Sequence of DDR1_HUMAN
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR
60 HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL
120 RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV
180 ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD
240 FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG
300 VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS
360 EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI
420 GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE
480 PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT
540 QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP
600 PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD
660 ATKNARNDFL KEVKIMSRLK DPNIIRLLGV CVQDDPLCMI TDYMENGDLN QFLSAHQLED
720 KAAEGAPGDG QAAQGPTISY PMLLHVAAQI ASGMRYLATL NFVHRDLATR NCLVGENFTI
780 KIADFGMSRN LYAGDYYRVQ GRAVLPIRWM AWECILMGKF TTASDVWAFG VTLWEVLMLC
840 RAQPFGQLTD EQVIENAGEF FRDQGRQVYL SRPPACPQGL YELMLRCWSR ESEQRPPFSQ
900 LHRFLAEDAL NTV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
283427
di Marco E.,Cutuli N.,Guerra L.,Cancedda R.,de Luca M.
Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.
J. Biol. Chem.
268
24290-24295
1993
283428
Johnson J.D.,Edman J.C.,Rutter W.J.
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.
Proc. Natl. Acad. Sci. U.S.A.
90
5677-5681
1993
283429
Laval S.,Butler R.,Shelling A.N.,Hanby A.M.,Poulsom R.,Ganesan T.S.
Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.
Cell Growth Differ.
5
1173-1183
1994
283430
Perez J.L.,Shen X.,Finkernagel S.,Sciorra L.,Jenkins N.A.,Gilbert D.J.,Copeland N.G.,Wong T.W.
Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.
Oncogene
9
211-219
1994
283431
Sakuma S.,Tada M.,Saya H.,Sawamura Y.,Shinohe Y.,Abe H.
Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.
FEBS Lett.
398
165-169
1996
283432
Playford M.P.,Butler R.J.,Wang X.C.,Katso R.M.,Cooke I.E.,Ganesan T.S.
The genomic structure of discoidin receptor tyrosine kinase.
Genome Res.
6
620-627
1996
283433
Perez J.L.,Jing S.Q.,Wong T.W.
Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.
Oncogene
12
1469-1477
1996
283434
Jin P.,Zhang J.,Sumariwalla P.F.,Ni I.,Jorgensen B.,Crawford D.,Phillips S.,Feldmann M.,Shepard H.M.,Paleolog E.M.
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Arthritis Res. Ther.
10
0-0
2008
283435
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
283437
Shiina T.,Ota M.,Shimizu S.,Katsuyama Y.,Hashimoto N.,Takasu M.,Anzai T.,Kulski J.K.,Kikkawa E.,Naruse T.,Kimura N.,Yanagiya K.,Watanabe A.,Hosomichi K.,Kohara S.,Iwamoto C.,Umehara Y.,Meyer A.,Wanner V.,Sano K.,Macquin C.,Ikeo K.,Tokunaga K.,Gojobori T.,Inoko H.,Bahram S.
Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
Genetics
173
1555-1570
2006
283438
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
283440
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
283441
Fu H.L.,Valiathan R.R.,Payne L.,Kumarasiri M.,Mahasenan K.V.,Mobashery S.,Huang P.,Fridman R.
Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).
J. Biol. Chem.
289
9275-9287
2014
283442
Alves F.,Vogel W.,Mossie K.,Millauer B.,Hoefler H.,Ullrich A.
Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer.
Oncogene
10
609-618
1995
283443
Weiner T.M.,Liu E.T.,Craven R.J.,Cance W.G.
Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.
Ann. Surg. Oncol.
1
18-27
1994
283444
Lee S.-T.,Strunk K.M.,Spritz R.A.
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
Oncogene
8
3403-3410
1993
283445
Vogel W.,Gish G.D.,Alves F.,Pawson T.
The discoidin domain receptor tyrosine kinases are activated by collagen.
Mol. Cell
1
13-23
1997
283446
Hou G.,Vogel W.F.,Bendeck M.P.
Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.
Circ. Res.
90
1147-1149
2002
283447
Koo D.H.,McFadden C.,Huang Y.,Abdulhussein R.,Friese-Hamim M.,Vogel W.F.
Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.
FEBS Lett.
580
15-22
2006
283448
Ram R.,Lorente G.,Nikolich K.,Urfer R.,Foehr E.,Nagavarapu U.
Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.
J. Neurooncol.
76
239-248
2006
283449
Hilton H.N.,Stanford P.M.,Harris J.,Oakes S.R.,Kaplan W.,Daly R.J.,Ormandy C.J.
KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.
Biochim. Biophys. Acta
1783
383-393
2008
283450
Huang Y.,Arora P.,McCulloch C.A.,Vogel W.F.
The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA.
J. Cell Sci.
122
1637-1646
2009
283451
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
283452
Eswaramoorthy R.,Wang C.K.,Chen W.C.,Tang M.J.,Ho M.L.,Hwang C.C.,Wang H.M.,Wang C.Z.
DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.
J. Cell. Physiol.
224
387-397
2010
283453
Lu K.K.,Trcka D.,Bendeck M.P.
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.
Cardiovasc. Pathol.
20
71-76
2011
283454
Roberts M.E.,Magowan L.,Hall I.P.,Johnson S.R.
Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production.
Eur. Respir. J.
37
1482-1493
2011
283455
Xu H.,Raynal N.,Stathopoulos S.,Myllyharju J.,Farndale R.W.,Leitinger B.
Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.
Matrix Biol.
30
16-26
2011
283456
Carafoli F.,Mayer M.C.,Shiraishi K.,Pecheva M.A.,Chan L.Y.,Nan R.,Leitinger B.,Hohenester E.
Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.
Structure
20
688-697
2012
283457
Kim H.G.,Tan L.,Weisberg E.L.,Liu F.,Canning P.,Choi H.G.,Ezell S.A.,Wu H.,Zhao Z.,Wang J.,Mandinova A.,Griffin J.D.,Bullock A.N.,Liu Q.,Lee S.W.,Gray N.S.
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
ACS Chem. Biol.
8
2145-2150
2013
283458
Canning P.,Tan L.,Chu K.,Lee S.W.,Gray N.S.,Bullock A.N.
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
J. Mol. Biol.
426
2457-2470
2014
283459
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
