Sequence of LOX12_HUMAN
EC Number:1.13.11.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Other sequences found for EC No. 1.13.11.31
General information:
Sequence
0 MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL
60 QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA
120 LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA
180 GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML
240 LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL
300 VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH
360 LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST
420 GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH
480 LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH
540 AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR
600 QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS
660 VTI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
313783
Yoshimoto T.,Yamamoto Y.,Arakawa T.,Suzuki H.,Yamamoto S.,Yokoyama C.,Tanabe T.,Toh H.
Molecular cloning and expression of human arachidonate 12-lipoxygenase.
Biochem. Biophys. Res. Commun.
172
1230-1235
1990
313784
Funk C.D.,Furci L.,Fitzgerald G.A.
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.
Proc. Natl. Acad. Sci. U.S.A.
87
5638-5642
1990
313785
Izumi T.,Hoshiko S.,Raadmark O.,Samuelsson B.
Cloning of the cDNA for human 12-lipoxygenase.
Proc. Natl. Acad. Sci. U.S.A.
87
7477-7481
1990
313787
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
313788
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
313789
Yoshimoto T.,Arakawa T.,Hada T.,Yamamoto S.,Takahashi E.
Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.
J. Biol. Chem.
267
24805-24809
1992
313790
Funk C.D.,Funk L.B.,Fitzgerald G.A.,Samuelsson B.
Characterization of human 12-lipoxygenase genes.
Proc. Natl. Acad. Sci. U.S.A.
89
3962-3966
1992
313791
Hussain H.,Shornick L.P.,Shannon V.R.,Wilson J.D.,Funk C.D.,Pentland A.P.,Holtzman M.J.
Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.
Am. J. Physiol.
266
0-0
1994
313793
Hada T.,Ueda N.,Takahashi Y.,Yamamoto S.
Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.
Biochim. Biophys. Acta
1083
89-93
1991
313794
Romano M.,Chen X.S.,Takahashi Y.,Yamamoto S.,Funk C.D.,Serhan C.N.
Lipoxin synthase activity of human platelet 12-lipoxygenase.
Biochem. J.
296
127-133
1993
313795
Chen X.S.,Brash A.R.,Funk C.D.
Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.
Eur. J. Biochem.
214
845-852
1993
313796
Chen X.S.,Funk C.D.
Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies.
FASEB J.
7
694-701
1993
313797
Hagmann W.,Gao X.,Timar J.,Chen Y.Q.,Strohmaier A.R.,Fahrenkopf C.,Kagawa D.,Lee M.,Zacharek A.,Honn K.V.
12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
Exp. Cell Res.
228
197-205
1996
313798
Nie D.,Hillman G.G.,Geddes T.,Tang K.,Pierson C.,Grignon D.J.,Honn K.V.
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Cancer Res.
58
4047-4051
1998
313799
Nie D.,Krishnamoorthy S.,Jin R.,Tang K.,Chen Y.,Qiao Y.,Zacharek A.,Guo Y.,Milanini J.,Pages G.,Honn K.V.
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
J. Biol. Chem.
281
18601-18609
2006
313800
Prusakiewicz J.J.,Turman M.V.,Vila A.,Ball H.L.,Al-Mestarihi A.H.,Di Marzo V.,Marnett L.J.
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Arch. Biochem. Biophys.
464
260-268
2007
313801
Turman M.V.,Kingsley P.J.,Rouzer C.A.,Cravatt B.F.,Marnett L.J.
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
Biochemistry
47
3917-3925
2008
313802
Yoo H.,Jeon B.,Jeon M.S.,Lee H.,Kim T.Y.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
FEBS Lett.
582
3249-3253
2008
313803
Klampfl T.,Bogner E.,Bednar W.,Mager L.,Massudom D.,Kalny I.,Heinzle C.,Berger W.,Staettner S.,Karner J.,Klimpfinger M.,Fuerstenberger G.,Krieg P.,Marian B.
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Exp. Cell Res.
318
768-778
2012
313804
Weisinger G.,Grafi-Cohen M.,Hirsh M.,Knoll E.,Sharon O.,Many A.,Limor R.,Stern N.
12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.
Exp. Cell Res.
319
1586-1593
2013
313805
Ikei K.N.,Yeung J.,Apopa P.L.,Ceja J.,Vesci J.,Holman T.R.,Holinstat M.
Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
J. Lipid Res.
53
2546-2559
2012
313806
Dalli J.,Zhu M.,Vlasenko N.A.,Deng B.,Haeggstroem J.Z.,Petasis N.A.,Serhan C.N.
The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.
FASEB J.
27
2573-2583
2013
313807
Horn T.,Reddy Kakularam K.,Anton M.,Richter C.,Reddanna P.,Kuhn H.
Functional characterization of genetic enzyme variations in human lipoxygenases.
Redox Biol.
1
566-577
2013
313808
Deng B.,Wang C.W.,Arnardottir H.H.,Li Y.,Cheng C.Y.,Dalli J.,Serhan C.N.
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
PLoS ONE
9
0-0
2014
313809
Perry S.C.,Kalyanaraman C.,Tourdot B.E.,Conrad W.S.,Akinkugbe O.,Freedman J.C.,Holinstat M.,Jacobson M.P.,Holman T.R.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
J. Lipid Res.
61
1087-1103
2020
313811
Goodman J.E.,Bowman E.D.,Chanock S.J.,Alberg A.J.,Harris C.C.
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Carcinogenesis
25
2467-2472
2004
313812
Tan W.,Wu J.,Zhang X.,Guo Y.,Liu J.,Sun T.,Zhang B.,Zhao D.,Yang M.,Yu D.,Lin D.
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
Carcinogenesis
28
1197-1201
2007
313813
Guo Y.,Zhang X.,Tan W.,Miao X.,Sun T.,Zhao D.,Lin D.
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Pharmacogenet. Genomics
17
197-205
2007
