Sequence of PTR1_LEITA
EC Number:1.5.1.33
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+
Other sequences found for EC No. 1.5.1.33
General information:
Sequence
0 MTTSPTAPVA LVTGAAKRLG SSIAEALHAE GYTVCLHYHR SAADASTLAA TLNARRPNSA
60 ITVQADLSNV ATASFSETDG SVPVTLFSRC SALVDACYMH WGRCDVLVNN ASSFYPTPLL
120 RKDAGEGGSS VGDKESLEVA AADLFGSNAI APYFLIKAFA QRVADTRAEQ RGTSYSIVNM
180 VDAMTSQPLL GYTMYTMAKE ALEGLTRSAA LELASLQIRV NGVSPGLSVL PDDMPFSVQE
240 DYRRKVPLYQ RNSSAEEVSD VVIFLCSPKA KYITGTCIKV DGGYSLTRA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
339817
Papadopoulou B.,Roy G.,Ouellette M.
A novel antifolate resistance gene on the amplified H circle of Leishmania.
EMBO J.
11
3601-3608
1992
339818
Bello A.R.,Nare B.,Freedman D.,Hardy L.W.,Beverley S.M.
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.
Proc. Natl. Acad. Sci. U.S.A.
91
11442-11446
1994
339819
Zhao H.,Bray T.,Ouellette M.,Zhao M.,Ferre R.A.,Matthews D.,Whiteley J.M.,Varughese K.I.
Structure of pteridine reductase (PTR1) from Leishmania tarentolae.
Acta Crystallogr. D
59
1539-1544
2003
