Sequence of PK4_PLABA
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
A0A509AMC3
Plasmodium berghei (strain Anka)
2591
306873
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
General information:
Sequence
0 MYNKGINICL NEDNKCIILL HIIFNKCIVS FVASHILVEG KICFLNRIKN SKIFRRFGNI
60 NNHRRNNVKE YYKFVGRINK GKEKRNKCRI KLHRFYEYAK SYILKQIKWV LNKSKYIYFN
120 IIYHLKTICY LKNAFFLQYT QRKYFSQNIE NYIINSLPKH IQSFNPIKWS YYNNNEYASN
180 YIIINNLNFI KYKNKYEKQY DIEMEEDINC KGANDIFYNS YNYCNNNNSN SKCDEKIEKN
240 IVDKNIENKY NIKEYDKTNK SILFPIEEEF KKIIQIENNI ERNYMVPNES NKNILYNIKN
300 ILEKIRNIEA ISNINNYIDM KNTIESYKLN PDKCKEILHK DKDFRNKSKL CLSCFHNIIH
360 KIIYYSKMEN ISFSDMYKQL LTNYNNTSCE YCNLINNSIN SNNDFLSLYN DKNMYNWKNC
420 EKNKFETLEN EISCWNFNSS YGNHFQHIQK NSKIYRRILN EENEKAFNNI VGRNEMENDE
480 LYKRIHTENN YANQFTENNV DFGVYSDLRE YNNGNEKYML DENEMDQIID EEVKKQEKNQ
540 NLNNMDFNNV NKKYNQLKDD NIIIFNKNNM HNNLYSNGLN DSNLEKNNIL FPYEKYNNLD
600 KNEMNLTKYS QNKQFYGQYK YDEAIYKYDL IVLDTSGYIY KVSTDGTYHW KYRIVKNIQY
660 YINYEEENKI ENYYNAFKKN NGKINMTHKD ILRKNDYEQY HKLKLRAMKK LQYNNFIDVF
720 NSNYKKNYPT YLNEQITEKD DIYKKKNYNY EKSKKKSKNK NAMKKLLSDY SGDLFYVDEN
780 NEAIPININI KDVVNNSPFK STLFPNILFI GSRQSSIVNL DFDTGYVIKK YEENYDDLVK
840 EKQKALPNKY EKFINKNSNV LHDKLEKYLD HSIDINDKNY YVNEEKDDLD KDYTIIDGKV
900 AENNQQLDNI DLYNNEIETE NNNGINHLLL IDGKGQIEEQ SPNNGNKIIK GDVSNMTDEC
960 GTENCLSKHS KEEIEIANNK FNKNNKDKLL IQRTKIKNKK HFLMGKWYMN ISNNNLLNIN
1020 SSVLGINKKK RNSKKGENRN KKRKTQKRQL QISLVKWVIK AVDETSLKQK WITSWVDVGS
1080 IFITDSHKQD LSFINSLIDI DGNKLILRTL ENNKVNKPYN NTISKNIEDA ERNELEFASE
1140 NYKNDIPNEI DEHNNKMGRN MNKLNSNIKS KIFIFSKEIS SVFALQYKSK TNIFTLDTIL
1200 KQNEKLFPEY DNIKPYSYNL LNLKNNSNAL LLPFSSSNDY LKNNDKKNLP WNFNYDENGT
1260 NANNSIAFQN YNNFIVQRLN NISINITSIE KDLRYLLLSI IFVFDKHKKI PMNYIFQMKT
1320 LLHEYQKTKQ KFMICLRGLN HNKNINIFSN HNDIRDTDIK HYGYNDYDYI NKEMDAIDEP
1380 IHICEYTNKF IDLSFEGKEK CIDYCSMLNI WDKIFNNYTN HDDCLLLSNL YRILNSTYPL
1440 TNKDFNRIID GIFLKNNESM LIKRRRKPNE GSRNHDLTEF SSQKHKKSWY WNIFYAITLV
1500 IVIPFIFIYR LFKKQTNNKN NNKIIMRKKK ITDYDEDSND TYDDELLNID KVLLKRNKRK
1560 LANILKENGI SSLNKTELEK YMKKSLKKAQ DIEQLTLVDI LARHARDSDS DSNFYDIHDG
1620 KYNLYPYYYS GQESKYSLPN MHYIDLSKSN SGETNKYDLN GNNLFYMHRR RAASQDVTYK
1680 QSFIVKKRVR SNYKLGNKYN KRNYTDYEKD KKNSSIKERN INEKAFDKSD FINFLKNFNK
1740 KFMKKNPFVD HLMKNNKTDS NNEFNNDNKE KSKYLYNEKY NLNSADEENK SPYAKKYSDE
1800 KKNRSKSSKY IENTQSNNND NTNGNMNVGN HINNDKMNNK GSSARNLSII QTSHIPYDAP
1860 LADFLENGRF TRTFQNISLI GQGGFGSVYK VSHRLEPGSP TYAVKFIYLK VSSLDNVNSR
1920 RYFREIAANR DIYSKHVVRY YTWWCEEPQF LPMDIIPKEI QNTLKKNKDP FKKVCNKNKK
1980 DNDYSSDCTV SSGENNKFDL KNYKKVITKK NSPKLKFYSD NDTPYNKRKN INQKNSFLND
2040 KNLSDNIYII ENNKKKKKKK KKKKKIIYKE KKKGNIGINE DNKYSTFYEQ NNPNNFSSTL
2100 QEYDPFGYGY LSENERDLIV FADNDESNGS GHSKKNDNDE RKSLNNQNGI YNTGGDISKN
2160 GNVIHDDSNM LACQQSDKNS MTIKNTQGTS INGTINRNTI SDETGTQGTN NNPKYSIDYH
2220 IDAIVKPKGE SFTWVEKSPS NKYKKDSLDI INRNRKLIEE KNKKEKGQEK EKYKLKMNGE
2280 LEKKENANKI KYYKKKNVGP EFSIVLLLQM EFCKGFTLRR WLDRSSRSDK PLYFTYGDKN
2340 TNHPLEFDLF KQLIKGLKDI HSTCFIHRDL KPENIFVDLD TYILKIGDLG LVRFIEEKKR
2400 ENDLNNIDNF KDNIYTEINH NTITSQISLK GQMIGTPGYT APEGGALCDE KADIYSAALI
2460 LLELLCPRFN TIMERYKTLN DFRNYYTVPD YVKIHLNPWY ILMLQMSKPN PADRPSAADL
2520 YNKIKVLLDP HLTDFTFSFN DINNDDLEYT GNRNVINSTN PNGDIKENVN QNNLVDDKGN
2580 NNIINGNEVD H
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
12438
Otto T.D.,Bohme U.,Jackson A.P.,Hunt M.,Franke-Fayard B.,Hoeijmakers W.A.,Religa A.A.,Robertson L.,Sanders M.,Ogun S.A.,Cunningham D.,Erhart A.,Billker O.,Khan S.M.,Stunnenberg H.G.,Langhorne J.,Holder A.A.,Waters A.P.,Newbold C.I.,Pain A.,Berriman M.,Janse C.J.
A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
BMC Biol.
12
86-86
2014
12439
Zhang M.,Fennell C.,Ranford-Cartwright L.,Sakthivel R.,Gueirard P.,Meister S.,Caspi A.,Doerig C.,Nussenzweig R.S.,Tuteja R.,Sullivan W.J. Jr.,Roos D.S.,Fontoura B.M.,Menard R.,Winzeler E.A.,Nussenzweig V.
The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.
J. Exp. Med.
207
1465-1474
2010
12440
Zhang M.,Mishra S.,Sakthivel R.,Rojas M.,Ranjan R.,Sullivan W.J. Jr.,Fontoura B.M.,Menard R.,Dever T.E.,Nussenzweig V.
PK4, a eukaryotic initiation factor 2alpha(eIF2alpha) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.
Proc. Natl. Acad. Sci. U.S.A.
109
3956-3961
2012
12441
Zhang M.,Gallego-Delgado J.,Fernandez-Arias C.,Waters N.C.,Rodriguez A.,Tsuji M.,Wek R.C.,Nussenzweig V.,Sullivan W.J. Jr.
Inhibiting the Plasmodium eIF2alpha Kinase PK4 Prevents Artemisinin-Induced Latency.
Cell Host Microbe
22
766-776.e4
2017
