Sequence of KAT2A_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
histone acetyltransferase
Q92830
Homo sapiens
837
93926
Reaction
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAEPSQAPTP APAAQPRPLQ SPAPAPTPTP APSPASAPIP TPTPAPAPAP AAAPAGSTGT
 60 GGPGVGSGGA GSGGDPARPG LSQQQRASQR KAQVRGLPRA KKLEKLGVFS ACKANETCKC
120 NGWKNPKPPT APRMDLQQPA ANLSELCRSC EHPLADHVSH LENVSEDEIN RLLGMVVDVE
180 NLFMSVHKEE DTDTKQVYFY LFKLLRKCIL QMTRPVVEGS LGSPPFEKPN IEQGVLNFVQ
240 YKFSHLAPRE RQTMFELSKM FLLCLNYWKL ETPAQFRQRS QAEDVATYKV NYTRWLCYCH
300 VPQSCDSLPR YETTHVFGRS LLRSIFTVTR RQLLEKFRVE KDKLVPEKRT LILTHFPKFL
360 SMLEEEIYGA NSPIWESGFT MPPSEGTQLV PRPASVSAAV VPSTPIFSPS MGGGSNSSLS
420 LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL
480 SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA
540 RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE
600 YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP
660 YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG
720 KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE
780 RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
46322
Candau R.,Moore P.A.,Wang L.,Barlev N.,Ying C.Y.,Rosen C.A.,Berger S.L.
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.
Mol. Cell. Biol.
16
593-602
1996
46323
Smith E.R.,Belote J.M.,Schlitz R.L.,Yang X.-J.,Moore P.A.,Berger S.L.,Nakatani Y.,Allis C.D.
Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members.
Nucleic Acids Res.
26
2948-2954
1998
46325
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
46326
Yang X.-J.,Ogryzko V.V.,Nishikawa J.,Howard B.H.,Nakatani Y.
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
Nature
382
319-324
1996
46327
Martinez E.,Palhan V.B.,Tjernberg A.,Lymar E.S.,Gamper A.M.,Kundu T.K.,Chait B.T.,Roeder R.G.
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
Mol. Cell. Biol.
21
6782-6795
2001
46328
Brand M.,Yamamoto K.,Staub A.,Tora L.
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
J. Biol. Chem.
274
18285-18289
1999
46329
McMahon S.B.,Wood M.A.,Cole M.D.
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc.
Mol. Cell. Biol.
20
556-562
2000
46330
Col E.,Caron C.,Seigneurin-Berny D.,Gracia J.,Favier A.,Khochbin S.
The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat.
J. Biol. Chem.
276
28179-28184
2001
46331
Gangloff Y.G.,Pointud J.-C.,Thuault S.,Carre L.,Romier C.,Muratoglu S.,Brand M.,Tora L.,Couderc J.-L.,Davidson I.
The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger.
Mol. Cell. Biol.
21
5109-5121
2001
46332
Gangisetty O.,Lauffart B.,Sondarva G.V.,Chelsea D.M.,Still I.H.
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
Oncogene
23
2559-2563
2004
46333
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
46334
Wiper-Bergeron N.,Salem H.A.,Tomlinson J.J.,Wu D.,Hache R.J.
Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Proc. Natl. Acad. Sci. U.S.A.
104
2703-2708
2007
46335
Zhao Y.,Lang G.,Ito S.,Bonnet J.,Metzger E.,Sawatsubashi S.,Suzuki E.,Le Guezennec X.,Stunnenberg H.G.,Krasnov A.,Georgieva S.G.,Schuele R.,Takeyama K.,Kato S.,Tora L.,Devys D.
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
Mol. Cell
29
92-101
2008
46336
Guelman S.,Kozuka K.,Mao Y.,Pham V.,Solloway M.J.,Wang J.,Wu J.,Lill J.R.,Zha J.
The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
Mol. Cell. Biol.
29
1176-1188
2009
46337
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
46338
Ghosh T.K.,Aparicio-Sanchez J.J.,Buxton S.,Ketley A.,Mohamed T.,Rutland C.S.,Loughna S.,Brook J.D.
Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.
J. Mol. Cell. Cardiol.
114
185-198
2017
46339
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
46340
Hudson B.P.,Martinez-Yamout M.A.,Dyson H.J.,Wright P.E.
Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain.
J. Mol. Biol.
304
355-370
2000
46341
Schuetz A.,Bernstein G.,Dong A.,Antoshenko T.,Wu H.,Loppnau P.,Bochkarev A.,Plotnikov A.N.
Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A.
Proteins
68
403-407
2007
46342
Filippakopoulos P.,Picaud S.,Mangos M.,Keates T.,Lambert J.P.,Barsyte-Lovejoy D.,Felletar I.,Volkmer R.,Muller S.,Pawson T.,Gingras A.C.,Arrowsmith C.H.,Knapp S.
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell
149
214-231
2012
46343
Fournier M.,Orpinell M.,Grauffel C.,Scheer E.,Garnier J.M.,Ye T.,Chavant V.,Joint M.,Esashi F.,Dejaegere A.,Goenczy P.,Tora L.
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Nat. Commun.
7
13227-13227
2016
46344
Wang Y.,Guo Y.R.,Liu K.,Yin Z.,Liu R.,Xia Y.,Tan L.,Yang P.,Lee J.H.,Li X.J.,Hawke D.,Zheng Y.,Qian X.,Lyu J.,He J.,Xing D.,Tao Y.J.,Lu Z.
KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.
Nature
552
273-277
2017