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Sequence of GLFT2_MYCTU

EC Number:2.4.1.288

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase
O53585
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
637
71507
Reaction
28 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 28 UDP + [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
Other sequences found for EC No. 2.4.1.288

General information:

Sequence
show sequence in fasta format
  0 MSELAASLLS RVILPRPGEP LDVRKLYLEE STTNARRAHA PTRTSLQIGA ESEVSFATYF
 60 NAFPASYWRR WTTCKSVVLR VQVTGAGRVD VYRTKATGAR IFVEGHDFTG TEDQPAAVET
120 EVVLQPFEDG GWVWFDITTD TAVTLHSGGW YATSPAPGTA NIAVGIPTFN RPADCVNALR
180 ELTADPLVDQ VIGAVIVPDQ GERKVRDHPD FPAAAARLGS RLSIHDQPNL GGSGGYSRVM
240 YEALKNTDCQ QILFMDDDIR LEPDSILRVL AMHRFAKAPM LVGGQMLNLQ EPSHLHIMGE
300 VVDRSIFMWT AAPHAEYDHD FAEYPLNDNN SRSKLLHRRI DVDYNGWWTC MIPRQVAEEL
360 GQPLPLFIKW DDADYGLRAA EHGYPTVTLP GAAIWHMAWS DKDDAIDWQA YFHLRNRLVV
420 AAMHWDGPKA QVIGLVRSHL KATLKHLACL EYSTVAIQNK AIDDFLAGPE HIFSILESAL
480 PQVHRIRKSY PDAVVLPAAS ELPPPLHKNK AMKPPVNPLV IGYRLARGIM HNLTAANPQH
540 HRRPEFNVPT QDARWFLLCT VDGATVTTAD GCGVVYRQRD RAKMFALLWQ SLRRQRQLLK
600 RFEEMRRIYR DALPTLSSKQ KWETALLPAA NQEPEHG
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
38080
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
38081
Mikusova K.,Yagi T.,Stern R.,McNeil M.R.,Besra G.S.,Crick D.C.,Brennan P.J.
Biosynthesis of the galactan component of the mycobacterial cell wall.
J. Biol. Chem.
275
33890-33897
2000
38082
Kremer L.,Dover L.G.,Morehouse C.,Hitchin P.,Everett M.,Morris H.R.,Dell A.,Brennan P.J.,McNeil M.R.,Flaherty C.,Duncan K.,Besra G.S.
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
J. Biol. Chem.
276
26430-26440
2001
38083
Rose N.L.,Completo G.C.,Lin S.J.,McNeil M.,Palcic M.M.,Lowary T.L.
Expression, purification, and characterization of a galactofuranosyltransferase involved in Mycobacterium tuberculosis arabinogalactan biosynthesis.
J. Am. Chem. Soc.
128
6721-6729
2006
38084
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
38085
Rose N.L.,Zheng R.B.,Pearcey J.,Zhou R.,Completo G.C.,Lowary T.L.
Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase.
Carbohydr. Res.
343
2130-2139
2008
38086
Belanova M.,Dianiskova P.,Brennan P.J.,Completo G.C.,Rose N.L.,Lowary T.L.,Mikusova K.
Galactosyl transferases in mycobacterial cell wall synthesis.
J. Bacteriol.
190
1141-1145
2008
38087
May J.F.,Splain R.A.,Brotschi C.,Kiessling L.L.
A tethering mechanism for length control in a processive carbohydrate polymerization.
Proc. Natl. Acad. Sci. U.S.A.
106
11851-11856
2009
38088
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
38089
Wheatley R.W.,Zheng R.B.,Richards M.R.,Lowary T.L.,Ng K.K.
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial arabinogalactan.
J. Biol. Chem.
287
28132-28143
2012