
46359
Ogryzko V.V.,Schiltz R.L.,Russanova V.,Howard B.H.,Nakatani Y.
The transcriptional coactivators p300 and CBP are histone acetyltransferases.
Cell
87
953-959
1996
46360
Takeshita A.,Cardona G.R.,Koibuchi N.,Suen C.-S.,Chin W.W.
TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
J. Biol. Chem.
272
27629-27634
1997
46361
Spencer T.E.,Jenster G.,Burcin M.M.,Allis C.D.,Zhou J.,Mizzen C.A.,McKenna N.J.,Onate S.A.,Tsai S.Y.,Tsai M.-J.,O'Malley B.W.
Steroid receptor coactivator-1 is a histone acetyltransferase.
Nature
389
194-198
1997
46362
Zhang W.,Bieker J.J.
Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with histone acetyltransferases.
Proc. Natl. Acad. Sci. U.S.A.
95
9855-9860
1998
46363
Martinez-Balbas M.A.,Bauer U.M.,Nielsen S.J.,Brehm A.,Kouzarides T.
Regulation of E2F1 activity by acetylation.
EMBO J.
19
662-671
2000
46364
Harrod R.,Kuo Y.-L.,Tang Y.,Yao Y.,Vassilev A.,Nakatani Y.,Giam C.-Z.
p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex.
J. Biol. Chem.
275
11852-11857
2000
46365
Chakraborty S.,Senyuk V.,Sitailo S.,Chi Y.,Nucifora G.
Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles.
J. Biol. Chem.
276
44936-44943
2001
46366
Bres V.,Tagami H.,Peloponese J.-M.,Loret E.,Jeang K.-T.,Nakatani Y.,Emiliani S.,Benkirane M.,Kiernan R.E.
Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.
EMBO J.
21
6811-6819
2002
46367
Curtis A.M.,Seo S.B.,Westgate E.J.,Rudic R.D.,Smyth E.M.,Chakravarti D.,FitzGerald G.A.,McNamara P.
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
J. Biol. Chem.
279
7091-7097
2004
46368
Zhao Q.,Cumming H.,Cerruti L.,Cunningham J.M.,Jane S.M.
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
J. Biol. Chem.
279
41477-41486
2004
46369
Gangisetty O.,Lauffart B.,Sondarva G.V.,Chelsea D.M.,Still I.H.
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
Oncogene
23
2559-2563
2004
46370
Huq M.D.,Gupta P.,Tsai N.P.,Wei L.N.
Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation.
Mol. Cell. Proteomics
5
2072-2082
2006
46371
Shin S.,Janknecht R.
Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.
J. Cell. Biochem.
101
1252-1265
2007
46372
Wiper-Bergeron N.,Salem H.A.,Tomlinson J.J.,Wu D.,Hache R.J.
Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Proc. Natl. Acad. Sci. U.S.A.
104
2703-2708
2007
46373
Burgio G.,Corona D.F.,Nicotra C.M.,Carruba G.,Taibi G.
P/CAF-mediated spermidine acetylation regulates histone acetyltransferase activity.
J. Enzym. Inhib. Med. Chem.
31
75-82
2016
46374
Zhu P.,Zhou W.,Wang J.,Puc J.,Ohgi K.A.,Erdjument-Bromage H.,Tempst P.,Glass C.K.,Rosenfeld M.G.
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
Mol. Cell
27
609-621
2007
46375
Gururaj A.E.,Peng S.,Vadlamudi R.K.,Kumar R.
Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).
Mol. Endocrinol.
21
1847-1860
2007
46376
Lin R.,Tao R.,Gao X.,Li T.,Zhou X.,Guan K.L.,Xiong Y.,Lei Q.Y.
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Mol. Cell
51
506-518
2013
46377
Fournier M.,Orpinell M.,Grauffel C.,Scheer E.,Garnier J.M.,Ye T.,Chavant V.,Joint M.,Esashi F.,Dejaegere A.,Goenczy P.,Tora L.
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Nat. Commun.
7
13227-13227
2016
46378
Ghosh T.K.,Aparicio-Sanchez J.J.,Buxton S.,Ketley A.,Mohamed T.,Rutland C.S.,Loughna S.,Brook J.D.
Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
J. Mol. Cell. Cardiol.
114
185-198
2017
46379
Clements A.,Rojas J.R.,Trievel R.C.,Wang L.,Berger S.L.,Marmorstein R.
Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.
EMBO J.
18
3521-3532
1999
46380
Dhalluin C.,Carlson J.E.,Zeng L.,He C.,Aggarwal A.K.,Zhou M.-M.
Structure and ligand of a histone acetyltransferase bromodomain.
Nature
399
491-496
1999
46381
Mujtaba S.,He Y.,Zeng L.,Farooq A.,Carlson J.E.,Ott M.,Verdin E.,Zhou M.-M.
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
Mol. Cell
9
575-586
2002
46382
Filippakopoulos P.,Picaud S.,Mangos M.,Keates T.,Lambert J.P.,Barsyte-Lovejoy D.,Felletar I.,Volkmer R.,Muller S.,Pawson T.,Gingras A.C.,Arrowsmith C.H.,Knapp S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell
149
214-231
2012
46383
Rainger J.,Williamson K.A.,Soares D.C.,Truch J.,Kurian D.,Gillessen-Kaesbach G.,Seawright A.,Prendergast J.,Halachev M.,Wheeler A.,McTeir L.,Gill A.C.,van Heyningen V.,Davey M.G.,FitzPatrick D.R.
A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.
Hum. Mutat.
38
942-946
2017