Sequence of HGXR_TOXGO
EC Number:2.4.2.8
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Other sequences found for EC No. 2.4.2.8
General information:
Sequence
0 MASKPIEDYG KGKGRIEPMY IPDNTFYNAD DFLVPPHCKP YIDKILLPGG LVKDRVEKLA
60 YDIHRTYFGE ELHIICILKG SRGFFNLLID YLATIQKYSG RESSVPPFFE HYVRLKSYQN
120 DNSTGQLTVL SDDLSIFRDK HVLIVEDIVD TGFTLTEFGE RLKAVGPKSM RIATLVEKRT
180 DRSNSLKGDF VGFSIEDVWI VGCCYDFNEM FRDFDHVAVL SDAARKKFEK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
42969
Vasanthakumar G.,van Ginkel S.,Parish G.
Isolation and sequencing of a cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase from Toxoplasma gondii.
Gene
147
153-154
1994
42970
Schumacher M.A.,Carter D.,Roos D.S.,Ullman B.,Brennan R.G.
Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop.
Nat. Struct. Biol.
3
881-887
1996
42971
Heroux A.,White E.L.,Ross L.J.,Borhani D.W.
Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex.
Biochemistry
38
14485-14494
1999
42972
Heroux A.,White E.L.,Ross L.J.,Davis R.L.,Borhani D.W.
Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with bound XMP, pyrophosphate and two Mg2+ ions: insights into the catalytic mechanism.
Biochemistry
38
14495-14506
1999
42973
Heroux A.,White E.L.,Ross L.J.,Kuzin A.P.,Borhani D.W.
Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
Structure
8
1309-1318
2000
