Sequence of POL_SIVSP
EC Number:3.1.26.13
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
retroviral ribonuclease H
P19505
Simian immunodeficiency virus (isolate PBj14/BCL-3)
1449
163326
Reaction
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Other sequences found for EC No. 3.1.26.13
General information:
Sequence
0 MGARNSVLSG KKADELEKIR LRPGGKKRYQ LKHIVWAANE LDRFGLAESL LENKEGCQKI
60 LSVLAPLVPT GSENLKSLYN TVCVLWCIHA EEKVKHTEEA KQIVQRHLVV ETGTADKMPA
120 TSRPTAPPSG KGGNYPVQQI GGNYTHLPLS PRTLNAWVKL IEEKKFGAEV VPGFQALSEG
180 CTPYDINQML NCVGEHQAAM QIIREIINEE AADWDLQHPQ PGPIPPGQLR EPRGSDIAGT
240 TSTVDEQIQW MYRQQNPIPV GNIYRRWIQL GLQKCVRMYN PTNILDVKQG PKEPFQSYVD
300 RFYKSLRAEQ TDPAVKNWMT QTLLIQNANP DCKLVLKGLG INPTLEEMLT ACQGVGGPGQ
360 KARLMAEALK DALTQGPLPF AAVQQKGQRK IIKCWNCGKE GHSARQCRAP RRQGCWKCGK
420 AGHVMAKCPE RQAGFFRAWP MGKEAPQFPH GPDASGADTN CSPRGSSCGS TEELHEDGQK
480 AEGEQRETLQ GGNGGFAAPQ FSLWRRPIVT AYIEEQPVEV LLDTGADDSI VAGIELGPNY
540 TPKIVGGIGG FINTKEYKDV KIKVLGKVIK GTIMTGDTPI NIFGRNLLTA MGMSLNLPIA
600 KVEPIKVTLK PGKDGPKLRQ WPLSKEKIIA LREICEKMEK DGQLEEAPPT NPYNTPTFAI
660 KKKDKNKWRM LIDFRELNKV TQDFTEVQLG IPHPAGLAKR RRITVLDVGD AYFSIPLDEE
720 FRQYTAFTLP SVNNAEPGKR YIYKVLPQGW KGSPAIFQHT MRNVLEPFRK ANPDVTLIQY
780 MDDILIASDR TDLEHDRVVL QLKELLNSIG FSTPEEKFQK DPPFQWMGYE LWPTKWKLQK
840 IELPQRETWT VNDIQKLVGV LNWAAQIYPG IKTKHLCRLI RGKMTLTEEV QWTEMAEAEY
900 EENKIILSQE QEGCYYQEGK PLEATVIKSQ DNQWSYKIHQ EDKILKVGKF AKIKNTHTNG
960 VRLLAHVVQK IGKEAIVIWG QVPRFHLPVE REIWEQWWTD YWQVTWIPEW DFVSTPPLVR
1020 LVFNLVKEPI QGAETFYVDG SCNRQSREGK AGYVTDRGRD KAKLLEQTTN QQAELEAFYL
1080 ALADSGPKAN IIVDSQYVMG IVAGQPTESE SRLVNQIIEE MIKKEAIYVA WVPAHKGIGG
1140 NQEVDHLVSQ GIRQVLFLEK IEPAQEEHEK YHSNVKELVF KFGLPRLVAK QIVDTCDKCH
1200 QKGEAIHGQV NAELGTWQMD CTHLEGKIII VAVHVASGFI EAEVIPQETG RQTALFLLKL
1260 ASRWPITHLH TDNGANFTSQ EVKMVAWWAG IEQTFGVPYN PQSQGVVEAM NHHLKTQIDR
1320 IREQANSIET IVLMAVHCMN FKRRGGIGDM TPAERLVNMI TTEQEIQFQQ SKNSKFKNFR
1380 VYYREGRDQL WKGPGELLWK GEGAVILKVG TEIKVVPRRK AKIIKDYGGG KELDSGSHLE
1440 DTGEAREVA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
460805
Dewhurst S.,Embretson J.E.,Anderson D.C.,Mullins J.I.,Fultz P.N.
Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM-PBj14.
Nature
345
636-640
1990
460806
Dewhurst S.,Embretson J.E.,Fultz P.N.,Mullins J.I.
Molecular clones from a non-acutely pathogenic derivative of SIVsmmPBj14: characterization and comparison to acutely pathogenic clones.
AIDS Res. Hum. Retroviruses
8
1179-1187
1992
