Sequence of LOX15_HUMAN
EC Number:1.13.11.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Other sequences found for EC No. 1.13.11.31
General information:
Sequence
0 MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL
60 LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP
120 QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK
180 GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV
240 LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL
300 VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH
360 LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST
420 GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS
480 LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH
540 ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ
600 PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV
660 AI
Download this sequence
Download all sequences for 1.13.11.31
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
313836
Sigal E.,Craik C.S.,Highland E.,Grunberger D.,Costello L.L.,Dixon R.A.F.,Nadel J.A.
Molecular cloning and primary structure of human 15-lipoxygenase.
Biochem. Biophys. Res. Commun.
157
457-464
1988
313837
Kritzik M.R.,Ziober A.F.,Dicharry S.,Conrad D.J.,Sigal E.
Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.
Biochim. Biophys. Acta
1352
267-281
1997
313838
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
313840
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
313841
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
313842
Kelavkar U.,Wang S.,Montero A.,Murtagh J.,Shah K.,Badr K.
Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes.
Mol. Biol. Rep.
25
173-182
1998
313843
Sigal E.,Grunberger D.,Craik C.S.,Caughey G.H.,Nadel J.A.
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
J. Biol. Chem.
263
5328-5332
1988
313844
Izumi T.,Raadmark O.,Joernvall H.,Samuelsson B.
Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes.
Eur. J. Biochem.
202
1231-1238
1991
313845
Sloane D.L.,Leung R.,Craik C.S.,Sigal E.
A primary determinant for lipoxygenase positional specificity.
Nature
354
149-152
1991
313846
Kuehn H.,Barnett J.,Grunberger D.,Baecker P.,Chow J.,Nguyen B.,Bursztyn-Pettegrew H.,Chan H.,Sigal E.
Overexpression, purification and characterization of human recombinant 15-lipoxygenase.
Biochim. Biophys. Acta
1169
80-89
1993
313847
Brinckmann R.,Schnurr K.,Heydeck D.,Rosenbach T.,Kolde G.,Kuehn H.
Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme.
Blood
91
64-74
1998
313848
Hsi L.C.,Kamitani H.,Cornicelli J.A.,Eling T.E.
Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.
Prostaglandins Leukot. Essent. Fatty Acids
64
217-225
2001
313849
Andersson E.,Schain F.,Svedling M.,Claesson H.E.,Forsell P.K.
Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.
Biochim. Biophys. Acta
1761
1498-1505
2006
313850
Yoo H.,Jeon B.,Jeon M.S.,Lee H.,Kim T.Y.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
FEBS Lett.
582
3249-3253
2008
313851
Weibel G.L.,Joshi M.R.,Wei C.,Bates S.R.,Blair I.A.,Rothblat G.H.
15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism.
J. Lipid Res.
50
2371-2376
2009
313852
Zhao J.,O'Donnell V.B.,Balzar S.,St Croix C.M.,Trudeau J.B.,Wenzel S.E.
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Proc. Natl. Acad. Sci. U.S.A.
108
14246-14251
2011
313853
Jin J.,Zheng Y.,Boeglin W.E.,Brash A.R.
Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration.
J. Lipid Res.
54
754-761
2013
313854
Horn T.,Reddy Kakularam K.,Anton M.,Richter C.,Reddanna P.,Kuhn H.
Functional characterization of genetic enzyme variations in human lipoxygenases.
Redox Biol.
1
566-577
2013
313855
Teder T.,Boeglin W.E.,Brash A.R.
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.
J. Lipid Res.
55
2587-2596
2014
313856
Perry S.C.,Kalyanaraman C.,Tourdot B.E.,Conrad W.S.,Akinkugbe O.,Freedman J.C.,Holinstat M.,Jacobson M.P.,Holman T.R.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
J. Lipid Res.
61
1087-1103
2020
313857
Assimes T.L.,Knowles J.W.,Priest J.R.,Basu A.,Borchert A.,Volcik K.A.,Grove M.L.,Tabor H.K.,Southwick A.,Tabibiazar R.,Sidney S.,Boerwinkle E.,Go A.S.,Iribarren C.,Hlatky M.A.,Fortmann S.P.,Myers R.M.,Kuhn H.,Risch N.,Quertermous T.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Atherosclerosis
198
136-144
2008