Sequence of CAH2_HUMAN

cyanamide hydratase

P00918

260

29246

397376

Montgomery J.C.,Venta P.J.,Tashian R.E.,Hewett-Emmett D.

Nucleotide sequence of human liver carbonic anhydrase II cDNA.

Nucleic Acids Res.

15

4687-4687

1987

397377

Murakami H.,Marelich G.P.,Grubb J.H.,Kyle J.W.,Sly W.S.

Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II.

Genomics

1

159-166

1987

397379

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

397381

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

397382

Lin K.-T.D.,Deutsch H.F.

Human carbonic anhydrases. XII. The complete primary structure of the C isozyme.

J. Biol. Chem.

249

2329-2337

1974

397383

Henderson L.E.,Henriksson D.,Nyman P.O.

Primary structure of human carbonic anhydrase C.

J. Biol. Chem.

251

5457-5463

1976

397384

Venta P.J.,Montgomery J.C.,Hewett-Emmett D.,Tashian R.E.

Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements.

Biochim. Biophys. Acta

826

195-201

1985

397385

Alvarez B.V.,Loiselle F.B.,Supuran C.T.,Schwartz G.J.,Casey J.R.

Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter.

Biochemistry

42

12321-12329

2003

397386

Loiselle F.B.,Morgan P.E.,Alvarez B.V.,Casey J.R.

Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.

Am. J. Physiol.

286

0-0

2004

397387

Pushkin A.,Abuladze N.,Gross E.,Newman D.,Tatishchev S.,Lee I.,Fedotoff O.,Bondar G.,Azimov R.,Ngyuen M.,Kurtz I.

Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells.

J. Physiol. (Lond.)

559

55-65

2004

397388

Alvarez B.V.,Vilas G.L.,Casey J.R.

Metabolon disruption: a mechanism that regulates bicarbonate transport.

EMBO J.

24

2499-2511

2005

397389

Temperini C.,Innocenti A.,Guerri A.,Scozzafava A.,Rusconi S.,Supuran C.T.

Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

Bioorg. Med. Chem. Lett.

17

2210-2215

2007

397390

Di Fiore A.,Monti S.M.,Hilvo M.,Parkkila S.,Romano V.,Scaloni A.,Pedone C.,Scozzafava A.,Supuran C.T.,De Simone G.

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

Proteins

74

164-175

2009

397391

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

397392

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

397393

Liljas A.,Kannan K.K.,Bergsten P.-C.,Waara I.,Fridborg K.,Strandberg B.,Carlbom U.,Jaerup L.,Loevgren S.,Petef M.

Crystal structure of human carbonic anhydrase C.

Nature New Biol.

235

131-137

1972

397394

Eriksson A.E.,Jones T.A.,Liljas A.

Refined structure of human carbonic anhydrase II at 2.0-A resolution.

Proteins

4

274-282

1988

397395

Eriksson A.E.,Kylsten P.M.,Jones T.A.,Liljas A.

Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN-ion to the zinc at high pH.

Proteins

4

283-293

1988

397396

Krebs J.F.,Fierke C.A.,Alexander R.S.,Christianson D.W.

Conformational mobility of His-64 in the Thr-200TO: human carbonic anhydrase II.

Biochemistry

30

9153-9160

1991

397397

Alexander R.S.,Nair S.K.,Christianson D.W.

Engineering the hydrophobic pocket of carbonic anhydrase II.

Biochemistry

30

11064-11072

1991

397398

Nair S.K.,Calderone T.L.,Christianson D.W.,Fierke C.A.

Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.

J. Biol. Chem.

266

17320-17325

1991

397399

Mangani S.,Haakansson K.

Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.

Eur. J. Biochem.

210

867-871

1992

397400

Haakansson K.,Carlsson M.,Svensson L.A.,Liljas A.

Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.

J. Mol. Biol.

227

1192-1204

1992

397401

Haakansson K.,Wehnert A.

Structure of cobalt carbonic anhydrase complexed with bicarbonate.

J. Mol. Biol.

228

1212-1218

1992

397402

Alexander R.S.,Kiefer L.L.,Fierke C.A.,Christianson D.W.

Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.

Biochemistry

32

1510-1518

1993

397403

Nair S.K.,Christianson D.W.

Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.

Biochemistry

32

4506-4514

1993

397404

Ippolito J.A.,Christianson D.W.

Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.

Biochemistry

32

9901-9905

1993

397405

Tweedy N.B.,Nair S.K.,Paterno S.A.,Fierke C.A.,Christianson D.W.

Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.

Biochemistry

32

10944-10949

1993

397406

Joensson B.M.,Haakansson K.,Liljas A.

The structure of human carbonic anhydrase II in complex with bromide and azide.

FEBS Lett.

322

186-190

1993

397407

Krebs J.F.,Ippolito J.A.,Christianson D.W.,Fierke C.A.

Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.

J. Biol. Chem.

268

27458-27466

1993

397408

Mangani S.,Liljas A.

Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole.

J. Mol. Biol.

232

9-14

1993

397409

Xue Y.,Vidgren J.,Svensson L.A.,Liljas A.,Jonsson B.H.,Lindskog S.

Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-.

Proteins

15

80-87

1993

397410

Xue Y.,Liljas A.,Jonsson B.H.,Lindskog S.

Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.

Proteins

17

93-106

1993

397411

Haakansson K.,Wehnert A.,Liljas A.

X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.

Acta Crystallogr. D

50

93-100

1994

397412

Haakansson K.,Briand C.,Zaitsev V.,Xue Y.,Liljas A.

Wild-type and E106Q mutant carbonic anhydrase complexed with acetate.

Acta Crystallogr. D

50

101-104

1994

397413

Ippolito J.A.,Christianson D.W.

Structural consequences of redesigning a protein-zinc binding site.

Biochemistry

33

15241-15249

1994

397414

Haakansson K.,Liljas A.

The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide.

FEBS Lett.

350

319-322

1994

397415

Smith G.M.,Alexander R.S.,Christianson D.W.,McKeever B.M.,Ponticello G.S.,Springer J.P.,Randall W.C.,Baldwin J.J.,Habecker C.N.

Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.

Protein Sci.

3

118-125

1994

397416

Nair S.K.,Krebs J.F.,Christianson D.W.,Fierke C.A.

Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.

Biochemistry

34

3981-3989

1995

397417

Boriack P.A.,Christianson D.W.,Kingery-Wood J.,Whitesides G.M.

Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.

J. Med. Chem.

38

2286-2291

1995

397418

Ippolito J.A.,Baird T.T. Jr.,McGee S.A.,Christianson D.W.,Fierke C.A.

Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.

Proc. Natl. Acad. Sci. U.S.A.

92

5017-5021

1995

397419

Huang C.C.,Lesburg C.A.,Kiefer L.L.,Fierke C.A.,Christianson D.W.

Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.

Biochemistry

35

3439-3446

1996

397420

Scolnick L.R.,Christianson D.W.

X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.

Biochemistry

35

16429-16434

1996

397421

Nair S.K.,Elbaum D.,Christianson D.W.

Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor.

J. Biol. Chem.

271

1003-1007

1996

397422

Briganti F.,Mangani S.,Orioli P.,Scozzafava A.,Vernaglione G.,Supuran C.T.

Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.

Biochemistry

36

10384-10392

1997

397423

Lesburg C.A.,Huang C.,Christianson D.W.,Fierke C.A.

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.

Biochemistry

36

15780-15791

1997

397424

Stams T.,Chen Y.,Boriack-Sjodin P.A.,Hurt J.D.,Liao J.,May J.A.,Dean T.,Laipis P.,Silverman D.N.,Christianson D.W.

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.

Protein Sci.

7

556-563

1998

397425

Boriack-Sjodin P.A.,Zeitlin S.,Chen H.H.,Crenshaw L.,Gross S.,Dantanarayana A.,Delgado P.,May J.A.,Dean T.,Christianson D.W.

Structural analysis of inhibitor binding to human carbonic anhydrase II.

Protein Sci.

7

2483-2489

1998

397426

Briganti F.,Mangani S.,Scozzafava A.,Vernaglione G.,Supuran C.T.

Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?

J. Biol. Inorg. Chem.

4

528-536

1999

397427

Guerri A.,Briganti F.,Scozzafava A.,Supuran C.T.,Mangani S.

Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.

Biochemistry

39

12391-12397

2000

397428

Cox J.D.,Hunt J.A.,Compher K.M.,Fierke C.A.,Christianson D.W.

Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.

Biochemistry

39

13687-13694

2000

397429

Duda D.,Tu C.,Qian M.,Laipis P.,Agbandje-McKenna M.,Silverman D.N.,McKenna R.

Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.

Biochemistry

40

1741-1748

2001

397430

Kim C.Y.,Chandra P.P.,Jain A.,Christianson D.W.

Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.

J. Am. Chem. Soc.

123

9620-9627

2001

397431

Recacha R.,Costanzo M.J.,Maryanoff B.E.,Chattopadhyay D.

Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.

Biochem. J.

361

437-441

2002

397432

Huang S.,Sjoeblom B.,Sauer-Eriksson A.E.,Jonsson B.H.

Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.

Biochemistry

41

7628-7635

2002

397433

Tu C.,Qian M.,An H.,Wadhwa N.R.,Duda D.,Yoshioka C.,Pathak Y.,McKenna R.,Laipis P.J.,Silverman D.N.

Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.

J. Biol. Chem.

277

38870-38876

2002

397434

Kim C.Y.,Whittington D.A.,Chang J.S.,Liao J.,May J.A.,Christianson D.W.

Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.

J. Med. Chem.

45

888-893

2002

397435

Grueneberg S.,Stubbs M.T.,Klebe G.

Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.

J. Med. Chem.

45

3588-3602

2002

397436

Grzybowski B.A.,Ishchenko A.V.,Kim C.Y.,Topalov G.,Chapman R.,Christianson D.W.,Whitesides G.M.,Shakhnovich E.I.

Combinatorial computational method gives new picomolar ligands for a known enzyme.

Proc. Natl. Acad. Sci. U.S.A.

99

1270-1273

2002

397437

Duda D.,Govindasamy L.,Agbandje-McKenna M.,Tu C.,Silverman D.N.,McKenna R.

The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.

Acta Crystallogr. D

59

93-104

2003

397438

Weber A.,Casini A.,Heine A.,Kuhn D.,Supuran C.T.,Scozzafava A.,Klebe G.

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

J. Med. Chem.

47

550-557

2004

397439

Lloyd M.D.,Pederick R.L.,Natesh R.,Woo L.W.,Purohit A.,Reed M.J.,Acharya K.R.,Potter B.V.

Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.

Biochem. J.

385

715-720

2005

397440

Fisher Z.,Hernandez Prada J.A.,Tu C.,Duda D.,Yoshioka C.,An H.,Govindasamy L.,Silverman D.N.,McKenna R.

Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.

Biochemistry

44

1097-1105

2005

397441

Lloyd M.D.,Thiyagarajan N.,Ho Y.T.,Woo L.W.,Sutcliffe O.B.,Purohit A.,Reed M.J.,Acharya K.R.,Potter B.V.

First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.

Biochemistry

44

6858-6866

2005

397442

Temperini C.,Scozzafava A.,Puccetti L.,Supuran C.T.

Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.

Bioorg. Med. Chem. Lett.

15

5136-5141

2005

397443

Menchise V.,De Simone G.,Alterio V.,Di Fiore A.,Pedone C.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

J. Med. Chem.

48

5721-5727

2005

397444

Bhatt D.,Tu C.,Fisher S.Z.,Hernandez Prada J.A.,McKenna R.,Silverman D.N.

Proton transfer in a Thr200His mutant of human carbonic anhydrase II.

Proteins

61

239-245

2005

397445

Budayova-Spano M.,Fisher S.Z.,Dauvergne M.T.,Agbandje-McKenna M.,Silverman D.N.,Myles D.A.,McKenna R.

Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.

Acta Crystallogr. F

62

6-9

2006

397446

Fisher S.Z.,Govindasamy L.,Boyle N.,Agbandje-McKenna M.,Silverman D.N.,Blackburn G.M.,McKenna R.

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.

Acta Crystallogr. F

62

618-622

2006

397447

Di Fiore A.,Pedone C.,D'Ambrosio K.,Scozzafava A.,De Simone G.,Supuran C.T.

Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib.

Bioorg. Med. Chem. Lett.

16

437-442

2006

397448

Temperini C.,Innocenti A.,Scozzafava A.,Supuran C.T.

N-hydroxyurea -- a versatile zinc binding function in the design of metalloenzyme inhibitors.

Bioorg. Med. Chem. Lett.

16

4316-4320

2006

397449

Menchise V.,De Simone G.,Di Fiore A.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.

Bioorg. Med. Chem. Lett.

16

6204-6208

2006

397450

Temperini C.,Scozzafava A.,Vullo D.,Supuran C.T.

Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

Chemistry

12

7057-7066

2006

397451

Jude K.M.,Banerjee A.L.,Haldar M.K.,Manokaran S.,Roy B.,Mallik S.,Srivastava D.K.,Christianson D.W.

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity.

J. Am. Chem. Soc.

128

3011-3018

2006

397452

Alterio V.,Vitale R.M.,Monti S.M.,Pedone C.,Scozzafava A.,Cecchi A.,De Simone G.,Supuran C.T.

Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

J. Am. Chem. Soc.

128

8329-8335

2006

397453

Temperini C.,Scozzafava A.,Vullo D.,Supuran C.T.

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.

J. Med. Chem.

49

3019-3027

2006

397454

De Simone G.,Vitale R.M.,Di Fiore A.,Pedone C.,Scozzafava A.,Montero J.-L.,Winum J.-Y.,Supuran C.T.

Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.

J. Med. Chem.

49

5544-5551

2006

397455

Winum J.Y.,Temperini C.,El Cheikh K.,Innocenti A.,Vullo D.,Ciattini S.,Montero J.-L.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.

J. Med. Chem.

49

7024-7031

2006

397456

Leese M.P.,Leblond B.,Smith A.,Newman S.P.,Di Fiore A.,De Simone G.,Supuran C.T.,Purohit A.,Reed M.J.,Potter B.V.

2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.

J. Med. Chem.

49

7683-7696

2006

397457

Koehler K.,Hillebrecht A.,Schulze Wischeler J.,Innocenti A.,Heine A.,Supuran C.T.,Klebe G.

Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

Angew. Chem. Int. Ed. Engl.

46

7697-7699

2007

397458

Fisher S.Z.,Maupin C.M.,Budayova-Spano M.,Govindasamy L.,Tu C.,Agbandje-McKenna M.,Silverman D.N.,Voth G.A.,McKenna R.

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.

Biochemistry

46

2930-2937

2007

397459

Fisher S.Z.,Tu C.,Bhatt D.,Govindasamy L.,Agbandje-McKenna M.,McKenna R.,Silverman D.N.

Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.

Biochemistry

46

3803-3813

2007

397460

Temperini C.,Innocenti A.,Scozzafava A.,Mastrolorenzo A.,Supuran C.T.

Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.

Bioorg. Med. Chem. Lett.

17

628-635

2007

397461

Di Fiore A.,Scozzafava A.,Winum J.-Y.,Montero J.-L.,Pedone C.,Supuran C.T.,De Simone G.

Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.

Bioorg. Med. Chem. Lett.

17

1726-1731

2007

397462

Temperini C.,Winum J.Y.,Montero J.L.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.

Bioorg. Med. Chem. Lett.

17

2795-2801

2007

397463

Alterio V.,De Simone G.,Monti S.M.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides -- solution and crystallographic studies.

Bioorg. Med. Chem. Lett.

17

4201-4207

2007

397464

Temperini C.,Innocenti A.,Mastrolorenzo A.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.

Bioorg. Med. Chem. Lett.

17

4866-4872

2007

397465

Bhatt D.,Fisher S.Z.,Tu C.,McKenna R.,Silverman D.N.

Location of binding sites in small molecule rescue of human carbonic anhydrase II.

Biophys. J.

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2007

397466

Srivastava D.K.,Jude K.M.,Banerjee A.L.,Haldar M.,Manokaran S.,Kooren J.,Mallik S.,Christianson D.W.

Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II.

J. Am. Chem. Soc.

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2007

397467

Barrese A.A. III,Genis C.,Fisher S.Z.,Orwenyo J.N.,Kumara M.T.,Dutta S.K.,Phillips E.,Kiddle J.J.,Tu C.,Silverman D.N.,Govindasamy L.,Agbandje-McKenna M.,McKenna R.,Tripp B.C.

Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.

Biochemistry

47

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2008

397468

Zheng J.,Avvaru B.S.,Tu C.,McKenna R.,Silverman D.N.

Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.

Biochemistry

47

12028-12036

2008

397469

Guezel O.,Temperini C.,Innocenti A.,Scozzafava A.,Salman A.,Supuran C.T.

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Bioorg. Med. Chem. Lett.

18

152-158

2008

397470

Temperini C.,Cecchi A.,Boyle N.A.,Scozzafava A.,Cabeza J.E.,Wentworth P. Jr.,Blackburn G.M.,Supuran C.T.

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Bioorg. Med. Chem. Lett.

18

999-1005

2008

397471

Temperini C.,Cecchi A.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.

Bioorg. Med. Chem. Lett.

18

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2008

397472

Di Fiore A.,Pedone C.,Antel J.,Waldeck H.,Witte A.,Wurl M.,Scozzafava A.,Supuran C.T.,De Simone G.

Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.

Bioorg. Med. Chem. Lett.

18

2669-2674

2008

397473

Temperini C.,Innocenti A.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.

Bioorg. Med. Chem. Lett.

18

4282-4286

2008

397474

D'Ambrosio K.,Masereel B.,Thiry A.,Scozzafava A.,Supuran C.T.,De Simone G.

Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.

ChemMedChem

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473-477

2008

397475

Aaron J.A.,Chambers J.M.,Jude K.M.,Di Costanzo L.,Dmochowski I.J.,Christianson D.W.

Structure of a (129)Xe-cryptophane biosensor complexed with human carbonic anhydrase II.

J. Am. Chem. Soc.

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2008

397476

Domsic J.F.,Avvaru B.S.,Kim C.U.,Gruner S.M.,Agbandje-McKenna M.,Silverman D.N.,McKenna R.

Entrapment of carbon dioxide in the active site of carbonic anhydrase II.

J. Biol. Chem.

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397477

Leese M.P.,Jourdan F.L.,Gaukroger K.,Mahon M.F.,Newman S.P.,Foster P.A.,Stengel C.,Regis-Lydi S.,Ferrandis E.,Di Fiore A.,De Simone G.,Supuran C.T.,Purohit A.,Reed M.J.,Potter B.V.

Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.

J. Med. Chem.

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2008

397478

D'Ambrosio K.,Vitale R.-M.,Dogne J.-M.,Masereel B.,Innocenti A.,Scozzafava A.,De Simone G.,Supuran C.T.

Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.

J. Med. Chem.

51

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2008

397479

Woo L.W.L.,Fischer D.S.,Sharland C.M.,Trusselle M.,Foster P.A.,Chander S.K.,Di Fiore A.,Supuran C.T.,De Simone G.,Purohit A.,Reed M.J.,Potter B.V.L.

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography.

Mol. Cancer Ther.

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2008

397480

Genis C.,Sippel K.H.,Case N.,Cao W.,Avvaru B.S.,Tartaglia L.J.,Govindasamy L.,Tu C.,Agbandje-McKenna M.,Silverman D.N.,Rosser C.J.,McKenna R.

Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Biochemistry

48

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2009

397481

Avvaru B.S.,Busby S.A.,Chalmers M.J.,Griffin P.R.,Venkatakrishnan B.,Agbandje-McKenna M.,Silverman D.N.,McKenna R.

Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.

Biochemistry

48

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2009

397482

Crocetti L.,Maresca A.,Temperini C.,Hall R.A.,Scozzafava A.,Muehlschlegel F.A.,Supuran C.T.

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

Bioorg. Med. Chem. Lett.

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2009

397483

Maresca A.,Temperini C.,Vu H.,Pham N.B.,Poulsen S.-A.,Scozzafava A.,Quinn R.J.,Supuran C.T.

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

J. Am. Chem. Soc.

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2009

397484

Temperini C.,Cecchi A.,Scozzafava A.,Supuran C.T.

Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.

J. Med. Chem.

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Vitale R.M.,Alterio V.,Innocenti A.,Winum J.-Y.,Monti S.M.,De Simone G.,Supuran C.T.

Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.

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397486

Lopez M.,Paul B.,Hofmann A.,Morizzi J.,Wu Q.K.,Charman S.A.,Innocenti A.,Vullo D.,Supuran C.T.,Poulsen S.-A.

S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.

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Ciani L.,Cecchi A.,Temperini C.,Supuran C.T.,Ristori S.

Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR.

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2009

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Sjoeblom B.,Polentarutti M.,Djinovic-Carugo K.

Structural study of X-ray induced activation of carbonic anhydrase.

Proc. Natl. Acad. Sci. U.S.A.

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397489

Jones G.L.,Sofro A.S.M.,Shaw D.C.

Chemical and enzymological characterization of an Indonesian variant of human erythrocyte carbonic anhydrase II, CAII Jogjakarta (17 Lys leads to Glu).

Biochem. Genet.

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Jones G.L.,Shaw D.C.

A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His).

Hum. Genet.

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397491

Venta P.J.,Welty R.J.,Johnson T.M.,Sly W.S.,Tashian R.E.

Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-->Tyr): complete structure of the normal human CA II gene.

Am. J. Hum. Genet.

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Roth D.E.,Venta P.J.,Tashian R.E.,Sly W.S.

Molecular basis of human carbonic anhydrase II deficiency.

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Soda H.,Yukizane S.,Yoshida I.,Koga Y.,Aramaki S.,Kato H.

A point mutation in exon 3 (His 107-->Tyr) in two unrelated Japanese patients with carbonic anhydrase II deficiency with central nervous system involvement.

Hum. Genet.

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Hu P.Y.,Lim E.J.,Ciccolella J.,Strisciuglio P.,Sly W.S.

Seven novel mutations in carbonic anhydrase II deficiency syndrome identified by SSCP and direct sequencing analysis.

Hum. Mutat.

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Shah G.N.,Bonapace G.,Hu P.Y.,Strisciuglio P.,Sly W.S.

Carbonic anhydrase II deficiency syndrome (osteopetrosis with renal tubular acidosis and brain calcification): novel mutations in CA2 identified by direct sequencing expand the opportunity for genotype-phenotype correlation.

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