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Sequence of EZH2_HUMAN

EC Number:2.1.1.356

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
[histone H3]-lysine27 N-trimethyltransferase
Q15910
Homo sapiens
746
85363
Reaction
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Other sequences found for EC No. 2.1.1.356

General information:

Sequence
show sequence in fasta format
  0 MGQTGKKSEK GPVCWRKRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL ERTEILNQEW
 60 KQRRIQPVHI LTSVSSLRGT RECSVTSDLD FPTQVIPLKT LNAVASVPIM YSWSPLQQNF
120 MVEDETVLHN IPYMGDEVLD QDGTFIEELI KNYDGKVHGD RECGFINDEI FVELVNALGQ
180 YNDDDDDDDG DDPEEREEKQ KDLEDHRDDK ESRPPRKFPS DKIFEAISSM FPDKGTAEEL
240 KEKYKELTEQ QLPGALPPEC TPNIDGPNAK SVQREQSLHS FHTLFCRRCF KYDCFLHPFH
300 ATPNTYKRKN TETALDNKPC GPQCYQHLEG AKEFAAALTA ERIKTPPKRP GGRRRGRLPN
360 NSSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KDETSSSSEA NSRCQTPIKM
420 KPNIEPPENV EWSGAEASMF RVLIGTYYDN FCAIARLIGT KTCRQVYEFR VKESSIIAPA
480 PAEDVDTPPR KKKRKHRLWA AHCRKIQLKK DGSSNHVYNY QPCDHPRQPC DSSCPCVIAQ
540 NFCEKFCQCS SECQNRFPGC RCKAQCNTKQ CPCYLAVREC DPDLCLTCGA ADHWDSKNVS
600 CKNCSIQRGS KKHLLLAPSD VAGWGIFIKD PVQKNEFISE YCGEIISQDE ADRRGKVYDK
660 YMCSFLFNLN NDFVVDATRK GNKIRFANHS VNPNCYAKVM MVNGDHRIGI FAKRAIQTGE
720 ELFFDYRYSQ ADALKYVGIE REMEIP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
31945
Chen H.,Rossier C.,Antonarakis S.E.
Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.
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Cardoso C.,Timsit S.,Villard L.,Khrestchatisky M.,Fontes M.,Colleaux L.
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2004
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Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.
Mol. Cell
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2004
31963
Cao R.,Zhang Y.
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
Mol. Cell
15
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2004
31964
Tang X.,Milyavsky M.,Shats I.,Erez N.,Goldfinger N.,Rotter V.
Activated p53 suppresses the histone methyltransferase EZH2 gene.
Oncogene
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2004
31965
Epping M.T.,Wang L.,Edel M.J.,Carlee L.,Hernandez M.,Bernards R.
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
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31967
Cha T.-L.,Zhou B.P.,Xia W.,Wu Y.,Yang C.-C.,Chen C.-T.,Ping B.,Otte A.P.,Hung M.-C.
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Science
310
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31968
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
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31969
Bracken A.P.,Dietrich N.,Pasini D.,Hansen K.H.,Helin K.
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
Genes Dev.
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2006
31970
Martin C.,Cao R.,Zhang Y.
Substrate preferences of the EZH2 histone methyltransferase complex.
J. Biol. Chem.
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31971
Etchegaray J.P.,Yang X.,DeBruyne J.P.,Peters A.H.,Weaver D.R.,Jenuwein T.,Reppert S.M.
The polycomb group protein EZH2 is required for mammalian circadian clock function.
J. Biol. Chem.
281
21209-21215
2006
31972
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
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24
1285-1292
2006
31973
Vire E.,Brenner C.,Deplus R.,Blanchon L.,Fraga M.,Didelot C.,Morey L.,Van Eynde A.,Bernard D.,Vanderwinden J.-M.,Bollen M.,Esteller M.,Di Croce L.,de Launoit Y.,Fuks F.
The Polycomb group protein EZH2 directly controls DNA methylation.
Nature
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2006
31975
Kim D.H.,Villeneuve L.M.,Morris K.V.,Rossi J.J.
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.
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2006
31976
Kotake Y.,Cao R.,Viatour P.,Sage J.,Zhang Y.,Xiong Y.
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2007
31977
Bracken A.P.,Kleine-Kohlbrecher D.,Dietrich N.,Pasini D.,Gargiulo G.,Beekman C.,Theilgaard-Moench K.,Minucci S.,Porse B.T.,Marine J.-C.,Hansen K.H.,Helin K.
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21
525-530
2007
31978
Schlesinger Y.,Straussman R.,Keshet I.,Farkash S.,Hecht M.,Zimmerman J.,Eden E.,Yakhini Z.,Ben-Shushan E.,Reubinoff B.E.,Bergman Y.,Simon I.,Cedar H.
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232-236
2007
31979
Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III
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2008
31980
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
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2008
31981
Margueron R.,Li G.,Sarma K.,Blais A.,Zavadil J.,Woodcock C.L.,Dynlacht B.D.,Reinberg D.
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Mol. Cell
32
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2008
31982
Cao R.,Wang H.,He J.,Erdjument-Bromage H.,Tempst P.,Zhang Y.
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Sarma K.,Margueron R.,Ivanov A.,Pirrotta V.,Reinberg D.
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
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2008
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Riising E.M.,Boggio R.,Chiocca S.,Helin K.,Pasini D.
The polycomb repressive complex 2 is a potential target of SUMO modifications.
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Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Proc. Natl. Acad. Sci. U.S.A.
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