Sequence of CDK5_HUMAN
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH
60 KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR
120 NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS
180 TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP
240 MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
274699
Meyerson M.,Enders G.H.,Wu C.-L.,Su L.-K.,Gorka C.,Nelson C.,Harlow E.,Tsai L.-H.
A family of human cdc2-related protein kinases.
EMBO J.
11
2909-2917
1992
274701
Li Q.,Liu X.,Zhang M.,Ye G.,Qiao Q.,Ling Y.,Wu Y.,Zhang Y.,Yu L.
Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.
Mol. Biol. Rep.
37
2415-2421
2010
274704
Hillier L.W.,Fulton R.S.,Fulton L.A.,Graves T.A.,Pepin K.H.,Wagner-McPherson C.,Layman D.,Maas J.,Jaeger S.,Walker R.,Wylie K.,Sekhon M.,Becker M.C.,O'Laughlin M.D.,Schaller M.E.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Cordes M.,Du H.,Sun H.,Edwards J.,Bradshaw-Cordum H.,Ali J.,Andrews S.,Isak A.,Vanbrunt A.,Nguyen C.,Du F.,Lamar B.,Courtney L.,Kalicki J.,Ozersky P.,Bielicki L.,Scott K.,Holmes A.,Harkins R.,Harris A.,Strong C.M.,Hou S.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Leonard S.,Rohlfing T.,Rock S.M.,Tin-Wollam A.-M.,Abbott A.,Minx P.,Maupin R.,Strowmatt C.,Latreille P.,Miller N.,Johnson D.,Murray J.,Woessner J.P.,Wendl M.C.,Yang S.-P.,Schultz B.R.,Wallis J.W.,Spieth J.,Bieri T.A.,Nelson J.O.,Berkowicz N.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Bedell J.A.,Mardis E.R.,Clifton S.W.,Chissoe S.L.,Marra M.A.,Raymond C.,Haugen E.,Gillett W.,Zhou Y.,James R.,Phelps K.,Iadanoto S.,Bubb K.,Simms E.,Levy R.,Clendenning J.,Kaul R.,Kent W.J.,Furey T.S.,Baertsch R.A.,Brent M.R.,Keibler E.,Flicek P.,Bork P.,Suyama M.,Bailey J.A.,Portnoy M.E.,Torrents D.,Chinwalla A.T.,Gish W.R.,Eddy S.R.,McPherson J.D.,Olson M.V.,Eichler E.E.,Green E.D.,Waterston R.H.,Wilson R.K.
The DNA sequence of human chromosome 7.
Nature
424
157-164
2003
274705
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
274706
Meijer L.,Borgne A.,Mulner O.,Chong J.P.J.,Blow J.J.,Inagaki N.,Inagaki M.,Delcros J.-G.,Moulinoux J.-P.
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Eur. J. Biochem.
243
527-536
1997
274707
Paglini G.,Pigino G.,Kunda P.,Morfini G.,Maccioni R.,Quiroga S.,Ferreira A.,Caceres A.
Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.
J. Neurosci.
18
9858-9869
1998
274708
Sharma P.,Sharma M.,Amin N.D.,Albers R.W.,Pant H.C.
Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
96
11156-11160
1999
274709
Kerokoski P.,Suuronen T.,Salminen A.,Soininen H.,Pirttilae T.
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.
Brain Res. Mol. Brain Res.
106
50-56
2002
274710
Honma N.,Asada A.,Takeshita S.,Enomoto M.,Yamakawa E.,Tsutsumi K.,Saito T.,Satoh T.,Itoh H.,Kaziro Y.,Kishimoto T.,Hisanaga S.
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
Biochem. Biophys. Res. Commun.
310
398-404
2003
274711
Gong X.,Tang X.,Wiedmann M.,Wang X.,Peng J.,Zheng D.,Blair L.A.C.,Marshall J.,Mao Z.
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.
Neuron
38
33-46
2003
274712
Zhu Y.-S.,Saito T.,Asada A.,Maekawa S.,Hisanaga S.
Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation.
J. Neurochem.
94
1535-1545
2005
274713
Kamei H.,Saito T.,Ozawa M.,Fujita Y.,Asada A.,Bibb J.A.,Saido T.C.,Sorimachi H.,Hisanaga S.
Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.
J. Biol. Chem.
282
1687-1694
2007
274714
Munoz J.P.,Huichalaf C.H.,Orellana D.,Maccioni R.B.
cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.
J. Cell. Biochem.
100
738-749
2007
274715
Lee J.-H.,Kim H.-S.,Lee S.-J.,Kim K.-T.
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
J. Cell Sci.
120
2259-2271
2007
274716
Miyamoto Y.,Yamauchi J.,Chan J.R.,Okada A.,Tomooka Y.,Hisanaga S.,Tanoue A.
Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.
J. Cell Sci.
120
4355-4366
2007
274717
Anne S.L.,Saudou F.,Humbert S.
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.
J. Neurosci.
27
7318-7328
2007
274718
Sato K.,Zhu Y.-S.,Saito T.,Yotsumoto K.,Asada A.,Hasegawa M.,Hisanaga S.
Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.
J. Neurosci. Res.
85
3071-3078
2007
274719
Fu W.Y.,Chen Y.,Sahin M.,Zhao X.S.,Shi L.,Bikoff J.B.,Lai K.O.,Yung W.H.,Fu A.K.,Greenberg M.E.,Ip N.Y.
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
Nat. Neurosci.
10
67-76
2007
274720
Asada A.,Yamamoto N.,Gohda M.,Saito T.,Hayashi N.,Hisanaga S.
Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.
J. Neurochem.
106
1325-1336
2008
274721
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
274722
Kim D.,Frank C.L.,Dobbin M.M.,Tsunemoto R.K.,Tu W.,Peng P.L.,Guan J.S.,Lee B.H.,Moy L.Y.,Giusti P.,Broodie N.,Mazitschek R.,Delalle I.,Haggarty S.J.,Neve R.L.,Lu Y.,Tsai L.H.
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
Neuron
60
803-817
2008
274723
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
274724
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
274725
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
274726
Liebl J.,Weitensteiner S.B.,Vereb G.,Takacs L.,Fuerst R.,Vollmar A.M.,Zahler S.
Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.
J. Biol. Chem.
285
35932-35943
2010
274727
Lee C.-H.,Wei Y.-W.,Huang Y.-T.,Lin Y.-T.,Lee Y.-C.,Lee K.-H.,Lu P.-J.
CDK5 phosphorylates eNOS at Ser-113 and regulates NO production.
J. Cell. Biochem.
110
112-117
2010
274728
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
274729
Jain P.,Flaherty P.T.,Yi S.,Chopra I.,Bleasdell G.,Lipay J.,Ferandin Y.,Meijer L.,Madura J.D.
Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.
Bioorg. Med. Chem.
19
359-373
2011
274730
Pan Q.,Qiao F.,Gao C.,Norman B.,Optican L.,Zelenka P.S.
Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).
Cell. Mol. Life Sci.
68
3425-3436
2011
274731
Lee K.Y.,Liu L.,Jin Y.,Fu S.B.,Rosales J.L.
Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.
J. Cell. Physiol.
227
739-750
2012
274732
Sun K.H.,Chang K.H.,Clawson S.,Ghosh S.,Mirzaei H.,Regnier F.,Shah K.
Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity.
J. Neurochem.
118
902-914
2011
274733
Gallazzini M.,Heussler G.E.,Kunin M.,Izumi Y.,Burg M.B.,Ferraris J.D.
High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
Mol. Biol. Cell
22
703-714
2011
274734
Wong A.S.,Lee R.H.,Cheung A.Y.,Yeung P.K.,Chung S.K.,Cheung Z.H.,Ip N.Y.
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Nat. Cell Biol.
13
568-579
2011
274735
Arif A.,Jia J.,Moodt R.A.,DiCorleto P.E.,Fox P.L.
Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.
Proc. Natl. Acad. Sci. U.S.A.
108
1415-1420
2011
274737
Malumbres M.,Barbacid M.
Cell cycle, CDKs and cancer: a changing paradigm.
Nat. Rev. Cancer
9
153-166
2009
274738
Jessberger S.,Gage F.H.,Eisch A.J.,Lagace D.C.
Making a neuron: Cdk5 in embryonic and adult neurogenesis.
Trends Neurosci.
32
575-582
2009
274739
Lalioti V.,Pulido D.,Sandoval I.V.
Cdk5, the multifunctional surveyor.
Cell Cycle
9
284-311
2010
274740
Hisanaga S.,Endo R.
Regulation and role of cyclin-dependent kinase activity in neuronal survival and death.
J. Neurochem.
115
1309-1321
2010
274741
Zhang J.,Herrup K.
Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons.
Cell Cycle
10
1208-1214
2011
274742
Zhu J.,Li W.,Mao Z.
Cdk5: Mediator of neuronal development, death and the response to DNA damage.
Mech. Ageing Dev.
132
389-394
2011
274743
Lopes J.P.,Agostinho P.
Cdk5: multitasking between physiological and pathological conditions.
Prog. Neurobiol.
94
49-63
2011
274744
Kwak Y.,Jeong J.,Lee S.,Park Y.U.,Lee S.A.,Han D.H.,Kim J.H.,Ohshima T.,Mikoshiba K.,Suh Y.H.,Cho S.,Park S.K.
Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.
J. Biol. Chem.
288
36878-36889
2013
274745
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
274746
Magen D.,Ofir A.,Berger L.,Goldsher D.,Eran A.,Katib N.,Nijem Y.,Vlodavsky E.,Tzur S.,Zur S.,Behar D.M.,Fellig Y.,Mandel H.
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5.
Hum. Genet.
134
305-314
2015
274747
Tarricone C.,Dhavan R.,Peng J.,Areces L.B.,Tsai L.-H.,Musacchio A.
Structure and regulation of the CDK5-p25(nck5a) complex.
Mol. Cell
8
657-669
2001
274748
Ahn J.S.,Radhakrishnan M.L.,Mapelli M.,Choi S.,Tidor B.,Cuny G.D.,Musacchio A.,Yeh L.A.,Kosik K.S.
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
Chem. Biol.
12
811-823
2005
274749
Mapelli M.,Massimiliano L.,Crovace C.,Seeliger M.A.,Tsai L.H.,Meijer L.,Musacchio A.
Mechanism of CDK5/p25 binding by CDK inhibitors.
J. Med. Chem.
48
671-679
2005
274750
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
