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Sequence of OAS1_HUMAN

EC Number:2.7.7.84

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2'-5' oligoadenylate synthase
P00973
Homo sapiens
400
46029
Reaction
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
Other sequences found for EC No. 2.7.7.84

General information:

Sequence
show sequence in fasta format
  0 MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK
 60 GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE
120 VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GGYKPNPQIY VKLIEECTDL
180 QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW
240 ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD
300 PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN SADDETDDPR
360 RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
453299
Benech P.,Mory Y.,Revel M.,Chebath J.
Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.
EMBO J.
4
2249-2256
1985
453300
Wathelet M.G.,Moutschen S.,Cravador A.,Dewit L.,Defilippi P.,Huez G.A.,Content J.
Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.
FEBS Lett.
196
113-120
1986
453301
Shiojiri S.,Fukunaga R.,Ichii Y.,Sokawa Y.
Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase.
J. Biochem.
99
1455-1464
1986
453302
Ghosh S.K.,Kusari J.,Bandyopadhyay S.K.,Samanta H.,Kumar R.,Sen G.C.
Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.
J. Biol. Chem.
266
15293-15299
1991
453304
Perelygin A.A.,Zharkikh A.A.,Scherbik S.V.,Brinton M.A.
The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.
J. Mol. Evol.
63
562-576
2006
453306
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
453309
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
453310
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
453311
Wathelet M.G.,Clauss I.M.,Nols C.B.,Content J.,Huez G.A.
New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.
Eur. J. Biochem.
169
313-321
1987
453312
Benech P.,Vigneron M.,Peretz D.,Revel M.,Chebath J.
Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.
Mol. Cell. Biol.
7
4498-4504
1987
453313
Rutherford M.N.,Hannigan G.E.,Williams B.R.G.
Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.
EMBO J.
7
751-759
1988
453314
Saunders M.E.,Gewert D.R.,Tugwell M.E.,McMahon M.,Williams B.R.G.
Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.
EMBO J.
4
1761-1768
1985
453315
Merlin G.,Chebath J.,Benech P.,Metz R.,Revel M.
Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.
Proc. Natl. Acad. Sci. U.S.A.
80
4904-4908
1983
453316
Ghosh A.,Sarkar S.N.,Guo W.,Bandyopadhyay S.,Sen G.C.
Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.
J. Biol. Chem.
272
33220-33226
1997
453317
Sarkar S.N.,Ghosh A.,Wang H.W.,Sung S.S.,Sen G.C.
The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.
J. Biol. Chem.
274
25535-25542
1999
453318
Eskildsen S.,Justesen J.,Schierup M.H.,Hartmann R.
Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.
Nucleic Acids Res.
31
3166-3173
2003
453319
Hovanessian A.G.,Justesen J.
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
Biochimie
89
779-788
2007
453320
Marques J.,Anwar J.,Eskildsen-Larsen S.,Rebouillat D.,Paludan S.R.,Sen G.,Williams B.R.,Hartmann R.
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.
J. Gen. Virol.
89
2767-2772
2008
453321
Lin R.J.,Yu H.P.,Chang B.L.,Tang W.C.,Liao C.L.,Lin Y.L.
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
J. Immunol.
183
8035-8043
2009
453322
Melchjorsen J.,Kristiansen H.,Christiansen R.,Rintahaka J.,Matikainen S.,Paludan S.R.,Hartmann R.
Differential regulation of the OASL and OAS1 genes in response to viral infections.
J. Interferon Cytokine Res.
29
199-207
2009
453323
Kjaer K.H.,Poulsen J.B.,Reintamm T.,Saby E.,Martensen P.M.,Kelve M.,Justesen J.
Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.
J. Mol. Evol.
69
612-624
2009
453324
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
453325
Kristiansen H.,Gad H.H.,Eskildsen-Larsen S.,Despres P.,Hartmann R.
The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
J. Interferon Cytokine Res.
31
41-47
2011
453326
Donovan J.,Whitney G.,Rath S.,Korennykh A.
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
Proc. Natl. Acad. Sci. U.S.A.
112
3949-3954
2015
453327
Zhou S.,Butler-Laporte G.,Nakanishi T.,Morrison D.R.,Afilalo J.,Afilalo M.,Laurent L.,Pietzner M.,Kerrison N.,Zhao K.,Brunet-Ratnasingham E.,Henry D.,Kimchi N.,Afrasiabi Z.,Rezk N.,Bouab M.,Petitjean L.,Guzman C.,Xue X.,Tselios C.,Vulesevic B.,Adeleye O.,Abdullah T.,Almamlouk N.,Chen Y.,Chasse M.,Durand M.,Paterson C.,Normark J.,Frithiof R.,Lipcsey M.,Hultstroem M.,Greenwood C.M.T.,Zeberg H.,Langenberg C.,Thysell E.,Pollak M.,Mooser V.,Forgetta V.,Kaufmann D.E.,Richards J.B.
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Nat. Med.
27
659-667
2021
453328
Wickenhagen A.,Sugrue E.,Lytras S.,Kuchi S.,Noerenberg M.,Turnbull M.L.,Loney C.,Herder V.,Allan J.,Jarmson I.,Cameron-Ruiz N.,Varjak M.,Pinto R.M.,Lee J.Y.,Iselin L.,Palmalux N.,Stewart D.G.,Swingler S.,Greenwood E.J.D.,Crozier T.W.M.,Gu Q.,Davies E.L.,Clohisey S.,Wang B.,Trindade Maranhao Costa F.,Freire Santana M.,de Lima Ferreira L.C.,Murphy L.,Fawkes A.,Meynert A.,Grimes G.,Da Silva Filho J.L.,Marti M.,Hughes J.,Stanton R.J.,Wang E.C.Y.,Ho A.,Davis I.,Jarrett R.F.,Castello A.,Robertson D.L.,Semple M.G.,Openshaw P.J.M.,Palmarini M.,Lehner P.J.,Baillie J.K.,Rihn S.J.,Wilson S.J.
A prenylated dsRNA sensor protects against severe COVID-19.
Science
374
0-0
2021
453329
Donovan J.,Dufner M.,Korennykh A.
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.
Proc. Natl. Acad. Sci. U.S.A.
110
1652-1657
2013