Sequence of CBPC5_RAT

This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.

show sequence in fasta format Highlight sequence feature Active site (Proton donor/acceptor) Binding site Compositional bias (Basic and acidic residues) Compositional bias (Low complexity) Compositional bias (Polar residues) Domain (Peptidase M14) Region (Disordered)

in fasta format

in fasta format

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