Sequence of BPHD_PARXL
EC Number:3.7.1.8
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2,6-dioxo-6-phenylhexa-3-enoate hydrolase
P47229
Paraburkholderia xenovorans (strain LB400)
286
32030
Reaction
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate
Other sequences found for EC No. 3.7.1.8
General information:
Sequence
0 MTALTESSTS KFVKINEKGF SDFNIHYNEA GNGETVIMLH GGGPGAGGWS NYYRNVGPFV
60 DAGYRVILKD SPGFNKSDAV VMDEQRGLVN ARAVKGLMDA LDIDRAHLVG NSMGGATALN
120 FALEYPDRIG KLILMGPGGL GPSMFAPMPM EGIKLLFKLY AEPSYETLKQ MLQVFLYDQS
180 LITEELLQGR WEAIQRQPEH LKNFLISAQK APLSTWDVTA RLGEIKAKTF ITWGRDDRFV
240 PLDHGLKLLW NIDDARLHVF SKCGHWAQWE HADEFNRLVI DFLRHA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
395844
Hofer B.,Eltis L.D.,Dowling D.N.,Timmis K.N.
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
Gene
130
47-55
1993
395845
Chain P.S.G.,Denef V.J.,Konstantinidis K.T.,Vergez L.M.,Agullo L.,Reyes V.L.,Hauser L.,Cordova M.,Gomez L.,Gonzalez M.,Land M.,Lao V.,Larimer F.,LiPuma J.J.,Mahenthiralingam E.,Malfatti S.A.,Marx C.J.,Parnell J.J.,Ramette A.,Richardson P.,Seeger M.,Smith D.,Spilker T.,Sul W.J.,Tsoi T.V.,Ulrich L.E.,Zhulin I.B.,Tiedje J.M.
Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility.
Proc. Natl. Acad. Sci. U.S.A.
103
15280-15287
2006
395846
Horsman G.P.,Ke J.,Dai S.,Seah S.Y.K.,Bolin J.T.,Eltis L.D.
Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.
Biochemistry
45
11071-11086
2006
395847
Horsman G.P.,Bhowmik S.,Seah S.Y.,Kumar P.,Bolin J.T.,Eltis L.D.
The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad.
J. Biol. Chem.
282
19894-19904
2007
395848
Bhowmik S.,Horsman G.P.,Bolin J.T.,Eltis L.D.
The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization.
J. Biol. Chem.
282
36377-36385
2007
