Sequence of PDK3_HUMAN

[pyruvate dehydrogenase (acetyl-transferring)] kinase

Q15120

406

46939

331974

Gudi R.,Bowker-Kinley M.M.,Kedishvili N.Y.,Zhao Y.,Popov K.M.

Diversity of the pyruvate dehydrogenase kinase gene family in humans.

J. Biol. Chem.

270

28989-28994

1995

331975

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

331977

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

331978

Baker J.C.,Yan X.,Peng T.,Kasten S.,Roche T.E.

Marked differences between two isoforms of human pyruvate dehydrogenase kinase.

J. Biol. Chem.

275

15773-15781

2000

331979

Korotchkina L.G.,Patel M.S.

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.

J. Biol. Chem.

276

37223-37229

2001

331980

Tuganova A.,Boulatnikov I.,Popov K.M.

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.

Biochem. J.

366

129-136

2002

331981

Korotchkina L.G.,Sidhu S.,Patel M.S.

Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase.

J. Biol. Chem.

281

9688-9696

2006

331982

Degenhardt T.,Saramaki A.,Malinen M.,Rieck M.,Vaisanen S.,Huotari A.,Herzig K.H.,Muller R.,Carlberg C.

Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

J. Mol. Biol.

372

341-355

2007

331983

Lu C.W.,Lin S.C.,Chen K.F.,Lai Y.Y.,Tsai S.J.

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.

J. Biol. Chem.

283

28106-28114

2008

331984

Blouin J.M.,Penot G.,Collinet M.,Nacfer M.,Forest C.,Laurent-Puig P.,Coumoul X.,Barouki R.,Benelli C.,Bortoli S.

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

Int. J. Cancer

128

2591-2601

2011

331985

Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci. Signal.

4

0-0

2011

331986

Kluza J.,Corazao-Rozas P.,Touil Y.,Jendoubi M.,Maire C.,Guerreschi P.,Jonneaux A.,Ballot C.,Balayssac S.,Valable S.,Corroyer-Dulmont A.,Bernaudin M.,Malet-Martino M.,de Lassalle E.M.,Maboudou P.,Formstecher P.,Polakowska R.,Mortier L.,Marchetti P.

Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

Cancer Res.

72

5035-5047

2012

331987

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

331988

Kato M.,Chuang J.L.,Tso S.C.,Wynn R.M.,Chuang D.T.

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.

EMBO J.

24

1763-1774

2005

331989

Devedjiev Y.,Steussy C.N.,Vassylyev D.G.

Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.

J. Mol. Biol.

370

407-416

2007

331990

Kato M.,Li J.,Chuang J.L.,Chuang D.T.

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Structure

15

992-1004

2007

331991

Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.

Patterns of somatic mutation in human cancer genomes.

Nature

446

153-158

2007

331992

Kennerson M.L.,Yiu E.M.,Chuang D.T.,Kidambi A.,Tso S.C.,Ly C.,Chaudhry R.,Drew A.P.,Rance G.,Delatycki M.B.,Zuchner S.,Ryan M.M.,Nicholson G.A.

A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.

Hum. Mol. Genet.

22

1404-1416

2013