Sequence of PA2BC_VIPAA
EC Number:3.1.1.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Other sequences found for EC No. 3.1.1.4
General information:
Sequence
0 MRTLWIVAVC LIGVEGSLLE FGMMILGETG KNPLTSYSFY GCYCGVGGKG TPKDATDRCC
60 FVHDCCYGNL PDCSPKTDRY KYHRENGAIV CGKGTSCENR ICECDRAAAI CFRKNLKTYN
120 YIYRNYPDIL CKEESEKC
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
330277
Pungercar J.,Kordis D.,Jerala R.,Trstenjak-Prebanda M.,Dolinar M.,Curin-Serbec V.,Komel R.,Gubensek F.
Amino acid sequence of ammodytoxin C as deduced from cDNA.
Nucleic Acids Res.
17
4367-4367
1989
330278
Kordis D.,Gubensek F.
Ammodytoxin C gene helps to elucidate the irregular structure of Crotalinae group II phospholipase A2 genes.
Eur. J. Biochem.
240
83-90
1996
330279
Krizaj I.,Turk D.,Ritonja A.,Gubensek F.
Primary structure of ammodytoxin C further reveals the toxic site of ammodytoxin.
Biochim. Biophys. Acta
999
198-202
1989
330280
Krizaj I.
Ammodytoxin: a window into understanding presynaptic toxicity of secreted phospholipases A(2) and more.
Toxicon
58
219-229
2011
330281
Vucemilo N.,Copic A.,Gubensek F.,Krizaj I.
Identification of a new high-affinity binding protein for neurotoxic phospholipases A2.
Biochem. Biophys. Res. Commun.
251
209-212
1998
330282
Pungercar J.,Krizaj I.,Liang N.-S.,Gubensek F.
An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins.
Biochem. J.
341
139-145
1999
330283
Sribar J.,Copic A.,Paris A.,Sherman N.E.,Gubensek F.,Fox J.W.,Krizaj I.
A high affinity acceptor for phospholipase A2 with neurotoxic activity is a calmodulin.
J. Biol. Chem.
276
12493-12496
2001
330284
Fathi B.,Rowan E.G.,Harvey A.L.
The facilitatory actions of snake venom phospholipase A(2) neurotoxins at the neuromuscular junction are not mediated through voltage-gated K(+) channels.
Toxicon
39
1871-1882
2001
330285
Sribar J.,Sherman N.E.,Prijatelj P.,Faure G.,Gubensek F.,Fox J.W.,Aitken A.,Pungercar J.,Krizaj I.
The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms.
Biochem. Biophys. Res. Commun.
302
691-696
2003
330286
Sribar J.,Copic A.,Poljsak-Prijatelj M.,Kuret J.,Logonder U.,Gubensek F.,Krizaj I.
R25 is an intracellular membrane receptor for a snake venom secretory phospholipase A(2).
FEBS Lett.
553
309-314
2003
330287
Petan T.,Krizaj I.,Gelb M.H.,Pungercar J.
Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes.
Biochemistry
44
12535-12545
2005
330288
Prijatelj P.,Charnay M.,Ivanovski G.,Jenko Z.,Pungercar J.,Krizaj I.,Faure G.
The C-terminal and beta-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect.
Biochimie
88
69-76
2006
330289
Saul F.A.,Prijatelj-Znidarsic P.,Vulliez-le Normand B.,Villette B.,Raynal B.,Pungercar J.,Krizaj I.,Faure G.
Comparative structural studies of two natural isoforms of ammodytoxin, phospholipases A2 from Vipera ammodytes ammodytes which differ in neurotoxicity and anticoagulant activity.
J. Struct. Biol.
169
360-369
2010
