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Sequence of MACD1_HUMAN

EC Number:3.1.1.106

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
O-acetyl-ADP-ribose deacetylase
Q9BQ69
Homo sapiens
325
35505
Reaction
2''-O-acetyl-ADP-D-ribose + H2O = ADP-D-ribose + acetate
Other sequences found for EC No. 3.1.1.106

General information:

Sequence
show sequence in fasta format
  0 MSLQSRLSGR LAQLRAAGQL LVPPRPRPGH LAGATRTRSS TCGPPAFLGV FGRRARTSAG
 60 VGAWGAAAVG RTAGVRTWAP LAMAAKVDLS TSTDWKEAKS FLKGLSDKQR EEHYFCKDFV
120 RLKKIPTWKE MAKGVAVKVE EPRYKKDKQL NEKISLLRSD ITKLEVDAIV NAANSSLLGG
180 GGVDGCIHRA AGPLLTDECR TLQSCKTGKA KITGGYRLPA KYVIHTVGPI AYGEPSASQA
240 AELRSCYLSS LDLLLEHRLR SVAFPCISTG VFGYPCEAAA EIVLATLREW LEQHKDKVDR
300 LIICVFLEKD EDIYRSRLPH YFPVA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
315593
Han W.-D.,Yu L.,Lou F.D.,Wang Q.S.,Zhao Y.,Shi Z.J.,Jin H.J.
The application of RACE technique to clone the full-length cDNA of a novel leukemia associated gene LRP16.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
9
18-21
2001
315594
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
315595
Han W.-D.,Mu Y.-M.,Lu X.-C.,Xu Z.-M.,Li X.-J.,Yu L.,Song H.-J.,Li M.,Lu J.-M.,Zhao Y.-L.,Pan C.-Y.
Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report.
Endocr. Relat. Cancer
10
217-224
2003
315596
Meng Y.G.,Han W.-D.,Zhao Y.-L.,Huang K.,Si Y.-L.,Wu Z.-Q.,Mu Y.-M.
Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin.
Cell Res.
17
869-880
2007
315597
Han W.-D.,Zhao Y.-L.,Meng Y.G.,Zang L.,Wu Z.-Q.,Li Q.,Si Y.-L.,Huang K.,Ba J.-M.,Morinaga H.,Nomura M.,Mu Y.-M.
Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity.
Endocr. Relat. Cancer
14
741-753
2007
315598
Imagama S.,Abe A.,Suzuki M.,Hayakawa F.,Katsumi A.,Emi N.,Kiyoi H.,Naoe T.
LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).
Eur. J. Haematol.
79
25-31
2007
315599
Yang J.,Zhao Y.-L.,Wu Z.-Q.,Si Y.-L.,Meng Y.G.,Fu X.B.,Mu Y.-M.,Han W.-D.
The single-macro domain protein LRP16 is an essential cofactor of androgen receptor.
Endocr. Relat. Cancer
16
139-153
2009
315600
Tian L.,Wu Z.,Zhao Y.,Meng Y.,Si Y.,Fu X.,Mu Y.,Han W.
Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells.
J. Endocrinol.
202
167-177
2009
315601
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
315602
Rosenthal F.,Feijs K.L.,Frugier E.,Bonalli M.,Forst A.H.,Imhof R.,Winkler H.C.,Fischer D.,Caflisch A.,Hassa P.O.,Luescher B.,Hottiger M.O.
Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.
Nat. Struct. Mol. Biol.
20
502-507
2013
315603
Jankevicius G.,Hassler M.,Golia B.,Rybin V.,Zacharias M.,Timinszky G.,Ladurner A.G.
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.
Nat. Struct. Mol. Biol.
20
508-514
2013
315604
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
315605
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
315606
Stevens L.A.,Kato J.,Kasamatsu A.,Oda H.,Lee D.Y.,Moss J.
The ARH and Macrodomain Families of alpha-ADP-ribose-acceptor Hydrolases Catalyze alpha-NAD+ Hydrolysis.
ACS Chem. Biol.
14
2576-2584
2019
315607
Chen D.,Vollmar M.,Rossi M.N.,Phillips C.,Kraehenbuehl R.,Slade D.,Mehrotra P.V.,von Delft F.,Crosthwaite S.K.,Gileadi O.,Denu J.M.,Ahel I.
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
J. Biol. Chem.
286
13261-13271
2011