Sequence of PEPA5_HUMAN
EC Number:3.4.23.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-/-Val, Gln4-/-His, Glu13-/-Ala, Ala14-/-Leu, Leu15-/-Tyr, Tyr16-/-Leu, Gly23-/-Phe, Phe24-/-Phe and Phe25-/-Tyr bonds in the B chain of insulin
Other sequences found for EC No. 3.4.23.1
General information:
Sequence
0 MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP
60 TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP
120 EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD
180 GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DKSGSVVIFG GIDSSYYTGS
240 LNWVPVTVEG YWQITVDSIT MNGETIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS
300 ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNVPTESGEL
360 WILGDVFIRQ YFTVFDRANN QVGLAPVA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
457458
Evers M.P.J.,Zelle B.,Bebelman J.-P.,van Beusechem V.,Kraakman L.,Hoffer M.J.V.,Pronk J.C.,Mager W.H.,Planta R.J.,Eriksson A.W.,Frants R.R.
Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.
Genomics
4
232-239
1989
457459
Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Nature
440
497-500
2006
457461
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
457462
Ichihara Y.,Sogawa K.,Takahashi K.
Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.
J. Biochem.
98
483-492
1985
457463
Athauda S.B.P.,Tanji M.,Kageyama T.,Takahashi K.
A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.
J. Biochem.
106
920-927
1989
457465
Huang W.-Y.,Tang J.
Carboxyl-terminal sequence of human gastricsin and pepsin.
J. Biol. Chem.
245
2189-2193
1970
457466
Sogawa K.,Fujii-Kuriyama Y.,Mizukami Y.,Ichihara Y.,Takahashi K.
Primary structure of human pepsinogen gene.
J. Biol. Chem.
258
5306-5311
1983
457467
Fujinaga M.,Chernaia M.M.,Tarasova N.I.,Mosimann S.C.,James M.N.G.
Crystal structure of human pepsin and its complex with pepstatin.
Protein Sci.
4
960-972
1995
