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Sequence of GSK3A_HUMAN

EC Number:2.7.11.26

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tau-protein kinase
P49840
Homo sapiens
483
50981
Reaction
ATP + tau-protein = ADP + O-phospho-tau-protein
Other sequences found for EC No. 2.7.11.26

General information:

Sequence
show sequence in fasta format
  0 MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV
 60 GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT
120 DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY
180 SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV
240 CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS
300 IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK
360 AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP
420 PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT
480 NSS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
40680
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
40681
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
40682
Nikoulina S.E.,Ciaraldi T.P.,Mudaliar S.,Mohideen P.,Carter L.,Henry R.R.
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes
49
263-271
2000
40683
Phiel C.J.,Wilson C.A.,Lee V.M.,Klein P.S.
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Nature
423
435-439
2003
40684
Asuni A.A.,Hooper C.,Reynolds C.H.,Lovestone S.,Anderton B.H.,Killick R.
GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.
Eur. J. Neurosci.
24
3387-3392
2006
40685
Ali A.,Hoeflich K.P.,Woodgett J.R.
Glycogen synthase kinase-3: properties, functions, and regulation.
Chem. Rev.
101
2527-2540
2001
40686
Lee J.,Kim M.S.
The role of GSK3 in glucose homeostasis and the development of insulin resistance.
Diabetes Res. Clin. Pract.
77
0-0
2007
40687
Sun M.,Song L.,Li Y.,Zhou T.,Jope R.S.
Identification of an antiapoptotic protein complex at death receptors.
Cell Death Differ.
15
1887-1900
2008
40688
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
40689
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
40690
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
40691
Rayasam G.V.,Tulasi V.K.,Sodhi R.,Davis J.A.,Ray A.
Glycogen synthase kinase 3: more than a namesake.
Br. J. Pharmacol.
156
885-898
2009
40692
Oh M.,Kim H.,Yang I.,Park J.H.,Cong W.T.,Baek M.C.,Bareiss S.,Ki H.,Lu Q.,No J.,Kwon I.,Choi J.K.,Kim K.
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
J. Biol. Chem.
284
28579-28589
2009
40693
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
40694
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
40695
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
40696
Lin S.Y.,Li T.Y.,Liu Q.,Zhang C.,Li X.,Chen Y.,Zhang S.M.,Lian G.,Liu Q.,Ruan K.,Wang Z.,Zhang C.S.,Chien K.Y.,Wu J.,Li Q.,Han J.,Lin S.C.
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Science
336
477-481
2012
40697
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
40698
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
40699
Poirier V.,Bach H.,Av-Gay Y.
Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3alpha.
J. Biol. Chem.
289
29376-29385
2014
40700
Koo J.,Wu X.,Mao Z.,Khuri F.R.,Sun S.Y.
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
J. Biol. Chem.
290
14120-14129
2015
40701
Cheng X.,Ma X.,Zhu Q.,Song D.,Ding X.,Li L.,Jiang X.,Wang X.,Tian R.,Su H.,Shen Z.,Chen S.,Liu T.,Gong W.,Liu W.,Sun Q.
Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism.
Mol. Cell
73
1-15
2019
40702
Choi J.H.,Zhong X.,McAlpine W.,Liao T.C.,Zhang D.,Fang B.,Russell J.,Ludwig S.,Nair-Gill E.,Zhang Z.,Wang K.W.,Misawa T.,Zhan X.,Choi M.,Wang T.,Li X.,Tang M.,Sun Q.,Yu L.,Murray A.R.,Moresco E.M.Y.,Beutler B.
LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.
Science
364
0-0
2019
40703
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007