Sequence of UCHL3_PLAF7
EC Number:3.4.19.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12
General information:
Sequence
0 MAKNDIWTPL ESNPDSLYLY SCKLGQSKLK FVDIYGFNND LLDMIPQPVQ AVIFLYPVND
60 NIVSENNTND KHNLKENFDN VWFIKQYIPN SCGTIALLHL YGNLRNKFEL DKDSVLDDFF
120 NKVNEMSAEK RGQELKNNKS IENLHHEFCG QVENRDDILD VDTHFIVFVQ IEGKIIELDG
180 RKDHPTVHCF TNGDNFLYDT GKIIQDKFIE KCKDDLRFSA LAVIPNDNFD II
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
372738
Gardner M.J.,Hall N.,Fung E.,White O.,Berriman M.,Hyman R.W.,Carlton J.M.,Pain A.,Nelson K.E.,Bowman S.,Paulsen I.T.,James K.D.,Eisen J.A.,Rutherford K.M.,Salzberg S.L.,Craig A.,Kyes S.,Chan M.-S.,Nene V.,Shallom S.J.,Suh B.,Peterson J.,Angiuoli S.,Pertea M.,Allen J.,Selengut J.,Haft D.,Mather M.W.,Vaidya A.B.,Martin D.M.A.,Fairlamb A.H.,Fraunholz M.J.,Roos D.S.,Ralph S.A.,McFadden G.I.,Cummings L.M.,Subramanian G.M.,Mungall C.,Venter J.C.,Carucci D.J.,Hoffman S.L.,Newbold C.,Davis R.W.,Fraser C.M.,Barrell B.G.
Genome sequence of the human malaria parasite Plasmodium falciparum.
Nature
419
498-511
2002
372739
Frickel E.M.,Quesada V.,Muething L.,Gubbels M.J.,Spooner E.,Ploegh H.,Artavanis-Tsakonas K.
Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.
Cell. Microbiol.
9
1601-1610
2007
372740
Popp M.W.,Artavanis-Tsakonas K.,Ploegh H.L.
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
J. Biol. Chem.
284
3593-3602
2009
372741
Karpiyevich M.,Adjalley S.,Mol M.,Ascher D.B.,Mason B.,van der Heden van Noort G.J.,Laman H.,Ovaa H.,Lee M.C.S.,Artavanis-Tsakonas K.
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.
PLoS Pathog.
15
0-0
2019
372742
Artavanis-Tsakonas K.,Weihofen W.A.,Antos J.M.,Coleman B.I.,Comeaux C.A.,Duraisingh M.T.,Gaudet R.,Ploegh H.L.
Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.
J. Biol. Chem.
285
6857-6866
2010
