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Sequence of PTR1_LEIMA

EC Number:1.5.1.33

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
pteridine reductase
Q01782
Leishmania major
288
30457
Reaction
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+
Other sequences found for EC No. 1.5.1.33

General information:

Sequence
show sequence in fasta format
  0 MTAPTVPVAL VTGAAKRLGR SIAEGLHAEG YAVCLHYHRS AAEANALSAT LNARRPNSAI
 60 TVQADLSNVA TAPVSGADGS APVTLFTRCA ELVAACYTHW GRCDVLVNNA SSFYPTPLLR
120 NDEDGHEPCV GDREAMETAT ADLFGSNAIA PYFLIKAFAH RFAGTPAKHR GTNYSIINMV
180 DAMTNQPLLG YTIYTMAKGA LEGLTRSAAL ELAPLQIRVN GVGPGLSVLV DDMPPAVWEG
240 HRSKVPLYQR DSSAAEVSDV VIFLCSSKAK YITGTCVKVD GGYSLTRA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
339810
Callahan H.L.,Beverley S.M.
A member of the aldoketo reductase family confers methotrexate resistance in Leishmania.
J. Biol. Chem.
267
24165-24168
1992
339812
Ivens A.C.,Peacock C.S.,Worthey E.A.,Murphy L.,Aggarwal G.,Berriman M.,Sisk E.,Rajandream M.A.,Adlem E.,Aert R.,Anupama A.,Apostolou Z.,Attipoe P.,Bason N.,Bauser C.,Beck A.,Beverley S.M.,Bianchettin G.,Borzym K.,Bothe G.,Bruschi C.V.,Collins M.,Cadag E.,Ciarloni L.,Clayton C.,Coulson R.M.R.,Cronin A.,Cruz A.K.,Davies R.M.,De Gaudenzi J.,Dobson D.E.,Duesterhoeft A.,Fazelina G.,Fosker N.,Frasch A.C.,Fraser A.,Fuchs M.,Gabel C.,Goble A.,Goffeau A.,Harris D.,Hertz-Fowler C.,Hilbert H.,Horn D.,Huang Y.,Klages S.,Knights A.,Kube M.,Larke N.,Litvin L.,Lord A.,Louie T.,Marra M.,Masuy D.,Matthews K.,Michaeli S.,Mottram J.C.,Mueller-Auer S.,Munden H.,Nelson S.,Norbertczak H.,Oliver K.,O'neil S.,Pentony M.,Pohl T.M.,Price C.,Purnelle B.,Quail M.A.,Rabbinowitsch E.,Reinhardt R.,Rieger M.,Rinta J.,Robben J.,Robertson L.,Ruiz J.C.,Rutter S.,Saunders D.,Schaefer M.,Schein J.,Schwartz D.C.,Seeger K.,Seyler A.,Sharp S.,Shin H.,Sivam D.,Squares R.,Squares S.,Tosato V.,Vogt C.,Volckaert G.,Wambutt R.,Warren T.,Wedler H.,Woodward J.,Zhou S.,Zimmermann W.,Smith D.F.,Blackwell J.M.,Stuart K.D.,Barrell B.G.,Myler P.J.
The genome of the kinetoplastid parasite, Leishmania major.
Science
309
436-442
2005
339813
Bello A.R.,Nare B.,Freedman D.,Hardy L.W.,Beverley S.M.
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.
Proc. Natl. Acad. Sci. U.S.A.
91
11442-11446
1994
339814
Nare B.,Hardy L.W.,Beverley S.M.
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.
J. Biol. Chem.
272
13883-13891
1997
339815
Gourley D.G.,Schuettelkopf A.W.,Leonard G.A.,Luba J.,Hardy L.W.,Beverley S.M.,Hunter W.N.
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.
Nat. Struct. Biol.
8
521-525
2001
339816
Luba J.,Nare B.,Liang P.-H.,Anderson K.S.,Beverley S.M.,Hardy L.W.
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.
Biochemistry
37
4093-4104
1998