Sequence of LACC1_HUMAN
EC Number:2.4.2.28
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
Other sequences found for EC No. 2.4.2.28
General information:
Sequence
0 MAEAVLIDLF GLKLNSQKNC HQTLLKTLNA VQYHHAAKAK FLCIMCCSNI SYERDGEQDN
60 CEIETSNGLS ALLEEFEIVS CPSMAATLYT IKQKIDEKNL SSIKVIVPRH RKTLMKAFID
120 QLFTDVYNFE FEDLQVTFRG GLFKQSIEIN VITAQELRGI QNEIETFLRS LPALRGKLTI
180 ITSSLIPDIF IHGFTTRTGG ISYIPTLSSF NLFSSSKRRD PKVVVQENLR RLANAAGFNV
240 EKFYRIKTHH SNDIWIMGRK EPDSYDGITT NQRGVTIAAL GADCIPIVFA DPVKKACGVA
300 HAGWKGTLLG VAMATVNAMI AEYGCSLEDI VVVLGPSVGP CCFTLPRESA EAFHNLHPAC
360 VQLFDSPNPC IDIRKATRIL LEQGGILPQN IQDQNQDLNL CTSCHPDKFF SHVRDGLNFG
420 TQIGFISIKE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
311827
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
311828
Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.
The DNA sequence and analysis of human chromosome 13.
Nature
428
522-528
2004
311830
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
311831
Wakil S.M.,Monies D.M.,Abouelhoda M.,Al-Tassan N.,Al-Dusery H.,Naim E.A.,Al-Younes B.,Shinwari J.,Al-Mohanna F.A.,Meyer B.F.,Al-Mayouf S.
Association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis.
Arthritis Rheum.
67
288-295
2015
311832
Cader M.Z.,Boroviak K.,Zhang Q.,Assadi G.,Kempster S.L.,Sewell G.W.,Saveljeva S.,Ashcroft J.W.,Clare S.,Mukhopadhyay S.,Brown K.P.,Tschurtschenthaler M.,Raine T.,Doe B.,Chilvers E.R.,Griffin J.L.,Kaneider N.C.,Floto R.A.,D'Amato M.,Bradley A.,Wakelam M.J.,Dougan G.,Kaser A.
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Nat. Immunol.
17
1046-1056
2016
311833
Assadi G.,Vesterlund L.,Bonfiglio F.,Mazzurana L.,Cordeddu L.,Schepis D.,Mjoesberg J.,Ruhrmann S.,Fabbri A.,Vukojevic V.,Percipalle P.,Salomons F.A.,Laurencikiene J.,Toerkvist L.,Halfvarson J.,D'Amato M.
Functional Analyses of the Crohn's Disease Risk Gene LACC1.
PLoS ONE
11
0-0
2016
311834
Kallinich T.,Thorwarth A.,von Stuckrad S.L.,Roesen-Wolff A.,Luksch H.,Hundsdoerfer P.,Minden K.,Krawitz P.
Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.
Pediatr. Rheumatol. Online J.
14
63-63
2016
311835
Lahiri A.,Hedl M.,Yan J.,Abraham C.
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.
Nat. Commun.
8
15614-15614
2017
311836
Karacan I.,Ugurlu S.,Sahin S.,Everest E.,Kasapcopur O.,Tolun A.,Oezdogan H.,Turanli E.T.
LACC1 gene defects in familial form of juvenile arthritis.
J. Rheumatol.
45
726-728
2018
311837
Singh A.,Suri D.,Vignesh P.,Anjani G.,Jacob P.,Girisha K.M.
LACC1 gene mutation in three sisters with polyarthritis without systemic features.
Ann. Rheum. Dis.
79
425-426
2020
311838
Rabionet R.,Remesal A.,Mensa-Vilaro A.,Murias S.,Alcobendas R.,Gonzalez-Roca E.,Ruiz-Ortiz E.,Anton J.,Iglesias E.,Modesto C.,Comas D.,Puig A.,Drechsel O.,Ossowski S.,Yaguee J.,Merino R.,Estivill X.,Arostegui J.I.
Biallelic loss-of-function LACC1/FAMIN mutations presenting as rheumatoid factor-negative polyarticular juvenile idiopathic arthritis.
Sci. Rep.
9
4579-4579
2019
311839
Cader M.Z.,de Almeida Rodrigues R.P.,West J.A.,Sewell G.W.,Md-Ibrahim M.N.,Reikine S.,Sirago G.,Unger L.W.,Inglesias-Romero A.B.,Ramshorn K.,Haag L.M.,Saveljeva S.,Ebel J.F.,Rosenstiel P.,Kaneider N.C.,Lee J.C.,Lawley T.D.,Bradley A.,Dougan G.,Modis Y.,Griffin J.L.,Kaser A.
FAMIN is a multifunctional purine enzyme enabling the purine nucleotide cycle.
Cell
180
278-295
2020
311840
Huang C.,Hedl M.,Ranjan K.,Abraham C.
LACC1 required for NOD2-induced, ER stress-mediated innate immune outcomes in human macrophages and LACC1 risk variants modulate these outcomes.
Cell Rep.
29
4525-4539
2019
