Sequence of POLG_HCVJ4
EC Number:3.4.21.98
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'
Other sequences found for EC No. 3.4.21.98
General information:
Sequence
0 MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR KASERSQPRG
60 RRQPIPKARR PEGRAWAQPG YPWPLYGNEG LGWAGWLLSP RGSRPSWGPT DPRRRSRNLG
120 KVIDTLTCGF ADLMGYIPLV GAPLGGAARA LAHGVRVLED GVNYATGNLP GCSFSIFLLA
180 LLSCLTIPAS AYEVRNVSGI YHVTNDCSNS SIVYEAADVI MHTPGCVPCV REGNSSRCWV
240 ALTPTLAARN ASVPTTTIRR HVDLLVGTAA FCSAMYVGDL CGSIFLVSQL FTFSPRRHET
300 VQDCNCSIYP GHVSGHRMAW DMMMNWSPTT ALVVSQLLRI PQAVVDMVAG AHWGVLAGLA
360 YYSMVGNWAK VLIVALLFAG VDGETHTTGR VAGHTTSGFT SLFSSGASQK IQLVNTNGSW
420 HINRTALNCN DSLQTGFFAA LFYAHKFNSS GCPERMASCR PIDWFAQGWG PITYTKPNSS
480 DQRPYCWHYA PRPCGVVPAS QVCGPVYCFT PSPVVVGTTD RSGVPTYSWG ENETDVMLLN
540 NTRPPQGNWF GCTWMNSTGF TKTCGGPPCN IGGVGNRTLI CPTDCFRKHP EATYTKCGSG
600 PWLTPRCLVD YPYRLWHYPC TLNFSIFKVR MYVGGVEHRL NAACNWTRGE RCNLEDRDRS
660 ELSPLLLSTT EWQILPCAFT TLPALSTGLI HLHQNIVDVQ YLYGVGSAFV SFAIKWEYIL
720 LLFLLLADAR VCACLWMMLL IAQAEAALEN LVVLNAASVA GAHGILSFLV FFCAAWYIKG
780 RLAPGAAYAF YGVWPLLLLL LALPPRAYAL DREMAASCGG AVLVGLVFLT LSPYYKVFLT
840 RLIWWLQYFI TRAEAHMQVW VPPLNVRGGR DAIILLTCAV HPELIFDITK LLLAILGPLM
900 VLQAGITRVP YFVRAQGLIR ACMLVRKVAG GHYVQMAFMK LGALTGTYVY NHLTPLRDWA
960 HAGLRDLAVA VEPVVFSAME TKVITWGADT AACGDIILGL PVSARRGKEI FLGPADSLEG
1020 QGWRLLAPIT AYSQQTRGVL GCIITSLTGR DKNQVEGEVQ VVSTATQSFL ATCINGVCWT
1080 VYHGAGSKTL AGPKGPITQM YTNVDLDLVG WQAPPGARSM TPCSCGSSDL YLVTRHADVI
1140 PVRRRGDSRG SLLSPRPVSY LKGSSGGPLL CPSGHVVGVF RAAVCTRGVA KAVDFIPVES
1200 METTMRSPVF TDNSSPPAVP QTFQVAHLHA PTGSGKSTKV PAAYAAQGYK VLVLNPSVAA
1260 TLGFGAYMSK AHGIDPNIRT GVRTITTGGS ITYSTYGKFL ADGGCSGGAY DIIICDECHS
1320 TDSTTILGIG TVLDQAETAG ARLVVLATAT PPGSVTVPHP NIEEIGLSNN GEIPFYGKAI
1380 PIEAIKGGRH LIFCHSKKKC DELAAKLTGL GLNAVAYYRG LDVSVIPPIG DVVVVATDAL
1440 MTGFTGDFDS VIDCNTCVTQ TVDFSLDPTF TIETTTVPQD AVSRSQRRGR TGRGRSGIYR
1500 FVTPGERPSG MFDSSVLCEC YDAGCAWYEL TPAETSVRLR AYLNTPGLPV CQDHLEFWES
1560 VFTGLTHIDA HFLSQTKQAG DNFPYLVAYQ ATVCARAQAP PPSWDQMWKC LIRLKPTLHG
1620 PTPLLYRLGA VQNEVILTHP ITKYIMACMS ADLEVVTSTW VLVGGVLAAL AAYCLTTGSV
1680 VIVGRIILSG KPAVVPDREV LYQEFDEMEE CASQLPYIEQ GMQLAEQFKQ KALGLLQTAT
1740 KQAEAAAPVV ESKWRALETF WAKHMWNFIS GIQYLAGLST LPGNPAIASL MAFTASITSP
1800 LTTQNTLLFN ILGGWVAAQL APPSAASAFV GAGIAGAAVG SIGLGKVLVD ILAGYGAGVA
1860 GALVAFKVMS GEVPSTEDLV NLLPAILSPG ALVVGVVCAA ILRRHVGPGE GAVQWMNRLI
1920 AFASRGNHVS PTHYVPESDA AARVTQILSS LTITQLLKRL HQWINEDCST PCSGSWLRDV
1980 WDWICTVLTD FKTWLQSKLL PRLPGVPFLS CQRGYKGVWR GDGIMQTTCP CGAQIAGHVK
2040 NGSMRIVGPR TCSNTWHGTF PINAYTTGPC TPSPAPNYSR ALWRVAAEEY VEVTRVGDFH
2100 YVTGMTTDNV KCPCQVPAPE FFTEVDGVRL HRYAPACKPL LREDVTFQVG LNQYLVGSQL
2160 PCEPEPDVTV LTSMLTDPSH ITAETAKRRL ARGSPPSLAS SSASQLSAPS LKATCTTHHD
2220 SPDADLIEAN LLWRQEMGGN ITRVESENKV VILDSFEPLH AEGDEREISV AAEILRKSRK
2280 FPSALPIWAR PDYNPPLLES WKDPDYVPPV VHGCPLPPTK APPIPPPRRK RTVVLTESNV
2340 SSALAELATK TFGSSGSSAV DSGTATALPD LASDDGDKGS DVESYSSMPP LEGEPGDPDL
2400 SDGSWSTVSE EASEDVVCCS MSYTWTGALI TPCAAEESKL PINPLSNSLL RHHNMVYATT
2460 SRSASLRQKK VTFDRLQVLD DHYRDVLKEM KAKASTVKAK LLSIEEACKL TPPHSAKSKF
2520 GYGAKDVRNL SSRAVNHIRS VWEDLLEDTE TPIDTTIMAK SEVFCVQPEK GGRKPARLIV
2580 FPDLGVRVCE KMALYDVVST LPQAVMGSSY GFQYSPKQRV EFLVNTWKSK KCPMGFSYDT
2640 RCFDSTVTES DIRVEESIYQ CCDLAPEARQ AIRSLTERLY IGGPLTNSKG QNCGYRRCRA
2700 SGVLTTSCGN TLTCYLKATA ACRAAKLQDC TMLVNGDDLV VICESAGTQE DAAALRAFTE
2760 AMTRYSAPPG DPPQPEYDLE LITSCSSNVS VAHDASGKRV YYLTRDPTTP LARAAWETAR
2820 HTPINSWLGN IIMYAPTLWA RMILMTHFFS ILLAQEQLEK ALDCQIYGAC YSIEPLDLPQ
2880 IIERLHGLSA FTLHSYSPGE INRVASCLRK LGVPPLRTWR HRARSVRAKL LSQGGRAATC
2940 GRYLFNWAVR TKLKLTPIPA ASQLDLSGWF VAGYSGGDIY HSLSRARPRW FPLCLLLLSV
3000 GVGIYLLPNR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
460629
Okamoto H.,Kojima M.,Okada S.,Yoshizawa H.,Iizuka H.,Tanaka T.,Muchmore E.E.,Peterson D.A.,Ito Y.,Mishiro S.
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability.
Virology
190
894-899
1992
460630
Yanagi M.,St Claire M.,Shapiro M.,Emerson S.U.,Purcell R.H.,Bukh J.
Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo.
Virology
244
161-172
1998
460631
Griffin S.D.,Beales L.P.,Clarke D.S.,Worsfold O.,Evans S.D.,Jaeger J.,Harris M.P.,Rowlands D.J.
The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine.
FEBS Lett.
535
34-38
2003
460632
Clarke D.,Griffin S.,Beales L.,Gelais C.S.,Burgess S.,Harris M.,Rowlands D.
Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro.
J. Biol. Chem.
281
37057-37068
2006
460633
Cramer J.,Jaeger J.,Restle T.
Biochemical and pre-steady-state kinetic characterization of the hepatitis C virus RNA polymerase (NS5BDelta21, HC-J4).
Biochemistry
45
3610-3619
2006
460634
Tedbury P.R.,Harris M.
Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities.
J. Mol. Biol.
366
1652-1660
2007
460635
O'Farrell D.,Trowbridge R.,Rowlands D.,Jager J.
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation.
J. Mol. Biol.
326
1025-1035
2003
