Sequence of CBPC1_CHICK
EC Number:3.4.17.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
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Reaction
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
General information:
Sequence
0 MKVKKNLTCS VSTSSRTMSL LSQLEKINLD SVLGEADNAR YVTAKILHLV QSQEKTKKEM
60 TSKGSSAIEV ILSTLENTRD PQTILNILSI LIELVSVGGG RRASVLVTKG GTQILLQLLL
120 NASKESPPNE ELMVLLHTLL AKIGPKDKKI GMKARINGAL NISLNLVKQN LQNHRLILPC
180 LQVLRVYSTN SVNAVSLGKN GVVELMFKII GPFSKKNTSL MKVALDTLAA LLKSKTNARR
240 AVDRGYVHML LTIYVDWHRH DSRHRYMLIR KGVLQCIKSV TNIKLGRKAF IDANGMKILY
300 NTSQECLAVR TLDPLVNTSS LIMRKCFPKN RLPLPTIKSA FHFQLPVIPA SGPVAQMYNL
360 PPDVDDVVDE SDDNDDAETE SEIETEDDKD QNFKNDDIET DINKLKPRQE LGRPLEELKM
420 YEQFFPELTE NFQECDLVSK EPKPFVSNAN LGGPIVVPTA GEEFSAETNP SVIGISLKEG
480 NPLLTEEYNR RPAFLGLPKK DSIKASSLLQ QNVQRNLLPS CQCLSQEIVT GLDRISLQNT
540 SENDQYYATG CVIKKDNKTS LTPLACSKTC EHVSPCGSSL FEGSSVHLGK FCCTGVESEE
600 EDSKSSSSGE QVVLEVSDVS PVHDCDLYIE MVKTTKSIPE YSEVAYPDYF GHIPPPFKEP
660 ILERPYGVQR TKISQDIERL IHQNDIIDRV VYDLDNSICS APEEVDVLKF NSKFESGNLR
720 KVIQIRKNEY DLILNSDINS NHYHQWFYFE VSGMKTGIGY RFNIINCEKS NSQFNYGMQP
780 LMYSVQEALN SRPSWTRVGT DICYYKNHFS RSSIAAGGQK GKSYYTITFT VTFQHKDDVC
840 YFAYHYPYTY STLKMHLQKL ESMHNPQQIY FRQDALCETL GGNICPIVTI TAMPESNYYE
900 HICQFRNRPY IFLSARVHPG ETNASWVMKG TLEYLMSSNP SAQSLRESYI FKIIPMLNPD
960 GVINGNHRCS LSGEDLNRQW QNPNPDLHPT IYHAKGLLQY LAAIKRLPLV YCDYHGHSRK
1020 KNVFMYGCSI KETMWHTNVN TASCDLMEDP GYRVLPKILS QTAPAFCMGS CSFVVEKSKE
1080 STARVVVWRE IGVQRSYTME STLCGCDQGK YKGLQIGTKE LEEMGAKFCV GLLRLKRMAS
1140 PLEYNLPSGL LDIENELIES SCKVTSPTTY VLDEDEPRFL EEVDYSAESN DDQDAELADN
1200 VGDYEANNQE DGLSDSDSTR ILLS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
214805
Hillier L.W.,Miller W.,Birney E.,Warren W.,Hardison R.C.,Ponting C.P.,Bork P.,Burt D.W.,Groenen M.A.M.,Delany M.E.,Dodgson J.B.,Chinwalla A.T.,Cliften P.F.,Clifton S.W.,Delehaunty K.D.,Fronick C.,Fulton R.S.,Graves T.A.,Kremitzki C.,Layman D.,Magrini V.,McPherson J.D.,Miner T.L.,Minx P.,Nash W.E.,Nhan M.N.,Nelson J.O.,Oddy L.G.,Pohl C.S.,Randall-Maher J.,Smith S.M.,Wallis J.W.,Yang S.-P.,Romanov M.N.,Rondelli C.M.,Paton B.,Smith J.,Morrice D.,Daniels L.,Tempest H.G.,Robertson L.,Masabanda J.S.,Griffin D.K.,Vignal A.,Fillon V.,Jacobbson L.,Kerje S.,Andersson L.,Crooijmans R.P.,Aerts J.,van der Poel J.J.,Ellegren H.,Caldwell R.B.,Hubbard S.J.,Grafham D.V.,Kierzek A.M.,McLaren S.R.,Overton I.M.,Arakawa H.,Beattie K.J.,Bezzubov Y.,Boardman P.E.,Bonfield J.K.,Croning M.D.R.,Davies R.M.,Francis M.D.,Humphray S.J.,Scott C.E.,Taylor R.G.,Tickle C.,Brown W.R.A.,Rogers J.,Buerstedde J.-M.,Wilson S.A.,Stubbs L.,Ovcharenko I.,Gordon L.,Lucas S.,Miller M.M.,Inoko H.,Shiina T.,Kaufman J.,Salomonsen J.,Skjoedt K.,Wong G.K.-S.,Wang J.,Liu B.,Wang J.,Yu J.,Yang H.,Nefedov M.,Koriabine M.,Dejong P.J.,Goodstadt L.,Webber C.,Dickens N.J.,Letunic I.,Suyama M.,Torrents D.,von Mering C.,Zdobnov E.M.,Makova K.,Nekrutenko A.,Elnitski L.,Eswara P.,King D.C.,Yang S.-P.,Tyekucheva S.,Radakrishnan A.,Harris R.S.,Chiaromonte F.,Taylor J.,He J.,Rijnkels M.,Griffiths-Jones S.,Ureta-Vidal A.,Hoffman M.M.,Severin J.,Searle S.M.J.,Law A.S.,Speed D.,Waddington D.,Cheng Z.,Tuzun E.,Eichler E.,Bao Z.,Flicek P.,Shteynberg D.D.,Brent M.R.,Bye J.M.,Huckle E.J.,Chatterji S.,Dewey C.,Pachter L.,Kouranov A.,Mourelatos Z.,Hatzigeorgiou A.G.,Paterson A.H.,Ivarie R.,Brandstrom M.,Axelsson E.,Backstrom N.,Berlin S.,Webster M.T.,Pourquie O.,Reymond A.,Ucla C.,Antonarakis S.E.,Long M.,Emerson J.J.,Betran E.,Dupanloup I.,Kaessmann H.,Hinrichs A.S.,Bejerano G.,Furey T.S.,Harte R.A.,Raney B.,Siepel A.,Kent W.J.,Haussler D.,Eyras E.,Castelo R.,Abril J.F.,Castellano S.,Camara F.,Parra G.,Guigo R.,Bourque G.,Tesler G.,Pevzner P.A.,Smit A.,Fulton L.A.,Mardis E.R.,Wilson R.K.
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.
Nature
432
695-716
2004
