Sequence of PAPA5_MYCTU
EC Number:2.3.1.282
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase
P9WIN5
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
422
45429
Reaction
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
Other sequences found for EC No. 2.3.1.282
General information:
Sequence
0 MFPGSVIRKL SHSEEVFAQY EVFTSMTIQL RGVIDVDALS DAFDALLETH PVLASHLEQS
60 SDGGWNLVAD DLLHSGICVI DGTAATNGSP SGNAELRLDQ SVSLLHLQLI LREGGAELTL
120 YLHHCMADGH HGAVLVDELF SRYTDAVTTG DPGPITPQPT PLSMEAVLAQ RGIRKQGLSG
180 AERFMSVMYA YEIPATETPA VLAHPGLPQA VPVTRLWLSK QQTSDLMAFG REHRLSLNAV
240 VAAAILLTEW QLRNTPHVPI PYVYPVDLRF VLAPPVAPTE ATNLLGAASY LAEIGPNTDI
300 VDLASDIVAT LRADLANGVI QQSGLHFGTA FEGTPPGLPP LVFCTDATSF PTMRTPPGLE
360 IEDIKGQFYC SISVPLDLYS CAVYAGQLII EHHGHIAEPG KSLEAIRSLL CTVPSEYGWI
420 ME
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
330909
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
330910
Onwueme K.C.,Ferreras J.A.,Buglino J.,Lima C.D.,Quadri L.E.N.
Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5.
Proc. Natl. Acad. Sci. U.S.A.
101
4608-4613
2004
330912
Trivedi O.A.,Arora P.,Vats A.,Ansari M.Z.,Tickoo R.,Sridharan V.,Mohanty D.,Gokhale R.S.
Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid.
Mol. Cell
17
631-643
2005
330913
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
330914
Gupta M.,Sajid A.,Arora G.,Tandon V.,Singh Y.
Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis.
J. Biol. Chem.
284
34723-34734
2009
330915
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
330916
Chavadi S.S.,Onwueme K.C.,Edupuganti U.R.,Jerome J.,Chatterjee D.,Soll C.E.,Quadri L.E.
The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids.
Microbiology
158
1379-1387
2012
330917
Touchette M.H.,Bommineni G.R.,Delle Bovi R.J.,Gadbery J.E.,Nicora C.D.,Shukla A.K.,Kyle J.E.,Metz T.O.,Martin D.W.,Sampson N.S.,Miller W.T.,Tonge P.J.,Seeliger J.C.
Diacyltransferase activity and chain length specificity of Mycobacterium tuberculosis PapA5 in the synthesis of alkyl beta-diol lipids.
Biochemistry
54
5457-5468
2015
330918
Buglino J.,Onwueme K.C.,Ferreras J.A.,Quadri L.E.N.,Lima C.D.
Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis.
J. Biol. Chem.
279
30634-30642
2004
