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Sequence of EP300_MOUSE

EC Number:2.3.1.48

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
histone acetyltransferase
B2RWS6
Mus musculus
2412
263305
Reaction
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine

General information:

Sequence
show sequence in fasta format
   0 MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD
  60 ISQLQTSLGI VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQAMASQAQQ NSPGLSLINS
 120 MVKSPMAQTG LTSPNMGIGS SGPNQGPTQS PAGMMNSPVN QPAMGMNTGM NAGMNPGMLA
 180 AGNGQGIMPN QVMNGSIGAG RGRPNMQYPN AGMGNAGSLL TEPLQQGSPQ MGGQPGLRGP
 240 QPLKMGMMNN PSPYGSPYTQ NSGQQIGASG LGLQIQTKTV LPNNLSPFAM DKKAVPGGGM
 300 PSMGQQPTPS VQQPGLVTPV AAGMGSGAHT ADPEKRKLIQ QQLVLLLHAH KCQRREQANG
 360 EVRQCNLPHC RTMKNVLNHM THCQSGKSCQ VAHCASSRQI ISHWKNCTRH DCPVCLPLKN
 420 AGDKRNQQSI LTGAPVGLGN PSSLGVGQQS TPSLSTVSQI DPSSIERAYA ALGLPYQVNQ
 480 IPPQPQVQAK NQQSQPSGQS PQGMRSVNNM SASPMGVNGG VGVQTPNLLS DSMLHSTINS
 540 QNPMMSENAG VASLGPLPTA AQPSSTGIRK QWHEDITQDL RNHLVHKLVQ AIFPTPDPAA
 600 LKDRRMENLV AYARKVEGDM YESANNRAEY YHLLAEKIYK IQKELEEKRR TRLQKQNMLP
 660 NAPGMGPVPM NTGSNMGQQP TGMTTNGPVP DPSMIRGSVP NHMMPRMTPQ PGLNQFGQMN
 720 MPQPPIGPRQ PSPLQHHGQL AQSGSLNPPM GYGPRMQQAS GQNQFLSQTQ FTSQGMNVTN
 780 MPLAPSSGQA PVSQAQMSSS SCPVNSPIMP PGSQGSHIHC PTLPQQAHQN SPSPVPSRTP
 840 TPHHTPPSIG NQPPPATAIP TPVPTPPAIP PGPQPPSLHP SSRQTPTPPT HLPPQVQPSL
 900 PAAPSADQSQ QQPRSQQSTA VSVPTPTAPL LPPQPSTPLS QPAVSIEGQV SNPPSTSSTE
 960 VNSQTIPEKQ PSQEVKMESK MEVDKPEPAD AQPEDTKEAK GEDVKVEPTE MEERGPELKT
1020 DGKEEEEQPS TSATQSSPAP GQSKKKIFKP EELRQALMPT LEALYRQDPE SLPFRQPVDP
1080 QLLGIPDYFD IVKSPMDLST IKRKLDTGQY QEPWQYIDDI WLMFNNAWLY NRKTSRVYKY
1140 CSKLSEVFEQ EIDPVMQSLG YCCGRKLEFS PQTLCCYGKQ LCTIPRDATY YSYQNRYHFC
1200 EKCFNEIQGE SVSLGDDPSQ PQTTINKEQF SKRKNDTLDP ELFVECTECG RKMHQICVLH
1260 HEIIWPSGFV CDGCLKKTAR TRKENKLSAK RLPSTRLGTF LENRVNDFLR RQNHPESGEV
1320 TVRVVHASDK TVEVKPGMKA RFVDSGEMAE SFPYRTKALF AFEEIDGVDL CFFGMHVQEY
1380 GSDCPPPNQR RVYISYLDSV HFFRPKCLRT AVYHEILIGY LEYVKKLGYT TGHIWACPPS
1440 EGDDYIFHCH PPDQKIPKPK RLQEWYKKML DKAVSERIVH DYKDILKQAT EDRLTSAKEL
1500 PYFEGDFWPN VLEESIKELE QEEEERKREE NTSNESTDVT KGDSKNAKKK NNKKTSKNKS
1560 SLSRGNKKKP GMPNVSNDLS QKLYATMEKH KEVFFVIRLI ACPAPNSLPP IVDPDPLIPC
1620 DLMDGRDAFL TLARDKHLEF SSLRRAQWST MCMLVELHTQ SQDRFVYTCN ECKHHVETRW
1680 HCTVCEDYDL CITCYNTKNH DHKMEKLGLG LDDESNNQQA AATQSPGDSR RLSIQRCIQS
1740 LVHACQCRNA NCSLPSCQKM KRVVQHTKGC KRKTNGGCPI CKQLIALCCY HAKHCQENKC
1800 PVPFCLNIKQ KLRQQQLQHR LQQAQMLRRR MASMQRTGVA GQQQGLPSPT PATPTTPTGQ
1860 QPATPQTPQP QPTSQPQPTP PNNMTPYLPR TQTTGPVSQG KAPGQVTPPT PPQTAQAPLP
1920 GPPPAAVEMA MQIQRAAETQ RQMAHVQIFQ RPIQHQMPQM SPMAPMGMNP PPMARGPGGH
1980 LDPGIGPAGM QQQPPWAQGG MPQPQQMQSG MPRPAMMSVA QHGQPLNMAP QPGLGQVGVS
2040 PLKPGTVSQQ ALQNLLRTLR SPSSPLQQQQ VLSILHANPQ LLAAFIKQRA AKYANPNPQP
2100 LPGQPGMTQG QPGLQPPTMP GQQGVHSNPA LQNMNPLQAG VQRAGLPQQQ PQQQLQPPMG
2160 AMSPQAQQMN MNHNTMPSQF RDILRRQMMQ QQGAGPGIGP GMANQFQQPQ GIGYPPQQQQ
2220 QQRMQHHMQQ MQQGNMGQMG QLPQALGAEA GASLQAYQQR LLQQQMGSPA QPNPMSPQQH
2280 MLPNQAQSPH LQGQQIPNSL SNQVRSPQPV PSPRPQSQPP HSSPSPRMQP QPSPHHVSPQ
2340 TSSPHPGLVA AQAANPMEQG HFASPDQNSM LSQLASNPGM ANLHGASATD LGLSSDNADL
2400 NSNLSQSTLD IH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
133046
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
E1000112-E1000112
2009
133047
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
133048
Mutoh H.,Naya F.J.,Tsai M.J.,Leiter A.B.
The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells.
Genes Dev.
12
820-830
1998
133049
Glenn D.J.,Maurer R.A.
MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.
J. Biol. Chem.
274
36159-36167
1999
133050
Yahata T.,de Caestecker M.P.,Lechleider R.J.,Andriole S.,Roberts A.B.,Isselbacher K.J.,Shioda T.
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
J. Biol. Chem.
275
8825-8834
2000
133051
Mehra-Chaudhary R.,Matsui H.,Raghow R.
Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter.
Biochem. J.
353
13-22
2001
133052
Wansa K.D.,Harris J.M.,Yan G.,Ordentlich P.,Muscat G.E.
The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.
J. Biol. Chem.
278
24776-24790
2003
133053
Curtis A.M.,Seo S.B.,Westgate E.J.,Rudic R.D.,Smyth E.M.,Chakravarti D.,FitzGerald G.A.,McNamara P.
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
J. Biol. Chem.
279
7091-7097
2004
133054
Cao D.,Wang Z.,Zhang C.L.,Oh J.,Xing W.,Li S.,Richardson J.A.,Wang D.Z.,Olson E.N.
Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.
Mol. Cell. Biol.
25
364-376
2005
133055
Aikawa Y.,Nguyen L.A.,Isono K.,Takakura N.,Tagata Y.,Schmitz M.L.,Koseki H.,Kitabayashi I.
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
EMBO J.
25
3955-3965
2006
133056
Cesena T.I.,Cui T.X.,Subramanian L.,Fulton C.T.,Iniguez-Lluhi J.A.,Kwok R.P.,Schwartz J.
Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.
Mol. Cell. Endocrinol.
289
94-101
2008
133057
Ohoka N.,Kato S.,Takahashi Y.,Hayashi H.,Sato R.
The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.
Mol. Endocrinol.
23
759-771
2009
133058
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
133059
Pickard A.,Wong P.P.,McCance D.J.
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.
J. Cell Sci.
123
3718-3726
2010
133060
Zhang M.,Zhang J.,Rui J.,Liu X.
p300-mediated acetylation stabilizes the Th-inducing POK factor.
J. Immunol.
185
3960-3969
2010
133061
Wang F.M.,Chen Y.J.,Ouyang H.J.
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
Biochem. J.
433
245-252
2011
133062
Park J.,Chen Y.,Tishkoff D.X.,Peng C.,Tan M.,Dai L.,Xie Z.,Zhang Y.,Zwaans B.M.,Skinner M.E.,Lombard D.B.,Zhao Y.
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Mol. Cell
50
919-930
2013
133063
Ryu D.,Jo Y.S.,Lo Sasso G.,Stein S.,Zhang H.,Perino A.,Lee J.U.,Zeviani M.,Romand R.,Hottiger M.O.,Schoonjans K.,Auwerx J.
A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function.
Cell Metab.
20
856-869
2014
133064
Zhao Y.,Zhang Y.D.,Zhang Y.Y.,Qian S.W.,Zhang Z.C.,Li S.F.,Guo L.,Liu Y.,Wen B.,Lei Q.Y.,Tang Q.Q.,Li X.
p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation.
Mol. Cell. Biol.
34
315-324
2014
133065
Goudarzi A.,Zhang D.,Huang H.,Barral S.,Kwon O.K.,Qi S.,Tang Z.,Buchou T.,Vitte A.L.,He T.,Cheng Z.,Montellier E.,Gaucher J.,Curtet S.,Debernardi A.,Charbonnier G.,Puthier D.,Petosa C.,Panne D.,Rousseaux S.,Roeder R.G.,Zhao Y.,Khochbin S.
Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.
Mol. Cell
62
169-180
2016
133066
Noritsugu K.,Ito A.,Nakao Y.,Yoshida M.
Identification of zinc finger transcription factor EGR2 as a novel acetylated protein.
Biochem. Biophys. Res. Commun.
489
455-459
2017
133067
Lai Y.,Li J.,Li X.,Zou C.
Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.
J. Cell Sci.
130
3578-3587
2017