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Sequence of QSOX1_HUMAN

EC Number:1.8.3.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
thiol oxidase
O00391
Homo sapiens
747
82578
Reaction
2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2

General information:

Sequence
show sequence in fasta format
  0 MRRCNSGSGP PPSLLLLLLW LLAVPGANAA PRSALYSPSD PLTLLQADTV RGAVLGSRSA
 60 WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD CAEETNSAVC RDFNIPGFPT
120 VRFFKAFTKN GSGAVFPVAG ADVQTLRERL IDALESHHDT WPPACPPLEP AKLEEIDGFF
180 ARNNEEYLAL IFEKGGSYLG REVALDLSQH KGVAVRRVLN TEANVVRKFG VTDFPSCYLL
240 FRNGSVSRVP VLMESRSFYT AYLQRLSGLT REAAQTTVAP TTANKIAPTV WKLADRSKIY
300 MADLESALHY ILRIEVGRFP VLEGQRLVAL KKFVAVLAKY FPGRPLVQNF LHSVNEWLKR
360 QKRNKIPYSF FKTALDDRKE GAVLAKKVNW IGCQGSEPHF RGFPCSLWVL FHFLTVQAAR
420 QNVDHSQEAA KAKEVLPAIR GYVHYFFGCR DCASHFEQMA AASMHRVGSP NAAVLWLWSS
480 HNRVNARLAG APSEDPQFPK VQWPPRELCS ACHNERLDVP VWDVEATLNF LKAHFSPSNI
540 ILDFPAAGSA ARRDVQNVAA APELAMGALE LESRNSTLDP GKPEMMKSPT NTTPHVPAEG
600 PEASRPPKLH PGLRAAPGQE PPEHMAELQR NEQEQPLGQW HLSKRDTGAA LLAESRAEKN
660 RLWGPLEVRR VGRSSKQLVD IPEGQLEARA GRGRGQWLQV LGGGFSYLDI SLCVGLYSLS
720 FMGLLAMYTY FQAKIRALKG HAGHPAA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
237474
Coppock D.L.,Cina-Poppe D.,Gilleran S.
The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1.
Genomics
54
460-468
1998
237475
Radom J.,Colin D.,Thiebault F.,Dognin-Bergeret M.J.,Mairet-Coello G.,Esnard-Feve A.,Fellmann D.,Jouvenot M.
Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain.
Biochim. Biophys. Acta
1759
225-233
2006
237476
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
237478
Gregory S.G.,Barlow K.F.,McLay K.E.,Kaul R.,Swarbreck D.,Dunham A.,Scott C.E.,Howe K.L.,Woodfine K.,Spencer C.C.A.,Jones M.C.,Gillson C.,Searle S.,Zhou Y.,Kokocinski F.,McDonald L.,Evans R.,Phillips K.,Atkinson A.,Cooper R.,Jones C.,Hall R.E.,Andrews T.D.,Lloyd C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Anderson F.,Andrew R.W.,Ashwell R.I.S.,Aubin K.,Babbage A.K.,Bagguley C.L.,Bailey J.,Beasley H.,Bethel G.,Bird C.P.,Bray-Allen S.,Brown J.Y.,Brown A.J.,Buckley D.,Burton J.,Bye J.,Carder C.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.,Cobley V.,Collier R.E.,Corby N.,Coville G.J.,Davies J.,Deadman R.,Dunn M.,Earthrowl M.,Ellington A.G.,Errington H.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Gay L.,Ghori M.R.J.,Gibson R.,Gilby L.M.,Gillett W.,Glithero R.J.,Grafham D.V.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Hammond S.,Harrison E.S.I.,Hart E.,Haugen E.,Heath P.D.,Holmes S.,Holt K.,Howden P.J.,Hunt A.R.,Hunt S.E.,Hunter G.,Isherwood J.,James R.,Johnson C.,Johnson D.,Joy A.,Kay M.,Kershaw J.K.,Kibukawa M.,Kimberley A.M.,King A.,Knights A.J.,Lad H.,Laird G.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Loveland J.,Lovell J.,Lush M.J.,Lyne R.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,Matthews N.S.W.,McLaren S.,Milne S.,Mistry S.,Moore M.J.F.,Nickerson T.,O'Dell C.N.,Oliver K.,Palmeiri A.,Palmer S.A.,Parker A.,Patel D.,Pearce A.V.,Peck A.I.,Pelan S.,Phelps K.,Phillimore B.J.,Plumb R.,Rajan J.,Raymond C.,Rouse G.,Saenphimmachak C.,Sehra H.K.,Sheridan E.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.,Steward C.,Subramanian S.,Sycamore N.,Tracey A.,Tromans A.,Van Helmond Z.,Wall M.,Wallis J.M.,White S.,Whitehead S.L.,Wilkinson J.E.,Willey D.L.,Williams H.,Wilming L.,Wray P.W.,Wu Z.,Coulson A.,Vaudin M.,Sulston J.E.,Durbin R.M.,Hubbard T.,Wooster R.,Dunham I.,Carter N.P.,McVean G.,Ross M.T.,Harrow J.,Olson M.V.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence and biological annotation of human chromosome 1.
Nature
441
315-321
2006
237479
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
237480
Coppock D.L.,Kopman C.,Gudas J.,Cina-Poppe D.A.
Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29.
Biochem. Biophys. Res. Commun.
269
604-610
2000
237482
Thorpe C.,Hoober K.L.,Raje S.,Glynn N.M.,Burnside J.,Turi G.K.,Coppock D.L.
Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes.
Arch. Biochem. Biophys.
405
1-12
2002
237483
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
237484
Chakravarthi S.,Jessop C.E.,Willer M.,Stirling C.J.,Bulleid N.J.
Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1.
Biochem. J.
404
403-411
2007
237485
Heckler E.J.,Alon A.,Fass D.,Thorpe C.
Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis.
Biochemistry
47
4955-4963
2008
237486
Jia W.,Lu Z.,Fu Y.,Wang H.P.,Wang L.H.,Chi H.,Yuan Z.F.,Zheng Z.B.,Song L.N.,Han H.H.,Liang Y.M.,Wang J.L.,Cai Y.,Zhang Y.K.,Deng Y.L.,Ying W.T.,He S.M.,Qian X.H.
A strategy for precise and large scale identification of core fucosylated glycoproteins.
Mol. Cell. Proteomics
8
913-923
2009
237487
Tagliabracci V.S.,Wiley S.E.,Guo X.,Kinch L.N.,Durrant E.,Wen J.,Xiao J.,Cui J.,Nguyen K.B.,Engel J.L.,Coon J.J.,Grishin N.,Pinna L.A.,Pagliarini D.J.,Dixon J.E.
A single kinase generates the majority of the secreted phosphoproteome.
Cell
161
1619-1632
2015
237488
Ilani T.,Alon A.,Grossman I.,Horowitz B.,Kartvelishvily E.,Cohen S.R.,Fass D.
A secreted disulfide catalyst controls extracellular matrix composition and function.
Science
341
74-76
2013
237489
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
237490
Grossman I.,Ilani T.,Fleishman S.J.,Fass D.
Overcoming a species-specificity barrier in development of an inhibitory antibody targeting a modulator of tumor stroma.
Protein Eng. Des. Sel.
29
135-147
2016
237491
Horowitz B.,Javitt G.,Ilani T.,Gat Y.,Morgenstern D.,Bard F.A.,Fass D.
Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization.
Glycobiology
28
580-591
2018
237492
Javitt G.,Grossman-Haham I.,Alon A.,Resnick E.,Mutsafi Y.,Ilani T.,Fass D.
cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures.
Protein Sci.
28
228-238
2019
237493
Alon A.,Heckler E.J.,Thorpe C.,Fass D.
QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.
FEBS Lett.
584
1521-1525
2010
237494
Alon A.,Grossman I.,Gat Y.,Kodali V.K.,DiMaio F.,Mehlman T.,Haran G.,Baker D.,Thorpe C.,Fass D.
The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature
488
414-418
2012
237495
Grossman I.,Alon A.,Ilani T.,Fass D.
An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1.
J. Mol. Biol.
425
4366-4378
2013