Sequence of FCY1_YEAST
EC Number:3.5.4.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cytosine + H2O = uracil + NH3
Other sequences found for EC No. 3.5.4.1
General information:
Sequence
0 MVTGGMASKW DQKGMDIAYE EAALGYKEGG VPIGGCLINN KDGSVLGRGH NMRFQKGSAT
60 LHGEISTLEN CGRLEGKVYK DTTLYTTLSP CDMCTGAIIM YGIPRCVVGE NVNFKSKGEK
120 YLQTRGHEVV VVDDERCKKI MKQFIDERPQ DWFEDIGE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
33217
Erbs P.,Exinger F.,Jund R.
Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans.
Curr. Genet.
31
1-6
1997
33219
Bussey H.,Storms R.K.,Ahmed A.,Albermann K.,Allen E.,Ansorge W.,Araujo R.,Aparicio A.,Barrell B.G.,Badcock K.,Benes V.,Botstein D.,Bowman S.,Brueckner M.,Carpenter J.,Cherry J.M.,Chung E.,Churcher C.M.,Coster F.,Davis K.,Davis R.W.,Dietrich F.S.,Delius H.,DiPaolo T.,Dubois E.,Duesterhoeft A.,Duncan M.,Floeth M.,Fortin N.,Friesen J.D.,Fritz C.,Goffeau A.,Hall J.,Hebling U.,Heumann K.,Hilbert H.,Hillier L.W.,Hunicke-Smith S.,Hyman R.W.,Johnston M.,Kalman S.,Kleine K.,Komp C.,Kurdi O.,Lashkari D.,Lew H.,Lin A.,Lin D.,Louis E.J.,Marathe R.,Messenguy F.,Mewes H.-W.,Mirtipati S.,Moestl D.,Mueller-Auer S.,Namath A.,Nentwich U.,Oefner P.,Pearson D.,Petel F.X.,Pohl T.M.,Purnelle B.,Rajandream M.A.,Rechmann S.,Rieger M.,Riles L.,Roberts D.,Schaefer M.,Scharfe M.,Scherens B.,Schramm S.,Schroeder M.,Sdicu A.-M.,Tettelin H.,Urrestarazu L.A.,Ushinsky S.,Vierendeels F.,Vissers S.,Voss H.,Walsh S.V.,Wambutt R.,Wang Y.,Wedler E.,Wedler H.,Winnett E.,Zhong W.-W.,Zollner A.,Vo D.H.,Hani J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature
387
103-105
1997
33220
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
33221
Kurtz J.-E.,Exinger F.,Erbs P.,Jund R.
New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism.
Curr. Genet.
36
130-136
1999
33222
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
33223
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
33224
Sklenak S.,Yao L.,Cukier R.I.,Yan H.
Catalytic mechanism of yeast cytosine deaminase: an ONIOM computational study.
J. Am. Chem. Soc.
126
14879-14889
2004
33225
Yao L.,Li Y.,Wu Y.,Liu A.,Yan H.
Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase.
Biochemistry
44
5940-5947
2005
33226
Ko T.-P.,Lin J.-J.,Hu C.-Y.,Hsu Y.-H.,Wang A.H.-J.,Liaw S.-H.
Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution.
J. Biol. Chem.
278
19111-19117
2003
33227
Ireton G.C.,Black M.E.,Stoddard B.L.
The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure
11
961-972
2003
33228
Korkegian A.,Black M.E.,Baker D.,Stoddard B.L.
Computational thermostabilization of an enzyme.
Science
308
857-860
2005
