Sequence of LCB2_YEAST

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
serine C-palmitoyltransferase
P40970
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
561
63111
Reaction
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSTPANYTRV PLCEPEELPD DIQKENEYGT LDSPGHLYQV KSRHGKPLPE PVVDTPPYYI
 60 SLLTYLNYLI LIILGHVHDF LGMTFQKNKH LDLLEHDGLA PWFSNFESFY VRRIKMRIDD
120 CFSRPTTGVP GRFIRCIDRI SHNINEYFTY SGAVYPCMNL SSYNYLGFAQ SKGQCTDAAL
180 ESVDKYSIQS GGPRAQIGTT DLHIKAEKLV ARFIGKEDAL VFSMGYGTNA NLFNAFLDKK
240 CLVISDELNH TSIRTGVRLS GAAVRTFKHG DMVGLEKLIR EQIVLGQPKT NRPWKKILIC
300 AEGLFSMEGT LCNLPKLVEL KKKYKCYLFI DEAHSIGAMG PTGRGVCEIF GVDPKDVDIL
360 MGTFTKSFGA AGGYIAADQW IIDRLRLDLT TVSYSESMPA PVLAQTISSL QTISGEICPG
420 QGTERLQRIA FNSRYLRLAL QRLGFIVYGV ADSPVIPLLL YCPSKMPAFS RMMLQRRIAV
480 VVVAYPATPL IESRVRFCMS ASLTKEDIDY LLRHVSEVGD KLNLKSNSGK SSYDGKRQRW
540 DIEEVIRRTP EDCKDDKYFV N
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
431369
Zhao C.,Beeler T.,Dunn T.
Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity.
J. Biol. Chem.
269
21480-21488
1994
431370
Nagiec M.M.,Baltisberger J.A.,Wells G.B.,Lester R.L.,Dickson R.C.
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.
Proc. Natl. Acad. Sci. U.S.A.
91
7899-7902
1994
431371
Brandt P.,Ramlow S.,Otto B.,Bloecker H.
Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV.
Yeast
12
85-90
1996
431372
Jacq C.,Alt-Moerbe J.,Andre B.,Arnold W.,Bahr A.,Ballesta J.P.G.,Bargues M.,Baron L.,Becker A.,Biteau N.,Bloecker H.,Blugeon C.,Boskovic J.,Brandt P.,Brueckner M.,Buitrago M.J.,Coster F.,Delaveau T.,del Rey F.,Dujon B.,Eide L.G.,Garcia-Cantalejo J.M.,Goffeau A.,Gomez-Peris A.,Granotier C.,Hanemann V.,Hankeln T.,Hoheisel J.D.,Jaeger W.,Jimenez A.,Jonniaux J.-L.,Kraemer C.,Kuester H.,Laamanen P.,Legros Y.,Louis E.J.,Moeller-Rieker S.,Monnet A.,Moro M.,Mueller-Auer S.,Nussbaumer B.,Paricio N.,Paulin L.,Perea J.,Perez-Alonso M.,Perez-Ortin J.E.,Pohl T.M.,Prydz H.,Purnelle B.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Rieger M.,Salom D.,Saluz H.P.,Saiz J.E.,Saren A.-M.,Schaefer M.,Scharfe M.,Schmidt E.R.,Schneider C.,Scholler P.,Schwarz S.,Soler-Mira A.,Urrestarazu L.A.,Verhasselt P.,Vissers S.,Voet M.,Volckaert G.,Wagner G.,Wambutt R.,Wedler E.,Wedler H.,Woelfl S.,Harris D.E.,Bowman S.,Brown D.,Churcher C.M.,Connor R.,Dedman K.,Gentles S.,Hamlin N.,Hunt S.,Jones L.,McDonald S.,Murphy L.D.,Niblett D.,Odell C.,Oliver K.,Rajandream M.A.,Richards C.,Shore L.,Walsh S.V.,Barrell B.G.,Dietrich F.S.,Mulligan J.T.,Allen E.,Araujo R.,Aviles E.,Berno A.,Carpenter J.,Chen E.,Cherry J.M.,Chung E.,Duncan M.,Hunicke-Smith S.,Hyman R.W.,Komp C.,Lashkari D.,Lew H.,Lin D.,Mosedale D.,Nakahara K.,Namath A.,Oefner P.,Oh C.,Petel F.X.,Roberts D.,Schramm S.,Schroeder M.,Shogren T.,Shroff N.,Winant A.,Yelton M.A.,Botstein D.,Davis R.W.,Johnston M.,Andrews S.,Brinkman R.,Cooper J.,Ding H.,Du Z.,Favello A.,Fulton L.,Gattung S.,Greco T.,Hallsworth K.,Hawkins J.,Hillier L.W.,Jier M.,Johnson D.,Johnston L.,Kirsten J.,Kucaba T.,Langston Y.,Latreille P.,Le T.,Mardis E.,Menezes S.,Miller N.,Nhan M.,Pauley A.,Peluso D.,Rifkin L.,Riles L.,Taich A.,Trevaskis E.,Vignati D.,Wilcox L.,Wohldman P.,Vaudin M.,Wilson R.,Waterston R.,Albermann K.,Hani J.,Heumann K.,Kleine K.,Mewes H.-W.,Zollner A.,Zaccaria P.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature
387
75-78
1997
431373
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
431374
Hu Y.,Rolfs A.,Bhullar B.,Murthy T.V.S.,Zhu C.,Berger M.F.,Camargo A.A.,Kelley F.,McCarron S.,Jepson D.,Richardson A.,Raphael J.,Moreira D.,Taycher E.,Zuo D.,Mohr S.,Kane M.F.,Williamson J.,Simpson A.J.G.,Bulyk M.L.,Harlow E.,Marsischky G.,Kolodner R.D.,LaBaer J.
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
Genome Res.
17
536-543
2007
431375
Gable K.,Slife H.,Bacikova D.,Monaghan E.,Dunn T.M.
Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.
J. Biol. Chem.
275
7597-7603
2000
431376
Gable K.,Han G.,Monaghan E.,Bacikova D.,Natarajan M.,Williams R.,Dunn T.M.
Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.
J. Biol. Chem.
277
10194-10200
2002
431377
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
431378
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
431379
Han G.,Gable K.,Yan L.,Natarajan M.,Krishnamurthy J.,Gupta S.D.,Borovitskaya A.,Harmon J.M.,Dunn T.M.
The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.
J. Biol. Chem.
279
53707-53716
2004
431380
Breslow D.K.,Collins S.R.,Bodenmiller B.,Aebersold R.,Simons K.,Shevchenko A.,Ejsing C.S.,Weissman J.S.
Orm family proteins mediate sphingolipid homeostasis.
Nature
463
1048-1053
2010