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Sequence of AMO_ARTAN

EC Number:1.14.14.114

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
amorpha-4,11-diene 12-monooxygenase
Q1PS23
Sweet wormwood
495
55711
Reaction
amorpha-4,11-diene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = artemisinate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Other sequences found for EC No. 1.14.14.114

General information:

Sequence
show sequence in fasta format
  0 MKSILKAMAL SLTTSIALAT ILLFVYKFAT RSKSTKKSLP EPWRLPIIGH MHHLIGTTPH
 60 RGVRDLARKY GSLMHLQLGE VPTIVVSSPK WAKEILTTYD ISFANRPETL TGEIVLYHNT
120 DVVLAPYGEY WRQLRKICTL ELLSVKKVKS FQSLREEECW NLVQEIKASG SGRPVNLSEN
180 VFKLIATILS RAAFGKGIKD QKELTEIVKE ILRQTGGFDV ADIFPSKKFL HHLSGKRARL
240 TSLRKKIDNL IDNLVAEHTV NTSSKTNETL LDVLLRLKDS AEFPLTSDNI KAIILDMFGA
300 GTDTSSSTIE WAISELIKCP KAMEKVQAEL RKALNGKEKI HEEDIQELSY LNMVIKETLR
360 LHPPLPLVLP RECRQPVNLA GYNIPNKTKL IVNVFAINRD PEYWKDAEAF IPERFENSSA
420 TVMGAEYEYL PFGAGRRMCP GAALGLANVQ LPLANILYHF NWKLPNGVSY DQIDMTESSG
480 ATMQRKTELL LVPSF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
388971
Ro D.-K.,Paradise E.M.,Ouellet M.,Fisher K.J.,Newman K.L.,Ndungu J.M.,Ho K.A.,Eachus R.A.,Ham T.S.,Kirby J.,Chang M.C.Y.,Withers S.T.,Shiba Y.,Sarpong R.,Keasling J.D.
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
Nature
440
940-943
2006
388975
Yang R.-Y.,Feng L.-L.,Yang X.-Q.,Yin L.-L.,Xu X.-L.,Zeng Q.-P.
Quantitative transcript profiling reveals down-regulation of A sterol pathway relevant gene and overexpression of artemisinin biogenetic genes in transgenic Artemisia annua plants.
Planta Med.
74
1510-1516
2008
388978
Misra A.,Chanotiya C.S.,Gupta M.M.,Dwivedi U.N.,Shasany A.K.
Characterization of cytochrome P450 monooxygenases isolated from trichome enriched fraction of Artemisia annua L. leaf.
Gene
510
193-201
2012
388979
Komori A.,Suzuki M.,Seki H.,Nishizawa T.,Marion Meyer J.J.,Shimizu H.,Yokoyama S.,Muranaka T.
Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene.
FEBS Lett.
587
278-284
2013
388980
Ting H.-M.,Wang B.,Ryden A.-M.,Woittiez L.,van Herpen T.,Verstappen F.W.A.,Ruyter-Spira C.,Beekwilder J.,Bouwmeester H.J.,van der Krol A.
The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage.
New Phytol.
199
352-366
2013
388982
Shen Q.,Zhang L.,Liao Z.,Wang S.,Yan T.,Shi P.,Liu M.,Fu X.,Pan Q.,Wang Y.,Lv Z.,Lu X.,Zhang F.,Jiang W.,Ma Y.,Chen M.,Hao X.,Li L.,Tang Y.,Lv G.,Zhou Y.,Sun X.,Brodelius P.E.,Rose J.K.C.,Tang K.
The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis.
Mol. Plant
11
776-788
2018
388984
Teoh K.H.,Polichuk D.R.,Reed D.W.,Nowak G.,Covello P.S.
Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.
FEBS Lett.
580
1411-1416
2006
388986
Olsson M.E.,Olofsson L.M.,Lindahl A.-L.,Lundgren A.,Brodelius M.,Brodelius P.E.
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.
Phytochemistry
70
1123-1128
2009
388987
Nguyen D.T.,Goepfert J.C.,Ikezawa N.,Macnevin G.,Kathiresan M.,Conrad J.,Spring O.,Ro D.-K.
Biochemical conservation and evolution of germacrene A oxidase in asteraceae.
J. Biol. Chem.
285
16588-16598
2010
388988
Olofsson L.,Engstroem A.,Lundgren A.,Brodelius P.E.
Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.
BMC Plant Biol.
11
45-45
2011
388990
Olofsson L.,Lundgren A.,Brodelius P.E.
Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.
Plant Sci.
183
9-13
2012
388991
Westfall P.J.,Pitera D.J.,Lenihan J.R.,Eng D.,Woolard F.X.,Regentin R.,Horning T.,Tsuruta H.,Melis D.J.,Owens A.,Fickes S.,Diola D.,Benjamin K.R.,Keasling J.D.,Leavell M.D.,McPhee D.J.,Renninger N.S.,Newman J.D.,Paddon C.J.
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin.
Proc. Natl. Acad. Sci. U.S.A.
109
0-0
2012
388992
Paddon C.J.,Westfall P.J.,Pitera D.J.,Benjamin K.,Fisher K.,McPhee D.,Leavell M.D.,Tai A.,Main A.,Eng D.,Polichuk D.R.,Teoh K.H.,Reed D.W.,Treynor T.,Lenihan J.,Fleck M.,Bajad S.,Dang G.,Diola D.,Dorin G.,Ellens K.W.,Fickes S.,Galazzo J.,Gaucher S.P.,Geistlinger T.,Henry R.,Hepp M.,Horning T.,Iqbal T.,Jiang H.,Kizer L.,Lieu B.,Melis D.,Moss N.,Regentin R.,Secrest S.,Tsuruta H.,Vazquez R.,Westblade L.F.,Xu L.,Yu M.,Zhang Y.,Zhao L.,Lievense J.,Covello P.S.,Keasling J.D.,Reiling K.K.,Renninger N.S.,Newman J.D.
High-level semi-synthetic production of the potent antimalarial artemisinin.
Nature
496
528-532
2013
388993
Tu Y.
Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).
Angew. Chem. Int. Ed.
55
10210-10226
2016
388994
Judd R.,Bagley M.C.,Li M.,Zhu Y.,Lei C.,Yuzuak S.,Ekeloef M.,Pu G.,Zhao X.,Muddiman D.C.,Xie D.-Y.
Artemisinin biosynthesis in non-glandular trichome cells of Artemisia annua.
Mol. Plant
12
704-714
2019
388995
Liu Y.,Jing S.-X.,Luo S.-H.,Li S.-H.
Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis.
Nat. Prod. Rep.
36
626-665
2019
388996
Uzun T.,Toptas O.
Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
Chin. Med. J.
15
54-54
2020
388997
Cheong D.H.J.,Tan D.W.S.,Wong F.W.S.,Tran T.
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases.
Pharmacol. Res.
158
104901-104901
2020