Sequence of PDE10_RAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
3',5'-cyclic-nucleotide phosphodiesterase
Q9QYJ6
Rattus norvegicus
794
90161
Reaction
nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MEDGPSNNAS CFRRLTECFL SPSLTDEKVK AYLSLHPQVL DEFVSESVSA ETVEKWLKRK
 60 NNKAEDEPSP KEVSRYQDTN MQGVVYELNS YIEQRLDTGG DNHLLLYELS SIIRIATKAD
120 GFALYFLGEC NNSLCVFTPP GMKEGQPRLI PAGPITQGTT ISAYVAKSRK TLLVEDILGD
180 ERFPRGTGLE SGTRIQSVLC LPIVTAIGDL IGILELYRHW GKEAFCLSHQ EVATANLAWA
240 SVAIHQVQVC RGLAKQTELN DFLLDVSKTY FDNIVAIDSL LEHIMIYAKN LVNADRCALF
300 QVDHKNKELY SDLFDIGEEK EGKPVFKKTK EIRFSIEKGI AGQVARTGEV LNIPDAYADP
360 RFNREVDLYT GYTTRNILCM PIVSRGSVIG VVQMVNKISG SAFSKTDENN FKMFAVFCAL
420 ALHCANMYHR IRHSECIYRV TMEKLSYHSI CTSEEWQGLM HFNLPARICR DIELFHFDIG
480 PFENMWPGIF VYMIHRSCGT SCFELEKLCR FIMSVKKNYR RVPYHNWKHA VTVAHCMYAI
540 LQNNNGLFTD LERKGLLIAC LCHDLDHRGF SNSYLQKFDH PLAALYSTST MEQHHFSQTV
600 SILQLEGHNI FSTLSSSEYE QVLEIIRKAI IATDLALYFG NRKQLEEMYQ TGSLNLHNQS
660 HRDRVIGLMM TACDLCSVTK LWPVTKLTAN DIYAEFWAEG DEMKKLGIQP IPMMDRDKRD
720 EVPQGQLGFY NAVAIPCYTT LTQILPPTEP LLKACRDNLN QWEKVIRGEE TAMWISGPAT
780 SKSTSEKPTR KVDD
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
440754
Fujishige K.,Kotera J.,Omori K.
Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A.
Eur. J. Biochem.
266
1118-1127
1999
440755
O'Connor V.,Genin A.,Davis S.,Karishma K.K.,Doyere V.,De Zeeuw C.I.,Sanger G.,Hunt S.P.,Richter-Levin G.,Mallet J.,Laroche S.,Bliss T.V.P.,French P.J.
Differential amplification of intron-containing transcripts reveals long term potentiation-associated up-regulation of specific Pde10A phosphodiesterase splice variants.
J. Biol. Chem.
279
15841-15849
2004
440757
Chappie T.A.,Humphrey J.M.,Allen M.P.,Estep K.G.,Fox C.B.,Lebel L.A.,Liras S.,Marr E.S.,Menniti F.S.,Pandit J.,Schmidt C.J.,Tu M.,Williams R.D.,Yang F.V.
Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.
J. Med. Chem.
50
182-185
2007