Sequence of HEM2_ECOLI
EC Number:4.2.1.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2 5-aminolevulinate = porphobilinogen + 2 H2O
Other sequences found for EC No. 4.2.1.24
General information:
Sequence
0 MTDLIQRPRR LRKSPALRAM FEETTLSLND LVLPIFVEEE IDDYKAVEAM PGVMRIPEKH
60 LAREIERIAN AGIRSVMTFG ISHHTDETGS DAWREDGLVA RMSRICKQTV PEMIVMSDTC
120 FCEYTSHGHC GVLCEHGVDN DATLENLGKQ AVVAAAAGAD FIAPSAAMDG QVQAIRQALD
180 AAGFKDTAIM SYSTKFASSF YGPFREAAGS ALKGDRKSYQ MNPMNRREAI RESLLDEAQG
240 ADCLMVKPAG AYLDIVRELR ERTELPIGAY QVSGEYAMIK FAALAGAIDE EKVVLESLGS
300 IKRAGADLIF SYFALDLAEK KILR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
42447
Li J.-M.,Russell C.S.,Cosloy S.D.
The structure of the Escherichia coli hemB gene.
Gene
75
177-184
1989
42448
Echelard Y.,Dymetryszyn J.,Drolet M.,Sasarman A.
Nucleotide sequence of the hemB gene of Escherichia coli K12.
Mol. Gen. Genet.
214
503-508
1988
42452
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
42453
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
42454
Spencer P.,Jordan P.M.
Purification and characterization of 5-aminolaevulinic acid dehydratase from Escherichia coli and a study of the reactive thiols at the metal-binding domain.
Biochem. J.
290
279-287
1993
42455
Mitchell L.W.,Volin M.,Jaffe E.K.
The phylogenetically conserved histidines of Escherichia coli porphobilinogen synthase are not required for catalysis.
J. Biol. Chem.
270
24054-24059
1995
42456
Erskine P.T.,Norton E.,Cooper J.B.,Lambert R.,Coker A.,Lewis G.,Spencer P.,Sarwar M.,Wood S.P.,Warren M.J.,Shoolingin-Jordan P.M.
X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0-A resolution.
Biochemistry
38
4266-4276
1999
42457
Kervinen J.,Jaffe E.K.,Stauffer F.,Neier R.,Wlodawer A.,Zdanov A.
Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.
Biochemistry
40
8227-8236
2001
42458
Jaffe E.K.,Kervinen J.,Martins J.,Stauffer F.,Neier R.,Wlodawer A.,Zdanov A.
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.
J. Biol. Chem.
277
19792-19799
2002
