Sequence of PDK4_HUMAN
EC Number:2.7.11.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
Other sequences found for EC No. 2.7.11.2
General information:
Sequence
0 MKAARFVLRS AGSLNGAGLV PREVEHFSRY SPSPLSMKQL LDFGSENACE RTSFAFLRQE
60 LPVRLANILK EIDILPTQLV NTSSVQLVKS WYIQSLMDLV EFHEKSPDDQ KALSDFVDTL
120 IKVRNRHHNV VPTMAQGIIE YKDACTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF
180 SDSQTGNPSH IGSIDPNCDV VAVVQDAFEC SRMLCDQYYL SSPELKLTQV NGKFPDQPIH
240 IVYVPSHLHH MLFELFKNAM RATVEHQENQ PSLTPIEVIV VLGKEDLTIK ISDRGGGVPL
300 RIIDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL YSLSGYGTDA
360 IIYLKALSSE SIEKLPVFNK SAFKHYQMSS EADDWCIPSR EPKNLAKEVA M
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
331997
Rowles J.,Scherer S.W.,Xi T.,Majer M.,Nickle D.C.,Rommens J.M.,Popov K.M.,Harris R.A.,Riebow N.L.,Xia J.,Tsui L.-C.,Bogardus C.,Prochazka M.
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human.
J. Biol. Chem.
271
22376-22382
1996
331998
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
331999
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
332000
Spriet L.L.,Tunstall R.J.,Watt M.J.,Mehan K.A.,Hargreaves M.,Cameron-Smith D.
Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.
J. Appl. Physiol.
96
2082-2087
2004
332001
Abbot E.L.,McCormack J.G.,Reynet C.,Hassall D.G.,Buchan K.W.,Yeaman S.J.
Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.
FEBS J.
272
3004-3014
2005
332002
Degenhardt T.,Saramaki A.,Malinen M.,Rieck M.,Vaisanen S.,Huotari A.,Herzig K.H.,Muller R.,Carlberg C.
Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
J. Mol. Biol.
372
341-355
2007
332003
Grassian A.R.,Metallo C.M.,Coloff J.L.,Stephanopoulos G.,Brugge J.S.
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.
Genes Dev.
25
1716-1733
2011
332004
Blouin J.M.,Penot G.,Collinet M.,Nacfer M.,Forest C.,Laurent-Puig P.,Coumoul X.,Barouki R.,Benelli C.,Bortoli S.
Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
Int. J. Cancer
128
2591-2601
2011
332005
Kulkarni S.S.,Salehzadeh F.,Fritz T.,Zierath J.R.,Krook A.,Osler M.E.
Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.
Metabolism
61
175-185
2012
332006
Wynn R.M.,Kato M.,Chuang J.L.,Tso S.C.,Li J.,Chuang D.T.
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.
J. Biol. Chem.
283
25305-25315
2008
332007
Kukimoto-Niino M.,Tokmakov A.,Terada T.,Ohbayashi N.,Fujimoto T.,Gomi S.,Shiromizu I.,Kawamoto M.,Matsusue T.,Shirouzu M.,Yokoyama S.
Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4.
Acta Crystallogr. D
67
763-773
2011
332008
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
