Sequence of CARA_PECCC
EC Number:6.3.3.6
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
carbapenam-3-carboxylate synthase
Q9XB61
Pectobacterium carotovorum subsp. carotovorum
503
55998
Reaction
ATP + (2S,5S)-5-carboxymethylproline = AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate
Other sequences found for EC No. 6.3.3.6
General information:
Sequence
0 MSNSFCVVYK GSDTDINNIQ RDFDGKGEAL SNGYLFIEQN GHYQKCEMER GTAYLIGSLY
60 NRTFLIGLAG VWEGEAYLAN DAELLALLFT RLGANALALA EGDFCFFIDE PNGELTVITE
120 SRGFSPVHVV QGKKAWMTNS LKLVTAAEGE GALWFEEEAL VCQSLMRADT YTPVKNAQRL
180 KPGAVHVLTH DSEGYSFVES RTLTTPASNQ LLALPREPLL ALIDRYLNAP LEDLAPRFDT
240 VGIPLSGGLD SSLVTALASR HFKKLNTYSI GTELSNEFEF SQQVADALGT HHQMKILSET
300 EVINGIIESI YYNEIFDGLS AEIQSGLFNV YRQAQGQVSC MLTGYGSDLL FGGILKPGAQ
360 YDNPNQLLAE QVYRTRWTGE FATHGASCYG IDIRHPFWSH SLISLCHALH PDYKIFDNEV
420 KNILREYADS LQLLPKDIVW RKKIGIHEGS SVNQAFANVL GSTVDNYQTK SRFTYRVYQA
480 FLRGRLSITD VTPSQLKDLI KKD
Download this sequence
in fasta formatDownload all sequences for 6.3.3.6
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
398083
McGowan S.J.,Sebaihia M.,O'Leary S.,Hardie K.R.,Williams P.,Stewart G.S.,Bycroft B.W.,Salmond G.P.
Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism.
Mol. Microbiol.
26
545-556
1997
398084
Gerratana B.,Stapon A.,Townsend C.A.
Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora.
Biochemistry
42
7836-7847
2003
398085
Arnett S.O.,Gerratana B.,Townsend C.A.
Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase.
Biochemistry
46
9337-9345
2007
398086
Raber M.L.,Arnett S.O.,Townsend C.A.
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.
Biochemistry
48
4959-4971
2009
398087
Miller M.T.,Gerratana B.,Stapon A.,Townsend C.A.,Rosenzweig A.C.
Crystal structure of carbapenam synthetase (CarA).
J. Biol. Chem.
278
40996-41002
2003
