Sequence of RIR1_YEAST
EC Number:1.17.4.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ribonucleoside-diphosphate reductase
P21524
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
888
99561
Reaction
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
Other sequences found for EC No. 1.17.4.1
General information:
Sequence
0 MYVYKRDGRK EPVQFDKITA RISRLCYGLD PKHIDAVKVT QRIISGVYEG VTTIELDNLA
60 AETCAYMTTV HPDYATLAAR IAISNLHKQT TKQFSKVVED LYRYVNAATG KPAPMISDDV
120 YNIVMENKDK LNSAIVYDRD FQYSYFGFKT LERSYLLRIN GQVAERPQHL IMRVALGIHG
180 RDIEAALETY NLMSLKYFTH ASPTLFNAGT PKPQMSSCFL VAMKEDSIEG IYDTLKECAL
240 ISKTAGGIGL HIHNIRSTGS YIAGTNGTSN GLIPMIRVFN NTARYVDQGG NKRPGAFALY
300 LEPWHADIFD FIDIRKNHGK EEIRARDLFP ALWIPDLFMK RVEENGTWTL FSPTSAPGLS
360 DCYGDEFEAL YTRYEKEGRG KTIKAQKLWY SILEAQTETG TPFVVYKDAC NRKSNQKNLG
420 VIKSSNLCCE IVEYSAPDET AVCNLASVAL PAFIETSEDG KTSTYNFKKL HEIAKVVTRN
480 LNRVIDRNYY PVEEARKSNM RHRPIALGVQ GLADTFMLLR LPFDSEEARL LNIQIFETIY
540 HASMEASCEL AQKDGPYETF QGSPASQGIL QFDMWDQKPY GMWDWDTLRK DIMKHGVRNS
600 LTMAPMPTAS TSQILGYNEC FEPVTSNMYS RRVLSGEFQV VNPYLLRDLV DLGIWDEGMK
660 QYLITQNGSI QGLPNVPQEL KDLYKTVWEI SQKTIINMAA DRSVYIDQSH SLNLFLRAPT
720 MGKLTSMHFY GWKKGLKTGM YYLRTQAASA AIQFTIDQKI ADQATENVAD ISNLKRPSYM
780 PSSASYAASD FVPAAVTANA TIPSLDSSSE ASREASPAPT GSHSLTKGMA ELNVQESKVE
840 VPEVPAPTKN EEKAAPIVDD EETEFDIYNS KVIACAIDNP EACEMCSG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
345565
Dietrich F.S.,Mulligan J.T.,Hennessy K.M.,Yelton M.A.,Allen E.,Araujo R.,Aviles E.,Berno A.,Brennan T.,Carpenter J.,Chen E.,Cherry J.M.,Chung E.,Duncan M.,Guzman E.,Hartzell G.,Hunicke-Smith S.,Hyman R.W.,Kayser A.,Komp C.,Lashkari D.,Lew H.,Lin D.,Mosedale D.,Nakahara K.,Namath A.,Norgren R.,Oefner P.,Oh C.,Petel F.X.,Roberts D.,Sehl P.,Schramm S.,Shogren T.,Smith V.,Taylor P.,Wei Y.,Botstein D.,Davis R.W.
The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
Nature
387
78-81
1997
345566
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
345567
Elledge S.J.,Davis R.W.
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.
Genes Dev.
4
740-751
1990
345568
Ozier-Kalogeropoulos O.,Adeline M.-T.,Yang W.-L.,Carman G.M.,Lacroute F.
Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae.
Mol. Gen. Genet.
242
431-439
1994
345569
Chabes A.,Domkin V.,Thelander L.
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
J. Biol. Chem.
274
36679-36683
1999
345570
Chabes A.,Domkin V.,Larsson G.,Liu A.,Graeslund A.,Wijmenga S.,Thelander L.
Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.
Proc. Natl. Acad. Sci. U.S.A.
97
2474-2479
2000
345571
Domkin V.,Thelander L.,Chabes A.
Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.
J. Biol. Chem.
277
18574-18578
2002
345572
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
345573
Yao R.,Zhang Z.,An X.,Bucci B.,Perlstein D.L.,Stubbe J.,Huang M.
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways.
Proc. Natl. Acad. Sci. U.S.A.
100
6628-6633
2003
345574
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
345575
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
345576
Starita L.M.,Lo R.S.,Eng J.K.,von Haller P.D.,Fields S.
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Proteomics
12
236-240
2012
345577
Xu H.,Faber C.,Uchiki T.,Fairman J.W.,Racca J.,Dealwis C.
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation.
Proc. Natl. Acad. Sci. U.S.A.
103
4022-4027
2006
345578
Xu H.,Faber C.,Uchiki T.,Racca J.,Dealwis C.
Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
Proc. Natl. Acad. Sci. U.S.A.
103
4028-4033
2006
345579
Xu H.,Fairman J.W.,Wijerathna S.R.,Kreischer N.R.,LaMacchia J.,Helmbrecht E.,Cooperman B.S.,Dealwis C.
The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore.
J. Med. Chem.
51
4653-4659
2008
