Sequence of OAS2_MOUSE
EC Number:2.7.7.84
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
Other sequences found for EC No. 2.7.7.84
General information:
Sequence
0 MGNWLTGNWS SDRSSGYSSG WSPGGSSGVP SGPVHKLEKS IQANLTPNEN CLKQIAVSSV
60 PSQKLEGYIQ ENLKPNRESL KQIDQAVDAI WDLLRSQIPV KEVAKGGSYG RETALRGCSD
120 GTLVLFMDCF QQFQDQIKYQ DAYLDVIELW LKIHEKKSVK HEHALVVQVS VPGQRILLQL
180 LPVFNPLRSN ENPSSCVYVD LKKSMDQVRA SPGEFSDCFT TLQQRFFKKY PQRLKDLILL
240 VKHWYEQCQE KWKTPPPQPL LYALELLTVY AWEQGCQAED FDMAQGVRTV LRLIQRPTEL
300 CVYWTVNYNF EDETVRNILL HQLRSQRPVI LDPTDPTNNV GKDDGFWELL TEEAMAWLYS
360 PSLNTESPAP YWDVLPMPLF VTPSHLLNKF IKDFLQPNKL FLKQIKEAVD IICSFLKNVC
420 FLNSDTKVLK TVKGGSTAKG TALKRGSDAD IVVFLSSLES YDSLKTNRSQ FVQEIQKQLE
480 EFVQAQEWEV TFEISKWKAP RVLSFTLKSK TLNESVEFDV LPAYDALGQL RSDFTLRPEA
540 YKDLIELCAS QDIKEGEFSI CFTELQRNFI QTRPTKLKSL LRLIKHWYKQ YERKMKPKAS
600 LPPKYALELL TVYAWEQGSG TDDFDIAEGF RTVLDLVIKY RQLCIFWTVN YNFEEEYMRK
660 FLLTQIQKKR PVILDPADPT GDVGGGDRWC WHLLAEEAKE WLSSPCFQVE QKGLVQPWKV
720 PVMQTPGSCG GQIYPTVGGV TK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
453354
Kakuta S.,Shibata S.,Iwakura Y.
Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.
J. Interferon Cytokine Res.
22
981-993
2002
453355
Perelygin A.A.,Scherbik S.V.,Zhulin I.B.,Stockman B.M.,Li Y.,Brinton M.A.
Positional cloning of the murine flavivirus resistance gene.
Proc. Natl. Acad. Sci. U.S.A.
99
9322-9327
2002
453356
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
453358
Perelygin A.A.,Zharkikh A.A.,Scherbik S.V.,Brinton M.A.
The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.
J. Mol. Evol.
63
562-576
2006
453359
Sarkar S.N.,Kessler S.P.,Rowe T.M.,Pandey M.,Ghosh A.,Elco C.P.,Hartmann R.,Pal S.,Sen G.C.
Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity.
Biochemistry
44
6837-6843
2005
453360
Kristiansen H.,Gad H.H.,Eskildsen-Larsen S.,Despres P.,Hartmann R.
The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
J. Interferon Cytokine Res.
31
41-47
2011
453361
Oakes S.R.,Gallego-Ortega D.,Stanford P.M.,Junankar S.,Au W.W.Y.,Kikhtyak Z.,von Korff A.,Sergio C.M.,Law A.M.K.,Castillo L.E.,Allerdice S.L.,Young A.I.J.,Piggin C.,Whittle B.,Bertram E.,Naylor M.J.,Roden D.L.,Donovan J.,Korennykh A.,Goodnow C.C.,O'Bryan M.K.,Ormandy C.J.
A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.
PLoS Genet.
13
0-0
2017
